format-version: 1.2 data-version: releases/2020-01-01 subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_drosophila "Drosophila GO slim" subsetdef: goslim_flybase_ribbon "FlyBase Drosophila GO ribbon slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_yeast "Yeast GO slim" synonymtypedef: syngo_official_label "label approved by the SynGO project" synonymtypedef: systematic_synonym "Systematic synonym" EXACT default-namespace: gene_ontology remark: cvs version: $Revision: 38972$ remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 18 Logical Axioms: 0] ontology: go property_value: http://purl.org/dc/terms/license http://creativecommons.org/licenses/by/4.0/ [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0000005 name: obsolete ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. synonym: "ribosomal chaperone activity" EXACT [] is_obsolete: true consider: GO:0042254 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0000006 name: high-affinity zinc transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT [] synonym: "high-affinity zinc uptake transmembrane transporter activity" RELATED [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000008 name: obsolete thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. synonym: "thioredoxin" EXACT [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248] synonym: "1,6-alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.232 xref: Reactome:R-HSA-449718 "Addition of a third mannose to the N-glycan precursor by ALG2" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [PMID:9708911] xref: KEGG_REACTION:R05612 xref: RHEA:20836 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] synonym: "single-stranded DNA specific endodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific endodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics synonym: "enolase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [PMID:12023280] synonym: "lactase-phlorizin hydrolase activity" BROAD [] synonym: "lactose galactohydrolase activity" EXACT [] xref: EC:3.2.1.108 xref: MetaCyc:LACTASE-RXN xref: Reactome:R-HSA-189062 "lactose + H2O => D-glucose + D-galactose" xref: Reactome:R-HSA-5658001 "Defective LCT does not hydrolyze Lac" xref: RHEA:10076 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006310 ! DNA recombination relationship: regulates GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006312 ! mitotic recombination relationship: regulates GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: obsolete negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. synonym: "negative regulation of recombination within rDNA repeats" EXACT [] is_obsolete: true consider: GO:0045950 [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051231 ! spindle elongation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732] synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] synonym: "malt sugar biosynthesis" EXACT [] synonym: "malt sugar biosynthetic process" EXACT [] synonym: "maltose anabolism" EXACT [] synonym: "maltose biosynthesis" EXACT [] synonym: "maltose formation" EXACT [] synonym: "maltose synthesis" EXACT [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] synonym: "malt sugar catabolic process" EXACT [] synonym: "malt sugar catabolism" EXACT [] synonym: "maltose breakdown" EXACT [] synonym: "maltose degradation" EXACT [] synonym: "maltose hydrolysis" NARROW [] xref: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541] xref: Reactome:R-HSA-446187 "ALG11 transfers the fourth and fifth Man to the N-glycan precursor" xref: Reactome:R-HSA-446215 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1" xref: Reactome:R-HSA-446216 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1" xref: Reactome:R-HSA-4551297 "Defective ALG11 does not transfer Man to the N-glycan precursor" xref: Reactome:R-HSA-4720478 "Defective ALG9 does not add the seventh mannose to the N-glycan precursor" xref: Reactome:R-HSA-9035514 "Defective ALG9 does not add the last mannose to the N-glycan precursor" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000028 name: ribosomal small subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm] xref: Reactome:R-HSA-162797 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" xref: Reactome:R-HSA-162830 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate" xref: Reactome:R-HSA-446198 "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1" xref: Reactome:R-HSA-4720497 "Defective ALG12 does not add mannose to the N-glycan precursor" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups relationship: part_of GO:0097502 ! mannosylation [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai] synonym: "cell wall mannoprotein anabolism" EXACT [] synonym: "cell wall mannoprotein biosynthesis" EXACT [] synonym: "cell wall mannoprotein formation" EXACT [] synonym: "cell wall mannoprotein synthesis" EXACT [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541] xref: Reactome:R-HSA-446188 "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1" xref: Reactome:R-HSA-446208 "Addition of a second mannose to the N-glycan precursor by ALG2" xref: Reactome:R-HSA-4549368 "Defective ALG2 does not transfer a second Man to N-glycan precursor" xref: Reactome:R-HSA-4720473 "Defective ALG3 does not add mannose to the N-glycan precursor" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: MetaCyc:ADENINE-DEAMINASE-RXN xref: RHEA:23688 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732] synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function def: "Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis." [GOC:jl, GOC:vw] synonym: "ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process" EXACT [] is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding is_a: GO:0140104 ! molecular carrier activity intersection_of: GO:0044620 ! ACP phosphopantetheine attachment site binding intersection_of: part_of GO:0006633 ! fatty acid biosynthetic process relationship: part_of GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0000038 name: very long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22." [GOC:hjd] synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf] synonym: "very-long-chain fatty acid metabolic process" EXACT [] synonym: "very-long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: obsolete plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. synonym: "plasma membrane long-chain fatty acid transporter" EXACT [] is_obsolete: true consider: GO:0005324 consider: GO:0005886 [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000044 name: obsolete ascorbate stabilization namespace: biological_process def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "ascorbate stabilization" EXACT [] synonym: "vitamin C stabilization" EXACT [] is_obsolete: true [Term] id: GO:0000045 name: autophagosome assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0070925 ! organelle assembly is_a: GO:1905037 ! autophagosome organization relationship: has_part GO:0019778 ! Atg12 activating enzyme activity relationship: has_part GO:0019786 ! Atg8-specific protease activity relationship: has_part GO:0061651 ! Atg12 conjugating enzyme activity relationship: has_part GO:0061660 ! Atg12 ligase activity [Term] id: GO:0000047 name: obsolete Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "Rieske iron-sulfur protein" EXACT [] synonym: "Rieske iron-sulphur protein" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups relationship: part_of GO:0006412 ! translation [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function alt_id: GO:0000946 def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] synonym: "base pairing with tRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732] synonym: "ornithine cycle" EXACT [] synonym: "urea biosynthesis" EXACT [] synonym: "urea biosynthetic process" EXACT [] xref: MIPS_funcat:01.01.05 xref: MIPS_funcat:01.01.05.03 xref: Wikipedia:Urea_cycle is_a: GO:0019627 ! urea metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0000051 name: obsolete urea cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "urea cycle intermediate metabolic process" EXACT [] synonym: "urea cycle intermediate metabolism" EXACT [] is_obsolete: true [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732] synonym: "argininosuccinate metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0000054 name: ribosomal subunit export from nucleus namespace: biological_process def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] subset: goslim_yeast synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] is_a: GO:0033750 ! ribosome localization is_a: GO:0051656 ! establishment of organelle localization is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal large subunit export from cell nucleus" EXACT [] synonym: "ribosomal large subunit export out of nucleus" EXACT [] synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal large subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal small subunit export from cell nucleus" EXACT [] synonym: "ribosomal small subunit export out of nucleus" EXACT [] synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal small subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000059 name: obsolete protein import into nucleus, docking namespace: biological_process def: "OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] comment: This term was made obsolete because the transient assembly is better captured as a protein-protein association, if at all. synonym: "protein docking during protein import into nucleus" EXACT [] synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein docking during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] synonym: "protein-nucleus import, docking" EXACT [] is_obsolete: true [Term] id: GO:0000060 name: obsolete protein import into nucleus, translocation namespace: biological_process def: "OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "protein import into cell nucleus, translocation" EXACT [] synonym: "protein translocation during protein import into nucleus" EXACT [] synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein translocation during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] synonym: "protein-nucleus import, translocation" EXACT [] is_obsolete: true [Term] id: GO:0000061 name: obsolete protein import into nucleus, substrate release namespace: biological_process def: "OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "protein import into cell nucleus, substrate release" EXACT [] synonym: "protein substrate release during protein import into nucleus" EXACT [] synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein substrate release during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] synonym: "protein-nucleus import, substrate release" EXACT [] is_obsolete: true [Term] id: GO:0000062 name: fatty-acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding is_a: GO:1901567 ! fatty acid derivative binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0000064 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: Reactome:R-HSA-70634 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:1903352 ! L-ornithine transmembrane transport [Term] id: GO:0000067 name: obsolete DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. synonym: "DNA replication and chromosome cycle" EXACT [] is_obsolete: true consider: GO:0006260 consider: GO:0007059 consider: GO:0051276 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0000072 name: obsolete M phase specific microtubule process namespace: biological_process def: "OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] comment: This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary. synonym: "M phase specific microtubule process" EXACT [] synonym: "M-phase specific microtubule process" EXACT [] is_obsolete: true consider: GO:0007017 [Term] id: GO:0000073 name: initial mitotic spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB." [GOC:sgd_curators, GOC:vw] is_a: GO:0110100 ! spindle pole body separation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: part_of GO:1905047 ! mitotic spindle pole body organization [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process alt_id: GO:0031576 alt_id: GO:0071779 def: "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. subset: gocheck_do_not_manually_annotate synonym: "G1/S checkpoint" NARROW [] synonym: "G1/S transition checkpoint" NARROW [] synonym: "G2/M checkpoint" NARROW [] synonym: "G2/M transition checkpoint" NARROW [] xref: MIPS_funcat:10.03.01.03 xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0009987 ! cellular process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000078 name: obsolete cytokinesis after mitosis checkpoint namespace: biological_process def: "OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle] comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw] synonym: "cell shape checkpoint" EXACT [] is_obsolete: true consider: GO:0044878 consider: GO:0044879 [Term] id: GO:0000079 name: regulation of cyclin-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] synonym: "regulation of CDK activity" EXACT [] synonym: "regulation of cyclin-dependent protein kinase activity" BROAD [] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity relationship: regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0000080 name: mitotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.01 is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] xref: MIPS_funcat:10.03.01.01.03 is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044843 ! cell cycle G1/S phase transition intersection_of: GO:0044843 ! cell cycle G1/S phase transition intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000083 name: regulation of transcription involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: mitotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of mitotic cell cycle" EXACT [] synonym: "S-phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.05 is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000085 name: mitotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.07 is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] synonym: "mitotic G2/M transition" EXACT [] xref: MIPS_funcat:10.03.01.01.09 is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044839 ! cell cycle G2/M phase transition intersection_of: GO:0044839 ! cell cycle G2/M phase transition intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000087 name: mitotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of mitotic cell cycle" EXACT [] synonym: "M-phase of mitotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000094 name: obsolete septin assembly and septum formation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. synonym: "septin assembly and septum formation" EXACT [] is_obsolete: true consider: GO:0000917 consider: GO:0000918 consider: GO:0000921 [Term] id: GO:0000095 name: S-adenosyl-L-methionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015177 def: "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] synonym: "SAM transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy" is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1901962 ! S-adenosyl-L-methionine transmembrane transport [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid breakdown" EXACT [] synonym: "sulfur amino acid catabolism" EXACT [] synonym: "sulfur amino acid degradation" EXACT [] synonym: "sulphur amino acid catabolic process" EXACT [] synonym: "sulphur amino acid catabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000100 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015178 def: "Enables the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015806 ! S-methylmethionine transport [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000102 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015191 ! L-methionine transmembrane transporter activity is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process alt_id: GO:0019378 def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] synonym: "sulphate assimilation" EXACT [] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] xref: MIPS_funcat:01.02.01.11 is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [GOC:kd] synonym: "fumarate dehydrogenase activity" EXACT [] synonym: "fumarate reductase activity" EXACT [] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [] synonym: "succinate:acceptor oxidoreductase activity" EXACT [] synonym: "succinic acid dehydrogenase activity" EXACT [] synonym: "succinic dehydrogenase activity" BROAD [] synonym: "succinodehydrogenase activity" EXACT [] synonym: "succinyl dehydrogenase activity" EXACT [] xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: RHEA:16357 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY xref: MIPS_funcat:01.01.09.07.01 is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN] synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2 xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: obsolete repairosome namespace: cellular_component def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators. synonym: "repairosome" EXACT [] is_obsolete: true replaced_by: GO:0000109 [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir synonym: "UvrB-UvrC complex" NARROW [PMID:12145219] synonym: "UvrBC complex" NARROW [GOC:bhm, PMID:12145219] is_a: GO:1990391 ! DNA repair complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex relationship: has_part GO:0000439 ! transcription factor TFIIH core complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: obsolete regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] synonym: "regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0000083 [Term] id: GO:0000115 name: obsolete regulation of transcription involved in S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in S phase of mitotic cell cycle" EXACT [] synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0000116 name: obsolete regulation of transcription involved in G2-phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in G2-phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0000117 [Term] id: GO:0000117 name: regulation of transcription involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0044798 ! nuclear transcription factor complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN xref: RHEA:11476 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0000122 name: negative regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] is_a: GO:0031248 ! protein acetyltransferase complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex is_a: GO:1905368 ! peptidase complex relationship: has_part GO:0071819 ! DUBm complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "PCAF histone acetylase-associated complex" EXACT [] synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:21114594, PMID:8740415] comment: The word floc derives from the Latin word floccus, which means a tuft of wool. subset: goslim_pir xref: Wikipedia:Flocculation is_a: GO:0098630 ! aggregation of unicellular organisms [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "mitotic spindle orientation" EXACT [] synonym: "orienting of mitotic spindle" EXACT [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation intersection_of: GO:0051294 ! establishment of spindle orientation intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005938 ! cell cortex relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0000137 ! Golgi cis cisterna relationship: part_of GO:0030173 ! integral component of Golgi membrane [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] synonym: "late Golgi" RELATED [GOC:mah] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: Reactome:R-HSA-75883 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+" xref: RHEA:17341 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] synonym: "neck ring" EXACT [] is_a: GO:0110085 ! mitotic actomyosin contractile ring intersection_of: GO:0005826 ! actomyosin contractile ring intersection_of: part_of GO:0005935 ! cellular bud neck relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152] synonym: "exocyst complex" EXACT [] synonym: "Sec6/8 complex" EXACT [] xref: Wikipedia:Exocyst is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: Reactome:R-HSA-2316352 "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane" xref: Reactome:R-HSA-432237 "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane" xref: Reactome:R-HSA-9023171 "Insulin secretory granule translocates across the cortical actin network" is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0044396 ! actin cortical patch organization [Term] id: GO:0000148 name: 1,3-beta-D-glucan synthase complex namespace: cellular_component def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34] synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb] synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1990234 ! transferase complex [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] subset: goslim_chembl synonym: "SNAP receptor binding" EXACT [] xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming" xref: Reactome:R-HSA-210430 "release of L-Glutamate at the synapse" xref: Reactome:R-HSA-265166 "Exocytosis of Insulin" xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming" xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse" xref: Reactome:R-HSA-374899 "Release of noradrenaline at the synapse" xref: Reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming" xref: Reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport" xref: Reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport" xref: Reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport" xref: Reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming" xref: Reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle" xref: Reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle" xref: Reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming" xref: Reactome:R-HSA-888589 "Release of GABA at the synapse" xref: Reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane" xref: Reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming" is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: goslim_metagenomics synonym: "strand transferase" NARROW [] xref: Reactome:R-HSA-912458 "Formation of meiotic heteroduplex" is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] subset: goslim_pir is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000154 name: rRNA modification namespace: biological_process alt_id: GO:0016548 def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "rRNA editing" NARROW [GOC:hjd] xref: MIPS_funcat:11.06.01 is_a: GO:0006364 ! rRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0000155 name: phosphorelay sensor kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] synonym: "two-component sensor activity" NARROW [] synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity" NARROW [] xref: EC:2.7.3 is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0140299 ! small molecule sensor activity relationship: part_of GO:0000160 ! phosphorelay signal transduction system relationship: part_of GO:0023014 ! signal transduction by protein phosphorylation [Term] id: GO:0000156 name: phosphorelay response regulator activity namespace: molecular_function def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] comment: Added is_a molecular transducer activity see https://github.com/geneontology/go-ontology/issues/15611 synonym: "two-component response regulator activity" NARROW [] is_a: GO:0060089 ! molecular transducer activity relationship: part_of GO:0000160 ! phosphorelay signal transduction system [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] synonym: "protein phosphatase 2 complex" RELATED [GOC:dph, GOC:rl] is_a: GO:0008287 ! protein serine/threonine phosphatase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000160 name: phosphorelay signal transduction system namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: goslim_metagenomics synonym: "histidyl-aspartyl phosphorelay" EXACT [] synonym: "phosphorelay signal transduction system" NARROW [] xref: MIPS_funcat:30.01.05.07 xref: MIPS_funcat:30.05.01.10 is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0000161 name: osmosensory signaling MAPK cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K." [PMID:17604854, PMID:9561267] synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736] synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736] synonym: "Hog1/Sty1 stress-activated MAPK cascade" NARROW [] synonym: "MAPK cascade involved in osmosensory signaling pathway" EXACT [] synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling] synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] is_a: GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process alt_id: GO:0009096 def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY] synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] synonym: "tryptophan anabolism" EXACT [] synonym: "tryptophan biosynthesis" EXACT [] synonym: "tryptophan formation" EXACT [] synonym: "tryptophan synthesis" EXACT [] xref: MetaCyc:TRPSYN-PWY xref: MIPS_funcat:01.01.09.06.01 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] is_a: GO:0008287 ! protein serine/threonine phosphatase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000165 name: MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. synonym: "ERK/MAPK cascade" NARROW [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK signal transduction" EXACT [GOC:signaling] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade" EXACT [] synonym: "MAPKKK cascade during sporulation" NARROW [] synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] xref: MIPS_funcat:30.01.05.01.03 xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0023014 ! signal transduction by protein phosphorylation is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant xref: MIPS_funcat:16.19 is_a: GO:0036094 ! small molecule binding is_a: GO:1901265 ! nucleoside phosphate binding [Term] id: GO:0000167 name: activation of MAPKKK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000168 name: activation of MAPKK activity involved in osmosensory signaling pathway namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "activation of Pbs2 kinase" NARROW [] synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000169 name: activation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] synonym: "activation of MAPK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: Reactome:R-HSA-428260 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] synonym: "RNase MRP" EXACT [] xref: Wikipedia:RNase_MRP is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0000173 name: inactivation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT [] synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000174 name: obsolete inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13 xref: Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion" xref: Reactome:R-HSA-6791218 "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA" xref: Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA" xref: Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] synonym: "nuclear exosome (ribonuclease complex)" EXACT [] synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) intersection_of: GO:0000178 ! exosome (RNase complex) intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) intersection_of: GO:0000178 ! exosome (RNase complex) intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir synonym: "exosome (ribonucleasease complex)" EXACT [] synonym: "exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:1905354 ! exoribonuclease complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function alt_id: GO:0043790 def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532] xref: Reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851" xref: Reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: obsolete cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. synonym: "cytosolic large ribosomal subunit" EXACT [] is_obsolete: true consider: GO:0022625 [Term] id: GO:0000181 name: obsolete cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. synonym: "cytosolic small ribosomal subunit" EXACT [] is_obsolete: true consider: GO:0022627 [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] synonym: "rDNA chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase" EXACT [] synonym: "activation of MAP3K activity" EXACT [GOC:bf] synonym: "activation of MAPKKK activity during sporulation" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] synonym: "positive regulation of MAPKKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity relationship: positively_regulates GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267] synonym: "activation of MAP kinase kinase activity" EXACT [] synonym: "activation of MAP/ERK kinase kinase" EXACT [] synonym: "activation of MAP2K activity" EXACT [GOC:bf] synonym: "activation of MAPKK activity during sporulation" NARROW [] synonym: "positive regulation of MAPKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity relationship: positively_regulates GO:0004708 ! MAP kinase kinase activity [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] synonym: "activation of MAP kinase" EXACT [] synonym: "activation of MAPK activity during sporulation" NARROW [] synonym: "MAPK activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] synonym: "inactivation of MAPK during sporulation" NARROW [] synonym: "termination of MAPK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity [Term] id: GO:0000189 name: obsolete MAPK import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "nuclear translocation of MAPK" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000190 name: obsolete MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000191 name: obsolete activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000192 name: obsolete activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000193 name: obsolete activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000194 name: obsolete inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000195 name: obsolete nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000196 name: cell wall integrity MAPK cascade namespace: biological_process def: "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:17604854, PMID:9561267] synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] synonym: "MAPK cascade involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAPK cascade involved in cell wall organization or biogenesis" EXACT [] synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] synonym: "Mpk1 cascade" NARROW [PMID:10523653] synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302] synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882] synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094] synonym: "Slt2 cascade" NARROW [PMID:10523653] is_a: GO:0051403 ! stress-activated MAPK cascade intersection_of: GO:0051403 ! stress-activated MAPK cascade intersection_of: part_of GO:0071554 ! cell wall organization or biogenesis relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKKK activity involved in cell wall biogenesis" RELATED [] synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKK activity involved in cell wall biogenesis" RELATED [] synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000199 name: activation of MAPK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAPK activity involved in cell wall biogenesis" NARROW [] synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "inactivation of MAPK activity involved in cell wall organization or biogenesis" RELATED [] synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000201 name: obsolete MAPK import into nucleus involved in cell wall organization or biogenesis namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis." [PMID:9561267] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah] synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000202 name: obsolete MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000203 name: obsolete activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000204 name: obsolete activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000205 name: obsolete activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000206 name: obsolete inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000207 name: obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000208 name: obsolete MAPK import into nucleus involved in osmosensory signaling pathway namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah] synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah] synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah] synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: MetaCyc:NADPYROPHOSPHAT-RXN xref: RHEA:11800 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: obsolete protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. synonym: "protein degradation tagging activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0019941 [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process alt_id: GO:0043147 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah] synonym: "meiotic spindle organisation" EXACT [] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "meiotic spindle stabilization" RELATED [] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-intron endoribonuclease activity" EXACT [] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "SEN complex" EXACT [GOC:se, PMID:22391451] synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451] is_a: GO:1902555 ! endoribonuclease complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function alt_id: GO:0008665 def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] subset: goslim_chembl synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phosphotransferase activity" BROAD [] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0000216 name: obsolete M/G1 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "M/G1 transition of mitotic cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.01.13 is_obsolete: true [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000219 name: obsolete vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" EXACT [] is_obsolete: true consider: GO:0016469 [Term] id: GO:0000220 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0000221 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000223 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN xref: Reactome:R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: MetaCyc:3.1.1.69-RXN xref: Reactome:R-HSA-162857 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate" xref: RHEA:11660 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_drosophila subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:42.04.05 is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000230 name: obsolete nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "nuclear mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000794 [Term] id: GO:0000231 name: obsolete cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "cytoplasmic mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000793 [Term] id: GO:0000232 name: obsolete nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "nuclear interphase chromosome" EXACT [] is_obsolete: true consider: GO:0000228 [Term] id: GO:0000233 name: obsolete cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "cytoplasmic interphase chromosome" EXACT [] is_obsolete: true consider: GO:0000229 [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: KEGG_REACTION:R02037 xref: MetaCyc:2.1.1.103-RXN xref: RHEA:20365 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0005818 ! aster relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098763 ! mitotic cell cycle phase [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex relationship: has_part GO:0005685 ! U1 snRNP [Term] id: GO:0000244 name: spliceosomal tri-snRNP complex assembly namespace: biological_process alt_id: GO:0000351 alt_id: GO:0000355 def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] synonym: "assembly of spliceosomal tri-snRNP" EXACT [] synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] synonym: "snRNP recycling" BROAD [] synonym: "spliceosomal tri-snRNP assembly" EXACT [] synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] is_a: GO:0000387 ! spliceosomal snRNP assembly [Term] id: GO:0000245 name: spliceosomal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] synonym: "spliceosome assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18501] synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: KEGG_REACTION:R05641 xref: MetaCyc:1.3.1.71-RXN xref: RHEA:18501 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: Reactome:R-HSA-195664 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol" xref: Reactome:R-HSA-6807053 "SC5D desaturates LTHSOL to 7-dehydroCHOL" is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14621] synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: KEGG_REACTION:R03199 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: Reactome:R-HSA-191366 "Squalene 2,3-epoxide cyclizes, forming lanosterol" xref: RHEA:14621 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1 xref: Reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one" xref: Reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function alt_id: GO:0050576 def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3-keto-steroid reductase activity" EXACT [] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: MetaCyc:1.1.1.270-RXN xref: MetaCyc:RXN3O-4110 xref: MetaCyc:RXN66-19 xref: MetaCyc:RXN66-24 xref: MetaCyc:RXN66-314 xref: MetaCyc:RXN66-319 xref: Reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)" xref: Reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol" xref: RHEA:18409 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.18.9, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.18.9] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.18.9] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.18.9 xref: MetaCyc:1.14.13.72-RXN xref: Reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol" xref: Reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol" xref: RHEA:55220 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] synonym: "allantoin metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: KEGG_REACTION:R00540 xref: MetaCyc:3.5.5.1-RXN xref: RHEA:21724 xref: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: obsolete isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "isoleucine/valine:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0005304 consider: GO:0015188 [Term] id: GO:0000259 name: obsolete intracellular nucleoside transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. synonym: "intracellular nucleoside transmembrane transporter activity" EXACT [] is_obsolete: true consider: GO:0005337 consider: GO:0005622 [Term] id: GO:0000260 name: obsolete hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. synonym: "hydrogen-translocating V-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0000261 name: obsolete sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. synonym: "sodium-translocating V-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046962 [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0000229 ! cytoplasmic chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: obsolete heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, alpha-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000264 name: obsolete heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, beta-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000265 name: obsolete heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, gamma-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: obsolete cell fraction namespace: cellular_component def: "OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "cell fraction" EXACT [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transmembrane transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein metabolic process" EXACT [] synonym: "murein metabolism" EXACT [] synonym: "peptidoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] xref: MIPS_funcat:01.05.01.03.02 is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process alt_id: GO:0044244 def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] xref: MIPS_funcat:01.05.01.01.02 is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] synonym: "mitochondrial proton-transporting ATP synthase, peripheral stalk" EXACT [] is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: MIPS_funcat:10.03.01 xref: MIPS_funcat:10.03.01.01 xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] xref: MIPS_funcat:10.03.04 xref: MIPS_funcat:10.03.04.07 is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: mitotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] subset: goslim_pombe synonym: "cytokinesis after mitosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). synonym: "bud site selection/establishment of cell polarity" BROAD [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis [Term] id: GO:0000284 name: obsolete shmoo orientation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. synonym: "shmoo orientation" EXACT [] is_obsolete: true replaced_by: GO:0000753 [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13609] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: KEGG_REACTION:R05802 xref: MetaCyc:2.7.1.150-RXN xref: Reactome:R-HSA-1675910 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane" xref: Reactome:R-HSA-1675921 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane" xref: Reactome:R-HSA-1676134 "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane" xref: Reactome:R-HSA-1676168 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane" xref: RHEA:13609 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1] synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN xref: RHEA:18405 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] synonym: "magnesium binding" EXACT [] xref: MIPS_funcat:16.17.07 is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] synonym: "deadenylation-dependent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000289 name: nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] synonym: "3' to 5' mRNA deadenylation" RELATED [] synonym: "mRNA deadenylation" RELATED [] synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000290 name: deadenylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] synonym: "deadenylylation-dependent decapping" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0110156 ! methylguanosine-cap decapping relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000292 name: RNA fragment catabolic process namespace: biological_process alt_id: GO:0030452 def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] synonym: "group I intron catabolic process" NARROW [] synonym: "RNA fragment breakdown" EXACT [] synonym: "RNA fragment catabolism" EXACT [GOC:mah] synonym: "RNA fragment degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN xref: RHEA:15061 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] synonym: "endonucleolytic mRNA decay" EXACT [] synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "mRNA catabolic process, endonucleolytic" EXACT [] synonym: "mRNA catabolism, endonucleolytic" EXACT [] synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870] xref: Reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity relationship: part_of GO:0051503 ! adenine nucleotide transport [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport is_a: GO:0015893 ! drug transport [Term] id: GO:0000297 name: spermine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity relationship: part_of GO:1903710 ! spermine transmembrane transport [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: obsolete integral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "integral to membrane of membrane fraction" EXACT [] is_obsolete: true consider: GO:0016021 [Term] id: GO:0000300 name: obsolete peripheral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "peripheral to membrane of membrane fraction" EXACT [] is_obsolete: true consider: GO:0019898 [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] xref: MIPS_funcat:20.09.07.29 is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] is_a: GO:0000305 ! response to oxygen radical [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0007584 ! response to nutrient is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000306 name: extrinsic component of vacuolar membrane namespace: cellular_component def: "The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] synonym: "extrinsic to vacuolar membrane" EXACT [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005774 ! vacuolar membrane relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: MetaCyc:2.7.7.1-RXN xref: Reactome:R-HSA-8939959 "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+" xref: RHEA:21360 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity namespace: molecular_function alt_id: GO:0009043 def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt] synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: MetaCyc:XANPRIBOSYLTRAN-RXN xref: RHEA:10800 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0009547 ! plastid ribosome relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0009547 ! plastid ribosome relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] is_a: GO:0015935 ! small ribosomal subunit intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0000313 ! organellar ribosome relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0015934 ! large ribosomal subunit intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0000313 ! organellar ribosome relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphite transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000319 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0000316 ! sulfite transport [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: plant-type vacuole namespace: cellular_component def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole, cell cycle-independent morphology" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole intersection_of: GO:0000323 ! lytic vacuole intersection_of: part_of GO:0000326 ! protein storage vacuole relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000329 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000330 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory." [GOC:jl, PMID:10503189, PMID:23890380] synonym: "central bladder" RELATED [PMID:23890380] synonym: "central vacuole" RELATED [PMID:23890380] xref: Wikipedia:Contractile_vacuole is_a: GO:0005773 ! vacuole is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0062159 ! contractile vacuole complex [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] is_a: GO:0000497 ! DNA template activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [GOC:BHF-UCL, PMID:11884619, PMID:1808260] synonym: "TERT-TERC complex" RELATED [GOC:nc, PMID:19701182] is_a: GO:0005697 ! telomerase holoenzyme complex is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17953] synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: KEGG_REACTION:R02665 xref: MetaCyc:1.13.11.6-RXN xref: Reactome:R-HSA-71218 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde" xref: RHEA:17953 xref: UM-BBD_reactionID:r1027 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] synonym: "down regulation of DNA transposition" EXACT [] synonym: "down-regulation of DNA transposition" EXACT [] synonym: "downregulation of DNA transposition" EXACT [] synonym: "inhibition of DNA transposition" NARROW [] synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0045910 ! negative regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006313 ! transposition, DNA-mediated relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000336 name: positive regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] synonym: "activation of DNA transposition" NARROW [] synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] synonym: "stimulation of DNA transposition" NARROW [] synonym: "up regulation of DNA transposition" EXACT [] synonym: "up-regulation of DNA transposition" EXACT [] synonym: "upregulation of DNA transposition" EXACT [] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0045911 ! positive regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006313 ! transposition, DNA-mediated relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000337 name: regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] synonym: "regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0010528 ! regulation of transposition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006313 ! transposition, DNA-mediated relationship: regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process alt_id: GO:0010388 def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] synonym: "cullin deneddylation" NARROW [] xref: MIPS_funcat:14.07.07 is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] is_a: GO:0000428 ! DNA-directed RNA polymerase complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000348 name: mRNA branch site recognition namespace: biological_process alt_id: GO:0000370 alt_id: GO:0000371 def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw] synonym: "spliceosomal A complex biosynthesis" NARROW [] synonym: "spliceosomal A complex formation" NARROW [] synonym: "spliceosomal B complex biosynthesis" NARROW [] synonym: "spliceosomal B complex formation" NARROW [] synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly [Term] id: GO:0000349 name: generation of catalytic spliceosome for first transesterification step namespace: biological_process alt_id: GO:0000356 alt_id: GO:0000357 def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-2 complex formation" NARROW [] synonym: "spliceosomal C1 complex biosynthesis" NARROW [] synonym: "spliceosomal C1 complex formation" NARROW [] synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000350 name: generation of catalytic spliceosome for second transesterification step namespace: biological_process alt_id: GO:0000358 alt_id: GO:0000359 def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] synonym: "formation of spliceosomal A2-2 complex" NARROW [] synonym: "formation of spliceosomal C1 complex" NARROW [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-3 complex formation" NARROW [] synonym: "spliceosomal C2 complex biosynthesis" NARROW [] synonym: "spliceosomal C2 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000352 name: trans assembly of SL-containing precatalytic spliceosome namespace: biological_process def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000353 name: formation of quadruple SL/U4/U5/U6 snRNP namespace: biological_process def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] comment: Note that this step is analogous to 5' splice site selection in cis-splicing. is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000354 name: cis assembly of pre-catalytic spliceosome namespace: biological_process alt_id: GO:0000360 alt_id: GO:0000361 def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] synonym: "formation of spliceosomal A2-1 complex" NARROW [] synonym: "formation of spliceosomal B1 complex" NARROW [] synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-1 complex formation" NARROW [] synonym: "spliceosomal B1 complex biosynthesis" NARROW [] synonym: "spliceosomal B1 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000362 name: obsolete first U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "first U2-type spliceosomal transesterification activity" EXACT [] synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000363 name: obsolete first U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "first U12-type spliceosomal transesterification activity" EXACT [] synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000364 name: obsolete second U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "second U2-type spliceosomal transesterification activity" EXACT [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000365 name: mRNA trans splicing, via spliceosome namespace: biological_process def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw] synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000366 name: intergenic mRNA trans splicing namespace: biological_process def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw] is_a: GO:0000365 ! mRNA trans splicing, via spliceosome is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000367 name: obsolete second U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "second U12-type spliceosomal transesterification activity" EXACT [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000372 name: Group I intron splicing namespace: biological_process def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). synonym: "mRNA splicing" RELATED [] is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile [Term] id: GO:0000373 name: Group II intron splicing namespace: biological_process def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000374 name: Group III intron splicing namespace: biological_process def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: goslim_pir synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000376 name: RNA splicing, via transesterification reactions with guanosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000378 name: RNA exon ligation namespace: biological_process def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] comment: Note that this is not a part of spliceosomal RNA splicing. is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000379 name: tRNA-type intron splice site recognition and cleavage namespace: biological_process def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] is_a: GO:0006396 ! RNA processing relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000380 name: alternative mRNA splicing, via spliceosome namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000381 name: regulation of alternative mRNA splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000384 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0140098 ! catalytic activity, acting on RNA relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000386 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0140098 ! catalytic activity, acting on RNA relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000387 name: spliceosomal snRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000388 name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) namespace: biological_process alt_id: GO:0000396 alt_id: GO:0000397 def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "spliceosomal A1 complex biosynthesis" NARROW [] synonym: "spliceosomal A1 complex formation" NARROW [] synonym: "spliceosomal B2 complex biosynthesis" NARROW [] synonym: "spliceosomal B2 complex formation" NARROW [] synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000389 name: mRNA 3'-splice site recognition namespace: biological_process alt_id: GO:0000382 alt_id: GO:0000383 def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw] synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection [Term] id: GO:0000390 name: spliceosomal complex disassembly namespace: biological_process alt_id: GO:0000391 alt_id: GO:0000392 def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "spliceosome complex disassembly" EXACT [] synonym: "spliceosome disassembly" BROAD [] synonym: "U12-type spliceosome disassembly" NARROW [] synonym: "U2-type spliceosome disassembly" NARROW [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000393 name: spliceosomal conformational changes to generate catalytic conformation namespace: biological_process def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000395 name: mRNA 5'-splice site recognition namespace: biological_process alt_id: GO:0000368 alt_id: GO:0000369 def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). synonym: "nuclear mRNA 5' splice site recognition" EXACT [] synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw] synonym: "spliceosomal CC complex biosynthesis" NARROW [] synonym: "spliceosomal CC complex formation" NARROW [] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000398 name: mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] xref: MIPS_funcat:11.04.03 is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing [Term] id: GO:0000399 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005935 ! cellular bud neck relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0000400 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000401 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000402 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000403 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "splayed Y-form DNA binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000404 name: heteroduplex DNA loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] synonym: "loop DNA binding" RELATED [GOC:jh] is_a: GO:0000217 ! DNA secondary structure binding is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0000405 name: bubble DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000406 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000407 name: phagophore assembly site namespace: cellular_component def: "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "PAS" EXACT [] synonym: "perivacuolar space" NARROW [] synonym: "pre-autophagosomal structure" NARROW [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000408 name: EKC/KEOPS complex namespace: cellular_component def: "A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934] synonym: "endopeptidase-like kinase chromatin-associated protein complex" EXACT [] synonym: "KEOPS/EKC complex" EXACT [PMID:21183954, PMID:23945934] synonym: "kinase, putative endopeptidase and other proteins of small size protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000409 name: regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] is_a: GO:0006355 ! regulation of transcription, DNA-templated [Term] id: GO:0000410 name: carbon catabolite repression of transcription by galactose namespace: biological_process def: "A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah] synonym: "down regulation of transcription by galactose" EXACT [] synonym: "down-regulation of transcription by galactose" EXACT [] synonym: "downregulation of transcription by galactose" EXACT [] synonym: "inhibition of transcription by galactose" NARROW [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000411 name: positive regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by galactose" NARROW [] synonym: "stimulation of transcription by galactose" NARROW [] synonym: "up regulation of transcription by galactose" EXACT [] synonym: "up-regulation of transcription by galactose" EXACT [] synonym: "upregulation of transcription by galactose" EXACT [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000412 name: histone peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] synonym: "histone proline isomerization" EXACT [] is_a: GO:0000413 ! protein peptidyl-prolyl isomerization is_a: GO:0016570 ! histone modification [Term] id: GO:0000413 name: protein peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] synonym: "protein proline isomerization" EXACT [] is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0000414 name: regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010452 ! histone H3-K36 methylation relationship: regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000415 name: negative regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "down regulation of histone H3-K36 methylation" EXACT [] synonym: "down-regulation of histone H3-K36 methylation" EXACT [] synonym: "downregulation of histone H3-K36 methylation" EXACT [] synonym: "inhibition of histone H3-K36 methylation" NARROW [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031061 ! negative regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010452 ! histone H3-K36 methylation relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000416 name: positive regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "activation of histone H3-K36 methylation" NARROW [] synonym: "stimulation of histone H3-K36 methylation" NARROW [] synonym: "up regulation of histone H3-K36 methylation" EXACT [] synonym: "up-regulation of histone H3-K36 methylation" EXACT [] synonym: "upregulation of histone H3-K36 methylation" EXACT [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031062 ! positive regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010452 ! histone H3-K36 methylation relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000417 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0000418 name: RNA polymerase IV complex namespace: cellular_component alt_id: GO:0000420 def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IV complex" EXACT [] synonym: "DNA-directed RNA polymerase IVa complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000419 name: RNA polymerase V complex namespace: cellular_component alt_id: GO:0080137 def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IVb complex" EXACT [] synonym: "DNA-directed RNA polymerase V complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000421 name: autophagosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete] synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005776 ! autophagosome [Term] id: GO:0000422 name: autophagy of mitochondrion namespace: biological_process def: "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] synonym: "mitochondrion autophagy" EXACT [GOC:autophagy] synonym: "mitophagy" RELATED [] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0006914 ! autophagy is_a: GO:0061726 ! mitochondrion disassembly [Term] id: GO:0000423 name: mitophagy namespace: biological_process def: "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367] comment: Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes. synonym: "macromitophagy" EXACT [] is_a: GO:0000422 ! autophagy of mitochondrion is_a: GO:0061912 ! selective autophagy [Term] id: GO:0000424 name: micromitophagy namespace: biological_process def: "Degradation of a mitochondrion by lysosomal microautophagy." [PMID:15798367, PMID:27003723] comment: Note that this term is not a child of mitophagy because the community genrally uses that latter to refer to the macroautophagy of mitochondria. is_a: GO:0000422 ! autophagy of mitochondrion is_a: GO:0016237 ! lysosomal microautophagy [Term] id: GO:0000425 name: pexophagy namespace: biological_process def: "The selective autophagy process in which a peroxisome is degraded by macroautophagy." [GOC:autophagy, PMID:12914914, PMID:16973210] synonym: "macropexophagy" EXACT [] is_a: GO:0030242 ! autophagy of peroxisome is_a: GO:0061912 ! selective autophagy [Term] id: GO:0000426 name: micropexophagy namespace: biological_process def: "Degradation of a peroxisome by lysosomal microautophagy." [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210] comment: Note that this term is not a child of pexophagy because the community usually uses the latter to refer to the macroautohagy process. is_a: GO:0016237 ! lysosomal microautophagy is_a: GO:0030242 ! autophagy of peroxisome [Term] id: GO:0000427 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] is_a: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0000428 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0000429 name: carbon catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000430 name: regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0000431 name: regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000432 name: positive regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0046016 ! positive regulation of transcription by glucose [Term] id: GO:0000433 name: carbon catabolite repression of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] is_a: GO:0045014 ! carbon catabolite repression of transcription by glucose is_a: GO:0061987 ! negative regulation of transcription from RNA polymerase II promoter by glucose [Term] id: GO:0000434 name: carbon catabolite repression of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] is_a: GO:0000410 ! carbon catabolite repression of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter [Term] id: GO:0000435 name: positive regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] is_a: GO:0000411 ! positive regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter [Term] id: GO:0000436 name: carbon catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000437 name: carbon catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc] synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000438 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component alt_id: GO:0000443 def: "The core TFIIH complex when it is part of the general transcription factor TFIIH." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "SSL2-core TFIIH complex portion of holo TFIIH complex" EXACT [] is_a: GO:0000439 ! transcription factor TFIIH core complex intersection_of: GO:0000439 ! transcription factor TFIIH core complex intersection_of: part_of GO:0005675 ! transcription factor TFIIH holo complex relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex [Term] id: GO:0000439 name: transcription factor TFIIH core complex namespace: cellular_component alt_id: GO:0000441 def: "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] subset: goslim_pir synonym: "core TFIIH complex" EXACT [] synonym: "SSL2-core TFIIH complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0000440 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component alt_id: GO:0000442 def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "SSL2-core TFIIH complex portion of NEF3 complex" EXACT [] is_a: GO:0000439 ! transcription factor TFIIH core complex intersection_of: GO:0000439 ! transcription factor TFIIH core complex intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex [Term] id: GO:0000444 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000445 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] is_a: GO:0000347 ! THO complex intersection_of: GO:0000347 ! THO complex intersection_of: part_of GO:0000346 ! transcription export complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000446 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072] is_a: GO:0000347 ! THO complex is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0000447 name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A2" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000448 name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:0000490 def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "cleavage at C2" RELATED [] synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000449 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000450 name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000451 name: rRNA 2'-O-methylation namespace: biological_process def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0000452 name: snoRNA guided rRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337] synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000453 name: enzyme-directed rRNA 2'-O-methylation namespace: biological_process def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000454 name: snoRNA guided rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000455 name: enzyme-directed rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000456 name: obsolete dimethylation involved in SSU-rRNA maturation namespace: biological_process def: "OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337] comment: The reason for obsoletion is that this term can be captured as a GO-CAM model. is_obsolete: true [Term] id: GO:0000457 name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000458 name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000459 name: exonucleolytic trimming involved in rRNA processing namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic intersection_of: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic intersection_of: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000460 name: maturation of 5.8S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000461 name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at site D" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000462 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:1990041 def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] synonym: "maturation of 18S rRNA" NARROW [] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000463 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000464 name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at A3" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000465 name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000466 name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000467 name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000468 name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] synonym: "processing at B2" NARROW [] is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000469 name: cleavage involved in rRNA processing namespace: biological_process def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis intersection_of: GO:0090501 ! RNA phosphodiester bond hydrolysis intersection_of: part_of GO:0006364 ! rRNA processing relationship: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000470 name: maturation of LSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000471 name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000472 name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A1" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000473 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000474 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000475 name: maturation of 2S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000476 name: maturation of 4.5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000477 name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "processing at C1" NARROW [] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000478 name: endonucleolytic cleavage involved in rRNA processing namespace: biological_process def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic intersection_of: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic intersection_of: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000479 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000480 name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] synonym: "endonucleolytic cleavage at A0" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000482 name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000481 ! maturation of 5S rRNA [Term] id: GO:0000483 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000484 name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000485 name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA [Term] id: GO:0000486 name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000487 name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000488 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000489 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000491 name: small nucleolar ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "snoRNP assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0000492 name: box C/D snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000493 name: box H/ACA snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000494 name: box C/D snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] synonym: "box C/D snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0000497 name: DNA template activity namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. synonym: "base pairing with DNA" RELATED [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000500 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "RNA polymerase I upstream activation factor complex" EXACT [] synonym: "UAF" EXACT [] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The reversible, non-sexual aggregation of cells mediated by the binding of proteins in the cell wall of one cell to carbohydrates in the cell wall of another cell. An example of this process is found in Saccharomyces cerevisiae, in which it is pH- and calcium-dependent." [GOC:mcc, GOC:sgd_curators, GOC:vw, PMID:21114594] is_a: GO:0000128 ! flocculation [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] subset: goslim_pir synonym: "26S proteasome" NARROW [] synonym: "proteasome" EXACT [GOC:cjm] is_a: GO:1905369 ! endopeptidase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000504 name: obsolete proteasome regulatory particle (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. synonym: "26S proteasome" NARROW [] synonym: "proteasome regulatory particle (sensu Bacteria)" EXACT [] is_obsolete: true [Term] id: GO:0000506 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2 is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0000702 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000703 name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0019004 def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: Reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase" xref: Reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase" xref: Reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity [Term] id: GO:0000704 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000705 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] synonym: "achiasmate meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I [Term] id: GO:0000706 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000729 ! DNA double-strand break processing intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000707 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000708 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw] is_a: GO:0042148 ! strand invasion is_a: GO:0061982 ! meiosis I cell cycle process intersection_of: GO:0042148 ! strand invasion intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000709 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000710 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] is_a: GO:0006298 ! mismatch repair is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000711 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000712 name: resolution of meiotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] is_a: GO:0061982 ! meiosis I cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0051307 ! meiotic chromosome separation [Term] id: GO:0000713 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] is_a: GO:0061982 ! meiosis I cell cycle process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0000732 ! strand displacement is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000715 name: nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000716 name: transcription-coupled nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0000717 name: nucleotide-excision repair, DNA duplex unwinding namespace: biological_process def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0032508 ! DNA duplex unwinding intersection_of: GO:0032508 ! DNA duplex unwinding intersection_of: part_of GO:0006289 ! nucleotide-excision repair relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000718 name: nucleotide-excision repair, DNA damage removal namespace: biological_process def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0044349 ! DNA excision relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000719 name: photoreactive repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] synonym: "pyrimidine-dimer repair by photolyase" NARROW [] is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000720 name: pyrimidine dimer repair by nucleotide-excision repair namespace: biological_process def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. is_a: GO:0006289 ! nucleotide-excision repair is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000721 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4] synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN xref: RHEA:24340 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000722 name: telomere maintenance via recombination namespace: biological_process def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] synonym: "telomerase-independent telomere maintenance" RELATED [] is_a: GO:0000723 ! telomere maintenance is_a: GO:0006312 ! mitotic recombination [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] is_a: GO:0006281 ! DNA repair [Term] id: GO:0000727 name: double-strand break repair via break-induced replication namespace: biological_process def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0022414 ! reproductive process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0035312 ! 5'-3' exodeoxyribonuclease activity relationship: part_of GO:0006302 ! double-strand break repair [Term] id: GO:0000730 name: DNA recombinase assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] is_a: GO:0065004 ! protein-DNA complex assembly is_a: GO:0090735 ! DNA repair complex assembly relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0000731 name: DNA synthesis involved in DNA repair namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] synonym: "DNA repair synthesis" BROAD [] synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah] is_a: GO:0071897 ! DNA biosynthetic process intersection_of: GO:0071897 ! DNA biosynthetic process intersection_of: part_of GO:0006281 ! DNA repair relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000733 name: DNA strand renaturation namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032392 ! DNA geometric change [Term] id: GO:0000734 name: gene conversion at mating-type locus, DNA repair synthesis namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0022414 ! reproductive process intersection_of: GO:0000731 ! DNA synthesis involved in DNA repair intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000735 name: removal of nonhomologous ends namespace: biological_process def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000736 name: double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0000735 ! removal of nonhomologous ends intersection_of: GO:0000735 ! removal of nonhomologous ends intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000737 name: DNA catabolic process, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] synonym: "DNA breakdown, endonucleolytic" EXACT [] synonym: "DNA degradation, endonucleolytic" EXACT [] synonym: "endonucleolytic degradation of DNA" EXACT [] synonym: "endonucleolytic DNA catabolism" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: has_part GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000738 name: DNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] synonym: "DNA breakdown, exonucleolytic" EXACT [] synonym: "DNA degradation, exonucleolytic" EXACT [] synonym: "exonucleolytic degradation of DNA" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: has_part GO:0004529 ! exodeoxyribonuclease activity [Term] id: GO:0000739 name: obsolete DNA strand annealing activity namespace: molecular_function def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] comment: This term was made obsolete because it describes a process and not an activity. synonym: "DNA strand annealing activity" EXACT [] is_obsolete: true consider: GO:0000733 consider: GO:0036292 consider: GO:0036310 [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy is_a: GO:0022414 ! reproductive process intersection_of: GO:0000741 ! karyogamy intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440] synonym: "nuclear congression" EXACT [GOC:vw] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0030473 ! nuclear migration along microtubule intersection_of: GO:0007097 ! nuclear migration intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000744 name: karyogamy involved in conjugation with mutual genetic exchange namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena." [GOC:mah, GOC:pg] comment: Changed definition https://github.com/geneontology/go-ontology/issues/16248. synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy intersection_of: GO:0000741 ! karyogamy intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000745 name: nuclear migration involved in conjugation with mutual genetic exchange namespace: biological_process def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration intersection_of: GO:0007097 ! nuclear migration intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Conjugation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction is_a: GO:0140253 ! cell-cell fusion [Term] id: GO:0000748 name: conjugation with mutual genetic exchange namespace: biological_process def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] synonym: "conjugation without cellular fusion" EXACT [] is_a: GO:0000746 ! conjugation [Term] id: GO:0000749 name: response to pheromone triggering conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0071444 ! cellular response to pheromone intersection_of: GO:0019236 ! response to pheromone intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000750 name: pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007330 alt_id: GO:0030454 def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "transduction of mating signal" BROAD [] is_a: GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000751 name: mitotic cell cycle G1 arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "cell cycle arrest in response to pheromone" BROAD [] is_a: GO:0071850 ! mitotic cell cycle arrest relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0098630 ! aggregation of unicellular organisms intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" RELATED [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000756 name: response to pheromone regulating conjugation with mutual genetic exchange namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion." [GOC:clt] synonym: "response to pheromone triggering conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0046999 ! regulation of conjugation is_a: GO:0071444 ! cellular response to pheromone intersection_of: GO:0019236 ! response to pheromone intersection_of: regulates GO:0000748 ! conjugation with mutual genetic exchange relationship: regulates GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000757 name: obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange namespace: biological_process def: "OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] comment: This term was obsoleted because its label and definitions were not clear. It had never been used for annotation. https://github.com/geneontology/go-ontology/issues/15815 synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0000758 name: agglutination involved in conjugation with mutual genetic exchange namespace: biological_process def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] synonym: "sexual flocculation" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0098630 ! aggregation of unicellular organisms intersection_of: GO:0098630 ! aggregation of unicellular organisms intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange [Term] id: GO:0000759 name: cell morphogenesis involved in conjugation with mutual genetic exchange namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000767 ! cell morphogenesis involved in conjugation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000760 name: adaptation to pheromone regulating conjugation with mutual genetic exchange namespace: biological_process def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] is_a: GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000761 name: conjugant formation namespace: biological_process def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] is_a: GO:0000771 ! agglutination involved in conjugation relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000762 name: pheromone-induced unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] is_a: GO:0009291 ! unidirectional conjugation [Term] id: GO:0000763 name: obsolete cell morphogenesis involved in unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cell morphogenesis involved in unidirectional conjugation" EXACT [] is_obsolete: true [Term] id: GO:0000764 name: obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] synonym: "cellular morphogenesis involved in pheromone-induced unidirectional conjugation" EXACT [] is_obsolete: true [Term] id: GO:0000765 name: response to pheromone regulating pheromone-induced unidirectional conjugation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0019236 ! response to pheromone is_a: GO:0046999 ! regulation of conjugation intersection_of: GO:0019236 ! response to pheromone intersection_of: regulates GO:0000762 ! pheromone-induced unidirectional conjugation relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000766 name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0022401 ! negative adaptation of signaling pathway relationship: part_of GO:0000765 ! response to pheromone regulating pheromone-induced unidirectional conjugation [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0000746 ! conjugation relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation intersection_of: has_part GO:0045026 ! plasma membrane fusion [Term] id: GO:0000769 name: syncytium formation by mitosis without cytokinesis namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb] synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah] is_a: GO:0006949 ! syncytium formation intersection_of: GO:0006949 ! syncytium formation intersection_of: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis relationship: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis [Term] id: GO:0000770 name: peptide pheromone export namespace: biological_process alt_id: GO:0007325 def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] synonym: "a-factor export" NARROW [] is_a: GO:0009914 ! hormone transport is_a: GO:0015833 ! peptide transport [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0098610 ! adhesion between unicellular organisms intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000746 ! conjugation relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000772 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0000773 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000774 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] xref: Reactome:R-HSA-5252079 "HSP110s exchange ATP for ADP on HSP70s:ADP" is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component alt_id: GO:0097521 def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. synonym: "centromere" RELATED [] synonym: "centromere complex" EXACT [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] xref: MIPS_funcat:70.10.04 xref: SO:0000577 is_a: GO:0098687 ! chromosomal region [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0099080 ! supramolecular complex relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0000777 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000776 ! kinetochore intersection_of: GO:0000776 ! kinetochore intersection_of: part_of GO:0000793 ! condensed chromosome relationship: part_of GO:0000779 ! condensed chromosome, centromeric region [Term] id: GO:0000778 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000777 ! condensed chromosome kinetochore intersection_of: GO:0000776 ! kinetochore intersection_of: part_of GO:0000794 ! condensed nuclear chromosome relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region [Term] id: GO:0000779 name: condensed chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centric region" EXACT [] synonym: "condensed chromosome, centromere" RELATED [] synonym: "condensed chromosome, pericentric region" RELATED [] is_a: GO:0000775 ! chromosome, centromeric region intersection_of: GO:0000775 ! chromosome, centromeric region intersection_of: part_of GO:0000793 ! condensed chromosome relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000780 name: condensed nuclear chromosome, centromeric region namespace: cellular_component def: "The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centric region" EXACT [] synonym: "condensed nuclear chromosome, centromere" RELATED [] synonym: "condensed nuclear chromosome, pericentric region" RELATED [] is_a: GO:0000779 ! condensed chromosome, centromeric region intersection_of: GO:0000779 ! condensed chromosome, centromeric region intersection_of: part_of GO:0000794 ! condensed nuclear chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] xref: SO:0000624 is_a: GO:0098687 ! chromosomal region [Term] id: GO:0000782 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir is_a: GO:0032993 ! protein-DNA complex relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0000783 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0000782 ! telomere cap complex intersection_of: GO:0000782 ! telomere cap complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0000784 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] is_a: GO:0000781 ! chromosome, telomeric region intersection_of: GO:0000781 ! chromosome, telomeric region intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0000786 name: nucleosome namespace: cellular_component alt_id: GO:0005718 def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: Wikipedia:Nucleosome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044815 ! DNA packaging complex relationship: part_of GO:0000785 ! chromatin [Term] id: GO:0000787 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome intersection_of: GO:0000786 ! nucleosome intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000789 ! cytoplasmic chromatin [Term] id: GO:0000788 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome intersection_of: GO:0000786 ! nucleosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000789 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome intersection_of: GO:0000793 ! condensed chromosome intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000795 name: synaptonemal complex namespace: cellular_component alt_id: GO:0005716 def: "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh] xref: Wikipedia:Synaptonemal_complex is_a: GO:0099086 ! synaptonemal structure [Term] id: GO:0000796 name: condensin complex namespace: cellular_component alt_id: GO:0005676 alt_id: GO:0008620 def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "13S condensin complex" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0044815 ! DNA packaging complex relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000797 name: condensin core heterodimer namespace: cellular_component alt_id: GO:0008621 def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "8S condensin complex" NARROW [] synonym: "Smc2-Smc4 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000796 ! condensin complex [Term] id: GO:0000798 name: nuclear cohesin complex namespace: cellular_component def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0008278 ! cohesin complex intersection_of: GO:0008278 ! cohesin complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000799 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] is_a: GO:0000796 ! condensin complex relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000800 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] comment: In species that have a synaptonemal complex, the lateral elements are part of this complex. S.pombe is an example of a species that lacks a (canonical) synaptonemal complex, but still has lateral elements. synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000801 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000802 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome [Term] id: GO:0000804 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000805 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0582227089, PMID:20622855] xref: Wikipedia:X_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000806 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0582227089, PMID:20622855] xref: Wikipedia:Y_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000807 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0000809 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] is_a: GO:0000808 ! origin recognition complex intersection_of: GO:0000808 ! origin recognition complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000810 name: diacylglycerol diphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [EC:3.1.3.81, GOC:kad, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443] comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two. synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT [] xref: EC:3.1.3.81 xref: MetaCyc:RXN-11277 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0031261 ! DNA replication preinitiation complex relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0000812 name: Swr1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820] synonym: "SWR-C" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0097346 ! INO80-type complex [Term] id: GO:0000813 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000814 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000815 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000817 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000818 name: nuclear MIS12/MIND complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] is_a: GO:0000444 ! MIS12/MIND type complex intersection_of: GO:0000444 ! MIS12/MIND type complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009064 ! glutamine family amino acid metabolic process relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0000821 name: regulation of arginine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] synonym: "regulation of arginine metabolism" EXACT [] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006525 ! arginine metabolic process relationship: regulates GO:0006525 ! arginine metabolic process [Term] id: GO:0000822 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0000823 name: inositol-1,4,5-trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "inositol trisphosphate 6-kinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: EC:2.7.1.151 xref: KEGG_REACTION:R05800 xref: MetaCyc:2.7.1.151-RXN is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0000824 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: Reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000825 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] xref: MetaCyc:RXN-7184 xref: Reactome:R-HSA-1855206 "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000826 name: obsolete inositol pyrophosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326] comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them. synonym: "inositol diphosphate synthase activity" EXACT [] synonym: "inositol pyrophosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0052746 [Term] id: GO:0000827 name: inositol-1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] xref: Reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus" xref: Reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000828 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, GOC:vw, PMID:16429326] xref: Reactome:R-HSA-1855207 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus" xref: Reactome:R-HSA-1855216 "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol" xref: Reactome:R-HSA-1855227 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000829 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326] xref: Reactome:R-HSA-1855157 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus" xref: Reactome:R-HSA-1855182 "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol" xref: Reactome:R-HSA-1855194 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000830 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000831 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000832 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.4.21 xref: KEGG_REACTION:R09087 xref: MetaCyc:2.7.1.152-RXN is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000833 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000834 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000835 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000836 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78)." [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652] synonym: "HRD1 ubiquitin ligase complex" RELATED [GOC:bf] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000837 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000838 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000839 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000900 name: translation repressor activity, mRNA regulatory element binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370] comment: Changed term label as requested in https://github.com/geneontology/go-ontology/issues/15049 synonym: "translation repressor activity, nucleic acid binding" BROAD [] is_a: GO:0030371 ! translation repressor activity is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0000901 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] xref: MIPS_funcat:40.01 is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000903 name: obsolete regulation of cell shape during vegetative growth phase namespace: biological_process alt_id: GO:0090061 def: "OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw] comment: The reason for obsoletion is that biological phases should be captured as extensions. synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw] synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED [] is_obsolete: true [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000905 name: sporocarp development involved in asexual reproduction namespace: biological_process def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] synonym: "conidium development" NARROW [] synonym: "fruiting body formation involved in asexual reproduction" BROAD [] synonym: "haploid fruiting" RELATED [] synonym: "homokaryotic fruiting" RELATED [] synonym: "imperfect stage fruiting body development" NARROW [] synonym: "monokaryotic fruiting" RELATED [] is_a: GO:0030584 ! sporocarp development intersection_of: GO:0030584 ! sporocarp development intersection_of: part_of GO:0019954 ! asexual reproduction relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:2.5.1.78 xref: MetaCyc:LUMAZINESYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000907 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0000908 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15909] synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: KEGG_REACTION:R05320 xref: MetaCyc:RXN0-299 xref: RHEA:15909 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0000909 name: sporocarp development involved in sexual reproduction namespace: biological_process def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] synonym: "ascus development" NARROW [] synonym: "fruiting body development involved in sexual reproduction" BROAD [] synonym: "fruiting body formation involved in sexual reproduction" BROAD [] synonym: "perfect stage fruiting body development" NARROW [] is_a: GO:0030584 ! sporocarp development intersection_of: GO:0030584 ! sporocarp development intersection_of: part_of GO:0019953 ! sexual reproduction relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 alt_id: GO:0033205 def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell cycle cytokinesis" EXACT [] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:10.03.03 xref: Wikipedia:Cytokinesis is_a: GO:0022402 ! cell cycle process relationship: has_part GO:0090148 ! membrane fission relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000911 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] is_a: GO:0000910 ! cytokinesis [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis [Term] id: GO:0000913 name: preprophase band assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] synonym: "preprophase band formation" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000914 name: phragmoplast assembly namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] synonym: "phragmoplast formation" RELATED [goc:dph] is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000915 name: actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT [] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis is_a: GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0000916 name: actomyosin contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] is_a: GO:0036213 ! contractile ring contraction relationship: part_of GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0000917 name: division septum assembly namespace: biological_process alt_id: GO:0071937 alt_id: GO:1902411 def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle] synonym: "division septum assembly involved in cell cycle cytokinesis" NARROW [] synonym: "division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "division septum formation" EXACT [GOC:mah] synonym: "division septum formation involved in cell cycle cytokinesis" NARROW [] synonym: "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "formation of division septum" EXACT [] synonym: "formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "mitotic division septum assembly" NARROW [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "septin assembly and septum formation" RELATED [] synonym: "septin assembly and septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] xref: MIPS_funcat:10.03.03 is_a: GO:0090529 ! cell septum assembly [Term] id: GO:0000918 name: division septum site selection namespace: biological_process def: "The process of marking the site where a division septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "selection of site for division septum formation" EXACT [] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000917 ! division septum assembly [Term] id: GO:0000919 name: cell plate assembly namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] synonym: "cell plate formation" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000920 name: septum digestion after cytokinesis namespace: biological_process alt_id: GO:1902409 alt_id: GO:2000695 def: "The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:vw] comment: This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process. synonym: "cell separation after cytokinesis" RELATED [] synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinetic cell separation" RELATED [] synonym: "daughter cell separation" RELATED [] synonym: "mitotic cytokinetic cell separation" BROAD [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000921 name: septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] is_a: GO:0031106 ! septin ring organization is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0070925 ! organelle assembly [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005819 ! spindle [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center intersection_of: GO:0005815 ! microtubule organizing center intersection_of: part_of GO:0032153 ! cell division site relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0000924 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component alt_id: GO:0000925 alt_id: GO:0000926 def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] is_a: GO:0008274 ! gamma-tubulin ring complex intersection_of: GO:0008274 ! gamma-tubulin ring complex intersection_of: part_of GO:0000242 ! pericentriolar material relationship: part_of GO:0000242 ! pericentriolar material [Term] id: GO:0000927 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0008275 ! gamma-tubulin small complex [Term] id: GO:0000928 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075] synonym: "Tub4 complex" EXACT [] is_a: GO:0008275 ! gamma-tubulin small complex intersection_of: GO:0008275 ! gamma-tubulin small complex intersection_of: part_of GO:0005816 ! spindle pole body relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0000930 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005815 ! microtubule organizing center [Term] id: GO:0000931 name: gamma-tubulin large complex namespace: cellular_component alt_id: GO:0000929 def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0000932 name: P-body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "cytoplasmic mRNA processing body" EXACT [] synonym: "P body" EXACT [] xref: Wikipedia:P_body is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule [Term] id: GO:0000933 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] is_a: GO:0030428 ! cell septum [Term] id: GO:0000934 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000935 name: division septum namespace: cellular_component def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw] synonym: "complete septum" EXACT [] synonym: "divison septum" EXACT [] is_a: GO:0030428 ! cell septum intersection_of: GO:0030428 ! cell septum intersection_of: part_of GO:0032153 ! cell division site relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0000935 ! division septum [Term] id: GO:0000937 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] is_a: GO:0000934 ! porous cell septum [Term] id: GO:0000938 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0000939 name: condensed chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore of condensed chromosome" EXACT [] synonym: "inner kinetochore plate" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000940 name: condensed chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore of condensed chromosome" EXACT [] synonym: "outer kinetochore plate" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000941 name: condensed nuclear chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [] is_a: GO:0000939 ! condensed chromosome inner kinetochore intersection_of: GO:0000939 ! condensed chromosome inner kinetochore intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000942 name: condensed nuclear chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [] is_a: GO:0000940 ! condensed chromosome outer kinetochore intersection_of: GO:0000940 ! condensed chromosome outer kinetochore intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000943 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: Wikipedia:Virus-like_particle is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000947 name: amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0000948 name: amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0000949 name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000950 name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000951 name: methionine catabolic process to 3-methylthiopropanol namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000952 name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000953 name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000954 name: methionine catabolic process to 3-methylthiopropanoate namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009087 ! methionine catabolic process is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000955 name: amino acid catabolic process via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process intersection_of: GO:0006401 ! RNA catabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000958 name: mitochondrial mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0006402 ! mRNA catabolic process intersection_of: GO:0006402 ! mRNA catabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process intersection_of: GO:0016070 ! RNA metabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:1902369 ! negative regulation of RNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing is_a: GO:0140053 ! mitochondrial gene expression intersection_of: GO:0006396 ! RNA processing intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000964 name: mitochondrial RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 5' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0000966 ! RNA 5'-end processing intersection_of: GO:0000966 ! RNA 5'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing intersection_of: GO:0031123 ! RNA 3'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0000968 name: tRNA exon ligation namespace: biological_process def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc] is_a: GO:0000378 ! RNA exon ligation relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation created_by: kchris creation_date: 2009-04-28T10:22:40Z [Term] id: GO:0000969 name: tRNA exon ligation utilizing ATP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:29:37Z [Term] id: GO:0000970 name: tRNA exon ligation utilizing GTP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:33:25Z [Term] id: GO:0000971 name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:36:17Z [Term] id: GO:0000972 name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] is_a: GO:0051276 ! chromosome organization created_by: kchris creation_date: 2009-09-10T12:25:11Z [Term] id: GO:0000973 name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery created_by: kchris creation_date: 2009-09-10T12:28:04Z [Term] id: GO:0000974 name: Prp19 complex namespace: cellular_component def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] synonym: "nineteen complex" NARROW [] synonym: "NTC" RELATED [] synonym: "Prp19/CDC5 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex created_by: kchris creation_date: 2009-10-12T10:01:30Z [Term] id: GO:0000976 name: transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0044212 ! transcription regulatory region DNA binding is_a: GO:1990837 ! sequence-specific double-stranded DNA binding created_by: kchris creation_date: 2010-08-10T11:00:02Z [Term] id: GO:0000977 name: RNA polymerase II regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding created_by: kchris creation_date: 2010-08-10T11:05:36Z [Term] id: GO:0000978 name: RNA polymerase II cis-regulatory region sequence-specific DNA binding namespace: molecular_function alt_id: GO:0000980 def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to cis-regulatory sequences. In bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is usually a synonym for "enhancer". synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED [] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding created_by: kchris creation_date: 2010-08-10T02:17:19Z [Term] id: GO:0000979 name: RNA polymerase II core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene." [GOC:pg, GOC:txnOH, PMID:12381658] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding created_by: kchris creation_date: 2010-08-10T02:17:28Z [Term] id: GO:0000981 name: DNA-binding transcription factor activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0000982 alt_id: GO:0001133 alt_id: GO:0001200 alt_id: GO:0001201 alt_id: GO:0001202 alt_id: GO:0001203 alt_id: GO:0003705 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15530 and https://github.com/geneontology/go-ontology/issues/16152; changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding" EXACT [] synonym: "RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" NARROW [] synonym: "sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] synonym: "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity" RELATED [] synonym: "transcription factor" BROAD [GOC:vw] synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] synonym: "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] is_a: GO:0003700 ! DNA-binding transcription factor activity relationship: has_part GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0006357 ! regulation of transcription by RNA polymerase II created_by: kchris creation_date: 2010-08-10T02:37:21Z [Term] id: GO:0000984 name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds and the " promoter cis-regulatory region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding created_by: kchris creation_date: 2010-08-10T02:58:18Z [Term] id: GO:0000985 name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a bacterial gene." [GOC:pg, GOC:txnOH] synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding created_by: kchris creation_date: 2010-08-10T03:01:38Z [Term] id: GO:0000986 name: bacterial-type cis-regulatory region sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001150 def: "Interacting selectively and non-covalently with a specific upstream cis-regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the promoter of a bacterial gene (or cistron, or operon)." [GOC:txnOH-2018] synonym: "bacterial-type proximal promoter sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding" EXACT [] synonym: "bacterial-type RNA polymerase enhancer sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" NARROW [] synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding created_by: kchris creation_date: 2011-01-27T03:42:53Z [Term] id: GO:0000987 name: cis-regulatory region sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001158 alt_id: GO:0001159 def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter." [GOC:txnOH-2018] synonym: "core promoter proximal region DNA binding" NARROW [] synonym: "core promoter proximal region sequence-specific DNA binding" NARROW [] synonym: "enhancer sequence-specific DNA binding" RELATED [] synonym: "promoter proximal region sequence-specific DNA binding" NARROW [] synonym: "proximal promoter sequence-specific DNA binding" NARROW [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0035326 ! cis-regulatory region binding created_by: kchris creation_date: 2010-08-10T03:40:16Z [Term] id: GO:0000988 name: obsolete transcription factor activity, protein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "protein binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] is_obsolete: true consider: GO:0005515 consider: GO:0140110 created_by: kchris creation_date: 2010-08-10T04:03:22Z [Term] id: GO:0000989 name: obsolete transcription factor activity, transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "transcription factor binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0008134 consider: GO:0140110 created_by: kchris creation_date: 2010-08-10T04:57:43Z [Term] id: GO:0000990 name: obsolete transcription factor activity, core RNA polymerase binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "core RNA polymerase binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0043175 consider: GO:0140110 created_by: kchris creation_date: 2010-08-10T05:01:03Z [Term] id: GO:0000991 name: obsolete transcription factor activity, core RNA polymerase II binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "core RNA polymerase II binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000993 consider: GO:0140110 created_by: kchris creation_date: 2010-08-10T05:03:45Z [Term] id: GO:0000992 name: RNA polymerase III cis-regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659] comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding created_by: kchris creation_date: 2010-08-11T03:49:28Z [Term] id: GO:0000993 name: RNA polymerase II complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH] synonym: "RNA polymerase II core binding" EXACT [] synonym: "RNAP II core binding" EXACT [] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-08-11T03:57:27Z [Term] id: GO:0000994 name: RNA polymerase III core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-08-11T03:58:58Z [Term] id: GO:0000995 name: RNA polymerase III general transcription initiation factor activity namespace: molecular_function alt_id: GO:0001034 def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC." [GOC:txnOH-2018, PMID:12381659, Wikipedia:RNA_polymerase_III] comment: Changed label, definition, see https://github.com/geneontology/go-ontology/issues/15789 synonym: "core RNA polymerase III binding transcription factor activity" NARROW [] synonym: "RNA polymerase III general initiation factor activity" EXACT [] synonym: "RNA polymerase III transcription factor activity, sequence-specific DNA binding" NARROW [] synonym: "sequence-specific DNA binding RNA polymerase III transcription factor activity" NARROW [] synonym: "transcription factor activity, core RNA polymerase III binding" NARROW [] is_a: GO:0140223 ! general transcription initiation factor activity relationship: part_of GO:0006383 ! transcription by RNA polymerase III created_by: kchris creation_date: 2010-08-23T03:41:48Z [Term] id: GO:0001000 name: bacterial-type RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH] comment: Should omega be included here? synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT [] is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-08-17T04:59:00Z [Term] id: GO:0001001 name: mitochondrial single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182] is_a: GO:0001050 ! single-subunit type RNA polymerase binding created_by: kchris creation_date: 2010-08-17T05:01:28Z [Term] id: GO:0001002 name: RNA polymerase III type 1 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding created_by: kchris creation_date: 2010-08-18T05:38:20Z [Term] id: GO:0001003 name: RNA polymerase III type 2 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding created_by: kchris creation_date: 2010-08-18T05:51:18Z [Term] id: GO:0001004 name: RNA polymerase III transcription regulator recruiting activity namespace: molecular_function alt_id: GO:0001005 alt_id: GO:0001008 alt_id: GO:0001033 alt_id: GO:0001038 alt_id: GO:0001157 def: "Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB." [GOC:txnOH-2018, PMID:12381659, PMID:23063749, PMID:27911719, Wikipedia:RNA_polymerase_III] comment: Merged terms as in https://github.com/geneontology/go-ontology/issues/14852 synonym: "RNA polymerase III assembly factor activity" RELATED [] synonym: "RNA polymerase III assembly factor activity, TFIIIB recruiting" RELATED [] synonym: "RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity" NARROW [] synonym: "SNAPc-type activity" RELATED [] synonym: "TFIIIA activity" RELATED [] synonym: "TFIIIC-type activity" RELATED [] synonym: "transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting" EXACT [] synonym: "transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] synonym: "transcription factor activity, RNA polymerase III type 1 promoter TFIIIB" RELATED [] synonym: "transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] synonym: "transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting" NARROW [] synonym: "type 2 RNA polymerase III promoter recognition" NARROW [] synonym: "type 3 RNA polymerase III promoter recognition" NARROW [] is_a: GO:0001134 ! transcription regulator recruiting activity relationship: part_of GO:0070898 ! RNA polymerase III preinitiation complex assembly created_by: kchris creation_date: 2010-08-18T05:53:32Z [Term] id: GO:0001006 name: RNA polymerase III type 3 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding created_by: kchris creation_date: 2010-08-18T06:02:26Z [Term] id: GO:0001007 name: obsolete transcription factor activity, RNA polymerase III transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase III transcription factor binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-08-18T06:24:07Z [Term] id: GO:0001010 name: RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity namespace: molecular_function def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH] synonym: "sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, sequence-specific DNA binding transcription factor recruiting" EXACT [] synonym: "transcription factor activity, sequence-specific DNA-binding transcription factor recruiting" RELATED [] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding created_by: kchris creation_date: 2010-08-18T06:46:33Z [Term] id: GO:0001011 name: obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH] comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent. synonym: "sequence-specific DNA binding RNA polymerase recruiting transcription factor activity" EXACT [] is_obsolete: true consider: GO:0140223 created_by: kchris creation_date: 2010-08-18T06:49:16Z [Term] id: GO:0001012 name: RNA polymerase II regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-19T09:43:58Z [Term] id: GO:0001013 name: RNA polymerase I regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-19T09:44:02Z [Term] id: GO:0001014 name: snoRNA transcription by RNA polymerase III namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH] synonym: "snoRNA transcription from a type 2 RNA polymerase III promoter" NARROW [] is_a: GO:0006383 ! transcription by RNA polymerase III is_a: GO:0009302 ! snoRNA transcription created_by: kchris creation_date: 2010-08-18T07:13:45Z [Term] id: GO:0001015 name: snoRNA transcription by RNA polymerase II namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "snoRNA transcription from an RNA polymerase II promoter" EXACT [] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0009302 ! snoRNA transcription created_by: kchris creation_date: 2010-08-18T07:21:18Z [Term] id: GO:0001016 name: RNA polymerase III regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-19T09:36:17Z [Term] id: GO:0001017 name: bacterial-type RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-19T09:45:42Z [Term] id: GO:0001018 name: mitochondrial promoter sequence-specific DNA binding namespace: molecular_function alt_id: GO:0000997 alt_id: GO:0001044 alt_id: GO:0001045 alt_id: GO:0070361 alt_id: GO:0070362 alt_id: GO:0070363 alt_id: GO:0070364 def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of the mitochondrial DNA." [GOC:txnOH, GOC:vw, PMID:20056105] synonym: "HSP coding strand binding" NARROW [PMID:9485316] synonym: "HSP non-coding strand binding" NARROW [PMID:9485316] synonym: "HSPas binding" NARROW [PMID:9485316] synonym: "HSPs binding" NARROW [PMID:9485316] synonym: "LSP coding strand binding" NARROW [PMID:9485316] synonym: "LSP non-coding strand binding" NARROW [PMID:9485316] synonym: "LSPas binding" NARROW [PMID:9485316] synonym: "LSPs binding" NARROW [PMID:9485316] synonym: "mitochondrial heavy strand promoter anti-sense binding" NARROW [] synonym: "mitochondrial heavy strand promoter sense binding" NARROW [] synonym: "mitochondrial light strand promoter anti-sense binding" NARROW [] synonym: "mitochondrial light strand promoter sense binding" NARROW [] synonym: "mitochondrial proximal promoter sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase regulatory region DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-25T04:11:49Z [Term] id: GO:0001019 name: plastid RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-19T09:46:27Z [Term] id: GO:0001025 name: RNA polymerase III general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH] synonym: "RNA polymerase III transcription factor binding" BROAD [] is_a: GO:0140296 ! general transcription initiation factor binding created_by: kchris creation_date: 2010-08-20T03:26:50Z [Term] id: GO:0001026 name: obsolete TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH] comment: This term was obsoleted because it represents a gene product. synonym: "RNA polymerase III recruiting transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-08-23T12:24:31Z [Term] id: GO:0001027 name: obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true created_by: kchris creation_date: 2010-08-23T12:50:20Z [Term] id: GO:0001028 name: obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true created_by: kchris creation_date: 2010-08-23T12:52:01Z [Term] id: GO:0001029 name: obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true created_by: kchris creation_date: 2010-08-23T12:52:40Z [Term] id: GO:0001030 name: RNA polymerase III type 1 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding is_a: GO:0080084 ! 5S rDNA binding created_by: kchris creation_date: 2010-08-23T12:58:54Z [Term] id: GO:0001031 name: RNA polymerase III type 2 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding created_by: kchris creation_date: 2010-08-23T01:14:56Z [Term] id: GO:0001032 name: RNA polymerase III type 3 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding created_by: kchris creation_date: 2010-08-23T01:15:14Z [Term] id: GO:0001037 name: RNA polymerase III hybrid type promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding created_by: kchris creation_date: 2010-08-24T02:51:34Z [Term] id: GO:0001039 name: RNA polymerase III hybrid type promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding created_by: kchris creation_date: 2010-08-23T06:21:24Z [Term] id: GO:0001040 name: obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. is_obsolete: true created_by: kchris creation_date: 2010-08-23T06:28:23Z [Term] id: GO:0001042 name: RNA polymerase I core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-09-23T01:39:23Z [Term] id: GO:0001046 name: core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation include the "core promoter" where the basal transcription machinery binds, and the "cis-regulatory region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001047 ! core promoter binding created_by: kchris creation_date: 2010-08-25T04:17:44Z [Term] id: GO:0001047 name: core promoter binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2010-08-27T03:00:52Z [Term] id: GO:0001048 name: RNA polymerase IV core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-09-23T01:41:03Z [Term] id: GO:0001049 name: RNA polymerase V core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-09-23T01:41:08Z [Term] id: GO:0001050 name: single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] synonym: "SP6-type RNA polymerase binding" EXACT [] synonym: "T3-type RNA polymerase binding" EXACT [] synonym: "T3/T7 type RNA polymerase binding" EXACT [] synonym: "T7-type RNA polymerase binding" EXACT [] is_a: GO:0070063 ! RNA polymerase binding created_by: kchris creation_date: 2010-09-23T02:33:45Z [Term] id: GO:0001051 name: plastid single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] is_a: GO:0001050 ! single-subunit type RNA polymerase binding created_by: kchris creation_date: 2010-09-23T02:42:57Z [Term] id: GO:0001052 name: plastid PEP RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995] is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding created_by: kchris creation_date: 2010-09-23T02:49:31Z [Term] id: GO:0001054 name: RNA polymerase I activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0006360 ! transcription by RNA polymerase I relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0006360 ! transcription by RNA polymerase I created_by: kchris creation_date: 2010-09-23T03:36:11Z [Term] id: GO:0001055 name: RNA polymerase II activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] xref: Reactome:R-HSA-6814549 "Pre-snRNA transcript initiation, Integrator binding, LEC binding" xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0006366 ! transcription by RNA polymerase II relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0006366 ! transcription by RNA polymerase II created_by: kchris creation_date: 2010-09-23T03:44:23Z [Term] id: GO:0001056 name: RNA polymerase III activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [] xref: Reactome:R-HSA-1964482 "RNA polymerase III transcribes microbial dsDNA to dsRNA" is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0006383 ! transcription by RNA polymerase III relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0006383 ! transcription by RNA polymerase III created_by: kchris creation_date: 2010-09-23T03:44:47Z [Term] id: GO:0001057 name: RNA polymerase IV activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0001059 ! transcription by RNA polymerase IV relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0001059 ! transcription by RNA polymerase IV created_by: kchris creation_date: 2010-09-23T03:44:55Z [Term] id: GO:0001058 name: RNA polymerase V activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity intersection_of: part_of GO:0001060 ! transcription by RNA polymerase V relationship: occurs_in GO:0000790 ! nuclear chromatin relationship: part_of GO:0001060 ! transcription by RNA polymerase V created_by: kchris creation_date: 2010-09-23T03:45:01Z [Term] id: GO:0001059 name: transcription by RNA polymerase IV namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from RNA pol IV promoter" EXACT [] synonym: "transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated created_by: kchris creation_date: 2010-09-23T03:51:35Z [Term] id: GO:0001060 name: transcription by RNA polymerase V namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from RNA pol V promoter" EXACT [] synonym: "transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated created_by: kchris creation_date: 2010-09-23T03:54:04Z [Term] id: GO:0001061 name: bacterial-type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity relationship: part_of GO:0001121 ! bacterial transcription created_by: kchris creation_date: 2010-10-19T03:36:01Z [Term] id: GO:0001062 name: plastid PEP-A RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity relationship: part_of GO:0042793 ! plastid transcription created_by: kchris creation_date: 2010-10-19T03:38:49Z [Term] id: GO:0001063 name: plastid PEP-B RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity relationship: part_of GO:0042793 ! plastid transcription created_by: kchris creation_date: 2010-10-19T03:46:46Z [Term] id: GO:0001064 name: single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "T3/T7 type RNA polymerase activity" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity created_by: kchris creation_date: 2010-10-19T03:47:56Z [Term] id: GO:0001065 name: mitochondrial single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0001064 ! single subunit type RNA polymerase activity relationship: part_of GO:0006390 ! mitochondrial transcription created_by: kchris creation_date: 2010-10-19T03:50:51Z [Term] id: GO:0001066 name: plastid single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001064 ! single subunit type RNA polymerase activity relationship: part_of GO:0042793 ! plastid transcription created_by: kchris creation_date: 2010-10-19T03:54:57Z [Term] id: GO:0001067 name: regulatory region nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0003676 ! nucleic acid binding created_by: kchris creation_date: 2010-10-21T04:08:56Z [Term] id: GO:0001068 name: transcription regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0001069 ! regulatory region RNA binding created_by: kchris creation_date: 2010-10-21T04:15:32Z [Term] id: GO:0001069 name: regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003723 ! RNA binding created_by: kchris creation_date: 2010-10-21T04:17:01Z [Term] id: GO:0001070 name: RNA-binding transcription regulator activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences." [GOC:txnOH-2018, PMID:1756726] comment: Added taxon constraints, edited definition see https://github.com/geneontology/go-ontology/issues/15872 synonym: "RNA binding transcription factor activity" RELATED [] synonym: "RNA binding transcription regulator activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: has_part GO:0001068 ! transcription regulatory region RNA binding created_by: kchris creation_date: 2010-10-21T04:19:17Z [Term] id: GO:0001072 name: transcription antitermination factor activity, RNA binding namespace: molecular_function def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211] synonym: "RNA binding transcription antitermination factor activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: part_of GO:0031564 ! transcription antitermination created_by: kchris creation_date: 2010-10-21T04:48:17Z [Term] id: GO:0001073 name: transcription antitermination factor activity, DNA binding namespace: molecular_function def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211] synonym: "DNA binding transcription antitermination factor activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: part_of GO:0031564 ! transcription antitermination created_by: kchris creation_date: 2010-10-21T05:18:52Z [Term] id: GO:0001074 name: obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] comment: This term has been obsoleted because it represents a GO-CAM model, see https://github.com/geneontology/go-ontology/issues/16554 synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT [] synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-10-22T02:30:43Z [Term] id: GO:0001076 name: obsolete transcription factor activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001085 consider: GO:0140110 created_by: kchris creation_date: 2010-10-22T02:49:32Z [Term] id: GO:0001079 name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0090293 ! nitrogen catabolite regulation of transcription created_by: kchris creation_date: 2010-10-27T03:29:01Z [Term] id: GO:0001080 name: nitrogen catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090294 ! nitrogen catabolite activation of transcription created_by: kchris creation_date: 2010-10-27T03:32:34Z [Term] id: GO:0001081 name: nitrogen catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090295 ! nitrogen catabolite repression of transcription created_by: kchris creation_date: 2010-10-27T03:38:05Z [Term] id: GO:0001082 name: obsolete transcription factor activity, RNA polymerase I transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase I transcription factor binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-10-27T04:03:47Z [Term] id: GO:0001083 name: obsolete transcription factor activity, RNA polymerase II basal transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase II basal transcription factor binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-10-27T04:12:55Z [Term] id: GO:0001084 name: obsolete transcription factor activity, TFIID-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIID-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001094 created_by: kchris creation_date: 2010-10-27T04:15:22Z [Term] id: GO:0001085 name: RNA polymerase II transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding created_by: kchris creation_date: 2010-10-28T02:08:59Z [Term] id: GO:0001086 name: obsolete transcription factor activity, TFIIA-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIA-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001092 created_by: kchris creation_date: 2010-10-28T02:14:59Z [Term] id: GO:0001087 name: obsolete transcription factor activity, TFIIB-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIB-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001093 created_by: kchris creation_date: 2010-10-28T02:18:00Z [Term] id: GO:0001088 name: obsolete transcription factor activity, TFIIE-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIE-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001095 created_by: kchris creation_date: 2010-10-28T02:25:22Z [Term] id: GO:0001089 name: obsolete transcription factor activity, TFIIF-class transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIF-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001096 created_by: kchris creation_date: 2010-10-28T02:27:12Z [Term] id: GO:0001090 name: obsolete transcription factor activity, TFIIH-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIH-class binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2010-10-28T02:28:01Z [Term] id: GO:0001091 name: RNA polymerase II general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] synonym: "RNA polymerase II basal transcription factor binding" EXACT [] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0140296 ! general transcription initiation factor binding created_by: kchris creation_date: 2010-10-28T02:30:02Z [Term] id: GO:0001092 name: TFIIA-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] synonym: "TFIIA-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2010-10-28T02:37:19Z [Term] id: GO:0001093 name: TFIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding created_by: kchris creation_date: 2010-10-28T02:46:15Z [Term] id: GO:0001094 name: TFIID-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIID-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2010-10-28T02:48:33Z [Term] id: GO:0001095 name: TFIIE-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIE-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2010-10-28T02:49:20Z [Term] id: GO:0001096 name: TFIIF-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIF-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2010-10-28T02:51:20Z [Term] id: GO:0001097 name: TFIIH-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIH-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2010-10-28T02:51:41Z [Term] id: GO:0001098 name: basal transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0005515 ! protein binding created_by: kchris creation_date: 2010-11-24T12:50:49Z [Term] id: GO:0001099 name: basal RNA polymerase II transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. synonym: "basal RNAP II transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding created_by: kchris creation_date: 2010-11-24T12:54:33Z [Term] id: GO:0001100 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0045839 ! negative regulation of mitotic nuclear division is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010458 ! exit from mitosis relationship: negatively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn, http://en.wikipedia.org/wiki/Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001102 name: RNA polymerase II activating transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] is_a: GO:0033613 ! activating transcription factor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding created_by: kchris creation_date: 2010-11-24T02:17:08Z [Term] id: GO:0001103 name: RNA polymerase II repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding is_a: GO:0070491 ! repressing transcription factor binding created_by: kchris creation_date: 2010-11-24T02:34:55Z [Term] id: GO:0001108 name: bacterial-type RNA polymerase holo enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH] synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding created_by: kchris creation_date: 2010-11-30T04:26:04Z [Term] id: GO:0001109 name: promoter clearance during DNA-templated transcription namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter clearance during DNA-dependent transcription" EXACT [GOC:txnOH] synonym: "promoter escape" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: has_part GO:0001119 ! protein-DNA-RNA complex remodeling relationship: part_of GO:0006351 ! transcription, DNA-templated created_by: kchris creation_date: 2010-12-01T02:13:09Z [Term] id: GO:0001110 name: promoter clearance from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006383 ! transcription by RNA polymerase III created_by: kchris creation_date: 2010-12-01T03:08:29Z [Term] id: GO:0001111 name: promoter clearance from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] synonym: "promoter escape from RNA polymerase II promoter" EXACT [] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006366 ! transcription by RNA polymerase II created_by: kchris creation_date: 2010-12-01T03:09:31Z [Term] id: GO:0001112 name: DNA-templated transcriptional open complex formation namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "DNA-dependent transcriptional open complex formation" EXACT [GOC:txnOH] synonym: "promoter melting" BROAD [] is_a: GO:0001120 ! protein-DNA complex remodeling relationship: part_of GO:0006352 ! DNA-templated transcription, initiation created_by: kchris creation_date: 2010-12-02T02:15:04Z [Term] id: GO:0001113 name: transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "RNA polymerase II promoter melting" EXACT [] is_a: GO:0001112 ! DNA-templated transcriptional open complex formation relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter created_by: kchris creation_date: 2010-12-02T02:27:19Z [Term] id: GO:0001114 name: protein-DNA-RNA complex namespace: cellular_component def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH] is_a: GO:0032991 ! protein-containing complex created_by: kchris creation_date: 2010-12-03T02:09:38Z [Term] id: GO:0001115 name: protein-DNA-RNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH] synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization created_by: kchris creation_date: 2010-12-03T04:00:02Z [Term] id: GO:0001116 name: protein-DNA-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: kchris creation_date: 2010-12-03T04:01:38Z [Term] id: GO:0001117 name: protein-DNA-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0032984 ! protein-containing complex disassembly created_by: kchris creation_date: 2010-12-03T04:04:07Z [Term] id: GO:0001118 name: transcription ternary complex disassembly namespace: biological_process def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH] synonym: "transcription protein-DNA-RNA complex disassembly" EXACT [] is_a: GO:0001117 ! protein-DNA-RNA complex disassembly relationship: part_of GO:0006353 ! DNA-templated transcription, termination created_by: kchris creation_date: 2010-12-03T04:11:34Z [Term] id: GO:0001119 name: protein-DNA-RNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034367 ! protein-containing complex remodeling created_by: kchris creation_date: 2010-12-03T04:15:52Z [Term] id: GO:0001120 name: protein-DNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0034367 ! protein-containing complex remodeling is_a: GO:0071824 ! protein-DNA complex subunit organization created_by: kchris creation_date: 2010-12-03T04:17:15Z [Term] id: GO:0001121 name: bacterial transcription namespace: biological_process def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated created_by: kchris creation_date: 2010-12-06T03:32:13Z [Term] id: GO:0001122 name: promoter clearance from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0001121 ! bacterial transcription created_by: kchris creation_date: 2010-12-06T03:38:10Z [Term] id: GO:0001123 name: transcription initiation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0001121 ! bacterial transcription created_by: kchris creation_date: 2010-12-06T03:40:12Z [Term] id: GO:0001124 name: transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0001121 ! bacterial transcription created_by: kchris creation_date: 2010-12-06T03:46:27Z [Term] id: GO:0001125 name: transcription termination from bacterial-type RNA polymerase promoter namespace: biological_process def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0001121 ! bacterial transcription created_by: kchris creation_date: 2010-12-06T03:47:43Z [Term] id: GO:0001126 name: bacterial-type RNA polymerase preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription." [GOC:txnOH, PMID:18280161] synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT [] synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT [] synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter created_by: kchris creation_date: 2010-12-06T03:54:45Z [Term] id: GO:0001127 name: transcriptional open complex formation at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within a bacterial-type RNA polymerase promoter to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161] is_a: GO:0001112 ! DNA-templated transcriptional open complex formation relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter created_by: kchris creation_date: 2010-12-06T04:04:16Z [Term] id: GO:0001128 name: obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867] comment: This term was obsoleted because it represented a mix of function and process and is not annotated consistently synonym: "RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-01-20T02:13:36Z [Term] id: GO:0001129 name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW [] synonym: "TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-01-20T02:53:35Z [Term] id: GO:0001132 name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW [] synonym: "TBP-class protein binding RNA polymerase II transcription factor activity" EXACT [] synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW [] is_obsolete: true created_by: kchris creation_date: 2011-01-20T04:15:44Z [Term] id: GO:0001134 name: transcription regulator recruiting activity namespace: molecular_function def: "The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] comment: Changed subclasses https://github.com/geneontology/go-ontology/issues/15577 synonym: "transcription factor activity, transcription factor recruiting" RELATED [] synonym: "transcription factor recruiting activity" EXACT [] synonym: "transcription factor recruiting transcription factor activity" EXACT [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0140110 ! transcription regulator activity created_by: kchris creation_date: 2011-01-20T04:57:59Z [Term] id: GO:0001135 name: RNA polymerase II transcription regulator recruiting activity namespace: molecular_function alt_id: GO:0001136 alt_id: GO:0001137 alt_id: GO:0001138 def: "The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15795 synonym: "RNA polymerase II transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase II transcription factor recruiting transcription factor activity" EXACT [] synonym: "TFIIE-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "TFIIF-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "TFIIH-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "transcription factor activity, RNA polymerase II transcription factor recruiting" RELATED [] synonym: "transcription factor activity, TFIIE-class transcription factor recruiting" NARROW [] synonym: "transcription factor activity, TFIIF-class transcription factor recruiting" NARROW [] synonym: "transcription factor activity, TFIIH-class transcription factor recruiting" NARROW [] is_a: GO:0001134 ! transcription regulator recruiting activity relationship: part_of GO:0051123 ! RNA polymerase II preinitiation complex assembly created_by: kchris creation_date: 2011-01-20T05:13:12Z [Term] id: GO:0001139 name: RNA polymerase II complex recruiting activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] synonym: "core RNA polymerase II recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, core RNA polymerase II recruiting" RELATED [] is_a: GO:0000993 ! RNA polymerase II complex binding relationship: part_of GO:0051123 ! RNA polymerase II preinitiation complex assembly created_by: kchris creation_date: 2011-01-20T05:55:01Z [Term] id: GO:0001145 name: mitochondrial RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001146 def: "Interacting selectively and non-covalently with a DNA sequence that controls mitochondrial transcription termination." [GOC:txnOH-2018, PMID:18391175] synonym: "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding" EXACT [] is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding relationship: part_of GO:0006393 ! termination of mitochondrial transcription created_by: kchris creation_date: 2011-01-27T02:42:23Z [Term] id: GO:0001147 name: transcription termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175] comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001160 ! transcription termination site DNA binding created_by: kchris creation_date: 2011-01-27T02:48:26Z [Term] id: GO:0001148 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding created_by: kchris creation_date: 2011-01-27T03:04:07Z [Term] id: GO:0001149 name: obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] comment: This term was obsoleted because it was not clearly defined, see https://github.com/geneontology/go-ontology/issues/16730 synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-01-27T03:08:41Z [Term] id: GO:0001152 name: obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting namespace: molecular_function def: "OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659] comment: This term was made obsolete in the 2018 Transcription branch revision. This represents the activity of TFIIIA only. synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity" EXACT [] synonym: "TFIIIA activity" RELATED [] synonym: "type 1 RNA polymerase III promoter recognition" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-01-27T04:18:21Z [Term] id: GO:0001153 name: obsolete transcription factor activity, RNA polymerase III transcription factor recruiting namespace: molecular_function def: "OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH] comment: This term was made obsolete in the 2018 Transcription branch revision. This term was redundant with other terms. synonym: "RNA polymerase III transcription factor recruiting transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-01-27T04:45:37Z [Term] id: GO:0001154 name: TFIIIB-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] synonym: "TFIIIB-class transcription factor binding" EXACT [] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding created_by: kchris creation_date: 2011-01-27T04:53:50Z [Term] id: GO:0001155 name: TFIIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding created_by: kchris creation_date: 2011-01-27T04:57:49Z [Term] id: GO:0001156 name: TFIIIC-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] synonym: "TFIIIC-class transcription factor binding" EXACT [] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding created_by: kchris creation_date: 2011-01-27T05:02:22Z [Term] id: GO:0001160 name: transcription termination site DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: kchris creation_date: 2011-01-28T03:39:44Z [Term] id: GO:0001161 name: intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0044213 ! intronic transcription regulatory region DNA binding created_by: kchris creation_date: 2011-01-28T03:44:02Z [Term] id: GO:0001162 name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding created_by: kchris creation_date: 2011-01-28T03:46:19Z [Term] id: GO:0001163 name: RNA polymerase I regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding created_by: kchris creation_date: 2011-01-31T04:12:06Z [Term] id: GO:0001164 name: RNA polymerase I core promoter sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001187 def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I CORE element sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity" RELATED [] synonym: "RNA polymerase I core promoter sequence-specific DNA binding" EXACT [] synonym: "transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting" RELATED [] is_a: GO:0001046 ! core promoter sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding relationship: part_of GO:0001188 ! RNA polymerase I preinitiation complex assembly created_by: kchris creation_date: 2011-01-31T04:47:48Z [Term] id: GO:0001165 name: RNA polymerase I cis-regulatory region sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001166 def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I enhancer sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase I upstream control element sequence-specific DNA binding" RELATED [] synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED [] is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding created_by: kchris creation_date: 2011-01-31T05:29:59Z [Term] id: GO:0001167 name: obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "sequence-specific DNA binding RNA polymerase I transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-02-03T04:07:46Z [Term] id: GO:0001168 name: obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-02-03T04:10:23Z [Term] id: GO:0001169 name: obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-02-03T04:10:42Z [Term] id: GO:0001170 name: obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true created_by: kchris creation_date: 2011-02-03T04:10:59Z [Term] id: GO:0001171 name: reverse transcription namespace: biological_process def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252] xref: Wikipedia:Reverse_transcription is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process relationship: has_part GO:0003964 ! RNA-directed DNA polymerase activity relationship: has_part GO:0004533 ! exoribonuclease H activity created_by: kchris creation_date: 2011-03-14T03:51:08Z [Term] id: GO:0001172 name: transcription, RNA-templated namespace: biological_process def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH] synonym: "transcription, RNA-dependent" EXACT [GOC:txnOH] is_a: GO:0097659 ! nucleic acid-templated transcription created_by: kchris creation_date: 2011-03-14T03:54:46Z [Term] id: GO:0001173 name: DNA-templated transcriptional start site selection namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] synonym: "DNA-dependent transcriptional start site selection" EXACT [GOC:txnOH] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006352 ! DNA-templated transcription, initiation created_by: kchris creation_date: 2011-06-20T12:44:11Z [Term] id: GO:0001174 name: transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter created_by: kchris creation_date: 2011-06-20T01:35:28Z [Term] id: GO:0001175 name: transcriptional start site selection at RNA polymerase III promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter created_by: kchris creation_date: 2011-06-20T01:47:38Z [Term] id: GO:0001176 name: transcriptional start site selection at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter created_by: kchris creation_date: 2011-06-20T01:48:56Z [Term] id: GO:0001177 name: regulation of transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter relationship: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter created_by: kchris creation_date: 2011-06-20T02:01:18Z [Term] id: GO:0001178 name: regulation of transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter created_by: kchris creation_date: 2011-06-20T02:06:00Z [Term] id: GO:0001179 name: RNA polymerase I general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH] synonym: "RNA polymerase I transcription factor binding" BROAD [] is_a: GO:0140296 ! general transcription initiation factor binding created_by: kchris creation_date: 2011-08-12T03:03:03Z [Term] id: GO:0001181 name: RNA polymerase I general transcription initiation factor activity namespace: molecular_function def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3." [GOC:txnOH-2018, PMID:11500378, PMID:28340337, PMID:28842442] comment: Updated class label and definition, see https://github.com/geneontology/go-ontology/issues/14736 synonym: "core RNA polymerase I binding transcription factor activity" BROAD [] synonym: "general RNA polymerase I transcription factor activity" EXACT [] synonym: "RNA polymerase I transcription general initiation factor activity" EXACT [] synonym: "transcription factor activity, core RNA polymerase I binding" BROAD [] is_a: GO:0140223 ! general transcription initiation factor activity relationship: part_of GO:0006360 ! transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-12T04:13:30Z [Term] id: GO:0001182 name: promoter clearance from RNA polymerase I promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006360 ! transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-15T03:49:28Z [Term] id: GO:0001183 name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH] is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-15T03:57:25Z [Term] id: GO:0001184 name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-15T04:03:52Z [Term] id: GO:0001186 name: RNA polymerase I transcription regulator recruiting activity namespace: molecular_function def: "The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:12381659, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase I transcription factor recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, RNA polymerase I transcription factor recruiting" RELATED [] is_a: GO:0001134 ! transcription regulator recruiting activity is_a: GO:0001179 ! RNA polymerase I general transcription initiation factor binding relationship: part_of GO:0001188 ! RNA polymerase I preinitiation complex assembly created_by: kchris creation_date: 2011-08-24T04:00:18Z [Term] id: GO:0001188 name: RNA polymerase I preinitiation complex assembly namespace: biological_process alt_id: GO:0001189 def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I transcriptional preinitiation complex assembly" EXACT [] synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript" NARROW [] synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript" NARROW [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter created_by: kchris creation_date: 2011-08-24T04:16:28Z [Term] id: GO:0001190 name: obsolete transcriptional activator activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription activator activity" EXACT [] synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription" EXACT [] is_obsolete: true consider: GO:0001085 consider: GO:0001228 created_by: kchris creation_date: 2011-08-25T02:07:14Z [Term] id: GO:0001191 name: obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT [] synonym: "RNA polymerase II transcription factor binding transcription repressor activity" EXACT [] synonym: "RNA polymerase II transcription repressor activity" BROAD [] is_obsolete: true consider: GO:0001085 consider: GO:0001227 created_by: kchris creation_date: 2011-08-25T02:12:30Z [Term] id: GO:0001192 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation" EXACT [GOC:txnOH] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006354 ! DNA-templated transcription, elongation created_by: kchris creation_date: 2011-09-02T02:25:30Z [Term] id: GO:0001193 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter created_by: kchris creation_date: 2011-09-02T02:31:00Z [Term] id: GO:0001194 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0001124 ! transcription elongation from bacterial-type RNA polymerase promoter created_by: kchris creation_date: 2011-09-02T02:37:59Z [Term] id: GO:0001195 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter created_by: kchris creation_date: 2011-09-02T02:41:29Z [Term] id: GO:0001196 name: regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated intersection_of: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II created_by: kchris creation_date: 2011-11-23T09:25:32Z [Term] id: GO:0001197 name: positive regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated intersection_of: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II created_by: kchris creation_date: 2011-11-23T09:31:33Z [Term] id: GO:0001198 name: negative regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated intersection_of: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II created_by: kchris creation_date: 2011-11-23T09:36:06Z [Term] id: GO:0001207 name: histone displacement namespace: biological_process def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0034728 ! nucleosome organization created_by: karen creation_date: 2012-03-27T10:56:56Z [Term] id: GO:0001208 name: histone H2A-H2B dimer displacement namespace: biological_process def: "The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0001207 ! histone displacement created_by: karen creation_date: 2012-03-27T11:03:40Z [Term] id: GO:0001216 name: DNA-binding transcription activator activity namespace: molecular_function alt_id: GO:0001140 alt_id: GO:0001215 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] comment: Merged terms as requested in https://github.com/geneontology/go-ontology/issues/16534\nMade term more general see https://github.com/geneontology/go-ontology/issues/16736 synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" RELATED [] is_a: GO:0003700 ! DNA-binding transcription factor activity relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated created_by: kchris creation_date: 2011-01-26T03:09:27Z [Term] id: GO:0001217 name: DNA-binding transcription repressor activity namespace: molecular_function alt_id: GO:0001141 alt_id: GO:0001218 alt_id: GO:0001219 alt_id: GO:0001220 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] comment: Made term more general see https://github.com/geneontology/go-ontology/issues/16736 synonym: "bacterial-type DNA binding transcription repressor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding" NARROW [] synonym: "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] is_a: GO:0003700 ! DNA-binding transcription factor activity relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated created_by: kchris creation_date: 2011-01-26T03:15:45Z [Term] id: GO:0001221 name: transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0008134 ! transcription factor binding created_by: kchris creation_date: 2012-04-16T03:19:05Z [Term] id: GO:0001222 name: transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding created_by: kchris creation_date: 2012-04-16T03:27:26Z [Term] id: GO:0001223 name: transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding created_by: kchris creation_date: 2012-04-16T03:30:16Z [Term] id: GO:0001224 name: RNA polymerase II transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding created_by: kchris creation_date: 2012-04-16T03:37:06Z [Term] id: GO:0001225 name: RNA polymerase II transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001223 ! transcription coactivator binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding created_by: kchris creation_date: 2012-04-16T03:39:41Z [Term] id: GO:0001226 name: RNA polymerase II transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001222 ! transcription corepressor binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding created_by: kchris creation_date: 2012-04-16T03:39:47Z [Term] id: GO:0001227 name: DNA-binding transcription repressor activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0001078 alt_id: GO:0001206 alt_id: GO:0001210 alt_id: GO:0001214 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 and https://github.com/geneontology/go-ontology/issues/16152\nMerge terms see https://github.com/geneontology/go-ontology/issues/16534 synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT [] synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific is_a: GO:0001217 ! DNA-binding transcription repressor activity relationship: part_of GO:0000122 ! negative regulation of transcription by RNA polymerase II created_by: kchris creation_date: 2010-10-26T03:56:48Z [Term] id: GO:0001228 name: DNA-binding transcription activator activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0001077 alt_id: GO:0001205 alt_id: GO:0001209 alt_id: GO:0001211 alt_id: GO:0001212 alt_id: GO:0001213 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Merged terms, see https://github.com/geneontology/go-ontology/issues/16152 and https://github.com/geneontology/go-ontology/issues/16534; changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT [] synonym: "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific is_a: GO:0001216 ! DNA-binding transcription activator activity relationship: part_of GO:0045944 ! positive regulation of transcription by RNA polymerase II created_by: kchris creation_date: 2012-01-26T03:10:20Z [Term] id: GO:0001300 name: chronological cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] synonym: "chronological cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001301 name: progressive alteration of chromatin involved in cell aging namespace: biological_process def: "Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, GOC:vw, PMID:12044938] synonym: "age-dependent accumulation of genetic damage" RELATED [] synonym: "progressive alteration of chromatin during cell ageing" EXACT [] synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006325 ! chromatin organization intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0007569 ! cell aging relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0001302 name: replicative cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] synonym: "replicative cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001303 name: nucleolar fragmentation involved in replicative aging namespace: biological_process def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] synonym: "nucleolar fragmentation during replicative ageing" RELATED [] synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007576 ! nucleolar fragmentation intersection_of: GO:0007576 ! nucleolar fragmentation intersection_of: part_of GO:0001302 ! replicative cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001304 name: progressive alteration of chromatin involved in replicative cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging intersection_of: part_of GO:0001302 ! replicative cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001305 name: progressive alteration of chromatin involved in chronological cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging intersection_of: part_of GO:0001300 ! chronological cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001306 name: age-dependent response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] is_a: GO:0006979 ! response to oxidative stress relationship: part_of GO:0007571 ! age-dependent general metabolic decline [Term] id: GO:0001307 name: extrachromosomal circular DNA accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging [Term] id: GO:0001308 name: negative regulation of chromatin silencing involved in replicative cell aging namespace: biological_process def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT [] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0031936 ! negative regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006342 ! chromatin silencing intersection_of: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001309 name: obsolete age-dependent telomere shortening namespace: biological_process def: "OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] comment: This term was made obsolete because it represents a phenotype. synonym: "age-dependent telomere shortening" EXACT [] is_obsolete: true consider: GO:1903824 [Term] id: GO:0001310 name: extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001311 name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging is_a: GO:0045458 ! recombination within rDNA repeats relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001312 name: replication of extrachromosomal rDNA circles involved in replicative cell aging namespace: biological_process def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001313 name: formation of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT [] synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001325 ! formation of extrachromosomal circular DNA intersection_of: GO:0001325 ! formation of extrachromosomal circular DNA intersection_of: part_of GO:0001302 ! replicative cell aging relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001314 name: replication of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001326 ! replication of extrachromosomal circular DNA intersection_of: GO:0001326 ! replication of extrachromosomal circular DNA intersection_of: part_of GO:0001302 ! replicative cell aging relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001315 name: age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] synonym: "age-dependent response to active oxygen species" EXACT [] synonym: "age-dependent response to AOS" EXACT [] synonym: "age-dependent response to reactive oxidative species" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] synonym: "age-dependent response to ROI" EXACT [] synonym: "age-dependent response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001306 ! age-dependent response to oxidative stress [Term] id: GO:0001316 name: age-dependent response to reactive oxygen species involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001317 name: accumulation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging [Term] id: GO:0001318 name: formation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001319 name: inheritance of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0008104 ! protein localization relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001320 name: age-dependent response to reactive oxygen species involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species intersection_of: GO:0001315 ! age-dependent response to reactive oxygen species intersection_of: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001321 name: age-dependent general metabolic decline involved in replicative cell aging namespace: biological_process def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline intersection_of: GO:0007571 ! age-dependent general metabolic decline intersection_of: part_of GO:0001302 ! replicative cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001322 name: age-dependent response to oxidative stress involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress intersection_of: GO:0001306 ! age-dependent response to oxidative stress intersection_of: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging relationship: part_of GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0001323 name: age-dependent general metabolic decline involved in chronological cell aging namespace: biological_process def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline intersection_of: GO:0007571 ! age-dependent general metabolic decline intersection_of: part_of GO:0001300 ! chronological cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001324 name: age-dependent response to oxidative stress involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress intersection_of: GO:0001306 ! age-dependent response to oxidative stress intersection_of: part_of GO:0001300 ! chronological cell aging relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging [Term] id: GO:0001325 name: formation of extrachromosomal circular DNA namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] synonym: "assembly of extrachromosomal circular DNA" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0001326 name: replication of extrachromosomal circular DNA namespace: biological_process def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] is_a: GO:0006260 ! DNA replication [Term] id: GO:0001400 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0001401 name: SAM complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "mitochondrial sorting and assembly machinery complex" EXACT [] synonym: "TOB complex" EXACT [] is_a: GO:0098799 ! outer mitochondrial membrane protein complex [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0030447 ! filamentous growth relationship: part_of GO:0030447 ! filamentous growth [Term] id: GO:0001403 name: invasive growth in response to glucose limitation namespace: biological_process def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. subset: goslim_yeast synonym: "colony morphology" RELATED [] is_a: GO:0036267 ! invasive filamentous growth [Term] id: GO:0001404 name: obsolete invasive growth namespace: biological_process def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] comment: This term was made obsolete because more appropriate terms were created. synonym: "invasive growth" EXACT [] synonym: "tissue invasion" EXACT [] is_obsolete: true consider: GO:0044409 [Term] id: GO:0001405 name: PAM complex, Tim23 associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix." [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] synonym: "presequence translocase-associated import motor" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005744 ! TIM23 mitochondrial import inner membrane translocase complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0001406 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity relationship: part_of GO:0001407 ! glycerophosphodiester transmembrane transport [Term] id: GO:0001407 name: glycerophosphodiester transmembrane transport namespace: biological_process def: "The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0001408 name: guanine nucleotide transport namespace: biological_process def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0001409 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other." [GOC:mcc] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity relationship: part_of GO:1903790 ! guanine nucleotide transmembrane transport [Term] id: GO:0001410 name: chlamydospore formation namespace: biological_process alt_id: GO:0055027 def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] synonym: "chlamydospore development" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/] synonym: "skeletal development" EXACT [] xref: MIPS_funcat:47.03.17 is_a: GO:0048731 ! system development [Term] id: GO:0001502 name: cartilage condensation namespace: biological_process def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] is_a: GO:0098743 ! cell aggregation relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: MIPS_funcat:41.05.17 xref: MIPS_funcat:45.03.05.07 xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] subset: goslim_synapse synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0098657 ! import into cell [Term] id: GO:0001505 name: regulation of neurotransmitter levels namespace: biological_process def: "Any process that modulates levels of neurotransmitter." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0001506 name: obsolete neurotransmitter biosynthetic process and storage namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] comment: This term was made obsolete because it is an amalgamation of its two children. synonym: "neurotransmitter anabolism and storage" EXACT [] synonym: "neurotransmitter biosynthetic process and storage" EXACT [] synonym: "neurotransmitter formation and storage" EXACT [] synonym: "neurotransmitter synthesis and storage" EXACT [] is_obsolete: true consider: GO:0042136 consider: GO:0042137 [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process intersection_of: GO:0006581 ! acetylcholine catabolic process intersection_of: occurs_in GO:0043083 ! synaptic cleft relationship: occurs_in GO:0043083 ! synaptic cleft relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. xref: MIPS_funcat:34.03.03 is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001509 name: obsolete legumain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] comment: This term was made obsolete because it represents a gene product. synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "legumain activity" EXACT [] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0001511 name: obsolete fibrillin namespace: molecular_function def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "fibrillin" EXACT [] is_obsolete: true consider: GO:0001527 consider: GO:0005509 [Term] id: GO:0001512 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN xref: Reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0001514 name: selenocysteine incorporation namespace: biological_process def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] xref: RESID:AA0022 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0001516 name: prostaglandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] synonym: "prostaglandin anabolism" EXACT [] synonym: "prostaglandin biosynthesis" EXACT [] synonym: "prostaglandin formation" EXACT [] synonym: "prostaglandin synthesis" EXACT [] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0046457 ! prostanoid biosynthetic process [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] subset: goslim_chembl synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: Reactome:R-HSA-2046222 "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG" xref: Reactome:R-HSA-3656269 "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG" xref: Reactome:R-HSA-6786012 "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0001519 name: peptide amidation namespace: biological_process def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] is_a: GO:0031179 ! peptide modification [Term] id: GO:0001520 name: outer dense fiber namespace: cellular_component def: "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins." [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759] synonym: "outer dense fibre" EXACT [] is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0036126 ! sperm flagellum [Term] id: GO:0001522 name: pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] synonym: "pseudouridylation" EXACT [] xref: Wikipedia:Pseudouridine xref: Wikipedia:Pseudouridylation is_a: GO:0009451 ! RNA modification [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732] synonym: "retinoid metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001524 name: obsolete globin namespace: molecular_function def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "globin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001526 name: obsolete proteoglycan sulfate transfer namespace: biological_process def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] comment: This term was made obsolete because it represents a group of molecular functions. synonym: "proteoglycan sulfate transfer" EXACT [] synonym: "proteoglycan sulphate transfer" EXACT [] is_obsolete: true consider: GO:0006029 consider: GO:0006790 consider: GO:0050698 [Term] id: GO:0001527 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [PMID:27026396] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0031012 ! extracellular matrix [Term] id: GO:0001528 name: obsolete elastin namespace: molecular_function def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "elastin" EXACT [] is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001529 name: obsolete elastin namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "elastin" EXACT [] is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001530 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0001531 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0001532 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-21 receptor activity" EXACT [GOC:mah] synonym: "IL-21R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019977 ! interleukin-21 binding relationship: part_of GO:0038114 ! interleukin-21-mediated signaling pathway [Term] id: GO:0001533 name: cornified envelope namespace: cellular_component def: "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] is_a: GO:0005886 ! plasma membrane [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0001535 name: radial spoke head namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:cilia, GOC:hjd, GOC:krc] synonym: "radial spokehead" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001536 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001537 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: Reactome:R-HSA-2022063 "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS" xref: Reactome:R-HSA-3636919 "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS" xref: Reactome:R-HSA-6786034 "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "ciliary or bacterial-type flagellar motility" RELATED [] synonym: "ciliary/flagellar motility" EXACT [] xref: MIPS_funcat:34.05.07 is_a: GO:0048870 ! cell motility [Term] id: GO:0001540 name: amyloid-beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor." [GOC:hjd] subset: goslim_chembl synonym: "beta-amyloid binding" EXACT [] is_a: GO:0042277 ! peptide binding [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] synonym: "follicular phase" RELATED [] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001542 name: ovulation from ovarian follicle namespace: biological_process def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030728 ! ovulation relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001543 name: ovarian follicle rupture namespace: biological_process def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001542 ! ovulation from ovarian follicle [Term] id: GO:0001544 name: initiation of primordial ovarian follicle growth namespace: biological_process def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0048162 ! multi-layer follicle stage [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001548 name: follicular fluid formation in ovarian follicle antrum namespace: biological_process def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001550 name: ovarian cumulus expansion namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001551 name: ovarian follicle endowment namespace: biological_process def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, http://ovary.stanford.edu, PMID:18638134] is_a: GO:0003006 ! developmental process involved in reproduction relationship: has_part GO:0097191 ! extrinsic apoptotic signaling pathway relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001554 name: luteolysis namespace: biological_process def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764] xref: Wikipedia:Luteolysis is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001557 name: obsolete metabolic process resulting in cell growth namespace: biological_process def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. synonym: "metabolic process resulting in cell growth" EXACT [] is_obsolete: true consider: GO:0008152 consider: GO:0016049 [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001559 name: regulation of cell growth by detection of nuclear:cytoplasmic ratio namespace: biological_process def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] xref: MIPS_funcat:40.01.05.02 is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0016475 ! detection of nuclear:cytoplasmic ratio intersection_of: regulates GO:0016049 ! cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] xref: MIPS_funcat:40.01.05.01 is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001561 name: fatty acid alpha-oxidation namespace: biological_process def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] xref: MetaCyc:PWY-2501 is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0001562 name: response to protozoan namespace: biological_process alt_id: GO:0042833 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] synonym: "resistance to pathogenic protozoa" RELATED [] synonym: "response to protozoa" EXACT [] synonym: "response to protozoon" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0001563 name: detection of protozoan namespace: biological_process def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] synonym: "detection of protozoa" EXACT [] synonym: "detection of protozoon" EXACT [] synonym: "perception of protozoa" RELATED [] is_a: GO:0001562 ! response to protozoan is_a: GO:0098543 ! detection of other organism [Term] id: GO:0001564 name: obsolete resistance to pathogenic protozoa namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic protozoa" EXACT [] is_obsolete: true replaced_by: GO:0001562 [Term] id: GO:0001565 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0001566 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570] is_a: GO:0001565 ! phorbol ester receptor activity [Term] id: GO:0001567 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21104] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: KEGG_REACTION:R07218 xref: MetaCyc:1.14.99.38-RXN xref: RHEA:21104 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001571 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0001572 name: lactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501] synonym: "lactosylceramide anabolism" EXACT [] synonym: "lactosylceramide biosynthesis" EXACT [] synonym: "lactosylceramide formation" EXACT [] synonym: "lactosylceramide synthesis" EXACT [] is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046478 ! lactosylceramide metabolic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001573 name: ganglioside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] synonym: "ganglioside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001574 name: ganglioside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] synonym: "ganglioside anabolism" EXACT [] synonym: "ganglioside biosynthesis" EXACT [] synonym: "ganglioside formation" EXACT [] synonym: "ganglioside synthesis" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001575 name: globoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732] synonym: "globoside metabolism" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001576 name: globoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732] synonym: "globoside anabolism" EXACT [] synonym: "globoside biosynthesis" EXACT [] synonym: "globoside formation" EXACT [] synonym: "globoside synthesis" EXACT [] is_a: GO:0001575 ! globoside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001577 name: obsolete galectin namespace: molecular_function def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] comment: This term was made obsolete because it refers to a class of gene products. synonym: "galectin" EXACT [] synonym: "S-type lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0016936 [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001579 name: medium-chain fatty acid transport namespace: biological_process def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0001580 name: detection of chemical stimulus involved in sensory perception of bitter taste namespace: biological_process def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "bitter taste detection" EXACT [] synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of bitter taste" EXACT [] synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] synonym: "sensory transduction of bitter taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050913 ! sensory perception of bitter taste relationship: part_of GO:0050913 ! sensory perception of bitter taste [Term] id: GO:0001581 name: detection of chemical stimulus involved in sensory perception of sour taste namespace: biological_process def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory detection of sour taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory transduction of sour taste" EXACT [] synonym: "sour taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050915 ! sensory perception of sour taste relationship: part_of GO:0050915 ! sensory perception of sour taste [Term] id: GO:0001582 name: detection of chemical stimulus involved in sensory perception of sweet taste namespace: biological_process def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory detection of sweet taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory transduction of sweet taste" EXACT [] synonym: "sweet taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050916 ! sensory perception of sweet taste relationship: part_of GO:0050916 ! sensory perception of sweet taste [Term] id: GO:0001583 name: detection of chemical stimulus involved in sensory perception of salty taste namespace: biological_process def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] synonym: "salty taste detection" EXACT [] synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory detection of salty taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory transduction of salty taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050914 ! sensory perception of salty taste relationship: part_of GO:0050914 ! sensory perception of salty taste [Term] id: GO:0001584 name: obsolete rhodopsin-like receptor activity namespace: molecular_function alt_id: GO:0001620 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] synonym: "rhodopsin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001586 name: Gi/o-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247] synonym: "5-HT1 receptor activity" EXACT [GOC:bf] synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf] is_a: GO:0004993 ! G protein-coupled serotonin receptor activity [Term] id: GO:0001587 name: Gq/11-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043] synonym: "5-HT2 receptor activity" BROAD [GOC:bf] synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf] is_a: GO:0004993 ! G protein-coupled serotonin receptor activity [Term] id: GO:0001588 name: dopamine neurotransmitter receptor activity, coupled via Gs namespace: molecular_function alt_id: GO:0001589 alt_id: GO:0001590 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260] synonym: "dopamine D1 receptor activity" NARROW [GOC:bf] synonym: "dopamine D5 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001591 name: dopamine neurotransmitter receptor activity, coupled via Gi/Go namespace: molecular_function alt_id: GO:0001592 alt_id: GO:0001593 alt_id: GO:0001670 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258] synonym: "dopamine D2 receptor activity" NARROW [GOC:bf] synonym: "dopamine D3 receptor activity" NARROW [GOC:bf] synonym: "dopamine D4 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001594 name: trace-amine receptor activity namespace: molecular_function def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074] is_a: GO:0008227 ! G protein-coupled amine receptor activity [Term] id: GO:0001595 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0038166 ! angiotensin-activated signaling pathway [Term] id: GO:0001596 name: angiotensin type I receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869] synonym: "PLC-activating angiotensin receptor activity" EXACT [GOC:bf] is_a: GO:0001595 ! angiotensin receptor activity relationship: part_of GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway [Term] id: GO:0001597 name: obsolete apelin-like receptor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because the function it represents does not exist. synonym: "apelin-like receptor" EXACT [] synonym: "APJ-like receptor" EXACT [] is_obsolete: true consider: GO:0031704 [Term] id: GO:0001598 name: obsolete chemokine receptor-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "chemokine receptor-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001601 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001602 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001603 name: obsolete vasopressin-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] synonym: "vasopressin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001604 name: urotensin II receptor activity namespace: molecular_function def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001605 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] is_a: GO:0097642 ! calcitonin family receptor activity [Term] id: GO:0001606 name: obsolete GPR37/endothelin B-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "GPR37/endothelin B-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001607 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity relationship: has_part GO:0042924 ! neuromedin U binding [Term] id: GO:0001608 name: G protein-coupled nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001609 name: G protein-coupled adenosine receptor activity namespace: molecular_function alt_id: GO:0001610 alt_id: GO:0001611 alt_id: GO:0001612 alt_id: GO:0001613 alt_id: GO:0008501 def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "P1 receptor" EXACT [PMID:9755289] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0035586 ! purinergic receptor activity relationship: part_of GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "P2 receptor" RELATED [PMID:9755289] is_a: GO:0016502 ! nucleotide receptor activity is_a: GO:0035586 ! purinergic receptor activity relationship: has_part GO:0017076 ! purine nucleotide binding relationship: part_of GO:0035590 ! purinergic nucleotide receptor signaling pathway [Term] id: GO:0001615 name: obsolete thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "thyrotropin releasing hormone and secretagogue-like receptors activity" EXACT [] is_obsolete: true [Term] id: GO:0001616 name: growth hormone secretagogue receptor activity namespace: molecular_function def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853] synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001617 name: obsolete growth hormone secretagogue-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "growth hormone secretagogue-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001618 name: virus receptor activity namespace: molecular_function def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] subset: goslim_chembl synonym: "viral receptor activity" EXACT [] is_a: GO:0140272 ! exogenous protein binding relationship: part_of GO:0046718 ! viral entry into host cell [Term] id: GO:0001619 name: obsolete lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] synonym: "lysosphingolipid and lysophosphatidic acid receptor activity" EXACT [] is_obsolete: true consider: GO:0038036 consider: GO:0070915 [Term] id: GO:0001621 name: ADP receptor activity namespace: molecular_function def: "Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:11196645] synonym: "K101 receptor" NARROW [] synonym: "platelet ADP receptor activity" NARROW [GOC:mah] is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity relationship: has_part GO:0043531 ! ADP binding [Term] id: GO:0001626 name: nociceptin receptor activity namespace: molecular_function def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432] synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "OFQ receptor activity" EXACT [PR:000012940] synonym: "ORPH receptor" EXACT [] synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "X-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0001627 name: obsolete leucine-rich G-protein receptor-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "leucine-rich G-protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001628 name: obsolete gastropyloric receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the gastropyloric receptor is a type of neuron. synonym: "gastropyloric receptor activity" EXACT [] synonym: "GPR receptor" EXACT [] is_obsolete: true [Term] id: GO:0001629 name: obsolete G-protein receptor 45-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "G-protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001630 name: obsolete GP40-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "GP40-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001631 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] synonym: "CysLT receptor" EXACT [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001632 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732] synonym: "BLT receptor" NARROW [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001633 name: obsolete secretin-like receptor activity namespace: molecular_function alt_id: GO:0001638 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] synonym: "secretin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001634 name: pituitary adenylate cyclase-activating polypeptide receptor activity namespace: molecular_function alt_id: GO:0016522 def: "A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001635 name: calcitonin gene-related peptide receptor activity namespace: molecular_function def: "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity." [GOC:mah, PMID:12037140] synonym: "calcitonin gene-related polypeptide receptor activity" EXACT [] synonym: "CGRP receptor" EXACT [] xref: Wikipedia:CALCRL is_a: GO:0097642 ! calcitonin family receptor activity [Term] id: GO:0001636 name: obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001637 name: G protein-coupled chemoattractant receptor activity namespace: molecular_function def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah] synonym: "G protein chemoattractant receptor activity" EXACT [] synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf] synonym: "G-protein coupled chemoattractant receptor activity" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001639 name: PLC activating G protein-coupled glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] synonym: "PLC activating G-protein coupled glutamate receptor activity" EXACT [] synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf] is_a: GO:0098988 ! G protein-coupled glutamate receptor activity relationship: part_of GO:0007206 ! phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0001640 name: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph] synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] is_a: GO:0098988 ! G protein-coupled glutamate receptor activity relationship: part_of GO:0007196 ! adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0001641 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [Term] id: GO:0001642 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [Term] id: GO:0001646 name: cAMP receptor activity namespace: molecular_function alt_id: GO:0001644 def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] is_a: GO:0001614 ! purinergic nucleotide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity relationship: has_part GO:0030552 ! cAMP binding [Term] id: GO:0001647 name: G protein-coupled cytokinin receptor activity namespace: molecular_function def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein coupled cytokinin receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0001648 name: proteinase activated receptor activity namespace: molecular_function def: "A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001650 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0001651 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412] xref: NIF_Subcellular:sao1841764412 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0001652 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903] xref: NIF_Subcellular:sao1217793903 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0042277 ! peptide binding [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: MIPS_funcat:47.03.02.02 xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0150063 ! visual system development [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0072164 ! mesonephric tubule development [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: part_of GO:0060675 ! ureteric bud morphogenesis relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:36.09 xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001660 name: fever generation namespace: biological_process def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl] synonym: "pyrexia" BROAD [] xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001662 name: behavioral fear response namespace: biological_process def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] synonym: "behavioural fear response" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0042596 ! fear response [Term] id: GO:0001664 name: G protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein coupled receptor binding" EXACT [GOC:bf] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer" is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0001665 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN xref: Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)" xref: Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] synonym: "acrosomal granule" EXACT [GOC:sart] synonym: "acrosome" EXACT [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0001671 name: ATPase activator activity namespace: molecular_function def: "Binds to and increases the ATP hydrolysis activity of an ATPase." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] xref: Reactome:R-HSA-5251955 "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm" xref: Reactome:R-HSA-5251959 "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0060590 ! ATPase regulator activity relationship: part_of GO:0032781 ! positive regulation of ATPase activity relationship: positively_regulates GO:0016887 ! ATPase activity [Term] id: GO:0001672 name: regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006333 ! chromatin assembly or disassembly relationship: regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component alt_id: GO:0043081 def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033363 ! secretory granule organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ajp] synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0001680 name: tRNA 3'-terminal CCA addition namespace: biological_process def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators] synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72] synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA-adding enzyme activity" EXACT [EC:2.7.7.72] synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72] synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72] xref: KEGG_REACTION:R09382 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0042780 ! tRNA 3'-end processing relationship: has_part GO:0052927 ! CTP:tRNA cytidylyltransferase activity relationship: has_part GO:0052928 ! CTP:3'-cytidine-tRNA cytidylyltransferase activity relationship: has_part GO:0052929 ! ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [Term] id: GO:0001681 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0001682 name: tRNA 5'-leader removal namespace: biological_process def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] synonym: "tRNA 5' leader removal" EXACT [] is_a: GO:0099116 ! tRNA 5'-end processing [Term] id: GO:0001683 name: obsolete axonemal dynein heavy chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein heavy chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001684 name: obsolete axonemal dynein intermediate chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein intermediate chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001685 name: obsolete axonemal dynein intermediate light chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein intermediate light chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001686 name: obsolete axonemal dynein light chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein light chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001687 name: obsolete cytoplasmic dynein heavy chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein heavy chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001688 name: obsolete cytoplasmic dynein intermediate chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein intermediate chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001689 name: obsolete cytoplasmic dynein intermediate light chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein intermediate light chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001690 name: obsolete cytoplasmic dynein light chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein light chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001691 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] is_a: GO:0019212 ! phosphatase inhibitor activity [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process alt_id: GO:0001693 def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001697 name: histamine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001698 name: gastrin-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion relationship: has_part GO:0015054 ! gastrin receptor activity [Term] id: GO:0001699 name: acetylcholine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion relationship: has_part GO:0015464 ! acetylcholine receptor activity relationship: part_of GO:1905145 ! cellular response to acetylcholine [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process alt_id: GO:0010003 alt_id: GO:0048276 def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" NARROW [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001708 name: cell fate specification namespace: biological_process def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001709 name: cell fate determination namespace: biological_process def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] xref: Wikipedia:Cell_fate_determination is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001710 name: mesodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] synonym: "mesoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0048333 ! mesodermal cell differentiation [Term] id: GO:0001711 name: endodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] synonym: "endoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0035987 ! endodermal cell differentiation [Term] id: GO:0001712 name: ectodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0001705 ! ectoderm formation relationship: part_of GO:0010668 ! ectodermal cell differentiation [Term] id: GO:0001713 name: ectodermal cell fate determination namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001714 name: endodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "endoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0001715 name: ectodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "ectoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001716 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2] synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN xref: Reactome:R-HSA-2160492 "IL4I1:FAD oxidises L-Phe to kPPV" xref: RHEA:13781 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0001717 name: conversion of seryl-tRNAsec to selenocys-tRNAsec namespace: biological_process def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X] is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001720 name: conversion of lysyl-tRNA to pyrrolysyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001721 name: obsolete intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "IFAP" EXACT [] synonym: "intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001722 name: obsolete type I intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type I intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001723 name: obsolete type II intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type II intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001724 name: obsolete type III intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type III intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0001725 name: stress fiber namespace: cellular_component def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] synonym: "actin cable" RELATED [GOC:mah] synonym: "stress fibre" EXACT [] is_a: GO:0042641 ! actomyosin is_a: GO:0097517 ! contractile actin filament bundle [Term] id: GO:0001726 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0001727 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046834 ! lipid phosphorylation [Term] id: GO:0001729 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: MetaCyc:CERAMIDE-KINASE-RXN xref: Reactome:R-HSA-1638845 "CERK phosphorylates CERA to form C1P" xref: RHEA:17929 is_a: GO:0001727 ! lipid kinase activity [Term] id: GO:0001730 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732] synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] xref: EC:2.7.7.84 xref: MetaCyc:RXN-10798 xref: MetaCyc:RXN-13648 xref: Reactome:R-HSA-8983680 "OAS1 produces oligoadenylates" xref: Reactome:R-HSA-8985091 "OAS3 produces oligoadenylates" xref: Reactome:R-HSA-8985104 "OAS2 produces oligoadenylates" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0001731 name: formation of translation preinitiation complex namespace: biological_process def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. synonym: "formation of translation pre-initiation complex" EXACT [] synonym: "translation preinitiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0001732 name: formation of cytoplasmic translation initiation complex namespace: biological_process def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] synonym: "cytoplasmic translation initiation complex assembly" EXACT [] synonym: "formation of translation initiation complex" BROAD [] synonym: "translation initiation complex assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0001733 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN xref: RHEA:20613 is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity [Term] id: GO:0001734 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd] xref: Reactome:R-HSA-72095 "Internal Methylation of mRNA" is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0001735 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: MetaCyc:1.8.3.5-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001737 name: establishment of imaginal disc-derived wing hair orientation namespace: biological_process def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] synonym: "establishment of wing hair orientation" EXACT [] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732] is_a: GO:0005720 ! nuclear heterochromatin intersection_of: GO:0005720 ! nuclear heterochromatin intersection_of: part_of GO:0000803 ! sex chromosome relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0001740 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684] xref: NIF_Subcellular:sao1571698684 xref: Wikipedia:Barr_body is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000805 ! X chromosome relationship: has_part GO:0098578 ! condensed chromatin of inactivated sex chromosome [Term] id: GO:0001741 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] is_a: GO:0000803 ! sex chromosome relationship: has_part GO:0098578 ! condensed chromatin of inactivated sex chromosome [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001743 name: optic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048598 ! embryonic morphogenesis [Term] id: GO:0001744 name: optic lobe placode formation namespace: biological_process alt_id: GO:0007457 def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] is_a: GO:0060788 ! ectodermal placode formation [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0001746 name: Bolwig's organ morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0055034 ! Bolwig's organ development [Term] id: GO:0001748 name: optic lobe placode development namespace: biological_process alt_id: GO:0048049 def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] synonym: "optic placode development" BROAD [] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0001750 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins." [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097733 ! photoreceptor cell cilium [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0001752 name: compound eye photoreceptor fate commitment namespace: biological_process alt_id: GO:0007459 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0001753 name: obsolete adult eye photoreceptor development (sensu Drosophila) namespace: biological_process def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. synonym: "adult eye photoreceptor development (sensu Drosophila)" EXACT [] is_obsolete: true consider: GO:0042051 [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0014032 ! neural crest cell development [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001757 name: somite specification namespace: biological_process def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph] is_a: GO:0007379 ! segment specification is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0001758 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN xref: Reactome:R-HSA-5362522 "ALDHs oxidise atRAL to atRA" xref: Reactome:R-HSA-5696101 "ALDH8A1 oxidises 9cRAL to 9cRA" xref: RHEA:16177 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0001759 name: organ induction namespace: biological_process def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] synonym: "induction of an organ" EXACT [] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:0031128 ! developmental induction is_a: GO:0110110 ! positive regulation of animal organ morphogenesis relationship: positively_regulates GO:0010092 ! specification of animal organ identity [Term] id: GO:0001760 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16557] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "ACMSD activity" EXACT [PMID:17288562] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: KEGG_REACTION:R04323 xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN xref: RHEA:16557 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0001761 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:0001762 ! beta-alanine transport [Term] id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] synonym: "neuron chemotaxis" EXACT [] synonym: "neuron guidance" RELATED [] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0001765 name: membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] synonym: "lipid raft assembly" EXACT [GOC:mah] synonym: "lipid raft formation" RELATED [] synonym: "membrane raft formation" RELATED [GOC:mah] is_a: GO:0031579 ! membrane raft organization is_a: GO:0071709 ! membrane assembly [Term] id: GO:0001766 name: membrane raft polarization namespace: biological_process def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] synonym: "lipid raft polarization" EXACT [] is_a: GO:0031580 ! membrane raft distribution [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042110 ! T cell activation [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042113 ! B cell activation [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0030101 ! natural killer cell activation [Term] id: GO:0001771 name: immunological synapse formation namespace: biological_process def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] synonym: "formation of immunological synapse" EXACT [] is_a: GO:0009988 ! cell-cell recognition relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001772 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: Wikipedia:Immunological_synapse is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0002269 ! leukocyte activation involved in inflammatory response is_a: GO:0042116 ! macrophage activation is_a: GO:0061900 ! glial cell activation [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0001778 name: plasma membrane repair namespace: biological_process def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development" RELATED [GOC:add] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0001781 name: neutrophil apoptotic process namespace: biological_process def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil apoptosis" NARROW [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process relationship: part_of GO:0001780 ! neutrophil homeostasis [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0001783 name: B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell apoptosis" NARROW [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0001784 name: phosphotyrosine residue binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584] synonym: "phosphotyrosine binding" RELATED [] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0001785 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0001786 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961] is_a: GO:0005543 ! phospholipid binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0001788 name: antibody-dependent cellular cytotoxicity namespace: biological_process def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795] synonym: "ADCC" EXACT [] synonym: "antibody dependent cell death" EXACT [] synonym: "antibody dependent cell killing" EXACT [] synonym: "antibody-dependent cell death" EXACT [] synonym: "antibody-dependent cell killing" EXACT [] synonym: "type VI hypersensitivity" EXACT [] xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity is_a: GO:0001794 ! type IIa hypersensitivity is_a: GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001790 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001791 name: IgM binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001792 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity relationship: has_part GO:0001790 ! polymeric immunoglobulin binding [Term] id: GO:0001793 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity relationship: has_part GO:0001791 ! IgM binding [Term] id: GO:0001794 name: type IIa hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149] comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001795 name: type IIb hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. synonym: "type V hypersensitivity" EXACT [] is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001796 name: regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001794 ! type IIa hypersensitivity relationship: regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001797 name: negative regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIa hypersensitivity" EXACT [] synonym: "down-regulation of type IIa hypersensitivity" EXACT [] synonym: "downregulation of type IIa hypersensitivity" EXACT [] synonym: "inhibition of type IIa hypersensitivity" NARROW [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001794 ! type IIa hypersensitivity relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001798 name: positive regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIa hypersensitivity" NARROW [] synonym: "stimulation of type IIa hypersensitivity" NARROW [] synonym: "up regulation of type IIa hypersensitivity" EXACT [] synonym: "up-regulation of type IIa hypersensitivity" EXACT [] synonym: "upregulation of type IIa hypersensitivity" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001794 ! type IIa hypersensitivity relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001799 name: regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001795 ! type IIb hypersensitivity relationship: regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001800 name: negative regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIb hypersensitivity" EXACT [] synonym: "down-regulation of type IIb hypersensitivity" EXACT [] synonym: "downregulation of type IIb hypersensitivity" EXACT [] synonym: "inhibition of type IIb hypersensitivity" NARROW [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001795 ! type IIb hypersensitivity relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001801 name: positive regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIb hypersensitivity" NARROW [] synonym: "stimulation of type IIb hypersensitivity" NARROW [] synonym: "up regulation of type IIb hypersensitivity" EXACT [] synonym: "up-regulation of type IIb hypersensitivity" EXACT [] synonym: "upregulation of type IIb hypersensitivity" EXACT [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001795 ! type IIb hypersensitivity relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001802 name: type III hypersensitivity namespace: biological_process def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149] comment: Note that the Arthus reaction is an example of type III hypersensitivity. xref: Wikipedia:Type_III_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0001803 name: regulation of type III hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001802 ! type III hypersensitivity relationship: regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001804 name: negative regulation of type III hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type III hypersensitivity" EXACT [] synonym: "down-regulation of type III hypersensitivity" EXACT [] synonym: "downregulation of type III hypersensitivity" EXACT [] synonym: "inhibition of type III hypersensitivity" NARROW [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001802 ! type III hypersensitivity relationship: negatively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001805 name: positive regulation of type III hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type III hypersensitivity" NARROW [] synonym: "stimulation of type III hypersensitivity" NARROW [] synonym: "up regulation of type III hypersensitivity" EXACT [] synonym: "up-regulation of type III hypersensitivity" EXACT [] synonym: "upregulation of type III hypersensitivity" EXACT [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001802 ! type III hypersensitivity relationship: positively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001806 name: type IV hypersensitivity namespace: biological_process alt_id: GO:0016069 def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149] synonym: "delayed hypersensitivity response" EXACT [] synonym: "delayed-type hypersensitivity" EXACT [] xref: Wikipedia:Type_IV_hypersensitivity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002524 ! hypersensitivity [Term] id: GO:0001807 name: regulation of type IV hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001806 ! type IV hypersensitivity relationship: regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001808 name: negative regulation of type IV hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IV hypersensitivity" EXACT [] synonym: "down-regulation of type IV hypersensitivity" EXACT [] synonym: "downregulation of type IV hypersensitivity" EXACT [] synonym: "inhibition of type IV hypersensitivity" NARROW [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002884 ! negative regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001806 ! type IV hypersensitivity relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001809 name: positive regulation of type IV hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IV hypersensitivity" NARROW [] synonym: "stimulation of type IV hypersensitivity" NARROW [] synonym: "up regulation of type IV hypersensitivity" EXACT [] synonym: "up-regulation of type IV hypersensitivity" EXACT [] synonym: "upregulation of type IV hypersensitivity" EXACT [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002885 ! positive regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001806 ! type IV hypersensitivity relationship: positively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001810 name: regulation of type I hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016068 ! type I hypersensitivity relationship: regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001811 name: negative regulation of type I hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type I hypersensitivity" EXACT [] synonym: "down-regulation of type I hypersensitivity" EXACT [] synonym: "downregulation of type I hypersensitivity" EXACT [] synonym: "inhibition of type I hypersensitivity" NARROW [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016068 ! type I hypersensitivity relationship: negatively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001812 name: positive regulation of type I hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type I hypersensitivity" NARROW [] synonym: "stimulation of type I hypersensitivity" NARROW [] synonym: "up regulation of type I hypersensitivity" EXACT [] synonym: "up-regulation of type I hypersensitivity" EXACT [] synonym: "upregulation of type I hypersensitivity" EXACT [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016068 ! type I hypersensitivity relationship: positively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001813 name: regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of antibody dependent cell death" EXACT [] synonym: "regulation of antibody dependent cell killing" EXACT [] synonym: "regulation of antibody-dependent cell death" EXACT [] synonym: "regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001814 name: negative regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "negative regulation of antibody dependent cell death" EXACT [] synonym: "negative regulation of antibody dependent cell killing" EXACT [] synonym: "negative regulation of antibody-dependent cell death" EXACT [] synonym: "negative regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001815 name: positive regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "positive regulation of antibody dependent cell death" EXACT [] synonym: "positive regulation of antibody dependent cell killing" EXACT [] synonym: "positive regulation of antibody-dependent cell death" EXACT [] synonym: "positive regulation of antibody-dependent cell killing" EXACT [] synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. subset: goslim_pir synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001816 ! cytokine production relationship: regulates GO:0001816 ! cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine production" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001816 ! cytokine production relationship: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001816 ! cytokine production relationship: positively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] synonym: "nephrogenesis" RELATED [GOC:rph] xref: MIPS_funcat:47.03.07.01 xref: Wikipedia:Kidney_development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] synonym: "Wolffian body development" EXACT [GOC:dph] is_a: GO:0001822 ! kidney development [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. xref: MIPS_funcat:41.05.03.03 is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001701 ! in utero embryonic development [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. xref: MIPS_funcat:41.05.03.03.03 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001827 name: inner cell mass cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001828 name: inner cell mass cellular morphogenesis namespace: biological_process def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] xref: MIPS_funcat:41.05.03.03.01 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001830 name: trophectodermal cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell fate commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001835 name: blastocyst hatching namespace: biological_process def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. is_a: GO:0035188 ! hatching relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001836 name: release of cytochrome c from mitochondria namespace: biological_process def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011. is_a: GO:0008637 ! apoptotic mitochondrial changes relationship: part_of GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] is_a: GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001844 name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway namespace: biological_process def: "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892] comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb] synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [] is_a: GO:0051204 ! protein insertion into mitochondrial membrane intersection_of: GO:0051204 ! protein insertion into mitochondrial membrane intersection_of: part_of GO:0097190 ! apoptotic signaling pathway relationship: part_of GO:0097345 ! mitochondrial outer membrane permeabilization [Term] id: GO:0001845 name: phagolysosome assembly namespace: biological_process def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149] synonym: "late phagosome biosynthesis" RELATED [] synonym: "late phagosome formation" RELATED [] synonym: "phagolysosome formation" RELATED [GOC:mah] is_a: GO:0007040 ! lysosome organization is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0090382 ! phagosome maturation [Term] id: GO:0001846 name: opsonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. is_a: GO:0005515 ! protein binding [Term] id: GO:0001847 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0001846 ! opsonin binding [Term] id: GO:0001848 name: complement binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0005515 ! protein binding [Term] id: GO:0001849 name: complement component C1q complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C1q complex, a component of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001850 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001851 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001852 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001853 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001854 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001855 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001856 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001857 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001849 ! complement component C1q complex binding [Term] id: GO:0001858 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001852 ! complement component iC3b binding [Term] id: GO:0001859 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001853 ! complement component C3dg binding [Term] id: GO:0001860 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001854 ! complement component C3d binding [Term] id: GO:0001861 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001855 ! complement component C4b binding [Term] id: GO:0001862 name: collectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001863 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001847 ! opsonin receptor activity relationship: has_part GO:0001862 ! collectin binding [Term] id: GO:0001864 name: pentraxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T cell development" RELATED [GOC:add] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0001867 name: complement activation, lectin pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. synonym: "complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0001868 name: regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149] synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001867 ! complement activation, lectin pathway relationship: regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001869 name: negative regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "down regulation of complement activation, lectin pathway" EXACT [] synonym: "down-regulation of complement activation, lectin pathway" EXACT [] synonym: "downregulation of complement activation, lectin pathway" EXACT [] synonym: "inhibition of complement activation, lectin pathway" NARROW [] synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001867 ! complement activation, lectin pathway relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001870 name: positive regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "activation of complement activation, lectin pathway" NARROW [] synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, lectin pathway" NARROW [] synonym: "up regulation of complement activation, lectin pathway" EXACT [] synonym: "up-regulation of complement activation, lectin pathway" EXACT [] synonym: "upregulation of complement activation, lectin pathway" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001867 ! complement activation, lectin pathway relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001871 name: obsolete pattern binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: This term was obsoleted because it was an unnecessary grouping term. synonym: "pattern recognition activity" BROAD [] is_obsolete: true [Term] id: GO:0001872 name: (1->3)-beta-D-glucan binding namespace: molecular_function alt_id: GO:0080087 def: "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] synonym: "1,3-beta-D-glucan binding" EXACT [] synonym: "callose binding" NARROW [] synonym: "zymosan binding" NARROW [GOC:tb] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001873 name: polysaccharide immune receptor activity namespace: molecular_function def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091] synonym: "polysaccharide receptor activity" BROAD [] is_a: GO:0038187 ! pattern recognition receptor activity relationship: has_part GO:0030247 ! polysaccharide binding [Term] id: GO:0001874 name: (1->3)-beta-D-glucan immune receptor activity namespace: molecular_function def: "Combining with (1->3)-beta-D-glucans to initiate an innate immune response." [PMID:14707091] synonym: "(1,3)-beta-D-glucan receptor activity" EXACT [] synonym: "(1->3)-beta-D-glucan receptor activity" BROAD [] synonym: "1,3-beta-D-glucan receptor activity" EXACT [] synonym: "beta-1,3-D-glucan receptor activity" EXACT [] synonym: "zymosan receptor activity" NARROW [GOC:tb] is_a: GO:0001873 ! polysaccharide immune receptor activity relationship: has_part GO:0001872 ! (1->3)-beta-D-glucan binding [Term] id: GO:0001875 name: lipopolysaccharide immune receptor activity namespace: molecular_function def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] synonym: "endotoxin receptor activity" BROAD [] synonym: "lipopolysaccharide receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] is_a: GO:0038187 ! pattern recognition receptor activity relationship: has_part GO:0001530 ! lipopolysaccharide binding relationship: part_of GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0001876 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] is_a: GO:0034235 ! GPI anchor binding [Term] id: GO:0001877 name: lipoarabinomannan immune receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] synonym: "lipoarabinomannan receptor activity" BROAD [] is_a: GO:0038187 ! pattern recognition receptor activity relationship: has_part GO:0001876 ! lipoarabinomannan binding [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. is_a: GO:0009620 ! response to fungus [Term] id: GO:0001879 name: detection of yeast namespace: biological_process def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] is_a: GO:0001878 ! response to yeast is_a: GO:0016046 ! detection of fungus [Term] id: GO:0001880 name: Mullerian duct regression namespace: biological_process def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0001881 name: receptor recycling namespace: biological_process def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] is_a: GO:0043112 ! receptor metabolic process relationship: has_part GO:0006897 ! endocytosis [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001884 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0001885 ! endothelial cell development [Term] id: GO:0001887 name: selenium compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456] synonym: "selenium compound metabolism" EXACT [] synonym: "selenium metabolic process" EXACT [] synonym: "selenium metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0001888 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] xref: MIPS_funcat:47.03.11.07 is_a: GO:0048732 ! gland development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:47.03.15.05 is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0001891 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048568 ! embryonic organ development relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development is_a: GO:0060135 ! maternal process involved in female pregnancy relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001895 name: retina homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation." [GOC:add, GOC:jh2, GOC:mtg_apoptosis, PMID:10974124, PMID:19286987, PMID:26811896] xref: Wikipedia:Autolysis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0001897 name: cytolysis by symbiont of host cells namespace: biological_process def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] synonym: "cytolysis by organism of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction relationship: has_part GO:0052025 ! modification by symbiont of host cell membrane [Term] id: GO:0001898 name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001899 name: negative regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001900 name: positive regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "activation by symbiont of cytolysis of host cells" NARROW [] synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001905 name: activation of membrane attack complex namespace: biological_process def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149] synonym: "activation of MAC" EXACT [] synonym: "activation of TCC" NARROW [] synonym: "activation of terminal complement complex" NARROW [GOC:add] synonym: "activation of the terminal complement cascade" NARROW [] synonym: "MAC assembly" EXACT [GOC:rl] synonym: "MAC formation" EXACT [GOC:rl] synonym: "membrane attack complex assembly" EXACT [GOC:rl] synonym: "membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0006956 ! complement activation [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0044004 ! disruption by symbiont of host cell is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826] comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] xref: MIPS_funcat:36.25.16.01.05 is_a: GO:0001906 ! cell killing [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0031341 ! regulation of cell killing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0031342 ! negative regulation of cell killing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0031343 ! positive regulation of cell killing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001913 ! T cell mediated cytotoxicity relationship: regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001913 ! T cell mediated cytotoxicity relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001917 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0001918 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765] is_a: GO:0005515 ! protein binding [Term] id: GO:0001919 name: regulation of receptor recycling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] is_a: GO:0023051 ! regulation of signaling is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001881 ! receptor recycling relationship: regulates GO:0001881 ! receptor recycling [Term] id: GO:0001920 name: negative regulation of receptor recycling namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] synonym: "down regulation of receptor recycling" EXACT [] synonym: "down-regulation of receptor recycling" EXACT [] synonym: "downregulation of receptor recycling" EXACT [] synonym: "inhibition of receptor recycling" NARROW [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031324 ! negative regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001881 ! receptor recycling relationship: negatively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001921 name: positive regulation of receptor recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] synonym: "activation of receptor recycling" NARROW [] synonym: "stimulation of receptor recycling" NARROW [] synonym: "up regulation of receptor recycling" EXACT [] synonym: "up-regulation of receptor recycling" EXACT [] synonym: "upregulation of receptor recycling" EXACT [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031325 ! positive regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001881 ! receptor recycling relationship: positively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] synonym: "B-1 B cell development" RELATED [GOC:add] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B-1 B cell development" RELATED [GOC:add] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001923 ! B-1 B cell differentiation relationship: regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001923 ! B-1 B cell differentiation relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001923 ! B-1 B cell differentiation relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001927 name: exocyst assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0140029 ! exocytic process relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis [Term] id: GO:0001928 name: regulation of exocyst assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0106020 ! regulation of vesicle docking intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001927 ! exocyst assembly relationship: regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001929 name: negative regulation of exocyst assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd] synonym: "down regulation of exocyst assembly" EXACT [] synonym: "down-regulation of exocyst assembly" EXACT [] synonym: "downregulation of exocyst assembly" EXACT [] synonym: "inhibition of exocyst assembly" NARROW [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:0106021 ! negative regulation of vesicle docking intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001927 ! exocyst assembly relationship: negatively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001930 name: positive regulation of exocyst assembly namespace: biological_process def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] synonym: "activation of exocyst assembly" NARROW [] synonym: "stimulation of exocyst assembly" NARROW [] synonym: "up regulation of exocyst assembly" EXACT [] synonym: "up-regulation of exocyst assembly" EXACT [] synonym: "upregulation of exocyst assembly" EXACT [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:0106022 ! positive regulation of vesicle docking intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001927 ! exocyst assembly relationship: positively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001931 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: part_of GO:0031254 ! cell trailing edge relationship: part_of GO:0031254 ! cell trailing edge [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006468 ! protein phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006468 ! protein phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001935 ! endothelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001939 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr] synonym: "post-synaptic membrane organization" EXACT [] synonym: "postsynaptic membrane organisation" EXACT [] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0099173 ! postsynapse organization [Term] id: GO:0001942 name: hair follicle development namespace: biological_process alt_id: GO:0001943 def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] xref: MIPS_funcat:47.03.13.05 is_a: GO:0022405 ! hair cycle process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0098773 ! skin epidermis development [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] xref: MIPS_funcat:45.03.05.09 xref: MIPS_funcat:47.03.03.02 is_a: GO:0048731 ! system development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] xref: MIPS_funcat:47.03.05.03 is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0036303 ! lymph vessel morphogenesis [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0001950 name: obsolete plasma membrane enriched fraction namespace: cellular_component def: "OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "plasma membrane enriched fraction" EXACT [] synonym: "PME fraction" RELATED [GOC:mah] is_obsolete: true consider: GO:0005886 [Term] id: GO:0001951 name: intestinal D-glucose absorption namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0106001 ! intestinal hexose absorption [Term] id: GO:0001952 name: regulation of cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] is_a: GO:0010810 ! regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007160 ! cell-matrix adhesion relationship: regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001953 name: negative regulation of cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] synonym: "down regulation of cell-matrix adhesion" EXACT [] synonym: "down-regulation of cell-matrix adhesion" EXACT [] synonym: "downregulation of cell-matrix adhesion" EXACT [] synonym: "inhibition of cell-matrix adhesion" NARROW [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010812 ! negative regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007160 ! cell-matrix adhesion relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001954 name: positive regulation of cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] synonym: "activation of cell-matrix adhesion" NARROW [] synonym: "stimulation of cell-matrix adhesion" NARROW [] synonym: "up regulation of cell-matrix adhesion" EXACT [] synonym: "up-regulation of cell-matrix adhesion" EXACT [] synonym: "upregulation of cell-matrix adhesion" EXACT [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010811 ! positive regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007160 ! cell-matrix adhesion relationship: positively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0036075 ! replacement ossification relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001962 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0001964 name: startle response namespace: biological_process def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] xref: Wikipedia:Startle_reaction is_a: GO:0009605 ! response to external stimulus is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0001965 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0001966 name: thigmotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] synonym: "stereotaxis" EXACT [] synonym: "taxis in response to mechanical stimulus" BROAD [] synonym: "taxis in response to touch stimulus" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0001967 name: suckling behavior namespace: biological_process def: "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr] synonym: "nursing behavior" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0001969 name: regulation of activation of membrane attack complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "regulation of activation of MAC" EXACT [GOC:mah] synonym: "regulation of activation of TCC" NARROW [GOC:mah] synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "regulation of MAC assembly" EXACT [GOC:rl] synonym: "regulation of MAC formation" EXACT [GOC:rl] synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0030449 ! regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001905 ! activation of membrane attack complex relationship: regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001970 name: positive regulation of activation of membrane attack complex namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "activation of activation of membrane attack complex" NARROW [] synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] synonym: "positive regulation of MAC formation" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] synonym: "stimulation of activation of membrane attack complex" NARROW [] synonym: "up regulation of activation of membrane attack complex" EXACT [] synonym: "up-regulation of activation of membrane attack complex" EXACT [] synonym: "upregulation of activation of membrane attack complex" EXACT [] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001905 ! activation of membrane attack complex relationship: positively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001971 name: negative regulation of activation of membrane attack complex namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "down regulation of activation of membrane attack complex" EXACT [] synonym: "down-regulation of activation of membrane attack complex" EXACT [] synonym: "downregulation of activation of membrane attack complex" EXACT [] synonym: "inhibition of activation of membrane attack complex" NARROW [] synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] synonym: "negative regulation of MAC formation" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001905 ! activation of membrane attack complex relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001972 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] is_a: GO:0005501 ! retinoid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0001973 name: adenosine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph] synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289] synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0001975 name: response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:dph, GOC:ef] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0009636 ! response to toxic substance is_a: GO:0014075 ! response to amine is_a: GO:0097366 ! response to bronchodilator [Term] id: GO:0001976 name: nervous system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels [Term] id: GO:0001978 name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "baroreceptor feedback control of blood pressure" RELATED [] synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X] synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0001979 name: regulation of systemic arterial blood pressure by chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "chemoreceptor control of blood pressure" RELATED [] synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001980 name: regulation of systemic arterial blood pressure by ischemic conditions namespace: biological_process def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "CNS ischemic response" RELATED [ISBN:0721643949] synonym: "ischemic control of blood pressure" RELATED [] synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001981 name: baroreceptor detection of arterial stretch namespace: biological_process def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0001982 name: baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0001983 name: baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0001984 name: artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure" EXACT [] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001985 name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949] synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0010459 ! negative regulation of heart rate intersection_of: GO:0010459 ! negative regulation of heart rate intersection_of: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001986 name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0045822 ! negative regulation of heart contraction relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001987 name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001988 name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate intersection_of: GO:0010460 ! positive regulation of heart rate intersection_of: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001989 name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0001993 name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949] synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0001994 name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001995 name: norepinephrine-epinephrine catabolic process in blood stream namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] is_a: GO:0042419 ! epinephrine catabolic process relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0001996 name: positive regulation of heart rate by epinephrine-norepinephrine namespace: biological_process def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001997 name: positive regulation of the force of heart contraction by epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] synonym: "increased inotropy by epinephrine-norepinephrine" RELATED [] synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001998 name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, GOC:pr, ISBN:0721643949] synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] synonym: "angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0002034 ! regulation of blood vessel diameter by renin-angiotensin [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002000 name: detection of renal blood flow namespace: biological_process def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949] is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002002 name: regulation of angiotensin levels in blood namespace: biological_process def: "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation." [GOC:rl, PMID:21951628, Wikipedia:Angiotensin] comment: Updated definition as discussed inhttps://github.com/geneontology/go-ontology/issues/15424 synonym: "control of angiotensin levels in blood" RELATED [] synonym: "control of blood angiotensin level" RELATED [] synonym: "regulation of blood angiotensin level" EXACT [] is_a: GO:0010817 ! regulation of hormone levels relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002003 name: angiotensin maturation namespace: biological_process alt_id: GO:0002005 def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood." [ISBN:0721643949] synonym: "angiotensin catabolic process in blood" NARROW [] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002004 name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure namespace: biological_process def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949] synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0030103 ! vasopressin secretion relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002006 name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002007 name: detection of hypoxic conditions in blood by chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus relationship: has_part GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0002008 name: excitation of vasomotor center by chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] xref: MIPS_funcat:45.03.09 is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002010 name: excitation of vasomotor center by baroreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002012 name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002013 name: detection of carbon dioxide by vasomotor center namespace: biological_process def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002014 name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure namespace: biological_process def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002015 name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback namespace: biological_process def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "atrial control of blood pressure" RELATED [] synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] synonym: "atrial reflex" RELATED [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0002016 name: regulation of blood volume by renin-angiotensin namespace: biological_process def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "renin-angiotensin control of body fluid levels" RELATED [] synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0002017 name: regulation of blood volume by renal aldosterone namespace: biological_process def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "aldosterone mediated control of body fluids" RELATED [] synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002018 name: renin-angiotensin regulation of aldosterone production namespace: biological_process def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949] synonym: "renin-angiotensin control of aldosterone production" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure is_a: GO:2000858 ! regulation of aldosterone secretion intersection_of: GO:0003014 ! renal system process intersection_of: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin intersection_of: regulates GO:0035932 ! aldosterone secretion relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002019 name: regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "angiotensin mediated control of renal output" RELATED [] synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002020 name: protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd] xref: Reactome:R-HSA-1297354 "Acrosin Cleavage" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0002021 name: response to dietary excess namespace: biological_process def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0002022 name: detection of dietary excess namespace: biological_process def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655] is_a: GO:0050877 ! nervous system process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002023 name: reduction of food intake in response to dietary excess namespace: biological_process def: "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200] is_a: GO:0042755 ! eating behavior relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002024 name: diet induced thermogenesis namespace: biological_process def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] is_a: GO:1990845 ! adaptive thermogenesis relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002025 name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] synonym: "vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0002026 name: regulation of the force of heart contraction namespace: biological_process def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] synonym: "heart inotropy" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006814 ! sodium ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002029 name: desensitization of G protein-coupled receptor signaling pathway namespace: biological_process def: "The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway." [PMID:8396717] synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0022401 ! negative adaptation of signaling pathway is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway [Term] id: GO:0002030 name: inhibitory G protein-coupled receptor phosphorylation namespace: biological_process def: "The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] synonym: "inhibitory G-protein coupled receptor phosphorylation" EXACT [] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway [Term] id: GO:0002031 name: G protein-coupled receptor internalization namespace: biological_process def: "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle." [PMID:8396717] synonym: "G-protein coupled receptor internalization" EXACT [] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway [Term] id: GO:0002032 name: desensitization of G protein-coupled receptor signaling pathway by arrestin namespace: biological_process def: "The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "desensitization of G-protein coupled receptor protein signaling pathway by arrestin" EXACT [] is_a: GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway is_a: GO:0032091 ! negative regulation of protein binding [Term] id: GO:0002033 name: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the diameter of a blood vessel via the renin-angiotensin system." [GOC:pr, ISBN:0323031951, PMID:10425188] synonym: "vasodilation by angiotensin involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002034 ! regulation of blood vessel diameter by renin-angiotensin [Term] id: GO:0002034 name: regulation of blood vessel diameter by renin-angiotensin namespace: biological_process def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:pr, GOC:tb] synonym: "regulation of blood vessel size by renin-angiotensin" BROAD [] synonym: "renin-angiotensin regulation of blood vessel size" BROAD [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin is_a: GO:0097746 ! regulation of blood vessel diameter [Term] id: GO:0002035 name: brain renin-angiotensin system namespace: biological_process def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002036 name: regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900920 def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] synonym: "regulation of L-glutamate transport" BROAD [] synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane created_by: al creation_date: 2012-06-13T07:34:08Z [Term] id: GO:0002037 name: negative regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900921 def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamate transport" BROAD [] synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamate transport" BROAD [] synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamate transport" BROAD [] synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamate transport" NARROW [] synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of L-glutamate import" BROAD [] synonym: "negative regulation of L-glutamate transport" BROAD [] synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane created_by: al creation_date: 2012-06-13T07:34:30Z [Term] id: GO:0002038 name: positive regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900922 def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] synonym: "activation of L-glutamate transport" NARROW [] synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-glutamate import" BROAD [] synonym: "positive regulation of L-glutamate transport" BROAD [] synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamate transport" BROAD [] synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate transport" BROAD [] synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane created_by: al creation_date: 2012-06-13T07:34:38Z [Term] id: GO:0002039 name: p53 binding namespace: molecular_function def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002040 name: sprouting angiogenesis namespace: biological_process def: "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation." [PMID:16391003, PMID:23031691] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002041 name: intussusceptive angiogenesis namespace: biological_process def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002042 name: cell migration involved in sprouting angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002043 name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001935 ! endothelial cell proliferation relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002044 name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002045 name: regulation of cell adhesion involved in intussusceptive angiogenesis namespace: biological_process def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0030155 ! regulation of cell adhesion intersection_of: part_of GO:0002041 ! intussusceptive angiogenesis relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002046 name: opsin binding namespace: molecular_function alt_id: GO:0016030 def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] synonym: "metarhodopsin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0002047 name: phenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] synonym: "acridizine biosynthesis" RELATED [] synonym: "acridizine biosynthetic process" RELATED [] synonym: "azophenylene biosynthesis" RELATED [] synonym: "azophenylene biosynthetic process" RELATED [] synonym: "dibenzo-p-diazine biosynthesis" RELATED [] synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] synonym: "dibenzopyrazine biosynthesis" RELATED [] synonym: "dibenzopyrazine biosynthetic process" RELATED [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0002048 name: pyoverdine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] synonym: "pyoverdine metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0002049 name: pyoverdine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0002050 name: pyoverdine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0002051 name: osteoblast fate commitment namespace: biological_process def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002054 name: nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0002055 name: adenine binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002056 name: cytosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cytosine." [GOC:hjd, GOC:vw] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002057 name: guanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanine." [GOC:hjd] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002058 name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding is_a: GO:0008144 ! drug binding [Term] id: GO:0002059 name: thymine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thymine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002060 name: purine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton." [GOC:hjd] synonym: "purine base binding" EXACT [GOC:go_curators] synonym: "purine binding" RELATED [] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002061 name: pyrimidine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [GOC:hjd] synonym: "1,3-diazine binding" NARROW [] synonym: "pyrimidine base binding" EXACT [GOC:go_curators] synonym: "pyrimidine binding" RELATED [] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0002062 ! chondrocyte differentiation [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0002067 ! glandular epithelial cell differentiation [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0002068 ! glandular epithelial cell development [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development is_a: GO:0060538 ! skeletal muscle organ development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002075 name: somitomeric trunk muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] is_a: GO:0060538 ! skeletal muscle organ development [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002077 name: acrosome matrix dispersal namespace: biological_process def: "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029] is_a: GO:0022414 ! reproductive process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002078 name: membrane fusion involved in acrosome reaction namespace: biological_process def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0061025 ! membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: part_of GO:0007340 ! acrosome reaction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002079 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0098589 ! membrane region relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0002081 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0098589 ! membrane region relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002082 name: regulation of oxidative phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] synonym: "OXPHOS" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006119 ! oxidative phosphorylation relationship: regulates GO:0006119 ! oxidative phosphorylation [Term] id: GO:0002083 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230] xref: EC:2.5.1.39 xref: MetaCyc:RXN-9230 xref: Reactome:R-HSA-2162192 "PHB and all-E-10PrP2 are combined into DHB by COQ2" is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0002084 name: protein depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] is_a: GO:0035601 ! protein deacylation is_a: GO:0042159 ! lipoprotein catabolic process is_a: GO:0098734 ! macromolecule depalmitoylation [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002086 name: diaphragm contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] is_a: GO:0003011 ! involuntary skeletal muscle contraction is_a: GO:0003016 ! respiratory system process [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0002090 name: regulation of receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031623 ! receptor internalization relationship: regulates GO:0031623 ! receptor internalization [Term] id: GO:0002091 name: negative regulation of receptor internalization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "down regulation of receptor internalization" EXACT [] synonym: "down-regulation of receptor internalization" EXACT [] synonym: "downregulation of receptor internalization" EXACT [] synonym: "inhibition of receptor internalization" NARROW [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031623 ! receptor internalization relationship: negatively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002092 name: positive regulation of receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "activation of receptor internalization" NARROW [] synonym: "stimulation of receptor internalization" NARROW [] synonym: "up regulation of receptor internalization" EXACT [] synonym: "up-regulation of receptor internalization" EXACT [] synonym: "upregulation of receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031623 ! receptor internalization relationship: positively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060117 ! auditory receptor cell development [Term] id: GO:0002094 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0002095 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005901 ! caveola [Term] id: GO:0002096 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002099 name: tRNA wobble guanine modification namespace: biological_process def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002100 name: tRNA wobble adenosine to inosine editing namespace: biological_process def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification is_a: GO:0006382 ! adenosine to inosine editing [Term] id: GO:0002101 name: tRNA wobble cytosine modification namespace: biological_process def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002102 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: Wikipedia:Podosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0002103 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0002104 name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002105 name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002106 name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002107 name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III namespace: biological_process def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] is_a: GO:0000481 ! maturation of 5S rRNA is_a: GO:0031125 ! rRNA 3'-end processing [Term] id: GO:0002108 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0002109 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0002110 name: cotranscriptional mitochondrial rRNA nucleotide insertion namespace: biological_process def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965] is_a: GO:0000154 ! rRNA modification is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0002111 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0002112 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd] synonym: "IL-33" NARROW [GOC:mah] synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0002113 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd] synonym: "IL-33 binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0002114 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "IL-33 receptor activity" EXACT [GOC:mah] synonym: "IL-33R" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0002113 ! interleukin-33 binding relationship: part_of GO:0038172 ! interleukin-33-mediated signaling pathway [Term] id: GO:0002115 name: store-operated calcium entry namespace: biological_process def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. synonym: "calcium ion import" BROAD [] synonym: "capacitative calcium entry" EXACT [] synonym: "SOCE" EXACT [] synonym: "store-operated calcium import" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0002116 name: semaphorin receptor complex namespace: cellular_component def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] synonym: "plexin-neurophilin complex" EXACT [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002117 name: amphibian larval development namespace: biological_process def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/] is_a: GO:0002164 ! larval development [Term] id: GO:0002118 name: aggressive behavior namespace: biological_process def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] synonym: "aggression" EXACT [] xref: Wikipedia:Aggression is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development [Term] id: GO:0002120 name: predatory behavior namespace: biological_process def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd] synonym: "predatory aggression" EXACT [] synonym: "predatory aggressive behavior" EXACT [] is_a: GO:0002118 ! aggressive behavior is_a: GO:0044366 ! feeding on or from other organism [Term] id: GO:0002121 name: inter-male aggressive behavior namespace: biological_process def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] synonym: "inter-male aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002122 name: fear-induced aggressive behavior namespace: biological_process def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] synonym: "fear-induced aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002123 name: irritable aggressive behavior namespace: biological_process def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] synonym: "irritable aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002124 name: territorial aggressive behavior namespace: biological_process def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] synonym: "territorial aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002125 name: maternal aggressive behavior namespace: biological_process def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] comment: Paternal aggression also exists. Serves to protect the offspring from intruders. synonym: "maternal aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002126 name: instrumental aggressive behavior namespace: biological_process def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] synonym: "instrumental aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002127 name: tRNA wobble base cytosine methylation namespace: biological_process def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] synonym: "wobble position m5C biosynthesis" EXACT [] is_a: GO:0002101 ! tRNA wobble cytosine modification is_a: GO:0002946 ! tRNA C5-cytosine methylation [Term] id: GO:0002128 name: tRNA nucleoside ribose methylation namespace: biological_process def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002129 name: wobble position guanine ribose methylation namespace: biological_process def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation is_a: GO:0002938 ! tRNA guanine ribose methylation [Term] id: GO:0002130 name: wobble position ribose methylation namespace: biological_process def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002131 name: wobble position cytosine ribose methylation namespace: biological_process def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002132 name: wobble position uridine ribose methylation namespace: biological_process def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002133 name: polycystin complex namespace: cellular_component def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002134 name: UTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732] is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002135 name: CTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607] is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002136 name: tRNA wobble base lysidine biosynthesis namespace: biological_process def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. is_a: GO:0002101 ! tRNA wobble cytosine modification [Term] id: GO:0002138 name: retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] synonym: "retinoic acid anabolic process" EXACT [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process created_by: hjd creation_date: 2009-05-01T10:53:24Z [Term] id: GO:0002139 name: stereocilia coupling link namespace: cellular_component def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032421 ! stereocilium bundle created_by: hjd creation_date: 2009-05-06T10:25:38Z [Term] id: GO:0002140 name: stereocilia tip link namespace: cellular_component def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] is_a: GO:0002139 ! stereocilia coupling link created_by: hjd creation_date: 2009-05-06T10:28:10Z [Term] id: GO:0002141 name: stereocilia ankle link namespace: cellular_component def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] is_a: GO:0002139 ! stereocilia coupling link created_by: hjd creation_date: 2009-05-06T10:31:56Z [Term] id: GO:0002142 name: stereocilia ankle link complex namespace: cellular_component def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0002141 ! stereocilia ankle link created_by: hjd creation_date: 2009-05-06T10:33:57Z [Term] id: GO:0002143 name: tRNA wobble position uridine thiolation namespace: biological_process def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] synonym: "wobble position s2U biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0034227 ! tRNA thio-modification created_by: hjd creation_date: 2009-05-06T05:05:40Z [Term] id: GO:0002144 name: cytosolic tRNA wobble base thiouridylase complex namespace: cellular_component def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219] synonym: "Cut1-Cut2 complex" NARROW [] synonym: "tRNA thiouridylase" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: hjd creation_date: 2009-05-08T02:32:55Z [Term] id: GO:0002145 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543] synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] xref: MetaCyc:RXN0-3543 is_a: GO:0016462 ! pyrophosphatase activity created_by: hjd creation_date: 2009-06-10T11:21:35Z [Term] id: GO:0002146 name: obsolete steroid hormone receptor import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 consider: GO:0042306 created_by: hjd creation_date: 2009-07-09T02:34:42Z [Term] id: GO:0002147 name: obsolete glucocorticoid receptor import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah] is_obsolete: true consider: GO:0042306 created_by: hjd creation_date: 2009-07-09T02:36:09Z [Term] id: GO:0002148 name: hypochlorous acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] synonym: "HClO metabolic process" EXACT [] synonym: "HOCl metabolic process" EXACT [] synonym: "hypochlorite metabolic process" RELATED [] synonym: "hypochlorous acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process created_by: hjd creation_date: 2009-10-13T10:27:48Z [Term] id: GO:0002149 name: hypochlorous acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. synonym: "HClO biosynthetic process" EXACT [] synonym: "HOCl biosynthetic process" EXACT [] synonym: "hypochlorite biosynthetic process" RELATED [] synonym: "hypochlorous acid biosynthesis" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process created_by: hjd creation_date: 2009-10-13T10:32:35Z [Term] id: GO:0002150 name: hypochlorous acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] synonym: "HClO catabolic process" EXACT [] synonym: "HOCl catabolic process" EXACT [] synonym: "hypochlorite catabolic process" RELATED [] synonym: "hypochlorous acid catabolism" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044282 ! small molecule catabolic process created_by: hjd creation_date: 2009-10-13T10:36:09Z [Term] id: GO:0002151 name: G-quadruplex RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. synonym: "G quadruplex binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:hjd] synonym: "G quartet RNA binding" EXACT [GOC:hjd] synonym: "G-quartet binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding created_by: hjd creation_date: 2009-10-22T01:38:02Z [Term] id: GO:0002152 name: bile acid conjugation namespace: biological_process def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). is_a: GO:0008206 ! bile acid metabolic process created_by: hjd creation_date: 2009-10-29T01:41:51Z [Term] id: GO:0002153 name: steroid receptor RNA activator RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993] comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). synonym: "SRA binding" EXACT [] is_a: GO:0003727 ! single-stranded RNA binding created_by: hjd creation_date: 2009-11-16T02:18:55Z [Term] id: GO:0002154 name: thyroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway created_by: hjd creation_date: 2009-11-19T12:36:29Z [Term] id: GO:0002155 name: regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:37:46Z [Term] id: GO:0002156 name: negative regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:41:48Z [Term] id: GO:0002157 name: positive regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:42:57Z [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation created_by: hjd creation_date: 2010-02-03T01:50:37Z [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0007043 ! cell-cell junction assembly created_by: hjd creation_date: 2010-02-09T10:46:30Z [Term] id: GO:0002160 name: desmosome maintenance namespace: biological_process def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0045217 ! cell-cell junction maintenance created_by: hjd creation_date: 2010-02-09T10:50:59Z [Term] id: GO:0002161 name: aminoacyl-tRNA editing activity namespace: molecular_function def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] synonym: "amino acid proofreading activity" RELATED [] synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0106074 ! aminoacyl-tRNA metabolism involved in translational fidelity created_by: hjd creation_date: 2010-02-12T03:06:56Z [Term] id: GO:0002162 name: dystroglycan binding namespace: molecular_function alt_id: GO:0002163 alt_id: GO:0002166 def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] synonym: "alpha-dystroglycan binding" NARROW [] synonym: "beta-dystroglycan binding" NARROW [] is_a: GO:0005515 ! protein binding created_by: hjd creation_date: 2010-02-22T02:17:58Z [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002167 name: VRK3/VHR/ERK complex namespace: cellular_component def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] is_a: GO:0032991 ! protein-containing complex created_by: hjd creation_date: 2010-03-04T01:15:05Z [Term] id: GO:0002168 name: instar larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002164 ! larval development is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0002169 name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial namespace: cellular_component def: "A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, PMID:15868465, PMID:17360195, PMID:22869039] synonym: "mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme" EXACT [PMID:22869039] synonym: "mitochondrial MCCC complex" EXACT [GOC:bf] synonym: "mitochondrial methylcrotonoyl-CoA carboxylase complex" EXACT [GOC:bf] is_a: GO:0098798 ! mitochondrial protein complex is_a: GO:1905202 ! methylcrotonoyl-CoA carboxylase complex created_by: hjd creation_date: 2010-03-15T04:58:08Z [Term] id: GO:0002170 name: high-affinity IgA receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "high affinity IgA receptor activity" EXACT [] is_a: GO:0019766 ! IgA receptor activity created_by: hjd creation_date: 2010-05-06T05:00:11Z [Term] id: GO:0002171 name: low-affinity IgA receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "low affinity IgA receptor activity" EXACT [] is_a: GO:0019766 ! IgA receptor activity created_by: hjd creation_date: 2010-05-06T05:01:41Z [Term] id: GO:0002172 name: high-affinity IgM receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "high affinity IgM receptor activity" EXACT [] is_a: GO:0001793 ! IgM receptor activity created_by: hjd creation_date: 2010-05-06T05:03:26Z [Term] id: GO:0002173 name: low-affinity IgM receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "low affinity IgM receptor activity" EXACT [] is_a: GO:0001793 ! IgM receptor activity created_by: hjd creation_date: 2010-05-06T05:04:24Z [Term] id: GO:0002174 name: mammary stem cell proliferation namespace: biological_process def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0030879 ! mammary gland development created_by: hjd creation_date: 2010-09-14T01:19:45Z [Term] id: GO:0002175 name: protein localization to paranode region of axon namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321] synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0099612 ! protein localization to axon created_by: hjd creation_date: 2010-11-15T10:28:20Z [Term] id: GO:0002176 name: male germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] is_a: GO:0036093 ! germ cell proliferation created_by: hjd creation_date: 2010-11-18T02:35:14Z [Term] id: GO:0002177 name: manchette namespace: cellular_component def: "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments." [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0015630 ! microtubule cytoskeleton created_by: hjd creation_date: 2010-12-01T02:31:43Z [Term] id: GO:0002178 name: palmitoyltransferase complex namespace: cellular_component def: "A protein complex with palmitoyltransferase activity." [GOC:hjd] is_a: GO:1990234 ! transferase complex created_by: hjd creation_date: 2010-12-03T10:49:17Z [Term] id: GO:0002179 name: homodimeric serine palmitoyltransferase complex namespace: cellular_component def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd] comment: This complex occurs primarily in bacteria. is_a: GO:0017059 ! serine C-palmitoyltransferase complex created_by: hjd creation_date: 2010-12-03T10:50:59Z [Term] id: GO:0002180 name: 5-lipoxygenase complex namespace: cellular_component def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0031965 ! nuclear membrane created_by: hjd creation_date: 2011-06-09T01:05:53Z [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. subset: goslim_drosophila subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation created_by: hjd creation_date: 2011-06-09T03:11:53Z [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: part_of GO:0002181 ! cytoplasmic translation relationship: part_of GO:0002181 ! cytoplasmic translation created_by: hjd creation_date: 2011-06-09T03:14:42Z [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: part_of GO:0002181 ! cytoplasmic translation relationship: part_of GO:0002181 ! cytoplasmic translation created_by: hjd creation_date: 2011-06-09T03:15:48Z [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol relationship: part_of GO:0002181 ! cytoplasmic translation created_by: hjd creation_date: 2011-06-09T03:17:13Z [Term] id: GO:0002185 name: creatine kinase complex namespace: cellular_component def: "A protein complex having creatine kinase activity." [GOC:hjd] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: hjd creation_date: 2011-06-14T02:12:19Z [Term] id: GO:0002186 name: cytosolic creatine kinase complex namespace: cellular_component def: "A dimeric protein complex having creatine kinase activity." [PMID:173175] is_a: GO:0002185 ! creatine kinase complex intersection_of: GO:0002185 ! creatine kinase complex intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol created_by: hjd creation_date: 2011-06-14T02:14:16Z [Term] id: GO:0002187 name: mitochondrial creatine kinase complex namespace: cellular_component def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486] is_a: GO:0002185 ! creatine kinase complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0002185 ! creatine kinase complex intersection_of: part_of GO:0005739 ! mitochondrion created_by: hjd creation_date: 2011-06-14T02:15:29Z [Term] id: GO:0002188 name: translation reinitiation namespace: biological_process def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792] is_a: GO:0002183 ! cytoplasmic translational initiation created_by: hjd creation_date: 2011-06-22T12:31:13Z [Term] id: GO:0002189 name: ribose phosphate diphosphokinase complex namespace: cellular_component def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095] comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits. synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095] synonym: "PRPP synthetase complex" EXACT [PMID:9348095] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: hjd creation_date: 2011-06-27T02:49:33Z [Term] id: GO:0002190 name: cap-independent translational initiation namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation." [PMID:17284590] is_a: GO:0002183 ! cytoplasmic translational initiation created_by: hjd creation_date: 2011-08-11T02:16:05Z [Term] id: GO:0002191 name: cap-dependent translational initiation namespace: biological_process def: "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130] is_a: GO:0002183 ! cytoplasmic translational initiation created_by: hjd creation_date: 2011-08-11T02:20:24Z [Term] id: GO:0002192 name: IRES-dependent translational initiation of linear mRNA namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [PMID:17284590] is_a: GO:0110017 ! cap-independent translational initiation of linear mRNA created_by: hjd creation_date: 2011-08-11T02:32:45Z [Term] id: GO:0002193 name: MAML1-RBP-Jkappa- ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869] synonym: "MAML1-CSL-ICN1" EXACT [] synonym: "MAML1-CSL-Notch1 complex" EXACT [] synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: hjd creation_date: 2011-08-11T04:08:18Z [Term] id: GO:0002194 name: hepatocyte cell migration namespace: biological_process def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819] is_a: GO:0016477 ! cell migration created_by: hjd creation_date: 2011-08-30T04:27:39Z [Term] id: GO:0002195 name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729] comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli. is_a: GO:0006400 ! tRNA modification created_by: hjd creation_date: 2011-08-31T02:20:06Z [Term] id: GO:0002196 name: Ser-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375] is_a: GO:0002161 ! aminoacyl-tRNA editing activity created_by: hjd creation_date: 2011-09-30T02:18:50Z [Term] id: GO:0002197 name: xanthine dehydrogenase complex namespace: cellular_component def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915] is_a: GO:1990204 ! oxidoreductase complex created_by: hjd creation_date: 2011-10-03T03:55:57Z [Term] id: GO:0002198 name: obsolete S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "S/G2 transition of mitotic cell cycle" EXACT [] is_obsolete: true created_by: hjd creation_date: 2011-11-02T10:36:58Z [Term] id: GO:0002199 name: zona pellucida receptor complex namespace: cellular_component def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] synonym: "sperm protein complex I" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0005832 ! chaperonin-containing T-complex created_by: hjd creation_date: 2011-12-23T01:33:23Z [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002201 name: somatic diversification of DSCAM-based immune receptors namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174] comment: Note that this type of immune receptor may not be limited to insects. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002202 name: somatic diversification of variable lymphocyte receptors of jawless fish namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579] comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002203 name: proteolysis by cytosolic proteases associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002205 name: somatic hypermutation of immunoglobulin genes involved in immune response namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701] synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: part_of GO:0002344 ! B cell affinity maturation [Term] id: GO:0002206 name: gene conversion of immunoglobulin genes namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes" EXACT [] is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion is_a: GO:0016445 ! somatic diversification of immunoglobulins is_a: GO:0035822 ! gene conversion [Term] id: GO:0002207 name: gene conversion of immunoglobulin genes involved in immune response namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes during immune response" RELATED [] synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002206 ! gene conversion of immunoglobulin genes is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002209 name: behavioral defense response namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural defense response" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0007610 ! behavior [Term] id: GO:0002210 name: behavioral response to wounding namespace: biological_process def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural response to wounding" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009611 ! response to wounding [Term] id: GO:0002211 name: behavioral defense response to insect namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "behavioural defense response to insect" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002213 ! defense response to insect is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002212 name: behavioral defense response to nematode namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] synonym: "behavioural defense response to nematode" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002215 ! defense response to nematode is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002213 name: defense response to insect namespace: biological_process alt_id: GO:0002214 def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process alt_id: GO:0002216 def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002218 name: activation of innate immune response namespace: biological_process alt_id: GO:0002219 def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] comment: This term was added by GO_REF:0000022. is_a: GO:0002253 ! activation of immune response is_a: GO:0045089 ! positive regulation of innate immune response [Term] id: GO:0002220 name: innate immune response activating cell surface receptor signaling pathway namespace: biological_process def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002221 name: pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002222 name: stimulatory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002223 name: stimulatory C-type lectin receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002224 name: toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. synonym: "TLR signaling pathway" EXACT [ISBN:0781735149] synonym: "toll-like receptor signalling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002760 ! positive regulation of antimicrobial humoral response is_a: GO:0002784 ! regulation of antimicrobial peptide production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002775 ! antimicrobial peptide production relationship: positively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002229 name: defense response to oomycetes namespace: biological_process def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] is_a: GO:0002239 ! response to oomycetes is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002230 name: positive regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "activation of antiviral response by host" NARROW [] synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of antiviral response by host" NARROW [] synonym: "up regulation of antiviral response by host" EXACT [] synonym: "up-regulation of antiviral response by host" EXACT [] synonym: "upregulation of antiviral response by host" EXACT [] is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0002231 name: detection of oomycetes namespace: biological_process def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] is_a: GO:0002239 ! response to oomycetes is_a: GO:0098543 ! detection of other organism [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002234 name: detection of endoplasmic reticulum overloading namespace: biological_process def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] synonym: "detection of ER overloading" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002235 name: detection of unfolded protein namespace: biological_process def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0002236 name: detection of misfolded protein namespace: biological_process def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051788 ! response to misfolded protein [Term] id: GO:0002237 name: response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] synonym: "response to bacteria associated molecule" EXACT [] synonym: "response to bacterial associated molecule" EXACT [] synonym: "response to bacterium associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0009617 ! response to bacterium [Term] id: GO:0002238 name: response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] synonym: "response to fungus associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0002239 name: response to oomycetes namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] is_a: GO:0051707 ! response to other organism [Term] id: GO:0002240 name: response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] synonym: "response to oomycetes associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0002239 ! response to oomycetes [Term] id: GO:0002241 name: response to parasitic plant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0002242 name: defense response to parasitic plant namespace: biological_process def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002243 name: detection of parasitic plant namespace: biological_process def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0009602 ! detection of symbiont [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing intersection_of: GO:0042060 ! wound healing intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0090594 ! inflammatory response to wounding [Term] id: GO:0002247 name: clearance of damaged tissue involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002248 name: connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] is_a: GO:0097709 ! connective tissue replacement relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "acquired immune response" EXACT [ISBN:068340007X] synonym: "immune memory response" EXACT [GOC:add] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process [Term] id: GO:0002253 name: activation of immune response namespace: biological_process def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002254 name: kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002526 ! acute inflammatory response is_a: GO:0072376 ! protein activation cascade [Term] id: GO:0002255 name: tissue kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] synonym: "glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002256 name: regulation of kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002254 ! kinin cascade relationship: regulates GO:0002254 ! kinin cascade [Term] id: GO:0002257 name: negative regulation of kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "down regulation of kinin cascade" EXACT [] synonym: "down-regulation of kinin cascade" EXACT [] synonym: "downregulation of kinin cascade" EXACT [] synonym: "inhibition of kinin cascade" NARROW [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:2000258 ! negative regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002254 ! kinin cascade relationship: negatively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002258 name: positive regulation of kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "activation of kinin cascade" NARROW [] synonym: "stimulation of kinin cascade" NARROW [] synonym: "up regulation of kinin cascade" EXACT [] synonym: "up-regulation of kinin cascade" EXACT [] synonym: "upregulation of kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:2000259 ! positive regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002254 ! kinin cascade relationship: positively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002259 name: endothelial cell activation within high endothelial venule involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] is_a: GO:0002264 ! endothelial cell activation involved in immune response [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002261 name: mucosal lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation intersection_of: GO:0042118 ! endothelial cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation intersection_of: GO:0048143 ! astrocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0001775 ! cell activation [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0002266 ! follicular dendritic cell activation intersection_of: GO:0002266 ! follicular dendritic cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response intersection_of: GO:0002270 ! plasmacytoid dendritic cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation intersection_of: GO:0002273 ! plasmacytoid dendritic cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045575 ! basophil activation intersection_of: GO:0045575 ! basophil activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation intersection_of: GO:0043307 ! eosinophil activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation intersection_of: GO:0045576 ! mast cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation intersection_of: GO:0042117 ! monocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] synonym: "macrophage polarization involved in immune response" EXACT [] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response intersection_of: GO:0001774 ! microglial cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation intersection_of: GO:0042119 ! neutrophil activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation intersection_of: GO:0046631 ! alpha-beta T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation intersection_of: GO:0051132 ! NK T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response intersection_of: GO:0001866 ! NK T cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation intersection_of: GO:0046629 ! gamma-delta T cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002291 name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation intersection_of: GO:0046632 ! alpha-beta T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation intersection_of: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002295 name: T-helper cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149] synonym: "T-helper cell fate commitment" EXACT [] synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149] synonym: "Thp lineage commitment" RELATED [ISBN:0781735149] is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0042093 ! T-helper cell differentiation [Term] id: GO:0002296 name: T-helper 1 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149] synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149] synonym: "Th1 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0002297 name: T-helper 2 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149] synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th2 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation intersection_of: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation intersection_of: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation intersection_of: GO:0042492 ! gamma-delta T cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0042098 ! T cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation intersection_of: GO:0046633 ! alpha-beta T cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation intersection_of: GO:0046630 ! gamma-delta T cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation intersection_of: GO:0042113 ! B cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B cell development involved in immune response" RELATED [GOC:add] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation intersection_of: GO:0002335 ! mature B cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "germinal center B cell development" RELATED [GOC:add] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "marginal zone B cell development" RELATED [GOC:add] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "follicular B cell development" RELATED [GOC:add] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "plasma cell development" RELATED [GOC:add] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory B cell development" RELATED [GOC:add] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response is_a: GO:0090715 ! immunological memory formation process [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation intersection_of: GO:0042100 ! B cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation intersection_of: GO:0030101 ! natural killer cell activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002323 ! natural killer cell activation involved in immune response intersection_of: GO:0001787 ! natural killer cell proliferation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002323 ! natural killer cell activation involved in immune response intersection_of: GO:0001779 ! natural killer cell differentiation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002326 name: B cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte lineage commitment" EXACT [] synonym: "B-cell lineage commitment" EXACT [] synonym: "B-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "immature B cell development" RELATED [GOC:add] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149] synonym: "pro-B cell development" RELATED [GOC:add] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "pre-B cell development" RELATED [GOC:add] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002330 name: pre-B cell receptor expression namespace: biological_process def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:add, GOC:jal, ISBN:0781735149] is_a: GO:0010467 ! gene expression relationship: part_of GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002331 name: pre-B cell allelic exclusion namespace: biological_process def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "pre-B lymphocyte allelic exclusion" EXACT [] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "transitional stage B cell development" RELATED [GOC:add] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002333 name: transitional one stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T1 stage B cell differentiation" EXACT [] synonym: "transitional one stage B cell development" RELATED [GOC:add] synonym: "transitional one stage B lymphocyte differentiation" EXACT [] synonym: "transitional one stage B-cell differentiation" EXACT [] synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002334 name: transitional two stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T2 stage B cell differentiation" EXACT [] synonym: "transitional two stage B cell development" RELATED [GOC:add] synonym: "transitional two stage B lymphocyte differentiation" EXACT [] synonym: "transitional two stage B-cell differentiation" EXACT [] synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] synonym: "mature cell development" RELATED [GOC:add] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002336 name: B-1 B cell lineage commitment namespace: biological_process def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149] synonym: "B-1 B lymphocyte lineage commitment" EXACT [] synonym: "B-1 B-cell lineage commitment" EXACT [] synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] is_a: GO:0002326 ! B cell lineage commitment relationship: part_of GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1a B cell development" RELATED [GOC:add] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1b B cell development" RELATED [GOC:add] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002340 name: central B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] synonym: "central B lymphocyte selection" EXACT [] synonym: "central B-cell selection" EXACT [] synonym: "central B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002341 name: central B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte anergy" EXACT [] synonym: "central B-cell anergy" EXACT [] synonym: "central B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002342 name: central B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis] synonym: "central B lymphocyte deletion" EXACT [] synonym: "central B-cell deletion" EXACT [] synonym: "central B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002345 name: peripheral B cell receptor editing namespace: biological_process def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] synonym: "peripheral B lymphocyte receptor editing" EXACT [] synonym: "peripheral B-cell receptor editing" EXACT [] synonym: "peripheral B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002346 name: B cell positive selection namespace: biological_process def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] synonym: "B lymphocyte positive selection" EXACT [] synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002347 name: response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0002348 name: central B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "central B lymphocyte positive selection" EXACT [] synonym: "central B-cell positive selection" EXACT [] synonym: "central B-lymphocyte positive selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002350 name: peripheral B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "peripheral B lymphocyte positive selection" EXACT [] synonym: "peripheral B-cell positive selection" EXACT [] synonym: "peripheral B-lymphocyte positive selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002352 name: B cell negative selection namespace: biological_process def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] synonym: "B lymphocyte negative selection" EXACT [] synonym: "B-cell negative selection" EXACT [] synonym: "B-lymphocyte negative selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002353 name: plasma kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002354 name: central B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte negative selection" EXACT [] synonym: "central B-cell negative selection" EXACT [] synonym: "central B-lymphocyte negative selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002355 name: detection of tumor cell namespace: biological_process def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002356 name: peripheral B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte negative selection" EXACT [] synonym: "peripheral B-cell negative selection" EXACT [] synonym: "peripheral B-lymphocyte negative selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002357 name: defense response to tumor cell namespace: biological_process def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006952 ! defense response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation relationship: part_of GO:0042592 ! homeostatic process [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002360 name: T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte lineage commitment" EXACT [] synonym: "T-cell lineage commitment" EXACT [] synonym: "T-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002362 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002363 name: alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "alpha-beta T-cell lineage commitment" EXACT [] synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002364 name: NK T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149] synonym: "natural killer T lymphocyte lineage commitment" EXACT [] synonym: "natural killer T-cell lineage commitment" EXACT [] synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] synonym: "NK T lymphocyte lineage commitment" EXACT [] synonym: "NK T-cell lineage commitment" EXACT [] synonym: "NK T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002363 ! alpha-beta T cell lineage commitment relationship: part_of GO:0001865 ! NK T cell differentiation [Term] id: GO:0002365 name: gamma-delta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149] synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] synonym: "gamma-delta T-cell lineage commitment" EXACT [] synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: part_of GO:0006955 ! immune response [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. synonym: "cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149] synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002374 name: cytokine secretion involved in immune response namespace: biological_process def: "The regulated release of cytokines from a cell that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0050663 ! cytokine secretion intersection_of: GO:0050663 ! cytokine secretion intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002375 name: cytokine biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0042089 ! cytokine biosynthetic process intersection_of: GO:0042089 ! cytokine biosynthetic process intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production" EXACT [] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002378 name: immunoglobulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis" EXACT [] synonym: "antibody biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0002379 name: immunoglobulin biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis during immune response" RELATED [] synonym: "antibody biosynthetic process during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002378 ! immunoglobulin biosynthetic process intersection_of: GO:0002378 ! immunoglobulin biosynthetic process intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002380 name: immunoglobulin secretion involved in immune response namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph] is_a: GO:0048305 ! immunoglobulin secretion intersection_of: GO:0048305 ! immunoglobulin secretion intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production during immune response" RELATED [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] is_a: GO:0002377 ! immunoglobulin production intersection_of: GO:0002377 ! immunoglobulin production intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002382 name: regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002383 name: immune response in brain or nervous system namespace: biological_process def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149] synonym: "immune response in MALT" EXACT [] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149] synonym: "immune response in GALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue [Term] id: GO:0002390 name: platelet activating factor production namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] is_a: GO:0001816 ! cytokine production [Term] id: GO:0002391 name: platelet activating factor production involved in inflammatory response namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor production involved in acute inflammatory response" BROAD [] is_a: GO:0002390 ! platelet activating factor production is_a: GO:0002534 ! cytokine production involved in inflammatory response intersection_of: GO:0002390 ! platelet activating factor production intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002392 name: platelet activating factor secretion namespace: biological_process def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149] is_a: GO:0010876 ! lipid localization is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0015893 ! drug transport is_a: GO:0015914 ! phospholipid transport is_a: GO:0050663 ! cytokine secretion is_a: GO:0140353 ! lipid export from cell [Term] id: GO:0002393 name: lysosomal enzyme production involved in inflammatory response namespace: biological_process def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149] synonym: "immune response in NALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0002397 name: MHC class I protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002398 name: MHC class Ib protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149] synonym: "tolerance induction in MALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002404 name: antigen sampling in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] synonym: "antigen sampling in MALT" EXACT [] synonym: "antigen transport in MALT" RELATED [] synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002405 name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] synonym: "antigen sampling by dendritic cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002406 name: antigen sampling by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] synonym: "antigen sampling by M cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002411 name: T cell tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002413 ! tolerance induction to tumor cell is_a: GO:0002424 ! T cell mediated immune response to tumor cell is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002412 name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411] synonym: "antigen transcytosis by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] is_a: GO:0045056 ! transcytosis relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue [Term] id: GO:0002413 name: tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002414 name: immunoglobulin transcytosis in epithelial cells namespace: biological_process def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] is_a: GO:0045056 ! transcytosis [Term] id: GO:0002415 name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor namespace: biological_process def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] synonym: "antibody transcytosis mediated by pIgR" EXACT [] synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002416 name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor namespace: biological_process def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X] synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells [Term] id: GO:0002417 name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis [Term] id: GO:0002418 name: immune response to tumor cell namespace: biological_process def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006955 ! immune response [Term] id: GO:0002419 name: T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001913 ! T cell mediated cytotoxicity is_a: GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002420 name: natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell is_a: GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0002421 name: B cell antigen processing and presentation following pinocytosis namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002422 name: immune response in urogenital tract namespace: biological_process def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002423 name: natural killer cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002418 ! immune response to tumor cell [Term] id: GO:0002424 name: T cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002425 name: tolerance induction in urogenital tract namespace: biological_process def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] is_a: GO:0002422 ! immune response in urogenital tract is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002426 name: immunoglobulin production in mucosal tissue namespace: biological_process def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] synonym: "antibody production in mucosal tissue" EXACT [] is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002385 ! mucosal immune response [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002428 name: antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002429 name: immune response-activating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002757 ! immune response-activating signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002430 name: complement receptor mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "complement receptor mediated signalling pathway" EXACT [] synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002431 name: Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002433 name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis namespace: biological_process def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah] synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [GO_REF:0000022] is_a: GO:0002252 ! immune effector process is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway intersection_of: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway intersection_of: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0002434 name: immune complex clearance namespace: biological_process def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process [Term] id: GO:0002435 name: immune complex clearance by erythrocytes namespace: biological_process def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002436 name: immune complex clearance by monocytes and macrophages namespace: biological_process def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002439 name: chronic inflammatory response to antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0001821 ! histamine secretion intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0019724 ! B cell mediated immunity [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002452 name: B cell receptor editing namespace: biological_process def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte receptor editing" EXACT [] synonym: "B-cell receptor editing" EXACT [] synonym: "B-lymphocyte receptor editing" EXACT [] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002453 name: peripheral B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte anergy" EXACT [] synonym: "peripheral B-cell anergy" EXACT [] synonym: "peripheral B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002454 name: peripheral B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "peripheral B lymphocyte deletion" EXACT [] synonym: "peripheral B-cell deletion" EXACT [] synonym: "peripheral B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002455 name: humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "circulating antibody mediated immune response" EXACT [] synonym: "circulating immunoglobulin mediated immune response" EXACT [] synonym: "humoral defence mechanism" RELATED [] synonym: "humoral immune response mediated by circulating antibody" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0002456 ! T cell mediated immunity [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002459 name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] synonym: "adaptive immune response in jawless fish" EXACT [] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002463 name: central tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002508 ! central tolerance induction [Term] id: GO:0002464 name: peripheral tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002466 name: peripheral tolerance induction to self antigen namespace: biological_process def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002473 name: non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002475 name: antigen processing and presentation via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002476 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0002477 name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002479 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002480 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002481 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002482 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002484 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002485 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002486 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002487 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002488 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib [Term] id: GO:0002489 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002490 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002492 name: peptide antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002493 name: lipid antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0065005 ! protein-lipid complex assembly relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002494 name: lipid antigen transport namespace: biological_process def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process intersection_of: GO:0006508 ! proteolysis intersection_of: part_of GO:0048002 ! antigen processing and presentation of peptide antigen relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002497 name: proteasomal proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002498 name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002499 name: proteolysis within endosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: occurs_in GO:0005768 ! endosome relationship: occurs_in GO:0005768 ! endosome [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation intersection_of: occurs_in GO:0005764 ! lysosome relationship: occurs_in GO:0005764 ! lysosome [Term] id: GO:0002501 name: peptide antigen assembly with MHC protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0002396 ! MHC protein complex assembly relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002502 name: peptide antigen assembly with MHC class I protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002397 ! MHC class I protein complex assembly relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002503 name: peptide antigen assembly with MHC class II protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002505 name: antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002508 name: central tolerance induction namespace: biological_process def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002509 name: central tolerance induction to self antigen namespace: biological_process def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002510 name: central B cell tolerance induction namespace: biological_process def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte tolerance induction" EXACT [] synonym: "central B-cell tolerance induction" EXACT [] synonym: "central B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002511 name: central B cell receptor editing namespace: biological_process def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte receptor editing" EXACT [] synonym: "central B-cell receptor editing" EXACT [] synonym: "central B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002512 name: central T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149] synonym: "central T lymphocyte tolerance induction" EXACT [] synonym: "central T-cell tolerance induction" EXACT [] synonym: "central T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002513 name: tolerance induction to self antigen namespace: biological_process def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptotic process is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0001783 ! B cell apoptotic process intersection_of: part_of GO:0002514 ! B cell tolerance induction relationship: part_of GO:0002514 ! B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002518 name: lymphocyte chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149] synonym: "hypersensitivity response" RELATED [ISBN:0781735149] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002525 name: acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002527 name: vasodilation involved in acute inflammatory response namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0042311 ! vasodilation intersection_of: GO:0042311 ! vasodilation intersection_of: part_of GO:0002526 ! acute inflammatory response relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability intersection_of: GO:0043114 ! regulation of vascular permeability intersection_of: part_of GO:0002526 ! acute inflammatory response relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002529 name: regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] is_a: GO:0002256 ! regulation of kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002530 name: regulation of systemic arterial blood pressure involved in acute-phase response namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] synonym: "blood pressure regulation during acute phase response" RELATED [] synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] is_a: GO:0003073 ! regulation of systemic arterial blood pressure intersection_of: GO:0003073 ! regulation of systemic arterial blood pressure intersection_of: part_of GO:0006953 ! acute-phase response relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002531 name: regulation of heart contraction involved in acute-phase response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] synonym: "regulation of cardiac contraction during acute phase response" RELATED [] synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0008016 ! regulation of heart contraction intersection_of: part_of GO:0006953 ! acute-phase response relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002533 name: lysosomal enzyme secretion involved in inflammatory response namespace: biological_process def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514] synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah] synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [] is_a: GO:0033299 ! secretion of lysosomal enzymes intersection_of: GO:0033299 ! secretion of lysosomal enzymes intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002535 name: platelet activating factor secretion involved in inflammatory response namespace: biological_process def: "The regulated release of platelet activating factor by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD [] is_a: GO:0002392 ! platelet activating factor secretion intersection_of: GO:0002392 ! platelet activating factor secretion intersection_of: part_of GO:0006954 ! inflammatory response relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "oxidative burst during acute inflammatory response" BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002541 name: activation of plasma proteins involved in acute inflammatory response namespace: biological_process def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149] is_a: GO:0016485 ! protein processing relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002542 name: Factor XII activation namespace: biological_process def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] synonym: "Hageman factor activation" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0010954 ! positive regulation of protein processing relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response [Term] id: GO:0002543 name: activation of blood coagulation via clotting cascade namespace: biological_process def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149] synonym: "activation of clotting cascade" EXACT [] is_a: GO:0030194 ! positive regulation of blood coagulation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002545 name: chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002546 name: negative regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002547 name: positive regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002549 name: negative regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002550 name: positive regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097531 ! mast cell migration [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] synonym: "serotonin release by mast cell" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0046907 ! intracellular transport is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0046907 ! intracellular transport is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149] synonym: "serotonin release by platelet" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149] synonym: "serotonin release by basophil" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002558 name: type I hypersensitivity mediated by mast cells namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002448 ! mast cell mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002559 name: type I hypersensitivity mediated by basophils namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002560 ! basophil mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002276 ! basophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002560 ! basophil mediated immunity [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002563 name: somatic diversification of immune receptors via alternate splicing namespace: biological_process def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002564 name: alternate splicing of immunoglobulin genes namespace: biological_process def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563] synonym: "alternate splicing of antibody genes" EXACT [] is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002565 name: somatic diversification of immune receptors via gene conversion namespace: biological_process def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002567 name: somatic diversification of FREP-based immune receptors namespace: biological_process def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575] comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002568 name: somatic diversification of T cell receptor genes namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002569 name: somatic diversification of immune receptors by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002570 name: somatic diversification of immunoglobulin genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of antibody genes by N region addition" EXACT [] is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002571 name: somatic diversification of T cell receptor genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes by N region addition" EXACT [] is_a: GO:0002568 ! somatic diversification of T cell receptor genes is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] synonym: "pro-T lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0071621 ! granulocyte chemotaxis [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019882 ! antigen processing and presentation relationship: regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation relationship: negatively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019882 ! antigen processing and presentation relationship: positively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002592 name: regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002593 name: negative regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002594 name: positive regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002595 name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002596 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002597 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002598 name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002599 name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002600 name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002601 name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002602 name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002603 name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002471 ! monocyte antigen processing and presentation relationship: regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002471 ! monocyte antigen processing and presentation relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002472 ! macrophage antigen processing and presentation relationship: regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002472 ! macrophage antigen processing and presentation relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002619 name: regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002620 name: negative regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002621 name: positive regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002450 ! B cell antigen processing and presentation relationship: regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation is_a: GO:0002713 ! negative regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002450 ! B cell antigen processing and presentation relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation is_a: GO:0002714 ! positive regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002450 ! B cell antigen processing and presentation relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002457 ! T cell antigen processing and presentation relationship: regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002457 ! T cell antigen processing and presentation relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002457 ! T cell antigen processing and presentation relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002432 ! granuloma formation relationship: regulates GO:0002432 ! granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002698 ! negative regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002432 ! granuloma formation relationship: negatively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002699 ! positive regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002432 ! granuloma formation relationship: positively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002467 ! germinal center formation relationship: regulates GO:0002467 ! germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002467 ! germinal center formation relationship: negatively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002467 ! germinal center formation relationship: positively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002377 ! immunoglobulin production relationship: regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002377 ! immunoglobulin production relationship: negatively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002377 ! immunoglobulin production relationship: positively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002640 name: regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002641 name: negative regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] is_a: GO:0002638 ! negative regulation of immunoglobulin production is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002642 name: positive regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "activation of immunoglobulin biosynthetic process" NARROW [] synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002507 ! tolerance induction relationship: regulates GO:0002507 ! tolerance induction [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002507 ! tolerance induction relationship: negatively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002507 ! tolerance induction relationship: positively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002646 name: regulation of central tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002508 ! central tolerance induction relationship: regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002647 name: negative regulation of central tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "down regulation of central tolerance induction" EXACT [] synonym: "down-regulation of central tolerance induction" EXACT [] synonym: "downregulation of central tolerance induction" EXACT [] synonym: "inhibition of central tolerance induction" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002508 ! central tolerance induction relationship: negatively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002648 name: positive regulation of central tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "activation of central tolerance induction" NARROW [] synonym: "stimulation of central tolerance induction" NARROW [] synonym: "up regulation of central tolerance induction" EXACT [] synonym: "up-regulation of central tolerance induction" EXACT [] synonym: "upregulation of central tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002508 ! central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002649 name: regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002513 ! tolerance induction to self antigen relationship: regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002650 name: negative regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "down regulation of tolerance induction to self antigen" EXACT [] synonym: "down-regulation of tolerance induction to self antigen" EXACT [] synonym: "downregulation of tolerance induction to self antigen" EXACT [] synonym: "inhibition of tolerance induction to self antigen" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002513 ! tolerance induction to self antigen relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002651 name: positive regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "activation of tolerance induction to self antigen" NARROW [] synonym: "stimulation of tolerance induction to self antigen" NARROW [] synonym: "up regulation of tolerance induction to self antigen" EXACT [] synonym: "up-regulation of tolerance induction to self antigen" EXACT [] synonym: "upregulation of tolerance induction to self antigen" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002513 ! tolerance induction to self antigen relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002462 ! tolerance induction to nonself antigen relationship: regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002462 ! tolerance induction to nonself antigen relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002465 ! peripheral tolerance induction relationship: regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002465 ! peripheral tolerance induction relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002465 ! peripheral tolerance induction relationship: positively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002514 ! B cell tolerance induction relationship: regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002514 ! B cell tolerance induction relationship: negatively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002514 ! B cell tolerance induction relationship: positively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002517 ! T cell tolerance induction relationship: regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002517 ! T cell tolerance induction relationship: negatively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002517 ! T cell tolerance induction relationship: positively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002870 ! T cell anergy relationship: regulates GO:0002870 ! T cell anergy [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002870 ! T cell anergy relationship: negatively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002870 ! T cell anergy relationship: positively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002515 ! B cell anergy relationship: regulates GO:0002515 ! B cell anergy [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002515 ! B cell anergy relationship: negatively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002515 ! B cell anergy relationship: positively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002526 ! acute inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002526 ! acute inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002526 ! acute inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002544 ! chronic inflammatory response relationship: regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002544 ! chronic inflammatory response relationship: negatively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002544 ! chronic inflammatory response relationship: positively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0006952 ! defense response relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002680 name: pro-T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149] synonym: "pro-T cell fate commitment" EXACT [] synonym: "pro-T lymphocyte fate commitment" EXACT [] synonym: "pro-T lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0002572 ! pro-T cell differentiation [Term] id: GO:0002681 name: somatic recombination of T cell receptor gene segments namespace: biological_process def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of TCR gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002568 ! somatic diversification of T cell receptor genes [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002376 ! immune system process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002376 ! immune system process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002376 ! immune system process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050900 ! leukocyte migration relationship: regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050900 ! leukocyte migration relationship: negatively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050900 ! leukocyte migration relationship: positively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030595 ! leukocyte chemotaxis relationship: regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030595 ! leukocyte chemotaxis relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030595 ! leukocyte chemotaxis relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002691 name: regulation of cellular extravasation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045123 ! cellular extravasation relationship: regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002692 name: negative regulation of cellular extravasation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "down regulation of cellular extravasation" EXACT [] synonym: "down-regulation of cellular extravasation" EXACT [] synonym: "downregulation of cellular extravasation" EXACT [] synonym: "inhibition of cellular extravasation" NARROW [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045123 ! cellular extravasation relationship: negatively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002693 name: positive regulation of cellular extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "activation of cellular extravasation" NARROW [] synonym: "stimulation of cellular extravasation" NARROW [] synonym: "up regulation of cellular extravasation" EXACT [] synonym: "up-regulation of cellular extravasation" EXACT [] synonym: "upregulation of cellular extravasation" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045123 ! cellular extravasation relationship: positively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045321 ! leukocyte activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045321 ! leukocyte activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045321 ! leukocyte activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002252 ! immune effector process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002252 ! immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002252 ! immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002440 ! production of molecular mediator of immune response relationship: regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002440 ! production of molecular mediator of immune response relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002440 ! production of molecular mediator of immune response relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002443 ! leukocyte mediated immunity relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002456 ! T cell mediated immunity relationship: regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002456 ! T cell mediated immunity relationship: negatively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002456 ! T cell mediated immunity relationship: positively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019724 ! B cell mediated immunity relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019724 ! B cell mediated immunity relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019724 ! B cell mediated immunity relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045845 def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002228 ! natural killer cell mediated immunity relationship: regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0030102 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002228 ! natural killer cell mediated immunity relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045846 def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002228 ! natural killer cell mediated immunity relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002367 ! cytokine production involved in immune response relationship: regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002367 ! cytokine production involved in immune response relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002367 ! cytokine production involved in immune response relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002368 ! B cell cytokine production relationship: regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002368 ! B cell cytokine production relationship: negatively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002368 ! B cell cytokine production relationship: positively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002369 ! T cell cytokine production relationship: regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002369 ! T cell cytokine production relationship: negatively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002369 ! T cell cytokine production relationship: positively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002370 ! natural killer cell cytokine production relationship: regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002370 ! natural killer cell cytokine production relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002370 ! natural killer cell cytokine production relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002371 ! dendritic cell cytokine production relationship: regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002371 ! dendritic cell cytokine production relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002371 ! dendritic cell cytokine production relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002739 name: regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response relationship: regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002740 name: negative regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine secretion during immune response" RELATED [] synonym: "down-regulation of cytokine secretion during immune response" RELATED [] synonym: "downregulation of cytokine secretion during immune response" RELATED [] synonym: "inhibition of cytokine secretion during immune response" NARROW [] synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050710 ! negative regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002741 name: positive regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "activation of cytokine secretion during immune response" NARROW [] synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine secretion during immune response" NARROW [] synonym: "up regulation of cytokine secretion during immune response" RELATED [] synonym: "up-regulation of cytokine secretion during immune response" RELATED [] synonym: "upregulation of cytokine secretion during immune response" RELATED [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050715 ! positive regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002742 name: regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002743 name: negative regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002744 name: positive regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002746 name: antigen processing and presentation following pinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002747 name: antigen processing and presentation following phagocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002748 name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149] synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002749 name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122] synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] is_a: GO:0002747 ! antigen processing and presentation following phagocytosis is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen [Term] id: GO:0002750 name: antigen processing and presentation following macropinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002751 name: antigen processing and presentation following receptor mediated endocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002752 name: cell surface pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "cell surface PAMP receptor signaling pathway" EXACT [] synonym: "cell surface pathogen receptor signaling pathway" EXACT [] synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] synonym: "cell surface PRR signaling pathway" EXACT [] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002753 name: cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] synonym: "cytoplasmic PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0002221 ! pattern recognition receptor signaling pathway intersection_of: occurs_in GO:0005737 ! cytoplasm relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0002754 name: intracellular vesicle pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] synonym: "intracellular vesicle PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0002755 name: MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-dependent TLR signaling pathway" EXACT [] synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002756 name: MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-independent TLR signaling pathway" EXACT [] synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002757 name: immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] is_a: GO:0002253 ! activation of immune response is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002758 name: innate immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002757 ! immune response-activating signal transduction [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019730 ! antimicrobial humoral response relationship: regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019730 ! antimicrobial humoral response relationship: positively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002764 name: immune response-regulating signaling pathway namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002765 name: immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002766 name: innate immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571] is_a: GO:0002765 ! immune response-inhibiting signal transduction [Term] id: GO:0002767 name: immune response-inhibiting cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] is_a: GO:0002765 ! immune response-inhibiting signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002768 name: immune response-regulating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002764 ! immune response-regulating signaling pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0002769 name: natural killer cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory KIR signaling pathway" NARROW [] synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] synonym: "natural killer cell inhibitory signalling pathway" EXACT [] synonym: "NK cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002770 name: T cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] synonym: "T cell inhibitory signalling pathway" EXACT [] synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] synonym: "T-cell inhibitory signaling pathway" EXACT [] synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002771 name: inhibitory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] synonym: "KIR signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002772 name: inhibitory C-type lectin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002773 name: B cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] synonym: "B cell inhibitory signalling pathway" EXACT [] synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] synonym: "B-cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002774 name: Fc receptor mediated inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149] synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002777 name: antimicrobial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0043043 ! peptide biosynthetic process relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002778 name: antibacterial peptide production namespace: biological_process def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019731 ! antibacterial humoral response [Term] id: GO:0002779 name: antibacterial peptide secretion namespace: biological_process def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002780 name: antibacterial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002781 name: antifungal peptide production namespace: biological_process def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019732 ! antifungal humoral response [Term] id: GO:0002782 name: antifungal peptide secretion namespace: biological_process def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002783 name: antifungal peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002775 ! antimicrobial peptide production relationship: regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0008348 ! negative regulation of antimicrobial humoral response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002775 ! antimicrobial peptide production relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002786 name: regulation of antibacterial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002778 ! antibacterial peptide production relationship: regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002787 name: negative regulation of antibacterial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "down regulation of antibacterial peptide production" EXACT [] synonym: "down-regulation of antibacterial peptide production" EXACT [] synonym: "downregulation of antibacterial peptide production" EXACT [] synonym: "inhibition of antibacterial peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:1900425 ! negative regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002778 ! antibacterial peptide production relationship: negatively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002788 name: regulation of antifungal peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900150 ! regulation of defense response to fungus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002781 ! antifungal peptide production relationship: regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002789 name: negative regulation of antifungal peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "down regulation of antifungal peptide production" EXACT [] synonym: "down-regulation of antifungal peptide production" EXACT [] synonym: "downregulation of antifungal peptide production" EXACT [] synonym: "inhibition of antifungal peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0031348 ! negative regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002781 ! antifungal peptide production relationship: negatively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002790 ! peptide secretion relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002790 ! peptide secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002790 ! peptide secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002776 ! antimicrobial peptide secretion relationship: regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002776 ! antimicrobial peptide secretion relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002776 ! antimicrobial peptide secretion relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002797 name: regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002779 ! antibacterial peptide secretion relationship: regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002798 name: negative regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "down regulation of antibacterial peptide secretion" EXACT [] synonym: "down-regulation of antibacterial peptide secretion" EXACT [] synonym: "downregulation of antibacterial peptide secretion" EXACT [] synonym: "inhibition of antibacterial peptide secretion" NARROW [] is_a: GO:0002787 ! negative regulation of antibacterial peptide production is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002779 ! antibacterial peptide secretion relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002799 name: positive regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "activation of antibacterial peptide secretion" NARROW [] synonym: "stimulation of antibacterial peptide secretion" NARROW [] synonym: "up regulation of antibacterial peptide secretion" EXACT [] synonym: "up-regulation of antibacterial peptide secretion" EXACT [] synonym: "upregulation of antibacterial peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion is_a: GO:0002803 ! positive regulation of antibacterial peptide production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002779 ! antibacterial peptide secretion relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002800 name: regulation of antifungal peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002782 ! antifungal peptide secretion relationship: regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002801 name: negative regulation of antifungal peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "down regulation of antifungal peptide secretion" EXACT [] synonym: "down-regulation of antifungal peptide secretion" EXACT [] synonym: "downregulation of antifungal peptide secretion" EXACT [] synonym: "inhibition of antifungal peptide secretion" NARROW [] is_a: GO:0002789 ! negative regulation of antifungal peptide production is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002782 ! antifungal peptide secretion relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002802 name: positive regulation of antifungal peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "activation of antifungal peptide secretion" NARROW [] synonym: "stimulation of antifungal peptide secretion" NARROW [] synonym: "up regulation of antifungal peptide secretion" EXACT [] synonym: "up-regulation of antifungal peptide secretion" EXACT [] synonym: "upregulation of antifungal peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion is_a: GO:0002804 ! positive regulation of antifungal peptide production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002782 ! antifungal peptide secretion relationship: positively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002803 name: positive regulation of antibacterial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "activation of antibacterial peptide production" NARROW [] synonym: "stimulation of antibacterial peptide production" NARROW [] synonym: "up regulation of antibacterial peptide production" EXACT [] synonym: "up-regulation of antibacterial peptide production" EXACT [] synonym: "upregulation of antibacterial peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:1900426 ! positive regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002778 ! antibacterial peptide production relationship: positively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002804 name: positive regulation of antifungal peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "activation of antifungal peptide production" NARROW [] synonym: "stimulation of antifungal peptide production" NARROW [] synonym: "up regulation of antifungal peptide production" EXACT [] synonym: "up-regulation of antifungal peptide production" EXACT [] synonym: "upregulation of antifungal peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0031349 ! positive regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002781 ! antifungal peptide production relationship: positively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002805 name: regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002806 name: negative regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002807 name: positive regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002808 name: regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002809 name: negative regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] is_a: GO:0002787 ! negative regulation of antibacterial peptide production is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002810 name: regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002811 name: negative regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] is_a: GO:0002789 ! negative regulation of antifungal peptide production is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002812 name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0002813 name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002814 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002815 name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0002816 name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002817 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002818 name: intracellular defense response namespace: biological_process def: "A physiological defense response which occurs intracellularly." [GOC:add] synonym: "intracellular defence response" EXACT [] is_a: GO:0006968 ! cellular defense response is_a: GO:0033554 ! cellular response to stress intersection_of: GO:0006952 ! defense response intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002250 ! adaptive immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002250 ! adaptive immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002250 ! adaptive immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042088 ! T-helper 1 type immune response relationship: regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042088 ! T-helper 1 type immune response relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042088 ! T-helper 1 type immune response relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042092 ! type 2 immune response relationship: regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002829 name: negative regulation of type 2 immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "down regulation of type 2 immune response" EXACT [] synonym: "down-regulation of type 2 immune response" EXACT [] synonym: "downregulation of type 2 immune response" EXACT [] synonym: "inhibition of type 2 immune response" NARROW [] synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042092 ! type 2 immune response relationship: negatively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "activation of type 2 immune response" NARROW [] synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] synonym: "stimulation of type 2 immune response" NARROW [] synonym: "up regulation of type 2 immune response" EXACT [] synonym: "up-regulation of type 2 immune response" EXACT [] synonym: "upregulation of type 2 immune response" EXACT [] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042092 ! type 2 immune response relationship: positively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009607 ! response to biotic stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002834 name: regulation of response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "regulation of response to tumour cell" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002347 ! response to tumor cell relationship: regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002835 name: negative regulation of response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "down regulation of response to tumor cell" EXACT [] synonym: "down-regulation of response to tumor cell" EXACT [] synonym: "downregulation of response to tumor cell" EXACT [] synonym: "inhibition of response to tumor cell" NARROW [] synonym: "negative regulation of response to tumour cell" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002347 ! response to tumor cell relationship: negatively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002836 name: positive regulation of response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "activation of response to tumor cell" NARROW [] synonym: "positive regulation of response to tumour cell" EXACT [] synonym: "stimulation of response to tumor cell" NARROW [] synonym: "up regulation of response to tumor cell" EXACT [] synonym: "up-regulation of response to tumor cell" EXACT [] synonym: "upregulation of response to tumor cell" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002347 ! response to tumor cell relationship: positively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002837 name: regulation of immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "regulation of immune response to tumour cell" EXACT [] is_a: GO:0002834 ! regulation of response to tumor cell is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002418 ! immune response to tumor cell relationship: regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002838 name: negative regulation of immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "down regulation of immune response to tumor cell" EXACT [] synonym: "down-regulation of immune response to tumor cell" EXACT [] synonym: "downregulation of immune response to tumor cell" EXACT [] synonym: "inhibition of immune response to tumor cell" NARROW [] synonym: "negative regulation of immune response to tumour cell" EXACT [] is_a: GO:0002835 ! negative regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002418 ! immune response to tumor cell relationship: negatively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002839 name: positive regulation of immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "activation of immune response to tumor cell" NARROW [] synonym: "positive regulation of immune response to tumour cell" EXACT [] synonym: "stimulation of immune response to tumor cell" NARROW [] synonym: "up regulation of immune response to tumor cell" EXACT [] synonym: "up-regulation of immune response to tumor cell" EXACT [] synonym: "upregulation of immune response to tumor cell" EXACT [] is_a: GO:0002836 ! positive regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002418 ! immune response to tumor cell relationship: positively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002840 name: regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002841 name: negative regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002842 name: positive regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002843 name: regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002413 ! tolerance induction to tumor cell relationship: regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002844 name: negative regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] synonym: "downregulation of tolerance induction to tumor cell" EXACT [] synonym: "inhibition of tolerance induction to tumor cell" NARROW [] synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002413 ! tolerance induction to tumor cell relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002845 name: positive regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "activation of tolerance induction to tumor cell" NARROW [] synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] synonym: "stimulation of tolerance induction to tumor cell" NARROW [] synonym: "up regulation of tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] synonym: "upregulation of tolerance induction to tumor cell" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002413 ! tolerance induction to tumor cell relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002846 name: regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002847 name: negative regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002848 name: positive regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002458 ! peripheral T cell tolerance induction relationship: regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002458 ! peripheral T cell tolerance induction relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002852 name: regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002853 name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002854 name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002855 name: regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002856 name: negative regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002857 name: positive regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002858 name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002859 name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002860 name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002516 ! B cell deletion relationship: regulates GO:0002516 ! B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002516 ! B cell deletion relationship: negatively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002516 ! B cell deletion relationship: positively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002519 ! natural killer cell tolerance induction relationship: regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002519 ! natural killer cell tolerance induction relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002519 ! natural killer cell tolerance induction relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002874 name: regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002875 name: negative regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002876 name: positive regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002877 name: regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002878 name: negative regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002879 name: positive regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002880 name: regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002881 name: negative regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002882 name: positive regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002524 ! hypersensitivity relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002524 ! hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002524 ! hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016064 ! immunoglobulin mediated immune response relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002445 ! type II hypersensitivity relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002445 ! type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002445 ! type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002895 name: regulation of central B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] is_a: GO:0002646 ! regulation of central tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002510 ! central B cell tolerance induction relationship: regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002896 name: negative regulation of central B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "down regulation of central B cell tolerance induction" EXACT [] synonym: "down-regulation of central B cell tolerance induction" EXACT [] synonym: "downregulation of central B cell tolerance induction" EXACT [] synonym: "inhibition of central B cell tolerance induction" NARROW [] is_a: GO:0002647 ! negative regulation of central tolerance induction is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002510 ! central B cell tolerance induction relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002897 name: positive regulation of central B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "activation of central B cell tolerance induction" NARROW [] synonym: "stimulation of central B cell tolerance induction" NARROW [] synonym: "up regulation of central B cell tolerance induction" EXACT [] synonym: "up-regulation of central B cell tolerance induction" EXACT [] synonym: "upregulation of central B cell tolerance induction" EXACT [] is_a: GO:0002648 ! positive regulation of central tolerance induction is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002510 ! central B cell tolerance induction relationship: positively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002898 name: regulation of central B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002342 ! central B cell deletion relationship: regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002899 name: negative regulation of central B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "down regulation of central B cell deletion" EXACT [] synonym: "down-regulation of central B cell deletion" EXACT [] synonym: "downregulation of central B cell deletion" EXACT [] synonym: "inhibition of central B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002896 ! negative regulation of central B cell tolerance induction is_a: GO:0002898 ! regulation of central B cell deletion is_a: GO:0045578 ! negative regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002342 ! central B cell deletion relationship: negatively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002900 name: positive regulation of central B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "activation of central B cell deletion" NARROW [] synonym: "stimulation of central B cell deletion" NARROW [] synonym: "up regulation of central B cell deletion" EXACT [] synonym: "up-regulation of central B cell deletion" EXACT [] synonym: "upregulation of central B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002897 ! positive regulation of central B cell tolerance induction is_a: GO:0002898 ! regulation of central B cell deletion is_a: GO:0045579 ! positive regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002342 ! central B cell deletion relationship: positively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002901 name: mature B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell apoptosis" NARROW [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptotic process relationship: part_of GO:0001782 ! B cell homeostasis [Term] id: GO:0002902 name: regulation of B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of B cell apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001783 ! B cell apoptotic process relationship: regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002903 name: negative regulation of B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] synonym: "negative regulation of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001783 ! B cell apoptotic process relationship: negatively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002904 name: positive regulation of B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of B cell apoptosis" NARROW [] synonym: "positive regulation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001783 ! B cell apoptotic process relationship: positively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002901 ! mature B cell apoptotic process relationship: regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002906 name: negative regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] synonym: "negative regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002901 ! mature B cell apoptotic process relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002907 name: positive regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "positive regulation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002901 ! mature B cell apoptotic process relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002908 name: regulation of peripheral B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002867 ! regulation of B cell deletion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002454 ! peripheral B cell deletion relationship: regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002909 name: negative regulation of peripheral B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "down regulation of peripheral B cell deletion" EXACT [] synonym: "down-regulation of peripheral B cell deletion" EXACT [] synonym: "downregulation of peripheral B cell deletion" EXACT [] synonym: "inhibition of peripheral B cell deletion" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002454 ! peripheral B cell deletion relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002910 name: positive regulation of peripheral B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "activation of peripheral B cell deletion" NARROW [] synonym: "stimulation of peripheral B cell deletion" NARROW [] synonym: "up regulation of peripheral B cell deletion" EXACT [] synonym: "up-regulation of peripheral B cell deletion" EXACT [] synonym: "upregulation of peripheral B cell deletion" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002454 ! peripheral B cell deletion relationship: positively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002249 ! lymphocyte anergy relationship: regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002249 ! lymphocyte anergy relationship: negatively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002249 ! lymphocyte anergy relationship: positively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002914 name: regulation of central B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002341 ! central B cell anergy relationship: regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002915 name: negative regulation of central B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "down regulation of central B cell anergy" EXACT [] synonym: "down-regulation of central B cell anergy" EXACT [] synonym: "downregulation of central B cell anergy" EXACT [] synonym: "inhibition of central B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002896 ! negative regulation of central B cell tolerance induction is_a: GO:0002914 ! regulation of central B cell anergy is_a: GO:0045578 ! negative regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002341 ! central B cell anergy relationship: negatively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002916 name: positive regulation of central B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "activation of central B cell anergy" NARROW [] synonym: "stimulation of central B cell anergy" NARROW [] synonym: "up regulation of central B cell anergy" EXACT [] synonym: "up-regulation of central B cell anergy" EXACT [] synonym: "upregulation of central B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002897 ! positive regulation of central B cell tolerance induction is_a: GO:0002914 ! regulation of central B cell anergy is_a: GO:0045579 ! positive regulation of B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002341 ! central B cell anergy relationship: positively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002917 name: regulation of peripheral B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002453 ! peripheral B cell anergy relationship: regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002918 name: negative regulation of peripheral B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "down regulation of peripheral B cell anergy" EXACT [] synonym: "down-regulation of peripheral B cell anergy" EXACT [] synonym: "downregulation of peripheral B cell anergy" EXACT [] synonym: "inhibition of peripheral B cell anergy" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002917 ! regulation of peripheral B cell anergy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002453 ! peripheral B cell anergy relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002919 name: positive regulation of peripheral B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "activation of peripheral B cell anergy" NARROW [] synonym: "stimulation of peripheral B cell anergy" NARROW [] synonym: "up regulation of peripheral B cell anergy" EXACT [] synonym: "up-regulation of peripheral B cell anergy" EXACT [] synonym: "upregulation of peripheral B cell anergy" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002917 ! regulation of peripheral B cell anergy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002453 ! peripheral B cell anergy relationship: positively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006959 ! humoral immune response relationship: regulates GO:0006959 ! humoral immune response [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006959 ! humoral immune response relationship: negatively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006959 ! humoral immune response relationship: positively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002923 name: regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0002920 ! regulation of humoral immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002924 name: negative regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002925 name: positive regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002926 name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation namespace: biological_process def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988] synonym: "mcm5 modification" EXACT [] synonym: "mcm5s2U34 biosynthesis" EXACT [] synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification created_by: hjd creation_date: 2012-01-17T02:50:54Z [Term] id: GO:0002927 name: archaeosine-tRNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393] comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. is_a: GO:0006400 ! tRNA modification is_a: GO:0009058 ! biosynthetic process relationship: has_part GO:0002948 ! archaeosine synthase activity relationship: has_part GO:0043867 ! 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity created_by: hjd creation_date: 2012-01-18T03:06:27Z [Term] id: GO:0002929 name: MECO complex namespace: cellular_component def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642] synonym: "meta-coactivator complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0005671 ! Ada2/Gcn5/Ada3 transcription activator complex relationship: has_part GO:0016592 ! mediator complex created_by: hjd creation_date: 2012-03-14T02:50:13Z [Term] id: GO:0002930 name: trabecular meshwork development namespace: biological_process def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247] is_a: GO:0009888 ! tissue development relationship: part_of GO:0043010 ! camera-type eye development created_by: hjd creation_date: 2012-04-19T04:50:06Z [Term] id: GO:0002931 name: response to ischemia namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd] comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia. is_a: GO:0006950 ! response to stress created_by: hjd creation_date: 2012-04-20T02:57:51Z [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0035989 ! tendon development created_by: hjd creation_date: 2012-04-23T02:11:22Z [Term] id: GO:0002933 name: lipid hydroxylation namespace: biological_process def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937] synonym: "fatty acid hydroxylation" RELATED [] is_a: GO:0030258 ! lipid modification created_by: hjd creation_date: 2012-04-24T02:26:33Z [Term] id: GO:0002934 name: desmosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] is_a: GO:0045216 ! cell-cell junction organization created_by: hjd creation_date: 2012-05-08T02:59:08Z [Term] id: GO:0002935 name: tRNA (adenine-C2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity created_by: hjd creation_date: 2012-09-04T14:39:56Z [Term] id: GO:0002936 name: bradykinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043043 ! peptide biosynthetic process created_by: hjd creation_date: 2012-10-17T14:24:24Z [Term] id: GO:0002937 name: tRNA 4-thiouridine biosynthesis namespace: biological_process def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X] comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to an unidentified intermediate. NuvC also participates in thiamine synthesis. is_a: GO:0034227 ! tRNA thio-modification created_by: hjd creation_date: 2012-10-19T15:26:28Z [Term] id: GO:0002938 name: tRNA guanine ribose methylation namespace: biological_process def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:1555811337] is_a: GO:0002128 ! tRNA nucleoside ribose methylation created_by: hjd creation_date: 2012-11-02T15:55:55Z [Term] id: GO:0002939 name: tRNA N1-guanine methylation namespace: biological_process def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m1-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation created_by: hjd creation_date: 2012-11-09T16:18:41Z [Term] id: GO:0002940 name: tRNA N2-guanine methylation namespace: biological_process def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m2-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation created_by: hjd creation_date: 2012-11-09T16:23:41Z [Term] id: GO:0002941 name: synoviocyte proliferation namespace: biological_process def: "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370] is_a: GO:0008283 ! cell population proliferation created_by: hjd creation_date: 2012-11-16T14:25:45Z [Term] id: GO:0002942 name: tRNA m2,2-guanine biosynthesis namespace: biological_process def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation created_by: hjd creation_date: 2012-11-16T16:07:20Z [Term] id: GO:0002943 name: tRNA dihydrouridine synthesis namespace: biological_process def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:155581073X] comment: Dihydrouridine is found in numerous positions within loop I, the so-called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b. is_a: GO:0006400 ! tRNA modification created_by: hjd creation_date: 2012-11-16T16:20:37Z [Term] id: GO:0002944 name: cyclin K-CDK12 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk12 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: hjd creation_date: 2012-12-05T16:09:48Z [Term] id: GO:0002945 name: cyclin K-CDK13 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk13 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: hjd creation_date: 2012-12-05T16:13:28Z [Term] id: GO:0002946 name: tRNA C5-cytosine methylation namespace: biological_process def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:155581073X] synonym: "tRNA 5-methylcytosine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation created_by: hjd creation_date: 2012-12-07T14:23:13Z [Term] id: GO:0002947 name: tumor necrosis factor receptor superfamily complex namespace: cellular_component def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc] synonym: "TNF receptor superfamily complex" RELATED [] is_a: GO:0043235 ! receptor complex created_by: hjd creation_date: 2012-12-20T13:26:39Z [Term] id: GO:0002948 name: archaeosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, Wikipedia:Archaeosine_synthase] synonym: "ArcS" RELATED [] synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED [] xref: EC:2.6.1.97 is_a: GO:0015067 ! amidinotransferase activity created_by: hjd creation_date: 2014-08-11T10:33:59Z [Term] id: GO:0002949 name: tRNA threonylcarbamoyladenosine modification namespace: biological_process alt_id: GO:0070526 def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706] synonym: "t6A biosynthesis" EXACT [PMID:19287007] synonym: "t6A biosynthetic process" EXACT [PMID:19287007] synonym: "t6A tRNA modification" EXACT [] synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT [] synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah] is_a: GO:0006400 ! tRNA modification is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process created_by: hjd creation_date: 2014-09-19T10:15:27Z [Term] id: GO:0002950 name: ceramide phosphoethanolamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine." [EC:2.7.8.n3, PMID:25667419] xref: Reactome:R-HSA-8959462 "SAMD8 transforms PE and CERA to CPE" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups created_by: hjd creation_date: 2016-08-16T13:41:21Z [Term] id: GO:0002951 name: leukotriene-C(4) hydrolase namespace: molecular_function def: "Catalysis of the reaction Leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate." [EC:3.4.19.14, PMID:9774450] comment: The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione. is_a: GO:0070122 ! isopeptidase activity [Term] id: GO:0002952 name: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity namespace: molecular_function def: "Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione." [EC:5.3.1.32] synonym: "phospho-AI-2 isomerase activity" RELATED [] is_a: GO:0016853 ! isomerase activity [Term] id: GO:0002953 name: 5'-deoxynucleotidase activity namespace: molecular_function def: "Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate." [EC:3.1.3.89] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003001 name: obsolete generation of a signal involved in cell-cell signaling namespace: biological_process def: "OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] comment: This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling. synonym: "formation of a signal" BROAD [] synonym: "generation of a signal involved in cell-cell signaling" EXACT [] synonym: "generation of a signal involved in cell-cell signalling" EXACT [] synonym: "signal generation" BROAD [] is_obsolete: true consider: GO:0007267 consider: GO:0010496 consider: GO:0023061 consider: GO:0031130 [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003003 name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage namespace: biological_process def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: part_of GO:0048165 ! fused antrum stage relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0003004 name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: part_of GO:0048164 ! distinct antral spaces stage relationship: part_of GO:0048164 ! distinct antral spaces stage [Term] id: GO:0003005 name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum intersection_of: part_of GO:0048163 ! scattered antral spaces stage relationship: part_of GO:0048163 ! scattered antral spaces stage [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0000003 ! reproduction [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003010 name: voluntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003011 name: involuntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "respiratory gaseous exchange" EXACT [] is_a: GO:0003008 ! system process relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system [Term] id: GO:0003017 name: lymph circulation namespace: biological_process def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003019 name: central nervous system control of baroreceptor feedback namespace: biological_process def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0003020 name: detection of reduced oxygen by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0070483 ! detection of hypoxia relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003021 name: detection of increased carbon dioxide by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003022 name: detection of pH by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003030 ! detection of hydrogen ion [Term] id: GO:0003023 name: baroreceptor detection of increased arterial stretch namespace: biological_process def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0003024 name: baroreceptor detection of decreased arterial stretch namespace: biological_process def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0003025 name: regulation of systemic arterial blood pressure by baroreceptor feedback namespace: biological_process def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003026 name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0003027 name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] synonym: "vagal reflex" BROAD [] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003028 name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003029 name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003030 name: detection of hydrogen ion namespace: biological_process def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003031 name: detection of carbon dioxide namespace: biological_process def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003033 name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003034 name: detection of increased carbon dioxide by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003035 name: detection of increased carbon dioxide by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003036 name: detection of pH by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003037 name: detection of pH by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003038 name: detection of reduced oxygen by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003039 name: detection of reduced oxygen by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003040 name: excitation of vasomotor center by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003041 name: excitation of vasomotor center by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003042 name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951] synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003043 name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003045 name: regulation of systemic arterial blood pressure by physical factors namespace: biological_process def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by physical factors" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003046 name: regulation of systemic arterial blood pressure by stress relaxation namespace: biological_process def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by stress relaxation" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003047 name: regulation of systemic arterial blood pressure by epinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by epinephrine" RELATED [] synonym: "regulation of blood pressure by adrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003048 name: regulation of systemic arterial blood pressure by norepinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by norepinephrine" RELATED [] synonym: "regulation of blood pressure by noradrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003049 name: regulation of systemic arterial blood pressure by capillary fluid shift namespace: biological_process def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by capillary fluid shift" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors [Term] id: GO:0003050 name: regulation of systemic arterial blood pressure by atrial natriuretic peptide namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003051 name: angiotensin-mediated drinking behavior namespace: biological_process def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] is_a: GO:0042756 ! drinking behavior relationship: part_of GO:0002035 ! brain renin-angiotensin system [Term] id: GO:0003052 name: circadian regulation of systemic arterial blood pressure namespace: biological_process def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003053 name: circadian regulation of heart rate namespace: biological_process def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate" RELATED [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0007623 ! circadian rhythm is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003054 name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "master pacemaker clock regulation of blood pressure" EXACT [] synonym: "SCN regulation of blood pressure" EXACT [] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003055 name: circadian regulation of heart rate by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] synonym: "master pacemaker clock regulation of heart rate" EXACT [] synonym: "SCN regulation of heart rate" EXACT [] is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 name: regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction relationship: regulates GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0003057 name: regulation of the force of heart contraction by chemical signal namespace: biological_process def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] synonym: "chemical cardiac inotropy" EXACT [] synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0003058 name: hormonal regulation of the force of heart contraction namespace: biological_process def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac inotropy" EXACT [] synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal [Term] id: GO:0003059 name: positive regulation of the force of heart contraction by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac inotropy" EXACT [] synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac inotropy" EXACT [] synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003060 name: negative regulation of the force of heart contraction by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "decreased force of heart contraction by acetylcholine" EXACT [] is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003061 name: positive regulation of the force of heart contraction by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] synonym: "increased force of heart contraction by adrenaline" RELATED [] synonym: "increased force of heart contraction by norepinephrine" EXACT [] synonym: "noradrenaline cardiac inotropy" EXACT [] synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac inotropy" EXACT [] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003062 name: regulation of heart rate by chemical signal namespace: biological_process def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] synonym: "chemical cardiac chronotropy" EXACT [] synonym: "chemical signal regulation of heart contraction rate" RELATED [] synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate [Term] id: GO:0003063 name: negative regulation of heart rate by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003064 name: regulation of heart rate by hormone namespace: biological_process def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac chronotropy" EXACT [] synonym: "regulation of the rate of heart contraction by hormone" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal [Term] id: GO:0003065 name: positive regulation of heart rate by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac chronotropy" EXACT [] synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003066 name: positive regulation of heart rate by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "noradrenaline cardiac chronotropy" EXACT [] synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003067 name: circadian regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003068 name: regulation of systemic arterial blood pressure by acetylcholine namespace: biological_process def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] synonym: "blood pressure regulation by acetylcholine" EXACT [] is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter [Term] id: GO:0003069 name: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] synonym: "vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003070 name: regulation of systemic arterial blood pressure by neurotransmitter namespace: biological_process def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio] is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process intersection_of: GO:0003014 ! renal system process intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003072 name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003074 name: obsolete regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035809 [Term] id: GO:0003075 name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [Term] id: GO:0003077 name: obsolete negative regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "negative regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035811 [Term] id: GO:0003078 name: obsolete regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. synonym: "regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035813 [Term] id: GO:0003079 name: obsolete positive regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035815 [Term] id: GO:0003080 name: obsolete negative regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. synonym: "negative regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035814 [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003082 name: obsolete positive regulation of renal output by angiotensin namespace: biological_process def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of renal output by angiotensin" EXACT [] is_obsolete: true [Term] id: GO:0003083 name: negative regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0003084 name: positive regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045777 ! positive regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003085 name: negative regulation of systemic arterial blood pressure namespace: biological_process def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045776 ! negative regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003086 name: regulation of systemic arterial blood pressure by local renal renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0003087 name: positive regulation of the force of heart contraction by neuronal epinephrine namespace: biological_process def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine [Term] id: GO:0003088 name: positive regulation of the force of heart contraction by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine [Term] id: GO:0003089 name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003090 name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] synonym: "water homeostasis by the renal system" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0003092 name: renal water retention namespace: biological_process def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio] synonym: "negative regulation of renal water excretion" EXACT [] is_a: GO:0035811 ! negative regulation of urine volume [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003094 ! glomerular filtration relationship: regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] is_a: GO:0097205 ! renal filtration [Term] id: GO:0003095 name: pressure natriuresis namespace: biological_process def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the renal system." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport relationship: part_of GO:0003091 ! renal water homeostasis [Term] id: GO:0003098 name: tubuloglomerular feedback namespace: biological_process def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] xref: Wikipedia:Tubuloglomerular_feedback is_a: GO:0001977 ! renal system process involved in regulation of blood volume relationship: part_of GO:0003093 ! regulation of glomerular filtration [Term] id: GO:0003099 name: positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0003100 name: regulation of systemic arterial blood pressure by endothelin namespace: biological_process def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003101 name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine namespace: biological_process def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003102 name: obsolete positive regulation of diuresis by angiotensin namespace: biological_process def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of diuresis by angiotensin" EXACT [] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003103 name: obsolete positive regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003094 ! glomerular filtration relationship: positively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003094 ! glomerular filtration relationship: negatively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003106 name: negative regulation of glomerular filtration by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb] synonym: "regulation of glomerular filtration by angiotensin" BROAD [] is_a: GO:0003083 ! negative regulation of renal output by angiotensin relationship: part_of GO:0003105 ! negative regulation of glomerular filtration [Term] id: GO:0003107 name: obsolete positive regulation of natriuresis by angiotensin namespace: biological_process def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of natriuresis by angiotensin" EXACT [] is_obsolete: true [Term] id: GO:0003108 name: negative regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0003109 name: positive regulation of the force of heart contraction by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003110 name: positive regulation of the force of heart contraction by neuronal norepinephrine namespace: biological_process def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003111 name: positive regulation of heart rate by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003112 name: positive regulation of heart rate by neuronal epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003113 name: positive regulation of heart rate by neuronal norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003114 name: positive regulation of heart rate by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003115 name: regulation of vasoconstriction by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003116 name: regulation of vasoconstriction by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003117 name: regulation of vasoconstriction by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003118 name: regulation of vasoconstriction by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003119 name: regulation of vasoconstriction by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003120 name: regulation of vasoconstriction by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003121 name: epinephrine-mediated vasodilation namespace: biological_process alt_id: GO:0003123 alt_id: GO:0003124 def: "A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by adrenaline" RELATED [] synonym: "regulation of vasodilation by circulating adrenaline" RELATED [] synonym: "regulation of vasodilation by circulating epinephrine" RELATED [] synonym: "regulation of vasodilation by epinephrine" RELATED [] synonym: "regulation of vasodilation by neuronal adrenaline" RELATED [] synonym: "regulation of vasodilation by neuronal epinephrine" RELATED [] is_a: GO:0042311 ! vasodilation [Term] id: GO:0003122 name: norepinephrine-mediated vasodilation namespace: biological_process alt_id: GO:0003125 alt_id: GO:0003126 def: "A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating noradrenaline" RELATED [] synonym: "regulation of vasodilation by circulating norepinephrine" RELATED [] synonym: "regulation of vasodilation by neuronal noradrenaline" RELATED [] synonym: "regulation of vasodilation by neuronal norepinephrine" RELATED [] synonym: "regulation of vasodilation by noradrenaline" RELATED [] synonym: "regulation of vasodilation by norepinephrine" RELATED [] is_a: GO:0042311 ! vasodilation [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: tanyaberardini creation_date: 2009-09-22T02:45:48Z [Term] id: GO:0003128 name: heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart] is_a: GO:0010092 ! specification of animal organ identity relationship: part_of GO:0060914 ! heart formation created_by: tanyaberardini creation_date: 2009-09-22T02:56:05Z [Term] id: GO:0003129 name: heart induction namespace: biological_process def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] is_a: GO:0001759 ! organ induction is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0001759 ! organ induction intersection_of: positively_regulates GO:0003128 ! heart field specification relationship: positively_regulates GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T02:58:41Z [Term] id: GO:0003130 name: BMP signaling pathway involved in heart induction namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0003129 ! heart induction relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:02:00Z [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling created_by: tanyaberardini creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003132 name: mesodermal-endodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003131 ! mesodermal-endodermal cell signaling intersection_of: GO:0003131 ! mesodermal-endodermal cell signaling intersection_of: part_of GO:0003129 ! heart induction relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:08:52Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling created_by: tanyaberardini creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003134 name: endodermal-mesodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003133 ! endodermal-mesodermal cell signaling intersection_of: GO:0003133 ! endodermal-mesodermal cell signaling intersection_of: part_of GO:0003129 ! heart induction relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:11:17Z [Term] id: GO:0003135 name: fibroblast growth factor receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0003129 ! heart induction relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:17:49Z [Term] id: GO:0003136 name: negative regulation of heart induction by canonical Wnt signaling pathway namespace: biological_process def: "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of heart induction by canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of heart induction by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development is_a: GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway is_a: GO:1901320 ! negative regulation of heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:26:17Z [Term] id: GO:0003137 name: Notch signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0003129 ! heart induction relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:28:42Z [Term] id: GO:0003138 name: primary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "FHS specification" EXACT [GOC:rl] synonym: "first heart field specification" EXACT [GOC:rl] is_a: GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T03:47:24Z [Term] id: GO:0003139 name: secondary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708] synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840] is_a: GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T03:47:56Z [Term] id: GO:0003140 name: determination of left/right asymmetry in lateral mesoderm namespace: biological_process def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048368 ! lateral mesoderm development created_by: tanyaberardini creation_date: 2009-09-22T03:58:29Z [Term] id: GO:0003141 name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_obsolete: true replaced_by: GO:1900164 created_by: tanyaberardini creation_date: 2009-09-22T04:03:22Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development relationship: part_of GO:0048562 ! embryonic organ morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation created_by: tanyaberardini creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003146 name: heart jogging namespace: biological_process def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] synonym: "cardiac jogging" EXACT [GOC:mtg_heart] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry created_by: tanyaberardini creation_date: 2009-09-22T06:11:41Z [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0001755 ! neural crest cell migration intersection_of: part_of GO:0060914 ! heart formation relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development created_by: tanyaberardini creation_date: 2009-09-22T04:29:55Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: part_of GO:0003144 ! embryonic heart tube formation relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tanyaberardini creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003153 name: closure of embryonic heart tube namespace: biological_process def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] is_a: GO:0060606 ! tube closure relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tanyaberardini creation_date: 2009-09-23T10:14:54Z [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling] synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0007368 ! determination of left/right symmetry created_by: tanyaberardini creation_date: 2009-09-24T05:34:57Z [Term] id: GO:0003155 name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm created_by: tanyaberardini creation_date: 2009-09-24T05:42:17Z [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048645 ! animal organ formation relationship: regulates GO:0048645 ! animal organ formation created_by: tanyaberardini creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development created_by: dph creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0003158 ! endothelium development created_by: dph creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development created_by: dph creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003164 ! His-Purkinje system development created_by: dph creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003164 ! His-Purkinje system development created_by: dph creation_date: 2009-10-01T02:08:43Z [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003166 ! bundle of His development created_by: dph creation_date: 2009-10-01T02:48:23Z [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003165 ! Purkinje myocyte development created_by: dph creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-08T10:50:09Z [Term] id: GO:0003171 name: atrioventricular valve development namespace: biological_process def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "AV valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:14:21Z [Term] id: GO:0003172 name: sinoatrial valve development namespace: biological_process def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "SA valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:15:39Z [Term] id: GO:0003173 name: ventriculo bulbo valve development namespace: biological_process def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:16:25Z [Term] id: GO:0003174 name: mitral valve development namespace: biological_process def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003171 ! atrioventricular valve development created_by: dph creation_date: 2009-10-08T11:17:22Z [Term] id: GO:0003175 name: tricuspid valve development namespace: biological_process def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003171 ! atrioventricular valve development created_by: dph creation_date: 2009-10-08T11:18:12Z [Term] id: GO:0003176 name: aortic valve development namespace: biological_process def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:1905314 ! semi-lunar valve development created_by: dph creation_date: 2009-10-08T11:18:55Z [Term] id: GO:0003177 name: pulmonary valve development namespace: biological_process def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:1905314 ! semi-lunar valve development created_by: dph creation_date: 2009-10-08T11:19:44Z [Term] id: GO:0003178 name: coronary sinus valve development namespace: biological_process def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:21:43Z [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf] synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:23:48Z [Term] id: GO:0003180 name: aortic valve morphogenesis namespace: biological_process def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003176 ! aortic valve development created_by: dph creation_date: 2009-10-08T11:29:42Z [Term] id: GO:0003181 name: atrioventricular valve morphogenesis namespace: biological_process def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart] synonym: "AV valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003171 ! atrioventricular valve development created_by: dph creation_date: 2009-10-08T11:31:59Z [Term] id: GO:0003182 name: coronary sinus valve morphogenesis namespace: biological_process def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003178 ! coronary sinus valve development created_by: dph creation_date: 2009-10-08T11:33:31Z [Term] id: GO:0003183 name: mitral valve morphogenesis namespace: biological_process def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003181 ! atrioventricular valve morphogenesis relationship: part_of GO:0003174 ! mitral valve development created_by: dph creation_date: 2009-10-08T12:02:01Z [Term] id: GO:0003184 name: pulmonary valve morphogenesis namespace: biological_process def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003177 ! pulmonary valve development created_by: dph creation_date: 2009-10-08T12:03:35Z [Term] id: GO:0003185 name: sinoatrial valve morphogenesis namespace: biological_process def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart] synonym: "SA valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003172 ! sinoatrial valve development created_by: dph creation_date: 2009-10-08T12:04:52Z [Term] id: GO:0003186 name: tricuspid valve morphogenesis namespace: biological_process def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003181 ! atrioventricular valve morphogenesis relationship: part_of GO:0003175 ! tricuspid valve development created_by: dph creation_date: 2009-10-08T12:05:45Z [Term] id: GO:0003187 name: ventriculo bulbo valve morphogenesis namespace: biological_process def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003173 ! ventriculo bulbo valve development created_by: dph creation_date: 2009-10-08T12:07:00Z [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-08T12:20:15Z [Term] id: GO:0003189 name: aortic valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003180 ! aortic valve morphogenesis created_by: dph creation_date: 2009-10-08T01:05:44Z [Term] id: GO:0003190 name: atrioventricular valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "AV valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis created_by: dph creation_date: 2009-10-08T01:07:28Z [Term] id: GO:0003191 name: coronary sinus valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis created_by: dph creation_date: 2009-10-08T01:09:04Z [Term] id: GO:0003192 name: mitral valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003190 ! atrioventricular valve formation relationship: part_of GO:0003183 ! mitral valve morphogenesis created_by: dph creation_date: 2009-10-08T01:10:19Z [Term] id: GO:0003193 name: pulmonary valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003184 ! pulmonary valve morphogenesis created_by: dph creation_date: 2009-10-08T01:11:20Z [Term] id: GO:0003194 name: sinoatrial valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "SA valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis created_by: dph creation_date: 2009-10-08T01:12:45Z [Term] id: GO:0003195 name: tricuspid valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003190 ! atrioventricular valve formation relationship: part_of GO:0003186 ! tricuspid valve morphogenesis created_by: dph creation_date: 2009-10-08T01:14:40Z [Term] id: GO:0003196 name: ventriculo bulbo valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis created_by: dph creation_date: 2009-10-08T01:16:02Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003198 name: epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: part_of GO:0003272 ! endocardial cushion formation relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-08T01:27:42Z [Term] id: GO:0003199 name: endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: part_of GO:0003188 ! heart valve formation relationship: part_of GO:0003188 ! heart valve formation created_by: dph creation_date: 2009-10-08T01:31:21Z [Term] id: GO:0003200 name: endocardial cushion to mesenchymal transition involved in heart chamber septation namespace: biological_process def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: part_of GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0060411 ! cardiac septum morphogenesis created_by: dph creation_date: 2009-10-08T01:34:31Z [Term] id: GO:0003201 name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-08T01:36:54Z [Term] id: GO:0003202 name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: GO:0090500 ! endocardial cushion to mesenchymal transition intersection_of: part_of GO:0003204 ! cardiac skeleton development relationship: part_of GO:0003204 ! cardiac skeleton development created_by: dph creation_date: 2009-10-08T01:39:57Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development created_by: dph creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis created_by: dph creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003231 ! cardiac ventricle development created_by: dph creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003230 ! cardiac atrium development created_by: dph creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis created_by: dph creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis created_by: dph creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis created_by: dph creation_date: 2009-10-13T10:33:00Z [Term] id: GO:0003223 name: ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T10:34:21Z [Term] id: GO:0003224 name: left ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:43:36Z [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:45:09Z [Term] id: GO:0003226 name: right ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:48:42Z [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:50:59Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development created_by: dph creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003232 name: bulbus arteriosus development namespace: biological_process def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:05:36Z [Term] id: GO:0003233 name: bulbus arteriosus morphogenesis namespace: biological_process def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003232 ! bulbus arteriosus development created_by: dph creation_date: 2009-10-13T11:07:30Z [Term] id: GO:0003234 name: bulbus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis created_by: dph creation_date: 2009-10-13T11:10:02Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003235 ! sinus venosus development created_by: dph creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003236 ! sinus venosus morphogenesis created_by: dph creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003238 name: conus arteriosus development namespace: biological_process def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:20:57Z [Term] id: GO:0003239 name: conus arteriosus morphogenesis namespace: biological_process def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003238 ! conus arteriosus development created_by: dph creation_date: 2009-10-13T11:25:04Z [Term] id: GO:0003240 name: conus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003239 ! conus arteriosus morphogenesis created_by: dph creation_date: 2009-10-13T11:25:47Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth created_by: dph creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003242 name: cardiac chamber ballooning namespace: biological_process def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis created_by: dph creation_date: 2009-10-13T11:30:30Z [Term] id: GO:0003243 name: circumferential growth involved in left ventricle morphogenesis namespace: biological_process def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis created_by: dph creation_date: 2009-10-13T11:33:09Z [Term] id: GO:0003244 name: radial growth involved in right ventricle morphogenesis namespace: biological_process def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis created_by: dph creation_date: 2009-10-13T11:38:23Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003246 name: embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis created_by: dph creation_date: 2009-10-13T11:46:23Z [Term] id: GO:0003247 name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis created_by: dph creation_date: 2009-10-13T11:50:29Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development created_by: dph creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis is_a: GO:2000793 ! cell proliferation involved in heart valve development intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-13T01:59:19Z [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:03:42Z [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:07:20Z [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:10:39Z [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis created_by: dph creation_date: 2009-10-13T02:14:16Z [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050794 ! regulation of cellular process is_a: GO:0050801 ! ion homeostasis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051899 ! membrane depolarization relationship: regulates GO:0051899 ! membrane depolarization created_by: tanyaberardini creation_date: 2009-10-14T10:54:09Z [Term] id: GO:0003255 name: endocardial precursor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation created_by: dph creation_date: 2009-10-15T12:09:43Z [Term] id: GO:0003256 name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: dph creation_date: 2009-10-15T01:01:25Z [Term] id: GO:0003257 name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation is_a: GO:1901228 ! positive regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: dph creation_date: 2009-10-15T01:07:25Z [Term] id: GO:0003258 name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0003255 ! endocardial precursor cell differentiation relationship: part_of GO:0003255 ! endocardial precursor cell differentiation created_by: dph creation_date: 2009-10-15T01:10:34Z [Term] id: GO:0003259 name: cardioblast anterior-lateral migration namespace: biological_process def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration created_by: dph creation_date: 2009-10-15T01:17:28Z [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation created_by: dph creation_date: 2009-10-15T01:52:25Z [Term] id: GO:0003261 name: cardiac muscle progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation created_by: dph creation_date: 2009-10-15T01:57:55Z [Term] id: GO:0003262 name: endocardial progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation created_by: dph creation_date: 2009-10-15T02:00:41Z [Term] id: GO:0003263 name: cardioblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0060914 ! heart formation created_by: dph creation_date: 2009-10-15T02:13:05Z [Term] id: GO:0003264 name: regulation of cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003263 ! cardioblast proliferation relationship: regulates GO:0003263 ! cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:19:37Z [Term] id: GO:0003265 name: regulation of primary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl] synonym: "regulation of first heart field cardiac proliferation" RELATED [] synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:25:26Z [Term] id: GO:0003266 name: regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "regulation of SHF cardioblast proliferation" EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:26:15Z [Term] id: GO:0003267 name: canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" RELATED [GOC:signaling] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:36:08Z [Term] id: GO:0003268 name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development intersection_of: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:43:03Z [Term] id: GO:0003269 name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061312 ! BMP signaling pathway involved in heart development intersection_of: GO:0061312 ! BMP signaling pathway involved in heart development intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:45:28Z [Term] id: GO:0003270 name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph] synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:47:00Z [Term] id: GO:0003271 name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf] synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:48:32Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0003272 ! endocardial cushion formation relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:26:32Z [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003276 name: apoptotic process involved in heart valve morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart valve morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-20T09:34:29Z [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003231 ! cardiac ventricle development created_by: dph creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003282 name: ventricular septum intermedium development namespace: biological_process def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003281 ! ventricular septum development created_by: dph creation_date: 2009-10-20T10:09:53Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003230 ! cardiac atrium development created_by: dph creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003284 name: septum primum development namespace: biological_process def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:12:26Z [Term] id: GO:0003285 name: septum secundum development namespace: biological_process def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:21:13Z [Term] id: GO:0003286 name: atrial septum intermedium development namespace: biological_process def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:23:52Z [Term] id: GO:0003288 name: ventricular septum intermedium morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060412 ! ventricular septum morphogenesis created_by: dph creation_date: 2009-10-20T10:58:48Z [Term] id: GO:0003289 name: atrial septum primum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003284 ! septum primum development created_by: dph creation_date: 2009-10-20T10:32:32Z [Term] id: GO:0003290 name: atrial septum secundum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003285 ! septum secundum development created_by: dph creation_date: 2009-10-20T10:33:57Z [Term] id: GO:0003291 name: atrial septum intermedium morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003286 ! atrial septum intermedium development created_by: dph creation_date: 2009-10-20T10:35:04Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003279 ! cardiac septum development created_by: dph creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-20T11:06:46Z [Term] id: GO:0003294 name: atrial ventricular junction remodeling namespace: biological_process def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart] synonym: "atrio-ventricular junction remodeling" RELATED [GOC:mtg_heart] synonym: "atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-22T08:35:36Z [Term] id: GO:0003295 name: cell proliferation involved in atrial ventricular junction remodeling namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "cell proliferation involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling relationship: part_of GO:0003294 ! atrial ventricular junction remodeling created_by: dph creation_date: 2009-10-22T08:38:30Z [Term] id: GO:0003296 name: apoptotic process involved in atrial ventricular junction remodeling namespace: biological_process def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW [] synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "apoptosis involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling relationship: part_of GO:0003294 ! atrial ventricular junction remodeling created_by: dph creation_date: 2009-10-22T08:43:11Z [Term] id: GO:0003297 name: heart wedging namespace: biological_process def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-22T08:52:58Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy created_by: dph creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003299 name: muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] is_a: GO:0006950 ! response to stress is_a: GO:0014896 ! muscle hypertrophy is_a: GO:0043500 ! muscle adaptation created_by: dph creation_date: 2009-10-22T09:26:10Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy created_by: dph creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth created_by: dph creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003302 name: transforming growth factor beta receptor signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling] synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry is_a: GO:1905313 ! transforming growth factor beta receptor signaling pathway involved in heart development intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0003146 ! heart jogging relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T10:51:58Z [Term] id: GO:0003303 name: BMP signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry is_a: GO:0061312 ! BMP signaling pathway involved in heart development intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0003146 ! heart jogging relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:00:58Z [Term] id: GO:0003304 name: myocardial epithelial involution involved in heart jogging namespace: biological_process def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:03:33Z [Term] id: GO:0003305 name: cell migration involved in heart jogging namespace: biological_process def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0003146 ! heart jogging relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:05:46Z [Term] id: GO:0003306 name: Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-22T12:26:07Z [Term] id: GO:0003307 name: regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003306 ! Wnt signaling pathway involved in heart development relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:32:10Z [Term] id: GO:0003308 name: negative regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:36:11Z [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:28:05Z [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:30:27Z [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:32:32Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0035050 ! embryonic heart tube development created_by: dph creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0003313 ! heart rudiment development created_by: dph creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003314 ! heart rudiment morphogenesis created_by: dph creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003316 name: establishment of myocardial progenitor cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:01:26Z [Term] id: GO:0003317 name: cardioblast cell midline fusion namespace: biological_process def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] is_a: GO:0034109 ! homotypic cell-cell adhesion relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:08:57Z [Term] id: GO:0003318 name: cell migration to the midline involved in heart development namespace: biological_process def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development created_by: dph creation_date: 2009-10-27T09:15:43Z [Term] id: GO:0003319 name: cardioblast migration to the midline involved in heart rudiment formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:21:36Z [Term] id: GO:0003320 name: heart rudiment involution namespace: biological_process def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation created_by: dph creation_date: 2009-10-27T09:29:24Z [Term] id: GO:0003321 name: positive regulation of blood pressure by epinephrine-norepinephrine namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine is_a: GO:0045777 ! positive regulation of blood pressure created_by: dph creation_date: 2009-10-29T01:52:50Z [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003310 ! pancreatic A cell differentiation created_by: dph creation_date: 2009-11-02T08:13:55Z [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003309 ! type B pancreatic cell differentiation created_by: dph creation_date: 2009-11-02T08:20:11Z [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003311 ! pancreatic D cell differentiation created_by: dph creation_date: 2009-11-02T08:23:26Z [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003312 ! pancreatic PP cell differentiation created_by: dph creation_date: 2009-11-02T08:25:03Z [Term] id: GO:0003326 name: pancreatic A cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003310 ! pancreatic A cell differentiation created_by: dph creation_date: 2009-11-02T08:29:00Z [Term] id: GO:0003327 name: type B pancreatic cell fate commitment namespace: biological_process def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003309 ! type B pancreatic cell differentiation created_by: dph creation_date: 2009-11-02T08:31:24Z [Term] id: GO:0003328 name: pancreatic D cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003311 ! pancreatic D cell differentiation created_by: dph creation_date: 2009-11-02T08:33:36Z [Term] id: GO:0003329 name: pancreatic PP cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003312 ! pancreatic PP cell differentiation created_by: dph creation_date: 2009-11-02T08:35:13Z [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070278 ! extracellular matrix constituent secretion relationship: regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:07:40Z [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070278 ! extracellular matrix constituent secretion relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:11:22Z [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:13:49Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: dph creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0030216 ! keratinocyte differentiation created_by: dph creation_date: 2009-11-24T08:55:57Z [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003334 ! keratinocyte development created_by: dph creation_date: 2009-11-24T09:01:02Z [Term] id: GO:0003336 name: corneocyte desquamation namespace: biological_process def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph] synonym: "epidermal desquamation" EXACT [GOC:dph] is_a: GO:0060232 ! delamination relationship: part_of GO:0003335 ! corneocyte development created_by: dph creation_date: 2009-11-24T09:11:53Z [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition is_a: GO:0072202 ! cell differentiation involved in metanephros development intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: part_of GO:0003338 ! metanephros morphogenesis relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis created_by: dph creation_date: 2009-11-24T09:29:49Z [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001656 ! metanephros development created_by: dph creation_date: 2009-11-24T09:32:09Z [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis created_by: dph creation_date: 2009-11-24T09:43:04Z [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis created_by: dph creation_date: 2009-11-24T09:46:12Z [Term] id: GO:0003341 name: cilium movement namespace: biological_process alt_id: GO:0036142 def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "flagellar motility" RELATED [] synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-11-24T09:56:26Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0003343 ! septum transversum development created_by: dph creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development created_by: dph creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060039 ! pericardium development created_by: dph creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003345 name: proepicardium cell migration involved in pericardium morphogenesis namespace: biological_process def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003344 ! pericardium morphogenesis created_by: dph creation_date: 2009-12-01T10:49:32Z [Term] id: GO:0003346 name: epicardium-derived cell migration to the myocardium namespace: biological_process def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development created_by: dph creation_date: 2009-12-01T11:00:42Z [Term] id: GO:0003347 name: epicardial cell to mesenchymal cell transition namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] is_a: GO:0001837 ! epithelial to mesenchymal transition created_by: dph creation_date: 2009-12-01T11:05:39Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation created_by: dph creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003349 name: epicardium-derived cardiac endothelial cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0003348 ! cardiac endothelial cell differentiation created_by: dph creation_date: 2009-12-01T11:17:49Z [Term] id: GO:0003350 name: pulmonary myocardium development namespace: biological_process def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060841 ! venous blood vessel development created_by: dph creation_date: 2009-12-01T12:50:06Z [Term] id: GO:0003351 name: epithelial cilium movement involved in extracellular fluid movement namespace: biological_process def: "The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid." [GOC:dph, GOC:krc] synonym: "cilium movement involved in fluid flow" RELATED [GOC:cilia] synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement is_a: GO:0006858 ! extracellular transport is_a: GO:0099111 ! microtubule-based transport created_by: dph creation_date: 2009-12-03T10:08:25Z [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process alt_id: GO:1900172 def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "regulation of flagellum movement" RELATED [] synonym: "regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003341 ! cilium movement relationship: regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:12:00Z [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process alt_id: GO:1900174 def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "positive regulation of flagellum movement" RELATED [] synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003341 ! cilium movement relationship: positively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:16:10Z [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process alt_id: GO:1900173 def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "negative regulation of flagellum movement" RELATED [] synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003341 ! cilium movement relationship: negatively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:17:47Z [Term] id: GO:0003355 name: cilium movement involved in otolith formation namespace: biological_process def: "The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles." [GOC:dph, GOC:krc, PMID:19043402] is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement intersection_of: GO:0003341 ! cilium movement intersection_of: part_of GO:0032475 ! otolith formation relationship: part_of GO:0032475 ! otolith formation created_by: dph creation_date: 2009-12-03T10:21:08Z [Term] id: GO:0003356 name: regulation of cilium beat frequency namespace: biological_process alt_id: GO:0036144 def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellum beat frequency" RELATED [] synonym: "regulation of microtubule-based flagellum beat frequency" EXACT [] is_a: GO:0003352 ! regulation of cilium movement created_by: dph creation_date: 2009-12-03T10:27:12Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation created_by: dph creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003357 ! noradrenergic neuron differentiation created_by: dph creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003359 name: noradrenergic neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0003357 ! noradrenergic neuron differentiation created_by: dph creation_date: 2009-12-03T10:41:08Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation intersection_of: GO:0003357 ! noradrenergic neuron differentiation intersection_of: part_of GO:0003360 ! brainstem development relationship: part_of GO:0003360 ! brainstem development created_by: dph creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003362 name: noradrenergic neuron fate commitment involved in brainstem development namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003359 ! noradrenergic neuron fate commitment intersection_of: GO:0003359 ! noradrenergic neuron fate commitment intersection_of: part_of GO:0003360 ! brainstem development relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development created_by: dph creation_date: 2009-12-03T10:56:16Z [Term] id: GO:0003363 name: lamellipodium assembly involved in ameboidal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030032 ! lamellipodium assembly intersection_of: GO:0030032 ! lamellipodium assembly intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0001667 ! ameboidal-type cell migration created_by: dph creation_date: 2009-12-08T04:38:04Z [Term] id: GO:0003364 name: lamellipodium assembly involved in mesendodermal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration is_a: GO:0010927 ! cellular component assembly involved in morphogenesis intersection_of: GO:0030032 ! lamellipodium assembly intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T04:46:39Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0001667 ! ameboidal-type cell migration created_by: dph creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003366 name: cell-matrix adhesion involved in ameboidal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007160 ! cell-matrix adhesion intersection_of: GO:0007160 ! cell-matrix adhesion intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0001667 ! ameboidal-type cell migration created_by: dph creation_date: 2009-12-08T04:54:33Z [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration created_by: dph creation_date: 2009-12-08T05:15:49Z [Term] id: GO:0003368 name: cell-matrix adhesion involved in mesendodermal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration intersection_of: GO:0007160 ! cell-matrix adhesion intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T05:26:12Z [Term] id: GO:0003369 name: establishment of cell polarity involved in mesendodermal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T05:31:51Z [Term] id: GO:0003370 name: cell-cell adhesion involved in mesendodermal cell migration namespace: biological_process def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration created_by: dph creation_date: 2009-12-08T05:33:51Z [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration created_by: dph creation_date: 2009-12-08T05:42:46Z [Term] id: GO:0003372 name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration created_by: dph creation_date: 2009-12-08T05:46:23Z [Term] id: GO:0003373 name: dynamin family protein polymerization involved in membrane fission namespace: biological_process def: "The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0090148 ! membrane fission created_by: dph creation_date: 2009-12-09T04:55:16Z [Term] id: GO:0003374 name: dynamin family protein polymerization involved in mitochondrial fission namespace: biological_process def: "The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003373 ! dynamin family protein polymerization involved in membrane fission created_by: dph creation_date: 2009-12-09T05:39:52Z [Term] id: GO:0003375 name: regulation of dynamin family protein polymerization involved in membrane fission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003373 ! dynamin family protein polymerization involved in membrane fission relationship: regulates GO:0003373 ! dynamin family protein polymerization involved in membrane fission created_by: dph creation_date: 2009-12-09T05:50:15Z [Term] id: GO:0003376 name: sphingosine-1-phosphate receptor signaling pathway namespace: biological_process alt_id: GO:0001789 def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15822 synonym: "S1P receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P signaling pathway" RELATED [GOC:bf] synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf] synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186] synonym: "sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "sphingolipid signalling pathway" BROAD [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0090520 ! sphingolipid mediated signaling pathway created_by: dph creation_date: 2009-12-09T06:30:12Z [Term] id: GO:0003377 name: obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah] is_obsolete: true created_by: dph creation_date: 2009-12-09T06:32:22Z [Term] id: GO:0003378 name: obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah] is_obsolete: true created_by: dph creation_date: 2009-12-09T06:38:06Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0042074 ! cell migration involved in gastrulation created_by: dph creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration created_by: dph creation_date: 2009-12-09T07:10:57Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation created_by: dph creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development created_by: dph creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis created_by: dph creation_date: 2009-12-09T07:30:34Z [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction intersection_of: GO:0003383 ! apical constriction intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation created_by: dph creation_date: 2009-12-09T07:35:38Z [Term] id: GO:0003385 name: cell-cell signaling involved in amphid sensory organ development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0003386 ! amphid sensory organ development relationship: part_of GO:0003386 ! amphid sensory organ development created_by: dph creation_date: 2009-12-09T08:55:37Z [Term] id: GO:0003386 name: amphid sensory organ development namespace: biological_process def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007423 ! sensory organ development created_by: dph creation_date: 2009-12-09T09:09:20Z [Term] id: GO:0003387 name: neuron differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030182 ! neuron differentiation intersection_of: part_of GO:0003386 ! amphid sensory organ development relationship: part_of GO:0003386 ! amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:15:00Z [Term] id: GO:0003388 name: neuron development involved in amphid sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048666 ! neuron development intersection_of: GO:0048666 ! neuron development intersection_of: part_of GO:0003386 ! amphid sensory organ development relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:18:06Z [Term] id: GO:0003389 name: retrograde extension namespace: biological_process def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031175 ! neuron projection development created_by: dph creation_date: 2009-12-09T09:22:03Z [Term] id: GO:0003390 name: dendrite development by retrograde extension namespace: biological_process def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003389 ! retrograde extension is_a: GO:0016358 ! dendrite development created_by: dph creation_date: 2009-12-09T09:25:24Z [Term] id: GO:0003391 name: amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:28:27Z [Term] id: GO:0003392 name: cell adhesion involved in retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0003389 ! retrograde extension relationship: part_of GO:0003389 ! retrograde extension created_by: dph creation_date: 2009-12-09T09:32:06Z [Term] id: GO:0003393 name: neuron migration involved in retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001764 ! neuron migration intersection_of: GO:0001764 ! neuron migration intersection_of: part_of GO:0003389 ! retrograde extension relationship: part_of GO:0003389 ! retrograde extension created_by: dph creation_date: 2009-12-09T09:36:03Z [Term] id: GO:0003394 name: cell adhesion involved in dendrite retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003392 ! cell adhesion involved in retrograde extension intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension created_by: dph creation_date: 2009-12-09T09:42:09Z [Term] id: GO:0003395 name: neuron migration involved in dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003393 ! neuron migration involved in retrograde extension intersection_of: GO:0001764 ! neuron migration intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension created_by: dph creation_date: 2009-12-09T09:44:24Z [Term] id: GO:0003396 name: cell adhesion involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension created_by: dph creation_date: 2009-12-09T09:50:18Z [Term] id: GO:0003397 name: neuron migration involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension intersection_of: GO:0001764 ! neuron migration intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension created_by: dph creation_date: 2009-12-09T09:52:18Z [Term] id: GO:0003398 name: glial cell differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0010001 ! glial cell differentiation intersection_of: part_of GO:0003386 ! amphid sensory organ development relationship: part_of GO:0003386 ! amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:55:27Z [Term] id: GO:0003399 name: cytoneme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis created_by: dph creation_date: 2009-12-09T10:03:32Z [Term] id: GO:0003400 name: regulation of COPII vesicle coating namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048208 ! COPII vesicle coating relationship: regulates GO:0048208 ! COPII vesicle coating created_by: dph creation_date: 2009-12-17T08:38:14Z [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis created_by: dph creation_date: 2009-12-21T01:12:15Z [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0003401 ! axis elongation relationship: part_of GO:0003401 ! axis elongation created_by: dph creation_date: 2009-12-21T01:22:11Z [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation created_by: dph creation_date: 2009-12-21T01:42:37Z [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T01:54:34Z [Term] id: GO:0003405 name: optic vesicle elongation namespace: biological_process def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis created_by: dph creation_date: 2009-12-21T01:59:50Z [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060041 ! retina development in camera-type eye created_by: dph creation_date: 2009-12-21T02:04:27Z [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060041 ! retina development in camera-type eye created_by: dph creation_date: 2009-12-21T02:15:14Z [Term] id: GO:0003408 name: optic cup formation involved in camera-type eye development namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development created_by: dph creation_date: 2009-12-21T02:37:12Z [Term] id: GO:0003409 name: optic cup structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "optic cup structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development created_by: dph creation_date: 2009-12-21T02:44:20Z [Term] id: GO:0003410 name: anterior rotation of the optic cup namespace: biological_process def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development created_by: dph creation_date: 2009-12-21T02:49:48Z [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T03:04:27Z [Term] id: GO:0003412 name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity intersection_of: GO:0045198 ! establishment of epithelial cell apical/basal polarity intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T03:09:23Z [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:39:58Z [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:42:55Z [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0002063 ! chondrocyte development created_by: dph creation_date: 2009-12-22T08:48:44Z [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth created_by: dph creation_date: 2009-12-22T08:52:55Z [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0003416 ! endochondral bone growth created_by: dph creation_date: 2009-12-22T08:57:42Z [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:00:56Z [Term] id: GO:0003419 name: growth plate cartilage chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:02:51Z [Term] id: GO:0003420 name: regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0046620 ! regulation of organ growth is_a: GO:0061035 ! regulation of cartilage development is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2009-12-22T09:07:40Z [Term] id: GO:0003421 name: growth plate cartilage axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T09:16:33Z [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:21:30Z [Term] id: GO:0003423 name: growth plate cartilage chondrocyte division namespace: biological_process def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051301 ! cell division relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2009-12-22T09:55:51Z [Term] id: GO:0003424 name: establishment of cell polarity involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T10:18:10Z [Term] id: GO:0003425 name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000132 ! establishment of mitotic spindle orientation is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity intersection_of: GO:0051294 ! establishment of spindle orientation intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T10:36:36Z [Term] id: GO:0003426 name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T11:38:22Z [Term] id: GO:0003427 name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0051302 ! regulation of cell division is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:2000114 ! regulation of establishment of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T11:43:29Z [Term] id: GO:0003428 name: chondrocyte intercalation involved in growth plate cartilage morphogenesis namespace: biological_process def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0060029 ! convergent extension involved in organogenesis created_by: dph creation_date: 2009-12-22T11:52:32Z [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis is_a: GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation created_by: dph creation_date: 2009-12-22T12:22:24Z [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T12:29:19Z [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation created_by: dph creation_date: 2009-12-22T12:32:49Z [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth intersection_of: GO:0048588 ! developmental cell growth intersection_of: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis created_by: dph creation_date: 2009-12-22T12:37:48Z [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T12:42:44Z [Term] id: GO:0003434 name: BMP signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T12:50:17Z [Term] id: GO:0003435 name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T01:02:42Z [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0030155 ! regulation of cell adhesion intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T01:28:15Z [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication intersection_of: GO:0010646 ! regulation of cell communication intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T01:34:24Z [Term] id: GO:0003673 name: obsolete Gene_Ontology namespace: biological_process def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "Gene_Ontology" EXACT [] is_obsolete: true [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] [Term] id: GO:0003675 name: obsolete protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "protein" EXACT [] is_obsolete: true [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] xref: MIPS_funcat:16.03 is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] xref: MIPS_funcat:16.03.01 is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 alt_id: GO:0004003 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.4.12, GOC:jl] synonym: "ATP-dependent DNA helicase activity" EXACT [] xref: EC:3.6.4.12 is_a: GO:0004386 ! helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0032508 ! DNA duplex unwinding [Term] id: GO:0003680 name: AT DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] synonym: "AT binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003681 name: bent DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" NARROW [] synonym: "microtubule/chromatin interaction" NARROW [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0003683 name: obsolete lamin/chromatin binding namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two functions. synonym: "lamin/chromatin binding" EXACT [] is_obsolete: true consider: GO:0003682 consider: GO:0005521 [Term] id: GO:0003684 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003685 name: obsolete DNA repair protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. synonym: "DNA repair protein" EXACT [] is_obsolete: true consider: GO:0003684 [Term] id: GO:0003686 name: obsolete DNA repair enzyme namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. synonym: "DNA repair enzyme" EXACT [] is_obsolete: true consider: GO:0003684 [Term] id: GO:0003687 name: obsolete DNA replication factor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication factor" EXACT [] is_obsolete: true consider: GO:0006260 [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] synonym: "ARS binding" NARROW [] xref: MIPS_funcat:10.01.03.03 is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003689 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: Reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity [Term] id: GO:0003690 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh, GOC:vw] synonym: "dsDNA binding" EXACT [GOC:elh] is_a: GO:0003677 ! DNA binding disjoint_from: GO:0003697 ! single-stranded DNA binding [Term] id: GO:0003691 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0003692 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0003693 name: P-element binding namespace: molecular_function def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003694 name: obsolete plasmid binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732] comment: This term was made obsolete because it refers to component information. synonym: "plasmid binding" EXACT [] synonym: "plasmid-associated protein" RELATED [] is_obsolete: true consider: GO:0003677 consider: GO:0005727 [Term] id: GO:0003695 name: random coil DNA binding namespace: molecular_function alt_id: GO:0016017 def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003700 name: DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 alt_id: GO:0001071 alt_id: GO:0001130 alt_id: GO:0001131 alt_id: GO:0001151 alt_id: GO:0001199 alt_id: GO:0001204 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes. \nChanged definition see https://github.com/geneontology/go-ontology/issues/15704\nMerged term see https://github.com/geneontology/go-ontology/issues/16534 subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial-type DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW [] synonym: "DNA binding transcription factor activity" EXACT [] synonym: "gene-specific transcription factor activity" EXACT [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "nucleic acid binding transcription factor activity" BROAD [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] synonym: "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW [] synonym: "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] is_a: GO:0140110 ! transcription regulator activity relationship: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated created_by: kchris creation_date: 2010-10-21T04:37:54Z [Term] id: GO:0003701 name: obsolete RNA polymerase I transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase I transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001181 consider: GO:0006360 [Term] id: GO:0003702 name: obsolete RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000981 consider: GO:0006366 [Term] id: GO:0003704 name: obsolete specific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "specific RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000981 consider: GO:0006366 [Term] id: GO:0003706 name: obsolete ligand-regulated transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators] comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. synonym: "ligand-regulated transcription factor activity" EXACT [] is_obsolete: true consider: GO:0004879 consider: GO:0030374 [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway [Term] id: GO:0003709 name: obsolete RNA polymerase III transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase III transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000995 consider: GO:0006383 [Term] id: GO:0003711 name: transcription elongation regulator activity namespace: molecular_function def: "A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription." [GOC:txnOH-2018, PMID:23878398, PMID:28892040] comment: Restored term, see https://github.com/geneontology/go-ontology/issues/14398 synonym: "transcription elongation factor activity" EXACT [] synonym: "transcription elongation regulator activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0003712 name: transcription coregulator activity namespace: molecular_function alt_id: GO:0001104 alt_id: GO:0016455 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] comment: Curator guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.\nFixed term label and definition, see https://github.com/geneontology/go-ontology/issues/15998; Changed parents, see https://github.com/geneontology/go-ontology/issues/15536; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 subset: goslim_drosophila synonym: "RNA polymerase II transcriptional cofactor activity" RELATED [] synonym: "transcription cofactor activity" EXACT [] synonym: "transcriptional co-regulator" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: part_of GO:1903506 ! regulation of nucleic acid-templated transcription created_by: kchris creation_date: 2010-11-24T03:02:15Z [Term] id: GO:0003713 name: transcription coactivator activity namespace: molecular_function alt_id: GO:0001105 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] comment: Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 synonym: "RNA polymerase II transcription co-activator activity" RELATED [] synonym: "RNA polymerase II transcription coactivator activity" RELATED [] synonym: "RNA polymerase II transcription mediator activity" RELATED [] synonym: "transcription co-activator activity" EXACT [] synonym: "transcription coactivator activity" EXACT [] is_a: GO:0003712 ! transcription coregulator activity relationship: part_of GO:1903508 ! positive regulation of nucleic acid-templated transcription created_by: kchris creation_date: 2010-11-24T03:08:19Z [Term] id: GO:0003714 name: transcription corepressor activity namespace: molecular_function alt_id: GO:0001106 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] comment: Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 synonym: "RNA polymerase II transcription co-repressor activity" RELATED [] synonym: "RNA polymerase II transcription corepressor activity" RELATED [] synonym: "transcription co-repressor activity" EXACT [] synonym: "transcription corepressor activity" EXACT [] is_a: GO:0003712 ! transcription coregulator activity relationship: part_of GO:1903507 ! negative regulation of nucleic acid-templated transcription created_by: kchris creation_date: 2010-11-24T03:14:44Z [Term] id: GO:0003715 name: obsolete transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription termination factor activity" EXACT [] synonym: "transcriptional termination factor activity" EXACT [] is_obsolete: true consider: GO:0006353 [Term] id: GO:0003716 name: obsolete RNA polymerase I transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription termination factor activity" EXACT [] synonym: "RNA polymerase I transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006363 [Term] id: GO:0003717 name: obsolete RNA polymerase II transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription termination factor activity" EXACT [] synonym: "RNA polymerase II transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006369 [Term] id: GO:0003718 name: obsolete RNA polymerase III transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription termination factor activity" EXACT [] synonym: "RNA polymerase III transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006386 [Term] id: GO:0003719 name: obsolete transcription factor binding, cytoplasmic sequestering namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process rather than a function. synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] is_obsolete: true replaced_by: GO:0042994 [Term] id: GO:0003720 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] xref: EC:2.7.7 xref: Reactome:R-HSA-163090 "Elongation Of The Telomeric Chromosome End" xref: Reactome:R-HSA-164617 "Elongation of Extended Telomeric Chromosome End" is_a: GO:0003964 ! RNA-directed DNA polymerase activity [Term] id: GO:0003721 name: telomerase RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] is_a: GO:0003964 ! RNA-directed DNA polymerase activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0000498 alt_id: GO:0044822 def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: MIPS_funcat:16.03.03 xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003724 name: RNA helicase activity namespace: molecular_function alt_id: GO:0004004 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.4.13, GOC:jl] synonym: "ATP-dependent RNA helicase activity" EXACT [] xref: EC:3.6.4.13 xref: Reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases" is_a: GO:0004386 ! helicase activity is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0003725 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] synonym: "dsRNA binding" EXACT [GOC:ecd] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003726 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function alt_id: GO:0003971 def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] synonym: "double-stranded RNA specific editase activity" RELATED [] xref: Reactome:R-HSA-77614 "Deamination at C6 position of adenosine in Editosome (ADAR1)" xref: Reactome:R-HSA-77615 "Deamination at C6 position of adenosine in Editosome (ADAR2)" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function alt_id: GO:0000499 def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "base pairing with mRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003730 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0003731 name: obsolete mRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. synonym: "mRNA cap binding" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0003732 name: obsolete snRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. synonym: "snRNA cap binding" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0003733 name: obsolete ribonucleoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "ribonucleoprotein" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0003734 name: obsolete small nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] is_obsolete: true replaced_by: GO:0030532 [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005840 ! ribosome relationship: occurs_in GO:0005840 ! ribosome [Term] id: GO:0003743 name: translation initiation factor activity namespace: molecular_function alt_id: GO:0003744 alt_id: GO:0003745 def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] xref: Reactome:R-HSA-72621 "Ribosomal scanning" xref: Reactome:R-HSA-72697 "Start codon recognition" xref: Reactome:R-HSA-72722 "eIF2 activation" is_a: GO:0008135 ! translation factor activity, RNA binding relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0003746 name: translation elongation factor activity namespace: molecular_function alt_id: GO:0008182 alt_id: GO:0008183 def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] xref: Reactome:R-HSA-192704 "Synthesis of PB1-F2" xref: Reactome:R-HSA-192841 "Viral Protein Synthesis" is_a: GO:0008135 ! translation factor activity, RNA binding relationship: part_of GO:0006414 ! translational elongation [Term] id: GO:0003747 name: translation release factor activity namespace: molecular_function alt_id: GO:0003748 alt_id: GO:0003749 def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] is_a: GO:0008079 ! translation termination factor activity [Term] id: GO:0003750 name: obsolete cell cycle regulator namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a single molecular function. synonym: "cell cycle regulator" EXACT [] is_obsolete: true replaced_by: GO:0051726 [Term] id: GO:0003754 name: obsolete chaperone activity namespace: molecular_function alt_id: GO:0003757 alt_id: GO:0003758 alt_id: GO:0003760 alt_id: GO:0003761 def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. synonym: "chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003755 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function alt_id: GO:0004752 alt_id: GO:0042028 def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN xref: Reactome:R-HSA-2022073 "Procollagen triple helix formation" xref: Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1" is_a: GO:0016859 ! cis-trans isomerase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0000413 ! protein peptidyl-prolyl isomerization [Term] id: GO:0003756 name: protein disulfide isomerase activity namespace: molecular_function alt_id: GO:0006467 def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, http://en.wikipedia.org/wiki/Protein_disulfide-isomerase#Function] synonym: "disulphide bond biosynthesis" EXACT [] synonym: "disulphide bond formation" EXACT [] synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "protein thiol-disulfide exchange" EXACT [] synonym: "protein thiol-disulphide exchange" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: MetaCyc:5.3.4.1-RXN xref: Reactome:R-HSA-8950113 "IL12A binds IL12B" xref: Reactome:R-HSA-8950183 "IL12B binds IL23A" xref: Reactome:R-HSA-8950456 "IL12B dimerizes" is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0003759 name: obsolete glycoprotein-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "glycoprotein-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003762 name: obsolete histone-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "histone-specific chaperone activity" EXACT [] synonym: "nucleosome assembly chaperone" EXACT [] is_obsolete: true consider: GO:0006333 consider: GO:0006334 consider: GO:0034728 consider: GO:0042393 consider: GO:0043486 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003763 name: obsolete chaperonin ATPase activity namespace: molecular_function alt_id: GO:0003764 alt_id: GO:0003765 alt_id: GO:0003766 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "chaperonin" EXACT [] synonym: "chaperonin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0003767 name: obsolete co-chaperone activity namespace: molecular_function alt_id: GO:0003768 alt_id: GO:0003769 alt_id: GO:0003770 alt_id: GO:0003771 def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "co-chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003772 name: obsolete co-chaperonin activity namespace: molecular_function def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "co-chaperonin activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003773 name: obsolete heat shock protein activity namespace: molecular_function def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "heat shock protein activity" EXACT [] is_obsolete: true consider: GO:0006986 consider: GO:0042026 [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_plant xref: MIPS_funcat:16.06 xref: Reactome:R-HSA-1861595 "Extension of pseudopodia by myosin-X in a PI3K dependent manner" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003775 name: obsolete axonemal motor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. synonym: "axonemal motor activity" EXACT [] is_obsolete: true consider: GO:0003777 consider: GO:0005930 [Term] id: GO:0003776 name: obsolete muscle motor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes anatomy information. synonym: "muscle motor activity" EXACT [] is_obsolete: true replaced_by: GO:0000146 consider: GO:0006936 consider: GO:0043292 [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: Reactome:R-HSA-177479 "Axonal transport of NGF:Trk complexes" xref: Reactome:R-HSA-265160 "Insulin secretory granule translocates to cell cortex" is_a: GO:0003774 ! motor activity [Term] id: GO:0003778 name: obsolete dynactin motor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. synonym: "dynactin motor" EXACT [] is_obsolete: true [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0003780 name: obsolete actin cross-linking activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] comment: This term was made obsolete because it represents a combination of molecular functions. synonym: "actin cross-linking activity" EXACT [] is_obsolete: true consider: GO:0030674 consider: GO:0051015 [Term] id: GO:0003781 name: obsolete actin bundling activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin bundling activity" EXACT [] is_obsolete: true replaced_by: GO:0051017 [Term] id: GO:0003782 name: obsolete F-actin capping activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "F-actin capping activity" EXACT [] is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003783 name: obsolete barbed-end actin capping activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "barbed-end actin capping activity" EXACT [] is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003784 name: obsolete barbed-end actin capping/severing activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes two biological processes. synonym: "barbed-end actin capping/severing activity" EXACT [] is_obsolete: true consider: GO:0051014 consider: GO:0051016 [Term] id: GO:0003785 name: actin monomer binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0003786 name: actin lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah] is_a: GO:0051015 ! actin filament binding [Term] id: GO:0003787 name: obsolete actin depolymerizing activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin depolymerizing activity" EXACT [] is_obsolete: true replaced_by: GO:0030042 [Term] id: GO:0003788 name: obsolete actin monomer sequestering activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process, not an activity. synonym: "actin monomer sequestering activity" EXACT [] is_obsolete: true replaced_by: GO:0042989 [Term] id: GO:0003789 name: obsolete actin filament severing activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "actin filament severing activity" EXACT [] is_obsolete: true replaced_by: GO:0051014 [Term] id: GO:0003790 name: obsolete actin modulating activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not make sense. synonym: "actin modulating activity" EXACT [] is_obsolete: true consider: GO:0030036 [Term] id: GO:0003791 name: obsolete membrane associated actin binding namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "membrane associated actin binding" EXACT [] is_obsolete: true consider: GO:0003779 consider: GO:0016020 [Term] id: GO:0003792 name: obsolete regulation of actin thin filament length activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the term belongs in the process ontology. synonym: "regulation of actin thin filament length activity" EXACT [] is_obsolete: true replaced_by: GO:0030832 [Term] id: GO:0003793 name: obsolete defense/immunity protein activity namespace: molecular_function def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "defence/immunity protein activity" EXACT [] synonym: "defense/immunity protein activity" EXACT [] is_obsolete: true consider: GO:0006952 [Term] id: GO:0003794 name: obsolete acute-phase response protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "acute-phase response protein activity" EXACT [] is_obsolete: true consider: GO:0006953 [Term] id: GO:0003795 name: obsolete antimicrobial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antimicrobial peptide activity" EXACT [] is_obsolete: true consider: GO:0019730 [Term] id: GO:0003796 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813] synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: MetaCyc:3.2.1.17-RXN xref: Reactome:R-HSA-8862320 "LYZ hydrolyzes peptidoglycans in the bacterial cell wall" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0003797 name: obsolete antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0042742 [Term] id: GO:0003798 name: obsolete male-specific antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "male-specific antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050831 [Term] id: GO:0003799 name: obsolete antifungal peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antifungal peptide activity" EXACT [] is_obsolete: true consider: GO:0050832 [Term] id: GO:0003800 name: obsolete antiviral response protein activity namespace: molecular_function def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "antiviral response protein activity" EXACT [] is_obsolete: true consider: GO:0009615 [Term] id: GO:0003801 name: obsolete blood coagulation factor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "blood coagulation factor activity" EXACT [] is_obsolete: true consider: GO:0004252 consider: GO:0007596 [Term] id: GO:0003802 name: obsolete coagulation factor VIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] synonym: "coagulation factor VIIa activity" EXACT [] xref: EC:3.4.21.21 xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003803 name: obsolete coagulation factor IXa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] synonym: "coagulation factor IXa activity" EXACT [] xref: EC:3.4.21.22 xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003804 name: obsolete coagulation factor Xa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "coagulation factor Xa activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003805 name: obsolete coagulation factor XIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "coagulation factor XIa activity" EXACT [] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003806 name: obsolete coagulation factor XIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] comment: This term was made obsolete because it represents a gene product. synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "coagulation factor XIIa activity" EXACT [] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003807 name: obsolete plasma kallikrein activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "plasma kallikrein activity" EXACT [] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003808 name: obsolete protein C (activated) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein C (activated) activity" EXACT [] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003809 name: obsolete thrombin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin activity" EXACT [] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003810 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: MetaCyc:2.3.2.13-RXN xref: Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+" xref: Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking" xref: RESID:AA0124 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003811 name: obsolete complement activity namespace: molecular_function def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "complement activity" EXACT [] is_obsolete: true consider: GO:0006956 [Term] id: GO:0003812 name: obsolete alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] comment: This term was made obsolete because it represents a gene product. synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "alternative-complement-pathway C3/C5 convertase activity" EXACT [] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003813 name: obsolete classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] comment: This term was made obsolete because it represents a gene product. synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT [] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003815 name: obsolete complement component C1r activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement component C1r activity" EXACT [] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003816 name: obsolete complement component C1s activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement component C1s activity" EXACT [] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003817 name: obsolete complement factor D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] comment: This term was made obsolete because it represents a gene product. synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "complement factor D activity" EXACT [] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003818 name: obsolete complement factor I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] comment: This term was made obsolete because it represents a gene product. synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "complement factor I activity" EXACT [] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003819 name: obsolete major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "major histocompatibility complex antigen" EXACT [] synonym: "MHC protein" EXACT [] is_obsolete: true [Term] id: GO:0003820 name: obsolete class I major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "class I major histocompatibility complex antigen" EXACT [] is_obsolete: true consider: GO:0042612 [Term] id: GO:0003821 name: obsolete class II major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "class II major histocompatibility complex antigen" EXACT [] is_obsolete: true consider: GO:0042613 [Term] id: GO:0003822 name: obsolete MHC-interacting protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "MHC-interacting protein" EXACT [] is_obsolete: true [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544] subset: goslim_chembl subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003825 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15] synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: MetaCyc:TREHALOSE6PSYN-RXN xref: RHEA:18889 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003826 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0003827 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11456] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: KEGG_REACTION:R05983 xref: MetaCyc:2.4.1.101-RXN xref: Reactome:R-HSA-964768 "Addition of GlcNAc to the glycan on the A arm" xref: RHEA:11456 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003828 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: MetaCyc:2.4.99.8-RXN xref: Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans" xref: Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues" xref: Reactome:R-HSA-422454 "Polysialylation of NCAM1" xref: RHEA:19313 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003829 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: MetaCyc:2.4.1.102-RXN xref: Reactome:R-HSA-914012 "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins" xref: Reactome:R-HSA-914018 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein" xref: RHEA:18705 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003830 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN xref: Reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3" is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003831 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: MetaCyc:2.4.1.38-RXN xref: Reactome:R-HSA-1912352 "Galactosylation of Pre-NOTCH" xref: Reactome:R-HSA-2025723 "B4GALTs transfer Gal to the N-glycan precursor" xref: Reactome:R-HSA-2046265 "B4GALTs transfer Gal to the keratan chain" xref: Reactome:R-HSA-2046298 "B4GALTs transfer Gal to a branch of keratan" xref: Reactome:R-HSA-3656230 "Defective B4GALT1 does not transfer Gal to the keratan chain" xref: Reactome:R-HSA-4793956 "Defective B4GALT1 does not add Gal to N-glycan" xref: Reactome:R-HSA-9035949 "Defective B4GALT1 does not transfer Gal to the N-glycan precursor" xref: Reactome:R-HSA-9035950 "Defective B4GALT1 does not transfer Gal to a branch of keratan" xref: Reactome:R-HSA-975919 "Addition of galactose by beta 4-galactosyltransferases" xref: RHEA:22932 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003832 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003833 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0003834 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: KEGG_REACTION:R00032 xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN xref: Reactome:R-HSA-975635 "BCMO1:Fe2+ cleaves betaC to atRAL" xref: RHEA:10407 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003835 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: MetaCyc:2.4.99.1-RXN xref: Reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)" xref: Reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans" xref: Reactome:R-HSA-977071 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position" xref: Reactome:R-HSA-977228 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position" xref: RHEA:11836 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003836 name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: MetaCyc:2.4.99.4-RXN xref: Reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans" xref: Reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH" xref: Reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid" xref: Reactome:R-HSA-3656258 "Defective ST3GAL3 does not transfer SA to keratan" xref: Reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)" xref: Reactome:R-HSA-9603987 "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG" xref: Reactome:R-HSA-9605600 "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG" xref: Reactome:R-HSA-981497 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position" xref: RHEA:21616 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003837 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: Reactome:R-HSA-73591 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2" xref: Reactome:R-HSA-73620 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2" xref: RHEA:11184 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003838 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: MetaCyc:RXN3O-178 xref: RHEA:21128 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0003839 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [] synonym: "L-glutamic cyclase activity" EXACT [] xref: EC:4.3.2.9 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN xref: Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO" xref: Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0003840 name: obsolete gamma-glutamyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] comment: This term was obsoleted because it does not correspond to a physiological reaction.\nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity). synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: KEGG_REACTION:R04159 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN is_obsolete: true consider: GO:0036374 [Term] id: GO:0003841 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function alt_id: GO:0004469 def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51] xref: EC:2.3.1.51 xref: MetaCyc:RXN-1623 xref: Reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT" xref: Reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT" xref: Reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)" xref: Reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7" xref: Reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT" xref: Reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT" xref: Reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)" xref: Reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)" xref: Reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)" xref: Reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine" xref: RHEA:19709 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity [Term] id: GO:0003842 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12] synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: Reactome:R-HSA-6784399 "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate" xref: Reactome:R-HSA-70679 "ALDH4A1 oxidises L-GluSS to Glu" xref: RHEA:16417 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0003843 name: 1,3-beta-D-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003844 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: Reactome:R-HSA-3322005 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a" xref: Reactome:R-HSA-3322016 "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a" xref: Reactome:R-HSA-3322057 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" xref: Reactome:R-HSA-3878762 "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0003845 name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036] synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: Reactome:R-HSA-194023 "HSD11B2,HSD11B1 dimer oxidise CORT to COR" xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003846 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG" xref: Reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG" xref: RHEA:16741 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: goslim_chembl synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN xref: Reactome:R-HSA-8869206 "PAFAH2 hydrolyses PAF to lyso-PAF and acetate" xref: RHEA:17777 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11412] subset: goslim_chembl synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG_REACTION:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11412 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0003849 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14717] comment: Note that this function was formerly EC:4.1.2.15. synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: KEGG_REACTION:R01826 xref: MetaCyc:DAHPSYN-RXN xref: RHEA:14717 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003850 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: KEGG_REACTION:R02587 xref: MetaCyc:3.1.3.68-RXN xref: RHEA:22236 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0003851 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.47 xref: MetaCyc:2.4.1.45-RXN xref: RHEA:10856 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003852 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21524] comment: Note that this function was formerly EC:4.1.3.12. synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: KEGG_REACTION:R01213 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN xref: RHEA:21524 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003853 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN xref: RHEA:13261 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0003854 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145] synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: MetaCyc:1.1.1.145-RXN xref: Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one" xref: Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one" xref: Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one" xref: Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione" xref: Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003855 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21096] synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: KEGG_REACTION:R03084 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN xref: RHEA:21096 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003856 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21968] xref: EC:4.2.3.4 xref: KEGG_REACTION:R03083 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN xref: RHEA:21968 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003857 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079] synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] xref: EC:1.1.1.35 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA" xref: Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA" xref: Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+" xref: Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA" xref: Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+" xref: Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA" xref: Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+" xref: Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H" xref: Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H" xref: Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H" xref: Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H" xref: Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H" xref: Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H" xref: Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H" xref: RHEA:22432 xref: UM-BBD_enzymeID:e0664 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003858 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20521] synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: KEGG_REACTION:R01361 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-5696457 "BDH2 dehydrogenates 3HBA" xref: Reactome:R-HSA-73912 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+" xref: Reactome:R-HSA-73920 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+" xref: RHEA:20521 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003859 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17849] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: KEGG_REACTION:R03027 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN xref: RHEA:17849 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003860 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: Reactome:R-HSA-70881 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA" xref: RHEA:20888 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003861 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate." [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003862 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN xref: RHEA:25082 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003863 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0003864 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN xref: RHEA:11824 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0003865 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: MetaCyc:1.3.99.5-RXN xref: Reactome:R-HSA-469659 "Testosterone is converted to 5-alpha-dihydroxytestosterone" is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0003866 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21256] synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: KEGG_REACTION:R03460 xref: MetaCyc:2.5.1.19-RXN xref: RHEA:21256 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003867 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [GOC:mah] synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [] synonym: "aminobutyrate aminotransferase activity" EXACT [] synonym: "aminobutyrate transaminase activity" EXACT [] synonym: "beta-alanine aminotransferase" RELATED [] synonym: "GABA aminotransferase activity" EXACT [] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [] synonym: "gamma-aminobutyrate transaminase activity" EXACT [] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [] xref: MetaCyc:GABATRANSAM-RXN xref: Reactome:R-HSA-916855 "Conversion of GABA to Succinate Semialdehyde" xref: RHEA:23352 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003868 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: Reactome:R-HSA-71163 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2" xref: RHEA:16189 xref: UM-BBD_reactionID:r0298 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003870 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12921] synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: KEGG_REACTION:R00830 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: Reactome:R-HSA-189442 "ALAS condenses SUCC-CoA and Gly to form dALA" xref: RHEA:12921 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0003871 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21196] synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: KEGG_REACTION:R04405 xref: MetaCyc:HOMOCYSMET-RXN xref: RHEA:21196 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: GO:0003872 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: MetaCyc:6PFRUCTPHOS-RXN xref: Reactome:R-HSA-70467 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP" xref: RHEA:16109 is_a: GO:0008443 ! phosphofructokinase activity relationship: part_of GO:0061615 ! glycolytic process through fructose-6-phosphate [Term] id: GO:0003873 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15653] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: KEGG_REACTION:R02732 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: Reactome:R-HSA-71802 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP" xref: RHEA:15653 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003874 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22048] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: KEGG_REACTION:R04286 xref: MetaCyc:4.2.3.12-RXN xref: Reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP" xref: RHEA:22048 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003875 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN xref: RHEA:20784 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003876 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: MetaCyc:AMP-DEAMINASE-RXN xref: Reactome:R-HSA-76590 "AMP + H2O => IMP + NH4+ (AMPD)" xref: RHEA:14777 is_a: GO:0047623 ! adenosine-phosphate deaminase activity [Term] id: GO:0003877 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN xref: RHEA:16577 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003878 name: ATP citrate synthase activity namespace: molecular_function alt_id: GO:0046913 def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21160] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: KEGG_REACTION:R00352 xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN xref: MetaCyc:PWY-5172 xref: Reactome:R-HSA-75848 "ACLY tetramer transforms CIT to Ac-CoA" xref: RHEA:21160 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003879 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN xref: RHEA:18473 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003880 name: protein C-terminal carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity relationship: part_of GO:0006481 ! C-terminal protein methylation [Term] id: GO:0003881 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11580] synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: KEGG_REACTION:R01802 xref: MetaCyc:2.7.8.11-RXN xref: Reactome:R-HSA-1482976 "CDP-DAG is converted to PI by CDIPT" xref: RHEA:11580 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN xref: RHEA:16913 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003883 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: MetaCyc:CTPSYN-RXN xref: Reactome:R-HSA-504054 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]" xref: Reactome:R-HSA-73647 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]" xref: RHEA:16597 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003884 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN xref: Reactome:R-HSA-389821 "glycine + O2 => glyoxylate + H2O2 + NH4+" xref: RHEA:21816 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0003885 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23756] synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: KEGG_REACTION:R02715 xref: MetaCyc:1.1.3.37-RXN xref: RHEA:23756 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003886 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function alt_id: GO:0008326 def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0090116 ! C-5 methylation of cytosine [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:R-HSA-110311 "POLZ extends translesion synthesis" xref: Reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH" xref: Reactome:R-HSA-110319 "Elongation by POLH" xref: Reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis" xref: Reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site" xref: Reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand" xref: Reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis" xref: Reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments" xref: Reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap" xref: Reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution" xref: Reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis" xref: Reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS" xref: Reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base" xref: Reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini" xref: Reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base" xref: Reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP" xref: Reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps" xref: Reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ" xref: Reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER" xref: Reactome:R-HSA-5693593 "D-loop extension by DNA polymerases" xref: Reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER" xref: Reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN" xref: Reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin" xref: Reactome:R-HSA-69116 "Formation of Okazaki fragments" xref: Reactome:R-HSA-73932 "Resynthesis of excised residue by POLB" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003892 name: obsolete proliferating cell nuclear antigen namespace: molecular_function alt_id: GO:0005661 def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "PCNA" EXACT [] synonym: "proliferating cell nuclear antigen" EXACT [] is_obsolete: true [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] xref: EC:2.7.7.101 is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity relationship: part_of GO:0006269 ! DNA replication, synthesis of RNA primer [Term] id: GO:0003899 name: DNA-directed 5'-3' RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase activity" BROAD [] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30" xref: Reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition" xref: Reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript" xref: Reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition" xref: Reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript" xref: Reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript" xref: Reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes" xref: Reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene" xref: Reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript" xref: Reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template" xref: Reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin" xref: Reactome:R-HSA-74986 "Elongation of pre-rRNA transcript" xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript" xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition" xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript" xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition" is_a: GO:0034062 ! 5'-3' RNA polymerase activity relationship: part_of GO:0032774 ! RNA biosynthetic process [Term] id: GO:0003900 name: obsolete DNA-directed RNA polymerase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. synonym: "DNA-directed RNA polymerase I activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003901 name: obsolete DNA-directed RNA polymerase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. synonym: "DNA-directed RNA polymerase II activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003902 name: obsolete DNA-directed RNA polymerase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. synonym: "DNA-directed RNA polymerase III activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003904 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3] synonym: "CPD photolyase activity" EXACT [PMID:16302973] synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN xref: RHEA:10672 is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0003906 name: DNA-(apurinic or apyrimidinic site) endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease] synonym: "abasic deoxyendoribonuclease activity" EXACT [] synonym: "AP deoxyendoribonuclease activity" EXACT [] synonym: "apurinic deoxyendoribonuclease activity" EXACT [] synonym: "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT [] synonym: "apyrimidinic deoxyendoribonuclease activity" EXACT [] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] synonym: "UV endonuclease" BROAD [] xref: Reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break" xref: Reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site" xref: Reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)" is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003908 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal" is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0003909 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094] xref: Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA" xref: Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA" xref: Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break" xref: Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB" xref: Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB" xref: Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ" xref: Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER" xref: Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ" xref: Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER" xref: Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments" xref: Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway" is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0006266 ! DNA ligation [Term] id: GO:0003910 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: MetaCyc:DNA-LIGASE-ATP-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003911 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: MetaCyc:DNA-LIGASE-NAD+-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003912 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003913 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] xref: EC:\:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0016830 ! carbon-carbon lyase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003914 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] xref: EC:4.1.99.13 xref: MetaCyc:RXN-10771 is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] xref: MetaCyc:5.99.1.2-RXN is_a: GO:0016853 ! isomerase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: has_part GO:0003677 ! DNA binding [Term] id: GO:0003917 name: DNA topoisomerase type I (single strand cut, ATP-independent) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. synonym: "deoxyribonucleate topoisomerase" BROAD [] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.6.2.1] synonym: "omega-protein activity" RELATED [EC:5.6.2.1] synonym: "relaxing enzyme activity" RELATED [EC:5.6.2.1] synonym: "swivelase activity" RELATED [EC:5.6.2.1] synonym: "topoisomerase" BROAD [EC:5.6.2.1] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.6.2.1] xref: EC:5.6.2.1 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003918 name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity namespace: molecular_function alt_id: GO:0061505 def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] synonym: "deoxyribonucleate topoisomerase" BROAD [GOC:krc] synonym: "deoxyribonucleic topoisomerase activity" BROAD [EC:5.6.2.2, GOC:krc] synonym: "DNA topoisomerase (ATP-hydrolysing)" EXACT [EC:5.6.2.2, GOC:krc] synonym: "DNA topoisomerase II" NARROW [EC:5.6.2.2, GOC:krc] synonym: "DNA topoisomerase II activity" NARROW [GOC:krc] synonym: "DNA topoisomerase IV activity" NARROW [GOC:krc] synonym: "DNA topoisomerase type II activity" EXACT [GOC:krc] synonym: "topoisomerase" BROAD [EC:5.6.2.2, GOC:krc] synonym: "topoisomerase II" NARROW [GOC:krc] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.6.2.2, GOC:krc] xref: EC:5.6.2.2 xref: MetaCyc:5.99.1.3-RXN xref: Wikipedia:Type_II_topoisomerase is_a: GO:0003916 ! DNA topoisomerase activity is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0003919 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17237] synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: KEGG_REACTION:R00161 xref: MetaCyc:FADSYN-RXN xref: Reactome:R-HSA-196929 "FLAD1 phosphorylates FMN" xref: RHEA:17237 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003920 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17185] comment: Note that this function was formerly EC:1.6.6.8. synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: KEGG_REACTION:R01134 xref: MetaCyc:GMP-REDUCT-RXN xref: Reactome:R-HSA-514604 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)" xref: RHEA:17185 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0003921 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+)." [RHEA:18301] xref: MetaCyc:GMP-SYN-NH3-RXN xref: RHEA:18301 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds relationship: part_of GO:0003922 ! GMP synthase (glutamine-hydrolyzing) activity [Term] id: GO:0003922 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+)." [RHEA:11680] synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: MetaCyc:GMP-SYN-GLUT-RXN xref: Reactome:R-HSA-73792 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate" xref: RHEA:11680 xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor relationship: part_of GO:0006177 ! GMP biosynthetic process [Term] id: GO:0003923 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309] xref: Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP" xref: Reactome:R-HSA-1458485 "RALA hydrolyzes GTP" xref: Reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP" xref: Reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP" xref: Reactome:R-HSA-167415 "G-protein alpha subunit is inactivated" xref: Reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf" xref: Reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf" xref: Reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha" xref: Reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle" xref: Reactome:R-HSA-203973 "Vesicle budding" xref: Reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome" xref: Reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle" xref: Reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP" xref: Reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP" xref: Reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP" xref: Reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission" xref: Reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha" xref: Reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission" xref: Reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC" xref: Reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA" xref: Reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome" xref: Reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits" xref: Reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)" xref: Reactome:R-HSA-555065 "Formation of clathrin coated vesicle" xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4" xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP" xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity" xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" xref: Reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP" xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase" xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity" xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP" xref: Reactome:R-HSA-8847534 "RAB43 hydrolyses GTP" xref: Reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity" xref: Reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity" xref: Reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35" xref: Reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7" xref: Reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7" xref: Reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A" xref: Reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B" xref: Reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission" xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity" xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated" xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated" xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated" xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle" xref: RHEA:19669 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003925 name: obsolete small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] comment: This term was made obsolete because it represents a gene product and contains cellular component information. synonym: "small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 [Term] id: GO:0003926 name: obsolete ARF small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "ARF small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003927 name: obsolete heterotrimeric G-protein GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] comment: This term was made obsolete because it represents a cellular component. synonym: "heterotrimeric G-protein GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0003928 name: obsolete RAB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAB small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003929 name: obsolete RAN small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAN small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006606 [Term] id: GO:0003930 name: obsolete RAS small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAS small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 [Term] id: GO:0003931 name: obsolete Rho small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "Rho small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0007010 [Term] id: GO:0003932 name: obsolete SAR small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "SAR small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0046903 [Term] id: GO:0003933 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators] is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003934 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: KEGG_REACTION:R00424 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN xref: Reactome:R-HSA-1474146 "GCH1 reduces GTP to dihydroneopterin triphosphate" xref: RHEA:17473 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003935 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23704] synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: KEGG_REACTION:R00425 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN xref: RHEA:23704 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003936 name: obsolete hydrogen-transporting two-sector ATPase activity namespace: molecular_function alt_id: GO:0004006 alt_id: GO:0008729 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "hydrogen-transporting two-sector ATPase activity" EXACT [] synonym: "proton-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:R-HSA-73797 "FAICAR => IMP + H2O" xref: RHEA:18445 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003938 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: MetaCyc:IMP-DEHYDROG-RXN xref: Reactome:R-HSA-73794 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]" xref: RHEA:11708 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003939 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN xref: Reactome:R-HSA-5652195 "SORD oxidizes D-sorbitol to Fru" xref: RHEA:10160 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003940 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: MetaCyc:3.2.1.76-RXN xref: Reactome:R-HSA-1678716 "IDUA hydrolyses Heparan sulfate chain(1)" xref: Reactome:R-HSA-1793186 "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS" xref: Reactome:R-HSA-2090037 "IDUA hydrolyses Heparan sulfate chain(6)" xref: Reactome:R-HSA-2206299 "Defective IDUA does not hydrolyse Heparan sulfate chain(6)" xref: Reactome:R-HSA-9036037 "Defective IDUA does not hydrolyse Heparan sulfate chain(1)" xref: Reactome:R-HSA-9036041 "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003941 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: MetaCyc:4.3.1.17-RXN xref: RHEA:19169 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0003942 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN xref: RHEA:21588 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0003943 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: MetaCyc:3.1.6.12-RXN xref: Reactome:R-HSA-1606789 "ARSB hydrolyses DS" xref: Reactome:R-HSA-1793207 "ARSB hydrolyses C4S/C6S chains" xref: Reactome:R-HSA-2282889 "Defective ARSB does not hydrolyse C4S/C6S chains" xref: Reactome:R-HSA-9036065 "Defective ARSB does not hydrolyse DS" xref: Wikipedia:Arylsulfatase_B is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0003944 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0003945 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN xref: RHEA:17745 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003947 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: MetaCyc:2.4.1.92-RXN xref: Reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides" xref: RHEA:12588 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0003948 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11544] synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: KEGG_REACTION:R03421 xref: MetaCyc:3.5.1.26-RXN xref: RHEA:11544 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003949 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15469] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: KEGG_REACTION:R04640 xref: MetaCyc:PRIBFAICARPISOM-RXN xref: RHEA:15469 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0003950 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4" xref: Reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN" xref: Reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate" xref: Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate" xref: Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD" xref: Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)" xref: Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003951 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18629] synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: KEGG_REACTION:R00104 xref: MetaCyc:NAD-KIN-RXN xref: Reactome:R-HSA-197198 "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+" xref: Reactome:R-HSA-8955030 "NADK2 dimer phosphorylates NAD+ to NADP+" xref: RHEA:18629 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0003952 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: MetaCyc:NAD-SYNTH-GLN-RXN xref: Reactome:R-HSA-197271 "NADSYN1 hexamer amidates NAAD to NAD+" xref: RHEA:24384 xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003953 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847] synonym: "NAD nucleosidase activity" EXACT [] xref: Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose" xref: Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose" xref: RHEA:16301 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN xref: RHEA:11356 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003955 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2] synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN xref: UM-BBD_reactionID:r0227 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003956 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: MetaCyc:2.4.2.31-RXN xref: Reactome:R-HSA-1972385 "ADP-Ribosylation of HNP-1" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003957 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN] synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity is_a: GO:0015078 ! proton transmembrane transporter activity [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN xref: Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+" is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0003959 name: NADPH dehydrogenase activity namespace: molecular_function alt_id: GO:0008468 alt_id: GO:0016660 def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.1] synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN xref: Reactome:R-HSA-9018867 "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2" xref: Reactome:R-HSA-9018901 "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2" xref: Reactome:R-HSA-9027625 "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3" xref: Reactome:R-HSA-9027631 "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA" xref: Reactome:R-HSA-9027632 "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA" xref: UM-BBD_enzymeID:e0523 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003960 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN xref: Reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones" is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003961 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function alt_id: GO:0019282 def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. synonym: "4.2.99.9" RELATED [] synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [] synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN xref: RHEA:10048 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups relationship: part_of GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0003962 name: cystathionine gamma-synthase activity namespace: molecular_function alt_id: GO:0000505 def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN xref: RHEA:20397 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003963 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0003964 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:R-HSA-164504 "Synthesis of minus strand strong stop DNA (-sssDNA)" xref: Reactome:R-HSA-164520 "Minus strand DNA synthesis resumes" is_a: GO:0034061 ! DNA polymerase activity relationship: part_of GO:0006278 ! RNA-dependent DNA biosynthetic process [Term] id: GO:0003966 name: obsolete RNA-directed DNA polymerase, transposon encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. synonym: "RNA-directed DNA polymerase, transposon encoded" EXACT [] is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003967 name: obsolete RNA-directed DNA polymerase, group II intron encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. synonym: "RNA-directed DNA polymerase, group II intron encoded" EXACT [] is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003968 name: RNA-directed 5'-3' RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf] synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA-directed RNA polymerase activity" BROAD [] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:R-HSA-168280 "Priming and Initiation of Transcription" xref: Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination" xref: Reactome:R-HSA-192624 "cRNA Extension" xref: Reactome:R-HSA-192832 "Initiation of cRNA Synthesis" xref: Reactome:R-HSA-192851 "vRNA Extension" xref: Reactome:R-HSA-192916 "Initiation of vRNA Synthesis" is_a: GO:0034062 ! 5'-3' RNA polymerase activity relationship: part_of GO:0001172 ! transcription, RNA-templated [Term] id: GO:0003969 name: obsolete RNA editase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a biological process. synonym: "RNA editase activity" EXACT [] is_obsolete: true [Term] id: GO:0003972 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3] synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: MetaCyc:RNA-LIGASE-ATP-RXN xref: Reactome:R-HSA-5696816 "tRNA ligase complex ligates tRNA exons" is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0003973 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15] synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003974 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN xref: RHEA:20517 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN xref: Reactome:R-HSA-446191 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate" xref: Reactome:R-HSA-4549334 "Defective DPAGT1 does not transfer GlcNAc to DOLP" xref: RHEA:13289 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003976 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003977 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13509] synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: KEGG_REACTION:R00416 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN xref: Reactome:R-HSA-446204 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine" xref: RHEA:13509 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0003978 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: MetaCyc:UDPGLUCEPIM-RXN xref: Reactome:R-HSA-5610036 "Defective GALE does not epimerise UDP-Gal to UDP-Glc" xref: Reactome:R-HSA-70369 "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc" xref: RHEA:22168 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003979 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596] xref: EC:1.1.1.22 xref: KEGG_REACTION:R00286 xref: MetaCyc:UGD-RXN xref: Reactome:R-HSA-173597 "UDP-glucose is oxidised to UDP-glucuronate" xref: RHEA:23596 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003980 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1 xref: Reactome:R-HSA-548884 "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b" is_a: GO:0035251 ! UDP-glucosyltransferase activity relationship: part_of GO:0097359 ! UDP-glucosylation [Term] id: GO:0003983 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889] synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: KEGG_REACTION:R00289 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: Reactome:R-HSA-70286 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose" xref: RHEA:19889 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0003984 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: MetaCyc:ACETOLACTSYN-RXN xref: RHEA:20504 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0003985 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: Reactome:R-HSA-70844 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA" xref: Reactome:R-HSA-73916 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA" xref: Reactome:R-HSA-74181 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA" xref: Reactome:R-HSA-8848215 "ACAT2 condenses 2 Ac-CoA to form ACA-CoA" xref: RHEA:21036 xref: UM-BBD_enzymeID:e0144 is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0003986 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20289] synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: KEGG_REACTION:R00227 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN xref: Reactome:R-HSA-2066779 "Conversion of DHA-CoA to docosahexaenoic acid (DHA)" xref: Reactome:R-HSA-390304 "acetyl-CoA + H2O => acetate + CoASH" xref: RHEA:20289 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003987 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: Reactome:R-HSA-449911 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]" xref: Reactome:R-HSA-71735 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]" xref: Reactome:R-HSA-8875071 "ACSS3 ligates CoA to CH3COO-" xref: RHEA:23176 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003988 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA" xref: Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA" xref: Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA" xref: Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA" xref: Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA" xref: Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA" xref: Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA" xref: Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH" xref: RHEA:21564 xref: UM-BBD_reactionID:r1051 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0003989 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: Reactome:R-HSA-200555 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate" xref: Reactome:R-HSA-75851 "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" xref: Reactome:R-HSA-8876889 "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" xref: RHEA:11308 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: goslim_chembl synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN xref: Reactome:R-HSA-372519 "AcCho is hydrolyzed to Cho and acetate by ACHE" xref: RHEA:17561 is_a: GO:0004104 ! cholinesterase activity [Term] id: GO:0003991 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8] synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: MetaCyc:ACETYLGLUTKIN-RXN xref: RHEA:14629 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0003992 name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity namespace: molecular_function alt_id: GO:0047318 def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18049] synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" BROAD [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: KEGG_REACTION:R02283 xref: MetaCyc:ACETYLORNTRANSAM-RXN xref: RHEA:18049 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: Reactome:R-HSA-196950 "2xTRAP hydrolyzes FMN to RIB" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: Reactome:R-HSA-450975 "isocitrate <=> citrate" xref: Reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT" xref: Reactome:R-HSA-70971 "citrate <=> isocitrate" xref: RHEA:10336 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003995 name: acyl-CoA dehydrogenase activity namespace: molecular_function alt_id: GO:0019109 def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.3 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN xref: Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA" xref: Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA" xref: Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2" xref: Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2" xref: Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2" xref: Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2" xref: Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2" xref: Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2" xref: Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2" xref: Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2" xref: Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0003996 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22." [EC:6.2.1.3, GOC:mah] xref: EC:6.2.1.3 xref: Reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA" is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003997 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: MetaCyc:ACYL-COA-OXIDASE-RXN xref: Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)" xref: Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" xref: Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA" xref: Reactome:R-HSA-390256 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0003998 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: MetaCyc:ACYLPHOSPHATASE-RXN xref: RHEA:14965 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0003999 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: Reactome:R-HSA-74213 "Adenine + PRPP => AMP + PPi" xref: RHEA:16609 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0004000 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: MetaCyc:ADENODEAMIN-RXN xref: Reactome:R-HSA-2161187 "N6-methyl-AMP + H2O => IMP + methylamine" xref: Reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine" xref: Reactome:R-HSA-5693346 "CECRI deaminates Ade-Rib to Ino" xref: Reactome:R-HSA-74241 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)" xref: RHEA:24408 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004001 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: Reactome:R-HSA-109624 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)" xref: RHEA:20824 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity relationship: part_of GO:0006167 ! AMP biosynthetic process [Term] id: GO:0004005 name: obsolete plasma membrane cation-transporting ATPase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "plasma membrane cation-transporting ATPase" EXACT [] is_obsolete: true consider: GO:0005886 consider: GO:0019829 [Term] id: GO:0004007 name: obsolete heavy metal-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal-exporting ATPase activity" EXACT [] is_obsolete: true consider: GO:0046873 [Term] id: GO:0004009 name: obsolete ATP-binding cassette (ABC) transporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: goslim_chembl synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:R-HSA-174401 "AHCY:NAD+ tetramer hydrolyses AdoHcy" xref: Reactome:R-HSA-5579084 "Defective AHCY does not hydrolyse AdoHcy" xref: RHEA:21708 is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0004014 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15981] synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: KEGG_REACTION:R00178 xref: MetaCyc:SAMDECARB-RXN xref: Reactome:R-HSA-351222 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2" xref: RHEA:15981 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004015 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16861] synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: KEGG_REACTION:R03231 xref: MetaCyc:DAPASYN-RXN xref: RHEA:16861 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis" xref: Reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP" xref: Reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP" xref: Reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate" xref: Reactome:R-HSA-5211224 "Anthrax EF catalyzes the conversion of ATP to cAMP" xref: Reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner" xref: RHEA:15389 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: Reactome:R-HSA-110141 "(d)ADP + ADP <=> (d)AMP + ATP (AK1)" xref: Reactome:R-HSA-110144 "ADP + ADP <=> AMP + ATP [AK2]" xref: Reactome:R-HSA-110145 "AMP + ATP <=> ADP + ADP [AK2]" xref: Reactome:R-HSA-74220 "(d)AMP + ATP <=> (d)ADP + ADP (AK1)" xref: RHEA:12973 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004018 name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG_REACTION:R01083 xref: MetaCyc:AMPSYN-RXN xref: Reactome:R-HSA-73800 "SAICAR => AICAR + Fumarate" xref: Reactome:R-HSA-73828 "adenylosuccinate => adenosine 5'-monophosphate + fumarate" xref: RHEA:16853 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004019 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15753] synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: KEGG_REACTION:R01135 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: Reactome:R-HSA-111524 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]" xref: RHEA:15753 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004020 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: Reactome:R-HSA-174389 "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS" xref: Reactome:R-HSA-3560785 "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS" xref: RHEA:24152 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004021 name: L-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19453] synonym: "alanine aminotransferase activity" BROAD [] synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: KEGG_REACTION:R00258 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-507749 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]" xref: Reactome:R-HSA-507775 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]" xref: Reactome:R-HSA-70523 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]" xref: Reactome:R-HSA-70524 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]" xref: RHEA:19453 is_a: GO:0047635 ! alanine-oxo-acid transaminase activity [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] synonym: "aldo-keto reductase (NAD) activity" EXACT [] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+" xref: UM-BBD_enzymeID:e0023 is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity [Term] id: GO:0004023 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity [Term] id: GO:0004024 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] xref: Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+" is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity [Term] id: GO:0004025 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity [Term] id: GO:0004026 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL" xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004028 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] xref: Reactome:R-HSA-71260 "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT" xref: UM-BBD_enzymeID:e0432 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004029 name: aldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: MetaCyc:ALDHDEHYDROG-RXN xref: Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid" xref: Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate" xref: Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM" xref: Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH" xref: Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG" xref: Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG" xref: Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA" xref: Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]" xref: Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]" xref: RHEA:16185 xref: UM-BBD_enzymeID:e0024 xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0004030 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: Reactome:R-HSA-5692283 "ALD3A1 oxidises 4HPCP to CXPA" xref: Reactome:R-HSA-5696080 "ALDH3B1 oxidises HXAL to PALM" xref: Reactome:R-HSA-6808464 "ALDH3B2 oxidises HXAL to PALM" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN xref: Reactome:R-HSA-3204311 "AOX1 oxidises PXL to PDXate" xref: RHEA:16829 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004032 name: alditol:NADP+ 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] synonym: "aldehyde reductase activity" EXACT [EC:1.1.1.21] synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: KEGG_REACTION:R02820 xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: Reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol" xref: Reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol" is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0004033 name: aldo-keto reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] synonym: "aldo-keto reductase (NADP+) activity" EXACT [] synonym: "aldo-keto reductase activity" EXACT [] synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: Reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one" xref: Reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol" xref: Reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one" xref: Reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol" xref: Reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one" xref: Reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one" xref: Reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol" xref: Reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol" xref: Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol" xref: Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one" xref: Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one" xref: Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol" xref: Reactome:R-HSA-198845 "CYB5A:heme reduces SDA to VitC" xref: Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL" xref: Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH" xref: Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione" xref: Reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA" xref: Reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA" xref: Reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3" xref: Reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004034 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN xref: RHEA:10264 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004035 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: MetaCyc:ALKAPHOSPHA-RXN xref: Reactome:R-HSA-8878787 "ALPI dimer hydrolyses phosphate monoesters" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004037 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11016] synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: KEGG_REACTION:R02422 xref: MetaCyc:ALLANTOICASE-RXN xref: RHEA:11016 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004038 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: MetaCyc:ALLANTOINASE-RXN xref: RHEA:17029 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004039 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19029] synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: KEGG_REACTION:R00005 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN xref: RHEA:19029 xref: UM-BBD_reactionID:r0848 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004040 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004042 name: acetyl-CoA:L-glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24292] synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: KEGG_REACTION:R00259 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: Reactome:R-HSA-70542 "glutamate + acetyl CoA => N-acetyl glutamate + CoA" xref: RHEA:24292 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004044 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14905] synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: KEGG_REACTION:R01072 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: Reactome:R-HSA-73815 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate" xref: RHEA:14905 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004045 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function alt_id: GO:0019850 alt_id: GO:0019851 def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004046 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: MetaCyc:AMINOACYLASE-RXN xref: Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids" xref: Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids" xref: Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids" xref: RHEA:15565 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004047 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: MetaCyc:GCVT-RXN xref: Reactome:R-HSA-5693977 "AMT transfers NH2CH2 from GCSH:SAMDLL to THF" xref: RHEA:16945 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004048 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11768] synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: KEGG_REACTION:R01073 xref: MetaCyc:PRTRANS-RXN xref: RHEA:11768 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004049 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: MetaCyc:ANTHRANSYN-RXN xref: RHEA:21732 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004050 name: obsolete apyrase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. synonym: "apyrase activity" EXACT [] is_obsolete: true consider: GO:0017110 consider: GO:0017111 [Term] id: GO:0004051 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN xref: Reactome:R-HSA-265296 "Arachidonic acid is oxidised to 5S-HpETE by ALOX5" xref: Reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5" xref: Reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE" xref: Reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE" xref: Reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE" xref: Reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE" xref: Reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA" xref: Reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA" xref: Reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA" xref: Reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA" xref: Reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA" xref: Reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA" xref: Reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA" xref: Reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA" xref: Reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA" xref: Reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3" xref: Reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3" xref: Reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3" xref: Reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA" xref: Reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4" xref: Reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA" xref: Reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE" xref: Reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3" xref: RHEA:24751 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004052 name: arachidonate 12(S)-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10428] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: KEGG_REACTION:R01596 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN xref: Reactome:R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12" xref: Reactome:R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B" xref: Reactome:R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15" xref: Reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA" xref: Reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6" xref: Reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3" xref: Reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3" xref: RHEA:10428 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004053 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: MetaCyc:ARGINASE-RXN xref: Reactome:R-HSA-452036 "arginine + H2O => ornithine + urea [ARG2]" xref: Reactome:R-HSA-70569 "arginine + H2O => ornithine + urea [ARG1]" xref: RHEA:20569 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004054 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22940] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: KEGG_REACTION:R00554 xref: MetaCyc:ARGININE-KINASE-RXN xref: RHEA:22940 is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004055 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: MetaCyc:ARGSUCCINSYN-RXN xref: Reactome:R-HSA-70577 "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA" xref: RHEA:10932 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004056 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: MetaCyc:ARGSUCCINLYA-RXN xref: Reactome:R-HSA-70573 "argininosuccinate <=> fumarate + arginine" xref: RHEA:24020 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004057 name: arginyltransferase activity namespace: molecular_function alt_id: GO:0042172 def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups relationship: part_of GO:0016598 ! protein arginylation [Term] id: GO:0004058 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function alt_id: GO:0016400 def: "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" NARROW [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" NARROW [EC:4.1.1.28] xref: EC:4.1.1.28 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN xref: Reactome:R-HSA-209859 "Decarboxylation of 5-hydroxytryptophan forms serotonin" xref: Reactome:R-HSA-209924 "Dopa is decarboxylated to dopamine" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004059 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-209792 "N-acetylation of serotonin" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004060 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-174963 "NAT1 acetylation" xref: Reactome:R-HSA-174967 "NAT2 acetylation" xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004061 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: Reactome:R-HSA-71189 "AFMID hydrolyses NFK to L-KYN" xref: RHEA:13009 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: goslim_chembl synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-158468 "SULT1A1 dimer sulfonates PARA to PARA-SO4" xref: Reactome:R-HSA-158849 "Phenol can form a sulfate conjugate" xref: Reactome:R-HSA-158860 "SULT1A1 dimer sulfonates NHABP" xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS" xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004063 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004064 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN xref: UM-BBD_reactionID:r0757 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004065 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1] synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004066 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: MetaCyc:ASNSYNB-RXN xref: Reactome:R-HSA-70599 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]" xref: RHEA:24877 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004067 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: MetaCyc:ASPARAGHYD-RXN xref: Reactome:R-HSA-6797627 "ASPG hydrolyses L-Asn to L-Asp" xref: RHEA:21016 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004068 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 xref: RHEA:19497 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004069 name: L-aspartate:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" BROAD [] synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" RELATED [EC:2.6.1.1] xref: EC:2.6.1.1 xref: KEGG_REACTION:R00355 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]" xref: Reactome:R-HSA-70592 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]" xref: Reactome:R-HSA-70596 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]" xref: Reactome:R-HSA-70613 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]" xref: RHEA:21824 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004070 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20013] synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: KEGG_REACTION:R01397 xref: MetaCyc:ASPCARBTRANS-RXN xref: Reactome:R-HSA-73573 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate" xref: RHEA:20013 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004071 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: MetaCyc:ASNSYNA-RXN xref: RHEA:11372 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004072 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23776] synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: KEGG_REACTION:R00480 xref: MetaCyc:ASPARTATEKIN-RXN xref: RHEA:23776 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004073 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24284] synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: KEGG_REACTION:R02291 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24284 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004074 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN xref: Reactome:R-HSA-189384 "Biliverdin is reduced to bilirubin" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004075 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004076 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22060] synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: KEGG_REACTION:R01078 xref: MetaCyc:2.8.1.6-RXN xref: RHEA:22060 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004077 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004078 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004079 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004080 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN xref: Reactome:R-HSA-5696197 "NUDT2 hydrolyses GP4G to GTP, GMP" xref: RHEA:22484 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0004082 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN xref: Reactome:R-HSA-6798335 "BPGM dimer isomerises 1,3BPG to 2,3BPG" xref: RHEA:17765 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004083 name: bisphosphoglycerate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [RHEA:21904] synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" BROAD [] xref: KEGG_REACTION:R01516 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21904 is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0004084 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah] synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: Reactome:R-HSA-508179 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]" xref: Reactome:R-HSA-508189 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]" xref: Reactome:R-HSA-70723 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]" xref: Reactome:R-HSA-70724 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004085 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1] synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "ethylene reductase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1] xref: EC:1.3.8.1 xref: KEGG_REACTION:R01178 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0013 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0004086 name: obsolete carbamoyl-phosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] comment: This term was made obsolete because it is a grouping term based on name, rather than on function. synonym: "carbamoyl phosphate synthase activity" EXACT [] synonym: "carbamoyl-phosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0004087 consider: GO:0004088 [Term] id: GO:0004087 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10624] synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: KEGG_REACTION:R00149 xref: MetaCyc:6.3.4.16-RXN xref: Reactome:R-HSA-70555 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]" xref: RHEA:10624 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004088 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: MetaCyc:CARBPSYN-RXN xref: Reactome:R-HSA-73577 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate" xref: RHEA:24654 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004089 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: MetaCyc:CARBODEHYDRAT-RXN xref: Reactome:R-HSA-1237045 "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton" xref: Reactome:R-HSA-1237047 "Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton" xref: Reactome:R-HSA-1237059 "Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide" xref: Reactome:R-HSA-1237081 "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide" xref: Reactome:R-HSA-1475017 "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)" xref: Reactome:R-HSA-1475022 "Carbonic anhydrase dehydrates bicarbonate (cytosol)" xref: Reactome:R-HSA-1475025 "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)" xref: Reactome:R-HSA-1475026 "Carbonic anhydrase hydrates carbon dioxide (cytosol)" xref: Reactome:R-HSA-1475028 "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" xref: Reactome:R-HSA-1475032 "Carbonic anhydrase hydrates carbon dioxide (mitochondria)" xref: Reactome:R-HSA-1475435 "Carbonic anhydrase I/II hydrates carbon dioxide" xref: Reactome:R-HSA-1475436 "Carbonic anhydrase I/II dehydrates bicarbonate" xref: RHEA:10748 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004090 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN xref: Reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL" xref: RHEA:19257 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004092 name: carnitine O-acetyltransferase activity namespace: molecular_function alt_id: GO:0004093 alt_id: GO:0004094 def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21136] synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: KEGG_REACTION:R02396 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-390284 "propionyl-CoA + carnitine => propionylcarnitine + CoASH" xref: Reactome:R-HSA-390291 "acetyl-CoA + carnitine => acetylcarnitine + CoASH" xref: RHEA:21136 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004095 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN xref: Reactome:R-HSA-200406 "CPT1A,B transfers PALM to CAR" xref: Reactome:R-HSA-200410 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine" xref: RHEA:12661 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: MIPS_funcat:32.07.07.01 xref: Reactome:R-HSA-1222704 "KatG reduces H2O2" xref: Reactome:R-HSA-76031 "2 H2O2 => O2 + 2 H2O" xref: RHEA:20309 xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004097 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: MetaCyc:CATECHOL-OXIDASE-RXN xref: RHEA:21632 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0004098 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8] synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN xref: Reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004099 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: MetaCyc:CHITIN-DEACETYLASE-RXN xref: RHEA:10464 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0004100 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16] synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004102 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18821] synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: KEGG_REACTION:R01023 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-264622 "Cho is acetylated to AcCho by CHAT" xref: RHEA:18821 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12837] synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: KEGG_REACTION:R01021 xref: MetaCyc:CHOLINE-KINASE-RXN xref: Reactome:R-HSA-1483004 "Cho is phosphorylated to PCho by CHK dimer" xref: RHEA:12837 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: goslim_chembl synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: RHEA:21964 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004105 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: MetaCyc:2.7.7.15-RXN xref: Reactome:R-HSA-1483081 "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer" xref: RHEA:18997 is_a: GO:0070567 ! cytidylyltransferase activity relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004106 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13897] synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: KEGG_REACTION:R01715 xref: MetaCyc:CHORISMATEMUT-RXN xref: RHEA:13897 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004107 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21020] synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: KEGG_REACTION:R01714 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN xref: RHEA:21020 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: Reactome:R-HSA-70975 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA" is_a: GO:0036440 ! citrate synthase activity [Term] id: GO:0004109 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18257] synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: KEGG_REACTION:R03220 xref: MetaCyc:RXN0-1461 xref: Reactome:R-HSA-189421 "CPO transforms COPRO3 to PPGEN9" xref: RHEA:18257 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004110 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17861] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: KEGG_REACTION:R04165 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN xref: RHEA:17861 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004111 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17157] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: KEGG_REACTION:R01881 xref: MetaCyc:CREATINE-KINASE-RXN xref: Reactome:R-HSA-200318 "creatine + ATP => phosphocreatine + ADP [CKB,CKM]" xref: Reactome:R-HSA-200326 "creatine + ATP => phosphocreatine + ADP [CK octamer]" xref: RHEA:17157 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004112 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004113 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004114 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: MetaCyc:3.1.4.17-RXN xref: Reactome:R-HSA-162425 "p-S295-PDE3B hydrolyses cAMP to AMP" xref: RHEA:14653 is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004115 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4 xref: MetaCyc:RXN0-5038 xref: Reactome:R-HSA-111962 "cAMP hydrolysis by PDE 4" xref: Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases" xref: Reactome:R-HSA-9629675 "PDE3A,3B hydrolyses cAMP to AMP" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004117 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4 xref: Reactome:R-HSA-111955 "cAMP hydrolysis by Cam-PDE 1" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004118 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004119 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004121 name: cystathionine beta-lyase activity namespace: molecular_function alt_id: GO:0008799 def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN xref: RHEA:13965 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004122 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN xref: Reactome:R-HSA-1614524 "Cystathionine is formed from homocysteine and serine" xref: RHEA:10112 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004123 name: cystathionine gamma-lyase activity namespace: molecular_function alt_id: GO:0016225 def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918] synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1] synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1] synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: KEGG_REACTION:R01001 xref: MetaCyc:CYSTAGLY-RXN xref: Reactome:R-HSA-1614583 "Cleavage of cystathionine into cysteine" xref: RHEA:24918 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:2.5.1.47] comment: Note that this function was formerly 4.2.99.8. synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN xref: RHEA:14829 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups relationship: part_of GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0004125 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004126 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: MetaCyc:CYTIDEAM2-RXN xref: Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)" xref: Reactome:R-HSA-83677 "C4 deamination of cytidine" xref: RHEA:16069 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity relationship: part_of GO:0009972 ! cytidine deamination [Term] id: GO:0004127 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: MetaCyc:CMPKI-RXN is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004128 name: cytochrome-b5 reductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: Reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme" xref: Reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA" is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome c oxidase activity" EXACT [GOC:tb] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen" is_a: GO:0009055 ! electron transfer activity is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor [Term] id: GO:0004130 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004131 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: MetaCyc:CYTDEAM-RXN xref: RHEA:20605 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004132 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: Reactome:R-HSA-73596 "dCMP + H2O => dUMP + NH4+" xref: RHEA:22924 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004133 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732] subset: goslim_pir is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0005977 ! glycogen metabolic process [Term] id: GO:0004134 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: MetaCyc:AMYLOMALT-RXN xref: MetaCyc:RXN-1828 xref: MetaCyc:RXN-9023 xref: Reactome:R-HSA-71552 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004135 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732] synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: MetaCyc:3.2.1.33-RXN xref: Reactome:R-HSA-71593 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004136 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23452] synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: KEGG_REACTION:R02089 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN xref: RHEA:23452 is_a: GO:0019136 ! deoxynucleoside kinase activity relationship: part_of GO:0006170 ! dAMP biosynthetic process [Term] id: GO:0004137 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN xref: RHEA:20061 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004138 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19201] synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: KEGG_REACTION:R01967 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN xref: RHEA:19201 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004139 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12821] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: KEGG_REACTION:R01066 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN xref: Reactome:R-HSA-6787321 "DERA cleaves dR5P to GA3P and CH3CHO" xref: RHEA:12821 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004140 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18245] synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: KEGG_REACTION:R00130 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN xref: Reactome:R-HSA-196773 "COASY phosphorylates DP-CoA" xref: RHEA:18245 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004141 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15805] synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: KEGG_REACTION:R03182 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN xref: RHEA:15805 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004142 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: MetaCyc:RXN-5781 xref: Reactome:R-HSA-1482961 "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane" xref: Reactome:R-HSA-1482973 "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane" xref: RHEA:10308 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004143 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "CTP:diacylglycerol kinase activity" NARROW [] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: MetaCyc:DIACYLGLYKIN-RXN xref: Reactome:R-HSA-426240 "DAG kinase produces phosphatidic acid from DAG" xref: RHEA:10272 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-1482889 "DAG is acylated to TAG by DGAT1/2" xref: Reactome:R-HSA-549192 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]" xref: Reactome:R-HSA-75900 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]" xref: Reactome:R-HSA-8848580 "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG" xref: RHEA:10868 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0004145 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: MetaCyc:DIAMACTRANS-RXN xref: Reactome:R-HSA-351207 "Spermine => N-acetylated spermine" xref: Reactome:R-HSA-351208 "Spermidine => N-acetylated spermidine" xref: RHEA:25181 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004146 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN xref: Reactome:R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR" xref: RHEA:15009 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004147 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004148 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: MetaCyc:DIHYDLIPOXN-RXN xref: Reactome:R-HSA-1222412 "lpdC dimer reactivates dlaT" xref: Reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate" xref: RHEA:15045 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004149 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 is_a: GO:0016751 ! S-succinyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004150 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: MetaCyc:H2NEOPTERINALDOL-RXN xref: RHEA:10540 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004151 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24296] synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: KEGG_REACTION:R01993 xref: MetaCyc:DIHYDROOROT-RXN xref: Reactome:R-HSA-73571 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O" xref: RHEA:24296 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004152 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18073] synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2] synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2] synonym: "DHOdehase activity" EXACT [EC:1.3.5.2] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.5.2] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2] xref: EC:1.3.5.2 xref: KEGG_REACTION:R01868 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-73569 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol" xref: RHEA:18073 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0004153 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] {comment="DOI:10.1016/0020-1790(83)90018-5"} is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004154 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004155 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: MetaCyc:1.5.1.34-RXN xref: Reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004156 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: MetaCyc:H2PTEROATESYNTH-RXN xref: RHEA:19949 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004157 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: Reactome:R-HSA-73589 "5,6-dihydrouracil + H2O => beta-ureidopropionate" xref: Reactome:R-HSA-73618 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate" xref: RHEA:16121 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004158 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15441] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: RHEA:15441 is_a: GO:0004152 ! dihydroorotate dehydrogenase activity is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004159 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN xref: RHEA:20189 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004160 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN xref: RHEA:20936 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004161 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl diphosphate synthase" EXACT [] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: MetaCyc:GPPSYN-RXN xref: Reactome:R-HSA-191322 "Addition of isopentenyl pyrophosphate to DMAPP" xref: RHEA:22408 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004162 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0004163 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23732] synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: KEGG_REACTION:R01121 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: Reactome:R-HSA-191414 "MVD decarboxylates MVA5PP to IPPP" xref: RHEA:23732 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004164 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: MetaCyc:RXN-11370 xref: Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2" xref: RHEA:20145 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004165 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function alt_id: GO:0008461 def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: Reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA" xref: Reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA" xref: RHEA:23716 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004166 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0004101 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: MetaCyc:2.4.1.153-RXN xref: RHEA:14693 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004167 name: dopachrome isomerase activity namespace: molecular_function alt_id: GO:0048059 def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13041] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: KEGG_REACTION:R03673 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN xref: RHEA:13041 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004168 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: MetaCyc:DOLICHOL-KINASE-RXN xref: Reactome:R-HSA-446195 "DOLK phosphorylates DCHOL to DOLP" xref: Reactome:R-HSA-4755600 "Defective DOLK does not phosphorylate DCHOL" xref: RHEA:13133 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004169 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr] comment: Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: MetaCyc:2.4.1.109-RXN xref: Reactome:R-HSA-5615556 "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1" xref: Reactome:R-HSA-5615604 "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1" xref: Reactome:R-HSA-5615637 "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)" is_a: GO:0000030 ! mannosyltransferase activity relationship: part_of GO:0035269 ! protein O-linked mannosylation [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: goslim_chembl synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: KEGG_REACTION:R02100 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate" xref: RHEA:10248 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0004171 name: obsolete deoxyhypusine synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] comment: This term was made obsolete because it represents a multistep reaction. synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] synonym: "deoxyhypusine synthase activity" EXACT [] is_obsolete: true consider: GO:0008612 consider: GO:0034038 [Term] id: GO:0004172 name: obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" EXACT [] is_obsolete: true consider: GO:0050488 [Term] id: GO:0004173 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15217] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: KEGG_REACTION:R02375 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN xref: RHEA:15217 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004174 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2" is_a: GO:0009055 ! electron transfer activity is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "elastase activity" RELATED [GOC:krc] synonym: "endoprotease activity" NARROW [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" NARROW [] xref: MetaCyc:RXN0-5195 xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded" xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha" xref: Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate" xref: Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen" xref: Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex" xref: Reactome:R-HSA-1433374 "Processing of SCF isoform 1" xref: Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome" xref: Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1" xref: Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins" xref: Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin" xref: Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1" xref: Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A" xref: Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4" xref: Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G" xref: Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome" xref: Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2" xref: Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain" xref: Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex" xref: Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34" xref: Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome" xref: Reactome:R-HSA-2213200 "Release of endostatin-like peptides" xref: Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1" xref: Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex" xref: Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome" xref: Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2" xref: Reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed" xref: Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome" xref: Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome" xref: Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome" xref: Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors" xref: Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage" xref: Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome" xref: Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome" xref: Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex" xref: Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB" xref: Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor" xref: Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome" xref: Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP" xref: Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH" xref: Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome" xref: Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome" xref: Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome" xref: Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3" xref: Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK" xref: Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome" xref: Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)" xref: Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome" xref: Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome" xref: Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome" xref: Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A" xref: Reactome:R-HSA-74730 "Insulin degradation" xref: Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1" xref: Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin" xref: Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN" xref: Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53" xref: Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7" xref: Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7" xref: Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome" xref: Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome" xref: Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin" xref: Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2" xref: Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome" xref: Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH" xref: Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2" xref: Reactome:R-HSA-9008475 "Proteasome degrades polyubiquitinated RUNX2" xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2" xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)" xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1" xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4" xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate" xref: Reactome:R-HSA-983158 "Trimming of peptides in ER" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] xref: EC:3.4.11 xref: MetaCyc:RXN0-5052 xref: Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles" xref: Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1" xref: Reactome:R-HSA-8851929 "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41)" xref: Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004178 name: obsolete leucyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl aminopeptidase activity" EXACT [] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: MetaCyc:3.4.11.1-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004179 name: obsolete membrane alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] comment: This term was made obsolete because it represents a gene product. synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane alanyl aminopeptidase activity" EXACT [] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: MetaCyc:3.4.11.2-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] xref: Reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004181 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] xref: EC:3.4.17 xref: Reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)" xref: Reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)" xref: Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)" xref: Reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a" xref: Reactome:R-HSA-8866105 "CCPs deglutamylate tubulin" xref: Reactome:R-HSA-8955712 "TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin" xref: Reactome:R-HSA-9023159 "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))" xref: Reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0004182 name: obsolete carboxypeptidase A activity namespace: molecular_function alt_id: GO:0008731 def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase A activity" EXACT [] synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004183 name: obsolete carboxypeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase E activity" EXACT [] synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004184 name: obsolete lysine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] comment: This term was made obsolete because it represents a gene product. synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004185 name: serine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 xref: Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0004186 name: obsolete carboxypeptidase C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase C activity" EXACT [] synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] synonym: "deamidase" RELATED [EC:3.4.16.5] synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] xref: EC:3.4.16.5 xref: MetaCyc:3.4.16.5-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004187 name: obsolete carboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D activity" EXACT [] synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] synonym: "CPDW-II" RELATED [EC:3.4.16.6] synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] xref: EC:3.4.16.6 xref: MetaCyc:3.4.16.6-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004188 name: obsolete serine-type Pro-X carboxypeptidase activity namespace: molecular_function alt_id: GO:0008323 def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "PCP" RELATED [EC:3.4.16.2] synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "serine-type Pro-X carboxypeptidase activity" EXACT [] xref: EC:3.4.16.2 xref: MetaCyc:3.4.16.2-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004189 name: obsolete tubulinyl-Tyr carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] comment: This term was made obsolete because it represents a gene product. synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] synonym: "TTCPase activity" EXACT [EC:3.4.17.17] synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulinyl-Tyr carboxypeptidase activity" EXACT [] synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] xref: EC:3.4.17.17 xref: MetaCyc:3.4.17.17-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004190 name: aspartic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] synonym: "aspartate protease activity" NARROW [GOC:mah, GOC:vw] synonym: "aspartic endopeptidase activity" EXACT [] synonym: "aspartic protease activity" NARROW [] synonym: "aspartyl protease activity" NARROW [] synonym: "carboxyl protease activity" NARROW [] xref: EC:3.4.23 xref: Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" xref: Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" xref: Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: Reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: Reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: Reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants" xref: Reactome:R-HSA-373705 "Caspase cleavage of DCC" xref: Reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3" xref: Reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3" xref: Reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070001 ! aspartic-type peptidase activity [Term] id: GO:0004191 name: obsolete barrierpepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] comment: This term was made obsolete because it represents a gene product. synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "barrierpepsin activity" EXACT [] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] xref: EC:3.4.23.35 xref: MetaCyc:3.4.23.35-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004192 name: obsolete cathepsin D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D activity" EXACT [] xref: EC:3.4.23.5 xref: MetaCyc:3.4.23.5-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004193 name: obsolete cathepsin E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin E activity" EXACT [] synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "EMAP" RELATED [EC:3.4.23.34] synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] xref: EC:3.4.23.34 xref: MetaCyc:3.4.23.34-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004194 name: obsolete pepsin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] comment: This term was made obsolete because it represents a gene product. synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] synonym: "P I" RELATED [EC:3.4.23.1] synonym: "P II" RELATED [EC:3.4.23.1] synonym: "pepsin A activity" EXACT [] synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] xref: EC:3.4.23.1 xref: MetaCyc:3.4.23.1-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004195 name: obsolete renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] comment: This term was made obsolete because it represents a gene product. synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] synonym: "renin activity" EXACT [] xref: EC:3.4.23.15 xref: MetaCyc:3.4.23.15-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004196 name: obsolete saccharopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] comment: This term was made obsolete because it represents a gene product. synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] synonym: "PRA" RELATED [EC:3.4.23.25] synonym: "proteinase A" RELATED [EC:3.4.23.25] synonym: "proteinase yscA" RELATED [EC:3.4.23.25] synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "saccharopepsin activity" EXACT [] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] xref: EC:3.4.23.25 xref: MetaCyc:3.4.23.25-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "caspase activity" NARROW [GOC:mtg_apoptosis] synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome" xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9" xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome" xref: Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle" xref: Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage" xref: Reactome:R-HSA-139952 "Caspase-8 processing in the DISC" xref: Reactome:R-HSA-1678920 "TLR processing at low pH" xref: Reactome:R-HSA-1678981 "TLR9 processing at neutral pH" xref: Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1" xref: Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta" xref: Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin" xref: Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1" xref: Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin" xref: Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)" xref: Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau" xref: Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus" xref: Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3" xref: Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1" xref: Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin" xref: Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1" xref: Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2" xref: Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha" xref: Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3" xref: Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3" xref: Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1" xref: Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin" xref: Reactome:R-HSA-202947 "Caspase mediated cleavage of APC" xref: Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1" xref: Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55" xref: Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin" xref: Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin" xref: Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3" xref: Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)" xref: Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212" xref: Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta" xref: Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22" xref: Reactome:R-HSA-2130349 "Generation of CLIP from lip10" xref: Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10" xref: Reactome:R-HSA-2130706 "MHC class II antigen processing" xref: Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex" xref: Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A" xref: Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1" xref: Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC" xref: Reactome:R-HSA-350158 "LGMN degrades GC" xref: Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)" xref: Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)" xref: Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK" xref: Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk" xref: Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2" xref: Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin" xref: Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2" xref: Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31" xref: Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3" xref: Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1" xref: Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin" xref: Reactome:R-HSA-352268 "Cleavage of Satb1" xref: Reactome:R-HSA-418845 "Activation of caspase-3" xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A" xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B" xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1" xref: Reactome:R-HSA-5357828 "RIP1 is cleaved by CASP8" xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases" xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor" xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4" xref: Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4" xref: Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin" xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37" xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex" xref: Reactome:R-HSA-933532 "Processing of caspases" xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004198 name: calcium-dependent cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] synonym: "calpain activity" NARROW [] xref: Reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins" xref: Reactome:R-HSA-8863012 "Calpain cleaves p35 to p25" is_a: GO:0004197 ! cysteine-type endopeptidase activity [Term] id: GO:0004200 name: obsolete signaling (initiator) caspase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "signaling (initiator) caspase activity" EXACT [] synonym: "signalling (initiator) caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004201 name: obsolete caspase-1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-1 activity" EXACT [] synonym: "ICE" BROAD [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004202 name: obsolete caspase-2 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-2 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004203 name: obsolete caspase-4 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-4 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004204 name: obsolete caspase-5 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-5 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004205 name: obsolete caspase-8 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-8 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004206 name: obsolete caspase-10 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-10 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004207 name: obsolete effector caspase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "effector caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004208 name: obsolete caspase-3 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-3 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004209 name: obsolete caspase-6 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-6 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004210 name: obsolete caspase-7 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-7 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004211 name: obsolete caspase-9 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-9 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004212 name: obsolete lysosomal cysteine-type endopeptidase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "lysosomal cysteine-type endopeptidase" EXACT [] is_obsolete: true consider: GO:0004197 consider: GO:0005764 [Term] id: GO:0004213 name: obsolete cathepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin B activity" EXACT [] synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] xref: EC:3.4.22.1 xref: MetaCyc:3.4.22.1-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004214 name: obsolete dipeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] synonym: "DAP I" RELATED [EC:3.4.14.1] synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl-peptidase I activity" EXACT [] xref: EC:3.4.14.1 xref: MetaCyc:3.4.14.1-RXN is_obsolete: true consider: GO:0008234 consider: GO:0008239 [Term] id: GO:0004215 name: obsolete cathepsin H activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] comment: This term was made obsolete because it represents a gene product. synonym: "aleurain activity" EXACT [EC:3.4.22.16] synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "cathepsin H activity" EXACT [] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] xref: EC:3.4.22.16 xref: MetaCyc:3.4.22.16-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004216 name: obsolete cathepsin K activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin K activity" EXACT [] synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] xref: EC:3.4.22.38 xref: MetaCyc:3.4.22.38-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004217 name: obsolete cathepsin L activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] comment: This term was made obsolete because it represents a gene product. synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] synonym: "cathepsin L activity" EXACT [] xref: EC:3.4.22.15 xref: MetaCyc:3.4.22.15-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004218 name: obsolete cathepsin S activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin S activity" EXACT [] xref: EC:3.4.22.27 xref: MetaCyc:3.4.22.27-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004219 name: obsolete pyroglutamyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] comment: This term was made obsolete because it represents a gene product. synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "PYRase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl-peptidase I activity" EXACT [] synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] xref: EC:3.4.19.3 xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN is_obsolete: true consider: GO:0008234 consider: GO:0016920 [Term] id: GO:0004221 name: obsolete ubiquitin thiolesterase activity namespace: molecular_function alt_id: GO:0008577 def: "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] comment: This term was made obsolete because this molecular function does not exist. synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin thiolesterase activity" EXACT [] synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] xref: KEGG_REACTION:R02418 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_obsolete: true consider: GO:0004843 consider: GO:0036459 [Term] id: GO:0004222 name: metalloendopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "metalloendoprotease activity" NARROW [GOC:mah] synonym: "metalloendoproteinase activity" NARROW [GOC:mah] xref: EC:3.4.24 xref: Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR" xref: Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17" xref: Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors" xref: Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors" xref: Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" xref: Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2" xref: Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14" xref: Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14" xref: Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14" xref: Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13" xref: Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11" xref: Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13" xref: Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3" xref: Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12" xref: Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2" xref: Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10" xref: Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1" xref: Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9" xref: Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13" xref: Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs" xref: Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2" xref: Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF" xref: Reactome:R-HSA-181567 "BoNT/C LC cleaves target cell STX1" xref: Reactome:R-HSA-194793 "BoNT/C LC cleaves target cell SNAP25" xref: Reactome:R-HSA-194796 "BoNT/B LC cleaves target cell VAMP2" xref: Reactome:R-HSA-194800 "BoNT/E LC cleaves target cell SNAP25" xref: Reactome:R-HSA-194808 "BoNT/F LC cleaves target cell VAMP1" xref: Reactome:R-HSA-194809 "BoNT/D LC cleaves target cell VAMP1" xref: Reactome:R-HSA-194818 "BoNT/A LC cleaves target cell SNAP25" xref: Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides" xref: Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides" xref: Reactome:R-HSA-2022141 "Prolysyl oxidase activation" xref: Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12" xref: Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9" xref: Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF" xref: Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15" xref: Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15" xref: Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15" xref: Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13" xref: Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10" xref: Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13" xref: Reactome:R-HSA-2514790 "Elastin degradation by MMP14" xref: Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14" xref: Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14" xref: Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10" xref: Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6" xref: Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15" xref: Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7" xref: Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15" xref: Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7" xref: Reactome:R-HSA-2537499 "Gelatin degradation by MMP19" xref: Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1" xref: Reactome:R-HSA-3371385 "TNF-alpha is cleaved by ADAM17 (TACE)" xref: Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5" xref: Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19" xref: Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14" xref: Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13" xref: Reactome:R-HSA-3791319 "NID1 degradation by MMP19" xref: Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4" xref: Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS" xref: Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7" xref: Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14" xref: Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7" xref: Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)" xref: Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15" xref: Reactome:R-HSA-5228578 "TeNT LC cleaves target cell VAMP2" xref: Reactome:R-HSA-5250606 "BoNT/D LC cleaves target cell VAMP2" xref: Reactome:R-HSA-5250892 "BoNT/F LC cleaves target cell VAMP2" xref: Reactome:R-HSA-5250962 "BoNT/G LC cleaves target cell VAMP2" xref: Reactome:R-HSA-5250978 "BoNT/G LC cleaves target cell VAMP1" xref: Reactome:R-HSA-5333671 "CLCAs self cleave" xref: Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding" xref: Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3" xref: Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)" xref: Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1" xref: Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2" xref: Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3" xref: Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1" xref: Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4" xref: Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3" xref: Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)" xref: Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)" xref: Reactome:R-HSA-8940554 "MMP2 cleaves OPTC" xref: Reactome:R-HSA-8940561 "MMP7 cleaves OPTC" xref: Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)" xref: Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin" xref: Reactome:R-HSA-8942302 "MMP13 cleaves OPTC" xref: Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3" xref: Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)" xref: Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU" xref: Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1" xref: Reactome:R-HSA-9624272 "MMPs cleave HB-EGF" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008237 ! metallopeptidase activity [Term] id: GO:0004226 name: obsolete Gly-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] synonym: "Gly-X carboxypeptidase activity" EXACT [] synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] xref: EC:3.4.17.4 xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004228 name: obsolete gelatinase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] comment: This term was made obsolete because it represents a gene product. synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] synonym: "collagenase IV" RELATED [EC:3.4.24.24] synonym: "collagenase type IV" RELATED [EC:3.4.24.24] synonym: "gelatinase A activity" EXACT [] synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] synonym: "MMP 2" RELATED [EC:3.4.24.24] synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] xref: EC:3.4.24.24 xref: MetaCyc:3.4.24.24-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004229 name: obsolete gelatinase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] comment: This term was made obsolete because it represents a gene product. synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] synonym: "collagenase IV" RELATED [EC:3.4.24.35] synonym: "collagenase type IV" RELATED [EC:3.4.24.35] synonym: "gelatinase B activity" EXACT [] synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] xref: EC:3.4.24.35 xref: MetaCyc:3.4.24.35-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004230 name: obsolete glutamyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "glutamyl aminopeptidase activity" EXACT [] synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] xref: EC:3.4.11.7 xref: MetaCyc:3.4.11.7-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004231 name: obsolete insulysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] comment: This term was made obsolete because it represents a gene product. synonym: "IDE" RELATED [EC:3.4.24.56] synonym: "insulin protease activity" EXACT [EC:3.4.24.56] synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "insulysin activity" EXACT [] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] xref: EC:3.4.24.56 xref: MetaCyc:3.4.24.56-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004232 name: obsolete interstitial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] comment: This term was made obsolete because it represents a gene product. synonym: "interstitial collagenase activity" EXACT [] synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] xref: EC:3.4.24.7 xref: MetaCyc:3.4.24.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004234 name: obsolete macrophage elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] comment: This term was made obsolete because it represents a gene product. synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] synonym: "macrophage elastase activity" EXACT [] synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] synonym: "metalloesterase activity" EXACT [] synonym: "MMP-12" EXACT [] xref: EC:3.4.24.65 xref: MetaCyc:3.4.24.65-RXN is_obsolete: true consider: GO:0004175 consider: GO:0004222 [Term] id: GO:0004235 name: obsolete matrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] comment: This term was made obsolete because it represents a gene product. synonym: "matrilysin activity" EXACT [] synonym: "matrin activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] synonym: "MMP" RELATED [EC:3.4.24.23] synonym: "MMP 7" RELATED [EC:3.4.24.23] synonym: "MMP-7" EXACT [] synonym: "PUMP" RELATED [EC:3.4.24.23] synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] xref: EC:3.4.24.23 xref: MetaCyc:3.4.24.23-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004237 name: obsolete membrane dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] comment: This term was made obsolete because it represents a gene product. synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] synonym: "DPH I activity" NARROW [EC:3.4.13.19] synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "MDP" RELATED [EC:3.4.13.19] synonym: "membrane dipeptidase activity" EXACT [] synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] xref: EC:3.4.13.19 xref: MetaCyc:3.4.13.19-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0004238 name: obsolete meprin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] comment: This term was made obsolete because it represents a gene product. synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] synonym: "meprin" RELATED [EC:3.4.24.18] synonym: "meprin A activity" EXACT [] synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] xref: EC:3.4.24.18 xref: MetaCyc:3.4.24.18-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004239 name: obsolete methionyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] comment: This term was made obsolete because it represents a gene product. synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "MAP" RELATED [EC:3.4.11.18] synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "methionyl aminopeptidase activity" EXACT [] synonym: "peptidase M activity" EXACT [EC:3.4.11.18] xref: EC:3.4.11.18 xref: MetaCyc:3.4.11.18-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 consider: GO:0070084 [Term] id: GO:0004240 name: obsolete mitochondrial processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" NARROW [] synonym: "beta-mitochondrial processing peptidase" NARROW [] synonym: "matrix peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] synonym: "mitochondrial processing peptidase activity" EXACT [] synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] xref: EC:3.4.24.64 xref: MetaCyc:3.4.24.64-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004241 name: obsolete alpha-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" EXACT [] synonym: "alpha-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004242 name: obsolete beta-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "beta-mitochondrial processing peptidase" EXACT [] synonym: "beta-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004243 name: obsolete mitochondrial intermediate peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] comment: This term was made obsolete because it represents a gene product. synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate peptidase activity" EXACT [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] xref: EC:3.4.24.59 xref: MetaCyc:3.4.24.59-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004244 name: obsolete mitochondrial inner membrane peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] comment: This term was made obsolete because it represents a gene product. synonym: "IMP" BROAD [] synonym: "mitochondrial inner membrane peptidase activity" EXACT [] xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0004245 name: obsolete neprilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] comment: This term was made obsolete because it represents a gene product. synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "CALLA" RELATED [EC:3.4.24.11] synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] synonym: "CALLA antigen" RELATED [EC:3.4.24.11] synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] synonym: "CD10" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] synonym: "neprilysin activity" EXACT [] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] xref: EC:3.4.24.11 xref: MetaCyc:3.4.24.11-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004246 name: obsolete peptidyl-dipeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] comment: This term was made obsolete because it represents a gene product. synonym: "ACE activity" BROAD [] synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] synonym: "DCP" RELATED [EC:3.4.15.1] synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] synonym: "kininase II activity" EXACT [EC:3.4.15.1] synonym: "PDH" RELATED [EC:3.4.15.1] synonym: "peptidase P activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyl-dipeptidase A activity" EXACT [] synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] xref: EC:3.4.15.1 xref: MetaCyc:3.4.15.1-RXN is_obsolete: true consider: GO:0008237 consider: GO:0008241 [Term] id: GO:0004247 name: obsolete saccharolysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] comment: This term was made obsolete because it represents a gene product. synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharolysin activity" EXACT [] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] xref: EC:3.4.24.37 xref: MetaCyc:3.4.24.37-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004248 name: obsolete stromelysin 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] comment: This term was made obsolete because it represents a gene product. synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] synonym: "MMP-3" EXACT [] synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "procollagenase activator" RELATED [EC:3.4.24.17] synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "stromelysin 1 activity" EXACT [] synonym: "transin activity" EXACT [EC:3.4.24.17] xref: EC:3.4.24.17 xref: MetaCyc:3.4.24.17-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004249 name: obsolete stromelysin 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] synonym: "stromelysin 3 activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004250 name: obsolete aminopeptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase I activity" EXACT [] synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] xref: EC:3.4.11.22 xref: MetaCyc:3.4.11.22-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004251 name: obsolete X-Pro dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] comment: This term was made obsolete because it represents a gene product. synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] synonym: "peptidase D" RELATED [EC:3.4.13.9] synonym: "prolidase activity" EXACT [EC:3.4.13.9] synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] synonym: "X-Pro dipeptidase activity" EXACT [] synonym: "Xaa-Pro dipeptidase activity" EXACT [] xref: EC:3.4.13.9 xref: MetaCyc:3.4.13.9-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: goslim_chembl synonym: "blood coagulation factor activity" RELATED [] synonym: "serine elastase activity" RELATED [GOC:krc] xref: EC:3.4.21 xref: Reactome:R-HSA-114697 "Thrombin-mediated activation of Proteinase-activated receptors" xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein" xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage" xref: Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides" xref: Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)" xref: Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide" xref: Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)" xref: Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)" xref: Reactome:R-HSA-140769 "factor VII -> factor VIIa" xref: Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)" xref: Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)" xref: Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B" xref: Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin" xref: Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form" xref: Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C" xref: Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin." xref: Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2" xref: Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases" xref: Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases" xref: Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS" xref: Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer" xref: Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)" xref: Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)" xref: Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin" xref: Reactome:R-HSA-158313 "factor XII -> factor XIIa" xref: Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)" xref: Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)" xref: Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin" xref: Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)" xref: Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin" xref: Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)" xref: Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)" xref: Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR" xref: Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)" xref: Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE" xref: Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2" xref: Reactome:R-HSA-1592297 "Full activation of MMP1" xref: Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)" xref: Reactome:R-HSA-1592316 "Initial activation of proMMP1" xref: Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3" xref: Reactome:R-HSA-1592371 "Initial activation of proMMP3" xref: Reactome:R-HSA-1592398 "Activation of proMMP8" xref: Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs" xref: Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin" xref: Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X" xref: Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C" xref: Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S" xref: Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX" xref: Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII" xref: Reactome:R-HSA-1602458 "Activation of proMMP10" xref: Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN" xref: Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1" xref: Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN" xref: Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin" xref: Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7" xref: Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14" xref: Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2" xref: Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs" xref: Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin" xref: Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases" xref: Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3" xref: Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13" xref: Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)" xref: Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3" xref: Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7" xref: Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z" xref: Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6" xref: Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2" xref: Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b" xref: Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b" xref: Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases" xref: Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by furin" xref: Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein" xref: Reactome:R-HSA-173626 "Activation of C1r" xref: Reactome:R-HSA-173631 "Activation of C1s" xref: Reactome:R-HSA-173680 "Activation of C5" xref: Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B" xref: Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase" xref: Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein" xref: Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B" xref: Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a" xref: Reactome:R-HSA-186785 "PDGF-AA clevage by Furin" xref: Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF" xref: Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH" xref: Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN" xref: Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-2129357 "Fibrillin C-terminal processing" xref: Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release" xref: Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding" xref: Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding" xref: Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1" xref: Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins" xref: Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding" xref: Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE" xref: Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2" xref: Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE" xref: Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS" xref: Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)" xref: Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1" xref: Reactome:R-HSA-265301 "Corticotropin cleavage from POMC" xref: Reactome:R-HSA-3266557 "Factor I cleaves iC3b" xref: Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG" xref: Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8" xref: Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)" xref: Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS" xref: Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1" xref: Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS" xref: Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1" xref: Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs" xref: Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB" xref: Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1" xref: Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP" xref: Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP" xref: Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin" xref: Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin" xref: Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound PA83 to yield PA63" xref: Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound PA83 to yield PA63" xref: Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)" xref: Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va" xref: Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa" xref: Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein" xref: Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer" xref: Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer" xref: Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer" xref: Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)" xref: Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP" xref: Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5" xref: Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2" xref: Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8" xref: Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5" xref: Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)" xref: Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin" xref: Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin" xref: Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4" xref: Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3" xref: Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2" xref: Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3" xref: Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1" xref: Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))" xref: Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)" xref: Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH" xref: Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS" xref: Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1" xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1" xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2" xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1" xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4" xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b" xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b" xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008236 ! serine-type peptidase activity [Term] id: GO:0004253 name: obsolete gamma-renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] comment: This term was made obsolete because it represents a gene product. synonym: "gamma-renin activity" EXACT [] xref: EC:3.4.21.54 xref: MetaCyc:3.4.21.54-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004254 name: obsolete acylaminoacyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] synonym: "acylaminoacyl-peptidase activity" EXACT [] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] xref: EC:3.4.19.1 xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004258 name: obsolete vacuolar carboxypeptidase Y namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it contains both component and function information. synonym: "vacuolar carboxypeptidase Y" EXACT [] is_obsolete: true consider: GO:0004185 consider: GO:0005773 [Term] id: GO:0004261 name: obsolete cathepsin G activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin G activity" EXACT [] synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] xref: EC:3.4.21.20 xref: MetaCyc:3.4.21.20-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004262 name: obsolete cerevisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] comment: This term was made obsolete because it represents a gene product. synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] synonym: "cerevisin activity" EXACT [] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] xref: EC:3.4.21.48 xref: MetaCyc:3.4.21.48-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004263 name: obsolete chymotrypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-chymar" RELATED [EC:3.4.21.1] synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] synonym: "avazyme" RELATED [EC:3.4.21.1] synonym: "chymar" RELATED [EC:3.4.21.1] synonym: "chymotest" RELATED [EC:3.4.21.1] synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsin activity" EXACT [] synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] xref: EC:3.4.21.1 xref: MetaCyc:3.4.21.1-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004274 name: obsolete dipeptidyl-peptidase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] comment: This term was made obsolete because it represents a gene product. synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-peptidase IV activity" EXACT [] synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] synonym: "DPP IV activity" EXACT [EC:3.4.14.5] synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "pep X" RELATED [EC:3.4.14.5] synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] synonym: "X-PDAP" RELATED [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] xref: EC:3.4.14.5 xref: MetaCyc:3.4.14.5-RXN is_obsolete: true consider: GO:0008236 consider: GO:0008239 [Term] id: GO:0004275 name: obsolete enteropeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] comment: This term was made obsolete because it represents a gene product. synonym: "enterokinase activity" RELATED [EC:3.4.21.9] synonym: "enteropeptidase activity" EXACT [] xref: EC:3.4.21.9 xref: MetaCyc:3.4.21.9-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004276 name: obsolete furin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] comment: This term was made obsolete because it represents a gene product. synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] synonym: "furin activity" EXACT [] synonym: "PACE" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] xref: EC:3.4.21.75 xref: MetaCyc:3.4.21.75-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004277 name: obsolete granzyme A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] comment: This term was made obsolete because it represents a gene product. synonym: "CTLA3" RELATED [EC:3.4.21.78] synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] synonym: "granzyme A activity" EXACT [] synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] xref: EC:3.4.21.78 xref: MetaCyc:3.4.21.78-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004278 name: obsolete granzyme B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] comment: This term was made obsolete because it represents a gene product. synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] synonym: "CCPII" RELATED [EC:3.4.21.79] synonym: "CTLA1" RELATED [EC:3.4.21.79] synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme B activity" EXACT [] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] xref: EC:3.4.21.79 xref: MetaCyc:3.4.21.79-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004281 name: obsolete pancreatic elastase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] synonym: "pancreatic elastase II activity" EXACT [] xref: EC:3.4.21.71 xref: MetaCyc:3.4.21.71-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004283 name: obsolete plasmin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] comment: This term was made obsolete because it represents a gene product. synonym: "actase activity" EXACT [EC:3.4.21.7] synonym: "fibrinase activity" EXACT [EC:3.4.21.7] synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "plasmin activity" EXACT [] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] xref: EC:3.4.21.7 xref: MetaCyc:3.4.21.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004284 name: obsolete acrosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] comment: This term was made obsolete because it represents a gene product. synonym: "acrosin activity" EXACT [] synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] xref: EC:3.4.21.10 xref: MetaCyc:3.4.21.10-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004285 name: obsolete proprotein convertase 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] synonym: "proprotein convertase 1 activity" EXACT [] xref: EC:3.4.21.93 xref: MetaCyc:3.4.21.93-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004286 name: obsolete proprotein convertase 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] synonym: "proprotein convertase 2 activity" EXACT [] xref: EC:3.4.21.94 xref: MetaCyc:3.4.21.94-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004287 name: obsolete prolyl oligopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] comment: This term was made obsolete because it represents a gene product. synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl oligopeptidase activity" EXACT [] xref: EC:3.4.21.26 xref: MetaCyc:3.4.21.26-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004289 name: obsolete subtilase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "subtilase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004290 name: obsolete kexin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] comment: This term was made obsolete because it represents a gene product. synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 protease" NARROW [EC:3.4.21.61] synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] synonym: "kexin activity" EXACT [] synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] synonym: "protease KEX2" RELATED [EC:3.4.21.61] synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] xref: EC:3.4.21.61 xref: MetaCyc:3.4.21.61-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004291 name: obsolete subtilisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] comment: This term was made obsolete because it represents a gene product. synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] synonym: "alcalase activity" EXACT [EC:3.4.21.62] synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] synonym: "colistinase activity" EXACT [EC:3.4.21.62] synonym: "esperase activity" EXACT [EC:3.4.21.62] synonym: "genenase I" RELATED [EC:3.4.21.62] synonym: "kazusase activity" EXACT [EC:3.4.21.62] synonym: "maxatase activity" EXACT [EC:3.4.21.62] synonym: "opticlean" RELATED [EC:3.4.21.62] synonym: "orientase 10B" RELATED [EC:3.4.21.62] synonym: "protease S" RELATED [EC:3.4.21.62] synonym: "protease VIII" RELATED [EC:3.4.21.62] synonym: "protease XXVII" RELATED [EC:3.4.21.62] synonym: "protin A 3L" RELATED [EC:3.4.21.62] synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] synonym: "savinase activity" EXACT [EC:3.4.21.62] synonym: "SP 266" RELATED [EC:3.4.21.62] synonym: "subtilisin activity" EXACT [] synonym: "subtilisin BL" RELATED [EC:3.4.21.62] synonym: "subtilisin DY" RELATED [EC:3.4.21.62] synonym: "subtilisin E" RELATED [EC:3.4.21.62] synonym: "subtilisin GX" RELATED [EC:3.4.21.62] synonym: "subtilisin J" RELATED [EC:3.4.21.62] synonym: "subtilisin S41" RELATED [EC:3.4.21.62] synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] xref: EC:3.4.21.62 xref: MetaCyc:3.4.21.62-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004293 name: obsolete tissue kallikrein activity namespace: molecular_function alt_id: GO:0004279 def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.35] synonym: "callicrein" RELATED [EC:3.4.21.35] synonym: "depot-padutin" RELATED [EC:3.4.21.35] synonym: "dilminal D" RELATED [EC:3.4.21.35] synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] synonym: "glumorin" RELATED [EC:3.4.21.35] synonym: "kallidinogenase" BROAD [EC:3.4.21.35] synonym: "kallikrein" RELATED [EC:3.4.21.35] synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] synonym: "kininogenase" BROAD [EC:3.4.21.35] synonym: "kininogenin activity" RELATED [EC:3.4.21.35] synonym: "onokrein P" RELATED [EC:3.4.21.35] synonym: "padreatin" RELATED [EC:3.4.21.35] synonym: "padutin" RELATED [EC:3.4.21.35] synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "tissue kallikrein activity" EXACT [] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] xref: EC:3.4.21.35 xref: MetaCyc:3.4.21.35-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004294 name: obsolete tripeptidyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] comment: This term was made obsolete because it represents a gene product. synonym: "TPP" RELATED [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl-peptidase II activity" EXACT [] xref: EC:3.4.14.10 xref: MetaCyc:3.4.14.10-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0004295 name: obsolete trypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] synonym: "cocoonase activity" EXACT [EC:3.4.21.4] synonym: "parenzyme" RELATED [EC:3.4.21.4] synonym: "parenzymol" RELATED [EC:3.4.21.4] synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "trypsin activity" EXACT [] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] xref: EC:3.4.21.4 xref: MetaCyc:3.4.21.4-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004298 name: threonine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "26S protease" RELATED [EC:3.4.25] synonym: "alkaline protease" RELATED [EC:3.4.25] synonym: "ingensin" RELATED [EC:3.4.25] synonym: "large multicatalytic protease" NARROW [EC:3.4.25] synonym: "lens neutral proteinase" NARROW [EC:3.4.25] synonym: "MCP" RELATED [EC:3.4.25] synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] synonym: "prosome" RELATED [EC:3.4.25] synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] synonym: "threonine endopeptidase activity" EXACT [] synonym: "tricorn protease" NARROW [EC:3.4.25] synonym: "tricorn proteinase" NARROW [EC:3.4.25] xref: EC:3.4.25 is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070003 ! threonine-type peptidase activity [Term] id: GO:0004299 name: obsolete proteasome endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] comment: This term was made obsolete because it mentions a component term in the text string. synonym: "multicatalytic endopeptidase" RELATED [] synonym: "proteasome" RELATED [] synonym: "proteasome endopeptidase activity" EXACT [] synonym: "proteasome endopeptidase complex" RELATED [] is_obsolete: true consider: GO:0004175 consider: GO:0008233 [Term] id: GO:0004300 name: enoyl-CoA hydratase activity namespace: molecular_function alt_id: GO:0016510 def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] synonym: "ECH" RELATED [EC:4.2.1.17] synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA" xref: Reactome:R-HSA-70870 "methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA" xref: Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA" xref: Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA" xref: Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA" xref: Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA" xref: Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA" xref: Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA" xref: Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA" xref: RHEA:16105 xref: UM-BBD_enzymeID:e0014 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: Reactome:R-HSA-2161961 "EET(1) is hydrolysed to DHET(1) by EPHX2" xref: Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1" xref: Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1" xref: Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2" xref: Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4" xref: Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1" xref: Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2" xref: Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4" xref: Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1" xref: Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1" xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2" xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA" xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA" xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA" xref: UM-BBD_enzymeID:e0397 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004303 name: estradiol 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-HSD" RELATED [EC:1.1.1.62] synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] xref: EC:1.1.1.62 xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN xref: Reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1" xref: Reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1" xref: Reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)" xref: Reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b" xref: Reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004304 name: estrone sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrone sulphotransferase activity" EXACT [] synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] xref: EC:2.8.2.4 xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176664 "estrone + PAPS => estrone 3-sulfate + PAP" xref: RHEA:15973 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004305 name: ethanolamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069] synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] xref: EC:2.7.1.82 xref: KEGG_REACTION:R01468 xref: MetaCyc:ETHANOLAMINE-KINASE-RXN xref: Reactome:R-HSA-1483222 "ETA is phosphorylated to PETA by CHK/ETNK" xref: RHEA:13069 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004306 name: ethanolamine-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "ET" RELATED [EC:2.7.7.14] synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] xref: EC:2.7.7.14 xref: MetaCyc:2.7.7.14-RXN xref: Reactome:R-HSA-1483190 "PETA and CTP are condensed to CDP-ETA by PCY2" xref: RHEA:24592 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004307 name: ethanolaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "EPT" RELATED [EC:2.7.8.1] synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] xref: EC:2.7.8.1 xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN xref: Reactome:R-HSA-1482962 "CDP-ETA and DAG are converted to PE by CEPT1/EPT1" xref: RHEA:14596 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004308 name: exo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "sialidase activity" EXACT [EC:3.2.1.18] xref: EC:3.2.1.18 xref: MetaCyc:3.2.1.18-RXN xref: Reactome:R-HSA-1605723 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)" xref: Reactome:R-HSA-1605724 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)" xref: Reactome:R-HSA-1605768 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)" xref: Reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid" xref: Reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates" xref: Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates" xref: Reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates" xref: Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates" xref: Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates" is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0004309 name: exopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] synonym: "exopolypase activity" EXACT [EC:3.6.1.11] synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004310 name: farnesyl-diphosphate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:2.5.1.21-RXN xref: Reactome:R-HSA-191402 "Reduction of presqualene diphosphate to form squalene" xref: Reactome:R-HSA-191405 "Two FPP molecules dimerize to form presqualene diphosphate" is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0004311 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17653] comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: KEGG_REACTION:R02061 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: RHEA:17653 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004312 name: fatty acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN xref: Reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0004313 name: [acyl-carrier-protein] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] synonym: "ACAT activity" BROAD [EC:2.3.1.38] synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP S-acetyltransferase activity" EXACT [] synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0004314 name: [acyl-carrier-protein] S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] synonym: "ACP S-malonyltransferase activity" EXACT [] synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "FabD" RELATED [EC:2.3.1.39] synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "MAT" RELATED [EC:2.3.1.39] synonym: "MCAT activity" EXACT [EC:2.3.1.39] xref: EC:2.3.1.39 xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN xref: Reactome:R-HSA-8933547 "MCAT transfers Mal from Mal-CoA to NDUFAB1" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016419 ! S-malonyltransferase activity [Term] id: GO:0004315 name: 3-oxoacyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] synonym: "3-oxoacyl-ACP synthase activity" EXACT [] synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "FabB" RELATED [EC:2.3.1.41] synonym: "FabF1" RELATED [EC:2.3.1.41] synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "KAS I activity" NARROW [EC:2.3.1.41] synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0004316 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "3-oxoacyl-ACP reductase activity" EXACT [] synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] xref: EC:1.1.1.100 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN xref: Reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004317 name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59] synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [] {comment="EC:4.2.1.59"} synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [] {comment="EC:4.2.1.59"} synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [] {comment="EC:4.2.1.59"} synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] {comment="EC:4.2.1.59"} synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] {comment="EC:4.2.1.59"} synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [] {comment="EC:4.2.1.59"} synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] xref: EC:4.2.1.59 xref: KEGG_REACTION:R04462 xref: MetaCyc:4.2.1.61-RXN xref: RHEA:13097 is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0004318 name: enoyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] xref: EC:1.3.1.9 xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004319 name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] xref: EC:1.3.1.10 xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004320 name: oleoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "oleoyl-ACP hydrolase activity" EXACT [] synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0004321 name: fatty-acyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] synonym: "fatty acyl CoA synthase activity" EXACT [] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0004322 name: ferroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferroxidase I" RELATED [EC:1.16.3.1] synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] xref: EC:1.16.3.1 xref: MetaCyc:RXN0-1483 xref: Reactome:R-HSA-1562603 "BfrB stores iron" xref: Reactome:R-HSA-1562604 "BfrA stores iron" xref: Reactome:R-HSA-1562626 "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)" xref: Reactome:R-HSA-5621402 "Defective CP does not oxidise Fe2+ to Fe3+" xref: Reactome:R-HSA-5691107 "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)" xref: Reactome:R-HSA-917891 "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+" xref: Reactome:R-HSA-917933 "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+" xref: RHEA:11148 is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor [Term] id: GO:0004323 name: obsolete multicopper ferroxidase iron transport mediator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "multicopper ferroxidase iron transport mediator activity" EXACT [] is_obsolete: true consider: GO:0004322 consider: GO:0005381 [Term] id: GO:0004324 name: ferredoxin-NADP+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-NADP reductase activity" EXACT [] synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: MetaCyc:1.18.1.2-RXN is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity [Term] id: GO:0004325 name: ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22584] synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] synonym: "heme synthase activity" EXACT [EC:4.99.1.1] synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] xref: EC:4.99.1.1 xref: KEGG_REACTION:R00310 xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN xref: Reactome:R-HSA-189465 "FECH binds Fe2+ to PRIN9 to form heme" xref: RHEA:22584 is_a: GO:0016829 ! lyase activity [Term] id: GO:0004326 name: tetrahydrofolylpolyglutamate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamate synthase activity" EXACT [] synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "FPGS activity" EXACT [EC:6.3.2.17] synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] xref: EC:6.3.2.17 xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN xref: Reactome:R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate" xref: Reactome:R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate" xref: Reactome:R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate" is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0046901 ! tetrahydrofolylpolyglutamate biosynthetic process [Term] id: GO:0004327 name: obsolete formaldehyde dehydrogenase (glutathione) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. synonym: "formaldehyde dehydrogenase (glutathione) activity" EXACT [] is_obsolete: true consider: GO:0051903 consider: GO:0051907 [Term] id: GO:0004328 name: formamidase activity namespace: molecular_function alt_id: GO:0034566 def: "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21948] synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] synonym: "formamide hydrolase activity" EXACT [] xref: EC:3.5.1.49 xref: KEGG_REACTION:R00524 xref: MetaCyc:FORMAMIDASE-RXN xref: RHEA:21948 xref: UM-BBD_reactionID:r0873 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004329 name: formate-tetrahydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw] synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] xref: EC:6.3.4.3 xref: MetaCyc:FORMATETHFLIG-RXN xref: Reactome:R-HSA-200711 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate" xref: Reactome:R-HSA-5696839 "MTHFD1L ligates HCOOH to THF to form 10-formyl-THF" xref: Reactome:R-HSA-6801456 "MTHFD1L transforms 10-formyl-THF to HCOOH and THF" xref: RHEA:20221 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004331 name: fructose-2,6-bisphosphate 2-phosphatase activity namespace: molecular_function alt_id: GO:0004330 def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46] synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] xref: EC:3.1.3.46 xref: MetaCyc:3.1.3.46-RXN xref: Reactome:R-HSA-5628905 "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate" xref: Reactome:R-HSA-70262 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate" xref: RHEA:17289 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0004332 name: fructose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13] synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "aldolase activity" BROAD [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "SMALDO" RELATED [EC:4.1.2.13] synonym: "zymohexase activity" EXACT [EC:4.1.2.13] xref: EC:4.1.2.13 xref: MetaCyc:F16ALDOLASE-RXN xref: Reactome:R-HSA-71495 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate" xref: Reactome:R-HSA-71496 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate" xref: RHEA:14729 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004333 name: fumarate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12460] synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] synonym: "fumarase activity" EXACT [EC:4.2.1.2] synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] xref: EC:4.2.1.2 xref: KEGG_REACTION:R01082 xref: MetaCyc:FUMHYDR-RXN xref: Reactome:R-HSA-451033 "(S)-Malate <=> Fumarate + H2O" xref: Reactome:R-HSA-70982 "Fumarate + H2O <=> (S)-Malate" xref: RHEA:12460 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004334 name: fumarylacetoacetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10244] synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] xref: EC:3.7.1.2 xref: KEGG_REACTION:R01364 xref: MetaCyc:FUMARYLACETOACETASE-RXN xref: Reactome:R-HSA-71181 "fumarylacetoacetate => fumarate + acetoacetate" xref: RHEA:10244 xref: UM-BBD_reactionID:r0107 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0004335 name: galactokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13553] synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] xref: EC:2.7.1.6 xref: KEGG_REACTION:R01092 xref: MetaCyc:GALACTOKIN-RXN xref: Reactome:R-HSA-5610026 "Defective GALK1 does not phosphorylate Gal" xref: Reactome:R-HSA-70355 "GALK1 phosphorylates Gal to Gal1P" xref: RHEA:13553 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004336 name: galactosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galcerase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] xref: EC:3.2.1.46 xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN xref: Reactome:R-HSA-1606564 "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide" xref: RHEA:14297 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004337 name: geranyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19361] comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] synonym: "farnesyl-diphosphate synthase activity" EXACT [] synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] xref: EC:2.5.1.10 xref: KEGG_REACTION:R02003 xref: MetaCyc:FPPSYN-RXN xref: Reactome:R-HSA-191303 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate" xref: Reactome:R-HSA-8870469 "RGGT geranylgeranylates RAB proteins" xref: RHEA:19361 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004338 name: glucan exo-1,3-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58] synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah] xref: EC:3.2.1.58 xref: MetaCyc:3.2.1.58-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0004339 name: glucan 1,4-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released. synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] synonym: "glucoamylase activity" EXACT [] synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] xref: EC:3.2.1.3 xref: MetaCyc:3.2.1.3-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004340 name: glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2] synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] xref: EC:2.7.1.2 xref: MetaCyc:GLUCOKIN-RXN xref: Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P" xref: Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P" xref: Reactome:R-HSA-70420 "HK1,2,3,GCK phosphorylate Glc to form G6P" xref: RHEA:17825 is_a: GO:0004396 ! hexokinase activity relationship: part_of GO:0051156 ! glucose 6-phosphate metabolic process [Term] id: GO:0004341 name: gluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] synonym: "lactonase activity" BROAD [EC:3.1.1.17] xref: EC:3.1.1.17 xref: MetaCyc:GLUCONOLACT-RXN xref: RHEA:10440 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004342 name: glucosamine-6-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12172] comment: Note that this function was formerly EC:5.3.1.10. synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] xref: EC:3.5.99.6 xref: KEGG_REACTION:R00765 xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN xref: Reactome:R-HSA-6799604 "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P" xref: RHEA:12172 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004343 name: glucosamine 6-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10292] synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] xref: EC:2.3.1.4 xref: KEGG_REACTION:R02058 xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN xref: Reactome:R-HSA-449734 "Acetylation of glucosamine 6-phosphate to GlcNAc6P" xref: RHEA:10292 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004344 name: glucose dehydrogenase activity namespace: molecular_function alt_id: GO:0008708 def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [PMID:22027299] synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] xref: EC:1.1.99.10 xref: KEGG_REACTION:R00305 xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:24540 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004345 name: glucose-6-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] synonym: "6-phosphoglucose dehydrogenas" RELATED [] synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] synonym: "G6PD activity" EXACT [EC:1.1.1.49] synonym: "G6PDH" EXACT [] synonym: "GDH" RELATED [] synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] synonym: "Zwischenferment" RELATED [] synonym: "zwischenferment" RELATED [EC:1.1.1.49] xref: EC:1.1.1.49 xref: MetaCyc:GLU6PDEHYDROG-RXN xref: Reactome:R-HSA-70377 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+" xref: RHEA:15841 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004346 name: glucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16689] synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] xref: EC:3.1.3.9 xref: KEGG_REACTION:R00303 xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN xref: Reactome:R-HSA-3262512 "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)" xref: Reactome:R-HSA-3266566 "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)" xref: Reactome:R-HSA-3274540 "Defective G6PC does not hydrolyze glucose 6-phosphate" xref: Reactome:R-HSA-3282876 "Defective G6PC3 does not hydrolyze glucose 6-phosphate" xref: Reactome:R-HSA-71825 "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)" xref: RHEA:16689 is_a: GO:0050309 ! sugar-terminal-phosphatase activity [Term] id: GO:0004347 name: glucose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] xref: EC:5.3.1.9 xref: MetaCyc:PGLUCISOM-RXN xref: Reactome:R-HSA-70471 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate" xref: Reactome:R-HSA-70475 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate" xref: RHEA:11816 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004348 name: glucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] xref: EC:3.2.1.45 xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN xref: Reactome:R-HSA-1605591 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide" xref: Reactome:R-HSA-1861788 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)" xref: Reactome:R-HSA-1861789 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)" xref: RHEA:13269 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004349 name: glutamate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14877] synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] xref: EC:2.7.2.11 xref: KEGG_REACTION:R00239 xref: MetaCyc:GLUTKIN-RXN xref: RHEA:14877 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004350 name: glutamate-5-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0001513 def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19541] synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-phosphate reductase activity" EXACT [] synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamylphosphate reductase activity" EXACT [] synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] xref: EC:1.2.1.41 xref: KEGG_REACTION:R03313 xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN xref: RHEA:19541 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004351 name: glutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: MetaCyc:GLUTDECARBOX-RXN xref: Reactome:R-HSA-888572 "Synthesis of GABA by GAD1" xref: Reactome:R-HSA-888577 "Synthesis of GABA by GAD2" xref: RHEA:17785 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004352 name: glutamate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN xref: RHEA:15133 is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004353 name: glutamate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] xref: EC:1.4.1.3 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN xref: MetaCyc:GLUTAMATE-SYN2-PWY xref: Reactome:R-HSA-70589 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]" xref: Reactome:R-HSA-70600 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]" is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004354 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY xref: RHEA:11612 is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004355 name: glutamate synthase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15501] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] synonym: "GOGAT activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] synonym: "NADPH GOGAT" EXACT [] synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] xref: EC:1.4.1.13 xref: KEGG_REACTION:R00114 xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTAMATESYN-RXN xref: MetaCyc:GLUTSYN-PWY xref: RHEA:15501 is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor [Term] id: GO:0004356 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16169] synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: KEGG_REACTION:R00253 xref: MetaCyc:GLUTAMINESYN-RXN xref: Reactome:R-HSA-70606 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]" xref: RHEA:16169 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004357 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13285] synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: KEGG_REACTION:R00894 xref: MetaCyc:GLUTCYSLIG-RXN xref: Reactome:R-HSA-174367 "GCL ligates L-Glu to L-Cys" xref: Reactome:R-HSA-5602892 "Defective GCLC does not ligate L-Glu to L-Cys" xref: RHEA:13285 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004358 name: glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15349] synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] xref: EC:2.3.1.35 xref: KEGG_REACTION:R02282 xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN xref: RHEA:15349 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004359 name: glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] synonym: "glutaminase I" RELATED [EC:3.5.1.2] synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] xref: EC:3.5.1.2 xref: MetaCyc:GLUTAMIN-RXN xref: Reactome:R-HSA-70609 "glutamine + H2O => glutamate + NH4+ [GLS]" xref: RHEA:15889 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004360 name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13237] synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] xref: EC:2.6.1.16 xref: KEGG_REACTION:R00768 xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN xref: Reactome:R-HSA-4085027 "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P" xref: Reactome:R-HSA-449715 "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P" xref: RHEA:13237 is_a: GO:0070548 ! L-glutamine aminotransferase activity [Term] id: GO:0004361 name: glutaryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.8.6] synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.6] synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.8.6] synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.8.6] xref: EC:1.3.8.6 xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN xref: Reactome:R-HSA-71046 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2" xref: RHEA:13389 xref: UM-BBD_reactionID:r0198 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004362 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732] comment: Note that this function was formerly EC:1.6.4.2. synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: Reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" xref: Reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" xref: RHEA:11740 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004363 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13557] synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: KEGG_REACTION:R00497 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: Reactome:R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH" xref: Reactome:R-HSA-5602901 "Defective GSS does not synthesize GSH" xref: RHEA:13557 is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0006750 ! glutathione biosynthetic process [Term] id: GO:0004364 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: MetaCyc:GSHTRAN-RXN xref: MIPS_funcat:32.07.07.03 xref: Reactome:R-HSA-176054 "GST dimers conjugate GSH with cytosolic substrates" xref: Reactome:R-HSA-176059 "GST trimers transfer GS from GSH to luminal substrates" xref: Reactome:R-HSA-3301943 "GSTK1 dimer transfers GS from GSH to CDNB" xref: Reactome:R-HSA-5423653 "MGST trimers transfer GS from GSH to AFXBO and AFNBO" xref: Reactome:R-HSA-9026777 "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" xref: Reactome:R-HSA-9026780 "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" xref: Reactome:R-HSA-9026901 "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1" xref: Reactome:R-HSA-9026911 "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004365 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] synonym: "GAPDH activity" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] xref: EC:1.2.1.12 xref: MetaCyc:GAPOXNPHOSPHN-RXN xref: Reactome:R-HSA-70449 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+" xref: Reactome:R-HSA-70482 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+" xref: RHEA:10300 is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity [Term] id: GO:0004366 name: glycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] xref: EC:2.3.1.15 xref: MetaCyc:RXN-1381 xref: Reactome:R-HSA-1482695 "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)" xref: Reactome:R-HSA-549112 "G3P is acylated to 1-acyl LPA by AGPAT6" xref: Reactome:R-HSA-75886 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]" xref: RHEA:15325 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004367 name: glycerol-3-phosphate dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94] synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] xref: EC:1.1.1.8 xref: EC:1.1.1.94 xref: KEGG_REACTION:R00842 xref: MetaCyc:1.1.1.8-RXN xref: Reactome:R-HSA-75889 "DHAP is converted to G3P by GPD1/GPD1L" xref: RHEA:11092 is_a: GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004368 name: glycerol-3-phosphate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "glycerol-3-phosphate CoQ reductase" EXACT [EC:1.1.5.3] synonym: "glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.3] xref: EC:1.1.5.3 xref: MetaCyc:RXN-9927 xref: MetaCyc:RXN0-5260 xref: Reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)" xref: RHEA:18977 is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004369 name: glycerol-3-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18369] synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] xref: EC:1.1.3.21 xref: KEGG_REACTION:R00846 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN xref: RHEA:18369 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0004370 name: glycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21644] synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "GK" RELATED [EC:2.7.1.30] synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] xref: EC:2.7.1.30 xref: KEGG_REACTION:R00847 xref: MetaCyc:GLYCEROL-KIN-RXN xref: Reactome:R-HSA-75887 "Conversion of Glycerol to Glycerol-3-phosphate" xref: RHEA:21644 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004371 name: glycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15773] synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] xref: EC:2.7.1.29 xref: KEGG_REACTION:R01011 xref: MetaCyc:GLYCERONE-KINASE-RXN xref: RHEA:15773 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004372 name: glycine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] xref: EC:2.1.2.1 xref: MetaCyc:GLYOHMETRANS-RXN xref: Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine" xref: Reactome:R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine" xref: Reactome:R-HSA-5694137 "SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine" xref: Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly" xref: RHEA:15481 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004373 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] xref: EC:2.4.1.11 xref: MetaCyc:2.4.1.11-RXN xref: Reactome:R-HSA-3322001 "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" xref: Reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2" xref: Reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" xref: Reactome:R-HSA-3828061 "Defective GYS1 does not transfer glucose to growing glycogen chains" xref: Reactome:R-HSA-3858506 "Defective GYS2 does not transfer glucose to growing glycogen chains" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004374 name: obsolete glycine cleavage system namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] comment: This term was made obsolete because it represents a process rather than a function. synonym: "glycine cleavage system" EXACT [] synonym: "glycine synthase" BROAD [] is_obsolete: true replaced_by: GO:0019464 [Term] id: GO:0004375 name: glycine dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: MetaCyc:GCVP-RXN xref: Reactome:R-HSA-5693967 "GLDC dimer:2xPXLP decarboxylates Gly" is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] id: GO:0004376 name: glycolipid mannosyltransferase activity namespace: molecular_function alt_id: GO:0004580 def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] synonym: "glycolipid mannosyl transferase activity" EXACT [] xref: Reactome:R-HSA-162821 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" xref: Reactome:R-HSA-162873 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004377 name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] synonym: "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "glycolipid 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] xref: EC:2.4.1.131 xref: MetaCyc:2.4.1.131-RXN xref: RHEA:29523 is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004378 name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] synonym: "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity" EXACT systematic_synonym [EC:2.4.1.132] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "glycolipid 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] xref: EC:2.4.1.132 xref: MetaCyc:2.4.1.132-RXN xref: RHEA:29515 is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004379 name: glycylpeptide N-tetradecanoyltransferase activity namespace: molecular_function alt_id: GO:0019106 def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] synonym: "N-myristoyltransferase activity" EXACT [] synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] xref: EC:2.3.1.97 xref: MetaCyc:2.3.1.97-RXN xref: Reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2" xref: Reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1" is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0004380 name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] synonym: "A transferase activity" RELATED [EC:2.4.1.40] synonym: "A-transferase activity" EXACT [EC:2.4.1.40] synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] xref: EC:2.4.1.40 xref: MetaCyc:2.4.1.40-RXN xref: Reactome:R-HSA-9033959 "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC" xref: Reactome:R-HSA-9034042 "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec" is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0004381 name: fucosylgalactoside 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "B transferase activity" RELATED [EC:2.4.1.37] synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] xref: EC:2.4.1.37 xref: MetaCyc:2.4.1.37-RXN xref: Reactome:R-HSA-9033961 "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC" xref: Reactome:R-HSA-9034053 "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen" xref: RHEA:14349 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004382 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN xref: RHEA:22156 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004383 name: guanylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] synonym: "guanylyl cyclase activity" EXACT [] synonym: "receptor guanylate cyclase activity" NARROW [] xref: EC:4.6.1.2 xref: MetaCyc:GUANYLCYC-RXN xref: Reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP" xref: Reactome:R-HSA-74885 "GUCYs converts GTP to cGMP" xref: RHEA:13665 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity relationship: part_of GO:0006182 ! cGMP biosynthetic process [Term] id: GO:0004384 name: obsolete membrane-associated guanylate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "MAGUK" EXACT [] synonym: "membrane-associated guanylate kinase" EXACT [] is_obsolete: true consider: GO:0004385 consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0050839 [Term] id: GO:0004385 name: guanylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] synonym: "membrane-associated guanylate kinase" NARROW [] xref: EC:2.7.4.8 xref: MetaCyc:GUANYL-KIN-RXN xref: Reactome:R-HSA-110133 "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)" xref: Reactome:R-HSA-73788 "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)" xref: RHEA:20780 is_a: GO:0050145 ! nucleoside monophosphate kinase activity relationship: part_of GO:0046037 ! GMP metabolic process relationship: part_of GO:0046710 ! GDP metabolic process [Term] id: GO:0004386 name: helicase activity namespace: molecular_function alt_id: GO:0008026 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "ATP-dependent helicase activity" EXACT [] xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition" xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding" xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding" xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA" xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition" xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition" xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition" xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript" xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript" is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0004392 name: heme oxygenase (decyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.14.18] synonym: "haem oxidase activity" EXACT [EC:1.14.14.18] synonym: "haem oxygenase (decyclizing) activity" EXACT [] synonym: "haem oxygenase activity" EXACT [EC:1.14.14.18] synonym: "heme oxidase activity" EXACT [EC:1.14.14.18] synonym: "heme oxygenase activity" EXACT [EC:1.14.14.18] synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.14.18] synonym: "ORP33 proteins" RELATED [EC:1.14.14.18] xref: EC:1.14.14.18 xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN xref: Reactome:R-HSA-189398 "HMOX1,2 cleave heme" xref: RHEA:21764 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004394 name: heparan sulfate 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] synonym: "heparin 2-sulfotransferase activity" RELATED [] synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] xref: EC:2.8.2 xref: Reactome:R-HSA-2076508 "HS2ST1 sulfates IdoA at C2 in heparan sulfate" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0004395 name: hexaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] xref: EC:2.1.1.114 xref: MetaCyc:2.1.1.114-RXN xref: RHEA:14121 is_a: GO:0010420 ! 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [Term] id: GO:0004396 name: hexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] synonym: "hexokinase D" RELATED [EC:2.7.1.1] synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] xref: EC:2.7.1.1 xref: MetaCyc:HEXOKINASE-RXN xref: RHEA:22740 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004397 name: histidine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] synonym: "histidase activity" RELATED [GOC:hjd] synonym: "histidinase activity" RELATED [GOC:hjd] synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] xref: EC:4.3.1.3 xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN xref: Reactome:R-HSA-70899 "histidine => urocanate + NH4+" xref: RHEA:21232 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004398 name: histidine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] xref: EC:4.1.1.22 xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN xref: Reactome:R-HSA-977301 "Histidine is decarboxylated to histamine" xref: RHEA:20840 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004399 name: histidinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] xref: EC:1.1.1.23 xref: MetaCyc:HISTALDEHYD-RXN xref: MetaCyc:HISTOLDEHYD-RXN xref: RHEA:20641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004400 name: histidinol-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "histidinol-phosphate aminotransferase activity" EXACT [] synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] xref: EC:2.6.1.9 xref: MetaCyc:HISTAMINOTRANS-RXN xref: RHEA:23744 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004401 name: histidinol-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14465] synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "HPpase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] xref: EC:3.1.3.15 xref: KEGG_REACTION:R03013 xref: MetaCyc:HISTIDPHOS-RXN xref: RHEA:14465 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004402 name: histone acetyltransferase activity namespace: molecular_function alt_id: GO:0004403 alt_id: GO:0004404 alt_id: GO:0004405 alt_id: GO:0004406 alt_id: GO:0043166 alt_id: GO:0046971 def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] synonym: "H2A/H2B histone acetyltransferase activity" NARROW [] synonym: "H3/H4 histone acetyltransferase activity" NARROW [] synonym: "H4/H2 histone acetyltransferase activity" NARROW [] synonym: "H4/H2A acetyltransferase activity" NARROW [] synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] synonym: "histone acetylase activity" EXACT [] synonym: "histone lysine acetyltransferase activity" EXACT [] synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48] xref: EC:2.3.1.48 xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-3301237 "KAT2 complexes acetylate histone H3" xref: Reactome:R-HSA-3301345 "Elongator complex acetylates replicative histone H3, H4" xref: Reactome:R-HSA-3318413 "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3" xref: Reactome:R-HSA-3318415 "ATF2 acetylates histone H2B, H4" xref: Reactome:R-HSA-3318486 "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3" xref: Reactome:R-HSA-3321805 "NSL acetylates histone H4" xref: Reactome:R-HSA-3321883 "MSL acetylates histone H4" xref: Reactome:R-HSA-3321975 "NuA4 complex acetylates histone H2A, HIST1H4" xref: Reactome:R-HSA-3451147 "KAT5 HAT complex acetylates TCF4 gene at histone H4" xref: Reactome:R-HSA-3662318 "Type B histone acetlytransferase complex acetylates histone H4" xref: Reactome:R-HSA-3662335 "EP300 acetylates histone H2A, H2B, H3, H4" xref: Reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4" xref: Reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4" xref: Reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4" xref: Reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9" is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity relationship: part_of GO:0016573 ! histone acetylation [Term] id: GO:0004407 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272] xref: EC:3.5.1.98 xref: MetaCyc:3.5.1.98-RXN xref: Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin" xref: Reactome:R-HSA-2545253 "Deacetylation of cohesin" xref: Reactome:R-HSA-3769447 "HDAC1/2 containing-complexes deacetylate histones" xref: Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone" xref: Reactome:R-HSA-3782637 "HDAC8 deacetylates histones" xref: Reactome:R-HSA-3782655 "HDAC10 deacetylates histone" xref: Reactome:R-HSA-427514 "eNoSC deacetylates histone H3" xref: Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3" xref: Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity relationship: part_of GO:0016575 ! histone deacetylation [Term] id: GO:0004408 name: holocytochrome-c synthase activity namespace: molecular_function def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004409 name: homoaconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15485] synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "HACN activity" EXACT [EC:4.2.1.36] synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "Lys4" RELATED [EC:4.2.1.36] synonym: "LysF" RELATED [EC:4.2.1.36] xref: EC:4.2.1.36 xref: KEGG_REACTION:R04371 xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN xref: RHEA:15485 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004410 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12929] comment: Note that this function was formerly EC:4.1.3.21. synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: KEGG_REACTION:R00271 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN xref: RHEA:12929 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004411 name: homogentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15449] synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] xref: EC:1.13.11.5 xref: KEGG_REACTION:R02519 xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN xref: Reactome:R-HSA-71164 "homogentisate + O2 => maleylacetoacetate" xref: RHEA:15449 xref: UM-BBD_reactionID:r0105 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004412 name: homoserine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] xref: EC:1.1.1.3 xref: MetaCyc:HOMOSERDEHYDROG-RXN xref: RHEA:15761 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004413 name: homoserine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13985] synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] synonym: "HSK" RELATED [EC:2.7.1.39] xref: EC:2.7.1.39 xref: KEGG_REACTION:R01771 xref: MetaCyc:HOMOSERKIN-RXN xref: RHEA:13985 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004414 name: homoserine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13701] synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] xref: EC:2.3.1.31 xref: KEGG_REACTION:R01776 xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN xref: RHEA:13701 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004415 name: hyalurononglucosaminidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] synonym: "hyaluronoglucosaminidase activity" EXACT [] synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] xref: EC:3.2.1.35 xref: MetaCyc:3.2.1.35-RXN xref: Reactome:R-HSA-1793209 "HYAL1 hydrolyses Chondroitin chains" xref: Reactome:R-HSA-2160874 "HYAL1 hydrolyses (HA)50" xref: Reactome:R-HSA-2160892 "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments" xref: Reactome:R-HSA-2318585 "Defective HYAL1 does not hydrolyse Chondroitin chains" xref: Reactome:R-HSA-5693356 "CEMIP hydrolyses HA" xref: Reactome:R-HSA-9036077 "Defective HYAL1 does not hydrolyse (HA)50" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004416 name: hydroxyacylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] xref: EC:3.1.2.6 xref: MetaCyc:GLYOXII-RXN xref: Reactome:R-HSA-6783221 "HAGH hydrolyses (R)-S-LGSH to GSH and LACT" xref: RHEA:25245 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004417 name: hydroxyethylthiazole kinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24212] synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] xref: EC:2.7.1.50 xref: KEGG_REACTION:R04448 xref: MetaCyc:THIAZOLSYN3-RXN xref: RHEA:24212 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004418 name: hydroxymethylbilane synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13185] comment: Note that this function was formerly EC:4.3.1.8. synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] xref: EC:2.5.1.61 xref: KEGG_REACTION:R00084 xref: MetaCyc:OHMETHYLBILANESYN-RXN xref: Reactome:R-HSA-189406 "4 PBGs bind to form HMB" xref: RHEA:13185 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004419 name: hydroxymethylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24404] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] xref: EC:4.1.3.4 xref: KEGG_REACTION:R01360 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN xref: Reactome:R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA" xref: Reactome:R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA" xref: RHEA:24404 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004420 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15989] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: KEGG_REACTION:R02082 xref: MetaCyc:1.1.1.34-RXN xref: Reactome:R-HSA-191352 "Reduction of HMG-CoA produces mevalonate" xref: RHEA:15989 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004421 name: hydroxymethylglutaryl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10188] comment: Note that this function was formerly EC:4.1.3.5. synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] xref: EC:2.3.3.10 xref: KEGG_REACTION:R01978 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN xref: Reactome:R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA" xref: Reactome:R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH" xref: RHEA:10188 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004422 name: hypoxanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] synonym: "HPRT" RELATED [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG_REACTION:R01132 xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN xref: Reactome:R-HSA-74215 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)" xref: RHEA:17973 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0004423 name: iduronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulphatase activity" EXACT [] synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] xref: EC:3.1.6.13 xref: MetaCyc:3.1.6.13-RXN xref: Reactome:R-HSA-1678650 "IDS hydrolyses Heparan sulfate chain(5)" xref: Reactome:R-HSA-1793182 "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)" xref: Reactome:R-HSA-2262743 "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)" xref: Reactome:R-HSA-9036046 "Defective IDS does not hydrolyse Heparan sulfate chain(5)" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004424 name: imidazoleglycerol-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11040] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] xref: EC:4.2.1.19 xref: KEGG_REACTION:R03457 xref: MetaCyc:IMIDPHOSDEHYD-RXN xref: RHEA:11040 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004425 name: indole-3-glycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] xref: EC:4.1.1.48 xref: MetaCyc:IGPSYN-RXN xref: RHEA:23476 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004427 name: inorganic diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24576] synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] xref: EC:3.6.1.1 xref: KEGG_REACTION:R00004 xref: MetaCyc:INORGPYROPHOSPHAT-RXN xref: Reactome:R-HSA-449937 "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]" xref: Reactome:R-HSA-6788912 "LHPP:Mg2+ dimer hydrolyses PPi" xref: Reactome:R-HSA-71732 "pyrophosphate + H2O => 2 orthophosphate [cytosolic]" xref: RHEA:24576 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004428 name: obsolete inositol or phosphatidylinositol kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. synonym: "inositol or phosphatidylinositol kinase activity" EXACT [] synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] is_obsolete: true consider: GO:0016307 consider: GO:0019140 consider: GO:0052742 consider: GO:0052813 [Term] id: GO:0004430 name: 1-phosphatidylinositol 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19877] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] synonym: "PI kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4K" BROAD [EC:2.7.1.67] synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] xref: EC:2.7.1.67 xref: KEGG_REACTION:R03361 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN xref: Reactome:R-HSA-1675780 "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane" xref: Reactome:R-HSA-1675813 "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane" xref: Reactome:R-HSA-1675883 "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane" xref: Reactome:R-HSA-1675974 "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane" xref: Reactome:R-HSA-1676185 "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane" xref: RHEA:19877 is_a: GO:0052742 ! phosphatidylinositol kinase activity [Term] id: GO:0004432 name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA namespace: molecular_function def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" EXACT [] is_obsolete: true consider: GO:0016308 [Term] id: GO:0004433 name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB namespace: molecular_function def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" EXACT [] is_obsolete: true consider: GO:0016308 [Term] id: GO:0004435 name: phosphatidylinositol phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] synonym: "phosphoinositide phospholipase C activity" EXACT [EC:3.1.4.11] synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] xref: EC:3.1.4.11 xref: KEGG_REACTION:R03435 xref: MetaCyc:3.1.4.11-RXN xref: Reactome:R-HSA-111879 "PIP2 hydrolysis" xref: Reactome:R-HSA-167686 "Active PLCG1 hydrolyses PIP2" xref: Reactome:R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane" xref: Reactome:R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane" xref: Reactome:R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane" xref: Reactome:R-HSA-202407 "PLC-gamma1 hydrolyses PIP2" xref: Reactome:R-HSA-2730847 "Hydrolysis of PIP2 by PLCG" xref: Reactome:R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2" xref: Reactome:R-HSA-622382 "PIP2 hydrolysis" xref: Reactome:R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate" xref: RHEA:23915 is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0004436 name: phosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] comment: Note that this function was formerly EC:3.1.4.10. synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] xref: EC:4.6.1.13 xref: MetaCyc:3.1.4.10-RXN xref: RHEA:17093 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004437 name: obsolete inositol or phosphatidylinositol phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. synonym: "inositol or phosphatidylinositol phosphatase activity" EXACT [] synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] is_obsolete: true consider: GO:0034593 consider: GO:0034594 consider: GO:0052744 consider: GO:0052745 [Term] id: GO:0004438 name: phosphatidylinositol-3-phosphatase activity namespace: molecular_function alt_id: GO:0016315 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] comment: Note that this function includes EC:3.1.3.65. synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] xref: EC:3.1.3.64 xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN xref: Reactome:R-HSA-1675795 "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane" xref: Reactome:R-HSA-1675994 "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane" xref: Reactome:R-HSA-1676114 "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane" xref: Reactome:R-HSA-1676141 "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane" xref: Reactome:R-HSA-6809325 "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane" xref: Reactome:R-HSA-6809720 "PI3P is dephosphorylated to PI by MTM1:MTMR12" xref: Reactome:R-HSA-6809777 "PI3P is dephosphorylated to PI by MTMR2:SBF1" xref: Reactome:R-HSA-6809975 "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane" xref: RHEA:12316 is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity [Term] id: GO:0004439 name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function alt_id: GO:0001668 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22764] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] synonym: "PI(4,5)P2 5-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PtdIns(4,5)P(2) 5-phosphatase activity" EXACT [EC:3.1.3.36, GOC:mah] synonym: "PtdIns(4,5)P2 5-phosphatase activity" EXACT [EC:3.1.3.36, GOC:mah] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] xref: EC:3.1.3.36 xref: KEGG_REACTION:R04404 xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN xref: Reactome:R-HSA-1675824 "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane" xref: Reactome:R-HSA-1676177 "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane" xref: Reactome:R-HSA-8868648 "SYNJ hydrolyze PI(4,5)P2 to PI(4)P" xref: RHEA:22764 is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity [Term] id: GO:0004441 name: inositol-1,4-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] xref: EC:3.1.3.57 xref: MetaCyc:3.1.3.57-RXN xref: Reactome:R-HSA-1855208 "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol" xref: RHEA:15553 is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0004442 name: obsolete inositol-1,4,-bisphosphate 3-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] synonym: "inositol-1,4,-bisphosphate 3-phosphatase" EXACT [] is_obsolete: true consider: GO:0004438 [Term] id: GO:0004443 name: obsolete inositol-1,4,-bisphosphate 4-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] synonym: "inositol-1,4,-bisphosphate 4-phosphatase" EXACT [] is_obsolete: true consider: GO:0016316 [Term] id: GO:0004444 name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase namespace: molecular_function def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] comment: This term was made obsolete because the existence of this function has not been established. synonym: "inositol-1,4,5-trisphosphate 1-phosphatase" EXACT [] is_obsolete: true consider: GO:0046030 [Term] id: GO:0004445 name: inositol-polyphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED [] synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56] synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] xref: EC:3.1.3.56 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0004446 name: inositol-hexakisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.62] synonym: "inositol tetrakisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.62] synonym: "MIPP activity" BROAD [EC:3.1.3.62] synonym: "multiple inositol-polyphosphate phosphatase activity" BROAD [EC:3.1.3.62] xref: EC:3.1.3.62 xref: MetaCyc:RXN-7920 is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0004447 name: iodide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8] synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] synonym: "iodinase activity" RELATED [EC:1.11.1.8] synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] synonym: "TPO activity" RELATED [EC:1.11.1.8] synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] xref: EC:1.11.1.8 xref: MetaCyc:IODIDE-PEROXIDASE-RXN xref: RHEA:23336 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004448 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: MetaCyc:ISOCITDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004449 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN xref: Reactome:R-HSA-70967 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]" xref: RHEA:23632 is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004450 name: isocitrate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] xref: EC:1.1.1.42 xref: MetaCyc:ISOCITDEH-RXN xref: Reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" xref: Reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" xref: Reactome:R-HSA-450984 "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]" xref: RHEA:19629 is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004451 name: isocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13245] synonym: "ICL activity" EXACT [EC:4.1.3.1] synonym: "isocitrase activity" EXACT [EC:4.1.3.1] synonym: "isocitratase activity" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] synonym: "isocitritase activity" EXACT [EC:4.1.3.1] synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] xref: EC:4.1.3.1 xref: KEGG_REACTION:R00479 xref: MetaCyc:ISOCIT-CLEAV-RXN xref: RHEA:13245 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004452 name: isopentenyl-diphosphate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23284] synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] xref: EC:5.3.3.2 xref: KEGG_REACTION:R01123 xref: MetaCyc:IPPISOM-RXN xref: Reactome:R-HSA-191382 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate" xref: RHEA:23284 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59] {comment="PMID:11267890"} subset: goslim_chembl synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN xref: RHEA:16393 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004454 name: ketohexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] xref: EC:2.7.1.3 xref: MetaCyc:KETOHEXOKINASE-RXN xref: Reactome:R-HSA-5656459 "Defective KHK does not phosphorylate beta-D-fructose" xref: Reactome:R-HSA-70333 "KHK dimer phosphorylates Fru to Fru 1-P" xref: RHEA:18145 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004455 name: ketol-acid reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004456 name: phosphogluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17277] synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] xref: EC:4.2.1.12 xref: KEGG_REACTION:R02036 xref: MetaCyc:PGLUCONDEHYDRAT-RXN xref: RHEA:17277 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004457 name: lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004458 name: D-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004459 name: L-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444] synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] xref: EC:1.1.1.27 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT" xref: Reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR" xref: Reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT" xref: RHEA:23444 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004460 name: L-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "cytochrome b2" RELATED [] synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004461 name: lactose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] xref: EC:2.4.1.22 xref: MetaCyc:LACTOSE-SYNTHASE-RXN xref: Reactome:R-HSA-5653878 "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac" xref: RHEA:12404 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004462 name: lactoylglutathione lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19069] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] synonym: "glyoxylase I" RELATED [EC:4.4.1.5] synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] xref: EC:4.4.1.5 xref: KEGG_REACTION:R02530 xref: MetaCyc:GLYOXI-RXN xref: Reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH" xref: RHEA:19069 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004463 name: leukotriene-A4 hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324] synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4H" RELATED [EC:3.3.2.6] xref: EC:3.3.2.6 xref: KEGG_REACTION:R03057 xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN xref: Reactome:R-HSA-266072 "LTA4 is hydolysed to LTB4 by LTA4H" xref: RHEA:22324 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004464 name: leukotriene-C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17617] comment: Note that this function was EC:2.5.1.37. synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] xref: EC:4.4.1.20 xref: KEGG_REACTION:R03059 xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN xref: Reactome:R-HSA-266050 "LTA4 is converted to LTC4 by LTC4S" xref: RHEA:17617 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004465 name: lipoprotein lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf] synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] xref: EC:3.1.1.34 xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN xref: Reactome:R-HSA-1482811 "DAG is hydrolyzed to 2-MAG by PNPLA2/3" xref: Reactome:R-HSA-174757 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols" xref: Reactome:R-HSA-2395768 "LPL hydrolyses TGs from mature CMs" xref: Reactome:R-HSA-6789310 "LIPs hydrolyse TG to DAG and RCOOH" xref: Reactome:R-HSA-8979996 "LIPs hydrolyze TG to DAG and LCFA" xref: Reactome:R-HSA-8980228 "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA" is_a: GO:0004806 ! triglyceride lipase activity [Term] id: GO:0004466 name: long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.8.8] synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.8] synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.8.8] synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.8.8] synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.8.8] synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.8] xref: EC:1.3.8.8 xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN xref: RHEA:17721 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004467 name: long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [EC:6.2.1.3] synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: Reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)" xref: Reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: Reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: Reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: Reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: Reactome:R-HSA-193711 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: Reactome:R-HSA-193727 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: Reactome:R-HSA-193743 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: Reactome:R-HSA-193766 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: Reactome:R-HSA-201035 "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA" xref: Reactome:R-HSA-2046085 "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA" xref: Reactome:R-HSA-2046098 "Activation of linoleic acid to linoleoyl-CoA" xref: Reactome:R-HSA-548843 "ACSL3,4 ligate CoA to AA to form AA-CoA" xref: UM-BBD_enzymeID:e0025 is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity relationship: part_of GO:0001676 ! long-chain fatty acid metabolic process [Term] id: GO:0004468 name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "LAT activity" EXACT [EC:2.3.1.32] synonym: "lysine acetyltransferase activity" EXACT [] synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] xref: EC:2.3.1.32 xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-5618328 "ATAT acetylates microtubules" xref: Reactome:R-HSA-5693001 "NAT8,8B acetylate BACE1" xref: RHEA:14417 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004470 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732] synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] is_a: GO:0016615 ! malate dehydrogenase activity [Term] id: GO:0004471 name: malate dehydrogenase (decarboxylating) (NAD+) activity namespace: molecular_function alt_id: GO:0004472 alt_id: GO:0016619 def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] synonym: "malate dehydrogenase (decarboxylating) activity" EXACT [EC:1.1.1.39] synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [] synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] xref: EC:1.1.1.38 xref: EC:1.1.1.39 xref: KEGG_REACTION:R00214 xref: MetaCyc:1.1.1.39-RXN xref: MetaCyc:MALIC-NAD-RXN xref: Reactome:R-HSA-9012268 "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: RHEA:12653 is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004473 name: malate dehydrogenase (decarboxylating) (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+." [EC:1.1.1.40] comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] xref: EC:1.1.1.40 xref: KEGG_REACTION:R00216 xref: MetaCyc:MALIC-NADP-RXN xref: Reactome:R-HSA-9012036 "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: Reactome:R-HSA-9012349 "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: RHEA:18253 is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004474 name: malate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18181] comment: Note that this function was formerly EC:4.1.3.2. synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] xref: EC:2.3.3.9 xref: KEGG_REACTION:R00472 xref: MetaCyc:MALSYN-RXN xref: RHEA:18181 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004475 name: mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15229] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] xref: EC:2.7.7.13 xref: KEGG_REACTION:R00885 xref: MetaCyc:2.7.7.13-RXN xref: Reactome:R-HSA-446221 "Mannose-1-phosphate converted to GDP-Mannose" xref: RHEA:15229 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0004476 name: mannose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] xref: EC:5.3.1.8 xref: MetaCyc:MANNPISOM-RXN xref: Reactome:R-HSA-3781832 "Defective MPI does not isomerize Fru6P to Man6P" xref: Reactome:R-HSA-532549 "MPI isomerises Fru6P to Man6P" xref: RHEA:12356 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004477 name: methenyltetrahydrofolate cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw] synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] xref: EC:3.5.4.9 xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN xref: Reactome:R-HSA-200661 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O" xref: Reactome:R-HSA-200740 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate" xref: Reactome:R-HSA-6801328 "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF" xref: RHEA:23700 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004478 name: methionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] xref: EC:2.5.1.6 xref: MetaCyc:S-ADENMETSYN-RXN xref: Reactome:R-HSA-174391 "MAT1A multimers transfer Ado from ATP to L-Met" xref: Reactome:R-HSA-5603087 "Defective MAT1A does not transfer Ado from ATP to L-Met" xref: Reactome:R-HSA-5603114 "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met" xref: RHEA:21080 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004479 name: methionyl-tRNA formyltransferase activity namespace: molecular_function alt_id: GO:0001718 alt_id: GO:0070128 def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] xref: EC:2.1.2.9 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN xref: Reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0006413 ! translational initiation relationship: part_of GO:0071951 ! conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [Term] id: GO:0004481 name: methylene-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: MetaCyc:2.1.1.16-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004482 name: mRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] xref: EC:2.1.1.56 xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping relationship: part_of GO:0106005 ! RNA 5'-cap (guanine-N7)-methylation [Term] id: GO:0004483 name: mRNA (nucleoside-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: MetaCyc:2.1.1.57-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004484 name: mRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] synonym: "protein lambda2" RELATED [EC:2.7.7.50] xref: EC:2.7.7.50 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex" xref: Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA" is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0004485 name: methylcrotonoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13589] synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "MCCC activity" EXACT [GOC:bf] synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] xref: EC:6.4.1.4 xref: KEGG_REACTION:R04138 xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN xref: Reactome:R-HSA-508308 "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]" xref: Reactome:R-HSA-70773 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]" xref: RHEA:13589 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004486 name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.15] synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw] synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: Reactome:R-HSA-200644 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+" xref: Reactome:R-HSA-200718 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004487 name: methylenetetrahydrofolate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22892] synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] xref: EC:1.5.1.15 xref: KEGG_REACTION:R01218 xref: MetaCyc:1.5.1.15-RXN xref: Reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF" xref: RHEA:22892 is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004488 name: methylenetetrahydrofolate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22812] synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: KEGG_REACTION:R01220 xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN xref: RHEA:22812 is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004489 name: methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: molecular_function alt_id: GO:0008702 def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: KEGG_REACTION:R01224 xref: KEGG_REACTION:R07168 xref: MetaCyc:1.5.1.20-RXN xref: Reactome:R-HSA-200676 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+" xref: RHEA:19817 xref: RHEA:19821 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004490 name: methylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21536] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] xref: EC:4.2.1.18 xref: KEGG_REACTION:R02085 xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN xref: Reactome:R-HSA-70785 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA" xref: RHEA:21536 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004491 name: methylmalonate-semialdehyde dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] synonym: "MSDH activity" EXACT [EC:1.2.1.27] xref: EC:1.2.1.27 xref: MetaCyc:1.2.1.27-RXN xref: Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+" xref: RHEA:20804 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004492 name: methylmalonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:7.2.4.3] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:7.2.4.3] synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:7.2.4.3] synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:7.2.4.3] synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:7.2.4.3] xref: EC:7.2.4.3 xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN xref: RHEA:21396 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004493 name: methylmalonyl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20553] synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] xref: EC:5.1.99.1 xref: KEGG_REACTION:R02765 xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN xref: Reactome:R-HSA-71020 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA" xref: RHEA:20553 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0004494 name: methylmalonyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22888] synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] xref: EC:5.4.99.2 xref: KEGG_REACTION:R00833 xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN xref: Reactome:R-HSA-3322971 "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA" xref: Reactome:R-HSA-71010 "MUT isomerises L-MM-CoA to SUCC-CoA" xref: RHEA:22888 xref: UM-BBD_reactionID:r0922 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004495 name: mevaldate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004496 name: mevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17065] synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] xref: EC:2.7.1.36 xref: KEGG_REACTION:R02245 xref: MetaCyc:MEVALONATE-KINASE-RXN xref: Reactome:R-HSA-191380 "Mevalonate is phosphorylated to mevalonate-5-phosphate" xref: RHEA:17065 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004497 name: monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732] subset: goslim_pir synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk] xref: Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde" xref: Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO" xref: Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone" xref: Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA" xref: Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation" xref: Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2" xref: Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA" xref: Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole" xref: Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide" xref: Reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b" xref: Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST" xref: Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA" xref: Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM" xref: Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL" xref: Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation" xref: Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6" xref: Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation" xref: Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole" xref: Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO" xref: Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4" xref: Reactome:R-HSA-2161795 "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)" xref: Reactome:R-HSA-2161814 "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)" xref: Reactome:R-HSA-2161890 "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)" xref: Reactome:R-HSA-2161899 "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)" xref: Reactome:R-HSA-2161940 "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)" xref: Reactome:R-HSA-2162191 "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase" xref: Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ" xref: Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E" xref: Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1" xref: Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO" xref: Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1" xref: Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA" xref: Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3" xref: Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3" xref: Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b" xref: Reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone" xref: Reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR" xref: Reactome:R-HSA-5663050 "DHI and DHICA polymerise forming eumelanin" xref: Reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE" xref: Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide" xref: Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl" xref: Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP" xref: Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol" xref: Reactome:R-HSA-76426 "N-atom dealkylation of caffeine" xref: Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical" xref: Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan" xref: Reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX" xref: Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2" xref: Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE" xref: Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1" xref: Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA" xref: Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2" xref: Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA" xref: Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA" xref: Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004498 name: calcidiol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.15.18, RHEA:20573] synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.15.18] synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.15.18] synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.15.18] synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [] synonym: "cytochrome P450 CYP27B" NARROW [] xref: EC:1.14.15.18 xref: KEGG_REACTION:R03610 xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN xref: Reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D" xref: Reactome:R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL" xref: RHEA:20573 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol [Term] id: GO:0004499 name: N,N-dimethylaniline monooxygenase activity namespace: molecular_function alt_id: GO:0047076 def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin-containing monooxygenase activity" BROAD [EC:1.13.12.11] synonym: "FMO activity" RELATED [EC:1.13.12.11] synonym: "FMO-I" RELATED [EC:1.13.12.11] synonym: "FMO-II" RELATED [EC:1.13.12.11] synonym: "FMO1" RELATED [EC:1.13.12.11] synonym: "FMO2" RELATED [EC:1.13.12.11] synonym: "FMO3" RELATED [EC:1.13.12.11] synonym: "FMO4" RELATED [EC:1.13.12.11] synonym: "FMO5" RELATED [EC:1.13.12.11] synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] xref: EC:1.14.13.8 xref: MetaCyc:1.14.13.8-RXN xref: Reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO" xref: Reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM" xref: Reactome:R-HSA-5602966 "Defective FMO3 does not N-oxidise TMA" xref: RHEA:24468 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004500 name: dopamine beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19117] synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine b-hydroxylase activity" EXACT [] synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] xref: EC:1.14.17.1 xref: KEGG_REACTION:R02535 xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN xref: Reactome:R-HSA-209891 "Dopamine is oxidised to noradrenaline" xref: RHEA:19117 is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004501 name: ecdysone 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14021] synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] synonym: "ecdysone 20-hydroxylase activity" EXACT [] synonym: "ecdysone modification" BROAD [] synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] xref: EC:1.14.99.22 xref: KEGG_REACTION:R02374 xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN xref: RHEA:14021 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004502 name: kynurenine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20545] synonym: "kynurenine 3-hydroxylase activity" EXACT [] synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] xref: EC:1.14.13.9 xref: KEGG_REACTION:R01960 xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN xref: Reactome:R-HSA-71200 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O" xref: RHEA:20545 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004503 name: monophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136] comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children. synonym: "catecholase" RELATED [EC:1.14.18.1] synonym: "chlorogenic acid oxidase activity" RELATED [EC:1.14.18.1] synonym: "chlorogenic oxidase activity" RELATED [EC:1.14.18.1] synonym: "cresolase activity" RELATED [EC:1.14.18.1] synonym: "dopa oxidase" RELATED [EC:1.14.18.1] synonym: "L-tyrosine monooxygenase activity" EXACT [GOC:bf] synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxygenase" EXACT [PMID:2494997] synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenolase activity" EXACT [EC:1.14.18.1] synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidase activity" RELATED [EC:1.14.18.1] synonym: "o-diphenol oxidoreductase" RELATED [EC:1.14.18.1] synonym: "o-diphenol:O2 oxidoreductase activity" RELATED [EC:1.14.18.1] synonym: "o-diphenol:oxygen oxidoreductase" RELATED [EC:1.14.18.1] synonym: "phenol oxidase activity" BROAD [] synonym: "phenolase activity" BROAD [EC:1.14.18.1] synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] synonym: "prophenol oxidase activity" RELATED [GOC:sart] synonym: "prophenoloxidase activity" RELATED [] synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] synonym: "tyrosinase activity" EXACT [EC:1.14.18.1] synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] xref: EC:1.14.18.1 xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN xref: RHEA:18117 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004504 name: peptidylglycine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] synonym: "PAM activity" EXACT [EC:1.14.17.3] synonym: "PAM-A" RELATED [EC:1.14.17.3] synonym: "PAM-B" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004505 name: phenylalanine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] synonym: "PAH activity" EXACT [EC:1.14.16.1] synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr" xref: Reactome:R-HSA-71118 "PAH tetramer hydroxylates L-Phe to L-Tyr" xref: RHEA:20273 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004506 name: squalene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)." [RHEA:25282] synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.14.17] synonym: "squalene epoxidase activity" EXACT [EC:1.14.14.17] synonym: "squalene hydroxylase activity" EXACT [EC:1.14.14.17] synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.14.17] synonym: "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity" EXACT [KEGG_REACTION:R02874] synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.14.17] synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.14.17] xref: EC:1.14.14.17 xref: KEGG_REACTION:R02874 xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN xref: Reactome:R-HSA-191299 "Squalene is oxidized to its epoxide" xref: RHEA:25282 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004507 name: steroid 11-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] synonym: "cytochrome P450 CYP11B1" NARROW [] synonym: "cytochrome P450 CYP11B2" NARROW [] synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] synonym: "steroid 11-beta-hydroxylase activity" EXACT [] synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] xref: EC:1.14.15.4 xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN xref: Reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT" xref: Reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST" xref: Reactome:R-HSA-5580292 "Defective CYP11B1 does not oxidise 11DCORT" xref: Reactome:R-HSA-5600598 "Defective CYP11B2 does not oxidise 11DCORST" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004508 name: steroid 17-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.14.19] synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.14.19] synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.14.19] synonym: "cytochrome P450 CYP17" NARROW [] synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.14.19] synonym: "cytochrome P45017alpha" RELATED [EC:1.14.14.19] synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.14.19] synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.14.19] synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.14.19] synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.14.19] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.14.19] xref: EC:1.14.14.19 xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN xref: Reactome:R-HSA-193068 "CYP17A1 17-hydroxylates PREG" xref: Reactome:R-HSA-193070 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA" xref: Reactome:R-HSA-193072 "CYP17A1 17-hydroxylates P4" xref: Reactome:R-HSA-193099 "CYP17A1 cleaves 17aHPROG to ANDST" xref: Reactome:R-HSA-5601843 "Defective CYP17A1 does not 17-hydroxylate PREG" xref: Reactome:R-HSA-9035954 "Defective CYP17A1 does not 17-hydroxylate P4" xref: Reactome:R-HSA-9035956 "Defective CYP17A1 does not cleave 17aHPROG" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004509 name: steroid 21-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.14.16] synonym: "21-hydroxylase activity" EXACT [EC:1.14.14.16] synonym: "cytochrome P450 CYP21A1" NARROW [] synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.14.16] synonym: "steroid 21-hydroxylase activity" EXACT [] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.14.16] xref: EC:1.14.14.16 xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN xref: Reactome:R-HSA-193964 "CYP21A2 21-hydroxylates PROG" xref: Reactome:R-HSA-193981 "CYP21A2 oxidises 17HPROG" xref: Reactome:R-HSA-5601976 "Defective CYP21A2 does not 21-hydroxylate PROG" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004510 name: tryptophan 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "L-tryptophan hydroxylase activity" EXACT [] synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] xref: EC:1.14.16.4 xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN xref: Reactome:R-HSA-209828 "Tryptophan is hydroxylated" xref: RHEA:16709 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004511 name: tyrosine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] synonym: "tyrosine 3-hydroxylase activity" EXACT [] synonym: "tyrosine hydroxylase activity" EXACT [] xref: EC:1.14.16.2 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN xref: Reactome:R-HSA-209823 "Tyrosine is hydroxylated to dopa" xref: RHEA:18201 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004512 name: inositol-3-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10716] synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] xref: EC:5.5.1.4 xref: KEGG_REACTION:R07324 xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN xref: Reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol" xref: RHEA:10716 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0004513 name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: MetaCyc:2.4.99.10-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0004514 name: nicotinate-nucleotide diphosphorylase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12733] synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] xref: EC:2.4.2.19 xref: KEGG_REACTION:R03348 xref: MetaCyc:QUINOPRIBOTRANS-RXN xref: Reactome:R-HSA-197268 "QPRT transfers PRIB to QUIN to form NAMN" xref: RHEA:12733 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004515 name: nicotinate-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] xref: EC:2.7.7.18 xref: MetaCyc:NICONUCADENYLYLTRAN-RXN xref: Reactome:R-HSA-197235 "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: Reactome:R-HSA-200474 "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: Reactome:R-HSA-200512 "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: RHEA:22860 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004516 name: nicotinate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:6.3.4.21, RHEA:13393] synonym: "niacin ribonucleotidase activity" EXACT [EC:6.3.4.21] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:6.3.4.21] xref: EC:6.3.4.21 xref: KEGG_REACTION:R01724 xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN xref: Reactome:R-HSA-197186 "NAPRT1 dimer transfers PRIB to NCA to form NAMN" xref: RHEA:13393 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004517 name: nitric-oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] synonym: "nitric oxide synthase activity" EXACT [] synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "NO synthase activity" EXACT [EC:1.14.13.39] xref: EC:1.14.13.39 xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN xref: Reactome:R-HSA-202127 "eNOS synthesizes NO" xref: Reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)" xref: RHEA:24668 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_plant subset: goslim_yeast is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0004519 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] xref: Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more" xref: Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch" xref: Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER" xref: Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends" xref: Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end" is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004520 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] synonym: "DNA nicking activity" RELATED [GOC:mah] synonym: "endonuclease G activity" RELATED [] xref: Reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site" xref: Reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop" xref: Reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA" xref: Reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ" xref: Reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER" xref: Reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)" xref: Reactome:R-HSA-5693608 "Initial resection of double-strand break ends" xref: Reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER" xref: Reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER" xref: Reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004521 name: endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] synonym: "endonuclease G activity" RELATED [] xref: Reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced" xref: Reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs" xref: Reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA" xref: Reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA" xref: Reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol" xref: Reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA" xref: Reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA" xref: Reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA" xref: Reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand" xref: Reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA" xref: Reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004540 ! ribonuclease activity relationship: part_of GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic [Term] id: GO:0004522 name: ribonuclease A activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.18] synonym: "alkaline ribonuclease activity" EXACT [] synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [] synonym: "endoribonuclease I" RELATED [] synonym: "gene S glycoproteins" RELATED [] synonym: "gene S locus-specific glycoproteins" RELATED [] synonym: "pancreatic ribonuclease activity" NARROW [] {comment="EC:4.6.1.18"} synonym: "pancreatic RNase activity" EXACT [EC:4.6.1.18] synonym: "ribonuclease I activity" EXACT [EC:4.6.1.18] synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [] synonym: "ribonucleic phosphatase activity" EXACT [] synonym: "RNase A activity" EXACT [EC:4.6.1.18] synonym: "RNase activity" BROAD [EC:4.6.1.18] synonym: "RNase I activity" EXACT [EC:4.6.1.18] synonym: "S-genotype-assocd. glycoproteins" RELATED [] synonym: "SLSG glycoproteins" RELATED [] xref: EC:4.6.1.18 xref: MetaCyc:3.1.27.5-RXN xref: Wikipedia:Ribonuclease_A is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004523 name: RNA-DNA hybrid ribonuclease activity namespace: molecular_function alt_id: GO:0004524 def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. synonym: "calf thymus ribonuclease H activity" EXACT [] synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] synonym: "hybridase activity" EXACT [EC:3.1.26.4] synonym: "ribonuclease H activity" EXACT [GOC:vw] synonym: "ribonuclease H1 activity" NARROW [] synonym: "ribonuclease H2 activity" NARROW [] synonym: "ribonuclease H3 activity" NARROW [] synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] synonym: "RNase H activity" EXACT [] synonym: "RNase H1 activity" NARROW [] synonym: "RNase H2 activity" NARROW [] synonym: "RNase H3 activity" NARROW [] xref: EC:3.1.26.4 xref: MetaCyc:3.1.26.4-RXN xref: Reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex" xref: Reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand" xref: Reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers" xref: Reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand" xref: Reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004525 name: ribonuclease III activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] synonym: "RNase III activity" EXACT [EC:3.1.26.3] xref: EC:3.1.26.3 xref: MetaCyc:3.1.26.3-RXN xref: Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA" xref: Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA" xref: Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters is_a: GO:0032296 ! double-stranded RNA-specific ribonuclease activity [Term] id: GO:0004526 name: ribonuclease P activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] synonym: "RNase P" EXACT [] synonym: "tRNA 5' leader endonuclease activity" EXACT [] xref: EC:3.1.26.5 xref: MetaCyc:3.1.26.5-RXN xref: Reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA" xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" xref: Wikipedia:RNase_P is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004527 name: exonuclease activity namespace: molecular_function alt_id: GO:0008857 def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] synonym: "exonuclease IX activity" NARROW [] is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004528 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: MetaCyc:3.1.4.1-RXN is_a: GO:0004527 ! exonuclease activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004529 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] is_a: GO:0004527 ! exonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004530 name: deoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] synonym: "DNAase activity" EXACT [EC:3.1.21.1] synonym: "DNase activity" NARROW [EC:3.1.21.1] synonym: "DNase I" RELATED [EC:3.1.21.1] synonym: "dornava" RELATED [EC:3.1.21.1] synonym: "dornavac" RELATED [EC:3.1.21.1] synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] xref: EC:3.1.21.1 xref: MetaCyc:3.1.21.1-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004531 name: deoxyribonuclease II activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] synonym: "acid DNase activity" EXACT [EC:3.1.22.1] synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] synonym: "DNase II activity" EXACT [EC:3.1.22.1] synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] xref: EC:3.1.22.1 xref: MetaCyc:3.1.22.1-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004532 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: Reactome:R-HSA-429961 "DCPS scavenges the 7-methylguanosine cap of mRNA" is_a: GO:0004527 ! exonuclease activity is_a: GO:0004540 ! ribonuclease activity relationship: part_of GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic [Term] id: GO:0004533 name: exoribonuclease H activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] xref: EC:3.1.13.2 xref: MetaCyc:3.1.13.2-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004534 name: 5'-3' exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: EC:3.1.13 xref: Reactome:R-HSA-429845 "5' to 3' exoribonuclease hydrolyzes decapped mRNA" is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004535 name: poly(A)-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4] synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "poly(A)-specific RNase activity" EXACT [] xref: EC:3.1.13.4 xref: MetaCyc:3.1.13.4-RXN xref: Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA" xref: Reactome:R-HSA-429992 "PARN deadenylates mRNA" xref: Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA" is_a: GO:0000175 ! 3'-5'-exoribonuclease activity [Term] id: GO:0004536 name: deoxyribonuclease activity namespace: molecular_function alt_id: GO:0004537 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] synonym: "caspase-activated deoxyribonuclease activity" NARROW [] xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" is_a: GO:0004518 ! nuclease activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0006259 ! DNA metabolic process [Term] id: GO:0004540 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] is_a: GO:0004518 ! nuclease activity is_a: GO:0140098 ! catalytic activity, acting on RNA relationship: part_of GO:0090501 ! RNA phosphodiester bond hydrolysis [Term] id: GO:0004549 name: tRNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] synonym: "tRNA-specific RNase activity" EXACT [] xref: Reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA" xref: Reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA" xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" is_a: GO:0004540 ! ribonuclease activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004550 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: Reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP" xref: Reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)" xref: Reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)" xref: Reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)" xref: Reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)" xref: Reactome:R-HSA-6806877 "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity relationship: part_of GO:0006165 ! nucleoside diphosphate phosphorylation [Term] id: GO:0004551 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN xref: Reactome:R-HSA-196955 "2xENPP1 hydrolyzes FAD to FMN" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004552 name: octanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24620] synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] xref: EC:1.1.1.73 xref: KEGG_REACTION:R02878 xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN xref: RHEA:24620 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004555 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: MetaCyc:TREHALA-RXN xref: Reactome:R-HSA-188985 "trehalose + H2O => 2 D-glucose" xref: RHEA:20868 is_a: GO:0015927 ! trehalase activity [Term] id: GO:0004556 name: alpha-amylase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1] synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] synonym: "endoamylase activity" EXACT [EC:3.2.1.1] synonym: "glycogenase activity" BROAD [EC:3.2.1.1] synonym: "taka-amylase A" RELATED [EC:3.2.1.1] xref: EC:3.2.1.1 xref: MetaCyc:ALPHA-AMYL-RXN xref: MetaCyc:RXN-1823 xref: MetaCyc:RXN-1825 xref: Reactome:R-HSA-188979 "Digestion of linear starch (amylose) by extracellular amylase" xref: Reactome:R-HSA-191114 "Digestion of branched starch (amylopectin) by extracellular amylase" is_a: GO:0016160 ! amylase activity [Term] id: GO:0004557 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN xref: Reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers" is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004558 name: alpha-1,4-glucosidase activity namespace: molecular_function alt_id: GO:0004562 alt_id: GO:0016982 def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: MetaCyc:MALTODEXGLUCOSID-RXN xref: Reactome:R-HSA-189053 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose" xref: Reactome:R-HSA-189102 "maltose + H2O => 2 D-glucose (maltase-glucoamylase)" xref: Reactome:R-HSA-191101 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)" xref: Reactome:R-HSA-191108 "maltose + H2O => 2 D-glucose (sucrase-isomaltase)" xref: Reactome:R-HSA-191116 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)" xref: Reactome:R-HSA-5659861 "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)" xref: Reactome:R-HSA-5659879 "Defective SI does not hydrolyze iMal" xref: Reactome:R-HSA-5659899 "Defective SI does not hydrolyze maltotriose" xref: Reactome:R-HSA-5659922 "Defective SI does not hydrolyze Mal" is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004559 name: alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] synonym: "1,2-alpha-D-mannosidase activity" NARROW [EC:3.2.1.24] synonym: "1,2-alpha-mannosidase" NARROW [EC:3.2.1.24] synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "p-nitrophenyl-alpha-mannosidase activity" NARROW [EC:3.2.1.24] xref: EC:3.2.1.24 xref: MetaCyc:3.2.1.24-RXN xref: Reactome:R-HSA-6799545 "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5" xref: Reactome:R-HSA-8853686 "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3" is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004560 name: alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN xref: Reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc" is_a: GO:0015928 ! fucosidase activity [Term] id: GO:0004561 name: alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "NAG activity" EXACT [EC:3.2.1.50] xref: EC:3.2.1.50 xref: MetaCyc:3.2.1.50-RXN xref: Reactome:R-HSA-1678742 "NAGLU hydrolyses Heparan sulfate chain(4)" xref: Reactome:R-HSA-2090038 "NAGLU hydrolyses heparan chain(2)" xref: Reactome:R-HSA-2263496 "Defective NAGLU does not hydrolyse Heparan sulfate chain(4)" xref: Reactome:R-HSA-9036052 "Defective NAGLU does not hydrolyse heparan chain(2)" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004563 name: beta-N-acetylhexosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] xref: EC:3.2.1.52 xref: MetaCyc:3.2.1.52-RXN xref: Reactome:R-HSA-1605595 "Hexosaminidase A cleaves GalNAc from GM2 to form GM3" xref: Reactome:R-HSA-1605632 "Both hexosaminidase A and B can cleave GalNAc from globoside" xref: Reactome:R-HSA-1638053 "HEXA cleaves the terminal GalNAc from keratan sulfate" xref: Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS" xref: Reactome:R-HSA-2162225 "HEXA cleaves the terminal GalNAc from small HA fragments" xref: Reactome:R-HSA-3656259 "Defective HEXA does not cleave the terminal GalNAc from DS" xref: Reactome:R-HSA-3662344 "Defective HEXB does not cleave the terminal GalNAc from DS" xref: Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments" xref: Reactome:R-HSA-9035978 "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate" xref: Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments" xref: Reactome:R-HSA-9035983 "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate" xref: Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS" xref: Reactome:R-HSA-9638076 "HEXB cleaves the terminal GalNAc from small HA fragments" xref: Reactome:R-HSA-9638078 "HEXB cleaves the terminal GalNAc from keratan sulfate" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004564 name: beta-fructofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985] synonym: "acid invertase activity" BROAD [] synonym: "alkaline invertase activity" BROAD [] synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] synonym: "beta-fructosidase activity" RELATED [] synonym: "beta-h-fructosidase activity" RELATED [] synonym: "fructosylinvertase activity" RELATED [] synonym: "glucosucrase activity" RELATED [] synonym: "invertase activity" BROAD [] synonym: "invertin activity" BROAD [] synonym: "maxinvert L 1000 activity" RELATED [] synonym: "saccharase activity" RELATED [] xref: EC:3.2.1.26 xref: MetaCyc:RXN-9985 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004565 name: beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "hydrolact" RELATED [EC:3.2.1.23] synonym: "lactose hydrolysis" RELATED [] synonym: "lactozym" RELATED [EC:3.2.1.23] synonym: "maxilact" RELATED [EC:3.2.1.23] synonym: "oryzatym" RELATED [EC:3.2.1.23] synonym: "S 2107" RELATED [EC:3.2.1.23] synonym: "sumiklat" RELATED [EC:3.2.1.23] synonym: "trilactase activity" EXACT [EC:3.2.1.23] xref: EC:3.2.1.23 xref: MetaCyc:3.2.1.23-RXN xref: MetaCyc:BGALACT-PWY xref: Reactome:R-HSA-1605624 "Beta-galactosidase hydrolyses GM1 to GM2" xref: Reactome:R-HSA-1606312 "Beta-galactosidase can also hydrolyse globosides to form cerebrosides" xref: Reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan" xref: Reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase" xref: Reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)" xref: Reactome:R-HSA-2265534 "Defective GLB1 does not hydrolyse a glycosaminoglycan" xref: Reactome:R-HSA-9036061 "Defective GLB1 does not hydrolyse linker chain(2)" is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004566 name: beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "ketodase activity" EXACT [EC:3.2.1.31] xref: EC:3.2.1.31 xref: MetaCyc:BETA-GLUCURONID-RXN xref: Reactome:R-HSA-1678854 "GUSB tetramer hydrolyses CS/HS precursor" xref: Reactome:R-HSA-2162226 "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc" xref: Reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2" xref: Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2" xref: Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc" xref: Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004567 name: beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannase activity" EXACT [EC:3.2.1.25] xref: EC:3.2.1.25 xref: MetaCyc:3.2.1.25-RXN xref: Reactome:R-HSA-8853710 "MANBA hydrolyses GlcNAc:Man" is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] xref: EC:3.2.1.14 xref: MetaCyc:3.2.1.14-RXN xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004569 name: glycoprotein endo-alpha-1,2-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: MetaCyc:3.2.1.130-RXN xref: Reactome:R-HSA-964759 "Alternative endo-mannosidase I route" is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0004571 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655] synonym: "1,2-alpha-mannosidase" EXACT [EC:3.2.1.113] synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] synonym: "Man9-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "man9-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "ManI activity" NARROW [EC:3.2.1.113] synonym: "mannose-9 processing alpha-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] synonym: "mannosidase I" RELATED [EC:3.2.1.113] xref: EC:3.2.1.113 xref: KEGG_REACTION:R05982 xref: KEGG_REACTION:R06722 xref: MetaCyc:3.2.1.113-RXN xref: Reactome:R-HSA-4793949 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)" xref: Reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5" xref: Reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)" xref: Reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)" xref: Reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)" xref: Reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)" xref: Reactome:R-HSA-9036008 "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)" xref: Reactome:R-HSA-9036011 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)" xref: Reactome:R-HSA-9036012 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)" xref: Reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2" xref: Reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2" xref: Reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004572 name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] synonym: "alpha-(1,3/6)-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "ManII activity" NARROW [EC:3.2.1.114] synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] synonym: "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity" EXACT [] synonym: "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity" EXACT [] synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT [] xref: EC:3.2.1.114 xref: MetaCyc:3.2.1.114-RXN xref: Reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004573 name: mannosyl-oligosaccharide glucosidase activity namespace: molecular_function def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] xref: EC:3.2.1.106 xref: MetaCyc:3.2.1.106-RXN xref: Reactome:R-HSA-4793947 "Defective MOGS does not cleave glucose from an N-glycosylated protein" xref: Reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase" is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004574 name: oligo-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10] synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] synonym: "alpha-methylglucosidase activity" RELATED [GOC:rb] synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "isomaltase activity" RELATED [EC:3.2.1.10] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] xref: EC:3.2.1.10 xref: MetaCyc:3.2.1.10-RXN is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004575 name: sucrose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461] synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD [] synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD [] synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose hydrolysis" BROAD [] synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] xref: EC:3.2.1.48 xref: KEGG_REACTION:R00802 xref: MetaCyc:RXN-1461 xref: Reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose" xref: Reactome:R-HSA-5659926 "Defective SI does not hydrolyze Suc" is_a: GO:0004564 ! beta-fructofuranosidase activity is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004576 name: oligosaccharyl transferase activity namespace: molecular_function def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] synonym: "oligosaccharide transferase activity" EXACT [GOC:mah] xref: EC:2.4.99.18 xref: RHEA:22980 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004577 name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] xref: EC:2.4.1.141 xref: MetaCyc:2.4.1.141-RXN xref: Reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP" xref: Reactome:R-HSA-5633241 "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004578 name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] xref: EC:2.4.1.142 xref: MetaCyc:2.4.1.142-RXN xref: Reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1" xref: Reactome:R-HSA-4549382 "Defective ALG1 does not transfer the first Man to the N-glycan precursor" is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0004579 name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119] xref: EC:2.4.1.119 xref: MetaCyc:2.4.1.119-RXN xref: Reactome:R-HSA-446209 "Transfer of N-glycan to the protein" is_a: GO:0004576 ! oligosaccharyl transferase activity [Term] id: GO:0004581 name: dolichyl-phosphate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] xref: EC:2.4.1.117 xref: MetaCyc:2.4.1.117-RXN xref: Reactome:R-HSA-446214 "Synthesis of dolichyl-phosphate-glucose" xref: RHEA:15401 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004582 name: dolichyl-phosphate beta-D-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "DPM synthase activity" EXACT [] synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] xref: EC:2.4.1.83 xref: MetaCyc:2.4.1.83-RXN xref: Reactome:R-HSA-162721 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose" xref: Reactome:R-HSA-4717406 "Defective DPM1 does not transfer mannose to DOLP to form DOLPman" xref: Reactome:R-HSA-4719354 "Defective DPM3 does not transfer mannose to DOLP to form DOLPman" xref: Reactome:R-HSA-4719375 "Defective DPM2 does not transfer mannose to DOLP to form DOLPman" xref: RHEA:21184 is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004583 name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah] xref: MetaCyc:RXN-5472 xref: Reactome:R-HSA-446189 "Addition of a second glucose to the N-glycan precursor by ALG8" xref: Reactome:R-HSA-446194 "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue" xref: Reactome:R-HSA-446202 "Addition of the first glucose to the N-glycan precursor by ALG6" xref: Reactome:R-HSA-4724291 "Defective ALG6 does not add glucose to the N-glycan precursor" xref: Reactome:R-HSA-4724330 "Defective ALG8 does not add glucose to the N-glycan precursor" is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0004584 name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] comment: This term represents EC 2.4.1.130 and was too unspecific and covered several different enzymes with non-overlapping catalytic activities. Consider one of the following: GO:0052925, GO:0052926, GO:0052917 or GO:0052918. GO:0004584 is scheduled for obsoletion. synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "oligomannosylsynthase activity" BROAD [EC:2.4.1.130] xref: EC:2.4.1.130 xref: MetaCyc:2.4.1.130-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004585 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: MetaCyc:RXN-13482 xref: Reactome:R-HSA-70560 "carbamoyl phosphate + ornithine => citrulline + orthophosphate" xref: RHEA:19513 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity relationship: part_of GO:0006591 ! ornithine metabolic process [Term] id: GO:0004586 name: ornithine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22964] synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] synonym: "SpeC" RELATED [EC:4.1.1.17] xref: EC:4.1.1.17 xref: KEGG_REACTION:R00670 xref: MetaCyc:ORNDECARBOX-RXN xref: Reactome:R-HSA-70692 "ornithine => putrescine + CO2" xref: RHEA:22964 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004587 name: ornithine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] synonym: "GabT" RELATED [EC:2.6.1.13] synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "OAT" RELATED [EC:2.6.1.13] synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]" xref: Reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004588 name: orotate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] synonym: "OPRT activity" EXACT [EC:2.4.2.10] synonym: "OPRTase activity" EXACT [EC:2.4.2.10] synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] xref: EC:2.4.2.10 xref: MetaCyc:OROPRIBTRANS-RXN xref: Reactome:R-HSA-73567 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate" xref: RHEA:10380 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004589 name: orotate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13513] synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] xref: EC:1.3.1.14 xref: KEGG_REACTION:R01869 xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN xref: RHEA:13513 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004590 name: orotidine-5'-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11596] synonym: "ODCase activity" EXACT [EC:4.1.1.23] synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "OMP-DC" RELATED [EC:4.1.1.23] synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] xref: EC:4.1.1.23 xref: KEGG_REACTION:R00965 xref: MetaCyc:OROTPDECARB-RXN xref: Reactome:R-HSA-73564 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2" xref: RHEA:11596 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004591 name: oxoglutarate dehydrogenase (succinyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] synonym: "AKGDH activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "OGDC activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: MetaCyc:2OXOGLUTDECARB-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004592 name: pantoate-beta-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] xref: EC:6.3.2.1 xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN xref: RHEA:10912 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004593 name: pantothenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12448] synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] xref: EC:3.5.1.22 xref: KEGG_REACTION:R02474 xref: MetaCyc:PANTOTHENASE-RXN xref: RHEA:12448 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004594 name: pantothenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] xref: EC:2.7.1.33 xref: MetaCyc:PANTOTHENATE-KIN-RXN xref: Reactome:R-HSA-196857 "PANK2 phosphorylates PanK" xref: Reactome:R-HSA-199203 "PANK1/3/4 phosphorylate PanK" xref: RHEA:16373 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004595 name: pantetheine-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19801] synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] synonym: "PPAT activity" EXACT [EC:2.7.7.3] xref: EC:2.7.7.3 xref: KEGG_REACTION:R03035 xref: MetaCyc:PANTEPADENYLYLTRAN-RXN xref: Reactome:R-HSA-196754 "COASY transfers an adenylyl group from ATP to PPANT" xref: RHEA:19801 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004596 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468] synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [] synonym: "beta-endorphin acetyltransferase activity" NARROW [] synonym: "N(alpha)-acetyltransferase activity" RELATED [] synonym: "nalpha-acetyltransferase activity" EXACT [] synonym: "NAT activity" RELATED [] synonym: "peptide acetyltransferase activity" RELATED [] synonym: "protein N-terminal acetyltransferase activity" EXACT [] xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1" is_a: GO:0034212 ! peptide N-acetyltransferase activity [Term] id: GO:0004597 name: peptide-aspartate beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] xref: EC:1.14.11.16 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004598 name: peptidylamidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] synonym: "HGAD" RELATED [EC:4.3.2.5] synonym: "PAL" RELATED [EC:4.3.2.5] synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN is_a: GO:0016842 ! amidine-lyase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004600 name: obsolete cyclophilin namespace: molecular_function def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732] comment: This term was made obsolete because it does not represent a molecular function. synonym: "cyclophilin" EXACT [] is_obsolete: true consider: GO:0003755 consider: GO:0016018 [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7, RHEA:56136] subset: goslim_metagenomics synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: KEGG_REACTION:R03532 xref: MetaCyc:PEROXID-RXN xref: MIPS_funcat:32.07.07.05 xref: Reactome:R-HSA-1222346 "AhpC reduces H2O2" xref: Reactome:R-HSA-140359 "PGG2 is reduced to PGH2 by PTGS1" xref: Reactome:R-HSA-209815 "Tyrosine is monoiodinated" xref: Reactome:R-HSA-209840 "Two DITs combine to form thyroxine" xref: Reactome:R-HSA-209925 "DIT and MIT combine to form triiodothyronine" xref: Reactome:R-HSA-209973 "Tyrosine is diiodinated" xref: Reactome:R-HSA-2309773 "PGG2 is reduced to PGH2 by PTGS2" xref: Reactome:R-HSA-2559639 "Collagen type IV sulfilimine cross-linking by peroxidasin" xref: Reactome:R-HSA-3341296 "GPX7,8 catalyze peroxidation of P4HB (PDI)" xref: Reactome:R-HSA-350901 "Iodide is organified" xref: Reactome:R-HSA-5631885 "PRDX1 overoxidizes" xref: Reactome:R-HSA-6789031 "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" xref: Reactome:R-HSA-6789126 "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" xref: Reactome:R-HSA-8855490 "Lactoperoxidase (LPO) produces OSCN-" xref: Reactome:R-HSA-8933635 "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide" xref: RHEA:56136 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0004602 name: glutathione peroxidase activity namespace: molecular_function alt_id: GO:0016224 def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: Reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4" xref: Reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4" xref: Reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4" xref: Reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4" xref: Reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: Reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: Reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: Reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: Reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O" xref: Reactome:R-HSA-71676 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: RHEA:16833 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004603 name: phenylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] xref: EC:2.1.1.28 xref: MetaCyc:2.1.1.28-RXN xref: Reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004604 name: phosphoadenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11724] synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] xref: EC:1.8.4.8 xref: KEGG_REACTION:R02021 xref: MetaCyc:1.8.4.8-RXN xref: RHEA:11724 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0004605 name: phosphatidate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "CDP-DG" RELATED [EC:2.7.7.41] synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CDP-diacylglycerol synthase activity" EXACT [] synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] synonym: "CDP-diglyceride synthase activity" EXACT [] synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] xref: EC:2.7.7.41 xref: MetaCyc:CDPDIGLYSYN-RXN xref: Reactome:R-HSA-1483121 "PA is converted to CDP-DAG by CDS1" xref: Reactome:R-HSA-1483165 "PA is converted to CDP-DAG by CDS2" xref: RHEA:16229 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004607 name: phosphatidylcholine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] synonym: "LCAT activity" EXACT [EC:2.3.1.43] synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] xref: EC:2.3.1.43 xref: MetaCyc:2.3.1.43-RXN xref: Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004608 name: phosphatidylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11164] synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] synonym: "LMTase activity" EXACT [EC:2.1.1.17] synonym: "PEMT" RELATED [EC:2.1.1.17] synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] xref: EC:2.1.1.17 xref: KEGG_REACTION:R02056 xref: MetaCyc:2.1.1.17-RXN xref: Reactome:R-HSA-1483174 "PE is methylated to PC by PEMT" xref: RHEA:11164 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004609 name: phosphatidylserine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20828] synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] xref: EC:4.1.1.65 xref: KEGG_REACTION:R02055 xref: MetaCyc:PHOSPHASERDECARB-RXN xref: Reactome:R-HSA-1483212 "PS is decarboxylated to PE by PISD" xref: RHEA:20828 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004610 name: phosphoacetylglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804] synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] xref: EC:5.4.2.3 xref: KEGG_REACTION:R08193 xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN xref: Reactome:R-HSA-446185 "Isomerization of GlcNAc6P to GlcNAc1P" xref: RHEA:23804 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004611 name: phosphoenolpyruvate carboxykinase activity namespace: molecular_function def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.32] synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "PEPCK activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004612 name: phosphoenolpyruvate carboxykinase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18617] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] synonym: "PEPK" RELATED [EC:4.1.1.49] synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] xref: EC:4.1.1.49 xref: KEGG_REACTION:R00341 xref: MetaCyc:PEPCARBOXYKIN-RXN xref: RHEA:18617 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004613 name: phosphoenolpyruvate carboxykinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 xref: MetaCyc:4.1.1.32-RXN xref: Reactome:R-HSA-372819 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]" xref: Reactome:R-HSA-70241 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]" xref: RHEA:10388 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004614 name: phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] xref: EC:5.4.2.2 xref: MetaCyc:PHOSPHOGLUCMUT-RXN xref: Reactome:R-HSA-5609939 "Defective PGM1 does not isomerise G6P to G1P" xref: Reactome:R-HSA-70272 "PGM:Mg2+ isomerise G6P to G1P" xref: Reactome:R-HSA-70427 "PGM:Mg2+ isomerise G1P to G6P" xref: Reactome:R-HSA-9638125 "PGM1:Mg2+ isomerises G1P to G6P" xref: Reactome:R-HSA-9638127 "PGM1:Mg2+ isomerises G6P to G1P" xref: RHEA:23536 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004615 name: phosphomannomutase activity namespace: molecular_function alt_id: GO:0008971 def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11140] synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] xref: EC:5.4.2.8 xref: KEGG_REACTION:R01818 xref: MetaCyc:PHOSMANMUT-RXN xref: Reactome:R-HSA-3781926 "Defective PMM2 does not isomerise Man6P to Man1P" xref: Reactome:R-HSA-446201 "PMM1,2 isomerise Man6P to Man1P" xref: RHEA:11140 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004616 name: phosphogluconate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] synonym: "6PGD activity" EXACT [EC:1.1.1.44] synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] xref: EC:1.1.1.44 xref: MetaCyc:6PGLUCONDEHYDROG-RXN xref: Reactome:R-HSA-71299 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+" xref: RHEA:10116 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004617 name: phosphoglycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "PGDH activity" EXACT [EC:1.1.1.95] synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: MetaCyc:PGLYCDEHYDROG-RXN xref: Reactome:R-HSA-977348 "3-phosphoglycerate is dehydrogenated" xref: RHEA:12641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004618 name: phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14801] synonym: "3-PGK" RELATED [EC:2.7.2.3] synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "PGK" RELATED [EC:2.7.2.3] synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] xref: EC:2.7.2.3 xref: KEGG_REACTION:R01512 xref: MetaCyc:PHOSGLYPHOS-RXN xref: Reactome:R-HSA-70486 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate" xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP" xref: RHEA:14801 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0004619 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: MetaCyc:3PGAREARR-RXN xref: Reactome:R-HSA-71445 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate" xref: Reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate" xref: RHEA:15901 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004620 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732] subset: goslim_chembl xref: EC:3.1.1 xref: Reactome:R-HSA-6786650 "DDHD1,2 hydrolyse PA" xref: Reactome:R-HSA-6792445 "LIPH, I hydrolyse PA to 2-acyl LPA" is_a: GO:0016298 ! lipase activity [Term] id: GO:0004621 name: glycosylphosphatidylinositol phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] synonym: "glycoprotein phospholipase D activity" EXACT [] synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] xref: EC:3.1.4.50 xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN xref: Reactome:R-HSA-8940388 "GPLD1 hydrolyses GPI-anchors from proteins" xref: RHEA:10832 is_a: GO:0004630 ! phospholipase D activity [Term] id: GO:0004622 name: lysophospholipase activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: goslim_chembl synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN xref: Reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: Reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: Reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: Reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: Reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: Reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: Reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho" xref: Reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho" xref: RHEA:15177 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004623 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: goslim_chembl synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN xref: Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)" xref: Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]" xref: Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A" xref: Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)" xref: Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)" xref: Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]" xref: Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A" xref: Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)" xref: Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]" xref: Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]" xref: Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]" xref: Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" xref: Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]" xref: Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]" xref: Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]" xref: Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]" xref: Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A" xref: Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]" xref: Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]" xref: Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]" xref: Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]" xref: Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1" xref: Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]" xref: Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]" xref: Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane" xref: RHEA:15801 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004624 name: obsolete secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "secreted phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0004623 consider: GO:0005576 [Term] id: GO:0004625 name: obsolete calcium-dependent secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-dependent secreted phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005576 consider: GO:0047498 [Term] id: GO:0004626 name: obsolete cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0004623 consider: GO:0005829 [Term] id: GO:0004627 name: obsolete calcium-dependent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-dependent cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005829 consider: GO:0047498 [Term] id: GO:0004628 name: obsolete calcium-independent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-independent cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005829 consider: GO:0047499 [Term] id: GO:0004629 name: phospholipase C activity namespace: molecular_function alt_id: GO:0042298 def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, GOC:mah] synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] synonym: "phosphatidase C" RELATED [EC:3.1.4.3] xref: EC:3.1.4.3 xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: Reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate" xref: Reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3" xref: Reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis" xref: Reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis" xref: Reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate" xref: Reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004630 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: goslim_chembl synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6" xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2" xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004631 name: phosphomevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16341] synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] xref: EC:2.7.4.2 xref: KEGG_REACTION:R03245 xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN xref: Reactome:R-HSA-191422 "Mevalonate-5-phosphate is further phosphorylated." xref: RHEA:16341 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0004632 name: phosphopantothenate--cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: MetaCyc:P-PANTOCYSLIG-RXN xref: Reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004633 name: phosphopantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16793] synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] xref: EC:4.1.1.36 xref: KEGG_REACTION:R03269 xref: MetaCyc:P-PANTOCYSDECARB-RXN xref: Reactome:R-HSA-196840 "3xPPCDC:3FMN decarboxylates PPC" xref: RHEA:16793 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004634 name: phosphopyruvate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732] synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] synonym: "enolase activity" EXACT [EC:4.2.1.11] synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] xref: EC:4.2.1.11 xref: MetaCyc:2PGADEHYDRAT-RXN xref: Reactome:R-HSA-70494 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate" xref: Reactome:R-HSA-71660 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O" xref: RHEA:10164 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004635 name: phosphoribosyl-AMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20049] synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] xref: EC:3.5.4.19 xref: KEGG_REACTION:R04037 xref: MetaCyc:HISTCYCLOHYD-RXN xref: RHEA:20049 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004636 name: phosphoribosyl-ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22828] synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] xref: EC:3.6.1.31 xref: KEGG_REACTION:R04035 xref: MetaCyc:HISTPRATPHYD-RXN xref: RHEA:22828 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004637 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17453] synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: KEGG_REACTION:R04144 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: Reactome:R-HSA-73814 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi" xref: RHEA:17453 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004638 name: phosphoribosylaminoimidazole carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10792] synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] synonym: "ADE2" RELATED [EC:4.1.1.21] synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] synonym: "class II PurE" RELATED [EC:4.1.1.21] xref: EC:4.1.1.21 xref: KEGG_REACTION:R04209 xref: MetaCyc:AIRCARBOXY-RXN xref: Reactome:R-HSA-73806 "AIR + CO2 => CAIR" xref: RHEA:10792 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004639 name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22628] synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "PurC" RELATED [EC:6.3.2.6] synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] synonym: "SAICARs activity" EXACT [EC:6.3.2.6] xref: EC:6.3.2.6 xref: KEGG_REACTION:R04591 xref: MetaCyc:SAICARSYN-RXN xref: Reactome:R-HSA-73805 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi" xref: RHEA:22628 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004640 name: phosphoribosylanthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21540] synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRAI activity" EXACT [EC:5.3.1.24] xref: EC:5.3.1.24 xref: KEGG_REACTION:R03509 xref: MetaCyc:PRAISOM-RXN xref: RHEA:21540 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004641 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23032] synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: KEGG_REACTION:R04208 xref: MetaCyc:AIRS-RXN xref: Reactome:R-HSA-73810 "FGAM + ATP => AIR + ADP + Pi" xref: RHEA:23032 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004642 name: phosphoribosylformylglycinamidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17129] synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "FGARAT activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] xref: EC:6.3.5.3 xref: KEGG_REACTION:R04463 xref: MetaCyc:FGAMSYN-RXN xref: Reactome:R-HSA-73812 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi" xref: RHEA:17129 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004643 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: MetaCyc:AICARTRANSFORM-RXN xref: Reactome:R-HSA-73798 "AICAR + 10-Formyl-THF => FAICAR + THF" xref: RHEA:22192 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004644 name: phosphoribosylglycinamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] synonym: "GART activity" EXACT [EC:2.1.2.2] synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] xref: EC:2.1.2.2 xref: MetaCyc:GART-RXN xref: Reactome:R-HSA-73813 "GAR + 10-Formyl-THF => FGAR + THF" xref: RHEA:15053 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004645 name: 1,4-alpha-oligoglucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] synonym: "myophosphorylase" NARROW [EC:2.4.1.1] synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] xref: EC:2.4.1.1 xref: MetaCyc:RXN-1826 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004647 name: phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: MetaCyc:PSERPHOSPHA-RXN xref: Reactome:R-HSA-977324 "phosphoserine is dephosphorylated" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004648 name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity namespace: molecular_function alt_id: GO:0004646 def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "PdxC" RELATED [EC:2.6.1.52] synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphoserine aminotransferase activity" BROAD [] synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52] synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: MetaCyc:PSERTRANSAM-RXN xref: Reactome:R-HSA-977333 "3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate" xref: RHEA:14329 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004649 name: poly(ADP-ribose) glycohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] xref: EC:3.2.1.143 xref: MetaCyc:3.2.1.143-RXN xref: Reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2" xref: Reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004650 name: polygalacturonase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] synonym: "endo-D-galacturonase activity" EXACT [] synonym: "endo-polygalacturonase activity" EXACT [] synonym: "endogalacturonase activity" EXACT [] synonym: "endopolygalacturonase activity" EXACT [] synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] synonym: "pectinase activity" NARROW [EC:3.2.1.15] synonym: "pectolase activity" EXACT [EC:3.2.1.15] synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] xref: EC:3.2.1.15 xref: MetaCyc:RXN-2103 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004651 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: Reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme" is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098507 ! polynucleotide 5' dephosphorylation [Term] id: GO:0004652 name: polynucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-72185 "mRNA polyadenylation" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004653 name: polypeptide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] xref: EC:2.4.1.41 xref: MetaCyc:2.4.1.41-RXN xref: Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins" xref: Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins" xref: Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23" xref: Reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens" is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004654 name: polyribonucleotide nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate." [EC:2.7.7.8] synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: MetaCyc:2.7.7.8-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0004655 name: porphobilinogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24064] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] synonym: "aminolevulinate dehydratase activity" EXACT [] synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] xref: EC:4.2.1.24 xref: KEGG_REACTION:R00036 xref: MetaCyc:PORPHOBILSYNTH-RXN xref: Reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG" xref: RHEA:24064 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004656 name: procollagen-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] synonym: "peptidyl proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "proline, 2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD [EC:1.14.11.2] synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] xref: EC:1.14.11.2 xref: KEGG_REACTION:R03219 xref: MetaCyc:1.14.11.2-RXN xref: Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines" is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity [Term] id: GO:0004657 name: proline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] xref: EC:1.5.99.8 xref: MetaCyc:RXN-7181 xref: Reactome:R-HSA-6784224 "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate" xref: Reactome:R-HSA-70670 "PRODH oxidises L-Pro to 1PYR-5COOH" xref: Reactome:R-HSA-8955817 "PRODH2 oxidises HPRO to 1PYR-5COOH" xref: RHEA:23784 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0004658 name: propionyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] synonym: "PCCase activity" EXACT [EC:6.4.1.3] synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] xref: EC:6.4.1.3 xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN xref: Reactome:R-HSA-71031 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate" xref: RHEA:23720 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004659 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] xref: MetaCyc:GPPSYN-RXN xref: Reactome:R-HSA-6806674 "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004660 name: protein farnesyltransferase activity namespace: molecular_function alt_id: GO:0018223 def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate. synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN xref: Reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1" is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004661 name: protein geranylgeranyltransferase activity namespace: molecular_function alt_id: GO:0018224 def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004662 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004663 name: Rab geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004664 name: prephenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] xref: EC:4.2.1.51 xref: MetaCyc:PREPHENATEDEHYDRAT-RXN xref: RHEA:21648 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004665 name: prephenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21640] synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] xref: EC:1.3.1.13 xref: KEGG_REACTION:R01730 xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21640 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004666 name: prostaglandin-endoperoxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] xref: EC:1.14.99.1 xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN xref: Reactome:R-HSA-140355 "Arachidonic acid is oxidised to PGG2 by PTGS1" xref: Reactome:R-HSA-2309787 "Arachidonic acid is oxidised to PGG2 by PTGS2" xref: RHEA:23728 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004667 name: prostaglandin-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10600] synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] xref: EC:5.3.99.2 xref: KEGG_REACTION:R02266 xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN xref: Reactome:R-HSA-2161620 "PGH2 is isomerised to PGD2 by PTGDS" xref: Reactome:R-HSA-2161701 "PGH2 is isomerised to PGD2 by HPGDS" xref: RHEA:10600 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004668 name: protein-arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] xref: EC:3.5.3.15 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN xref: Reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins" xref: Reactome:R-HSA-3247569 "PADI4 deiminates Histones" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004671 name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity namespace: molecular_function alt_id: GO:0018225 def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] xref: EC:2.1.1.100 xref: KEGG_REACTION:R04496 xref: MetaCyc:2.1.1.100-RXN xref: Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins" is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_aspergillus subset: goslim_candida synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006468 ! protein phosphorylation [Term] id: GO:0004673 name: protein histidine kinase activity namespace: molecular_function alt_id: GO:0008896 def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] synonym: "EnvZ" NARROW [EC:2.7.13.3] synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine kinase activity" EXACT [] synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] synonym: "HK1" RELATED [EC:2.7.13.3] synonym: "HP165" RELATED [EC:2.7.13.3] synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein-histidine kinase activity" EXACT [] synonym: "Sln1p" NARROW [EC:2.7.13.3] xref: EC:2.7.13.3 xref: MetaCyc:2.7.13.3-RXN is_a: GO:0004672 ! protein kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor relationship: part_of GO:0018106 ! peptidyl-histidine phosphorylation [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004695 alt_id: GO:0004696 alt_id: GO:0004700 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" xref: Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" xref: Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" xref: Reactome:R-HSA-111919 "PKA phosphorylates CREB1" xref: Reactome:R-HSA-111970 "PKC phosphorylates GRK2" xref: Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" xref: Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" xref: Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" xref: Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" xref: Reactome:R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" xref: Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" xref: Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" xref: Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" xref: Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" xref: Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" xref: Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" xref: Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" xref: Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" xref: Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" xref: Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" xref: Reactome:R-HSA-156678 "Activation of Cdc25C" xref: Reactome:R-HSA-156682 "Regulation of NUDC by phosphorylation" xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase" xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase" xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:Beclin-1 complex" xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" xref: Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" xref: Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" xref: Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" xref: Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" xref: Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" xref: Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" xref: Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" xref: Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" xref: Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" xref: Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" xref: Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" xref: Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" xref: Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" xref: Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" xref: Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" xref: Reactome:R-HSA-168140 "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex" xref: Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" xref: Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" xref: Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" xref: Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" xref: Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" xref: Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" xref: Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" xref: Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" xref: Reactome:R-HSA-176116 "Recruitment and activation of Chk1" xref: Reactome:R-HSA-176298 "Activation of claspin" xref: Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" xref: Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" xref: Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" xref: Reactome:R-HSA-193647 "IRAK is activated" xref: Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" xref: Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" xref: Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" xref: Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" xref: Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" xref: Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" xref: Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" xref: Reactome:R-HSA-198347 "AKT phosphorylates BAD" xref: Reactome:R-HSA-198371 "AKT phosphorylates GSK3" xref: Reactome:R-HSA-198599 "AKT phosphorylates MDM2" xref: Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" xref: Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" xref: Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" xref: Reactome:R-HSA-198621 "AKT phosphorylates caspase-9" xref: Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" xref: Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" xref: Reactome:R-HSA-198731 "ERK1/2 activates ELK1" xref: Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" xref: Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" xref: Reactome:R-HSA-199298 "AKT phosphorylates CREB1" xref: Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" xref: Reactome:R-HSA-199839 "AKT can phosphorylate RSK" xref: Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" xref: Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" xref: Reactome:R-HSA-199910 "MSK1 activates ATF1" xref: Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" xref: Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" xref: Reactome:R-HSA-199935 "MSK1 activates CREB" xref: Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" xref: Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" xref: Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" xref: Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" xref: Reactome:R-HSA-202222 "Phosphorylation of PKC theta" xref: Reactome:R-HSA-202437 "Phosphorylation of CARMA1" xref: Reactome:R-HSA-202459 "Phosphorylation of Bcl10" xref: Reactome:R-HSA-202500 "Activation of IKK complex" xref: Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" xref: Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" xref: Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" xref: Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" xref: Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" xref: Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" xref: Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" xref: Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" xref: Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" xref: Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" xref: Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" xref: Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" xref: Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" xref: Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" xref: Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" xref: Reactome:R-HSA-2029454 "Autophosphorylation of PAK1" xref: Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" xref: Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" xref: Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" xref: Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" xref: Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" xref: Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" xref: Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" xref: Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" xref: Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" xref: Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" xref: Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" xref: Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" xref: Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" xref: Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" xref: Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" xref: Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" xref: Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" xref: Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" xref: Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" xref: Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" xref: Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" xref: Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" xref: Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" xref: Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" xref: Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" xref: Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" xref: Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" xref: Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" xref: Reactome:R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" xref: Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" xref: Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" xref: Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" xref: Reactome:R-HSA-2730856 "Autophosphorylation of PAK" xref: Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" xref: Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" xref: Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" xref: Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" xref: Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" xref: Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" xref: Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" xref: Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" xref: Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" xref: Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" xref: Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" xref: Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" xref: Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" xref: Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" xref: Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" xref: Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" xref: Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" xref: Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" xref: Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" xref: Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" xref: Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" xref: Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" xref: Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" xref: Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" xref: Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" xref: Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" xref: Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" xref: Reactome:R-HSA-3769394 "AKT phosphorylates CBY1" xref: Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" xref: Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" xref: Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" xref: Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" xref: Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" xref: Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" xref: Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" xref: Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" xref: Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" xref: Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" xref: Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" xref: Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" xref: Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" xref: Reactome:R-HSA-3928620 "PAK1 autophosphorylates" xref: Reactome:R-HSA-3928625 "PAKs autophosphorylate" xref: Reactome:R-HSA-3928640 "PAKs phosphorylate MLC" xref: Reactome:R-HSA-399939 "Autophosphorylation of PAK" xref: Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" xref: Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" xref: Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" xref: Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" xref: Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" xref: Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" xref: Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" xref: Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" xref: Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" xref: Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" xref: Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" xref: Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" xref: Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" xref: Reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" xref: Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" xref: Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" xref: Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" xref: Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" xref: Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" xref: Reactome:R-HSA-4411402 "Activation of NLK" xref: Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" xref: Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" xref: Reactome:R-HSA-442832 "PAK phosphorylates cortactin" xref: Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" xref: Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" xref: Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" xref: Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" xref: Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" xref: Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" xref: Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" xref: Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" xref: Reactome:R-HSA-450474 "MK2 phosphorylates BRF1" xref: Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" xref: Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" xref: Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." xref: Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" xref: Reactome:R-HSA-451347 "Activation of JNK by DSCAM" xref: Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" xref: Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" xref: Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" xref: Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" xref: Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" xref: Reactome:R-HSA-5213464 "RIPK1 is phosphorylated" xref: Reactome:R-HSA-5213466 "RIPK3 is phosphorylated" xref: Reactome:R-HSA-5218814 "PAK2 autophorylates" xref: Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" xref: Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" xref: Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" xref: Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" xref: Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" xref: Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" xref: Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" xref: Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" xref: Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" xref: Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" xref: Reactome:R-HSA-5357831 "CYLD is phosphorylated by IKK" xref: Reactome:R-HSA-5578777 "DMPK phosphorylates PLN" xref: Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" xref: Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" xref: Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" xref: Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" xref: Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" xref: Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" xref: Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" xref: Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" xref: Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" xref: Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" xref: Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" xref: Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" xref: Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" xref: Reactome:R-HSA-5635841 "GLI proteins are phosphorylated" xref: Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" xref: Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" xref: Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" xref: Reactome:R-HSA-5668545 "NIK autophosphorylates on T559" xref: Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" xref: Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" xref: Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" xref: Reactome:R-HSA-5672010 "Active mTORC1 phosphorylates ULK1" xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" xref: Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" xref: Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" xref: Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" xref: Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" xref: Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" xref: Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" xref: Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" xref: Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" xref: Reactome:R-HSA-5682598 "ATM phosphorylates HERC2" xref: Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" xref: Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" xref: Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" xref: Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" xref: Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" xref: Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" xref: Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" xref: Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" xref: Reactome:R-HSA-5685156 "ATR phosphorylates RPA2" xref: Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" xref: Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" xref: Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" xref: Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" xref: Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" xref: Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" xref: Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" xref: Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" xref: Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" xref: Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" xref: Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" xref: Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" xref: Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" xref: Reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" xref: Reactome:R-HSA-5693536 "ATM phosphorylates MDC1" xref: Reactome:R-HSA-5693540 "MRN activates ATM" xref: Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" xref: Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" xref: Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" xref: Reactome:R-HSA-5693598 "ATM phosphorylates NBN" xref: Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" xref: Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" xref: Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" xref: Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" xref: Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" xref: Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" xref: Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" xref: Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" xref: Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" xref: Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" xref: Reactome:R-HSA-6799332 "ATR phosphorylates TP53" xref: Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" xref: Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" xref: Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" xref: Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" xref: Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" xref: Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" xref: Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" xref: Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" xref: Reactome:R-HSA-6804276 "ATM phosphorylates TTC5" xref: Reactome:R-HSA-6804955 "ATM phosphorylates MDM2" xref: Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" xref: Reactome:R-HSA-6805103 "AURKA phosphorylates TP53" xref: Reactome:R-HSA-6805126 "AURKB phosphorylates TP53" xref: Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" xref: Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" xref: Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" xref: Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" xref: Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20" xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" xref: Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" xref: Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" xref: Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" xref: Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" xref: Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" xref: Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" xref: Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" xref: Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" xref: Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" xref: Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" xref: Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" xref: Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" xref: Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" xref: Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" xref: Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" xref: Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" xref: Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" xref: Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" xref: Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" xref: Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" xref: Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" xref: Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" xref: Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" xref: Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" xref: Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" xref: Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" xref: Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" xref: Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" xref: Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" xref: Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" xref: Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" xref: Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" xref: Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" xref: Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" xref: Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" xref: Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" xref: Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" xref: Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" xref: Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" xref: Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" xref: Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" xref: Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" xref: Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" xref: Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" xref: Reactome:R-HSA-933525 "Phosphorylation and release of IRF7" xref: Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate" xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" xref: Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" xref: Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" xref: Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88" xref: Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" xref: Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004675 name: transmembrane receptor protein serine/threonine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30] synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "STK13" RELATED [EC:2.7.11.30] synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] xref: EC:2.7.11.30 xref: MetaCyc:2.7.11.30-RXN xref: Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly" xref: Reactome:R-HSA-198732 "STAT3 activation" xref: Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0004676 name: 3-phosphoinositide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate." [GOC:mah] synonym: "PDK activity" RELATED [PMID:10075713] synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT [] xref: Reactome:R-HSA-437195 "PDPK1 activates PRKCZ" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004677 name: DNA-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004679 name: AMP-activated protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah] synonym: "5'-AMP-activated protein kinase activity" EXACT [] synonym: "AMPK activity" RELATED [GOC:mah] synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] xref: EC:2.7.11.11 xref: Reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A" xref: Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK" xref: Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis" xref: Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2" xref: Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex" xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex" xref: Reactome:R-HSA-6805470 "AMPK phosphorylates TP53" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: has_part GO:0016208 ! AMP binding [Term] id: GO:0004680 name: obsolete casein kinase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase activity" EXACT [] xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004681 name: obsolete casein kinase I activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase I activity" EXACT [] xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004682 name: obsolete protein kinase CK2 activity namespace: molecular_function alt_id: GO:0008604 def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase II activity" RELATED [] synonym: "casein kinase II, catalytic activity" EXACT [] synonym: "protein kinase CK2 activity" EXACT [] synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004683 name: calmodulin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0004684 alt_id: GO:0004685 alt_id: GO:0004688 def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] synonym: "calmodulin regulated protein kinase activity" EXACT [] synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] synonym: "calmodulin-dependent protein kinase I activity" NARROW [] synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] synonym: "CAM PKII" RELATED [EC:2.7.11.17] synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] synonym: "CaMKI" RELATED [EC:2.7.11.17] synonym: "CaMKII" RELATED [EC:2.7.11.17] synonym: "CaMKIV" RELATED [EC:2.7.11.17] synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] synonym: "STK20" RELATED [EC:2.7.11.17] xref: EC:2.7.11.17 xref: MetaCyc:2.7.11.17-RXN xref: Reactome:R-HSA-111912 "CaMK4 phosphorylates CREB1" xref: Reactome:R-HSA-111915 "CAMK4 autophosphorylates" xref: Reactome:R-HSA-416320 "Trafficking of GluR1-containing AMPA receptors" xref: Reactome:R-HSA-442749 "CaMKK autophosphorylates in the nucleus" xref: Reactome:R-HSA-9006992 "MECP2 is phosphorylated at S423" xref: Reactome:R-HSA-9617583 "CaMKII autophosphorylates" xref: Reactome:R-HSA-9618750 "CaMKII phosphorylates AMPA receptor" xref: Reactome:R-HSA-9619125 "CaMKK phosphorylates CAMK4" xref: Reactome:R-HSA-9619355 "CaMKK autophosphorylates in the cytosol" xref: Reactome:R-HSA-9619367 "CaMKKs phosphorylate CAMK1" xref: Reactome:R-HSA-9619478 "CAMKK2 phosphorylates AMPK" xref: Reactome:R-HSA-9619783 "CAMK1 phosphorylates ARHGEF7-1" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004686 name: elongation factor-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN] synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] synonym: "eEF-2 kinase activity" EXACT [] synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eEF2K" RELATED [EC:2.7.11.20] synonym: "EF2K" RELATED [EC:2.7.11.20] synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 xref: MetaCyc:2.7.11.20-RXN is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004687 name: myosin light chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] synonym: "MLCK" RELATED [EC:2.7.11.18] synonym: "MLCkase activity" EXACT [EC:2.7.11.18] synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin-light-chain kinase activity" EXACT [] synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] synonym: "STK18" RELATED [EC:2.7.11.18] xref: EC:2.7.11.18 xref: MetaCyc:2.7.11.18-RXN xref: Reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains" xref: Reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004689 name: phosphorylase kinase activity namespace: molecular_function alt_id: GO:0008606 def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "PHK" RELATED [EC:2.7.11.19] synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] synonym: "STK17" RELATED [EC:2.7.11.19] xref: EC:2.7.11.19 xref: MetaCyc:2.7.11.19-RXN xref: Reactome:R-HSA-453337 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP" xref: Reactome:R-HSA-71541 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP" xref: Reactome:R-HSA-71588 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP" is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004690 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: has_part GO:0030551 ! cyclic nucleotide binding [Term] id: GO:0004691 name: cAMP-dependent protein kinase activity namespace: molecular_function alt_id: GO:0008602 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: MetaCyc:2.7.11.11-RXN xref: Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(666) by PKA" xref: Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA" xref: Reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit" xref: Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34" xref: Reactome:R-HSA-177284 "PKA phosphorylates PDE4B" xref: Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)" xref: Reactome:R-HSA-5610717 "PKA phosphorylates GLI2" xref: Reactome:R-HSA-5610720 "PKA phosphorylates GLI3" xref: Reactome:R-HSA-5610741 "PKA phosphorylates GLI1" xref: Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3" xref: Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN" xref: Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5" xref: Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity relationship: has_part GO:0030552 ! cAMP binding [Term] id: GO:0004692 name: cGMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "PKG" RELATED [EC:2.7.11.12] synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] synonym: "PKG 1beta" RELATED [EC:2.7.11.12] synonym: "PKG II" RELATED [EC:2.7.11.12] synonym: "STK23" RELATED [EC:2.7.11.12] xref: EC:2.7.11.12 xref: MetaCyc:2.7.11.12-RXN xref: Reactome:R-HSA-1475422 "PTPS is phosphorylated by cGMP-dependant protein kinase II" xref: Reactome:R-HSA-1497853 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II" xref: Reactome:R-HSA-418442 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release" xref: Reactome:R-HSA-418549 "PKG1 phosphorylates BK channels" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity relationship: has_part GO:0030553 ! cGMP binding [Term] id: GO:0004693 name: cyclin-dependent protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0016537 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] synonym: "CDK" RELATED [EC:2.7.11.22] synonym: "CDK activity" EXACT [] synonym: "CDK, catalytic subunit activity" EXACT [] synonym: "cdk-activating kinase activity" RELATED [EC:2.7.11.22] synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent protein kinase activity" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] xref: EC:2.7.11.22 xref: MetaCyc:2.7.11.22-RXN xref: Reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex" xref: Reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex" xref: Reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2" xref: Reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2" xref: Reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: Reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75" xref: Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21" xref: Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21" xref: Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2" xref: Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)" xref: Reactome:R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb" xref: Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8" xref: Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB" xref: Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants" xref: Reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8" xref: Reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3" xref: Reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL" xref: Reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres" xref: Reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms" xref: Reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I" xref: Reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9" xref: Reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98" xref: Reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: Reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1" xref: Reactome:R-HSA-4086410 "CDK1 phosphorylates BORA" xref: Reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1" xref: Reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN" xref: Reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments" xref: Reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6" xref: Reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218" xref: Reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes" xref: Reactome:R-HSA-6805109 "CDK2 phosphorylates TP53" xref: Reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2" xref: Reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK" xref: Reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes" xref: Reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes" xref: Reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes" xref: Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2" xref: Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0097472 ! cyclin-dependent protein kinase activity [Term] id: GO:0004694 name: eukaryotic translation initiation factor 2alpha kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0045182 ! translation regulator activity relationship: part_of GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0004697 name: protein kinase C activity namespace: molecular_function alt_id: GO:0004701 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] synonym: "cPKC" RELATED [EC:2.7.11.13] synonym: "cPKCalpha" RELATED [EC:2.7.11.13] synonym: "cPKCbeta" RELATED [EC:2.7.11.13] synonym: "cPKCgamma" RELATED [EC:2.7.11.13] synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] synonym: "nPKC" RELATED [EC:2.7.11.13] synonym: "nPKCdelta" RELATED [EC:2.7.11.13] synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] synonym: "nPKCeta" RELATED [EC:2.7.11.13] synonym: "nPKCtheta" RELATED [EC:2.7.11.13] synonym: "PKC" RELATED [EC:2.7.11.13] synonym: "PKC activity" EXACT [] synonym: "Pkc1p" RELATED [EC:2.7.11.13] synonym: "PKCalpha" RELATED [EC:2.7.11.13] synonym: "PKCbeta" RELATED [EC:2.7.11.13] synonym: "PKCdelta" RELATED [EC:2.7.11.13] synonym: "PKCepsilon" RELATED [EC:2.7.11.13] synonym: "PKCgamma" RELATED [EC:2.7.11.13] synonym: "PKCzeta" RELATED [EC:2.7.11.13] synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] synonym: "STK24" RELATED [EC:2.7.11.13] xref: EC:2.7.11.13 xref: MetaCyc:2.7.11.13-RXN xref: Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT" xref: Reactome:R-HSA-193703 "IKKbeta is activated" xref: Reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta" xref: Reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3" xref: Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta" xref: Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin" xref: Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates COL4A3BP-2" xref: Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR" xref: Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR" xref: Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC" xref: Reactome:R-HSA-5218805 "PKC autophosphorylates" xref: Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1" xref: Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation" xref: Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3" xref: Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters" xref: Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C" xref: Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP" xref: Reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)" xref: Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1" xref: Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1" xref: Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3" xref: Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727" xref: Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)" xref: Reactome:R-HSA-9626817 "PKC phosphorylates NCF1" xref: Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004698 name: calcium-dependent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-dependent PKC activity" EXACT [] synonym: "conventional protein kinase C activity" EXACT [PMID:9601053] xref: EC:2.7.11.13 xref: Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1" xref: Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4" xref: Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites" xref: Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors" is_a: GO:0004697 ! protein kinase C activity is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity [Term] id: GO:0004699 name: calcium-independent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-independent PKC activity" EXACT [] synonym: "novel protein kinase C activity" EXACT [PMID:9601053] xref: Reactome:R-HSA-5607740 "PKC-delta phosphorylates CARD9" is_a: GO:0004697 ! protein kinase C activity [Term] id: GO:0004702 name: obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein serine/threonine kinase activity" EXACT [] synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] xref: EC:2.7.11 is_obsolete: true [Term] id: GO:0004703 name: G protein-coupled receptor kinase activity namespace: molecular_function alt_id: GO:0004678 def: "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate." [GOC:dph] synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] synonym: "GPCR phosphorylating protein kinase activity" EXACT [] synonym: "GPCRK" RELATED [EC:2.7.11.16] synonym: "GRK4" RELATED [EC:2.7.11.16] synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004704 name: NF-kappaB-inducing kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151] synonym: "NIK" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling [Term] id: GO:0004705 name: JUN kinase activity namespace: molecular_function def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732] synonym: "c-Jun N-terminal kinase activity" NARROW [] synonym: "JNK" EXACT [] synonym: "JNK3alpha1" RELATED [] synonym: "SAPK1" NARROW [] xref: Reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN" xref: Reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK" xref: Reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets" xref: Reactome:R-HSA-205132 "NRAGE activates JNK" is_a: GO:0016909 ! SAP kinase activity relationship: part_of GO:0007258 ! JUN phosphorylation [Term] id: GO:0004706 name: JUN kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] synonym: "JNK kinase kinase activity" RELATED [] synonym: "JNKKK" EXACT [] is_a: GO:0004709 ! MAP kinase kinase kinase activity relationship: part_of GO:0007256 ! activation of JNKK activity [Term] id: GO:0004707 name: MAP kinase activity namespace: molecular_function alt_id: GO:0008338 alt_id: GO:0008339 alt_id: GO:0016908 def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] synonym: "Dp38" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "ERK1" EXACT [] synonym: "ERK2" RELATED [] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "LeMPK3" RELATED [EC:2.7.11.24] synonym: "MAP kinase 1 activity" NARROW [] synonym: "MAP kinase 2 activity" NARROW [] synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "MP kinase activity" NARROW [] synonym: "Mpk2" NARROW [] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p38" NARROW [] synonym: "p38-2" RELATED [EC:2.7.11.24] synonym: "p38delta" RELATED [EC:2.7.11.24] synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p42mapk" RELATED [EC:2.7.11.24] synonym: "p44mpk" RELATED [EC:2.7.11.24] synonym: "PMK-1" RELATED [EC:2.7.11.24] synonym: "PMK-2" RELATED [EC:2.7.11.24] synonym: "PMK-3" RELATED [EC:2.7.11.24] synonym: "pp42" RELATED [EC:2.7.11.24] synonym: "pp44mapk" RELATED [EC:2.7.11.24] synonym: "SAPK2" NARROW [] synonym: "STK26" RELATED [EC:2.7.11.24] xref: EC:2.7.11.24 xref: KEGG_REACTION:R00162 xref: MetaCyc:2.7.11.24-RXN xref: Reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2" xref: Reactome:R-HSA-198733 "ERK5 is activated" xref: Reactome:R-HSA-445079 "Phosphorylation of L1 by ERK" xref: Reactome:R-HSA-451366 "Activation of p38MAPK by DSCAM" xref: Reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2." xref: Reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2" xref: Reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2." xref: Reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2." xref: Reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter" xref: Reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0000165 ! MAPK cascade [Term] id: GO:0004708 name: MAP kinase kinase activity namespace: molecular_function def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] synonym: "ERK activator kinase activity" EXACT [] synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] synonym: "MAP2K" RELATED [EC:2.7.12.2] synonym: "MAPK activator activity" EXACT [GOC:vw] synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974] synonym: "MAPKK activity" EXACT [] synonym: "MAPKK1" RELATED [EC:2.7.12.2] synonym: "MEK activity" BROAD [] synonym: "MEK1" RELATED [EC:2.7.12.2] synonym: "MEK2" RELATED [EC:2.7.12.2] synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] synonym: "MKK" RELATED [EC:2.7.12.2] synonym: "MKK2" RELATED [EC:2.7.12.2] synonym: "MKK4" RELATED [EC:2.7.12.2] synonym: "MKK6" RELATED [EC:2.7.12.2] synonym: "MKK7" RELATED [EC:2.7.12.2] synonym: "STK27" RELATED [EC:2.7.12.2] xref: EC:2.7.12.2 xref: MetaCyc:2.7.12.2-RXN xref: Reactome:R-HSA-1247960 "Activation of p38 MAPK" xref: Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5" xref: Reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK" xref: Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3" xref: Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR" is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity relationship: part_of GO:0000165 ! MAPK cascade relationship: part_of GO:0000187 ! activation of MAPK activity [Term] id: GO:0004709 name: MAP kinase kinase kinase activity namespace: molecular_function alt_id: GO:0004710 def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] synonym: "cMos" RELATED [EC:2.7.11.25] synonym: "cRaf" RELATED [EC:2.7.11.25] synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974] synonym: "MAPK/ERK kinase kinase activity" EXACT [] synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] synonym: "MEKK" RELATED [EC:2.7.11.25] synonym: "MEKK activity" EXACT [] synonym: "MEKK1" RELATED [EC:2.7.11.25] synonym: "MEKK2" RELATED [EC:2.7.11.25] synonym: "MEKK3" RELATED [EC:2.7.11.25] synonym: "Mil/Raf" RELATED [EC:2.7.11.25] synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] synonym: "MLTK" RELATED [EC:2.7.11.25] synonym: "MLTKa" RELATED [EC:2.7.11.25] synonym: "MLTKb" RELATED [EC:2.7.11.25] synonym: "REKS" RELATED [EC:2.7.11.25] synonym: "STK28" RELATED [EC:2.7.11.25] xref: EC:2.7.11.25 xref: MetaCyc:2.7.11.25-RXN xref: Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex" xref: Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1" xref: Reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK" xref: Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7" xref: Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6" xref: Reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1" xref: Reactome:R-HSA-727819 "TAK1 phosphorylates MKK6" xref: Reactome:R-HSA-933530 "Activation of IKK by MEKK1" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0000165 ! MAPK cascade relationship: part_of GO:0000186 ! activation of MAPKK activity [Term] id: GO:0004711 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004712 name: protein serine/threonine/tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] synonym: "ADK1" RELATED [EC:2.7.12.1] synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] synonym: "CLK1" RELATED [EC:2.7.12.1] synonym: "dDYRK2" RELATED [EC:2.7.12.1] synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] synonym: "dual-specificity protein kinase" BROAD [] synonym: "Mps1p" RELATED [EC:2.7.12.1] synonym: "protein threonine/tyrosine kinase activity" NARROW [] xref: EC:2.7.12.1 xref: Reactome:R-HSA-5672969 "Phosphorylation of RAF" xref: Reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane" xref: Reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants" xref: Reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants" xref: Reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants" xref: Reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants" xref: Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS" xref: Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS" xref: Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated" xref: Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004713 name: protein tyrosine kinase activity namespace: molecular_function alt_id: GO:0004718 def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] synonym: "JAK" NARROW [] synonym: "Janus kinase activity" NARROW [] synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10 xref: Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1" xref: Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma" xref: Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation" xref: Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers" xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" xref: Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2" xref: Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5" xref: Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227" xref: Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4" xref: Reactome:R-HSA-1433418 "Phosphorylation of JAK2" xref: Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs" xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" xref: Reactome:R-HSA-1433506 "Phosphorylation of APS" xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs" xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" xref: Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes" xref: Reactome:R-HSA-170991 "SRC-1 autophosphorylates" xref: Reactome:R-HSA-171011 "Binding and activation of MAP Kinase" xref: Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15" xref: Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" xref: Reactome:R-HSA-177934 "EGFR autophosphorylation" xref: Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase" xref: Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)" xref: Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)" xref: Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers" xref: Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1" xref: Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1" xref: Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2" xref: Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions" xref: Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors" xref: Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3" xref: Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4" xref: Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b" xref: Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c" xref: Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b" xref: Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c" xref: Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b" xref: Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c" xref: Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c" xref: Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src" xref: Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers" xref: Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers" xref: Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2" xref: Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1" xref: Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant" xref: Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants" xref: Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant" xref: Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes" xref: Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck" xref: Reactome:R-HSA-202174 "Activation of ZAP-70" xref: Reactome:R-HSA-202216 "Phosphorylation of SLP-76" xref: Reactome:R-HSA-202233 "Inactivation of Lck by Csk" xref: Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT" xref: Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1" xref: Reactome:R-HSA-202291 "Activation of Lck" xref: Reactome:R-HSA-202307 "Change of PKC theta conformation" xref: Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers" xref: Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity" xref: Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG" xref: Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases" xref: Reactome:R-HSA-2029453 "Phosphorylation of VAV" xref: Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts" xref: Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants" xref: Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants" xref: Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity" xref: Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding" xref: Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding" xref: Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity" xref: Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants" xref: Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity" xref: Reactome:R-HSA-205289 "Autophosphorylation of KIT" xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" xref: Reactome:R-HSA-2197698 "Phosphorylation of WASP/N-WASP" xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK" xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12" xref: Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK" xref: Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK" xref: Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1" xref: Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates" xref: Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK" xref: Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK" xref: Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK" xref: Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4" xref: Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN" xref: Reactome:R-HSA-2454239 "Phosphorylation of SYK" xref: Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR" xref: Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin" xref: Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin" xref: Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin" xref: Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin" xref: Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK" xref: Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK" xref: Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK" xref: Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK" xref: Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN" xref: Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase" xref: Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta" xref: Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn" xref: Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase" xref: Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma" xref: Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F" xref: Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397" xref: Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC" xref: Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex" xref: Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN" xref: Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2" xref: Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn" xref: Reactome:R-HSA-377640 "Autophosphorylation of SRC" xref: Reactome:R-HSA-380780 "Activation of Src" xref: Reactome:R-HSA-388831 "Phosphorylation of CD28" xref: Reactome:R-HSA-388833 "Phosphorylation of CTLA-4" xref: Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors" xref: Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors" xref: Reactome:R-HSA-389354 "Activation of Vav1" xref: Reactome:R-HSA-389762 "Phosphorylation of PD-1" xref: Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha" xref: Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts" xref: Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase" xref: Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn" xref: Reactome:R-HSA-3928578 "EPH receptors autophosphorylate" xref: Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs" xref: Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B" xref: Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1" xref: Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3" xref: Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397" xref: Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1" xref: Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF" xref: Reactome:R-HSA-399934 "Phosphorylation of Plexin-A" xref: Reactome:R-HSA-399946 "Recruitment and activation of Cdk5" xref: Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes" xref: Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2" xref: Reactome:R-HSA-418163 "Activated Src activates ERK" xref: Reactome:R-HSA-418859 "Phosphorylation of Unc5C" xref: Reactome:R-HSA-418872 "Phosphorylation of FADK1" xref: Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met" xref: Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase" xref: Reactome:R-HSA-429441 "SYK activation by SRC" xref: Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation" xref: Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8" xref: Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT" xref: Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates" xref: Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1" xref: Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB" xref: Reactome:R-HSA-4420206 "Phosphorylation of SRC-1" xref: Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2" xref: Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1" xref: Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC" xref: Reactome:R-HSA-445085 "Phosphorylation of VAV2" xref: Reactome:R-HSA-445091 "Phosphorylation of Neurofascin" xref: Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1" xref: Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated" xref: Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated" xref: Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB" xref: Reactome:R-HSA-508282 "SYK is a substrate for JAK1" xref: Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2" xref: Reactome:R-HSA-5218642 "PTK2 autophosphorylates" xref: Reactome:R-HSA-5218806 "FYN autophosphorylates" xref: Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118" xref: Reactome:R-HSA-5218812 "FYN phosphorylates PAK2" xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV" xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1" xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta" xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407" xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814" xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG" xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan" xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG" xref: Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2" xref: Reactome:R-HSA-5621370 "SYK autophosphorylates" xref: Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341" xref: Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant" xref: Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII" xref: Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1" xref: Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1" xref: Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1" xref: Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1" xref: Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2" xref: Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1" xref: Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2" xref: Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2" xref: Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1" xref: Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c" xref: Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2" xref: Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3" xref: Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1" xref: Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11" xref: Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3" xref: Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11" xref: Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3" xref: Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11" xref: Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1" xref: Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3" xref: Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11" xref: Reactome:R-HSA-5655243 "Activated FGFR3 mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655270 "Activated FGFR3 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2" xref: Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1" xref: Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142" xref: Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52" xref: Reactome:R-HSA-5690702 "LYN phosphorylates CD22" xref: Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2" xref: Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2" xref: Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation" xref: Reactome:R-HSA-6806974 "MET dimers autophosphorylate" xref: Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK" xref: Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1" xref: Reactome:R-HSA-873918 "Transphosphorylation of JAK1" xref: Reactome:R-HSA-873919 "Phosphorylation of JAK2" xref: Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases" xref: Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases" xref: Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor" xref: Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2" xref: Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated" xref: Reactome:R-HSA-8847977 "FRK phosphorylates PTEN" xref: Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation" xref: Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2" xref: Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3" xref: Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B" xref: Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN" xref: Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1" xref: Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1" xref: Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1" xref: Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL" xref: Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1" xref: Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1" xref: Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2" xref: Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3" xref: Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35" xref: Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6" xref: Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ" xref: Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2" xref: Reactome:R-HSA-8851933 "MET phosphorylates GAB1" xref: Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions" xref: Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate" xref: Reactome:R-HSA-8853315 "Activated FGFR3 fusions phosphorylate FRS2" xref: Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate" xref: Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1" xref: Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB" xref: Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation" xref: Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6" xref: Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307" xref: Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15" xref: Reactome:R-HSA-8874078 "PTK2 autophosphorylates" xref: Reactome:R-HSA-8874080 "SRC phosphorylates PTK2" xref: Reactome:R-HSA-8874082 "MET phosphorylates PTK2" xref: Reactome:R-HSA-8875451 "MET phosphorylates CBL" xref: Reactome:R-HSA-8875817 "MET phosphorylates STAT3" xref: Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates" xref: Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL" xref: Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1" xref: Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1" xref: Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3" xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1" xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes" xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18" xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1" xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC" xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC" xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4" xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR" xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin" xref: Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1" xref: Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2" xref: Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3" xref: Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates" xref: Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1" xref: Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1" xref: Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1" xref: Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2" xref: Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1" xref: Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2" xref: Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2" xref: Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1" xref: Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1" xref: Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3" xref: Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates" xref: Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B" xref: Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5" xref: Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation" xref: Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate" xref: Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1" xref: Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1" xref: Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2" xref: Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer" xref: Reactome:R-HSA-909726 "Phosphorylation of STAT1" xref: Reactome:R-HSA-909729 "Activation of JAK kinases" xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2" xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" xref: Reactome:R-HSA-9606159 "BTK autophosphorylates" xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs" xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR" xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" xref: Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)" is_a: GO:0004672 ! protein kinase activity relationship: part_of GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0004714 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "sevenless receptor activity" RELATED [] xref: EC:2.7.10.1 xref: MetaCyc:2.7.10.1-RXN xref: Reactome:R-HSA-166544 "TrkA receptor autophosphorylates" xref: Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" xref: Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" xref: Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" xref: Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" xref: Reactome:R-HSA-198295 "TRKA phosphorylates IRS" xref: Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" xref: Reactome:R-HSA-74711 "Phosphorylation of IRS" xref: Reactome:R-HSA-74715 "Autophosphorylation of insulin receptor" xref: Reactome:R-HSA-74742 "Phosphorylation of SHC1" xref: Reactome:R-HSA-8852552 "MST1R autophosphorylates" xref: Reactome:R-HSA-8853792 "RET tyrosine phosphorylation" xref: Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" xref: Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" xref: Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" xref: Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" xref: Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" xref: Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" xref: Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" xref: Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" xref: Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" xref: Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" xref: Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" xref: Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" xref: Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" xref: Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" xref: Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" xref: Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" xref: Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" xref: Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" xref: Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" xref: Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" xref: Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" xref: Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" xref: Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004715 name: non-membrane spanning protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] xref: EC:2.7.10.2 xref: MetaCyc:2.7.10.2-RXN xref: Reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor" xref: Reactome:R-HSA-1112703 "PTPN11 is phosphorylated" xref: Reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2" xref: Reactome:R-HSA-1168459 "Lyn activates ERK" xref: Reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3" xref: Reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499" xref: Reactome:R-HSA-1369115 "SHP2 is phosphorylated" xref: Reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK" xref: Reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family" xref: Reactome:R-HSA-453200 "SYK autophosphorylates" xref: Reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6" xref: Reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated" xref: Reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation" xref: Reactome:R-HSA-879910 "JAK2 is phosphorylated, activated" xref: Reactome:R-HSA-8871373 "BMX phosphorylates RUFY1" is_a: GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0004716 name: obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein tyrosine kinase activity" EXACT [] synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] xref: EC:2.7.10 is_obsolete: true [Term] id: GO:0004717 name: obsolete focal adhesion kinase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. synonym: "FAK" EXACT [] synonym: "focal adhesion kinase activity" EXACT [] is_obsolete: true replaced_by: GO:0004713 [Term] id: GO:0004719 name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] xref: EC:2.1.1.77 xref: MetaCyc:2.1.1.77-RXN xref: Reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp" is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0004720 name: protein-lysine 6-oxidase activity namespace: molecular_function alt_id: GO:0018056 def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13] synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] xref: EC:1.4.3.13 xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN xref: Reactome:R-HSA-2002466 "Formation of allysine by LOX" xref: Reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase" xref: Reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004721 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: MetaCyc:3.1.3.16-RXN xref: Reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" xref: Reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin" xref: Reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A" xref: Reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A" xref: Reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" xref: Reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases" xref: Reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes" xref: Reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B" xref: Reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2" xref: Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1" xref: Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1" xref: Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I" xref: Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A" is_a: GO:0016791 ! phosphatase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006470 ! protein dephosphorylation [Term] id: GO:0004722 name: protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0000158 alt_id: GO:0000163 alt_id: GO:0008598 alt_id: GO:0008600 alt_id: GO:0015071 alt_id: GO:0030357 alt_id: GO:0030358 alt_id: GO:0030360 alt_id: GO:0030361 def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2" xref: Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate" xref: Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin" xref: Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT" xref: Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A" xref: Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34" xref: Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A" xref: Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3" xref: Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3" xref: Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1" xref: Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1" xref: Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex" xref: Reactome:R-HSA-380949 "AMPK is dephosphorylated" xref: Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1" xref: Reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate" xref: Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN" xref: Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1" xref: Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs" xref: Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1" xref: Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338" xref: Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P" xref: Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1" xref: Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2" xref: Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6" xref: Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH" xref: Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24" xref: Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2" xref: Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma" xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO" xref: Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5" xref: Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4" xref: Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII" xref: Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004723 name: calcium-dependent protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0008596 def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah] synonym: "calcineurin" NARROW [] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] xref: Reactome:R-HSA-2025882 "Calcineurin dephosphorylates NFATC1,2,3" is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004724 name: magnesium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004725 name: protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PTPase activity" EXACT [EC:3.1.3.48] synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] xref: EC:3.1.3.48 xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN xref: Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2" xref: Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR" xref: Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2" xref: Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2" xref: Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45" xref: Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)" xref: Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1" xref: Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases" xref: Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn" xref: Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)" xref: Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX" xref: Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET" xref: Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET" xref: Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation" xref: Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2" xref: Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1" xref: Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs" xref: Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6" xref: Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22" xref: Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70" xref: Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248" xref: Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)" xref: Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021" xref: Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248" xref: Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15" xref: Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1" xref: Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB" xref: Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3" xref: Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2" xref: Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B" xref: Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1" xref: Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP" is_a: GO:0004721 ! phosphoprotein phosphatase activity relationship: part_of GO:0035335 ! peptidyl-tyrosine dephosphorylation [Term] id: GO:0004726 name: non-membrane spanning protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] xref: Reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2" xref: Reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2" xref: Reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2" xref: Reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR" is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004727 name: prenylated protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004728 name: obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein tyrosine phosphatase activity" EXACT [] synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] is_obsolete: true [Term] id: GO:0004729 name: oxygen-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25576] synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] xref: EC:1.3.3.4 xref: KEGG_REACTION:R03222 xref: MetaCyc:PROTOPORGENOXI-RXN xref: Reactome:R-HSA-189423 "PPO oxidises PPGEN9 to PRIN9" xref: RHEA:25576 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity [Term] id: GO:0004730 name: pseudouridylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18337] comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine monophosphate synthase activity" EXACT [] synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine-5'-phosphate glycosidase activity" EXACT [] synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] xref: EC:4.2.1.70 xref: KEGG_REACTION:R01055 xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN xref: RHEA:18337 is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0001522 ! pseudouridine synthesis [Term] id: GO:0004731 name: purine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "PNPase activity" EXACT [EC:2.4.2.1] synonym: "PUNPI" RELATED [EC:2.4.2.1] synonym: "PUNPII" RELATED [EC:2.4.2.1] synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] xref: EC:2.4.2.1 xref: MetaCyc:PNP-RXN xref: Reactome:R-HSA-112033 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)" xref: Reactome:R-HSA-112034 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)" xref: Reactome:R-HSA-74242 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)" xref: Reactome:R-HSA-74249 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)" xref: RHEA:19805 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004732 name: pyridoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide." [EC:1.2.3.8] synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] xref: EC:1.2.3.8 xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN xref: RHEA:23724 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004733 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: MetaCyc:PMPOXI-RXN xref: Reactome:R-HSA-965019 "2xPNPO:2xFMN oxidizes PDXP to PXLP" xref: Reactome:R-HSA-965079 "2xPNPO:2xFMN oxidizes PXAP to PXLP" xref: RHEA:15817 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor relationship: part_of GO:0042823 ! pyridoxal phosphate biosynthetic process [Term] id: GO:0004734 name: pyrimidodiazepine synthase activity namespace: molecular_function def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: MetaCyc:1.5.4.1-RXN is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] id: GO:0004735 name: pyrroline-5-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] synonym: "P5CR activity" EXACT [EC:1.5.1.2] xref: EC:1.5.1.2 xref: MetaCyc:PYRROLINECARBREDUCT-RXN xref: Reactome:R-HSA-6783939 "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: Reactome:R-HSA-6783955 "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: Reactome:R-HSA-70664 "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: RHEA:14109 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004736 name: pyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20844] synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] xref: EC:6.4.1.1 xref: KEGG_REACTION:R00344 xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN xref: Reactome:R-HSA-70501 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate" xref: RHEA:20844 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0004737 name: pyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] xref: EC:4.1.1.1 xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN xref: RHEA:11628 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004738 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716720094] synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: MetaCyc:PYRUVOXID-RXN xref: MetaCyc:RXN0-1134 xref: Reactome:R-HSA-71397 "lipo-PDH decarboxylates PYR to Ac-CoA" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0004739 name: pyruvate dehydrogenase (acetyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] synonym: "PDH" RELATED [EC:1.2.4.1] synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004740 name: pyruvate dehydrogenase (acetyl-transferring) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] synonym: "PDHK" RELATED [EC:2.7.11.2] synonym: "PDK" RELATED [EC:2.7.11.2] synonym: "PDK1" RELATED [EC:2.7.11.2] synonym: "PDK2" RELATED [EC:2.7.11.2] synonym: "PDK3" RELATED [EC:2.7.11.2] synonym: "PDK4" RELATED [EC:2.7.11.2] synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: MetaCyc:2.7.11.2-RXN xref: Reactome:R-HSA-203946 "PDK isoforms phosphorylate lipo-PDH" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004741 name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity namespace: molecular_function alt_id: GO:0019906 def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: MetaCyc:3.1.3.43-RXN xref: Reactome:R-HSA-204169 "PDP dephosphorylates p-lipo-PDH" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004742 name: dihydrolipoyllysine-residue acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] xref: EC:2.3.1.12 is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004743 name: pyruvate kinase activity namespace: molecular_function def: "Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate." [EC:2.7.1.40, RHEA:18159] synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: MetaCyc:PEPDEPHOS-RXN xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens" xref: RHEA:18159 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0006096 ! glycolytic process [Term] id: GO:0004744 name: retinal isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24124] synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] xref: KEGG_REACTION:R02126 xref: MetaCyc:RETINAL-ISOMERASE-RXN xref: RHEA:24124 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0004745 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956] synonym: "retinene reductase activity" BROAD [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] xref: EC:1.1.1.105 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN xref: Reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL" xref: Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA" xref: Reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL" xref: Reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro" xref: Reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL" xref: RHEA:21284 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004746 name: riboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20772] synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] synonym: "vitamin B2 synthase activity" EXACT [] xref: EC:2.5.1.9 xref: KEGG_REACTION:R00066 xref: MetaCyc:RIBOFLAVIN-SYN-RXN xref: RHEA:20772 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004747 name: ribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] xref: EC:2.7.1.15 xref: MetaCyc:RIBOKIN-RXN xref: Reactome:R-HSA-8955844 "RBKS phosphorylates ribose to R5P" xref: RHEA:13697 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004748 name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor namespace: molecular_function alt_id: GO:0016959 alt_id: GO:0016960 alt_id: GO:0016961 def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] comment: When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] xref: EC:1.17.4.1 xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN xref: Reactome:R-HSA-111751 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" xref: Reactome:R-HSA-111804 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" xref: RHEA:23252 is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity [Term] id: GO:0004749 name: ribose phosphate diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15609] synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.1 xref: KEGG_REACTION:R01049 xref: MetaCyc:PRPPSYN-RXN xref: MetaCyc:PWY0-662 xref: Reactome:R-HSA-111215 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate" xref: Reactome:R-HSA-73580 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate" xref: RHEA:15609 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004750 name: ribulose-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13677] synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] xref: EC:5.1.3.1 xref: KEGG_REACTION:R01529 xref: MetaCyc:RIBULP3EPIM-RXN xref: Reactome:R-HSA-199803 "xylulose 5-phosphate <=> D-ribulose 5-phosphate" xref: Reactome:R-HSA-71303 "RPE dimers isomerise RU5P to XY5P" xref: RHEA:13677 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004751 name: ribose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14657] synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] xref: EC:5.3.1.6 xref: KEGG_REACTION:R01056 xref: MetaCyc:RIB5PISOM-RXN xref: Reactome:R-HSA-177784 "ribose 5-phosphate <=> D-ribulose 5-phosphate" xref: Reactome:R-HSA-5660013 "Defective RPIA does not isomerize RU5P to R5P" xref: Reactome:R-HSA-5660015 "Defective RPIA does not isomerize R5P to RU5P" xref: Reactome:R-HSA-71306 "D-ribulose 5-phosphate <=> ribose 5-phosphate" xref: RHEA:14657 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004753 name: saccharopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004754 name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12440] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] xref: EC:1.5.1.7 xref: KEGG_REACTION:R00715 xref: MetaCyc:1.5.1.7-RXN xref: RHEA:12440 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004755 name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10020] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] xref: EC:1.5.1.10 xref: KEGG_REACTION:R02315 xref: MetaCyc:RXN3O-127 xref: RHEA:10020 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004756 name: selenide, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18737] synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] synonym: "selenophosphate synthase activity" EXACT [] synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] xref: EC:2.7.9.3 xref: KEGG_REACTION:R03595 xref: MetaCyc:2.7.9.3-RXN xref: Reactome:R-HSA-8959510 "SEPHS2 phosphorylates H2Se to form SELP" xref: RHEA:18737 xref: UM-BBD_reactionID:r0833 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0004757 name: sepiapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] xref: EC:1.1.1.153 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN xref: Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)" xref: Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004758 name: serine C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14761] synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] synonym: "serine palmitoyltransferase" BROAD [] synonym: "SPT" RELATED [EC:2.3.1.50] xref: EC:2.3.1.50 xref: KEGG_REACTION:R01281 xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN xref: Reactome:R-HSA-428127 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2" xref: RHEA:14761 is_a: GO:0016454 ! C-palmitoyltransferase activity [Term] id: GO:0004760 name: serine-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0004761 alt_id: GO:0004762 alt_id: GO:0004763 def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22852] synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase activity" EXACT [] synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] synonym: "SPT" RELATED [EC:2.6.1.51] xref: EC:2.6.1.51 xref: KEGG_REACTION:R00585 xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN xref: RHEA:22852 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004764 name: shikimate 3-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25] synonym: "DHS reductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) oxidoreductase activity" BROAD [EC:1.1.1.25] xref: EC:1.1.1.25 xref: EC:1.1.1.282 xref: KEGG_REACTION:R06847 xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN xref: RHEA:17737 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004765 name: shikimate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13121] synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] xref: EC:2.7.1.71 xref: KEGG_REACTION:R02412 xref: MetaCyc:SHIKIMATE-KINASE-RXN xref: RHEA:13121 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004766 name: spermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "SpeE" RELATED [EC:2.5.1.16] synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] xref: EC:2.5.1.16 xref: MetaCyc:SPERMIDINESYN-RXN xref: Reactome:R-HSA-351215 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine" xref: RHEA:12721 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19253] subset: goslim_chembl synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: KEGG_REACTION:R02541 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: Reactome:R-HSA-1605797 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)" xref: Reactome:R-HSA-1606273 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)" xref: Reactome:R-HSA-1606288 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)" xref: Reactome:R-HSA-1640164 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin" xref: Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets" xref: RHEA:19253 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004768 name: stearoyl-CoA 9-desaturase activity namespace: molecular_function alt_id: GO:0016214 alt_id: GO:0043735 def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] comment: Note that this function was formerly EC:1.14.99.5. synonym: "acyl-CoA desaturase activity" BROAD [EC:1.14.19.1] synonym: "delta(9)-desaturase activity" BROAD [EC:1.14.19.1] synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED [] synonym: "delta9-desaturase activity" BROAD [EC:1.14.19.1] synonym: "fatty acid desaturase activity" BROAD [EC:1.14.19.1] synonym: "stearoyl-CoA desaturase activity" BROAD [] synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] xref: EC:1.14.19.1 xref: MetaCyc:1.14.19.1-RXN xref: Reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA" xref: Reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA" is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0004769 name: steroid delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "steroid D-isomerase activity" EXACT [] synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] xref: EC:5.3.3.1 xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN xref: Reactome:R-HSA-193052 "Pregn-5-ene-3,20-dione isomerizes to progesterone" xref: Reactome:R-HSA-193073 "DHA isomerizes to 4-Androstene3,17-dione" xref: Reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone" xref: Reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol" xref: Reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004771 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] subset: goslim_chembl synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters" xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004772 name: sterol O-acyltransferase activity namespace: molecular_function alt_id: GO:0017066 def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004773 name: steryl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2] synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulphatase activity" EXACT [] xref: EC:3.1.6.2 xref: MetaCyc:STERYL-SULFATASE-RXN xref: Reactome:R-HSA-1606839 "Steryl sulfatase hydrolyses sulfate from steroid sulfates" xref: RHEA:19873 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004774 name: succinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [EC:6.2.1.4, EC:6.2.1.5, GOC:ai] xref: EC:6.2.1.4 xref: RHEA:22120 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0004775 name: succinate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] synonym: "A-SCS" RELATED [EC:6.2.1.5] synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] xref: EC:6.2.1.5 xref: KEGG_REACTION:R00405 xref: MetaCyc:SUCCCOASYN-RXN xref: Reactome:R-HSA-70997 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA" xref: RHEA:17661 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004776 name: succinate-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] synonym: "G-STK" RELATED [EC:6.2.1.4] synonym: "P-enzyme" RELATED [EC:6.2.1.4] synonym: "SCS" RELATED [EC:6.2.1.4] synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] xref: EC:6.2.1.4 xref: KEGG_REACTION:R00432 xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN xref: Reactome:R-HSA-71775 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA" xref: RHEA:22120 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004777 name: succinate-semialdehyde dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0008952 def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf] synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-888548 "Conversion of succinate semialdehyde to succinate" xref: RHEA:13217 is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0004778 name: succinyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11516] synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] xref: EC:3.1.2.3 xref: KEGG_REACTION:R00407 xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN xref: RHEA:11516 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0004779 name: sulfate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] synonym: "sulphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004780 name: sulfate adenylyltransferase (ADP) activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16529] synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] xref: EC:2.7.7.5 xref: KEGG_REACTION:R00530 xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN xref: RHEA:16529 is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004781 name: sulfate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] xref: EC:2.7.7.4 xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN xref: Reactome:R-HSA-174392 "PAPSS1,2 transfer SO4(2-) group to ATP to form APS" xref: Reactome:R-HSA-3560794 "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS" xref: RHEA:18133 is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004782 name: sulfinoalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] synonym: "CSAD" RELATED [EC:4.1.1.29] synonym: "CSADCase activity" EXACT [EC:4.1.1.29] synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN xref: Reactome:R-HSA-1655443 "CSAD decarboxylates 3-sulfinoalanine to hypotaurine" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004783 name: sulfite reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [EC:1.8.1.2] synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] synonym: "sulphite reductase (NADPH) activity" EXACT [] xref: EC:1.8.1.2 xref: MetaCyc:SULFITE-REDUCT-RXN xref: RHEA:13801 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004784 name: superoxide dismutase activity namespace: molecular_function alt_id: GO:0004785 alt_id: GO:0008382 alt_id: GO:0008383 alt_id: GO:0016954 def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: MetaCyc:SUPEROX-DISMUT-RXN xref: Reactome:R-HSA-1222462 "SodB reduces superoxide to H2O2" xref: Reactome:R-HSA-1222469 "SodC reduces superoxide to H2O2" xref: Reactome:R-HSA-3299680 "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)" xref: Reactome:R-HSA-3299682 "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)" xref: Reactome:R-HSA-3299691 "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)" xref: Reactome:R-HSA-3777112 "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)" xref: RHEA:20696 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor relationship: part_of GO:0019430 ! removal of superoxide radicals [Term] id: GO:0004786 name: obsolete Mn, Fe superoxide dismutase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the function is covered by an existing term. synonym: "Mn, Fe superoxide dismutase" EXACT [] is_obsolete: true consider: GO:0004784 [Term] id: GO:0004787 name: thiamine-pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] synonym: "thiamin pyrophosphatase activity" EXACT [] synonym: "thiamin-pyrophosphatase activity" EXACT [] synonym: "thiamine pyrophosphatase activity" EXACT [] synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "TPPase activity" EXACT [] xref: EC:3.6.1 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004788 name: thiamine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2] synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin diphosphokinase activity" EXACT [] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN xref: Reactome:R-HSA-196761 "2xTPK1:Mg2+ phosphorylates THMN" xref: RHEA:11576 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004789 name: thiamine-phosphate diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22328] synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] synonym: "thiamin-phosphate diphosphorylase activity" EXACT [] synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] xref: EC:2.5.1.3 xref: KEGG_REACTION:R03223 xref: MetaCyc:THI-P-SYN-RXN xref: RHEA:22328 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004790 name: thioether S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19613] synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] xref: EC:2.1.1.96 xref: KEGG_REACTION:R02572 xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN xref: RHEA:19613 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004791 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20345] synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: KEGG_REACTION:R02016 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: Reactome:R-HSA-1222485 "TrxB reactivates TrxA" xref: Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH" xref: Reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+" xref: Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300" xref: RHEA:20345 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004792 name: thiosulfate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16881] synonym: "rhodanase activity" EXACT [EC:2.8.1.1] synonym: "rhodanese activity" RELATED [EC:2.8.1.1] synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulphate sulphurtransferase activity" EXACT [] xref: EC:2.8.1.1 xref: KEGG_REACTION:R01931 xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN xref: Reactome:R-HSA-9013198 "TST transfers sulfur from S2O3(2-) to HCN to form HSCN" xref: RHEA:16881 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004793 name: threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] synonym: "L-threonine aldolase activity" EXACT [] xref: EC:4.1.2.5 xref: MetaCyc:THREONINE-ALDOLASE-RXN xref: RHEA:19625 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004794 name: L-threonine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] comment: Note that this function was formerly EC:4.2.1.16. synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] synonym: "threonine ammonia-lyase activity" EXACT [] synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydratase activity" EXACT [] xref: EC:4.3.1.19 xref: MetaCyc:THREDEHYD-RXN xref: RHEA:22108 xref: UM-BBD_reactionID:r0433 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004795 name: threonine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] xref: EC:4.2.3.1 xref: MetaCyc:THRESYN-RXN xref: RHEA:10840 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004796 name: thromboxane-A synthase activity namespace: molecular_function alt_id: GO:0008400 def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] synonym: "cytochrome P450 CYP5" NARROW [] synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] xref: EC:5.3.99.5 xref: KEGG_REACTION:R02268 xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN xref: Reactome:R-HSA-5603275 "Defective TBXAS1 does not isomerise PGH2 to TXA2" xref: Reactome:R-HSA-76500 "TBXAS1 isomerises PGH2 to TXA2" xref: RHEA:17137 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004797 name: thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] xref: EC:2.7.1.21 xref: MetaCyc:THYKI-RXN xref: RHEA:19129 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004798 name: thymidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "dTMP kinase activity" EXACT [] synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] synonym: "TMPK activity" EXACT [EC:2.7.4.9] xref: EC:2.7.4.9 xref: MetaCyc:DTMPKI-RXN xref: RHEA:13517 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004799 name: thymidylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12104] synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] xref: EC:2.1.1.45 xref: KEGG_REACTION:R02101 xref: MetaCyc:THYMIDYLATESYN-RXN xref: Reactome:R-HSA-73605 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate" xref: RHEA:12104 is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0004800 name: thyroxine 5'-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4] comment: Note that this was EC:3.8.1.4. synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.21.99.4] synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.21.99.4] synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.21.99.4] synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.21.99.4] synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.21.99.4] synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357] synonym: "thyroxine 5' deiodinase activity" EXACT [] synonym: "thyroxine deiodinase activity" BROAD [] synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.21.99.4] synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.21.99.4] xref: EC:1.21.99.4 xref: MetaCyc:THYROXINE-DEIODINASE-RXN xref: Reactome:R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine" xref: Reactome:R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)" xref: RHEA:19745 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004801 name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2] synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2] synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2] synonym: "transaldolase activity" BROAD [EC:2.2.1.2] xref: EC:2.2.1.2 xref: MetaCyc:TRANSALDOL-RXN xref: Reactome:R-HSA-163764 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" xref: Reactome:R-HSA-5659989 "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P" xref: Reactome:R-HSA-5659998 "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P" xref: Reactome:R-HSA-71334 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" xref: RHEA:17053 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004802 name: transketolase activity namespace: molecular_function def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah] synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1] xref: EC:2.2.1.1 xref: MetaCyc:1TRANSKETO-RXN xref: Reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate" xref: Reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate" xref: Reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" xref: Reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004803 name: transposase activity namespace: molecular_function alt_id: GO:0004804 def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "P-element encoded transposase activity" NARROW [] is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0004805 name: trehalose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose phosphatase activity" EXACT [] synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] xref: EC:3.1.3.12 xref: MetaCyc:TREHALOSEPHOSPHA-RXN xref: RHEA:23420 is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004806 name: triglyceride lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] subset: goslim_chembl synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "TAG activity" EXACT [PMID:16054079] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3" xref: Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid" xref: Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA" xref: Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG" xref: Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG" xref: RHEA:12044 is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004807 name: triose-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18585] synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] xref: EC:5.3.1.1 xref: KEGG_REACTION:R01015 xref: MetaCyc:TRIOSEPISOMERIZATION-RXN xref: Reactome:R-HSA-70454 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate" xref: Reactome:R-HSA-70481 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate" xref: RHEA:18585 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004808 name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity namespace: molecular_function alt_id: GO:0016425 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] xref: EC:2.1.1.61 xref: KEGG_REACTION:R00601 xref: MetaCyc:2.1.1.61-RXN is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004809 name: tRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] xref: Reactome:R-HSA-6782416 "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)" xref: Reactome:R-HSA-6786501 "TRMT11:TRMT112 methylates guanosine-10 in tRNA" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0004810 name: tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] xref: EC:2.7.7.25 xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN is_a: GO:1990817 ! RNA adenylyltransferase activity [Term] id: GO:0004812 name: aminoacyl-tRNA ligase activity namespace: molecular_function alt_id: GO:0016876 alt_id: GO:0017100 def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [] synonym: "ligase activity, forming aminoacyl-tRNA and related compounds" BROAD [] xref: MIPS_funcat:12.10 is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004813 name: alanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine translase activity" EXACT [EC:6.1.1.7] synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-tRNA synthetase activity" EXACT [] synonym: "AlaRS" RELATED [EC:6.1.1.7] synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] xref: EC:6.1.1.7 xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379864 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" xref: Reactome:R-HSA-380177 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" xref: RHEA:12540 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004814 name: arginine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] synonym: "arginine translase activity" EXACT [EC:6.1.1.19] synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-tRNA synthetase activity" EXACT [] synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] xref: EC:6.1.1.19 xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379993 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" xref: Reactome:R-HSA-380224 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" xref: RHEA:20301 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004815 name: aspartate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-tRNA synthetase activity" EXACT [] synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] xref: EC:6.1.1.12 xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379867 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" xref: Reactome:R-HSA-380229 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" xref: RHEA:19649 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004816 name: asparagine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11180] synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-tRNA synthetase activity" EXACT [] synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] xref: EC:6.1.1.22 xref: KEGG_REACTION:R03648 xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379996 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" xref: Reactome:R-HSA-380227 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" xref: RHEA:11180 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004817 name: cysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-tRNA synthetase activity" EXACT [] synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] xref: EC:6.1.1.16 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" xref: Reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004818 name: glutamate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] xref: EC:6.1.1.17 xref: MetaCyc:GLURS-RXN xref: Reactome:R-HSA-379861 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: Reactome:R-HSA-380216 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: RHEA:23540 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004819 name: glutamine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] synonym: "GlnRS" RELATED [EC:6.1.1.18] synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] xref: EC:6.1.1.18 xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379982 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate" xref: Reactome:R-HSA-380241 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: RHEA:20121 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004820 name: glycine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.14 xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-380048 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" xref: Reactome:R-HSA-380240 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" xref: RHEA:16013 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004821 name: histidine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] synonym: "histidine translase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-tRNA synthetase activity" EXACT [] synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] xref: EC:6.1.1.21 xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379844 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" xref: Reactome:R-HSA-380234 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" xref: RHEA:17313 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004822 name: isoleucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11060] synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-tRNA synthetase activity" EXACT [] synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] xref: EC:6.1.1.5 xref: KEGG_REACTION:R03656 xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379893 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" xref: Reactome:R-HSA-380176 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" xref: RHEA:11060 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004823 name: leucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11688] synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] synonym: "leucine translase activity" EXACT [EC:6.1.1.4] synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.4 xref: KEGG_REACTION:R03657 xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" xref: Reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" xref: RHEA:11688 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004824 name: lysine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] synonym: "lysine translase activity" EXACT [EC:6.1.1.6] synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.6 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" xref: Reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004825 name: methionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] synonym: "methionine translase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-tRNA synthetase activity" EXACT [] synonym: "MetRS activity" EXACT [EC:6.1.1.10] xref: EC:6.1.1.10 xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379994 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" xref: Reactome:R-HSA-380157 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" xref: RHEA:13481 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004826 name: phenylalanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.20 xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379848 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" xref: Reactome:R-HSA-380203 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" xref: RHEA:19413 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004827 name: proline-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] synonym: "proline translase activity" EXACT [EC:6.1.1.15] synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.15 xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379865 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" xref: Reactome:R-HSA-380198 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" xref: RHEA:14305 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004828 name: serine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] synonym: "serine translase activity" EXACT [EC:6.1.1.11] synonym: "SerRS activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.11 xref: MetaCyc:SERINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379992 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" xref: Reactome:R-HSA-380239 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" xref: RHEA:12292 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004829 name: threonine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] synonym: "threonine translase activity" EXACT [EC:6.1.1.3] synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-tRNA synthetase activity" EXACT [] synonym: "TRS" RELATED [EC:6.1.1.3] xref: EC:6.1.1.3 xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-380002 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" xref: Reactome:R-HSA-380201 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" xref: RHEA:24624 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004830 name: tryptophan-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "TrpRS activity" EXACT [EC:6.1.1.2] synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.2 xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" xref: Reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" xref: RHEA:24080 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004831 name: tyrosine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10220] synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.1 xref: KEGG_REACTION:R02918 xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379980 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate" xref: Reactome:R-HSA-380170 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate" xref: RHEA:10220 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004832 name: valine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10704] synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] synonym: "valine translase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.9 xref: KEGG_REACTION:R03665 xref: MetaCyc:VALINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-380042 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" xref: Reactome:R-HSA-380199 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" xref: RHEA:10704 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004833 name: tryptophan 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0004426 def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] synonym: "TDO" RELATED [EC:1.13.11.11] synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] xref: EC:1.13.11.11 xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN xref: Reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK" xref: Reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK" xref: Reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK" xref: RHEA:24536 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004834 name: tryptophan synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10532] synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] xref: EC:4.2.1.20 xref: KEGG_REACTION:R02722 xref: MetaCyc:TRYPSYN-RXN xref: RHEA:10532 is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0000162 ! tryptophan biosynthetic process [Term] id: GO:0004835 name: tubulin-tyrosine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] synonym: "TTL activity" EXACT [EC:6.3.2.25] synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: MetaCyc:6.3.2.25-RXN xref: Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin" is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004836 name: tyramine-beta hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004837 name: tyrosine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] xref: EC:4.1.1.25 xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN xref: RHEA:14345 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004838 name: L-tyrosine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5] synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5] synonym: "TyrAT activity" RELATED [EC:2.6.1.5] synonym: "tyrosine aminotransferase activity" BROAD [] synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5] xref: EC:2.6.1.5 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-517444 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate" xref: Reactome:R-HSA-71155 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate" is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] id: GO:0004839 name: ubiquitin activating enzyme activity namespace: molecular_function def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, http://www.bostonbiochem.com/E-301.html, Wikipedia:Ubiquitin-activating_enzyme] comment: The ubiquitin activating enzyme catalyzes a ligation reaction. synonym: "E1 ubiquitin-activating enzyme" EXACT [http://enzyme.expasy.org/EC/6.2.1.45] xref: EC:6.2.1.45 xref: Reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol" xref: Reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol" xref: Reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol" xref: Reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol" xref: Reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol" xref: Reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol" is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0004842 name: ubiquitin-protein transferase activity namespace: molecular_function alt_id: GO:0004840 alt_id: GO:0004841 def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tb] synonym: "E2" RELATED [] synonym: "E3" RELATED [] synonym: "ubiquitin conjugating enzyme activity" NARROW [] synonym: "ubiquitin ligase activity" NARROW [] synonym: "ubiquitin protein ligase activity" NARROW [] synonym: "ubiquitin protein-ligase activity" NARROW [] synonym: "ubiquitin-conjugating enzyme activity" NARROW [] xref: KEGG_REACTION:R03876 xref: Reactome:R-HSA-1169394 "ISGylation of IRF3" xref: Reactome:R-HSA-1169395 "ISGylation of viral protein NS1" xref: Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase" xref: Reactome:R-HSA-1169398 "ISGylation of host protein filamin B" xref: Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes" xref: Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)" xref: Reactome:R-HSA-1169406 "ISGylation of host proteins" xref: Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha" xref: Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha" xref: Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH" xref: Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41" xref: Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3" xref: Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3" xref: Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)" xref: Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" xref: Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2" xref: Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling" xref: Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1" xref: Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP" xref: Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: Reactome:R-HSA-179417 "Multiubiquitination of Nek2A" xref: Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G" xref: Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex" xref: Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85" xref: Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)" xref: Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)" xref: Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty" xref: Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix" xref: Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty" xref: Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7" xref: Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21" xref: Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX" xref: Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand" xref: Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2" xref: Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2" xref: Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer" xref: Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1" xref: Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination" xref: Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling" xref: Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6" xref: Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6" xref: Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF" xref: Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex" xref: Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34" xref: Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7" xref: Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2" xref: Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3" xref: Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2" xref: Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7" xref: Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3" xref: Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3" xref: Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )" xref: Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels" xref: Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6" xref: Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants" xref: Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants" xref: Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants" xref: Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA" xref: Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56" xref: Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21" xref: Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1" xref: Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2" xref: Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1" xref: Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2" xref: Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)" xref: Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins" xref: Reactome:R-HSA-4332236 "CBL neddylates TGFBR2" xref: Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated" xref: Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation" xref: Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1" xref: Reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates" xref: Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1" xref: Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments" xref: Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated" xref: Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP" xref: Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex" xref: Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates" xref: Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1" xref: Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1" xref: Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2" xref: Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3" xref: Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA" xref: Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH" xref: Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA" xref: Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP" xref: Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP" xref: Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3" xref: Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK" xref: Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated" xref: Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2" xref: Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2" xref: Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains" xref: Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A" xref: Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO" xref: Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1" xref: Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4" xref: Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3" xref: Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha" xref: Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3" xref: Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex" xref: Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" xref: Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated" xref: Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS" xref: Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2" xref: Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains" xref: Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation" xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation" xref: Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane" xref: Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2" xref: Reactome:R-HSA-983153 "E1 mediated ubiquitin activation" xref: Reactome:R-HSA-983156 "Polyubiquitination of substrate" is_a: GO:0019787 ! ubiquitin-like protein transferase activity relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0004843 name: thiol-dependent ubiquitin-specific protease activity namespace: molecular_function def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709] synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746] synonym: "deubiquitinase activity" NARROW [GOC:bf] synonym: "deubiquitinating enzyme" NARROW [PMID:19188440] synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442] synonym: "ubiquitin C-terminal hydrolase activity" EXACT [EC:3.4.19.12] synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl] synonym: "ubiquitin-specific protease activity" BROAD [] synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] xref: Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8" xref: Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1" xref: Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2" xref: Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2" xref: Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling" xref: Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA" xref: Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA" xref: Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1" xref: Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6" xref: Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48" xref: Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN" xref: Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN" xref: Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin" xref: Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin" xref: Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin" xref: Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin" xref: Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1" xref: Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1" is_a: GO:0036459 ! thiol-dependent ubiquitinyl hydrolase activity [Term] id: GO:0004844 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623] synonym: "uracil-DNA glycosylase activity" EXACT [] xref: Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase" xref: Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase" is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity [Term] id: GO:0004845 name: uracil phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13017] synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UPRTase activity" EXACT [EC:2.4.2.9] synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] xref: EC:2.4.2.9 xref: KEGG_REACTION:R00966 xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN xref: RHEA:13017 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004846 name: urate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3] synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] synonym: "uricase activity" EXACT [EC:1.7.3.3] synonym: "uricase II activity" NARROW [EC:1.7.3.3] xref: EC:1.7.3.3 xref: MetaCyc:URATE-OXIDASE-RXN xref: RHEA:21368 xref: UM-BBD_reactionID:r1322 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0004847 name: urea carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20896] synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "UALase activity" EXACT [EC:6.3.4.6] synonym: "UCA activity" EXACT [EC:6.3.4.6] synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] xref: EC:6.3.4.6 xref: KEGG_REACTION:R00774 xref: MetaCyc:UREA-CARBOXYLASE-RXN xref: RHEA:20896 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004848 name: ureidoglycolate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.1.116, RHEA:19809] comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [] xref: EC:3.5.3.19 xref: KEGG_REACTION:R00469 xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN xref: RHEA:19809 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004849 name: uridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] synonym: "uridine kinase reaction" EXACT [] synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] xref: EC:2.7.1.48 xref: MetaCyc:URIDINEKIN-RXN xref: Reactome:R-HSA-8954327 "UCKL1 phosphorylates urindine, cytidine" xref: RHEA:16825 is_a: GO:0019206 ! nucleoside kinase activity relationship: part_of GO:0006222 ! UMP biosynthetic process [Term] id: GO:0004850 name: uridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] synonym: "UPase activity" EXACT [EC:2.4.2.3] synonym: "UPH" RELATED [EC:2.4.2.3] synonym: "UrdPase activity" EXACT [EC:2.4.2.3] synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] xref: EC:2.4.2.3 xref: MetaCyc:URPHOS-RXN xref: Reactome:R-HSA-74372 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]" xref: Reactome:R-HSA-74376 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)" xref: RHEA:24388 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004851 name: uroporphyrin-III C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "CobA" RELATED [EC:2.1.1.107] synonym: "CysG" RELATED [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "SirA" RELATED [EC:2.1.1.107] synonym: "SUMT activity" EXACT [EC:2.1.1.107] synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004852 name: uroporphyrinogen-III synthase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18965] synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] xref: EC:4.2.1.75 xref: KEGG_REACTION:R03165 xref: MetaCyc:UROGENIIISYN-RXN xref: Reactome:R-HSA-189488 "UROS transforms HMB to URO3" xref: RHEA:18965 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004853 name: uroporphyrinogen decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] xref: EC:4.1.1.37 xref: MetaCyc:UROGENDECARBOX-RXN xref: Reactome:R-HSA-189425 "UROD decarboxylates URO3 to COPRO3" xref: Reactome:R-HSA-190182 "UROD decarboxylates URO1 to COPRO1" xref: RHEA:19865 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004854 name: xanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: MetaCyc:RXN0-901 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0004855 name: xanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2] synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] xref: EC:1.17.3.2 xref: MetaCyc:XANTHINE-OXIDASE-RXN xref: Reactome:R-HSA-74247 "Hypoxanthine + H2O + O2 => Xanthine + H2O2" xref: Reactome:R-HSA-74258 "Xanthine + H2O + O2 => Urate + H2O2" xref: RHEA:21132 xref: UM-BBD_enzymeID:e0781 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0004856 name: xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10964] synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] xref: EC:2.7.1.17 xref: KEGG_REACTION:R01639 xref: MetaCyc:XYLULOKIN-RXN xref: Reactome:R-HSA-5662466 "XYLB phosphorylates D-xylulose" xref: RHEA:10964 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004857 name: enzyme inhibitor activity namespace: molecular_function alt_id: GO:0048551 def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] synonym: "metalloenzyme inhibitor activity" NARROW [] xref: MIPS_funcat:18.02.01.02 is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0043086 ! negative regulation of catalytic activity [Term] id: GO:0004858 name: dUTP pyrophosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004170 ! dUTP diphosphatase activity [Term] id: GO:0004859 name: phospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] is_a: GO:0055102 ! lipase inhibitor activity relationship: negatively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0004860 name: protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019210 ! kinase inhibitor activity is_a: GO:0019887 ! protein kinase regulator activity relationship: negatively_regulates GO:0004672 ! protein kinase activity relationship: part_of GO:0006469 ! negative regulation of protein kinase activity [Term] id: GO:0004861 name: cyclin-dependent protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD [] xref: Reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21" is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity relationship: part_of GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0004862 name: cAMP-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] xref: Reactome:R-HSA-180073 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function" is_a: GO:0008603 ! cAMP-dependent protein kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity relationship: part_of GO:2000480 ! negative regulation of cAMP-dependent protein kinase activity [Term] id: GO:0004864 name: protein phosphatase inhibitor activity namespace: molecular_function alt_id: GO:1990681 def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai] synonym: "phosphoprotein phosphatase inhibitor activity" EXACT [] synonym: "protein phosphatase 2 inhibitor activity" NARROW [GOC:dph] synonym: "protein phosphatase type 2A inhibitor activity" NARROW [] is_a: GO:0019212 ! phosphatase inhibitor activity is_a: GO:0019888 ! protein phosphatase regulator activity relationship: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity relationship: part_of GO:0032515 ! negative regulation of phosphoprotein phosphatase activity created_by: rb creation_date: 2015-03-03T23:57:25Z [Term] id: GO:0004865 name: protein serine/threonine phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb] is_a: GO:0004864 ! protein phosphatase inhibitor activity [Term] id: GO:0004866 name: endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] synonym: "alpha-2 macroglobulin" RELATED [] synonym: "endoproteinase inhibitor" NARROW [] synonym: "proteinase inhibitor" NARROW [] is_a: GO:0030414 ! peptidase inhibitor activity is_a: GO:0061135 ! endopeptidase regulator activity relationship: negatively_regulates GO:0004175 ! endopeptidase activity relationship: part_of GO:0010951 ! negative regulation of endopeptidase activity [Term] id: GO:0004867 name: serine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] synonym: "serine protease inhibitor activity" NARROW [] synonym: "serine proteinase inhibitor activity" NARROW [] synonym: "serpin activity" NARROW [] xref: Reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1" xref: Reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1" xref: Reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin" xref: Reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR" xref: Reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR" is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0004252 ! serine-type endopeptidase activity [Term] id: GO:0004868 name: obsolete serpin namespace: molecular_function def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "serpin" EXACT [] is_obsolete: true consider: GO:0004867 [Term] id: GO:0004869 name: cysteine-type endopeptidase inhibitor activity namespace: molecular_function alt_id: GO:0004870 def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] synonym: "cystatin" NARROW [GOC:jl] synonym: "cysteine protease inhibitor activity" NARROW [GOC:dph, GOC:tb] synonym: "thiol protease inhibitor" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004871 name: obsolete signal transducer activity namespace: molecular_function alt_id: GO:0005062 alt_id: GO:0009369 alt_id: GO:0009370 def: "OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] comment: This term was obsoleted because it was not clearly defined and is not a useful grouping term, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW [] synonym: "quorum sensing response regulator activity" NARROW [] synonym: "quorum sensing signal generator activity" NARROW [] is_obsolete: true [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein] subset: goslim_chembl is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0004874 name: obsolete aryl hydrocarbon receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, PMID:1325649, PMID:7493958, Wikipedia:Aryl_hydrocarbon_receptor] comment: This term was obsoleted because it represents a gene product, see https://github.com/geneontology/go-ontology/issues/16732 is_obsolete: true [Term] id: GO:0004875 name: complement receptor activity namespace: molecular_function alt_id: GO:0004942 def: "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. synonym: "anaphylatoxin receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0001848 ! complement binding relationship: part_of GO:0002430 ! complement receptor mediated signaling pathway [Term] id: GO:0004876 name: complement component C3a receptor activity namespace: molecular_function alt_id: GO:0004943 def: "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] synonym: "C3a anaphylatoxin receptor activity" RELATED [] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004877 name: complement component C3b receptor activity namespace: molecular_function def: "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001850 ! complement component C3a binding relationship: has_part GO:0001851 ! complement component C3b binding [Term] id: GO:0004878 name: complement component C5a receptor activity namespace: molecular_function alt_id: GO:0004944 def: "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] synonym: "C5a anaphylatoxin receptor activity" RELATED [] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity relationship: has_part GO:0001856 ! complement component C5a binding relationship: part_of GO:0038178 ! complement component C5a signaling pathway [Term] id: GO:0004879 name: nuclear receptor activity namespace: molecular_function alt_id: GO:0003708 alt_id: GO:0004880 alt_id: GO:0004882 alt_id: GO:0004884 alt_id: GO:0004886 alt_id: GO:0004887 alt_id: GO:0008434 alt_id: GO:0038050 alt_id: GO:0038051 alt_id: GO:0038052 def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'nuclear receptor transcription coactivator activity ; GO:0030374'. synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol] synonym: "9-cis retinoic acid receptor activity" NARROW [] synonym: "androgen receptor activity" NARROW [] synonym: "calcitriol receptor activity" NARROW [] synonym: "ecdysteroid hormone receptor activity" NARROW [] synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf] synonym: "glucocorticoid receptor activity" NARROW [GOC:bf] synonym: "juvenile hormone receptor activity" NARROW [] synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf] synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf] synonym: "nuclear hormone receptor" NARROW [] synonym: "nuclear receptor activity" RELATED [GOC:bf] synonym: "retinoic acid receptor activity" NARROW [] synonym: "retinoid-X receptor activity" NARROW [GOC:bf] synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT [] synonym: "RXR" NARROW [] synonym: "thyroid hormone receptor activity" NARROW [] synonym: "vitamin A receptor activity" NARROW [] synonym: "vitamin D receptor activity" NARROW [] synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific is_a: GO:0098531 ! ligand-activated transcription factor activity relationship: part_of GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0004883 name: glucocorticoid receptor activity namespace: molecular_function def: "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967] comment: If the mechanism by which a glucocorticoid receptor functions is known, consider instead annotating to the child terms 'glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038050' or 'glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038051'. is_a: GO:0003707 ! steroid hormone receptor activity relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway relationship: part_of GO:0043402 ! glucocorticoid mediated signaling pathway [Term] id: GO:0004888 name: transmembrane signaling receptor activity namespace: molecular_function alt_id: GO:0004926 alt_id: GO:0099600 def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0004890 name: GABA-A receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. synonym: "ionotropic GABA receptor activity" EXACT [GOC:bf] is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004892 name: obsolete B cell receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "B cell receptor activity" EXACT [] is_obsolete: true consider: GO:0003823 [Term] id: GO:0004894 name: obsolete T cell receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. synonym: "T cell receptor activity" EXACT [] is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0004895 name: cell adhesion receptor activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins." [GOC:BHF-UCL, Wikipedia:Cell_adhesion] comment: Reinstated term, see https://github.com/geneontology/go-ontology/issues/15237 is_a: GO:0038023 ! signaling receptor activity is_a: GO:0098631 ! cell adhesion mediator activity [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function alt_id: GO:0004907 def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0019955 ! cytokine binding relationship: part_of GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0004897 name: ciliary neurotrophic factor receptor activity namespace: molecular_function def: "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CNTF receptor activity" EXACT [GOC:mah] synonym: "gp130" RELATED [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0070119 ! ciliary neurotrophic factor binding relationship: part_of GO:0070120 ! ciliary neurotrophic factor-mediated signaling pathway [Term] id: GO:0004898 name: obsolete gp130 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product. synonym: "gp130" EXACT [] is_obsolete: true consider: GO:0004897 consider: GO:0004915 consider: GO:0004921 [Term] id: GO:0004900 name: erythropoietin receptor activity namespace: molecular_function def: "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0038162 ! erythropoietin-mediated signaling pathway [Term] id: GO:0004901 name: granulocyte macrophage colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030525 def: "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CSF-2 receptor activity" EXACT [GOC:bf] synonym: "CSF2R" RELATED [GOC:bf] synonym: "GM-CSF receptor activity" EXACT [] synonym: "GMC-SF receptor activity" EXACT [] synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042021 ! granulocyte macrophage colony-stimulating factor complex binding relationship: part_of GO:0038157 ! granulocyte-macrophage colony-stimulating factor signaling pathway [Term] id: GO:0004902 name: granulocyte colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030524 def: "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CSF3R" RELATED [GOC:bf] synonym: "G-CSF receptor activity" EXACT [GOC:bf] synonym: "granulocyte colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0051916 ! granulocyte colony-stimulating factor binding relationship: part_of GO:0038158 ! granulocyte colony-stimulating factor signaling pathway [Term] id: GO:0004903 name: growth hormone receptor activity namespace: molecular_function def: "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004904 name: interferon receptor activity namespace: molecular_function def: "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096] synonym: "IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019961 ! interferon binding [Term] id: GO:0004905 name: type I interferon receptor activity namespace: molecular_function def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] synonym: "interferon-delta receptor activity" NARROW [] synonym: "interferon-epsilon receptor activity" NARROW [] synonym: "interferon-kappa receptor activity" NARROW [] synonym: "interferon-omega receptor activity" NARROW [] synonym: "interferon-tau receptor activity" NARROW [] synonym: "interferon-zeta receptor activity" NARROW [] synonym: "type I IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004904 ! interferon receptor activity relationship: has_part GO:0019962 ! type I interferon binding relationship: part_of GO:0060337 ! type I interferon signaling pathway [Term] id: GO:0004906 name: interferon-gamma receptor activity namespace: molecular_function def: "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383] synonym: "IFN-gamma receptor activity" EXACT [GOC:mah] synonym: "IFNG receptor activity" EXACT [GOC:mah] synonym: "type II interferon receptor activity" BROAD [] is_a: GO:0004904 ! interferon receptor activity relationship: has_part GO:0019964 ! interferon-gamma binding relationship: part_of GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0004908 name: interleukin-1 receptor activity namespace: molecular_function def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] synonym: "IL-1 receptor activity" EXACT [] synonym: "IL-1R" EXACT [] xref: Wikipedia:Interleukin-1_receptor is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019966 ! interleukin-1 binding [Term] id: GO:0004909 name: interleukin-1, type I, activating receptor activity namespace: molecular_function alt_id: GO:0019967 def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828] synonym: "IL-1 type I, activating binding" EXACT [] synonym: "IL-1 type I, activating receptor" EXACT [] synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 type I receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, type I, activating binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity relationship: part_of GO:0070498 ! interleukin-1-mediated signaling pathway [Term] id: GO:0004910 name: interleukin-1, type II, blocking receptor activity namespace: molecular_function alt_id: GO:0019968 def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828] synonym: "IL-1 type II, blocking binding" EXACT [] synonym: "IL-1 type II, blocking receptor" EXACT [] synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 type II receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, type II, blocking binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004911 name: interleukin-2 receptor activity namespace: molecular_function def: "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-2 receptor activity" EXACT [GOC:mah] synonym: "IL-2R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019976 ! interleukin-2 binding relationship: part_of GO:0038110 ! interleukin-2-mediated signaling pathway [Term] id: GO:0004912 name: interleukin-3 receptor activity namespace: molecular_function def: "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-3 receptor activity" EXACT [GOC:mah] synonym: "IL-3R" EXACT [] xref: Wikipedia:Interleukin-3_receptor is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019978 ! interleukin-3 binding relationship: part_of GO:0036016 ! cellular response to interleukin-3 relationship: part_of GO:0038156 ! interleukin-3-mediated signaling pathway [Term] id: GO:0004913 name: interleukin-4 receptor activity namespace: molecular_function def: "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-4 receptor activity" EXACT [GOC:mah] synonym: "IL-4R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019979 ! interleukin-4 binding relationship: part_of GO:0035771 ! interleukin-4-mediated signaling pathway [Term] id: GO:0004914 name: interleukin-5 receptor activity namespace: molecular_function def: "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-5 receptor activity" EXACT [GOC:mah] synonym: "IL-5R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019980 ! interleukin-5 binding relationship: part_of GO:0038043 ! interleukin-5-mediated signaling pathway [Term] id: GO:0004915 name: interleukin-6 receptor activity namespace: molecular_function def: "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "gp130" RELATED [] synonym: "IL-6 receptor activity" EXACT [GOC:mah] synonym: "IL-6R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019981 ! interleukin-6 binding relationship: part_of GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0004917 name: interleukin-7 receptor activity namespace: molecular_function def: "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-7 receptor activity" EXACT [GOC:mah] synonym: "IL-7R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019982 ! interleukin-7 binding relationship: part_of GO:0038111 ! interleukin-7-mediated signaling pathway [Term] id: GO:0004918 name: interleukin-8 receptor activity namespace: molecular_function def: "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-8 receptor activity" EXACT [GOC:mah] synonym: "IL-8R" EXACT [] is_a: GO:0016494 ! C-X-C chemokine receptor activity relationship: has_part GO:0019959 ! interleukin-8 binding relationship: part_of GO:0038112 ! interleukin-8-mediated signaling pathway [Term] id: GO:0004919 name: interleukin-9 receptor activity namespace: molecular_function def: "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-9 receptor activity" EXACT [GOC:mah] synonym: "IL-9R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019983 ! interleukin-9 binding relationship: part_of GO:0038113 ! interleukin-9-mediated signaling pathway [Term] id: GO:0004920 name: interleukin-10 receptor activity namespace: molecular_function def: "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-10 receptor activity" EXACT [GOC:mah] synonym: "IL-10R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019969 ! interleukin-10 binding [Term] id: GO:0004921 name: interleukin-11 receptor activity namespace: molecular_function def: "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "gp130" RELATED [] synonym: "IL-11 receptor activity" EXACT [GOC:mah] synonym: "IL-11R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019970 ! interleukin-11 binding relationship: part_of GO:0038154 ! interleukin-11-mediated signaling pathway [Term] id: GO:0004923 name: leukemia inhibitory factor receptor activity namespace: molecular_function alt_id: GO:0004899 def: "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling] synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah] synonym: "LIF receptor activity" EXACT [GOC:mah] is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity relationship: part_of GO:0048861 ! leukemia inhibitory factor signaling pathway [Term] id: GO:0004924 name: oncostatin-M receptor activity namespace: molecular_function def: "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0038165 ! oncostatin-M-mediated signaling pathway [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0038161 ! prolactin signaling pathway [Term] id: GO:0004927 name: obsolete sevenless receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "sevenless receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0004888 consider: GO:0008288 [Term] id: GO:0004928 name: obsolete frizzled receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "frizzled receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0042813 consider: GO:0016055 [Term] id: GO:0004929 name: obsolete frizzled-2 receptor activity namespace: molecular_function def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "frizzled-2 receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0042813 consider: GO:0007223 [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:R-HSA-114552 "G12/13 activation by PAR" xref: Reactome:R-HSA-114558 "Gq activation by PAR" xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Wikipedia:GPCR is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0004931 name: extracellularly ATP-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:bf, GOC:mah, PMID:9755289] comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. synonym: "P2X receptor" RELATED [PMID:9755289] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] xref: Reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+" is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0035381 ! ATP-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004932 name: mating-type factor pheromone receptor activity namespace: molecular_function def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw] is_a: GO:0008528 ! G protein-coupled peptide receptor activity is_a: GO:0016503 ! pheromone receptor activity [Term] id: GO:0004933 name: mating-type a-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity [Term] id: GO:0004934 name: mating-type alpha-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity [Term] id: GO:0004935 name: adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] synonym: "adrenoceptor activity" EXACT [] xref: Wikipedia:Adrenergic_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity relationship: part_of GO:0071875 ! adrenergic receptor signaling pathway [Term] id: GO:0004936 name: alpha-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004937 name: alpha1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha1 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004938 name: alpha2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha2 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004939 name: beta-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "beta adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004940 name: beta1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta1 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004941 name: beta2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta2 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004945 name: angiotensin type II receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0004946 name: bombesin receptor activity namespace: molecular_function def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity relationship: part_of GO:0031989 ! bombesin receptor signaling pathway [Term] id: GO:0004947 name: bradykinin receptor activity namespace: molecular_function def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004948 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645] is_a: GO:0097642 ! calcitonin family receptor activity relationship: has_part GO:0032841 ! calcitonin binding [Term] id: GO:0004949 name: cannabinoid receptor activity namespace: molecular_function def: "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid] synonym: "cannaboid receptor" EXACT [] synonym: "endocannabinoid receptor activity" NARROW [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: part_of GO:0038171 ! cannabinoid signaling pathway [Term] id: GO:0004950 name: chemokine receptor activity namespace: molecular_function def: "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] is_a: GO:0001637 ! G protein-coupled chemoattractant receptor activity is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019956 ! chemokine binding relationship: part_of GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0004951 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394] synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0038188 ! cholecystokinin signaling pathway [Term] id: GO:0004952 name: dopamine neurotransmitter receptor activity namespace: molecular_function def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983] is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity relationship: has_part GO:0035240 ! dopamine binding relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic relationship: part_of GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0004953 name: icosanoid receptor activity namespace: molecular_function def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] synonym: "eicosanoid receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: has_part GO:0050542 ! icosanoid binding [Term] id: GO:0004954 name: prostanoid receptor activity namespace: molecular_function def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732] is_a: GO:0004953 ! icosanoid receptor activity [Term] id: GO:0004955 name: prostaglandin receptor activity namespace: molecular_function def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004956 name: prostaglandin D receptor activity namespace: molecular_function def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGD receptor activity" RELATED [] synonym: "PGD(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004957 name: prostaglandin E receptor activity namespace: molecular_function def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGE receptor activity" RELATED [] synonym: "PGE(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004958 name: prostaglandin F receptor activity namespace: molecular_function def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGF receptor activity" RELATED [] synonym: "PGF(2-alpha) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004960 name: thromboxane receptor activity namespace: molecular_function def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732] synonym: "TXA receptor activity" EXACT [] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004961 name: thromboxane A2 receptor activity namespace: molecular_function def: "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732] synonym: "TXA(2) receptor activity" EXACT [] synonym: "TXA2 receptor activity" EXACT [PMID:15242977] is_a: GO:0004960 ! thromboxane receptor activity relationship: part_of GO:0038193 ! thromboxane A2 signaling pathway [Term] id: GO:0004962 name: endothelin receptor activity namespace: molecular_function alt_id: GO:0001599 alt_id: GO:0001600 def: "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265] synonym: "endothelin-A receptor activity" NARROW [GOC:bf, PMID:8582288] synonym: "endothelin-B receptor activity" NARROW [GOC:bf, PMID:8582288] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0086100 ! endothelin receptor signaling pathway [Term] id: GO:0004963 name: follicle-stimulating hormone receptor activity namespace: molecular_function def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "follicle stimulating hormone receptor activity" EXACT [] synonym: "FSH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity relationship: part_of GO:0042699 ! follicle-stimulating hormone signaling pathway [Term] id: GO:0004964 name: luteinizing hormone receptor activity namespace: molecular_function alt_id: GO:0004976 def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095] synonym: "LH receptor" EXACT [PMID:18848524] synonym: "LHR" EXACT [PMID:18848524] synonym: "lutropin receptor" EXACT [ISBN:0198506732] synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity relationship: part_of GO:0042700 ! luteinizing hormone signaling pathway [Term] id: GO:0004965 name: G protein-coupled GABA receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] synonym: "G-protein coupled GABA receptor activity" EXACT [] synonym: "GABA-B receptor activity" RELATED [GOC:bf] synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor] xref: Reactome:R-HSA-1013012 "Binding of Gbeta/gamma to GIRK/Kir3 channels" xref: Reactome:R-HSA-1013013 "Association of GABA B receptor with G protein beta-gamma subunits" is_a: GO:0016917 ! GABA receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004966 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004967 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0071377 ! cellular response to glucagon stimulus [Term] id: GO:0004968 name: gonadotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah] synonym: "GnRH receptor activity" EXACT [] synonym: "gonadotrophin-releasing hormone receptor activity" EXACT [GOC:dph] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity relationship: has_part GO:0051448 ! gonadotropin-releasing hormone binding relationship: part_of GO:0097211 ! cellular response to gonadotropin-releasing hormone [Term] id: GO:0004969 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity relationship: has_part GO:0051381 ! histamine binding [Term] id: GO:0004970 name: ionotropic glutamate receptor activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. is_a: GO:0008066 ! glutamate receptor activity is_a: GO:0022824 ! transmitter-gated ion channel activity relationship: part_of GO:0035235 ! ionotropic glutamate receptor signaling pathway [Term] id: GO:0004971 name: AMPA glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT [] synonym: "AMPA receptor activity" EXACT [] is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004972 name: NMDA glutamate receptor activity namespace: molecular_function def: "An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages." [GOC:mah, PMID:10049997] comment: The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product. synonym: "N-methyl-D-aspartate selective glutamate receptor activity" EXACT [] synonym: "NMDA receptor" EXACT [] xref: Wikipedia:NMDA_receptor is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0022843 ! voltage-gated cation channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004973 name: obsolete N-methyl-D-aspartate receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "N-methyl-D-aspartate receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0004974 name: leukotriene receptor activity namespace: molecular_function def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] is_a: GO:0004953 ! icosanoid receptor activity relationship: part_of GO:0061737 ! leukotriene signaling pathway [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004978 name: corticotropin receptor activity namespace: molecular_function def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] synonym: "adrenocorticotropin receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity relationship: has_part GO:0042562 ! hormone binding [Term] id: GO:0004979 name: beta-endorphin receptor activity namespace: molecular_function def: "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin] synonym: "mu-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0004985 ! opioid receptor activity is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity relationship: has_part GO:0031626 ! beta-endorphin binding [Term] id: GO:0004980 name: melanocyte-stimulating hormone receptor activity namespace: molecular_function def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459] synonym: "melanocyte stimulating hormone receptor activity" EXACT [] synonym: "melanophore-stimulating hormone receptor activity" EXACT [] synonym: "MSH receptor activity" BROAD [] synonym: "MSHR activity" BROAD [] is_a: GO:0004977 ! melanocortin receptor activity relationship: has_part GO:0042562 ! hormone binding [Term] id: GO:0004982 name: N-formyl peptide receptor activity namespace: molecular_function def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] synonym: "Fmet-leu-phe receptor" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004983 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004984 name: olfactory receptor activity namespace: molecular_function def: "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell [Term] id: GO:0004985 name: opioid receptor activity namespace: molecular_function def: "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:20494127] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:0004986 name: obsolete delta-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "delta-opioid receptor activity" EXACT [] xref: Wikipedia:Delta_Opioid_receptor is_obsolete: true consider: GO:0038046 [Term] id: GO:0004987 name: obsolete kappa-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "kappa-opioid receptor activity" EXACT [] xref: Wikipedia:Kappa_Opioid_receptor is_obsolete: true consider: GO:0038048 [Term] id: GO:0004988 name: obsolete mu-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "mu-opioid receptor activity" EXACT [] xref: Wikipedia:Mu_Opioid_receptor is_obsolete: true consider: GO:0004979 consider: GO:0038046 consider: GO:0038047 [Term] id: GO:0004989 name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004990 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004991 name: parathyroid hormone receptor activity namespace: molecular_function def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004992 name: platelet activating factor receptor activity namespace: molecular_function def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] synonym: "PAF receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004993 name: G protein-coupled serotonin receptor activity namespace: molecular_function alt_id: GO:0001585 alt_id: GO:0016609 def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099589 ! serotonin receptor activity relationship: has_part GO:0051378 ! serotonin binding relationship: part_of GO:0098664 ! G protein-coupled serotonin receptor signaling pathway [Term] id: GO:0004994 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin] synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin] is_a: GO:0008188 ! neuropeptide receptor activity relationship: part_of GO:0038170 ! somatostatin signaling pathway [Term] id: GO:0004995 name: tachykinin receptor activity namespace: molecular_function def: "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] is_a: GO:0008188 ! neuropeptide receptor activity relationship: part_of GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0004996 name: thyroid-stimulating hormone receptor activity namespace: molecular_function def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "thyroid stimulating hormone receptor activity" EXACT [] synonym: "thyrotropin receptor" EXACT [] synonym: "TSH receptor activity" EXACT [] xref: Wikipedia:Thyrotropin_receptor is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity relationship: part_of GO:0038194 ! thyroid-stimulating hormone signaling pathway [Term] id: GO:0004997 name: thyrotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004998 name: transferrin receptor activity namespace: molecular_function def: "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0004999 name: vasoactive intestinal polypeptide receptor activity namespace: molecular_function def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function alt_id: GO:0016931 def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0005001 name: transmembrane receptor protein tyrosine phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity [Term] id: GO:0005003 name: ephrin receptor activity namespace: molecular_function def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "Eph receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0048013 ! ephrin receptor signaling pathway [Term] id: GO:0005004 name: GPI-linked ephrin receptor activity namespace: molecular_function def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "GPI-linked Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005005 name: transmembrane-ephrin receptor activity namespace: molecular_function def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "transmembrane-Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005006 name: epidermal growth factor-activated receptor activity namespace: molecular_function alt_id: GO:0005023 def: "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "EGF receptor activity" EXACT [] synonym: "EGFR" EXACT [] synonym: "epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "TGF-alpha receptor activity" EXACT [] synonym: "transforming growth factor-alpha receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0048408 ! epidermal growth factor binding relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0005007 name: fibroblast growth factor-activated receptor activity namespace: molecular_function def: "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "FGF receptor activity" EXACT [] synonym: "FGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "FGFR" EXACT [] synonym: "fibroblast growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0017134 ! fibroblast growth factor binding relationship: part_of GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0005008 name: hepatocyte growth factor-activated receptor activity namespace: molecular_function def: "Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "hepatocyte growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "HGF receptor activity" EXACT [] synonym: "HGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0036458 ! hepatocyte growth factor binding relationship: part_of GO:0048012 ! hepatocyte growth factor receptor signaling pathway [Term] id: GO:0005009 name: insulin-activated receptor activity namespace: molecular_function def: "Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "insulin receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0016500 ! protein-hormone receptor activity relationship: has_part GO:0043559 ! insulin binding relationship: part_of GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0005010 name: insulin-like growth factor-activated receptor activity namespace: molecular_function def: "Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "IGF receptor activity" EXACT [] synonym: "IGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "insulin-like growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0005520 ! insulin-like growth factor binding relationship: part_of GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0005011 name: macrophage colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling] synonym: "CSF-1" NARROW [] synonym: "Fms" NARROW [] synonym: "M-CSF receptor activity" EXACT [GOC:bf] synonym: "macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0038145 ! macrophage colony-stimulating factor signaling pathway [Term] id: GO:0005012 name: obsolete Neu/ErbB-2 receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of receptor rather than an activity. synonym: "Neu/ErbB-2 receptor activity" EXACT [] is_obsolete: true consider: GO:0043125 [Term] id: GO:0005013 name: obsolete neurotrophin TRK receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRK receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0019838 consider: GO:0043121 [Term] id: GO:0005014 name: obsolete neurotrophin TRKA receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKA receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 consider: GO:0048406 [Term] id: GO:0005015 name: obsolete neurotrophin TRKB receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKB receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 consider: GO:0048403 [Term] id: GO:0005016 name: obsolete neurotrophin TRKC receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKC receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 [Term] id: GO:0005017 name: platelet-derived growth factor-activated receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "PDGF receptor activity" EXACT [] synonym: "PDGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "PDGFR activity" EXACT [] synonym: "platelet-derived growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0048407 ! platelet-derived growth factor binding relationship: part_of GO:0036120 ! cellular response to platelet-derived growth factor stimulus relationship: part_of GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0005018 name: platelet-derived growth factor alpha-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961] synonym: "PDGF alpha-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity relationship: part_of GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway [Term] id: GO:0005019 name: platelet-derived growth factor beta-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "betaPDGF receptor activity" RELATED [PMID:10372961] synonym: "PDGF beta-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity relationship: part_of GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway [Term] id: GO:0005020 name: stem cell factor receptor activity namespace: molecular_function def: "Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217] synonym: "KIT" RELATED [PR:000009345] synonym: "KIT ligand receptor activity" EXACT [PR:000009345] synonym: "KL receptor activity" EXACT [PR:000009345] synonym: "SCF receptor activity" EXACT [PR:000009345] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0038109 ! Kit signaling pathway [Term] id: GO:0005021 name: vascular endothelial growth factor-activated receptor activity namespace: molecular_function def: "Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "vascular endothelial growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "VEGF receptor activity" EXACT [] synonym: "VEGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "VEGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: has_part GO:0038085 ! vascular endothelial growth factor binding relationship: part_of GO:0038084 ! vascular endothelial growth factor signaling pathway [Term] id: GO:0005024 name: transforming growth factor beta-activated receptor activity namespace: molecular_function def: "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "TGF-beta receptor activity" EXACT [] synonym: "TGFbeta receptor activity" EXACT [] synonym: "TGFbeta-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "TGFbetaR" EXACT [] synonym: "transforming growth factor beta receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0005025 name: transforming growth factor beta receptor activity, type I namespace: molecular_function def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:R-HSA-170846] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "type I TGF-beta receptor activity" EXACT [] synonym: "type I TGFbeta receptor activity" EXACT [] synonym: "type I transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity [Term] id: GO:0005026 name: transforming growth factor beta receptor activity, type II namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:R-HSA-170861] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "type II TGF-beta receptor activity" EXACT [] synonym: "type II TGFbeta receptor activity" EXACT [] synonym: "type II transforming growth factor beta receptor activity" EXACT [] xref: Reactome:R-HSA-170843 "TGFBR2 phosphorylates TGFBR1" is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity relationship: has_part GO:0050431 ! transforming growth factor beta binding [Term] id: GO:0005027 name: obsolete NGF/TNF (6 C-domain) receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a protein family rather than a molecular function. synonym: "NGF/TNF (6 C-domain) receptor activity" EXACT [] is_obsolete: true consider: GO:0005031 [Term] id: GO:0005028 name: obsolete CD40 receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "CD40 receptor activity" EXACT [] is_obsolete: true consider: GO:0042615 [Term] id: GO:0005029 name: obsolete CD27 receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "CD27 receptor activity" EXACT [] is_obsolete: true consider: GO:0042614 [Term] id: GO:0005030 name: neurotrophin receptor activity namespace: molecular_function def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0043121 ! neurotrophin binding relationship: part_of GO:0038179 ! neurotrophin signaling pathway [Term] id: GO:0005031 name: tumor necrosis factor-activated receptor activity namespace: molecular_function alt_id: GO:0005032 alt_id: GO:0005033 def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] synonym: "TNF receptor activity" EXACT [] synonym: "TNF receptor activity, type I" NARROW [] synonym: "TNF receptor activity, type II" NARROW [] synonym: "tumor necrosis factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "tumor necrosis factor receptor activity, type I" NARROW [] synonym: "tumor necrosis factor receptor activity, type II" NARROW [] is_a: GO:0005035 ! death receptor activity relationship: has_part GO:0043120 ! tumor necrosis factor binding relationship: part_of GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0005034 name: osmosensor activity namespace: molecular_function def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb] xref: MIPS_funcat:34.11.03.13 is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0005035 name: death receptor activity namespace: molecular_function def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153] synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0012501 ! programmed cell death [Term] id: GO:0005037 name: obsolete death receptor adaptor protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor adaptor protein activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005038 name: obsolete death receptor interacting protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor interacting protein activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005039 name: obsolete death receptor-associated factor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor-associated factor activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005041 name: low-density lipoprotein particle receptor activity namespace: molecular_function alt_id: GO:0008032 def: "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis." [GOC:bf, ISBN:0198506732] synonym: "LDL receptor" EXACT [] synonym: "LDLR activity" EXACT [GOC:bf] synonym: "low-density lipoprotein receptor activity" RELATED [] xref: Reactome:R-HSA-2404131 "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol" xref: Reactome:R-HSA-2424254 "LDLR transports extracellular CR:atREs to cytosol" xref: Wikipedia:LDL_receptor is_a: GO:0030228 ! lipoprotein particle receptor activity relationship: has_part GO:0030169 ! low-density lipoprotein particle binding [Term] id: GO:0005042 name: netrin receptor activity namespace: molecular_function def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0038007 ! netrin-activated signaling pathway [Term] id: GO:0005043 name: netrin receptor activity involved in chemorepulsion namespace: molecular_function def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling] synonym: "netrin receptor activity involved in negative chemotaxis" EXACT [GOC:bf] synonym: "repulsive netrin receptor activity" EXACT [GOC:bf] is_a: GO:0005042 ! netrin receptor activity intersection_of: GO:0005042 ! netrin receptor activity intersection_of: part_of GO:0050919 ! negative chemotaxis relationship: part_of GO:0050919 ! negative chemotaxis [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. subset: goslim_chembl synonym: "macrophage receptor activity" NARROW [] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0005045 name: obsolete endoplasmic reticulum receptor activity namespace: molecular_function def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] comment: This term was made obsolete because it represents cellular component and molecular function information. synonym: "endoplasmic reticulum receptor activity" EXACT [] is_obsolete: true consider: GO:0038024 [Term] id: GO:0005046 name: KDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] synonym: "KDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0005047 name: signal recognition particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732] comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. synonym: "docking protein" BROAD [] synonym: "signal recognition particle receptor" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0005048 name: signal sequence binding namespace: molecular_function alt_id: GO:0008249 def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] synonym: "leader sequence binding" NARROW [] synonym: "protein signal sequence binding" NARROW [] synonym: "signal sequence receptor" NARROW [] is_a: GO:0042277 ! peptide binding [Term] id: GO:0005049 name: nuclear export signal receptor activity namespace: molecular_function alt_id: GO:0008262 def: "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport] comment: Changed parents, updated definition see https://github.com/geneontology/go-ontology/issues/14336 synonym: "exportin activity" RELATED [] synonym: "importin-alpha binding" RELATED [] synonym: "importin-alpha export receptor activity" NARROW [GO:0008262] synonym: "NES receptor" EXACT [] is_a: GO:0140142 ! nucleocytoplasmic carrier activity intersection_of: GO:0140142 ! nucleocytoplasmic carrier activity intersection_of: part_of GO:0051168 ! nuclear export relationship: part_of GO:0051168 ! nuclear export [Term] id: GO:0005050 name: obsolete peroxisome receptor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "peroxisome receptor" EXACT [] is_obsolete: true consider: GO:0005777 consider: GO:0038023 [Term] id: GO:0005052 name: peroxisome matrix targeting signal-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540] synonym: "peroxisome targeting signal-1 binding" EXACT [] synonym: "peroxisome targeting signal-1 receptor" NARROW [] synonym: "PEX5" NARROW [] synonym: "PTS1 binding" EXACT [PMID:14709540] synonym: "PTS1 receptor" NARROW [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005053 name: peroxisome matrix targeting signal-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540] synonym: "peroxisome targeting signal-2 binding" EXACT [] synonym: "peroxisome targeting signal-2 receptor" NARROW [] synonym: "PEX7" NARROW [] synonym: "PTS2 binding" EXACT [PMID:14709540] synonym: "PTS2 receptor" EXACT [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005054 name: obsolete peroxisome integral membrane receptor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "Pas20p" RELATED [] synonym: "peroxisome integral membrane receptor" EXACT [] is_obsolete: true consider: GO:0038023 [Term] id: GO:0005055 name: laminin receptor activity namespace: molecular_function def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. is_a: GO:0098631 ! cell adhesion mediator activity relationship: has_part GO:0043236 ! laminin binding [Term] id: GO:0005056 name: tiggrin receptor activity namespace: molecular_function def: "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0005057 name: obsolete signal transducer activity, downstream of receptor namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "intracellular signal transducer activity" EXACT [GOC:bf] synonym: "receptor signaling protein activity" EXACT [] synonym: "receptor signalling protein activity" EXACT [] is_obsolete: true [Term] id: GO:0005061 name: obsolete aryl hydrocarbon receptor nuclear translocator activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "aryl hydrocarbon receptor nuclear translocator activity" EXACT [] is_obsolete: true [Term] id: GO:0005065 name: obsolete heterotrimeric G-protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a cellular component and not a molecular function. synonym: "heterotrimeric G-protein" EXACT [] is_obsolete: true replaced_by: GO:0005834 [Term] id: GO:0005066 name: obsolete transmembrane receptor protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein tyrosine kinase signaling protein activity" EXACT [] synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0007169 consider: GO:0035556 [Term] id: GO:0005068 name: transmembrane receptor protein tyrosine kinase adaptor activity namespace: molecular_function alt_id: GO:0005069 def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848] synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT [] synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED [] is_a: GO:0030159 ! receptor signaling complex adaptor activity is_a: GO:0030971 ! receptor tyrosine kinase binding relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0005070 name: SH3/SH2 adaptor activity namespace: molecular_function def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] synonym: "SH3/SH2 adaptor protein activity" NARROW [] is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005071 name: obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein serine/threonine kinase signaling protein activity" EXACT [] synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0007178 consider: GO:0035556 [Term] id: GO:0005072 name: transforming growth factor beta receptor, cytoplasmic mediator activity namespace: molecular_function def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] comment: Note that this term and its children are useful for annotating proteins of the SMAD family. synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0005073 name: obsolete common-partner SMAD protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. synonym: "common-partner SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030616 [Term] id: GO:0005074 name: obsolete inhibitory SMAD protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. synonym: "inhibitory SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030617 [Term] id: GO:0005075 name: obsolete pathway-specific SMAD protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a family of gene products. synonym: "pathway-specific SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030618 [Term] id: GO:0005076 name: obsolete receptor signaling protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein serine/threonine kinase signaling protein activity" EXACT [] synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005077 name: obsolete MAP-kinase anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "MAP-kinase anchor protein activity" EXACT [] synonym: "MAP-kinase anchoring activity" EXACT [] is_obsolete: true consider: GO:0008104 consider: GO:0051019 [Term] id: GO:0005078 name: MAP-kinase scaffold activity namespace: molecular_function def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] synonym: "MAP-kinase scaffold protein activity" EXACT [] is_a: GO:0019900 ! kinase binding is_a: GO:0035591 ! signaling adaptor activity relationship: part_of GO:0043410 ! positive regulation of MAPK cascade [Term] id: GO:0005079 name: obsolete protein kinase A anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "A-kinase anchor protein activity" EXACT [] synonym: "AKAP activity" EXACT [] synonym: "protein kinase A anchoring activity" EXACT [] is_obsolete: true consider: GO:0008104 consider: GO:0051018 [Term] id: GO:0005080 name: protein kinase C binding namespace: molecular_function alt_id: GO:0072568 alt_id: GO:0072569 alt_id: GO:0097024 def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl] synonym: "PKC alpha binding" EXACT [] synonym: "PKC binding" EXACT [] synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr] synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr] synonym: "protein kinase C alpha binding" NARROW [] synonym: "protein kinase C delta binding" NARROW [] synonym: "protein kinase C eta binding" NARROW [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0005081 name: obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein serine/threonine phosphatase signaling protein activity" EXACT [] synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005082 name: obsolete receptor signaling protein tyrosine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein tyrosine phosphatase signaling protein activity" EXACT [] synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0008433 alt_id: GO:0016219 alt_id: GO:0019839 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] comment: Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product. subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "GDP-dissociation stimulator activity" EXACT [] synonym: "GDS" EXACT [] synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: MIPS_funcat:18.02.03 xref: Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA" xref: Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP" xref: Reactome:R-HSA-1433415 "Activation of RAC1" xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity" xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-187746 "RIT/RIN are activated" xref: Reactome:R-HSA-2029445 "Activation of CDC42 by unknown mechanism" xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV" xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO" xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding" xref: Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor" xref: Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3" xref: Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt" xref: Reactome:R-HSA-2730840 "Activation of RAC1 by VAV" xref: Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs" xref: Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs" xref: Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11" xref: Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi" xref: Reactome:R-HSA-389348 "Activation of Rac1 by pVav1" xref: Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1" xref: Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12" xref: Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it" xref: Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it" xref: Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it" xref: Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA" xref: Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor" xref: Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange" xref: Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq" xref: Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-416530 "GPR40:fatty acid activates Gq" xref: Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1" xref: Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t" xref: Reactome:R-HSA-428750 "Gq activation by TP receptor" xref: Reactome:R-HSA-428917 "G13 activation by TP receptor" xref: Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases" xref: Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases" xref: Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases" xref: Reactome:R-HSA-445064 "Activation of Rac1 by VAV2" xref: Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism" xref: Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1" xref: Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it" xref: Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1" xref: Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange" xref: Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange" xref: Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz" xref: Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13" xref: Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange" xref: Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex" xref: Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18" xref: Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1" xref: Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET" xref: Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET" xref: Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1" xref: Reactome:R-HSA-8875591 "DOCK7 activates RAC1" xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated" xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t" xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)" xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs" is_a: GO:0051020 ! GTPase binding is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0005086 name: ARF guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation" xref: Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4" xref: Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF" xref: Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005087 name: Ran guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP" xref: Wikipedia:RCC1 is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0008536 ! Ran GTPase binding [Term] id: GO:0005088 name: Ras guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)" xref: Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)" xref: Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4" xref: Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers" xref: Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers." xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers" xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1" xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)" xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" xref: Reactome:R-HSA-186834 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)" xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)" xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)" xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)" xref: Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras" xref: Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS" xref: Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)" xref: Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)" xref: Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655277 "Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange" xref: Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS" xref: Reactome:R-HSA-8853307 "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1" xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS" xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0005089 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] subset: goslim_chembl synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth" xref: Reactome:R-HSA-194913 "GEFs activate Rho GTPase:GDP" xref: Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF" xref: Reactome:R-HSA-418850 "Activation of Cdc42" xref: Reactome:R-HSA-418856 "Activation of Rac1" xref: Reactome:R-HSA-419166 "GEFs activate RhoA,B,C" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0005090 name: Sar guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005091 name: guanyl-nucleotide exchange factor adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] is_a: GO:0030674 ! protein binding, bridging is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005092 name: GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] synonym: "GDI" EXACT [] is_a: GO:0030695 ! GTPase regulator activity relationship: positively_regulates GO:0019003 ! GDP binding [Term] id: GO:0005093 name: Rab GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005094 name: Rho GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005095 name: GTPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] synonym: "GIP" BROAD [] xref: MIPS_funcat:18.02.01.02.01 is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0030695 ! GTPase regulator activity relationship: negatively_regulates GO:0003924 ! GTPase activity relationship: part_of GO:0034260 ! negative regulation of GTPase activity [Term] id: GO:0005096 name: GTPase activator activity namespace: molecular_function alt_id: GO:0005097 alt_id: GO:0005098 alt_id: GO:0005099 alt_id: GO:0005100 alt_id: GO:0005101 alt_id: GO:0008060 alt_id: GO:0017123 alt_id: GO:0030675 alt_id: GO:0046582 def: "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. synonym: "ARF GAP activity" NARROW [GOC:pg] synonym: "ARF GTPase activator activity" NARROW [] synonym: "GAP activity" EXACT [] synonym: "Rab GAP activity" NARROW [GOC:pg] synonym: "Rab GTPase activator activity" NARROW [] synonym: "Rac GAP activity" NARROW [GOC:pg] synonym: "Rac GTPase activator activity" NARROW [] synonym: "Ral GAP activity" NARROW [GOC:pg] synonym: "Ral GTPase activator activity" NARROW [] synonym: "Ran GAP activity" NARROW [GOC:pg] synonym: "Ran GTPase activator activity" NARROW [] synonym: "RanGAP" NARROW [] synonym: "Rap GAP activity" NARROW [GOC:pg] synonym: "Rap GTPase activator activity" NARROW [] synonym: "Ras GAP activity" NARROW [GOC:pg] synonym: "Ras GTPase activator activity" NARROW [] synonym: "Rho GAP activity" NARROW [GOC:pg] synonym: "Rho GTPase activator activity" NARROW [] synonym: "Sar GAP activity" NARROW [GOC:pg] synonym: "Sar GTPase activator activity" NARROW [] xref: MIPS_funcat:18.02.01.01.01 xref: Reactome:R-HSA-194922 "GAPs inactivate Rho GTPase:GTP by hydrolysis" xref: Reactome:R-HSA-392513 "Rap1 signal termination by Rap1GAPs" xref: Reactome:R-HSA-399935 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity" xref: Reactome:R-HSA-4093339 "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it" xref: Reactome:R-HSA-416546 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity" xref: Reactome:R-HSA-416559 "Inactivation of Rho-GTP by p190RhoGAP" xref: Reactome:R-HSA-428522 "Inactivation of RAC1" xref: Reactome:R-HSA-428533 "Inactivation of CDC42" xref: Reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3" xref: Reactome:R-HSA-8985594 "MYO9B inactivates RHOA" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0030695 ! GTPase regulator activity relationship: part_of GO:0043547 ! positive regulation of GTPase activity relationship: positively_regulates GO:0003924 ! GTPase activity [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005104 name: fibroblast growth factor receptor binding namespace: molecular_function alt_id: GO:0001521 alt_id: GO:0005162 def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. synonym: "FGF receptor binding" EXACT [] synonym: "FGFR binding" EXACT [] synonym: "FGFR ligand" NARROW [] synonym: "fibroblast growth factor" BROAD [] synonym: "fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005105 name: type 1 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). synonym: "breathless binding" NARROW [] synonym: "breathless ligand" NARROW [] synonym: "FGFR1 binding" BROAD [] synonym: "FGFR1 ligand" NARROW [] synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005106 name: obsolete ephrin namespace: molecular_function def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ephrin" EXACT [] is_obsolete: true consider: GO:0046875 [Term] id: GO:0005107 name: obsolete GPI-linked ephrin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "GPI-linked ephrin" EXACT [] is_obsolete: true consider: GO:0046658 consider: GO:0046875 [Term] id: GO:0005108 name: obsolete transmembrane ephrin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "transmembrane ephrin" EXACT [] is_obsolete: true consider: GO:0005887 consider: GO:0046875 [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function alt_id: GO:0005110 def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb, PR:000001315] subset: goslim_chembl synonym: "frizzled ligand" NARROW [] synonym: "frizzled-2 binding" NARROW [] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] synonym: "fz2 binding" NARROW [] synonym: "fz2 ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0005111 name: type 2 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). synonym: "FGFR2 binding" EXACT [] synonym: "FGFR2 ligand" NARROW [] synonym: "heartless binding" EXACT [] synonym: "heartless ligand" NARROW [] synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005112 name: Notch binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] synonym: "N binding" EXACT [] synonym: "N ligand" NARROW [] synonym: "Notch ligand" NARROW [] synonym: "Notch receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005113 name: patched binding namespace: molecular_function def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] synonym: "patched ligand" NARROW [] synonym: "ptc binding" EXACT [] synonym: "ptc ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005114 name: type II transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] synonym: "punt binding" NARROW [] synonym: "punt ligand" NARROW [] synonym: "TGF-beta type II binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor type II binding" EXACT [] synonym: "type II TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0005115 name: receptor tyrosine kinase-like orphan receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw] synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] synonym: "Ror binding" BROAD [] synonym: "Ror ligand" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005117 name: wishful thinking binding namespace: molecular_function def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] synonym: "SE20 receptor binding" NARROW [] synonym: "wishful thinking ligand" NARROW [] synonym: "Wit binding" EXACT [] synonym: "Wit ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005118 name: sevenless binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175] synonym: "sev binding" EXACT [] synonym: "sev ligand" NARROW [] synonym: "sevenless ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005119 name: smoothened binding namespace: molecular_function def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] synonym: "smo binding" EXACT [] synonym: "smo ligand" NARROW [] synonym: "smoothened ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0005121 name: Toll binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] synonym: "Tl binding" EXACT [] synonym: "Toll ligand" NARROW [] synonym: "Toll receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005122 name: torso binding namespace: molecular_function def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] subset: goslim_chembl synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005124 name: scavenger receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] synonym: "scavenger receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] xref: MIPS_funcat:40.02.03.01 is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cytokine receptor." [GOC:mah, GOC:vw] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005127 name: ciliary neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai] synonym: "ciliary neurotrophic factor" NARROW [] synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005128 name: erythropoietin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai] synonym: "erythropoietin" NARROW [] synonym: "erythropoietin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005129 name: granulocyte macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "GM-CSF receptor binding" EXACT [GOC:vk] synonym: "GM-CSF receptor ligand" NARROW [] synonym: "GMC-SF receptor ligand" NARROW [] synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor" NARROW [] synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005130 name: granulocyte colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai] synonym: "G-CSF receptor ligand" EXACT [] synonym: "GC-SF receptor ligand" EXACT [] synonym: "granulocyte colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte colony-stimulating factor" NARROW [] synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005131 name: growth hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai] synonym: "growth hormone" NARROW [] synonym: "growth hormone receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0005132 name: type I interferon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368] synonym: "IFNAR binding" RELATED [PMID:17502368] synonym: "IFNAR1 binding" NARROW [PR:000008922] synonym: "IFNAR2 binding" NARROW [PR:000008923] synonym: "interferon-alpha/beta" NARROW [] synonym: "interferon-alpha/beta receptor binding" EXACT [PR:000008922, PR:000008923] synonym: "interferon-alpha/beta receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005133 name: interferon-gamma receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai] synonym: "interferon-gamma" NARROW [] synonym: "interferon-gamma receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005134 name: interleukin-2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai] synonym: "IL-2" NARROW [] synonym: "interleukin-2 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005135 name: interleukin-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai] synonym: "IL-3" NARROW [] synonym: "interleukin-3 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005136 name: interleukin-4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai] synonym: "IL-4" NARROW [] synonym: "interleukin-4 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005139 name: interleukin-7 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai] synonym: "IL-7" NARROW [] synonym: "interleukin-7 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005140 name: interleukin-9 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai] synonym: "IL-9" NARROW [] synonym: "interleukin-9 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005141 name: interleukin-10 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai] synonym: "IL-10" NARROW [] synonym: "interleukin-10 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005142 name: interleukin-11 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai] synonym: "IL-11" NARROW [] synonym: "interleukin-11 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005143 name: interleukin-12 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai] synonym: "IL-12" NARROW [] synonym: "interleukin-12 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005144 name: interleukin-13 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai] synonym: "IL-13" NARROW [] synonym: "interleukin-13 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005145 name: interleukin-14 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai] synonym: "IL-14" NARROW [] synonym: "interleukin-14 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005146 name: leukemia inhibitory factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai] synonym: "leukemia inhibitory factor" NARROW [] synonym: "leukemia inhibitory factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005147 name: oncostatin-M receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai] synonym: "oncostatin-M" NARROW [] synonym: "oncostatin-M receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005148 name: prolactin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai] synonym: "prolactin" NARROW [] synonym: "prolactin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005149 name: interleukin-1 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators] synonym: "IL-1" NARROW [] synonym: "interleukin-1 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005150 name: interleukin-1, type I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type I" NARROW [] synonym: "interleukin-1, type I receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005151 name: interleukin-1, type II receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type II" NARROW [] synonym: "interleukin-1, type II receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005152 name: interleukin-1 receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] synonym: "IL-1ra" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0019966 ! interleukin-1 binding is_a: GO:0048019 ! receptor antagonist activity relationship: part_of GO:0001960 ! negative regulation of cytokine-mediated signaling pathway [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators] subset: goslim_chembl synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] subset: goslim_chembl synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005155 name: obsolete epidermal growth factor receptor activating ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor activating ligand activity" EXACT [] synonym: "EGFR activating ligand activity" EXACT [] synonym: "epidermal growth factor receptor activating ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0030297 consider: GO:0045741 [Term] id: GO:0005156 name: obsolete epidermal growth factor receptor inhibiting ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor inhibiting ligand activity" EXACT [] synonym: "EGFR inhibiting ligand activity" EXACT [] synonym: "epidermal growth factor receptor inhibiting ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0007175 consider: GO:0030293 [Term] id: GO:0005157 name: macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "M-CSF receptor binding" EXACT [GOC:vk] synonym: "macrophage colony stimulating factor receptor binding" EXACT [] synonym: "macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005158 name: insulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] synonym: "insulin receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005159 name: insulin-like growth factor receptor binding namespace: molecular_function alt_id: GO:0005067 def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl] synonym: "IGF receptor binding" EXACT [] synonym: "insulin-like growth factor" NARROW [] synonym: "insulin-like growth factor receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005160 name: transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai] synonym: "activin" RELATED [] synonym: "inhibin" RELATED [] synonym: "TGF-beta receptor binding" EXACT [] synonym: "TGFbeta receptor binding" EXACT [] synonym: "transforming growth factor beta" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] xref: Reactome:R-HSA-170861 "Dimeric TGF-beta-1 binds to the receptor" is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005161 name: platelet-derived growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai] synonym: "PDGF" NARROW [] synonym: "PDGF receptor binding" EXACT [] synonym: "PDGFR binding" EXACT [] synonym: "platelet-derived growth factor" NARROW [] synonym: "platelet-derived growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005163 name: nerve growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015] synonym: "nerve growth factor receptor ligand" NARROW [] synonym: "neurotrophin" NARROW [] synonym: "NGF receptor binding" EXACT [] is_a: GO:0005123 ! death receptor binding is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai] subset: goslim_chembl synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005165 name: neurotrophin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai] synonym: "neurotrophin" NARROW [] synonym: "neurotrophin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005166 name: neurotrophin p75 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai] synonym: "neurotrophin p75 receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005167 name: neurotrophin TRK receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai] synonym: "neurotrophin TRK receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005168 name: neurotrophin TRKA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai] synonym: "neurotrophin TRKA receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005169 name: neurotrophin TRKB receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai] synonym: "neurotrophin TRKB receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005170 name: neurotrophin TRKC receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai] synonym: "neurotrophin TRKC receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005171 name: hepatocyte growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai] synonym: "hepatocyte growth factor" NARROW [] synonym: "hepatocyte growth factor receptor ligand" NARROW [] synonym: "HGF receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005174 name: CD40 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005175 name: CD27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005176 name: ErbB-2 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] synonym: "ErbB-2 class receptor ligand" NARROW [] synonym: "HER2 receptor binding" EXACT [] synonym: "HER2 receptor ligand" NARROW [] synonym: "Neu receptor binding" EXACT [] synonym: "Neu receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005177 name: obsolete neuroligin namespace: molecular_function def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] synonym: "neuroligin" EXACT [] is_obsolete: true consider: GO:0042043 [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb] subset: goslim_chembl synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding is_a: GO:0050839 ! cell adhesion molecule binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005180 name: obsolete peptide hormone namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "peptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005181 name: obsolete glycopeptide hormone namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "glycopeptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005182 name: obsolete lipopeptide hormone namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "lipopeptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005183 name: gonadotropin hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone] synonym: "GnRH activity" EXACT [ISBN:0198506732] synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [GOC:dph] synonym: "LH/FSH-RF" EXACT [ISBN:0198506732] synonym: "LHRH activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] subset: goslim_chembl synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005185 name: neurohypophyseal hormone activity namespace: molecular_function def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634] synonym: "neurohypophysial hormone activity" EXACT [GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0005186 name: pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005187 name: obsolete storage protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. synonym: "storage protein" EXACT [] is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0005188 name: obsolete larval serum protein (sensu Insecta) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "arylphorin" NARROW [] synonym: "larval serum protein (sensu Insecta)" EXACT [] is_obsolete: true [Term] id: GO:0005189 name: obsolete milk protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "milk protein" EXACT [] is_obsolete: true [Term] id: GO:0005190 name: obsolete seminal fluid protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "seminal fluid protein" EXACT [] is_obsolete: true [Term] id: GO:0005191 name: obsolete acidic epididymal glycoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. synonym: "acidic epididymal glycoprotein" EXACT [] is_obsolete: true [Term] id: GO:0005192 name: obsolete urinary protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "urinary protein" EXACT [] is_obsolete: true [Term] id: GO:0005193 name: obsolete major urinary protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "major urinary protein" EXACT [] is_obsolete: true [Term] id: GO:0005194 name: obsolete cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. synonym: "cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 consider: GO:0098631 [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell." [GOC:mah, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:16.07 is_a: GO:0003674 ! molecular_function [Term] id: GO:0005199 name: structural constituent of cell wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005618 ! cell wall relationship: occurs_in GO:0005618 ! cell wall [Term] id: GO:0005200 name: structural constituent of cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] subset: goslim_drosophila is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005856 ! cytoskeleton intersection_of: part_of GO:0007010 ! cytoskeleton organization relationship: occurs_in GO:0005856 ! cytoskeleton relationship: part_of GO:0007010 ! cytoskeleton organization [Term] id: GO:0005201 name: extracellular matrix structural constituent namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019 subset: goslim_drosophila synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] synonym: "extracellular matrix glycoprotein" NARROW [] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0031012 ! extracellular matrix relationship: occurs_in GO:0031012 ! extracellular matrix [Term] id: GO:0005202 name: obsolete collagen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "collagen" EXACT [] is_obsolete: true consider: GO:0005581 [Term] id: GO:0005203 name: obsolete proteoglycan namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005204 name: obsolete chondroitin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulfate proteoglycan" EXACT [] synonym: "chondroitin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005205 name: obsolete chondroitin sulfate/dermatan sulfate proteoglycan namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulfate/dermatan sulfate proteoglycan" EXACT [] synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005206 name: obsolete heparin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "heparin sulfate proteoglycan" EXACT [] synonym: "heparin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005207 name: obsolete extracellular matrix glycoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes localization and modification rather than activity. synonym: "extracellular matrix glycoprotein" EXACT [] is_obsolete: true consider: GO:0005201 [Term] id: GO:0005208 name: obsolete amyloid protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "amyloid protein" EXACT [] is_obsolete: true [Term] id: GO:0005209 name: obsolete plasma protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "plasma protein" EXACT [] is_obsolete: true [Term] id: GO:0005211 name: obsolete plasma glycoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. synonym: "plasma glycoprotein" EXACT [] is_obsolete: true [Term] id: GO:0005212 name: structural constituent of eye lens namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005213 name: structural constituent of chorion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] synonym: "structural protein of chorion" NARROW [] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0042600 ! chorion relationship: occurs_in GO:0042600 ! chorion [Term] id: GO:0005214 name: structural constituent of chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "carrier" RELATED [] xref: EC:7 xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005216 name: ion channel activity namespace: molecular_function def: "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: MIPS_funcat:20.03.01.01 is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015267 ! channel activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0005217 name: intracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005219 name: ryanodine-sensitive calcium-release channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] synonym: "caffeine-sensitive calcium-release channel" RELATED [] synonym: "ryanodine receptor" NARROW [] xref: Reactome:R-HSA-2855020 "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol" is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005220 name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: molecular_function alt_id: GO:0008095 def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor] synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT [] synonym: "InsP3 receptor" EXACT [GOC:bf] synonym: "IP3 receptor activity" EXACT [] is_a: GO:0015278 ! calcium-release channel activity relationship: has_part GO:0070679 ! inositol 1,4,5 trisphosphate binding relationship: part_of GO:0048016 ! inositol phosphate-mediated signaling [Term] id: GO:0005221 name: intracellular cyclic nucleotide activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] xref: Reactome:R-HSA-2514867 "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment" is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0005222 name: intracellular cAMP-activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "HCN channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "hyperpolarization-activated cyclic nucleotide-gated channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] synonym: "intracellular cAMP activated cation channel activity" EXACT [] synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005223 name: intracellular cGMP-activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "intracellular cGMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005225 name: volume-sensitive anion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb] synonym: "volume-regulated channel" BROAD [] xref: Reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region" is_a: GO:0005253 ! anion channel activity [Term] id: GO:0005227 name: calcium activated cation channel activity namespace: molecular_function def: "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] is_a: GO:0005261 ! cation channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005228 name: intracellular sodium activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005229 name: intracellular calcium activated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region" is_a: GO:0022839 ! ion gated channel activity is_a: GO:0061778 ! intracellular chloride channel activity [Term] id: GO:0005230 name: extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005231 name: excitatory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070] xref: Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors" xref: Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors" xref: Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors" xref: Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell" xref: Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors" is_a: GO:0005230 ! extracellular ligand-gated ion channel activity intersection_of: GO:0005230 ! extracellular ligand-gated ion channel activity intersection_of: part_of GO:0060079 ! excitatory postsynaptic potential relationship: part_of GO:0060079 ! excitatory postsynaptic potential [Term] id: GO:0005234 name: extracellularly glutamate-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. synonym: "extracellular-glutamate-gated ion channel activity" EXACT [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0005237 name: inhibitory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005240 name: obsolete glycine receptor-associated protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a molecular function. synonym: "glycine receptor-associated protein" EXACT [] is_obsolete: true consider: GO:0005515 [Term] id: GO:0005241 name: obsolete inward rectifier channel namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "inward rectifier channel" EXACT [] is_obsolete: true consider: GO:0005242 [Term] id: GO:0005242 name: inward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] synonym: "Kir channel activity" EXACT [GOC:cb] xref: Reactome:R-HSA-1296045 "Activation of Potassium transport channels" xref: Reactome:R-HSA-1296046 "KCNJs transport K+ from the extracellular region to cytosol" xref: Reactome:R-HSA-1369017 "Activation of ATP sensitive Potassium channels in muscle cells" xref: Reactome:R-HSA-5678261 "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol" xref: Reactome:R-HSA-5678418 "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol" is_a: GO:0005249 ! voltage-gated potassium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0005243 name: gap junction channel activity namespace: molecular_function alt_id: GO:0015285 alt_id: GO:0015286 def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] synonym: "connexin" RELATED [] synonym: "innexin" NARROW [] synonym: "innexin channel activity" EXACT [] synonym: "intercellular channel" BROAD [] xref: Reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane" xref: Reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication" xref: Reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication" xref: Reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication" xref: Reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication" is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0005244 name: voltage-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022832 ! voltage-gated channel activity [Term] id: GO:0005245 name: voltage-gated calcium channel activity namespace: molecular_function alt_id: GO:0010173 alt_id: GO:0015270 def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "dihydropyridine-sensitive calcium channel activity" NARROW [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: Reactome:R-HSA-265645 "Calcium Influx through Voltage-gated Calcium Channels" xref: Reactome:R-HSA-5577213 "LTCC heteropentamer (open) transports Ca2+ from extracellular region to cytosol" is_a: GO:0005262 ! calcium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005246 name: calcium channel regulator activity namespace: molecular_function def: "Modulates the activity of a calcium channel." [GOC:mah] is_a: GO:0099106 ! ion channel regulator activity [Term] id: GO:0005247 name: voltage-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated chloride channel activity" EXACT [] synonym: "voltage-dependent chloride channel activity" EXACT [] xref: Reactome:R-HSA-2744228 "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" is_a: GO:0005254 ! chloride channel activity is_a: GO:0008308 ! voltage-gated anion channel activity [Term] id: GO:0005248 name: voltage-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] xref: Reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol" is_a: GO:0005272 ! sodium channel activity [Term] id: GO:0005249 name: voltage-gated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] xref: Reactome:R-HSA-1296127 "Activation of voltage gated Potassium channels" is_a: GO:0005267 ! potassium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005250 name: A-type (transient outward) potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region" is_a: GO:0015271 ! outward rectifier potassium channel activity [Term] id: GO:0005251 name: delayed rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] xref: Reactome:R-HSA-5577050 "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region" xref: Reactome:R-HSA-5577237 "KCNH2:KCNE transport K+ from cytosol to extracellular region" is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005252 name: open rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005253 name: anion channel activity namespace: molecular_function def: "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "non-selective anion channel activity" NARROW [] xref: Reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles" xref: Reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles" is_a: GO:0005216 ! ion channel activity is_a: GO:0015103 ! inorganic anion transmembrane transporter activity disjoint_from: GO:0005261 ! cation channel activity [Term] id: GO:0005254 name: chloride channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport" xref: Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol" xref: Reactome:R-HSA-975449 "GABRR pentamer:GABA transports extracellular Cl- to cytosol" is_a: GO:0005253 ! anion channel activity is_a: GO:0015108 ! chloride transmembrane transporter activity [Term] id: GO:0005260 name: intracellularly ATP-gated chloride channel activity namespace: molecular_function alt_id: GO:0005224 def: "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [EC:5.6.1.6, PMID:24727426, PMID:9922375, Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator] comment: https://github.com/geneontology/go-ontology/issues/14402 synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:5.6.1.6] synonym: "ATP-binding and phosphorylation-dependent chloride channel activity" EXACT [] synonym: "channel-conductance-controlling ATPase activity" EXACT [] synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:5.6.1.6] xref: EC:5.6.1.6 xref: MetaCyc:3.6.3.49-RXN is_a: GO:0005254 ! chloride channel activity is_a: GO:0099095 ! ligand-gated anion channel activity is_a: GO:0099142 ! intracellularly ATP-gated ion channel activity [Term] id: GO:0005261 name: cation channel activity namespace: molecular_function alt_id: GO:0015281 alt_id: GO:0015338 def: "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "cation diffusion facilitator activity" EXACT [] synonym: "non-selective cation channel activity" NARROW [] xref: Reactome:R-HSA-1168376 "STIM1 oligomerizes" xref: Reactome:R-HSA-1296043 "Activation of HCN channels" xref: Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol" xref: Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol" xref: Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7" xref: Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT" is_a: GO:0005216 ! ion channel activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0005262 name: calcium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol" xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma" xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels" xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol" xref: Reactome:R-HSA-5263618 "CACFD1 dimer transports Ca2+ from extracellular region to cytosol" xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix" is_a: GO:0005261 ! cation channel activity is_a: GO:0015085 ! calcium ion transmembrane transporter activity [Term] id: GO:0005267 name: potassium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells" xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermeidtance conductance" xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance" xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance" xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)" xref: Reactome:R-HSA-1299297 "Activation of THIK" xref: Reactome:R-HSA-1299304 "Activation of tandem pore domain in a weak inwardly rectifying K+ channels" xref: Reactome:R-HSA-1299318 "Activation of TASK" xref: Reactome:R-HSA-1299338 "Activation of TRESK" xref: Reactome:R-HSA-1299359 "Activation of TALK" xref: Reactome:R-HSA-2534365 "Slo3 Potassium Transport" xref: Reactome:R-HSA-5578910 "KCNK dimers transport K+ from cytosol to extracellular region" is_a: GO:0005261 ! cation channel activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity [Term] id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region" xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol" is_a: GO:0005261 ! cation channel activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0005274 name: allantoin:proton symporter activity namespace: molecular_function alt_id: GO:0015206 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] synonym: "allantoin permease activity" RELATED [] synonym: "allantoin uptake transmembrane transporter activity" NARROW [] synonym: "allantoin/allantoate transporter" BROAD [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0015720 ! allantoin transport [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005279 def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] xref: MIPS_funcat:20.01.11 is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015837 ! amine transport [Term] id: GO:0005276 name: obsolete vesicular amino acid:proton antiporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625] comment: The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions synonym: "hydrogen:vesicular amine antiporter activity" EXACT [] synonym: "vesicular hydrogen:amino acid antiporter activity" EXACT [] is_obsolete: true [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicle" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity [Term] id: GO:0005278 name: acetylcholine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:hydrogen antiporter activity" EXACT [] is_a: GO:0005277 ! acetylcholine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005280 name: amino acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] synonym: "cation/amino acid symporter" BROAD [] synonym: "hydrogen:amino acid symporter activity" EXACT [] xref: Reactome:R-HSA-8875623 "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix" is_a: GO:0005416 ! amino acid:cation symporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005281 name: obsolete general amino acid permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "general amino acid permease activity" EXACT [] synonym: "general amino acid transporter" BROAD [] is_obsolete: true replaced_by: GO:0015171 [Term] id: GO:0005283 name: amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005284 alt_id: GO:0005285 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "insulin-activated sodium/amino acid transporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid symporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid transporter activity" NARROW [] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "sodium/amino acid transporter activity" BROAD [] synonym: "sodium/excitatory amino acid cotransporter activity" BROAD [] synonym: "sodium/excitatory amino acid symporter activity" EXACT [] synonym: "sodium:amino acid symporter activity" EXACT [] synonym: "sodium:amino acid transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" NARROW [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005416 ! amino acid:cation symporter activity [Term] id: GO:0005287 name: high-affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity basic amino acid transmembrane transporter activity" EXACT [] synonym: "high-affinity basic amino acid transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity [Term] id: GO:0005289 name: high-affinity arginine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity arginine transmembrane transporter activity" EXACT [] synonym: "high-affinity arginine transporter activity" BROAD [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity [Term] id: GO:0005290 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity relationship: part_of GO:0089709 ! L-histidine transmembrane transport [Term] id: GO:0005291 name: high-affinity L-histidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity histidine permease activity" RELATED [] synonym: "high affinity L-histidine transmembrane transporter activity" EXACT [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0005290 ! L-histidine transmembrane transporter activity [Term] id: GO:0005292 name: high-affinity lysine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity lysine transmembrane transporter activity" EXACT [] synonym: "high affinity lysine transporter activity" BROAD [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015189 ! L-lysine transmembrane transporter activity [Term] id: GO:0005294 name: neutral L-amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "neutral L-amino acid porter activity" RELATED [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0005295 name: neutral amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005282 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "sodium/neutral amino acid transporter" BROAD [] is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0005297 name: proline:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] synonym: "hydrogen/proline transporter" BROAD [] is_a: GO:0005280 ! amino acid:proton symporter activity [Term] id: GO:0005298 name: proline:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] synonym: "sodium/proline symporter activity" EXACT [] xref: Reactome:R-HSA-444100 "PROT mediates L-proline uptake" xref: RHEA:28967 is_a: GO:0005283 ! amino acid:sodium symporter activity [Term] id: GO:0005300 name: high-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "high-affinity tryptophan transporter activity" BROAD [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0005301 name: obsolete valine/tyrosine/tryptophan permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] synonym: "valine/tyrosine/tryptophan permease activity" EXACT [] is_obsolete: true consider: GO:0005302 consider: GO:0005304 consider: GO:0015196 consider: GO:0022857 [Term] id: GO:0005302 name: L-tyrosine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015508 def: "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-tyrosine permease activity" EXACT [] synonym: "L-tyrosine transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015828 ! tyrosine transport [Term] id: GO:0005304 name: L-valine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-valine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity relationship: part_of GO:1903785 ! L-valine transmembrane transport [Term] id: GO:0005307 name: choline:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015220 ! choline transmembrane transporter activity [Term] id: GO:0005308 name: creatine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0015881 ! creatine transmembrane transport [Term] id: GO:0005309 name: creatine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] xref: Reactome:R-HSA-200396 "Creatine transport across the plasma membrane" is_a: GO:0005308 ! creatine transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" xref: Reactome:R-HSA-372843 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0005311 name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" EXACT [] is_obsolete: true consider: GO:0005310 consider: GO:0005343 consider: GO:0015142 [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015813 ! L-glutamate transmembrane transport [Term] id: GO:0005314 name: high-affinity glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transporter activity" BROAD [] xref: Reactome:R-HSA-210404 "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+" xref: Reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5625015 "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5625029 "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015501 ! glutamate:sodium symporter activity [Term] id: GO:0005315 name: inorganic phosphate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005317 def: "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0005316 name: high-affinity inorganic phosphate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2] synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT [] synonym: "sodium/phosphate cotransporter activity" BROAD [] is_a: GO:0005436 ! sodium:phosphate symporter activity [Term] id: GO:0005318 name: obsolete phosphate:hydrogen symporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] synonym: "phosphate:hydrogen symporter" EXACT [] synonym: "phosphate:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015317 [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: MIPS_funcat:20.01.13 xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0006869 ! lipid transport [Term] id: GO:0005320 name: obsolete apolipoprotein namespace: molecular_function alt_id: GO:0015907 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "apolipoprotein" EXACT [] is_obsolete: true consider: GO:0005319 [Term] id: GO:0005321 name: obsolete high-density lipoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "HDL" EXACT [] synonym: "high-density lipoprotein" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005322 name: obsolete low-density lipoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "LDL" EXACT [] synonym: "low-density lipoprotein" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005323 name: obsolete very-low-density lipoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "very-low-density lipoprotein" EXACT [] synonym: "VLDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005324 name: long-chain fatty acid transporter activity namespace: molecular_function alt_id: GO:0005325 alt_id: GO:0008562 def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [ISBN:0198506732] {comment="EC:7.6.2.4"} synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:7.6.2.4] synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] synonym: "peroxisomal fatty acyl CoA transporter activity" NARROW [] synonym: "peroxisomal fatty-acyl-CoA transmembrane transporter activity" NARROW [] synonym: "peroxisomal fatty-acyl-CoA transporter activity" NARROW [] synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] xref: EC:7.6.2.4 xref: Reactome:R-HSA-2046087 "Translocation of tetracosahexaenoyl-CoA to peroxisomes" xref: Reactome:R-HSA-2046093 "Translocation of tetracosapentaenoyl-CoA to peroxisomes" xref: Reactome:R-HSA-382575 "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix" xref: Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA" xref: Reactome:R-HSA-434381 "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol" xref: Reactome:R-HSA-5684043 "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix" xref: RHEA:15181 is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0015909 ! long-chain fatty acid transport [Term] id: GO:0005326 name: neurotransmitter transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah] synonym: "neurotransmitter transporter activity" RELATED [] xref: MIPS_funcat:20.01.26 xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0006836 ! neurotransmitter transport [Term] id: GO:0005328 name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] synonym: "sodium/neurotransmitter symporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005330 name: dopamine:sodium symporter activity namespace: molecular_function alt_id: GO:0005329 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.3] comment: Merge terms, see https://github.com/geneontology/go-ontology/issues/16054 synonym: "dopamine transmembrane transporter activity" EXACT [] synonym: "dopamine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/dopamine symporter activity" EXACT [] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0090494 ! dopamine uptake [Term] id: GO:0005332 name: gamma-aminobutyric acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" EXACT [] synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] xref: Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport" is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0005334 name: norepinephrine:sodium symporter activity namespace: molecular_function alt_id: GO:0005333 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.2] synonym: "levarterenol transporter activity" EXACT [] synonym: "noradrenaline transporter activity" EXACT [] synonym: "norepinephrine transmembrane transporter activity" EXACT [] synonym: "norepinephrine:sodium symporter activity" EXACT [] synonym: "norepinephrine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter activity" EXACT [] xref: Reactome:R-HSA-443997 "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659764 "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol" xref: Wikipedia:Norepinephrine_transporter is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0051620 ! norepinephrine uptake [Term] id: GO:0005335 name: serotonin:sodium symporter activity namespace: molecular_function alt_id: GO:0005336 alt_id: GO:0015222 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.1] synonym: "serotonin transmembrane transporter activity" EXACT [] synonym: "serotonin:sodium:chloride symporter activity" EXACT [] synonym: "sodium/serotonin symporter activity" EXACT [] xref: Reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol" is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0051610 ! serotonin uptake [Term] id: GO:0005337 name: nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] xref: MIPS_funcat:20.01.19 xref: Reactome:R-HSA-109527 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" xref: Reactome:R-HSA-109529 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" xref: Reactome:R-HSA-109534 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" xref: Reactome:R-HSA-109536 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" xref: Reactome:R-HSA-5628807 "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol" xref: Reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" xref: Reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol" xref: Reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen" xref: Reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:1901642 ! nucleoside transmembrane transport [Term] id: GO:0005338 name: nucleotide-sugar transmembrane transporter activity namespace: molecular_function alt_id: GO:0005339 def: "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] xref: Reactome:R-HSA-744230 "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP" xref: Reactome:R-HSA-744231 "SLC35D2 exchanges UDP-sugars for UMP" is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0005340 name: nucleotide-sulfate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005341 def: "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] synonym: "nucleotide-sulphate transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage," [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1903825 ! organic acid transmembrane transport [Term] id: GO:0005343 name: organic acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:R-HSA-8876312 "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005344 name: oxygen carrier activity namespace: molecular_function alt_id: GO:0015033 def: "Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai] synonym: "globin" NARROW [] synonym: "hemerythrin" NARROW [] synonym: "hemocyanin" NARROW [] synonym: "oxygen-carrying" NARROW [] is_a: GO:0005215 ! transporter activity relationship: part_of GO:0015671 ! oxygen transport [Term] id: GO:0005345 name: purine nucleobase transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732] synonym: "purine base transmembrane transporter activity" EXACT [GOC:go_curators] synonym: "purine transmembrane transporter activity" RELATED [] is_a: GO:0015205 ! nucleobase transmembrane transporter activity relationship: part_of GO:1904823 ! purine nucleobase transmembrane transport [Term] id: GO:0005346 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0005347 name: ATP transmembrane transporter activity namespace: molecular_function alt_id: GO:0005348 def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity relationship: part_of GO:0015867 ! ATP transport [Term] id: GO:0005350 name: pyrimidine nucleobase transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai] synonym: "pyrimidine base transmembrane transporter activity" EXACT [GOC:go_curators] synonym: "pyrimidine transmembrane transporter activity" RELATED [] is_a: GO:0015205 ! nucleobase transmembrane transporter activity relationship: part_of GO:0015855 ! pyrimidine nucleobase transport relationship: part_of GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0005351 name: carbohydrate:proton symporter activity namespace: molecular_function alt_id: GO:0005403 alt_id: GO:0015542 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] synonym: "cation/sugar symporter activity" BROAD [] synonym: "hydrogen:sugar symporter activity" EXACT [] synonym: "hydrogen:sugar transporter activity" BROAD [] synonym: "lactose/glucose efflux transporter activity" NARROW [] synonym: "proton:sugar symporter activity" EXACT [] synonym: "sugar efflux transmembrane transporter activity" BROAD [PMID:20971900] synonym: "sugar porter activity" RELATED [] synonym: "sugar transporter" BROAD [] synonym: "sugar:hydrogen ion symporter activity" EXACT [] synonym: "sugar:hydrogen symporter activity" EXACT [] synonym: "sugar:proton symporter activity" NARROW [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005352 name: alpha-glucoside:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] synonym: "alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005353 name: fructose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015585 alt_id: GO:0019192 def: "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "fructose permease activity" EXACT [] synonym: "fructose porter activity" EXACT [] xref: Reactome:R-HSA-189222 "SLC2A5 transports fructose from extracellular region to cytosol" is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015755 ! fructose transmembrane transport [Term] id: GO:0005354 name: galactose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015757 ! galactose transmembrane transport [Term] id: GO:0005355 name: glucose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015579 def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "glucose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:1904659 ! glucose transmembrane transport [Term] id: GO:0005356 name: glucose:proton symporter activity namespace: molecular_function alt_id: GO:0005361 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "hydrogen:glucose symporter activity" EXACT [] synonym: "hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen:glucose symporter activity" NARROW [] synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0009679 ! hexose:proton symporter activity [Term] id: GO:0005357 name: obsolete constitutive glucose:proton symporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] comment: The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter. synonym: "constitutive hydrogen/glucose transporter activity" BROAD [] synonym: "constitutive hydrogen:glucose symporter activity" EXACT [] synonym: "constitutive hydrogen:glucose transporter activity" BROAD [] is_obsolete: true [Term] id: GO:0005358 name: high-affinity glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "high-affinity hydrogen:glucose symporter activity" EXACT [] synonym: "high-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005359 name: low-affinity glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "low-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "low-affinity hydrogen:glucose symporter activity" EXACT [] synonym: "low-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005360 name: insulin-responsive glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "insulin-responsive hydrogen:glucose symporter activity" EXACT [] synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005362 name: low-affinity glucose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] xref: Reactome:R-HSA-429567 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4" is_a: GO:0005412 ! glucose:sodium symporter activity [Term] id: GO:0005363 name: maltose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015581 def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "maltose porter activity" EXACT [] xref: RHEA:33171 is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015768 ! maltose transport [Term] id: GO:0005364 name: maltose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] synonym: "hydrogen/maltose transporter activity" BROAD [] synonym: "maltose permease" BROAD [] synonym: "maltose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0005363 ! maltose transmembrane transporter activity [Term] id: GO:0005365 name: myo-inositol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] synonym: "vitamin Bh transporter activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015798 ! myo-inositol transport [Term] id: GO:0005366 name: myo-inositol:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005367 name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter activity" BROAD [] xref: Reactome:R-HSA-429663 "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005368 name: taurine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] xref: RHEA:14613 is_a: GO:0042959 ! alkanesulfonate transmembrane transporter activity relationship: part_of GO:0015734 ! taurine transport [Term] id: GO:0005369 name: taurine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005368 ! taurine transmembrane transporter activity [Term] id: GO:0005371 name: tricarboxylate secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0005370 def: "Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0815340729] synonym: "tricarboxylate carrier activity" EXACT [] is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0005372 name: water transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of water (H2O) from one side of a membrane to the other." [GOC:ai] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0006833 ! water transport [Term] id: GO:0005373 name: obsolete heavy metal ion porter activity namespace: molecular_function def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "heavy metal ion porter activity" EXACT [] synonym: "metal ion transporter" BROAD [] is_obsolete: true consider: GO:0015291 consider: GO:0046873 [Term] id: GO:0005375 name: copper ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005378 alt_id: GO:0005379 alt_id: GO:0005380 alt_id: GO:0015088 def: "Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] synonym: "copper uptake transmembrane transporter activity" RELATED [] synonym: "intracellular copper ion transporter" NARROW [] synonym: "plasma membrane copper transporter" NARROW [] xref: Reactome:R-HSA-437300 "SLC31A1 transports Cu2+ from extracellular region to cytosol" xref: RHEA:28703 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0005376 name: obsolete plasma membrane copper transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "plasma membrane copper transporter" EXACT [] is_obsolete: true consider: GO:0005375 consider: GO:0005886 [Term] id: GO:0005377 name: obsolete intracellular copper ion transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "intracellular copper ion transporter" EXACT [] synonym: "intracellular copper transporter" EXACT [] is_obsolete: true consider: GO:0005375 consider: GO:0005622 [Term] id: GO:0005381 name: iron ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005382 alt_id: GO:0016033 alt_id: GO:0097689 def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell. Merged terms, see https://github.com/geneontology/go-ontology/issues/17162. synonym: "iron cation channel activity" EXACT [] synonym: "iron channel activity" EXACT [] synonym: "iron transporter activity" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: Reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0005384 name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf] xref: Reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0071421 ! manganese ion transmembrane transport [Term] id: GO:0005385 name: zinc ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf] synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] synonym: "zinc, iron permease activity" NARROW [] xref: Reactome:R-HSA-435366 "ZnT1 mediates the efflux of zinc from the cell" xref: Reactome:R-HSA-435375 "ZnT2 facilitates zinc vesicular sequestration" xref: Reactome:R-HSA-437084 "ZnT3 transports zinc into synaptic vesicles" xref: Reactome:R-HSA-437085 "ZnT5 transports zinc into secretory granules in pancreatic beta cells" xref: Reactome:R-HSA-437129 "ZnT7 transports zinc into the golgi apparatus" xref: Reactome:R-HSA-437136 "SLC30A8 transports Zn2+ from cytosol to secretory granule" xref: Reactome:R-HSA-437139 "ZnT6 transports zinc into the golgi apparatus" xref: Reactome:R-HSA-442317 "ZIP6 and ZIP14 mediate zinc influx into cells" xref: Reactome:R-HSA-442345 "hZIP10 mediates zinc influx into cells" xref: Reactome:R-HSA-442387 "ZIP8 mediates zinc influx into cells" xref: Reactome:R-HSA-442393 "ZIP7 mediates zinc efflux from the endoplasmic reticulum" xref: Reactome:R-HSA-442405 "hZIP5 mediates zinc uptake by cells" xref: Reactome:R-HSA-442422 "SLC39A1-4 transports Zn2+ from extracellular region to cytosol" xref: Reactome:R-HSA-5654125 "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol" xref: RHEA:29351 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity relationship: part_of GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0005388 name: calcium transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:7.2.2.10] synonym: "ATP-dependent calcium transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled calcium transmembrane transporter activity" RELATED [] synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:7.2.2.10] synonym: "Ca2+-transporting ATPase activity" EXACT [EC:7.2.2.10] synonym: "calcium efflux ATPase" NARROW [] synonym: "calcium pump" BROAD [] synonym: "calcium transporting ATPase activity" EXACT [] synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:7.2.2.10] synonym: "calcium-transporting ATPase activity" EXACT [] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [] xref: EC:7.2.2.10 xref: MetaCyc:3.6.3.8-RXN xref: Reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region" xref: Reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen" xref: Reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen" xref: Reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" xref: RHEA:18105 is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0005391 name: sodium:potassium-exchanging ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:7.2.2.13] synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:7.2.2.13] synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:7.2.2.13] synonym: "Na+,K+-ATPase activity" EXACT [EC:7.2.2.13] synonym: "Na+/K+-ATPase activity" EXACT [EC:7.2.2.13] synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:7.2.2.13] synonym: "Na,K-activated ATPase activity" EXACT [EC:7.2.2.13] synonym: "P-type sodium:potassium-exchanging ATPase activity" RELATED [Wikipedia:ATPase\,_Na%2B/K%2B_transporting\,_alpha_1] synonym: "sodium pump" BROAD [EC:7.2.2.13] synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] synonym: "sodium/potassium-transporting ATPase activity" EXACT [] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:7.2.2.13 xref: MetaCyc:3.6.3.9-RXN xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges Na+ for K+" xref: RHEA:18353 is_a: GO:0008554 ! sodium transmembrane transporter activity, phosphorylative mechanism is_a: GO:0008556 ! potassium transmembrane transporter activity, phosphorylative mechanism relationship: part_of GO:0010248 ! establishment or maintenance of transmembrane electrochemical gradient [Term] id: GO:0005395 name: obsolete eye pigment precursor transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions. xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport" xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol" xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes" is_obsolete: true [Term] id: GO:0005396 name: obsolete transmembrane conductance regulator activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. synonym: "transmembrane conductance regulator activity" EXACT [] is_obsolete: true consider: GO:0043267 [Term] id: GO:0005400 name: obsolete peroxisomal membrane transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "peroxisomal membrane transporter" EXACT [] is_obsolete: true consider: GO:0005215 consider: GO:0005777 [Term] id: GO:0005402 name: carbohydrate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] synonym: "cation/sugar symporter activity" EXACT [] synonym: "cation:sugar symporter activity" EXACT [] synonym: "sugar:cation symporter activity" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005412 name: glucose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] synonym: "sodium/glucose symporter activity" EXACT [] xref: Reactome:R-HSA-189208 "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol" xref: Reactome:R-HSA-429613 "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5656356 "Defective SLC5A1 does not cotransport Glc and Na+" xref: Reactome:R-HSA-5658163 "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-8932955 "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol" is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005415 name: nucleoside:sodium symporter activity namespace: molecular_function alt_id: GO:0008522 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] synonym: "nucleoside-sodium cotransporter activity" BROAD [] synonym: "sodium-dependent nucleoside transporter activity" BROAD [] xref: Reactome:R-HSA-109530 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1" xref: Reactome:R-HSA-109538 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3" xref: Reactome:R-HSA-109539 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2" is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005416 name: amino acid:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] synonym: "cation/amino acid symporter activity" EXACT [] synonym: "cation:amino acid symporter activity" EXACT [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005427 name: proton-dependent oligopeptide secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] synonym: "hydrogen/oligopeptide symporter" RELATED [] synonym: "proton-dependent oligopeptide transporter activity" EXACT [] is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity [Term] id: GO:0005429 name: obsolete chromaffin granule amine transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of amines across chromaffin granule membranes." [GOC:mah] comment: The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion. is_obsolete: true [Term] id: GO:0005430 name: obsolete synaptic vesicle amine transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes." [GOC:ai] comment: The class was obsoleted because the cellular location of a function should not be part of the class label. is_obsolete: true consider: GO:0005275 [Term] id: GO:0005432 name: calcium:sodium antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] synonym: "sodium/calcium exchanger" EXACT [] synonym: "sodium:calcium exchange" RELATED [] xref: Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+" xref: Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" xref: Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity [Term] id: GO:0005436 name: sodium:phosphate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] synonym: "sodium/phosphate symporter activity" EXACT [] xref: Reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol" is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005451 name: monovalent cation:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] synonym: "monovalent cation:hydrogen antiporter activity" EXACT [] xref: Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+, Li+ for H+" is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005452 name: inorganic anion exchanger activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] xref: Reactome:R-HSA-1237038 "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-" xref: Reactome:R-HSA-1247665 "Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate" xref: Reactome:R-HSA-425482 "SLC4A1,2,3 exchanges HCO3- for Cl-" xref: Reactome:R-HSA-425577 "Na+-driven Cl-/HCO3- exchanger transport" xref: Reactome:R-HSA-427666 "SLC26A3,6 exchange Cl- for HCO3-" xref: Reactome:R-HSA-5627737 "SLC26A3 does not exchange Cl- for HCO3-" xref: Reactome:R-HSA-5656248 "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes)" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0005456 name: CMP-N-acetylneuraminate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "CMP-sialic acid transmembrane transporter activity" BROAD [] xref: Reactome:R-HSA-5651942 "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP" xref: Reactome:R-HSA-727807 "SLC35A1 exchanges CMP-Neu5Ac for CMP" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015782 ! CMP-N-acetylneuraminate transmembrane transport [Term] id: GO:0005457 name: GDP-fucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-5653596 "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen" xref: Reactome:R-HSA-742345 "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen" is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015783 ! GDP-fucose transmembrane transport [Term] id: GO:0005458 name: GDP-mannose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:1990570 ! GDP-mannose transmembrane transport [Term] id: GO:0005459 name: UDP-galactose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-5652099 "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP" xref: Reactome:R-HSA-735702 "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP" is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0072334 ! UDP-galactose transmembrane transport [Term] id: GO:0005460 name: UDP-glucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015786 ! UDP-glucose transmembrane transport [Term] id: GO:0005461 name: UDP-glucuronic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-174368 "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen" xref: Reactome:R-HSA-5603297 "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc" is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015787 ! UDP-glucuronic acid transmembrane transport [Term] id: GO:0005462 name: UDP-N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-5653622 "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP" xref: Reactome:R-HSA-741450 "SLC35A3 exchanges UDP-GlcNAc for UMP" xref: Reactome:R-HSA-742354 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:1990569 ! UDP-N-acetylglucosamine transmembrane transport [Term] id: GO:0005463 name: UDP-N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015789 ! UDP-N-acetylgalactosamine transmembrane transport [Term] id: GO:0005464 name: UDP-xylose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] xref: Reactome:R-HSA-742373 "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0015790 ! UDP-xylose transmembrane transport [Term] id: GO:0005468 name: obsolete small-molecule carrier or transporter namespace: molecular_function alt_id: GO:0005453 alt_id: GO:0005454 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not provide a useful functional classification. synonym: "small-molecule carrier or transporter" EXACT [] is_obsolete: true consider: GO:0005215 [Term] id: GO:0005469 name: succinate:fumarate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] is_a: GO:0015138 ! fumarate transmembrane transporter activity is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0005471 name: ATP:ADP antiporter activity namespace: molecular_function alt_id: GO:0005349 def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] synonym: "adenine nucleotide translocase" EXACT [] synonym: "ADP/ATP carrier protein" EXACT [] synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] is_a: GO:0005347 ! ATP transmembrane transporter activity is_a: GO:0015217 ! ADP transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0005476 name: carnitine:acyl carnitine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] synonym: "carnitine/acyl carnitine carrier activity" EXACT [] synonym: "carnitine:acyl carnitine carrier activity" EXACT [] synonym: "fatty acyl carnitine carrier" EXACT [] is_a: GO:0015226 ! carnitine transmembrane transporter activity is_a: GO:0015227 ! acyl carnitine transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005477 name: pyruvate secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "pyruvate carrier activity" RELATED [] is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0050833 ! pyruvate transmembrane transporter activity [Term] id: GO:0005479 name: obsolete vacuolar assembly namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vacuolar assembly" EXACT [] is_obsolete: true replaced_by: GO:0007033 [Term] id: GO:0005480 name: obsolete vesicle transport namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle transport" EXACT [] is_obsolete: true replaced_by: GO:0016192 [Term] id: GO:0005481 name: obsolete vesicle fusion namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle fusion" EXACT [] is_obsolete: true consider: GO:0006906 consider: GO:0007086 consider: GO:0016189 consider: GO:0016192 consider: GO:0019817 [Term] id: GO:0005482 name: obsolete vesicle targeting namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle targeting" EXACT [] is_obsolete: true consider: GO:0006903 consider: GO:0016080 [Term] id: GO:0005483 name: soluble NSF attachment protein activity namespace: molecular_function def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] comment: Added parent see https://github.com/geneontology/go-ontology/issues/16807 synonym: "SNAP" EXACT [] is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] subset: goslim_chembl synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0030674 ! protein binding, bridging relationship: part_of GO:0061025 ! membrane fusion [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005489 name: obsolete electron transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] comment: This term was made obsolete because the activity described by the definition does not exist. synonym: "class I cytochrome c" RELATED [] synonym: "class II cytochrome c" RELATED [] synonym: "class IIa cytochrome c" RELATED [] synonym: "class IIb cytochrome c" RELATED [] synonym: "class III cytochrome c" RELATED [] synonym: "class IV cytochrome c" RELATED [] synonym: "cytochrome b" RELATED [] synonym: "cytochrome b5" RELATED [] synonym: "cytochrome c3 (tetraheme)" RELATED [] synonym: "cytochrome c554" RELATED [] synonym: "cytochrome c7 (triheme)" RELATED [] synonym: "cytochrome d" RELATED [] synonym: "diheme class I cytochrome c" RELATED [] synonym: "electron transfer carrier" RELATED [] synonym: "electron transporter activity" EXACT [] synonym: "flavin-containing electron transporter" RELATED [] synonym: "flavodoxin" RELATED [] synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] synonym: "monoheme class I cytochrome c" RELATED [] synonym: "nonaheme cytochrome c" RELATED [] synonym: "respiratory chain cytochrome b6" RELATED [] synonym: "Rieske iron-sulfur protein" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0005490 name: obsolete cytochrome P450 namespace: molecular_function def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] comment: This term was made obsolete because its definition was changed and because it represents a gene product. synonym: "cytochrome P450" EXACT [] is_obsolete: true [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0008289 ! lipid binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0005497 name: androgen binding namespace: molecular_function def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [GOC:jl] is_a: GO:0042562 ! hormone binding [Term] id: GO:0005499 name: vitamin D binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] synonym: "calciferol binding" NARROW [] synonym: "cholecalciferol binding" NARROW [] synonym: "ergocalciferol binding" NARROW [] is_a: GO:0005496 ! steroid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005500 name: juvenile hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005501 name: retinoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] xref: Reactome:R-HSA-2454113 "RBP3 transports 11cRAL to rod photoreceptor outer segment" xref: Reactome:R-HSA-2464809 "RBP3 regulates the transport of atROL from ROS to RPE" xref: Reactome:R-HSA-2465934 "11cROL translocates from Muller cells to cone photoreceptor cells" xref: Reactome:R-HSA-2465938 "RBP3 regulates atROL taken up by Muller cells" is_a: GO:0019840 ! isoprenoid binding [Term] id: GO:0005502 name: 11-cis retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [PMID:24403072] synonym: "11-cis retinaldehyde binding" EXACT [] synonym: "11-cis-retinal binding" NARROW [] synonym: "vitamin A binding" BROAD [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005503 name: all-trans retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [GOC:curators] synonym: "all-trans retinaldehyde binding" EXACT [] synonym: "trans retinal binding" EXACT [] synonym: "visual yellow binding" EXACT [] synonym: "vitamin A binding" BROAD [] synonym: "xanthopsin" RELATED [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] xref: MIPS_funcat:16.13.03 is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0005505 name: obsolete heavy metal binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal binding" EXACT [] is_obsolete: true consider: GO:0046872 [Term] id: GO:0005506 name: iron ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] synonym: "iron binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005507 name: copper ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] synonym: "copper binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005508 name: obsolete copper/cadmium binding namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a composite function. synonym: "copper/cadmium binding" EXACT [] is_obsolete: true consider: GO:0005507 consider: GO:0046870 [Term] id: GO:0005509 name: calcium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] synonym: "calcium ion storage activity" RELATED [] xref: MIPS_funcat:16.17.01 is_a: GO:0046872 ! metal ion binding [Term] id: GO:0005513 name: detection of calcium ion namespace: biological_process def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "Ca2+ ion detection" EXACT [] synonym: "calcium ion detection" EXACT [] synonym: "calcium ion sensing" EXACT [] synonym: "detection of Ca2+ ion" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051592 ! response to calcium ion [Term] id: GO:0005514 name: obsolete calcium ion storage activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "calcium ion storage activity" EXACT [] is_obsolete: true consider: GO:0005509 consider: GO:0051208 [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: MIPS_funcat:16.01 xref: MIPS_funcat:18.01.07 xref: Reactome:R-HSA-170835 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3" xref: Reactome:R-HSA-170846 "TGFBR2 recruits TGFBR1" is_a: GO:0005488 ! binding [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0005517 name: obsolete calmodulin inhibitor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'. synonym: "calmodulin inhibitor activity" EXACT [] is_obsolete: true consider: GO:0005516 [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005519 name: cytoskeletal regulatory protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732] subset: goslim_chembl synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005521 name: lamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732] synonym: "lamin/chromatin binding" BROAD [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005522 name: profilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] is_a: GO:0005515 ! protein binding [Term] id: GO:0005523 name: tropomyosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] xref: MIPS_funcat:16.19.03 xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel" is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005525 name: GTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] xref: MIPS_funcat:16.19.05 xref: Reactome:R-HSA-167429 "The receptor:G-protein complex binds GTP" is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005527 name: macrolide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0005528 name: FK506 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] is_a: GO:0005527 ! macrolide binding [Term] id: GO:0005530 name: obsolete lectin namespace: molecular_function def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators] comment: This term was made obsolete because it refers to a class of gene products. synonym: "lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0030246 [Term] id: GO:0005531 name: obsolete galactose binding lectin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "galactose binding lectin" EXACT [] is_obsolete: true consider: GO:0005534 consider: GO:0007157 [Term] id: GO:0005532 name: obsolete mannose binding lectin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mannose binding lectin" EXACT [] synonym: "mannose receptor" RELATED [] is_obsolete: true consider: GO:0005537 consider: GO:0007157 [Term] id: GO:0005533 name: obsolete N-acetylgalactosamine lectin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "N-acetylgalactosamine lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0046871 [Term] id: GO:0005534 name: galactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [GOC:jl, ISBN:0198506732] synonym: "galactose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005536 name: glucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [GOC:jl] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981] subset: goslim_chembl synonym: "mannose binding lectin" RELATED [] xref: Reactome:R-HSA-947991 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi" is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0005541 name: obsolete acyl-CoA or acyl binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was replaced by more appropriate terms. synonym: "acyl-CoA or acyl binding" EXACT [] is_obsolete: true consider: GO:0000035 consider: GO:0000062 [Term] id: GO:0005542 name: folic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732] synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0033218 ! amide binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0005543 name: phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding is_a: GO:0043168 ! anion binding [Term] id: GO:0005544 name: calcium-dependent phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0005545 name: 1-phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0005546 name: phosphatidylinositol-4,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT [] synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc] synonym: "PIP2 binding" BROAD [] synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf] is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding [Term] id: GO:0005547 name: phosphatidylinositol-3,4,5-trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "PIP3 binding" EXACT [GOC:bf] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0005548 name: phospholipid transporter activity namespace: molecular_function alt_id: GO:0008497 def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732] xref: Reactome:R-HSA-216757 "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane" xref: Reactome:R-HSA-382553 "ABCA7:Apo1A-mediated phospholipid efflux" xref: Reactome:R-HSA-5678706 "ABCB4 transports PC from plasma membrane to extracellular region" xref: Reactome:R-HSA-5678749 "Defective ABCB4 does not transport PC from plasma membrane to extracellular region" xref: Reactome:R-HSA-8857662 "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane" xref: Reactome:R-HSA-8865637 "MFSD2A transports LPC from extracellular region to plasma membrane" xref: Reactome:R-HSA-8867876 "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0015914 ! phospholipid transport [Term] id: GO:0005549 name: odorant binding namespace: molecular_function def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0005550 name: pheromone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] is_a: GO:0005549 ! odorant binding [Term] id: GO:0005551 name: obsolete ubiquitin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0016567 consider: GO:0031386 [Term] id: GO:0005552 name: obsolete polyubiquitin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "polyubiquitin" EXACT [] is_obsolete: true consider: GO:0000209 [Term] id: GO:0005553 name: obsolete ubiquitin-ribosomal protein fusion protein namespace: molecular_function def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732] comment: This term was made obsolete because it describes a gene product. synonym: "ubiquitin-ribosomal protein fusion protein" EXACT [] is_obsolete: true [Term] id: GO:0005555 name: obsolete blood group antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "blood group antigen" EXACT [] is_obsolete: true [Term] id: GO:0005557 name: obsolete lymphocyte antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "lymphocyte antigen" EXACT [] is_obsolete: true [Term] id: GO:0005558 name: obsolete minor histocompatibility antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "minor histocompatibility antigen" EXACT [] is_obsolete: true [Term] id: GO:0005559 name: obsolete ribozyme namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "ribozyme" EXACT [] is_obsolete: true [Term] id: GO:0005561 name: obsolete nucleic acid namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "nucleic acid" EXACT [] is_obsolete: true [Term] id: GO:0005562 name: obsolete RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "RNA" EXACT [] is_obsolete: true [Term] id: GO:0005563 name: obsolete transfer RNA namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "transfer RNA" EXACT [] is_obsolete: true replaced_by: GO:0030533 [Term] id: GO:0005564 name: obsolete cytosolic tRNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "cytosolic tRNA" EXACT [] is_obsolete: true [Term] id: GO:0005565 name: obsolete mitochondrial tRNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "mitochondrial tRNA" EXACT [] is_obsolete: true [Term] id: GO:0005566 name: obsolete ribosomal RNA namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "ribosomal RNA" EXACT [] is_obsolete: true consider: GO:0003735 consider: GO:0005840 [Term] id: GO:0005567 name: obsolete cytosolic ribosomal RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "cytosolic ribosomal RNA" EXACT [] is_obsolete: true [Term] id: GO:0005568 name: obsolete mitochondrial rRNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "mitochondrial rRNA" EXACT [] is_obsolete: true [Term] id: GO:0005569 name: obsolete small nucleolar RNA namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. synonym: "small nucleolar RNA" EXACT [] is_obsolete: true consider: GO:0030555 [Term] id: GO:0005570 name: obsolete small nuclear RNA namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. synonym: "small nuclear RNA" EXACT [] is_obsolete: true consider: GO:0000375 consider: GO:0017069 [Term] id: GO:0005571 name: obsolete untranslated RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "untranslated RNA" EXACT [] is_obsolete: true [Term] id: GO:0005572 name: obsolete RNA polymerase II transcribed untranslated RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "RNA polymerase II transcribed untranslated RNA" EXACT [] is_obsolete: true [Term] id: GO:0005573 name: obsolete telomerase RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a gene product. synonym: "telomerase RNA" EXACT [] is_obsolete: true replaced_by: GO:0000332 [Term] id: GO:0005574 name: obsolete DNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "DNA" EXACT [] is_obsolete: true [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "extracellular" EXACT [] xref: MIPS_funcat:70.27 xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005579 name: membrane attack complex namespace: cellular_component def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149] synonym: "MAC" EXACT [] synonym: "membrane attack complex protein alphaM chain" NARROW [] synonym: "membrane attack complex protein beta2 chain" NARROW [] synonym: "TCC" EXACT [] synonym: "terminal complement complex" EXACT [] xref: Wikipedia:Complement_membrane_attack_complex is_a: GO:0046930 ! pore complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005580 name: obsolete membrane attack complex protein alphaM chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "membrane attack complex protein alphaM chain" EXACT [] is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0005581 name: collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0005582 name: collagen type XV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911] is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005583 name: fibrillar collagen trimer namespace: cellular_component def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098643 ! banded collagen fibril disjoint_from: GO:0005598 ! short-chain collagen trimer disjoint_from: GO:0030936 ! transmembrane collagen trimer relationship: part_of GO:0098643 ! banded collagen fibril [Term] id: GO:0005584 name: collagen type I trimer namespace: cellular_component def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976] xref: Wikipedia:Collagen_type_I is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005585 name: collagen type II trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005586 name: collagen type III trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005588 name: collagen type V trimer namespace: cellular_component def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005589 name: collagen type VI trimer namespace: cellular_component def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911] is_a: GO:0005581 ! collagen trimer relationship: part_of GO:0098647 ! collagen beaded filament [Term] id: GO:0005590 name: collagen type VII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976, PMID:19693541] is_a: GO:0030934 ! anchoring collagen complex relationship: part_of GO:0098652 ! collagen type VII anchoring fibril [Term] id: GO:0005591 name: collagen type VIII trimer namespace: cellular_component def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911] is_a: GO:0005598 ! short-chain collagen trimer is_a: GO:0030935 ! sheet-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005592 name: collagen type XI trimer namespace: cellular_component def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005593 name: FACIT collagen trimer namespace: cellular_component def: "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911] comment: The acronym FACIT stands for fibril-associated collagen with interrupted triple helix. xref: Wikipedia:FACIT_collagen is_a: GO:0005581 ! collagen trimer [Term] id: GO:0005594 name: collagen type IX trimer namespace: cellular_component def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer [Term] id: GO:0005595 name: collagen type XII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer is_a: GO:0030934 ! anchoring collagen complex [Term] id: GO:0005596 name: collagen type XIV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer is_a: GO:0030934 ! anchoring collagen complex [Term] id: GO:0005597 name: collagen type XVI trimer namespace: cellular_component def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] is_a: GO:0005593 ! FACIT collagen trimer [Term] id: GO:0005598 name: short-chain collagen trimer namespace: cellular_component def: "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer [Term] id: GO:0005599 name: collagen type X trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911] comment: Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541). is_a: GO:0005598 ! short-chain collagen trimer is_a: GO:0030935 ! sheet-forming collagen trimer [Term] id: GO:0005600 name: collagen type XIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bhm, GOC:dos, ISBN:0721639976] is_a: GO:0030936 ! transmembrane collagen trimer [Term] id: GO:0005601 name: classical-complement-pathway C3/C5 convertase complex namespace: cellular_component def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005602 name: complement component C1 complex namespace: cellular_component def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149] synonym: "complement component C1q complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0062167 ! complement component C1q complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005603 name: obsolete complement component C2 complex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex". synonym: "complement component C2 complex" EXACT [] is_obsolete: true [Term] id: GO:0005604 name: basement membrane namespace: cellular_component alt_id: GO:0005605 alt_id: GO:0008003 def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. synonym: "basal lamina" RELATED [] synonym: "basement lamina" RELATED [] synonym: "lamina densa" RELATED [] xref: Wikipedia:Basement_membrane is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005606 name: laminin-1 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-111 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005607 name: laminin-2 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-211 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005608 name: laminin-3 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] synonym: "laminin-121 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005609 name: laminin-4 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-221 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005610 name: laminin-5 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-332 complex" NARROW [GOC:dph, PMID:15979864] synonym: "laminin-3A32 complex" EXACT [PMID:15979864] synonym: "laminin-5A complex" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005611 name: laminin-6 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-311 complex" EXACT [GOC:dph, PMID:15979864] synonym: "laminin-6A complex" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005612 name: laminin-7 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-321 complex" NARROW [GOC:dph, PMID:15979864] synonym: "laminin-7A" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005613 name: obsolete laminin receptor protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. synonym: "laminin receptor protein" EXACT [] is_obsolete: true consider: GO:0008305 [Term] id: GO:0005614 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0005616 name: larval serum protein complex namespace: cellular_component def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005617 name: obsolete larval serum protein-1 namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "larval serum protein-1" EXACT [] synonym: "LSP1" EXACT [] is_obsolete: true [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:42.27.03 xref: MIPS_funcat:70.01 xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0005619 name: ascospore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] synonym: "fungal-type spore wall" BROAD [GOC:mah] is_a: GO:0009277 ! fungal-type cell wall is_a: GO:0031160 ! spore wall [Term] id: GO:0005621 name: cellular bud scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component property_value: IAO:0000589 "cell and encapsulating structures" xsd:string [Term] id: GO:0005624 name: obsolete membrane fraction namespace: cellular_component def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "membrane fraction" EXACT [] is_obsolete: true consider: GO:0016020 [Term] id: GO:0005625 name: obsolete soluble fraction namespace: cellular_component def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "soluble" BROAD [] synonym: "soluble fraction" EXACT [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0005626 name: obsolete insoluble fraction namespace: cellular_component def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "insoluble fraction" EXACT [] synonym: "particle-bound" RELATED [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0005627 name: obsolete ascus namespace: cellular_component def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] comment: This term was made obsolete because it is a structure that contains cell (ascospores) rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. synonym: "ascus" EXACT [] is_obsolete: true [Term] id: GO:0005628 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] synonym: "forespore membrane" RELATED [] synonym: "FSM" EXACT [] is_a: GO:0016020 ! membrane relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0005630 name: dityrosine layer of spore wall namespace: cellular_component def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005631 name: chitosan layer of spore wall namespace: cellular_component def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005632 name: inner layer of spore wall namespace: cellular_component def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005633 name: ascus lipid droplet namespace: cellular_component def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] synonym: "ascus lipid particle" EXACT [] is_a: GO:0005811 ! lipid droplet [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: MIPS_funcat:70.10 xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: MIPS_funcat:70.10.05 xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0005634 ! nucleus relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005637 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627] xref: NIF_Subcellular:sao1612527463 is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031965 ! nuclear membrane [Term] id: GO:0005638 name: lamin filament namespace: cellular_component def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] synonym: "type V intermediate filament" EXACT [] is_a: GO:0005882 ! intermediate filament intersection_of: GO:0005882 ! intermediate filament intersection_of: part_of GO:0005652 ! nuclear lamina relationship: part_of GO:0005652 ! nuclear lamina [Term] id: GO:0005639 name: integral component of nuclear inner membrane namespace: cellular_component def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] synonym: "integral to nuclear inner membrane" NARROW [] is_a: GO:0031229 ! intrinsic component of nuclear inner membrane is_a: GO:0031301 ! integral component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005637 ! nuclear inner membrane [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "outer envelope" BROAD [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005641 name: nuclear envelope lumen namespace: cellular_component alt_id: GO:0005653 def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "nuclear intermembrane space" EXACT [] synonym: "nuclear membrane lumen" RELATED [] synonym: "perinuclear space" EXACT [] is_a: GO:0031970 ! organelle envelope lumen relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005642 name: annulate lamellae namespace: cellular_component def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] is_a: GO:0098589 ! membrane region relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005643 name: nuclear pore namespace: cellular_component alt_id: GO:0005644 def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] synonym: "nucleopore" EXACT [GOC:al, PMID:7603572] xref: NIF_Subcellular:sao220861693 xref: Wikipedia:Nuclear_pore is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005645 name: obsolete RAN-binding protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "RAN-binding protein" EXACT [] is_obsolete: true replaced_by: GO:0008536 consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005646 name: obsolete importin namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin" EXACT [] synonym: "karyopherin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005647 name: obsolete importin, alpha-subunit namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin, alpha-subunit" EXACT [] synonym: "karyopherin-alpha" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005648 name: obsolete importin, beta-subunit namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin, beta-subunit" EXACT [] synonym: "karyopherin-beta1" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005649 name: obsolete transportin namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta2" EXACT [] synonym: "transportin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005650 name: obsolete importin, alpha-subunit transport factor namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "CAS" RELATED [] synonym: "importin, alpha-subunit transport factor" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005651 name: obsolete exportin namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "exportin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005652 name: nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] xref: NIF_Subcellular:sao1455996588 xref: Wikipedia:Nuclear_lamina is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005655 name: nucleolar ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "nucleolar RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex intersection_of: GO:0030677 ! ribonuclease P complex intersection_of: part_of GO:0005730 ! nucleolus relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0005656 name: nuclear pre-replicative complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-RC" RELATED [] synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2] is_a: GO:0036387 ! pre-replicative complex relationship: has_part GO:0000808 ! origin recognition complex relationship: has_part GO:0042555 ! MCM complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0005657 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] synonym: "replication focus" RELATED [] xref: Wikipedia:Replication_fork is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0005658 name: alpha DNA polymerase:primase complex namespace: cellular_component def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] synonym: "DNA polymerase alpha:primase complex" EXACT [] synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] synonym: "pol-prim" RELATED [] synonym: "primosome" BROAD [] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005660 name: obsolete delta-DNA polymerase cofactor complex namespace: cellular_component def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl] comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. synonym: "delta DNA polymerase cofactor complex" EXACT [] synonym: "delta-DNA polymerase cofactor complex" EXACT [] is_obsolete: true consider: GO:0005663 consider: GO:0043626 [Term] id: GO:0005662 name: DNA replication factor A complex namespace: cellular_component def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] xref: Wikipedia:Replication_protein_A is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005663 name: DNA replication factor C complex namespace: cellular_component def: "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520] subset: goslim_pir synonym: "activator 1 complex" EXACT [] synonym: "RFC complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0005664 name: nuclear origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] synonym: "eukaryotic ORC" EXACT [] synonym: "nuclear ORC" EXACT [] is_a: GO:0000808 ! origin recognition complex relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005665 name: RNA polymerase II, core complex namespace: cellular_component def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase II, core complex" EXACT [] synonym: "RNA polymerase II complex" BROAD [] synonym: "RNAP II complex" BROAD [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0016591 ! RNA polymerase II, holoenzyme relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005666 name: RNA polymerase III complex namespace: cellular_component def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase III activity" RELATED [] synonym: "DNA-directed RNA polymerase III complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005667 name: transcription factor complex namespace: cellular_component def: "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005668 name: RNA polymerase transcription factor SL1 complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654] synonym: "selectivity factor SL1 complex" EXACT [GOC:mah] synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0005669 name: transcription factor TFIID complex namespace: cellular_component def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005670 name: obsolete transcription-activating factor, 30kD namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "transcription-activating factor, 30kD" EXACT [] is_obsolete: true replaced_by: GO:0005669 [Term] id: GO:0005671 name: Ada2/Gcn5/Ada3 transcription activator complex namespace: cellular_component alt_id: GO:0002928 def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] comment: In human, this complex is composed of GCN5 or PCAF, ADA2a, ADA3, ZZZ3, ATAC2, SGF29, HCF1, WDR5,YEATS2, NC2-beta, and MBIP. synonym: "Ada Two-A containing complex" EXACT [GOC:rl, PMID:18838386] synonym: "Ada-Two-A-containing complex" EXACT [] synonym: "ATAC complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:1902562 ! H4 histone acetyltransferase complex [Term] id: GO:0005672 name: transcription factor TFIIA complex namespace: cellular_component def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669] is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005673 name: transcription factor TFIIE complex namespace: cellular_component def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462] is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005674 name: transcription factor TFIIF complex namespace: cellular_component def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005675 name: transcription factor TFIIH holo complex namespace: cellular_component def: "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "holo TFIIH complex" EXACT [] is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: has_part GO:0000439 ! transcription factor TFIIH core complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005677 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] is_a: GO:0090568 ! nuclear transcriptional repressor complex [Term] id: GO:0005678 name: obsolete chromatin assembly complex namespace: cellular_component def: "OBSOLETE. Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. synonym: "chromatin assembly complex" EXACT [] synonym: "nucleosome assembly complex" NARROW [] is_obsolete: true consider: GO:0031497 [Term] id: GO:0005680 name: anaphase-promoting complex namespace: cellular_component def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. synonym: "anaphase promoting complex" EXACT [] synonym: "APC" BROAD [] synonym: "cyclosome" EXACT [] xref: Wikipedia:Anaphase-promoting_complex is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0005681 name: spliceosomal complex namespace: cellular_component def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] subset: goslim_pir synonym: "spliceosome" BROAD [] synonym: "spliceosome complex" EXACT [] xref: Wikipedia:Spliceosome is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005682 name: U5 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] synonym: "snRNP U5" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005683 name: U7 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] synonym: "snRNP U7" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005684 name: U2-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005685 name: U1 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah] synonym: "snRNP U1" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005686 name: U2 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself. synonym: "17S U2 snRNP" NARROW [] synonym: "snRNP U2" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005687 name: U4 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah] synonym: "snRNP U4" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005688 name: U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah] synonym: "snRNP U6" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex relationship: has_part GO:0120115 ! Lsm2-8 complex [Term] id: GO:0005689 name: U12-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah] synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah] xref: Wikipedia:Minor_spliceosome is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005690 name: U4atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah] synonym: "snRNP U4atac" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005691 name: U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah] synonym: "snRNP U6atac" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005692 name: U11 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah] synonym: "12S U11 snRNP" NARROW [] synonym: "snRNP U11" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005693 name: U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah] synonym: "snRNP U12" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: MIPS_funcat:70.10.03 xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005695 name: obsolete chromatid namespace: cellular_component def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732] comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. synonym: "chromatid" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 consider: GO:0005694 [Term] id: GO:0005696 name: obsolete telomere namespace: cellular_component def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055] comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. synonym: "telomere" EXACT [] is_obsolete: true consider: GO:0000781 consider: GO:0000782 [Term] id: GO:0005697 name: telomerase holoenzyme complex namespace: cellular_component def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] subset: goslim_pir is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005698 name: obsolete centromere namespace: cellular_component def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732] comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization. synonym: "centromere" EXACT [] is_obsolete: true consider: GO:0000775 [Term] id: GO:0005700 name: polytene chromosome namespace: cellular_component def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] xref: Wikipedia:Polytene_chromosome is_a: GO:0005694 ! chromosome [Term] id: GO:0005701 name: polytene chromosome chromocenter namespace: cellular_component def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome chromocentre" EXACT [] is_a: GO:0010369 ! chromocenter intersection_of: GO:0010369 ! chromocenter intersection_of: part_of GO:0005700 ! polytene chromosome relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005702 name: polytene chromosome weak point namespace: cellular_component def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] synonym: "constriction" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005703 name: polytene chromosome puff namespace: cellular_component def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005704 name: polytene chromosome band namespace: cellular_component def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005705 name: polytene chromosome interband namespace: cellular_component def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005706 name: polytene chromosome ectopic fiber namespace: cellular_component def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome ectopic fibre" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005707 name: obsolete interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "interphase chromosome" EXACT [] is_obsolete: true consider: GO:0005694 [Term] id: GO:0005708 name: obsolete mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. synonym: "mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005709 name: obsolete prophase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "prophase chromosome" EXACT [] is_obsolete: true consider: GO:0005694 [Term] id: GO:0005710 name: obsolete metaphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "metaphase chromosome" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005711 name: obsolete meiotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. synonym: "meiotic chromosome" EXACT [] is_obsolete: true consider: GO:0000794 [Term] id: GO:0005712 name: chiasma namespace: cellular_component def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732] xref: Wikipedia:Chiasma_(genetics) is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005713 name: recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005714 name: early recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005715 name: late recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005719 name: nuclear euchromatin namespace: cellular_component def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000791 ! euchromatin intersection_of: GO:0000791 ! euchromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005720 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005721 name: pericentric heterochromatin namespace: cellular_component def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] synonym: "centric heterochromatin" EXACT [] synonym: "centromeric heterochromatin" EXACT [GOC:dph] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0005722 name: beta-heterochromatin namespace: cellular_component def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] is_a: GO:0005721 ! pericentric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005723 name: alpha-heterochromatin namespace: cellular_component def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] is_a: GO:0005721 ! pericentric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005724 name: nuclear telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0031933 ! telomeric heterochromatin intersection_of: GO:0031933 ! telomeric heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0005725 name: intercalary heterochromatin namespace: cellular_component def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] is_a: GO:0005720 ! nuclear heterochromatin [Term] id: GO:0005726 name: perichromatin fibrils namespace: cellular_component def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0005727 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: goslim_metagenomics is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0046821 ! extrachromosomal DNA [Term] id: GO:0005728 name: extrachromosomal rDNA circle namespace: cellular_component def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] synonym: "extrachromosomal ribosomal DNA circle" EXACT [] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005729 name: 2-micrometer circle DNA namespace: cellular_component def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:70.10.07 xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005731 name: nucleolus organizer region namespace: cellular_component def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] synonym: "NOR" EXACT [] synonym: "nucleolus organiser region" EXACT [] synonym: "nucleolus organizer complex" RELATED [] xref: Wikipedia:Nucleolus_organizer_region is_a: GO:0030874 ! nucleolar chromatin [Term] id: GO:0005732 name: small nucleolar ribonucleoprotein complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] comment: Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex. subset: goslim_pir synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005733 name: obsolete small nucleolar RNA namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "small nucleolar RNA" EXACT [] synonym: "snoRNA" EXACT [] is_obsolete: true [Term] id: GO:0005734 name: obsolete box C + D snoRNP protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "box C + D snoRNP protein" EXACT [] is_obsolete: true [Term] id: GO:0005735 name: obsolete box H + ACA snoRNP protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "box H + ACA snoRNP protein" EXACT [] is_obsolete: true [Term] id: GO:0005736 name: RNA polymerase I complex namespace: cellular_component def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase I activity" RELATED [] synonym: "DNA-directed RNA polymerase I complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:70.03 xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: MIPS_funcat:70.16 xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "outer mitochondrial membrane" EXACT [] xref: MIPS_funcat:70.16.01 xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane [Term] id: GO:0005742 name: mitochondrial outer membrane translocase complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] synonym: "GIP complex" NARROW [PMID:23201437] synonym: "TOM complex" EXACT [PMID:23201437] is_a: GO:0098799 ! outer mitochondrial membrane protein complex [Term] id: GO:0005743 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] synonym: "inner mitochondrial membrane" EXACT [] xref: MIPS_funcat:70.16.05 xref: NIF_Subcellular:sao1371347282 xref: Wikipedia:Inner_mitochondrial_membrane is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031966 ! mitochondrial membrane [Term] id: GO:0005744 name: TIM23 mitochondrial import inner membrane translocase complex namespace: cellular_component def: "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:7.4.2.3, PMID:27554484, PMID:8851659] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. subset: goslim_pir synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane presequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane translocase complex" BROAD [] synonym: "Tim23 complex" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0005745 name: m-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776] is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:1905368 ! peptidase complex relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane [Term] id: GO:0005746 name: mitochondrial respirasome namespace: cellular_component alt_id: GO:0097249 def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] comment: Merged and changed label as requested\nhttps://github.com/geneontology/go-ontology/issues/12846 synonym: "mitochondrial electron transport chain" EXACT [] synonym: "mitochondrial respirasome" RELATED [] synonym: "mitochondrial respiratory chain" EXACT [] synonym: "mitochondrial respiratory chain supercomplex" EXACT [] synonym: "mitochondrial respiratory supercomplex" EXACT [] is_a: GO:0070469 ! respirasome intersection_of: GO:0070469 ! respirasome intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane created_by: paola creation_date: 2012-02-23T05:13:54Z [Term] id: GO:0005747 name: mitochondrial respiratory chain complex I namespace: cellular_component alt_id: GO:0005748 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045271 ! respiratory chain complex I is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045271 ! respiratory chain complex I intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005749 name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) namespace: cellular_component alt_id: GO:0008136 alt_id: GO:0009362 alt_id: GO:0019738 alt_id: GO:0030390 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684] synonym: "mitochondrial fumarate reductase complex" EXACT [] is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045283 ! fumarate reductase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045283 ! fumarate reductase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005750 name: mitochondrial respiratory chain complex III namespace: cellular_component alt_id: GO:0015008 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex" EXACT [] synonym: "mitochondrial coenzyme Q-cytochrome c reductase complex" EXACT [] synonym: "mitochondrial complex III" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc] synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc] is_a: GO:0045275 ! respiratory chain complex III is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045275 ! respiratory chain complex III intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005751 name: mitochondrial respiratory chain complex IV namespace: cellular_component alt_id: GO:0005752 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045277 ! respiratory chain complex IV is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045277 ! respiratory chain complex IV intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005753 name: mitochondrial proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0016470 def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] synonym: "mitochondrial respiratory chain complex V" EXACT [] is_a: GO:0045259 ! proton-transporting ATP synthase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045259 ! proton-transporting ATP synthase complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005754 name: mitochondrial proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045267 ! proton-transporting ATP synthase, catalytic core intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005755 name: obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" EXACT [] is_obsolete: true consider: GO:0045263 [Term] id: GO:0005756 name: mitochondrial proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045269 ! proton-transporting ATP synthase, central stalk intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005757 name: mitochondrial permeability transition pore complex namespace: cellular_component def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078] synonym: "mitochondrial PT pore complex" EXACT [] synonym: "MPTP complex" EXACT [] synonym: "PTPC" BROAD [PMID:21760595] is_a: GO:0046930 ! pore complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005758 name: mitochondrial intermembrane space namespace: cellular_component alt_id: GO:0031971 def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: MIPS_funcat:70.16.03 xref: NIF_Subcellular:sao118944228 is_a: GO:0031970 ! organelle envelope lumen relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component alt_id: GO:0031980 def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: MIPS_funcat:70.16.07 xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005760 name: gamma DNA polymerase complex namespace: cellular_component def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005762 name: mitochondrial large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] synonym: "39S ribosomal subunit, mitochondrial" NARROW [] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0005761 ! mitochondrial ribosome relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005763 name: mitochondrial small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] synonym: "28S ribosomal subunit, mitochondrial" NARROW [] synonym: "mitochondrial ribosomal small subunit complex" EXACT [] synonym: "mitochondrial ribosomal SSU complex" EXACT [] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0005761 ! mitochondrial ribosome relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: MIPS_funcat:70.25 xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] synonym: "lysosome membrane" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005767 name: secondary lysosome namespace: cellular_component def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1549842807 is_a: GO:0005764 ! lysosome [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant xref: MIPS_funcat:70.22 xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005769 name: early endosome namespace: cellular_component def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] xref: NIF_Subcellular:nlx_subcell_20090701 is_a: GO:0005768 ! endosome [Term] id: GO:0005770 name: late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] synonym: "prevacuolar compartment" EXACT [] synonym: "PVC" BROAD [] xref: NIF_Subcellular:nlx_subcell_20090702 is_a: GO:0005768 ! endosome [Term] id: GO:0005771 name: multivesicular body namespace: cellular_component def: "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] synonym: "multivesicular endosome" EXACT [PMID:12122203] synonym: "MVB" EXACT [] synonym: "MVE" EXACT [PMID:12122203] xref: NIF_Subcellular:sao2045955158 is_a: GO:0005770 ! late endosome [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: MIPS_funcat:70.25 xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0005776 name: autophagosome namespace: cellular_component def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] xref: NIF_Subcellular:sao8663416959 is_a: GO:0005773 ! vacuole [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisomal" RELATED [] synonym: "peroxisome vesicle" BROAD [] xref: MIPS_funcat:70.19 xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0042579 ! microbody [Term] id: GO:0005778 name: peroxisomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] synonym: "peroxisome membrane" EXACT [] is_a: GO:0031903 ! microbody membrane relationship: part_of GO:0005777 ! peroxisome [Term] id: GO:0005779 name: integral component of peroxisomal membrane namespace: cellular_component def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] synonym: "integral to peroxisomal membrane" NARROW [] is_a: GO:0031231 ! intrinsic component of peroxisomal membrane is_a: GO:0031301 ! integral component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0005780 name: extrinsic component of intraperoxisomal membrane namespace: cellular_component def: "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] synonym: "extrinsic to intraperoxisomal membrane" EXACT [] synonym: "intra-peroxisomal peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005778 ! peroxisomal membrane relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0005781 name: obsolete peroxisome targeting signal receptor complex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. synonym: "peroxisome targeting signal receptor complex" EXACT [] is_obsolete: true consider: GO:0000268 consider: GO:0006625 [Term] id: GO:0005782 name: peroxisomal matrix namespace: cellular_component alt_id: GO:0031909 def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] synonym: "peroxisomal lumen" EXACT [] is_a: GO:0031907 ! microbody lumen relationship: part_of GO:0005777 ! peroxisome [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: MIPS_funcat:70.07 xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005784 name: Sec61 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647] synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex [Term] id: GO:0005785 name: signal recognition particle receptor complex namespace: cellular_component def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732] synonym: "docking protein complex" RELATED [] synonym: "SR complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0005786 name: signal recognition particle, endoplasmic reticulum targeting namespace: cellular_component alt_id: GO:0005855 def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] synonym: "signal sequence receptor complex" EXACT [] synonym: "SRP" EXACT [] xref: Wikipedia:Signal_recognition_particle is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0005787 name: signal peptidase complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] is_a: GO:0098796 ! membrane protein complex is_a: GO:1905368 ! peptidase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0005788 name: endoplasmic reticulum lumen namespace: cellular_component alt_id: GO:0016022 def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "endoplasmic reticulum cisterna" EXACT [] synonym: "ER cisterna" EXACT [] synonym: "ER lumen" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005789 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005790 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] synonym: "SER" EXACT [] synonym: "smooth ER" EXACT [] xref: NIF_Subcellular:sao710427438 xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005791 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] synonym: "RER" EXACT [] synonym: "rough ER" EXACT [] xref: NIF_Subcellular:sao1881364067 xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005792 name: obsolete microsome namespace: cellular_component def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "microsomal membrane" RELATED [] synonym: "microsome" EXACT [] xref: Wikipedia:Microsome is_obsolete: true consider: GO:0043231 [Term] id: GO:0005793 name: endoplasmic reticulum-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] synonym: "EGTC" EXACT [] synonym: "endoplasmic reticulum-Golgi transport container" EXACT [] synonym: "ER-Golgi intermediate compartment" EXACT [] synonym: "ER-Golgi transport container" EXACT [] synonym: "ERGIC" EXACT [] synonym: "pre-Golgi intermediate compartment" EXACT [] synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster] synonym: "VTC" EXACT [] xref: Wikipedia:Vesicular-tubular_cluster is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: MIPS_funcat:70.08 xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005795 name: Golgi stack namespace: cellular_component alt_id: GO:0016940 def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] is_a: GO:0098791 ! Golgi subcompartment [Term] id: GO:0005796 name: Golgi lumen namespace: cellular_component def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0005797 name: Golgi medial cisterna namespace: cellular_component def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005799 name: obsolete coatomer namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. synonym: "coatomer" EXACT [] synonym: "COPI vesicle" RELATED [] is_obsolete: true consider: GO:0030126 consider: GO:0030137 [Term] id: GO:0005800 name: obsolete COPII vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "COPII vesicle" EXACT [] is_obsolete: true consider: GO:0030134 [Term] id: GO:0005801 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle. synonym: "cis face" BROAD [NIF_Subcellular:sao632188024] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] xref: NIF_Subcellular:sao632188024 is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0005802 name: trans-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part. synonym: "Golgi trans face" RELATED [] synonym: "Golgi trans-face" RELATED [] synonym: "late Golgi" RELATED [GOC:mah] synonym: "maturing face" RELATED [] synonym: "TGN" EXACT [] synonym: "trans face" BROAD [NIF_Subcellular:sao1039242387] synonym: "trans Golgi network" EXACT [] xref: NIF_Subcellular:sao9456487 is_a: GO:0098791 ! Golgi subcompartment [Term] id: GO:0005803 name: obsolete secretory vesicle namespace: cellular_component def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] comment: This term was made obsolete because it was being used to describe two different components. synonym: "secretory vesicle" EXACT [] synonym: "transition vesicle" NARROW [] is_obsolete: true consider: GO:0030133 consider: GO:0030141 [Term] id: GO:0005804 name: obsolete secretory vesicle membrane namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its parent was made obsolete. synonym: "secretory vesicle membrane" EXACT [] is_obsolete: true consider: GO:0030658 consider: GO:0030667 [Term] id: GO:0005805 name: obsolete ER-Golgi transport vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "ER-Golgi transport vesicle" EXACT [] is_obsolete: true consider: GO:0030134 [Term] id: GO:0005806 name: obsolete Golgi-ER transport vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "Golgi-ER transport vesicle" EXACT [] is_obsolete: true consider: GO:0030142 [Term] id: GO:0005808 name: obsolete Golgi-plasma membrane transport vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. synonym: "Golgi-plasma membrane transport vesicle" EXACT [] is_obsolete: true consider: GO:0030133 [Term] id: GO:0005809 name: obsolete Golgi-vacuole transport vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "Golgi-vacuole transport vesicle" EXACT [] is_obsolete: true consider: GO:0030133 [Term] id: GO:0005810 name: obsolete endocytotic transport vesicle namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "endocytotic transport vesicle" EXACT [] is_obsolete: true replaced_by: GO:0030139 [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005813 name: centrosome namespace: cellular_component def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] subset: goslim_pir xref: MIPS_funcat:70.05 xref: Wikipedia:Centrosome is_a: GO:0005815 ! microtubule organizing center relationship: has_part GO:0005814 ! centriole [Term] id: GO:0005814 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "daughter centriole" NARROW [GOC:cilia] synonym: "mother centriole" NARROW [GOC:cilia] xref: NIF_Subcellular:sao95019936 xref: Wikipedia:Centriole is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005815 ! microtubule organizing center [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005816 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] synonym: "SPB" EXACT [GOC:mah] xref: Wikipedia:Spindle_pole_body is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0005817 name: obsolete centrosomal mitotic factor namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:clt] comment: This term was made obsolete because it was not defined. synonym: "centrosomal mitotic factor" EXACT [] is_obsolete: true [Term] id: GO:0005818 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0099080 ! supramolecular complex relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005821 name: intermediate layer of spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005822 name: inner plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005823 name: central plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005824 name: outer plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005825 name: half bridge of spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005826 name: actomyosin contractile ring namespace: cellular_component alt_id: GO:0030480 def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606] synonym: "actomyosin ring" RELATED [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "cytokinetic ring" RELATED [] is_a: GO:0070938 ! contractile ring relationship: part_of GO:0030864 ! cortical actin cytoskeleton relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0005827 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0000922 ! spindle pole relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005828 name: kinetochore microtubule namespace: cellular_component def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] synonym: "pole-to-kinetochore microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005831 name: steroid hormone aporeceptor complex namespace: cellular_component def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005832 name: chaperonin-containing T-complex namespace: cellular_component def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] synonym: "CCT particle" EXACT [] synonym: "TriC" EXACT [] is_a: GO:0101031 ! chaperone complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005833 name: hemoglobin complex namespace: cellular_component def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732] synonym: "haemoglobin complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005834 name: heterotrimeric G-protein complex namespace: cellular_component def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684] comment: See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'. synonym: "heterotrimeric G-protein GTPase activity" RELATED [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1905360 ! GTPase complex relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane [Term] id: GO:0005835 name: fatty acid synthase complex namespace: cellular_component alt_id: GO:0031373 alt_id: GO:0031374 def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840] subset: goslim_pir synonym: "cytosolic FAS complex" EXACT [] synonym: "cytosolic fatty acid synthase complex" EXACT [] synonym: "cytosolic type I FAS complex" EXACT [] synonym: "cytosolic type I fatty acid synthase complex" EXACT [] synonym: "FAS complex" EXACT [] synonym: "fatty acid synthetase complex" EXACT [] synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] xref: Wikipedia:Fatty_acid_synthetase_complex is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005836 name: fatty-acyl-CoA synthase complex namespace: cellular_component def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. synonym: "fatty acyl CoA synthase complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005837 name: obsolete 26S proteasome namespace: cellular_component def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] comment: This term was made obsolete because its definition was inaccurate. synonym: "26S proteasome" EXACT [] is_obsolete: true consider: GO:0000502 [Term] id: GO:0005838 name: proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] synonym: "19S regulatory particle" NARROW [] synonym: "modulator complex" RELATED [CORUM:28] synonym: "PA700 proteasome activator" NARROW [] synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0005839 name: proteasome core complex namespace: cellular_component alt_id: GO:0000503 def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] subset: goslim_metagenomics synonym: "20S core complex" NARROW [] synonym: "20S proteasome" NARROW [GOC:cjk] synonym: "macropain" EXACT [] synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005844 name: polysome namespace: cellular_component def: "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871] subset: goslim_pir synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871] xref: NIF_Subcellular:sao1038025871 xref: Wikipedia:Polysome is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005845 name: mRNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] synonym: "mRNA cap complex" RELATED [] is_a: GO:0034518 ! RNA cap binding complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005846 name: nuclear cap binding complex namespace: cellular_component def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] comment: Note that this complex can be found in the cytoplasm as well as the nucleus. synonym: "CBC" RELATED [] synonym: "mRNA cap binding complex" NARROW [] synonym: "NCBP-NIP1 complex" NARROW [] synonym: "snRNA cap binding complex" NARROW [] is_a: GO:0034518 ! RNA cap binding complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005847 name: mRNA cleavage and polyadenylation specificity factor complex namespace: cellular_component def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] synonym: "CFII complex" RELATED [] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "CPF complex" NARROW [] synonym: "CPSF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005848 name: mRNA cleavage stimulating factor complex namespace: cellular_component def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "CstF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005849 name: mRNA cleavage factor complex namespace: cellular_component def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0005850 name: eukaryotic translation initiation factor 2 complex namespace: cellular_component def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] synonym: "eIF-2" EXACT [] synonym: "eIF2" EXACT [GOC:mah] xref: Wikipedia:EIF-2 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005851 name: eukaryotic translation initiation factor 2B complex namespace: cellular_component def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] synonym: "eIF-2B" EXACT [] synonym: "eif2B" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005852 name: eukaryotic translation initiation factor 3 complex namespace: cellular_component def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] synonym: "eIF-3" EXACT [] synonym: "eIF3" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005853 name: eukaryotic translation elongation factor 1 complex namespace: cellular_component def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005854 name: nascent polypeptide-associated complex namespace: cellular_component def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] synonym: "NAC" EXACT [] synonym: "NACA" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:70.04 xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005858 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex intersection_of: GO:0030286 ! dynein complex intersection_of: part_of GO:0005930 ! axoneme relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0005859 name: muscle myosin complex namespace: cellular_component def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] is_a: GO:0016460 ! myosin II complex intersection_of: GO:0016460 ! myosin II complex intersection_of: part_of GO:0043292 ! contractile fiber relationship: part_of GO:0043292 ! contractile fiber [Term] id: GO:0005861 name: troponin complex namespace: cellular_component def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005862 name: muscle thin filament tropomyosin namespace: cellular_component def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005863 name: striated muscle myosin thick filament namespace: cellular_component def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0032982 ! myosin filament is_a: GO:0036379 ! myofilament relationship: has_part GO:0005859 ! muscle myosin complex relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005865 name: striated muscle thin filament namespace: cellular_component def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] is_a: GO:0036379 ! myofilament relationship: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005868 name: cytoplasmic dynein complex namespace: cellular_component def: "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311] comment: Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex. synonym: "cytoplasmic dynein heavy chain" NARROW [] synonym: "cytoplasmic dynein intermediate chain" NARROW [] synonym: "cytoplasmic dynein intermediate light chain" NARROW [] synonym: "cytoplasmic dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex [Term] id: GO:0005869 name: dynactin complex namespace: cellular_component def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005870 name: actin capping protein of dynactin complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499] is_a: GO:0008290 ! F-actin capping protein complex intersection_of: GO:0008290 ! F-actin capping protein complex intersection_of: part_of GO:0005869 ! dynactin complex relationship: part_of GO:0005869 ! dynactin complex [Term] id: GO:0005871 name: kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0005872 name: minus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005873 name: plus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005875 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005876 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005819 ! spindle relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005930 ! axoneme relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005882 name: intermediate filament namespace: cellular_component def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: FMA:63851 xref: NIF_Subcellular:sao952483289 xref: Wikipedia:Intermediate_filament is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0045111 ! intermediate filament cytoskeleton [Term] id: GO:0005883 name: neurofilament namespace: cellular_component def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194] synonym: "type IV intermediate filament" EXACT [] xref: NIF_Subcellular:sao1316272517 xref: Wikipedia:Neurofilament is_a: GO:0005882 ! intermediate filament relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005885 name: Arp2/3 protein complex namespace: cellular_component def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005887 name: integral component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] synonym: "integral to plasma membrane" NARROW [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0005888 name: obsolete proteoglycan integral to plasma membrane namespace: cellular_component def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. synonym: "proteoglycan integral to plasma membrane" EXACT [] is_obsolete: true replaced_by: GO:0005887 [Term] id: GO:0005889 name: potassium:proton exchanging ATPase complex namespace: cellular_component def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] synonym: "hydrogen:potassium-exchanging ATPase complex" EXACT [] synonym: "proton pump" BROAD [] is_a: GO:0090533 ! cation-transporting ATPase complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005890 name: sodium:potassium-exchanging ATPase complex namespace: cellular_component def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] is_a: GO:0090533 ! cation-transporting ATPase complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005891 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0005892 name: acetylcholine-gated channel complex namespace: cellular_component def: "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462] synonym: "nicotinic acetylcholine receptor" BROAD [] synonym: "nicotinic acetylcholine-gated receptor-channel complex" EXACT [GOC:bf] is_a: GO:0034702 ! ion channel complex is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005893 name: interleukin-2 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] synonym: "IL-2 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005894 name: interleukin-3 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] synonym: "IL-3 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005895 name: interleukin-5 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] synonym: "IL-5 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005896 name: interleukin-6 receptor complex namespace: cellular_component def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] synonym: "IL-6 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005897 name: interleukin-9 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] synonym: "IL-9 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005898 name: interleukin-13 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879] synonym: "IL-13 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005899 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732] is_a: GO:0098802 ! plasma membrane signaling receptor complex is_a: GO:1902911 ! protein kinase complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005900 name: oncostatin-M receptor complex namespace: cellular_component def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005901 name: caveola namespace: cellular_component alt_id: GO:0016599 def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198] synonym: "caveolae" EXACT [] synonym: "caveolar membrane" RELATED [] xref: Wikipedia:Caveolae is_a: GO:0044853 ! plasma membrane raft [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: has_part GO:0032432 ! actin filament bundle [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0098862 ! cluster of actin-based cell projections relationship: has_part GO:0005902 ! microvillus [Term] id: GO:0005905 name: clathrin-coated pit namespace: cellular_component def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] synonym: "coated pit" EXACT [GOC:bf] xref: NIF_Subcellular:sao1969557946 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0012505 ! endomembrane system relationship: part_of GO:0016020 ! membrane [Term] id: GO:0005906 name: obsolete clathrin adaptor namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. synonym: "adaptin" RELATED [] synonym: "clathrin adaptor" EXACT [] is_obsolete: true replaced_by: GO:0030119 [Term] id: GO:0005907 name: obsolete HA1 clathrin adaptor namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP1" RELATED [] synonym: "HA1 clathrin adaptor" EXACT [] is_obsolete: true consider: GO:0030121 [Term] id: GO:0005908 name: obsolete HA2 clathrin adaptor namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP2" RELATED [] synonym: "HA2 clathrin adaptor" EXACT [] is_obsolete: true consider: GO:0030122 [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] xref: MIPS_funcat:70.06.04 xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005912 name: adherens junction namespace: cellular_component alt_id: GO:0005913 def: "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] synonym: "cell-cell adherens junction" EXACT [] xref: Wikipedia:Adherens_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0005914 name: spot adherens junction namespace: cellular_component def: "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] synonym: "dense plaque" BROAD [] synonym: "punctum adherens" EXACT [] is_a: GO:0005912 ! adherens junction [Term] id: GO:0005915 name: zonula adherens namespace: cellular_component def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] synonym: "adhesion belt" EXACT [] synonym: "belt desmosome" EXACT [] synonym: "intermediate junction" EXACT [] synonym: "zonula adhaerens" EXACT [] xref: NIF_Subcellular:sao1400623473 is_a: GO:0005912 ! adherens junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005916 name: fascia adherens namespace: cellular_component def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910] xref: Wikipedia:Fascia_adherens is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0014704 ! intercalated disc [Term] id: GO:0005917 name: nephrocyte diaphragm namespace: cellular_component def: "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] synonym: "nephrocyte junction" RELATED [PMID:8314002] is_a: GO:0036056 ! filtration diaphragm [Term] id: GO:0005918 name: septate junction namespace: cellular_component def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods." [ISBN:0815332181, PMID:11700298, PMID:12612641, PMID:20795303, PMID:28636800] synonym: "septate desmosome" RELATED [] xref: NIF_Subcellular:sao427941916 is_a: GO:0070160 ! tight junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005919 name: pleated septate junction namespace: cellular_component def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] synonym: "pleated desmosome" RELATED [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005920 name: smooth septate junction namespace: cellular_component def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] synonym: "zonula continua" EXACT [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005921 name: gap junction namespace: cellular_component def: "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins." [GOC:mah, GOC:mtg_muscle, http://en.wikipedia.org/wiki/Gap_junction, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181, PMID:22366062] synonym: "communicating junction" EXACT [] synonym: "electrical synapse" RELATED [http:http\://en.wikipedia.org/wiki/Gap_junction] synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "gap junction macula" EXACT [NIF_Subcellular:sao700839054] synonym: "gap junction plaque" EXACT [NIF_Subcellular:sao700839054] synonym: "intercellular gap junction channel" RELATED [] synonym: "macula communicans" EXACT [] synonym: "zonula communicans" EXACT [] xref: NIF_Subcellular:sao118541872 xref: Wikipedia:Gap_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0005922 name: connexin complex namespace: cellular_component def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] synonym: "connexon" EXACT [GOC:cjm] synonym: "connexon complex" RELATED [] xref: NIF_Subcellular:sao445019788 is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005921 ! gap junction [Term] id: GO:0005923 name: bicellular tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! tight junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005924 name: obsolete cell-substrate adherens junction namespace: cellular_component def: "OBSOLETE. An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] comment: The reason for obsoletion is that, based on the most recent literature, there is no such structure in biology as 'cell-substrate adherens junction'. An 'adherens junction' is always a 'cell-cell junction' (PMIDs: 20571587, 17854762, 21422226, 28096264, 28401269, 26923917). synonym: "hemi-adherens junction" RELATED [] xref: MIPS_funcat:70.06.03 is_obsolete: true [Term] id: GO:0005925 name: focal adhesion namespace: cellular_component alt_id: GO:0005926 alt_id: GO:0008357 def: "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] synonym: "adhesion plaque" RELATED [PMID:3332661] synonym: "connecting hemi-adherens junction" EXACT [] synonym: "focal contact" EXACT [] synonym: "HAJ" EXACT [] synonym: "hemi-adherens junction" EXACT [] xref: Wikipedia:Focal_adhesion is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0005927 name: muscle tendon junction namespace: cellular_component def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0005928 name: obsolete apical hemi-adherens junction namespace: cellular_component def: "OBSOLETE. A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] comment: The reason for obsoletion is that this term has not been used for GO annotation at all since 2001 when it was created, it has no children, it is not a part of any subset/slim. synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah] synonym: "apical dense plaque" EXACT [] is_obsolete: true [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0030990 ! intraciliary transport particle [Term] id: GO:0005930 name: axoneme namespace: cellular_component alt_id: GO:0035085 alt_id: GO:0035086 def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. subset: goslim_pir synonym: "ciliary axoneme" EXACT [] synonym: "cilium axoneme" EXACT [] synonym: "flagellar axoneme" EXACT [] synonym: "flagellum axoneme" EXACT [] xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005874 ! microtubule relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0097014 ! ciliary plasm [Term] id: GO:0005931 name: axonemal nexin link namespace: cellular_component def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [GOC:cilia, GOC:krc, ISBN:0198506732, PMID:21586547, PMID:21728999, PMID:22683354, PMID:9295136] synonym: "axonemal interdoublet link" EXACT [] synonym: "nexin complex" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0005933 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast xref: MIPS_funcat:70.29 is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005934 name: cellular bud tip namespace: cellular_component def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005935 name: cellular bud neck namespace: cellular_component def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005936 name: obsolete shmoo namespace: cellular_component def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. synonym: "shmoo" EXACT [] is_obsolete: true consider: GO:0001400 consider: GO:0005937 [Term] id: GO:0005937 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0071944 ! cell periphery relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005940 name: septin ring namespace: cellular_component alt_id: GO:0030481 def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] xref: Wikipedia:Septin_ring is_a: GO:0032156 ! septin cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0005941 name: obsolete unlocalized protein complex namespace: cellular_component def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. synonym: "unlocalized protein complex" EXACT [] is_obsolete: true [Term] id: GO:0005942 name: phosphatidylinositol 3-kinase complex namespace: cellular_component def: "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] comment: For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/ subset: goslim_pir synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] synonym: "phosphoinositide 3-kinase complex" EXACT [] synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575] synonym: "PI3K complex" EXACT [] synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429] synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0019898 ! extrinsic component of membrane [Term] id: GO:0005943 name: phosphatidylinositol 3-kinase complex, class IA namespace: cellular_component alt_id: GO:0035030 def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] synonym: "class IA PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I [Term] id: GO:0005944 name: phosphatidylinositol 3-kinase complex, class IB namespace: cellular_component alt_id: GO:0035031 def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex" EXACT [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] synonym: "class IB PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I [Term] id: GO:0005945 name: 6-phosphofructokinase complex namespace: cellular_component def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005946 name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) namespace: cellular_component def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. synonym: "trehalose-6-phosphate synthase complex" EXACT [] synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005947 name: mitochondrial alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex intersection_of: GO:0045240 ! dihydrolipoyl dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005948 name: acetolactate synthase complex namespace: cellular_component def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. synonym: "acetohydroxyacid synthase complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005949 name: obsolete aminoadipate-semialdehyde dehydrogenase complex namespace: cellular_component def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. synonym: "aminoadipate-semialdehyde dehydrogenase complex" EXACT [] is_obsolete: true [Term] id: GO:0005950 name: anthranilate synthase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005951 name: carbamoyl-phosphate synthase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] synonym: "carbamoyl phosphate synthase complex" EXACT [] synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005952 name: cAMP-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] synonym: "PKA" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005953 name: CAAX-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005954 name: calcium- and calmodulin-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] synonym: "CAMK2" EXACT [] synonym: "CaMKII" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005955 name: calcineurin complex namespace: cellular_component def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871] synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] synonym: "protein phosphatase type 2B complex" EXACT [] is_a: GO:0008287 ! protein serine/threonine phosphatase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005956 name: protein kinase CK2 complex namespace: cellular_component def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. synonym: "casein kinase II complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005957 name: obsolete debranching enzyme namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. synonym: "debranching enzyme" EXACT [] is_obsolete: true consider: GO:0043033 [Term] id: GO:0005958 name: DNA-dependent protein kinase-DNA ligase 4 complex namespace: cellular_component alt_id: GO:0005959 def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] is_a: GO:0070419 ! nonhomologous end joining complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005960 name: glycine cleavage complex namespace: cellular_component alt_id: GO:0005961 alt_id: GO:0070015 def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] subset: goslim_pir synonym: "glycine cleavage system" EXACT [] synonym: "glycine decarboxylase complex" EXACT [] synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] xref: Wikipedia:Glycine_decarboxylase_complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005962 name: mitochondrial isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) intersection_of: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005963 name: magnesium-dependent protein serine/threonine phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005964 name: phosphorylase kinase complex namespace: cellular_component def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005965 name: protein farnesyltransferase complex namespace: cellular_component def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005966 name: cyclic-nucleotide phosphodiesterase complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0005967 name: mitochondrial pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD [] is_a: GO:0045254 ! pyruvate dehydrogenase complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005968 name: Rab-protein geranylgeranyltransferase complex namespace: cellular_component def: "An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein)." [GOC:jl, PMID:11886217] synonym: "GGTase-II complex" EXACT [] synonym: "Rab geranylgeranyltransferase complex" EXACT [] synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] synonym: "RabGGTase complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005969 name: serine-pyruvate aminotransferase complex namespace: cellular_component alt_id: GO:0005970 def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005971 name: ribonucleoside-diphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1] synonym: "ribonucleotide reductase complex" EXACT [GOC:mah] synonym: "RNR complex" EXACT [GOC:mah] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0005972 name: obsolete fibrinogen alpha chain namespace: cellular_component alt_id: GO:0008005 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen alpha chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005973 name: obsolete fibrinogen beta chain namespace: cellular_component alt_id: GO:0008006 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen beta chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005974 name: obsolete fibrinogen gamma chain namespace: cellular_component alt_id: GO:0008007 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen gamma chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: MIPS_funcat:01.05 xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: janelomax creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process alt_id: GO:0044263 def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] subset: goslim_pir synonym: "glycan metabolic process" NARROW [] synonym: "glycan metabolism" NARROW [] synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] synonym: "glycogen metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0006112 ! energy reserve metabolic process [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:GLYCOGENSYNTH-PWY xref: MIPS_funcat:01.05.01.03.02.01 is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005978 ! glycogen biosynthetic process relationship: regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] synonym: "glycogenolysis" EXACT [GOC:sl] xref: MetaCyc:GLYCOCAT-PWY is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] synonym: "regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005980 ! glycogen catabolic process relationship: regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0005982 name: starch metabolic process namespace: biological_process def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732] synonym: "starch metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0005983 name: starch catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch breakdown" EXACT [] synonym: "starch catabolism" EXACT [] synonym: "starch degradation" EXACT [] xref: MetaCyc:PWY-842 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005984 name: disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:0192800981] synonym: "disaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005985 name: sucrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005986 name: sucrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose anabolism" EXACT [] synonym: "sucrose biosynthesis" EXACT [] synonym: "sucrose formation" EXACT [] synonym: "sucrose synthesis" EXACT [] xref: MetaCyc:SUCSYN-PWY is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005987 name: sucrose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose breakdown" EXACT [] synonym: "sucrose catabolism" EXACT [] synonym: "sucrose degradation" EXACT [] is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005988 name: lactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005989 name: lactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose anabolism" EXACT [] synonym: "lactose biosynthesis" EXACT [] synonym: "lactose formation" EXACT [] synonym: "lactose synthesis" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005990 name: lactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose breakdown" EXACT [] synonym: "lactose catabolism" EXACT [] synonym: "lactose degradation" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005991 name: trehalose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose metabolic process" EXACT [] synonym: "mycose metabolism" EXACT [] synonym: "mykose metabolic process" EXACT [] synonym: "mykose metabolism" EXACT [] synonym: "trehalose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005992 name: trehalose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose biosynthesis" EXACT [] synonym: "mycose biosynthetic process" EXACT [] synonym: "mykose biosynthesis" EXACT [] synonym: "mykose biosynthetic process" EXACT [] synonym: "trehalose anabolism" EXACT [] synonym: "trehalose biosynthesis" EXACT [] synonym: "trehalose formation" EXACT [] synonym: "trehalose synthesis" EXACT [] xref: MetaCyc:PWY-881 xref: MetaCyc:TREHALOSESYN-PWY xref: MetaCyc:TRESYN-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005993 name: trehalose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose catabolic process" EXACT [] synonym: "mycose catabolism" EXACT [] synonym: "mykose catabolic process" EXACT [] synonym: "mykose catabolism" EXACT [] synonym: "trehalose breakdown" EXACT [] synonym: "trehalose catabolism" EXACT [] synonym: "trehalose degradation" EXACT [] xref: MetaCyc:TREDEGLOW-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005994 name: melibiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] synonym: "melibiose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005995 name: melibiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] synonym: "melibiose breakdown" EXACT [] synonym: "melibiose catabolism" EXACT [] synonym: "melibiose degradation" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0005997 name: xylulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0005998 name: xylulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose breakdown" EXACT [] synonym: "xylulose catabolism" EXACT [] synonym: "xylulose degradation" EXACT [] xref: MetaCyc:XYLCAT-PWY is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0005999 name: xylulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose anabolism" EXACT [] synonym: "xylulose biosynthesis" EXACT [] synonym: "xylulose formation" EXACT [] synonym: "xylulose synthesis" EXACT [] is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0006000 name: fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732] synonym: "fructose metabolism" EXACT [] xref: Wikipedia:Fructose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006001 name: fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] synonym: "fructose breakdown" EXACT [] synonym: "fructose catabolism" EXACT [] synonym: "fructose degradation" EXACT [] is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006002 name: fructose 6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732] synonym: "fructose 6-phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006003 name: fructose 2,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732] synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006004 name: fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] synonym: "fucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006005 name: L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] synonym: "L-fucose anabolism" EXACT [] synonym: "L-fucose biosynthesis" EXACT [] synonym: "L-fucose formation" EXACT [] synonym: "L-fucose synthesis" EXACT [] is_a: GO:0042353 ! fucose biosynthetic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006009 name: glucose 1-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] is_a: GO:0016310 ! phosphorylation is_a: GO:0019255 ! glucose 1-phosphate metabolic process [Term] id: GO:0006011 name: UDP-glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006012 name: galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] synonym: "galactose metabolism" EXACT [] xref: Wikipedia:Galactose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006013 name: mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732] synonym: "mannose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006014 name: D-ribose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732] synonym: "D-ribose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0006015 name: 5-phosphoribose 1-diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] synonym: "PRPP biosynthetic process" EXACT [] xref: MetaCyc:PWY0-661 is_a: GO:0046390 ! ribose phosphate biosynthetic process is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process [Term] id: GO:0006016 name: 2-deoxyribose 1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732] synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] synonym: "2-deoxyribose 1-phosphate formation" EXACT [] synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0006017 name: deoxyribose 1,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process [Term] id: GO:0006018 name: 2-deoxyribose 1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] synonym: "2-deoxyribose 1-phosphate breakdown" EXACT [] synonym: "2-deoxyribose 1-phosphate catabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate degradation" EXACT [] synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0006019 name: deoxyribose 5-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] is_a: GO:0016310 ! phosphorylation is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process [Term] id: GO:0006020 name: inositol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684] synonym: "inositol metabolism" EXACT [] synonym: "myo-inositol metabolic process" NARROW [] synonym: "myo-inositol metabolism" NARROW [] synonym: "vitamin Bh metabolic process" EXACT [] synonym: "vitamin Bh metabolism" EXACT [] xref: Wikipedia:Inositol is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0006021 name: inositol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684] synonym: "inositol anabolism" EXACT [] synonym: "inositol biosynthesis" EXACT [] synonym: "inositol formation" EXACT [] synonym: "inositol synthesis" EXACT [] synonym: "myo-inositol biosynthesis" NARROW [] synonym: "myo-inositol biosynthetic process" NARROW [] synonym: "vitamin Bh biosynthesis" EXACT [] synonym: "vitamin Bh biosynthetic process" EXACT [] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006025 name: galactosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] synonym: "galactosaminoglycan anabolism" EXACT [] synonym: "galactosaminoglycan biosynthesis" EXACT [] synonym: "galactosaminoglycan formation" EXACT [] synonym: "galactosaminoglycan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006028 name: galactosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] synonym: "galactosaminoglycan breakdown" EXACT [] synonym: "galactosaminoglycan catabolism" EXACT [] synonym: "galactosaminoglycan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006029 name: proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan metabolism" EXACT [] synonym: "proteoglycan sulfate transfer" NARROW [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006030 name: chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] synonym: "chitin metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006031 name: chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] synonym: "chitin anabolism" EXACT [] synonym: "chitin biosynthesis" EXACT [] synonym: "chitin formation" EXACT [] synonym: "chitin synthesis" EXACT [] xref: MIPS_funcat:01.05.01.03.02.03 is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0006030 ! chitin metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006032 name: chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] synonym: "chitin breakdown" EXACT [] synonym: "chitin catabolism" EXACT [] synonym: "chitin degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0006030 ! chitin metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chitin localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006034 name: cuticle chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006035 name: cuticle chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin anabolism" EXACT [] synonym: "cuticle chitin biosynthesis" EXACT [] synonym: "cuticle chitin formation" EXACT [] synonym: "cuticle chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006034 ! cuticle chitin metabolic process relationship: part_of GO:0040003 ! chitin-based cuticle development [Term] id: GO:0006036 name: cuticle chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin breakdown" EXACT [] synonym: "cuticle chitin catabolism" EXACT [] synonym: "cuticle chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006034 ! cuticle chitin metabolic process [Term] id: GO:0006037 name: cell wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0006038 name: cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin anabolism" EXACT [] synonym: "cell wall chitin biosynthesis" EXACT [] synonym: "cell wall chitin formation" EXACT [] synonym: "cell wall chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006037 ! cell wall chitin metabolic process relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0006039 name: cell wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin breakdown" EXACT [] synonym: "cell wall chitin catabolism" EXACT [] synonym: "cell wall chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006037 ! cell wall chitin metabolic process [Term] id: GO:0006040 name: amino sugar metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "amino sugar metabolism" EXACT [] synonym: "aminosaccharide metabolic process" EXACT [] synonym: "aminosaccharide metabolism" EXACT [] is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006041 name: glucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine metabolic process" EXACT [] synonym: "chitosamine metabolism" EXACT [] synonym: "glucosamine metabolism" EXACT [] is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006042 name: glucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine biosynthesis" EXACT [] synonym: "chitosamine biosynthetic process" EXACT [] synonym: "glucosamine anabolism" EXACT [] synonym: "glucosamine biosynthesis" EXACT [] synonym: "glucosamine formation" EXACT [] synonym: "glucosamine synthesis" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006043 name: glucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine catabolic process" EXACT [] synonym: "chitosamine catabolism" EXACT [] synonym: "glucosamine breakdown" EXACT [] synonym: "glucosamine catabolism" EXACT [] synonym: "glucosamine degradation" EXACT [] xref: MetaCyc:GLUAMCAT-PWY is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006044 name: N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine metabolism" EXACT [] is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006045 name: N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine anabolism" EXACT [] synonym: "N-acetylglucosamine biosynthesis" EXACT [] synonym: "N-acetylglucosamine formation" EXACT [] synonym: "N-acetylglucosamine synthesis" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006046 name: N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine breakdown" EXACT [] synonym: "N-acetylglucosamine catabolism" EXACT [] synonym: "N-acetylglucosamine degradation" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006047 name: UDP-N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006048 name: UDP-N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-GlcNAc biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine formation" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] xref: MetaCyc:UDPNAGSYN-PWY is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0006049 name: UDP-N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] synonym: "UDP-N-acetylglucosamine degradation" EXACT [] is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0006050 name: mannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators] synonym: "mannosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006051 name: N-acetylmannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine metabolism" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process [Term] id: GO:0006052 name: N-acetylmannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine anabolism" EXACT [] synonym: "N-acetylmannosamine biosynthesis" EXACT [] synonym: "N-acetylmannosamine formation" EXACT [] synonym: "N-acetylmannosamine synthesis" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046347 ! mannosamine biosynthetic process [Term] id: GO:0006053 name: N-acetylmannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine breakdown" EXACT [] synonym: "N-acetylmannosamine catabolism" EXACT [] synonym: "N-acetylmannosamine degradation" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046346 ! mannosamine catabolic process [Term] id: GO:0006054 name: N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] synonym: "N-acetylneuraminate metabolism" EXACT [] synonym: "sialic acid metabolic process" BROAD [] synonym: "sialic acid metabolism" BROAD [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006055 name: CMP-N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] synonym: "CMP-N-acetylneuraminate formation" EXACT [] synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process [Term] id: GO:0006056 name: mannoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006057 name: mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein anabolism" EXACT [] synonym: "mannoprotein biosynthesis" EXACT [] synonym: "mannoprotein formation" EXACT [] synonym: "mannoprotein synthesis" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006058 name: mannoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein breakdown" EXACT [] synonym: "mannoprotein catabolism" EXACT [] synonym: "mannoprotein degradation" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006059 name: hexitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol metabolism" EXACT [] synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] synonym: "sugar alcohol (hexitol) metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006060 name: sorbitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol metabolism" EXACT [] xref: MetaCyc:P461-PWY is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0006061 name: sorbitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol anabolism" EXACT [] synonym: "sorbitol biosynthesis" EXACT [] synonym: "sorbitol formation" EXACT [] synonym: "sorbitol synthesis" EXACT [] is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0006062 name: sorbitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol breakdown" EXACT [] synonym: "sorbitol catabolism" EXACT [] synonym: "sorbitol degradation" EXACT [] xref: MetaCyc:SORBDEG-PWY is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0006063 name: uronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732] synonym: "uronic acid metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006064 name: glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] synonym: "glucuronate breakdown" EXACT [] synonym: "glucuronate catabolism" EXACT [] synonym: "glucuronate degradation" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0006065 name: UDP-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucuronate anabolism" EXACT [] synonym: "UDP-glucuronate biosynthesis" EXACT [] synonym: "UDP-glucuronate formation" EXACT [] synonym: "UDP-glucuronate synthesis" EXACT [] xref: MetaCyc:PWY-4841 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046398 ! UDP-glucuronate metabolic process [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0006067 name: ethanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0006068 name: ethanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol breakdown" EXACT [] synonym: "ethanol catabolism" EXACT [] synonym: "ethanol degradation" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006069 name: ethanol oxidation namespace: biological_process def: "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006070 name: octanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] synonym: "octanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1903173 ! fatty alcohol metabolic process [Term] id: GO:0006071 name: glycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] synonym: "glycerol metabolism" EXACT [] xref: MetaCyc:GLYCEROLMETAB-PWY is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006072 name: glycerol-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] synonym: "glycerol-3-phosphate metabolism" EXACT [] is_a: GO:0052646 ! alditol phosphate metabolic process [Term] id: GO:0006073 name: cellular glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell." [ISBN:0198547684] synonym: "cellular glucan metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0006074 name: (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [ISBN:0198506732] synonym: "1,3-beta-D-glucan metabolic process" BROAD [GOC:tb] synonym: "1,3-beta-D-glucan metabolism" EXACT [] synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb] synonym: "beta-1,3 glucan metabolic process" EXACT [] synonym: "beta-1,3 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006075 name: (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [GOC:ai] synonym: "1,3-beta-D-glucan biosynthetic process" EXACT [] synonym: "1,3-beta-glucan anabolism" EXACT [] synonym: "1,3-beta-glucan biosynthesis" EXACT [] synonym: "1,3-beta-glucan formation" EXACT [] synonym: "1,3-beta-glucan synthesis" EXACT [] synonym: "beta-1,3 glucan anabolism" EXACT [] synonym: "beta-1,3 glucan biosynthesis" EXACT [] synonym: "beta-1,3 glucan biosynthetic process" EXACT [] synonym: "beta-1,3 glucan formation" EXACT [] synonym: "beta-1,3 glucan synthesis" EXACT [] is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006076 name: (1->3)-beta-D-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans." [GOC:ai] synonym: "1,3-beta-D-glucan catabolic process" EXACT [] synonym: "1,3-beta-glucan breakdown" EXACT [] synonym: "1,3-beta-glucan catabolism" EXACT [] synonym: "1,3-beta-glucan degradation" EXACT [] synonym: "beta-1,3 glucan breakdown" EXACT [] synonym: "beta-1,3 glucan catabolic process" EXACT [] synonym: "beta-1,3 glucan catabolism" EXACT [] synonym: "beta-1,3 glucan degradation" EXACT [] is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006077 name: (1->6)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds." [ISBN:0198506732] synonym: "1,6-beta-glucan metabolic process" EXACT [] synonym: "1,6-beta-glucan metabolism" EXACT [] synonym: "beta-1,6 glucan metabolic process" EXACT [] synonym: "beta-1,6 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006078 name: (1->6)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:ai] synonym: "1,6-beta-glucan anabolism" EXACT [] synonym: "1,6-beta-glucan biosynthesis" EXACT [] synonym: "1,6-beta-glucan biosynthetic process" EXACT [] synonym: "1,6-beta-glucan formation" EXACT [] synonym: "1,6-beta-glucan synthesis" EXACT [] synonym: "beta-1,6 glucan anabolism" EXACT [] synonym: "beta-1,6 glucan biosynthesis" EXACT [] synonym: "beta-1,6 glucan biosynthetic process" EXACT [] synonym: "beta-1,6 glucan formation" EXACT [] synonym: "beta-1,6 glucan synthesis" EXACT [] is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006079 name: (1->6)-beta-D-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans." [GOC:ai] synonym: "1,6-beta-D-glucan breakdown" EXACT [] synonym: "1,6-beta-D-glucan catabolic process" EXACT [] synonym: "1,6-beta-D-glucan catabolism" EXACT [] synonym: "1,6-beta-D-glucan degradation" EXACT [] synonym: "beta-1,6 glucan breakdown" EXACT [] synonym: "beta-1,6 glucan catabolic process" EXACT [] synonym: "beta-1,6 glucan catabolism" EXACT [] synonym: "beta-1,6 glucan degradation" EXACT [] is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006080 name: substituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] synonym: "substituted mannan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0006081 name: cellular aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] subset: goslim_pir synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] xref: MIPS_funcat:01.20.05.03 is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006083 name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006084 name: acetyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] synonym: "acetyl coenzyme A metabolic process" EXACT [] synonym: "acetyl coenzyme A metabolism" EXACT [] synonym: "acetyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0006085 name: acetyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] synonym: "acetyl-CoA anabolism" EXACT [] synonym: "acetyl-CoA biosynthesis" EXACT [] synonym: "acetyl-CoA formation" EXACT [] synonym: "acetyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY-5173 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0006086 name: acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] synonym: "acetyl-CoA formation from pyruvate" EXACT [] synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] synonym: "pyruvate dehydrogenase pathway" EXACT [] xref: MetaCyc:PYRUVDEHYD-PWY is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0006088 name: obsolete acetate to acetyl-CoA namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "acetate to acetyl-CoA" EXACT [] is_obsolete: true consider: GO:0003987 [Term] id: GO:0006089 name: lactate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] synonym: "2-hydroxypropanoate metabolic process" EXACT [] synonym: "2-hydroxypropanoate metabolism" EXACT [] synonym: "alpha-hydroxypropionate metabolic process" EXACT [] synonym: "alpha-hydroxypropionate metabolism" EXACT [] synonym: "lactate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0006090 name: pyruvate metabolic process namespace: biological_process alt_id: GO:0006087 def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] synonym: "pyruvate dehydrogenase bypass" RELATED [] synonym: "pyruvate metabolism" EXACT [] xref: MetaCyc:P41-PWY xref: Wikipedia:Pyruvic_acid is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] xref: MIPS_funcat:02.45.15 is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY xref: MIPS_funcat:02.01 xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0006096 name: glycolytic process namespace: biological_process alt_id: GO:0019641 alt_id: GO:0019642 def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] synonym: "anaerobic glycolysis" RELATED [] synonym: "Embden-Meyerhof pathway" RELATED [] synonym: "Embden-Meyerhof-Parnas pathway" RELATED [] synonym: "glycolysis" RELATED [GOC:dph] synonym: "modifed Embden-Meyerhof pathway" RELATED [] xref: MetaCyc:GLYCOLYSIS-VARIANTS xref: MIPS_funcat:02.01 is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006757 ! ATP generation from ADP is_a: GO:0016052 ! carbohydrate catabolic process relationship: has_part GO:0004618 ! phosphoglycerate kinase activity relationship: has_part GO:0004619 ! phosphoglycerate mutase activity relationship: has_part GO:0004634 ! phosphopyruvate hydratase activity relationship: has_part GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity [Term] id: GO:0006097 name: glyoxylate cycle namespace: biological_process def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] synonym: "glyoxylate bypass" EXACT [] xref: MetaCyc:GLYOXYLATE-BYPASS xref: MIPS_funcat:02.04 xref: Wikipedia:Glyoxylate_cycle is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0046487 ! glyoxylate metabolic process [Term] id: GO:0006098 name: pentose-phosphate shunt namespace: biological_process def: "The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] synonym: "hexose monophosphate pathway" EXACT [] synonym: "pentose phosphate pathway" EXACT [] synonym: "pentose phosphate shunt" EXACT [] synonym: "pentose-phosphate pathway" EXACT [] xref: KEGG_PATHWAY:00030 xref: MetaCyc:PENTOSE-P-PWY xref: MIPS_funcat:02.07 xref: Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens" xref: Wikipedia:Pentose_phosphate_pathway is_a: GO:0006740 ! NADPH regeneration is_a: GO:0051156 ! glucose 6-phosphate metabolic process [Term] id: GO:0006099 name: tricarboxylic acid cycle namespace: biological_process def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] synonym: "citric acid cycle" EXACT [] synonym: "Krebs cycle" EXACT [] synonym: "TCA cycle" EXACT [] xref: MetaCyc:P105-PWY xref: MetaCyc:P42-PWY xref: MetaCyc:TCA xref: MIPS_funcat:02.10 xref: Wikipedia:Tricarboxylic_acid_cycle is_a: GO:0044238 ! primary metabolic process relationship: part_of GO:0009060 ! aerobic respiration [Term] id: GO:0006100 name: obsolete tricarboxylic acid cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "citric acid cycle intermediate metabolic process" EXACT [] synonym: "citric acid cycle intermediate metabolism" EXACT [] synonym: "Krebs cycle intermediate metabolic process" EXACT [] synonym: "Krebs cycle intermediate metabolism" EXACT [] synonym: "TCA intermediate metabolic process" EXACT [] synonym: "TCA intermediate metabolism" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolic process" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] is_obsolete: true consider: GO:0006099 consider: GO:0006101 consider: GO:0006103 consider: GO:0006104 consider: GO:0006105 consider: GO:0006106 consider: GO:0006107 consider: GO:0006108 [Term] id: GO:0006101 name: citrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] synonym: "citrate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0006102 name: isocitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732] synonym: "isocitrate metabolism" EXACT [] is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0006103 name: 2-oxoglutarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732] synonym: "2-ketoglutarate metabolic process" EXACT [] synonym: "2-ketoglutarate metabolism" EXACT [] synonym: "2-oxoglutarate metabolism" EXACT [] synonym: "alpha-ketoglutarate metabolic process" EXACT [] synonym: "alpha-ketoglutarate metabolism" EXACT [] synonym: "alpha-oxoglutarate metabolic process" EXACT [] synonym: "alpha-oxoglutarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006104 name: succinyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] synonym: "succinyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0006105 name: succinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732] synonym: "succinate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006106 name: fumarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732] synonym: "fumarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006107 name: oxaloacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732] synonym: "oxaloacetate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006108 name: malate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] synonym: "malate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005975 ! carbohydrate metabolic process relationship: regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006110 name: regulation of glycolytic process namespace: biological_process alt_id: GO:0090525 def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] synonym: "regulation of glycolysis involved in cellular glucose homeostasis" EXACT [] xref: MIPS_funcat:02.01.03 is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006096 ! glycolytic process relationship: regulates GO:0006096 ! glycolytic process [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process alt_id: GO:0090526 def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED [] synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] xref: MIPS_funcat:02.01.03 is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006094 ! gluconeogenesis relationship: regulates GO:0006094 ! gluconeogenesis created_by: tanyaberardini creation_date: 2013-01-18T12:47:43Z [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir synonym: "energy reserve metabolism" EXACT [] xref: MIPS_funcat:02.19 is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006113 name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, MetaCyc:Fermentation] subset: goslim_pir xref: MetaCyc:FERMENTATION-PWY xref: MIPS_funcat:02.16 xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006114 name: glycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] synonym: "glycerol anabolism" EXACT [] synonym: "glycerol biosynthesis" EXACT [] synonym: "glycerol formation" EXACT [] synonym: "glycerol synthesis" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019401 ! alditol biosynthetic process [Term] id: GO:0006115 name: ethanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol anabolism" EXACT [] synonym: "ethanol biosynthesis" EXACT [] synonym: "ethanol formation" EXACT [] synonym: "ethanol synthesis" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006116 name: NADH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] synonym: "NAD (reduced) dehydrogenation" EXACT [] synonym: "NAD (reduced) oxidation" EXACT [] synonym: "NADH dehydrogenation" EXACT [] synonym: "reduced NAD dehydrogenation" EXACT [] synonym: "reduced NAD oxidation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019674 ! NAD metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006117 name: acetaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators] synonym: "acetaldehyde metabolism" EXACT [] synonym: "ethanal metabolic process" EXACT [] synonym: "ethanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0006118 name: obsolete electron transport namespace: biological_process def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators] comment: This term was made obsolete because it describes a molecular function. synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "electron transport" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] is_obsolete: true replaced_by: GO:0055114 consider: GO:0016491 consider: GO:0022904 [Term] id: GO:0006119 name: oxidative phosphorylation namespace: biological_process def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] subset: goslim_pir synonym: "respiratory-chain phosphorylation" EXACT [] xref: Wikipedia:Oxidative_phosphorylation is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0016310 ! phosphorylation is_a: GO:0046034 ! ATP metabolic process relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport [Term] id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006121 name: mitochondrial electron transport, succinate to ubiquinone namespace: biological_process def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] synonym: "complex II (succinate to ubiquinone)" RELATED [] synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006122 name: mitochondrial electron transport, ubiquinol to cytochrome c namespace: biological_process def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006123 name: mitochondrial electron transport, cytochrome c to oxygen namespace: biological_process def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] synonym: "complex IV (reduction of O2)" RELATED [] is_a: GO:0019646 ! aerobic electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006124 name: ferredoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732] synonym: "ferredoxin metabolism" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006125 name: obsolete thioredoxin pathway namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is not clear what it is intended to represent. synonym: "thioredoxin pathway" EXACT [] synonym: "thioredoxin reduction" NARROW [] xref: MetaCyc:THIOREDOX-PWY is_obsolete: true consider: GO:0045454 [Term] id: GO:0006126 name: obsolete other pathways of electron transport namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other pathways of electron transport" EXACT [] is_obsolete: true replaced_by: GO:0022900 [Term] id: GO:0006127 name: glycerophosphate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075] xref: MetaCyc:PWY-6118 is_a: GO:0006116 ! NADH oxidation is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process relationship: has_part GO:0004367 ! glycerol-3-phosphate dehydrogenase [NAD+] activity relationship: has_part GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0006128 name: obsolete oxidized glutathione reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. synonym: "oxidized glutathione reduction" EXACT [] is_obsolete: true consider: GO:0004362 consider: GO:0006749 consider: GO:0022900 [Term] id: GO:0006129 name: obsolete protein-disulfide reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "protein-disulfide reduction" EXACT [] synonym: "protein-disulphide reduction" EXACT [] is_obsolete: true consider: GO:0019153 consider: GO:0022900 [Term] id: GO:0006130 name: obsolete 6-phosphofructokinase reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. synonym: "6-phosphofructokinase reduction" EXACT [] is_obsolete: true consider: GO:0003872 consider: GO:0022900 [Term] id: GO:0006131 name: obsolete dihydrolipoamide reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrolipoamide reduction" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0022900 consider: GO:0051068 [Term] id: GO:0006132 name: obsolete dihydrolipoylprotein reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrolipoylprotein reduction" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0022900 [Term] id: GO:0006133 name: obsolete 5,10-methylenetetrahydrofolate oxidation namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "5,10-methylenetetrahydrofolate oxidation" EXACT [] is_obsolete: true consider: GO:0004487 consider: GO:0004488 consider: GO:0004489 consider: GO:0033738 [Term] id: GO:0006134 name: obsolete dihydrobiopterin reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrobiopterin reduction" EXACT [] is_obsolete: true consider: GO:0022900 consider: GO:0047040 consider: GO:0051066 [Term] id: GO:0006135 name: obsolete dihydropteridine reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydropteridine reduction" EXACT [] is_obsolete: true consider: GO:0004155 consider: GO:0022900 consider: GO:0051067 [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "regulation of nucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03.13 is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009117 ! nucleotide metabolic process relationship: regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006141 name: regulation of purine nucleobase metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] synonym: "regulation of purine base metabolic process" EXACT [GOC:go_curators] synonym: "regulation of purine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006144 ! purine nucleobase metabolic process relationship: regulates GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0006142 name: regulation of pyrimidine nucleobase metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] synonym: "regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "regulation of pyrimidine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006206 ! pyrimidine nucleobase metabolic process relationship: regulates GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0006143 name: obsolete purine metabolic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. synonym: "purine metabolic process" EXACT [] is_obsolete: true consider: GO:0006144 consider: GO:0006163 consider: GO:0042278 [Term] id: GO:0006144 name: purine nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] synonym: "purine base metabolic process" EXACT [GOC:go_curators] synonym: "purine base metabolism" EXACT [] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006145 name: purine nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] synonym: "purine base breakdown" EXACT [] synonym: "purine base catabolic process" EXACT [GOC:go_curators] synonym: "purine base catabolism" EXACT [] synonym: "purine base degradation" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006146 name: adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732] synonym: "adenine breakdown" EXACT [] synonym: "adenine catabolism" EXACT [] synonym: "adenine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0006147 name: guanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] synonym: "guanine breakdown" EXACT [] synonym: "guanine catabolism" EXACT [] synonym: "guanine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006148 name: inosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] synonym: "inosine breakdown" EXACT [] synonym: "inosine catabolism" EXACT [] synonym: "inosine degradation" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006149 name: deoxyinosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] synonym: "deoxyinosine breakdown" EXACT [] synonym: "deoxyinosine catabolism" EXACT [] synonym: "deoxyinosine degradation" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006150 name: hypoxanthine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295] is_a: GO:0009114 ! hypoxanthine catabolic process relationship: has_part GO:0055114 ! oxidation-reduction process [Term] id: GO:0006151 name: xanthine oxidation namespace: biological_process def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl] is_a: GO:0009115 ! xanthine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006152 name: purine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] synonym: "purine nucleoside breakdown" EXACT [] synonym: "purine nucleoside catabolism" EXACT [] synonym: "purine nucleoside degradation" EXACT [] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006153 name: obsolete purine nucleosidase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "purine nucleosidase reaction" EXACT [] is_obsolete: true replaced_by: GO:0008477 [Term] id: GO:0006154 name: adenosine catabolic process namespace: biological_process alt_id: GO:0006156 def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] synonym: "adenosine breakdown" EXACT [] synonym: "adenosine catabolism" EXACT [] synonym: "adenosine degradation" EXACT [] synonym: "adenosine phosphorolysis" RELATED [] is_a: GO:0042737 ! drug catabolic process is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006155 name: obsolete adenosine deaminase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "adenosine deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004000 [Term] id: GO:0006157 name: deoxyadenosine catabolic process namespace: biological_process alt_id: GO:0006159 def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyadenosine breakdown" EXACT [] synonym: "deoxyadenosine catabolism" EXACT [] synonym: "deoxyadenosine degradation" EXACT [] synonym: "deoxyadenosine phosphorolysis" RELATED [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006158 name: obsolete deoxyadenosine deaminase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "deoxyadenosine deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0046936 [Term] id: GO:0006161 name: deoxyguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] synonym: "deoxyguanosine breakdown" EXACT [] synonym: "deoxyguanosine catabolism" EXACT [] synonym: "deoxyguanosine degradation" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006162 name: obsolete purine/pyrimidine nucleoside diphosphate reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "purine/pyrimidine nucleoside diphosphate reduction" EXACT [] is_obsolete: true consider: GO:0004748 [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03.01 is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY xref: MIPS_funcat:01.03.01.03 is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0046939 ! nucleotide phosphorylation [Term] id: GO:0006166 name: purine ribonucleoside salvage namespace: biological_process def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] xref: MetaCyc:P121-PWY is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0006167 name: AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732] synonym: "AMP anabolism" EXACT [] synonym: "AMP biosynthesis" EXACT [] synonym: "AMP formation" EXACT [] synonym: "AMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006168 name: adenine salvage namespace: biological_process def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine salvage pathway" EXACT [] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046084 ! adenine biosynthetic process [Term] id: GO:0006169 name: adenosine salvage namespace: biological_process def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046086 ! adenosine biosynthetic process [Term] id: GO:0006170 name: dAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732] synonym: "dAMP anabolism" EXACT [] synonym: "dAMP biosynthesis" EXACT [] synonym: "dAMP formation" EXACT [] synonym: "dAMP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0006171 name: cAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] synonym: "3',5' cAMP biosynthesis" EXACT [] synonym: "3',5' cAMP biosynthetic process" EXACT [] synonym: "3',5'-cAMP biosynthesis" EXACT [] synonym: "3',5'-cAMP biosynthetic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "cAMP anabolism" EXACT [] synonym: "cAMP biosynthesis" EXACT [] synonym: "cAMP formation" EXACT [] synonym: "cAMP synthesis" EXACT [] synonym: "cyclic AMP biosynthesis" EXACT [] synonym: "cyclic AMP biosynthetic process" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046058 ! cAMP metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process [Term] id: GO:0006172 name: ADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] synonym: "ADP anabolism" EXACT [] synonym: "ADP biosynthesis" EXACT [] synonym: "ADP formation" EXACT [] synonym: "ADP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006173 name: dADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732] synonym: "dADP anabolism" EXACT [] synonym: "dADP biosynthesis" EXACT [] synonym: "dADP formation" EXACT [] synonym: "dADP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006174 name: dADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006175 name: dATP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732] synonym: "dATP anabolism" EXACT [] synonym: "dATP biosynthesis" EXACT [] synonym: "dATP formation" EXACT [] synonym: "dATP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0006176 name: dATP biosynthetic process from ADP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732] synonym: "dATP anabolism from ADP" EXACT [] synonym: "dATP formation from ADP" EXACT [] synonym: "dATP synthesis from ADP" EXACT [] is_a: GO:0006175 ! dATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006177 name: GMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] synonym: "GMP anabolism" EXACT [] synonym: "GMP biosynthesis" EXACT [] synonym: "GMP formation" EXACT [] synonym: "GMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046037 ! GMP metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0006178 name: guanine salvage namespace: biological_process def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006179 name: guanosine salvage namespace: biological_process def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0006180 name: deoxyguanosine salvage namespace: biological_process def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043098 ! purine deoxyribonucleoside salvage [Term] id: GO:0006181 name: dGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732] synonym: "dGMP anabolism" EXACT [] synonym: "dGMP biosynthesis" EXACT [] synonym: "dGMP formation" EXACT [] synonym: "dGMP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0006182 name: cGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] synonym: "cGMP anabolism" EXACT [] synonym: "cGMP biosynthesis" EXACT [] synonym: "cGMP formation" EXACT [] synonym: "cGMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046068 ! cGMP metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process [Term] id: GO:0006183 name: GTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] synonym: "GTP anabolism" EXACT [] synonym: "GTP biosynthesis" EXACT [] synonym: "GTP formation" EXACT [] synonym: "GTP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046039 ! GTP metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0006184 name: obsolete GTP catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "GTP breakdown" EXACT [] synonym: "GTP catabolism" EXACT [] synonym: "GTP degradation" EXACT [] synonym: "GTP hydrolysis" NARROW [] is_obsolete: true consider: GO:0003924 [Term] id: GO:0006185 name: dGDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732] synonym: "dGDP anabolism" EXACT [] synonym: "dGDP biosynthesis" EXACT [] synonym: "dGDP formation" EXACT [] synonym: "dGDP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006186 name: dGDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006187 name: dGTP biosynthetic process from dGDP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732] synonym: "dGTP anabolism from dGDP" EXACT [] synonym: "dGTP formation from dGDP" EXACT [] synonym: "dGTP synthesis from dGDP" EXACT [] is_a: GO:0046066 ! dGDP metabolic process is_a: GO:0046071 ! dGTP biosynthetic process [Term] id: GO:0006188 name: IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] synonym: "IMP anabolism" EXACT [] synonym: "IMP biosynthesis" EXACT [] synonym: "IMP formation" EXACT [] synonym: "IMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006189 name: 'de novo' IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] synonym: "'de novo' IMP anabolism" EXACT [] synonym: "'de novo' IMP biosynthesis" EXACT [] synonym: "'de novo' IMP formation" EXACT [] synonym: "'de novo' IMP synthesis" EXACT [] synonym: "'de novo' purine biosynthesis" BROAD [] synonym: "'de novo' purine biosynthetic process" BROAD [] is_a: GO:0006188 ! IMP biosynthetic process [Term] id: GO:0006190 name: inosine salvage namespace: biological_process def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046103 ! inosine biosynthetic process [Term] id: GO:0006191 name: deoxyinosine salvage namespace: biological_process def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043098 ! purine deoxyribonucleoside salvage is_a: GO:0046095 ! deoxyinosine biosynthetic process [Term] id: GO:0006192 name: IDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0006193 name: ITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732] synonym: "ITP breakdown" EXACT [] synonym: "ITP catabolism" EXACT [] synonym: "ITP degradation" EXACT [] synonym: "ITP hydrolysis" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0006194 name: dIDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process [Term] id: GO:0006195 name: purine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide breakdown" EXACT [] synonym: "purine nucleotide catabolism" EXACT [] synonym: "purine nucleotide degradation" EXACT [] xref: MIPS_funcat:01.03.01.01 is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006196 name: AMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732] synonym: "AMP breakdown" EXACT [] synonym: "AMP catabolism" EXACT [] synonym: "AMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006197 name: obsolete adenylate deaminase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "adenylate deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003876 [Term] id: GO:0006198 name: cAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] synonym: "3',5' cAMP catabolic process" EXACT [] synonym: "3',5' cAMP catabolism" EXACT [] synonym: "3',5'-cAMP catabolic process" EXACT [] synonym: "3',5'-cAMP catabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "cAMP breakdown" EXACT [] synonym: "cAMP catabolism" EXACT [] synonym: "cAMP degradation" EXACT [] synonym: "cyclic AMP catabolic process" EXACT [] synonym: "cyclic AMP catabolism" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006199 name: obsolete ADP reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "ADP reduction" EXACT [] is_obsolete: true consider: GO:0051061 [Term] id: GO:0006200 name: obsolete ATP catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "ATP breakdown" EXACT [] synonym: "ATP catabolism" EXACT [] synonym: "ATP degradation" EXACT [] synonym: "ATP hydrolysis" NARROW [] xref: Wikipedia:ATP_hydrolysis is_obsolete: true consider: GO:0016887 [Term] id: GO:0006201 name: GMP catabolic process to IMP namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732] synonym: "GMP breakdown to IMP" EXACT [] synonym: "GMP degradation to IMP" EXACT [] is_a: GO:0006188 ! IMP biosynthetic process is_a: GO:0046038 ! GMP catabolic process [Term] id: GO:0006202 name: GMP catabolic process to guanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732] synonym: "GMP breakdown to guanine" EXACT [] synonym: "GMP degradation to guanine" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006203 name: dGTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732] synonym: "dGTP breakdown" EXACT [] synonym: "dGTP catabolism" EXACT [] synonym: "dGTP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0006204 name: IMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732] synonym: "IMP breakdown" EXACT [] synonym: "IMP catabolism" EXACT [] synonym: "IMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006205 name: obsolete pyrimidine metabolic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. synonym: "pyrimidine metabolic process" EXACT [] is_obsolete: true consider: GO:0006206 consider: GO:0006213 consider: GO:0006220 [Term] id: GO:0006206 name: pyrimidine nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] synonym: "pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "pyrimidine base metabolism" EXACT [] synonym: "pyrimidine metabolic process" RELATED [] synonym: "pyrimidine metabolism" RELATED [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006207 name: 'de novo' pyrimidine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] synonym: "'de novo' pyrimidine base anabolism" EXACT [] synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] synonym: "'de novo' pyrimidine base biosynthetic process" EXACT [GOC:go_curators] synonym: "'de novo' pyrimidine base formation" EXACT [] synonym: "'de novo' pyrimidine base synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process [Term] id: GO:0006208 name: pyrimidine nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] synonym: "pyrimidine base breakdown" EXACT [] synonym: "pyrimidine base catabolic process" EXACT [GOC:go_curators] synonym: "pyrimidine base catabolism" EXACT [] synonym: "pyrimidine base degradation" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006209 name: cytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] synonym: "cytosine breakdown" EXACT [] synonym: "cytosine catabolism" EXACT [] synonym: "cytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0006210 name: thymine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] synonym: "thymine breakdown" EXACT [] synonym: "thymine catabolism" EXACT [] synonym: "thymine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0006211 name: 5-methylcytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] synonym: "5-methylcytosine breakdown" EXACT [] synonym: "5-methylcytosine catabolism" EXACT [] synonym: "5-methylcytosine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019857 ! 5-methylcytosine metabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006212 name: uracil catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil breakdown" EXACT [] synonym: "uracil catabolism" EXACT [] synonym: "uracil degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019860 ! uracil metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006213 name: pyrimidine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006214 name: thymidine catabolic process namespace: biological_process alt_id: GO:0006215 def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] synonym: "deoxyribosylthymine catabolic process" EXACT [] synonym: "deoxyribosylthymine catabolism" EXACT [] synonym: "thymidine breakdown" EXACT [] synonym: "thymidine catabolism" EXACT [] synonym: "thymidine degradation" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006216 name: cytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] synonym: "cytidine breakdown" EXACT [] synonym: "cytidine catabolism" EXACT [] synonym: "cytidine degradation" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006217 name: deoxycytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxycytidine breakdown" EXACT [] synonym: "deoxycytidine catabolism" EXACT [] synonym: "deoxycytidine degradation" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006218 name: uridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] synonym: "uridine breakdown" EXACT [] synonym: "uridine catabolism" EXACT [] synonym: "uridine degradation" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006219 name: deoxyuridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyuridine breakdown" EXACT [] synonym: "deoxyuridine catabolism" EXACT [] synonym: "deoxyuridine degradation" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006220 name: pyrimidine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03.04 is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006221 name: pyrimidine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleotide anabolism" EXACT [] synonym: "pyrimidine nucleotide biosynthesis" EXACT [] synonym: "pyrimidine nucleotide formation" EXACT [] synonym: "pyrimidine nucleotide synthesis" EXACT [] xref: MIPS_funcat:01.03.04.03 is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0006222 name: UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] synonym: "UMP anabolism" EXACT [] synonym: "UMP biosynthesis" EXACT [] synonym: "UMP formation" EXACT [] synonym: "UMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0006223 name: uracil salvage namespace: biological_process def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] is_a: GO:0043100 ! pyrimidine nucleobase salvage is_a: GO:0046107 ! uracil biosynthetic process [Term] id: GO:0006224 name: obsolete uridine kinase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "uridine kinase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004849 [Term] id: GO:0006225 name: UDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] synonym: "UDP anabolism" EXACT [] synonym: "UDP biosynthesis" EXACT [] synonym: "UDP formation" EXACT [] synonym: "UDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006226 name: dUMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732] synonym: "dUMP anabolism" EXACT [] synonym: "dUMP biosynthesis" EXACT [] synonym: "dUMP formation" EXACT [] synonym: "dUMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0006227 name: dUDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732] synonym: "dUDP anabolism" EXACT [] synonym: "dUDP biosynthesis" EXACT [] synonym: "dUDP formation" EXACT [] synonym: "dUDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006228 name: UTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] synonym: "UTP anabolism" EXACT [] synonym: "UTP biosynthesis" EXACT [] synonym: "UTP formation" EXACT [] synonym: "UTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0006229 name: dUTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732] synonym: "dUTP anabolism" EXACT [] synonym: "dUTP biosynthesis" EXACT [] synonym: "dUTP formation" EXACT [] synonym: "dUTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0006230 name: TMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732] synonym: "TMP anabolism" EXACT [] synonym: "TMP biosynthesis" EXACT [] synonym: "TMP formation" EXACT [] synonym: "TMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0006231 name: dTMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] synonym: "dTMP anabolism" EXACT [] synonym: "dTMP biosynthesis" EXACT [] synonym: "dTMP formation" EXACT [] synonym: "dTMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0006232 name: TDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732] synonym: "TDP anabolism" EXACT [] synonym: "TDP biosynthesis" EXACT [] synonym: "TDP formation" EXACT [] synonym: "TDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006233 name: dTDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732] synonym: "dTDP anabolism" EXACT [] synonym: "dTDP biosynthesis" EXACT [] synonym: "dTDP formation" EXACT [] synonym: "dTDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006234 name: TTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732] synonym: "TTP anabolism" EXACT [] synonym: "TTP biosynthesis" EXACT [] synonym: "TTP formation" EXACT [] synonym: "TTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0006235 name: dTTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732] synonym: "dTTP anabolism" EXACT [] synonym: "dTTP biosynthesis" EXACT [] synonym: "dTTP formation" EXACT [] synonym: "dTTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0006236 name: cytidine salvage namespace: biological_process def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046088 ! cytidine biosynthetic process [Term] id: GO:0006237 name: deoxycytidine salvage namespace: biological_process def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage is_a: GO:0046093 ! deoxycytidine biosynthetic process [Term] id: GO:0006238 name: CMP salvage namespace: biological_process def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "cytidine monophosphate salvage" EXACT [] is_a: GO:0009224 ! CMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0006239 name: dCMP salvage namespace: biological_process def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] synonym: "deoxycytidine monophosphate salvage" EXACT [] is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage is_a: GO:0046064 ! dCMP biosynthetic process [Term] id: GO:0006240 name: dCDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] synonym: "dCDP anabolism" EXACT [] synonym: "dCDP biosynthesis" EXACT [] synonym: "dCDP formation" EXACT [] synonym: "dCDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006241 name: CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] synonym: "CTP anabolism" EXACT [] synonym: "CTP biosynthesis" EXACT [] synonym: "CTP formation" EXACT [] synonym: "CTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006242 name: dCTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] synonym: "dCTP anabolism" EXACT [] synonym: "dCTP biosynthesis" EXACT [] synonym: "dCTP formation" EXACT [] synonym: "dCTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006244 name: pyrimidine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleotide breakdown" EXACT [] synonym: "pyrimidine nucleotide catabolism" EXACT [] synonym: "pyrimidine nucleotide degradation" EXACT [] xref: MIPS_funcat:01.03.04.01 is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006245 name: TDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732] synonym: "TDP breakdown" EXACT [] synonym: "TDP catabolism" EXACT [] synonym: "TDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006246 name: dTDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732] synonym: "dTDP breakdown" EXACT [] synonym: "dTDP catabolism" EXACT [] synonym: "dTDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006247 name: obsolete TTP reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "TTP reduction" EXACT [] is_obsolete: true consider: GO:0051064 [Term] id: GO:0006248 name: CMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732] synonym: "CMP breakdown" EXACT [] synonym: "CMP catabolism" EXACT [] synonym: "CMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0006249 name: dCMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732] synonym: "dCMP breakdown" EXACT [] synonym: "dCMP catabolism" EXACT [] synonym: "dCMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0006250 name: obsolete CDP reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "CDP reduction" EXACT [] is_obsolete: true consider: GO:0051063 [Term] id: GO:0006251 name: dCDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] synonym: "dCDP breakdown" EXACT [] synonym: "dCDP catabolism" EXACT [] synonym: "dCDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006252 name: obsolete CTP reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "CTP reduction" EXACT [] is_obsolete: true consider: GO:0051065 [Term] id: GO:0006253 name: dCTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] synonym: "dCTP breakdown" EXACT [] synonym: "dCTP catabolism" EXACT [] synonym: "dCTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006254 name: CTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] synonym: "CTP breakdown" EXACT [] synonym: "CTP catabolism" EXACT [] synonym: "CTP degradation" EXACT [] synonym: "CTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006255 name: obsolete UDP reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "UDP reduction" EXACT [] is_obsolete: true consider: GO:0051062 [Term] id: GO:0006256 name: UDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] synonym: "UDP breakdown" EXACT [] synonym: "UDP catabolism" EXACT [] synonym: "UDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006257 name: dUDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732] synonym: "dUDP breakdown" EXACT [] synonym: "dUDP catabolism" EXACT [] synonym: "dUDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006258 name: UDP-glucose catabolic process namespace: biological_process alt_id: GO:0019691 def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucose breakdown" EXACT [] synonym: "UDP-glucose catabolism" EXACT [] synonym: "UDP-glucose conversion" RELATED [] synonym: "UDP-glucose degradation" EXACT [] is_a: GO:0006011 ! UDP-glucose metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] xref: MIPS_funcat:10 xref: MIPS_funcat:10.01 is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006260 name: DNA replication namespace: biological_process alt_id: GO:0055133 def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_drosophila subset: goslim_pir subset: goslim_pombe subset: goslim_yeast xref: MIPS_funcat:10.01.03 xref: Wikipedia:DNA_replication is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: has_part GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006261 name: DNA-dependent DNA replication namespace: biological_process alt_id: GO:0006262 alt_id: GO:0006263 def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] is_a: GO:0006260 ! DNA replication [Term] id: GO:0006264 name: mitochondrial DNA replication namespace: biological_process def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] synonym: "mitochondrial DNA synthesis" RELATED [] synonym: "mtDNA replication" EXACT [] synonym: "mtDNA synthesis" RELATED [] synonym: "replication of mitochondrial DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication intersection_of: GO:0006260 ! DNA replication intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0006265 name: DNA topological change namespace: biological_process def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. synonym: "DNA underwinding" NARROW [] xref: MIPS_funcat:10.01.09.05 is_a: GO:0006259 ! DNA metabolic process is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006266 name: DNA ligation namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006267 name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle] synonym: "nuclear pre-replicative complex assembly" EXACT [] synonym: "pre-RC complex assembly" BROAD [] synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-replicative complex formation" BROAD [] xref: MIPS_funcat:10.01.03.03 is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication [Term] id: GO:0006268 name: DNA unwinding involved in DNA replication namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb] synonym: "DNA unwinding factor" RELATED [] is_a: GO:0032508 ! DNA duplex unwinding intersection_of: GO:0032508 ! DNA duplex unwinding intersection_of: part_of GO:0006261 ! DNA-dependent DNA replication relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006269 name: DNA replication, synthesis of RNA primer namespace: biological_process def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] synonym: "replication priming" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006270 name: DNA replication initiation namespace: biological_process alt_id: GO:0042024 def: "The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate." [ISBN:071673706X, ISBN:0815316194, PMID:28209641] synonym: "DNA endoreduplication initiation" NARROW [] synonym: "DNA re-replication initiation" NARROW [] synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006271 name: DNA strand elongation involved in DNA replication namespace: biological_process def: "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 synonym: "DNA replication elongation" EXACT [] synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] xref: MIPS_funcat:10.01.03.05 is_a: GO:0022616 ! DNA strand elongation intersection_of: GO:0022616 ! DNA strand elongation intersection_of: part_of GO:0006260 ! DNA replication relationship: has_part GO:0090592 ! DNA synthesis involved in DNA replication relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006272 name: leading strand elongation namespace: biological_process def: "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006271 ! DNA strand elongation involved in DNA replication relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer relationship: has_part GO:0043137 ! DNA replication, removal of RNA primer [Term] id: GO:0006273 name: lagging strand elongation namespace: biological_process def: "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006271 ! DNA strand elongation involved in DNA replication relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer relationship: has_part GO:0043137 ! DNA replication, removal of RNA primer [Term] id: GO:0006274 name: DNA replication termination namespace: biological_process def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006275 name: regulation of DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006260 ! DNA replication relationship: regulates GO:0006260 ! DNA replication [Term] id: GO:0006276 name: plasmid maintenance namespace: biological_process def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0006277 name: DNA amplification namespace: biological_process def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006278 name: RNA-dependent DNA biosynthetic process namespace: biological_process def: "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006279 name: premeiotic DNA replication namespace: biological_process alt_id: GO:1902968 def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie] synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "meiotic cell cycle DNA replication" EXACT [] synonym: "meiotic DNA replication" RELATED [GOC:mah] synonym: "meiotic DNA synthesis" RELATED [GOC:mah] synonym: "meiotic nuclear cell cycle DNA replication" EXACT [] synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT [] synonym: "premeiotic DNA synthesis" RELATED [GOC:mah] is_a: GO:0033260 ! nuclear DNA replication is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0033260 ! nuclear DNA replication intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0006280 name: obsolete mutagenesis namespace: biological_process def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732] comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. synonym: "mutagenesis" EXACT [] is_obsolete: true consider: GO:0006281 consider: GO:0051276 [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_drosophila subset: goslim_pir subset: goslim_pombe subset: goslim_yeast xref: MIPS_funcat:10.01.05 xref: MIPS_funcat:10.01.05.01 xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! cellular response to DNA damage stimulus [Term] id: GO:0006282 name: regulation of DNA repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006281 ! DNA repair relationship: regulates GO:0006281 ! DNA repair [Term] id: GO:0006283 name: transcription-coupled nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] synonym: "TC-NER" EXACT [PMID:10197977] synonym: "TCR" RELATED [GOC:vw, PMID:18794354] synonym: "transcription-coupled NER" EXACT [GOC:mah] synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354] is_a: GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006284 name: base-excision repair namespace: biological_process def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] synonym: "BER" EXACT [] xref: Wikipedia:Base_excision_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006285 name: base-excision repair, AP site formation namespace: biological_process def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006286 name: base-excision repair, base-free sugar-phosphate removal namespace: biological_process def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0098502 ! DNA dephosphorylation relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006287 name: base-excision repair, gap-filling namespace: biological_process def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006288 name: base-excision repair, DNA ligation namespace: biological_process def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] is_a: GO:0051103 ! DNA ligation involved in DNA repair intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0006284 ! base-excision repair relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006289 name: nucleotide-excision repair namespace: biological_process alt_id: GO:0045001 def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. synonym: "intrastrand cross-link repair" RELATED [] synonym: "NER" EXACT [] synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] is_a: GO:0006281 ! DNA repair [Term] id: GO:0006290 name: pyrimidine dimer repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] is_a: GO:0006281 ! DNA repair [Term] id: GO:0006291 name: obsolete pyrimidine-dimer repair, DNA damage excision namespace: biological_process def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] comment: This term was made obsolete because this process can be subdivided into multiple processes. synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] is_obsolete: true consider: GO:0006289 [Term] id: GO:0006292 name: obsolete pyrimidine-dimer repair, DNA damage recognition namespace: biological_process def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] comment: This term was made obsolete because it is a substrate specific DNA repair process. synonym: "pyrimidine-dimer repair, DNA damage recognition" EXACT [] is_obsolete: true consider: GO:0000715 consider: GO:0000716 [Term] id: GO:0006293 name: nucleotide-excision repair, preincision complex stabilization namespace: biological_process def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006294 name: nucleotide-excision repair, preincision complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006295 name: nucleotide-excision repair, DNA incision, 3'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006296 name: nucleotide-excision repair, DNA incision, 5'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006297 name: nucleotide-excision repair, DNA gap filling namespace: biological_process def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006298 name: mismatch repair namespace: biological_process alt_id: GO:0006300 def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] synonym: "long patch mismatch repair system" NARROW [] synonym: "mismatch repair, MutL-like pathway" RELATED [] synonym: "MMR" EXACT [] synonym: "MutS/MutL/MutH pathway" RELATED [] xref: Wikipedia:DNA_mismatch_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006299 name: obsolete short patch mismatch repair system namespace: biological_process def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. synonym: "short patch mismatch repair system" EXACT [] is_obsolete: true consider: GO:0006284 consider: GO:0006289 [Term] id: GO:0006301 name: postreplication repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] synonym: "postreplication DNA repair" EXACT [] xref: Wikipedia:Postreplication_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006302 name: double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. is_a: GO:0006281 ! DNA repair [Term] id: GO:0006303 name: double-strand break repair via nonhomologous end joining namespace: biological_process def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] synonym: "NHEJ" EXACT [] is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0006304 name: DNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] subset: goslim_pir xref: MIPS_funcat:10.01.09 is_a: GO:0006259 ! DNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0006305 name: DNA alkylation namespace: biological_process def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] is_a: GO:0006304 ! DNA modification [Term] id: GO:0006306 name: DNA methylation namespace: biological_process def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] xref: MIPS_funcat:10.01.09.01 xref: Wikipedia:DNA_methylation is_a: GO:0006305 ! DNA alkylation is_a: GO:0043414 ! macromolecule methylation is_a: GO:0044728 ! DNA methylation or demethylation [Term] id: GO:0006307 name: DNA dealkylation involved in DNA repair namespace: biological_process def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] is_a: GO:0035510 ! DNA dealkylation intersection_of: GO:0035510 ! DNA dealkylation intersection_of: part_of GO:0006281 ! DNA repair relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] xref: MIPS_funcat:01.03.16 xref: MIPS_funcat:01.03.16.03 is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process relationship: has_part GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0006309 name: apoptotic DNA fragmentation namespace: biological_process alt_id: GO:0008178 def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] is_a: GO:0000737 ! DNA catabolic process, endonucleolytic intersection_of: GO:0000737 ! DNA catabolic process, endonucleolytic intersection_of: part_of GO:0030262 ! apoptotic nuclear changes relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pombe subset: goslim_yeast xref: MIPS_funcat:10.01.05 xref: MIPS_funcat:10.01.05.03 is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006311 name: meiotic gene conversion namespace: biological_process def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] synonym: "gene conversion without reciprocal crossover" EXACT [] is_a: GO:0035822 ! gene conversion is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0006312 name: mitotic recombination namespace: biological_process def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] xref: MIPS_funcat:10.01.05.03.03 xref: Wikipedia:Mitotic_crossover is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006313 name: transposition, DNA-mediated namespace: biological_process alt_id: GO:0006317 alt_id: GO:0006318 def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] synonym: "Class II transposition" EXACT [] synonym: "DNA transposition" EXACT [GOC:dph] synonym: "P-element excision" NARROW [] synonym: "P-element transposition" NARROW [] synonym: "Tc1/mariner transposition" NARROW [] synonym: "Tc3 transposition" NARROW [] is_a: GO:0006310 ! DNA recombination is_a: GO:0032196 ! transposition [Term] id: GO:0006314 name: intron homing namespace: biological_process def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006315 name: homing of group II introns namespace: biological_process def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] is_a: GO:0006314 ! intron homing [Term] id: GO:0006316 name: movement of group I intron namespace: biological_process def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] is_a: GO:0006314 ! intron homing [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA condensation" EXACT [] synonym: "DNA organisation" EXACT [] synonym: "DNA organization" EXACT [] is_a: GO:0071103 ! DNA conformation change relationship: has_part GO:0008301 ! DNA binding, bending [Term] id: GO:0006324 name: obsolete S phase-specific histone modification namespace: biological_process def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] comment: This term was made obsolete because histone modification already exists and the phase specificity is better captured as an annotation extension. synonym: "S phase-specific histone modification" EXACT [] synonym: "S-phase-specific histone modification" EXACT [] is_obsolete: true consider: GO:0016570 [Term] id: GO:0006325 name: chromatin organization namespace: biological_process alt_id: GO:0016568 def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah, GOC:vw, PMID:20404130] subset: goslim_pombe subset: goslim_yeast synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0051276 ! chromosome organization [Term] id: GO:0006326 name: obsolete bent DNA binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "bent DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003681 [Term] id: GO:0006327 name: obsolete random coil binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "random coil binding" EXACT [] is_obsolete: true consider: GO:0003695 [Term] id: GO:0006328 name: obsolete AT binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "AT binding" EXACT [] is_obsolete: true replaced_by: GO:0003680 [Term] id: GO:0006329 name: obsolete satellite DNA binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "satellite DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003696 [Term] id: GO:0006330 name: obsolete single-stranded DNA binding namespace: biological_process alt_id: GO:0006331 alt_id: GO:0006332 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "single-stranded DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003697 [Term] id: GO:0006333 name: chromatin assembly or disassembly namespace: biological_process def: "The formation or destruction of chromatin structures." [GOC:mah] synonym: "chromatin assembly/disassembly" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006334 name: nucleosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] synonym: "histone chaperone" RELATED [GOC:vw] synonym: "nucleosome modeling" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0031497 ! chromatin assembly [Term] id: GO:0006335 name: DNA replication-dependent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0006336 name: DNA replication-independent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] synonym: "transcription-coupled nucleosome assembly" EXACT [] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0006337 name: nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] is_a: GO:0032986 ! protein-DNA complex disassembly is_a: GO:0034728 ! nucleosome organization relationship: part_of GO:0031498 ! chromatin disassembly [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, GOC:vw, PMID:12697820] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006339 name: obsolete positive regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "positive regulation of transcription of homeotic gene (trithorax group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006340 name: obsolete negative regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "negative regulation of transcription of homeotic gene (Polycomb group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006341 name: obsolete chromatin insulator sequence binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "chromatin insulator sequence binding" EXACT [] is_obsolete: true replaced_by: GO:0043035 [Term] id: GO:0006342 name: chromatin silencing namespace: biological_process alt_id: GO:0016440 def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "heterochromatic silencing" RELATED [] synonym: "TGS" EXACT [] synonym: "transcriptional gene silencing" EXACT [] is_a: GO:0016458 ! gene silencing is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0097549 ! chromatin organization involved in negative regulation of transcription [Term] id: GO:0006343 name: establishment of chromatin silencing namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah] synonym: "establishment of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006344 name: maintenance of chromatin silencing namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006346 name: methylation-dependent chromatin silencing namespace: biological_process def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] synonym: "methylation-dependent heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0016569 ! covalent chromatin modification intersection_of: GO:0006342 ! chromatin silencing intersection_of: has_part GO:0006306 ! DNA methylation relationship: has_part GO:0006306 ! DNA methylation [Term] id: GO:0006348 name: chromatin silencing at telomere namespace: biological_process def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] synonym: "heterochromatic silencing at telomere" EXACT [] synonym: "telomere chromatin silencing" EXACT [GOC:mah] synonym: "Telomere Position Effect" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:21847107] synonym: "telomeric silencing" EXACT [GOC:bf] is_a: GO:0006342 ! chromatin silencing intersection_of: GO:0006342 ! chromatin silencing intersection_of: occurs_in GO:0000781 ! chromosome, telomeric region relationship: occurs_in GO:0000781 ! chromosome, telomeric region [Term] id: GO:0006349 name: regulation of gene expression by genetic imprinting namespace: biological_process def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732, PMID:11498578] synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah] xref: MIPS_funcat:10.01.09.07 xref: Wikipedia:Genomic_imprinting is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0071514 ! genetic imprinting intersection_of: GO:0071514 ! genetic imprinting intersection_of: regulates GO:0010467 ! gene expression [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: MIPS_funcat:11.02 xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0097659 ! nucleic acid-templated transcription relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006352 name: DNA-templated transcription, initiation namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. subset: goslim_yeast synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT [] synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription initiation factor activity" RELATED [] synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2] xref: MIPS_funcat:11.02.03.01.01 is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006353 name: DNA-templated transcription, termination namespace: biological_process def: "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] subset: goslim_yeast synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription termination factor activity" RELATED [] synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2] synonym: "transcriptional complex disassembly" BROAD [] xref: MIPS_funcat:11.02.03.01.07 is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006354 name: DNA-templated transcription, elongation namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] subset: goslim_pir subset: goslim_yeast synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "RNA elongation" BROAD [] synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "transcriptional elongation, DNA-dependent" EXACT [] xref: MIPS_funcat:11.02.03.01.04 is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006355 name: regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903506 ! regulation of nucleic acid-templated transcription is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006351 ! transcription, DNA-templated relationship: regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006356 name: regulation of transcription by RNA polymerase I namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] synonym: "regulation of transcription from Pol I promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006360 ! transcription by RNA polymerase I relationship: regulates GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006357 name: regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II relationship: regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006359 name: regulation of transcription by RNA polymerase III namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III." [GOC:go_curators] synonym: "regulation of transcription from Pol III promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006383 ! transcription by RNA polymerase III relationship: regulates GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006360 name: transcription by RNA polymerase I namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 subset: goslim_yeast synonym: "RNA polymerase I transcription factor activity" RELATED [] synonym: "transcription from Pol I promoter" EXACT [] synonym: "transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006361 name: transcription initiation from RNA polymerase I promoter namespace: biological_process alt_id: GO:0001180 def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol I promoter" EXACT [] synonym: "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006360 ! transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-15T03:45:49Z [Term] id: GO:0006362 name: transcription elongation from RNA polymerase I promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol I promoter" EXACT [] synonym: "RNA polymerase I transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006363 name: termination of RNA polymerase I transcription namespace: biological_process alt_id: GO:0001185 alt_id: GO:0019223 def: "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922] synonym: "RNA polymerase I transcription termination" EXACT [] synonym: "RNA polymerase I transcription termination factor activity" RELATED [] synonym: "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript" NARROW [] synonym: "transcription termination from Pol I promoter" EXACT [] synonym: "transcription termination from RNA polymerase I promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006360 ! transcription by RNA polymerase I created_by: kchris creation_date: 2011-08-15T04:07:43Z [Term] id: GO:0006364 name: rRNA processing namespace: biological_process alt_id: GO:0006365 def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] subset: goslim_yeast synonym: "35S primary transcript processing" NARROW [] xref: MIPS_funcat:11.04.01 is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006366 name: transcription by RNA polymerase II namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 subset: goslim_yeast synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "RNA polymerase II transcription factor activity" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] synonym: "transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006367 name: transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol II promoter" EXACT [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006368 name: transcription elongation from RNA polymerase II promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol II promoter" EXACT [] synonym: "RNA polymerase II transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006369 name: termination of RNA polymerase II transcription namespace: biological_process alt_id: GO:0019224 def: "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah, GOC:txnOH] synonym: "RNA 3'-end formation by RNA polymerase II" EXACT [] synonym: "RNA polymerase II transcription termination" EXACT [] synonym: "RNA polymerase II transcription termination factor activity" RELATED [] synonym: "transcription termination from Pol II promoter" EXACT [] synonym: "transcription termination from RNA polymerase II promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006370 name: 7-methylguanosine mRNA capping namespace: biological_process def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] synonym: "5' end capping" BROAD [] synonym: "5' mRNA capping" EXACT [] synonym: "5'-end mRNA processing" EXACT [] synonym: "5'-end processing" BROAD [] synonym: "mRNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] xref: MIPS_funcat:11.04.03.03 is_a: GO:0006397 ! mRNA processing is_a: GO:0009452 ! 7-methylguanosine RNA capping [Term] id: GO:0006371 name: obsolete mRNA splicing namespace: biological_process def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732] comment: This term was made obsolete because it represents several different processes. synonym: "mRNA splicing" EXACT [] is_obsolete: true consider: GO:0000372 consider: GO:0000373 consider: GO:0000374 consider: GO:0000394 consider: GO:0000398 [Term] id: GO:0006372 name: obsolete lariat formation, 5'-splice site cleavage namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. synonym: "lariat formation, 5'-splice site cleavage" EXACT [] is_obsolete: true consider: GO:0000350 consider: GO:0000386 [Term] id: GO:0006373 name: obsolete 3'-splice site cleavage, exon ligation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. synonym: "3'-splice site cleavage, exon ligation" EXACT [] is_obsolete: true consider: GO:0000386 consider: GO:0000388 consider: GO:0000393 [Term] id: GO:0006376 name: mRNA splice site selection namespace: biological_process def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly [Term] id: GO:0006377 name: obsolete MATa1 (A1) pre-mRNA splicing namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. synonym: "MATa1 (A1) pre-mRNA splicing" EXACT [] is_obsolete: true consider: GO:0000244 [Term] id: GO:0006378 name: mRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] synonym: "mRNA polyadenylylation" EXACT [] is_a: GO:0031124 ! mRNA 3'-end processing is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0006379 name: mRNA cleavage namespace: biological_process def: "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] synonym: "cleavage stimulation factor activity" RELATED [] is_a: GO:0016071 ! mRNA metabolic process is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis [Term] id: GO:0006380 name: obsolete poly-A binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "poly-A binding" EXACT [] is_obsolete: true consider: GO:0008143 [Term] id: GO:0006382 name: adenosine to inosine editing namespace: biological_process def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0006383 name: transcription by RNA polymerase III namespace: biological_process alt_id: GO:0001009 alt_id: GO:0001035 alt_id: GO:0001041 def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854\nMerged terms as requested in https://github.com/geneontology/go-ontology/issues/9617 subset: goslim_yeast synonym: "RNA polymerase III transcription factor activity" RELATED [] synonym: "transcription from a RNA polymerase III hybrid type promoter" NARROW [] synonym: "transcription from Pol III promoter" EXACT [] synonym: "transcription from RNA polymerase III promoter" EXACT [] synonym: "transcription from RNA polymerase III type 2 promoter" NARROW [] synonym: "transcription from RNA polymerase III type 3 promoter" NARROW [] synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW [] synonym: "U6 snRNA transcription (mammalian)" NARROW [] is_a: GO:0006351 ! transcription, DNA-templated created_by: kchris creation_date: 2010-08-18T06:37:56Z [Term] id: GO:0006384 name: transcription initiation from RNA polymerase III promoter namespace: biological_process alt_id: GO:0001022 alt_id: GO:0001023 alt_id: GO:0001024 alt_id: GO:0001036 def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol III promoter" EXACT [] synonym: "transcription initiation from RNA polymerase III hybrid type promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 1 promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 2 promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 3 promoter" NARROW [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006383 ! transcription by RNA polymerase III created_by: kchris creation_date: 2010-08-19T04:33:52Z [Term] id: GO:0006385 name: transcription elongation from RNA polymerase III promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol III promoter" EXACT [] synonym: "RNA polymerase III transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006386 name: termination of RNA polymerase III transcription namespace: biological_process alt_id: GO:0019225 def: "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] synonym: "RNA polymerase III transcription termination" EXACT [] synonym: "RNA polymerase III transcription termination factor activity" RELATED [] synonym: "transcription termination from Pol III promoter" EXACT [] synonym: "transcription termination from RNA polymerase III promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006387 name: obsolete snRNA capping namespace: biological_process def: "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah] comment: This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. synonym: "snRNA capping" EXACT [] is_obsolete: true consider: GO:0036261 [Term] id: GO:0006388 name: tRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. synonym: "tRNA-Y splicing" NARROW [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0008033 ! tRNA processing [Term] id: GO:0006389 name: obsolete tRNA-Y splicing namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. synonym: "tRNA-Y splicing" EXACT [] is_obsolete: true consider: GO:0006388 [Term] id: GO:0006390 name: mitochondrial transcription namespace: biological_process def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006351 ! transcription, DNA-templated intersection_of: GO:0006351 ! transcription, DNA-templated intersection_of: occurs_in GO:0005739 ! mitochondrion intersection_of: part_of GO:0140053 ! mitochondrial gene expression relationship: part_of GO:0140053 ! mitochondrial gene expression [Term] id: GO:0006391 name: transcription initiation from mitochondrial promoter namespace: biological_process def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006392 name: transcription elongation from mitochondrial promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006393 name: termination of mitochondrial transcription namespace: biological_process def: "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] synonym: "mitochondrial transcription termination" EXACT [] synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006353 ! DNA-templated transcription, termination intersection_of: GO:0006353 ! DNA-templated transcription, termination intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006396 name: RNA processing namespace: biological_process alt_id: GO:0006394 def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] subset: goslim_pir xref: MIPS_funcat:11.04 xref: Wikipedia:Post-transcriptional_modification is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "mRNA maturation" RELATED [] xref: MIPS_funcat:11.04.03 is_a: GO:0006396 ! RNA processing is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006398 name: mRNA 3'-end processing by stem-loop binding and cleavage namespace: biological_process def: "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288] synonym: "histone mRNA 3' end processing" NARROW [] is_a: GO:0008334 ! histone mRNA metabolic process is_a: GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "tRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0006400 name: tRNA modification namespace: biological_process alt_id: GO:0016549 def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "tRNA editing" NARROW [GOC:hjd] xref: MIPS_funcat:11.06.02 is_a: GO:0008033 ! tRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] xref: MIPS_funcat:01.03.16 xref: MIPS_funcat:01.03.16.01 is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006402 name: mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] synonym: "mRNA breakdown" EXACT [] synonym: "mRNA catabolism" EXACT [] synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] synonym: "mRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! import into nucleus [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006406 name: mRNA export from nucleus namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "mRNA export from cell nucleus" EXACT [] synonym: "mRNA export out of nucleus" EXACT [] synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "mRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051028 ! mRNA transport relationship: part_of GO:0010467 ! gene expression relationship: part_of GO:0071427 ! mRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006407 name: rRNA export from nucleus namespace: biological_process def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah] synonym: "rRNA export from cell nucleus" EXACT [] synonym: "rRNA export out of nucleus" EXACT [] synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] synonym: "rRNA-nucleus export" EXACT [] is_a: GO:0051029 ! rRNA transport is_a: GO:0097064 ! ncRNA export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis relationship: part_of GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006408 name: snRNA export from nucleus namespace: biological_process def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "snRNA export from cell nucleus" EXACT [] synonym: "snRNA export out of nucleus" EXACT [] synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] synonym: "snRNA-nucleus export" EXACT [] is_a: GO:0051030 ! snRNA transport is_a: GO:0097064 ! ncRNA export from nucleus [Term] id: GO:0006409 name: tRNA export from nucleus namespace: biological_process def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "tRNA export from cell nucleus" EXACT [] synonym: "tRNA export out of nucleus" EXACT [] synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] synonym: "tRNA-nucleus export" EXACT [] is_a: GO:0051031 ! tRNA transport is_a: GO:0097064 ! ncRNA export from nucleus relationship: part_of GO:0071431 ! tRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006410 name: obsolete transcription, RNA-dependent namespace: biological_process def: "OBSOLETE. The cellular synthesis of DNA on a template of RNA." [GOC:jl] comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis. synonym: "transcription, RNA-dependent" EXACT [] is_obsolete: true [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: MIPS_funcat:12 xref: Wikipedia:Translation_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044267 ! cellular protein metabolic process relationship: has_part GO:0006414 ! translational elongation relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] xref: MIPS_funcat:12.04.01 is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: MIPS_funcat:12.04.02 is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: MIPS_funcat:12.04.03 is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006412 ! translation relationship: regulates GO:0006412 ! translation [Term] id: GO:0006418 name: tRNA aminoacylation for protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] subset: goslim_yeast synonym: "tRNA charging" NARROW [] xref: MetaCyc:TRNA-CHARGING-PWY is_a: GO:0043039 ! tRNA aminoacylation relationship: part_of GO:0006412 ! translation [Term] id: GO:0006419 name: alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006420 name: arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006421 name: asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006422 name: aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA." [GOC:mah, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006423 name: cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006424 name: glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006425 name: glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006426 name: glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006427 name: histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006428 name: isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006429 name: leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006430 name: lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006431 name: methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006432 name: phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006433 name: prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA." [GOC:mah, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006434 name: seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation relationship: has_part GO:0097056 ! selenocysteinyl-tRNA(Sec) biosynthetic process [Term] id: GO:0006435 name: threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006436 name: tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006437 name: tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase.The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.T" [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006438 name: valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006439 name: obsolete aminoacyl-tRNA hydrolase reaction namespace: biological_process def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] comment: This term was made obsolete because it represents a molecular function. synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004045 [Term] id: GO:0006441 name: obsolete binding to mRNA cap namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because it represents a function rather than a process. synonym: "binding to mRNA cap" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006413 ! translational initiation relationship: regulates GO:0006413 ! translational initiation [Term] id: GO:0006447 name: regulation of translational initiation by iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] is_a: GO:0006446 ! regulation of translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006414 ! translational elongation relationship: regulates GO:0006414 ! translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006415 ! translational termination relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006450 name: regulation of translational fidelity namespace: biological_process alt_id: GO:0000029 def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] synonym: "regulation of translational accuracy" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0006451 name: translational readthrough namespace: biological_process def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232] synonym: "natural nonsense suppression" RELATED [] is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006452 name: translational frameshifting namespace: biological_process def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] xref: Wikipedia:Translational_frameshift is_a: GO:0006414 ! translational elongation [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: MIPS_funcat:14 xref: MIPS_funcat:14.01 xref: Wikipedia:Protein_folding is_a: GO:0009987 ! cellular process [Term] id: GO:0006458 name: 'de novo' protein folding namespace: biological_process def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] synonym: "nascent chain protein folding" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0006459 name: obsolete binding unfolded ER proteins namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "binding unfolded ER proteins" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0051082 [Term] id: GO:0006460 name: obsolete peptidyl-prolyl isomerase B reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "peptidyl-prolyl isomerase B reaction" EXACT [] is_obsolete: true consider: GO:0003755 [Term] id: GO:0006462 name: obsolete protein complex assembly, multichaperone pathway namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. synonym: "protein complex assembly, multichaperone pathway" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051131 [Term] id: GO:0006463 name: steroid hormone receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] xref: MIPS_funcat:14 xref: MIPS_funcat:14.07 xref: MIPS_funcat:18.01.01 is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006465 name: signal peptide processing namespace: biological_process def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] synonym: "leader peptide processing" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006466 name: obsolete protein disulfide-isomerase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it presents a molecular function. synonym: "protein disulfide-isomerase reaction" EXACT [] synonym: "protein disulphide-isomerase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003756 [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.03 is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004672 ! protein kinase activity relationship: negatively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0006470 name: protein dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.03 is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0006471 name: protein ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf] xref: RESID:AA0040 xref: RESID:AA0168 xref: RESID:AA0169 xref: RESID:AA0231 xref: RESID:AA0237 xref: RESID:AA0295 is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0006473 name: protein acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] synonym: "protein amino acid acetylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.04 is_a: GO:0043543 ! protein acylation [Term] id: GO:0006474 name: N-terminal protein amino acid acetylation namespace: biological_process def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267] is_a: GO:0006473 ! protein acetylation is_a: GO:0031365 ! N-terminal protein amino acid modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] is_a: GO:0006473 ! protein acetylation [Term] id: GO:0006476 name: protein deacetylation namespace: biological_process def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] synonym: "protein amino acid deacetylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.04 is_a: GO:0035601 ! protein deacylation [Term] id: GO:0006477 name: protein sulfation namespace: biological_process def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators] synonym: "protein amino acid sulfation" EXACT [GOC:bf] synonym: "protein amino acid sulphation" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0051923 ! sulfation [Term] id: GO:0006478 name: peptidyl-tyrosine sulfation namespace: biological_process def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] synonym: "peptidyl-tyrosine sulphation" EXACT [] xref: RESID:AA0172 is_a: GO:0006477 ! protein sulfation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0006479 name: protein methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] synonym: "protein amino acid methylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.09 is_a: GO:0008213 ! protein alkylation is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006480 name: N-terminal protein amino acid methylation namespace: biological_process def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] is_a: GO:0006479 ! protein methylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006481 name: C-terminal protein methylation namespace: biological_process def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0006479 ! protein methylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006482 name: protein demethylation namespace: biological_process def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] synonym: "protein amino acid demethylation" EXACT [GOC:bf] is_a: GO:0008214 ! protein dealkylation is_a: GO:0070988 ! demethylation [Term] id: GO:0006483 name: obsolete peptidyl-aspartic acid/asparagine hydroxylation namespace: biological_process def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "aspartic acid/asparagine hydroxylation" EXACT [] synonym: "peptidyl-aspartic acid/asparagine hydroxylation" EXACT [] is_obsolete: true consider: GO:0042264 consider: GO:0042265 [Term] id: GO:0006484 name: obsolete protein cysteine-thiol oxidation namespace: biological_process def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] comment: This term was made obsolete because it represents a single activity. synonym: "protein cysteine-thiol oxidation" EXACT [] is_obsolete: true consider: GO:0003756 [Term] id: GO:0006486 name: protein glycosylation namespace: biological_process alt_id: GO:0065006 def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] subset: goslim_pombe subset: goslim_yeast synonym: "protein amino acid glycosylation" EXACT [GOC:bf] synonym: "protein-carbohydrate complex assembly" RELATED [] xref: MIPS_funcat:14.07.02 is_a: GO:0006464 ! cellular protein modification process is_a: GO:0043413 ! macromolecule glycosylation relationship: part_of GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006487 name: protein N-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.02.02 xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006488 name: dolichol-linked oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309] synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] synonym: "dolichol-linked oligosaccharide formation" EXACT [] synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161] synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161] synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] is_a: GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process relationship: part_of GO:0006487 ! protein N-linked glycosylation [Term] id: GO:0006489 name: dolichyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732] synonym: "dolichyl diphosphate anabolism" EXACT [] synonym: "dolichyl diphosphate biosynthesis" EXACT [] synonym: "dolichyl diphosphate formation" EXACT [] synonym: "dolichyl diphosphate synthesis" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046465 ! dolichyl diphosphate metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006490 name: oligosaccharide-lipid intermediate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb] synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr] synonym: "oligosaccharide-lipid intermediate biosynthetic process" NARROW [GOC:pr] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0006491 name: N-glycan processing namespace: biological_process alt_id: GO:0006492 def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] synonym: "glycoprotein trimming involved in glycoprotein maturation" NARROW [] synonym: "N-linked glycoprotein maturation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006493 name: protein O-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.02.01 xref: RESID:AA0153 xref: RESID:AA0154 xref: RESID:AA0155 xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006494 name: obsolete protein amino acid terminal glycosylation namespace: biological_process def: "OBSOLETE. A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. synonym: "protein amino acid terminal glycosylation" EXACT [] is_obsolete: true consider: GO:0006486 [Term] id: GO:0006495 name: obsolete terminal O-glycosylation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "terminal O-glycosylation" EXACT [] is_obsolete: true [Term] id: GO:0006496 name: obsolete protein amino acid terminal N-glycosylation namespace: biological_process def: "OBSOLETE. The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. synonym: "protein amino acid terminal N-glycosylation" EXACT [] is_obsolete: true consider: GO:0006487 consider: GO:0035629 [Term] id: GO:0006497 name: protein lipidation namespace: biological_process alt_id: GO:0042050 def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. subset: goslim_drosophila subset: goslim_yeast synonym: "lipid:protein modification" EXACT [] synonym: "protein amino acid lipidation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.01 xref: RESID:AA0059 xref: RESID:AA0060 xref: RESID:AA0077 xref: RESID:AA0078 xref: RESID:AA0079 xref: RESID:AA0080 xref: RESID:AA0102 xref: RESID:AA0103 xref: RESID:AA0104 xref: RESID:AA0106 xref: RESID:AA0107 xref: RESID:AA0158 xref: RESID:AA0159 xref: RESID:AA0160 xref: RESID:AA0161 xref: RESID:AA0162 xref: RESID:AA0163 xref: RESID:AA0166 xref: RESID:AA0223 xref: RESID:AA0290 xref: RESID:AA0307 xref: RESID:AA0308 xref: RESID:AA0309 xref: RESID:AA0316 is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0042158 ! lipoprotein biosynthetic process [Term] id: GO:0006498 name: N-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl] is_a: GO:0006497 ! protein lipidation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006499 name: N-terminal protein myristoylation namespace: biological_process def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0006500 name: N-terminal protein palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0006501 name: C-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the carboxy-terminus of a protein." [GOC:jl] is_a: GO:0006497 ! protein lipidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006502 name: obsolete C-terminal protein prenylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy-terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein prenylation" EXACT [] is_obsolete: true replaced_by: GO:0018342 [Term] id: GO:0006503 name: obsolete C-terminal protein farnesylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein farnesylation" EXACT [] is_obsolete: true replaced_by: GO:0018343 [Term] id: GO:0006504 name: obsolete C-terminal protein geranylgeranylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy-terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein geranylgeranylation" EXACT [] is_obsolete: true replaced_by: GO:0018344 [Term] id: GO:0006505 name: GPI anchor metabolic process namespace: biological_process alt_id: GO:0046472 def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732] synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] synonym: "glycosylphosphatidylinositol metabolism" EXACT [] synonym: "GPI anchor metabolism" EXACT [] synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006506 name: GPI anchor biosynthetic process namespace: biological_process alt_id: GO:0015998 def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] synonym: "GPI anchor anabolism" EXACT [] synonym: "GPI anchor biosynthesis" EXACT [] synonym: "GPI anchor formation" EXACT [] synonym: "GPI anchor synthesis" EXACT [] synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] is_a: GO:0006497 ! protein lipidation is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0006661 ! phosphatidylinositol biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process [Term] id: GO:0006507 name: GPI anchor release namespace: biological_process def: "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934] is_a: GO:0006505 ! GPI anchor metabolic process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006509 name: membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] synonym: "ectoderm shedding" BROAD [GOC:pm, PMID:12096138, PMID:15672459, PMID:18419754] synonym: "ectodomain cleavage" EXACT [PMID:18757500] synonym: "membrane protein solubilization" RELATED [] synonym: "receptor shedding" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0006510 name: obsolete ATP-dependent proteolysis namespace: biological_process def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] comment: This term was made obsolete because it represents a molecular function. synonym: "ATP-dependent peptidolysis" EXACT [] synonym: "ATP-dependent proteolysis" EXACT [] is_obsolete: true replaced_by: GO:0004176 consider: GO:0006508 consider: GO:0016485 consider: GO:0051603 [Term] id: GO:0006511 name: ubiquitin-dependent protein catabolic process namespace: biological_process alt_id: GO:0042787 alt_id: GO:0043432 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] synonym: "protein degradation tagging activity" BROAD [] synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] synonym: "protein ubiquitination involved in ubiquitin-dependent protein catabolic process" RELATED [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [] synonym: "ubiquitin-dependent protein breakdown" EXACT [] synonym: "ubiquitin-dependent protein catabolism" EXACT [] synonym: "ubiquitin-dependent protein degradation" EXACT [] synonym: "ubiquitin-dependent proteolysis" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0006512 name: obsolete ubiquitin cycle namespace: biological_process def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. synonym: "ubiquitin cycle" EXACT [] is_obsolete: true [Term] id: GO:0006513 name: protein monoubiquitination namespace: biological_process def: "Addition of a single ubiquitin group to a protein." [GOC:ai] synonym: "protein monoubiquitinylation" EXACT [] synonym: "protein monoubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0006515 name: protein quality control for misfolded or incompletely synthesized proteins namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolic process" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] synonym: "protein quality control (PQC)" EXACT [] synonym: "protein quality control by the ubiquitin-proteasome system" BROAD [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0006517 name: protein deglycosylation namespace: biological_process def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] synonym: "glycoprotein deglycosylation" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "amino acid and derivative metabolism" EXACT [] synonym: "amino acid metabolic process" EXACT [] synonym: "cellular amino acid and derivative metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01 is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006521 name: regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01.13 is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006520 ! cellular amino acid metabolic process relationship: regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006522 name: alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine metabolism" EXACT [] xref: MIPS_funcat:01.01.11.01 is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0006523 name: alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine anabolism" EXACT [] synonym: "alanine biosynthesis" EXACT [] synonym: "alanine formation" EXACT [] synonym: "alanine synthesis" EXACT [] xref: MIPS_funcat:01.01.11.01.01 is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process [Term] id: GO:0006524 name: alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine breakdown" EXACT [] synonym: "alanine catabolism" EXACT [] synonym: "alanine degradation" EXACT [] xref: MIPS_funcat:01.01.11.01.02 is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009080 ! pyruvate family amino acid catabolic process [Term] id: GO:0006525 name: arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] synonym: "arginine metabolism" EXACT [] xref: MIPS_funcat:01.01.03.05 xref: Wikipedia:Arginine is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006526 name: arginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732] synonym: "arginine anabolism" EXACT [] synonym: "arginine biosynthesis" EXACT [] synonym: "arginine formation" EXACT [] synonym: "arginine synthesis" EXACT [] xref: MetaCyc:ARGININE-SYN4-PWY xref: MetaCyc:ARGSYN-PWY xref: MetaCyc:ARGSYNBSUB-PWY xref: MIPS_funcat:01.01.03.05.01 is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006527 name: arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] synonym: "arginine breakdown" EXACT [] synonym: "arginine catabolism" EXACT [] synonym: "arginine degradation" EXACT [] xref: MIPS_funcat:01.01.03.05.02 is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006528 name: asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine metabolism" EXACT [] xref: MetaCyc:ASPARAGINESYN-PWY xref: MIPS_funcat:01.01.06.02 is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006529 name: asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine anabolism" EXACT [] synonym: "asparagine biosynthesis" EXACT [] synonym: "asparagine formation" EXACT [] synonym: "asparagine synthesis" EXACT [] xref: MIPS_funcat:01.01.06.02.01 is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0006530 name: asparagine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine breakdown" EXACT [] synonym: "asparagine catabolism" EXACT [] synonym: "asparagine degradation" EXACT [] xref: MIPS_funcat:01.01.06.02.02 is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0006531 name: aspartate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate metabolism" EXACT [] xref: MIPS_funcat:01.01.06.01 is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006532 name: aspartate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate anabolism" EXACT [] synonym: "aspartate biosynthesis" EXACT [] synonym: "aspartate formation" EXACT [] synonym: "aspartate synthesis" EXACT [] xref: MIPS_funcat:01.01.06.01.01 is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0006533 name: aspartate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate breakdown" EXACT [] synonym: "aspartate catabolism" EXACT [] synonym: "aspartate degradation" EXACT [] xref: MIPS_funcat:01.01.06.01.02 is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0006534 name: cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine metabolism" EXACT [] xref: MIPS_funcat:01.01.09.03 xref: Wikipedia:Cysteine_metabolism is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006535 name: cysteine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] synonym: "cysteine anabolism from serine" EXACT [] synonym: "cysteine formation from serine" EXACT [] synonym: "cysteine synthesis from serine" EXACT [] xref: MetaCyc:CYSTSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: MIPS_funcat:01.01.03.02 xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] xref: MIPS_funcat:01.01.03.02.01 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0006538 name: glutamate catabolic process namespace: biological_process alt_id: GO:0019459 def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate deamidation" RELATED [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] xref: MIPS_funcat:01.01.03.02.02 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0006539 name: glutamate catabolic process via 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] xref: MetaCyc:P162-PWY is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006540 name: glutamate decarboxylation to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively). synonym: "4-aminobutyrate shunt" EXACT [] synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY] synonym: "GABA shunt" EXACT [] synonym: "gamma-aminobutyrate shunt" EXACT [] synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY] synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY] xref: MetaCyc:GLUDEG-I-PWY xref: MetaCyc:PWY-4321 xref: MetaCyc:PWY3O-210 is_a: GO:0006538 ! glutamate catabolic process relationship: has_part GO:0003867 ! 4-aminobutyrate transaminase activity relationship: has_part GO:0004351 ! glutamate decarboxylase activity [Term] id: GO:0006541 name: glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine metabolism" EXACT [] xref: MIPS_funcat:01.01.03.01 is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006542 name: glutamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine anabolism" EXACT [] synonym: "glutamine biosynthesis" EXACT [] synonym: "glutamine formation" EXACT [] synonym: "glutamine synthesis" EXACT [] xref: MetaCyc:GLNSYN-PWY xref: MIPS_funcat:01.01.03.01.01 is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006543 name: glutamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine breakdown" EXACT [] synonym: "glutamine catabolism" EXACT [] synonym: "glutamine degradation" EXACT [] xref: MIPS_funcat:01.01.03.01.02 is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine metabolism" EXACT [] xref: MIPS_funcat:01.01.09.01 is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY xref: MIPS_funcat:01.01.09.01.01 is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] xref: MIPS_funcat:01.01.09.01.02 is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006547 name: histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine metabolism" EXACT [] xref: MIPS_funcat:01.01.09.07 xref: Wikipedia:Histidine is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006548 name: histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine breakdown" EXACT [] synonym: "histidine catabolism" EXACT [] synonym: "histidine degradation" EXACT [] xref: MIPS_funcat:01.01.09.07.02 is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006549 name: isoleucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine metabolism" EXACT [] xref: MIPS_funcat:01.01.11.02 is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006550 name: isoleucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine breakdown" EXACT [] synonym: "isoleucine catabolism" EXACT [] synonym: "isoleucine degradation" EXACT [] xref: MetaCyc:ILEUDEG-PWY xref: MIPS_funcat:01.01.11.02.02 is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006551 name: leucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine metabolism" EXACT [] xref: MIPS_funcat:01.01.11.04 is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006552 name: leucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine breakdown" EXACT [] synonym: "leucine catabolism" EXACT [] synonym: "leucine degradation" EXACT [] xref: MetaCyc:LEU-DEG2-PWY xref: MIPS_funcat:01.01.11.04.02 is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine metabolism" EXACT [] xref: MIPS_funcat:01.01.06.06 xref: Wikipedia:Lysine is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006554 name: lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine breakdown" EXACT [] synonym: "lysine catabolism" EXACT [] synonym: "lysine degradation" EXACT [] xref: MIPS_funcat:01.01.06.06.02 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006555 name: methionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "methionine metabolism" EXACT [] xref: MIPS_funcat:01.01.06.05 xref: UM-BBD_pathwayID:met is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006556 name: S-adenosylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] synonym: "S-adenosyl methionine biosynthesis" EXACT [] synonym: "S-adenosyl methionine biosynthetic process" EXACT [] synonym: "S-adenosylmethionine anabolism" EXACT [] synonym: "S-adenosylmethionine biosynthesis" EXACT [] synonym: "S-adenosylmethionine formation" EXACT [] synonym: "S-adenosylmethionine synthesis" EXACT [] synonym: "SAM biosynthetic process" EXACT [] xref: MetaCyc:SAM-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0006557 name: S-adenosylmethioninamine biosynthetic process namespace: biological_process alt_id: GO:0006745 def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] synonym: "S-adenosylmethioninamine anabolism" EXACT [] synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] synonym: "S-adenosylmethioninamine formation" EXACT [] synonym: "S-adenosylmethioninamine synthesis" EXACT [] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process [Term] id: GO:0006558 name: L-phenylalanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah] synonym: "L-phenylalanine metabolism" EXACT [] synonym: "phenylalanine metabolic process" BROAD [] synonym: "phenylalanine metabolism" BROAD [] xref: MIPS_funcat:01.01.09.04 is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [Term] id: GO:0006559 name: L-phenylalanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] synonym: "L-phenylalanine breakdown" EXACT [] synonym: "L-phenylalanine catabolism" EXACT [] synonym: "L-phenylalanine degradation" EXACT [] synonym: "phenylalanine catabolic process" BROAD [] synonym: "phenylalanine catabolism" BROAD [] xref: MIPS_funcat:01.01.09.04.02 is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [Term] id: GO:0006560 name: proline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "proline metabolism" EXACT [] xref: MIPS_funcat:01.01.03.03 is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006561 name: proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] synonym: "proline anabolism" EXACT [] synonym: "proline biosynthesis" EXACT [] synonym: "proline formation" EXACT [] synonym: "proline synthesis" EXACT [] xref: MetaCyc:PROSYN-PWY xref: MetaCyc:PWY-3341 xref: MIPS_funcat:01.01.03.03.01 is_a: GO:0006560 ! proline metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006562 name: proline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "proline breakdown" EXACT [] synonym: "proline catabolism" EXACT [] synonym: "proline degradation" EXACT [] xref: MIPS_funcat:01.01.03.03.02 is_a: GO:0006560 ! proline metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0006563 name: L-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] synonym: "L-serine metabolism" EXACT [] xref: MIPS_funcat:01.01.09.02 xref: MIPS_funcat:01.01.11.07 is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006564 name: L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] synonym: "L-serine anabolism" EXACT [] synonym: "L-serine biosynthesis" EXACT [] synonym: "L-serine formation" EXACT [] synonym: "L-serine synthesis" EXACT [] xref: MetaCyc:SERSYN-PWY xref: MIPS_funcat:01.01.09.02.01 is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006565 name: L-serine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] synonym: "L-serine breakdown" EXACT [] synonym: "L-serine catabolism" EXACT [] synonym: "L-serine degradation" EXACT [] xref: MetaCyc:SERDEG-PWY xref: MIPS_funcat:01.01.09.02.02 is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006566 name: threonine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "threonine metabolism" EXACT [] xref: MIPS_funcat:01.01.06.04 xref: MIPS_funcat:01.01.11.07 xref: UM-BBD_pathwayID:met is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006567 name: threonine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "threonine breakdown" EXACT [] synonym: "threonine catabolism" EXACT [] synonym: "threonine degradation" EXACT [] xref: MetaCyc:THREOCAT-PWY xref: MIPS_funcat:01.01.06.04.02 xref: UM-BBD_pathwayID:met is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006568 name: tryptophan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] synonym: "tryptophan metabolism" EXACT [] xref: MIPS_funcat:01.01.09.06 xref: Wikipedia:Tryptophan is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006569 name: tryptophan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] synonym: "tryptophan breakdown" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] synonym: "tryptophan catabolism" EXACT [] synonym: "tryptophan catabolism, using tryptophanase" NARROW [] synonym: "tryptophan degradation" EXACT [] xref: MIPS_funcat:01.01.09.06.02 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0046218 ! indolalkylamine catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006570 name: tyrosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] synonym: "tyrosine metabolism" EXACT [] xref: MIPS_funcat:01.01.09.05 xref: UM-BBD_pathwayID:tyr xref: Wikipedia:Tyrosine is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006571 name: tyrosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] synonym: "tyrosine anabolism" EXACT [] synonym: "tyrosine biosynthesis" EXACT [] synonym: "tyrosine formation" EXACT [] synonym: "tyrosine synthesis" EXACT [] xref: MetaCyc:PWY-3461 xref: MIPS_funcat:01.01.09.05.01 is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0006572 name: tyrosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] synonym: "tyrosine breakdown" EXACT [] synonym: "tyrosine catabolism" EXACT [] synonym: "tyrosine degradation" EXACT [] xref: MIPS_funcat:01.01.09.05.02 is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006573 name: valine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine metabolism" EXACT [] xref: MIPS_funcat:01.01.11.03 is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006574 name: valine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine breakdown" EXACT [] synonym: "valine catabolism" EXACT [] synonym: "valine degradation" EXACT [] xref: MetaCyc:VALDEG-PWY xref: MIPS_funcat:01.01.11.03.02 is_a: GO:0006573 ! valine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006576 name: cellular biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine metabolism" EXACT [] is_a: GO:0044106 ! cellular amine metabolic process [Term] id: GO:0006577 name: amino-acid betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine metabolic process" EXACT [] synonym: "betaine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0006578 name: amino-acid betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine anabolism" EXACT [] synonym: "betaine biosynthesis" EXACT [] synonym: "betaine biosynthetic process" EXACT [] synonym: "betaine formation" EXACT [] synonym: "betaine synthesis" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0006579 name: amino-acid betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine breakdown" EXACT [] synonym: "betaine catabolic process" EXACT [] synonym: "betaine catabolism" EXACT [] synonym: "betaine degradation" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0006580 name: ethanolamine metabolic process namespace: biological_process alt_id: GO:0006645 def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [ISBN:0192800981] synonym: "ethanolamine metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0006582 name: melanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] synonym: "melanin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0006583 name: melanin biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] synonym: "melanin anabolism from tyrosine" EXACT [] synonym: "melanin formation from tyrosine" EXACT [] synonym: "melanin synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042438 ! melanin biosynthetic process [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006585 name: dopamine biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "dopamine anabolism from tyrosine" EXACT [] synonym: "dopamine formation from tyrosine" EXACT [] synonym: "dopamine synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042416 ! dopamine biosynthetic process [Term] id: GO:0006586 name: indolalkylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] synonym: "indolalkylamine metabolism" EXACT [] synonym: "indolamine metabolic process" BROAD [] synonym: "indolamine metabolism" BROAD [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0006587 name: serotonin biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism from tryptophan" EXACT [] synonym: "serotonin formation from tryptophan" EXACT [] synonym: "serotonin synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0042427 ! serotonin biosynthetic process [Term] id: GO:0006588 name: activation of tryptophan 5-monooxygenase activity namespace: biological_process def: "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan [Term] id: GO:0006589 name: octopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] synonym: "octopamine anabolism" EXACT [] synonym: "octopamine biosynthesis" EXACT [] synonym: "octopamine formation" EXACT [] synonym: "octopamine synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process [Term] id: GO:0006591 name: ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006592 name: ornithine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine anabolism" EXACT [] synonym: "ornithine biosynthesis" EXACT [] synonym: "ornithine formation" EXACT [] synonym: "ornithine synthesis" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0006593 name: ornithine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine breakdown" EXACT [] synonym: "ornithine catabolism" EXACT [] synonym: "ornithine degradation" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006595 name: polyamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine metabolism" EXACT [] xref: MIPS_funcat:01.01.05 xref: MIPS_funcat:01.01.05.01 is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0006596 name: polyamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine anabolism" EXACT [] synonym: "polyamine biosynthesis" EXACT [] synonym: "polyamine formation" EXACT [] synonym: "polyamine synthesis" EXACT [] xref: MetaCyc:POLYAMSYN-PWY xref: MIPS_funcat:01.01.05.01.01 is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0006597 name: spermine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [GOC:curators] synonym: "spermine anabolism" EXACT [] synonym: "spermine biosynthesis" EXACT [] synonym: "spermine formation" EXACT [] synonym: "spermine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0006598 name: polyamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine breakdown" EXACT [] synonym: "polyamine catabolism" EXACT [] synonym: "polyamine degradation" EXACT [] xref: MIPS_funcat:01.01.05.01.02 is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006599 name: phosphagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] synonym: "phosphagen metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0006600 name: creatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] synonym: "creatine metabolism" EXACT [] xref: MIPS_funcat:01.01.05 xref: MIPS_funcat:01.01.05.02 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006601 name: creatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] synonym: "creatine anabolism" EXACT [] synonym: "creatine biosynthesis" EXACT [] synonym: "creatine formation" EXACT [] synonym: "creatine synthesis" EXACT [] xref: MIPS_funcat:01.01.05.02.01 is_a: GO:0006600 ! creatine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0006602 name: creatinine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732] synonym: "creatinine breakdown" EXACT [] synonym: "creatinine catabolism" EXACT [] synonym: "creatinine degradation" EXACT [] xref: MIPS_funcat:01.01.05.02.02 is_a: GO:0046449 ! creatinine metabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0006603 name: phosphocreatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [PMID:16371597] synonym: "phosphocreatine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006604 name: phosphoarginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597] synonym: "phosphoarginine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: MIPS_funcat:14 xref: MIPS_funcat:14.04 xref: Wikipedia:Protein_targeting is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0017038 ! protein import is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0051170 ! import into nucleus is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0006607 name: NLS-bearing protein import into nucleus namespace: biological_process def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai] synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] synonym: "NLS-bearing substrate import into nucleus" EXACT [GOC:bf, GOC:jl] synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] synonym: "NLS-bearing substrate-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006608 name: obsolete snRNP protein import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "snRNP protein import into cell nucleus" EXACT [] synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] synonym: "snRNP protein-nucleus import" EXACT [] is_obsolete: true consider: GO:0006606 [Term] id: GO:0006609 name: obsolete mRNA-binding (hnRNP) protein import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] is_obsolete: true consider: GO:0006606 [Term] id: GO:0006610 name: ribosomal protein import into nucleus namespace: biological_process def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus." [GOC:ai, PMID:11809816] comment: Ribosomal protein rpl12 uses a different import pathway, which is why it has a separate GO term. See discussion in https://github.com/geneontology/go-annotation/issues/1700. synonym: "ribosomal protein import into cell nucleus" EXACT [] synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] synonym: "ribosomal protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process alt_id: GO:0097349 def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006612 name: protein targeting to membrane namespace: biological_process def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators] synonym: "protein membrane targeting" EXACT [] synonym: "protein-membrane targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0090150 ! establishment of protein localization to membrane [Term] id: GO:0006613 name: cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] synonym: "cotranslational membrane targeting" EXACT [] synonym: "cotranslational protein membrane targeting" EXACT [] synonym: "cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane [Term] id: GO:0006614 name: SRP-dependent cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006613 ! cotranslational protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER relationship: has_part GO:0006412 ! translation [Term] id: GO:0006615 name: SRP-dependent cotranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] is_a: GO:0022615 ! protein to membrane docking relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006616 name: SRP-dependent cotranslational protein targeting to membrane, translocation namespace: biological_process def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006617 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition namespace: biological_process def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006618 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing namespace: biological_process def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] is_a: GO:0006465 ! signal peptide processing relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006619 name: obsolete SRP-independent cotranslational protein-membrane targeting namespace: biological_process def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "ER translocation" BROAD [] synonym: "SRP-independent cotranslational membrane targeting" EXACT [] synonym: "SRP-independent cotranslational protein-membrane targeting" EXACT [] is_obsolete: true [Term] id: GO:0006620 name: posttranslational protein targeting to endoplasmic reticulum membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] synonym: "posttranslational endoplasmic reticulum membrane targeting" EXACT [] synonym: "posttranslational endoplasmic reticulum protein-membrane targeting" EXACT [] synonym: "posttranslational protein endoplasmic reticulum membrane targeting" EXACT [] synonym: "posttranslational protein targeting to ER membrane" EXACT [] synonym: "SRP-independent endoplasmic reticulum protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006621 name: protein retention in ER lumen namespace: biological_process def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum [Term] id: GO:0006622 name: protein targeting to lysosome namespace: biological_process def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators] synonym: "protein-lysosome targeting" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0007041 ! lysosomal transport is_a: GO:0061462 ! protein localization to lysosome [Term] id: GO:0006623 name: protein targeting to vacuole namespace: biological_process def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators] synonym: "protein vacuolar targeting" EXACT [] synonym: "protein-vacuolar targeting" EXACT [] synonym: "protein-vacuole targeting" EXACT [] synonym: "vacuolar protein sorting" EXACT [GOC:vw] is_a: GO:0006605 ! protein targeting is_a: GO:0007034 ! vacuolar transport is_a: GO:0072666 ! establishment of protein localization to vacuole [Term] id: GO:0006624 name: vacuolar protein processing namespace: biological_process def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah] synonym: "vacuolar protein maturation" RELATED [] synonym: "vacuolar proteolysis" RELATED [] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process intersection_of: GO:0016485 ! protein processing intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole [Term] id: GO:0006625 name: protein targeting to peroxisome namespace: biological_process def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] synonym: "protein-peroxisome targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0043574 ! peroxisomal transport is_a: GO:0072663 ! establishment of protein localization to peroxisome [Term] id: GO:0006626 name: protein targeting to mitochondrion namespace: biological_process alt_id: GO:0043681 def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] synonym: "mitochondrial protein import" RELATED [] synonym: "mitochondrial translocation" RELATED [] synonym: "protein import into mitochondrion" EXACT [] synonym: "protein targeting to mitochondria" EXACT [] synonym: "protein-mitochondrial targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0006839 ! mitochondrial transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0006627 name: protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] synonym: "mitochondrial processing" BROAD [] synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb] is_a: GO:0034982 ! mitochondrial protein processing intersection_of: GO:0016485 ! protein processing intersection_of: part_of GO:0006626 ! protein targeting to mitochondrion relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0006628 name: obsolete mitochondrial translocation namespace: biological_process def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. synonym: "mitochondrial translocation" EXACT [] is_obsolete: true consider: GO:0006626 [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: MIPS_funcat:01.06 xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006630 name: obsolete lipid binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "lipid binding" EXACT [] is_obsolete: true consider: GO:0008289 [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] synonym: "fatty acid metabolism" EXACT [] xref: MIPS_funcat:01.06 xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006633 name: fatty acid biosynthetic process namespace: biological_process alt_id: GO:0000037 def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] synonym: "fatty acid anabolism" EXACT [] synonym: "fatty acid biosynthesis" EXACT [] synonym: "fatty acid formation" EXACT [] synonym: "fatty acid synthesis" EXACT [] xref: MetaCyc:FASYN-INITIAL-PWY xref: MetaCyc:PWY-4381 xref: MetaCyc:PWY-5156 xref: MIPS_funcat:01.06.01 xref: MIPS_funcat:01.06.01.05 xref: Wikipedia:Fatty_acid_synthesis is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0006634 name: hexadecanal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] synonym: "hexadecanal anabolism" EXACT [] synonym: "hexadecanal biosynthesis" EXACT [] synonym: "hexadecanal formation" EXACT [] synonym: "hexadecanal synthesis" EXACT [] synonym: "palmitaldehyde biosynthesis" EXACT [] synonym: "palmitaldehyde biosynthetic process" EXACT [] is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046458 ! hexadecanal metabolic process [Term] id: GO:0006635 name: fatty acid beta-oxidation namespace: biological_process def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0006636 name: unsaturated fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] synonym: "fatty acid desaturation" RELATED [] synonym: "polyunsaturated fatty acid biosynthesis" NARROW [GOC:yaf, MetaCyc:PWY-762] synonym: "unsaturated fatty acid anabolism" EXACT [] synonym: "unsaturated fatty acid biosynthesis" EXACT [] synonym: "unsaturated fatty acid formation" EXACT [] synonym: "unsaturated fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006637 name: acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] synonym: "acyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process is_a: GO:0035383 ! thioester metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006638 name: neutral lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] synonym: "neutral lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006639 name: acylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732] synonym: "acylglycerol metabolism" EXACT [] synonym: "glyceride metabolic process" EXACT [] synonym: "glyceride metabolism" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006640 name: monoacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732] synonym: "monoacylglycerol anabolism" EXACT [] synonym: "monoacylglycerol biosynthesis" EXACT [] synonym: "monoacylglycerol formation" EXACT [] synonym: "monoacylglycerol synthesis" EXACT [] synonym: "monoglyceride biosynthesis" EXACT [] synonym: "monoglyceride biosynthetic process" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006641 name: triglyceride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732] synonym: "triacylglycerol metabolic process" EXACT [] synonym: "triacylglycerol metabolism" EXACT [] synonym: "triglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0006642 name: triglyceride mobilization namespace: biological_process def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] synonym: "triacylglycerol mobilization" EXACT [] is_a: GO:0006641 ! triglyceride metabolic process [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006644 name: phospholipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006646 name: phosphatidylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] synonym: "phosphatidylethanolamine anabolism" EXACT [] synonym: "phosphatidylethanolamine biosynthesis" EXACT [] synonym: "phosphatidylethanolamine formation" EXACT [] synonym: "phosphatidylethanolamine synthesis" EXACT [] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006647 name: phosphatidyl-N-monomethylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] synonym: "PMME biosynthesis" EXACT [] synonym: "PMME biosynthetic process" EXACT [] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process [Term] id: GO:0006648 name: dihydrosphingosine-1-P pathway namespace: biological_process def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process [Term] id: GO:0006649 name: phospholipid transfer to membrane namespace: biological_process def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] is_a: GO:0015914 ! phospholipid transport relationship: part_of GO:0061024 ! membrane organization [Term] id: GO:0006650 name: glycerophospholipid metabolic process namespace: biological_process alt_id: GO:0006652 def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] synonym: "alpha-glycerophosphate pathway" RELATED [] synonym: "glycerophospholipid metabolism" EXACT [] synonym: "phosphoglyceride metabolic process" EXACT [] synonym: "phosphoglyceride metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006651 name: diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [GOC:curators] synonym: "diacylglycerol anabolism" EXACT [] synonym: "diacylglycerol biosynthesis" EXACT [] synonym: "diacylglycerol formation" EXACT [] synonym: "diacylglycerol synthesis" EXACT [] synonym: "diglyceride biosynthesis" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006653 name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [ISBN:0198506732] synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah] synonym: "lecithin metabolic process" BROAD [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046470 ! phosphatidylcholine metabolic process [Term] id: GO:0006654 name: phosphatidic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732] synonym: "phosphatidic acid anabolism" EXACT [] synonym: "phosphatidic acid biosynthesis" EXACT [] synonym: "phosphatidic acid formation" EXACT [] synonym: "phosphatidic acid synthesis" EXACT [] is_a: GO:0046473 ! phosphatidic acid metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006655 name: phosphatidylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732] synonym: "phosphatidylglycerol anabolism" EXACT [] synonym: "phosphatidylglycerol biosynthesis" EXACT [] synonym: "phosphatidylglycerol formation" EXACT [] synonym: "phosphatidylglycerol synthesis" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006656 name: phosphatidylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732] synonym: "phosphatidylcholine anabolism" EXACT [] synonym: "phosphatidylcholine biosynthesis" EXACT [] synonym: "phosphatidylcholine formation" EXACT [] synonym: "phosphatidylcholine synthesis" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006657 name: CDP-choline pathway namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450] synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450] synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450] xref: MetaCyc:PWY3O-450 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0006658 name: phosphatidylserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732] synonym: "phosphatidylserine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0006659 name: phosphatidylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] synonym: "phosphatidylserine anabolism" EXACT [] synonym: "phosphatidylserine biosynthesis" EXACT [] synonym: "phosphatidylserine formation" EXACT [] synonym: "phosphatidylserine synthesis" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006660 name: phosphatidylserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] synonym: "phosphatidylserine breakdown" EXACT [] synonym: "phosphatidylserine catabolism" EXACT [] synonym: "phosphatidylserine degradation" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0006661 name: phosphatidylinositol biosynthetic process namespace: biological_process alt_id: GO:0046489 def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] synonym: "phosphatidylinositol anabolism" EXACT [] synonym: "phosphatidylinositol biosynthesis" EXACT [] synonym: "phosphatidylinositol formation" EXACT [] synonym: "phosphatidylinositol synthesis" EXACT [] synonym: "phosphoinositide biosynthesis" EXACT [] synonym: "phosphoinositide biosynthetic process" EXACT [] synonym: "PtdIns biosynthesis" EXACT [] synonym: "PtdIns biosynthetic process" EXACT [] is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006662 name: glycerol ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "glycerol ether metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0006663 name: platelet activating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF biosynthesis" EXACT [] synonym: "PAF biosynthetic process" EXACT [] synonym: "platelet activating factor anabolism" EXACT [] synonym: "platelet activating factor biosynthesis" EXACT [] synonym: "platelet activating factor formation" EXACT [] synonym: "platelet activating factor synthesis" EXACT [] is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006664 name: glycolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [ISBN:0198547684] synonym: "glycolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:1903509 ! liposaccharide metabolic process [Term] id: GO:0006665 name: sphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006666 name: 3-keto-sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] synonym: "3-keto-sphinganine metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006667 name: sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18] synonym: "dihydrosphingosine metabolic process" EXACT [] synonym: "dihydrosphingosine metabolism" EXACT [] synonym: "sphinganine metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006668 name: sphinganine-1-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] synonym: "sphinganine-1-phosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006669 name: sphinganine-1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] synonym: "sphinganine-1-phosphate anabolism" EXACT [] synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] synonym: "sphinganine-1-phosphate formation" EXACT [] synonym: "sphinganine-1-phosphate synthesis" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006670 name: sphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732] synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] synonym: "(4E)-sphing-4-enine metabolism" EXACT [] synonym: "sphing-4-enine metabolic process" EXACT [] synonym: "sphing-4-enine metabolism" EXACT [] synonym: "sphingosine metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006671 name: phytosphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [ISBN:0198506732] synonym: "phytosphingosine metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006672 name: ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] synonym: "ceramide metabolism" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006673 name: inositol phosphoceramide metabolic process namespace: biological_process alt_id: GO:0006674 def: "The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] synonym: "inositol phosphorylceramide metabolic process" EXACT [] synonym: "inositol phosphorylceramide metabolism" EXACT [] synonym: "inositolphosphoceramide metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006675 name: mannosyl-inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] synonym: "mannose inositol phosphoceramide metabolic process" EXACT [] synonym: "mannose inositol phosphoceramide metabolism" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] synonym: "MIPC metabolic process" EXACT [] synonym: "MIPC metabolism" EXACT [] is_a: GO:0006673 ! inositol phosphoceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006676 name: mannosyl diphosphorylinositol ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] synonym: "M(IP)2C metabolic process" EXACT [] synonym: "M(IP)2C metabolism" EXACT [] synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0006673 ! inositol phosphoceramide metabolic process [Term] id: GO:0006677 name: glycosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732] synonym: "glycosylceramide metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006678 name: glucosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [ISBN:0198506732] synonym: "glucosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process [Term] id: GO:0006679 name: glucosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] synonym: "glucosylceramide anabolism" EXACT [] synonym: "glucosylceramide biosynthesis" EXACT [] synonym: "glucosylceramide formation" EXACT [] synonym: "glucosylceramide synthesis" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006680 name: glucosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] synonym: "glucosylceramide breakdown" EXACT [] synonym: "glucosylceramide catabolism" EXACT [] synonym: "glucosylceramide degradation" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046477 ! glycosylceramide catabolic process [Term] id: GO:0006681 name: galactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0006682 name: galactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide anabolism" EXACT [] synonym: "galactosylceramide biosynthesis" EXACT [] synonym: "galactosylceramide formation" EXACT [] synonym: "galactosylceramide synthesis" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019375 ! galactolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006683 name: galactosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide breakdown" EXACT [] synonym: "galactosylceramide catabolism" EXACT [] synonym: "galactosylceramide degradation" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019376 ! galactolipid catabolic process is_a: GO:0046477 ! glycosylceramide catabolic process [Term] id: GO:0006684 name: sphingomyelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0006685 name: sphingomyelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin breakdown" EXACT [] synonym: "sphingomyelin catabolism" EXACT [] synonym: "sphingomyelin degradation" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0006686 name: sphingomyelin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin anabolism" EXACT [] synonym: "sphingomyelin biosynthesis" EXACT [] synonym: "sphingomyelin formation" EXACT [] synonym: "sphingomyelin synthesis" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0006687 name: glycosphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] synonym: "glycosphingolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006688 name: glycosphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] synonym: "glycosphingolipid anabolism" EXACT [] synonym: "glycosphingolipid biosynthesis" EXACT [] synonym: "glycosphingolipid formation" EXACT [] synonym: "glycosphingolipid synthesis" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006689 name: ganglioside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] synonym: "ganglioside breakdown" EXACT [] synonym: "ganglioside catabolism" EXACT [] synonym: "ganglioside degradation" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process is_a: GO:0046514 ! ceramide catabolic process [Term] id: GO:0006690 name: icosanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] synonym: "eicosanoid metabolic process" EXACT [] synonym: "eicosanoid metabolism" EXACT [] synonym: "icosanoid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process [Term] id: GO:0006691 name: leukotriene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] synonym: "leukotriene metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0006692 name: prostanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732] synonym: "prostanoid metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006693 name: prostaglandin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732] synonym: "prostaglandin metabolism" EXACT [] is_a: GO:0006692 ! prostanoid metabolic process [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: MIPS_funcat:01.06.01.07.11 xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006695 name: cholesterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol anabolism" EXACT [] synonym: "cholesterol biosynthesis" EXACT [] synonym: "cholesterol formation" EXACT [] synonym: "cholesterol synthesis" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006696 name: ergosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732] synonym: "ergosterol anabolism" EXACT [] synonym: "ergosterol biosynthesis" EXACT [] synonym: "ergosterol formation" EXACT [] synonym: "ergosterol synthesis" EXACT [] is_a: GO:0008204 ! ergosterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:0097384 ! cellular lipid biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006697 name: ecdysone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] synonym: "ecdysone anabolism" EXACT [] synonym: "ecdysone biosynthesis" EXACT [] synonym: "ecdysone formation" EXACT [] synonym: "ecdysone synthesis" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0045456 ! ecdysteroid biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006698 name: obsolete ecdysone modification namespace: biological_process def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. synonym: "ecdysone modification" EXACT [] is_obsolete: true replaced_by: GO:0004501 [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0006700 name: C21-steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone anabolism" EXACT [] synonym: "C21-steroid hormone biosynthesis" EXACT [] synonym: "C21-steroid hormone formation" EXACT [] synonym: "C21-steroid hormone synthesis" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006701 name: progesterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone anabolism" EXACT [] synonym: "progesterone biosynthesis" EXACT [] synonym: "progesterone formation" EXACT [] synonym: "progesterone synthesis" EXACT [] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006702 name: androgen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen anabolism" EXACT [] synonym: "androgen biosynthesis" EXACT [] synonym: "androgen formation" EXACT [] synonym: "androgen synthesis" EXACT [] is_a: GO:0008209 ! androgen metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006703 name: estrogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen anabolism" EXACT [] synonym: "estrogen biosynthesis" EXACT [] synonym: "estrogen formation" EXACT [] synonym: "estrogen synthesis" EXACT [] synonym: "oestrogen biosynthesis" EXACT [] synonym: "oestrogen biosynthetic process" EXACT [] is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006704 name: glucocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006705 name: mineralocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid anabolism" EXACT [] synonym: "mineralocorticoid biosynthesis" EXACT [] synonym: "mineralocorticoid formation" EXACT [] synonym: "mineralocorticoid synthesis" EXACT [] is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0006707 name: cholesterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol breakdown" EXACT [] synonym: "cholesterol catabolism" EXACT [] synonym: "cholesterol degradation" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0006708 name: ecdysone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] synonym: "ecdysone breakdown" EXACT [] synonym: "ecdysone catabolism" EXACT [] synonym: "ecdysone degradation" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046344 ! ecdysteroid catabolic process [Term] id: GO:0006709 name: progesterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone breakdown" EXACT [] synonym: "progesterone catabolism" EXACT [] synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042448 ! progesterone metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006710 name: androgen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen breakdown" EXACT [] synonym: "androgen catabolism" EXACT [] synonym: "androgen degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006711 name: estrogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen breakdown" EXACT [] synonym: "estrogen catabolism" EXACT [] synonym: "estrogen degradation" EXACT [] synonym: "oestrogen catabolic process" EXACT [] synonym: "oestrogen catabolism" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006712 name: mineralocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid breakdown" EXACT [] synonym: "mineralocorticoid catabolism" EXACT [] synonym: "mineralocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006713 name: glucocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid breakdown" EXACT [] synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006715 name: farnesol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] synonym: "farnesol anabolism" EXACT [] synonym: "farnesol biosynthesis" EXACT [] synonym: "farnesol formation" EXACT [] synonym: "farnesol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006716 name: juvenile hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0006717 name: obsolete juvenile hormone binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "juvenile hormone binding" EXACT [] is_obsolete: true consider: GO:0005500 [Term] id: GO:0006718 name: juvenile hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone anabolism" EXACT [] synonym: "juvenile hormone biosynthesis" EXACT [] synonym: "juvenile hormone formation" EXACT [] synonym: "juvenile hormone synthesis" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006719 name: juvenile hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone breakdown" EXACT [] synonym: "juvenile hormone catabolism" EXACT [] synonym: "juvenile hormone degradation" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] xref: MIPS_funcat:01.06 is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0006722 name: triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] synonym: "triterpene metabolic process" NARROW [] synonym: "triterpene metabolism" NARROW [] synonym: "triterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006723 name: cuticle hydrocarbon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] synonym: "cuticle hydrocarbon anabolism" EXACT [] synonym: "cuticle hydrocarbon biosynthesis" EXACT [] synonym: "cuticle hydrocarbon formation" EXACT [] synonym: "cuticle hydrocarbon synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006726 name: eye pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment anabolism" EXACT [] synonym: "eye pigment biosynthesis" EXACT [] synonym: "eye pigment formation" EXACT [] synonym: "eye pigment synthesis" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006727 name: ommochrome biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] synonym: "ommochrome anabolism" EXACT [] synonym: "ommochrome biosynthesis" EXACT [] synonym: "ommochrome formation" EXACT [] synonym: "ommochrome synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0008055 ! ocellus pigment biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046152 ! ommochrome metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006728 name: pteridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] synonym: "pteridine anabolism" EXACT [] synonym: "pteridine biosynthesis" EXACT [] synonym: "pteridine formation" EXACT [] synonym: "pteridine synthesis" EXACT [] synonym: "pterin biosynthesis" NARROW [] synonym: "pterin biosynthetic process" NARROW [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006729 name: tetrahydrobiopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732] synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT [] synonym: "tetrahydrobiopterin anabolism" EXACT [] synonym: "tetrahydrobiopterin biosynthesis" EXACT [] synonym: "tetrahydrobiopterin formation" EXACT [] synonym: "tetrahydrobiopterin synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0006730 name: one-carbon metabolic process namespace: biological_process alt_id: GO:0019753 alt_id: GO:0019754 def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] subset: goslim_pir synonym: "one carbon metabolic process" EXACT [GOC:mah] synonym: "one carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah] synonym: "one-carbon transfer metabolism" EXACT [GOC:mah] xref: MIPS_funcat:01.05 xref: UM-BBD_pathwayID:C1cyc is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006731 name: obsolete coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0006732 consider: GO:0051189 [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] xref: MIPS_funcat:01.07 is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006733 name: oxidoreduction coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] synonym: "oxidoreduction coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006734 name: NADH metabolic process namespace: biological_process def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] synonym: "NAD (reduced) metabolic process" EXACT [] synonym: "NAD (reduced) metabolism" EXACT [] synonym: "NADH metabolism" EXACT [] synonym: "reduced NAD metabolic process" EXACT [] synonym: "reduced NAD metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006735 name: NADH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah] synonym: "NAD (reduced) regeneration" EXACT [] synonym: "reduced NAD regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019674 ! NAD metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006738 name: nicotinamide riboside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] synonym: "N-ribosylnicotinamide catabolic process" EXACT [] synonym: "nicotinamide riboside breakdown" EXACT [] synonym: "nicotinamide riboside catabolism" EXACT [] synonym: "nicotinamide riboside degradation" EXACT [] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0070638 ! pyridine nucleoside catabolic process [Term] id: GO:0006739 name: NADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NAD phosphorylation and dephosphorylation" RELATED [] synonym: "NADP (oxidized) metabolic process" EXACT [] synonym: "NADP (oxidized) metabolism" EXACT [] synonym: "NADP (reduced) metabolic process" EXACT [] synonym: "NADP (reduced) metabolism" EXACT [] synonym: "NADP metabolism" EXACT [] synonym: "NADPH metabolic process" EXACT [] synonym: "NADPH metabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "oxidized NADP metabolic process" EXACT [] synonym: "oxidized NADP metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "reduced NADP metabolic process" EXACT [] synonym: "reduced NADP metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006740 name: NADPH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah] synonym: "NADP (reduced) regeneration" EXACT [] synonym: "reduced NADP regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006739 ! NADP metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006741 name: NADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NADP (oxidized) biosynthesis" EXACT [] synonym: "NADP (oxidized) biosynthetic process" EXACT [] synonym: "NADP (reduced) biosynthesis" EXACT [] synonym: "NADP (reduced) biosynthetic process" EXACT [] synonym: "NADP anabolism" EXACT [] synonym: "NADP biosynthesis" EXACT [] synonym: "NADP formation" EXACT [] synonym: "NADP synthesis" EXACT [] synonym: "NADPH biosynthesis" EXACT [] synonym: "NADPH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "oxidized NADP biosynthesis" EXACT [] synonym: "oxidized NADP biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "reduced NADP biosynthesis" EXACT [] synonym: "reduced NADP biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0006742 name: NADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NADP (oxidized) catabolic process" EXACT [] synonym: "NADP (oxidized) catabolism" EXACT [] synonym: "NADP (reduced) catabolic process" EXACT [] synonym: "NADP (reduced) catabolism" EXACT [] synonym: "NADP breakdown" EXACT [] synonym: "NADP catabolism" EXACT [] synonym: "NADP degradation" EXACT [] synonym: "NADPH catabolic process" EXACT [] synonym: "NADPH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "oxidized NADP catabolic process" EXACT [] synonym: "oxidized NADP catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "reduced NADP catabolic process" EXACT [] synonym: "reduced NADP catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019364 ! pyridine nucleotide catabolic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0006743 name: ubiquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "coenzyme Q metabolic process" EXACT [] synonym: "coenzyme Q metabolism" EXACT [] synonym: "ubiquinone metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:1901661 ! quinone metabolic process [Term] id: GO:0006744 name: ubiquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "coenzyme Q biosynthetic process" EXACT [] synonym: "coenzyme Q10 biosynthesis" NARROW [] synonym: "coenzyme Q10 biosynthetic process" NARROW [] synonym: "coenzyme Q6 biosynthesis" NARROW [] synonym: "coenzyme Q6 biosynthetic process" NARROW [] synonym: "coenzyme Q8 biosynthesis" NARROW [] synonym: "coenzyme Q8 biosynthetic process" NARROW [] synonym: "coenzyme Q9 biosynthesis" NARROW [] synonym: "coenzyme Q9 biosynthetic process" NARROW [] synonym: "ubiquinone anabolism" EXACT [] synonym: "ubiquinone biosynthesis" EXACT [] synonym: "ubiquinone formation" EXACT [] synonym: "ubiquinone synthesis" EXACT [] xref: MetaCyc:UBISYN-PWY xref: MIPS_funcat:01.20.15.03 is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0006746 name: FADH2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [GOC:ai] synonym: "FADH2 metabolism" EXACT [] synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0006747 name: FAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:ai, PMID:20822113] synonym: "FAD anabolism" EXACT [] synonym: "FAD biosynthesis" EXACT [] synonym: "FAD formation" EXACT [] synonym: "FAD synthesis" EXACT [] synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT [] synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0046443 ! FAD metabolic process is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process [Term] id: GO:0006748 name: lipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] synonym: "lipoamide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006749 name: glutathione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732] synonym: "glutathione metabolism" EXACT [] synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006750 name: glutathione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] synonym: "glutathione anabolism" EXACT [] synonym: "glutathione biosynthesis" EXACT [] synonym: "glutathione formation" EXACT [] synonym: "glutathione synthesis" EXACT [] xref: MetaCyc:GLUTATHIONESYN-PWY xref: MIPS_funcat:01.20.37.01 is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006751 name: glutathione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, ISBN:0198506732] synonym: "glutathione breakdown" EXACT [] synonym: "glutathione catabolism" EXACT [] synonym: "glutathione degradation" EXACT [] is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 alt_id: GO:0006759 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006755 name: obsolete carbamoyl phosphate-ADP transphosphorylation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). synonym: "carbamoyl phosphate-ADP transphosphorylation" EXACT [] is_obsolete: true [Term] id: GO:0006756 name: AMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046033 ! AMP metabolic process is_a: GO:0046940 ! nucleoside monophosphate phosphorylation [Term] id: GO:0006757 name: ATP generation from ADP namespace: biological_process def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] synonym: "ADP phosphorylation" EXACT [GOC:dph] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0046031 ! ADP metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006760 name: folic acid-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah] synonym: "folate and derivative metabolic process" EXACT [] synonym: "folate and derivative metabolism" EXACT [] synonym: "folate-containing compound metabolic process" EXACT [] synonym: "folate-containing compound metabolism" EXACT [] synonym: "folic acid and derivative metabolic process" EXACT [] synonym: "folic acid and derivative metabolism" EXACT [] synonym: "folic acid-containing compound metabolism" EXACT [] synonym: "vitamin B9 and derivative metabolic process" EXACT [] synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006761 name: dihydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] synonym: "7,8-dihydrofolate biosynthesis" EXACT [] synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] synonym: "dihydrofolate anabolism" EXACT [] synonym: "dihydrofolate biosynthesis" EXACT [] synonym: "dihydrofolate formation" EXACT [] synonym: "dihydrofolate synthesis" EXACT [] is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046452 ! dihydrofolate metabolic process [Term] id: GO:0006762 name: obsolete dihydrofolate reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrofolate reduction" EXACT [] is_obsolete: true consider: GO:0004146 consider: GO:0046452 [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vitamin metabolism" EXACT [] xref: MIPS_funcat:01.07 is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006767 name: water-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] synonym: "water-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006768 name: biotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732] synonym: "biotin metabolism" EXACT [] synonym: "vitamin B7 metabolic process" EXACT [] synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Wikipedia:Biotin is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006769 name: nicotinamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732] synonym: "niacin metabolic process" RELATED [] synonym: "niacin metabolism" RELATED [] synonym: "nicotinamide metabolism" EXACT [] synonym: "vitamin B3 metabolic process" BROAD [] synonym: "vitamin B3 metabolism" BROAD [] xref: MetaCyc:PWY-5083 is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0006771 name: riboflavin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin metabolism" EXACT [] synonym: "vitamin B2 metabolic process" EXACT [] synonym: "vitamin B2 metabolism" EXACT [] synonym: "vitamin G metabolic process" EXACT [] synonym: "vitamin G metabolism" EXACT [] xref: Wikipedia:Riboflavin is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0006772 name: thiamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] synonym: "thiamin metabolic process" EXACT [] synonym: "thiamin metabolism" EXACT [] synonym: "thiamine metabolism" EXACT [] synonym: "vitamin B1 metabolic process" EXACT [] synonym: "vitamin B1 metabolism" EXACT [] xref: Wikipedia:Thiamine is_a: GO:0042723 ! thiamine-containing compound metabolic process [Term] id: GO:0006774 name: obsolete vitamin B12 reduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "vitamin B12 reduction" EXACT [] is_obsolete: true consider: GO:0009235 consider: GO:0050453 [Term] id: GO:0006775 name: fat-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] synonym: "fat-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006776 name: vitamin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "vitamin A metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0006777 name: Mo-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] synonym: "Mo-molybdopterin cofactor formation" EXACT [] synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] synonym: "Moco biosynthesis" EXACT [] synonym: "Moco biosynthetic process" EXACT [] synonym: "molybdenum cofactor biosynthetic process" RELATED [] xref: MetaCyc:PWY-6823 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: has_part GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex relationship: has_part GO:0061798 ! GTP 3',8'-cyclase activity relationship: has_part GO:0061799 ! cyclic pyranopterin monophosphate synthase activity [Term] id: GO:0006778 name: porphyrin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin metabolic process" RELATED [] synonym: "porphyrin metabolism" RELATED [] xref: Wikipedia:Porphyrin is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006779 name: porphyrin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin anabolism" RELATED [] synonym: "porphyrin biosynthesis" RELATED [] synonym: "porphyrin biosynthetic process" RELATED [] synonym: "porphyrin formation" RELATED [] synonym: "porphyrin synthesis" RELATED [] xref: MIPS_funcat:01.20.19.01 is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006780 name: uroporphyrinogen III biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] synonym: "uroporphyrinogen III anabolism" EXACT [] synonym: "uroporphyrinogen III biosynthesis" EXACT [] synonym: "uroporphyrinogen III formation" EXACT [] synonym: "uroporphyrinogen III synthesis" EXACT [] is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046502 ! uroporphyrinogen III metabolic process [Term] id: GO:0006781 name: succinyl-CoA pathway namespace: biological_process def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "succinyl CoA pathway" EXACT [] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process [Term] id: GO:0006782 name: protoporphyrinogen IX biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism" EXACT [] synonym: "protoporphyrinogen IX biosynthesis" EXACT [] synonym: "protoporphyrinogen IX formation" EXACT [] synonym: "protoporphyrinogen IX synthesis" EXACT [] is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0046501 ! protoporphyrinogen IX metabolic process relationship: part_of GO:0006783 ! heme biosynthetic process [Term] id: GO:0006783 name: heme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] synonym: "haem biosynthesis" EXACT [] synonym: "haem biosynthetic process" EXACT [] synonym: "heme anabolism" EXACT [] synonym: "heme biosynthesis" EXACT [] synonym: "heme formation" EXACT [] synonym: "heme synthesis" EXACT [] xref: MetaCyc:HEMESYN2-PWY is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006784 name: heme a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [GOC:ai] synonym: "haem a biosynthesis" EXACT [] synonym: "haem a biosynthetic process" EXACT [] synonym: "heme a anabolism" EXACT [] synonym: "heme a biosynthesis" EXACT [] synonym: "heme a formation" EXACT [] synonym: "heme a synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0006785 name: heme b biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25, UniPathway:UPA00252] synonym: "haem b biosynthesis" EXACT [] synonym: "haem b biosynthetic process" EXACT [] synonym: "heme b anabolism" EXACT [] synonym: "heme b biosynthesis" EXACT [] synonym: "heme b formation" EXACT [] synonym: "heme b synthesis" EXACT [] synonym: "protoheme biosynthesis" EXACT [] synonym: "protoheme biosynthetic process" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046492 ! heme b metabolic process [Term] id: GO:0006786 name: heme c biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] synonym: "haem c biosynthesis" EXACT [] synonym: "haem c biosynthetic process" EXACT [] synonym: "heme c anabolism" EXACT [] synonym: "heme c biosynthesis" EXACT [] synonym: "heme c formation" EXACT [] synonym: "heme c synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0006787 name: porphyrin-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin breakdown" RELATED [] synonym: "porphyrin catabolic process" RELATED [] synonym: "porphyrin catabolism" RELATED [] synonym: "porphyrin degradation" RELATED [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006788 name: heme oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] synonym: "haem oxidation" EXACT [] is_a: GO:0042168 ! heme metabolic process is_a: GO:0055114 ! oxidation-reduction process relationship: part_of GO:0006787 ! porphyrin-containing compound catabolic process [Term] id: GO:0006789 name: bilirubin conjugation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6] is_a: GO:0006787 ! porphyrin-containing compound catabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: MIPS_funcat:01.02 xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006791 name: sulfur utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] synonym: "sulphur utilization" EXACT [] xref: MIPS_funcat:01.02.01 is_a: GO:0008150 ! biological_process relationship: has_part GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0006792 name: regulation of sulfur utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] synonym: "regulation of sulphur utilization" EXACT [] xref: MIPS_funcat:01.02.04 xref: MIPS_funcat:01.02.04.03 is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006791 ! sulfur utilization relationship: regulates GO:0006791 ! sulfur utilization [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006794 name: phosphorus utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] xref: MIPS_funcat:01.04.01 is_a: GO:0008150 ! biological_process relationship: has_part GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006795 name: regulation of phosphorus utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] xref: MIPS_funcat:01.04.04 is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006794 ! phosphorus utilization relationship: regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] xref: MIPS_funcat:01.04 is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006797 name: polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] synonym: "polyphosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0006798 name: polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] synonym: "polyphosphate breakdown" EXACT [] synonym: "polyphosphate catabolism" EXACT [] synonym: "polyphosphate degradation" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0006799 name: polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732] synonym: "polyphosphate anabolism" EXACT [] synonym: "polyphosphate biosynthesis" EXACT [] synonym: "polyphosphate formation" EXACT [] synonym: "polyphosphate synthesis" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0006800 name: obsolete oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "oxygen and active oxygen species metabolism" EXACT [] synonym: "oxygen and AOS metabolism" EXACT [] synonym: "oxygen and reactive oxidative species metabolism" EXACT [] synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] synonym: "oxygen and reactive oxygen species metabolic process" EXACT [] synonym: "oxygen and reactive oxygen species metabolism" EXACT [] synonym: "oxygen and ROI metabolism" EXACT [] synonym: "oxygen and ROS metabolic process" EXACT [] synonym: "oxygen and ROS metabolism" EXACT [] is_obsolete: true consider: GO:0072592 consider: GO:0072593 [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl] synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] xref: MIPS_funcat:32.07.07.07 is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0006802 name: obsolete catalase reaction namespace: biological_process def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] comment: This term was made obsolete because it represents a molecular function. synonym: "catalase reaction" EXACT [] synonym: "hydroperoxidase reaction" RELATED [] is_obsolete: true consider: GO:0004096 [Term] id: GO:0006803 name: obsolete glutathione conjugation reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "glutathione conjugation reaction" EXACT [] is_obsolete: true replaced_by: GO:0004364 [Term] id: GO:0006804 name: obsolete peroxidase reaction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "peroxidase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004601 [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "xenobiotic metabolism" EXACT [] xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus [Term] id: GO:0006806 name: obsolete insecticide resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "insecticide resistance" EXACT [] is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] xref: MIPS_funcat:01.02 is_a: GO:0008152 ! metabolic process [Term] id: GO:0006808 name: regulation of nitrogen utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] subset: goslim_metagenomics xref: MIPS_funcat:01.02.04 xref: MIPS_funcat:01.02.04.01 is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019740 ! nitrogen utilization relationship: regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0006809 name: nitric oxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] xref: MIPS_funcat:01.02.01.07 is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] xref: MIPS_funcat:20 is_a: GO:0051234 ! establishment of localization created_by: janelomax creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast xref: MIPS_funcat:20.01.01 is_a: GO:0006810 ! transport [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] xref: MIPS_funcat:20.01.01.01 is_a: GO:0006811 ! ion transport [Term] id: GO:0006813 name: potassium ion transport namespace: biological_process alt_id: GO:0015458 alt_id: GO:0071804 def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cellular potassium ion transport" EXACT [] synonym: "K+ conductance" RELATED [] synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "potassium conductance" NARROW [] synonym: "potassium ion conductance" NARROW [] synonym: "potassium transport" RELATED [] synonym: "sodium/potassium transport" BROAD [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport created_by: midori creation_date: 2010-09-03T02:39:22Z [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006815 name: obsolete sodium/potassium transport namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "sodium/potassium transport" EXACT [] is_obsolete: true consider: GO:0006813 consider: GO:0006814 [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006817 name: phosphate ion transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "phosphate transport" RELATED [] xref: MIPS_funcat:20.01.01.07.07 is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: MIPS_funcat:20.01.01.07 is_a: GO:0006811 ! ion transport [Term] id: GO:0006821 name: chloride transport namespace: biological_process def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] xref: MIPS_funcat:20.01.01.07.09 is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006823 name: obsolete heavy metal ion transport namespace: biological_process def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal ion transport" EXACT [] is_obsolete: true consider: GO:0030001 [Term] id: GO:0006824 name: cobalt ion transport namespace: biological_process def: "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cobalt transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport [Term] id: GO:0006825 name: copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006826 name: iron ion transport namespace: biological_process alt_id: GO:0015681 alt_id: GO:0015682 alt_id: GO:0015684 alt_id: GO:0033216 alt_id: GO:0097286 def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "ferric ion import" NARROW [] synonym: "ferric ion transport" NARROW [] synonym: "ferric iron import" NARROW [] synonym: "ferric iron transport" NARROW [] synonym: "ferric iron uptake" NARROW [] synonym: "ferrous ion transport" NARROW [] synonym: "ferrous iron transport" NARROW [] synonym: "iron ion import" RELATED [] synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport created_by: paola creation_date: 2012-04-18T03:33:45Z [Term] id: GO:0006828 name: manganese ion transport namespace: biological_process def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006829 name: zinc ion transport namespace: biological_process def: "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "zinc II ion transport" EXACT [] synonym: "zinc transport" EXACT [GOC:mah] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006832 name: obsolete small molecule transport namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "small molecule transport" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0006833 name: water transport namespace: biological_process def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0042044 ! fluid transport [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] xref: MIPS_funcat:20.01.26 is_a: GO:0006810 ! transport [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0006838 name: obsolete allantoin/allantoate transport namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "allantoin/allantoate transport" EXACT [] is_obsolete: true consider: GO:0015719 consider: GO:0015720 [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] subset: goslim_drosophila synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] synonym: "mitochondrial aspartate/glutamate transport" NARROW [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] xref: MIPS_funcat:20.09.04 is_a: GO:0006810 ! transport [Term] id: GO:0006840 name: obsolete mitochondrial alpha-ketoglutarate/malate transport namespace: biological_process def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial alpha-ketoglutarate/malate transport" EXACT [] synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] is_obsolete: true consider: GO:0006839 consider: GO:0015367 consider: GO:0015742 consider: GO:0015743 [Term] id: GO:0006842 name: tricarboxylic acid transport namespace: biological_process def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006843 name: mitochondrial citrate transmembrane transport namespace: biological_process alt_id: GO:1990541 def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix." [GOC:ai, PMID:20371607] synonym: "mitochondrial citrate transport" RELATED [] is_a: GO:0015746 ! citrate transport is_a: GO:1990546 ! mitochondrial tricarboxylic acid transmembrane transport created_by: vw creation_date: 2014-11-19T11:08:45Z [Term] id: GO:0006844 name: acyl carnitine transport namespace: biological_process def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0006845 name: obsolete mitochondrial aspartate/glutamate transport namespace: biological_process def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial aspartate/glutamate transport" EXACT [] is_obsolete: true consider: GO:0006839 consider: GO:0015810 consider: GO:0015813 [Term] id: GO:0006846 name: acetate transport namespace: biological_process def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006847 name: plasma membrane acetate transport namespace: biological_process def: "The directed movement of acetate across a plasma membrane." [GOC:ai] is_a: GO:0035433 ! acetate transmembrane transport [Term] id: GO:0006848 name: pyruvate transport namespace: biological_process def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006849 name: plasma membrane pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] is_a: GO:1901475 ! pyruvate transmembrane transport [Term] id: GO:0006850 name: mitochondrial pyruvate transmembrane transport namespace: biological_process alt_id: GO:1902361 def: "The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558] synonym: "mitochondrial pyruvate transport" RELATED [] synonym: "pyruvate membrane transport in mitochondria" RELATED [] synonym: "pyruvate membrane transport in mitochondrion" RELATED [] synonym: "pyruvate transmembrane transport in mitochondria" RELATED [] synonym: "pyruvate transmembrane transport in mitochondrion" RELATED [] is_a: GO:1901475 ! pyruvate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: dph creation_date: 2013-08-15T11:19:35Z [Term] id: GO:0006851 name: mitochondrial calcium ion transmembrane transport namespace: biological_process def: "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai] synonym: "mitochondrial calcium transport" EXACT [] is_a: GO:0070588 ! calcium ion transmembrane transport [Term] id: GO:0006852 name: obsolete mitochondrial sodium/calcium ion exchange namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents function rather than a process. synonym: "mitochondrial sodium/calcium exchange" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" EXACT [] is_obsolete: true consider: GO:0005432 consider: GO:0006814 consider: GO:0006816 consider: GO:0006839 [Term] id: GO:0006853 name: carnitine shuttle namespace: biological_process def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0032365 ! intracellular lipid transport is_a: GO:1902001 ! fatty acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0006854 name: obsolete ATP/ADP exchange namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "ATP/ADP exchange" EXACT [] is_obsolete: true replaced_by: GO:0005471 [Term] id: GO:0006855 name: drug transmembrane transport namespace: biological_process def: "The process in which a drug is transported across a membrane." [GOC:ai, GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "drug membrane transport" EXACT [] synonym: "multidrug transport" RELATED [] is_a: GO:0015893 ! drug transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0006856 name: eye pigment precursor transport namespace: biological_process def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006810 ! transport relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0006857 name: oligopeptide transport namespace: biological_process def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732] is_a: GO:0015833 ! peptide transport [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006859 name: extracellular carbohydrate transport namespace: biological_process def: "The directed extracellular movement of carbohydrates." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0008643 ! carbohydrate transport intersection_of: GO:0008643 ! carbohydrate transport intersection_of: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport intersection_of: GO:0006865 ! amino acid transport intersection_of: occurs_in GO:0005576 ! extracellular region [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732] xref: MIPS_funcat:20.01.17 is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0006863 name: purine nucleobase transport namespace: biological_process alt_id: GO:0015852 def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "purine base transmembrane transport" EXACT [GOC:mah] synonym: "purine base transport" EXACT [GOC:go_curators] synonym: "purine transmembrane transport" RELATED [GOC:mah] synonym: "purine transport" RELATED [] is_a: GO:0015851 ! nucleobase transport [Term] id: GO:0006864 name: pyrimidine nucleotide transport namespace: biological_process def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast xref: MIPS_funcat:20.01.07 is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0006867 name: asparagine transport namespace: biological_process def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-asparagine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0042886 ! amide transport [Term] id: GO:0006868 name: glutamine transport namespace: biological_process alt_id: GO:0015815 def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-glutamine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast xref: MIPS_funcat:20.01.13 is_a: GO:0071702 ! organic substance transport relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006873 name: cellular ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah] subset: goslim_yeast xref: MIPS_funcat:34.01 is_a: GO:0050801 ! ion homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0006874 name: cellular calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055074 ! calcium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006875 name: cellular metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cellular heavy metal ion homeostasis" NARROW [] xref: MIPS_funcat:34.01.01.01 is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0006876 name: cellular cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cadmium homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055073 ! cadmium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006877 name: cellular cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055068 ! cobalt ion homeostasis [Term] id: GO:0006878 name: cellular copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "copper homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055070 ! copper ion homeostasis [Term] id: GO:0006879 name: cellular iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "iron homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055072 ! iron ion homeostasis [Term] id: GO:0006880 name: intracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] synonym: "intracellular iron ion retention" EXACT [] synonym: "intracellular iron ion sequestering" EXACT [] synonym: "intracellular iron ion sequestration" EXACT [] synonym: "intracellular iron ion storage" EXACT [] synonym: "intracellular retention of iron ion" EXACT [] synonym: "intracellular sequestration of iron ion" EXACT [] synonym: "intracellular storage of iron ion" EXACT [] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0097577 ! sequestering of iron ion [Term] id: GO:0006881 name: extracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai, GOC:cjm] synonym: "extracellular iron ion retention" EXACT [] synonym: "extracellular iron ion sequestering" EXACT [] synonym: "extracellular iron ion sequestration" EXACT [] synonym: "extracellular iron ion storage" EXACT [] synonym: "extracellular retention of iron ion" EXACT [] synonym: "extracellular sequestration of iron ion" EXACT [] synonym: "extracellular storage of iron ion" EXACT [] is_a: GO:0097577 ! sequestering of iron ion [Term] id: GO:0006882 name: cellular zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055069 ! zinc ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006883 name: cellular sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis [Term] id: GO:0006884 name: cell volume homeostasis namespace: biological_process def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0008361 ! regulation of cell size is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0006885 name: regulation of pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: MIPS_funcat:20.09.16.09 xref: MIPS_funcat:20.09.16.09.03 xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell relationship: has_part GO:0099500 ! vesicle fusion to plasma membrane [Term] id: GO:0006888 name: endoplasmic reticulum to Golgi vesicle-mediated transport namespace: biological_process alt_id: GO:0048221 def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] synonym: "anterograde (ER to Golgi) transport" EXACT [] synonym: "anterograde transport, endoplasmic reticulum to Golgi" EXACT [] synonym: "anterograde transport, ER to Golgi" EXACT [] synonym: "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi" EXACT [] synonym: "anterograde vesicle-mediated transport, ER to Golgi" EXACT [] synonym: "endoplasmic reticulum to Golgi transport" EXACT [] synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [] synonym: "ER to Golgi transport" EXACT [] synonym: "ER to Golgi vesicle-mediated transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] synonym: "rough ER to cis-Golgi transport" EXACT [] synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT [] xref: MIPS_funcat:20.09.07.03 is_a: GO:0046907 ! intracellular transport is_a: GO:0048193 ! Golgi vesicle transport relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0006889 name: obsolete regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). synonym: "regulation of calcium in ER" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0006890 name: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum namespace: biological_process alt_id: GO:0048220 def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] synonym: "cis-Golgi to rough ER transport" EXACT [] synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT [] synonym: "retrograde (Golgi to ER) transport" EXACT [] synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] synonym: "retrograde transport, Golgi to ER" EXACT [] synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [] synonym: "retrograde vesicle-mediated transport, Golgi to ER" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006891 name: intra-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] synonym: "intra-Golgi transport" EXACT [] xref: MIPS_funcat:20.09.07.05 is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: MIPS_funcat:20.09.07.06 is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane [Term] id: GO:0006894 name: obsolete Golgi to secretory vesicle transport namespace: biological_process def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. synonym: "Golgi to secretory vesicle transport" EXACT [] synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] is_obsolete: true consider: GO:0055107 consider: GO:0055108 [Term] id: GO:0006895 name: Golgi to endosome transport namespace: biological_process alt_id: GO:0048218 def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] synonym: "TGN to endosome transport" EXACT [] synonym: "trans-Golgi to endosome transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 alt_id: GO:0098701 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] subset: goslim_yeast synonym: "endocytic import into cell" EXACT [] synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" NARROW [] synonym: "vesicle endocytosis" EXACT [] xref: MIPS_funcat:20.09.18.09.01 xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: has_part GO:0006900 ! vesicle budding from membrane relationship: has_part GO:0010324 ! membrane invagination [Term] id: GO:0006898 name: receptor-mediated endocytosis namespace: biological_process def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] synonym: "receptor mediated endocytosis" EXACT [] xref: MIPS_funcat:20.09.18.09.01.01 xref: Wikipedia:Receptor-mediated_endocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process alt_id: GO:0006902 alt_id: GO:1902591 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] xref: MIPS_funcat:20.09.07.25 is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: jl creation_date: 2013-12-19T15:26:17Z [Term] id: GO:0006901 name: vesicle coating namespace: biological_process def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] synonym: "vesicle coat assembly" BROAD [] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0006900 ! vesicle budding from membrane [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006904 name: vesicle docking involved in exocytosis namespace: biological_process def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915] synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048278 ! vesicle docking is_a: GO:0140029 ! exocytic process intersection_of: GO:0048278 ! vesicle docking intersection_of: part_of GO:0006887 ! exocytosis [Term] id: GO:0006905 name: obsolete vesicle transport namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "vesicle transport" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] xref: MIPS_funcat:20.09.07.27 is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006907 name: pinocytosis namespace: biological_process alt_id: GO:0006908 alt_id: GO:1902536 def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane." [ISBN:0198506732] synonym: "clathrin-independent pinocytosis" BROAD [] synonym: "fluid-phase endocytosis" EXACT [] synonym: "single-organism pinocytosis" RELATED [] xref: Wikipedia:Pinocytosis is_a: GO:0006897 ! endocytosis created_by: jl creation_date: 2013-12-02T14:14:38Z [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] xref: MIPS_funcat:36.25.16.01.03 xref: Wikipedia:Phagocytosis is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006910 name: phagocytosis, recognition namespace: biological_process def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149] comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] is_a: GO:0008037 ! cell recognition intersection_of: GO:0008037 ! cell recognition intersection_of: part_of GO:0006909 ! phagocytosis relationship: has_part GO:0038024 ! cargo receptor activity relationship: part_of GO:0006897 ! endocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006911 name: phagocytosis, engulfment namespace: biological_process def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] synonym: "phagosome biosynthesis" RELATED [] synonym: "phagosome formation" RELATED [] is_a: GO:0099024 ! plasma membrane invagination intersection_of: GO:0099024 ! plasma membrane invagination intersection_of: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0006897 ! endocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006912 name: obsolete phagosome formation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because of the ambiguity in its meaning. synonym: "phagosome formation" EXACT [] is_obsolete: true consider: GO:0001845 consider: GO:0006911 [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process is_a: GO:0061919 ! process utilizing autophagic mechanism [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] subset: goslim_pombe synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: MIPS_funcat:40.10.02 xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006918 name: obsolete induction of apoptosis by p53 namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. synonym: "induction of apoptosis by p53" EXACT [] is_obsolete: true consider: GO:0006915 [Term] id: GO:0006919 name: activation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase. synonym: "activation of caspase activity" NARROW [] synonym: "activation of metacaspase activity" NARROW [] synonym: "caspase activation" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:40.10.02.02.02 is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0006920 name: obsolete commitment to apoptosis namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. synonym: "commitment to apoptosis" EXACT [] is_obsolete: true consider: GO:0006915 [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] xref: MIPS_funcat:40.10.02.02.03 is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: part_of GO:0097194 ! execution phase of apoptosis relationship: part_of GO:0097194 ! execution phase of apoptosis [Term] id: GO:0006922 name: obsolete cleavage of lamin involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, GOC:mtg_apoptosis, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "cleavage of lamin" BROAD [] synonym: "cleavage of lamin involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0006923 name: obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] synonym: "cleavage of cytoskeletal proteins involved in apoptosis" BROAD [] synonym: "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0006924 name: activation-induced cell death of T cells namespace: biological_process def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "AICD" BROAD [GOC:add] synonym: "antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0070231 ! T cell apoptotic process relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0006925 name: inflammatory cell apoptotic process namespace: biological_process def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis, http://www.mercksource.com/] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell apoptosis" NARROW [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006926 name: obsolete virus-infected cell apoptotic process namespace: biological_process def: "OBSOLETE. Any apoptotic process in a cell infected with a virus." [GOC:jl, GOC:mtg_apoptosis] comment: This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral process terms to annotate viral proteins. As for the cellular apoptotic process, this likely occurs via the same mechanisms described by existing apoptotic process terms, so please consider using those to annotate cellular proteins. synonym: "apoptosis of virus-infected cells" EXACT [] synonym: "killing virus-infected cells" EXACT [] synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] synonym: "programmed cell death, virus-infected cells" EXACT [] synonym: "virus-infected cell apoptosis" NARROW [] synonym: "virus-infected cell apoptotic process" EXACT [] synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0006927 name: obsolete transformed cell apoptotic process namespace: biological_process def: "OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, GOC:mtg_apoptosis] comment: This term was made obsolete because it does not refer to a normal process. synonym: "apoptosis of transformed cells" EXACT [] synonym: "killing transformed cells" EXACT [] synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] synonym: "programmed cell death, transformed cells" EXACT [] synonym: "transformed cell apoptosis" NARROW [] synonym: "transformed cell programmed cell death by apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0006928 name: movement of cell or subcellular component namespace: biological_process def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] synonym: "cellular component movement" EXACT [] xref: MIPS_funcat:02.45.11 xref: MIPS_funcat:34.05 is_a: GO:0009987 ! cellular process [Term] id: GO:0006929 name: substrate-dependent cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0006930 name: substrate-dependent cell migration, cell extension namespace: biological_process def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell extension" EXACT [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006931 name: substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT [] is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006932 name: substrate-dependent cell migration, cell contraction namespace: biological_process def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell contraction" EXACT [] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility relationship: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006933 name: negative regulation of cell adhesion involved in substrate-bound cell migration namespace: biological_process def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion intersection_of: GO:0007162 ! negative regulation of cell adhesion intersection_of: part_of GO:0006929 ! substrate-dependent cell migration relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006934 name: substrate-bound cell migration, adhesion receptor recycling namespace: biological_process def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] synonym: "taxis in response to chemical stimulus" EXACT [] xref: MIPS_funcat:34.11.03.03 xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] subset: goslim_pir xref: MIPS_funcat:36.25.09 xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] xref: MIPS_funcat:36.25.09.05 is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006936 ! muscle contraction relationship: regulates GO:0006936 ! muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "visceral muscle contraction" EXACT [] xref: MIPS_funcat:36.25.09.01 is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006939 ! smooth muscle contraction relationship: regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "sarcomeric muscle contraction" EXACT [] xref: MIPS_funcat:36.25.09.03 is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006941 ! striated muscle contraction relationship: regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0006943 name: obsolete chemi-mechanical coupling namespace: biological_process def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com] comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. synonym: "chemi-mechanical coupling" EXACT [] synonym: "mechanochemical coupling" EXACT [] is_obsolete: true consider: GO:0009612 consider: GO:0050954 [Term] id: GO:0006945 name: obsolete nuclear fusion during karyogamy namespace: biological_process def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. synonym: "nuclear fusion during karyogamy" EXACT [] is_obsolete: true consider: GO:0000741 [Term] id: GO:0006948 name: induction by virus of host cell-cell fusion namespace: biological_process def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] comment: Where syncytium formation results in the spread of virus in the host, also consider annotating to the term 'spread of virus in multicellular host ; GO:0046739'. synonym: "induction by virus of cell-cell fusion in host" EXACT [] synonym: "viral-induced cell-cell fusion" EXACT [] synonym: "viral-induced host cell-cell fusion" EXACT [] synonym: "viral-induced membrane fusion" NARROW [] is_a: GO:0019054 ! modulation by virus of host cellular process [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] xref: MIPS_funcat:32.01 is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006953 name: acute-phase response namespace: biological_process def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732] xref: MIPS_funcat:36.25.16.01.07 is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "Inflammation" BROAD [] xref: MIPS_funcat:36.25.16.07 xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was redefined and moved. subset: goslim_drosophila xref: MIPS_funcat:36.25.16 is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006956 name: complement activation namespace: biological_process def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "complement activity" RELATED [] synonym: "complement cascade" EXACT [GOC:add] synonym: "complement response" EXACT [] xref: MIPS_funcat:36.25.16.01.01 is_a: GO:0002252 ! immune effector process is_a: GO:0002253 ! activation of immune response is_a: GO:0006959 ! humoral immune response relationship: has_part GO:0072376 ! protein activation cascade [Term] id: GO:0006957 name: complement activation, alternative pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] synonym: "complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0006958 name: complement activation, classical pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149] synonym: "complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0006959 name: humoral immune response namespace: biological_process def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] xref: Wikipedia:Humoral_immunity is_a: GO:0006955 ! immune response [Term] id: GO:0006962 name: male-specific antibacterial humoral response namespace: biological_process def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] is_a: GO:0019731 ! antibacterial humoral response is_a: GO:0050831 ! male-specific defense response to bacterium [Term] id: GO:0006963 name: positive regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] synonym: "antibacterial peptide induction" EXACT [] synonym: "antibacterial polypeptide induction" EXACT [] synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] is_a: GO:0002803 ! positive regulation of antibacterial peptide production is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0006964 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0006965 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0006967 name: positive regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] synonym: "activation of antifungal peptide biosynthetic process" NARROW [] synonym: "antifungal peptide induction" EXACT [] synonym: "antifungal polypeptide induction" EXACT [] synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] is_a: GO:0002804 ! positive regulation of antifungal peptide production is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0006968 name: cellular defense response namespace: biological_process alt_id: GO:0016066 alt_id: GO:0016067 def: "A defense response that is mediated by cells." [GOC:ebc] comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes. synonym: "cellular defence response" EXACT [] is_a: GO:0006952 ! defense response [Term] id: GO:0006969 name: obsolete melanotic tumor response namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it was undefined and represented an abnormal process. synonym: "melanotic mass response" EXACT [] synonym: "melanotic tumor response" EXACT [] is_obsolete: true [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: goslim_yeast synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] xref: MIPS_funcat:32.01.03 xref: MIPS_funcat:36.20.35.09.05 is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0006971 name: hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593] synonym: "hypo-osmotic response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006973 name: intracellular accumulation of glycerol namespace: biological_process def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] is_a: GO:0019725 ! cellular homeostasis relationship: part_of GO:0071474 ! cellular hyperosmotic response [Term] id: GO:0006974 name: cellular response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: goslim_yeast synonym: "cellular DNA damage response" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to DNA damage stimulus" BROAD [] synonym: "response to genotoxic stress" EXACT [] xref: MIPS_funcat:32.01.09 is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0006975 name: DNA damage induced protein phosphorylation namespace: biological_process def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0006974 ! cellular response to DNA damage stimulus [Term] id: GO:0006977 name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0071158 ! positive regulation of cell cycle arrest is_a: GO:0072431 ! signal transduction involved in mitotic G1 DNA damage checkpoint [Term] id: GO:0006978 name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: goslim_yeast xref: MIPS_funcat:32.01.01 is_a: GO:0006950 ! response to stress [Term] id: GO:0006981 name: obsolete activation of SoxR protein namespace: biological_process def: "OBSOLETE. The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] comment: This term was made obsolete because it was too specific with respect to a single gene product. is_obsolete: true [Term] id: GO:0006982 name: response to lipid hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] synonym: "response to LHPO" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0006983 name: ER overload response namespace: biological_process alt_id: GO:0006985 def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] synonym: "endoplasmic reticulum overload response" EXACT [] synonym: "EOR" EXACT [] synonym: "EOR-mediated activation of NF-kappaB" NARROW [GOC:dph, GOC:tb] synonym: "EOR-mediated NF-kappaB activation" NARROW [] synonym: "ER-overload response" EXACT [] synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of NF-kappaB transcription factor activity by ER overload response" NARROW [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0006984 name: ER-nucleus signaling pathway namespace: biological_process def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] synonym: "ER to nucleus signaling pathway" EXACT [] synonym: "ER to nucleus signalling pathway" EXACT [] synonym: "ER-nuclear signaling pathway" EXACT [] synonym: "ER-nuclear signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0006986 name: response to unfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. synonym: "heat shock protein activity" RELATED [] is_a: GO:0035966 ! response to topologically incorrect protein [Term] id: GO:0006987 name: obsolete activation of signaling protein activity involved in unfolded protein response namespace: biological_process def: "OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] is_obsolete: true consider: GO:0036498 [Term] id: GO:0006988 name: obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" EXACT [] is_obsolete: true consider: GO:0004521 [Term] id: GO:0006989 name: obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" EXACT [] is_obsolete: true consider: GO:0008452 [Term] id: GO:0006990 name: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response namespace: biological_process def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763] synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of target gene transcription" NARROW [] synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006991 name: response to sterol depletion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732] synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb] is_a: GO:0006950 ! response to stress [Term] id: GO:0006995 name: cellular response to nitrogen starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043562 ! cellular response to nitrogen levels [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.10 is_a: GO:0006996 ! organelle organization [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.10.05 is_a: GO:0061024 ! membrane organization relationship: part_of GO:0006997 ! nucleus organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0006999 name: nuclear pore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear pore organisation" EXACT [] synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.10.07 is_a: GO:0006997 ! nucleus organization [Term] id: GO:0007002 name: obsolete centromere binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "centromere binding" EXACT [] is_obsolete: true replaced_by: GO:0019237 [Term] id: GO:0007003 name: obsolete telomere binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "telomere binding" EXACT [] is_obsolete: true replaced_by: GO:0042162 [Term] id: GO:0007004 name: telomere maintenance via telomerase namespace: biological_process def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] synonym: "telomerase-dependent telomere maintenance" EXACT [] is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process is_a: GO:0010833 ! telomere maintenance via telomere lengthening relationship: has_part GO:0003720 ! telomerase activity relationship: has_part GO:1905324 ! telomere-telomerase complex assembly [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [] xref: MIPS_funcat:42.16 is_a: GO:0006996 ! organelle organization [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0007007 name: inner mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "inner mitochondrial membrane organisation" EXACT [] synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] synonym: "mitochondrial inner membrane organization" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.02 is_a: GO:0061024 ! membrane organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.04 is_a: GO:0006996 ! organelle organization [Term] id: GO:0007011 name: obsolete regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. synonym: "regulation of cytoskeleton" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0007014 name: actin ubiquitination namespace: biological_process def: "The modification of actin by addition of ubiquitin groups." [GOC:mah] synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0030047 ! actin modification [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0097435 ! supramolecular fiber organization relationship: part_of GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0007016 name: cytoskeletal anchoring at plasma membrane namespace: biological_process def: "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] synonym: "cytoskeletal anchoring activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] xref: MIPS_funcat:20.09.14.01 is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] synonym: "microtubule shortening" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0046785 ! microtubule polymerization [Term] id: GO:0007021 name: tubulin complex assembly namespace: biological_process def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] synonym: "tubulin assembly" EXACT [] synonym: "tubulin folding" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0007023 name: post-chaperonin tubulin folding pathway namespace: biological_process def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] is_a: GO:0006457 ! protein folding [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007019 ! microtubule depolymerization relationship: negatively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.03 is_a: GO:0016043 ! cellular component organization [Term] id: GO:0007029 name: endoplasmic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endoplasmic reticulum morphology" RELATED [] synonym: "endoplasmic reticulum organisation" EXACT [] synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] synonym: "ER organisation" EXACT [] synonym: "ER organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.07 is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi organisation" EXACT [] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.08 is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] xref: MIPS_funcat:42.19 is_a: GO:0006996 ! organelle organization [Term] id: GO:0007032 name: endosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endosome organisation" EXACT [] synonym: "endosome organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.22 is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.25 is_a: GO:0006996 ! organelle organization [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl subset: goslim_generic xref: MIPS_funcat:20.09.13 is_a: GO:0006810 ! transport [Term] id: GO:0007035 name: vacuolar acidification namespace: biological_process def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole [Term] id: GO:0007038 name: endocytosed protein transport to vacuole namespace: biological_process def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] comment: See also the biological process term 'endocytosis ; GO:0006897'. synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] is_a: GO:0007034 ! vacuolar transport is_a: GO:0015031 ! protein transport [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] xref: MIPS_funcat:14.13.04 xref: MIPS_funcat:14.13.04.02 is_a: GO:0044257 ! cellular protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] synonym: "lysosome organisation" EXACT [] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.25 is_a: GO:0080171 ! lytic vacuole organization [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007042 name: lysosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph] is_a: GO:0007035 ! vacuolar acidification is_a: GO:0035751 ! regulation of lysosomal lumen pH [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] xref: MIPS_funcat:42.06 xref: MIPS_funcat:42.06.04 is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0007044 name: cell-substrate junction assembly namespace: biological_process alt_id: GO:0007045 def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] comment: The primary label for merged term was 'cell-substrate adherens junction assembly' GO:0007045. The term was merged into the parent 'cell-substrate junction assembly', because, based on the most recent litarature, 'adherens junction' is always a 'cell-cell junction' (PMIDs: 20571587, 17854762, 21422226, 28096264, 28401269, 26923917). synonym: "cell-substrate adherens junction assembly" RELATED [] xref: MIPS_funcat:42.06.03 is_a: GO:0034329 ! cell junction assembly is_a: GO:0150115 ! cell-substrate junction organization [Term] id: GO:0007048 name: obsolete oncogenesis namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a pathological process. synonym: "oncogenesis" EXACT [] is_obsolete: true [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: MIPS_funcat:10 xref: MIPS_funcat:10.03 xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007050 name: cell cycle arrest namespace: biological_process def: "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] xref: MIPS_funcat:10.03.01.02 is_a: GO:0022402 ! cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0007051 name: spindle organization namespace: biological_process alt_id: GO:0043146 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] synonym: "spindle organisation" EXACT [] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle stabilization" RELATED [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process alt_id: GO:0000071 alt_id: GO:0030472 alt_id: GO:0043148 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] comment: In fission yeast most mitotic spindle organization occurs in the nucleus; see https://github.com/geneontology/go-ontology/issues/15341. synonym: "mitotic spindle organisation" EXACT [] synonym: "mitotic spindle organisation in nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW [] synonym: "mitotic spindle organization in nucleus" NARROW [] synonym: "mitotic spindle stabilization" RELATED [] synonym: "spindle organization and biogenesis during mitosis" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW [] is_a: GO:0007051 ! spindle organization is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007054 name: spindle assembly involved in male meiosis I namespace: biological_process def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis I spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007141 ! male meiosis I relationship: part_of GO:0007141 ! male meiosis I [Term] id: GO:0007055 name: spindle assembly involved in male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis II spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007142 ! male meiosis II relationship: part_of GO:0007142 ! male meiosis II [Term] id: GO:0007056 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiotic spindle assembly" RELATED [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007057 name: spindle assembly involved in female meiosis I namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis I spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007144 ! female meiosis I relationship: part_of GO:0007144 ! female meiosis I [Term] id: GO:0007058 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis II spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007147 ! female meiosis II relationship: part_of GO:0007147 ! female meiosis II [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: MIPS_funcat:10.03.04 xref: MIPS_funcat:10.03.04.05 xref: Wikipedia:Chromosome_segregation is_a: GO:0009987 ! cellular process [Term] id: GO:0007060 name: male meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007062 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194] synonym: "coheson-mediated DNA tethering" EXACT [] synonym: "sister chromatid alignment" RELATED [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0000819 ! sister chromatid segregation [Term] id: GO:0007063 name: regulation of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007062 ! sister chromatid cohesion relationship: regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0007064 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0007062 ! sister chromatid cohesion intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007065 name: male meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007066 name: female meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007068 name: obsolete negative regulation of transcription during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription" EXACT [] synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007069 name: obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007070 name: obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007071 name: obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007072 name: positive regulation of transcription involved in exit from mitosis namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0010458 ! exit from mitosis relationship: part_of GO:0010458 ! exit from mitosis [Term] id: GO:0007073 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007074 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007075 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" EXACT [] synonym: "mitotic nuclear envelope degradation" EXACT [] is_a: GO:0051081 ! nuclear envelope disassembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051081 ! nuclear envelope disassembly intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007078 name: lamin depolymerization namespace: biological_process def: "The cell cycle process in which lamin is depolymerized." [GOC:jid] is_a: GO:0051261 ! protein depolymerization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly [Term] id: GO:0007079 name: mitotic chromosome movement towards spindle pole namespace: biological_process alt_id: GO:0007082 def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] synonym: "chromosome migration to spindle pole during mitosis" EXACT [] synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] synonym: "mitotic chromosome movement" BROAD [] synonym: "mitotic chromosome movement to spindle pole" EXACT [] synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] is_a: GO:0051305 ! chromosome movement towards spindle pole is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051305 ! chromosome movement towards spindle pole intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007080 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] is_a: GO:0051310 ! metaphase plate congression is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051310 ! metaphase plate congression intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007081 name: obsolete mitotic sister-chromatid adhesion release namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. synonym: "mitotic sister-chromatid adhesion release" EXACT [] is_obsolete: true consider: GO:0000070 consider: GO:0007064 [Term] id: GO:0007083 name: mitotic chromosome decondensation namespace: biological_process def: "The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] is_a: GO:0051312 ! chromosome decondensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051312 ! chromosome decondensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007084 name: mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division." [GOC:ai] is_a: GO:0031468 ! nuclear envelope reassembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0031468 ! nuclear envelope reassembly intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007085 name: obsolete nuclear membrane vesicle binding to chromatin namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "nuclear membrane vesicle binding to chromatin" EXACT [] is_obsolete: true consider: GO:0003682 [Term] id: GO:0007086 name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah] is_a: GO:0000740 ! nuclear membrane fusion is_a: GO:0006906 ! vesicle fusion is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007087 name: mitotic nuclear pore complex reassembly namespace: biological_process def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai] is_a: GO:0051292 ! nuclear pore complex assembly is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140014 ! mitotic nuclear division relationship: regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0007089 name: traversing start control point of mitotic cell cycle namespace: biological_process alt_id: GO:0000081 def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle] is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle [Term] id: GO:0007090 name: obsolete regulation of S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "regulation of S phase of mitotic cell cycle" EXACT [] synonym: "regulation of S-phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0044772 [Term] id: GO:0007091 name: metaphase/anaphase transition of mitotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] synonym: "mitotic metaphase/anaphase transition" EXACT [] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007093 name: mitotic cell cycle checkpoint namespace: biological_process alt_id: GO:0031575 alt_id: GO:0071780 def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] synonym: "mitotic checkpoint" RELATED [] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000075 ! cell cycle checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007094 name: mitotic spindle assembly checkpoint namespace: biological_process alt_id: GO:0044810 def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] synonym: "Dma1-dependent checkpoint" NARROW [] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT [] synonym: "SAC-independent checkpoint" NARROW [] is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0071173 ! spindle assembly checkpoint is_a: GO:0071174 ! mitotic spindle checkpoint intersection_of: GO:0071173 ! spindle assembly checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007095 name: mitotic G2 DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0031572 ! G2 DNA damage checkpoint is_a: GO:0044773 ! mitotic DNA damage checkpoint is_a: GO:0044818 ! mitotic G2/M transition checkpoint intersection_of: GO:0031572 ! G2 DNA damage checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007096 name: regulation of exit from mitosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010458 ! exit from mitosis relationship: regulates GO:0010458 ! exit from mitosis [Term] id: GO:0007097 name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] xref: MIPS_funcat:10.03.04.09 is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0007098 name: centrosome cycle namespace: biological_process alt_id: GO:0051297 def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] synonym: "centrosome organisation" EXACT [] synonym: "centrosome organization" EXACT [] synonym: "centrosome organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:10.03.05.01 is_a: GO:0022402 ! cell cycle process is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0007099 name: centriole replication namespace: biological_process alt_id: GO:0032054 def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124] synonym: "centriole duplication" EXACT [] synonym: "ciliary basal body duplication" RELATED [] synonym: "microtubule basal body duplication" BROAD [] is_a: GO:0022402 ! cell cycle process is_a: GO:0098534 ! centriole assembly relationship: part_of GO:0051298 ! centrosome duplication [Term] id: GO:0007100 name: mitotic centrosome separation namespace: biological_process def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] is_a: GO:0051299 ! centrosome separation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051299 ! centrosome separation intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0007101 name: obsolete male meiosis centrosome cycle namespace: biological_process def: "OBSOLETE. Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah] comment: false synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0007105 name: cytokinesis, site selection namespace: biological_process alt_id: GO:0010687 def: "The process of marking the place where cytokinesis will occur." [GOC:mtg_cell_cycle] synonym: "site selection involved in cell cycle cytokinesis" EXACT [] synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007106 name: obsolete cytokinesis, protein recruitment namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined. synonym: "cytokinesis, protein recruitment" EXACT [] is_obsolete: true [Term] id: GO:0007107 name: membrane addition at site of cytokinesis namespace: biological_process def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] synonym: "cytokinesis, membrane recruitment/generation" EXACT [] is_a: GO:0032506 ! cytokinetic process is_a: GO:0061024 ! membrane organization [Term] id: GO:0007108 name: obsolete cytokinesis, initiation of separation namespace: biological_process def: "OBSOLETE. The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. synonym: "cytokinesis, initiation of separation" EXACT [] synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0007109 name: obsolete cytokinesis, completion of separation namespace: biological_process def: "OBSOLETE. The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis, completion of separation" EXACT [] is_obsolete: true [Term] id: GO:0007110 name: meiosis I cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis I" EXACT [] is_a: GO:0033206 ! meiotic cytokinesis is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0007111 name: meiosis II cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis II" EXACT [] is_a: GO:0033206 ! meiotic cytokinesis is_a: GO:0061983 ! meiosis II cell cycle process [Term] id: GO:0007112 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033206 ! meiotic cytokinesis intersection_of: GO:0000910 ! cytokinesis intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007114 name: cell budding namespace: biological_process def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732] subset: goslim_candida subset: goslim_yeast synonym: "budding" BROAD [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0032505 ! reproduction of a single-celled organism is_a: GO:0051301 ! cell division [Term] id: GO:0007115 name: obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents two processes. synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0000282 consider: GO:0030010 [Term] id: GO:0007116 name: regulation of cell budding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] synonym: "regulation of budding" BROAD [] is_a: GO:0051302 ! regulation of cell division is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007114 ! cell budding relationship: regulates GO:0007114 ! cell budding [Term] id: GO:0007117 name: budding cell bud growth namespace: biological_process def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] synonym: "bud growth" BROAD [] xref: MIPS_funcat:42.29 is_a: GO:0022414 ! reproductive process is_a: GO:0040007 ! growth relationship: part_of GO:0007114 ! cell budding [Term] id: GO:0007118 name: budding cell apical bud growth namespace: biological_process def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] synonym: "apical bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007119 name: budding cell isotropic bud growth namespace: biological_process def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] synonym: "isotropic bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007120 name: axial cellular bud site selection namespace: biological_process def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] synonym: "axial bud site selection" EXACT [] synonym: "axial budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007121 name: bipolar cellular bud site selection namespace: biological_process def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] synonym: "bipolar bud site selection" EXACT [] synonym: "bipolar budding" BROAD [] synonym: "polar budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007122 name: obsolete loss of asymmetric budding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. synonym: "loss of asymmetric budding" EXACT [] is_obsolete: true consider: GO:0006033 [Term] id: GO:0007123 name: obsolete bud scar accumulation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. synonym: "bud scar accumulation" EXACT [] is_obsolete: true consider: GO:0000282 [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0016049 ! cell growth is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0007125 name: obsolete invasive growth namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it has been split into two new terms. synonym: "invasive growth" EXACT [] is_obsolete: true consider: GO:0001403 consider: GO:0044409 [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] synonym: "meiosis I nuclear division" EXACT [] xref: MIPS_funcat:10.03.02.01 xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0140013 ! meiotic nuclear division relationship: ends_during GO:0007134 ! meiotic telophase I [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007129 name: synapsis namespace: biological_process def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0007130 name: synaptonemal complex assembly namespace: biological_process def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732] synonym: "synaptonemal complex formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:0070193 ! synaptonemal complex organization relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0007131 name: reciprocal meiotic recombination namespace: biological_process alt_id: GO:0000021 alt_id: GO:0007145 def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] xref: MIPS_funcat:10.01.05.03.01 is_a: GO:0035825 ! homologous recombination is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007132 name: meiotic metaphase I namespace: biological_process def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: MIPS_funcat:10.03.02.03 xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007137 name: meiotic metaphase II namespace: biological_process def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007139 name: meiotic telophase II namespace: biological_process def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007140 name: male meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] synonym: "male meiosis" RELATED [] synonym: "male nuclear division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0048232 ! male gamete generation [Term] id: GO:0007141 name: male meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I is_a: GO:0007140 ! male meiotic nuclear division intersection_of: GO:0007127 ! meiosis I intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007140 ! male meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: part_of GO:0048232 ! male gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007144 name: female meiosis I namespace: biological_process def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I is_a: GO:0007143 ! female meiotic nuclear division intersection_of: GO:0007127 ! meiosis I intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007146 name: meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] is_a: GO:0000707 ! meiotic DNA recombinase assembly [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007143 ! female meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: part_of GO:0007292 ! female gamete generation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007149 name: obsolete colony morphology namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it describes a phenotype rather than a biological goal. synonym: "colony morphology" EXACT [] is_obsolete: true [Term] id: GO:0007150 name: obsolete growth pattern namespace: biological_process def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid] comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. synonym: "growth pattern" EXACT [] is_obsolete: true consider: GO:0040007 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: MIPS_funcat:34.07 xref: Wikipedia:Cell_adhesion is_a: GO:0022610 ! biological adhesion created_by: davidos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007156 name: homophilic cell adhesion via plasma membrane adhesion molecules namespace: biological_process def: "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0007157 name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules namespace: biological_process def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] synonym: "agglutination" RELATED [GOC:mah] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0007158 name: neuron cell-cell adhesion namespace: biological_process def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] synonym: "neuron adhesion" EXACT [] synonym: "neuronal cell adhesion" EXACT [] is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [] synonym: "leukocyte cell adhesion" EXACT [] is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0007160 name: cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] xref: MIPS_funcat:34.07.02 is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0007161 name: calcium-independent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007155 ! cell adhesion relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007164 name: establishment of tissue polarity namespace: biological_process def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: MIPS_funcat:30 xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0023052 ! signaling relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] subset: goslim_drosophila synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] xref: MIPS_funcat:30.05 is_a: GO:0007165 ! signal transduction [Term] id: GO:0007167 name: enzyme linked receptor protein signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01 is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007168 name: receptor guanylyl cyclase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030] synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007169 name: transmembrane receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.12 is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007170 name: obsolete transmembrane receptor protein tyrosine kinase ligand binding namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "transmembrane receptor protein tyrosine kinase ligand binding" EXACT [] is_obsolete: true consider: GO:0030971 [Term] id: GO:0007171 name: activation of transmembrane receptor protein tyrosine kinase activity namespace: biological_process def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007172 name: signal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862] synonym: "signal complex formation" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0007173 name: epidermal growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] synonym: "EGF receptor signaling pathway" EXACT [] synonym: "EGF receptor signalling pathway" EXACT [] synonym: "EGFR signaling pathway" EXACT [] synonym: "epidermal growth factor receptor signalling pathway" EXACT [] synonym: "ERBB1 signaling pathway" EXACT [PR:000006933] synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT [PR:000006933] xref: MIPS_funcat:30.05.01.12.01 is_a: GO:0038127 ! ERBB signaling pathway [Term] id: GO:0007174 name: epidermal growth factor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587] comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'. synonym: "EGF breakdown" EXACT [GOC:bf] synonym: "EGF catabolism" EXACT [GOC:bf] synonym: "EGF receptor ligand processing" RELATED [GOC:bf] synonym: "epidermal growth factor breakdown" EXACT [GOC:bf] synonym: "epidermal growth factor catabolism" EXACT [GOC:bf] synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf] synonym: "intracellular EGF processing" RELATED [PMID:2985587] synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723] is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007175 name: negative regulation of epidermal growth factor-activated receptor activity namespace: biological_process alt_id: GO:0007177 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] synonym: "EGF receptor downregulation" EXACT [] synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] synonym: "negative regulation of EGF receptor activity" EXACT [] synonym: "negative regulation of EGFR activity" EXACT [] synonym: "negative regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity relationship: negatively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity [Term] id: GO:0007176 name: regulation of epidermal growth factor-activated receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity." [GOC:dph, GOC:go_curators] synonym: "regulation of EGF receptor activity" EXACT [] synonym: "regulation of EGFR activity" EXACT [] synonym: "regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005006 ! epidermal growth factor-activated receptor activity relationship: regulates GO:0005006 ! epidermal growth factor-activated receptor activity [Term] id: GO:0007178 name: transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.18 is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007179 name: transforming growth factor beta receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "TGF-beta receptor signaling pathway" EXACT [] synonym: "TGF-beta receptor signalling pathway" EXACT [] synonym: "TGFbeta receptor signaling pathway" EXACT [] synonym: "TGFbeta receptor signalling pathway" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.18.01 is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: part_of GO:0071560 ! cellular response to transforming growth factor beta stimulus [Term] id: GO:0007180 name: obsolete transforming growth factor beta ligand binding to type II receptor namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type II receptor" EXACT [] synonym: "TGFbeta ligand binding to type II receptor" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" EXACT [] is_obsolete: true consider: GO:0005026 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0007181 name: transforming growth factor beta receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:R-HSA-170840, Wikipedia:TGF_beta_signaling_pathway] synonym: "TGF-beta receptor complex assembly" EXACT [] synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] synonym: "TGFbeta receptor complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0007182 name: common-partner SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782] synonym: "co-SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "common mediator SMAD protein phosphorylation" EXACT [] synonym: "common partner SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "common-mediator SMAD protein phosphorylation" EXACT [GOC:rl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007183 name: SMAD protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007185 name: transmembrane receptor protein tyrosine phosphatase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0038042 def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] subset: goslim_drosophila synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] synonym: "G-protein coupled receptor signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR signaling pathway" EXACT [] synonym: "GPCR signalling pathway" EXACT [] xref: MIPS_funcat:30.01.05.05 xref: MIPS_funcat:30.05.02.24 is_a: GO:0007165 ! signal transduction [Term] id: GO:0007187 name: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cyclic nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via cyclic nucleotide second messenger" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: has_part GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0007188 name: adenylate cyclase-modulating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578. synonym: "adenylate cyclase-modulating GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cAMP nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via cAMP second messenger" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via modulation of adenylate cyclase activity" EXACT [GOC:signaling] is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger relationship: has_part GO:0019933 ! cAMP-mediated signaling relationship: has_part GO:0043949 ! regulation of cAMP-mediated signaling relationship: has_part GO:0045761 ! regulation of adenylate cyclase activity [Term] id: GO:0007189 name: adenylate cyclase-activating G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0010579 alt_id: GO:0010580 def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway. synonym: "activation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:bf] synonym: "activation of adenylate cyclase activity involved in G-protein signaling" RELATED [GOC:signaling] synonym: "adenylate cyclase-activating GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "GPCR signaling pathway via activation of adenylate cyclase" EXACT [GOC:bf] synonym: "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT [GOC:signaling] synonym: "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED [GOC:mah] synonym: "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway is_a: GO:0019933 ! cAMP-mediated signaling intersection_of: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway intersection_of: has_part GO:0007190 ! activation of adenylate cyclase activity relationship: has_part GO:0007190 ! activation of adenylate cyclase activity [Term] id: GO:0007190 name: activation of adenylate cyclase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] synonym: "adenylate cyclase activator" RELATED [] synonym: "adenylyl cyclase activation" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0007191 name: adenylate cyclase-activating dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling] synonym: "activation of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" RELATED [GOC:mah] synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007192 name: adenylate cyclase-activating serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007193 name: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition. synonym: "adenylate cyclase-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "GPCR signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway relationship: has_part GO:0007194 ! negative regulation of adenylate cyclase activity relationship: has_part GO:0043951 ! negative regulation of cAMP-mediated signaling [Term] id: GO:0007194 name: negative regulation of adenylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase inhibitor" RELATED [] synonym: "down regulation of adenylate cyclase activity" EXACT [] synonym: "down-regulation of adenylate cyclase activity" EXACT [] synonym: "downregulation of adenylate cyclase activity" EXACT [] synonym: "inhibition of adenylate cyclase activity" NARROW [] synonym: "negative regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004016 ! adenylate cyclase activity relationship: negatively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0007195 name: adenylate cyclase-inhibiting dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007196 name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0007197 name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" RELATED [GOC:mah] synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0007198 name: adenylate cyclase-inhibiting serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" RELATED [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway [Term] id: GO:0007199 name: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cGMP nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via activation of guanylate cyclase activity" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via cGMP second messenger" EXACT [GOC:signaling] synonym: "guanylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling] is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger relationship: has_part GO:0019934 ! cGMP-mediated signaling relationship: has_part GO:0031284 ! positive regulation of guanylate cyclase activity [Term] id: GO:0007200 name: phospholipase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity. synonym: "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:signaling] synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:signaling] synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:dph, GOC:tb] synonym: "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] synonym: "PLC-activating GPCR signaling pathway" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: has_part GO:0007202 ! activation of phospholipase C activity relationship: has_part GO:0048016 ! inositol phosphate-mediated signaling [Term] id: GO:0007201 name: obsolete G-protein dissociation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. synonym: "G-protein dissociation" EXACT [] is_obsolete: true [Term] id: GO:0007202 name: activation of phospholipase C activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010863 ! positive regulation of phospholipase C activity [Term] id: GO:0007203 name: obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction, not a process. synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" EXACT [] is_obsolete: true consider: GO:0004435 [Term] id: GO:0007204 name: positive regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] synonym: "cytosolic calcium ion concentration elevation" EXACT [] synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] synonym: "elevation of calcium ion concentration in cytosol" EXACT [] synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] synonym: "elevation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0007205 name: protein kinase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" RELATED [GOC:mah] synonym: "protein kinase C-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: has_part GO:1990051 ! activation of protein kinase C activity [Term] id: GO:0007206 name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway" RELATED [GOC:bf] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" RELATED [GOC:mah] synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "phospholipase C-activating G-protein coupled glutamate receptor signaling pathway" RELATED [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0007207 name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "muscarinic receptor signaling pathway via activation of PLC" EXACT [GOC:signaling] synonym: "phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway" EXACT [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0007208 name: phospholipase C-activating serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway [Term] id: GO:0007209 name: phospholipase C-activating tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by tachykinin receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" RELATED [GOC:mah] synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0007210 name: serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "serotonin receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.24.01 is_a: GO:1903831 ! signal transduction involved in cellular response to ammonium ion relationship: part_of GO:1903351 ! cellular response to dopamine [Term] id: GO:0007211 name: octopamine or tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah] synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007212 name: dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah, PMID:21711983] synonym: "dopamine receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.24.03 is_a: GO:1903831 ! signal transduction involved in cellular response to ammonium ion relationship: has_part GO:0001963 ! synaptic transmission, dopaminergic relationship: part_of GO:1903351 ! cellular response to dopamine [Term] id: GO:0007213 name: G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] xref: MIPS_funcat:30.05.02.24.02 is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0095500 ! acetylcholine receptor signaling pathway [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.24.04 is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007215 name: glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "glutamate signaling pathway" EXACT [GOC:bf] synonym: "glutamate signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.24.05 is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007216 name: G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007215 ! glutamate receptor signaling pathway [Term] id: GO:0007217 name: tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] synonym: "tachykinin signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.24.06 is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007219 name: Notch signaling pathway namespace: biological_process alt_id: GO:0030179 def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] synonym: "N signaling pathway" EXACT [] synonym: "N signalling pathway" EXACT [] synonym: "Notch receptor signaling pathway" EXACT [] synonym: "Notch receptor signalling pathway" EXACT [] synonym: "Notch signalling pathway" EXACT [] synonym: "Notch-receptor signaling pathway" EXACT [] synonym: "Notch-receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.14 xref: Wikipedia:Notch_signaling_pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007220 name: Notch receptor processing namespace: biological_process def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] synonym: "N receptor processing" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0007221 name: positive regulation of transcription of Notch receptor target namespace: biological_process def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] synonym: "N receptor target transcription factor activation" RELATED [] synonym: "Notch receptor target transcription factor activation" RELATED [] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: part_of GO:0007219 ! Notch signaling pathway [Term] id: GO:0007223 name: Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled-2 signaling pathway" NARROW [] synonym: "frizzled-2 signalling pathway" NARROW [] synonym: "non-canonical Wnt signaling pathway" RELATED [] synonym: "Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] is_a: GO:0035567 ! non-canonical Wnt signaling pathway [Term] id: GO:0007224 name: smoothened signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] synonym: "hedgehog signaling pathway" EXACT [] synonym: "hh signaling pathway" NARROW [] synonym: "hh signalling pathway" NARROW [] synonym: "Shh signaling pathway" RELATED [GOC:dph] synonym: "smoothened signalling pathway" EXACT [] synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph] xref: MIPS_funcat:30.05.02.16 xref: Wikipedia:Hedgehog_signaling_pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007225 name: patched ligand maturation namespace: biological_process def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936] synonym: "Hedgehog protein processing" NARROW [] synonym: "hh protein processing" EXACT [] synonym: "patched ligand processing" RELATED [] is_a: GO:0035638 ! signal maturation is_a: GO:0051604 ! protein maturation relationship: part_of GO:0045880 ! positive regulation of smoothened signaling pathway [Term] id: GO:0007227 name: signal transduction downstream of smoothened namespace: biological_process def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] is_a: GO:0035556 ! intracellular signal transduction relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0007228 name: positive regulation of hh target transcription factor activity namespace: biological_process def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd] is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity relationship: part_of GO:0007227 ! signal transduction downstream of smoothened [Term] id: GO:0007229 name: integrin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "integrin-mediated signalling pathway" EXACT [] xref: MIPS_funcat:30.05.02.26 is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007230 name: obsolete calcium-o-sensing receptor pathway namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not make sense. synonym: "calcium-o-sensing receptor pathway" EXACT [] is_obsolete: true consider: GO:0019722 [Term] id: GO:0007231 name: osmosensory signaling pathway namespace: biological_process def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] synonym: "osmolarity sensing" EXACT [] synonym: "osmolarity sensing signaling pathway" EXACT [] synonym: "osmolarity sensing signalling pathway" EXACT [] synonym: "osmosensory signal transduction" EXACT [GOC:signaling] synonym: "osmosensory signalling pathway" EXACT [] synonym: "signal transduction during osmotic stress" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0007232 name: osmosensory signaling pathway via Sho1 osmosensor namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007234 name: osmosensory signaling via phosphorelay pathway namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system." [PMID:9843501] synonym: "osmolarity sensing via two-component system" EXACT [] synonym: "osmolarity signaling pathway via two-component system" EXACT [] synonym: "osmolarity signalling pathway via two-component system" EXACT [] synonym: "osmosensory signaling pathway via two-component system" NARROW [] synonym: "osmosensory signalling pathway via two-component system" EXACT [] synonym: "signal transduction during osmotic stress via two-component system" EXACT [] is_a: GO:0000160 ! phosphorelay signal transduction system is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007235 name: obsolete activation of Ypd1 protein namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ypd1 protein" EXACT [] is_obsolete: true [Term] id: GO:0007236 name: obsolete activation of Ssk1 protein namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ssk1 protein" EXACT [] is_obsolete: true [Term] id: GO:0007237 name: obsolete activation of Ssk2/Ssk22 proteins namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ssk2/Ssk22 proteins" EXACT [] is_obsolete: true [Term] id: GO:0007238 name: obsolete activation of Pbs2 namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Pbs2" EXACT [] is_obsolete: true [Term] id: GO:0007239 name: obsolete activation of Hog1 namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007240 name: obsolete nuclear translocation of Hog1 namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "nuclear translocation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007241 name: obsolete inactivation of Hog1 namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "inactivation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007244 name: obsolete MAPKKK cascade (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007245 name: obsolete activation of MAPKKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007246 name: obsolete activation of MAPKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007247 name: obsolete activation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0000750 [Term] id: GO:0007248 name: obsolete nuclear translocation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007249 name: I-kappaB kinase/NF-kappaB signaling namespace: biological_process def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560] synonym: "activation of the inhibitor of kappa kinase" RELATED [] synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf] synonym: "I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling] synonym: "NF-kappaB cascade" BROAD [] synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232] xref: MIPS_funcat:30.01.05.01.04 is_a: GO:0035556 ! intracellular signal transduction relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity [Term] id: GO:0007250 name: activation of NF-kappaB-inducing kinase activity namespace: biological_process def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] synonym: "activation of NIK activity" EXACT [GOC:bf] synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:1901224 ! positive regulation of NIK/NF-kappaB signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling relationship: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity [Term] id: GO:0007251 name: obsolete activation of the inhibitor of kappa kinase namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its meaning was unclear. synonym: "activation of the inhibitor of kappa kinase" EXACT [] is_obsolete: true consider: GO:0007249 [Term] id: GO:0007252 name: I-kappaB phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468] synonym: "IkappaB phosphorylation" EXACT [GOC:bf] synonym: "IKB phosphorylation" EXACT [GOC:bf] synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf] synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling [Term] id: GO:0007253 name: cytoplasmic sequestering of NF-kappaB namespace: biological_process def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic NF-kappaB retention" EXACT [] synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] synonym: "cytoplasmic NF-kappaB storage" EXACT [] synonym: "cytoplasmic retention of NF-kappaB" EXACT [] synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] synonym: "cytoplasmic storage of NF-kappaB" EXACT [] synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] is_a: GO:0032088 ! negative regulation of NF-kappaB transcription factor activity is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor [Term] id: GO:0007254 name: JNK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974] synonym: "JNK1 cascade" NARROW [GOC:add] synonym: "JNK2 cascade" NARROW [GOC:add] synonym: "JNK3 cascade" NARROW [GOC:add] synonym: "MAPK10 cascade" NARROW [GOC:add] synonym: "MAPK8 cascade" NARROW [GOC:add] synonym: "MAPK9 cascade" NARROW [GOC:add] synonym: "SAPK cascade" BROAD [] synonym: "stress-activated protein kinase cascade" BROAD [] xref: MIPS_funcat:30.01.05.01.02 is_a: GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0007256 name: activation of JNKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "activation of JUN kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKK activity" BROAD [] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade relationship: positively_regulates GO:0008545 ! JUN kinase kinase activity [Term] id: GO:0007257 name: activation of JUN kinase activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf] synonym: "activation of SAPK activity" BROAD [] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007258 name: JUN phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007259 name: receptor signaling pathway via JAK-STAT namespace: biological_process def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] synonym: "JAK-STAT cascade" NARROW [] synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling] xref: MIPS_funcat:30.01.05.01.01 xref: Wikipedia:JAK-STAT_signaling_pathway is_a: GO:0097696 ! receptor signaling pathway via STAT [Term] id: GO:0007260 name: tyrosine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0042502 alt_id: GO:0042503 alt_id: GO:0042504 alt_id: GO:0042505 alt_id: GO:0042506 alt_id: GO:0042507 alt_id: GO:0042508 def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] synonym: "tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: part_of GO:0007259 ! receptor signaling pathway via JAK-STAT [Term] id: GO:0007261 name: obsolete JAK-induced STAT protein dimerization namespace: biological_process def: "OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms. synonym: "JAK-induced STAT protein dimerization" EXACT [] is_obsolete: true consider: GO:0007260 consider: GO:0046983 [Term] id: GO:0007263 name: nitric oxide mediated signal transduction namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190] synonym: "nitric oxide signaling" EXACT [GOC:bf] synonym: "nitric oxide-mediated signal transduction" EXACT [] synonym: "NO mediated signal transduction" EXACT [] synonym: "NO-mediated signal transduction" EXACT [] xref: MIPS_funcat:30.01.09.01 is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0007264 name: small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] synonym: "small GTPase-mediated signal transduction" EXACT [] xref: MIPS_funcat:30.01.05.05.01 is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007265 name: Ras protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Ras mediated signal transduction" EXACT [] is_a: GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0007266 name: Rho protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rho mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: chemical synaptic transmission namespace: biological_process def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] subset: goslim_synapse synonym: "neurotransmission" RELATED [GOC:dph] synonym: "signal transmission across a synapse" BROAD [] synonym: "synaptic transmission" BROAD [] xref: MIPS_funcat:34.03.01 xref: Wikipedia:Neurotransmission is_a: GO:0098916 ! anterograde trans-synaptic signaling [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process alt_id: GO:0010554 def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph] comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. subset: goslim_synapse synonym: "neurotransmitter release" EXACT [] synonym: "neurotransmitter secretory pathway" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0099643 ! signal release from synapse relationship: occurs_in GO:0098793 ! presynapse relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007270 name: neuron-neuron synaptic transmission namespace: biological_process def: "The process of synaptic transmission from a neuron to another neuron across a synapse." [GOC:add, GOC:dos, GOC:jl, MeSH:D009435] synonym: "nerve-nerve synaptic transmission" RELATED [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007273 name: obsolete regulation of synapse namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string made no sense. synonym: "regulation of synapse" EXACT [] is_obsolete: true consider: GO:0007268 [Term] id: GO:0007274 name: neuromuscular synaptic transmission namespace: biological_process def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant xref: MIPS_funcat:41 is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] xref: MIPS_funcat:41.05.25 is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007277 name: pole cell development namespace: biological_process def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007278 name: pole cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007279 name: pole cell formation namespace: biological_process def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007280 name: pole cell migration namespace: biological_process def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0008354 ! germ cell migration [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] xref: MIPS_funcat:43.03.02 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007282 name: cystoblast division namespace: biological_process def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446] synonym: "cystoblast cell division" EXACT [] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. synonym: "spermatogonium division" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007285 name: primary spermatocyte growth namespace: biological_process def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007287 name: Nebenkern assembly namespace: biological_process def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238] comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. synonym: "nebenkern assembly" EXACT [PMID:9550716] synonym: "Nebenkern formation" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007005 ! mitochondrion organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0035082 ! axoneme assembly relationship: part_of GO:0007286 ! spermatid development relationship: part_of GO:0030317 ! flagellated sperm motility [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007290 name: spermatid nucleus elongation namespace: biological_process def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "spermatid nuclear elongation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0007291 name: sperm individualization namespace: biological_process def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007294 name: germarium-derived oocyte fate determination namespace: biological_process alt_id: GO:0016350 def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maintenance of oocyte identity" RELATED [] synonym: "oocyte cell fate determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030716 ! oocyte fate determination relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation [Term] id: GO:0007295 name: growth of a germarium-derived egg chamber namespace: biological_process def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "egg chamber growth" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007296 name: vitellogenesis namespace: biological_process def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] synonym: "yolk formation" EXACT [] synonym: "yolk production" EXACT systematic_synonym [] xref: Wikipedia:Vitellogenesis is_a: GO:0007028 ! cytoplasm organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007297 name: ovarian follicle cell migration namespace: biological_process def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "follicle cell migration" BROAD [] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007298 name: border follicle cell migration namespace: biological_process def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "border cell migration" BROAD [] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0007299 name: ovarian follicle cell-cell adhesion namespace: biological_process def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] synonym: "follicle cell adhesion" BROAD [] synonym: "ovarian follicle cell adhesion" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0090136 ! epithelial cell-cell adhesion relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007300 name: ovarian nurse cell to oocyte transport namespace: biological_process def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "nurse cell to oocyte transport" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007301 name: female germline ring canal formation namespace: biological_process def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] synonym: "nurse cell ring canal formation" NARROW [] synonym: "ovarian ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007302 name: nurse cell nucleus anchoring namespace: biological_process def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] is_a: GO:0051647 ! nucleus localization [Term] id: GO:0007303 name: cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] is_a: GO:0016482 ! cytosolic transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007304 name: chorion-containing eggshell formation namespace: biological_process def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "eggshell formation" BROAD [] is_a: GO:0030703 ! eggshell formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007305 name: vitelline membrane formation involved in chorion-containing eggshell formation namespace: biological_process def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb] is_a: GO:0030704 ! vitelline membrane formation intersection_of: GO:0030704 ! vitelline membrane formation intersection_of: part_of GO:0007304 ! chorion-containing eggshell formation relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007306 name: eggshell chorion assembly namespace: biological_process def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb] synonym: "insect chorion formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045229 ! external encapsulating structure organization relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007307 name: eggshell chorion gene amplification namespace: biological_process def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] is_a: GO:0006277 ! DNA amplification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0007308 name: oocyte construction namespace: biological_process alt_id: GO:0048110 def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0007309 name: oocyte axis specification namespace: biological_process alt_id: GO:0048111 def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte axis determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0007310 name: oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008072 alt_id: GO:0048123 def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007311 name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded namespace: biological_process alt_id: GO:0048124 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007312 name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008102 alt_id: GO:0030722 alt_id: GO:0048126 alt_id: GO:0048128 def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD [] synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" RELATED [GOC:mah] synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" RELATED [GOC:mah] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification" RELATED [] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" RELATED [GOC:mah] synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD [] synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD [] synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD [] synonym: "oocyte axis determination, establishment of position of nucleus" BROAD [] synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] synonym: "oocyte axis determination, positioning of nucleus" BROAD [] synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb] synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD [] is_a: GO:0007097 ! nuclear migration is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification intersection_of: GO:0007097 ! nuclear migration intersection_of: part_of GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007313 name: maternal specification of dorsal/ventral axis, oocyte, soma encoded namespace: biological_process alt_id: GO:0048125 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007314 name: oocyte anterior/posterior axis specification namespace: biological_process alt_id: GO:0048112 def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo [Term] id: GO:0007315 name: pole plasm assembly namespace: biological_process alt_id: GO:0048113 def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] is_a: GO:0007028 ! cytoplasm organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0007316 name: pole plasm RNA localization namespace: biological_process alt_id: GO:0048116 def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] synonym: "oocyte pole plasm RNA localization" EXACT [] synonym: "pole plasm RNA localisation" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007317 name: regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1902875 ! regulation of embryonic pattern specification is_a: GO:1903429 ! regulation of cell maturation is_a: GO:1904580 ! regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045451 ! pole plasm oskar mRNA localization relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0007318 name: pole plasm protein localization namespace: biological_process alt_id: GO:0048115 def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] synonym: "oocyte pole plasm protein localization" EXACT [] synonym: "pole plasm protein localisation" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007319 name: negative regulation of oskar mRNA translation namespace: biological_process def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] synonym: "down regulation of oskar mRNA translation" EXACT [] synonym: "down-regulation of oskar mRNA translation" EXACT [] synonym: "downregulation of oskar mRNA translation" EXACT [] synonym: "inhibition of oskar mRNA translation" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0007320 name: insemination namespace: biological_process def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] xref: Wikipedia:Insemination is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007620 ! copulation [Term] id: GO:0007321 name: sperm displacement namespace: biological_process def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0007323 name: peptide pheromone maturation namespace: biological_process alt_id: GO:0007324 alt_id: GO:0007326 alt_id: GO:0046613 def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "pheromone processing" EXACT [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0007329 name: positive regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] is_a: GO:0009371 ! positive regulation of transcription by pheromones is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [Term] id: GO:0007336 name: obsolete bilateral process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. synonym: "bilateral process" EXACT [] is_obsolete: true [Term] id: GO:0007337 name: obsolete unilateral process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. synonym: "unilateral process" EXACT [] is_obsolete: true [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] xref: MIPS_funcat:41.05.01 is_a: GO:0009566 ! fertilization [Term] id: GO:0007339 name: binding of sperm to zona pellucida namespace: biological_process def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] synonym: "ZPG binding" RELATED [] is_a: GO:0035036 ! sperm-egg recognition [Term] id: GO:0007340 name: acrosome reaction namespace: biological_process def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida." [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029] comment: If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss. xref: Wikipedia:Acrosome_reaction is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007341 name: penetration of zona pellucida namespace: biological_process def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007342 name: fusion of sperm to egg plasma membrane involved in single fertilization namespace: biological_process def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "sperm-oocyte fusion" NARROW [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007344 name: pronuclear fusion namespace: biological_process def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] is_a: GO:0000741 ! karyogamy is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007345 name: obsolete embryogenesis and morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. synonym: "embryogenesis and morphogenesis" EXACT [] is_obsolete: true consider: GO:0009653 consider: GO:0009790 [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000278 ! mitotic cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007347 name: regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035185 ! preblastoderm mitotic cell cycle relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0007348 name: regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "syncytial blastoderm cell cycle modulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulator" RELATED [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0022402 ! cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0007349 name: cellularization namespace: biological_process alt_id: GO:0009796 def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation [Term] id: GO:0007351 name: tripartite regional subdivision namespace: biological_process def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007352 name: zygotic specification of dorsal/ventral axis namespace: biological_process def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah] synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph] synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007353 name: obsolete ventral/lateral system namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. synonym: "ventral/lateral system" EXACT [] is_obsolete: true consider: GO:0009880 [Term] id: GO:0007354 name: zygotic determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0007355 name: anterior region determination namespace: biological_process def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007356 name: thorax and anterior abdomen determination namespace: biological_process def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007357 name: obsolete positive regulation of central gap gene transcription namespace: biological_process def: "OBSOLETE. The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of central gap gene" BROAD [] synonym: "activation of central gap gene transcription" NARROW [] synonym: "stimulation of central gap gene transcription" NARROW [] synonym: "up regulation of central gap gene transcription" EXACT [] synonym: "up-regulation of central gap gene transcription" EXACT [] synonym: "upregulation of central gap gene transcription" EXACT [] is_obsolete: true [Term] id: GO:0007358 name: establishment of central gap gene boundaries namespace: biological_process def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007359 name: posterior abdomen determination namespace: biological_process def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: Note that this process is exemplified in insects by the actions of the knirps gene product. is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007360 name: obsolete positive regulation of posterior gap gene transcription namespace: biological_process def: "OBSOLETE. The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of posterior gap gene" BROAD [] synonym: "activation of posterior gap gene transcription" NARROW [] synonym: "knirps activation" NARROW [] synonym: "stimulation of posterior gap gene transcription" NARROW [] synonym: "up regulation of posterior gap gene transcription" EXACT [] synonym: "up-regulation of posterior gap gene transcription" EXACT [] synonym: "upregulation of posterior gap gene transcription" EXACT [] is_obsolete: true [Term] id: GO:0007361 name: establishment of posterior gap gene boundaries namespace: biological_process def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007362 name: terminal region determination namespace: biological_process def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007363 name: obsolete positive regulation of terminal gap gene transcription namespace: biological_process def: "OBSOLETE. The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of terminal gap gene" BROAD [] synonym: "activation of terminal gap gene transcription" NARROW [] synonym: "stimulation of terminal gap gene transcription" NARROW [] synonym: "up regulation of terminal gap gene transcription" EXACT [] synonym: "up-regulation of terminal gap gene transcription" EXACT [] synonym: "upregulation of terminal gap gene transcription" EXACT [] is_obsolete: true [Term] id: GO:0007364 name: establishment of terminal gap gene boundary namespace: biological_process def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007365 name: periodic partitioning namespace: biological_process def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] comment: Note that examples of periodic partitions are tagmata, segments or parasegments. is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007366 name: periodic partitioning by pair rule gene namespace: biological_process def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007367 name: segment polarity determination namespace: biological_process def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007368 name: determination of left/right symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] synonym: "determination of left/right asymmetry" EXACT [GOC:dph] is_a: GO:0009855 ! determination of bilateral symmetry [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] subset: goslim_drosophila xref: MIPS_funcat:41.05.09 xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis relationship: has_part GO:0001705 ! ectoderm formation relationship: has_part GO:0001706 ! endoderm formation relationship: has_part GO:0001707 ! mesoderm formation [Term] id: GO:0007370 name: ventral furrow formation namespace: biological_process def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:0879694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007371 name: ventral midline determination namespace: biological_process alt_id: GO:0007372 alt_id: GO:0007373 def: "The regionalization process in which the area where the ventral midline will form is specified." [GOC:bf, GOC:isa_complete, GOC:vk] synonym: "determination of anterior border of ventral midline" NARROW [] synonym: "determination of posterior border of ventral midline" NARROW [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007418 ! ventral midline development [Term] id: GO:0007374 name: posterior midgut invagination namespace: biological_process def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:0879694238] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007375 name: anterior midgut invagination namespace: biological_process def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:0879694238] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007376 name: cephalic furrow formation namespace: biological_process def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:0879694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007377 name: germ-band extension namespace: biological_process def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:0879694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007378 name: amnioserosa formation namespace: biological_process def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:0879694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007379 name: segment specification namespace: biological_process def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] xref: MIPS_funcat:41.05.19.11 is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0035282 ! segmentation [Term] id: GO:0007380 name: specification of segmental identity, head namespace: biological_process def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035287 ! head segmentation [Term] id: GO:0007381 name: specification of segmental identity, labial segment namespace: biological_process def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007382 name: specification of segmental identity, maxillary segment namespace: biological_process def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007383 name: specification of segmental identity, antennal segment namespace: biological_process def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0007384 name: specification of segmental identity, thorax namespace: biological_process def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007385 name: specification of segmental identity, abdomen namespace: biological_process def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007386 name: compartment pattern specification namespace: biological_process def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "compartment specification" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007387 name: anterior compartment pattern formation namespace: biological_process def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior compartment pattern specification" RELATED [GOC:dph] is_a: GO:0007386 ! compartment pattern specification [Term] id: GO:0007388 name: posterior compartment specification namespace: biological_process def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007386 ! compartment pattern specification [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] subset: goslim_drosophila synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] xref: MIPS_funcat:41.01.03 is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007390 name: germ-band shortening namespace: biological_process def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] synonym: "germ-band retraction" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007391 name: dorsal closure namespace: biological_process def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007392 name: initiation of dorsal closure namespace: biological_process def: "Events that occur at the start of dorsal closure." [GOC:bf] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007393 name: dorsal closure, leading edge cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] is_a: GO:0035028 ! leading edge cell fate determination intersection_of: GO:0035028 ! leading edge cell fate determination intersection_of: part_of GO:0007391 ! dorsal closure relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment [Term] id: GO:0007394 name: dorsal closure, elongation of leading edge cells namespace: biological_process def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0016476 ! regulation of embryonic cell shape is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0007395 name: dorsal closure, spreading of leading edge cells namespace: biological_process def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] is_a: GO:0016477 ! cell migration relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007396 name: suture of dorsal opening namespace: biological_process def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007397 name: obsolete histogenesis and organogenesis namespace: biological_process def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] comment: This term was made obsolete because more appropriate terms were created. synonym: "histogenesis and organogenesis" EXACT [] is_obsolete: true consider: GO:0009887 consider: GO:0009888 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] xref: MIPS_funcat:45.03.17 xref: MIPS_funcat:47.03.01 is_a: GO:0048731 ! system development [Term] id: GO:0007400 name: neuroblast fate determination namespace: biological_process alt_id: GO:0007408 alt_id: GO:0043347 alt_id: GO:0043348 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "neuroblast cell fate determination" EXACT [] synonym: "neuroblast identity determination" EXACT [] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0007401 name: obsolete pan-neural process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because its meaning is ambiguous. synonym: "pan-neural process" EXACT [] is_obsolete: true consider: GO:0007399 consider: GO:0050877 [Term] id: GO:0007402 name: ganglion mother cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0048867 ! stem cell fate determination [Term] id: GO:0007403 name: glial cell fate determination namespace: biological_process alt_id: GO:0043361 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process alt_id: GO:0043349 alt_id: GO:0043350 def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0061351 ! neural precursor cell proliferation is_a: GO:0072089 ! stem cell proliferation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007405 ! neuroblast proliferation relationship: negatively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process alt_id: GO:0043351 alt_id: GO:0043352 def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001775 ! cell activation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007409 name: axonogenesis namespace: biological_process alt_id: GO:0007410 def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). synonym: "axon growth" NARROW [] synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007411 name: axon guidance namespace: biological_process alt_id: GO:0008040 def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "axon chemotaxis" RELATED [] synonym: "axon growth cone guidance" NARROW [] synonym: "axon pathfinding" EXACT [GOC:mah] xref: Wikipedia:Axon_guidance is_a: GO:0097485 ! neuron projection guidance relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007412 name: axon target recognition namespace: biological_process def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] is_a: GO:0007154 ! cell communication relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007413 name: axonal fasciculation namespace: biological_process def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] synonym: "fasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition is_a: GO:0106030 ! neuron projection fasciculation relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007414 name: axonal defasciculation namespace: biological_process def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] synonym: "defasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007415 name: defasciculation of motor neuron axon namespace: biological_process def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] is_a: GO:0007414 ! axonal defasciculation [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] subset: goslim_synapse synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0022607 ! cellular component assembly is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: MIPS_funcat:47.03.01.01 xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007419 name: ventral cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] xref: MIPS_funcat:47.03.01.01.01 is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0060322 ! head development [Term] id: GO:0007421 name: stomatogastric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] xref: MIPS_funcat:47.03.01.02 is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! animal organ development [Term] id: GO:0007424 name: open tracheal system development namespace: biological_process def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. xref: MIPS_funcat:47.03.09.05 is_a: GO:0060541 ! respiratory system development [Term] id: GO:0007425 name: epithelial cell fate determination, open tracheal system namespace: biological_process alt_id: GO:0046846 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] synonym: "tracheal cell fate determination" BROAD [] synonym: "tracheal epithelial cell fate determination" EXACT [] synonym: "tracheal placode cell fate determination" RELATED [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007426 name: tracheal outgrowth, open tracheal system namespace: biological_process def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007427 name: epithelial cell migration, open tracheal system namespace: biological_process def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal cell migration" BROAD [] synonym: "tracheal epithelial cell migration" RELATED [] is_a: GO:0010631 ! epithelial cell migration relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007428 name: primary branching, open tracheal system namespace: biological_process def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "primary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007429 name: secondary branching, open tracheal system namespace: biological_process def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "secondary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007430 name: terminal branching, open tracheal system namespace: biological_process def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007431 name: salivary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] xref: MIPS_funcat:47.03.21.02 is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0007432 name: salivary gland boundary specification namespace: biological_process def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] synonym: "salivary gland determination" EXACT [] is_a: GO:0010160 ! formation of animal organ boundary relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007433 name: larval salivary gland boundary specification namespace: biological_process def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007434 name: adult salivary gland boundary specification namespace: biological_process def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification [Term] id: GO:0007435 name: salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007436 name: larval salivary gland morphogenesis namespace: biological_process def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007437 name: adult salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators] is_a: GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0007438 name: oenocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] is_a: GO:0048468 ! cell development relationship: part_of GO:0001742 ! oenocyte differentiation [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007441 name: anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0061525 ! hindgut development [Term] id: GO:0007443 name: Malpighian tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061333 ! renal tubule morphogenesis relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0007444 name: imaginal disc development namespace: biological_process def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development is_a: GO:0060429 ! epithelium development [Term] id: GO:0007445 name: determination of imaginal disc primordium namespace: biological_process def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007446 name: imaginal disc growth namespace: biological_process def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] is_a: GO:0035265 ! organ growth relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007447 name: imaginal disc pattern formation namespace: biological_process def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007448 name: anterior/posterior pattern specification, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007449 name: proximal/distal pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0007450 name: dorsal/ventral pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0007451 name: dorsal/ventral lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc [Term] id: GO:0007453 name: clypeo-labral disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] synonym: "clypeo-labral disc metamorphosis" EXACT [] synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0007454 name: labial disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] synonym: "labial disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035217 ! labial disc development [Term] id: GO:0007455 name: eye-antennal disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] synonym: "eye-antennal disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007458 name: progression of morphogenetic furrow involved in compound eye morphogenesis namespace: biological_process def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0007460 name: R8 cell fate commitment namespace: biological_process alt_id: GO:0007461 def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] synonym: "restriction of R8 fate" EXACT [] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0007462 name: R1/R6 cell fate commitment namespace: biological_process def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0007463 name: R2/R5 cell fate commitment namespace: biological_process def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0007464 name: R3/R4 cell fate commitment namespace: biological_process def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0007465 name: R7 cell fate commitment namespace: biological_process def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0007468 name: regulation of rhodopsin gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0007469 name: antennal development namespace: biological_process def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007470 name: prothoracic disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] synonym: "prothoracic disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035219 ! prothoracic disc development [Term] id: GO:0007471 name: obsolete prothoracic morphogenesis namespace: biological_process def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid] comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. synonym: "prothoracic morphogenesis" EXACT [] is_obsolete: true consider: GO:0007470 [Term] id: GO:0007472 name: wing disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] synonym: "wing disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007473 name: wing disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0007474 name: imaginal disc-derived wing vein specification namespace: biological_process def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] synonym: "wing vein specification" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0007475 name: apposition of dorsal and ventral imaginal disc-derived wing surfaces namespace: biological_process def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis [Term] id: GO:0007476 name: imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] synonym: "wing morphogenesis" EXACT [] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis [Term] id: GO:0007477 name: notum development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007478 name: leg disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] synonym: "leg disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0007479 name: leg disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0007480 name: imaginal disc-derived leg morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007478 ! leg disc morphogenesis [Term] id: GO:0007481 name: haltere disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] synonym: "haltere disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007482 name: haltere development namespace: biological_process def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] is_a: GO:0048737 ! imaginal disc-derived appendage development relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007483 name: genital disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] synonym: "genital disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007484 name: imaginal disc-derived genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "genital development" BROAD [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007485 name: imaginal disc-derived male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "male genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0007486 name: imaginal disc-derived female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "female genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development is_a: GO:0030540 ! female genitalia development [Term] id: GO:0007487 name: analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007488 name: histoblast morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] synonym: "histoblast metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007489 name: maintenance of imaginal histoblast diploidy namespace: biological_process def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007490 name: tergite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007491 name: sternite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007493 name: endodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. synonym: "endoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] is_a: GO:0048565 ! digestive tract development [Term] id: GO:0007495 name: visceral mesoderm-endoderm interaction involved in midgut development namespace: biological_process def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] synonym: "visceral mesoderm/endoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007496 name: anterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007497 name: posterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007499 name: ectoderm and mesoderm interaction namespace: biological_process def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] synonym: "ectoderm/mesoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007500 name: mesodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. synonym: "mesoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007501 name: mesodermal cell fate specification namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. synonym: "mesoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007502 name: digestive tract mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007498 ! mesoderm development relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007503 name: fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] is_a: GO:0048513 ! animal organ development is_a: GO:0060612 ! adipose tissue development [Term] id: GO:0007504 name: larval fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007505 name: adult fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0007498 ! mesoderm development is_a: GO:0048608 ! reproductive structure development is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: MIPS_funcat:47.03.03.01 xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0007508 name: larval heart development namespace: biological_process def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:0879694238] is_a: GO:0007507 ! heart development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007509 name: mesoderm migration involved in gastrulation namespace: biological_process def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] is_a: GO:0008078 ! mesodermal cell migration is_a: GO:0042074 ! cell migration involved in gastrulation is_a: GO:0090130 ! tissue migration relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0007510 name: cardioblast cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0007512 name: adult heart development namespace: biological_process def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] synonym: "adult cardiac development" RELATED [] is_a: GO:0007507 ! heart development [Term] id: GO:0007515 name: obsolete lymph gland development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid] comment: This term was made obsolete because it was wrongly defined. synonym: "lymph gland development" EXACT [] is_obsolete: true consider: GO:0048535 consider: GO:0048542 [Term] id: GO:0007516 name: hemocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0042386 ! hemocyte differentiation [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] xref: MIPS_funcat:45.03.12 is_a: GO:0048513 ! animal organ development is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007518 name: myoblast fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048625 ! myoblast fate commitment [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process alt_id: GO:0048637 def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] xref: MIPS_funcat:41.05.15 xref: MIPS_funcat:45.03.12.01 is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0007520 name: myoblast fusion namespace: biological_process def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0007521 name: muscle cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0007522 name: visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development [Term] id: GO:0007523 name: larval visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007524 name: adult visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development [Term] id: GO:0007525 name: somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007526 name: larval somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007527 name: adult somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] synonym: "neuromuscular junction organization" EXACT [] synonym: "neuromuscular junction stability" RELATED [GOC:pr] synonym: "NMJ stability" RELATED [GOC:pr] is_a: GO:0050808 ! synapse organization [Term] id: GO:0007529 name: establishment of synaptic specificity at neuromuscular junction namespace: biological_process def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007528 ! neuromuscular junction development [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007531 name: mating type determination namespace: biological_process def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] xref: MIPS_funcat:34.11.03.07 is_a: GO:0007530 ! sex determination is_a: GO:0045165 ! cell fate commitment [Term] id: GO:0007532 name: regulation of mating-type specific transcription, DNA-templated namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "mating-type specific transcriptional control" EXACT [] synonym: "regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0007531 ! mating type determination [Term] id: GO:0007533 name: mating type switching namespace: biological_process def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] synonym: "mating type switching and recombination" RELATED [] is_a: GO:0007531 ! mating type determination is_a: GO:0022413 ! reproductive process in single-celled organism [Term] id: GO:0007534 name: gene conversion at mating-type locus namespace: biological_process def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] is_a: GO:0006312 ! mitotic recombination is_a: GO:0022414 ! reproductive process is_a: GO:0035822 ! gene conversion relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007535 name: donor selection namespace: biological_process def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492] synonym: "donor preference" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007536 name: activation of recombination (HML) namespace: biological_process def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045911 ! positive regulation of DNA recombination [Term] id: GO:0007537 name: inactivation of recombination (HML) namespace: biological_process def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0007538 name: primary sex determination namespace: biological_process def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007539 name: primary sex determination, soma namespace: biological_process def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018993 ! somatic sex determination [Term] id: GO:0007540 name: sex determination, establishment of X:A ratio namespace: biological_process def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007541 name: sex determination, primary response to X:A ratio namespace: biological_process def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007542 name: primary sex determination, germ-line namespace: biological_process def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007543 name: sex determination, somatic-gonadal interaction namespace: biological_process def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] synonym: "sex determination, somatic/gonadal interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007542 ! primary sex determination, germ-line [Term] id: GO:0007545 name: processes downstream of sex determination signal namespace: biological_process def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007546 name: somatic processes downstream of sex determination signal namespace: biological_process def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal [Term] id: GO:0007547 name: germ-line processes downstream of sex determination signal namespace: biological_process def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: MIPS_funcat:41.05.23 xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007549 name: dosage compensation namespace: biological_process def: "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] xref: Wikipedia:Dosage_compensation is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0007550 name: obsolete establishment of dosage compensation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. synonym: "establishment of dosage compensation" EXACT [] is_obsolete: true consider: GO:0007549 [Term] id: GO:0007551 name: obsolete maintenance of dosage compensation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. synonym: "maintenance of dosage compensation" EXACT [] is_obsolete: true consider: GO:0007549 [Term] id: GO:0007552 name: metamorphosis namespace: biological_process alt_id: GO:0046698 alt_id: GO:0046699 def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] xref: Wikipedia:Metamorphosis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0007553 name: regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] synonym: "regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045455 ! ecdysteroid metabolic process relationship: regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0007554 name: regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "regulation of ecdysteroid anabolism" EXACT [] synonym: "regulation of ecdysteroid biosynthesis" EXACT [] synonym: "regulation of ecdysteroid formation" EXACT [] synonym: "regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045456 ! ecdysteroid biosynthetic process relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0007555 name: regulation of ecdysteroid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045457 ! ecdysteroid secretion relationship: regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0007556 name: regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006716 ! juvenile hormone metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development relationship: regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0007557 name: regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone anabolism" EXACT [] synonym: "regulation of juvenile hormone biosynthesis" EXACT [] synonym: "regulation of juvenile hormone formation" EXACT [] synonym: "regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006718 ! juvenile hormone biosynthetic process relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0007558 name: regulation of juvenile hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045443 ! juvenile hormone secretion relationship: regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0007559 name: obsolete histolysis namespace: biological_process def: "OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. xref: Wikipedia:Histolysis is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0007560 name: imaginal disc morphogenesis namespace: biological_process alt_id: GO:0007452 def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] synonym: "imaginal disc metamorphosis" EXACT [] is_a: GO:0048563 ! post-embryonic animal organ morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0007444 ! imaginal disc development relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0007561 name: imaginal disc eversion namespace: biological_process def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007562 name: eclosion namespace: biological_process def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] xref: Wikipedia:Pupa#Emergence is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007563 name: regulation of eclosion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007562 ! eclosion relationship: regulates GO:0007562 ! eclosion [Term] id: GO:0007564 name: regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "regulation of cuticle hardening" NARROW [] synonym: "regulation of cuticle tanning" EXACT [] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007593 ! chitin-based cuticle sclerotization relationship: regulates GO:0007593 ! chitin-based cuticle sclerotization [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] synonym: "blastocyst implantation" EXACT [] xref: MIPS_funcat:41.05.02 is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007275 ! multicellular organism development relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0007567 name: parturition namespace: biological_process def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732] synonym: "egg laying" NARROW [] synonym: "giving birth" EXACT [] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] subset: goslim_chembl subset: goslim_generic synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process [Term] id: GO:0007569 name: cell aging namespace: biological_process def: "An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators] synonym: "cell ageing" EXACT [] xref: MIPS_funcat:40.20 is_a: GO:0007568 ! aging is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0007570 name: obsolete age dependent accumulation of genetic damage namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent accumulation of genetic damage" EXACT [] is_obsolete: true consider: GO:0001301 [Term] id: GO:0007571 name: age-dependent general metabolic decline namespace: biological_process def: "A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807] synonym: "age-dependent decreased translational activity" NARROW [] synonym: "age-dependent increased protein content" NARROW [] synonym: "age-dependent yeast cell size increase" RELATED [] synonym: "nucleolar size increase" NARROW [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007568 ! aging [Term] id: GO:0007572 name: obsolete age dependent decreased translational activity namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent decreased translational activity" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007573 name: obsolete age dependent increased protein content namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent increased protein content" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007574 name: obsolete cell aging (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. synonym: "cell aging (sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0007575 name: obsolete nucleolar size increase namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. synonym: "nucleolar size increase" EXACT [] is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0007576 name: nucleolar fragmentation namespace: biological_process alt_id: GO:0046616 def: "The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578] synonym: "nucleolar size increase" RELATED [] is_a: GO:0007000 ! nucleolus organization relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0007577 name: obsolete autophagic death (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] comment: This term was made obsolete because a more correct term has been created. synonym: "autophagic death (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0048102 [Term] id: GO:0007578 name: obsolete aging dependent sterility (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. synonym: "aging dependent sterility (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0030466 [Term] id: GO:0007579 name: obsolete senescence factor accumulation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jh] comment: This term was made obsolete because it does not represent a process. synonym: "senescence factor accumulation" EXACT [] is_obsolete: true [Term] id: GO:0007580 name: extrachromosomal circular DNA accumulation involved in cell aging namespace: biological_process def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0007581 name: obsolete age-dependent yeast cell size increase namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age-dependent yeast cell size increase" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007583 name: obsolete killer activity namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. synonym: "killer activity" EXACT [] is_obsolete: true consider: GO:0042267 [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] xref: MIPS_funcat:36.07.01 is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: MIPS_funcat:36.03 xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: goslim_pir xref: MIPS_funcat:36.05 xref: Wikipedia:Excretion is_a: GO:0003008 ! system process [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007590 name: obsolete fat body metabolic process (sensu Insecta) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. synonym: "fat body metabolic process (sensu Insecta)" EXACT [] is_obsolete: true [Term] id: GO:0007591 name: molting cycle, chitin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0042303 ! molting cycle [Term] id: GO:0007592 name: obsolete protein-based cuticle development namespace: biological_process def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "protein-based cuticle anabolism" EXACT [] synonym: "protein-based cuticle biosynthetic process" EXACT [] synonym: "protein-based cuticle development" EXACT [] synonym: "protein-based cuticle formation" EXACT [] synonym: "protein-based cuticle synthesis" EXACT [] is_obsolete: true consider: GO:0040002 consider: GO:0040003 [Term] id: GO:0007593 name: chitin-based cuticle sclerotization namespace: biological_process alt_id: GO:0045452 def: "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu] synonym: "chitin-based cuticle tanning" RELATED [GOC:bf, GOC:dos, GOC:sart] synonym: "cuticle hardening" NARROW [] is_a: GO:0007591 ! molting cycle, chitin-based cuticle is_a: GO:0021700 ! developmental maturation is_a: GO:0022404 ! molting cycle process [Term] id: GO:0007594 name: puparial adhesion namespace: biological_process def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] synonym: "puparial glue" RELATED [] is_a: GO:0022609 ! multicellular organism adhesion to substrate relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0007595 name: lactation namespace: biological_process def: "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." [ISBN:0198506732] synonym: "milk secretion" EXACT [GOC:pr] xref: Wikipedia:Lactation is_a: GO:0007589 ! body fluid secretion relationship: has_part GO:0060156 ! milk ejection reflex relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732] synonym: "blood clotting" EXACT [] xref: MIPS_funcat:36.25.16.09 xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007597 name: blood coagulation, intrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007598 name: blood coagulation, extrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] subset: goslim_drosophila xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: MIPS_funcat:34.11.01.03 xref: MIPS_funcat:36.25.01.01 xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007602 name: phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] synonym: "opsin" RELATED [] synonym: "phototransduction, visible light, light adaptation" NARROW [] synonym: "phototrophin mediated phototransduction" NARROW [] xref: Wikipedia:Visual_phototransduction is_a: GO:0007165 ! signal transduction is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0007603 name: phototransduction, visible light namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721] synonym: "visual transduction" EXACT [PMID:10611962] is_a: GO:0007602 ! phototransduction is_a: GO:0009584 ! detection of visible light [Term] id: GO:0007604 name: phototransduction, UV namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] synonym: "phototransduction, ultraviolet light" EXACT [] synonym: "phototransduction, ultraviolet radiation" EXACT [] synonym: "phototransduction, UV light" EXACT [] synonym: "phototransduction, UV radiation" EXACT [] synonym: "UV-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction is_a: GO:0009589 ! detection of UV is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: MIPS_funcat:36.25.01.03 xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007607 name: obsolete taste perception namespace: biological_process def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. synonym: "taste perception" EXACT [] is_obsolete: true consider: GO:0050909 consider: GO:0050912 [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: MIPS_funcat:36.25.01.13 xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process alt_id: GO:0044708 def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0008150 ! biological_process disjoint_from: GO:0032502 ! developmental process created_by: janelomax creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] xref: MIPS_funcat:36.25.03.04.01 is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007614 name: short-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Short-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007615 name: anesthesia-resistant memory namespace: biological_process def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] is_a: GO:0007613 ! memory [Term] id: GO:0007616 name: long-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Long-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0007618 ! mating relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] is_a: GO:0044703 ! multi-organism reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007619 name: courtship behavior namespace: biological_process def: "The behavior of an organism for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] synonym: "courtship behaviour" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] is_a: GO:0007618 ! mating [Term] id: GO:0007621 name: negative regulation of female receptivity namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity" EXACT [] synonym: "down-regulation of female receptivity" EXACT [] synonym: "downregulation of female receptivity" EXACT [] synonym: "inhibition of female receptivity" NARROW [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0007622 name: rhythmic behavior namespace: biological_process def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] synonym: "rhythmic behavioral response to stimulus" EXACT [] synonym: "rhythmic behaviour" EXACT [] synonym: "rhythmic behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007623 name: circadian rhythm namespace: biological_process alt_id: GO:0050895 def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] subset: goslim_drosophila subset: goslim_plant synonym: "circadian process" EXACT [] synonym: "circadian response" RELATED [] synonym: "response to circadian rhythm" RELATED [] xref: Wikipedia:Circadian_rhythm is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007624 name: ultradian rhythm namespace: biological_process def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721] is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007625 name: grooming behavior namespace: biological_process def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] synonym: "grooming behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: goslim_drosophila synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007627 name: obsolete larval behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "larval behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0007628 name: adult walking behavior namespace: biological_process def: "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] synonym: "adult walking behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior is_a: GO:0090659 ! walking behavior [Term] id: GO:0007629 name: flight behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] synonym: "flight behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007630 name: jump response namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "drinking" NARROW [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] xref: MIPS_funcat:36.03 xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007633 name: pattern orientation namespace: biological_process def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535] synonym: "behavioral response to pattern orientation" EXACT [] synonym: "behavioural response to pattern orientation" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007634 name: optokinetic behavior namespace: biological_process def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr, http://www.mercksource.com] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0007636 name: chemosensory jump behavior namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid] synonym: "chemosensory jump behaviour" EXACT [] synonym: "jump response to chemical stimulus" EXACT [] is_a: GO:0007630 ! jump response is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0007637 name: proboscis extension reflex namespace: biological_process def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus." [FB:FBrf0044924, GOC:jid] synonym: "behavioral response to nutritional stimulus, proboscis extension" EXACT [] synonym: "proboscis extension in response to nutritional stimulus" EXACT [] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0051780 ! behavioral response to nutrient is_a: GO:0060004 ! reflex [Term] id: GO:0007638 name: mechanosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] synonym: "behavioral response to mechanical stimulus" EXACT [] synonym: "behavioural response to mechanical stimulus" EXACT [] synonym: "mechanosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0009612 ! response to mechanical stimulus [Term] id: GO:0007639 name: homeostasis of number of meristem cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0008001 name: obsolete fibrinogen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not describe an activity. synonym: "fibrinogen" EXACT [] is_obsolete: true replaced_by: GO:0005577 [Term] id: GO:0008002 name: obsolete lamina lucida namespace: cellular_component def: "OBSOLETE. The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] comment: This term was made obsolete because it is thought to be an experimental artefact. xref: Wikipedia:Lamina_lucida is_obsolete: true [Term] id: GO:0008004 name: obsolete lamina reticularis namespace: cellular_component def: "OBSOLETE. A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] comment: This term was obsoleted because as a layer of the basement membrane, the lamina reticularis is thought to be an artefact. See PMID:24137544 and PMID:8061357. is_obsolete: true replaced_by: GO:0005604 [Term] id: GO:0008008 name: obsolete membrane attack complex protein beta2 chain namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "membrane attack complex protein beta2 chain" EXACT [] is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, http://www.copewithcytokines.de/cope.cgi?key=Cytokines, PMID:12183377] comment: See also the molecular function terms 'cytokine activity ; GO:0005125' and 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl xref: MIPS_funcat:40.02.03.03 is_a: GO:0005125 ! cytokine activity is_a: GO:0042379 ! chemokine receptor binding relationship: part_of GO:0060326 ! cell chemotaxis [Term] id: GO:0008010 name: structural constituent of chitin-based larval cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of larval cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008011 name: structural constituent of pupal chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of pupal cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008012 name: structural constituent of adult chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of adult cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008013 name: beta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0008014 name: obsolete calcium-dependent cell adhesion molecule activity namespace: molecular_function alt_id: GO:0001538 def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "cadherin" NARROW [] synonym: "calcium-dependent cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0016021 consider: GO:0016339 [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] xref: MIPS_funcat:36.07.07 is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060047 ! heart contraction relationship: regulates GO:0060047 ! heart contraction [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0008018 name: obsolete structural protein of chorion (sensu Drosophila) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the function is covered by a parent term. synonym: "structural protein of chorion (sensu Drosophila)" EXACT [] is_obsolete: true replaced_by: GO:0005213 [Term] id: GO:0008019 name: obsolete macrophage receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its name is ambiguous, and it was never defined. synonym: "macrophage receptor activity" EXACT [] is_obsolete: true consider: GO:0005044 consider: GO:0038187 [Term] id: GO:0008020 name: G protein-coupled photoreceptor activity namespace: molecular_function alt_id: GO:0004975 def: "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] synonym: "G protein coupled photoreceptor activity" EXACT [] synonym: "G-protein coupled photoreceptor activity" EXACT [] synonym: "photoreceptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009584 ! detection of visible light [Term] id: GO:0008021 name: synaptic vesicle namespace: cellular_component def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290] comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. subset: goslim_synapse synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667] xref: NIF_Subcellular:sao1071221672 xref: Wikipedia:Synaptic_vesicle is_a: GO:0070382 ! exocytic vesicle relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0008022 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] subset: goslim_chembl synonym: "C-terminal binding" EXACT [] synonym: "C-terminal end binding" EXACT [GOC:sl] synonym: "carboxy-terminal binding" RELATED [GOC:jsg] synonym: "carboxy-terminus binding" RELATED [GOC:sl] synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] synonym: "carboxyl-terminus binding" RELATED [GOC:sl] synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] synonym: "COOH-terminal binding" NARROW [GOC:jsg] synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] is_a: GO:0005515 ! protein binding [Term] id: GO:0008023 name: transcription elongation factor complex namespace: cellular_component def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0008024 name: cyclin/CDK positive transcription elongation factor complex namespace: cellular_component def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "positive transcription elongation factor complex b" RELATED [] is_a: GO:0008023 ! transcription elongation factor complex is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex [Term] id: GO:0008025 name: obsolete diazepam binding inhibitor activity namespace: molecular_function def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732, PMID:11883709] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "DBI" EXACT [] synonym: "diazepam binding inhibitor activity" EXACT [] synonym: "diazepam-binding inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004857 consider: GO:0030156 consider: GO:0050796 consider: GO:0050809 consider: GO:0050810 consider: GO:0050811 consider: GO:0050812 [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0008505 def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" xref: Reactome:R-HSA-433698 "SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0008029 name: pentraxin receptor activity namespace: molecular_function def: "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). synonym: "pentaxin receptor" EXACT [] is_a: GO:0001847 ! opsonin receptor activity relationship: has_part GO:0001864 ! pentraxin binding [Term] id: GO:0008030 name: neuronal pentraxin receptor activity namespace: molecular_function def: "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:18840757] synonym: "neuronal pentaxin receptor" EXACT [] is_a: GO:0008029 ! pentraxin receptor activity [Term] id: GO:0008031 name: eclosion hormone activity namespace: molecular_function def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008033 name: tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] subset: goslim_yeast synonym: "tRNA maturation" EXACT [GOC:vw] xref: MIPS_funcat:11.04.02 is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0008034 name: obsolete lipoprotein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning. synonym: "lipoprotein binding" EXACT [] is_obsolete: true consider: GO:0071723 consider: GO:0071813 [Term] id: GO:0008035 name: high-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah] synonym: "HDL binding" EXACT [GOC:mah] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0008036 name: diuretic hormone receptor activity namespace: molecular_function def: "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0008037 name: cell recognition namespace: biological_process def: "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] subset: goslim_pir synonym: "recognition of surroundings by cell" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008038 name: neuron recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] synonym: "neuronal cell recognition" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0008039 name: synaptic target recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] subset: goslim_synapse synonym: "neuronal targeting" EXACT [] is_a: GO:0008038 ! neuron recognition [Term] id: GO:0008041 name: obsolete storage protein of fat body (sensu Insecta) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. synonym: "storage protein of fat body (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0008042 name: obsolete iron-sulfur electron transfer carrier namespace: molecular_function def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ferredoxin" NARROW [] synonym: "iron-sulfur electron transfer carrier" EXACT [] synonym: "iron-sulphur electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008043 name: intracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717] is_a: GO:0070288 ! ferritin complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0008044 name: obsolete adult behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "adult behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030534 [Term] id: GO:0008045 name: motor neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] synonym: "motoneuron axon guidance" EXACT [] synonym: "motor axon guidance" EXACT [] synonym: "motor axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0008046 name: axon guidance receptor activity namespace: molecular_function def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666] synonym: "receptor activity involved in axon guidance" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0004888 ! transmembrane signaling receptor activity intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0008047 name: enzyme activator activity namespace: molecular_function alt_id: GO:0010577 def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] synonym: "metalloenzyme activator activity" NARROW [] xref: MIPS_funcat:18.02.01.01 is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0043085 ! positive regulation of catalytic activity [Term] id: GO:0008048 name: calcium sensitive guanylate cyclase activator activity namespace: molecular_function def: "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah] is_a: GO:0030250 ! guanylate cyclase activator activity [Term] id: GO:0008049 name: male courtship behavior namespace: biological_process alt_id: GO:0016542 def: "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] synonym: "male courtship behaviour" EXACT [] is_a: GO:0007619 ! courtship behavior is_a: GO:0060179 ! male mating behavior [Term] id: GO:0008050 name: female courtship behavior namespace: biological_process def: "The behavior of a female, for the purpose of attracting a sexual partner." [GOC:bf, GOC:pr] synonym: "female courtship behaviour" EXACT [] is_a: GO:0007619 ! courtship behavior is_a: GO:0060180 ! female mating behavior [Term] id: GO:0008051 name: obsolete farnesyl-diphosphate farnesyl transferase complex namespace: cellular_component def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. synonym: "farnesyl-diphosphate farnesyl transferase complex" EXACT [] is_obsolete: true consider: GO:0004310 [Term] id: GO:0008052 name: sensory organ boundary specification namespace: biological_process def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "sense organ boundary specification" EXACT [GOC:dph] is_a: GO:0010160 ! formation of animal organ boundary relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048284 ! organelle fusion [Term] id: GO:0008055 name: ocellus pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment anabolism" EXACT [] synonym: "ocellus pigment biosynthesis" EXACT [] synonym: "ocellus pigment formation" EXACT [] synonym: "ocellus pigment synthesis" EXACT [] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0008056 name: ocellus development namespace: biological_process def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0008057 name: eye pigment granule organization namespace: biological_process alt_id: GO:0008059 alt_id: GO:0045318 alt_id: GO:0048751 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] synonym: "eye pigment granule organisation" EXACT [GOC:mah] synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008058 name: ocellus pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] synonym: "ocellus pigment granule organisation" EXACT [] synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila is_a: GO:0008144 ! drug binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0008062 name: eclosion rhythm namespace: biological_process def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0007562 ! eclosion [Term] id: GO:0008063 name: Toll signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] synonym: "Tl signaling pathway" EXACT [] synonym: "Tl signalling pathway" EXACT [] synonym: "Toll signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0008064 name: regulation of actin polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0030832 ! regulation of actin filament length is_a: GO:0110053 ! regulation of actin filament organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008154 ! actin polymerization or depolymerization relationship: regulates GO:0008154 ! actin polymerization or depolymerization [Term] id: GO:0008065 name: establishment of blood-nerve barrier namespace: biological_process def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] synonym: "establishment of blood/nerve barrier" EXACT [] is_a: GO:0001885 ! endothelial cell development relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0016595 ! glutamate binding [Term] id: GO:0008067 name: obsolete metabotropic glutamate, GABA-B-like receptor activity namespace: molecular_function alt_id: GO:0001643 alt_id: GO:0001645 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class C G protein coupled receptor" BROAD [] synonym: "class C G-protein coupled receptor" BROAD [] synonym: "class C GPCR" BROAD [] synonym: "class C orphan receptor activity" EXACT [] synonym: "metabotropic glutamate, GABA-B-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0008068 name: extracellularly glutamate-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. synonym: "extracellular-glutamate-gated chloride channel activity" EXACT [] is_a: GO:0005234 ! extracellularly glutamate-gated ion channel activity is_a: GO:0005254 ! chloride channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0008069 name: dorsal/ventral axis specification, ovarian follicular epithelium namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED [] synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009950 ! dorsal/ventral axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0008070 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008071 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD [] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008073 name: ornithine decarboxylase inhibitor activity namespace: molecular_function def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity relationship: negatively_regulates GO:0004586 ! ornithine decarboxylase activity [Term] id: GO:0008074 name: guanylate cyclase complex, soluble namespace: cellular_component def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0008075 name: obsolete receptor guanylate cyclase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] comment: This term was made obsolete because it represents a class of gene products. synonym: "receptor guanylate cyclase activity" EXACT [] is_obsolete: true consider: GO:0004383 consider: GO:0038023 [Term] id: GO:0008076 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: NIF_Subcellular:sao371494298 is_a: GO:0034705 ! potassium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008077 name: obsolete Hsp70/Hsp90 organizing protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:rb] comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] synonym: "Hsp70/Hsp90 organizing protein activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] synonym: "mesoderm cell migration" EXACT [] is_a: GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0008079 name: translation termination factor activity namespace: molecular_function def: "Functions in the termination of translation." [GOC:ma] is_a: GO:0008135 ! translation factor activity, RNA binding relationship: part_of GO:0006415 ! translational termination [Term] id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.5 xref: Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2" xref: Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2" xref: Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842" is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] subset: goslim_chembl synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 xref: Reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends" is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl xref: MIPS_funcat:40.02.03.05 is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0008084 name: imaginal disc growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah] synonym: "imaginal disc growth factor" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0008085 name: obsolete phototransduction, visible light, light adaptation namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous. synonym: "phototransduction, visible light, light adaptation" EXACT [] is_obsolete: true consider: GO:0007602 [Term] id: GO:0008086 name: light-activated voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport] synonym: "light-activated voltage gated calcium channel activity" EXACT [] synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity is_a: GO:0010461 ! light-activated ion channel activity relationship: part_of GO:0019722 ! calcium-mediated signaling [Term] id: GO:0008087 name: light-activated voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] synonym: "light-activated voltage gated calcium channel complex" EXACT [] synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0005891 ! voltage-gated calcium channel complex [Term] id: GO:0008088 name: axo-dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" NARROW [] synonym: "axonal transport" NARROW [] synonym: "axoplasmic transport" NARROW [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! transport along microtubule relationship: occurs_in GO:0043005 ! neuron projection [Term] id: GO:0008089 name: anterograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "anterograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport relationship: occurs_in GO:1904115 ! axon cytoplasm [Term] id: GO:0008090 name: retrograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport relationship: occurs_in GO:1904115 ! axon cytoplasm [Term] id: GO:0008091 name: spectrin namespace: cellular_component def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] xref: NIF_Subcellular:sao536287099 xref: Wikipedia:Spectrin is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008093 name: cytoskeletal adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0008094 name: DNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004011 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [GOC:jl] synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008096 name: juvenile hormone epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141] xref: EC:3.3.2 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0008097 name: 5S rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0008098 name: 5S rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] is_a: GO:0008097 ! 5S rRNA binding [Term] id: GO:0008100 name: obsolete lipophorin namespace: molecular_function def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "lipophorin" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0008103 name: oocyte microtubule cytoskeleton polarization namespace: biological_process alt_id: GO:0048129 def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007309 ! oocyte axis specification relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] xref: MIPS_funcat:18.01.03 is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008106 name: alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] synonym: "alcohol:NADP dehydrogenase activity" EXACT [] synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] synonym: "aldehyde reductase (NADPH2) activity" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] id: GO:0008107 name: galactoside 2-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] xref: EC:2.4.1.69 xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-9036987 "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec" xref: Reactome:R-HSA-9603982 "FUT2 transfers Fuc to LeA to form LeB" xref: Reactome:R-HSA-9603983 "FUT2 transfers Fuc to LeX to form LeY" xref: RHEA:24431 is_a: GO:0031127 ! alpha-(1,2)-fucosyltransferase activity [Term] id: GO:0008108 name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] synonym: "uridyltransferase activity" BROAD [EC:2.7.7.12] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] xref: EC:2.7.7.12 xref: KEGG_REACTION:R00955 xref: MetaCyc:GALACTURIDYLYLTRANS-RXN xref: Reactome:R-HSA-5610038 "Defective GALT does not transfer UMP to Gal1P" xref: Reactome:R-HSA-70361 "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal" xref: RHEA:13989 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008109 name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] xref: EC:2.4.1.150 xref: MetaCyc:2.4.1.150-RXN xref: RHEA:17413 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008110 name: L-histidine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16565] synonym: "histidine aminotransferase activity" BROAD [] synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38] synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] xref: EC:2.6.1.38 xref: KEGG_REACTION:R01161 xref: MetaCyc:HISTTRANSAM-RXN xref: RHEA:16565 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008111 name: alpha-methylacyl-CoA racemase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] xref: EC:5.1.99.4 xref: MetaCyc:5.1.99.4-RXN xref: Reactome:R-HSA-192056 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA" xref: Reactome:R-HSA-193452 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA" xref: Reactome:R-HSA-193736 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" xref: Reactome:R-HSA-193763 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" xref: Reactome:R-HSA-389897 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA" xref: RHEA:12657 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0008112 name: nicotinamide N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23884] synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] xref: EC:2.1.1.1 xref: KEGG_REACTION:R01269 xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-5359451 "NNMT transfers CH3 from SAM to NAM to form MNA" xref: RHEA:23884 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008113 name: peptide-methionine (S)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0033742 alt_id: GO:0072561 def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "MsrA" RELATED [EC:1.8.4.11] synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] synonym: "peptide-methionine-(S)-S-oxide reductase activity" EXACT [] synonym: "protein-methionine-S-oxide reductase activity" EXACT [] xref: EC:1.8.4.11 xref: MetaCyc:RXN-8668 xref: MetaCyc:RXN-8669 xref: Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides" xref: Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine" is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0008114 name: phosphogluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] xref: EC:1.1.1.43 xref: MetaCyc:1.1.1.43-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008115 name: sarcosine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2)." [EC:1.5.3.1, RHEA:13313] synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] xref: EC:1.5.3.1 xref: KEGG_REACTION:R00610 xref: MetaCyc:SARCOX-RXN xref: RHEA:13313 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0008116 name: prostaglandin-I synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23580] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] synonym: "cytochrome P450 CYP8A1" NARROW [] synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] xref: EC:5.3.99.4 xref: KEGG_REACTION:R02267 xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN xref: Reactome:R-HSA-76496 "PTGIS, CYP8A1 isomerise PGH2 to PGI2" xref: RHEA:23580 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0008117 name: sphinganine-1-phosphate aldolase activity namespace: molecular_function alt_id: GO:0016001 def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] xref: EC:4.1.2.27 xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN xref: Reactome:R-HSA-428676 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal" xref: Reactome:R-HSA-428681 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal" xref: RHEA:18593 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008118 name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "SiaT" RELATED [EC:2.4.99.6] xref: EC:2.4.99.6 xref: MetaCyc:2.4.99.6-RXN xref: RHEA:15572 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0008119 name: thiopurine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "TPMT" RELATED [EC:2.1.1.67] xref: EC:2.1.1.67 xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP" xref: Reactome:R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP" is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008120 name: ceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] xref: EC:2.4.1.80 xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1638104 "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide" xref: RHEA:12088 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008121 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] synonym: "coenzyme Q-cytochrome c oxidoreductase activity" EXACT [] synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 activity" EXACT [] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: MetaCyc:1.10.2.2-RXN is_a: GO:0009055 ! electron transfer activity is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0008123 name: cholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.14.23] synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.14.23] synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.14.23] synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.14.23] synonym: "cytochrome P450 CYP7A1" NARROW [] xref: EC:1.14.14.23 xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN xref: Reactome:R-HSA-192051 "CYP7A1 7-hydroxylates CHOL" xref: RHEA:21812 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008124 name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11920] synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4alpha-carbinolamine dehydratase activity" RELATED [] synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] xref: EC:4.2.1.96 xref: KEGG_REACTION:R04734 xref: MetaCyc:RXN-7908 xref: Reactome:R-HSA-71146 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O" xref: RHEA:11920 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008125 name: obsolete pancreatic elastase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] comment: This term was made obsolete because it represents a gene product. synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatic elastase I activity" EXACT [] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] xref: EC:3.4.21.36 xref: MetaCyc:3.4.21.36-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008126 name: acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] synonym: "chloroesterase" NARROW [EC:3.1.1.6] synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: MetaCyc:ACETYLESTERASE-RXN xref: UM-BBD_reactionID:r0170 is_a: GO:0034338 ! short-chain carboxylesterase activity [Term] id: GO:0008127 name: quercetin 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15381] synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] synonym: "quercetinase activity" EXACT [EC:1.13.11.24] xref: EC:1.13.11.24 xref: KEGG_REACTION:R02156 xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN xref: Reactome:R-HSA-8953398 "PIR oxygenates quercetin" xref: RHEA:15381 xref: UM-BBD_reactionID:r0891 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008129 name: obsolete actinidain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] comment: This term was made obsolete because it represents a gene product. synonym: "actinidain activity" EXACT [] synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] xref: EC:3.4.22.14 xref: MetaCyc:3.4.22.14-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008130 name: obsolete neutrophil collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "neutrophil collagenase activity" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] xref: EC:3.4.24.34 xref: MetaCyc:3.4.24.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008131 name: primary amine oxidase activity namespace: molecular_function alt_id: GO:0004041 alt_id: GO:0008122 def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4, MetaCyc:RXN-9597] synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase activity" BROAD [EC:1.4.3.21] synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21] xref: EC:1.4.3.21 xref: KEGG_REACTION:R01853 xref: MetaCyc:RXN-9597 xref: Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT" xref: Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA" xref: Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR" xref: Reactome:R-HSA-374909 "Metabolism of Noradrenaline" xref: Reactome:R-HSA-379382 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)" xref: Reactome:R-HSA-379395 "Oxidation of 3-Methoxytyramine to homovanillic acid" xref: Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT" xref: Reactome:R-HSA-5696146 "AOC2 deaminates TYR" xref: Reactome:R-HSA-5696183 "AOC3 deaminates BZAM" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0008132 name: obsolete pancreatic elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008133 name: obsolete collagenase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008135 name: translation factor activity, RNA binding namespace: molecular_function def: "Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding is_a: GO:0090079 ! translation regulator activity, nucleic acid binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0008137 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out)." [EC:7.1.1.2] synonym: "coenzyme Q reductase activity" EXACT [EC:7.1.1.2] synonym: "complex 1 dehydrogenase activity" RELATED [EC:7.1.1.2] synonym: "complex I (electron transport chain) activity" RELATED [EC:7.1.1.2] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:7.1.1.2] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:7.1.1.2] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:7.1.1.2] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:7.1.1.2] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:7.1.1.2] synonym: "electron transfer complex I activity" RELATED [EC:7.1.1.2] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:7.1.1.2] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:7.1.1.2] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-CoQ reductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:7.1.1.2] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:7.1.1.2] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:7.1.1.2] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:7.1.1.2] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:7.1.1.2] synonym: "type 1 dehydrogenase activity" RELATED [EC:7.1.1.2] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:7.1.1.2 xref: MetaCyc:NADH-DEHYDROG-A-RXN xref: MetaCyc:RXN0-5330 xref: Reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to QH2" xref: RHEA:29091 is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0008138 name: protein tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] comment: Note that this term applies only to free amino acids. Consider 'protein serine/threonine phosphatase activity' or 'protein tyrosine/serine/threonine phosphatase activity' if you want to annotate a protein phosphatase. See discussion at https://github.com/geneontology/go-ontology/issues/12183 synonym: "dual-specificity protein phosphatase" BROAD [] xref: Reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs" xref: Reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008139 name: nuclear localization sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] synonym: "NLS binding" EXACT [] synonym: "nuclear localisation sequence binding" EXACT [GOC:mah] synonym: "nuclear localization signal binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0008140 name: cAMP response element binding protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah] synonym: "3',5' cAMP response element binding protein binding" EXACT [] synonym: "3',5'-cAMP response element binding protein binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] synonym: "CBP" RELATED [GOC:bf] synonym: "CREB binding" EXACT [] synonym: "cyclic AMP response element binding protein binding" EXACT [] is_a: GO:0140297 ! DNA-binding transcription factor binding [Term] id: GO:0008141 name: obsolete puparial glue (sensu Diptera) namespace: molecular_function def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "puparial glue (sensu Diptera)" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0007594 [Term] id: GO:0008142 name: oxysterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [GOC:curators] is_a: GO:0032934 ! sterol binding [Term] id: GO:0008143 name: poly(A) binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] synonym: "poly(A) binding, within an RNA molecule" EXACT [] synonym: "poly(rA) binding" EXACT [GOC:mah] synonym: "poly-A binding" EXACT [GOC:mah] synonym: "polyadenylate binding" EXACT [GOC:mah] is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0008144 name: drug binding namespace: molecular_function def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0008145 name: phenylalkylamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl] is_a: GO:0008144 ! drug binding is_a: GO:0043176 ! amine binding [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] subset: goslim_chembl synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP" xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP" xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP" xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008147 name: structural constituent of bone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008148 name: obsolete negative transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "negative transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0032785 [Term] id: GO:0008149 name: obsolete para-aminobenzoic acid (PABA) synthase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. synonym: "para-aminobenzoic acid (PABA) synthase" EXACT [] is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process created_by: janelomax creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: MIPS_funcat:01 xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008153 name: para-aminobenzoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] synonym: "4-aminobenzoic acid biosynthesis" EXACT [] synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] synonym: "p-aminobenzoic acid biosynthesis" EXACT [] synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] synonym: "PABA biosynthesis" EXACT [] synonym: "PABA biosynthetic process" EXACT [] synonym: "para-aminobenzoic acid anabolism" EXACT [] synonym: "para-aminobenzoic acid biosynthesis" EXACT [] synonym: "para-aminobenzoic acid formation" EXACT [] synonym: "para-aminobenzoic acid synthesis" EXACT [] synonym: "vitamin Bx biosynthesis" EXACT [] synonym: "vitamin Bx biosynthetic process" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046482 ! para-aminobenzoic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0008154 name: actin polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0008155 name: obsolete larval behavior (sensu Drosophila) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. synonym: "larval behavior (sensu Drosophila)" EXACT [] is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0008156 name: negative regulation of DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] synonym: "DNA replication inhibitor" RELATED [] synonym: "down regulation of DNA replication" EXACT [] synonym: "down-regulation of DNA replication" EXACT [] synonym: "downregulation of DNA replication" EXACT [] synonym: "inhibition of DNA replication" NARROW [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006260 ! DNA replication relationship: negatively_regulates GO:0006260 ! DNA replication [Term] id: GO:0008157 name: protein phosphatase 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0008158 name: hedgehog receptor activity namespace: molecular_function def: "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137] synonym: "patched activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0097108 ! hedgehog family protein binding [Term] id: GO:0008159 name: obsolete positive transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "positive transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0032786 [Term] id: GO:0008160 name: protein tyrosine phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732] is_a: GO:0072542 ! protein phosphatase activator activity relationship: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0008161 name: obsolete carbamate resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "carbamate resistance" EXACT [] is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0008162 name: obsolete cyclodiene resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "cyclodiene resistance" EXACT [] is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0008163 name: obsolete DDT resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "DDT resistance" EXACT [] is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0008164 name: obsolete organophosphorus resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "organophosphorus resistance" EXACT [] is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0008165 name: obsolete pyrethroid resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "pyrethroid resistance" EXACT [] is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0008166 name: obsolete viral replication namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. synonym: "viral replication" EXACT [] is_obsolete: true consider: GO:0019079 [Term] id: GO:0008167 name: obsolete sigma virus replication namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] synonym: "sigma virus replication" EXACT [] is_obsolete: true replaced_by: GO:0019079 [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: Reactome:R-HSA-379387 "methylation of Dopamine to form 3-Methoxytyramine" xref: Reactome:R-HSA-379464 "Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid" xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII" xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0008169 name: C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008170 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008171 name: O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 xref: Reactome:R-HSA-5578717 "BCDIN3D dimethylates 5' phosphate of pre-miR-145" xref: Reactome:R-HSA-5629203 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH" xref: Reactome:R-HSA-5629218 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1" xref: Reactome:R-HSA-5629237 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH" xref: Reactome:R-HSA-6790907 "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008172 name: S-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 xref: Reactome:R-HSA-209821 "Methylation of N-acetyl-5-HT to form melatonin" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008173 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). xref: Reactome:R-HSA-191784 "snRNA Cap hypermethylation" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA relationship: part_of GO:0001510 ! RNA methylation [Term] id: GO:0008174 name: mRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity relationship: part_of GO:0080009 ! mRNA methylation [Term] id: GO:0008175 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] xref: Reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)" xref: Reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)" xref: Reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)" xref: Reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)" xref: Reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34" xref: Reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine" is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0030488 ! tRNA methylation [Term] id: GO:0008176 name: tRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity relationship: part_of GO:0106004 ! tRNA (guanine-N7)-methylation [Term] id: GO:0008177 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function alt_id: GO:0019737 def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13713] synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: KEGG_REACTION:R02164 xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN xref: Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:R-HSA-70994 "Succinate <=> Fumarate (with FAD redox reaction on enzyme)" xref: RHEA:13713 is_a: GO:0000104 ! succinate dehydrogenase activity is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0008179 name: adenylate cyclase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl] synonym: "adenylyl cyclase binding" EXACT [] xref: Reactome:R-HSA-170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0008180 name: COP9 signalosome namespace: cellular_component def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] synonym: "COP9 complex" EXACT [GOC:krc] synonym: "CSN" EXACT [] synonym: "signalosome" BROAD [GOC:krc] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0008181 name: obsolete tumor suppressor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. synonym: "tumor suppressor" EXACT [] is_obsolete: true consider: GO:0051726 [Term] id: GO:0008184 name: glycogen phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] xref: MetaCyc:GLYCOPHOSPHORYL-RXN xref: Reactome:R-HSA-453339 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]" xref: Reactome:R-HSA-453358 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" xref: Reactome:R-HSA-71515 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" xref: Reactome:R-HSA-71590 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]" is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0008186 name: RNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004010 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008187 name: poly-pyrimidine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: has_part GO:0042923 ! neuropeptide binding relationship: part_of GO:0007218 ! neuropeptide signaling pathway [Term] id: GO:0008189 name: obsolete apoptosis inhibitor activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0043066 [Term] id: GO:0008190 name: eukaryotic initiation factor 4E binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732] synonym: "eIF4E binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0008191 name: metalloendopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] synonym: "metalloprotease inhibitor" NARROW [] synonym: "metalloproteinase inhibitor" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0004222 ! metalloendopeptidase activity [Term] id: GO:0008192 name: RNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008193 name: tRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] xref: EC:2.7.7.79 xref: RHEA:54564 is_a: GO:0008192 ! RNA guanylyltransferase activity relationship: part_of GO:0099116 ! tRNA 5'-end processing [Term] id: GO:0008194 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] xref: Reactome:R-HSA-162730 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008195 name: phosphatidate phosphatase activity namespace: molecular_function alt_id: GO:0004606 def: "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr] synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "phosphatidate phosphohydrolase activity" EXACT [] synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] xref: EC:3.1.3.4 xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN xref: Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN" xref: Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A" xref: Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A" xref: Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex" xref: Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 568) by PP2A" xref: Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1" xref: Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A" xref: Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol" xref: Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA" xref: Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate" xref: RHEA:27429 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008196 name: vitellogenin receptor activity namespace: molecular_function def: "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis." [GOC:bf, PMID:12429745] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0008197 name: obsolete yolk protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "yolk protein" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0045735 [Term] id: GO:0008198 name: ferrous iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai] is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008199 name: ferric iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008200 name: ion channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] is_a: GO:0016248 ! channel inhibitor activity is_a: GO:0099106 ! ion channel regulator activity [Term] id: GO:0008201 name: heparin binding namespace: molecular_function def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] synonym: "heparan sulfate binding" RELATED [] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] synonym: "steroid metabolism" EXACT [] xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0008203 name: cholesterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732] synonym: "cholesterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008204 name: ergosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732] synonym: "ergosterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008205 name: ecdysone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732] synonym: "ecdysone metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0045455 ! ecdysteroid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0008207 name: C21-steroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008208 name: C21-steroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone breakdown" EXACT [] synonym: "C21-steroid hormone catabolism" EXACT [] synonym: "C21-steroid hormone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0008209 name: androgen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008210 name: estrogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen metabolism" EXACT [] synonym: "oestrogen metabolic process" EXACT [] synonym: "oestrogen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008211 name: glucocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732] synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0008212 name: mineralocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732] synonym: "mineralocorticoid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008213 name: protein alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: goslim_yeast synonym: "protein amino acid alkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0008214 name: protein dealkylation namespace: biological_process def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai] synonym: "protein amino acid dealkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0008215 name: spermine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:curators] synonym: "spermine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0008216 name: spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] synonym: "spermidine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: MIPS_funcat:02.45.01 xref: Wikipedia:Bioluminescence is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] xref: MIPS_funcat:40.10 is_a: GO:0009987 ! cellular process [Term] id: GO:0008220 name: obsolete necrosis namespace: biological_process def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. synonym: "necrosis" EXACT [] is_obsolete: true consider: GO:0001906 consider: GO:0008219 consider: GO:0012501 consider: GO:0019835 consider: GO:0070265 [Term] id: GO:0008222 name: obsolete tumor antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "tumor antigen" EXACT [] is_obsolete: true [Term] id: GO:0008224 name: obsolete Gram-positive antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "Gram-positive antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050830 [Term] id: GO:0008225 name: obsolete Gram-negative antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "Gram-negative antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050829 [Term] id: GO:0008226 name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [GOC:curators] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0008227 name: G protein-coupled amine receptor activity namespace: molecular_function def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "biogenic amine receptor" NARROW [] synonym: "G-protein coupled amine receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008228 name: opsonization namespace: biological_process def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] xref: Wikipedia:Opsonin is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0008229 name: obsolete opsonin activity namespace: molecular_function def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "opsonin activity" EXACT [] is_obsolete: true consider: GO:0003823 [Term] id: GO:0008230 name: ecdysone receptor holocomplex namespace: cellular_component def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] is_a: GO:0043235 ! receptor complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0008231 name: repressor ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] synonym: "repressor ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008232 name: activator ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] synonym: "activator ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006508 ! proteolysis [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "cysteine protease activity" NARROW [] synonym: "thiol protease activity" NARROW [] xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008235 name: metalloexopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] is_a: GO:0008237 ! metallopeptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008236 name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine protease activity" NARROW [] xref: Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin" xref: Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:Cbl" xref: Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)" is_a: GO:0017171 ! serine hydrolase activity is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008237 name: metallopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "metalloprotease activity" NARROW [GOC:mah] synonym: "metalloproteinase activity" NARROW [GOC:mah] xref: Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2" xref: Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1" xref: Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain" xref: Reactome:R-HSA-2022368 "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)" xref: Reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)" xref: Reactome:R-HSA-2022396 "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)" xref: Reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)" xref: Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants" xref: Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding" xref: Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1" xref: Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding" xref: Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs" xref: Reactome:R-HSA-5211340 "Anthrax LF cleaves target cell MAP2K1 (MEK1)" xref: Reactome:R-HSA-5211356 "Anthrax LF cleaves target cell MAP2K2 (MEK2)" xref: Reactome:R-HSA-5211387 "Anthrax LF cleaves target cell MAP2K7 (MEK7)" xref: Reactome:R-HSA-5211391 "Anthrax LF cleaves target cell MAP2K4 (MEK4)" xref: Reactome:R-HSA-5211400 "Anthrax LF cleaves target cell MAP2K3 (MEK3)" xref: Reactome:R-HSA-5211405 "Anthrax LF cleaves target cell MAP2K6 (MEK6)" xref: Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)" xref: Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3" xref: Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008238 name: exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] synonym: "exoprotease activity" NARROW [] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008239 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] is_a: GO:0004177 ! aminopeptidase activity [Term] id: GO:0008240 name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14 xref: MetaCyc:3.4.14.10-RXN xref: MetaCyc:3.4.14.9-RXN is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008241 name: peptidyl-dipeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] xref: EC:3.4.15 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008242 name: omega peptidase activity namespace: molecular_function def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] xref: EC:3.4.19 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008243 name: obsolete plasminogen activator activity namespace: molecular_function alt_id: GO:0004296 alt_id: GO:0004297 def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] comment: This term was made obsolete because it represents a gene product. synonym: "abbokinase activity" EXACT [EC:3.4.21.68] synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "plasminogen activator activity" EXACT [] synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] synonym: "t-PA" RELATED [EC:3.4.21.68] synonym: "t-plasminogen activator activity" NARROW [] synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] synonym: "tPA activity" NARROW [EC:3.4.21.-] synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "u-PA" RELATED [EC:3.4.21.68] synonym: "u-plasminogen activator activity" NARROW [] synonym: "uPA" RELATED [EC:3.4.21.68] synonym: "urinary esterase A" RELATED [EC:3.4.21.68] synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] xref: EC:3.4.21.68 xref: EC:3.4.21.73 xref: MetaCyc:3.4.21.68-RXN xref: MetaCyc:3.4.21.73-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008245 name: obsolete lysosomal membrane hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "lysosomal membrane hydrogen-transporting ATPase" EXACT [] synonym: "V-ATPase" RELATED [] is_obsolete: true consider: GO:0046611 [Term] id: GO:0008246 name: obsolete electron transfer flavoprotein namespace: molecular_function def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein" EXACT [] synonym: "ETF" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008247 name: 1-alkyl-2-acetylglycerophosphocholine esterase complex namespace: cellular_component def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT [] synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0008248 name: obsolete pre-mRNA splicing factor activity namespace: molecular_function def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] comment: This term was made obsolete because it describes a biological process. synonym: "pre-mRNA splicing factor activity" EXACT [] is_obsolete: true consider: GO:0008380 [Term] id: GO:0008250 name: oligosaccharyltransferase complex namespace: cellular_component def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] synonym: "oligosaccharyl transferase complex" EXACT [] synonym: "OST complex" EXACT [] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0008251 name: tRNA-specific adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] synonym: "tRNA-adenosine deaminase activity" EXACT [] xref: Reactome:R-HSA-6782311 "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs" xref: Reactome:R-HSA-6782336 "ADAT1 deaminates adenosine-37 in tRNA(Ala)" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0008252 name: nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] synonym: "NSP I" RELATED [EC:3.1.3.31] synonym: "NSP II" RELATED [EC:3.1.3.31] synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: MetaCyc:NUCLEOTIDASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008253 name: 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] synonym: "5' nucleotidase activity" EXACT [] synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] synonym: "5'-AMPase" NARROW [EC:3.1.3.5] synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] synonym: "AMPase" NARROW [EC:3.1.3.5] synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] synonym: "UMPase" NARROW [EC:3.1.3.5] synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] xref: EC:3.1.3.5 xref: MetaCyc:5-NUCLEOTID-RXN xref: Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP" xref: Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]" xref: Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)" xref: Reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)" xref: Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]" xref: Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)" xref: Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)" xref: Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]" xref: Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]" xref: Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG" xref: Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)" xref: Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+" xref: Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008254 name: 3'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] synonym: "3' nucleotidase activity" EXACT [] synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: MetaCyc:3-NUCLEOTID-RXN is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008255 name: ecdysis-triggering hormone activity namespace: molecular_function def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008256 name: protein histidine pros-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: MetaCyc:2.7.13.1-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008257 name: protein histidine tele-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: MetaCyc:2.7.13.2-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008258 name: head involution namespace: biological_process def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:0879694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0008259 name: obsolete transforming growth factor beta ligand binding to type I receptor namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type I receptor" EXACT [] synonym: "TGFbeta ligand binding to type I receptor" EXACT [] synonym: "transforming growth factor beta ligand binding to type I receptor" EXACT [] is_obsolete: true consider: GO:0005025 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0008260 name: 3-oxoacid CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] xref: EC:2.8.3.5 xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN xref: Reactome:R-HSA-74177 "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA" xref: RHEA:25480 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008261 name: allatostatin receptor activity namespace: molecular_function def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0008263 name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0008265 name: Mo-molybdopterin cofactor sulfurase activity namespace: molecular_function def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] synonym: "molybdopterin cofactor sulfurase activity" EXACT [] synonym: "molybdopterin synthase sulfurylase activity" EXACT [] xref: EC:2.8.1.9 xref: Reactome:R-HSA-947499 "Exchange of oxygen with sulfur in MoCo" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0008266 name: poly(U) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] synonym: "poly(U) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0008267 name: poly-glutamine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0008268 name: obsolete receptor signaling protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein tyrosine kinase signaling protein activity" EXACT [] synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0008269 name: JAK pathway signal transduction adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0035591 ! signaling adaptor activity relationship: part_of GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT [Term] id: GO:0008270 name: zinc ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] synonym: "zinc binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0008271 name: secondary active sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] synonym: "sulfate porter activity" RELATED [] synonym: "sulphate porter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0008272 name: sulfate transport namespace: biological_process alt_id: GO:0006870 def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphate transport" EXACT [] xref: MIPS_funcat:20.01.01.07.05 is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0008273 name: calcium, potassium:sodium antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: Reactome:R-HSA-2514891 "SLC24A1 exchanges 4Na+ for Ca2+, K+" xref: Reactome:R-HSA-425678 "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+" xref: Reactome:R-HSA-5625841 "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+" xref: Reactome:R-HSA-5626270 "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+" xref: Reactome:R-HSA-5626316 "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+" xref: Reactome:R-HSA-5626356 "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+" is_a: GO:0005432 ! calcium:sodium antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0008274 name: gamma-tubulin ring complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] synonym: "gammaTuRC" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex [Term] id: GO:0008275 name: gamma-tubulin small complex namespace: cellular_component def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] synonym: "gammaTuSC" EXACT [] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0008276 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] xref: Reactome:R-HSA-9632182 "PRMT1 methylates ESRs" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006479 ! protein methylation [Term] id: GO:0008277 name: regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0008278 name: cohesin complex namespace: cellular_component alt_id: GO:0008279 alt_id: GO:0008280 alt_id: GO:0043222 def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095] subset: goslim_pir synonym: "14S cohesin" NARROW [] synonym: "9S cohesin" NARROW [] synonym: "cohesin core heterodimer" RELATED [] synonym: "SMC complex" RELATED [] synonym: "SMC/kleisin ring complex" EXACT [] synonym: "Smc1-Smc3 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0008281 name: sulfonylurea receptor activity namespace: molecular_function def: "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. synonym: "sulphonylurea receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008282 name: inward rectifying potassium channel namespace: cellular_component def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity." [GOC:bhm, PMID:16308567, PMID:16956886] synonym: "ATP-sensitive potassium channel complex" EXACT [] synonym: "inward rectifying K+ channel" EXACT [] synonym: "KCNJ11-SUR complex" RELATED [] synonym: "KCNJ11-SURx complex" RELATED [] synonym: "KCNJ8-SUR complex" RELATED [] synonym: "KCNJ8-SURx complex" RELATED [] synonym: "Kir6-SUR complex" RELATED [] synonym: "Kir6.1-SUR complex" RELATED [] synonym: "Kir6.1-SURx complex" RELATED [] synonym: "Kir6.2-SUR complex" RELATED [] synonym: "Kir6.2-SURx complex" RELATED [] synonym: "Kir6.x complex" RELATED [] synonym: "Kir6.x-SURx complex" RELATED [] is_a: GO:0034705 ! potassium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008283 ! cell population proliferation relationship: positively_regulates GO:0008283 ! cell population proliferation [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008283 ! cell population proliferation relationship: negatively_regulates GO:0008283 ! cell population proliferation [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.12.05 is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0032869 ! cellular response to insulin stimulus [Term] id: GO:0008287 name: protein serine/threonine phosphatase complex namespace: cellular_component def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] subset: goslim_pir is_a: GO:1903293 ! phosphatase complex [Term] id: GO:0008288 name: boss receptor activity namespace: molecular_function def: "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:jl, GOC:signaling] synonym: "sevenless receptor activity" RELATED [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: MIPS_funcat:16.09 is_a: GO:0005488 ! binding [Term] id: GO:0008290 name: F-actin capping protein complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1900619 ! acetate ester metabolic process [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process [Term] id: GO:0008293 name: torso signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] synonym: "torso signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008294 name: calcium- and calmodulin-responsive adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] xref: Reactome:R-HSA-111930 "Adenylate cyclase produces cAMP" xref: Reactome:R-HSA-442715 "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP" is_a: GO:0004016 ! adenylate cyclase activity [Term] id: GO:0008295 name: spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732] synonym: "spermidine anabolism" EXACT [] synonym: "spermidine biosynthesis" EXACT [] synonym: "spermidine formation" EXACT [] synonym: "spermidine synthesis" EXACT [] xref: MetaCyc:BSUBPOLYAMSYN-PWY xref: MetaCyc:POLYAMINSYN3-PWY is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0008296 name: 3'-5'-exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] xref: Reactome:R-HSA-9023943 "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008297 name: single-stranded DNA exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008298 name: intracellular mRNA localization namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] synonym: "intracellular mRNA localisation" EXACT [GOC:mah] synonym: "intracellular mRNA positioning" NARROW [] synonym: "mRNA localization, intracellular" EXACT [] synonym: "mRNA positioning, intracellular" NARROW [] is_a: GO:0006403 ! RNA localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY xref: MIPS_funcat:01.06.01 xref: MIPS_funcat:01.06.01.07 is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008300 name: isoprenoid catabolic process namespace: biological_process alt_id: GO:0016097 def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid breakdown" EXACT [] synonym: "isoprenoid catabolism" EXACT [] synonym: "isoprenoid degradation" EXACT [] synonym: "polyisoprenoid breakdown" NARROW [] synonym: "polyisoprenoid catabolic process" NARROW [] synonym: "polyisoprenoid catabolism" NARROW [] synonym: "polyisoprenoid degradation" NARROW [] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] xref: MIPS_funcat:01.06.04 xref: MIPS_funcat:01.06.04.07 is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0008301 name: DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] synonym: "DNA bending activity" EXACT [] synonym: "DNA bending involving DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0008302 name: female germline ring canal formation, actin assembly namespace: biological_process def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] synonym: "nurse cell ring canal formation, actin assembly" NARROW [] synonym: "ovarian ring canal formation, actin assembly" NARROW [] synonym: "ring canal formation, actin assembly" BROAD [] is_a: GO:0007015 ! actin filament organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007301 ! female germline ring canal formation [Term] id: GO:0008303 name: caspase complex namespace: cellular_component def: "A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes." [GOC:cna, GOC:mtg_apoptosis, PMID:15569692] comment: Note that this term was reinstated from obsolete. synonym: "cysteine-type endopeptidase complex" EXACT [GOC:pr] is_a: GO:1905369 ! endopeptidase complex [Term] id: GO:0008304 name: obsolete eukaryotic translation initiation factor 4 complex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "eIF-4" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" EXACT [] is_obsolete: true replaced_by: GO:0016281 [Term] id: GO:0008305 name: integrin complex namespace: cellular_component def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] synonym: "laminin receptor protein" RELATED [] is_a: GO:0098636 ! protein complex involved in cell adhesion is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008307 name: structural constituent of muscle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008308 name: voltage-gated anion channel activity namespace: molecular_function alt_id: GO:0022844 def: "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729] synonym: "voltage-dependent ion-selective channel activity" RELATED [] synonym: "voltage-gated ion-selective channel activity" RELATED [] xref: Reactome:R-HSA-9012374 "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space" is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005253 ! anion channel activity [Term] id: GO:0008309 name: double-stranded DNA exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] synonym: "double-stranded DNA specific exodeoxyribonuclease activity" RELATED [] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008310 name: single-stranded DNA 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] synonym: "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity [Term] id: GO:0008311 name: double-stranded DNA 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] synonym: "double-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity [Term] id: GO:0008312 name: 7S RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] is_a: GO:0003723 ! RNA binding [Term] id: GO:0008313 name: gurken-activated receptor activity namespace: molecular_function def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] synonym: "gurken receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0005006 ! epidermal growth factor-activated receptor activity [Term] id: GO:0008314 name: gurken signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf, PMID:23972992] synonym: "gurken receptor signaling pathway" EXACT [] synonym: "gurken receptor signalling pathway" EXACT [] synonym: "gurken-activated signaling pathway" RELATED [GOC:signaling] synonym: "signaling by Gurken" EXACT [GOC:bf] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0008315 name: G2/MI transition of meiotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480] synonym: "meiotic cell cycle G2/MI phase transition" EXACT [] synonym: "meiotic G2/MI phase transition" EXACT [] synonym: "meiotic G2/MI transition" EXACT [] is_a: GO:0044771 ! meiotic cell cycle phase transition is_a: GO:0044839 ! cell cycle G2/M phase transition is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0008316 name: structural constituent of vitelline membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008317 name: gurken receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai] synonym: "gurken receptor ligand" NARROW [] is_a: GO:0005154 ! epidermal growth factor receptor binding [Term] id: GO:0008318 name: protein prenyltransferase activity namespace: molecular_function alt_id: GO:0008244 def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] is_a: GO:0004659 ! prenyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008319 name: obsolete prenyl protein specific endopeptidase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "prenyl protein specific endopeptidase activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function alt_id: GO:0015266 alt_id: GO:0015463 def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] synonym: "protein channel activity" RELATED [] xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix" xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: Reactome:R-HSA-5210943 "PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)" xref: Reactome:R-HSA-5210947 "PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol)" xref: Reactome:R-HSA-5228406 "TeNT HC transports TeNT LC from target cell endosome membrane into cytosol" xref: Reactome:R-HSA-5244404 "BoNT/B HC transports BoNT/B LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244428 "BoNT/A HC transports BoNT/A LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244506 "BoNT/E HC transports BoNT/E LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5246514 "BoNT/C HC transports BoNT/C LC from target cell synaptic vesicle membrane to cytosol" xref: Reactome:R-HSA-5250616 "BoNT/D HC transports BoNT/D LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250884 "BoNT/F HC transports BoNT/F LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250972 "BoNT/G HC transports BoNT/G LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0140318 ! protein transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0071806 ! protein transmembrane transport [Term] id: GO:0008321 name: Ral guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0016220 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Ral GDP-dissociation stimulator activity" EXACT [] xref: Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017160 ! Ral GTPase binding [Term] id: GO:0008322 name: obsolete Pro-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "Pro-X carboxypeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008324 name: cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "transmembrane cation transporter activity" EXACT [] xref: MIPS_funcat:20.01.01.01 is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0098655 ! cation transmembrane transport [Term] id: GO:0008327 name: methyl-CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] is_a: GO:0000166 ! nucleotide binding is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0008328 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] is_a: GO:0034702 ! ion channel complex is_a: GO:0098878 ! neurotransmitter receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008330 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008331 name: high voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] synonym: "high voltage gated calcium channel activity" EXACT [] synonym: "high voltage-dependent calcium channel activity" EXACT [] synonym: "L-type calcium channel" RELATED [] synonym: "N-type calcium channel" RELATED [] synonym: "P-type calcium channel" RELATED [] synonym: "Q-type calcium channel" RELATED [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008332 name: low voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] synonym: "low voltage gated calcium channel activity" EXACT [] synonym: "low voltage-dependent calcium channel activity" EXACT [] synonym: "T-type calcium channel" RELATED [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008333 name: endosome to lysosome transport namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] is_a: GO:0007041 ! lysosomal transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0008334 name: histone mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393] comment: In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated. synonym: "histone mRNA metabolism" EXACT [] synonym: "stem-loop-containing histone mRNA 3'-end processing" NARROW [GOC:krc, GOC:mah, PMID:17855393] is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0008335 name: female germline ring canal stabilization namespace: biological_process def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] synonym: "nurse cell ring canal stabilization" NARROW [] synonym: "ovarian ring canal stabilization" NARROW [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0008336 name: gamma-butyrobetaine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24028] synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "g-butyrobetaine dioxygenase activity" EXACT [] synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: KEGG_REACTION:R02397 xref: MetaCyc:1.14.11.1-RXN xref: Reactome:R-HSA-71261 "BBOX1:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA" xref: RHEA:24028 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0008337 name: obsolete selectin namespace: molecular_function def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] comment: This term was made obsolete because it describes a class of gene products. synonym: "selectin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0008340 name: determination of adult lifespan namespace: biological_process def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010259 ! multicellular organism aging [Term] id: GO:0008341 name: obsolete response to cocaine (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "response to cocaine (sensu Insecta)" EXACT [] is_obsolete: true consider: GO:0048148 [Term] id: GO:0008342 name: obsolete larval feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. synonym: "larval feeding behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008343 name: adult feeding behavior namespace: biological_process def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "adult feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008344 name: adult locomotory behavior namespace: biological_process def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "adult locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008345 name: larval locomotory behavior namespace: biological_process def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "larval locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0008346 name: larval walking behavior namespace: biological_process def: "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators, GOC:pr] synonym: "larval walking behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior is_a: GO:0090659 ! walking behavior [Term] id: GO:0008347 name: glial cell migration namespace: biological_process alt_id: GO:0043359 def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0008348 name: negative regulation of antimicrobial humoral response namespace: biological_process alt_id: GO:0042154 alt_id: GO:0042155 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] synonym: "attenuation of antimicrobial humoral response" EXACT [] synonym: "down regulation of antimicrobial humoral response" EXACT [] synonym: "down-regulation of antimicrobial humoral response" EXACT [] synonym: "downregulation of antimicrobial humoral response" EXACT [] synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019730 ! antimicrobial humoral response relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0008349 name: MAP kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] synonym: "MAP4K activity" EXACT [PMID:20811974] synonym: "MAPKKKK" EXACT [] xref: Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex" xref: Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0000165 ! MAPK cascade relationship: part_of GO:0000185 ! activation of MAPKKK activity [Term] id: GO:0008350 name: obsolete kinetochore motor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. synonym: "kinetochore motor activity" EXACT [] is_obsolete: true consider: GO:0000776 consider: GO:0003777 [Term] id: GO:0008351 name: obsolete microtubule severing activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "microtubule severing activity" EXACT [] is_obsolete: true consider: GO:0008017 consider: GO:0051013 [Term] id: GO:0008352 name: katanin complex namespace: cellular_component def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0005815 ! microtubule organizing center [Term] id: GO:0008353 name: RNA polymerase II CTD heptapeptide repeat kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] synonym: "CTD kinase activity" EXACT [EC:2.7.11.23] synonym: "RNA polymerase II carboxy-terminal domain kinase activity" EXACT [] synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN xref: Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex" xref: Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex" xref: Reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "primordial germ cell migration" RELATED [] is_a: GO:0016477 ! cell migration is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008358 name: maternal determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0008359 name: regulation of bicoid mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1902875 ! regulation of embryonic pattern specification is_a: GO:1903429 ! regulation of cell maturation is_a: GO:1904580 ! regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045450 ! bicoid mRNA localization relationship: regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0008360 name: regulation of cell shape namespace: biological_process alt_id: GO:0045788 alt_id: GO:0045789 def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] synonym: "cell size control" EXACT [] xref: MIPS_funcat:40.01.05 is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008362 name: chitin-based embryonic cuticle biosynthetic process namespace: biological_process def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] synonym: "embryonic cuticle anabolism" BROAD [] synonym: "embryonic cuticle biosynthetic process" BROAD [] synonym: "embryonic cuticle formation" BROAD [] synonym: "embryonic cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008363 name: larval chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "larval cuticle anabolism" BROAD [] synonym: "larval cuticle biosynthetic process" BROAD [] synonym: "larval cuticle formation" BROAD [] synonym: "larval cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0008364 name: pupal chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "pupal cuticle anabolism" BROAD [] synonym: "pupal cuticle formation" BROAD [] synonym: "pupal cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0008365 name: adult chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "adult chitin-based cuticle anabolism" EXACT [] synonym: "adult chitin-based cuticle biosynthetic process" EXACT [] synonym: "adult chitin-based cuticle formation" EXACT [] synonym: "adult chitin-based cuticle synthesis" EXACT [] synonym: "adult cuticle anabolism" BROAD [] synonym: "adult cuticle biosynthetic process" BROAD [] synonym: "adult cuticle formation" BROAD [] synonym: "adult cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process alt_id: GO:0042553 def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0008369 name: obsolete molecular function namespace: molecular_function def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008370 name: obsolete cellular component namespace: cellular_component def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008371 name: obsolete biological process namespace: biological_process def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008373 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [EC:2.4.99, GOC:cjm, Wikipedia:Sialyltransferase] xref: EC:2.4.99 xref: Reactome:R-HSA-981814 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups relationship: part_of GO:0097503 ! sialylation [Term] id: GO:0008374 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: Reactome:R-HSA-1482775 "MLCL is acylated to CL by HADH (IM)" xref: Reactome:R-HSA-1482781 "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)" xref: Reactome:R-HSA-1482850 "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)" xref: Reactome:R-HSA-1482861 "MLCL is acylated to CL by LCLAT1 (ER)" xref: Reactome:R-HSA-1482867 "DLCL is acylated to MLCL by LCLAT1 (ER)" xref: Reactome:R-HSA-162683 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH" xref: Reactome:R-HSA-3238694 "PORCN palmitoleoylates N-glycosyl WNTs" xref: Reactome:R-HSA-422017 "Ghrelin O-acyltransferase decanoylates Proghrelin" xref: Reactome:R-HSA-422104 "Ghrelin O-acyltransferase octanoylates Proghrelin" xref: Reactome:R-HSA-5358343 "HHAT palmitoylates Hh N-terminal fragment" xref: Reactome:R-HSA-5483229 "HHAT G287V doesn't palmitoylate Hh-Np" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008375 name: acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] synonym: "GlcNAc transferase activity" EXACT [] xref: MetaCyc:2.4.1.223-RXN xref: Reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins" xref: Reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008376 name: acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] synonym: "GalNAc transferase activity" EXACT [] xref: Reactome:R-HSA-8855954 "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD" xref: Reactome:R-HSA-8931648 "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1" xref: Reactome:R-HSA-9605700 "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008377 name: light-induced release of internally sequestered calcium ion namespace: biological_process def: "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] synonym: "light-induced release of calcium from internal store" EXACT [] synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0008378 name: galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] xref: MetaCyc:2.4.1.151-RXN xref: Reactome:R-HSA-1964501 "Addition of galactose to Core 6 glycoprotein" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008379 name: thioredoxin peroxidase activity namespace: molecular_function alt_id: GO:0009031 def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1 xref: MetaCyc:RXN0-267 xref: Reactome:R-HSA-2161612 "PGH2 is reduced to PGF2a by FAM213B" xref: Reactome:R-HSA-3322995 "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O" xref: Reactome:R-HSA-3341343 "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O" xref: Reactome:R-HSA-3697882 "PRDX5 reduces peroxynitrite to nitrite using TXN" xref: Reactome:R-HSA-3697894 "PRDX5 reduces peroxynitrite to nitrite using TXN2" is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0008380 name: RNA splicing namespace: biological_process alt_id: GO:0006395 def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] subset: goslim_yeast synonym: "pre-mRNA splicing factor activity" RELATED [] xref: MIPS_funcat:11.04.03.01 xref: Wikipedia:RNA_splicing is_a: GO:0006396 ! RNA processing [Term] id: GO:0008381 name: mechanosensitive ion channel activity namespace: molecular_function alt_id: GO:0022833 def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] synonym: "mechanically gated channel activity" EXACT [] synonym: "mechanically-gated channel activity" EXACT [] synonym: "mechanically-gated ion channel activity" EXACT [] is_a: GO:0005216 ! ion channel activity is_a: GO:0022836 ! gated channel activity [Term] id: GO:0008384 name: IkappaB kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] synonym: "CHUK" RELATED [EC:2.7.11.10] synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "IKBKA" RELATED [EC:2.7.11.10] synonym: "IKBKB" RELATED [EC:2.7.11.10] synonym: "IKK" RELATED [EC:2.7.11.10] synonym: "IKK-1" RELATED [EC:2.7.11.10] synonym: "IKK-2" RELATED [EC:2.7.11.10] synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "STK12" RELATED [EC:2.7.11.10] synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] synonym: "TBK1" RELATED [EC:2.7.11.10] xref: EC:2.7.11.10 xref: MetaCyc:2.7.11.10-RXN xref: Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex" xref: Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0007252 ! I-kappaB phosphorylation [Term] id: GO:0008385 name: IkappaB kinase complex namespace: cellular_component def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203] synonym: "heterotrimeric IKK complex" EXACT [GOC:bf] synonym: "IKK complex" EXACT [] synonym: "trimeric IKK complex" EXACT [PMID:21173796] is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0008386 name: cholesterol monooxygenase (side-chain-cleaving) activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] synonym: "Cyp11a1" NARROW [] synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] xref: EC:1.14.15.6 xref: MetaCyc:1.14.15.6-RXN xref: Reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol" xref: Reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol" xref: Reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008387 name: steroid 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP2A12" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008388 name: testosterone 15-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2A4" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008389 name: coumarin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] synonym: "cytochrome P450 CYP2A5" NARROW [] xref: Reactome:R-HSA-211881 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:R-HSA-76453 "Coumarin is 7-hydroxylated by CYP2A6" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008390 name: testosterone 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2B10" NARROW [] synonym: "cytochrome P450 CYP2B9" NARROW [] synonym: "cytochrome P450 CYP2D10" NARROW [] synonym: "cytochrome P450 CYP2D11" NARROW [] synonym: "cytochrome P450 CYP2D9" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008391 name: arachidonic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah] synonym: "cytochrome P450 CYP2B19" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008392 name: arachidonic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2J5" NARROW [] synonym: "cytochrome P450 CYP2J6" NARROW [] xref: Reactome:R-HSA-211983 "CYP2J2 oxidises ARA" is_a: GO:0008391 ! arachidonic acid monooxygenase activity [Term] id: GO:0008395 name: steroid hydroxylase activity namespace: molecular_function alt_id: GO:0008394 def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544] synonym: "cytochrome P450 CYP2G1" NARROW [] synonym: "olfactory-specific steroid hydroxylase activity" NARROW [] xref: Reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol" xref: Reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol" xref: Reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al" xref: Reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)" xref: Reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL" xref: Reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1" xref: Reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b" xref: Reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol" xref: Reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)" xref: Reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al" xref: Reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)" xref: Reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al" xref: Reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)" xref: Reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al" xref: Reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol" xref: Reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol" xref: Reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO" xref: Reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST" xref: Reactome:R-HSA-5601849 "Defective CYP19A1 does not convert ANDST to E1" xref: Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol" xref: Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST" xref: Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST" xref: Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol" is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0008396 name: oxysterol 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] synonym: "cytochrome P450 CYP7B1" NARROW [] xref: Reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated" xref: Reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL" xref: Reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL" xref: Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008397 name: sterol 12-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP8B1" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008398 name: sterol 14-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] synonym: "cytochrome P450 CYP51" NARROW [] synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] xref: EC:1.14.13.70 xref: MetaCyc:1.14.13.70-RXN xref: Reactome:R-HSA-194678 "CYP51A1 demethylates LNSOL" xref: RHEA:14917 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0008399 name: naphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702] synonym: "cytochrome P450 CYP2F2" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008401 name: retinoic acid 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282, PMID:9250660] synonym: "cytochrome P450 CYP261" NARROW [] xref: Reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA" xref: Reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA" xref: Reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA" xref: Reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA" xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA" xref: Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008403 name: 25-hydroxycholecalciferol-24-hydroxylase activity namespace: molecular_function alt_id: GO:0030344 def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309] synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] synonym: "cytochrome P450 CYP24" NARROW [] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0008404 name: arachidonic acid 14,15-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C29" NARROW [] synonym: "cytochrome P450 CYP2C39" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008405 name: arachidonic acid 11,12-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C38" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] synonym: "gonadogenesis" EXACT [GOC:cjm] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0045137 ! development of primary sexual characteristics [Term] id: GO:0008407 name: chaeta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] synonym: "bristle morphogenesis" NARROW [GOC:bf, GOC:dos] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0022416 ! chaeta development [Term] id: GO:0008408 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] synonym: "3'-5'-exonuclease activity" EXACT [] xref: Reactome:R-HSA-3245943 "Viral DNA cleavage by TREX1" is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008409 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] xref: Reactome:R-HSA-5358599 "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch" xref: Reactome:R-HSA-5358619 "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)" is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008410 name: CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] xref: EC:2.8.3 xref: Reactome:R-HSA-70713 "BCKDH transfers CoA group from CoA-SH to BCAAs" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008411 name: 4-hydroxybutyrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008412 name: 4-hydroxybenzoate octaprenyltransferase activity namespace: molecular_function alt_id: GO:0000043 alt_id: GO:0048043 alt_id: GO:0048044 def: "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] synonym: "4-HB polyprenyltransferase activity" EXACT [] synonym: "para-hydroxybenzoate transferase activity" EXACT [] synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0008413 name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881] synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT [] synonym: "8-oxo-GTPase activity" EXACT [] xref: EC:3.6.1 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008414 name: CDP-alcohol phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0008417 name: fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] xref: Reactome:R-HSA-9033949 "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups relationship: part_of GO:0036065 ! fucosylation [Term] id: GO:0008418 name: protein-N-terminal asparagine amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008419 name: RNA lariat debranching enzyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008420 name: RNA polymerase II CTD heptapeptide repeat phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate." [PMID:22622228] synonym: "CTD phosphatase activity" EXACT [] synonym: "RNA polymerase II carboxy-terminal domain phosphatase activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0008421 name: long-chain fatty-acyl-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: MetaCyc:3.5.1.55-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008422 name: beta-glucosidase activity namespace: molecular_function alt_id: GO:0016983 def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] synonym: "amygdalase activity" NARROW [EC:3.2.1.21] synonym: "amygdalinase" BROAD [EC:3.2.1.21] synonym: "arbutinase activity" EXACT [EC:3.2.1.21] synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "cellobiase activity" NARROW [EC:3.2.1.21] synonym: "cytokine beta-glucosidase activity" NARROW [] synonym: "elaterase activity" NARROW [EC:3.2.1.21] synonym: "emulsin" RELATED [EC:3.2.1.21] synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] synonym: "gentobiase activity" NARROW [EC:3.2.1.21] synonym: "limarase activity" NARROW [EC:3.2.1.21] synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] synonym: "salicilinase activity" NARROW [EC:3.2.1.21] xref: EC:3.2.1.21 xref: MetaCyc:3.2.1.21-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0008423 name: obsolete bleomycin hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] synonym: "bleomycin hydrolase activity" EXACT [] xref: EC:3.4.22.40 xref: MetaCyc:3.4.22.40-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008424 name: glycoprotein 6-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+)." [EC:2.4.1.68, RHEA:12985] synonym: "FucT" RELATED [EC:2.4.1.68] synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] xref: EC:2.4.1.68 xref: KEGG_REACTION:R05988 xref: MetaCyc:2.4.1.68-RXN xref: Reactome:R-HSA-1028788 "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP" xref: RHEA:12985 is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein relationship: part_of GO:0036071 ! N-glycan fucosylation [Term] id: GO:0008425 name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] xref: EC:2.1.1 is_a: GO:0030580 ! quinone cofactor methyltransferase activity [Term] id: GO:0008426 name: protein kinase C inhibitor activity namespace: molecular_function alt_id: GO:0004863 def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT [] synonym: "PKC inhibitor activity" EXACT [] is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0008427 name: calcium-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity [Term] id: GO:0008428 name: ribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004540 ! ribonuclease activity [Term] id: GO:0008429 name: phosphatidylethanolamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0008430 name: selenium binding namespace: molecular_function def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0008431 name: vitamin E binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [ISBN:0721662544] synonym: "alpha-tocopherol binding" NARROW [] synonym: "tocopherol binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0008432 name: JUN kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0008435 name: obsolete anticoagulant activity namespace: molecular_function def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732] comment: This term was made obsolete because it represents a biological process. synonym: "anticoagulant activity" EXACT [] is_obsolete: true replaced_by: GO:0050819 [Term] id: GO:0008436 name: obsolete heterogeneous nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "hnRNP" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0008437 name: thyrotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732] synonym: "thyrotropin releasing hormone activity" EXACT [] synonym: "TRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008438 name: obsolete 1-phosphatidylinositol-5-phosphate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143] comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. synonym: "1-phosphatidylinositol-5-phosphate kinase" EXACT [] is_obsolete: true consider: GO:0016309 [Term] id: GO:0008439 name: obsolete monophenol monooxygenase activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "monophenol monooxygenase activator activity" EXACT [] synonym: "prophenol oxidase activator" RELATED [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008440 name: inositol-1,4,5-trisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11020] synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol trisphosphate 3-kinase activity" EXACT [] synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] synonym: "IP3K activity" NARROW [EC:2.7.1.127] xref: EC:2.7.1.127 xref: KEGG_REACTION:R03433 xref: MetaCyc:2.7.1.127-RXN xref: Reactome:R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol" xref: Reactome:R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus" xref: RHEA:11020 is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0008441 name: 3'(2'),5'-bisphosphate nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "DPNPase activity" EXACT [EC:3.1.3.7] synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] xref: EC:3.1.3.7 xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN xref: Reactome:R-HSA-176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: Reactome:R-HSA-8953499 "IMPAD1 hydrolyses PAP to AMP" xref: RHEA:10040 is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008442 name: 3-hydroxyisobutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] xref: EC:1.1.1.31 xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-508473 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+" xref: Reactome:R-HSA-70885 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+" xref: RHEA:17681 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008443 name: phosphofructokinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl] is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008444 name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12593] synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] xref: EC:2.7.8.5 xref: KEGG_REACTION:R01801 xref: MetaCyc:PHOSPHAGLYPSYN-RXN xref: Reactome:R-HSA-1482939 "CDP-DAG is converted to PGP by PGS1" xref: RHEA:12593 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0008445 name: D-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1] synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] xref: EC:1.4.3.1 xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN xref: Reactome:R-HSA-6810076 "DDO oxidizes D-Asp to OA" xref: RHEA:12512 is_a: GO:0003884 ! D-amino-acid oxidase activity is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008446 name: GDP-mannose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23820] synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "Gmd" RELATED [EC:4.2.1.47] synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] xref: EC:4.2.1.47 xref: KEGG_REACTION:R00888 xref: MetaCyc:GDPMANDEHYDRA-RXN xref: Reactome:R-HSA-6787632 "GMDS dehydrates GDP-Man to GDP-DHDMan" xref: RHEA:23820 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008447 name: L-ascorbate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] synonym: "AAO" RELATED [EC:1.10.3.3] synonym: "ascorbase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] xref: EC:1.10.3.3 xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN xref: RHEA:30243 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008448 name: N-acetylglucosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] xref: EC:3.5.1.25 xref: MetaCyc:NAG6PDEACET-RXN xref: Reactome:R-HSA-6803789 "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA" xref: RHEA:22936 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008449 name: N-acetylglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] xref: EC:3.1.6.14 xref: MetaCyc:3.1.6.14-RXN xref: Reactome:R-HSA-1638032 "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate" xref: Reactome:R-HSA-2263495 "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0008450 name: obsolete O-sialoglycoprotein endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] comment: This term was made obsolete because it represents a gene product. synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "O-sialoglycoprotein endopeptidase activity" EXACT [] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] xref: EC:3.4.24.57 xref: MetaCyc:3.4.24.57-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008451 name: obsolete X-Pro aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "X-Pro aminopeptidase activity" EXACT [] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] xref: EC:3.4.11.9 xref: MetaCyc:3.4.11.9-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0008452 name: RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah] is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0008453 name: alanine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] synonym: "AGT activity" EXACT [EC:2.6.1.44] synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] xref: EC:2.6.1.44 xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-389684 "glyoxylate + alanine => glycine + pyruvate [peroxisome]" xref: Reactome:R-HSA-904864 "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate" xref: RHEA:24248 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008454 name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "GnTIV activity" EXACT [EC:2.4.1.145] synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] xref: EC:2.4.1.145 xref: MetaCyc:2.4.1.145-RXN xref: Reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV" is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0008455 name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTII activity" EXACT [EC:2.4.1.143] synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] xref: EC:2.4.1.143 xref: MetaCyc:2.4.1.143-RXN xref: Reactome:R-HSA-4793955 "Defective MGAT2 does not transfer GlcNAc to N-glycans" xref: Reactome:R-HSA-975829 "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2" xref: RHEA:12941 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0008456 name: alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: MetaCyc:3.2.1.49-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0008457 name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] xref: EC:2.4.1.149 xref: MetaCyc:2.4.1.163-RXN xref: RHEA:23004 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008458 name: carnitine O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17177] synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] xref: EC:2.3.1.137 xref: KEGG_REACTION:R03779 xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN xref: Reactome:R-HSA-390281 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH" xref: RHEA:17177 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity [Term] id: GO:0008459 name: chondroitin 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-sulphotransferase activity" EXACT [] synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] xref: EC:2.8.2.17 xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-2018682 "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains" xref: Reactome:R-HSA-3595175 "Defective CHST3 does not transfer SO4(2-) to chondroitin" xref: RHEA:11108 is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0008460 name: dTDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17221] synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] xref: EC:4.2.1.46 xref: KEGG_REACTION:R06513 xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN xref: RHEA:17221 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008462 name: obsolete endopeptidase Clp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] comment: This term was made obsolete because it represents a gene product. synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] synonym: "Clp protease" NARROW [EC:3.4.21.92] synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Clp activity" EXACT [] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] xref: EC:3.4.21.92 xref: MetaCyc:3.4.21.92-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008463 name: formylmethionine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate." [EC:3.5.1.31, RHEA:17781] synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] xref: EC:3.5.1.31 xref: KEGG_REACTION:R00653 xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN xref: RHEA:17781 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008464 name: obsolete gamma-glutamyl hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] synonym: "conjugase activity" RELATED [EC:3.4.19.9] synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] synonym: "gamma-glutamyl hydrolase activity" EXACT [] synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0008465 name: glycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] xref: EC:1.1.1.29 xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN xref: RHEA:17905 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008466 name: glycogenin glucosyltransferase activity namespace: molecular_function alt_id: GO:0047210 def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "glycogenin activity" RELATED [EC:2.4.1.186] synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] xref: EC:2.4.1.186 xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-3322003 "Autoglucosylation of GYG1 complexed with GYS1-b" xref: Reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a" xref: Reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b" xref: Reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a" xref: Reactome:R-HSA-3814838 "Defective GYG1 is not autoglucosyolated" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008467 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: MetaCyc:2.8.2.23-RXN xref: Reactome:R-HSA-2076383 "HS3ST1 sulfates GlcN at C3 in heparan sulfate" xref: Reactome:R-HSA-2076611 "HS3STs sulfate GlcN at C3 in heparan sulfate" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0008469 name: histone-arginine N-methyltransferase activity namespace: molecular_function alt_id: GO:0016276 def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954] synonym: "histone methyltransferase activity" BROAD [] synonym: "histone protein methylase activity" EXACT [] synonym: "histone protein methylase I" RELATED [] synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [] synonym: "protein methylase I activity" BROAD [] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [] xref: Reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)" xref: Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)" xref: Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)" xref: Reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3" xref: Reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter" xref: Reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter" xref: Reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter" xref: Reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter" is_a: GO:0016274 ! protein-arginine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity relationship: part_of GO:0034969 ! histone arginine methylation [Term] id: GO:0008470 name: isovaleryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.8.4] synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.8.4] synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.8.4] synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.4] synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.4] xref: EC:1.3.8.4 xref: MetaCyc:ISOVALERYL-COA-FAD-RXN xref: Reactome:R-HSA-70745 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2" xref: RHEA:12276 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0008471 name: obsolete laccase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] synonym: "benzenediol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.2] synonym: "laccase activity" EXACT [] synonym: "p-diphenol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urushiol oxidase activity" RELATED [EC:1.10.3.2] is_obsolete: true replaced_by: GO:0016682 [Term] id: GO:0008472 name: obsolete metallocarboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] synonym: "metallocarboxypeptidase D activity" EXACT [] xref: EC:3.4.17.22 xref: MetaCyc:3.4.17.22-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0008473 name: ornithine cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24368] comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] synonym: "OCD activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] xref: EC:4.3.1.12 xref: KEGG_REACTION:R00671 xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN xref: RHEA:24368 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] subset: goslim_chembl synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: Reactome:R-HSA-203613 "depalmitoylation of eNOS" xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins" xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43" is_a: GO:0016790 ! thiolester hydrolase activity is_a: GO:0098599 ! palmitoyl hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008475 name: procollagen-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN xref: Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines" is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2" is_a: GO:0008146 ! sulfotransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008477 name: purine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] synonym: "purine nucleosidase reaction" EXACT [] synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008478 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: MetaCyc:PYRIDOXKIN-RXN xref: Reactome:R-HSA-964958 "2xPDXK:2xZn2+ phosphorylates PXA" xref: Reactome:R-HSA-964962 "2xPDKX:2xZn2+ phosphorylates PDX" xref: Reactome:R-HSA-964970 "2xPDXK:2xZn2+ phosphorylates PXL" xref: RHEA:10224 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008479 name: queuine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0008480 name: sarcosine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.3, RHEA:19793] comment: Note that this was EC:1.5.99.1. synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.8.3] synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.8.3] synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.8.3] synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.8.3] xref: EC:1.5.8.3 xref: KEGG_REACTION:R00611 xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-6797913 "SARDH:FAD oxidatively demethylates SARC to Gly" xref: RHEA:19793 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0008481 name: sphinganine kinase activity namespace: molecular_function alt_id: GO:0001728 def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase activity" RELATED [] xref: EC:2.7.1.91 xref: MetaCyc:SPHINGANINE-KINASE-RXN xref: Reactome:R-HSA-428214 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP" xref: RHEA:15465 is_a: GO:0001727 ! lipid kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008482 name: sulfite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate." [EC:1.8.3.1, RHEA:24600] synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] synonym: "sulphite oxidase activity" EXACT [] xref: EC:1.8.3.1 xref: KEGG_REACTION:R00533 xref: MetaCyc:PWY-5326 xref: MetaCyc:SULFITE-OXIDASE-RXN xref: Reactome:R-HSA-1614544 "Sulfite is oxidized to sulfate" xref: RHEA:24600 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0008483 name: transaminase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine" is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0008484 name: sulfuric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] synonym: "sulfatase activity" EXACT [] synonym: "sulphuric ester hydrolase activity" EXACT [] xref: EC:3.1.6 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008486 name: diphosphoinositol-polyphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52] synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52] synonym: "DIPP activity" EXACT [EC:3.6.1.52] xref: EC:3.6.1.52 xref: KEGG_REACTION:R05777 xref: MetaCyc:3.6.1.52-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008487 name: obsolete prenyl-dependent CAAX protease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "prenyl-dependent CAAX protease activity" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008488 name: gamma-glutamyl carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194] xref: EC:4.1.1.90 xref: Reactome:R-HSA-159752 "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)" xref: Reactome:R-HSA-159761 "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)" xref: Reactome:R-HSA-159795 "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)" xref: Reactome:R-HSA-159803 "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)" xref: Reactome:R-HSA-159819 "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)" xref: Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)" xref: Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)" xref: Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)" xref: Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)" xref: RHEA:45140 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008489 name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base." [MetaCyc:RXN-10764, PMID:9593693] synonym: "LacCer synthase activity" EXACT [] synonym: "lactosylceramide synthase activity" EXACT [] synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] xref: MetaCyc:RXN-10764 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008490 name: arsenite secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0008491 def: "Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl] synonym: "arsenite porter activity" RELATED [] is_a: GO:0015105 ! arsenite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0008492 name: obsolete cAMP generating peptide activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product. synonym: "cAMP generating peptide activity" EXACT [] synonym: "cyclic AMP generating peptide activity" EXACT [] is_obsolete: true consider: GO:0004016 consider: GO:0005179 consider: GO:0046058 [Term] id: GO:0008493 name: tetracycline transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators] synonym: "tetracyclin transporter activity" EXACT [] synonym: "tetracycline transporter activity" RELATED [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity relationship: part_of GO:0015904 ! tetracycline transmembrane transport [Term] id: GO:0008494 name: translation activator activity namespace: molecular_function def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] is_a: GO:0090079 ! translation regulator activity, nucleic acid binding relationship: part_of GO:0045727 ! positive regulation of translation [Term] id: GO:0008495 name: protoheme IX farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [MetaCyc:HEMEOSYN-RXN] synonym: "haem O synthase activity" EXACT [] synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788] synonym: "heme O synthase activity" EXACT [] synonym: "protohaem IX farnesyltransferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:HEMEOSYN-RXN xref: Reactome:R-HSA-2995330 "COX10 transforms heme to heme O" xref: RHEA:28070 is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0008496 name: mannan endo-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans." [EC:3.2.1.101] synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-D-mannosidase activity" EXACT [] synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] xref: EC:3.2.1.101 xref: MetaCyc:3.2.1.101-RXN xref: Reactome:R-HSA-6799581 "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man" is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0008498 name: obsolete phospholipid scrambling namespace: molecular_function def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "phospholipid scrambling" EXACT [] is_obsolete: true replaced_by: GO:0017121 [Term] id: GO:0008499 name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] synonym: "beta-1,3-GalTase activity" BROAD [] synonym: "beta3Gal-Ts activity" BROAD [] synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] xref: Reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein" xref: Reactome:R-HSA-9603989 "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain" is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0008500 name: obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a conglomeration of three terms. synonym: "glycine-, glutamate-, thienylcyclohexylpiperidine binding" EXACT [] is_obsolete: true consider: GO:0016594 consider: GO:0016595 consider: GO:0016596 [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008503 name: benzodiazepine receptor activity namespace: molecular_function def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015201 def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" is_a: GO:0022804 ! active transmembrane transporter activity relationship: part_of GO:0015844 ! monoamine transport [Term] id: GO:0008506 name: sucrose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] synonym: "hydrogen/sucrose transporter activity" BROAD [] synonym: "sucrose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0009669 ! sucrose:cation symporter activity [Term] id: GO:0008507 name: sodium:iodide symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter activity" EXACT [] xref: Reactome:R-HSA-429591 "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol" xref: Reactome:R-HSA-5658195 "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol" is_a: GO:0015111 ! iodide transmembrane transporter activity is_a: GO:0015373 ! anion:sodium symporter activity [Term] id: GO:0008508 name: bile acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter activity" EXACT [] xref: Reactome:R-HSA-194121 "Co-transport (influx) of bile salts and sodium ions by NTCP" xref: Reactome:R-HSA-194187 "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-433089 "SOAT can transport taurolithocholate-3-sulphate" is_a: GO:0015125 ! bile acid transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0008509 name: anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "anion transporter activity" EXACT [] xref: MIPS_funcat:20.01.01.07 xref: Reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface" is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0098656 ! anion transmembrane transport [Term] id: GO:0008510 name: sodium:bicarbonate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] synonym: "sodium/bicarbonate cotransporter activity" BROAD [] synonym: "sodium:bicarbonate cotransporter activity" BROAD [] xref: Reactome:R-HSA-425483 "SLC4A5,7,9 cotransport Na+ with 3HCO3-" xref: Reactome:R-HSA-5656219 "Defective SLC4A4 does not cotransport Na+ with 3HCO3-" xref: Reactome:R-HSA-8878664 "SLC4A4 cotransports Na+ with 3HCO3-" is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0008511 name: sodium:potassium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter activity" EXACT [] xref: Reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol" xref: Reactome:R-HSA-5623588 "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol" is_a: GO:0009674 ! potassium:sodium symporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:0015379 ! potassium:chloride symporter activity [Term] id: GO:0008512 name: sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] synonym: "sulfate/hydrogen symporter activity" EXACT [] synonym: "sulfate:hydrogen symporter activity" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008513 name: secondary active organic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015354 def: "Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators] synonym: "organic cation porter activity" RELATED [] synonym: "polyspecific organic cation transmembrane transporter activity" NARROW [] xref: Reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol" is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" is_a: GO:0008509 ! anion transmembrane transporter activity relationship: part_of GO:0015711 ! organic anion transport [Term] id: GO:0008515 name: sucrose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019188 def: "Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "sucrose permease (PTS) activity" EXACT [] synonym: "sucrose permease activity" RELATED [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015770 ! sucrose transport [Term] id: GO:0008516 name: hexose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] is_a: GO:0015149 ! hexose transmembrane transporter activity is_a: GO:0015292 ! uniporter activity [Term] id: GO:0008517 name: folic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transmembrane transporter activity" EXACT [] synonym: "folate transporter activity" EXACT [] synonym: "folic acid transporter activity" RELATED [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: Reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane" xref: Reactome:R-HSA-200652 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane" xref: Reactome:R-HSA-200680 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane" xref: Reactome:R-HSA-200720 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane" xref: Reactome:R-HSA-200729 "Extracellular folate import across the plasma membrane" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015884 ! folic acid transport [Term] id: GO:0008518 name: folate:anion antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF." [GOC:mtg_transport, PMID:21568705, PMID:24745983, TC:2.A.48] comment: Changed term label see https://github.com/geneontology/go-ontology/issues/15461. synonym: "reduced folate carrier activity" RELATED [] synonym: "reduced folate transmembrane transporter activity" RELATED [] synonym: "reduced folate transporter" RELATED [] xref: TC:2.A.48 is_a: GO:0008517 ! folic acid transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0008519 name: ammonium transmembrane transporter activity namespace: molecular_function alt_id: GO:0051739 def: "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732] synonym: "ammonia transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-444393 "RhCG mediates ammonium influx into kidney collecting duct cells" xref: Reactome:R-HSA-444416 "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)" xref: Reactome:R-HSA-444419 "RhBG mediates ammonium effflux out of kidney collecting duct cells" xref: Reactome:R-HSA-446277 "RhCG mediates ammonium efflux out of kidney collecting duct cells" xref: Reactome:R-HSA-446278 "RhBG mediates ammonium influx into kidney collecting duct cells" xref: Reactome:R-HSA-5623051 "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc)" xref: RHEA:28747 is_a: GO:0008324 ! cation transmembrane transporter activity relationship: part_of GO:0072488 ! ammonium transmembrane transport [Term] id: GO:0008520 name: L-ascorbate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity [Term] id: GO:0008521 name: acetyl-CoA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] synonym: "acetyl-CoA transporter activity" RELATED [] xref: Reactome:R-HSA-5649742 "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen" xref: Reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015876 ! acetyl-CoA transport [Term] id: GO:0008523 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] xref: Reactome:R-HSA-199206 "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol" xref: Reactome:R-HSA-199219 "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol" xref: Reactome:R-HSA-429581 "SLC5A6 transports vitamins from extracellular region to cytosol" is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0008525 name: phosphatidylcholine transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732] synonym: "phosphatidylcholine transmembrane transporter activity" NARROW [GOC:bf, GOC:vw] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008526 name: phosphatidylinositol transfer activity namespace: molecular_function alt_id: GO:0120018 def: "Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane phosphatidylinositol transfer activity" NARROW [] synonym: "intermembrane phosphotidylinositol transfer activity" NARROW [] synonym: "phosphatidylinositol carrier activity" EXACT [] synonym: "phosphatidylinositol transfer activity" EXACT [] synonym: "phosphatidylinositol transporter activity" BROAD [] xref: Reactome:R-HSA-8869241 "PITPNM1,2,3 exchange PI for PA" xref: Reactome:R-HSA-8874470 "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane" is_a: GO:0120014 ! phospholipid transfer activity relationship: has_part GO:0035091 ! phosphatidylinositol binding created_by: kchris creation_date: 2017-03-17T04:22:47Z [Term] id: GO:0008527 name: taste receptor activity namespace: molecular_function def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] synonym: "gustatory receptor" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste [Term] id: GO:0008528 name: G protein-coupled peptide receptor activity namespace: molecular_function def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008529 name: obsolete endogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "endogenous peptide receptor activity" EXACT [] is_obsolete: true consider: GO:0001653 consider: GO:0005622 [Term] id: GO:0008530 name: obsolete exogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "exogenous peptide receptor activity" EXACT [] is_obsolete: true consider: GO:0001653 consider: GO:0005576 [Term] id: GO:0008531 name: riboflavin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14357] synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] synonym: "FK" RELATED [EC:2.7.1.26] synonym: "flavokinase activity" EXACT [EC:2.7.1.26] synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] xref: EC:2.7.1.26 xref: KEGG_REACTION:R00549 xref: MetaCyc:RIBOFLAVINKIN-RXN xref: Reactome:R-HSA-196964 "RFK:Mg2+ phosphorylates RIB" xref: RHEA:14357 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008532 name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "GnTE activity" EXACT [EC:2.4.1.149] synonym: "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] xref: EC:2.4.1.149 xref: MetaCyc:2.4.1.149-RXN xref: Reactome:R-HSA-2025724 "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG" xref: RHEA:14389 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008533 name: obsolete astacin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] comment: This term was made obsolete because it represents a gene product. synonym: "astacin activity" EXACT [] synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] xref: EC:3.4.24.21 xref: MetaCyc:3.4.24.21-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008534 name: oxidized purine nucleobase lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0003907 def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] synonym: "bifunctional DNA glycosylase activity" BROAD [] synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT [] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: MetaCyc:3.2.2.23-RXN xref: Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase" xref: Reactome:R-HSA-110243 "Cleavage of 8-oxoguanine by OGG1 glycosylase" xref: Reactome:R-HSA-110244 "Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity [Term] id: GO:0008535 name: respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] synonym: "cytochrome c oxidase biogenesis" BROAD [] synonym: "cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0008536 name: Ran GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] synonym: "Ran protein binding" EXACT [] synonym: "Ran-binding protein" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0008537 name: proteasome activator complex namespace: cellular_component def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] synonym: "PA28" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0008538 name: obsolete proteasome activator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PA28" NARROW [] synonym: "proteasome activator activity" EXACT [] is_obsolete: true consider: GO:0061133 consider: GO:0061136 [Term] id: GO:0008539 name: obsolete proteasome inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PI-31" NARROW [] synonym: "proteasome inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004866 consider: GO:0061136 [Term] id: GO:0008540 name: proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008541 name: proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008542 name: visual learning namespace: biological_process def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] synonym: "spatial learning" RELATED [] is_a: GO:0007632 ! visual behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0008543 name: fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "FGF receptor signaling pathway" EXACT [] synonym: "FGF receptor signalling pathway" EXACT [] synonym: "FGFR signaling pathway" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.12.03 is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development [Term] id: GO:0008545 name: JUN kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] synonym: "JNKK" EXACT [] xref: Reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7" is_a: GO:0004708 ! MAP kinase kinase activity relationship: part_of GO:0007257 ! activation of JUN kinase activity [Term] id: GO:0008546 name: obsolete microtubule/chromatin interaction namespace: biological_process def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] comment: This term was made obsolete because it represents a molecular function. synonym: "microtubule/chromatin interaction" EXACT [] is_obsolete: true consider: GO:0003677 consider: GO:0003682 consider: GO:0008017 consider: GO:0030674 [Term] id: GO:0008547 name: obsolete protein-synthesizing GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "protein-synthesizing GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0006412 consider: GO:0008135 [Term] id: GO:0008548 name: obsolete signal-recognition-particle GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "signal-recognition-particle GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005786 [Term] id: GO:0008549 name: obsolete dynamin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "dynamin GTPase activity" EXACT [] synonym: "dynamine GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006897 [Term] id: GO:0008550 name: obsolete tubulin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "tubulin GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0007021 [Term] id: GO:0008551 name: cadmium transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function alt_id: GO:0008561 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] synonym: "cadmium exporting ATPase activity" EXACT [] synonym: "cadmium-exporting ATPase activity" EXACT [] synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] xref: EC:3.6.3.3 xref: MetaCyc:3.6.3.3-RXN xref: RHEA:12132 is_a: GO:0015434 ! ATPase-coupled cadmium transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism [Term] id: GO:0008552 name: obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015086 consider: GO:0015087 consider: GO:0015094 consider: GO:0015099 consider: GO:0015662 [Term] id: GO:0008553 name: proton-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function alt_id: GO:0036442 def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:7.1.2.1] synonym: "H(+)-transporting ATPase activity" BROAD [EC:7.1.2.1] synonym: "H+-exporting ATPase activity" EXACT [EC:7.1.2.1] synonym: "H+-transporting ATPase" BROAD [EC:7.1.2.1] synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "hydrogen-exporting ATPase activity" BROAD [] synonym: "hydrogen-exporting ATPase activity, phosphorylative mechanism" RELATED [] synonym: "P-type H(+)-exporting ATPase activity" BROAD [EC:7.1.2.1] synonym: "proton transport ATPase activity" RELATED [EC:7.1.2.1] synonym: "proton-exporting ATPase activity" BROAD [] synonym: "proton-translocating ATPase activity" EXACT [EC:7.1.2.1] synonym: "proton-transporting ATPase activity" EXACT [GOC:bf] xref: EC:7.1.2.1 xref: MetaCyc:3.6.3.6-RXN xref: RHEA:20852 is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity created_by: rfoulger creation_date: 2013-09-30T16:56:16Z [Term] id: GO:0008554 name: sodium transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:7.2.2.3] synonym: "ATP phosphohydrolase (Na+-exporting)" RELATED [EC:7.2.2.3] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "Na(+)-exporting ATPase activity" RELATED [EC:7.2.2.3] synonym: "Na(+)-transporting ATPase activity" BROAD [EC:7.2.2.3] synonym: "Na+-exporting ATPase activity" RELATED [EC:7.2.2.3] synonym: "Na+-transporting ATPase activity" EXACT [EC:7.2.2.3] synonym: "sodium exporting ATPase activity, phosphorylative mechanism" RELATED [] synonym: "sodium transport ATPase activity" RELATED [EC:7.2.2.3] synonym: "sodium-exporting ATPase activity" RELATED [EC:7.2.2.3] synonym: "sodium-exporting ATPase activity, phosphorylative mechanism" RELATED [] synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:7.2.2.3] xref: EC:7.2.2.3 xref: MetaCyc:3.6.3.7-RXN xref: RHEA:14633 is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0008555 name: ATPase-coupled chloride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] synonym: "ATP-dependent chloride transmembrane transporter activity" EXACT [] synonym: "chloride ABC transporter" NARROW [] synonym: "chloride transporting ATPase activity" EXACT [] synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-transporting ATPase activity" EXACT [] synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: MetaCyc:3.6.3.11-RXN xref: RHEA:24128 is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0008556 name: potassium transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function alt_id: GO:0015618 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:7.2.2.6] synonym: "ATP phosphohydrolase (K+-importing)" RELATED [EC:7.2.2.6] synonym: "ATP-dependent potassium transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled potassium transmembrane transporter activity" RELATED [] synonym: "K(+)-importing ATPase activity" NARROW [EC:7.2.2.6] synonym: "K(+)-transporting ATPase activity" EXACT [EC:7.2.2.6] synonym: "K+-importing ATPase activity" RELATED [EC:7.2.2.6] synonym: "K+-transporting ATPase activity" EXACT [] synonym: "potassium ABC transporter" NARROW [] synonym: "potassium transporting ATPase activity" EXACT [] synonym: "potassium-importing ATPase activity" NARROW [EC:7.2.2.6] synonym: "potassium-transporting ATPase activity" EXACT [] synonym: "potassium-uptake-ATPase activity" EXACT [] xref: EC:7.2.2.6 xref: RHEA:16777 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0008558 name: ATPase-coupled guanine transmembrane transporter activity namespace: molecular_function def: "Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:7.6.2.6] synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:7.6.2.6] synonym: "ATP-dependent guanine transmembrane transporter activity" EXACT [] synonym: "guanine ABC transporter" NARROW [] synonym: "guanine-transporting ATPase activity" EXACT [EC:7.6.2.6] xref: EC:7.6.2.6 xref: MetaCyc:3.6.3.37-RXN xref: RHEA:20832 is_a: GO:0015208 ! guanine transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0008559 name: ATPase-coupled xenobiotic transmembrane transporter activity namespace: molecular_function alt_id: GO:0005226 alt_id: GO:0008560 def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2] synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:7.6.2.2] synonym: "ATP-dependent xenobiotic transmembrane transporter activity" EXACT [] synonym: "MDR protein" RELATED [EC:7.6.2.2] synonym: "multidrug resistance exporter" RELATED [] synonym: "multidrug-resistance protein" RELATED [] synonym: "P-glycoprotein" RELATED [EC:7.6.2.2] synonym: "PDR protein" RELATED [EC:7.6.2.2] synonym: "pleiotropic-drug-resistance protein" RELATED [EC:7.6.2.2] synonym: "xenobiotic ABC transporter" NARROW [] synonym: "xenobiotic transmembrane transporting ATPase activity" EXACT [] xref: EC:7.6.2.2 xref: MetaCyc:3.6.3.44-RXN xref: Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region" xref: Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" xref: Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0008563 name: obsolete alpha-factor sex pheromone exporter namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. synonym: "alpha-factor sex pheromone exporter" EXACT [] synonym: "alpha-factor-transporting ATPase" RELATED [] is_obsolete: true [Term] id: GO:0008564 name: protein-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins." [EC:7.4.2.8] synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:7.4.2.8] synonym: "protein-secreting ATPase activity" EXACT [] xref: EC:7.4.2.8 xref: MetaCyc:3.6.3.50-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0008565 name: obsolete protein transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] comment: This term was obsoleted because is has been inconsistently used. synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] xref: MIPS_funcat:20.01.10 xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" is_obsolete: true [Term] id: GO:0008566 name: mitochondrial protein-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:7.4.2.3] comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:7.4.2.3] xref: EC:7.4.2.3 xref: MetaCyc:3.6.3.51-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0008567 name: obsolete dynein ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "dynein ATPase activity" EXACT [] is_obsolete: true consider: GO:0003777 consider: GO:0007018 [Term] id: GO:0008568 name: microtubule-severing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:5.6.1.1, PMID:10910766] comment: See also the cellular component term 'katanin complex ; GO:0008352'. synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [] synonym: "katanin activity" NARROW [] {comment="EC:5.6.1.1"} xref: EC:5.6.1.1 xref: MetaCyc:3.6.4.3-RXN is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0051013 ! microtubule severing [Term] id: GO:0008569 name: ATP-dependent microtubule motor activity, minus-end-directed namespace: molecular_function def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:5.6.1.4, GOC:mah, GOC:vw] synonym: "ATP-dependent minus-end-directed microtubule motor activity" EXACT [] synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [] synonym: "minus-end-directed ATP-dependent microtubule motor activity" EXACT [] synonym: "minus-end-directed kinesin ATPase activity" EXACT [] synonym: "minus-end-directed microtubule motor activity" BROAD [] xref: EC:5.6.1.4 xref: MetaCyc:3.6.4.5-RXN is_a: GO:1990939 ! ATP-dependent microtubule motor activity [Term] id: GO:0008570 name: obsolete myosin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "myosin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0000146 consider: GO:0030048 [Term] id: GO:0008571 name: obsolete non-chaperonin molecular chaperone ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] comment: This term was made obsolete because it represents a class of gene products. synonym: "non-chaperonin molecular chaperone ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0008572 name: obsolete nucleoplasmin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "nucleoplasmin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006333 [Term] id: GO:0008573 name: obsolete peroxisome-assembly ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] comment: This term was made obsolete because it incorporates process information. synonym: "peroxisome-assembly ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0007031 [Term] id: GO:0008574 name: ATP-dependent microtubule motor activity, plus-end-directed namespace: molecular_function def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP." [EC:5.6.1.3, GOC:vw] synonym: "ATP-dependent plus-end-directed microtubule motor activity" EXACT [] synonym: "kinesin activity" RELATED [] {comment="EC:5.6.1.3"} synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [] synonym: "plus-end-directed ATP-dependent microtubule motor activity" EXACT [] synonym: "plus-end-directed kinesin ATPase activity" EXACT [] synonym: "plus-end-directed microtubule motor activity" BROAD [] xref: EC:5.6.1.3 xref: MetaCyc:3.6.4.4-RXN is_a: GO:1990939 ! ATP-dependent microtubule motor activity [Term] id: GO:0008575 name: obsolete proteasome ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] comment: This term was made obsolete because it mentions a component term in the term text string. synonym: "proteasome ATPase activity" EXACT [] is_obsolete: true consider: GO:0016887 [Term] id: GO:0008576 name: obsolete vesicle-fusing ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] comment: This term was made obsolete because it incorporates process information. synonym: "vesicle-fusing ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0016192 consider: GO:0061025 [Term] id: GO:0008579 name: JUN kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity [Term] id: GO:0008580 name: obsolete cytoskeletal regulator activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. synonym: "cytoskeletal regulator activity" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0008581 name: obsolete ubiquitin-specific protease 5 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] comment: This term was made obsolete because it represents a gene product. synonym: "ubiquitin isopeptidase T activity" EXACT [] synonym: "ubiquitin-specific protease 5 activity" EXACT [] is_obsolete: true replaced_by: GO:0004843 [Term] id: GO:0008582 name: regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051124 ! synaptic growth at neuromuscular junction relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0008583 name: mystery cell differentiation namespace: biological_process def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0008584 name: male gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "testicular development" EXACT [GOC:sl] synonym: "testis development" EXACT [GOC:sl] xref: MIPS_funcat:47.03.15.07 is_a: GO:0008406 ! gonad development relationship: part_of GO:0046546 ! development of primary male sexual characteristics [Term] id: GO:0008585 name: female gonad development namespace: biological_process alt_id: GO:0061039 def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] xref: MIPS_funcat:47.03.15.01 is_a: GO:0008406 ! gonad development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0008586 name: imaginal disc-derived wing vein morphogenesis namespace: biological_process def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] synonym: "wing vein morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008587 name: imaginal disc-derived wing margin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. synonym: "wing margin morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008589 name: regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0007226 alt_id: GO:0043109 def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of smoothened activity" RELATED [] synonym: "regulation of smoothened by patched" RELATED [] synonym: "regulation of smoothened receptor activity by patched" RELATED [] synonym: "regulation of smoothened signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007224 ! smoothened signaling pathway relationship: regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0008591 name: regulation of Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of frizzled-2 signaling pathway" EXACT [] synonym: "regulation of frizzled-2 signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway relationship: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway [Term] id: GO:0008592 name: regulation of Toll signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "regulation of Tl signaling pathway" EXACT [] synonym: "regulation of Tl signalling pathway" EXACT [] synonym: "regulation of Toll signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008063 ! Toll signaling pathway relationship: regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0008593 name: regulation of Notch signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "regulation of N signaling pathway" EXACT [] synonym: "regulation of N signalling pathway" EXACT [] synonym: "regulation of Notch signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007219 ! Notch signaling pathway relationship: regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0008595 name: anterior/posterior axis specification, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0007351 ! tripartite regional subdivision [Term] id: GO:0008597 name: calcium-dependent protein serine/threonine phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] xref: Reactome:R-HSA-139906 "Activation of BAD by calcineurin" is_a: GO:0019888 ! protein phosphatase regulator activity relationship: regulates GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity [Term] id: GO:0008603 name: cAMP-dependent protein kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] is_a: GO:0019887 ! protein kinase regulator activity relationship: part_of GO:2000479 ! regulation of cAMP-dependent protein kinase activity [Term] id: GO:0008605 name: obsolete protein kinase CK2 regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "casein kinase II, regulator" EXACT [] synonym: "protein kinase CK2 regulator activity" EXACT [] synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] is_obsolete: true replaced_by: GO:0019887 [Term] id: GO:0008607 name: phosphorylase kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1 is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0008608 name: attachment of spindle microtubules to kinetochore namespace: biological_process alt_id: GO:0051313 def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation). synonym: "amphotelic attachment" RELATED [] synonym: "attachment of spindle microtubules to chromosome" EXACT [] synonym: "bipolar attachment" RELATED [] synonym: "kinetochore microtubule interaction" BROAD [] synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore-microtubule interaction" BROAD [] synonym: "microtubule anchoring at kinetochore" EXACT [] synonym: "microtubule and chromosome interaction" BROAD [] synonym: "microtubule and kinetochore interaction" RELATED [] synonym: "microtubule capture" NARROW [] synonym: "spindle chromosome attachment" EXACT [] synonym: "spindle kinetochore attachment" EXACT [] synonym: "spindle-chromosome interaction" BROAD [] is_a: GO:0022402 ! cell cycle process relationship: has_part GO:0008017 ! microtubule binding relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0008609 name: alkylglycerone-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] synonym: "DHAP-AT" RELATED [EC:2.5.1.26] synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] xref: EC:2.5.1.26 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN xref: Reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] xref: MIPS_funcat:01.06.01 is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0008611 name: ether lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] synonym: "ether lipid anabolism" EXACT [] synonym: "ether lipid biosynthesis" EXACT [] synonym: "ether lipid formation" EXACT [] synonym: "ether lipid synthesis" EXACT [] synonym: "plasmalogen biosynthetic process" NARROW [] is_a: GO:0046485 ! ether lipid metabolic process is_a: GO:0046504 ! glycerol ether biosynthetic process is_a: GO:0097384 ! cellular lipid biosynthetic process [Term] id: GO:0008612 name: peptidyl-lysine modification to peptidyl-hypusine namespace: biological_process alt_id: GO:0046515 def: "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] synonym: "hypusine anabolism" EXACT [] synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] synonym: "hypusine biosynthesis" EXACT [] synonym: "hypusine biosynthetic process" EXACT [] synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] synonym: "hypusine formation" EXACT [] synonym: "hypusine formation from peptidyl-lysine" EXACT [] synonym: "hypusine synthesis" EXACT [] synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] synonym: "hypusinylation" EXACT [] synonym: "protein hypusination" EXACT [] xref: RESID:AA0116 is_a: GO:0009058 ! biosynthetic process is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0008613 name: diuretic hormone activity namespace: molecular_function def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008614 name: pyridoxine metabolic process namespace: biological_process alt_id: GO:0006773 def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:curators] synonym: "pyridoxine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0008615 name: pyridoxine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] synonym: "pyridoxine anabolism" EXACT [] synonym: "pyridoxine biosynthesis" EXACT [] synonym: "pyridoxine formation" EXACT [] synonym: "pyridoxine synthesis" EXACT [] is_a: GO:0008614 ! pyridoxine metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0008616 name: queuosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732] synonym: "queuosine anabolism" EXACT [] synonym: "queuosine biosynthesis" EXACT [] synonym: "queuosine formation" EXACT [] synonym: "queuosine synthesis" EXACT [] is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046116 ! queuosine metabolic process [Term] id: GO:0008617 name: guanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732] synonym: "guanosine metabolism" EXACT [] is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0008618 name: 7-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] synonym: "7-methylguanosine metabolism" EXACT [] is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0008619 name: obsolete RHEB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] comment: This term was made obsolete because it represents a gene product. synonym: "RHEB small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 consider: GO:0051726 [Term] id: GO:0008622 name: epsilon DNA polymerase complex namespace: cellular_component def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420] is_a: GO:0042575 ! DNA polymerase complex relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0008623 name: CHRAC namespace: cellular_component alt_id: GO:0016588 def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192] synonym: "chromatin accessibility complex" EXACT [] synonym: "ISW2 complex" NARROW [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0008625 name: extrinsic apoptotic signaling pathway via death domain receptors namespace: biological_process def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013. synonym: "death receptor-mediated apoptosis" NARROW [] synonym: "induction of apoptosis via death domain receptors" RELATED [] synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah] is_a: GO:0097191 ! extrinsic apoptotic signaling pathway [Term] id: GO:0008626 name: granzyme-mediated apoptotic signaling pathway namespace: biological_process def: "A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [GOC:mtg_apoptosis, PMID:17158907] synonym: "apoptotic signaling pathway in response to granzyme" RELATED [] synonym: "induction of apoptosis by granzyme" RELATED [] is_a: GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0008627 name: intrinsic apoptotic signaling pathway in response to osmotic stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738] synonym: "induction of apoptosis by ionic changes" RELATED [] is_a: GO:0071470 ! cellular response to osmotic stress is_a: GO:0097193 ! intrinsic apoptotic signaling pathway [Term] id: GO:0008628 name: hormone-mediated apoptotic signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:mtg_apoptosis] comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use. synonym: "apoptotic signaling pathway in response to hormone" RELATED [] synonym: "induction of apoptosis by hormones" RELATED [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0008630 name: intrinsic apoptotic signaling pathway in response to DNA damage namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0097193 ! intrinsic apoptotic signaling pathway [Term] id: GO:0008631 name: intrinsic apoptotic signaling pathway in response to oxidative stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] synonym: "induction of apoptosis by oxidative stress" RELATED [] synonym: "oxidative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] is_a: GO:0097193 ! intrinsic apoptotic signaling pathway relationship: part_of GO:0036473 ! cell death in response to oxidative stress [Term] id: GO:0008633 name: obsolete activation of pro-apoptotic gene products namespace: biological_process def: "OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition). synonym: "activation of pro-apoptotic gene products" EXACT [] synonym: "induction of pro-apoptotic gene products" RELATED [] xref: MIPS_funcat:40.10.02.02.04 is_obsolete: true [Term] id: GO:0008634 name: obsolete negative regulation of survival gene product expression namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. synonym: "down regulation of survival gene product activity" BROAD [] synonym: "down-regulation of survival gene product activity" BROAD [] synonym: "downregulation of survival gene product activity" BROAD [] synonym: "inhibition of survival gene product activity" NARROW [] synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "negative regulation of survival gene product expression" EXACT [] synonym: "negative regulation of survival gene products" BROAD [] xref: MIPS_funcat:40.10.02.02.05 is_obsolete: true [Term] id: GO:0008635 name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase] synonym: "activation of caspase activity by cytochrome c" NARROW [] synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb] is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0008636 name: obsolete activation of caspase activity by protein phosphorylation namespace: biological_process def: "OBSOLETE. Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage). synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "activation of caspase activity by protein phosphorylation" EXACT [] synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0008637 name: apoptotic mitochondrial changes namespace: biological_process def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it. xref: MIPS_funcat:40.10.02.02.01 is_a: GO:0007005 ! mitochondrion organization relationship: part_of GO:0006915 ! apoptotic process [Term] id: GO:0008638 name: obsolete protein tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] comment: This term was made obsolete because it represents a biological process and a molecular function. synonym: "protein tagging activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0006464 consider: GO:0031386 [Term] id: GO:0008641 name: ubiquitin-like modifier activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] comment: Discussion of class label in this ticket: https://github.com/geneontology/go-ontology/issues/14208 subset: goslim_pir synonym: "small protein activating enzyme activity" NARROW [] is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "sugar transport" NARROW [] xref: MIPS_funcat:20.01.03 is_a: GO:0071702 ! organic substance transport [Term] id: GO:0008645 name: hexose transmembrane transport namespace: biological_process alt_id: GO:0008646 alt_id: GO:0008647 alt_id: GO:0035428 def: "The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hexose membrane transport" RELATED [] synonym: "hexose transport" RELATED [] synonym: "high-affinity hexose transport" NARROW [] synonym: "low-affinity hexose transport" NARROW [] is_a: GO:0015749 ! monosaccharide transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:27:23Z [Term] id: GO:0008648 name: obsolete tachykinin namespace: molecular_function def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "tachykinin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045987 consider: GO:0046878 consider: GO:0097755 [Term] id: GO:0008649 name: rRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0140102 ! catalytic activity, acting on a rRNA relationship: part_of GO:0031167 ! rRNA methylation [Term] id: GO:0008650 name: rRNA (uridine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] xref: Reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine" is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity [Term] id: GO:0008651 name: obsolete actin polymerizing activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin polymerizing activity" EXACT [] is_obsolete: true consider: GO:0030041 consider: GO:0042802 [Term] id: GO:0008652 name: cellular amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid biosynthetic process" EXACT [] synonym: "cellular amino acid anabolism" EXACT [] synonym: "cellular amino acid biosynthesis" EXACT [] synonym: "cellular amino acid formation" EXACT [] synonym: "cellular amino acid synthesis" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0008653 name: lipopolysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732] synonym: "lipopolysaccharide metabolism" EXACT [] synonym: "LPS metabolic process" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:1903509 ! liposaccharide metabolic process [Term] id: GO:0008654 name: phospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid anabolism" EXACT [] synonym: "phospholipid biosynthesis" EXACT [] synonym: "phospholipid formation" EXACT [] synonym: "phospholipid synthesis" EXACT [] xref: MetaCyc:LIPASYN-PWY xref: MetaCyc:PHOSLIPSYN-PWY xref: MetaCyc:PHOSLIPSYN2-PWY xref: MIPS_funcat:01.06.01.01 is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0008655 name: pyrimidine-containing compound salvage namespace: biological_process def: "Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl] subset: goslim_pir synonym: "pyrimidine salvage" RELATED [] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0008656 name: cysteine-type endopeptidase activator activity involved in apoptotic process namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis] comment: Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases. synonym: "caspase activator activity" BROAD [] xref: Reactome:R-HSA-205117 "p75NTR:NADE promotes caspase2/3 activation" xref: Reactome:R-HSA-449073 "Caspase-3 cleaves pro-interleukin-16" is_a: GO:0016505 ! peptidase activator activity involved in apoptotic process is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process relationship: part_of GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0008657 name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0042030 ! ATPase inhibitor activity is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity relationship: negatively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity relationship: part_of GO:2000372 ! negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity [Term] id: GO:0008658 name: penicillin binding namespace: molecular_function def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: goslim_metagenomics is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0008659 name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59, GOC:ai] synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.59 xref: RHEA:13097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008660 name: 1-aminocyclopropane-1-carboxylate deaminase activity namespace: molecular_function alt_id: GO:0018806 def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+)." [EC:3.5.99.7, RHEA:16933] comment: Note that this function was formerly EC:4.1.99.4. synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: KEGG_REACTION:R00997 xref: MetaCyc:4.1.99.4-RXN xref: RHEA:16933 xref: UM-BBD_reactionID:r0357 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008661 name: 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)." [EC:2.2.1.7, RHEA:12605] synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] synonym: "DOXP synthase activity" EXACT [] synonym: "DXP-synthase activity" EXACT [] synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] xref: EC:2.2.1.7 xref: KEGG_REACTION:R05636 xref: MetaCyc:DXS-RXN xref: RHEA:12605 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0008662 name: 1-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] xref: EC:2.7.1.56 xref: MetaCyc:1PFRUCTPHOSN-RXN xref: RHEA:14213 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0008663 name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: MetaCyc:CYCPHOSDIESTER-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0008664 name: 2'-5'-RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112] synonym: "2'-5' RNA ligase activity" EXACT [] is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0008666 name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17325] synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346] xref: EC:2.3.1.117 xref: KEGG_REACTION:R04365 xref: MetaCyc:TETHYDPICSUCC-RXN xref: RHEA:17325 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008667 name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH." [EC:1.3.1.28, RHEA:23824] synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] xref: EC:1.3.1.28 xref: KEGG_REACTION:R01505 xref: MetaCyc:DHBDEHYD-RXN xref: RHEA:23824 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008668 name: (2,3-dihydroxybenzoyl)adenylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate." [EC:2.7.7.58, RHEA:20229] synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] xref: EC:2.7.7.58 xref: KEGG_REACTION:R01504 xref: MetaCyc:DHBAMPLIG-RXN xref: RHEA:20229 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008670 name: 2,4-dienoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: MetaCyc:DIENOYLCOAREDUCT-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008671 name: 2-dehydro-3-deoxygalactonokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+)." [EC:2.7.1.58, RHEA:16525] synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] xref: EC:2.7.1.58 xref: KEGG_REACTION:R03387 xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN xref: RHEA:16525 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008672 name: 2-dehydro-3-deoxyglucarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] xref: EC:4.1.2.20 xref: MetaCyc:KDGALDOL-RXN xref: RHEA:10268 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008673 name: 2-dehydro-3-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.45, RHEA:14797] synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] xref: EC:2.7.1.45 xref: KEGG_REACTION:R01541 xref: MetaCyc:DEOXYGLUCONOKIN-RXN xref: RHEA:14797 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008674 name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24464] synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] xref: EC:4.1.2.21 xref: KEGG_REACTION:R01064 xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN xref: RHEA:24464 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008675 name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] xref: EC:4.1.2.14 xref: MetaCyc:KDPGALDOL-RXN xref: RHEA:17089 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008676 name: 3-deoxy-8-phosphooctulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate." [EC:2.5.1.55, RHEA:14053] comment: Note that this function was formerly EC:4.1.2.16. synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] xref: EC:2.5.1.55 xref: KEGG_REACTION:R03254 xref: MetaCyc:KDO-8PSYNTH-RXN xref: RHEA:14053 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008677 name: 2-dehydropantoate 2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [EC:1.1.1.169, RHEA:16233] synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] xref: EC:1.1.1.169 xref: KEGG_REACTION:R02472 xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN xref: RHEA:16233 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008678 name: 2-deoxy-D-gluconate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] xref: EC:1.1.1.125 xref: MetaCyc:KDUD-RXN xref: RHEA:12160 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008679 name: 2-hydroxy-3-oxopropionate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] synonym: "tartronate semialdehyde reductase (NADPH) activity" EXACT [EC:1.1.1.60] xref: EC:1.1.1.60 xref: MetaCyc:TSA-REDUCT-RXN xref: RHEA:18841 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008681 name: 2-octaprenyl-6-methoxyphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN] xref: EC:1.14.14 xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN xref: RHEA:29407 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008682 name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] synonym: "demethoxy-ubiquinone hydroxylase" RELATED [GOC:vw] synonym: "demethoxyubiquinone monooxygenase" RELATED [GOC:vw] xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008683 name: 2-oxoglutarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde." [EC:4.1.1.71, RHEA:10524] synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] xref: EC:4.1.1.71 xref: KEGG_REACTION:R00272 xref: MetaCyc:RXN-7774 xref: RHEA:10524 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008684 name: 2-oxopent-4-enoate hydratase activity namespace: molecular_function alt_id: GO:0018821 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] synonym: "OEH activity" EXACT [EC:4.2.1.80] xref: EC:4.2.1.80 xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN xref: RHEA:22580 xref: UM-BBD_enzymeID:e0078 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008685 name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23864] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] synonym: "MECP synthase activity" EXACT [] xref: EC:4.6.1.12 xref: KEGG_REACTION:R05637 xref: MetaCyc:RXN0-302 xref: RHEA:23864 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0008686 name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)." [EC:4.1.99.12, RHEA:18457] xref: EC:4.1.99.12 xref: KEGG_REACTION:R07281 xref: MetaCyc:DIOHBUTANONEPSYN-RXN xref: RHEA:18457 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0008687 name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+)." [EC:1.13.11.15, RHEA:15633] synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] xref: EC:1.13.11.15 xref: KEGG_REACTION:R03303 xref: MetaCyc:1.13.11.15-RXN xref: RHEA:15633 xref: UM-BBD_reactionID:r0364 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008688 name: 3-(3-hydroxyphenyl)propionate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [MetaCyc:MHPHYDROXY-RXN] xref: EC:1.14.13 xref: KEGG_REACTION:R06786 xref: MetaCyc:MHPHYDROXY-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008689 name: 3-demethylubiquinone-9 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] xref: EC:2.1.1.64 xref: MetaCyc:DHHB-METHYLTRANSFER-RXN xref: RHEA:17049 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity [Term] id: GO:0008690 name: 3-deoxy-manno-octulosonate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] xref: EC:2.7.7.38 xref: MetaCyc:CPM-KDOSYNTH-RXN xref: RHEA:23448 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008691 name: 3-hydroxybutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "BHBD activity" EXACT [EC:1.1.1.157] synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] xref: EC:1.1.1.157 xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN xref: RHEA:16197 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008692 name: 3-hydroxybutyryl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] xref: EC:5.1.2.3 xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN xref: RHEA:21760 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008693 name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59] synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "FabA" RELATED [] synonym: "HDDase activity" EXACT [EC:4.2.1.59] xref: EC:4.2.1.59 is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0008694 name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity namespace: molecular_function alt_id: GO:0019167 def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "PPHB decarboxylase activity" EXACT [] synonym: "UbiD" RELATED [] synonym: "UbiX" RELATED [] xref: EC:4.1.1.98 xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN xref: RHEA:27778 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008695 name: 3-phenylpropionate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: MetaCyc:HCAMULTI-RXN xref: RHEA:20357 xref: UM-BBD_enzymeID:e0307 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008696 name: 4-amino-4-deoxychorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate." [EC:4.1.3.38, RHEA:16201] comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] synonym: "aminodeoxychorismate lyase activity" EXACT [] synonym: "enzyme X activity" RELATED [EC:4.1.3.38] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase" RELATED [] xref: EC:4.1.3.38 xref: KEGG_REACTION:R05553 xref: MetaCyc:ADCLY-RXN xref: RHEA:16201 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008697 name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23896] synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] xref: EC:5.3.1.17 xref: KEGG_REACTION:R04383 xref: MetaCyc:5.3.1.17-RXN xref: RHEA:23896 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008700 name: 4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] xref: EC:4.1.3.16 xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN xref: Reactome:R-HSA-6784423 "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate" xref: RHEA:18169 is_a: GO:0016832 ! aldehyde-lyase activity is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008701 name: 4-hydroxy-2-oxovalerate aldolase activity namespace: molecular_function alt_id: GO:0018804 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22624] synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "DmpG" RELATED [EC:4.1.3.39] synonym: "HOA" RELATED [EC:4.1.3.39] xref: EC:4.1.3.39 xref: KEGG_REACTION:R00750 xref: MetaCyc:MHPELY-RXN xref: RHEA:22624 xref: UM-BBD_enzymeID:e0077 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008703 name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH." [EC:1.1.1.193, RHEA:17845] synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] xref: EC:1.1.1.193 xref: KEGG_REACTION:R03458 xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN xref: RHEA:17845 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008704 name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity namespace: molecular_function alt_id: GO:0018843 def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] synonym: "HHDD isomerase activity" EXACT [] synonym: "hpaG-1" RELATED [] synonym: "hpaG1" RELATED [] xref: EC:5.3.3.10 xref: MetaCyc:5.3.3.10-RXN xref: RHEA:18813 xref: UM-BBD_reactionID:r0366 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008705 name: methionine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11172] synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] synonym: "MetH" RELATED [EC:2.1.1.13] synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] xref: EC:2.1.1.13 xref: KEGG_REACTION:R00946 xref: MetaCyc:HOMOCYSMETB12-RXN xref: Reactome:R-HSA-174374 "MTR transfers CH3 from MeCbl to HCYS" xref: Reactome:R-HSA-3149539 "MTR transfers CH3 group from MTHF to cob(I)alamin" xref: RHEA:11172 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity relationship: part_of GO:0009086 ! methionine biosynthetic process [Term] id: GO:0008706 name: 6-phospho-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] xref: EC:3.2.1.86 xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN xref: RHEA:10772 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0008707 name: 4-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] synonym: "6-phytase activity" EXACT [] synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] synonym: "phytase activity" BROAD [EC:3.1.3.26] synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] xref: EC:3.1.3.26 xref: MetaCyc:6-PHYT-RXN xref: RHEA:20960 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008709 name: cholate 7-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.159, RHEA:19409] synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159] xref: EC:1.1.1.159 xref: KEGG_REACTION:R02792 xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN xref: RHEA:19409 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008710 name: 8-amino-7-oxononanoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA." [EC:2.3.1.47, RHEA:20712] synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "AONS activity" EXACT [EC:2.3.1.47] xref: EC:2.3.1.47 xref: KEGG_REACTION:R03210 xref: MetaCyc:7KAPSYN-RXN xref: RHEA:20712 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008711 name: obsolete ADP-L-glycero-D-manno-heptose synthase activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:curators] comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). synonym: "ADP-L-glycero-D-manno-heptose synthase activity" EXACT [] is_obsolete: true consider: GO:0033785 consider: GO:0033786 [Term] id: GO:0008712 name: ADP-glyceromanno-heptose 6-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17577] synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] xref: EC:5.1.3.20 xref: KEGG_REACTION:R05176 xref: MetaCyc:5.1.3.20-RXN xref: RHEA:17577 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008713 name: ADP-heptose-lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061] synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5061 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0008714 name: AMP nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20129] synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] xref: EC:3.2.2.4 xref: KEGG_REACTION:R00182 xref: MetaCyc:AMP-NUCLEOSID-RXN xref: RHEA:20129 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008715 name: CDP-diacylglycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+)." [EC:3.6.1.26, RHEA:15221] synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] xref: EC:3.6.1.26 xref: KEGG_REACTION:R01797 xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN xref: RHEA:15221 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008716 name: D-alanine-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.4, RHEA:11224] synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] xref: EC:6.3.2.4 xref: KEGG_REACTION:R01150 xref: MetaCyc:DALADALALIG-RXN xref: RHEA:11224 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008717 name: obsolete D-alanyl-D-alanine endopeptidase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT [] synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0008718 name: D-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] xref: EC:1.4.99.1 xref: MetaCyc:DAADEHYDROG-RXN xref: RHEA:18125 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0008719 name: dihydroneopterin triphosphate 2'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] xref: EC:5.1.99.7 xref: MetaCyc:H2NTPEPIM-RXN xref: RHEA:28346 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0008720 name: D-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." [EC:1.1.1.28, RHEA:16369] synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] xref: EC:1.1.1.28 xref: KEGG_REACTION:R00704 xref: MetaCyc:DLACTDEHYDROGNAD-RXN xref: RHEA:16369 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008721 name: D-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] comment: Note that this function was formerly EC:4.3.1.14. synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: MetaCyc:DSERDEAM-RXN xref: Reactome:R-HSA-9014741 "SRR dimer:PXLP deaminates D-Ser" xref: Reactome:R-HSA-9034539 "SRR dimer:PXLP deaminates L-Ser" xref: RHEA:13977 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008724 name: obsolete DNA topoisomerase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] comment: This term was made obsolete because it represents a gene product. synonym: "DNA topoisomerase IV activity" EXACT [] is_obsolete: true replaced_by: GO:0003918 [Term] id: GO:0008725 name: DNA-3-methyladenine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosylase I activity" EXACT [] xref: EC:3.2.2.20 xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.20-RXN xref: MetaCyc:3.2.2.21-RXN is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity [Term] id: GO:0008726 name: alkanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280] synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] synonym: "alkanesulphonate monooxygenase activity" EXACT [] synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: MetaCyc:RXN0-280 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008727 name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN] xref: MetaCyc:GDPMANMANHYDRO-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0008728 name: GTP diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "GPSI" RELATED [EC:2.7.6.5] synonym: "GPSII" RELATED [EC:2.7.6.5] synonym: "GTP pyrophosphokinase activity" EXACT [] synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] synonym: "stringent factor activity" RELATED [EC:2.7.6.5] xref: EC:2.7.6.5 xref: MetaCyc:GTPPYPHOSKIN-RXN xref: RHEA:22088 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0008730 name: L(+)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.32, RHEA:15413] synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] xref: EC:4.2.1.32 xref: KEGG_REACTION:R00339 xref: MetaCyc:LTARTDEHYDRA-RXN xref: RHEA:15413 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008732 name: L-allo-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2 xref: MetaCyc:LTAA-RXN is_a: GO:0004793 ! threonine aldolase activity [Term] id: GO:0008733 name: L-arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14821] synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] xref: EC:5.3.1.4 xref: KEGG_REACTION:R01761 xref: MetaCyc:ARABISOM-RXN xref: RHEA:14821 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008734 name: L-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.16] synonym: "L-aspartate:oxygen oxidoreductase" EXACT [EC:1.4.3.16] xref: EC:1.4.3.16 xref: MetaCyc:L-ASPARTATE-OXID-RXN xref: MetaCyc:RXN-9772 xref: RHEA:25876 is_a: GO:0001716 ! L-amino-acid oxidase activity is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008735 name: carnitine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O." [EC:4.2.1.89, RHEA:14577] synonym: "L-carnitine dehydratase activity" EXACT [] synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] xref: EC:4.2.1.89 xref: KEGG_REACTION:R01925 xref: MetaCyc:CARNDEHYDRA-RXN xref: RHEA:14577 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008736 name: L-fucose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] xref: EC:5.3.1.25 xref: MetaCyc:FUCISOM-RXN xref: RHEA:17233 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008737 name: L-fuculokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.51, RHEA:12376] synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] xref: EC:2.7.1.51 xref: KEGG_REACTION:R03241 xref: MetaCyc:FUCULOKIN-RXN xref: RHEA:12376 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008738 name: L-fuculose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12933] synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] xref: EC:4.1.2.17 xref: KEGG_REACTION:R02262 xref: MetaCyc:FUCPALDOL-RXN xref: RHEA:12933 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008740 name: L-rhamnose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14, RHEA:23160] synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] xref: EC:5.3.1.14 xref: KEGG_REACTION:R02437 xref: MetaCyc:RHAMNISOM-RXN xref: RHEA:23160 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008741 name: ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: MetaCyc:RIBULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008742 name: L-ribulose-phosphate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22368] synonym: "AraD" RELATED [EC:5.1.3.4] synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] synonym: "L-Ru5P" RELATED [EC:5.1.3.4] synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] xref: EC:5.1.3.4 xref: KEGG_REACTION:R05850 xref: MetaCyc:RIBULPEPIM-RXN xref: RHEA:22368 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008743 name: L-threonine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH." [EC:1.1.1.103, RHEA:25657] synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] synonym: "threonine 3-dehydrogenase activity" BROAD [] synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] xref: EC:1.1.1.103 xref: KEGG_REACTION:R01465 xref: MetaCyc:THREODEHYD-RXN xref: Reactome:R-HSA-6798667 "TDH tetramer oxidises L-Thr to 2A-3OB" xref: RHEA:25657 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008744 name: L-xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] xref: EC:2.7.1.53 xref: MetaCyc:LYXK-RXN xref: RHEA:18869 is_a: GO:0004856 ! xylulokinase activity [Term] id: GO:0008745 name: N-acetylmuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28, PMID:22748813] synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] xref: EC:3.5.1.28 xref: MetaCyc:3.5.1.28-RXN xref: Reactome:R-HSA-6799977 "PGLYRP2 hydrolyzes bacterial peptidoglycan" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0008746 name: NAD(P)+ transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] xref: EC:1.6.1.1 xref: KEGG_REACTION:R00112 xref: Reactome:R-HSA-450971 "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]" xref: RHEA:11692 is_a: GO:0016652 ! oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor [Term] id: GO:0008747 name: N-acetylneuraminate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23296] synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] synonym: "NALase activity" EXACT [EC:4.1.3.3] synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "NPL" RELATED [EC:4.1.3.3] synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] xref: EC:4.1.3.3 xref: KEGG_REACTION:R01811 xref: MetaCyc:ACNEULY-RXN xref: Reactome:R-HSA-4085217 "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate" xref: RHEA:23296 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008748 name: N-ethylmaleimide reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101] xref: MetaCyc:RXN0-5101 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008750 name: NAD(P)+ transhydrogenase (AB-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf] synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] xref: EC:1.6.1.2 xref: MetaCyc:1.6.1.2-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity [Term] id: GO:0008751 name: obsolete NAD(P)H dehydrogenase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a redundant grouping term with only one child. synonym: "NAD(P)H dehydrogenase" EXACT [] is_obsolete: true consider: GO:0016651 [Term] id: GO:0008752 name: FMN reductase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0008753 name: NADPH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol." [EC:1.6.5.10] synonym: "NADPH oxidase" BROAD [EC:1.6.5.10] synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.5.10] synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.5.10] xref: EC:1.6.5.10 xref: KEGG_REACTION:R07359 xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN xref: RHEA:13149 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0008754 name: O antigen ligase activity namespace: molecular_function def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294] xref: MetaCyc:RXN0-5294 is_a: GO:0016874 ! ligase activity [Term] id: GO:0008755 name: O antigen polymerase activity namespace: molecular_function def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108] synonym: "O-antigen polymerase activity" EXACT [] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008756 name: o-succinylbenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] xref: EC:6.2.1.26 xref: KEGG_REACTION:R04030 xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN xref: RHEA:17009 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008757 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008758 name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] xref: MetaCyc:LIPIDXSYNTHESIS-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008759 name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] xref: EC:3.5.1.108 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008760 name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18681] synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] xref: EC:2.5.1.7 xref: KEGG_REACTION:R00660 xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN xref: RHEA:18681 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008761 name: UDP-N-acetylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] xref: EC:5.1.3.14 xref: MetaCyc:UDPGLCNACEPIM-RXN xref: Reactome:R-HSA-4085021 "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP" xref: Reactome:R-HSA-4088338 "Defective GNE does not hydrolyse UDP-GlcNAc" xref: RHEA:17213 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008762 name: UDP-N-acetylmuramate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.3.1.98] synonym: "MurB reductase" RELATED [EC:1.3.1.98] synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.3.1.98] synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.3.1.98] synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.3.1.98] synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.98] synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.3.1.98] synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.3.1.98] synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.3.1.98] xref: EC:1.3.1.98 xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN xref: RHEA:12248 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008763 name: UDP-N-acetylmuramate-L-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23372] synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] xref: EC:6.3.2.8 xref: KEGG_REACTION:R03193 xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN xref: RHEA:23372 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008764 name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9, RHEA:16429] synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] xref: EC:6.3.2.9 xref: KEGG_REACTION:R02783 xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN xref: RHEA:16429 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008765 name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23676] synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] xref: EC:6.3.2.13 xref: KEGG_REACTION:R02788 xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN xref: RHEA:23676 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008766 name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). xref: EC:6.3.2 xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008767 name: UDP-galactopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] xref: EC:5.4.99.9 xref: MetaCyc:GALPMUT-RXN xref: RHEA:24132 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0008768 name: UDP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] xref: EC:3.6.1.45 xref: MetaCyc:UDPSUGARHYDRO-RXN xref: Reactome:R-HSA-6810464 "NUDT14 hydrolyses UDP-Glc to G1P and UMP" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008769 name: obsolete X-His dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "carnosinase activity" RELATED [EC:3.4.13.3] synonym: "dipeptidase M" RELATED [EC:3.4.13.3] synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] synonym: "X-His dipeptidase activity" EXACT [] synonym: "Xaa-His dipeptidase activity" EXACT [] xref: EC:3.4.13.3 xref: MetaCyc:3.4.13.3-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0008770 name: [acyl-carrier-protein] phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] synonym: "ACP phosphodiesterase activity" EXACT [] synonym: "AcpH" RELATED [EC:3.1.4.14] synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: MetaCyc:3.1.4.14-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008771 name: [citrate (pro-3S)-lyase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: KEGG_REACTION:R04449 xref: MetaCyc:CITC-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008772 name: [isocitrate dehydrogenase (NADP+)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] synonym: "ICDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] synonym: "IDH-K/P" RELATED [EC:2.7.11.5] synonym: "IDHK/P" BROAD [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] xref: EC:2.7.11.5 xref: MetaCyc:PHOSICITDEHASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0008773 name: [protein-PII] uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: MetaCyc:URITRANS-RXN is_a: GO:0070569 ! uridylyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008774 name: acetaldehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] synonym: "ADA" RELATED [EC:1.2.1.10] synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] synonym: "DmpF" RELATED [EC:1.2.1.10] xref: EC:1.2.1.10 xref: MetaCyc:ACETALD-DEHYDROG-RXN xref: RHEA:23288 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008775 name: acetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] xref: EC:2.8.3.8 xref: MetaCyc:ACECOATRANS-RXN xref: Reactome:R-HSA-2066788 "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase" xref: RHEA:13381 xref: UM-BBD_enzymeID:e0012 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008776 name: acetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] synonym: "acetokinase activity" EXACT [EC:2.7.2.1] synonym: "AckA" RELATED [EC:2.7.2.1] synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: MetaCyc:ACETATEKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008777 name: acetylornithine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] xref: EC:3.5.1.16 xref: MetaCyc:ACETYLORNDEACET-RXN xref: RHEA:15941 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008779 name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: MetaCyc:ACYLGPEACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008780 name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008781 name: N-acylneuraminate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] xref: EC:2.7.7.43 xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-4084982 "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac" xref: RHEA:11344 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008782 name: adenosylhomocysteine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008783 name: agmatinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea." [EC:3.5.3.11, RHEA:13929] synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] synonym: "SpeB" RELATED [EC:3.5.3.11] xref: EC:3.5.3.11 xref: KEGG_REACTION:R01157 xref: MetaCyc:AGMATIN-RXN xref: Reactome:R-HSA-350604 "Agmatine + H2O <=> putrescine + urea" xref: RHEA:13929 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0008784 name: alanine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20249] synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] xref: EC:5.1.1.1 xref: KEGG_REACTION:R00401 xref: MetaCyc:ALARACECAT-RXN xref: RHEA:20249 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008785 name: alkyl hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_reactionID:r0684] xref: Reactome:R-HSA-1222526 "AhpC reduces peroxidated lipids" xref: UM-BBD_reactionID:r0684 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0008786 name: allose 6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] xref: MetaCyc:RXN0-303 xref: RHEA:28430 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008787 name: allose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] synonym: "allokinase activity" EXACT [EC:2.7.1.55] synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] xref: EC:2.7.1.55 xref: MetaCyc:ALLOSE-KINASE-RXN xref: RHEA:14805 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008788 name: alpha,alpha-phosphotrehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] xref: EC:3.2.1.93 xref: MetaCyc:TRE6PHYDRO-RXN xref: RHEA:23008 is_a: GO:0015927 ! trehalase activity [Term] id: GO:0008789 name: altronate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.7, RHEA:15957] synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] xref: EC:4.2.1.7 xref: KEGG_REACTION:R01540 xref: MetaCyc:ALTRODEHYDRAT-RXN xref: RHEA:15957 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008790 name: arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] xref: EC:5.3.1.3 xref: MetaCyc:DARABISOM-RXN xref: RHEA:13849 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008791 name: arginine N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] synonym: "AOST activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "AST activity" EXACT [EC:2.3.1.109] synonym: "AstA" RELATED [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] xref: EC:2.3.1.109 xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN xref: RHEA:15185 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008792 name: arginine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2)." [EC:4.1.1.19, RHEA:17641] synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] synonym: "SpeA" RELATED [EC:4.1.1.19] xref: EC:4.1.1.19 xref: KEGG_REACTION:R00566 xref: MetaCyc:ARGDECARBOX-RXN xref: Reactome:R-HSA-350598 "Arginine<=>Agmatine+CO2" xref: RHEA:17641 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008793 name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] synonym: "ArAT" RELATED [EC:2.6.1.57] synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] synonym: "aromatic amino acid transferase activity" EXACT [] synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: MetaCyc:2.6.1.57-RXN xref: UM-BBD_reactionID:r0297 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008794 name: arsenate reductase (glutaredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: MetaCyc:RXN-982 xref: UM-BBD_reactionID:r0635 is_a: GO:0030611 ! arsenate reductase activity is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [Term] id: GO:0008795 name: NAD+ synthase activity namespace: molecular_function alt_id: GO:0008749 alt_id: GO:0016965 def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD synthase (AMP-forming)" EXACT [] synonym: "NAD synthase activity" EXACT [] synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] xref: EC:6.3.1.5 xref: MetaCyc:NAD-SYNTH-NH3-RXN xref: RHEA:21188 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008796 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] xref: EC:3.6.1 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0008797 name: aspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] synonym: "aspartase activity" EXACT [EC:4.3.1.1] synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] xref: EC:4.3.1.1 xref: MetaCyc:ASPARTASE-RXN xref: RHEA:16601 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008798 name: beta-aspartyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] xref: EC:3.4.19.5 xref: MetaCyc:3.4.19.5-RXN xref: Reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)" xref: Reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe" is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0008800 name: beta-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] synonym: "neutrapen" RELATED [EC:3.5.2.6] synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0008801 name: beta-phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20113] synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] xref: EC:5.4.2.6 xref: KEGG_REACTION:R02728 xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN xref: RHEA:20113 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008802 name: betaine-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] synonym: "BADH activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] synonym: "BetB" RELATED [EC:1.2.1.8] xref: EC:1.2.1.8 xref: MetaCyc:BADH-RXN xref: Reactome:R-HSA-6797955 "ALDH7A1 oxidises BETALD to BET" xref: RHEA:15305 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0008803 name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+)." [EC:3.6.1.41, RHEA:24252] synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] xref: EC:3.6.1.41 xref: KEGG_REACTION:R00125 xref: MetaCyc:3.6.1.41-RXN xref: RHEA:24252 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0008804 name: carbamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "CKase activity" EXACT [EC:2.7.2.2] xref: EC:2.7.2.2 xref: MetaCyc:CARBAMATE-KINASE-RXN xref: RHEA:10152 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008805 name: carbon-monoxide oxygenase activity namespace: molecular_function alt_id: GO:0018999 alt_id: GO:0047767 def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] synonym: "carbon monoxide oxygenase activity" EXACT [] synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: MetaCyc:1.2.2.4-RXN xref: UM-BBD_reactionID:r0650 xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008806 name: carboxymethylenebutenolidase activity namespace: molecular_function alt_id: GO:0018735 def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] xref: EC:3.1.1.45 xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN xref: RHEA:12372 xref: UM-BBD_enzymeID:e0066 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008807 name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] xref: EC:2.7.8.23 xref: MetaCyc:2.7.8.23-RXN xref: RHEA:14045 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008808 name: cardiolipin synthase activity namespace: molecular_function alt_id: GO:0043788 def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl] synonym: "cardiolipin synthase 2 activity" RELATED [] synonym: "cardiolipin synthetase 2 activity" RELATED [] synonym: "cardiolipin synthetase activity" BROAD [] synonym: "diphosphatidylglycerol synthase activity" EXACT [] xref: EC:2.7.8 xref: MetaCyc:CARDIOLIPSYN-RXN xref: RHEA:31451 is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0008809 name: carnitine racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] xref: MetaCyc:CARNRACE-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008810 name: cellulase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] synonym: "alkali cellulase activity" NARROW [EC:3.2.1.4] synonym: "avicelase activity" RELATED [EC:3.2.1.4] synonym: "beta-1,4-endoglucan hydrolase activity" BROAD [EC:3.2.1.4] synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] synonym: "celluase A" RELATED [EC:3.2.1.4] synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] synonym: "cellulase A 3" RELATED [EC:3.2.1.4] synonym: "cellulosin AP" RELATED [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanase activity" BROAD [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanohydrolase activity" BROAD [EC:3.2.1.4] synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.4] synonym: "endoglucanase activity" BROAD [EC:3.2.1.4] synonym: "endoglucanase D" RELATED [EC:3.2.1.4] synonym: "pancellase SS" RELATED [EC:3.2.1.4] xref: EC:3.2.1.4 xref: MetaCyc:RXN-2043 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0008811 name: chloramphenicol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18421] synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "CAT I" RELATED [EC:2.3.1.28] synonym: "CAT II" RELATED [EC:2.3.1.28] synonym: "CAT III" RELATED [EC:2.3.1.28] synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] xref: EC:2.3.1.28 xref: KEGG_REACTION:R03065 xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN xref: RHEA:18421 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008812 name: choline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17433] synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] xref: EC:1.1.99.1 xref: KEGG_REACTION:R01025 xref: MetaCyc:CHD-RXN xref: Reactome:R-HSA-6797961 "CHDH oxidises Cho to BETALD" xref: RHEA:17433 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0008813 name: chorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16505] synonym: "4-hydroxybenzoate synthetase activity" EXACT [] synonym: "chorismate pyruvate lyase activity" EXACT [] synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] synonym: "CL" RELATED [EC:4.1.3.40] synonym: "CPL" RELATED [EC:4.1.3.40] synonym: "UbiC" RELATED [EC:4.1.3.40] xref: EC:4.1.3.40 xref: KEGG_REACTION:R01302 xref: MetaCyc:CHORPYRLY-RXN xref: RHEA:16505 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008814 name: citrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] xref: EC:2.8.3.10 xref: MetaCyc:CITTRANS-RXN xref: RHEA:19405 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008815 name: citrate (pro-3S)-lyase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6, RHEA:10760] synonym: "citrase activity" EXACT [EC:4.1.3.6] synonym: "citratase activity" EXACT [EC:4.1.3.6] synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] synonym: "citrate lyase activity" EXACT [] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] synonym: "citritase activity" EXACT [EC:4.1.3.6] xref: EC:4.1.3.6 xref: KEGG_REACTION:R00362 xref: MetaCyc:CITLY-RXN xref: RHEA:10760 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008816 name: citryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] xref: EC:4.1.3.34 xref: MetaCyc:CITRYLY-RXN xref: RHEA:20812 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008817 name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] synonym: "CobA" RELATED [EC:2.5.1.17] synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] xref: EC:2.5.1.17 xref: MetaCyc:COBALADENOSYLTRANS-RXN xref: Reactome:R-HSA-3159253 "MMAB transfers adenosyl group from ATP to cob(I)alamin" xref: Reactome:R-HSA-3322125 "Defective MMAB does not transfer adenosyl group from ATP to B12s" xref: RHEA:14725 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008818 name: cobalamin 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] xref: MetaCyc:COBALAMIN5PSYN-RXN xref: RHEA:23560 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008819 name: cobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008820 name: cobinamide phosphate guanylyltransferase activity namespace: molecular_function alt_id: GO:0043753 def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate." [EC:2.7.7.62, RHEA:22712] synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] xref: EC:2.7.7.62 xref: KEGG_REACTION:R05222 xref: MetaCyc:COBINPGUANYLYLTRANS-RXN xref: RHEA:22712 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008821 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function alt_id: GO:0008844 def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.4 xref: MetaCyc:3.1.22.4-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008822 name: obsolete crotonobetaine/carnitine-CoA ligase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a bifunctional gene product. synonym: "crotonobetaine/carnitine-CoA ligase activity" EXACT [] is_obsolete: true consider: GO:0051108 consider: GO:0051109 [Term] id: GO:0008823 name: cupric reductase activity namespace: molecular_function def: "Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH." [PMID:10510271] xref: EC:1.16.1 xref: MetaCyc:R170-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0008824 name: cyanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104] comment: Note that this function was formerly EC:4.3.99.1. synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanase activity" EXACT [] synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate lyase activity" EXACT [] xref: EC:4.2.1.104 xref: MetaCyc:R524-RXN xref: RHEA:24653 xref: UM-BBD_reactionID:r0608 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0008825 name: cyclopropane-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: MetaCyc:2.1.1.79-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008826 name: cysteine sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaCyc:RXN0-279] synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1 xref: MetaCyc:RXN0-279 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0008827 name: cytochrome o ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] xref: EC:1.10.3 is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008828 name: dATP pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] xref: EC:3.6.1 xref: MetaCyc:RXN0-384 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008829 name: dCTP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] xref: EC:3.5.4.13 xref: MetaCyc:DCTP-DEAM-RXN xref: Reactome:R-HSA-180632 "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand" xref: RHEA:22680 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008830 name: dTDP-4-dehydrorhamnose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16969] synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] xref: EC:5.1.3.13 xref: KEGG_REACTION:R06514 xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN xref: RHEA:16969 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008831 name: dTDP-4-dehydrorhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21796] synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] xref: EC:1.1.1.133 xref: KEGG_REACTION:R02777 xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN xref: RHEA:21796 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008832 name: dGTPase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate." [EC:3.1.5.1, RHEA:15193] synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] xref: EC:3.1.5.1 xref: KEGG_REACTION:R01856 xref: MetaCyc:DGTPTRIPHYDRO-RXN xref: RHEA:15193 is_a: GO:0016793 ! triphosphoric monoester hydrolase activity [Term] id: GO:0008833 name: deoxyribonuclease IV (phage-T4-induced) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "endonuclease II" RELATED [EC:3.1.21.2] synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] xref: EC:3.1.21.2 xref: MetaCyc:3.1.21.2-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008834 name: di-trans,poly-cis-decaprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl diphosphate synthase activity" EXACT [] synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] xref: EC:2.5.1.31 xref: MetaCyc:RXN-8999 xref: RHEA:27551 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008835 name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity namespace: molecular_function alt_id: GO:0008485 def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [EC:3.5.4.26, RHEA:21868] synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] xref: EC:3.5.4.26 xref: KEGG_REACTION:R03459 xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN xref: RHEA:21868 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008836 name: diaminopimelate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15101] synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] xref: EC:4.1.1.20 xref: KEGG_REACTION:R00451 xref: MetaCyc:DIAMINOPIMDECARB-RXN xref: RHEA:15101 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008837 name: diaminopimelate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15393] synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] xref: EC:5.1.1.7 xref: KEGG_REACTION:R02735 xref: MetaCyc:DIAMINOPIMEPIM-RXN xref: RHEA:15393 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008838 name: diaminopropionate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] xref: EC:4.3.1.15 xref: MetaCyc:4.3.1.15-RXN xref: RHEA:22084 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008839 name: 4-hydroxy-tetrahydrodipicolinate reductase namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8] synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] synonym: "dihydrodipicolinate reductase activity" EXACT [] synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] xref: EC:1.17.1.8 xref: MetaCyc:DIHYDROPICRED-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008840 name: 4-hydroxy-tetrahydrodipicolinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14845] synonym: "DHDPS activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinate synthase activity" EXACT [] synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] xref: EC:4.3.3.7 xref: KEGG_REACTION:R02292 xref: MetaCyc:DIHYDRODIPICSYN-RXN xref: RHEA:14845 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008841 name: dihydrofolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] synonym: "DHFS activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] synonym: "FHFS activity" EXACT [EC:6.3.2.12] synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] xref: EC:6.3.2.12 xref: MetaCyc:DIHYDROFOLATESYNTH-RXN xref: RHEA:23584 is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0006761 ! dihydrofolate biosynthetic process [Term] id: GO:0008842 name: diphosphate-purine nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] xref: EC:2.7.1.143 xref: MetaCyc:2.7.1.143-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0008843 name: endochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] is_a: GO:0004568 ! chitinase activity [Term] id: GO:0008845 name: obsolete endonuclease VIII activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12713806] comment: This term was made obsolete because it represents a gene product. synonym: "endonuclease VIII activity" EXACT [] is_obsolete: true consider: GO:0000703 consider: GO:0003684 consider: GO:0003906 consider: GO:0004519 consider: GO:0008081 consider: GO:0019104 [Term] id: GO:0008846 name: obsolete endopeptidase La activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] comment: This term was made obsolete because it represents a gene product. synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] synonym: "endopeptidase La activity" EXACT [] synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] synonym: "gene lon proteins" RELATED [EC:3.4.21.53] synonym: "lon proteinase" NARROW [EC:3.4.21.53] synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] xref: EC:3.4.21.53 xref: MetaCyc:3.4.21.53-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008847 name: Enterobacter ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.21] synonym: "enterobacter ribonuclease activity" EXACT [EC:4.6.1.21] synonym: "Enterobacter RNase activity" EXACT [] xref: EC:4.6.1.21 xref: MetaCyc:3.1.27.6-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008848 name: obsolete enterobactin synthetase namespace: molecular_function alt_id: GO:0008850 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a process rather than a function. synonym: "enterobactin synthetase" EXACT [] synonym: "enterochelin synthetase activity" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_obsolete: true replaced_by: GO:0009239 [Term] id: GO:0008849 name: enterochelin esterase activity namespace: molecular_function def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] xref: MetaCyc:RXN0-1661 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008851 name: ethanolamine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] xref: EC:4.3.1.7 xref: MetaCyc:ETHAMLY-RXN xref: RHEA:15313 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008852 name: exodeoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] xref: EC:3.1.11.1 xref: MetaCyc:3.1.11.1-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008853 name: exodeoxyribonuclease III activity namespace: molecular_function def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] xref: EC:3.1.11.2 xref: MetaCyc:3.1.11.2-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008854 name: exodeoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] xref: EC:3.1.11.5 xref: MetaCyc:3.1.11.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008855 name: exodeoxyribonuclease VII activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] xref: EC:3.1.11.6 xref: MetaCyc:3.1.11.6-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008856 name: exodeoxyribonuclease X activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] xref: EC:3.1.11 xref: MetaCyc:3.1.22.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008859 name: exoribonuclease II activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] synonym: "RNase II" RELATED [EC:3.1.13.1] synonym: "RNase II activity" EXACT [] xref: EC:3.1.13.1 xref: MetaCyc:3.1.13.1-RXN is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008860 name: ferredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin-NAD reductase activity" EXACT [] synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity [Term] id: GO:0008861 name: formate C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "PFL" EXACT [] synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] synonym: "pyruvate formate:lyase activity" EXACT [] synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] xref: EC:2.3.1.54 xref: MetaCyc:PYRUVFORMLY-RXN xref: RHEA:11844 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008863 name: formate dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0018476 def: "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [EC:1.17.1.9, RHEA:15985] synonym: "FDH I" RELATED [EC:1.17.1.9] synonym: "FDH II" RELATED [EC:1.17.1.9] synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.17.1.9] synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.17.1.9] synonym: "formate hydrogenlyase" EXACT [EC:1.17.1.9] synonym: "formate-NAD oxidoreductase" EXACT [EC:1.17.1.9] synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.17.1.9] synonym: "formic acid dehydrogenase" EXACT [EC:1.17.1.9] synonym: "formic hydrogen-lyase" EXACT [EC:1.17.1.9] synonym: "N-FDH" RELATED [EC:1.17.1.9] synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.17.1.9] synonym: "NAD-formate dehydrogenase" EXACT [EC:1.17.1.9] synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.17.1.9] xref: EC:1.17.1.9 xref: KEGG_REACTION:R00519 xref: MetaCyc:1.2.1.2-RXN xref: MetaCyc:FORMATEDEHYDROG-RXN xref: RHEA:15985 xref: UM-BBD_reactionID:r0103 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008864 name: formyltetrahydrofolate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)." [EC:3.5.1.10, RHEA:19833] synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] xref: EC:3.5.1.10 xref: KEGG_REACTION:R00944 xref: MetaCyc:FORMYLTHFDEFORMYL-RXN xref: RHEA:19833 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008865 name: fructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] xref: EC:2.7.1.4 xref: MetaCyc:FRUCTOKINASE-RXN xref: RHEA:16125 is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0008866 name: fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH." [EC:1.1.1.57, RHEA:15729] synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] xref: EC:1.1.1.57 xref: KEGG_REACTION:R02454 xref: MetaCyc:MANNONOXIDOREDUCT-RXN xref: RHEA:15729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008867 name: galactarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [EC:4.2.1.42, RHEA:16005] synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] xref: EC:4.2.1.42 xref: KEGG_REACTION:R05608 xref: MetaCyc:GALACTARDEHYDRA-RXN xref: RHEA:16005 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008868 name: galactitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] xref: EC:1.1.1.251 xref: MetaCyc:1.1.1.251-RXN xref: RHEA:15137 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008869 name: galactonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O." [EC:4.2.1.6, RHEA:18649] synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] xref: EC:4.2.1.6 xref: KEGG_REACTION:R03033 xref: MetaCyc:GALACTONDEHYDRAT-RXN xref: RHEA:18649 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008870 name: galactoside O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: MetaCyc:GALACTOACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008871 name: aminoglycoside 2''-nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] xref: EC:2.7.7.46 xref: MetaCyc:2.7.7.46-RXN is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0008872 name: glucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] xref: EC:4.2.1.40 xref: MetaCyc:GLUCARDEHYDRA-RXN xref: RHEA:14573 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008873 name: gluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] xref: EC:1.1.1.215 xref: MetaCyc:1.1.1.215-RXN xref: RHEA:16653 is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008874 name: gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] xref: EC:1.1.1.69 xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008875 name: gluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008876 name: quinoprotein glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] comment: Note that this was EC:1.1.99.17. synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] xref: EC:1.1.5.2 xref: MetaCyc:GLUCDEHYDROG-RXN xref: RHEA:22152 is_a: GO:0004344 ! glucose dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008877 name: glucose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] xref: EC:3.1.3.10 xref: KEGG_REACTION:R00304 xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN xref: RHEA:19933 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0008878 name: glucose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12120] synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADGase activity" EXACT [] synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ADPG pyrophosphorylase activity" EXACT [] synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] xref: EC:2.7.7.27 xref: KEGG_REACTION:R00948 xref: MetaCyc:GLUC1PADENYLTRANS-RXN xref: RHEA:12120 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008879 name: glucose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15225] synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] xref: EC:2.7.7.24 xref: KEGG_REACTION:R02328 xref: MetaCyc:DTDPGLUCOSEPP-RXN xref: RHEA:15225 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0008880 name: glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] xref: EC:5.3.1.12 xref: MetaCyc:GLUCUROISOM-RXN xref: RHEA:13049 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008881 name: glutamate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12813] xref: EC:5.1.1.3 xref: KEGG_REACTION:R00260 xref: MetaCyc:GLUTRACE-RXN xref: RHEA:12813 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008882 name: [glutamate-ammonia-ligase] adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42] synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: MetaCyc:GSADENYLATION-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008883 name: glutamyl-tRNA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH." [EC:1.2.1.70, RHEA:12344] synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] xref: EC:1.2.1.70 xref: KEGG_REACTION:R04109 xref: MetaCyc:GLUTRNAREDUCT-RXN xref: RHEA:12344 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0008884 name: glutathionylspermidine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] xref: EC:3.5.1.78 xref: MetaCyc:GSPAMID-RXN xref: RHEA:17173 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008885 name: glutathionylspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] xref: EC:6.3.1.8 xref: MetaCyc:GSPSYN-RXN xref: RHEA:21272 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008886 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH." [EC:1.2.1.9, RHEA:14669] synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] xref: EC:1.2.1.9 xref: KEGG_REACTION:R01058 xref: MetaCyc:1.2.1.9-RXN xref: RHEA:14669 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008887 name: glycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23516] synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] synonym: "GK" RELATED [EC:2.7.1.31] synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] xref: EC:2.7.1.31 xref: KEGG_REACTION:R01514 xref: MetaCyc:GLY3KIN-RXN xref: Reactome:R-HSA-6799495 "GLYCTK phosphorylates DGA to 3PDGA" xref: RHEA:23516 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008888 name: glycerol dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13769] synonym: "glycerol dehydrogenase activity" BROAD [] synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: KEGG_REACTION:R01034 xref: MetaCyc:GLYCDEH-RXN xref: RHEA:13769 is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity [Term] id: GO:0008889 name: glycerophosphodiester phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] synonym: "gene hpd protein" RELATED [EC:3.1.4.46] synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] xref: EC:3.1.4.46 xref: MetaCyc:GLYCPDIESTER-RXN xref: Reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1" xref: Reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1" is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008890 name: glycine C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20736] synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] xref: EC:2.3.1.29 xref: KEGG_REACTION:R00371 xref: MetaCyc:AKBLIG-RXN xref: RHEA:20736 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008891 name: glycolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15] xref: MetaCyc:RXN-969 xref: Reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate" is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0008892 name: guanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] synonym: "GAH activity" EXACT [EC:3.5.4.3] synonym: "guanase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] xref: EC:3.5.4.3 xref: MetaCyc:GUANINE-DEAMINASE-RXN xref: Reactome:R-HSA-74255 "Guanine + H2O => Xanthine + NH4+" xref: RHEA:14665 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008893 name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] xref: EC:3.1.7.2 xref: MetaCyc:PPGPPSYN-RXN xref: RHEA:14253 is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0008894 name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] xref: EC:3.6.1.40 xref: MetaCyc:PPPGPPHYDRO-RXN xref: RHEA:13073 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008897 name: holo-[acyl-carrier-protein] synthase activity namespace: molecular_function alt_id: GO:0008958 def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] synonym: "AcpS" RELATED [EC:2.7.8.7] synonym: "ACPS activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] synonym: "holosynthase activity" RELATED [EC:2.7.8.7] synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] synonym: "phosphopantetheinyl transferase" RELATED [] synonym: "phosphopantetheinyltransferase activity" EXACT [] synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: MetaCyc:HOLO-ACP-SYNTH-RXN xref: Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008898 name: S-adenosylmethionine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10] synonym: "L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN xref: RHEA:21820 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008899 name: homoserine O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22008] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] xref: EC:2.3.1.46 xref: KEGG_REACTION:R01777 xref: MetaCyc:HOMSUCTRAN-RXN xref: RHEA:22008 is_a: GO:0016750 ! O-succinyltransferase activity [Term] id: GO:0008900 name: potassium:proton exchanging ATPase activity namespace: molecular_function alt_id: GO:0005390 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:7.2.2.19] synonym: "(K+ + H+)-ATPase activity" EXACT [EC:7.2.2.19] synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:7.2.2.19] synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] synonym: "gastric H+/K+ ATPase" NARROW [EC:7.2.2.19] synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:7.2.2.19] synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:7.2.2.19] synonym: "H+-K+-ATPase activity" EXACT [EC:7.2.2.19] synonym: "H+/K+-ATPase activity" EXACT [EC:7.2.2.19] synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:7.2.2.19] synonym: "H,K-ATPase activity" EXACT [EC:7.2.2.19] synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium-exchanging ATPase activity" EXACT [] synonym: "proton pump activity" BROAD [EC:3.6.3.10] xref: EC:7.2.2.19 xref: Reactome:R-HSA-937311 "ATP4A/12A:ATP4B exchanges K+ for H+" xref: RHEA:22044 is_a: GO:0008553 ! proton-exporting ATPase activity, phosphorylative mechanism is_a: GO:0008556 ! potassium transmembrane transporter activity, phosphorylative mechanism [Term] id: GO:0008901 name: ferredoxin hydrogenase activity namespace: molecular_function alt_id: GO:0016948 alt_id: GO:0016949 alt_id: GO:0016950 alt_id: GO:0016951 def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. synonym: "[Fe] hydrogenase activity" EXACT [] synonym: "[Fe] hydrogenase gamma" RELATED [] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H2 oxidizing hydrogenase" BROAD [] synonym: "H2 producing hydrogenase" BROAD [] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] synonym: "hydrogenase activity" BROAD [] synonym: "hydrogenase I" RELATED [] synonym: "hydrogenase II" RELATED [] synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] synonym: "iron hydrogenase activity" NARROW [] synonym: "iron-only hydrogenase activity" NARROW [] synonym: "Ni-Fe hydrogenase activity" NARROW [] synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] synonym: "nickel hydrogenase activity" NARROW [] synonym: "nickel-iron hydrogenase activity" NARROW [] synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: MetaCyc:HYDROG-RXN xref: UM-BBD_enzymeID:e0418 is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor [Term] id: GO:0008902 name: hydroxymethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+)." [EC:2.7.1.49, RHEA:23096] synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] xref: EC:2.7.1.49 xref: KEGG_REACTION:R03471 xref: MetaCyc:OHMETPYRKIN-RXN xref: RHEA:23096 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008903 name: hydroxypyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11952] synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] xref: EC:5.3.1.22 xref: KEGG_REACTION:R01394 xref: MetaCyc:RXN0-305 xref: RHEA:11952 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008904 name: hygromycin-B 7''-O-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+)." [EC:2.7.1.119, RHEA:23388] synonym: "APH(7'') activity" RELATED [EC:2.7.1.119] synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" EXACT [EC:2.7.1.119] synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] synonym: "hygromycin B kinase activity" BROAD [] synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119] synonym: "hygromycin-B kinase activity" BROAD [] xref: EC:2.7.1.119 xref: KEGG_REACTION:R03770 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN xref: RHEA:23388 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008905 name: mannose-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] xref: EC:2.7.7 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008906 name: inosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] xref: EC:2.7.1.73 xref: MetaCyc:INOSINEKIN-RXN xref: RHEA:21140 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008907 name: integrase activity namespace: molecular_function def: "Catalysis of the integration of one segment of DNA into another." [GOC:mah] subset: goslim_pir xref: Reactome:R-HSA-164523 "Transesterification to connect viral DNA 3' ends to host DNA 5' ends" is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0015074 ! DNA integration [Term] id: GO:0008908 name: isochorismatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11112] synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] xref: EC:3.3.2.1 xref: KEGG_REACTION:R03037 xref: MetaCyc:ISOCHORMAT-RXN xref: RHEA:11112 is_a: GO:0004463 ! leukotriene-A4 hydrolase activity [Term] id: GO:0008909 name: isochorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18985] comment: Note that this function was formerly EC:5.4.99.6. synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] synonym: "isochorismate mutase activity" EXACT [] synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] xref: EC:5.4.4.2 xref: KEGG_REACTION:R01717 xref: MetaCyc:ISOCHORSYN-RXN xref: RHEA:18985 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0008910 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256] synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "APH(3') activity" EXACT [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] xref: EC:2.7.1.95 xref: KEGG_REACTION:R01888 xref: MetaCyc:KANAMYCIN-KINASE-RXN xref: RHEA:24256 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008911 name: lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] xref: EC:1.2.1.22 xref: MetaCyc:LACTALDDEHYDROG-RXN xref: RHEA:14277 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0008912 name: lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77] synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77] synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] xref: EC:1.1.1.77 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008913 name: lauroyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732] synonym: "lauroyl transferase activity" EXACT [] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008914 name: leucyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: MetaCyc:LEUCYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0008915 name: lipid-A-disaccharide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP." [EC:2.4.1.182, RHEA:22668] synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] xref: EC:2.4.1.182 xref: KEGG_REACTION:R04606 xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN xref: RHEA:22668 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008917 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr, KEGG:00540] synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] xref: EC:2.4.1.56 xref: MetaCyc:2.4.1.56-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0008918 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr, KEGG:00540] synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] xref: EC:2.4.1.44 xref: MetaCyc:2.4.1.44-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0008919 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr, KEGG:00540] synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] xref: EC:2.4.1.58 xref: MetaCyc:2.4.1.58-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0008920 name: lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127] synonym: "LPS heptosyltransferase activity" EXACT [] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008921 name: lipopolysaccharide-1,6-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008922 name: long-chain fatty acid [acyl-carrier-protein] ligase activity namespace: molecular_function alt_id: GO:0010300 def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22." [EC:6.2.1.20] synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-ACP synthetase activity" EXACT [] synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: KEGG_REACTION:R07325 xref: MetaCyc:ACYLACPSYNTH-RXN is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0008923 name: lysine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2)." [EC:4.1.1.18, RHEA:22352] synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] xref: EC:4.1.1.18 xref: KEGG_REACTION:R00462 xref: MetaCyc:LYSDECARBOX-RXN xref: MetaCyc:PWY0-461 xref: RHEA:22352 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008924 name: malate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "(S)-malate:(quinone) oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "(S)-malate:quinone oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "FAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.5.4] synonym: "MQO activity" BROAD [EC:1.1.5.4] xref: EC:1.1.5.4 xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:22556 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008925 name: maltose O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] xref: EC:2.3.1.79 xref: MetaCyc:MALTACETYLTRAN-RXN xref: RHEA:10456 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008926 name: mannitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] xref: EC:1.1.1.17 xref: MetaCyc:MANNPDEHYDROG-RXN xref: RHEA:19661 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008927 name: mannonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20097] synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] xref: EC:4.2.1.8 xref: KEGG_REACTION:R05606 xref: MetaCyc:MANNONDEHYDRAT-RXN xref: RHEA:20097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008928 name: mannose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate." [EC:2.7.7.22, RHEA:12905] synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] xref: EC:2.7.7.22 xref: KEGG_REACTION:R00883 xref: MetaCyc:MANNPGUANYLTRANGDP-RXN xref: RHEA:12905 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0008929 name: methylglyoxal synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17937] synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] xref: EC:4.2.3.3 xref: KEGG_REACTION:R01016 xref: MetaCyc:METHGLYSYN-RXN xref: RHEA:17937 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0008930 name: methylthioadenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] xref: EC:3.2.2.16 xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN xref: RHEA:13617 is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0008931 name: obsolete murein DD-endopeptidase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "murein DD-endopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008932 name: lytic endotransglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] synonym: "murein lytic endotransglycosylase E activity" NARROW [] xref: EC:2.4.99 is_a: GO:0008933 ! lytic transglycosylase activity [Term] id: GO:0008933 name: lytic transglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424, PMID:22748813] synonym: "murein transglycosylase B activity" NARROW [] synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0008934 name: inositol monophosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:RXN0-5408 xref: Reactome:R-HSA-1855154 "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol" xref: RHEA:27670 is_a: GO:0052834 ! inositol monophosphate phosphatase activity [Term] id: GO:0008935 name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-napthoyl-CoA + H2O." [EC:4.1.3.36] synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase activity" RELATED [KEGG_REACTION:R04150] xref: EC:4.1.3.36 xref: KEGG_REACTION:R04150 xref: MetaCyc:NAPHTHOATE-SYN-RXN xref: RHEA:15525 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008936 name: nicotinamidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] synonym: "NAMase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] synonym: "YNDase activity" EXACT [EC:3.5.1.19] xref: EC:3.5.1.19 xref: MetaCyc:NICOTINAMID-RXN xref: RHEA:14545 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008937 name: ferredoxin-NAD(P) reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] synonym: "ferredoxin reductase activity" BROAD [] xref: EC:1.18.1 is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008938 name: nicotinate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20241] synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] xref: EC:2.1.1.7 xref: KEGG_REACTION:R01721 xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN xref: RHEA:20241 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008939 name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate." [EC:2.4.2.21, RHEA:11196] synonym: "CobT" RELATED [EC:2.4.2.21] synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] xref: EC:2.4.2.21 xref: KEGG_REACTION:R04148 xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN xref: RHEA:11196 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008940 name: nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4] synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] xref: EC:1.7.99.4 xref: MetaCyc:NITRATREDUCT-RXN xref: RHEA:21068 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0008941 name: nitric oxide dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [EC:1.14.12.17] synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] synonym: "NOD activity" EXACT [EC:1.14.12.17] xref: EC:1.14.12.17 xref: MetaCyc:R621-RXN xref: Reactome:R-HSA-1222723 "Nitric oxide is oxidized to nitrate" xref: Reactome:R-HSA-5340226 "CYGB dioxygenates NO" is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008942 name: nitrite reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] comment: Note that this function was formerly EC:1.6.6.4. synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] xref: EC:1.7.1.4 xref: KEGG_REACTION:R00787 xref: KEGG_REACTION:R00789 xref: MetaCyc:NITRITREDUCT-RXN xref: RHEA:24628 xref: RHEA:24632 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor is_a: GO:0098809 ! nitrite reductase activity [Term] id: GO:0008943 name: obsolete glyceraldehyde-3-phosphate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] comment: This term was made obsolete because it is a grouping term based on similar names. synonym: "glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] is_obsolete: true consider: GO:0004365 consider: GO:0008886 consider: GO:0043878 consider: GO:0047100 [Term] id: GO:0008944 name: obsolete oligopeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] comment: This term was made obsolete because it represents a gene product. synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] synonym: "oligopeptidase A activity" EXACT [] xref: EC:3.4.24.70 xref: MetaCyc:3.4.24.70-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008945 name: obsolete oligopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] comment: This term was made obsolete because it represents a gene product. synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "oligopeptidase B activity" EXACT [] synonym: "protease II activity" EXACT [EC:3.4.21.83] xref: EC:3.4.21.83 xref: MetaCyc:3.4.21.83-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008946 name: oligonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. xref: EC:3.1.13.3 xref: MetaCyc:3.1.13.3-RXN is_a: GO:0004518 ! nuclease activity [Term] id: GO:0008947 name: obsolete omptin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] comment: This term was made obsolete because it represents a gene product. synonym: "omptin activity" EXACT [] xref: EC:3.4.21.87 xref: MetaCyc:3.4.21.87-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008948 name: oxaloacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.112] synonym: "oxalacetic acid decarboxylase activity" EXACT [] synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.112] synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.112] synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [] synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.112] xref: EC:1.1.1.38 xref: EC:1.1.1.40 xref: EC:4.1.1.112 xref: KEGG_REACTION:R00217 xref: MetaCyc:OXALODECARB-RXN xref: Reactome:R-HSA-9012016 "FAHD1:Zn2+ dimer hydrolyses OA to PYR" xref: RHEA:15641 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008949 name: oxalyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19333] synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] xref: EC:4.1.1.8 xref: KEGG_REACTION:R01908 xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN xref: RHEA:19333 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008950 name: obsolete p-aminobenzoate synthetase namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. synonym: "p-aminobenzoate synthetase" EXACT [] is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008951 name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN] synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: MetaCyc:PALMITOTRANS-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008953 name: penicillin amidase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "novozym 217" RELATED [EC:3.5.1.11] synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] synonym: "semacylase activity" EXACT [EC:3.5.1.11] xref: EC:3.5.1.11 xref: MetaCyc:PENICILLIN-AMIDASE-RXN xref: RHEA:18693 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008954 name: obsolete peptidoglycan synthetase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities. synonym: "peptidoglycan synthetase activity" EXACT [] is_obsolete: true consider: GO:0008955 consider: GO:0071972 [Term] id: GO:0008955 name: peptidoglycan glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: MetaCyc:RXN0-5405 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008956 name: obsolete peptidyl-dipeptidase Dcp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] comment: This term was made obsolete because it represents a gene product. synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] synonym: "peptidyl-dipeptidase Dcp activity" EXACT [] xref: EC:3.4.15.5 xref: MetaCyc:3.4.15.5-RXN is_obsolete: true consider: GO:0008235 consider: GO:0008241 [Term] id: GO:0008957 name: phenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] xref: EC:1.2.1.39 xref: MetaCyc:PHENDEHYD-RXN xref: RHEA:21392 xref: UM-BBD_reactionID:r0035 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0008959 name: phosphate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] synonym: "PTA" RELATED [EC:2.3.1.8] xref: EC:2.3.1.8 xref: MetaCyc:PHOSACETYLTRANS-RXN xref: RHEA:19521 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0008960 name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] xref: EC:2.7.8.20 xref: MetaCyc:PGLYCEROLTRANSI-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008961 name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity namespace: molecular_function def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008962 name: phosphatidylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] xref: EC:3.1.3.27 xref: MetaCyc:PGPPHOSPHA-RXN xref: Reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG" xref: RHEA:16725 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008964 name: phosphoenolpyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-." [EC:4.1.1.31] synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] synonym: "PEPC" RELATED [EC:4.1.1.31] synonym: "PEPCase activity" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] xref: EC:4.1.1.31 xref: KEGG_REACTION:R00345 xref: MetaCyc:PEPCARBOX-RXN xref: RHEA:28370 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0008965 name: phosphoenolpyruvate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: MetaCyc:2.7.3.9-RXN is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0008966 name: phosphoglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23424] synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] xref: EC:5.4.2.10 xref: KEGG_REACTION:R02060 xref: MetaCyc:5.4.2.10-RXN xref: RHEA:23424 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008967 name: phosphoglycolate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14369] synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] xref: EC:3.1.3.18 xref: KEGG_REACTION:R01334 xref: MetaCyc:GPH-RXN xref: RHEA:14369 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008968 name: D-sedoheptulose 7-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] synonym: "phosphoheptose isomerase activity" EXACT [] xref: MetaCyc:RXN0-4301 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008970 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: goslim_chembl synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN xref: Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C" xref: Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]" xref: Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)" xref: Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]" xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C" xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]" xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]" xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC" is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008972 name: phosphomethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] xref: EC:2.7.4.7 xref: MetaCyc:PYRIMSYN3-RXN xref: RHEA:19893 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008973 name: phosphopentomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] xref: EC:5.4.2.7 xref: MetaCyc:PPENTOMUT-RXN xref: Reactome:R-HSA-6787329 "PGM2:Mg2+ isomerises R1P to R5P" xref: Reactome:R-HSA-8982667 "PGM2:Mg2+ isomerises dR1P to dR5P" xref: RHEA:18793 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008974 name: phosphoribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19365] synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] synonym: "PKK" RELATED [EC:2.7.1.19] synonym: "PRK" RELATED [EC:2.7.1.19] synonym: "PRuK" RELATED [EC:2.7.1.19] synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] xref: EC:2.7.1.19 xref: KEGG_REACTION:R01523 xref: MetaCyc:PHOSPHORIBULOKINASE-RXN xref: RHEA:19365 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008975 name: obsolete pitrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] comment: This term was made obsolete because it represents a gene product. synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] synonym: "pitrilysin activity" EXACT [] synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] xref: EC:3.4.24.55 xref: MetaCyc:3.4.24.55-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008976 name: polyphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "polyphosphate polymerase activity" EXACT [] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008977 name: prephenate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." [EC:1.3.1.12, RHEA:13869] synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] xref: EC:1.3.1.12 xref: KEGG_REACTION:R01728 xref: MetaCyc:PREPHENATEDEHYDROG-RXN xref: RHEA:13869 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008978 name: obsolete prepilin peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] comment: This term was made obsolete because it represents a gene product. synonym: "prepilin peptidase activity" EXACT [] xref: EC:3.4.23.43 xref: MetaCyc:3.4.23.43-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0008979 name: prophage integrase activity namespace: molecular_function def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA." [GOC:jl] synonym: "integrase activity involved in establishment of integrated proviral latency" EXACT [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity relationship: part_of GO:0075713 ! establishment of integrated proviral latency [Term] id: GO:0008980 name: propionate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15] synonym: "ATP:propanoate phosphotransferase activity" EXACT [] synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008981 name: obsolete protease IV activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "protease IV activity" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008982 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity namespace: molecular_function alt_id: GO:0015455 alt_id: GO:0015456 def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] synonym: "gene glC proteins" RELATED [EC:2.7.1.69] synonym: "group translocator activity" RELATED [EC:2.7.1.69] synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphotransfer-driven group translocator" EXACT [] synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "PTS permease activity" EXACT [EC:2.7.1.69] synonym: "PTS transporter" RELATED [EC:2.7.1.69] synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] xref: EC:2.7.1.69 xref: MetaCyc:2.7.1.69-RXN is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0008983 name: protein-glutamate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein methylase II" RELATED [EC:2.1.1.80] synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] xref: EC:2.1.1.80 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0008984 name: protein-glutamate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] xref: EC:3.1.1.61 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0008985 name: obsolete pyruvate dehydrogenase (cytochrome) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] comment: This term was made obsolete because the EC activity it represents, EC:1.2.2.2, has been deleted. synonym: "pyruvate dehydrogenase (cytochrome) activity" EXACT [] synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.2] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.2.2] synonym: "pyruvic (cytochrome b1) dehydrogenase activity" RELATED [EC:1.2.2.2] is_obsolete: true replaced_by: GO:0052737 [Term] id: GO:0008986 name: pyruvate, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate." [EC:2.7.9.2, RHEA:11364] synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] synonym: "PEP synthase activity" EXACT [] synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] synonym: "water pyruvate dikinase activity" EXACT [] xref: EC:2.7.9.2 xref: KEGG_REACTION:R00199 xref: MetaCyc:PEPSYNTH-RXN xref: RHEA:11364 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0008987 name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] xref: MetaCyc:QUINOLINATE-SYNTHA-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups relationship: part_of GO:0019805 ! quinolinate biosynthetic process [Term] id: GO:0008988 name: rRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0008989 name: rRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [GOC:curators] synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008990 name: rRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] xref: EC:2.1.1.52 xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008991 name: obsolete serine-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "serine-type signal peptidase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008992 name: obsolete repressor LexA activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] comment: This term was made obsolete because it represents a gene product. synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] synonym: "repressor LexA activity" EXACT [] xref: EC:3.4.21.88 xref: MetaCyc:3.4.21.88-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008993 name: rhamnulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "RhuK" RELATED [EC:2.7.1.5] xref: EC:2.7.1.5 xref: MetaCyc:RHAMNULOKIN-RXN xref: RHEA:20117 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008994 name: rhamnulose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] xref: EC:4.1.2.19 xref: MetaCyc:RHAMNULPALDOL-RXN xref: RHEA:19689 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008995 name: ribonuclease E activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] xref: MetaCyc:3.1.26.12-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008996 name: ribonuclease G activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008997 name: ribonuclease R activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] xref: EC:3.1.11 is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008998 name: ribonucleoside-triphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] xref: EC:1.17.4.2 xref: MetaCyc:1.17.4.2-RXN xref: RHEA:12701 is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0008999 name: ribosomal-protein-alanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: MetaCyc:2.3.1.128-RXN is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity [Term] id: GO:0009000 name: selenocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by SCLY" xref: RHEA:11632 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0009001 name: serine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24560] synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "SATase activity" EXACT [EC:2.3.1.30] synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] xref: EC:2.3.1.30 xref: KEGG_REACTION:R00586 xref: MetaCyc:SERINE-O-ACETTRAN-RXN xref: RHEA:24560 is_a: GO:0016412 ! serine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0009002 name: serine-type D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] xref: EC:3.4.16.4 xref: MetaCyc:3.4.16.4-RXN is_a: GO:0004185 ! serine-type carboxypeptidase activity [Term] id: GO:0009003 name: obsolete signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "signal peptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0008233 [Term] id: GO:0009004 name: obsolete signal peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] comment: This term was made obsolete because it represents a gene product. synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "HOSP" RELATED [EC:3.4.21.89] synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] synonym: "leader peptidase I" RELATED [EC:3.4.21.89] synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "propeptidase activity" EXACT [EC:3.4.21.89] synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] synonym: "signal peptidase I activity" EXACT [] synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] xref: EC:3.4.21.89 xref: MetaCyc:3.4.21.89-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0009005 name: obsolete signal peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] comment: This term was made obsolete because it represents a gene product. synonym: "leader peptidase II" RELATED [EC:3.4.23.36] synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "signal peptidase II activity" EXACT [] synonym: "SPase II activity" EXACT [EC:3.4.23.36] xref: EC:3.4.23.36 xref: MetaCyc:3.4.23.36-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009006 name: obsolete siroheme synthase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents three different molecular functions. synonym: "sirohaem synthase activity" EXACT [] synonym: "siroheme synthase activity" EXACT [] is_obsolete: true consider: GO:0004851 consider: GO:0019354 consider: GO:0043115 consider: GO:0051266 [Term] id: GO:0009007 name: site-specific DNA-methyltransferase (adenine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] synonym: "DNA adenine methylase" BROAD [] synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] synonym: "modification methylase activity" RELATED [EC:2.1.1.72] synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: MetaCyc:2.1.1.72-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0032775 ! DNA methylation on adenine [Term] id: GO:0009008 name: DNA-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732, PMID:7862522] synonym: "deoxyribonucleate methylase activity" EXACT [] synonym: "deoxyribonucleate methyltransferase activity" EXACT [] synonym: "deoxyribonucleic acid methylase activity" EXACT [] synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [] synonym: "deoxyribonucleic acid modification methylase activity" RELATED [] synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: Reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0006306 ! DNA methylation [Term] id: GO:0009009 name: site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. subset: goslim_pir is_a: GO:0000150 ! recombinase activity [Term] id: GO:0009010 name: sorbitol-6-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] xref: EC:1.1.1.140 xref: MetaCyc:SORB6PDEHYDROG-RXN xref: RHEA:19837 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009011 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] xref: EC:2.4.1.21 xref: MetaCyc:GLYCOGENSYN-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0009012 name: aminoglycoside 3''-adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+)." [EC:2.7.7.47, RHEA:20245] synonym: "AAD (3'')" RELATED [EC:2.7.7.47] synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] xref: EC:2.7.7.47 xref: KEGG_REACTION:R02226 xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN xref: RHEA:20245 is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0009013 name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] xref: EC:1.2.1.16 xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN xref: UM-BBD_reactionID:r0371 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0009014 name: succinyl-diaminopimelate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22608] synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] xref: EC:3.5.1.18 xref: KEGG_REACTION:R02734 xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN xref: RHEA:22608 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009015 name: N-succinylarginine dihydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+)." [EC:3.5.3.23, RHEA:19533] synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] synonym: "arginine succinylhydrolase activity" EXACT [] synonym: "AruB" RELATED [] synonym: "AstB" RELATED [] synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] synonym: "N2-succinylarginine dihydrolase activity" EXACT [] synonym: "SADH" RELATED [] synonym: "succinylarginine dihydrolase activity" EXACT [] xref: EC:3.5.3.23 xref: KEGG_REACTION:R04189 xref: MetaCyc:SUCCARGDIHYDRO-RXN xref: RHEA:19533 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0009016 name: succinyldiaminopimelate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11960] synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] xref: EC:2.6.1.17 xref: KEGG_REACTION:R04475 xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN xref: RHEA:11960 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009017 name: succinylglutamate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15169] synonym: "AstE" RELATED [] synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] synonym: "SGDS" RELATED [] xref: EC:3.5.1.96 xref: KEGG_REACTION:R00411 xref: MetaCyc:SUCCGLUDESUCC-RXN xref: RHEA:15169 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009018 name: sucrose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] xref: EC:2.4.1.7 xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN xref: RHEA:24048 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0009019 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: Reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)" xref: Reactome:R-HSA-6786621 "TRMT10A methylates guanosine-9 in tRNA" xref: Reactome:R-HSA-6787591 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009020 name: tRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: MetaCyc:2.1.1.34-RXN xref: Reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity [Term] id: GO:0009022 name: tRNA nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0009023 name: obsolete tRNA sulfurtransferase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] synonym: "tRNA sulfurtransferase" EXACT [] synonym: "tRNA sulphurtransferase activity" EXACT [] is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0009024 name: tagatose-6-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] xref: EC:2.7.1.144 xref: MetaCyc:TAGAKIN-RXN xref: RHEA:12420 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009025 name: tagatose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22948] synonym: "AgaY" RELATED [] synonym: "AgaZ" RELATED [] synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] synonym: "KbaY" RELATED [] synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] xref: EC:4.1.2.40 xref: KEGG_REACTION:R01069 xref: MetaCyc:TAGAALDOL-RXN xref: RHEA:22948 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0009026 name: tagaturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH." [EC:1.1.1.58, RHEA:17813] synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "TagUAR" RELATED [EC:1.1.1.58] xref: EC:1.1.1.58 xref: KEGG_REACTION:R02555 xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN xref: RHEA:17813 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009027 name: tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009028 name: tartronate-semialdehyde synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.47, RHEA:10136] synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] xref: EC:4.1.1.47 xref: KEGG_REACTION:R00013 xref: MetaCyc:GLYOCARBOLIG-RXN xref: RHEA:10136 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0009029 name: tetraacyldisaccharide 4'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a)." [EC:2.7.1.130, RHEA:20700] synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] xref: EC:2.7.1.130 xref: KEGG_REACTION:R04657 xref: MetaCyc:TETRAACYLDISACC4KIN-RXN xref: RHEA:20700 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009030 name: thiamine-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate." [EC:2.7.4.16, RHEA:15913] synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin phosphate kinase activity" EXACT [] synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-phosphate kinase activity" EXACT [] synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] xref: EC:2.7.4.16 xref: KEGG_REACTION:R00617 xref: MetaCyc:THI-P-KIN-RXN xref: RHEA:15913 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0009032 name: thymidine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "gliostatins" RELATED [EC:2.4.2.4] synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] xref: EC:2.4.2.4 xref: MetaCyc:THYM-PHOSPH-RXN xref: RHEA:16037 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0009033 name: trimethylamine-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [GOC:curators, RHEA:22024] synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [] synonym: "trimethylamine N-oxide reductase" EXACT [] synonym: "trimethylamine oxidase activity" EXACT [] synonym: "trimethylamine oxide reductase" EXACT [] xref: MetaCyc:TMAOREDUCT-RXN xref: RHEA:22024 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0009034 name: tryptophanase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate." [EC:4.1.99.1, RHEA:19553] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] synonym: "TNase activity" EXACT [EC:4.1.99.1] synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] xref: EC:4.1.99.1 xref: KEGG_REACTION:R00673 xref: MetaCyc:TRYPDEG-PWY xref: MetaCyc:TRYPTOPHAN-RXN xref: RHEA:19553 xref: UniPathway:UPA00332 is_a: GO:0016830 ! carbon-carbon lyase activity relationship: part_of GO:0006569 ! tryptophan catabolic process [Term] id: GO:0009035 name: type I site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] synonym: "type I restriction enzyme activity" EXACT [] synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] xref: EC:3.1.21.3 xref: MetaCyc:3.1.21.3-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009036 name: type II site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] synonym: "type II restriction enzyme activity" EXACT [] xref: EC:3.1.21.4 xref: MetaCyc:3.1.21.4-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009037 name: tyrosine-based site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] synonym: "site-specific tyrosine recombinase activity" EXACT [] synonym: "tyrosine recombinase" BROAD [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity [Term] id: GO:0009038 name: undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66, RHEA:23752] synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66] xref: EC:2.7.1.66 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009039 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: MetaCyc:UREASE-RXN xref: RHEA:25346 xref: UM-BBD_reactionID:r0120 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009040 name: ureidoglycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+." [EC:1.1.1.154, PMID:23284870] synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] xref: EC:1.1.1.154 xref: MetaCyc:R165-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009041 name: uridylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] xref: EC:2.7.4.22 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0009042 name: valine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22912] synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "transaminase C activity" NARROW [EC:2.6.1.66] synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "valine-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.66 xref: KEGG_REACTION:R01215 xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN xref: RHEA:22912 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009044 name: xylan 1,4-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "xylobiase activity" EXACT [EC:3.2.1.37] xref: EC:3.2.1.37 xref: MetaCyc:3.2.1.37-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0009045 name: xylose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] xref: EC:5.3.1.5 xref: MetaCyc:XYLISOM-RXN xref: RHEA:22816 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0009046 name: zinc D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] synonym: "G enzyme" RELATED [EC:3.4.17.14] synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] xref: EC:3.4.17.14 xref: MetaCyc:3.4.17.14-RXN is_a: GO:0004181 ! metallocarboxypeptidase activity [Term] id: GO:0009047 name: dosage compensation by hyperactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0140512888, PMID:11498577, PMID:20622855] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009048 name: dosage compensation by inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:mr, GOC:pr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0140512888, PMID:11498577, PMID:20622855] synonym: "Barr body formation" RELATED [] synonym: "chromosome inactivation" BROAD [] synonym: "X chromosome inactivation" EXACT [] xref: MIPS_funcat:10.03.04.06 xref: Wikipedia:X-inactivation is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009049 name: obsolete aspartic-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "aspartic-type signal peptidase activity" EXACT [] xref: EC:3.4.23 is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009050 name: glycopeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732] synonym: "glycopeptide breakdown" EXACT [] synonym: "glycopeptide catabolism" EXACT [] synonym: "glycopeptide degradation" EXACT [] is_a: GO:0043171 ! peptide catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009051 name: pentose-phosphate shunt, oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY] synonym: "oxidative branch, pentose pathway" EXACT [] synonym: "oxidative pentose phosphate pathway" EXACT [] synonym: "pentose phosphate pathway, oxidative branch" EXACT [] synonym: "pentose phosphate shunt, oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] xref: MetaCyc:OXIDATIVEPENT-PWY xref: MIPS_funcat:02.07.01 is_a: GO:0006740 ! NADPH regeneration is_a: GO:0051156 ! glucose 6-phosphate metabolic process relationship: has_part GO:0004341 ! gluconolactonase activity relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009052 name: pentose-phosphate shunt, non-oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY] synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] xref: MetaCyc:NONOXIPENT-PWY xref: MetaCyc:P21-PWY xref: MIPS_funcat:02.07.03 is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:1901135 ! carbohydrate derivative metabolic process relationship: has_part GO:0004750 ! ribulose-phosphate 3-epimerase activity relationship: has_part GO:0004751 ! ribose-5-phosphate isomerase activity relationship: has_part GO:0004801 ! sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity relationship: has_part GO:0004802 ! transketolase activity relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009055 name: electron transfer activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transporter activity" RELATED [] xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" xref: Reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF" xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold" is_a: GO:0016491 ! oxidoreductase activity intersection_of: GO:0016491 ! oxidoreductase activity intersection_of: part_of GO:0022900 ! electron transport chain relationship: part_of GO:0022900 ! electron transport chain [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] synonym: "multicellular organismal catabolic process" NARROW [] synonym: "single-organism catabolic process" RELATED [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 alt_id: GO:0044266 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009060 name: aerobic respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] xref: MetaCyc:PWY-3781 xref: MIPS_funcat:02.13.03 xref: Wikipedia:Cellular_respiration#Aerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009061 name: anaerobic respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] xref: MetaCyc:ANARESP1-PWY xref: MIPS_funcat:02.13.01 xref: Wikipedia:Anaerobic_respiration xref: Wikipedia:Cellular_respiration#Anaerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009062 name: fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] synonym: "fatty acid breakdown" EXACT [] synonym: "fatty acid catabolism" EXACT [] synonym: "fatty acid degradation" EXACT [] xref: MIPS_funcat:01.06.04 xref: MIPS_funcat:01.06.04.05 xref: Wikipedia:Fatty_acid_degradation is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009063 name: cellular amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid catabolic process" EXACT [] synonym: "cellular amino acid breakdown" EXACT [] synonym: "cellular amino acid catabolism" EXACT [] synonym: "cellular amino acid degradation" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01.03 is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009066 name: aspartate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01.06 is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009068 name: aspartate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid breakdown" EXACT [] synonym: "aspartate family amino acid catabolism" EXACT [] synonym: "aspartate family amino acid degradation" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01.09 is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009071 name: serine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid breakdown" EXACT [] synonym: "serine family amino acid catabolism" EXACT [] synonym: "serine family amino acid degradation" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009072 name: aromatic amino acid family metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family metabolism" EXACT [] xref: MIPS_funcat:01.01.09 is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009073 name: aromatic amino acid family biosynthetic process namespace: biological_process alt_id: GO:0016089 def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family anabolism" EXACT [] synonym: "aromatic amino acid family biosynthesis" EXACT [] synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] synonym: "aromatic amino acid family formation" EXACT [] synonym: "aromatic amino acid family synthesis" EXACT [] xref: MetaCyc:COMPLETE-ARO-PWY is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009074 name: aromatic amino acid family catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family breakdown" EXACT [] synonym: "aromatic amino acid family catabolism" EXACT [] synonym: "aromatic amino acid family degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0009075 name: obsolete histidine family amino acid metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid metabolic process" EXACT [] synonym: "histidine family amino acid metabolism" EXACT [] is_obsolete: true replaced_by: GO:0006547 [Term] id: GO:0009076 name: obsolete histidine family amino acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid anabolism" EXACT [] synonym: "histidine family amino acid biosynthesis" EXACT [] synonym: "histidine family amino acid biosynthetic process" EXACT [] synonym: "histidine family amino acid formation" EXACT [] synonym: "histidine family amino acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0000105 [Term] id: GO:0009077 name: obsolete histidine family amino acid catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid breakdown" EXACT [] synonym: "histidine family amino acid catabolic process" EXACT [] synonym: "histidine family amino acid catabolism" EXACT [] synonym: "histidine family amino acid degradation" EXACT [] is_obsolete: true replaced_by: GO:0006548 [Term] id: GO:0009078 name: pyruvate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid metabolism" EXACT [] xref: MIPS_funcat:01.01.11 is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009079 name: pyruvate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid anabolism" EXACT [] synonym: "pyruvate family amino acid biosynthesis" EXACT [] synonym: "pyruvate family amino acid formation" EXACT [] synonym: "pyruvate family amino acid synthesis" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009080 name: pyruvate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid breakdown" EXACT [] synonym: "pyruvate family amino acid catabolism" EXACT [] synonym: "pyruvate family amino acid degradation" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009081 name: branched-chain amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] synonym: "branched chain family amino acid metabolism" EXACT [GOC:ai] xref: MIPS_funcat:01.01.11 is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009082 name: branched-chain amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] synonym: "branched chain family amino acid anabolism" EXACT [] synonym: "branched chain family amino acid biosynthesis" EXACT [] synonym: "branched chain family amino acid biosynthetic process" EXACT [GOC:ai] synonym: "branched chain family amino acid formation" EXACT [] synonym: "branched chain family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009081 ! branched-chain amino acid metabolic process [Term] id: GO:0009083 name: branched-chain amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] synonym: "branched chain family amino acid breakdown" EXACT [] synonym: "branched chain family amino acid catabolic process" EXACT [GOC:ai] synonym: "branched chain family amino acid catabolism" EXACT [] synonym: "branched chain family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009081 ! branched-chain amino acid metabolic process [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:PWY-5097 xref: MIPS_funcat:01.01.06.06.01 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009086 name: methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine anabolism" EXACT [] synonym: "methionine biosynthesis" EXACT [] synonym: "methionine formation" EXACT [] synonym: "methionine synthesis" EXACT [] xref: MIPS_funcat:01.01.06.05.01 is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009087 name: methionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine breakdown" EXACT [] synonym: "methionine catabolism" EXACT [] synonym: "methionine degradation" EXACT [] xref: MIPS_funcat:01.01.06.05.02 xref: UM-BBD_pathwayID:met is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0009088 name: threonine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "threonine anabolism" EXACT [] synonym: "threonine biosynthesis" EXACT [] synonym: "threonine formation" EXACT [] synonym: "threonine synthesis" EXACT [] xref: MetaCyc:HOMOSER-THRESYN-PWY xref: MetaCyc:THRESYN-PWY xref: MIPS_funcat:01.01.06.04.01 is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009089 name: lysine biosynthetic process via diaminopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] synonym: "diaminopimelate pathway" EXACT [] synonym: "diaminopimelic acid pathway" EXACT [] synonym: "lysine anabolism via diaminopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] synonym: "lysine formation via diaminopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate" EXACT [] xref: MIPS_funcat:01.01.06.06.01.01 is_a: GO:0009085 ! lysine biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0009090 name: homoserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine anabolism" EXACT [] synonym: "homoserine biosynthesis" EXACT [] synonym: "homoserine formation" EXACT [] synonym: "homoserine synthesis" EXACT [] xref: MetaCyc:HOMOSERSYN-PWY is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009091 name: homoserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine breakdown" EXACT [] synonym: "homoserine catabolism" EXACT [] synonym: "homoserine degradation" EXACT [] xref: MetaCyc:HOMOCYSDEGR-PWY is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009092 name: homoserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009093 name: cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine breakdown" EXACT [] synonym: "cysteine catabolism" EXACT [] synonym: "cysteine degradation" EXACT [] xref: MIPS_funcat:01.01.09.03.02 xref: Wikipedia:Cysteine is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0009094 name: L-phenylalanine biosynthetic process namespace: biological_process alt_id: GO:0019274 alt_id: GO:0019275 def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah] synonym: "L-phenylalanine anabolism" EXACT [] synonym: "L-phenylalanine biosynthesis" EXACT [] synonym: "L-phenylalanine formation" EXACT [] synonym: "L-phenylalanine synthesis" EXACT [] synonym: "phenylalanine biosynthesis" BROAD [] synonym: "phenylalanine biosynthetic process" BROAD [] synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] xref: MIPS_funcat:01.01.09.04.01 is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process [Term] id: GO:0009095 name: aromatic amino acid family biosynthetic process, prephenate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309] synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] synonym: "aromatic amino acid family biosynthetic process via prephenate" EXACT [GOC:pr] synonym: "aromatic amino acid family biosynthetic process via prephenate(2-)" EXACT [GOC:pr] synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process [Term] id: GO:0009097 name: isoleucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine anabolism" EXACT [] synonym: "isoleucine biosynthesis" EXACT [] synonym: "isoleucine formation" EXACT [] synonym: "isoleucine synthesis" EXACT [] xref: MetaCyc:ILEUSYN-PWY xref: MIPS_funcat:01.01.11.02.01 is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009098 name: leucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine anabolism" EXACT [] synonym: "leucine biosynthesis" EXACT [] synonym: "leucine formation" EXACT [] synonym: "leucine synthesis" EXACT [] xref: MetaCyc:LEUSYN-PWY xref: MIPS_funcat:01.01.11.04.01 is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009099 name: valine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine anabolism" EXACT [] synonym: "valine biosynthesis" EXACT [] synonym: "valine formation" EXACT [] synonym: "valine synthesis" EXACT [] xref: MetaCyc:VALSYN-PWY xref: MIPS_funcat:01.01.11.03.01 is_a: GO:0006573 ! valine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process relationship: has_part GO:0003984 ! acetolactate synthase activity relationship: has_part GO:0004160 ! dihydroxy-acid dehydratase activity relationship: has_part GO:0004455 ! ketol-acid reductoisomerase activity relationship: has_part GO:0052655 ! L-valine transaminase activity [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009102 name: biotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] synonym: "biotin anabolism" EXACT [] synonym: "biotin biosynthesis" EXACT [] synonym: "biotin formation" EXACT [] synonym: "biotin synthesis" EXACT [] synonym: "vitamin B7 biosynthesis" EXACT [] synonym: "vitamin B7 biosynthetic process" EXACT [] synonym: "vitamin H biosynthesis" EXACT [] synonym: "vitamin H biosynthetic process" EXACT [] xref: MetaCyc:BIOTIN-SYNTHESIS-PWY is_a: GO:0006768 ! biotin metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009103 name: lipopolysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] synonym: "lipopolysaccharide anabolism" EXACT [] synonym: "lipopolysaccharide biosynthesis" EXACT [] synonym: "lipopolysaccharide formation" EXACT [] synonym: "lipopolysaccharide synthesis" EXACT [] synonym: "LPS biosynthetic process" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009104 name: lipopolysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] synonym: "lipopolysaccharide breakdown" EXACT [] synonym: "lipopolysaccharide catabolism" EXACT [] synonym: "lipopolysaccharide degradation" EXACT [] synonym: "LPS catabolic process" EXACT [] is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009106 name: lipoate metabolic process namespace: biological_process alt_id: GO:0000273 def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] synonym: "lipoate metabolism" EXACT [] synonym: "lipoic acid metabolic process" EXACT [] synonym: "lipoic acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009107 name: lipoate biosynthetic process namespace: biological_process alt_id: GO:0009105 def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] synonym: "lipoate anabolism" EXACT [] synonym: "lipoate biosynthesis" EXACT [] synonym: "lipoate formation" EXACT [] synonym: "lipoate synthesis" EXACT [] synonym: "lipoic acid anabolism" EXACT [] synonym: "lipoic acid biosynthesis" EXACT [] synonym: "lipoic acid biosynthetic process" EXACT [] synonym: "lipoic acid formation" EXACT [] synonym: "lipoic acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009108 name: coenzyme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009109 name: coenzyme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "coenzyme breakdown" EXACT [] synonym: "coenzyme catabolism" EXACT [] synonym: "coenzyme degradation" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0009110 name: vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732] synonym: "vitamin anabolism" EXACT [] synonym: "vitamin biosynthesis" EXACT [] synonym: "vitamin formation" EXACT [] synonym: "vitamin synthesis" EXACT [] xref: MIPS_funcat:01.07.01 is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0009111 name: vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "vitamin breakdown" EXACT [] synonym: "vitamin catabolism" EXACT [] synonym: "vitamin degradation" EXACT [] xref: MIPS_funcat:01.07.03 is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009113 name: purine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732] synonym: "purine base anabolism" EXACT [] synonym: "purine base biosynthesis" EXACT [] synonym: "purine base biosynthetic process" EXACT [GOC:go_curators] synonym: "purine base formation" EXACT [] synonym: "purine base synthesis" EXACT [] xref: MetaCyc:PWY-841 is_a: GO:0006144 ! purine nucleobase metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0009114 name: hypoxanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] synonym: "hypoxanthine breakdown" EXACT [] synonym: "hypoxanthine catabolism" EXACT [] synonym: "hypoxanthine degradation" EXACT [] xref: MIPS_funcat:01.03.01.01.01 is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0009115 name: xanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] synonym: "xanthine breakdown" EXACT [] synonym: "xanthine catabolism" EXACT [] synonym: "xanthine degradation" EXACT [] xref: MIPS_funcat:01.03.01.01.03 is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir synonym: "nucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03 is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009118 name: regulation of nucleoside metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "regulation of nucleoside metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009116 ! nucleoside metabolic process relationship: regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009120 name: deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009125 name: nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate breakdown" EXACT [] synonym: "nucleoside monophosphate catabolism" EXACT [] synonym: "nucleoside monophosphate degradation" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009128 name: purine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate breakdown" EXACT [] synonym: "purine nucleoside monophosphate catabolism" EXACT [] synonym: "purine nucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009129 name: pyrimidine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009130 name: pyrimidine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009131 name: pyrimidine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009133 name: nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate anabolism" EXACT [] synonym: "nucleoside diphosphate biosynthesis" EXACT [] synonym: "nucleoside diphosphate formation" EXACT [] synonym: "nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009134 name: nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate breakdown" EXACT [] synonym: "nucleoside diphosphate catabolism" EXACT [] synonym: "nucleoside diphosphate degradation" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009135 name: purine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009136 name: purine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate anabolism" EXACT [] synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] synonym: "purine nucleoside diphosphate formation" EXACT [] synonym: "purine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009137 name: purine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate breakdown" EXACT [] synonym: "purine nucleoside diphosphate catabolism" EXACT [] synonym: "purine nucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009138 name: pyrimidine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009139 name: pyrimidine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009140 name: pyrimidine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009143 name: nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate breakdown" EXACT [] synonym: "nucleoside triphosphate catabolism" EXACT [] synonym: "nucleoside triphosphate degradation" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009146 name: purine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate breakdown" EXACT [] synonym: "purine nucleoside triphosphate catabolism" EXACT [] synonym: "purine nucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009147 name: pyrimidine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009148 name: pyrimidine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009149 name: pyrimidine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009151 name: purine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009153 name: purine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide anabolism" EXACT [] synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] synonym: "purine deoxyribonucleotide formation" EXACT [] synonym: "purine deoxyribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009154 name: purine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide breakdown" EXACT [] synonym: "purine ribonucleotide catabolism" EXACT [] synonym: "purine ribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009155 name: purine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide breakdown" EXACT [] synonym: "purine deoxyribonucleotide catabolism" EXACT [] synonym: "purine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009157 name: deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside monophosphate formation" EXACT [] synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009158 name: ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate breakdown" EXACT [] synonym: "ribonucleoside monophosphate catabolism" EXACT [] synonym: "ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009159 name: deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009162 name: deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0009164 name: nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] synonym: "nucleoside breakdown" EXACT [] synonym: "nucleoside catabolism" EXACT [] synonym: "nucleoside degradation" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009166 name: nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide breakdown" EXACT [] synonym: "nucleotide catabolism" EXACT [] synonym: "nucleotide degradation" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009169 name: purine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] synonym: "purine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009170 name: purine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009171 name: purine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009172 name: purine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009173 name: pyrimidine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009174 name: pyrimidine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process [Term] id: GO:0009175 name: pyrimidine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process [Term] id: GO:0009176 name: pyrimidine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009177 name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009178 name: pyrimidine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009180 name: purine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside diphosphate formation" EXACT [] synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process [Term] id: GO:0009181 name: purine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] synonym: "purine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process [Term] id: GO:0009182 name: purine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009183 name: purine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process [Term] id: GO:0009184 name: purine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process [Term] id: GO:0009185 name: ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009186 name: deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009187 name: cyclic nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03.10 is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009188 name: ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate anabolism" EXACT [] synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "ribonucleoside diphosphate formation" EXACT [] synonym: "ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009189 name: deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside diphosphate formation" EXACT [] synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009190 name: cyclic nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide anabolism" EXACT [] synonym: "cyclic nucleotide biosynthesis" EXACT [] synonym: "cyclic nucleotide formation" EXACT [] synonym: "cyclic nucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009191 name: ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate breakdown" EXACT [] synonym: "ribonucleoside diphosphate catabolism" EXACT [] synonym: "ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009192 name: deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009193 name: pyrimidine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009194 name: pyrimidine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0009195 name: pyrimidine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0009196 name: pyrimidine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009197 name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009198 name: pyrimidine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009200 name: deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009202 name: deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside triphosphate formation" EXACT [] synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009203 name: ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate breakdown" EXACT [] synonym: "ribonucleoside triphosphate catabolism" EXACT [] synonym: "ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009204 name: deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009207 name: purine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] synonym: "purine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009208 name: pyrimidine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009209 name: pyrimidine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process [Term] id: GO:0009210 name: pyrimidine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process [Term] id: GO:0009211 name: pyrimidine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009212 name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009213 name: pyrimidine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009214 name: cyclic nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide breakdown" EXACT [] synonym: "cyclic nucleotide catabolism" EXACT [] synonym: "cyclic nucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009215 name: purine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009216 name: purine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009217 name: purine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009218 name: pyrimidine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009219 name: pyrimidine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009220 name: pyrimidine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide anabolism" EXACT [] synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine ribonucleotide formation" EXACT [] synonym: "pyrimidine ribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-162 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009221 name: pyrimidine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-166 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009222 name: pyrimidine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide breakdown" EXACT [] synonym: "pyrimidine ribonucleotide catabolism" EXACT [] synonym: "pyrimidine ribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009223 name: pyrimidine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0009224 name: CMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732] synonym: "CMP anabolism" EXACT [] synonym: "CMP biosynthesis" EXACT [] synonym: "CMP formation" EXACT [] synonym: "CMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0009225 name: nucleotide-sugar metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] comment: Added parent as requested here https://github.com/geneontology/go-ontology/issues/14587 subset: goslim_pir synonym: "nucleotide-sugar metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009226 name: nucleotide-sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar anabolism" EXACT [] synonym: "nucleotide-sugar biosynthesis" EXACT [] synonym: "nucleotide-sugar formation" EXACT [] synonym: "nucleotide-sugar synthesis" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009227 name: nucleotide-sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar breakdown" EXACT [] synonym: "nucleotide-sugar catabolism" EXACT [] synonym: "nucleotide-sugar degradation" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009228 name: thiamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] synonym: "thiamin anabolism" EXACT [] synonym: "thiamin biosynthetic process" EXACT [] synonym: "thiamine biosynthesis" EXACT [] synonym: "thiamine formation" EXACT [] synonym: "thiamine synthesis" EXACT [] synonym: "vitamin B1 biosynthesis" EXACT [] synonym: "vitamin B1 biosynthetic process" EXACT [] xref: MetaCyc:THISYN-PWY is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042724 ! thiamine-containing compound biosynthetic process [Term] id: GO:0009229 name: thiamine diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713] synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators] synonym: "thiamin pyrophosphate biosynthesis" EXACT [] synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] synonym: "thiamine diphosphate anabolism" EXACT [] synonym: "thiamine diphosphate biosynthesis" EXACT [] synonym: "thiamine diphosphate formation" EXACT [] synonym: "thiamine diphosphate synthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] synonym: "TPP biosynthesis" EXACT [] synonym: "TPP biosynthetic process" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0009230 name: thiamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] synonym: "thiamin catabolic process" EXACT [] synonym: "thiamine breakdown" EXACT [] synonym: "thiamine catabolism" EXACT [] synonym: "thiamine degradation" EXACT [] synonym: "vitamin B1 catabolic process" EXACT [] synonym: "vitamin B1 catabolism" EXACT [] is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042725 ! thiamine-containing compound catabolic process [Term] id: GO:0009231 name: riboflavin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin anabolism" EXACT [] synonym: "riboflavin biosynthesis" EXACT [] synonym: "riboflavin formation" EXACT [] synonym: "riboflavin synthesis" EXACT [] synonym: "vitamin B2 biosynthesis" EXACT [] synonym: "vitamin B2 biosynthetic process" EXACT [] synonym: "vitamin G biosynthesis" EXACT [] synonym: "vitamin G biosynthetic process" EXACT [] xref: MetaCyc:RIBOSYN2-PWY xref: Wikipedia:Riboflavin is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process [Term] id: GO:0009232 name: riboflavin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin breakdown" EXACT [] synonym: "riboflavin catabolism" EXACT [] synonym: "riboflavin degradation" EXACT [] synonym: "vitamin B2 catabolic process" EXACT [] synonym: "vitamin B2 catabolism" EXACT [] synonym: "vitamin G catabolic process" EXACT [] synonym: "vitamin G catabolism" EXACT [] is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0009233 name: menaquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "menaquinone metabolism" EXACT [] synonym: "menatetrenone metabolic process" EXACT [] synonym: "menatetrenone metabolism" EXACT [] synonym: "multiprenylmenaquinone metabolic process" EXACT [] synonym: "multiprenylmenaquinone metabolism" EXACT [] synonym: "vitamin K2 metabolic process" EXACT [] synonym: "vitamin K2 metabolism" EXACT [] is_a: GO:1901661 ! quinone metabolic process [Term] id: GO:0009234 name: menaquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "menaquinone anabolism" EXACT [] synonym: "menaquinone biosynthesis" EXACT [] synonym: "menaquinone formation" EXACT [] synonym: "menaquinone synthesis" EXACT [] synonym: "menatetrenone biosynthesis" EXACT [] synonym: "menatetrenone biosynthetic process" EXACT [] synonym: "multiprenylmenaquinone biosynthesis" EXACT [] synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K2 biosynthesis" EXACT [] synonym: "vitamin K2 biosynthetic process" EXACT [] xref: MetaCyc:MENAQUINONESYN-PWY is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0009235 name: cobalamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] synonym: "cobalamin metabolism" EXACT [] synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009236 name: cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732] synonym: "cobalamin anabolism" EXACT [] synonym: "cobalamin biosynthesis" EXACT [] synonym: "cobalamin formation" EXACT [] synonym: "cobalamin synthesis" EXACT [] synonym: "vitamin B12 biosynthesis" EXACT [] synonym: "vitamin B12 biosynthetic process" EXACT [] xref: MIPS_funcat:01.20.19.05 is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009237 name: siderophore metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] synonym: "siderochrome metabolic process" NARROW [] synonym: "siderochrome metabolism" NARROW [] synonym: "siderophore metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009238 name: enterobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] synonym: "enterobactin metabolism" EXACT [] synonym: "enterochelin metabolic process" EXACT [] synonym: "enterochelin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009239 name: enterobactin biosynthetic process namespace: biological_process alt_id: GO:0031191 alt_id: GO:0031192 def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] synonym: "enterobactin anabolism" EXACT [] synonym: "enterobactin biosynthesis" EXACT [] synonym: "enterobactin biosynthetic process, peptide formation" NARROW [] synonym: "enterobactin biosynthetic process, peptide modification" NARROW [] synonym: "enterobactin formation" EXACT [] synonym: "enterobactin synthesis" EXACT [] synonym: "enterobactin synthetase" RELATED [] synonym: "enterochelin biosynthesis" EXACT [] synonym: "enterochelin biosynthetic process" EXACT [] xref: MetaCyc:ENTBACSYN-PWY is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol [Term] id: GO:0009240 name: isopentenyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732] synonym: "IPP biosynthesis" EXACT [] synonym: "IPP biosynthetic process" EXACT [] synonym: "isopentenyl diphosphate anabolism" EXACT [] synonym: "isopentenyl diphosphate biosynthesis" EXACT [] synonym: "isopentenyl diphosphate formation" EXACT [] synonym: "isopentenyl diphosphate synthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046490 ! isopentenyl diphosphate metabolic process relationship: part_of GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0009242 name: colanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] synonym: "colanic acid anabolism" EXACT [] synonym: "colanic acid biosynthesis" EXACT [] synonym: "colanic acid formation" EXACT [] synonym: "colanic acid synthesis" EXACT [] synonym: "M antigen biosynthesis" EXACT [] synonym: "M antigen biosynthetic process" EXACT [] xref: MetaCyc:COLANSYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046377 ! colanic acid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009243 name: O antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732] synonym: "O antigen anabolism" EXACT [] synonym: "O antigen biosynthesis" EXACT [] synonym: "O antigen formation" EXACT [] synonym: "O antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046402 ! O antigen metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009244 name: lipopolysaccharide core region biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732] synonym: "lipopolysaccharide core region anabolism" EXACT [] synonym: "lipopolysaccharide core region biosynthesis" EXACT [] synonym: "lipopolysaccharide core region formation" EXACT [] synonym: "lipopolysaccharide core region synthesis" EXACT [] synonym: "LPS core region biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0046401 ! lipopolysaccharide core region metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009245 name: lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004] synonym: "lipid A anabolism" EXACT [] synonym: "lipid A biosynthesis" EXACT [] synonym: "lipid A formation" EXACT [] synonym: "lipid A synthesis" EXACT [] xref: MetaCyc:NAGLIPASYN-PWY is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0046493 ! lipid A metabolic process is_a: GO:1901271 ! lipooligosaccharide biosynthetic process [Term] id: GO:0009246 name: enterobacterial common antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] synonym: "enterobacterial common antigen anabolism" EXACT [] synonym: "enterobacterial common antigen biosynthesis" EXACT [] synonym: "enterobacterial common antigen formation" EXACT [] synonym: "enterobacterial common antigen synthesis" EXACT [] xref: MetaCyc:ECASYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046378 ! enterobacterial common antigen metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009247 name: glycolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] synonym: "glycolipid anabolism" EXACT [] synonym: "glycolipid biosynthesis" EXACT [] synonym: "glycolipid formation" EXACT [] synonym: "glycolipid synthesis" EXACT [] xref: MetaCyc:PWY-401 xref: MIPS_funcat:01.06.01.03 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009248 name: K antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732] synonym: "K antigen anabolism" EXACT [] synonym: "K antigen biosynthesis" EXACT [] synonym: "K antigen formation" EXACT [] synonym: "K antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046375 ! K antigen metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009249 name: protein lipoylation namespace: biological_process alt_id: GO:0018055 def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] synonym: "peptidyl-lysine lipoylation" EXACT [] synonym: "protein-lipoic acid cofactor linkage" EXACT [] is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0009252 name: peptidoglycan biosynthetic process namespace: biological_process alt_id: GO:0009285 def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein biosynthesis" EXACT [] synonym: "murein biosynthetic process" EXACT [] synonym: "peptidoglycan anabolism" EXACT [] synonym: "peptidoglycan biosynthesis" EXACT [] synonym: "peptidoglycan formation" EXACT [] synonym: "peptidoglycan synthesis" EXACT [] xref: MIPS_funcat:01.05.01.03.02.02 is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0009253 name: peptidoglycan catabolic process namespace: biological_process alt_id: GO:0009286 def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein catabolic process" EXACT [] synonym: "murein catabolism" EXACT [] synonym: "peptidoglycan breakdown" EXACT [] synonym: "peptidoglycan catabolism" EXACT [] synonym: "peptidoglycan degradation" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006027 ! glycosaminoglycan catabolic process [Term] id: GO:0009254 name: peptidoglycan turnover namespace: biological_process alt_id: GO:0009287 def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] synonym: "murein turnover" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process [Term] id: GO:0009255 name: Entner-Doudoroff pathway through 6-phosphogluconate namespace: biological_process def: "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY-I, PMID:12921356] xref: MetaCyc:ENTNER-DOUDOROFF-PWY-I xref: MIPS_funcat:02.05 xref: PMID:12981024 is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0061678 ! Entner-Doudoroff pathway relationship: has_part GO:0004456 ! phosphogluconate dehydratase activity [Term] id: GO:0009256 name: 10-formyltetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF metabolic process" EXACT [] synonym: "10-formyl-THF metabolism" EXACT [] synonym: "10-formyltetrahydrofolate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0009257 name: 10-formyltetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF biosynthesis" EXACT [] synonym: "10-formyl-THF biosynthetic process" EXACT [] synonym: "10-formyltetrahydrofolate anabolism" EXACT [] synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] synonym: "10-formyltetrahydrofolate formation" EXACT [] synonym: "10-formyltetrahydrofolate synthesis" EXACT [] xref: MetaCyc:1CMET2-PWY xref: MetaCyc:PWY-3841 is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046654 ! tetrahydrofolate biosynthetic process [Term] id: GO:0009258 name: 10-formyltetrahydrofolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF catabolic process" EXACT [] synonym: "10-formyl-THF catabolism" EXACT [] synonym: "10-formyltetrahydrofolate breakdown" EXACT [] synonym: "10-formyltetrahydrofolate catabolism" EXACT [] synonym: "10-formyltetrahydrofolate degradation" EXACT [] is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0009397 ! folic acid-containing compound catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0046390 ! ribose phosphate biosynthetic process [Term] id: GO:0009261 name: ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide breakdown" EXACT [] synonym: "ribonucleotide catabolism" EXACT [] synonym: "ribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009262 name: deoxyribonucleotide metabolic process namespace: biological_process alt_id: GO:0009122 alt_id: GO:0009393 def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide metabolism" EXACT [] xref: MIPS_funcat:01.03.07 is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009263 name: deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide anabolism" EXACT [] synonym: "deoxyribonucleotide biosynthesis" EXACT [] synonym: "deoxyribonucleotide formation" EXACT [] synonym: "deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009264 name: deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide breakdown" EXACT [] synonym: "deoxyribonucleotide catabolism" EXACT [] synonym: "deoxyribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009265 name: 2'-deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] synonym: "2'-deoxyribonucleotide anabolism" EXACT [] synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] synonym: "2'-deoxyribonucleotide formation" EXACT [] synonym: "2'-deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] synonym: "response to thermal stimulus" EXACT [] xref: MIPS_funcat:34.11.09 is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, http://en.wikipedia.org/wiki/PH] xref: MIPS_funcat:32.01.04 xref: MIPS_funcat:34.11.03.11 xref: MIPS_funcat:36.20.35.09.03 is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009269 name: response to desiccation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] synonym: "desiccation tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009270 name: response to humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] is_a: GO:0009415 ! response to water [Term] id: GO:0009271 name: phage shock namespace: biological_process def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] is_a: GO:0006950 ! response to stress is_a: GO:0098586 ! cellular response to virus [Term] id: GO:0009272 name: fungal-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah] synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah] synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0009273 name: peptidoglycan-based cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators] synonym: "cell envelope biosynthesis" BROAD [] synonym: "cell envelope biosynthetic process" BROAD [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0042546 ! cell wall biogenesis [Term] id: GO:0009274 name: peptidoglycan-based cell wall namespace: cellular_component def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893] synonym: "envelope" BROAD [] synonym: "murein sacculus" RELATED [] synonym: "peptidoglycan" NARROW [] xref: MIPS_funcat:42.34.07 xref: MIPS_funcat:70.34.07 is_a: GO:0005618 ! cell wall [Term] id: GO:0009275 name: Gram-positive-bacterium-type cell wall namespace: cellular_component def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0815108893] synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall of Gram-positive Bacteria" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall [Term] id: GO:0009276 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] subset: goslim_metagenomics synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall inner membrane" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009278 name: obsolete murein sacculus namespace: cellular_component def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "murein sacculus" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009279 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254] comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886. synonym: "outer membrane of cell" EXACT [] xref: MIPS_funcat:70.34.01 is_a: GO:0019867 ! outer membrane intersection_of: GO:0019867 ! outer membrane intersection_of: part_of GO:0030313 ! cell envelope relationship: part_of GO:0030312 ! external encapsulating structure relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009280 name: obsolete cell wall inner membrane namespace: cellular_component def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "cell wall inner membrane" EXACT [] synonym: "cytoplasmic membrane" BROAD [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009288 name: bacterial-type flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] subset: goslim_metagenomics subset: goslim_pir synonym: "flagellin-based flagellum" EXACT [] is_a: GO:0042995 ! cell projection is_a: GO:0043228 ! non-membrane-bounded organelle [Term] id: GO:0009289 name: pilus namespace: cellular_component def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] subset: goslim_pir synonym: "fimbria" EXACT [] synonym: "fimbriae" EXACT [] synonym: "fimbrium" EXACT [] synonym: "pili" EXACT [] xref: MIPS_funcat:70.33 xref: Wikipedia:Pilus is_a: GO:0042995 ! cell projection [Term] id: GO:0009290 name: DNA import into cell involved in transformation namespace: biological_process def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] synonym: "cellular DNA import during transformation" RELATED [] synonym: "cellular DNA uptake" BROAD [] synonym: "DNA import into cell" BROAD [] synonym: "DNA import into cell involved in transformation" RELATED [GOC:dph, GOC:tb] synonym: "DNA transport into cell during transformation" RELATED [] xref: MIPS_funcat:10.01.01 is_a: GO:0051027 ! DNA transport is_a: GO:0098657 ! import into cell relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0009291 name: unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546] xref: MIPS_funcat:10.01.01.03 is_a: GO:0000746 ! conjugation is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009292 name: genetic transfer namespace: biological_process def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] comment: GO:0009292 should not be used for annotation of phage lysogeny (integration of the bacteriophage nucleic acid into the host bacterium's genome). subset: goslim_pir synonym: "genetic exchange" BROAD [] is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0009293 name: transduction namespace: biological_process def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732] xref: Wikipedia:Transduction_(genetics) is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009294 name: DNA mediated transformation namespace: biological_process def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)] synonym: "DNA-mediated transformation" EXACT [] is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] xref: Wikipedia:Nucleoid is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0009296 name: obsolete flagellum assembly namespace: biological_process def: "OBSOLETE. The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194] synonym: "flagella assembly" EXACT [GOC:mah] synonym: "flagella biogenesis" RELATED [] synonym: "flagellum assembly" EXACT [] synonym: "flagellum biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.32 is_obsolete: true consider: GO:0044780 consider: GO:0060271 [Term] id: GO:0009297 name: pilus assembly namespace: biological_process def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb] synonym: "fimbria assembly" NARROW [] synonym: "fimbria biogenesis" RELATED [] synonym: "fimbriae assembly" NARROW [] synonym: "fimbriae biogenesis" RELATED [] synonym: "fimbrial assembly" NARROW [] synonym: "fimbrial biogenesis" NARROW [] synonym: "fimbrium assembly" NARROW [] synonym: "fimbrium biogenesis" RELATED [] synonym: "pili biosynthesis" EXACT [] synonym: "pili biosynthetic process" EXACT [] synonym: "pilus biogenesis" RELATED [] synonym: "pilus biosynthesis" EXACT [] synonym: "pilus formation" EXACT [GOC:dph, GOC:tb] xref: MIPS_funcat:42.33 is_a: GO:0030031 ! cell projection assembly is_a: GO:0043711 ! pilus organization [Term] id: GO:0009298 name: GDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-mannose anabolism" EXACT [] synonym: "GDP-mannose biosynthesis" EXACT [] synonym: "GDP-mannose formation" EXACT [] synonym: "GDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019673 ! GDP-mannose metabolic process relationship: has_part GO:0004615 ! phosphomannomutase activity [Term] id: GO:0009299 name: mRNA transcription namespace: biological_process alt_id: GO:0061023 def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] synonym: "cellular mRNA transcription" EXACT [] synonym: "mRNA biosynthesis" BROAD [] synonym: "mRNA biosynthetic process" BROAD [] synonym: "mRNA synthesis" BROAD [] xref: MIPS_funcat:11.02.03 is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0009300 name: antisense RNA transcription namespace: biological_process def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl] is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0042868 ! antisense RNA metabolic process [Term] id: GO:0009301 name: snRNA transcription namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009302 name: snoRNA transcription namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009303 name: rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] synonym: "rRNA biosynthesis" BROAD [] synonym: "rRNA biosynthetic process" BROAD [] synonym: "rRNA synthesis" BROAD [] xref: MIPS_funcat:11.02.01 is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009304 name: tRNA transcription namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] synonym: "tRNA biosynthesis" BROAD [] synonym: "tRNA biosynthetic process" BROAD [] synonym: "tRNA synthesis" BROAD [] xref: MIPS_funcat:11.02.02 is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009305 name: protein biotinylation namespace: biological_process def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] synonym: "protein amino acid biotinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] subset: goslim_drosophila synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0002790 ! peptide secretion is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region [Term] id: GO:0009307 name: DNA restriction-modification system namespace: biological_process def: "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680] synonym: "DNA restriction" BROAD [] xref: MIPS_funcat:10.01.09 xref: MIPS_funcat:10.01.09.03 is_a: GO:0006304 ! DNA modification is_a: GO:0044355 ! clearance of foreign intracellular DNA [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] xref: MIPS_funcat:01.20.17.03 is_a: GO:0009308 ! amine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009311 name: oligosaccharide metabolic process namespace: biological_process alt_id: GO:0051690 def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] subset: goslim_yeast synonym: "multicellular organismal oligosaccharide metabolic process" NARROW [] synonym: "oligosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0009312 name: oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] synonym: "oligosaccharide anabolism" EXACT [] synonym: "oligosaccharide biosynthesis" EXACT [] synonym: "oligosaccharide formation" EXACT [] synonym: "oligosaccharide synthesis" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0009313 name: oligosaccharide catabolic process namespace: biological_process alt_id: GO:0051689 def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] synonym: "multicellular organismal oligosaccharide catabolic process" NARROW [] synonym: "oligosaccharide breakdown" EXACT [] synonym: "oligosaccharide catabolism" EXACT [] synonym: "oligosaccharide degradation" EXACT [] xref: MIPS_funcat:01.05.01.01.01 is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] xref: MIPS_funcat:32.01.13 is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009315 name: obsolete drug resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "drug resistance" EXACT [] is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0009316 name: 3-isopropylmalate dehydratase complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530] comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. synonym: "isopropylmalate isomerase complex" EXACT [] xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0009317 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] subset: goslim_metagenomics subset: goslim_pir synonym: "ACCase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009318 name: exodeoxyribonuclease VII complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009319 name: cytochrome o ubiquinol oxidase complex namespace: cellular_component def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268] comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. xref: MetaCyc:CYT-O-UBIOX-CPLX is_a: GO:0070069 ! cytochrome complex is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0009320 name: phosphoribosylaminoimidazole carboxylase complex namespace: cellular_component def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009321 name: alkyl hydroperoxide reductase complex namespace: cellular_component def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [GOC:jl, PMID:2649484] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009322 name: trimethylamine-N-oxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [GOC:curators] is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009323 name: ribosomal-protein-alanine N-acetyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] xref: EC:2.3.1.128 xref: RHEA:43752 is_a: GO:0031248 ! protein acetyltransferase complex [Term] id: GO:0009324 name: D-amino-acid dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009325 name: nitrate reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009326 name: formate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.17.1.9] xref: EC:1.17.1.9 is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009327 name: NAD(P)+ transhydrogenase complex (AB-specific) namespace: cellular_component def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009328 name: phenylalanine-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009329 name: acetate CoA-transferase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009330 name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex namespace: cellular_component def: "Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:Type_II_topoisomerase] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009331 name: glycerol-3-phosphate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009332 name: glutamate-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009333 name: cysteine synthase complex namespace: cellular_component def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009334 name: 3-phenylpropionate dioxygenase complex namespace: cellular_component def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882] comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. xref: MetaCyc:HCAMULTI-CPLX is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009335 name: obsolete holo-[acyl-carrier protein] synthase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. synonym: "holo-[acyl-carrier protein] synthase complex" EXACT [] synonym: "holo-ACP synthase complex" EXACT [] is_obsolete: true consider: GO:0005835 [Term] id: GO:0009336 name: sulfate adenylyltransferase complex (ATP) namespace: cellular_component def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] is_a: GO:1902503 ! adenylyltransferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009337 name: sulfite reductase complex (NADPH) namespace: cellular_component def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl] comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. synonym: "sulphite reductase complex (NADPH)" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009338 name: exodeoxyribonuclease V complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009339 name: glycolate oxidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009340 name: DNA topoisomerase IV complex namespace: cellular_component def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632] is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009341 name: beta-galactosidase complex namespace: cellular_component def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161] subset: goslim_metagenomics is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009342 name: glutamate synthase complex (NADPH) namespace: cellular_component def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0009343 name: biotin carboxylase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009344 name: nitrite reductase complex [NAD(P)H] namespace: cellular_component def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0009345 name: glycine-tRNA ligase complex namespace: cellular_component def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854] synonym: "glycine-tRNA synthetase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009346 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009347 name: aspartate carbamoyltransferase complex namespace: cellular_component def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. is_a: GO:1990234 ! transferase complex [Term] id: GO:0009348 name: ornithine carbamoyltransferase complex namespace: cellular_component def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009349 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: goslim_metagenomics is_a: GO:1990234 ! transferase complex [Term] id: GO:0009350 name: ethanolamine ammonia-lyase complex namespace: cellular_component def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009351 name: obsolete dihydrolipoamide S-acyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. synonym: "dihydrolipoamide S-acyltransferase complex" EXACT [] is_obsolete: true [Term] id: GO:0009352 name: obsolete dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] synonym: "dihydrolipoyl dehydrogenase complex" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0045240 consider: GO:0045254 [Term] id: GO:0009353 name: mitochondrial oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. is_a: GO:0005947 ! mitochondrial alpha-ketoglutarate dehydrogenase complex is_a: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0009354 name: obsolete dihydrolipoamide S-succinyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] is_obsolete: true consider: GO:0045252 [Term] id: GO:0009355 name: DNA polymerase V complex namespace: cellular_component def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009356 name: aminodeoxychorismate synthase complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] synonym: "ADC synthase complex" EXACT [] synonym: "p-aminobenzoate synthetase complex" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009357 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups is_a: GO:1902495 ! transmembrane transporter complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009358 name: polyphosphate kinase complex namespace: cellular_component def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0009359 name: type II site-specific deoxyribonuclease complex namespace: cellular_component def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] synonym: "type II restriction enzyme complex" EXACT [] is_a: GO:1905347 ! endodeoxyribonuclease complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009360 name: DNA polymerase III complex namespace: cellular_component def: "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710] synonym: "DNA polymerase III holoenzyme complex" EXACT [] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009361 name: succinate-CoA ligase complex (ADP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394] is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0009365 name: protein histidine kinase complex namespace: cellular_component def: "A complex that possesses protein histidine kinase activity." [GOC:mah] is_a: GO:1902911 ! protein kinase complex [Term] id: GO:0009366 name: enterobactin synthetase complex namespace: cellular_component def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415] synonym: "enterochelin synthetase complex" EXACT [] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009367 name: obsolete prepilin peptidase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer. synonym: "prepilin peptidase complex" EXACT [] is_obsolete: true [Term] id: GO:0009368 name: endopeptidase Clp complex namespace: cellular_component def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009371 name: positive regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by pheromones" NARROW [] synonym: "stimulation of transcription by pheromones" NARROW [] synonym: "up regulation of transcription by pheromones" EXACT [] synonym: "up-regulation of transcription by pheromones" EXACT [] synonym: "upregulation of transcription by pheromones" EXACT [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045893 ! positive regulation of transcription, DNA-templated [Term] id: GO:0009372 name: quorum sensing namespace: biological_process alt_id: GO:0010699 alt_id: GO:0060247 def: "The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms." [GOC:krc, GOC:mlg, PMID:10607620, PMID:15716452, PMID:16497924, PMID:16630813, PMID:8288518] subset: goslim_metagenomics subset: goslim_pir synonym: "cell-cell signaling involved in quorum sensing" RELATED [] synonym: "detection of cell density by secreted molecule" RELATED [] synonym: "quorum sensing system" EXACT [] xref: MIPS_funcat:34.11.03.15 xref: Wikipedia:Quorum_sensing is_a: GO:0007267 ! cell-cell signaling is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0060245 ! detection of cell density [Term] id: GO:0009373 name: regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0071444 ! cellular response to pheromone [Term] id: GO:0009374 name: biotin binding namespace: molecular_function def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732] synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] xref: MIPS_funcat:16.21.15 is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0009375 name: ferredoxin hydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] synonym: "hydrogenase complex" BROAD [] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009376 name: HslUV protease complex namespace: cellular_component def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer." [GOC:bhm, PMID:12670962, UniProt:P0A6H5] synonym: "ClpYQ protease complex" EXACT [] is_a: GO:0031597 ! cytosolic proteasome complex is_a: GO:1904949 ! ATPase complex [Term] id: GO:0009377 name: obsolete HslUV protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] comment: This term was made obsolete because it represents a gene product. synonym: "HslUV protease activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0009378 name: four-way junction helicase activity namespace: molecular_function alt_id: GO:1990163 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:al, PMID:22723423, PMID:9442895] synonym: "ATP-dependent four-way junction DNA helicase activity" EXACT [] synonym: "ATP-dependent four-way junction helicase activity" EXACT [] synonym: "ATP-dependent Holliday junction helicase activity" NARROW [] synonym: "Holliday junction helicase activity" NARROW [] is_a: GO:0003678 ! DNA helicase activity created_by: pr creation_date: 2013-08-07T13:36:54Z [Term] id: GO:0009379 name: Holliday junction helicase complex namespace: cellular_component def: "A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895] is_a: GO:0033202 ! DNA helicase complex [Term] id: GO:0009380 name: excinuclease repair complex namespace: cellular_component def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705] synonym: "excinuclease ABC complex" EXACT [] synonym: "UvrABC excinuclease complex" EXACT [] is_a: GO:1905347 ! endodeoxyribonuclease complex is_a: GO:1990391 ! DNA repair complex [Term] id: GO:0009381 name: excinuclease ABC activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0009382 name: imidazoleglycerol-phosphate synthase complex namespace: cellular_component def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009383 name: rRNA (cytosine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] synonym: "rRNA m5C967 methyltransferase activity" NARROW [] xref: Reactome:R-HSA-6790944 "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447" xref: Reactome:R-HSA-6793057 "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841" is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0009384 name: N-acylmannosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] xref: EC:2.7.1.60 xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN xref: Reactome:R-HSA-4085028 "GNE phosphorylates ManNAc to ManNAc-6-P" xref: Reactome:R-HSA-4088322 "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P" xref: RHEA:23832 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009385 name: N-acylmannosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] xref: EC:5.1.3.9 xref: MetaCyc:NANE-RXN xref: RHEA:25257 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0009386 name: translational attenuation namespace: biological_process def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0009388 name: obsolete antisense RNA namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "antisense RNA" EXACT [] is_obsolete: true [Term] id: GO:0009389 name: dimethyl sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_reactionID:r0207] synonym: "dimethyl sulphoxide reductase activity" EXACT [] xref: EC:1.8.99 xref: UM-BBD_reactionID:r0207 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009390 name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] synonym: "dimethyl sulphoxide reductase complex" EXACT [] is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009392 name: N-acetyl-anhydromuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225] xref: MetaCyc:RXN0-5225 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0009394 name: 2'-deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] synonym: "2'-deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0009395 name: phospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid breakdown" EXACT [] synonym: "phospholipid catabolism" EXACT [] synonym: "phospholipid degradation" EXACT [] xref: MIPS_funcat:01.06.04.01 is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0009396 name: folic acid-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] synonym: "folate and derivative biosynthesis" EXACT [] synonym: "folate and derivative biosynthetic process" EXACT [] synonym: "folate-containing compound biosynthesis" EXACT [] synonym: "folate-containing compound biosynthetic process" EXACT [] synonym: "folic acid and derivative biosynthesis" EXACT [] synonym: "folic acid and derivative biosynthetic process" EXACT [] synonym: "folic acid-containing compound anabolism" EXACT [] synonym: "folic acid-containing compound biosynthesis" EXACT [] synonym: "folic acid-containing compound formation" EXACT [] synonym: "folic acid-containing compound synthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] synonym: "vitamin M and derivative biosynthesis" EXACT [] synonym: "vitamin M and derivative biosynthetic process" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009397 name: folic acid-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] synonym: "folate and derivative catabolic process" EXACT [] synonym: "folate and derivative catabolism" EXACT [] synonym: "folate-containing compound catabolic process" EXACT [] synonym: "folate-containing compound catabolism" EXACT [] synonym: "folic acid and derivative catabolic process" EXACT [] synonym: "folic acid and derivative catabolism" EXACT [] synonym: "folic acid-containing compound breakdown" EXACT [] synonym: "folic acid-containing compound catabolism" EXACT [] synonym: "folic acid-containing compound degradation" EXACT [] synonym: "vitamin B9 and derivative catabolic process" EXACT [] synonym: "vitamin B9 and derivative catabolism" EXACT [] synonym: "vitamin M and derivative catabolic process" EXACT [] synonym: "vitamin M and derivative catabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0009398 name: FMN biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai] synonym: "FMN anabolism" EXACT [] synonym: "FMN biosynthesis" EXACT [] synonym: "FMN formation" EXACT [] synonym: "FMN synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009260 ! ribonucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0009399 name: nitrogen fixation namespace: biological_process def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation] xref: MetaCyc:N2FIX-PWY xref: MIPS_funcat:01.02.01.01 xref: Wikipedia:Nitrogen_fixation is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0009400 name: obsolete signal transducer, downstream of receptor, with serine/threonine phosphatase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein serine/threonine phosphatase activity" EXACT [] synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] is_obsolete: true [Term] id: GO:0009401 name: phosphoenolpyruvate-dependent sugar phosphotransferase system namespace: biological_process def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] synonym: "PTS system" NARROW [] xref: MIPS_funcat:20.03.09 is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0009402 name: obsolete toxin resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "toxin resistance" EXACT [] is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_aspergillus subset: goslim_pir synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics synonym: "virulence" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0009406 name: obsolete virulence namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a phenotype rather than a biological process. synonym: "virulence" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0016032 [Term] id: GO:0009407 name: toxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] synonym: "toxin breakdown" EXACT [] synonym: "toxin catabolism" EXACT [] synonym: "toxin degradation" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0098754 ! detoxification [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: goslim_yeast synonym: "response to heat shock" NARROW [] xref: MIPS_funcat:32.01.05 is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] synonym: "freezing tolerance" RELATED [] xref: MIPS_funcat:32.01.06 is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009410 name: response to xenobiotic stimulus namespace: biological_process alt_id: GO:0017104 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009412 name: obsolete response to heavy metal namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "response to heavy metal" EXACT [] is_obsolete: true consider: GO:0010038 [Term] id: GO:0009413 name: response to flooding namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] synonym: "response to water stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.35.09.01 is_a: GO:0001101 ! response to acid chemical is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant xref: MIPS_funcat:34.11.01 xref: MIPS_funcat:34.11.01.01 xref: MIPS_funcat:36.20.35.11 is_a: GO:0009314 ! response to radiation [Term] id: GO:0009417 name: obsolete fimbrin namespace: cellular_component def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] comment: This term was made obsolete because it represents a class of gene products. synonym: "fimbrin" EXACT [] is_obsolete: true replaced_by: GO:0009289 [Term] id: GO:0009418 name: pilus shaft namespace: cellular_component def: "The long, slender, mid section of a pilus." [GOC:jl] synonym: "fimbrial shaft" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009289 ! pilus [Term] id: GO:0009419 name: pilus tip namespace: cellular_component def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl] synonym: "fimbrial tip" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009289 ! pilus [Term] id: GO:0009420 name: bacterial-type flagellum filament namespace: cellular_component def: "The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar filament" EXACT [] synonym: "flagellin-based flagellum filament" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009288 ! bacterial-type flagellum [Term] id: GO:0009421 name: bacterial-type flagellum filament cap namespace: cellular_component def: "The proteinaceous structure at the distal tip of the bacterial-type flagellar filament." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar filament cap" EXACT [] synonym: "flagellin-based flagellum filament cap" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009420 ! bacterial-type flagellum filament [Term] id: GO:0009422 name: bacterial-type flagellum hook-filament junction namespace: cellular_component def: "The region of the bacterial-type flagellum where the hook and filament meet." [GOC:cilia, GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar hook-filament junction" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009288 ! bacterial-type flagellum [Term] id: GO:0009423 name: chorismate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] synonym: "chorismate anabolism" EXACT [] synonym: "chorismate biosynthesis" EXACT [] synonym: "chorismate formation" EXACT [] synonym: "chorismate synthesis" EXACT [] xref: MetaCyc:ARO-PWY is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009424 name: bacterial-type flagellum hook namespace: cellular_component def: "The portion of the bacterial-type flagellum that connects the filament to the basal body." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar hook" EXACT [] synonym: "flagellin-based flagellum hook" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009288 ! bacterial-type flagellum [Term] id: GO:0009425 name: bacterial-type flagellum basal body namespace: cellular_component def: "One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:24697492] synonym: "flagellar basal body" BROAD [] synonym: "flagellin-based flagellum basal body" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009288 ! bacterial-type flagellum [Term] id: GO:0009426 name: bacterial-type flagellum basal body, distal rod namespace: cellular_component def: "The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, distal rod" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009427 name: bacterial-type flagellum basal body, distal rod, L ring namespace: cellular_component def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, distal rod, L ring" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009428 name: bacterial-type flagellum basal body, distal rod, P ring namespace: cellular_component def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, distal rod, P ring" RELATED [] synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009429 name: bacterial-type flagellum basal body, proximal rod namespace: cellular_component def: "The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, proximal rod" EXACT [] synonym: "flagellin-based flagellum basal body, proximal rod" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009431 name: bacterial-type flagellum basal body, MS ring namespace: cellular_component alt_id: GO:0009430 def: "One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, mounting plate" BROAD [] synonym: "flagellar basal body, MS ring" EXACT [] synonym: "flagellin-based flagellum basal body, MS ring" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009432 name: SOS response namespace: biological_process def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023] xref: Wikipedia:SOS_response is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0009433 name: bacterial-type flagellum basal body, C ring namespace: cellular_component def: "Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, C ring" EXACT [] synonym: "flagellin-based flagellum basal body, C ring" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009435 name: NAD biosynthetic process namespace: biological_process alt_id: GO:0006736 def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) biosynthesis" EXACT [] synonym: "NAD (oxidized) biosynthetic process" EXACT [] synonym: "NAD (reduced) biosynthesis" EXACT [] synonym: "NAD (reduced) biosynthetic process" EXACT [] synonym: "NAD anabolism" EXACT [] synonym: "NAD biosynthesis" EXACT [] synonym: "NAD formation" EXACT [] synonym: "NAD synthesis" EXACT [] synonym: "NADH biosynthesis" EXACT [] synonym: "NADH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "oxidized NAD biosynthesis" EXACT [] synonym: "oxidized NAD biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "reduced NAD biosynthesis" EXACT [] synonym: "reduced NAD biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0009436 name: glyoxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] synonym: "glyoxylate breakdown" EXACT [] synonym: "glyoxylate catabolism" EXACT [] synonym: "glyoxylate degradation" EXACT [] xref: MetaCyc:GLYOXDEG-PWY is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046487 ! glyoxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009437 name: carnitine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] synonym: "carnitine metabolism" EXACT [] synonym: "vitamin Bt metabolic process" EXACT [] synonym: "vitamin Bt metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0009438 name: methylglyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] synonym: "methylglyoxal bypass" NARROW [] synonym: "methylglyoxal metabolism" EXACT [] synonym: "methylglyoxal pathway" NARROW [] xref: MetaCyc:METHGLYUT-PWY xref: MIPS_funcat:02.01.01 is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009439 name: cyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] synonym: "cyanate metabolism" EXACT [] xref: MetaCyc:CYANCAT-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009440 name: cyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] synonym: "cyanate breakdown" EXACT [] synonym: "cyanate catabolism" EXACT [] synonym: "cyanate degradation" EXACT [] xref: MIPS_funcat:01.02.01.09.05 is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009441 name: glycolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732] synonym: "glycolate metabolism" EXACT [] xref: MetaCyc:GLYCOLATEMET-PWY is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0009442 name: allantoin assimilation pathway namespace: biological_process def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] synonym: "allantoin catabolism via ureidoglycolate" EXACT [] synonym: "allantoin degradation pathway" RELATED [] xref: MetaCyc:PWY0-41 is_a: GO:0000256 ! allantoin catabolic process [Term] id: GO:0009443 name: pyridoxal 5'-phosphate salvage namespace: biological_process def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "pyridoxal 5' phosphate salvage" EXACT [] xref: MetaCyc:PLPSAL-PWY is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009444 name: pyruvate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY] xref: MetaCyc:PYRUVOX-PWY xref: Wikipedia:Pyruvate_decarboxylation is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0009445 name: putrescine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] synonym: "putrescine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0009446 name: putrescine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732] synonym: "putrescine anabolism" EXACT [] synonym: "putrescine biosynthesis" EXACT [] synonym: "putrescine formation" EXACT [] synonym: "putrescine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009447 name: putrescine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] synonym: "putrescine breakdown" EXACT [] synonym: "putrescine catabolism" EXACT [] synonym: "putrescine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009451 name: RNA modification namespace: biological_process alt_id: GO:0016547 def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. subset: goslim_yeast synonym: "RNA editing" NARROW [GOC:hjd] xref: MIPS_funcat:11.06 xref: Wikipedia:RNA_editing is_a: GO:0016070 ! RNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0009452 name: 7-methylguanosine RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript." [GOC:vw, PMID:9266685] synonym: "m(7)G RNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] synonym: "RNA capping" BROAD [GOC:krc, GOC:mah] is_a: GO:0036260 ! RNA capping [Term] id: GO:0009453 name: energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] synonym: "energytaxis" EXACT [] synonym: "taxis in response to energy source" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0009454 name: aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] synonym: "taxis in response to atmospheric oxygen" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0009455 name: redox taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] synonym: "redoxtaxis" EXACT [] synonym: "taxis in response to redox potential" EXACT [] synonym: "taxis in response to redox stimulus" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis is_a: GO:0051775 ! response to redox state [Term] id: GO:0009457 name: obsolete flavodoxin namespace: molecular_function def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] comment: This term was made obsolete because it represents a class of gene products. synonym: "flavodoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009458 name: obsolete cytochrome namespace: molecular_function def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome" EXACT [] is_obsolete: true consider: GO:0045153 consider: GO:0045154 consider: GO:0045155 consider: GO:0045156 consider: GO:0045157 consider: GO:0045158 [Term] id: GO:0009459 name: obsolete cytochrome a namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome a" EXACT [] is_obsolete: true replaced_by: GO:0045154 [Term] id: GO:0009460 name: obsolete cytochrome b namespace: molecular_function def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009461 name: obsolete cytochrome c namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c" EXACT [] is_obsolete: true replaced_by: GO:0045155 [Term] id: GO:0009462 name: obsolete cytochrome d namespace: molecular_function def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome d" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009463 name: obsolete cytochrome b/b6 namespace: molecular_function def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b/b6" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009464 name: obsolete cytochrome b5 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b5" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009465 name: obsolete soluble cytochrome b562 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "soluble cytochrome b562" EXACT [] is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009466 name: obsolete class I cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009467 name: obsolete monoheme class I cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "monoheme class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009468 name: obsolete diheme class I cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "diheme class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009469 name: obsolete class II cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class II cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009470 name: obsolete class IIa cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IIa cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009471 name: obsolete class III cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class III cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009472 name: obsolete cytochrome c3 (tetraheme) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c3 (tetraheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009473 name: obsolete cytochrome c7 (triheme) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c7 (triheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009474 name: obsolete nonaheme cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "nonaheme cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009475 name: obsolete high-molecular-weight cytochrome c (hexadecaheme) namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "high-molecular-weight cytochrome c (hexadecaheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009476 name: obsolete class IV cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IV cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009477 name: obsolete cytochrome c1 namespace: molecular_function def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c1" EXACT [] is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009478 name: obsolete cytochrome c554 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c554" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009479 name: obsolete cytochrome f namespace: molecular_function def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome f" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009480 name: obsolete class IIb cytochrome c namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IIb cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009481 name: obsolete aa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "aa3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009482 name: obsolete ba3-type cytochrome c oxidase namespace: molecular_function alt_id: GO:0009484 def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "ba3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009483 name: obsolete caa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "caa3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009485 name: obsolete cbb3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "cbb3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009486 name: cytochrome bo3 ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [MetaCyc:RXN0-5268] xref: EC:1.10.3 xref: MetaCyc:RXN0-5268 is_a: GO:0015002 ! heme-copper terminal oxidase activity [Term] id: GO:0009487 name: obsolete glutaredoxin namespace: molecular_function def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "glutaredoxin" EXACT [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 consider: GO:0015038 [Term] id: GO:0009488 name: obsolete amicyanin namespace: molecular_function def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] comment: This term was made obsolete because it does not represent a molecular function. synonym: "amicyanin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009489 name: obsolete rubredoxin namespace: molecular_function def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] comment: This term was made obsolete because it does not represent a molecular function. synonym: "rubredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009490 name: obsolete mononuclear iron electron carrier namespace: molecular_function def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mononuclear iron electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009491 name: obsolete redox-active disulfide bond electron carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "redox-active disulfide bond electron carrier" EXACT [] synonym: "redox-active disulphide bond electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009492 name: obsolete 2Fe-2S electron transfer carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "2Fe-2S electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009493 name: obsolete adrenodoxin-type ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "adrenodoxin-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009494 name: obsolete chloroplast-type ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "chloroplast-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009495 name: obsolete thioredoxin-like 2Fe-2S ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "thioredoxin-like 2Fe-2S ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009496 name: plastoquinol--plastocyanin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane." [EC:1.10.9.1] synonym: "cytochrome b6-f complex activity" RELATED [EC:1.10.9.1] synonym: "cytochrome b6/f complex activity" RELATED [EC:1.10.9.1] synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] synonym: "cytochrome b6f complex activity" RELATED [EC:1.10.9.1] synonym: "plastoquinol-plastocyanin reductase activity" EXACT [EC:1.10.9.1] synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] xref: EC:1.10.9.1 xref: KEGG_REACTION:R03817 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor [Term] id: GO:0009497 name: obsolete 3Fe-4S/4Fe-4S electron transfer carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "3Fe-4S/4Fe-4S electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009498 name: obsolete bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009499 name: obsolete monocluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "monocluster bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009500 name: obsolete dicluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "dicluster bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009501 name: amyloplast namespace: cellular_component def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] xref: MIPS_funcat:70.26.05 xref: Wikipedia:Amyloplast is_a: GO:0009536 ! plastid [Term] id: GO:0009502 name: obsolete photosynthetic electron transport chain namespace: cellular_component def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:0140514031] comment: This term was made obsolete because it represents a process. synonym: "photosynthetic electron transport chain" EXACT [] is_obsolete: true consider: GO:0009767 [Term] id: GO:0009503 name: thylakoid light-harvesting complex namespace: cellular_component def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0030076 ! light-harvesting complex is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex intersection_of: GO:0030076 ! light-harvesting complex intersection_of: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0009504 name: cell plate namespace: cellular_component def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] xref: Wikipedia:Cell_plate is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009505 name: plant-type cell wall namespace: cellular_component def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208] synonym: "cellulose and pectin-containing cell wall" EXACT [] synonym: "plant cell wall" NARROW [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009506 name: plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732] synonym: "plasmodesmata" EXACT [] xref: Wikipedia:Plasmodesma is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0055044 ! symplast [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] subset: goslim_plant xref: MIPS_funcat:70.26.03 xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399] is_a: GO:0000229 ! cytoplasmic chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0042646 ! plastid nucleoid [Term] id: GO:0009509 name: chromoplast namespace: cellular_component def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] xref: MIPS_funcat:70.26.07 xref: Wikipedia:Chromoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009510 name: plasmodesmatal desmotubule namespace: cellular_component alt_id: GO:0009572 def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "desmotubule central rod" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009511 name: plasmodesmatal endoplasmic reticulum namespace: cellular_component def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] synonym: "plasmodesmatal ER" EXACT [] is_a: GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0009510 ! plasmodesmatal desmotubule [Term] id: GO:0009512 name: cytochrome b6f complex namespace: cellular_component def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943088399, PMID:16228398, PMID:16352458] synonym: "cyt b(6)f complex" EXACT [] synonym: "cyt b6-f complex" EXACT [] synonym: "cyt b6/f complex" EXACT [] synonym: "cyt b6f complex" EXACT [] synonym: "cytochrome b(6)f complex" EXACT [] synonym: "cytochrome b6-f complex" EXACT [] synonym: "cytochrome b6/f complex" EXACT [] xref: Wikipedia:Cytochrome_b6f_complex is_a: GO:0070069 ! cytochrome complex relationship: part_of GO:0009579 ! thylakoid [Term] id: GO:0009513 name: etioplast namespace: cellular_component def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943088399] xref: MIPS_funcat:70.26.11 xref: Wikipedia:Etioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009514 name: glyoxysome namespace: cellular_component def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031] xref: Wikipedia:Glyoxysome is_a: GO:0005777 ! peroxisome [Term] id: GO:0009515 name: granal stacked thylakoid namespace: cellular_component def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] synonym: "chloroplast stacked thylakoid" EXACT [] is_a: GO:0009534 ! chloroplast thylakoid intersection_of: GO:0009534 ! chloroplast thylakoid intersection_of: part_of GO:0009542 ! granum relationship: part_of GO:0009542 ! granum [Term] id: GO:0009516 name: leucoplast namespace: cellular_component def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943088399] xref: MIPS_funcat:70.26.13 xref: Wikipedia:Leucoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009517 name: PSII associated light-harvesting complex II namespace: cellular_component def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] synonym: "LHCII" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009518 name: PSI associated light-harvesting complex I namespace: cellular_component def: "Protein-pigment complex associated with photosystem I." [GOC:lr] synonym: "LHCI" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009519 name: middle lamella namespace: cellular_component def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] xref: Wikipedia:Middle_lamella is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0009521 name: photosystem namespace: cellular_component alt_id: GO:0030090 def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: goslim_pir synonym: "reaction center" NARROW [] synonym: "reaction centre" NARROW [] xref: Wikipedia:Photosystem is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0034357 ! photosynthetic membrane [Term] id: GO:0009522 name: photosystem I namespace: cellular_component def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] is_a: GO:0009521 ! photosystem [Term] id: GO:0009523 name: photosystem II namespace: cellular_component def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] xref: Wikipedia:Photosystem_II is_a: GO:0009521 ! photosystem [Term] id: GO:0009524 name: phragmoplast namespace: cellular_component def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] xref: Wikipedia:Phragmoplast is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009525 name: phragmosome namespace: cellular_component def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943088399] xref: Wikipedia:Phragmosome is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0009536 ! plastid [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009528 name: plastid inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] is_a: GO:0019866 ! organelle inner membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009529 name: plastid intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] synonym: "plastid envelope lumen" EXACT [] is_a: GO:0031970 ! organelle envelope lumen relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0009530 name: primary cell wall namespace: cellular_component def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872] is_a: GO:0009505 ! plant-type cell wall [Term] id: GO:0009531 name: secondary cell wall namespace: cellular_component def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399] xref: Wikipedia:Secondary_cell_wall is_a: GO:0009505 ! plant-type cell wall [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:0943088399] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009536 ! plastid [Term] id: GO:0009533 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943088399] is_a: GO:0009534 ! chloroplast thylakoid intersection_of: GO:0009534 ! chloroplast thylakoid intersection_of: part_of GO:0009570 ! chloroplast stroma relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009534 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399] is_a: GO:0031976 ! plastid thylakoid intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009535 name: chloroplast thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: MIPS_funcat:70.26 xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009537 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943088399] is_a: GO:0009536 ! plastid [Term] id: GO:0009538 name: photosystem I reaction center namespace: cellular_component def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] synonym: "photosystem I reaction centre" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009539 name: photosystem II reaction center namespace: cellular_component def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] synonym: "photosystem II reaction centre" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009540 name: zeaxanthin epoxidase [overall] activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O; and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] comment: This is a process composed of two reactions represented by the terms 'GO:0052662 : zeaxanthin epoxidase activity' and 'GO:0052663 : antheraxanthin epoxidase activity'. synonym: "zea-epoxidase activity" RELATED [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.90] xref: EC:1.14.13.90 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0009541 name: etioplast prolamellar body namespace: cellular_component def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009542 name: granum namespace: cellular_component def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:0140514031] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009543 name: chloroplast thylakoid lumen namespace: cellular_component def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399] is_a: GO:0031978 ! plastid thylakoid lumen relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009544 name: chloroplast ATP synthase complex namespace: cellular_component def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:0198547684] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex [Term] id: GO:0009545 name: elaioplast namespace: cellular_component def: "A leucoplast in which oil is stored." [ISBN:0140514031] xref: MIPS_funcat:70.26.09 xref: Wikipedia:Elaioplast is_a: GO:0009516 ! leucoplast [Term] id: GO:0009546 name: plasmodesmatal cytoplasmic sleeve namespace: cellular_component def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0009548 name: plasmodesmatal plasma membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009549 name: cellulose microfibril namespace: cellular_component def: "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009505 ! plant-type cell wall [Term] id: GO:0009550 name: primary plasmodesma namespace: cellular_component def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] synonym: "simple plasmodesma" EXACT [] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009551 name: secondary plasmodesma namespace: cellular_component def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009553 name: embryo sac development namespace: biological_process alt_id: GO:0048230 def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] synonym: "female gametophyte development" EXACT [] xref: MIPS_funcat:41.03.01.02 xref: MIPS_funcat:43.02.17.02 is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009554 name: megasporogenesis namespace: biological_process def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] synonym: "megaspore development" EXACT [] synonym: "megaspore mother cell meiosis" EXACT [] synonym: "meiosis of the megasporocyte" EXACT [] synonym: "meiotic division of the megasporocyte" EXACT [] is_a: GO:0048236 ! plant-type sporogenesis relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009555 name: pollen development namespace: biological_process alt_id: GO:0009564 alt_id: GO:0048231 def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] synonym: "formation of generative and vegetative cells" EXACT [] synonym: "male gametophyte development" EXACT [] synonym: "male gametophyte formation" EXACT [] synonym: "microgametophyte development" EXACT [] synonym: "pollen grain formation" EXACT [] xref: MIPS_funcat:41.03.01.01 xref: MIPS_funcat:43.02.17.01 is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009556 name: microsporogenesis namespace: biological_process def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] synonym: "microspore development" EXACT systematic_synonym [] is_a: GO:0048236 ! plant-type sporogenesis relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0009557 name: antipodal cell differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009558 name: embryo sac cellularization namespace: biological_process alt_id: GO:0009797 def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] synonym: "cellularization of the embryo sac" EXACT [] synonym: "female gametophyte cellularization" EXACT [] synonym: "megagametophyte cellularization" EXACT [] is_a: GO:0007349 ! cellularization relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009559 name: embryo sac central cell differentiation namespace: biological_process def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant] synonym: "embryo sac endosperm mother cell differentiation" EXACT [] synonym: "female gametophyte central cell differentiation" EXACT [] xref: MIPS_funcat:43.02.17.02.03 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009560 name: embryo sac egg cell differentiation namespace: biological_process alt_id: GO:0048233 def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu] synonym: "female gamete generation" BROAD [] synonym: "female gametophyte egg cell differentiation" EXACT [] xref: MIPS_funcat:43.02.17.02.01 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007292 ! female gamete generation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009561 name: megagametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] synonym: "megagametophyte nucleus division" EXACT [] xref: Wikipedia:Megagametogenesis is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009562 name: embryo sac nuclear migration namespace: biological_process def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac nucleus migration" EXACT [] synonym: "female gametophyte nuclear migration" EXACT [] synonym: "female gametophyte nucleus migration" EXACT [] synonym: "megagametophyte nuclear migration" EXACT [] synonym: "megagametophyte nucleus migration" EXACT [] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009563 name: synergid differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid] synonym: "synergid cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009567 name: double fertilization forming a zygote and endosperm namespace: biological_process def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "double fertilization" EXACT [] is_a: GO:0009566 ! fertilization [Term] id: GO:0009568 name: amyloplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "amyloplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain intersection_of: GO:0043036 ! starch grain intersection_of: part_of GO:0009501 ! amyloplast relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0009569 name: chloroplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732] synonym: "chloroplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain intersection_of: GO:0043036 ! starch grain intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009571 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009537 ! proplastid [Term] id: GO:0009573 name: chloroplast ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu] synonym: "chloroplast RubisCO complex" EXACT [] is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009574 name: preprophase band namespace: cellular_component def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732] xref: Wikipedia:Preprophase_band is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0009575 name: chromoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0009576 name: leucoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009516 ! leucoplast [Term] id: GO:0009577 name: elaioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009545 ! elaioplast [Term] id: GO:0009578 name: etioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009580 name: obsolete thylakoid (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific children exist. synonym: "thylakoid (sensu Bacteria)" EXACT [] is_obsolete: true consider: GO:0030075 consider: GO:0042716 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] xref: MIPS_funcat:34.11.01 xref: MIPS_funcat:36.20.35.11 is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009585 name: red, far-red light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction relationship: part_of GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0009587 name: obsolete phototrophin mediated phototransduction namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] synonym: "phototrophin mediated phototransduction" EXACT [] is_obsolete: true replaced_by: GO:0007602 [Term] id: GO:0009588 name: UV-A, blue light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah] synonym: "blue-sensitive opsin" RELATED [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity namespace: biological_process def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb] synonym: "perception of gravity" RELATED [] xref: MIPS_funcat:34.11.07 xref: MIPS_funcat:36.20.35.13 is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009591 name: obsolete perception of mechanical stimulus namespace: biological_process alt_id: GO:0007609 def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. synonym: "perception of mechanical stimulus" EXACT [] is_obsolete: true consider: GO:0050954 [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "chemoreception" RELATED [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] xref: MIPS_funcat:34.11.03 is_a: GO:0051606 ! detection of stimulus relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0009594 name: detection of nutrient namespace: biological_process def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "detection of nutrients" EXACT [] synonym: "nutrient sensing" RELATED [] synonym: "perception of nutrients" RELATED [] xref: MIPS_funcat:34.11.03.01 is_a: GO:0007584 ! response to nutrient is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009595 name: detection of biotic stimulus namespace: biological_process alt_id: GO:0009596 def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] synonym: "perception of biotic stimulus" RELATED [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009597 name: detection of virus namespace: biological_process def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] comment: GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus. synonym: "perception of virus" RELATED [] is_a: GO:0009615 ! response to virus [Term] id: GO:0009600 name: detection of nematode namespace: biological_process def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] synonym: "perception of nematode" RELATED [] is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009601 name: detection of insect namespace: biological_process def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] synonym: "perception of insect" RELATED [] is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009602 name: detection of symbiont namespace: biological_process alt_id: GO:0051855 def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] comment: Merged terms, see https://github.com/geneontology/go-ontology/issues/17977 synonym: "perception of symbiont" RELATED [] synonym: "recognition of symbiont" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0051702 ! interaction with symbiont is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009603 name: detection of symbiotic fungus namespace: biological_process def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] synonym: "detection of symbiotic fungi" EXACT [] synonym: "perception of symbiotic fungi" RELATED [] synonym: "perception of symbiotic fungus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009610 ! response to symbiotic fungus is_a: GO:0016046 ! detection of fungus [Term] id: GO:0009604 name: detection of symbiotic bacterium namespace: biological_process def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] synonym: "detection of symbiotic bacteria" EXACT [] synonym: "perception of symbiotic bacteria" RELATED [] synonym: "perception of symbiotic bacterium" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009609 ! response to symbiotic bacterium is_a: GO:0016045 ! detection of bacterium [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] xref: MIPS_funcat:36.20.35 is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009606 name: tropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088] subset: goslim_plant xref: Wikipedia:Tropism is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009608 name: response to symbiont namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] synonym: "response of host to symbiont" RELATED [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009609 name: response to symbiotic bacterium namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732] synonym: "response to symbiotic bacteria" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009617 ! response to bacterium [Term] id: GO:0009610 name: response to symbiotic fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732] synonym: "response to symbiotic fungi" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009620 ! response to fungus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] xref: MIPS_funcat:34.11.05 xref: MIPS_funcat:36.20.35.15 is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009614 name: obsolete disease resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "disease resistance" EXACT [] is_obsolete: true replaced_by: GO:0051707 [Term] id: GO:0009615 name: response to virus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] synonym: "response to viruses" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009616 name: virus induced gene silencing namespace: biological_process def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl] comment: Virus-induced gene silencing (VIGS) is a RNA-mediated post-transcriptional gene silencing mechanism that protects plants against foreign gene invasion. synonym: "VIGS" EXACT [] synonym: "virus-induced gene silencing" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051607 ! defense response to virus is_a: GO:0052018 ! modulation by symbiont of RNA levels in host is_a: GO:0098586 ! cellular response to virus [Term] id: GO:0009617 name: response to bacterium namespace: biological_process alt_id: GO:0009618 alt_id: GO:0009680 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] synonym: "response to bacteria" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009619 name: obsolete resistance to pathogenic bacteria namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic bacteria" EXACT [] is_obsolete: true replaced_by: GO:0009617 [Term] id: GO:0009620 name: response to fungus namespace: biological_process alt_id: GO:0009621 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009622 name: obsolete resistance to pathogenic fungi namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic fungi" EXACT [] is_obsolete: true replaced_by: GO:0009620 [Term] id: GO:0009624 name: response to nematode namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] synonym: "response to nematodes" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009625 name: response to insect namespace: biological_process alt_id: GO:0043019 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] synonym: "response to insects" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. synonym: "HR" EXACT [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] xref: MIPS_funcat:36.20.16.07 is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! host programmed cell death induced by symbiont is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0045087 ! innate immune response [Term] id: GO:0009627 name: systemic acquired resistance namespace: biological_process def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:0521436125] synonym: "salicylic acid-dependent systemic resistance" EXACT [] xref: MIPS_funcat:36.20.16.05 xref: Wikipedia:Systemic_acquired_resistance is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Changed definition as requested in https://github.com/geneontology/go-ontology/issues/16572. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] synonym: "response to gravitational stimulus" EXACT [] xref: MIPS_funcat:34.11.07 xref: MIPS_funcat:36.20.35.13 is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009630 name: gravitropism namespace: biological_process def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] synonym: "geotropism" EXACT [] xref: MIPS_funcat:36.20.35.13.01 xref: Wikipedia:Gravitropism is_a: GO:0009606 ! tropism is_a: GO:0009629 ! response to gravity [Term] id: GO:0009631 name: cold acclimation namespace: biological_process def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] is_a: GO:0009409 ! response to cold [Term] id: GO:0009632 name: obsolete freezing tolerance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. synonym: "freezing tolerance" EXACT [] is_obsolete: true consider: GO:0009409 [Term] id: GO:0009633 name: obsolete drought tolerance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. synonym: "drought tolerance" EXACT [] is_obsolete: true consider: GO:0009414 consider: GO:0009819 [Term] id: GO:0009634 name: obsolete heavy metal sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "heavy metal sensitivity/resistance" EXACT [] is_obsolete: true consider: GO:0010038 [Term] id: GO:0009635 name: response to herbicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators] synonym: "herbicide susceptibility/resistance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009637 name: response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] synonym: "response to blue light stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009638 name: phototropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491] xref: MIPS_funcat:36.20.35.11.01 xref: Wikipedia:Phototropism is_a: GO:0009606 ! tropism is_a: GO:0009637 ! response to blue light [Term] id: GO:0009639 name: response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009640 name: photomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] synonym: "plant development in response to light" EXACT systematic_synonym [] xref: Wikipedia:Photomorphogenesis is_a: GO:0009639 ! response to red or far red light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009641 name: shade avoidance namespace: biological_process def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance] xref: Wikipedia:Shade_avoidance is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0009642 name: response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009643 name: photosynthetic acclimation namespace: biological_process def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694] synonym: "light acclimatization" EXACT [PMID:11069694] synonym: "photoacclimation" EXACT [GOC:tb] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009644 name: response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009645 name: response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009646 name: response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] synonym: "response to darkness" RELATED [] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009647 name: skotomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] synonym: "etiolation" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009648 name: photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to day length" EXACT [] synonym: "response to night length" EXACT [] synonym: "response to photoperiod" EXACT [] xref: Wikipedia:Photoperiodism is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009649 name: entrainment of circadian clock namespace: biological_process def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] synonym: "regulation of circadian rhythm phase" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0009650 name: UV protection namespace: biological_process def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] synonym: "ultraviolet protection" EXACT [] synonym: "ultraviolet resistance" RELATED [] synonym: "ultraviolet tolerance" RELATED [] synonym: "UV resistance" RELATED [] synonym: "UV tolerance" RELATED [] is_a: GO:0009411 ! response to UV [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0009652 name: thigmotropism namespace: biological_process def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165] xref: Wikipedia:Thigmotropism is_a: GO:0009606 ! tropism is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009654 name: photosystem II oxygen evolving complex namespace: cellular_component def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [GOC:cjm, InterPro:IPR002683] synonym: "OEC (PSII) complex" EXACT [GOC:cjm] synonym: "oxygen evolving complex" EXACT [GOC:cjm] xref: Wikipedia:Oxygen_evolving_complex is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0009523 ! photosystem II relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0009655 name: PSII associated light-harvesting complex II, core complex namespace: cellular_component def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009656 name: PSII associated light-harvesting complex II, peripheral complex namespace: cellular_component def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26 is_a: GO:0006996 ! organelle organization [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.03 is_a: GO:0009657 ! plastid organization [Term] id: GO:0009659 name: leucoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid] synonym: "leucoplast organisation" EXACT [] synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.13 is_a: GO:0009657 ! plastid organization [Term] id: GO:0009660 name: amyloplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid] synonym: "amyloplast organisation" EXACT [] synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.05 is_a: GO:0009657 ! plastid organization [Term] id: GO:0009661 name: chromoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid] synonym: "chromoplast organisation" EXACT [] synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.07 is_a: GO:0009657 ! plastid organization [Term] id: GO:0009662 name: etioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid] synonym: "etioplast organisation" EXACT [] synonym: "etioplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.11 is_a: GO:0009657 ! plastid organization [Term] id: GO:0009663 name: plasmodesma organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah] synonym: "plasmodesma organisation" EXACT [] synonym: "plasmodesma organization and biogenesis" RELATED [] synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0009664 name: plant-type cell wall organization namespace: biological_process def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] synonym: "cell wall organization and biogenesis" NARROW [] synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "plant-type cell wall organisation" EXACT [] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071555 ! cell wall organization is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009667 name: plastid inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid inner membrane organisation" EXACT [] synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0009669 name: sucrose:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] synonym: "sucrose permease activity" RELATED [] synonym: "sucrose:monovalent cation symporter activity" EXACT [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0008515 ! sucrose transmembrane transporter activity [Term] id: GO:0009670 name: triose-phosphate:phosphate antiporter activity namespace: molecular_function alt_id: GO:0015122 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] synonym: "TPT" RELATED [] synonym: "triose phosphate antiporter" EXACT [] synonym: "triose phosphate translocator" EXACT [] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity [Term] id: GO:0009671 name: nitrate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981] synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] synonym: "nitrate(chlorate):proton symporter activity" EXACT [] synonym: "nitrate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity [Term] id: GO:0009672 name: auxin:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] synonym: "auxin:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0009673 name: low-affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] synonym: "low affinity phosphate transmembrane transporter activity" EXACT [] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity [Term] id: GO:0009674 name: potassium:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0009675 name: high-affinity sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity sulfate:hydrogen symporter activity" EXACT [] synonym: "high affinity sulfate:proton symporter activity" EXACT [] synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:proton symporter activity [Term] id: GO:0009676 name: low-affinity sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135] synonym: "low affinity sulfate:hydrogen symporter activity" EXACT [] synonym: "low affinity sulfate:proton symporter activity" EXACT [] synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:proton symporter activity [Term] id: GO:0009677 name: double fertilization forming two zygotes namespace: biological_process def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb] is_a: GO:0009566 ! fertilization [Term] id: GO:0009678 name: pyrophosphate hydrolysis-driven proton transmembrane transporter activity namespace: molecular_function def: "Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force." [GOC:mtg_transport, ISBN:0815340729, Wikipedia:Proton-pumping_pyrophosphatase] synonym: "diphosphate hydrolysis-driven proton transmembrane transporter activity" EXACT [] synonym: "H(+)-exporting diphosphatase" RELATED [EC:7.1.3.1] synonym: "hydrogen-translocating pyrophosphatase activity" EXACT [EC:7.1.3.1] synonym: "PP(i) hydrolysis-driven proton transmembrane transporter activity" EXACT [] synonym: "proton-pumping diphosphatase" RELATED [EC:7.1.3.1] synonym: "proton-pumping pyrophosphatase" RELATED [EC:7.1.3.1] synonym: "proton-translocating pyrophosphatase activity" EXACT [] xref: EC:7.1.3.1 xref: MetaCyc:TRANS-RXN-370 xref: RHEA:13973 xref: TC:3.A.10 is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015399 ! primary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity relationship: has_part GO:0016462 ! pyrophosphatase activity [Term] id: GO:0009679 name: hexose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] synonym: "hexose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0009682 name: induced systemic resistance namespace: biological_process def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] xref: MIPS_funcat:36.20.16.03 is_a: GO:0042742 ! defense response to bacterium is_a: GO:0045087 ! innate immune response [Term] id: GO:0009683 name: indoleacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] synonym: "IAA metabolic process" EXACT [] synonym: "indole acetic acid metabolic process" EXACT [] synonym: "indole acetic acid metabolism" EXACT [] synonym: "indoleacetic acid metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0009684 name: indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] synonym: "IAA biosynthetic process" EXACT [] synonym: "indole acetic acid biosynthesis" EXACT [] synonym: "indole acetic acid biosynthetic process" EXACT [] synonym: "indole-3-acetate biosynthesis" EXACT [] synonym: "indole-3-acetate biosynthetic process" EXACT [] synonym: "indole-acetic acid biosynthesis" EXACT [] synonym: "indole-acetic acid biosynthetic process" RELATED [] synonym: "indoleacetic acid anabolism" EXACT [] synonym: "indoleacetic acid biosynthesis" EXACT [] synonym: "indoleacetic acid formation" EXACT [] synonym: "indoleacetic acid synthesis" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009685 name: gibberellin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] synonym: "gibberellic acid metabolic process" NARROW [] synonym: "gibberellic acid metabolism" NARROW [] synonym: "gibberellin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009686 name: gibberellin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] synonym: "gibberellic acid anabolism" NARROW [] synonym: "gibberellic acid biosynthesis" NARROW [] synonym: "gibberellic acid biosynthetic process" NARROW [] synonym: "gibberellic acid formation" NARROW [] synonym: "gibberellic acid synthesis" NARROW [] synonym: "gibberellin biosynthesis" EXACT [] xref: MetaCyc:PWY-5035 xref: MetaCyc:PWY-5036 xref: MetaCyc:PWY-5052 xref: MetaCyc:PWY-5070 is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009687 name: abscisic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] synonym: "abscisic acid metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043288 ! apocarotenoid metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process [Term] id: GO:0009688 name: abscisic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] synonym: "abscisic acid anabolism" EXACT [] synonym: "abscisic acid biosynthesis" EXACT [] synonym: "abscisic acid formation" EXACT [] synonym: "abscisic acid synthesis" EXACT [] xref: MetaCyc:PWY-695 is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0009689 name: induction of phytoalexin biosynthetic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] synonym: "induction of phytoalexin anabolism" EXACT [] synonym: "induction of phytoalexin biosynthesis" EXACT [] synonym: "induction of phytoalexin formation" EXACT [] synonym: "induction of phytoalexin synthesis" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: goslim_chembl synonym: "cytokinin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009691 name: cytokinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] synonym: "cytokinin anabolism" EXACT [] synonym: "cytokinin biosynthesis" EXACT [] synonym: "cytokinin formation" EXACT [] synonym: "cytokinin synthesis" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009692 name: ethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] synonym: "ethene metabolic process" EXACT [] synonym: "ethene metabolism" EXACT [] synonym: "ethylene metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0009693 name: ethylene biosynthetic process namespace: biological_process alt_id: GO:0042456 def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] synonym: "ethene biosynthesis" EXACT [] synonym: "ethene biosynthesis from L-methionine" EXACT [] synonym: "ethene biosynthetic process" EXACT [] synonym: "ethene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene anabolism" EXACT [] synonym: "ethylene biosynthesis" EXACT [] synonym: "ethylene biosynthesis from L-methionine" EXACT [] synonym: "ethylene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene formation" EXACT [] synonym: "ethylene synthesis" EXACT [] xref: MetaCyc:ETHYL-PWY is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009694 name: jasmonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] synonym: "jasmonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009695 name: jasmonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] synonym: "jasmonic acid anabolism" EXACT [] synonym: "jasmonic acid biosynthesis" EXACT [] synonym: "jasmonic acid formation" EXACT [] synonym: "jasmonic acid synthesis" EXACT [] xref: MetaCyc:PWY-735 is_a: GO:0009694 ! jasmonic acid metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009696 name: salicylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] synonym: "salicylic acid metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0009697 name: salicylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] synonym: "salicylate biosynthetic process" EXACT [] synonym: "salicylic acid anabolism" EXACT [] synonym: "salicylic acid biosynthesis" EXACT [] synonym: "salicylic acid formation" EXACT [] synonym: "salicylic acid synthesis" EXACT [] xref: MetaCyc:PWY-981 is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009698 name: phenylpropanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] synonym: "phenylpropanoid metabolism" EXACT [] xref: MetaCyc:PWY1F-467 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009699 name: phenylpropanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] synonym: "phenylpropanoid anabolism" EXACT [] synonym: "phenylpropanoid biosynthesis" EXACT [] synonym: "phenylpropanoid formation" EXACT [] synonym: "phenylpropanoid synthesis" EXACT [] xref: MIPS_funcat:01.20.35.01 is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009700 name: indole phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] synonym: "indole phytoalexin anabolism" EXACT [] synonym: "indole phytoalexin biosynthesis" EXACT [] synonym: "indole phytoalexin formation" EXACT [] synonym: "indole phytoalexin synthesis" EXACT [] is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009701 name: isoflavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin anabolism" EXACT [] synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] synonym: "isoflavonoid phytoalexin formation" EXACT [] synonym: "isoflavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009717 ! isoflavonoid biosynthetic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009702 name: L-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.46, RHEA:20153] synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] xref: EC:2.7.1.46 xref: KEGG_REACTION:R01754 xref: MetaCyc:L-ARABINOKINASE-RXN xref: RHEA:20153 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009703 name: nitrate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1] comment: Note that this function was formerly EC:1.6.6.1. synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate reductase activity" EXACT [] synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] xref: EC:1.7.1.1 xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN xref: RHEA:17913 is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity [Term] id: GO:0009704 name: de-etiolation namespace: biological_process def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] is_a: GO:0009416 ! response to light stimulus relationship: part_of GO:0009640 ! photomorphogenesis [Term] id: GO:0009705 name: plant-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208] synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] synonym: "tonoplast" EXACT [] synonym: "vacuolar membrane" BROAD [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0009706 name: chloroplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] synonym: "chloroplast inner envelope" EXACT [] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009708 name: benzyl isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732] synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] synonym: "benzyl isoquinoline alkaloid formation" EXACT [] synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process [Term] id: GO:0009709 name: terpenoid indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] synonym: "terpenoid indole alkaloid anabolism" EXACT [] synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] synonym: "terpenoid indole alkaloid formation" EXACT [] synonym: "terpenoid indole alkaloid synthesis" EXACT [] is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process [Term] id: GO:0009710 name: tropane alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732] synonym: "tropane alkaloid anabolism" EXACT [] synonym: "tropane alkaloid biosynthesis" EXACT [] synonym: "tropane alkaloid formation" EXACT [] synonym: "tropane alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009711 name: purine alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] synonym: "purine alkaloid anabolism" EXACT [] synonym: "purine alkaloid biosynthesis" EXACT [] synonym: "purine alkaloid formation" EXACT [] synonym: "purine alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0046446 ! purine alkaloid metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0009712 name: catechol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] synonym: "catechol metabolic process" RELATED [] synonym: "catechol metabolism" RELATED [] is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0009713 name: catechol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol anabolism" RELATED [] synonym: "catechol biosynthesis" RELATED [] synonym: "catechol biosynthetic process" RELATED [] synonym: "catechol formation" RELATED [] synonym: "catechol synthesis" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0009714 name: chalcone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732] synonym: "chalcone metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009715 name: chalcone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] synonym: "chalcone anabolism" EXACT [] synonym: "chalcone biosynthesis" EXACT [] synonym: "chalcone formation" EXACT [] synonym: "chalcone synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0009716 name: flavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] synonym: "flavonoid phytoalexin anabolism" EXACT [] synonym: "flavonoid phytoalexin biosynthesis" EXACT [] synonym: "flavonoid phytoalexin formation" EXACT [] synonym: "flavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009717 name: isoflavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] synonym: "isoflavonoid anabolism" EXACT [] synonym: "isoflavonoid biosynthesis" EXACT [] synonym: "isoflavonoid formation" EXACT [] synonym: "isoflavonoid synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046287 ! isoflavonoid metabolic process [Term] id: GO:0009718 name: anthocyanin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] synonym: "anthocyanin anabolism" EXACT [] synonym: "anthocyanin biosynthesis" EXACT [] synonym: "anthocyanin biosynthetic process" EXACT [] synonym: "anthocyanin formation" EXACT [] synonym: "anthocyanin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009720 name: detection of hormone stimulus namespace: biological_process def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of hormone stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009725 ! response to hormone is_a: GO:0009726 ! detection of endogenous stimulus [Term] id: GO:0009721 name: detection of auxin stimulus namespace: biological_process def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of auxin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009733 ! response to auxin [Term] id: GO:0009722 name: detection of cytokinin stimulus namespace: biological_process def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of cytokinin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009735 ! response to cytokinin [Term] id: GO:0009723 name: response to ethylene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] synonym: "response to ethene stimulus" EXACT [] synonym: "response to ethylene stimulus" EXACT [] xref: MIPS_funcat:36.20.18.02 is_a: GO:0009725 ! response to hormone [Term] id: GO:0009724 name: detection of abscisic acid stimulus namespace: biological_process def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of abscisic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009737 ! response to abscisic acid [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009726 name: detection of endogenous stimulus namespace: biological_process def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of endogenous stimulus" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009727 name: detection of ethylene stimulus namespace: biological_process def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "detection of ethene stimulus" EXACT [] synonym: "perception of ethene stimulus" RELATED [] synonym: "perception of ethylene stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009723 ! response to ethylene [Term] id: GO:0009728 name: detection of gibberellic acid stimulus namespace: biological_process def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of gibberellic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009739 ! response to gibberellin [Term] id: GO:0009729 name: detection of brassinosteroid stimulus namespace: biological_process def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of brassinosteroid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009741 ! response to brassinosteroid [Term] id: GO:0009730 name: detection of carbohydrate stimulus namespace: biological_process def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of carbohydrate stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0009731 name: detection of sucrose stimulus namespace: biological_process def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of sucrose stimulus" RELATED [] is_a: GO:0009744 ! response to sucrose is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0009732 name: detection of hexose stimulus namespace: biological_process def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] synonym: "perception of hexose stimulus" RELATED [] is_a: GO:0009746 ! response to hexose is_a: GO:0034287 ! detection of monosaccharide stimulus [Term] id: GO:0009733 name: response to auxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] synonym: "response to auxin stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.18.01 is_a: GO:0009725 ! response to hormone [Term] id: GO:0009734 name: auxin-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826] synonym: "auxin mediated signaling pathway" RELATED [] synonym: "auxin mediated signalling" EXACT [] synonym: "auxin signal transduction" EXACT [PMID:16990790] synonym: "auxin signaling" EXACT [PMID:18647826] synonym: "auxin-regulated transcription" RELATED [PMID:15917797] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071365 ! cellular response to auxin stimulus [Term] id: GO:0009735 name: response to cytokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] synonym: "response to cytokinin stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.18.04 is_a: GO:0009725 ! response to hormone [Term] id: GO:0009736 name: cytokinin-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:sm, PMID:24080474] synonym: "cytokinin mediated signaling pathway" RELATED [] synonym: "cytokinin mediated signalling" EXACT [] synonym: "cytokinin signaling" EXACT [PMID:24080474] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071368 ! cellular response to cytokinin stimulus [Term] id: GO:0009737 name: response to abscisic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] synonym: "response to abscisic acid stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.18.05 is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol [Term] id: GO:0009738 name: abscisic acid-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription." [GOC:signaling, GOC:sm, PMID:24269821] synonym: "ABA signal transduction" EXACT [PMID:20713515] synonym: "ABA signaling" EXACT [PMID:24269821] synonym: "abscisic acid mediated signalling" EXACT [] synonym: "abscisic acid signal transduction" RELATED [PMID:20713515] synonym: "abscisic acid-mediated signaling pathway" RELATED [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071215 ! cellular response to abscisic acid stimulus [Term] id: GO:0009739 name: response to gibberellin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] synonym: "response to gibberellic acid stimulus" NARROW [] synonym: "response to gibberellin stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.18.03 is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009740 name: gibberellic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] synonym: "GA-signaling" EXACT [] synonym: "gibberellic acid mediated signalling" EXACT [] synonym: "gibberellic acid signaling" EXACT [] is_a: GO:0010476 ! gibberellin mediated signaling pathway [Term] id: GO:0009741 name: response to brassinosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] synonym: "response to brassinosteroid stimulus" EXACT [GOC:dos] xref: MIPS_funcat:36.20.18.06 is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009742 name: brassinosteroid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] synonym: "brassinosteroid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway relationship: part_of GO:0071367 ! cellular response to brassinosteroid stimulus [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009744 name: response to sucrose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] synonym: "response to sucrose stimulus" EXACT [GOC:dos] is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0009745 name: sucrose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] synonym: "sucrose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway relationship: part_of GO:0071329 ! cellular response to sucrose stimulus [Term] id: GO:0009746 name: response to hexose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] synonym: "response to hexose stimulus" EXACT [GOC:dos] is_a: GO:0034284 ! response to monosaccharide [Term] id: GO:0009747 name: hexokinase-dependent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-dependent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009748 name: hexokinase-independent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-independent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009749 name: response to glucose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] synonym: "response to glucose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0009750 name: response to fructose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] synonym: "response to fructose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0009751 name: response to salicylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] synonym: "response to salicylate" EXACT [GOC:dph] synonym: "response to salicylic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009752 name: detection of salicylic acid stimulus namespace: biological_process def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of salicylic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009751 ! response to salicylic acid [Term] id: GO:0009753 name: response to jasmonic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009754 name: detection of jasmonic acid stimulus namespace: biological_process def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] synonym: "perception of jasmonic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009726 ! detection of endogenous stimulus is_a: GO:0009753 ! response to jasmonic acid [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] xref: MIPS_funcat:30.01.09.08 is_a: GO:0007165 ! signal transduction relationship: part_of GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0009756 name: carbohydrate mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] synonym: "carbohydrate mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0009757 name: hexose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] synonym: "hexose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway relationship: part_of GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0009758 name: carbohydrate utilization namespace: biological_process alt_id: GO:0007587 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg] synonym: "sugar utilization" NARROW [GOC:mcc2] xref: MIPS_funcat:01.05.01 is_a: GO:0008150 ! biological_process relationship: has_part GO:0005975 ! carbohydrate metabolic process relationship: has_part GO:0008643 ! carbohydrate transport relationship: has_part GO:0009730 ! detection of carbohydrate stimulus [Term] id: GO:0009759 name: indole glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] synonym: "indole glucosinolate anabolism" EXACT [] synonym: "indole glucosinolate biosynthesis" EXACT [] synonym: "indole glucosinolate formation" EXACT [] synonym: "indole glucosinolate synthesis" EXACT [] xref: MetaCyc:PWY-601 is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0009760 name: C4 photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] xref: Wikipedia:C4_carbon_fixation is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009761 name: CAM photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] xref: Wikipedia:Crassulacean_acid_metabolism is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009762 name: NADP-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] xref: MetaCyc:PWY-241 is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009763 name: NAD-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009764 name: PEP carboxykinase C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009765 name: photosynthesis, light harvesting namespace: biological_process def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] synonym: "energy dissipation" RELATED [] is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009766 name: primary charge separation namespace: biological_process def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009767 name: photosynthetic electron transport chain namespace: biological_process alt_id: GO:0009774 alt_id: GO:0009775 alt_id: GO:0009776 def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW [] synonym: "photosynthetic electron transport in plastocyanin" NARROW [] synonym: "photosynthetic electron transport in plastoquinone" NARROW [] is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009768 name: photosynthesis, light harvesting in photosystem I namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009769 name: photosynthesis, light harvesting in photosystem II namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009770 name: primary charge separation in photosystem I namespace: biological_process def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009771 name: primary charge separation in photosystem II namespace: biological_process def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009772 name: photosynthetic electron transport in photosystem II namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009773 name: photosynthetic electron transport in photosystem I namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009777 name: photosynthetic phosphorylation namespace: biological_process def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] synonym: "photosynthetic ATP synthesis" NARROW [] is_a: GO:0016310 ! phosphorylation is_a: GO:0046034 ! ATP metabolic process relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009778 name: cyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009779 name: noncyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009780 name: photosynthetic NADP+ reduction namespace: biological_process def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360] is_a: GO:0006740 ! NADPH regeneration relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009781 name: obsolete photosynthetic water oxidation namespace: biological_process def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360] comment: This term was made obsolete because it represents a molecular function. synonym: "photosynthetic water oxidation" EXACT [] is_obsolete: true replaced_by: GO:0010242 [Term] id: GO:0009782 name: photosystem I antenna complex namespace: cellular_component def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009783 name: photosystem II antenna complex namespace: cellular_component def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009784 name: transmembrane receptor histidine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0009785 name: blue light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] synonym: "blue light signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0071483 ! cellular response to blue light [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008356 ! asymmetric cell division relationship: regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0009787 name: regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009738 ! abscisic acid-activated signaling pathway relationship: regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009788 name: negative regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "down regulation of abscisic acid mediated signaling" EXACT [] synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] synonym: "downregulation of abscisic acid mediated signaling" EXACT [] synonym: "inhibition of abscisic acid mediated signaling" NARROW [] synonym: "negative regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1905958 ! negative regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway relationship: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009789 name: positive regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "activation of abscisic acid mediated signaling" NARROW [] synonym: "positive regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] synonym: "stimulation of abscisic acid mediated signaling" NARROW [] synonym: "up regulation of abscisic acid mediated signaling" EXACT [] synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] synonym: "upregulation of abscisic acid mediated signaling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1905959 ! positive regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway relationship: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] xref: MIPS_funcat:41.05.03 is_a: GO:0009790 ! embryo development [Term] id: GO:0009793 name: embryo development ending in seed dormancy namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] xref: MIPS_funcat:41.03.03 xref: MIPS_funcat:47.02.01.05.01 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009790 ! embryo development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009794 name: regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "embryonic mitotic cell cycle modulation" EXACT [] synonym: "embryonic mitotic cell cycle regulation" EXACT [] synonym: "embryonic mitotic cell cycle regulator" RELATED [] synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045448 ! mitotic cell cycle, embryonic relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] xref: MIPS_funcat:41.05.19 is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009799 name: specification of symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] synonym: "determination of symmetry" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009800 name: cinnamic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] synonym: "cinnamic acid anabolism" EXACT [] synonym: "cinnamic acid biosynthesis" EXACT [] synonym: "cinnamic acid formation" EXACT [] synonym: "cinnamic acid synthesis" EXACT [] synonym: "cinnamylic acid biosynthesis" EXACT [] synonym: "cinnamylic acid biosynthetic process" EXACT [] synonym: "phenylacrylic acid biosynthesis" EXACT [] synonym: "phenylacrylic acid biosynthetic process" EXACT [] synonym: "phenylpropenoic acid biosynthesis" EXACT [] synonym: "phenylpropenoic acid biosynthetic process" EXACT [] xref: MIPS_funcat:01.20.35.01.09 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009803 ! cinnamic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009801 name: cinnamic acid ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] synonym: "cinnamic acid ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009802 name: cinnamic acid ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] synonym: "cinnamic acid ester anabolism" EXACT [] synonym: "cinnamic acid ester biosynthesis" EXACT [] synonym: "cinnamic acid ester formation" EXACT [] synonym: "cinnamic acid ester synthesis" EXACT [] synonym: "cinnamylic acid ester biosynthesis" EXACT [] synonym: "cinnamylic acid ester biosynthetic process" EXACT [] synonym: "phenylacrylic acid ester biosynthesis" EXACT [] synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009801 ! cinnamic acid ester metabolic process relationship: part_of GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009803 name: cinnamic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] synonym: "cinnamic acid metabolism" EXACT [] synonym: "cinnamylic acid metabolic process" EXACT [] synonym: "cinnamylic acid metabolism" EXACT [] synonym: "phenylacrylic acid metabolic process" EXACT [] synonym: "phenylacrylic acid metabolism" EXACT [] synonym: "phenylpropenoic acid metabolic process" EXACT [] synonym: "phenylpropenoic acid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0009804 name: coumarin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] synonym: "coumarin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009805 name: coumarin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] synonym: "coumarin anabolism" EXACT [] synonym: "coumarin biosynthesis" EXACT [] synonym: "coumarin formation" EXACT [] synonym: "coumarin synthesis" EXACT [] xref: MetaCyc:PWY-5176 xref: MIPS_funcat:01.20.35.01.07 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0009806 name: lignan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] synonym: "lignan metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009807 name: lignan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] synonym: "lignan anabolism" EXACT [] synonym: "lignan biosynthesis" EXACT [] synonym: "lignan formation" EXACT [] synonym: "lignan synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009806 ! lignan metabolic process [Term] id: GO:0009808 name: lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] synonym: "lignin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009809 name: lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] synonym: "lignin anabolism" EXACT [] synonym: "lignin biosynthesis" EXACT [] synonym: "lignin formation" EXACT [] synonym: "lignin synthesis" EXACT [] xref: MetaCyc:PWY-361 xref: MIPS_funcat:01.20.35.01.03 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009808 ! lignin metabolic process [Term] id: GO:0009810 name: stilbene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:3110116251] synonym: "stilbene metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009811 name: stilbene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] synonym: "stilbene anabolism" EXACT [] synonym: "stilbene biosynthesis" EXACT [] synonym: "stilbene formation" EXACT [] synonym: "stilbene synthesis" EXACT [] xref: MIPS_funcat:01.20.35.01.05 is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009812 name: flavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] synonym: "flavonoid metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0009813 name: flavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] synonym: "flavonoid anabolism" EXACT [] synonym: "flavonoid biosynthesis" EXACT [] synonym: "flavonoid formation" EXACT [] synonym: "flavonoid synthesis" EXACT [] xref: MetaCyc:PWY1F-FLAVSYN xref: MIPS_funcat:01.20.35.01.05 xref: Wikipedia:Flavonoid is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009814 name: defense response, incompatible interaction namespace: biological_process def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response incompatible interaction" EXACT [] synonym: "defence response to pathogen, incompatible interaction" EXACT [] synonym: "resistance response to pathogen" EXACT [] synonym: "response to pathogen (incompatible interaction)" EXACT [] is_a: GO:0045087 ! innate immune response [Term] id: GO:0009815 name: 1-aminocyclopropane-1-carboxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene." [EC:1.14.17.4, RHEA:23640] synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] synonym: "ACC oxidase activity" EXACT [] synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] synonym: "ethene-forming enzyme" BROAD [] synonym: "ethylene-forming enzyme" BROAD [] xref: EC:1.14.17.4 xref: KEGG_REACTION:R07214 xref: MetaCyc:ETHYL-RXN xref: RHEA:23640 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0009816 name: defense response to bacterium, incompatible interaction namespace: biological_process def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to bacterium, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic bacteria" EXACT [] synonym: "resistance response to pathogenic bacterium" EXACT [] synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT [] synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0009817 name: defense response to fungus, incompatible interaction namespace: biological_process def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to fungus, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT [] synonym: "defense response to fungi, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic fungi" EXACT [] synonym: "resistance response to pathogenic fungus" EXACT [] synonym: "response to pathogenic fungi (incompatible interaction)" EXACT [] synonym: "response to pathogenic fungus (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0009818 name: defense response to protozoan, incompatible interaction namespace: biological_process def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT [] synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT [] synonym: "defence response to protozoan, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic protozoa" EXACT [] synonym: "resistance response to pathogenic protozoan" EXACT [] synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT [] synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042832 ! defense response to protozoan [Term] id: GO:0009819 name: drought recovery namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] synonym: "drought tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] xref: MIPS_funcat:01.20.17.09 xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009822 name: alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] synonym: "alkaloid breakdown" EXACT [] synonym: "alkaloid catabolism" EXACT [] synonym: "alkaloid degradation" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009823 name: cytokinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] synonym: "cytokinin breakdown" EXACT [] synonym: "cytokinin catabolism" EXACT [] synonym: "cytokinin degradation" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009824 name: AMP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [EC:2.5.1.27, RHEA:15285] synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R04038] synonym: "adenylate dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "adenylate isopentenyltransferase activity" EXACT [] synonym: "cytokinin synthase activity" RELATED [] synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "isopentenyltransferase activity" BROAD [] xref: EC:2.5.1.27 xref: KEGG_REACTION:R04038 xref: MetaCyc:RXN-4307 xref: RHEA:15285 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0009825 name: multidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] synonym: "cell growth in three dimensions" EXACT [] synonym: "cell growth in two dimensions" NARROW [] is_a: GO:0016049 ! cell growth [Term] id: GO:0009826 name: unidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. synonym: "cell elongation" NARROW [] synonym: "cell growth along one axis" EXACT [] synonym: "cell growth in one dimension" EXACT [] synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] synonym: "polar cell growth" EXACT [] synonym: "polarized cell growth" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0016049 ! cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0009827 name: plant-type cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall modification" EXACT [] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0042545 ! cell wall modification [Term] id: GO:0009828 name: plant-type cell wall loosening namespace: biological_process def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] is_a: GO:0009827 ! plant-type cell wall modification [Term] id: GO:0009829 name: cell wall modification involved in fruit ripening namespace: biological_process def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening." [GOC:lr] synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0042545 ! cell wall modification intersection_of: part_of GO:0009835 ! fruit ripening relationship: part_of GO:0009835 ! fruit ripening [Term] id: GO:0009830 name: cell wall modification involved in abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb] synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0044277 ! cell wall disassembly intersection_of: GO:0042545 ! cell wall modification intersection_of: part_of GO:0009838 ! abscission relationship: part_of GO:0009838 ! abscission [Term] id: GO:0009831 name: plant-type cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cell wall modification during cell expansion" BROAD [] synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED [] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth intersection_of: GO:0009827 ! plant-type cell wall modification intersection_of: part_of GO:0009825 ! multidimensional cell growth [Term] id: GO:0009832 name: plant-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009833 name: plant-type primary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] synonym: "primary cell wall anabolism" BROAD [] synonym: "primary cell wall biogenesis" EXACT [] synonym: "primary cell wall biosynthetic process" BROAD [] synonym: "primary cell wall formation" BROAD [] synonym: "primary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis [Term] id: GO:0009834 name: plant-type secondary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall anabolism" BROAD [] synonym: "secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall biosynthetic process" BROAD [] synonym: "secondary cell wall formation" BROAD [] synonym: "secondary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009835 name: fruit ripening namespace: biological_process def: "An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal." [GOC:lr] subset: goslim_plant synonym: "fruit maturation" RELATED [GOC:PO_curators] synonym: "fruit senescence" RELATED [GOC:PO_curators] xref: MIPS_funcat:41.03.08 xref: Wikipedia:Ripening is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007568 ! aging is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0009836 name: fruit ripening, climacteric namespace: biological_process def: "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! fruit ripening [Term] id: GO:0009837 name: fruit ripening, non-climacteric namespace: biological_process def: "A fruit ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! fruit ripening [Term] id: GO:0009838 name: abscission namespace: biological_process def: "The controlled shedding of a body part." [ISBN:0140514031] subset: goslim_plant xref: Wikipedia:Abscission is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0009839 name: obsolete SCF complex substrate recognition subunit namespace: cellular_component def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "SCF complex substrate recognition subunit" EXACT [] is_obsolete: true replaced_by: GO:0019005 [Term] id: GO:0009840 name: chloroplastic endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex intersection_of: GO:0009368 ! endopeptidase Clp complex intersection_of: part_of GO:0009570 ! chloroplast stroma relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009841 name: mitochondrial endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0009368 ! endopeptidase Clp complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009842 name: cyanelle namespace: cellular_component def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:0521316871, ISBN:1402001894] synonym: "cyanoplast" EXACT [ISBN:1402001894] synonym: "muroplast" EXACT [ISBN:1402001894] is_a: GO:0009536 ! plastid [Term] id: GO:0009843 name: cyanelle thylakoid namespace: cellular_component def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] is_a: GO:0031976 ! plastid thylakoid intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009842 ! cyanelle relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0009844 name: obsolete germination namespace: biological_process alt_id: GO:0009565 def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] comment: This term was made obsolete because it is a grouping term without biological significance. synonym: "germination" EXACT [] is_obsolete: true [Term] id: GO:0009845 name: seed germination namespace: biological_process def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] xref: MIPS_funcat:41.03.05 xref: Wikipedia:Germination#Seed_germination is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0090351 ! seedling development [Term] id: GO:0009846 name: pollen germination namespace: biological_process def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] is_a: GO:0022414 ! reproductive process is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009847 name: spore germination namespace: biological_process def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] xref: MIPS_funcat:43.01.02.07 is_a: GO:0032502 ! developmental process [Term] id: GO:0009848 name: indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] synonym: "IAA biosynthetic process via tryptophan" EXACT [] synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] synonym: "indoleacetic acid formation via tryptophan" EXACT [] synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009849 name: tryptophan-independent indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009850 name: auxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] synonym: "auxin metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009851 name: auxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] synonym: "auxin anabolism" EXACT [] synonym: "auxin biosynthesis" EXACT [] synonym: "auxin formation" EXACT [] synonym: "auxin synthesis" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009852 name: auxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] synonym: "auxin breakdown" EXACT [] synonym: "auxin catabolism" EXACT [] synonym: "auxin degradation" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009853 name: photorespiration namespace: biological_process def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732] xref: MetaCyc:PWY-181 xref: Wikipedia:Photorespiration is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009854 name: oxidative photosynthetic carbon pathway namespace: biological_process def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:0943088399] is_a: GO:0043094 ! cellular metabolic compound salvage relationship: part_of GO:0009853 ! photorespiration [Term] id: GO:0009855 name: determination of bilateral symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] synonym: "determination of bilateral asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry [Term] id: GO:0009856 name: pollination namespace: biological_process def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion." [GOC:tb, PMID:10973091] subset: goslim_plant xref: Wikipedia:Pollination is_a: GO:0022414 ! reproductive process relationship: part_of GO:0044706 ! multi-multicellular organism process [Term] id: GO:0009858 name: obsolete compatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "compatible pollen-pistil interaction" EXACT [] is_obsolete: true [Term] id: GO:0009859 name: pollen hydration namespace: biological_process def: "The process in which water is taken up by pollen." [GOC:lr] is_a: GO:0006833 ! water transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009860 name: pollen tube growth namespace: biological_process def: "Growth of pollen via tip extension of the intine wall." [ISBN:0943088399] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009932 ! cell tip growth is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009861 name: jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] is_a: GO:0009611 ! response to wounding is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009862 name: systemic acquired resistance, salicylic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0009863 ! salicylic acid mediated signaling pathway intersection_of: GO:0009863 ! salicylic acid mediated signaling pathway intersection_of: part_of GO:0009627 ! systemic acquired resistance relationship: part_of GO:0009627 ! systemic acquired resistance [Term] id: GO:0009863 name: salicylic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] synonym: "salicylic acid mediated signal transduction" EXACT [GOC:signaling] synonym: "salicylic acid mediated signalling pathway" EXACT [] synonym: "salicylic acid-mediated signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071446 ! cellular response to salicylic acid stimulus [Term] id: GO:0009864 name: induced systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009867 ! jasmonic acid mediated signaling pathway intersection_of: GO:0009867 ! jasmonic acid mediated signaling pathway intersection_of: part_of GO:0009682 ! induced systemic resistance relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009865 name: pollen tube adhesion namespace: biological_process def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0098609 ! cell-cell adhesion is_a: GO:0098740 ! multi organism cell adhesion relationship: part_of GO:0009875 ! pollen-pistil interaction relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009866 name: induced systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009873 ! ethylene-activated signaling pathway intersection_of: GO:0009873 ! ethylene-activated signaling pathway intersection_of: part_of GO:0009682 ! induced systemic resistance relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009867 name: jasmonic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850] synonym: "JA signaling" EXACT [PMID:20159850] synonym: "jasmonate signaling" RELATED [PMID:16478936] synonym: "jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071395 ! cellular response to jasmonic acid stimulus [Term] id: GO:0009868 name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009867 ! jasmonic acid mediated signaling pathway intersection_of: GO:0009867 ! jasmonic acid mediated signaling pathway intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance relationship: part_of GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009869 name: obsolete incompatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] comment: This term was made obsolete because it represents a phenotype. synonym: "incompatible pollen-pistil interaction" EXACT [] is_obsolete: true [Term] id: GO:0009870 name: defense response signaling pathway, resistance gene-dependent namespace: biological_process def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339] synonym: "defence response signaling pathway, resistance gene-dependent" EXACT [] synonym: "defence response signalling pathway, resistance gene-dependent" EXACT [] synonym: "defense response signalling pathway, resistance gene-dependent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0009871 name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0009873 ! ethylene-activated signaling pathway intersection_of: GO:0009873 ! ethylene-activated signaling pathway intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009872 name: obsolete gametophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "gametophytic self-incompatibility" EXACT [] is_obsolete: true [Term] id: GO:0009873 name: ethylene-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription." [GOC:jy, PMID:24012247] synonym: "ethene mediated signaling pathway" RELATED [] synonym: "ethene mediated signalling pathway" EXACT [] synonym: "ethylene mediated signaling pathway" RELATED [] synonym: "ethylene mediated signalling pathway" RELATED [] synonym: "ethylene signal transduction" RELATED [PMID:24012247] synonym: "ethylene signaling pathway" RELATED [PMID:24287137] is_a: GO:0000160 ! phosphorelay signal transduction system is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071369 ! cellular response to ethylene stimulus [Term] id: GO:0009874 name: obsolete sporophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "sporophytic self-incompatibility" EXACT [] is_obsolete: true [Term] id: GO:0009875 name: pollen-pistil interaction namespace: biological_process def: "The interaction between a pollen grain and pistil." [PMID:27899537] synonym: "pollen-gynoecium interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009876 name: pollen adhesion namespace: biological_process def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] is_a: GO:0022414 ! reproductive process is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009877 name: nodulation namespace: biological_process def: "The formation of nitrogen-fixing root nodules on plant roots." [UniProtKB-KW:KW-0536] synonym: "nodule development" EXACT [GOC:jl] synonym: "nodule formation" EXACT [GOC:jl] is_a: GO:0044403 ! symbiotic process [Term] id: GO:0009878 name: nodule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nodule are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044111 ! development involved in symbiotic interaction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: part_of GO:0009877 ! nodulation relationship: part_of GO:0009877 ! nodulation [Term] id: GO:0009879 name: determination of radial symmetry namespace: biological_process def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] synonym: "determination of radial asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0009881 name: photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] xref: Reactome:R-HSA-2465917 "Photons induce isomerisation of 11c-retinyl to at-retinyl" xref: Reactome:R-HSA-74101 "Photons induce isomerization of 11c-retinyl to at-retinyl" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0009882 name: blue light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009785 ! blue light signaling pathway [Term] id: GO:0009883 name: red or far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] synonym: "red/far-red light photoreceptor activity" EXACT [] is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009585 ! red, far-red light phototransduction [Term] id: GO:0009884 name: cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:lr, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0009736 ! cytokinin-activated signaling pathway [Term] id: GO:0009885 name: transmembrane histidine kinase cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] is_a: GO:0009784 ! transmembrane receptor histidine kinase activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0009886 name: post-embryonic animal morphogenesis namespace: biological_process def: "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators] synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009056 ! catabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009056 ! catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009056 ! catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009897 name: external side of plasma membrane namespace: cellular_component def: "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] synonym: "external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "juxtamembrane" BROAD [] synonym: "outer surface of cytoplasmic membrane" EXACT [] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009898 name: cytoplasmic side of plasma membrane namespace: cellular_component def: "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] synonym: "internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "internal side of plasma membrane" EXACT [] synonym: "juxtamembrane" BROAD [] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0009899 name: ent-kaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22220] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] xref: EC:4.2.3.19 xref: KEGG_REACTION:R05092 xref: MetaCyc:4.2.3.19-RXN xref: RHEA:22220 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0009900 name: dehiscence namespace: biological_process def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] xref: Wikipedia:Dehiscence_(botany) is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0009901 name: anther dehiscence namespace: biological_process def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] is_a: GO:0009900 ! dehiscence relationship: part_of GO:0048653 ! anther development [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0019750 ! chloroplast localization is_a: GO:0051667 ! establishment of plastid localization [Term] id: GO:0009903 name: chloroplast avoidance movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] synonym: "high-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009904 name: chloroplast accumulation movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] synonym: "low-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009905 name: ent-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14841] synonym: "diterpene cyclase activity" BROAD [] synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] xref: EC:5.5.1.13 xref: KEGG_REACTION:R02068 xref: MetaCyc:5.5.1.13-RXN xref: RHEA:14841 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0009906 name: response to photoperiod, blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009637 ! response to blue light is_a: GO:0009648 ! photoperiodism [Term] id: GO:0009907 name: response to photoperiod, red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009648 ! photoperiodism is_a: GO:0010114 ! response to red light [Term] id: GO:0009908 name: flower development namespace: biological_process alt_id: GO:0048409 def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] subset: goslim_plant xref: MIPS_funcat:41.03.07 xref: MIPS_funcat:47.02.01.03 is_a: GO:0090567 ! reproductive shoot system development [Term] id: GO:0009909 name: regulation of flower development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048831 ! regulation of shoot system development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009908 ! flower development relationship: regulates GO:0009908 ! flower development [Term] id: GO:0009910 name: negative regulation of flower development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "down regulation of flower development" EXACT [] synonym: "down-regulation of flower development" EXACT [] synonym: "downregulation of flower development" EXACT [] synonym: "inhibition of flower development" NARROW [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009908 ! flower development relationship: negatively_regulates GO:0009908 ! flower development [Term] id: GO:0009911 name: positive regulation of flower development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "activation of flower development" NARROW [] synonym: "stimulation of flower development" NARROW [] synonym: "up regulation of flower development" EXACT [] synonym: "up-regulation of flower development" EXACT [] synonym: "upregulation of flower development" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009908 ! flower development relationship: positively_regulates GO:0009908 ! flower development [Term] id: GO:0009912 name: auditory receptor cell fate commitment namespace: biological_process def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] synonym: "auditory hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process alt_id: GO:0043355 def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] xref: MIPS_funcat:43.02.05 is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0008544 ! epidermis development [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009915 name: phloem sucrose loading namespace: biological_process def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] is_a: GO:0015770 ! sucrose transport is_a: GO:0110126 ! phloem loading [Term] id: GO:0009916 name: alternative oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0009917 name: sterol 5-alpha reductase activity namespace: molecular_function def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009918 name: sterol delta7 reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] synonym: "sterol delta-7 reductase activity" EXACT [] xref: MetaCyc:RXN-707 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009919 name: obsolete cytokinesis (sensu Viridiplantae) namespace: biological_process def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] comment: This term was made obsolete because its meaning was changed significantly. synonym: "cytokinesis (sensu Viridiplantae)" EXACT [] is_obsolete: true consider: GO:0000911 [Term] id: GO:0009920 name: cell plate formation involved in plant-type cell wall biogenesis namespace: biological_process def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0000919 ! cell plate assembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000919 ! cell plate assembly intersection_of: part_of GO:0009832 ! plant-type cell wall biogenesis relationship: part_of GO:0009832 ! plant-type cell wall biogenesis relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0009921 name: auxin efflux carrier complex namespace: cellular_component def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0009922 name: fatty acid elongase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN xref: Reactome:R-HSA-2046083 "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA" xref: Reactome:R-HSA-2046088 "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA" xref: Reactome:R-HSA-2046090 "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA" xref: Reactome:R-HSA-2046094 "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA" xref: Reactome:R-HSA-2046095 "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA" xref: Reactome:R-HSA-2046100 "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA" xref: Reactome:R-HSA-548800 "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA" xref: Reactome:R-HSA-548814 "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA" xref: Reactome:R-HSA-548815 "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA" xref: Reactome:R-HSA-548830 "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA" is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0009923 name: fatty acid elongase complex namespace: cellular_component def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0009924 name: octadecanal decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] synonym: "octadecanal alkane-lyase activity" EXACT [] xref: EC:4.1.99.5 xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN xref: RHEA:30415 is_a: GO:0071771 ! aldehyde decarbonylase activity [Term] id: GO:0009925 name: basal plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0016323 ! basolateral plasma membrane relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0009926 name: auxin polar transport namespace: biological_process def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] is_a: GO:0060918 ! auxin transport [Term] id: GO:0009927 name: histidine phosphotransfer kinase activity namespace: molecular_function def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] comment: Added is_a molecular transducer activity see https://github.com/geneontology/go-ontology/issues/15611 is_a: GO:0004672 ! protein kinase activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0009930 name: longitudinal side of cell surface namespace: cellular_component def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009931 name: calcium-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0010857 ! calcium-dependent protein kinase activity [Term] id: GO:0009932 name: cell tip growth namespace: biological_process def: "Growth that occurs specifically at the tip of a cell." [GOC:jid] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0009933 name: meristem structural organization namespace: biological_process def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] synonym: "meristem organisation" BROAD [] synonym: "meristem organization" BROAD [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0009934 name: regulation of meristem structural organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid] synonym: "regulation of meristem organisation" EXACT [] synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048509 ! regulation of meristem development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009933 ! meristem structural organization relationship: regulates GO:0009933 ! meristem structural organization [Term] id: GO:0009935 name: obsolete nutrient import namespace: biological_process def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. synonym: "nutrient import" EXACT [] synonym: "nutrient uptake" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0009936 name: obsolete expansin namespace: molecular_function def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "expansin" EXACT [] is_obsolete: true consider: GO:0009505 consider: GO:0016049 [Term] id: GO:0009937 name: regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] synonym: "regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009938 name: negative regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009939 name: positive regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "activation of gibberellic acid mediated signaling" NARROW [] synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009940 name: amino-terminal vacuolar sorting propeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles." [GOC:sm, PMID:10871276] is_a: GO:0010209 ! vacuolar sorting signal binding [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0009942 name: longitudinal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] synonym: "apical-basal pattern specification" EXACT [] synonym: "longitudinal axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0009943 name: adaxial/abaxial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] synonym: "adaxial/abaxial determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009955 ! adaxial/abaxial pattern specification [Term] id: GO:0009944 name: polarity specification of adaxial/abaxial axis namespace: biological_process def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009943 ! adaxial/abaxial axis specification [Term] id: GO:0009945 name: radial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009946 name: proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "proximal/distal axis determination" RELATED [GOC:dph] synonym: "proximodistal axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0009947 name: centrolateral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:dsz, GOC:tb, ISBN:0865427429] synonym: "centrolateral axis determination" RELATED [GOC:dph] synonym: "mediolateral axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0097353 ! centrolateral pattern formation [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] xref: MIPS_funcat:41.05.19.05 is_a: GO:0009798 ! axis specification relationship: part_of GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0009949 name: polarity specification of anterior/posterior axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0009950 name: dorsal/ventral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] synonym: "dorsoventral axis specification" EXACT [GOC:mah] xref: MIPS_funcat:41.05.19.07 is_a: GO:0009798 ! axis specification relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0009951 name: polarity specification of dorsal/ventral axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah] synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009953 name: dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "dorsal/ventral pattern specification" NARROW [] synonym: "dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0003002 ! regionalization [Term] id: GO:0009954 name: proximal/distal pattern formation namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "proximal/distal pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009955 name: adaxial/abaxial pattern specification namespace: biological_process def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "adaxial/abaxial pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009956 name: radial pattern formation namespace: biological_process def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "radial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009957 name: epidermal cell fate specification namespace: biological_process alt_id: GO:0043356 def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0009913 ! epidermal cell differentiation [Term] id: GO:0009958 name: positive gravitropism namespace: biological_process def: "The orientation of plant parts towards gravity." [GOC:sm] synonym: "root gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009959 name: negative gravitropism namespace: biological_process def: "The orientation of plant parts away from gravity." [GOC:sm] synonym: "shoot gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009960 name: endosperm development namespace: biological_process def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] xref: MIPS_funcat:41.03.04 xref: MIPS_funcat:47.02.01.05.02 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009961 name: response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] is_a: GO:0043200 ! response to amino acid [Term] id: GO:0009962 name: regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "regulation of flavonoid anabolism" EXACT [] synonym: "regulation of flavonoid biosynthesis" EXACT [] synonym: "regulation of flavonoid formation" EXACT [] synonym: "regulation of flavonoid synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009813 ! flavonoid biosynthetic process relationship: regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009963 name: positive regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "activation of flavonoid biosynthetic process" NARROW [] synonym: "positive regulation of flavonoid anabolism" EXACT [] synonym: "positive regulation of flavonoid biosynthesis" EXACT [] synonym: "positive regulation of flavonoid formation" EXACT [] synonym: "positive regulation of flavonoid synthesis" EXACT [] synonym: "stimulation of flavonoid biosynthetic process" NARROW [] synonym: "up regulation of flavonoid biosynthetic process" EXACT [] synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] synonym: "upregulation of flavonoid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0009962 ! regulation of flavonoid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009813 ! flavonoid biosynthetic process relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009964 name: negative regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "down regulation of flavonoid biosynthetic process" EXACT [] synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] synonym: "downregulation of flavonoid biosynthetic process" EXACT [] synonym: "inhibition of flavonoid biosynthetic process" NARROW [] synonym: "negative regulation of flavonoid anabolism" EXACT [] synonym: "negative regulation of flavonoid biosynthesis" EXACT [] synonym: "negative regulation of flavonoid formation" EXACT [] synonym: "negative regulation of flavonoid synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0009962 ! regulation of flavonoid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009813 ! flavonoid biosynthetic process relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009965 name: leaf morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007165 ! signal transduction relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007165 ! signal transduction relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007165 ! signal transduction relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009969 name: xyloglucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:sm] synonym: "xyloglucan anabolism" EXACT [] synonym: "xyloglucan biosynthesis" EXACT [] synonym: "xyloglucan formation" EXACT [] synonym: "xyloglucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0010411 ! xyloglucan metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0009970 name: cellular response to sulfate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] synonym: "cellular response to sulphate starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0009971 name: anastral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055048 ! anastral spindle assembly intersection_of: GO:0055048 ! anastral spindle assembly intersection_of: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0009972 name: cytidine deamination namespace: biological_process def: "The removal of amino group in the presence of water." [GOC:sm] is_a: GO:0006216 ! cytidine catabolic process [Term] id: GO:0009973 name: adenylyl-sulfate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "APS reductase activity" EXACT [EC:1.8.99.2] synonym: "APS-reductase" EXACT [EC:1.8.99.2] xref: EC:1.8.99.2 xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN xref: RHEA:24240 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009974 name: zeinoxanthin epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513] xref: EC:1.14.99 xref: MetaCyc:RXN-5962 is_a: GO:0072374 ! carotene epsilon hydroxylase activity [Term] id: GO:0009975 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009976 name: tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0009977 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function alt_id: GO:0015557 def: "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245, PMID:25494301] synonym: "arginine targeting transmembrane transporter activity" EXACT [] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] synonym: "twin-arginine targeting transmembrane transporter activity" EXACT [] is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0009978 name: allene oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: MetaCyc:RXN1F-19 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0009979 name: 16:0 monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307] is_a: GO:0042389 ! omega-3 fatty acid desaturase activity [Term] id: GO:0009980 name: obsolete glutamate carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamate carboxypeptidase activity" EXACT [] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] xref: EC:3.4.17.11 xref: MetaCyc:3.4.17.11-RXN is_obsolete: true replaced_by: GO:0004180 [Term] id: GO:0009982 name: pseudouridine synthase activity namespace: molecular_function alt_id: GO:0016439 def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. xref: Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs" xref: Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs" xref: Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)" xref: Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA" xref: Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA" is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0009983 name: obsolete tyrosine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "tyrosine aminopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0009984 name: obsolete adenylate forming enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. synonym: "adenylate forming enzyme activity" EXACT [] is_obsolete: true consider: GO:0046033 [Term] id: GO:0009985 name: obsolete dihydroflavonol(thiole) lyase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:tb] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "dihydroflavonol(thiole) lyase activity" EXACT [] is_obsolete: true [Term] id: GO:0009986 name: cell surface namespace: cellular_component alt_id: GO:0009928 alt_id: GO:0009929 def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. subset: goslim_pir synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0009988 name: cell-cell recognition namespace: biological_process def: "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009989 name: cell-matrix recognition namespace: biological_process def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009990 name: contact guidance namespace: biological_process def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] is_a: GO:0009989 ! cell-matrix recognition [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009992 name: cellular water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of water within a cell." [GOC:dph, GOC:tb] synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0006884 ! cell volume homeostasis is_a: GO:0030104 ! water homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0009995 name: soluble molecule recognition namespace: biological_process def: "The recognition of soluble molecules in the environment." [GOC:go_curators] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009996 name: negative regulation of cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] synonym: "down regulation of cell fate specification" EXACT [] synonym: "down-regulation of cell fate specification" EXACT [] synonym: "downregulation of cell fate specification" EXACT [] synonym: "inhibition of cell fate specification" NARROW [] synonym: "suppression of cell fate" EXACT [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0042659 ! regulation of cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001708 ! cell fate specification relationship: negatively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0009997 name: negative regulation of cardioblast cell fate specification namespace: biological_process alt_id: GO:0042687 def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "down regulation of cardioblast cell fate specification" EXACT [] synonym: "down-regulation of cardioblast cell fate specification" EXACT [] synonym: "downregulation of cardioblast cell fate specification" EXACT [] synonym: "inhibition of cardioblast cell fate specification" NARROW [] synonym: "suppression of cardioblast cell fate" EXACT [] is_a: GO:0042686 ! regulation of cardioblast cell fate specification is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000044 ! negative regulation of cardiac cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042685 ! cardioblast cell fate specification relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0009998 name: negative regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] synonym: "down regulation of retinal cone cell fate specification" EXACT [] synonym: "down-regulation of retinal cone cell fate specification" EXACT [] synonym: "downregulation of retinal cone cell fate specification" EXACT [] synonym: "inhibition of retinal cone cell fate specification" NARROW [] synonym: "negative regulation of retina cone cell fate specification" EXACT [] synonym: "suppression of retina cone cell fate" EXACT [] synonym: "suppression of retinal cone cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042673 ! regulation of retinal cone cell fate specification is_a: GO:0060226 ! negative regulation of retinal cone cell fate commitment intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042672 ! retinal cone cell fate specification relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0009999 name: negative regulation of auditory receptor cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] synonym: "down regulation of auditory receptor cell fate specification" EXACT [] synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] synonym: "downregulation of auditory receptor cell fate specification" EXACT [] synonym: "inhibition of auditory receptor cell fate specification" NARROW [] synonym: "negative regulation of auditory hair cell fate specification" EXACT [] synonym: "suppression of auditory receptor cell fate" EXACT [] synonym: "suppression of hair cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042669 ! regulation of inner ear auditory receptor cell fate specification is_a: GO:0045608 ! negative regulation of inner ear auditory receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042667 ! auditory receptor cell fate specification relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process alt_id: GO:0007404 alt_id: GO:0043360 def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] xref: MIPS_funcat:43.03.11 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0010004 name: gastrulation involving germ band extension namespace: biological_process def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001703 ! gastrulation with mouth forming first [Term] id: GO:0010005 name: cortical microtubule, transverse to long axis namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] is_a: GO:0055028 ! cortical microtubule [Term] id: GO:0010006 name: Toc complex namespace: cellular_component def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010007 name: magnesium chelatase complex namespace: cellular_component def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0010008 name: endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endosome." [GOC:mah] synonym: "endosomal membrane" EXACT [NIF_Subcellular:sao978443756] xref: NIF_Subcellular:sao978443756 is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0005768 ! endosome [Term] id: GO:0010009 name: cytoplasmic side of endosome membrane namespace: cellular_component def: "The side (leaflet) of the endosome membrane that faces the cytoplasm." [GOC:lr] synonym: "external leaflet of endosome membrane" EXACT [GOC:ab] synonym: "external side of endosome membrane" EXACT [] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0010011 name: auxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] synonym: "auxin receptor" NARROW [] is_a: GO:0042562 ! hormone binding [Term] id: GO:0010012 name: steroid 22-alpha hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0010013 name: N-1-naphthylphthalamic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0010014 name: meristem initiation namespace: biological_process def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009933 ! meristem structural organization [Term] id: GO:0010015 name: root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0048364 ! root development [Term] id: GO:0010016 name: shoot system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] synonym: "shoot morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0010017 name: red or far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb] synonym: "red or far-red light signal transduction" EXACT [GOC:signaling] synonym: "red or far-red light signalling pathway" EXACT [] synonym: "red/far red light signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0010018 name: far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "far red light signalling pathway" EXACT [] synonym: "far red signaling pathway" EXACT [GOC:tb] synonym: "far-red light signal transduction" EXACT [GOC:signaling] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071490 ! cellular response to far red light [Term] id: GO:0010019 name: chloroplast-nucleus signaling pathway namespace: biological_process def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] synonym: "chloroplast-nucleus signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission [Term] id: GO:0010021 name: amylopectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages." [ISBN:0943088399] synonym: "amylopectin anabolism" EXACT [] synonym: "amylopectin biosynthesis" EXACT [] synonym: "amylopectin formation" EXACT [] synonym: "amylopectin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:2000896 ! amylopectin metabolic process [Term] id: GO:0010022 name: meristem determinacy namespace: biological_process def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010023 name: proanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] synonym: "proanthocyanidin anabolism" EXACT [] synonym: "proanthocyanidin biosynthesis" EXACT [] synonym: "proanthocyanidin formation" EXACT [] synonym: "proanthocyanidin synthesis" EXACT [] xref: MetaCyc:PWY-641 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0010024 name: phytochromobilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] synonym: "phytochromobilin anabolism" EXACT [] synonym: "phytochromobilin biosynthesis" EXACT [] synonym: "phytochromobilin formation" EXACT [] synonym: "phytochromobilin synthesis" EXACT [] is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051202 ! phytochromobilin metabolic process [Term] id: GO:0010025 name: wax biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] synonym: "wax anabolism" EXACT [] synonym: "wax biosynthesis" EXACT [] synonym: "wax formation" EXACT [] synonym: "wax synthesis" EXACT [] xref: MetaCyc:PWY-282 is_a: GO:0010166 ! wax metabolic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process [Term] id: GO:0010026 name: trichome differentiation namespace: biological_process alt_id: GO:0048271 def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433] synonym: "trichome cell differentiation" EXACT [] xref: MIPS_funcat:43.02.05.02 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0090558 ! plant epidermis development [Term] id: GO:0010027 name: thylakoid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. synonym: "thylakoid membrane organisation" EXACT [] synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0010028 name: xanthophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] xref: MetaCyc:PWY-1141 xref: Wikipedia:Xanthophyll#Xanthophyll_cycle is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0010029 name: regulation of seed germination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] is_a: GO:1900140 ! regulation of seedling development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009845 ! seed germination relationship: regulates GO:0009845 ! seed germination [Term] id: GO:0010030 name: positive regulation of seed germination namespace: biological_process def: "Any process that activates or increase the rate of seed germination." [GOC:sm] synonym: "activation of seed germination" NARROW [] synonym: "stimulation of seed germination" NARROW [] synonym: "up regulation of seed germination" EXACT [] synonym: "up-regulation of seed germination" EXACT [] synonym: "upregulation of seed germination" EXACT [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048582 ! positive regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009845 ! seed germination relationship: positively_regulates GO:0009845 ! seed germination [Term] id: GO:0010031 name: circumnutation namespace: biological_process def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0010033 name: response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010034 name: response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010036 name: response to boron-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm] synonym: "response to boron" EXACT [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010037 name: response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] is_a: GO:0010033 ! response to organic substance is_a: GO:0072347 ! response to anesthetic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010040 name: response to iron(II) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] synonym: "response to iron(II)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010041 name: response to iron(III) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] synonym: "response to iron(III)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010042 name: response to manganese ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] synonym: "response to manganese" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010043 name: response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] synonym: "response to zinc" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010044 name: response to aluminum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] synonym: "response to aluminium ion" EXACT [] synonym: "response to aluminum" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010045 name: response to nickel cation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus." [GOC:sm] synonym: "response to nickel" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010046 name: response to mycotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:sm] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0010047 name: fruit dehiscence namespace: biological_process def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] is_a: GO:0009900 ! dehiscence [Term] id: GO:0010048 name: vernalization response namespace: biological_process def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] is_a: GO:0009409 ! response to cold [Term] id: GO:0010049 name: acquisition of plant reproductive competence namespace: biological_process def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] synonym: "acquisition of reproductive competence" BROAD [] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010050 name: vegetative phase change namespace: biological_process def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010051 name: xylem and phloem pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue pattern formation" EXACT [] is_a: GO:0003002 ! regionalization [Term] id: GO:0010052 name: guard cell differentiation namespace: biological_process def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] synonym: "stomatal cell differentiation" RELATED [] xref: MIPS_funcat:43.02.05.01 is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010053 name: root epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0090558 ! plant epidermis development [Term] id: GO:0010054 name: trichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] synonym: "trichoblast cell differentiation" EXACT [] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010055 name: atrichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010056 name: atrichoblast fate specification namespace: biological_process def: "The process involved in the specification of an atrichoblast." [GOC:tb] is_a: GO:0090628 ! plant epidermal cell fate specification relationship: part_of GO:0010055 ! atrichoblast differentiation [Term] id: GO:0010057 name: trichoblast fate specification namespace: biological_process def: "The process involved in the specification of a trichoblast." [GOC:tb] is_a: GO:0090628 ! plant epidermal cell fate specification relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0010058 name: regulation of atrichoblast fate specification namespace: biological_process def: "Any process that modulates atrichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1903888 ! regulation of plant epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010056 ! atrichoblast fate specification relationship: regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010059 name: positive regulation of atrichoblast fate specification namespace: biological_process def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] synonym: "activation of atrichoblast fate" NARROW [] synonym: "stimulation of atrichoblast fate" NARROW [] synonym: "up regulation of atrichoblast fate" EXACT [] synonym: "up-regulation of atrichoblast fate" EXACT [] synonym: "upregulation of atrichoblast fate" EXACT [] is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010056 ! atrichoblast fate specification relationship: positively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010060 name: negative regulation of atrichoblast fate specification namespace: biological_process def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] synonym: "down regulation of atrichoblast fate" EXACT [] synonym: "down-regulation of atrichoblast fate" EXACT [] synonym: "downregulation of atrichoblast fate" EXACT [] synonym: "inhibition of atrichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation is_a: GO:1905422 ! negative regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010056 ! atrichoblast fate specification relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010061 name: regulation of trichoblast fate specification namespace: biological_process def: "Any process that modulates trichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1903888 ! regulation of plant epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010057 ! trichoblast fate specification relationship: regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010062 name: negative regulation of trichoblast fate specification namespace: biological_process def: "Any process that suppresses trichoblast fate specification." [GOC:tb] synonym: "down regulation of trichoblast fate" EXACT [] synonym: "down-regulation of trichoblast fate" EXACT [] synonym: "downregulation of trichoblast fate" EXACT [] synonym: "inhibition of trichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation is_a: GO:1905422 ! negative regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010057 ! trichoblast fate specification relationship: negatively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010063 name: positive regulation of trichoblast fate specification namespace: biological_process def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] synonym: "activation of trichoblast fate" NARROW [] synonym: "stimulation of trichoblast fate" NARROW [] synonym: "up regulation of trichoblast fate" EXACT [] synonym: "up-regulation of trichoblast fate" EXACT [] synonym: "upregulation of trichoblast fate" EXACT [] is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010057 ! trichoblast fate specification relationship: positively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010064 name: embryonic shoot morphogenesis namespace: biological_process def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb] synonym: "primary shoot system morphogenesis" EXACT [] is_a: GO:0010016 ! shoot system morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010065 name: primary meristem tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] synonym: "primary meristem histogenesis" EXACT [] is_a: GO:0048508 ! embryonic meristem development [Term] id: GO:0010066 name: ground meristem histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010067 name: procambium histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010068 name: protoderm histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010069 name: zygote asymmetric cytokinesis in embryo sac namespace: biological_process def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] is_a: GO:0000281 ! mitotic cytokinesis is_a: GO:0010070 ! zygote asymmetric cell division is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division [Term] id: GO:0010071 name: root meristem specification namespace: biological_process def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb] xref: MIPS_funcat:45.02.01.02 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090421 ! embryonic meristem initiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010072 name: primary shoot apical meristem specification namespace: biological_process def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb] synonym: "embryo shoot apical meristem specification" EXACT [] xref: MIPS_funcat:45.02.01.01 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090421 ! embryonic meristem initiation relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010073 name: meristem maintenance namespace: biological_process def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0010074 name: maintenance of meristem identity namespace: biological_process alt_id: GO:0032503 def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] synonym: "maintenance of meristem cell identity" EXACT [] synonym: "meristem cell maintenance" EXACT [] is_a: GO:0019827 ! stem cell population maintenance relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010075 name: regulation of meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] synonym: "regulation of meristem size" EXACT [GOC:tb] is_a: GO:0048509 ! regulation of meristem development is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035266 ! meristem growth relationship: part_of GO:0010073 ! meristem maintenance relationship: regulates GO:0035266 ! meristem growth [Term] id: GO:0010076 name: maintenance of floral meristem identity namespace: biological_process def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010077 name: maintenance of inflorescence meristem identity namespace: biological_process def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010078 name: maintenance of root meristem identity namespace: biological_process def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010079 name: maintenance of vegetative meristem identity namespace: biological_process def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010080 name: regulation of floral meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] synonym: "regulation of floral meristem size" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0010075 ! regulation of meristem growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010451 ! floral meristem growth relationship: regulates GO:0010451 ! floral meristem growth [Term] id: GO:0010081 name: regulation of inflorescence meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048831 ! regulation of shoot system development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010450 ! inflorescence meristem growth relationship: regulates GO:0010450 ! inflorescence meristem growth [Term] id: GO:0010082 name: regulation of root meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] synonym: "regulation of root meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:2000280 ! regulation of root development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010449 ! root meristem growth relationship: part_of GO:0010015 ! root morphogenesis relationship: regulates GO:0010449 ! root meristem growth [Term] id: GO:0010083 name: regulation of vegetative meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048831 ! regulation of shoot system development is_a: GO:1905613 ! regulation of developmental vegetative growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010448 ! vegetative meristem growth relationship: regulates GO:0010448 ! vegetative meristem growth [Term] id: GO:0010084 name: specification of animal organ axis polarity namespace: biological_process def: "The process in which the polarity of an animal organ axis is specified." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0010085 name: polarity specification of proximal/distal axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009946 ! proximal/distal axis specification [Term] id: GO:0010086 name: embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010087 name: phloem or xylem histogenesis namespace: biological_process def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue development" BROAD [] synonym: "vascular tissue histogenesis" EXACT [] xref: MIPS_funcat:45.02.13 is_a: GO:0009888 ! tissue development [Term] id: GO:0010088 name: phloem development namespace: biological_process def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "phloem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010089 name: xylem development namespace: biological_process def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "xylem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010090 name: trichome morphogenesis namespace: biological_process alt_id: GO:0048272 def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] synonym: "trichome cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010026 ! trichome differentiation relationship: part_of GO:0090626 ! plant epidermis morphogenesis [Term] id: GO:0010091 name: trichome branching namespace: biological_process alt_id: GO:0048274 def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010090 ! trichome morphogenesis [Term] id: GO:0010092 name: specification of animal organ identity namespace: biological_process def: "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization relationship: part_of GO:0048645 ! animal organ formation [Term] id: GO:0010093 name: specification of floral organ identity namespace: biological_process def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090701 ! specification of plant organ identity relationship: part_of GO:0048449 ! floral organ formation [Term] id: GO:0010094 name: specification of carpel identity namespace: biological_process def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048462 ! carpel formation [Term] id: GO:0010095 name: specification of petal identity namespace: biological_process def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048451 ! petal formation [Term] id: GO:0010096 name: specification of sepal identity namespace: biological_process def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048453 ! sepal formation [Term] id: GO:0010097 name: specification of stamen identity namespace: biological_process def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048455 ! stamen formation [Term] id: GO:0010098 name: suspensor development namespace: biological_process def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010099 name: regulation of photomorphogenesis namespace: biological_process def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000030 ! regulation of response to red or far red light intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009640 ! photomorphogenesis relationship: regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010100 name: negative regulation of photomorphogenesis namespace: biological_process def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] synonym: "down regulation of photomorphogenesis" EXACT [] synonym: "down-regulation of photomorphogenesis" EXACT [] synonym: "downregulation of photomorphogenesis" EXACT [] synonym: "inhibition of photomorphogenesis" NARROW [] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009640 ! photomorphogenesis relationship: negatively_regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010101 name: post-embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0090697 ! post-embryonic plant organ morphogenesis relationship: part_of GO:0048528 ! post-embryonic root development [Term] id: GO:0010102 name: lateral root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] is_a: GO:0010101 ! post-embryonic root morphogenesis relationship: part_of GO:0048527 ! lateral root development [Term] id: GO:0010103 name: stomatal complex morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] is_a: GO:0090626 ! plant epidermis morphogenesis is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010104 name: regulation of ethylene-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction." [GOC:tb] synonym: "regulation of ethene mediated signaling pathway" EXACT [] synonym: "regulation of ethene mediated signalling pathway" EXACT [] synonym: "regulation of ethylene mediated signaling pathway" RELATED [] synonym: "regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0070297 ! regulation of phosphorelay signal transduction system intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009873 ! ethylene-activated signaling pathway relationship: regulates GO:0009873 ! ethylene-activated signaling pathway [Term] id: GO:0010105 name: negative regulation of ethylene-activated signaling pathway namespace: biological_process def: "Any process that stops or prevents ethylene (ethene) signal transduction." [GOC:tb] synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] synonym: "negative regulation of ethylene mediated signaling pathway" RELATED [] synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0010104 ! regulation of ethylene-activated signaling pathway is_a: GO:0070298 ! negative regulation of phosphorelay signal transduction system intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway relationship: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway [Term] id: GO:0010106 name: cellular response to iron ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] is_a: GO:0009267 ! cellular response to starvation relationship: part_of GO:0006879 ! cellular iron ion homeostasis [Term] id: GO:0010108 name: detection of glutamine namespace: biological_process def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "glutamine detection" EXACT [] synonym: "glutamine perception" RELATED [] synonym: "glutamine sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010109 name: regulation of photosynthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] xref: MIPS_funcat:02.30.10 is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015979 ! photosynthesis relationship: regulates GO:0015979 ! photosynthesis [Term] id: GO:0010110 name: regulation of photosynthesis, dark reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019685 ! photosynthesis, dark reaction relationship: regulates GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0010111 name: glyoxysome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] synonym: "glyoxysome organisation" EXACT [] synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007031 ! peroxisome organization is_a: GO:0009657 ! plastid organization [Term] id: GO:0010112 name: regulation of systemic acquired resistance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009627 ! systemic acquired resistance relationship: regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010113 name: negative regulation of systemic acquired resistance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] synonym: "down regulation of systemic acquired resistance" EXACT [] synonym: "down-regulation of systemic acquired resistance" EXACT [] synonym: "downregulation of systemic acquired resistance" EXACT [] synonym: "inhibition of systemic acquired resistance" NARROW [] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009627 ! systemic acquired resistance relationship: negatively_regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010114 name: response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "response to red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010115 name: regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] synonym: "regulation of abscisic acid anabolism" EXACT [] synonym: "regulation of abscisic acid biosynthesis" EXACT [] synonym: "regulation of abscisic acid formation" EXACT [] synonym: "regulation of abscisic acid synthesis" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009688 ! abscisic acid biosynthetic process relationship: regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010116 name: positive regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] synonym: "activation of abscisic acid biosynthetic process" NARROW [] synonym: "positive regulation of abscisic acid anabolism" EXACT [] synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] synonym: "positive regulation of abscisic acid formation" EXACT [] synonym: "positive regulation of abscisic acid synthesis" EXACT [] synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009688 ! abscisic acid biosynthetic process relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010117 name: photoprotection namespace: biological_process def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010118 name: stomatal movement namespace: biological_process def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0010119 name: regulation of stomatal movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010118 ! stomatal movement relationship: regulates GO:0010118 ! stomatal movement [Term] id: GO:0010120 name: camalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] synonym: "camalexin anabolism" EXACT [] synonym: "camalexin biosynthesis" EXACT [] synonym: "camalexin formation" EXACT [] synonym: "camalexin synthesis" EXACT [] xref: MetaCyc:CAMALEXIN-SYN is_a: GO:0009700 ! indole phytoalexin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052317 ! camalexin metabolic process [Term] id: GO:0010121 name: arginine catabolic process to proline via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] synonym: "arginine breakdown to proline via ornithine" EXACT [] synonym: "arginine degradation to proline via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0019493 ! arginine catabolic process to proline [Term] id: GO:0010122 name: arginine catabolic process to alanine via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] synonym: "arginine breakdown to alanine via ornithine" EXACT [] synonym: "arginine degradation to alanine via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0006522 ! alanine metabolic process is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0010123 name: acetate catabolic process to butyrate, ethanol, acetone and butanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] xref: MetaCyc:CENTFERM-PWY is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0019654 ! acetate fermentation is_a: GO:0043443 ! acetone metabolic process is_a: GO:0045733 ! acetate catabolic process is_a: GO:0071270 ! 1-butanol metabolic process [Term] id: GO:0010124 name: phenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] synonym: "phenylacetate breakdown" EXACT [] synonym: "phenylacetate catabolism" EXACT [] synonym: "phenylacetate degradation" EXACT [] xref: MetaCyc:PWY0-321 is_a: GO:0009407 ! toxin catabolic process is_a: GO:0009852 ! auxin catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0010125 name: mycothiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] synonym: "mycothiol anabolism" EXACT [] synonym: "mycothiol biosynthesis" EXACT [] synonym: "mycothiol formation" EXACT [] synonym: "mycothiol synthesis" EXACT [] xref: MetaCyc:PWY1G-0 is_a: GO:0010126 ! mycothiol metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0010126 name: mycothiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] synonym: "mycothiol metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0010127 name: mycothiol-dependent detoxification namespace: biological_process def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] xref: MetaCyc:PWY1G-1 xref: MetaCyc:PWY1G-170 is_a: GO:0098754 ! detoxification [Term] id: GO:0010128 name: benzoate catabolic process via CoA ligation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] synonym: "anaerobic benzoate breakdown" EXACT [] synonym: "anaerobic benzoate catabolic process" EXACT [] synonym: "anaerobic benzoate catabolism" EXACT [] synonym: "anaerobic benzoate degradation" EXACT [] xref: MetaCyc:PWY-283 is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0010129 name: anaerobic cyclohexane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] xref: MetaCyc:PWY-301 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010130 name: anaerobic ethylbenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] synonym: "anaerobic ethylbenzene breakdown" EXACT [] synonym: "anaerobic ethylbenzene catabolism" EXACT [] synonym: "anaerobic ethylbenzene degradation" EXACT [] xref: MetaCyc:PWY-481 is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process [Term] id: GO:0010131 name: obsolete sucrose catabolic process, using invertase or sucrose synthase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] comment: This term was made obsolete because it describes two different routes of sucrose catabolism, both of which are represented by molecular functions. synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolic process, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] xref: MetaCyc:PWY-3801 xref: MetaCyc:PWY-621 is_obsolete: true consider: GO:0004564 consider: GO:0005987 consider: GO:0016157 [Term] id: GO:0010132 name: dhurrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] synonym: "dhurrin anabolism" EXACT [] synonym: "dhurrin biosynthesis" EXACT [] synonym: "dhurrin formation" EXACT [] synonym: "dhurrin synthesis" EXACT [] xref: MetaCyc:PWY-861 is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0010133 name: proline catabolic process to glutamate namespace: biological_process alt_id: GO:0019494 def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] synonym: "proline breakdown to glutamate" EXACT [] synonym: "proline degradation to glutamate" EXACT [] synonym: "proline oxidation" RELATED [] xref: MetaCyc:PROUT-PWY xref: MetaCyc:PWY-4561 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0010134 name: sulfate assimilation via adenylyl sulfate reduction namespace: biological_process def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] xref: MetaCyc:SULFMETII-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0010135 name: ureide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] synonym: "ureide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0010136 name: ureide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] synonym: "ureide breakdown" EXACT [] synonym: "ureide catabolism" EXACT [] synonym: "ureide degradation" EXACT [] xref: MetaCyc:URDEGR-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0010137 name: ureide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] synonym: "ureide anabolism" EXACT [] synonym: "ureide biosynthesis" EXACT [] synonym: "ureide formation" EXACT [] synonym: "ureide synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0010138 name: pyrimidine ribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] xref: MetaCyc:PWY0-163 is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010139 name: pyrimidine deoxyribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] xref: MetaCyc:PWY0-181 is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010140 name: obsolete adenine, hypoxanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. synonym: "adenine, hypoxanthine and their nucleoside salvage" EXACT [] is_obsolete: true consider: GO:0006168 consider: GO:0006169 consider: GO:0006190 consider: GO:0043103 [Term] id: GO:0010141 name: obsolete guanine, xanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. synonym: "guanine, xanthine and their nucleoside salvage" EXACT [] is_obsolete: true consider: GO:0006178 consider: GO:0006179 consider: GO:0006190 consider: GO:0043103 [Term] id: GO:0010142 name: farnesyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] synonym: "Ac-MVA pathway" NARROW [PMID:14517367] synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] synonym: "isoprenoid pathway" EXACT [] xref: MetaCyc:PWY-922 is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process is_a: GO:1902767 ! isoprenoid biosynthetic process via mevalonate relationship: part_of GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0010143 name: cutin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] synonym: "cutin anabolism" EXACT [] synonym: "cutin biosynthesis" EXACT [] synonym: "cutin formation" EXACT [] synonym: "cutin synthesis" EXACT [] xref: MetaCyc:PWY-321 is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010144 name: pyridoxal phosphate biosynthetic process from pyridoxamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] synonym: "pyridoxal 5'-phosphate salvage from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] is_a: GO:0009443 ! pyridoxal 5'-phosphate salvage is_a: GO:0042818 ! pyridoxamine metabolic process [Term] id: GO:0010145 name: fructan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] synonym: "fructan metabolism" EXACT [] synonym: "levan metabolic process" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010146 name: fructan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] synonym: "fructan anabolism" EXACT [] synonym: "fructan biosynthesis" EXACT [] synonym: "fructan formation" EXACT [] synonym: "fructan synthesis" EXACT [] synonym: "levan biosynthesis" EXACT [] synonym: "levan biosynthetic process" EXACT [] xref: MetaCyc:PWY-822 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010147 name: fructan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] synonym: "fructan breakdown" EXACT [] synonym: "fructan catabolism" EXACT [] synonym: "fructan degradation" EXACT [] synonym: "levan catabolic process" EXACT [] synonym: "levan catabolism" EXACT [] xref: MetaCyc:PWY-862 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0010148 name: transpiration namespace: biological_process def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] xref: Wikipedia:Transpiration is_a: GO:0006833 ! water transport [Term] id: GO:0010149 name: obsolete senescence namespace: biological_process def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819] comment: This term was made obsolete because its name is ambiguous and it is covered by the two more specific terms: 'organ senescence ; GO:0010260' and 'cell aging ; GO:0007569'. synonym: "senescence" EXACT [] xref: MIPS_funcat:41.03.10 xref: Wikipedia:Senescence is_obsolete: true [Term] id: GO:0010150 name: leaf senescence namespace: biological_process def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] is_a: GO:0090693 ! plant organ senescence relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0010151 name: chloroplast elongation namespace: biological_process def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] is_a: GO:0009658 ! chloroplast organization [Term] id: GO:0010152 name: pollen maturation namespace: biological_process def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010153 name: obsolete polar cell elongation namespace: biological_process def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] comment: This term was made obsolete because it did not represent a process discrete from its sibling terms. synonym: "polar cell elongation" EXACT [] synonym: "polarity-dependent cell elongation" NARROW [] is_obsolete: true consider: GO:0042814 consider: GO:0042815 [Term] id: GO:0010154 name: fruit development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] xref: MIPS_funcat:41.03.08 xref: MIPS_funcat:47.02.01.04 is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010155 name: regulation of proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902600 ! proton transmembrane transport relationship: regulates GO:1902600 ! proton transmembrane transport [Term] id: GO:0010156 name: obsolete sporocyte morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] comment: This term was made obsolete because it was incorrectly defined. synonym: "sporocyte morphogenesis" EXACT [] is_obsolete: true consider: GO:0048533 [Term] id: GO:0010157 name: response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010158 name: abaxial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification [Term] id: GO:0010159 name: specification of animal organ position namespace: biological_process def: "The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ." [GOC:curators] is_a: GO:0003002 ! regionalization relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0010160 name: formation of animal organ boundary namespace: biological_process alt_id: GO:0048862 def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0048645 ! animal organ formation [Term] id: GO:0010161 name: red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "red light phototransduction" EXACT [GOC:signaling] synonym: "red light signal transduction" EXACT [GOC:signaling] synonym: "red light signalling pathway" EXACT [] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071491 ! cellular response to red light [Term] id: GO:0010162 name: seed dormancy process namespace: biological_process def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors." [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009] synonym: "seed dormancy" RELATED [] xref: Wikipedia:Seed#Seed_dormancy_and_protection is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022611 ! dormancy process is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0010431 ! seed maturation [Term] id: GO:0010164 name: response to cesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] synonym: "response to cesium" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010165 name: response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] synonym: "response to X-ray radiation stimulus" EXACT [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010166 name: wax metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] synonym: "wax metabolism" EXACT [] is_a: GO:1901568 ! fatty acid derivative metabolic process [Term] id: GO:0010167 name: response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010168 name: ER body namespace: cellular_component def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] synonym: "endoplasmic reticulum body" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0010169 name: thioglucosidase complex namespace: cellular_component def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] synonym: "myrosinase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0010170 name: glucose-1-phosphate adenylyltransferase complex namespace: cellular_component def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] is_a: GO:1902503 ! adenylyltransferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0010172 name: embryonic body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems] is_a: GO:0010171 ! body morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010174 name: nucleoside transmembrane transporter activity, against a concentration gradient namespace: molecular_function def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] synonym: "concentrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0010176 name: homogentisate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521] xref: KEGG_REACTION:R07500 xref: MetaCyc:RXN-2541 is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010177 name: 2-(2'-methylthio)ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+." [MetaCyc:RXN-2202] synonym: "methylthioalkylmalate synthase activity" BROAD [MetaCyc:RXN-2202] xref: EC:2.3.3.17 xref: MetaCyc:RXN-2202 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0010178 name: IAA-amino acid conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0010179 name: IAA-Ala conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981] xref: MetaCyc:RXN-2981 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010180 name: thioglucosidase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb] synonym: "myrosinase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0010181 name: FMN binding namespace: molecular_function def: "Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] synonym: "flavin mononucleotide binding" EXACT [] xref: MIPS_funcat:16.21.05 is_a: GO:0032553 ! ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0010182 name: sugar mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] synonym: "sugar mediated signalling" EXACT [] is_a: GO:0009756 ! carbohydrate mediated signaling [Term] id: GO:0010183 name: pollen tube guidance namespace: biological_process def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] is_a: GO:0022414 ! reproductive process is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0010184 name: cytokinin transport namespace: biological_process def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr] is_a: GO:0009914 ! hormone transport [Term] id: GO:0010185 name: regulation of cellular defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "regulation of cellular defence response" EXACT [] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006968 ! cellular defense response relationship: regulates GO:0006968 ! cellular defense response [Term] id: GO:0010186 name: positive regulation of cellular defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "activation of cellular defense response" NARROW [] synonym: "positive regulation of cellular defence response" EXACT [] synonym: "stimulation of cellular defense response" NARROW [] synonym: "up regulation of cellular defense response" EXACT [] synonym: "up-regulation of cellular defense response" EXACT [] synonym: "upregulation of cellular defense response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031349 ! positive regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006968 ! cellular defense response relationship: positively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0010187 name: negative regulation of seed germination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb] synonym: "down regulation of seed germination" EXACT [] synonym: "down-regulation of seed germination" EXACT [] synonym: "downregulation of seed germination" EXACT [] synonym: "inhibition of seed germination" NARROW [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048581 ! negative regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009845 ! seed germination relationship: negatively_regulates GO:0009845 ! seed germination [Term] id: GO:0010188 name: response to microbial phytotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0010189 name: vitamin E biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] synonym: "alpha-tocopherol biosynthesis" NARROW [] synonym: "alpha-tocopherol biosynthetic process" NARROW [] synonym: "tocopherol biosynthesis" EXACT [] synonym: "tocopherol biosynthetic process" EXACT [] synonym: "vitamin E anabolism" EXACT [] synonym: "vitamin E biosynthesis" EXACT [] synonym: "vitamin E formation" EXACT [] synonym: "vitamin E synthesis" EXACT [] xref: MetaCyc:PWY-1422 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042360 ! vitamin E metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0010190 name: cytochrome b6f complex assembly namespace: biological_process def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] synonym: "cytochrome b6f complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0010191 name: mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] subset: goslim_pir synonym: "mucilage metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0010192 name: mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] synonym: "mucilage anabolism" EXACT [] synonym: "mucilage biosynthesis" EXACT [] synonym: "mucilage formation" EXACT [] synonym: "mucilage synthesis" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0010193 name: response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0010194 name: obsolete microRNA metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it implies further processing of an end product rather than its production. synonym: "microRNA metabolic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010195 name: obsolete microRNA biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it represents a process that is not known to occur. synonym: "microRNA anabolism" EXACT [] synonym: "microRNA biosynthesis" EXACT [] synonym: "microRNA biosynthetic process" EXACT [] synonym: "microRNA formation" EXACT [] synonym: "microRNA synthesis" EXACT [] synonym: "miRNA biosynthesis" EXACT [] synonym: "miRNA biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010196 name: nonphotochemical quenching namespace: biological_process def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783, PMID:10938857] is_a: GO:1990066 ! energy quenching [Term] id: GO:0010197 name: polar nucleus fusion namespace: biological_process def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0010198 name: synergid death namespace: biological_process alt_id: GO:0048470 def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] synonym: "synergid cell death" EXACT [] synonym: "synergid degeneration" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010199 name: organ boundary specification between lateral organs and the meristem namespace: biological_process def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] is_a: GO:0090691 ! formation of plant organ boundary [Term] id: GO:0010200 name: response to chitin namespace: biological_process def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010201 name: response to continuous far red light stimulus by the high-irradiance response system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010218 ! response to far red light [Term] id: GO:0010202 name: response to low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0010114 ! response to red light [Term] id: GO:0010203 name: response to very low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010114 ! response to red light is_a: GO:0055122 ! response to very low light intensity stimulus [Term] id: GO:0010204 name: defense response signaling pathway, resistance gene-independent namespace: biological_process def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm] synonym: "defence response signaling pathway, resistance gene-independent" EXACT [] synonym: "defence response signalling pathway, resistance gene-independent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0010205 name: photoinhibition namespace: biological_process def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] synonym: "photosystem II inhibition" BROAD [] xref: Wikipedia:Photoinhibition is_a: GO:0009644 ! response to high light intensity is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0010206 name: photosystem II repair namespace: biological_process def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition." [GOC:sm] is_a: GO:0030091 ! protein repair relationship: part_of GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0010207 name: photosystem II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms." [GOC:aa, GOC:pz] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0010208 name: pollen wall assembly namespace: biological_process def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0045229 ! external encapsulating structure organization relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010209 name: vacuolar sorting signal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0010210 name: IAA-Phe conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr] is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010211 name: IAA-Leu conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982] xref: MetaCyc:RXN-2982 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation [Term] id: GO:0010213 name: non-photoreactive DNA repair namespace: biological_process def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] synonym: "light-independent DNA repair" EXACT [GOC:syr] is_a: GO:0006281 ! DNA repair [Term] id: GO:0010214 name: seed coat development namespace: biological_process def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010215 name: cellulose microfibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730] synonym: "cellulose microfibril organisation" EXACT [] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0071668 ! plant-type cell wall assembly [Term] id: GO:0010216 name: maintenance of DNA methylation namespace: biological_process def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0006306 ! DNA methylation [Term] id: GO:0010217 name: cellular aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah] synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055079 ! aluminum ion homeostasis [Term] id: GO:0010218 name: response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] synonym: "response to far red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010219 name: regulation of vernalization response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010048 ! vernalization response relationship: regulates GO:0010048 ! vernalization response [Term] id: GO:0010220 name: positive regulation of vernalization response namespace: biological_process def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "activation of vernalization response" NARROW [] synonym: "stimulation of vernalization response" NARROW [] synonym: "up regulation of vernalization response" EXACT [] synonym: "up-regulation of vernalization response" EXACT [] synonym: "upregulation of vernalization response" EXACT [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010048 ! vernalization response relationship: positively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010221 name: negative regulation of vernalization response namespace: biological_process def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "down regulation of vernalization response" EXACT [] synonym: "down-regulation of vernalization response" EXACT [] synonym: "downregulation of vernalization response" EXACT [] synonym: "inhibition of vernalization response" NARROW [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010048 ! vernalization response relationship: negatively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010222 name: stem vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010223 name: secondary shoot formation namespace: biological_process def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] synonym: "auxiliary shoot formation" RELATED [] synonym: "axillary shoot formation" RELATED [] synonym: "axillary shoot system formation" EXACT [] synonym: "shoot branching" RELATED [] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0010346 ! shoot axis formation [Term] id: GO:0010224 name: response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] synonym: "response to medium wave ultraviolet light stimulus" EXACT [] synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-B light stimulus" EXACT [] synonym: "response to UV-B radiation stimulus" EXACT [] synonym: "response to UVB light stimulus" EXACT [] synonym: "response to UVB radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010225 name: response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb] synonym: "response to germicidal ultraviolet light stimulus" EXACT [] synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] synonym: "response to shortwave ultraviolet light stimulus" EXACT [] synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-C light stimulus" EXACT [] synonym: "response to UV-C radiation stimulus" EXACT [] synonym: "response to UVC light stimulus" EXACT [] synonym: "response to UVC radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010226 name: response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010227 name: floral organ abscission namespace: biological_process def: "The controlled shedding of floral organs." [GOC:PO_curators, PMID:12972671, PO:0025395] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009838 ! abscission relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0010228 name: vegetative to reproductive phase transition of meristem namespace: biological_process def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] synonym: "flowering" RELATED [] synonym: "transition from vegetative to reproductive phase" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009791 ! post-embryonic development relationship: part_of GO:0048608 ! reproductive structure development [Term] id: GO:0010229 name: inflorescence development namespace: biological_process def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0090567 ! reproductive shoot system development [Term] id: GO:0010230 name: alternative respiration namespace: biological_process def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] is_a: GO:0009060 ! aerobic respiration [Term] id: GO:0010231 name: maintenance of seed dormancy namespace: biological_process def: "Any process that maintains a seed in a dormant state." [ISBN:9781405139830, PMID:9580097] is_a: GO:0010162 ! seed dormancy process is_a: GO:0097437 ! maintenance of dormancy [Term] id: GO:0010232 name: vascular transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010233 name: phloem transport namespace: biological_process def: "The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues." [GOC:sm, PMID:19025382] is_a: GO:0010232 ! vascular transport [Term] id: GO:0010234 name: anther wall tapetum cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] synonym: "tapetal cell fate specification" BROAD [GOC:tb] is_a: GO:0001708 ! cell fate specification is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0048657 ! anther wall tapetum cell differentiation [Term] id: GO:0010235 name: guard mother cell cytokinesis namespace: biological_process def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] synonym: "guard mother cell division" EXACT [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010236 name: plastoquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] synonym: "plastoquinone anabolism" EXACT [] synonym: "plastoquinone biosynthesis" EXACT [] synonym: "plastoquinone formation" EXACT [] synonym: "plastoquinone synthesis" EXACT [] xref: MetaCyc:PWY-1581 is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0010238 name: response to proline namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid [Term] id: GO:0010239 name: chloroplast mRNA processing namespace: biological_process def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] is_a: GO:0006397 ! mRNA processing is_a: GO:0031425 ! chloroplast RNA processing intersection_of: GO:0006397 ! mRNA processing intersection_of: occurs_in GO:0009507 ! chloroplast relationship: occurs_in GO:0009507 ! chloroplast [Term] id: GO:0010240 name: plastid pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] synonym: "dehydrogenase complex" BROAD [] is_a: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0010241 name: ent-kaurene oxidation to kaurenoic acid namespace: biological_process def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [GOC:tb] comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions. synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT [] synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT [] synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT [] is_a: GO:0033331 ! ent-kaurene metabolic process is_a: GO:0055114 ! oxidation-reduction process relationship: has_part GO:0052615 ! ent-kaurene oxidase activity relationship: has_part GO:0052616 ! ent-kaur-16-en-19-ol oxidase activity relationship: has_part GO:0052617 ! ent-kaur-16-en-19-al oxidase activity [Term] id: GO:0010242 name: oxygen evolving activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] synonym: "photosynthetic water oxidation" EXACT [] xref: MetaCyc:PSII-RXN xref: MetaCyc:RXN0-5265 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0010243 name: response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419] synonym: "response to organic nitrogen" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0010244 name: response to low fluence blue light stimulus by blue low-fluence system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] synonym: "response to low fluence blue light" BROAD [] synonym: "response to low fluence blue light by blf system" EXACT [] is_a: GO:0009637 ! response to blue light is_a: GO:0009645 ! response to low light intensity stimulus [Term] id: GO:0010245 name: radial microtubular system formation namespace: biological_process def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0010246 name: rhamnogalacturonan I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] synonym: "rhamnogalacturonan I anabolism" EXACT [] synonym: "rhamnogalacturonan I biosynthesis" EXACT [] synonym: "rhamnogalacturonan I formation" EXACT [] synonym: "rhamnogalacturonan I synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010247 name: detection of phosphate ion namespace: biological_process def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "phosphate ion detection" EXACT [] synonym: "phosphate ion perception" RELATED [] synonym: "phosphate ion sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010248 name: establishment or maintenance of transmembrane electrochemical gradient namespace: biological_process def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm] is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0010249 name: auxin conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] synonym: "auxin conjugate metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process [Term] id: GO:0010250 name: S-methylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] synonym: "S-methylmethionine anabolism" EXACT [] synonym: "S-methylmethionine biosynthesis" EXACT [] synonym: "S-methylmethionine formation" EXACT [] synonym: "S-methylmethionine synthesis" EXACT [] is_a: GO:0033477 ! S-methylmethionine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0010252 name: auxin homeostasis namespace: biological_process def: "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010253 name: UDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] synonym: "UDP-rhamnose anabolism" EXACT [] synonym: "UDP-rhamnose biosynthesis" EXACT [] synonym: "UDP-rhamnose formation" EXACT [] synonym: "UDP-rhamnose synthesis" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033478 ! UDP-rhamnose metabolic process [Term] id: GO:0010254 name: nectary development namespace: biological_process def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010255 name: glucose mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] synonym: "glucose mediated signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling relationship: part_of GO:0071333 ! cellular response to glucose stimulus [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0010257 name: NADH dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010258 name: NADH dehydrogenase complex (plastoquinone) assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] is_a: GO:0010257 ! NADH dehydrogenase complex assembly is_a: GO:0010275 ! NAD(P)H dehydrogenase complex assembly [Term] id: GO:0010259 name: multicellular organism aging namespace: biological_process def: "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] is_a: GO:0007275 ! multicellular organism development is_a: GO:0007568 ! aging [Term] id: GO:0010260 name: animal organ senescence namespace: biological_process alt_id: GO:0010261 def: "The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb] is_a: GO:0007568 ! aging relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0010262 name: somatic embryogenesis namespace: biological_process def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] is_a: GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010263 name: tricyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0010264 name: myo-inositol hexakisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538] synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] synonym: "myo-inositol hexakisphosphate formation" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] synonym: "phytate biosynthesis" EXACT [] synonym: "phytate biosynthetic process" EXACT [] is_a: GO:0032958 ! inositol phosphate biosynthetic process is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process [Term] id: GO:0010265 name: SCF complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0010266 name: response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] synonym: "response to thiamin" EXACT [] synonym: "response to thiamine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug [Term] id: GO:0010267 name: production of ta-siRNAs involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah] is_a: GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0010268 name: brassinosteroid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0010269 name: response to selenium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010270 name: photosystem II oxygen evolving complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ." [GOC:aa, PMID:16282331] synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] is_a: GO:0010207 ! photosystem II assembly [Term] id: GO:0010271 name: regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] is_a: GO:0090056 ! regulation of chlorophyll metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015996 ! chlorophyll catabolic process relationship: regulates GO:0015996 ! chlorophyll catabolic process [Term] id: GO:0010272 name: response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010273 name: detoxification of copper ion namespace: biological_process def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [GOC:kmv, PMID:16367966] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:1990169 ! stress response to copper ion [Term] id: GO:0010274 name: hydrotropism namespace: biological_process def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] xref: Wikipedia:Hydrotropism is_a: GO:0009606 ! tropism [Term] id: GO:0010275 name: NAD(P)H dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010276 name: phytol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683] xref: EC:2.7.1 xref: MetaCyc:RXN-7683 is_a: GO:0016301 ! kinase activity [Term] id: GO:0010277 name: chlorophyllide a oxygenase [overall] activity namespace: molecular_function alt_id: GO:0046407 def: "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] comment: This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'. synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll a oxygenation activity" EXACT [] synonym: "chlorophyll b synthesis activity" EXACT [] synonym: "chlorophyll-b synthesis activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenation activity" EXACT [EC:1.13.12.14] xref: EC:1.14.13.122 xref: RHEA:30359 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0010278 name: chloroplast outer membrane translocon namespace: cellular_component def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010279 name: indole-3-acetic acid amido synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623] synonym: "IAA amido synthetase activity" EXACT [] synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad] synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0010280 name: UDP-L-rhamnose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918] synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] xref: MetaCyc:RXN-5482 is_a: GO:0016740 ! transferase activity [Term] id: GO:0010282 name: senescence-associated vacuole namespace: cellular_component def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] synonym: "senescence associated vacuole" EXACT [] is_a: GO:0000323 ! lytic vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0010283 name: pinoresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8678 xref: MetaCyc:RXN-8683 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010284 name: lariciresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8679 xref: MetaCyc:RXN-8684 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010285 name: L,L-diaminopimelate aminotransferase activity namespace: molecular_function alt_id: GO:0043742 def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+)." [EC:2.6.1.83, RHEA:23988] synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] xref: EC:2.6.1.83 xref: KEGG_REACTION:R07613 xref: MetaCyc:RXN-7737 xref: RHEA:23988 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010286 name: heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] synonym: "thermotolerance" RELATED [GOC:tb] is_a: GO:0009408 ! response to heat [Term] id: GO:0010287 name: plastoglobule namespace: cellular_component alt_id: GO:0010502 def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] synonym: "PG" EXACT [] synonym: "plastoglobuli" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0010288 name: response to lead ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010289 name: homogalacturonan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] xref: MetaCyc:PWY-1061 is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0052325 ! cell wall pectin biosynthetic process [Term] id: GO:0010290 name: chlorophyll catabolite transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other." [PMID:9681016] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0010291 name: carotene beta-ring hydroxylase activity namespace: molecular_function alt_id: GO:0042411 def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736] synonym: "beta-carotene hydroxylase activity" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0010292 name: GTP:GDP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0010293 name: abscisic aldehyde oxidase activity namespace: molecular_function alt_id: GO:0033725 def: "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+)." [EC:1.2.3.14, RHEA:20529] synonym: "AAO3" RELATED [EC:1.2.3.14] synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] synonym: "AOdelta" RELATED [EC:1.2.3.14] xref: EC:1.2.3.14 xref: KEGG_REACTION:R06957 xref: MetaCyc:1.2.3.14-RXN xref: RHEA:20529 is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0010294 name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: MetaCyc:RXN-8155 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0010295 name: (+)-abscisic acid 8'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+)." [EC:1.14.14.137, RHEA:12897] synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.14.137] synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.14.137] synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.14.137] synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] xref: EC:1.14.14.137 xref: KEGG_REACTION:R07202 xref: MetaCyc:1.14.13.93-RXN xref: RHEA:12897 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0010296 name: prenylcysteine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359] xref: EC:3.1.1 xref: MetaCyc:RXN-8409 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0010297 name: heteropolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with heteropolysaccharides. A heteropolysaccharide is a glycan composed of more than one type of monosaccharide residue." [PMID:16640603] synonym: "heteroglycan binding" EXACT [] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0010298 name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671] xref: MetaCyc:RXN-8275 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0010299 name: detoxification of cobalt ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:0032025 ! response to cobalt ion [Term] id: GO:0010301 name: xanthoxin dehydrogenase activity namespace: molecular_function alt_id: GO:0033710 def: "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH." [EC:1.1.1.288, RHEA:12548] synonym: "ABA2" RELATED [EC:1.1.1.288] synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] xref: EC:1.1.1.288 xref: KEGG_REACTION:R06954 xref: MetaCyc:1.1.1.288-RXN xref: RHEA:12548 is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity [Term] id: GO:0010303 name: limit dextrinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] synonym: "R-enzyme" RELATED [EC:3.2.1.142] xref: EC:3.2.1.142 xref: MetaCyc:3.2.1.10-RXN xref: MetaCyc:3.2.1.142-RXN xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0010304 name: PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880] synonym: "LHCII catabolism" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0010305 name: leaf vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010306 name: rhamnogalacturonan II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process is_a: GO:0052325 ! cell wall pectin biosynthetic process [Term] id: GO:0010307 name: acetylglutamate kinase regulator activity namespace: molecular_function def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] is_a: GO:0019207 ! kinase regulator activity relationship: regulates GO:0003991 ! acetylglutamate kinase activity [Term] id: GO:0010308 name: acireductone dioxygenase (Ni2+-requiring) activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14161] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "ARD activity" RELATED [EC:1.13.11.53] synonym: "E-2 activity" RELATED [EC:1.13.11.53] xref: EC:1.13.11.53 xref: KEGG_REACTION:R07363 xref: MetaCyc:R146-RXN xref: RHEA:14161 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010309 name: acireductone dioxygenase [iron(II)-requiring] activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24504] synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] synonym: "aci-reductone dioxygenase" BROAD [] synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] synonym: "ARD'" RELATED [] synonym: "ARD1" RELATED [] synonym: "E-2'" RELATED [] xref: EC:1.13.11.54 xref: KEGG_REACTION:R07364 xref: MetaCyc:R147-RXN xref: Reactome:R-HSA-1237119 "Acireductone is oxidized to MOB" xref: RHEA:24504 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010310 name: regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] synonym: "regulation of hydrogen peroxide metabolism" EXACT [] is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042743 ! hydrogen peroxide metabolic process relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010311 name: lateral root formation namespace: biological_process alt_id: GO:0010386 def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators, PMID:17259263] synonym: "lateral root primordium development" EXACT [] is_a: GO:0009791 ! post-embryonic development is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010102 ! lateral root morphogenesis [Term] id: GO:0010312 name: detoxification of zinc ion namespace: biological_process def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] is_a: GO:0098754 ! detoxification relationship: part_of GO:1990359 ! stress response to zinc ion [Term] id: GO:0010313 name: phytochrome binding namespace: molecular_function def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102] is_a: GO:0005515 ! protein binding [Term] id: GO:0010314 name: phosphatidylinositol-5-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0010315 name: auxin efflux namespace: biological_process def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators, PMID:16990790] synonym: "auxin export" EXACT [] is_a: GO:0010928 ! regulation of auxin mediated signaling pathway is_a: GO:0060918 ! auxin transport [Term] id: GO:0010316 name: pyrophosphate-dependent phosphofructokinase complex namespace: cellular_component def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] subset: goslim_pir synonym: "PFK complex" RELATED [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0010317 name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex namespace: cellular_component def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, alpha-subunit" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010318 name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex namespace: cellular_component def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, beta-subunit" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010319 name: stromule namespace: cellular_component def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] synonym: "Stroma-filled tubule" RELATED [] xref: Wikipedia:Stromule is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0010320 name: obsolete arginine/lysine endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. synonym: "arginine/lysine endopeptidase activity" EXACT [] is_obsolete: true consider: GO:0004175 consider: GO:0004197 [Term] id: GO:0010321 name: regulation of vegetative phase change namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010050 ! vegetative phase change relationship: regulates GO:0010050 ! vegetative phase change [Term] id: GO:0010322 name: regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [Term] id: GO:0010323 name: negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] synonym: "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [Term] id: GO:0010324 name: membrane invagination namespace: biological_process alt_id: GO:1902534 def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization created_by: jl creation_date: 2013-12-02T13:58:34Z [Term] id: GO:0010325 name: raffinose family oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process [Term] id: GO:0010326 name: methionine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid." [MetaCyc:RXN-2201, PMID:17056707] xref: MetaCyc:RXN-2201 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010327 name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] synonym: "hexenol acetyltransferase" RELATED [] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0010328 name: auxin influx transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] synonym: "auxin influx facilitator" RELATED [] is_a: GO:0080161 ! auxin transmembrane transporter activity relationship: part_of GO:0060919 ! auxin influx [Term] id: GO:0010329 name: auxin efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] synonym: "auxin efflux carrier" RELATED [] synonym: "auxin efflux facilitator" RELATED [] is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity relationship: part_of GO:0010315 ! auxin efflux [Term] id: GO:0010330 name: cellulose synthase complex namespace: cellular_component def: "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238, PMID:18485800, PMID:21307367] synonym: "CESA complex" EXACT [] is_a: GO:1990234 ! transferase complex [Term] id: GO:0010331 name: gibberellin binding namespace: molecular_function def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] synonym: "gibberellic acid receptor" RELATED [] synonym: "gibberellin receptor" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010333 name: terpene synthase activity namespace: molecular_function def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0010334 name: sesquiterpene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0010335 name: response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0010336 name: gibberellic acid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] synonym: "gibberellin homeostasis" BROAD [] is_a: GO:0055081 ! anion homeostasis is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0010337 name: regulation of salicylic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] synonym: "regulation of salicylic acid metabolism" RELATED [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009696 ! salicylic acid metabolic process relationship: regulates GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010338 name: leaf formation namespace: biological_process def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0099402 ! plant organ development is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010339 name: external side of cell wall namespace: cellular_component def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005618 ! cell wall relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0010340 name: carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0010341 name: gibberellin carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester." [PMID:17220201] is_a: GO:0010340 ! carboxyl-O-methyltransferase activity [Term] id: GO:0010342 name: endosperm cellularization namespace: biological_process def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] synonym: "cellularization of endosperm" EXACT [] is_a: GO:0007349 ! cellularization [Term] id: GO:0010343 name: singlet oxygen-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:17075038] synonym: "light-dependent programmed cell death" BROAD [] synonym: "programmed cell death in response to singlet oxygen" EXACT [] is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species relationship: part_of GO:0071452 ! cellular response to singlet oxygen [Term] id: GO:0010344 name: seed oilbody biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495] synonym: "oleosome biogenesis" RELATED [] synonym: "seed oil body organization" EXACT [] synonym: "spherosome biogenesis" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:0044085 ! cellular component biogenesis relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010345 name: suberin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] xref: MetaCyc:PWY-1121 is_a: GO:0009699 ! phenylpropanoid biosynthetic process [Term] id: GO:0010346 name: shoot axis formation namespace: biological_process def: "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] synonym: "shoot formation" RELATED [] is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010016 ! shoot system morphogenesis [Term] id: GO:0010347 name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: MetaCyc:RXNQT-4142 is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0010348 name: lithium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] synonym: "lithium:hydrogen antiporter activity" EXACT [] is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0010349 name: L-galactose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: MetaCyc:RXN-1884 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0010350 name: cellular response to magnesium starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010351 name: lithium ion transport namespace: biological_process def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011] synonym: "lithium transport" EXACT [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0010352 name: lithium ion export across the plasma membrane namespace: biological_process def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] synonym: "lithium export" EXACT [] synonym: "lithium ion efflux" RELATED [] synonym: "lithium ion export" RELATED [] is_a: GO:0010351 ! lithium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport is_a: GO:0140115 ! export across plasma membrane [Term] id: GO:0010353 name: response to trehalose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] synonym: "response to trehalose stimulus" EXACT [GOC:dos] is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0010354 name: homogentisate prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0010355 name: homogentisate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010356 name: homogentisate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010357 name: homogentisate solanesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010358 name: leaf shaping namespace: biological_process def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] synonym: "leaf structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010359 name: regulation of anion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005253 ! anion channel activity relationship: regulates GO:0005253 ! anion channel activity [Term] id: GO:0010360 name: negative regulation of anion channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1903960 ! negative regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005253 ! anion channel activity relationship: negatively_regulates GO:0005253 ! anion channel activity [Term] id: GO:0010361 name: regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010359 ! regulation of anion channel activity [Term] id: GO:0010362 name: negative regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] synonym: "inhibition by blue light of anion channel activity" NARROW [] synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:0010361 ! regulation of anion channel activity by blue light [Term] id: GO:0010363 name: regulation of plant-type hypersensitive response namespace: biological_process def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "regulation of HR" EXACT [] synonym: "regulation of HR-PCD" EXACT [] synonym: "regulation of plant hypersensitive response" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009626 ! plant-type hypersensitive response relationship: regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0010364 name: regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009693 ! ethylene biosynthetic process relationship: regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010365 name: positive regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009693 ! ethylene biosynthetic process relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010366 name: negative regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009693 ! ethylene biosynthetic process relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010367 name: extracellular isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] is_a: GO:0043033 ! isoamylase complex intersection_of: GO:0043033 ! isoamylase complex intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0010368 name: chloroplast isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] is_a: GO:0043033 ! isoamylase complex intersection_of: GO:0043033 ! isoamylase complex intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0010369 name: chromocenter namespace: cellular_component def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] is_a: GO:0098687 ! chromosomal region [Term] id: GO:0010370 name: perinucleolar chromocenter namespace: cellular_component def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] is_a: GO:0010369 ! chromocenter [Term] id: GO:0010371 name: regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009686 ! gibberellin biosynthetic process relationship: regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010372 name: positive regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009686 ! gibberellin biosynthetic process relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010373 name: negative regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009686 ! gibberellin biosynthetic process relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010374 name: stomatal complex development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0009791 ! post-embryonic development is_a: GO:0090558 ! plant epidermis development [Term] id: GO:0010375 name: stomatal complex patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0003002 ! regionalization [Term] id: GO:0010376 name: stomatal complex formation namespace: biological_process def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010377 name: guard cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] synonym: "stomatal cell fate commitment" RELATED [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010378 name: temperature compensation of the circadian clock namespace: biological_process def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] synonym: "regulation of the circadian clock by temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0010379 name: phaseic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271] xref: MetaCyc:PWY-5271 is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0010380 name: regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] is_a: GO:0090056 ! regulation of chlorophyll metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015995 ! chlorophyll biosynthetic process relationship: regulates GO:0015995 ! chlorophyll biosynthetic process [Term] id: GO:0010381 name: peroxisome-chloroplast membrane tethering namespace: biological_process def: "The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:17215364] synonym: "attachment of peroxisome to chloroplast" EXACT [] is_a: GO:0140056 ! organelle localization by membrane tethering [Term] id: GO:0010383 name: cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010384 name: cell wall proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010385 name: double-stranded methylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0010387 name: COP9 signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927] synonym: "signalosome assembly" BROAD [GOC:krc] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010389 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] synonym: "regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010390 name: histone monoubiquitination namespace: biological_process def: "The modification of histones by addition of a single ubiquitin group." [PMID:17329563] is_a: GO:0006513 ! protein monoubiquitination is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0010391 name: glucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] synonym: "glucomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0010392 name: galactoglucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] synonym: "galactoglucomannan metabolism" RELATED [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010393 name: galacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] synonym: "galacturonan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0010394 name: homogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] synonym: "homogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010395 name: rhamnogalacturonan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] synonym: "RGI metabolism" RELATED [] synonym: "rhamnogalacturonan I metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010396 name: rhamnogalacturonan II metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010397 name: apiogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] synonym: "apiogalacturonan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0010398 name: xylogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] synonym: "xylogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010399 name: rhamnogalacturonan I backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010400 name: rhamnogalacturonan I side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010401 name: pectic galactan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic galactan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010402 name: pectic arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010403 name: pectic arabinogalactan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinogalactan I metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010404 name: cell wall hydroxyproline-rich glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] is_a: GO:0010384 ! cell wall proteoglycan metabolic process [Term] id: GO:0010405 name: arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] synonym: "arabinogalactan protein metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010406 name: classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] synonym: "classical-arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010407 name: non-classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] synonym: "non-classical arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010408 name: fasciclin-like arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010409 name: extensin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] synonym: "extensin metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010410 name: hemicellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] synonym: "hemicellulose metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010411 name: xyloglucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] synonym: "xyloglucan metabolism" EXACT [GOC:obol] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0010412 name: mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] synonym: "mannan metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010413 name: glucuronoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] synonym: "glucuronoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010414 name: glucuronoarabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] synonym: "glucuronoarabinoxylan metabolism" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process [Term] id: GO:0010415 name: unsubstituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] synonym: "unsubstituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0010416 name: arabinoxylan-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] synonym: "arabinoxylan metabolic process" RELATED [] synonym: "arabinoxylan metabolism" RELATED [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010417 name: glucuronoxylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] synonym: "glucuronoxylan anabolism" EXACT [] synonym: "glucuronoxylan biosynthesis" EXACT [] synonym: "glucuronoxylan formation" EXACT [] synonym: "glucuronoxylan synthesis" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0045492 ! xylan biosynthetic process [Term] id: GO:0010418 name: rhamnogalacturonan II backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010419 name: rhamnogalacturonan II side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010420 name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity namespace: molecular_function alt_id: GO:1990886 def: "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.114, PMID:10419476, RHEA:44452] {comment="PMID:9628017"} synonym: "polyprenyldihydroxybenzoate methyltransferase activity" RELATED [] xref: EC:2.1.1.114 xref: MetaCyc:RXN-9281 xref: RHEA:44452 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: sl creation_date: 2015-10-28T22:12:58Z [Term] id: GO:0010421 name: hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:16036580] synonym: "programmed cell death in response to hydrogen peroxide" EXACT [] is_a: GO:0036474 ! cell death in response to hydrogen peroxide is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species [Term] id: GO:0010422 name: regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016132 ! brassinosteroid biosynthetic process relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010423 name: negative regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010424 name: DNA methylation on cytosine within a CG sequence namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010425 name: DNA methylation on cytosine within a CNG sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010426 name: DNA methylation on cytosine within a CHH sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600] synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah] synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010427 name: abscisic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] synonym: "ABA binding" RELATED [] synonym: "abscisate binding" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0042562 ! hormone binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0010428 name: methyl-CpNpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010429 name: methyl-CpNpN binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010430 name: fatty acid omega-oxidation namespace: biological_process def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574] xref: MetaCyc:PWY-2724 is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0010431 name: seed maturation namespace: biological_process def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048609 ! multicellular organismal reproductive process is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010432 name: bract development namespace: biological_process def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048827 ! phyllome development [Term] id: GO:0010433 name: bract morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0010432 ! bract development [Term] id: GO:0010434 name: bract formation namespace: biological_process def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010433 ! bract morphogenesis [Term] id: GO:0010435 name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437] synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695] synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT [] synonym: "OPC-8:0 CoA ligase activity" EXACT [] xref: EC:6.2.1 xref: MetaCyc:RXN-10695 is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0010436 name: carotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] synonym: "carotenoid-cleaving dioxygenase" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010437 name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0010438 name: cellular response to sulfur starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010439 name: regulation of glucosinolate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019761 ! glucosinolate biosynthetic process relationship: regulates GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0010440 name: stomatal lineage progression namespace: biological_process def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010441 name: guard cell development namespace: biological_process def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010442 name: guard cell morphogenesis namespace: biological_process def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] synonym: "guard cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010441 ! guard cell development [Term] id: GO:0010443 name: meristemoid mother cell division namespace: biological_process def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] synonym: "meristemoid division" RELATED [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010444 name: guard mother cell differentiation namespace: biological_process def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010445 name: nuclear dicing body namespace: cellular_component def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] synonym: "D body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0010446 name: response to alkaline pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH] synonym: "response to alkalinity" BROAD [] synonym: "response to basic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010447 name: response to acidic pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH] comment: This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'. synonym: "response to acidity" BROAD [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010448 name: vegetative meristem growth namespace: biological_process def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] is_a: GO:0035266 ! meristem growth is_a: GO:0080186 ! developmental vegetative growth relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0010449 name: root meristem growth namespace: biological_process def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048364 ! root development [Term] id: GO:0010450 name: inflorescence meristem growth namespace: biological_process def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0010451 name: floral meristem growth namespace: biological_process def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010452 name: histone H3-K36 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone." [GOC:pr, GOC:tb] synonym: "histone H3 K36 methylation" EXACT [GOC:tb] synonym: "histone H3K36me" EXACT [GOC:tb] synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045165 ! cell fate commitment relationship: regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045165 ! cell fate commitment relationship: negatively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045165 ! cell fate commitment relationship: positively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010456 name: cell proliferation in dorsal spinal cord namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] is_a: GO:0061351 ! neural precursor cell proliferation [Term] id: GO:0010457 name: centriole-centriole cohesion namespace: biological_process def: "The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0010458 name: exit from mitosis namespace: biological_process def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "exit from mitotic division" EXACT [] synonym: "mitotic exit" EXACT [] is_a: GO:0044772 ! mitotic cell cycle phase transition relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0010459 name: negative regulation of heart rate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0010460 name: positive regulation of heart rate namespace: biological_process def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0010461 name: light-activated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] is_a: GO:0005216 ! ion channel activity [Term] id: GO:0010462 name: regulation of light-activated voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity relationship: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010463 ! mesenchymal cell proliferation relationship: regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0010465 name: nerve growth factor receptor activity namespace: molecular_function def: "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] synonym: "beta-nerve growth factor receptor activity" EXACT [PR:000011194] synonym: "NGF receptor activity" EXACT [PR:000011194] is_a: GO:0005030 ! neurotrophin receptor activity relationship: has_part GO:0048406 ! nerve growth factor binding relationship: part_of GO:0038180 ! nerve growth factor signaling pathway [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008233 ! peptidase activity relationship: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010469 name: regulation of signaling receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] synonym: "regulation of receptor activity" BROAD [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038023 ! signaling receptor activity relationship: regulates GO:0038023 ! signaling receptor activity [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007369 ! gastrulation relationship: regulates GO:0007369 ! gastrulation [Term] id: GO:0010471 name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate." [MetaCyc:RXN4FS-12, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12] xref: MetaCyc:RXN4FS-12 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0010472 name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose." [MetaCyc:RXN4FS-13, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13] xref: MetaCyc:RXN4FS-13 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010473 name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010474 name: glucose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] synonym: "GDP:glucose-1-phosphate guanyltransferase activity" EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010475 name: galactose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] synonym: "GDP:galactose-1-phosphate guanyltransferase activity" EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010476 name: gibberellin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] synonym: "gibberellin-mediated signalling" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071370 ! cellular response to gibberellin stimulus [Term] id: GO:0010477 name: response to sulfur dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010478 name: chlororespiration namespace: biological_process def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0010479 name: stele development namespace: biological_process def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048364 ! root development [Term] id: GO:0010480 name: microsporocyte differentiation namespace: biological_process def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248, PMID:16751349] synonym: "pollen mother cell differentiation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048533 ! sporocyte differentiation relationship: part_of GO:0048653 ! anther development [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010481 ! epidermal cell division relationship: regulates GO:0010481 ! epidermal cell division [Term] id: GO:0010483 name: pollen tube reception namespace: biological_process def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0051703 ! intraspecies interaction between organisms relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010484 name: H3 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity relationship: part_of GO:0043966 ! histone H3 acetylation [Term] id: GO:0010485 name: H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity relationship: part_of GO:0043967 ! histone H4 acetylation [Term] id: GO:0010486 name: manganese:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] synonym: "manganese:hydrogen antiporter activity" EXACT [] is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0010487 name: thermospermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575] xref: EC:2.5.1.79 xref: MetaCyc:RXN-11190 xref: RHEA:30515 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0010488 name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0010489 name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0010490 name: UDP-4-keto-rhamnose-4-keto-reductase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0010491 name: UTP:arabinose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0010492 name: maintenance of shoot apical meristem identity namespace: biological_process def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010493 name: Lewis a epitope biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] synonym: "LE A biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0010494 name: cytoplasmic stress granule namespace: cellular_component def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] synonym: "cytoplasmic mRNP granule" EXACT [] synonym: "stress granule" EXACT [] xref: Wikipedia:Stress_granule is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule [Term] id: GO:0010495 name: long-distance posttranscriptional gene silencing namespace: biological_process def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0010496 name: intercellular transport namespace: biological_process alt_id: GO:1902585 def: "The movement of substances between cells." [GOC:dhl] synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intercellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process created_by: jl creation_date: 2013-12-19T13:24:56Z [Term] id: GO:0010497 name: plasmodesmata-mediated intercellular transport namespace: biological_process alt_id: GO:1902587 def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] synonym: "plasmodesma-mediated intercellular transport" EXACT [] synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] synonym: "single organism plasmodesmata-mediated intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism plasmodesmata-mediated intercellular transport" RELATED [] is_a: GO:0010496 ! intercellular transport created_by: jl creation_date: 2013-12-19T13:37:36Z [Term] id: GO:0010498 name: proteasomal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] synonym: "proteasome-mediated protein catabolic process" EXACT [] synonym: "proteasome-mediated protein catabolism" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0010499 name: proteasomal ubiquitin-independent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0010500 name: transmitting tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] is_a: GO:0048467 ! gynoecium development [Term] id: GO:0010501 name: RNA secondary structure unwinding namespace: biological_process def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] synonym: "RNA duplex unwinding" EXACT [GOC:ecd] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0010503 name: obsolete negative regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010504 name: obsolete regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010505 name: obsolete positive regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006914 ! autophagy relationship: regulates GO:0006914 ! autophagy [Term] id: GO:0010507 name: negative regulation of autophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031330 ! negative regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006914 ! autophagy relationship: negatively_regulates GO:0006914 ! autophagy [Term] id: GO:0010508 name: positive regulation of autophagy namespace: biological_process def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031331 ! positive regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006914 ! autophagy relationship: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0010509 name: polyamine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010510 name: regulation of acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0010511 name: regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010512 name: negative regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010513 name: positive regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010514 name: induction of conjugation with cellular fusion namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0010515 name: negative regulation of induction of conjugation with cellular fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0010516 name: negative regulation of cellular response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation [Term] id: GO:0010517 name: regulation of phospholipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060191 ! regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004620 ! phospholipase activity relationship: regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010518 name: positive regulation of phospholipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060193 ! positive regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004620 ! phospholipase activity relationship: positively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010519 name: negative regulation of phospholipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060192 ! negative regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004620 ! phospholipase activity relationship: negatively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010520 name: regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0060631 ! regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007131 ! reciprocal meiotic recombination relationship: regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010521 name: telomerase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0003720 ! telomerase activity relationship: part_of GO:0051974 ! negative regulation of telomerase activity [Term] id: GO:0010522 name: regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051924 ! regulation of calcium ion transport is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060402 ! calcium ion transport into cytosol relationship: regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010523 name: negative regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051926 ! negative regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060402 ! calcium ion transport into cytosol relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010524 name: positive regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051928 ! positive regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060402 ! calcium ion transport into cytosol relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010525 name: regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032197 ! transposition, RNA-mediated relationship: regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010526 name: negative regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010529 ! negative regulation of transposition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032197 ! transposition, RNA-mediated relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010527 name: positive regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010530 ! positive regulation of transposition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032197 ! transposition, RNA-mediated relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010528 name: regulation of transposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032196 ! transposition relationship: regulates GO:0032196 ! transposition [Term] id: GO:0010529 name: negative regulation of transposition namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032196 ! transposition relationship: negatively_regulates GO:0032196 ! transposition [Term] id: GO:0010530 name: positive regulation of transposition namespace: biological_process def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032196 ! transposition relationship: positively_regulates GO:0032196 ! transposition [Term] id: GO:0010533 name: regulation of activation of Janus kinase activity namespace: biological_process alt_id: GO:0010532 alt_id: GO:0010534 def: "Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582] synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "regulation of activation of JAK1 kinase activity" NARROW [] synonym: "regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of activation of JAK2 kinase activity" NARROW [] synonym: "regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042976 ! activation of Janus kinase activity relationship: regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010536 name: positive regulation of activation of Janus kinase activity namespace: biological_process alt_id: GO:0010535 alt_id: GO:0010537 def: "Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of activation of JAK1 kinase activity" NARROW [] synonym: "positive regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of activation of JAK2 kinase activity" NARROW [] synonym: "positive regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] is_a: GO:0010533 ! regulation of activation of Janus kinase activity is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042976 ! activation of Janus kinase activity relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010538 name: obsolete Hsp27 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. synonym: "Hsp27 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010539 name: obsolete Hsp27 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. synonym: "Hsp27 protein inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010540 name: basipetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010541 name: acropetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010542 name: nitrate efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0010543 name: regulation of platelet activation namespace: biological_process def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030168 ! platelet activation relationship: regulates GO:0030168 ! platelet activation [Term] id: GO:0010544 name: negative regulation of platelet activation namespace: biological_process def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030168 ! platelet activation relationship: negatively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010545 name: obsolete Hsp90 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. synonym: "Hsp90 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010546 name: obsolete Hsp90 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. synonym: "Hsp90 protein inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010547 name: thylakoid membrane disassembly namespace: biological_process def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733] synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010027 ! thylakoid membrane organization is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0010548 name: regulation of thylakoid membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010547 ! thylakoid membrane disassembly relationship: regulates GO:0010547 ! thylakoid membrane disassembly [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030397 ! membrane disassembly relationship: regulates GO:0030397 ! membrane disassembly [Term] id: GO:0010550 name: regulation of PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb] synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of LHCII degradation" EXACT [PMID:17416733] is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process [Term] id: GO:0010555 name: response to mannitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [PMID:17999646] synonym: "response to mannitol stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:1903018 ! regulation of glycoprotein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009101 ! glycoprotein biosynthetic process relationship: regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009101 ! glycoprotein biosynthetic process relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022402 ! cell cycle process relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010565 name: regulation of cellular ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042180 ! cellular ketone metabolic process relationship: regulates GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042181 ! ketone biosynthetic process relationship: regulates GO:0042181 ! ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042182 ! ketone catabolic process relationship: regulates GO:0042182 ! ketone catabolic process [Term] id: GO:0010568 name: regulation of budding cell apical bud growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0040008 ! regulation of growth is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007118 ! budding cell apical bud growth relationship: regulates GO:0007118 ! budding cell apical bud growth [Term] id: GO:0010569 name: regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000724 ! double-strand break repair via homologous recombination relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0010570 name: regulation of filamentous growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0040008 ! regulation of growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030447 ! filamentous growth relationship: regulates GO:0030447 ! filamentous growth [Term] id: GO:0010571 name: positive regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of DNA replication involved in S phase" EXACT [] synonym: "positive regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033260 ! nuclear DNA replication relationship: positively_regulates GO:0033260 ! nuclear DNA replication [Term] id: GO:0010572 name: positive regulation of platelet activation namespace: biological_process def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030168 ! platelet activation relationship: positively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010573 name: vascular endothelial growth factor production namespace: biological_process def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl] synonym: "VEGF production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0010574 name: regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010573 ! vascular endothelial growth factor production relationship: regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010575 name: positive regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0010574 ! regulation of vascular endothelial growth factor production relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010578 name: regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] synonym: "regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] synonym: "regulation of adenylate cyclase activity involved in G-protein signaling pathway" EXACT [GOC:signaling] synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah] is_a: GO:0045761 ! regulation of adenylate cyclase activity intersection_of: GO:0045761 ! regulation of adenylate cyclase activity intersection_of: part_of GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway relationship: part_of GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway [Term] id: GO:0010581 name: regulation of starch biosynthetic process namespace: biological_process def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019252 ! starch biosynthetic process relationship: regulates GO:0019252 ! starch biosynthetic process [Term] id: GO:0010582 name: floral meristem determinacy namespace: biological_process def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010022 ! meristem determinacy relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010583 name: response to cyclopentenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0010584 name: pollen exine formation namespace: biological_process def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl] is_a: GO:0010208 ! pollen wall assembly [Term] id: GO:0010585 name: glutamine secretion namespace: biological_process def: "The controlled release of glutamine by a cell." [PMID:15208395] is_a: GO:0006868 ! glutamine transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0010586 name: miRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] subset: goslim_drosophila synonym: "microRNA metabolic process" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0010587 name: miRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] synonym: "microRNA catabolic process" EXACT [] is_a: GO:0010586 ! miRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0010588 name: cotyledon vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439] is_a: GO:0010051 ! xylem and phloem pattern formation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0048826 ! cotyledon morphogenesis [Term] id: GO:0010589 name: leaf proximal/distal pattern formation namespace: biological_process def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054] is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0010590 name: regulation of septum digestion after cytokinesis namespace: biological_process alt_id: GO:1902467 alt_id: GO:2001041 def: "Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "regulation of cell separation after cytokinesis" RELATED [] synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "regulation of mitotic cytokinetic cell separation" EXACT [] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000920 ! septum digestion after cytokinesis relationship: regulates GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0010591 name: regulation of lamellipodium assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902743 ! regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030032 ! lamellipodium assembly relationship: regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010592 name: positive regulation of lamellipodium assembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902745 ! positive regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030032 ! lamellipodium assembly relationship: positively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010593 name: negative regulation of lamellipodium assembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902744 ! negative regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030032 ! lamellipodium assembly relationship: negatively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010594 name: regulation of endothelial cell migration namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043542 ! endothelial cell migration relationship: regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010595 name: positive regulation of endothelial cell migration namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0010634 ! positive regulation of epithelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043542 ! endothelial cell migration relationship: positively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010596 name: negative regulation of endothelial cell migration namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0010633 ! negative regulation of epithelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043542 ! endothelial cell migration relationship: negatively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010597 name: green leaf volatile biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881] is_a: GO:0019372 ! lipoxygenase pathway [Term] id: GO:0010598 name: NAD(P)H dehydrogenase complex (plastoquinone) namespace: cellular_component def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0010599 name: production of lsiRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861] synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0010600 name: regulation of auxin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0090354 ! regulation of auxin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009851 ! auxin biosynthetic process relationship: regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010601 name: positive regulation of auxin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0010600 ! regulation of auxin biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090355 ! positive regulation of auxin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009851 ! auxin biosynthetic process relationship: positively_regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010602 name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process [Term] id: GO:0010603 name: regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010606 name: positive regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010607 name: negative regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010608 name: posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010609 name: mRNA localization resulting in posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb] synonym: "mRNA localisation resulting in posttranscriptional regulation of gene expression" EXACT [] synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah] synonym: "posttranscriptional regulation of gene expression by mRNA localization" EXACT [] is_a: GO:0008298 ! intracellular mRNA localization is_a: GO:0010608 ! posttranscriptional regulation of gene expression [Term] id: GO:0010610 name: regulation of mRNA stability involved in response to stress namespace: biological_process def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb] is_a: GO:0043488 ! regulation of mRNA stability intersection_of: GO:0043488 ! regulation of mRNA stability intersection_of: part_of GO:0006950 ! response to stress relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003300 ! cardiac muscle hypertrophy relationship: regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014887 ! cardiac muscle adaptation relationship: regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003300 ! cardiac muscle hypertrophy relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014887 ! cardiac muscle adaptation relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014887 ! cardiac muscle adaptation relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010617 name: circadian regulation of calcium ion oscillation namespace: biological_process def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000] synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED [] synonym: "circadian regulation of Ca2+ oscillation" RELATED [] synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0010618 name: aerenchyma formation namespace: biological_process def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0010619 name: adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:signaling, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" RELATED [GOC:dph, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway" RELATED [GOC:signaling] synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" RELATED [GOC:mah] synonym: "adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway relationship: part_of GO:0010255 ! glucose mediated signaling pathway [Term] id: GO:0010620 name: negative regulation of transcription by transcription factor catabolism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:bf, GOC:dph, GOC:tb] is_a: GO:0036369 ! transcription factor catabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0036369 ! transcription factor catabolic process intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0010621 name: negative regulation of transcription by transcription factor localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb] synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010622 name: specification of ovule identity namespace: biological_process def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0048482 ! plant ovule morphogenesis [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: part_of GO:0048468 ! cell development relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010624 name: regulation of Schwann cell proliferation namespace: biological_process def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014010 ! Schwann cell proliferation relationship: regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010625 name: positive regulation of Schwann cell proliferation namespace: biological_process def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060252 ! positive regulation of glial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014010 ! Schwann cell proliferation relationship: positively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010626 name: negative regulation of Schwann cell proliferation namespace: biological_process def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060253 ! negative regulation of glial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014010 ! Schwann cell proliferation relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression [Term] id: GO:0010630 name: regulation of transcription, start site selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process [Term] id: GO:0010631 name: epithelial cell migration namespace: biological_process def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0090132 ! epithelium migration [Term] id: GO:0010632 name: regulation of epithelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010631 ! epithelial cell migration relationship: regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010633 name: negative regulation of epithelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010631 ! epithelial cell migration relationship: negatively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010634 name: positive regulation of epithelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010631 ! epithelial cell migration relationship: positively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010635 name: regulation of mitochondrial fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008053 ! mitochondrial fusion relationship: regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010636 name: positive regulation of mitochondrial fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008053 ! mitochondrial fusion relationship: positively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010637 name: negative regulation of mitochondrial fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008053 ! mitochondrial fusion relationship: negatively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006996 ! organelle organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006996 ! organelle organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010640 name: regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010641 name: positive regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010642 name: negative regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010643 name: cell communication by chemical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010644 name: cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010645 name: regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010643 ! cell communication by chemical coupling relationship: regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007154 ! cell communication relationship: regulates GO:0007154 ! cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007154 ! cell communication relationship: positively_regulates GO:0007154 ! cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007154 ! cell communication relationship: negatively_regulates GO:0007154 ! cell communication [Term] id: GO:0010649 name: regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010644 ! cell communication by electrical coupling relationship: regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010650 name: positive regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010644 ! cell communication by electrical coupling relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010651 name: negative regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010644 ! cell communication by electrical coupling relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010652 name: positive regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010647 ! positive regulation of cell communication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010643 ! cell communication by chemical coupling relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010653 name: negative regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010648 ! negative regulation of cell communication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010643 ! cell communication by chemical coupling relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010654 name: apical cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010656 name: negative regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010657 ! muscle cell apoptotic process relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010657 name: muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "muscle cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0010658 name: striated muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "striated muscle cell apoptosis" NARROW [] is_a: GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010659 name: cardiac muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010660 name: regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of muscle cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010657 ! muscle cell apoptotic process relationship: regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010661 name: positive regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010657 ! muscle cell apoptotic process relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010662 name: regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010658 ! striated muscle cell apoptotic process relationship: regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010658 ! striated muscle cell apoptotic process relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010659 ! cardiac muscle cell apoptotic process relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0010669 name: epithelial structure maintenance namespace: biological_process def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0010670 name: obsolete positive regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "positive regulation of oxygen and reactive oxygen species metabolic process" EXACT [] is_obsolete: true consider: GO:2000376 consider: GO:2000379 [Term] id: GO:0010671 name: obsolete negative regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "negative regulation of oxygen and reactive oxygen species metabolic process" EXACT [] is_obsolete: true consider: GO:2000375 consider: GO:2000378 [Term] id: GO:0010672 name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900401 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753] synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: mah creation_date: 2012-04-20T02:45:12Z [Term] id: GO:0010673 name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900476 def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dianna.fisk creation_date: 2012-05-01T08:40:11Z [Term] id: GO:0010674 name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900475 def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: dianna.fisk creation_date: 2012-05-01T08:39:58Z [Term] id: GO:0010675 name: regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044262 ! cellular carbohydrate metabolic process relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010676 name: positive regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010677 name: negative regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010678 name: negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated namespace: biological_process def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb] synonym: "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "negative regulation of cellular carbohydrate metabolic process by repression of transcription" EXACT [GOC:bf, GOC:vw] synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010679 name: cinnamic acid biosynthetic process involved in salicylic acid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: part_of GO:0009696 ! salicylic acid metabolic process relationship: part_of GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010680 name: cinnamic acid biosynthetic process involved in coumarin metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: part_of GO:0009804 ! coumarin metabolic process relationship: part_of GO:0009804 ! coumarin metabolic process [Term] id: GO:0010681 name: cinnamic acid biosynthetic process involved in stilbene metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: part_of GO:0009810 ! stilbene metabolic process relationship: part_of GO:0009810 ! stilbene metabolic process [Term] id: GO:0010682 name: cinnamic acid biosynthetic process involved in flavonoid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: GO:0009800 ! cinnamic acid biosynthetic process intersection_of: part_of GO:0009812 ! flavonoid metabolic process relationship: part_of GO:0009812 ! flavonoid metabolic process [Term] id: GO:0010683 name: tricyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0010684 name: tricyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0010685 name: tetracyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0010686 name: tetracyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0010688 name: negative regulation of ribosomal protein gene transcription by RNA polymerase II namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II [Term] id: GO:0010689 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0010690 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0010691 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II is_a: GO:0031669 ! cellular response to nutrient levels [Term] id: GO:0010692 name: regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004035 ! alkaline phosphatase activity relationship: regulates GO:0004035 ! alkaline phosphatase activity [Term] id: GO:0010693 name: negative regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010923 ! negative regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004035 ! alkaline phosphatase activity relationship: negatively_regulates GO:0004035 ! alkaline phosphatase activity [Term] id: GO:0010694 name: positive regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010922 ! positive regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004035 ! alkaline phosphatase activity relationship: positively_regulates GO:0004035 ! alkaline phosphatase activity [Term] id: GO:0010695 name: regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000073 ! initial mitotic spindle pole body separation relationship: regulates GO:0000073 ! initial mitotic spindle pole body separation [Term] id: GO:0010696 name: positive regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of mitotic spindle pole body separation is_a: GO:0110161 ! positive regulation of mitotic spindle formation (spindle phase one) intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000073 ! initial mitotic spindle pole body separation relationship: positively_regulates GO:0000073 ! initial mitotic spindle pole body separation [Term] id: GO:0010697 name: negative regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of mitotic spindle pole body separation is_a: GO:0110160 ! negative regulation of mitotic spindle formation (spindle phase one) intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000073 ! initial mitotic spindle pole body separation relationship: negatively_regulates GO:0000073 ! initial mitotic spindle pole body separation [Term] id: GO:0010698 name: acetyltransferase activator activity namespace: molecular_function def: "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240] synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0016407 ! acetyltransferase activity [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048243 ! norepinephrine secretion relationship: negatively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048243 ! norepinephrine secretion relationship: positively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010702 name: obsolete regulation of histolysis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0010703 name: obsolete negative regulation of histolysis namespace: biological_process def: "OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb] is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0010704 name: meiotic DNA double-strand break processing involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing intersection_of: GO:0000706 ! meiotic DNA double-strand break processing intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010705 name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing intersection_of: GO:0000706 ! meiotic DNA double-strand break processing intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010706 name: ganglioside biosynthetic process via lactosylceramide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] synonym: "biosynthesis of lactosylceramide precursor to ganglioside" RELATED [GOC:bf, GOC:dph, GOC:tb] synonym: "ganglioside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001574 ! ganglioside biosynthetic process [Term] id: GO:0010707 name: globoside biosynthetic process via lactosylceramide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] synonym: "biosynthesis of lactosylceramide precursor to globoside" RELATED [GOC:bf, GOC:dph, GOC:tb] synonym: "globoside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001576 ! globoside biosynthetic process [Term] id: GO:0010708 name: heteroduplex formation involved in gene conversion at mating-type locus namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0030491 ! heteroduplex formation intersection_of: GO:0030491 ! heteroduplex formation intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0010709 name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb] is_a: GO:0030491 ! heteroduplex formation intersection_of: GO:0030491 ! heteroduplex formation intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030574 ! collagen catabolic process relationship: regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030574 ! collagen catabolic process relationship: negatively_regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032963 ! collagen metabolic process relationship: regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032963 ! collagen metabolic process relationship: negatively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032963 ! collagen metabolic process relationship: positively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022617 ! extracellular matrix disassembly relationship: regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022617 ! extracellular matrix disassembly relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001837 ! epithelial to mesenchymal transition relationship: regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001837 ! epithelial to mesenchymal transition relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048468 ! cell development relationship: positively_regulates GO:0048468 ! cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048468 ! cell development relationship: negatively_regulates GO:0048468 ! cell development [Term] id: GO:0010722 name: regulation of ferrochelatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb] is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004325 ! ferrochelatase activity relationship: regulates GO:0004325 ! ferrochelatase activity [Term] id: GO:0010723 name: positive regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb] is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [Term] id: GO:0010724 name: regulation of definitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060318 ! definitive erythrocyte differentiation relationship: regulates GO:0060318 ! definitive erythrocyte differentiation [Term] id: GO:0010725 name: regulation of primitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060319 ! primitive erythrocyte differentiation relationship: regulates GO:0060319 ! primitive erythrocyte differentiation [Term] id: GO:0010726 name: positive regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010727 name: negative regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010728 name: regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050665 ! hydrogen peroxide biosynthetic process relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010729 name: positive regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010730 name: negative regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010731 name: protein glutathionylation namespace: biological_process def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0010732 name: regulation of protein glutathionylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010731 ! protein glutathionylation relationship: regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010733 name: positive regulation of protein glutathionylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031401 ! positive regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010731 ! protein glutathionylation relationship: positively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010734 name: negative regulation of protein glutathionylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031400 ! negative regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010731 ! protein glutathionylation relationship: negatively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010735 name: positive regulation of transcription via serum response element binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II [Term] id: GO:0010736 name: serum response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding [Term] id: GO:0010737 name: protein kinase A signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "protein kinase A signal transduction" EXACT [GOC:signaling] synonym: "protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0010738 name: regulation of protein kinase A signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "regulation of protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010737 ! protein kinase A signaling relationship: regulates GO:0010737 ! protein kinase A signaling [Term] id: GO:0010739 name: positive regulation of protein kinase A signaling namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:0010738 ! regulation of protein kinase A signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010737 ! protein kinase A signaling relationship: positively_regulates GO:0010737 ! protein kinase A signaling [Term] id: GO:0010742 name: macrophage derived foam cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation [Term] id: GO:0010743 name: regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010742 ! macrophage derived foam cell differentiation relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010744 name: positive regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010745 name: negative regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010746 name: regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015911 ! long-chain fatty acid import across plasma membrane relationship: regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010747 name: positive regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane is_a: GO:0140214 ! positive regulation of long-chain fatty acid import into cell is_a: GO:1903961 ! positive regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane relationship: positively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010748 name: negative regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane is_a: GO:0140213 ! negative regulation of long-chain fatty acid import into cell is_a: GO:1903960 ! negative regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane relationship: negatively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010749 name: regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007263 ! nitric oxide mediated signal transduction relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010750 name: positive regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010751 name: negative regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010752 name: regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019934 ! cGMP-mediated signaling relationship: regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010753 name: positive regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019934 ! cGMP-mediated signaling relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010754 name: negative regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019934 ! cGMP-mediated signaling relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010755 name: regulation of plasminogen activation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0070613 ! regulation of protein processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031639 ! plasminogen activation relationship: regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010756 name: positive regulation of plasminogen activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010954 ! positive regulation of protein processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031639 ! plasminogen activation relationship: positively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010757 name: negative regulation of plasminogen activation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010955 ! negative regulation of protein processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031639 ! plasminogen activation relationship: negatively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010758 name: regulation of macrophage chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048246 ! macrophage chemotaxis relationship: regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010759 name: positive regulation of macrophage chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048246 ! macrophage chemotaxis relationship: positively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010760 name: negative regulation of macrophage chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048246 ! macrophage chemotaxis relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010761 name: fibroblast migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] synonym: "fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0010762 name: regulation of fibroblast migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010761 ! fibroblast migration relationship: regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010763 name: positive regulation of fibroblast migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010761 ! fibroblast migration relationship: positively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010764 name: negative regulation of fibroblast migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010761 ! fibroblast migration relationship: negatively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010765 name: positive regulation of sodium ion transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006814 ! sodium ion transport relationship: positively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010766 name: negative regulation of sodium ion transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006814 ! sodium ion transport relationship: negatively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010767 name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0034644 ! cellular response to UV is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0010768 name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [Term] id: GO:0010769 name: regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010770 name: positive regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010771 name: negative regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010772 name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly intersection_of: GO:0000707 ! meiotic DNA recombinase assembly intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010773 name: meiotic DNA recombinase assembly involved in meiotic gene conversion namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly intersection_of: GO:0000707 ! meiotic DNA recombinase assembly intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010774 name: meiotic strand invasion involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion intersection_of: GO:0000708 ! meiotic strand invasion intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010775 name: meiotic strand invasion involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion intersection_of: GO:0000708 ! meiotic strand invasion intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010776 name: meiotic mismatch repair involved in meiotic gene conversion namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair intersection_of: GO:0000710 ! meiotic mismatch repair intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010777 name: meiotic mismatch repair involved in reciprocal meiotic recombination namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair intersection_of: GO:0000710 ! meiotic mismatch repair intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010778 name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis intersection_of: GO:0000711 ! meiotic DNA repair synthesis intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010779 name: meiotic DNA repair synthesis involved in meiotic gene conversion namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis intersection_of: GO:0000711 ! meiotic DNA repair synthesis intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010780 name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation intersection_of: GO:0042138 ! meiotic DNA double-strand break formation intersection_of: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010781 name: meiotic DNA double-strand break formation involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation intersection_of: GO:0042138 ! meiotic DNA double-strand break formation intersection_of: part_of GO:0006311 ! meiotic gene conversion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010782 name: proboscis morphogenesis, labial disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007454 ! labial disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010783 name: proboscis morphogenesis, eye-antennal disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010784 name: proboscis morphogenesis, clypeo-labral disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010785 name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome [Term] id: GO:0010786 name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome [Term] id: GO:0010787 name: COPI coating of Golgi vesicle, inter-Golgi cisterna namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna [Term] id: GO:0010788 name: COPI coating of Golgi vesicle, cis-Golgi to rough ER namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough endoplasmic reticulum [Term] id: GO:0010789 name: meiotic sister chromatid cohesion involved in meiosis I namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion intersection_of: GO:0051177 ! meiotic sister chromatid cohesion intersection_of: part_of GO:0007127 ! meiosis I relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0010790 name: meiotic sister chromatid cohesion involved in meiosis II namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0010791 name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing intersection_of: GO:0000729 ! DNA double-strand break processing intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010792 name: DNA double-strand break processing involved in repair via single-strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing intersection_of: GO:0000729 ! DNA double-strand break processing intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0010793 name: regulation of mRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0046831 ! regulation of RNA export from nucleus is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006406 ! mRNA export from nucleus relationship: regulates GO:0006406 ! mRNA export from nucleus [Term] id: GO:0010794 name: regulation of dolichol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019408 ! dolichol biosynthetic process relationship: regulates GO:0019408 ! dolichol biosynthetic process [Term] id: GO:0010795 name: regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006744 ! ubiquinone biosynthetic process relationship: regulates GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0010796 name: regulation of multivesicular body size namespace: biological_process def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0051036 ! regulation of endosome size [Term] id: GO:0010797 name: regulation of multivesicular body size involved in endosome transport namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size intersection_of: GO:0010796 ! regulation of multivesicular body size intersection_of: part_of GO:0016197 ! endosomal transport relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway [Term] id: GO:0010798 name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size intersection_of: GO:0010796 ! regulation of multivesicular body size intersection_of: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0010799 name: regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018107 ! peptidyl-threonine phosphorylation relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010800 name: positive regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010801 name: negative regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010803 name: regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010804 name: negative regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010807 name: regulation of synaptic vesicle priming namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] subset: goslim_synapse is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016082 ! synaptic vesicle priming relationship: regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010808 name: positive regulation of synaptic vesicle priming namespace: biological_process def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016082 ! synaptic vesicle priming relationship: positively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010809 name: negative regulation of synaptic vesicle priming namespace: biological_process def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016082 ! synaptic vesicle priming relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010810 name: regulation of cell-substrate adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031589 ! cell-substrate adhesion relationship: regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010811 name: positive regulation of cell-substrate adhesion namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0010810 ! regulation of cell-substrate adhesion is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031589 ! cell-substrate adhesion relationship: positively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010812 name: negative regulation of cell-substrate adhesion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0010810 ! regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031589 ! cell-substrate adhesion relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010813 name: neuropeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010814 name: substance P catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl] is_a: GO:0010813 ! neuropeptide catabolic process [Term] id: GO:0010815 name: bradykinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl] is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010816 name: calcitonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010818 name: T cell chemotaxis namespace: biological_process def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] synonym: "T-cell chemotaxis" EXACT [CL:0000084] is_a: GO:0048247 ! lymphocyte chemotaxis is_a: GO:0072678 ! T cell migration [Term] id: GO:0010819 name: regulation of T cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010818 ! T cell chemotaxis relationship: regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010820 name: positive regulation of T cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010819 ! regulation of T cell chemotaxis is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000406 ! positive regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010818 ! T cell chemotaxis relationship: positively_regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007005 ! mitochondrion organization relationship: regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010822 name: positive regulation of mitochondrion organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007005 ! mitochondrion organization relationship: positively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010823 name: negative regulation of mitochondrion organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007005 ! mitochondrion organization relationship: negatively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010824 name: regulation of centrosome duplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0046605 ! regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051298 ! centrosome duplication relationship: regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010825 name: positive regulation of centrosome duplication namespace: biological_process def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010824 ! regulation of centrosome duplication is_a: GO:0046607 ! positive regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051298 ! centrosome duplication relationship: positively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010826 name: negative regulation of centrosome duplication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010824 ! regulation of centrosome duplication is_a: GO:0046606 ! negative regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051298 ! centrosome duplication relationship: negatively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010827 name: regulation of glucose transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] synonym: "regulation of glucose transport" RELATED [] is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904659 ! glucose transmembrane transport relationship: regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010828 name: positive regulation of glucose transmembrane transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of glucose transmembrane transport is_a: GO:0034764 ! positive regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904659 ! glucose transmembrane transport relationship: positively_regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010829 name: negative regulation of glucose transmembrane transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of glucose transmembrane transport is_a: GO:0034763 ! negative regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904659 ! glucose transmembrane transport relationship: negatively_regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014902 ! myotube differentiation relationship: regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014902 ! myotube differentiation relationship: positively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014902 ! myotube differentiation relationship: negatively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010833 name: telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0010834 name: obsolete telomere maintenance via telomere shortening namespace: biological_process def: "OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb] comment: This term was made obsolete because it represents a phenotype. synonym: "telomere maintenance via telomere shortening" EXACT [] is_obsolete: true consider: GO:1903824 [Term] id: GO:0010835 name: regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb] synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006471 ! protein ADP-ribosylation relationship: regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010836 name: negative regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0010835 ! regulation of protein ADP-ribosylation is_a: GO:0031400 ! negative regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006471 ! protein ADP-ribosylation relationship: negatively_regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010837 name: regulation of keratinocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043616 ! keratinocyte proliferation relationship: regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010838 name: positive regulation of keratinocyte proliferation namespace: biological_process def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043616 ! keratinocyte proliferation relationship: positively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010839 name: negative regulation of keratinocyte proliferation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043616 ! keratinocyte proliferation relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010840 name: regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010841 name: positive regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0010843 name: obsolete promoter binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167] comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae. synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb] synonym: "promoter binding" EXACT [] is_obsolete: true consider: GO:0001047 consider: GO:0044212 [Term] id: GO:0010844 name: recombination hotspot binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region in a genome which promotes recombination." [GOC:dph, GOC:tb] synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb] is_a: GO:0003677 ! DNA binding [Term] id: GO:0010845 name: positive regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0060903 ! positive regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007131 ! reciprocal meiotic recombination relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010846 name: activation of reciprocal meiotic recombination namespace: biological_process def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination [Term] id: GO:0010847 name: regulation of chromatin assembly namespace: biological_process def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031497 ! chromatin assembly relationship: regulates GO:0031497 ! chromatin assembly [Term] id: GO:0010848 name: regulation of chromatin disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031498 ! chromatin disassembly relationship: regulates GO:0031498 ! chromatin disassembly [Term] id: GO:0010849 name: regulation of proton-transporting ATPase activity, rotational mechanism namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb] synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046961 ! proton-transporting ATPase activity, rotational mechanism relationship: regulates GO:0046961 ! proton-transporting ATPase activity, rotational mechanism [Term] id: GO:0010850 name: regulation of blood pressure by chemoreceptor signaling pathway namespace: biological_process def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb] synonym: "regulation of blood pressure by chemoreceptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0010851 name: cyclase regulator activity namespace: molecular_function def: "Modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0031279 ! regulation of cyclase activity [Term] id: GO:0010852 name: cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity intersection_of: GO:0030234 ! enzyme regulator activity intersection_of: negatively_regulates GO:0009975 ! cyclase activity relationship: negatively_regulates GO:0009975 ! cyclase activity [Term] id: GO:0010853 name: cyclase activator activity namespace: molecular_function def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010854 name: adenylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010855 name: adenylate cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010854 ! adenylate cyclase regulator activity [Term] id: GO:0010856 name: adenylate cyclase activator activity namespace: molecular_function def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0010857 name: calcium-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium." [GOC:dph, GOC:tb] xref: Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308" xref: Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0010858 name: calcium-dependent protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0010859 name: calcium-dependent cysteine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity [Term] id: GO:0010860 name: obsolete proteasome regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "proteasome regulator activity" EXACT [] is_obsolete: true consider: GO:0061135 consider: GO:0061136 [Term] id: GO:0010862 name: positive regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0010863 name: positive regulation of phospholipase C activity namespace: biological_process def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:1900274 ! regulation of phospholipase C activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004629 ! phospholipase C activity relationship: positively_regulates GO:0004629 ! phospholipase C activity [Term] id: GO:0010864 name: positive regulation of protein histidine kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0032110 ! regulation of protein histidine kinase activity is_a: GO:0045860 ! positive regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004673 ! protein histidine kinase activity relationship: positively_regulates GO:0004673 ! protein histidine kinase activity [Term] id: GO:0010865 name: stipule development namespace: biological_process def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0010866 name: regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:0090207 ! regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019432 ! triglyceride biosynthetic process relationship: regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010867 name: positive regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019432 ! triglyceride biosynthetic process relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010868 name: negative regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019432 ! triglyceride biosynthetic process relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010869 name: regulation of receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032800 ! receptor biosynthetic process relationship: regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010870 name: positive regulation of receptor biosynthetic process namespace: biological_process def: "Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032800 ! receptor biosynthetic process relationship: positively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010871 name: negative regulation of receptor biosynthetic process namespace: biological_process def: "Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032800 ! receptor biosynthetic process relationship: negatively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010872 name: regulation of cholesterol esterification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034435 ! cholesterol esterification relationship: regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010873 name: positive regulation of cholesterol esterification namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010872 ! regulation of cholesterol esterification is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034435 ! cholesterol esterification relationship: positively_regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010874 name: regulation of cholesterol efflux namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033344 ! cholesterol efflux relationship: regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010875 name: positive regulation of cholesterol efflux namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010874 ! regulation of cholesterol efflux is_a: GO:0032376 ! positive regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033344 ! cholesterol efflux relationship: positively_regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0010877 name: lipid transport involved in lipid storage namespace: biological_process def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0006869 ! lipid transport intersection_of: GO:0006869 ! lipid transport intersection_of: part_of GO:0019915 ! lipid storage relationship: part_of GO:0019915 ! lipid storage [Term] id: GO:0010878 name: cholesterol storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb] is_a: GO:0019915 ! lipid storage [Term] id: GO:0010879 name: cholesterol transport involved in cholesterol storage namespace: biological_process def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb] is_a: GO:0010877 ! lipid transport involved in lipid storage is_a: GO:0030301 ! cholesterol transport intersection_of: GO:0030301 ! cholesterol transport intersection_of: part_of GO:0010878 ! cholesterol storage relationship: part_of GO:0010878 ! cholesterol storage [Term] id: GO:0010880 name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [Term] id: GO:0010881 name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling [Term] id: GO:0010882 name: regulation of cardiac muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0019722 ! calcium-mediated signaling intersection_of: regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0010883 name: regulation of lipid storage namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019915 ! lipid storage relationship: regulates GO:0019915 ! lipid storage [Term] id: GO:0010884 name: positive regulation of lipid storage namespace: biological_process def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019915 ! lipid storage relationship: positively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010885 name: regulation of cholesterol storage namespace: biological_process def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010878 ! cholesterol storage relationship: regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010886 name: positive regulation of cholesterol storage namespace: biological_process def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010885 ! regulation of cholesterol storage intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010878 ! cholesterol storage relationship: positively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010887 name: negative regulation of cholesterol storage namespace: biological_process def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010885 ! regulation of cholesterol storage is_a: GO:0010888 ! negative regulation of lipid storage intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010878 ! cholesterol storage relationship: negatively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010888 name: negative regulation of lipid storage namespace: biological_process def: "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019915 ! lipid storage relationship: negatively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010889 name: regulation of sequestering of triglyceride namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030730 ! sequestering of triglyceride relationship: regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010890 name: positive regulation of sequestering of triglyceride namespace: biological_process def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030730 ! sequestering of triglyceride relationship: positively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010891 name: negative regulation of sequestering of triglyceride namespace: biological_process def: "Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010888 ! negative regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030730 ! sequestering of triglyceride relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010892 name: positive regulation of mitochondrial translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070131 ! positive regulation of mitochondrial translation [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006694 ! steroid biosynthetic process relationship: positively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006694 ! steroid biosynthetic process relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010895 name: negative regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032443 ! regulation of ergosterol biosynthetic process is_a: GO:0106119 ! negative regulation of sterol biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006696 ! ergosterol biosynthetic process relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0010896 name: regulation of triglyceride catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019433 ! triglyceride catabolic process relationship: regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010897 name: negative regulation of triglyceride catabolic process namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019433 ! triglyceride catabolic process relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010898 name: positive regulation of triglyceride catabolic process namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019433 ! triglyceride catabolic process relationship: positively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010899 name: regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034638 ! phosphatidylcholine catabolic process relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010900 name: negative regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010901 name: regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010902 name: positive regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010903 name: negative regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010904 name: regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006258 ! UDP-glucose catabolic process relationship: regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010905 name: negative regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010904 ! regulation of UDP-glucose catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006258 ! UDP-glucose catabolic process relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010906 name: regulation of glucose metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006006 ! glucose metabolic process relationship: regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010907 name: positive regulation of glucose metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006006 ! glucose metabolic process relationship: positively_regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010908 name: regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010909 name: positive regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:1902730 ! positive regulation of proteoglycan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010910 name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb] is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:0010912 ! positive regulation of isomerase activity [Term] id: GO:0010911 name: regulation of isomerase activity namespace: biological_process def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016853 ! isomerase activity relationship: regulates GO:0016853 ! isomerase activity [Term] id: GO:0010912 name: positive regulation of isomerase activity namespace: biological_process def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0010911 ! regulation of isomerase activity is_a: GO:0043085 ! positive regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016853 ! isomerase activity relationship: positively_regulates GO:0016853 ! isomerase activity [Term] id: GO:0010913 name: regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045461 ! sterigmatocystin biosynthetic process relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010914 name: positive regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010915 name: regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034447 ! very-low-density lipoprotein particle clearance relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010916 name: negative regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010917 name: negative regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045837 ! negative regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010918 name: positive regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045838 ! positive regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010919 name: regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032958 ! inositol phosphate biosynthetic process relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010920 name: negative regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010921 name: regulation of phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016791 ! phosphatase activity relationship: regulates GO:0016791 ! phosphatase activity [Term] id: GO:0010922 name: positive regulation of phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0035306 ! positive regulation of dephosphorylation is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016791 ! phosphatase activity relationship: positively_regulates GO:0016791 ! phosphatase activity [Term] id: GO:0010923 name: negative regulation of phosphatase activity namespace: biological_process def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0035305 ! negative regulation of dephosphorylation is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016791 ! phosphatase activity relationship: negatively_regulates GO:0016791 ! phosphatase activity [Term] id: GO:0010924 name: regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity relationship: regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity [Term] id: GO:0010925 name: positive regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity relationship: positively_regulates GO:0004445 ! inositol-polyphosphate 5-phosphatase activity [Term] id: GO:0010926 name: obsolete anatomical structure formation namespace: biological_process def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb] comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful. synonym: "anatomical structure formation" EXACT [] is_obsolete: true consider: GO:0022607 consider: GO:0048646 [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010928 name: regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009734 ! auxin-activated signaling pathway relationship: regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010929 name: positive regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009734 ! auxin-activated signaling pathway relationship: positively_regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010930 name: negative regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009734 ! auxin-activated signaling pathway relationship: negatively_regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010931 name: macrophage tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0010932 name: regulation of macrophage tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010931 ! macrophage tolerance induction relationship: regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010933 name: positive regulation of macrophage tolerance induction namespace: biological_process def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0010932 ! regulation of macrophage tolerance induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010931 ! macrophage tolerance induction relationship: positively_regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010934 name: macrophage cytokine production namespace: biological_process def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0010935 name: regulation of macrophage cytokine production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010934 ! macrophage cytokine production relationship: regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010936 name: negative regulation of macrophage cytokine production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0010935 ! regulation of macrophage cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010934 ! macrophage cytokine production relationship: negatively_regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010938 ! cytoplasmic microtubule depolymerization relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: occurs_in GO:0005737 ! cytoplasm relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0010939 name: regulation of necrotic cell death namespace: biological_process def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010941 ! regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070265 ! necrotic cell death relationship: regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010940 name: positive regulation of necrotic cell death namespace: biological_process def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0010942 ! positive regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070265 ! necrotic cell death relationship: positively_regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010941 name: regulation of cell death namespace: biological_process def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008219 ! cell death relationship: regulates GO:0008219 ! cell death [Term] id: GO:0010942 name: positive regulation of cell death namespace: biological_process def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008219 ! cell death relationship: positively_regulates GO:0008219 ! cell death [Term] id: GO:0010943 name: NADPH pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0010944 name: negative regulation of transcription by competitive promoter binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010945 name: CoA pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb] is_a: GO:0016462 ! pyrophosphatase activity created_by: tanyaberardini creation_date: 2009-04-22T02:06:40Z [Term] id: GO:0010946 name: regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000709 ! meiotic joint molecule formation relationship: regulates GO:0000709 ! meiotic joint molecule formation created_by: tanyaberardini creation_date: 2009-04-27T09:46:23Z [Term] id: GO:0010947 name: negative regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010946 ! regulation of meiotic joint molecule formation is_a: GO:0045128 ! negative regulation of reciprocal meiotic recombination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000709 ! meiotic joint molecule formation relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation created_by: tanyaberardini creation_date: 2009-04-27T09:48:53Z [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022402 ! cell cycle process relationship: negatively_regulates GO:0022402 ! cell cycle process created_by: tanyaberardini creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010949 name: negative regulation of intestinal phytosterol absorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:1904730 ! negative regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060752 ! intestinal phytosterol absorption relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption created_by: tanyaberardini creation_date: 2009-04-27T11:02:06Z [Term] id: GO:0010950 name: positive regulation of endopeptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004175 ! endopeptidase activity relationship: positively_regulates GO:0004175 ! endopeptidase activity created_by: tanyaberardini creation_date: 2009-04-27T11:45:39Z [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] subset: goslim_chembl is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004175 ! endopeptidase activity relationship: negatively_regulates GO:0004175 ! endopeptidase activity created_by: tanyaberardini creation_date: 2009-04-27T11:47:01Z [Term] id: GO:0010952 name: positive regulation of peptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008233 ! peptidase activity relationship: positively_regulates GO:0008233 ! peptidase activity created_by: tanyaberardini creation_date: 2009-04-27T11:54:32Z [Term] id: GO:0010954 name: positive regulation of protein processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903319 ! positive regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016485 ! protein processing relationship: positively_regulates GO:0016485 ! protein processing created_by: tanyaberardini creation_date: 2009-04-27T12:09:13Z [Term] id: GO:0010955 name: negative regulation of protein processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903318 ! negative regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016485 ! protein processing relationship: negatively_regulates GO:0016485 ! protein processing created_by: tanyaberardini creation_date: 2009-04-27T12:10:19Z [Term] id: GO:0010956 name: negative regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity relationship: negatively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity created_by: tanyaberardini creation_date: 2009-05-06T11:21:34Z [Term] id: GO:0010957 name: negative regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042368 ! vitamin D biosynthetic process relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process created_by: tanyaberardini creation_date: 2009-05-06T11:25:12Z [Term] id: GO:0010958 name: regulation of amino acid import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] synonym: "regulation of amino acid import" BROAD [] is_a: GO:1903789 ! regulation of amino acid transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0089718 ! amino acid import across plasma membrane relationship: regulates GO:0089718 ! amino acid import across plasma membrane created_by: tanyaberardini creation_date: 2009-05-06T11:33:12Z [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030001 ! metal ion transport relationship: regulates GO:0030001 ! metal ion transport created_by: tanyaberardini creation_date: 2009-05-06T11:40:55Z [Term] id: GO:0010960 name: magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: tanyaberardini creation_date: 2009-05-06T11:47:17Z [Term] id: GO:0010961 name: cellular magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell." [GOC:dph, GOC:tb] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0010960 ! magnesium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis created_by: tanyaberardini creation_date: 2009-05-06T11:48:45Z [Term] id: GO:0010962 name: regulation of glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009250 ! glucan biosynthetic process relationship: regulates GO:0009250 ! glucan biosynthetic process created_by: tanyaberardini creation_date: 2009-05-11T12:17:53Z [Term] id: GO:0010963 name: regulation of L-arginine import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902023 ! L-arginine transport relationship: regulates GO:1902023 ! L-arginine transport created_by: tanyaberardini creation_date: 2009-05-20T11:20:18Z [Term] id: GO:0010964 name: regulation of chromatin silencing by small RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031048 ! chromatin silencing by small RNA relationship: regulates GO:0031048 ! chromatin silencing by small RNA created_by: tanyaberardini creation_date: 2009-05-20T11:25:42Z [Term] id: GO:0010965 name: regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:1905818 ! regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051306 ! mitotic sister chromatid separation relationship: regulates GO:0051306 ! mitotic sister chromatid separation created_by: tanyaberardini creation_date: 2009-05-20T11:39:07Z [Term] id: GO:0010966 name: regulation of phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006817 ! phosphate ion transport relationship: regulates GO:0006817 ! phosphate ion transport created_by: tanyaberardini creation_date: 2009-05-20T11:42:50Z [Term] id: GO:0010967 name: regulation of polyamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006596 ! polyamine biosynthetic process relationship: regulates GO:0006596 ! polyamine biosynthetic process created_by: tanyaberardini creation_date: 2009-05-20T11:45:37Z [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0031113 ! regulation of microtubule polymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007020 ! microtubule nucleation relationship: regulates GO:0007020 ! microtubule nucleation created_by: tanyaberardini creation_date: 2009-05-20T11:51:21Z [Term] id: GO:0010969 name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion created_by: tanyaberardini creation_date: 2009-05-20T11:54:57Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport created_by: tanyaberardini creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010971 name: positive regulation of G2/M transition of mitotic cell cycle namespace: biological_process alt_id: GO:0031662 def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle" RELATED [] synonym: "positive regulation of mitotic entry" EXACT [GOC:mah] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle created_by: tanyaberardini creation_date: 2009-06-01T10:16:34Z [Term] id: GO:0010972 name: negative regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "negative regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle created_by: tanyaberardini creation_date: 2009-06-01T10:18:29Z [Term] id: GO:0010973 name: positive regulation of division septum assembly namespace: biological_process alt_id: GO:1901912 alt_id: GO:1902470 def: "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "positive regulation of division septum formation" EXACT [] synonym: "positive regulation of division septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic division septum assembly" EXACT [GOC:TermGenie] is_a: GO:0032955 ! regulation of division septum assembly is_a: GO:1901893 ! positive regulation of cell septum assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000917 ! division septum assembly relationship: positively_regulates GO:0000917 ! division septum assembly created_by: tanyaberardini creation_date: 2009-06-01T10:27:15Z [Term] id: GO:0010974 name: negative regulation of division septum assembly namespace: biological_process alt_id: GO:1901139 alt_id: GO:1902469 def: "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "inhibition of division septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie] synonym: "negative regulation of division septum formation" EXACT [] is_a: GO:0032955 ! regulation of division septum assembly is_a: GO:1901892 ! negative regulation of cell septum assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000917 ! division septum assembly relationship: negatively_regulates GO:0000917 ! division septum assembly created_by: tanyaberardini creation_date: 2009-06-01T10:32:32Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031175 ! neuron projection development relationship: regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0045666 ! positive regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031175 ! neuron projection development relationship: positively_regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0045665 ! negative regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031175 ! neuron projection development relationship: negatively_regulates GO:0031175 ! neuron projection development created_by: tanyaberardini creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0010978 name: gene silencing involved in chronological cell aging namespace: biological_process def: "Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0016458 ! gene silencing intersection_of: GO:0016458 ! gene silencing intersection_of: part_of GO:0001300 ! chronological cell aging relationship: part_of GO:0001300 ! chronological cell aging created_by: tanyaberardini creation_date: 2009-06-01T11:39:42Z [Term] id: GO:0010979 name: regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070576 ! vitamin D 24-hydroxylase activity relationship: regulates GO:0070576 ! vitamin D 24-hydroxylase activity created_by: tanyaberardini creation_date: 2009-06-01T11:44:54Z [Term] id: GO:0010980 name: positive regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity is_a: GO:0032770 ! positive regulation of monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070576 ! vitamin D 24-hydroxylase activity relationship: positively_regulates GO:0070576 ! vitamin D 24-hydroxylase activity created_by: tanyaberardini creation_date: 2009-06-01T11:47:19Z [Term] id: GO:0010981 name: regulation of cell wall macromolecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044036 ! cell wall macromolecule metabolic process relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process created_by: tanyaberardini creation_date: 2009-06-01T11:55:35Z [Term] id: GO:0010982 name: regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034384 ! high-density lipoprotein particle clearance relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:01:30Z [Term] id: GO:0010983 name: positive regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:03:32Z [Term] id: GO:0010984 name: regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034381 ! plasma lipoprotein particle clearance relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:05:12Z [Term] id: GO:0010985 name: negative regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:06:59Z [Term] id: GO:0010986 name: positive regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:08:19Z [Term] id: GO:0010987 name: negative regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:09:36Z [Term] id: GO:0010988 name: regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034383 ! low-density lipoprotein particle clearance relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:13:07Z [Term] id: GO:0010989 name: negative regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance created_by: tanyaberardini creation_date: 2009-06-01T12:15:07Z [Term] id: GO:0010990 name: regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007183 ! SMAD protein complex assembly relationship: regulates GO:0007183 ! SMAD protein complex assembly created_by: tanyaberardini creation_date: 2009-06-03T11:28:05Z [Term] id: GO:0010991 name: negative regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010990 ! regulation of SMAD protein complex assembly is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007183 ! SMAD protein complex assembly relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly created_by: tanyaberardini creation_date: 2009-06-03T11:30:44Z [Term] id: GO:0010992 name: ubiquitin recycling namespace: biological_process alt_id: GO:0010993 def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates." [GOC:BHF, GOC:dph, GOC:PG, GOC:tb, PMID:19410548] synonym: "regulation of ubiquitin homeostasis" NARROW [] synonym: "ubiquitin homeostasis" RELATED [] is_a: GO:0019725 ! cellular homeostasis created_by: tanyaberardini creation_date: 2009-06-03T11:36:55Z [Term] id: GO:0010994 name: free ubiquitin chain polymerization namespace: biological_process def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0010992 ! ubiquitin recycling created_by: tanyaberardini creation_date: 2009-06-03T11:41:03Z [Term] id: GO:0010995 name: free ubiquitin chain depolymerization namespace: biological_process def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0010992 ! ubiquitin recycling created_by: tanyaberardini creation_date: 2009-06-03T11:45:42Z [Term] id: GO:0010996 name: response to auditory stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0009612 ! response to mechanical stimulus created_by: tanyaberardini creation_date: 2009-06-10T11:09:38Z [Term] id: GO:0010997 name: anaphase-promoting complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] synonym: "APC binding" EXACT [GOC:dph, GOC:tb] is_a: GO:0044877 ! protein-containing complex binding created_by: tanyaberardini creation_date: 2009-06-10T11:18:22Z [Term] id: GO:0010998 name: regulation of translational initiation by eIF2 alpha phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] comment: Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'. synonym: "eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] synonym: "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0043558 ! regulation of translational initiation in response to stress created_by: tanyaberardini creation_date: 2009-06-10T11:27:47Z [Term] id: GO:0010999 name: regulation of eIF2 alpha phosphorylation by heme namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation created_by: tanyaberardini creation_date: 2009-06-10T11:42:10Z [Term] id: GO:0011000 name: replication fork arrest at mating type locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest created_by: tanyaberardini creation_date: 2009-06-24T12:02:48Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death [Term] id: GO:0012502 name: induction of programmed cell death namespace: biological_process alt_id: GO:0012503 def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr] synonym: "induction of non-apoptotic programmed cell death" NARROW [] synonym: "induction of nonapoptotic programmed cell death" NARROW [] is_a: GO:0043068 ! positive regulation of programmed cell death [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0012507 name: ER to Golgi transport vesicle membrane namespace: cellular_component alt_id: GO:0030664 def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII coated vesicle membrane" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "ER-Golgi transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030134 ! COPII-coated ER to Golgi transport vesicle [Term] id: GO:0012508 name: Golgi to ER transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi to ER constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-ER transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI-coated vesicle membrane relationship: part_of GO:0030142 ! COPI-coated Golgi to ER transport vesicle [Term] id: GO:0012509 name: inter-Golgi transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI-coated vesicle membrane relationship: part_of GO:0030143 ! COPI-coated inter-Golgi transport vesicle [Term] id: GO:0012510 name: trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] synonym: "TGN transport vesicle membrane" EXACT [] synonym: "trans-Golgi network constitutive secretory pathway transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0012511 name: monolayer-surrounded lipid storage body namespace: cellular_component alt_id: GO:0009520 def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] synonym: "oil body" EXACT [] synonym: "oilbody" EXACT [] synonym: "oleosome" EXACT [] synonym: "spherosome" EXACT [] xref: Wikipedia:Oil_body is_a: GO:0005811 ! lipid droplet [Term] id: GO:0014001 name: sclerenchyma cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0014002 name: astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] synonym: "astrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048708 ! astrocyte differentiation [Term] id: GO:0014003 name: oligodendrocyte development namespace: biological_process def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] synonym: "oligodendrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0014004 name: microglia differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] synonym: "microglial cell differentiation" EXACT [] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0030225 ! macrophage differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014005 name: microglia development namespace: biological_process def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] synonym: "microglial cell development" EXACT [] is_a: GO:0021782 ! glial cell development is_a: GO:0061515 ! myeloid cell development relationship: part_of GO:0014004 ! microglia differentiation [Term] id: GO:0014006 name: regulation of microglia differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "regulation of microglial cell differentiation" EXACT [] is_a: GO:0045649 ! regulation of macrophage differentiation is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014004 ! microglia differentiation relationship: regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014007 name: negative regulation of microglia differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "down regulation of microglia differentiation" EXACT [] synonym: "down-regulation of microglia differentiation" EXACT [] synonym: "downregulation of microglia differentiation" EXACT [] synonym: "inhibition of microglia differentiation" NARROW [] synonym: "negative regulation of microglial cell differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045650 ! negative regulation of macrophage differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014004 ! microglia differentiation relationship: negatively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014008 name: positive regulation of microglia differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "activation of microglia differentiation" NARROW [] synonym: "positive regulation of microglial cell differentiation" EXACT [] synonym: "stimulation of microglia differentiation" NARROW [] synonym: "up regulation of microglia differentiation" EXACT [] synonym: "up-regulation of microglia differentiation" EXACT [] synonym: "upregulation of microglia differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045651 ! positive regulation of macrophage differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014004 ! microglia differentiation relationship: positively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation [Term] id: GO:0014011 name: Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014010 ! Schwann cell proliferation intersection_of: GO:0014010 ! Schwann cell proliferation intersection_of: part_of GO:0031103 ! axon regeneration relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration [Term] id: GO:0014012 name: peripheral nervous system axon regeneration namespace: biological_process def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] synonym: "axon regeneration in peripheral nervous system" EXACT [] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042063 ! gliogenesis relationship: regulates GO:0042063 ! gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042063 ! gliogenesis relationship: negatively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042063 ! gliogenesis relationship: positively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0014017 name: neuroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] is_a: GO:0048865 ! stem cell fate commitment relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014018 name: neuroblast fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] is_a: GO:0048866 ! stem cell fate specification relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048864 ! stem cell development relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014021 name: secondary neural tube formation namespace: biological_process alt_id: GO:0014026 def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585] synonym: "medullary cord biosynthesis" EXACT [] synonym: "medullary cord formation" EXACT [] synonym: "neural rod formation" RELATED [] synonym: "secondary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014022 name: neural plate elongation namespace: biological_process def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014024 name: neural rod cavitation namespace: biological_process def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014023 ! neural rod formation [Term] id: GO:0014027 name: secondary neural tube rod cavitation namespace: biological_process def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] synonym: "medullary rod cavitation" EXACT [] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014021 ! secondary neural tube formation [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0048570 ! notochord morphogenesis [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0014030 name: mesenchymal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0014031 ! mesenchymal cell development is_a: GO:0048864 ! stem cell development relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0014034 name: neural crest cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048865 ! stem cell fate commitment relationship: part_of GO:0014029 ! neural crest formation relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014035 name: neural crest cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014036 name: neural crest cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef] is_a: GO:0048866 ! stem cell fate specification relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014037 name: Schwann cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0014038 name: regulation of Schwann cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014037 ! Schwann cell differentiation relationship: regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014039 name: negative regulation of Schwann cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "down regulation of Schwann cell differentiation" EXACT [] synonym: "down-regulation of Schwann cell differentiation" EXACT [] synonym: "downregulation of Schwann cell differentiation" EXACT [] synonym: "inhibition of Schwann cell differentiation" NARROW [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014037 ! Schwann cell differentiation relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014040 name: positive regulation of Schwann cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "activation of Schwann cell differentiation" NARROW [] synonym: "stimulation of Schwann cell differentiation" NARROW [] synonym: "up regulation of Schwann cell differentiation" EXACT [] synonym: "up-regulation of Schwann cell differentiation" EXACT [] synonym: "upregulation of Schwann cell differentiation" EXACT [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014037 ! Schwann cell differentiation relationship: positively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042551 ! neuron maturation relationship: regulates GO:0042551 ! neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042551 ! neuron maturation relationship: positively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042551 ! neuron maturation relationship: negatively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014044 name: Schwann cell development namespace: biological_process def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014045 name: establishment of endothelial blood-brain barrier namespace: biological_process def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] synonym: "establishment of endothelial BBB" EXACT [PMID:20080302] synonym: "establishment of endothelial blood/brain barrier" EXACT [] is_a: GO:0060856 ! establishment of blood-brain barrier is_a: GO:0061028 ! establishment of endothelial barrier relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014046 name: dopamine secretion namespace: biological_process def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] is_a: GO:0015872 ! dopamine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0014047 name: glutamate secretion namespace: biological_process def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0014048 name: regulation of glutamate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014047 ! glutamate secretion relationship: regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014049 name: positive regulation of glutamate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "activation of glutamate secretion" NARROW [] synonym: "stimulation of glutamate secretion" NARROW [] synonym: "up regulation of glutamate secretion" EXACT [] synonym: "up-regulation of glutamate secretion" EXACT [] synonym: "upregulation of glutamate secretion" EXACT [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014047 ! glutamate secretion relationship: positively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014050 name: negative regulation of glutamate secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "down regulation of glutamate secretion" EXACT [] synonym: "down-regulation of glutamate secretion" EXACT [] synonym: "downregulation of glutamate secretion" EXACT [] synonym: "inhibition of glutamate secretion" NARROW [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014047 ! glutamate secretion relationship: negatively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] synonym: "GABA secretion" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0014052 name: regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014051 ! gamma-aminobutyric acid secretion relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014053 name: negative regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014054 name: positive regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] synonym: "positive regulation of GABA secretion" EXACT [] synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission namespace: biological_process def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion intersection_of: GO:0061526 ! acetylcholine secretion intersection_of: part_of GO:0007271 ! synaptic transmission, cholinergic relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0014056 name: regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0043269 ! regulation of ion transport is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014059 name: regulation of dopamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014046 ! dopamine secretion relationship: regulates GO:0014046 ! dopamine secretion [Term] id: GO:0014060 name: regulation of epinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] synonym: "regulation of adrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048242 ! epinephrine secretion relationship: regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048243 ! norepinephrine secretion relationship: regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001820 ! serotonin secretion relationship: regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001820 ! serotonin secretion relationship: negatively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001820 ! serotonin secretion relationship: positively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014065 name: phosphatidylinositol 3-kinase signaling namespace: biological_process def: "A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K] synonym: "phosphatidylinositol 3-kinase cascade" RELATED [GOC:signaling] synonym: "phosphatidylinositol 3-kinase signal transduction" EXACT [GOC:signaling] synonym: "phosphoinositide 3-kinase cascade" EXACT [] synonym: "PI 3-kinase cascade" EXACT [] synonym: "PI3K cascade" EXACT [] synonym: "PI3K signal transduction" EXACT [GOC:signaling] synonym: "PI3K signaling" EXACT [GOC:signaling] is_a: GO:0048015 ! phosphatidylinositol-mediated signaling [Term] id: GO:0014066 name: regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT [] synonym: "regulation of PI 3-kinase cascade" RELATED [] synonym: "regulation of PI3K cascade" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling relationship: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014067 name: negative regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "negative regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT [] synonym: "negative regulation of PI 3-kinase cascade" EXACT [] synonym: "negative regulation of PI3K cascade" EXACT [] is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling relationship: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014068 name: positive regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "activation of phosphoinositide 3-kinase cascade" NARROW [] synonym: "positive regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT [] synonym: "positive regulation of PI 3-kinase cascade" EXACT [] synonym: "positive regulation of PI3K cascade" EXACT [] synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT [] is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling relationship: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014069 name: postsynaptic density namespace: cellular_component alt_id: GO:0097481 alt_id: GO:0097483 def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] subset: goslim_synapse synonym: "neuronal postsynaptic density" EXACT [GO:0097481] synonym: "post synaptic density" EXACT [] synonym: "post-synaptic density" EXACT [] synonym: "postsynaptic density of dendrite" NARROW [] xref: NIF_Subcellular:sao1196688972 xref: Wikipedia:Postsynaptic_density is_a: GO:0099572 ! postsynaptic specialization intersection_of: GO:0099572 ! postsynaptic specialization intersection_of: part_of GO:0032279 ! asymmetric synapse relationship: part_of GO:0032279 ! asymmetric synapse created_by: paola creation_date: 2013-07-02T09:44:28Z [Term] id: GO:0014070 name: response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef] synonym: "response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0014071 name: response to cycloalkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014072 name: response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014073 name: response to tropane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014074 name: response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef] synonym: "response to purine" RELATED [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0014076 name: response to fluoxetine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:ef, GOC:pr] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to selective serotonin reuptake inhibitor" RELATED [] synonym: "response to SSRI" RELATED [] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0036276 ! response to antidepressant [Term] id: GO:0014701 name: junctional sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014702 name: free sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014703 name: oscillatory muscle contraction namespace: biological_process def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014704 name: intercalated disc namespace: cellular_component def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] synonym: "intercalated disk" EXACT [] xref: Wikipedia:Intercalated_disc is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0014705 name: C zone namespace: cellular_component def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031672 ! A band [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0014707 name: branchiomeric skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] is_a: GO:0007517 ! muscle organ development is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014708 name: regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle] is_a: GO:0048634 ! regulation of muscle organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002075 ! somitomeric trunk muscle development relationship: regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014709 name: positive regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048636 ! positive regulation of muscle organ development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002075 ! somitomeric trunk muscle development relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014710 name: negative regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048635 ! negative regulation of muscle organ development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002075 ! somitomeric trunk muscle development relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014711 name: regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014707 ! branchiomeric skeletal muscle development relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014712 name: positive regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014713 name: negative regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014714 name: myoblast fate commitment in head namespace: biological_process def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast fate commitment [Term] id: GO:0014715 name: myoblast fate commitment in trunk namespace: biological_process def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast fate commitment [Term] id: GO:0014716 name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration namespace: biological_process def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle] comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class. synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT [] is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division intersection_of: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [Term] id: GO:0014717 name: regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014718 name: positive regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014719 name: skeletal muscle satellite cell activation namespace: biological_process def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905] is_a: GO:0001775 ! cell activation [Term] id: GO:0014720 name: tonic skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014721 name: twitch skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014722 name: regulation of skeletal muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0019722 ! calcium-mediated signaling intersection_of: GO:0019722 ! calcium-mediated signaling intersection_of: regulates GO:0003009 ! skeletal muscle contraction [Term] id: GO:0014723 name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle] synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT [] is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014724 name: regulation of twitch skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014721 ! twitch skeletal muscle contraction relationship: regulates GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0014725 name: regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002074 ! extraocular skeletal muscle development relationship: regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014726 name: negative regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002074 ! extraocular skeletal muscle development relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014727 name: positive regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002074 ! extraocular skeletal muscle development relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014728 name: regulation of the force of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion [Term] id: GO:0014729 name: regulation of the velocity of shortening of skeletal muscle modulating contraction namespace: biological_process def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle] synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014730 name: skeletal muscle regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle] is_a: GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014731 name: spectrin-associated cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0014732 name: skeletal muscle atrophy namespace: biological_process def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014891 ! striated muscle atrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043501 ! skeletal muscle adaptation relationship: regulates GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014735 name: regulation of muscle atrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014889 ! muscle atrophy relationship: regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014736 name: negative regulation of muscle atrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014889 ! muscle atrophy relationship: negatively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014737 name: positive regulation of muscle atrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014889 ! muscle atrophy relationship: positively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014738 name: regulation of muscle hyperplasia namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014900 ! muscle hyperplasia relationship: regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014739 name: positive regulation of muscle hyperplasia namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014900 ! muscle hyperplasia relationship: positively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014740 name: negative regulation of muscle hyperplasia namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014900 ! muscle hyperplasia relationship: negatively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014896 ! muscle hypertrophy relationship: negatively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014896 ! muscle hypertrophy relationship: positively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014896 ! muscle hypertrophy relationship: regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043500 ! muscle adaptation relationship: positively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043500 ! muscle adaptation relationship: negatively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014746 name: regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014720 ! tonic skeletal muscle contraction relationship: regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014747 name: positive regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014720 ! tonic skeletal muscle contraction relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014748 name: negative regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014801 name: longitudinal sarcoplasmic reticulum namespace: cellular_component def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014802 name: terminal cisterna namespace: cellular_component def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] xref: Wikipedia:Terminal_cisterna is_a: GO:0098827 ! endoplasmic reticulum subcompartment relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014803 name: longitudinal sarcoplasmic reticulum lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum [Term] id: GO:0014804 name: terminal cisterna lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0014802 ! terminal cisterna relationship: part_of GO:0014802 ! terminal cisterna [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014806 name: smooth muscle hyperplasia namespace: biological_process def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014900 ! muscle hyperplasia [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001756 ! somitogenesis relationship: regulates GO:0001756 ! somitogenesis [Term] id: GO:0014808 name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle] synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb] is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport is_a: GO:1903514 ! release of sequestered calcium ion into cytosol by endoplasmic reticulum [Term] id: GO:0014809 name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014810 name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045989 ! positive regulation of striated muscle contraction [Term] id: GO:0014811 name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045988 ! negative regulation of striated muscle contraction [Term] id: GO:0014812 name: muscle cell migration namespace: biological_process def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] is_a: GO:0016477 ! cell migration [Term] id: GO:0014813 name: skeletal muscle satellite cell commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0014816 ! skeletal muscle satellite cell differentiation [Term] id: GO:0014814 name: axon regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014815 name: initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration namespace: biological_process def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014816 name: skeletal muscle satellite cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0035914 ! skeletal muscle cell differentiation [Term] id: GO:0014817 name: skeletal muscle satellite cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment [Term] id: GO:0014818 name: skeletal muscle satellite cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003009 ! skeletal muscle contraction relationship: regulates GO:0003009 ! skeletal muscle contraction [Term] id: GO:0014820 name: tonic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014821 name: phasic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014822 name: detection of wounding namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle] synonym: "detection of injury" EXACT [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009611 ! response to wounding [Term] id: GO:0014823 name: response to activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle] synonym: "response to exercise" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014824 name: artery smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014825 name: stomach fundus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612] is_a: GO:0014847 ! proximal stomach smooth muscle contraction [Term] id: GO:0014826 name: vein smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014827 name: intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014828 name: distal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0120063 ! stomach smooth muscle contraction [Term] id: GO:0014829 name: vascular smooth muscle contraction namespace: biological_process def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0042310 ! vasoconstriction [Term] id: GO:0014830 name: arteriole smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MSH:D001160] is_a: GO:0014824 ! artery smooth muscle contraction [Term] id: GO:0014831 name: gastro-intestinal system smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014832 name: urinary bladder smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, http://en.wikipedia.org/wiki/Rhea_(bird), MA:0001697, MSH:D001743, PMID:11768524, PMID:18276178, PMID:538956] is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014833 name: skeletal muscle satellite stem cell asymmetric division namespace: biological_process def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "satellite cell asymmetric division" EXACT [] is_a: GO:0098722 ! asymmetric stem cell division relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014834 name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905] synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] synonym: "satellite cell population maintenance" EXACT [] synonym: "satellite cell self-renewal" BROAD [] is_a: GO:0098727 ! maintenance of cell number relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014835 name: myoblast differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045445 ! myoblast differentiation intersection_of: GO:0045445 ! myoblast differentiation intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014836 name: myoblast fate commitment involved in skeletal muscle regeneration namespace: biological_process def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048625 ! myoblast fate commitment intersection_of: GO:0048625 ! myoblast fate commitment intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014835 ! myoblast differentiation involved in skeletal muscle regeneration [Term] id: GO:0014837 name: myoblast fate determination involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0007518 ! myoblast fate determination intersection_of: GO:0007518 ! myoblast fate determination intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014838 name: myoblast fate specification involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048626 ! myoblast fate specification intersection_of: GO:0048626 ! myoblast fate specification intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014839 name: myoblast migration involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] is_a: GO:0051451 ! myoblast migration intersection_of: GO:0051451 ! myoblast migration intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014841 name: skeletal muscle satellite cell proliferation namespace: biological_process def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014842 name: regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014841 ! skeletal muscle satellite cell proliferation relationship: regulates GO:0014841 ! skeletal muscle satellite cell proliferation [Term] id: GO:0014843 name: growth factor dependent regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation [Term] id: GO:0014844 name: myoblast proliferation involved in skeletal muscle regeneration namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0051450 ! myoblast proliferation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014845 name: stomach body smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559] is_a: GO:0014828 ! distal stomach smooth muscle contraction [Term] id: GO:0014846 name: esophagus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742] synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph] is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014847 name: proximal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0120063 ! stomach smooth muscle contraction [Term] id: GO:0014848 name: urinary tract smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014849 name: ureter smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014850 name: response to muscle activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014853 name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction namespace: biological_process def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT [] is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: part_of GO:0003009 ! skeletal muscle contraction relationship: part_of GO:0003009 ! skeletal muscle contraction relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014854 name: response to inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014856 ! skeletal muscle cell proliferation relationship: regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014856 ! skeletal muscle cell proliferation relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: part_of GO:0014819 ! regulation of skeletal muscle contraction relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential [Term] id: GO:0014862 name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014863 name: detection of inactivity namespace: biological_process def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014864 name: detection of muscle activity namespace: biological_process def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014865 ! detection of activity [Term] id: GO:0014865 name: detection of activity namespace: biological_process def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly [Term] id: GO:0014868 name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014869 name: detection of muscle inactivity namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014863 ! detection of inactivity is_a: GO:0014870 ! response to muscle inactivity [Term] id: GO:0014870 name: response to muscle inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity [Term] id: GO:0014871 name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: GO:0051301 ! cell division [Term] id: GO:0014873 name: response to muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to fatigue" EXACT [] synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation intersection_of: GO:0014850 ! response to muscle activity intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation relationship: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014875 name: detection of muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of fatigue" EXACT [] is_a: GO:0014864 ! detection of muscle activity is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation intersection_of: GO:0014864 ! detection of muscle activity intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014876 name: response to injury involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0009611 ! response to wounding is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014877 name: response to muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014870 ! response to muscle inactivity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation intersection_of: GO:0014870 ! response to muscle inactivity intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014878 name: response to electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation is_a: GO:0051602 ! response to electrical stimulus intersection_of: GO:0051602 ! response to electrical stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014879 name: detection of electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014880 name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction [Term] id: GO:0014881 name: regulation of myofibril size namespace: biological_process def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril size" EXACT [] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0014882 name: regulation of myofibril number namespace: biological_process def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril number" EXACT [] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014883 name: transition between fast and slow fiber namespace: biological_process def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between fast and slow fibre" EXACT [] synonym: "transition fast-slow fiber" EXACT [] synonym: "transition fast-slow fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014884 name: detection of muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014869 ! detection of muscle inactivity is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation intersection_of: GO:0014869 ! detection of muscle inactivity intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014885 name: detection of injury involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014822 ! detection of wounding is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation intersection_of: GO:0014822 ! detection of wounding intersection_of: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014886 name: transition between slow and fast fiber namespace: biological_process def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between slow and fast fibre" EXACT [] synonym: "transition slow-fast fiber" EXACT [] synonym: "transition slow-fast fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014889 name: muscle atrophy namespace: biological_process def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] comment: GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process. xref: Wikipedia:Muscle_atrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014890 name: smooth muscle atrophy namespace: biological_process def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014891 name: striated muscle atrophy namespace: biological_process def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014888 ! striated muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014893 name: response to rest involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014894 name: response to denervation involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: GO:0003012 ! muscle system process [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014898 name: cardiac muscle hypertrophy in response to stress namespace: biological_process def: "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] is_a: GO:0003299 ! muscle hypertrophy in response to stress is_a: GO:0003300 ! cardiac muscle hypertrophy is_a: GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0014899 name: cardiac muscle atrophy namespace: biological_process def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] is_a: GO:0014887 ! cardiac muscle adaptation is_a: GO:0014891 ! striated muscle atrophy [Term] id: GO:0014900 name: muscle hyperplasia namespace: biological_process def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014901 name: satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0014719 ! skeletal muscle satellite cell activation intersection_of: GO:0014719 ! skeletal muscle satellite cell activation intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0055002 ! striated muscle cell development relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0014905 name: myoblast fusion involved in skeletal muscle regeneration namespace: biological_process def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0007520 ! myoblast fusion intersection_of: GO:0007520 ! myoblast fusion intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014906 name: myotube cell development involved in skeletal muscle regeneration namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014904 ! myotube cell development intersection_of: GO:0014904 ! myotube cell development intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014908 name: myotube differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014902 ! myotube differentiation intersection_of: GO:0014902 ! myotube differentiation intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014909 name: smooth muscle cell migration namespace: biological_process def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration [Term] id: GO:0014910 name: regulation of smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014909 ! smooth muscle cell migration relationship: regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014911 name: positive regulation of smooth muscle cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014909 ! smooth muscle cell migration relationship: positively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014912 name: negative regulation of smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014909 ! smooth muscle cell migration relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014914 name: myoblast maturation involved in muscle regeneration namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048628 ! myoblast maturation [Term] id: GO:0014915 name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction is_a: GO:0032972 ! regulation of muscle filament sliding speed [Term] id: GO:0014916 name: regulation of lung blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] synonym: "regulation of pulmonary blood pressure" EXACT [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0014917 name: obsolete positive regulation of diuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of diuresis by pressure natriuresis" EXACT [] is_obsolete: true replaced_by: GO:0035818 [Term] id: GO:0014918 name: obsolete positive regulation of natriuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of natriuresis by pressure natriuresis" EXACT [] is_obsolete: true replaced_by: GO:0035819 [Term] id: GO:0015000 name: obsolete polyferredoxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "polyferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015001 name: obsolete high-potential iron-sulfur carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "high-potential iron-sulfur carrier" EXACT [] synonym: "high-potential iron-sulphur carrier" EXACT [] synonym: "HiPIP" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015002 name: heme-copper terminal oxidase activity namespace: molecular_function def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] synonym: "haem-copper terminal oxidase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015003 name: obsolete copper electron carrier namespace: molecular_function def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "copper electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015004 name: obsolete small blue copper electron carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "small blue copper electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015005 name: obsolete azurin namespace: molecular_function def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "azurin" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0015006 name: obsolete plastocyanin namespace: molecular_function def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "plastocyanin" EXACT [] is_obsolete: true replaced_by: GO:0046028 [Term] id: GO:0015007 name: obsolete electron carrier, chlorophyll electron transport system namespace: molecular_function def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732] comment: This term was made obsolete because it contains both process and function information. synonym: "chlorophyll electron carrier" RELATED [] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] is_obsolete: true consider: GO:0009055 consider: GO:0009767 [Term] id: GO:0015009 name: corrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732] synonym: "corrin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0015010 name: tetrahydrocorphin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44] synonym: "tetrahydrocorphin metabolism" EXACT [] is_a: GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process [Term] id: GO:0015011 name: nickel-tetrapyrrole coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33] synonym: "coenzyme F430 metabolic process" NARROW [] synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process [Term] id: GO:0015012 name: heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] synonym: "heparan sulfate proteoglycan anabolism" EXACT [] synonym: "heparan sulfate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process" RELATED [] xref: RESID:AA0210 is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process [Term] id: GO:0015013 name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide namespace: biological_process def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194] synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT [] synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED [] is_a: GO:0018242 ! protein O-linked glycosylation via serine is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015014 name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "heparan sulfate proteoglycan chain elongation" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015015 name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification namespace: biological_process def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194] synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT [] synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED [] is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015016 name: [heparan sulfate]-glucosamine N-sulfotransferase activity namespace: molecular_function alt_id: GO:0004393 alt_id: GO:0015022 alt_id: GO:0051910 def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8] comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] synonym: "desulfoheparin sulfotransferase activity" EXACT [] synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulphotransferase activity" EXACT [] synonym: "heparitin sulfotransferase activity" EXACT [] synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-HSST activity" EXACT [EC:2.8.2.8] synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] xref: EC:2.8.2.8 xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0015017 name: obsolete glypican namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan'). synonym: "glypican" EXACT [] is_obsolete: true [Term] id: GO:0015018 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135] xref: EC:2.4.1.135 xref: MetaCyc:2.4.1.135-RXN xref: Reactome:R-HSA-1889955 "B3GAT dimers transfer GlcA to tetrasaccharide linker" xref: Reactome:R-HSA-3560802 "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker" xref: Reactome:R-HSA-9638064 "B3GAT3 dimer transfers GlcA to tetrasaccharide linker" is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0015019 name: heparan-alpha-glucosaminide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED [] xref: EC:2.3.1.78 xref: MetaCyc:2.3.1.78-RXN xref: Reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3)" xref: Reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)" xref: Reactome:R-HSA-2263492 "Defective HGSNAT does not acetylate Heparan chain(1)" xref: Reactome:R-HSA-9036056 "Defective HGSNAT does not acetylate Heparan sulfate chain(3)" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0015020 name: glucuronosyltransferase activity namespace: molecular_function alt_id: GO:0003981 def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "GT activity" EXACT [EC:2.4.1.17] synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [EC:2.4.1.17] synonym: "UDPGT activity" EXACT [EC:2.4.1.17] synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] xref: EC:2.4.1.17 xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-159179 "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG" xref: Reactome:R-HSA-159194 "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG" xref: Reactome:R-HSA-174916 "Formation of N-glucuronides" xref: Reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates" xref: Reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP" xref: Reactome:R-HSA-5604954 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL" xref: Reactome:R-HSA-5604975 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL" xref: Reactome:R-HSA-5617143 "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA" xref: Reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN" xref: Reactome:R-HSA-9036102 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG" xref: Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG" xref: Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG" xref: Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG" xref: Reactome:R-HSA-9638097 "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0015021 name: heparin-sulfate lyase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] synonym: "[heparan sulfate]-sulfate lyase activity" RELATED [] synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] synonym: "heparin-sulphate lyase activity" EXACT [] synonym: "heparitin-sulfate lyase activity" EXACT [] synonym: "heparitinase I" RELATED [EC:4.2.2.8] synonym: "heparitinase II" RELATED [EC:4.2.2.8] xref: EC:4.2.2.8 xref: MetaCyc:4.2.2.8-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0015023 name: obsolete syndecan namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "syndecan" EXACT [] is_obsolete: true [Term] id: GO:0015024 name: glucuronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "glucuronate-2-sulphatase activity" EXACT [] synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18] xref: EC:3.1.6.18 xref: MetaCyc:3.1.6.18-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0015025 name: obsolete GPI-anchored membrane-bound receptor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "GPI-anchored membrane-bound receptor" EXACT [] is_obsolete: true replaced_by: GO:0031225 [Term] id: GO:0015026 name: coreceptor activity namespace: molecular_function alt_id: GO:0015027 alt_id: GO:0015028 def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah] synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0015029 name: obsolete internalization receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind. synonym: "internalization receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0015030 name: Cajal body namespace: cellular_component def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] synonym: "coiled body" EXACT [] synonym: "Gemini of coiled bodies" RELATED [] synonym: "Gems" RELATED [] xref: NIF_Subcellular:nlx_subcell_090901 xref: Wikipedia:Cajal_body is_a: GO:0016604 ! nuclear body [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] xref: MIPS_funcat:14 xref: MIPS_funcat:14.04 xref: MIPS_funcat:20.01.10 is_a: GO:0015833 ! peptide transport is_a: GO:0045184 ! establishment of protein localization [Term] id: GO:0015032 name: obsolete storage protein import into fat body namespace: biological_process def: "OBSOLETE. The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363] comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using 'receptor-mediated endocytosis', https://github.com/geneontology/go-ontology/issues/12935 synonym: "fat body metabolic process" BROAD [] synonym: "fat body metabolism" BROAD [] synonym: "fat body storage protein uptake" EXACT [] synonym: "import of storage protein into fat body" EXACT [] synonym: "storage protein import by fat body cells" EXACT [] synonym: "storage protein import into fat body cells" EXACT [] synonym: "storage protein transport into fat body cells" EXACT [] synonym: "storage protein uptake into fat body cells" EXACT [] is_obsolete: true [Term] id: GO:0015034 name: obsolete cytochrome P450 activity namespace: molecular_function def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423] comment: This term was made obsolete because it is a grouping term representing a set of gene products. synonym: "cytochrome P450 activity" EXACT [] is_obsolete: true consider: GO:0019825 [Term] id: GO:0015035 name: protein disulfide oxidoreductase activity namespace: molecular_function alt_id: GO:0008895 def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] synonym: "haem lyase disulphide oxidoreductase activity" NARROW [] synonym: "heme lyase disulfide oxidoreductase activity" NARROW [] synonym: "protein disulphide oxidoreductase activity" EXACT [] synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw] xref: MetaCyc:DISULFOXRED-RXN xref: Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds" xref: Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1" is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015036 name: disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] synonym: "disulphide oxidoreductase activity" EXACT [] xref: Reactome:R-HSA-1222417 "TrxA reactivates AhpC" xref: Reactome:R-HSA-1222644 "TrxA/B1 reactivates Tpx" xref: Reactome:R-HSA-1222655 "AhpD reactivates AhpC" xref: Reactome:R-HSA-1222690 "DlaT reactivates AhpD" xref: Reactome:R-HSA-264997 "Oxidation of cysteine to cystine in Proinsulin" is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0015037 name: peptide disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN] synonym: "peptide disulphide oxidoreductase activity" EXACT [] is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015038 name: glutathione disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] synonym: "glutaredoxin" RELATED [] synonym: "glutathione disulphide oxidoreductase activity" EXACT [] xref: Reactome:R-HSA-111746 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)" is_a: GO:0015037 ! peptide disulfide oxidoreductase activity [Term] id: GO:0015039 name: NADPH-adrenodoxin reductase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.6, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.6 xref: MetaCyc:RXN-13685 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015040 name: obsolete electron transfer flavoprotein, group I namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein, group I" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015041 name: obsolete electron transfer flavoprotein, group II namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein, group II" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015042 name: trypanothione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12] comment: Note that this function was formerly EC:1.6.4.8. synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "trypanothione reductase activity" EXACT [] synonym: "trypanothione-disulphide reductase activity" EXACT [] synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12] xref: EC:1.8.1.12 xref: MetaCyc:1.8.1.12-RXN xref: RHEA:16757 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0015043 name: leghemoglobin reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6] synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6] xref: EC:1.6.2.6 xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0015044 name: rubredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin reductase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] xref: EC:1.18.1.1 xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity [Term] id: GO:0015045 name: rubredoxin-NAD(P)+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NADPH:rubredoxin reductase activity" EXACT [] synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4] synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4] xref: EC:1.18.1.4 xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015046 name: rubredoxin-NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-] xref: EC:1.18.1 is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity [Term] id: GO:0015047 name: NADPH-cytochrome-c2 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5] synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] xref: EC:1.6.2.5 xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0015048 name: phthalate dioxygenase reductase activity namespace: molecular_function def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015049 name: methane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25] synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25] synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25] xref: EC:1.14.13.25 xref: KEGG_REACTION:R01142 xref: KEGG_REACTION:R01143 xref: MetaCyc:METHANE-MONOOXYGENASE-RXN xref: RHEA:13637 xref: RHEA:13641 xref: UM-BBD_enzymeID:e0007 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0015050 name: methane monooxygenase complex namespace: cellular_component def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0015051 name: obsolete X-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "X-opioid receptor activity" EXACT [] is_obsolete: true consider: GO:0001626 [Term] id: GO:0015052 name: beta3-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta3 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0015053 name: obsolete opsin namespace: molecular_function def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684] comment: This term was made obsolete because it refers to a class of proteins. synonym: "opsin" EXACT [] is_obsolete: true consider: GO:0007602 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015054 name: gastrin receptor activity namespace: molecular_function def: "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity." [GOC:ai, GOC:signaling] synonym: "cholecystokinin-B receptor activity" RELATED [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0015055 name: secretin receptor activity namespace: molecular_function def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0015056 name: corticotrophin-releasing factor receptor activity namespace: molecular_function def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: part_of GO:0071376 ! cellular response to corticotropin-releasing hormone stimulus [Term] id: GO:0015057 name: thrombin-activated receptor activity namespace: molecular_function alt_id: GO:0010655 def: "A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it." [GOC:ai, GOC:pg, PMID:20423334] synonym: "thrombin receptor activity" EXACT [] synonym: "thrombin receptor activity, G-protein coupled" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0070493 ! thrombin-activated receptor signaling pathway [Term] id: GO:0015058 name: obsolete epidermal growth factor-like module containing hormone receptor activity namespace: molecular_function alt_id: GO:0016523 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "EGF-like module containing hormone receptor activity" EXACT [] synonym: "Egr1 hormone receptor" EXACT [] synonym: "epidermal growth factor-like module containing hormone receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0015059 name: obsolete blue-sensitive opsin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "blue-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015060 name: obsolete green-sensitive opsin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "green-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015061 name: obsolete red-sensitive opsin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "red-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009585 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015062 name: obsolete violet-sensitive opsin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "violet-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015063 name: obsolete long-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "long-wave-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015064 name: obsolete UV-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "UV-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007604 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015065 name: uridine nucleotide receptor activity namespace: molecular_function def: "Combining with UTP or UDP to initiate a change in cell activity." [GOC:curators, PMID:8537335] synonym: "purinoceptor type U" EXACT [] is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity [Term] id: GO:0015066 name: alpha-amylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004556 ! alpha-amylase activity [Term] id: GO:0015067 name: amidinotransferase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] synonym: "transamidinase activity" EXACT [] xref: EC:2.1.4 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0015068 name: glycine amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1] synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1] synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1] xref: EC:2.1.4.1 xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN xref: Reactome:R-HSA-71275 "arginine + glycine => ornithine + guanidoacetate" xref: RHEA:13201 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015069 name: scyllo-inosamine-4-phosphate amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [EC:2.1.4.2, RHEA:13265] synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2] xref: EC:2.1.4.2 xref: KEGG_REACTION:R03477 xref: MetaCyc:2.1.4.2-RXN xref: RHEA:13265 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015070 name: obsolete toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl] comment: This term was made obsolete because it represents a classification of molecules and not a molecular function. synonym: "toxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0015072 name: obsolete phosphatidylinositol 3-kinase, class I, catalyst activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0015073 name: obsolete phosphatidylinositol 3-kinase, class I, regulator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it refers to a class of gene products. synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0046935 [Term] id: GO:0015074 name: DNA integration namespace: biological_process def: "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] subset: goslim_pir xref: MIPS_funcat:10.01.05.03.05 is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0015075 name: ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0034220 ! ion transmembrane transport [Term] id: GO:0015076 name: obsolete heavy metal ion transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal ion transporter activity" EXACT [] is_obsolete: true consider: GO:0046873 [Term] id: GO:0015077 name: monovalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0015672 ! monovalent inorganic cation transport [Term] id: GO:0015078 name: proton transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] synonym: "hydrogen ion transmembrane transporter activity" EXACT [] synonym: "proton transporter activity" EXACT [] xref: Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase" xref: Reactome:R-HSA-164834 "Enzyme-bound ATP is released" xref: Reactome:R-HSA-170026 "Protons are translocated from the intermembrane space to the matrix" xref: Reactome:R-HSA-74723 "Endosome acidification" xref: Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity relationship: part_of GO:1902600 ! proton transmembrane transport [Term] id: GO:0015079 name: potassium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0015388 alt_id: GO:0022817 def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] synonym: "potassium transporter activity" EXACT [] synonym: "potassium uptake permease activity" RELATED [] synonym: "potassium uptake transmembrane transporter activity" RELATED [] xref: RHEA:29463 is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:0071805 ! potassium ion transmembrane transport [Term] id: GO:0015080 name: silver ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] synonym: "silver transporter activity" EXACT [] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:1902601 ! silver ion transmembrane transport [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022816 def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] synonym: "sodium transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:0035725 ! sodium ion transmembrane transport [Term] id: GO:0015083 name: aluminum ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0015084 def: "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aluminium ion transporter activity" EXACT [] synonym: "aluminium resistance permease activity" EXACT [] synonym: "aluminum resistance permease activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:1902602 ! aluminum ion transmembrane transport [Term] id: GO:0015085 name: calcium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] xref: Reactome:R-HSA-2534359 "CatSper Channel Mediated Calcium Transport" is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:0070588 ! calcium ion transmembrane transport [Term] id: GO:0015086 name: cadmium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf] synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0070574 ! cadmium ion transmembrane transport [Term] id: GO:0015087 name: cobalt ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:dgf] synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] xref: RHEA:28578 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0006824 ! cobalt ion transport [Term] id: GO:0015089 name: high-affinity copper ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1] synonym: "high affinity copper ion transmembrane transporter activity" EXACT [] synonym: "high affinity copper transporter activity" EXACT [] is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0015090 name: low-affinity ferric iron ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1] synonym: "low affinity iron ion transmembrane transporter activity" EXACT [] synonym: "low affinity iron transporter activity" EXACT [] is_a: GO:0015091 ! ferric iron transmembrane transporter activity [Term] id: GO:0015091 name: ferric iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732] comment: Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity. is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity [Term] id: GO:0015092 name: high-affinity ferric iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:ai, PMID:1447137] comment: https://github.com/geneontology/go-ontology/issues/14372 synonym: "high affinity ferric uptake transmembrane transporter activity" RELATED [] is_a: GO:0015091 ! ferric iron transmembrane transporter activity [Term] id: GO:0015093 name: ferrous iron transmembrane transporter activity namespace: molecular_function alt_id: GO:0015639 def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732] synonym: "ferrous iron uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1362417 "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix" xref: Reactome:R-HSA-442368 "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-5655760 "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol" xref: RHEA:28486 is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015094 name: lead ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015692 ! lead ion transport [Term] id: GO:0015095 name: magnesium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf] xref: Reactome:R-HSA-442661 "SLC41A1,2 transport Mg2+ from extracellular region to cytosol" xref: Reactome:R-HSA-5336453 "NIPAs transport Mg2+ from extracellular region to cytosol" xref: Reactome:R-HSA-5336454 "MMGT1 transports Mg2+ from cytosol to Golgi lumen" xref: Reactome:R-HSA-5336466 "MRS2 transports Mg2+ from cytosol to mitochondrial matrix" xref: Reactome:R-HSA-5339528 "TUSC3 transports Mg2+ from extracellular region to cytosol" xref: Reactome:R-HSA-5339538 "MAGT1 transports Mg2+ from extracellular region to cytosol" xref: RHEA:29827 is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:1903830 ! magnesium ion transmembrane transport [Term] id: GO:0015096 name: obsolete manganese resistance permease activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition. synonym: "manganese resistance permease activity" EXACT [] is_obsolete: true [Term] id: GO:0015097 name: mercury ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] xref: RHEA:32815 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0015694 ! mercury ion transport [Term] id: GO:0015098 name: molybdate ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732] synonym: "molybdate transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015689 ! molybdate ion transport [Term] id: GO:0015099 name: nickel cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other." [GOC:ai] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] xref: RHEA:29831 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0035444 ! nickel cation transmembrane transport [Term] id: GO:0015100 name: vanadium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0015676 ! vanadium ion transport [Term] id: GO:0015101 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" is_a: GO:0008324 ! cation transmembrane transporter activity relationship: part_of GO:0015695 ! organic cation transport [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015698 ! inorganic anion transport [Term] id: GO:0015104 name: antimonite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of antimonite from one side of a membrane to the other." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015699 ! antimonite transport [Term] id: GO:0015105 name: arsenite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arsenite from one side of a membrane to the other." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015700 ! arsenite transport [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015701 ! bicarbonate transport [Term] id: GO:0015107 name: chlorate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other." [GOC:curators] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015702 ! chlorate transport [Term] id: GO:0015108 name: chloride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] synonym: "chloride ion transmembrane transporter activity" EXACT [GOC:pr] xref: Reactome:R-HSA-5678822 "Defective CFTR does not transport Cl- from cytosol to extracellular region" xref: Reactome:R-HSA-5678863 "CFTR transports Cl- from cytosol to extracellular region" xref: Reactome:R-HSA-5678992 "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region" xref: RHEA:29823 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:1902476 ! chloride transmembrane transport [Term] id: GO:0015109 name: chromate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] xref: RHEA:32819 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015703 ! chromate transport [Term] id: GO:0015110 name: cyanate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015704 ! cyanate transport [Term] id: GO:0015111 name: iodide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] xref: Reactome:R-HSA-209910 "Iodide is taken up by thyroid epithelial cells" xref: Reactome:R-HSA-5627802 "SLC26A4 transports I- from cytosol to extracellular region" xref: Reactome:R-HSA-5627870 "SLC26A4 does not transport I- from cytosol to extracellular region" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015705 ! iodide transport [Term] id: GO:0015112 name: nitrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai] synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015706 ! nitrate transport [Term] id: GO:0015113 name: nitrite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai] synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015707 ! nitrite transport [Term] id: GO:0015114 name: phosphate ion transmembrane transporter activity namespace: molecular_function alt_id: GO:1901677 def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw] xref: RHEA:32823 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0035435 ! phosphate ion transmembrane transport created_by: pr creation_date: 2012-11-22T15:43:10Z [Term] id: GO:0015115 name: silicate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0015708 ! silicic acid import across plasma membrane [Term] id: GO:0015116 name: sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] synonym: "sulfate permease activity" RELATED [] synonym: "sulphate transporter activity" EXACT [] xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol" xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902358 ! sulfate transmembrane transport [Term] id: GO:0015117 name: thiosulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai] synonym: "thiosulfate permease activity" RELATED [] synonym: "thiosulphate transporter activity" EXACT [] xref: RHEA:32807 is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015709 ! thiosulfate transport [Term] id: GO:0015119 name: hexose phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015712 ! hexose phosphate transport [Term] id: GO:0015120 name: phosphoglycerate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015713 ! phosphoglycerate transmembrane transport [Term] id: GO:0015121 name: phosphoenolpyruvate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl] synonym: "phosphoenolpyruvate/phosphate translocator" EXACT [] synonym: "PPT" BROAD [PMID:10488230] is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0089721 ! phosphoenolpyruvate transmembrane transporter activity [Term] id: GO:0015123 name: acetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0035433 ! acetate transmembrane transport [Term] id: GO:0015124 name: allantoate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0015719 ! allantoate transport [Term] id: GO:0015125 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport ALB:(GCCA, TCCA) from extracellular region to cytosol" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0015721 ! bile acid and bile salt transport [Term] id: GO:0015126 name: canalicular bile acid transmembrane transporter activity namespace: molecular_function def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015125 ! bile acid transmembrane transporter activity relationship: part_of GO:0015722 ! canalicular bile acid transport [Term] id: GO:0015127 name: bilirubin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region" xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0015723 ! bilirubin transport [Term] id: GO:0015128 name: gluconate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0042879 ! aldonate transmembrane transporter activity relationship: part_of GO:0035429 ! gluconate transmembrane transport [Term] id: GO:0015129 name: lactate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] xref: Reactome:R-HSA-373867 "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-373875 "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0035873 ! lactate transmembrane transport [Term] id: GO:0015130 name: mevalonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0015728 ! mevalonate transport [Term] id: GO:0015131 name: oxaloacetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity relationship: part_of GO:1902356 ! oxaloacetate(2-) transmembrane transport [Term] id: GO:0015132 name: prostaglandin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] synonym: "prostaglandin/thromboxane transporter activity" BROAD [] xref: Reactome:R-HSA-5661188 "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol" xref: Reactome:R-HSA-879528 "SLCO2A1 transports PGT substrates from extracellular region to cytosol" is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0071714 ! icosanoid transmembrane transporter activity relationship: part_of GO:0015732 ! prostaglandin transport [Term] id: GO:0015133 name: uronic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity relationship: part_of GO:0015735 ! uronic acid transmembrane transport [Term] id: GO:0015134 name: hexuronate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015163 def: "Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "hexuronide transmembrane transporter activity" EXACT [] is_a: GO:0015133 ! uronic acid transmembrane transporter activity relationship: part_of GO:0015736 ! hexuronate transmembrane transport relationship: part_of GO:0015778 ! hexuronide transport [Term] id: GO:0015135 name: glucuronate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity relationship: part_of GO:0015738 ! glucuronate transmembrane transport [Term] id: GO:0015136 name: sialic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sialic acid from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015739 ! sialic acid transport [Term] id: GO:0015137 name: citrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai] synonym: "tricarboxylate transport protein" RELATED [] {comment="WIkipedia:Mitochondrial_carrier"} xref: Reactome:R-HSA-433104 "NACT co-transports trivalent citrate and a sodium ion" is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity relationship: part_of GO:0015746 ! citrate transport [Term] id: GO:0015138 name: fumarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity relationship: part_of GO:0015741 ! fumarate transport [Term] id: GO:0015139 name: alpha-ketoglutarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] synonym: "2-oxoglutarate transporter activity" EXACT [] xref: Reactome:R-HSA-372480 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0015742 ! alpha-ketoglutarate transport [Term] id: GO:0015140 name: malate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity relationship: part_of GO:0071423 ! malate transmembrane transport [Term] id: GO:0015141 name: succinate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity relationship: part_of GO:0071422 ! succinate transmembrane transport [Term] id: GO:0015142 name: tricarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:R-HSA-372449 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]" xref: Reactome:R-HSA-75849 "Transport of Citrate from Mitochondrial Matrix to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0035674 ! tricarboxylic acid transmembrane transport [Term] id: GO:0015143 name: urate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] synonym: "uric acid transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-2872497 "SLC17A3-2 transports cytosolic urate to extracellular region" xref: Reactome:R-HSA-561253 "SLC22A12 exchanges extracellular urate for cytosolic LACT" xref: Reactome:R-HSA-5625210 "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:1901702 ! salt transmembrane transporter activity relationship: part_of GO:0015747 ! urate transport [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function alt_id: GO:1901476 def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "carbohydrate transporter activity" RELATED [] synonym: "sugar transporter" NARROW [] xref: MIPS_funcat:20.01.03 is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0015145 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0051119 ! sugar transmembrane transporter activity relationship: part_of GO:0015749 ! monosaccharide transmembrane transport [Term] id: GO:0015146 name: pentose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms," [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015145 ! monosaccharide transmembrane transporter activity relationship: part_of GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015147 name: L-arabinose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015148 name: D-xylose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015146 ! pentose transmembrane transporter activity relationship: part_of GO:0015753 ! D-xylose transmembrane transport [Term] id: GO:0015149 name: hexose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity relationship: part_of GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015150 name: fucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015756 ! fucose transmembrane transport [Term] id: GO:0015151 name: alpha-glucoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] is_a: GO:0042947 ! glucoside transmembrane transporter activity relationship: part_of GO:0000017 ! alpha-glucoside transport [Term] id: GO:0015152 name: glucose-6-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015760 ! glucose-6-phosphate transport [Term] id: GO:0015153 name: rhamnose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015762 ! rhamnose transmembrane transport [Term] id: GO:0015154 name: disaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of disaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity relationship: part_of GO:0015766 ! disaccharide transport [Term] id: GO:0015155 name: lactose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019189 def: "Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "lactose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015767 ! lactose transport [Term] id: GO:0015156 name: melibiose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015769 ! melibiose transport [Term] id: GO:0015157 name: oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oligosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "endosomal oligosaccharide transporter" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity relationship: part_of GO:0015772 ! oligosaccharide transport [Term] id: GO:0015158 name: raffinose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "raffinose permease" RELATED [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity relationship: part_of GO:0015773 ! raffinose transport [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity relationship: part_of GO:0015774 ! polysaccharide transport [Term] id: GO:0015160 name: beta-glucan transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0015775 ! beta-glucan transport [Term] id: GO:0015161 name: capsular polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of capsular-polysaccharides from one side of a membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "capsule polysaccharide transporter activity" EXACT [] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0015776 ! capsular polysaccharide transport [Term] id: GO:0015164 name: glucuronoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glucuronide transporter activity" EXACT [] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015779 ! glucuronoside transport [Term] id: GO:0015165 name: pyrimidine nucleotide-sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport [Term] id: GO:0015166 name: polyol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732] synonym: "sugar/polyol channel activity" NARROW [] xref: Reactome:R-HSA-429571 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6" is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0015791 ! polyol transport [Term] id: GO:0015167 name: arabitol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "arabinitol transporter activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015792 ! arabinitol transmembrane transport [Term] id: GO:0015168 name: glycerol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015793 ! glycerol transport [Term] id: GO:0015169 name: glycerol-3-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015794 ! glycerol-3-phosphate transmembrane transport [Term] id: GO:0015170 name: propanediol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015799 ! propanediol transport [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015359 def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: MIPS_funcat:20.01.07 xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol" xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0003333 ! amino acid transmembrane transport [Term] id: GO:0015172 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "acidic amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015800 ! acidic amino acid transport [Term] id: GO:0015173 name: aromatic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aromatic amino acid transporter activity" BROAD [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015174 name: basic amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005286 alt_id: GO:0015326 def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "basic amino acid permease activity" EXACT [] synonym: "basic amino acid transporter activity" BROAD [] synonym: "cationic amino acid transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-8932851 "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8959781 "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:1990822 ! basic amino acid transmembrane transport [Term] id: GO:0015175 name: neutral amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "neutral amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015804 ! neutral amino acid transport [Term] id: GO:0015176 name: obsolete holin namespace: molecular_function def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "holin" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015179 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] id: GO:0015180 name: L-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "L-alanine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity relationship: part_of GO:0015808 ! L-alanine transport [Term] id: GO:0015181 name: arginine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005288 def: "Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "arginine permease activity" EXACT [] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-arginine transporter activity" NARROW [] xref: RHEA:32143 is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity relationship: part_of GO:1903826 ! arginine transmembrane transport [Term] id: GO:0015182 name: L-asparagine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "asparagine/glutamine permease activity" NARROW [] synonym: "L-asparagine transporter activity" BROAD [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0006867 ! asparagine transport [Term] id: GO:0015183 name: L-aspartate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-aspartate transporter activity" BROAD [] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity relationship: part_of GO:0070778 ! L-aspartate transmembrane transport [Term] id: GO:0015184 name: L-cystine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-cystine transporter activity" BROAD [] xref: Reactome:R-HSA-5340130 "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol" is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0015811 ! L-cystine transport [Term] id: GO:0015185 name: gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015812 ! gamma-aminobutyric acid transport [Term] id: GO:0015186 name: L-glutamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "asparagine/glutamine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0006868 ! glutamine transport [Term] id: GO:0015187 name: glycine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015816 ! glycine transport [Term] id: GO:0015188 name: L-isoleucine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-isoleucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0015189 name: L-lysine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005293 def: "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-lysine permease" RELATED [] synonym: "lysine permease activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:1903401 ! L-lysine transmembrane transport [Term] id: GO:0015190 name: L-leucine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-leucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0015191 name: L-methionine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-methionine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0043865 ! methionine transmembrane transporter activity [Term] id: GO:0015192 name: L-phenylalanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-phenylalanine permease activity" EXACT [] synonym: "L-phenylalanine transporter activity" BROAD [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015823 ! phenylalanine transport [Term] id: GO:0015193 name: L-proline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005296 def: "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "L-proline permease activity" RELATED [] synonym: "L-proline transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: Reactome:R-HSA-8870354 "SLC36A4 transports extracellular L-Pro to the cytosol" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0035524 ! proline transmembrane transport [Term] id: GO:0015194 name: L-serine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015511 alt_id: GO:1905361 def: "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-serine permease activity" RELATED [] synonym: "L-serine transporter activity" BROAD [] synonym: "serine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] xref: Reactome:R-HSA-8932980 "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022889 ! serine transmembrane transporter activity relationship: part_of GO:0015825 ! L-serine transport [Term] id: GO:0015195 name: L-threonine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015512 def: "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-threonine permease activity" RELATED [] synonym: "L-threonine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015826 ! threonine transport [Term] id: GO:0015196 name: L-tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0005299 def: "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-tryptophan permease activity" EXACT [] synonym: "L-tryptophan transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] xref: Reactome:R-HSA-8870352 "SLC36A4 transports L-Trp from extracellular region to cytosol" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015827 ! tryptophan transport [Term] id: GO:0015199 name: amino-acid betaine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid." [GOC:ai] synonym: "betaine transmembrane transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0015838 ! amino-acid betaine transport [Term] id: GO:0015200 name: methylammonium transmembrane transporter activity namespace: molecular_function def: "Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other." [GOC:ai] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity relationship: part_of GO:0072489 ! methylammonium transmembrane transport [Term] id: GO:0015203 name: polyamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other." [GOC:ai] synonym: "amine/amide/polyamine channel activity" RELATED [] xref: MIPS_funcat:20.01.11 is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1902047 ! polyamine transmembrane transport [Term] id: GO:0015204 name: urea transmembrane transporter activity namespace: molecular_function alt_id: GO:0015287 def: "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732] synonym: "urea transporter activity" BROAD [] xref: Reactome:R-HSA-444126 "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively" xref: RHEA:32799 is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0071918 ! urea transmembrane transport [Term] id: GO:0015205 name: nucleobase transmembrane transporter activity namespace: molecular_function alt_id: GO:0015392 def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015851 ! nucleobase transport [Term] id: GO:0015207 name: adenine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] xref: Reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane" xref: Reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane" is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity relationship: part_of GO:0015853 ! adenine transport [Term] id: GO:0015208 name: guanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity relationship: part_of GO:1903716 ! guanine transmembrane transport [Term] id: GO:0015209 name: cytosine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity relationship: part_of GO:0015856 ! cytosine transport [Term] id: GO:0015210 name: uracil transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" RELATED [] is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity relationship: part_of GO:1903791 ! uracil transmembrane transport [Term] id: GO:0015211 name: purine nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] is_a: GO:0005337 ! nucleoside transmembrane transporter activity relationship: part_of GO:0015860 ! purine nucleoside transmembrane transport [Term] id: GO:0015212 name: cytidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity relationship: part_of GO:0015861 ! cytidine transport [Term] id: GO:0015213 name: uridine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" NARROW [] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity relationship: part_of GO:0015862 ! uridine transport [Term] id: GO:0015214 name: pyrimidine nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] is_a: GO:0005337 ! nucleoside transmembrane transporter activity relationship: part_of GO:0072531 ! pyrimidine-containing compound transmembrane transport [Term] id: GO:0015215 name: nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732] xref: MIPS_funcat:20.01.17 is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity relationship: part_of GO:1901679 ! nucleotide transmembrane transport [Term] id: GO:0015216 name: purine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity relationship: part_of GO:0015865 ! purine nucleotide transport [Term] id: GO:0015217 name: ADP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity relationship: part_of GO:0015866 ! ADP transport [Term] id: GO:0015218 name: pyrimidine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity relationship: part_of GO:0006864 ! pyrimidine nucleotide transport [Term] id: GO:0015219 name: obsolete protein-DNA complex transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai] comment: This term was obsoleted because there is no experimental evidence that this function exists. See https://github.com/geneontology/go-ontology/issues/17005 synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0015220 name: choline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005306 def: "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "choline permease activity" EXACT [] xref: Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol" xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity relationship: part_of GO:0015871 ! choline transport [Term] id: GO:0015221 name: lipopolysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "LPS transmembrane transporter activity" EXACT [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015920 ! lipopolysaccharide transport [Term] id: GO:0015223 name: obsolete vitamin or cofactor transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "vitamin or cofactor transporter activity" EXACT [] synonym: "vitamin/cofactor transporter activity" EXACT [] is_obsolete: true consider: GO:0051184 consider: GO:0090482 [Term] id: GO:0015224 name: biopterin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732] synonym: "biopterin transporter activity" RELATED [] is_a: GO:0051185 ! coenzyme transmembrane transporter activity relationship: part_of GO:0015877 ! biopterin transport [Term] id: GO:0015225 name: biotin transmembrane transporter activity namespace: molecular_function alt_id: GO:1901603 def: "Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "biotin transporter activity" RELATED [] synonym: "vitamin B7 transporter activity" RELATED [] synonym: "vitamin H transporter activity" RELATED [] xref: RHEA:28458 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015878 ! biotin transport created_by: al creation_date: 2012-11-08T14:18:56Z [Term] id: GO:0015226 name: carnitine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] synonym: "vitamin Bt transporter activity" EXACT [] xref: Reactome:R-HSA-164967 "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space" xref: Reactome:R-HSA-165026 "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol" xref: Reactome:R-HSA-549297 "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5625674 "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol" is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:1902603 ! carnitine transmembrane transport [Term] id: GO:0015227 name: acyl carnitine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] synonym: "acylcarnitine transporter activity" BROAD [] xref: Reactome:R-HSA-200424 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane" is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity relationship: part_of GO:1902616 ! acyl carnitine transmembrane transport [Term] id: GO:0015228 name: coenzyme A transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] synonym: "coenzyme A transporter activity" BROAD [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity relationship: part_of GO:0035349 ! coenzyme A transmembrane transport [Term] id: GO:0015229 name: L-ascorbic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ISBN:0198506732] synonym: "L-ascorbate transporter activity" EXACT [] synonym: "vitamin C transporter activity" EXACT [] xref: Reactome:R-HSA-198870 "SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015882 ! L-ascorbic acid transmembrane transport [Term] id: GO:0015230 name: FAD transmembrane transporter activity namespace: molecular_function alt_id: GO:0005472 def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] synonym: "FAD carrier activity" RELATED [] synonym: "FAD transporter activity" BROAD [] synonym: "flavin adenine dinucleotide carrier activity" RELATED [] synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "flavin-adenine dinucleotide carrier activity" RELATED [] synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity relationship: part_of GO:0035350 ! FAD transmembrane transport [Term] id: GO:0015231 name: 5-formyltetrahydrofolate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other." [GOC:ai] synonym: "5-formyltetrahydrofolate transporter activity" EXACT [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0015885 ! 5-formyltetrahydrofolate transport [Term] id: GO:0015232 name: heme transporter activity namespace: molecular_function def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai] synonym: "haem transporter activity" EXACT [] xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix" xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport" xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix" xref: Reactome:R-HSA-917870 "SLC46A1 transports FeHM from extracellular region to cytosol" xref: Reactome:R-HSA-917892 "FLVCR transports heme from cytosol to extracellular region" xref: Reactome:R-HSA-917979 "ABCG2 dimer transports heme from cytosol to extracellular region" is_a: GO:0051184 ! cofactor transmembrane transporter activity relationship: part_of GO:0015886 ! heme transport [Term] id: GO:0015233 name: pantothenate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate transporter activity" BROAD [GOC:mah] synonym: "vitamin B5 transmembrane transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015887 ! pantothenate transmembrane transport [Term] id: GO:0015234 name: thiamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015402 alt_id: GO:0015403 def: "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "thiamin permease activity" EXACT [] synonym: "thiamin transmembrane transporter activity" EXACT [] synonym: "thiamin uptake transporter activity" RELATED [] synonym: "thiamine permease activity" EXACT [] synonym: "thiamine uptake transmembrane transporter activity" RELATED [] synonym: "vitamin B1 transporter activity" EXACT [] xref: Reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol" is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0071934 ! thiamine transmembrane transport [Term] id: GO:0015240 name: amiloride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732] synonym: "amiloride transporter activity" RELATED [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0015898 ! amiloride transport [Term] id: GO:0015243 name: cycloheximide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] synonym: "cycloheximide transporter activity" RELATED [] is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0015901 ! cycloheximide transport [Term] id: GO:0015244 name: fluconazole transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] synonym: "fluconazole transporter activity" RELATED [] is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity relationship: part_of GO:0015903 ! fluconazole transport [Term] id: GO:0015245 name: fatty acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015246 def: "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] synonym: "fatty acid transporter activity" RELATED [] synonym: "fatty acyl transporter activity" EXACT [] synonym: "fatty-acyl group transporter activity" BROAD [] synonym: "peroxisomal fatty acyl transporter" NARROW [] xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol" xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0015908 ! fatty acid transport [Term] id: GO:0015247 name: aminophospholipid flippase activity namespace: molecular_function def: "Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:pg] synonym: "aminophospholipid transmembrane transporter activity" RELATED [] synonym: "aminophospholipid transporter activity" RELATED [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140327 ! flippase activity relationship: part_of GO:0140331 ! aminophospholipid translocation [Term] id: GO:0015248 name: sterol transporter activity namespace: molecular_function def: "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] xref: Reactome:R-HSA-265783 "ABCG5:ABCG8 transports sterols from cytosol to extracellular region" xref: Reactome:R-HSA-5250531 "ARV1 transports CHOL from ER membrane to plasma membrane" xref: Reactome:R-HSA-5679101 "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region" xref: Reactome:R-HSA-5679145 "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region" xref: Reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane" xref: Reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane" is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0015918 ! sterol transport [Term] id: GO:0015250 name: water channel activity namespace: molecular_function def: "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] synonym: "aquaporin" NARROW [] xref: Reactome:R-HSA-432010 "Aquaporin-1 passively transports water into cell" xref: Reactome:R-HSA-432054 "Aquaporin-1 passively transports water out of cell" xref: Reactome:R-HSA-432065 "p-S256-Aquaporin-2 passively transports water into cell" xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell" xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell" xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells" xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells" is_a: GO:0005372 ! water transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015251 name: ammonium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity is_a: GO:0008519 ! ammonium transmembrane transporter activity [Term] id: GO:0015252 name: proton channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "hydrogen ion channel activity" EXACT [] is_a: GO:0005261 ! cation channel activity is_a: GO:0015078 ! proton transmembrane transporter activity [Term] id: GO:0015253 name: obsolete sugar/polyol channel activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. synonym: "sugar/polyol channel activity" EXACT [] is_obsolete: true consider: GO:0015166 consider: GO:0051119 [Term] id: GO:0015254 name: glycerol channel activity namespace: molecular_function def: "Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell" xref: Reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell" xref: Reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells" xref: Reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells" is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015255 name: propanediol channel activity namespace: molecular_function def: "Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] is_a: GO:0015170 ! propanediol transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015256 name: obsolete monocarboxylate channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "monocarboxylate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015257 name: obsolete organic anion channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "organic anion channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015258 name: obsolete gluconate channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "gluconate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015259 name: obsolete glutamate channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "glutamate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015260 name: obsolete isethionate channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "isethionate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015261 name: obsolete lactate channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "lactate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015262 name: obsolete taurine channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "taurine channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015263 name: obsolete amine/amide/polyamine channel activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents three molecular functions. synonym: "amine/amide/polyamine channel activity" EXACT [] is_obsolete: true consider: GO:0005275 consider: GO:0015203 consider: GO:0042887 [Term] id: GO:0015264 name: methylammonium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport, GOC:pr] is_a: GO:0015200 ! methylammonium transmembrane transporter activity is_a: GO:0015251 ! ammonium channel activity [Term] id: GO:0015265 name: urea channel activity namespace: molecular_function def: "Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: Reactome:R-HSA-507873 "Aquaporins passively transport urea out of cells" xref: Reactome:R-HSA-507875 "Aquaporins passively transport urea into cells" is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015267 name: channel activity namespace: molecular_function alt_id: GO:0015249 alt_id: GO:0015268 alt_id: GO:0022838 def: "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] synonym: "alpha-type channel activity" RELATED [] synonym: "channel-forming toxin activity" RELATED [] synonym: "channel/pore class transporter activity" EXACT [] synonym: "nonselective channel activity" EXACT [] synonym: "pore activity" BROAD [] synonym: "pore class transporter activity" RELATED [] synonym: "substrate-specific channel activity" RELATED [] xref: MIPS_funcat:20.03.01 xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol" xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix" xref: TC:1 is_a: GO:0022803 ! passive transmembrane transporter activity [Term] id: GO:0015269 name: calcium-activated potassium channel activity namespace: molecular_function def: "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] is_a: GO:0005227 ! calcium activated cation channel activity is_a: GO:0005267 ! potassium channel activity [Term] id: GO:0015271 name: outward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0015272 name: ATP-activated inward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] xref: Reactome:R-HSA-5683209 "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)." is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015274 name: organellar voltage-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "organellar voltage gated chloride channel activity" EXACT [] synonym: "organellar voltage-dependent chloride channel activity" EXACT [] is_a: GO:0005247 ! voltage-gated chloride channel activity [Term] id: GO:0015275 name: stretch-activated, cation-selective, calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] is_a: GO:0005262 ! calcium channel activity is_a: GO:0140135 ! mechanosensitive cation channel activity [Term] id: GO:0015276 name: ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart] xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors" xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors" xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable nicotinic acetylcholine receptors" xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors" xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors" is_a: GO:0005216 ! ion channel activity is_a: GO:0022834 ! ligand-gated channel activity [Term] id: GO:0015277 name: kainate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0005267 ! potassium channel activity is_a: GO:0005272 ! sodium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0015278 name: calcium-release channel activity namespace: molecular_function alt_id: GO:0005218 def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0099604 ! ligand-gated calcium channel activity relationship: part_of GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0015279 name: store-operated calcium channel activity namespace: molecular_function def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710] xref: Reactome:R-HSA-434798 "CRAC translocates calcium from the extracellular region to the cytosol" is_a: GO:0005262 ! calcium channel activity [Term] id: GO:0015280 name: ligand-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "acid-sensing ion channel activity" NARROW [GOC:fj] synonym: "amiloride-sensitive sodium channel activity" NARROW [GOC:fj] synonym: "ASIC activity" NARROW [GOC:fj] synonym: "epithelial sodium channel" NARROW [GOC:fj] xref: Reactome:R-HSA-2672334 "SCNN channels transport extracellular Na+ to cytosol" is_a: GO:0005272 ! sodium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0015282 name: obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it describes a gene product rather than a function. synonym: "NADPH oxidase-associated cytochrome b558 hydrogen channel activity" EXACT [] synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT [] is_obsolete: true [Term] id: GO:0015283 name: obsolete apoptogenic cytochrome c release channel activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a gene product. synonym: "apoptogenic cytochrome c release channel activity" EXACT [] synonym: "Bcl-2" NARROW [] is_obsolete: true [Term] id: GO:0015284 name: fructose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015288 name: porin activity namespace: molecular_function def: "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] synonym: "outer membrane exporter porin" NARROW [] synonym: "porin" EXACT [] xref: Wikipedia:Porin_(protein) is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0015289 name: obsolete pore-forming toxin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820] comment: This term was made obsolete because it represents a class of gene products. synonym: "pore-forming toxin activity" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0009405 consider: GO:0046930 consider: GO:0046931 consider: GO:0090729 [Term] id: GO:0015291 name: secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0015290 alt_id: GO:0015353 alt_id: GO:0015404 alt_id: GO:0015570 def: "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820] synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "ion-gradient-driven energizer activity" NARROW [] synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: Reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix" xref: TC:2.A is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015292 name: uniporter activity namespace: molecular_function def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "facilitated diffusion carrier" EXACT [] synonym: "single-species transporter activity" EXACT [] synonym: "uniport" RELATED [] xref: MIPS_funcat:20.03.03 is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015293 name: symporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "cotransporter activity" BROAD [] synonym: "porter activity" BROAD [] synonym: "symport" RELATED [] xref: MIPS_funcat:20.03.05 is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015294 name: solute:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] is_a: GO:0015293 ! symporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0015295 name: solute:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] synonym: "solute:hydrogen symporter activity" EXACT [] xref: MIPS_funcat:20.03.05.01 is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015296 name: anion:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015297 name: antiporter activity namespace: molecular_function alt_id: GO:0015300 alt_id: GO:0099516 def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "antiport" RELATED [] synonym: "countertransporter activity" EXACT [] synonym: "exchange transporter activity" EXACT [] synonym: "exchanger" BROAD [] synonym: "ion antiporter activity" NARROW [] synonym: "porter" BROAD [] synonym: "solute:solute antiporter activity" EXACT [] synonym: "solute:solute exchange" RELATED [] xref: MIPS_funcat:20.03.07 xref: Reactome:R-HSA-2730692 "CLCN4/5/6 exchange Cl- for H+" xref: Reactome:R-HSA-2730959 "CLCN7:OSTM1 exchanges Cl- for H+" xref: Reactome:R-HSA-2731002 "CLCN3 exchanges Cl- for H+" is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015298 name: solute:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015297 ! antiporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015299 name: solute:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:hydrogen antiporter activity" EXACT [] xref: MIPS_funcat:20.03.07.01 is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0015301 name: anion:anion antiporter activity namespace: molecular_function alt_id: GO:0015380 alt_id: GO:0015384 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] synonym: "anion exchanger activity" EXACT [] synonym: "bicarbonate:chloride antiporter" NARROW [] xref: Reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids" is_a: GO:0140323 ! solute:anion antiporter activity [Term] id: GO:0015303 name: obsolete galactose, glucose uniporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6] comment: This term was made obsolete because it represents two molecular functions. synonym: "galactose, glucose uniporter activity" EXACT [] is_obsolete: true consider: GO:0015304 consider: GO:0050782 [Term] id: GO:0015304 name: glucose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" NARROW [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015305 name: obsolete lactose, galactose:proton symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9] comment: This term was made obsolete because it represents two molecular functions. synonym: "lactose, galactose:hydrogen symporter activity" EXACT [] synonym: "lactose, galactose:proton symporter activity" EXACT [] synonym: "lactose,galactose:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015517 consider: GO:0015528 [Term] id: GO:0015306 name: sialate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] synonym: "cation/sialate symporter activity" EXACT [] synonym: "cation:sialate symporter activity" EXACT [] synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015307 name: obsolete drug:proton antiporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport. synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "drug:hydrogen antiporter activity" EXACT [] xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+" xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" is_obsolete: true [Term] id: GO:0015308 name: amiloride:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] synonym: "amiloride:hydrogen antiporter activity" EXACT [] is_a: GO:0015240 ! amiloride transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0015309 name: cycloheximide:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] synonym: "cycloheximide:hydrogen antiporter activity" EXACT [] is_a: GO:0015243 ! cycloheximide transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015310 name: benomyl:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] synonym: "benomyl:hydrogen antiporter activity" EXACT [] is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:1901479 ! benomyl transmembrane transporter activity [Term] id: GO:0015311 name: monoamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] synonym: "monoamine:hydrogen antiporter activity" EXACT [] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015312 name: polyamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] synonym: "polyamine:hydrogen antiporter activity" EXACT [] is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015313 name: fluconazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] synonym: "fluconazole:hydrogen antiporter activity" EXACT [] is_a: GO:0015244 ! fluconazole transmembrane transporter activity is_a: GO:0045119 ! azole:proton antiporter activity [Term] id: GO:0015314 name: aminotriazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] synonym: "aminotriazole:hydrogen antiporter activity" EXACT [] is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0045119 ! azole:proton antiporter activity is_a: GO:1901478 ! aminotriazole transmembrane transporter activity [Term] id: GO:0015315 name: organophosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0140323 ! solute:anion antiporter activity [Term] id: GO:0015316 name: obsolete nitrite/nitrate porter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "nitrite/nitrate porter activity" EXACT [] is_obsolete: true consider: GO:0015112 consider: GO:0015113 consider: GO:0015291 [Term] id: GO:0015317 name: phosphate:proton symporter activity namespace: molecular_function alt_id: GO:0015320 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] comment: Merge phosphate ion carrier activity and phosphate:proton symporter activity, https://github.com/geneontology/go-ontology/issues/14221 synonym: "phosphate ion carrier activity" EXACT [] synonym: "phosphate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015318 name: inorganic molecular entity transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] comment: Renamed term see https://github.com/geneontology/go-ontology/issues/14372 subset: gocheck_do_not_annotate synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] synonym: "inorganic uptake permease activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015319 name: sodium:inorganic phosphate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] is_a: GO:0005315 ! inorganic phosphate transmembrane transporter activity is_a: GO:0005436 ! sodium:phosphate symporter activity [Term] id: GO:0015321 name: sodium-dependent phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] xref: Reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+" xref: Reactome:R-HSA-427656 "SLC34A1,2 cotransports HPO4(2-), 3Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport" xref: Reactome:R-HSA-5625123 "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5651685 "Defective SLC34A1 does not cotransport Pi, 3Na+" xref: Reactome:R-HSA-5651697 "Defective SLC34A2 does not cotransport Pi, 3Na+" xref: Reactome:R-HSA-5651971 "Defective SLC34A3 does not cotransport Pi, 2Na+" xref: Reactome:R-HSA-5687585 "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol" is_a: GO:0015114 ! phosphate ion transmembrane transporter activity relationship: part_of GO:0044341 ! sodium-dependent phosphate transport [Term] id: GO:0015322 name: secondary active oligopeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "oligopeptide porter activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015323 name: obsolete type V protein secretor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type V protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015324 name: peptide-acetyl-CoA secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "peptide-acetyl-CoA transporter activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015325 name: acetyl-CoA:CoA antiporter activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] is_a: GO:0008521 ! acetyl-CoA transmembrane transporter activity is_a: GO:0015228 ! coenzyme A transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity [Term] id: GO:0015327 name: cystine:glutamate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015328 ! cystine secondary active transmembrane transporter activity [Term] id: GO:0015328 name: cystine secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "cystine porter activity" RELATED [] synonym: "cystinosin" NARROW [] synonym: "lysosomal cystine transporter" NARROW [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity [Term] id: GO:0015330 name: high-affinity glutamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity glutamine permease activity" RELATED [] synonym: "high affinity glutamine transmembrane transporter activity" EXACT [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015186 ! L-glutamine transmembrane transporter activity [Term] id: GO:0015331 name: obsolete asparagine/glutamine permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "asparagine/glutamine permease activity" EXACT [] is_obsolete: true consider: GO:0015182 consider: GO:0015186 consider: GO:0022857 [Term] id: GO:0015332 name: obsolete leucine/valine/isoleucine permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "leucine/valine/isoleucine permease activity" EXACT [] is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0022857 [Term] id: GO:0015333 name: peptide:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] synonym: "peptide:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-427998 "Proton-coupled di- and tri-peptide cotransport" xref: Reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport" is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity [Term] id: GO:0015334 name: high-affinity oligopeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] synonym: "high affinity oligopeptide transporter activity" EXACT [] synonym: "high-affinity oligopeptide transporter activity" RELATED [] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015335 name: obsolete heavy metal ion:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "heavy metal ion:hydrogen symporter activity" EXACT [] synonym: "heavy metal ion:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015336 name: obsolete high affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "high affinity metal ion uptake transporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015337 name: obsolete low affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "low affinity metal ion uptake transporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015339 name: obsolete cobalt, zinc uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1] comment: This term was made obsolete because it represents more than one molecular function. synonym: "cobalt, zinc uptake permease activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015087 [Term] id: GO:0015340 name: obsolete zinc, cadmium uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, cadmium uptake permease activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015086 [Term] id: GO:0015341 name: zinc efflux active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] synonym: "zinc efflux permease activity" BROAD [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity is_a: GO:0022883 ! zinc efflux transmembrane transporter activity [Term] id: GO:0015342 name: obsolete zinc, iron permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, iron permease activity" EXACT [] is_obsolete: true consider: GO:0005381 consider: GO:0005385 [Term] id: GO:0015343 name: siderophore transmembrane transporter activity namespace: molecular_function alt_id: GO:0015236 alt_id: GO:0015237 alt_id: GO:0042927 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] synonym: "iron-siderophore transporter activity" EXACT [] synonym: "siderochrome transporter activity" NARROW [] synonym: "siderochrome-iron transporter activity" NARROW [] synonym: "siderophore transporter activity" RELATED [] synonym: "siderophore-iron transmembrane transporter activity" RELATED [] synonym: "siderophore-iron transporter activity" RELATED [] xref: MIPS_funcat:20.01.01.01.01.01 xref: Reactome:R-HSA-1222597 "Loaded mycobactin gets imported" is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0044718 ! siderophore transmembrane transport [Term] id: GO:0015344 name: siderophore uptake transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED [] synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED [] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015345 name: ferric enterobactin:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] synonym: "ferric enterobactin:hydrogen symporter activity" EXACT [] synonym: "ferric-enterobactin:proton symporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015346 name: ferric triacetylfusarinine C:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity relationship: part_of GO:0015686 ! ferric triacetylfusarinine C import into cell [Term] id: GO:0015347 name: sodium-independent organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] xref: Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates" xref: Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity" xref: Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity" xref: Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015348 name: obsolete prostaglandin/thromboxane transporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "prostaglandin/thromboxane transporter activity" EXACT [] is_obsolete: true consider: GO:0008028 consider: GO:0015132 [Term] id: GO:0015349 name: thyroid hormone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] xref: Reactome:R-HSA-5661195 "Defective SLCO1B1 does not transport T3,T4 from extracellular region to cytosol" xref: Reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol" xref: Reactome:R-HSA-9631987 "SLCO1B1 transports T3,T4 from extracellular region to cytosol" is_a: GO:0015291 ! secondary active transmembrane transporter activity relationship: part_of GO:0070327 ! thyroid hormone transport [Term] id: GO:0015350 name: methotrexate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] synonym: "methotrexate transporter activity" RELATED [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0051958 ! methotrexate transport [Term] id: GO:0015351 name: bilirubin secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "bilirubin porter activity" RELATED [] synonym: "bilitranslocase" NARROW [] is_a: GO:0015127 ! bilirubin transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015352 name: obsolete secondary active sterol transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] comment: This term was obsoleted because there is no evidence that this function exists. synonym: "sterol porter activity" RELATED [] is_obsolete: true [Term] id: GO:0015355 name: secondary active monocarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] synonym: "monocarboxylate porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015356 name: obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" EXACT [] is_obsolete: true consider: GO:0015129 consider: GO:0015130 consider: GO:0015562 consider: GO:0050833 [Term] id: GO:0015358 name: obsolete amino acid/choline transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "amino acid/choline transmembrane transporter activity" EXACT [] is_obsolete: true consider: GO:0015171 consider: GO:0015220 [Term] id: GO:0015360 name: acetate:proton symporter activity namespace: molecular_function alt_id: GO:0015357 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] synonym: "acetate:hydrogen symporter activity" EXACT [] synonym: "hydrogen:acetate symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0043893 ! acetate:cation symporter activity [Term] id: GO:0015361 name: low-affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT [] xref: Reactome:R-HSA-433131 "NaDC1 co-transports dicarboxylic acids and a sodium ion" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015362 name: high-affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT [] xref: Reactome:R-HSA-433101 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015363 name: obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" EXACT [] is_obsolete: true consider: GO:0005310 consider: GO:0015138 consider: GO:0015140 consider: GO:0015141 consider: GO:0015297 [Term] id: GO:0015364 name: dicarboxylate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015366 name: malate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] synonym: "L-malic acid permease" RELATED [GOC:vw] synonym: "L-malic acid:proton symporter activity" RELATED [GOC:vw] synonym: "malate permease" RELATED [GOC:vw] synonym: "malate:hydrogen symporter activity" EXACT [] is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015367 name: oxoglutarate:malate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] synonym: "2-oxoglutarate/malate carrier protein" EXACT [Wikipedia:Mitochondrial_carrier] xref: Reactome:R-HSA-198440 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]" xref: Reactome:R-HSA-376851 "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015368 name: calcium:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] xref: Reactome:R-HSA-425822 "K+-independent Li+/Ca2+ exchanger transport" is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015369 name: calcium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] synonym: "calcium:hydrogen antiporter activity" EXACT [] xref: Reactome:R-HSA-8949687 "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" xref: RHEA:29671 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0015368 ! calcium:cation antiporter activity is_a: GO:0051139 ! metal ion:proton antiporter activity [Term] id: GO:0015370 name: solute:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: MIPS_funcat:20.03.05.03 xref: Reactome:R-HSA-8876283 "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015371 name: galactose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015372 name: obsolete glutamate/aspartate:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glutamate/aspartate:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0005313 consider: GO:0015183 [Term] id: GO:0015373 name: anion:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] synonym: "monovalent anion:sodium symporter activity" EXACT [] is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015374 name: neutral, basic amino acid:sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED [] is_a: GO:0005283 ! amino acid:sodium symporter activity relationship: part_of GO:0006821 ! chloride transport [Term] id: GO:0015375 name: glycine:sodium symporter activity namespace: molecular_function alt_id: GO:0015656 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] xref: Reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5660840 "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol" is_a: GO:0005295 ! neutral amino acid:sodium symporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015187 ! glycine transmembrane transporter activity [Term] id: GO:0015376 name: obsolete betaine/GABA:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "betaine/GABA:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005332 consider: GO:0015185 consider: GO:0015199 consider: GO:0015370 [Term] id: GO:0015377 name: cation:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] synonym: "cation:chloride cotransporter activity" BROAD [] is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015378 name: sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] xref: Reactome:R-HSA-426130 "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5623705 "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol" is_a: GO:0015373 ! anion:sodium symporter activity is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015379 name: potassium:chloride symporter activity namespace: molecular_function alt_id: GO:0022820 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] synonym: "potassium ion symporter activity" BROAD [] xref: Reactome:R-HSA-426155 "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" xref: Reactome:R-HSA-5623806 "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region" is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015381 name: high-affinity sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity sulfate permease activity" RELATED [] synonym: "high affinity sulfate transmembrane transporter activity" EXACT [] synonym: "high affinity sulphate permease activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity [Term] id: GO:0015382 name: sodium:sulfate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] synonym: "sodium:sulfate cotransporter activity" BROAD [] synonym: "sodium:sulphate symporter activity" EXACT [] xref: Reactome:R-HSA-433099 "NaS2 co-transports sulphate and two sodium ions" xref: Reactome:R-HSA-433114 "NaS1 co-transports sulphate and a sodium ion" is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015373 ! anion:sodium symporter activity [Term] id: GO:0015383 name: sulfate:bicarbonate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] synonym: "sulphate:bicarbonate antiporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015385 name: sodium:proton antiporter activity namespace: molecular_function alt_id: GO:0015502 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] synonym: "pH-dependent sodium:proton antiporter activity" NARROW [] synonym: "sodium/hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] xref: Reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+" xref: Reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+" xref: Reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane" xref: Reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane" xref: Reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)" xref: Reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)" xref: Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane" xref: Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane" xref: RHEA:29251 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0051139 ! metal ion:proton antiporter activity [Term] id: GO:0015386 name: potassium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] synonym: "potassium:hydrogen antiporter activity" EXACT [] xref: RHEA:29467 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0015387 name: potassium:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] synonym: "potassium:hydrogen symporter activity" EXACT [] xref: RHEA:28490 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015389 name: pyrimidine- and adenine-specific:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity is_a: GO:0005415 ! nucleoside:sodium symporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015390 name: purine-specific nucleoside:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015391 name: nucleobase:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] is_a: GO:0015205 ! nucleobase transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015393 name: obsolete uracil/uridine permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "uracil/uridine permease activity" EXACT [] is_obsolete: true consider: GO:0015210 consider: GO:0015213 consider: GO:0022857 [Term] id: GO:0015394 name: uridine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] synonym: "nucleoside (uridine) permease activity" RELATED [] synonym: "uridine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015213 ! uridine transmembrane transporter activity is_a: GO:0015506 ! nucleoside:proton symporter activity [Term] id: GO:0015395 name: nucleoside transmembrane transporter activity, down a concentration gradient namespace: molecular_function alt_id: GO:0015396 alt_id: GO:0015397 def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW [] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW [] synonym: "equilibrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015398 name: high-affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity secondary active ammonium transmembrane transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015399 name: primary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] synonym: "primary active transporter" RELATED [] xref: TC:3 is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015400 name: low-affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] synonym: "low affinity secondary active ammonium transmembrane transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015401 name: urea:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] synonym: "urea active transmembrane transporter activity" EXACT [] is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015406 name: obsolete ABC-type uptake permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type uptake permease activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015407 name: ATPase-coupled monosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17] synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17] synonym: "ATP-dependent monosaccharide transmembrane transporter activity" EXACT [] synonym: "monosaccharide ABC transporter" NARROW [] synonym: "monosaccharide-importing ATPase activity" NARROW [] synonym: "monosaccharide-transporting ATPase activity" EXACT [] xref: EC:3.6.3.17 xref: MetaCyc:3.6.3.17-RXN xref: RHEA:29900 is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0015408 name: ATPase-coupled ferric iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:7.2.2.7] synonym: "ABC-type Fe3+ transporter" EXACT [] synonym: "Fe3+-transporting ATPase activity" EXACT [EC:7.2.2.7] synonym: "ferric ABC transporter" NARROW [] synonym: "ferric transporting ATPase activity" EXACT [] synonym: "ferric-transporting ATPase activity" EXACT [] xref: EC:7.2.2.7 xref: MetaCyc:3.6.3.30-RXN xref: RHEA:12332 is_a: GO:0015091 ! ferric iron transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015410 name: manganese transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:7.2.2.5] synonym: "ABC-type Mn(2+) transporter" EXACT [EC:7.2.2.5] synonym: "ATP-dependent manganese transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled manganese transmembrane transporter activity" RELATED [] synonym: "manganese ABC transporter" NARROW [] synonym: "manganese-transporting ATPase activity" EXACT [EC:7.2.2.5] xref: EC:7.2.2.5 xref: MetaCyc:3.6.3.35-RXN xref: Reactome:R-HSA-5692462 "ATP13A1 transports Mn2+ from cytosol to ER lumen" xref: RHEA:17365 is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015411 name: ATPase-coupled taurine transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:7.6.2.7] synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:7.6.2.7] synonym: "ATP-dependent taurine transporter activity" EXACT [] synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT [] synonym: "taurine ABC transporter" NARROW [] synonym: "taurine-transporting ATPase activity" EXACT [] xref: EC:7.6.2.7 xref: MetaCyc:3.6.3.36-RXN xref: RHEA:14614 is_a: GO:0005368 ! taurine transmembrane transporter activity is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015412 name: ATPase-coupled molybdate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:7.3.2.5] synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:7.3.2.5] synonym: "molybdate ABC transporter" NARROW [] synonym: "molybdate porter activity" EXACT [] synonym: "molybdate transmembrane-transporting ATPase activity" RELATED [] synonym: "molybdate transporting ATPase activity" EXACT [] synonym: "molybdate-transporting ATPase activity" EXACT [EC:7.3.2.5] xref: EC:7.3.2.5 xref: MetaCyc:3.6.3.29-RXN xref: RHEA:22020 is_a: GO:0015098 ! molybdate ion transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0015413 name: ATPase-coupled nickel transmembrane transporter activity namespace: molecular_function alt_id: GO:0102016 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:7.2.2.11] synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:7.2.2.11] synonym: "ATP-dependent nickel transmembrane transporter activity" EXACT [] synonym: "nickel ABC transporter" NARROW [] synonym: "nickel ABC transporter activity" EXACT [] synonym: "nickel porter activity" EXACT [] synonym: "nickel transporting ATPase activity" EXACT [] synonym: "nickel-transporting ATPase activity" EXACT [] xref: EC:7.2.2.11 xref: MetaCyc:3.6.3.24-RXN xref: MetaCyc:ABC-20-RXN xref: RHEA:15557 is_a: GO:0015099 ! nickel cation transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015414 name: ATPase-coupled nitrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:7.3.2.4] synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:7.3.2.4] synonym: "nitrate ABC transporter" NARROW [] synonym: "nitrate transmembrane-transporting ATPase activity" RELATED [] synonym: "nitrate transporting ATPase activity" EXACT [] synonym: "nitrate-transporting ATPase activity" EXACT [EC:7.3.2.4] xref: EC:7.3.2.4 xref: MetaCyc:3.6.3.26-RXN xref: RHEA:13181 is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0015415 name: ATPase-coupled phosphate ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:7.3.2.1] synonym: "ABC phosphate transporter activity" NARROW [EC:7.3.2.1] synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:7.3.2.1] synonym: "phosphate ABC transporter" NARROW [] synonym: "phosphate ion transmembrane-transporting ATPase activity" RELATED [] synonym: "phosphate porter activity" EXACT [] synonym: "phosphate transporting ATPase activity" EXACT [] synonym: "phosphate-transporting ATPase activity" EXACT [EC:7.3.2.1] xref: EC:7.3.2.1 xref: RHEA:24440 is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0015416 name: ATPase-coupled organic phosphonate transmembrane transporter activity namespace: molecular_function alt_id: GO:0102017 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:7.3.2.2] synonym: "alkylphosphonate ABC transporter activity" NARROW [] synonym: "alkylphosphonate transmembrane-transporting ATPase activity" NARROW [] synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [] synonym: "ATPase-coupled alkylphosphonate transmembrane transporter activity" NARROW [] synonym: "organic phosphonate transmembrane-transporting ATPase activity" RELATED [] synonym: "phosphonate ABC transporter" NARROW [] synonym: "phosphonate transporting ATPase activity" EXACT [] synonym: "phosphonate-transporting ATPase activity" EXACT [] xref: EC:7.3.2.2 xref: MetaCyc:3.6.3.28-RXN xref: MetaCyc:ABC-23-RXN xref: RHEA:18065 is_a: GO:0015604 ! organic phosphonate transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0015417 name: ATPase-coupled polyamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:7.6.2.11] synonym: "ABC-type polyamine transporter" EXACT [EC:7.6.2.11] synonym: "ATP-dependent polyamine transmembrane transporter activity" EXACT [] synonym: "polyamine ABC transporter" NARROW [EC:7.6.2.11] synonym: "polyamine porter activity" EXACT [] synonym: "polyamine-importing ATPase activity" NARROW [] synonym: "polyamine-transporting ATPase activity" EXACT [EC:7.6.2.11] xref: EC:7.6.2.11 xref: MetaCyc:3.6.3.31-RXN is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0015418 name: ATPase-coupled quaternary ammonium compound transmembrane transporting activity namespace: molecular_function alt_id: GO:0102908 def: "Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in)." [EC:7.6.2.9, GOC:pz] synonym: "ATP-dependent quaternary-ammonium compound transmembrane transporting activity" EXACT [] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "quarternary amine transporter activity" BROAD [] synonym: "quaternary amine uptake transporter activity" EXACT [] synonym: "quaternary-amine-transporting ATPase activity" EXACT [] synonym: "quaternary-ammonium-compound ABC transporter" RELATED [] synonym: "quaternary-ammonium-compound-transporting ATPase activity" EXACT [] xref: EC:7.6.2.9 xref: MetaCyc:3.6.3.32-RXN xref: MetaCyc:RXN-8638 xref: RHEA:11036 is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015419 name: ATPase-coupled sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:7.3.2.3] synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:7.3.2.3] synonym: "sulfate ABC transporter" NARROW [] synonym: "sulfate transmembrane-transporting ATPase activity" RELATED [] synonym: "sulfate transporting ATPase activity" EXACT [] synonym: "sulfate-transporting ATPase activity" EXACT [EC:7.3.2.3] synonym: "sulfate/thiosulfate porter activity" EXACT [] synonym: "sulphate transporting ATPase activity" EXACT [] synonym: "sulphate-transporting ATPase activity" EXACT [] xref: EC:3.6.3.25 xref: MetaCyc:3.6.3.25-RXN xref: RHEA:10192 is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0015420 name: ATPase-coupled vitamin B12 transmembrane transporter activity namespace: molecular_function alt_id: GO:0015235 alt_id: GO:0102023 def: "Catalysis of the reaction: ATP(4-) + cob(I)alamin + H2O <=> ADP(3-) + hydrogenphosphate + cob(I)alamin + H+. Cobalamin is also known as vitamin B12." [EC:7.6.2.8, GOC:pz] synonym: "ATP-dependent cobalamin transmembrane transporter activity" EXACT [] synonym: "ATP-dependent vitamin B12 transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled cobalamin transmembrane transporter activity" EXACT [] synonym: "cobalamin ABC transporter" NARROW [] synonym: "cobalamin porter activity" BROAD [] synonym: "cobalamin transporter activity" BROAD [] synonym: "cobalamin-transporting ATPase activity" EXACT [] synonym: "vitamin B12 ABC transporter activity" EXACT [] synonym: "vitamin B12 porter activity" BROAD [] synonym: "vitamin B12 transporter activity" BROAD [] synonym: "vitamin B12-transporting ATPase activity" BROAD [] xref: EC:7.6.2.8 xref: MetaCyc:3.6.3.33-RXN xref: MetaCyc:ABC-5-RXN xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome" xref: Reactome:R-HSA-3000238 "LMBRD1 transports lysosomal Cbl to cytosol" xref: Reactome:R-HSA-3095901 "ABCC1 transports cytosolic Cbl to extracellular region" xref: Reactome:R-HSA-3315437 "Defective LMBRD1 does not transport lysosomal Cbl to cytosol" xref: RHEA:17873 xref: RHEA:32831 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015889 ! cobalamin transport [Term] id: GO:0015421 name: ATPase-coupled oligopeptide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:7.4.2.6] synonym: "ABC-type oligopeptide transporter" EXACT [EC:7.4.2.6] synonym: "ATP-dependent oligopeptide transmembrane transporter activity" EXACT [] synonym: "oligopeptide ABC transporter" NARROW [] synonym: "oligopeptide permease activity" RELATED [EC:7.4.2.6] synonym: "oligopeptide-transporting ATPase activity" EXACT [EC:7.4.2.6] xref: EC:7.4.2.6 xref: MetaCyc:3.6.3.23-RXN xref: Reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen" is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015422 name: ATPase-coupled oligosaccharide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015609 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:7.5.2.2] synonym: "ABC-type oligosaccharide transporter" EXACT [EC:7.5.2.2] synonym: "ATP-dependent oligosaccharide transmembrane transporter activity" EXACT [] synonym: "maltooligosaccharide porter activity" NARROW [] synonym: "maltooligosaccharide-importing ATPase activity" NARROW [] synonym: "oligosaccharide ABC transporter" NARROW [] synonym: "oligosaccharide-transporting ATPase activity" EXACT [EC:7.5.2.2] xref: EC:7.5.2.2 xref: MetaCyc:3.6.3.18-RXN is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0015423 name: ATPase-coupled maltose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:7.5.2.1] synonym: "ABC-type maltose transporter" EXACT [EC:7.5.2.1] synonym: "ATP-dependent maltose transmembrane transporter activity" EXACT [] synonym: "maltose ABC transporter" NARROW [] synonym: "maltose-transporting ATPase activity" EXACT [EC:7.5.2.1] xref: EC:7.5.2.1 xref: MetaCyc:3.6.3.19-RXN xref: RHEA:22132 is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015422 ! ATPase-coupled oligosaccharide transmembrane transporter activity relationship: part_of GO:1904981 ! maltose transmembrane transport [Term] id: GO:0015424 name: ATPase-coupled amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0032518 alt_id: GO:0032520 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] synonym: "amino acid ABC transporter" NARROW [] synonym: "amino acid-exporting ATPase activity" RELATED [] synonym: "amino acid-importing ATPase activity" RELATED [] synonym: "amino acid-transporting ATPase activity" EXACT [] synonym: "ATP-dependent amino acid transmembrane transporter activity" EXACT [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity [Term] id: GO:0015425 name: ATPase-coupled nonpolar-amino acid transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:7.4.2.2] synonym: "ATP-dependent nonpolar-amino acid transporter activity" EXACT [] synonym: "leucine/isoleucine/valine porter activity" RELATED [] synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] synonym: "nonpolar-amino acid ABC transporter" EXACT [] synonym: "nonpolar-amino acid-transporting ATPase activity" EXACT [] synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] xref: EC:7.4.2.2 xref: MetaCyc:3.6.3.22-RXN xref: TC:3.A.1.4.1 is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity [Term] id: GO:0015426 name: ATPase-coupled polar amino acid-transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:7.4.2.1] synonym: "ATP-dependent polar amino acid-transporter activity" EXACT [] synonym: "cystine/diaminopimelate porter activity" RELATED [] synonym: "glutamate/aspartate porter activity" RELATED [] synonym: "histidine permease activity" NARROW [EC:7.4.2.1] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "polar amino acid uptake transporter activity" EXACT [] synonym: "polar amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino acid ABC transporter" NARROW [] synonym: "polar-amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino acid-transporting ATPase activity" EXACT [] synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:7.4.2.1] xref: EC:7.4.2.1 xref: MetaCyc:3.6.3.21-RXN is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity [Term] id: GO:0015427 name: obsolete ABC-type efflux porter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type efflux porter activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015428 name: obsolete type I protein secretor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type I protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015429 name: obsolete peroxisomal fatty acyl transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains both component and function information. synonym: "peroxisomal fatty acyl transporter" EXACT [] is_obsolete: true [Term] id: GO:0015430 name: ATPase-coupled glycerol-3-phosphate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015610 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:7.6.2.10] synonym: "ABC-type glycerol 3-phosphate transporter" EXACT [EC:7.6.2.10] synonym: "glycerol phosphate-importing ATPase activity" NARROW [] synonym: "glycerol-3-phosphate ABC transporter" NARROW [EC:7.6.2.10] synonym: "glycerol-3-phosphate-transporting ATPase" EXACT [EC:7.6.2.10] synonym: "glycerol-phosphate porter activity" NARROW [] xref: EC:7.6.2.10 xref: MetaCyc:3.6.3.20-RXN xref: RHEA:21669 is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015431 name: ATPase-coupled glutathione S-conjugate transmembrane transporter activity namespace: molecular_function alt_id: GO:0071997 def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517] synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] synonym: "conjugate transporter activity" BROAD [] synonym: "glutathione S-conjugate-exporting ATPase activity" NARROW [] synonym: "glutathione S-conjugate-transporting ATPase activity" RELATED [EC:7.6.2.3] synonym: "GS-X pump" EXACT [] synonym: "MRP1/GS-X pump" EXACT [] xref: EC:7.6.2.3 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity created_by: midori creation_date: 2010-10-25T02:32:02Z [Term] id: GO:0015432 name: ATPase-coupled bile acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2] synonym: "ATP-dependent bile acid transmembrane transporter activity" EXACT [] synonym: "bile acid porter activity" NARROW [] synonym: "bile acid-exporting ATPase activity" BROAD [] xref: Reactome:R-HSA-193362 "ABCB11 transports bile salts from cytosol to extracellular region" xref: Reactome:R-HSA-194153 "Transport (efflux) of bile salts by ABCC3 (MRP3)" xref: Reactome:R-HSA-5678517 "Defective ABCB11 does not transport bile salts from cytosol to extracellular region" is_a: GO:0015125 ! bile acid transmembrane transporter activity is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity [Term] id: GO:0015433 name: ATPase-coupled peptide antigen transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] synonym: "ATP-dependent peptide antigen transmembrane transporter activity" EXACT [] synonym: "major histocompatibility peptide transporter activity" EXACT [] synonym: "peptide antigen ABC transporter" NARROW [] synonym: "peptide antigen transporter activity" BROAD [] synonym: "peptide antigen-transporting ATPase activity" EXACT [] xref: Reactome:R-HSA-1236949 "Translocation of antigenic peptides back to phagosomes via TAP" xref: Reactome:R-HSA-983144 "Transport of Antigen peptide in to ER" is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity [Term] id: GO:0015434 name: ATPase-coupled cadmium transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:7.2.2.2] synonym: "ATP-dependent cadmium transmembrane transporter activity" EXACT [] synonym: "cadmium ABC transporter" NARROW [] synonym: "cadmium-transporting ATPase activity" EXACT [EC:7.2.2.2] xref: EC:7.2.2.2 xref: MetaCyc:3.6.3.46-RXN is_a: GO:0015086 ! cadmium ion transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015435 name: obsolete ABC-type efflux permease activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type efflux permease activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015436 name: ATPase-coupled capsular-polysaccharide transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:7.6.2.12] synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:7.6.2.12] synonym: "ATP-dependent capsular-polysaccharide transporter activity" EXACT [] synonym: "capsular-polysaccharide ABC transporter" NARROW [] synonym: "capsular-polysaccharide-transporting ATPase activity" EXACT [] xref: EC:7.6.2.12 xref: MetaCyc:3.6.3.38-RXN is_a: GO:0015161 ! capsular polysaccharide transmembrane transporter activity is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0015437 name: lipopolysaccharide floppase activity namespace: molecular_function def: "Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [EC:7.5.2.5] synonym: "ATP-dependent intramembrane lipopolysaccharide transporter activity" EXACT [] synonym: "ATPase-coupled intramembrane lipopolysaccharide transporter activity" BROAD [] synonym: "lipopolysaccharide ABC transporter" NARROW [] synonym: "lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "lipopolysaccharide-transporting ATPase activity" EXACT [] synonym: "LPS-transporting ATPase activity" EXACT [] xref: EC:7.5.2.5 is_a: GO:0140328 ! floppase activity relationship: part_of GO:0015920 ! lipopolysaccharide transport [Term] id: GO:0015438 name: ATPase-coupled teichoic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015162 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:7.5.2.4, PMID:7565096] synonym: "ABC-type teichoic-acid transporter" EXACT [EC:7.5.2.4] synonym: "ATP-dependent teichoic acid transmembrane transporter activity" EXACT [] synonym: "teichoic acid transmembrane transporter activity" BROAD [] synonym: "teichoic-acid ABC transporter" NARROW [] synonym: "teichoic-acid-transporting ATPase activity" EXACT [EC:7.5.2.4] xref: EC:7.5.2.4 xref: MetaCyc:3.6.3.40-RXN is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015777 ! teichoic acid transport [Term] id: GO:0015439 name: ATPase-coupled heme transmembrane transporter activity namespace: molecular_function alt_id: GO:0103115 def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:7.6.2.5] synonym: "ATP-dependent heme transmembrane transporter activity" EXACT [] synonym: "haem-transporting ATPase activity" EXACT [] synonym: "heme ABC transporter" NARROW [] synonym: "heme-transporting ATPase activity" EXACT [] synonym: "protoheme IX ABC transporter activity" RELATED [] xref: EC:7.6.2.5 xref: MetaCyc:3.6.3.41-RXN xref: MetaCyc:TRANS-RXN0-162 xref: RHEA:19261 is_a: GO:0015232 ! heme transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity relationship: part_of GO:0035351 ! heme transmembrane transport [Term] id: GO:0015440 name: ATPase-coupled peptide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:7.4.2.5] synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:7.4.2.5] synonym: "ATP-dependent peptide transmembrane transporter activity" EXACT [] synonym: "peptide ABC transporter" NARROW [] synonym: "peptide-transporting ATPase activity" EXACT [] xref: EC:7.4.2.5 xref: MetaCyc:3.6.3.43-RXN is_a: GO:0033220 ! ATPase-coupled amide-transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0015833 ! peptide transport [Term] id: GO:0015441 name: ATPase-coupled beta-glucan transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:7.5.2.3] synonym: "ABC-type beta-glucan transporter" EXACT [EC:7.5.2.3] synonym: "ATP-dependent beta-glucan transporter activity" EXACT [] synonym: "beta-glucan ABC transporter" NARROW [] synonym: "beta-glucan-transporting ATPase activity" EXACT [EC:7.5.2.3] xref: EC:7.5.2.3 xref: MetaCyc:3.6.3.42-RXN xref: RHEA:18453 is_a: GO:0015160 ! beta-glucan transmembrane transporter activity is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0015442 name: obsolete hydrogen-/sodium-translocating ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-] comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification. synonym: "hydrogen-/sodium-translocating ATPase activity" EXACT [] synonym: "proton-/sodium-translocating ATPase activity" EXACT [] is_obsolete: true consider: GO:0008553 consider: GO:0008554 [Term] id: GO:0015443 name: obsolete sodium-transporting two-sector ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "sodium-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046932 consider: GO:0046962 [Term] id: GO:0015444 name: magnesium transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in)." [EC:7.2.2.14] synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:7.2.2.14] synonym: "magnesium importing ATPase activity" EXACT [] synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:7.2.2.14] synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:7.2.2.14] synonym: "Mg2+-importing ATPase activity" EXACT [EC:7.2.2.14] xref: EC:7.2.2.14 xref: MetaCyc:3.6.3.2-RXN xref: RHEA:10260 is_a: GO:0015095 ! magnesium ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015445 name: silver transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out)." [EC:7.2.2.15] synonym: "Ag+-exporting ATPase activity" EXACT [EC:7.2.2.15] synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:7.2.2.15] synonym: "silver exporting ATPase activity" EXACT [] synonym: "silver-exporting ATPase activity" RELATED [] xref: EC:7.2.2.15 xref: MetaCyc:3.6.3.53-RXN xref: RHEA:14733 is_a: GO:0015080 ! silver ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0015446 name: ATPase-coupled arsenite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16] synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance efflux pump" EXACT [] synonym: "arsenite ABC transporter" NARROW [] synonym: "arsenite transporting ATPase activity" EXACT [] synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenite-transmembrane transporting ATPase activity" RELATED [] synonym: "arsenite-transporting ATPase activity" EXACT [EC:7.3.2.7, GOC:vw] synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:7.3.2.7] xref: EC:7.3.2.7 xref: MetaCyc:3.6.3.16-RXN xref: RHEA:11348 is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:1901683 ! arsenate ion transmembrane transporter activity relationship: part_of GO:0015700 ! arsenite transport [Term] id: GO:0015447 name: obsolete type II protein secretor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type II protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015448 name: obsolete type III protein (virulence-related) secretor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type III protein (virulence-related) secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015449 name: obsolete type IV protein (DNA-protein) secretor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type IV protein (DNA-protein) secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015450 name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity namespace: molecular_function def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] synonym: "protein translocase activity" EXACT [] xref: EC:7.4.2.3 xref: EC:7.4.2.4 xref: Reactome:R-HSA-1222523 "SodB gets secreted" is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015451 name: decarboxylation-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] synonym: "decarboxylation-driven transporter" RELATED [] xref: EC:7.2.4.1 xref: EC:7.2.4.2 xref: EC:7.2.4.3 xref: EC:7.2.4.4 xref: EC:7.2.4.5 xref: TC:3.B is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015452 name: methyl transfer-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] synonym: "Methyltransfer-driven transporters" EXACT [] xref: TC:3.C is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015453 name: oxidoreduction-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] synonym: "Oxidoreduction-driven transporters" EXACT [] xref: TC:3.D is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015454 name: light-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] synonym: "Light absorption-driven transporters" EXACT [] synonym: "light-driven pumps" EXACT [] xref: TC:3.E is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015459 name: potassium channel regulator activity namespace: molecular_function def: "Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification)." [GOC:dos, GOC:mah] synonym: "potassium channel gating activity" EXACT [] is_a: GO:0099106 ! ion channel regulator activity relationship: regulates GO:0005267 ! potassium channel activity [Term] id: GO:0015461 name: obsolete endosomal oligosaccharide transporter namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "endosomal oligosaccharide transporter" EXACT [] is_obsolete: true consider: GO:0005768 consider: GO:0015157 [Term] id: GO:0015462 name: ATPase-coupled protein transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [GOC:jl] synonym: "pilin/fimbrilin exporter activity" NARROW [] synonym: "protein ABC transporter" NARROW [] synonym: "protein-transmembrane transporting ATPase activity" RELATED [] synonym: "protein-transporting ATPase activity" EXACT [] xref: EC:7.4.2.5 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity relationship: has_part GO:0042166 ! acetylcholine binding relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0015465 name: obsolete lysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products. synonym: "lysin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015466 name: obsolete autolysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma] comment: This term was made obsolete because it represents a class of gene products. synonym: "autolysin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015467 name: G-protein activated inward rectifier potassium channel activity namespace: molecular_function alt_id: GO:0015273 def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] xref: Reactome:R-HSA-1013020 "Activation of GIRK/Kir3 Channels" is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015468 name: obsolete colicin namespace: molecular_function def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "colicin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005198 consider: GO:0009405 consider: GO:0019835 consider: GO:0046930 consider: GO:0046931 consider: GO:0090729 [Term] id: GO:0015469 name: obsolete channel-forming toxin activity namespace: molecular_function def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai] comment: This term was made obsolete because it represents a class of gene products. synonym: "channel-forming toxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0015267 consider: GO:0035915 consider: GO:0046930 consider: GO:0090729 [Term] id: GO:0015470 name: obsolete bacteriocin activity namespace: molecular_function def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "bacteriocin activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0019835 [Term] id: GO:0015471 name: nucleoside-specific channel forming porin activity namespace: molecular_function def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015472 name: obsolete fimbrium-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046] comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function. synonym: "fimbrium-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0009297 consider: GO:0030674 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0015473 name: fimbrial usher porin activity namespace: molecular_function def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] is_a: GO:0015288 ! porin activity [Term] id: GO:0015474 name: autotransporter activity namespace: molecular_function def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] is_a: GO:0015288 ! porin activity [Term] id: GO:0015475 name: adhesin autotransporter activity namespace: molecular_function def: "Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015476 name: hemaglutinin autotransporter activity namespace: molecular_function def: "Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015477 name: obsolete receptor porin activity namespace: molecular_function def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-] comment: This term was made obsolete because it combines two functions that are not linked. synonym: "receptor porin activity" EXACT [] is_obsolete: true [Term] id: GO:0015478 name: oligosaccharide transporting porin activity namespace: molecular_function def: "Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "raffinose porin" NARROW [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015479 name: obsolete outer membrane exporter porin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "outer membrane exporter porin" EXACT [] is_obsolete: true consider: GO:0009279 consider: GO:0015288 [Term] id: GO:0015480 name: obsolete secretin (sensu Bacteria) namespace: molecular_function def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "secretin (sensu Bacteria)" EXACT [] is_obsolete: true consider: GO:0008320 consider: GO:0045203 [Term] id: GO:0015481 name: maltose transporting porin activity namespace: molecular_function def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "maltoporin" EXACT [] xref: Wikipedia:Maltoporin is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015482 name: obsolete voltage-gated anion channel porin activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity. synonym: "voltage-dependent anion channel porin activity" EXACT [] synonym: "voltage-gated anion channel porin activity" EXACT [] is_obsolete: true [Term] id: GO:0015483 name: long-chain fatty acid transporting porin activity namespace: molecular_function def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015484 name: obsolete hemolysin activity namespace: molecular_function def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemolysin activity" EXACT [] is_obsolete: true consider: GO:0019836 [Term] id: GO:0015485 name: cholesterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732] is_a: GO:0032934 ! sterol binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0015486 name: glycoside-pentoside-hexuronide:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] is_a: GO:0005402 ! carbohydrate:cation symporter activity [Term] id: GO:0015487 name: melibiose:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] synonym: "melibiose permease activity" RELATED [] synonym: "melibiose:monovalent cation symporter activity" EXACT [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015156 ! melibiose transmembrane transporter activity [Term] id: GO:0015488 name: glucuronide:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] synonym: "glucuronide:monovalent cation symporter activity" EXACT [] synonym: "glucuronoside permease activity" RELATED [] is_a: GO:0015164 ! glucuronoside transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0015489 name: putrescine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity relationship: part_of GO:0015847 ! putrescine transport [Term] id: GO:0015491 name: cation:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0015492 name: phenylalanine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] synonym: "phenylalanine:hydrogen symporter activity" EXACT [] is_a: GO:0015494 ! aromatic amino acid:proton symporter activity [Term] id: GO:0015493 name: lysine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] synonym: "lysine:hydrogen symporter activity" EXACT [] is_a: GO:0005280 ! amino acid:proton symporter activity [Term] id: GO:0015494 name: aromatic amino acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] synonym: "aromatic amino acid:hydrogen symporter activity" EXACT [] is_a: GO:0005280 ! amino acid:proton symporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity [Term] id: GO:0015495 name: gamma-aminobutyric acid:proton symporter activity namespace: molecular_function alt_id: GO:0005331 alt_id: GO:0015329 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutanoate:proton symporter activity" EXACT [] synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutyrate:proton symporter activity" EXACT [] synonym: "GABA:hydrogen symporter activity" EXACT [] synonym: "GABA:proton symporter activity" EXACT [] synonym: "gamma-aminobutyric acid permease activity" EXACT [] synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-428625 "Vesicular inhibitory amino acid transport" is_a: GO:0005280 ! amino acid:proton symporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015496 name: putrescine:ornithine antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] synonym: "putrescine-ornithine antiporter activity" EXACT [] synonym: "putrescine/ornithine antiporter activity" EXACT [] synonym: "putrescine:hydrogen symporter activity" EXACT [] is_a: GO:0000064 ! L-ornithine transmembrane transporter activity is_a: GO:0015489 ! putrescine transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:0140323 ! solute:anion antiporter activity [Term] id: GO:0015498 name: pantothenate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity relationship: part_of GO:0098719 ! sodium ion import across plasma membrane [Term] id: GO:0015499 name: formate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015659 def: "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] synonym: "formate uptake permease activity" EXACT [] synonym: "formate uptake transmembrane transporter activity" RELATED [] xref: RHEA:29679 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0015724 ! formate transport [Term] id: GO:0015500 name: obsolete threonine/serine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "threonine/serine:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0015194 consider: GO:0015195 [Term] id: GO:0015501 name: glutamate:sodium symporter activity namespace: molecular_function alt_id: GO:0008027 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] synonym: "sodium/excitatory glutamate cotransporter activity" BROAD [] synonym: "sodium/excitatory glutamate symporter activity" EXACT [] xref: RHEA:29031 is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015503 name: glutathione-regulated potassium exporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015504 name: cytosine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] synonym: "cytosine permease activity" RELATED [] synonym: "cytosine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015209 ! cytosine transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015505 name: uracil:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] synonym: "uracil permease activity" RELATED [] is_a: GO:0015210 ! uracil transmembrane transporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015506 name: nucleoside:proton symporter activity namespace: molecular_function alt_id: GO:0015536 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] synonym: "nucleoside permease activity" RELATED [] synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] synonym: "nucleoside:hydrogen symporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015507 name: obsolete hydroxy/aromatic amino acid permease activity namespace: molecular_function def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "hydroxy/aromatic amino acid permease activity" EXACT [] is_obsolete: true consider: GO:0015171 consider: GO:0015173 [Term] id: GO:0015513 name: high-affinity secondary active nitrite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite uptake permease activity" EXACT [] is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015514 name: nitrite efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite extrusion permease activity" EXACT [] is_a: GO:0015113 ! nitrite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015515 name: citrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity [Term] id: GO:0015516 name: tartrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015554 ! tartrate transmembrane transporter activity [Term] id: GO:0015517 name: galactose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] synonym: "galactose:hydrogen symporter activity" EXACT [] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0009679 ! hexose:proton symporter activity [Term] id: GO:0015518 name: arabinose:proton symporter activity namespace: molecular_function alt_id: GO:0015523 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] synonym: "arabinose efflux permease activity" BROAD [] synonym: "arabinose efflux transmembrane transporter activity" BROAD [] synonym: "arabinose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015519 name: D-xylose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] synonym: "D-xylose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015148 ! D-xylose transmembrane transporter activity [Term] id: GO:0015520 name: tetracycline:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] synonym: "tetracyclin:proton antiporter activity" EXACT [] synonym: "tetracycline:hydrogen antiporter activity" EXACT [] is_a: GO:0008493 ! tetracycline transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015521 name: obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" EXACT [] synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT [] synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT [] is_obsolete: true consider: GO:0015545 consider: GO:0015546 consider: GO:0045119 [Term] id: GO:0015522 name: obsolete hydrophobic uncoupler:proton antiporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] comment: The reason for obsoletion is that this term represented a specific protein in TCDB, 2.A.1.2.9, which actually is a sugar transporter that seems to also function as a multidrug efflux protein. synonym: "hydrophobic uncoupler:hydrogen antiporter activity" EXACT [] is_obsolete: true [Term] id: GO:0015524 name: obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15] comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function. synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" EXACT [] synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT [] is_obsolete: true consider: GO:0015147 consider: GO:0015299 consider: GO:0051119 [Term] id: GO:0015525 name: obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" EXACT [] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT [] is_obsolete: true consider: GO:0015547 consider: GO:0015548 consider: GO:0015549 [Term] id: GO:0015526 name: hexose-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0015527 name: glycerol-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0140323 ! solute:anion antiporter activity [Term] id: GO:0015528 name: lactose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] synonym: "lactose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0015529 name: raffinose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] synonym: "raffinose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015158 ! raffinose transmembrane transporter activity [Term] id: GO:0015530 name: shikimate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0015733 ! shikimate transmembrane transport [Term] id: GO:0015531 name: citrate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] synonym: "citrate:hydrogen symporter activity" EXACT [] xref: RHEA:32123 is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity [Term] id: GO:0015532 name: alpha-ketoglutarate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] synonym: "2-oxoglutarate:proton symporter activity" EXACT [] synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT [] is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015533 name: shikimate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] synonym: "shikimate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0015530 ! shikimate transmembrane transporter activity [Term] id: GO:0015534 name: obsolete proline/glycine/betaine:hydrogen/sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" EXACT [] synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT [] is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015294 consider: GO:0015295 consider: GO:0015370 [Term] id: GO:0015535 name: fucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] synonym: "fucose:hydrogen symporter activity" EXACT [] xref: RHEA:29023 is_a: GO:0009679 ! hexose:proton symporter activity is_a: GO:0015150 ! fucose transmembrane transporter activity [Term] id: GO:0015537 name: xanthosine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] synonym: "xanthosine permease activity" RELATED [] synonym: "xanthosine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015506 ! nucleoside:proton symporter activity is_a: GO:0015553 ! xanthosine transmembrane transporter activity [Term] id: GO:0015538 name: sialic acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] synonym: "sialic acid permease activity" RELATED [] synonym: "sialic acid:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol" xref: Reactome:R-HSA-5624239 "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol" is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015539 name: hexuronate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] synonym: "hexuronate porter activity" RELATED [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015134 ! hexuronate transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015540 name: 3-hydroxyphenyl propionate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] synonym: "3-hydroxyphenyl propionate:hydrogen ion symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity [Term] id: GO:0015541 name: secondary active cyanate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyanate from one side of a membrane to the other." [TC:2.A.1.17.1] synonym: "cyanate porter activity" RELATED [] is_a: GO:0015110 ! cyanate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0015543 name: obsolete lactose/glucose efflux transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2] comment: This term was made obsolete because it represents two molecular functions. synonym: "lactose/glucose efflux transporter activity" EXACT [] is_obsolete: true consider: GO:0015155 [Term] id: GO:0015544 name: phenyl propionate uniporter activity namespace: molecular_function def: "Enables the transfer of phenyl propionate from one side of a membrane to the other." [GOC:mtg_transport, TC:2.A.1.27.1] synonym: "phenyl propionate permease activity" RELATED [] is_a: GO:0015292 ! uniporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0015552 ! propionate transmembrane transporter activity [Term] id: GO:0015545 name: bicyclomycin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:091191028X] synonym: "bicyclomycin transporter activity" RELATED [] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015905 ! bicyclomycin transmembrane transport [Term] id: GO:0015546 name: sulfathiazole transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group." [GOC:curators] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] synonym: "sulphathiazole transporter activity" EXACT [] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902599 ! sulfathiazole transmembrane transport [Term] id: GO:0015547 name: nalidixic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] synonym: "nalidixic acid transporter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0015896 ! nalidixic acid transport [Term] id: GO:0015548 name: organomercurial transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "organomercurial transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015897 ! organomercurial transport [Term] id: GO:0015549 name: carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators] synonym: "carbonyl cyanide m-chlorophenylhydrazone transporter activity" RELATED [] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] synonym: "CCCP transporter activity" EXACT [] is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0015902 ! carbonyl cyanide m-chlorophenylhydrazone transport [Term] id: GO:0015550 name: galacturonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity relationship: part_of GO:0015737 ! galacturonate transmembrane transport [Term] id: GO:0015551 name: 3-hydroxyphenyl propanoate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other." [GOC:ai] synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0015731 ! 3-hydroxyphenyl propanoate transport [Term] id: GO:0015552 name: propionate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] is_a: GO:0015636 ! short-chain fatty acid transmembrane transporter activity relationship: part_of GO:0015730 ! propanoate transport [Term] id: GO:0015553 name: xanthosine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity relationship: part_of GO:0015863 ! xanthosine transport [Term] id: GO:0015554 name: tartrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] is_a: GO:1901702 ! salt transmembrane transporter activity [Term] id: GO:0015556 name: C4-dicarboxylate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other." [GOC:krc] xref: MIPS_funcat:20.01.03.03 is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015558 name: secondary active p-aminobenzoyl-glutamate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015569 def: "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] synonym: "p-aminobenzoyl-glutamate transmembrane transporter activity" NARROW [] synonym: "p-aminobenzoyl-glutamate transporter activity" RELATED [] synonym: "p-aminobenzoyl-glutamate uptake permease activity" RELATED [] synonym: "p-aminobenzoyl-glutamate uptake transmembrane transporter activity" RELATED [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity is_a: GO:0071916 ! dipeptide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015560 name: obsolete L-idonate/D-gluconate:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "L-idonate/D-gluconate:hydrogen symporter activity" EXACT [] synonym: "L-idonate/D-gluconate:proton symporter" EXACT [] is_obsolete: true consider: GO:0015128 consider: GO:0015295 consider: GO:0015568 [Term] id: GO:0015561 name: rhamnose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1] synonym: "rhamnose:hydrogen symporter activity" EXACT [] is_a: GO:0009679 ! hexose:proton symporter activity is_a: GO:0015153 ! rhamnose transmembrane transporter activity [Term] id: GO:0015562 name: efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "efflux permease activity" EXACT [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015565 name: threonine efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "threonine efflux permease activity" EXACT [] synonym: "threonine export protein" RELATED [] synonym: "threonine export transporter activity" EXACT [] is_a: GO:0015195 ! L-threonine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015566 name: acriflavine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015555 def: "Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842] synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb] synonym: "acriflavin transporter activity" RELATED [GOC:dph, GOC:tb] synonym: "acriflavine transporter activity" RELATED [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901702 ! salt transmembrane transporter activity relationship: part_of GO:0015894 ! acriflavine transport [Term] id: GO:0015567 name: alkane transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015895 ! alkane transport [Term] id: GO:0015568 name: L-idonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0042879 ! aldonate transmembrane transporter activity relationship: part_of GO:0015726 ! L-idonate transmembrane transport [Term] id: GO:0015571 name: N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015590 def: "Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine permease activity" EXACT [] is_a: GO:0019196 ! galactosamine transmembrane transporter activity relationship: part_of GO:0015763 ! N-acetylgalactosamine transport [Term] id: GO:0015572 name: N-acetylglucosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015580 def: "Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] synonym: "N-Acetyl-D-glucosamine permease" RELATED [] synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylglucosamine permease activity" RELATED [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015573 name: beta-glucoside transmembrane transporter activity namespace: molecular_function alt_id: GO:0015582 def: "Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] synonym: "beta-glucoside permease activity" EXACT [] is_a: GO:0042947 ! glucoside transmembrane transporter activity relationship: part_of GO:0015759 ! beta-glucoside transport [Term] id: GO:0015574 name: trehalose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015584 def: "Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "trehalose permease activity" EXACT [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015771 ! trehalose transport [Term] id: GO:0015575 name: mannitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015586 def: "Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol permease activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015797 ! mannitol transport [Term] id: GO:0015576 name: sorbitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015587 def: "Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] synonym: "glucitol permease activity" EXACT [] synonym: "glucitol transporter activity" EXACT [] synonym: "sorbitol permease activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity relationship: part_of GO:0015795 ! sorbitol transport [Term] id: GO:0015577 name: galactitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015588 def: "Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol permease activity" EXACT [] xref: RHEA:33143 is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015796 ! galactitol transport [Term] id: GO:0015578 name: mannose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015589 def: "Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "mannose permease activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015761 ! mannose transmembrane transport [Term] id: GO:0015583 name: obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it arbitrarily groups three substrates. synonym: "beta-glucoside [arbutin-salicin-cellobiose] permease activity" EXACT [] is_obsolete: true [Term] id: GO:0015591 name: D-ribose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015146 ! pentose transmembrane transporter activity relationship: part_of GO:0015752 ! D-ribose transmembrane transport [Term] id: GO:0015592 name: methylgalactoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015765 ! methylgalactoside transport [Term] id: GO:0015593 name: allose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015754 ! allose transmembrane transport [Term] id: GO:0015594 name: ATPase-coupled putrescine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)." [EC:7.6.2.11] synonym: "putrescine porter activity" BROAD [] synonym: "putrescine-importing ATPase activity" RELATED [] xref: RHEA:29995 is_a: GO:0015417 ! ATPase-coupled polyamine transmembrane transporter activity is_a: GO:0015489 ! putrescine transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015595 name: ATPase-coupled spermidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + spermidine(out) -> ADP + phosphate + spermidine(in)." [EC:3.6.3.31] synonym: "spermidine porter activity" BROAD [] synonym: "spermidine-importing ATPase activity" RELATED [] xref: MetaCyc:ABC-24-RXN xref: RHEA:29999 is_a: GO:0015417 ! ATPase-coupled polyamine transmembrane transporter activity is_a: GO:0015606 ! spermidine transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015596 name: obsolete glycine betaine/proline porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glycine betaine/proline porter activity" EXACT [] is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015418 [Term] id: GO:0015597 name: obsolete histidine/arginine/lysine/ornithine porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "histidine/arginine/lysine/ornithine porter activity" EXACT [] is_obsolete: true consider: GO:0000064 consider: GO:0005290 consider: GO:0015181 consider: GO:0015189 consider: GO:0015426 [Term] id: GO:0015599 name: ATPase-coupled L-glutamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)." [EC:7.4.2.1] synonym: "ATPase-coupled glutamine transmembrane transporter activity" BROAD [] synonym: "glutamine porter activity" BROAD [] synonym: "glutamine-importing ATPase activity" RELATED [] xref: EC:7.4.2.1 xref: MetaCyc:ABC-12-RXN is_a: GO:0015186 ! L-glutamine transmembrane transporter activity is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity [Term] id: GO:0015600 name: obsolete glutamate/aspartate porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glutamate/aspartate porter activity" EXACT [] is_obsolete: true consider: GO:0005313 consider: GO:0015183 consider: GO:0015426 [Term] id: GO:0015601 name: obsolete cystine/diaminopimelate porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "cystine/diaminopimelate porter activity" EXACT [] is_obsolete: true consider: GO:0015184 consider: GO:0015426 consider: GO:0015626 [Term] id: GO:0015602 name: obsolete leucine/isoleucine/valine porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "leucine/isoleucine/valine porter activity" EXACT [] is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0015425 [Term] id: GO:0015603 name: iron chelate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0033214 ! siderophore-dependent iron import into cell [Term] id: GO:0015604 name: organic phosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015716 ! organic phosphonate transport [Term] id: GO:0015605 name: organophosphate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015748 ! organophosphate ester transport [Term] id: GO:0015606 name: spermidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity relationship: part_of GO:1903711 ! spermidine transmembrane transport [Term] id: GO:0015607 name: ATPase-coupled fatty-acyl-CoA transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction ATP + H(2)O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [EC:7.6.2.4] synonym: "ABC-type fatty-acyl-CoA transporter" EXACT [EC:7.6.2.4] synonym: "fatty acyl CoA transporter activity" EXACT [] synonym: "fatty-acyl-CoA transmembrane transporter activity" BROAD [] synonym: "fatty-acyl-CoA-transporting ATPase" EXACT [EC:7.6.2.4] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0033220 ! ATPase-coupled amide-transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015916 ! fatty-acyl-CoA transport [Term] id: GO:0015608 name: carbohydrate-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-] synonym: "carbohydrate uptake transporter activity" EXACT [] synonym: "sugar transporter" NARROW [] is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0015611 name: D-ribose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "D-ribose porter activity" BROAD [] xref: MetaCyc:ABC-28-RXN is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity is_a: GO:0015591 ! D-ribose transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015612 name: L-arabinose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "L-arabinose porter activity" EXACT [] xref: MetaCyc:ABC-2-RXN is_a: GO:0015147 ! L-arabinose transmembrane transporter activity is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015613 name: obsolete galactose/glucose (methylgalactoside) porter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "galactose/glucose (methylgalactoside) porter activity" EXACT [] is_obsolete: true consider: GO:0005354 consider: GO:0005355 consider: GO:0015291 consider: GO:0015592 [Term] id: GO:0015614 name: ATPase-coupled D-xylose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)." [RHEA:29902] synonym: "D-xylose porter activity" BROAD [] synonym: "D-xylose-importing ATPase activity" RELATED [] xref: RHEA:29902 is_a: GO:0015148 ! D-xylose transmembrane transporter activity is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity [Term] id: GO:0015615 name: D-allose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-] synonym: "D-allose porter activity" BROAD [] is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity is_a: GO:0015593 ! allose transmembrane transporter activity [Term] id: GO:0015616 name: DNA translocase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491] comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: has_part GO:0003677 ! DNA binding [Term] id: GO:0015617 name: obsolete pilin/fimbrilin exporter activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "pilin/fimbrilin exporter activity" EXACT [] is_obsolete: true consider: GO:0015462 [Term] id: GO:0015620 name: ferric-enterobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] is_a: GO:0015343 ! siderophore transmembrane transporter activity relationship: part_of GO:0015685 ! ferric-enterobactin import into cell [Term] id: GO:0015621 name: ferric triacetylfusarinine C transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015623 name: ATPase-coupled iron-chelate transporter activity namespace: molecular_function alt_id: GO:0015409 alt_id: GO:0102026 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:7.2.2.16] synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:7.2.2.16] synonym: "ATP-dependent iron-chelate transporter activity" EXACT [] synonym: "ferric dicitrate transporter activity" NARROW [] synonym: "ferric/ferric-dicitrate porter" BROAD [] synonym: "iron-chelate ABC transporter" NARROW [] synonym: "iron-chelate-transporting ATPase activity" EXACT [] xref: EC:7.2.2.16 xref: MetaCyc:3.6.3.34-RXN xref: MetaCyc:ABC-9-RXN is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0015624 name: ATPase-coupled ferric-enterobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [EC:7.2.2.17] synonym: "ATP-dependent ferric-enterobactin transmembrane transporter activity" EXACT [] synonym: "ferric-enterobactin ABC transporter" NARROW [] synonym: "ferric-enterobactin porter activity" BROAD [] synonym: "ferric-enterobactin-transporting ATPase activity" EXACT [] xref: MetaCyc:ABC-10-RXN is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015623 ! ATPase-coupled iron-chelate transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015625 name: ATPase-coupled ferric-hydroxamate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015622 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [EC:7.2.2.16] synonym: "ATP-dependent ferric-hydroxamate transmembrane transporter activity" EXACT [] synonym: "ferric-hydroxamate ABC transporter" NARROW [] synonym: "ferric-hydroxamate porter activity" BROAD [] synonym: "ferric-hydroxamate transmembrane transporter activity" BROAD [] synonym: "ferric-hydroxamate-transporting ATPase activity" EXACT [] xref: EC:7.2.2.16 xref: MetaCyc:ABC-11-RXN is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015623 ! ATPase-coupled iron-chelate transporter activity is_a: GO:0033220 ! ATPase-coupled amide-transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015626 name: L-diaminopimelate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-diaminopimelate transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015830 ! diaminopimelate transport [Term] id: GO:0015627 name: type II protein secretion system complex namespace: cellular_component def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. synonym: "general secretion pathway-associated complex" RELATED [] synonym: "main terminal branch" EXACT [] synonym: "MTB" EXACT [] synonym: "Sec-dependent secretion system-associated complex" RELATED [] synonym: "T2SS-associated complexes" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0015628 name: protein secretion by the type II secretion system namespace: biological_process def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. synonym: "protein secretion by the general secretion pathway" RELATED [] synonym: "protein secretion by the general secretory pathway" RELATED [] synonym: "protein secretion by the T2S" EXACT [] synonym: "protein secretion by the T2SS" EXACT [] synonym: "protein secretion by the type II protein secretion system" EXACT [] synonym: "type II protein secretion system" EXACT [] xref: MIPS_funcat:20.09.16.02 is_a: GO:0009306 ! protein secretion is_a: GO:0098776 ! protein transport across the cell outer membrane [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] subset: goslim_aspergillus xref: MIPS_funcat:70.04.03 is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] subset: goslim_aspergillus xref: MIPS_funcat:70.04.05 is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0015633 name: ATPase-coupled zinc transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-] synonym: "ATP-dependent zinc transmembrane transporter activity" EXACT [] synonym: "zinc porter activity" RELATED [] synonym: "zinc transporting ATPase activity" RELATED [] synonym: "zinc-transporting ATPase activity" EXACT [] xref: RHEA:29795 is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0015634 name: obsolete lipopolysaccharide exporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] comment: This term was obsoleted because 'export' represents a process, not a function. See https://github.com/geneontology/go-ontology/issues/17202. synonym: "LPS exporter activity" EXACT [] is_obsolete: true [Term] id: GO:0015636 name: short-chain fatty acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015635 def: "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:mah] synonym: "short-chain fatty acid transporter activity" RELATED [] synonym: "short-chain fatty acid uptake transporter activity" RELATED [] is_a: GO:0015245 ! fatty acid transmembrane transporter activity relationship: part_of GO:0015912 ! short-chain fatty acid transport [Term] id: GO:0015638 name: microcin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a microcin from one side of a membrane to the other." [GOC:mah] synonym: "microcin uptake permease activity" EXACT [] is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0042884 ! microcin transport [Term] id: GO:0015640 name: peptidoglycan peptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] synonym: "murein peptide transporter activity" EXACT [] synonym: "muropeptide transporter activity" EXACT [] is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity relationship: part_of GO:0015834 ! peptidoglycan-associated peptide transport [Term] id: GO:0015641 name: obsolete lipoprotein toxin namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "lipoprotein toxin" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0015642 name: obsolete bacteriolytic toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products and not a molecular function. synonym: "bacteriolytic toxin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015643 name: toxic substance binding namespace: molecular_function def: "Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr] synonym: "antitoxin activity" RELATED [] synonym: "lipoprotein antitoxin" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0015644 name: obsolete lipoprotein antitoxin namespace: molecular_function def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl] comment: This term was made obsolete because it does not represent a function distinct from its parent term. synonym: "lipoprotein antitoxin" EXACT [] is_obsolete: true replaced_by: GO:0015643 [Term] id: GO:0015645 name: fatty acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.3, GOC:cjk, GOC:mah] synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "fatty-acid ligase activity" EXACT [] is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0015647 name: peptidoglycan transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other." [GOC:ai] synonym: "murein transporter activity" EXACT [] is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0015835 ! peptidoglycan transport [Term] id: GO:0015648 name: lipid-linked peptidoglycan transporter activity namespace: molecular_function def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah] synonym: "lipid-linked murein transporter activity" EXACT [] is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity relationship: part_of GO:0015836 ! lipid-linked peptidoglycan transport [Term] id: GO:0015649 name: 2-keto-3-deoxygluconate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity relationship: part_of GO:0046411 ! 2-keto-3-deoxygluconate transmembrane transport [Term] id: GO:0015650 name: lactate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] synonym: "lactate permease" BROAD [] synonym: "lactate:hydrogen porter activity" EXACT [] synonym: "lactate:hydrogen symporter activity" EXACT [] synonym: "lactate:proton porter activity" EXACT [] is_a: GO:0015129 ! lactate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015651 name: quaternary ammonium group transmembrane transporter activity namespace: molecular_function alt_id: GO:0015202 def: "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732] synonym: "quaternary amine transmembrane transporter activity" EXACT [] synonym: "quaternary ammonium compound transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity relationship: part_of GO:0015697 ! quaternary ammonium group transport [Term] id: GO:0015652 name: quaternary ammonium group:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] synonym: "quaternary ammonium group:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015653 name: glycine betaine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] synonym: "glycine betaine:hydrogen symporter activity" EXACT [] is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity is_a: GO:0015652 ! quaternary ammonium group:proton symporter activity relationship: part_of GO:0031460 ! glycine betaine transport [Term] id: GO:0015654 name: tellurite transmembrane transporter activity namespace: molecular_function alt_id: GO:0015118 def: "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai] synonym: "tellurite uptake transmembrane transporter activity" RELATED [] synonym: "tellurite-resistance uptake permease activity" RELATED [] synonym: "tellurite-resistance uptake transmembrane transporter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015655 name: alanine:sodium symporter activity namespace: molecular_function alt_id: GO:0044670 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] synonym: "sodium:alanine symporter activity" EXACT [] xref: RHEA:29283 is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity created_by: janelomax creation_date: 2012-08-08T12:57:30Z [Term] id: GO:0015657 name: branched-chain amino acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity is_a: GO:0140323 ! solute:anion antiporter activity [Term] id: GO:0015658 name: branched-chain amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:1901240 def: "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729] synonym: "branched-chain aliphatic amino acid transmembrane transporter activity" EXACT [GOC:bf] synonym: "branched-chain aliphatic amino acid transporter activity" EXACT [] synonym: "leucine/valine/isoleucine permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015803 ! branched-chain amino acid transport [Term] id: GO:0015660 name: formate efflux transmembrane transporter activity namespace: molecular_function alt_id: GO:0015509 def: "Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate efflux permease activity" RELATED [] is_a: GO:0015499 ! formate transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015661 name: L-lysine efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-lysine exporter activity" EXACT [] synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] is_a: GO:0015189 ! L-lysine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015662 name: ion transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] synonym: "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" EXACT [] synonym: "P-type ATPase activity" EXACT [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: Reactome:R-HSA-429157 "ABCC4 accumulation of dense granule contents" is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0015663 name: nicotinamide mononucleotide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015664 def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544] synonym: "nicotinamide mononucleotide permease activity" RELATED [] synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0035353 ! nicotinamide mononucleotide transmembrane transport [Term] id: GO:0015665 name: alcohol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732] is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015666 name: restriction endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] synonym: "restriction endonuclease activity" EXACT [] synonym: "restriction enzyme activity" EXACT [] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0015667 name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113] synonym: "modification methylase activity" RELATED [EC:2.1.1.113] synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] xref: EC:2.1.1.113 xref: MetaCyc:2.1.1.113-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0090124 ! N-4 methylation of cytosine [Term] id: GO:0015668 name: type III site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] synonym: "type III restriction enzyme activity" EXACT [] xref: EC:3.1.21.5 xref: MetaCyc:3.1.21.5-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0015670 name: carbon dioxide transport namespace: biological_process def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport is_a: GO:0015893 ! drug transport is_a: GO:0019755 ! one-carbon compound transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015672 name: monovalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006812 ! cation transport [Term] id: GO:0015673 name: silver ion transport namespace: biological_process def: "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "silver transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015675 name: nickel cation transport namespace: biological_process def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015676 name: vanadium ion transport namespace: biological_process def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015677 name: copper ion import namespace: biological_process def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006825 ! copper ion transport [Term] id: GO:0015679 name: plasma membrane copper ion transport namespace: biological_process def: "The directed movement of copper ions across the plasma membrane." [GOC:ai] synonym: "plasma membrane copper transport" EXACT [] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0015680 name: protein maturation by copper ion transfer namespace: biological_process def: "A process that contributes to the delivery of copper ions to a target protein." [GOC:ai] synonym: "intracellular copper delivery" EXACT [] synonym: "intracellular copper ion delivery" RELATED [] synonym: "intracellular copper ion transport" BROAD [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0015685 name: ferric-enterobactin import into cell namespace: biological_process def: "A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] synonym: "ferric-enterobactin transport" BROAD [] is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0042930 ! enterobactin transport [Term] id: GO:0015686 name: ferric triacetylfusarinine C import into cell namespace: biological_process def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "ferric triacetylfusarinine C transport" BROAD [] is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015687 name: ferric-hydroxamate import into cell namespace: biological_process def: "A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] synonym: "ferric-hydroxamate transport" BROAD [] is_a: GO:0015711 ! organic anion transport is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0042886 ! amide transport [Term] id: GO:0015689 name: molybdate ion transport namespace: biological_process def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015690 name: aluminum cation transport namespace: biological_process def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "aluminium ion transport" EXACT [] synonym: "aluminium transport" EXACT [] synonym: "aluminum ion transport" RELATED [] synonym: "aluminum transport" EXACT [] is_a: GO:0030001 ! metal ion transport is_a: GO:0072512 ! trivalent inorganic cation transport [Term] id: GO:0015691 name: cadmium ion transport namespace: biological_process def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cadmium transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015692 name: lead ion transport namespace: biological_process def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0015693 name: magnesium ion transport namespace: biological_process def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "magnesium transport" RELATED [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015694 name: mercury ion transport namespace: biological_process def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mercuric ion transport" NARROW [] synonym: "mercury transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport relationship: part_of GO:0050787 ! detoxification of mercury ion [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006812 ! cation transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015696 name: ammonium transport namespace: biological_process def: "The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732] synonym: "ammonia transport" RELATED [] is_a: GO:0006812 ! cation transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015697 name: quaternary ammonium group transport namespace: biological_process alt_id: GO:0015845 def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732] synonym: "quaternary amine transport" EXACT [] synonym: "quaternary ammonium compound transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006820 ! anion transport [Term] id: GO:0015699 name: antimonite transport namespace: biological_process def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015700 name: arsenite transport namespace: biological_process def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015701 name: bicarbonate transport namespace: biological_process def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015702 name: chlorate transport namespace: biological_process def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015703 name: chromate transport namespace: biological_process def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015704 name: cyanate transport namespace: biological_process def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006820 ! anion transport is_a: GO:0019755 ! one-carbon compound transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015705 name: iodide transport namespace: biological_process def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015706 name: nitrate transport namespace: biological_process alt_id: GO:0006872 alt_id: GO:0080055 def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "low affinity nitrate transport" NARROW [] synonym: "low-affinity nitrate transport" NARROW [] xref: MIPS_funcat:20.01.01.07.01 is_a: GO:0015698 ! inorganic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015707 name: nitrite transport namespace: biological_process def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] xref: MIPS_funcat:20.01.01.07.03 is_a: GO:0015698 ! inorganic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015708 name: silicic acid import across plasma membrane namespace: biological_process alt_id: GO:0051207 alt_id: GO:1902067 def: "The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, GOC:krc, http://www.onelook.com] synonym: "silicate transport" BROAD [] synonym: "silicic acid import" RELATED [] synonym: "silicic acid transport" EXACT [] synonym: "silicon uptake" RELATED [] is_a: GO:0098661 ! inorganic anion transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: tb creation_date: 2013-04-17T20:53:16Z [Term] id: GO:0015709 name: thiosulfate transport namespace: biological_process def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "thiosulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015710 name: tellurite transport namespace: biological_process def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015712 name: hexose phosphate transport namespace: biological_process def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015713 name: phosphoglycerate transmembrane transport namespace: biological_process def: "The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "phosphoglycerate transport" RELATED [] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0042873 ! aldonate transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015714 name: phosphoenolpyruvate transport namespace: biological_process def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0015715 name: nucleotide-sulfate transport namespace: biological_process def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "nucleotide-sulphate transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0015711 ! organic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015716 name: organic phosphonate transport namespace: biological_process def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015717 name: triose phosphate transport namespace: biological_process def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "aldotriose phosphate transport" EXACT [] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015719 name: allantoate transport namespace: biological_process def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "allantoin/allantoate transport" BROAD [] xref: MIPS_funcat:20.01.23 is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015720 name: allantoin transport namespace: biological_process def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "allantoin transmembrane transport" EXACT [GOC:mah] synonym: "allantoin/allantoate transport" BROAD [] xref: MIPS_funcat:20.01.23 is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015721 name: bile acid and bile salt transport namespace: biological_process def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] synonym: "bile acid transport" NARROW [] synonym: "bile salt transport" NARROW [] is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015722 name: canalicular bile acid transport namespace: biological_process def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015721 ! bile acid and bile salt transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0015723 name: bilirubin transport namespace: biological_process def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015724 name: formate transport namespace: biological_process def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015726 name: L-idonate transmembrane transport namespace: biological_process def: "The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc] synonym: "L-idonate transport" RELATED [] is_a: GO:0042873 ! aldonate transmembrane transport [Term] id: GO:0015727 name: lactate transport namespace: biological_process def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015728 name: mevalonate transport namespace: biological_process def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015729 name: oxaloacetate transport namespace: biological_process def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015730 name: propanoate transport namespace: biological_process def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "propionate transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0015912 ! short-chain fatty acid transport [Term] id: GO:0015731 name: 3-hydroxyphenyl propanoate transport namespace: biological_process def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "3-hydroxyphenyl propionate transport" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015732 name: prostaglandin transport namespace: biological_process def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015908 ! fatty acid transport is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0015733 name: shikimate transmembrane transport namespace: biological_process def: "The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "shikimate transport" RELATED [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015734 name: taurine transport namespace: biological_process def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0042918 ! alkanesulfonate transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015735 name: uronic acid transmembrane transport namespace: biological_process def: "The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "uronic acid transport" RELATED [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015736 name: hexuronate transmembrane transport namespace: biological_process def: "The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732] synonym: "hexuronate transport" RELATED [] is_a: GO:0015735 ! uronic acid transmembrane transport [Term] id: GO:0015737 name: galacturonate transmembrane transport namespace: biological_process def: "The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "galacturonate transport" RELATED [] is_a: GO:0015736 ! hexuronate transmembrane transport [Term] id: GO:0015738 name: glucuronate transmembrane transport namespace: biological_process def: "The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "glucuronate transport" RELATED [] is_a: GO:0015736 ! hexuronate transmembrane transport [Term] id: GO:0015739 name: sialic acid transport namespace: biological_process def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015740 name: C4-dicarboxylate transport namespace: biological_process def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah] xref: MIPS_funcat:20.01.03.03 is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015741 name: fumarate transport namespace: biological_process def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015742 name: alpha-ketoglutarate transport namespace: biological_process def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "2-oxoglutarate transport" EXACT [] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015743 name: malate transport namespace: biological_process def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015744 name: succinate transport namespace: biological_process def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015745 name: tartrate transmembrane transport namespace: biological_process def: "The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "tartrate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0042869 ! aldarate transmembrane transport [Term] id: GO:0015746 name: citrate transport namespace: biological_process def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006842 ! tricarboxylic acid transport [Term] id: GO:0015747 name: urate transport namespace: biological_process def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "urate transmembrane transport" EXACT [GOC:mah] synonym: "uric acid transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015748 name: organophosphate ester transport namespace: biological_process def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015749 name: monosaccharide transmembrane transport namespace: biological_process alt_id: GO:1905950 def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] synonym: "monosaccharide transport" RELATED [] is_a: GO:0034219 ! carbohydrate transmembrane transport created_by: vw creation_date: 2017-02-19T10:41:27Z [Term] id: GO:0015750 name: pentose transmembrane transport namespace: biological_process def: "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai] synonym: "pentose transport" RELATED [] is_a: GO:0015749 ! monosaccharide transmembrane transport [Term] id: GO:0015751 name: arabinose transmembrane transport namespace: biological_process def: "The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] synonym: "arabinose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015752 name: D-ribose transmembrane transport namespace: biological_process def: "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai] synonym: "D-ribose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015753 name: D-xylose transmembrane transport namespace: biological_process def: "The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai] synonym: "D-xylose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015754 name: allose transmembrane transport namespace: biological_process def: "The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai] synonym: "allose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015755 name: fructose transmembrane transport namespace: biological_process def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai] synonym: "fructose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015756 name: fucose transmembrane transport namespace: biological_process def: "The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai] synonym: "fucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015757 name: galactose transmembrane transport namespace: biological_process def: "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai] synonym: "galactose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015759 name: beta-glucoside transport namespace: biological_process def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0015760 name: glucose-6-phosphate transport namespace: biological_process def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015712 ! hexose phosphate transport [Term] id: GO:0015761 name: mannose transmembrane transport namespace: biological_process def: "The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai] synonym: "mannose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015762 name: rhamnose transmembrane transport namespace: biological_process def: "The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai] synonym: "rhamnose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015763 name: N-acetylgalactosamine transport namespace: biological_process def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015764 name: N-acetylglucosamine transport namespace: biological_process def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015765 name: methylgalactoside transport namespace: biological_process def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:curators] is_a: GO:1901656 ! glycoside transport [Term] id: GO:0015766 name: disaccharide transport namespace: biological_process def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai] is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0015767 name: lactose transport namespace: biological_process def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015768 name: maltose transport namespace: biological_process def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015769 name: melibiose transport namespace: biological_process def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015770 name: sucrose transport namespace: biological_process def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015771 name: trehalose transport namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015772 name: oligosaccharide transport namespace: biological_process def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015773 name: raffinose transport namespace: biological_process def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732] is_a: GO:2001088 ! trisaccharide transport [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport relationship: part_of GO:0033037 ! polysaccharide localization [Term] id: GO:0015775 name: beta-glucan transport namespace: biological_process def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015776 name: capsular polysaccharide transport namespace: biological_process def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] synonym: "capsular-polysaccharide transport" EXACT [] synonym: "capsule polysaccharide transport" EXACT [] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015777 name: teichoic acid transport namespace: biological_process def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015778 name: hexuronide transport namespace: biological_process def: "The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015779 name: glucuronoside transport namespace: biological_process def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai] synonym: "glucuronide transport" EXACT [] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901656 ! glycoside transport [Term] id: GO:0015780 name: nucleotide-sugar transmembrane transport namespace: biological_process def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar transport" RELATED [] is_a: GO:0015931 ! nucleobase-containing compound transport is_a: GO:0055085 ! transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015782 name: CMP-N-acetylneuraminate transmembrane transport namespace: biological_process def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "CMP-N-acetylneuraminate transport" RELATED [] synonym: "CMP-sialic acid transport" BROAD [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015783 name: GDP-fucose transmembrane transport namespace: biological_process def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-fucose transport" RELATED [] is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport [Term] id: GO:0015786 name: UDP-glucose transmembrane transport namespace: biological_process def: "The process in which UDP-glucose is transported across a membrane." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015787 name: UDP-glucuronic acid transmembrane transport namespace: biological_process def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucuronic acid transport" RELATED [] is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015789 name: UDP-N-acetylgalactosamine transmembrane transport namespace: biological_process def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015790 name: UDP-xylose transmembrane transport namespace: biological_process def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-xylose transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015791 name: polyol transport namespace: biological_process def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015792 name: arabinitol transmembrane transport namespace: biological_process def: "The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "arabinitol transport" RELATED [] synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0015791 ! polyol transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0015793 name: glycerol transport namespace: biological_process def: "The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015794 name: glycerol-3-phosphate transmembrane transport namespace: biological_process def: "The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] synonym: "glycerol-3-phosphate transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015795 name: sorbitol transport namespace: biological_process def: "The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] synonym: "glucitol transport" EXACT [] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015796 name: galactitol transport namespace: biological_process def: "The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015797 name: mannitol transport namespace: biological_process def: "The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015798 name: myo-inositol transport namespace: biological_process def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] synonym: "vitamin Bh transport" EXACT [] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015799 name: propanediol transport namespace: biological_process def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015801 name: aromatic amino acid transport namespace: biological_process def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015802 name: basic amino acid transport namespace: biological_process def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015803 name: branched-chain amino acid transport namespace: biological_process alt_id: GO:1900755 def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf] synonym: "branched-chain aliphatic amino acid transport" EXACT [] synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl] synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015805 name: S-adenosyl-L-methionine transport namespace: biological_process def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "S-adenosyl methionine transport" EXACT [] synonym: "S-adenosylmethionine transport" EXACT [] synonym: "SAM transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015806 name: S-methylmethionine transport namespace: biological_process def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015808 name: L-alanine transport namespace: biological_process def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032328 ! alanine transport [Term] id: GO:0015809 name: arginine transport namespace: biological_process def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] synonym: "L-arginine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015810 name: aspartate transmembrane transport namespace: biological_process def: "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015811 name: L-cystine transport namespace: biological_process def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015812 name: gamma-aminobutyric acid transport namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006865 ! amino acid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015813 name: L-glutamate transmembrane transport namespace: biological_process alt_id: GO:0089711 def: "The directed movement of L-glutamate across a membrane." [PMID:21307582] synonym: "L-glutamate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] id: GO:0015814 name: p-aminobenzoyl-glutamate transport namespace: biological_process def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042938 ! dipeptide transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006812 ! cation transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015817 name: histidine transport namespace: biological_process def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-histidine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015818 name: isoleucine transport namespace: biological_process def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-isoleucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015819 name: lysine transport namespace: biological_process alt_id: GO:0034226 alt_id: GO:0061461 def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-lysine import" NARROW [] synonym: "L-lysine transport" NARROW [] synonym: "lysine import" NARROW [] synonym: "lysine uptake" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport created_by: dph creation_date: 2012-10-05T10:22:26Z [Term] id: GO:0015820 name: leucine transport namespace: biological_process def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-leucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015821 name: methionine transport namespace: biological_process def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-methionine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0006812 ! cation transport [Term] id: GO:0015822 name: ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-ornithine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015823 name: phenylalanine transport namespace: biological_process def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-phenylalanine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015824 name: proline transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-proline transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015825 name: L-serine transport namespace: biological_process alt_id: GO:0090479 def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-serine import" NARROW [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032329 ! serine transport created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0015826 name: threonine transport namespace: biological_process def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-threonine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015827 name: tryptophan transport namespace: biological_process def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-tryptophan transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015828 name: tyrosine transport namespace: biological_process def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-tyrosine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015829 name: valine transport namespace: biological_process def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-valine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015830 name: diaminopimelate transport namespace: biological_process def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015832 name: obsolete holin namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of gene products. synonym: "holin" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir xref: MIPS_funcat:20.01.09 is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015834 name: peptidoglycan-associated peptide transport namespace: biological_process def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] synonym: "murein peptide transport" EXACT [] synonym: "muropeptide transport" EXACT [] synonym: "peptidoglycan peptide transport" EXACT [GOC:mah] is_a: GO:0015833 ! peptide transport [Term] id: GO:0015835 name: peptidoglycan transport namespace: biological_process def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir synonym: "murein transport" EXACT [] is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015836 name: lipid-linked peptidoglycan transport namespace: biological_process def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "lipid-linked murein transport" EXACT [] is_a: GO:0015835 ! peptidoglycan transport [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] xref: MIPS_funcat:20.01.11 is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015838 name: amino-acid betaine transport namespace: biological_process def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "betaine transport" EXACT [] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015839 name: cadaverine transport namespace: biological_process def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015840 name: urea transport namespace: biological_process def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732] is_a: GO:0019755 ! one-carbon compound transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015841 name: chromaffin granule amine transport namespace: biological_process def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah] is_a: GO:0015837 ! amine transport [Term] id: GO:0015842 name: aminergic neurotransmitter loading into synaptic vesicle namespace: biological_process def: "The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:ai] is_a: GO:0015837 ! amine transport is_a: GO:0098700 ! neurotransmitter loading into synaptic vesicle [Term] id: GO:0015843 name: methylammonium transport namespace: biological_process def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015837 ! amine transport is_a: GO:0019755 ! one-carbon compound transport [Term] id: GO:0015844 name: monoamine transport namespace: biological_process alt_id: GO:0015873 def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015846 name: polyamine transport namespace: biological_process def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] xref: MIPS_funcat:20.01.11 is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015847 name: putrescine transport namespace: biological_process def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015848 name: spermidine transport namespace: biological_process def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai] synonym: "organic alcohol transport" EXACT [] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015853 name: adenine transport namespace: biological_process def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] synonym: "adenine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport [Term] id: GO:0015854 name: guanine transport namespace: biological_process def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0006863 ! purine nucleobase transport [Term] id: GO:0015855 name: pyrimidine nucleobase transport namespace: biological_process def: "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah] synonym: "pyrimidine base transport" EXACT [GOC:go_curators] synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah] synonym: "pyrimidine transport" RELATED [] is_a: GO:0015851 ! nucleobase transport [Term] id: GO:0015856 name: cytosine transport namespace: biological_process def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] synonym: "cytosine transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine nucleobase transport [Term] id: GO:0015857 name: uracil transport namespace: biological_process def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015855 ! pyrimidine nucleobase transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015858 name: nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: MIPS_funcat:20.01.19 is_a: GO:0015931 ! nucleobase-containing compound transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015859 name: intracellular nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai] is_a: GO:0015858 ! nucleoside transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0015858 ! nucleoside transport intersection_of: occurs_in GO:0005622 ! intracellular [Term] id: GO:0015860 name: purine nucleoside transmembrane transport namespace: biological_process alt_id: GO:0035427 def: "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar." [GOC:ai, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "purine nucleoside membrane transport" EXACT [] synonym: "purine nucleoside transport" BROAD [GOC:vw] is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901642 ! nucleoside transmembrane transport [Term] id: GO:0015861 name: cytidine transport namespace: biological_process def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015862 name: uridine transport namespace: biological_process def: "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015863 name: xanthosine transport namespace: biological_process def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0015864 name: pyrimidine nucleoside transport namespace: biological_process def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0015865 name: purine nucleotide transport namespace: biological_process def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0015866 name: ADP transport namespace: biological_process def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015867 name: ATP transport namespace: biological_process def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0015893 ! drug transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015868 name: purine ribonucleotide transport namespace: biological_process def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015869 name: protein-DNA complex transport namespace: biological_process def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "DNA-protein complex transport" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0051027 ! DNA transport [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015893 ! drug transport is_a: GO:1901374 ! acetate ester transport [Term] id: GO:0015871 name: choline transport namespace: biological_process def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015872 name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0015696 ! ammonium transport is_a: GO:0015893 ! drug transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015875 name: obsolete vitamin or cofactor transport namespace: biological_process def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "vitamin or cofactor transport" EXACT [] is_obsolete: true consider: GO:0051180 consider: GO:0051181 [Term] id: GO:0015876 name: acetyl-CoA transport namespace: biological_process def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] is_a: GO:0015916 ! fatty-acyl-CoA transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015877 name: biopterin transport namespace: biological_process def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015878 name: biotin transport namespace: biological_process def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transport" EXACT [] synonym: "vitamin H transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015879 name: carnitine transport namespace: biological_process def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] synonym: "vitamin Bt transport" EXACT [] is_a: GO:0015838 ! amino-acid betaine transport [Term] id: GO:0015880 name: coenzyme A transport namespace: biological_process def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015881 name: creatine transmembrane transport namespace: biological_process alt_id: GO:1902598 def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "creatine transport" BROAD [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: pr creation_date: 2013-12-20T11:01:18Z [Term] id: GO:0015882 name: L-ascorbic acid transmembrane transport namespace: biological_process def: "The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:ai] synonym: "L-ascorbate transport" EXACT [] synonym: "L-ascorbic acid transport" RELATED [] synonym: "vitamin C transport" EXACT [] is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0051182 ! coenzyme transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015883 name: FAD transport namespace: biological_process def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] synonym: "flavin adenine dinucleotide transport" EXACT [] synonym: "flavin-adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0015711 ! organic anion transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015884 name: folic acid transport namespace: biological_process def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transport" EXACT [] synonym: "vitamin B9 transport" EXACT [] synonym: "vitamin M transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015885 name: 5-formyltetrahydrofolate transport namespace: biological_process def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042886 ! amide transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015886 name: heme transport namespace: biological_process def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "haem transport" EXACT [] is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901678 ! iron coordination entity transport [Term] id: GO:0015887 name: pantothenate transmembrane transport namespace: biological_process def: "The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pantothenate membrane transport" EXACT [] synonym: "pantothenate transport" EXACT [GOC:mah] synonym: "vitamin B5 transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015888 name: thiamine transport namespace: biological_process def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] synonym: "thiamin transport" EXACT [] synonym: "vitamin B1 transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015889 name: cobalamin transport namespace: biological_process def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "vitamin B12 transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015890 name: nicotinamide mononucleotide transport namespace: biological_process def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544] synonym: "nicotinamide ribonucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0051181 ! cofactor transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015891 name: siderophore transport namespace: biological_process alt_id: GO:0015892 def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir synonym: "iron-siderochrome transport" NARROW [] synonym: "iron-siderophore transport" EXACT [] synonym: "siderochrome transport" NARROW [] synonym: "siderophore-iron transport" EXACT [] is_a: GO:1901678 ! iron coordination entity transport [Term] id: GO:0015893 name: drug transport namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir xref: MIPS_funcat:20.01.27 is_a: GO:0006810 ! transport relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0015894 name: acriflavine transport namespace: biological_process def: "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842] synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0006821 ! chloride transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0015895 name: alkane transport namespace: biological_process def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015896 name: nalidixic acid transport namespace: biological_process def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015897 name: organomercurial transport namespace: biological_process def: "The process in which an organomercurial compound is transported across a membrane.\nOrganomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015898 name: amiloride transport namespace: biological_process def: "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015899 name: aminotriazole transport namespace: biological_process def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [GOC:curators] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015900 name: benomyl transport namespace: biological_process def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [GOC:curators] is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015901 name: cycloheximide transport namespace: biological_process def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015902 name: carbonyl cyanide m-chlorophenylhydrazone transport namespace: biological_process def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators] synonym: "CCCP transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015903 name: fluconazole transport namespace: biological_process def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015904 name: tetracycline transmembrane transport namespace: biological_process def: "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators] synonym: "tetracyclin transport" BROAD [] synonym: "tetracycline transport" BROAD [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015905 name: bicyclomycin transmembrane transport namespace: biological_process def: "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [PMID:20067529] synonym: "bicyclomycin transport" BROAD [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015908 name: fatty acid transport namespace: biological_process def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015909 name: long-chain fatty acid transport namespace: biological_process def: "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015910 name: long-chain fatty acid import into peroxisome namespace: biological_process def: "The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] synonym: "peroxisomal long-chain fatty acid import" EXACT [] synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0015919 ! peroxisomal membrane transport is_a: GO:0032365 ! intracellular lipid transport is_a: GO:1902001 ! fatty acid transmembrane transport [Term] id: GO:0015911 name: long-chain fatty acid import across plasma membrane namespace: biological_process def: "The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] synonym: "plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0044539 ! long-chain fatty acid import into cell is_a: GO:0098739 ! import across plasma membrane is_a: GO:1902001 ! fatty acid transmembrane transport [Term] id: GO:0015912 name: short-chain fatty acid transport namespace: biological_process def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015913 name: short-chain fatty acid import namespace: biological_process def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:ai] synonym: "short-chain fatty acid uptake" EXACT [] is_a: GO:0015912 ! short-chain fatty acid transport [Term] id: GO:0015914 name: phospholipid transport namespace: biological_process def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0015915 name: fatty-acyl group transport namespace: biological_process def: "The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai] synonym: "fatty acyl transport" EXACT [] is_a: GO:0006810 ! transport [Term] id: GO:0015916 name: fatty-acyl-CoA transport namespace: biological_process def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732] synonym: "fatty acyl CoA transport" EXACT [] synonym: "fatty acyl coenzyme A transport" EXACT [] synonym: "fatty acyl-CoA transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0042886 ! amide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:1901337 ! thioester transport [Term] id: GO:0015917 name: aminophospholipid transport namespace: biological_process def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] is_a: GO:0015914 ! phospholipid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015918 name: sterol transport namespace: biological_process def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015919 name: peroxisomal membrane transport namespace: biological_process def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai] is_a: GO:0043574 ! peroxisomal transport [Term] id: GO:0015920 name: lipopolysaccharide transport namespace: biological_process def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai] subset: goslim_pir synonym: "LPS transport" EXACT [] is_a: GO:0006869 ! lipid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015921 name: lipopolysaccharide export namespace: biological_process def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai] synonym: "LPS export" EXACT [] is_a: GO:0015920 ! lipopolysaccharide transport [Term] id: GO:0015922 name: aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.1, EC:1.4.3.16] is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0015923 name: mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015924 name: mannosyl-oligosaccharide mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] xref: EC:3.2.1 is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0015925 name: galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015926 name: glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015927 name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] xref: MetaCyc:TREHALA-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015928 name: fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015929 name: hexosaminidase activity namespace: molecular_function def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544] xref: MetaCyc:3.2.1.52-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015930 name: glutamate synthase activity namespace: molecular_function def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015932 name: nucleobase-containing compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0015933 name: obsolete flavin-containing electron transporter namespace: molecular_function def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd] comment: This term was made obsolete because it does not describe a molecular function. synonym: "flavin-containing electron transporter" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015934 name: large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] synonym: "ribosomal large subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit [Term] id: GO:0015935 name: small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a ribosome." [GOC:mah] subset: goslim_pir synonym: "ribosomal small subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit [Term] id: GO:0015936 name: coenzyme A metabolic process namespace: biological_process alt_id: GO:0006763 def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA metabolism" EXACT [] synonym: "coenzyme A metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0015937 name: coenzyme A biosynthetic process namespace: biological_process alt_id: GO:0006764 def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA biosynthesis" EXACT [] synonym: "coenzyme A anabolism" EXACT [] synonym: "coenzyme A biosynthesis" EXACT [] synonym: "coenzyme A formation" EXACT [] synonym: "coenzyme A synthesis" EXACT [] xref: MetaCyc:COA-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process [Term] id: GO:0015938 name: coenzyme A catabolic process namespace: biological_process alt_id: GO:0006765 def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA catabolism" EXACT [] synonym: "coenzyme A breakdown" EXACT [] synonym: "coenzyme A catabolism" EXACT [] synonym: "coenzyme A degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process [Term] id: GO:0015939 name: pantothenate metabolic process namespace: biological_process alt_id: GO:0006770 def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate metabolism" EXACT [] synonym: "vitamin B5 metabolic process" EXACT [] synonym: "vitamin B5 metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0015940 name: pantothenate biosynthetic process namespace: biological_process alt_id: GO:0033317 alt_id: GO:0033318 def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate anabolism" EXACT [] synonym: "pantothenate anabolism from 2-oxypantoyl lactone" NARROW [] synonym: "pantothenate anabolism from valine" NARROW [] synonym: "pantothenate biosynthesis" EXACT [] synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" NARROW [] synonym: "pantothenate biosynthesis from valine" NARROW [] synonym: "pantothenate biosynthetic process from 2-dehydropantolactone" NARROW [] synonym: "pantothenate biosynthetic process from 2-oxypantoyl lactone" NARROW [] synonym: "pantothenate biosynthetic process from valine" NARROW [] synonym: "pantothenate formation" EXACT [] synonym: "pantothenate formation from 2-oxypantoyl lactone" NARROW [] synonym: "pantothenate formation from valine" NARROW [] synonym: "pantothenate synthesis" EXACT [] synonym: "pantothenate synthesis from 2-oxypantoyl lactone" NARROW [] synonym: "pantothenate synthesis from valine" NARROW [] synonym: "vitamin B5 biosynthesis" EXACT [] synonym: "vitamin B5 biosynthetic process" EXACT [] xref: MetaCyc:PANTO-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-3961 xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0015941 name: pantothenate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate breakdown" EXACT [] synonym: "pantothenate catabolism" EXACT [] synonym: "pantothenate degradation" EXACT [] synonym: "vitamin B5 catabolic process" EXACT [] synonym: "vitamin B5 catabolism" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0015942 name: formate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0015943 name: formate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate anabolism" EXACT [] synonym: "formate biosynthesis" EXACT [] synonym: "formate formation" EXACT [] synonym: "formate synthesis" EXACT [] synonym: "formic acid biosynthesis" EXACT [] synonym: "formic acid biosynthetic process" EXACT [] is_a: GO:0015942 ! formate metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0015944 name: formate oxidation namespace: biological_process def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881] synonym: "formic acid oxidation" EXACT [] xref: MetaCyc:PWY-1881 is_a: GO:0015942 ! formate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015945 name: methanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732] synonym: "methanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0015946 name: methanol oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY] xref: MetaCyc:CO2FORM-PWY is_a: GO:0015945 ! methanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015947 name: methane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732] synonym: "methane metabolism" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0015948 name: methanogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir synonym: "methane biosynthesis" EXACT [] synonym: "methane biosynthetic process" EXACT [] xref: MIPS_funcat:02.16.15 xref: UM-BBD_pathwayID:meth xref: Wikipedia:Methanogenesis is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015947 ! methane metabolic process is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0043447 ! alkane biosynthetic process [Term] id: GO:0015949 name: nucleobase-containing small molecule interconversion namespace: biological_process def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: goslim_pir xref: MetaCyc:P1-PWY is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0015950 name: purine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0015951 name: purine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015952 name: purine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015953 name: pyrimidine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0015954 name: pyrimidine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015955 name: pyrimidine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015956 name: bis(5'-nucleosidyl) oligophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0015957 name: bis(5'-nucleosidyl) oligophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process [Term] id: GO:0015958 name: bis(5'-nucleosidyl) oligophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process [Term] id: GO:0015959 name: diadenosine polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0015960 name: diadenosine polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate anabolism" EXACT [] synonym: "diadenosine polyphosphate biosynthesis" EXACT [] synonym: "diadenosine polyphosphate formation" EXACT [] synonym: "diadenosine polyphosphate synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015961 name: diadenosine polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate breakdown" EXACT [] synonym: "diadenosine polyphosphate catabolism" EXACT [] synonym: "diadenosine polyphosphate degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015962 name: diadenosine triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015963 name: diadenosine triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate anabolism" EXACT [] synonym: "diadenosine triphosphate biosynthesis" EXACT [] synonym: "diadenosine triphosphate formation" EXACT [] synonym: "diadenosine triphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015964 name: diadenosine triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate breakdown" EXACT [] synonym: "diadenosine triphosphate catabolism" EXACT [] synonym: "diadenosine triphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015965 name: diadenosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015966 name: diadenosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate anabolism" EXACT [] synonym: "diadenosine tetraphosphate biosynthesis" EXACT [] synonym: "diadenosine tetraphosphate formation" EXACT [] synonym: "diadenosine tetraphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015967 name: diadenosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate breakdown" EXACT [] synonym: "diadenosine tetraphosphate catabolism" EXACT [] synonym: "diadenosine tetraphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015968 name: stringent response namespace: biological_process def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471] xref: Wikipedia:Stringent_response is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0015969 name: guanosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT [] synonym: "guanosine tetraphosphate metabolism" EXACT [] xref: MetaCyc:PPGPPMET-PWY is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0015970 name: guanosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine tetraphosphate anabolism" EXACT [] synonym: "guanosine tetraphosphate biosynthesis" EXACT [] synonym: "guanosine tetraphosphate formation" EXACT [] synonym: "guanosine tetraphosphate synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0015971 name: guanosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT [] synonym: "guanosine tetraphosphate breakdown" EXACT [] synonym: "guanosine tetraphosphate catabolism" EXACT [] synonym: "guanosine tetraphosphate degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0015972 name: guanosine pentaphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT [] synonym: "guanosine pentaphosphate metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0015973 name: guanosine pentaphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine pentaphosphate anabolism" EXACT [] synonym: "guanosine pentaphosphate biosynthesis" EXACT [] synonym: "guanosine pentaphosphate formation" EXACT [] synonym: "guanosine pentaphosphate synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0015974 name: guanosine pentaphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT [] synonym: "guanosine pentaphosphate breakdown" EXACT [] synonym: "guanosine pentaphosphate catabolism" EXACT [] synonym: "guanosine pentaphosphate degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0015975 name: energy derivation by oxidation of reduced inorganic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemolithotrophie" EXACT [] synonym: "chemolithotrophy" EXACT [] synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy] xref: MIPS_funcat:02.17 xref: Wikipedia:Lithotrophy is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015976 name: carbon utilization namespace: biological_process alt_id: GO:0015978 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: goslim_chembl subset: goslim_pir synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] synonym: "heterotrophy" EXACT [] xref: MIPS_funcat:01.05.01 xref: Wikipedia:Heterotroph is_a: GO:0008150 ! biological_process relationship: has_part GO:0071702 ! organic substance transport relationship: has_part GO:0071703 ! detection of organic substance relationship: has_part GO:0071704 ! organic substance metabolic process [Term] id: GO:0015977 name: carbon fixation namespace: biological_process def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah] synonym: "autotrophic CO2 fixation" EXACT [] synonym: "autotrophic CO2 fixation pathway" EXACT [] synonym: "autotrophy" EXACT [] synonym: "carbon dioxide fixation" NARROW [] xref: MIPS_funcat:01.05.01.05 xref: Wikipedia:Carbon_fixation is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant xref: MIPS_funcat:02.30 xref: Wikipedia:Photosynthesis is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015981 name: obsolete passive proton transport, down the electrochemical gradient namespace: biological_process def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363] comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products. synonym: "passive proton transport, down the electrochemical gradient" EXACT [] is_obsolete: true consider: GO:1902600 [Term] id: GO:0015982 name: obsolete antiport namespace: biological_process def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "antiport" EXACT [] is_obsolete: true replaced_by: GO:0015297 [Term] id: GO:0015983 name: obsolete symport namespace: biological_process def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "symport" EXACT [] is_obsolete: true replaced_by: GO:0015293 [Term] id: GO:0015984 name: obsolete uniport namespace: biological_process def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "uniport" EXACT [] is_obsolete: true replaced_by: GO:0015292 [Term] id: GO:0015985 name: energy coupled proton transport, down electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] is_a: GO:1902600 ! proton transmembrane transport [Term] id: GO:0015986 name: ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] synonym: "chemiosmosis" BROAD [GOC:rs] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015987 name: GTP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363] is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015988 name: energy coupled proton transmembrane transport, against electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah] is_a: GO:1902600 ! proton transmembrane transport [Term] id: GO:0015989 name: light-driven proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient [Term] id: GO:0015990 name: electron transport coupled proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient [Term] id: GO:0015993 name: obsolete molecular hydrogen transport namespace: biological_process def: "OBSOLETE. The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] comment: The reason for obsoletion is that there molecular hydrogen (H2) diffuses passively through membranes (see https://www.researchgate.net/post/How_molecular_hydrogen_is_transported_through_the_cytoplasmic_membrane_of_Escherichia_coli). is_obsolete: true [Term] id: GO:0015994 name: chlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] synonym: "chlorophyll metabolism" EXACT [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process [Term] id: GO:0015995 name: chlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] synonym: "chlorophyll anabolism" EXACT [] synonym: "chlorophyll biosynthesis" EXACT [] synonym: "chlorophyll formation" EXACT [] synonym: "chlorophyll synthesis" EXACT [] xref: MetaCyc:CHLOROPHYLL-SYN is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0015996 name: chlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl] synonym: "chlorophyll breakdown" EXACT [] synonym: "chlorophyll catabolism" EXACT [] synonym: "chlorophyll degradation" EXACT [] is_a: GO:0006787 ! porphyrin-containing compound catabolic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0015997 name: obsolete ubiquinone biosynthetic process monooxygenase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates biological process information. synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT [] synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT [] synonym: "ubiquinone anabolism monooxygenase activity" EXACT [] synonym: "ubiquinone biosynthetic process monooxygenase activity" EXACT [] synonym: "ubiquinone formation monooxygenase activity" EXACT [] synonym: "ubiquinone synthesis monooxygenase activity" EXACT [] is_obsolete: true [Term] id: GO:0016002 name: sulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [GOC:curators] {comment="RHEA:10547"} synonym: "assimilatory sulfite reductase activity" EXACT [] synonym: "assimilatory-type sulfite reductase activity" EXACT [] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [] synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [] synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] synonym: "sulphite reductase activity" EXACT [] xref: MetaCyc:SULFITE-REDUCTASE-RXN xref: RHEA:10547 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016004 name: phospholipase activator activity namespace: molecular_function def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] is_a: GO:0060229 ! lipase activator activity relationship: positively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0016005 name: phospholipase A2 activator activity namespace: molecular_function def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0016004 ! phospholipase activator activity relationship: positively_regulates GO:0004623 ! phospholipase A2 activity [Term] id: GO:0016006 name: Nebenkern namespace: cellular_component def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016007 name: mitochondrial derivative namespace: cellular_component def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016008 name: major mitochondrial derivative namespace: cellular_component def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016009 name: minor mitochondrial derivative namespace: cellular_component def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016010 name: dystrophin-associated glycoprotein complex namespace: cellular_component def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609] subset: goslim_pir synonym: "DGC" EXACT [] synonym: "dystrophin glycoprotein complex" EXACT [] is_a: GO:0090665 ! glycoprotein complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0016011 name: dystroglycan complex namespace: cellular_component def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016012 name: sarcoglycan complex namespace: cellular_component def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] synonym: "sarcoglycan-sarcospan complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016011 ! dystroglycan complex [Term] id: GO:0016013 name: syntrophin complex namespace: cellular_component def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016014 name: dystrobrevin complex namespace: cellular_component def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016015 name: morphogen activity namespace: molecular_function def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0016016 name: obsolete short-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "short-wave-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0016018 name: cyclosporin A binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] synonym: "cyclophilin" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0016019 name: peptidoglycan immune receptor activity namespace: molecular_function def: "Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response." [PMID:14698226] comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. synonym: "peptidoglycan receptor activity" BROAD [] synonym: "peptidoglycan recognition activity" NARROW [] is_a: GO:0038187 ! pattern recognition receptor activity relationship: has_part GO:0042834 ! peptidoglycan binding [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Biological_membrane is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0016021 name: integral component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_chembl synonym: "integral to membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] xref: Wikipedia:Transmembrane_protein is_a: GO:0031224 ! intrinsic component of membrane [Term] id: GO:0016024 name: CDP-diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:24533860] synonym: "CDP-diacylglycerol anabolism" EXACT [] synonym: "CDP-diacylglycerol biosynthesis" EXACT [] synonym: "CDP-diacylglycerol formation" EXACT [] synonym: "CDP-diacylglycerol synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0016025 name: obsolete proteasome endopeptidase regulator namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "proteasome endopeptidase regulator" EXACT [] is_obsolete: true consider: GO:0004175 [Term] id: GO:0016026 name: obsolete proteasome endopeptidase core namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "proteasome endopeptidase core" EXACT [] is_obsolete: true consider: GO:0004175 [Term] id: GO:0016027 name: inaD signaling complex namespace: cellular_component def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] synonym: "inaD signalling complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016028 ! rhabdomere relationship: part_of GO:0019897 ! extrinsic component of plasma membrane [Term] id: GO:0016028 name: rhabdomere namespace: cellular_component def: "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] subset: goslim_pir is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0016029 name: subrhabdomeral cisterna namespace: cellular_component def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] synonym: "SMC" RELATED [] synonym: "submicrovillar cisterna" EXACT [PMID:11707492] is_a: GO:0098827 ! endoplasmic reticulum subcompartment is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0016031 name: tRNA import into mitochondrion namespace: biological_process def: "The process in which a tRNA is transported from the cytosol, into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736] synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf] synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] synonym: "mitochondrial import of cytoplasmic tRNA" NARROW [] synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0035927 ! RNA import into mitochondrion is_a: GO:0051031 ! tRNA transport [Term] id: GO:0016032 name: viral process namespace: biological_process alt_id: GO:0022415 def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. subset: goslim_metagenomics subset: goslim_pir synonym: "viral infection" RELATED [] synonym: "virulence" RELATED [] synonym: "virus process" EXACT [GOC:bf, GOC:jl] xref: Wikipedia:Viral_life_cycle is_a: GO:0044403 ! symbiotic process [Term] id: GO:0016034 name: maleylacetoacetate isomerase activity namespace: molecular_function alt_id: GO:0018841 def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2] xref: EC:5.2.1.2 xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN xref: Reactome:R-HSA-71173 "maleylacetoacetate => fumarylacetoacetate" xref: RHEA:14817 xref: UM-BBD_reactionID:r0106 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0016035 name: zeta DNA polymerase complex namespace: cellular_component def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] is_a: GO:0042575 ! DNA polymerase complex relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0016036 name: cellular response to phosphate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0016037 name: light absorption namespace: biological_process def: "The reception of a photon by a cell." [GOC:go_curators] synonym: "absorption of light" EXACT [] xref: MIPS_funcat:02.45.03 is_a: GO:0009987 ! cellular process relationship: part_of GO:0009583 ! detection of light stimulus [Term] id: GO:0016038 name: absorption of visible light namespace: biological_process def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732] is_a: GO:0016037 ! light absorption [Term] id: GO:0016039 name: absorption of UV light namespace: biological_process def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732] is_a: GO:0016037 ! light absorption [Term] id: GO:0016040 name: glutamate synthase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13753] synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14] synonym: "GOGAT activity" BROAD [] synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14] synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH: GOGAT" EXACT [EC:1.4.1.14] xref: EC:1.4.1.14 xref: KEGG_REACTION:R00093 xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN xref: RHEA:13753 is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor [Term] id: GO:0016041 name: glutamate synthase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1] synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1] synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1] xref: EC:1.4.7.1 xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN xref: MetaCyc:PWY-4341 is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 alt_id: GO:0044240 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: MIPS_funcat:01.06.04 xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] xref: MIPS_funcat:42 is_a: GO:0009987 ! cellular process is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016045 name: detection of bacterium namespace: biological_process alt_id: GO:0009598 alt_id: GO:0009681 def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb] synonym: "detection of bacteria" EXACT [] synonym: "perception of bacteria" RELATED [] synonym: "perception of bacterium" RELATED [] is_a: GO:0009617 ! response to bacterium is_a: GO:0098543 ! detection of other organism [Term] id: GO:0016046 name: detection of fungus namespace: biological_process alt_id: GO:0009599 alt_id: GO:0016047 def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb] synonym: "detection of fungi" EXACT [] synonym: "detection of parasitic fungi" NARROW [] synonym: "detection of parasitic fungus" NARROW [] synonym: "perception of fungi" RELATED [] synonym: "perception of fungus" RELATED [] synonym: "perception of parasitic fungi" NARROW [] synonym: "perception of parasitic fungus" RELATED [] is_a: GO:0009620 ! response to fungus is_a: GO:0098543 ! detection of other organism [Term] id: GO:0016048 name: detection of temperature stimulus namespace: biological_process def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] synonym: "detection of temperature" EXACT [] synonym: "detection of thermal stimulus" EXACT [] synonym: "perception of temperature" RELATED [] xref: MIPS_funcat:34.11.09 is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] xref: MIPS_funcat:40.01 is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process alt_id: GO:0006093 def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] xref: MIPS_funcat:01.05.01.03 is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process alt_id: GO:0006095 alt_id: GO:0044276 alt_id: GO:0044724 def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] xref: MIPS_funcat:01.05.01.01 is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: janelomax creation_date: 2012-10-23T16:34:39Z [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] xref: MIPS_funcat:01.05.01.03.03 is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] xref: MIPS_funcat:01.05.01.01.03 is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0016055 name: Wnt signaling pathway namespace: biological_process alt_id: GO:0007222 def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled signaling pathway" EXACT [] synonym: "frizzled signalling pathway" EXACT [] synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "Wnt receptor signalling pathway" EXACT [] synonym: "Wnt-activated signaling pathway" RELATED [] xref: MIPS_funcat:30.05.02.20 is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0198738 ! cell-cell signaling by wnt [Term] id: GO:0016056 name: rhodopsin mediated signaling pathway namespace: biological_process alt_id: GO:0009586 def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf] synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] synonym: "rhodopsin signaling" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007602 ! phototransduction is_a: GO:0071482 ! cellular response to light stimulus relationship: part_of GO:0007603 ! phototransduction, visible light [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0016058 name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling namespace: biological_process def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "maintenance of rhodopsin mediated signaling" RELATED [] synonym: "maintenance of rhodopsin mediated signalling" EXACT [] is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell [Term] id: GO:0016059 name: deactivation of rhodopsin mediated signaling namespace: biological_process def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] synonym: "deactivation of rhodopsin mediated signalling" EXACT [] synonym: "rod response recovery" BROAD [GOC:bf] is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway [Term] id: GO:0016060 name: metarhodopsin inactivation namespace: biological_process def: "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] is_a: GO:0009968 ! negative regulation of signal transduction relationship: has_part GO:0004703 ! G protein-coupled receptor kinase activity relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling [Term] id: GO:0016061 name: regulation of light-activated channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010461 ! light-activated ion channel activity relationship: regulates GO:0010461 ! light-activated ion channel activity [Term] id: GO:0016062 name: adaptation of rhodopsin mediated signaling namespace: biological_process def: "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] synonym: "adaptation of rhodopsin mediated signalling" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway relationship: part_of GO:0036367 ! light adaption [Term] id: GO:0016063 name: rhodopsin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] synonym: "rhodopsin anabolism" EXACT [] synonym: "rhodopsin biosynthesis" EXACT [] synonym: "rhodopsin formation" EXACT [] synonym: "rhodopsin synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046154 ! rhodopsin metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0016064 name: immunoglobulin mediated immune response namespace: biological_process def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antibody-mediated immune response" EXACT [] xref: MIPS_funcat:36.25.16.03 is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016065 name: obsolete humoral defense mechanism (sensu Protostomia) namespace: biological_process def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid] comment: This term was made obsolete because antibodies are not found in the taxon Protostomia. synonym: "humoral defence mechanism (sensu Protostomia)" EXACT [] synonym: "humoral defense mechanism (sensu Protostomia)" EXACT [] is_obsolete: true [Term] id: GO:0016068 name: type I hypersensitivity namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. synonym: "immediate hypersensitivity response" EXACT [] xref: Wikipedia:Type_I_hypersensitivity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0016071 name: mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pombe synonym: "mRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0016072 name: rRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] subset: goslim_drosophila synonym: "rRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016073 name: snRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pombe synonym: "snRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016074 name: snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] subset: goslim_drosophila subset: goslim_pombe synonym: "snoRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016075 name: rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] synonym: "rRNA breakdown" EXACT [] synonym: "rRNA catabolism" EXACT [] synonym: "rRNA degradation" EXACT [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016076 name: snRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] synonym: "snRNA breakdown" EXACT [] synonym: "snRNA catabolism" EXACT [] synonym: "snRNA degradation" EXACT [] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016077 name: snoRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732] synonym: "snoRNA breakdown" EXACT [] synonym: "snoRNA catabolism" EXACT [] synonym: "snoRNA degradation" EXACT [] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016078 name: tRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai] synonym: "tRNA breakdown" EXACT [] synonym: "tRNA catabolism" EXACT [] synonym: "tRNA degradation" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016079 name: synaptic vesicle exocytosis namespace: biological_process def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] subset: goslim_synapse xref: MIPS_funcat:20.09.16.09.05 is_a: GO:0045055 ! regulated exocytosis is_a: GO:0099003 ! vesicle-mediated transport in synapse is_a: GO:0099643 ! signal release from synapse intersection_of: GO:0045055 ! regulated exocytosis intersection_of: occurs_in GO:0098793 ! presynapse relationship: occurs_in GO:0098793 ! presynapse relationship: part_of GO:0007269 ! neurotransmitter secretion relationship: part_of GO:0099504 ! synaptic vesicle cycle [Term] id: GO:0016080 name: synaptic vesicle targeting namespace: biological_process def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] is_a: GO:0006903 ! vesicle targeting is_a: GO:0140029 ! exocytic process relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016081 name: synaptic vesicle docking namespace: biological_process def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process." [PMID:15217342] comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015). subset: goslim_synapse synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] synonym: "synaptic vesicle docking involved in exocytosis" EXACT [] is_a: GO:0006904 ! vesicle docking involved in exocytosis intersection_of: GO:0006904 ! vesicle docking involved in exocytosis intersection_of: part_of GO:0016079 ! synaptic vesicle exocytosis relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016082 name: synaptic vesicle priming namespace: biological_process def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190] comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015) subset: goslim_synapse is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0140029 ! exocytic process relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016083 name: obsolete synaptic vesicle fusion namespace: biological_process def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle fusion" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016084 name: myostimulatory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016085 name: myoinhibitory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016086 name: obsolete allatostatin namespace: molecular_function def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383] comment: This term was made obsolete because it refers to a gene product. synonym: "allatostatin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045968 [Term] id: GO:0016087 name: ecdysiostatic hormone activity namespace: molecular_function def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0016088 name: obsolete insulin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "insulin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045722 consider: GO:0045727 consider: GO:0045935 consider: GO:0046326 consider: GO:0046889 [Term] id: GO:0016090 name: prenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684] synonym: "prenol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0016091 name: prenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] synonym: "prenol anabolism" EXACT [] synonym: "prenol biosynthesis" EXACT [] synonym: "prenol formation" EXACT [] synonym: "prenol synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0016090 ! prenol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0016092 name: prenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] synonym: "prenol breakdown" EXACT [] synonym: "prenol catabolism" EXACT [] synonym: "prenol degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0016090 ! prenol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0016093 name: polyprenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2, ISBN:0198547684] synonym: "polyprenol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0016094 name: polyprenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] synonym: "polyprenol anabolism" EXACT [] synonym: "polyprenol biosynthesis" EXACT [] synonym: "polyprenol formation" EXACT [] synonym: "polyprenol synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0016095 name: polyprenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] synonym: "polyprenol breakdown" EXACT [] synonym: "polyprenol catabolism" EXACT [] synonym: "polyprenol degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0016098 name: monoterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [ISBN:0198547684] synonym: "monoterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016099 name: monoterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators] synonym: "monoterpenoid anabolism" EXACT [] synonym: "monoterpenoid biosynthesis" EXACT [] synonym: "monoterpenoid formation" EXACT [] synonym: "monoterpenoid synthesis" EXACT [] xref: MetaCyc:PWY-3041 xref: MIPS_funcat:01.06.01.07.03 is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016100 name: monoterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators] synonym: "monoterpenoid breakdown" EXACT [] synonym: "monoterpenoid catabolism" EXACT [] synonym: "monoterpenoid degradation" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016101 name: diterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] synonym: "diterpene metabolic process" NARROW [] synonym: "diterpene metabolism" NARROW [] synonym: "diterpenoid metabolism" EXACT [] xref: MIPS_funcat:01.06.01.07.07 is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016102 name: diterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] synonym: "diterpene biosynthesis" NARROW [] synonym: "diterpene biosynthetic process" NARROW [] synonym: "diterpenoid anabolism" EXACT [] synonym: "diterpenoid biosynthesis" EXACT [] synonym: "diterpenoid formation" EXACT [] synonym: "diterpenoid synthesis" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016103 name: diterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] synonym: "diterpene catabolic process" NARROW [] synonym: "diterpene catabolism" NARROW [] synonym: "diterpenoid breakdown" EXACT [] synonym: "diterpenoid catabolism" EXACT [] synonym: "diterpenoid degradation" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016104 name: triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] synonym: "triterpene biosynthesis" NARROW [] synonym: "triterpene biosynthetic process" NARROW [] synonym: "triterpenoid anabolism" EXACT [] synonym: "triterpenoid biosynthesis" EXACT [] synonym: "triterpenoid formation" EXACT [] synonym: "triterpenoid synthesis" EXACT [] xref: MIPS_funcat:01.06.01.07.09 xref: MIPS_funcat:01.06.01.07.11 is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016105 name: triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] synonym: "triterpene catabolic process" NARROW [] synonym: "triterpene catabolism" NARROW [] synonym: "triterpenoid breakdown" EXACT [] synonym: "triterpenoid catabolism" EXACT [] synonym: "triterpenoid degradation" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] xref: MIPS_funcat:01.06.01.07.05 is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016107 name: sesquiterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid breakdown" EXACT [] synonym: "sesquiterpenoid catabolism" EXACT [] synonym: "sesquiterpenoid degradation" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016108 name: tetraterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684] synonym: "tetraterpene metabolic process" NARROW [] synonym: "tetraterpene metabolism" NARROW [] synonym: "tetraterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016109 name: tetraterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene biosynthesis" NARROW [] synonym: "tetraterpene biosynthetic process" NARROW [] synonym: "tetraterpenoid anabolism" EXACT [] synonym: "tetraterpenoid biosynthesis" EXACT [] synonym: "tetraterpenoid formation" EXACT [] synonym: "tetraterpenoid synthesis" EXACT [] xref: MIPS_funcat:01.06.01.07.13 is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016110 name: tetraterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene catabolic process" NARROW [] synonym: "tetraterpene catabolism" NARROW [] synonym: "tetraterpenoid breakdown" EXACT [] synonym: "tetraterpenoid catabolism" EXACT [] synonym: "tetraterpenoid degradation" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016111 name: polyterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] synonym: "polyterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016112 name: polyterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] synonym: "polyterpenoid anabolism" EXACT [] synonym: "polyterpenoid biosynthesis" EXACT [] synonym: "polyterpenoid formation" EXACT [] synonym: "polyterpenoid synthesis" EXACT [] xref: MIPS_funcat:01.06.01.07.15 is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016113 name: polyterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] synonym: "polyterpenoid breakdown" EXACT [] synonym: "polyterpenoid catabolism" EXACT [] synonym: "polyterpenoid degradation" EXACT [] is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0016115 name: terpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid breakdown" EXACT [] synonym: "terpenoid catabolism" EXACT [] synonym: "terpenoid degradation" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008300 ! isoprenoid catabolic process [Term] id: GO:0016116 name: carotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] synonym: "carotenoid metabolism" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process [Term] id: GO:0016117 name: carotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid anabolism" EXACT [] synonym: "carotenoid biosynthesis" EXACT [] synonym: "carotenoid formation" EXACT [] synonym: "carotenoid synthesis" EXACT [] xref: MetaCyc:CAROTENOID-PWY is_a: GO:0016109 ! tetraterpenoid biosynthetic process is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0016118 name: carotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid breakdown" EXACT [] synonym: "carotenoid catabolism" EXACT [] synonym: "carotenoid degradation" EXACT [] is_a: GO:0016110 ! tetraterpenoid catabolic process is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016119 name: carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] synonym: "carotene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0016120 name: carotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators] synonym: "carotene anabolism" EXACT [] synonym: "carotene biosynthesis" EXACT [] synonym: "carotene formation" EXACT [] synonym: "carotene synthesis" EXACT [] is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0016121 name: carotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators] synonym: "carotene breakdown" EXACT [] synonym: "carotene catabolism" EXACT [] synonym: "carotene degradation" EXACT [] is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0016122 name: xanthophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] synonym: "xanthophyll metabolism" EXACT [] is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016123 name: xanthophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll anabolism" EXACT [] synonym: "xanthophyll biosynthesis" EXACT [] synonym: "xanthophyll formation" EXACT [] synonym: "xanthophyll synthesis" EXACT [] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016124 name: xanthophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll breakdown" EXACT [] synonym: "xanthophyll catabolism" EXACT [] synonym: "xanthophyll degradation" EXACT [] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016125 name: sterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] synonym: "sterol metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0016126 name: sterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] synonym: "sterol anabolism" EXACT [] synonym: "sterol biosynthesis" EXACT [] synonym: "sterol formation" EXACT [] synonym: "sterol synthesis" EXACT [] xref: MetaCyc:PWY-2541 is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016125 ! sterol metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0016127 name: sterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] synonym: "sterol breakdown" EXACT [] synonym: "sterol catabolism" EXACT [] synonym: "sterol degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016125 ! sterol metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0016128 name: phytosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684] synonym: "phytosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0016129 name: phytosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309] synonym: "phytosteroid anabolism" EXACT [] synonym: "phytosteroid biosynthesis" EXACT [] synonym: "phytosteroid formation" EXACT [] synonym: "phytosteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0016130 name: phytosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah] synonym: "phytosteroid breakdown" EXACT [] synonym: "phytosteroid catabolism" EXACT [] synonym: "phytosteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0016131 name: brassinosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid metabolism" EXACT [] is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0016132 name: brassinosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid anabolism" EXACT [] synonym: "brassinosteroid biosynthesis" EXACT [] synonym: "brassinosteroid formation" EXACT [] synonym: "brassinosteroid synthesis" EXACT [] xref: MetaCyc:PWY-2582 xref: MetaCyc:PWY-699 is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0016133 name: brassinosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid breakdown" EXACT [] synonym: "brassinosteroid catabolism" EXACT [] synonym: "brassinosteroid degradation" EXACT [] is_a: GO:0016130 ! phytosteroid catabolic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0016134 name: saponin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684] synonym: "saponin metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0016135 name: saponin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] synonym: "saponin anabolism" EXACT [] synonym: "saponin biosynthesis" EXACT [] synonym: "saponin formation" EXACT [] synonym: "saponin synthesis" EXACT [] is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016138 ! glycoside biosynthetic process [Term] id: GO:0016136 name: saponin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] synonym: "saponin breakdown" EXACT [] synonym: "saponin catabolism" EXACT [] synonym: "saponin degradation" EXACT [] is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016139 ! glycoside catabolic process [Term] id: GO:0016137 name: glycoside metabolic process namespace: biological_process alt_id: GO:0016140 def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684] synonym: "glycoside metabolism" EXACT [] synonym: "O-glycoside metabolic process" EXACT [] synonym: "O-glycoside metabolism" EXACT [] is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0016138 name: glycoside biosynthetic process namespace: biological_process alt_id: GO:0016141 def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] synonym: "glycoside anabolism" EXACT [] synonym: "glycoside biosynthesis" EXACT [] synonym: "glycoside formation" EXACT [] synonym: "glycoside synthesis" EXACT [] synonym: "O-glycoside anabolism" EXACT [] synonym: "O-glycoside biosynthesis" EXACT [] synonym: "O-glycoside biosynthetic process" EXACT [] synonym: "O-glycoside formation" EXACT [] synonym: "O-glycoside synthesis" EXACT [] xref: MIPS_funcat:01.20.01.07 is_a: GO:0016137 ! glycoside metabolic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0016139 name: glycoside catabolic process namespace: biological_process alt_id: GO:0016142 def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] synonym: "glycoside breakdown" EXACT [] synonym: "glycoside catabolism" EXACT [] synonym: "glycoside degradation" EXACT [] synonym: "O-glycoside breakdown" EXACT [] synonym: "O-glycoside catabolic process" EXACT [] synonym: "O-glycoside catabolism" EXACT [] synonym: "O-glycoside degradation" EXACT [] xref: MIPS_funcat:01.05.01.01.01 is_a: GO:0016137 ! glycoside metabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0016143 name: S-glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside metabolism" EXACT [] synonym: "thioglycoside metabolic process" EXACT [] synonym: "thioglycoside metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0016144 name: S-glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside anabolism" EXACT [] synonym: "S-glycoside biosynthesis" EXACT [] synonym: "S-glycoside formation" EXACT [] synonym: "S-glycoside synthesis" EXACT [] synonym: "thioglycoside biosynthesis" EXACT [] synonym: "thioglycoside biosynthetic process" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0016145 name: S-glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside breakdown" EXACT [] synonym: "S-glycoside catabolism" EXACT [] synonym: "S-glycoside degradation" EXACT [] synonym: "thioglycoside catabolic process" EXACT [] synonym: "thioglycoside catabolism" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0016146 name: obsolete protein-synthesizing GTPase activity, initiation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, initiation" EXACT [] is_obsolete: true consider: GO:0003743 consider: GO:0003924 consider: GO:0006412 consider: GO:0006413 [Term] id: GO:0016147 name: obsolete protein-synthesizing GTPase activity, elongation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, elongation" EXACT [] is_obsolete: true consider: GO:0003746 consider: GO:0003924 consider: GO:0006412 consider: GO:0006414 [Term] id: GO:0016148 name: obsolete protein-synthesizing GTPase activity, termination namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, termination" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0006412 consider: GO:0006415 consider: GO:0008079 [Term] id: GO:0016149 name: translation release factor activity, codon specific namespace: molecular_function def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016150 name: translation release factor activity, codon nonspecific namespace: molecular_function def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016151 name: nickel cation binding namespace: molecular_function def: "Interacting selectively and non-covalently with nickel (Ni) cations." [GOC:ai] synonym: "nickel binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0016152 name: mercury (II) reductase activity namespace: molecular_function alt_id: GO:0018692 def: "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [EC:1.16.1.1, RHEA:23856] synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1] synonym: "mer A" RELATED [EC:1.16.1.1] synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1] xref: EC:1.16.1.1 xref: KEGG_REACTION:R02807 xref: MetaCyc:MERCURY-II-REDUCTASE-RXN xref: RHEA:23856 xref: UM-BBD_reactionID:r0406 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0016153 name: urocanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13101] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49] synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49] synonym: "urocanase activity" EXACT [EC:4.2.1.49] xref: EC:4.2.1.49 xref: KEGG_REACTION:R02914 xref: MetaCyc:UROCANATE-HYDRATASE-RXN xref: Reactome:R-HSA-70903 "urocanate + H2O => 4-imidazolone-5-propionate" xref: RHEA:13101 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016154 name: pyrimidine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] synonym: "Py-NPase activity" EXACT [EC:2.4.2.2] synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2] xref: EC:2.4.2.2 xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0016155 name: formyltetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10180] synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] xref: EC:1.5.1.6 xref: KEGG_REACTION:R00941 xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN xref: RHEA:10180 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0016156 name: fumarate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [EC:1.3.1.6, RHEA:18281] synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6] xref: EC:1.3.1.6 xref: KEGG_REACTION:R00402 xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN xref: RHEA:18281 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016157 name: sucrose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] xref: EC:2.4.1.13 xref: MetaCyc:SUCROSE-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016158 name: 3-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] synonym: "1-phytase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] synonym: "phytase activity" BROAD [] synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8] synonym: "phytate 3-phosphatase activity" EXACT [] xref: EC:3.1.3.8 xref: MetaCyc:RXN0-1001 xref: RHEA:16989 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0016159 name: muconolactone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4] synonym: "muconolactone D-isomerase activity" EXACT [] synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4] xref: EC:5.3.3.4 xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN xref: RHEA:12348 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0016160 name: amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016161 name: beta-amylase activity namespace: molecular_function def: "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2] synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2] synonym: "beta amylase activity" EXACT [EC:3.2.1.2] synonym: "glycogenase activity" BROAD [EC:3.2.1.2] synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2] xref: EC:3.2.1.2 xref: MetaCyc:RXN-12279 xref: MetaCyc:RXN-1827 is_a: GO:0016160 ! amylase activity [Term] id: GO:0016162 name: cellulose 1,4-beta-cellobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "avicelase activity" BROAD [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91] synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91] synonym: "CBH 1" RELATED [EC:3.2.1.91] synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91] synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exoglucanase activity" EXACT [EC:3.2.1.91] xref: EC:3.2.1.91 xref: MetaCyc:3.2.1.91-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016163 name: nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] synonym: "iron-iron nitrogenase activity" NARROW [] synonym: "molybdenum-iron nitrogenase activity" NARROW [] synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1] synonym: "vanadium-iron nitrogenase activity" NARROW [] xref: EC:1.18.6.1 xref: MetaCyc:NITROGENASE-RXN xref: UM-BBD_enzymeID:e0395 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0016164 name: obsolete Mo-molybdopterin oxidoreductase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined. synonym: "Mo-molybdopterin oxidoreductase activity" EXACT [] synonym: "molybdopterin oxidoreductase activity" EXACT [] is_obsolete: true replaced_by: GO:0016491 [Term] id: GO:0016165 name: linoleate 13S-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb] synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] synonym: "fat oxidase activity" EXACT [EC:1.13.11.12] synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxydase activity" EXACT [EC:1.13.11.12] synonym: "lipoxygenase activity" BROAD [] xref: EC:1.13.11.12 xref: MetaCyc:LIPOXYGENASE-RXN xref: RHEA:22780 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0016166 name: phytoene dehydrogenase activity namespace: molecular_function def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016167 name: glial cell-derived neurotrophic factor receptor activity namespace: molecular_function def: "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "GDNF receptor activity" EXACT [GOC:mah] synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0016168 name: chlorophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] is_a: GO:0043168 ! anion binding is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0016169 name: bacteriochlorophyll c binding namespace: molecular_function def: "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] is_a: GO:0042314 ! bacteriochlorophyll binding [Term] id: GO:0016170 name: interleukin-15 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-15 receptor." [GOC:ai] synonym: "IL-15" NARROW [] synonym: "interleukin-15 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0016171 name: obsolete cell surface antigen namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "cell surface antigen" EXACT [] is_obsolete: true [Term] id: GO:0016172 name: obsolete antifreeze activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] comment: This term was made obsolete because it refers to a biological process. synonym: "antifreeze activity" EXACT [] is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016173 name: obsolete ice nucleation inhibitor activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai] comment: This term was made obsolete because it refers to a biological process. synonym: "ice nucleation inhibitor activity" EXACT [] is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016174 name: NAD(P)H oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1] synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] synonym: "p138tox" RELATED [EC:1.6.3.1] synonym: "ThOX activity" NARROW [EC:1.6.3.1] synonym: "THOX2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid NADPH oxidase activity" NARROW [] synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] xref: EC:1.6.3.1 xref: Reactome:R-HSA-5693681 "DUOX1,2 reduce O2 to H2O2" is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [Term] id: GO:0016175 name: superoxide-generating NADPH oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] synonym: "cytochrome B-245" RELATED [] xref: EC:1.6.3 xref: Reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen" xref: Reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2" xref: Reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide" xref: Reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen" xref: Reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP" xref: Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen" xref: Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen" xref: Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen" xref: Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-" is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [Term] id: GO:0016176 name: superoxide-generating NADPH oxidase activator activity namespace: molecular_function def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] synonym: "neutrophil cytosol factor 2" NARROW [] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0016175 ! superoxide-generating NADPH oxidase activity [Term] id: GO:0016180 name: snRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0016182 name: synaptic vesicle budding from endosome namespace: biological_process def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709, PMID:24596248] subset: goslim_synapse synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] is_a: GO:0046907 ! intracellular transport is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0070142 ! synaptic vesicle budding is_a: GO:0099003 ! vesicle-mediated transport in synapse relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome [Term] id: GO:0016183 name: synaptic vesicle coating namespace: biological_process def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150] subset: goslim_synapse is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane [Term] id: GO:0016184 name: obsolete synaptic vesicle retrieval namespace: biological_process def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle retrieval" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016185 name: synaptic vesicle budding from presynaptic endocytic zone membrane namespace: biological_process def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150] subset: goslim_synapse synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT [] synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah] is_a: GO:0070142 ! synaptic vesicle budding intersection_of: GO:0070142 ! synaptic vesicle budding intersection_of: part_of GO:0048488 ! synaptic vesicle endocytosis relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016186 name: obsolete synaptic vesicle fission namespace: biological_process def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle fission" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016187 name: obsolete synaptic vesicle internalization namespace: biological_process def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle internalization" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016188 name: synaptic vesicle maturation namespace: biological_process def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709] is_a: GO:0016050 ! vesicle organization is_a: GO:0021700 ! developmental maturation [Term] id: GO:0016189 name: synaptic vesicle to endosome fusion namespace: biological_process def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709] comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. subset: goslim_synapse is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing [Term] id: GO:0016191 name: synaptic vesicle uncoating namespace: biological_process def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248] subset: goslim_synapse synonym: "synaptic vesicle coat depolymerization" EXACT [] synonym: "synaptic vesicle coat protein depolymerization" EXACT [] is_a: GO:0072318 ! clathrin coat disassembly relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] xref: MIPS_funcat:20.09.07 is_a: GO:0006810 ! transport [Term] id: GO:0016197 name: endosomal transport namespace: biological_process alt_id: GO:0032439 def: "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732] subset: goslim_yeast synonym: "endosome localisation" EXACT [GOC:mah] synonym: "endosome localization" RELATED [] synonym: "endosome transport" RELATED [GOC:bf] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0016198 name: axon choice point recognition namespace: biological_process def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0016199 name: axon midline choice point recognition namespace: biological_process def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] is_a: GO:0016198 ! axon choice point recognition [Term] id: GO:0016200 name: synaptic target attraction namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016201 name: synaptic target inhibition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014706 ! striated muscle tissue development relationship: regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0016203 name: muscle attachment namespace: biological_process def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0016204 name: determination of muscle attachment site namespace: biological_process def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0016203 ! muscle attachment [Term] id: GO:0016205 name: selenocysteine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.280, PMID:10026151] xref: EC:2.1.1.280 xref: MetaCyc:RXN-11061 xref: RHEA:26341 is_a: GO:0051995 ! Se-methyltransferase activity [Term] id: GO:0016206 name: catechol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "COMT I" RELATED [EC:2.1.1.6] synonym: "COMT II" RELATED [EC:2.1.1.6] synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] xref: EC:2.1.1.6 xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ" xref: Reactome:R-HSA-8955010 "LRTOMT transfers methyl group from AdoMet to DA, forming 3MT" is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016207 name: 4-coumarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] synonym: "4-coumarate-CoA synthetase activity" EXACT [] synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12] synonym: "4-coumarate:CoA ligase activity" EXACT [] synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4CL" RELATED [EC:6.2.1.12] synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] xref: EC:6.2.1.12 xref: KEGG_REACTION:R01616 xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN xref: RHEA:19641 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0016208 name: AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators] is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding [Term] id: GO:0016209 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: part_of GO:0098869 ! cellular oxidant detoxification relationship: part_of GO:0098869 ! cellular oxidant detoxification [Term] id: GO:0016210 name: naringenin-chalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] synonym: "DOCS" NARROW [] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] xref: EC:2.3.1.74 xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN xref: RHEA:11128 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016211 name: ammonia ligase activity namespace: molecular_function def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] xref: EC:6.3.1 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0016212 name: kynurenine-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine aminotransferase activity" BROAD [EC:2.6.1.7] synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7] synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] xref: EC:2.6.1.7 xref: MetaCyc:2.6.1.7-RXN xref: Reactome:R-HSA-893583 "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate" xref: Reactome:R-HSA-893596 "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu" xref: Reactome:R-HSA-901097 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]" xref: RHEA:20964 is_a: GO:0036137 ! kynurenine aminotransferase activity [Term] id: GO:0016213 name: linoleoyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3] comment: Note that this function was formerly EC:1.14.99.25. synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] synonym: "delta(6)-desaturase activity" BROAD [] synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "fatty acid 6-desaturase activity" BROAD [] synonym: "fatty acid delta(6)-desaturase activity" BROAD [] synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "linoleate desaturase activity" RELATED [] synonym: "linoleic acid desaturase activity" RELATED [] synonym: "linoleic desaturase activity" RELATED [] synonym: "linoleoyl CoA desaturase activity" EXACT [] synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3] synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] xref: EC:1.14.19.3 xref: MetaCyc:1.14.19.3-RXN xref: Reactome:R-HSA-2046084 "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA" xref: Reactome:R-HSA-2046096 "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA" xref: Reactome:R-HSA-2046097 "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA" xref: Reactome:R-HSA-2046099 "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA" xref: RHEA:22196 is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0016215 name: acyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.1, EC:1.14.19.5, GOC:mah] synonym: "CoA desaturase activity" BROAD [] xref: EC:1.14.19 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0016216 name: isopenicillin-N synthase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22428] synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1] synonym: "isopenicillin-N synthetase activity" EXACT [] synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1] xref: EC:1.21.3.1 xref: KEGG_REACTION:R04872 xref: MetaCyc:1.21.3.1-RXN xref: RHEA:22428 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0016217 name: N-ethylammeline chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN] xref: MetaCyc:R465-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0016218 name: obsolete polyketide synthase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because the activity it describes does not exist, and the gene product with the name 'polyketide synthase' has multiple functional domains, so using the name to describe a single function would be misleading. synonym: "polyketide synthase activity" EXACT [] is_obsolete: true replaced_by: GO:0030639 consider: GO:0034081 [Term] id: GO:0016222 name: procollagen-proline 4-dioxygenase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" EXACT [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0016223 name: beta-alanine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] xref: EC:2.6.1.18 xref: MetaCyc:2.6.1.18-RXN xref: Reactome:R-HSA-909776 "beta-alanine + pyruvate => 3-oxopropanoate + alanine" xref: RHEA:14077 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0016226 name: iron-sulfur cluster assembly namespace: biological_process def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] subset: goslim_metagenomics synonym: "iron-sulfur cluster biosynthesis" RELATED [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0031163 ! metallo-sulfur cluster assembly is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0016227 name: obsolete tRNA sulfurtransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] synonym: "tRNA sulfurtransferase activity" EXACT [] synonym: "tRNA sulphurtransferase activity" EXACT [] xref: EC:2.8.1.4 xref: MetaCyc:TRNA-S-TRANSFERASE-RXN is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0016229 name: steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] xref: EC:1.1.1 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016230 name: sphingomyelin phosphodiesterase activator activity namespace: molecular_function def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] synonym: "neutral sphingomyelinase activator" EXACT [] is_a: GO:0016004 ! phospholipase activator activity relationship: positively_regulates GO:0004767 ! sphingomyelin phosphodiesterase activity [Term] id: GO:0016231 name: beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0016232 name: HNK-1 sulfotransferase activity namespace: molecular_function def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973] synonym: "HNK-1 sulphotransferase activity" EXACT [] xref: Reactome:R-HSA-6786048 "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0016233 name: telomere capping namespace: biological_process def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] synonym: "telomere end protection" EXACT [] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0016234 name: inclusion body namespace: cellular_component def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] synonym: "cellular inclusion" RELATED [NIF_Subcellular:sao120573470] synonym: "neuronal cytoplasmic inclusion" NARROW [] xref: NIF_Subcellular:sao120573470 xref: Wikipedia:Inclusion_bodies is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0016235 name: aggresome namespace: cellular_component def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] xref: Wikipedia:Aggresome is_a: GO:0016234 ! inclusion body [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. synonym: "autophagy" BROAD [] is_a: GO:0006914 ! autophagy [Term] id: GO:0016237 name: lysosomal microautophagy namespace: biological_process def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964] is_a: GO:0006914 ! autophagy [Term] id: GO:0016239 name: positive regulation of macroautophagy namespace: biological_process def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] synonym: "activation of macroautophagy" NARROW [] synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "stimulation of macroautophagy" NARROW [] synonym: "up regulation of macroautophagy" EXACT [] synonym: "up-regulation of macroautophagy" EXACT [] synonym: "upregulation of macroautophagy" EXACT [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016236 ! macroautophagy relationship: positively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016240 name: autophagosome membrane docking namespace: biological_process def: "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah] synonym: "autophagic vacuole docking" EXACT [GOC:autophagy] is_a: GO:0140056 ! organelle localization by membrane tethering intersection_of: GO:0140056 ! organelle localization by membrane tethering intersection_of: part_of GO:0097352 ! autophagosome maturation relationship: part_of GO:0097352 ! autophagosome maturation [Term] id: GO:0016241 name: regulation of macroautophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016236 ! macroautophagy relationship: regulates GO:0016236 ! macroautophagy [Term] id: GO:0016242 name: negative regulation of macroautophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] synonym: "down regulation of macroautophagy" EXACT [] synonym: "down-regulation of macroautophagy" EXACT [] synonym: "downregulation of macroautophagy" EXACT [] synonym: "inhibition of macroautophagy" NARROW [] synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016236 ! macroautophagy relationship: negatively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016243 name: regulation of autophagosome size namespace: biological_process def: "Any process that modulates the size of the autophagosome." [GOC:autophagy, GOC:krc] synonym: "regulation of autophagic vacuole size" EXACT [GOC:autophagy] is_a: GO:0032535 ! regulation of cellular component size is_a: GO:1905037 ! autophagosome organization [Term] id: GO:0016246 name: RNA interference namespace: biological_process def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] synonym: "RNAi" EXACT [] xref: Wikipedia:RNA_interference is_a: GO:0035194 ! posttranscriptional gene silencing by RNA [Term] id: GO:0016247 name: channel regulator activity namespace: molecular_function def: "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0016248 name: channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a channel via direct interaction with the channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity relationship: negatively_regulates GO:0015267 ! channel activity [Term] id: GO:0016250 name: N-sulfoglucosamine sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1] synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1] synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1] synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "sulphamidase activity" EXACT [EC:3.10.1.1] xref: EC:3.10.1.1 xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN xref: Reactome:R-HSA-1678708 "SGSH hydrolyses Heparan sulfate chain(2)" xref: Reactome:R-HSA-2090043 "SGSH hydrolyses Heparan sulfate chain(7)" xref: Reactome:R-HSA-2263444 "Defective SGSH does not hydrolyse Heparan sulfate chain(7)" xref: Reactome:R-HSA-9036050 "Defective SGSH does not hydrolyse Heparan sulfate chain(2)" xref: RHEA:17881 is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0016251 name: RNA polymerase II general transcription initiation factor activity namespace: molecular_function alt_id: GO:0000983 alt_id: GO:0001075 alt_id: GO:0003703 def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP)." [GOC:txnOH-2018, PMID:10384286, PMID:25693126] comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur. synonym: "basal RNA polymerase II transcription factor activity" EXACT [] synonym: "general RNA polymerase II transcription factor activity" EXACT [] synonym: "GTF2 activity" EXACT [] synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED [] synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED [] synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED [] synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED [] synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED [] is_a: GO:0140223 ! general transcription initiation factor activity relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0016252 name: obsolete nonspecific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "nonspecific RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0006366 consider: GO:0016251 [Term] id: GO:0016254 name: preassembly of GPI anchor in ER membrane namespace: biological_process def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595] synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016255 name: attachment of GPI anchor to protein namespace: biological_process def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016256 name: N-glycan processing to lysosome namespace: biological_process def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing intersection_of: GO:0006491 ! N-glycan processing intersection_of: part_of GO:0006622 ! protein targeting to lysosome relationship: part_of GO:0006622 ! protein targeting to lysosome [Term] id: GO:0016257 name: N-glycan processing to secreted and cell-surface N-glycans namespace: biological_process def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016258 name: N-glycan diversification namespace: biological_process def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016259 name: selenocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0016260 name: selenocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine anabolism" EXACT [] synonym: "selenocysteine biosynthesis" EXACT [] synonym: "selenocysteine formation" EXACT [] synonym: "selenocysteine synthesis" EXACT [] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0016259 ! selenocysteine metabolic process [Term] id: GO:0016261 name: selenocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine breakdown" EXACT [] synonym: "selenocysteine catabolism" EXACT [] synonym: "selenocysteine degradation" EXACT [] is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0016259 ! selenocysteine metabolic process [Term] id: GO:0016262 name: protein N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0016253 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94] synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.94 xref: MetaCyc:2.4.1.94-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016263 name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] synonym: "Core 1 GalT" RELATED [] synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122] xref: EC:2.4.1.122 xref: MetaCyc:2.4.1.122-RXN xref: Reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)" xref: Reactome:R-HSA-6785524 "Defective C1GALT1C1 does not bind C1GALT1" is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0016264 name: gap junction assembly namespace: biological_process def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363] is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0016265 name: obsolete death namespace: biological_process def: "OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. xref: Wikipedia:Death is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0016266 name: O-glycan processing namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0006493 ! protein O-linked glycosylation [Term] id: GO:0016267 name: O-glycan processing, core 1 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016268 name: O-glycan processing, core 2 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016269 name: O-glycan processing, core 3 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016270 name: O-glycan processing, core 4 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016271 name: obsolete tissue death namespace: biological_process def: "OBSOLETE. A permanent cessation of all vital functions of a tissue." [GOC:dph, GOC:mtg_apoptosis] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0016272 name: prefoldin complex namespace: cellular_component def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] synonym: "GIM complex" NARROW [] xref: Wikipedia:Prefoldin is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0016273 name: arginine N-methyltransferase activity namespace: molecular_function def: "Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016274 name: protein-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636] synonym: "PRMT activity" EXACT [] xref: Reactome:R-HSA-191790 "Loading and methylation of Sm proteins onto SMN Complexes" xref: Reactome:R-HSA-5205798 "PRMT1,PRMT6 methylate arginine-4 of histone H4" xref: Reactome:R-HSA-5205820 "PRMT6 methylates arginine-4 of histone H2A (H2AR3)" xref: Reactome:R-HSA-5205822 "CARM1 methylates arginine-18 (H3R17) of histone H3" xref: Reactome:R-HSA-5205824 "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)" xref: Reactome:R-HSA-5205867 "PRMT1 methylates arginine-12 of histone H2A (H2AR11)" xref: Reactome:R-HSA-5218952 "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)" xref: Reactome:R-HSA-5229010 "CARM1 methylates arginine-27 of histone H3 (H3R26)" xref: Reactome:R-HSA-5229203 "PRMT6 methylates histone H2A arginine-30 (H2AR29)" xref: Reactome:R-HSA-5661126 "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4" xref: Reactome:R-HSA-8879123 "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2" xref: Reactome:R-HSA-8934735 "PRMT1 arginine-methylates RUNX1" is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016273 ! arginine N-methyltransferase activity relationship: part_of GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0016275 name: [cytochrome c]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] xref: EC:2.1.1.124 xref: MetaCyc:2.1.1.124-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016277 name: [myelin basic protein]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [PMID:6177833] synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126] synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126] is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016278 name: lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] xref: Reactome:R-HSA-3222237 "SMYD2 methylates TP53" xref: Reactome:R-HSA-6805730 "SETD9 methylates TP53" xref: Reactome:R-HSA-6805740 "SETD8 methylates TP53" xref: Reactome:R-HSA-6805755 "EHMT1:EHMT2 dimethylates TP53" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016279 name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] xref: Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27" xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex" xref: Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB" xref: Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A" xref: Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8" xref: Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2" xref: Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN" xref: Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP" xref: Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1" is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016278 ! lysine N-methyltransferase activity relationship: part_of GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0016281 name: eukaryotic translation initiation factor 4F complex namespace: cellular_component def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919] synonym: "eIF-4F" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0016282 name: eukaryotic 43S preinitiation complex namespace: cellular_component def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 43S pre-initiation complex" EXACT [] is_a: GO:0070993 ! translation preinitiation complex relationship: has_part GO:0022627 ! cytosolic small ribosomal subunit [Term] id: GO:0016284 name: obsolete alanine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "alanine aminopeptidase activity" EXACT [] xref: EC:3.4.11 is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0016285 name: obsolete cytosol alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] comment: This term was made obsolete because it represents a gene product and refers to cellular component information. synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14] synonym: "arylamidase activity" NARROW [EC:3.4.11.14] synonym: "cytosol alanyl aminopeptidase activity" EXACT [] synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14] synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14] xref: EC:3.4.11.14 xref: MetaCyc:3.4.11.14-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0016286 name: small conductance calcium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "SK calcium-activated potassium channel activity" EXACT [] synonym: "SK KCa channels" EXACT [] synonym: "small conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0016287 name: glycerone-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17657] synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42] synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42] xref: EC:2.3.1.42 xref: KEGG_REACTION:R01013 xref: MetaCyc:2.3.1.42-RXN xref: Reactome:R-HSA-1483002 "DHAP is converted to 1-acyl GO3P by GNPAT" xref: Reactome:R-HSA-75879 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH" xref: RHEA:17657 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0016289 name: CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] xref: Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH" xref: Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT" is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016290 name: palmitoyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0016293 def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] subset: goslim_chembl synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD [] synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] xref: EC:3.1.2.2 xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN xref: MetaCyc:PWY-5148 xref: RHEA:16645 is_a: GO:0047617 ! acyl-CoA hydrolase activity [Term] id: GO:0016295 name: myristoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727] synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "myristoyl-ACP hydrolase activity" EXACT [] synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG_REACTION:R08159 xref: MetaCyc:RXN-10727 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016296 name: palmitoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549] synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "palmitoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG_REACTION:R08162 xref: MetaCyc:RXN-9549 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016297 name: acyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function alt_id: GO:0010281 def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902] synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "acyl-ACP hydrolase activity" EXACT [] synonym: "acyl-ACP thioesterase activity" EXACT [] synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:RXN-7902 xref: Reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila xref: EC:3.1.1 xref: Reactome:R-HSA-163402 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid" xref: Reactome:R-HSA-163432 "cholesterol ester + H2O -> cholesterol + fatty acid" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016299 name: obsolete regulator of G-protein signaling activity namespace: molecular_function def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators] comment: This term was made obsolete because it refers to a combination of a function and a process. synonym: "regulator of G protein signaling activity" EXACT [] synonym: "regulator of G protein signalling activity" EXACT [] synonym: "regulator of G-protein signaling activity" EXACT [] synonym: "regulator of G-protein signalling activity" EXACT [] synonym: "RGS" EXACT [] is_obsolete: true consider: GO:0005095 consider: GO:0034260 consider: GO:0045744 [Term] id: GO:0016300 name: tRNA (uracil) methyltransferase activity namespace: molecular_function alt_id: GO:0016431 def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). synonym: "tRNA (uridine) methyltransferase activity" EXACT [] is_a: GO:0008175 ! tRNA methyltransferase activity [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: part_of GO:0016310 ! phosphorylation [Term] id: GO:0016303 name: 1-phosphatidylinositol-3-kinase activity namespace: molecular_function alt_id: GO:0004429 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12709] synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137] synonym: "PI3K" EXACT [] synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137] synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] synonym: "Vps34p" RELATED [EC:2.7.1.137] xref: EC:2.7.1.137 xref: KEGG_REACTION:R03362 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN xref: Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3" xref: Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane" xref: Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane" xref: Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane" xref: Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns" xref: Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P" xref: RHEA:12709 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity is_a: GO:0052742 ! phosphatidylinositol kinase activity relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process [Term] id: GO:0016304 name: obsolete phosphatidylinositol 3-kinase activity, class I namespace: molecular_function def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class I" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0016305 name: obsolete phosphatidylinositol 3-kinase activity, class II namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class II" EXACT [] synonym: "PI3KC2" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0016306 name: obsolete phosphatidylinositol 3-kinase activity, class III namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class III" EXACT [] is_obsolete: true replaced_by: GO:0016303 [Term] id: GO:0016307 name: phosphatidylinositol phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation [Term] id: GO:0016308 name: 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: molecular_function alt_id: GO:0004431 alt_id: GO:0045215 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14425] synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68] synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68] synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] synonym: "PIP5K" EXACT [] synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68] synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] xref: EC:2.7.1.68 xref: KEGG_REACTION:R03469 xref: MetaCyc:2.7.1.68-RXN xref: Reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane" xref: Reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2" xref: Reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2" xref: RHEA:14425 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016309 name: 1-phosphatidylinositol-5-phosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149] synonym: "PIP4K" EXACT [] synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] xref: EC:2.7.1.149 xref: MetaCyc:2.7.1.149-RXN xref: Reactome:R-HSA-1675776 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane" xref: Reactome:R-HSA-6811522 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus" xref: RHEA:12280 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016311 name: dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] xref: Wikipedia:Dephosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016312 name: inositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb] xref: Reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7" xref: Reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9" is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0016313 name: obsolete inositol-1,4,5-trisphosphate phosphatase namespace: molecular_function def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb] comment: This term was made obsolete because it is a redundant grouping term with only one child. synonym: "inositol-1,4,5-trisphosphate phosphatase" EXACT [] is_obsolete: true consider: GO:0046030 [Term] id: GO:0016314 name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "MMAC1" RELATED [EC:3.1.3.67] synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "PI(3)P 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PI(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PtdIns(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] xref: EC:3.1.3.67 xref: MetaCyc:3.1.3.67-RXN xref: Reactome:R-HSA-199456 "PTEN dephosphorylates PIP3" xref: Reactome:R-HSA-202237 "Hydrolysis of PIP3 to PI(3,4)P2" xref: Reactome:R-HSA-2317387 "PTEN cancer mutants do not dephosphorylate PIP3" xref: RHEA:25017 is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity [Term] id: GO:0016316 name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function alt_id: GO:0004440 def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] xref: EC:3.1.3.66 xref: MetaCyc:3.1.3.66-RXN xref: Reactome:R-HSA-1676162 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane" xref: Reactome:R-HSA-1676164 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane" is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process [Term] id: GO:0016318 name: ommatidial rotation namespace: biological_process def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity [Term] id: GO:0016319 name: mushroom body development namespace: biological_process def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0016320 name: endoplasmic reticulum membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid] synonym: "ER membrane fusion" EXACT [] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0016322 name: neuron remodeling namespace: biological_process def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091] synonym: "neuronal remodeling" EXACT [] is_a: GO:0042551 ! neuron maturation [Term] id: GO:0016323 name: basolateral plasma membrane namespace: cellular_component def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0098590 ! plasma membrane region [Term] id: GO:0016324 name: apical plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process alt_id: GO:0048130 def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0016326 name: obsolete kinesin motor activity namespace: molecular_function def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb] comment: This term was made obsolete because it represents a gene product. synonym: "kinesin motor activity" EXACT [] is_obsolete: true replaced_by: GO:0003777 [Term] id: GO:0016327 name: apicolateral plasma membrane namespace: cellular_component def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] synonym: "apical lateral plasma membrane" EXACT [PMID:24496625] is_a: GO:0098590 ! plasma membrane region [Term] id: GO:0016328 name: lateral plasma membrane namespace: cellular_component def: "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0016329 name: obsolete apoptosis regulator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0042981 [Term] id: GO:0016330 name: second mitotic wave involved in compound eye morphogenesis namespace: biological_process def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0000278 ! mitotic cell cycle relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016332 name: establishment or maintenance of polarity of embryonic epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0016333 name: morphogenesis of follicular epithelium namespace: biological_process def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0016334 name: establishment or maintenance of polarity of follicular epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium [Term] id: GO:0016335 name: morphogenesis of larval imaginal disc epithelium namespace: biological_process def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002168 ! instar larval development relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0016336 name: establishment or maintenance of polarity of larval imaginal disc epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium [Term] id: GO:0016338 name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0016339 name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-dependent cell adhesion molecule activity" RELATED [] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0016340 name: calcium-dependent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0016341 name: obsolete other collagen namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "other collagen" EXACT [] is_obsolete: true replaced_by: GO:0005581 [Term] id: GO:0016342 name: catenin complex namespace: cellular_component def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0019897 ! extrinsic component of plasma membrane [Term] id: GO:0016343 name: obsolete cytoskeletal anchoring activity namespace: molecular_function def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] comment: This term was made obsolete because it represents a biological process. synonym: "cytoskeletal anchoring activity" EXACT [] is_obsolete: true replaced_by: GO:0007016 [Term] id: GO:0016344 name: meiotic chromosome movement towards spindle pole namespace: biological_process def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] synonym: "chromosome migration to spindle pole during meiosis" EXACT [] synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] synonym: "meiotic chromosome movement" BROAD [] synonym: "meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0051305 ! chromosome movement towards spindle pole is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051305 ! chromosome movement towards spindle pole intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0016345 name: female meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] synonym: "female meiotic chromosome movement" BROAD [] synonym: "female meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0051305 ! chromosome movement towards spindle pole intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0016321 ! female meiosis chromosome segregation [Term] id: GO:0016346 name: male meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] synonym: "male meiotic chromosome movement" BROAD [] synonym: "male meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0051305 ! chromosome movement towards spindle pole intersection_of: part_of GO:0007140 ! male meiotic nuclear division relationship: part_of GO:0007060 ! male meiosis chromosome segregation [Term] id: GO:0016347 name: obsolete calcium-independent cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "calcium-independent cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0007161 consider: GO:0016021 consider: GO:0016338 [Term] id: GO:0016348 name: imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0036011 ! imaginal disc-derived leg segmentation [Term] id: GO:0016351 name: obsolete drug susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "drug susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0016352 name: obsolete insecticide susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "insecticide susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0016353 name: obsolete carbamate susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "carbamate susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0016354 name: obsolete cyclodiene susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "cyclodiene susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0016355 name: obsolete DDT susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "DDT susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0016356 name: obsolete organophosphorus susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "organophosphorus susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0016357 name: obsolete pyrethroid susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "pyrethroid susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0016358 name: dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0031175 ! neuron projection development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0016360 name: sensory organ precursor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph] is_a: GO:0060582 ! cell fate determination involved in pattern specification relationship: part_of GO:0008052 ! sensory organ boundary specification [Term] id: GO:0016361 name: activin receptor activity, type I namespace: molecular_function def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] synonym: "type I activin receptor activity" EXACT [] is_a: GO:0017002 ! activin-activated receptor activity [Term] id: GO:0016362 name: activin receptor activity, type II namespace: molecular_function def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651] synonym: "type II activin receptor activity" EXACT [] xref: Reactome:R-HSA-201443 "Type II receptor phosphorylates type I receptor" is_a: GO:0017002 ! activin-activated receptor activity [Term] id: GO:0016363 name: nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] synonym: "nucleoskeleton" EXACT [] xref: MIPS_funcat:70.10.06 xref: Wikipedia:Nuclear_matrix is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0016401 name: palmitoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3 is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016402 name: pristanoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3 xref: Reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA" xref: Reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)" is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016403 name: dimethylargininase activity namespace: molecular_function def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] xref: EC:3.5.3.18 xref: MetaCyc:DIMETHYLARGININASE-RXN xref: Reactome:R-HSA-5693373 "DDAH1,2 hydrolyses ADMA to DMA and L-Cit" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016404 name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141] synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] xref: EC:1.1.1.141 xref: MetaCyc:1.1.1.141-RXN xref: Reactome:R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD" xref: Reactome:R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD" xref: Reactome:R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1" xref: Reactome:R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1" xref: RHEA:11876 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016405 name: CoA-ligase activity namespace: molecular_function def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] xref: Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate" xref: Reactome:R-HSA-159567 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate" xref: Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate" xref: Reactome:R-HSA-6798345 "GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA" is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016406 name: carnitine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016407 name: acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] synonym: "acetylase activity" EXACT [] xref: Reactome:R-HSA-5628871 "BRD7 promotes EP300-mediated acetylation of TP53" xref: Reactome:R-HSA-5660660 "p300 acetylates RELA subunit" xref: Reactome:R-HSA-5682044 "KAT5 acetylates ATM at DNA DSBs" xref: Reactome:R-HSA-6792712 "KAT5 acetylates ATM at shortened telomeres" xref: Reactome:R-HSA-6805638 "KAT6A acetylates TP53" xref: Reactome:R-HSA-73736 "Acetylation of SL1" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016408 name: C-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016409 name: palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] xref: Reactome:R-HSA-203567 "palmitoylation of eNOS" xref: Reactome:R-HSA-5686304 "ZDHHC2 transfers PALM from PALM-CoA to CKAP4" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016410 name: N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: Reactome:R-HSA-177160 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016411 name: acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] xref: Reactome:R-HSA-1482647 "2-MAG and DAG are transacylated to TAG by PNPLA2/3" xref: Reactome:R-HSA-1482654 "2-MAG is transacylated to DAG by PNPLA2/3" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016412 name: serine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] xref: EC:2.3.1.30 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016413 name: O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0016414 name: O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016415 ! octanoyltransferase activity [Term] id: GO:0016415 name: octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.181 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016416 name: O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: Reactome:R-HSA-2404137 "LRAT esterifies RBP1:atROL and FACYLs to atREs" xref: Reactome:R-HSA-2453855 "LRAT esterifies RBP1:atROL and FACYLs to atREs" xref: Reactome:R-HSA-2466710 "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs" is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016417 name: S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016418 name: S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.38 is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0016419 name: S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.39 is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0016420 name: malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016421 name: CoA carboxylase activity namespace: molecular_function def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0016422 name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] xref: EC:2.1.1.62 xref: MetaCyc:2.1.1.62-RXN is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0016423 name: tRNA (guanine) methyltransferase activity namespace: molecular_function alt_id: GO:0016424 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators] synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016426 name: tRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [GOC:go-curators] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016427 name: tRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016428 name: tRNA (cytosine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] xref: Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)" xref: Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)" xref: Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)" xref: Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)" xref: Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)" is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity [Term] id: GO:0016429 name: tRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36] xref: Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)" xref: Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58" xref: Reactome:R-HSA-6787594 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9" is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016430 name: tRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] xref: EC:2.1.1.55 xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016432 name: tRNA-uridine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] xref: EC:2.5.1.25 xref: MetaCyc:2.5.1.25-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016433 name: rRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators] is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016434 name: rRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [GOC:go-curators] is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016435 name: rRNA (guanine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [EC:2.1.1.-] is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016436 name: rRNA (uridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [GOC:go-curators] is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016437 name: tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.21] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "CTP:tRNA cytidylyltransferase activity" BROAD [] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] xref: EC:2.7.7.21 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0070567 ! cytidylyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016438 name: tRNA-queuosine beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] xref: EC:2.4.1.110 xref: MetaCyc:2.4.1.110-RXN is_a: GO:0000030 ! mannosyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016441 name: posttranscriptional gene silencing namespace: biological_process def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] synonym: "cosuppression" RELATED [] synonym: "post-transcriptional gene silencing" EXACT [GOC:vw] synonym: "PTGS" EXACT [] synonym: "quelling" EXACT [] xref: Wikipedia:Post_transcriptional_gene_silencing is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0016458 ! gene silencing is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0016442 name: RISC complex namespace: cellular_component alt_id: GO:0035068 def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] synonym: "micro-ribonucleoprotein complex" RELATED [] synonym: "miRNP complex" RELATED [] synonym: "RNA-induced silencing complex" EXACT [] xref: Wikipedia:RNA-induced_silencing_complex is_a: GO:0031332 ! RNAi effector complex [Term] id: GO:0016443 name: bidentate ribonuclease III activity namespace: molecular_function def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] synonym: "bidentate RNase III activity" EXACT [] xref: EC:3.1.26 is_a: GO:0004525 ! ribonuclease III activity [Term] id: GO:0016444 name: somatic cell DNA recombination namespace: biological_process def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0016445 name: somatic diversification of immunoglobulins namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] synonym: "somatic diversification of antibodies" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] synonym: "somatic hypermutation of antibody genes" EXACT [] is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016453 name: C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0016454 name: C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] is_a: GO:0016408 ! C-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016456 name: X chromosome located dosage compensation complex, transcription activating namespace: cellular_component def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mr, GOC:mtg_sensu, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] synonym: "dosage compensation complex" BROAD [] is_a: GO:0046536 ! dosage compensation complex is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0000805 ! X chromosome [Term] id: GO:0016457 name: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl] synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb] is_a: GO:0042714 ! dosage compensation complex assembly is_a: GO:0065004 ! protein-DNA complex assembly intersection_of: GO:0042714 ! dosage compensation complex assembly intersection_of: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome relationship: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome [Term] id: GO:0016458 name: gene silencing namespace: biological_process def: "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] comment: This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class. subset: goslim_drosophila subset: goslim_pir synonym: "long-term maintenance of gene inactivation" NARROW [] xref: Wikipedia:Gene_silencing is_a: GO:0009987 ! cellular process is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0016459 name: myosin complex namespace: cellular_component def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0016460 name: myosin II complex namespace: cellular_component def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin] synonym: "conventional myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016461 name: unconventional myosin complex namespace: cellular_component alt_id: GO:0005860 def: "A portmanteau term for myosins other than myosin II." [GOC:ma] comment: Note that this term is retained because it is widely used by biologists. synonym: "non-muscle myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016463 name: zinc transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)." [EC:7.2.2.12] synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [] synonym: "P(1B)-type ATPase activity" NARROW [EC:7.2.2.12] synonym: "P1B-type ATPase activity" EXACT [EC:7.2.2.12] synonym: "zinc exporting ATPase activity" EXACT [] synonym: "zinc-exporting ATPase activity" RELATED [] synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:7.2.2.12] synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:7.2.2.12] synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:7.2.2.12] synonym: "Zn2+-exporting ATPase activity" EXACT [EC:7.2.2.12] xref: EC:7.2.2.12 xref: MetaCyc:3.6.3.5-RXN xref: RHEA:20621 is_a: GO:0015633 ! ATPase-coupled zinc transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism [Term] id: GO:0016464 name: chloroplast protein-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:7.4.2.4] synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:7.4.2.4] synonym: "chloroplast protein ABC transporter" NARROW [] xref: EC:7.4.2.4 xref: MetaCyc:3.6.3.52-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0016465 name: chaperonin ATPase complex namespace: cellular_component def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] is_a: GO:0101031 ! chaperone complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0016466 name: obsolete hydrogen-translocating A-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1] comment: This term was made obsolete because it represents a gene product. synonym: "hydrogen-translocating A-type ATPase activity" EXACT [] synonym: "proton-translocating A-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0016467 name: obsolete hydrogen-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] synonym: "F1-ATPase activity" EXACT [] synonym: "hydrogen-translocating F-type ATPase activity" EXACT [] synonym: "proton-translocating F-type ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0016468 name: obsolete sodium-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] synonym: "sodium-translocating F-type ATPase activity" EXACT [] is_obsolete: true consider: GO:0046932 consider: GO:0046962 [Term] id: GO:0016469 name: proton-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] subset: goslim_metagenomics subset: goslim_pir synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0016471 name: vacuolar proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] is_a: GO:0033176 ! proton-transporting V-type ATPase complex intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex intersection_of: part_of GO:0005774 ! vacuolar membrane relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0016472 name: sodium ion-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] subset: goslim_pir synonym: "sodium-transporting two-sector ATPase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0016473 name: sodium ion-transporting F-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] synonym: "sodium-translocating F-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016474 name: sodium ion-transporting V-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] synonym: "sodium-translocating V-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016475 name: detection of nuclear:cytoplasmic ratio namespace: biological_process def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl] synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT [] synonym: "sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0016049 ! cell growth [Term] id: GO:0016476 name: regulation of embryonic cell shape namespace: biological_process def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0045995 ! regulation of embryonic development [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] xref: MIPS_funcat:34.05.01 xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility [Term] id: GO:0016479 name: negative regulation of transcription by RNA polymerase I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW [] synonym: "negative regulation of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006360 ! transcription by RNA polymerase I relationship: negatively_regulates GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0016480 name: negative regulation of transcription by RNA polymerase III namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW [] synonym: "negative regulation of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006359 ! regulation of transcription by RNA polymerase III is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006383 ! transcription by RNA polymerase III relationship: negatively_regulates GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0016482 name: cytosolic transport namespace: biological_process def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol [Term] id: GO:0016483 name: tryptophan hydroxylase activator activity namespace: molecular_function def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0004510 ! tryptophan 5-monooxygenase activity [Term] id: GO:0016484 name: obsolete proprotein convertase 2 activator activity namespace: molecular_function def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "proprotein convertase 2 activator activity" EXACT [] is_obsolete: true consider: GO:0016504 [Term] id: GO:0016485 name: protein processing namespace: biological_process alt_id: GO:0051605 def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] xref: MIPS_funcat:14.07.11 xref: MIPS_funcat:18.01.05 is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation [Term] id: GO:0016486 name: peptide hormone processing namespace: biological_process def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016485 ! protein processing is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0016487 name: farnesol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] synonym: "farnesol metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0016488 name: farnesol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] synonym: "farnesol breakdown" EXACT [] synonym: "farnesol catabolism" EXACT [] synonym: "farnesol degradation" EXACT [] is_a: GO:0016095 ! polyprenol catabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0016490 name: structural constituent of peritrophic membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "structural constituent of peritrophic matrix" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" xref: Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated" xref: Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated" xref: Reactome:R-HSA-3095889 "MMACHC reduces Cbl" xref: Reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL" xref: Reactome:R-HSA-5662660 "Dopachrome is transformed to DHICA by DCT" xref: Reactome:R-HSA-8878581 "TYRP1 oxidises DHICA to IQCA" xref: Reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds" xref: Reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" xref: Reactome:R-HSA-9020260 "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5" xref: Reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" xref: Reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0055114 ! oxidation-reduction process [Term] id: GO:0016492 name: G protein-coupled neurotensin receptor activity namespace: molecular_function def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649] synonym: "G protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein coupled neurotensin receptor activity" EXACT [] synonym: "neurotensin receptor activity, G protein coupled" EXACT [] synonym: "neurotensin receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0016493 name: C-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity relationship: has_part GO:0019957 ! C-C chemokine binding [Term] id: GO:0016494 name: C-X-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity relationship: has_part GO:0019958 ! C-X-C chemokine binding [Term] id: GO:0016495 name: C-X3-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling] is_a: GO:0004950 ! chemokine receptor activity relationship: has_part GO:0019960 ! C-X3-C chemokine binding [Term] id: GO:0016496 name: substance P receptor activity namespace: molecular_function def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016497 name: substance K receptor activity namespace: molecular_function def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] synonym: "neurokinin A receptor activity" EXACT [] synonym: "neuromedin L receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016498 name: neuromedin K receptor activity namespace: molecular_function def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] synonym: "neurokinin B receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016499 name: orexin receptor activity namespace: molecular_function def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0016500 name: protein-hormone receptor activity namespace: molecular_function def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0016501 name: prostacyclin receptor activity namespace: molecular_function alt_id: GO:0004959 def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGI receptor activity" RELATED [] synonym: "PGI(2) receptor activity" EXACT [] synonym: "prostaglandin I receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0016502 name: nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0000166 ! nucleotide binding [Term] id: GO:0016503 name: pheromone receptor activity namespace: molecular_function def: "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [GOC:hjd, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: has_part GO:0005550 ! pheromone binding [Term] id: GO:0016504 name: peptidase activator activity namespace: molecular_function def: "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai] synonym: "protease activator activity" NARROW [GOC:mah] xref: MIPS_funcat:18.02.01.01.03 xref: Reactome:R-HSA-168865 "NA activation of TGF-beta" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0061134 ! peptidase regulator activity relationship: part_of GO:0010952 ! positive regulation of peptidase activity relationship: positively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0016505 name: peptidase activator activity involved in apoptotic process namespace: molecular_function def: "Increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptotic protease activator activity" NARROW [] is_a: GO:0016504 ! peptidase activator activity intersection_of: GO:0016504 ! peptidase activator activity intersection_of: part_of GO:0006915 ! apoptotic process relationship: part_of GO:0006915 ! apoptotic process [Term] id: GO:0016506 name: obsolete apoptosis activator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis activator activity" EXACT [] is_obsolete: true replaced_by: GO:0006915 [Term] id: GO:0016507 name: mitochondrial fatty acid beta-oxidation multienzyme complex namespace: cellular_component def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] synonym: "fatty acid beta-oxidation multienzyme complex" BROAD [GOC:imk] synonym: "trifunctional enzyme" RELATED [] is_a: GO:0036125 ! fatty acid beta-oxidation multienzyme complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0036125 ! fatty acid beta-oxidation multienzyme complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0016508 name: long-chain-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [EC:4.2.1.74] synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74] synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74] xref: EC:4.2.1.74 xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN xref: Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA" xref: Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA" xref: Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA" xref: Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA" xref: Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016509 name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [EC:1.1.1.211, GOC:pde] comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "LCHAD" RELATED [EC:1.1.1.211] synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211] xref: EC:1.1.1.211 xref: MetaCyc:1.1.1.211-RXN xref: Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA" is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity [Term] id: GO:0016511 name: obsolete endothelin-converting enzyme activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "endothelin-converting enzyme activity" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016512 name: obsolete endothelin-converting enzyme 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71] comment: This term was made obsolete because it represents a gene product. synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] synonym: "endothelin-converting enzyme 1 activity" EXACT [] xref: EC:3.4.24.71 xref: MetaCyc:3.4.24.71-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016513 name: core-binding factor complex namespace: cellular_component def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254] synonym: "AML1 complex" NARROW [] synonym: "CBF complex" EXACT [] synonym: "PEPB2 complex" NARROW [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0016514 name: SWI/SNF complex namespace: cellular_component def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof." [GOC:bhm, PMID:12672490] synonym: "SWI-SNF complex" EXACT [GOC:mah] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0016515 name: interleukin-13 receptor activity namespace: molecular_function def: "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-13 receptor activity" EXACT [GOC:mah] synonym: "IL-13R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019973 ! interleukin-13 binding relationship: part_of GO:0035772 ! interleukin-13-mediated signaling pathway [Term] id: GO:0016516 name: interleukin-4 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772] synonym: "IL-4 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0016517 name: interleukin-12 receptor activity namespace: molecular_function def: "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-12 receptor activity" EXACT [GOC:mah] synonym: "IL-12R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019972 ! interleukin-12 binding relationship: part_of GO:0035722 ! interleukin-12-mediated signaling pathway [Term] id: GO:0016518 name: interleukin-14 receptor activity namespace: molecular_function def: "Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-14 receptor activity" EXACT [GOC:mah] synonym: "IL-14R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019974 ! interleukin-14 binding [Term] id: GO:0016519 name: gastric inhibitory peptide receptor activity namespace: molecular_function def: "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312] synonym: "GIP receptor activity" EXACT [PMID:19251046] synonym: "glucose-dependent insulinotropic polypeptide receptor activity" EXACT [PMID:19251046] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: part_of GO:0038192 ! gastric inhibitory peptide signaling pathway [Term] id: GO:0016520 name: growth hormone-releasing hormone receptor activity namespace: molecular_function def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0016521 name: pituitary adenylate cyclase activating polypeptide activity namespace: molecular_function def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477] synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016524 name: latrotoxin receptor activity namespace: molecular_function def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961] synonym: "latrophilin" NARROW [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001525 ! angiogenesis relationship: negatively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0016527 name: obsolete brain-specific angiogenesis inhibitor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined. synonym: "brain-specific angiogenesis inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004930 [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm [Term] id: GO:0016529 name: sarcoplasmic reticulum namespace: cellular_component alt_id: GO:0008221 def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0016530 name: metallochaperone activity namespace: molecular_function def: "Directly binding to and delivering metal ions to a target protein." [PMID:11739376] subset: goslim_pir is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0016531 name: copper chaperone activity namespace: molecular_function def: "Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376] is_a: GO:0005507 ! copper ion binding is_a: GO:0016530 ! metallochaperone activity [Term] id: GO:0016532 name: superoxide dismutase copper chaperone activity namespace: molecular_function def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278] comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'. is_a: GO:0008047 ! enzyme activator activity is_a: GO:0016531 ! copper chaperone activity relationship: positively_regulates GO:0004784 ! superoxide dismutase activity [Term] id: GO:0016533 name: protein kinase 5 complex namespace: cellular_component def: "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152] synonym: "cyclin-dependent protein kinase 5 holoenzyme complex" RELATED [] is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0016536 name: obsolete cyclin-dependent protein kinase 5 activator regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] comment: This term was made obsolete because it refers to a specific gene product. synonym: "cyclin-dependent protein kinase 5 activator regulator activity" EXACT [] synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] is_obsolete: true [Term] id: GO:0016538 name: cyclin-dependent protein serine/threonine kinase regulator activity namespace: molecular_function alt_id: GO:0003751 alt_id: GO:0003752 alt_id: GO:0003753 def: "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] synonym: "cyclin" BROAD [] synonym: "cyclin-dependent protein kinase regulator activity" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "G1/S-specific cyclin" NARROW [] synonym: "G2/M-specific cyclin" NARROW [] xref: EC:2.7.1 xref: Reactome:R-HSA-3215385 "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77" is_a: GO:0019887 ! protein kinase regulator activity relationship: part_of GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0016539 name: intein-mediated protein splicing namespace: biological_process def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] synonym: "intein" RELATED [] is_a: GO:0030908 ! protein splicing [Term] id: GO:0016540 name: protein autoprocessing namespace: biological_process def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] subset: goslim_chembl xref: MIPS_funcat:14.07.11.01 is_a: GO:0016485 ! protein processing [Term] id: GO:0016541 name: obsolete intein namespace: molecular_function def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123] comment: This term was made obsolete because it refers to a protein sequence feature. synonym: "intein" EXACT [] is_obsolete: true consider: GO:0004519 consider: GO:0016539 [Term] id: GO:0016543 name: male courtship behavior, orientation prior to leg tapping and wing vibration namespace: biological_process def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827] synonym: "male courtship behavior, orientation" RELATED [] synonym: "male courtship behaviour, orientation" RELATED [] synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016544 name: male courtship behavior, tapping to detect pheromone namespace: biological_process def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, tapping" RELATED [] synonym: "male courtship behaviour, tapping" EXACT [] synonym: "male courtship behaviour, tapping to detect pheromone" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016545 name: male courtship behavior, veined wing vibration namespace: biological_process def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, wing vibration" RELATED [] synonym: "male courtship behaviour, veined wing vibration" EXACT [] synonym: "male courtship behaviour, wing vibration" RELATED [] is_a: GO:0048065 ! male courtship behavior, veined wing extension [Term] id: GO:0016546 name: male courtship behavior, proboscis-mediated licking namespace: biological_process def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, licking" RELATED [] synonym: "male courtship behaviour, licking" RELATED [] synonym: "male courtship behaviour, proboscis-mediated licking" EXACT [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016550 name: obsolete insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "insertion or deletion editing" EXACT [] synonym: "insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016551 name: obsolete posttranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "posttranscriptional insertion or deletion editing" EXACT [] synonym: "posttranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016552 name: obsolete cotranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "cotranscriptional insertion or deletion editing" EXACT [] synonym: "cotranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016553 name: base conversion or substitution editing namespace: biological_process def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837] synonym: "base conversion/substitution editing" EXACT [] is_a: GO:0009451 ! RNA modification [Term] id: GO:0016554 name: cytidine to uridine editing namespace: biological_process def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016555 name: uridine to cytidine editing namespace: biological_process def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016556 name: mRNA modification namespace: biological_process alt_id: GO:0006381 def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb] xref: MIPS_funcat:11.06.03 is_a: GO:0009451 ! RNA modification is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0016557 name: peroxisome membrane biogenesis namespace: biological_process def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016558 name: protein import into peroxisome matrix namespace: biological_process def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772] synonym: "peroxisome matrix protein import" EXACT [] synonym: "protein transport to peroxisome matrix" EXACT [] is_a: GO:0006625 ! protein targeting to peroxisome is_a: GO:0015919 ! peroxisomal membrane transport is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0016559 name: peroxisome fission namespace: biological_process def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] synonym: "peroxisome division" EXACT [] synonym: "peroxisome proliferation" EXACT [] is_a: GO:0048285 ! organelle fission relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016560 name: protein import into peroxisome matrix, docking namespace: biological_process def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507] synonym: "peroxisome matrix protein import, docking" EXACT [] synonym: "peroxisome receptor docking" RELATED [] synonym: "protein docking during peroxisome matrix protein import" EXACT [] synonym: "protein docking during protein import into peroxisome matrix" EXACT [] synonym: "protein docking during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, docking" EXACT [] is_a: GO:0008104 ! protein localization relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016561 name: protein import into peroxisome matrix, translocation namespace: biological_process def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502] synonym: "peroxisome matrix protein import, translocation" EXACT [] synonym: "peroxisome receptor translocation" RELATED [] synonym: "protein translocation during peroxisome matrix protein import" EXACT [] synonym: "protein translocation during protein import into peroxisome matrix" EXACT [] synonym: "protein translocation during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, translocation" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016562 name: protein import into peroxisome matrix, receptor recycling namespace: biological_process def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502] synonym: "peroxisome matrix protein import, receptor recycling" EXACT [] synonym: "peroxisome receptor recycling" RELATED [] synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT [] synonym: "PTS receptor recycling" RELATED [] synonym: "receptor recycling during peroxisome matrix protein import" EXACT [] synonym: "receptor recycling during protein import into peroxisome matrix" EXACT [] synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT [] is_a: GO:0001881 ! receptor recycling intersection_of: GO:0001881 ! receptor recycling intersection_of: part_of GO:0016558 ! protein import into peroxisome matrix relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016563 name: obsolete transcription activator activity namespace: molecular_function alt_id: GO:0003710 def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription activating factor" NARROW [] synonym: "transcription activator activity" EXACT [] synonym: "transcriptional activator activity" EXACT [] xref: MIPS_funcat:11.02.03.04.01 is_obsolete: true replaced_by: GO:0001228 [Term] id: GO:0016564 name: obsolete transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "negative transcriptional regulator activity" EXACT [] synonym: "transcription repressor activity" EXACT [] synonym: "transcriptional repressor activity" EXACT [] xref: MIPS_funcat:11.02.03.04.03 is_obsolete: true consider: GO:0001227 [Term] id: GO:0016565 name: obsolete general transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "general transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0001217 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0016566 name: obsolete specific transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "specific transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0001217 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0016567 name: protein ubiquitination namespace: biological_process def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] synonym: "protein ubiquitinylation" EXACT [] synonym: "protein ubiquitylation" EXACT [] xref: MIPS_funcat:14.07.05 is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016569 name: covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah, GOC:vw] synonym: "chromatin modification" EXACT [] is_a: GO:0006325 ! chromatin organization is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0016570 name: histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] subset: goslim_yeast xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0016571 name: histone methylation namespace: biological_process def: "The modification of histones by addition of methyl groups." [GOC:ai] xref: Wikipedia:Histone_methylation is_a: GO:0006479 ! protein methylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016572 name: histone phosphorylation namespace: biological_process def: "The modification of histones by addition of phosphate groups." [GOC:ai] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016573 name: histone acetylation namespace: biological_process def: "The modification of a histone by the addition of an acetyl group." [GOC:ai] is_a: GO:0016570 ! histone modification is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0016574 name: histone ubiquitination namespace: biological_process def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] synonym: "histone ubiquitinylation" EXACT [] synonym: "histone ubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0016570 ! histone modification [Term] id: GO:0016575 name: histone deacetylation namespace: biological_process def: "The modification of histones by removal of acetyl groups." [GOC:ai] is_a: GO:0006476 ! protein deacetylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016576 name: histone dephosphorylation namespace: biological_process def: "The modification of histones by removal of phosphate groups." [GOC:ai] is_a: GO:0006470 ! protein dephosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016577 name: histone demethylation namespace: biological_process def: "The modification of histones by removal of methyl groups." [GOC:ai] is_a: GO:0006482 ! protein demethylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016578 name: histone deubiquitination namespace: biological_process def: "The modification of histones by removal of ubiquitin groups." [GOC:ai] synonym: "histone deubiquitinylation" EXACT [] synonym: "histone deubiquitylation" EXACT [] is_a: GO:0016570 ! histone modification is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0016579 name: protein deubiquitination namespace: biological_process alt_id: GO:0006514 def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai] synonym: "deubiquitination" EXACT [] synonym: "protein deubiquitinylation" EXACT [] synonym: "protein deubiquitylation" EXACT [] xref: MIPS_funcat:14.07.05 is_a: GO:0070646 ! protein modification by small protein removal relationship: has_part GO:0004843 ! thiol-dependent ubiquitin-specific protease activity [Term] id: GO:0016580 name: Sin3 complex namespace: cellular_component def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0016581 name: NuRD complex namespace: cellular_component def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] synonym: "Mi-2 complex" EXACT [] synonym: "NRD complex" EXACT [] synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0090545 ! CHD-type complex is_a: GO:0090568 ! nuclear transcriptional repressor complex [Term] id: GO:0016582 name: obsolete non-covalent chromatin modification namespace: biological_process def: "OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl, GOC:vw] comment: This term was made obsolete because it was added in error; its usefulness is unclear. is_obsolete: true [Term] id: GO:0016583 name: obsolete nucleosome modeling namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it has been replaced by more specific terms. synonym: "nucleosome modeling" EXACT [] is_obsolete: true consider: GO:0006334 [Term] id: GO:0016584 name: nucleosome positioning namespace: biological_process def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] synonym: "nucleosome spacing" EXACT [] is_a: GO:0031497 ! chromatin assembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0016585 name: obsolete chromatin remodeling complex namespace: cellular_component alt_id: GO:0005679 def: "OBSOLETE. Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. synonym: "chromatin remodeling complex" EXACT [] synonym: "chromatin remodelling complex" EXACT [] synonym: "nucleosome remodeling complex" EXACT [] is_obsolete: true consider: GO:0006338 [Term] id: GO:0016586 name: RSC-type complex namespace: cellular_component alt_id: GO:0070604 def: "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining" [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231] comment: Term name, synonym and definition discussed in https://github.com/geneontology/go-ontology/issues/14106 synonym: "PBAF complex" EXACT [] synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565] synonym: "SWI/SNF complex B" EXACT [CORUM:565] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: midori creation_date: 2009-04-29T01:07:26Z [Term] id: GO:0016587 name: Isw1 complex namespace: cellular_component def: "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016589 name: NURF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "nucleosome remodeling factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016590 name: ACF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016591 name: RNA polymerase II, holoenzyme namespace: cellular_component def: "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] subset: goslim_pir synonym: "DNA-directed RNA polymerase II, holoenzyme" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0016592 name: mediator complex namespace: cellular_component alt_id: GO:0000119 def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] synonym: "CDK8-containing TRAP/mediator complex" RELATED [] synonym: "L mediator complex" EXACT [] synonym: "Srb-mediator complex" EXACT [GOC:mah] synonym: "TRAP complex" NARROW [] xref: Wikipedia:Mediator_(coactivator) is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0070847 ! core mediator complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0016593 name: Cdc73/Paf1 complex namespace: cellular_component def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] synonym: "Paf1 complex" EXACT [GOC:cjk] synonym: "Paf1p complex" EXACT [GOC:cjk] is_a: GO:0008023 ! transcription elongation factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0016594 name: glycine binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0016597 ! amino acid binding is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] id: GO:0016595 name: glutamate binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0016596 name: thienylcyclohexylpiperidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl] synonym: "TCP binding" BROAD [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir xref: MIPS_funcat:16.11 is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0016598 name: protein arginylation namespace: biological_process alt_id: GO:0019130 def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865] synonym: "protein amino acid arginylation" EXACT [] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0016600 name: flotillin complex namespace: cellular_component def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] comment: See also the cellular component term 'caveola ; GO:0005901'. is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005901 ! caveola [Term] id: GO:0016601 name: Rac protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rac mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0016602 name: CCAAT-binding factor complex namespace: cellular_component def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] synonym: "CBF complex" RELATED [GOC:bhm] synonym: "NF-Y transcription factor complex" RELATED [GOC:bhm] synonym: "nuclear transcription factor Y complex" RELATED [GOC:bhm] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0016603 name: glutaminyl-peptide cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] xref: EC:2.3.2.5 xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016604 name: nuclear body namespace: cellular_component def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] xref: NIF_Subcellular:sao505137457 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0016605 name: PML body namespace: cellular_component def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] synonym: "ND10" EXACT [] synonym: "nuclear dot" RELATED [] synonym: "PML NB" EXACT [] synonym: "PML nuclear body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016606 name: LYSP100-associated nuclear domain namespace: cellular_component def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863] synonym: "LANDs" EXACT [PMID:8695863] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016607 name: nuclear speck namespace: cellular_component def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] synonym: "nuclear speckle" EXACT [] synonym: "nuclear speckles" EXACT [] synonym: "speckle domain" NARROW [] synonym: "speckle focus" RELATED [] synonym: "splicing speckle" EXACT [] xref: MIPS_funcat:70.10.09 is_a: GO:0016604 ! nuclear body [Term] id: GO:0016608 name: growth hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732] synonym: "GHRF activity" EXACT [ISBN:0198506732] synonym: "GHRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016610 name: nitrogenase complex namespace: cellular_component def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] subset: goslim_pir is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0016611 name: iron-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016612 name: molybdenum-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] synonym: "molybdenum-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016613 name: vanadium-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] synonym: "vanadium-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016614 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1 xref: Reactome:R-HSA-1500781 "Fgd1 reactivates F420" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016615 name: malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016616 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] xref: EC:1.1.1 xref: Reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016617 name: 4-oxoproline reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104] synonym: "hydroxy-L-proline oxidase activity" EXACT [] synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104] xref: EC:1.1.1.104 xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN xref: RHEA:13601 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016618 name: hydroxypyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81] synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] xref: EC:1.1.1.81 xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN xref: MetaCyc:RXN0-300 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016620 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.2.1 xref: Reactome:R-HSA-1222583 "MscR reduces nitrosomycothiol to ammonia" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016621 name: cinnamoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44] synonym: "cinnamoyl CoA reductase activity" EXACT [] synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44] synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] xref: EC:1.2.1.44 xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN xref: RHEA:10620 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0016622 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.2.2 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016623 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.2.3 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016624 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] xref: EC:1.2.4 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016625 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.2.7 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016626 name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016903 [Term] id: GO:0016627 name: oxidoreductase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 xref: Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016628 name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.3.1 xref: Reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL" xref: Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016629 name: 12-oxophytodienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21888] synonym: "12-oxo-phytodienoate reductase activity" EXACT [] synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42] synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42] xref: EC:1.3.1.42 xref: KEGG_REACTION:R03401 xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN xref: RHEA:21888 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016630 name: protochlorophyllide reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33] xref: EC:1.3.1.33 xref: MetaCyc:RXN1F-10 xref: RHEA:11132 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016631 name: enoyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "enoyl-ACP reductase activity" EXACT [] synonym: "enoyl-acyl carrier protein reductase" EXACT [] xref: EC:1.3.1.9 xref: MetaCyc:1.3.1.10-RXN xref: MetaCyc:1.3.1.39-RXN xref: MetaCyc:RXN1G-2527 xref: MetaCyc:RXN1G-2544 xref: MetaCyc:RXN1G-3232 xref: MetaCyc:RXN1G-3256 xref: MetaCyc:RXN1G-3613 xref: MetaCyc:RXN1G-3641 xref: MetaCyc:RXN1G-3667 xref: MetaCyc:RXN1G-3993 xref: MetaCyc:RXN1G-4140 xref: MetaCyc:RXN1G-45 xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016632 name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.3.2 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016633 name: galactonolactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] synonym: "GLDase activity" EXACT [EC:1.3.2.3] synonym: "GLDHase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] xref: EC:1.3.2.3 xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: GO:0016634 name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.3.3 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016635 name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] xref: EC:1.3.5 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016636 name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.3.7 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016637 name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016627 [Term] id: GO:0016638 name: oxidoreductase activity, acting on the CH-NH2 group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] xref: EC:1.4 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016639 name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] xref: EC:1.4.1 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016640 name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.4.2 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016641 name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.4.3 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016642 name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] xref: EC:1.4.4 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016643 name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.4.7 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016644 name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016638 [Term] id: GO:0016645 name: oxidoreductase activity, acting on the CH-NH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] xref: EC:1.5 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016646 name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.5.1 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016647 name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.5.3 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016648 name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.5.4 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016649 name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] xref: EC:1.5.5 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016650 name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016645 [Term] id: GO:0016651 name: oxidoreductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. synonym: "NAD(P)H dehydrogenase" NARROW [] synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] xref: EC:1.6 xref: Reactome:R-HSA-109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:R-HSA-8956458 "RNLS:FAD oxidises dh-beta-NAD to NAD+" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016652 name: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] synonym: "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor" RELATED [] xref: EC:1.6.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016653 name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED [] xref: EC:1.6.2 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016655 name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED [] xref: EC:1.6.5 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016656 name: monodehydroascorbate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] synonym: "AFR" RELATED [EC:1.6.5.4] synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4] synonym: "MDHA" RELATED [EC:1.6.5.4] synonym: "monodehydroascorbate reductase activity" EXACT [] synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "SDA reductase activity" EXACT [EC:1.6.5.4] synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4] xref: EC:1.6.5.4 xref: MetaCyc:1.6.5.4-RXN xref: RHEA:14581 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0016657 name: oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" RELATED [] xref: EC:1.6.6 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016658 name: obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it. synonym: "oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor" EXACT [] is_obsolete: true consider: GO:0008752 consider: GO:0042602 [Term] id: GO:0016659 name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" EXACT [] is_obsolete: true consider: GO:0016651 [Term] id: GO:0016661 name: oxidoreductase activity, acting on other nitrogenous compounds as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] xref: EC:1.7 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016662 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.7.2 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016663 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.7.3 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016664 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.7.7 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016665 name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016661 [Term] id: GO:0016667 name: oxidoreductase activity, acting on a sulfur group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] xref: EC:1.8 xref: Reactome:R-HSA-2213240 "Reduction of disulphide bonds in MHC II antigens" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016668 name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor namespace: molecular_function alt_id: GO:0016654 def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] xref: EC:1.8.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016669 name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] xref: EC:1.8.2 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016670 name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] xref: EC:1.8.3 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016671 name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] xref: EC:1.8.4 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016672 name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] xref: EC:1.8.5 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016673 name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.8.7 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016674 name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016667 [Term] id: GO:0016675 name: oxidoreductase activity, acting on a heme group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] xref: EC:1.9 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016676 name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] xref: EC:1.9.3 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016677 name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] xref: EC:1.9.6 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016678 name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016675 [Term] id: GO:0016679 name: oxidoreductase activity, acting on diphenols and related substances as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] xref: EC:1.10 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016680 name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.10.1 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016681 name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.10.2 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016682 name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "laccase activity" RELATED [GOC:jh] xref: EC:1.10.3 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016683 name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016679 [Term] id: GO:0016684 name: oxidoreductase activity, acting on peroxide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.11 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016688 name: L-ascorbate peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11] synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11] synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] xref: EC:1.11.1.11 xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016689 name: manganese peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13] synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] xref: EC:1.11.1.13 xref: MetaCyc:MANGANESE-PEROXIDASE-RXN xref: RHEA:22776 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016690 name: diarylpropane peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14] synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14] synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14] synonym: "ligninase activity" EXACT [EC:1.11.1.14] synonym: "ligninase I activity" NARROW [EC:1.11.1.14] synonym: "LiP activity" NARROW [EC:1.11.1.14] xref: EC:1.11.1.14 xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN xref: RHEA:30271 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016691 name: chloride peroxidase activity namespace: molecular_function alt_id: GO:0016955 alt_id: GO:0016956 alt_id: GO:0016957 alt_id: GO:0016958 def: "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10] synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10] synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10] synonym: "cofactor-free chloroperoxidase activity" NARROW [] synonym: "flavin-haem chloroperoxidase activity" NARROW [] synonym: "flavin-heme chloroperoxidase activity" NARROW [] synonym: "haem chloroperoxidase activity" NARROW [] synonym: "heme chloroperoxidase activity" NARROW [] synonym: "vanadium chloroperoxidase activity" NARROW [] xref: EC:1.11.1.10 xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016692 name: NADH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+)." [EC:1.11.1.1, RHEA:18509] synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1] synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1] synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1] xref: EC:1.11.1.1 xref: KEGG_REACTION:R00090 xref: MetaCyc:NADH-PEROXIDASE-RXN xref: RHEA:18509 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016694 name: obsolete bacterial catalase-peroxidase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a bifunctional gene product. synonym: "bacterial catalase-peroxidase activity" EXACT [] is_obsolete: true consider: GO:0004096 consider: GO:0004601 [Term] id: GO:0016695 name: oxidoreductase activity, acting on hydrogen as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] xref: EC:1.12 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016696 name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.12.1 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016697 name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor namespace: molecular_function alt_id: GO:0016698 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.12.2 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016699 name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor namespace: molecular_function alt_id: GO:0016736 alt_id: GO:0019110 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.12.7 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016700 name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" EXACT [] is_obsolete: true consider: GO:0016695 [Term] id: GO:0016701 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] synonym: "oxygenase" BROAD [] xref: EC:1.13 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016702 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] xref: EC:1.13.11 xref: Reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4" xref: Reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4" xref: Reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4" xref: Reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION" xref: Reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE" xref: Reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA" xref: Reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3" xref: Reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA" is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016703 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] xref: EC:1.13.12 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0016704 name: obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" EXACT [] is_obsolete: true consider: GO:0016701 [Term] id: GO:0016705 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] xref: EC:1.14 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016706 name: 2-oxoglutarate-dependent dioxygenase activity namespace: molecular_function alt_id: GO:0010302 def: "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] synonym: "2-oxoglutarate dioxygenase activity" EXACT [] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" EXACT [] xref: EC:1.14.11 xref: Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)" xref: Reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016707 name: gibberellin 3-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad] synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15] xref: EC:1.14.11.15 xref: MetaCyc:RXN1F-170 xref: RHEA:10104 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0016708 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor" RELATED [] xref: EC:1.14.12 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016709 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen" RELATED [] xref: EC:1.14.13 xref: Reactome:R-HSA-2162187 "DHB is hydroxylated to DHDB by COQ6" xref: Reactome:R-HSA-2162194 "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016710 name: trans-cinnamate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.14.91] synonym: "CA4H activity" NARROW [EC:1.14.14.91] synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.14.91] synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.14.91] synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.14.91] synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.14.91] synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.14.91] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.14.91] synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.14.91] xref: EC:1.14.14.91 xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN xref: RHEA:10608 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016711 name: flavonoid 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.14.82] synonym: "flavonoid 3'-hydroxylase activity" EXACT [b] synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.14.82] synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.14.82] synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.82] synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.14.82] xref: EC:1.14.14.82 xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN xref: RHEA:16337 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016712 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen namespace: molecular_function alt_id: GO:0008402 alt_id: GO:0050381 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1] synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] synonym: "cytochrome P450 CYP19" NARROW [] synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "microsomal P-450" RELATED [EC:1.14.14.1] synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1] synonym: "unspecific monooxygenase activity" RELATED [] synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] xref: EC:1.14.14 xref: Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine" xref: UM-BBD_enzymeID:e0551 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016713 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] xref: EC:1.14.15 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016714 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.16 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016715 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.17 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016716 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.18 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016717 name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] xref: EC:1.14.19 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016718 name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" EXACT [] is_obsolete: true consider: GO:0016705 [Term] id: GO:0016719 name: carotene 7,8-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30] synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30] xref: EC:1.14.99.30 xref: MetaCyc:1.14.99.30-RXN xref: RHEA:15701 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016720 name: delta12-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23456] synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] synonym: "D12-fatty acid dehydrogenase activity" EXACT [] synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33] synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33] xref: EC:1.14.99.33 xref: KEGG_REACTION:R05740 xref: MetaCyc:1.14.99.33-RXN xref: RHEA:23456 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016721 name: oxidoreductase activity, acting on superoxide radicals as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.15 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016722 name: oxidoreductase activity, oxidizing metal ions namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] xref: EC:1.16 xref: Reactome:R-HSA-917805 "CYBRD1:Heme reduces Fe3+ to Fe2+" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016723 name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] xref: EC:1.16.1 xref: Reactome:R-HSA-917811 "STEAP3-like proteins reduce Fe3+ to Fe2+" is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016724 name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] xref: EC:1.16.3 is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016725 name: oxidoreductase activity, acting on CH or CH2 groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] xref: EC:1.17 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016726 name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] xref: EC:1.17.1 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016727 name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.17.3 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016728 name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] xref: EC:1.17.4 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016729 name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on CH2 groups, other acceptors" EXACT [] is_obsolete: true consider: GO:0016725 [Term] id: GO:0016730 name: oxidoreductase activity, acting on iron-sulfur proteins as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] xref: EC:1.18 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016731 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.18.1 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016732 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] xref: EC:1.18.6 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016733 name: obsolete iron-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "iron-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016611 [Term] id: GO:0016734 name: obsolete molybdenum-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "molybdenum-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016612 [Term] id: GO:0016735 name: obsolete vanadium-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "vanadium-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016613 [Term] id: GO:0016737 name: oxidoreductase activity, acting on reduced flavodoxin as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.19 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016738 name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] xref: EC:1.19.6 is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor [Term] id: GO:0016739 name: obsolete oxidoreductase activity, acting on other substrates namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on other substrates" EXACT [] is_obsolete: true consider: GO:0016491 [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2 xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-6787403 "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016741 name: transferase activity, transferring one-carbon groups namespace: molecular_function def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] xref: EC:2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016742 name: hydroxymethyl-, formyl- and related transferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah] xref: EC:2.1.2 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016743 name: carboxyl- or carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] xref: EC:2.1.3 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016744 name: transferase activity, transferring aldehyde or ketonic groups namespace: molecular_function alt_id: GO:0016745 def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "transketolase or transaldolase activity" EXACT [] xref: EC:2.2 xref: EC:2.2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016746 name: transferase activity, transferring acyl groups namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "acyltransferase activity" EXACT [] xref: EC:2.3 xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: Reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016747 name: transferase activity, transferring acyl groups other than amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1] xref: EC:2.3.1 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0016748 name: succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016749 name: N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016750 name: O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016751 name: S-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016752 name: sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016753 name: O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016752 ! sinapoyltransferase activity [Term] id: GO:0016754 name: sinapoylglucose-malate O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12625] synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] xref: EC:2.3.1.92 xref: KEGG_REACTION:R03323 xref: MetaCyc:2.3.1.92-RXN xref: RHEA:12625 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0016755 name: transferase activity, transferring amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "aminoacyltransferase activity" EXACT [] xref: EC:2.3.2 is_a: GO:0016746 ! transferase activity, transferring acyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016756 name: glutathione gamma-glutamylcysteinyltransferase activity namespace: molecular_function alt_id: GO:0042143 def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: MetaCyc:2.3.2.15-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016757 name: transferase activity, transferring glycosyl groups namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 xref: Reactome:R-HSA-5173005 "B3GALTL transfers glucose to O-fucosyl-proteins" xref: Reactome:R-HSA-6785565 "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016758 name: transferase activity, transferring hexosyl groups namespace: molecular_function def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "hexosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016759 name: cellulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29] is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0016760 name: cellulose synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "GS-I" RELATED [EC:2.4.1.12] synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] xref: EC:2.4.1.12 xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016761 name: cellulose synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.29 xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity [Term] id: GO:0016762 name: xyloglucan:xyloglucosyl transferase activity namespace: molecular_function alt_id: GO:0080039 def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366] synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207] synonym: "endoxyloglucan transferase activity" EXACT [] synonym: "xyloglucan endotransglucosylase activity" EXACT [EC:2.4.1.207] synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207] xref: EC:2.4.1.207 xref: MetaCyc:2.4.1.207-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0016763 name: transferase activity, transferring pentosyl groups namespace: molecular_function def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "pentosyltransferase activity" EXACT [] xref: EC:2.4.2 xref: Reactome:R-HSA-112265 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]" xref: Reactome:R-HSA-112266 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016764 name: obsolete transferase activity, transferring other glycosyl groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "transferase activity, transferring other glycosyl groups" EXACT [] is_obsolete: true consider: GO:0016757 [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: EC:2.5.1 xref: Reactome:R-HSA-4419978 "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP" xref: Reactome:R-HSA-4755545 "Defective DHDDS does not elongate E,E-FPP" xref: Reactome:R-HSA-6782893 "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016767 name: geranylgeranyl-diphosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32] synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32] synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32] synonym: "PSase activity" EXACT [EC:2.5.1.32] xref: EC:2.5.1.32 xref: MetaCyc:2.5.1.32-RXN xref: RHEA:22296 is_a: GO:0004337 ! geranyltranstransferase activity [Term] id: GO:0016768 name: spermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22] xref: EC:2.5.1.22 xref: MetaCyc:SPERMINE-SYNTHASE-RXN xref: Reactome:R-HSA-351210 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine" xref: RHEA:19973 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0016769 name: transferase activity, transferring nitrogenous groups namespace: molecular_function def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term. synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] xref: EC:2.6 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016770 name: oximinotransaminase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai] xref: EC:2.6.3 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0016771 name: obsolete transferase activity, transferring other nitrogenous groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "transferase activity, transferring other nitrogenous groups" EXACT [] is_obsolete: true consider: GO:0016769 [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] subset: goslim_drosophila xref: EC:2.7.1 xref: Reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016774 name: phosphotransferase activity, carboxyl group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] xref: EC:2.7.2 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016775 name: phosphotransferase activity, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] xref: EC:2.7.3 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016776 name: phosphotransferase activity, phosphate group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] xref: EC:2.7.4 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016778 name: diphosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.6 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7 xref: Reactome:R-HSA-6782434 "THG1L transfers GMP to 5' end of tRNA(His)" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016780 name: phosphotransferase activity, for other substituted phosphate groups namespace: molecular_function def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.8 xref: Reactome:R-HSA-162742 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" xref: Reactome:R-HSA-163069 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016781 name: phosphotransferase activity, paired acceptors namespace: molecular_function def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.9 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016782 name: transferase activity, transferring sulfur-containing groups namespace: molecular_function def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "transferase activity, transferring sulphur-containing groups" EXACT [] xref: EC:2.8 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016783 name: sulfurtransferase activity namespace: molecular_function def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] synonym: "sulphurtransferase activity" EXACT [] synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah] xref: EC:2.8.1 xref: Reactome:R-HSA-1614618 "Persulfide sulfur is transferred onto sulfite" xref: Reactome:R-HSA-6782264 "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs" xref: Reactome:R-HSA-947538 "Transfer of sulfur from MOCS3-S-S onto MOCS2A" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0016784 name: 3-mercaptopyruvate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] xref: EC:2.8.1.2 xref: MetaCyc:MERCAPYSTRANS-RXN xref: Reactome:R-HSA-9012721 "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR" xref: Reactome:R-HSA-9013471 "MPST transfers sulfur from 3MPYR to HCN to form HSCN" xref: Reactome:R-HSA-9013533 "MPST transfers sulfur from sulfanegen to HCN to form HSCN" xref: Reactome:R-HSA-9034756 "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST" xref: RHEA:21740 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0016785 name: transferase activity, transferring selenium-containing groups namespace: molecular_function alt_id: GO:0016786 def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "selenotransferase activity" EXACT [] xref: EC:2.9 xref: EC:2.9.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3 xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: goslim_chembl synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid" xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016790 name: thiolester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] synonym: "thiolesterase activity" EXACT [] xref: EC:3.1.2 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" xref: RHEA:21664 is_a: GO:0042578 ! phosphoric ester hydrolase activity relationship: part_of GO:0016311 ! dephosphorylation [Term] id: GO:0016793 name: triphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] xref: EC:3.1.5 xref: Reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate" is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016794 name: diphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] xref: EC:3.1.7 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016795 name: phosphoric triester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8, GOC:curators] xref: EC:3.1.8 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016796 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.15 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016797 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. xref: EC:3.1.16 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016799 name: hydrolase activity, hydrolyzing N-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] xref: EC:3.2.2 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0016801 name: hydrolase activity, acting on ether bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] xref: EC:3.3 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016802 name: trialkylsulfonium hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] synonym: "thioether hydrolase activity" EXACT [] synonym: "trialkylsulphonium hydrolase activity" EXACT [] xref: EC:3.3.1 is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016803 name: ether hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] xref: EC:3.3.2 xref: Reactome:R-HSA-8874435 "THEM86B hydrolyses PMCHO, PMETAM" is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016804 name: obsolete prolyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] synonym: "proline iminopeptidase activity" EXACT [] synonym: "prolyl aminopeptidase activity" EXACT [] xref: EC:3.4.11.5 xref: MetaCyc:3.4.11.5-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0016805 name: dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] xref: EC:3.4.13 xref: Reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2" xref: Reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG" xref: Reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG" xref: Reactome:R-HSA-9026771 "DPEP hydroyses MCTR2 to MCTR3" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0016806 name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] comment: This term was made obsolete because it represents two activities. synonym: "dipeptidyl-peptidase and tripeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14 is_obsolete: true [Term] id: GO:0016807 name: cysteine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] xref: EC:3.4.18 xref: MetaCyc:3.4.18.1-RXN is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070004 ! cysteine-type exopeptidase activity [Term] id: GO:0016808 name: obsolete proprotein convertase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "proprotein convertase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016811 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] xref: EC:3.5.1 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016812 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] xref: EC:3.5.2 xref: Reactome:R-HSA-70906 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016813 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] xref: EC:3.5.3 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016814 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] xref: EC:3.5.4 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016815 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [GOC:curators] xref: EC:3.5.5 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016816 name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" EXACT [] is_obsolete: true consider: GO:0016810 [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] xref: EC:3.6.1 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016819 name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] xref: EC:3.6.2 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016821 name: obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates process information. synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" EXACT [] is_obsolete: true replaced_by: GO:0016817 [Term] id: GO:0016822 name: hydrolase activity, acting on acid carbon-carbon bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] xref: EC:3.7 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016823 name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] xref: EC:3.7.1 is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: GO:0016824 name: hydrolase activity, acting on acid halide bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] xref: EC:3.8 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016825 name: hydrolase activity, acting on acid phosphorus-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] xref: EC:3.9 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016826 name: hydrolase activity, acting on acid sulfur-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] xref: EC:3.10 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016827 name: hydrolase activity, acting on acid carbon-phosphorus bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] xref: EC:3.11 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016828 name: hydrolase activity, acting on acid sulfur-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] xref: EC:3.12 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other lyase activity" NARROW [] xref: EC:4 xref: Reactome:R-HSA-5696408 "PHYKPL tetramer hydrolyses 5PHL" xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016830 name: carbon-carbon lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term. synonym: "other carbon-carbon lyase activity" NARROW [] xref: EC:4.1 xref: Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA" is_a: GO:0016829 ! lyase activity [Term] id: GO:0016831 name: carboxy-lyase activity namespace: molecular_function def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] synonym: "decarboxylase activity" EXACT [] xref: EC:4.1.1 xref: Reactome:R-HSA-6787757 "GADL1 decarboxylates acidic AAs" xref: Reactome:R-HSA-6814165 "GADL1 decarboxylates CSA to HTAU" xref: Reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2" is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016832 name: aldehyde-lyase activity namespace: molecular_function alt_id: GO:0016228 def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] synonym: "aldolase activity" BROAD [] xref: EC:4.1.2 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016833 name: oxo-acid-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl] synonym: "oxo-acid lyase activity" EXACT [] synonym: "oxoacid lyase activity" EXACT [] xref: EC:4.1.3 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016834 name: obsolete other carbon-carbon lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-carbon lyase activity" EXACT [] is_obsolete: true consider: GO:0016830 [Term] id: GO:0016835 name: carbon-oxygen lyase activity namespace: molecular_function def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. synonym: "other carbon-oxygen lyase activity" NARROW [] xref: EC:4.2 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016836 name: hydro-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] xref: EC:4.2.1 xref: Reactome:R-HSA-9014627 "SDS dimers:PXLP dehydrate L-Thr to 2AA" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016837 name: carbon-oxygen lyase activity, acting on polysaccharides namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] xref: EC:4.2.2 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016838 name: carbon-oxygen lyase activity, acting on phosphates namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-] xref: EC:4.2.3 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016839 name: obsolete other carbon-oxygen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-oxygen lyase activity" EXACT [] is_obsolete: true consider: GO:0016835 [Term] id: GO:0016840 name: carbon-nitrogen lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term. synonym: "other carbon-nitrogen lyase activity" NARROW [] xref: EC:4.3 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016841 name: ammonia-lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.1 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016842 name: amidine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.2 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016843 name: amine-lyase activity namespace: molecular_function def: "Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.3 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016844 name: strictosidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15013] synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2] synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2] synonym: "STR activity" EXACT [EC:4.3.3.2] synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2] xref: EC:4.3.3.2 xref: KEGG_REACTION:R03738 xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN xref: RHEA:15013 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0016845 name: obsolete other carbon-nitrogen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-nitrogen lyase activity" EXACT [] is_obsolete: true consider: GO:0016840 [Term] id: GO:0016846 name: carbon-sulfur lyase activity namespace: molecular_function def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-] synonym: "carbon-sulphur lyase activity" EXACT [] xref: EC:4.4 xref: Reactome:R-HSA-1614567 "Excess homocysteine yields homolanthionine and H2S" is_a: GO:0016829 ! lyase activity [Term] id: GO:0016847 name: 1-aminocyclopropane-1-carboxylate synthase activity namespace: molecular_function alt_id: GO:0034100 def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21744] comment: Note that this function was formerly EC:4.1.99.4. synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "ACC synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "L-VG deaminase activity" RELATED [PMID:11470512] synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14] xref: EC:4.4.1.14 xref: KEGG_REACTION:R00179 xref: MetaCyc:4.4.1.14-RXN xref: RHEA:21744 is_a: GO:0016846 ! carbon-sulfur lyase activity relationship: part_of GO:0042218 ! 1-aminocyclopropane-1-carboxylate biosynthetic process [Term] id: GO:0016848 name: carbon-halide lyase activity namespace: molecular_function def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] xref: EC:4.5 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016849 name: phosphorus-oxygen lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] xref: EC:4.6 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016850 name: obsolete other lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other lyase activity" EXACT [] is_obsolete: true consider: GO:0016829 [Term] id: GO:0016851 name: magnesium chelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13961] comment: Note that this was EC:4.99.1.1. synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1] xref: EC:6.6.1.1 xref: KEGG_REACTION:R03877 xref: MetaCyc:RXN1F-20 xref: RHEA:13961 is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: GO:0016852 name: sirohydrochlorin cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3] synonym: "anaerobic cobalt chelatase activity" EXACT [] synonym: "CbiK" NARROW [] synonym: "CbiX" RELATED [EC:4.99.1.3] synonym: "CbiXS" RELATED [EC:4.99.1.3] synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3] synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3] xref: EC:4.99.1.3 xref: MetaCyc:4.99.1.3-RXN xref: RHEA:15893 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5 xref: Reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016854 name: racemase and epimerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732] comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] xref: EC:5.1 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016855 name: racemase and epimerase activity, acting on amino acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] xref: EC:5.1.1 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016856 name: racemase and epimerase activity, acting on hydroxy acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] xref: EC:5.1.2 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016857 name: racemase and epimerase activity, acting on carbohydrates and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] xref: EC:5.1.3 xref: Reactome:R-HSA-6787677 "FUOM isomerises alpha-Fuc to beta-Fuc" is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016858 name: obsolete racemase and epimerase activity, acting on other compounds namespace: molecular_function def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "racemase and epimerase activity, acting on other compounds" EXACT [] is_obsolete: true consider: GO:0016854 [Term] id: GO:0016859 name: cis-trans isomerase activity namespace: molecular_function def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732] xref: EC:5.2 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016860 name: intramolecular oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-] comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term. synonym: "intramolecular isomerase activity" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] xref: EC:5.3 xref: Reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016861 name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl] synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] xref: EC:5.3.1 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016862 name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl] synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] xref: EC:5.3.2 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016863 name: intramolecular oxidoreductase activity, transposing C=C bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah] synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] xref: EC:5.3.3 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016864 name: intramolecular oxidoreductase activity, transposing S-S bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah] synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] xref: EC:5.3.4 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016865 name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" EXACT [] is_obsolete: true consider: GO:0016860 [Term] id: GO:0016866 name: intramolecular transferase activity namespace: molecular_function def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. synonym: "intramolecular transferase activity, transferring other groups" NARROW [] synonym: "mutase activity" EXACT [] xref: EC:5.4 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016867 name: intramolecular transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] xref: EC:5.4.1 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016868 name: intramolecular transferase activity, phosphotransferases namespace: molecular_function alt_id: GO:0016777 def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] synonym: "phosphomutase activity" EXACT [] synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT [] xref: EC:5.4.2 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016869 name: intramolecular transferase activity, transferring amino groups namespace: molecular_function def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] xref: EC:5.4.3 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016870 name: obsolete intramolecular transferase activity, transferring other groups namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "intramolecular transferase activity, transferring other groups" EXACT [] is_obsolete: true consider: GO:0016866 [Term] id: GO:0016871 name: cycloartenol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21308] synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] xref: EC:5.4.99.8 xref: KEGG_REACTION:R03200 xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN xref: RHEA:21308 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0016872 name: intramolecular lyase activity namespace: molecular_function def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] xref: EC:5.5.1 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016873 name: obsolete other isomerase activity namespace: molecular_function def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other isomerase activity" EXACT [] is_obsolete: true consider: GO:0016853 [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016875 name: ligase activity, forming carbon-oxygen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1, GOC:mah] xref: EC:6.1 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah] synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016878 name: acid-thiol ligase activity namespace: molecular_function def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1, GOC:mah] xref: EC:6.2.1 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016879 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah] comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016880 name: acid-ammonia (or amide) ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] synonym: "amide synthase activity" EXACT [] xref: EC:6.3.1 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016881 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016882 name: cyclo-ligase activity namespace: molecular_function def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah] xref: EC:6.3.3 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016883 name: obsolete other carbon-nitrogen ligase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-nitrogen ligase activity" EXACT [] is_obsolete: true consider: GO:0016879 [Term] id: GO:0016884 name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor namespace: molecular_function alt_id: GO:0016003 def: "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532] comment: Changed definition as requested in https://github.com/geneontology/go-ontology/issues/16422 xref: EC:6.3.5 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016885 name: ligase activity, forming carbon-carbon bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4, GOC:jl, GOC:mah] xref: EC:6.4 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016886 name: ligase activity, forming phosphoric ester bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5, GOC:mah] xref: EC:6.5 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016887 name: ATPase activity namespace: molecular_function alt_id: GO:0004002 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" NARROW [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-72139 "Formation of the active Spliceosomal C (B*) complex" xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" xref: Reactome:R-HSA-917693 "ESCRT Disassembly" xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" xref: RHEA:13065 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0016888 name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.21 xref: Reactome:R-HSA-912368 "SPO11 hydrolyzes DNA forming double-strand breaks" is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016889 name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.22 is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016890 name: site-specific endodeoxyribonuclease activity, specific for altered base namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] xref: EC:3.1.25 is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0016891 name: endoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] xref: EC:3.1.26 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016892 name: endoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.27 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016893 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "5'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] xref: EC:3.1.30 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016894 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "3'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] xref: EC:3.1.31 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016895 name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function alt_id: GO:0008858 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] synonym: "exonuclease VIII activity" NARROW [] xref: EC:3.1.11 is_a: GO:0004529 ! exodeoxyribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016896 name: exoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.13 xref: Reactome:R-HSA-429860 "DCP1-DCP2 complex decaps mRNA" is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016897 name: exoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] xref: EC:3.1.14 is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016898 name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.1.2 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016899 name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.1.3 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016900 name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.1.4 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016901 name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] xref: EC:1.1.5 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016902 name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016614 [Term] id: GO:0016903 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] xref: EC:1.2 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016905 name: myosin heavy chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7] synonym: "MHCK" RELATED [EC:2.7.11.7] synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin I heavy chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "STK6" RELATED [EC:2.7.11.7] xref: EC:2.7.11.7 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0016906 name: sterol 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173, RHEA:22724] synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol glucosyltransferase activity" EXACT [] synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173] synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] xref: EC:2.4.1.173 xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN xref: RHEA:22724 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016907 name: G protein-coupled acetylcholine receptor activity namespace: molecular_function alt_id: GO:0004981 def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein coupled acetylcholine receptor activity" EXACT [] synonym: "metabotropic acetylcholine receptor activity" EXACT [] synonym: "muscarinic acetylcholine receptor activity" EXACT [] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0015464 ! acetylcholine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity relationship: part_of GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0016909 name: SAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma] synonym: "SAPK" EXACT [] synonym: "stress-activated kinase activity" EXACT [] synonym: "stress-activated protein kinase activity" EXACT [] is_a: GO:0004707 ! MAP kinase activity [Term] id: GO:0016910 name: obsolete SAP kinase 3 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAP kinase 3 activity" EXACT [] synonym: "SAPK3" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016911 name: obsolete SAP kinase 4 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAP kinase 4 activity" EXACT [] synonym: "SAPK4" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016912 name: obsolete SAP kinase 5 activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product. synonym: "SAP kinase 5 activity" EXACT [] synonym: "SAPK5" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016913 name: follicle-stimulating hormone activity namespace: molecular_function def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684] synonym: "follicle stimulating hormone activity" EXACT [] synonym: "follitropin activity" EXACT [ISBN:0198506732] synonym: "FSH activity" EXACT [GOC:mah] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016914 name: follicle-stimulating hormone complex namespace: cellular_component def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] synonym: "follicle stimulating hormone complex" EXACT [] synonym: "FSH complex" EXACT [] is_a: GO:0061696 ! pituitary gonadotropin complex [Term] id: GO:0016915 name: obsolete activin namespace: molecular_function def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "activin" EXACT [] is_obsolete: true consider: GO:0005160 consider: GO:0046881 [Term] id: GO:0016916 name: obsolete inhibin namespace: molecular_function def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "inhibin" EXACT [] is_obsolete: true consider: GO:0005160 consider: GO:0046882 [Term] id: GO:0016917 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0016918 name: retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [ISBN:0198506732] synonym: "blue-sensitive opsin" RELATED [] synonym: "green-sensitive opsin" RELATED [] synonym: "long-wave-sensitive opsin" RELATED [] synonym: "opsin" RELATED [] synonym: "red-sensitive opsin" RELATED [] synonym: "retinaldehyde binding" EXACT [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "UV-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] synonym: "vitamin A binding" BROAD [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0016919 name: obsolete nardilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61] comment: This term was made obsolete because it represents a gene product. synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] synonym: "nardilysin activity" EXACT [] synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] xref: EC:3.4.24.61 xref: MetaCyc:3.4.24.61-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016920 name: pyroglutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] xref: EC:3.4.19 is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0016921 name: obsolete pyroglutamyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] comment: This term was made obsolete because it represents a gene product. synonym: "PAP-II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl-peptidase II activity" EXACT [] synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] xref: EC:3.4.19.6 xref: MetaCyc:3.4.19.6-RXN is_obsolete: true consider: GO:0008237 consider: GO:0016920 [Term] id: GO:0016922 name: nuclear receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] synonym: "ligand-dependent nuclear receptor binding" EXACT [] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0016923 name: obsolete ligand-dependent thyroid hormone receptor interactor activity namespace: molecular_function def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "ligand-dependent thyroid hormone receptor interactor activity" EXACT [] synonym: "TRIP4" RELATED [] is_obsolete: true consider: GO:0046966 [Term] id: GO:0016925 name: protein sumoylation namespace: biological_process alt_id: GO:0006485 alt_id: GO:0016927 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] synonym: "protein sumolation" EXACT [] synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] synonym: "SUMO-protein conjugation" EXACT [] synonym: "sumoylation" EXACT [] xref: MIPS_funcat:14.07.07 xref: Wikipedia:SUMO_protein is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016926 name: protein desumoylation namespace: biological_process alt_id: GO:0016928 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] synonym: "desumoylation" EXACT [] synonym: "protein desumolation" EXACT [] xref: MIPS_funcat:14.07.07 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0016929 name: SUMO-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within SUMO, or between the SUMO and a larger protein to which it has been conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] comment: This term should not be used for direct manual annotation because the supporting experiments should always distinguish whether the activity is part of maturation or SUMO removal. subset: gocheck_do_not_manually_annotate synonym: "SUSP" NARROW [] synonym: "ULP" NARROW [] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0016933 name: extracellularly glycine-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular-glycine-gated ion channel activity" EXACT [] synonym: "glycine receptor" BROAD [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0016934 name: extracellularly glycine-gated chloride channel activity namespace: molecular_function alt_id: GO:0004891 def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular-glycine-gated chloride channel activity" EXACT [] synonym: "glycine receptor" BROAD [] synonym: "glycine-inhibited chloride channel activity" RELATED [] xref: Reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol" is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity is_a: GO:0005254 ! chloride channel activity is_a: GO:0016933 ! extracellularly glycine-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0016935 name: glycine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0016936 name: galactoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0016937 name: short-branched-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah] xref: EC:1.3.99 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0016938 name: kinesin I complex namespace: cellular_component def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016939 name: kinesin II complex namespace: cellular_component def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016941 name: natriuretic peptide receptor activity namespace: molecular_function def: "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0001653 ! peptide receptor activity [Term] id: GO:0016942 name: insulin-like growth factor binding protein complex namespace: cellular_component def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] subset: goslim_pir synonym: "IGF binding protein complex" EXACT [] is_a: GO:0036454 ! growth factor complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0016943 name: obsolete RNA polymerase I transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription elongation factor activity" EXACT [] synonym: "RNA polymerase I transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006362 [Term] id: GO:0016944 name: obsolete RNA polymerase II transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription elongation factor activity" EXACT [] synonym: "RNA polymerase II transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006368 [Term] id: GO:0016945 name: obsolete RNA polymerase III transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription elongation factor activity" EXACT [] synonym: "RNA polymerase III transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006385 [Term] id: GO:0016946 name: obsolete cathepsin F activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin F activity" EXACT [] xref: EC:3.4.22.41 xref: MetaCyc:3.4.22.41-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0016962 name: obsolete receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and not a molecular function. synonym: "receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016963 name: obsolete alpha-2 macroglobulin receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "alpha-2 macroglobulin receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016964 name: alpha-2 macroglobulin receptor activity namespace: molecular_function def: "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0016966 name: nitric oxide reductase activity namespace: molecular_function alt_id: GO:0016967 alt_id: GO:0016968 def: "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5] synonym: "CYP55" NARROW [] synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.2.5] synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.2.5] synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5] synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5] synonym: "P450 nitric oxide reductase activity" NARROW [] synonym: "P450nor" NARROW [] xref: EC:1.7.2.5 xref: KEGG_REACTION:R00294 xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0016969 name: obsolete hemerythrin namespace: molecular_function def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemerythrin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016970 name: obsolete hemocyanin namespace: molecular_function def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemocyanin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016971 name: flavin-linked sulfhydryl oxidase activity namespace: molecular_function def: "Catalysis of the formation of disulfide bridges." [PMID:10899311] is_a: GO:0016972 ! thiol oxidase activity [Term] id: GO:0016972 name: thiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2] synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2] synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2] xref: EC:1.8.3.2 xref: MetaCyc:THIOL-OXIDASE-RXN xref: RHEA:17357 xref: UM-BBD_reactionID:r1293 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0016973 name: poly(A)+ mRNA export from nucleus namespace: biological_process def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] synonym: "poly(A) mRNA export from nucleus" EXACT [] synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "poly(A)+ mRNA-nucleus export" EXACT [] synonym: "polyadenylated mRNA export from nucleus" RELATED [] is_a: GO:0006406 ! mRNA export from nucleus [Term] id: GO:0016975 name: obsolete alpha-2 macroglobulin namespace: molecular_function def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-2 macroglobulin" EXACT [] is_obsolete: true replaced_by: GO:0004866 [Term] id: GO:0016977 name: chitosanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132] xref: EC:3.2.1.132 xref: MetaCyc:3.2.1.132-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016979 name: lipoate-protein ligase activity namespace: molecular_function alt_id: GO:0008916 alt_id: GO:0016978 alt_id: GO:0102315 def: "Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP." [EC:6.3.1.20] synonym: "lipoate-protein ligase A activity" NARROW [] synonym: "lipoate-protein ligase activity (lipoylation of glycine cleavage complex)" NARROW [] synonym: "lipoate-protein ligase B activity" NARROW [] xref: MetaCyc:RXN-13039 xref: MetaCyc:RXN-8654 xref: MetaCyc:RXN-8655 xref: MetaCyc:RXN0-1141 is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016980 name: creatinase activity namespace: molecular_function def: "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea." [EC:3.5.3.3, RHEA:22456] synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3] xref: EC:3.5.3.3 xref: KEGG_REACTION:R01566 xref: MetaCyc:CREATINASE-RXN xref: RHEA:22456 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016984 name: ribulose-bisphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39] synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] synonym: "rubisco activity" EXACT [] synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] xref: EC:4.1.1.39 xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN xref: RHEA:23124 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0016985 name: mannan endo-1,4-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-1,4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase activity" BROAD [EC:3.2.1.78] synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-1,4-mannanase activity" BROAD [EC:3.2.1.78] synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-mannanase activity" BROAD [EC:3.2.1.78] xref: EC:3.2.1.78 xref: MetaCyc:3.2.1.78-RXN is_a: GO:0004567 ! beta-mannosidase activity [Term] id: GO:0016986 name: obsolete transcription initiation factor activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription initiation factor activity" EXACT [] synonym: "transcriptional initiation factor activity" EXACT [] is_obsolete: true consider: GO:0140223 [Term] id: GO:0016987 name: sigma factor activity namespace: molecular_function alt_id: GO:0000996 alt_id: GO:0001053 def: "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins." [GOC:txnOH-2018] comment: Updated for 2018 transcription branch review see https://github.com/geneontology/go-ontology/issues/15587 and https://github.com/geneontology/go-ontology/issues/14848 synonym: "bacterial sigma factor activity" NARROW [] synonym: "core DNA-dependent RNA polymerase binding promoter specificity activity" EXACT [] synonym: "DNA-dependent RNA polymerase promoter selection factor" EXACT [] synonym: "plastid sigma factor activity" NARROW [] synonym: "promoter selection factor activity" NARROW [] synonym: "sigma factor activity" EXACT [] synonym: "sigma transcription factor" EXACT [] is_a: GO:0140110 ! transcription regulator activity intersection_of: GO:0140110 ! transcription regulator activity intersection_of: has_part GO:0001046 ! core promoter sequence-specific DNA binding intersection_of: has_part GO:0043175 ! RNA polymerase core enzyme binding intersection_of: part_of GO:2000142 ! regulation of DNA-templated transcription, initiation relationship: has_part GO:0001046 ! core promoter sequence-specific DNA binding relationship: has_part GO:0043175 ! RNA polymerase core enzyme binding relationship: part_of GO:2000142 ! regulation of DNA-templated transcription, initiation created_by: kchris creation_date: 2010-08-11T04:12:24Z [Term] id: GO:0016988 name: obsolete transcription initiation factor antagonist activity namespace: molecular_function def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be. synonym: "transcription initiation factor antagonist activity" EXACT [] synonym: "transcriptional initiation factor antagonist activity" EXACT [] is_obsolete: true [Term] id: GO:0016989 name: sigma factor antagonist activity namespace: molecular_function def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors] synonym: "anti-sigma factor activity" EXACT [] is_a: GO:0003714 ! transcription corepressor activity [Term] id: GO:0016990 name: arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6] synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6] xref: EC:3.5.3.6 xref: MetaCyc:ARGININE-DEIMINASE-RXN xref: RHEA:19597 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines relationship: part_of GO:0018101 ! protein citrullination [Term] id: GO:0016992 name: lipoate synthase activity namespace: molecular_function alt_id: GO:0017140 def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109] synonym: "LipA" RELATED [EC:2.8.1.8] synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb] synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8] synonym: "LS" RELATED [EC:2.8.1.8] synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] xref: EC:2.8.1.8 xref: MetaCyc:RXN0-949 xref: Reactome:R-HSA-6793591 "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH" is_a: GO:0016783 ! sulfurtransferase activity relationship: part_of GO:0009107 ! lipoate biosynthetic process [Term] id: GO:0016993 name: precorrin-8X methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.99.61] synonym: "HBA synthase activity" EXACT [EC:5.4.99.61] synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.99.61] synonym: "precorrin isomerase activity" EXACT [EC:5.4.99.61] synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [] xref: EC:5.4.99.61 xref: MetaCyc:5.4.1.2-RXN xref: RHEA:22512 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0016994 name: precorrin-6A reductase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6X reductase activity" EXACT [] synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] xref: EC:1.3.1.54 xref: MetaCyc:1.3.1.54-RXN xref: RHEA:23408 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016995 name: cholesterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2." [EC:1.1.3.6, RHEA:21328] synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] xref: EC:1.1.3.6 xref: KEGG_REACTION:R01459 xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN xref: RHEA:21328 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0016996 name: endo-alpha-(2,8)-sialidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endosialidase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129] xref: EC:3.2.1.129 xref: MetaCyc:3.2.1.129-RXN is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0016997 name: alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016998 name: cell wall macromolecule catabolic process namespace: biological_process alt_id: GO:0044039 def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] synonym: "cell wall breakdown" RELATED [GOC:mah] synonym: "cell wall catabolism" RELATED [GOC:mah] synonym: "cell wall degradation" RELATED [GOC:mah] synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule catabolic process" EXACT [] synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0016999 name: antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] synonym: "antibiotic metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0017000 name: antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] subset: goslim_metagenomics synonym: "antibiotic anabolism" EXACT [] synonym: "antibiotic biosynthesis" EXACT [] synonym: "antibiotic formation" EXACT [] synonym: "antibiotic synthesis" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017001 name: antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] synonym: "antibiotic breakdown" EXACT [] synonym: "antibiotic catabolism" EXACT [] synonym: "antibiotic degradation" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017002 name: activin-activated receptor activity namespace: molecular_function def: "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "activin receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity relationship: has_part GO:0048185 ! activin binding relationship: part_of GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0017003 name: protein-heme linkage namespace: biological_process def: "The covalent linkage of heme and a protein." [GOC:ma] synonym: "protein-haem linkage" EXACT [] is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017004 name: cytochrome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] subset: goslim_metagenomics synonym: "cytochrome biogenesis" BROAD [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0017005 name: 3'-tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity [Term] id: GO:0017006 name: protein-tetrapyrrole linkage namespace: biological_process def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017007 name: protein-bilin linkage namespace: biological_process def: "The covalent linkage of bilin and a protein." [GOC:ai] is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017008 name: protein-phycobiliviolin linkage namespace: biological_process def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258] xref: RESID:AA0258 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017009 name: protein-phycocyanobilin linkage namespace: biological_process def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131] xref: RESID:AA0131 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017010 name: protein-phycourobilin linkage namespace: biological_process def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260] xref: RESID:AA0260 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017011 name: protein-phycoerythrobilin linkage namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259] xref: RESID:AA0132 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017012 name: protein-phytochromobilin linkage namespace: biological_process def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133] xref: RESID:AA0133 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017013 name: protein flavinylation namespace: biological_process def: "The addition of a flavin group to a protein amino acid." [GOC:ai] synonym: "protein amino acid flavinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017014 name: protein nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426] synonym: "protein amino acid nitrosylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017015 name: regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0017016 name: Ras GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ras interactor activity" RELATED [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0017017 name: MAP kinase tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity [Term] id: GO:0017018 name: myosin phosphatase activity namespace: molecular_function alt_id: GO:0017019 def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] synonym: "myosin phosphatase myosin binding" RELATED [] synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] xref: Reactome:R-HSA-390593 "ATP Hydrolysis By Myosin" xref: Reactome:R-HSA-445699 "ATP Hydrolysis By Myosin" is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0017020 name: myosin phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0017021 name: obsolete myosin phosphatase myosin binding namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function. synonym: "myosin phosphatase myosin binding" EXACT [] is_obsolete: true consider: GO:0017018 consider: GO:0017022 [Term] id: GO:0017022 name: myosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] synonym: "myosin phosphatase myosin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017023 name: myosin phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0017024 name: myosin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0017025 name: TBP-class protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867] synonym: "TATA-binding protein binding" NARROW [] synonym: "TBP binding" NARROW [] synonym: "TBP-related factor (TRF) protein binding" NARROW [] is_a: GO:0140296 ! general transcription initiation factor binding [Term] id: GO:0017026 name: obsolete procollagen C-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19] comment: This term was made obsolete because it represents a gene product. synonym: "BMP1" NARROW [] synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-endopeptidase activity" EXACT [] synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] xref: EC:3.4.24.19 xref: MetaCyc:3.4.24.19-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017027 name: obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "transmembrane receptor protein serine/threonine kinase receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017028 name: obsolete protein stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid, http://biotech.icmb.utexas.edu] comment: This term was made obsolete because it represents a biological process. synonym: "protein stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017029 name: obsolete lysosomal protein stabilization namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "lysosomal protein stabilization" EXACT [] is_obsolete: true consider: GO:0005764 consider: GO:0050821 [Term] id: GO:0017030 name: obsolete beta-galactosidase stabilization activity namespace: molecular_function def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "beta-galactosidase stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017032 name: amino acid:potassium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] synonym: "potassium:amino acid symporter activity" EXACT [] is_a: GO:0005416 ! amino acid:cation symporter activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity [Term] id: GO:0017034 name: Rap guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0017038 name: protein import namespace: biological_process def: "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] synonym: "protein uptake" EXACT [] is_a: GO:0015031 ! protein transport [Term] id: GO:0017039 name: obsolete dipeptidyl-peptidase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] comment: This term was made obsolete because it represents a gene product. synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl-peptidase III activity" EXACT [] synonym: "DPP III activity" EXACT [EC:3.4.14.4] synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] xref: EC:3.4.14.4 xref: MetaCyc:3.4.14.4-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017040 name: N-acylsphingosine amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23] synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23] xref: EC:3.5.1.23 xref: MetaCyc:CERAMIDASE-RXN xref: Reactome:R-HSA-1606583 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)" xref: Reactome:R-HSA-1606602 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)" xref: Reactome:R-HSA-428205 "ceramide + H2O => stearate + sphingosine [Golgi]" xref: Reactome:R-HSA-428231 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]" xref: RHEA:20856 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017041 name: galactosylgalactosylglucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47] synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47] synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] xref: EC:3.2.1.47 xref: MetaCyc:3.2.1.47-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0017042 name: glycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62] synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62] synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62] xref: EC:3.2.1.62 xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0017043 name: obsolete adrenocorticotropin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "adrenocorticotropin" EXACT [] synonym: "corticotropin" BROAD [] is_obsolete: true consider: GO:0005102 consider: GO:0046886 consider: GO:0046887 [Term] id: GO:0017044 name: melanocyte-stimulating hormone activity namespace: molecular_function def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732] synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "melanocyte stimulating hormone activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0017045 name: corticotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732] synonym: "adrenocorticotropin-releasing hormone" EXACT [] xref: Wikipedia:Corticotropin-releasing_hormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0017046 name: peptide hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732] synonym: "polypeptide hormone binding" EXACT [] is_a: GO:0042277 ! peptide binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0017048 name: Rho GTPase binding namespace: molecular_function alt_id: GO:0017031 def: "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856] synonym: "Rho interactor activity" RELATED [] synonym: "Rhophilin" NARROW [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017049 name: GTP-Rho binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTP-bound form of the Rho protein." [GOC:mah] is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0017050 name: D-erythro-sphingosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] synonym: "sphingosine kinase activity" EXACT [] xref: MetaCyc:RXN3DJ-11417 xref: Reactome:R-HSA-428273 "sphingosine +ATP => sphingosine 1-phosphate + ADP" xref: Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate" xref: Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation" is_a: GO:0016301 ! kinase activity [Term] id: GO:0017051 name: retinol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0017052 name: obsolete insulin-like growth factor binding protein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "insulin-like growth factor binding protein" EXACT [] is_obsolete: true consider: GO:0016942 [Term] id: GO:0017053 name: transcriptional repressor complex namespace: cellular_component def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] subset: goslim_pir synonym: "transcription factor inhibitor complex" EXACT [GOC:bhm] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0017054 name: negative cofactor 2 complex namespace: cellular_component def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0017055 name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly is_a: GO:0060633 ! negative regulation of transcription initiation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly relationship: negatively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly [Term] id: GO:0017056 name: structural constituent of nuclear pore namespace: molecular_function alt_id: GO:0005487 def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992] comment: Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively. synonym: "nuclear pore activity" RELATED [] synonym: "nucleocytoplasmic transporter activity" EXACT [] xref: Reactome:R-HSA-1176059 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus" xref: Reactome:R-HSA-170796 "NPC transports GCK1:GKRP from cytosol to nucleoplasm" xref: Reactome:R-HSA-192627 "Viral mRNA Export" xref: Reactome:R-HSA-192925 "Export of Spliced Viral mRNA" xref: Reactome:R-HSA-5252041 "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm" xref: Reactome:R-HSA-5578744 "Importin-8 imports AGO2:miRNA into the nucleus" xref: Reactome:R-HSA-5661474 "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm" xref: Reactome:R-HSA-6783483 "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol" xref: Reactome:R-HSA-75097 "Transport of the export-competent mRNP complex through the NPC" is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005643 ! nuclear pore relationship: occurs_in GO:0005643 ! nuclear pore relationship: part_of GO:0006913 ! nucleocytoplasmic transport created_by: tanyaberardini creation_date: 2015-06-29T08:59:16Z [Term] id: GO:0017057 name: 6-phosphogluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12556] synonym: "6-PGL" RELATED [EC:3.1.1.31] synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31] synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31] xref: EC:3.1.1.31 xref: KEGG_REACTION:R02035 xref: MetaCyc:6PGLUCONOLACT-RXN xref: Reactome:R-HSA-71296 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate" xref: RHEA:12556 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0017058 name: FH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017059 name: serine C-palmitoyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] is_a: GO:0031211 ! endoplasmic reticulum palmitoyltransferase complex [Term] id: GO:0017060 name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha(1,4)-L-fucosyltransferase activity" BROAD [] synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" BROAD [EC:2.4.1.65] synonym: "alpha-(1,4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "alpha-(1->4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "alpha-4-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood-group substance Lea-dependent fucosyltransferase" BROAD [EC:2.4.1.65] synonym: "FucT-II activity" BROAD [EC:2.4.1.65] synonym: "galactoside 3(4)-L-fucosyltransferase activity" BROAD [] synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "Lewis alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis FT activity" BROAD [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity" BROAD [] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] xref: EC:2.4.1.65 xref: MetaCyc:2.4.1.65-RXN xref: Reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc" xref: Reactome:R-HSA-9603986 "FUT3 transfers Fuc to Type 1 chains to form LeA" xref: RHEA:23628 is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0017061 name: S-methyl-5-thioadenosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTAPase activity" EXACT [EC:2.4.2.28] synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] xref: EC:2.4.2.28 xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN xref: Reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated" is_a: GO:0004731 ! purine-nucleoside phosphorylase activity [Term] id: GO:0017062 name: respiratory chain complex III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/] synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT [] synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT [] synonym: "complex III assembly" EXACT [] synonym: "complex III biogenesis" EXACT [] synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc] synonym: "cytochrome bc(1) complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0017063 name: obsolete phosphatidylserine-specific phospholipase A1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] comment: This term was made obsolete because the definition does not match the term name. synonym: "phosphatidylserine-specific phospholipase A1 activity" EXACT [] is_obsolete: true consider: GO:0052739 consider: GO:0052740 [Term] id: GO:0017064 name: fatty acid amide hydrolase activity namespace: molecular_function alt_id: GO:0017073 def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893] xref: Reactome:R-HSA-5693742 "FAAH hydrolyses AEA to AA and ETA" xref: Reactome:R-HSA-5693751 "FAAH2 hydrolyses AEA to AA and ETA" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017065 name: single-strand selective uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] xref: Reactome:R-HSA-110221 "Cleavage of uracil by SMUG1 glycosylase" is_a: GO:0004844 ! uracil DNA N-glycosylase activity [Term] id: GO:0017067 name: tyrosine-ester sulfotransferase activity namespace: molecular_function alt_id: GO:0008128 def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19977] synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "tyrosine-ester sulphotransferase activity" EXACT [] xref: EC:2.8.2.9 xref: KEGG_REACTION:R04213 xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN xref: RHEA:19977 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0017069 name: snRNA binding namespace: molecular_function alt_id: GO:0000945 def: "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah] synonym: "base pairing with snRNA" NARROW [] synonym: "small nuclear RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017070 name: U6 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0017071 name: intracellular cyclic nucleotide activated cation channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0017072 name: obsolete tubulin-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "tubulin-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0007021 [Term] id: GO:0017074 name: obsolete procollagen N-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14] comment: This term was made obsolete because it represents a gene product. synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-endopeptidase activity" EXACT [] synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "type III procollagen" RELATED [EC:3.4.24.14] xref: EC:3.4.24.14 xref: MetaCyc:3.4.24.14-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017075 name: syntaxin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-1." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0017076 name: purine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0017077 name: oxidative phosphorylation uncoupler activity namespace: molecular_function alt_id: GO:0015302 def: "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] synonym: "mitochondrial uncoupling protein activity" NARROW [] synonym: "uncoupling protein activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1902600 ! proton transmembrane transport [Term] id: GO:0017078 name: obsolete Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'. synonym: "Hsc70 interacting protein" BROAD [] synonym: "Hsc70 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0031072 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0017080 name: sodium channel regulator activity namespace: molecular_function def: "Modulates the activity of a sodium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity relationship: regulates GO:0005272 ! sodium channel activity [Term] id: GO:0017081 name: chloride channel regulator activity namespace: molecular_function def: "Modulates the activity of a chloride channel." [GOC:mah] xref: Reactome:R-HSA-383190 "HCO3- transport through ion channel" is_a: GO:0016247 ! channel regulator activity relationship: regulates GO:0005254 ! chloride channel activity [Term] id: GO:0017082 name: obsolete mineralocorticoid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876] comment: This term was obsoleted because it represents a gene product, see https://github.com/geneontology/go-ontology/issues/16732 synonym: "aldosterone receptor" NARROW [] is_obsolete: true [Term] id: GO:0017083 name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152] synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] xref: EC:2.4.1.152 xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity [Term] id: GO:0017084 name: delta1-pyrroline-5-carboxylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] xref: Reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0017085 name: response to insecticide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] synonym: "insecticide resistance" RELATED [] synonym: "insecticide susceptibility/resistance" RELATED [] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0017086 name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex namespace: cellular_component alt_id: GO:0031212 def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] synonym: "BCADH" EXACT [] synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0017087 name: mitochondrial processing peptidase complex namespace: cellular_component def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah] comment: Note that monomeric mitochondrial processing peptidases have been observed. is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017088 name: obsolete X-Pro dipeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] comment: This term was made obsolete because it represents a gene product. synonym: "PepX" RELATED [EC:3.4.14.11] synonym: "X-Pro dipeptidyl-peptidase activity" EXACT [] synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14.11 xref: MetaCyc:3.4.14.11-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017089 name: glycolipid transfer activity namespace: molecular_function def: "Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [PMID:30337668] synonym: "glycolipid carrier activity" EXACT [] synonym: "glycolipid transporter activity" BROAD [] synonym: "intermembrane glycolipid transfer activity" NARROW [] synonym: "intermembrane glycolipid transporter activity" NARROW [] xref: Reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane" is_a: GO:0120013 ! lipid transfer activity relationship: has_part GO:0051861 ! glycolipid binding relationship: part_of GO:0046836 ! glycolipid transport [Term] id: GO:0017090 name: meprin A complex namespace: cellular_component def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12] synonym: "PABA peptide hydrolase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0017091 name: AU-rich element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases." [GOC:bf, GOC:mah, PMID:7892223, PMID:8578590] synonym: "Adenylate/uridylate-rich element binding" EXACT [PMID:8578590] synonym: "ARE binding" EXACT [] synonym: "AU-specific RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017092 name: obsolete sterol regulatory element-binding protein site 2 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 2 protease activity" EXACT [] synonym: "sterol regulatory element-binding protein site 2 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008237 [Term] id: GO:0017093 name: obsolete sterol regulatory element-binding protein protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP protease activity" EXACT [] synonym: "sterol regulatory element-binding protein protease activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0017094 name: obsolete sterol regulatory element-binding protein site 1 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 1 protease activity" EXACT [] synonym: "sterol regulatory element-binding protein site 1 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008236 [Term] id: GO:0017095 name: heparan sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] synonym: "heparin 6-O-sulfotransferase activity" RELATED [] xref: EC:2.8.2 xref: Reactome:R-HSA-2076419 "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0017096 name: acetylserotonin O-methyltransferase activity namespace: molecular_function alt_id: GO:0017097 def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4] synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "acetylserotonin N-methyltransferase activity" RELATED [KEGG:2.1.1.4] synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] xref: EC:2.1.1.4 xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN xref: RHEA:15573 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017098 name: sulfonylurea receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] synonym: "sulfonylurea receptor ligand" NARROW [] synonym: "sulphonylurea receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0017099 name: very-long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:mah] synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT [] xref: EC:1.3.99 xref: Reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA" is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity [Term] id: GO:0017101 name: aminoacyl-tRNA synthetase multienzyme complex namespace: cellular_component def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] synonym: "aminoacyl-tRNA synthetase complex" EXACT [] synonym: "multisynthetase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0017102 name: methionyl glutamyl tRNA synthetase complex namespace: cellular_component def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0017103 name: UTP:galactose-1-phosphate uridylyltransferase activity namespace: molecular_function alt_id: GO:0003982 def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14209] synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] xref: EC:2.7.7.10 xref: KEGG_REACTION:R00502 xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN xref: RHEA:14209 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0017105 name: acyl-CoA delta11-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.5] synonym: "acyl-CoA D11-desaturase activity" EXACT [] synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] xref: EC:1.14.19.5 is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0017106 name: obsolete activin inhibitor activity namespace: molecular_function def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'. synonym: "activin inhibitor activity" EXACT [] is_obsolete: true consider: GO:0098772 [Term] id: GO:0017107 name: obsolete anion exchanger adaptor activity namespace: molecular_function def: "OBSOLETE. The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] comment: The term was made obsolete because it referred to an interaction of an anion transporter with the AP1 adaptor by which it is probably transported, see: PMID:22744004; PMID:20833140; ie the adaptor does not specifically target an anion adaptor. is_obsolete: true [Term] id: GO:0017108 name: 5'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] synonym: "5' flap endonuclease activity" EXACT [] xref: Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" xref: Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" xref: Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" xref: Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" xref: Reactome:R-HSA-69152 "Removal of remaining Flap" is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters is_a: GO:0048256 ! flap endonuclease activity [Term] id: GO:0017109 name: glutamate-cysteine ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0017110 name: nucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] synonym: "apyrase activity" BROAD [] synonym: "IDPase" NARROW [EC:3.6.1.6] synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] synonym: "NDPase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphatase activity" EXACT [] synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] xref: EC:3.6.1.6 xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN xref: Reactome:R-HSA-2395876 "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP" xref: Reactome:R-HSA-8850854 "NTPDase1 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851129 "NTPDase3 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017112 name: Rab guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A" xref: Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5" xref: Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10" xref: Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8" xref: Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9" xref: Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6" xref: Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12" xref: Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13" xref: Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14" xref: Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21" xref: Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27" xref: Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31" xref: Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7" xref: Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1" xref: Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35" xref: Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38" xref: Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39" xref: Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017137 ! Rab GTPase binding [Term] id: GO:0017113 name: dihydropyrimidine dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2] synonym: "DHPDH" RELATED [EC:1.3.1.2] synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2] synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2] synonym: "DPD" RELATED [EC:1.3.1.2] synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2] xref: EC:1.3.1.2 xref: MetaCyc:1.3.1.2-RXN xref: Reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+" xref: Reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+" xref: RHEA:18093 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0017114 name: obsolete wide-spectrum protease inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb] comment: This term was made obsolete because it represents a regulator of non-existent molecular function. synonym: "wide-spectrum protease inhibitor activity" EXACT [] synonym: "wide-spectrum proteinase inhibitor" EXACT [] is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0017116 name: single-stranded DNA helicase activity namespace: molecular_function alt_id: GO:0043142 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] synonym: "single-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT [] synonym: "single-stranded DNA-dependent ATPase activity" EXACT [] synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah] synonym: "ssDNA-dependent ATPase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0017117 name: single-stranded DNA-dependent ATP-dependent DNA helicase complex namespace: cellular_component def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah] is_a: GO:0033202 ! DNA helicase complex [Term] id: GO:0017118 name: lipoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0017119 name: Golgi transport complex namespace: cellular_component def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665] synonym: "COG complex" EXACT [] synonym: "conserved oligomeric Golgi complex" EXACT [] synonym: "Sec34/35 complex" NARROW [] is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0017120 name: obsolete polyphosphatidylinositol phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] comment: This term was made obsolete because it represents a gene product. synonym: "polyphosphatidylinositol phosphatase activity" EXACT [] synonym: "polyphosphoinositide phosphatase activity" EXACT [] is_obsolete: true consider: GO:0004438 consider: GO:0034593 consider: GO:0043812 [Term] id: GO:0017121 name: plasma membrane phospholipid scrambling namespace: biological_process def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864] comment: Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'. synonym: "phospholipid scrambling" RELATED [] synonym: "PL scrambling" EXACT [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0045332 ! phospholipid translocation [Term] id: GO:0017122 name: protein N-acetylglucosaminyltransferase complex namespace: cellular_component def: "A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits." [PMID:15247246] comment: Updated definition as suggested https://github.com/geneontology/go-ontology/issues/16994 synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0017124 name: SH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017125 name: deoxycytidyl transferase activity namespace: molecular_function alt_id: GO:0019986 def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] xref: Reactome:R-HSA-110308 "REV1 inserts dCMP opposite to AP sites in DNA" is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0017128 name: phospholipid scramblase activity namespace: molecular_function def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864] comment: Nomenclature note. Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Some authors however use the name floppase to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140303 ! intramembrane lipid transporter activity relationship: part_of GO:0017121 ! plasma membrane phospholipid scrambling [Term] id: GO:0017129 name: triglyceride binding namespace: molecular_function def: "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732] synonym: "triacylglycerol binding" EXACT [GOC:mah] is_a: GO:0008289 ! lipid binding [Term] id: GO:0017130 name: poly(C) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah] synonym: "poly(C) binding" BROAD [GOC:mah] synonym: "poly(rC) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017131 name: uridine-rich cytoplasmic polyadenylylation element binding namespace: molecular_function def: "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828] synonym: "U-rich CPE binding" EXACT [PMID:7954828] synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017132 name: cAMP-dependent guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase, when activated by cAMP binding." [GOC:mah, PMID:9856955] is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity relationship: has_part GO:0030552 ! cAMP binding [Term] id: GO:0017133 name: mitochondrial electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732] is_a: GO:0045251 ! electron transfer flavoprotein complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0045251 ! electron transfer flavoprotein complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017134 name: fibroblast growth factor binding namespace: molecular_function alt_id: GO:0048602 alt_id: GO:0048603 alt_id: GO:0048604 alt_id: GO:0048605 alt_id: GO:0048606 alt_id: GO:0048607 def: "Interacting selectively and non-covalently with a fibroblast growth factor." [PMID:9806903] synonym: "FGF 1 binding" NARROW [] synonym: "FGF 2 binding" NARROW [] synonym: "FGF 3 binding" NARROW [] synonym: "FGF 4 binding" NARROW [] synonym: "FGF 5 binding" NARROW [] synonym: "FGF 6 binding" NARROW [] synonym: "FGF binding" EXACT [] synonym: "fibroblast growth factor 1 binding" NARROW [] synonym: "fibroblast growth factor 2 binding" NARROW [] synonym: "fibroblast growth factor 3 binding" NARROW [] synonym: "fibroblast growth factor 4 binding" NARROW [] synonym: "fibroblast growth factor 5 binding" NARROW [] synonym: "fibroblast growth factor 6 binding" NARROW [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0017135 name: obsolete membrane-associated protein with guanylate kinase activity interacting namespace: molecular_function def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005] comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense. synonym: "membrane-associated protein with guanylate kinase activity interacting" EXACT [] is_obsolete: true consider: GO:0019899 [Term] id: GO:0017136 name: NAD-dependent histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24548] synonym: "SIR2" RELATED [] is_a: GO:0004407 ! histone deacetylase activity is_a: GO:0034979 ! NAD-dependent protein deacetylase activity [Term] id: GO:0017137 name: Rab GTPase binding namespace: molecular_function alt_id: GO:0005084 def: "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Rab escort protein activity" NARROW [] synonym: "Rab interactor activity" RELATED [] synonym: "REP" NARROW [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017139 name: obsolete arsenate sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "arsenate sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046685 [Term] id: GO:0017141 name: obsolete antibiotic susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "antibiotic susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046677 [Term] id: GO:0017142 name: obsolete toxin susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "toxin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0017143 name: insecticide metabolic process namespace: biological_process alt_id: GO:0017138 def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] synonym: "insecticide metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009404 ! toxin metabolic process relationship: part_of GO:0017085 ! response to insecticide [Term] id: GO:0017144 name: drug metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "drug metabolism" EXACT [] xref: Wikipedia:Drug_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division [Term] id: GO:0017146 name: NMDA selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] synonym: "N-methyl-D-aspartate selective glutamate receptor complex" EXACT [] synonym: "NMDA-selective glutamate receptor" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034703 ! cation channel complex [Term] id: GO:0017147 name: Wnt-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process alt_id: GO:0016478 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006412 ! translation relationship: negatively_regulates GO:0006412 ! translation [Term] id: GO:0017149 name: obsolete protein biosynthetic process inhibitor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "protein anabolism inhibitor activity" EXACT [] synonym: "protein biosynthetic process inhibitor activity" EXACT [] synonym: "protein formation inhibitor activity" EXACT [] synonym: "protein synthesis inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0017148 [Term] id: GO:0017150 name: tRNA dihydrouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] xref: MetaCyc:RXN0-1281 xref: Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0002943 ! tRNA dihydrouridine synthesis [Term] id: GO:0017151 name: DEAD/H-box RNA helicase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0017153 name: sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] synonym: "sodium:dicarboxylate cotransporter activity" BROAD [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0005343 ! organic acid:sodium symporter activity [Term] id: GO:0017154 name: semaphorin receptor activity namespace: molecular_function def: "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0071526 ! semaphorin-plexin signaling pathway [Term] id: GO:0017155 name: obsolete sodium:hydrogen antiporter regulator activity namespace: molecular_function alt_id: GO:0030040 def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a biological process. synonym: "sodium:hydrogen antiporter regulator activity" EXACT [] synonym: "sodium:proton antiporter regulator" EXACT [] is_obsolete: true [Term] id: GO:0017156 name: calcium-ion regulated exocytosis namespace: biological_process def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators] comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway. synonym: "calcium ion-dependent exocytosis" EXACT [] is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006887 ! exocytosis relationship: regulates GO:0006887 ! exocytosis [Term] id: GO:0017158 name: regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017156 ! calcium-ion regulated exocytosis relationship: regulates GO:0017156 ! calcium-ion regulated exocytosis [Term] id: GO:0017159 name: pantetheine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13445] synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92] synonym: "pantetheinase activity" EXACT [EC:3.5.1.92] synonym: "vanin" RELATED [EC:3.5.1.92] synonym: "vanin-1" RELATED [EC:3.5.1.92] xref: EC:3.5.1.92 xref: KEGG_REACTION:R02973 xref: MetaCyc:3.5.1.92-RXN xref: Reactome:R-HSA-8938300 "Vanin hydrolyses pantetheine to PanK, 2AET" xref: RHEA:13445 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017160 name: Ral GTPase binding namespace: molecular_function alt_id: GO:0034989 def: "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "GTP-Ral binding" NARROW [] synonym: "Ral interactor activity" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017161 name: inositol-1,3,4-trisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol" is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0017162 name: aryl hydrocarbon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an aryl hydrocarbon receptor." [GOC:ai] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0017163 name: obsolete basal transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "basal transcription repressor activity" EXACT [] is_obsolete: true consider: GO:0001217 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0017164 name: obsolete nicotinic acetylcholine receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "nicotinic acetylcholine receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017165 name: obsolete dipeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-aspartyl dipeptidase activity" EXACT [] synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] synonym: "dipeptidase E activity" EXACT [] synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] synonym: "peptidase E activity" BROAD [EC:3.4.13.21] xref: EC:3.4.13.21 xref: MetaCyc:3.4.13.21-RXN is_obsolete: true replaced_by: GO:0016805 [Term] id: GO:0017166 name: vinculin binding namespace: molecular_function def: "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017168 name: 5-oxoprolinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10348] synonym: "5-OPase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9] xref: EC:3.5.2.9 xref: KEGG_REACTION:R00251 xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN xref: Reactome:R-HSA-1247935 "OPLAH hydrolyses OPRO to L-Glu" xref: Reactome:R-HSA-5603208 "Defective OPLAH does not hydrolyse OPRO" xref: RHEA:10348 xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0017169 name: CDP-alcohol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0017170 name: obsolete KU70 binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "KU70 binding" EXACT [] is_obsolete: true [Term] id: GO:0017171 name: serine hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase] is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds [Term] id: GO:0017172 name: cysteine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20441] xref: EC:1.13.11.20 xref: KEGG_REACTION:R00893 xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN xref: Reactome:R-HSA-1614645 "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine" xref: RHEA:20441 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0017174 name: glycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "GNMT" RELATED [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20] xref: EC:2.1.1.156 xref: EC:2.1.1.162 xref: EC:2.1.1.20 xref: KEGG_REACTION:R00367 xref: MetaCyc:2.1.1.162-RXN xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-6798317 "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC" xref: RHEA:19937 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017175 name: obsolete IMP-GMP specific 5'-nucleotidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc] comment: This term was made obsolete because it represents a gene product with two different activities. synonym: "IMP-GMP specific 5'-nucleotidase activity" EXACT [] is_obsolete: true consider: GO:0050484 [Term] id: GO:0017176 name: phosphatidylinositol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] xref: EC:2.4.1.198 xref: MetaCyc:2.4.1.198-RXN xref: RHEA:14789 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0017177 name: glucosidase II complex namespace: cellular_component def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. synonym: "alpha-glucosidase II complex" RELATED [GOC:19605557, GOC:vw] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0017178 name: diphthine-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate." [EC:6.3.1.14, RHEA:19753] synonym: "diphthamide synthase activity" EXACT [EC:6.3.1.14] synonym: "diphthamide synthetase activity" EXACT [EC:6.3.1.14] synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.14] xref: EC:6.3.1.14 xref: KEGG_REACTION:R03613 xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN xref: Reactome:R-HSA-5358475 "DPH6 ligates ammonium to diphthine-EEF2" xref: RHEA:19753 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0017179 name: peptidyl-diphthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthine metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017180 name: peptidyl-diphthine biosynthetic process from peptidyl-histidine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators] synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017181 name: peptidyl-diphthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthine breakdown" EXACT [] synonym: "peptidyl-diphthine catabolism" EXACT [] synonym: "peptidyl-diphthine degradation" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017182 name: peptidyl-diphthamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthamide metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017183 name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine namespace: biological_process def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT [] xref: RESID:AA0040 is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1900247 ! regulation of cytoplasmic translational elongation [Term] id: GO:0017184 name: peptidyl-diphthamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthamide breakdown" EXACT [] synonym: "peptidyl-diphthamide catabolism" EXACT [] synonym: "peptidyl-diphthamide degradation" EXACT [] is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017185 name: peptidyl-lysine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0017186 name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT [] synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT [] synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT [] xref: RESID:AA0031 is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017187 name: peptidyl-glutamic acid carboxylation namespace: biological_process def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. xref: RESID:AA0032 is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0017188 name: aspartate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14165] synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] xref: EC:2.3.1.17 xref: KEGG_REACTION:R00487 xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-8954468 "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA" xref: RHEA:14165 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0017189 name: N-terminal peptidyl-alanine acetylation namespace: biological_process def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041] comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. xref: RESID:AA0041 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0017190 name: N-terminal peptidyl-aspartic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. xref: RESID:AA0042 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0017192 name: N-terminal peptidyl-glutamine acetylation namespace: biological_process def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045] xref: RESID:AA0045 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017193 name: N-terminal peptidyl-glycine acetylation namespace: biological_process def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046] xref: RESID:AA0046 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0017194 name: N-terminal peptidyl-isoleucine acetylation namespace: biological_process def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047] xref: RESID:AA0047 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0017195 name: N-terminal peptidyl-lysine N2-acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048] xref: RESID:AA0048 is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation [Term] id: GO:0017196 name: N-terminal peptidyl-methionine acetylation namespace: biological_process def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049] xref: RESID:AA0049 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0017197 name: N-terminal peptidyl-proline acetylation namespace: biological_process def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050] xref: RESID:AA0050 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0017198 name: N-terminal peptidyl-serine acetylation namespace: biological_process def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051] xref: RESID:AA0051 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0017199 name: N-terminal peptidyl-threonine acetylation namespace: biological_process def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052] comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. xref: RESID:AA0052 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018000 name: N-terminal peptidyl-tyrosine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053] xref: RESID:AA0053 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018001 name: N-terminal peptidyl-valine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054] xref: RESID:AA0054 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018002 name: N-terminal peptidyl-glutamic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. xref: RESID:AA0044 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018003 name: peptidyl-lysine N6-acetylation namespace: biological_process def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055] comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. xref: RESID:AA0055 is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0018004 name: N-terminal protein formylation namespace: biological_process def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai] is_a: GO:0018256 ! protein formylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018005 name: N-terminal peptidyl-glycine N-formylation namespace: biological_process def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057] xref: RESID:AA0057 is_a: GO:0018004 ! N-terminal protein formylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018006 name: N-terminal protein amino acid glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai] is_a: GO:0018321 ! protein glucuronylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018007 name: N-terminal peptidyl-glycine N-glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058] xref: RESID:AA0058 is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018008 name: N-terminal peptidyl-glycine N-myristoylation namespace: biological_process def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059] synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT [] xref: RESID:AA0059 is_a: GO:0006499 ! N-terminal protein myristoylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018009 name: N-terminal peptidyl-L-cysteine N-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060] xref: RESID:AA0060 is_a: GO:0006500 ! N-terminal protein palmitoylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018010 name: glycoprotein N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96] xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN is_a: GO:0019105 ! N-palmitoyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0018011 name: N-terminal peptidyl-alanine methylation namespace: biological_process def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062] xref: RESID:AA0061 xref: RESID:AA0062 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018012 name: N-terminal peptidyl-alanine trimethylation namespace: biological_process def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062] xref: RESID:AA0062 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0018013 name: N-terminal peptidyl-glycine methylation namespace: biological_process def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063] xref: RESID:AA0063 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018014 name: N-terminal peptidyl-methionine methylation namespace: biological_process def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064] xref: RESID:AA0064 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018015 name: N-terminal peptidyl-phenylalanine methylation namespace: biological_process def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065] xref: RESID:AA0065 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018016 name: N-terminal peptidyl-proline dimethylation namespace: biological_process def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066] xref: RESID:AA0066 is_a: GO:0035568 ! N-terminal peptidyl-proline methylation [Term] id: GO:0018019 name: N-terminal peptidyl-glutamine methylation namespace: biological_process def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071] xref: RESID:AA0071 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018020 name: peptidyl-glutamic acid methylation namespace: biological_process def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation [Term] id: GO:0018021 name: peptidyl-histidine methylation namespace: biological_process def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317] xref: RESID:AA0073 xref: RESID:AA0317 is_a: GO:0006479 ! protein methylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018022 name: peptidyl-lysine methylation namespace: biological_process def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] is_a: GO:0006479 ! protein methylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018023 name: peptidyl-lysine trimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] xref: RESID:AA0074 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018024 name: histone-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah] synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] xref: EC:2.1.1.43 xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-3788745 "EHMT1:EHMT2 methylates IL8 promoter" xref: Reactome:R-HSA-3788748 "EHMT1:EHMT2 methylates IL6 promoter" xref: Reactome:R-HSA-4827382 "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)" xref: Reactome:R-HSA-4827383 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)" xref: Reactome:R-HSA-5159245 "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)" xref: Reactome:R-HSA-5244692 "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)" xref: Reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)" xref: Reactome:R-HSA-5634729 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)" xref: Reactome:R-HSA-5634750 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)" xref: Reactome:R-HSA-5634802 "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)" xref: Reactome:R-HSA-5637686 "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)" xref: Reactome:R-HSA-5638141 "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)" xref: Reactome:R-HSA-5638157 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)" xref: Reactome:R-HSA-5638332 "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)" xref: Reactome:R-HSA-5638333 "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)" xref: Reactome:R-HSA-5649764 "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)" xref: Reactome:R-HSA-5649799 "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)" xref: Reactome:R-HSA-5649800 "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)" xref: Reactome:R-HSA-5649801 "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)" xref: Reactome:R-HSA-5649802 "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)" xref: Reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)" xref: Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)" xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity relationship: part_of GO:0034968 ! histone lysine methylation [Term] id: GO:0018025 name: calmodulin-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60] xref: EC:2.1.1.60 xref: MetaCyc:2.1.1.60-RXN xref: Reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1" is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0018026 name: peptidyl-lysine monomethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] xref: RESID:AA0076 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018027 name: peptidyl-lysine dimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] xref: RESID:AA0075 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018028 name: peptidyl-lysine myristoylation namespace: biological_process def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078] synonym: "peptidyl-lysine myristylation" EXACT [] xref: RESID:AA0078 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0018029 name: peptidyl-lysine palmitoylation namespace: biological_process def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077] xref: RESID:AA0077 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018030 name: peptidyl-lysine N6-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0018031 name: peptidyl-lysine N6-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] xref: EC:2.3.1 is_a: GO:0019105 ! N-palmitoyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0018032 name: protein amidation namespace: biological_process def: "Addition of an amide group from a glycine to a protein amino acid." [UniProtKB-KW:KW-0027] synonym: "protein amino acid amidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018033 name: protein C-terminal amidation namespace: biological_process def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai] is_a: GO:0018032 ! protein amidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018034 name: C-terminal peptidyl-alanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081] xref: RESID:AA0081 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018035 name: C-terminal peptidyl-arginine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082] xref: RESID:AA0082 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018036 name: C-terminal peptidyl-asparagine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083] xref: RESID:AA0083 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018037 name: C-terminal peptidyl-aspartic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084] xref: RESID:AA0084 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018038 name: C-terminal peptidyl-cysteine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085] xref: RESID:AA0085 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018039 name: C-terminal peptidyl-glutamine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086] xref: RESID:AA0086 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018040 name: C-terminal peptidyl-glutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087] xref: RESID:AA0087 is_a: GO:0018033 ! protein C-terminal amidation [Term] id: GO:0018041 name: C-terminal peptidyl-glycine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088] xref: RESID:AA0088 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018042 name: C-terminal peptidyl-histidine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089] xref: RESID:AA0089 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018043 name: C-terminal peptidyl-isoleucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090] xref: RESID:AA0090 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0018044 name: C-terminal peptidyl-leucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091] xref: RESID:AA0091 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018204 ! peptidyl-leucine modification [Term] id: GO:0018045 name: C-terminal peptidyl-lysine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092] xref: RESID:AA0092 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018046 name: C-terminal peptidyl-methionine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093] xref: RESID:AA0093 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018047 name: C-terminal peptidyl-phenylalanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094] xref: RESID:AA0094 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018048 name: C-terminal peptidyl-proline amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095] xref: RESID:AA0095 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018049 name: C-terminal peptidyl-serine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096] xref: RESID:AA0096 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018050 name: C-terminal peptidyl-threonine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097] xref: RESID:AA0097 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018051 name: C-terminal peptidyl-tryptophan amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098] xref: RESID:AA0098 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018052 name: C-terminal peptidyl-tyrosine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099] xref: RESID:AA0099 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018053 name: C-terminal peptidyl-valine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100] xref: RESID:AA0100 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018054 name: peptidyl-lysine biotinylation namespace: biological_process def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] xref: RESID:AA0117 is_a: GO:0009305 ! protein biotinylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018057 name: peptidyl-lysine oxidation namespace: biological_process def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121] xref: RESID:AA0121 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018058 name: N-terminal protein amino acid deamination, from amino carbon namespace: biological_process def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129] xref: RESID:AA0127 xref: RESID:AA0128 xref: RESID:AA0129 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018277 ! protein deamination is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0018059 name: N-terminal peptidyl-serine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018060 name: N-terminal peptidyl-cysteine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018061 name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine namespace: biological_process def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128] synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT [] xref: RESID:AA0128 is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018062 name: peptidyl-tryptophan succinylation namespace: biological_process def: "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130] xref: RESID:AA0130 is_a: GO:0018211 ! peptidyl-tryptophan modification is_a: GO:0018335 ! protein succinylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018063 name: cytochrome c-heme linkage namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135] synonym: "cytochrome c-haem linkage" EXACT [] xref: RESID:AA0134 xref: RESID:AA0135 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018064 name: protein-histidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85] synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] xref: EC:2.1.1.85 xref: MetaCyc:2.1.1.85-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018065 name: protein-cofactor linkage namespace: biological_process def: "The covalent attachment of a cofactor to a protein." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018067 name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0146 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018068 name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147] synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0147 is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018069 name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149] xref: RESID:AA0149 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018070 name: peptidyl-serine phosphopantetheinylation namespace: biological_process def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150] xref: RESID:AA0150 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018215 ! protein phosphopantetheinylation [Term] id: GO:0018071 name: NAD(P)-cysteine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018072 name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid namespace: biological_process def: "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT [] xref: RESID:AA0170 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018073 name: protein bromination namespace: biological_process def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah] synonym: "protein amino acid bromination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018074 name: peptidyl-histidine bromination namespace: biological_process def: "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173] xref: RESID:AA0173 is_a: GO:0018073 ! protein bromination is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018075 name: peptidyl-phenylalanine bromination namespace: biological_process def: "The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176] xref: RESID:AA0174 xref: RESID:AA0175 xref: RESID:AA0176 is_a: GO:0018073 ! protein bromination is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018076 name: N-terminal peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai] is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018077 name: protein iodination namespace: biological_process def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah] synonym: "protein amino acid iodination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018078 name: peptidyl-thyronine iodination namespace: biological_process def: "The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178] xref: RESID:AA0177 xref: RESID:AA0178 is_a: GO:0018077 ! protein iodination is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018079 name: protein halogenation namespace: biological_process def: "The addition of a halogen to a protein amino acid." [GOC:ai] synonym: "protein amino acid halogenation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0070276 ! halogen metabolic process [Term] id: GO:0018080 name: peptidyl-tryptophan bromination namespace: biological_process def: "The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179] xref: RESID:AA0179 is_a: GO:0018073 ! protein bromination is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018081 name: peptide cross-linking via lanthionine or 3-methyl-lanthionine namespace: biological_process def: "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112] synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT [] synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT [] xref: RESID:AA0110 xref: RESID:AA0111 xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018082 name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine namespace: biological_process def: "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182] synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT [] xref: RESID:AA0182 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018083 name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine namespace: biological_process def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185] synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT [] xref: RESID:AA0185 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018084 name: peptidyl-lactic acid biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186] synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0186 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018085 name: peptidyl-L-amino acid racemization namespace: biological_process def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification is_a: GO:0018366 ! chiral amino acid racemization [Term] id: GO:0018086 name: obsolete alanine racemization namespace: biological_process alt_id: GO:0018368 def: "OBSOLETE. (Was not defined before being made obsolete)." [RESID:AA0191] comment: This term was made obsolete because it was replaced with more appropriate terms. synonym: "alanine racemization" EXACT [] is_obsolete: true consider: GO:0019122 [Term] id: GO:0018091 name: peptidyl-asparagine racemization namespace: biological_process alt_id: GO:0018373 alt_id: GO:0019127 def: "The racemization of peptidyl-asparagine." [RESID:AA0196] xref: RESID:AA0196 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018094 name: protein polyglycylation namespace: biological_process def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] xref: RESID:AA0201 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018095 name: protein polyglutamylation namespace: biological_process def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] xref: RESID:AA0202 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018096 name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine namespace: biological_process def: "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204] xref: RESID:AA0204 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018097 name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine namespace: biological_process def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207] synonym: "protein amino acid cinnamylation" BROAD [] xref: RESID:AA0207 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018101 name: protein citrullination namespace: biological_process def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [PMID:23175390, RESID:AA0214] comment: Citrullination is distinct from the formation of the free amino acid citrulline (e.g. as part of the urea cycle). synonym: "deimination" EXACT [Wikipedia:Citrullination] synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline biosynthetic process from peptidyl-arginine" EXACT [RESID:AA0214] synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT [] xref: RESID:AA0214 is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018102 name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215] xref: RESID:AA0215 is_a: GO:0018126 ! protein hydroxylation is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0018103 name: protein C-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217] synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0217 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018104 name: peptidoglycan-protein cross-linking namespace: biological_process def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg] is_a: GO:0009252 ! peptidoglycan biosynthetic process [Term] id: GO:0018105 name: peptidyl-serine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] xref: RESID:AA0037 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018106 name: peptidyl-histidine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036] xref: RESID:AA0035 xref: RESID:AA0036 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018107 name: peptidyl-threonine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] xref: RESID:AA0038 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018108 name: peptidyl-tyrosine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] xref: RESID:AA0039 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018109 name: peptidyl-arginine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222] xref: RESID:AA0222 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018110 name: histone arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah] synonym: "histone-arginine kinase activity" EXACT [] xref: EC:2.7.3 is_a: GO:0004054 ! arginine kinase activity is_a: GO:0035173 ! histone kinase activity relationship: part_of GO:0018109 ! peptidyl-arginine phosphorylation [Term] id: GO:0018111 name: methionine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12492] xref: EC:5.1.1.2 xref: KEGG_REACTION:R00655 xref: MetaCyc:METHIONINE-RACEMASE-RXN xref: RHEA:12492 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018112 name: proline racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10680] xref: EC:5.1.1.4 xref: KEGG_REACTION:R01255 xref: MetaCyc:PROLINE-RACEMASE-RXN xref: RHEA:10680 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018113 name: lysine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] xref: EC:5.1.1.5 xref: MetaCyc:LYSINE-RACEMASE-RXN xref: RHEA:22864 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018114 name: threonine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13913] xref: EC:5.1.1.6 xref: KEGG_REACTION:R01467 xref: MetaCyc:THREONINE-RACEMASE-RXN xref: RHEA:13913 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018115 name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0223 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018116 name: peptidyl-lysine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227] synonym: "peptidyl-lysine adenylation" EXACT [] xref: RESID:AA0227 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018117 name: protein adenylylation namespace: biological_process alt_id: GO:0018176 def: "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083] synonym: "protein adenylation" EXACT [] synonym: "protein amino acid adenylylation" EXACT [GOC:bf] synonym: "protein AMPylation" EXACT [GOC:jsg, GOC:sart, PMID:21607083] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018118 name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229] synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0229 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018119 name: peptidyl-cysteine S-nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230] synonym: "protein S-nitrosylation" EXACT [PMID:20972426] synonym: "S-nitrosylation" EXACT [PMID:20972426] xref: RESID:AA0230 is_a: GO:0017014 ! protein nitrosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018120 name: peptidyl-arginine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168] xref: RESID:AA0168 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018121 name: NAD(P)-asparagine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018122 name: peptidyl-asparagine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231] xref: RESID:AA0231 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018123 name: peptidyl-cysteine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169] xref: RESID:AA0169 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018124 name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone namespace: biological_process def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233] xref: RESID:AA0233 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018125 name: peptidyl-cysteine methylation namespace: biological_process def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234] xref: RESID:AA0234 is_a: GO:0006479 ! protein methylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018126 name: protein hydroxylation namespace: biological_process def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] synonym: "protein amino acid hydroxylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.09 is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018127 name: NAD(P)-serine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018128 name: obsolete peptidyl-serine cyclase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "peptidyl-serine cyclase activity" EXACT [] xref: EC:4.2.1 is_obsolete: true [Term] id: GO:0018129 name: peptidyl-oxazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018131 name: oxazole or thiazole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators] synonym: "oxazole or thiazole anabolism" EXACT [] synonym: "oxazole or thiazole biosynthesis" EXACT [] synonym: "oxazole or thiazole formation" EXACT [] synonym: "oxazole or thiazole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046484 ! oxazole or thiazole metabolic process [Term] id: GO:0018132 name: peptide cross-linking via L-cysteine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238] xref: RESID:AA0238 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018133 name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239] xref: RESID:AA0239 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018134 name: peptide cross-linking via glycine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240] xref: RESID:AA0240 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018135 name: obsolete peptidyl-cysteine cyclase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "peptidyl-cysteine cyclase activity" EXACT [] xref: EC:4.2.1 is_obsolete: true [Term] id: GO:0018136 name: peptidyl-thiazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018137 name: peptide cross-linking via glycine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241] xref: RESID:AA0241 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018138 name: peptide cross-linking via L-serine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242] xref: RESID:AA0242 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018139 name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243] xref: RESID:AA0243 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018140 name: peptide cross-linking via L-cysteine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244] xref: RESID:AA0244 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018141 name: peptide cross-linking via L-lysine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245] xref: RESID:AA0245 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018142 name: protein-DNA covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma] synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah] is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018143 name: nucleic acid-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018144 name: RNA-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma] is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018145 name: protein-DNA covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246] synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah] xref: RESID:AA0246 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018146 name: keratan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247] synonym: "keratan sulfate anabolism" EXACT [] synonym: "keratan sulfate biosynthesis" EXACT [] synonym: "keratan sulfate formation" EXACT [] synonym: "keratan sulfate synthesis" EXACT [] synonym: "keratan sulphate biosynthesis" EXACT [] synonym: "keratan sulphate biosynthetic process" EXACT [] xref: RESID:AA0247 is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0042339 ! keratan sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0018147 name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248] xref: RESID:AA0248 is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0018148 name: RNA-protein covalent cross-linking via peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249] xref: RESID:AA0249 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018149 name: peptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018150 name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250] xref: RESID:AA0250 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018151 name: peptide cross-linking via L-histidyl-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai] is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018152 name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270] xref: RESID:AA0270 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018153 name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124] xref: RESID:AA0124 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018154 name: peptide cross-linking via (2R,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110] xref: RESID:AA0110 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018155 name: peptide cross-linking via sn-(2S,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111] xref: RESID:AA0111 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018156 name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112] xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018157 name: peptide cross-linking via an oxazole or thiazole namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg] synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah] synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah] synonym: "peptide heterocycle formation" RELATED [GOC:mah] synonym: "peptide heterocycle synthesis" RELATED [GOC:mah] is_a: GO:0018131 ! oxazole or thiazole biosynthetic process is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018158 name: protein oxidation namespace: biological_process def: "The modification of a protein amino acid by oxidation." [GOC:ai] synonym: "protein amino acid oxidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0018159 name: peptidyl-methionine oxidation namespace: biological_process def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251] xref: RESID:AA0251 is_a: GO:0018158 ! protein oxidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018160 name: peptidyl-pyrromethane cofactor linkage namespace: biological_process alt_id: GO:0018354 alt_id: GO:0033035 def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [RESID:AA0252] synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg] synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg] xref: RESID:AA0252 is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018161 name: dipyrrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] synonym: "dipyrrin anabolism" EXACT [] synonym: "dipyrrin biosynthesis" EXACT [] synonym: "dipyrrin formation" EXACT [] synonym: "dipyrrin synthesis" EXACT [] synonym: "dipyrromethane biosynthesis" EXACT [] synonym: "dipyrromethane biosynthetic process" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046453 ! dipyrrin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0018162 name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine namespace: biological_process def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253] xref: RESID:AA0253 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018163 name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254] synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah] xref: RESID:AA0254 is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine [Term] id: GO:0018164 name: protein-DNA covalent cross-linking via peptidyl-threonine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255] synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah] xref: RESID:AA0255 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018165 name: peptidyl-tyrosine uridylylation namespace: biological_process def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256] xref: RESID:AA0256 is_a: GO:0018177 ! protein uridylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018166 name: C-terminal protein-tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257] comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. xref: RESID:AA0257 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018322 ! protein tyrosinylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018167 name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259] xref: RESID:AA0259 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018168 name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132] xref: RESID:AA0132 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018169 name: ribosomal S6-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347] is_a: GO:0070739 ! protein-glutamic acid ligase activity [Term] id: GO:0018170 name: C-terminal peptidyl-polyglutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261] xref: RESID:AA0261 is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018171 name: peptidyl-cysteine oxidation namespace: biological_process def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262] xref: RESID:AA0205 xref: RESID:AA0262 is_a: GO:0018158 ! protein oxidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018172 name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0263 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018173 name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0265 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process [Term] id: GO:0018174 name: protein-heme P460 linkage namespace: biological_process def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271] synonym: "protein-haem P460 linkage" EXACT [] xref: RESID:AA0266 xref: RESID:AA0271 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018175 name: protein nucleotidylation namespace: biological_process def: "The addition of a nucleotide to a protein amino acid." [GOC:ai] synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018177 name: protein uridylylation namespace: biological_process def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg] synonym: "protein amino acid uridylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018178 name: peptidyl-threonine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267] synonym: "peptidyl-threonine adenylation" EXACT [] xref: RESID:AA0267 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018179 name: obsolete peptidyl-cysteine desulfurization namespace: biological_process def: "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269] comment: This term was made obsolete because to does not correspond to a real process. synonym: "peptidyl-cysteine desulfurization" EXACT [] synonym: "peptidyl-cysteine desulphurization" EXACT [] xref: RESID:AA0269 is_obsolete: true [Term] id: GO:0018180 name: protein desulfurization namespace: biological_process def: "The removal of a sulfur group from a protein amino acid." [GOC:ai] synonym: "protein amino acid desulfurisation" EXACT [] synonym: "protein amino acid desulfurization" EXACT [GOC:bf] synonym: "protein amino acid desulphurisation" EXACT [] synonym: "protein amino acid desulphurization" EXACT [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018181 name: peptidyl-arginine C5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272] synonym: "peptidyl-arginine 5-methylation" EXACT [] xref: RESID:AA0272 is_a: GO:0035245 ! peptidyl-arginine C-methylation [Term] id: GO:0018182 name: protein-heme linkage via 3'-L-histidine namespace: biological_process def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276] synonym: "protein-haem linkage via 3'-L-histidine" EXACT [] xref: RESID:AA0276 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018183 name: obsolete enzyme active site formation via S-selenyl-L-cysteine namespace: biological_process def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277] comment: This term was made obsolete because this structure does not exist. synonym: "enzyme active site formation via S-selenyl-L-cysteine" EXACT [] is_obsolete: true [Term] id: GO:0018184 name: protein polyamination namespace: biological_process def: "The modification of a protein amino acid by polyamination." [GOC:ai] synonym: "protein amino acid polyamination" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018185 name: poly-N-methyl-propylamination namespace: biological_process def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278] xref: RESID:AA0278 is_a: GO:0018184 ! protein polyamination is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018186 name: peroxidase-heme linkage namespace: biological_process def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280] synonym: "peroxidase-haem linkage" EXACT [] xref: RESID:AA0279 xref: RESID:AA0280 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018187 name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281] xref: RESID:AA0281 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018188 name: peptidyl-proline di-hydroxylation namespace: biological_process def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282] xref: RESID:AA0282 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018189 name: pyrroloquinoline quinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283] synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT [] synonym: "PQQ biosynthesis" EXACT [] synonym: "PQQ biosynthetic process" EXACT [] synonym: "pyrroloquinoline quinone anabolism" EXACT [] synonym: "pyrroloquinoline quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline quinone formation" EXACT [] synonym: "pyrroloquinoline quinone synthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] xref: RESID:AA0283 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0018190 name: protein octanoylation namespace: biological_process def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg] synonym: "protein amino acid octanoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018191 name: peptidyl-serine octanoylation namespace: biological_process def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290] xref: RESID:AA0290 is_a: GO:0018190 ! protein octanoylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018192 name: enzyme active site formation via cysteine modification to L-cysteine persulfide namespace: biological_process def: "The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269] synonym: "enzyme active site formation via L-cysteine persulphide" EXACT [] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098822 ! peptidyl-cysteine modification to L-cysteine persulfide [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: goslim_yeast is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018194 name: peptidyl-alanine modification namespace: biological_process def: "The modification of peptidyl-alanine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018195 name: peptidyl-arginine modification namespace: biological_process def: "The modification of peptidyl-arginine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018196 name: peptidyl-asparagine modification namespace: biological_process def: "The modification of peptidyl-asparagine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018197 name: peptidyl-aspartic acid modification namespace: biological_process def: "The modification of peptidyl-aspartic acid." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018198 name: peptidyl-cysteine modification namespace: biological_process def: "The modification of peptidyl-cysteine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018199 name: peptidyl-glutamine modification namespace: biological_process def: "The modification of peptidyl-glutamine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018200 name: peptidyl-glutamic acid modification namespace: biological_process def: "The modification of peptidyl-glutamic acid." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018201 name: peptidyl-glycine modification namespace: biological_process def: "The modification of peptidyl-glycine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018202 name: peptidyl-histidine modification namespace: biological_process def: "The modification of peptidyl-histidine." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018203 name: peptidyl-isoleucine modification namespace: biological_process def: "The modification of peptidyl-isoleucine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018204 name: peptidyl-leucine modification namespace: biological_process def: "The modification of peptidyl-leucine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018205 name: peptidyl-lysine modification namespace: biological_process def: "The modification of peptidyl-lysine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018206 name: peptidyl-methionine modification namespace: biological_process def: "The modification of peptidyl-methionine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018207 name: peptidyl-phenylalanine modification namespace: biological_process def: "The modification of peptidyl-phenylalanine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018208 name: peptidyl-proline modification namespace: biological_process def: "The modification of peptidyl-proline." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018209 name: peptidyl-serine modification namespace: biological_process def: "The modification of peptidyl-serine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018210 name: peptidyl-threonine modification namespace: biological_process def: "The modification of peptidyl-threonine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018211 name: peptidyl-tryptophan modification namespace: biological_process def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018212 name: peptidyl-tyrosine modification namespace: biological_process def: "The modification of peptidyl-tyrosine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018213 name: peptidyl-valine modification namespace: biological_process def: "The modification of peptidyl-valine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018214 name: protein carboxylation namespace: biological_process def: "The addition of a carboxy group to a protein amino acid." [GOC:ai] synonym: "protein amino acid carboxylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018215 name: protein phosphopantetheinylation namespace: biological_process def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018216 name: peptidyl-arginine methylation namespace: biological_process alt_id: GO:0018017 def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018217 name: peptidyl-aspartic acid phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018218 name: peptidyl-cysteine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034] xref: RESID:AA0034 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018219 name: peptidyl-cysteine S-acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056] xref: RESID:AA0056 is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018220 name: peptidyl-threonine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079] comment: Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0079 is_a: GO:0018210 ! peptidyl-threonine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018221 name: peptidyl-serine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080] comment: Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom. synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0080 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018222 name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101] synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0101 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018226 name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102] synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0102 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018227 name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0103 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018228 name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104] synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0104 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018344 ! protein geranylgeranylation [Term] id: GO:0018229 name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105] synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0105 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018351 ! peptidyl-cysteine esterification [Term] id: GO:0018230 name: peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106] comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom. synonym: "peptidyl-cysteine S-palmitoylation" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0106 is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018231 name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107] synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0107 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018232 name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine namespace: biological_process def: "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108] xref: RESID:AA0108 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018233 name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109] xref: RESID:AA0109 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018234 name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine namespace: biological_process def: "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113] xref: RESID:AA0113 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018235 name: peptidyl-lysine carboxylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114] xref: RESID:AA0114 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0018237 name: urease activator activity namespace: molecular_function def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137] synonym: "urease activase activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0018238 name: peptidyl-lysine carboxyethylation namespace: biological_process alt_id: GO:0018239 def: "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115] synonym: "protein amino acid carboxyethylation" EXACT [] xref: RESID:AA0115 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018240 name: protein S-linked glycosylation via cysteine namespace: biological_process def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152] synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf] xref: RESID:AA0152 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018280 ! protein S-linked glycosylation [Term] id: GO:0018241 name: protein O-linked glycosylation via hydroxylysine namespace: biological_process def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153] synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf] xref: RESID:AA0153 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018242 name: protein O-linked glycosylation via serine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154] synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf] xref: RESID:AA0154 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018243 name: protein O-linked glycosylation via threonine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155] synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf] xref: RESID:AA0155 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018244 name: protein N-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156] synonym: "protein amino acid N-linked glycosylation via tryptophan" EXACT [GOC:bf] xref: RESID:AA0156 is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018245 name: protein O-linked glycosylation via tyrosine namespace: biological_process def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157] synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf] xref: RESID:AA0157 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018246 name: protein-coenzyme A linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018247 name: protein-phosphoribosyl dephospho-coenzyme A linkage namespace: biological_process def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167] xref: RESID:AA0167 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018246 ! protein-coenzyme A linkage [Term] id: GO:0018248 name: enzyme active site formation via peptidyl cysteine sulfation namespace: biological_process def: "The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT [] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098824 ! peptidyl-cysteine sulfation [Term] id: GO:0018249 name: protein dehydration namespace: biological_process def: "The removal of a water group from a protein amino acid." [GOC:ai] synonym: "protein amino acid dehydration" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018250 name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine namespace: biological_process def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181] synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT [] xref: RESID:AA0181 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0018251 name: peptidyl-tyrosine dehydrogenation namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183] comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. xref: RESID:AA0183 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration [Term] id: GO:0018252 name: peptide cross-linking via L-seryl-5-imidazolinone glycine namespace: biological_process def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018253 name: peptide cross-linking via 5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188] synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 xref: RESID:AA0187 xref: RESID:AA0188 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018254 name: peptidyl-tyrosine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203] synonym: "peptidyl-tyrosine adenylation" EXACT [] xref: RESID:AA0203 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018255 name: peptide cross-linking via S-glycyl-L-cysteine namespace: biological_process def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206] xref: RESID:AA0206 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018256 name: protein formylation namespace: biological_process def: "The addition of a formyl group to a protein amino acid." [GOC:ai] synonym: "protein amino acid formylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0018257 name: peptidyl-lysine formylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211] xref: RESID:AA0211 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018256 ! protein formylation [Term] id: GO:0018258 name: protein O-linked glycosylation via hydroxyproline namespace: biological_process def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212] synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf] xref: RESID:AA0212 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018259 name: RNA-protein covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213] xref: RESID:AA0213 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018260 name: protein guanylylation namespace: biological_process def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai] synonym: "protein amino acid guanylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018261 name: peptidyl-lysine guanylylation namespace: biological_process def: "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228] xref: RESID:AA0228 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018260 ! protein guanylylation [Term] id: GO:0018262 name: isopeptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg] is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018263 name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216] xref: RESID:AA0216 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018264 name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126] xref: RESID:AA0126 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018265 name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158] synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0158 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018266 name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159] synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0159 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018267 name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160] synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0160 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018268 name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161] synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0161 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018269 name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162] synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0162 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018270 name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163] synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0163 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018271 name: biotin-protein ligase activity namespace: molecular_function alt_id: GO:0000106 def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] synonym: "biotin-apoprotein ligase activity" EXACT [] xref: EC:6.3.4 xref: MetaCyc:BIOTINLIG-RXN xref: Reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)" xref: Reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2" xref: Reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+" xref: Reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+" xref: Reactome:R-HSA-3323184 "Defective HLCS does not biotinylate ACACA:Mn2+" xref: Reactome:R-HSA-4167511 "HLCS biotinylates ACACB" xref: Reactome:R-HSA-9035987 "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2" xref: Reactome:R-HSA-9035988 "Defective HLCS does not biotinylate PC:Mn2+" xref: Reactome:R-HSA-9035990 "Defective HLCS does not biotinylate 6x(PCCA:PCCB)" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0018272 name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119] xref: RESID:AA0119 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage [Term] id: GO:0018273 name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120] xref: RESID:AA0120 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018274 name: peptide cross-linking via L-lysinoalanine namespace: biological_process def: "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123] xref: RESID:AA0123 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018275 name: N-terminal peptidyl-cysteine acetylation namespace: biological_process alt_id: GO:0017191 def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043] synonym: "peptidyl-cysteine N-acetylation" EXACT [] xref: RESID:AA0043 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018276 name: isopeptide cross-linking via N6-glycyl-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125] comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. xref: RESID:AA0125 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0018277 name: protein deamination namespace: biological_process def: "The removal of an amino group from a protein amino acid." [GOC:ai] synonym: "protein amino acid deamination" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018278 name: N-terminal peptidyl-threonine deamination namespace: biological_process def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129] xref: RESID:AA0129 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018279 name: protein N-linked glycosylation via asparagine namespace: biological_process def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421] synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf] is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018280 name: protein S-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr] synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018281 name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine namespace: biological_process def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166] synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] xref: RESID:AA0166 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0042082 ! GSI anchor biosynthetic process [Term] id: GO:0018282 name: metal incorporation into metallo-sulfur cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg] synonym: "metal incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0018283 name: iron incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai] synonym: "iron incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018284 name: iron incorporation into protein via tetrakis-L-cysteinyl iron namespace: biological_process def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136] xref: RESID:AA0136 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018285 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide namespace: biological_process def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137] synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT [] xref: RESID:AA0137 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018286 name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138] comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form. synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide" EXACT [] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018287 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide namespace: biological_process def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT [] xref: RESID:AA0139 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018288 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140] synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0140 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018289 name: molybdenum incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai] synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018290 name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide namespace: biological_process def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141] synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT [] xref: RESID:AA0141 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster [Term] id: GO:0018291 name: molybdenum incorporation into iron-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai] synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster [Term] id: GO:0018292 name: molybdenum incorporation via L-cysteinyl molybdopterin namespace: biological_process def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142] xref: RESID:AA0142 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018293 name: protein-FAD linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018294 name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine namespace: biological_process def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143] xref: RESID:AA0143 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018295 name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144] xref: RESID:AA0144 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018296 name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine namespace: biological_process def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145] xref: RESID:AA0145 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018297 name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221] xref: RESID:AA0221 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018298 name: protein-chromophore linkage namespace: biological_process def: "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018299 name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide namespace: biological_process def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225] synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT [] xref: RESID:AA0225 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018300 name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226] comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist. synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide" EXACT [] synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018301 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon namespace: biological_process def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT [] xref: RESID:AA0268 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018302 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0284 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018303 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0285 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018304 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT [] xref: RESID:AA0286 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018305 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0288 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018306 name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289] synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0289 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018307 name: enzyme active site formation namespace: biological_process def: "The modification of part of an enzyme to form the active site." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018308 name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. synonym: "enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine" EXACT [] is_obsolete: true [Term] id: GO:0018309 name: protein-FMN linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018310 name: protein-FMN linkage via S-(6-FMN)-L-cysteine namespace: biological_process def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220] xref: RESID:AA0220 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0018311 name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT [] xref: RESID:AA0236 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018312 name: peptidyl-serine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237] xref: RESID:AA0237 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018313 name: peptide cross-linking via L-alanyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187] xref: RESID:AA0187 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine [Term] id: GO:0018314 name: obsolete protein-pyrroloquinoline-quinone linkage namespace: biological_process def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283] synonym: "protein-pyrroloquinoline-quinone linkage" EXACT [] is_obsolete: true replaced_by: GO:0006464 [Term] id: GO:0018315 name: molybdenum incorporation into molybdenum-molybdopterin complex namespace: biological_process alt_id: GO:0042041 def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai] synonym: "molybdenum incorporation into metallo-pterin complex" EXACT [] is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex relationship: has_part GO:0061599 ! molybdopterin molybdotransferase activity [Term] id: GO:0018316 name: peptide cross-linking via L-cystine namespace: biological_process def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025] xref: RESID:AA0025 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018317 name: protein C-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai] synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf] is_a: GO:0018103 ! protein C-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018320 name: enzyme active site formation via S-methyl-L-cysteine namespace: biological_process def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234] xref: RESID:AA0234 is_a: GO:0018125 ! peptidyl-cysteine methylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018321 name: protein glucuronylation namespace: biological_process def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr] synonym: "protein amino acid glucuronylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0018322 name: protein tyrosinylation namespace: biological_process def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai] synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018323 name: enzyme active site formation via L-cysteine sulfinic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262] synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT [] xref: RESID:AA0262 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018324 name: enzyme active site formation via L-cysteine sulfenic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205] synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT [] xref: RESID:AA0205 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018325 name: enzyme active site formation via S-phospho-L-cysteine namespace: biological_process def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034] xref: RESID:AA0034 is_a: GO:0018218 ! peptidyl-cysteine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018326 name: enzyme active site formation via S-acetyl-L-cysteine namespace: biological_process def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056] xref: RESID:AA0056 is_a: GO:0018219 ! peptidyl-cysteine S-acetylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018327 name: enzyme active site formation via 1'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035] xref: RESID:AA0035 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018328 name: enzyme active site formation via 3'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036] xref: RESID:AA0036 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018329 name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine namespace: biological_process def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227] xref: RESID:AA0227 is_a: GO:0018116 ! peptidyl-lysine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018330 name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine namespace: biological_process def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228] xref: RESID:AA0228 is_a: GO:0018261 ! peptidyl-lysine guanylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018331 name: enzyme active site formation via O-phospho-L-serine namespace: biological_process def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037] xref: RESID:AA0037 is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018332 name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine namespace: biological_process def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267] xref: RESID:AA0267 is_a: GO:0018178 ! peptidyl-threonine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018333 name: enzyme active site formation via O-phospho-L-threonine namespace: biological_process def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038] xref: RESID:AA0038 is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018334 name: enzyme active site formation via O4'-phospho-L-tyrosine namespace: biological_process def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039] xref: RESID:AA0039 is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018335 name: protein succinylation namespace: biological_process def: "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [GOC:bf] synonym: "protein amino acid succinylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0018336 name: peptidyl-tyrosine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai] is_a: GO:0018126 ! protein hydroxylation [Term] id: GO:0018337 name: obsolete enzyme active site formation via L-2',4',5'-topaquinone namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. synonym: "enzyme active site formation via L-2',4',5'-topaquinone" EXACT [] is_obsolete: true [Term] id: GO:0018338 name: obsolete protein amino acid cinnamylation namespace: biological_process def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "protein amino acid cinnamylation" EXACT [] is_obsolete: true consider: GO:0018097 [Term] id: GO:0018339 name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232] synonym: "peptidyl-aspartic acid methylthiolation" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0232 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018340 name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0264 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018341 name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT [] is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018342 name: protein prenylation namespace: biological_process alt_id: GO:0018346 def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732] synonym: "C-terminal protein prenylation" NARROW [] synonym: "protein amino acid prenylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0097354 ! prenylation [Term] id: GO:0018343 name: protein farnesylation namespace: biological_process alt_id: GO:0018347 def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl] synonym: "C-terminal protein farnesylation" NARROW [] synonym: "protein amino acid farnesylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018344 name: protein geranylgeranylation namespace: biological_process alt_id: GO:0018348 def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl] synonym: "C-terminal protein geranylgeranylation" NARROW [] synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018345 name: protein palmitoylation namespace: biological_process alt_id: GO:0018318 alt_id: GO:0018349 def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] synonym: "protein amino acid palmitoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018350 name: protein esterification namespace: biological_process def: "The addition of an ester group to a protein amino acid." [GOC:ai] synonym: "protein amino acid esterification" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018351 name: peptidyl-cysteine esterification namespace: biological_process def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah] is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018352 name: protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018353 name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine namespace: biological_process alt_id: GO:0018380 def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131] xref: RESID:AA0131 is_a: GO:0017009 ! protein-phycocyanobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018355 name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine namespace: biological_process def: "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167] is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage [Term] id: GO:0018356 name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine namespace: biological_process alt_id: GO:0018382 def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258] xref: RESID:AA0258 is_a: GO:0017008 ! protein-phycobiliviolin linkage [Term] id: GO:0018357 name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine namespace: biological_process alt_id: GO:0018383 def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260] xref: RESID:AA0260 is_a: GO:0017010 ! protein-phycourobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018358 name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine namespace: biological_process alt_id: GO:0018381 def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133] xref: RESID:AA0133 is_a: GO:0017012 ! protein-phytochromobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018359 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine namespace: biological_process alt_id: GO:0018385 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266] synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT [] xref: RESID:AA0266 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018360 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine namespace: biological_process alt_id: GO:0018384 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271] synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT [] xref: RESID:AA0271 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018361 name: peptidyl-glutamine 2-methylation namespace: biological_process def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273] xref: RESID:AA0273 is_a: GO:0018364 ! peptidyl-glutamine methylation [Term] id: GO:0018362 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester namespace: biological_process alt_id: GO:0019924 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279] synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT [] xref: RESID:AA0279 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018363 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium namespace: biological_process alt_id: GO:0019925 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280] synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT [] synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT [] xref: RESID:AA0280 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018364 name: peptidyl-glutamine methylation namespace: biological_process def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation [Term] id: GO:0018365 name: protein-serine epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] xref: EC:5.1.1.16 xref: MetaCyc:5.1.1.16-RXN is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0018366 name: chiral amino acid racemization namespace: biological_process def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0018367 name: obsolete free L-amino acid racemization namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is not clear that this process occurs. synonym: "free L-amino acid racemization" EXACT [] is_obsolete: true consider: GO:0006520 [Term] id: GO:0018376 name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine namespace: biological_process def: "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. xref: RESID:AA0026 is_a: GO:0042265 ! peptidyl-asparagine hydroxylation [Term] id: GO:0018377 name: protein myristoylation namespace: biological_process alt_id: GO:0018319 def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai] synonym: "protein amino acid myristoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018378 name: cytochrome c-heme linkage via heme-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135] synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT [] xref: RESID:AA0135 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018379 name: cytochrome c-heme linkage via heme-bis-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134] synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT [] xref: RESID:AA0134 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018386 name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274] xref: RESID:AA0274 is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018387 name: N-terminal peptidyl-amino acid deamination to pyruvic acid namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] xref: RESID:AA0127 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018388 name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275] xref: RESID:AA0275 is_a: GO:0018213 ! peptidyl-valine modification is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018389 name: N-terminal peptidyl-valine deamination namespace: biological_process def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018390 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018442 ! peptidyl-glutamic acid esterification [Term] id: GO:0018391 name: C-terminal peptidyl-glutamic acid tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah] is_a: GO:0018166 ! C-terminal protein-tyrosinylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018392 name: glycoprotein 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24444] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] xref: EC:2.4.1.214 xref: KEGG_REACTION:R06015 xref: MetaCyc:2.4.1.214-RXN xref: RHEA:24444 is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0018393 name: internal peptidyl-lysine acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] is_a: GO:0006475 ! internal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018394 name: peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of peptidyl-lysine." [GOC:mah] is_a: GO:0006473 ! protein acetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018395 name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028] xref: RESID:AA0028 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018396 name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235] xref: RESID:AA0235 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018397 name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174] xref: RESID:AA0174 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018398 name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175] xref: RESID:AA0175 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018399 name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176] xref: RESID:AA0176 is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018400 name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029] comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. xref: RESID:AA0029 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018401 name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030] comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. xref: RESID:AA0030 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018402 name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208] synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0208 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0018403 name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209] synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0209 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018404 name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210] synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0210 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018405 name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine namespace: biological_process def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247] synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT [] xref: RESID:AA0247 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018406 name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan namespace: biological_process alt_id: GO:0032004 def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217] synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf] synonym: "protein amino acid C-linked mannosylation" EXACT [] xref: RESID:AA0217 is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan is_a: GO:0035268 ! protein mannosylation [Term] id: GO:0018407 name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177] synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD [] xref: RESID:AA0177 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018408 name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178] xref: RESID:AA0178 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018410 name: C-terminal protein amino acid modification namespace: biological_process def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah] synonym: "peptide or protein carboxyl-terminal blocking" RELATED [] synonym: "peptide/protein carboxyl-terminal blocking" RELATED [] is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0018411 name: protein glucuronidation namespace: biological_process def: "The modification of a protein by amino acid glucuronidation." [GOC:ai] synonym: "protein amino acid glucuronidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018412 name: protein O-glucuronidation namespace: biological_process def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah] synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf] is_a: GO:0018411 ! protein glucuronidation [Term] id: GO:0018413 name: peptidyl-serine O-glucuronidation namespace: biological_process def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291] xref: RESID:AA0291 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018412 ! protein O-glucuronidation [Term] id: GO:0018414 name: nickel incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai] synonym: "nickel incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018415 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018416 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018417 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0293 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018418 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018419 name: protein catenane formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0018420 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine namespace: biological_process def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018421 name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018422 name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018423 name: protein C-terminal leucine carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774] synonym: "protein phosphatase methyltransferase activity" NARROW [] synonym: "protein-leucine O-methyltransferase activity" EXACT [] xref: Reactome:R-HSA-8856945 "PP2A methylation by LCMT1" is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018424 name: peptidyl-glutamic acid poly-ADP-ribosylation namespace: biological_process def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295] xref: RESID:AA0295 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018425 name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0296 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0018426 name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0297 is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine [Term] id: GO:0018427 name: copper incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai] synonym: "copper incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018428 name: copper incorporation into copper-sulfur cluster namespace: biological_process def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai] synonym: "copper incorporation into copper-sulphur cluster" EXACT [] is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster [Term] id: GO:0018429 name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide namespace: biological_process def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298] synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT [] xref: RESID:AA0298 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster [Term] id: GO:0018439 name: peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine namespace: biological_process alt_id: GO:0018440 def: "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299] synonym: "peptidyl-leucine esterification" EXACT [] xref: RESID:AA0299 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018203 ! peptidyl-isoleucine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018441 name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide namespace: biological_process def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300] synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT [] xref: RESID:AA0300 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide [Term] id: GO:0018442 name: peptidyl-glutamic acid esterification namespace: biological_process def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah] is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018443 name: enzyme active site formation via L-aspartic 4-phosphoric anhydride namespace: biological_process def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033] xref: RESID:AA0033 is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018444 name: translation release factor complex namespace: cellular_component def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] synonym: "eukaryotic peptide chain release factor" EXACT [] synonym: "peptide chain release factor" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0018445 name: prothoracicotrophic hormone activity namespace: molecular_function def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0018446 name: pinocarveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0717] xref: UM-BBD_reactionID:r0717 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018447 name: chloral hydrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] xref: UM-BBD_enzymeID:e0229 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018448 name: hydroxymethylmethylsilanediol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638] xref: UM-BBD_reactionID:r0638 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018449 name: 1-phenylethanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_reactionID:r0032] xref: UM-BBD_reactionID:r0032 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018450 name: myrtenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710] xref: UM-BBD_reactionID:r0710 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018451 name: epoxide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595] xref: UM-BBD_reactionID:r0595 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018452 name: 5-exo-hydroxycamphor dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427] xref: EC:1.1.1.327 xref: MetaCyc:R542-RXN xref: UM-BBD_reactionID:r0427 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018453 name: 2-hydroxytetrahydrofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018] xref: UM-BBD_reactionID:r0018 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018454 name: acetoacetyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36] xref: EC:1.1.1.36 xref: MetaCyc:RXN-7698 xref: RHEA:22256 xref: UM-BBD_reactionID:r0202 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018455 name: alcohol dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71] synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71] xref: EC:1.1.1.71 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN xref: RHEA:10736 xref: UM-BBD_reactionID:r0172 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018456 name: aryl-alcohol dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90] synonym: "benzyl alcohol dehydrogenase activity" NARROW [] synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] xref: EC:1.1.1.90 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0019 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018457 name: perillyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10664] synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144] synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144] xref: EC:1.1.1.144 xref: KEGG_REACTION:R03945 xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:10664 xref: UM-BBD_reactionID:r0729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018458 name: isopiperitenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20860] synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223] xref: EC:1.1.1.223 xref: KEGG_REACTION:R03261 xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN xref: RHEA:20860 xref: UM-BBD_reactionID:r0740 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018459 name: carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13629] synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243] synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243] xref: EC:1.1.1.243 xref: KEGG_REACTION:R03114 xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN xref: RHEA:13629 xref: UM-BBD_reactionID:r0714 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018460 name: cyclohexanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245] xref: EC:1.1.1.245 xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN xref: RHEA:10044 xref: UM-BBD_reactionID:r0165 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018461 name: fluoren-9-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] synonym: "9-fluorenol dehydrogenase activity" EXACT [] synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256] xref: EC:1.1.1.256 xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0408 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018462 name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24412] synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257] synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] xref: EC:1.1.1.257 xref: KEGG_REACTION:R05271 xref: MetaCyc:1.1.1.257-RXN xref: RHEA:24412 xref: UM-BBD_reactionID:r0291 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018463 name: 6-hydroxyhexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14225] synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258] xref: EC:1.1.1.258 xref: KEGG_REACTION:R05283 xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN xref: RHEA:14225 xref: UM-BBD_reactionID:r0174 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018464 name: 3-hydroxypimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11168] synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259] xref: EC:1.1.1.259 xref: KEGG_REACTION:R05305 xref: MetaCyc:1.1.1.259-RXN xref: RHEA:11168 xref: UM-BBD_reactionID:r0196 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018465 name: vanillyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10036] synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38] synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38] xref: EC:1.1.3.38 xref: KEGG_REACTION:R02877 xref: MetaCyc:1.1.3.38-RXN xref: RHEA:10036 xref: UM-BBD_reactionID:r0651 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0018466 name: limonene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735] xref: EC:1.1.99 xref: UM-BBD_reactionID:r0735 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018467 name: formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16425] synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46] synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.46 xref: KEGG_REACTION:R00604 xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:16425 xref: UM-BBD_reactionID:r0240 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0018468 name: alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8] synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "MDH" RELATED [EC:1.1.99.8] synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8] synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8] xref: EC:1.1.99.8 xref: UM-BBD_enzymeID:e0004 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018469 name: myrtenal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711] xref: UM-BBD_reactionID:r0711 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018470 name: 4-hydroxybutaraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014] xref: UM-BBD_reactionID:r0014 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018471 name: 4-chlorobenzaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0447 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018472 name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485] xref: UM-BBD_reactionID:r0485 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018473 name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744] xref: UM-BBD_reactionID:r0744 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018474 name: 2-carboxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0490 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0018475 name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745] xref: UM-BBD_reactionID:r0745 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018477 name: benzaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7] synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7] xref: EC:1.2.1.7 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21660 xref: UM-BBD_enzymeID:e0079 is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity [Term] id: GO:0018478 name: malonate-semialdehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18] synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] xref: EC:1.2.1.18 xref: MetaCyc:1.2.1.18-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018479 name: benzaldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28] synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28] xref: EC:1.2.1.28 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN xref: RHEA:11840 xref: UM-BBD_reactionID:r0269 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0018480 name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60] synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60] xref: EC:1.2.1.60 xref: MetaCyc:CHMS-DEHYDROGENASE-RXN xref: RHEA:15681 xref: UM-BBD_reactionID:r0365 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018481 name: 4-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22420] synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61] xref: EC:1.2.1.61 xref: KEGG_REACTION:R05236 xref: MetaCyc:1.2.1.61-RXN xref: RHEA:22420 xref: UM-BBD_reactionID:r0229 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018482 name: 4-formylbenzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18833] synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62] synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.62 xref: KEGG_REACTION:R05272 xref: MetaCyc:1.2.1.62-RXN xref: RHEA:18833 xref: UM-BBD_reactionID:r0292 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018483 name: 6-oxohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63] xref: EC:1.2.1.63 xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN xref: RHEA:13397 xref: UM-BBD_reactionID:r0175 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018484 name: 4-hydroxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64] synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64] xref: EC:1.2.1.64 xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN xref: RHEA:20305 xref: UM-BBD_reactionID:r0273 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0018485 name: salicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65] xref: EC:1.2.1.65 xref: MetaCyc:1.2.1.65-RXN xref: RHEA:18537 xref: UM-BBD_enzymeID:e0256 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0018486 name: 2-butanone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169] xref: UM-BBD_reactionID:r0169 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018487 name: vanillate O-demethylase (anaerobic) activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758] xref: UM-BBD_reactionID:r0758 is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018488 name: aryl-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9] synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] xref: EC:1.2.3.9 xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN xref: UM-BBD_reactionID:r0145 is_a: GO:0004031 ! aldehyde oxidase activity [Term] id: GO:0018489 name: vanillate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13021] comment: Note that this was EC:1.2.3.12. synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82] synonym: "vanillate demethylase (aerobic) activity" EXACT [] synonym: "vanillate demethylase activity" EXACT [] synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82] xref: EC:1.14.13.82 xref: KEGG_REACTION:R05274 xref: MetaCyc:RXN-10891 xref: MetaCyc:RXN-2 xref: RHEA:13021 xref: UM-BBD_reactionID:r0146 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018490 name: 4-hydroxyphenylpyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17197] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] xref: EC:1.2.3.13 xref: KEGG_REACTION:R00042 xref: MetaCyc:1.2.3.13-RXN xref: RHEA:17197 xref: UM-BBD_reactionID:r0299 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018491 name: 2-oxobutyrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [GOC:curators] synonym: "2-ketobutyrate synthase activity" EXACT [] synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [] synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [] synonym: "alpha-ketobutyrate synthase activity" EXACT [] synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [] xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN xref: UM-BBD_reactionID:r0358 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018492 name: carbon-monoxide dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.7.4] synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.7.4] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.7.4] xref: EC:1.2.7.4 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN xref: RHEA:21040 xref: UM-BBD_enzymeID:e0415 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018493 name: formylmethanofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.7.12, RHEA:19841] synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.7.12] synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.7.12] xref: EC:1.2.7.12 xref: KEGG_REACTION:R03015 xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN xref: RHEA:19841 xref: UM-BBD_reactionID:r0345 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018494 name: carvone reductase activity namespace: molecular_function def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_reactionID:r0732] xref: EC:1.3.99.25 xref: MetaCyc:RXN-9403 xref: MetaCyc:RXN-9419 xref: UM-BBD_reactionID:r0732 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018495 name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192] xref: UM-BBD_reactionID:r0192 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018496 name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205] xref: UM-BBD_reactionID:r0205 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018497 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514] synonym: "DDMS dehydrogenase activity" EXACT [] xref: UM-BBD_reactionID:r0514 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018498 name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN xref: UM-BBD_enzymeID:e0308 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018499 name: cis-2,3-dihydrodiol DDT dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451] xref: UM-BBD_reactionID:r0451 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018500 name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575] xref: UM-BBD_reactionID:r0575 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018501 name: cis-chlorobenzene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411] xref: UM-BBD_enzymeID:e0411 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018502 name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553] xref: MetaCyc:LINC-RXN xref: UM-BBD_reactionID:r0553 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018503 name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574] xref: UM-BBD_reactionID:r0574 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018504 name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] xref: EC:1.3.1.19 xref: MetaCyc:1.3.1.19-RXN xref: UM-BBD_enzymeID:e0060 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018505 name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29] synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] xref: EC:1.3.1.29 xref: MetaCyc:1.3.1.29-RXN xref: RHEA:11832 xref: UM-BBD_enzymeID:e0122 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018506 name: maleylacetate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32] synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32] xref: EC:1.3.1.32 xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0063 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018507 name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16253] synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49] synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] xref: EC:1.3.1.49 xref: KEGG_REACTION:R04151 xref: MetaCyc:1.3.1.49-RXN xref: RHEA:16253 xref: UM-BBD_reactionID:r0488 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018508 name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0219 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018509 name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56] synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56] xref: EC:1.3.1.56 xref: MetaCyc:1.3.1.56-RXN xref: RHEA:17033 xref: UM-BBD_enzymeID:e0134 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018510 name: phloroglucinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10080] synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57] xref: EC:1.3.1.57 xref: KEGG_REACTION:R05308 xref: MetaCyc:R5-RXN xref: RHEA:10080 xref: UM-BBD_reactionID:r0007 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018511 name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23772] synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58] xref: EC:1.3.1.58 xref: KEGG_REACTION:R05240 xref: MetaCyc:RXN-665 xref: RHEA:23772 xref: UM-BBD_reactionID:r0396 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018512 name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59] comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists. synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT [] synonym: "1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity" EXACT [] xref: UM-BBD_reactionID:r0216 is_obsolete: true [Term] id: GO:0018513 name: dibenzothiophene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24188] synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60] xref: EC:1.3.1.60 xref: KEGG_REACTION:R05310 xref: MetaCyc:1.3.1.60-RXN xref: RHEA:24188 xref: UM-BBD_reactionID:r0161 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018515 name: pimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19665] synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62] xref: EC:1.3.1.62 xref: KEGG_REACTION:R05311 xref: MetaCyc:1.3.1.62-RXN xref: RHEA:19665 xref: UM-BBD_reactionID:r0194 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018516 name: 2,4-dichlorobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23076] synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.21.1.2] xref: EC:1.21.1.2 xref: KEGG_REACTION:R05276 xref: MetaCyc:1.3.1.63-RXN xref: RHEA:23076 xref: UM-BBD_reactionID:r0138 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018517 name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13837] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64] xref: EC:1.3.1.64 xref: KEGG_REACTION:R05275 xref: MetaCyc:1.3.1.64-RXN xref: RHEA:13837 xref: UM-BBD_reactionID:r0142 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018518 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24556] synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65] xref: EC:1.3.1.65 xref: KEGG_REACTION:R05312 xref: MetaCyc:RXN-643 xref: RHEA:24556 xref: UM-BBD_reactionID:r0053 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018519 name: cis-dihydroethylcatechol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18101] synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66] synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] xref: EC:1.3.1.66 xref: KEGG_REACTION:R05313 xref: MetaCyc:1.3.1.66-RXN xref: RHEA:18101 xref: UM-BBD_reactionID:r0309 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018520 name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67] xref: EC:1.3.1.67 xref: MetaCyc:1.3.1.67-RXN xref: UM-BBD_reactionID:r0179 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018521 name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15657] synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68] xref: EC:1.3.1.68 xref: KEGG_REACTION:R05314 xref: MetaCyc:1.3.1.68-RXN xref: RHEA:15657 xref: UM-BBD_reactionID:r0224 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018522 name: benzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8] synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.7.8] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity" EXACT [KEGG_REACTION:R02451] xref: EC:1.3.7.8 xref: KEGG_REACTION:R02451 xref: MetaCyc:1.3.99.15-RXN xref: UM-BBD_reactionID:r0190 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0018523 name: quinoline 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] xref: EC:1.3.99.17 xref: MetaCyc:1.3.99.17-RXN xref: UM-BBD_reactionID:r0045 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018524 name: acetophenone carboxylase activity namespace: molecular_function alt_id: GO:0018797 def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033] xref: EC:6.4.1 xref: UM-BBD_reactionID:r0033 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018525 name: 4-hydroxybenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [KEGG_REACTION:R05316] synonym: "4-hydroxybenzoyl-coA reductase (dehydroxylating) activity" EXACT [EC:1.3.7.9] synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.7.9] xref: EC:1.3.7.9 xref: KEGG_REACTION:R05316 xref: MetaCyc:OHBENZCOARED-RXN xref: UM-BBD_reactionID:r0158 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0018526 name: 2-aminobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342] xref: UM-BBD_reactionID:r0342 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0018527 name: cyclohexylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12] synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12] xref: EC:1.4.3.12 xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN xref: RHEA:18433 xref: UM-BBD_reactionID:r0754 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0018528 name: iminodiacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589] xref: UM-BBD_reactionID:r0589 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018529 name: nitrilotriacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587] xref: EC:1.14.14.10 xref: UM-BBD_reactionID:r0587 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0018530 name: (R)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10012] synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6] synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6] xref: EC:1.5.3.6 xref: KEGG_REACTION:R07170 xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:10012 xref: UM-BBD_reactionID:r0477 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018531 name: (S)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11880] synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] xref: EC:1.5.3.5 xref: KEGG_REACTION:R03202 xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:11880 xref: UM-BBD_reactionID:r0478 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018532 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353] synonym: "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "coenzyme F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] synonym: "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0353 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018533 name: peptidyl-cysteine acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine." [GOC:mah] is_a: GO:0006473 ! protein acetylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018534 name: nitrilotriacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0588 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018535 name: nicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] xref: EC:1.5.99.4 xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN xref: RHEA:14769 xref: UM-BBD_enzymeID:e0337 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018537 name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.2, RHEA:21144] synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.98.2] synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.98.2] synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.98.2] synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.98.2] synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.98.2] synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.98.2] synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.98.2] synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.98.2] synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.98.2] synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.98.2] xref: EC:1.5.98.2 xref: KEGG_REACTION:R04464 xref: MetaCyc:METHELENE-THMPT-OXI-RXN xref: RHEA:21144 xref: UM-BBD_reactionID:r0354 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018538 name: epoxide carboxylase activity namespace: molecular_function def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0018541 name: p-benzoquinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23488] synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6] xref: EC:1.6.5.6 xref: KEGG_REACTION:R05244 xref: MetaCyc:1.6.5.6-RXN xref: RHEA:23488 xref: UM-BBD_enzymeID:e0422 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0018542 name: 2,3-dihydroxy DDT 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0452 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018543 name: 4-amino-2-nitroso-6-nitrotoluene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464] xref: UM-BBD_reactionID:r0464 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018544 name: 4-carboxy-4'-sulfoazobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543] synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] xref: UM-BBD_reactionID:r0543 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018545 name: NAD(P)H nitroreductase activity namespace: molecular_function def: "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346] xref: UM-BBD_enzymeID:e0346 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018546 name: nitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815] xref: MetaCyc:RXN-8815 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018547 name: nitroglycerin reductase activity namespace: molecular_function def: "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] synonym: "NG reductase activity" EXACT [] xref: UM-BBD_enzymeID:e0038 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0018548 name: pentaerythritol trinitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] xref: EC:1.6.99.1 xref: UM-BBD_reactionID:r0025 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0018549 name: methanethiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4] synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4] synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4] synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4] xref: EC:1.8.3.4 xref: MetaCyc:METHANETHIOL-OXIDASE-RXN xref: RHEA:11812 xref: UM-BBD_reactionID:r0209 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0018550 name: tetrachloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT [] xref: EC:1.8.99 xref: UM-BBD_reactionID:r0314 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018551 name: hydrogensulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3] synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] synonym: "dissimilatory sulfite reductase activity" EXACT [] synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "hydrogensulphite reductase activity" EXACT [] synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3] synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3] xref: EC:1.8.99.3 xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN xref: RHEA:13209 xref: UM-BBD_reactionID:r0627 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018553 name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] xref: UM-BBD_enzymeID:e0309 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018554 name: 1,2-dihydroxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] xref: EC:1.13.11.56 xref: RHEA:27310 xref: UM-BBD_enzymeID:e0255 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018555 name: phenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0455 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018556 name: 2,2',3-trihydroxybiphenyl dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] xref: EC:1.13.11 xref: UM-BBD_enzymeID:e0032 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018557 name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0422 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018558 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0049 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018559 name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442] synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0442 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018560 name: protocatechuate 3,4-dioxygenase type II activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0581 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018561 name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0457 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018562 name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0415 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018563 name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0310 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018564 name: carbazole 1,9a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456] synonym: "carbazole 1,9alpha-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0456 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018565 name: dihydroxydibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0162 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018566 name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324] synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0324 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018567 name: styrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0256 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018568 name: 3,4-dihydroxyphenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0501 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018569 name: hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0228 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018570 name: p-cumate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395] xref: EC:1.13.11 xref: MetaCyc:RXN-664 xref: UM-BBD_reactionID:r0395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018571 name: 2,3-dihydroxy-p-cumate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_reactionID:r0397] synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] xref: EC:1.13.11 xref: MetaCyc:RXN-666 xref: UM-BBD_reactionID:r0397 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018572 name: 3,5-dichlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0276 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018573 name: 2-aminophenol 1,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0305 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018574 name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] xref: EC:1.13.11 xref: UM-BBD_enzymeID:e0422 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018575 name: chlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0655 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018576 name: catechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1] synonym: "catechase activity" RELATED [EC:1.13.11.1] synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1] synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "CD I" RELATED [EC:1.13.11.1] synonym: "CD II" RELATED [EC:1.13.11.1] synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1] xref: EC:1.13.11.1 xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN xref: RHEA:23852 xref: UM-BBD_enzymeID:e0064 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018577 name: catechol 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2] synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2] synonym: "cato2ase activity" RELATED [EC:1.13.11.2] synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2] xref: EC:1.13.11.2 xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN xref: RHEA:17337 xref: UM-BBD_enzymeID:e0156 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018578 name: protocatechuate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3] xref: EC:1.13.11.3 xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN xref: RHEA:10084 xref: UM-BBD_reactionID:r0143 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018579 name: protocatechuate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8] xref: EC:1.13.11.8 xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN xref: RHEA:24044 xref: UM-BBD_reactionID:r0144 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018580 name: nitronate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770] comment: Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'. synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.11.32] synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16] xref: EC:1.13.12.16 xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN xref: RHEA:28770 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0018581 name: hydroxyquinol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37] synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37] xref: EC:1.13.11.37 xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN xref: RHEA:19441 xref: UM-BBD_reactionID:r0232 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018582 name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38] xref: EC:1.13.11.38 xref: MetaCyc:1.13.11.38-RXN xref: RHEA:14749 xref: UM-BBD_reactionID:r0486 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018583 name: biphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39] synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39] xref: EC:1.13.11.39 xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN xref: RHEA:14413 xref: UM-BBD_enzymeID:e0127 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018584 name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359] xref: EC:1.13.99 xref: UM-BBD_reactionID:r0359 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0018585 name: fluorene oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407] xref: UM-BBD_reactionID:r0407 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018586 name: mono-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647] synonym: "MBT dioxygenase activity" EXACT [] xref: UM-BBD_reactionID:r0647 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018587 name: obsolete limonene 8-monooxygenase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "limonene 8-monooxygenase activity" EXACT [] is_obsolete: true replaced_by: GO:0019113 [Term] id: GO:0018588 name: tri-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643] synonym: "TBT dioxygenase activity" EXACT [] xref: UM-BBD_reactionID:r0643 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018589 name: di-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645] synonym: "DBT dioxygenase activity" EXACT [] xref: UM-BBD_reactionID:r0645 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018590 name: methylsilanetriol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640] xref: UM-BBD_reactionID:r0640 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018591 name: methyl tertiary butyl ether 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] synonym: "MTBE 3-monooxygenase activity" EXACT [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018592 name: 4-nitrocatechol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231] xref: EC:1.14.13.166 xref: UM-BBD_reactionID:r0231 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018593 name: 4-chlorophenoxyacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281] xref: UM-BBD_reactionID:r0281 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018594 name: tert-butanol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018595 name: alpha-pinene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716] xref: EC:1.14.13.155 xref: RHEA:32891 xref: UM-BBD_reactionID:r0716 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018596 name: dimethylsilanediol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637] synonym: "DMSD hydroxylase activity" EXACT [] xref: UM-BBD_reactionID:r0637 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018597 name: ammonia monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810] xref: EC:1.14.99.39 xref: RHEA:27341 xref: UM-BBD_enzymeID:e0061 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018598 name: hydroxymethylsilanetriol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641] xref: UM-BBD_reactionID:r0641 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018599 name: 2-hydroxyisobutyrate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619] xref: UM-BBD_reactionID:r0619 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018600 name: alpha-pinene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709] xref: EC:1.14 xref: UM-BBD_reactionID:r0709 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018601 name: 4-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12568] synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29] xref: EC:1.14.13.29 xref: KEGG_REACTION:R03023 xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN xref: RHEA:12568 xref: UM-BBD_reactionID:r0230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018602 name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274] xref: EC:1.14.11 xref: MetaCyc:RXN-9863 xref: UM-BBD_reactionID:r0274 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0018603 name: nitrobenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0306 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018604 name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0566 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018606 name: benzenesulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295] synonym: "benzenesulphonate dioxygenase activity" EXACT [] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0295 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018607 name: 1-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0417 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018608 name: 1-indanone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0416 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018609 name: chlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] xref: EC:1.14.12 xref: UM-BBD_enzymeID:e0062 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018610 name: dibenzofuran 4,4a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] xref: EC:1.14.12 xref: MetaCyc:R606-RXN xref: UM-BBD_enzymeID:e0030 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018611 name: toluate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] xref: EC:1.14.12 xref: UM-BBD_enzymeID:e0190 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018612 name: dibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0160 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018613 name: 9-fluorenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0409 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018614 name: ethylbenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0247 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018615 name: 2-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0424 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018616 name: trihydroxytoluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_reactionID:r0093] xref: EC:1.14.12 xref: MetaCyc:R305-RXN xref: UM-BBD_reactionID:r0093 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018617 name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580] synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0580 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018618 name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] synonym: "AntA" RELATED [] synonym: "AntB" RELATED [] synonym: "AntC" RELATED [] synonym: "anthranilate 1,2-dioxygenase" RELATED [] synonym: "anthranilate dioxygenase activity" EXACT [] synonym: "anthranilate dioxygenase reductase" NARROW [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] xref: EC:1.14.12.1 xref: MetaCyc:1.14.12.1-RXN xref: UM-BBD_reactionID:r0577 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018619 name: benzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13813] synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3] synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3] xref: EC:1.14.12.3 xref: KEGG_REACTION:R03543 xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN xref: RHEA:13813 xref: UM-BBD_reactionID:r0079 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018620 name: phthalate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17489] synonym: "PDO activity" EXACT [EC:1.14.12.7] synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7] xref: EC:1.14.12.7 xref: KEGG_REACTION:R03630 xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN xref: RHEA:17489 xref: UM-BBD_reactionID:r0102 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018621 name: 4-sulfobenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13937] synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8] synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8] synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] xref: EC:1.14.12.8 xref: KEGG_REACTION:R01636 xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN xref: RHEA:13937 xref: UM-BBD_reactionID:r0293 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018622 name: 4-chlorophenylacetate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14689] synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9] xref: EC:1.14.12.9 xref: KEGG_REACTION:R03306 xref: MetaCyc:1.14.12.9-RXN xref: RHEA:14689 xref: UM-BBD_reactionID:r0308 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018623 name: benzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10] synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10] synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10] xref: EC:1.14.12.10 xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN xref: RHEA:12633 xref: UM-BBD_enzymeID:e0154 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018624 name: toluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16737] synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11] xref: EC:1.14.12.11 xref: KEGG_REACTION:R03559 xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN xref: RHEA:16737 xref: UM-BBD_enzymeID:e0155 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018625 name: naphthalene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12] xref: EC:1.14.12.12 xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN xref: RHEA:19173 xref: UM-BBD_enzymeID:e0002 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018626 name: 2-chlorobenzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13] synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.12.13 xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN xref: RHEA:21652 xref: UM-BBD_reactionID:r0632 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018627 name: 2-aminobenzenesulfonate 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0018605 def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23468] synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14] synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14] xref: EC:1.14.12.14 xref: KEGG_REACTION:R05156 xref: MetaCyc:2ASDOSALCAL-RXN xref: RHEA:23468 xref: UM-BBD_reactionID:r0218 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018628 name: terephthalate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10312] synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15] xref: EC:1.14.12.15 xref: KEGG_REACTION:R05148 xref: MetaCyc:1.14.12.15-RXN xref: RHEA:10312 xref: UM-BBD_reactionID:r0150 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018629 name: 2-hydroxyquinoline 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16] xref: EC:1.14.12.16 xref: MetaCyc:1.14.12.16-RXN xref: RHEA:10976 xref: UM-BBD_reactionID:r0052 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018630 name: 3,5-xylenol methylhydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081] xref: EC:1.14.13 xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN xref: UM-BBD_reactionID:r0081 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018631 name: phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0036 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018632 name: 4-nitrophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226] xref: EC:1.14.13 xref: MetaCyc:RXN-8739 xref: UM-BBD_reactionID:r0226 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018633 name: dimethyl sulfide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208] synonym: "dimethyl sulphide monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018634 name: alpha-pinene monooxygenase [NADH] activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0742 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018635 name: (R)-limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] synonym: "(+)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107] synonym: "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] synonym: "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] xref: EC:1.14.13.107 xref: KEGG_REACTION:R06398 "limonene,NADH:oxygen oxidoreductase" xref: KEGG_REACTION:R09393 "limonene,NADPH:oxygen oxidoreductase" xref: MetaCyc:RXN-9407 xref: RHEA:26093 xref: RHEA:26097 xref: UM-BBD_reactionID:r0733 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018636 name: phenanthrene 9,10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0495 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018637 name: 1-hydroxy-2-naphthoate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0491 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018638 name: toluene 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018639 name: xylene monooxygenase activity namespace: molecular_function def: "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0172 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018640 name: dibenzothiophene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] xref: EC:1.14.13 xref: MetaCyc:RXN-621 xref: UM-BBD_enzymeID:e0214 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018641 name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0048 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018642 name: chlorophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018643 name: carbon disulfide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599] synonym: "carbon disulphide oxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0599 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018644 name: toluene 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] xref: EC:1.14.13 xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0222 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018645 name: alkene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69] synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69] xref: EC:1.14.13.69 xref: MetaCyc:1.14.13.69-RXN xref: RHEA:11792 xref: UM-BBD_enzymeID:e0039 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018646 name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0736 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018647 name: phenanthrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0333 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018648 name: methanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111] synonym: "mesylate monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111] synonym: "methanesulfonic acid monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah] synonym: "MSA monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "MSAMO activity" EXACT [EC:1.14.13.111] xref: EC:1.14.13.111 xref: MetaCyc:RXN-9770 xref: RHEA:26077 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018649 name: tetrahydrofuran hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0017 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018650 name: styrene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018651 name: toluene-4-sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296] synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0296 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018652 name: toluene-sulfonate methyl-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_reactionID:r0290] synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: MetaCyc:TSMOS-RXN xref: UM-BBD_reactionID:r0290 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018653 name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0046 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018654 name: 2-hydroxy-phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018655 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0430 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018656 name: phenanthrene 3,4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0508 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018657 name: toluene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] xref: EC:1.14.13 xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0224 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018658 name: salicylate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase activity" EXACT [] synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1] synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1] xref: EC:1.14.13.1 xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN xref: RHEA:11004 xref: UM-BBD_enzymeID:e0149 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018659 name: 4-hydroxybenzoate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2] synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] xref: EC:1.14.13.2 xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN xref: RHEA:19477 xref: UM-BBD_reactionID:r0109 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018660 name: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [KEGG_REACTION:R02698] synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.13.3] synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" BROAD [] synonym: "4-hydroxyphenylacetate 3-monooxygenase activity" BROAD [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.13.3] xref: EC:1.14.13 xref: KEGG_REACTION:R02698 xref: RHEA:16681 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018661 name: orcinol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19601] synonym: "orcinol hydroxylase activity" EXACT [] synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6] xref: EC:1.14.13.6 xref: KEGG_REACTION:R02830 xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN xref: RHEA:19601 xref: UM-BBD_reactionID:r0092 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018662 name: phenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7] xref: EC:1.14.13.7 xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN xref: RHEA:17061 xref: UM-BBD_enzymeID:e0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018663 name: 2,6-dihydroxypyridine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16917] synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10] xref: EC:1.14.13.10 xref: KEGG_REACTION:R04130 xref: MetaCyc:1.14.13.10-RXN xref: RHEA:16917 xref: UM-BBD_reactionID:r0479 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018664 name: benzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.14.92, RHEA:18033] synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.14.92] synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.14.92] synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.14.92] synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.14.92] synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.14.92] synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.14.92] synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.14.92] xref: EC:1.14.14.92 xref: KEGG_REACTION:R01295 xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:18033 xref: UM-BBD_reactionID:r0623 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018665 name: 4-hydroxyphenylacetate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18] xref: EC:1.14.13.18 xref: MetaCyc:1.14.13.18-RXN xref: UM-BBD_reactionID:r0300 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018666 name: 2,4-dichlorophenol 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20] synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20] xref: EC:1.14.13.20 xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN xref: RHEA:20920 xref: UM-BBD_enzymeID:e0152 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018667 name: cyclohexanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22] xref: EC:1.14.13.22 xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN xref: RHEA:24068 xref: UM-BBD_reactionID:r0166 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018668 name: 3-hydroxybenzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11480] synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23] xref: EC:1.14.13.23 xref: KEGG_REACTION:R01628 xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:11480 xref: UM-BBD_reactionID:r0153 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018669 name: 3-hydroxybenzoate 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22692] synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24] synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24] synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24] xref: EC:1.14.13.24 xref: KEGG_REACTION:R02589 xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN xref: RHEA:22692 xref: UM-BBD_reactionID:r0402 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018670 name: 4-aminobenzoate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate hydroxylase activity" EXACT [] synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27] xref: EC:1.14.13.27 xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0597 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018671 name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33] synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] xref: EC:1.14.13.33 xref: MetaCyc:1.14.13.33-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018672 name: anthranilate 3-monooxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21236] synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35] synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35] synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35] xref: EC:1.14.13.35 xref: KEGG_REACTION:R00980 xref: MetaCyc:1.14.13.35-RXN xref: RHEA:21236 xref: UM-BBD_reactionID:r0578 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018673 name: anthraniloyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40] synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40] xref: EC:1.14.13.40 xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0568 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018674 name: (S)-limonene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.14.99, RHEA:15129] synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.14.99] synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.14.99] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.14.99] synonym: "limonene 3-hydroxylase activity" EXACT [] xref: EC:1.14.14.99 xref: KEGG_REACTION:R02469 xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN xref: RHEA:15129 xref: UM-BBD_reactionID:r0739 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018675 name: (S)-limonene 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.14.51] synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.14.51] synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.14.51] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.14.51] synonym: "limonene 6-hydroxylase activity" EXACT [] xref: EC:1.14.14.51 xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN xref: RHEA:17945 xref: UM-BBD_reactionID:r0713 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018676 name: (S)-limonene 7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.14.52, RHEA:23432] synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] xref: EC:1.14.14.52 xref: KEGG_REACTION:R02470 xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN xref: RHEA:23432 xref: UM-BBD_reactionID:r0728 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018677 name: pentachlorophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50] synonym: "PCB4MO activity" EXACT [EC:1.14.13.50] synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50] synonym: "PcpB" RELATED [EC:1.14.13.50] synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol hydroxylase activity" EXACT [] synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] xref: EC:1.14.13.50 xref: MetaCyc:PCP4MONO-RXN xref: UM-BBD_enzymeID:e0148 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018678 name: 4-hydroxybenzoate 1-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64] xref: EC:1.14.13.64 xref: MetaCyc:1.14.13.64-RXN xref: UM-BBD_reactionID:r0752 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018679 name: dibenzothiophene-5,5-dioxide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235] xref: EC:1.14.14 xref: MetaCyc:RXN-623 xref: UM-BBD_reactionID:r0235 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018680 name: deethylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128] xref: EC:1.14.15 xref: UM-BBD_reactionID:r0128 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018681 name: deisopropylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG_REACTION:R05567] xref: EC:1.14.15 xref: KEGG_REACTION:R05567 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018682 name: atrazine N-dealkylase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127] synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090] xref: EC:1.14.15 xref: MetaCyc:R461-RXN xref: UM-BBD_reactionID:r0127 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018683 name: camphor 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1] synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1] synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1] synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] xref: EC:1.14.15.1 xref: MetaCyc:R541-RXN xref: UM-BBD_enzymeID:e0300 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018684 name: camphor 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2] synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2] synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2] synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2] synonym: "ketolactonase I" RELATED [EC:1.14.15.2] synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2] xref: EC:1.14.15.2 xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0302 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018685 name: alkane 1-monooxygenase activity namespace: molecular_function alt_id: GO:0008393 def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane 1-hydroxylase activity" EXACT [] synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3] synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3] synonym: "fatty acid (omega-1)-hydroxylase activity" EXACT [] synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] xref: EC:1.14.15.3 xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0022 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018686 name: 6-hydroxy pseudo-oxynicotine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480] xref: EC:1.14.18 xref: UM-BBD_reactionID:r0480 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018687 name: biphenyl 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18] synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18] synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18] xref: EC:1.14.12.18 xref: MetaCyc:1.14.12.18-RXN xref: RHEA:18165 xref: UM-BBD_enzymeID:e0089 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018688 name: DDT 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450] xref: EC:1.14.99 xref: UM-BBD_reactionID:r0450 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018689 name: naphthalene disulfonate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.99 xref: UM-BBD_enzymeID:e0249 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018690 name: 4-methoxybenzoate monooxygenase (O-demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18613] synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15] xref: EC:1.14.99.15 xref: KEGG_REACTION:R01306 xref: MetaCyc:1.14.99.15-RXN xref: RHEA:18613 xref: UM-BBD_reactionID:r0154 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018693 name: ethylbenzene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17897] synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2] synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2] xref: EC:1.17.99.2 xref: KEGG_REACTION:R05745 xref: MetaCyc:RXN-1301 xref: RHEA:17897 xref: UM-BBD_reactionID:r0234 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018694 name: p-cymene methyl hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392] xref: EC:1.17.99 xref: MetaCyc:RXN-661 xref: UM-BBD_reactionID:r0392 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018695 name: 4-cresol dehydrogenase (hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.9.1] synonym: "4-cresol dehydrogenase activity" EXACT [] synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.9.1] synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.9.1] synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.9.1] xref: EC:1.17.9.1 xref: MetaCyc:1.17.99.1-RXN xref: RHEA:15141 xref: UM-BBD_reactionID:r0272 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018697 name: carbonyl sulfide nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600] synonym: "carbonyl sulphide nitrogenase activity" EXACT [] xref: EC:1.18.6.1 xref: UM-BBD_reactionID:r0600 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0018698 name: vinyl chloride reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene." [UM-BBD_reactionID:r0352] xref: EC:1.97.1 xref: MetaCyc:VCREDCHLOR-RXN xref: UM-BBD_reactionID:r0352 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018699 name: 1,1,1-trichloroethane reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007] xref: EC:1.97.1 xref: UM-BBD_reactionID:r1007 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018700 name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0719 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018701 name: 2,5-dichlorohydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] xref: EC:1.97.1 xref: UM-BBD_enzymeID:e0366 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018702 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440] synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] synonym: "DDE dehalogenase activity" EXACT [] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0440 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018703 name: 2,4-dichlorophenoxyacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280] xref: UM-BBD_reactionID:r0280 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018704 name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity" EXACT [] is_obsolete: true [Term] id: GO:0018705 name: 1,2-dichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0272 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018706 name: pyrogallol hydroxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2] synonym: "pyrogallol hydroxyltransferase activity" EXACT [] synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] xref: EC:1.97.1.2 xref: MetaCyc:1.97.1.2-RXN xref: UM-BBD_reactionID:r0006 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018707 name: 1-phenanthrol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493] xref: UM-BBD_reactionID:r0493 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0018708 name: thiol S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "TMT" RELATED [EC:2.1.1.9] xref: EC:2.1.1.9 xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME" xref: UM-BBD_enzymeID:e0146 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018710 name: acetone carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18385] synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6] xref: EC:6.4.1.6 xref: KEGG_REACTION:R05735 xref: MetaCyc:6.4.1.6-RXN xref: RHEA:18385 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018711 name: benzoyl acetate-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243] xref: MetaCyc:RXN-1305 xref: UM-BBD_reactionID:r0243 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018712 name: 3-hydroxybutyryl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010] xref: MetaCyc:R7-RXN xref: UM-BBD_reactionID:r0010 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018713 name: 3-ketopimelyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197] xref: MetaCyc:RXN-8032 xref: UM-BBD_reactionID:r0197 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018715 name: 9-phenanthrol UDP-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567] xref: EC:2.4.1 xref: UM-BBD_reactionID:r0567 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0018716 name: 1-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525] xref: UM-BBD_reactionID:r0525 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018717 name: 9-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511] xref: UM-BBD_reactionID:r0511 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018718 name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569] xref: EC:2.4.1 xref: UM-BBD_reactionID:r0569 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0018719 name: 6-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449] xref: MetaCyc:R562-RXN xref: UM-BBD_reactionID:r0449 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0018720 name: phenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_reactionID:r0155] xref: MetaCyc:PHENOLPHOS-RXN xref: UM-BBD_reactionID:r0155 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0018721 name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559] synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0559 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018722 name: 1-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565] synonym: "1-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0565 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018723 name: 3-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561] synonym: "3-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0561 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018724 name: 4-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562] synonym: "4-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0562 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018725 name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558] synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0558 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018726 name: 9-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564] synonym: "9-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0564 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018727 name: 2-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563] synonym: "2-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0563 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018729 name: propionate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1] xref: EC:2.8.3.1 xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN xref: RHEA:23520 xref: UM-BBD_reactionID:r0087 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018730 name: glutaconate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12] xref: EC:2.8.3.12 xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN xref: RHEA:23208 xref: UM-BBD_reactionID:r0085 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018731 name: 1-oxa-2-oxocycloheptane lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167] xref: UM-BBD_reactionID:r0167 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018732 name: sulfolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583] synonym: "sulpholactone hydrolase activity" EXACT [] xref: EC:3.1.1.92 xref: UM-BBD_reactionID:r0583 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018733 name: 3,4-dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419] xref: EC:3.1.1.35 xref: UM-BBD_reactionID:r0419 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018734 name: butyrolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_reactionID:r0016] xref: UM-BBD_reactionID:r0016 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018736 name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206] xref: UM-BBD_reactionID:r0206 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018737 name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193] xref: UM-BBD_reactionID:r0193 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018738 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14961] subset: goslim_chembl xref: EC:3.1.2.12 xref: KEGG_REACTION:R00527 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: Reactome:R-HSA-5693724 "ESD dimer hydrolyses S-FGSH to GSH" xref: RHEA:14961 xref: UM-BBD_reactionID:r0241 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0018739 name: 4-hydroxybenzoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11948] synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23] synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.23 xref: KEGG_REACTION:R01301 xref: MetaCyc:3.1.2.23-RXN xref: RHEA:11948 xref: UM-BBD_reactionID:r0141 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0018740 name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12945] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] synonym: "DszB" RELATED [EC:3.13.1.3] synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3] synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3] synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3] xref: EC:3.13.1.3 xref: KEGG_REACTION:R07311 xref: MetaCyc:RXN-624 xref: RHEA:12945 xref: UM-BBD_enzymeID:e0216 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0018741 name: alkyl sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602] synonym: "alkyl sulphatase activity" EXACT [] xref: EC:3.1.6 xref: UM-BBD_reactionID:r0602 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0018742 name: epoxide hydrolase B activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] xref: EC:3.3.2 xref: UM-BBD_enzymeID:e0051 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018743 name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560] xref: EC:3.3.2 xref: UM-BBD_reactionID:r0560 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018744 name: limonene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8] xref: EC:3.3.2.8 xref: MetaCyc:3.3.2.8-RXN xref: RHEA:10700 xref: UM-BBD_reactionID:r0734 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018745 name: epoxide hydrolase A activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] xref: EC:3.3.2 xref: UM-BBD_enzymeID:e0049 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018746 name: phenanthrene-3,4-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535] xref: UM-BBD_reactionID:r0535 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018747 name: phenanthrene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536] xref: UM-BBD_reactionID:r0536 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018748 name: iprodione amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706] xref: UM-BBD_reactionID:r0706 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018749 name: (3,5-dichlorophenylurea)acetate amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708] xref: UM-BBD_reactionID:r0708 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018750 name: biuret amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] xref: EC:3.5.1.84 xref: RHEA:17525 xref: UM-BBD_reactionID:r0846 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018751 name: 3,5-dichlorophenylcarboximide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707] xref: UM-BBD_reactionID:r0707 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018752 name: epsilon-caprolactam lactamase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448] xref: MetaCyc:R561-RXN xref: UM-BBD_reactionID:r0448 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018753 name: cyanuric acid amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] xref: EC:3.5.2.15 xref: MetaCyc:R468-RXN xref: RHEA:14641 xref: UM-BBD_reactionID:r0116 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018754 name: ammelide aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] xref: MetaCyc:RXN-8017 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018755 name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018756 name: ammeline aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] xref: MetaCyc:RXN-8016 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018757 name: deisopropylhydroxyatrazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121] xref: KEGG_REACTION:R05574 xref: UM-BBD_reactionID:r0121 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018758 name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122] xref: UM-BBD_reactionID:r0122 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018759 name: methenyltetrahydromethanopterin cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19053] synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27] synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] xref: EC:3.5.4.27 xref: KEGG_REACTION:R03464 xref: MetaCyc:3.5.4.27-RXN xref: RHEA:19053 xref: UM-BBD_reactionID:r0347 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0018760 name: thiocyanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21464] synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8] xref: EC:3.5.5.8 xref: KEGG_REACTION:R05780 xref: MetaCyc:RXN-1761 xref: RHEA:21464 xref: UM-BBD_reactionID:r0598 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0018761 name: bromoxynil nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22100] synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] synonym: "bromoxynil-specific nitrilase activity" EXACT [] xref: EC:3.5.5.6 xref: KEGG_REACTION:R04349 xref: MetaCyc:3.5.5.6-RXN xref: RHEA:22100 xref: UM-BBD_enzymeID:e0357 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018762 name: aliphatic nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] xref: EC:3.5.5.7 xref: MetaCyc:3.5.5.7-RXN xref: UM-BBD_reactionID:r0622 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018763 name: hydroxydechloroatrazine ethylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.4.43] synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.4.43] synonym: "AtzB" RELATED [] synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.4.43] xref: EC:3.5.4.43 xref: MetaCyc:R122-RXN xref: RHEA:23092 xref: UM-BBD_enzymeID:e0085 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018764 name: N-isopropylammelide isopropylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.4.42] synonym: "AtzC" RELATED [] xref: EC:3.5.4.42 xref: MetaCyc:R123-RXN xref: RHEA:23608 xref: UM-BBD_enzymeID:e0086 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018765 name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263] xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN xref: UM-BBD_reactionID:r0263 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018766 name: dihydrophloroglucinol hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008] xref: KEGG_REACTION:R07831 xref: MetaCyc:R6-RXN xref: UM-BBD_reactionID:r0008 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018767 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399] xref: UM-BBD_reactionID:r0399 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018768 name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458] xref: EC:3.7.1.13 xref: UM-BBD_reactionID:r0458 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018769 name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311] xref: UM-BBD_reactionID:r0311 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018770 name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444] xref: UM-BBD_reactionID:r0444 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018771 name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity namespace: molecular_function alt_id: GO:0008680 def: "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:24789] synonym: "(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14] synonym: "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r0438] xref: EC:3.7.1.14 xref: MetaCyc:MHPCHYDROL-RXN xref: RHEA:24789 xref: UM-BBD_reactionID:r0438 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018772 name: trioxoheptanoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094] xref: MetaCyc:R306-RXN xref: UM-BBD_reactionID:r0094 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018773 name: acetylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16097] synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6] xref: EC:3.7.1.6 xref: KEGG_REACTION:R00324 xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN xref: RHEA:16097 xref: UM-BBD_reactionID:r0095 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018774 name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8] synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8] xref: EC:3.7.1.8 xref: MetaCyc:3.7.1.8-RXN xref: RHEA:17161 xref: UM-BBD_enzymeID:e0033 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018775 name: 2-hydroxymuconate-semialdehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9] synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9] synonym: "HMSH" RELATED [EC:3.7.1.9] synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9] xref: EC:3.7.1.9 xref: MetaCyc:3.7.1.9-RXN xref: RHEA:14549 xref: UM-BBD_enzymeID:e0139 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018776 name: trans-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689] xref: UM-BBD_reactionID:r0689 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018777 name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018778 name: DL-2 haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382] xref: EC:3.8.1.10 xref: MetaCyc:RXN-9150 xref: UM-BBD_reactionID:r0382 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018779 name: obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity" EXACT [] is_obsolete: true [Term] id: GO:0018780 name: dichloroacetate halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_reactionID:r0383] xref: UM-BBD_reactionID:r0383 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018781 name: S-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] xref: UM-BBD_enzymeID:e0091 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018782 name: cis-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688] xref: UM-BBD_reactionID:r0688 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018783 name: deisopropyldeethylatrazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018784 name: (S)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloacid dehalogenase activity" EXACT [] synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2] synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "L-DEX activity" EXACT [EC:3.8.1.2] xref: EC:3.8.1.2 xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN xref: UM-BBD_reactionID:r0090 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018785 name: haloacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] xref: EC:3.8.1.3 xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0006 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018786 name: haloalkane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5] synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5] xref: EC:3.8.1.5 xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN xref: RHEA:25185 xref: UM-BBD_enzymeID:e0003 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018787 name: 4-chlorobenzoyl-CoA dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7] xref: EC:3.8.1.7 xref: MetaCyc:3.8.1.7-RXN xref: RHEA:14853 xref: UM-BBD_enzymeID:e0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018788 name: atrazine chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11312] synonym: "AtzA" RELATED [EC:3.8.1.8] xref: EC:3.8.1.8 xref: KEGG_REACTION:R05558 xref: MetaCyc:3.8.1.8-RXN xref: RHEA:11312 xref: UM-BBD_reactionID:r0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018789 name: cyclamate sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18481] synonym: "cyclamate sulfamatase activity" EXACT [] synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclamate sulphohydrolase activity" EXACT [] synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2] xref: EC:3.10.1.2 xref: KEGG_REACTION:R02564 xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN xref: RHEA:18481 xref: UM-BBD_reactionID:r0755 is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0018791 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398] xref: UM-BBD_reactionID:r0398 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018792 name: bis(4-chlorophenyl)acetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520] synonym: "DDA decarboxylase activity" EXACT [] xref: UM-BBD_reactionID:r0520 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018793 name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546] xref: UM-BBD_reactionID:r0546 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018794 name: 2-hydroxyisobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617] xref: UM-BBD_reactionID:r0617 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018795 name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621] xref: UM-BBD_reactionID:r0621 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018796 name: 4,5-dihydroxyphthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55] xref: EC:4.1.1.55 xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN xref: RHEA:24184 xref: UM-BBD_enzymeID:e0106 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018798 name: gallate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol." [EC:4.1.1.59, RHEA:12749] synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59] synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59] synonym: "gallic acid decarboxylase activity" EXACT [] xref: EC:4.1.1.59 xref: KEGG_REACTION:R03247 xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN xref: RHEA:12749 xref: UM-BBD_reactionID:r0005 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018799 name: 4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol." [EC:4.1.1.61, RHEA:10876] synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61] synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61] synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61] xref: EC:4.1.1.61 xref: KEGG_REACTION:R01238 xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN xref: RHEA:10876 xref: UM-BBD_reactionID:r0159 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018800 name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68] synonym: "HpaG-2" RELATED [] synonym: "HpaG2" RELATED [] synonym: "OPET decarboxylase activity" EXACT [] xref: EC:4.1.1.68 xref: MetaCyc:4.1.1.68-RXN xref: RHEA:14397 xref: UM-BBD_reactionID:r0367 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018801 name: glutaconyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [EC:7.2.4.5, RHEA:23972] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:7.2.4.5] synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:7.2.4.5] synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:7.2.4.5] xref: EC:7.2.4.5 xref: KEGG_REACTION:R03028 xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN xref: RHEA:23972 xref: UM-BBD_reactionID:r0199 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018802 name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_reactionID:r0370] xref: EC:4.1.2 xref: UM-BBD_reactionID:r0370 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018803 name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34] synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] xref: EC:4.1.2.34 xref: MetaCyc:4.1.2.34-RXN xref: RHEA:16453 xref: UM-BBD_reactionID:r0487 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018805 name: benzylsuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10416] synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11] synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11] xref: EC:4.1.99.11 xref: KEGG_REACTION:R05598 xref: MetaCyc:RXN-863 xref: RHEA:10416 xref: UM-BBD_enzymeID:e0259 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0018807 name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204] xref: EC:3.7.1.21 xref: RHEA:39651 xref: UM-BBD_reactionID:r0204 is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: GO:0018808 name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484] xref: UM-BBD_reactionID:r0484 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018809 name: E-phenylitaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331] xref: UM-BBD_reactionID:r0331 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018810 name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164] xref: UM-BBD_reactionID:r0164 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018811 name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191] xref: MetaCyc:R266-RXN xref: UM-BBD_reactionID:r0191 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018812 name: 3-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] xref: Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018813 name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] xref: EC:4.1.2.45 xref: RHEA:27389 xref: UM-BBD_enzymeID:e0257 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018814 name: phenylacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20069] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7] synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7] synonym: "OxdB" RELATED [EC:4.99.1.7] synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7] xref: EC:4.99.1.7 xref: KEGG_REACTION:R07638 xref: MetaCyc:4.99.1.7-RXN xref: RHEA:20069 xref: UM-BBD_reactionID:r0697 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0018815 name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051] xref: MetaCyc:RXN-645 xref: UM-BBD_reactionID:r0051 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018816 name: 2-hydroxyisobutyrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_reactionID:r0618] xref: UM-BBD_reactionID:r0618 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018817 name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369] synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] synonym: "HpaH" RELATED [] xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN xref: UM-BBD_reactionID:r0369 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018818 name: acetylene hydratase activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O." [EC:4.2.1.112, RHEA:17885] synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112] synonym: "AH" RELATED [EC:4.2.1.112] synonym: "AHy" RELATED [EC:4.2.1.112] xref: EC:4.2.1.112 xref: KEGG_REACTION:R05380 xref: MetaCyc:R141-RXN xref: RHEA:17885 xref: UM-BBD_reactionID:r0591 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018819 name: lactoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54] synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54] xref: EC:4.2.1.54 xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN xref: MetaCyc:RXN-781 xref: RHEA:21056 xref: UM-BBD_reactionID:r0086 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018820 name: cyanamide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: urea = cyanamide + H(2)O." [EC:4.2.1.69, RHEA:23056] synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69] synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69] xref: EC:4.2.1.69 xref: KEGG_REACTION:R00778 xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN xref: RHEA:23056 xref: UM-BBD_reactionID:r0668 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018822 name: nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84] synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84] synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84] synonym: "H-NHase activity" EXACT [EC:4.2.1.84] synonym: "L-NHase activity" EXACT [EC:4.2.1.84] synonym: "NHase activity" EXACT [EC:4.2.1.84] synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84] xref: EC:4.2.1.84 xref: MetaCyc:NITRILE-HYDRATASE-RXN xref: RHEA:12673 xref: UM-BBD_enzymeID:e0067 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018823 name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21856] synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100] synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100] xref: EC:4.2.1.100 xref: KEGG_REACTION:R05597 xref: MetaCyc:4.2.1.100-RXN xref: RHEA:21856 xref: UM-BBD_reactionID:r0203 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018824 name: (hydroxyamino)benzene mutase activity namespace: molecular_function def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304] synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] xref: MetaCyc:5.4.4.1-RXN xref: UM-BBD_reactionID:r0304 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0018825 name: triethanolamine lyase activity namespace: molecular_function def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] xref: UM-BBD_enzymeID:e0421 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0018826 name: methionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11] synonym: "L-methioninase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11] synonym: "methioninase activity" EXACT [EC:4.4.1.11] synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11] synonym: "methionine lyase activity" EXACT [EC:4.4.1.11] xref: EC:4.4.1.11 xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN xref: RHEA:24750 xref: UM-BBD_reactionID:r0432 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0018827 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515] synonym: "DDMS dehydrochlorinase activity" EXACT [] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0515 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018828 name: halohydrin hydrogen-halide-lyase A activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] xref: UM-BBD_enzymeID:e0048 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018829 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513] synonym: "DDD dehydrochlorinase activity" EXACT [] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0513 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018830 name: gamma-hexachlorocyclohexane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] xref: EC:4.5.1 xref: UM-BBD_enzymeID:e0359 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018831 name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0666 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018832 name: halohydrin hydrogen-halide-lyase B activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] xref: UM-BBD_enzymeID:e0050 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018833 name: DDT-dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19217] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1] synonym: "DDT dehydrochlorinase activity" EXACT [] synonym: "DDT-as" RELATED [EC:4.5.1.1] synonym: "DDT-ase activity" EXACT [EC:4.5.1.1] synonym: "DDTase activity" EXACT [EC:4.5.1.1] xref: EC:4.5.1.1 xref: KEGG_REACTION:R04522 xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN xref: RHEA:19217 xref: UM-BBD_reactionID:r0439 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018834 name: dichloromethane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15397] synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3] synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3] xref: EC:4.5.1.3 xref: KEGG_REACTION:R00603 xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN xref: RHEA:15397 xref: UM-BBD_reactionID:r0188 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018835 name: carbon phosphorus lyase activity namespace: molecular_function alt_id: GO:0009456 def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975] xref: EC:4.7.1 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018836 name: alkylmercury lyase activity namespace: molecular_function def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] xref: EC:4.99.1.2 xref: MetaCyc:ALKYLMERCURY-LYASE-RXN xref: UM-BBD_enzymeID:e0055 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018837 name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502] xref: UM-BBD_reactionID:r0502 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018838 name: mandelate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] xref: EC:5.1.2.2 xref: MetaCyc:MANDELATE-RACEMASE-RXN xref: RHEA:13945 xref: UM-BBD_reactionID:r0091 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018839 name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163] xref: EC:5.2.1 xref: UM-BBD_reactionID:r0163 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0018842 name: 3-carboxymuconate cycloisomerase type II activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_reactionID:r0582] xref: EC:5.5.1.2 xref: RHEA:23656 xref: UM-BBD_reactionID:r0582 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018844 name: 2-hydroxytetrahydrofuran isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019] xref: EC:5.3.99 xref: UM-BBD_reactionID:r0019 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018845 name: 2-hydroxychromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27401] xref: EC:5.99.1.4 xref: KEGG_REACTION:R05137 xref: MetaCyc:RXNN-386 xref: RHEA:27401 xref: UM-BBD_reactionID:r0337 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018846 name: styrene-oxide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21604] synonym: "SOI activity" EXACT [EC:5.3.99.7] synonym: "styrene oxide isomerase activity" EXACT [] synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7] xref: EC:5.3.99.7 xref: KEGG_REACTION:R02615 xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN xref: RHEA:21604 xref: UM-BBD_reactionID:r0034 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018847 name: alpha-pinene lyase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712] xref: EC:5.5.1 xref: UM-BBD_reactionID:r0712 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018848 name: pinocarveol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715] xref: EC:5.5.1 xref: UM-BBD_reactionID:r0715 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018849 name: muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1] synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1] synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1] xref: EC:5.5.1.1 xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN xref: RHEA:10640 xref: UM-BBD_enzymeID:e0133 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018850 name: chloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7] synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7] xref: EC:5.5.1.7 xref: RHEA:11032 xref: UM-BBD_enzymeID:e0065 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018851 name: alpha-pinene-oxide decyclase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16693] synonym: "alpha-pinene oxide lyase activity" EXACT [] synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10] xref: EC:5.5.1.10 xref: KEGG_REACTION:R04040 xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN xref: RHEA:16693 xref: UM-BBD_reactionID:r0743 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018852 name: dichloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11] xref: EC:5.5.1.11 xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN xref: RHEA:17437 xref: UM-BBD_reactionID:r0277 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018853 name: obsolete perillyl-CoA synthetase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731] comment: This term was made obsolete because it represents two reactions. synonym: "perillyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1 xref: UM-BBD_reactionID:r0731 is_obsolete: true consider: GO:0052685 consider: GO:0052686 [Term] id: GO:0018854 name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737] xref: UM-BBD_reactionID:r0737 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018855 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429] xref: EC:6.2.1.38 xref: UM-BBD_reactionID:r0429 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018856 name: benzoyl acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242] xref: KEGG_REACTION:R05452 xref: SABIO-RK:5058 xref: UM-BBD_reactionID:r0242 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018857 name: 2,4-dichlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137] xref: UM-BBD_reactionID:r0137 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018858 name: benzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10132] synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25] xref: EC:6.2.1.25 xref: KEGG_REACTION:R01422 xref: MetaCyc:BENZOATE--COA-LIGASE-RXN xref: RHEA:10132 xref: UM-BBD_reactionID:r0189 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018859 name: 4-hydroxybenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27] xref: EC:6.2.1.27 xref: KEGG_REACTION:R01300 xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN xref: RHEA:23116 xref: UM-BBD_reactionID:r0156 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018860 name: anthranilate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "anthranilate--CoA ligase activity" EXACT [] synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32] synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32] xref: EC:6.2.1.32 xref: KEGG_REACTION:R00982 xref: MetaCyc:AMINOBENZCOALIG-RXN xref: RHEA:10828 xref: UM-BBD_reactionID:r0341 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018861 name: 4-chlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] xref: EC:6.2.1.33 xref: KEGG_REACTION:R03932 xref: MetaCyc:6.2.1.33-RXN xref: RHEA:23220 xref: UM-BBD_reactionID:r0139 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018862 name: phenylphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157] xref: EC:6.4.1 xref: MetaCyc:PHENYLPCARB-RXN xref: UM-BBD_reactionID:r0157 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018863 name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496] xref: EC:3.3.2 xref: UM-BBD_reactionID:r0496 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018864 name: acetylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544] synonym: "acetylene metabolism" EXACT [] synonym: "ethyne metabolic process" EXACT [] synonym: "ethyne metabolism" EXACT [] xref: UM-BBD_pathwayID:atl is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043452 ! cellular alkyne metabolic process [Term] id: GO:0018865 name: acrylonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm] synonym: "acrylonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:acr is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018866 name: adamantanone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] synonym: "adamantanone metabolism" EXACT [] xref: UM-BBD_pathwayID:ada is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018867 name: alpha-pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn] synonym: "alpha-pinene metabolism" EXACT [] xref: UM-BBD_pathwayID:apn is_a: GO:0033073 ! pinene metabolic process [Term] id: GO:0018868 name: 2-aminobenzenesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] synonym: "2-aminobenzenesulfonate metabolism" EXACT [] synonym: "2-aminobenzenesulphonate metabolic process" EXACT [] synonym: "2-aminobenzenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:abs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018870 name: anaerobic 2-aminobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic 2-aminobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:abz is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043420 ! anthranilate metabolic process [Term] id: GO:0018871 name: 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp] synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT [] synonym: "ACP metabolic process" EXACT [] synonym: "ACP metabolism" EXACT [] xref: UM-BBD_pathwayID:acp is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0018872 name: arsonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara] synonym: "arsonoacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:ara is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018873 name: atrazine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr] synonym: "atrazine metabolism" EXACT [] xref: UM-BBD_pathwayID:atr is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0018965 ! s-triazine compound metabolic process [Term] id: GO:0018874 name: benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544] synonym: "benzoate metabolism" EXACT [] xref: MetaCyc:P321-PWY xref: UM-BBD_pathwayID:benz2 is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018875 name: anaerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic benzoate metabolism" EXACT [] xref: MetaCyc:CENTBENZCOA-PWY xref: UM-BBD_pathwayID:benz is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0018876 name: benzonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn] synonym: "benzonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:bzn is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018877 name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch] synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: UM-BBD_pathwayID:hch is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018878 name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai] synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process [Term] id: GO:0018879 name: biphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl] synonym: "biphenyl metabolism" EXACT [] synonym: "xenene metabolic process" EXACT [] synonym: "xenene metabolism" EXACT [] xref: UM-BBD_pathwayID:bph is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018880 name: 4-chlorobiphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl] synonym: "4-chlorobiphenyl metabolism" EXACT [] xref: UM-BBD_pathwayID:cbp is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018881 name: bromoxynil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] synonym: "bromoxynil metabolism" EXACT [] xref: UM-BBD_pathwayID:box is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018882 name: (+)-camphor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam] synonym: "(+)-camphor metabolism" EXACT [] synonym: "camphor metabolic process" EXACT [] synonym: "camphor metabolism" EXACT [] xref: UM-BBD_pathwayID:cam is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018883 name: caprolactam metabolic process namespace: biological_process def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [GOC:curators] synonym: "caprolactam metabolism" EXACT [] xref: UM-BBD_pathwayID:cap is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0072338 ! cellular lactam metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018884 name: carbazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl] synonym: "CAR metabolic process" EXACT [] synonym: "CAR metabolism" EXACT [] synonym: "carbazole metabolism" EXACT [] xref: UM-BBD_pathwayID:car is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018885 name: carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc] synonym: "carbon tetrachloride metabolism" EXACT [] xref: UM-BBD_pathwayID:ctc is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018886 name: anaerobic carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic carbon tetrachloride metabolism" EXACT [] xref: UM-BBD_pathwayID:ctc is_a: GO:0018885 ! carbon tetrachloride metabolic process [Term] id: GO:0018887 name: 4-carboxy-4'-sulfoazobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860] synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:csab is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018888 name: 3-chloroacrylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai] synonym: "3-chloroacrylic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:caa is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018889 name: 2-chloro-N-isopropylacetanilide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc] synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] synonym: "propachlor metabolic process" EXACT [] synonym: "propachlor metabolism" EXACT [] xref: UM-BBD_pathwayID:ppc is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018890 name: cyanamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [GOC:curators] synonym: "cyanamide metabolism" EXACT [] xref: UM-BBD_pathwayID:cnm is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018891 name: cyclohexanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544] synonym: "cyclohexanol metabolism" EXACT [] xref: UM-BBD_pathwayID:chx is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0018892 name: cyclohexylsulfamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs] synonym: "cyclohexylsulfamate metabolism" EXACT [] synonym: "cyclohexylsulphamate metabolic process" EXACT [] synonym: "cyclohexylsulphamate metabolism" EXACT [] xref: UM-BBD_pathwayID:chs is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018893 name: dibenzofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf] synonym: "dibenzofuran metabolism" EXACT [] xref: UM-BBD_pathwayID:dbf is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018894 name: dibenzo-p-dioxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd] synonym: "dibenzo-p-dioxin metabolism" EXACT [] synonym: "oxanthrene metabolic process" EXACT [] synonym: "oxanthrene metabolism" EXACT [] synonym: "phenodioxin metabolic process" EXACT [] synonym: "phenodioxin metabolism" EXACT [] xref: UM-BBD_pathwayID:dpd is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018895 name: dibenzothiophene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483] synonym: "dibenzothiophene metabolism" EXACT [] synonym: "diphenylene sulfide metabolic process" EXACT [] synonym: "diphenylene sulfide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018896 name: dibenzothiophene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzothiophene breakdown" EXACT [] synonym: "dibenzothiophene catabolism" EXACT [] synonym: "dibenzothiophene degradation" EXACT [] xref: UM-BBD_pathwayID:dbt2 is_a: GO:0018895 ! dibenzothiophene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0018897 name: dibenzothiophene desulfurization namespace: biological_process def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzothiophene desulphurization" EXACT [] xref: MetaCyc:PWY-681 xref: UM-BBD_pathwayID:dbt is_a: GO:0018895 ! dibenzothiophene metabolic process [Term] id: GO:0018898 name: 2,4-dichlorobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb] synonym: "2,4-dichlorobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:dcb is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018899 name: 1,2-dichloroethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl] synonym: "1,2-dichloroethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dce is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018900 name: dichloromethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm] synonym: "dichloromethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dcm is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018901 name: 2,4-dichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] synonym: "2,4-D metabolic process" EXACT [] synonym: "2,4-D metabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4-d is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018902 name: 1,3-dichloro-2-propanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp] synonym: "1,3-dichloro-2-propanol metabolism" EXACT [] synonym: "DCP metabolic process" EXACT [] synonym: "DCP metabolism" EXACT [] xref: UM-BBD_pathwayID:dcp is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0018903 name: 1,3-dichloropropene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr] synonym: "1,3-dichloropropene metabolism" EXACT [] synonym: "1,3-dichloropropylene metabolic process" EXACT [] synonym: "1,3-dichloropropylene metabolism" EXACT [] synonym: "gamma-chloroallylchloride metabolic process" EXACT [] synonym: "gamma-chloroallylchloride metabolism" EXACT [] xref: UM-BBD_pathwayID:cpr is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018904 name: ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732] subset: goslim_pir synonym: "ether metabolism" EXACT [] synonym: "organic ether metabolic process" EXACT [] synonym: "organic ether metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018905 name: dimethyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme] synonym: "dimethyl ether metabolism" EXACT [] synonym: "methyl ether metabolic process" EXACT [] synonym: "methyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:dme is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0018906 name: methyl tert-butyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb] synonym: "methyl tert-butyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:mtb is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0018907 name: dimethyl sulfoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [GOC:curators] synonym: "dimethyl sulfoxide metabolism" EXACT [] synonym: "dimethyl sulphoxide metabolic process" EXACT [] synonym: "dimethyl sulphoxide metabolism" EXACT [] synonym: "DMSO metabolic process" EXACT [] synonym: "DMSO metabolism" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018908 name: organosulfide cycle namespace: biological_process def: "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf] synonym: "organosulphide cycle" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018909 name: dodecyl sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds] synonym: "dodecyl sulfate metabolism" EXACT [] synonym: "dodecyl sulphate metabolic process" EXACT [] synonym: "dodecyl sulphate metabolism" EXACT [] xref: UM-BBD_pathwayID:dds is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018910 name: benzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [GOC:ai] synonym: "benzene metabolism" EXACT [] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018911 name: 1,2,4-trichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm] synonym: "1,2,4-trichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:tbz is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018912 name: 1,4-dichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] synonym: "1,4-dichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:dcz is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018913 name: anaerobic ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb is_a: GO:0018915 ! ethylbenzene metabolic process [Term] id: GO:0018914 name: chlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/] synonym: "chlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:cb is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018915 name: ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm] synonym: "ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb2 is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018916 name: nitrobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [GOC:curators] synonym: "nitrobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:nb is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018917 name: fluorene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [UM-BBD_pathwayID:flu] synonym: "fluorene metabolism" EXACT [] xref: UM-BBD_pathwayID:flu is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018918 name: gallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732] synonym: "gallate metabolism" EXACT [] synonym: "gallic acid metabolic process" EXACT [] synonym: "gallic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:gal is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018919 name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch] synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: MetaCyc:GAMMAHEXCHLORDEG-PWY xref: UM-BBD_pathwayID:ghch is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018920 name: glyphosate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly] synonym: "glyphosate metabolism" EXACT [] synonym: "Roundup metabolic process" EXACT [] synonym: "Roundup metabolism" EXACT [] xref: UM-BBD_pathwayID:gly is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018921 name: 3-hydroxybenzyl alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr] synonym: "3-hydroxybenzyl alcohol metabolism" EXACT [] xref: UM-BBD_pathwayID:mcr is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018922 name: iprodione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd] synonym: "iprodione metabolism" EXACT [] xref: UM-BBD_pathwayID:ipd is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process [Term] id: GO:0018923 name: limonene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim] synonym: "limonene metabolism" EXACT [] xref: UM-BBD_pathwayID:lim is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018924 name: mandelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl] synonym: "mandelate metabolism" EXACT [] synonym: "mandelic acid metabolic process" EXACT [] synonym: "mandelic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:mca is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0018925 name: m-cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl] synonym: "3-hydroxytoluene metabolic process" EXACT [] synonym: "3-hydroxytoluene metabolism" EXACT [] synonym: "m-cresol metabolism" EXACT [] synonym: "meta-cresol metabolic process" EXACT [] synonym: "meta-cresol metabolism" EXACT [] xref: MetaCyc:M-CRESOL-DEGRADATION-PWY xref: UM-BBD_pathwayID:mcr is_a: GO:0042212 ! cresol metabolic process [Term] id: GO:0018926 name: methanesulfonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa] synonym: "methanesulfonic acid metabolism" EXACT [] synonym: "methanesulphonic acid metabolic process" EXACT [] synonym: "methanesulphonic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:msa is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process [Term] id: GO:0018927 name: obsolete methionine and threonine metabolic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule. synonym: "methionine and threonine metabolic process" EXACT [] is_obsolete: true consider: GO:0006555 consider: GO:0006566 [Term] id: GO:0018928 name: methyl ethyl ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [UM-BBD_pathwayID:mek] synonym: "2-butanone metabolic process" EXACT [] synonym: "2-butanone metabolism" EXACT [] synonym: "MEK metabolic process" EXACT [] synonym: "MEK metabolism" EXACT [] synonym: "methyl ethyl ketone metabolism" EXACT [] xref: UM-BBD_pathwayID:mek is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018929 name: methyl fluoride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf] synonym: "methyl fluoride metabolism" EXACT [] xref: UM-BBD_pathwayID:mf is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018930 name: 3-methylquinoline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] synonym: "3-methylquinoline metabolism" EXACT [] xref: UM-BBD_pathwayID:mqn is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018931 name: naphthalene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm] synonym: "naphthalene metabolism" EXACT [] xref: UM-BBD_pathwayID:naph is_a: GO:0017144 ! drug metabolic process is_a: GO:0090420 ! naphthalene-containing compound metabolic process [Term] id: GO:0018933 name: nicotine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0018934 name: nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta] synonym: "nitrilotriacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:nta is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018935 name: aerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai] synonym: "aerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018936 name: anaerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018937 name: nitroglycerin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [UM-BBD_pathwayID:ng] synonym: "NG metabolic process" EXACT [] synonym: "NG metabolism" EXACT [] synonym: "nitroglycerin metabolism" EXACT [] xref: MetaCyc:P201-PWY xref: UM-BBD_pathwayID:ng is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018938 name: 2-nitropropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [UM-BBD_pathwayID:npp] synonym: "2-nitropropane metabolism" EXACT [] xref: MetaCyc:PWY-723 xref: UM-BBD_pathwayID:npp is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018939 name: n-octane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct] synonym: "n-octane metabolism" EXACT [] xref: UM-BBD_pathwayID:oct is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0018940 name: orcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl] synonym: "orcin metabolic process" EXACT [] synonym: "orcin metabolism" EXACT [] synonym: "orcinol metabolism" EXACT [] xref: MetaCyc:P342-PWY xref: UM-BBD_pathwayID:orc is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018941 name: organomercury metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732] synonym: "organomercury metabolism" EXACT [] xref: UM-BBD_pathwayID:ogm is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018942 name: organometal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732] subset: goslim_pir synonym: "organometal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018943 name: organotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732] synonym: "organotin metabolism" EXACT [] is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018944 name: tri-n-butyltin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt] synonym: "tri-n-butyltin metabolism" EXACT [] xref: UM-BBD_pathwayID:tbt is_a: GO:0018943 ! organotin metabolic process [Term] id: GO:0018945 name: organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl] synonym: "organosilicon metabolism" EXACT [] synonym: "organosilicone metabolic process" EXACT [] synonym: "organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018946 name: aerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl] synonym: "aerobic organosilicon metabolism" EXACT [] synonym: "aerobic organosilicone metabolic process" EXACT [] synonym: "aerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018947 name: anaerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl] synonym: "anaerobic organosilicon metabolism" EXACT [] synonym: "anaerobic organosilicone metabolic process" EXACT [] synonym: "anaerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018948 name: xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl] synonym: "xylene metabolism" EXACT [] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018949 name: m-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "m-xylene metabolism" EXACT [] synonym: "meta-xylene metabolic process" EXACT [] synonym: "meta-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:mxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018950 name: o-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "o-xylene metabolism" EXACT [] synonym: "ortho-xylene metabolic process" EXACT [] synonym: "ortho-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:oxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018951 name: p-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "p-xylene metabolism" EXACT [] synonym: "para-xylene metabolic process" EXACT [] synonym: "para-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018952 name: parathion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] synonym: "parathion metabolism" EXACT [] xref: UM-BBD_pathwayID:pthn is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0018953 name: p-cymene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy] synonym: "p-cymene metabolism" EXACT [] xref: UM-BBD_pathwayID:pcy is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018954 name: pentaerythritol tetranitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn] synonym: "pentaerythritol tetranitrate metabolism" EXACT [] xref: UM-BBD_pathwayID:petn is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018955 name: phenanthrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, UM-BBD_pathwayID:pha] synonym: "phenanthrene metabolism" EXACT [] xref: UM-BBD_pathwayID:pha is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018956 name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha3] synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha3 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018957 name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha2] synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha2 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0018959 name: aerobic phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [ISBN:0198506732] synonym: "aerobic phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:pba is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018960 name: 4-nitrophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl] synonym: "4-nitrophenol metabolism" EXACT [] synonym: "p-nitrophenol metabolic process" EXACT [] synonym: "p-nitrophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:nphe is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018961 name: pentachlorophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [UM-BBD_pathwayID:pcp] synonym: "PCP metabolic process" EXACT [] synonym: "PCP metabolism" EXACT [] synonym: "pentachlorophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:pcp is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018962 name: 3-phenylpropionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa] synonym: "3-phenylpropionate metabolism" EXACT [] synonym: "hydrocinnamic acid metabolic process" EXACT [] synonym: "hydrocinnamic acid metabolism" EXACT [] synonym: "phenylpropanoate metabolic process" EXACT [] synonym: "phenylpropanoate metabolism" EXACT [] xref: UM-BBD_pathwayID:ppa is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018963 name: phthalate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [UM-BBD_pathwayID:pth] synonym: "phthalate metabolism" EXACT [] synonym: "phthalic acid metabolic process" EXACT [] synonym: "phthalic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:pth is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0018964 name: propylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl] synonym: "propylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pro is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0018965 name: s-triazine compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria] synonym: "s-triazine compound metabolism" EXACT [] xref: UM-BBD_pathwayID:tria is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018966 name: styrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, UM-BBD_pathwayID:sty] synonym: "styrene metabolism" EXACT [] xref: UM-BBD_pathwayID:sty is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1900673 ! olefin metabolic process [Term] id: GO:0018967 name: tetrachloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm] synonym: "tetrachloroethene metabolic process" EXACT [] synonym: "tetrachloroethene metabolism" EXACT [] synonym: "tetrachloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce2 is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018968 name: tetrahydrofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf] synonym: "tetrahydrofuran metabolism" EXACT [] synonym: "THF metabolic process" EXACT [] synonym: "THF metabolism" EXACT [] xref: UM-BBD_pathwayID:thf is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0097176 ! epoxide metabolic process [Term] id: GO:0018969 name: thiocyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl] synonym: "thiocyanate metabolism" EXACT [] synonym: "thiocyanic acid metabolic process" EXACT [] synonym: "thiocyanic acid metabolism" EXACT [] xref: MetaCyc:P581-PWY xref: UM-BBD_pathwayID:thc is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018970 name: toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [UM-BBD_pathwayID:tol] synonym: "methylbenzene metabolic process" EXACT [] synonym: "methylbenzene metabolism" EXACT [] synonym: "toluene metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018971 name: anaerobic toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic toluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tol2 is_a: GO:0018970 ! toluene metabolic process [Term] id: GO:0018972 name: toluene-4-sulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai] synonym: "4-methylbenzenesulfonate metabolic process" EXACT [] synonym: "4-methylbenzenesulfonate metabolism" EXACT [] synonym: "4-toluenesulfonate metabolic process" EXACT [] synonym: "4-toluenesulfonate metabolism" EXACT [] synonym: "toluene-4-sulfonate metabolism" EXACT [] synonym: "toluene-4-sulphonate metabolic process" EXACT [] synonym: "toluene-4-sulphonate metabolism" EXACT [] xref: MetaCyc:TOLSULFDEG-PWY xref: UM-BBD_pathwayID:tsa is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018973 name: trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] synonym: "trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0018974 name: 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767] synonym: "2,4,6-trinitrotoluene metabolism" EXACT [] synonym: "TNT metabolic process" EXACT [] synonym: "TNT metabolism" EXACT [] is_a: GO:0018973 ! trinitrotoluene metabolic process [Term] id: GO:0018975 name: anaerobic 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt2 is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0018976 name: 1,2,3-tribromopropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl] synonym: "1,2,3-tribromopropane metabolism" EXACT [] xref: UM-BBD_pathwayID:tbp is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018977 name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "DDT metabolic process" EXACT [] synonym: "DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018978 name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl] synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "anaerobic DDT metabolic process" EXACT [] synonym: "anaerobic DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt2 is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process [Term] id: GO:0018979 name: trichloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl] synonym: "TCE metabolic process" EXACT [] synonym: "TCE metabolism" EXACT [] synonym: "trichloroethene metabolic process" EXACT [] synonym: "trichloroethene metabolism" EXACT [] synonym: "trichloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018980 name: 2,4,5-trichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t] synonym: "2,4,5-T metabolic process" EXACT [] synonym: "2,4,5-T metabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4\,5-t is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018981 name: triethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl] synonym: "triethanolamine metabolism" EXACT [] xref: UM-BBD_pathwayID:tea is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0018982 name: vanillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl] synonym: "vanillic aldehyde metabolic process" EXACT [] synonym: "vanillic aldehyde metabolism" EXACT [] synonym: "vanillin metabolism" EXACT [] xref: UM-BBD_pathwayID:van is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018983 name: Z-phenylacetaldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car] synonym: "Z-phenylacetaldoxime metabolism" EXACT [] xref: UM-BBD_pathwayID:pao is_a: GO:0019330 ! aldoxime metabolic process [Term] id: GO:0018984 name: naphthalenesulfonate metabolic process namespace: biological_process alt_id: GO:0018932 def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai] synonym: "naphthalenesulfonate metabolism" EXACT [] synonym: "naphthalenesulphonate metabolic process" EXACT [] synonym: "naphthalenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:nphs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018985 name: pronuclear envelope synthesis namespace: biological_process def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems] is_a: GO:0006998 ! nuclear envelope organization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0018988 name: obsolete molting cycle, protein-based cuticle namespace: biological_process def: "OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_obsolete: true consider: GO:0007591 consider: GO:0018996 [Term] id: GO:0018989 name: apolysis namespace: biological_process def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl] xref: Wikipedia:Apolysis is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018990 name: ecdysis, chitin-based cuticle namespace: biological_process def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018991 name: oviposition namespace: biological_process def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] synonym: "egg laying" BROAD [] synonym: "egg-laying" BROAD [] xref: Wikipedia:Oviposition is_a: GO:0019098 ! reproductive behavior [Term] id: GO:0018992 name: germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0018993 name: somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0018995 name: host cellular component namespace: cellular_component def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0018996 name: molting cycle, collagen and cuticulin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0042303 ! molting cycle [Term] id: GO:0018997 name: obsolete electron transfer carrier namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the parent terms cover its function. synonym: "electron transfer carrier" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0018998 name: obsolete metaxin namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "metaxin" EXACT [] is_obsolete: true consider: GO:0005741 [Term] id: GO:0019000 name: obsolete endonuclease G activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691] comment: This term was made obsolete because it represents a gene product. synonym: "endonuclease G activity" EXACT [] is_obsolete: true consider: GO:0004520 consider: GO:0004521 [Term] id: GO:0019001 name: guanyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] xref: Reactome:R-HSA-156909 "eEF1A complexes with GTP" is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0019002 name: GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0019003 name: GDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0019005 name: SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "CDL1 complex" EXACT [] synonym: "CRL1 complex" EXACT [] synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] synonym: "cullin-RING ligase 1" EXACT [] synonym: "SCF complex" EXACT [] synonym: "SCF complex substrate recognition subunit" NARROW [] synonym: "Skp1/Cul1/F-box protein complex" EXACT [] xref: Wikipedia:SCF_complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0019008 name: molybdopterin synthase complex namespace: cellular_component alt_id: GO:0019009 def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] subset: goslim_metagenomics synonym: "molybdopterin converting factor complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019010 name: farnesoic acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0019011 name: obsolete DNA replication accessory factor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication accessory factor" EXACT [] is_obsolete: true consider: GO:0006260 [Term] id: GO:0019012 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0019013 name: viral nucleocapsid namespace: cellular_component alt_id: GO:0019014 def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] subset: goslim_chembl synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0019015 name: obsolete viral genome namespace: cellular_component def: "OBSOLETE. The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019016 name: obsolete non-segmented viral genome namespace: cellular_component def: "OBSOLETE. A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019017 name: obsolete segmented viral genome namespace: cellular_component def: "OBSOLETE. A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019018 name: obsolete bipartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019019 name: obsolete tripartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019020 name: obsolete multipartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019021 name: obsolete DNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019022 name: obsolete RNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019023 name: obsolete dsRNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of double stranded RNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019024 name: obsolete ssRNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019025 name: obsolete positive sense viral genome namespace: cellular_component def: "OBSOLETE. A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019026 name: obsolete negative sense viral genome namespace: cellular_component def: "OBSOLETE. A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019027 name: obsolete ambisense viral genome namespace: cellular_component def: "OBSOLETE. A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019028 name: viral capsid namespace: cellular_component alt_id: GO:0046728 def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_chembl xref: Wikipedia:Capsid is_a: GO:0044423 ! virion part [Term] id: GO:0019029 name: helical viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019030 name: icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure." [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid] synonym: "quasispherical viral capsid" EXACT [] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019031 name: viral envelope namespace: cellular_component def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] subset: goslim_chembl synonym: "viral glycoprotein" RELATED [] synonym: "viral outside membrane" EXACT [] xref: Wikipedia:Viral_envelope is_a: GO:0036338 ! viral membrane [Term] id: GO:0019032 name: obsolete viral glycoprotein namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a type of gene product and not a location or complex. synonym: "viral glycoprotein" EXACT [] is_obsolete: true consider: GO:0019031 [Term] id: GO:0019033 name: viral tegument namespace: cellular_component def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544] xref: Wikipedia:Viral_tegument is_a: GO:0044423 ! virion part [Term] id: GO:0019034 name: viral replication complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0019035 name: viral integration complex namespace: cellular_component def: "A nucleoprotein complex containing viral genetic material and associated viral and host proteins, which is capable of inserting a viral genome into a host genome." [ISBN:0781718325, PMID:16712776, Wikipedia:Pre-integration_complex] synonym: "PIC" EXACT [PMID:16712776] synonym: "pre-integration complex" EXACT [PMID:16712776] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0042025 ! host cell nucleus [Term] id: GO:0019036 name: viral transcriptional complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019037 name: viral assembly intermediate namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0019038 name: obsolete provirus namespace: cellular_component def: "OBSOLETE. The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. xref: Wikipedia:Provirus is_obsolete: true [Term] id: GO:0019039 name: obsolete viral-cell fusion molecule activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "viral-cell fusion molecule activity" EXACT [] is_obsolete: true consider: GO:0019064 consider: GO:0050839 [Term] id: GO:0019040 name: obsolete viral host shutoff protein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "viral host shutoff protein" EXACT [] is_obsolete: true consider: GO:0004534 consider: GO:0019057 [Term] id: GO:0019042 name: viral latency namespace: biological_process alt_id: GO:0030069 alt_id: GO:0075710 def: "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl] synonym: "latent virus infection" EXACT [] synonym: "phage lysogeny" EXACT [] synonym: "viral dormancy" EXACT [] is_a: GO:0016032 ! viral process [Term] id: GO:0019043 name: establishment of viral latency namespace: biological_process alt_id: GO:0075601 def: "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects." [GOC:jl] synonym: "lysogenic commitment" EXACT [] synonym: "phage lysogeny" NARROW [] xref: PHI:0000007 is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019044 name: maintenance of viral latency namespace: biological_process alt_id: GO:0032360 alt_id: GO:0075716 def: "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms." [GOC:jl] synonym: "latent virus maintenance" EXACT [] synonym: "prophage maintenance" EXACT [] synonym: "provirus maintenance" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019045 name: latent virus replication namespace: biological_process def: "Any process required for latent viral replication in a cell." [ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019046 name: release from viral latency namespace: biological_process alt_id: GO:0075717 def: "The process by which a virus begins to replicate following a latency replication decision (switch)." [GOC:dos, GOC:jl] is_a: GO:0016032 ! viral process relationship: part_of GO:0019045 ! latent virus replication [Term] id: GO:0019048 name: modulation by virus of host morphology or physiology namespace: biological_process alt_id: GO:0044792 def: "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945] synonym: "host-virus interaction" EXACT [GOC:bf, GOC:jl] synonym: "modulation by virus of host anatomical structure or process" EXACT [GOC:bf, GOC:jl] synonym: "modulation by virus of host anatomy or process" EXACT [GOC:bf, GOC:jl] synonym: "viral interaction with host" EXACT [] synonym: "viral-host process" EXACT [GOC:bf, GOC:jl] synonym: "virus-host interaction" BROAD [GOC:bf, GOC:jl] synonym: "virus-host process" EXACT [GOC:bf, GOC:jl] xref: VZ:886 "Vertebrate host-virus interactions" is_a: GO:0016032 ! viral process is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0019049 name: mitigation of host defenses by virus namespace: biological_process def: "A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272] synonym: "evasion of host defenses by virus" NARROW [GOC:bf, GOC:bm, GOC:jl] synonym: "evasion or tolerance of host defenses by virus" RELATED [] synonym: "viral host defence evasion" NARROW [] synonym: "viral host defense evasion" NARROW [] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0030682 ! mitigation of host defenses by symbiont [Term] id: GO:0019050 name: suppression by virus of host apoptotic process namespace: biological_process def: "Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication." [GOC:mtg_apoptosis, ISBN:0781718325] synonym: "negative regulation by virus of host apoptosis" EXACT [] synonym: "negative regulation of apoptosis by virus" EXACT [] synonym: "suppression by virus of host apoptosis" EXACT [] synonym: "suppression of apoptosis in host by virus" EXACT [] is_a: GO:0033668 ! negative regulation by symbiont of host apoptotic process is_a: GO:0039526 ! modulation by virus of host apoptotic process [Term] id: GO:0019051 name: induction by virus of host apoptotic process namespace: biological_process def: "The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions." [GOC:mtg_apoptosis, ISBN:0781718325] synonym: "activation by virus of host apoptosis" EXACT [] synonym: "activation by virus of host apoptotic programmed cell death" EXACT [] synonym: "activation of apoptosis in host by virus" EXACT [] synonym: "induction by virus of host apoptosis" NARROW [] synonym: "induction by virus of host apoptotic programmed cell death" EXACT [] synonym: "induction of apoptosis in host by virus" EXACT [] is_a: GO:0060139 ! positive regulation of apoptotic process by virus [Term] id: GO:0019054 name: modulation by virus of host cellular process namespace: biological_process def: "The process in which a virus effects a change in the processes and activities of its host organism." [GOC:jl] synonym: "modification by virus of host cellular process" EXACT [] synonym: "modulation by virus of host process" BROAD [] synonym: "modulation of cellular process in host by virus" RELATED [] synonym: "regulation by virus of host cellular process" EXACT [] synonym: "regulation of cellular process in host by virus" EXACT [] synonym: "regulation of host cellular process by virus" EXACT [] synonym: "viral host cell process manipulation" EXACT [] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0009987 ! cellular process [Term] id: GO:0019055 name: modification by virus of host cell cycle regulation namespace: biological_process def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325] synonym: "viral perturbation of cell cycle regulation" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0044071 ! modulation by symbiont of host cell cycle intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0022402 ! cell cycle process [Term] id: GO:0019056 name: modulation by virus of host transcription namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of its host's transcription." [ISBN:0781718325] synonym: "modification by virus of host transcription" EXACT [] synonym: "viral perturbation of host cell transcription" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0052026 ! modulation by symbiont of host transcription [Term] id: GO:0019057 name: modulation by virus of host translation namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325] synonym: "host cell protein synthesis shutoff" BROAD [] synonym: "host cell shutoff" BROAD [] synonym: "modification by virus of host cell mRNA translation" EXACT [] synonym: "modulation of host translation by virus" EXACT [GOC:bf] synonym: "regulation of host mRNA translation by virus" EXACT [] synonym: "regulation of host translation by virus" EXACT [] synonym: "regulation of translation in host by virus" EXACT [] synonym: "viral host shutoff protein" RELATED [] synonym: "viral perturbation of host cell mRNA translation" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0044073 ! modulation by symbiont of host translation [Term] id: GO:0019058 name: viral life cycle namespace: biological_process alt_id: GO:0019067 def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] synonym: "lytic viral life cycle" RELATED [] synonym: "viral assembly, maturation, egress, and release" NARROW [GOC:bf, GOC:jl] synonym: "viral infectious cycle" RELATED [GOC:bf, GOC:jl] synonym: "viral replication" RELATED [GOC:bf, GOC:jl] is_a: GO:0016032 ! viral process [Term] id: GO:0019059 name: obsolete initiation of viral infection namespace: biological_process def: "OBSOLETE. The set of processes involved in the start of virus infection of cells." [ISBN:0781702534] comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. synonym: "initiation of viral infection" EXACT [] is_obsolete: true consider: GO:0046718 [Term] id: GO:0019060 name: intracellular transport of viral protein in host cell namespace: biological_process alt_id: GO:0046742 alt_id: GO:0046743 alt_id: GO:0046801 def: "The directed movement of a viral protein within the host cell." [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566] comment: This term is for annotation of proteins responsible for the movement of individual viral proteins, rather than the whole viral particle. synonym: "cytoplasmic viral capsid transport" NARROW [] synonym: "intracellular transport of viral capsid in host cell" NARROW [] synonym: "intracellular transport of viral capsid protein in host cell" NARROW [] synonym: "intracellular transport of viral proteins in host cell" EXACT [] synonym: "intracellular viral capsid transport" NARROW [] synonym: "intracellular viral protein transport" EXACT [] synonym: "nuclear viral capsid transport" NARROW [] synonym: "viral capsid transport in host cell cytoplasm" NARROW [] synonym: "viral capsid transport in host cell nucleus" NARROW [] is_a: GO:0030581 ! symbiont intracellular protein transport in host relationship: part_of GO:0046719 ! regulation by virus of viral protein levels in host cell [Term] id: GO:0019061 name: uncoating of virus namespace: biological_process def: "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome." [GOC:plm, ISBN:0781702534, PMID:8162442] synonym: "viral uncoating" EXACT [PMID:8162442] is_a: GO:0016032 ! viral process [Term] id: GO:0019062 name: virion attachment to host cell namespace: biological_process def: "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956] synonym: "viral absorption" EXACT [] synonym: "viral attachment to host cell" RELATED [GOC:bf, GOC:jl] synonym: "virion attachment to host cell surface receptor" NARROW [] xref: VZ:956 "Viral attachment to host cell" is_a: GO:0044650 ! adhesion of symbiont to host cell relationship: has_part GO:0046790 ! virion binding relationship: has_part GO:0046812 ! host cell surface binding relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019064 name: fusion of virus membrane with host plasma membrane namespace: biological_process alt_id: GO:0075706 def: "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral envelope fusion" BROAD [] synonym: "viral envelope fusion with host cell membrane" EXACT [] synonym: "viral envelope fusion with host membrane" EXACT [] synonym: "viral envelope fusion with host plasma membrane" EXACT [] synonym: "viral penetration via membrane fusion" BROAD [] synonym: "viral-cell fusion molecule activity" RELATED [] xref: VZ:987 "Fusion of virus membrane with host cell membrane" is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell [Term] id: GO:0019065 name: receptor-mediated endocytosis of virus by host cell namespace: biological_process def: "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:bf, GOC:jl, ISBN:0781702534] synonym: "receptor mediated endocytosis by host of virus particle" EXACT [] synonym: "receptor mediated endocytosis of virus by host" EXACT [] synonym: "receptor mediated endocytosis of virus particle by host" EXACT [] synonym: "receptor-mediated endocytosis of virus by host" EXACT [] synonym: "viral entry into host cell via receptor-mediated endocytosis" RELATED [GOC:bf, GOC:jl] synonym: "viral receptor mediated endocytosis" EXACT [] synonym: "virus receptor-mediated endocytosis by host" EXACT [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0075509 ! endocytosis involved in viral entry into host cell intersection_of: GO:0006898 ! receptor-mediated endocytosis intersection_of: part_of GO:0046718 ! viral entry into host cell [Term] id: GO:0019066 name: obsolete translocation of virus into host cell namespace: biological_process def: "OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534] comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. synonym: "translocation of virus into host cell" EXACT [] synonym: "viral translocation" EXACT [] is_obsolete: true replaced_by: GO:0046718 [Term] id: GO:0019068 name: virion assembly namespace: biological_process alt_id: GO:0042963 def: "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336] synonym: "bacteriophage assembly" NARROW [GOC:bm] synonym: "phage assembly" NARROW [GOC:bm] synonym: "viral assembly" EXACT [] synonym: "viral particle assembly" EXACT [] synonym: "virion assembly and maintenance" EXACT [GOC:bf, GOC:jl] synonym: "virion organization" EXACT [GOC:bf, GOC:jl] synonym: "virus assembly" EXACT [GOC:dph, GOC:tb] synonym: "virus particle assembly" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019069 name: viral capsid assembly namespace: biological_process def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, UniProtKB-KW:KW-0118] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019070 name: viral genome maturation namespace: biological_process def: "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes." [GOC:pk, PMID:21490093] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019071 name: viral DNA cleavage involved in viral genome maturation namespace: biological_process def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0019070 ! viral genome maturation [Term] id: GO:0019072 name: viral genome packaging namespace: biological_process def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019073 name: viral DNA genome packaging namespace: biological_process def: "The packing of viral DNA into a capsid." [ISBN:0781702534] is_a: GO:0019072 ! viral genome packaging [Term] id: GO:0019074 name: viral RNA genome packaging namespace: biological_process def: "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid." [ISBN:0781718325] is_a: GO:0019072 ! viral genome packaging [Term] id: GO:0019075 name: virus maturation namespace: biological_process def: "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release." [ISBN:0781718325] synonym: "bacteriophage maturation" NARROW [PMID:22308333] synonym: "viral maturation" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019076 name: viral release from host cell namespace: biological_process def: "The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl] synonym: "release of virus from host" EXACT [] synonym: "viral exit" EXACT [] synonym: "viral release" EXACT [] synonym: "viral shedding" EXACT [] synonym: "virus exit from host cell" EXACT [GOC:bf, GOC:jl] xref: VZ:1076 "Virus exit from host cell" is_a: GO:0016032 ! viral process is_a: GO:0035891 ! exit from host cell relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019078 name: obsolete lytic viral budding namespace: biological_process def: "OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534] comment: This term was made obsolete because it does not appear to correspond to a real biological process. synonym: "lytic viral budding" EXACT [] is_obsolete: true [Term] id: GO:0019079 name: viral genome replication namespace: biological_process def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] synonym: "sigma virus replication" NARROW [] synonym: "viral replication" BROAD [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019080 name: viral gene expression namespace: biological_process def: "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation." [GOC:bf, GOC:jl, ISBN:0121585336] synonym: "viral genome expression" EXACT [GOC:jl] is_a: GO:0016032 ! viral process [Term] id: GO:0019081 name: viral translation namespace: biological_process def: "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534] synonym: "viral protein anabolism" EXACT [] synonym: "viral protein biosynthesis" EXACT [] synonym: "viral protein biosynthetic process" EXACT [ISBN:0781702534] synonym: "viral protein formation" EXACT [] synonym: "viral protein synthesis" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019082 name: viral protein processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein." [GOC:bf, GOC:jl, ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019083 name: viral transcription namespace: biological_process def: "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell." [GOC:jl, ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019084 name: middle viral transcription namespace: biological_process def: "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication." [GOC:bf, GOC:jl] synonym: "(delayed) early viral mRNA transcription" RELATED [GOC:jh2] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019085 name: early viral transcription namespace: biological_process def: "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." [GOC:bf, GOC:jh2, GOC:jl] synonym: "immediate early viral mRNA transcription" RELATED [] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019086 name: late viral transcription namespace: biological_process def: "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins." [GOC:bf, GOC:jh2, GOC:jl] synonym: "late viral mRNA transcription" RELATED [] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019087 name: transformation of host cell by virus namespace: biological_process def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534] synonym: "viral transformation" EXACT [] synonym: "viral transformation of host cell" EXACT [] xref: Wikipedia:Viral_transformation is_a: GO:0019048 ! modulation by virus of host morphology or physiology [Term] id: GO:0019088 name: immortalization of host cell by virus namespace: biological_process def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534, PMID:24373315] synonym: "viral immortalization" EXACT [] is_a: GO:0019087 ! transformation of host cell by virus is_a: GO:0020021 ! immortalization of host cell [Term] id: GO:0019089 name: transmission of virus namespace: biological_process def: "The transfer of virions in order to create new infection." [ISBN:0781702534] synonym: "viral transmission" EXACT [] is_a: GO:0016032 ! viral process is_a: GO:0044007 ! dissemination or transmission of symbiont from host [Term] id: GO:0019090 name: mitochondrial rRNA export from mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai, PMID:28115039] synonym: "export of mitochondrial rRNA" BROAD [] synonym: "mitochondrial rRNA export" EXACT [] synonym: "mitochondrial rRNA export from mitochondria" EXACT [] synonym: "mitochondrial rRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial rRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial rRNA, mitochondrial export" EXACT [] is_a: GO:0051029 ! rRNA transport is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0019091 name: mitochondrial lrRNA export from mitochondrion namespace: biological_process def: "The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] synonym: "export of mitochondrial lrRNA" BROAD [] synonym: "mitochondrial lrRNA export" EXACT [] synonym: "mitochondrial lrRNA export from mitochondria" EXACT [] synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial lrRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019092 name: mitochondrial srRNA export from mitochondrion namespace: biological_process def: "The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] synonym: "export of mitochondrial srRNA" BROAD [] synonym: "mitochondrial srRNA export" EXACT [] synonym: "mitochondrial srRNA export from mitochondria" EXACT [] synonym: "mitochondrial srRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial srRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial srRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019093 name: mitochondrial RNA localization namespace: biological_process def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] synonym: "mtRNA localization" EXACT [] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0019094 name: pole plasm mRNA localization namespace: biological_process alt_id: GO:0048120 def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT [] synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT [] synonym: "oocyte pole plasm mRNA localization" EXACT [] synonym: "pole granule RNA localization" BROAD [] synonym: "pole plasm mRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0019095 name: pole plasm mitochondrial rRNA localization namespace: biological_process alt_id: GO:0048117 def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT [] synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0019093 ! mitochondrial RNA localization [Term] id: GO:0019096 name: pole plasm mitochondrial lrRNA localization namespace: biological_process alt_id: GO:0048118 def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT [] synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019097 name: pole plasm mitochondrial srRNA localization namespace: biological_process alt_id: GO:0048119 def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT [] synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process alt_id: GO:0033057 alt_id: GO:0044704 def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] subset: goslim_drosophila synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0000003 ! reproduction created_by: janelomax creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019099 name: female germ-line sex determination namespace: biological_process alt_id: GO:0007544 def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] synonym: "sex determination, female germ-line determination" EXACT [] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019100 name: male germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019101 name: female somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019102 name: male somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019103 name: pyrimidine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0019104 name: DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0008578 def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] synonym: "DNA glycosylase activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] xref: EC:3.2.2 xref: Reactome:R-HSA-110218 "Cleavage of uracil by TDG glycosylase" xref: Reactome:R-HSA-110219 "Cleavage of thymine by TDG glycosylase" xref: Reactome:R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase" xref: Reactome:R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase" xref: Reactome:R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase" xref: Reactome:R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH" xref: Reactome:R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase" xref: Reactome:R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase" xref: Reactome:R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase" xref: Reactome:R-HSA-5220959 "TDG excises 5-formylcytosine" xref: Reactome:R-HSA-5221061 "TDG excises 5-carboxylcytosine" xref: Reactome:R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA" xref: Reactome:R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA" xref: Reactome:R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA" xref: Reactome:R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA" xref: Reactome:R-HSA-9629149 "NEIL1 cleaves thymine glycol from damaged DNA" xref: Reactome:R-HSA-9629216 "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA" xref: Reactome:R-HSA-9629470 "NEIL3 cleaves 5-guanidinohydantoin" xref: Reactome:R-HSA-9629483 "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA" xref: Reactome:R-HSA-9629492 "NEIL3 cleaves spiroiminodihydantoin" xref: Reactome:R-HSA-9629497 "NEIL3 cleaves thymine glycol from telomeric DNA" xref: Reactome:R-HSA-9629499 "NEIL3 cleaves thymine glycol" xref: Reactome:R-HSA-9635996 "NEIL3 resolves psoralen-induced ICLs" xref: Reactome:R-HSA-9636008 "NEIL3 resolves abasic site-induced ICLs" is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0019105 name: N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019107 name: myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] xref: Reactome:R-HSA-141367 "Myristoylation of tBID by NMT1" xref: Reactome:R-HSA-162914 "Myristoylation of Nef" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0019108 name: aryl-aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] xref: EC:1.2.1.29 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0394 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0019111 name: phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] synonym: "phenanthrol sulphotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0019112 name: phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0019113 name: limonene monooxygenase activity namespace: molecular_function def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah] xref: EC:1.14.13 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019114 name: catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN] xref: EC:1.13.11 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019115 name: benzaldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] xref: EC:1.2.1 is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0019116 name: hydroxy-nicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, http://umbbd.ahc.umn.edu/] xref: EC:1.5.3.6 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0019117 name: dihydroxyfluorene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422] xref: EC:1.13.11 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019118 name: phenanthrene-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] xref: EC:3.3.2 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0019119 name: phenanthrene-9,10-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0019120 name: hydrolase activity, acting on acid halide bonds, in C-halide compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732] xref: EC:3.8.1 xref: Reactome:R-HSA-9011595 "GSTZ1 dimer dehalogenates DCA to glyoxylate" is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds [Term] id: GO:0019121 name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine namespace: biological_process def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218] xref: RESID:AA0218 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019122 name: peptidyl-D-alanine racemization namespace: biological_process def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191] comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. synonym: "alanine racemization" BROAD [] xref: RESID:AA0191 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0019123 name: peptidyl-methionine racemization namespace: biological_process alt_id: GO:0018087 alt_id: GO:0018369 def: "The racemization of peptidyl-methionine." [RESID:AA0193] xref: RESID:AA0193 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019124 name: peptidyl-isoleucine racemization namespace: biological_process alt_id: GO:0018088 alt_id: GO:0018370 def: "The racemization of peptidyl-isoleucine." [RESID:AA0192] xref: RESID:AA0192 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019125 name: peptidyl-phenylalanine racemization namespace: biological_process alt_id: GO:0018089 alt_id: GO:0018371 def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194] xref: RESID:AA0194 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019126 name: peptidyl-serine racemization namespace: biological_process alt_id: GO:0018090 alt_id: GO:0018372 def: "The racemization of peptidyl-serine." [RESID:AA0195] xref: RESID:AA0195 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019128 name: peptidyl-tryptophan racemization namespace: biological_process alt_id: GO:0018092 alt_id: GO:0018374 def: "The racemization of peptidyl-tryptophan." [RESID:AA0198] xref: RESID:AA0198 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019129 name: peptidyl-leucine racemization namespace: biological_process alt_id: GO:0018093 alt_id: GO:0018375 def: "The racemization of peptidyl-leucine." [RESID:AA0197] xref: RESID:AA0197 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019131 name: obsolete tripeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] comment: This term was made obsolete because it represents a gene product. synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl-peptidase I activity" EXACT [] xref: EC:3.4.14.9 xref: MetaCyc:3.4.14.9-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0019132 name: obsolete C-terminal processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102] comment: This term was made obsolete because it represents a gene product. synonym: "C-terminal processing peptidase activity" EXACT [] synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102] synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] synonym: "protease Re" RELATED [EC:3.4.21.102] synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] synonym: "Tsp protease" NARROW [EC:3.4.21.102] xref: EC:3.4.21.102 xref: MetaCyc:3.4.21.102-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0019133 name: choline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] xref: EC:1.14.15.7 xref: MetaCyc:RXN1F-357 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019134 name: glucosamine-1-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13725] synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] xref: EC:2.3.1.157 xref: KEGG_REACTION:R05332 xref: MetaCyc:2.3.1.157-RXN xref: RHEA:13725 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0019135 name: deoxyhypusine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29] synonym: "deoxyhypusine hydroxylase activity" EXACT [] synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29] synonym: "DOHH activity" EXACT [EC:1.14.99.29] xref: EC:1.14.99.29 xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN xref: Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0019136 name: deoxynucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145] synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145] synonym: "Dm-dNK" RELATED [EC:2.7.1.145] synonym: "ms-dNK" RELATED [EC:2.7.1.145] synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] xref: EC:2.7.1.145 xref: MetaCyc:2.7.1.145-RXN is_a: GO:0019206 ! nucleoside kinase activity relationship: part_of GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process [Term] id: GO:0019137 name: thioglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] synonym: "myrosinase activity" EXACT [] synonym: "sinigrase activity" EXACT [] synonym: "sinigrinase activity" EXACT [] synonym: "thioglucoside glucohydrolase activity" EXACT [] xref: EC:3.2.1.147 xref: MetaCyc:RXN-9946 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019139 name: cytokinin dehydrogenase activity namespace: molecular_function alt_id: GO:0046420 def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "cytokinin oxidase activity" RELATED [] synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] xref: EC:1.5.99.12 xref: MetaCyc:1.5.99.12-RXN xref: MetaCyc:PWY-2841 xref: RHEA:13625 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0019140 name: inositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64] synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64] synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "myo-inositol 3-kinase activity" EXACT [] synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] xref: EC:2.7.1.64 xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN xref: RHEA:21804 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019141 name: 2-dehydropantolactone reductase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214] synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] xref: EC:1.1.1.214 xref: MetaCyc:DEHYDROPANTLACRED-RXN is_a: GO:0036441 ! 2-dehydropantolactone reductase activity [Term] id: GO:0019142 name: 2-hydroxyglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)." [EC:2.3.3.11, RHEA:19185] comment: Note that this function was formerly EC:4.1.3.9. synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11] synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11] xref: EC:2.3.3.11 xref: KEGG_REACTION:R00932 xref: MetaCyc:HYDGLUTSYN-RXN xref: RHEA:19185 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0019143 name: 3-deoxy-manno-octulosonate-8-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11500] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45] xref: EC:3.1.3.45 xref: KEGG_REACTION:R03350 xref: MetaCyc:KDO-8PPHOSPHAT-RXN xref: RHEA:11500 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019144 name: ADP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21] synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw] xref: EC:3.6.1.21 xref: MetaCyc:ADPSUGPPHOSPHAT-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019145 name: aminobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19] xref: EC:1.2.1.19 xref: MetaCyc:AMINOBUTDEHYDROG-RXN xref: RHEA:19105 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0019146 name: arabinose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+)." [EC:5.3.1.13, RHEA:23104] synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13] synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13] xref: EC:5.3.1.13 xref: KEGG_REACTION:R01530 xref: MetaCyc:DARAB5PISOM-RXN xref: RHEA:23104 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0019147 name: (R)-aminopropanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH." [EC:1.1.1.75, RHEA:16517] synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L-aminopropanol dehydrogenase activity" EXACT [] xref: EC:1.1.1.75 xref: KEGG_REACTION:R03759 xref: MetaCyc:AMINOPROPDEHYDROG-RXN xref: RHEA:16517 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019148 name: D-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15] xref: EC:4.4.1.15 xref: MetaCyc:DCYSDESULF-RXN xref: RHEA:11268 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0019149 name: 3-chloro-D-alanine dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2] synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2] xref: EC:4.5.1.2 xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN xref: RHEA:18873 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019150 name: D-ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47] synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47] xref: EC:2.7.1.47 xref: MetaCyc:D-RIBULOKIN-RXN xref: RHEA:17601 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0019151 name: galactose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose 1-dehydrogenase activity" EXACT [] synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48] synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] xref: EC:1.1.1.48 xref: MetaCyc:GALACTODEHYDROG-RXN xref: RHEA:21296 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019152 name: acetoin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.303, EC:1.1.1.304, MetaCyc:ACETOINDEHYDROG-RXN] synonym: "diacetyl reductase activity" EXACT [] xref: EC:1.1.1.303 xref: EC:1.1.1.304 xref: KEGG_REACTION:R02343 xref: MetaCyc:ACETOINDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019153 name: protein-disulfide reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2] synonym: "glutaredoxin reductase" RELATED [] synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "glutathione-insulin transhydrogenase activity" EXACT [] synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "insulin reductase activity" EXACT [EC:1.8.4.2] synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2] synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2] synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] xref: EC:1.8.4.2 xref: MetaCyc:PRODISULFREDUCT-RXN xref: RHEA:21064 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0019154 name: glycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21264] synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14] xref: EC:1.1.99.14 xref: KEGG_REACTION:R00476 xref: MetaCyc:GLYCOLATEDEHYDRO-RXN xref: RHEA:21264 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0019155 name: 3-(imidazol-5-yl)lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111] synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111] xref: EC:1.1.1.111 xref: MetaCyc:IMILACTDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019156 name: isoamylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68] xref: EC:3.2.1.68 xref: MetaCyc:3.2.1.68-RXN xref: MetaCyc:RXN-12280 xref: MetaCyc:RXN-14380 is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019157 name: malate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate." [RHEA:10515] synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [] synonym: "FAD-dependent malate oxidase activity" EXACT [] synonym: "malic dehydrogenase II" RELATED [] synonym: "malic oxidase activity" EXACT [] xref: KEGG_REACTION:R00360 xref: MetaCyc:MALOX-RXN xref: RHEA:10515 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0019158 name: mannokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7] synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7] synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7] xref: EC:2.7.1.7 xref: MetaCyc:MANNKIN-RXN xref: RHEA:11028 is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0019159 name: nicotinamide-nucleotide amidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "NMN amidohydrolase" NARROW [] synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42] xref: EC:3.5.1.42 xref: MetaCyc:NMNAMIDOHYDRO-RXN xref: RHEA:12400 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019160 name: NMN nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide." [EC:3.2.2.14, RHEA:23140] synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMNase activity" EXACT [EC:3.2.2.14] synonym: "NMNGhase activity" EXACT [EC:3.2.2.14] xref: EC:3.2.2.14 xref: KEGG_REACTION:R01270 xref: MetaCyc:NMNNUCLEOSID-RXN xref: RHEA:23140 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0019161 name: diamine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] synonym: "amine transaminase activity" EXACT [EC:2.6.1.29] synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine aminotransferase activity" EXACT [] synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] xref: EC:2.6.1.29 xref: MetaCyc:DIAMTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019162 name: pyridoxamine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10844] synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] xref: EC:2.6.1.31 xref: KEGG_REACTION:R01713 xref: MetaCyc:PYROXALTRANSAM-RXN xref: RHEA:10844 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019163 name: pyridoxamine-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] xref: EC:2.6.1.54 xref: MetaCyc:PYRDAMPTRANS-RXN xref: RHEA:15877 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019164 name: pyruvate synthase activity namespace: molecular_function alt_id: GO:0018696 def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG_REACTION:R01196] synonym: "PFOR" EXACT [] synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate-ferredoxin reductase activity" EXACT [] synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1] synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] xref: EC:1.2.7.1 xref: KEGG_REACTION:R01196 xref: MetaCyc:PYRUFLAVREDUCT-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0019165 name: thiamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate." [EC:2.7.1.89, RHEA:12012] synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89] synonym: "thiamin kinase activity" EXACT [EC:2.7.1.89] synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89] xref: EC:2.7.1.89 xref: KEGG_REACTION:R02134 xref: MetaCyc:THIKIN-RXN xref: RHEA:12012 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019166 name: trans-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38] synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38] synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38] xref: EC:1.3.1.38 xref: MetaCyc:TRANSENOYLCOARED-RXN xref: Reactome:R-HSA-6786720 "DECR2 reduces LCtE-CoA to t3enoyl-CoA" xref: Reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA" xref: Reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0019168 name: 2-octaprenylphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019170 name: methylglyoxal reductase (NADH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78] synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] synonym: "methylglyoxal reductase activity" EXACT [] xref: EC:1.1.1.78 xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24528 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019171 name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]." [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN] synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.59 xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN xref: RHEA:13097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0019172 name: glyoxalase III activity namespace: molecular_function def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27754] comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase). synonym: "(R)-lactate hydro-lyase" EXACT [] synonym: "D-lactate dehydratase" EXACT [] synonym: "glutathione-independent glyoxalase activity" RELATED [] xref: MetaCyc:GLYOXIII-RXN xref: RHEA:27754 is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0019249 ! lactate biosynthetic process relationship: part_of GO:0061727 ! methylglyoxal catabolic process to lactate [Term] id: GO:0019174 name: tetrahydrothiophene 1-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] xref: MetaCyc:THTOREDUCT-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019176 name: dihydroneopterin monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0019177 name: dihydroneopterin triphosphate pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019178 name: NADP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] xref: MetaCyc:NADPPHOSPHAT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019179 name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33] xref: EC:2.6.1.33 xref: MetaCyc:2.6.1.33-RXN xref: RHEA:19085 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019180 name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10368] synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59] synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] xref: EC:2.6.1.59 xref: KEGG_REACTION:R04438 xref: MetaCyc:2.6.1.59-RXN xref: RHEA:10368 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019181 name: halohydrin hydrogen-halide-lyase activity namespace: molecular_function def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917] is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019182 name: histamine-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022835 ! transmitter-gated channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0019183 name: histamine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0098878 ! neurotransmitter receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0019184 name: nonribosomal peptide biosynthetic process namespace: biological_process def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732] synonym: "non-ribosomal peptide biosynthesis" EXACT [] synonym: "non-ribosomal peptide biosynthetic process" EXACT [] synonym: "non-ribosomal peptide formation" EXACT [] synonym: "non-ribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide anabolism" EXACT [] synonym: "nonribosomal peptide biosynthesis" EXACT [] synonym: "nonribosomal peptide formation" EXACT [] synonym: "nonribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] xref: MIPS_funcat:01.20.36 is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0019185 name: snRNA-activating protein complex namespace: cellular_component def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] synonym: "SNAPc" EXACT [] is_a: GO:0044798 ! nuclear transcription factor complex [Term] id: GO:0019186 name: acyl-CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019187 name: beta-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646] is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0019191 name: cellobiose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019190 def: "Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cellobiose permease activity" EXACT [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0019533 ! cellobiose transport [Term] id: GO:0019194 name: sorbose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019193 def: "Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose porter activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0019196 name: galactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0019195 def: "Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "galactosamine porter activity" EXACT [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0019197 name: phosphoenolpyruvate-dependent sugar phosphotransferase complex namespace: cellular_component def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0019198 name: transmembrane receptor protein phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd] xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019199 name: transmembrane receptor protein kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] xref: Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex" xref: Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated" is_a: GO:0004672 ! protein kinase activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019200 name: carbohydrate kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] xref: Reactome:R-HSA-8931653 "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1" is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0019202 name: amino acid kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] is_a: GO:0016301 ! kinase activity [Term] id: GO:0019203 name: carbohydrate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] xref: Reactome:R-HSA-3781011 "EPM2A dimer dephosphorylates phosphoglycogen-GYG2" xref: Reactome:R-HSA-3781018 "EPM2A dimer dephosphorylates phosphoglycogen-GYG1" xref: Reactome:R-HSA-3791349 "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019204 name: obsolete nucleotide phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] comment: This term was defined to cover phosphatase activity against polynucleotides, but had subclasses and annotations for phosphatase activity against free nucleotides. It has therefore been split. Use GO:0098519 (nucleotide phosphatase activity, acting against free nucleotides) or GO:0098518 (polynucleotide phosphatase activity). synonym: "nucleotide phosphatase activity" EXACT [] is_obsolete: true consider: GO:0098518 consider: GO:0098519 [Term] id: GO:0019205 name: nucleobase-containing compound kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0016301 ! kinase activity [Term] id: GO:0019206 name: nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] xref: Reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)" xref: Reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]" xref: Reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]" xref: Reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP" xref: Reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs" xref: Reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)" xref: Reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]" xref: Reactome:R-HSA-73632 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]" xref: Reactome:R-HSA-74207 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)" is_a: GO:0019205 ! nucleobase-containing compound kinase activity relationship: part_of GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0019207 name: kinase regulator activity namespace: molecular_function def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0043549 ! regulation of kinase activity [Term] id: GO:0019208 name: phosphatase regulator activity namespace: molecular_function def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0019902 ! phosphatase binding relationship: regulates GO:0016791 ! phosphatase activity [Term] id: GO:0019209 name: kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] xref: MIPS_funcat:18.02.01.01.05 is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019207 ! kinase regulator activity relationship: part_of GO:0033674 ! positive regulation of kinase activity [Term] id: GO:0019210 name: kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] xref: MIPS_funcat:18.02.01.02.05 is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019207 ! kinase regulator activity relationship: part_of GO:0033673 ! negative regulation of kinase activity [Term] id: GO:0019211 name: phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019212 name: phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019213 name: deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] subset: goslim_pir xref: Reactome:R-HSA-5689000 "AADAC deacetylates PHEN" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019214 name: obsolete surfactant activity namespace: molecular_function def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it represents involvement in a process. synonym: "surfactant activity" EXACT [] is_obsolete: true consider: GO:0050828 [Term] id: GO:0019215 name: intermediate filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] xref: MIPS_funcat:01.06.10 is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006629 ! lipid metabolic process relationship: regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0019217 name: regulation of fatty acid metabolic process namespace: biological_process alt_id: GO:0006632 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "regulation of fatty acid metabolism" EXACT [] xref: MIPS_funcat:01.06.10 is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006631 ! fatty acid metabolic process relationship: regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008202 ! steroid metabolic process relationship: regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0019221 name: cytokine-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "cytokine mediated signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: part_of GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] synonym: "conduction of nerve impulse" EXACT [GOC:dph] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0035637 ! multicellular organismal signaling is_a: GO:0050877 ! nervous system process relationship: has_part GO:0001508 ! action potential relationship: has_part GO:0007268 ! chemical synaptic transmission relationship: part_of GO:0007154 ! cell communication [Term] id: GO:0019227 name: neuronal action potential propagation namespace: biological_process def: "The propagation of an action potential along an axon, away from the soma." [GOC:isa_complete] xref: MIPS_funcat:34.03.03 is_a: GO:0050877 ! nervous system process is_a: GO:0098870 ! action potential propagation relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019228 name: neuronal action potential namespace: biological_process def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] xref: MIPS_funcat:34.03.03 is_a: GO:0001508 ! action potential relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019229 name: regulation of vasoconstriction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] is_a: GO:0097746 ! regulation of blood vessel diameter is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042310 ! vasoconstriction relationship: regulates GO:0042310 ! vasoconstriction [Term] id: GO:0019230 name: proprioception namespace: biological_process def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [ISBN:072168677X] xref: MIPS_funcat:36.25.01.09 xref: Wikipedia:Proprioception is_a: GO:0007600 ! sensory perception relationship: part_of GO:0050884 ! neuromuscular process controlling posture [Term] id: GO:0019231 name: perception of static position namespace: biological_process def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X] is_a: GO:0019230 ! proprioception [Term] id: GO:0019232 name: perception of rate of movement namespace: biological_process def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah] synonym: "kinesthesia" EXACT [] is_a: GO:0019230 ! proprioception [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators] synonym: "nociception" EXACT [] synonym: "perception of physiological pain" NARROW [] xref: MIPS_funcat:36.25.01.15 xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception [Term] id: GO:0019234 name: sensory perception of fast pain namespace: biological_process def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019235 name: sensory perception of slow pain namespace: biological_process def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019236 name: response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] synonym: "pheromone response" EXACT [] xref: MIPS_funcat:34.11.03.07 is_a: GO:0010033 ! response to organic substance [Term] id: GO:0019237 name: centromeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577] synonym: "centromere binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0019238 name: cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah] is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0019239 name: deaminase activity namespace: molecular_function def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] subset: goslim_pir xref: Reactome:R-HSA-9014641 "HRSP12 deaminates 2AA to 2OBUTA" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019240 name: citrulline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline anabolism" EXACT [] synonym: "citrulline biosynthesis" EXACT [] synonym: "citrulline formation" EXACT [] synonym: "citrulline synthesis" EXACT [] xref: MetaCyc:CITRULBIO-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019241 name: citrulline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline breakdown" EXACT [] synonym: "citrulline catabolism" EXACT [] synonym: "citrulline degradation" EXACT [] xref: MetaCyc:CITRULLINE-DEG-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019242 name: methylglyoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] synonym: "methylglyoxal anabolism" EXACT [] synonym: "methylglyoxal biosynthesis" EXACT [] synonym: "methylglyoxal formation" EXACT [] synonym: "methylglyoxal synthesis" EXACT [] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0019243 name: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020] synonym: "D-lactate biosynthesis from methylglyoxal" BROAD [] synonym: "D-lactate biosynthetic process from methylglyoxal" BROAD [] synonym: "glyoxalase system" RELATED [] synonym: "methylglyoxal breakdown to D-lactate" BROAD [] synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT [] synonym: "methylglyoxal degradation to D-lactate" BROAD [] synonym: "methylglyoxal detoxification" RELATED [] xref: MetaCyc:PWY-5386 is_a: GO:0061727 ! methylglyoxal catabolic process to lactate [Term] id: GO:0019244 name: lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "lactate anabolism from pyruvate" EXACT [] synonym: "lactate formation from pyruvate" EXACT [] synonym: "lactate synthesis from pyruvate" EXACT [] synonym: "pyruvate fermentation to lactate" EXACT [] xref: Reactome:R-HSA-71849.1 is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019249 ! lactate biosynthetic process relationship: has_part GO:0004457 ! lactate dehydrogenase activity [Term] id: GO:0019245 name: D(-)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "D(-)-lactate anabolism from pyruvate" EXACT [] synonym: "D(-)-lactate formation from pyruvate" EXACT [] synonym: "D(-)-lactate synthesis from pyruvate" EXACT [] is_a: GO:0019244 ! lactate biosynthetic process from pyruvate relationship: has_part GO:0008720 ! D-lactate dehydrogenase activity [Term] id: GO:0019246 name: L(+)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "L(+)-lactate anabolism from pyruvate" EXACT [] synonym: "L(+)-lactate formation from pyruvate" EXACT [] synonym: "L(+)-lactate synthesis from pyruvate" EXACT [] synonym: "S-lactate biosynthetic process from pyruvate" EXACT [] xref: MetaCyc:PWY-5481 is_a: GO:0019244 ! lactate biosynthetic process from pyruvate relationship: has_part GO:0004459 ! L-lactate dehydrogenase activity [Term] id: GO:0019247 name: lactate racemization namespace: biological_process def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538] is_a: GO:0006089 ! lactate metabolic process [Term] id: GO:0019248 name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY] synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT [] xref: MetaCyc:MGLDLCTANA-PWY is_a: GO:0019249 ! lactate biosynthetic process is_a: GO:0061727 ! methylglyoxal catabolic process to lactate [Term] id: GO:0019249 name: lactate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] synonym: "lactate anabolism" EXACT [] synonym: "lactate biosynthesis" EXACT [] synonym: "lactate formation" EXACT [] synonym: "lactate synthesis" EXACT [] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0019250 name: aerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators] synonym: "aerobic cobalamin anabolism" EXACT [] synonym: "aerobic cobalamin biosynthesis" EXACT [] synonym: "aerobic cobalamin formation" EXACT [] synonym: "aerobic cobalamin synthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, aerobic" EXACT [] synonym: "cobalamin biosynthetic process, aerobic" EXACT [] synonym: "vitamin B12 biosynthesis, aerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, aerobic" EXACT [] xref: MetaCyc:P381-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019251 name: anaerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators] synonym: "anaerobic cobalamin anabolism" EXACT [] synonym: "anaerobic cobalamin biosynthesis" EXACT [] synonym: "anaerobic cobalamin formation" EXACT [] synonym: "anaerobic cobalamin synthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, anaerobic" EXACT [] synonym: "cobalamin biosynthetic process, anaerobic" EXACT [] synonym: "vitamin B12 biosynthesis, anaerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT [] xref: MetaCyc:COBALSYN-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019252 name: starch biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch anabolism" EXACT [] synonym: "starch biosynthesis" EXACT [] synonym: "starch formation" EXACT [] synonym: "starch synthesis" EXACT [] xref: MetaCyc:PWY-622 xref: MIPS_funcat:01.05.01.03.02.04 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0019253 name: reductive pentose-phosphate cycle namespace: biological_process def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "C3 photosynthesis" NARROW [] synonym: "Calvin cycle" NARROW [] xref: MetaCyc:CALVIN-PWY xref: MIPS_funcat:01.05.01.05.01 is_a: GO:0019685 ! photosynthesis, dark reaction relationship: part_of GO:0015977 ! carbon fixation [Term] id: GO:0019254 name: carnitine metabolic process, CoA-linked namespace: biological_process def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] synonym: "carnitine metabolism, CoA-linked" EXACT [] xref: MetaCyc:CARNMET-PWY is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0019255 name: glucose 1-phosphate metabolic process namespace: biological_process alt_id: GO:0006008 def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] synonym: "glucose 1-phosphate metabolism" EXACT [] synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah] xref: MetaCyc:GLUCOSE1PMETAB-PWY is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019256 name: acrylonitrile catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai] synonym: "acrylonitrile breakdown" EXACT [] synonym: "acrylonitrile catabolism" EXACT [] synonym: "acrylonitrile degradation" EXACT [] xref: MetaCyc:P344-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018865 ! acrylonitrile metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0050899 ! nitrile catabolic process [Term] id: GO:0019257 name: 4-nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai] synonym: "4-nitrotoluene metabolism" EXACT [] synonym: "4NT metabolic process" EXACT [] synonym: "4NT metabolism" EXACT [] is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0019258 name: 4-nitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] synonym: "4-nitrotoluene breakdown" EXACT [] synonym: "4-nitrotoluene catabolism" EXACT [] synonym: "4-nitrotoluene degradation" EXACT [] synonym: "4NT catabolic process" EXACT [] synonym: "4NT catabolism" EXACT [] xref: MetaCyc:P421-PWY is_a: GO:0019257 ! 4-nitrotoluene metabolic process is_a: GO:0046263 ! nitrotoluene catabolic process [Term] id: GO:0019260 name: 1,2-dichloroethane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators] synonym: "1,2-dichloroethane breakdown" EXACT [] synonym: "1,2-dichloroethane catabolism" EXACT [] synonym: "1,2-dichloroethane degradation" EXACT [] xref: MetaCyc:12DICHLORETHDEG-PWY is_a: GO:0018899 ! 1,2-dichloroethane metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019261 name: 1,4-dichlorobenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai] synonym: "1,4-dichlorobenzene breakdown" EXACT [] synonym: "1,4-dichlorobenzene catabolism" EXACT [] synonym: "1,4-dichlorobenzene degradation" EXACT [] xref: MetaCyc:14DICHLORBENZDEG-PWY is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019262 name: N-acetylneuraminate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] synonym: "N-acetylneuraminate breakdown" EXACT [] synonym: "N-acetylneuraminate catabolism" EXACT [] synonym: "N-acetylneuraminate degradation" EXACT [] xref: MetaCyc:P441-PWY is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019263 name: adamantanone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] synonym: "adamantanone breakdown" EXACT [] synonym: "adamantanone catabolism" EXACT [] synonym: "adamantanone degradation" EXACT [] xref: MetaCyc:P481-PWY is_a: GO:0018866 ! adamantanone metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019264 name: glycine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators] synonym: "glycine anabolism from serine" EXACT [] synonym: "glycine formation from serine" EXACT [] synonym: "glycine synthesis from serine" EXACT [] xref: MetaCyc:GLYSYN-PWY is_a: GO:0006545 ! glycine biosynthetic process is_a: GO:0006563 ! L-serine metabolic process [Term] id: GO:0019265 name: glycine biosynthetic process, by transamination of glyoxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators] synonym: "glycine anabolism, by transamination of glyoxylate" EXACT [] synonym: "glycine formation, by transamination of glyoxylate" EXACT [] synonym: "glycine synthesis, by transamination of glyoxylate" EXACT [] is_a: GO:0006545 ! glycine biosynthetic process [Term] id: GO:0019266 name: asparagine biosynthetic process from oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators] synonym: "asparagine anabolism from oxaloacetate" EXACT [] synonym: "asparagine formation from oxaloacetate" EXACT [] synonym: "asparagine synthesis from oxaloacetate" EXACT [] xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019267 name: asparagine biosynthetic process from cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators] synonym: "asparagine anabolism from cysteine" EXACT [] synonym: "asparagine formation from cysteine" EXACT [] synonym: "asparagine synthesis from cysteine" EXACT [] xref: MetaCyc:ASPSYNII-PWY is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0019268 name: obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function. synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT [] is_obsolete: true consider: GO:0004353 consider: GO:0006537 [Term] id: GO:0019269 name: obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators] comment: This term was made obsolete because it refers to a molecular function. synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT [] is_obsolete: true consider: GO:0004355 consider: GO:0006537 [Term] id: GO:0019270 name: aerobactin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] synonym: "aerobactin anabolism" EXACT [] synonym: "aerobactin biosynthesis" EXACT [] synonym: "aerobactin formation" EXACT [] synonym: "aerobactin synthesis" EXACT [] xref: MetaCyc:AEROBACTINSYN-PWY is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046442 ! aerobactin metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process [Term] id: GO:0019271 name: aerobactin transport namespace: biological_process def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658] is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0019272 name: L-alanine biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators] synonym: "L-alanine anabolism from pyruvate" EXACT [] synonym: "L-alanine formation from pyruvate" EXACT [] synonym: "L-alanine synthesis from pyruvate" EXACT [] xref: MetaCyc:ALANINE-SYN2-PWY xref: MetaCyc:ALANINE-VALINESYN-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019273 name: L-alanine biosynthetic process via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators] synonym: "L-alanine anabolism via ornithine" EXACT [] synonym: "L-alanine formation via ornithine" EXACT [] synonym: "L-alanine synthesis via ornithine" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019276 name: UDP-N-acetylgalactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019277 name: UDP-N-acetylgalactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine anabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylgalactosamine formation" EXACT [] synonym: "UDP-N-acetylgalactosamine synthesis" EXACT [] xref: MetaCyc:UDPNACETYLGALSYN-PWY is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0019278 name: UDP-N-acetylgalactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine breakdown" EXACT [] synonym: "UDP-N-acetylgalactosamine catabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine degradation" EXACT [] is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0019279 name: L-methionine biosynthetic process from L-homoserine via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah] xref: MetaCyc:HOMOSER-METSYN-PWY is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019280 name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:HSERMETANA-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019281 name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:MET-SAM-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019283 name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019284 name: L-methionine salvage from S-adenosylmethionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine." [GOC:go_curators, GOC:vw] synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah] is_a: GO:0071267 ! L-methionine salvage relationship: part_of GO:0033353 ! S-adenosylmethionine cycle [Term] id: GO:0019285 name: glycine betaine biosynthetic process from choline namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl] synonym: "choline oxidation" EXACT [GOC:dph, PMID:23563483] synonym: "glycine betaine anabolism from choline" EXACT [] synonym: "glycine betaine formation from choline" EXACT [] synonym: "glycine betaine synthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthetic process from choline" EXACT [] xref: MetaCyc:BETSYN-PWY xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY xref: MetaCyc:P542-PWY is_a: GO:0019695 ! choline metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019286 name: glycine betaine biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators] synonym: "glycine betaine anabolism from glycine" EXACT [] synonym: "glycine betaine formation from glycine" EXACT [] synonym: "glycine betaine synthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT [] xref: MetaCyc:P541-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019287 name: isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922] synonym: "Ac-MVA pathway" EXACT [PMID:14517367] synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367] synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr] synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process [Term] id: GO:0019288 name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055] synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:pr] synonym: "isopentenyl diphosphate biosynthetic process, MEP pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT [] synonym: "non-MVA pathway" EXACT [] xref: MetaCyc:NONMEVIPP-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process [Term] id: GO:0019289 name: rhizobactin 1021 biosynthetic process namespace: biological_process alt_id: GO:0031193 alt_id: GO:0031194 def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] synonym: "rhizobactin 1021 anabolism" EXACT [] synonym: "rhizobactin 1021 biosynthesis" EXACT [] synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW [] synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW [] synonym: "rhizobactin 1021 formation" EXACT [] synonym: "rhizobactin 1021 synthesis" EXACT [] xref: MetaCyc:PWY-761 is_a: GO:0019540 ! siderophore biosynthetic process from catechol is_a: GO:0046494 ! rhizobactin 1021 metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0019290 name: siderophore biosynthetic process namespace: biological_process alt_id: GO:0031178 alt_id: GO:0031180 def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators] comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'. synonym: "siderochrome biosynthesis" NARROW [] synonym: "siderochrome biosynthetic process" NARROW [] synonym: "siderophore anabolism" EXACT [] synonym: "siderophore biosynthesis" EXACT [] synonym: "siderophore biosynthetic process, peptide formation" NARROW [] synonym: "siderophore biosynthetic process, peptide modification" NARROW [] synonym: "siderophore formation" EXACT [] synonym: "siderophore synthesis" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0019292 name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators] synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT [] xref: MetaCyc:TYRSYN is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0019293 name: tyrosine biosynthetic process, by oxidation of phenylalanine namespace: biological_process alt_id: GO:0019291 def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators] synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0055114 ! oxidation-reduction process relationship: has_part GO:0055114 ! oxidation-reduction process [Term] id: GO:0019294 name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ISBN:0198506732] synonym: "KDO biosynthesis" EXACT [] synonym: "KDO biosynthetic process" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] xref: MetaCyc:KDOSYN-PWY is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0019295 name: coenzyme M biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684] synonym: "coenzyme M anabolism" EXACT [] synonym: "coenzyme M biosynthesis" EXACT [] synonym: "coenzyme M formation" EXACT [] synonym: "coenzyme M synthesis" EXACT [] xref: MetaCyc:P261-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019296 ! coenzyme M metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0019296 name: coenzyme M metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme M metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019297 name: coenzyme B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme B metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019298 name: coenzyme B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051] synonym: "coenzyme B anabolism" EXACT [] synonym: "coenzyme B biosynthesis" EXACT [] synonym: "coenzyme B formation" EXACT [] synonym: "coenzyme B synthesis" EXACT [] xref: MetaCyc:P241-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019297 ! coenzyme B metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0019299 name: rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732] synonym: "rhamnose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019300 name: rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] synonym: "rhamnose anabolism" EXACT [] synonym: "rhamnose biosynthesis" EXACT [] synonym: "rhamnose formation" EXACT [] synonym: "rhamnose synthesis" EXACT [] is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019301 name: rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] synonym: "rhamnose breakdown" EXACT [] synonym: "rhamnose catabolism" EXACT [] synonym: "rhamnose degradation" EXACT [] xref: MetaCyc:RHAMCAT-PWY is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019302 name: D-ribose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732] synonym: "D-ribose anabolism" EXACT [] synonym: "D-ribose biosynthesis" EXACT [] synonym: "D-ribose formation" EXACT [] synonym: "D-ribose synthesis" EXACT [] is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0019303 name: D-ribose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732] synonym: "D-ribose breakdown" EXACT [] synonym: "D-ribose catabolism" EXACT [] synonym: "D-ribose degradation" EXACT [] xref: MetaCyc:RIBOKIN-PWY is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0019304 name: anaerobic rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic rhamnose breakdown" EXACT [] synonym: "anaerobic rhamnose catabolism" EXACT [] synonym: "anaerobic rhamnose degradation" EXACT [] is_a: GO:0019301 ! rhamnose catabolic process [Term] id: GO:0019305 name: dTDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-rhamnose anabolism" EXACT [] synonym: "dTDP-rhamnose biosynthesis" EXACT [] synonym: "dTDP-rhamnose formation" EXACT [] synonym: "dTDP-rhamnose synthesis" EXACT [] xref: MetaCyc:DTDPRHAMSYN-PWY xref: MetaCyc:PWY-3221 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046383 ! dTDP-rhamnose metabolic process [Term] id: GO:0019306 name: GDP-D-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-D-rhamnose anabolism" EXACT [] synonym: "GDP-D-rhamnose biosynthesis" EXACT [] synonym: "GDP-D-rhamnose formation" EXACT [] synonym: "GDP-D-rhamnose synthesis" EXACT [] xref: MetaCyc:GDPRHAMSYN-PWY is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046382 ! GDP-D-rhamnose metabolic process [Term] id: GO:0019307 name: mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] synonym: "mannose anabolism" EXACT [] synonym: "mannose biosynthesis" EXACT [] synonym: "mannose formation" EXACT [] synonym: "mannose synthesis" EXACT [] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019308 name: dTDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-mannose anabolism" EXACT [] synonym: "dTDP-mannose biosynthesis" EXACT [] synonym: "dTDP-mannose formation" EXACT [] synonym: "dTDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046371 ! dTDP-mannose metabolic process [Term] id: GO:0019309 name: mannose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] synonym: "mannose breakdown" EXACT [] synonym: "mannose catabolism" EXACT [] synonym: "mannose degradation" EXACT [] xref: MetaCyc:MANNCAT-PWY is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019310 name: inositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:go_curators] synonym: "inositol breakdown" EXACT [] synonym: "inositol catabolism" EXACT [] synonym: "inositol degradation" EXACT [] synonym: "myo-inositol catabolic process" NARROW [] synonym: "myo-inositol catabolism" NARROW [] synonym: "vitamin Bh catabolic process" EXACT [] synonym: "vitamin Bh catabolism" EXACT [] xref: MetaCyc:P562-PWY is_a: GO:0006020 ! inositol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019311 name: sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] synonym: "sorbose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019312 name: L-sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-sorbose metabolism" EXACT [] xref: MetaCyc:P302-PWY is_a: GO:0019311 ! sorbose metabolic process [Term] id: GO:0019313 name: allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] synonym: "allose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019314 name: D-allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose metabolism" EXACT [] is_a: GO:0019313 ! allose metabolic process [Term] id: GO:0019315 name: D-allose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose anabolism" EXACT [] synonym: "D-allose biosynthesis" EXACT [] synonym: "D-allose formation" EXACT [] synonym: "D-allose synthesis" EXACT [] is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046366 ! allose biosynthetic process [Term] id: GO:0019316 name: D-allose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose breakdown" EXACT [] synonym: "D-allose catabolism" EXACT [] synonym: "D-allose degradation" EXACT [] xref: MetaCyc:PWY0-44 is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046367 ! allose catabolic process [Term] id: GO:0019317 name: fucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl] synonym: "fucose breakdown" EXACT [] synonym: "fucose catabolism" EXACT [] synonym: "fucose degradation" EXACT [] xref: MetaCyc:FUCCAT-PWY is_a: GO:0006004 ! fucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019318 name: hexose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019319 name: hexose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose anabolism" EXACT [] synonym: "hexose biosynthesis" EXACT [] synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019320 name: hexose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose breakdown" EXACT [] synonym: "hexose catabolism" EXACT [] synonym: "hexose degradation" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019321 name: pentose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019322 name: pentose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose anabolism" EXACT [] synonym: "pentose biosynthesis" EXACT [] synonym: "pentose formation" EXACT [] synonym: "pentose synthesis" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019323 name: pentose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose breakdown" EXACT [] synonym: "pentose catabolism" EXACT [] synonym: "pentose degradation" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019324 name: L-lyxose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-lyxose metabolism" EXACT [] xref: MetaCyc:LYXMET-PWY is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019325 name: anaerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic fructose breakdown" EXACT [] synonym: "anaerobic fructose catabolism" EXACT [] synonym: "anaerobic fructose degradation" EXACT [] xref: MetaCyc:ANAEROFRUCAT-PWY is_a: GO:0006001 ! fructose catabolic process is_a: GO:0019317 ! fucose catabolic process [Term] id: GO:0019326 name: nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] synonym: "nitrotoluene metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0019327 name: lead sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY] synonym: "lead sulphide oxidation" EXACT [GOC:mah] synonym: "oxidation of galena" EXACT [] synonym: "oxidation of lead sulfide" EXACT [] xref: MetaCyc:P301-PWY is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019328 name: anaerobic gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl] synonym: "anaerobic gallate breakdown" EXACT [] synonym: "anaerobic gallate catabolism" EXACT [] synonym: "anaerobic gallate degradation" EXACT [] synonym: "anaerobic gallic acid catabolic process" EXACT [] synonym: "anaerobic gallic acid catabolism" EXACT [] synonym: "gallate fermentation" EXACT [] xref: MetaCyc:P3-PWY is_a: GO:0019396 ! gallate catabolic process [Term] id: GO:0019329 name: ammonia oxidation namespace: biological_process def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] xref: MIPS_funcat:01.02.01.05 is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019330 name: aldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [GOC:curators] synonym: "aldoxime metabolism" EXACT [] xref: MetaCyc:P345-PWY is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019331 name: anaerobic respiration, using ammonium as electron donor namespace: biological_process def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY] synonym: "anaerobic ammonium oxidation" BROAD [] synonym: "anammox" EXACT [] xref: MetaCyc:P303-PWY xref: Wikipedia:Anammox is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019332 name: aerobic respiration, using nitrite as electron donor namespace: biological_process def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY] synonym: "nitrite oxidation" BROAD [] xref: MetaCyc:P282-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019333 name: denitrification pathway namespace: biological_process def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY] xref: MetaCyc:DENITRIFICATION-PWY is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0019334 name: p-cymene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai] synonym: "p-cymene breakdown" EXACT [] synonym: "p-cymene catabolism" EXACT [] synonym: "p-cymene degradation" EXACT [] xref: MetaCyc:PWY-741 is_a: GO:0018953 ! p-cymene metabolic process is_a: GO:0043694 ! monoterpene catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0019335 name: 3-methylquinoline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] synonym: "3-methylquinoline breakdown" EXACT [] synonym: "3-methylquinoline catabolism" EXACT [] synonym: "3-methylquinoline degradation" EXACT [] xref: MetaCyc:PWY-721 is_a: GO:0018930 ! 3-methylquinoline metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] synonym: "phenol-containing compound breakdown" EXACT [] synonym: "phenol-containing compound catabolism" EXACT [] synonym: "phenol-containing compound degradation" EXACT [] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019337 name: tetrachloroethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai] synonym: "tetrachloroethene catabolic process" EXACT [] synonym: "tetrachloroethene catabolism" EXACT [] synonym: "tetrachloroethylene breakdown" EXACT [] synonym: "tetrachloroethylene catabolism" EXACT [] synonym: "tetrachloroethylene degradation" EXACT [] xref: MetaCyc:PCEDEG-PWY is_a: GO:0018967 ! tetrachloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019338 name: pentachlorophenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators] synonym: "pentachlorophenol breakdown" EXACT [] synonym: "pentachlorophenol catabolism" EXACT [] synonym: "pentachlorophenol degradation" EXACT [] xref: MetaCyc:PCPDEG-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018961 ! pentachlorophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0019339 name: parathion catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] synonym: "parathion breakdown" EXACT [] synonym: "parathion catabolism" EXACT [] synonym: "parathion degradation" EXACT [] xref: MetaCyc:PARATHION-DEGRADATION-PWY is_a: GO:0018952 ! parathion metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0019340 name: dibenzofuran catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzofuran breakdown" EXACT [] synonym: "dibenzofuran catabolism" EXACT [] synonym: "dibenzofuran degradation" EXACT [] xref: MetaCyc:P662-PWY is_a: GO:0018893 ! dibenzofuran metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019341 name: dibenzo-p-dioxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai] synonym: "dibenzo-p-dioxin breakdown" EXACT [] synonym: "dibenzo-p-dioxin catabolism" EXACT [] synonym: "dibenzo-p-dioxin degradation" EXACT [] xref: MetaCyc:P661-PWY is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019342 name: trypanothione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355] synonym: "trypanothione anabolism" EXACT [] synonym: "trypanothione biosynthesis" EXACT [] synonym: "trypanothione formation" EXACT [] synonym: "trypanothione synthesis" EXACT [] xref: MetaCyc:TRYPANOSYN-PWY is_a: GO:0046206 ! trypanothione metabolic process is_a: GO:1901687 ! glutathione derivative biosynthetic process [Term] id: GO:0019343 name: cysteine biosynthetic process via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] synonym: "cysteine anabolism via cystathionine" EXACT [] synonym: "cysteine formation via cystathionine" EXACT [] synonym: "cysteine synthesis via cystathionine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019344 name: cysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine anabolism" EXACT [] synonym: "cysteine biosynthesis" EXACT [] synonym: "cysteine formation" EXACT [] synonym: "cysteine synthesis" EXACT [] xref: MIPS_funcat:01.01.09.03.01 is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0019345 name: cysteine biosynthetic process via S-sulfo-L-cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators] synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019346 name: transsulfuration namespace: biological_process def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801] synonym: "homocysteine-cysteine interconversion" NARROW [] synonym: "transsulphuration" EXACT [] xref: MetaCyc:PWY-801 xref: Wikipedia:Transsulfuration_pathway is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0050667 ! homocysteine metabolic process [Term] id: GO:0019347 name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT [] xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process [Term] id: GO:0019348 name: dolichol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] synonym: "dolichol metabolism" EXACT [] is_a: GO:0016093 ! polyprenol metabolic process [Term] id: GO:0019349 name: ribitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732] synonym: "ribitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019350 name: teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732] synonym: "teichoic acid anabolism" EXACT [] synonym: "teichoic acid biosynthesis" EXACT [] synonym: "teichoic acid formation" EXACT [] synonym: "teichoic acid synthesis" EXACT [] xref: MetaCyc:TEICHOICACID-PWY is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0046374 ! teichoic acid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0019351 name: dethiobiotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732] synonym: "desthiobiotin biosynthesis" EXACT [] synonym: "desthiobiotin biosynthetic process" EXACT [] synonym: "dethiobiotin anabolism" EXACT [] synonym: "dethiobiotin biosynthesis" EXACT [] synonym: "dethiobiotin formation" EXACT [] synonym: "dethiobiotin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046450 ! dethiobiotin metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019352 name: protoporphyrinogen IX biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism from glycine" EXACT [] synonym: "protoporphyrinogen IX formation from glycine" EXACT [] synonym: "protoporphyrinogen IX synthesis from glycine" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process [Term] id: GO:0019353 name: protoporphyrinogen IX biosynthetic process from glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT [] synonym: "protoporphyrinogen IX formation from glutamate" EXACT [] synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT [] is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate [Term] id: GO:0019354 name: siroheme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] synonym: "sirohaem biosynthesis" EXACT [] synonym: "sirohaem biosynthetic process" EXACT [] synonym: "siroheme anabolism" EXACT [] synonym: "siroheme biosynthesis" EXACT [] synonym: "siroheme formation" EXACT [] synonym: "siroheme synthase activity" RELATED [] synonym: "siroheme synthesis" EXACT [] xref: AraCyc:PWYQT-62 xref: MetaCyc:PWY-5194 is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046156 ! siroheme metabolic process [Term] id: GO:0019355 name: nicotinamide nucleotide biosynthetic process from aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT [] synonym: "nicotinamide nucleotide formation from aspartate" EXACT [] synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019356 name: nicotinate nucleotide biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators] synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT [] synonym: "nicotinate nucleotide formation from tryptophan" EXACT [] synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process [Term] id: GO:0019357 name: nicotinate nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators] synonym: "nicotinate nucleotide anabolism" EXACT [] synonym: "nicotinate nucleotide biosynthesis" EXACT [] synonym: "nicotinate nucleotide formation" EXACT [] synonym: "nicotinate nucleotide synthesis" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0046497 ! nicotinate nucleotide metabolic process [Term] id: GO:0019358 name: nicotinate nucleotide salvage namespace: biological_process def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT [] synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT [] xref: MetaCyc:PWY-5381 xref: MetaCyc:PYRIDNUCSAL-PWY is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process is_a: GO:0019365 ! pyridine nucleotide salvage [Term] id: GO:0019359 name: nicotinamide nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism" EXACT [] synonym: "nicotinamide nucleotide biosynthesis" EXACT [] synonym: "nicotinamide nucleotide formation" EXACT [] synonym: "nicotinamide nucleotide synthesis" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019360 name: nicotinamide nucleotide biosynthetic process from niacinamide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT [] synonym: "nicotinamide nucleotide formation from niacinamide" EXACT [] synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT [] is_a: GO:0006769 ! nicotinamide metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019361 name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] xref: MetaCyc:P2-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process [Term] id: GO:0019362 name: pyridine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] synonym: "pyridine nucleotide metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019363 name: pyridine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] synonym: "pyridine nucleotide anabolism" EXACT [] synonym: "pyridine nucleotide biosynthesis" EXACT [] synonym: "pyridine nucleotide formation" EXACT [] synonym: "pyridine nucleotide synthesis" EXACT [] xref: MetaCyc:PYRIDNUCSYN-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0019364 name: pyridine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] synonym: "pyridine nucleotide breakdown" EXACT [] synonym: "pyridine nucleotide catabolism" EXACT [] synonym: "pyridine nucleotide degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0019365 name: pyridine nucleotide salvage namespace: biological_process def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl] synonym: "pyridine nucleotide cycling" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0019367 name: fatty acid elongation, saturated fatty acid namespace: biological_process def: "Elongation of a saturated fatty acid chain." [GOC:mah] xref: MetaCyc:FASYN-ELONG-PWY is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019368 name: fatty acid elongation, unsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] xref: MetaCyc:PWY0-862 is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019369 name: arachidonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732] synonym: "arachidonic acid metabolism" EXACT [] xref: Wikipedia:Arachidonic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0019370 name: leukotriene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators] synonym: "leukotriene anabolism" EXACT [] synonym: "leukotriene biosynthesis" EXACT [] synonym: "leukotriene formation" EXACT [] synonym: "leukotriene synthesis" EXACT [] xref: Wikipedia:Leukotriene#Leukotriene_synthesis is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0046456 ! icosanoid biosynthetic process [Term] id: GO:0019371 name: cyclooxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273] is_a: GO:0019369 ! arachidonic acid metabolic process relationship: part_of GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0019372 name: lipoxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0019373 name: epoxygenase P450 pathway namespace: biological_process def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511] is_a: GO:0019369 ! arachidonic acid metabolic process [Term] id: GO:0019374 name: galactolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0019375 name: galactolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid anabolism" EXACT [] synonym: "galactolipid biosynthesis" EXACT [] synonym: "galactolipid formation" EXACT [] synonym: "galactolipid synthesis" EXACT [] is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0019376 name: galactolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid breakdown" EXACT [] synonym: "galactolipid catabolism" EXACT [] synonym: "galactolipid degradation" EXACT [] is_a: GO:0019374 ! galactolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process [Term] id: GO:0019377 name: glycolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] synonym: "glycolipid breakdown" EXACT [] synonym: "glycolipid catabolism" EXACT [] synonym: "glycolipid degradation" EXACT [] xref: MIPS_funcat:01.06.04.03 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0019379 name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) namespace: biological_process def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT [] xref: MetaCyc:SO4ASSIM-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019380 name: 3-phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai] synonym: "3-phenylpropionate breakdown" EXACT [] synonym: "3-phenylpropionate catabolism" EXACT [] synonym: "3-phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY xref: MetaCyc:P281-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018962 ! 3-phenylpropionate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019381 name: atrazine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, UM-BBD_pathwayID:atr] synonym: "atrazine breakdown" EXACT [] synonym: "atrazine catabolism" EXACT [] synonym: "atrazine degradation" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0018873 ! atrazine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process [Term] id: GO:0019382 name: carbon tetrachloride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators] synonym: "carbon tetrachloride breakdown" EXACT [] synonym: "carbon tetrachloride catabolism" EXACT [] synonym: "carbon tetrachloride degradation" EXACT [] is_a: GO:0018885 ! carbon tetrachloride metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019383 name: (+)-camphor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [UM-BBD_pathwayID:cam] synonym: "(+)-camphor breakdown" EXACT [] synonym: "(+)-camphor catabolism" EXACT [] synonym: "(+)-camphor degradation" EXACT [] xref: MetaCyc:P601-PWY is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0018882 ! (+)-camphor metabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0019384 name: caprolactam catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [GOC:curators] synonym: "caprolactam breakdown" EXACT [] synonym: "caprolactam catabolism" EXACT [] synonym: "caprolactam degradation" EXACT [] xref: MetaCyc:P621-PWY is_a: GO:0018883 ! caprolactam metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019385 name: methanogenesis, from acetate namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai] synonym: "methane biosynthesis from acetate" EXACT [] synonym: "methane biosynthetic process from acetate" EXACT [] xref: MetaCyc:METH-ACETATE-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019386 name: methanogenesis, from carbon dioxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai] synonym: "methane biosynthesis from carbon dioxide" EXACT [] synonym: "methane biosynthetic process from carbon dioxide" EXACT [] xref: MetaCyc:METHANOGENESIS-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019387 name: methanogenesis, from methanol namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai] synonym: "methane biosynthesis from methanol" EXACT [] synonym: "methane biosynthetic process from methanol" EXACT [] xref: MetaCyc:METHFORM-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019388 name: galactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732] synonym: "galactose breakdown" EXACT [] synonym: "galactose catabolism" EXACT [] synonym: "galactose degradation" EXACT [] xref: MetaCyc:GALDEG-PWY is_a: GO:0006012 ! galactose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019389 name: glucuronoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732] synonym: "glucuronide metabolic process" EXACT [] synonym: "glucuronide metabolism" EXACT [] synonym: "glucuronoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019390 name: glucuronoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] synonym: "glucuronide biosynthesis" EXACT [] synonym: "glucuronide biosynthetic process" EXACT [] synonym: "glucuronoside anabolism" EXACT [] synonym: "glucuronoside biosynthesis" EXACT [] synonym: "glucuronoside formation" EXACT [] synonym: "glucuronoside synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019391 name: glucuronoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] synonym: "glucuronide catabolic process" EXACT [] synonym: "glucuronide catabolism" EXACT [] synonym: "glucuronoside breakdown" EXACT [] synonym: "glucuronoside catabolism" EXACT [] synonym: "glucuronoside degradation" EXACT [] xref: MetaCyc:GLUCUROCAT-PWY is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019392 name: glucarate metabolic process namespace: biological_process alt_id: GO:0019581 def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732] synonym: "glucarate metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019393 name: glucarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732] synonym: "glucarate anabolism" EXACT [] synonym: "glucarate biosynthesis" EXACT [] synonym: "glucarate formation" EXACT [] synonym: "glucarate synthesis" EXACT [] is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019578 ! aldaric acid biosynthetic process [Term] id: GO:0019394 name: glucarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732] synonym: "glucarate breakdown" EXACT [] synonym: "glucarate catabolism" EXACT [] synonym: "glucarate degradation" EXACT [] xref: MetaCyc:GLUCARDEG-PWY is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019579 ! aldaric acid catabolic process [Term] id: GO:0019395 name: fatty acid oxidation namespace: biological_process def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY] xref: MetaCyc:FAO-PWY xref: MIPS_funcat:02.25 is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0034440 ! lipid oxidation [Term] id: GO:0019396 name: gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl] synonym: "gallate breakdown" EXACT [] synonym: "gallate catabolism" EXACT [] synonym: "gallate degradation" EXACT [] synonym: "gallic acid catabolic process" EXACT [] synonym: "gallic acid catabolism" EXACT [] is_a: GO:0018918 ! gallate metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019397 name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl] synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-I-PWY is_a: GO:0042195 ! aerobic gallate catabolic process [Term] id: GO:0019398 name: gallate catabolic process via gallate dioxygenase activity namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase." [GOC:bf, GOC:jl] synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" BROAD [GOC:bf] synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-II-PWY is_a: GO:0042195 ! aerobic gallate catabolic process relationship: has_part GO:0036238 ! gallate dioxygenase activity [Term] id: GO:0019399 name: cyclohexanol oxidation namespace: biological_process def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY] xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY is_a: GO:0018891 ! cyclohexanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019400 name: alditol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019401 name: alditol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol anabolism" EXACT [] synonym: "alditol biosynthesis" EXACT [] synonym: "alditol formation" EXACT [] synonym: "alditol synthesis" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0019402 name: galactitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019403 name: galactitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol anabolism" EXACT [] synonym: "galactitol biosynthesis" EXACT [] synonym: "galactitol formation" EXACT [] synonym: "galactitol synthesis" EXACT [] is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0019404 name: galactitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol breakdown" EXACT [] synonym: "galactitol catabolism" EXACT [] synonym: "galactitol degradation" EXACT [] xref: MetaCyc:GALACTITOLCAT-PWY is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0019405 name: alditol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol breakdown" EXACT [] synonym: "alditol catabolism" EXACT [] synonym: "alditol degradation" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019406 name: hexitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol anabolism" EXACT [] synonym: "hexitol biosynthesis" EXACT [] synonym: "hexitol formation" EXACT [] synonym: "hexitol synthesis" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019401 ! alditol biosynthetic process [Term] id: GO:0019407 name: hexitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol breakdown" EXACT [] synonym: "hexitol catabolism" EXACT [] synonym: "hexitol degradation" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019408 name: dolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] synonym: "dolichol anabolism" EXACT [] synonym: "dolichol biosynthesis" EXACT [] synonym: "dolichol formation" EXACT [] synonym: "dolichol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0019348 ! dolichol metabolic process [Term] id: GO:0019409 name: aerobic respiration, using ammonia as electron donor namespace: biological_process def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY] synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah] xref: MetaCyc:AMMOXID-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019410 name: aerobic respiration, using carbon monoxide as electron donor namespace: biological_process def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019411 name: aerobic respiration, using ferrous ions as electron donor namespace: biological_process def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019412 name: aerobic respiration, using hydrogen as electron donor namespace: biological_process def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY] synonym: "hydrogen oxidation" BROAD [] xref: MetaCyc:P283-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019413 name: acetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate anabolism" EXACT [] synonym: "acetate biosynthesis" EXACT [] synonym: "acetate formation" EXACT [] synonym: "acetate synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0019414 name: aerobic respiration, using sulfur or sulfate as electron donor namespace: biological_process def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697] synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019415 name: acetate biosynthetic process from carbon monoxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators] synonym: "acetate anabolism from carbon monoxide" EXACT [] synonym: "acetate formation from carbon monoxide" EXACT [] synonym: "acetate synthesis from carbon monoxide" EXACT [] synonym: "carbon monoxide dehydrogenase pathway" EXACT [] is_a: GO:0019413 ! acetate biosynthetic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019416 name: polythionate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY] xref: MetaCyc:THIOSULFOX-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019417 name: sulfur oxidation namespace: biological_process def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] synonym: "sulphur oxidation" EXACT [] xref: MIPS_funcat:01.02.01.15 is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019418 name: sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] synonym: "sulphide oxidation" EXACT [] xref: MetaCyc:P222-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019419 name: sulfate reduction namespace: biological_process alt_id: GO:0019421 def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY] synonym: "assimilatory sulfate reduction" NARROW [] synonym: "assimilatory sulphate reduction" NARROW [] synonym: "sulfate reduction, APS pathway" NARROW [] synonym: "sulphate reduction" EXACT [] synonym: "sulphate reduction, APS pathway" NARROW [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019420 name: dissimilatory sulfate reduction namespace: biological_process def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] synonym: "dissimilatory sulphate reduction" EXACT [] xref: MetaCyc:DISSULFRED-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019422 name: disproportionation of elemental sulfur namespace: biological_process def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY] synonym: "disproportionation of elemental sulphur" EXACT [] xref: MetaCyc:P203-PWY is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019423 name: sulfur oxidation, ferric ion-dependent namespace: biological_process def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY] synonym: "sulphur oxidation, ferric ion-dependent" EXACT [] xref: MetaCyc:FESULFOX-PWY is_a: GO:0019417 ! sulfur oxidation [Term] id: GO:0019424 name: sulfide oxidation, using siroheme sulfite reductase namespace: biological_process alt_id: GO:0019425 def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY] synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT [] synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED [] synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED [] synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT [] synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED [] xref: MetaCyc:P223-PWY is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0019426 name: bisulfite reduction namespace: biological_process def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY] synonym: "bisulphite reduction" EXACT [] xref: MetaCyc:P224-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019427 name: acetyl-CoA biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY] synonym: "acetate utilization" RELATED [] synonym: "acetyl-CoA anabolism from acetate" EXACT [] synonym: "acetyl-CoA formation from acetate" EXACT [] synonym: "acetyl-CoA synthesis from acetate" EXACT [] xref: MetaCyc:ACETATEUTIL-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019428 name: allantoin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators] synonym: "allantoin anabolism" EXACT [] synonym: "allantoin biosynthesis" EXACT [] synonym: "allantoin formation" EXACT [] synonym: "allantoin synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019429 name: fluorene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators] synonym: "fluorene breakdown" EXACT [] synonym: "fluorene catabolism" EXACT [] synonym: "fluorene degradation" EXACT [] xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY is_a: GO:0018917 ! fluorene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019430 name: removal of superoxide radicals namespace: biological_process def: "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [GOC:jl] synonym: "cellular detoxification of superoxide radicals" EXACT [GOC:dos] synonym: "removal of O2-" EXACT [] synonym: "removal of oxygen free radicals" EXACT [] xref: MetaCyc:DETOX1-PWY is_a: GO:0006801 ! superoxide metabolic process is_a: GO:0098869 ! cellular oxidant detoxification relationship: part_of GO:0071451 ! cellular response to superoxide [Term] id: GO:0019431 name: acetyl-CoA biosynthetic process from ethanol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators] synonym: "acetyl-CoA anabolism from ethanol" EXACT [] synonym: "acetyl-CoA formation from ethanol" EXACT [] synonym: "acetyl-CoA synthesis from ethanol" EXACT [] xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019432 name: triglyceride biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732] synonym: "triacylglycerol biosynthesis" EXACT [] synonym: "triacylglycerol biosynthetic process" EXACT [] synonym: "triglyceride anabolism" EXACT [] synonym: "triglyceride biosynthesis" EXACT [] synonym: "triglyceride formation" EXACT [] synonym: "triglyceride synthesis" EXACT [] xref: MetaCyc:TRIGLSYN-PWY is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0019433 name: triglyceride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] synonym: "triacylglycerol catabolic process" EXACT [] synonym: "triacylglycerol catabolism" EXACT [] synonym: "triglyceride breakdown" EXACT [] synonym: "triglyceride catabolism" EXACT [] synonym: "triglyceride degradation" EXACT [] xref: MetaCyc:LIPAS-PWY is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0019434 name: sophorosyloxydocosanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] synonym: "sophorosyloxydocosanoate metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0019435 name: sophorosyloxydocosanoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] synonym: "sophorosyloxydocosanoate anabolism" EXACT [] synonym: "sophorosyloxydocosanoate biosynthesis" EXACT [] synonym: "sophorosyloxydocosanoate formation" EXACT [] synonym: "sophorosyloxydocosanoate synthesis" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process [Term] id: GO:0019436 name: sophorosyloxydocosanoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] synonym: "sophorosyloxydocosanoate breakdown" EXACT [] synonym: "sophorosyloxydocosanoate catabolism" EXACT [] synonym: "sophorosyloxydocosanoate degradation" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] xref: MIPS_funcat:01.05.01.03.09 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019439 name: aromatic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound breakdown" EXACT [] synonym: "aromatic compound catabolism" EXACT [] synonym: "aromatic compound degradation" EXACT [] synonym: "aromatic hydrocarbon catabolic process" NARROW [] synonym: "aromatic hydrocarbon catabolism" NARROW [] xref: MIPS_funcat:01.05.01.01.09 xref: MIPS_funcat:01.05.01.01.11 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0019440 name: tryptophan catabolic process to indole-3-acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators] synonym: "tryptophan breakdown to indole-3-acetate" EXACT [] synonym: "tryptophan catabolic process to IAA" EXACT [] synonym: "tryptophan catabolic process to indoleacetic acid" EXACT [] synonym: "tryptophan catabolism to indoleacetic acid" EXACT [] synonym: "tryptophan degradation to indole-3-acetate" EXACT [] xref: MetaCyc:TRPIAACAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009683 ! indoleacetic acid metabolic process [Term] id: GO:0019441 name: tryptophan catabolic process to kynurenine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] synonym: "tryptophan breakdown to kynurenine" EXACT [] synonym: "tryptophan degradation to kynurenine" EXACT [] xref: MetaCyc:TRPKYNCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0070189 ! kynurenine metabolic process [Term] id: GO:0019442 name: tryptophan catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators] synonym: "tryptophan breakdown to acetyl-CoA" EXACT [] synonym: "tryptophan degradation to acetyl-CoA" EXACT [] xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0006569 ! tryptophan catabolic process [Term] id: GO:0019443 name: obsolete tryptophan catabolic process, using tryptophanase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl] comment: This term was made obsolete because it refers to a one-step pathway. synonym: "tryptophan breakdown, using tryptophanase" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" EXACT [] synonym: "tryptophan degradation, using tryptophanase" EXACT [] is_obsolete: true consider: GO:0006569 consider: GO:0009034 [Term] id: GO:0019444 name: tryptophan catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators] synonym: "tryptophan breakdown to catechol" EXACT [] synonym: "tryptophan degradation to catechol" EXACT [] xref: MetaCyc:TRPCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process [Term] id: GO:0019445 name: tyrosine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators] synonym: "tyrosine breakdown to fumarate" EXACT [] synonym: "tyrosine degradation to fumarate" EXACT [] xref: MetaCyc:TYRFUMCAT-PWY is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006572 ! tyrosine catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019446 name: obsolete tyrosine catabolic process to phosphoenolpyruvate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] comment: The reason for obsoletion is that there is no evidence that this is a real process. synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT [] synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT [] is_obsolete: true [Term] id: GO:0019447 name: D-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732] synonym: "D-cysteine breakdown" EXACT [] synonym: "D-cysteine catabolism" EXACT [] synonym: "D-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046438 ! D-cysteine metabolic process [Term] id: GO:0019448 name: L-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:jsg, GOC:mah] synonym: "L-cysteine breakdown" EXACT [] synonym: "L-cysteine catabolism" EXACT [] synonym: "L-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0046439 ! L-cysteine metabolic process [Term] id: GO:0019449 name: L-cysteine catabolic process to hypotaurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] synonym: "L-cysteine breakdown to hypotaurine" EXACT [] synonym: "L-cysteine degradation to hypotaurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019450 name: L-cysteine catabolic process to pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators] synonym: "L-cysteine breakdown to pyruvate" EXACT [] synonym: "L-cysteine degradation to pyruvate" EXACT [] xref: MetaCyc:LCYSDEG-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019451 name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl] synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT [] synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT [] xref: MetaCyc:CYSTEINE-DEG-PWY is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate [Term] id: GO:0019452 name: L-cysteine catabolic process to taurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] synonym: "L-cysteine breakdown to taurine" EXACT [] synonym: "L-cysteine degradation to taurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process is_a: GO:0019530 ! taurine metabolic process [Term] id: GO:0019453 name: L-cysteine catabolic process via cystine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators] synonym: "L-cysteine breakdown via cystine" EXACT [] synonym: "L-cysteine degradation via cystine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019454 name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT [] synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019455 name: L-cysteine catabolic process via cystine, using cystine reductase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT [] synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019456 name: L-cysteine catabolic process via cystine, using cysteine transaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT [] synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019457 name: methionine catabolic process to succinyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators] synonym: "methionine breakdown to succinyl-CoA" EXACT [] synonym: "methionine degradation to succinyl-CoA" EXACT [] xref: MetaCyc:METHIONINE-DEG1-PWY is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019458 name: methionine catabolic process via 2-oxobutanoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators] synonym: "methionine breakdown via 2-oxobutanoate" EXACT [] synonym: "methionine degradation via 2-oxobutanoate" EXACT [] xref: MetaCyc:PWY-701 is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019460 name: glutamine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators] synonym: "glutamate catabolic process to fumarate" NARROW [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate" EXACT [] synonym: "glutamine degradation to fumarate" EXACT [] is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0006543 ! glutamine catabolic process relationship: has_part GO:0019550 ! glutamate catabolic process to aspartate [Term] id: GO:0019461 name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH) namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl] synonym: "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)" RELATED [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamine degradation to fumarate, using glutamate synthase (NADPH)" EXACT [] xref: MetaCyc:GLUTAMINEFUM-PWY is_a: GO:0019460 ! glutamine catabolic process to fumarate relationship: has_part GO:0004355 ! glutamate synthase (NADPH) activity [Term] id: GO:0019462 name: glutamine catabolic process to fumarate, using glutaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl] synonym: "glutamate catabolic process to fumarate, using glutaminase" RELATED [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT [] synonym: "glutamine degradation to fumarate, using glutaminase" NARROW [] xref: MetaCyc:GLUTAMINDEG-PWY is_a: GO:0006538 ! glutamate catabolic process relationship: has_part GO:0004359 ! glutaminase activity [Term] id: GO:0019463 name: glycine catabolic process to creatine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators] synonym: "glycine breakdown to creatine" EXACT [] synonym: "glycine degradation to creatine" EXACT [] xref: MetaCyc:GLYCGREAT-PWY is_a: GO:0006546 ! glycine catabolic process is_a: GO:0006600 ! creatine metabolic process [Term] id: GO:0019464 name: glycine decarboxylation via glycine cleavage system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] synonym: "glycine cleavage system" BROAD [] xref: MetaCyc:GLYCLEAV-PWY is_a: GO:0006546 ! glycine catabolic process [Term] id: GO:0019465 name: aspartate transamidation namespace: biological_process def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732] xref: MetaCyc:ASPARTATE-DEG1-PWY xref: MetaCyc:ASPARTATESYN-PWY is_a: GO:0006533 ! aspartate catabolic process [Term] id: GO:0019466 name: ornithine catabolic process via proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators] synonym: "ornithine breakdown via proline" EXACT [] synonym: "ornithine degradation via proline" EXACT [] xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019467 name: ornithine catabolic process, by decarboxylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators] synonym: "ornithine breakdown, by decarboxylation" EXACT [] synonym: "ornithine degradation, by decarboxylation" EXACT [] xref: MetaCyc:ORNDEG-PWY is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019468 name: nopaline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732] synonym: "nopaline breakdown" EXACT [] synonym: "nopaline catabolism" EXACT [] synonym: "nopaline degradation" EXACT [] xref: MetaCyc:NOPALINEDEG-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046418 ! nopaline metabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019469 name: octopine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732] synonym: "octopine breakdown" EXACT [] synonym: "octopine catabolism" EXACT [] synonym: "octopine degradation" EXACT [] xref: MetaCyc:OCTOPINEDEG-PWY is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046419 ! octopine metabolic process [Term] id: GO:0019470 name: 4-hydroxyproline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] synonym: "4-hydroxyproline breakdown" EXACT [] synonym: "4-hydroxyproline catabolism" EXACT [] synonym: "4-hydroxyproline degradation" EXACT [] xref: MetaCyc:HYDROXYPRODEG-PWY xref: MIPS_funcat:01.01.03.04.02 is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019471 name: 4-hydroxyproline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [GOC:ai] synonym: "4-hydroxyproline metabolism" EXACT [] xref: MIPS_funcat:01.01.03.04 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0019472 name: 4-hydroxyproline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] synonym: "4-hydroxyproline anabolism" EXACT [] synonym: "4-hydroxyproline biosynthesis" EXACT [] synonym: "4-hydroxyproline formation" EXACT [] synonym: "4-hydroxyproline synthesis" EXACT [] xref: MIPS_funcat:01.01.03.04.01 is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019473 name: L-lysine catabolic process to glutarate, by acetylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators] synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT [] synonym: "L-lysine degradation to glutarate, by acetylation" EXACT [] xref: MetaCyc:LYSDEGII-PWY is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019474 name: L-lysine catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators] synonym: "L-lysine breakdown to acetyl-CoA" EXACT [] synonym: "L-lysine degradation to acetyl-CoA" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019475 name: L-lysine catabolic process to acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators] synonym: "L-lysine breakdown to acetate" EXACT [] synonym: "L-lysine degradation to acetate" EXACT [] synonym: "lysine fermentation" EXACT [] xref: MetaCyc:P163-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0019477 ! L-lysine catabolic process is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019476 name: D-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-lysine breakdown" EXACT [] synonym: "D-lysine catabolism" EXACT [] synonym: "D-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046441 ! D-lysine metabolic process [Term] id: GO:0019477 name: L-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-lysine breakdown" EXACT [] synonym: "L-lysine catabolism" EXACT [] synonym: "L-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046440 ! L-lysine metabolic process [Term] id: GO:0019478 name: D-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] synonym: "D-amino acid breakdown" EXACT [] synonym: "D-amino acid catabolism" EXACT [] synonym: "D-amino acid degradation" EXACT [] is_a: GO:0046416 ! D-amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019479 name: L-alanine oxidation to D-lactate and ammonia namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY] xref: MetaCyc:ALACAT2-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019480 name: L-alanine oxidation to pyruvate via D-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY] xref: MetaCyc:ALADEG-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019481 name: L-alanine catabolic process, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators] synonym: "L-alanine breakdown, by transamination" EXACT [] synonym: "L-alanine degradation, by transamination" EXACT [] xref: MetaCyc:ALANINE-DEG3-PWY is_a: GO:0042853 ! L-alanine catabolic process [Term] id: GO:0019482 name: beta-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine metabolism" EXACT [] xref: Wikipedia:Beta-alanine is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019483 name: beta-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine anabolism" EXACT [] synonym: "beta-alanine biosynthesis" EXACT [] synonym: "beta-alanine formation" EXACT [] synonym: "beta-alanine synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0019482 ! beta-alanine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0019484 name: beta-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine breakdown" EXACT [] synonym: "beta-alanine catabolism" EXACT [] synonym: "beta-alanine degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019482 ! beta-alanine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process [Term] id: GO:0019485 name: beta-alanine catabolic process to L-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators] synonym: "beta-alanine breakdown to L-alanine" EXACT [] synonym: "beta-alanine degradation to L-alanine" EXACT [] is_a: GO:0019484 ! beta-alanine catabolic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0019486 name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators] synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT [] synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT [] xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY is_a: GO:0019484 ! beta-alanine catabolic process [Term] id: GO:0019487 name: anaerobic acetylene catabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544] synonym: "anaerobic acetylene breakdown" EXACT [] synonym: "anaerobic acetylene catabolism" EXACT [] synonym: "anaerobic acetylene degradation" EXACT [] synonym: "anaerobic ethyne catabolic process" EXACT [] synonym: "anaerobic ethyne catabolism" EXACT [] xref: MetaCyc:P161-PWY is_a: GO:0018864 ! acetylene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043454 ! alkyne catabolic process [Term] id: GO:0019488 name: ribitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY] synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "ribitol degradation to xylulose 5-phosphate" EXACT [] synonym: "ribitol utilization" RELATED [] xref: MetaCyc:RIBITOLUTIL-PWY is_a: GO:0046363 ! ribitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019489 name: methylgallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] synonym: "methylgallate metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0019490 name: 2-aminobenzenesulfonate desulfonation namespace: biological_process def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] xref: MetaCyc:2ASDEG-PWY is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process [Term] id: GO:0019491 name: ectoine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] synonym: "ectoine anabolism" EXACT [] synonym: "ectoine biosynthesis" EXACT [] synonym: "ectoine formation" EXACT [] synonym: "ectoine synthesis" EXACT [] xref: MetaCyc:P101-PWY is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042399 ! ectoine metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019492 name: proline salvage namespace: biological_process def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl] synonym: "proline cycling" EXACT [] is_a: GO:0006561 ! proline biosynthetic process is_a: GO:0043102 ! amino acid salvage [Term] id: GO:0019493 name: arginine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] synonym: "arginine breakdown to proline" EXACT [] synonym: "arginine degradation to proline" EXACT [] xref: MetaCyc:ARG-PRO-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006560 ! proline metabolic process [Term] id: GO:0019495 name: proline catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "proline breakdown to 2-oxoglutarate" EXACT [] synonym: "proline catabolic process to 2-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-oxoglutarate" EXACT [] synonym: "proline catabolism to 2-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-oxoglutarate" EXACT [] synonym: "proline degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0019496 name: serine-isocitrate lyase pathway namespace: biological_process def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534] xref: MIPS_funcat:01.05.01.01.05.01 is_a: GO:0006730 ! one-carbon metabolic process [Term] id: GO:0019497 name: hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] synonym: "hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0019498 name: n-octane oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY] xref: MetaCyc:P221-PWY is_a: GO:0018939 ! n-octane metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019499 name: cyanide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732] synonym: "cyanide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019500 name: cyanide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732] synonym: "cyanide breakdown" EXACT [] synonym: "cyanide catabolism" EXACT [] synonym: "cyanide degradation" EXACT [] xref: MetaCyc:P401-PWY is_a: GO:0019499 ! cyanide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019501 name: arsonoacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl] synonym: "arsonoacetate breakdown" EXACT [] synonym: "arsonoacetate catabolism" EXACT [] synonym: "arsonoacetate degradation" EXACT [] xref: MetaCyc:P482-PWY is_a: GO:0018872 ! arsonoacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019502 name: stachydrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators, MetaCyc:CPD-821] synonym: "stachydrine metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0019503 name: stachydrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] synonym: "stachydrine anabolism" EXACT [] synonym: "stachydrine biosynthesis" EXACT [] synonym: "stachydrine formation" EXACT [] synonym: "stachydrine synthesis" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019504 name: stachydrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] synonym: "stachydrine breakdown" EXACT [] synonym: "stachydrine catabolism" EXACT [] synonym: "stachydrine degradation" EXACT [] xref: MetaCyc:P561-PWY is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019505 name: resorcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm] synonym: "1,3-benzenediol metabolic process" EXACT [] synonym: "1,3-benzenediol metabolism" EXACT [] synonym: "1,3-dihydroxybenzene metabolic process" EXACT [] synonym: "1,3-dihydroxybenzene metabolism" EXACT [] synonym: "resorcinol metabolism" EXACT [] xref: MetaCyc:P343-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0019506 name: phenylmercury acetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] synonym: "phenylmercury acetate breakdown" EXACT [] synonym: "phenylmercury acetate catabolism" EXACT [] synonym: "phenylmercury acetate degradation" EXACT [] xref: MetaCyc:P641-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046412 ! phenylmercury acetate metabolic process is_a: GO:0046413 ! organomercury catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019507 name: pyridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:curators] synonym: "pyridine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019508 name: 2,5-dihydroxypyridine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722] synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine utilization" RELATED [] synonym: "maleamate pathway" EXACT [] synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT [] xref: MetaCyc:PWY-722 is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process [Term] id: GO:0019509 name: L-methionine salvage from methylthioadenosine namespace: biological_process def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361] synonym: "methionine recycling" NARROW [] synonym: "methionine regeneration" NARROW [] synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah] synonym: "methionine salvage pathway" EXACT [] xref: MetaCyc:PWY-4361 is_a: GO:0071267 ! L-methionine salvage [Term] id: GO:0019510 name: S-adenosylhomocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732] synonym: "S-adenosylhomocysteine breakdown" EXACT [] synonym: "S-adenosylhomocysteine catabolism" EXACT [] synonym: "S-adenosylhomocysteine degradation" EXACT [] xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019511 name: peptidyl-proline hydroxylation namespace: biological_process alt_id: GO:0006472 def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0019512 name: lactose catabolic process via tagatose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators] synonym: "lactose breakdown via tagatose-6-phosphate" EXACT [] synonym: "lactose degradation via tagatose-6-phosphate" EXACT [] xref: MetaCyc:LACTOSECAT-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019513 name: lactose catabolic process, using glucoside 3-dehydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:LACTOSEUTIL-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019514 name: obsolete lactose hydrolysis namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction. synonym: "lactose hydrolysis" EXACT [] is_obsolete: true consider: GO:0004565 [Term] id: GO:0019515 name: lactose catabolic process via UDP-galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators] synonym: "lactose breakdown via UDP-galactose" EXACT [] synonym: "lactose degradation via UDP-galactose" EXACT [] is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019516 name: lactate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019517 name: L-threonine catabolic process to D-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY] synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf] synonym: "L-threonine catabolic process to (R)-lactate" BROAD [GOC:bf] synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf] synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] xref: MetaCyc:THRDLCTCAT-PWY is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006567 ! threonine catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019518 name: L-threonine catabolic process to glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine." [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY] synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah] synonym: "threonine catabolic process to glycine" BROAD [GOC:bf] xref: MetaCyc:THREONINE-DEG2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006567 ! threonine catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019519 name: pentitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0019520 name: aldonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] synonym: "aldonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019521 name: D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] synonym: "D-gluconate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019522 name: ketogluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] synonym: "ketogluconate metabolism" EXACT [] xref: MetaCyc:KETOGLUCONMET-PWY is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019523 name: L-idonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] synonym: "L-idonate metabolism" EXACT [] xref: MetaCyc:IDNCAT-PWY is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019524 name: keto-D-gluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] synonym: "keto-D-gluconate breakdown" EXACT [] synonym: "keto-D-gluconate catabolism" EXACT [] synonym: "keto-D-gluconate degradation" EXACT [] xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY is_a: GO:0019525 ! keto-D-gluconate metabolic process is_a: GO:0046181 ! ketogluconate catabolic process [Term] id: GO:0019525 name: keto-D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] synonym: "keto-D-gluconate metabolism" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process [Term] id: GO:0019526 name: pentitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol anabolism" EXACT [] synonym: "pentitol biosynthesis" EXACT [] synonym: "pentitol formation" EXACT [] synonym: "pentitol synthesis" EXACT [] is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019527 name: pentitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol breakdown" EXACT [] synonym: "pentitol catabolism" EXACT [] synonym: "pentitol degradation" EXACT [] is_a: GO:0019405 ! alditol catabolic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019528 name: D-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY] synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol degradation" RELATED [] synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol utilization" RELATED [] xref: MetaCyc:DARABITOLUTIL-PWY is_a: GO:0051159 ! D-arabitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019529 name: taurine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine breakdown" EXACT [] synonym: "taurine catabolism" EXACT [] synonym: "taurine degradation" EXACT [] xref: MetaCyc:TAURINEDEG-PWY is_a: GO:0019530 ! taurine metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046306 ! alkanesulfonate catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019530 name: taurine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019531 name: oxalate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] synonym: "oxalic acid transporter activity" EXACT [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0019532 ! oxalate transport [Term] id: GO:0019532 name: oxalate transport namespace: biological_process def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] synonym: "ethanedioate transport" EXACT [] synonym: "ethanedioic acid transport" EXACT [] synonym: "oxalic acid transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0019533 name: cellobiose transport namespace: biological_process def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0019534 name: toxin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1901998 ! toxin transport [Term] id: GO:0019535 name: ferric-vibriobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0015603 ! iron chelate transmembrane transporter activity [Term] id: GO:0019536 name: vibriobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] synonym: "vibriobactin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019537 name: vibriobactin biosynthetic process namespace: biological_process alt_id: GO:0031195 alt_id: GO:0031196 def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] synonym: "vibriobactin anabolism" EXACT [] synonym: "vibriobactin biosynthesis" EXACT [] synonym: "vibriobactin biosynthetic process, peptide formation" NARROW [] synonym: "vibriobactin biosynthetic process, peptide modification" NARROW [] synonym: "vibriobactin formation" EXACT [] synonym: "vibriobactin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019536 ! vibriobactin metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019539 name: siderophore biosynthetic process from hydroxamic acid namespace: biological_process alt_id: GO:0031197 alt_id: GO:0031198 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators] synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW [] synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW [] synonym: "siderophore anabolism from hydroxamic acid" EXACT [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide modification" NARROW [] synonym: "siderophore formation from hydroxamic acid" EXACT [] synonym: "siderophore synthesis from hydroxamic acid" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019540 name: siderophore biosynthetic process from catechol namespace: biological_process alt_id: GO:0031189 alt_id: GO:0031190 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators] synonym: "siderochrome biosynthesis from catechol" NARROW [] synonym: "siderochrome biosynthetic process from catechol" NARROW [] synonym: "siderophore anabolism from catechol" EXACT [] synonym: "siderophore biosynthetic process from catechol, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from catechol, peptide modification" NARROW [] synonym: "siderophore formation from catechol" EXACT [] synonym: "siderophore synthesis from catechol" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0019541 name: propionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732, KEGG:C00163, MetaCyc:PROPIONATE] synonym: "propanoate metabolic process" EXACT [] synonym: "propanoate metabolism" EXACT [] synonym: "propionate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019542 name: propionate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators] synonym: "propionate anabolism" EXACT [] synonym: "propionate biosynthesis" EXACT [] synonym: "propionate formation" EXACT [] synonym: "propionate synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0019543 name: propionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators] synonym: "propionate breakdown" EXACT [] synonym: "propionate catabolism" EXACT [] synonym: "propionate degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019626 ! short-chain fatty acid catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019544 name: arginine catabolic process to glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators] synonym: "arginine breakdown to glutamate" EXACT [] synonym: "arginine degradation to glutamate" EXACT [] xref: MetaCyc:ARG-GLU-PWY xref: MetaCyc:ARGASEDEG-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006536 ! glutamate metabolic process [Term] id: GO:0019545 name: arginine catabolic process to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators] synonym: "arginine breakdown to succinate" EXACT [] synonym: "arginine degradation to succinate" EXACT [] xref: MetaCyc:ARGDEG-III-PWY xref: MetaCyc:ARGDEG-IV-PWY xref: MetaCyc:ARGDEG-V-PWY xref: MetaCyc:AST-PWY is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019546 name: arginine deiminase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY] xref: MetaCyc:ARGDEGRAD-PWY is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019547 name: arginine catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators] synonym: "arginine breakdown to ornithine" EXACT [] synonym: "arginine degradation to ornithine" EXACT [] is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019548 name: arginine catabolic process to spermine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators] synonym: "arginine breakdown to spermine" EXACT [] synonym: "arginine degradation to spermine" EXACT [] xref: MetaCyc:ARGSPECAT-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0019549 name: glutamate catabolic process to succinate via succinate semialdehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321] comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. synonym: "glutamate breakdown to succinate" BROAD [] synonym: "glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity" EXACT [] synonym: "glutamate degradation to succinate" BROAD [] xref: MetaCyc:PWY-4321 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006540 ! glutamate decarboxylation to succinate relationship: has_part GO:0034387 ! 4-aminobutyrate:pyruvate transaminase activity [Term] id: GO:0019550 name: glutamate catabolic process to aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators] synonym: "glutamate breakdown to aspartate" EXACT [] synonym: "glutamate degradation to aspartate" EXACT [] xref: MetaCyc:GLUTDEG-PWY is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019551 name: glutamate catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "glutamate breakdown to 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation to 2-oxoglutarate" EXACT [] xref: MetaCyc:GLUTAMATE-DEG1-PWY xref: MetaCyc:PWY-5766 is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019552 name: glutamate catabolic process via 2-hydroxyglutarate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY] synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT [] xref: MetaCyc:P162-PWY is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019553 name: glutamate catabolic process via L-citramalate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators] synonym: "glutamate breakdown via L-citramalate" EXACT [] synonym: "glutamate degradation via L-citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019554 name: glutamate catabolic process to oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators] synonym: "glutamate breakdown to oxaloacetate" EXACT [] synonym: "glutamate degradation to oxaloacetate" EXACT [] is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019555 name: glutamate catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators] synonym: "glutamate breakdown to ornithine" EXACT [] synonym: "glutamate degradation to ornithine" EXACT [] xref: MetaCyc:GLUTORN-PWY is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019556 name: histidine catabolic process to glutamate and formamide namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators] synonym: "histidine breakdown to glutamate and formamide" EXACT [] synonym: "histidine degradation to glutamate and formamide" EXACT [] xref: MetaCyc:HISDEG-PWY is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process is_a: GO:0043606 ! formamide metabolic process [Term] id: GO:0019557 name: histidine catabolic process to glutamate and formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators] synonym: "histidine breakdown to glutamate and formate" EXACT [] synonym: "histidine degradation to glutamate and formate" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019558 name: histidine catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "histidine breakdown to 2-oxoglutarate" EXACT [] synonym: "histidine catabolic process to 2-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT [] synonym: "histidine catabolism to 2-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-oxoglutarate" EXACT [] synonym: "histidine degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019559 name: histidine catabolic process to imidazol-5-yl-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators] synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT [] synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT [] xref: MetaCyc:HISTDEG-PWY is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019560 name: histidine catabolic process to hydantoin-5-propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators] synonym: "histidine breakdown to hydantoin-5-propionate" EXACT [] synonym: "histidine degradation to hydantoin-5-propionate" EXACT [] xref: MetaCyc:HISHP-PWY is_a: GO:0006548 ! histidine catabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019561 name: anaerobic phenylalanine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY] xref: MetaCyc:ANAPHENOXI-PWY is_a: GO:0006559 ! L-phenylalanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019562 name: obsolete L-phenylalanine catabolic process to phosphoenolpyruvate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] comment: The reason for obsoletion is that there is no evidence that this is a real process. synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT [] synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT [] xref: MetaCyc:PHENYLALANINE-DEG1-PWY is_obsolete: true [Term] id: GO:0019563 name: glycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732] synonym: "glycerol breakdown" EXACT [] synonym: "glycerol catabolism" EXACT [] synonym: "glycerol degradation" EXACT [] xref: MetaCyc:PWY-4261 xref: MetaCyc:PWY0-381 is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019564 name: aerobic glycerol catabolic process namespace: biological_process alt_id: GO:0019565 def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732] synonym: "aerobic glycerol breakdown" EXACT [] synonym: "aerobic glycerol catabolism" EXACT [] synonym: "aerobic glycerol degradation" EXACT [] synonym: "aerobic glycerol fermentation" RELATED [] xref: MetaCyc:PWY0-381 is_a: GO:0019563 ! glycerol catabolic process [Term] id: GO:0019566 name: arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732] synonym: "arabinose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019567 name: arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai] synonym: "arabinose anabolism" EXACT [] synonym: "arabinose biosynthesis" EXACT [] synonym: "arabinose formation" EXACT [] synonym: "arabinose synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019568 name: arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai] synonym: "arabinose breakdown" EXACT [] synonym: "arabinose catabolism" EXACT [] synonym: "arabinose degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019569 name: L-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators] synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:ARABCAT-PWY is_a: GO:0019572 ! L-arabinose catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019570 name: L-arabinose catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT [] synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0019572 ! L-arabinose catabolic process [Term] id: GO:0019571 name: D-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah] synonym: "D-arabinose breakdown" EXACT [] synonym: "D-arabinose catabolism" EXACT [] synonym: "D-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046372 ! D-arabinose metabolic process [Term] id: GO:0019572 name: L-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah] synonym: "L-arabinose breakdown" EXACT [] synonym: "L-arabinose catabolism" EXACT [] synonym: "L-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046373 ! L-arabinose metabolic process [Term] id: GO:0019573 name: D-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators] synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:DARABCAT-PWY is_a: GO:0019571 ! D-arabinose catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019574 name: sucrose catabolic process via 3'-ketosucrose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose." [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose catabolic process to D-glucose" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose catabolic process, using glucoside 3-dehydrogenase" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:SUCROSEUTIL2-PWY is_a: GO:0005987 ! sucrose catabolic process is_a: GO:0006006 ! glucose metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process relationship: has_part GO:0008865 ! fructokinase activity relationship: has_part GO:0048258 ! 3-ketoglucose-reductase activity [Term] id: GO:0019575 name: obsolete sucrose catabolic process, using beta-fructofuranosidase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl] comment: This term was made obsolete because beta-fructofuranosidase (also known as invertase) catalyzes the first step in multiple routes of sucrose catabolism. synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT [] synonym: "sucrose catabolic process, using beta-fructofuranosidase" EXACT [] synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT [] synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT [] xref: MetaCyc:SUCUTIL-PWY is_obsolete: true consider: GO:0004564 consider: GO:0036008 [Term] id: GO:0019576 name: aerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai] synonym: "aerobic fructose breakdown" EXACT [] synonym: "aerobic fructose catabolism" EXACT [] synonym: "aerobic fructose degradation" EXACT [] is_a: GO:0006001 ! fructose catabolic process [Term] id: GO:0019577 name: aldaric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0019578 name: aldaric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid anabolism" EXACT [] synonym: "aldaric acid biosynthesis" EXACT [] synonym: "aldaric acid formation" EXACT [] synonym: "aldaric acid synthesis" EXACT [] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019579 name: aldaric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid breakdown" EXACT [] synonym: "aldaric acid catabolism" EXACT [] synonym: "aldaric acid degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019580 name: galactarate metabolic process namespace: biological_process alt_id: GO:0046393 def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [GOC:pr, ISBN:0198506732] synonym: "D-galactarate metabolic process" RELATED [] synonym: "D-galactarate metabolism" RELATED [] synonym: "galactarate metabolism" EXACT [] synonym: "mucic acid metabolic process" EXACT [] synonym: "mucic acid metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019583 name: galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai] synonym: "galactonate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019584 name: galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai] synonym: "galactonate breakdown" EXACT [] synonym: "galactonate catabolism" EXACT [] synonym: "galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019583 ! galactonate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0019585 name: glucuronate metabolic process namespace: biological_process alt_id: GO:0019699 def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732] synonym: "glucuronate metabolism" EXACT [] xref: Wikipedia:Glucuronic_acid is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019586 name: galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732] synonym: "galacturonate metabolism" EXACT [] is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019588 name: anaerobic glycerol catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah] synonym: "glycerol fermentation" EXACT [] is_a: GO:0019563 ! glycerol catabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019589 name: anaerobic glycerol catabolic process to propane-1,3-diol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY] synonym: "glycerol fermentation to 1,3-propanediol" EXACT [] synonym: "glycerol fermentation to propane-1,3-diol" EXACT [] xref: MetaCyc:GOLPDLCAT-PWY is_a: GO:0019588 ! anaerobic glycerol catabolic process is_a: GO:0051143 ! propanediol metabolic process [Term] id: GO:0019590 name: L-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051158 ! L-arabitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019592 name: mannitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol breakdown" EXACT [] synonym: "mannitol catabolism" EXACT [] synonym: "mannitol degradation" EXACT [] xref: MetaCyc:MANNIDEG-PWY xref: MetaCyc:PWY-3861 is_a: GO:0019407 ! hexitol catabolic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019593 name: mannitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol anabolism" EXACT [] synonym: "mannitol biosynthesis" EXACT [] synonym: "mannitol formation" EXACT [] synonym: "mannitol synthesis" EXACT [] xref: MetaCyc:PWY-3881 is_a: GO:0019406 ! hexitol biosynthetic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019594 name: mannitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019595 name: non-phosphorylated glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai] synonym: "non-phosphorylated glucose breakdown" EXACT [] synonym: "non-phosphorylated glucose catabolism" EXACT [] synonym: "non-phosphorylated glucose degradation" EXACT [] xref: MetaCyc:NPGLUCAT-PWY is_a: GO:0006007 ! glucose catabolic process is_a: GO:0046430 ! non-phosphorylated glucose metabolic process [Term] id: GO:0019596 name: mandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators] synonym: "mandelate breakdown" EXACT [] synonym: "mandelate catabolism" EXACT [] synonym: "mandelate degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019597 name: (R)-mandelate catabolic process to benzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] synonym: "(R)-mandelate breakdown to benzoate" EXACT [] synonym: "(R)-mandelate degradation to benzoate" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019596 ! mandelate catabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0019598 name: (R)-mandelate catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators] synonym: "(R)-mandelate breakdown to catechol" EXACT [] synonym: "(R)-mandelate degradation to catechol" EXACT [] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0019596 ! mandelate catabolic process [Term] id: GO:0019599 name: (R)-4-hydroxymandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai] synonym: "(R)-4-hydroxymandelate breakdown" EXACT [] synonym: "(R)-4-hydroxymandelate catabolism" EXACT [] synonym: "(R)-4-hydroxymandelate degradation" EXACT [] xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019600 name: toluene oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019601 name: toluene oxidation via 2-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY] xref: MetaCyc:TOLUENE-DEG-2-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019602 name: toluene oxidation via 3-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY] xref: MetaCyc:TOLUENE-DEG-3-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019603 name: toluene oxidation via 4-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY] xref: MetaCyc:TOLUENE-DEG-4-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019604 name: toluene oxidation to catechol namespace: biological_process def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY] xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY xref: UM-BBD_pathwayID:tol is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019605 name: butyrate metabolic process namespace: biological_process alt_id: GO:0043437 def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732] synonym: "butanoic acid metabolic process" EXACT [] synonym: "butanoic acid metabolism" EXACT [] synonym: "butyrate metabolism" EXACT [] synonym: "butyric acid metabolic process" EXACT [] synonym: "butyric acid metabolism" EXACT [] is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019606 name: 2-oxobutyrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732] synonym: "2-oxobutyrate breakdown" EXACT [] synonym: "2-oxobutyrate catabolism" EXACT [] synonym: "2-oxobutyrate degradation" EXACT [] synonym: "alpha-ketobutyrate catabolic process" EXACT [] synonym: "alpha-ketobutyrate catabolism" EXACT [] xref: MetaCyc:2OXOBUTYRATECAT-PWY is_a: GO:0019626 ! short-chain fatty acid catabolic process is_a: GO:0046361 ! 2-oxobutyrate metabolic process [Term] id: GO:0019607 name: phenylethylamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine breakdown" EXACT [] synonym: "phenylethylamine catabolism" EXACT [] synonym: "phenylethylamine degradation" EXACT [] xref: MetaCyc:2PHENDEG-PWY is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042443 ! phenylethylamine metabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0019608 name: nicotine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine breakdown" EXACT [] synonym: "nicotine catabolism" EXACT [] synonym: "nicotine degradation" EXACT [] xref: MetaCyc:P181-PWY xref: UM-BBD_pathwayID:nic is_a: GO:0018933 ! nicotine metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019609 name: 3-hydroxyphenylacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] synonym: "3-hydroxyphenylacetate metabolism" EXACT [] synonym: "3HPA metabolic process" EXACT [] synonym: "3HPA metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019610 name: 3-hydroxyphenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] synonym: "3-hydroxyphenylacetate breakdown" EXACT [] synonym: "3-hydroxyphenylacetate catabolism" EXACT [] synonym: "3-hydroxyphenylacetate degradation" EXACT [] xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019611 name: 4-toluenecarboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] synonym: "4-toluenecarboxylate metabolism" EXACT [] synonym: "p-toluate metabolic process" EXACT [] synonym: "p-toluate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0019612 name: 4-toluenecarboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] synonym: "4-toluenecarboxylate breakdown" EXACT [] synonym: "4-toluenecarboxylate catabolism" EXACT [] synonym: "4-toluenecarboxylate degradation" EXACT [] synonym: "p-toluate catabolic process" EXACT [] synonym: "p-toluate catabolism" EXACT [] xref: MetaCyc:4TOLCARBDEG-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019614 name: catechol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol breakdown" RELATED [] synonym: "catechol catabolic process" RELATED [] synonym: "catechol catabolism" RELATED [] synonym: "catechol degradation" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0019615 name: catechol catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/] synonym: "catechol breakdown, ortho-cleavage" EXACT [] synonym: "catechol degradation, ortho-cleavage" EXACT [] xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY xref: MIPS_funcat:01.05.01.01.09.01 is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042952 ! beta-ketoadipate pathway [Term] id: GO:0019616 name: catechol catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/] synonym: "catechol breakdown, meta-cleavage" EXACT [] synonym: "catechol degradation, meta-cleavage" EXACT [] xref: MetaCyc:P183-PWY xref: MIPS_funcat:01.05.01.01.09.03 is_a: GO:0019614 ! catechol-containing compound catabolic process [Term] id: GO:0019617 name: protocatechuate catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY] synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED [] synonym: "protocatechuate breakdown, meta-cleavage" EXACT [] synonym: "protocatechuate catabolic process to oxaloacetate and pyruvate" EXACT [] synonym: "protocatechuate degradation, meta-cleavage" EXACT [] xref: MetaCyc:P184-PWY xref: MIPS_funcat:01.05.01.01.09.03 is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process [Term] id: GO:0019618 name: protocatechuate catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY] synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT [] synonym: "protocatechuate breakdown, ortho-cleavage" EXACT [] synonym: "protocatechuate catabolic process to beta-ketoadipate" EXACT [] synonym: "protocatechuate degradation, ortho-cleavage" EXACT [] xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY xref: MIPS_funcat:01.05.01.01.09.01 is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0019619 name: 3,4-dihydroxybenzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." [GOC:ai] synonym: "protocatechuate breakdown" EXACT [] synonym: "protocatechuate catabolic process" EXACT [] synonym: "protocatechuate catabolism" EXACT [] synonym: "protocatechuate degradation" EXACT [] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019620 name: aerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai] synonym: "aerobic benzoate metabolism" EXACT [] is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0019621 name: creatinine catabolic process to formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators] synonym: "creatinine breakdown to formate" EXACT [] synonym: "creatinine degradation to formate" EXACT [] xref: MetaCyc:CRNFORCAT-PWY is_a: GO:0006602 ! creatinine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019622 name: 3-(3-hydroxy)phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019623 name: atrazine catabolic process to urea namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl] synonym: "atrazine breakdown to urea" EXACT [] synonym: "atrazine degradation to urea" EXACT [] is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0019627 ! urea metabolic process [Term] id: GO:0019624 name: atrazine catabolic process to isopropylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl] synonym: "atrazine breakdown to isopropylamine" EXACT [] synonym: "atrazine degradation to isopropylamine" EXACT [] is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0019625 name: atrazine catabolic process to cyanuric acid namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl] synonym: "atrazine breakdown to cyanuric acid" EXACT [] synonym: "atrazine degradation to cyanuric acid" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0042199 ! cyanuric acid metabolic process [Term] id: GO:0019626 name: short-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6." [ISBN:0198506732] synonym: "short-chain fatty acid breakdown" EXACT [] synonym: "short-chain fatty acid catabolism" EXACT [] synonym: "short-chain fatty acid degradation" EXACT [] xref: MetaCyc:ACETOACETATE-DEG-PWY is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019627 name: urea metabolic process namespace: biological_process def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732] synonym: "urea metabolism" EXACT [] xref: MIPS_funcat:01.01.05 xref: MIPS_funcat:01.01.05.03 is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071941 ! nitrogen cycle metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019628 name: urate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732] synonym: "urate breakdown" EXACT [] synonym: "urate catabolism" EXACT [] synonym: "urate degradation" EXACT [] synonym: "uric acid catabolic process" EXACT [] xref: MetaCyc:P165-PWY xref: MIPS_funcat:01.02.01.09.03 is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046415 ! urate metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0019629 name: propionate catabolic process, 2-methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators] synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT [] synonym: "propionate degradation, 2-methylcitrate cycle" EXACT [] is_a: GO:0019543 ! propionate catabolic process [Term] id: GO:0019630 name: quinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732] synonym: "quinate metabolism" EXACT [] synonym: "quinic acid metabolic process" EXACT [] synonym: "quinic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0019631 name: quinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl] synonym: "quinate breakdown" EXACT [] synonym: "quinate catabolism" EXACT [] synonym: "quinate degradation" EXACT [] synonym: "quinic acid catabolic process" EXACT [] synonym: "quinic acid catabolism" EXACT [] xref: MetaCyc:QUINATEDEG-PWY is_a: GO:0019630 ! quinate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019632 name: shikimate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:sm, ISBN:0198547684] synonym: "shikimate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0019633 name: shikimate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [GOC:go_curators] synonym: "shikimate breakdown" EXACT [] synonym: "shikimate catabolism" EXACT [] synonym: "shikimate degradation" EXACT [] xref: MetaCyc:SHIKIMATEDEG-PWY is_a: GO:0019632 ! shikimate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019634 name: organic phosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544] synonym: "organophosphonate metabolic process" RELATED [] synonym: "phosphonate metabolism" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0019635 name: 2-aminoethylphosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai] synonym: "2-aminoethylphosphonate breakdown" EXACT [] synonym: "2-aminoethylphosphonate catabolism" EXACT [] synonym: "2-aminoethylphosphonate degradation" EXACT [] synonym: "2-phosphonoethylamine catabolic process" EXACT [] synonym: "2-phosphonoethylamine catabolism" EXACT [] synonym: "ciliatine catabolic process" EXACT [] synonym: "ciliatine catabolism" EXACT [] xref: MetaCyc:PHOSPHONOTASE-PWY is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0019636 name: phosphonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY] synonym: "phosphonoacetate metabolism" EXACT [] xref: MetaCyc:P483-PWY is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] synonym: "organophosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019638 name: 6-hydroxycineole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] synonym: "6-endo-hydroxycineole metabolic process" EXACT [] synonym: "6-endo-hydroxycineole metabolism" EXACT [] synonym: "6-hydroxycineole metabolism" EXACT [] synonym: "hydroxycineol metabolic process" EXACT [] synonym: "hydroxycineol metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0097176 ! epoxide metabolic process [Term] id: GO:0019639 name: 6-hydroxycineole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] synonym: "6-endo-hydroxycineole catabolic process" EXACT [] synonym: "6-endo-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole breakdown" EXACT [] synonym: "6-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole degradation" EXACT [] synonym: "hydroxycineol catabolic process" EXACT [] synonym: "hydroxycineol catabolism" EXACT [] xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0019638 ! 6-hydroxycineole metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0019640 name: glucuronate catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators] synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT [] synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT [] is_a: GO:0006064 ! glucuronate catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019643 name: reductive tricarboxylic acid cycle namespace: biological_process alt_id: GO:0019644 def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028] synonym: "reductive carboxylate cycle" EXACT [] synonym: "reductive carboxylic acid cycle" EXACT [] synonym: "reductive citric acid pathway" EXACT [] synonym: "reductive Kreb's cycle" EXACT [] synonym: "reductive TCA cycle" EXACT [] xref: MetaCyc:P23-PWY xref: MetaCyc:REDCITCYC xref: MIPS_funcat:01.05.01.05.03 is_a: GO:0006099 ! tricarboxylic acid cycle is_a: GO:0015977 ! carbon fixation [Term] id: GO:0019645 name: anaerobic electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0009061 ! anaerobic respiration [Term] id: GO:0019646 name: aerobic electron transport chain namespace: biological_process alt_id: GO:0006136 alt_id: GO:0006137 alt_id: GO:0006138 def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] synonym: "NADH-O2 electron transport" NARROW [] synonym: "succinate-O2 electron transport" NARROW [] synonym: "ubiquinone-8-O2 electron transport" NARROW [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0019647 name: formaldehyde assimilation via ribulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861] synonym: "formaldehyde assimilation via RuMP cycle" EXACT [] synonym: "ribulose monophosphate cycle" BROAD [] xref: MetaCyc:PWY-1861 xref: MIPS_funcat:01.05.01.01.05.03 is_a: GO:0019649 ! formaldehyde assimilation [Term] id: GO:0019648 name: formaldehyde assimilation via xylulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY] synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT [] synonym: "formaldehyde fixation cycle" EXACT [] xref: MetaCyc:P185-PWY is_a: GO:0019649 ! formaldehyde assimilation is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019649 name: formaldehyde assimilation namespace: biological_process def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai] is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0019650 name: glycolytic fermentation to butanediol namespace: biological_process alt_id: GO:0030646 def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [GOC:dph, GOC:nr, ISBN:0198506732] synonym: "butanediol fermentation" EXACT [] synonym: "glucose catabolic process to butanediol" EXACT [GOC:dph] synonym: "glucose fermentation to butanediol" EXACT [] xref: MetaCyc:P125-PWY xref: MIPS_funcat:02.16.09 xref: Wikipedia:Butanediol_fermentation is_a: GO:0019660 ! glycolytic fermentation relationship: has_part GO:0003984 ! acetolactate synthase activity relationship: has_part GO:0047605 ! acetolactate decarboxylase activity relationship: has_part GO:0052587 ! diacetyl reductase ((R)-acetoin forming) activity [Term] id: GO:0019651 name: citrate catabolic process to diacetyl namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] synonym: "citrate fermentation to diacetyl" EXACT [] synonym: "diacetyl fermentation" EXACT [] is_a: GO:0006101 ! citrate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019662 ! non-glycolytic fermentation is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process [Term] id: GO:0019652 name: lactate fermentation to propionate and acetate namespace: biological_process def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY] synonym: "acrylate pathway" EXACT [] synonym: "nonrandomizing pathway" EXACT [] synonym: "propionate fermentation" EXACT [] xref: MetaCyc:PROPFERM-PWY xref: MIPS_funcat:02.16.11 xref: MIPS_funcat:02.16.11.01 is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019653 name: anaerobic purine nucleobase catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP." [GOC:mah] synonym: "anaerobic purine base catabolic process" EXACT [GOC:go_curators] synonym: "anaerobic purine base catabolism" EXACT [] synonym: "anaerobic purine catabolic process" RELATED [] synonym: "purine base fermentation" EXACT [] synonym: "purine fermentation" RELATED [] xref: MetaCyc:P164-PWY xref: MetaCyc:PWY-5044 xref: MetaCyc:PWY-5497 xref: MIPS_funcat:02.16.17.05 is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0019654 name: acetate fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [GOC:jl, MetaCyc:P142-PWY] xref: MetaCyc:P142-PWY xref: MIPS_funcat:02.16.13 is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019655 name: glycolytic fermentation to ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [GOC:dph, GOC:nr, ISBN:0716720094] synonym: "alcoholic fermentation" RELATED [ISBN:0716720094] synonym: "ethanol fermentation" EXACT [] synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph] synonym: "glucose fermentation to ethanol" EXACT [] xref: Wikipedia:Ethanol_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019656 name: glucose catabolic process to D-lactate and ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY] synonym: "glucose fermentation to D-lactate and ethanol" EXACT [] synonym: "heterofermentation" EXACT [] synonym: "heterofermentative lactate fermentation" EXACT [] synonym: "heterofermentative pathway" EXACT [] synonym: "heterolactate fermentation" EXACT [] synonym: "heterolactic fermentation" EXACT [] xref: MetaCyc:P122-PWY xref: MIPS_funcat:02.16.03.03 is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019662 ! non-glycolytic fermentation is_a: GO:1902707 ! hexose catabolic process to ethanol [Term] id: GO:0019657 name: glycolytic fermentation to propionate namespace: biological_process def: "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [GOC:dph, GOC:nr, MetaCyc:P108-PWY] synonym: "succinate-propionate fermentation" EXACT [] xref: MetaCyc:P108-PWY xref: MIPS_funcat:02.16.11.03 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0042867 ! pyruvate catabolic process relationship: has_part GO:0043821 ! propionyl-CoA:succinate CoA-transferase activity relationship: has_part GO:0047154 ! methylmalonyl-CoA carboxytransferase activity [Term] id: GO:0019658 name: glucose fermentation to lactate and acetate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY] synonym: "bifidum pathway" EXACT [] synonym: "glucose catabolic process to lactate and acetate" BROAD [] xref: MetaCyc:P124-PWY xref: MIPS_funcat:02.16.03.05 is_a: GO:0006007 ! glucose catabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019659 name: glucose catabolic process to lactate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] synonym: "glucose fermentation to lactate" EXACT [] synonym: "lactate fermentation" EXACT [] xref: MIPS_funcat:02.16.03 xref: Wikipedia:Lactic_acid_fermentation is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019660 name: glycolytic fermentation namespace: biological_process def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators] xref: MetaCyc:Pyruvate-Degredation is_a: GO:0006113 ! fermentation is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0019661 name: glucose catabolic process to lactate via pyruvate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] synonym: "glucose fermentation to lactate via pyruvate" EXACT [] synonym: "homofermentation" EXACT [] synonym: "homofermentative lactate fermentation" EXACT [] synonym: "homofermentative pathway" EXACT [] synonym: "homolactate fermentation" EXACT [] synonym: "homolactic fermentation" EXACT [ISBN:0716720094] xref: MetaCyc:ANAEROFRUCAT-PWY xref: MIPS_funcat:02.16.03.01 is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0019662 name: non-glycolytic fermentation namespace: biological_process def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] is_a: GO:0006113 ! fermentation [Term] id: GO:0019664 name: mixed acid fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [ISBN:0716720094, MetaCyc:FERMENTATION-PWY] synonym: "glucose catabolic process to mixed acids" BROAD [] synonym: "glucose fermentation to mixed acids" EXACT [] xref: MIPS_funcat:02.16.09 xref: Wikipedia:Mixed_acid_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019665 name: anaerobic amino acid catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] synonym: "amino acid fermentation" EXACT [] xref: MIPS_funcat:02.16.17.01 is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0019666 name: nitrogenous compound fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah] synonym: "nitrogenous compound catabolic process" BROAD [] xref: MIPS_funcat:02.16.17 is_a: GO:0006113 ! fermentation is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0019667 name: anaerobic L-alanine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl] synonym: "L-alanine fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019668 name: anaerobic catabolism of pairs of amino acids namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081] synonym: "cofermentation of pairs of amino acids" EXACT [] synonym: "Stickland reaction" NARROW [] xref: MIPS_funcat:02.16.17.03 is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019669 name: anaerobic glycine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl] synonym: "glycine fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019670 name: anaerobic glutamate catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl] synonym: "glutamate fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019671 name: glutamate catabolic process via mesaconate and citramalate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY] synonym: "glutamate fermentation via mesaconate and citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY xref: MetaCyc:PWY-5087 xref: MetaCyc:PWY-5088 is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019672 name: ethanol-acetate fermentation to butyrate and caproate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] xref: MIPS_funcat:02.16.07 is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019673 name: GDP-mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-mannose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019674 name: NAD metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) metabolic process" EXACT [] synonym: "NAD (oxidized) metabolism" EXACT [] synonym: "NAD metabolism" EXACT [] synonym: "NAD phosphorylation and dephosphorylation" NARROW [] synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide metabolism" EXACT [] synonym: "oxidized NAD metabolic process" EXACT [] synonym: "oxidized NAD metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0019675 name: obsolete NAD phosphorylation and dephosphorylation namespace: biological_process def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist. synonym: "NAD phosphorylation and dephosphorylation" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT [] is_obsolete: true consider: GO:0006739 consider: GO:0019674 [Term] id: GO:0019676 name: ammonia assimilation cycle namespace: biological_process def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY] synonym: "glutamate metabolic process via glutamine and ammonia" EXACT [] synonym: "glutamate metabolism via glutamine and ammonia" EXACT [] xref: MetaCyc:AMMASSIM-PWY xref: MetaCyc:PWY-3282 xref: MIPS_funcat:01.02.01.06 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0019740 ! nitrogen utilization [Term] id: GO:0019677 name: NAD catabolic process namespace: biological_process alt_id: GO:0006737 def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) catabolic process" EXACT [] synonym: "NAD (oxidized) catabolism" EXACT [] synonym: "NAD (reduced) catabolic process" EXACT [] synonym: "NAD (reduced) catabolism" EXACT [] synonym: "NAD breakdown" EXACT [] synonym: "NAD catabolism" EXACT [] synonym: "NAD degradation" EXACT [] synonym: "NADH catabolic process" EXACT [] synonym: "NADH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "oxidized NAD catabolic process" EXACT [] synonym: "oxidized NAD catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "reduced NAD catabolic process" EXACT [] synonym: "reduced NAD catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT [] is_a: GO:0019364 ! pyridine nucleotide catabolic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019678 name: propionate metabolic process, methylmalonyl pathway namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators] synonym: "propionate metabolism, methylmalonyl pathway" EXACT [] xref: MetaCyc:PROPIONMET-PWY is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019679 name: propionate metabolic process, methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators] synonym: "propionate metabolism, methylcitrate cycle" EXACT [] xref: MetaCyc:PWY0-42 is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019680 name: L-methylmalonyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-methylmalonyl-CoA anabolism" EXACT [] synonym: "L-methylmalonyl-CoA biosynthesis" EXACT [] synonym: "L-methylmalonyl-CoA formation" EXACT [] synonym: "L-methylmalonyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY0-43 is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0019681 name: acetyl-CoA assimilation pathway namespace: biological_process def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY] synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0046356 ! acetyl-CoA catabolic process [Term] id: GO:0019682 name: glyceraldehyde-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732] synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate metabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019683 name: glyceraldehyde-3-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732] synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate breakdown" EXACT [] synonym: "glyceraldehyde-3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate degradation" EXACT [] is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0019684 name: photosynthesis, light reaction namespace: biological_process def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org] synonym: "photolysis" RELATED [] xref: MetaCyc:PWY-101 xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019685 name: photosynthesis, dark reaction namespace: biological_process def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952] is_a: GO:0016051 ! carbohydrate biosynthetic process relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019686 name: purine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0015949 ! nucleobase-containing small molecule interconversion is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0019687 name: pyruvate biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators] synonym: "pyruvate anabolism from acetate" EXACT [] synonym: "pyruvate formation from acetate" EXACT [] synonym: "pyruvate synthesis from acetate" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0042866 ! pyruvate biosynthetic process [Term] id: GO:0019688 name: purine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0019686 ! purine nucleoside interconversion is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0019689 name: pyrimidine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0019690 name: pyrimidine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0019689 ! pyrimidine nucleoside interconversion is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0019692 name: deoxyribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] synonym: "deoxyribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019694 name: alkanesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] synonym: "alkanesulfonate metabolism" EXACT [] synonym: "alkanesulphonate metabolic process" EXACT [] synonym: "alkanesulphonate metabolism" EXACT [] xref: MetaCyc:ALKANEMONOX-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019695 name: choline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] synonym: "choline metabolism" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0071704 ! organic substance metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0019696 name: toluene oxidation via toluene-cis-1,2-dihydrodiol namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY] xref: MetaCyc:TOLUENE-DEG-DIOL-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019697 name: L-xylitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051160 ! L-xylitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019698 name: D-galacturonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-galacturonate breakdown" EXACT [] synonym: "D-galacturonate catabolism" EXACT [] synonym: "D-galacturonate degradation" EXACT [] xref: MetaCyc:GALACTUROCAT-PWY is_a: GO:0046396 ! D-galacturonate metabolic process is_a: GO:0046397 ! galacturonate catabolic process [Term] id: GO:0019700 name: organic phosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] synonym: "organophosphonate catabolic process" RELATED [] synonym: "phosphonate breakdown" EXACT [] synonym: "phosphonate catabolism" EXACT [] synonym: "phosphonate degradation" EXACT [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0019701 name: peptidyl-arginine N5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305] synonym: "peptidyl-arginine delta-N-methylation" EXACT [] xref: RESID:AA0305 is_a: GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0019702 name: protein-arginine N5-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine." [EC:2.1.1.322, PMID:9873020] comment: This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. synonym: "protein-arginine delta-N-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)" EXACT [EC:2.1.1.322] synonym: "type IV PRMT activity" EXACT [] synonym: "type IV protein arginine methyltransferase activity" EXACT [] xref: EC:2.1.1.322 xref: RHEA:48116 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0019703 name: coenzyme A-peptidyl-cysteine covalent linking namespace: biological_process def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306] xref: RESID:AA0306 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019704 name: peptidyl-L-cysteine S-myristoylation namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307] synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0307 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0019705 name: protein-cysteine S-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to a sulfur atom on a cysteine residue of a protein molecule." [GOC:ai] is_a: GO:0019107 ! myristoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019706 name: protein-cysteine S-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr] synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED [] xref: EC:2.3.1.225 xref: Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer" xref: Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1" is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019707 name: protein-cysteine S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019708 name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine namespace: biological_process def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309] synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0309 is_a: GO:0006501 ! C-terminal protein lipidation is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0019709 name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide namespace: biological_process def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] xref: RESID:AA0310 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0019710 name: peptidyl-asparagine methylation namespace: biological_process alt_id: GO:0018018 def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311] xref: RESID:AA0070 xref: RESID:AA0311 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0019711 name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators] synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019712 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT [] xref: RESID:AA0072 is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine [Term] id: GO:0019713 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine namespace: biological_process def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine is_a: GO:0019714 ! peptidyl-glutamine esterification [Term] id: GO:0019714 name: peptidyl-glutamine esterification namespace: biological_process def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah] is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0019715 name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid namespace: biological_process def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. xref: RESID:AA0027 is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation [Term] id: GO:0019716 name: N-terminal peptidyl-alanine monomethylation namespace: biological_process def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061] xref: RESID:AA0061 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0019717 name: obsolete synaptosome namespace: cellular_component def: "OBSOLETE. Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732] comment: This term was made obsolete because it refers to a result of cell homogenization and not a bona fide cellular component. synonym: "synaptosome" EXACT [] xref: Wikipedia:Synaptosome is_obsolete: true consider: GO:0043005 [Term] id: GO:0019718 name: obsolete rough microsome namespace: cellular_component def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "rough microsome" EXACT [] is_obsolete: true consider: GO:0005791 [Term] id: GO:0019719 name: obsolete smooth microsome namespace: cellular_component def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "smooth microsome" EXACT [] is_obsolete: true consider: GO:0005790 [Term] id: GO:0019720 name: Mo-molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] synonym: "Mo-molybdopterin cofactor metabolism" EXACT [] synonym: "Moco metabolic process" BROAD [] synonym: "Moco metabolism" BROAD [] is_a: GO:0043545 ! molybdopterin cofactor metabolic process [Term] id: GO:0019722 name: calcium-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] synonym: "calcium ion signaling" EXACT [] synonym: "calcium signaling" EXACT [] synonym: "calcium signalling" EXACT [] synonym: "calcium-mediated signalling" EXACT [] xref: MIPS_funcat:30.01.09.03 xref: Wikipedia:Calcium_signaling is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019724 name: B cell mediated immunity namespace: biological_process def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "B lymphocyte mediated immune effector process" EXACT [] synonym: "B lymphocyte mediated immunity" EXACT [] synonym: "B-cell mediated immune effector process" EXACT [] synonym: "B-cell mediated immunity" EXACT [] synonym: "B-lymphocyte mediated immune effector process" EXACT [] synonym: "B-lymphocyte mediated immunity" EXACT [] xref: MIPS_funcat:36.25.16.03.01 is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant is_a: GO:0009987 ! cellular process is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell [Term] id: GO:0019726 name: mevaldate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20193] synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33] synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33] xref: EC:1.1.1.33 xref: KEGG_REACTION:R02247 xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN xref: RHEA:20193 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019727 name: mevaldate reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH." [EC:1.1.1.32, RHEA:13221] xref: EC:1.1.1.32 xref: KEGG_REACTION:R02246 xref: MetaCyc:MEVALDATE-REDUCTASE-RXN xref: RHEA:13221 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019728 name: peptidyl-allysine oxidation to 2-aminoadipic acid namespace: biological_process def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122] xref: RESID:AA0370 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019729 name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0189 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019730 name: antimicrobial humoral response namespace: biological_process alt_id: GO:0006960 alt_id: GO:0019735 def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0006959 ! humoral immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0019731 name: antibacterial humoral response namespace: biological_process alt_id: GO:0006961 alt_id: GO:0019733 def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0019732 name: antifungal humoral response namespace: biological_process alt_id: GO:0006966 alt_id: GO:0019734 def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0019736 name: peptidyl-sarcosine incorporation namespace: biological_process def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063] xref: RESID:AA0063 is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0019740 name: nitrogen utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] xref: MIPS_funcat:01.02.01 is_a: GO:0008150 ! biological_process relationship: has_part GO:0006807 ! nitrogen compound metabolic process relationship: has_part GO:0071705 ! nitrogen compound transport [Term] id: GO:0019741 name: pentacyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid breakdown" EXACT [] synonym: "pentacyclic triterpenoid catabolism" EXACT [] synonym: "pentacyclic triterpenoid degradation" EXACT [] is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019742 name: pentacyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid metabolism" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0019743 name: hopanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid breakdown" EXACT [] synonym: "hopanoid catabolism" EXACT [] synonym: "hopanoid degradation" EXACT [] is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0019744 ! hopanoid metabolic process [Term] id: GO:0019744 name: hopanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid metabolism" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process [Term] id: GO:0019745 name: pentacyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid anabolism" EXACT [] synonym: "pentacyclic triterpenoid biosynthesis" EXACT [] synonym: "pentacyclic triterpenoid formation" EXACT [] synonym: "pentacyclic triterpenoid synthesis" EXACT [] is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0019746 name: hopanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid anabolism" EXACT [] synonym: "hopanoid biosynthesis" EXACT [] synonym: "hopanoid formation" EXACT [] synonym: "hopanoid synthesis" EXACT [] xref: MIPS_funcat:01.06.01.07.11 is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:0019744 ! hopanoid metabolic process [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] synonym: "regulation of isoprenoid metabolism" EXACT [] xref: MIPS_funcat:01.06.10 is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006720 ! isoprenoid metabolic process relationship: regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: MIPS_funcat:01.20 xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019749 name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport intersection_of: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte intersection_of: GO:0030705 ! cytoskeleton-dependent intracellular transport [Term] id: GO:0019750 name: chloroplast localization namespace: biological_process def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "chloroplast localisation" EXACT [GOC:mah] xref: MIPS_funcat:20.09.02 is_a: GO:0051644 ! plastid localization [Term] id: GO:0019751 name: polyol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188] synonym: "polyhydric alcohol metabolic process" EXACT [] synonym: "polyol metabolism" EXACT [] xref: MIPS_funcat:01.05.01.01.01 is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] xref: MIPS_funcat:01.05.01.01.01 is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0019756 name: cyanogenic glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] synonym: "cyanogenic glycoside anabolism" EXACT [] synonym: "cyanogenic glycoside biosynthesis" EXACT [] synonym: "cyanogenic glycoside formation" EXACT [] synonym: "cyanogenic glycoside synthesis" EXACT [] xref: MIPS_funcat:01.20.17.05 is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0042341 ! cyanogenic glycoside metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0080028 ! nitrile biosynthetic process [Term] id: GO:0019757 name: glycosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate metabolism" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019758 name: glycosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate anabolism" EXACT [] synonym: "glycosinolate biosynthesis" EXACT [] synonym: "glycosinolate formation" EXACT [] synonym: "glycosinolate synthesis" EXACT [] xref: MIPS_funcat:01.20.17.07 is_a: GO:0016144 ! S-glycoside biosynthetic process is_a: GO:0019757 ! glycosinolate metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019759 name: glycosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate breakdown" EXACT [] synonym: "glycosinolate catabolism" EXACT [] synonym: "glycosinolate degradation" EXACT [] is_a: GO:0016145 ! S-glycoside catabolic process is_a: GO:0019757 ! glycosinolate metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019760 name: glucosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [GOC:curators] synonym: "glucosinolate metabolism" EXACT [] is_a: GO:0019757 ! glycosinolate metabolic process [Term] id: GO:0019761 name: glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] synonym: "glucosinolate anabolism" EXACT [] synonym: "glucosinolate biosynthesis" EXACT [] synonym: "glucosinolate formation" EXACT [] synonym: "glucosinolate synthesis" EXACT [] is_a: GO:0019758 ! glycosinolate biosynthetic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019762 name: glucosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] synonym: "glucosinolate breakdown" EXACT [] synonym: "glucosinolate catabolism" EXACT [] synonym: "glucosinolate degradation" EXACT [] xref: MetaCyc:PWY-5267 is_a: GO:0019759 ! glycosinolate catabolic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019763 name: immunoglobulin receptor activity namespace: molecular_function alt_id: GO:0016489 def: "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, ISBN:0198547684] synonym: "FC receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0019865 ! immunoglobulin binding relationship: part_of GO:0038093 ! Fc receptor signaling pathway [Term] id: GO:0019764 name: obsolete high affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is an unnecessary grouping term. synonym: "high affinity Fc receptor activity" EXACT [] is_obsolete: true consider: GO:0019768 consider: GO:0019771 [Term] id: GO:0019765 name: obsolete low affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is undefined and is an unnecessary grouping term. synonym: "low affinity Fc receptor activity" EXACT [] is_obsolete: true consider: GO:0019769 consider: GO:0019772 [Term] id: GO:0019766 name: IgA receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity relationship: has_part GO:0019862 ! IgA binding [Term] id: GO:0019767 name: IgE receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity relationship: has_part GO:0019863 ! IgE binding relationship: part_of GO:0038095 ! Fc-epsilon receptor signaling pathway [Term] id: GO:0019768 name: high-affinity IgE receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "high affinity Fc receptor activity" RELATED [] synonym: "high affinity IgE receptor activity" EXACT [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019769 name: low-affinity IgE receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "low affinity Fc receptor activity" RELATED [] synonym: "low affinity IgE receptor activity" EXACT [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019770 name: IgG receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity relationship: has_part GO:0019864 ! IgG binding relationship: part_of GO:0038094 ! Fc-gamma receptor signaling pathway [Term] id: GO:0019771 name: high-affinity IgG receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "high affinity Fc receptor activity" RELATED [] synonym: "high affinity IgG receptor activity" EXACT [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019772 name: low-affinity IgG receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "low affinity Fc receptor activity" RELATED [] synonym: "low affinity IgG receptor activity" EXACT [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019773 name: proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019774 name: proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019775 name: FAT10 transferase activity namespace: molecular_function def: "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages." [GOC:dph, GOC:mah, PMID:12826404] synonym: "FAT10 conjugating enzyme activity" NARROW [] is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019776 name: Atg8 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] synonym: "APG8 conjugating enzyme activity" EXACT [] synonym: "APG8 ligase activity" EXACT [] synonym: "Atg8 conjugating enzyme activity" EXACT [] xref: Reactome:R-HSA-5681981 "ATG3 transfers LC3 from ATG7 to ATG3" is_a: GO:0016740 ! transferase activity [Term] id: GO:0019777 name: Atg12 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" NARROW [] synonym: "APG12 ligase activity" NARROW [] synonym: "Atg12 conjugating enzyme activity" NARROW [] synonym: "Atg12 ligase activity" NARROW [] xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019778 name: Atg12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019779 name: Atg8 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG7" EXACT [] synonym: "APG8 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019780 name: FAT10 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019781 name: NEDD8 activating enzyme activity namespace: molecular_function alt_id: GO:0019944 def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] synonym: "RUB1 activating enzyme activity" EXACT [] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019782 name: ISG15 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "UBE1L" NARROW [] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019783 name: ubiquitin-like protein-specific protease activity namespace: molecular_function alt_id: GO:1904454 alt_id: GO:1904455 def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph] synonym: "ubiquitin-like specific protease activity" NARROW [] synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] synonym: "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway" NARROW [] synonym: "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway" NARROW [] is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0019784 name: NEDD8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] synonym: "deneddylase activity" EXACT [GOC:dph] xref: Reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8" xref: Reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2" xref: Reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes" xref: Reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex" is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019785 name: ISG15-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] xref: Reactome:R-HSA-1678841 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18" xref: Reactome:R-HSA-5653786 "USP43 deISGylates ISG:K164,ISG:K168-PCNA" is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019786 name: Atg8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] synonym: "APG8-PE hydrolase" RELATED [] synonym: "APG8-specific protease activity" RELATED [GOC:vw] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019787 name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: goslim_drosophila subset: goslim_pir synonym: "E2" RELATED [] synonym: "E3" RELATED [dph:GOC] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" is_a: GO:0016740 ! transferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019788 name: NEDD8 transferase activity namespace: molecular_function alt_id: GO:0016976 alt_id: GO:0019945 alt_id: GO:0042295 def: "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] synonym: "Hub1 conjugating enzyme activity" RELATED [] synonym: "NEDD8 conjugating enzyme activity" RELATED [] synonym: "RUB1 conjugating enzyme activity" RELATED [] xref: Reactome:R-HSA-8951648 "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1" xref: Reactome:R-HSA-8951661 "Transfer of NEDD8 to AcM-UBE2M" xref: Reactome:R-HSA-8951764 "Transfer of NEDD8 to AcM-UBE2F" xref: Reactome:R-HSA-8952044 "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex" xref: Reactome:R-HSA-8952618 "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex" xref: Reactome:R-HSA-8952638 "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex" xref: Reactome:R-HSA-8956025 "AcM-UBE2M transfers NEDD8 to CUL9:RBX1" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019789 name: SUMO transferase activity namespace: molecular_function alt_id: GO:0016930 alt_id: GO:0019949 def: "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] synonym: "SMT3 conjugating enzyme" RELATED [] synonym: "SUMO conjugating enzyme activity" RELATED [] xref: Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)" xref: Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)" xref: Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)" xref: Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3" xref: Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3" xref: Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1" xref: Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1" xref: Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2" xref: Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1" xref: Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1" xref: Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2" xref: Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3" xref: Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1" xref: Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3" xref: Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1" xref: Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1" xref: Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1" xref: Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1" xref: Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1" xref: Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1" xref: Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1" xref: Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1" xref: Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3" xref: Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1" xref: Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1" xref: Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1" xref: Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1" xref: Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1" xref: Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2" xref: Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1" xref: Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1" xref: Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1" xref: Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1" xref: Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1" xref: Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1" xref: Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1" xref: Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1" xref: Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1" xref: Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1" xref: Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1" xref: Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3" xref: Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1" xref: Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1" xref: Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1" xref: Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3" xref: Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1" xref: Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1" xref: Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1" xref: Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1" xref: Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1" xref: Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1" xref: Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1" xref: Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1" xref: Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1" xref: Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1" xref: Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1" xref: Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2" xref: Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1" xref: Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2" xref: Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1" xref: Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2" xref: Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1" xref: Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3" xref: Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1" xref: Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1" xref: Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1" xref: Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1" xref: Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2" xref: Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1" xref: Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1" xref: Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1" xref: Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1" xref: Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3" xref: Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3" xref: Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1" xref: Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1" xref: Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1" xref: Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3" xref: Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3" xref: Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1" xref: Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3" xref: Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2" xref: Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1" xref: Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1" xref: Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2" xref: Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1" xref: Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3" xref: Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1" xref: Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3" xref: Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1" xref: Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1" xref: Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1" xref: Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3" xref: Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1" xref: Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1" xref: Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1" xref: Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3" xref: Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1" xref: Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1" xref: Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1" xref: Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3" xref: Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1" xref: Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)" xref: Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1" xref: Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1" xref: Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1" xref: Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1" xref: Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1" xref: Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)" xref: Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2" xref: Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3" xref: Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1." xref: Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1" xref: Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1" xref: Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3" xref: Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3" xref: Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3" xref: Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1" xref: Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1" xref: Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1" xref: Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1" xref: Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3" xref: Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3" xref: Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1" xref: Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1" xref: Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1" xref: Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1" xref: Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs" xref: Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1" xref: Reactome:R-HSA-6790454 "SUMOylation of XPC" xref: Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2" xref: Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2" xref: Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1" is_a: GO:0019787 ! ubiquitin-like protein transferase activity relationship: part_of GO:0016925 ! protein sumoylation [Term] id: GO:0019790 name: obsolete ubiquitin-like hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "ubiquitin-like hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019791 name: obsolete FAT10 hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "FAT10 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019792 name: obsolete APG12 hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "APG12 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019793 name: obsolete ISG15 carrier activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] comment: This term was made obsolete because it is gene product-specific and has no annotations. synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] synonym: "ISG15 carrier activity" EXACT [] is_obsolete: true [Term] id: GO:0019794 name: obsolete nonprotein amino acid metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid metabolic process" EXACT [] synonym: "nonprotein amino acid metabolism" EXACT [] is_obsolete: true replaced_by: GO:0006520 [Term] id: GO:0019795 name: obsolete nonprotein amino acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid anabolism" EXACT [] synonym: "nonprotein amino acid biosynthesis" EXACT [] synonym: "nonprotein amino acid biosynthetic process" EXACT [] synonym: "nonprotein amino acid formation" EXACT [] synonym: "nonprotein amino acid synthesis" EXACT [] xref: MIPS_funcat:01.20.17.01 is_obsolete: true replaced_by: GO:0008652 [Term] id: GO:0019796 name: obsolete nonprotein amino acid catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid breakdown" EXACT [] synonym: "nonprotein amino acid catabolic process" EXACT [] synonym: "nonprotein amino acid catabolism" EXACT [] synonym: "nonprotein amino acid degradation" EXACT [] is_obsolete: true replaced_by: GO:0009063 [Term] id: GO:0019797 name: procollagen-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7] synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "prolyl 3-hydroxylase activity" BROAD [EC:1.14.11.7] synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7] synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7] xref: EC:1.14.11.7 xref: KEGG_REACTION:R03218 xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN xref: Reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen" is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity [Term] id: GO:0019798 name: procollagen-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah] xref: EC:1.14.11 is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0019799 name: tubulin N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "TAT activity" EXACT [EC:2.3.1.108] synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] xref: EC:2.3.1.108 xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity [Term] id: GO:0019800 name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan namespace: biological_process def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219] synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT [] xref: RESID:AA0219 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0019801 name: cyclization of asparagine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302] comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0302 is_a: GO:0006528 ! asparagine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019802 name: cyclization of glutamine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303] comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0303 is_a: GO:0006541 ! glutamine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019803 name: peptidyl-aspartic acid carboxylation namespace: biological_process def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304] xref: RESID:AA0304 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0019804 name: obsolete quinolinate synthetase complex namespace: cellular_component def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers. synonym: "quinolinate synthetase complex" EXACT [] is_obsolete: true consider: GO:0008743 consider: GO:0008987 [Term] id: GO:0019805 name: quinolinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] synonym: "quinolinate anabolism" EXACT [] synonym: "quinolinate biosynthesis" EXACT [] synonym: "quinolinate formation" EXACT [] synonym: "quinolinate synthesis" EXACT [] is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046874 ! quinolinate metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0019806 name: bromide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10] synonym: "bromoperoxidase activity" EXACT [] xref: EC:1.11.1 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0019807 name: aspartoacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15] synonym: "acylase II" RELATED [EC:3.5.1.15] synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15] synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15] xref: EC:3.5.1.15 xref: MetaCyc:ASPARTOACYLASE-RXN xref: Reactome:R-HSA-5691507 "ASPA deacetylates NAA to acetate and L-aspartate" xref: RHEA:10872 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019808 name: polyamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0019809 name: spermidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] is_a: GO:0019808 ! polyamine binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0019810 name: putrescine binding namespace: molecular_function def: "Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] is_a: GO:0019808 ! polyamine binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0019811 name: cocaine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0070405 ! ammonium ion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0019812 name: type I site-specific deoxyribonuclease complex namespace: cellular_component def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] synonym: "type I restriction enzyme complex" EXACT [] is_a: GO:1905347 ! endodeoxyribonuclease complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0019813 name: type III site-specific deoxyribonuclease complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] synonym: "type III restriction enzyme complex" EXACT [] is_a: GO:1905347 ! endodeoxyribonuclease complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0019814 name: immunoglobulin complex namespace: cellular_component def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. subset: goslim_pir synonym: "antibody" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019815 name: B cell receptor complex namespace: cellular_component alt_id: GO:0042570 def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" RELATED [GOC:mah] synonym: "B cell receptor accessory molecule complex" RELATED [] synonym: "B lymphocyte receptor complex" EXACT [] synonym: "B-cell receptor complex" EXACT [] synonym: "B-lymphocyte receptor complex" EXACT [] synonym: "BCR complex" EXACT [] synonym: "immunoglobulin complex, membrane bound" EXACT [] is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0019816 name: obsolete B cell receptor accessory molecule complex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecule and not a location or complex. synonym: "B cell receptor accessory molecule complex" EXACT [] is_obsolete: true consider: GO:0019815 [Term] id: GO:0019817 name: vesicle fusion with peroxisome namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0019819 name: P1 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019820 name: P2 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019821 name: P3 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019822 name: P4 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019823 name: P5 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019824 name: P6 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019825 name: oxygen binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] subset: goslim_pir subset: goslim_plant synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0019826 name: oxygen sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah] is_a: GO:0019825 ! oxygen binding is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0019827 name: stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] synonym: "maintenance of pluripotency" RELATED [GOC:vk] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0098727 ! maintenance of cell number [Term] id: GO:0019828 name: aspartic-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] synonym: "aspartic protease inhibitor activity" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0004190 ! aspartic-type endopeptidase activity [Term] id: GO:0019829 name: ATPase-coupled cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] synonym: "ATP-dependent cation transmembrane transporter activity" EXACT [] synonym: "cation ABC transporter" NARROW [] synonym: "cation-transporting ATPase activity" EXACT [] synonym: "plasma membrane cation-transporting ATPase" NARROW [] xref: Reactome:R-HSA-5251989 "ATP13A4,5 transport divalent ions from extracellular region to cytosol" xref: Reactome:R-HSA-5692480 "ATP13A2 transports cations from cytosol to lysosomal lumen" is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0019830 name: obsolete cadmium sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "cadmium sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046686 [Term] id: GO:0019831 name: obsolete chromate sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "chromate sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046687 [Term] id: GO:0019832 name: obsolete mercuric sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "mercuric sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046689 [Term] id: GO:0019833 name: obsolete ice nucleation activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl] comment: This term was made obsolete because it represents a biological process. synonym: "ice nucleation activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0042309 consider: GO:0050825 [Term] id: GO:0019834 name: phospholipase A2 inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0004859 ! phospholipase inhibitor activity relationship: negatively_regulates GO:0004623 ! phospholipase A2 activity [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0009987 ! cellular process [Term] id: GO:0019836 name: hemolysis by symbiont of host erythrocytes namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354] synonym: "haemolysis in host" EXACT [] synonym: "hemolysin activity" RELATED [] synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232] synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232] synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb] is_a: GO:0001897 ! cytolysis by symbiont of host cells is_a: GO:0052331 ! hemolysis in other organism involved in symbiotic interaction [Term] id: GO:0019837 name: obsolete herbicide susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "herbicide susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0009635 [Term] id: GO:0019838 name: growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] subset: goslim_chembl synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019840 name: isoprenoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] subset: goslim_pir is_a: GO:0008289 ! lipid binding [Term] id: GO:0019841 name: retinol binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [GOC:curators] synonym: "vitamin A1 alcohol binding" EXACT [] synonym: "vitamin A1 binding" EXACT [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0019842 name: vitamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0036094 ! small molecule binding [Term] id: GO:0019843 name: rRNA binding namespace: molecular_function alt_id: GO:0000944 def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "base pairing with rRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0019844 name: obsolete endotoxin activity namespace: molecular_function def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "endotoxin activity" EXACT [] is_obsolete: true consider: GO:0005622 consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019845 name: obsolete exotoxin activity namespace: molecular_function def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "exotoxin activity" EXACT [] is_obsolete: true consider: GO:0005576 consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019846 name: obsolete enterotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "enterotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019847 name: obsolete neurotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. synonym: "neurotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019848 name: obsolete conotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "conotoxin activity" EXACT [] is_obsolete: true consider: GO:0019855 consider: GO:0046929 [Term] id: GO:0019849 name: obsolete cytotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. synonym: "cytotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019852 name: L-ascorbic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:jl, ISBN:0198506732] synonym: "ascorbate metabolic process" EXACT [] synonym: "ascorbate metabolism" EXACT [] synonym: "L-ascorbic acid metabolism" EXACT [] synonym: "vitamin C metabolic process" EXACT [] synonym: "vitamin C metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0019853 name: L-ascorbic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684] synonym: "ascorbate biosynthesis" EXACT [] synonym: "ascorbate biosynthetic process" EXACT [] synonym: "L-ascorbic acid anabolism" EXACT [] synonym: "L-ascorbic acid biosynthesis" EXACT [] synonym: "L-ascorbic acid formation" EXACT [] synonym: "L-ascorbic acid synthesis" EXACT [] synonym: "vitamin C biosynthesis" EXACT [] synonym: "vitamin C biosynthetic process" EXACT [] xref: MetaCyc:PWY-882 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019854 name: L-ascorbic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:go_curators] synonym: "ascorbate catabolic process" EXACT [] synonym: "ascorbate catabolism" EXACT [] synonym: "L-ascorbic acid breakdown" EXACT [] synonym: "L-ascorbic acid catabolism" EXACT [] synonym: "L-ascorbic acid degradation" EXACT [] synonym: "vitamin C catabolic process" EXACT [] synonym: "vitamin C catabolism" EXACT [] xref: MetaCyc:PWY0-301 is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019855 name: calcium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah] is_a: GO:0005246 ! calcium channel regulator activity is_a: GO:0008200 ! ion channel inhibitor activity relationship: negatively_regulates GO:0005262 ! calcium channel activity [Term] id: GO:0019856 name: pyrimidine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] synonym: "pyrimidine base anabolism" EXACT [] synonym: "pyrimidine base biosynthesis" EXACT [] synonym: "pyrimidine base biosynthetic process" EXACT [GOC:go_curators] synonym: "pyrimidine base formation" EXACT [] synonym: "pyrimidine base synthesis" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0019857 name: 5-methylcytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai] synonym: "5-methylcytosine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0019858 name: cytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai] synonym: "cytosine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0019859 name: thymine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] synonym: "thymine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0019860 name: uracil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0019861 name: obsolete flagellum namespace: cellular_component alt_id: GO:0008223 def: "OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [UniProtKB-KW:KW-0282] comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum ; GO:0009288'. synonym: "flagellum" EXACT [] xref: MIPS_funcat:70.32 xref: Wikipedia:Flagellum is_obsolete: true consider: GO:0005929 consider: GO:0009288 [Term] id: GO:0019862 name: IgA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019863 name: IgE binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019864 name: IgG binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149] subset: goslim_chembl is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019865 name: immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin." [GOC:ma] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019866 name: organelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] comment: See also the cellular component term 'outer membrane ; GO:0019867'. is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019869 name: chloride channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a chloride channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017081 ! chloride channel regulator activity relationship: negatively_regulates GO:0005254 ! chloride channel activity [Term] id: GO:0019870 name: potassium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a potassium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0015459 ! potassium channel regulator activity relationship: negatively_regulates GO:0005267 ! potassium channel activity [Term] id: GO:0019871 name: sodium channel inhibitor activity namespace: molecular_function alt_id: GO:0019868 def: "Stops, prevents, or reduces the activity of a sodium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017080 ! sodium channel regulator activity relationship: negatively_regulates GO:0005272 ! sodium channel activity [Term] id: GO:0019872 name: streptomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators] synonym: "streptomycin anabolism" EXACT [] synonym: "streptomycin biosynthesis" EXACT [] synonym: "streptomycin formation" EXACT [] synonym: "streptomycin synthesis" EXACT [] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046343 ! streptomycin metabolic process [Term] id: GO:0019873 name: obsolete tellurium sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "tellurium sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046690 [Term] id: GO:0019874 name: 6-aminohexanoate-cyclic-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16225] synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12] xref: EC:3.5.2.12 xref: KEGG_REACTION:R03448 xref: MetaCyc:3.5.2.12-RXN xref: RHEA:16225 xref: UM-BBD_reactionID:r1097 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0019875 name: 6-aminohexanoate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46] synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46] xref: EC:3.5.1.46 xref: MetaCyc:RXN-3962 xref: RHEA:21364 xref: UM-BBD_enzymeID:e0673 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019876 name: nylon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549] synonym: "nylon breakdown" EXACT [] synonym: "nylon catabolism" EXACT [] synonym: "nylon degradation" EXACT [] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042198 ! nylon metabolic process [Term] id: GO:0019877 name: diaminopimelate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684] synonym: "diaminopimelate anabolism" EXACT [] synonym: "diaminopimelate biosynthesis" EXACT [] synonym: "diaminopimelate formation" EXACT [] synonym: "diaminopimelate synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0019878 name: lysine biosynthetic process via aminoadipic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators] synonym: "lysine anabolism via aminoadipic acid" EXACT [] synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthesis, aminoadipic pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT [] synonym: "lysine formation via aminoadipic acid" EXACT [] synonym: "lysine synthesis via aminoadipic acid" EXACT [] xref: MIPS_funcat:01.01.06.06.01.03 is_a: GO:0009085 ! lysine biosynthetic process [Term] id: GO:0019879 name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg] comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT [] is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019880 name: obsolete bacteriocin susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "bacteriocin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046678 [Term] id: GO:0019881 name: obsolete streptomycin susceptibility/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "streptomycin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046679 [Term] id: GO:0019882 name: antigen processing and presentation namespace: biological_process alt_id: GO:0030333 def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:15771591, PMID:15928678] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antigen presentation" EXACT [] synonym: "antigen processing" EXACT [] xref: MIPS_funcat:36.25.16.03.05 xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019883 name: antigen processing and presentation of endogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, endogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, exogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019885 name: antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process alt_id: GO:0048004 def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, endogenous peptide antigen" BROAD [] synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [] synonym: "antigen processing, endogenous antigen via MHC class I" BROAD [] synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0019886 name: antigen processing and presentation of exogenous peptide antigen via MHC class II namespace: biological_process alt_id: GO:0042591 alt_id: GO:0048005 def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD [] synonym: "antigen presentation, exogenous peptide antigen" BROAD [] synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0019887 name: protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019207 ! kinase regulator activity relationship: has_part GO:0019901 ! protein kinase binding relationship: part_of GO:0045859 ! regulation of protein kinase activity relationship: regulates GO:0004672 ! protein kinase activity [Term] id: GO:0019888 name: protein phosphatase regulator activity namespace: molecular_function alt_id: GO:0008599 alt_id: GO:0008601 alt_id: GO:0030359 alt_id: GO:0030362 def: "Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:ai] synonym: "calcineurin regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "calcineurin, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 2 regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 2, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 3 regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 3, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase type 1 regulator activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 2A regulator activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 2B regulator activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 4 regulator activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] xref: Reactome:R-HSA-180038 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function" is_a: GO:0019208 ! phosphatase regulator activity relationship: has_part GO:0019903 ! protein phosphatase binding relationship: part_of GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0019889 name: pteridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732] synonym: "pteridine metabolism" EXACT [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0019893 name: obsolete DNA replication inhibitor namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication inhibitor" EXACT [] is_obsolete: true replaced_by: GO:0008156 [Term] id: GO:0019894 name: kinesin binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0019895 name: kinesin-associated mitochondrial adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622] is_a: GO:0019894 ! kinesin binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0019896 name: axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] subset: goslim_synapse synonym: "axon transport of mitochondria" EXACT [] is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098930 ! axonal transport relationship: occurs_in GO:1904115 ! axon cytoplasm [Term] id: GO:0019897 name: extrinsic component of plasma membrane namespace: cellular_component alt_id: GO:0000157 def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] synonym: "extrinsic to plasma membrane" EXACT [] synonym: "juxtamembrane" BROAD [] synonym: "peripheral plasma membrane protein" EXACT [] is_a: GO:0019898 ! extrinsic component of membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0019898 name: extrinsic component of membrane namespace: cellular_component alt_id: GO:0030396 def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. subset: goslim_metagenomics synonym: "extrinsic to membrane" EXACT [] synonym: "peripheral membrane protein" EXACT [] xref: MIPS_funcat:42.27.03 xref: Wikipedia:Peripheral_membrane_protein is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016020 ! membrane [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0019900 name: kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019901 name: protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] is_a: GO:0019900 ! kinase binding [Term] id: GO:0019902 name: phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any phosphatase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019903 name: protein phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein phosphatase." [GOC:jl] is_a: GO:0019902 ! phosphatase binding [Term] id: GO:0019904 name: protein domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] subset: goslim_chembl synonym: "protein domain-specific binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019905 name: syntaxin binding namespace: molecular_function alt_id: GO:0030347 alt_id: GO:0030349 alt_id: GO:0050430 alt_id: GO:0051535 def: "Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732] synonym: "syntaxin-13 binding" NARROW [] synonym: "syntaxin-2 binding" NARROW [] synonym: "syntaxin-5 binding" NARROW [] synonym: "syntaxin-6 binding" NARROW [] is_a: GO:0000149 ! SNARE binding [Term] id: GO:0019907 name: cyclin-dependent protein kinase activating kinase holoenzyme complex namespace: cellular_component def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210] synonym: "CAK complex" EXACT [] synonym: "CDK-activating kinase complex" EXACT [] xref: IntAct:EBI-1246076 xref: IntAct:EBI-9868598 is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex is_a: GO:0150005 ! enzyme activator complex [Term] id: GO:0019908 name: nuclear cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0019909 name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity namespace: molecular_function def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity relationship: regulates GO:0004741 ! [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Term] id: GO:0019910 name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502] comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0019911 name: structural constituent of myelin sheath namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0043209 ! myelin sheath relationship: occurs_in GO:0043209 ! myelin sheath [Term] id: GO:0019912 name: cyclin-dependent protein kinase activating kinase activity namespace: molecular_function alt_id: GO:0019913 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] synonym: "CAK" EXACT [] synonym: "cdk-activating kinase activity" EXACT [] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] is_a: GO:0004672 ! protein kinase activity is_a: GO:0030295 ! protein kinase activator activity relationship: part_of GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity [Term] id: GO:0019914 name: cyclin-dependent protein kinase activating kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1 is_a: GO:0019887 ! protein kinase regulator activity relationship: regulates GO:0019912 ! cyclin-dependent protein kinase activating kinase activity [Term] id: GO:0019915 name: lipid storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] synonym: "lipid retention" EXACT [GOC:dph, GOC:tb] synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb] synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb] synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb] synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb] synonym: "storage of lipids" EXACT [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0019916 name: peptidyl-D-alanine racemization, direct namespace: biological_process def: "The racemization of peptidyl-alanine." [RESID:AA0191] xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019917 name: peptidyl-D-alanine racemization via peptidyl-L-serine namespace: biological_process def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191] xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019918 name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] xref: RESID:AA0067 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019919 name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT [] xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019920 name: peptidyl-1-thioglycine biosynthetic process, internal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT [] synonym: "peptidyl-1-thioglycine formation, internal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019921 name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019922 name: protein-chromophore linkage via peptidyl-cysteine namespace: biological_process def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma] is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019923 name: alpha-1-microglobulin-chromophore linkage namespace: biological_process def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224] xref: RESID:AA0224 is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine [Term] id: GO:0019926 name: peptidyl-tryptophan oxidation to tryptophyl quinone namespace: biological_process def: "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148] comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. is_a: GO:0018158 ! protein oxidation is_a: GO:0018211 ! peptidyl-tryptophan modification relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone [Term] id: GO:0019927 name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313] xref: RESID:AA0313 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019928 name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid namespace: biological_process def: "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314] xref: RESID:AA0314 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019929 name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid namespace: biological_process def: "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315] xref: RESID:AA0315 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0019930 name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0316 is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019931 name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312] xref: RESID:AA0312 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019932 name: second-messenger-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell." [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system] synonym: "second messenger mediated signaling" EXACT [] synonym: "second messenger mediated signalling" EXACT [] synonym: "second messenger-mediated signaling" EXACT [] synonym: "second messenger-mediated signalling" EXACT [] synonym: "second-messenger-mediated signal transduction" EXACT [GOC:signaling] synonym: "second-messenger-mediated signalling" EXACT [] xref: MIPS_funcat:30.01.09 is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0019933 name: cAMP-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "3',5' cAMP-mediated signaling" EXACT [] synonym: "3',5' cAMP-mediated signalling" EXACT [] synonym: "3',5'-cAMP-mediated signaling" EXACT [] synonym: "3',5'-cAMP-mediated signalling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT [] synonym: "cAMP signaling" EXACT [] synonym: "cAMP signalling" EXACT [] synonym: "cAMP-mediated signal transduction" EXACT [] synonym: "cAMP-mediated signalling" EXACT [] synonym: "cyclic AMP-mediated signaling" EXACT [] synonym: "cyclic AMP-mediated signalling" EXACT [] xref: MIPS_funcat:30.01.09.07 is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019934 name: cGMP-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "cGMP-mediated signalling" EXACT [] is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019935 name: cyclic-nucleotide-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "cyclic-nucleotide-mediated signalling" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019936 name: obsolete inositol phospholipid-mediated signaling namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ceb] comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling. synonym: "inositol phospholipid-mediated signaling" EXACT [] synonym: "inositol phospholipid-mediated signalling" EXACT [] is_obsolete: true consider: GO:0048016 consider: GO:0048017 [Term] id: GO:0019937 name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic namespace: biological_process def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018419 ! protein catenane formation is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019938 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic namespace: biological_process alt_id: GO:0042266 def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019939 name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308] synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0308 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0045234 ! protein palmitoleylation [Term] id: GO:0019940 name: obsolete SUMO-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein. synonym: "SUMO-dependent protein breakdown" EXACT [] synonym: "SUMO-dependent protein catabolic process" EXACT [] synonym: "SUMO-dependent protein catabolism" EXACT [] synonym: "SUMO-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0016925 consider: GO:0016926 [Term] id: GO:0019941 name: modification-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] synonym: "modification-dependent protein breakdown" EXACT [] synonym: "modification-dependent protein catabolism" EXACT [] synonym: "modification-dependent protein degradation" EXACT [] synonym: "modification-dependent proteolysis" EXACT [GOC:rl] synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl] synonym: "modification-initiated protein catabolism" EXACT [GOC:rl] synonym: "modification-initiated proteolysis" EXACT [GOC:rl] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein-ligand-dependent protein catabolic process" NARROW [] synonym: "protein-ligand-dependent protein catabolism" NARROW [] is_a: GO:0043632 ! modification-dependent macromolecule catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0019942 name: obsolete NEDD8 class-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl] comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. synonym: "NEDD8 class-dependent protein breakdown" EXACT [] synonym: "NEDD8 class-dependent protein catabolic process" EXACT [] synonym: "NEDD8 class-dependent protein catabolism" EXACT [] synonym: "NEDD8 class-dependent protein degradation" EXACT [] synonym: "RUB1-dependent protein catabolic process" EXACT [] synonym: "RUB1-dependent protein catabolism" EXACT [] synonym: "RUB1-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0045116 [Term] id: GO:0019948 name: SUMO activating enzyme activity namespace: molecular_function alt_id: GO:0017115 def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] synonym: "SMT3 activating enzyme" EXACT [] synonym: "SUMO E1 activator enzyme" EXACT [] xref: Reactome:R-HSA-2990833 "Conjugation of SUMO1 to UBA2:SAE1" xref: Reactome:R-HSA-2993781 "Conjugation of SUMO3 to UBA2:SAE1" xref: Reactome:R-HSA-2993784 "Conjugation of SUMO2 to UBA2:SAE1" is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019950 name: SMT3-dependent protein catabolic process namespace: biological_process alt_id: GO:0019946 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231] synonym: "SMT3-dependent protein breakdown" EXACT [] synonym: "SMT3-dependent protein catabolism" EXACT [] synonym: "SMT3-dependent protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0019951 name: Smt3-protein conjugation namespace: biological_process alt_id: GO:0019947 def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl] synonym: "Smt3p-protein conjugation" EXACT [] xref: MIPS_funcat:14.07.07 is_a: GO:0032446 ! protein modification by small protein conjugation relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546] comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] synonym: "parthenogenesis" RELATED [https://en.wikipedia.org/wiki/Parthenogenesis] xref: Wikipedia:Asexual_reproduction is_a: GO:0000003 ! reproduction [Term] id: GO:0019955 name: cytokine binding namespace: molecular_function alt_id: GO:0019965 def: "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "IL binding" NARROW [] synonym: "interleukin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019956 name: chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:ai, GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, PMID:12183377] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019957 name: C-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019958 name: C-X-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019959 name: interleukin-8 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-8." [GOC:jl] synonym: "IL-8 binding" EXACT [] is_a: GO:0019958 ! C-X-C chemokine binding [Term] id: GO:0019960 name: C-X3-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019961 name: interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [PMID:9607096, Wikipedia:Interferon] synonym: "IFN binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019962 name: type I interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha binding" NARROW [] synonym: "interferon-alpha/beta binding" NARROW [] synonym: "interferon-beta binding" NARROW [] synonym: "interferon-delta binding" NARROW [] synonym: "interferon-epsilon binding" NARROW [] synonym: "interferon-kappa binding" NARROW [] synonym: "interferon-omega binding" NARROW [] synonym: "interferon-tau binding" NARROW [] synonym: "interferon-zeta binding" NARROW [] synonym: "type I IFN binding" EXACT [GOC:mah] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019964 name: interferon-gamma binding namespace: molecular_function def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383, PR:000000017] synonym: "IFN-gamma binding" EXACT [GOC:mah, PR:000000017] synonym: "IFNG binding" EXACT [GOC:mah] synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019966 name: interleukin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-1." [GOC:jl, ISBN:0198506732] synonym: "IL-1 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019969 name: interleukin-10 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-10." [GOC:jl] synonym: "IL-10 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019970 name: interleukin-11 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-11." [GOC:jl] synonym: "IL-11 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019972 name: interleukin-12 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-12." [GOC:jl] synonym: "IL-12 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019973 name: interleukin-13 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-13." [GOC:jl] synonym: "IL-13 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019974 name: interleukin-14 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-14." [GOC:jl] synonym: "IL-14 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019975 name: interleukin-17 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines." [GOC:add, GOC:jl] synonym: "IL-17 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019976 name: interleukin-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-2." [GOC:jl] synonym: "IL-2 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019977 name: interleukin-21 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-21." [GOC:jl] synonym: "IL-21 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019978 name: interleukin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-3." [GOC:jl] synonym: "IL-3 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019979 name: interleukin-4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-4." [GOC:jl] synonym: "IL-4 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019980 name: interleukin-5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-5." [GOC:jl] synonym: "IL-5 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019981 name: interleukin-6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-6." [GOC:jl] synonym: "IL-6 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019982 name: interleukin-7 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-7." [GOC:jl] synonym: "IL-7 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019983 name: interleukin-9 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-9." [GOC:jl] synonym: "IL-9 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019985 name: translesion synthesis namespace: biological_process def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] synonym: "bypass DNA synthesis" EXACT [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0006301 ! postreplication repair [Term] id: GO:0019987 name: obsolete negative regulation of anti-apoptosis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] comment: This term was made obsolete because it was ill-defined. synonym: "down regulation of anti-apoptosis" EXACT [] synonym: "down-regulation of anti-apoptosis" EXACT [] synonym: "downregulation of anti-apoptosis" EXACT [] synonym: "inhibition of anti-apoptosis" NARROW [] synonym: "negative regulation of anti-apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0019988 name: charged-tRNA amino acid modification namespace: biological_process alt_id: GO:0030630 def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg] synonym: "charged tRNA amino acid modification" EXACT [] synonym: "charged tRNA modification" EXACT [] synonym: "charged-tRNA modification" RELATED [] synonym: "pre-translational amino acid modification" EXACT [] synonym: "pre-translational protein modification" EXACT [] synonym: "pretranslation protein modification" EXACT [] synonym: "pretranslational amino acid modification" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0019990 name: pteridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] synonym: "pteridine breakdown" EXACT [] synonym: "pteridine catabolism" EXACT [] synonym: "pteridine degradation" EXACT [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process [Term] id: GO:0019991 name: septate junction assembly namespace: biological_process def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] is_a: GO:0120192 ! tight junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0019992 name: diacylglycerol binding namespace: molecular_function def: "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] is_a: GO:0008289 ! lipid binding [Term] id: GO:0020002 name: host cell plasma membrane namespace: cellular_component def: "The plasma membrane surrounding a host cell." [GOC:mb] is_a: GO:0033644 ! host cell membrane [Term] id: GO:0020003 name: symbiont-containing vacuole namespace: cellular_component def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb] comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. synonym: "bacterium-containing vacuole" NARROW [PMID:22042847] synonym: "parasitophorous vacuole" EXACT [] synonym: "pathogen-occupied vacuole" NARROW [PMID:24034612] synonym: "Salmonella-containing vacuole" NARROW [PMID:10449405, PMID:15121880] synonym: "SCV" EXACT [PMID:10449405, PMID:15121880] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0065010 ! extracellular membrane-bounded organelle [Term] id: GO:0020004 name: symbiont-containing vacuolar space namespace: cellular_component def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar space" EXACT [] synonym: "symbiont-containing vacuole space" RELATED [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020005 name: symbiont-containing vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar membrane" EXACT [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020006 name: symbiont-containing vacuolar membrane network namespace: cellular_component def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173] synonym: "parasitophorous vacuolar membrane network" EXACT [] synonym: "symbiont-containing vacuole membrane network" EXACT [] synonym: "tubulovesicular network" NARROW [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane [Term] id: GO:0020007 name: apical complex namespace: cellular_component def: "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation." [GOC:giardia, GOC:mb, PMID:16518471] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0020008 name: rhoptry namespace: cellular_component def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398] synonym: "paired organelles" RELATED [] synonym: "toxoneme" RELATED [] xref: Wikipedia:Rhoptry is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020009 name: microneme namespace: cellular_component def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218] synonym: "sarconeme" RELATED [] xref: Wikipedia:Microneme is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020010 name: conoid namespace: cellular_component def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020011 name: apicoplast namespace: cellular_component def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] xref: Wikipedia:Apicoplast is_a: GO:0009536 ! plastid [Term] id: GO:0020012 name: mitigation of host immune response namespace: biological_process alt_id: GO:0051805 def: "A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "evasion or tolerance of host immune response" RELATED [] synonym: "evasion or tolerance of immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "immune evasion" EXACT [] is_a: GO:0030682 ! mitigation of host defenses by symbiont is_a: GO:0052572 ! response to host immune response [Term] id: GO:0020013 name: modulation by symbiont of host erythrocyte aggregation namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024] comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting. synonym: "rosetting" EXACT [] xref: Wikipedia:Rosetting is_a: GO:0034118 ! regulation of erythrocyte aggregation is_a: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0020014 name: schizogony namespace: biological_process def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb] xref: Wikipedia:Protozoal_merogony is_a: GO:0051301 ! cell division [Term] id: GO:0020015 name: glycosome namespace: cellular_component def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] subset: goslim_pir xref: Wikipedia:Glycosome is_a: GO:0005777 ! peroxisome [Term] id: GO:0020016 name: ciliary pocket namespace: cellular_component def: "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes." [GOC:cilia, GOC:mb] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. synonym: "cilial pocket" EXACT [] synonym: "cilium pocket" EXACT [] synonym: "flagellar pocket" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium [Term] id: GO:0020018 name: ciliary pocket membrane namespace: cellular_component def: "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket)." [GOC:cilia, GOC:mb] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. synonym: "cilial pocket membrane" EXACT [] synonym: "cilium pocket membrane" EXACT [] synonym: "flagellar pocket membrane" EXACT [] is_a: GO:0060170 ! ciliary membrane relationship: part_of GO:0020016 ! ciliary pocket [Term] id: GO:0020020 name: food vacuole namespace: cellular_component alt_id: GO:0005772 def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb] synonym: "digestive vacuole" EXACT [] is_a: GO:0032010 ! phagolysosome [Term] id: GO:0020021 name: immortalization of host cell namespace: biological_process def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell immortalization" EXACT [] synonym: "host cell transformation" EXACT [] synonym: "transformation of host cell" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0020022 name: acidocalcisome namespace: cellular_component def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] subset: goslim_pir synonym: "metachromatic granule" EXACT [PMID:15738951] synonym: "polyphosphate vacuole" RELATED [PMID:15738951] synonym: "volutin granule" EXACT [PMID:15738951] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0020023 name: kinetoplast namespace: cellular_component def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] xref: Wikipedia:Kinetoplast is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0020025 name: subpellicular microtubule namespace: cellular_component def: "Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid." [GOC:mb, PMID:24800253] is_a: GO:0005874 ! microtubule relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020026 name: merozoite dense granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] synonym: "dense body" RELATED [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0020027 name: hemoglobin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl] synonym: "haemoglobin metabolic process" EXACT [] synonym: "haemoglobin metabolism" EXACT [] synonym: "hemoglobin metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0020028 name: endocytic hemoglobin import namespace: biological_process def: "The directed movement into a tissue or a cell or organelle of externally available hemoglobin by receptor-mediated endocytosis." [GOC:mb] synonym: "haemoglobin uptake" EXACT [] synonym: "hemoglobin uptake" EXACT [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0015886 ! heme transport is_a: GO:0017038 ! protein import is_a: GO:0033212 ! iron import into cell is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0020030 name: infected host cell surface knob namespace: cellular_component def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020031 name: polar ring of apical complex namespace: cellular_component def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] synonym: "anterior polar ring of apical complex" EXACT [] synonym: "upper polar ring of apical complex" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020032 name: basal ring of apical complex namespace: cellular_component def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] synonym: "lower polar ring of apical complex" EXACT [] synonym: "posterior polar ring of apical complex" EXACT [] synonym: "preconoidal ring of apical complex" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020033 name: antigenic variation namespace: biological_process alt_id: GO:0020034 def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb] synonym: "surface antigen variation" NARROW [] xref: Wikipedia:Antigenic_variation is_a: GO:0020012 ! mitigation of host immune response [Term] id: GO:0020035 name: cytoadherence to microvasculature, mediated by symbiont protein namespace: biological_process def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb] synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW [] synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD [] synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT [] synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD [] is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0020036 name: Maurer's cleft namespace: cellular_component def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] synonym: "Maurers cleft" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020037 name: heme binding namespace: molecular_function def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] synonym: "haem binding" EXACT [] xref: MIPS_funcat:16.21.01 is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0020038 name: subpellicular network namespace: cellular_component def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0020039 ! pellicle [Term] id: GO:0020039 name: pellicle namespace: cellular_component def: "The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021502 name: neural fold elevation formation namespace: biological_process def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021503 name: neural fold bending namespace: biological_process def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021504 name: neural fold hinge point formation namespace: biological_process def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. synonym: "neural fold furrowing" NARROW [GOC:cls] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021505 name: neural fold folding namespace: biological_process def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021506 name: anterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021507 name: posterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021508 name: floor plate formation namespace: biological_process def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007418 ! ventral midline development relationship: part_of GO:0033505 ! floor plate morphogenesis [Term] id: GO:0021509 name: roof plate formation namespace: biological_process def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021511 name: spinal cord patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021512 name: spinal cord anterior/posterior patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord anterior-posterior patterning" EXACT [] synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021513 name: spinal cord dorsal/ventral patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal-ventral patterning" EXACT [] synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021516 name: dorsal spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11179871] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021518 name: spinal cord commissural neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord [Term] id: GO:0021519 name: spinal cord association neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021527 ! spinal cord association neuron differentiation [Term] id: GO:0021520 name: spinal cord motor neuron cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021521 name: ventral spinal cord interneuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021524 name: visceral motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021525 name: lateral motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021526 name: medial motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021527 name: spinal cord association neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021516 ! dorsal spinal cord development [Term] id: GO:0021528 name: commissural neuron differentiation in spinal cord namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021529 name: spinal cord oligodendrocyte cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021530 name: spinal cord oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021778 ! oligodendrocyte cell fate specification relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation [Term] id: GO:0021531 name: spinal cord radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16185248] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in spinal cord" EXACT [] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0060019 ! radial glial cell differentiation [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021536 name: diencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021537 name: telencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021538 name: epithalamus development namespace: biological_process def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021539 name: subthalamus development namespace: biological_process def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "ventral thalamus development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021540 name: corpus callosum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0022038 ! corpus callosum development [Term] id: GO:0021541 name: ammon gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "Ammon's horn development" RELATED [GOC:cls] synonym: "cornu ammonis development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021542 name: dentate gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021543 name: pallium development namespace: biological_process def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021544 name: subpallium development namespace: biological_process def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021675 ! nerve development [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021549 name: cerebellum development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021552 name: midbrain-hindbrain boundary structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus structural organization" RELATED [GOC:cls] synonym: "MHB structural organization" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis [Term] id: GO:0021553 name: olfactory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN 1 development" RELATED [GOC:cls] synonym: "cranial nerve 1 development" EXACT [GOC:cls] synonym: "cranial nerve I development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021554 name: optic nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II development" RELATED [GOC:cls] synonym: "cranial nerve 2 development" EXACT [GOC:cls] synonym: "cranial nerve II development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021557 name: oculomotor nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III development" RELATED [GOC:cls] synonym: "cranial nerve 3 development" EXACT [GOC:cls] synonym: "cranial nerve III development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021558 name: trochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV development" RELATED [GOC:cls] synonym: "cranial nerve 4 development" EXACT [GOC:cls] synonym: "cranial nerve IV development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021560 name: abducens nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [GOC:cls] synonym: "cranial nerve 6 development" EXACT [GOC:cls] synonym: "cranial nerve VI development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021561 name: facial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII development" RELATED [GOC:cls] synonym: "cranial nerve 7 development" EXACT [GOC:cls] synonym: "cranial nerve VII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021562 name: vestibulocochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "acoustic nerve development" EXACT [PMID:11533729] synonym: "CN VIII development" EXACT [GOC:cls] synonym: "cranial nerve 8 development" EXACT [GOC:cls] synonym: "cranial nerve VIII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021563 name: glossopharyngeal nerve development namespace: biological_process def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX development" RELATED [GOC:cls] synonym: "cranial nerve 9 development" EXACT [GOC:cls] synonym: "cranial nerve IX development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021564 name: vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X development" RELATED [GOC:cls] synonym: "cranial nerve 10 development" RELATED [GOC:cls] synonym: "cranial nerve X development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021565 name: accessory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI development" RELATED [GOC:cls] synonym: "cranial nerve 11 development" RELATED [GOC:cls] synonym: "cranial nerve XI development" EXACT [GOC:cls] synonym: "spinal accessory nerve development" EXACT [PMID:11533729] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021566 name: hypoglossal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII development" RELATED [GOC:cls] synonym: "cranial nerve 12 development" RELATED [GOC:cls] synonym: "cranial nerve XII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021567 name: rhombomere 1 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021568 name: rhombomere 2 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021569 name: rhombomere 3 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021570 name: rhombomere 4 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021571 name: rhombomere 5 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021572 name: rhombomere 6 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021573 name: rhombomere 7 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021574 name: rhombomere 8 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "rhombencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021577 name: hindbrain structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "hindbrain structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021626 ! central nervous system maturation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021581 name: medulla oblongata structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla oblongata structural organisation" EXACT [GOC:mah] synonym: "medulla structural maturation" RELATED [] synonym: "myelencephalon structural maturation" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021585 name: pons structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "pons structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021587 name: cerebellum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021588 name: cerebellum formation namespace: biological_process def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021589 name: cerebellum structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellum structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021590 name: cerebellum maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021591 name: ventricular system development namespace: biological_process def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021592 name: fourth ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021595 name: rhombomere structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "rhombomere structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021597 name: central nervous system structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. synonym: "central nervous system structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021598 name: abducens nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021599 name: abducens nerve formation namespace: biological_process def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI biosynthesis" RELATED [] synonym: "CN VI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021600 name: abducens nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "abducens nerve structural organisation" EXACT [GOC:mah] synonym: "CN VI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021601 name: abducens nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021604 name: cranial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cranial nerve structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021682 ! nerve maturation relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021606 name: accessory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI maturation" RELATED [] synonym: "spinal accessory nerve maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021607 name: accessory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021608 name: accessory nerve formation namespace: biological_process def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI biosynthesis" RELATED [] synonym: "CN XI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021609 name: accessory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "accessory nerve structural organisation" EXACT [GOC:mah] synonym: "CN XI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021610 name: facial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021611 name: facial nerve formation namespace: biological_process def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII biosynthesis" RELATED [] synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021612 name: facial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] synonym: "facial nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021613 name: facial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021614 name: glossopharyngeal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021616 name: glossopharyngeal nerve formation namespace: biological_process def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX biosynthesis" RELATED [] synonym: "CN IX formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021617 name: glossopharyngeal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX structural organization" RELATED [] synonym: "glossopharyngeal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021618 name: hypoglossal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021619 name: hypoglossal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021620 name: hypoglossal nerve formation namespace: biological_process def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII biosynthesis" RELATED [] synonym: "CN XII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021621 name: hypoglossal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII structural organization" RELATED [] synonym: "hypoglossal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021622 name: oculomotor nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021623 name: oculomotor nerve formation namespace: biological_process def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III biosynthesis" RELATED [] synonym: "CN III formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021624 name: oculomotor nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III structural organization" RELATED [] synonym: "oculomotor nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021625 name: oculomotor nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021627 name: olfactory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021628 name: olfactory nerve formation namespace: biological_process def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I biosynthesis" RELATED [] synonym: "CN I formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021629 name: olfactory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I structural organization" RELATED [] synonym: "olfactory nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021630 name: olfactory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "CN I maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021631 name: optic nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021632 name: optic nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021633 name: optic nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II structural organization" RELATED [] synonym: "optic nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021634 name: optic nerve formation namespace: biological_process def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II biosynthesis" RELATED [] synonym: "CN II formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021637 name: trigeminal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V structural organization" RELATED [] synonym: "trigeminal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021639 name: trochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CH IV morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021640 name: trochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021641 name: trochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV structural organization" RELATED [] synonym: "trochlear nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021642 name: trochlear nerve formation namespace: biological_process def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV biosynthesis" RELATED [] synonym: "CN IV formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021643 name: vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021644 name: vagus nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021645 name: vagus nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X structural organization" RELATED [] synonym: "vagus nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021646 name: vagus nerve formation namespace: biological_process def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X biosynthesis" RELATED [] synonym: "CN X formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021647 name: vestibulocochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "auditory nerve maturation" RELATED [] synonym: "CN VIII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021648 name: vestibulocochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VIII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021649 name: vestibulocochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] synonym: "vestibulocochlear nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021650 name: vestibulocochlear nerve formation namespace: biological_process def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021651 name: rhombomere 1 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021567 ! rhombomere 1 development [Term] id: GO:0021652 name: rhombomere 1 formation namespace: biological_process def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021653 name: rhombomere 1 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 1 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021594 ! rhombomere formation [Term] id: GO:0021655 name: rhombomere 2 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021568 ! rhombomere 2 development [Term] id: GO:0021656 name: rhombomere 2 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 2 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021657 name: rhombomere 2 formation namespace: biological_process def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021658 name: rhombomere 3 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021569 ! rhombomere 3 development [Term] id: GO:0021659 name: rhombomere 3 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 3 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021660 name: rhombomere 3 formation namespace: biological_process def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021661 name: rhombomere 4 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021570 ! rhombomere 4 development [Term] id: GO:0021662 name: rhombomere 4 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 4 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021663 name: rhombomere 4 formation namespace: biological_process def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021664 name: rhombomere 5 morphogenesis namespace: biological_process def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021571 ! rhombomere 5 development [Term] id: GO:0021665 name: rhombomere 5 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 5 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021666 name: rhombomere 5 formation namespace: biological_process def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021667 name: rhombomere 6 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021572 ! rhombomere 6 development [Term] id: GO:0021668 name: rhombomere 6 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 6 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021669 name: rhombomere 6 formation namespace: biological_process def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021670 name: lateral ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021671 name: rhombomere 7 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021573 ! rhombomere 7 development [Term] id: GO:0021672 name: rhombomere 7 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 7 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021673 name: rhombomere 7 formation namespace: biological_process def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021674 name: rhombomere 8 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021574 ! rhombomere 8 development [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021676 name: rhombomere 8 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 8 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021677 name: rhombomere 8 formation namespace: biological_process def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021678 name: third ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021679 name: cerebellar molecular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021680 name: cerebellar Purkinje cell layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021681 name: cerebellar granular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021675 ! nerve development [Term] id: GO:0021683 name: cerebellar granular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021684 name: cerebellar granular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021685 name: cerebellar granular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar granular layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021686 name: cerebellar granular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021687 name: cerebellar molecular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021688 name: cerebellar molecular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021689 name: cerebellar molecular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar molecular layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021690 name: cerebellar molecular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021691 name: cerebellar Purkinje cell layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021692 name: cerebellar Purkinje cell layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021693 name: cerebellar Purkinje cell layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar Purkinje cell layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021694 name: cerebellar Purkinje cell layer formation namespace: biological_process def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021695 name: cerebellar cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021696 name: cerebellar cortex morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021587 ! cerebellum morphogenesis relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021697 name: cerebellar cortex formation namespace: biological_process def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021698 name: cerebellar cortex structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar cortex structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021699 name: cerebellar cortex maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021590 ! cerebellum maturation relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic is_a: GO:0032502 ! developmental process [Term] id: GO:0021701 name: cerebellar Golgi cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021702 name: cerebellar Purkinje cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021704 ! locus ceruleus morphogenesis [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021707 name: cerebellar granule cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021708 name: Lugaro cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021709 name: cerebellar basket cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021710 name: cerebellar stellate cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021711 name: cerebellar unipolar brush cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021712 name: candelabrum cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021713 name: inferior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021714 name: inferior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021579 ! medulla oblongata morphogenesis relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021715 name: inferior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive biosynthesis" RELATED [] synonym: "inferior olive formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021580 ! medulla oblongata formation relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021716 name: inferior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olivary nucleus structural organisation" EXACT [GOC:mah] synonym: "inferior olive structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021581 ! medulla oblongata structural organization relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021717 name: inferior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021582 ! medulla oblongata maturation relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021721 name: superior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olivary nucleus structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021585 ! pons structural organization relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021723 name: medullary reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, http://en.wikipedia.org/wiki/Rhombencephalon, http://www.brainspan.org] comment: This term was added by GO_REF:0000021. synonym: "rhombencephalic reticular formation development" BROAD [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021724 name: inferior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000366] comment: This term was added by GO_REF:0000021. synonym: "inferior central nucleus development" BROAD [] synonym: "posterior raphe nucleus development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021725 name: superior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000440] comment: This term was added by GO_REF:0000021. synonym: "anterior raphe nucleus development" BROAD [] synonym: "superior central nucleus development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021726 name: lateral reticular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021727 name: intermediate reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "intermediate reticular nucleus development" EXACT [http://www.brainspan.org] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021728 name: inferior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021729 name: superior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021730 name: trigeminal sensory nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021731 name: trigeminal motor nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021735 name: dentate nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021736 name: globose nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021737 name: emboliform nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021738 name: fastigial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021739 name: mesencephalic trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021740 name: principal sensory nucleus of trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. synonym: "pontine nucleus development" BROAD [GOC:dph] is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021741 name: spinal trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021742 name: abducens nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021743 name: hypoglossal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021744 name: dorsal motor nucleus of vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021745 name: nucleus ambiguus development namespace: biological_process def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021746 name: solitary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021747 name: cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021748 name: dorsal cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021749 name: ventral cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021750 name: vestibular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16221589] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021752 name: inferior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021751 ! salivary nucleus development [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021751 ! salivary nucleus development [Term] id: GO:0021754 name: facial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021755 name: eurydendroid cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15892096] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021756 name: striatum development namespace: biological_process def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "neostriatum development" EXACT [] synonym: "striate nucleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021757 name: caudate nucleus development namespace: biological_process def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021758 name: putamen development namespace: biological_process def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021759 name: globus pallidus development namespace: biological_process def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "pallidum development" EXACT [PMID:16271465] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021761 name: limbic system development namespace: biological_process def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021762 name: substantia nigra development namespace: biological_process def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0021763 name: subthalamic nucleus development namespace: biological_process def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "corpus luysi development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021539 ! subthalamus development [Term] id: GO:0021764 name: amygdala development namespace: biological_process def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021765 name: cingulate gyrus development namespace: biological_process def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021766 name: hippocampus development namespace: biological_process def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420, UBERON:0002421] comment: This term was added by GO_REF:0000021. synonym: "hippocampal formation development" EXACT [ABA:HPF] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021767 name: mammillary body development namespace: biological_process def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021768 name: nucleus accumbens development namespace: biological_process def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "accumbens nucleus development" EXACT [GOC:dgh] synonym: "ventral striatum development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021769 name: orbitofrontal cortex development namespace: biological_process def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021770 name: parahippocampal gyrus development namespace: biological_process def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "hippocampal gyrus development" EXACT [GOC:dgh] xref: Wikipedia:parahippocampal_gyrus is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021771 name: lateral geniculate nucleus development namespace: biological_process def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "LGN development" EXACT [GOC:dgh] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021794 ! thalamus development [Term] id: GO:0021772 name: olfactory bulb development namespace: biological_process def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021773 name: striatal medium spiny neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741] synonym: "striatal MSN differentiation" EXACT [PMID:25804741] is_a: GO:0021879 ! forebrain neuron differentiation relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021774 name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021775 name: smoothened signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021776 name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0021520 ! spinal cord motor neuron cell fate specification relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021777 name: obsolete BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "OBSOLETE. A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [] is_obsolete: true [Term] id: GO:0021778 name: oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021780 ! glial cell fate specification relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment [Term] id: GO:0021779 name: oligodendrocyte cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021780 name: glial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0021781 name: glial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048468 ! cell development relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021783 name: preganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021784 name: postganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048483 ! autonomic nervous system development relationship: part_of GO:0007422 ! peripheral nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021785 name: branchiomotor neuron axon guidance namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "BMN axon guidance" EXACT [PMID:14699587] synonym: "branchial motor axon guidance" EXACT [PMID:14699587] synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587] is_a: GO:0008045 ! motor neuron axon guidance [Term] id: GO:0021786 name: branchiomotor neuron axon guidance in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021787 name: chemorepulsion of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021788 name: chemoattraction of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021789 name: branchiomotor neuron axon guidance in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021790 name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021791 name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021792 name: chemoattraction of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0061642 ! chemoattraction of axon intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0021785 ! branchiomotor neuron axon guidance relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021793 name: chemorepulsion of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0061643 ! chemorepulsion of axon intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0021785 ! branchiomotor neuron axon guidance relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021794 name: thalamus development namespace: biological_process def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021795 name: cerebral cortex cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021796 name: cerebral cortex regionalization namespace: biological_process def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex arealization" EXACT [] synonym: "cerebral cortex pattern biosynthesis" EXACT [] synonym: "cerebral cortex pattern formation" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0021978 ! telencephalon regionalization relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021797 name: forebrain anterior/posterior pattern specification namespace: biological_process def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain anterior-posterior pattern specification" EXACT [] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021798 name: forebrain dorsal/ventral pattern formation namespace: biological_process def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021799 name: cerebral cortex radially oriented cell migration namespace: biological_process def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021800 name: cerebral cortex tangential migration namespace: biological_process def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021801 name: cerebral cortex radial glia guided migration namespace: biological_process def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glial-guided locomotion" RELATED [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0021802 name: somal translocation namespace: biological_process def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration [Term] id: GO:0021803 name: extension of leading cell process to pial surface namespace: biological_process def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021804 name: negative regulation of cell adhesion in ventricular zone namespace: biological_process def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell adhesion in ventricular zone" EXACT [] synonym: "down-regulation of cell adhesion in ventricular zone" EXACT [] synonym: "downregulation of cell adhesion in ventricular zone" EXACT [] synonym: "inhibition of cell adhesion in ventricular zone" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021805 name: cell movement involved in somal translocation namespace: biological_process def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: part_of GO:0021802 ! somal translocation relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021806 name: initiation of movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021807 name: motogenic signaling initiating cell movement in cerebral cortex namespace: biological_process def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021808 name: cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration namespace: biological_process def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021809 name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021810 name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021811 name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio] synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021812 name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021813 name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration [Term] id: GO:0021814 name: cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: part_of GO:0021801 ! cerebral cortex radial glia guided migration relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021815 name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0021801 ! cerebral cortex radial glia guided migration relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021816 name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration namespace: biological_process def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration is_a: GO:0031269 ! pseudopodium assembly [Term] id: GO:0021817 name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration namespace: biological_process def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [Term] id: GO:0021818 name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030036 ! actin cytoskeleton organization relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021819 name: layer formation in cerebral cortex namespace: biological_process def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex lamination" RELATED [PMID:12626695] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021820 name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration" EXACT [GOC:mah] synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021821 name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination namespace: biological_process def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021822 name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:1903976 ! negative regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021823 name: cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "chain migration" RELATED [PMID:12626695] is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021824 name: cerebral cortex tangential migration using cell-axon interactions namespace: biological_process def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021825 name: substrate-dependent cerebral cortex tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0006929 ! substrate-dependent cell migration is_a: GO:0021800 ! cerebral cortex tangential migration [Term] id: GO:0021826 name: substrate-independent telencephalic tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0021827 name: postnatal olfactory bulb interneuron migration namespace: biological_process def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021828 name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus namespace: biological_process alt_id: GO:0021857 def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "gonadotropin-releasing hormone neuronal migration to the hypothalamus" EXACT [GOC:dph] is_a: GO:0001764 ! neuron migration is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development [Term] id: GO:0021829 name: oligodendrocyte cell migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0021830 name: interneuron migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021831 name: embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021832 name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021833 name: cell-matrix adhesion involved in tangential migration using cell-cell interactions namespace: biological_process def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021834 name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021835 name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021836 name: chemorepulsion involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021837 name: motogenic signaling involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021838 name: motogenic signaling involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021839 name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021840 name: directional guidance of interneurons involved in migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021841 name: chemoattraction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021842 name: chemorepulsion involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021843 name: substrate-independent telencephalic tangential interneuron migration namespace: biological_process def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration [Term] id: GO:0021844 name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0042330 ! taxis relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021845 name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021846 name: cell proliferation in forebrain namespace: biological_process def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021847 name: ventricular zone neuroblast division namespace: biological_process def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in ventricular zone" EXACT [] is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division is_a: GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021848 name: neuroblast division in subpallium namespace: biological_process def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021849 name: neuroblast division in subventricular zone namespace: biological_process def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021850 name: subpallium glioblast cell division namespace: biological_process def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in subpallium" EXACT [] synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021851 name: neuroblast division in dorsal lateral ganglionic eminence namespace: biological_process def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021848 ! neuroblast division in subpallium [Term] id: GO:0021852 name: pyramidal neuron migration namespace: biological_process def: "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "projection neuron migration" RELATED [PMID:12626695] is_a: GO:0001764 ! neuron migration is_a: GO:0021801 ! cerebral cortex radial glia guided migration relationship: part_of GO:0021860 ! pyramidal neuron development [Term] id: GO:0021853 name: cerebral cortex GABAergic interneuron migration namespace: biological_process def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex is_a: GO:1904936 ! interneuron migration relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development [Term] id: GO:0021854 name: hypothalamus development namespace: biological_process def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021855 name: hypothalamus cell migration namespace: biological_process def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021856 name: hypothalamic tangential migration using cell-axon interactions namespace: biological_process def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021855 ! hypothalamus cell migration [Term] id: GO:0021858 name: GABAergic neuron differentiation in basal ganglia namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0097154 ! GABAergic neuron differentiation [Term] id: GO:0021859 name: pyramidal neuron differentiation namespace: biological_process def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron differentiation" BROAD [PMID:16226447] is_a: GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021860 name: pyramidal neuron development namespace: biological_process def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron development" BROAD [PMID:16226447] is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021859 ! pyramidal neuron differentiation [Term] id: GO:0021861 name: forebrain radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in forebrain" EXACT [] is_a: GO:0060019 ! radial glial cell differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021862 name: early neuron differentiation in forebrain namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021863 name: forebrain neuroblast differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] is_a: GO:0014016 ! neuroblast differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021864 name: obsolete radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021865 name: obsolete symmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021866 name: obsolete asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021867 name: obsolete neuron-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021868 name: obsolete ventricular zone cell-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021869 name: forebrain ventricular zone progenitor cell division namespace: biological_process def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021870 name: Cajal-Retzius cell differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021895 ! cerebral cortex neuron differentiation [Term] id: GO:0021871 name: forebrain regionalization namespace: biological_process def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021872 name: forebrain generation of neurons namespace: biological_process def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "generation of neurons in forebrain" EXACT [] is_a: GO:0048699 ! generation of neurons relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021873 name: forebrain neuroblast division namespace: biological_process def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0055057 ! neuroblast division relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021874 name: Wnt signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in forebrain neuroblast division" EXACT [] synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT [] synonym: "Wnt-activated signaling pathway involved in forebrain neuroblast division" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021875 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021876 name: Notch signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021877 name: forebrain neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021878 name: forebrain astrocyte fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0060018 ! astrocyte fate commitment relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021879 name: forebrain neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021880 name: Notch signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021881 name: Wnt-activated signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "Wnt-activated signaling pathway involved in forebrain neuron fate commitment" RELATED [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021882 name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021883 name: cell cycle arrest of committed forebrain neuronal progenitor cell namespace: biological_process def: "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0007050 ! cell cycle arrest is_a: GO:0007406 ! negative regulation of neuroblast proliferation is_a: GO:1904676 ! negative regulation of somatic stem cell division relationship: negatively_regulates GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021884 name: forebrain neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021885 name: forebrain cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021886 name: hypothalamus gonadotrophin-releasing hormone neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron differentiation" EXACT [GOC:dph] is_a: GO:0021979 ! hypothalamus cell differentiation [Term] id: GO:0021887 name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron fate commitment" RELATED [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021888 name: hypothalamus gonadotrophin-releasing hormone neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron development" RELATED [GOC:dph] is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021889 name: olfactory bulb interneuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0021890 name: olfactory bulb interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021891 name: olfactory bulb interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021892 name: cerebral cortex GABAergic interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021895 ! cerebral cortex neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation [Term] id: GO:0021893 name: cerebral cortex GABAergic interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021894 name: cerebral cortex GABAergic interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021895 name: cerebral cortex neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021896 name: forebrain astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048708 ! astrocyte differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021897 name: forebrain astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0014002 ! astrocyte development relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021898 name: commitment of multipotent stem cells to neuronal lineage in forebrain namespace: biological_process def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021899 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021900 name: ventricular zone cell fate commitment namespace: biological_process def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021863 ! forebrain neuroblast differentiation [Term] id: GO:0021901 name: early neuron fate commitment in forebrain namespace: biological_process def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021862 ! early neuron differentiation in forebrain [Term] id: GO:0021902 name: commitment of neuronal cell to specific neuron type in forebrain namespace: biological_process def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021904 name: dorsal/ventral neural tube patterning namespace: biological_process def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph] synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021907 name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0021512 ! spinal cord anterior/posterior patterning relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021908 name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0021512 ! spinal cord anterior/posterior patterning relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021909 name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021910 name: smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021911 name: retinoic acid metabolic process in spinal cord anterior-posterior patterning namespace: biological_process def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021912 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021913 name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0021521 ! ventral spinal cord interneuron specification relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021914 name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW [] synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0045879 ! negative regulation of smoothened signaling pathway is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0021916 name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors namespace: biological_process def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT [] is_a: GO:0031129 ! inductive cell-cell signaling relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021917 name: somatic motor neuron fate commitment namespace: biological_process def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021918 name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0021917 ! somatic motor neuron fate commitment relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021919 name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah] synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah] synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0021513 ! spinal cord dorsal/ventral patterning relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021920 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0021519 ! spinal cord association neuron specification relationship: part_of GO:0021519 ! spinal cord association neuron specification [Term] id: GO:0021921 name: regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010456 ! cell proliferation in dorsal spinal cord relationship: part_of GO:0021516 ! dorsal spinal cord development relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord [Term] id: GO:0021922 name: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] synonym: "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord [Term] id: GO:0021923 name: cell proliferation in hindbrain ventricular zone namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021924 name: cell proliferation in external granule layer namespace: biological_process def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021925 name: cerebellar Purkinje cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021926 name: Golgi cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021927 name: deep nuclear neuron precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021928 name: basket cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021929 name: stellate cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021930 name: cerebellar granule cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021931 name: rostral hindbrain neuronal precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021932 name: hindbrain radial glia guided cell migration namespace: biological_process def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021933 name: radial glia guided migration of cerebellar granule cell namespace: biological_process def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021934 name: hindbrain tangential cell migration namespace: biological_process def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725] is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021935 name: cerebellar granule cell precursor tangential migration namespace: biological_process def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021936 name: regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0051960 ! regulation of nervous system development is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0021930 ! cerebellar granule cell precursor proliferation relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021937 name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation namespace: biological_process def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0021940 ! positive regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021938 name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [Term] id: GO:0021939 name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation namespace: biological_process def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT [] is_a: GO:0035426 ! extracellular matrix-cell signaling relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021940 name: positive regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "activation of granule cell precursor proliferation" NARROW [] synonym: "stimulation of granule cell precursor proliferation" NARROW [] synonym: "up regulation of granule cell precursor proliferation" EXACT [] synonym: "up-regulation of granule cell precursor proliferation" EXACT [] synonym: "upregulation of granule cell precursor proliferation" EXACT [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021941 name: negative regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "down regulation of granule cell precursor proliferation" EXACT [] synonym: "down-regulation of granule cell precursor proliferation" EXACT [] synonym: "downregulation of granule cell precursor proliferation" EXACT [] synonym: "inhibition of granule cell precursor proliferation" NARROW [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021942 name: radial glia guided migration of Purkinje cell namespace: biological_process def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021943 name: formation of radial glial scaffolds namespace: biological_process def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725] synonym: "Bergmann fiber formation" RELATED [PMID:15157725] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021944 name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration namespace: biological_process def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021945 name: positive regulation of cerebellar granule cell migration by calcium namespace: biological_process def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "calcium-mediated activation of granule cell migration" NARROW [] synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb] synonym: "calcium-mediated stimulation of granule cell migration" NARROW [] synonym: "calcium-mediated up regulation of granule cell migration" EXACT [] synonym: "calcium-mediated up-regulation of granule cell migration" EXACT [] synonym: "calcium-mediated upregulation of granule cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0030335 ! positive regulation of cell migration relationship: part_of GO:0021933 ! radial glia guided migration of cerebellar granule cell [Term] id: GO:0021946 name: deep nuclear neuron cell migration namespace: biological_process def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021947 name: outward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021948 name: inward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021949 name: brainstem precerebellar neuron precursor migration namespace: biological_process def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021950 name: chemorepulsion involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021951 name: chemoattraction involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021952 name: central nervous system projection neuron axonogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "central nervous system axon tract development" NARROW [GOC:dph] is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048666 ! neuron development relationship: part_of GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021955 name: central nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0021954 ! central nervous system neuron development [Term] id: GO:0021956 name: central nervous system interneuron axonogenesis namespace: biological_process def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021957 name: corticospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021958 name: gracilis tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021959 name: cuneatus tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021960 name: anterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021961 name: posterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021962 name: vestibulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021963 name: spinothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT [] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021964 name: rubrospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021965 name: spinal cord ventral commissure morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021966 name: corticospinal neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021957 ! corticospinal tract morphogenesis [Term] id: GO:0021967 name: corticospinal neuron axon guidance through the cerebral cortex namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021968 name: corticospinal neuron axon guidance through the internal capsule namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021969 name: corticospinal neuron axon guidance through the cerebral peduncle namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021970 name: corticospinal neuron axon guidance through the basilar pons namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021971 name: corticospinal neuron axon guidance through the medullary pyramid namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021972 name: corticospinal neuron axon guidance through spinal cord namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021973 name: corticospinal neuron axon decussation namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. is_a: GO:0016199 ! axon midline choice point recognition relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021974 name: trigeminothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021975 name: pons reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021976 name: medulla reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021977 name: tectospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021978 name: telencephalon regionalization namespace: biological_process def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021979 name: hypothalamus cell differentiation namespace: biological_process def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021980 name: subpallium cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021981 name: subpallium radially oriented migration namespace: biological_process def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021980 ! subpallium cell migration [Term] id: GO:0021982 name: pineal gland development namespace: biological_process def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epiphysis development" EXACT [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021983 name: pituitary gland development namespace: biological_process def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hypophysis development" RELATED [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021984 name: adenohypophysis development namespace: biological_process def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "adenophysis development" EXACT [] synonym: "anterior pituitary development" EXACT [] synonym: "anterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021985 name: neurohypophysis development namespace: biological_process def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neurophysis development" EXACT [] synonym: "posterior pituitary development" EXACT [] synonym: "posterior pituitary gland development" EXACT [] is_a: GO:0048732 ! gland development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021986 name: habenula development namespace: biological_process def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:9780721601465] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021538 ! epithalamus development [Term] id: GO:0021987 name: cerebral cortex development namespace: biological_process def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839] synonym: "neocortex development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0021988 name: olfactory lobe development namespace: biological_process def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021989 name: olfactory cortex development namespace: biological_process def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021991 name: neural plate thickening namespace: biological_process def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021992 name: cell proliferation involved in neural plate elongation namespace: biological_process def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0014022 ! neural plate elongation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0021993 name: initiation of neural tube closure namespace: biological_process def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021994 name: progression of neural tube closure namespace: biological_process def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021995 name: neuropore closure namespace: biological_process def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021996 name: lamina terminalis formation namespace: biological_process def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021506 ! anterior neuropore closure [Term] id: GO:0021997 name: neural plate axis specification namespace: biological_process def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification relationship: part_of GO:0001840 ! neural plate development relationship: part_of GO:0060896 ! neural plate pattern specification [Term] id: GO:0021998 name: neural plate mediolateral regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph] is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0022000 name: forebrain induction by the anterior neural ridge namespace: biological_process def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0031128 ! developmental induction relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022001 name: negative regulation of anterior neural cell fate commitment of the neural plate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "caudalization of neural plate" EXACT [] synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "posteriorization" BROAD [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0051961 ! negative regulation of nervous system development relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022002 name: negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate [Term] id: GO:0022003 name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate is_a: GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:0022004 name: midbrain-hindbrain boundary maturation during brain development namespace: biological_process def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022005 name: midbrain-hindbrain boundary maturation during neural plate development namespace: biological_process def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" RELATED [GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022006 name: zona limitans intrathalamica formation namespace: biological_process def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095] comment: This term was added by GO_REF:0000021. synonym: "zli biosynthesis" EXACT [] synonym: "zli formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0022007 name: convergent extension involved in neural plate elongation namespace: biological_process def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0014022 ! neural plate elongation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001570 ! vasculogenesis relationship: part_of GO:0014045 ! establishment of endothelial blood-brain barrier [Term] id: GO:0022010 name: central nervous system myelination namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "myelination in central nervous system" EXACT [] is_a: GO:0032291 ! axon ensheathment in central nervous system is_a: GO:0042552 ! myelination relationship: part_of GO:0014003 ! oligodendrocyte development [Term] id: GO:0022011 name: myelination in peripheral nervous system namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "peripheral nervous system myelination" EXACT [] is_a: GO:0032292 ! peripheral nervous system axon ensheathment is_a: GO:0042552 ! myelination relationship: part_of GO:0014044 ! Schwann cell development [Term] id: GO:0022012 name: subpallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0022013 name: pallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0022014 name: obsolete radial glial cell division in subpallium namespace: biological_process def: "OBSOLETE. The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0022015 name: radial glial cell division in pallium namespace: biological_process def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022016 name: pallium glioblast division namespace: biological_process def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in pallium" EXACT [] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022017 name: neuroblast division in pallium namespace: biological_process def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022018 name: lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022019 name: dorsal lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation [Term] id: GO:0022020 name: medial ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022021 name: caudal ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022022 name: septal cell proliferation namespace: biological_process def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "septum cell proliferation" EXACT [] is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022023 name: radial glial cell fate commitment in forebrain namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation [Term] id: GO:0022024 name: BMP signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0021882 ! regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0022025 name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:signaling] comment: This term was added by GO_REF:0000021. synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway intersection_of: GO:0048861 ! leukemia inhibitory factor signaling pathway intersection_of: part_of GO:0021877 ! forebrain neuron fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022026 name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022027 name: interkinetic nuclear migration namespace: biological_process def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0022028 name: tangential migration from the subventricular zone to the olfactory bulb namespace: biological_process def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rostral migratory stream migration" EXACT [] is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0022029 name: telencephalon cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021885 ! forebrain cell migration relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022030 name: telencephalon glial cell migration namespace: biological_process def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0008347 ! glial cell migration is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0022031 name: telencephalon astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration is_a: GO:0043615 ! astrocyte cell migration [Term] id: GO:0022032 name: telencephalon oligodendrocyte cell migration namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022033 name: telencephalon microglial cell migration namespace: biological_process def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022034 name: rhombomere cell proliferation namespace: biological_process def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15629700] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022036 name: rhombomere cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0022038 name: corpus callosum development namespace: biological_process def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022400 name: regulation of rhodopsin mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] synonym: "regulation of rhodopsin mediated signalling" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016056 ! rhodopsin mediated signaling pathway relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0022401 name: negative adaptation of signaling pathway namespace: biological_process def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete] synonym: "negative adaptation of signal transduction pathway" EXACT [] synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022404 name: molting cycle process namespace: biological_process def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042303 ! molting cycle [Term] id: GO:0022405 name: hair cycle process namespace: biological_process def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0042633 ! hair cycle [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir synonym: "membrane docking" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098609 ! cell-cell adhesion relationship: regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098609 ! cell-cell adhesion relationship: negatively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098609 ! cell-cell adhesion relationship: positively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022410 name: circadian sleep/wake cycle process namespace: biological_process def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0032504 ! multicellular organism reproduction relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0022413 name: reproductive process in single-celled organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032505 ! reproduction of a single-celled organism [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] synonym: "single organism reproductive process" RELATED [] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0000003 ! reproduction disjoint_from: GO:0044848 ! biological phase relationship: part_of GO:0000003 ! reproduction created_by: janelomax creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022416 name: chaeta development namespace: biological_process def: "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] synonym: "bristle development" NARROW [GOC:bf, GOC:dos] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0022417 name: protein maturation by protein folding namespace: biological_process def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete] is_a: GO:0006457 ! protein folding is_a: GO:0051604 ! protein maturation [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: part_of GO:0007586 ! digestion relationship: part_of GO:0007586 ! digestion [Term] id: GO:0022601 name: menstrual cycle phase namespace: biological_process def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022602 name: ovulation cycle process namespace: biological_process def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] synonym: "estrous cycle process" RELATED [] synonym: "menstrual cycle process" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:0048511 ! rhythmic process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0042698 ! ovulation cycle relationship: part_of GO:0042698 ! ovulation cycle [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis relationship: regulates GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000902 ! cell morphogenesis relationship: regulates GO:0000902 ! cell morphogenesis [Term] id: GO:0022605 name: mammalian oogenesis stage namespace: biological_process def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] synonym: "mammalian oogenesis process" EXACT [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0022606 name: establishment of proximal/distal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete] is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022608 name: multicellular organism adhesion namespace: biological_process def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete] is_a: GO:0022610 ! biological adhesion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0022609 name: multicellular organism adhesion to substrate namespace: biological_process def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete] is_a: GO:0022608 ! multicellular organism adhesion [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] subset: goslim_pir is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0022611 name: dormancy process namespace: biological_process def: "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009] comment: In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium. synonym: "multicellular organism dormancy process" NARROW [] synonym: "spore dormancy process" NARROW [GOC:PO_curators] is_a: GO:0032502 ! developmental process [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048732 ! gland development [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022614 name: membrane to membrane docking namespace: biological_process def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete] synonym: "membrane-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022615 name: protein to membrane docking namespace: biological_process def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] synonym: "protein-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022616 name: DNA strand elongation namespace: biological_process def: "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0071897 ! DNA biosynthetic process [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0022618 name: ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic synonym: "protein-RNA complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0022619 name: generative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022620 name: vegetative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete] synonym: "tube cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022622 name: root system development namespace: biological_process def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete] is_a: GO:0048731 ! system development [Term] id: GO:0022623 name: proteasome-activating nucleotidase complex namespace: cellular_component def: "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528] synonym: "PAN" EXACT [PMID:19363223, PMID:19481528] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0022624 name: proteasome accessory complex namespace: cellular_component def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0022625 name: cytosolic large ribosomal subunit namespace: cellular_component alt_id: GO:0005842 alt_id: GO:0009282 alt_id: GO:0030498 alt_id: GO:0030872 def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "50S ribosomal subunit" NARROW [] synonym: "60S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal LSU" NARROW [] synonym: "prokaryotic large ribosomal subunit" NARROW [] is_a: GO:0015934 ! large ribosomal subunit intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0022626 ! cytosolic ribosome relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component alt_id: GO:0005830 alt_id: GO:0009281 alt_id: GO:0030871 def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0022627 name: cytosolic small ribosomal subunit namespace: cellular_component alt_id: GO:0005843 alt_id: GO:0009283 alt_id: GO:0030499 alt_id: GO:0030873 def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "30S ribosomal subunit" NARROW [] synonym: "40S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal SSU" NARROW [] synonym: "prokaryotic small ribosomal subunit" NARROW [] is_a: GO:0015935 ! small ribosomal subunit intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0022626 ! cytosolic ribosome relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022628 name: chloroplast large ribosomal subunit namespace: cellular_component def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal large subunit complex" EXACT [] synonym: "chloroplast ribosomal LSU complex" EXACT [] is_a: GO:0000311 ! plastid large ribosomal subunit intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0043253 ! chloroplast ribosome relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022629 name: chloroplast small ribosomal subunit namespace: cellular_component def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal small subunit complex" EXACT [] synonym: "chloroplast ribosomal SSU complex" EXACT [] is_a: GO:0000312 ! plastid small ribosomal subunit intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0043253 ! chloroplast ribosome relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022803 name: passive transmembrane transporter activity namespace: molecular_function alt_id: GO:0022814 def: "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "facilitated diffusion" RELATED [] synonym: "porters" BROAD [] synonym: "uniporter activity z" NARROW [] xref: Reactome:R-HSA-429767 "Passive I- efflux mediated by SMCT1" xref: Wikipedia:Facilitated_diffusion is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022809 name: mobile ion carrier activity namespace: molecular_function def: "Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "ionophore" BROAD [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0034220 ! ion transmembrane transport [Term] id: GO:0022810 name: membrane potential driven uniporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porter" BROAD [] is_a: GO:0015292 ! uniporter activity [Term] id: GO:0022815 name: obsolete large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. synonym: "large uncharged polar molecule transmembrane transporter activity" EXACT [] is_obsolete: true replaced_by: GO:0022857 [Term] id: GO:0022818 name: sodium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0022819 name: potassium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0022821 name: potassium ion antiporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0022824 name: transmitter-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity is_a: GO:0022835 ! transmitter-gated channel activity [Term] id: GO:0022825 name: obsolete copper-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined. synonym: "copper-exporting ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0043682 [Term] id: GO:0022828 name: phosphorylation-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022829 name: wide pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] synonym: "gap junction activity" NARROW [] synonym: "non-gated, wide pore channel activity" EXACT [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022831 name: narrow pore, gated channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] synonym: "ion channels" RELATED [] xref: Wikipedia:Ion_channels is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022832 name: voltage-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022834 name: ligand-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022835 name: transmitter-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular substance gated channel activity" EXACT [] synonym: "neurotransmitter-gated channel activity" EXACT [] is_a: GO:0022834 ! ligand-gated channel activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0022836 name: gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] is_a: GO:0015267 ! channel activity [Term] id: GO:0022839 name: ion gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022840 name: leak channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022841 name: potassium ion leak channel activity namespace: molecular_function def: "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022840 ! leak channel activity [Term] id: GO:0022842 name: narrow pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015267 ! channel activity [Term] id: GO:0022843 name: voltage-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-2534378 "Hv1 Mediated H+ Permeability" xref: Reactome:R-HSA-6788999 "HV1-mediated H+ transfer" is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0022848 name: acetylcholine-gated cation-selective channel activity namespace: molecular_function alt_id: GO:0004889 alt_id: GO:0016904 def: "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] synonym: "acetylcholine-activated cation-selective channel activity" EXACT [] synonym: "acetylcholine-gated cation channel activity" EXACT [] synonym: "ionotropic acetylcholine receptor activity" EXACT [] synonym: "nAChR" EXACT [] synonym: "nicotinergic acetylcholine receptor activity" EXACT [] synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity is_a: GO:1904315 ! transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential [Term] id: GO:0022849 name: glutamate-gated calcium ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0099604 ! ligand-gated calcium channel activity [Term] id: GO:0022850 name: serotonin-gated cation-selective channel activity namespace: molecular_function alt_id: GO:0005232 def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW [] synonym: "serotonin-activated cation-selective channel activity" EXACT [] synonym: "serotonin-gated cation channel activity" NARROW [] xref: Reactome:R-HSA-975311 "HTR3 pentamer:5HT transports Na+,K+, and Ca2+" is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity relationship: part_of GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0022851 name: GABA-gated chloride ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0016917 ! GABA receptor activity is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0022852 name: glycine-gated chloride ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0022853 name: active ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0022854 name: obsolete active large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. synonym: "active large uncharged polar molecule transmembrane transporter activity" EXACT [] is_obsolete: true replaced_by: GO:0022804 [Term] id: GO:0022855 name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "glucose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022856 name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015576 ! sorbitol transmembrane transporter activity [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport [Term] id: GO:0022858 name: alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:0032328 ! alanine transport [Term] id: GO:0022859 name: dephosphorylation-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022865 name: obsolete transmembrane electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. xref: TC:5 is_obsolete: true [Term] id: GO:0022866 name: obsolete transmembrane 1-electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0022867 name: obsolete transmembrane 2-electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0022869 name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "lactose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0022870 name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015578 ! mannose transmembrane transporter activity [Term] id: GO:0022871 name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019194 ! sorbose transmembrane transporter activity [Term] id: GO:0022872 name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015575 ! mannitol transmembrane transporter activity [Term] id: GO:0022873 name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "maltose PTS transporter activity" EXACT [] is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022874 name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "cellobiose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019191 ! cellobiose transmembrane transporter activity [Term] id: GO:0022875 name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015577 ! galactitol transmembrane transporter activity [Term] id: GO:0022876 name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019196 ! galactosamine transmembrane transporter activity [Term] id: GO:0022877 name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "fructose PTS transporter activity" EXACT [] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022878 name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sucrose PTS transporter activity" EXACT [] xref: MetaCyc:SUCROSEPHOSPHO-RXN is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022879 name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "trehalose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022880 name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022881 name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity [Term] id: GO:0022882 name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "beta-glucoside PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity [Term] id: GO:0022883 name: zinc efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "zinc efflux permease activity" EXACT [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity is_a: GO:0046583 ! cation efflux transmembrane transporter activity [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022885 name: bacteriocin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a bacteriocin from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0043213 ! bacteriocin transport [Term] id: GO:0022886 name: channel-forming ionophore activity namespace: molecular_function def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore activity" BROAD [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022889 name: serine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:0032329 ! serine transport [Term] id: GO:0022890 name: inorganic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015082 def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0022893 name: low-affinity tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0015510 def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low-affinity tryptophan permease activity" RELATED [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0022894 name: Intermediate conductance calcium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "IK calcium-activated potassium channel activity" EXACT [] synonym: "IK KCa channels" EXACT [] synonym: "intermdiate conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0022897 name: proton-dependent peptide secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] synonym: "hydrogen/oligopeptide symporter" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity relationship: part_of GO:1902600 ! proton transmembrane transport [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022857 ! transmembrane transporter activity relationship: regulates GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022900 name: electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] subset: goslim_pir xref: Wikipedia:Electron_transport_chain is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0022904 name: respiratory electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] xref: Wikipedia:Electron_transfer is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0045333 ! cellular respiration [Term] id: GO:0023002 name: nuclear migration to embryo sac poles namespace: biological_process def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to female gametophyte poles" EXACT [] synonym: "nuclear migration to megagametophyte poles" EXACT [] synonym: "nucleus migration to embryo sac poles" EXACT [] synonym: "nucleus migration to female gametophyte poles" EXACT [] synonym: "nucleus migration to megagametophyte poles" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023003 name: nuclear migration to the embryo sac center namespace: biological_process def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to the embryo sac centre" EXACT [] synonym: "nuclear migration to the female gametophyte center" EXACT [] synonym: "nuclear migration to the female gametophyte centre" EXACT [] synonym: "nuclear migration to the megagametophyte center" EXACT [] synonym: "nuclear migration to the megagametophyte centre" EXACT [] synonym: "nucleus migration to the female gametophyte center" EXACT [] synonym: "nucleus migration to the female gametophyte centre" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023004 name: obsolete activation of dopamine receptor signaling pathway namespace: biological_process def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "activation of dopamine receptor signaling pathway" EXACT [] synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "initiation of dopamine receptor signaling pathway" RELATED [] synonym: "stimulation of dopamine receptor signaling pathway" EXACT [] is_obsolete: true consider: GO:0060161 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023005 name: obsolete signal initiation by neurotransmitter namespace: biological_process def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by neurotransmitter" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0030594 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023006 name: obsolete signal initiation by amino acid namespace: biological_process def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by amino acid" EXACT [] is_obsolete: true consider: GO:0007215 consider: GO:0008066 consider: GO:0071230 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023007 name: obsolete ligand binding to T cell receptor namespace: biological_process def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. synonym: "ligand binding to T cell receptor" EXACT [] is_obsolete: true consider: GO:0042101 consider: GO:0042608 consider: GO:0050852 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023009 name: obsolete initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "initiation of T cell receptor signaling" EXACT [] synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0038023 consider: GO:0042101 consider: GO:0048018 consider: GO:0050852 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023010 name: obsolete regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "regulation of initiation of T cell receptor signaling" EXACT [] synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050856 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023011 name: obsolete positive regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "positive regulation of initiation of T cell receptor signaling" EXACT [] synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050862 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023012 name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor namespace: biological_process def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. synonym: "initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor" EXACT [] synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah] is_obsolete: true consider: GO:0042101 consider: GO:0050852 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023014 name: signal transduction by protein phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0007165 ! signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023015 name: signal transduction by cis-phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules." [GOC:bf, GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via a cis-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via a cis-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via auto-phosphorylation" RELATED [] is_a: GO:0023014 ! signal transduction by protein phosphorylation creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023016 name: signal transduction by trans-phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal." [GOC:bf, GOC:mtg_signal] synonym: "signal transduction via a trans-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via a trans-phosphorylation event" RELATED [GOC:bf] is_a: GO:0023014 ! signal transduction by protein phosphorylation creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023017 name: obsolete signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via diffusible molecule" EXACT [] synonym: "signaling via diffusible mediator" EXACT [] is_obsolete: true consider: GO:0007267 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023018 name: obsolete T cell activation of signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "T cell activation of signal transmission via diffusible molecule" EXACT [] is_obsolete: true creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0010468 ! regulation of gene expression relationship: part_of GO:0010468 ! regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023020 name: obsolete regulation of gene expression as a consequence of T cell signal transmission namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "regulation of gene expression as a consequence of T cell signal transmission" EXACT [] is_obsolete: true consider: GO:0023019 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023021 name: termination of signal transduction namespace: biological_process def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. is_a: GO:0009968 ! negative regulation of signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023022 name: termination of T cell signal transduction namespace: biological_process def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway relationship: part_of GO:0050852 ! T cell receptor signaling pathway creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023023 name: MHC protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023024 name: MHC class I protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023025 name: MHC class Ib protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023026 name: MHC class II protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023027 name: MHC class I protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] is_a: GO:0042288 ! MHC class I protein binding relationship: part_of GO:0023024 ! MHC class I protein complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023028 name: MHC class I protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] is_a: GO:0042288 ! MHC class I protein binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023029 name: MHC class Ib protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw] is_a: GO:0042287 ! MHC protein binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023030 name: MHC class Ib protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] is_a: GO:0023029 ! MHC class Ib protein binding relationship: part_of GO:0023025 ! MHC class Ib protein complex binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023031 name: MHC class Ib protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] is_a: GO:0023029 ! MHC class Ib protein binding creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023035 name: CD40 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017] synonym: "CD40 signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023036 name: obsolete initiation of signal transduction namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors. synonym: "initiation of signal transduction" EXACT [] synonym: "signal reception" RELATED [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0048018 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023037 name: obsolete signal initiation by light namespace: biological_process def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by light" EXACT [] is_obsolete: true consider: GO:0009785 consider: GO:0009881 consider: GO:0010017 consider: GO:0010018 consider: GO:0010161 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023038 name: obsolete signal initiation by diffusible mediator namespace: biological_process def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by diffusible mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038001 consider: GO:0038023 consider: GO:0048018 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023039 name: obsolete signal initiation by physical damage namespace: biological_process def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by physical damage" EXACT [] is_obsolete: true consider: GO:0033554 consider: GO:0038023 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023040 name: obsolete signaling via ionic flux namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via ionic flux" EXACT [] synonym: "signalling via ionic flux" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023041 name: neuronal signal transduction namespace: biological_process def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal] is_a: GO:0007165 ! signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023042 name: obsolete signaling via protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via protein/peptide mediator" EXACT [] synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023043 name: obsolete signaling via lipid mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via lipid mediator" EXACT [] synonym: "signalling via lipid mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0014065 consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023044 name: obsolete signaling via chemical mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via chemical mediator" EXACT [] synonym: "signalling via chemical mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023045 name: signal transduction by conformational transition namespace: biological_process def: "A process where induction of a conformational change in a molecule transmits a signal to that molecule." [GOC:bf, GOC:mtg_signal] synonym: "signal transduction via conformational transition" RELATED [GOC:bf] synonym: "signal transmission via conformational transition" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023047 name: obsolete signal initiation by chemical mediator namespace: biological_process def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by chemical mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0070887 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023048 name: obsolete signal initiation by lipid mediator namespace: biological_process def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by lipid mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0045125 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023049 name: obsolete signal initiation by protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by protein/peptide mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0048018 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023050 name: obsolete consequence of signal transmission namespace: biological_process def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal] comment: This term was made obsolete because the term is no longer needed. synonym: "consequence of signal transmission" EXACT [] synonym: "signal termination" EXACT [] is_obsolete: true creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0023052 ! signaling relationship: regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pombe subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023053 name: obsolete signal initiation by mechanical effect namespace: biological_process def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by mechanical effect" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0071260 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023054 name: obsolete signal initiation by stretch effect namespace: biological_process def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by stretch effect" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023055 name: obsolete signal initiation by peptide hormone namespace: biological_process def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by peptide hormone" EXACT [] is_obsolete: true consider: GO:0004879 consider: GO:0005179 consider: GO:0009755 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0023052 ! signaling relationship: positively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0023052 ! signaling relationship: negatively_regulates GO:0023052 ! signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023058 name: adaptation of signaling pathway namespace: biological_process def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023059 name: positive adaptation of signaling pathway namespace: biological_process def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023060 name: obsolete signal transmission namespace: biological_process def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "signal transmission" EXACT [] is_obsolete: true consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: GO:0032940 ! secretion by cell intersection_of: GO:0032940 ! secretion by cell intersection_of: part_of GO:0007267 ! cell-cell signaling relationship: part_of GO:0007267 ! cell-cell signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023062 name: obsolete signal transmission via transcytosis namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via transcytosis" EXACT [] is_obsolete: true consider: GO:0023052 consider: GO:0045056 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023065 name: obsolete signal transmission via blood namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via blood" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023066 name: obsolete signal transmission via vascular system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via vascular system" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023067 name: obsolete signal transmission via lymphatic system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via lymphatic system" EXACT [] is_obsolete: true consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023068 name: obsolete signal transmission via phloem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via phloem" EXACT [] is_obsolete: true consider: GO:0010233 consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023069 name: obsolete signal transmission via xylem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via xylem" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023070 name: obsolete signal transmission via air namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via air" EXACT [] is_obsolete: true creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030001 name: metal ion transport namespace: biological_process def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "heavy metal ion transport" NARROW [] is_a: GO:0006812 ! cation transport [Term] id: GO:0030002 name: cellular anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah] xref: MIPS_funcat:34.01.03 is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0030003 name: cellular cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah] xref: MIPS_funcat:34.01.01 is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0030004 name: cellular monovalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0030005 name: obsolete cellular di-, tri-valent inorganic cation homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah] synonym: "cellular di-, tri-valent inorganic cation homeostasis" EXACT [] is_obsolete: true consider: GO:0072503 consider: GO:0072504 [Term] id: GO:0030006 name: obsolete heavy cellular metal ion homeostasis namespace: biological_process def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy cellular metal ion homeostasis" EXACT [] is_obsolete: true consider: GO:0006875 [Term] id: GO:0030007 name: cellular potassium ion homeostasis namespace: biological_process alt_id: GO:0017079 def: "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055075 ! potassium ion homeostasis [Term] id: GO:0030008 name: TRAPP complex namespace: cellular_component def: "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257] synonym: "transport protein particle" EXACT [] synonym: "transport protein particle complex" EXACT [GOC:bhm] synonym: "TRAPP1" NARROW [GOC:vw] synonym: "TRAPP2" NARROW [GOC:vw] xref: Wikipedia:TRAPP_complex is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030009 name: obsolete complement factor H activity namespace: molecular_function def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "complement factor H activity" EXACT [] is_obsolete: true consider: GO:0006956 [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process alt_id: GO:0000283 alt_id: GO:0030468 def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030011 name: maintenance of cell polarity namespace: biological_process alt_id: GO:0030013 alt_id: GO:0030469 def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030014 name: CCR4-NOT complex namespace: cellular_component def: "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030015 name: CCR4-NOT core complex namespace: cellular_component def: "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030014 ! CCR4-NOT complex [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] synonym: "striated muscle fiber" RELATED [] synonym: "striated muscle fibre" RELATED [] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile fiber [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0030018 name: Z disc namespace: cellular_component def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] synonym: "Z band" EXACT [] synonym: "Z disk" EXACT [] synonym: "Z line" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031674 ! I band [Term] id: GO:0030019 name: obsolete tryptase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59] comment: This term was made obsolete because it represents a gene product. synonym: "lung tryptase activity" NARROW [EC:3.4.21.59] synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59] synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59] synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59] synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59] synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59] synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] synonym: "tryptase activity" EXACT [] synonym: "tryptase M" RELATED [EC:3.4.21.59] xref: EC:3.4.21.59 xref: MetaCyc:3.4.21.59-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030020 name: extracellular matrix structural constituent conferring tensile strength namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030021 name: extracellular matrix structural constituent conferring compression resistance namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030022 name: obsolete adhesive extracellular matrix constituent namespace: molecular_function def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because it does not represent a molecular function. synonym: "adhesive extracellular matrix constituent" EXACT [] is_obsolete: true consider: GO:0030674 consider: GO:0031012 consider: GO:0050839 consider: GO:0050840 [Term] id: GO:0030023 name: extracellular matrix constituent conferring elasticity namespace: molecular_function def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix elastin proteins may be annotated to this term. PMID:27009176, PMID:24443019 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] synonym: "elastin" RELATED [] is_a: GO:0005201 ! extracellular matrix structural constituent is_a: GO:0097493 ! structural molecule activity conferring elasticity [Term] id: GO:0030026 name: cellular manganese ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah] synonym: "manganese homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055071 ! manganese ion homeostasis [Term] id: GO:0030027 name: lamellipodium namespace: cellular_component def: "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] xref: Wikipedia:Lamellipodia is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030032 name: lamellipodium assembly namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] synonym: "lamellipodium biogenesis" RELATED [GOC:mah] synonym: "lamellipodium biosynthesis" EXACT [] synonym: "lamellipodium formation" EXACT [] is_a: GO:0097581 ! lamellipodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030034 name: microvillar actin bundle assembly namespace: biological_process def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah] is_a: GO:0030046 ! parallel actin filament bundle assembly relationship: part_of GO:0030033 ! microvillus assembly [Term] id: GO:0030035 name: microspike assembly namespace: biological_process def: "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735] comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. For the assembly of filopodia, use 'filopodium assembly ; GO:0046847'. synonym: "microspike biogenesis" RELATED [GOC:mah] synonym: "microspike biosynthesis" EXACT [] synonym: "microspike formation" EXACT [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_drosophila subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] xref: MIPS_funcat:42.04.03 is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030037 name: actin filament reorganization involved in cell cycle namespace: biological_process def: "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] synonym: "actin filament reorganisation involved in cell cycle" EXACT [GOC:mah] synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb] xref: MIPS_funcat:10.03.05 xref: MIPS_funcat:10.03.05.03 is_a: GO:0022402 ! cell cycle process is_a: GO:0090527 ! actin filament reorganization intersection_of: GO:0090527 ! actin filament reorganization intersection_of: part_of GO:0007049 ! cell cycle [Term] id: GO:0030038 name: contractile actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030039 name: obsolete DNA unwinding factor namespace: molecular_function alt_id: GO:0017152 def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA unwinding factor" EXACT [] is_obsolete: true replaced_by: GO:0006268 [Term] id: GO:0030041 name: actin filament polymerization namespace: biological_process def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "actin polymerization" EXACT [] synonym: "actin polymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0030042 name: actin filament depolymerization namespace: biological_process def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "actin depolymerization" EXACT [] synonym: "actin depolymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0030043 name: actin filament fragmentation namespace: biological_process def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] is_a: GO:0030042 ! actin filament depolymerization [Term] id: GO:0030046 name: parallel actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030047 name: actin modification namespace: biological_process alt_id: GO:0007013 def: "Covalent modification of an actin molecule." [GOC:mah] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] xref: MIPS_funcat:20.09.14.02 is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030049 name: muscle filament sliding namespace: biological_process def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0033275 ! actin-myosin filament sliding relationship: part_of GO:0006936 ! muscle contraction [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking [Term] id: GO:0030051 name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase namespace: molecular_function def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "FK506 binding protein" RELATED [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" EXACT [] synonym: "FKBP" RELATED [] is_obsolete: true consider: GO:0003755 consider: GO:0005528 [Term] id: GO:0030052 name: obsolete parvulin namespace: molecular_function def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732] comment: This term was made obsolete because it describes a gene product. synonym: "parvulin" EXACT [] is_obsolete: true replaced_by: GO:0003755 [Term] id: GO:0030053 name: obsolete immunophilin namespace: molecular_function def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732] comment: This term was made obsolete because it does not represent a molecular function. synonym: "immunophilin" EXACT [] is_obsolete: true consider: GO:0003755 [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon xref: MIPS_funcat:70.06 xref: Wikipedia:Cell_junction is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0030055 name: cell-substrate junction namespace: cellular_component def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] synonym: "cell-matrix junction" EXACT [] is_a: GO:0070161 ! anchoring junction [Term] id: GO:0030056 name: hemidesmosome namespace: cellular_component def: "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] synonym: "epidermal attachment structure" NARROW [GOC:kmv] synonym: "fibrous organelle" NARROW [GOC:kmv, PMID:20205195] synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction] synonym: "trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195] xref: Wikipedia:Hemidesmosome is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0030057 name: desmosome namespace: cellular_component def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] synonym: "macula adherens" EXACT [] synonym: "spot desmosome" EXACT [] xref: Wikipedia:Desmosome is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0030058 name: amine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.9.1] synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.9.1] synonym: "MADH activity" EXACT [EC:1.4.9.1] synonym: "methylamine dehydrogenase activity" RELATED [EC:1.4.9.1] synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.9.1] synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.9.1] synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.9.1] xref: EC:1.4.9.1 xref: MetaCyc:AMINE-DEHYDROGENASE-RXN xref: RHEA:30207 xref: UM-BBD_enzymeID:e0058 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0030059 name: aralkylamine dehydrogenase (azurin) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde." [EC:1.4.9.2] synonym: "aralkylamine:(azurin) oxidoreductase (deaminating) activity" EXACT [EC:1.4.9.2] synonym: "aromatic amine dehydrogenase (azurin) activity" EXACT [EC:1.4.9.2] synonym: "arylamine dehydrogenase activity" BROAD [EC:1.4.9.2] synonym: "dehydrogenase, arylamine (azurin) activity" EXACT [EC:1.4.9.2] synonym: "tyramine dehydrogenase (azurin) activity" NARROW [EC:1.4.9.2] xref: EC:1.4.9.2 xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor [Term] id: GO:0030060 name: L-malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "MDH" RELATED [EC:1.1.1.37] synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-L-malate dehydrogenase activity" EXACT [] synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37] xref: EC:1.1.1.37 xref: MetaCyc:MALATE-DEH-RXN xref: Reactome:R-HSA-198508 "malate + NAD+ <=> oxaloacetate + NADH + H+" xref: Reactome:R-HSA-70979 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+" xref: Reactome:R-HSA-71783 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+" xref: RHEA:21432 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030061 name: mitochondrial crista namespace: cellular_component def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "cristae" BROAD [NIF_Subcellular:sao333328131] synonym: "mitochondrial cristae" EXACT [] xref: NIF_Subcellular:sao333328131 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0030062 name: mitochondrial tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] synonym: "TCA cycle enzyme complex" BROAD [] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0045239 ! tricarboxylic acid cycle enzyme complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0030063 name: obsolete murein sacculus namespace: cellular_component def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891] comment: This term was made obsolete because it was defined inaccurately. synonym: "murein sacculus" EXACT [] synonym: "peptidoglycan layer" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0030064 name: obsolete cell wall inner membrane namespace: cellular_component def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254] comment: This term was made obsolete because it was defined inaccurately. synonym: "cell wall inner membrane" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0030066 name: obsolete cytochrome b6 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b-563" RELATED [] synonym: "cytochrome b6" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0030067 name: obsolete respiratory chain cytochrome b6 namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "respiratory chain cytochrome b6" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0030068 name: obsolete lytic viral life cycle namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "lytic viral life cycle" EXACT [] is_obsolete: true consider: GO:0019058 consider: GO:0044659 [Term] id: GO:0030070 name: insulin processing namespace: biological_process def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732] is_a: GO:0016486 ! peptide hormone processing is_a: GO:1901142 ! insulin metabolic process [Term] id: GO:0030071 name: regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0030073 name: insulin secretion namespace: biological_process def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] comment: Updated definition, added taxon constraint https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030074 name: obsolete thylakoid (sensu Proteobacteria) namespace: cellular_component def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah] comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. synonym: "thylakoid (sensu Proteobacteria)" EXACT [] is_obsolete: true consider: GO:0042716 [Term] id: GO:0030075 name: bacterial thylakoid namespace: cellular_component def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane-derived thylakoid" EXACT [] is_a: GO:0009579 ! thylakoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0030076 name: light-harvesting complex namespace: cellular_component def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] subset: goslim_pir synonym: "antenna complex" RELATED [] xref: Wikipedia:Light-harvesting_complex is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030077 name: plasma membrane light-harvesting complex namespace: cellular_component def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030076 ! light-harvesting complex relationship: part_of GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0030078 name: light-harvesting complex, core complex namespace: cellular_component def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030079 name: light-harvesting complex, peripheral complex namespace: cellular_component def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030080 name: B875 antenna complex namespace: cellular_component def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] synonym: "LH1 complex" EXACT [] synonym: "light harvesting complex I" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030078 ! light-harvesting complex, core complex [Term] id: GO:0030081 name: B800-820 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] synonym: "LH3 complex" EXACT [] synonym: "light harvesting complex III" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030082 name: B800-850 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] synonym: "LH2 complex" EXACT [] synonym: "light harvesting complex II" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030083 name: PSI associated light-harvesting complex I, LHCIa subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030084 name: PSI associated light-harvesting complex I, LHCIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030085 name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex [Term] id: GO:0030086 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030087 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030088 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex namespace: cellular_component def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030089 name: phycobilisome namespace: cellular_component def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome] xref: Wikipedia:Phycobilisome is_a: GO:0030076 ! light-harvesting complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0030091 name: protein repair namespace: biological_process def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0030092 name: obsolete regulation of flagellum assembly namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "regulation of flagella assembly" RELATED [GOC:mah] synonym: "regulation of flagella biogenesis" RELATED [] synonym: "regulation of flagellum assembly" EXACT [] synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah] is_obsolete: true consider: GO:1902017 consider: GO:1902208 [Term] id: GO:0030093 name: chloroplast photosystem I namespace: cellular_component def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009522 ! photosystem I is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex intersection_of: GO:0009522 ! photosystem I intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0030094 name: plasma membrane-derived photosystem I namespace: cellular_component def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu] synonym: "plasma membrane photosystem I" EXACT [] is_a: GO:0009522 ! photosystem I is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0009522 ! photosystem I intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0030095 name: chloroplast photosystem II namespace: cellular_component def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009523 ! photosystem II is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex intersection_of: GO:0009523 ! photosystem II intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0030096 name: plasma membrane-derived thylakoid photosystem II namespace: cellular_component def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] synonym: "plasma membrane photosystem II" EXACT [] is_a: GO:0009523 ! photosystem II is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0009523 ! photosystem II intersection_of: part_of GO:0030075 ! bacterial thylakoid relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0030098 name: lymphocyte differentiation namespace: biological_process alt_id: GO:0046650 def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "lymphocyte cell differentiation" EXACT [] synonym: "lymphocyte development" RELATED [GOC:add] synonym: "lymphocytic blood cell differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006897 ! endocytosis relationship: regulates GO:0006897 ! endocytosis [Term] id: GO:0030101 name: natural killer cell activation namespace: biological_process def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] synonym: "NK cell activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030103 name: vasopressin secretion namespace: biological_process def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030104 name: water homeostasis namespace: biological_process alt_id: GO:0018987 def: "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] synonym: "osmoregulation" RELATED [] synonym: "regulation of osmotic pressure" EXACT [] xref: MIPS_funcat:36.20.35.09.01 xref: Wikipedia:Osmoregulation is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0030105 name: obsolete anaphylaxis namespace: biological_process def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732] comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism. synonym: "anaphylaxis" EXACT [] is_obsolete: true consider: GO:0006955 [Term] id: GO:0030106 name: obsolete MHC class I receptor activity namespace: molecular_function def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971] comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'. synonym: "class I major histocompatibility complex antigen" RELATED [] synonym: "major histocompatibility complex class I receptor" EXACT [] synonym: "MHC class I receptor activity" EXACT [] is_obsolete: true consider: GO:0032393 consider: GO:0042612 [Term] id: GO:0030107 name: HLA-A specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030108 name: HLA-A specific activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032397 ! activating MHC class I receptor activity [Term] id: GO:0030109 name: HLA-B specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030110 name: HLA-C specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030111 name: regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0008590 def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of frizzled signaling pathway" EXACT [] synonym: "regulation of frizzled signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signaling pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway" EXACT [] synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016055 ! Wnt signaling pathway relationship: regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030112 name: glycocalyx namespace: cellular_component def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208] subset: goslim_pir synonym: "cell capsule" EXACT [VZ:3896] xref: Wikipedia:Glycocalyx is_a: GO:0030312 ! external encapsulating structure relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0030114 name: slime layer namespace: cellular_component def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer] xref: MIPS_funcat:70.34.03 xref: Wikipedia:Slime_layer is_a: GO:0030112 ! glycocalyx [Term] id: GO:0030115 name: S-layer namespace: cellular_component def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] subset: goslim_pir xref: MIPS_funcat:70.34.05 xref: Wikipedia:S-layer is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0030116 name: glial cell-derived neurotrophic factor receptor binding namespace: molecular_function def: "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867] synonym: "glial cell line-derived neurotrophic factor receptor binding" RELATED [] synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030117 name: membrane coat namespace: cellular_component def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0048475 ! coated membrane [Term] id: GO:0030118 name: clathrin coat namespace: cellular_component alt_id: GO:0016190 def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] synonym: "clathrin cage" EXACT [] xref: NIF_Subcellular:sao879919129 xref: Wikipedia:Clathrin is_a: GO:0030117 ! membrane coat [Term] id: GO:0030119 name: AP-type membrane coat adaptor complex namespace: cellular_component def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] subset: goslim_pir synonym: "clathrin adaptor" RELATED [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030117 ! membrane coat [Term] id: GO:0030120 name: vesicle coat namespace: cellular_component def: "A membrane coat found on a coated vesicle." [GOC:mah] xref: NIF_Subcellular:sao1177708494 is_a: GO:0030117 ! membrane coat relationship: part_of GO:0030662 ! coated vesicle membrane [Term] id: GO:0030121 name: AP-1 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] synonym: "HA1" EXACT [] synonym: "HA1 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle [Term] id: GO:0030122 name: AP-2 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426] synonym: "HA2" EXACT [] synonym: "HA2 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle relationship: part_of GO:0030132 ! clathrin coat of coated pit [Term] id: GO:0030123 name: AP-3 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030124 name: AP-4 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030125 name: clathrin vesicle coat namespace: cellular_component def: "A clathrin coat found on a vesicle." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0030665 ! clathrin-coated vesicle membrane [Term] id: GO:0030126 name: COPI vesicle coat namespace: cellular_component alt_id: GO:0017167 def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] synonym: "coatomer" EXACT [] is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0030663 ! COPI-coated vesicle membrane [Term] id: GO:0030127 name: COPII vesicle coat namespace: cellular_component def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane [Term] id: GO:0030128 name: clathrin coat of endocytic vesicle namespace: cellular_component def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] synonym: "clathrin coat of endocytotic vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat intersection_of: GO:0030118 ! clathrin coat intersection_of: part_of GO:0030139 ! endocytic vesicle relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane [Term] id: GO:0030129 name: clathrin coat of synaptic vesicle namespace: cellular_component def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] is_a: GO:0030125 ! clathrin vesicle coat intersection_of: GO:0030118 ! clathrin coat intersection_of: part_of GO:0008021 ! synaptic vesicle relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0030130 name: clathrin coat of trans-Golgi network vesicle namespace: cellular_component def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] synonym: "clathrin coat of TGN vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane [Term] id: GO:0030131 name: clathrin adaptor complex namespace: cellular_component def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] is_a: GO:0030119 ! AP-type membrane coat adaptor complex relationship: part_of GO:0030118 ! clathrin coat [Term] id: GO:0030132 name: clathrin coat of coated pit namespace: cellular_component def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0030118 ! clathrin coat intersection_of: part_of GO:0005905 ! clathrin-coated pit relationship: part_of GO:0005905 ! clathrin-coated pit [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: MIPS_funcat:70.09 xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030134 name: COPII-coated ER to Golgi transport vesicle namespace: cellular_component alt_id: GO:0030138 alt_id: GO:0140045 def: "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII] synonym: "COPII vesicle" RELATED [] synonym: "COPII-associated ER to Golgi transport vesicle" EXACT [] synonym: "COPII-associated vesicle" EXACT [] synonym: "COPII-coated vesicle" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle" RELATED [] synonym: "endoplasmic reticulum-Golgi transport vesicle" RELATED [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle" RELATED [] synonym: "ER to Golgi transport vesicle" RELATED [] synonym: "ER-Golgi transport vesicle" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle created_by: pg creation_date: 2017-06-22T16:26:57Z [Term] id: GO:0030135 name: coated vesicle namespace: cellular_component alt_id: GO:0005909 def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] subset: goslim_drosophila xref: NIF_Subcellular:sao1985096626 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030136 name: clathrin-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] xref: NIF_Subcellular:sao148845161 is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030137 name: COPI-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] synonym: "coatomer" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030139 name: endocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] synonym: "endocytotic transport vesicle" EXACT [] synonym: "endocytotic vesicle" EXACT [] xref: NIF_Subcellular:sao1362520468 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030140 name: trans-Golgi network transport vesicle namespace: cellular_component def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] synonym: "TGN transport vesicle" EXACT [] synonym: "trans-Golgi network constitutive secretory pathway transport vesicle" EXACT [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030133 ! transport vesicle is_a: GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030142 name: COPI-coated Golgi to ER transport vesicle namespace: cellular_component def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157] synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi to ER constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-ER transport vesicle" EXACT [] synonym: "retrograde transport vesicle" EXACT [PMID:22160157] is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030143 name: COPI-coated inter-Golgi transport vesicle namespace: cellular_component alt_id: GO:0005807 def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle" EXACT [] xref: NIF_Subcellular:sao1382918459 is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030144 name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "GnTV activity" EXACT [EC:2.4.1.155] synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] xref: EC:2.4.1.155 xref: MetaCyc:2.4.1.155-RXN xref: Reactome:R-HSA-975916 "Addition of GlcNAc to position 5 by MGAT5" xref: RHEA:16921 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0030145 name: manganese ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] synonym: "manganese binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030146 name: obsolete diuresis namespace: biological_process alt_id: GO:0003076 def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732] comment: This term was made obsolete because its definition was inaccurate. synonym: "diuresis" EXACT [] synonym: "positive regulation of renal water excretion" EXACT [] synonym: "renal water excretion" BROAD [] xref: Wikipedia:Diuresis is_obsolete: true consider: GO:0035810 [Term] id: GO:0030147 name: obsolete natriuresis namespace: biological_process def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732] comment: This term was made obsolete because its definition was inaccurate. synonym: "natriuresis" EXACT [] xref: Wikipedia:Natriuresis is_obsolete: true consider: GO:0035815 [Term] id: GO:0030148 name: sphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid anabolism" EXACT [] synonym: "sphingolipid biosynthesis" EXACT [] synonym: "sphingolipid formation" EXACT [] synonym: "sphingolipid synthesis" EXACT [] xref: MetaCyc:PWY-5129 is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0030149 name: sphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid breakdown" EXACT [] synonym: "sphingolipid catabolism" EXACT [] synonym: "sphingolipid degradation" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030150 name: protein import into mitochondrial matrix namespace: biological_process def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonym: "mitochondrial matrix protein import" EXACT [] synonym: "mitochondrial translocation" BROAD [] synonym: "protein transport into mitochondrial matrix" EXACT [] is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0065002 ! intracellular protein transmembrane transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:1990542 ! mitochondrial transmembrane transport relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0030151 name: molybdenum ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] synonym: "molybdenum binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030152 name: bacteriocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] synonym: "bacteriocin anabolism" EXACT [] synonym: "bacteriocin biosynthesis" EXACT [] synonym: "bacteriocin formation" EXACT [] synonym: "bacteriocin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0046224 ! bacteriocin metabolic process [Term] id: GO:0030153 name: bacteriocin immunity namespace: biological_process def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: MIPS_funcat:40.02 xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007155 ! cell adhesion relationship: regulates GO:0007155 ! cell adhesion [Term] id: GO:0030156 name: benzodiazepine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] synonym: "benzodiazepine receptor ligand" NARROW [] synonym: "diazepam binding inhibitor activity" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030157 name: pancreatic juice secretion namespace: biological_process def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732] is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0030158 name: protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] synonym: "peptide O-xylosyltransferase activity" EXACT [] synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26] xref: EC:2.4.2.26 xref: MetaCyc:2.4.2.26-RXN xref: Reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein" is_a: GO:0035252 ! UDP-xylosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0030159 name: receptor signaling complex adaptor activity namespace: molecular_function def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] synonym: "receptor signaling complex scaffold activity" EXACT [] synonym: "receptor signaling complex scaffold protein activity" EXACT [] synonym: "receptor signalling complex scaffold activity" EXACT [] is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0030160 name: GKAP/Homer scaffold activity namespace: molecular_function def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216] synonym: "GKAP/Homer scaffold protein" NARROW [] synonym: "postsynaptic density scaffold protein" NARROW [] is_a: GO:0030159 ! receptor signaling complex adaptor activity [Term] id: GO:0030161 name: obsolete calpain inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] comment: This term was made obsolete because it represents a regulator of a non-existent molecular function. synonym: "calpain inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0010859 [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006508 ! proteolysis relationship: regulates GO:0006508 ! proteolysis [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process alt_id: GO:0044254 def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_pombe synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: MIPS_funcat:14.13 xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030164 name: protein denaturation namespace: biological_process def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359] xref: Wikipedia:Denaturation#Protein_denaturation is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0030165 name: PDZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] synonym: "DHR-domain binding" EXACT [] synonym: "GLGF-domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030166 name: proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan anabolism" EXACT [] synonym: "proteoglycan biosynthesis" EXACT [] synonym: "proteoglycan formation" EXACT [] synonym: "proteoglycan synthesis" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0030167 name: proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan breakdown" EXACT [] synonym: "proteoglycan catabolism" EXACT [] synonym: "proteoglycan degradation" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0030168 name: platelet activation namespace: biological_process def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0030169 name: low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] subset: goslim_chembl synonym: "LDL binding" EXACT [] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0030170 name: pyridoxal phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] subset: goslim_metagenomics xref: MIPS_funcat:16.21.17 is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0030171 name: voltage-gated proton channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:28774948] synonym: "voltage gated proton channel activity" EXACT [] synonym: "voltage-dependent proton channel activity" EXACT [] is_a: GO:0015252 ! proton channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0030172 name: troponin C binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030173 name: integral component of Golgi membrane namespace: cellular_component def: "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] synonym: "Golgi integral membrane protein" RELATED [] synonym: "integral to Golgi membrane" NARROW [] is_a: GO:0031228 ! intrinsic component of Golgi membrane is_a: GO:0031301 ! integral component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0000139 ! Golgi membrane [Term] id: GO:0030174 name: regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] synonym: "DNA replication licencing" EXACT [] synonym: "DNA replication licensing" EXACT [] synonym: "regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006270 ! DNA replication initiation relationship: regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0030175 name: filopodium namespace: cellular_component alt_id: GO:0030028 def: "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. subset: goslim_pir xref: NIF_Subcellular:sao1046371754 xref: Wikipedia:Filopodia is_a: GO:0098858 ! actin-based cell projection [Term] id: GO:0030176 name: integral component of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "ER integral membrane protein" EXACT [] synonym: "integral to endoplasmic reticulum membrane" NARROW [] synonym: "integral to ER membrane" EXACT [] is_a: GO:0031227 ! intrinsic component of endoplasmic reticulum membrane is_a: GO:0031301 ! integral component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0030177 name: positive regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045811 def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of frizzled signaling pathway" NARROW [] synonym: "activation of Wnt receptor signaling pathway" NARROW [] synonym: "positive regulation of frizzled signaling pathway" EXACT [] synonym: "positive regulation of frizzled signalling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "stimulation of frizzled signaling pathway" NARROW [] synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] synonym: "up regulation of frizzled signaling pathway" EXACT [] synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] synonym: "up-regulation of frizzled signaling pathway" EXACT [] synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "upregulation of frizzled signaling pathway" EXACT [] synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway relationship: positively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030178 name: negative regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045810 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled signaling pathway" EXACT [] synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] synonym: "down-regulation of frizzled signaling pathway" EXACT [] synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "downregulation of frizzled signaling pathway" EXACT [] synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] synonym: "inhibition of frizzled signaling pathway" NARROW [] synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] synonym: "negative regulation of frizzled signaling pathway" EXACT [] synonym: "negative regulation of frizzled signalling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016055 ! Wnt signaling pathway relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030180 name: obsolete solute:solute exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah] comment: This term was made obsolete because it represents a molecular function. synonym: "solute:solute exchange" EXACT [] is_obsolete: true consider: GO:0006810 consider: GO:0015297 [Term] id: GO:0030181 name: obsolete sodium:calcium exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732] comment: This term was made obsolete because it represents a function rather than a process. synonym: "sodium:calcium exchange" EXACT [] is_obsolete: true consider: GO:0005432 consider: GO:0006814 consider: GO:0006816 [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] xref: MIPS_funcat:43.03.13 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030183 name: B cell differentiation namespace: biological_process alt_id: GO:0042115 def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B cell development" RELATED [GOC:add] synonym: "B lymphocyte differentiation" EXACT [] synonym: "B-cell differentiation" EXACT [] synonym: "B-lymphocyte differentiation" EXACT [] xref: MIPS_funcat:43.03.09.03 is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation [Term] id: GO:0030184 name: nitric oxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0030185 ! nitric oxide transport [Term] id: GO:0030185 name: nitric oxide transport namespace: biological_process def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0030186 name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0030187 name: melatonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin anabolism" EXACT [] synonym: "melatonin biosynthesis" EXACT [] synonym: "melatonin formation" EXACT [] synonym: "melatonin synthesis" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0030188 name: obsolete chaperone regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone regulator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030189 name: obsolete chaperone activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone activator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030190 name: obsolete chaperone inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone inhibitor activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030191 name: obsolete Hsp70/Hsc70 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. synonym: "Hsp70/Hsc70 protein inhibitor activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030192 name: obsolete Hsp70/Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. synonym: "Hsp70/Hsc70 protein regulator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030193 name: regulation of blood coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050818 ! regulation of coagulation is_a: GO:0061041 ! regulation of wound healing is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007596 ! blood coagulation relationship: regulates GO:0007596 ! blood coagulation [Term] id: GO:0030194 name: positive regulation of blood coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "activation of blood coagulation" NARROW [] synonym: "stimulation of blood coagulation" NARROW [] synonym: "up regulation of blood coagulation" EXACT [] synonym: "up-regulation of blood coagulation" EXACT [] synonym: "upregulation of blood coagulation" EXACT [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050820 ! positive regulation of coagulation is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1900048 ! positive regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007596 ! blood coagulation relationship: positively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030195 name: negative regulation of blood coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "down regulation of blood coagulation" EXACT [] synonym: "down-regulation of blood coagulation" EXACT [] synonym: "downregulation of blood coagulation" EXACT [] synonym: "inhibition of blood coagulation" NARROW [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050819 ! negative regulation of coagulation is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1900047 ! negative regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007596 ! blood coagulation relationship: negatively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030196 name: cyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21720] synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66] xref: EC:4.2.1.66 xref: KEGG_REACTION:R01408 xref: MetaCyc:CYANIDE-HYDRATASE-RXN xref: RHEA:21720 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030197 name: extracellular matrix constituent, lubricant activity namespace: molecular_function def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] comment: Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.27.01 is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [] synonym: "fibrillar collagen organization" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0030200 name: heparan sulfate proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate proteoglycan breakdown" EXACT [] synonym: "heparan sulfate proteoglycan catabolism" EXACT [] synonym: "heparan sulfate proteoglycan degradation" EXACT [] synonym: "heparan sulphate proteoglycan catabolic process" EXACT [] synonym: "heparan sulphate proteoglycan catabolism" EXACT [] synonym: "heparin proteoglycan catabolic process" RELATED [] is_a: GO:0030167 ! proteoglycan catabolic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process [Term] id: GO:0030201 name: heparan sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate proteoglycan metabolism" EXACT [] synonym: "heparan sulphate proteoglycan metabolic process" EXACT [] synonym: "heparan sulphate proteoglycan metabolism" EXACT [] synonym: "heparin proteoglycan metabolic process" RELATED [] is_a: GO:0006029 ! proteoglycan metabolic process [Term] id: GO:0030202 name: heparin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate metabolic process" RELATED [] synonym: "heparin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981] synonym: "glycosaminoglycan metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0030204 name: chondroitin sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate metabolism" EXACT [] synonym: "chondroitin sulphate metabolic process" EXACT [] synonym: "chondroitin sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0030205 name: dermatan sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B metabolic process" EXACT [] synonym: "chondroitin sulfate B metabolism" EXACT [] synonym: "dermatan sulfate metabolism" EXACT [] synonym: "dermatan sulphate metabolic process" EXACT [] synonym: "dermatan sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process [Term] id: GO:0030206 name: chondroitin sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate anabolism" EXACT [] synonym: "chondroitin sulfate biosynthesis" EXACT [] synonym: "chondroitin sulfate formation" EXACT [] synonym: "chondroitin sulfate synthesis" EXACT [] synonym: "chondroitin sulphate biosynthesis" EXACT [] synonym: "chondroitin sulphate biosynthetic process" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process [Term] id: GO:0030207 name: chondroitin sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate breakdown" EXACT [] synonym: "chondroitin sulfate catabolism" EXACT [] synonym: "chondroitin sulfate degradation" EXACT [] synonym: "chondroitin sulphate catabolic process" EXACT [] synonym: "chondroitin sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030208 name: dermatan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B biosynthesis" EXACT [] synonym: "chondroitin sulfate B biosynthetic process" EXACT [] synonym: "dermatan sulfate anabolism" EXACT [] synonym: "dermatan sulfate biosynthesis" EXACT [] synonym: "dermatan sulfate formation" EXACT [] synonym: "dermatan sulfate synthesis" EXACT [] synonym: "dermatan sulphate biosynthesis" EXACT [] synonym: "dermatan sulphate biosynthetic process" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process [Term] id: GO:0030209 name: dermatan sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B catabolic process" EXACT [] synonym: "chondroitin sulfate B catabolism" EXACT [] synonym: "dermatan sulfate breakdown" EXACT [] synonym: "dermatan sulfate catabolism" EXACT [] synonym: "dermatan sulfate degradation" EXACT [] synonym: "dermatan sulphate catabolic process" EXACT [] synonym: "dermatan sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0030210 name: heparin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate biosynthetic process" RELATED [] synonym: "heparin anabolism" EXACT [] synonym: "heparin biosynthesis" EXACT [] synonym: "heparin formation" EXACT [] synonym: "heparin synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0030211 name: heparin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate catabolic process" RELATED [] synonym: "heparin breakdown" EXACT [] synonym: "heparin catabolism" EXACT [] synonym: "heparin degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0030215 name: semaphorin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990] synonym: "plexin binding" NARROW [] synonym: "plexin ligand" NARROW [] synonym: "semaphorin receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030216 name: keratinocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] synonym: "keratinocyte cell differentiation" EXACT [] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0043588 ! skin development [Term] id: GO:0030217 name: T cell differentiation namespace: biological_process alt_id: GO:0042112 alt_id: GO:0046652 def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development" RELATED [GOC:add] synonym: "T lymphocyte differentiation" EXACT [] synonym: "T-cell differentiation" EXACT [] synonym: "T-lymphocyte differentiation" EXACT [] xref: MIPS_funcat:43.03.09.01 is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: MIPS_funcat:43.03.07 xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030220 name: platelet formation namespace: biological_process def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators] is_a: GO:0030099 ! myeloid cell differentiation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0036344 ! platelet morphogenesis [Term] id: GO:0030221 name: basophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah] synonym: "basophil cell differentiation" EXACT [] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030222 name: eosinophil differentiation namespace: biological_process alt_id: GO:0035856 def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah] synonym: "eosinophil cell development" RELATED [GOC:bf] synonym: "eosinophil cell differentiation" EXACT [] synonym: "eosinophil development" RELATED [] is_a: GO:0030851 ! granulocyte differentiation is_a: GO:0048468 ! cell development [Term] id: GO:0030223 name: neutrophil differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] synonym: "neutrophil cell differentiation" EXACT [] synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf] synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030224 name: monocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] synonym: "monocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation [Term] id: GO:0030225 name: macrophage differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] synonym: "macrophage cell differentiation" EXACT [] xref: MIPS_funcat:43.03.09.05 is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030226 name: apolipoprotein receptor activity namespace: molecular_function def: "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] is_a: GO:0038024 ! cargo receptor activity relationship: has_part GO:0034185 ! apolipoprotein binding [Term] id: GO:0030227 name: obsolete apolipoprotein E receptor activity namespace: molecular_function def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). synonym: "ApoE receptor" EXACT [] synonym: "apolipoprotein E receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0030229 [Term] id: GO:0030228 name: lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279] comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'. synonym: "lipoprotein receptor activity" EXACT [GOC:dph] synonym: "plasma lipoprotein particle receptor activity" NARROW [GOC:BHF] is_a: GO:0038024 ! cargo receptor activity relationship: has_part GO:0071813 ! lipoprotein particle binding [Term] id: GO:0030229 name: very-low-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732] synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl] synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph] synonym: "VLDL receptor" EXACT [] xref: Wikipedia:VLDL_receptor is_a: GO:0030228 ! lipoprotein particle receptor activity relationship: has_part GO:0034189 ! very-low-density lipoprotein particle binding [Term] id: GO:0030232 name: insulin control element activator complex namespace: cellular_component def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] synonym: "ICE activator complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0030233 name: deoxynucleotide transmembrane transporter activity namespace: molecular_function def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] is_a: GO:0015215 ! nucleotide transmembrane transporter activity relationship: part_of GO:0030302 ! deoxynucleotide transport [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function alt_id: GO:0010576 def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] synonym: "metalloenzyme regulator activity" NARROW [] xref: MIPS_funcat:18.02.01 is_a: GO:0098772 ! molecular function regulator relationship: part_of GO:0050790 ! regulation of catalytic activity [Term] id: GO:0030235 name: nitric-oxide synthase regulator activity namespace: molecular_function def: "Modulates the activity of nitric oxide synthase." [GOC:mah] comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. synonym: "nitric oxide synthase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0050998 ! nitric-oxide synthase binding relationship: regulates GO:0004517 ! nitric-oxide synthase activity [Term] id: GO:0030237 name: female sex determination namespace: biological_process def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0030238 name: male sex determination namespace: biological_process def: "The specification of male sex of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0070925 ! organelle assembly is_a: GO:0097435 ! supramolecular fiber organization relationship: part_of GO:0055002 ! striated muscle cell development [Term] id: GO:0030240 name: skeletal muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030241 name: skeletal muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0071688 ! striated muscle myosin thick filament assembly relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030242 name: autophagy of peroxisome namespace: biological_process def: "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] synonym: "peroxisome degradation" BROAD [] synonym: "pexophagy" RELATED [] is_a: GO:0006914 ! autophagy relationship: has_part GO:1905683 ! peroxisome disassembly [Term] id: GO:0030243 name: cellulose metabolic process namespace: biological_process alt_id: GO:0016177 def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0030244 name: cellulose biosynthetic process namespace: biological_process alt_id: GO:0016178 def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose anabolism" EXACT [] synonym: "cellulose biosynthesis" EXACT [] synonym: "cellulose formation" EXACT [] synonym: "cellulose synthesis" EXACT [] xref: MetaCyc:PWY-1001 is_a: GO:0030243 ! cellulose metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0030245 name: cellulose catabolic process namespace: biological_process alt_id: GO:0016179 def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose breakdown" EXACT [] synonym: "cellulose catabolism" EXACT [] synonym: "cellulose degradation" EXACT [] is_a: GO:0030243 ! cellulose metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function alt_id: GO:0002506 def: "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah] synonym: "polysaccharide assembly with MHC class II protein complex" NARROW [] xref: MIPS_funcat:16.05 is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0030248 name: cellulose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellulose." [GOC:mah] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0030249 name: guanylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of guanylate cyclase." [GOC:mah] is_a: GO:0010851 ! cyclase regulator activity relationship: part_of GO:0031282 ! regulation of guanylate cyclase activity relationship: regulates GO:0004383 ! guanylate cyclase activity [Term] id: GO:0030250 name: guanylate cyclase activator activity namespace: molecular_function def: "Binds to and increases the activity of guanylate cyclase." [GOC:mah] synonym: "guanylin" NARROW [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0010853 ! cyclase activator activity is_a: GO:0030249 ! guanylate cyclase regulator activity relationship: part_of GO:0031284 ! positive regulation of guanylate cyclase activity relationship: positively_regulates GO:0004383 ! guanylate cyclase activity [Term] id: GO:0030251 name: guanylate cyclase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] is_a: GO:0010852 ! cyclase inhibitor activity is_a: GO:0030249 ! guanylate cyclase regulator activity relationship: negatively_regulates GO:0004383 ! guanylate cyclase activity relationship: part_of GO:0031283 ! negative regulation of guanylate cyclase activity [Term] id: GO:0030252 name: growth hormone secretion namespace: biological_process def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] synonym: "somatotropin secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030253 name: protein secretion by the type I secretion system namespace: biological_process def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. synonym: "protein secretion by the TOSS" EXACT [] synonym: "protein secretion by the type I protein secretion system" EXACT [] synonym: "type I protein secretion system" EXACT [] xref: MIPS_funcat:20.09.16.01 is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030254 name: protein secretion by the type III secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. synonym: "protein secretion by the T3S" EXACT [] synonym: "protein secretion by the T3SS" EXACT [] synonym: "protein secretion by the TTSS" EXACT [] synonym: "protein secretion by the type III protein secretion system" EXACT [] synonym: "type III protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030255 name: protein secretion by the type IV secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. synonym: "protein secretion by the T4SS" EXACT [] synonym: "protein secretion by the type IV protein secretion system" EXACT [] synonym: "type IV protein secretion system" NARROW [] xref: MIPS_funcat:20.09.16.04 xref: MIPS_funcat:20.09.16.05 is_a: GO:0009306 ! protein secretion is_a: GO:0044097 ! secretion by the type IV secretion system is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030256 name: type I protein secretion system complex namespace: cellular_component def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] synonym: "ABC translocator complex" BROAD [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0030257 name: type III protein secretion system complex namespace: cellular_component def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] synonym: "T3SS complex" EXACT [] synonym: "TTSS complex" EXACT [] xref: MIPS_funcat:20.09.16.03 is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0030258 name: lipid modification namespace: biological_process def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0030259 name: lipid glycosylation namespace: biological_process def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] is_a: GO:0030258 ! lipid modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0030260 name: entry into host cell namespace: biological_process alt_id: GO:0044411 alt_id: GO:0051806 alt_id: GO:0051830 def: "The invasion by a symbiont of a cell of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm] synonym: "entry into cell of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED [] synonym: "entry into host through host barriers" RELATED [] synonym: "host cell invasion" EXACT [] synonym: "other organism cell invasion" RELATED [] is_a: GO:0044409 ! entry into host [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] xref: MIPS_funcat:10.03.04.03 is_a: GO:0006323 ! DNA packaging [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: part_of GO:0030262 ! apoptotic nuclear changes relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030265 name: phospholipase C-activating rhodopsin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931] synonym: "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] synonym: "PLC-activating rhodopsin mediated signaling pathway" EXACT [GOC:bf] synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G-protein signaling, coupled to IP3 second messenger" EXACT [GOC:signaling] synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0030266 name: quinate 3-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+." [EC:1.1.1.24] synonym: "quinate:NAD 3-oxidoreductase activity" EXACT [] synonym: "quinate:NAD 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinate:NAD(+) 3-oxidoreductase activity" EXACT [] synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24] xref: EC:1.1.1.24 xref: EC:1.1.1.282 xref: KEGG_REACTION:R01872 xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN xref: RHEA:22364 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030267 name: glyoxylate reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79] synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79] synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79] xref: EC:1.1.1.79 xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN xref: Reactome:R-HSA-389826 "glyoxylate + NADPH + H+ => glycolate + NADP+" xref: RHEA:10992 xref: Wikipedia:Glyoxylate_reductase_(NADP+) is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030268 name: methylenetetrahydromethanopterin dehydrogenase activity namespace: molecular_function alt_id: GO:0018536 def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.1, RHEA:16721] synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.98.1] synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.98.1] synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.98.1] xref: EC:1.5.98.1 xref: KEGG_REACTION:R04456 xref: MetaCyc:1.5.99.9-RXN xref: RHEA:16721 xref: UM-BBD_reactionID:r0348 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0030269 name: tetrahydromethanopterin S-methyltransferase activity namespace: molecular_function alt_id: GO:0018709 def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:17588] synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86] xref: EC:2.1.1.86 xref: KEGG_REACTION:R04347 xref: MetaCyc:2.1.1.86-RXN xref: RHEA:17588 xref: UM-BBD_reactionID:r0355 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity [Term] id: GO:0030270 name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity namespace: molecular_function alt_id: GO:0018714 def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18061] synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "FTR" RELATED [EC:2.3.1.101] synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101] xref: EC:2.3.1.101 xref: KEGG_REACTION:R03390 xref: MetaCyc:2.3.1.101-RXN xref: RHEA:18061 xref: UM-BBD_reactionID:r0346 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0030271 name: obsolete chymase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39] comment: This term was made obsolete because it represents a gene product. synonym: "chymase activity" EXACT [] synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39] synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39] synonym: "SK protease activity" EXACT [EC:3.4.21.39] synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] xref: EC:3.4.21.39 xref: MetaCyc:3.4.21.39-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030272 name: 5-formyltetrahydrofolate cyclo-ligase activity namespace: molecular_function alt_id: GO:0019006 def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10488] synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2] xref: EC:6.3.3.2 xref: KEGG_REACTION:R02301 xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN xref: Reactome:R-HSA-6801342 "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG" xref: RHEA:10488 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0030273 name: melanin-concentrating hormone receptor activity namespace: molecular_function def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] synonym: "MCH receptor" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0030274 name: LIM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030275 name: LRR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030276 name: clathrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0030277 name: maintenance of gastrointestinal epithelium namespace: biological_process def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah] is_a: GO:0010669 ! epithelial structure maintenance is_a: GO:0022600 ! digestive system process [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001503 ! ossification relationship: regulates GO:0001503 ! ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001503 ! ossification relationship: negatively_regulates GO:0001503 ! ossification [Term] id: GO:0030280 name: structural constituent of skin epidermis namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] synonym: "structural constituent of epidermis" BROAD [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030281 name: structural constituent of cutaneous appendage namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030282 name: bone mineralization namespace: biological_process def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354] synonym: "bone calcification" NARROW [] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0001503 ! ossification [Term] id: GO:0030283 name: testosterone dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] xref: EC:1.1.1.51 xref: MetaCyc:1.1.1.51-RXN xref: Reactome:R-HSA-193064 "Reduction of androstenedione to testosterone" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030284 name: estrogen receptor activity namespace: molecular_function def: "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392] comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0030285 name: integral component of synaptic vesicle membrane namespace: cellular_component def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_synapse synonym: "integral to synaptic vesicle membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0030286 name: dynein complex namespace: cellular_component def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] is_a: GO:0005875 ! microtubule associated complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0030287 name: cell wall-bounded periplasmic space namespace: cellular_component def: "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu] synonym: "cell wall bounded periplasmic space" EXACT [] synonym: "cell wall-enclosed periplasmic space" EXACT [] synonym: "inner wall zone" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] synonym: "IWZ" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] is_a: GO:0042597 ! periplasmic space [Term] id: GO:0030288 name: outer membrane-bounded periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu] synonym: "outer membrane bounded periplasmic space" EXACT [] synonym: "outer membrane-enclosed periplasmic space" EXACT [] xref: Wikipedia:Periplasmic_space is_a: GO:0042597 ! periplasmic space relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0030289 name: protein phosphatase 4 complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142] is_a: GO:0008287 ! protein serine/threonine phosphatase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030290 name: sphingolipid activator protein activity namespace: molecular_function def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732] synonym: "saposin" NARROW [] xref: Reactome:R-HSA-1605717 "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage" is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0030291 name: protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0071901 ! negative regulation of protein serine/threonine kinase activity [Term] id: GO:0030292 name: protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity relationship: part_of GO:0061099 ! negative regulation of protein tyrosine kinase activity [Term] id: GO:0030293 name: transmembrane receptor protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity is_a: GO:0030547 ! receptor inhibitor activity relationship: negatively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0030294 name: receptor signaling protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity [Term] id: GO:0030295 name: protein kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019209 ! kinase activator activity is_a: GO:0019887 ! protein kinase regulator activity relationship: part_of GO:0032147 ! activation of protein kinase activity [Term] id: GO:0030296 name: protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732] is_a: GO:0030295 ! protein kinase activator activity relationship: part_of GO:0061098 ! positive regulation of protein tyrosine kinase activity [Term] id: GO:0030297 name: transmembrane receptor protein tyrosine kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030296 ! protein tyrosine kinase activator activity is_a: GO:0030546 ! signaling receptor activator activity relationship: part_of GO:0007171 ! activation of transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0030298 name: receptor signaling protein tyrosine kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] is_a: GO:0030296 ! protein tyrosine kinase activator activity relationship: positively_regulates GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0030299 name: intestinal cholesterol absorption namespace: biological_process def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0098856 ! intestinal lipid absorption relationship: part_of GO:0044241 ! lipid digestion [Term] id: GO:0030300 name: regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:1904729 ! regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030299 ! intestinal cholesterol absorption relationship: regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0030301 name: cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732] is_a: GO:0015918 ! sterol transport [Term] id: GO:0030302 name: deoxynucleotide transport namespace: biological_process def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732] is_a: GO:0006862 ! nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0030303 name: obsolete stromelysin 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22] synonym: "MMP-10" EXACT [] synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] synonym: "stromelysin 2 activity" EXACT [] synonym: "transin 2 activity" EXACT [EC:3.4.24.22] xref: EC:3.4.24.22 xref: MetaCyc:3.4.24.22-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030304 name: obsolete trypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "trypsin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030305 name: heparanase activity namespace: molecular_function def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] synonym: "heparinase activity" RELATED [] xref: Reactome:R-HSA-1667005 "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)" xref: Reactome:R-HSA-1678694 "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030306 name: ADP-ribosylation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732] synonym: "ARF binding" EXACT [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016049 ! cell growth relationship: positively_regulates GO:0016049 ! cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016049 ! cell growth relationship: negatively_regulates GO:0016049 ! cell growth [Term] id: GO:0030309 name: poly-N-acetyllactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0030310 name: poly-N-acetyllactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine breakdown" EXACT [] synonym: "poly-N-acetyllactosamine catabolism" EXACT [] synonym: "poly-N-acetyllactosamine degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030311 name: poly-N-acetyllactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine anabolism" EXACT [] synonym: "poly-N-acetyllactosamine biosynthesis" EXACT [] synonym: "poly-N-acetyllactosamine formation" EXACT [] synonym: "poly-N-acetyllactosamine synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0030313 name: cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] subset: goslim_pir xref: MIPS_funcat:70.34 xref: Wikipedia:Cell_envelope is_a: GO:0031975 ! envelope relationship: has_part GO:0005886 ! plasma membrane [Term] id: GO:0030314 name: junctional membrane complex namespace: cellular_component def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] synonym: "triad junction" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0030315 name: T-tubule namespace: cellular_component def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] synonym: "transverse tubule" EXACT [] synonym: "triad" RELATED [] xref: Wikipedia:T-tubule is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0042383 ! sarcolemma [Term] id: GO:0030316 name: osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] synonym: "osteoclast cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030317 name: flagellated sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a flagellated sperm cell." [GOC:cilia, GOC:jl, GOC:krc] synonym: "flagellated sperm movement" EXACT [] synonym: "sperm motility" BROAD [] synonym: "sperm movement" BROAD [] xref: Wikipedia:Sperm_motility is_a: GO:0060285 ! cilium-dependent cell motility is_a: GO:0097722 ! sperm motility [Term] id: GO:0030318 name: melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] synonym: "melanocyte cell differentiation" EXACT [] synonym: "melanophore differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0030319 name: obsolete cellular di-, tri-valent inorganic anion homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] comment: This term was made obsolete because it has been split. synonym: "cellular di-, tri-valent inorganic anion homeostasis" EXACT [] is_obsolete: true consider: GO:0072501 consider: GO:0072502 [Term] id: GO:0030320 name: cellular monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0030321 name: transepithelial chloride transport namespace: biological_process def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah] is_a: GO:0006821 ! chloride transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0030322 name: stabilization of membrane potential namespace: biological_process def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] xref: MIPS_funcat:47.03.09.01 is_a: GO:0048513 ! animal organ development relationship: part_of GO:0030323 ! respiratory tube development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0030325 name: adrenal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] synonym: "interrenal gland" RELATED [] xref: MIPS_funcat:47.03.21.03.01 is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030326 name: embryonic limb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035113 ! embryonic appendage morphogenesis [Term] id: GO:0030327 name: prenylated protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah] synonym: "prenylated protein breakdown" EXACT [] synonym: "prenylated protein catabolism" EXACT [] synonym: "prenylated protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0030328 name: prenylcysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] synonym: "prenylcysteine breakdown" EXACT [] synonym: "prenylcysteine catabolism" EXACT [] synonym: "prenylcysteine degradation" EXACT [] is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0030329 ! prenylcysteine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0030329 name: prenylcysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894] synonym: "prenylcysteine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0030330 name: DNA damage response, signal transduction by p53 class mediator namespace: biological_process alt_id: GO:0006976 def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] synonym: "DNA damage response, activation of p53" RELATED [] synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk] synonym: "p53-mediated DNA damage response" BROAD [] synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk] is_a: GO:0042770 ! signal transduction in response to DNA damage is_a: GO:0072331 ! signal transduction by p53 class mediator [Term] id: GO:0030331 name: estrogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an estrogen receptor." [GOC:ai] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0030332 name: cyclin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] is_a: GO:0005515 ! protein binding [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016477 ! cell migration relationship: regulates GO:0016477 ! cell migration [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016477 ! cell migration relationship: positively_regulates GO:0016477 ! cell migration [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016477 ! cell migration relationship: negatively_regulates GO:0016477 ! cell migration [Term] id: GO:0030337 name: DNA polymerase processivity factor activity namespace: molecular_function def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839] synonym: "processivity clamp" EXACT [] synonym: "sliding clamp" NARROW [GOC:jh2, PMID:23012374] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0006259 ! DNA metabolic process [Term] id: GO:0030338 name: CMP-N-acetylneuraminate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] comment: Note that this was EC:1.14.13.45. synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2] synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] xref: EC:1.14.18.2 xref: MetaCyc:1.14.13.45-RXN is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0030339 name: fatty-acyl-ethyl-ester synthase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67] synonym: "FAEES activity" EXACT [EC:3.1.1.67] synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] xref: EC:3.1.1.67 xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030340 name: hyaluronate lyase activity namespace: molecular_function def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1] synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] synonym: "mucinase activity" EXACT [EC:4.2.2.1] synonym: "spreading factor activity" RELATED [EC:4.2.2.1] xref: EC:4.2.2.1 xref: MetaCyc:HYALURONATE-LYASE-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030341 name: chondroitin AC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] synonym: "ChnAC" RELATED [] synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5] synonym: "chondroitin lyase activity" EXACT [] synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5] synonym: "chondroitinase AC" RELATED [] synonym: "chondroitinase activity" BROAD [] xref: EC:4.2.2.5 xref: MetaCyc:4.2.2.5-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030342 name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296] synonym: "calcitriol 24-hydroxylase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-209765 "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it" xref: Reactome:R-HSA-211950 "CYP24A1 24-hydroxylates CTL" xref: Reactome:R-HSA-5602004 "Defective CYP24A1 does not 24-hydroxylate CALTOL" is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0030343 name: vitamin D3 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309, MetaCyc:RXN-9829] synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] xref: MetaCyc:RXN-9829 xref: Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D" xref: Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D" is_a: GO:0070643 ! vitamin D 25-hydroxylase activity relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol [Term] id: GO:0030345 name: structural constituent of tooth enamel namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance [Term] id: GO:0030346 name: protein phosphatase 2B binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [GOC:jl] synonym: "calcineurin binding" EXACT [] synonym: "protein phosphatase 3 binding" RELATED [GOC:dph, GOC:rl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0030348 name: syntaxin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-3." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0030350 name: iron-responsive element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] synonym: "IRE binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0030351 name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen" is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity [Term] id: GO:0030352 name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity [Term] id: GO:0030353 name: fibroblast growth factor receptor antagonist activity namespace: molecular_function def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] synonym: "FGF receptor antagonist activity" EXACT [] synonym: "FGFR antagonist activity" EXACT [] is_a: GO:0005104 ! fibroblast growth factor receptor binding is_a: GO:0048019 ! receptor antagonist activity relationship: part_of GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway [Term] id: GO:0030354 name: melanin-concentrating hormone activity namespace: molecular_function def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536] is_a: GO:0005179 ! hormone activity [Term] id: GO:0030355 name: obsolete small nucleolar ribonucleoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_obsolete: true replaced_by: GO:0005732 [Term] id: GO:0030356 name: obsolete small cytoplasmic ribonucleoprotein namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0030363 name: obsolete pre-mRNA cleavage factor activity namespace: molecular_function def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856] comment: This term was made obsolete because it describes a biological process. synonym: "pre-mRNA cleavage factor activity" EXACT [] is_obsolete: true consider: GO:0006379 [Term] id: GO:0030364 name: obsolete cleavage and polyadenylylation specificity factor activity namespace: molecular_function def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "cleavage and polyadenylation specificity factor activity" EXACT [] synonym: "cleavage and polyadenylylation specificity factor activity" EXACT [] synonym: "cleavage/polyadenylation specificity factor activity" EXACT [] synonym: "CPSF" EXACT [] is_obsolete: true replaced_by: GO:0005847 consider: GO:0006378 consider: GO:0006379 [Term] id: GO:0030365 name: obsolete cleavage stimulation factor activity namespace: molecular_function def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "cleavage stimulation factor activity" EXACT [] synonym: "CstF" EXACT [] is_obsolete: true replaced_by: GO:0005848 consider: GO:0006379 [Term] id: GO:0030366 name: molybdopterin synthase activity namespace: molecular_function def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] xref: EC:2.8.1.12 xref: Reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0030367 name: interleukin-17 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17 receptor." [GOC:ai] synonym: "IL-17" NARROW [] synonym: "interleukin-17 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030368 name: interleukin-17 receptor activity namespace: molecular_function def: "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling] synonym: "IL-17 receptor activity" EXACT [GOC:mah] synonym: "IL-17R" EXACT [] xref: Wikipedia:Interleukin-17_receptor is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0019975 ! interleukin-17 binding [Term] id: GO:0030369 name: ICAM-3 receptor activity namespace: molecular_function def: "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0030370 name: intercellular adhesion molecule-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] synonym: "ICAM-3 receptor binding" EXACT [] synonym: "ICAM-3 receptor ligand" NARROW [] synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030371 name: translation repressor activity namespace: molecular_function def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] is_a: GO:0045182 ! translation regulator activity relationship: part_of GO:0017148 ! negative regulation of translation [Term] id: GO:0030372 name: high molecular weight B cell growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai] synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030373 name: high molecular weight B cell growth factor receptor activity namespace: molecular_function def: "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271] synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] synonym: "HMW-BCGF receptor" EXACT [PMID:2681271] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0030374 name: nuclear receptor transcription coactivator activity namespace: molecular_function alt_id: GO:0038049 def: "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] comment: GO:0030374 is intended for annotation of nuclear receptors that regulate transcription by binding to transcription factors or transcription factor complexes. When the nuclear receptor functions by binding directly to DNA response elements, consider instead annotating to 'nuclear receptor activity ; GO:0004879'. synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT [] synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT [] is_a: GO:0003713 ! transcription coactivator activity created_by: rfoulger creation_date: 2011-11-29T01:53:30Z [Term] id: GO:0030375 name: thyroid hormone receptor coactivator activity namespace: molecular_function alt_id: GO:0010861 def: "The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] synonym: "thyroid hormone receptor activator activity" NARROW [] synonym: "thyroid hormone receptor co-activator activity" EXACT [] is_a: GO:0030374 ! nuclear receptor transcription coactivator activity [Term] id: GO:0030377 name: urokinase plasminogen activator receptor activity namespace: molecular_function def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079] synonym: "U-plasminogen activator receptor activity" EXACT [GOC:bf] synonym: "uPAR" EXACT [] synonym: "urokinase plasminogen activator receptor" EXACT [] xref: Wikipedia:Urokinase_receptor is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0038195 ! urokinase plasminogen activator signaling pathway [Term] id: GO:0030378 name: serine racemase activity namespace: molecular_function def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] xref: EC:5.1.1.18 xref: MetaCyc:5.1.1.18-RXN xref: Reactome:R-HSA-9014766 "SRR dimer:PXLP isomerises L-Ser to D-Ser" is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0030379 name: neurotensin receptor activity, non-G protein-coupled namespace: molecular_function def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851] synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] synonym: "neurotensin receptor activity, non-G-protein coupled" EXACT [] synonym: "non G protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0030380 name: interleukin-17E receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17E receptor." [GOC:ai] synonym: "IL-17E" NARROW [] synonym: "interleukin-17E receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030381 name: chorion-containing eggshell pattern formation namespace: biological_process def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0030382 name: sperm mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] synonym: "sperm mitochondria organisation" EXACT [] synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah] synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0030383 name: obsolete host-pathogen interaction namespace: biological_process def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl] comment: This term was made obsolete because more appropriate terms were created. synonym: "host-pathogen interaction" EXACT [] is_obsolete: true consider: GO:0044403 [Term] id: GO:0030385 name: ferredoxin:thioredoxin reductase activity namespace: molecular_function def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790] is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0030386 name: ferredoxin:thioredoxin reductase complex namespace: cellular_component def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'. is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0030387 name: fructosamine-3-kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-phosphate." [PMID:11016445] is_a: GO:0016301 ! kinase activity [Term] id: GO:0030388 name: fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732] synonym: "fructose 1,6-bisphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0030389 name: fructosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0030391 name: fructosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine anabolism" EXACT [] synonym: "fructosamine biosynthesis" EXACT [] synonym: "fructosamine formation" EXACT [] synonym: "fructosamine synthesis" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0030392 name: fructosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine breakdown" EXACT [] synonym: "fructosamine catabolism" EXACT [] synonym: "fructosamine degradation" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0030393 name: fructoselysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai] synonym: "fructoselysine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030394 name: fructoseglycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai] synonym: "fructoseglycine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030395 name: lactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:0192800981] is_a: GO:0048030 ! disaccharide binding [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization [Term] id: GO:0030398 name: peroxisomal membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760] synonym: "peroxisomal membrane breakdown" EXACT [] synonym: "peroxisomal membrane catabolism" EXACT [] synonym: "peroxisomal membrane degradation" EXACT [] is_a: GO:0030397 ! membrane disassembly is_a: GO:1903008 ! organelle disassembly relationship: part_of GO:0030242 ! autophagy of peroxisome [Term] id: GO:0030399 name: autophagosome membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah] synonym: "autophagic membrane breakdown" EXACT [] synonym: "autophagic membrane catabolism" NARROW [GOC:autophagy] synonym: "autophagic membrane degradation" NARROW [GOC:autophagy] synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy] is_a: GO:0030397 ! membrane disassembly is_a: GO:1905037 ! autophagosome organization [Term] id: GO:0030400 name: obsolete protease substrate recruitment factor activity namespace: molecular_function def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370] comment: This term was made obsolete because it represents a gene product. synonym: "protease substrate recruitment factor activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0030401 name: obsolete transcription antiterminator activity namespace: molecular_function def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription antiterminator activity" EXACT [] synonym: "transcriptional antiterminator activity" EXACT [] is_obsolete: true consider: GO:0001072 consider: GO:0001073 consider: GO:0006353 [Term] id: GO:0030402 name: obsolete matrilysin-2 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrilysin-2 activity" EXACT [] synonym: "matrix metalloproteinase 26" EXACT [] synonym: "MMP-26" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030403 name: obsolete collagenase 4 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase 4 activity" EXACT [] synonym: "matrix metalloproteinase 18" EXACT [] synonym: "MMP-18" NARROW [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030404 name: obsolete collagenase 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase 3 activity" EXACT [] synonym: "matrix metalloproteinase 13" EXACT [] synonym: "MMP-13" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030405 name: obsolete matrix metalloproteinase 19 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 19 activity" EXACT [] synonym: "MMP-19" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030406 name: obsolete matrix metalloproteinase 25 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 25 activity" EXACT [] synonym: "MMP-25" EXACT [] synonym: "MT6-MMP" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030407 name: formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah] synonym: "formiminotransferase activity" EXACT [] is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0030408 name: glycine formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4, RHEA:24288] synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4] synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "glycine formiminotransferase activity" EXACT [] xref: EC:2.1.2.4 xref: KEGG_REACTION:R02729 xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN xref: RHEA:24288 is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030409 name: glutamate formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5] synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5] synonym: "glutamate formiminotransferase activity" EXACT [] synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] xref: EC:2.1.2.5 xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030410 name: nicotianamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16481] synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43] xref: EC:2.5.1.43 xref: KEGG_REACTION:R00075 xref: MetaCyc:2.5.1.43-RXN xref: RHEA:16481 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0030411 name: scytalone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24396] synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94] synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94] xref: EC:4.2.1.94 xref: KEGG_REACTION:R02907 xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN xref: RHEA:24396 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030412 name: formimidoyltetrahydrofolate cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22736] comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4] synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4] synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4] xref: EC:4.3.1.4 xref: KEGG_REACTION:R02302 xref: MetaCyc:4.3.1.4-RXN xref: Reactome:R-HSA-70920 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate" xref: RHEA:22736 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0030413 name: competence pheromone activity namespace: molecular_function def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0030414 name: peptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] synonym: "protease inhibitor activity" NARROW [GOC:mah] xref: MIPS_funcat:18.02.01.02.03 is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0061134 ! peptidase regulator activity relationship: negatively_regulates GO:0008233 ! peptidase activity relationship: part_of GO:0010466 ! negative regulation of peptidase activity [Term] id: GO:0030415 name: obsolete carboxypeptidase A inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "carboxypeptidase A inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0030416 name: methylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylamine (CH3NH2)." [ISBN:0721662544] synonym: "methylamine metabolism" EXACT [] synonym: "methylammonium metabolic process" EXACT [] synonym: "methylammonium metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0030417 name: nicotianamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0030418 name: nicotianamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine anabolism" EXACT [] synonym: "nicotianamine biosynthesis" EXACT [] synonym: "nicotianamine formation" EXACT [] synonym: "nicotianamine synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0030419 name: nicotianamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine breakdown" EXACT [] synonym: "nicotianamine catabolism" EXACT [] synonym: "nicotianamine degradation" EXACT [] is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0030420 name: establishment of competence for transformation namespace: biological_process def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027] xref: MIPS_funcat:10.01.01.01 is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0030421 name: defecation namespace: biological_process def: "The expulsion of feces from the rectum." [GOC:mah] xref: Wikipedia:Defecation is_a: GO:0007588 ! excretion [Term] id: GO:0030422 name: production of siRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah] synonym: "RNA interference, production of guide RNAs" EXACT [] synonym: "RNA interference, production of siRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030423 name: targeting of mRNA for destruction involved in RNA interference namespace: biological_process def: "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030424 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1770195789 xref: Wikipedia:Axon is_a: GO:0043005 ! neuron projection [Term] id: GO:0030425 name: dendrite namespace: cellular_component def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1211023249 xref: Wikipedia:Dendrite is_a: GO:0043005 ! neuron projection relationship: part_of GO:0097447 ! dendritic tree [Term] id: GO:0030426 name: growth cone namespace: cellular_component def: "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] xref: Wikipedia:Growth_cone is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0150034 ! distal axon [Term] id: GO:0030427 name: site of polarized growth namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0030429 name: kynureninase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] xref: EC:3.7.1.3 xref: MetaCyc:KYNURENINASE-RXN xref: Reactome:R-HSA-71217 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine" xref: RHEA:16813 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030430 name: host cell cytoplasm namespace: cellular_component alt_id: GO:0097679 def: "The cytoplasm of a host cell." [GOC:mah] synonym: "other organism cytoplasm" RELATED [] is_a: GO:0033646 ! host intracellular part created_by: paola creation_date: 2014-12-01T14:14:21Z [Term] id: GO:0030431 name: sleep namespace: biological_process def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] subset: goslim_pir synonym: "diapause" RELATED [] synonym: "dormancy" RELATED [] synonym: "lethargus" RELATED [] xref: Wikipedia:Sleep is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030432 name: peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732] xref: Wikipedia:Peristalsis is_a: GO:0014821 ! phasic smooth muscle contraction [Term] id: GO:0030433 name: ubiquitin-dependent ERAD pathway namespace: biological_process def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process" EXACT [] synonym: "endoplasmic reticulum-associated ubiqutin-dependent protein catabolism" EXACT [] synonym: "ER-associated ubiquitin-dependent protein breakdown" EXACT [] synonym: "ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] synonym: "ER-associated ubiquitin-dependent protein catabolism" EXACT [] synonym: "ER-associated ubiquitin-dependent protein degradation" EXACT [] synonym: "ERAD" BROAD [] synonym: "ubiquitin-dependent proteasomal protein catabolism of ER proteins" EXACT [GOC:bf] is_a: GO:0036503 ! ERAD pathway is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0030154 ! cell differentiation is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0030436 name: asexual sporulation namespace: biological_process def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886] subset: goslim_aspergillus synonym: "asexual reproductive sporulation" EXACT [] synonym: "asexual spore formation" EXACT [] synonym: "mitotic spore formation" EXACT [] synonym: "mitotic sporulation" EXACT [] xref: MIPS_funcat:43.01.02.05.01 is_a: GO:0019954 ! asexual reproduction is_a: GO:0043934 ! sporulation [Term] id: GO:0030437 name: ascospore formation namespace: biological_process alt_id: GO:0007151 def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0030438 name: obsolete MAPKKK cascade during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030439 name: obsolete activation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030440 name: obsolete activation of MAPKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030441 name: obsolete activation of MAPKKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030442 name: obsolete inactivation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030443 name: obsolete nuclear translocation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030444 name: obsolete microtubule depolymerization during nuclear congression namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because the entire branch of the ontology was changed. synonym: "microtubule depolymerization during nuclear congression" EXACT [] is_obsolete: true replaced_by: GO:0007019 [Term] id: GO:0030445 name: yeast-form cell wall namespace: cellular_component def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030446 name: hyphal cell wall namespace: cellular_component def: "The cell wall surrounding a fungal hypha." [GOC:mah] comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_aspergillus subset: goslim_candida is_a: GO:0040007 ! growth [Term] id: GO:0030448 name: hyphal growth namespace: biological_process def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida xref: MIPS_funcat:43.01.03.06 xref: MIPS_funcat:47.01.01 is_a: GO:0030447 ! filamentous growth [Term] id: GO:0030449 name: regulation of complement activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade" EXACT [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0002920 ! regulation of humoral immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006956 ! complement activation relationship: regulates GO:0006956 ! complement activation [Term] id: GO:0030450 name: regulation of complement activation, classical pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin is_a: GO:0030449 ! regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006958 ! complement activation, classical pathway relationship: regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0030451 name: regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006957 ! complement activation, alternative pathway relationship: regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0030455 name: obsolete MAPKKK cascade (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030456 name: obsolete activation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030457 name: obsolete activation of MAPKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030458 name: obsolete activation of MAPKKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030459 name: obsolete inactivation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030460 name: obsolete nuclear translocation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030463 name: obsolete cell aging (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. synonym: "cell aging (sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0030464 name: obsolete aging dependent sterility (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. synonym: "aging dependent sterility (sensu Fungi)" EXACT [] is_obsolete: true consider: GO:0030466 [Term] id: GO:0030465 name: obsolete autophagic death (sensu Fungi) namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because a more correct term has been created. synonym: "autophagic death (sensu Fungi)" EXACT [] is_obsolete: true consider: GO:0048102 [Term] id: GO:0030466 name: chromatin silencing at silent mating-type cassette namespace: biological_process alt_id: GO:0006347 def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc] synonym: "aging-dependent sterility" NARROW [] synonym: "chromatin silencing at HML and HMR" NARROW [] synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0030470 name: obsolete spore germination (sensu Fungi) namespace: biological_process alt_id: GO:0007153 def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc] comment: This term was made obsolete because a sensu term was not needed. synonym: "germination (sensu Saccharomyces)" NARROW [] synonym: "spore germination (sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0009847 [Term] id: GO:0030471 name: obsolete spindle pole body and microtubule cycle (sensu Fungi) namespace: biological_process alt_id: GO:0007102 def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. synonym: "spindle pole body and microtubule cycle (sensu Fungi)" EXACT [] synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW [] xref: MIPS_funcat:10.03.05.01 is_obsolete: true consider: GO:0007051 consider: GO:0051300 [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process alt_id: GO:0000065 def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0030474 name: spindle pole body duplication namespace: biological_process alt_id: GO:0007103 alt_id: GO:0031046 def: "Construction of a new spindle pole body." [GOC:clt] synonym: "spindle pole body assembly" EXACT [] synonym: "spindle pole body biogenesis" EXACT [] synonym: "spindle pole body biosynthesis" EXACT [] synonym: "spindle pole body duplication associated with nuclear envelope" EXACT [] synonym: "spindle pole body duplication in cytoplasm" EXACT [] synonym: "spindle pole body formation" EXACT [] synonym: "spindle pole body replication" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0051300 ! spindle pole body organization [Term] id: GO:0030476 name: ascospore wall assembly namespace: biological_process alt_id: GO:0007152 def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385] synonym: "spore wall assembly" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0071940 ! fungal-type cell wall assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0030478 name: actin cap namespace: cellular_component alt_id: GO:0000143 def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, PMID:21494665] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030479 name: actin cortical patch namespace: cellular_component alt_id: GO:0005857 def: "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] synonym: "actin patch" EXACT [] is_a: GO:0061645 ! endocytic patch relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030484 name: obsolete muscle fiber namespace: cellular_component def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'. synonym: "muscle fiber" EXACT [] synonym: "muscle fibre" EXACT [] is_obsolete: true consider: GO:0043292 [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] synonym: "smooth muscle fiber" BROAD [] synonym: "smooth muscle fibre" EXACT [] is_a: GO:0043292 ! contractile fiber [Term] id: GO:0030486 name: smooth muscle dense body namespace: cellular_component def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030485 ! smooth muscle contractile fiber [Term] id: GO:0030487 name: inositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah] is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0030488 name: tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] is_a: GO:0001510 ! RNA methylation is_a: GO:0006400 ! tRNA modification [Term] id: GO:0030489 name: obsolete processing of 27S pre-rRNA namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product. synonym: "processing of 27S pre-rRNA" EXACT [] is_obsolete: true [Term] id: GO:0030490 name: maturation of SSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] synonym: "processing of 20S pre-rRNA" NARROW [] synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0030491 name: heteroduplex formation namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0030492 name: hemoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl] synonym: "globin binding" BROAD [] synonym: "haemoglobin binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0030493 name: bacteriochlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] synonym: "bacteriochlorophyll metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0030494 name: bacteriochlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] synonym: "bacteriochlorophyll anabolism" EXACT [] synonym: "bacteriochlorophyll biosynthesis" EXACT [] synonym: "bacteriochlorophyll formation" EXACT [] synonym: "bacteriochlorophyll synthesis" EXACT [] is_a: GO:0015995 ! chlorophyll biosynthetic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030495 name: bacteriochlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators] synonym: "bacteriochlorophyll breakdown" EXACT [] synonym: "bacteriochlorophyll catabolism" EXACT [] synonym: "bacteriochlorophyll degradation" EXACT [] is_a: GO:0015996 ! chlorophyll catabolic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030496 name: midbody namespace: cellular_component def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Midbody_(cell_biology) is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0030497 name: fatty acid elongation namespace: biological_process def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0030500 name: regulation of bone mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030282 ! bone mineralization relationship: regulates GO:0030282 ! bone mineralization [Term] id: GO:0030501 name: positive regulation of bone mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "activation of bone mineralization" NARROW [] synonym: "stimulation of bone mineralization" NARROW [] synonym: "up regulation of bone mineralization" EXACT [] synonym: "up-regulation of bone mineralization" EXACT [] synonym: "upregulation of bone mineralization" EXACT [] is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0045778 ! positive regulation of ossification is_a: GO:0070169 ! positive regulation of biomineral tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030282 ! bone mineralization relationship: positively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030502 name: negative regulation of bone mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "down regulation of bone mineralization" EXACT [] synonym: "down-regulation of bone mineralization" EXACT [] synonym: "downregulation of bone mineralization" EXACT [] synonym: "inhibition of bone mineralization" NARROW [] is_a: GO:0030279 ! negative regulation of ossification is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0070168 ! negative regulation of biomineral tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030282 ! bone mineralization relationship: negatively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030504 name: inorganic diphosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic diphosphate across a membrane." [PMID:11326272] synonym: "inorganic pyrophosphate transporter activity" EXACT [] xref: Reactome:R-HSA-5226964 "ANKH transports PPi from cytosol to extracellular region" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0030505 ! inorganic diphosphate transport [Term] id: GO:0030505 name: inorganic diphosphate transport namespace: biological_process def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "inorganic pyrophosphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0030506 name: ankyrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030507 name: spectrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0030508 name: obsolete thiol-disulfide exchange intermediate activity namespace: molecular_function def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process. synonym: "glutaredoxin" NARROW [] synonym: "thiol-disulfide exchange intermediate activity" EXACT [] synonym: "thiol-disulphide exchange intermediate activity" EXACT [] synonym: "thioredoxin" NARROW [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 [Term] id: GO:0030509 name: BMP signaling pathway namespace: biological_process alt_id: GO:0008101 def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827, PR:000000034] synonym: "BMP receptor signaling pathway" RELATED [] synonym: "BMP signalling pathway" EXACT [] synonym: "bone morphogenetic protein signaling pathway" EXACT [] synonym: "bone morphogenetic protein signalling pathway" EXACT [] synonym: "decapentaplegic receptor signaling pathway" NARROW [GOC:bf, GOC:sart, GOC:signaling] synonym: "decapentaplegic receptor signalling pathway" NARROW [] synonym: "decapentaplegic signaling pathway" NARROW [] synonym: "dpp receptor signaling pathway" NARROW [] synonym: "dpp receptor signalling pathway" NARROW [] synonym: "dpp signaling pathway" NARROW [GOC:bf] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: part_of GO:0071773 ! cellular response to BMP stimulus [Term] id: GO:0030510 name: regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090097 def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] synonym: "regulation of BMP receptor signaling pathway" RELATED [] synonym: "regulation of BMP signalling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "regulation of decapentaplegic signaling pathway" NARROW [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030509 ! BMP signaling pathway relationship: regulates GO:0030509 ! BMP signaling pathway created_by: tanyaberardini creation_date: 2009-11-13T10:49:14Z [Term] id: GO:0030511 name: positive regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT [] synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903846 ! positive regulation of cellular response to transforming growth factor beta stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030512 name: negative regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903845 ! negative regulation of cellular response to transforming growth factor beta stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030513 name: positive regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090098 def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] synonym: "activation of BMP signaling pathway" NARROW [] synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] synonym: "positive regulation of BMP signalling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "positive regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "positive regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "positive regulation of decapentaplegic signaling pathway" NARROW [] synonym: "stimulation of BMP signaling pathway" NARROW [] synonym: "up regulation of BMP signaling pathway" EXACT [] synonym: "up-regulation of BMP signaling pathway" EXACT [] synonym: "upregulation of BMP signaling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030509 ! BMP signaling pathway relationship: positively_regulates GO:0030509 ! BMP signaling pathway created_by: tanyaberardini creation_date: 2009-11-13T10:50:41Z [Term] id: GO:0030514 name: negative regulation of BMP signaling pathway namespace: biological_process alt_id: GO:0090099 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] synonym: "down regulation of BMP signaling pathway" EXACT [] synonym: "down-regulation of BMP signaling pathway" EXACT [] synonym: "downregulation of BMP signaling pathway" EXACT [] synonym: "inhibition of BMP signaling pathway" NARROW [] synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] synonym: "negative regulation of BMP signalling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "negative regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] synonym: "negative regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] synonym: "negative regulation of decapentaplegic signaling pathway" NARROW [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030509 ! BMP signaling pathway relationship: negatively_regulates GO:0030509 ! BMP signaling pathway created_by: tanyaberardini creation_date: 2009-11-13T10:51:30Z [Term] id: GO:0030515 name: snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0030516 name: regulation of axon extension namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048675 ! axon extension relationship: regulates GO:0048675 ! axon extension [Term] id: GO:0030517 name: negative regulation of axon extension namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] synonym: "down regulation of axon extension" EXACT [] synonym: "down-regulation of axon extension" EXACT [] synonym: "downregulation of axon extension" EXACT [] synonym: "inhibition of axon extension" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0050771 ! negative regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048675 ! axon extension relationship: negatively_regulates GO:0048675 ! axon extension [Term] id: GO:0030518 name: intracellular steroid hormone receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling] synonym: "steroid hormone receptor signaling pathway" BROAD [GOC:bf] synonym: "steroid hormone receptor signalling pathway" BROAD [GOC:bf] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0043401 ! steroid hormone mediated signaling pathway [Term] id: GO:0030519 name: snoRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0030520 name: intracellular estrogen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)." [GOC:mah, GOC:signaling] synonym: "estrogen receptor signaling pathway" BROAD [GOC:bf] synonym: "estrogen receptor signalling pathway" BROAD [GOC:bf] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0030521 name: androgen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] synonym: "androgen receptor signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0030522 name: intracellular receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] synonym: "intracellular receptor mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0030523 name: dihydrolipoamide S-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] xref: EC:2.3.1.12 is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0030526 name: granulocyte macrophage colony-stimulating factor receptor complex namespace: cellular_component def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] synonym: "GM-CSF receptor complex" EXACT [GOC:vk] synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT [] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030527 name: structural constituent of chromatin namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0000785 ! chromatin relationship: occurs_in GO:0000785 ! chromatin [Term] id: GO:0030528 name: obsolete transcription regulator activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription regulator activity" EXACT [] synonym: "transcriptional regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0140110 [Term] id: GO:0030530 name: obsolete heterogeneous nuclear ribonucleoprotein complex namespace: cellular_component def: "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732] comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity. synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "heterogeneous nuclear ribonucleoprotein complex" EXACT [] synonym: "hnRNP" EXACT [] xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle is_obsolete: true consider: GO:0005681 consider: GO:1990904 [Term] id: GO:0030531 name: obsolete small cytoplasmic ribonucleoprotein complex namespace: cellular_component def: "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] comment: This term was made obsolete because we are unsure what it is supposed to represent, it has no annotations and the only references to the phrase in the literature are old. synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] synonym: "small cytoplasmic ribonucleoprotein complex" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0030532 name: small nuclear ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] xref: Wikipedia:SnRNP is_a: GO:0120114 ! Sm-like protein family complex is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0003729 ! mRNA binding is_a: GO:0060090 ! molecular adaptor activity relationship: part_of GO:0006412 ! translation [Term] id: GO:0030534 name: adult behavior namespace: biological_process def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "adult behavioral response to stimulus" EXACT [] synonym: "adult behaviour" EXACT [] synonym: "adult behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030535 name: obsolete adult feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "adult feeding behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0008343 [Term] id: GO:0030536 name: larval feeding behavior namespace: biological_process def: "Feeding behavior in a larval (immature) organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "larval feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0030537 name: larval behavior namespace: biological_process alt_id: GO:0017037 def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "larval behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030538 name: embryonic genitalia morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] synonym: "embryonic genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis [Term] id: GO:0030539 name: male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] synonym: "male genital development" EXACT [] is_a: GO:0048806 ! genitalia development is_a: GO:0061458 ! reproductive system development relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0030540 name: female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] synonym: "female genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0030541 name: plasmid partitioning namespace: biological_process alt_id: GO:0030542 def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah] is_a: GO:0006276 ! plasmid maintenance [Term] id: GO:0030543 name: 2-micrometer plasmid partitioning namespace: biological_process def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah] is_a: GO:0030541 ! plasmid partitioning [Term] id: GO:0030544 name: Hsp70 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0030545 name: receptor regulator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] xref: MIPS_funcat:18.02.07 is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0030546 name: signaling receptor activator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] synonym: "receptor activator activity" BROAD [] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030547 name: receptor inhibitor activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb] is_a: GO:0030545 ! receptor regulator activity relationship: negatively_regulates GO:0038023 ! signaling receptor activity relationship: part_of GO:2000272 ! negative regulation of signaling receptor activity [Term] id: GO:0030548 name: acetylcholine receptor regulator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] is_a: GO:0099602 ! neurotransmitter receptor regulator activity relationship: regulates GO:0015464 ! acetylcholine receptor activity [Term] id: GO:0030549 name: acetylcholine receptor activator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] is_a: GO:0030546 ! signaling receptor activator activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030550 name: acetylcholine receptor inhibitor activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah] is_a: GO:0030547 ! receptor inhibitor activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030551 name: cyclic nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] xref: MIPS_funcat:16.19.01 is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0030552 name: cAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cAMP binding" EXACT [] synonym: "3',5'-cAMP binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] synonym: "cyclic AMP binding" EXACT [] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0030553 name: cGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cGMP binding" EXACT [] synonym: "3',5'-cGMP binding" EXACT [] synonym: "cyclic GMP binding" EXACT [] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0030555 name: RNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. subset: goslim_generic subset: goslim_yeast is_a: GO:0003723 ! RNA binding [Term] id: GO:0030556 name: rRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0019843 ! rRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030557 name: tRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000049 ! tRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030558 name: RNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030559 name: rRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030560 name: tRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030561 name: RNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030562 name: rRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030563 name: snRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030564 name: tRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030565 name: snRNA pseudouridylation guide activity namespace: molecular_function def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030558 ! RNA pseudouridylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030566 name: snRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0017069 ! snRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030567 name: obsolete thrombin activator activity namespace: molecular_function def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb] synonym: "thrombin activator activity" EXACT [] is_obsolete: true replaced_by: GO:0016504 [Term] id: GO:0030568 name: obsolete plasmin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "plasmin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030569 name: obsolete chymotrypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term. synonym: "chymotrypsin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030570 name: pectate lyase activity namespace: molecular_function def: "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2] synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2] synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] synonym: "PGA lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2] synonym: "PPase-N activity" EXACT [EC:4.2.2.2] xref: EC:4.2.2.2 xref: MetaCyc:4.2.2.2-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030572 name: phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0030573 name: bile acid catabolic process namespace: biological_process alt_id: GO:0019613 def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] synonym: "bile acid breakdown" EXACT [] synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] xref: MetaCyc:7ALPHADEHYDROX-PWY is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0032963 ! collagen metabolic process [Term] id: GO:0030575 name: nuclear body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "nuclear body organisation" EXACT [] synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0030576 name: Cajal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] comment: See also the cellular component term 'Cajal body ; GO:0015030'. synonym: "Cajal body organisation" EXACT [] synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030577 name: Lands organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863] comment: See also the cellular component term 'Lands ; GO:0016606'. synonym: "Lands organisation" EXACT [] synonym: "Lands organization and biogenesis" RELATED [GOC:mah] synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030578 name: PML body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078] comment: See also the cellular component term 'PML body ; GO:0016605'. synonym: "PML body organisation" EXACT [] synonym: "PML body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030579 name: ubiquitin-dependent SMAD protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators] synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT [] synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT [] synonym: "ubiquitin-dependent SMAD protein degradation" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0030580 name: quinone cofactor methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030581 name: symbiont intracellular protein transport in host namespace: biological_process alt_id: GO:0051708 def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell protein transport" EXACT [] synonym: "intracellular protein transport in host" EXACT [] synonym: "intracellular protein transport in other organism during symbiotic interaction" BROAD [GOC:dph] synonym: "intracellular protein transport in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0015031 ! protein transport is_a: GO:0044766 ! multi-organism transport is_a: GO:0051701 ! interaction with host intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0043657 ! host cell relationship: occurs_in GO:0043657 ! host cell [Term] id: GO:0030582 name: reproductive fruiting body development namespace: biological_process def: "The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores." [GOC:mah, GOC:mtg_sensu] comment: This term describes the development of a fruiting body that is a spore-bearing organ. It is not intended to describe the development of myxococcal fruiting bodies. synonym: "fruiting body formation" EXACT [] xref: MIPS_funcat:41.01.03.01 is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0030583 name: myxococcal fruiting body development namespace: biological_process alt_id: GO:0055084 def: "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786] comment: For example, as seen in myxobacterium. It is not intended to describe fruiting body development as is Dictyostelium. synonym: "fruiting body development in cellular response to starvation" BROAD [] synonym: "fruiting body development in response to starvation" BROAD [] is_a: GO:0042594 ! response to starvation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0030584 name: sporocarp development namespace: biological_process def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu] synonym: "fruiting body development" BROAD [] xref: MIPS_funcat:47.01.03.01 is_a: GO:0030582 ! reproductive fruiting body development disjoint_from: GO:0030587 ! sorocarp development [Term] id: GO:0030585 name: phosphoenolpyruvate carboxykinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22356] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38] synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "PEPCTrP" RELATED [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] xref: EC:4.1.1.38 xref: KEGG_REACTION:R00346 xref: MetaCyc:4.1.1.38-RXN xref: RHEA:22356 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0030586 name: [methionine synthase] reductase activity namespace: molecular_function def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] comment: Note that this was EC:2.1.1.135. synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8] synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8] xref: EC:1.16.1.8 xref: MetaCyc:2.1.1.135-RXN xref: Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl" is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0030587 name: sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4332228] synonym: "fruiting body development" BROAD [] synonym: "fruiting body formation" BROAD [] synonym: "sorocarp biosynthesis" EXACT [] synonym: "sorocarp formation" EXACT [] is_a: GO:0090702 ! non-reproductive fruiting body development [Term] id: GO:0030588 name: pseudocleavage namespace: biological_process def: "Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:30990821, PMID:7729583] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0030589 name: pseudocleavage involved in syncytial blastoderm formation namespace: biological_process def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph] is_a: GO:0030588 ! pseudocleavage relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0030590 name: first cell cycle pseudocleavage namespace: biological_process def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583] is_a: GO:0030588 ! pseudocleavage [Term] id: GO:0030591 name: 2'-deoxyguanosine DNA ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] synonym: "NAD DNA ADP-ribosyltransferase activity" BROAD [] is_a: GO:0140294 ! NAD DNA ADP-ribosyltransferase activity [Term] id: GO:0030592 name: DNA ADP-ribosylation namespace: biological_process def: "The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA." [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010] comment: Updated definition as requested in https://github.com/geneontology/go-ontology/issues/16614 is_a: GO:0006304 ! DNA modification [Term] id: GO:0030593 name: neutrophil chemotaxis namespace: biological_process def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732] is_a: GO:0071621 ! granulocyte chemotaxis is_a: GO:1990266 ! neutrophil migration [Term] id: GO:0030594 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0042165 ! neurotransmitter binding [Term] id: GO:0030595 name: leukocyte chemotaxis namespace: biological_process def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] synonym: "immune cell chemotaxis" EXACT [] synonym: "leucocyte chemotaxis" EXACT [] is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0030596 name: alpha-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40] xref: EC:3.2.1.40 xref: MetaCyc:3.2.1.40-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030597 name: RNA glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0030598 name: rRNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] synonym: "gelonin" RELATED [EC:3.2.2.22] synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] synonym: "momorcochin-S" RELATED [EC:3.2.2.22] synonym: "nigrin b" RELATED [EC:3.2.2.22] synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "ricin" RELATED [EC:3.2.2.22] synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycosidase activity" EXACT [] synonym: "saporins" RELATED [EC:3.2.2.22] xref: EC:3.2.2.22 xref: MetaCyc:3.2.2.22-RXN is_a: GO:0030597 ! RNA glycosylase activity is_a: GO:0140102 ! catalytic activity, acting on a rRNA [Term] id: GO:0030599 name: pectinesterase activity namespace: molecular_function def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] synonym: "pectase activity" EXACT [EC:3.1.1.11] synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11] synonym: "pectin methylesterase activity" EXACT [] synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] xref: EC:3.1.1.11 xref: MetaCyc:PECTINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030600 name: feruloyl esterase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73] synonym: "cinnAE" RELATED [EC:3.1.1.73] synonym: "cinnamoyl ester hydrolase activity" EXACT [] synonym: "FAE-I" RELATED [EC:3.1.1.73] synonym: "FAE-II" RELATED [EC:3.1.1.73] synonym: "FAE-III" RELATED [EC:3.1.1.73] synonym: "FAEA" RELATED [EC:3.1.1.73] synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73] synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73] xref: EC:3.1.1.73 xref: MetaCyc:3.1.1.73-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030601 name: obsolete aminopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase B activity" EXACT [] synonym: "arginyl aminopeptidase activity" EXACT [] synonym: "arylamidase II" RELATED [EC:3.4.11.6] synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] xref: EC:3.4.11.6 xref: MetaCyc:3.4.11.6-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0030602 name: obsolete chymosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] comment: This term was made obsolete because it represents a gene product. synonym: "chymosin activity" EXACT [] synonym: "rennin" RELATED [EC:3.4.23.4] synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] xref: EC:3.4.23.4 xref: MetaCyc:3.4.23.4-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0030603 name: oxaloacetase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24432] synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1] synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1] xref: EC:3.7.1.1 xref: KEGG_REACTION:R00338 xref: MetaCyc:OXALOACETASE-RXN xref: RHEA:24432 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030604 name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13717] synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267] synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267] synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267] synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267] synonym: "DOXP reductoisomerase activity" EXACT [] synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267] xref: EC:1.1.1.267 xref: KEGG_REACTION:R05688 xref: MetaCyc:DXPREDISOM-RXN xref: RHEA:13717 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030611 name: arsenate reductase activity namespace: molecular_function def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030612 name: arsenate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737] xref: MetaCyc:RXN-10737 is_a: GO:0030611 ! arsenate reductase activity [Term] id: GO:0030613 name: oxidoreductase activity, acting on phosphorus or arsenic in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] xref: EC:1.20 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030614 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] xref: EC:1.20.4 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0030616 name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family. synonym: "co-SMAD protein" RELATED [GOC:rl] synonym: "common mediator SMAD protein" RELATED [GOC:rl] synonym: "common partner SMAD protein" RELATED [GOC:rl] synonym: "common-mediator SMAD protein" RELATED [GOC:rl] synonym: "common-partner SMAD protein" RELATED [] synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030617 name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family. synonym: "inhibitory SMAD protein" RELATED [] synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030618 name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family. synonym: "pathway restricted SMAD protein" RELATED [GOC:rl] synonym: "pathway-restricted SMAD protein" RELATED [GOC:rl] synonym: "pathway-specific SMAD protein" RELATED [] synonym: "receptor regulated SMAD protein" RELATED [GOC:rl] synonym: "receptor-regulated SMAD protein" RELATED [GOC:rl] synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030619 name: U1 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030620 name: U2 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030621 name: U4 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030622 name: U4atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030623 name: U5 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030624 name: U6atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030625 name: U11 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030626 name: U12 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030627 name: pre-mRNA 5'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [GOC:jl] synonym: "pre-mRNA 5' splice site binding" EXACT [] is_a: GO:0036002 ! pre-mRNA binding [Term] id: GO:0030628 name: pre-mRNA 3'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl] synonym: "pre-mRNA 3' splice site binding" EXACT [] is_a: GO:0036002 ! pre-mRNA binding [Term] id: GO:0030629 name: U6 snRNA 3'-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). synonym: "U6 snRNA 3' end binding" EXACT [] is_a: GO:0017070 ! U6 snRNA binding [Term] id: GO:0030631 name: pyrrolysine incorporation namespace: biological_process def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321] synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321] synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [] xref: RESID:AA0321 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0030632 name: D-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [GOC:jsg, GOC:mah] synonym: "D-alanine anabolism" EXACT [] synonym: "D-alanine biosynthesis" EXACT [] synonym: "D-alanine formation" EXACT [] synonym: "D-alanine synthesis" EXACT [] is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process is_a: GO:0046436 ! D-alanine metabolic process is_a: GO:0046437 ! D-amino acid biosynthetic process [Term] id: GO:0030633 name: D-alanine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah] synonym: "D-alanine family amino acid breakdown" EXACT [] synonym: "D-alanine family amino acid catabolism" EXACT [] synonym: "D-alanine family amino acid degradation" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process [Term] id: GO:0030634 name: carbon fixation by acetyl-CoA pathway namespace: biological_process def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093] synonym: "acetyl CoA pathway" RELATED [GOC:cjm, PMID:14602585] synonym: "Ljungdahl-Wood pathway" EXACT [] synonym: "reductive acetyl CoA pathway" EXACT [GOC:cjm, PMID:18801467] xref: MetaCyc:CODH-PWY xref: MIPS_funcat:01.05.01.05.07 xref: Wikipedia:Wood-Ljungdahl_pathway is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0015977 ! carbon fixation [Term] id: GO:0030635 name: obsolete acetate derivative metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah] comment: This term was made obsolete because it is an unnecessary grouping term, and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative metabolic process" EXACT [] synonym: "acetate derivative metabolism" EXACT [] is_obsolete: true consider: GO:1900619 [Term] id: GO:0030636 name: obsolete acetate derivative biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah] comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative anabolism" EXACT [] synonym: "acetate derivative biosynthesis" EXACT [] synonym: "acetate derivative biosynthetic process" EXACT [] synonym: "acetate derivative formation" EXACT [] synonym: "acetate derivative synthesis" EXACT [] xref: MIPS_funcat:01.20.05 is_obsolete: true consider: GO:1900620 [Term] id: GO:0030637 name: obsolete acetate derivative catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai] comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative breakdown" EXACT [] synonym: "acetate derivative catabolic process" EXACT [] synonym: "acetate derivative catabolism" EXACT [] synonym: "acetate derivative degradation" EXACT [] is_obsolete: true [Term] id: GO:0030638 name: polyketide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0030639 name: polyketide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide anabolism" EXACT [] synonym: "polyketide biosynthesis" EXACT [] synonym: "polyketide formation" EXACT [] synonym: "polyketide synthesis" EXACT [] xref: MIPS_funcat:01.20.05.11 is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0030640 name: polyketide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide breakdown" EXACT [] synonym: "polyketide catabolism" EXACT [] synonym: "polyketide degradation" EXACT [] is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0030641 name: regulation of cellular pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "proton homeostasis" EXACT [] xref: MIPS_funcat:34.01.01.03 is_a: GO:0006885 ! regulation of pH is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis [Term] id: GO:0030642 name: cellular sulfate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah] synonym: "sulphate ion homeostasis" BROAD [] xref: MIPS_funcat:34.01.03.01 is_a: GO:0055063 ! sulfate ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis [Term] id: GO:0030643 name: cellular phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah] xref: MIPS_funcat:34.01.03.03 is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0055062 ! phosphate ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis is_a: GO:0072502 ! cellular trivalent inorganic anion homeostasis [Term] id: GO:0030644 name: cellular chloride ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah] xref: MIPS_funcat:34.01.03.05 is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0055064 ! chloride ion homeostasis [Term] id: GO:0030645 name: glucose catabolic process to butyrate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732] synonym: "butyrate fermentation" EXACT [] synonym: "glucose fermentation to butyrate" EXACT [] xref: MIPS_funcat:02.16.05 is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006113 ! fermentation is_a: GO:1902705 ! hexose catabolic process to butyrate [Term] id: GO:0030647 name: aminoglycoside antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030648 name: aminoglycoside antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic anabolism" EXACT [] synonym: "aminoglycoside antibiotic biosynthesis" EXACT [] synonym: "aminoglycoside antibiotic formation" EXACT [] synonym: "aminoglycoside antibiotic synthesis" EXACT [] xref: MIPS_funcat:01.20.01.09 is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030649 name: aminoglycoside antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic breakdown" EXACT [] synonym: "aminoglycoside antibiotic catabolism" EXACT [] synonym: "aminoglycoside antibiotic degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030650 name: peptide antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030651 name: peptide antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic anabolism" EXACT [] synonym: "peptide antibiotic biosynthesis" EXACT [] synonym: "peptide antibiotic formation" EXACT [] synonym: "peptide antibiotic synthesis" EXACT [] xref: MIPS_funcat:01.20.37.03 is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0030652 name: peptide antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic breakdown" EXACT [] synonym: "peptide antibiotic catabolism" EXACT [] synonym: "peptide antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0030653 name: beta-lactam antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0072338 ! cellular lactam metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0030654 name: beta-lactam antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic anabolism" EXACT [] synonym: "beta-lactam antibiotic biosynthesis" EXACT [] synonym: "beta-lactam antibiotic formation" EXACT [] synonym: "beta-lactam antibiotic synthesis" EXACT [] xref: MIPS_funcat:01.20.37.05 is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072339 ! cellular lactam biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0030655 name: beta-lactam antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic breakdown" EXACT [] synonym: "beta-lactam antibiotic catabolism" EXACT [] synonym: "beta-lactam antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030656 name: regulation of vitamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] synonym: "regulation of vitamin metabolism" EXACT [] xref: MIPS_funcat:01.07.07 is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006766 ! vitamin metabolic process relationship: regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0030657 name: obsolete regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0051196 consider: GO:0051199 [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0030661 name: chitosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a chitosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0045009 ! chitosome [Term] id: GO:0030662 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030135 ! coated vesicle [Term] id: GO:0030663 name: COPI-coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] synonym: "COPI coated vesicle membrane" EXACT [GOC:sl] is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030665 name: clathrin-coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl] is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030666 name: endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030139 ! endocytic vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030141 ! secretory granule [Term] id: GO:0030668 name: merozoite dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0020026 ! merozoite dense granule [Term] id: GO:0030669 name: clathrin-coated endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] is_a: GO:0030665 ! clathrin-coated vesicle membrane is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle [Term] id: GO:0030670 name: phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] synonym: "phagosome membrane" EXACT [GOC:mah] is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045335 ! phagocytic vesicle [Term] id: GO:0030671 name: clathrin-coated phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane is_a: GO:0030670 ! phagocytic vesicle membrane relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle [Term] id: GO:0030672 name: synaptic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] subset: goslim_synapse is_a: GO:0099501 ! exocytic vesicle membrane relationship: part_of GO:0008021 ! synaptic vesicle [Term] id: GO:0030673 name: axolemma namespace: cellular_component def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] synonym: "axonal membrane" EXACT [GOC:vk] xref: NIF_Subcellular:sao250772229 xref: Wikipedia:Axolemma is_a: GO:0032589 ! neuron projection membrane relationship: part_of GO:0044304 ! main axon [Term] id: GO:0030674 name: protein binding, bridging namespace: molecular_function def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "protein-protein adaptor" NARROW [] is_a: GO:0005515 ! protein binding is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0030676 name: Rac guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:R-HSA-399938 "Activation of Rac1 by FARP2" xref: Reactome:R-HSA-428535 "Activation of RAC1 by SOS" xref: Reactome:R-HSA-9032798 "DOCK3 activates RAC1" xref: Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1" xref: Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1" is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity is_a: GO:0048365 ! Rac GTPase binding [Term] id: GO:0030677 name: ribonuclease P complex namespace: cellular_component def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. subset: goslim_pir synonym: "RNase P complex" EXACT [] is_a: GO:1902555 ! endoribonuclease complex is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030678 name: mitochondrial ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094] synonym: "mitochondrial RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0030677 ! ribonuclease P complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0030679 name: cyanelle ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "cyanelle RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex intersection_of: GO:0030677 ! ribonuclease P complex intersection_of: part_of GO:0009842 ! cyanelle relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0030680 name: dimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094] synonym: "dimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030681 name: multimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094] synonym: "multimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030682 name: mitigation of host defenses by symbiont namespace: biological_process alt_id: GO:0044413 alt_id: GO:0044415 alt_id: GO:0051807 alt_id: GO:0051832 alt_id: GO:0051834 def: "A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "avoidance of defenses of other organism involved in symbiotic interaction" NARROW [] synonym: "avoidance of host defences" NARROW [] synonym: "avoidance of host defenses" NARROW [] synonym: "evasion of host defence response" NARROW [] synonym: "evasion of other organism defence response" NARROW [] synonym: "evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "evasion or tolerance of defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "evasion or tolerance of defenses of other organism" RELATED [] synonym: "evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "evasion or tolerance of defenses of other organism involved in symbiotic interaction" RELATED [] synonym: "evasion or tolerance of host defense response" NARROW [] synonym: "evasion or tolerance of host defenses" RELATED [] is_a: GO:0052200 ! response to host defenses [Term] id: GO:0030683 name: mitigation of host immune response by virus namespace: biological_process alt_id: GO:0019052 alt_id: GO:0019053 def: "A process by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah, GOC:pk] synonym: "evasion by virus of host immune response" NARROW [GOC:bf, GOC:bm, GOC:jl] synonym: "evasion or tolerance by virus of host immune response" RELATED [] synonym: "inhibition of extracellular antiviral response" EXACT [] synonym: "mitigation by virus of host immune response" EXACT [] synonym: "negative regulation by virus of extracellular antiviral response" EXACT [] synonym: "negative regulation by virus of intracellular antiviral response" EXACT [] synonym: "negative regulation of host extracellular antiviral response by virus" EXACT [] synonym: "negative regulation of host intracellular antiviral response by virus" EXACT [] synonym: "suppression by virus of host extracellular antiviral response" EXACT [] synonym: "suppression by virus of host immune response" NARROW [GOC:bf] synonym: "suppression by virus of host intracellular antiviral response" EXACT [] synonym: "suppression of host extracellular antiviral response by virus" EXACT [] synonym: "suppression of host intracellular antiviral response by virus" EXACT [] synonym: "viral inhibition of intracellular antiviral response" EXACT [] is_a: GO:0019049 ! mitigation of host defenses by virus is_a: GO:0050690 ! regulation of defense response to virus by virus [Term] id: GO:0030684 name: preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] subset: goslim_pir is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030685 name: nucleolar preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] is_a: GO:0030684 ! preribosome intersection_of: GO:0030684 ! preribosome intersection_of: part_of GO:0005730 ! nucleolus relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0030686 name: 90S preribosome namespace: cellular_component def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992] is_a: GO:0030684 ! preribosome relationship: has_part GO:0034455 ! t-UTP complex [Term] id: GO:0030687 name: preribosome, large subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] comment: Note that this complex is 66S in Saccharomyces. synonym: "66S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030688 name: preribosome, small subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] comment: Note that this complex is 43S in Saccharomyces. synonym: "43S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030689 name: Noc complex namespace: cellular_component def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0030690 name: Noc1p-Noc2p complex namespace: cellular_component def: "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030691 name: Noc2p-Noc3p complex namespace: cellular_component def: "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030692 name: Noc4p-Nop14p complex namespace: cellular_component def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah] synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671] is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030688 ! preribosome, small subunit precursor [Term] id: GO:0030693 name: obsolete caspase activity namespace: molecular_function alt_id: GO:0004199 def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] comment: This term was made obsolete because it represents a gene product. synonym: "caspase activity" EXACT [] synonym: "caspase-1 activity" NARROW [] synonym: "caspase-10 activity" NARROW [] synonym: "caspase-2 activity" NARROW [] synonym: "caspase-3 activity" NARROW [] synonym: "caspase-4 activity" NARROW [] synonym: "caspase-5 activity" NARROW [] synonym: "caspase-6 activity" NARROW [] synonym: "caspase-7 activity" NARROW [] synonym: "caspase-8 activity" NARROW [] synonym: "caspase-9 activity" NARROW [] synonym: "effector caspase activity" NARROW [] synonym: "signaling (initiator) caspase activity" NARROW [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0030694 name: bacterial-type flagellum basal body, rod namespace: cellular_component def: "The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, rod" EXACT [] synonym: "flagellin-based flagellum basal body, rod" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0030695 name: GTPase regulator activity namespace: molecular_function alt_id: GO:0005083 def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] synonym: "small GTPase regulator activity" RELATED [] synonym: "small GTPase regulatory/interacting protein activity" RELATED [] is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity relationship: regulates GO:0003924 ! GTPase activity [Term] id: GO:0030696 name: tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337] comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. synonym: "RUMT" EXACT [] is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0030697 name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function alt_id: GO:0009021 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337] synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] synonym: "RUMT" BROAD [] synonym: "RUMT activity" EXACT [EC:2.1.1.35] synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] synonym: "tRNA (uracil-5-)-methyltransferase activity" EXACT [] synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity [Term] id: GO:0030698 name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337] synonym: "RUMT" BROAD [] is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0030699 name: glycine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12232] synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2] xref: EC:1.21.4.2 xref: KEGG_REACTION:R07226 xref: MetaCyc:RXN-7566 xref: RHEA:12232 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0030700 name: glycine reductase complex namespace: cellular_component def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0030701 name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.37 xref: MetaCyc:2.4.2.37-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0030702 name: chromatin silencing at centromere namespace: biological_process def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah] synonym: "centromere chromatin silencing" EXACT [GOC:mah] synonym: "centromeric silencing" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere" EXACT [] is_a: GO:0006342 ! chromatin silencing intersection_of: GO:0006342 ! chromatin silencing intersection_of: occurs_in GO:0000775 ! chromosome, centromeric region relationship: occurs_in GO:0000775 ! chromosome, centromeric region [Term] id: GO:0030703 name: eggshell formation namespace: biological_process def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030704 name: vitelline membrane formation namespace: biological_process def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0035803 ! egg coat formation is_a: GO:0085029 ! extracellular matrix assembly [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic xref: MIPS_funcat:20.09.14 is_a: GO:0046907 ! intracellular transport [Term] id: GO:0030706 name: germarium-derived oocyte differentiation namespace: biological_process def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte cell differentiation" RELATED [] is_a: GO:0009994 ! oocyte differentiation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030707 name: ovarian follicle cell development namespace: biological_process def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030708 name: germarium-derived female germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] is_a: GO:0048139 ! female germ-line cyst encapsulation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030709 name: border follicle cell delamination namespace: biological_process def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] synonym: "border cell delamination" BROAD [] is_a: GO:0022414 ! reproductive process is_a: GO:0060232 ! delamination relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030710 name: regulation of border follicle cell delamination namespace: biological_process def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "regulation of border cell delamination" BROAD [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030709 ! border follicle cell delamination relationship: regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030711 name: positive regulation of border follicle cell delamination namespace: biological_process def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "activation of border follicle cell delamination" NARROW [] synonym: "positive regulation of border cell delamination" BROAD [] synonym: "stimulation of border follicle cell delamination" NARROW [] synonym: "up regulation of border follicle cell delamination" EXACT [] synonym: "up-regulation of border follicle cell delamination" EXACT [] synonym: "upregulation of border follicle cell delamination" EXACT [] is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:1905881 ! positive regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030709 ! border follicle cell delamination relationship: positively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030712 name: negative regulation of border follicle cell delamination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "down regulation of border follicle cell delamination" EXACT [] synonym: "down-regulation of border follicle cell delamination" EXACT [] synonym: "downregulation of border follicle cell delamination" EXACT [] synonym: "inhibition of border follicle cell delamination" NARROW [] synonym: "negative regulation of border cell delamination" BROAD [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1905880 ! negative regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030709 ! border follicle cell delamination relationship: negatively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030713 name: ovarian follicle cell stalk formation namespace: biological_process def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030714 name: anterior/posterior axis specification, follicular epithelium namespace: biological_process def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030715 name: oocyte growth in germarium-derived egg chamber namespace: biological_process def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0001555 ! oocyte growth relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber [Term] id: GO:0030716 name: oocyte fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "oocyte cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination [Term] id: GO:0030717 name: oocyte karyosome formation namespace: biological_process def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] is_a: GO:0061988 ! karyosome formation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030718 name: germ-line stem cell population maintenance namespace: biological_process def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] is_a: GO:0019827 ! stem cell population maintenance [Term] id: GO:0030719 name: P granule organization namespace: biological_process alt_id: GO:0048114 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] synonym: "P granule organization and biogenesis" RELATED [] synonym: "polar granule organisation" EXACT [] synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006996 ! organelle organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0051674 ! localization of cell relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030721 name: spectrosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] synonym: "spectrosome organisation" EXACT [] synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0030723 name: ovarian fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "ovarian fusome organisation" EXACT [] synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030724 name: testicular fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "testicular fusome organisation" EXACT [] synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030725 name: germline ring canal formation namespace: biological_process def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] synonym: "ring canal formation" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0043063 ! intercellular bridge organization [Term] id: GO:0030726 name: male germline ring canal formation namespace: biological_process def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] synonym: "spermatocyte ring canal formation" NARROW [] synonym: "testicular ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030727 name: germarium-derived female germ-line cyst formation namespace: biological_process def: "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] synonym: "germarium-derived female germline cyst formation" EXACT [] is_a: GO:0048135 ! female germ-line cyst formation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030728 name: ovulation namespace: biological_process def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] xref: Wikipedia:Ovulation is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0030729 name: acetoacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16117] synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16] synonym: "acetoacetyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1.16 xref: KEGG_REACTION:R01357 xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN xref: Reactome:R-HSA-5694494 "AACS ligates CoA-SH to ACA, forming ACA-CoA" xref: RHEA:16117 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0030730 name: sequestering of triglyceride namespace: biological_process def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] synonym: "retention of triacylglycerol" EXACT [] synonym: "retention of triglyceride" EXACT [] synonym: "sequestering of triacylglycerol" EXACT [] synonym: "sequestration of triacylglycerol" EXACT [] synonym: "sequestration of triglyceride" EXACT [] synonym: "storage of triacylglycerol" EXACT [] synonym: "storage of triglyceride" EXACT [] synonym: "triacylglycerol retention" EXACT [] synonym: "triacylglycerol sequestering" EXACT [] synonym: "triacylglycerol sequestration" EXACT [] synonym: "triacylglycerol storage" EXACT [] synonym: "triglyceride retention" EXACT [] synonym: "triglyceride sequestering" EXACT [] synonym: "triglyceride sequestration" EXACT [] synonym: "triglyceride storage" EXACT [] is_a: GO:0019915 ! lipid storage [Term] id: GO:0030731 name: guanidinoacetate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10656] synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2] synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2] synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] xref: EC:2.1.1.2 xref: KEGG_REACTION:R01883 xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN xref: RHEA:10656 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030732 name: methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12] xref: EC:2.1.1.12 xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN xref: RHEA:13761 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030733 name: fatty acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "fatty-acid O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] xref: EC:2.1.1.15 xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030734 name: polysaccharide O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18] xref: EC:2.1.1.18 xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030735 name: carnosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14205] synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22] xref: EC:2.1.1.22 xref: KEGG_REACTION:R02144 xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-8876789 "CARNMT1 methylates CARN to Anserine" xref: RHEA:14205 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030736 name: phenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14809] synonym: "PMT" RELATED [EC:2.1.1.25] synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25] xref: EC:2.1.1.25 xref: KEGG_REACTION:R01239 xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14809 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030737 name: iodophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14313] synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26] xref: EC:2.1.1.26 xref: KEGG_REACTION:R03746 xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14313 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030738 name: tyramine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14865] synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27] xref: EC:2.1.1.27 xref: KEGG_REACTION:R02384 xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN xref: RHEA:14865 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030739 name: O-demethylpuromycin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38] synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38] xref: EC:2.1.1.38 xref: MetaCyc:2.1.1.38-RXN xref: RHEA:22280 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030740 name: inositol 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18877] synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39] xref: EC:2.1.1.39 xref: KEGG_REACTION:R01189 xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN xref: RHEA:18877 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030741 name: inositol 1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17565] synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40] synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] xref: EC:2.1.1.40 xref: KEGG_REACTION:R01188 xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN xref: RHEA:17565 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030742 name: GTP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc] comment: This term may be used to annotate both partners in a GTP-dependent binding interaction, both the GTP-bound protein and the protein(s) which interact with it. is_a: GO:0005515 ! protein binding [Term] id: GO:0030743 name: rRNA (adenosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.230] synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.230] synonym: "RNA-pentose methylase activity" RELATED [] synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.230] synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.230] synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.230] xref: EC:2.1.1.230 xref: MetaCyc:2.1.1.66-RXN xref: RHEA:43212 is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity [Term] id: GO:0030744 name: luteolin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14589] synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] xref: EC:2.1.1.42 xref: KEGG_REACTION:R03587 xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN xref: RHEA:14589 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030745 name: dimethylhistidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44] synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] xref: EC:2.1.1.44 xref: KEGG_REACTION:R04436 xref: MetaCyc:2.1.1.44-RXN xref: RHEA:11104 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030746 name: isoflavone 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] xref: EC:2.1.1.46 xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030747 name: indolepyruvate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] xref: EC:2.1.1.47 xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN xref: RHEA:12112 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030748 name: amine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49] synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] xref: EC:2.1.1.49 xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030749 name: loganate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50] xref: EC:2.1.1.50 xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN xref: RHEA:12508 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030750 name: putrescine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15037] synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53] synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53] xref: EC:2.1.1.53 xref: KEGG_REACTION:R01153 xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN xref: RHEA:15037 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030751 name: licodione 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18521] synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65] xref: EC:2.1.1.65 xref: KEGG_REACTION:R03623 xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN xref: RHEA:18521 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030752 name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030764 def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "BMT activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] xref: EC:2.1.1.69 xref: MetaCyc:2.1.1.69-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030753 name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030765 def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70] synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol O-methyltransferase activity" EXACT [] synonym: "XMT activity" RELATED [EC:2.1.1.70] xref: EC:2.1.1.70 xref: KEGG_REACTION:R02982 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030754 name: apigenin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75] synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75] xref: EC:2.1.1.75 xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN xref: RHEA:20429 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030755 name: quercetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76] synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76] xref: EC:2.1.1.76 xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN xref: RHEA:17673 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030756 name: isoorientin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24096] synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78] synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78] xref: EC:2.1.1.78 xref: KEGG_REACTION:R03731 xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN xref: RHEA:24096 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030757 name: 3-methylquercitin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16181] synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "7-OMT activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] xref: EC:2.1.1.82 xref: KEGG_REACTION:R05323 xref: MetaCyc:2.1.1.82-RXN xref: RHEA:16181 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030758 name: 3,7-dimethylquercitin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21832] synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] xref: EC:2.1.1.83 xref: KEGG_REACTION:R03456 xref: MetaCyc:2.1.1.83-RXN xref: RHEA:21832 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030759 name: methylquercetagetin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18717] synonym: "6-OMT" RELATED [EC:2.1.1.84] synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84] synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84] xref: EC:2.1.1.84 xref: KEGG_REACTION:R04505 xref: MetaCyc:2.1.1.84-RXN xref: RHEA:18717 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030760 name: pyridine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16893] synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87] synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87] xref: EC:2.1.1.87 xref: KEGG_REACTION:R02862 xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175987 "NNMT transfers CH3 from AdoMet to PY" xref: RHEA:16893 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030761 name: 8-hydroxyquercitin 8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16593] synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] xref: EC:2.1.1.88 xref: KEGG_REACTION:R04398 xref: MetaCyc:2.1.1.88-RXN xref: RHEA:16593 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030762 name: tetrahydrocolumbamine 2-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22536] synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89] synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89] xref: EC:2.1.1.89 xref: KEGG_REACTION:R04077 xref: MetaCyc:2.1.1.89-RXN xref: RHEA:22536 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030763 name: isobutyraldoxime O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10996] synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] xref: EC:2.1.1.91 xref: KEGG_REACTION:R04169 xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN xref: RHEA:10996 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030766 name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] xref: EC:2.1.1.94 xref: MetaCyc:2.1.1.94-RXN xref: RHEA:20992 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030767 name: 3-hydroxyanthranilate 4-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17833] synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97] synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97] xref: EC:2.1.1.97 xref: KEGG_REACTION:R02667 xref: MetaCyc:2.1.1.97-RXN xref: RHEA:17833 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030768 name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11336] synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "NMT activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] xref: EC:2.1.1.99 xref: KEGG_REACTION:R04013 xref: MetaCyc:2.1.1.99-RXN xref: RHEA:11336 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030769 name: macrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17269] synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101] xref: EC:2.1.1.101 xref: KEGG_REACTION:R02858 xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17269 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030770 name: demethylmacrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17573] synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102] synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102] xref: EC:2.1.1.102 xref: KEGG_REACTION:R02859 xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17573 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030771 name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17405] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105] synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105] xref: EC:2.1.1.105 xref: KEGG_REACTION:R04421 xref: MetaCyc:2.1.1.105-RXN xref: RHEA:17405 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030772 name: tryptophan 2-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17321] synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] xref: EC:2.1.1.106 xref: KEGG_REACTION:R08547 xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN xref: RHEA:17321 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030773 name: 6-hydroxymellein O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15201] synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108] synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108] xref: EC:2.1.1.108 xref: KEGG_REACTION:R03934 xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN xref: RHEA:15201 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030774 name: anthranilate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12180] synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111] synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111] xref: EC:2.1.1.111 xref: KEGG_REACTION:R00984 xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN xref: RHEA:12180 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030775 name: glucuronoxylan 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] xref: EC:2.1.1.112 xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030776 name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] xref: EC:2.1.1.115 xref: MetaCyc:2.1.1.115-RXN xref: RHEA:13005 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030777 name: (S)-scoulerine 9-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23808] synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] xref: EC:2.1.1.117 xref: KEGG_REACTION:R03835 xref: MetaCyc:2.1.1.117-RXN xref: RHEA:23808 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030778 name: columbamine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15373] synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118] xref: EC:2.1.1.118 xref: KEGG_REACTION:R03721 xref: MetaCyc:2.1.1.118-RXN xref: RHEA:15373 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030779 name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18541] synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119] xref: EC:2.1.1.119 xref: KEGG_REACTION:R04707 xref: MetaCyc:2.1.1.119-RXN xref: RHEA:18541 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030780 name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21092] synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120] xref: EC:2.1.1.120 xref: KEGG_REACTION:R04705 xref: MetaCyc:2.1.1.120-RXN xref: RHEA:21092 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030781 name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121] xref: EC:2.1.1.121 xref: MetaCyc:2.1.1.121-RXN xref: RHEA:11892 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030782 name: (S)-tetrahydroprotoberberine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] xref: EC:2.1.1.122 xref: MetaCyc:2.1.1.122-RXN xref: RHEA:12805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030783 name: [cytochrome c]-methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] xref: EC:2.1.1.123 xref: MetaCyc:2.1.1.123-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030784 name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116] xref: EC:2.1.1.116 xref: MetaCyc:2.1.1.116-RXN xref: RHEA:17789 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030785 name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] xref: EC:2.1.1.127 xref: MetaCyc:2.1.1.127-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030786 name: (RS)-norcoclaurine 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128] xref: EC:2.1.1.128 xref: MetaCyc:2.1.1.128-RXN xref: RHEA:19941 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030787 name: inositol 4-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23248] synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] xref: EC:2.1.1.129 xref: KEGG_REACTION:R01190 xref: MetaCyc:2.1.1.129-RXN xref: RHEA:23248 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030788 name: precorrin-2 C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16841] synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130] synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130] xref: EC:2.1.1.130 xref: KEGG_REACTION:R03948 xref: MetaCyc:2.1.1.130-RXN xref: RHEA:16841 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030789 name: precorrin-3B C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] synonym: "CobJ" RELATED [EC:2.1.1.131] synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131] synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131] synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131] xref: EC:2.1.1.131 xref: MetaCyc:2.1.1.131-RXN xref: RHEA:12761 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030790 name: chlorophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] xref: EC:2.1.1.136 xref: MetaCyc:2.1.1.136-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030791 name: arsenite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137] xref: EC:2.1.1.137 xref: MetaCyc:2.1.1.137-RXN xref: Reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite" xref: Reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)" xref: UM-BBD_reactionID:r0805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030792 name: methylarsonite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). xref: EC:2.1.1 xref: MetaCyc:2.1.1.138-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030793 name: 3'-demethylstaurosporine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11696] synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139] xref: EC:2.1.1.139 xref: KEGG_REACTION:R05757 xref: MetaCyc:2.1.1.139-RXN xref: RHEA:11696 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030794 name: (S)-coclaurine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140] xref: EC:2.1.1.140 xref: MetaCyc:2.1.1.140-RXN xref: RHEA:17409 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030795 name: jasmonate O-methyltransferase activity namespace: molecular_function alt_id: GO:0045546 def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141] synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.141 xref: MetaCyc:RXN1F-28 xref: RHEA:13349 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030796 name: cycloartenol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13137] synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142] synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] xref: EC:2.1.1.142 xref: KEGG_REACTION:R05760 xref: MetaCyc:2.1.1.142-RXN xref: RHEA:13137 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030797 name: 24-methylenesterol C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21044] synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] synonym: "SMT2" RELATED [EC:2.1.1.143] xref: EC:2.1.1.143 xref: KEGG_REACTION:R05776 xref: MetaCyc:2.1.1.143-RXN xref: RHEA:21044 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030798 name: trans-aconitate 2-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14969] synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144] xref: EC:2.1.1.144 xref: KEGG_REACTION:R05763 xref: MetaCyc:RXN0-2441 xref: RHEA:14969 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030799 name: obsolete regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cyclic nucleotide metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030800 name: obsolete negative regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide metabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide metabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030801 name: obsolete positive regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide metabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide metabolism" EXACT [] synonym: "stimulation of cyclic nucleotide metabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030802 name: obsolete regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cyclic nucleotide anabolism" EXACT [] synonym: "regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "regulation of cyclic nucleotide formation" EXACT [] synonym: "regulation of cyclic nucleotide synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030803 name: obsolete negative regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of cyclic nucleotide anabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "negative regulation of cyclic nucleotide formation" EXACT [] synonym: "negative regulation of cyclic nucleotide synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030804 name: obsolete positive regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of cyclic nucleotide anabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "positive regulation of cyclic nucleotide formation" EXACT [] synonym: "positive regulation of cyclic nucleotide synthesis" EXACT [] synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030805 name: regulation of cyclic nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] synonym: "regulation of cyclic nucleotide breakdown" EXACT [] synonym: "regulation of cyclic nucleotide catabolism" EXACT [] synonym: "regulation of cyclic nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009214 ! cyclic nucleotide catabolic process relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process [Term] id: GO:0030806 name: obsolete negative regulation of cyclic nucleotide catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide catabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide catabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide breakdown" EXACT [] synonym: "negative regulation of cyclic nucleotide catabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide degradation" EXACT [] is_obsolete: true [Term] id: GO:0030807 name: obsolete positive regulation of cyclic nucleotide catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide catabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide breakdown" EXACT [] synonym: "positive regulation of cyclic nucleotide catabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide degradation" EXACT [] synonym: "stimulation of cyclic nucleotide catabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide catabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030808 name: regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "regulation of nucleotide anabolism" EXACT [] synonym: "regulation of nucleotide biosynthesis" EXACT [] synonym: "regulation of nucleotide formation" EXACT [] synonym: "regulation of nucleotide synthesis" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009165 ! nucleotide biosynthetic process relationship: regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030809 name: negative regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] synonym: "downregulation of nucleotide biosynthetic process" EXACT [] synonym: "inhibition of nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of nucleotide anabolism" EXACT [] synonym: "negative regulation of nucleotide biosynthesis" EXACT [] synonym: "negative regulation of nucleotide formation" EXACT [] synonym: "negative regulation of nucleotide synthesis" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009165 ! nucleotide biosynthetic process relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030810 name: positive regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "activation of nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of nucleotide anabolism" EXACT [] synonym: "positive regulation of nucleotide biosynthesis" EXACT [] synonym: "positive regulation of nucleotide formation" EXACT [] synonym: "positive regulation of nucleotide synthesis" EXACT [] synonym: "stimulation of nucleotide biosynthetic process" NARROW [] synonym: "up regulation of nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] synonym: "upregulation of nucleotide biosynthetic process" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009165 ! nucleotide biosynthetic process relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030811 name: regulation of nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "regulation of nucleotide breakdown" EXACT [] synonym: "regulation of nucleotide catabolism" EXACT [] synonym: "regulation of nucleotide degradation" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009166 ! nucleotide catabolic process relationship: regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030812 name: negative regulation of nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide catabolic process" EXACT [] synonym: "down-regulation of nucleotide catabolic process" EXACT [] synonym: "downregulation of nucleotide catabolic process" EXACT [] synonym: "inhibition of nucleotide catabolic process" NARROW [] synonym: "negative regulation of nucleotide breakdown" EXACT [] synonym: "negative regulation of nucleotide catabolism" EXACT [] synonym: "negative regulation of nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009166 ! nucleotide catabolic process relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030813 name: positive regulation of nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "activation of nucleotide catabolic process" NARROW [] synonym: "positive regulation of nucleotide breakdown" EXACT [] synonym: "positive regulation of nucleotide catabolism" EXACT [] synonym: "positive regulation of nucleotide degradation" EXACT [] synonym: "stimulation of nucleotide catabolic process" NARROW [] synonym: "up regulation of nucleotide catabolic process" EXACT [] synonym: "up-regulation of nucleotide catabolic process" EXACT [] synonym: "upregulation of nucleotide catabolic process" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009166 ! nucleotide catabolic process relationship: positively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030814 name: obsolete regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "regulation of 3',5' cAMP metabolism" EXACT [] synonym: "regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "regulation of cAMP metabolism" EXACT [] synonym: "regulation of cyclic AMP metabolic process" EXACT [] synonym: "regulation of cyclic AMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030815 name: obsolete negative regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cAMP metabolic process" EXACT [] synonym: "down-regulation of cAMP metabolic process" EXACT [] synonym: "downregulation of cAMP metabolic process" EXACT [] synonym: "inhibition of cAMP metabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP metabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "negative regulation of cAMP metabolism" EXACT [] synonym: "negative regulation of cyclic AMP metabolic process" EXACT [] synonym: "negative regulation of cyclic AMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030816 name: obsolete positive regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cAMP metabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP metabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "positive regulation of cAMP metabolism" EXACT [] synonym: "positive regulation of cyclic AMP metabolic process" EXACT [] synonym: "positive regulation of cyclic AMP metabolism" EXACT [] synonym: "stimulation of cAMP metabolic process" NARROW [] synonym: "up regulation of cAMP metabolic process" EXACT [] synonym: "up-regulation of cAMP metabolic process" EXACT [] synonym: "upregulation of cAMP metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030817 name: obsolete regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that the term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "regulation of cAMP anabolism" EXACT [] synonym: "regulation of cAMP biosynthesis" EXACT [] synonym: "regulation of cAMP formation" EXACT [] synonym: "regulation of cAMP synthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030818 name: obsolete negative regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that the term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "down regulation of cAMP biosynthetic process" EXACT [] synonym: "down-regulation of cAMP biosynthetic process" EXACT [] synonym: "downregulation of cAMP biosynthetic process" EXACT [] synonym: "inhibition of cAMP biosynthetic process" NARROW [] synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "negative regulation of cAMP anabolism" EXACT [] synonym: "negative regulation of cAMP biosynthesis" EXACT [] synonym: "negative regulation of cAMP formation" EXACT [] synonym: "negative regulation of cAMP synthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030819 name: obsolete positive regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "activation of cAMP biosynthetic process" NARROW [] synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "positive regulation of cAMP anabolism" EXACT [] synonym: "positive regulation of cAMP biosynthesis" EXACT [] synonym: "positive regulation of cAMP formation" EXACT [] synonym: "positive regulation of cAMP synthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT [] synonym: "stimulation of cAMP biosynthetic process" NARROW [] synonym: "up regulation of cAMP biosynthetic process" EXACT [] synonym: "up-regulation of cAMP biosynthetic process" EXACT [] synonym: "upregulation of cAMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030820 name: obsolete regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "regulation of 3',5' cAMP catabolism" EXACT [] synonym: "regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "regulation of cAMP breakdown" EXACT [] synonym: "regulation of cAMP catabolism" EXACT [] synonym: "regulation of cAMP degradation" EXACT [] synonym: "regulation of cyclic AMP catabolic process" EXACT [] synonym: "regulation of cyclic AMP catabolism" EXACT [] is_obsolete: true [Term] id: GO:0030821 name: obsolete negative regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cAMP catabolic process" EXACT [] synonym: "down-regulation of cAMP catabolic process" EXACT [] synonym: "downregulation of cAMP catabolic process" EXACT [] synonym: "inhibition of cAMP catabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP catabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "negative regulation of cAMP breakdown" EXACT [] synonym: "negative regulation of cAMP catabolism" EXACT [] synonym: "negative regulation of cAMP degradation" EXACT [] synonym: "negative regulation of cyclic AMP catabolic process" EXACT [] synonym: "negative regulation of cyclic AMP catabolism" EXACT [] is_obsolete: true [Term] id: GO:0030822 name: obsolete positive regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cAMP catabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP catabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "positive regulation of cAMP breakdown" EXACT [] synonym: "positive regulation of cAMP catabolism" EXACT [] synonym: "positive regulation of cAMP degradation" EXACT [] synonym: "positive regulation of cyclic AMP catabolic process" EXACT [] synonym: "positive regulation of cyclic AMP catabolism" EXACT [] synonym: "stimulation of cAMP catabolic process" NARROW [] synonym: "up regulation of cAMP catabolic process" EXACT [] synonym: "up-regulation of cAMP catabolic process" EXACT [] synonym: "upregulation of cAMP catabolic process" EXACT [] is_obsolete: true consider: GO:0071878 [Term] id: GO:0030823 name: obsolete regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030824 name: obsolete negative regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP metabolic process" EXACT [] synonym: "down-regulation of cGMP metabolic process" EXACT [] synonym: "downregulation of cGMP metabolic process" EXACT [] synonym: "inhibition of cGMP metabolic process" NARROW [] synonym: "negative regulation of cGMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030825 name: obsolete positive regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP metabolic process" NARROW [] synonym: "positive regulation of cGMP metabolism" EXACT [] synonym: "stimulation of cGMP metabolic process" NARROW [] synonym: "up regulation of cGMP metabolic process" EXACT [] synonym: "up-regulation of cGMP metabolic process" EXACT [] synonym: "upregulation of cGMP metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030826 name: obsolete regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP anabolism" EXACT [] synonym: "regulation of cGMP biosynthesis" EXACT [] synonym: "regulation of cGMP formation" EXACT [] synonym: "regulation of cGMP synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030827 name: obsolete negative regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP biosynthetic process" EXACT [] synonym: "down-regulation of cGMP biosynthetic process" EXACT [] synonym: "downregulation of cGMP biosynthetic process" EXACT [] synonym: "inhibition of cGMP biosynthetic process" NARROW [] synonym: "negative regulation of cGMP anabolism" EXACT [] synonym: "negative regulation of cGMP biosynthesis" EXACT [] synonym: "negative regulation of cGMP formation" EXACT [] synonym: "negative regulation of cGMP synthesis" EXACT [] is_obsolete: true consider: GO:0030251 [Term] id: GO:0030828 name: obsolete positive regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP biosynthetic process" NARROW [] synonym: "positive regulation of cGMP anabolism" EXACT [] synonym: "positive regulation of cGMP biosynthesis" EXACT [] synonym: "positive regulation of cGMP formation" EXACT [] synonym: "positive regulation of cGMP synthesis" EXACT [] synonym: "stimulation of cGMP biosynthetic process" NARROW [] synonym: "up regulation of cGMP biosynthetic process" EXACT [] synonym: "up-regulation of cGMP biosynthetic process" EXACT [] synonym: "upregulation of cGMP biosynthetic process" EXACT [] is_obsolete: true consider: GO:0004383 [Term] id: GO:0030829 name: obsolete regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP breakdown" EXACT [] synonym: "regulation of cGMP catabolism" EXACT [] synonym: "regulation of cGMP degradation" EXACT [] is_obsolete: true [Term] id: GO:0030830 name: obsolete negative regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP catabolic process" EXACT [] synonym: "down-regulation of cGMP catabolic process" EXACT [] synonym: "downregulation of cGMP catabolic process" EXACT [] synonym: "inhibition of cGMP catabolic process" NARROW [] synonym: "negative regulation of cGMP breakdown" EXACT [] synonym: "negative regulation of cGMP catabolism" EXACT [] synonym: "negative regulation of cGMP degradation" EXACT [] is_obsolete: true [Term] id: GO:0030831 name: obsolete positive regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP catabolic process" NARROW [] synonym: "positive regulation of cGMP breakdown" EXACT [] synonym: "positive regulation of cGMP catabolism" EXACT [] synonym: "positive regulation of cGMP degradation" EXACT [] synonym: "stimulation of cGMP catabolic process" NARROW [] synonym: "up regulation of cGMP catabolic process" EXACT [] synonym: "up-regulation of cGMP catabolic process" EXACT [] synonym: "upregulation of cGMP catabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030832 name: regulation of actin filament length namespace: biological_process def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0032535 ! regulation of cellular component size is_a: GO:0032956 ! regulation of actin cytoskeleton organization [Term] id: GO:0030833 name: regulation of actin filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "regulation of actin polymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030041 ! actin filament polymerization relationship: regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030834 name: regulation of actin filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "regulation of actin depolymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030042 ! actin filament depolymerization relationship: regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030835 name: negative regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030044 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). synonym: "actin filament stabilization" EXACT [] synonym: "down regulation of actin filament depolymerization" EXACT [] synonym: "down-regulation of actin filament depolymerization" EXACT [] synonym: "downregulation of actin filament depolymerization" EXACT [] synonym: "inhibition of actin filament depolymerization" NARROW [] synonym: "negative regulation of actin depolymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030042 ! actin filament depolymerization relationship: negatively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030836 name: positive regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030045 def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). synonym: "actin filament destabilization" EXACT [] synonym: "activation of actin filament depolymerization" NARROW [] synonym: "positive regulation of actin depolymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament depolymerization" NARROW [] synonym: "up regulation of actin filament depolymerization" EXACT [] synonym: "up-regulation of actin filament depolymerization" EXACT [] synonym: "upregulation of actin filament depolymerization" EXACT [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030042 ! actin filament depolymerization relationship: positively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030837 name: negative regulation of actin filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). synonym: "down regulation of actin filament polymerization" EXACT [] synonym: "down-regulation of actin filament polymerization" EXACT [] synonym: "downregulation of actin filament polymerization" EXACT [] synonym: "inhibition of actin filament polymerization" NARROW [] synonym: "negative regulation of actin polymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030041 ! actin filament polymerization relationship: negatively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030838 name: positive regulation of actin filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). synonym: "activation of actin filament polymerization" NARROW [] synonym: "positive regulation of actin polymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament polymerization" NARROW [] synonym: "up regulation of actin filament polymerization" EXACT [] synonym: "up-regulation of actin filament polymerization" EXACT [] synonym: "upregulation of actin filament polymerization" EXACT [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030041 ! actin filament polymerization relationship: positively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030839 name: regulation of intermediate filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah] is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045107 ! intermediate filament polymerization relationship: regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030840 name: negative regulation of intermediate filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). synonym: "down regulation of intermediate filament polymerization" EXACT [] synonym: "down-regulation of intermediate filament polymerization" EXACT [] synonym: "downregulation of intermediate filament polymerization" EXACT [] synonym: "inhibition of intermediate filament polymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045107 ! intermediate filament polymerization relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030841 name: positive regulation of intermediate filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). synonym: "activation of intermediate filament polymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament polymerization" NARROW [] synonym: "up regulation of intermediate filament polymerization" EXACT [] synonym: "up-regulation of intermediate filament polymerization" EXACT [] synonym: "upregulation of intermediate filament polymerization" EXACT [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045107 ! intermediate filament polymerization relationship: positively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030842 name: regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah] is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045106 ! intermediate filament depolymerization relationship: regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030843 name: negative regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). synonym: "down regulation of intermediate filament depolymerization" EXACT [] synonym: "down-regulation of intermediate filament depolymerization" EXACT [] synonym: "downregulation of intermediate filament depolymerization" EXACT [] synonym: "inhibition of intermediate filament depolymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1901880 ! negative regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045106 ! intermediate filament depolymerization relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030844 name: positive regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). synonym: "activation of intermediate filament depolymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament depolymerization" NARROW [] synonym: "up regulation of intermediate filament depolymerization" EXACT [] synonym: "up-regulation of intermediate filament depolymerization" EXACT [] synonym: "upregulation of intermediate filament depolymerization" EXACT [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1901881 ! positive regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045106 ! intermediate filament depolymerization relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030845 name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition. synonym: "G-protein-coupled inhibitory pathway of phospholipase C" EXACT [PMID:8280098] synonym: "GPCR signaling pathway coupled to inhibition of phospholipase C activity" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via inhibition of PLC" EXACT [GOC:signaling] synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "phospholipase C inhibition" RELATED [GOC:dph, GOC:tb] synonym: "phospholipase C-inhibiting G-protein coupled receptor signaling pathway" EXACT [] synonym: "PLC-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: has_part GO:1900275 ! negative regulation of phospholipase C activity [Term] id: GO:0030846 name: termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030847 name: termination of RNA polymerase II transcription, exosome-dependent namespace: biological_process def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030848 name: threo-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12424] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] xref: EC:4.3.1.16 xref: KEGG_REACTION:R05758 xref: MetaCyc:4.3.1.16-RXN xref: RHEA:12424 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0030849 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: Wikipedia:Autosome is_a: GO:0005694 ! chromosome [Term] id: GO:0030850 name: prostate gland development namespace: biological_process def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] synonym: "prostate development" EXACT [] xref: MIPS_funcat:47.03.15.09 is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development relationship: part_of GO:0001655 ! urogenital system development [Term] id: GO:0030851 name: granulocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] synonym: "granulocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030852 name: regulation of granulocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030851 ! granulocyte differentiation relationship: regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030853 name: negative regulation of granulocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "down regulation of granulocyte differentiation" EXACT [] synonym: "down-regulation of granulocyte differentiation" EXACT [] synonym: "downregulation of granulocyte differentiation" EXACT [] synonym: "inhibition of granulocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030851 ! granulocyte differentiation relationship: negatively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030854 name: positive regulation of granulocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "activation of granulocyte differentiation" NARROW [] synonym: "stimulation of granulocyte differentiation" NARROW [] synonym: "up regulation of granulocyte differentiation" EXACT [] synonym: "up-regulation of granulocyte differentiation" EXACT [] synonym: "upregulation of granulocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030851 ! granulocyte differentiation relationship: positively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030855 ! epithelial cell differentiation relationship: regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030855 ! epithelial cell differentiation relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030855 ! epithelial cell differentiation relationship: positively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030859 name: polarized epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0030860 name: regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030859 ! polarized epithelial cell differentiation relationship: regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030861 name: negative regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "down regulation of polarized epithelial cell differentiation" EXACT [] synonym: "down-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "downregulation of polarized epithelial cell differentiation" EXACT [] synonym: "inhibition of polarized epithelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030862 name: positive regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "activation of polarized epithelial cell differentiation" NARROW [] synonym: "stimulation of polarized epithelial cell differentiation" NARROW [] synonym: "up regulation of polarized epithelial cell differentiation" EXACT [] synonym: "up-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "upregulation of polarized epithelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030859 ! polarized epithelial cell differentiation relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030863 name: cortical cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0005856 ! cytoskeleton relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0030864 name: cortical actin cytoskeleton namespace: cellular_component def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton intersection_of: GO:0030863 ! cortical cytoskeleton intersection_of: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0030865 name: cortical cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical cytoskeleton organisation" EXACT [] synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0030866 name: cortical actin cytoskeleton organization namespace: biological_process alt_id: GO:0033109 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf] synonym: "actin cortex stabilization" EXACT [] synonym: "cortical actin cytoskeleton organisation" EXACT [] synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "cortical actin cytoskeleton stabilization" EXACT [] synonym: "cortical resistance" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030865 ! cortical cytoskeleton organization [Term] id: GO:0030867 name: rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] synonym: "RER membrane" EXACT [NIF_Subcellular:sao3089754107] synonym: "rough ER membrane" EXACT [] xref: NIF_Subcellular:sao3089754107 is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0030868 name: smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] synonym: "SER membrane" EXACT [] synonym: "smooth ER membrane" EXACT [] xref: NIF_Subcellular:sao1596955044 is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0030869 name: RENT complex namespace: cellular_component def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] is_a: GO:0005677 ! chromatin silencing complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0030870 name: Mre11 complex namespace: cellular_component def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] synonym: "MRN complex" EXACT [] synonym: "MRX complex" EXACT [] synonym: "Rad50 complex" EXACT [] synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767] synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] synonym: "RMX complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0030874 name: nucleolar chromatin namespace: cellular_component def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000790 ! nuclear chromatin relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0030875 name: rDNA protrusion namespace: cellular_component def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. synonym: "ribosomal DNA protrusion" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030874 ! nucleolar chromatin [Term] id: GO:0030876 name: interleukin-20 receptor complex namespace: cellular_component def: "A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits." [PMID:12351624] synonym: "IL-20 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030877 name: beta-catenin destruction complex namespace: cellular_component alt_id: GO:0034742 alt_id: GO:0034747 def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "23S APC complex" NARROW [] synonym: "APC-Axin-1-beta-catenin complex" EXACT [] synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT [] synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650] synonym: "beta-catenin degradation complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0030878 name: thyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] xref: MIPS_funcat:47.03.21.03.06 is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030879 name: mammary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] synonym: "mammogenesis" NARROW [GOC:dph] xref: MIPS_funcat:47.03.21.01 is_a: GO:0048732 ! gland development [Term] id: GO:0030880 name: RNA polymerase complex namespace: cellular_component def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] subset: goslim_pir synonym: "multisubunit RNA polymerase" EXACT [] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030881 name: beta-2-microglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0030882 name: lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461] is_a: GO:0003823 ! antigen binding is_a: GO:0008289 ! lipid binding [Term] id: GO:0030883 name: endogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030884 name: exogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030885 name: regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001773 ! myeloid dendritic cell activation relationship: regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030886 name: negative regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] synonym: "down regulation of myeloid dendritic cell activation" EXACT [] synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] synonym: "downregulation of myeloid dendritic cell activation" EXACT [] synonym: "inhibition of myeloid dendritic cell activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001773 ! myeloid dendritic cell activation relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030887 name: positive regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] synonym: "activation of myeloid dendritic cell activation" NARROW [] synonym: "stimulation of myeloid dendritic cell activation" NARROW [] synonym: "up regulation of myeloid dendritic cell activation" EXACT [] synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] synonym: "upregulation of myeloid dendritic cell activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001773 ! myeloid dendritic cell activation relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030888 name: regulation of B cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] synonym: "regulation of B lymphocyte proliferation" EXACT [] synonym: "regulation of B-cell proliferation" EXACT [] synonym: "regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050864 ! regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042100 ! B cell proliferation relationship: regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030889 name: negative regulation of B cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] synonym: "down regulation of B cell proliferation" EXACT [] synonym: "down-regulation of B cell proliferation" EXACT [] synonym: "downregulation of B cell proliferation" EXACT [] synonym: "inhibition of B cell proliferation" NARROW [] synonym: "negative regulation of B lymphocyte proliferation" EXACT [] synonym: "negative regulation of B-cell proliferation" EXACT [] synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050869 ! negative regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042100 ! B cell proliferation relationship: negatively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030890 name: positive regulation of B cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] synonym: "activation of B cell proliferation" NARROW [] synonym: "positive regulation of B lymphocyte proliferation" EXACT [] synonym: "positive regulation of B-cell proliferation" EXACT [] synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] synonym: "stimulation of B cell proliferation" NARROW [] synonym: "up regulation of B cell proliferation" EXACT [] synonym: "up-regulation of B cell proliferation" EXACT [] synonym: "upregulation of B cell proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050871 ! positive regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042100 ! B cell proliferation relationship: positively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030891 name: VCB complex namespace: cellular_component def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] synonym: "pVHL-elongin C-elongin B complex" EXACT [] synonym: "VHL complex" EXACT [] synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex [Term] id: GO:0030892 name: mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030893 name: meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030894 name: replisome namespace: cellular_component def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] subset: goslim_pir synonym: "DNA synthesome complex" RELATED [CORUM:1001] synonym: "RC complex" RELATED [CORUM:309, PMID:12006500] synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500] xref: Wikipedia:Replisome is_a: GO:0032993 ! protein-DNA complex relationship: has_part GO:0033202 ! DNA helicase complex relationship: has_part GO:0042575 ! DNA polymerase complex relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0030895 name: apolipoprotein B mRNA editing enzyme complex namespace: cellular_component def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] synonym: "apoB mRNA editing enzyme complex" EXACT [] synonym: "APOBEC" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0030896 name: checkpoint clamp complex namespace: cellular_component def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. synonym: "CCC" EXACT [] synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0030897 name: HOPS complex namespace: cellular_component def: "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] is_a: GO:0098796 ! membrane protein complex is_a: GO:0099023 ! vesicle tethering complex [Term] id: GO:0030898 name: actin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] synonym: "actin-activated ATPase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030899 name: calcium-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030900 name: forebrain development namespace: biological_process def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] synonym: "prosencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0030904 name: retromer complex namespace: cellular_component def: "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157] subset: goslim_pir is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030905 name: retromer, tubulation complex namespace: cellular_component def: "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157] synonym: "heterodimeric membrane-deforming retromer subcomplex" EXACT [GOC:bf, GOC:PARL, PMID:22193161] synonym: "retromer complex, outer shell" EXACT [] synonym: "SNX-BAR dimer" EXACT [PMID:26220253] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030906 name: retromer, cargo-selective complex namespace: cellular_component def: "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157] synonym: "cargo-selective retromer subcomplex" EXACT [PMID:19531583, PMID:20923837] synonym: "retromer complex, inner shell" EXACT [] synonym: "retromer CSC" EXACT [GOC:bf, GOC:PARL] synonym: "retromer, cargo recognition complex" EXACT [PMID:26220253] synonym: "retromer, CRC" EXACT [GOC:bf, GOC:PARL, PMID:26220253] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030907 name: MBF transcription complex namespace: cellular_component def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385] synonym: "DSC1 transcription factor complex" EXACT [] synonym: "MBF" EXACT [] synonym: "Mlu1-box binding factor" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0030908 name: protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah] xref: Wikipedia:Protein_splicing is_a: GO:0016485 ! protein processing [Term] id: GO:0030909 name: non-intein-mediated protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah] is_a: GO:0030908 ! protein splicing [Term] id: GO:0030910 name: olfactory placode formation namespace: biological_process def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0043584 ! nose development relationship: part_of GO:0071699 ! olfactory placode morphogenesis [Term] id: GO:0030911 name: TPR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] synonym: "tetratricopeptide repeat domain binding" EXACT [GOC:sl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030912 name: response to deep water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah] comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. is_a: GO:0009415 ! response to water [Term] id: GO:0030913 name: paranodal junction assembly namespace: biological_process def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942] synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321] synonym: "paranodal junction biosynthesis" EXACT [] synonym: "paranodal junction formation" EXACT [] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0032288 ! myelin assembly [Term] id: GO:0030914 name: STAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SPT3-TAF9-GCN5 acetylase complex" EXACT [GOC:rl, PMID:18838386] synonym: "STAGA coactivator complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0030915 name: Smc5-Smc6 complex namespace: cellular_component def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152] is_a: GO:0106068 ! SUMO ligase complex relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0030916 name: otic vesicle formation namespace: biological_process def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] synonym: "otocyst biosynthesis" EXACT [] synonym: "otocyst formation" EXACT [] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0071600 ! otic vesicle morphogenesis [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0030919 name: peptidyl-serine O-acetylation namespace: biological_process def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364] xref: RESID:AA0364 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0030920 name: peptidyl-serine acetylation namespace: biological_process def: "The acetylation of peptidyl-serine." [GOC:mah] is_a: GO:0006473 ! protein acetylation [Term] id: GO:0030921 name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183] xref: RESID:AA0183 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030922 name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365] xref: RESID:AA0365 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030923 name: metal incorporation into metallo-oxygen cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0030924 name: manganese incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg] is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030925 name: calcium incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg] is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030926 name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] xref: RESID:AA0366 is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster [Term] id: GO:0030927 name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] xref: RESID:AA0366 is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster [Term] id: GO:0030929 name: ADPG pyrophosphorylase complex namespace: cellular_component def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0030930 name: homotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030931 name: heterotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030932 name: amyloplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex intersection_of: part_of GO:0009501 ! amyloplast relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0030933 name: chloroplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009507 ! chloroplast [Term] id: GO:0030934 name: anchoring collagen complex namespace: cellular_component def: "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] synonym: "connecting collagen" EXACT [ISBN:0721639976] synonym: "linking collagen" EXACT [ISBN:0721639976] is_a: GO:0005581 ! collagen trimer relationship: part_of GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0030935 name: sheet-forming collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet." [PMID:7188361] synonym: "hexagonal network-forming collagen" EXACT [ISBN:0815316194] is_a: GO:0098642 ! network-forming collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098646 ! collagen sheet relationship: part_of GO:0098646 ! collagen sheet [Term] id: GO:0030936 name: transmembrane collagen trimer namespace: cellular_component def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030937 name: collagen type XVII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911] is_a: GO:0030936 ! transmembrane collagen trimer is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion is_a: GO:0098733 ! hemidesmosome associated protein complex [Term] id: GO:0030938 name: collagen type XVIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976, PMID:21421911] is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0030939 name: obsolete response to long-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. synonym: "response to long-day photoperiod" EXACT [] is_obsolete: true consider: GO:0048571 [Term] id: GO:0030940 name: obsolete response to short-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. synonym: "response to short-day photoperiod" EXACT [] is_obsolete: true consider: GO:0048572 [Term] id: GO:0030941 name: chloroplast targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030942 name: endoplasmic reticulum signal peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] synonym: "ER signal peptide binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030943 name: mitochondrion targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] synonym: "mitochondrial targeting sequence binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030944 name: DDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0030945 name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate namespace: molecular_function def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030946 name: protein tyrosine phosphatase activity, metal-dependent namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030947 name: regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "regulation of VEGF receptor signaling pathway" EXACT [] synonym: "regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030948 name: negative regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signaling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030949 name: positive regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signaling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signalling pathway" EXACT [] synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030950 name: establishment or maintenance of actin cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030953 name: astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] synonym: "astral microtubule organisation" EXACT [] synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0030954 name: astral microtubule nucleation namespace: biological_process def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah] is_a: GO:0030953 ! astral microtubule organization is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center [Term] id: GO:0030955 name: potassium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] xref: MIPS_funcat:16.17.03 is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0030956 name: glutamyl-tRNA(Gln) amidotransferase complex namespace: cellular_component def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. synonym: "AdT" RELATED [GOC:rb] synonym: "GatCAB" NARROW [GOC:rb] synonym: "GatFAB" NARROW [GOC:rb] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0030957 name: Tat protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0030958 name: RITS complex namespace: cellular_component def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] is_a: GO:0031332 ! RNAi effector complex relationship: part_of GO:0005720 ! nuclear heterochromatin [Term] id: GO:0030959 name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367] xref: RESID:AA0367 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030960 name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368] xref: RESID:AA0368 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030961 name: peptidyl-arginine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah] is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0030962 name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine namespace: biological_process def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369] xref: RESID:AA0369 is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0030963 name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine namespace: biological_process def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370] xref: RESID:AA0370 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0030964 name: NADH dehydrogenase complex namespace: cellular_component alt_id: GO:0030025 alt_id: GO:0030966 alt_id: GO:0031675 alt_id: GO:0031677 alt_id: GO:0031678 alt_id: GO:0045280 def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. subset: goslim_pir synonym: "Complex I" EXACT [] synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] synonym: "NADH dehydrogenase complex (quinone)" NARROW [] synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW [] synonym: "NADH:plastoquinone reductase complex" NARROW [] synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] xref: Wikipedia:NADH_dehydrogenase is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0030965 name: plasma membrane electron transport, NADH to quinone namespace: biological_process def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport [Term] id: GO:0030968 name: endoplasmic reticulum unfolded protein response namespace: biological_process def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763] comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. synonym: "ER unfolded protein response" EXACT [] synonym: "erUPR" EXACT [] synonym: "SREBP-mediated signalling pathway" RELATED [] xref: MIPS_funcat:32.01.07 is_a: GO:0007165 ! signal transduction is_a: GO:0034976 ! response to endoplasmic reticulum stress relationship: part_of GO:0034620 ! cellular response to unfolded protein [Term] id: GO:0030969 name: obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response namespace: biological_process def: "OBSOLETE. The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241] comment: The reason for obsoletion is that this process represent a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). synonym: "HAC1 mRNA splicing" NARROW [PMID:21924241] synonym: "IRE1-mediated XBP-1 mRNA splicing" NARROW [GOC:bf] synonym: "Ire1p-mediated HAC-1 mRNA splicing" NARROW [GOC:bf] synonym: "non-spliceosomal mRNA splicing in the unfolded protein response pathway" EXACT [PMID:10357823] synonym: "spliceosome-independent UFP-specific transcription factor mRNA processing" EXACT [GOC:dph] synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb] synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in ER unfolded protein response" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in ER UPR" EXACT [GOC:bf] synonym: "unconventional mRNA splicing involved in UPR" EXACT [GOC:bf] synonym: "unconventional splicing of XBP1 mRNA" EXACT [PMID:11779464, PMID:26068456] synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED [] synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED [] synonym: "XBP1 mRNA splicing" EXACT [PMID:11779464, PMID:25968568] synonym: "XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress" NARROW [PMID:21924241] synonym: "XBP1 mRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GOC:bf] is_obsolete: true consider: GO:0036498 [Term] id: GO:0030970 name: retrograde protein transport, ER to cytosol namespace: biological_process def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744] synonym: "protein dislocation from ER" EXACT [GOC:dph, GOC:krc] synonym: "protein retrotranslocation, ER to cytosol" EXACT [GOC:bf] synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [] is_a: GO:0032527 ! protein exit from endoplasmic reticulum is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport relationship: part_of GO:0036503 ! ERAD pathway [Term] id: GO:0030971 name: receptor tyrosine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:1990782 ! protein tyrosine kinase binding [Term] id: GO:0030972 name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "apoptotic cleavage of cytosolic proteins" EXACT [] synonym: "cleavage of cytosolic proteins involved in apoptosis" BROAD [] synonym: "cleavage of cytosolic proteins involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0030973 name: molybdate ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdate (MoO4 2-) ions." [GOC:mlg] is_a: GO:0043168 ! anion binding [Term] id: GO:0030974 name: thiamine pyrophosphate transmembrane transport namespace: biological_process def: "The process in which thiamine pyrophosphate is transported across a membrane." [GOC:mlg] synonym: "thiamin diphosphate transport" EXACT [] synonym: "thiamin pyrophosphate transport" EXACT [] synonym: "thiamine diphosphate transport" EXACT [] synonym: "thiamine pyrophosphate transport" NARROW [] synonym: "TPP transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072348 ! sulfur compound transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0030975 name: thiamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] synonym: "thiamin binding" EXACT [] synonym: "vitamin B1 binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0030976 name: thiamine pyrophosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg] synonym: "aneurine pyrophosphate binding" EXACT [] synonym: "cocarboxylase binding" EXACT [] synonym: "diphosphothiamin binding" EXACT [] synonym: "thiamin pyrophosphate binding" EXACT [] synonym: "TPP binding" EXACT [] xref: MIPS_funcat:16.21.11 is_a: GO:0019842 ! vitamin binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0030977 name: taurine binding namespace: molecular_function def: "Interacting selectively and non-covalently with taurine." [GOC:mlg] is_a: GO:0043210 ! alkanesulfonate binding [Term] id: GO:0030978 name: alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] synonym: "alpha-glucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0030979 name: alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] synonym: "alpha-glucan anabolism" EXACT [] synonym: "alpha-glucan biosynthesis" EXACT [] synonym: "alpha-glucan formation" EXACT [] synonym: "alpha-glucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0030980 name: alpha-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah] synonym: "alpha-glucan breakdown" EXACT [] synonym: "alpha-glucan catabolism" EXACT [] synonym: "alpha-glucan degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0030978 ! alpha-glucan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030981 name: cortical microtubule cytoskeleton namespace: cellular_component def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0030982 name: adventurous gliding motility namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173] synonym: "adventurous gliding movement" EXACT [] is_a: GO:0071976 ! cell gliding [Term] id: GO:0030983 name: mismatched DNA binding namespace: molecular_function alt_id: GO:0032134 def: "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] synonym: "mispair binding" EXACT [] synonym: "mispaired DNA binding" EXACT [] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0030984 name: kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414] is_a: GO:0005515 ! protein binding [Term] id: GO:0030985 name: high molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414] synonym: "HK binding" EXACT [] synonym: "HMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030986 name: low molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414] synonym: "LK binding" EXACT [] synonym: "LMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030987 name: high molecular weight kininogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030988 name: high molecular weight kininogen receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030989 name: dynein-driven meiotic oscillatory nuclear movement namespace: biological_process def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142] comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination. synonym: "HNM" EXACT [] synonym: "horsetail movement" EXACT [] synonym: "horsetail nuclear movement" EXACT [GOC:vw] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0030991 name: intraciliary transport particle A namespace: cellular_component def: "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. synonym: "IFT A complex" RELATED [] synonym: "IFT complex A" RELATED [] synonym: "intraflagellar transport complex A" EXACT [] synonym: "intraflagellar transport particle A" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030990 ! intraciliary transport particle [Term] id: GO:0030992 name: intraciliary transport particle B namespace: cellular_component def: "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. synonym: "IFT B complex" RELATED [] synonym: "IFT complex B" RELATED [] synonym: "intraflagellar transport complex B" EXACT [] synonym: "intraflagellar transport particle B" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030990 ! intraciliary transport particle [Term] id: GO:0030993 name: axonemal heterotrimeric kinesin-II complex namespace: cellular_component def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005930 ! axoneme [Term] id: GO:0030994 name: primary cell septum disassembly namespace: biological_process def: "Dissolution of the primary septum during cell separation." [PMID:12665550] synonym: "hydrolysis of primary cell septum" EXACT [] synonym: "primary cell septum hydrolysis" EXACT [] synonym: "primary septum hydrolysis" BROAD [] is_a: GO:0022411 ! cellular component disassembly relationship: part_of GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0030995 name: cell septum edging catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814] synonym: "cell septum edging hydrolysis" EXACT [] synonym: "hydrolysis of cell septum edging" EXACT [] synonym: "hydrolysis of edging of cell septum" EXACT [] synonym: "septum edging hydrolysis" BROAD [] is_a: GO:0071999 ! extracellular polysaccharide catabolic process relationship: part_of GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0030996 name: obsolete mitotic cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. synonym: "cell cycle arrest in response to nitrogen starvation" BROAD [] is_obsolete: true [Term] id: GO:0030997 name: regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] is_a: GO:0046605 ! regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010457 ! centriole-centriole cohesion relationship: part_of GO:0007098 ! centrosome cycle relationship: regulates GO:0010457 ! centriole-centriole cohesion [Term] id: GO:0030998 name: linear element namespace: cellular_component def: "A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex." [DOI:10.2323/jgam.28.263, GOC:jb, PMID:12665553, PMID:30640914] is_a: GO:0099086 ! synaptonemal structure [Term] id: GO:0030999 name: linear element assembly namespace: biological_process def: "The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex." [GOC:jb, GOC:mah, PMID:30640914] synonym: "linear element formation" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0031000 name: response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:ef, GOC:mah] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0036270 ! response to diuretic is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0031001 name: response to brefeldin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0031002 name: actin rod namespace: cellular_component def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions." [GOC:kp, GOC:krc, PMID:11858703, PMID:19459188, PMID:22623727, PMID:24813767, PMID:27535426, PMID:7820870] is_a: GO:0032432 ! actin filament bundle [Term] id: GO:0031003 name: actin tubule namespace: cellular_component def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] is_a: GO:0032432 ! actin filament bundle relationship: part_of GO:0031002 ! actin rod [Term] id: GO:0031004 name: potassium ion-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692] synonym: "Kdp system complex" EXACT [] is_a: GO:0090533 ! cation-transporting ATPase complex [Term] id: GO:0031005 name: filamin binding namespace: molecular_function alt_id: GO:0031006 alt_id: GO:0031007 alt_id: GO:0031008 def: "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] synonym: "ABP-278/276 binding" NARROW [] synonym: "ABP-280 binding" NARROW [] synonym: "ABPL binding" NARROW [] synonym: "alpha-filamin binding" NARROW [] synonym: "beta-filamin binding" NARROW [] synonym: "filamin A binding" NARROW [] synonym: "filamin B binding" NARROW [] synonym: "filamin C binding" EXACT [] synonym: "filamin-1 binding" NARROW [] synonym: "filamin-2 binding" NARROW [] synonym: "filamin-3 binding" NARROW [] synonym: "filamin-A binding" NARROW [] synonym: "filamin-B binding" EXACT [] synonym: "filamin-C binding" NARROW [] synonym: "gamma-filamin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031009 name: plastid ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex intersection_of: GO:0030929 ! ADPG pyrophosphorylase complex intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0031010 name: ISWI-type complex namespace: cellular_component def: "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0031011 name: Ino80 complex namespace: cellular_component def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] synonym: "INO80 chromatin remodeling complex" EXACT [] is_a: GO:0033202 ! DNA helicase complex is_a: GO:0097346 ! INO80-type complex [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: MIPS_funcat:70.27.01 xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0031013 name: troponin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031014 name: troponin T binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031015 name: obsolete karyopherin docking complex namespace: cellular_component def: "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] synonym: "Asm4p-containing complex" NARROW [] synonym: "karyopherin docking complex" EXACT [] synonym: "nuclear pore subcomplex" BROAD [] is_obsolete: true consider: GO:0017056 consider: GO:0044613 [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] xref: MIPS_funcat:47.03.11.09 xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development [Term] id: GO:0031017 name: exocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] is_a: GO:0048732 ! gland development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035272 ! exocrine system development relationship: part_of GO:0055123 ! digestive system development [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0031019 name: mitochondrial mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] synonym: "mitochondrial editosome" EXACT [] is_a: GO:0045293 ! mRNA editing complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0045293 ! mRNA editing complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0031020 name: plastid mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in a plastid." [GOC:mah] synonym: "plastid editosome" EXACT [] is_a: GO:0045293 ! mRNA editing complex intersection_of: GO:0045293 ! mRNA editing complex intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0031021 name: interphase microtubule organizing center namespace: cellular_component def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] synonym: "iMTOC" EXACT [] synonym: "interphase microtubule organising center" EXACT [] synonym: "interphase MTOC" EXACT [] is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031024 name: interphase microtubule organizing center assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790] synonym: "interphase microtubule organising center biosynthesis" EXACT [] synonym: "interphase microtubule organising center formation" EXACT [] synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah] synonym: "interphase microtubule organizing centre assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0031025 name: equatorial microtubule organizing center disassembly namespace: biological_process def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790] synonym: "equatorial microtubule organising center disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0031121 ! equatorial microtubule organization [Term] id: GO:0031026 name: glutamate synthase complex namespace: cellular_component def: "A complex that possesses glutamate synthase activity." [GOC:mah] subset: goslim_pir is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031027 name: glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0031028 name: septation initiation signaling namespace: biological_process def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] synonym: "septation initiation network" EXACT [] synonym: "septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "septation initiation signalling" EXACT [] synonym: "SIN" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0007265 ! Ras protein signal transduction is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction is_a: GO:1901893 ! positive regulation of cell septum assembly is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process [Term] id: GO:0031029 name: regulation of septation initiation signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "regulation of septation initiation network" EXACT [] synonym: "regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "regulation of septation initiation signalling" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:1901891 ! regulation of cell septum assembly is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031028 ! septation initiation signaling relationship: regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031030 name: negative regulation of septation initiation signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "down regulation of septation initiation signaling" EXACT [] synonym: "down-regulation of septation initiation signaling" EXACT [] synonym: "downregulation of septation initiation signaling" EXACT [] synonym: "inhibition of septation initiation signaling" NARROW [] synonym: "negative regulation of septation initiation network" EXACT [] synonym: "negative regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of septation initiation signalling" EXACT [] is_a: GO:0010974 ! negative regulation of division septum assembly is_a: GO:0031029 ! regulation of septation initiation signaling is_a: GO:0046580 ! negative regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031028 ! septation initiation signaling relationship: negatively_regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031031 name: positive regulation of septation initiation signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "activation of septation initiation signaling" NARROW [] synonym: "positive regulation of septation initiation network" EXACT [] synonym: "positive regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of septation initiation signalling" EXACT [] synonym: "stimulation of septation initiation signaling" NARROW [] synonym: "up regulation of septation initiation signaling" EXACT [] synonym: "up-regulation of septation initiation signaling" EXACT [] synonym: "upregulation of septation initiation signaling" EXACT [] is_a: GO:0010973 ! positive regulation of division septum assembly is_a: GO:0031029 ! regulation of septation initiation signaling is_a: GO:0046579 ! positive regulation of Ras protein signal transduction is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031028 ! septation initiation signaling relationship: positively_regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031033 name: myosin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin filament organisation" EXACT [GOC:mah] synonym: "myosin polymerization or depolymerization" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0031034 name: myosin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin polymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0031035 name: myosin filament disassembly namespace: biological_process def: "The disassembly of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0043624 ! cellular protein complex disassembly [Term] id: GO:0031036 name: myosin II filament assembly namespace: biological_process def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II polymerization" RELATED [] is_a: GO:0031034 ! myosin filament assembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031037 name: myosin II filament disassembly namespace: biological_process def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II depolymerization" RELATED [] is_a: GO:0031035 ! myosin filament disassembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031038 name: myosin II filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin II filament organisation" EXACT [GOC:mah] synonym: "myosin II polymerization or depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization [Term] id: GO:0031039 name: macronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] xref: Wikipedia:Macronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031040 name: micronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] xref: Wikipedia:Micronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031041 name: O-glycan processing, core 5 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031042 name: O-glycan processing, core 6 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031043 name: O-glycan processing, core 7 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031044 name: O-glycan processing, core 8 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule [Term] id: GO:0031047 name: gene silencing by RNA namespace: biological_process def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016458 ! gene silencing [Term] id: GO:0031048 name: chromatin silencing by small RNA namespace: biological_process def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns] synonym: "RNA interference-like chromatin silencing" EXACT [] synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] synonym: "RNA-mediated TGS" BROAD [] synonym: "RNA-mediated transcriptional silencing" EXACT [] synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw] synonym: "RNAi-like chromatin silencing" EXACT [] synonym: "small RNA-mediated heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0031049 name: programmed DNA elimination namespace: biological_process def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0031050 name: dsRNA processing namespace: biological_process def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns] synonym: "double-stranded RNA fragmentation" RELATED [] synonym: "dsRNA fragmentation" RELATED [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031051 name: scnRNA processing namespace: biological_process def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465] synonym: "scnRNA production" BROAD [] is_a: GO:0031050 ! dsRNA processing relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031052 name: chromosome breakage namespace: biological_process def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031053 name: primary miRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354] synonym: "pri-miRNA processing" EXACT [] synonym: "primary microRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031054 name: pre-miRNA processing namespace: biological_process def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354] synonym: "pre-microRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031055 name: chromatin remodeling at centromere namespace: biological_process def: "Dynamic structural changes in centromeric DNA." [GOC:mah] is_a: GO:0006338 ! chromatin remodeling [Term] id: GO:0031056 name: regulation of histone modification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016570 ! histone modification relationship: regulates GO:0016570 ! histone modification [Term] id: GO:0031057 name: negative regulation of histone modification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "down regulation of histone modification" EXACT [] synonym: "down-regulation of histone modification" EXACT [] synonym: "downregulation of histone modification" EXACT [] synonym: "inhibition of histone modification" NARROW [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016570 ! histone modification relationship: negatively_regulates GO:0016570 ! histone modification [Term] id: GO:0031058 name: positive regulation of histone modification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "activation of histone modification" NARROW [] synonym: "stimulation of histone modification" NARROW [] synonym: "up regulation of histone modification" EXACT [] synonym: "up-regulation of histone modification" EXACT [] synonym: "upregulation of histone modification" EXACT [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016570 ! histone modification relationship: positively_regulates GO:0016570 ! histone modification [Term] id: GO:0031059 name: histone deacetylation at centromere namespace: biological_process def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0016575 ! histone deacetylation [Term] id: GO:0031060 name: regulation of histone methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016571 ! histone methylation relationship: regulates GO:0016571 ! histone methylation [Term] id: GO:0031061 name: negative regulation of histone methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "down regulation of histone methylation" EXACT [] synonym: "down-regulation of histone methylation" EXACT [] synonym: "downregulation of histone methylation" EXACT [] synonym: "inhibition of histone methylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016571 ! histone methylation relationship: negatively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031062 name: positive regulation of histone methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "activation of histone methylation" NARROW [] synonym: "stimulation of histone methylation" NARROW [] synonym: "up regulation of histone methylation" EXACT [] synonym: "up-regulation of histone methylation" EXACT [] synonym: "upregulation of histone methylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016571 ! histone methylation relationship: positively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031063 name: regulation of histone deacetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0090311 ! regulation of protein deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016575 ! histone deacetylation relationship: regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031064 name: negative regulation of histone deacetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "down regulation of histone deacetylation" EXACT [] synonym: "down-regulation of histone deacetylation" EXACT [] synonym: "downregulation of histone deacetylation" EXACT [] synonym: "inhibition of histone deacetylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016575 ! histone deacetylation relationship: negatively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031065 name: positive regulation of histone deacetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "activation of histone deacetylation" NARROW [] synonym: "stimulation of histone deacetylation" NARROW [] synonym: "up regulation of histone deacetylation" EXACT [] synonym: "up-regulation of histone deacetylation" EXACT [] synonym: "upregulation of histone deacetylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation is_a: GO:0090312 ! positive regulation of protein deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016575 ! histone deacetylation relationship: positively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031066 name: regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0031063 ! regulation of histone deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031059 ! histone deacetylation at centromere relationship: regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031067 name: negative regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah] synonym: "down regulation of histone deacetylation at centromere" EXACT [] synonym: "down-regulation of histone deacetylation at centromere" EXACT [] synonym: "downregulation of histone deacetylation at centromere" EXACT [] synonym: "inhibition of histone deacetylation at centromere" NARROW [] is_a: GO:0031064 ! negative regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031059 ! histone deacetylation at centromere relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031068 name: positive regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] synonym: "activation of histone deacetylation at centromere" NARROW [] synonym: "stimulation of histone deacetylation at centromere" NARROW [] synonym: "up regulation of histone deacetylation at centromere" EXACT [] synonym: "up-regulation of histone deacetylation at centromere" EXACT [] synonym: "upregulation of histone deacetylation at centromere" EXACT [] is_a: GO:0031065 ! positive regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031059 ! histone deacetylation at centromere relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031069 name: hair follicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0022405 ! hair cycle process relationship: part_of GO:0001942 ! hair follicle development relationship: part_of GO:0048730 ! epidermis morphogenesis [Term] id: GO:0031070 name: intronic snoRNA processing namespace: biological_process def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw] is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0031071 name: cysteine desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7] synonym: "IscS" RELATED [EC:2.8.1.7] synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7] synonym: "NIFS" RELATED [EC:2.8.1.7] synonym: "SufS" RELATED [EC:2.8.1.7] xref: EC:2.8.1.7 xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" xref: Reactome:R-HSA-947514 "NFS1 transfers sulfur from cysteine onto MOCS3" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0031072 name: heat shock protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] is_a: GO:0005515 ! protein binding [Term] id: GO:0031073 name: cholesterol 26-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0031074 name: nucleocytoplasmic transport complex namespace: cellular_component def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "nucleocytoplasmic shuttling complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031077 name: post-embryonic camera-type eye development namespace: biological_process def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "post-embryonic camera-style eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0031078 name: histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] is_a: GO:0004407 ! histone deacetylase activity relationship: part_of GO:0070932 ! histone H3 deacetylation [Term] id: GO:0031079 name: obsolete picornain 3C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] comment: This term was made obsolete because it represents a gene product. synonym: "3C protease activity" EXACT [EC:3.4.22.28] synonym: "3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "picornain 3C activity" EXACT [] synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "protease 3C" RELATED [EC:3.4.22.28] synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] xref: EC:3.4.22.28 is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0031080 name: nuclear pore outer ring namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "Nup107-120 complex" EXACT [] synonym: "Nup107-160 complex" EXACT [] synonym: "Nup84 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0031081 name: nuclear pore distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah] synonym: "positioning of nuclear pores" RELATED [] is_a: GO:0006997 ! nucleus organization is_a: GO:0051664 ! nuclear pore localization [Term] id: GO:0031082 name: BLOC complex namespace: cellular_component def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] subset: goslim_pir synonym: "BLOC-1 related complex" EXACT [PMID:25898167] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0031083 name: BLOC-1 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031084 name: BLOC-2 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031085 name: BLOC-3 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031086 name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay namespace: biological_process def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent mRNA decay" EXACT [] synonym: "deadenylylation-independent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0031087 name: deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] synonym: "deadenylylation-independent decapping" EXACT [] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis is_a: GO:0110156 ! methylguanosine-cap decapping relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [Term] id: GO:0031088 name: platelet dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031089 name: platelet dense granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031091 name: platelet alpha granule namespace: cellular_component def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] synonym: "platelet alpha-granule" EXACT [] xref: Wikipedia:Platelet_alpha-granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0031092 name: platelet alpha granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule membrane" EXACT [] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031093 name: platelet alpha granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031094 name: platelet dense tubular network namespace: cellular_component def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0031095 name: platelet dense tubular network membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031096 name: platelet dense tubular network lumen namespace: cellular_component def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031097 name: medial cortex namespace: cellular_component def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789] synonym: "medial ring" EXACT [GOC:vw] is_a: GO:0099738 ! cell cortex region relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0031098 name: stress-activated protein kinase signaling cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] synonym: "JNK signaling pathway" NARROW [] synonym: "JNK signalling pathway" NARROW [] synonym: "SAPK signaling pathway" EXACT [] synonym: "SAPK signalling pathway" EXACT [] synonym: "stress-activated protein kinase signaling pathway" EXACT [] synonym: "stress-activated protein kinase signalling pathway" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031099 name: regeneration namespace: biological_process def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] xref: Wikipedia:Regeneration_(biology) is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0031100 name: animal organ regeneration namespace: biological_process def: "The regrowth of a lost or destroyed animal organ." [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0048513 ! animal organ development [Term] id: GO:0031101 name: fin regeneration namespace: biological_process def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0031102 name: neuron projection regeneration namespace: biological_process def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] synonym: "neurite regeneration" NARROW [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0031175 ! neuron projection development is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0031103 name: axon regeneration namespace: biological_process def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0031102 ! neuron projection regeneration is_a: GO:0048678 ! response to axon injury is_a: GO:0061564 ! axon development [Term] id: GO:0031104 name: dendrite regeneration namespace: biological_process def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0016358 ! dendrite development is_a: GO:0031102 ! neuron projection regeneration [Term] id: GO:0031105 name: septin complex namespace: cellular_component def: "A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005938 ! cell cortex relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0031106 name: septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] synonym: "septin ring organisation" EXACT [] is_a: GO:0032185 ! septin cytoskeleton organization [Term] id: GO:0031107 name: septin ring disassembly namespace: biological_process def: "The controlled breakdown of a septin ring." [GOC:mah] is_a: GO:0031106 ! septin ring organization is_a: GO:1903008 ! organelle disassembly [Term] id: GO:0031108 name: holo-[acyl-carrier-protein] biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg] synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] anabolism" EXACT [] synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] formation" EXACT [] synonym: "holo-[acyl-carrier-protein] synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031109 ! microtubule polymerization or depolymerization relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046785 ! microtubule polymerization relationship: regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007019 ! microtubule depolymerization relationship: regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046785 ! microtubule polymerization relationship: negatively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046785 ! microtubule polymerization relationship: positively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007019 ! microtubule depolymerization relationship: positively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031118 name: rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001522 ! pseudouridine synthesis [Term] id: GO:0031119 name: tRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0006400 ! tRNA modification [Term] id: GO:0031120 name: snRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0040031 ! snRNA modification [Term] id: GO:0031121 name: equatorial microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw] synonym: "equatorial microtubule organisation" EXACT [] synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0031123 name: RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] synonym: "RNA 3' end processing" EXACT [] xref: MIPS_funcat:11.04.03.05 is_a: GO:0006396 ! RNA processing [Term] id: GO:0031124 name: mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' end processing" EXACT [] is_a: GO:0006397 ! mRNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0031125 name: rRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah] synonym: "rRNA 3' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031126 name: snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah] synonym: "snoRNA 3' end processing" EXACT [] is_a: GO:0043144 ! snoRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031127 name: alpha-(1,2)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage." [GOC:mah] synonym: "alpha-(1->2)-fucosyltransferase activity" EXACT [] synonym: "alpha-1,2-fucosyltransferase activity" EXACT [] is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment [Term] id: GO:0031129 name: inductive cell-cell signaling namespace: biological_process def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah] synonym: "inductive cell-cell signalling" EXACT [] is_a: GO:0031128 ! developmental induction [Term] id: GO:0031130 name: creation of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031131 name: reception of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah] is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031132 name: serine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH." [EC:1.1.1.276, RHEA:21596] synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276] xref: EC:1.1.1.276 xref: KEGG_REACTION:R06126 xref: MetaCyc:RXN0-2201 xref: RHEA:21596 xref: Wikipedia:Serine_3-dehydrogenase is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0031133 name: regulation of axon diameter namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0032536 ! regulation of cell projection size is_a: GO:0050770 ! regulation of axonogenesis [Term] id: GO:0031134 name: sister chromatid biorientation namespace: biological_process def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] synonym: "chromosome biorientation" EXACT [] synonym: "sister kinetochore biorientation" EXACT [] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: part_of GO:0000819 ! sister chromatid segregation [Term] id: GO:0031135 name: negative regulation of conjugation namespace: biological_process def: "Any process that decreases the rate of conjugation." [GOC:mah] synonym: "down regulation of conjugation" EXACT [] synonym: "down-regulation of conjugation" EXACT [] synonym: "downregulation of conjugation" EXACT [] synonym: "inhibition of conjugation" NARROW [] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000746 ! conjugation relationship: negatively_regulates GO:0000746 ! conjugation [Term] id: GO:0031136 name: positive regulation of conjugation namespace: biological_process def: "Any process that increases the rate or frequency of conjugation." [GOC:mah] synonym: "activation of conjugation" NARROW [] synonym: "stimulation of conjugation" NARROW [] synonym: "up regulation of conjugation" EXACT [] synonym: "up-regulation of conjugation" EXACT [] synonym: "upregulation of conjugation" EXACT [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000746 ! conjugation relationship: positively_regulates GO:0000746 ! conjugation [Term] id: GO:0031137 name: regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] is_a: GO:0046999 ! regulation of conjugation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000747 ! conjugation with cellular fusion relationship: regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031138 name: negative regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "down regulation of conjugation with cellular fusion" EXACT [] synonym: "down-regulation of conjugation with cellular fusion" EXACT [] synonym: "downregulation of conjugation with cellular fusion" EXACT [] synonym: "inhibition of conjugation with cellular fusion" NARROW [] is_a: GO:0031135 ! negative regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000747 ! conjugation with cellular fusion relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031139 name: positive regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "activation of conjugation with cellular fusion" NARROW [] synonym: "stimulation of conjugation with cellular fusion" NARROW [] synonym: "up regulation of conjugation with cellular fusion" EXACT [] synonym: "up-regulation of conjugation with cellular fusion" EXACT [] synonym: "upregulation of conjugation with cellular fusion" EXACT [] is_a: GO:0031136 ! positive regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031140 name: induction of conjugation upon nutrient starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah] is_a: GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0031141 name: induction of conjugation upon carbon starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah] is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031142 name: induction of conjugation upon nitrogen starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031143 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732] subset: goslim_pir synonym: "pseudopod" EXACT [] xref: Wikipedia:Pseudopod is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0031144 name: proteasome localization namespace: biological_process def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of proteasome localization" EXACT [] synonym: "proteasome localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization [Term] id: GO:0031145 name: anaphase-promoting complex-dependent catabolic process namespace: biological_process alt_id: GO:0008054 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "cyclin breakdown" NARROW [] synonym: "cyclin catabolic process" NARROW [] synonym: "cyclin catabolism" NARROW [] synonym: "cyclin degradation" NARROW [] synonym: "degradation of cyclin" NARROW [] synonym: "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW [] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0031146 name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0031147 name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT [] synonym: "DIF-1 metabolic process" EXACT [] synonym: "DIF-1 metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0031148 name: DIF-1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT [] synonym: "DIF-1 biosynthesis" EXACT [] is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0031149 name: sorocarp stalk cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4338436] synonym: "stalk cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031150 ! sorocarp stalk development [Term] id: GO:0031150 name: sorocarp stalk development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [GOC:mtg_sensu, ISBN:0521583640, PMID:4338436] synonym: "sorophore development" EXACT [] synonym: "stalk development" BROAD [] synonym: "stalk formation" BROAD [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0031154 ! culmination involved in sorocarp development [Term] id: GO:0031151 name: histone methyltransferase activity (H3-K79 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT [] synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0034729 ! histone H3-K79 methylation [Term] id: GO:0031152 name: aggregation involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "aggregate development involved in sorocarp development" EXACT [] synonym: "aggregation during fruiting body development" EXACT [] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0098630 ! aggregation of unicellular organisms is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031153 name: slug development involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "migratory slug development during sorocarp development" NARROW [] synonym: "pseudoplasmodium biosynthesis" EXACT [] synonym: "pseudoplasmodium formation" EXACT [] synonym: "slug development during fruiting body development" EXACT [] synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb] synonym: "standing slug development during sorocarp development" NARROW [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031154 name: culmination involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "culminant development" EXACT [] synonym: "culmination during fruiting body development" EXACT [] synonym: "culmination during sorocarp development" RELATED [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031155 name: regulation of reproductive fruiting body development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive fruiting body development." [GOC:mah] synonym: "regulation of fruiting body formation" EXACT [] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030582 ! reproductive fruiting body development relationship: regulates GO:0030582 ! reproductive fruiting body development [Term] id: GO:0031156 name: regulation of sorocarp development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, PMID:4332228] synonym: "regulation of fruiting body development" BROAD [] synonym: "regulation of fruiting body formation" BROAD [] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030587 ! sorocarp development relationship: regulates GO:0030587 ! sorocarp development [Term] id: GO:0031157 name: regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:4338436] synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED [] synonym: "regulation of aggregation during fruiting body formation" RELATED [] is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031158 name: negative regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:5002049] synonym: "down regulation of aggregate size" EXACT [] synonym: "down-regulation of aggregate size" EXACT [] synonym: "downregulation of aggregate size" EXACT [] synonym: "inhibition of aggregate size" NARROW [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031159 name: positive regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that increases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:pg, PMID:5002049] synonym: "activation of aggregate size" NARROW [] synonym: "stimulation of aggregate size" NARROW [] synonym: "up regulation of aggregate size" EXACT [] synonym: "up-regulation of aggregate size" EXACT [] synonym: "upregulation of aggregate size" EXACT [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031160 name: spore wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0031161 name: phosphatidylinositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah] synonym: "phosphatidylinositol breakdown" EXACT [] synonym: "phosphatidylinositol catabolism" EXACT [] synonym: "phosphatidylinositol degradation" EXACT [] synonym: "PtdIns catabolic process" EXACT [] synonym: "PtdIns catabolism" EXACT [] is_a: GO:0046475 ! glycerophospholipid catabolic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0031162 name: sulfur incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0006790 ! sulfur compound metabolic process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0031163 name: metallo-sulfur cluster assembly namespace: biological_process def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr] synonym: "metallo-sulfur cluster biosynthesis" RELATED [] synonym: "metallo-sulphur cluster assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0031164 name: contractile vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000331 ! contractile vacuole [Term] id: GO:0031165 name: integral component of contractile vacuolar membrane namespace: cellular_component def: "The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:pg] synonym: "integral to contractile vacuolar membrane" EXACT [] is_a: GO:0031166 ! integral component of vacuolar membrane is_a: GO:0031311 ! intrinsic component of contractile vacuolar membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031166 name: integral component of vacuolar membrane namespace: cellular_component def: "The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:mah] synonym: "integral to vacuolar membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031310 ! intrinsic component of vacuolar membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0031167 name: rRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001510 ! RNA methylation [Term] id: GO:0031168 name: ferrichrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] synonym: "ferrichrome metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0031169 name: ferrichrome biosynthetic process namespace: biological_process alt_id: GO:0031199 alt_id: GO:0031200 def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] synonym: "ferrichrome anabolism" EXACT [] synonym: "ferrichrome biosynthesis" EXACT [] synonym: "ferrichrome biosynthetic process, peptide formation" NARROW [] synonym: "ferrichrome biosynthetic process, peptide modification" NARROW [] synonym: "ferrichrome formation" EXACT [] synonym: "ferrichrome synthesis" EXACT [] is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid is_a: GO:0031168 ! ferrichrome metabolic process [Term] id: GO:0031170 name: ferricrocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin metabolism" EXACT [] is_a: GO:0031168 ! ferrichrome metabolic process [Term] id: GO:0031171 name: ferricrocin biosynthetic process namespace: biological_process alt_id: GO:0031185 alt_id: GO:0031186 def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin anabolism" EXACT [] synonym: "ferricrocin biosynthesis" EXACT [] synonym: "ferricrocin biosynthetic process, peptide formation" NARROW [] synonym: "ferricrocin biosynthetic process, peptide modification" NARROW [] synonym: "ferricrocin formation" EXACT [] synonym: "ferricrocin synthesis" EXACT [] is_a: GO:0031169 ! ferrichrome biosynthetic process is_a: GO:0031170 ! ferricrocin metabolic process [Term] id: GO:0031172 name: ornithine N5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635] synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128] xref: MetaCyc:RXN-11128 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0031173 name: otolith mineralization completed early in development namespace: biological_process def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] synonym: "otoconia mineralization" EXACT [] synonym: "otoconium mineralization" EXACT [] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031174 name: lifelong otolith mineralization namespace: biological_process def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: part_of GO:0048666 ! neuron development relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031176 name: endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "xylanase" BROAD [EC:3.2.1.8] xref: EC:3.2.1.8 xref: MetaCyc:3.2.1.8-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0031177 name: phosphopantetheine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw] is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0048037 ! cofactor binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0031179 name: peptide modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0031201 name: SNARE complex namespace: cellular_component def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031203 name: posttranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814] synonym: "posttranslational protein membrane targeting, docking" EXACT [] synonym: "protein docking during posttranslational protein targeting to membrane" EXACT [] synonym: "Sec-translated protein complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane [Term] id: GO:0031204 name: posttranslational protein targeting to membrane, translocation namespace: biological_process def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] synonym: "posttranslational protein membrane targeting, translocation" EXACT [] synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane [Term] id: GO:0031205 name: endoplasmic reticulum Sec complex namespace: cellular_component def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809] subset: goslim_pir is_a: GO:0098796 ! membrane protein complex relationship: has_part GO:0005784 ! Sec61 translocon complex relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0031207 name: Sec62/Sec63 complex namespace: cellular_component def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] synonym: "ER protein translocation subcomplex" EXACT [] synonym: "Sec62/63 complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex [Term] id: GO:0031208 name: POZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] synonym: "broad-complex, tramtrack, and bric-a-brac domain binding" EXACT [] synonym: "BTB domain" EXACT [PMID:22621901] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0031209 name: SCAR complex namespace: cellular_component def: "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101] synonym: "WAVE complex" EXACT [] synonym: "WAVE regulatory complex" EXACT [] synonym: "WRC" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031210 name: phosphatidylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732] is_a: GO:0005543 ! phospholipid binding is_a: GO:0050997 ! quaternary ammonium group binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0031211 name: endoplasmic reticulum palmitoyltransferase complex namespace: cellular_component def: "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] is_a: GO:0098796 ! membrane protein complex is_a: GO:1905961 ! protein-cysteine S-palmitoyltransferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031213 name: RSF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "remodeling and spacing factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0031214 name: biomineral tissue development namespace: biological_process def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] xref: Wikipedia:Biomineralization is_a: GO:0009888 ! tissue development is_a: GO:0110148 ! biomineralization relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0031215 name: shell calcification namespace: biological_process def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736] is_a: GO:0031214 ! biomineral tissue development [Term] id: GO:0031216 name: neopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135] synonym: "pullulanase II activity" EXACT [] xref: EC:3.2.1.135 xref: MetaCyc:3.2.1.135-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031217 name: glucan 1,4-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] synonym: "1,4-beta-D-glucan glucohydrolase activity" BROAD [EC:3.2.1.74] synonym: "beta-1,4-beta-glucanase activity" BROAD [EC:3.2.1.74] synonym: "beta-1,4-glucanase activity" BROAD [] synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74] synonym: "exo-1,4-beta-glucanase activity" EXACT [] synonym: "exo-1,4-beta-glucosidase activity" EXACT [] synonym: "exo-beta-1,4-glucanase activity" EXACT [] synonym: "exo-beta-1,4-glucosidase activity" EXACT [] synonym: "exocellulase activity" EXACT [] xref: EC:3.2.1.74 xref: MetaCyc:3.2.1.74-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0031218 name: arabinogalactan endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89] synonym: "arabinogalactanase activity" EXACT [] synonym: "endo-1,4-beta-galactanase activity" EXACT [] synonym: "galactanase activity" EXACT [] xref: EC:3.2.1.89 xref: MetaCyc:3.2.1.89-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0031219 name: levanase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65] synonym: "levan hydrolase activity" EXACT [] xref: EC:3.2.1.65 xref: MetaCyc:3.2.1.65-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031220 name: maltodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] xref: MetaCyc:RXN-9025 xref: MetaCyc:RXN0-5182 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0031221 name: arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] synonym: "arabinan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0031222 name: arabinan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] synonym: "arabinan breakdown" EXACT [] synonym: "arabinan catabolism" EXACT [] synonym: "arabinan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0031223 name: auditory behavior namespace: biological_process def: "The behavior of an organism in response to a sound." [GOC:pr, GOC:rc] synonym: "auditory behaviour" EXACT [] synonym: "behavioral response to sound" EXACT [] synonym: "behavioural response to sound" EXACT [] is_a: GO:0007638 ! mechanosensory behavior relationship: part_of GO:0010996 ! response to auditory stimulus [Term] id: GO:0031224 name: intrinsic component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: goslim_metagenomics synonym: "intrinsic to membrane" NARROW [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016020 ! membrane [Term] id: GO:0031225 name: anchored component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] synonym: "anchored to membrane" EXACT [] is_a: GO:0031224 ! intrinsic component of membrane [Term] id: GO:0031226 name: intrinsic component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plasma membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0031227 name: intrinsic component of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to endoplasmic reticulum membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031228 name: intrinsic component of Golgi membrane namespace: cellular_component def: "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to Golgi membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0000139 ! Golgi membrane relationship: part_of GO:0000139 ! Golgi membrane [Term] id: GO:0031229 name: intrinsic component of nuclear inner membrane namespace: cellular_component def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to nuclear inner membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005637 ! nuclear inner membrane relationship: part_of GO:0005637 ! nuclear inner membrane [Term] id: GO:0031230 name: intrinsic component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to cell outer membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0009279 ! cell outer membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031231 name: intrinsic component of peroxisomal membrane namespace: cellular_component def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to peroxisomal membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005778 ! peroxisomal membrane relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0031232 name: extrinsic component of external side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "extrinsic to external side of plasma membrane" NARROW [] is_a: GO:0019897 ! extrinsic component of plasma membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0009897 ! external side of plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031233 name: intrinsic component of external side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] synonym: "intrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "intrinsic to external side of plasma membrane" NARROW [] is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0031226 ! intrinsic component of plasma membrane intersection_of: part_of GO:0009897 ! external side of plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031234 name: extrinsic component of cytoplasmic side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] comment: Consider also annotating to 'cell cortex ; GO:0005938'. synonym: "extrinsic to cytoplasmic side of plasma membrane" NARROW [] synonym: "extrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "extrinsic to internal side of plasma membrane" EXACT [] is_a: GO:0019897 ! extrinsic component of plasma membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane relationship: part_of GO:0005622 ! intracellular relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0031235 name: intrinsic component of the cytoplasmic side of the plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah] synonym: "intrinsic to cytoplasmic side of plasma membrane" NARROW [] synonym: "intrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "intrinsic to internal side of plasma membrane" EXACT [] is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0031236 name: extrinsic component of periplasmic side of plasma membrane namespace: cellular_component alt_id: GO:0031238 def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to external leaflet of plasma membrane, in periplasmic space" NARROW [GOC:ab] synonym: "extrinsic to external side of plasma membrane, in periplasmic space" NARROW [] is_a: GO:0031232 ! extrinsic component of external side of plasma membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane relationship: part_of GO:0098567 ! periplasmic side of plasma membrane [Term] id: GO:0031237 name: intrinsic component of periplasmic side of plasma membrane namespace: cellular_component alt_id: GO:0031239 def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external leaflet of plasma membrane, in periplasmic space" EXACT [GOC:ab] synonym: "intrinsic to periplasmic side of plasma membrane" EXACT [] is_a: GO:0031233 ! intrinsic component of external side of plasma membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane relationship: part_of GO:0098567 ! periplasmic side of plasma membrane [Term] id: GO:0031240 name: external side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "external side of outer membrane" RELATED [] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031241 name: periplasmic side of cell outer membrane namespace: cellular_component def: "The side (leaflet) of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] comment: In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane. synonym: "internal leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "internal side of cell outer membrane" EXACT [] synonym: "internal side of outer membrane" EXACT [] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031242 name: extrinsic component of external side of cell outer membrane namespace: cellular_component def: "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "extrinsic to external side of cell outer membrane" NARROW [] synonym: "extrinsic to external side of outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic component of cell outer membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0031240 ! external side of cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031243 name: intrinsic component of external side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "intrinsic to external side of cell outer membrane" NARROW [] synonym: "intrinsic to external side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic component of cell outer membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031240 ! external side of cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031244 name: extrinsic component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to cell outer membrane" NARROW [] is_a: GO:0019898 ! extrinsic component of membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0009279 ! cell outer membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031245 name: extrinsic component of periplasmic side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to internal leaflet of cell outer membrane" NARROW [GOC:ab] synonym: "extrinsic to internal side of cell outer membrane" EXACT [] synonym: "extrinsic to internal side of outer membrane" EXACT [] synonym: "extrinsic to periplasmic side of cell outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic component of cell outer membrane intersection_of: GO:0031244 ! extrinsic component of cell outer membrane intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane [Term] id: GO:0031246 name: intrinsic component of periplasmic side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external side of cell outer membrane" NARROW [] synonym: "intrinsic to internal leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "intrinsic to internal side of cell outer membrane" EXACT [] synonym: "intrinsic to internal side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic component of cell outer membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane [Term] id: GO:0031247 name: actin rod assembly namespace: biological_process def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699] synonym: "actin rod formation" RELATED [GOC:mah] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0031248 name: protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] subset: goslim_pir is_a: GO:1902493 ! acetyltransferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031249 name: denatured protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with denatured proteins." [GOC:mlg] comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. is_a: GO:0005515 ! protein binding [Term] id: GO:0031250 name: anaerobic ribonucleoside-triphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031251 name: PAN complex namespace: cellular_component def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] synonym: "poly(A) nuclease complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:mah] {comment="GOC:krc"} synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0031254 name: cell trailing edge namespace: cellular_component def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "back of cell" EXACT [] synonym: "trailing edge" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031255 name: lateral part of motile cell namespace: cellular_component def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg, GOC:pr] is_a: GO:0097574 ! lateral part of cell [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0031257 name: cell trailing edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] synonym: "trailing edge membrane" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0031254 ! cell trailing edge [Term] id: GO:0031258 name: lamellipodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0030027 ! lamellipodium [Term] id: GO:0031259 name: uropod membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] synonym: "uropodium membrane" EXACT [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031257 ! cell trailing edge membrane relationship: part_of GO:0001931 ! uropod [Term] id: GO:0031260 name: pseudopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0031143 ! pseudopodium [Term] id: GO:0031261 name: DNA replication preinitiation complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] synonym: "pre-IC" EXACT [] is_a: GO:0032993 ! protein-DNA complex relationship: has_part GO:0005656 ! nuclear pre-replicative complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0031262 name: Ndc80 complex namespace: cellular_component def: "An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25." [GOC:krc, GOC:vw, PMID:15509863, PMID:15661517, PMID:28502666] synonym: "Nuf2-Ndc80 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0031617 ! NMS complex [Term] id: GO:0031263 name: ATPase-coupled amine transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] synonym: "amine ABC transporter" NARROW [] synonym: "amine-transporting ATPase activity" EXACT [] synonym: "ATP-dependent amine transporter activity" EXACT [] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0031264 name: death-inducing signaling complex namespace: cellular_component def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815] comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. subset: goslim_pir synonym: "death receptor-induced signaling complex" EXACT [] synonym: "death receptor-induced signalling complex" EXACT [] synonym: "death-inducing signalling complex" EXACT [] synonym: "DISC" EXACT [] synonym: "DISC protein complex" EXACT [] xref: Wikipedia:Death-inducing_signaling_complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0031265 name: CD95 death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "CD95 death-inducing signalling complex" EXACT [] synonym: "CD95 DISC" EXACT [] synonym: "Fas death-inducing signaling complex" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031266 name: TRAIL death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "TRAIL death-inducing signalling complex" EXACT [] synonym: "TRAIL DISC" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031267 name: small GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah] is_a: GO:0051020 ! GTPase binding [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0031269 name: pseudopodium assembly namespace: biological_process def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "pseudopodium extension" EXACT [] synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031268 ! pseudopodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0031270 name: pseudopodium retraction namespace: biological_process def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg] is_a: GO:0031268 ! pseudopodium organization [Term] id: GO:0031271 name: lateral pseudopodium assembly namespace: biological_process def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031269 ! pseudopodium assembly [Term] id: GO:0031272 name: regulation of pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "regulation of pseudopodium formation" RELATED [] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031269 ! pseudopodium assembly relationship: regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031273 name: negative regulation of pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "down regulation of pseudopodium formation" RELATED [] synonym: "down-regulation of pseudopodium formation" RELATED [] synonym: "downregulation of pseudopodium formation" RELATED [] synonym: "inhibition of pseudopodium formation" NARROW [] synonym: "negative regulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031269 ! pseudopodium assembly relationship: negatively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031274 name: positive regulation of pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "activation of pseudopodium formation" NARROW [] synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] synonym: "stimulation of pseudopodium formation" NARROW [] synonym: "up regulation of pseudopodium formation" RELATED [] synonym: "up-regulation of pseudopodium formation" RELATED [] synonym: "upregulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031269 ! pseudopodium assembly relationship: positively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031275 name: regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031272 ! regulation of pseudopodium assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031271 ! lateral pseudopodium assembly relationship: regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031276 name: negative regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "down regulation of lateral pseudopodium formation" RELATED [] synonym: "down-regulation of lateral pseudopodium formation" RELATED [] synonym: "downregulation of lateral pseudopodium formation" RELATED [] synonym: "inhibition of lateral pseudopodium formation" NARROW [] synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph] is_a: GO:0031273 ! negative regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031271 ! lateral pseudopodium assembly relationship: negatively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031277 name: positive regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "activation of lateral pseudopodium formation" NARROW [] synonym: "positive regulation of lateral pseudopodium formation" RELATED [] synonym: "stimulation of lateral pseudopodium formation" NARROW [] synonym: "up regulation of lateral pseudopodium formation" RELATED [] synonym: "up-regulation of lateral pseudopodium formation" RELATED [] synonym: "upregulation of lateral pseudopodium formation" RELATED [] is_a: GO:0031274 ! positive regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031271 ! lateral pseudopodium assembly relationship: positively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031278 name: alpha-1,2-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0031279 name: regulation of cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009975 ! cyclase activity relationship: regulates GO:0009975 ! cyclase activity [Term] id: GO:0031280 name: negative regulation of cyclase activity namespace: biological_process def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah] synonym: "down regulation of cyclase activity" EXACT [] synonym: "down-regulation of cyclase activity" EXACT [] synonym: "downregulation of cyclase activity" EXACT [] synonym: "inhibition of cyclase activity" NARROW [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043086 ! negative regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009975 ! cyclase activity relationship: negatively_regulates GO:0009975 ! cyclase activity [Term] id: GO:0031281 name: positive regulation of cyclase activity namespace: biological_process def: "Any process that activates or increases the activity of a cyclase." [GOC:mah] synonym: "activation of cyclase activity" NARROW [] synonym: "stimulation of cyclase activity" NARROW [] synonym: "up regulation of cyclase activity" EXACT [] synonym: "up-regulation of cyclase activity" EXACT [] synonym: "upregulation of cyclase activity" EXACT [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043085 ! positive regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009975 ! cyclase activity relationship: positively_regulates GO:0009975 ! cyclase activity [Term] id: GO:0031282 name: regulation of guanylate cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0051339 ! regulation of lyase activity is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004383 ! guanylate cyclase activity relationship: regulates GO:0004383 ! guanylate cyclase activity [Term] id: GO:0031283 name: negative regulation of guanylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "down regulation of guanylate cyclase activity" EXACT [] synonym: "down-regulation of guanylate cyclase activity" EXACT [] synonym: "downregulation of guanylate cyclase activity" EXACT [] synonym: "inhibition of guanylate cyclase activity" NARROW [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process intersection_of: GO:0043086 ! negative regulation of catalytic activity intersection_of: negatively_regulates GO:0004383 ! guanylate cyclase activity relationship: negatively_regulates GO:0004383 ! guanylate cyclase activity [Term] id: GO:0031284 name: positive regulation of guanylate cyclase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "activation of guanylate cyclase activity" NARROW [] synonym: "stimulation of guanylate cyclase activity" NARROW [] synonym: "up regulation of guanylate cyclase activity" EXACT [] synonym: "up-regulation of guanylate cyclase activity" EXACT [] synonym: "upregulation of guanylate cyclase activity" EXACT [] is_a: GO:0031281 ! positive regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051349 ! positive regulation of lyase activity is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004383 ! guanylate cyclase activity relationship: positively_regulates GO:0004383 ! guanylate cyclase activity [Term] id: GO:0031285 name: regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] synonym: "regulation of stalk cell differentiation" EXACT [] is_a: GO:0031156 ! regulation of sorocarp development is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031149 ! sorocarp stalk cell differentiation relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031286 name: negative regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] synonym: "down regulation of stalk cell differentiation" EXACT [] synonym: "down-regulation of stalk cell differentiation" EXACT [] synonym: "downregulation of stalk cell differentiation" EXACT [] synonym: "inhibition of stalk cell differentiation" NARROW [] synonym: "negative regulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0075262 ! negative regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031287 name: positive regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] synonym: "activation of stalk cell differentiation" NARROW [] synonym: "positive regulation of stalk cell differentiation" EXACT [] synonym: "stimulation of stalk cell differentiation" NARROW [] synonym: "up regulation of stalk cell differentiation" EXACT [] synonym: "up-regulation of stalk cell differentiation" EXACT [] synonym: "upregulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0075261 ! positive regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031288 name: sorocarp morphogenesis namespace: biological_process def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4332228] synonym: "fruiting body morphogenesis" BROAD [DDANAT:0000012] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031289 name: actin phosphorylation namespace: biological_process def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0030047 ! actin modification [Term] id: GO:0031290 name: retinal ganglion cell axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] synonym: "retinal ganglion cell axon pathfinding" EXACT [] is_a: GO:0007411 ! axon guidance [Term] id: GO:0031291 name: Ran protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0031292 name: gene conversion at mating-type locus, DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0022414 ! reproductive process intersection_of: GO:0000729 ! DNA double-strand break processing intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0031293 name: membrane protein intracellular domain proteolysis namespace: biological_process def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018] synonym: "membrane protein solubilization" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0031294 name: lymphocyte costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149] synonym: "lymphocyte co-stimulation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031295 name: T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149] synonym: "T cell co-stimulation" EXACT [] synonym: "T lymphocyte costimulation" EXACT [] synonym: "T-cell co-stimulation" EXACT [] synonym: "T-cell costimulation" EXACT [] synonym: "T-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0031296 name: B cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149] synonym: "B cell co-stimulation" EXACT [] synonym: "B lymphocyte co-stimulation" EXACT [] synonym: "B lymphocyte costimulation" EXACT [] synonym: "B-cell co-stimulation" EXACT [] synonym: "B-cell costimulation" EXACT [] synonym: "B-lymphocyte co-stimulation" EXACT [] synonym: "B-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050871 ! positive regulation of B cell activation [Term] id: GO:0031297 name: replication fork processing namespace: biological_process alt_id: GO:0034065 def: "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] synonym: "collapsed replication fork processing" EXACT [] synonym: "recovery from replication fork arrest" EXACT [] synonym: "recovery from replication fork arrest at rDNA locus" NARROW [] synonym: "recovery from replication fork stalling" EXACT [] synonym: "recovery from replication fork stalling at rDNA locus" NARROW [] synonym: "replication fork processing at rDNA locus" NARROW [] synonym: "replication fork processing at ribosomal DNA locus" NARROW [] synonym: "replication fork restart" RELATED [PMID:20842177] synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929] is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity [Term] id: GO:0031298 name: replication fork protection complex namespace: cellular_component def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] synonym: "replisome progression complex" EXACT [GOC:vw] synonym: "Swi1-Swi3 complex" NARROW [] synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043596 ! nuclear replication fork [Term] id: GO:0031299 name: taurine-pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [EC:2.6.1.77, RHEA:10420] synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77] synonym: "Tpa" RELATED [EC:2.6.1.77] xref: EC:2.6.1.77 xref: KEGG_REACTION:R05652 xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN xref: RHEA:10420 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0031300 name: intrinsic component of organelle membrane namespace: cellular_component def: "The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to organelle membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031090 ! organelle membrane relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031301 name: integral component of organelle membrane namespace: cellular_component def: "The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to organelle membrane" EXACT [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031302 name: intrinsic component of endosome membrane namespace: cellular_component def: "The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to endosome membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0010008 ! endosome membrane relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031303 name: integral component of endosome membrane namespace: cellular_component def: "The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to endosome membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031302 ! intrinsic component of endosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031304 name: intrinsic component of mitochondrial inner membrane namespace: cellular_component def: "The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to mitochondrial inner membrane" NARROW [] is_a: GO:0098573 ! intrinsic component of mitochondrial membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031305 name: integral component of mitochondrial inner membrane namespace: cellular_component def: "The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial inner membrane" EXACT [] is_a: GO:0031304 ! intrinsic component of mitochondrial inner membrane is_a: GO:0032592 ! integral component of mitochondrial membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031306 name: intrinsic component of mitochondrial outer membrane namespace: cellular_component def: "The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to mitochondrial outer membrane" NARROW [] is_a: GO:0098573 ! intrinsic component of mitochondrial membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005741 ! mitochondrial outer membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031307 name: integral component of mitochondrial outer membrane namespace: cellular_component def: "The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial outer membrane" NARROW [] is_a: GO:0031306 ! intrinsic component of mitochondrial outer membrane is_a: GO:0032592 ! integral component of mitochondrial membrane intersection_of: GO:0032592 ! integral component of mitochondrial membrane intersection_of: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031308 name: intrinsic component of nuclear outer membrane namespace: cellular_component def: "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to nuclear outer membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005640 ! nuclear outer membrane relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031309 name: integral component of nuclear outer membrane namespace: cellular_component def: "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to nuclear outer membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031308 ! intrinsic component of nuclear outer membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031310 name: intrinsic component of vacuolar membrane namespace: cellular_component def: "The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to vacuolar membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005774 ! vacuolar membrane relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0031311 name: intrinsic component of contractile vacuolar membrane namespace: cellular_component def: "The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to contractile vacuolar membrane" NARROW [] is_a: GO:0031310 ! intrinsic component of vacuolar membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031164 ! contractile vacuolar membrane relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031312 name: extrinsic component of organelle membrane namespace: cellular_component def: "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to organelle membrane" NARROW [] is_a: GO:0019898 ! extrinsic component of membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0031090 ! organelle membrane relationship: part_of GO:0031090 ! organelle membrane relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031313 name: extrinsic component of endosome membrane namespace: cellular_component def: "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to endosome membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0010008 ! endosome membrane relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031314 name: extrinsic component of mitochondrial inner membrane namespace: cellular_component def: "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to mitochondrial inner membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031315 name: extrinsic component of mitochondrial outer membrane namespace: cellular_component def: "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to mitochondrial outer membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005741 ! mitochondrial outer membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031316 name: extrinsic component of nuclear outer membrane namespace: cellular_component def: "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to nuclear outer membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005640 ! nuclear outer membrane relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031317 name: tripartite ATP-independent periplasmic transporter complex namespace: cellular_component def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg] synonym: "TRAP transporter complex" EXACT [] synonym: "TRAP-T transporter complex" EXACT [] is_a: GO:1990351 ! transporter complex [Term] id: GO:0031318 name: detection of folic acid namespace: biological_process def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "detection of folate" EXACT [] synonym: "folate detection" EXACT [] synonym: "folate sensing" EXACT [] synonym: "folic acid detection" EXACT [] synonym: "folic acid sensing" EXACT [] is_a: GO:0009594 ! detection of nutrient is_a: GO:0051593 ! response to folic acid [Term] id: GO:0031319 name: detection of cAMP namespace: biological_process def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg] synonym: "3',5'-cAMP detection" EXACT [] synonym: "3',5'-cAMP sensing" EXACT [] synonym: "cAMP detection" EXACT [] synonym: "cAMP sensing" EXACT [] synonym: "cyclic AMP detection" EXACT [] synonym: "detection of 3',5' cAMP" EXACT [] synonym: "detection of 3',5'-cAMP" EXACT [] synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT [] synonym: "detection of cyclic AMP" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051591 ! response to cAMP [Term] id: GO:0031320 name: hexitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0031321 name: ascospore-type prospore assembly namespace: biological_process def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore formation" EXACT [] synonym: "forespore formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030437 ! ascospore formation [Term] id: GO:0031322 name: ascospore-type prospore-specific spindle pole body remodeling namespace: biological_process def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw] synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah] synonym: "forespore specific spindle pole body remodeling" EXACT [] synonym: "forespore-specific spindle pole body remodeling" EXACT [] synonym: "prospore-specific spindle pole body remodeling" EXACT [] synonym: "sporulation-specific spindle pole body remodeling" EXACT [] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0031321 ! ascospore-type prospore assembly [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044237 ! cellular metabolic process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044237 ! cellular metabolic process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044249 ! cellular biosynthetic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044248 ! cellular catabolic process relationship: regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044248 ! cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031332 name: RNAi effector complex namespace: cellular_component def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] subset: goslim_pir is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0065003 ! protein-containing complex assembly relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0065003 ! protein-containing complex assembly relationship: positively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031335 name: regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000096 ! sulfur amino acid metabolic process relationship: regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031336 name: negative regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "down regulation of sulfur amino acid metabolic process" EXACT [] synonym: "down-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "downregulation of sulfur amino acid metabolic process" EXACT [] synonym: "inhibition of sulfur amino acid metabolic process" NARROW [] synonym: "negative regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031337 name: positive regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "activation of sulfur amino acid metabolic process" NARROW [] synonym: "positive regulation of sulfur amino acid metabolism" EXACT [] synonym: "stimulation of sulfur amino acid metabolic process" NARROW [] synonym: "up regulation of sulfur amino acid metabolic process" EXACT [] synonym: "up-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "upregulation of sulfur amino acid metabolic process" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000096 ! sulfur amino acid metabolic process relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006906 ! vesicle fusion relationship: regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006906 ! vesicle fusion relationship: negatively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006906 ! vesicle fusion relationship: positively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031341 name: regulation of cell killing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001906 ! cell killing relationship: regulates GO:0001906 ! cell killing [Term] id: GO:0031342 name: negative regulation of cell killing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] synonym: "down regulation of cell killing" EXACT [] synonym: "down-regulation of cell killing" EXACT [] synonym: "downregulation of cell killing" EXACT [] synonym: "inhibition of cell killing" NARROW [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001906 ! cell killing relationship: negatively_regulates GO:0001906 ! cell killing [Term] id: GO:0031343 name: positive regulation of cell killing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] synonym: "activation of cell killing" NARROW [] synonym: "stimulation of cell killing" NARROW [] synonym: "up regulation of cell killing" EXACT [] synonym: "up-regulation of cell killing" EXACT [] synonym: "upregulation of cell killing" EXACT [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001906 ! cell killing relationship: positively_regulates GO:0001906 ! cell killing [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030030 ! cell projection organization relationship: regulates GO:0030030 ! cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030030 ! cell projection organization relationship: negatively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030030 ! cell projection organization relationship: positively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006952 ! defense response relationship: regulates GO:0006952 ! defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006952 ! defense response relationship: negatively_regulates GO:0006952 ! defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006952 ! defense response relationship: positively_regulates GO:0006952 ! defense response [Term] id: GO:0031350 name: intrinsic component of plastid membrane namespace: cellular_component def: "The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0042170 ! plastid membrane relationship: part_of GO:0042170 ! plastid membrane [Term] id: GO:0031351 name: integral component of plastid membrane namespace: cellular_component def: "The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031350 ! intrinsic component of plastid membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0042170 ! plastid membrane [Term] id: GO:0031352 name: intrinsic component of plastid inner membrane namespace: cellular_component def: "The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid inner membrane" NARROW [] is_a: GO:0031350 ! intrinsic component of plastid membrane intersection_of: GO:0031350 ! intrinsic component of plastid membrane intersection_of: part_of GO:0009528 ! plastid inner membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0031353 name: integral component of plastid inner membrane namespace: cellular_component def: "The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid inner membrane" NARROW [] is_a: GO:0031351 ! integral component of plastid membrane is_a: GO:0031352 ! intrinsic component of plastid inner membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0031354 name: intrinsic component of plastid outer membrane namespace: cellular_component def: "The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid outer membrane" NARROW [] is_a: GO:0031350 ! intrinsic component of plastid membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0009527 ! plastid outer membrane relationship: part_of GO:0009527 ! plastid outer membrane [Term] id: GO:0031355 name: integral component of plastid outer membrane namespace: cellular_component def: "The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid outer membrane" NARROW [] is_a: GO:0031351 ! integral component of plastid membrane is_a: GO:0031354 ! intrinsic component of plastid outer membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009527 ! plastid outer membrane [Term] id: GO:0031356 name: intrinsic component of chloroplast inner membrane namespace: cellular_component def: "The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to chloroplast inner membrane" NARROW [] is_a: GO:0031352 ! intrinsic component of plastid inner membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0009706 ! chloroplast inner membrane relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031357 name: integral component of chloroplast inner membrane namespace: cellular_component def: "The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to chloroplast inner membrane" NARROW [] is_a: GO:0031353 ! integral component of plastid inner membrane is_a: GO:0031356 ! intrinsic component of chloroplast inner membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031358 name: intrinsic component of chloroplast outer membrane namespace: cellular_component def: "The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to chloroplast outer membrane" NARROW [] is_a: GO:0031354 ! intrinsic component of plastid outer membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0009707 ! chloroplast outer membrane relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0031359 name: integral component of chloroplast outer membrane namespace: cellular_component def: "The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to chloroplast outer membrane" NARROW [] is_a: GO:0031355 ! integral component of plastid outer membrane is_a: GO:0031358 ! intrinsic component of chloroplast outer membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0031360 name: intrinsic component of thylakoid membrane namespace: cellular_component def: "The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to thylakoid membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0042651 ! thylakoid membrane relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0031361 name: integral component of thylakoid membrane namespace: cellular_component def: "The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to thylakoid membrane" NARROW [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031360 ! intrinsic component of thylakoid membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0031362 name: anchored component of external side of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] synonym: "anchored to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "anchored to external side of plasma membrane" EXACT [] is_a: GO:0031233 ! intrinsic component of external side of plasma membrane is_a: GO:0046658 ! anchored component of plasma membrane intersection_of: GO:0046658 ! anchored component of plasma membrane intersection_of: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031363 name: N-terminal protein amino acid deamination namespace: biological_process def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0031364 name: N-terminal protein amino acid deamination, from side chain namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah] is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0031365 name: N-terminal protein amino acid modification namespace: biological_process alt_id: GO:0018409 def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah] synonym: "peptide or protein amino-terminal blocking" RELATED [] synonym: "peptide/protein amino-terminal blocking" RELATED [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0031366 name: N-terminal peptidyl-asparagine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031367 name: N-terminal peptidyl-glutamine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031368 name: obsolete Pro-X metallocarboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "Pro-X metallocarboxypeptidase activity" EXACT [] xref: EC:3.4.17.16 is_obsolete: true consider: GO:0004181 consider: GO:0008233 [Term] id: GO:0031369 name: translation initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0031370 name: eukaryotic initiation factor 4G binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] synonym: "eIF4G binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0031371 name: ubiquitin conjugating enzyme complex namespace: cellular_component def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] subset: goslim_pir synonym: "E2 complex" RELATED [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031372 name: UBC13-MMS2 complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] is_a: GO:0031371 ! ubiquitin conjugating enzyme complex [Term] id: GO:0031375 name: obsolete type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not. synonym: "type II FAS" EXACT [] synonym: "type II FAS complex" EXACT [] synonym: "type II fatty acid synthase" EXACT [] synonym: "type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031376 name: obsolete cytosolic type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] synonym: "cytosolic type II FAS complex" EXACT [] synonym: "cytosolic type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031377 name: obsolete mitochondrial type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthases are not complexes synonym: "mitochondrial type II FAS complex" EXACT [] synonym: "mitochondrial type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031378 name: obsolete plastid type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthase is not a complex. synonym: "plastid type II FAS complex" EXACT [] synonym: "plastid type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031379 name: RNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0031380 name: nuclear RNA-directed RNA polymerase complex namespace: cellular_component def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] synonym: "Rdr1 complex" NARROW [] synonym: "RDRC" EXACT [] is_a: GO:0031379 ! RNA-directed RNA polymerase complex intersection_of: GO:0031379 ! RNA-directed RNA polymerase complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031381 name: viral RNA-directed RNA polymerase complex namespace: cellular_component def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] is_a: GO:0031379 ! RNA-directed RNA polymerase complex [Term] id: GO:0031382 name: mating projection formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532] synonym: "mating projection assembly" EXACT [] synonym: "mating projection biogenesis" RELATED [GOC:mah] synonym: "shmooing" NARROW [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion [Term] id: GO:0031383 name: regulation of mating projection assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532] synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1905708 ! regulation of cell morphogenesis involved in conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031382 ! mating projection formation relationship: regulates GO:0031382 ! mating projection formation [Term] id: GO:0031384 name: regulation of initiation of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031385 name: regulation of termination of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031386 name: protein tag namespace: molecular_function def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, GOC:go_curators, PMID:19028679, PMID:20054389, PMID:6305978] comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures. subset: goslim_pir synonym: "covalent modifier" RELATED [GOC:vw] synonym: "protein tagging activity" RELATED [] synonym: "ubiquitin" RELATED [] synonym: "ubiquitin-like protein modifier" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0031387 name: MPF complex namespace: cellular_component def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0031388 name: organic acid phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0031389 name: Rad17 RFC-like complex namespace: cellular_component def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Rad17-RFC" EXACT [] synonym: "Rad17-RLC" EXACT [] synonym: "Rad24p RFC-like complex" EXACT [] synonym: "RFC (Rad17)" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0031390 name: Ctf18 RFC-like complex namespace: cellular_component def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] synonym: "Ctf18-RFC" EXACT [] synonym: "Ctf18-RLC" EXACT [] synonym: "RFC (Ctf18)" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0031391 name: Elg1 RFC-like complex namespace: cellular_component def: "A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980] synonym: "Elg1-RFC" EXACT [] synonym: "Elg1-RLC" EXACT [] synonym: "RFC (Elg1)" EXACT [] is_a: GO:1904949 ! ATPase complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0031392 name: regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "regulation of prostaglandin anabolism" EXACT [] synonym: "regulation of prostaglandin biosynthesis" EXACT [] synonym: "regulation of prostaglandin formation" EXACT [] synonym: "regulation of prostaglandin synthesis" EXACT [] is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001516 ! prostaglandin biosynthetic process relationship: regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031393 name: negative regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "down regulation of prostaglandin biosynthetic process" EXACT [] synonym: "down-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "downregulation of prostaglandin biosynthetic process" EXACT [] synonym: "inhibition of prostaglandin biosynthetic process" NARROW [] synonym: "negative regulation of prostaglandin anabolism" EXACT [] synonym: "negative regulation of prostaglandin biosynthesis" EXACT [] synonym: "negative regulation of prostaglandin formation" EXACT [] synonym: "negative regulation of prostaglandin synthesis" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031394 name: positive regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "activation of prostaglandin biosynthetic process" NARROW [] synonym: "positive regulation of prostaglandin anabolism" EXACT [] synonym: "positive regulation of prostaglandin biosynthesis" EXACT [] synonym: "positive regulation of prostaglandin formation" EXACT [] synonym: "positive regulation of prostaglandin synthesis" EXACT [] synonym: "stimulation of prostaglandin biosynthetic process" NARROW [] synonym: "up regulation of prostaglandin biosynthetic process" EXACT [] synonym: "up-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "upregulation of prostaglandin biosynthetic process" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001516 ! prostaglandin biosynthetic process relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031395 name: bursicon neuropeptide hormone complex namespace: cellular_component def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0031396 name: regulation of protein ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016567 ! protein ubiquitination relationship: regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031397 name: negative regulation of protein ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "down regulation of protein ubiquitination" EXACT [] synonym: "down-regulation of protein ubiquitination" EXACT [] synonym: "downregulation of protein ubiquitination" EXACT [] synonym: "inhibition of protein ubiquitination" NARROW [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016567 ! protein ubiquitination relationship: negatively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031398 name: positive regulation of protein ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "activation of protein ubiquitination" NARROW [] synonym: "stimulation of protein ubiquitination" NARROW [] synonym: "up regulation of protein ubiquitination" EXACT [] synonym: "up-regulation of protein ubiquitination" EXACT [] synonym: "upregulation of protein ubiquitination" EXACT [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016567 ! protein ubiquitination relationship: positively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006464 ! cellular protein modification process relationship: regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process relationship: negatively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006464 ! cellular protein modification process relationship: positively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031402 name: sodium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with sodium ions (Na+)." [GOC:mah] xref: MIPS_funcat:16.17.05 is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031403 name: lithium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lithium ions (Li+)." [GOC:mah] is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031404 name: chloride ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with chloride ions (Cl-)." [GOC:mah] synonym: "chloride binding" EXACT [] is_a: GO:0043168 ! anion binding [Term] id: GO:0031405 name: lipoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] subset: goslim_pir is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding [Term] id: GO:0031407 name: oxylipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] synonym: "oxylipin metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0031408 name: oxylipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] synonym: "oxylipin anabolism" EXACT [] synonym: "oxylipin biosynthesis" EXACT [] synonym: "oxylipin formation" EXACT [] synonym: "oxylipin synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0031407 ! oxylipin metabolic process [Term] id: GO:0031409 name: pigment binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031411 name: gas vesicle namespace: cellular_component def: "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations." [PMID:22147705, PMID:8177173] comment: Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane. synonym: "gas vacuole" RELATED [GOC:pr] xref: MIPS_funcat:70.36.05 is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031412 name: gas vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah] comment: Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane. synonym: "gas vesicle biosynthesis" NARROW [GOC:mah] synonym: "gas vesicle formation" NARROW [GOC:mah] synonym: "gas vesicle organisation" EXACT [] synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0031413 name: regulation of buoyancy namespace: biological_process def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420] synonym: "buoyancy regulation" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031414 name: N-terminal protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] synonym: "NAT complex" EXACT [] is_a: GO:0031248 ! protein acetyltransferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031415 name: NatA complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] synonym: "N-terminal acetyltransferase A complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031416 name: NatB complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] synonym: "N-terminal acetyltransferase B complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031417 name: NatC complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] synonym: "N-terminal acetyltransferase C complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031418 name: L-ascorbic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah] synonym: "L-ascorbate binding" EXACT [] synonym: "vitamin C binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0048029 ! monosaccharide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0031419 name: cobalamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] synonym: "vitamin B12 binding" EXACT [] xref: MIPS_funcat:16.21.09 is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0031420 name: alkali metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0031421 name: invertasome namespace: cellular_component def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] is_a: GO:0032993 ! protein-DNA complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031422 name: RecQ family helicase-topoisomerase III complex namespace: cellular_component def: "A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139] synonym: "RecQ helicase-Topo III complex" EXACT [PMID:15889139] synonym: "Sgs1-Top3 complex" NARROW [PMID:15889139] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0031423 name: hexon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] is_a: GO:0005515 ! protein binding [Term] id: GO:0031424 name: keratinization namespace: biological_process def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0031425 name: chloroplast RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031426 name: polycistronic mRNA processing namespace: biological_process def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah] is_a: GO:0006397 ! mRNA processing [Term] id: GO:0031427 name: response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0031428 name: box C/D snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs." [ISBN:0879695897, PMID:17284456] synonym: "box C/D small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm] synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456] synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" EXACT [PMID:17284456] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0031429 name: box H/ACA snoRNP complex namespace: cellular_component def: "A box H/ACA RNP complex that is located in the nucleolus." [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365] synonym: "box H/ACA small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm] synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456] is_a: GO:0072588 ! box H/ACA RNP complex is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0031430 name: M band namespace: cellular_component def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] synonym: "M disc" EXACT [] synonym: "M line" NARROW [] synonym: "mesophragma" EXACT [] synonym: "midline" BROAD [] xref: Wikipedia:Sarcomere#bands is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031672 ! A band [Term] id: GO:0031431 name: Dbf4-dependent protein kinase complex namespace: cellular_component def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] synonym: "Cdc7-Dbf4 complex" NARROW [] synonym: "DDK" EXACT [] synonym: "Hsk1-Dfp1 kinase complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031432 name: titin binding namespace: molecular_function def: "Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031433 name: telethonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031434 name: mitogen-activated protein kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah] synonym: "MAPKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031435 name: mitogen-activated protein kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] synonym: "MAPKKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031436 name: BRCA1-BARD1 complex namespace: cellular_component def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0031437 name: regulation of mRNA cleavage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006379 ! mRNA cleavage relationship: regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031438 name: negative regulation of mRNA cleavage namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "down regulation of mRNA cleavage" EXACT [] synonym: "down-regulation of mRNA cleavage" EXACT [] synonym: "downregulation of mRNA cleavage" EXACT [] synonym: "inhibition of mRNA cleavage" NARROW [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:1903312 ! negative regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006379 ! mRNA cleavage relationship: negatively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031439 name: positive regulation of mRNA cleavage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "activation of mRNA cleavage" NARROW [] synonym: "stimulation of mRNA cleavage" NARROW [] synonym: "up regulation of mRNA cleavage" EXACT [] synonym: "up-regulation of mRNA cleavage" EXACT [] synonym: "upregulation of mRNA cleavage" EXACT [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:1903313 ! positive regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006379 ! mRNA cleavage relationship: positively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031440 name: regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] is_a: GO:0050684 ! regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031124 ! mRNA 3'-end processing relationship: regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031441 name: negative regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "down regulation of mRNA 3'-end processing" EXACT [] synonym: "down-regulation of mRNA 3'-end processing" EXACT [] synonym: "downregulation of mRNA 3'-end processing" EXACT [] synonym: "inhibition of mRNA 3'-end processing" NARROW [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050686 ! negative regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031124 ! mRNA 3'-end processing relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031442 name: positive regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "activation of mRNA 3'-end processing" NARROW [] synonym: "stimulation of mRNA 3'-end processing" NARROW [] synonym: "up regulation of mRNA 3'-end processing" EXACT [] synonym: "up-regulation of mRNA 3'-end processing" EXACT [] synonym: "upregulation of mRNA 3'-end processing" EXACT [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050685 ! positive regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031124 ! mRNA 3'-end processing relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031443 name: fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "fast-twitch skeletal fiber contraction" EXACT [] synonym: "fast-twitch skeletal fibre contraction" EXACT [] synonym: "fast-twitch skeletal muscle fibre contraction" EXACT [] synonym: "fast-twitch skeletal myofiber contraction" EXACT [] synonym: "fast-twitch skeletal myofibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031444 name: slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "slow-twitch skeletal muscle fibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031445 name: regulation of heterochromatin assembly namespace: biological_process def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of heterochromatin formation" EXACT [] is_a: GO:0010847 ! regulation of chromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031507 ! heterochromatin assembly relationship: regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031446 name: regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031447 name: negative regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031448 name: positive regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031449 name: regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031450 name: negative regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031451 name: positive regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031452 name: negative regulation of heterochromatin assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "down regulation of heterochromatin formation" EXACT [] synonym: "down-regulation of heterochromatin formation" EXACT [] synonym: "downregulation of heterochromatin formation" EXACT [] synonym: "inhibition of heterochromatin formation" NARROW [] synonym: "negative regulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin assembly is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031507 ! heterochromatin assembly relationship: negatively_regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031453 name: positive regulation of heterochromatin assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "activation of heterochromatin formation" NARROW [] synonym: "positive regulation of heterochromatin formation" EXACT [] synonym: "stimulation of heterochromatin formation" NARROW [] synonym: "up regulation of heterochromatin formation" EXACT [] synonym: "up-regulation of heterochromatin formation" EXACT [] synonym: "upregulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031507 ! heterochromatin assembly relationship: positively_regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031454 name: regulation of extent of heterochromatin assembly namespace: biological_process def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of extent of heterochromatin formation" EXACT [] synonym: "regulation of heterochromatin spreading" RELATED [] is_a: GO:0031445 ! regulation of heterochromatin assembly [Term] id: GO:0031455 name: glycine betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine metabolism" EXACT [] synonym: "N-trimethylglycine metabolic process" EXACT [] synonym: "N-trimethylglycine metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0031456 name: glycine betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine anabolism" EXACT [] synonym: "glycine betaine biosynthesis" EXACT [] synonym: "glycine betaine formation" EXACT [] synonym: "glycine betaine synthesis" EXACT [] synonym: "N-trimethylglycine biosynthesis" EXACT [] synonym: "N-trimethylglycine biosynthetic process" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0031455 ! glycine betaine metabolic process [Term] id: GO:0031457 name: glycine betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine breakdown" EXACT [] synonym: "glycine betaine catabolism" EXACT [] synonym: "glycine betaine degradation" EXACT [] synonym: "N-trimethylglycine catabolic process" EXACT [] synonym: "N-trimethylglycine catabolism" EXACT [] is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0031455 ! glycine betaine metabolic process [Term] id: GO:0031458 name: ATPase-coupled betaine transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] synonym: "ATP-dependent betaine transporter activity" EXACT [] synonym: "betaine ABC transporter" NARROW [] synonym: "betaine-transporting ATPase activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0031459 name: ATPase-coupled glycine betaine transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg] synonym: "ATP-dependent glycine betaine transporter activity" EXACT [] synonym: "glycine betaine ABC transporter" NARROW [] synonym: "glycine betaine-transporting ATPase activity" EXACT [] synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] xref: RHEA:32783 is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity is_a: GO:0015418 ! ATPase-coupled quaternary ammonium compound transmembrane transporting activity relationship: part_of GO:0031460 ! glycine betaine transport [Term] id: GO:0031460 name: glycine betaine transport namespace: biological_process def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "N-trimethylglycine transport" EXACT [] is_a: GO:0015838 ! amino-acid betaine transport [Term] id: GO:0031461 name: cullin-RING ubiquitin ligase complex namespace: cellular_component def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] synonym: "CRL complex" EXACT [] synonym: "cullin complex" EXACT [] synonym: "cullin-RING ligase" RELATED [] is_a: GO:0000151 ! ubiquitin ligase complex [Term] id: GO:0031462 name: Cul2-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CBC complex" BROAD [] synonym: "CDL2 complex" EXACT [] synonym: "CRL2 complex" EXACT [] synonym: "cullin-RING ligase 2" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "ECS complex" BROAD [] synonym: "SCF2 complex" RELATED [] synonym: "VBC complex" NARROW [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031463 name: Cul3-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] synonym: "BC3B complex" EXACT [] synonym: "BCR3 complex" EXACT [] synonym: "CDL3 complex" EXACT [] synonym: "CRL3 complex" EXACT [] synonym: "cullin-RING ligase 3" EXACT [] synonym: "SCF3 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031464 name: Cul4A-RING E3 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] synonym: "CDL4 complex" EXACT [] synonym: "CRL4 complex" EXACT [] synonym: "cullin-RING ligase 4A" EXACT [] synonym: "DCX complex" EXACT [] synonym: "SCF4 complex" RELATED [] synonym: "VDC complex" NARROW [] is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex [Term] id: GO:0031465 name: Cul4B-RING E3 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] synonym: "cullin-RING ligase 4B" EXACT [] is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex [Term] id: GO:0031466 name: Cul5-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CDL5 complex" EXACT [] synonym: "CRL5 complex" EXACT [] synonym: "cullin-RING ligase 5" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "SCF5 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031467 name: Cul7-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] synonym: "CDL7 complex" EXACT [] synonym: "CRL7 complex" EXACT [] synonym: "cullin-RING ligase 7" EXACT [] synonym: "SCF7 complex" EXACT [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031468 name: nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah] is_a: GO:0006998 ! nuclear envelope organization [Term] id: GO:0031469 name: polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: goslim_pir is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031470 name: carboxysome namespace: cellular_component def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] xref: MIPS_funcat:70.36.03 xref: Wikipedia:Carboxysome is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031471 name: ethanolamine degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] synonym: "ethanolamine metabolosome" RELATED [] is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031472 name: propanediol degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031473 name: myosin III binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031474 name: myosin IV complex namespace: cellular_component def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [Wikipedia:Myosin] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031475 name: myosin V complex namespace: cellular_component def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [Wikipedia:Myosin] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031476 name: myosin VI complex namespace: cellular_component def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031477 name: myosin VII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031478 name: myosin VIII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031479 name: myosin IX complex namespace: cellular_component def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031480 name: myosin X complex namespace: cellular_component def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031481 name: myosin XI complex namespace: cellular_component def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031482 name: myosin XII complex namespace: cellular_component def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031483 name: myosin XIII complex namespace: cellular_component def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031484 name: myosin XIV complex namespace: cellular_component def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031485 name: myosin XV complex namespace: cellular_component def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031486 name: myosin XVI complex namespace: cellular_component def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031487 name: myosin XVII complex namespace: cellular_component def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031488 name: myosin XVIII complex namespace: cellular_component def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031489 name: myosin V binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031490 name: chromatin DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] is_a: GO:0003677 ! DNA binding is_a: GO:0003682 ! chromatin binding [Term] id: GO:0031491 name: nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] is_a: GO:0003682 ! chromatin binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0031492 name: nucleosomal DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA portion of a nucleosome." [GOC:mah] is_a: GO:0031490 ! chromatin DNA binding is_a: GO:0031491 ! nucleosome binding [Term] id: GO:0031493 name: nucleosomal histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [GOC:mah] is_a: GO:0031491 ! nucleosome binding is_a: GO:0042393 ! histone binding [Term] id: GO:0031494 name: regulation of mating type switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007533 ! mating type switching relationship: regulates GO:0007533 ! mating type switching [Term] id: GO:0031495 name: negative regulation of mating type switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "down regulation of mating type switching" EXACT [] synonym: "down-regulation of mating type switching" EXACT [] synonym: "downregulation of mating type switching" EXACT [] synonym: "inhibition of mating type switching" NARROW [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007533 ! mating type switching relationship: negatively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031496 name: positive regulation of mating type switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "activation of mating type switching" NARROW [] synonym: "stimulation of mating type switching" NARROW [] synonym: "up regulation of mating type switching" EXACT [] synonym: "up-regulation of mating type switching" EXACT [] synonym: "upregulation of mating type switching" EXACT [] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007533 ! mating type switching relationship: positively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031497 name: chromatin assembly namespace: biological_process def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0006323 ! DNA packaging [Term] id: GO:0031498 name: chromatin disassembly namespace: biological_process def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0022411 ! cellular component disassembly [Term] id: GO:0031499 name: TRAMP complex namespace: cellular_component def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137] synonym: "TRAMP4 complex" NARROW [] synonym: "TRAMP5 complex" NARROW [] synonym: "Trf4 complex" NARROW [] synonym: "Trf4 poly(A) polymerase complex" NARROW [] synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW [] xref: Wikipedia:TRAMP_complex is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031500 name: Tea1 cell-end complex namespace: cellular_component def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0000133 ! polarisome [Term] id: GO:0031501 name: mannosyltransferase complex namespace: cellular_component def: "A complex that posseses mannosyltransferase activity." [GOC:mah] subset: goslim_pir is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031502 name: dolichyl-phosphate-mannose-protein mannosyltransferase complex namespace: cellular_component def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, GOC:pr, PMID:15948957] comment: Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. synonym: "PMT family mannosyltransferase complex" RELATED [] synonym: "protein O-mannosyltransferase complex" EXACT [] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0008104 ! protein localization [Term] id: GO:0031504 name: peptidoglycan-based cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] synonym: "peptidoglycan-based cell wall organisation" EXACT [GOC:mah] synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071555 ! cell wall organization [Term] id: GO:0031505 name: fungal-type cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW [] synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] synonym: "fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0071555 ! cell wall organization is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0031506 name: cell wall glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah] synonym: "cell wall glycoprotein anabolism" EXACT [] synonym: "cell wall glycoprotein biosynthesis" EXACT [] synonym: "cell wall glycoprotein formation" EXACT [] synonym: "cell wall glycoprotein synthesis" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process [Term] id: GO:0031507 name: heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] synonym: "heterochromatin formation" EXACT [] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0031497 ! chromatin assembly is_a: GO:0070828 ! heterochromatin organization [Term] id: GO:0031508 name: pericentric heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156] synonym: "centric heterochromatin formation" RELATED [] synonym: "centromeric heterochromatin biosynthesis" EXACT [] synonym: "centromeric heterochromatin formation" EXACT [] is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0031507 ! heterochromatin assembly relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0031509 name: telomeric heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah] synonym: "telomeric heterochromatin formation" EXACT [] is_a: GO:0031507 ! heterochromatin assembly relationship: part_of GO:0032200 ! telomere organization [Term] id: GO:0031510 name: SUMO activating enzyme complex namespace: cellular_component def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] synonym: "SAE" EXACT [] synonym: "SUMO E1 activator enzyme complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031511 name: Mis6-Sim4 complex namespace: cellular_component def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] synonym: "Mis6 centromere subcomplex" NARROW [] synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296] synonym: "Sim4 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000939 ! condensed chromosome inner kinetochore [Term] id: GO:0031514 name: motile cilium namespace: cellular_component alt_id: GO:0009434 alt_id: GO:0031512 def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "microtubule-based flagellum" RELATED [] synonym: "motile cilia" EXACT [] synonym: "motile primary cilia" RELATED [] synonym: "motile primary cilium" RELATED [] synonym: "motile secondary cilium" RELATED [] synonym: "nodal cilium" RELATED [] is_a: GO:0005929 ! cilium [Term] id: GO:0031515 name: tRNA (m1A) methyltransferase complex namespace: cellular_component def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] is_a: GO:0043527 ! tRNA methyltransferase complex [Term] id: GO:0031516 name: far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity relationship: part_of GO:0010018 ! far-red light signaling pathway [Term] id: GO:0031517 name: red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity relationship: part_of GO:0010161 ! red light signaling pathway [Term] id: GO:0031518 name: CBF3 complex namespace: cellular_component def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0031519 name: PcG protein complex namespace: cellular_component def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] subset: goslim_pir synonym: "Polycomb Group protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031520 name: plasma membrane of cell tip namespace: cellular_component def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] synonym: "'plasma membrane, cell tip'" EXACT [] is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0051286 ! cell tip relationship: part_of GO:0051286 ! cell tip [Term] id: GO:0031521 name: spitzenkorper namespace: cellular_component def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0001411 ! hyphal tip relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0031522 name: cell envelope Sec protein transport complex namespace: cellular_component def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. synonym: "plasma membrane Sec complex" RELATED [] synonym: "Sec complex" BROAD [] synonym: "Sec secretion complex" NARROW [] synonym: "Sec translocation complex" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0031523 name: Myb complex namespace: cellular_component def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0031524 name: menthol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] synonym: "menthol metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0031525 name: menthol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] synonym: "menthol anabolism" EXACT [] synonym: "menthol biosynthesis" EXACT [] synonym: "menthol formation" EXACT [] synonym: "menthol synthesis" EXACT [] is_a: GO:0016099 ! monoterpenoid biosynthetic process is_a: GO:0031524 ! menthol metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0031526 name: brush border membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005903 ! brush border [Term] id: GO:0031527 name: filopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0031528 name: microvillus membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005902 ! microvillus [Term] id: GO:0031529 name: ruffle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] synonym: "ruffle organisation" EXACT [GOC:mah] synonym: "ruffle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0031530 name: gonadotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [GOC:pr, PMID:15196882] synonym: "GnRH receptor binding" EXACT [] synonym: "gonadotrophin-releasing hormone receptor binding" EXACT [GOC:dph] is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031531 name: thyrotropin-releasing hormone receptor binding namespace: molecular_function alt_id: GO:0031888 def: "Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] synonym: "thyrotropin releasing hormone receptor binding" EXACT [] synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031532 name: actin cytoskeleton reorganization namespace: biological_process alt_id: GO:0007012 def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] synonym: "actin cytoskeleton remodeling" EXACT [] synonym: "actin cytoskeleton reorganisation" EXACT [] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031533 name: mRNA cap methyltransferase complex namespace: cellular_component def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] synonym: "mRNA capping enzyme complex" EXACT [GOC:vw] is_a: GO:0034708 ! methyltransferase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031534 name: minus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031535 name: plus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031536 name: positive regulation of exit from mitosis namespace: biological_process def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] synonym: "activation of exit from mitosis" NARROW [] synonym: "stimulation of exit from mitosis" NARROW [] synonym: "up regulation of exit from mitosis" EXACT [] synonym: "up-regulation of exit from mitosis" EXACT [] synonym: "upregulation of exit from mitosis" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010458 ! exit from mitosis relationship: positively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0031537 name: regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046283 ! anthocyanin-containing compound metabolic process relationship: regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031538 name: negative regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin metabolic process" EXACT [] synonym: "down-regulation of anthocyanin metabolic process" EXACT [] synonym: "downregulation of anthocyanin metabolic process" EXACT [] synonym: "inhibition of anthocyanin metabolic process" NARROW [] synonym: "negative regulation of anthocyanin metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process relationship: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031539 name: positive regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "activation of anthocyanin metabolic process" NARROW [] synonym: "positive regulation of anthocyanin metabolism" EXACT [] synonym: "stimulation of anthocyanin metabolic process" NARROW [] synonym: "up regulation of anthocyanin metabolic process" EXACT [] synonym: "up-regulation of anthocyanin metabolic process" EXACT [] synonym: "upregulation of anthocyanin metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process relationship: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031540 name: regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin anabolism" EXACT [] synonym: "regulation of anthocyanin biosynthesis" EXACT [] synonym: "regulation of anthocyanin formation" EXACT [] synonym: "regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process relationship: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031541 name: negative regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin biosynthetic process" EXACT [] synonym: "down-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "downregulation of anthocyanin biosynthetic process" EXACT [] synonym: "inhibition of anthocyanin biosynthetic process" NARROW [] synonym: "negative regulation of anthocyanin anabolism" EXACT [] synonym: "negative regulation of anthocyanin biosynthesis" EXACT [] synonym: "negative regulation of anthocyanin formation" EXACT [] synonym: "negative regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process relationship: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031542 name: positive regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "activation of anthocyanin biosynthetic process" NARROW [] synonym: "positive regulation of anthocyanin anabolism" EXACT [] synonym: "positive regulation of anthocyanin biosynthesis" EXACT [] synonym: "positive regulation of anthocyanin formation" EXACT [] synonym: "positive regulation of anthocyanin synthesis" EXACT [] synonym: "stimulation of anthocyanin biosynthetic process" NARROW [] synonym: "up regulation of anthocyanin biosynthetic process" EXACT [] synonym: "up-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "upregulation of anthocyanin biosynthetic process" EXACT [] is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process relationship: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031543 name: peptidyl-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462] synonym: "proline hydroxylase activity" BROAD [GOC:krc, GOC:pr] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [GOC:krc, GOC:pr] synonym: "prolyl 4-hydroxylase activity" BROAD [GOC:krc, GOC:pr] synonym: "prolyl hydroxylase activity" BROAD [GOC:krc, GOC:pr] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0031544 name: peptidyl-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031545 name: peptidyl-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] synonym: "prolyl 4-hydroxylase" BROAD [] xref: Reactome:R-HSA-1234165 "Nuclear PHD1,3 hydroxylates proline residues on HIF3A" xref: Reactome:R-HSA-1234166 "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)" xref: Reactome:R-HSA-1234173 "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A" xref: Reactome:R-HSA-1234177 "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A" xref: Reactome:R-HSA-1234179 "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)" xref: Reactome:R-HSA-1234181 "Nuclear PHD1,3 hydroxylates proline residues on HIF1A" is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031546 name: brain-derived neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor." [GOC:mah] synonym: "BDNF receptor binding" EXACT [] synonym: "brain-derived neurotrophic factor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0031547 name: brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] synonym: "BDNF receptor signaling pathway" EXACT [] synonym: "BDNF signalling pathway" EXACT [] synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0031548 name: regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "regulation of BDNF receptor signaling pathway" EXACT [] synonym: "regulation of BDNF receptor signalling pathway" EXACT [] synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031549 name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "negative regulation of BDNF receptor signaling pathway" EXACT [] synonym: "negative regulation of BDNF receptor signalling pathway" EXACT [] synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031550 name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "positive regulation of BDNF receptor signaling pathway" EXACT [] synonym: "positive regulation of BDNF receptor signalling pathway" EXACT [] synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031551 name: regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "regulation of BDNF receptor activity" EXACT [] synonym: "regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity relationship: regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity [Term] id: GO:0031552 name: negative regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "negative regulation of BDNF receptor activity" EXACT [] synonym: "negative regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity relationship: negatively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity [Term] id: GO:0031553 name: positive regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "positive regulation of BDNF receptor activity" EXACT [] synonym: "positive regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT [] is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity relationship: positively_regulates GO:0060175 ! brain-derived neurotrophic factor-activated receptor activity [Term] id: GO:0031554 name: regulation of DNA-templated transcription, termination namespace: biological_process def: "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH] synonym: "regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] synonym: "transcription antiterminator activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006353 ! DNA-templated transcription, termination relationship: regulates GO:0006353 ! DNA-templated transcription, termination [Term] id: GO:0031555 name: transcriptional attenuation namespace: biological_process def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682] xref: Wikipedia:Attenuator_(genetics) is_a: GO:0031554 ! regulation of DNA-templated transcription, termination [Term] id: GO:0031556 name: transcriptional attenuation by ribosome namespace: biological_process def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682] synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031555 ! transcriptional attenuation [Term] id: GO:0031557 name: obsolete induction of programmed cell death in response to chemical stimulus namespace: biological_process def: "OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0012501 programmed cell death. synonym: "induction of programmed cell death in response to chemical stimulus" EXACT [] synonym: "induction of programmed cell death in response to chemical substance" EXACT [] is_obsolete: true [Term] id: GO:0031558 name: obsolete induction of apoptosis in response to chemical stimulus namespace: biological_process def: "OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0006915 apoptotic process. synonym: "induction of apoptosis in response to chemical stimulus" EXACT [] synonym: "induction of apoptosis in response to chemical substance" EXACT [] is_obsolete: true [Term] id: GO:0031559 name: oxidosqualene cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct] comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah] is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0031560 name: cellular bud neck polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] is_a: GO:0000133 ! polarisome intersection_of: GO:0000133 ! polarisome intersection_of: part_of GO:0005935 ! cellular bud neck relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0031561 name: cellular bud tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] is_a: GO:0000133 ! polarisome intersection_of: GO:0000133 ! polarisome intersection_of: part_of GO:0005934 ! cellular bud tip relationship: part_of GO:0005934 ! cellular bud tip [Term] id: GO:0031562 name: hyphal tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] is_a: GO:0000133 ! polarisome intersection_of: GO:0000133 ! polarisome intersection_of: part_of GO:0001411 ! hyphal tip relationship: part_of GO:0001411 ! hyphal tip [Term] id: GO:0031563 name: mating projection tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] is_a: GO:0000133 ! polarisome intersection_of: GO:0000133 ! polarisome intersection_of: part_of GO:0043332 ! mating projection tip relationship: part_of GO:0043332 ! mating projection tip [Term] id: GO:0031564 name: transcription antitermination namespace: biological_process def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s)." [ISBN:0198577788, PMID:12456320] synonym: "transcriptional readthrough" EXACT [] is_a: GO:0031554 ! regulation of DNA-templated transcription, termination [Term] id: GO:0031565 name: obsolete cytokinesis checkpoint namespace: biological_process alt_id: GO:0000135 def: "OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition." [GOC:mtg_cell_cycle] comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. synonym: "contractile ring checkpoint" EXACT [] synonym: "septin checkpoint" EXACT [] is_obsolete: true consider: GO:0044878 consider: GO:0044879 [Term] id: GO:0031566 name: actomyosin contractile ring maintenance namespace: biological_process def: "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] synonym: "contractile ring maintenance involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0036212 ! contractile ring maintenance is_a: GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0031567 name: mitotic cell size control checkpoint namespace: biological_process def: "The mitotic cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] is_a: GO:0007093 ! mitotic cell cycle checkpoint intersection_of: GO:0007093 ! mitotic cell cycle checkpoint intersection_of: part_of GO:0008361 ! regulation of cell size relationship: part_of GO:0008361 ! regulation of cell size [Term] id: GO:0031568 name: G1 cell size control checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G1 and S phase until a critical size is reached." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition size control checkpoint" EXACT [] synonym: "mitotic G1 cell size control checkpoint" EXACT [] is_a: GO:0031567 ! mitotic cell size control checkpoint is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0031567 ! mitotic cell size control checkpoint intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0031569 name: mitotic G2 cell size control checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G2 and M phase until a critical size is reached." [GOC:mtg_cell_cycle] synonym: "G2 cell size control checkpoint" EXACT [] synonym: "G2/M transition size control checkpoint" EXACT [] synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle is_a: GO:0031567 ! mitotic cell size control checkpoint intersection_of: GO:0031567 ! mitotic cell size control checkpoint intersection_of: happens_during GO:0051319 ! G2 phase intersection_of: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: happens_during GO:0051319 ! G2 phase [Term] id: GO:0031570 name: DNA integrity checkpoint namespace: biological_process def: "A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031571 name: mitotic G1 DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] is_a: GO:0044773 ! mitotic DNA damage checkpoint is_a: GO:0044783 ! G1 DNA damage checkpoint is_a: GO:0044819 ! mitotic G1/S transition checkpoint intersection_of: GO:0044783 ! G1 DNA damage checkpoint intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0031572 name: G2 DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] comment: Note that this term should only be used as a grouping term for the mitotic and meiotic G2 DNA damage checkpoints, and should not be used for direct manual annotation. You should always be able to choose one of its child terms instead. subset: gocheck_do_not_manually_annotate synonym: "G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0000077 ! DNA damage checkpoint [Term] id: GO:0031573 name: intra-S DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw] synonym: "mitotic intra-S DNA damage checkpoint" EXACT [] synonym: "S-phase checkpoint" BROAD [] is_a: GO:0044773 ! mitotic DNA damage checkpoint [Term] id: GO:0031577 name: spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term. subset: gocheck_do_not_manually_annotate xref: Wikipedia:Spindle_checkpoint is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031578 name: mitotic spindle orientation checkpoint namespace: biological_process def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected." [GOC:mtg_cell_cycle, PMID:14616062] synonym: "mitotic cell cycle spindle orientation checkpoint" EXACT [] synonym: "SOC" EXACT [] synonym: "spindle position checkpoint" EXACT [] synonym: "SPOC" EXACT [] is_a: GO:0001100 ! negative regulation of exit from mitosis is_a: GO:0071174 ! mitotic spindle checkpoint [Term] id: GO:0031579 name: membrane raft organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah] synonym: "lipid raft organization" EXACT [GOC:mah] synonym: "membrane raft organisation" EXACT [GOC:mah] synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization [Term] id: GO:0031580 name: membrane raft distribution namespace: biological_process def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah] synonym: "lipid raft distribution" EXACT [] is_a: GO:0031579 ! membrane raft organization is_a: GO:0051665 ! membrane raft localization [Term] id: GO:0031581 name: hemidesmosome assembly namespace: biological_process def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403] is_a: GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0031582 name: replication fork arrest at rDNA repeats namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] synonym: "replication fork blocking at rDNA repeats" EXACT [] is_a: GO:0043007 ! maintenance of rDNA is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0031583 name: phospholipase D-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA)." [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation. synonym: "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] synonym: "G-protein signalling, phospholipase D activating pathway" EXACT [] synonym: "phospholipase D-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: has_part GO:0031584 ! activation of phospholipase D activity [Term] id: GO:0031584 name: activation of phospholipase D activity namespace: biological_process def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity [Term] id: GO:0031585 name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling] synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity relationship: regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [Term] id: GO:0031586 name: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "down regulation of IP3 receptor activity" EXACT [] synonym: "down-regulation of IP3 receptor activity" EXACT [] synonym: "downregulation of IP3 receptor activity" EXACT [] synonym: "inhibition of IP3 receptor activity" NARROW [] synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling] synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph] is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity relationship: negatively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [Term] id: GO:0031587 name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "activation of IP3 receptor activity" NARROW [] synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf] synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph] synonym: "stimulation of IP3 receptor activity" NARROW [] synonym: "up regulation of IP3 receptor activity" EXACT [] synonym: "up-regulation of IP3 receptor activity" EXACT [] synonym: "upregulation of IP3 receptor activity" EXACT [] is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity relationship: positively_regulates GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [Term] id: GO:0031588 name: nucleotide-activated protein kinase complex namespace: cellular_component def: "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw] synonym: "5'-AMP-activated protein kinase complex" NARROW [] synonym: "ADP-activated protein kinase complex" NARROW [] synonym: "AMP-activated protein kinase complex" NARROW [] synonym: "AMPK complex" RELATED [] synonym: "Snf1 kinase complex" NARROW [] synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] synonym: "SNF1/AMPK protein kinase complex" NARROW [] is_a: GO:1902911 ! protein kinase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0031589 name: cell-substrate adhesion namespace: biological_process def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] is_a: GO:0007155 ! cell adhesion [Term] id: GO:0031590 name: wybutosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037] synonym: "wybutosine metabolism" EXACT [] synonym: "yW metabolic process" EXACT [] synonym: "yW metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0031591 name: wybutosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037] comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. synonym: "yW biosynthesis" EXACT [] synonym: "yW biosynthetic process" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0031590 ! wybutosine metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0031592 name: centrosomal corona namespace: cellular_component def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0031593 name: polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein." [GOC:pg] is_a: GO:0140030 ! modification-dependent protein binding [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] synonym: "NMJ" RELATED [GOC:ha] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse [Term] id: GO:0031595 name: nuclear proteasome complex namespace: cellular_component def: "A proteasome found in the nucleus of a cell." [GOC:mah] is_a: GO:0000502 ! proteasome complex intersection_of: GO:0000502 ! proteasome complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0031596 name: obsolete ER proteasome complex namespace: cellular_component def: "OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031597 name: cytosolic proteasome complex namespace: cellular_component def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0000502 ! proteasome complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0031598 name: nuclear proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005838 ! proteasome regulatory particle intersection_of: GO:0005838 ! proteasome regulatory particle intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031599 name: obsolete ER proteasome regulatory particle namespace: cellular_component def: "OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031600 name: cytosolic proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005838 ! proteasome regulatory particle relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031601 name: nuclear proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005839 ! proteasome core complex intersection_of: GO:0005839 ! proteasome core complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031602 name: obsolete ER proteasome core complex namespace: cellular_component def: "OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031603 name: cytosolic proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005839 ! proteasome core complex relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031604 name: nuclear proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex intersection_of: GO:0019773 ! proteasome core complex, alpha-subunit complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031605 name: obsolete ER proteasome core complex, alpha-subunit complex namespace: cellular_component def: "OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031606 name: cytosolic proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031607 name: nuclear proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex intersection_of: GO:0019774 ! proteasome core complex, beta-subunit complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031608 name: obsolete ER proteasome core complex, beta-subunit complex namespace: cellular_component def: "OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031609 name: cytosolic proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031610 name: nuclear proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex intersection_of: GO:0008540 ! proteasome regulatory particle, base subcomplex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031611 name: obsolete ER proteasome regulatory particle, base subcomplex namespace: cellular_component def: "OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031612 name: cytosolic proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031613 name: nuclear proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex intersection_of: GO:0008541 ! proteasome regulatory particle, lid subcomplex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031614 name: obsolete ER proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031615 name: cytosolic proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031616 name: spindle pole centrosome namespace: cellular_component def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] is_a: GO:0005813 ! centrosome intersection_of: GO:0005813 ! centrosome intersection_of: part_of GO:0000922 ! spindle pole relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0031617 name: NMS complex namespace: cellular_component def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] synonym: "KMN kinetochore network" EXACT [] synonym: "KNL-1-Mis12-Ndc80" EXACT [] synonym: "Ndc80-MIND-Spc7 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000776 ! kinetochore [Term] id: GO:0031618 name: nuclear pericentric heterochromatin namespace: cellular_component alt_id: GO:0002137 def: "Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993] synonym: "nuclear centric heterochromatin" EXACT [] synonym: "nuclear cluster" NARROW [] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0005721 ! pericentric heterochromatin intersection_of: GO:0005721 ! pericentric heterochromatin intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0031619 name: homologous chromosome orientation involved in meiotic metaphase I plate congression namespace: biological_process def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb] synonym: "homologous chromosome orientation during meiosis I" RELATED [] is_a: GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore relationship: part_of GO:0043060 ! meiotic metaphase I plate congression [Term] id: GO:0031620 name: regulation of fever generation namespace: biological_process def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of pyrexia" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0031650 ! regulation of heat generation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001660 ! fever generation relationship: regulates GO:0001660 ! fever generation [Term] id: GO:0031621 name: negative regulation of fever generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "down regulation of fever" EXACT [] synonym: "down-regulation of fever" EXACT [] synonym: "downregulation of fever" EXACT [] synonym: "inhibition of fever" NARROW [] synonym: "negative regulation of pyrexia" EXACT [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031651 ! negative regulation of heat generation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001660 ! fever generation relationship: negatively_regulates GO:0001660 ! fever generation [Term] id: GO:0031622 name: positive regulation of fever generation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add] synonym: "activation of fever" NARROW [] synonym: "positive regulation of pyrexia" EXACT [] synonym: "stimulation of fever" NARROW [] synonym: "up regulation of fever" EXACT [] synonym: "up-regulation of fever" EXACT [] synonym: "upregulation of fever" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031652 ! positive regulation of heat generation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001660 ! fever generation relationship: positively_regulates GO:0001660 ! fever generation [Term] id: GO:0031623 name: receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0031624 name: ubiquitin conjugating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] is_a: GO:0044390 ! ubiquitin-like protein conjugating enzyme binding [Term] id: GO:0031625 name: ubiquitin protein ligase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] synonym: "ubiquitin ligase binding" EXACT [] is_a: GO:0044389 ! ubiquitin-like protein ligase binding [Term] id: GO:0031626 name: beta-endorphin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0031627 name: telomeric loop formation namespace: biological_process def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214] synonym: "T loop biosynthesis" EXACT [] synonym: "T loop formation" EXACT [] synonym: "t-loop biosynthesis" EXACT [] synonym: "t-loop formation" EXACT [] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0031628 name: opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opioid receptor." [GOC:nln] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031629 name: synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] subset: goslim_synapse synonym: "synaptic vesicle fusion" BROAD [] synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0099500 ! vesicle fusion to plasma membrane relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0031630 name: regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] subset: goslim_synapse synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031631 name: negative regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "down regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "down-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "downregulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane" EXACT [] synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic membrane" BROAD [] synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031632 name: positive regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "positive regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "up regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "up-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031633 name: xanthophore namespace: cellular_component def: "A chromatophore containing yellow pigment." [ISBN:0395825172] comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. is_a: GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0031634 name: replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0031635 name: adenylate cyclase-inhibiting opioid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:mah] synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:0031637 name: regulation of neuronal synaptic plasticity in response to neurotrophin namespace: biological_process def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078] synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT [] is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0031638 name: zymogen activation namespace: biological_process def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] subset: goslim_chembl synonym: "zymogen activation by proteolytic cleavage" EXACT [] is_a: GO:0016485 ! protein processing [Term] id: GO:0031639 name: plasminogen activation namespace: biological_process def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] subset: goslim_chembl synonym: "cleavage of plasminogen to plasmin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0031640 name: killing of cells of other organism namespace: biological_process alt_id: GO:0001908 def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "killing of cells of another organism" EXACT [GOC:bf] synonym: "killing of cells of another, non-host, organism" NARROW [] is_a: GO:0001906 ! cell killing is_a: GO:0044364 ! disruption of cells of other organism [Term] id: GO:0031641 name: regulation of myelination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042552 ! myelination relationship: regulates GO:0042552 ! myelination [Term] id: GO:0031642 name: negative regulation of myelination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "down regulation of myelination" EXACT [] synonym: "down-regulation of myelination" EXACT [] synonym: "downregulation of myelination" EXACT [] synonym: "inhibition of myelination" NARROW [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042552 ! myelination relationship: negatively_regulates GO:0042552 ! myelination [Term] id: GO:0031643 name: positive regulation of myelination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "activation of myelination" NARROW [] synonym: "stimulation of myelination" NARROW [] synonym: "up regulation of myelination" EXACT [] synonym: "up-regulation of myelination" EXACT [] synonym: "upregulation of myelination" EXACT [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042552 ! myelination relationship: positively_regulates GO:0042552 ! myelination [Term] id: GO:0031644 name: regulation of nervous system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurological system process" EXACT [] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050877 ! nervous system process relationship: regulates GO:0050877 ! nervous system process [Term] id: GO:0031645 name: negative regulation of nervous system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurological system process" EXACT [] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050877 ! nervous system process relationship: negatively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031646 name: positive regulation of nervous system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurological system process" EXACT [] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050877 ! nervous system process relationship: positively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031647 name: regulation of protein stability namespace: biological_process def: "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031648 name: protein destabilization namespace: biological_process def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] synonym: "negative regulation of protein stability" EXACT [] synonym: "protein destabilisation" EXACT [GOC:ah] is_a: GO:0031647 ! regulation of protein stability [Term] id: GO:0031649 name: heat generation namespace: biological_process def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah] xref: MIPS_funcat:02.45.07 is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031650 name: regulation of heat generation namespace: biological_process def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031649 ! heat generation relationship: regulates GO:0031649 ! heat generation [Term] id: GO:0031651 name: negative regulation of heat generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat generation" EXACT [] synonym: "down-regulation of heat generation" EXACT [] synonym: "downregulation of heat generation" EXACT [] synonym: "inhibition of heat generation" NARROW [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031649 ! heat generation relationship: negatively_regulates GO:0031649 ! heat generation [Term] id: GO:0031652 name: positive regulation of heat generation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat generation" NARROW [] synonym: "stimulation of heat generation" NARROW [] synonym: "up regulation of heat generation" EXACT [] synonym: "up-regulation of heat generation" EXACT [] synonym: "upregulation of heat generation" EXACT [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031649 ! heat generation relationship: positively_regulates GO:0031649 ! heat generation [Term] id: GO:0031653 name: heat dissipation namespace: biological_process def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031654 name: regulation of heat dissipation namespace: biological_process def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031653 ! heat dissipation relationship: regulates GO:0031653 ! heat dissipation [Term] id: GO:0031655 name: negative regulation of heat dissipation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat dissipation" EXACT [] synonym: "down-regulation of heat dissipation" EXACT [] synonym: "downregulation of heat dissipation" EXACT [] synonym: "inhibition of heat dissipation" NARROW [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031653 ! heat dissipation relationship: negatively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031656 name: positive regulation of heat dissipation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat dissipation" NARROW [] synonym: "stimulation of heat dissipation" NARROW [] synonym: "up regulation of heat dissipation" EXACT [] synonym: "up-regulation of heat dissipation" EXACT [] synonym: "upregulation of heat dissipation" EXACT [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031653 ! heat dissipation relationship: positively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031657 name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle, GOC:pr] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031658 name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031659 name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031660 name: regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle intersection_of: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0031661 name: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] is_a: GO:0031660 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle is_a: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity intersection_of: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0031663 name: lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975] synonym: "lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "LPS-mediated signaling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide [Term] id: GO:0031664 name: regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031665 name: negative regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "negative regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031666 name: positive regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "positive regulation of LPS-mediated signaling pathway" EXACT [] synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031667 name: response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0009991 ! response to extracellular stimulus [Term] id: GO:0031668 name: cellular response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] is_a: GO:0007154 ! cell communication is_a: GO:0009991 ! response to extracellular stimulus is_a: GO:0051716 ! cellular response to stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0031669 name: cellular response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0031670 name: cellular response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] is_a: GO:0007584 ! response to nutrient is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0031671 name: primary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0140278 ! mitotic division septum assembly [Term] id: GO:0031672 name: A band namespace: cellular_component def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] synonym: "A disc" EXACT [] synonym: "anisotropic disc" EXACT [] synonym: "Q disc" EXACT [] synonym: "transverse disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031673 name: H zone namespace: cellular_component def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] synonym: "H band" EXACT [] synonym: "H disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031672 ! A band [Term] id: GO:0031674 name: I band namespace: cellular_component def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] synonym: "I disc" EXACT [] synonym: "isotropic disc" EXACT [] synonym: "J disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031676 name: plasma membrane-derived thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid membrane" EXACT [] is_a: GO:0042651 ! thylakoid membrane is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0031679 name: NADH dehydrogenase (plastoquinone) activity namespace: molecular_function alt_id: GO:0030024 def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] synonym: "NADH:plastoquinone reductase activity" EXACT [] is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0031680 name: G-protein beta/gamma-subunit complex namespace: cellular_component def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G-beta/G-gamma complex" EXACT [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031681 name: G-protein beta-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein beta subunit." [GOC:mah] synonym: "G-beta protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031682 name: G-protein gamma-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein gamma subunit." [GOC:mah] synonym: "G-gamma protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031683 name: G-protein beta/gamma-subunit complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0031684 name: obsolete heterotrimeric G-protein complex cycle namespace: biological_process def: "OBSOLETE. The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln] comment: The reason for obsoleting is that it is an arbitrary grouping term that groups the molecular functions required for the G-protein complex cycle, and this is not a bona fide biological process. is_obsolete: true [Term] id: GO:0031685 name: adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenosine receptor." [GOC:mah, GOC:nln] synonym: "adenosine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031686 name: A1 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A1 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A1 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031687 name: A2A adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2A adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2A adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031688 name: A2B adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2B adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2B adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031689 name: A3 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A3 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A3 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031690 name: adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenergic receptor." [GOC:mah, GOC:nln] synonym: "adrenergic receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031691 name: alpha-1A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031692 name: alpha-1B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031693 name: alpha-1D adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1D adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031694 name: alpha-2A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031695 name: alpha-2B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031696 name: alpha-2C adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2C adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031697 name: beta-1 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-1 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031698 name: beta-2 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-2 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031699 name: beta-3 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-3 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031700 name: adrenomedullin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenomedullin receptor." [GOC:mah, GOC:nln] synonym: "adrenomedullin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031701 name: angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an angiotensin receptor." [GOC:mah, GOC:nln] synonym: "angiotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031702 name: type 1 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT1 receptor binding" EXACT [] synonym: "type 1 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031703 name: type 2 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT2 receptor binding" EXACT [] synonym: "type 2 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031704 name: apelin receptor binding namespace: molecular_function alt_id: GO:0042569 def: "Interacting selectively and non-covalently with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] synonym: "apelin receptor ligand" NARROW [] synonym: "APJ receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031705 name: bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bombesin receptor." [GOC:mah, GOC:nln] synonym: "bombesin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031706 name: subtype 3 bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] synonym: "subtype 3 bombesin receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031707 name: endothelin A receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin A receptor." [GOC:mah, GOC:nln] synonym: "endothelin A receptor ligand" NARROW [] synonym: "endothelin-1 receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031708 name: endothelin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin B receptor." [GOC:mah, GOC:nln] synonym: "endothelin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031709 name: gastrin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "gastrin-releasing peptide receptor ligand" NARROW [] synonym: "GRP receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031710 name: neuromedin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin B receptor." [GOC:mah, GOC:nln] synonym: "neuromedin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031711 name: bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bradykinin receptor." [GOC:mah, GOC:nln] synonym: "bradykinin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031712 name: B1 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B1 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B1 bradykinin receptor ligand" NARROW [] is_a: GO:0031711 ! bradykinin receptor binding [Term] id: GO:0031713 name: B2 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B2 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B2 bradykinin receptor ligand" NARROW [] is_a: GO:0031711 ! bradykinin receptor binding [Term] id: GO:0031714 name: C5a anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031715 name: C5L2 anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding [Term] id: GO:0031716 name: calcitonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a calcitonin receptor." [GOC:mah, GOC:nln] synonym: "calcitonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031717 name: cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "cannabinoid receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031718 name: type 1 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 1 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031719 name: type 2 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 2 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031720 name: haptoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0031721 name: hemoglobin alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin alpha chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031722 name: hemoglobin beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin beta chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031723 name: CXCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR4 chemokine receptor ligand" NARROW [] synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031724 name: CXCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR5 chemokine receptor ligand" NARROW [] synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031725 name: CXCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "bonzo receptor binding" EXACT [] synonym: "CXCR6 chemokine receptor ligand" NARROW [] synonym: "STRL33 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031726 name: CCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR1 chemokine receptor ligand" NARROW [] synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031727 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031728 name: CCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR3 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR3 chemokine receptor ligand" NARROW [] synonym: "eosinophil eotaxin receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031729 name: CCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR4 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031730 name: CCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR5 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031731 name: CCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR6 chemokine receptor ligand" NARROW [] synonym: "LARC receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031732 name: CCR7 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR7 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR7 chemokine receptor ligand" NARROW [] synonym: "MIP-3 beta receptor binding" EXACT [] synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031733 name: CCR8 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR8 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR8 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031734 name: CCR9 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR9 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR9 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031735 name: CCR10 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR10 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR10 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031736 name: CCR11 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR11 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR11 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031737 name: CX3C chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CX3C chemokine receptor." [GOC:mah, GOC:nln] synonym: "CX3C chemokine receptor ligand" NARROW [] synonym: "fractalkine receptor binding" EXACT [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0031738 name: XCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a XCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "lymphotactin receptor binding" EXACT [] synonym: "XCR1 chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0031739 name: cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "cholecystokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031740 name: type A cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type A cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type A cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031741 name: type B gastrin/cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031745 name: cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031746 name: type 1 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031747 name: type 2 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031748 name: D1 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D1 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1 dopamine receptor ligand" NARROW [] synonym: "D1A dopamine receptor binding" EXACT [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031749 name: D2 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D2 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D2 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031750 name: D3 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D3 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D3 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031751 name: D4 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D4 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D4 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031752 name: D5 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1B dopamine receptor binding" EXACT [] synonym: "D5 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031753 name: endothelial differentiation G protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelial differentiation G protein-coupled receptor." [GOC:mah, GOC:nln] synonym: "endothelial differentiation G-protein coupled receptor binding" EXACT [] synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031754 name: Edg-1 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031755 name: Edg-2 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA1 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031756 name: Edg-3 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031757 name: Edg-4 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA2 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031758 name: Edg-5 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031759 name: Edg-6 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031760 name: Edg-7 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA3 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031761 name: fMet-Leu-Phe receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] synonym: "fMet-Leu-Phe receptor ligand" NARROW [] synonym: "N-formyl peptide receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031762 name: follicle-stimulating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln] synonym: "follicle stimulating hormone receptor binding" EXACT [] synonym: "follicle stimulating hormone receptor ligand" NARROW [] synonym: "FSH receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031763 name: galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a galanin receptor." [GOC:mah, GOC:nln] synonym: "galanin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031764 name: type 1 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 1 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031765 name: type 2 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 2 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031766 name: type 3 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 3 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031767 name: gastric inhibitory polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031768 name: ghrelin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ghrelin receptor." [GOC:mah, GOC:nln] synonym: "ghrelin receptor ligand" NARROW [] synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031769 name: glucagon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glucagon receptor." [GOC:mah, GOC:nln] synonym: "glucagon receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031770 name: growth hormone-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031771 name: type 1 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 1 hypocretin receptor ligand" NARROW [] synonym: "type 1 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031772 name: type 2 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 2 hypocretin receptor ligand" NARROW [] synonym: "type 2 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031773 name: kisspeptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kisspeptin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled receptor 54 binding" EXACT [] synonym: "hOT7T175 receptor binding" EXACT [] synonym: "hypogonadotropin-1 receptor binding" EXACT [] synonym: "KiSS-1 receptor binding" EXACT [] synonym: "kisspeptin receptor ligand" NARROW [] synonym: "metastin receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031774 name: leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a leukotriene receptor." [GOC:mah, GOC:nln] synonym: "leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031775 name: lutropin-choriogonadotropic hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031776 name: melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031777 name: type 1 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031778 name: type 2 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031779 name: melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanocortin receptor." [GOC:mah, GOC:nln] synonym: "melanocortin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031780 name: corticotropin hormone receptor binding namespace: molecular_function alt_id: GO:0071856 def: "Interacting selectively and non-covalently with a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] synonym: "ACTH receptor binding" EXACT [] synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph] synonym: "corticotropin receptor binding" EXACT [GOC:bf] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031781 name: type 3 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 3 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031782 name: type 4 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 4 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031783 name: type 5 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 5 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031784 name: melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melatonin receptor." [GOC:mah, GOC:nln] synonym: "melatonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031785 name: type 1A melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1A melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1A melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031786 name: type 1B melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1B melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031787 name: H9 melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H9 melatonin receptor." [GOC:mah, GOC:nln] synonym: "H9 melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031788 name: motilin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a motilin receptor." [GOC:mah, GOC:nln] synonym: "motilin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031789 name: G protein-coupled acetylcholine receptor binding namespace: molecular_function alt_id: GO:0031790 alt_id: GO:0031791 alt_id: GO:0031792 alt_id: GO:0031793 alt_id: GO:0031794 def: "Interacting selectively and non-covalently with a G protein-coupled acetylcholine receptor." [GOC:bf, GOC:mah, GOC:nln] synonym: "G-protein coupled acetylcholine receptor binding" EXACT [] synonym: "M1 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M2 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M3 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M4 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M5 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "muscarinic acetylcholine receptor binding" EXACT [GOC:bf] synonym: "muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031795 name: G protein-coupled GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) GABA receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled GABA receptor binding" EXACT [] synonym: "GABAB receptor binding" EXACT [] synonym: "metabotropic GABA receptor binding" EXACT [GOC:bf] synonym: "metabotropic GABA receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0050811 ! GABA receptor binding [Term] id: GO:0031796 name: type 1 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! G protein-coupled GABA receptor binding [Term] id: GO:0031797 name: type 2 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! G protein-coupled GABA receptor binding [Term] id: GO:0031798 name: type 1 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031799 name: type 2 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031800 name: type 3 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031801 name: type 4 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031802 name: type 5 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031803 name: type 6 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031804 name: type 7 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031805 name: type 8 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031806 name: G protein-coupled histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) histamine receptor." [GOC:mah, GOC:nln, PMID:12679144] synonym: "G-protein coupled histamine receptor binding" EXACT [] synonym: "metabotropic histamine receptor binding" EXACT [GOC:bf] synonym: "metabotropic histamine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031807 name: H1 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H1 histamine receptor." [GOC:mah, GOC:nln] synonym: "H1 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031808 name: H2 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H2 histamine receptor." [GOC:mah, GOC:nln] synonym: "H2 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031809 name: H3 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H3 histamine receptor." [GOC:mah, GOC:nln] synonym: "H3 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031810 name: H4 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H4 histamine receptor." [GOC:mah, GOC:nln] synonym: "H4 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031811 name: G protein-coupled nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) nucleotide receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled nucleotide receptor binding" EXACT [] synonym: "metabotropic nucleotide receptor binding" EXACT [GOC:bf] synonym: "metabotropic nucleotide receptor ligand" NARROW [] synonym: "P2Y receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031812 name: P2Y1 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y1 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031813 name: P2Y2 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y2 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031814 name: P2Y4 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y4 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031815 name: P2Y5 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y5 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031816 name: P2Y6 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y6 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031817 name: P2Y8 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y8 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031818 name: P2Y9 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y9 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031819 name: P2Y10 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y10 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031820 name: P2Y11 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y11 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031821 name: G protein-coupled serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic serotonin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled serotonin receptor binding" EXACT [] synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] synonym: "metabotropic serotonin receptor binding" EXACT [GOC:bf] synonym: "metabotropic serotonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031822 name: type 1B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] synonym: "type 1B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031823 name: type 1D serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1D serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] synonym: "type 1D serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031824 name: type 1E serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1E serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] synonym: "type 1E serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031825 name: type 1F serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1F serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] synonym: "type 1F serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031826 name: type 2A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] synonym: "type 2A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031827 name: type 2B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] synonym: "type 2B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031828 name: type 2C serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2C serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] synonym: "type 2C serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031829 name: type 4 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] synonym: "type 4 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031830 name: type 5A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] synonym: "type 5A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031831 name: type 5B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] synonym: "type 5B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031832 name: type 6 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] synonym: "type 6 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031833 name: type 7 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] synonym: "type 7 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031834 name: neurokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurokinin receptor." [GOC:mah, GOC:nln] synonym: "neurokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031835 name: substance P receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance P receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-1 receptor binding" EXACT [] synonym: "substance P receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031836 name: neuromedin K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-B receptor binding" EXACT [] synonym: "neuromedin K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031837 name: substance K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-A receptor binding" EXACT [] synonym: "substance K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031838 name: haptoglobin-hemoglobin complex namespace: cellular_component def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0031839 name: type 1 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031840 name: type 2 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031841 name: neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "neuropeptide Y receptor ligand" NARROW [] synonym: "NPY receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031842 name: type 1 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031843 name: type 2 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031844 name: type 4 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "pancreatic polypeptide receptor binding" EXACT [] synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031845 name: type 5 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031846 name: neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotensin receptor." [GOC:mah, GOC:nln] synonym: "neurotensin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031847 name: type 1 neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neurotensin receptor." [GOC:mah, GOC:nln] synonym: "type 1 neurotensin receptor ligand" NARROW [] is_a: GO:0031846 ! neurotensin receptor binding [Term] id: GO:0031848 name: protection from non-homologous end joining at telomere namespace: biological_process def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah] synonym: "protection from NHEJ-mediated telomere fusion" EXACT [] is_a: GO:0043247 ! telomere maintenance in response to DNA damage relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031849 name: olfactory receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an olfactory receptor." [GOC:mah, GOC:nln] synonym: "olfactory receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031850 name: delta-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a delta-type opioid receptor." [GOC:mah, GOC:nln] synonym: "delta-type opioid receptor ligand" NARROW [] synonym: "enkephalin receptor binding" RELATED [GOC:sl] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031851 name: kappa-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kappa-type opioid receptor." [GOC:mah, GOC:nln] synonym: "dynorphin receptor binding" RELATED [] synonym: "kappa-type opioid receptor ligand" NARROW [GOC:sl] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031852 name: mu-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mu-type opioid receptor." [GOC:mah, GOC:nln, GOC:sl] synonym: "morphine receptor binding" RELATED [GOC:sl] synonym: "mu-type opioid receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031853 name: nociceptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nociceptin receptor." [GOC:mah, GOC:nln] synonym: "nociceptin receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031854 name: orexigenic neuropeptide QRFP receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031855 name: oxytocin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an oxytocin receptor." [GOC:mah, GOC:nln] synonym: "oxytocin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031856 name: parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "parathyroid hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031857 name: type 1 parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] is_a: GO:0031856 ! parathyroid hormone receptor binding [Term] id: GO:0031858 name: pituitary adenylate cyclase-activating polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln] synonym: "PACAP receptor binding" EXACT [] synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031859 name: platelet activating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a platelet activating factor receptor." [GOC:mah, GOC:nln] synonym: "platelet activating factor receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031860 name: telomeric 3' overhang formation namespace: biological_process def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw] synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031861 name: prolactin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "prolactin-releasing peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031862 name: prostanoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostanoid receptor." [GOC:mah, GOC:nln] synonym: "prostanoid receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031863 name: prostaglandin D2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin D2 receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin D2 receptor ligand" NARROW [] synonym: "prostanoid DP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031864 name: EP1 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP1 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031865 name: EP2 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP2 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031866 name: EP3 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP3 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031867 name: EP4 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP4 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031868 name: prostaglandin F2-alpha receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] synonym: "prostanoid FP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031869 name: prostacyclin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostacyclin receptor." [GOC:mah, GOC:nln] synonym: "prostacyclin receptor ligand" NARROW [] synonym: "prostanoid IP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031870 name: thromboxane A2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a thromboxane A2 receptor." [GOC:mah, GOC:nln] synonym: "prostanoid TP receptor binding" EXACT [] synonym: "thromboxane A2 receptor ligand" NARROW [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031871 name: proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "proteinase activated receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031872 name: type 1 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "thrombin receptor binding" EXACT [] synonym: "type 1 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031873 name: type 2 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 2 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031874 name: type 3 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 3 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031875 name: type 4 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 4 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031876 name: secretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a secretin receptor." [GOC:mah, GOC:nln] synonym: "secretin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031877 name: somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a somatostatin receptor." [GOC:mah, GOC:nln] synonym: "somatostatin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031878 name: type 1 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 1 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031879 name: type 2 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 2 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031880 name: type 3 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 3 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031881 name: type 4 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 4 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031882 name: type 5 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 5 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031883 name: taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a taste receptor." [GOC:mah, GOC:nln] synonym: "taste receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031884 name: type 1 member 1 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 1 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031885 name: type 1 member 2 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 2 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031886 name: type 1 member 3 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] synonym: "sweet taste receptor binding" EXACT [] synonym: "type 1 member 3 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031887 name: lipid droplet transport along microtubule namespace: biological_process def: "The directed movement of a lipid droplet along a microtubule, mediated by motor proteins." [PMID:9491895] synonym: "adiposome transport along microtubule" EXACT [] synonym: "lipid body transport along microtubule" EXACT [] synonym: "lipid particle transport along microtubule" EXACT [] is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0031889 name: urotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a urotensin receptor." [GOC:mah, GOC:nln] synonym: "urotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031890 name: vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "VIP receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031891 name: type 1 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 2 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031892 name: type 2 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 3 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031893 name: vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasopressin receptor." [GOC:mah, GOC:nln] synonym: "vasopressin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031894 name: V1A vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1A vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1A vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031895 name: V1B vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1B vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1B vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031896 name: V2 vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V2 vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V2 vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031897 name: Tic complex namespace: cellular_component def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] synonym: "chloroplast inner membrane translocase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031898 name: chromoplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0031899 name: chromoplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031900 name: chromoplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031901 name: early endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an early endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031902 name: late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a late endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031903 name: microbody membrane namespace: cellular_component def: "The lipid bilayer surrounding a microbody." [GOC:mah] is_a: GO:0042579 ! microbody is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane [Term] id: GO:0031904 name: endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endosome." [GOC:mah] xref: NIF_Subcellular:sao1547508851 is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005768 ! endosome [Term] id: GO:0031905 name: early endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an early endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031906 name: late endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a late endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031907 name: microbody lumen namespace: cellular_component def: "The volume enclosed by the membranes of a microbody." [GOC:mah] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0042579 ! microbody [Term] id: GO:0031908 name: glyoxysomal lumen namespace: cellular_component def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] is_a: GO:0005782 ! peroxisomal matrix [Term] id: GO:0031910 name: cytostome namespace: cellular_component def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] xref: Wikipedia:Cytostome is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0031911 name: cytoproct namespace: cellular_component def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0031912 name: oral apparatus namespace: cellular_component def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031913 name: contractile vacuole pore namespace: cellular_component def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031914 name: negative regulation of synaptic plasticity namespace: biological_process def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "down regulation of synaptic plasticity" EXACT [] synonym: "down-regulation of synaptic plasticity" EXACT [] synonym: "downregulation of synaptic plasticity" EXACT [] synonym: "inhibition of synaptic plasticity" NARROW [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031915 name: positive regulation of synaptic plasticity namespace: biological_process def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "activation of synaptic plasticity" NARROW [] synonym: "stimulation of synaptic plasticity" NARROW [] synonym: "up regulation of synaptic plasticity" EXACT [] synonym: "up-regulation of synaptic plasticity" EXACT [] synonym: "upregulation of synaptic plasticity" EXACT [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031916 name: regulation of synaptic metaplasticity namespace: biological_process def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031917 name: negative regulation of synaptic metaplasticity namespace: biological_process def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "down regulation of synaptic metaplasticity" EXACT [] synonym: "down-regulation of synaptic metaplasticity" EXACT [] synonym: "downregulation of synaptic metaplasticity" EXACT [] synonym: "inhibition of synaptic metaplasticity" NARROW [] is_a: GO:0031914 ! negative regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031918 name: positive regulation of synaptic metaplasticity namespace: biological_process def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "activation of synaptic metaplasticity" NARROW [] synonym: "stimulation of synaptic metaplasticity" NARROW [] synonym: "up regulation of synaptic metaplasticity" EXACT [] synonym: "up-regulation of synaptic metaplasticity" EXACT [] synonym: "upregulation of synaptic metaplasticity" EXACT [] is_a: GO:0031915 ! positive regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031919 name: vitamin B6 transport namespace: biological_process def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0031920 name: pyridoxal transport namespace: biological_process def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015695 ! organic cation transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031921 name: pyridoxal phosphate transport namespace: biological_process def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0031922 name: pyridoxamine transport namespace: biological_process def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031923 name: pyridoxine transport namespace: biological_process def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031924 name: vitamin B6 transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other." [GOC:mah] synonym: "vitamin B6 transporter activity" RELATED [] is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0031919 ! vitamin B6 transport [Term] id: GO:0031925 name: pyridoxal transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxal transporter activity" BROAD [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903090 ! pyridoxal transmembrane transport [Term] id: GO:0031926 name: pyridoxal phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0031927 name: pyridoxamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903091 ! pyridoxamine transmembrane transport [Term] id: GO:0031928 name: pyridoxine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxine transporter activity" BROAD [] is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903092 ! pyridoxine transmembrane transport [Term] id: GO:0031929 name: TOR signaling namespace: biological_process def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. synonym: "target of rapamycin signaling pathway" EXACT [] synonym: "target of rapamycin signalling pathway" EXACT [] synonym: "TOR signal transduction" EXACT [GOC:signaling] synonym: "TOR signaling cascade" RELATED [GOC:signaling] synonym: "TOR signaling pathway" EXACT [] synonym: "TOR signalling pathway" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031930 name: mitochondria-nucleus signaling pathway namespace: biological_process def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799] synonym: "mitochondria-nucleus signal transduction" EXACT [GOC:signaling] synonym: "mitochondrial signaling pathway" EXACT [] synonym: "mitochondrial signalling pathway" EXACT [] synonym: "retrograde response" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0031931 name: TORC1 complex namespace: cellular_component def: "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787] synonym: "dTOR/dRaptor complex" NARROW [PMID:17183368] synonym: "dTORC1" NARROW [PMID:17183368] synonym: "mTORC1" NARROW [PMID:18765678, PMID:21548787] synonym: "nutrient sensitive complex" EXACT [] synonym: "rapamycin and nutrient-sensitive TOR complex" EXACT [PMID:21548787] synonym: "TOR complex 1" EXACT [] synonym: "TORC 1 complex" EXACT [] synonym: "TORC1" EXACT [PMID:21548787] xref: Wikipedia:MTORC1 is_a: GO:0038201 ! TOR complex [Term] id: GO:0031932 name: TORC2 complex namespace: cellular_component def: "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787] synonym: "mTORC2" NARROW [PMID:20496258, PMID:21548787] synonym: "rapamycin and nutrient-insensitive TOR complex" EXACT [PMID:21548787] synonym: "TOR complex 2" EXACT [] synonym: "TORC 2 complex" EXACT [] synonym: "TORC2" EXACT [PMID:21548787] xref: Wikipedia:MTORC1 is_a: GO:0038201 ! TOR complex [Term] id: GO:0031933 name: telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] synonym: "telomeric chromatin" BROAD [GOC:pr] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000781 ! chromosome, telomeric region relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0031934 name: mating-type region heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] is_a: GO:0000792 ! heterochromatin [Term] id: GO:0031935 name: regulation of chromatin silencing namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] synonym: "regulation of heterochromatic silencing" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0060968 ! regulation of gene silencing is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006342 ! chromatin silencing relationship: regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031936 name: negative regulation of chromatin silencing namespace: biological_process alt_id: GO:0006345 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "down regulation of chromatin silencing" EXACT [] synonym: "down-regulation of chromatin silencing" EXACT [] synonym: "downregulation of chromatin silencing" EXACT [] synonym: "inhibition of chromatin silencing" NARROW [] synonym: "loss of chromatin silencing" EXACT [] synonym: "negative regulation of heterochromatic silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0045815 ! positive regulation of gene expression, epigenetic is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0060969 ! negative regulation of gene silencing is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006342 ! chromatin silencing relationship: negatively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031937 name: positive regulation of chromatin silencing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "activation of chromatin silencing" NARROW [] synonym: "positive regulation of heterochromatic silencing" EXACT [] synonym: "stimulation of chromatin silencing" NARROW [] synonym: "up regulation of chromatin silencing" EXACT [] synonym: "up-regulation of chromatin silencing" EXACT [] synonym: "upregulation of chromatin silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006342 ! chromatin silencing relationship: positively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031938 name: regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah] synonym: "regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006348 ! chromatin silencing at telomere relationship: regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031939 name: negative regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "down regulation of chromatin silencing at telomere" EXACT [] synonym: "down-regulation of chromatin silencing at telomere" EXACT [] synonym: "downregulation of chromatin silencing at telomere" EXACT [] synonym: "inhibition of chromatin silencing at telomere" NARROW [] synonym: "negative regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006348 ! chromatin silencing at telomere relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031940 name: positive regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "activation of chromatin silencing at telomere" NARROW [] synonym: "positive regulation of heterochromatic silencing at telomere" EXACT [] synonym: "stimulation of chromatin silencing at telomere" NARROW [] synonym: "up regulation of chromatin silencing at telomere" EXACT [] synonym: "up-regulation of chromatin silencing at telomere" EXACT [] synonym: "upregulation of chromatin silencing at telomere" EXACT [] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006348 ! chromatin silencing at telomere relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031941 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: Wikipedia:Actin is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005884 ! actin filament [Term] id: GO:0031942 name: i-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0031943 name: regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008211 ! glucocorticoid metabolic process relationship: regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031944 name: negative regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid metabolic process" EXACT [] synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] synonym: "downregulation of glucocorticoid metabolic process" EXACT [] synonym: "inhibition of glucocorticoid metabolic process" NARROW [] synonym: "negative regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008211 ! glucocorticoid metabolic process relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031945 name: positive regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid metabolic process" NARROW [] synonym: "positive regulation of glucocorticoid metabolism" EXACT [] synonym: "stimulation of glucocorticoid metabolic process" NARROW [] synonym: "up regulation of glucocorticoid metabolic process" EXACT [] synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] synonym: "upregulation of glucocorticoid metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008211 ! glucocorticoid metabolic process relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031946 name: regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006704 ! glucocorticoid biosynthetic process relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031947 name: negative regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031948 name: positive regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid biosynthetic process" NARROW [] synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031949 name: regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006713 ! glucocorticoid catabolic process relationship: regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031950 name: negative regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid catabolic process" EXACT [] synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] synonym: "downregulation of glucocorticoid catabolic process" EXACT [] synonym: "inhibition of glucocorticoid catabolic process" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006713 ! glucocorticoid catabolic process relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031951 name: positive regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid catabolic process" NARROW [] synonym: "stimulation of glucocorticoid catabolic process" NARROW [] synonym: "up regulation of glucocorticoid catabolic process" EXACT [] synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] synonym: "upregulation of glucocorticoid catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006713 ! glucocorticoid catabolic process relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031952 name: regulation of protein autophosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046777 ! protein autophosphorylation relationship: has_part GO:0045859 ! regulation of protein kinase activity relationship: regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031953 name: negative regulation of protein autophosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "down regulation of protein amino acid autophosphorylation" EXACT [] synonym: "down-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "downregulation of protein amino acid autophosphorylation" EXACT [] synonym: "inhibition of protein amino acid autophosphorylation" NARROW [] synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046777 ! protein autophosphorylation relationship: has_part GO:0006469 ! negative regulation of protein kinase activity relationship: negatively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031954 name: positive regulation of protein autophosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "activation of protein amino acid autophosphorylation" NARROW [] synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid autophosphorylation" NARROW [] synonym: "up regulation of protein amino acid autophosphorylation" EXACT [] synonym: "up-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "upregulation of protein amino acid autophosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046777 ! protein autophosphorylation relationship: has_part GO:0045860 ! positive regulation of protein kinase activity relationship: positively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031955 name: short-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6." [EC:6.2.1.3, GOC:mah] synonym: "short-chain fatty acid activation" RELATED [] synonym: "short-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031956 name: medium-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12." [EC:6.2.1.3, GOC:mah] synonym: "medium-chain fatty acid activation" RELATED [] synonym: "medium-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031957 name: very long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [EC:6.2.1.3, GOC:mah] synonym: "very-long-chain fatty acid activation" RELATED [] synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT [] xref: Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA" xref: Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA" xref: Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA" is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031958 name: corticosteroid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "corticosteroid receptor signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0031959 name: mineralocorticoid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "mineralocorticoid receptor signalling pathway" EXACT [] is_a: GO:0031958 ! corticosteroid receptor signaling pathway [Term] id: GO:0031960 name: response to corticosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] synonym: "response to corticosteroid stimulus" EXACT [GOC:dos] is_a: GO:0048545 ! response to steroid hormone [Term] id: GO:0031961 name: cortisol receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cortisol receptor." [GOC:mah, PMID:12511169] is_a: GO:0035259 ! glucocorticoid receptor binding [Term] id: GO:0031962 name: mineralocorticoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mineralocorticoid receptor." [GOC:mah, PMID:12511169] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0031963 name: cortisol receptor activity namespace: molecular_function def: "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:mah, PMID:12511169] comment: For cortisol receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. is_a: GO:0004883 ! glucocorticoid receptor activity [Term] id: GO:0031964 name: beta-alanyl-histamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine." [GOC:rc, PMID:16299587] synonym: "carcinine hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] xref: NIF_Subcellular:sao1045389829 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0031975 ! envelope relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031970 name: organelle envelope lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] synonym: "organelle intermembrane space" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031972 name: chloroplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] synonym: "chloroplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031973 name: chromoplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] synonym: "chromoplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space relationship: part_of GO:0031898 ! chromoplast envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0031976 name: plastid thylakoid namespace: cellular_component def: "Any thylakoid within a plastid." [GOC:pz] is_a: GO:0009579 ! thylakoid is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009536 ! plastid [Term] id: GO:0031977 name: thylakoid lumen namespace: cellular_component def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009579 ! thylakoid [Term] id: GO:0031978 name: plastid thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] is_a: GO:0031977 ! thylakoid lumen relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0031979 name: plasma membrane-derived thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid lumen" EXACT [] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031983 name: vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] xref: NIF_Subcellular:sao797538226 is_a: GO:0043233 ! organelle lumen relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0031984 name: organelle subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. synonym: "suborganelle compartment" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0031985 name: Golgi cisterna namespace: cellular_component def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532] xref: NIF_Subcellular:sao561419532 is_a: GO:0098791 ! Golgi subcompartment relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0031986 name: proteinoplast namespace: cellular_component def: "A leucoplast in which protein is stored." [GOC:pz] xref: Wikipedia:Proteinoplast is_a: GO:0009516 ! leucoplast [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion intersection_of: GO:0040011 ! locomotion intersection_of: part_of GO:0007626 ! locomotory behavior relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0031989 name: bombesin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "bombesin receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0031990 name: mRNA export from nucleus in response to heat stress namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw] synonym: "mRNA export from cell nucleus during heat stress" EXACT [] synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb] is_a: GO:0006406 ! mRNA export from nucleus is_a: GO:0034605 ! cellular response to heat [Term] id: GO:0031991 name: regulation of actomyosin contractile ring contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0110020 ! regulation of actomyosin structure organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000916 ! actomyosin contractile ring contraction relationship: regulates GO:0000916 ! actomyosin contractile ring contraction [Term] id: GO:0031992 name: energy transducer activity namespace: molecular_function def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] subset: goslim_pir synonym: "light harvesting activity" RELATED [] synonym: "photon capture" RELATED [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0031993 name: light transducer activity namespace: molecular_function def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] is_a: GO:0031992 ! energy transducer activity relationship: part_of GO:0009583 ! detection of light stimulus [Term] id: GO:0031994 name: insulin-like growth factor I binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah] subset: goslim_chembl synonym: "IGF-I binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031995 name: insulin-like growth factor II binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah] subset: goslim_chembl synonym: "IGF-II binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031996 name: thioesterase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any thioesterase enzyme." [GOC:dl] synonym: "thiolesterase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0031997 name: N-terminal myristoylation domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] is_a: GO:0047485 ! protein N-terminus binding [Term] id: GO:0031998 name: regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006635 ! fatty acid beta-oxidation relationship: regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0031999 name: negative regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "down regulation of fatty acid beta-oxidation" EXACT [] synonym: "down-regulation of fatty acid beta-oxidation" EXACT [] synonym: "downregulation of fatty acid beta-oxidation" EXACT [] synonym: "inhibition of fatty acid beta-oxidation" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046322 ! negative regulation of fatty acid oxidation is_a: GO:0050995 ! negative regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006635 ! fatty acid beta-oxidation relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032000 name: positive regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "activation of fatty acid beta-oxidation" NARROW [] synonym: "stimulation of fatty acid beta-oxidation" NARROW [] synonym: "up regulation of fatty acid beta-oxidation" EXACT [] synonym: "up-regulation of fatty acid beta-oxidation" EXACT [] synonym: "upregulation of fatty acid beta-oxidation" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046321 ! positive regulation of fatty acid oxidation is_a: GO:0050996 ! positive regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032001 name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." [EC:2.4.1.24] synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "D-glucosyltransferase" BROAD [] synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] synonym: "T-enzyme" NARROW [] xref: EC:2.4.1.24 xref: MetaCyc:2.4.1.24-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0032002 name: interleukin-28 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1)." [GOC:rph] synonym: "IL-28 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0032003 name: interleukin-28 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-28 receptor." [GOC:rph] synonym: "IL-28" NARROW [] synonym: "interleukin-28 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032005 name: signal transduction involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion intersection_of: GO:0007165 ! signal transduction intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0032006 name: regulation of TOR signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "regulation of target of rapamycin signaling pathway" EXACT [] synonym: "regulation of target of rapamycin signalling pathway" EXACT [] synonym: "regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "regulation of TOR signaling pathway" EXACT [] synonym: "regulation of TOR signalling pathway" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031929 ! TOR signaling relationship: regulates GO:0031929 ! TOR signaling [Term] id: GO:0032007 name: negative regulation of TOR signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "down regulation of TOR signaling pathway" EXACT [] synonym: "down-regulation of TOR signaling pathway" EXACT [] synonym: "downregulation of TOR signaling pathway" EXACT [] synonym: "inhibition of TOR signaling pathway" NARROW [] synonym: "negative regulation of target of rapamycin signaling pathway" EXACT [] synonym: "negative regulation of target of rapamycin signalling pathway" EXACT [] synonym: "negative regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of TOR signaling pathway" EXACT [] synonym: "negative regulation of TOR signalling pathway" EXACT [] is_a: GO:0032006 ! regulation of TOR signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031929 ! TOR signaling relationship: negatively_regulates GO:0031929 ! TOR signaling [Term] id: GO:0032008 name: positive regulation of TOR signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "activation of TOR signaling pathway" NARROW [] synonym: "positive regulation of target of rapamycin signaling pathway" EXACT [] synonym: "positive regulation of target of rapamycin signalling pathway" EXACT [] synonym: "positive regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of TOR signaling pathway" EXACT [] synonym: "positive regulation of TOR signalling pathway" EXACT [] synonym: "stimulation of TOR signaling pathway" NARROW [] synonym: "up regulation of TOR signaling pathway" EXACT [] synonym: "up-regulation of TOR signaling pathway" EXACT [] synonym: "upregulation of TOR signaling pathway" EXACT [] is_a: GO:0032006 ! regulation of TOR signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031929 ! TOR signaling relationship: positively_regulates GO:0031929 ! TOR signaling [Term] id: GO:0032009 name: early phagosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] synonym: "early phagocytic vesicle" EXACT [] is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032010 name: phagolysosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753] synonym: "late phagocytic vesicle" RELATED [] synonym: "late phagosome" RELATED [] xref: Wikipedia:Phagolysosome is_a: GO:0005767 ! secondary lysosome is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032011 name: ARF protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032012 name: regulation of ARF protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032011 ! ARF protein signal transduction relationship: regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032013 name: negative regulation of ARF protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "down regulation of ARF protein signal transduction" EXACT [] synonym: "down-regulation of ARF protein signal transduction" EXACT [] synonym: "downregulation of ARF protein signal transduction" EXACT [] synonym: "inhibition of ARF protein signal transduction" NARROW [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032011 ! ARF protein signal transduction relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032014 name: positive regulation of ARF protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "activation of ARF protein signal transduction" NARROW [] synonym: "stimulation of ARF protein signal transduction" NARROW [] synonym: "up regulation of ARF protein signal transduction" EXACT [] synonym: "up-regulation of ARF protein signal transduction" EXACT [] synonym: "upregulation of ARF protein signal transduction" EXACT [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032011 ! ARF protein signal transduction relationship: positively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032015 name: regulation of Ran protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031291 ! Ran protein signal transduction relationship: regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032016 name: negative regulation of Ran protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "down regulation of Ran protein signal transduction" EXACT [] synonym: "down-regulation of Ran protein signal transduction" EXACT [] synonym: "downregulation of Ran protein signal transduction" EXACT [] synonym: "inhibition of Ran protein signal transduction" NARROW [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031291 ! Ran protein signal transduction relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032017 name: positive regulation of Ran protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "activation of Ran protein signal transduction" NARROW [] synonym: "stimulation of Ran protein signal transduction" NARROW [] synonym: "up regulation of Ran protein signal transduction" EXACT [] synonym: "up-regulation of Ran protein signal transduction" EXACT [] synonym: "upregulation of Ran protein signal transduction" EXACT [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031291 ! Ran protein signal transduction relationship: positively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032018 name: 2-methylbutanol:NADP oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] synonym: "2-methylbutanal reductase (NADP) activity" EXACT [] synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT [] is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0032019 name: mitochondrial cloud namespace: cellular_component def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] synonym: "Balbiani body" EXACT [] synonym: "mitochondrial aggregate" RELATED [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032020 name: ISG15-protein conjugation namespace: biological_process def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0032021 name: NELF complex namespace: cellular_component def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] synonym: "negative elongation factor complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032023 name: trypsinogen activation namespace: biological_process def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah] synonym: "cleavage of trypsinogen to trypsin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0032024 name: positive regulation of insulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] synonym: "activation of insulin secretion" NARROW [] synonym: "stimulation of insulin secretion" NARROW [] synonym: "up regulation of insulin secretion" EXACT [] synonym: "up-regulation of insulin secretion" EXACT [] synonym: "upregulation of insulin secretion" EXACT [] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030073 ! insulin secretion relationship: positively_regulates GO:0030073 ! insulin secretion [Term] id: GO:0032025 name: response to cobalt ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032026 name: response to magnesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032027 name: myosin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032028 name: myosin head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032029 name: myosin tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032030 name: myosin I light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032027 ! myosin light chain binding [Term] id: GO:0032031 name: myosin I head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032032 name: myosin I tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032033 name: myosin II light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah] is_a: GO:0032027 ! myosin light chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032034 name: myosin II head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032035 name: myosin II tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032036 name: myosin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032037 name: myosin I heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032038 name: myosin II heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032039 name: integrator complex namespace: cellular_component def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] comment: Changed parents, see https://github.com/geneontology/go-ontology/issues/15979 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032040 name: small-subunit processome namespace: cellular_component def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] synonym: "small subunit processome" EXACT [] synonym: "SSU processome" EXACT [] is_a: GO:0030684 ! preribosome relationship: has_part GO:0034455 ! t-UTP complex [Term] id: GO:0032041 name: NAD-dependent histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] xref: EC:3.5.1.98 is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific) [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process intersection_of: GO:0006259 ! DNA metabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0000002 ! mitochondrial genome maintenance [Term] id: GO:0032043 name: mitochondrial DNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA breakdown" EXACT [] synonym: "mitochondrial DNA catabolism" EXACT [] synonym: "mitochondrial DNA degradation" EXACT [] synonym: "mtDNA breakdown" EXACT [] synonym: "mtDNA catabolic process" EXACT [] synonym: "mtDNA catabolism" EXACT [] synonym: "mtDNA degradation" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006308 ! DNA catabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0032044 name: DSIF complex namespace: cellular_component def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865] synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] synonym: "DRB sensitivity inducing factor complex" EXACT [] synonym: "Spt4-Spt5 complex" EXACT [] synonym: "Spt5-Spt4 complex" EXACT [GOC:vw] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032045 name: guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032046 name: micropexophagy-specific membrane apparatus namespace: cellular_component def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] synonym: "micropexophagic apparatus" EXACT [] synonym: "MIPA" EXACT [] is_a: GO:0031984 ! organelle subcompartment relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0032047 name: mitosome namespace: cellular_component def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria." [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280] comment: In Giardia species, mitosomes are sometimes present between the two nuclei. synonym: "crypton" EXACT [] xref: Wikipedia:Mitosome is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032048 name: cardiolipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah] synonym: "cardiolipin metabolism" EXACT [] synonym: "diphosphatidylglycerol metabolic process" RELATED [] synonym: "diphosphatidylglycerol metabolism" RELATED [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process [Term] id: GO:0032049 name: cardiolipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah] synonym: "diphosphatidylglycerol biosynthesis" RELATED [] synonym: "diphosphatidylglycerol biosynthetic process" RELATED [] xref: MetaCyc:PWY-5269 is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process is_a: GO:0032048 ! cardiolipin metabolic process [Term] id: GO:0032050 name: clathrin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032051 name: clathrin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin light chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032052 name: bile acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0032053 name: ciliary basal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124] synonym: "microtubule basal body organisation" BROAD [GOC:mah] synonym: "microtubule basal body organization" BROAD [] synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0044782 ! cilium organization [Term] id: GO:0032055 name: negative regulation of translation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation in response to stress" EXACT [] synonym: "down-regulation of translation in response to stress" EXACT [] synonym: "downregulation of translation in response to stress" EXACT [] synonym: "inhibition of translation in response to stress" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0032056 name: positive regulation of translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation in response to stress" NARROW [] synonym: "stimulation of translation in response to stress" NARROW [] synonym: "up regulation of translation in response to stress" EXACT [] synonym: "up-regulation of translation in response to stress" EXACT [] synonym: "upregulation of translation in response to stress" EXACT [] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:0045727 ! positive regulation of translation [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045947 ! negative regulation of translational initiation [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291] subset: goslim_pir synonym: "plasma membrane bleb" EXACT [GOC:pr] xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0032061 name: negative regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation in response to osmotic stress" EXACT [] synonym: "downregulation of translation in response to osmotic stress" EXACT [] synonym: "inhibition of translation in response to osmotic stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032062 name: positive regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation in response to osmotic stress" NARROW [] synonym: "stimulation of translation in response to osmotic stress" NARROW [] synonym: "up regulation of translation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation in response to osmotic stress" EXACT [] synonym: "upregulation of translation in response to osmotic stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032063 name: negative regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "downregulation of translation initiation in response to osmotic stress" EXACT [] synonym: "inhibition of translation initiation in response to osmotic stress" NARROW [] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032064 name: positive regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation initiation in response to osmotic stress" NARROW [] synonym: "stimulation of translation initiation in response to osmotic stress" NARROW [] synonym: "up regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "upregulation of translation initiation in response to osmotic stress" EXACT [] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032065 name: maintenance of protein location in cell cortex namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] synonym: "cortical protein anchoring" RELATED [] synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005938 ! cell cortex relationship: occurs_in GO:0005938 ! cell cortex [Term] id: GO:0032067 name: type IV site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] synonym: "type IV restriction enzyme activity" EXACT [] is_a: GO:0015666 ! restriction endodeoxyribonuclease activity [Term] id: GO:0032068 name: type IV site-specific deoxyribonuclease complex namespace: cellular_component def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] synonym: "type IV restriction enzyme complex" EXACT [] is_a: GO:1905347 ! endodeoxyribonuclease complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032069 name: regulation of nuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "nuclease regulator activity" RELATED [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0051336 ! regulation of hydrolase activity is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004518 ! nuclease activity relationship: regulates GO:0004518 ! nuclease activity [Term] id: GO:0032070 name: regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease regulator" RELATED [] synonym: "DNase regulator" RELATED [] is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004536 ! deoxyribonuclease activity relationship: regulates GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0032071 name: regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "endodeoxyribonuclease regulator" RELATED [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004520 ! endodeoxyribonuclease activity relationship: regulates GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0032072 name: regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015666 ! restriction endodeoxyribonuclease activity relationship: regulates GO:0015666 ! restriction endodeoxyribonuclease activity [Term] id: GO:0032073 name: negative regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW [] synonym: "restriction alleviation" NARROW [] synonym: "restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "restriction enzyme inhibitor" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015666 ! restriction endodeoxyribonuclease activity relationship: negatively_regulates GO:0015666 ! restriction endodeoxyribonuclease activity [Term] id: GO:0032074 name: negative regulation of nuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "down regulation of nuclease activity" EXACT [] synonym: "down-regulation of nuclease activity" EXACT [] synonym: "downregulation of nuclease activity" EXACT [] synonym: "inhibition of nuclease activity" NARROW [] synonym: "nuclease inhibitor" RELATED [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004518 ! nuclease activity relationship: negatively_regulates GO:0004518 ! nuclease activity [Term] id: GO:0032075 name: positive regulation of nuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "activation of nuclease activity" NARROW [] synonym: "nuclease activator" RELATED [] synonym: "stimulation of nuclease activity" NARROW [] synonym: "up regulation of nuclease activity" EXACT [] synonym: "up-regulation of nuclease activity" EXACT [] synonym: "upregulation of nuclease activity" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004518 ! nuclease activity relationship: positively_regulates GO:0004518 ! nuclease activity [Term] id: GO:0032076 name: negative regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease inhibitor" RELATED [] synonym: "DNase inhibitor" RELATED [] synonym: "down regulation of deoxyribonuclease activity" EXACT [] synonym: "down-regulation of deoxyribonuclease activity" EXACT [] synonym: "downregulation of deoxyribonuclease activity" EXACT [] synonym: "inhibition of deoxyribonuclease activity" NARROW [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004536 ! deoxyribonuclease activity relationship: negatively_regulates GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0032077 name: positive regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "activation of deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activator" RELATED [] synonym: "DNase activator" RELATED [] synonym: "stimulation of deoxyribonuclease activity" NARROW [] synonym: "up regulation of deoxyribonuclease activity" EXACT [] synonym: "up-regulation of deoxyribonuclease activity" EXACT [] synonym: "upregulation of deoxyribonuclease activity" EXACT [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004536 ! deoxyribonuclease activity relationship: positively_regulates GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0032078 name: negative regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "down regulation of endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of endodeoxyribonuclease activity" EXACT [] synonym: "endodeoxyribonuclease inhibitor" RELATED [] synonym: "inhibition of endodeoxyribonuclease activity" NARROW [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004520 ! endodeoxyribonuclease activity relationship: negatively_regulates GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0032079 name: positive regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "activation of endodeoxyribonuclease activity" NARROW [] synonym: "endodeoxyribonuclease activator" RELATED [] synonym: "stimulation of endodeoxyribonuclease activity" NARROW [] synonym: "up regulation of endodeoxyribonuclease activity" EXACT [] synonym: "up-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "upregulation of endodeoxyribonuclease activity" EXACT [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004520 ! endodeoxyribonuclease activity relationship: positively_regulates GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0032080 name: negative regulation of type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type I restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type I restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type I restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032084 ! regulation of type I site-specific deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009035 ! type I site-specific deoxyribonuclease activity relationship: negatively_regulates GO:0009035 ! type I site-specific deoxyribonuclease activity [Term] id: GO:0032081 name: negative regulation of type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type II restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type II restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type II restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032085 ! regulation of type II site-specific deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009036 ! type II site-specific deoxyribonuclease activity relationship: negatively_regulates GO:0009036 ! type II site-specific deoxyribonuclease activity [Term] id: GO:0032082 name: negative regulation of type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type III restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type III restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type III restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032086 ! regulation of type III site-specific deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015668 ! type III site-specific deoxyribonuclease activity relationship: negatively_regulates GO:0015668 ! type III site-specific deoxyribonuclease activity [Term] id: GO:0032083 name: negative regulation of type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type IV restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type IV restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type IV restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032087 ! regulation of type IV site-specific deoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032067 ! type IV site-specific deoxyribonuclease activity relationship: negatively_regulates GO:0032067 ! type IV site-specific deoxyribonuclease activity [Term] id: GO:0032084 name: regulation of type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type I restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type I restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009035 ! type I site-specific deoxyribonuclease activity relationship: regulates GO:0009035 ! type I site-specific deoxyribonuclease activity [Term] id: GO:0032085 name: regulation of type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type II restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type II restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009036 ! type II site-specific deoxyribonuclease activity relationship: regulates GO:0009036 ! type II site-specific deoxyribonuclease activity [Term] id: GO:0032086 name: regulation of type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type III restriction endoribonuclease activity" EXACT [GOC:dph] synonym: "type III restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type III restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015668 ! type III site-specific deoxyribonuclease activity relationship: regulates GO:0015668 ! type III site-specific deoxyribonuclease activity [Term] id: GO:0032087 name: regulation of type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity." [GOC:mah] synonym: "regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type IV restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type IV restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032067 ! type IV site-specific deoxyribonuclease activity relationship: regulates GO:0032067 ! type IV site-specific deoxyribonuclease activity [Term] id: GO:0032088 name: negative regulation of NF-kappaB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "NF-kappaB inhibitor" RELATED [] is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity [Term] id: GO:0032089 name: NACHT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032090 name: Pyrin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] synonym: "DAPIN domain binding" EXACT [] synonym: "PAAD domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005515 ! protein binding relationship: negatively_regulates GO:0005515 ! protein binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005515 ! protein binding relationship: positively_regulates GO:0005515 ! protein binding [Term] id: GO:0032093 name: SAM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] synonym: "Sterile Alpha Motif domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032094 name: response to food namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical [Term] id: GO:0032095 name: regulation of response to food namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032094 ! response to food relationship: regulates GO:0032094 ! response to food [Term] id: GO:0032096 name: negative regulation of response to food namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add] synonym: "down regulation of response to food" EXACT [] synonym: "down-regulation of response to food" EXACT [] synonym: "downregulation of response to food" EXACT [] synonym: "inhibition of response to food" NARROW [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032108 ! negative regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032094 ! response to food relationship: negatively_regulates GO:0032094 ! response to food [Term] id: GO:0032097 name: positive regulation of response to food namespace: biological_process def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add] synonym: "activation of response to food" NARROW [] synonym: "stimulation of response to food" NARROW [] synonym: "up regulation of response to food" EXACT [] synonym: "up-regulation of response to food" EXACT [] synonym: "upregulation of response to food" EXACT [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032109 ! positive regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032094 ! response to food relationship: positively_regulates GO:0032094 ! response to food [Term] id: GO:0032098 name: regulation of appetite namespace: biological_process def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] synonym: "regulation of hunger" RELATED [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0031667 ! response to nutrient levels [Term] id: GO:0032099 name: negative regulation of appetite namespace: biological_process def: "Any process that reduces appetite." [GOC:add] synonym: "appetite suppression" RELATED [] synonym: "down regulation of appetite" EXACT [] synonym: "down-regulation of appetite" EXACT [] synonym: "downregulation of appetite" EXACT [] synonym: "inhibition of appetite" NARROW [] synonym: "negative regulation of hunger" RELATED [] is_a: GO:0032096 ! negative regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032100 name: positive regulation of appetite namespace: biological_process def: "Any process that increases appetite." [GOC:add] synonym: "activation of appetite" NARROW [] synonym: "appetite stimulation" RELATED [] synonym: "positive regulation of hunger" RELATED [] synonym: "stimulation of appetite" NARROW [] synonym: "up regulation of appetite" EXACT [] synonym: "up-regulation of appetite" EXACT [] synonym: "upregulation of appetite" EXACT [] is_a: GO:0032097 ! positive regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009605 ! response to external stimulus relationship: regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009605 ! response to external stimulus relationship: negatively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009605 ! response to external stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032104 name: regulation of response to extracellular stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009991 ! response to extracellular stimulus relationship: regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032105 name: negative regulation of response to extracellular stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] synonym: "down regulation of response to extracellular stimulus" EXACT [] synonym: "down-regulation of response to extracellular stimulus" EXACT [] synonym: "downregulation of response to extracellular stimulus" EXACT [] synonym: "inhibition of response to extracellular stimulus" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009991 ! response to extracellular stimulus relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032106 name: positive regulation of response to extracellular stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] synonym: "activation of response to extracellular stimulus" NARROW [] synonym: "stimulation of response to extracellular stimulus" NARROW [] synonym: "up regulation of response to extracellular stimulus" EXACT [] synonym: "up-regulation of response to extracellular stimulus" EXACT [] synonym: "upregulation of response to extracellular stimulus" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009991 ! response to extracellular stimulus relationship: positively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032107 name: regulation of response to nutrient levels namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] is_a: GO:0032104 ! regulation of response to extracellular stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031667 ! response to nutrient levels relationship: regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032108 name: negative regulation of response to nutrient levels namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "down regulation of response to nutrient levels" EXACT [] synonym: "down-regulation of response to nutrient levels" EXACT [] synonym: "downregulation of response to nutrient levels" EXACT [] synonym: "inhibition of response to nutrient levels" NARROW [] is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031667 ! response to nutrient levels relationship: negatively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032109 name: positive regulation of response to nutrient levels namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "activation of response to nutrient levels" NARROW [] synonym: "stimulation of response to nutrient levels" NARROW [] synonym: "up regulation of response to nutrient levels" EXACT [] synonym: "up-regulation of response to nutrient levels" EXACT [] synonym: "upregulation of response to nutrient levels" EXACT [] is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031667 ! response to nutrient levels relationship: positively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032110 name: regulation of protein histidine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004673 ! protein histidine kinase activity relationship: regulates GO:0004673 ! protein histidine kinase activity [Term] id: GO:0032111 name: activation of protein histidine kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah] synonym: "protein histidine kinase activator" RELATED [] is_a: GO:0010864 ! positive regulation of protein histidine kinase activity is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032112 name: negative regulation of protein histidine kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] synonym: "down regulation of protein histidine kinase activity" EXACT [] synonym: "down-regulation of protein histidine kinase activity" EXACT [] synonym: "downregulation of protein histidine kinase activity" EXACT [] synonym: "inhibition of protein histidine kinase activity" NARROW [] synonym: "protein histidine kinase inhibitor" RELATED [] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0032110 ! regulation of protein histidine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004673 ! protein histidine kinase activity relationship: negatively_regulates GO:0004673 ! protein histidine kinase activity [Term] id: GO:0032113 name: regulation of carbohydrate phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019203 ! carbohydrate phosphatase activity relationship: regulates GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0032114 name: regulation of glucose-6-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp] is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004346 ! glucose-6-phosphatase activity relationship: regulates GO:0004346 ! glucose-6-phosphatase activity [Term] id: GO:0032115 name: sorbose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14609] synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289] synonym: "Sou1p" RELATED [EC:1.1.1.289] xref: EC:1.1.1.289 xref: KEGG_REACTION:R07346 xref: MetaCyc:1.1.1.289-RXN xref: RHEA:14609 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032116 name: SMC loading complex namespace: cellular_component def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] synonym: "chromatin loading complex" RELATED [] synonym: "cohesin loading complex" NARROW [] synonym: "SCC2/SCC4 loading complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032117 name: horsetail-astral microtubule array namespace: cellular_component def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] synonym: "HAA" EXACT [] is_a: GO:0005818 ! aster relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton [Term] id: GO:0032118 name: horsetail-astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah] synonym: "horsetail-astral microtubule array organization" EXACT [] synonym: "horsetail-astral microtubule organisation" EXACT [GOC:mah] synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement [Term] id: GO:0032119 name: sequestering of zinc ion namespace: biological_process def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0006882 ! cellular zinc ion homeostasis [Term] id: GO:0032120 name: ascospore-type prospore membrane assembly namespace: biological_process def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt] synonym: "forespore membrane biosynthesis" EXACT [] synonym: "forespore membrane formation" EXACT [] synonym: "FSM assembly" EXACT [] synonym: "FSM biosynthesis" EXACT [] synonym: "FSM formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0071709 ! membrane assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0031321 ! ascospore-type prospore assembly [Term] id: GO:0032121 name: meiotic attachment of telomeric heterochromatin to spindle pole body namespace: biological_process def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890] synonym: "attachment of telomeres to spindle pole body" BROAD [] synonym: "attachment of telomeric chromatin to spindle pole body" BROAD [] is_a: GO:0007017 ! microtubule-based process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0045141 ! meiotic telomere clustering [Term] id: GO:0032122 name: oral apparatus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830] synonym: "oral apparatus morphogenesis" RELATED [] synonym: "oral apparatus organisation" EXACT [GOC:mah] synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah] synonym: "stomatogenesis" RELATED [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0032123 name: deep fiber namespace: cellular_component def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] synonym: "deep fibre" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0031912 ! oral apparatus [Term] id: GO:0032124 name: macronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "macronuclear organization" EXACT [] synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah] synonym: "macronucleus organisation" EXACT [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032125 name: micronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "micronuclear organization" EXACT [] synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah] synonym: "micronucleus organisation" EXACT [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032126 name: eisosome namespace: cellular_component def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779] xref: Wikipedia:Eisosome is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031045 ! dense core granule [Term] id: GO:0032128 name: flocculation via extracellular polymer namespace: biological_process def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073] synonym: "flocculation via EBF" EXACT [] synonym: "flocculation via extracellular biopolymeric flocculants" EXACT [] is_a: GO:0000128 ! flocculation [Term] id: GO:0032129 name: histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] is_a: GO:0004407 ! histone deacetylase activity relationship: part_of GO:0061647 ! histone H3-K9 modification relationship: part_of GO:1990619 ! histone H3-K9 deacetylation [Term] id: GO:0032130 name: medial membrane band assembly namespace: biological_process def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003] synonym: "medial membrane band formation" RELATED [gOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1902410 ! mitotic cytokinetic process [Term] id: GO:0032131 name: alkylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with alkylated residues in DNA." [GOC:mah] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032132 name: O6-alkylguanine-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453] is_a: GO:0032131 ! alkylated DNA binding [Term] id: GO:0032133 name: chromosome passenger complex namespace: cellular_component def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910] synonym: "chromosomal passenger complex" EXACT [GOC:mcc] synonym: "CPC" BROAD [GOC:mah] synonym: "CPC complex" EXACT [GOC:vw] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0032135 name: DNA insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [GOC:vk] synonym: "DNA insertion binding" NARROW [] synonym: "insertion binding" EXACT [] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032136 name: adenine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair." [GOC:vk] synonym: "A/C mispair binding" EXACT [GOC:bf] synonym: "C/A mispair binding" EXACT [GOC:bf] synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032137 name: guanine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk] synonym: "G/T mispair binding" EXACT [GOC:bf] synonym: "T/G mispair binding" EXACT [GOC:bf] synonym: "thymine/guanine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032138 name: single base insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] synonym: "single base insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032139 name: dinucleotide insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk] synonym: "dinucleotide insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032140 name: single adenine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032141 name: single cytosine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032142 name: single guanine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032143 name: single thymine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032144 name: 4-aminobutyrate transaminase complex namespace: cellular_component def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] synonym: "ABAT complex" EXACT [] synonym: "GABA transaminase complex" EXACT [] synonym: "GABA-T complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032145 name: succinate-semialdehyde dehydrogenase binding namespace: molecular_function def: "Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase." [GOC:mah] synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032147 name: activation of protein kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] synonym: "protein kinase activation" RELATED [] is_a: GO:0045860 ! positive regulation of protein kinase activity [Term] id: GO:0032148 name: activation of protein kinase B activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg] synonym: "protein kinase B activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032149 name: response to rhamnose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg] synonym: "response to L-rhamnose stimulus" NARROW [] synonym: "response to rhamnose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0032150 name: ubiquinone biosynthetic process from chorismate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0032151 name: mitotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032152 name: meiotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032153 name: cell division site namespace: cellular_component def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] comment: Note that this term refers to the future site of division in a cell that has not yet divided. subset: goslim_pir synonym: "cell division plane" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0032154 name: cleavage furrow namespace: cellular_component def: "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] comment: While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. xref: Wikipedia:Cleavage_furrow is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0032155 name: obsolete cell division site part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cell division plane part" EXACT [] is_obsolete: true consider: GO:0032153 [Term] id: GO:0032156 name: septin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0032157 name: prospore contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] synonym: "actomyosin ring" RELATED [] synonym: "cytokinetic ring" RELATED [] synonym: "meiotic contractile ring" RELATED [] is_a: GO:0110086 ! meiotic actomyosin contractile ring intersection_of: GO:0005826 ! actomyosin contractile ring intersection_of: part_of GO:0042764 ! ascospore-type prospore relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032158 name: septin band namespace: cellular_component def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032159 name: septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0032160 name: septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] synonym: "septin bar" RELATED [] is_a: GO:0032156 ! septin cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0032161 name: cleavage apparatus septin structure namespace: cellular_component def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005938 ! cell cortex relationship: part_of GO:0032153 ! cell division site relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032162 name: mating projection septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band intersection_of: GO:0032158 ! septin band intersection_of: part_of GO:0005937 ! mating projection relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032163 name: hyphal septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band [Term] id: GO:0032164 name: hyphal septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap [Term] id: GO:0032165 name: prospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032166 name: chlamydospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032167 name: obsolete septin patch namespace: cellular_component def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555] comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure. synonym: "septin patch" EXACT [] is_obsolete: true [Term] id: GO:0032168 name: hyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032169 name: prospore septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0042764 ! ascospore-type prospore relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032170 name: pseudohyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032171 name: germ tube septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap intersection_of: GO:0032159 ! septin cap intersection_of: part_of GO:0032179 ! germ tube relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032172 name: germ tube septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] is_a: GO:0005940 ! septin ring intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0032179 ! germ tube relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032173 name: septin collar namespace: cellular_component def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0032174 name: cellular bud neck septin collar namespace: cellular_component def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032173 ! septin collar intersection_of: GO:0032173 ! septin collar intersection_of: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0032175 name: mating projection septin ring namespace: cellular_component def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0005937 ! mating projection relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032176 name: split septin rings namespace: cellular_component def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0032177 name: cellular bud neck split septin rings namespace: cellular_component def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032176 ! split septin rings intersection_of: GO:0032176 ! split septin rings intersection_of: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0032178 name: medial membrane band namespace: cellular_component def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] synonym: "sterol-rich membrane band" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0032179 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: Wikipedia:Germ_tube is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0032180 name: ubiquinone biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032181 name: dinucleotide repeat insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] is_a: GO:0032139 ! dinucleotide insertion or deletion binding [Term] id: GO:0032182 name: ubiquitin-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "small conjugating protein binding" EXACT [GOC:dph] is_a: GO:0005515 ! protein binding [Term] id: GO:0032183 name: SUMO binding namespace: molecular_function def: "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 binding" RELATED [] synonym: "Smt3 monomer binding" NARROW [] is_a: GO:0032182 ! ubiquitin-like protein binding [Term] id: GO:0032184 name: SUMO polymer binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 polymer binding" EXACT [] is_a: GO:0032183 ! SUMO binding [Term] id: GO:0032185 name: septin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "septin cytoskeleton organisation" EXACT [GOC:mah] synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0032186 name: cellular bud neck septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] synonym: "cellular bud neck septin ring organisation" EXACT [GOC:mah] is_a: GO:0031106 ! septin ring organization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0007105 ! cytokinesis, site selection [Term] id: GO:0032187 name: actomyosin contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] is_a: GO:0036214 ! contractile ring localization [Term] id: GO:0032188 name: establishment of actomyosin contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah] synonym: "actomyosin ring positioning" RELATED [GOC:mah] synonym: "contractile ring positioning" BROAD [GOC:mah] synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw] synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! actomyosin contractile ring localization relationship: part_of GO:0007105 ! cytokinesis, site selection [Term] id: GO:0032189 name: maintenance of actomyosin contractile ring localization namespace: biological_process def: "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] synonym: "cytokinetic ring anchoring" RELATED [] synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! actomyosin contractile ring localization relationship: part_of GO:0031566 ! actomyosin contractile ring maintenance [Term] id: GO:0032190 name: acrosin binding namespace: molecular_function alt_id: GO:0032191 alt_id: GO:0032192 def: "Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] synonym: "acrosin heavy chain binding" NARROW [] synonym: "acrosin light chain binding" NARROW [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032193 name: ubiquinone biosynthetic process via 2-polyprenylphenol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032194 name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032195 name: post-lysosomal vacuole namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012] synonym: "post-lysosome" EXACT [GOC:dph] is_a: GO:0005773 ! vacuole is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Transposon is_a: GO:0009987 ! cellular process [Term] id: GO:0032197 name: transposition, RNA-mediated namespace: biological_process alt_id: GO:0006319 alt_id: GO:0006320 alt_id: GO:0006321 alt_id: GO:0006322 def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090] synonym: "Class I transposition" EXACT [] synonym: "retrotransposition" EXACT [] synonym: "retrotransposon transposition" EXACT [] synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb] synonym: "Tf transposition" NARROW [] synonym: "Ty element transposition" NARROW [] synonym: "Ty1 element transposition" NARROW [] synonym: "Ty2 element transposition" NARROW [] synonym: "Ty3 element transposition" NARROW [] xref: Wikipedia:Transposon##Class_I\:_Retrotransposons is_a: GO:0032196 ! transposition [Term] id: GO:0032198 name: MITE transposition namespace: biological_process def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090] synonym: "Class III transposition" EXACT [] is_a: GO:0032196 ! transposition [Term] id: GO:0032199 name: reverse transcription involved in RNA-mediated transposition namespace: biological_process def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090] synonym: "reverse transcription during retrotransposition" EXACT [] is_a: GO:0001171 ! reverse transcription intersection_of: GO:0001171 ! reverse transcription intersection_of: part_of GO:0032197 ! transposition, RNA-mediated relationship: part_of GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0032200 name: telomere organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe subset: goslim_yeast synonym: "chromosome organization, telomeric" EXACT [] synonym: "organization of chromosome, telomeric region" EXACT [] synonym: "telomere organisation" EXACT [GOC:mah] synonym: "telomere organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0032201 name: telomere maintenance via semi-conservative replication namespace: biological_process def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication." [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261] synonym: "equal telomere replication" RELATED [] synonym: "telomeric fork progression" NARROW [] synonym: "telomeric replication fork progression" NARROW [] is_a: GO:0000723 ! telomere maintenance is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0033260 ! nuclear DNA replication [Term] id: GO:0032202 name: telomere assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671] synonym: "telomere formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032200 ! telomere organization [Term] id: GO:0032203 name: telomere formation via telomerase namespace: biological_process def: "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme." [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671] is_a: GO:0032202 ! telomere assembly relationship: has_part GO:0003720 ! telomerase activity relationship: has_part GO:1905324 ! telomere-telomerase complex assembly [Term] id: GO:0032204 name: regulation of telomere maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000723 ! telomere maintenance relationship: regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032205 name: negative regulation of telomere maintenance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance" EXACT [] synonym: "down-regulation of telomere maintenance" EXACT [] synonym: "downregulation of telomere maintenance" EXACT [] synonym: "inhibition of telomere maintenance" NARROW [] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000723 ! telomere maintenance relationship: negatively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032206 name: positive regulation of telomere maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance" NARROW [] synonym: "stimulation of telomere maintenance" NARROW [] synonym: "up regulation of telomere maintenance" EXACT [] synonym: "up-regulation of telomere maintenance" EXACT [] synonym: "upregulation of telomere maintenance" EXACT [] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000723 ! telomere maintenance relationship: positively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032207 name: regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0072695 ! regulation of DNA recombination at telomere intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000722 ! telomere maintenance via recombination relationship: regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032208 name: negative regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "down regulation of telomere maintenance via recombination" EXACT [] synonym: "down-regulation of telomere maintenance via recombination" EXACT [] synonym: "downregulation of telomere maintenance via recombination" EXACT [] synonym: "inhibition of telomere maintenance via recombination" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045950 ! negative regulation of mitotic recombination is_a: GO:0048239 ! negative regulation of DNA recombination at telomere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000722 ! telomere maintenance via recombination relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032209 name: positive regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "activation of telomere maintenance via recombination" NARROW [] synonym: "stimulation of telomere maintenance via recombination" NARROW [] synonym: "up regulation of telomere maintenance via recombination" EXACT [] synonym: "up-regulation of telomere maintenance via recombination" EXACT [] synonym: "upregulation of telomere maintenance via recombination" EXACT [] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045951 ! positive regulation of mitotic recombination is_a: GO:0072696 ! positive regulation of DNA recombination at telomere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000722 ! telomere maintenance via recombination relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032210 name: regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007004 ! telomere maintenance via telomerase relationship: regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032211 name: negative regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "down regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "downregulation of telomere maintenance via telomerase activity" EXACT [] synonym: "inhibition of telomere maintenance via telomerase" NARROW [] is_a: GO:0032210 ! regulation of telomere maintenance via telomerase is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007004 ! telomere maintenance via telomerase relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032212 name: positive regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "activation of telomere maintenance via telomerase" NARROW [] synonym: "stimulation of telomere maintenance via telomerase" NARROW [] synonym: "up regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "upregulation of telomere maintenance via telomerase activity" EXACT [] is_a: GO:0032210 ! regulation of telomere maintenance via telomerase is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007004 ! telomere maintenance via telomerase relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032213 name: regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032201 ! telomere maintenance via semi-conservative replication relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032214 name: negative regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032215 name: positive regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT [] is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032216 name: glucosaminyl-phosphatidylinositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA." [Reactome:R-HSA-162683] synonym: "glucosaminyl-phosphotidylinositol O-acyltransferase activity" EXACT [] synonym: "GPI-inositol acyltransferase" RELATED [] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032217 name: riboflavin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] synonym: "riboflavin transporter activity" RELATED [] xref: Reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0032218 ! riboflavin transport [Term] id: GO:0032218 name: riboflavin transport namespace: biological_process def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] is_a: GO:0015711 ! organic anion transport is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0032219 name: cell wall macromolecule catabolic process involved in cytogamy namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah] synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0016998 ! cell wall macromolecule catabolic process is_a: GO:0022414 ! reproductive process intersection_of: GO:0016998 ! cell wall macromolecule catabolic process intersection_of: part_of GO:0000755 ! cytogamy relationship: part_of GO:0000755 ! cytogamy [Term] id: GO:0032220 name: plasma membrane fusion involved in cytogamy namespace: biological_process alt_id: GO:0070872 def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah, PMID:29134248] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/16258 synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb] synonym: "plasma membrane organization involved in conjugation with cellular fusion" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0045026 ! plasma membrane fusion intersection_of: GO:0045026 ! plasma membrane fusion intersection_of: part_of GO:0000755 ! cytogamy relationship: part_of GO:0000755 ! cytogamy created_by: midori creation_date: 2009-08-20T02:24:56Z [Term] id: GO:0032221 name: Rpd3S complex namespace: cellular_component alt_id: GO:0000509 def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw] synonym: "Clr6S complex" EXACT [PMID:19040720] synonym: "Rpd3C(S)" EXACT [] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007271 ! synaptic transmission, cholinergic relationship: regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007271 ! synaptic transmission, cholinergic relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032225 name: regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001963 ! synaptic transmission, dopaminergic relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032226 name: positive regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "activation of synaptic transmission, dopaminergic" NARROW [] synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032227 name: negative regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032228 name: regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051932 ! synaptic transmission, GABAergic relationship: regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032229 name: negative regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032230 name: positive regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "activation of synaptic transmission, GABAergic" NARROW [] synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051932 ! synaptic transmission, GABAergic relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110053 ! regulation of actin filament organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051017 ! actin filament bundle assembly relationship: regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051017 ! actin filament bundle assembly relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051017 ! actin filament bundle assembly relationship: positively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032234 name: obsolete regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "regulation of store-operated calcium channel activity" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032235 name: obsolete negative regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "negative regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "negative regulation of store-operated calcium channel activity" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032236 name: obsolete positive regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "positive regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "positive regulation of store-operated calcium channel activity" EXACT [] synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032237 name: activation of store-operated calcium channel activity namespace: biological_process def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah] is_a: GO:1901341 ! positive regulation of store-operated calcium channel activity [Term] id: GO:0032238 name: adenosine transport namespace: biological_process def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015858 ! nucleoside transport is_a: GO:0015893 ! drug transport [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015931 ! nucleobase-containing compound transport relationship: regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015931 ! nucleobase-containing compound transport relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015931 ! nucleobase-containing compound transport relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032242 name: regulation of nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015858 ! nucleoside transport relationship: regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032243 name: negative regulation of nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleoside transport" EXACT [] synonym: "down-regulation of nucleoside transport" EXACT [] synonym: "downregulation of nucleoside transport" EXACT [] synonym: "inhibition of nucleoside transport" NARROW [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0032242 ! regulation of nucleoside transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015858 ! nucleoside transport relationship: negatively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032244 name: positive regulation of nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleoside transport" NARROW [] synonym: "stimulation of nucleoside transport" NARROW [] synonym: "up regulation of nucleoside transport" EXACT [] synonym: "up-regulation of nucleoside transport" EXACT [] synonym: "upregulation of nucleoside transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0032242 ! regulation of nucleoside transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015858 ! nucleoside transport relationship: positively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032245 name: regulation of purine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport [Term] id: GO:0032246 name: regulation of pyrimidine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015864 ! pyrimidine nucleoside transport relationship: regulates GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0032247 name: negative regulation of purine nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of purine nucleoside transport" EXACT [] synonym: "down-regulation of purine nucleoside transport" EXACT [] synonym: "downregulation of purine nucleoside transport" EXACT [] synonym: "inhibition of purine nucleoside transport" NARROW [] is_a: GO:0032243 ! negative regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport [Term] id: GO:0032248 name: positive regulation of purine nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of purine nucleoside transport" NARROW [] synonym: "stimulation of purine nucleoside transport" NARROW [] synonym: "up regulation of purine nucleoside transport" EXACT [] synonym: "up-regulation of purine nucleoside transport" EXACT [] synonym: "upregulation of purine nucleoside transport" EXACT [] is_a: GO:0032244 ! positive regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport [Term] id: GO:0032249 name: regulation of adenosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032245 ! regulation of purine nucleoside transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032238 ! adenosine transport relationship: regulates GO:0032238 ! adenosine transport [Term] id: GO:0032250 name: negative regulation of adenosine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of adenosine transport" EXACT [] synonym: "down-regulation of adenosine transport" EXACT [] synonym: "downregulation of adenosine transport" EXACT [] synonym: "inhibition of adenosine transport" NARROW [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032238 ! adenosine transport relationship: negatively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032251 name: positive regulation of adenosine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of adenosine transport" NARROW [] synonym: "stimulation of adenosine transport" NARROW [] synonym: "up regulation of adenosine transport" EXACT [] synonym: "up-regulation of adenosine transport" EXACT [] synonym: "upregulation of adenosine transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032238 ! adenosine transport relationship: positively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization [Term] id: GO:0032254 name: establishment of secretory granule localization namespace: biological_process def: "The directed movement of a secretory granule to a specific location." [GOC:mah] synonym: "establishment of secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032255 name: maintenance of secretory granule location namespace: biological_process def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051655 ! maintenance of vesicle location relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032256 name: establishment of dense core granule localization namespace: biological_process def: "The directed movement of a dense core granule to a specific location." [GOC:mah] synonym: "establishment of dense core granule localisation" EXACT [GOC:mah] synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032254 ! establishment of secretory granule localization relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032257 name: maintenance of dense core granule location namespace: biological_process def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv] is_a: GO:0032255 ! maintenance of secretory granule location relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032258 name: cytoplasm to vacuole transport by the Cvt pathway namespace: biological_process def: "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] synonym: "cytoplasm to vacuole targeting" BROAD [] synonym: "cytoplasm-to-vacuole targeting" BROAD [] synonym: "protein localization by the Cvt pathway" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0061919 ! process utilizing autophagic mechanism relationship: has_part GO:0006624 ! vacuolar protein processing [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0032260 name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah] synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] is_a: GO:0009753 ! response to jasmonic acid intersection_of: GO:0009753 ! response to jasmonic acid intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0032261 name: purine nucleotide salvage namespace: biological_process def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032262 name: pyrimidine nucleotide salvage namespace: biological_process def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032263 name: GMP salvage namespace: biological_process def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0006177 ! GMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032264 name: IMP salvage namespace: biological_process def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006188 ! IMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032265 name: XMP salvage namespace: biological_process def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0032261 ! purine nucleotide salvage is_a: GO:0097293 ! XMP biosynthetic process [Term] id: GO:0032266 name: phosphatidylinositol-3-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] synonym: "phosphatidylinositol 3-phosphate binding" EXACT [] synonym: "PtdIns-3-P binding" EXACT [] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0032267 name: tRNA(Ile)-lysidine synthase activity namespace: molecular_function def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] xref: EC:6.3.4 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044267 ! cellular protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044267 ! cellular protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044267 ! cellular protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051258 ! protein polymerization relationship: regulates GO:0051258 ! protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051258 ! protein polymerization relationship: negatively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051258 ! protein polymerization relationship: positively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032274 name: gonadotropin secretion namespace: biological_process def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544] synonym: "gonadotrophin secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion namespace: biological_process def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032276 name: regulation of gonadotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "regulation of gonadotrophin secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032274 ! gonadotropin secretion relationship: regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032277 name: negative regulation of gonadotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "down regulation of gonadotropin secretion" EXACT [] synonym: "down-regulation of gonadotropin secretion" EXACT [] synonym: "downregulation of gonadotropin secretion" EXACT [] synonym: "inhibition of gonadotropin secretion" NARROW [] synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032274 ! gonadotropin secretion relationship: negatively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032278 name: positive regulation of gonadotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "activation of gonadotropin secretion" NARROW [] synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph] synonym: "stimulation of gonadotropin secretion" NARROW [] synonym: "up regulation of gonadotropin secretion" EXACT [] synonym: "up-regulation of gonadotropin secretion" EXACT [] synonym: "upregulation of gonadotropin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032274 ! gonadotropin secretion relationship: positively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032279 name: asymmetric synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] synonym: "Gray's type I synapse" EXACT [] is_a: GO:0098984 ! neuron to neuron synapse intersection_of: GO:0098984 ! neuron to neuron synapse intersection_of: has_part GO:0014069 ! postsynaptic density disjoint_from: GO:0032280 ! symmetric synapse relationship: has_part GO:0014069 ! postsynaptic density [Term] id: GO:0032280 name: symmetric synapse namespace: cellular_component def: "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory." [GOC:dgh, GOC:ef] comment: The term 'symmetric' in this name refers only to gross morphology. There is no implication of functional symmetry. synonym: "Gray's type II synapse" EXACT [] is_a: GO:0098984 ! neuron to neuron synapse [Term] id: GO:0032281 name: AMPA glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex" EXACT [] synonym: "AMPA receptor" RELATED [] synonym: "AMPA-selective glutamate receptor complex" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034703 ! cation channel complex [Term] id: GO:0032282 name: plastid acetyl-CoA carboxylase complex namespace: cellular_component def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] synonym: "plastid ACCase complex" EXACT [] is_a: GO:0009317 ! acetyl-CoA carboxylase complex relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0032283 name: plastid acetate CoA-transferase complex namespace: cellular_component def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009329 ! acetate CoA-transferase complex relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032284 name: plastid biotin carboxylase complex namespace: cellular_component def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009343 ! biotin carboxylase complex intersection_of: GO:0009343 ! biotin carboxylase complex intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032285 name: non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh] synonym: "ensheathment of non-myelinated axons" EXACT [] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032286 name: central nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in central nervous system" EXACT [] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032287 name: peripheral nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in peripheral nervous system" EXACT [] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032288 name: myelin assembly namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0042552 ! myelination [Term] id: GO:0032289 name: central nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] synonym: "myelin formation in central nervous system" EXACT [] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032290 name: peripheral nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh] synonym: "myelin formation in peripheral nervous system" EXACT [] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032291 name: axon ensheathment in central nervous system namespace: biological_process def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in central nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032292 name: peripheral nervous system axon ensheathment namespace: biological_process def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in peripheral nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032293 name: non-myelinated axon ensheathment in central nervous system namespace: biological_process def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT [] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032291 ! axon ensheathment in central nervous system [Term] id: GO:0032294 name: peripheral nervous system non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT [] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032292 ! peripheral nervous system axon ensheathment [Term] id: GO:0032295 name: ensheathment of neuronal cell bodies namespace: biological_process def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0032296 name: double-stranded RNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] synonym: "double-stranded RNA-specific RNase activity" EXACT [] synonym: "dsRNA-specific ribonuclease activity" EXACT [] synonym: "dsRNA-specific RNase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0032297 name: negative regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "down regulation of DNA replication initiation" EXACT [] synonym: "down-regulation of DNA replication initiation" EXACT [] synonym: "downregulation of DNA replication initiation" EXACT [] synonym: "inhibition of DNA replication initiation" NARROW [] synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006270 ! DNA replication initiation relationship: negatively_regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0032298 name: positive regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "activation of DNA replication initiation" NARROW [] synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] synonym: "stimulation of DNA replication initiation" NARROW [] synonym: "up regulation of DNA replication initiation" EXACT [] synonym: "up-regulation of DNA replication initiation" EXACT [] synonym: "upregulation of DNA replication initiation" EXACT [] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006270 ! DNA replication initiation relationship: positively_regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0032299 name: ribonuclease H2 complex namespace: cellular_component def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] synonym: "RNase H2 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032300 name: mismatch repair complex namespace: cellular_component def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] subset: goslim_pir is_a: GO:1990391 ! DNA repair complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032301 name: MutSalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH6 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032302 name: MutSbeta complex namespace: cellular_component def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH3 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032303 name: regulation of icosanoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "regulation of eicosanoid secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032309 ! icosanoid secretion relationship: regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032304 name: negative regulation of icosanoid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "down regulation of icosanoid secretion" EXACT [] synonym: "down-regulation of icosanoid secretion" EXACT [] synonym: "downregulation of icosanoid secretion" EXACT [] synonym: "inhibition of icosanoid secretion" NARROW [] synonym: "negative regulation of eicosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:2000192 ! negative regulation of fatty acid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032309 ! icosanoid secretion relationship: negatively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032305 name: positive regulation of icosanoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "activation of icosanoid secretion" NARROW [] synonym: "positive regulation of eicosanoid secretion" EXACT [] synonym: "stimulation of icosanoid secretion" NARROW [] synonym: "up regulation of icosanoid secretion" EXACT [] synonym: "up-regulation of icosanoid secretion" EXACT [] synonym: "upregulation of icosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:2000193 ! positive regulation of fatty acid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032309 ! icosanoid secretion relationship: positively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032306 name: regulation of prostaglandin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "regulation of prostacyclin secretion" NARROW [] is_a: GO:0032303 ! regulation of icosanoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032310 ! prostaglandin secretion relationship: regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032307 name: negative regulation of prostaglandin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "down regulation of prostaglandin secretion" EXACT [] synonym: "down-regulation of prostaglandin secretion" EXACT [] synonym: "downregulation of prostaglandin secretion" EXACT [] synonym: "inhibition of prostaglandin secretion" NARROW [] synonym: "negative regulation of prostacyclin secretion" NARROW [] is_a: GO:0032304 ! negative regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032310 ! prostaglandin secretion relationship: negatively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032308 name: positive regulation of prostaglandin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "activation of prostaglandin secretion" NARROW [] synonym: "positive regulation of prostacyclin secretion" NARROW [] synonym: "stimulation of prostaglandin secretion" NARROW [] synonym: "up regulation of prostaglandin secretion" EXACT [] synonym: "up-regulation of prostaglandin secretion" EXACT [] synonym: "upregulation of prostaglandin secretion" EXACT [] is_a: GO:0032305 ! positive regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032310 ! prostaglandin secretion relationship: positively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032309 name: icosanoid secretion namespace: biological_process def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah] synonym: "eicosanoid secretion" EXACT [] is_a: GO:0046717 ! acid secretion is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0032310 name: prostaglandin secretion namespace: biological_process def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue." [GOC:mah] synonym: "prostacyclin secretion" NARROW [] is_a: GO:0015732 ! prostaglandin transport is_a: GO:0032309 ! icosanoid secretion [Term] id: GO:0032311 name: angiogenin-PRI complex namespace: cellular_component def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0032322 name: ubiquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "ubiquinone breakdown" EXACT [] synonym: "ubiquinone catabolism" EXACT [] synonym: "ubiquinone degradation" EXACT [] is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:1901662 ! quinone catabolic process [Term] id: GO:0032323 name: lipoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah] synonym: "lipoic acid breakdown" EXACT [] synonym: "lipoic acid catabolism" EXACT [] synonym: "lipoic acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0032324 name: molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "molybdopterin cofactor anabolism" EXACT [] synonym: "molybdopterin cofactor biosynthesis" RELATED [] synonym: "molybdopterin cofactor formation" RELATED [] synonym: "molybdopterin cofactor synthesis" EXACT [] xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: has_part GO:0030366 ! molybdopterin synthase activity relationship: has_part GO:0031071 ! cysteine desulfurase activity relationship: has_part GO:0061598 ! molybdopterin adenylyltransferase activity relationship: has_part GO:0061604 ! molybdopterin-synthase sulfurtransferase activity relationship: has_part GO:0061605 ! molybdopterin-synthase adenylyltransferase activity [Term] id: GO:0032325 name: molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0032326 name: Mo-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "Mo-molybdopterin cofactor breakdown" EXACT [] synonym: "Mo-molybdopterin cofactor catabolism" EXACT [] synonym: "Mo-molybdopterin cofactor degradation" EXACT [] synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process [Term] id: GO:0032327 name: W-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] synonym: "W-molybdopterin cofactor breakdown" EXACT [] synonym: "W-molybdopterin cofactor catabolism" EXACT [] synonym: "W-molybdopterin cofactor degradation" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process [Term] id: GO:0032328 name: alanine transport namespace: biological_process def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0032329 name: serine transport namespace: biological_process alt_id: GO:0090478 def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "serine import" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002062 ! chondrocyte differentiation relationship: regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061037 ! negative regulation of cartilage development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002062 ! chondrocyte differentiation relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0061036 ! positive regulation of cartilage development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002062 ! chondrocyte differentiation relationship: positively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032333 name: activin secretion namespace: biological_process def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah] is_a: GO:0046879 ! hormone secretion [Term] id: GO:0032334 name: inhibin secretion namespace: biological_process def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032335 name: regulation of activin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032333 ! activin secretion relationship: regulates GO:0032333 ! activin secretion [Term] id: GO:0032336 name: negative regulation of activin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] synonym: "down regulation of activin secretion" EXACT [] synonym: "down-regulation of activin secretion" EXACT [] synonym: "downregulation of activin secretion" EXACT [] synonym: "inhibition of activin secretion" NARROW [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046888 ! negative regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032333 ! activin secretion relationship: negatively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032337 name: positive regulation of activin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] synonym: "activation of activin secretion" NARROW [] synonym: "stimulation of activin secretion" NARROW [] synonym: "up regulation of activin secretion" EXACT [] synonym: "up-regulation of activin secretion" EXACT [] synonym: "upregulation of activin secretion" EXACT [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046887 ! positive regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032333 ! activin secretion relationship: positively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032338 name: regulation of inhibin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032334 ! inhibin secretion relationship: regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032339 name: negative regulation of inhibin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] synonym: "down regulation of inhibin secretion" EXACT [] synonym: "down-regulation of inhibin secretion" EXACT [] synonym: "downregulation of inhibin secretion" EXACT [] synonym: "inhibition of inhibin secretion" NARROW [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032334 ! inhibin secretion relationship: negatively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032340 name: positive regulation of inhibin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] synonym: "activation of inhibin secretion" NARROW [] synonym: "stimulation of inhibin secretion" NARROW [] synonym: "up regulation of inhibin secretion" EXACT [] synonym: "up-regulation of inhibin secretion" EXACT [] synonym: "upregulation of inhibin secretion" EXACT [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032334 ! inhibin secretion relationship: positively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032341 name: aldosterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] synonym: "aldosterone metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0032342 name: aldosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0006705 ! mineralocorticoid biosynthetic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0032343 name: aldosterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006712 ! mineralocorticoid catabolic process is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0032344 name: regulation of aldosterone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "regulation of aldosterone metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032341 ! aldosterone metabolic process relationship: regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032345 name: negative regulation of aldosterone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "down regulation of aldosterone metabolic process" EXACT [] synonym: "down-regulation of aldosterone metabolic process" EXACT [] synonym: "downregulation of aldosterone metabolic process" EXACT [] synonym: "inhibition of aldosterone metabolic process" NARROW [] synonym: "negative regulation of aldosterone metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032341 ! aldosterone metabolic process relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032346 name: positive regulation of aldosterone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "activation of aldosterone metabolic process" NARROW [] synonym: "positive regulation of aldosterone metabolism" EXACT [] synonym: "stimulation of aldosterone metabolic process" NARROW [] synonym: "up regulation of aldosterone metabolic process" EXACT [] synonym: "up-regulation of aldosterone metabolic process" EXACT [] synonym: "upregulation of aldosterone metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032341 ! aldosterone metabolic process relationship: positively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032347 name: regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032342 ! aldosterone biosynthetic process relationship: regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032348 name: negative regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "down regulation of aldosterone biosynthetic process" EXACT [] synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] synonym: "downregulation of aldosterone biosynthetic process" EXACT [] synonym: "inhibition of aldosterone biosynthetic process" NARROW [] is_a: GO:0032345 ! negative regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032342 ! aldosterone biosynthetic process relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032349 name: positive regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "activation of aldosterone biosynthetic process" NARROW [] synonym: "stimulation of aldosterone biosynthetic process" NARROW [] synonym: "up regulation of aldosterone biosynthetic process" EXACT [] synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] synonym: "upregulation of aldosterone biosynthetic process" EXACT [] is_a: GO:0032346 ! positive regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032342 ! aldosterone biosynthetic process relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042445 ! hormone metabolic process relationship: regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042445 ! hormone metabolic process relationship: negatively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042445 ! hormone metabolic process relationship: positively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032353 name: negative regulation of hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "down regulation of hormone biosynthetic process" EXACT [] synonym: "down-regulation of hormone biosynthetic process" EXACT [] synonym: "downregulation of hormone biosynthetic process" EXACT [] synonym: "inhibition of hormone biosynthetic process" NARROW [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042446 ! hormone biosynthetic process relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0032354 name: response to follicle-stimulating hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] synonym: "response to follicle stimulating hormone stimulus" EXACT [] synonym: "response to follicle-stimulating hormone stimulus" EXACT [GOC:dos] synonym: "response to FSH stimulus" EXACT [] is_a: GO:0034698 ! response to gonadotropin [Term] id: GO:0032355 name: response to estradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] synonym: "response to E2 stimulus" EXACT [] synonym: "response to estradiol stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032356 name: oxidized DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized residues in DNA." [GOC:vk] synonym: "oxidised DNA binding" EXACT [] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032357 name: oxidized purine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized purine residues in DNA." [GOC:vk] synonym: "oxidised purine DNA binding" EXACT [] synonym: "oxidized purine base DNA binding" EXACT [] synonym: "oxidized purine nucleobase DNA binding" EXACT [] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032358 name: oxidized pyrimidine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA." [GOC:vk] synonym: "oxidised pyrimidine DNA binding" EXACT [] synonym: "oxidized pyrimidine base DNA binding" EXACT [] synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT [] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032359 name: provirus excision namespace: biological_process def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] synonym: "prophage excision" EXACT [] is_a: GO:0019046 ! release from viral latency [Term] id: GO:0032361 name: pyridoxal phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042820 ! vitamin B6 catabolic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0032362 name: obsolete FAD catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "FAD breakdown" EXACT [GOC:mah] synonym: "FAD catabolism" EXACT [GOC:mah] synonym: "FAD degradation" EXACT [GOC:mah] synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0032363 name: FMN catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009261 ! ribonucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0032364 name: oxygen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell." [GOC:rph] is_a: GO:0033483 ! gas homeostasis [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0032366 name: intracellular sterol transport namespace: biological_process def: "The directed movement of sterols within cells." [GOC:mah] is_a: GO:0015918 ! sterol transport is_a: GO:0032365 ! intracellular lipid transport intersection_of: GO:0015918 ! sterol transport intersection_of: occurs_in GO:0005622 ! intracellular [Term] id: GO:0032367 name: intracellular cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0032366 ! intracellular sterol transport intersection_of: GO:0030301 ! cholesterol transport intersection_of: occurs_in GO:0005622 ! intracellular [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006869 ! lipid transport relationship: regulates GO:0006869 ! lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006869 ! lipid transport relationship: negatively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006869 ! lipid transport relationship: positively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032371 name: regulation of sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015918 ! sterol transport relationship: regulates GO:0015918 ! sterol transport [Term] id: GO:0032372 name: negative regulation of sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of sterol transport" EXACT [] synonym: "down-regulation of sterol transport" EXACT [] synonym: "downregulation of sterol transport" EXACT [] synonym: "inhibition of sterol transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015918 ! sterol transport relationship: negatively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032373 name: positive regulation of sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of sterol transport" NARROW [] synonym: "stimulation of sterol transport" NARROW [] synonym: "up regulation of sterol transport" EXACT [] synonym: "up-regulation of sterol transport" EXACT [] synonym: "upregulation of sterol transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015918 ! sterol transport relationship: positively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032374 name: regulation of cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030301 ! cholesterol transport relationship: regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032375 name: negative regulation of cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of cholesterol transport" EXACT [] synonym: "down-regulation of cholesterol transport" EXACT [] synonym: "downregulation of cholesterol transport" EXACT [] synonym: "inhibition of cholesterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030301 ! cholesterol transport relationship: negatively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032376 name: positive regulation of cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of cholesterol transport" NARROW [] synonym: "stimulation of cholesterol transport" NARROW [] synonym: "up regulation of cholesterol transport" EXACT [] synonym: "up-regulation of cholesterol transport" EXACT [] synonym: "upregulation of cholesterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030301 ! cholesterol transport relationship: positively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032365 ! intracellular lipid transport relationship: regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032365 ! intracellular lipid transport relationship: negatively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032365 ! intracellular lipid transport relationship: positively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032380 name: regulation of intracellular sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport is_a: GO:0032377 ! regulation of intracellular lipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032366 ! intracellular sterol transport relationship: regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032381 name: negative regulation of intracellular sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "down regulation of intracellular sterol transport" EXACT [] synonym: "down-regulation of intracellular sterol transport" EXACT [] synonym: "downregulation of intracellular sterol transport" EXACT [] synonym: "inhibition of intracellular sterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032378 ! negative regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032366 ! intracellular sterol transport relationship: negatively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032382 name: positive regulation of intracellular sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "activation of intracellular sterol transport" NARROW [] synonym: "stimulation of intracellular sterol transport" NARROW [] synonym: "up regulation of intracellular sterol transport" EXACT [] synonym: "up-regulation of intracellular sterol transport" EXACT [] synonym: "upregulation of intracellular sterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032379 ! positive regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032366 ! intracellular sterol transport relationship: positively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032383 name: regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0032380 ! regulation of intracellular sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032367 ! intracellular cholesterol transport relationship: regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032384 name: negative regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "down regulation of intracellular cholesterol transport" EXACT [] synonym: "down-regulation of intracellular cholesterol transport" EXACT [] synonym: "downregulation of intracellular cholesterol transport" EXACT [] synonym: "inhibition of intracellular cholesterol transport" NARROW [] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0032381 ! negative regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032367 ! intracellular cholesterol transport relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032385 name: positive regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "activation of intracellular cholesterol transport" NARROW [] synonym: "stimulation of intracellular cholesterol transport" NARROW [] synonym: "up regulation of intracellular cholesterol transport" EXACT [] synonym: "up-regulation of intracellular cholesterol transport" EXACT [] synonym: "upregulation of intracellular cholesterol transport" EXACT [] is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:0032382 ! positive regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032367 ! intracellular cholesterol transport relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046907 ! intracellular transport relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046907 ! intracellular transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046907 ! intracellular transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032389 name: MutLalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] synonym: "MLH1/PMS2 complex" EXACT [] synonym: "MMR complex" BROAD [] synonym: "MutL-alpha complex" EXACT [CORUM:292] is_a: GO:0032300 ! mismatch repair complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032390 name: MutLbeta complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] synonym: "MLH1/PMS1 complex" EXACT [] synonym: "MMR complex" BROAD [] is_a: GO:0032300 ! mismatch repair complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032391 name: photoreceptor connecting cilium namespace: cellular_component def: "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680] synonym: "photoreceptor cilium" RELATED [] is_a: GO:0035869 ! ciliary transition zone relationship: part_of GO:0097733 ! photoreceptor cell cilium [Term] id: GO:0032392 name: DNA geometric change namespace: biological_process def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. subset: goslim_pir is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0032393 name: MHC class I receptor activity namespace: molecular_function def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0042288 ! MHC class I protein binding [Term] id: GO:0032394 name: MHC class Ib receptor activity namespace: molecular_function def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0023029 ! MHC class Ib protein binding [Term] id: GO:0032395 name: MHC class II receptor activity namespace: molecular_function def: "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: has_part GO:0042289 ! MHC class II protein binding [Term] id: GO:0032396 name: inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032397 name: activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032398 name: MHC class Ib protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0032399 name: HECT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032400 name: melanosome localization namespace: biological_process def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] synonym: "melanosome localisation" EXACT [GOC:mah] is_a: GO:0051875 ! pigment granule localization [Term] id: GO:0032401 name: establishment of melanosome localization namespace: biological_process def: "The directed movement of a melanosome to a specific location." [GOC:mah] synonym: "establishment of melanosome localisation" EXACT [GOC:mah] is_a: GO:0051905 ! establishment of pigment granule localization relationship: part_of GO:0032400 ! melanosome localization [Term] id: GO:0032402 name: melanosome transport namespace: biological_process def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] is_a: GO:0032400 ! melanosome localization is_a: GO:0032401 ! establishment of melanosome localization is_a: GO:0051904 ! pigment granule transport [Term] id: GO:0032404 name: mismatch repair complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mismatch repair complex." [GOC:vk] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0032405 name: MutLalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032406 name: MutLbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032407 name: MutSalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032408 name: MutSbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005215 ! transporter activity relationship: regulates GO:0005215 ! transporter activity [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005215 ! transporter activity relationship: negatively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005215 ! transporter activity relationship: positively_regulates GO:0005215 ! transporter activity [Term] id: GO:0032412 name: regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0034765 ! regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015075 ! ion transmembrane transporter activity relationship: regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034766 ! negative regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015075 ! ion transmembrane transporter activity relationship: negatively_regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034767 ! positive regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015075 ! ion transmembrane transporter activity relationship: positively_regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032415 name: regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport] synonym: "regulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0010155 ! regulation of proton transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015385 ! sodium:proton antiporter activity relationship: regulates GO:0015385 ! sodium:proton antiporter activity [Term] id: GO:0032416 name: negative regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW [] synonym: "negative regulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0032415 ! regulation of sodium:proton antiporter activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015385 ! sodium:proton antiporter activity relationship: negatively_regulates GO:0015385 ! sodium:proton antiporter activity [Term] id: GO:0032417 name: positive regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "activation of sodium:hydrogen antiporter activity" NARROW [] synonym: "positive regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW [] synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0032415 ! regulation of sodium:proton antiporter activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015385 ! sodium:proton antiporter activity relationship: positively_regulates GO:0015385 ! sodium:proton antiporter activity [Term] id: GO:0032418 name: lysosome localization namespace: biological_process def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0032419 name: extrinsic component of lysosome membrane namespace: cellular_component def: "The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to lysosomal membrane" EXACT [] synonym: "extrinsic to lysosome membrane" EXACT [] is_a: GO:0000306 ! extrinsic component of vacuolar membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005765 ! lysosomal membrane relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0032420 name: stereocilium namespace: cellular_component def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] is_a: GO:0043005 ! neuron projection is_a: GO:0098858 ! actin-based cell projection relationship: part_of GO:0032421 ! stereocilium bundle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0032421 name: stereocilium bundle namespace: cellular_component def: "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] subset: goslim_pir synonym: "stereocilia bundle" EXACT [] is_a: GO:0098862 ! cluster of actin-based cell projections relationship: has_part GO:0032420 ! stereocilium [Term] id: GO:0032422 name: purine-rich negative regulatory element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] synonym: "PNR element binding" BROAD [] is_a: GO:0044212 ! transcription regulatory region DNA binding is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0032423 name: regulation of mismatch repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk] is_a: GO:0006282 ! regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006298 ! mismatch repair relationship: regulates GO:0006298 ! mismatch repair [Term] id: GO:0032424 name: negative regulation of mismatch repair namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "down regulation of mismatch repair" EXACT [] synonym: "down-regulation of mismatch repair" EXACT [] synonym: "downregulation of mismatch repair" EXACT [] synonym: "inhibition of mismatch repair" NARROW [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045738 ! negative regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006298 ! mismatch repair relationship: negatively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032425 name: positive regulation of mismatch repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "activation of mismatch repair" NARROW [] synonym: "stimulation of mismatch repair" NARROW [] synonym: "up regulation of mismatch repair" EXACT [] synonym: "up-regulation of mismatch repair" EXACT [] synonym: "upregulation of mismatch repair" EXACT [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045739 ! positive regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006298 ! mismatch repair relationship: positively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032426 name: stereocilium tip namespace: cellular_component def: "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032420 ! stereocilium [Term] id: GO:0032427 name: GBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069] synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069] synonym: "CRIB motif binding" EXACT [PMID:9119069] synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl] synonym: "PMD binding" EXACT [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032428 name: beta-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] xref: EC:3.2.1.53 xref: MetaCyc:3.2.1.53-RXN is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0032429 name: regulation of phospholipase A2 activity namespace: biological_process def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah] is_a: GO:0010517 ! regulation of phospholipase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004623 ! phospholipase A2 activity relationship: regulates GO:0004623 ! phospholipase A2 activity [Term] id: GO:0032430 name: positive regulation of phospholipase A2 activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah] synonym: "activation of phospholipase A2 activity" NARROW [] synonym: "stimulation of phospholipase A2 activity" NARROW [] synonym: "up regulation of phospholipase A2 activity" EXACT [] synonym: "up-regulation of phospholipase A2 activity" EXACT [] synonym: "upregulation of phospholipase A2 activity" EXACT [] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:0032429 ! regulation of phospholipase A2 activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004623 ! phospholipase A2 activity relationship: positively_regulates GO:0004623 ! phospholipase A2 activity [Term] id: GO:0032431 name: activation of phospholipase A2 activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah] synonym: "phospholipase A2 activation" EXACT [] is_a: GO:0032430 ! positive regulation of phospholipase A2 activity [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component alt_id: GO:0000141 alt_id: GO:0030482 def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005884 ! actin filament relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0032433 name: filopodium tip namespace: cellular_component def: "The end of a filopodium distal to the body of the cell." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0032434 name: regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032435 name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process is_a: GO:2000059 ! negative regulation of ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032436 name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process is_a: GO:2000060 ! positive regulation of ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032437 name: cuticular plate namespace: cellular_component def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0032438 name: melanosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] synonym: "melanosome organisation" EXACT [GOC:mah] synonym: "melanosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0032440 name: 2-alkenal reductase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74] synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74] xref: EC:1.3.1.74 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0032441 name: pheophorbide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336] xref: EC:1.14.15.17 xref: MetaCyc:RXN-7740 xref: RHEA:48140 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0032442 name: phenylcoumaran benzylic ether reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+." [PMID:11030549, PMID:13129921] synonym: "PCBER activity" EXACT [] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032443 name: regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0106118 ! regulation of sterol biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006696 ! ergosterol biosynthetic process relationship: regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0032444 name: activin responsive factor complex namespace: cellular_component def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). synonym: "ARF complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0032445 name: fructose import namespace: biological_process def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah] synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015755 ! fructose transmembrane transport [Term] id: GO:0032446 name: protein modification by small protein conjugation namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] is_a: GO:0070647 ! protein modification by small protein conjugation or removal [Term] id: GO:0032447 name: protein urmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0032448 name: DNA hairpin binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0032449 name: CBM complex namespace: cellular_component def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454] synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032450 name: maltose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] synonym: "maltase activity" EXACT [] xref: EC:3.2.1.20 xref: MetaCyc:RXN-2141 is_a: GO:0004558 ! alpha-1,4-glucosidase activity relationship: part_of GO:0000023 ! maltose metabolic process [Term] id: GO:0032451 name: demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] subset: goslim_pir is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0070988 ! demethylation [Term] id: GO:0032452 name: histone demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] xref: Reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3" xref: Reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3" xref: Reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3" xref: Reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3" xref: Reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3" xref: Reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3" xref: Reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3" xref: Reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4" xref: Reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters" xref: Reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters" xref: Reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters" xref: Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3" xref: Reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3" xref: Reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3" xref: Reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3" xref: Reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3" xref: Reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3" xref: Reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3" xref: Reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4" xref: Reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4" is_a: GO:0032451 ! demethylase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0016577 ! histone demethylation [Term] id: GO:0032453 name: histone demethylase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0034720 ! histone H3-K4 demethylation [Term] id: GO:0032454 name: histone demethylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein." [PMID:16362057] xref: Reactome:R-HSA-9011949 "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers" xref: Reactome:R-HSA-9011985 "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen" xref: Reactome:R-HSA-997263 "JMJD1C demethylates H3K9 mono- and di-methylation" is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0033169 ! histone H3-K9 demethylation [Term] id: GO:0032455 name: nerve growth factor processing namespace: biological_process def: "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor." [GOC:mah, PMID:8615794] synonym: "beta-nerve growth factor processing" EXACT [PR:000011194] synonym: "NGF processing" EXACT [PR:000011194] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0032456 name: endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "retrograde transport of endocytic vesicles" RELATED [] is_a: GO:0016197 ! endosomal transport [Term] id: GO:0032457 name: fast endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "direct endocytic recycling" EXACT [] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032458 name: slow endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032459 name: regulation of protein oligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051259 ! protein complex oligomerization relationship: regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032460 name: negative regulation of protein oligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah] synonym: "down regulation of protein oligomerization" EXACT [] synonym: "down-regulation of protein oligomerization" EXACT [] synonym: "downregulation of protein oligomerization" EXACT [] synonym: "inhibition of protein oligomerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0032459 ! regulation of protein oligomerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051259 ! protein complex oligomerization relationship: negatively_regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032461 name: positive regulation of protein oligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah] synonym: "activation of protein oligomerization" NARROW [] synonym: "induction of protein oligomerization" RELATED [] synonym: "stimulation of protein oligomerization" NARROW [] synonym: "up regulation of protein oligomerization" EXACT [] synonym: "up-regulation of protein oligomerization" EXACT [] synonym: "upregulation of protein oligomerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0032459 ! regulation of protein oligomerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051259 ! protein complex oligomerization relationship: positively_regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032462 name: regulation of protein homooligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah] is_a: GO:0032459 ! regulation of protein oligomerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051260 ! protein homooligomerization relationship: regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032463 name: negative regulation of protein homooligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah] synonym: "down regulation of protein homooligomerization" EXACT [] synonym: "down-regulation of protein homooligomerization" EXACT [] synonym: "downregulation of protein homooligomerization" EXACT [] synonym: "inhibition of protein homooligomerization" NARROW [] is_a: GO:0032460 ! negative regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051260 ! protein homooligomerization relationship: negatively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032464 name: positive regulation of protein homooligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah] synonym: "activation of protein homooligomerization" NARROW [] synonym: "induction of protein homooligomerization" RELATED [] synonym: "stimulation of protein homooligomerization" NARROW [] synonym: "up regulation of protein homooligomerization" EXACT [] synonym: "up-regulation of protein homooligomerization" EXACT [] synonym: "upregulation of protein homooligomerization" EXACT [] is_a: GO:0032461 ! positive regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051260 ! protein homooligomerization relationship: positively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032465 name: regulation of cytokinesis namespace: biological_process alt_id: GO:0071775 def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] synonym: "regulation of cell cycle cytokinesis" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000910 ! cytokinesis relationship: regulates GO:0000910 ! cytokinesis [Term] id: GO:0032466 name: negative regulation of cytokinesis namespace: biological_process alt_id: GO:0071776 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "down regulation of cytokinesis" EXACT [] synonym: "down-regulation of cytokinesis" EXACT [] synonym: "downregulation of cytokinesis" EXACT [] synonym: "inhibition of cytokinesis" NARROW [] synonym: "negative regulation of cell cycle cytokinesis" RELATED [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000910 ! cytokinesis relationship: negatively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032467 name: positive regulation of cytokinesis namespace: biological_process alt_id: GO:0071777 def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "activation of cytokinesis" NARROW [] synonym: "positive regulation of cell cycle cytokinesis" RELATED [] synonym: "stimulation of cytokinesis" NARROW [] synonym: "up regulation of cytokinesis" EXACT [] synonym: "up-regulation of cytokinesis" EXACT [] synonym: "upregulation of cytokinesis" EXACT [] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051781 ! positive regulation of cell division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000910 ! cytokinesis relationship: positively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032468 name: Golgi calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in Golgi" EXACT [] synonym: "Golgi calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in Golgi" EXACT [] synonym: "regulation of Golgi calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005794 ! Golgi apparatus relationship: occurs_in GO:0005794 ! Golgi apparatus [Term] id: GO:0032469 name: endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in ER" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion homeostasis" EXACT [] synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in ER" EXACT [] synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of ER calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum relationship: occurs_in GO:0005783 ! endoplasmic reticulum [Term] id: GO:0032470 name: positive regulation of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "elevation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "elevation of ER calcium ion concentration" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032471 name: negative regulation of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT [] synonym: "ER calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "reduction of calcium ion concentration in ER" EXACT [] synonym: "reduction of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "reduction of ER calcium ion concentration" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032472 name: Golgi calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] synonym: "Golgi calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0032473 name: cytoplasmic side of mitochondrial outer membrane namespace: cellular_component def: "The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] synonym: "external leaflet of mitochondrial outer membrane" EXACT [GOC:ab] synonym: "external side of mitochondrial envelope" RELATED [] synonym: "external side of mitochondrial outer membrane" EXACT [] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0032474 name: otolith morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0048840 ! otolith development [Term] id: GO:0032475 name: otolith formation namespace: biological_process def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0032474 ! otolith morphogenesis [Term] id: GO:0032476 name: decaprenyl diphosphate synthase complex namespace: cellular_component def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] subset: goslim_pir is_a: GO:1990234 ! transferase complex [Term] id: GO:0032477 name: homodimeric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032478 name: heterotetrameric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0032479 name: regulation of type I interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "regulation of type I IFN production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032606 ! type I interferon production relationship: regulates GO:0032606 ! type I interferon production [Term] id: GO:0032480 name: negative regulation of type I interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "down regulation of type I interferon production" EXACT [] synonym: "down-regulation of type I interferon production" EXACT [] synonym: "downregulation of type I interferon production" EXACT [] synonym: "inhibition of type I interferon production" NARROW [] synonym: "negative regulation of type I IFN production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032606 ! type I interferon production relationship: negatively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032481 name: positive regulation of type I interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "activation of type I interferon production" NARROW [] synonym: "positive regulation of type I IFN production" EXACT [] synonym: "stimulation of type I interferon production" NARROW [] synonym: "up regulation of type I interferon production" EXACT [] synonym: "up-regulation of type I interferon production" EXACT [] synonym: "upregulation of type I interferon production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032606 ! type I interferon production relationship: positively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032482 name: Rab protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032483 name: regulation of Rab protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032482 ! Rab protein signal transduction relationship: regulates GO:0032482 ! Rab protein signal transduction [Term] id: GO:0032484 name: Ral protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032485 name: regulation of Ral protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032484 ! Ral protein signal transduction relationship: regulates GO:0032484 ! Ral protein signal transduction [Term] id: GO:0032486 name: Rap protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032487 name: regulation of Rap protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032486 ! Rap protein signal transduction relationship: regulates GO:0032486 ! Rap protein signal transduction [Term] id: GO:0032488 name: Cdc42 protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah, PMID:18558478] synonym: "Cdc42 signaling" RELATED [GOC:vw] synonym: "Cdc42 signaling pathway" RELATED [GOC:vw] synonym: "cdc42 signalling pathway" RELATED [GOC:vw] is_a: GO:0007266 ! Rho protein signal transduction [Term] id: GO:0032489 name: regulation of Cdc42 protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah] is_a: GO:0035023 ! regulation of Rho protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032488 ! Cdc42 protein signal transduction relationship: regulates GO:0032488 ! Cdc42 protein signal transduction [Term] id: GO:0032490 name: detection of molecule of bacterial origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl] synonym: "detection of bacteria associated molecule" EXACT [] synonym: "detection of bacterial associated molecule" EXACT [] synonym: "detection of bacterium associated molecule" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032491 name: detection of molecule of fungal origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of fungal associated molecule" EXACT [] synonym: "detection of fungus associated molecule" EXACT [] is_a: GO:0002238 ! response to molecule of fungal origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032492 name: detection of molecule of oomycetes origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of oomycetes associated molecule" EXACT [] is_a: GO:0002240 ! response to molecule of oomycetes origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032493 name: response to bacterial lipoprotein namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0032494 name: response to peptidoglycan namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032495 name: response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] is_a: GO:0042493 ! response to drug is_a: GO:1901652 ! response to peptide [Term] id: GO:0032496 name: response to lipopolysaccharide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] synonym: "response to endotoxin" BROAD [GOC:sl] synonym: "response to LPS" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032497 name: detection of lipopolysaccharide namespace: biological_process def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797] synonym: "detection of LPS" EXACT [] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032496 ! response to lipopolysaccharide [Term] id: GO:0032498 name: detection of muramyl dipeptide namespace: biological_process def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797] is_a: GO:0032495 ! response to muramyl dipeptide is_a: GO:0032499 ! detection of peptidoglycan [Term] id: GO:0032499 name: detection of peptidoglycan namespace: biological_process def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032494 ! response to peptidoglycan [Term] id: GO:0032500 name: muramyl dipeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0044707 alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_aspergillus subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: janelomax creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032504 name: multicellular organism reproduction namespace: biological_process def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032505 name: reproduction of a single-celled organism namespace: biological_process def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] is_a: GO:0000003 ! reproduction [Term] id: GO:0032506 name: cytokinetic process namespace: biological_process def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000910 ! cytokinesis [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0032508 name: DNA duplex unwinding namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding" EXACT [] synonym: "duplex DNA melting" EXACT [] is_a: GO:0032392 ! DNA geometric change [Term] id: GO:0032509 name: endosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome transport via MVB sorting pathway" EXACT [] is_a: GO:0016197 ! endosomal transport is_a: GO:0071985 ! multivesicular body sorting pathway [Term] id: GO:0032510 name: endosome to lysosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT [] is_a: GO:0008333 ! endosome to lysosome transport is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway [Term] id: GO:0032511 name: late endosome to vacuole transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway is_a: GO:0045324 ! late endosome to vacuole transport [Term] id: GO:0032515 name: negative regulation of phosphoprotein phosphatase activity namespace: biological_process alt_id: GO:0032513 alt_id: GO:0034048 def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah] synonym: "down regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "down regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "down regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "down regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "down regulation of protein phosphatase type 2A activity" NARROW [] synonym: "down regulation of protein phosphatase type 2B activity" NARROW [] synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "down-regulation of protein phosphatase type 2A activity" NARROW [] synonym: "down-regulation of protein phosphatase type 2B activity" NARROW [] synonym: "downregulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "downregulation of phosphoprotein phosphatase activity" EXACT [] synonym: "downregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "downregulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "downregulation of protein phosphatase type 2A activity" NARROW [] synonym: "downregulation of protein phosphatase type 2B activity" NARROW [] synonym: "inhibition of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "inhibition of phosphoprotein phosphatase activity" NARROW [] synonym: "inhibition of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "inhibition of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "inhibition of protein phosphatase type 2A activity" NARROW [] synonym: "inhibition of protein phosphatase type 2B activity" NARROW [] synonym: "negative regulation of calcineurin activity" NARROW [] synonym: "negative regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "negative regulation of protein phosphatase type 2A activity" NARROW [] synonym: "negative regulation of protein phosphatase type 2B activity" NARROW [] synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:0035308 ! negative regulation of protein dephosphorylation is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity relationship: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0032516 name: positive regulation of phosphoprotein phosphatase activity namespace: biological_process alt_id: GO:0032514 alt_id: GO:0034049 def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah] synonym: "activation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "activation of phosphoprotein phosphatase activity" NARROW [] synonym: "activation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "activation of protein phosphatase type 2A activity" NARROW [] synonym: "activation of protein phosphatase type 2B activity" NARROW [] synonym: "calcineurin activation" NARROW [] synonym: "positive regulation of calcineurin activity" NARROW [] synonym: "positive regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "positive regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "positive regulation of protein phosphatase type 2A activity" NARROW [] synonym: "positive regulation of protein phosphatase type 2B activity" NARROW [] synonym: "stimulation of phosphoprotein phosphatase activity" NARROW [] synonym: "stimulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "stimulation of protein phosphatase type 2A activity" NARROW [] synonym: "stimulation of protein phosphatase type 2B activity" NARROW [] synonym: "up regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "up regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "up regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "up regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "up regulation of protein phosphatase type 2A activity" NARROW [] synonym: "up regulation of protein phosphatase type 2B activity" NARROW [] synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "up-regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "up-regulation of protein phosphatase type 2A activity" NARROW [] synonym: "up-regulation of protein phosphatase type 2B activity" NARROW [] synonym: "upregulation of phosphoprotein phosphatase activity" EXACT [] synonym: "upregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "upregulation of protein phosphatase type 2A activity" NARROW [] synonym: "upregulation of protein phosphatase type 2B activity" NARROW [] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0035307 ! positive regulation of protein dephosphorylation is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004721 ! phosphoprotein phosphatase activity relationship: positively_regulates GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0032517 name: SOD1-calcineurin complex namespace: cellular_component def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032523 name: silicon efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] synonym: "silicon efflux transporter activity" EXACT [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0032524 name: obsolete nutrient export namespace: biological_process def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. synonym: "nutrient export" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0032525 name: somite rostral/caudal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776] synonym: "somite rostrocaudal axis specification" EXACT [] synonym: "somite rostrocaudal polarity" RELATED [] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0032526 name: response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] synonym: "response to vitamin A acid" EXACT [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032527 name: protein exit from endoplasmic reticulum namespace: biological_process def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb] synonym: "protein exit from ER" EXACT [] synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein export from ER" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organisation" EXACT [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0032529 name: follicle cell microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] synonym: "follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organisation" EXACT [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032528 ! microvillus organization relationship: regulates GO:0032528 ! microvillus organization [Term] id: GO:0032531 name: regulation of follicle cell microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032529 ! follicle cell microvillus organization relationship: regulates GO:0032529 ! follicle cell microvillus organization [Term] id: GO:0032532 name: regulation of microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus." [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0032536 ! regulation of cell projection size [Term] id: GO:0032533 name: regulation of follicle cell microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500] is_a: GO:0008361 ! regulation of cell size is_a: GO:0032531 ! regulation of follicle cell microvillus organization is_a: GO:0032532 ! regulation of microvillus length [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030033 ! microvillus assembly relationship: regulates GO:0030033 ! microvillus assembly [Term] id: GO:0032535 name: regulation of cellular component size namespace: biological_process def: "A process that modulates the size of a cellular component." [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0032536 name: regulation of cell projection size namespace: biological_process def: "A process that modulates the size of a cell projection." [GOC:mah] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0032537 name: host-seeking behavior namespace: biological_process def: "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, GOC:pr, PMID:11931033] synonym: "host-seeking behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0032538 name: regulation of host-seeking behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "regulation of host-seeking behaviour" EXACT [] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032537 ! host-seeking behavior relationship: regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032539 name: negative regulation of host-seeking behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "down regulation of host-seeking behavior" EXACT [] synonym: "down-regulation of host-seeking behavior" EXACT [] synonym: "downregulation of host-seeking behavior" EXACT [] synonym: "inhibition of host-seeking behavior" NARROW [] synonym: "negative regulation of host-seeking behaviour" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048521 ! negative regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032537 ! host-seeking behavior relationship: negatively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032540 name: positive regulation of host-seeking behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "activation of host-seeking behavior" NARROW [] synonym: "positive regulation of host-seeking behaviour" EXACT [] synonym: "stimulation of host-seeking behavior" NARROW [] synonym: "up regulation of host-seeking behavior" EXACT [] synonym: "up-regulation of host-seeking behavior" EXACT [] synonym: "upregulation of host-seeking behavior" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048520 ! positive regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032537 ! host-seeking behavior relationship: positively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032541 name: cortical endoplasmic reticulum namespace: cellular_component def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] comment: The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860) synonym: "cortical ER" EXACT [] synonym: "ER-PM peripheral junction" BROAD [GOC:ans, PMID:21062895] synonym: "peripheral endoplasmic reticulum" RELATED [] synonym: "peripheral ER" RELATED [] is_a: GO:0071782 ! endoplasmic reticulum tubular network intersection_of: GO:0071782 ! endoplasmic reticulum tubular network intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0032542 name: sulfiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] synonym: "Srx1" RELATED [EC:1.8.98.2] synonym: "sulphiredoxin activity" EXACT [] xref: EC:1.8.98.2 xref: MetaCyc:1.8.98.2-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] subset: goslim_drosophila subset: goslim_yeast synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0005739 ! mitochondrion intersection_of: part_of GO:0140053 ! mitochondrial gene expression relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0140053 ! mitochondrial gene expression [Term] id: GO:0032544 name: plastid translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "plastid protein anabolism" EXACT [] synonym: "plastid protein biosynthesis" EXACT [] synonym: "plastid protein formation" EXACT [] synonym: "plastid protein synthesis" EXACT [] synonym: "plastid protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0009657 ! plastid organization intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0009536 ! plastid relationship: occurs_in GO:0009536 ! plastid [Term] id: GO:0032545 name: CURI complex namespace: cellular_component def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p." [PMID:17452446] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032546 name: deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032547 name: purine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032548 name: pyrimidine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032549 name: ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032550 name: purine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032551 name: pyrimidine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032552 name: deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032553 name: ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032554 name: purine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032555 name: purine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032556 name: pyrimidine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032557 name: pyrimidine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032558 name: adenyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding [Term] id: GO:0032559 name: adenyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032560 name: guanyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032561 name: guanyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032562 name: dAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dAMP, deoxyadenosine monophosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032563 name: dADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dADP, deoxyadenosine diphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032564 name: dATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032565 name: dGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGMP, deoxyguanosine monophosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032566 name: dGDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGDP, deoxyguanosine diphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032567 name: dGTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032570 name: response to progesterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] synonym: "response to progesterone stimulus" EXACT [GOC:dos] is_a: GO:0042493 ! response to drug is_a: GO:0048545 ! response to steroid hormone is_a: GO:1901654 ! response to ketone [Term] id: GO:0032571 name: response to vitamin K namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0032572 name: response to menaquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl] synonym: "response to menatetrenone" EXACT [] synonym: "response to vitamin K2" EXACT [] is_a: GO:1901654 ! response to ketone [Term] id: GO:0032573 name: response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] synonym: "response to vitamin K1" EXACT [] is_a: GO:0033273 ! response to vitamin is_a: GO:1901654 ! response to ketone [Term] id: GO:0032574 name: 5'-3' RNA helicase activity namespace: molecular_function alt_id: GO:0032575 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "5' to 3' RNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' RNA helicase activity" EXACT [] is_a: GO:0003724 ! RNA helicase activity [Term] id: GO:0032576 name: O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032577 name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] is_a: GO:0032576 ! O-linoleoyltransferase activity [Term] id: GO:0032578 name: aleurone grain membrane namespace: cellular_component def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0033095 ! aleurone grain [Term] id: GO:0032579 name: apical lamina of hyaline layer namespace: cellular_component def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0033166 ! hyaline layer [Term] id: GO:0032580 name: Golgi cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] synonym: "Golgi stack membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0031985 ! Golgi cisterna [Term] id: GO:0032581 name: ER-dependent peroxisome organization namespace: biological_process def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399] synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah] synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah] synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah] is_a: GO:0007031 ! peroxisome organization [Term] id: GO:0032584 name: growth cone membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0030426 ! growth cone [Term] id: GO:0032585 name: multivesicular body membrane namespace: cellular_component def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] synonym: "multivesicular endosome membrane" EXACT [] synonym: "MVB membrane" EXACT [] synonym: "MVE membrane" EXACT [] is_a: GO:0031902 ! late endosome membrane relationship: part_of GO:0005771 ! multivesicular body [Term] id: GO:0032586 name: protein storage vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] is_a: GO:0009705 ! plant-type vacuole membrane [Term] id: GO:0032587 name: ruffle membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] synonym: "membrane ruffle" RELATED [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0001726 ! ruffle [Term] id: GO:0032588 name: trans-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] synonym: "Golgi trans face membrane" RELATED [] synonym: "trans Golgi network membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0005802 ! trans-Golgi network [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0032590 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane [Term] id: GO:0032591 name: dendritic spine membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane is_a: GO:0097060 ! synaptic membrane relationship: part_of GO:0032590 ! dendrite membrane [Term] id: GO:0032592 name: integral component of mitochondrial membrane namespace: cellular_component def: "The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098573 ! intrinsic component of mitochondrial membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0031966 ! mitochondrial membrane [Term] id: GO:0032593 name: insulin-responsive compartment namespace: cellular_component def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] synonym: "GLUT4 storage compartment" EXACT [] synonym: "GSC" RELATED [] synonym: "IRC" RELATED [] is_a: GO:0030141 ! secretory granule [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051668 ! localization within membrane is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: occurs_in GO:0016020 ! membrane [Term] id: GO:0032595 name: B cell receptor transport within lipid bilayer namespace: biological_process def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah] synonym: "B cell receptor translocation within membrane" EXACT [] synonym: "BCR translocation within membrane" EXACT [] synonym: "BCR transport within lipid bilayer" EXACT [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032596 name: protein transport into membrane raft namespace: biological_process def: "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "protein translocation into membrane raft" EXACT [] synonym: "protein transport into lipid raft" EXACT [] synonym: "receptor translocation into membrane raft" NARROW [] synonym: "receptor transport into membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:1903044 ! protein localization to membrane raft [Term] id: GO:0032597 name: B cell receptor transport into membrane raft namespace: biological_process def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah] synonym: "B cell receptor translocation into membrane raft" EXACT [] synonym: "B cell receptor transport into lipid raft" EXACT [] synonym: "BCR translocation into membrane raft" EXACT [] synonym: "BCR transport into membrane raft" EXACT [] is_a: GO:0032595 ! B cell receptor transport within lipid bilayer is_a: GO:0032596 ! protein transport into membrane raft [Term] id: GO:0032598 name: B cell receptor transport into immunological synapse namespace: biological_process def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah] synonym: "B cell receptor translocation into immunological synapse" EXACT [] synonym: "BCR translocation into immunological synapse" EXACT [] synonym: "BCR transport into immunological synapse" EXACT [] is_a: GO:0032597 ! B cell receptor transport into membrane raft [Term] id: GO:0032599 name: protein transport out of membrane raft namespace: biological_process def: "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "protein translocation out of membrane raft" EXACT [] synonym: "protein transport out of lipid raft" EXACT [] synonym: "receptor translocation out of membrane raft" NARROW [] synonym: "receptor transport out of membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032600 name: chemokine receptor transport out of membrane raft namespace: biological_process def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah] synonym: "chemokine receptor translocation out of membrane raft" EXACT [] synonym: "chemokine receptor transport out of lipid raft" EXACT [] is_a: GO:0032599 ! protein transport out of membrane raft is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer [Term] id: GO:0032601 name: connective tissue growth factor production namespace: biological_process def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "CCN2 production" EXACT [] synonym: "CTGF production" EXACT [] synonym: "Fisp12 production" EXACT [] synonym: "Hcs24 production" EXACT [] synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "IGFBP8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032602 name: chemokine production namespace: biological_process def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032603 name: fractalkine production namespace: biological_process def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0032604 name: granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "GM-CSF production" EXACT [GOC:vk] synonym: "granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032605 name: hepatocyte growth factor production namespace: biological_process def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032606 name: type I interferon production namespace: biological_process def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032607 name: interferon-alpha production namespace: biological_process def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-alpha production" EXACT [GOC:mah] synonym: "IFNA production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032608 name: interferon-beta production namespace: biological_process def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-beta production" EXACT [] synonym: "IFNB production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032609 name: interferon-gamma production namespace: biological_process def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "IFNG production" EXACT [GOC:mah] synonym: "type II IFN production" BROAD [GOC:mah] synonym: "type II interferon production" BROAD [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032610 name: interleukin-1 alpha production namespace: biological_process def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 alpha production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032611 name: interleukin-1 beta production namespace: biological_process def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 beta production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production namespace: biological_process def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production namespace: biological_process def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-10 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032614 name: interleukin-11 production namespace: biological_process def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-11 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032615 name: interleukin-12 production namespace: biological_process def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-12 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production namespace: biological_process def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-13 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032617 name: interleukin-14 production namespace: biological_process def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-14 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032618 name: interleukin-15 production namespace: biological_process def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-15 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032619 name: interleukin-16 production namespace: biological_process def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-16 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production namespace: biological_process def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, PR:000001092, Wikipedia:Interleukin_17] synonym: "IL-17 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032621 name: interleukin-18 production namespace: biological_process def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-18 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032622 name: interleukin-19 production namespace: biological_process def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-19 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production namespace: biological_process def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-2 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032624 name: interleukin-20 production namespace: biological_process def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-20 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032625 name: interleukin-21 production namespace: biological_process def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-21 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production namespace: biological_process def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-22 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032627 name: interleukin-23 production namespace: biological_process def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-23 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032628 name: interleukin-24 production namespace: biological_process def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-24 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032629 name: interleukin-25 production namespace: biological_process def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-25 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032630 name: interleukin-26 production namespace: biological_process def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-26 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032631 name: interleukin-27 production namespace: biological_process def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-27 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032632 name: interleukin-3 production namespace: biological_process def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-3 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production namespace: biological_process def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-4 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032634 name: interleukin-5 production namespace: biological_process def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-5 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production namespace: biological_process def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-6 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032636 name: interleukin-7 production namespace: biological_process def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-7 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production namespace: biological_process def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production namespace: biological_process def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-9 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032639 name: TRAIL production namespace: biological_process def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032640 name: tumor necrosis factor production namespace: biological_process def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "TNF production" EXACT [] synonym: "TNF-alpha production" EXACT [] synonym: "tumor necrosis factor-alpha production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032641 name: lymphotoxin A production namespace: biological_process def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "LTA production" EXACT [] synonym: "lymphotoxin-alpha production" EXACT [] synonym: "TNF-beta production" EXACT [] synonym: "tumor necrosis factor-beta production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032642 name: regulation of chemokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032602 ! chemokine production relationship: regulates GO:0032602 ! chemokine production [Term] id: GO:0032643 name: regulation of connective tissue growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "regulation of CCN2 production" EXACT [] synonym: "regulation of CTGF production" EXACT [] synonym: "regulation of Fisp12 production" EXACT [] synonym: "regulation of Hcs24 production" EXACT [] synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "regulation of IGFBP8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032601 ! connective tissue growth factor production relationship: regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032644 name: regulation of fractalkine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032603 ! fractalkine production relationship: regulates GO:0032603 ! fractalkine production [Term] id: GO:0032645 name: regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "regulation of GM-CSF production" EXACT [GOC:vk] synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032646 name: regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032605 ! hepatocyte growth factor production relationship: regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032647 name: regulation of interferon-alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah] is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032607 ! interferon-alpha production relationship: regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032648 name: regulation of interferon-beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "regulation of IFN-beta production" EXACT [] is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032608 ! interferon-beta production relationship: regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032649 name: regulation of interferon-gamma production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "regulation of type II interferon production" BROAD [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032609 ! interferon-gamma production relationship: regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032650 name: regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "regulation of IL-1 alpha production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032610 ! interleukin-1 alpha production relationship: regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032651 name: regulation of interleukin-1 beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "regulation of IL-1 beta production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032611 ! interleukin-1 beta production relationship: regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032652 name: regulation of interleukin-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "regulation of IL-1 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032612 ! interleukin-1 production relationship: regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032653 name: regulation of interleukin-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "regulation of IL-10 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032613 ! interleukin-10 production relationship: regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032654 name: regulation of interleukin-11 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "regulation of IL-11 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032614 ! interleukin-11 production relationship: regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032655 name: regulation of interleukin-12 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "regulation of IL-12 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032615 ! interleukin-12 production relationship: regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032656 name: regulation of interleukin-13 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "regulation of IL-13 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032616 ! interleukin-13 production relationship: regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032657 name: regulation of interleukin-14 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "regulation of IL-14 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032617 ! interleukin-14 production relationship: regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032658 name: regulation of interleukin-15 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "regulation of IL-15 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032618 ! interleukin-15 production relationship: regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032659 name: regulation of interleukin-16 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "regulation of IL-16 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032619 ! interleukin-16 production relationship: regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032660 name: regulation of interleukin-17 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "regulation of IL-17 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032620 ! interleukin-17 production relationship: regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032661 name: regulation of interleukin-18 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "regulation of IL-18 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032621 ! interleukin-18 production relationship: regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032662 name: regulation of interleukin-19 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "regulation of IL-19 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032622 ! interleukin-19 production relationship: regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032663 name: regulation of interleukin-2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "regulation of IL-2 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032623 ! interleukin-2 production relationship: regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032664 name: regulation of interleukin-20 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "regulation of IL-20 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032624 ! interleukin-20 production relationship: regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032665 name: regulation of interleukin-21 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "regulation of IL-21 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032625 ! interleukin-21 production relationship: regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032666 name: regulation of interleukin-22 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "regulation of IL-22 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032626 ! interleukin-22 production relationship: regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032667 name: regulation of interleukin-23 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "regulation of IL-23 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032627 ! interleukin-23 production relationship: regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032668 name: regulation of interleukin-24 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "regulation of IL-24 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032628 ! interleukin-24 production relationship: regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032669 name: regulation of interleukin-25 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "regulation of IL-25 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032629 ! interleukin-25 production relationship: regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032670 name: regulation of interleukin-26 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "regulation of IL-26 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032630 ! interleukin-26 production relationship: regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032671 name: regulation of interleukin-27 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "regulation of IL-27 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032631 ! interleukin-27 production relationship: regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032672 name: regulation of interleukin-3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "regulation of IL-3 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032632 ! interleukin-3 production relationship: regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032673 name: regulation of interleukin-4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "regulation of IL-4 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032633 ! interleukin-4 production relationship: regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032674 name: regulation of interleukin-5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "regulation of IL-5 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032634 ! interleukin-5 production relationship: regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032675 name: regulation of interleukin-6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "regulation of IL-6 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032635 ! interleukin-6 production relationship: regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032676 name: regulation of interleukin-7 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "regulation of IL-7 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032636 ! interleukin-7 production relationship: regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032677 name: regulation of interleukin-8 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "regulation of IL-8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032637 ! interleukin-8 production relationship: regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032678 name: regulation of interleukin-9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "regulation of IL-9 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032638 ! interleukin-9 production relationship: regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032679 name: regulation of TRAIL production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032639 ! TRAIL production relationship: regulates GO:0032639 ! TRAIL production [Term] id: GO:0032680 name: regulation of tumor necrosis factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of TNF production" EXACT [] synonym: "regulation of TNF-alpha production" EXACT [] synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032640 ! tumor necrosis factor production relationship: regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032681 name: regulation of lymphotoxin A production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "regulation of LTA production" EXACT [] synonym: "regulation of lymphotoxin-alpha production" EXACT [] synonym: "regulation of TNF-beta production" EXACT [] synonym: "regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032641 ! lymphotoxin A production relationship: regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032682 name: negative regulation of chemokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "down regulation of chemokine production" EXACT [] synonym: "down-regulation of chemokine production" EXACT [] synonym: "downregulation of chemokine production" EXACT [] synonym: "inhibition of chemokine production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032602 ! chemokine production relationship: negatively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032683 name: negative regulation of connective tissue growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "down regulation of connective tissue growth factor production" EXACT [] synonym: "down-regulation of connective tissue growth factor production" EXACT [] synonym: "downregulation of connective tissue growth factor production" EXACT [] synonym: "inhibition of connective tissue growth factor production" NARROW [] synonym: "negative regulation of CCN2 production" EXACT [] synonym: "negative regulation of CTGF production" EXACT [] synonym: "negative regulation of Fisp12 production" EXACT [] synonym: "negative regulation of Hcs24 production" EXACT [] synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "negative regulation of IGFBP8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032601 ! connective tissue growth factor production relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032684 name: negative regulation of fractalkine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "down regulation of fractalkine production" EXACT [] synonym: "down-regulation of fractalkine production" EXACT [] synonym: "downregulation of fractalkine production" EXACT [] synonym: "inhibition of fractalkine production" NARROW [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032682 ! negative regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032603 ! fractalkine production relationship: negatively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032685 name: negative regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "negative regulation of GM-CSF production" EXACT [GOC:vk] synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032686 name: negative regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "down regulation of hepatocyte growth factor production" EXACT [] synonym: "down-regulation of hepatocyte growth factor production" EXACT [] synonym: "downregulation of hepatocyte growth factor production" EXACT [] synonym: "inhibition of hepatocyte growth factor production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032605 ! hepatocyte growth factor production relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032687 name: negative regulation of interferon-alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "down regulation of interferon-alpha production" EXACT [] synonym: "down-regulation of interferon-alpha production" EXACT [] synonym: "downregulation of interferon-alpha production" EXACT [] synonym: "inhibition of interferon-alpha production" NARROW [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032607 ! interferon-alpha production relationship: negatively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032688 name: negative regulation of interferon-beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "down regulation of interferon-beta production" EXACT [] synonym: "down-regulation of interferon-beta production" EXACT [] synonym: "downregulation of interferon-beta production" EXACT [] synonym: "inhibition of interferon-beta production" NARROW [] synonym: "negative regulation of IFN-beta production" EXACT [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032608 ! interferon-beta production relationship: negatively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032689 name: negative regulation of interferon-gamma production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "down regulation of interferon-gamma production" EXACT [] synonym: "down-regulation of interferon-gamma production" EXACT [] synonym: "downregulation of interferon-gamma production" EXACT [] synonym: "inhibition of interferon-gamma production" NARROW [] synonym: "negative regulation of type II interferon production" BROAD [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032609 ! interferon-gamma production relationship: negatively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032690 name: negative regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "down regulation of interleukin-1 alpha production" EXACT [] synonym: "down-regulation of interleukin-1 alpha production" EXACT [] synonym: "downregulation of interleukin-1 alpha production" EXACT [] synonym: "inhibition of interleukin-1 alpha production" NARROW [] synonym: "negative regulation of IL-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032692 ! negative regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032610 ! interleukin-1 alpha production relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032691 name: negative regulation of interleukin-1 beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "down regulation of interleukin-1 beta production" EXACT [] synonym: "down-regulation of interleukin-1 beta production" EXACT [] synonym: "downregulation of interleukin-1 beta production" EXACT [] synonym: "inhibition of interleukin-1 beta production" NARROW [] synonym: "negative regulation of IL-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032692 ! negative regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032611 ! interleukin-1 beta production relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032692 name: negative regulation of interleukin-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "down regulation of interleukin-1 production" EXACT [] synonym: "down-regulation of interleukin-1 production" EXACT [] synonym: "downregulation of interleukin-1 production" EXACT [] synonym: "inhibition of interleukin-1 production" NARROW [] synonym: "negative regulation of IL-1 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032612 ! interleukin-1 production relationship: negatively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032693 name: negative regulation of interleukin-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "down regulation of interleukin-10 production" EXACT [] synonym: "down-regulation of interleukin-10 production" EXACT [] synonym: "downregulation of interleukin-10 production" EXACT [] synonym: "inhibition of interleukin-10 production" NARROW [] synonym: "negative regulation of IL-10 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032613 ! interleukin-10 production relationship: negatively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032694 name: negative regulation of interleukin-11 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "down regulation of interleukin-11 production" EXACT [] synonym: "down-regulation of interleukin-11 production" EXACT [] synonym: "downregulation of interleukin-11 production" EXACT [] synonym: "inhibition of interleukin-11 production" NARROW [] synonym: "negative regulation of IL-11 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032614 ! interleukin-11 production relationship: negatively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032695 name: negative regulation of interleukin-12 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "down regulation of interleukin-12 production" EXACT [] synonym: "down-regulation of interleukin-12 production" EXACT [] synonym: "downregulation of interleukin-12 production" EXACT [] synonym: "inhibition of interleukin-12 production" NARROW [] synonym: "negative regulation of IL-12 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032615 ! interleukin-12 production relationship: negatively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032696 name: negative regulation of interleukin-13 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "down regulation of interleukin-13 production" EXACT [] synonym: "down-regulation of interleukin-13 production" EXACT [] synonym: "downregulation of interleukin-13 production" EXACT [] synonym: "inhibition of interleukin-13 production" NARROW [] synonym: "negative regulation of IL-13 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032616 ! interleukin-13 production relationship: negatively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032697 name: negative regulation of interleukin-14 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "down regulation of interleukin-14 production" EXACT [] synonym: "down-regulation of interleukin-14 production" EXACT [] synonym: "downregulation of interleukin-14 production" EXACT [] synonym: "inhibition of interleukin-14 production" NARROW [] synonym: "negative regulation of IL-14 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032617 ! interleukin-14 production relationship: negatively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032698 name: negative regulation of interleukin-15 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "down regulation of interleukin-15 production" EXACT [] synonym: "down-regulation of interleukin-15 production" EXACT [] synonym: "downregulation of interleukin-15 production" EXACT [] synonym: "inhibition of interleukin-15 production" NARROW [] synonym: "negative regulation of IL-15 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032618 ! interleukin-15 production relationship: negatively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032699 name: negative regulation of interleukin-16 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "down regulation of interleukin-16 production" EXACT [] synonym: "down-regulation of interleukin-16 production" EXACT [] synonym: "downregulation of interleukin-16 production" EXACT [] synonym: "inhibition of interleukin-16 production" NARROW [] synonym: "negative regulation of IL-16 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032619 ! interleukin-16 production relationship: negatively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032700 name: negative regulation of interleukin-17 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "down regulation of interleukin-17 production" EXACT [] synonym: "down-regulation of interleukin-17 production" EXACT [] synonym: "downregulation of interleukin-17 production" EXACT [] synonym: "inhibition of interleukin-17 production" NARROW [] synonym: "negative regulation of IL-17 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032620 ! interleukin-17 production relationship: negatively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032701 name: negative regulation of interleukin-18 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "down regulation of interleukin-18 production" EXACT [] synonym: "down-regulation of interleukin-18 production" EXACT [] synonym: "downregulation of interleukin-18 production" EXACT [] synonym: "inhibition of interleukin-18 production" NARROW [] synonym: "negative regulation of IL-18 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032621 ! interleukin-18 production relationship: negatively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032702 name: negative regulation of interleukin-19 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "down regulation of interleukin-19 production" EXACT [] synonym: "down-regulation of interleukin-19 production" EXACT [] synonym: "downregulation of interleukin-19 production" EXACT [] synonym: "inhibition of interleukin-19 production" NARROW [] synonym: "negative regulation of IL-19 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032622 ! interleukin-19 production relationship: negatively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032703 name: negative regulation of interleukin-2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "down regulation of interleukin-2 production" EXACT [] synonym: "down-regulation of interleukin-2 production" EXACT [] synonym: "downregulation of interleukin-2 production" EXACT [] synonym: "inhibition of interleukin-2 production" NARROW [] synonym: "negative regulation of IL-2 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032623 ! interleukin-2 production relationship: negatively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032704 name: negative regulation of interleukin-20 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "down regulation of interleukin-20 production" EXACT [] synonym: "down-regulation of interleukin-20 production" EXACT [] synonym: "downregulation of interleukin-20 production" EXACT [] synonym: "inhibition of interleukin-20 production" NARROW [] synonym: "negative regulation of IL-20 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032624 ! interleukin-20 production relationship: negatively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032705 name: negative regulation of interleukin-21 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "down regulation of interleukin-21 production" EXACT [] synonym: "down-regulation of interleukin-21 production" EXACT [] synonym: "downregulation of interleukin-21 production" EXACT [] synonym: "inhibition of interleukin-21 production" NARROW [] synonym: "negative regulation of IL-21 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032625 ! interleukin-21 production relationship: negatively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032706 name: negative regulation of interleukin-22 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "down regulation of interleukin-22 production" EXACT [] synonym: "down-regulation of interleukin-22 production" EXACT [] synonym: "downregulation of interleukin-22 production" EXACT [] synonym: "inhibition of interleukin-22 production" NARROW [] synonym: "negative regulation of IL-22 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032626 ! interleukin-22 production relationship: negatively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032707 name: negative regulation of interleukin-23 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "down regulation of interleukin-23 production" EXACT [] synonym: "down-regulation of interleukin-23 production" EXACT [] synonym: "downregulation of interleukin-23 production" EXACT [] synonym: "inhibition of interleukin-23 production" NARROW [] synonym: "negative regulation of IL-23 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032627 ! interleukin-23 production relationship: negatively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032708 name: negative regulation of interleukin-24 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "down regulation of interleukin-24 production" EXACT [] synonym: "down-regulation of interleukin-24 production" EXACT [] synonym: "downregulation of interleukin-24 production" EXACT [] synonym: "inhibition of interleukin-24 production" NARROW [] synonym: "negative regulation of IL-24 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032628 ! interleukin-24 production relationship: negatively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032709 name: negative regulation of interleukin-25 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "down regulation of interleukin-25 production" EXACT [] synonym: "down-regulation of interleukin-25 production" EXACT [] synonym: "downregulation of interleukin-25 production" EXACT [] synonym: "inhibition of interleukin-25 production" NARROW [] synonym: "negative regulation of IL-25 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032629 ! interleukin-25 production relationship: negatively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032710 name: negative regulation of interleukin-26 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "down regulation of interleukin-26 production" EXACT [] synonym: "down-regulation of interleukin-26 production" EXACT [] synonym: "downregulation of interleukin-26 production" EXACT [] synonym: "inhibition of interleukin-26 production" NARROW [] synonym: "negative regulation of IL-26 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032630 ! interleukin-26 production relationship: negatively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032711 name: negative regulation of interleukin-27 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "down regulation of interleukin-27 production" EXACT [] synonym: "down-regulation of interleukin-27 production" EXACT [] synonym: "downregulation of interleukin-27 production" EXACT [] synonym: "inhibition of interleukin-27 production" NARROW [] synonym: "negative regulation of IL-27 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032631 ! interleukin-27 production relationship: negatively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032712 name: negative regulation of interleukin-3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "down regulation of interleukin-3 production" EXACT [] synonym: "down-regulation of interleukin-3 production" EXACT [] synonym: "downregulation of interleukin-3 production" EXACT [] synonym: "inhibition of interleukin-3 production" NARROW [] synonym: "negative regulation of IL-3 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032632 ! interleukin-3 production relationship: negatively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032713 name: negative regulation of interleukin-4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "down regulation of interleukin-4 production" EXACT [] synonym: "down-regulation of interleukin-4 production" EXACT [] synonym: "downregulation of interleukin-4 production" EXACT [] synonym: "inhibition of interleukin-4 production" NARROW [] synonym: "negative regulation of IL-4 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032633 ! interleukin-4 production relationship: negatively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032714 name: negative regulation of interleukin-5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "down regulation of interleukin-5 production" EXACT [] synonym: "down-regulation of interleukin-5 production" EXACT [] synonym: "downregulation of interleukin-5 production" EXACT [] synonym: "inhibition of interleukin-5 production" NARROW [] synonym: "negative regulation of IL-5 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032634 ! interleukin-5 production relationship: negatively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032715 name: negative regulation of interleukin-6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "down regulation of interleukin-6 production" EXACT [] synonym: "down-regulation of interleukin-6 production" EXACT [] synonym: "downregulation of interleukin-6 production" EXACT [] synonym: "inhibition of interleukin-6 production" NARROW [] synonym: "negative regulation of IL-6 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032635 ! interleukin-6 production relationship: negatively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032716 name: negative regulation of interleukin-7 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "down regulation of interleukin-7 production" EXACT [] synonym: "down-regulation of interleukin-7 production" EXACT [] synonym: "downregulation of interleukin-7 production" EXACT [] synonym: "inhibition of interleukin-7 production" NARROW [] synonym: "negative regulation of IL-7 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032636 ! interleukin-7 production relationship: negatively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032717 name: negative regulation of interleukin-8 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "down regulation of interleukin-8 production" EXACT [] synonym: "down-regulation of interleukin-8 production" EXACT [] synonym: "downregulation of interleukin-8 production" EXACT [] synonym: "inhibition of interleukin-8 production" NARROW [] synonym: "negative regulation of IL-8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032637 ! interleukin-8 production relationship: negatively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032718 name: negative regulation of interleukin-9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "down regulation of interleukin-9 production" EXACT [] synonym: "down-regulation of interleukin-9 production" EXACT [] synonym: "downregulation of interleukin-9 production" EXACT [] synonym: "inhibition of interleukin-9 production" NARROW [] synonym: "negative regulation of IL-9 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032638 ! interleukin-9 production relationship: negatively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032719 name: negative regulation of TRAIL production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "down regulation of TRAIL production" EXACT [] synonym: "down-regulation of TRAIL production" EXACT [] synonym: "downregulation of TRAIL production" EXACT [] synonym: "inhibition of TRAIL production" NARROW [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032639 ! TRAIL production relationship: negatively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032720 name: negative regulation of tumor necrosis factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor production" EXACT [] synonym: "down-regulation of tumor necrosis factor production" EXACT [] synonym: "downregulation of tumor necrosis factor production" EXACT [] synonym: "inhibition of tumor necrosis factor production" NARROW [] synonym: "negative regulation TNF production" EXACT [] synonym: "negative regulation TNF-alpha production" EXACT [] synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032640 ! tumor necrosis factor production relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032721 name: negative regulation of lymphotoxin A production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "down regulation of lymphotoxin A production" EXACT [] synonym: "down-regulation of lymphotoxin A production" EXACT [] synonym: "downregulation of lymphotoxin A production" EXACT [] synonym: "inhibition of lymphotoxin A production" NARROW [] synonym: "negative regulation of LTA production" EXACT [] synonym: "negative regulation of lymphotoxin-alpha production" EXACT [] synonym: "negative regulation of TNF-beta production" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032641 ! lymphotoxin A production relationship: negatively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032722 name: positive regulation of chemokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "activation of chemokine production" NARROW [] synonym: "stimulation of chemokine production" NARROW [] synonym: "up regulation of chemokine production" EXACT [] synonym: "up-regulation of chemokine production" EXACT [] synonym: "upregulation of chemokine production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032602 ! chemokine production relationship: positively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032723 name: positive regulation of connective tissue growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "activation of connective tissue growth factor production" NARROW [] synonym: "positive regulation of CCN2 production" EXACT [] synonym: "positive regulation of CTGF production" EXACT [] synonym: "positive regulation of Fisp12 production" EXACT [] synonym: "positive regulation of Hcs24 production" EXACT [] synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "positive regulation of IGFBP8 production" EXACT [] synonym: "stimulation of connective tissue growth factor production" NARROW [] synonym: "up regulation of connective tissue growth factor production" EXACT [] synonym: "up-regulation of connective tissue growth factor production" EXACT [] synonym: "upregulation of connective tissue growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032601 ! connective tissue growth factor production relationship: positively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032724 name: positive regulation of fractalkine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "activation of fractalkine production" NARROW [] synonym: "stimulation of fractalkine production" NARROW [] synonym: "up regulation of fractalkine production" EXACT [] synonym: "up-regulation of fractalkine production" EXACT [] synonym: "upregulation of fractalkine production" EXACT [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032722 ! positive regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032603 ! fractalkine production relationship: positively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032725 name: positive regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "positive regulation of GM-CSF production" EXACT [GOC:vk] synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT [] synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032726 name: positive regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "activation of hepatocyte growth factor production" NARROW [] synonym: "stimulation of hepatocyte growth factor production" NARROW [] synonym: "up regulation of hepatocyte growth factor production" EXACT [] synonym: "up-regulation of hepatocyte growth factor production" EXACT [] synonym: "upregulation of hepatocyte growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032605 ! hepatocyte growth factor production relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032727 name: positive regulation of interferon-alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "activation of interferon-alpha production" NARROW [] synonym: "stimulation of interferon-alpha production" NARROW [] synonym: "up regulation of interferon-alpha production" EXACT [] synonym: "up-regulation of interferon-alpha production" EXACT [] synonym: "upregulation of interferon-alpha production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032607 ! interferon-alpha production relationship: positively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032728 name: positive regulation of interferon-beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "activation of interferon-beta production" NARROW [] synonym: "positive regulation of IFN-beta production" EXACT [] synonym: "stimulation of interferon-beta production" NARROW [] synonym: "up regulation of interferon-beta production" EXACT [] synonym: "up-regulation of interferon-beta production" EXACT [] synonym: "upregulation of interferon-beta production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032608 ! interferon-beta production relationship: positively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032729 name: positive regulation of interferon-gamma production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "activation of interferon-gamma production" NARROW [] synonym: "positive regulation of type II interferon production" BROAD [] synonym: "stimulation of interferon-gamma production" NARROW [] synonym: "up regulation of interferon-gamma production" EXACT [] synonym: "up-regulation of interferon-gamma production" EXACT [] synonym: "upregulation of interferon-gamma production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032609 ! interferon-gamma production relationship: positively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032730 name: positive regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "activation of interleukin-1 alpha production" NARROW [] synonym: "positive regulation of IL-1 alpha production" EXACT [] synonym: "stimulation of interleukin-1 alpha production" NARROW [] synonym: "up regulation of interleukin-1 alpha production" EXACT [] synonym: "up-regulation of interleukin-1 alpha production" EXACT [] synonym: "upregulation of interleukin-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032732 ! positive regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032610 ! interleukin-1 alpha production relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032731 name: positive regulation of interleukin-1 beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "activation of interleukin-1 beta production" NARROW [] synonym: "positive regulation of IL-1 beta production" EXACT [] synonym: "stimulation of interleukin-1 beta production" NARROW [] synonym: "up regulation of interleukin-1 beta production" EXACT [] synonym: "up-regulation of interleukin-1 beta production" EXACT [] synonym: "upregulation of interleukin-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032732 ! positive regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032611 ! interleukin-1 beta production relationship: positively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032732 name: positive regulation of interleukin-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "activation of interleukin-1 production" NARROW [] synonym: "positive regulation of IL-1 production" EXACT [] synonym: "stimulation of interleukin-1 production" NARROW [] synonym: "up regulation of interleukin-1 production" EXACT [] synonym: "up-regulation of interleukin-1 production" EXACT [] synonym: "upregulation of interleukin-1 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032612 ! interleukin-1 production relationship: positively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032733 name: positive regulation of interleukin-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "activation of interleukin-10 production" NARROW [] synonym: "positive regulation of IL-10 production" EXACT [] synonym: "stimulation of interleukin-10 production" NARROW [] synonym: "up regulation of interleukin-10 production" EXACT [] synonym: "up-regulation of interleukin-10 production" EXACT [] synonym: "upregulation of interleukin-10 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032613 ! interleukin-10 production relationship: positively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032734 name: positive regulation of interleukin-11 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "activation of interleukin-11 production" NARROW [] synonym: "positive regulation of IL-11 production" EXACT [] synonym: "stimulation of interleukin-11 production" NARROW [] synonym: "up regulation of interleukin-11 production" EXACT [] synonym: "up-regulation of interleukin-11 production" EXACT [] synonym: "upregulation of interleukin-11 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032614 ! interleukin-11 production relationship: positively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032735 name: positive regulation of interleukin-12 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "activation of interleukin-12 production" NARROW [] synonym: "positive regulation of IL-12 production" EXACT [] synonym: "stimulation of interleukin-12 production" NARROW [] synonym: "up regulation of interleukin-12 production" EXACT [] synonym: "up-regulation of interleukin-12 production" EXACT [] synonym: "upregulation of interleukin-12 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032615 ! interleukin-12 production relationship: positively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032736 name: positive regulation of interleukin-13 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "activation of interleukin-13 production" NARROW [] synonym: "positive regulation of IL-13 production" EXACT [] synonym: "stimulation of interleukin-13 production" NARROW [] synonym: "up regulation of interleukin-13 production" EXACT [] synonym: "up-regulation of interleukin-13 production" EXACT [] synonym: "upregulation of interleukin-13 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032616 ! interleukin-13 production relationship: positively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032737 name: positive regulation of interleukin-14 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "activation of interleukin-14 production" NARROW [] synonym: "positive regulation of IL-14 production" EXACT [] synonym: "stimulation of interleukin-14 production" NARROW [] synonym: "up regulation of interleukin-14 production" EXACT [] synonym: "up-regulation of interleukin-14 production" EXACT [] synonym: "upregulation of interleukin-14 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032617 ! interleukin-14 production relationship: positively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032738 name: positive regulation of interleukin-15 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "activation of interleukin-15 production" NARROW [] synonym: "positive regulation of IL-15 production" EXACT [] synonym: "stimulation of interleukin-15 production" NARROW [] synonym: "up regulation of interleukin-15 production" EXACT [] synonym: "up-regulation of interleukin-15 production" EXACT [] synonym: "upregulation of interleukin-15 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032618 ! interleukin-15 production relationship: positively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032739 name: positive regulation of interleukin-16 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "activation of interleukin-16 production" NARROW [] synonym: "positive regulation of IL-16 production" EXACT [] synonym: "stimulation of interleukin-16 production" NARROW [] synonym: "up regulation of interleukin-16 production" EXACT [] synonym: "up-regulation of interleukin-16 production" EXACT [] synonym: "upregulation of interleukin-16 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032619 ! interleukin-16 production relationship: positively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032740 name: positive regulation of interleukin-17 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "activation of interleukin-17 production" NARROW [] synonym: "positive regulation of IL-17 production" EXACT [] synonym: "stimulation of interleukin-17 production" NARROW [] synonym: "up regulation of interleukin-17 production" EXACT [] synonym: "up-regulation of interleukin-17 production" EXACT [] synonym: "upregulation of interleukin-17 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032620 ! interleukin-17 production relationship: positively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032741 name: positive regulation of interleukin-18 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "activation of interleukin-18 production" NARROW [] synonym: "positive regulation of IL-18 production" EXACT [] synonym: "stimulation of interleukin-18 production" NARROW [] synonym: "up regulation of interleukin-18 production" EXACT [] synonym: "up-regulation of interleukin-18 production" EXACT [] synonym: "upregulation of interleukin-18 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032621 ! interleukin-18 production relationship: positively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032742 name: positive regulation of interleukin-19 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "activation of interleukin-19 production" NARROW [] synonym: "positive regulation of IL-19 production" EXACT [] synonym: "stimulation of interleukin-19 production" NARROW [] synonym: "up regulation of interleukin-19 production" EXACT [] synonym: "up-regulation of interleukin-19 production" EXACT [] synonym: "upregulation of interleukin-19 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032622 ! interleukin-19 production relationship: positively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032743 name: positive regulation of interleukin-2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "activation of interleukin-2 production" NARROW [] synonym: "positive regulation of IL-2 production" EXACT [] synonym: "stimulation of interleukin-2 production" NARROW [] synonym: "up regulation of interleukin-2 production" EXACT [] synonym: "up-regulation of interleukin-2 production" EXACT [] synonym: "upregulation of interleukin-2 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032623 ! interleukin-2 production relationship: positively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032744 name: positive regulation of interleukin-20 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "activation of interleukin-20 production" NARROW [] synonym: "positive regulation of IL-20 production" EXACT [] synonym: "stimulation of interleukin-20 production" NARROW [] synonym: "up regulation of interleukin-20 production" EXACT [] synonym: "up-regulation of interleukin-20 production" EXACT [] synonym: "upregulation of interleukin-20 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032624 ! interleukin-20 production relationship: positively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032745 name: positive regulation of interleukin-21 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "activation of interleukin-21 production" NARROW [] synonym: "positive regulation of IL-21 production" EXACT [] synonym: "stimulation of interleukin-21 production" NARROW [] synonym: "up regulation of interleukin-21 production" EXACT [] synonym: "up-regulation of interleukin-21 production" EXACT [] synonym: "upregulation of interleukin-21 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032625 ! interleukin-21 production relationship: positively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032746 name: positive regulation of interleukin-22 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "activation of interleukin-22 production" NARROW [] synonym: "positive regulation of IL-22 production" EXACT [] synonym: "stimulation of interleukin-22 production" NARROW [] synonym: "up regulation of interleukin-22 production" EXACT [] synonym: "up-regulation of interleukin-22 production" EXACT [] synonym: "upregulation of interleukin-22 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032626 ! interleukin-22 production relationship: positively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032747 name: positive regulation of interleukin-23 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "activation of interleukin-23 production" NARROW [] synonym: "positive regulation of IL-23 production" EXACT [] synonym: "stimulation of interleukin-23 production" NARROW [] synonym: "up regulation of interleukin-23 production" EXACT [] synonym: "up-regulation of interleukin-23 production" EXACT [] synonym: "upregulation of interleukin-23 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032627 ! interleukin-23 production relationship: positively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032748 name: positive regulation of interleukin-24 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "activation of interleukin-24 production" NARROW [] synonym: "positive regulation of IL-24 production" EXACT [] synonym: "stimulation of interleukin-24 production" NARROW [] synonym: "up regulation of interleukin-24 production" EXACT [] synonym: "up-regulation of interleukin-24 production" EXACT [] synonym: "upregulation of interleukin-24 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032628 ! interleukin-24 production relationship: positively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032749 name: positive regulation of interleukin-25 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "activation of interleukin-25 production" NARROW [] synonym: "positive regulation of IL-25 production" EXACT [] synonym: "stimulation of interleukin-25 production" NARROW [] synonym: "up regulation of interleukin-25 production" EXACT [] synonym: "up-regulation of interleukin-25 production" EXACT [] synonym: "upregulation of interleukin-25 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032629 ! interleukin-25 production relationship: positively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032750 name: positive regulation of interleukin-26 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "activation of interleukin-26 production" NARROW [] synonym: "positive regulation of IL-26 production" EXACT [] synonym: "stimulation of interleukin-26 production" NARROW [] synonym: "up regulation of interleukin-26 production" EXACT [] synonym: "up-regulation of interleukin-26 production" EXACT [] synonym: "upregulation of interleukin-26 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032630 ! interleukin-26 production relationship: positively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032751 name: positive regulation of interleukin-27 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "activation of interleukin-27 production" NARROW [] synonym: "positive regulation of IL-27 production" EXACT [] synonym: "stimulation of interleukin-27 production" NARROW [] synonym: "up regulation of interleukin-27 production" EXACT [] synonym: "up-regulation of interleukin-27 production" EXACT [] synonym: "upregulation of interleukin-27 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032631 ! interleukin-27 production relationship: positively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032752 name: positive regulation of interleukin-3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "activation of interleukin-3 production" NARROW [] synonym: "positive regulation of IL-3 production" EXACT [] synonym: "stimulation of interleukin-3 production" NARROW [] synonym: "up regulation of interleukin-3 production" EXACT [] synonym: "up-regulation of interleukin-3 production" EXACT [] synonym: "upregulation of interleukin-3 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032632 ! interleukin-3 production relationship: positively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032753 name: positive regulation of interleukin-4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "activation of interleukin-4 production" NARROW [] synonym: "positive regulation of IL-4 production" EXACT [] synonym: "stimulation of interleukin-4 production" NARROW [] synonym: "up regulation of interleukin-4 production" EXACT [] synonym: "up-regulation of interleukin-4 production" EXACT [] synonym: "upregulation of interleukin-4 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032633 ! interleukin-4 production relationship: positively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032754 name: positive regulation of interleukin-5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "activation of interleukin-5 production" NARROW [] synonym: "positive regulation of IL-5 production" EXACT [] synonym: "stimulation of interleukin-5 production" NARROW [] synonym: "up regulation of interleukin-5 production" EXACT [] synonym: "up-regulation of interleukin-5 production" EXACT [] synonym: "upregulation of interleukin-5 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032634 ! interleukin-5 production relationship: positively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032755 name: positive regulation of interleukin-6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "activation of interleukin-6 production" NARROW [] synonym: "positive regulation of IL-6 production" EXACT [] synonym: "stimulation of interleukin-6 production" NARROW [] synonym: "up regulation of interleukin-6 production" EXACT [] synonym: "up-regulation of interleukin-6 production" EXACT [] synonym: "upregulation of interleukin-6 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032635 ! interleukin-6 production relationship: positively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032756 name: positive regulation of interleukin-7 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "activation of interleukin-7 production" NARROW [] synonym: "positive regulation of IL-7 production" EXACT [] synonym: "stimulation of interleukin-7 production" NARROW [] synonym: "up regulation of interleukin-7 production" EXACT [] synonym: "up-regulation of interleukin-7 production" EXACT [] synonym: "upregulation of interleukin-7 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032636 ! interleukin-7 production relationship: positively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032757 name: positive regulation of interleukin-8 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "activation of interleukin-8 production" NARROW [] synonym: "positive regulation of IL-8 production" EXACT [] synonym: "stimulation of interleukin-8 production" NARROW [] synonym: "up regulation of interleukin-8 production" EXACT [] synonym: "up-regulation of interleukin-8 production" EXACT [] synonym: "upregulation of interleukin-8 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032637 ! interleukin-8 production relationship: positively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032758 name: positive regulation of interleukin-9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "activation of interleukin-9 production" NARROW [] synonym: "positive regulation of IL-9 production" EXACT [] synonym: "stimulation of interleukin-9 production" NARROW [] synonym: "up regulation of interleukin-9 production" EXACT [] synonym: "up-regulation of interleukin-9 production" EXACT [] synonym: "upregulation of interleukin-9 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032638 ! interleukin-9 production relationship: positively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032759 name: positive regulation of TRAIL production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "activation of TRAIL production" NARROW [] synonym: "stimulation of TRAIL production" NARROW [] synonym: "up regulation of TRAIL production" EXACT [] synonym: "up-regulation of TRAIL production" EXACT [] synonym: "upregulation of TRAIL production" EXACT [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032639 ! TRAIL production relationship: positively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032760 name: positive regulation of tumor necrosis factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor production" NARROW [] synonym: "positive regulation of TNF production" EXACT [] synonym: "positive regulation of TNF-alpha production" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] synonym: "stimulation of tumor necrosis factor production" NARROW [] synonym: "up regulation of tumor necrosis factor production" EXACT [] synonym: "up-regulation of tumor necrosis factor production" EXACT [] synonym: "upregulation of tumor necrosis factor production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032640 ! tumor necrosis factor production relationship: positively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032761 name: positive regulation of lymphotoxin A production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "activation of lymphotoxin A production" NARROW [] synonym: "positive regulation of LTA production" EXACT [] synonym: "positive regulation of lymphotoxin-alpha production" EXACT [] synonym: "positive regulation of TNF-beta production" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta production" EXACT [] synonym: "stimulation of lymphotoxin A production" NARROW [] synonym: "up regulation of lymphotoxin A production" EXACT [] synonym: "up-regulation of lymphotoxin A production" EXACT [] synonym: "upregulation of lymphotoxin A production" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032641 ! lymphotoxin A production relationship: positively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032762 name: mast cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0032763 name: regulation of mast cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032762 ! mast cell cytokine production relationship: regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032764 name: negative regulation of mast cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "down regulation of mast cell cytokine production" EXACT [] synonym: "down-regulation of mast cell cytokine production" EXACT [] synonym: "downregulation of mast cell cytokine production" EXACT [] synonym: "inhibition of mast cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0032763 ! regulation of mast cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032762 ! mast cell cytokine production relationship: negatively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032765 name: positive regulation of mast cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "activation of mast cell cytokine production" NARROW [] synonym: "stimulation of mast cell cytokine production" NARROW [] synonym: "up regulation of mast cell cytokine production" EXACT [] synonym: "up-regulation of mast cell cytokine production" EXACT [] synonym: "upregulation of mast cell cytokine production" EXACT [] is_a: GO:0032763 ! regulation of mast cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032762 ! mast cell cytokine production relationship: positively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032766 name: NHE3/E3KARP/ACTN4 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032767 name: copper-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690] is_a: GO:0005515 ! protein binding [Term] id: GO:0032768 name: regulation of monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of a monooxygenase." [GOC:mah] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004497 ! monooxygenase activity relationship: regulates GO:0004497 ! monooxygenase activity [Term] id: GO:0032769 name: negative regulation of monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah] synonym: "down regulation of monooxygenase activity" EXACT [] synonym: "down-regulation of monooxygenase activity" EXACT [] synonym: "downregulation of monooxygenase activity" EXACT [] synonym: "inhibition of monooxygenase activity" NARROW [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051354 ! negative regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004497 ! monooxygenase activity relationship: negatively_regulates GO:0004497 ! monooxygenase activity [Term] id: GO:0032770 name: positive regulation of monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah] synonym: "activation of monooxygenase activity" NARROW [] synonym: "stimulation of monooxygenase activity" NARROW [] synonym: "up regulation of monooxygenase activity" EXACT [] synonym: "up-regulation of monooxygenase activity" EXACT [] synonym: "upregulation of monooxygenase activity" EXACT [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004497 ! monooxygenase activity relationship: positively_regulates GO:0004497 ! monooxygenase activity [Term] id: GO:0032771 name: regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004503 ! monophenol monooxygenase activity relationship: regulates GO:0004503 ! monophenol monooxygenase activity [Term] id: GO:0032772 name: negative regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of monophenol oxygenase activity" EXACT [] synonym: "down-regulation of monophenol oxygenase activity" EXACT [] synonym: "downregulation of monophenol oxygenase activity" EXACT [] synonym: "inhibition of monophenol oxygenase activity" NARROW [] synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004503 ! monophenol monooxygenase activity relationship: negatively_regulates GO:0004503 ! monophenol monooxygenase activity [Term] id: GO:0032773 name: positive regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "activation of monophenol oxygenase activity" NARROW [] synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] synonym: "stimulation of monophenol oxygenase activity" NARROW [] synonym: "up regulation of monophenol oxygenase activity" EXACT [] synonym: "up-regulation of monophenol oxygenase activity" EXACT [] synonym: "upregulation of monophenol oxygenase activity" EXACT [] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004503 ! monophenol monooxygenase activity relationship: positively_regulates GO:0004503 ! monophenol monooxygenase activity [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process [Term] id: GO:0032775 name: DNA methylation on adenine namespace: biological_process def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf] synonym: "adenine methylation" RELATED [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032776 name: DNA methylation on cytosine namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf] synonym: "cytosine methylation" BROAD [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032777 name: Piccolo NuA4 histone acetyltransferase complex namespace: cellular_component def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809] is_a: GO:0035267 ! NuA4 histone acetyltransferase complex [Term] id: GO:0032778 name: ATPase-coupled cobalt transmembrane transporter activity namespace: molecular_function alt_id: GO:0015632 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] synonym: "ATP-dependent cobalt transmembrane transporter activity" EXACT [] synonym: "cobalt ABC transporter" RELATED [] synonym: "cobalt porter activity" RELATED [] synonym: "cobalt transporting ATPase activity" EXACT [] synonym: "cobalt-transporting ATPase activity" EXACT [] xref: RHEA:32779 is_a: GO:0015087 ! cobalt ion transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity [Term] id: GO:0032780 name: negative regulation of ATPase activity namespace: biological_process def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "down regulation of ATPase activity" EXACT [] synonym: "down-regulation of ATPase activity" EXACT [] synonym: "downregulation of ATPase activity" EXACT [] synonym: "inhibition of ATPase activity" NARROW [] synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016887 ! ATPase activity relationship: negatively_regulates GO:0016887 ! ATPase activity [Term] id: GO:0032781 name: positive regulation of ATPase activity namespace: biological_process def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "activation of ATPase activity" NARROW [] synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] synonym: "stimulation of ATPase activity" NARROW [] synonym: "up regulation of ATPase activity" EXACT [] synonym: "up-regulation of ATPase activity" EXACT [] synonym: "upregulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016887 ! ATPase activity relationship: positively_regulates GO:0016887 ! ATPase activity [Term] id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0032783 name: ELL-EAF complex namespace: cellular_component def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032784 name: regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "regulation of RNA elongation" BROAD [] synonym: "regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "regulation of transcriptional elongation" BROAD [] synonym: "transcription elongation regulator activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006354 ! DNA-templated transcription, elongation relationship: regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032785 name: negative regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "down regulation of RNA elongation" BROAD [] synonym: "down-regulation of RNA elongation" BROAD [] synonym: "downregulation of RNA elongation" BROAD [] synonym: "inhibition of RNA elongation" BROAD [] synonym: "negative regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "negative regulation of transcription elongation" BROAD [] synonym: "negative regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "negative regulation of transcriptional elongation" BROAD [] synonym: "negative transcription elongation regulator activity" RELATED [] is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation relationship: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032786 name: positive regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "activation of RNA elongation" BROAD [] synonym: "positive regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "positive regulation of transcription elongation" BROAD [] synonym: "positive regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "positive regulation of transcriptional elongation" BROAD [] synonym: "positive transcription elongation regulator activity" RELATED [] synonym: "stimulation of RNA elongation" BROAD [] synonym: "up regulation of RNA elongation" BROAD [] synonym: "up-regulation of RNA elongation" BROAD [] synonym: "upregulation of RNA elongation" BROAD [] is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006354 ! DNA-templated transcription, elongation relationship: positively_regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0032788 name: saturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk] synonym: "saturated monocarboxylate metabolic process" EXACT [] synonym: "saturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032789 name: unsaturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk] synonym: "unsaturated monocarboxylate metabolic process" EXACT [] synonym: "unsaturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] is_a: GO:1903008 ! organelle disassembly [Term] id: GO:0032791 name: lead ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lead (Pb) ions." [GOC:mah] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0032792 name: negative regulation of CREB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "CREB inhibitor" RELATED [] synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb] is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity [Term] id: GO:0032793 name: positive regulation of CREB transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "activation of CREB" EXACT [] synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "CREB activator" RELATED [] is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity [Term] id: GO:0032794 name: GTPase activating protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] synonym: "GAP binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0032795 name: heterotrimeric G-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heterotrimeric G-protein." [GOC:nln] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0032796 name: uropod organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "uropod organisation" EXACT [GOC:mah] synonym: "uropod organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0032797 name: SMN complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. synonym: "SMN core complex" EXACT [] synonym: "survival motor neuron complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032798 name: Swi5-Sfr1 complex namespace: cellular_component def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw] synonym: "Swi5 complex" BROAD [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0032799 name: low-density lipoprotein receptor particle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk] synonym: "LDL receptor metabolic process" EXACT [] synonym: "low-density lipoprotein receptor metabolic process" EXACT [GOC:bf, GOC:dph] synonym: "low-density lipoprotein receptor metabolism" EXACT [] is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032800 name: receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor anabolism" EXACT [] synonym: "receptor biosynthesis" EXACT [] synonym: "receptor formation" EXACT [] synonym: "receptor synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032801 name: receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor breakdown" EXACT [] synonym: "receptor catabolism" EXACT [] synonym: "receptor degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0043112 ! receptor metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0032802 name: low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "LDL receptor breakdown" EXACT [] synonym: "LDL receptor catabolic process" EXACT [] synonym: "LDL receptor catabolism" RELATED [] synonym: "LDL receptor degradation" EXACT [] synonym: "low-density lipoprotein receptor breakdown" EXACT [] synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "low-density lipoprotein receptor catabolism" EXACT [] synonym: "low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process is_a: GO:0032801 ! receptor catabolic process is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0032803 name: regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "regulation of LDLr catabolic process" EXACT [] synonym: "regulation of LDLr catabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:1903362 ! regulation of cellular protein catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032804 name: negative regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:1903363 ! negative regulation of cellular protein catabolic process is_a: GO:2000645 ! negative regulation of receptor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032805 name: positive regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT [] synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT [] is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:1903364 ! positive regulation of cellular protein catabolic process is_a: GO:2000646 ! positive regulation of receptor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032806 name: carboxy-terminal domain protein kinase complex namespace: cellular_component def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] synonym: "CTDK complex" EXACT [] is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032807 name: DNA ligase IV complex namespace: cellular_component def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0032808 name: lacrimal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0032809 name: neuronal cell body membrane namespace: cellular_component def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl] synonym: "neuron cell body membrane" EXACT [] synonym: "neuronal cell soma membrane" EXACT [] is_a: GO:0044298 ! cell body membrane relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0032810 name: sterol response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "SRE binding" EXACT [] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding [Term] id: GO:0032811 name: negative regulation of epinephrine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "down regulation of epinephrine secretion" EXACT [] synonym: "down-regulation of epinephrine secretion" EXACT [] synonym: "downregulation of epinephrine secretion" EXACT [] synonym: "inhibition of epinephrine secretion" NARROW [] synonym: "negative regulation of adrenaline secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048242 ! epinephrine secretion relationship: negatively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032812 name: positive regulation of epinephrine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "activation of epinephrine secretion" NARROW [] synonym: "positive regulation of adrenaline secretion" EXACT [] synonym: "stimulation of epinephrine secretion" NARROW [] synonym: "up regulation of epinephrine secretion" EXACT [] synonym: "up-regulation of epinephrine secretion" EXACT [] synonym: "upregulation of epinephrine secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048242 ! epinephrine secretion relationship: positively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032813 name: tumor necrosis factor receptor superfamily binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily." [GOC:add] synonym: "TNF receptor superfamily binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032814 name: regulation of natural killer cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "regulation of NK cell activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030101 ! natural killer cell activation relationship: regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032815 name: negative regulation of natural killer cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "down regulation of natural killer cell activation" EXACT [] synonym: "down-regulation of natural killer cell activation" EXACT [] synonym: "downregulation of natural killer cell activation" EXACT [] synonym: "inhibition of natural killer cell activation" NARROW [] synonym: "negative regulation of NK cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030101 ! natural killer cell activation relationship: negatively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "activation of natural killer cell activation" NARROW [] synonym: "positive regulation of NK cell activation" EXACT [] synonym: "stimulation of natural killer cell activation" NARROW [] synonym: "up regulation of natural killer cell activation" EXACT [] synonym: "up-regulation of natural killer cell activation" EXACT [] synonym: "upregulation of natural killer cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030101 ! natural killer cell activation relationship: positively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032817 name: regulation of natural killer cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "regulation of NK cell proliferation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0050670 ! regulation of lymphocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001787 ! natural killer cell proliferation relationship: regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032818 name: negative regulation of natural killer cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "down regulation of natural killer cell proliferation" EXACT [] synonym: "down-regulation of natural killer cell proliferation" EXACT [] synonym: "downregulation of natural killer cell proliferation" EXACT [] synonym: "inhibition of natural killer cell proliferation" NARROW [] synonym: "negative regulation of NK cell proliferation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001787 ! natural killer cell proliferation relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032819 name: positive regulation of natural killer cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "activation of natural killer cell proliferation" NARROW [] synonym: "positive regulation of NK cell proliferation" EXACT [] synonym: "stimulation of natural killer cell proliferation" NARROW [] synonym: "up regulation of natural killer cell proliferation" EXACT [] synonym: "up-regulation of natural killer cell proliferation" EXACT [] synonym: "upregulation of natural killer cell proliferation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001787 ! natural killer cell proliferation relationship: positively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032820 name: regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002324 ! natural killer cell proliferation involved in immune response relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032821 name: negative regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "down regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "downregulation of natural killer cell proliferation during immune response" RELATED [] synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032818 ! negative regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032822 name: positive regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "activation of natural killer cell proliferation during immune response" NARROW [] synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell proliferation during immune response" RELATED [] synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] synonym: "up regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "upregulation of natural killer cell proliferation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032819 ! positive regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032823 name: regulation of natural killer cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development" RELATED [GOC:add] synonym: "regulation of NK cell differentiation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0045619 ! regulation of lymphocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001779 ! natural killer cell differentiation relationship: regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032824 name: negative regulation of natural killer cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation" EXACT [] synonym: "down-regulation of natural killer cell differentiation" EXACT [] synonym: "downregulation of natural killer cell differentiation" EXACT [] synonym: "inhibition of natural killer cell differentiation" NARROW [] synonym: "negative regulation of natural killer cell development" RELATED [GOC:add] synonym: "negative regulation of NK cell differentiation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001779 ! natural killer cell differentiation relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032825 name: positive regulation of natural killer cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation" NARROW [] synonym: "positive regulation of natural killer cell development" RELATED [GOC:add] synonym: "positive regulation of NK cell differentiation" EXACT [] synonym: "stimulation of natural killer cell differentiation" NARROW [] synonym: "up regulation of natural killer cell differentiation" EXACT [] synonym: "up-regulation of natural killer cell differentiation" EXACT [] synonym: "upregulation of natural killer cell differentiation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001779 ! natural killer cell differentiation relationship: positively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032826 name: regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002325 ! natural killer cell differentiation involved in immune response relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032827 name: negative regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "downregulation of natural killer cell differentiation during immune response" RELATED [] synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032824 ! negative regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032828 name: positive regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation during immune response" NARROW [] synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell differentiation during immune response" RELATED [] synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] synonym: "up regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "upregulation of natural killer cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032825 ! positive regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032829 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032830 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032831 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032832 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032833 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032834 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032835 name: glomerulus development namespace: biological_process def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "glomerular development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0032836 name: glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0032837 name: distributive segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] is_a: GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032839 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0030425 ! dendrite relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0032840 name: intramolecular proline-rich ligand binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proline-rich region within the same polypeptide." [GOC:pf] synonym: "intramolecular proline-rich region binding" EXACT [] is_a: GO:0043621 ! protein self-association is_a: GO:0070064 ! proline-rich region binding [Term] id: GO:0032841 name: calcitonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] is_a: GO:0008144 ! drug binding is_a: GO:0097644 ! calcitonin family binding [Term] id: GO:0032843 name: hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833] is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0032847 name: regulation of cellular pH reduction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "regulation of cell pH reduction" EXACT [] synonym: "regulation of cellular acidification" EXACT [] synonym: "regulation of intracellular acidification" RELATED [] synonym: "regulation of intracellular pH reduction" EXACT [] synonym: "regulation of reduction of cellular pH" EXACT [] synonym: "regulation of reduction of pH in cell" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051453 ! regulation of intracellular pH intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051452 ! intracellular pH reduction relationship: regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032848 name: negative regulation of cellular pH reduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "down regulation of cellular pH reduction" EXACT [] synonym: "down-regulation of cellular pH reduction" EXACT [] synonym: "downregulation of cellular pH reduction" EXACT [] synonym: "inhibition of cellular pH reduction" NARROW [] synonym: "negative regulation of cell pH reduction" EXACT [] synonym: "negative regulation of cellular acidification" EXACT [] synonym: "negative regulation of intracellular acidification" RELATED [] synonym: "negative regulation of intracellular pH reduction" EXACT [] synonym: "negative regulation of reduction of cellular pH" EXACT [] synonym: "negative regulation of reduction of pH in cell" EXACT [] is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051454 ! intracellular pH elevation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051452 ! intracellular pH reduction relationship: negatively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032849 name: positive regulation of cellular pH reduction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "activation of cellular pH reduction" NARROW [] synonym: "positive regulation of cell pH reduction" EXACT [] synonym: "positive regulation of cellular acidification" EXACT [] synonym: "positive regulation of intracellular acidification" RELATED [] synonym: "positive regulation of intracellular pH reduction" EXACT [] synonym: "positive regulation of reduction of cellular pH" EXACT [] synonym: "positive regulation of reduction of pH in cell" EXACT [] synonym: "stimulation of cellular pH reduction" NARROW [] synonym: "up regulation of cellular pH reduction" EXACT [] synonym: "up-regulation of cellular pH reduction" EXACT [] synonym: "upregulation of cellular pH reduction" EXACT [] is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051452 ! intracellular pH reduction relationship: positively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032865 name: ERMES complex namespace: cellular_component def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461] synonym: "ER-mitochondria encounter structure" EXACT [] synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT [] synonym: "mitochore" EXACT [GOC:mcc] synonym: "MMM1 complex" EXACT [GOC:mcc] is_a: GO:0098799 ! outer mitochondrial membrane protein complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0044233 ! mitochondria-associated endoplasmic reticulum membrane [Term] id: GO:0032866 name: D-xylose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "D-xylose reductase activity" BROAD [] synonym: "xylose reductase activity" BROAD [] xref: EC:1.1.1 xref: MetaCyc:RXN-8773 xref: RHEA:27445 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032867 name: L-arabinose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "arabinose reductase activity" BROAD [] synonym: "arabinose:NADP reductase activity" BROAD [] xref: EC:1.1.1 xref: KEGG_REACTION:R01759 xref: MetaCyc:RXN-8772 xref: SABIO-RK:1858 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032868 name: response to insulin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] synonym: "response to insulin stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] is_a: GO:0032868 ! response to insulin is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000741 ! karyogamy relationship: regulates GO:0000741 ! karyogamy [Term] id: GO:0032872 name: regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "regulation of p38 MAPK signaling" EXACT [] synonym: "regulation of p38 MAPK signalling" EXACT [] synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051403 ! stress-activated MAPK cascade relationship: regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032873 name: negative regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "down regulation of stress-activated MAPK cascade" EXACT [] synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] synonym: "downregulation of stress-activated MAPK cascade" EXACT [] synonym: "inhibition of stress-activated MAPK cascade" NARROW [] synonym: "negative regulation of p38 MAPK signaling" EXACT [] synonym: "negative regulation of p38 MAPK signalling" EXACT [] synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051403 ! stress-activated MAPK cascade relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032874 name: positive regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "activation of stress-activated MAPK cascade" NARROW [] synonym: "positive regulation of p38 MAPK signaling" EXACT [] synonym: "positive regulation of p38 MAPK signalling" EXACT [] synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] synonym: "stimulation of stress-activated MAPK cascade" NARROW [] synonym: "up regulation of stress-activated MAPK cascade" EXACT [] synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] synonym: "upregulation of stress-activated MAPK cascade" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051403 ! stress-activated MAPK cascade relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032875 name: regulation of DNA endoreduplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "regulation of DNA endoreplication" EXACT [] synonym: "regulation of DNA re-duplication" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042023 ! DNA endoreduplication relationship: regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032876 name: negative regulation of DNA endoreduplication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "down regulation of DNA endoreduplication" EXACT [] synonym: "down-regulation of DNA endoreduplication" EXACT [] synonym: "downregulation of DNA endoreduplication" EXACT [] synonym: "inhibition of DNA endoreduplication" NARROW [] synonym: "negative regulation of DNA endoreplication" EXACT [] synonym: "negative regulation of DNA re-duplication" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042023 ! DNA endoreduplication relationship: negatively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032877 name: positive regulation of DNA endoreduplication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "activation of DNA endoreduplication" NARROW [] synonym: "positive regulation of DNA endoreplication" EXACT [] synonym: "positive regulation of DNA re-duplication" EXACT [] synonym: "stimulation of DNA endoreduplication" NARROW [] synonym: "up regulation of DNA endoreduplication" EXACT [] synonym: "up-regulation of DNA endoreduplication" EXACT [] synonym: "upregulation of DNA endoreduplication" EXACT [] is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042023 ! DNA endoreduplication relationship: positively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051179 ! localization relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008104 ! protein localization relationship: regulates GO:0008104 ! protein localization [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005976 ! polysaccharide metabolic process relationship: regulates GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0032882 name: regulation of chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] synonym: "regulation of chitin metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006030 ! chitin metabolic process relationship: regulates GO:0006030 ! chitin metabolic process [Term] id: GO:0032883 name: regulation of chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah] synonym: "regulation of chitin anabolism" EXACT [] synonym: "regulation of chitin biosynthesis" RELATED [] synonym: "regulation of chitin formation" EXACT [] synonym: "regulation of chitin synthesis" EXACT [] is_a: GO:0032882 ! regulation of chitin metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006031 ! chitin biosynthetic process relationship: regulates GO:0006031 ! chitin biosynthetic process [Term] id: GO:0032884 name: regulation of cell wall chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah] synonym: "regulation of cell wall chitin anabolism" EXACT [] synonym: "regulation of cell wall chitin biosynthesis" EXACT [] synonym: "regulation of cell wall chitin formation" EXACT [] synonym: "regulation of cell wall chitin synthesis" EXACT [] is_a: GO:0032883 ! regulation of chitin biosynthetic process is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006038 ! cell wall chitin biosynthetic process relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000271 ! polysaccharide biosynthetic process relationship: regulates GO:0000271 ! polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007017 ! microtubule-based process relationship: regulates GO:0007017 ! microtubule-based process [Term] id: GO:0032887 name: regulation of spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051231 ! spindle elongation relationship: regulates GO:0051231 ! spindle elongation [Term] id: GO:0032888 name: regulation of mitotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0060236 ! regulation of mitotic spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000022 ! mitotic spindle elongation relationship: regulates GO:0000022 ! mitotic spindle elongation [Term] id: GO:0032889 name: regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah] is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042144 ! vacuole fusion, non-autophagic relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015849 ! organic acid transport relationship: regulates GO:0015849 ! organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015849 ! organic acid transport relationship: negatively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015849 ! organic acid transport relationship: positively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032896 name: palmitoyl-CoA 9-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv] synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0032897 name: negative regulation of viral transcription namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah] synonym: "down regulation of viral transcription" EXACT [] synonym: "down-regulation of viral transcription" EXACT [] synonym: "downregulation of viral transcription" EXACT [] synonym: "inhibition of viral transcription" NARROW [] is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0048525 ! negative regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019083 ! viral transcription relationship: negatively_regulates GO:0019083 ! viral transcription [Term] id: GO:0032898 name: neurotrophin production namespace: biological_process def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032899 name: regulation of neurotrophin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032898 ! neurotrophin production relationship: regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032900 name: negative regulation of neurotrophin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "down regulation of neurotrophin production" EXACT [] synonym: "down-regulation of neurotrophin production" EXACT [] synonym: "downregulation of neurotrophin production" EXACT [] synonym: "inhibition of neurotrophin production" NARROW [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032898 ! neurotrophin production relationship: negatively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032901 name: positive regulation of neurotrophin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "activation of neurotrophin production" NARROW [] synonym: "stimulation of neurotrophin production" NARROW [] synonym: "up regulation of neurotrophin production" EXACT [] synonym: "up-regulation of neurotrophin production" EXACT [] synonym: "upregulation of neurotrophin production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032898 ! neurotrophin production relationship: positively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032902 name: nerve growth factor production namespace: biological_process def: "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah] synonym: "beta-nerve growth factor production" EXACT [PR:000011194] synonym: "NGF production" EXACT [] is_a: GO:0032898 ! neurotrophin production [Term] id: GO:0032903 name: regulation of nerve growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] synonym: "regulation of beta-nerve growth factor production" EXACT [PR:000011194] synonym: "regulation of NGF production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032902 ! nerve growth factor production relationship: regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032904 name: negative regulation of nerve growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] synonym: "down regulation of nerve growth factor production" EXACT [] synonym: "down-regulation of nerve growth factor production" EXACT [] synonym: "downregulation of nerve growth factor production" EXACT [] synonym: "inhibition of nerve growth factor production" NARROW [] synonym: "negative regulation of NGF production" EXACT [] is_a: GO:0032900 ! negative regulation of neurotrophin production is_a: GO:0032903 ! regulation of nerve growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032902 ! nerve growth factor production relationship: negatively_regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032905 name: transforming growth factor beta1 production namespace: biological_process def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B1 production" EXACT [] synonym: "TGFB1 production" EXACT [] synonym: "transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032906 name: transforming growth factor beta2 production namespace: biological_process def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B2 production" EXACT [] synonym: "TGFB2 production" EXACT [] synonym: "transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032907 name: transforming growth factor beta3 production namespace: biological_process def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B3 production" EXACT [] synonym: "TGFB3 production" EXACT [] synonym: "transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032908 name: regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "regulation of TGF-B1 production" EXACT [] synonym: "regulation of TGFB1 production" EXACT [] synonym: "regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032905 ! transforming growth factor beta1 production relationship: regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032909 name: regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "regulation of TGF-B2 production" EXACT [] synonym: "regulation of TGFB2 production" EXACT [] synonym: "regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032906 ! transforming growth factor beta2 production relationship: regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032910 name: regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "regulation of TGF-B3 production" EXACT [] synonym: "regulation of TGFB3 production" EXACT [] synonym: "regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032907 ! transforming growth factor beta3 production relationship: regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032911 name: negative regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "down regulation of transforming growth factor-beta1 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "downregulation of transforming growth factor-beta1 production" EXACT [] synonym: "inhibition of transforming growth factor-beta1 production" NARROW [] synonym: "negative regulation of TGF-B1 production" EXACT [] synonym: "negative regulation of TGFB1 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0032908 ! regulation of transforming growth factor beta1 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032905 ! transforming growth factor beta1 production relationship: negatively_regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032912 name: negative regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "down regulation of transforming growth factor-beta2 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "downregulation of transforming growth factor-beta2 production" EXACT [] synonym: "inhibition of transforming growth factor-beta2 production" NARROW [] synonym: "negative regulation of TGF-B2 production" EXACT [] synonym: "negative regulation of TGFB2 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0032909 ! regulation of transforming growth factor beta2 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032906 ! transforming growth factor beta2 production relationship: negatively_regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032913 name: negative regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "down regulation of transforming growth factor-beta3 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "downregulation of transforming growth factor-beta3 production" EXACT [] synonym: "inhibition of transforming growth factor-beta3 production" NARROW [] synonym: "negative regulation of TGF-B3 production" EXACT [] synonym: "negative regulation of TGFB3 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0032910 ! regulation of transforming growth factor beta3 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032907 ! transforming growth factor beta3 production relationship: negatively_regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032914 name: positive regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "activation of transforming growth factor-beta1 production" NARROW [GOC:bf] synonym: "positive regulation of TGF-B1 production" EXACT [] synonym: "positive regulation of TGFB1 production" EXACT [] synonym: "stimulation of transforming growth factor-beta1 production" NARROW [] synonym: "up regulation of transforming growth factor-beta1 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "upregulation of transforming growth factor-beta1 production" EXACT [] is_a: GO:0032908 ! regulation of transforming growth factor beta1 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032905 ! transforming growth factor beta1 production relationship: positively_regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032915 name: positive regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "activation of transforming growth factor-beta2 production" NARROW [] synonym: "positive regulation of TGF-B2 production" EXACT [] synonym: "positive regulation of TGFB2 production" EXACT [] synonym: "positive regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] synonym: "stimulation of transforming growth factor-beta2 production" NARROW [] synonym: "up regulation of transforming growth factor-beta2 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "upregulation of transforming growth factor-beta2 production" EXACT [] is_a: GO:0032909 ! regulation of transforming growth factor beta2 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032906 ! transforming growth factor beta2 production relationship: positively_regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032916 name: positive regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "activation of transforming growth factor-beta3 production" NARROW [] synonym: "positive regulation of TGF-B3 production" EXACT [] synonym: "positive regulation of TGFB3 production" EXACT [] synonym: "positive regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] synonym: "stimulation of transforming growth factor-beta3 production" NARROW [] synonym: "up regulation of transforming growth factor-beta3 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "upregulation of transforming growth factor-beta3 production" EXACT [] is_a: GO:0032910 ! regulation of transforming growth factor beta3 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032907 ! transforming growth factor beta3 production relationship: positively_regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032917 name: polyamine acetylation namespace: biological_process def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0032918 name: spermidine acetylation namespace: biological_process def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008216 ! spermidine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032919 name: spermine acetylation namespace: biological_process def: "The modification of spermine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008215 ! spermine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032920 name: putrescine acetylation namespace: biological_process def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg] is_a: GO:0009445 ! putrescine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032921 name: sarcosine oxidase complex namespace: cellular_component def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0032922 name: circadian regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] synonym: "circadian regulation of protein expression" RELATED [] synonym: "diurnal variation of gene expression" RELATED [] synonym: "diurnal variation of protein expression" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0010468 ! regulation of gene expression is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032923 name: organic phosphonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] synonym: "organophosphonate biosynthetic process" RELATED [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0032924 name: activin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] synonym: "activin receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0032925 name: regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "regulation of activin receptor signalling pathway" EXACT [] synonym: "regulation of activin signaling pathway" RELATED [] synonym: "regulation of activin signalling pathway" RELATED [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032924 ! activin receptor signaling pathway relationship: regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032926 name: negative regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "down regulation of activin receptor signaling pathway" EXACT [] synonym: "down-regulation of activin receptor signaling pathway" EXACT [] synonym: "downregulation of activin receptor signaling pathway" EXACT [] synonym: "inhibition of activin receptor signaling pathway" NARROW [] synonym: "negative regulation of activin receptor signalling pathway" EXACT [] synonym: "negative regulation of activin signaling pathway" RELATED [] synonym: "negative regulation of activin signalling pathway" RELATED [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032924 ! activin receptor signaling pathway relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032927 name: positive regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "activation of activin receptor signaling pathway" NARROW [] synonym: "positive regulation of activin receptor signalling pathway" EXACT [] synonym: "positive regulation of activin signaling pathway" RELATED [] synonym: "positive regulation of activin signalling pathway" RELATED [] synonym: "stimulation of activin receptor signaling pathway" NARROW [] synonym: "up regulation of activin receptor signaling pathway" EXACT [] synonym: "up-regulation of activin receptor signaling pathway" EXACT [] synonym: "upregulation of activin receptor signaling pathway" EXACT [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032924 ! activin receptor signaling pathway relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032928 name: regulation of superoxide anion generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0090322 ! regulation of superoxide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042554 ! superoxide anion generation relationship: regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032929 name: negative regulation of superoxide anion generation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "down regulation of superoxide release" EXACT [] synonym: "down-regulation of superoxide release" EXACT [] synonym: "downregulation of superoxide release" EXACT [] synonym: "inhibition of superoxide release" NARROW [] synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042554 ! superoxide anion generation relationship: negatively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032930 name: positive regulation of superoxide anion generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "activation of superoxide release" NARROW [] synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of superoxide release" NARROW [] synonym: "up regulation of superoxide release" EXACT [] synonym: "up-regulation of superoxide release" EXACT [] synonym: "upregulation of superoxide release" EXACT [] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042554 ! superoxide anion generation relationship: positively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032931 name: histone acetyltransferase activity (H3-K56 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0097043 ! histone H3-K56 acetylation [Term] id: GO:0032932 name: negative regulation of astral microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah] synonym: "astral microtubule stabilization" EXACT [] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060172 ! astral microtubule depolymerization relationship: negatively_regulates GO:0060172 ! astral microtubule depolymerization [Term] id: GO:0032933 name: SREBP signaling pathway namespace: biological_process alt_id: GO:0006994 alt_id: GO:0030967 alt_id: GO:0035104 def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871] synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT [] synonym: "ER to nucleus sterol response pathway" EXACT [] synonym: "ER-nuclear sterol response pathway" EXACT [] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of transcription via sterol regulatory element binding" NARROW [GOC:vw] synonym: "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW [GOC:vw] synonym: "SREBP signalling" EXACT [GOC:bf] synonym: "SREBP target gene transcriptional activation" EXACT [] synonym: "SREBP-mediated signaling pathway" RELATED [] synonym: "SREBP-mediated signalling pathway" EXACT [] synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD [] synonym: "sterol response element binding protein signaling pathway" EXACT [GOC:bf] synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0071501 ! cellular response to sterol depletion [Term] id: GO:0032934 name: sterol binding namespace: molecular_function alt_id: GO:0005498 def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah] synonym: "sterol carrier activity" RELATED [GOC:mah] is_a: GO:0005496 ! steroid binding [Term] id: GO:0032935 name: sterol sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah] synonym: "sterol-sensing domain" NARROW [] is_a: GO:0032934 ! sterol binding is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0032936 name: SREBP-SCAP complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] synonym: "Sre1-Scp1 complex" EXACT [] is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0032937 name: SREBP-SCAP-Insig complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane." [PMID:12923525] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane [Term] id: GO:0032938 name: negative regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032939 name: positive regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "activation of translation in response to oxidative stress" NARROW [] synonym: "stimulation of translation in response to oxidative stress" NARROW [] synonym: "up regulation of translation in response to oxidative stress" EXACT [] synonym: "up-regulation of translation in response to oxidative stress" EXACT [] synonym: "upregulation of translation in response to oxidative stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion [Term] id: GO:0032942 name: inositol tetrakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] xref: EC:2.7.1 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0032943 name: mononuclear cell proliferation namespace: biological_process def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "PBMC proliferation" NARROW [] synonym: "peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "regulation of PBMC proliferation" NARROW [] synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032943 ! mononuclear cell proliferation relationship: regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "negative regulation of PBMC proliferation" NARROW [] synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032943 ! mononuclear cell proliferation relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032946 name: positive regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "activation of mononuclear cell proliferation" NARROW [] synonym: "positive regulation of PBMC proliferation" NARROW [] synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] synonym: "stimulation of mononuclear cell proliferation" NARROW [] synonym: "up regulation of mononuclear cell proliferation" EXACT [] synonym: "up-regulation of mononuclear cell proliferation" EXACT [] synonym: "upregulation of mononuclear cell proliferation" EXACT [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070665 ! positive regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032943 ! mononuclear cell proliferation relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032948 name: regulation of alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah] synonym: "regulation of alpha-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030978 ! alpha-glucan metabolic process relationship: regulates GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0032949 name: regulation of alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah] synonym: "regulation of alpha-glucan anabolism" EXACT [] synonym: "regulation of alpha-glucan biosynthesis" EXACT [] synonym: "regulation of alpha-glucan formation" EXACT [] synonym: "regulation of alpha-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032948 ! regulation of alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030979 ! alpha-glucan biosynthetic process relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process [Term] id: GO:0032950 name: regulation of beta-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah] synonym: "regulation of beta-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051273 ! beta-glucan metabolic process relationship: regulates GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0032951 name: regulation of beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah] synonym: "regulation of beta-glucan anabolism" EXACT [] synonym: "regulation of beta-glucan biosynthesis" EXACT [] synonym: "regulation of beta-glucan formation" EXACT [] synonym: "regulation of beta-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032950 ! regulation of beta-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051274 ! beta-glucan biosynthetic process relationship: regulates GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0032952 name: regulation of (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans." [GOC:mah] synonym: "regulation of (1->3)-beta-D-glucan metabolism" EXACT [] synonym: "regulation of 1,3-beta-D-glucan metabolic process" EXACT [] synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD [] synonym: "regulation of 1,3-beta-glucan metabolism" EXACT [] is_a: GO:0032950 ! regulation of beta-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process relationship: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process [Term] id: GO:0032953 name: regulation of (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:mah] synonym: "regulation of 1,3-beta-glucan anabolism" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "regulation of 1,3-beta-glucan formation" EXACT [] synonym: "regulation of 1,3-beta-glucan synthesis" EXACT [] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process is_a: GO:0032952 ! regulation of (1->3)-beta-D-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process relationship: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process [Term] id: GO:0032954 name: regulation of cytokinetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah] is_a: GO:0032465 ! regulation of cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032506 ! cytokinetic process relationship: regulates GO:0032506 ! cytokinetic process [Term] id: GO:0032955 name: regulation of division septum assembly namespace: biological_process alt_id: GO:1901138 alt_id: GO:1902468 def: "Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "regulation of division septum formation" EXACT [] is_a: GO:1901891 ! regulation of cell septum assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000917 ! division septum assembly relationship: regulates GO:0000917 ! division septum assembly [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030036 ! actin cytoskeleton organization relationship: regulates GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0032957 name: inositol trisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah] synonym: "inositol trisphosphate metabolism" EXACT [] synonym: "IP3 metabolic process" EXACT [] synonym: "IP3 metabolism" EXACT [] synonym: "myo-inositol trisphosphate metabolic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0032958 name: inositol phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah] synonym: "inositol phosphate anabolism" EXACT [] synonym: "inositol phosphate biosynthesis" EXACT [] synonym: "inositol phosphate formation" EXACT [] synonym: "inositol phosphate synthesis" EXACT [] synonym: "myo-inositol phosphate biosynthetic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0032959 name: inositol trisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah] synonym: "inositol trisphosphate anabolism" EXACT [] synonym: "inositol trisphosphate biosynthesis" EXACT [] synonym: "inositol trisphosphate formation" EXACT [] synonym: "inositol trisphosphate synthesis" EXACT [] synonym: "IP3 biosynthesis" EXACT [] synonym: "IP3 biosynthetic process" EXACT [] synonym: "myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032957 ! inositol trisphosphate metabolic process is_a: GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0032960 name: regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "regulation of inositol trisphosphate anabolism" EXACT [] synonym: "regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "regulation of inositol trisphosphate formation" EXACT [] synonym: "regulation of inositol trisphosphate synthesis" EXACT [] synonym: "regulation of IP3 biosynthesis" EXACT [] synonym: "regulation of IP3 biosynthetic process" EXACT [] synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032959 ! inositol trisphosphate biosynthetic process relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032961 name: negative regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "negative regulation of inositol trisphosphate anabolism" EXACT [] synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "negative regulation of inositol trisphosphate formation" EXACT [] synonym: "negative regulation of inositol trisphosphate synthesis" EXACT [] synonym: "negative regulation of IP3 biosynthesis" EXACT [] synonym: "negative regulation of IP3 biosynthetic process" EXACT [] synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032962 name: positive regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "positive regulation of inositol trisphosphate anabolism" EXACT [] synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "positive regulation of inositol trisphosphate formation" EXACT [] synonym: "positive regulation of inositol trisphosphate synthesis" EXACT [] synonym: "positive regulation of IP3 biosynthesis" EXACT [] synonym: "positive regulation of IP3 biosynthetic process" EXACT [] synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0032963 ! collagen metabolic process [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032964 ! collagen biosynthetic process relationship: regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032964 ! collagen biosynthetic process relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032964 ! collagen biosynthetic process relationship: positively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032968 name: positive regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090040 def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter relationship: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0032969 name: endosomal scaffold complex namespace: cellular_component def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910] synonym: "endosomal adaptor complex" EXACT [GOC:hjd] synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031902 ! late endosome membrane [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030029 ! actin filament-based process relationship: regulates GO:0030029 ! actin filament-based process [Term] id: GO:0032971 name: regulation of muscle filament sliding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030049 ! muscle filament sliding relationship: regulates GO:0030049 ! muscle filament sliding [Term] id: GO:0032972 name: regulation of muscle filament sliding speed namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0032973 name: amino acid export across plasma membrane namespace: biological_process alt_id: GO:0044746 def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] synonym: "amino acid efflux" EXACT [] synonym: "amino acid export" BROAD [] synonym: "amino acid transmembrane export" BROAD [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: janelomax creation_date: 2012-11-14T14:27:40Z [Term] id: GO:0032974 name: amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] synonym: "amino acid efflux from vacuole" EXACT [] synonym: "vacuolar amino acid export" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport [Term] id: GO:0032975 name: amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] synonym: "vacuolar amino acid import" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0032976 name: release of matrix enzymes from mitochondria namespace: biological_process def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process." [GOC:mah, GOC:mtg_apoptosis, PMID:9843949] comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified. synonym: "mAST release from mitochondria" NARROW [] synonym: "release of aspartate aminotransferase from mitochondria" NARROW [] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0032977 name: membrane insertase activity namespace: molecular_function def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936] comment: Changed parent to 'molecular carrier activity', see https://github.com/geneontology/go-ontology/issues/16976 xref: Reactome:R-HSA-1268025 "SAM50 complex inserts proteins into mitochondrial outer membrane" xref: Reactome:R-HSA-1299482 "TIMM23 SORT inserts proteins into inner membrane" xref: Reactome:R-HSA-1307803 "TIMM22 inserts proteins into inner membrane" is_a: GO:0140104 ! molecular carrier activity relationship: part_of GO:0090150 ! establishment of protein localization to membrane [Term] id: GO:0032978 name: protein insertion into membrane from inner side namespace: biological_process def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843] synonym: "insertion of proteins into membrane from the inner side" EXACT [] is_a: GO:0051205 ! protein insertion into membrane [Term] id: GO:0032979 name: protein insertion into mitochondrial inner membrane from matrix namespace: biological_process def: "The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843] synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT [] synonym: "protein insertion into mitochondrial inner membrane from matrix side" EXACT [] synonym: "protein insertion into mitochondrial membrane from inner side" EXACT [] is_a: GO:0032978 ! protein insertion into membrane from inner side is_a: GO:0045039 ! protein insertion into mitochondrial inner membrane [Term] id: GO:0032980 name: keratinocyte activation namespace: biological_process def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] is_a: GO:0001775 ! cell activation [Term] id: GO:0032981 name: mitochondrial respiratory chain complex I assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] synonym: "mitochondrial complex I assembly" EXACT [] synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT [] is_a: GO:0010257 ! NADH dehydrogenase complex assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly [Term] id: GO:0032982 name: myosin filament namespace: cellular_component def: "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] synonym: "myosin thick filament" RELATED [] synonym: "thick filament" RELATED [] is_a: GO:0099512 ! supramolecular fiber relationship: has_part GO:0016459 ! myosin complex [Term] id: GO:0032983 name: kainate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034705 ! potassium channel complex is_a: GO:0034706 ! sodium channel complex [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process alt_id: GO:0034623 alt_id: GO:0043241 def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0032985 name: protein-carbohydrate complex disassembly namespace: biological_process def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071823 ! protein-carbohydrate complex subunit organization [Term] id: GO:0032986 name: protein-DNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] synonym: "DNA-protein complex disassembly" EXACT [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0032987 name: protein-lipid complex disassembly namespace: biological_process def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0032988 name: ribonucleoprotein complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "protein-RNA complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032990 name: cell part morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0032992 name: protein-carbohydrate complex namespace: cellular_component def: "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other." [GOC:mah] comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032993 name: protein-DNA complex namespace: cellular_component def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. subset: goslim_pir synonym: "DNA-protein complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032994 name: protein-lipid complex namespace: cellular_component def: "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah] comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032995 name: regulation of fungal-type cell wall biogenesis namespace: biological_process def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009272 ! fungal-type cell wall biogenesis relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0032996 name: Bcl3-Bcl10 complex namespace: cellular_component def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0032997 name: Fc receptor complex namespace: cellular_component def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149] subset: goslim_pir synonym: "Fc-receptor complex" EXACT [] synonym: "FcR complex" EXACT [] synonym: "immunoglobulin receptor complex" BROAD [] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0032998 name: Fc-epsilon receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149] synonym: "FceRI complex" EXACT [] synonym: "IgE receptor complex" BROAD [] synonym: "immunoglobulin E receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0032999 name: Fc-alpha receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149, PMID:12524384] synonym: "FcaRI complex" EXACT [] synonym: "IgA receptor complex" BROAD [] synonym: "immunoglobulin A receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033000 name: Fc-gamma receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] synonym: "FcgRI complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033001 name: Fc-gamma receptor III complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] synonym: "FcgRIII complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0033003 name: regulation of mast cell activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045576 ! mast cell activation relationship: regulates GO:0045576 ! mast cell activation [Term] id: GO:0033004 name: negative regulation of mast cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045576 ! mast cell activation relationship: negatively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033005 name: positive regulation of mast cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045576 ! mast cell activation relationship: positively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033006 name: regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0033003 ! regulation of mast cell activation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002279 ! mast cell activation involved in immune response relationship: regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033007 name: negative regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0033004 ! negative regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002279 ! mast cell activation involved in immune response relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033008 name: positive regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0033005 ! positive regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002279 ! mast cell activation involved in immune response relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033009 name: nucleomorph namespace: cellular_component def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] xref: Wikipedia:Nucleomorph is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0009536 ! plastid [Term] id: GO:0033010 name: paranodal junction namespace: cellular_component def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] synonym: "axoglial septate junction" EXACT [MP:0010735] synonym: "paranodal axoglial junction" EXACT [PMID:18803321] synonym: "paranodal septate junction" EXACT [MP:0010735] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0033011 name: perinuclear theca namespace: cellular_component def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] is_a: GO:0005856 ! cytoskeleton relationship: part_of GO:0048471 ! perinuclear region of cytoplasm [Term] id: GO:0033012 name: porosome namespace: cellular_component def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] xref: Wikipedia:Porosome is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033014 name: tetrapyrrole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole anabolism" EXACT [] synonym: "tetrapyrrole biosynthesis" EXACT [] synonym: "tetrapyrrole formation" EXACT [] synonym: "tetrapyrrole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033015 name: tetrapyrrole catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] synonym: "tetrapyrrole breakdown" EXACT [] synonym: "tetrapyrrole catabolism" EXACT [] synonym: "tetrapyrrole degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0033016 name: rhoptry membrane namespace: cellular_component def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0020008 ! rhoptry [Term] id: GO:0033017 name: sarcoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033018 name: sarcoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0016529 ! sarcoplasmic reticulum relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033019 name: 5-hydroxyvalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033020 name: cyclopentanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764] synonym: "cyclopentanol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0033021 name: cyclopentanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764] synonym: "cyclopentanol anabolism" EXACT [] synonym: "cyclopentanol biosynthesis" EXACT [] synonym: "cyclopentanol formation" EXACT [] synonym: "cyclopentanol synthesis" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0033022 name: cyclopentanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764] synonym: "cyclopentanol breakdown" EXACT [] synonym: "cyclopentanol catabolism" EXACT [] synonym: "cyclopentanol degradation" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0033023 name: mast cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0033024 name: mast cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130] synonym: "apoptosis of mast cells" EXACT [] synonym: "mast cell apoptosis" NARROW [] is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process relationship: part_of GO:0033023 ! mast cell homeostasis [Term] id: GO:0033025 name: regulation of mast cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mast cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0065008 ! regulation of biological quality is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033024 ! mast cell apoptotic process relationship: regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033026 name: negative regulation of mast cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mast cell apoptosis" EXACT [] synonym: "down-regulation of mast cell apoptosis" EXACT [] synonym: "downregulation of mast cell apoptosis" EXACT [] synonym: "inhibition of mast cell apoptosis" NARROW [] synonym: "negative regulation of mast cell apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033024 ! mast cell apoptotic process relationship: negatively_regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033027 name: positive regulation of mast cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mast cell apoptosis" NARROW [] synonym: "positive regulation of mast cell apoptosis" NARROW [] synonym: "stimulation of mast cell apoptosis" NARROW [] synonym: "up regulation of mast cell apoptosis" EXACT [] synonym: "up-regulation of mast cell apoptosis" EXACT [] synonym: "upregulation of mast cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033024 ! mast cell apoptotic process relationship: positively_regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033028 name: myeloid cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] synonym: "myeloid cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0033029 name: regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of neutrophil apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0065008 ! regulation of biological quality is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001781 ! neutrophil apoptotic process relationship: regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033030 name: negative regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of neutrophil apoptosis" EXACT [] synonym: "down-regulation of neutrophil apoptosis" EXACT [] synonym: "downregulation of neutrophil apoptosis" EXACT [] synonym: "inhibition of neutrophil apoptosis" NARROW [] synonym: "negative regulation of neutrophil apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001781 ! neutrophil apoptotic process relationship: negatively_regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033031 name: positive regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of neutrophil apoptosis" NARROW [] synonym: "positive regulation of neutrophil apoptosis" NARROW [] synonym: "stimulation of neutrophil apoptosis" NARROW [] synonym: "up regulation of neutrophil apoptosis" EXACT [] synonym: "up-regulation of neutrophil apoptosis" EXACT [] synonym: "upregulation of neutrophil apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001781 ! neutrophil apoptotic process relationship: positively_regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033032 name: regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033028 ! myeloid cell apoptotic process relationship: regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] synonym: "negative regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033028 ! myeloid cell apoptotic process relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "positive regulation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033028 ! myeloid cell apoptotic process relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0033038 name: bitter taste receptor activity namespace: molecular_function def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity relationship: part_of GO:0001580 ! detection of chemical stimulus involved in sensory perception of bitter taste [Term] id: GO:0033039 name: salty taste receptor activity namespace: molecular_function def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity relationship: part_of GO:0001583 ! detection of chemical stimulus involved in sensory perception of salty taste [Term] id: GO:0033040 name: sour taste receptor activity namespace: molecular_function def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity relationship: part_of GO:0001581 ! detection of chemical stimulus involved in sensory perception of sour taste [Term] id: GO:0033041 name: sweet taste receptor activity namespace: molecular_function def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity relationship: part_of GO:0001582 ! detection of chemical stimulus involved in sensory perception of sweet taste [Term] id: GO:0033042 name: umami taste receptor activity namespace: molecular_function def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] is_a: GO:0090681 ! GPCR taste receptor activity relationship: part_of GO:0046535 ! detection of chemical stimulus involved in sensory perception of umami taste [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006996 ! organelle organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051276 ! chromosome organization relationship: regulates GO:0051276 ! chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000819 ! sister chromatid segregation relationship: regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000819 ! sister chromatid segregation relationship: negatively_regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000070 ! mitotic sister chromatid segregation relationship: regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045839 ! negative regulation of mitotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033049 name: clavulanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah] synonym: "clavulanic acid metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033050 name: clavulanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah] synonym: "clavulanic acid anabolism" EXACT [] synonym: "clavulanic acid biosynthesis" EXACT [] synonym: "clavulanic acid formation" EXACT [] synonym: "clavulanic acid synthesis" EXACT [] xref: Wikipedia:Clavulanic_acid is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033049 ! clavulanic acid metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033051 name: aminophosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG:map00440] synonym: "aminophosphonate metabolism" EXACT [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033052 name: cyanoamino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729] synonym: "cyanoamino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0033053 name: D-glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [GOC:jsg, GOC:mah] synonym: "D-glutamine metabolism" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033054 name: D-glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [GOC:jsg, GOC:mah] synonym: "D-glutamate metabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033055 name: D-arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [GOC:jsg, GOC:mah] synonym: "D-arginine metabolism" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033056 name: D-ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [GOC:jsg, GOC:mah] synonym: "D-ornithine metabolism" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0033058 name: directional locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07] is_a: GO:0040011 ! locomotion [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033060 name: ocellus pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07] is_a: GO:0043473 ! pigmentation [Term] id: GO:0033061 name: DNA recombinase mediator complex namespace: cellular_component def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992] comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0033062 name: Rhp55-Rhp57 complex namespace: cellular_component def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] synonym: "Rad55-Rad57 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033063 name: Rad51B-Rad51C-Rad51D-XRCC2 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BCDX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033064 name: XRCC2-RAD51D complex namespace: cellular_component def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] synonym: "DX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033065 name: Rad51C-XRCC3 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "CX3 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033066 name: Rad51B-Rad51C complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BC complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033067 name: macrolide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] synonym: "macrolide metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1901334 ! lactone metabolic process [Term] id: GO:0033068 name: macrolide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] synonym: "macrolide anabolism" EXACT [] synonym: "macrolide biosynthesis" EXACT [] synonym: "macrolide formation" EXACT [] synonym: "macrolide synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033067 ! macrolide metabolic process is_a: GO:1901336 ! lactone biosynthetic process [Term] id: GO:0033069 name: ansamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] synonym: "ansamycin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033070 name: ansamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] synonym: "ansamycin anabolism" EXACT [] synonym: "ansamycin biosynthesis" EXACT [] synonym: "ansamycin formation" EXACT [] synonym: "ansamycin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033069 ! ansamycin metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033071 name: vancomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah] synonym: "vancomycin metabolism" EXACT [] is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0033072 name: vancomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah] synonym: "vancomycin anabolism" EXACT [] synonym: "vancomycin biosynthesis" EXACT [] synonym: "vancomycin formation" EXACT [] synonym: "vancomycin synthesis" EXACT [] is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0033071 ! vancomycin metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0033073 name: pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] synonym: "pinene metabolism" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0033074 name: pinene catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] synonym: "pinene breakdown" EXACT [] synonym: "pinene catabolism" EXACT [] synonym: "pinene degradation" EXACT [] is_a: GO:0033073 ! pinene metabolic process is_a: GO:0043694 ! monoterpene catabolic process [Term] id: GO:0033075 name: isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] synonym: "ipecac alkaloid biosynthesis" RELATED [] synonym: "isoquinoline alkaloid anabolism" EXACT [] synonym: "isoquinoline alkaloid biosynthesis" EXACT [] synonym: "isoquinoline alkaloid formation" EXACT [] synonym: "isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0033076 name: isoquinoline alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] synonym: "ipecac alkaloid metabolism" RELATED [] synonym: "isoquinoline alkaloid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0033077 name: T cell differentiation in thymus namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development in thymus" RELATED [GOC:add] synonym: "thymic T cell differentiation" EXACT [] synonym: "thymocyte cell differentiation" EXACT [] synonym: "thymocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033078 name: extrathymic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "extrathymic T cell development" RELATED [GOC:add] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033079 name: immature T cell proliferation namespace: biological_process def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149] is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0033080 name: immature T cell proliferation in thymus namespace: biological_process def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149] synonym: "thymic T cell proliferation" EXACT [] synonym: "thymocyte cell proliferation" EXACT [] synonym: "thymocyte proliferation" EXACT [] is_a: GO:0033079 ! immature T cell proliferation relationship: part_of GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033081 name: regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development in thymus" RELATED [GOC:add] synonym: "regulation of thymic T cell differentiation" EXACT [] synonym: "regulation of thymocyte cell differentiation" EXACT [] synonym: "regulation of thymocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033077 ! T cell differentiation in thymus relationship: regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033082 name: regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033078 ! extrathymic T cell differentiation relationship: regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033083 name: regulation of immature T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0042129 ! regulation of T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033079 ! immature T cell proliferation relationship: regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033084 name: regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of thymic T cell proliferation" EXACT [] synonym: "regulation of thymocyte cell proliferation" EXACT [] synonym: "regulation of thymocyte proliferation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0033083 ! regulation of immature T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033080 ! immature T cell proliferation in thymus relationship: regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033085 name: negative regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add] synonym: "negative regulation of thymic T cell differentiation" EXACT [] synonym: "negative regulation of thymocyte cell differentiation" EXACT [] synonym: "negative regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045581 ! negative regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033077 ! T cell differentiation in thymus relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033086 name: negative regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033078 ! extrathymic T cell differentiation relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033087 name: negative regulation of immature T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042130 ! negative regulation of T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033079 ! immature T cell proliferation relationship: negatively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033088 name: negative regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "negative regulation of thymic T cell proliferation" EXACT [] synonym: "negative regulation of thymocyte cell proliferation" EXACT [] synonym: "negative regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus is_a: GO:0033087 ! negative regulation of immature T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033089 name: positive regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add] synonym: "positive regulation of thymic T cell differentiation" EXACT [] synonym: "positive regulation of thymocyte cell differentiation" EXACT [] synonym: "positive regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045582 ! positive regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033077 ! T cell differentiation in thymus relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033090 name: positive regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033078 ! extrathymic T cell differentiation relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033091 name: positive regulation of immature T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042102 ! positive regulation of T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033079 ! immature T cell proliferation relationship: positively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033092 name: positive regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "positive regulation of thymic T cell proliferation" EXACT [] synonym: "positive regulation of thymocyte cell proliferation" EXACT [] synonym: "positive regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus is_a: GO:0033091 ! positive regulation of immature T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033080 ! immature T cell proliferation in thymus relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033093 name: Weibel-Palade body namespace: cellular_component def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] xref: Wikipedia:Weibel-Palade_body is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030141 ! secretory granule [Term] id: GO:0033094 name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg] synonym: "PAT activity" RELATED [] synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82] synonym: "putrescine transaminase activity" BROAD [] synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "YgjG" RELATED [EC:2.6.1.82] xref: EC:2.6.1.82 xref: MetaCyc:2.6.1.82-RXN xref: RHEA:24655 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033095 name: aleurone grain namespace: cellular_component def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/] synonym: "aleurone body" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033096 name: amyloplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0033097 name: amyloplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033096 ! amyloplast envelope [Term] id: GO:0033098 name: amyloplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0033097 ! amyloplast membrane [Term] id: GO:0033099 name: attachment organelle namespace: cellular_component def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0033100 name: NuA3 histone acetyltransferase complex namespace: cellular_component def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] is_a: GO:0070775 ! H3 histone acetyltransferase complex [Term] id: GO:0033101 name: cellular bud membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] synonym: "cellular bud plasma membrane" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0033102 name: acidocalcisome membrane namespace: cellular_component def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0020022 ! acidocalcisome [Term] id: GO:0033103 name: protein secretion by the type VI secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. synonym: "protein secretion by the T6SS" EXACT [] synonym: "protein secretion by the type VI protein secretion system" EXACT [] synonym: "type VI protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0033104 name: type VI protein secretion system complex namespace: cellular_component def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] synonym: "T6SS complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0033105 name: chlorosome envelope namespace: cellular_component def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128] comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. synonym: "chlorosome membrane" EXACT [] is_a: GO:0034646 ! organelle-enclosing lipid monolayer relationship: part_of GO:0046858 ! chlorosome [Term] id: GO:0033106 name: cis-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] synonym: "cis Golgi network membrane" EXACT [] synonym: "Golgi cis face membrane" RELATED [] is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005801 ! cis-Golgi network [Term] id: GO:0033107 name: Cvt vesicle namespace: cellular_component def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] synonym: "cytoplasm to vacuole targeting vesicle" EXACT [] synonym: "cytoplasm-to-vacuole targeting vesicle" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033108 name: mitochondrial respiratory chain complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0033110 name: Cvt vesicle membrane namespace: cellular_component def: "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway." [GOC:ecd, PMID:20065092] synonym: "cytoplasm to vacuole targeting vesicle membrane" EXACT [] synonym: "cytoplasm-to-vacuole targeting vesicle membrane" EXACT [] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0033107 ! Cvt vesicle [Term] id: GO:0033111 name: attachment organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane." [GOC:ecd] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098589 ! membrane region relationship: part_of GO:0033099 ! attachment organelle [Term] id: GO:0033112 name: cyanelle envelope namespace: cellular_component def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0033113 name: cyanelle membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033112 ! cyanelle envelope [Term] id: GO:0033114 name: cyanelle thylakoid lumen namespace: cellular_component def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] is_a: GO:0031978 ! plastid thylakoid lumen relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033115 name: cyanelle thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033116 name: endoplasmic reticulum-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730] synonym: "ER-Golgi intermediate compartment membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment [Term] id: GO:0033117 name: esterosome namespace: cellular_component def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033118 name: esterosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0033117 ! esterosome [Term] id: GO:0033119 name: negative regulation of RNA splicing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008380 ! RNA splicing relationship: negatively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033120 name: positive regulation of RNA splicing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051254 ! positive regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008380 ! RNA splicing relationship: positively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033121 name: regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "regulation of purine nucleotide breakdown" EXACT [] synonym: "regulation of purine nucleotide catabolism" EXACT [] synonym: "regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006195 ! purine nucleotide catabolic process relationship: regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033122 name: negative regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "negative regulation of purine nucleotide breakdown" EXACT [] synonym: "negative regulation of purine nucleotide catabolism" EXACT [] synonym: "negative regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030812 ! negative regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006195 ! purine nucleotide catabolic process relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033123 name: positive regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "positive regulation of purine nucleotide breakdown" EXACT [] synonym: "positive regulation of purine nucleotide catabolism" EXACT [] synonym: "positive regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030813 ! positive regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006195 ! purine nucleotide catabolic process relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033124 name: obsolete regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "regulation of GTP breakdown" EXACT [] synonym: "regulation of GTP catabolism" EXACT [] synonym: "regulation of GTP degradation" EXACT [] is_obsolete: true consider: GO:0043087 [Term] id: GO:0033125 name: obsolete negative regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "negative regulation of GTP breakdown" EXACT [] synonym: "negative regulation of GTP catabolism" EXACT [] synonym: "negative regulation of GTP degradation" EXACT [] is_obsolete: true consider: GO:0034260 [Term] id: GO:0033126 name: obsolete positive regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "positive regulation of GTP breakdown" EXACT [] synonym: "positive regulation of GTP catabolism" EXACT [] synonym: "positive regulation of GTP degradation" EXACT [] is_obsolete: true consider: GO:0043547 [Term] id: GO:0033127 name: regulation of histone phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031056 ! regulation of histone modification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016572 ! histone phosphorylation relationship: regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033128 name: negative regulation of histone phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016572 ! histone phosphorylation relationship: negatively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033129 name: positive regulation of histone phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0033127 ! regulation of histone phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016572 ! histone phosphorylation relationship: positively_regulates GO:0016572 ! histone phosphorylation [Term] id: GO:0033130 name: acetylcholine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acetylcholine receptor." [GOC:mah] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0033131 name: regulation of glucokinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "glucokinase regulator" NARROW [] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:1903299 ! regulation of hexokinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004340 ! glucokinase activity relationship: regulates GO:0004340 ! glucokinase activity [Term] id: GO:0033132 name: negative regulation of glucokinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "down regulation of glucokinase activity" EXACT [] synonym: "down-regulation of glucokinase activity" EXACT [] synonym: "downregulation of glucokinase activity" EXACT [] synonym: "glucokinase inhibitor" NARROW [] synonym: "inhibition of glucokinase activity" NARROW [] is_a: GO:0033131 ! regulation of glucokinase activity is_a: GO:1903300 ! negative regulation of hexokinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004340 ! glucokinase activity relationship: negatively_regulates GO:0004340 ! glucokinase activity [Term] id: GO:0033133 name: positive regulation of glucokinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] synonym: "glucokinase activator" NARROW [] synonym: "stimulation of glucokinase activity" NARROW [] synonym: "up regulation of glucokinase activity" EXACT [] synonym: "up-regulation of glucokinase activity" EXACT [] synonym: "upregulation of glucokinase activity" EXACT [] is_a: GO:0033131 ! regulation of glucokinase activity is_a: GO:1903301 ! positive regulation of hexokinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004340 ! glucokinase activity relationship: positively_regulates GO:0004340 ! glucokinase activity [Term] id: GO:0033134 name: ubiquitin activating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah] is_a: GO:0044388 ! small protein activating enzyme binding [Term] id: GO:0033135 name: regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018105 ! peptidyl-serine phosphorylation relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033137 name: negative regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033138 name: positive regulation of peptidyl-serine phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation [Term] id: GO:0033139 name: regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process alt_id: GO:1903261 def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] synonym: "regulation of serine phosphorylation of STAT3 protein" NARROW [] is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042501 ! serine phosphorylation of STAT protein relationship: regulates GO:0042501 ! serine phosphorylation of STAT protein created_by: mr creation_date: 2014-08-06T21:22:57Z [Term] id: GO:0033140 name: negative regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process alt_id: GO:1903262 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] synonym: "down regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "down-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "downregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "inhibition of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "negative regulation of serine phosphorylation of STAT3 protein" NARROW [] is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein relationship: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein [Term] id: GO:0033141 name: positive regulation of peptidyl-serine phosphorylation of STAT protein namespace: biological_process alt_id: GO:1903263 def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] synonym: "activation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "positive regulation of serine phosphorylation of STAT3 protein" NARROW [] synonym: "up regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "up-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] synonym: "upregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein relationship: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein [Term] id: GO:0033142 name: progesterone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a progesterone receptor." [GOC:mah] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0033143 name: regulation of intracellular steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] synonym: "regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] synonym: "regulation of steroid hormone receptor signalling pathway" BROAD [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway relationship: regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0033144 name: negative regulation of intracellular steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] synonym: "negative regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] synonym: "negative regulation of steroid hormone receptor signalling pathway" BROAD [GOC:bf] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway relationship: negatively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0033145 name: positive regulation of intracellular steroid hormone receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] synonym: "positive regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] synonym: "positive regulation of steroid hormone receptor signalling pathway" BROAD [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway relationship: positively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0033146 name: regulation of intracellular estrogen receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] synonym: "regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] synonym: "regulation of estrogen receptor signalling pathway" EXACT [] is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030520 ! intracellular estrogen receptor signaling pathway relationship: regulates GO:0030520 ! intracellular estrogen receptor signaling pathway [Term] id: GO:0033147 name: negative regulation of intracellular estrogen receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] synonym: "negative regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] synonym: "negative regulation of estrogen receptor signalling pathway" EXACT [] is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway relationship: negatively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway [Term] id: GO:0033148 name: positive regulation of intracellular estrogen receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] synonym: "positive regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] synonym: "positive regulation of estrogen receptor signalling pathway" BROAD [] is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway relationship: positively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway [Term] id: GO:0033149 name: FFAT motif binding namespace: molecular_function def: "Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0033150 name: cytoskeletal calyx namespace: cellular_component def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0033011 ! perinuclear theca [Term] id: GO:0033151 name: V(D)J recombination namespace: biological_process def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149] synonym: "V(D)J joining" EXACT [] synonym: "V-D-J joining" EXACT [] synonym: "V-D-J recombination" EXACT [] synonym: "V-J joining" EXACT [] synonym: "V-J recombination" EXACT [] xref: Wikipedia:V(D)J_recombination is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus [Term] id: GO:0033152 name: immunoglobulin V(D)J recombination namespace: biological_process def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add] synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add] synonym: "immunoglobulin V-J joining" NARROW [GOC:add] synonym: "immunoglobulin V-J recombination" NARROW [GOC:add] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033153 name: T cell receptor V(D)J recombination namespace: biological_process def: "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221] synonym: "T cell receptor V(D)J joining" EXACT [GOC:add] synonym: "T cell receptor V-D-J joining" NARROW [GOC:add] synonym: "T cell receptor V-D-J recombination" NARROW [GOC:add] synonym: "T cell receptor V-J joining" NARROW [GOC:add] synonym: "T cell receptor V-J recombination" NARROW [GOC:add] synonym: "T-cell receptor V(D)J recombination" EXACT [GOC:add] synonym: "TCR V(D)J recombination" EXACT [GOC:add] is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments is_a: GO:0033151 ! V(D)J recombination [Term] id: GO:0033154 name: ATPase-coupled oligogalacturonide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg] synonym: "ATP-dependent oligogalacturonide transmembrane transporter activity" EXACT [] synonym: "oligogalacturonide transporting ATPase activity" RELATED [] synonym: "oligogalacturonide-transporting ATPase activity" EXACT [] is_a: GO:0015422 ! ATPase-coupled oligosaccharide transmembrane transporter activity is_a: GO:0033155 ! oligogalacturonide transmembrane transporter activity [Term] id: GO:0033155 name: oligogalacturonide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oligogalacturonide from one side of a membrane to the other." [GOC:mlg] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity relationship: part_of GO:0033156 ! oligogalacturonide transport [Term] id: GO:0033156 name: oligogalacturonide transport namespace: biological_process def: "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006886 ! intracellular protein transport relationship: regulates GO:0006886 ! intracellular protein transport [Term] id: GO:0033158 name: obsolete regulation of protein import into nucleus, translocation namespace: biological_process def: "OBSOLETE. Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "regulation of protein import into cell nucleus, translocation" EXACT [] is_obsolete: true [Term] id: GO:0033159 name: obsolete negative regulation of protein import into nucleus, translocation namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT [] is_obsolete: true [Term] id: GO:0033160 name: obsolete positive regulation of protein import into nucleus, translocation namespace: biological_process def: "OBSOLETE. Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT [] is_obsolete: true [Term] id: GO:0033161 name: mitogen-activated protein kinase kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah] synonym: "MAPKKKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0033162 name: melanosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a melanosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0090741 ! pigment granule membrane is_a: GO:0098805 ! whole membrane relationship: part_of GO:0042470 ! melanosome relationship: part_of GO:0045009 ! chitosome [Term] id: GO:0033163 name: microneme membrane namespace: cellular_component def: "The lipid bilayer surrounding a microneme." [GOC:mah] is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0020009 ! microneme [Term] id: GO:0033164 name: glycolipid 6-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994] synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232] xref: EC:2.4.1.232 xref: MetaCyc:2.4.1.232-RXN is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0033165 name: interphotoreceptor matrix namespace: cellular_component def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0033166 name: hyaline layer namespace: cellular_component def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0033167 name: ARC complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250] synonym: "argonaute siRNA chaperone complex" EXACT [] is_a: GO:0031332 ! RNAi effector complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033168 name: conversion of ds siRNA to ss siRNA involved in RNA interference namespace: biological_process def: "The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250] synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah] is_a: GO:0036404 ! conversion of ds siRNA to ss siRNA intersection_of: GO:0036404 ! conversion of ds siRNA to ss siRNA intersection_of: part_of GO:0016246 ! RNA interference relationship: part_of GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0033169 name: histone H3-K9 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0033170 name: protein-DNA loading ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw] synonym: "DNA-protein loading ATPase activity" EXACT [GOC:mah] is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0033171 name: obsolete nucleoprotein filament-forming ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw] comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading. synonym: "nucleoprotein filament-forming ATPase activity" EXACT [] is_obsolete: true [Term] id: GO:0033172 name: gas vesicle shell namespace: cellular_component def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd] synonym: "gas vesicle membrane" RELATED [] synonym: "gas vesicle wall" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031411 ! gas vesicle [Term] id: GO:0033173 name: calcineurin-NFAT signaling cascade namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf] synonym: "calcineurin-NFAT signalling pathway" RELATED [] is_a: GO:0048016 ! inositol phosphate-mediated signaling is_a: GO:0097720 ! calcineurin-mediated signaling [Term] id: GO:0033174 name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839] synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT [] is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex [Term] id: GO:0033175 name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) namespace: cellular_component def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah] synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT [] is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex [Term] id: GO:0033176 name: proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "hydrogen-translocating V-type ATPase complex" EXACT [] is_a: GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033177 name: proton-transporting two-sector ATPase complex, proton-transporting domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033178 name: proton-transporting two-sector ATPase complex, catalytic domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex [Term] id: GO:0033179 name: proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex [Term] id: GO:0033180 name: proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex [Term] id: GO:0033181 name: plasma membrane proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT [] is_a: GO:0033176 ! proton-transporting V-type ATPase complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0033182 name: regulation of histone ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031396 ! regulation of protein ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016574 ! histone ubiquitination relationship: regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033183 name: negative regulation of histone ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:0033182 ! regulation of histone ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016574 ! histone ubiquitination relationship: negatively_regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033184 name: positive regulation of histone ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:0033182 ! regulation of histone ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016574 ! histone ubiquitination relationship: positively_regulates GO:0016574 ! histone ubiquitination [Term] id: GO:0033185 name: dolichol-phosphate-mannose synthase complex namespace: cellular_component def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346] synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT [] synonym: "DPM synthase complex" EXACT [] is_a: GO:0031501 ! mannosyltransferase complex [Term] id: GO:0033186 name: CAF-1 complex namespace: cellular_component def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] comment: In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90. synonym: "chromatin assembly factor 1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0033187 name: obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "inositol hexakisphosphate 4-kinase or 6-kinase activity" EXACT [] is_obsolete: true consider: GO:0000830 consider: GO:0000831 [Term] id: GO:0033188 name: sphingomyelin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin." [EC:2.7.8.27, RHEA:18765] synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27] synonym: "SM synthase activity" EXACT [EC:2.7.8.27] synonym: "SMS1" RELATED [EC:2.7.8.27] synonym: "SMS2" RELATED [EC:2.7.8.27] xref: EC:2.7.8.27 xref: KEGG_REACTION:R08969 xref: MetaCyc:2.7.8.27-RXN xref: Reactome:R-HSA-429786 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]" xref: Reactome:R-HSA-429798 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]" xref: RHEA:18765 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0033189 name: response to vitamin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl] synonym: "response to retinol" NARROW [] is_a: GO:0033273 ! response to vitamin is_a: GO:0033993 ! response to lipid [Term] id: GO:0033190 name: solanapyrone synthase activity namespace: molecular_function def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0033191 name: macrophomate synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [GOC:cb, PMID:10984474] is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0033192 name: calmodulin-dependent protein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED [] synonym: "calcineurin activity" NARROW [] synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT [] xref: Reactome:R-HSA-2730849 "Calcineurin binds and dephosphorylates NFAT" xref: Reactome:R-HSA-4551451 "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling" is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity [Term] id: GO:0033193 name: Lsd1/2 complex namespace: cellular_component def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621] synonym: "SAPHIRE complex" EXACT [PMID:17371846] synonym: "Swm complex" EXACT [PMID:17440621] synonym: "Swm1/2 complex" RELATED [PMID:17440621] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0033194 name: response to hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0033195 name: response to alkyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0033196 name: tryparedoxin peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O." [GOC:mah] synonym: "TXNPx activity" EXACT [] xref: MetaCyc:1.11.1.15-RXN is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0033197 name: response to vitamin E namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl] synonym: "response to DL-alpha-tocopherol acetate" NARROW [] synonym: "response to DL-alpha-tocopheryl acetate" NARROW [] synonym: "response to O-Acetyl-alpha-tocopherol" NARROW [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0033198 name: response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] synonym: "response to adenosine 5'-triphosphate" EXACT [] synonym: "response to adenosine triphosphate" EXACT [] is_a: GO:0007584 ! response to nutrient is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0042493 ! response to drug is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0033199 name: obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "inositol heptakisphosphate 4-kinase or 6-kinase activity" EXACT [] is_obsolete: true consider: GO:0000833 consider: GO:0000834 [Term] id: GO:0033200 name: inositol heptakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT [] synonym: "IP7 5-kinase activity" EXACT [] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0033201 name: alpha-1,4-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966] synonym: "1,4-alpha-glucan synthase activity" EXACT [] xref: EC:2.4.1.21 xref: RHEA:18189 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0033202 name: DNA helicase complex namespace: cellular_component def: "A protein complex that possesses DNA helicase activity." [GOC:mah] subset: goslim_metagenomics subset: goslim_pir is_a: GO:1904949 ! ATPase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0033203 name: DNA helicase A complex namespace: cellular_component def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218] is_a: GO:0033202 ! DNA helicase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033204 name: ribonuclease P RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963] synonym: "RNase P RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0033206 name: meiotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0033207 name: beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah] synonym: "beta-1,4-GalNAc transferase activity" EXACT [] is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0033208 name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623] synonym: "Sda beta 1,4GalNAc transferase" RELATED [] synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity [Term] id: GO:0033209 name: tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "TNF-alpha-mediated signaling pathway" NARROW [] synonym: "tumor necrosis factor alpha-mediated signaling pathway" NARROW [] synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071356 ! cellular response to tumor necrosis factor [Term] id: GO:0033210 name: leptin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body." [GOC:mah, GOC:signaling, GOC:yaf] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0044320 ! cellular response to leptin stimulus [Term] id: GO:0033211 name: adiponectin-activated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:20536390] synonym: "adipocytokine signaling pathway" RELATED [] synonym: "adiponectin-mediated signaling pathway" RELATED [] synonym: "adiponectin-mediated signalling pathway" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0033212 name: iron import into cell namespace: biological_process alt_id: GO:0070627 def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism] synonym: "ferrous ion import" NARROW [] synonym: "ferrous iron import" NARROW [] synonym: "ferrous iron uptake" NARROW [] synonym: "iron assimilation" RELATED [] is_a: GO:0006826 ! iron ion transport is_a: GO:0006879 ! cellular iron ion homeostasis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0098657 ! import into cell created_by: midori creation_date: 2009-05-01T04:19:14Z [Term] id: GO:0033214 name: siderophore-dependent iron import into cell namespace: biological_process alt_id: GO:0015688 alt_id: GO:0033213 def: "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626] synonym: "iron assimilation by capture and transport" RELATED [] synonym: "iron assimilation by chelation and transport" EXACT [] synonym: "iron chelate transport" BROAD [] is_a: GO:0033212 ! iron import into cell is_a: GO:1901678 ! iron coordination entity transport relationship: has_part GO:0098711 ! iron ion import across plasma membrane [Term] id: GO:0033215 name: reductive iron assimilation namespace: biological_process def: "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:cjm, GOC:mah, PMID:16963626] synonym: "iron assimilation by reduction and transport" EXACT [] is_a: GO:0033212 ! iron import into cell relationship: has_part GO:0000293 ! ferric-chelate reductase activity relationship: has_part GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0033217 name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [] is_a: GO:0010106 ! cellular response to iron ion starvation is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0033218 name: amide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0033219 name: urea binding namespace: molecular_function def: "Interacting selectively and non-covalently with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [GOC:mah, ISBN:0198506732] is_a: GO:0033218 ! amide binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0033220 name: ATPase-coupled amide-transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah] synonym: "amide-transporting ATPase activity" EXACT [] synonym: "ATP-dependent amide-transporter activity" EXACT [] is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0033221 name: ATPase-coupled urea transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg] synonym: "ATP-dependent urea transmembrane transporter activity" EXACT [] synonym: "carbamide-transporting ATPase activity" EXACT [] synonym: "urea-transporting ATPase activity" EXACT [] xref: RHEA:32803 is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0033220 ! ATPase-coupled amide-transporter activity [Term] id: GO:0033222 name: xylose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of xylose." [GOC:mah] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0033223 name: 2-aminoethylphosphonate transport namespace: biological_process def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "2-phosphonoethylamine transport" EXACT [] synonym: "ciliatine transport" EXACT [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0033224 name: 2-aminoethylphosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other." [GOC:mlg] synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT [] synonym: "ciliatine transporter activity" EXACT [] is_a: GO:0022804 ! active transmembrane transporter activity relationship: part_of GO:0033223 ! 2-aminoethylphosphonate transport [Term] id: GO:0033225 name: ATPase-coupled 2-aminoethylphosphonate transporter activity namespace: molecular_function def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg] synonym: "2-aminoethylphosphonate transporting ATPase activity" RELATED [] synonym: "2-aminoethylphosphonate-transporting ATPase activity" EXACT [] synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT [] synonym: "ATP-dependent 2-aminoethylphosphonate transporter activity" EXACT [] synonym: "ciliatine transportingATPase activity" EXACT [] xref: RHEA:32775 is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0033226 name: 2-aminoethylphosphonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg] synonym: "2-phosphonoethylamine binding" EXACT [] synonym: "ciliatine binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0033227 name: dsRNA transport namespace: biological_process def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0050658 ! RNA transport [Term] id: GO:0033228 name: cysteine export across plasma membrane namespace: biological_process def: "The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mlg] synonym: "cysteine export" BROAD [] is_a: GO:0032973 ! amino acid export across plasma membrane is_a: GO:1903712 ! cysteine transmembrane transport [Term] id: GO:0033229 name: cysteine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cysteine from one side of a membrane to the other." [GOC:mah] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:1903712 ! cysteine transmembrane transport [Term] id: GO:0033230 name: ATPase-coupled cysteine transmembrane transporter activity namespace: molecular_function alt_id: GO:0032519 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg] synonym: "ATP-dependent cysteine transporter activity" EXACT [] synonym: "ATPase-coupled cysteine transporter activity" RELATED [] synonym: "cysteine exporter" RELATED [] synonym: "cysteine-exporting ATPase activity" RELATED [] synonym: "cysteine-transporting ATPase activity" EXACT [] xref: RHEA:32795 is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity is_a: GO:0033229 ! cysteine transmembrane transporter activity [Term] id: GO:0033231 name: carbohydrate export namespace: biological_process def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0033232 name: ATPase-coupled D-methionine transporter activity namespace: molecular_function alt_id: GO:0032521 alt_id: GO:0032522 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg, PMID:18621668] synonym: "ATP-dependent D-methionine transporter activity" EXACT [] synonym: "D-methionine exporter" RELATED [] synonym: "D-methionine importer" RELATED [] synonym: "D-methionine-exporting ATPase activity" RELATED [] synonym: "D-methionine-importing ATPase activity" RELATED [] synonym: "D-methionine-transporting ATPase activity" EXACT [] is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0033233 name: regulation of protein sumoylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "regulation of sumoylation" EXACT [] is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016925 ! protein sumoylation relationship: regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033234 name: negative regulation of protein sumoylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "negative regulation of sumoylation" EXACT [] is_a: GO:0033233 ! regulation of protein sumoylation is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016925 ! protein sumoylation relationship: negatively_regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033235 name: positive regulation of protein sumoylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] synonym: "positive regulation of sumoylation" EXACT [] is_a: GO:0033233 ! regulation of protein sumoylation is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016925 ! protein sumoylation relationship: positively_regulates GO:0016925 ! protein sumoylation [Term] id: GO:0033236 name: obsolete 11-beta-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] synonym: "11-beta-hydroxysteroid dehydrogenase (NAD+) activity" EXACT [] is_obsolete: true replaced_by: GO:0070523 [Term] id: GO:0033237 name: obsolete 11-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT [] synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] xref: EC:1.1.1.146 xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_obsolete: true replaced_by: GO:0070524 [Term] id: GO:0033238 name: regulation of cellular amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] synonym: "regulation of amine metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044106 ! cellular amine metabolic process relationship: regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033239 name: negative regulation of cellular amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044106 ! cellular amine metabolic process relationship: negatively_regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033240 name: positive regulation of cellular amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044106 ! cellular amine metabolic process relationship: positively_regulates GO:0044106 ! cellular amine metabolic process [Term] id: GO:0033241 name: regulation of cellular amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009310 ! amine catabolic process relationship: regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033242 name: negative regulation of cellular amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0033241 ! regulation of cellular amine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009310 ! amine catabolic process relationship: negatively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033243 name: positive regulation of cellular amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0033241 ! regulation of cellular amine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009310 ! amine catabolic process relationship: positively_regulates GO:0009310 ! amine catabolic process [Term] id: GO:0033244 name: regulation of penicillin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "regulation of penicillin metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042316 ! penicillin metabolic process relationship: regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033245 name: negative regulation of penicillin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "negative regulation of penicillin metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042316 ! penicillin metabolic process relationship: negatively_regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033246 name: positive regulation of penicillin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "positive regulation of penicillin metabolism" EXACT [] is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042316 ! penicillin metabolic process relationship: positively_regulates GO:0042316 ! penicillin metabolic process [Term] id: GO:0033247 name: regulation of penicillin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "regulation of penicillin breakdown" EXACT [] synonym: "regulation of penicillin catabolism" EXACT [] synonym: "regulation of penicillin degradation" EXACT [] is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042317 ! penicillin catabolic process relationship: regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033248 name: negative regulation of penicillin catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "negative regulation of penicillin breakdown" EXACT [] synonym: "negative regulation of penicillin catabolism" EXACT [] synonym: "negative regulation of penicillin degradation" EXACT [] is_a: GO:0033245 ! negative regulation of penicillin metabolic process is_a: GO:0033247 ! regulation of penicillin catabolic process is_a: GO:0034252 ! negative regulation of cellular amide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042317 ! penicillin catabolic process relationship: negatively_regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033249 name: positive regulation of penicillin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] synonym: "positive regulation of penicillin breakdown" EXACT [] synonym: "positive regulation of penicillin catabolism" EXACT [] synonym: "positive regulation of penicillin degradation" EXACT [] is_a: GO:0033246 ! positive regulation of penicillin metabolic process is_a: GO:0033247 ! regulation of penicillin catabolic process is_a: GO:0034253 ! positive regulation of cellular amide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042317 ! penicillin catabolic process relationship: positively_regulates GO:0042317 ! penicillin catabolic process [Term] id: GO:0033250 name: penicillinase activity namespace: molecular_function def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg] xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0008800 ! beta-lactamase activity [Term] id: GO:0033251 name: cephalosporinase activity namespace: molecular_function def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg] xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0008800 ! beta-lactamase activity [Term] id: GO:0033252 name: regulation of beta-lactamase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008800 ! beta-lactamase activity relationship: regulates GO:0008800 ! beta-lactamase activity [Term] id: GO:0033253 name: regulation of penicillinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah] is_a: GO:0033252 ! regulation of beta-lactamase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033250 ! penicillinase activity relationship: regulates GO:0033250 ! penicillinase activity [Term] id: GO:0033254 name: vacuolar transporter chaperone complex namespace: cellular_component def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729] synonym: "VTC complex" EXACT [] is_a: GO:0101031 ! chaperone complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0033255 name: SAS acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653] synonym: "SAS-I complex" EXACT [] is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex [Term] id: GO:0033256 name: I-kappaB/NF-kappaB complex namespace: cellular_component def: "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0033257 name: Bcl3/NF-kappaB2 complex namespace: cellular_component def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] synonym: "Bcl3-NFKB2 complex" RELATED [] synonym: "Bcl3-p52 complex" EXACT [] is_a: GO:0033256 ! I-kappaB/NF-kappaB complex [Term] id: GO:0033258 name: plastid DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah] synonym: "plastid DNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0033259 name: plastid DNA replication namespace: biological_process def: "The process in which new strands of DNA are synthesized in a plastid." [GOC:mah] synonym: "plastid DNA synthesis" RELATED [] synonym: "replication of plastid DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0033258 ! plastid DNA metabolic process intersection_of: GO:0006261 ! DNA-dependent DNA replication intersection_of: occurs_in GO:0009536 ! plastid relationship: occurs_in GO:0009536 ! plastid [Term] id: GO:0033260 name: nuclear DNA replication namespace: biological_process def: "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "DNA replication involved in S phase" EXACT [] synonym: "DNA replication involved in S-phase" EXACT [] synonym: "nuclear cell cycle DNA replication" EXACT [] is_a: GO:0044786 ! cell cycle DNA replication intersection_of: GO:0006260 ! DNA replication intersection_of: occurs_in GO:0005634 ! nucleus intersection_of: part_of GO:0007049 ! cell cycle relationship: occurs_in GO:0005634 ! nucleus [Term] id: GO:0033261 name: obsolete regulation of S phase namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because cell cycle phases are intervals and so cannot be regulated as such, rather it is the transitions between the phases that are regulated. This term was often also used to annotate genes which should have been annotated to 'regulation of DNA replication', or one of its children. synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb] synonym: "regulation of S phase" EXACT [] synonym: "regulation of S-phase" EXACT [] xref: MetaCyc:PWY-5043 xref: MetaCyc:SALVADEHYPOX-PWY xref: MetaCyc:SALVPURINE2-PWY is_obsolete: true consider: GO:0044770 [Term] id: GO:0033262 name: regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "regulation of DNA replication involved in S phase" EXACT [] synonym: "regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033260 ! nuclear DNA replication relationship: regulates GO:0033260 ! nuclear DNA replication [Term] id: GO:0033263 name: CORVET complex namespace: cellular_component def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005768 ! endosome [Term] id: GO:0033264 name: obsolete bontoxilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69] comment: This term was made obsolete because it represents a gene product. synonym: "BoNT" RELATED [EC:3.4.24.69] synonym: "bontoxilysin activity" EXACT [] synonym: "botulinum neurotoxin activity" EXACT [] xref: EC:3.4.24.69 xref: MetaCyc:3.4.24.69-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0033265 name: choline binding namespace: molecular_function def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [GOC:mlg] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0033266 name: ATPase-coupled choline transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane." [GOC:mlg] synonym: "ATP-dependent choline transmembrane transporter activity" EXACT [] synonym: "choline-transporting ATPase activity" EXACT [] is_a: GO:0015220 ! choline transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0033267 name: obsolete axon part namespace: cellular_component def: "OBSOLETE. A part of an axon, a cell projection of a neuron." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: NIF_Subcellular:sao280355188 is_obsolete: true consider: GO:0030424 [Term] id: GO:0033268 name: node of Ranvier namespace: cellular_component def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh] synonym: "node of Ranvier axon" RELATED [NIF_Subcellular:sao188049490] xref: NIF_Subcellular:birnlex_1152_2 xref: Wikipedia:Nodes_of_Ranvier is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033269 name: internode region of axon namespace: cellular_component def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh] synonym: "internode" EXACT [] xref: NIF_Subcellular:sao206157942 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033270 name: paranode region of axon namespace: cellular_component def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858] synonym: "paranode" EXACT [] xref: NIF_Subcellular:sao234066064 xref: NIF_Subcellular:sao936144858 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon [Term] id: GO:0033271 name: myo-inositol phosphate transport namespace: biological_process def: "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0033272 name: myo-inositol hexakisphosphate transport namespace: biological_process def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "phytate transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0033271 ! myo-inositol phosphate transport [Term] id: GO:0033273 name: response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] is_a: GO:0007584 ! response to nutrient [Term] id: GO:0033274 name: response to vitamin B2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl] synonym: "response to riboflavin" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug [Term] id: GO:0033275 name: actin-myosin filament sliding namespace: biological_process def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf] synonym: "actin filament sliding" RELATED [] is_a: GO:0070252 ! actin-mediated cell contraction [Term] id: GO:0033276 name: transcription factor TFTC complex namespace: cellular_component def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525] is_a: GO:0070461 ! SAGA-type complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0033277 name: abortive mitotic cell cycle namespace: biological_process def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008] comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms. synonym: "abortive mitosis" RELATED [] is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0033278 name: cell proliferation in midbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] comment: This term was added by GO_REF:0000021. synonym: "cell proliferation in mesencephalon" EXACT [] synonym: "mesencepahalic cell proliferation" RELATED [] is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0033280 name: response to vitamin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl] synonym: "response to calciferol" EXACT [] synonym: "response to cholecalciferol" NARROW [] synonym: "response to ergocalciferol" NARROW [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0033281 name: TAT protein transport complex namespace: cellular_component def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators] synonym: "TAT protein secretion complex" NARROW [] synonym: "TAT protein translocation system complex" NARROW [] synonym: "Twin-arginine translocation complex" NARROW [] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0033282 name: protein C inhibitor-acrosin complex namespace: cellular_component def: "A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin." [GOC:pr, PMID:11120760, PMID:7521127] synonym: "PCI-ACR complex" EXACT [PR:000003652, PR:000014685] synonym: "PCI-acrosin complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-acrosin complex" EXACT [PR:000014685] synonym: "serpin A5-acrosin complex" EXACT [PR:000014685] synonym: "SERPINA5-acrosin complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0033283 name: ATPase-coupled organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg] synonym: "ATP-dependent organic acid transmembrane transporter activity" EXACT [] synonym: "organic acid-transporting ATPase activity" EXACT [] is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0033284 name: ATPase-coupled carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg] synonym: "ATP-dependent carboxylic acid transporter activity" EXACT [] synonym: "carboxylic acid-transporting ATPase activity" EXACT [] is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0033285 name: ATPase-coupled monocarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg] synonym: "ATP-dependent monocarboxylic acid transmembrane transporter activity" EXACT [] synonym: "monocarboxylic acid-transporting ATPase activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity [Term] id: GO:0033286 name: ATPase-coupled ectoine transmembrane transporter activity namespace: molecular_function alt_id: GO:0051471 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg] synonym: "ATP-dependent ectoine transmembrane transporter activity" EXACT [] synonym: "ectoine transmembrane transporter activity" BROAD [] synonym: "ectoine-transporting ATPase activity" EXACT [] xref: RHEA:32787 xref: RHEA:32791 is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0051470 ! ectoine transport [Term] id: GO:0033288 name: ATPase-coupled hydroxyectoine transmembrane transporter activity namespace: molecular_function alt_id: GO:0033287 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg] synonym: "ATP-dependent hydroxyectoine transmembrane transporter activity" EXACT [] synonym: "hydroxyectoine transmembrane transporter activity" BROAD [] synonym: "hydroxyectoine-transporting ATPase activity" EXACT [] is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0033308 ! hydroxyectoine transport [Term] id: GO:0033289 name: intraconoid microtubule namespace: cellular_component def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471] is_a: GO:0005874 ! microtubule relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0033290 name: eukaryotic 48S preinitiation complex namespace: cellular_component alt_id: GO:0016283 def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 48S initiation complex" RELATED [] synonym: "eukaryotic 48S pre-initiation complex" EXACT [] is_a: GO:0070993 ! translation preinitiation complex relationship: has_part GO:0022627 ! cytosolic small ribosomal subunit [Term] id: GO:0033291 name: eukaryotic 80S initiation complex namespace: cellular_component def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049] is_a: GO:0070992 ! translation initiation complex [Term] id: GO:0033292 name: T-tubule organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah] synonym: "T-tubule organisation" EXACT [GOC:mah] synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah] synonym: "transverse tubule organization" EXACT [GOC:rl] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0007009 ! plasma membrane organization relationship: part_of GO:0055001 ! muscle cell development [Term] id: GO:0033293 name: monocarboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0033294 name: ectoine binding namespace: molecular_function def: "Interacting selectively and non-covalently with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0033295 name: hydroxyectoine binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroxyectoine." [GOC:mlg] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0043178 ! alcohol binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0033296 name: rhamnose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of rhamnose." [GOC:mah] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0033297 name: ATPase-coupled rhamnose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg] synonym: "ATP-dependent rhamnose transmembrane transporter activity" EXACT [] synonym: "rhamnose-transporting ATPase activity" EXACT [] is_a: GO:0015153 ! rhamnose transmembrane transporter activity is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity [Term] id: GO:0033298 name: contractile vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah] synonym: "contractile vacuole organisation" EXACT [GOC:mah] synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007033 ! vacuole organization is_a: GO:0016050 ! vesicle organization [Term] id: GO:0033299 name: secretion of lysosomal enzymes namespace: biological_process def: "The controlled release of lysosomal enzymes by a cell." [GOC:mah] is_a: GO:0009306 ! protein secretion [Term] id: GO:0033300 name: dehydroascorbic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other." [GOC:go_curators] synonym: "dehydroascorbate transporter activity" EXACT [] synonym: "dehydroascorbic acid transporter activity" RELATED [] xref: Reactome:R-HSA-198818 "GLUT1/3 transports extracellular DHvitC to cytosol" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0070837 ! dehydroascorbic acid transport [Term] id: GO:0033301 name: cell cycle comprising mitosis without cytokinesis namespace: biological_process def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah] comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0033302 name: quercetin O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] synonym: "quercetin O-glucoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051552 ! flavone metabolic process [Term] id: GO:0033303 name: quercetin O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] synonym: "quercetin O-glucoside anabolism" EXACT [] synonym: "quercetin O-glucoside biosynthesis" EXACT [] synonym: "quercetin O-glucoside formation" EXACT [] synonym: "quercetin O-glucoside synthesit" EXACT [] xref: MetaCyc:PWY-5321 is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0033302 ! quercetin O-glucoside metabolic process is_a: GO:0051553 ! flavone biosynthetic process [Term] id: GO:0033304 name: chlorophyll a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyll a." [GOC:mah] synonym: "chlorophyll a metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0033305 name: chlorophyll a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [GOC:mah] synonym: "chlorophyll a anabolism" EXACT [] synonym: "chlorophyll a biosynthesis" EXACT [] synonym: "chlorophyll a formation" EXACT [] synonym: "chlorophyll a synthesis" EXACT [] is_a: GO:0015995 ! chlorophyll biosynthetic process is_a: GO:0033304 ! chlorophyll a metabolic process [Term] id: GO:0033306 name: phytol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah] synonym: "phytol metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1903173 ! fatty alcohol metabolic process [Term] id: GO:0033307 name: phytol salvage namespace: biological_process def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107] synonym: "phytol salvage pathway" EXACT [] xref: MetaCyc:PWY-5107 is_a: GO:0033520 ! phytol biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0033308 name: hydroxyectoine transport namespace: biological_process def: "The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0033309 name: SBF transcription complex namespace: cellular_component def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:19150335, PMID:7917338] synonym: "SBF complex" EXACT [GOC:mah] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0033310 name: chlorophyll a catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [GOC:mah] synonym: "chlorophyll a breakdown" EXACT [] synonym: "chlorophyll a catabolism" EXACT [] synonym: "chlorophyll a degradation" EXACT [] xref: MetaCyc:PWY-5086 xref: MetaCyc:PWY-5098 is_a: GO:0015996 ! chlorophyll catabolic process is_a: GO:0033304 ! chlorophyll a metabolic process [Term] id: GO:0033311 name: chlorophyll a biosynthetic process via phytyl diphosphate namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [GOC:mah, MetaCyc:PWY-5086] synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT [] synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT [] synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT [] synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT [] synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT [] xref: MetaCyc:PWY-5086 is_a: GO:0033305 ! chlorophyll a biosynthetic process [Term] id: GO:0033312 name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a namespace: biological_process def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [GOC:mah, MetaCyc:PWY-5064] synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT [] synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT [] xref: MetaCyc:PWY-5064 is_a: GO:0033305 ! chlorophyll a biosynthetic process [Term] id: GO:0033313 name: meiotic cell cycle checkpoint namespace: biological_process def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000075 ! cell cycle checkpoint intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0033314 name: mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0031574 def: "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle DNA replication checkpoint" EXACT [] synonym: "S-M checkpoint" EXACT [] synonym: "S-M DNA replication checkpoint" EXACT [] synonym: "S-phase checkpoint" BROAD [] is_a: GO:0000076 ! DNA replication checkpoint is_a: GO:0044774 ! mitotic DNA integrity checkpoint is_a: GO:0044818 ! mitotic G2/M transition checkpoint intersection_of: GO:0000076 ! DNA replication checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0033315 name: meiotic G2/MI DNA replication checkpoint namespace: biological_process def: "A DNA integrity checkpoint that acts to inhibit the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete." [GOC:mtg_cell_cycle] synonym: "meiotic cell cycle DNA replication checkpoint" EXACT [] is_a: GO:0000076 ! DNA replication checkpoint is_a: GO:0044778 ! meiotic DNA integrity checkpoint is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition intersection_of: GO:0000076 ! DNA replication checkpoint intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0110031 ! negative regulation of G2/MI transition of meiotic cell cycle [Term] id: GO:0033316 name: meiotic spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] is_a: GO:0044779 ! meiotic spindle checkpoint is_a: GO:0071173 ! spindle assembly checkpoint intersection_of: GO:0071173 ! spindle assembly checkpoint intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0033319 name: UDP-D-xylose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-xylose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033320 name: UDP-D-xylose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821] synonym: "UDP-D-xylose anabolism" EXACT [] synonym: "UDP-D-xylose biosynthesis" EXACT [] synonym: "UDP-D-xylose formation" EXACT [] synonym: "UDP-D-xylose synthesis" EXACT [] xref: MetaCyc:PWY-4821 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033319 ! UDP-D-xylose metabolic process [Term] id: GO:0033321 name: homomethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonym: "homomethionine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0033322 name: homomethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] synonym: "homomethionine anabolism" EXACT [] synonym: "homomethionine biosynthesis" EXACT [] synonym: "homomethionine formation" EXACT [] synonym: "homomethionine synthesis" EXACT [] xref: MetaCyc:PWY-1186 is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0033321 ! homomethionine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0033323 name: choline biosynthetic process via CDP-choline namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561] synonym: "choline anabolism via CDP-choline" EXACT [] synonym: "choline biosynthesis via CDP-choline" EXACT [] synonym: "choline formation via CDP-choline" EXACT [] synonym: "choline synthesis via CDP-choline" EXACT [] xref: MetaCyc:PWY-3561 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033324 name: choline biosynthetic process via N-monomethylethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542] synonym: "choline anabolism via N-monomethylethanolamine" EXACT [] synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT [] synonym: "choline formation via N-monomethylethanolamine" EXACT [] synonym: "choline synthesis via N-monomethylethanolamine" EXACT [] xref: MetaCyc:PWY-3542 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033325 name: choline biosynthetic process via phosphoryl-ethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385] synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT [] synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT [] synonym: "choline formation via phosphoryl-ethanolamine" EXACT [] synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT [] xref: MetaCyc:PWY-3385 xref: MetaCyc:PWY-4762 is_a: GO:0042425 ! choline biosynthetic process [Term] id: GO:0033326 name: cerebrospinal fluid secretion namespace: biological_process def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451] synonym: "CSF secretion" EXACT [] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0033327 name: Leydig cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0033328 name: peroxisome membrane targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130, PMID:17020786] synonym: "mPTS binding" EXACT [] synonym: "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540] synonym: "PMP targeting signal (mPTS) binding" EXACT [PMID:14709540] synonym: "PMP targeting signal binding" EXACT [PMID:14709540] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0033329 name: kaempferol O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process [Term] id: GO:0033330 name: kaempferol O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside anabolism" EXACT [] synonym: "kaempferol O-glucoside biosynthesis" EXACT [] synonym: "kaempferol O-glucoside formation" EXACT [] synonym: "kaempferol O-glucoside synthesit" EXACT [] xref: MetaCyc:PWY-5320 is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0033329 ! kaempferol O-glucoside metabolic process is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0033331 name: ent-kaurene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] synonym: "ent-kaurene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0033332 name: ent-kaurene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] synonym: "ent-kaurene anabolism" EXACT [] synonym: "ent-kaurene biosynthesis" EXACT [] synonym: "ent-kaurene formation" EXACT [] synonym: "ent-kaurene synthesis" EXACT [] xref: MetaCyc:PWY-5032 xref: MetaCyc:PWY-5035 is_a: GO:0033331 ! ent-kaurene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0033333 name: fin development namespace: biological_process def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0048736 ! appendage development [Term] id: GO:0033334 name: fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a fin are generated and organized." [GOC:dgh] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0033333 ! fin development [Term] id: GO:0033335 name: anal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033336 name: caudal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033337 name: dorsal fin development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033338 ! medial fin development [Term] id: GO:0033338 name: medial fin development namespace: biological_process def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033339 name: pectoral fin development namespace: biological_process def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033340 name: pelvic fin development namespace: biological_process def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0033333 ! fin development [Term] id: GO:0033341 name: regulation of collagen binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005518 ! collagen binding relationship: regulates GO:0005518 ! collagen binding [Term] id: GO:0033342 name: negative regulation of collagen binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah] synonym: "down regulation of collagen binding" EXACT [] synonym: "down-regulation of collagen binding" EXACT [] synonym: "downregulation of collagen binding" EXACT [] synonym: "inhibition of collagen binding" NARROW [] is_a: GO:0033341 ! regulation of collagen binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005518 ! collagen binding relationship: negatively_regulates GO:0005518 ! collagen binding [Term] id: GO:0033343 name: positive regulation of collagen binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah] synonym: "activation of collagen binding" NARROW [] synonym: "stimulation of collagen binding" NARROW [] synonym: "up regulation of collagen binding" EXACT [] synonym: "up-regulation of collagen binding" EXACT [] synonym: "upregulation of collagen binding" EXACT [] is_a: GO:0033341 ! regulation of collagen binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005518 ! collagen binding relationship: positively_regulates GO:0005518 ! collagen binding [Term] id: GO:0033344 name: cholesterol efflux namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart] synonym: "cholesterol export" EXACT [] is_a: GO:0030301 ! cholesterol transport [Term] id: GO:0033345 name: asparagine catabolic process via L-aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] xref: MetaCyc:ASPARAGINE-DEG1-PWY is_a: GO:0006530 ! asparagine catabolic process [Term] id: GO:0033346 name: asparagine catabolic process via 2-oxosuccinamate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002] xref: MetaCyc:PWY-4002 is_a: GO:0006530 ! asparagine catabolic process [Term] id: GO:0033347 name: tetrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] synonym: "tetrose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0033348 name: tetrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] synonym: "tetrose anabolism" EXACT [] synonym: "tetrose biosynthesis" EXACT [] synonym: "tetrose formation" EXACT [] synonym: "tetrose synthesis" EXACT [] is_a: GO:0033347 ! tetrose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0033349 name: apiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah] synonym: "apiose metabolism" EXACT [] is_a: GO:0033347 ! tetrose metabolic process [Term] id: GO:0033350 name: apiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah] synonym: "apiose anabolism" EXACT [] synonym: "apiose biosynthesis" EXACT [] synonym: "apiose formation" EXACT [] synonym: "apiose synthesis" EXACT [] is_a: GO:0033348 ! tetrose biosynthetic process is_a: GO:0033349 ! apiose metabolic process [Term] id: GO:0033351 name: UDP-D-apiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-apiose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033352 name: UDP-D-apiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113] synonym: "UDP-D-apiose anabolism" EXACT [] synonym: "UDP-D-apiose biosynthesis" EXACT [] synonym: "UDP-D-apiose formation" EXACT [] synonym: "UDP-D-apiose synthesis" EXACT [] xref: MetaCyc:PWY-4821 xref: MetaCyc:PWY-5113 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033351 ! UDP-D-apiose metabolic process [Term] id: GO:0033353 name: S-adenosylmethionine cycle namespace: biological_process def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041] synonym: "activated methyl cycle" EXACT [] synonym: "SAM cycle" EXACT [] xref: MetaCyc:PWY-5041 is_a: GO:0046500 ! S-adenosylmethionine metabolic process relationship: has_part GO:0008898 ! S-adenosylmethionine-homocysteine S-methyltransferase activity [Term] id: GO:0033354 name: chlorophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068] xref: MetaCyc:PWY-5068 is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0033355 name: ascorbate glutathione cycle namespace: biological_process def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261] synonym: "hydrogen peroxide detoxification" RELATED [] xref: MetaCyc:PWY-2261 is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042744 ! hydrogen peroxide catabolic process [Term] id: GO:0033356 name: UDP-L-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-L-arabinose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033357 name: L-arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [GOC:mah] synonym: "L-arabinose anabolism" EXACT [] synonym: "L-arabinose biosynthesis" EXACT [] synonym: "L-arabinose formation" EXACT [] synonym: "L-arabinose synthesis" EXACT [] is_a: GO:0019567 ! arabinose biosynthetic process is_a: GO:0046373 ! L-arabinose metabolic process [Term] id: GO:0033358 name: UDP-L-arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82] synonym: "UDP-L-arabinose anabolism" EXACT [] synonym: "UDP-L-arabinose biosynthesis" EXACT [] synonym: "UDP-L-arabinose formation" EXACT [] synonym: "UDP-L-arabinose synthesis" EXACT [] xref: MetaCyc:PWY-63 xref: MetaCyc:PWY-82 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033356 ! UDP-L-arabinose metabolic process [Term] id: GO:0033359 name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-] synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] xref: MetaCyc:DAPLYSINESYN-PWY is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033360 name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941] synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] xref: MetaCyc:PWY-2941 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate [Term] id: GO:0033361 name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, GOC:pr, MetaCyc:PWY-2942] synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT [] synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT [] synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT [] xref: MetaCyc:PWY-2942 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate relationship: has_part GO:0047850 ! diaminopimelate dehydrogenase activity [Term] id: GO:0033362 name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, GOC:pr, MetaCyc:PWY-5097] synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate relationship: has_part GO:0008837 ! diaminopimelate epimerase activity relationship: has_part GO:0010285 ! L,L-diaminopimelate aminotransferase activity [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organisation" EXACT [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0033364 name: mast cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "mast cell secretory granule maturation" RELATED [] synonym: "mast cell secretory granule organisation" EXACT [GOC:mah] synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0033366 name: protein localization to secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] synonym: "protein localisation in secretory granule" EXACT [GOC:mah] synonym: "protein localization in secretory granule" EXACT [] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0033367 name: protein localization to mast cell secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] synonym: "protein localisation in mast cell secretory granule" EXACT [GOC:mah] synonym: "protein localization in mast cell secretory granule" EXACT [] is_a: GO:0033366 ! protein localization to secretory granule relationship: part_of GO:0033364 ! mast cell secretory granule organization [Term] id: GO:0033368 name: protease localization to mast cell secretory granule namespace: biological_process def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] synonym: "protease localisation in mast cell secretory granule" EXACT [GOC:mah] synonym: "protease localization in mast cell secretory granule" EXACT [] is_a: GO:0033367 ! protein localization to mast cell secretory granule [Term] id: GO:0033369 name: establishment of protein localization to mast cell secretory granule namespace: biological_process def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah] synonym: "establishment of protein localisation in mast cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protein localization in mast cell secretory granule" EXACT [] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule [Term] id: GO:0033370 name: maintenance of protein location in mast cell secretory granule namespace: biological_process def: "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "mast cell protein retention" EXACT [] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule [Term] id: GO:0033371 name: T cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "T cell secretory granule organisation" EXACT [GOC:mah] synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] synonym: "T lymphocyte secretory granule organization" EXACT [] synonym: "T-cell secretory granule organization" EXACT [] synonym: "T-lymphocyte secretory granule maturation" RELATED [] synonym: "T-lymphocyte secretory granule organization" EXACT [] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0033372 name: establishment of protease localization to mast cell secretory granule namespace: biological_process def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah] synonym: "establishment of protease localisation in mast cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protease localization in mast cell secretory granule" EXACT [] is_a: GO:0033369 ! establishment of protein localization to mast cell secretory granule relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule [Term] id: GO:0033373 name: maintenance of protease location in mast cell secretory granule namespace: biological_process def: "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "mast cell protease retention" EXACT [] is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule [Term] id: GO:0033374 name: protein localization to T cell secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protein localization in T cell secretory granule" EXACT [] synonym: "protein localization in T lymphocyte secretory granule" EXACT [] synonym: "protein localization in T-cell secretory granule" EXACT [] synonym: "protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033366 ! protein localization to secretory granule relationship: part_of GO:0033371 ! T cell secretory granule organization [Term] id: GO:0033375 name: protease localization to T cell secretory granule namespace: biological_process def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "protease localization in T cell secretory granule" EXACT [] synonym: "protease localization in T lymphocyte secretory granule" EXACT [] synonym: "protease localization in T-cell secretory granule" EXACT [] synonym: "protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033376 name: establishment of protein localization to T cell secretory granule namespace: biological_process def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of protein localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protein localization in T cell secretory granule" EXACT [] synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of protein localization in T-cell secretory granule" EXACT [] synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033377 name: maintenance of protein location in T cell secretory granule namespace: biological_process def: "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of protein localization in T-cell secretory granule" EXACT [] synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0033374 ! protein localization to T cell secretory granule [Term] id: GO:0033378 name: establishment of protease localization to T cell secretory granule namespace: biological_process def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of protease localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of protease localization in T cell secretory granule" EXACT [] synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of protease localization in T-cell secretory granule" EXACT [] synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033376 ! establishment of protein localization to T cell secretory granule relationship: part_of GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0033379 name: maintenance of protease location in T cell secretory granule namespace: biological_process def: "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of protease localization in T-cell secretory granule" EXACT [] synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule relationship: part_of GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0033380 name: granzyme B localization to T cell secretory granule namespace: biological_process def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "granzyme B localization in T cell secretory granule" EXACT [] synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "granzyme B localization in T-cell secretory granule" EXACT [] synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033375 ! protease localization to T cell secretory granule [Term] id: GO:0033381 name: establishment of granzyme B localization to T cell secretory granule namespace: biological_process def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah] synonym: "establishment of granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] synonym: "establishment of granzyme B localization in T cell secretory granule" EXACT [] synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT [] synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT [] synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED [] is_a: GO:0033378 ! establishment of protease localization to T cell secretory granule relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule [Term] id: GO:0033382 name: maintenance of granzyme B location in T cell secretory granule namespace: biological_process def: "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah] synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT [] synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT [] synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT [] is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule [Term] id: GO:0033383 name: geranyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] synonym: "geranyl diphosphate metabolism" EXACT [] synonym: "geranyldiphosphate metabolic process" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0033384 name: geranyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122] synonym: "geranyl diphosphate anabolism" EXACT [] synonym: "geranyl diphosphate biosynthesis" EXACT [] synonym: "geranyl diphosphate formation" EXACT [] synonym: "geranyl diphosphate synthesis" EXACT [] synonym: "geranyldiphosphate biosynthetic process" EXACT [] xref: MetaCyc:PWY-5122 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033383 ! geranyl diphosphate metabolic process [Term] id: GO:0033385 name: geranylgeranyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] synonym: "geranylgeranyl diphosphate metabolism" EXACT [] synonym: "geranylgeranyldiphosphate metabolic process" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0033386 name: geranylgeranyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120] synonym: "geranylgeranyl diphosphate anabolism" EXACT [] synonym: "geranylgeranyl diphosphate biosynthesis" EXACT [] synonym: "geranylgeranyl diphosphate formation" EXACT [] synonym: "geranylgeranyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5120 xref: MetaCyc:PWY-5121 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process [Term] id: GO:0033387 name: putrescine biosynthetic process from ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] synonym: "putrescine anabolism from ornithine" EXACT [] synonym: "putrescine biosynthesis from ornithine" EXACT [] synonym: "putrescine formation from ornithine" EXACT [] synonym: "putrescine synthesis from ornithine" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0009446 ! putrescine biosynthetic process [Term] id: GO:0033388 name: putrescine biosynthetic process from arginine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46] synonym: "putrescine anabolism from arginine" EXACT [] synonym: "putrescine biosynthesis from arginine" EXACT [] synonym: "putrescine formation from arginine" EXACT [] synonym: "putrescine synthesis from arginine" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009446 ! putrescine biosynthetic process [Term] id: GO:0033389 name: putrescine biosynthetic process from arginine, using agmatinase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40] synonym: "putrescine anabolism from arginine, using agmatinase" EXACT [] synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT [] synonym: "putrescine formation from arginine, using agmatinase" EXACT [] synonym: "putrescine synthesis from arginine, using agmatinase" EXACT [] is_a: GO:0033388 ! putrescine biosynthetic process from arginine [Term] id: GO:0033390 name: putrescine biosynthetic process from arginine via N-carbamoylputrescine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43] synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT [] synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT [] is_a: GO:0033388 ! putrescine biosynthetic process from arginine [Term] id: GO:0033391 name: chromatoid body namespace: cellular_component def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule [Term] id: GO:0033392 name: obsolete actin homodimerization activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an identical actin monomer to form a homodimer." [GOC:mah] comment: This term was made obsolete because it was added in error; formation of an actin dimer is simply a transient step in the polymerization of actin. Also, this term may not represent a real molecular function in GO, but rather that a gene product (actin itself) is part of an actin homodimer transient protein complex. synonym: "actin dimerization activity" BROAD [] synonym: "actin homodimerization activity" EXACT [] synonym: "actin polymerizing activity" RELATED [] is_obsolete: true [Term] id: GO:0033393 name: homogalacturonan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah] synonym: "homogalacturonan breakdown" EXACT [] synonym: "homogalacturonan catabolism" EXACT [] synonym: "homogalacturonan degradation" EXACT [] xref: MetaCyc:PWY-1081 is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0010394 ! homogalacturonan metabolic process [Term] id: GO:0033394 name: beta-alanine biosynthetic process via 1,3 diaminopropane namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981] synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT [] synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT [] xref: MetaCyc:PWY-3981 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033395 name: beta-alanine biosynthetic process via 3-hydroxypropionate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941] synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT [] synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT [] xref: MetaCyc:PWY-3941 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033396 name: beta-alanine biosynthetic process via 3-ureidopropionate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982] synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT [] synonym: "beta-alanine formation via 3-ureidopropionate" EXACT [] synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT [] xref: MetaCyc:PWY-3982 is_a: GO:0019483 ! beta-alanine biosynthetic process [Term] id: GO:0033397 name: zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "zeatin metabolism" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0033398 name: zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "zeatin anabolism" EXACT [] synonym: "zeatin biosynthesis" EXACT [] synonym: "zeatin formation" EXACT [] synonym: "zeatin synthesis" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0033397 ! zeatin metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0033399 name: cis-zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "cis-zeatin metabolism" EXACT [] is_a: GO:0033397 ! zeatin metabolic process [Term] id: GO:0033400 name: trans-zeatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "trans-zeatin metabolism" EXACT [] is_a: GO:0033397 ! zeatin metabolic process [Term] id: GO:0033401 name: UUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah] comment: Note that in the standard genetic code, TTT codes for phenylalanine. synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033402 name: UUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah] comment: Note that in the standard genetic code, TTC codes for phenylalanine. synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033403 name: UUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah] comment: Note that in the standard genetic code, TTA codes for leucine. synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033404 name: UUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah] comment: Note that in the standard genetic code, TTG codes for leucine. synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033405 name: UCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah] comment: Note that in the standard genetic code, TCT codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033406 name: UCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah] comment: Note that in the standard genetic code, TCC codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033407 name: UCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah] comment: Note that in the standard genetic code, TCA codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033408 name: UCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah] comment: Note that in the standard genetic code, TCG codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033409 name: UAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah] comment: Note that in the standard genetic code, TAT codes for tyrosine. synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033410 name: UAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah] comment: Note that in the standard genetic code, TAC codes for tyrosine. synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033411 name: UAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah] comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033412 name: UAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah] comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033413 name: UGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah] comment: Note that in the standard genetic code, TGT codes for cysteine. synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033414 name: UGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah] comment: Note that in the standard genetic code, TGC codes for cysteine. synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033415 name: UGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah] comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033416 name: UGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah] comment: Note that in the standard genetic code, TGG codes for tryptophan. synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033417 name: CUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah] comment: Note that in the standard genetic code, CTT codes for leucine. synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033418 name: CUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah] comment: Note that in the standard genetic code, CTC codes for leucine. synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033419 name: CUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah] comment: Note that in the standard genetic code, CTA codes for leucine. synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033420 name: CUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah] comment: Note that in the standard genetic code, CTG codes for leucine. synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033421 name: CCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah] comment: Note that in the standard genetic code, CCT codes for proline. synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033422 name: CCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah] comment: Note that in the standard genetic code, CCC codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033423 name: CCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah] comment: Note that in the standard genetic code, CCA codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033424 name: CCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah] comment: Note that in the standard genetic code, CCG codes for proline. synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033425 name: CAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah] comment: Note that in the standard genetic code, CAT codes for histidine. synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033426 name: CAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah] comment: Note that in the standard genetic code, CAC codes for histidine. synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033427 name: CAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah] comment: Note that in the standard genetic code, CAA codes for glutamine. synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033428 name: CAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah] comment: Note that in the standard genetic code, CAG codes for glutamine. synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033429 name: CGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah] comment: Note that in the standard genetic code, CGT codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033430 name: CGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah] comment: Note that in the standard genetic code, CGC codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033431 name: CGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah] comment: Note that in the standard genetic code, CGA codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033432 name: CGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah] comment: Note that in the standard genetic code, CGG codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033433 name: AUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah] comment: Note that in the standard genetic code, ATT codes for isoleucine. synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033434 name: AUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah] comment: Note that in the standard genetic code, ATC codes for isoleucine. synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033435 name: AUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah] comment: Note that in the standard genetic code, ATA codes for isoleucine. synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033436 name: AUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah] comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033437 name: ACU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah] comment: Note that in the standard genetic code, ACT codes for threonine. synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033438 name: ACC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah] comment: Note that in the standard genetic code, ACC codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033439 name: ACA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah] comment: Note that in the standard genetic code, ACA codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033440 name: ACG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah] comment: Note that in the standard genetic code, ACG codes for threonine. synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033441 name: AAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah] comment: Note that in the standard genetic code, AAT codes for asparagine. synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033442 name: AAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah] comment: Note that in the standard genetic code, AAC codes for asparagine. synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033443 name: AAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah] comment: Note that in the standard genetic code, AAA codes for lysine. synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033444 name: AAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah] comment: Note that in the standard genetic code, AAG codes for lysine. synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033445 name: AGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah] comment: Note that in the standard genetic code, AGT codes for serine. synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah] synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033446 name: AGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah] comment: Note that in the standard genetic code, AGC codes for serine. synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033447 name: AGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah] comment: Note that in the standard genetic code, AGA codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033448 name: AGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah] comment: Note that in the standard genetic code, AGG codes for arginine. synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033449 name: GUU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah] comment: Note that in the standard genetic code, GTT codes for valine. synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033450 name: GUC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah] comment: Note that in the standard genetic code, GTC codes for valine. synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033451 name: GUA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah] comment: Note that in the standard genetic code, GTA codes for valine. synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033452 name: GUG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah] comment: Note that in the standard genetic code, GTG codes for valine. synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033453 name: GCU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah] comment: Note that in the standard genetic code, GCT codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033454 name: GCC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah] comment: Note that in the standard genetic code, GCC codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033455 name: GCA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah] comment: Note that in the standard genetic code, GCA codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033456 name: GCG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah] comment: Note that in the standard genetic code, GCG codes for alanine. synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033457 name: GAU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah] comment: Note that in the standard genetic code, GAT codes for aspartic acid. synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033458 name: GAC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah] comment: Note that in the standard genetic code, GAC codes for aspartic acid. synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033459 name: GAA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah] comment: Note that in the standard genetic code, GAA codes for glutamic acid. synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033460 name: GAG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah] comment: Note that in the standard genetic code, GAG codes for glutamic acid. synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033461 name: GGU codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah] comment: Note that in the standard genetic code, GGT codes for glycine. synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd] synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033462 name: GGC codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah] comment: Note that in the standard genetic code, GGC codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033463 name: GGA codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah] comment: Note that in the standard genetic code, GGA codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033464 name: GGG codon-amino acid adaptor activity namespace: molecular_function def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah] comment: Note that in the standard genetic code, GGG codes for glycine. synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] is_a: GO:0030533 ! triplet codon-amino acid adaptor activity [Term] id: GO:0033465 name: cis-zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "cis-zeatin anabolism" EXACT [] synonym: "cis-zeatin biosynthesis" EXACT [] synonym: "cis-zeatin formation" EXACT [] synonym: "cis-zeatin synthesis" EXACT [] xref: MetaCyc:PWY-2781 is_a: GO:0033398 ! zeatin biosynthetic process is_a: GO:0033399 ! cis-zeatin metabolic process [Term] id: GO:0033466 name: trans-zeatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] synonym: "trans-zeatin anabolism" EXACT [] synonym: "trans-zeatin biosynthesis" EXACT [] synonym: "trans-zeatin formation" EXACT [] synonym: "trans-zeatin synthesis" EXACT [] xref: MetaCyc:PWY-2681 is_a: GO:0033398 ! zeatin biosynthetic process is_a: GO:0033400 ! trans-zeatin metabolic process [Term] id: GO:0033467 name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] synonym: "CMP-KDO metabolic process" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033468 name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] synonym: "CMP-KDO biosynthesis" EXACT [] synonym: "CMP-KDO biosynthetic process" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] xref: MetaCyc:KDOSYN-PWY xref: MetaCyc:PWY-1269 xref: MetaCyc:PWY-5111 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process [Term] id: GO:0033469 name: gibberellin 12 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah] synonym: "GA12 metabolic process" EXACT [] synonym: "gibberellin 12 metabolism" EXACT [] synonym: "gibberellin A12 metabolic process" EXACT [] is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0033470 name: gibberellin 12 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah] synonym: "GA12 biosynthetic process" EXACT [] synonym: "gibberellin 12 anabolism" EXACT [] synonym: "gibberellin 12 biosynthesis" EXACT [] synonym: "gibberellin 12 formation" EXACT [] synonym: "gibberellin 12 synthesis" EXACT [] synonym: "gibberellin A12 biosynthetic process" EXACT [] xref: MetaCyc:PWY-5034 is_a: GO:0009686 ! gibberellin biosynthetic process is_a: GO:0033469 ! gibberellin 12 metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0033471 name: GDP-L-galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] synonym: "GDP-L-galactose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033472 name: GDP-L-galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] synonym: "GDP-L-galactose anabolism" EXACT [] synonym: "GDP-L-galactose biosynthesis" EXACT [] synonym: "GDP-L-galactose formation" EXACT [] synonym: "GDP-L-galactose synthesis" EXACT [] xref: MetaCyc:PWY-5115 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033471 ! GDP-L-galactose metabolic process [Term] id: GO:0033473 name: indoleacetic acid conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] synonym: "IAA conjugate metabolic process" EXACT [] synonym: "indole acetic acid conjugate metabolic process" EXACT [] synonym: "indole acetic acid conjugate metabolism" EXACT [] synonym: "indoleacetic acid conjugate metabolism" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process [Term] id: GO:0033474 name: indoleacetic acid conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] synonym: "IAA conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid conjugate biosynthesis" EXACT [] synonym: "indole acetic acid conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid conjugate anabolism" EXACT [] synonym: "indoleacetic acid conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid conjugate formation" EXACT [] synonym: "indoleacetic acid conjugate synthesis" EXACT [] is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0033475 name: indoleacetic acid amide conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782] synonym: "IAA amide conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid amide conjugate biosynthesis" EXACT [] synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid amide conjugate anabolism" EXACT [] synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid amide conjugate formation" EXACT [] synonym: "indoleacetic acid amide conjugate synthesis" EXACT [] xref: MetaCyc:PWY-1782 is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0033476 name: indoleacetic acid ester conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741] synonym: "IAA ester conjugate biosynthetic process" EXACT [] synonym: "indole acetic acid ester conjugate biosynthesis" EXACT [] synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT [] synonym: "indoleacetic acid ester conjugate anabolism" EXACT [] synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT [] synonym: "indoleacetic acid ester conjugate formation" EXACT [] synonym: "indoleacetic acid ester conjugate synthesis" EXACT [] xref: MetaCyc:PWY-1741 is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process [Term] id: GO:0033477 name: S-methylmethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340] synonym: "S-methylmethionine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0033478 name: UDP-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748] synonym: "UDP-rhamnose metabolism" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033479 name: UDP-D-galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-galacturonate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0033480 name: UDP-D-galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] synonym: "UDP-D-galacturonate anabolism" EXACT [] synonym: "UDP-D-galacturonate biosynthesis" EXACT [] synonym: "UDP-D-galacturonate formation" EXACT [] synonym: "UDP-D-galacturonate synthesis" EXACT [] xref: MetaCyc:PWY-4 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033479 ! UDP-D-galacturonate metabolic process [Term] id: GO:0033481 name: galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah] synonym: "galacturonate anabolism" EXACT [] synonym: "galacturonate biosynthesis" EXACT [] synonym: "galacturonate formation" EXACT [] synonym: "galacturonate synthesis" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0033482 name: D-galacturonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah] synonym: "D-galacturonate anabolism" EXACT [] synonym: "D-galacturonate biosynthesis" EXACT [] synonym: "D-galacturonate formation" EXACT [] synonym: "D-galacturonate synthesis" EXACT [] is_a: GO:0033481 ! galacturonate biosynthetic process is_a: GO:0046396 ! D-galacturonate metabolic process [Term] id: GO:0033483 name: gas homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0033484 name: nitric oxide homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell." [GOC:mah] synonym: "NO homeostasis" EXACT [] is_a: GO:0033483 ! gas homeostasis [Term] id: GO:0033485 name: cyanidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] synonym: "cyanidin 3-O-glucoside anabolism" EXACT [] synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT [] synonym: "cyanidin 3-O-glucoside formation" EXACT [] synonym: "cyanidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5125 is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:1901038 ! cyanidin 3-O-glucoside metabolic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0033486 name: delphinidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153] synonym: "delphinidin 3-O-glucoside anabolism" EXACT [] synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT [] synonym: "delphinidin 3-O-glucoside formation" EXACT [] synonym: "delphinidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5153 is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0033487 name: pelargonidin 3-O-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] synonym: "pelargonidin 3-O-glucoside anabolism" EXACT [] synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT [] synonym: "pelargonidin 3-O-glucoside formation" EXACT [] synonym: "pelargonidin 3-O-glucoside synthesis" EXACT [] xref: MetaCyc:PWY-5125 is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0033488 name: cholesterol biosynthetic process via 24,25-dihydrolanosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3] synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT [] synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT [] xref: MetaCyc:PWY66-3 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033489 name: cholesterol biosynthetic process via desmosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4] synonym: "cholesterol anabolism via desmosterol" EXACT [] synonym: "cholesterol biosynthesis via desmosterol" EXACT [] synonym: "cholesterol formation via desmosterol" EXACT [] synonym: "cholesterol synthesis via desmosterol" EXACT [] xref: MetaCyc:PWY66-4 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033490 name: cholesterol biosynthetic process via lathosterol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341] synonym: "cholesterol anabolism via lathosterol" EXACT [] synonym: "cholesterol biosynthesis via lathosterol" EXACT [] synonym: "cholesterol formation via lathosterol" EXACT [] synonym: "cholesterol synthesis via lathosterol" EXACT [] xref: MetaCyc:PWY66-341 is_a: GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0033491 name: coniferin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [GOC:mah, MetaCyc:PWY-116] synonym: "coniferin metabolism" EXACT [] xref: MetaCyc:PWY-116 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process [Term] id: GO:0033492 name: esculetin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah] synonym: "esculetin metabolism" EXACT [] is_a: GO:0009804 ! coumarin metabolic process [Term] id: GO:0033493 name: esculetin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah] synonym: "esculetin anabolism" EXACT [] synonym: "esculetin biosynthesis" EXACT [] synonym: "esculetin formation" EXACT [] synonym: "esculetin synthesis" EXACT [] xref: MetaCyc:PWY-5349 is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:0033492 ! esculetin metabolic process [Term] id: GO:0033494 name: ferulate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "ferulate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0033495 name: ferulate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "ferulate anabolism" EXACT [] synonym: "ferulate biosynthesis" EXACT [] synonym: "ferulate formation" EXACT [] synonym: "ferulate synthesis" EXACT [] xref: MetaCyc:PWY-5168 is_a: GO:0033494 ! ferulate metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0033496 name: sinapate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "sinapate metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0033497 name: sinapate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "sinapate anabolism" EXACT [] synonym: "sinapate biosynthesis" EXACT [] synonym: "sinapate formation" EXACT [] synonym: "sinapate synthesis" EXACT [] xref: MetaCyc:PWY-5168 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0033496 ! sinapate metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0033498 name: galactose catabolic process via D-galactonate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY] synonym: "galactose breakdown via D-galactonate" EXACT [] synonym: "galactose catabolism via D-galactonate" EXACT [] synonym: "galactose degradation via D-galactonate" EXACT [] xref: MetaCyc:GALDEG-PWY is_a: GO:0019388 ! galactose catabolic process [Term] id: GO:0033499 name: galactose catabolic process via UDP-galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821] synonym: "galactose breakdown via UDP-galactose" EXACT [] synonym: "galactose catabolism via UDP-galactose" EXACT [] synonym: "galactose degradation via UDP-galactose" EXACT [] synonym: "Leloir Pathway" RELATED [PMID:14741191] xref: MetaCyc:PWY-3821 is_a: GO:0019388 ! galactose catabolic process [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0033501 name: galactose homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah] is_a: GO:0033500 ! carbohydrate homeostasis [Term] id: GO:0033502 name: cellular galactose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0033501 ! galactose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0033503 name: HULC complex namespace: cellular_component def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0031371 ! ubiquitin conjugating enzyme complex relationship: part_of GO:0000792 ! heterochromatin [Term] id: GO:0033504 name: floor plate development namespace: biological_process def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0033505 name: floor plate morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0033504 ! floor plate development [Term] id: GO:0033506 name: glucosinolate biosynthetic process from homomethionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187] synonym: "glucosinolate anabolism from homomethionine" EXACT [] synonym: "glucosinolate biosynthesis from homomethionine" EXACT [] synonym: "glucosinolate formation from homomethionine" EXACT [] synonym: "glucosinolate synthesis from homomethionine" EXACT [] xref: MetaCyc:PWY-1187 is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:0033321 ! homomethionine metabolic process [Term] id: GO:0033507 name: glucosinolate biosynthetic process from phenylalanine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821] synonym: "glucosinolate anabolism from phenylalanine" EXACT [] synonym: "glucosinolate biosynthesis from phenylalanine" EXACT [] synonym: "glucosinolate formation from phenylalanine" EXACT [] synonym: "glucosinolate synthesis from phenylalanine" EXACT [] xref: MetaCyc:PWY-2821 is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0033508 name: glutamate catabolic process to butyrate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087] synonym: "glutamate breakdown to butyrate" EXACT [] synonym: "glutamate degradation to butyrate" EXACT [] xref: MetaCyc:PWY-5087 is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0019605 ! butyrate metabolic process [Term] id: GO:0033509 name: glutamate catabolic process to propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088] synonym: "glutamate breakdown to propionate" EXACT [] synonym: "glutamate degradation to propionate" EXACT [] xref: MetaCyc:PWY-5088 is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0033510 name: luteolin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah] synonym: "luteolin metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0033511 name: luteolin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah] synonym: "luteolin anabolism" EXACT [] synonym: "luteolin biosynthesis" EXACT [] synonym: "luteolin formation" EXACT [] synonym: "luteolin synthesis" EXACT [] xref: MetaCyc:PWY-5060 is_a: GO:0033510 ! luteolin metabolic process is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0033512 name: L-lysine catabolic process to acetyl-CoA via saccharopine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY] synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT [] xref: MetaCyc:LYSINE-DEG1-PWY is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033513 name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280] synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT [] xref: MetaCyc:PWY-5280 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033514 name: L-lysine catabolic process to acetyl-CoA via L-pipecolate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283] synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT [] synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT [] xref: MetaCyc:PWY-5283 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033515 name: L-lysine catabolic process using lysine 6-aminotransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298] synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah] synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah] xref: MetaCyc:PWY-5298 is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA [Term] id: GO:0033516 name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702] synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:PWY-702 is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0033517 name: myo-inositol hexakisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538] synonym: "myo-inositol hexakisphosphate metabolism" EXACT [] synonym: "phytate metabolic process" EXACT [] synonym: "phytate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0033518 name: myo-inositol hexakisphosphate dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah] synonym: "phytate dephosphorylation" EXACT [] xref: MetaCyc:PWY-4702 xref: MetaCyc:PWY-4781 is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process is_a: GO:0046855 ! inositol phosphate dephosphorylation [Term] id: GO:0033519 name: phytyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah] synonym: "phytyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0033520 name: phytol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah] synonym: "phytol anabolism" EXACT [] synonym: "phytol biosynthesis" EXACT [] synonym: "phytol formation" EXACT [] synonym: "phytol synthesis" EXACT [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0033306 ! phytol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:1903175 ! fatty alcohol biosynthetic process [Term] id: GO:0033521 name: phytyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah] synonym: "phytyl diphosphate anabolism" EXACT [] synonym: "phytyl diphosphate biosynthesis" EXACT [] synonym: "phytyl diphosphate formation" EXACT [] synonym: "phytyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5063 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0033519 ! phytyl diphosphate metabolic process [Term] id: GO:0033522 name: histone H2A ubiquitination namespace: biological_process def: "The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235] is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0033523 name: histone H2B ubiquitination namespace: biological_process def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah] is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0033524 name: sinapate ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "sinapate ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0033525 name: sinapate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "sinapate ester anabolism" EXACT [] synonym: "sinapate ester biosynthesis" EXACT [] synonym: "sinapate ester formation" EXACT [] synonym: "sinapate ester synthesis" EXACT [] xref: MetaCyc:PWY-3301 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0033524 ! sinapate ester metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0033526 name: tetrapyrrole biosynthetic process from glutamate namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [GOC:mah, MetaCyc:PWY-5188] synonym: "tetrapyrrole anabolism from glutamate" EXACT [] synonym: "tetrapyrrole biosynthesis from glutamate" EXACT [] synonym: "tetrapyrrole formation from glutamate" EXACT [] synonym: "tetrapyrrole synthesis from glutamate" EXACT [] xref: MetaCyc:PWY-5188 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process [Term] id: GO:0033527 name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [GOC:mah, MetaCyc:PWY-5189] synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT [] synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [] xref: MetaCyc:PWY-5189 is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0006544 ! glycine metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process [Term] id: GO:0033528 name: S-methylmethionine cycle namespace: biological_process def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441] xref: MetaCyc:PWY-5441 is_a: GO:0033477 ! S-methylmethionine metabolic process [Term] id: GO:0033529 name: raffinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] synonym: "raffinose anabolism" EXACT [] synonym: "raffinose biosynthesis" EXACT [] synonym: "raffinose formation" EXACT [] synonym: "raffinose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033530 ! raffinose metabolic process [Term] id: GO:0033530 name: raffinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] synonym: "raffinose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033531 name: stachyose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] synonym: "stachyose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033532 name: stachyose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] synonym: "stachyose anabolism" EXACT [] synonym: "stachyose biosynthesis" EXACT [] synonym: "stachyose formation" EXACT [] synonym: "stachyose synthesis" EXACT [] xref: MetaCyc:PWY-5337 is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033531 ! stachyose metabolic process [Term] id: GO:0033533 name: verbascose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] synonym: "verbascose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033534 name: verbascose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] synonym: "verbascose anabolism" EXACT [] synonym: "verbascose biosynthesis" EXACT [] synonym: "verbascose formation" EXACT [] synonym: "verbascose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033533 ! verbascose metabolic process [Term] id: GO:0033535 name: ajugose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] synonym: "ajugose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process [Term] id: GO:0033536 name: ajugose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] synonym: "ajugose anabolism" EXACT [] synonym: "ajugose biosynthesis" EXACT [] synonym: "ajugose formation" EXACT [] synonym: "ajugose synthesis" EXACT [] is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process is_a: GO:0033535 ! ajugose metabolic process [Term] id: GO:0033537 name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342] synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT [] synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT [] xref: MetaCyc:PWY-5342 is_a: GO:0033536 ! ajugose biosynthetic process [Term] id: GO:0033538 name: ajugose biosynthetic process using galactan:galactan galactosyltransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343] synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT [] synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT [] xref: MetaCyc:PWY-5343 is_a: GO:0033536 ! ajugose biosynthetic process [Term] id: GO:0033539 name: fatty acid beta-oxidation using acyl-CoA dehydrogenase namespace: biological_process def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136] xref: MetaCyc:FAO-PWY is_a: GO:0006635 ! fatty acid beta-oxidation relationship: has_part GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0033540 name: fatty acid beta-oxidation using acyl-CoA oxidase namespace: biological_process def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136] xref: MetaCyc:PWY-5136 is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033541 name: fatty acid beta-oxidation, unsaturated, odd number namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137] xref: MetaCyc:PWY-5137 is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033542 name: fatty acid beta-oxidation, unsaturated, even number namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] xref: MetaCyc:PWY-5138 is_a: GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0033543 name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] id: GO:0033544 name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway namespace: biological_process def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number [Term] id: GO:0033545 name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-6555] synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT [] synonym: "phytate biosynthesis, lipid-dependent" EXACT [] synonym: "phytate biosynthetic process, lipid-dependent" EXACT [] xref: MetaCyc:PWY-6555 is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process [Term] id: GO:0033546 name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-6554] synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT [] xref: MetaCyc:PWY-6554 is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent [Term] id: GO:0033547 name: obsolete myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541] comment: This term was made obsolete because its only cross-reference points to a MetaCyc entry (PWY-4541) that was deleted from the MetaCyc database. synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] xref: MetaCyc:PWY-4541 is_obsolete: true [Term] id: GO:0033548 name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661] synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT [] synonym: "phytate biosynthesis, lipid-independent" EXACT [] synonym: "phytate biosynthetic process, lipid-independent" EXACT [] xref: MetaCyc:PWY-4661 is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process [Term] id: GO:0033549 name: MAP kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316] synonym: "MAPK phosphatase activity" EXACT [PMID:12184814] is_a: GO:0004721 ! phosphoprotein phosphatase activity relationship: part_of GO:0000188 ! inactivation of MAPK activity [Term] id: GO:0033550 name: MAP kinase tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah] synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT [] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity relationship: part_of GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [Term] id: GO:0033551 name: monopolin complex namespace: cellular_component def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824] synonym: "monopolin subcomplex Csm1/Lrs4" NARROW [] synonym: "Pcs1/Mde4 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0033552 name: response to vitamin B3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl] synonym: "response to niacin" NARROW [] synonym: "response to nicotinamide" NARROW [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0033553 name: rDNA heterochromatin namespace: cellular_component def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah] synonym: "ribosomal DNA heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033555 name: multicellular organismal response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] is_a: GO:0006950 ! response to stress is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0033556 name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995] synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033557 name: Slx1-Slx4 complex namespace: cellular_component def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0033558 name: protein deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] xref: Reactome:R-HSA-5693092 "Unknown deacetylase deacetylates 7K-BACE1(46-501)" xref: Reactome:R-HSA-8952069 "HDAC4 deacetylates RUNX3" xref: Reactome:R-HSA-9626962 "SIRT1 deacetylates FOXO1" is_a: GO:0019213 ! deacetylase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006476 ! protein deacetylation [Term] id: GO:0033559 name: unsaturated fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah] synonym: "unsaturated fatty acid metabolism" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0033560 name: folate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde] xref: Reactome:R-HSA-197963 "Folate is reduced to dihydrofolate (DHF)" xref: Reactome:R-HSA-197972 "DHF is reduced to tetrahydrofolate (THF)" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0033561 name: regulation of water loss via skin namespace: biological_process def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah] synonym: "skin barrier function" RELATED [] is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0033562 name: co-transcriptional gene silencing by RNA interference machinery namespace: biological_process def: "A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin." [GOC:mah, GOC:vw, PMID:17512405, PMID:21151114, PMID:22431512] synonym: "co-transcriptional gene silencing by small RNA" EXACT [GOC:vw] synonym: "cotranscriptional gene silencing by RNA interference machinery" RELATED [] synonym: "cotranscriptional gene silencing by small RNA" RELATED [] synonym: "RNAi-mediated CTGS" EXACT [GOC:vw] synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0033563 name: dorsal/ventral axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb] synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah] synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah] synonym: "dorsoventral axon guidance" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0033564 name: anterior/posterior axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb] synonym: "anterior-posterior axon guidance" EXACT [] synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0033565 name: ESCRT-0 complex namespace: cellular_component def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868] synonym: "Hrs/STAM complex" EXACT [] synonym: "Vps27p-Hse1p complex" EXACT [] is_a: GO:0036452 ! ESCRT complex [Term] id: GO:0033566 name: gamma-tubulin complex localization namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT [] synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization [Term] id: GO:0033567 name: DNA replication, Okazaki fragment processing namespace: biological_process def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006273 ! lagging strand elongation [Term] id: GO:0033568 name: lactoferrin receptor activity namespace: molecular_function def: "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH." [GOC:bf, GOC:mlg, PMID:16261254] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0033569 name: lactoferrin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0033571 ! lactoferrin transport [Term] id: GO:0033570 name: obsolete transferrin transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of transferrin from one side of a membrane to the other." [GOC:mlg] comment: This term was obsoleted because there is no evidence that this function exists. See https://github.com/geneontology/go-ontology/issues/17157 is_obsolete: true [Term] id: GO:0033571 name: lactoferrin transport namespace: biological_process def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] is_a: GO:0006826 ! iron ion transport is_a: GO:0015031 ! protein transport [Term] id: GO:0033572 name: transferrin transport namespace: biological_process def: "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "melanotransferrin transport" EXACT [PR:000001887] is_a: GO:0006826 ! iron ion transport is_a: GO:0015031 ! protein transport [Term] id: GO:0033573 name: high-affinity iron permease complex namespace: cellular_component def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jp, PMID:16522632, PMID:8599111] synonym: "high affinity iron permease complex" EXACT [] xref: IntAct:EBI-12592666 is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1902495 ! transmembrane transporter complex is_a: GO:1905862 ! ferroxidase complex [Term] id: GO:0033574 name: response to testosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] synonym: "response to testosterone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901654 ! response to ketone [Term] id: GO:0033575 name: protein glycosylation at cell surface namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell." [GOC:mah, GOC:pr, PMID:12042244] synonym: "protein amino acid glycosylation at cell surface" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0033576 name: protein glycosylation in cytosol namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244] synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol [Term] id: GO:0033577 name: protein glycosylation in endoplasmic reticulum namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244] synonym: "core glycosylation" RELATED [PMID:6345657] synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein amino acid glycosylation in ER" EXACT [] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum relationship: occurs_in GO:0005783 ! endoplasmic reticulum [Term] id: GO:0033578 name: protein glycosylation in Golgi namespace: biological_process def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244] synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf] synonym: "terminal glycosylation" NARROW [PMID:6345657] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005794 ! Golgi apparatus relationship: occurs_in GO:0005794 ! Golgi apparatus [Term] id: GO:0033579 name: protein galactosylation in endoplasmic reticulum namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah] synonym: "protein amino acid galactosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein amino acid galactosylation in ER" EXACT [] is_a: GO:0033577 ! protein glycosylation in endoplasmic reticulum is_a: GO:0042125 ! protein galactosylation intersection_of: GO:0042125 ! protein galactosylation intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum [Term] id: GO:0033580 name: protein galactosylation at cell surface namespace: biological_process def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah] synonym: "protein amino acid galactosylation at cell surface" EXACT [GOC:bf] is_a: GO:0033575 ! protein glycosylation at cell surface is_a: GO:0042125 ! protein galactosylation [Term] id: GO:0033581 name: protein galactosylation in Golgi namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah] synonym: "protein amino acid galactosylation in Golgi" EXACT [GOC:bf] is_a: GO:0033578 ! protein glycosylation in Golgi is_a: GO:0042125 ! protein galactosylation intersection_of: GO:0042125 ! protein galactosylation intersection_of: occurs_in GO:0005794 ! Golgi apparatus [Term] id: GO:0033582 name: protein galactosylation in cytosol namespace: biological_process def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah] synonym: "protein amino acid galactosylation in cytosol" EXACT [GOC:bf] is_a: GO:0033576 ! protein glycosylation in cytosol is_a: GO:0042125 ! protein galactosylation intersection_of: GO:0042125 ! protein galactosylation intersection_of: occurs_in GO:0005829 ! cytosol [Term] id: GO:0033583 name: rhabdomere membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0033584 name: tyrosine biosynthetic process from chorismate via L-arogenate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah, MetaCyc:PWY-3461] synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT [] synonym: "tyrosine formation from chorismate via L-arogenate" EXACT [] synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT [] xref: MetaCyc:PWY-3461 is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0033585 name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators] synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT [] synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT [] xref: MetaCyc:PHESYN is_a: GO:0009094 ! L-phenylalanine biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0033586 name: L-phenylalanine biosynthetic process from chorismate via L-arogenate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators] synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT [] synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT [] xref: MetaCyc:PWY-3462 is_a: GO:0009094 ! L-phenylalanine biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0033587 name: shikimate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [GOC:mah] synonym: "shikimate anabolism" EXACT [] synonym: "shikimate biosynthesis" EXACT [] synonym: "shikimate formation" EXACT [] synonym: "shikimate synthesis" EXACT [] is_a: GO:0019632 ! shikimate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0033588 name: Elongator holoenzyme complex namespace: cellular_component alt_id: GO:0033589 def: "A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209] comment: Despite its name, this complex is no longer thought to be directly involved in transcriptional elongation (PMID:23165209). synonym: "Elongator core complex" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0033590 name: response to cobalamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl] synonym: "response to vitamin B12" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug [Term] id: GO:0033591 name: response to L-ascorbic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl] synonym: "response to ascorbic acid" BROAD [] synonym: "response to L-ascorbate" EXACT [] synonym: "response to vitamin C" EXACT [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0033273 ! response to vitamin is_a: GO:0034284 ! response to monosaccharide [Term] id: GO:0033592 name: RNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah] is_a: GO:0003725 ! double-stranded RNA binding is_a: GO:0003727 ! single-stranded RNA binding is_a: GO:0097617 ! annealing activity [Term] id: GO:0033593 name: BRCA2-MAGE-D1 complex namespace: cellular_component def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0033594 name: response to hydroxyisoflavone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah] is_a: GO:0080184 ! response to phenylpropanoid is_a: GO:1901654 ! response to ketone [Term] id: GO:0033595 name: response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0033594 ! response to hydroxyisoflavone is_a: GO:0097327 ! response to antineoplastic agent [Term] id: GO:0033596 name: TSC1-TSC2 complex namespace: cellular_component def: "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] synonym: "tuberin-hamartin complex" EXACT [] synonym: "tuberous sclerosis complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0033597 name: mitotic checkpoint complex namespace: cellular_component def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307] synonym: "MCC" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990298 ! bub1-bub3 complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033598 name: mammary gland epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0061180 ! mammary gland epithelium development [Term] id: GO:0033599 name: regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033598 ! mammary gland epithelial cell proliferation relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033600 name: negative regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW [] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033601 name: positive regulation of mammary gland epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] synonym: "activation of mammary gland epithelial cell proliferation" NARROW [] synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW [] synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT [] synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT [] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation [Term] id: GO:0033602 name: negative regulation of dopamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "down regulation of dopamine secretion" EXACT [] synonym: "down-regulation of dopamine secretion" EXACT [] synonym: "downregulation of dopamine secretion" EXACT [] synonym: "inhibition of dopamine secretion" NARROW [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014046 ! dopamine secretion relationship: negatively_regulates GO:0014046 ! dopamine secretion [Term] id: GO:0033603 name: positive regulation of dopamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] synonym: "activation of dopamine secretion" NARROW [] synonym: "stimulation of dopamine secretion" NARROW [] synonym: "up regulation of dopamine secretion" EXACT [] synonym: "up-regulation of dopamine secretion" EXACT [] synonym: "upregulation of dopamine secretion" EXACT [] is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014046 ! dopamine secretion relationship: positively_regulates GO:0014046 ! dopamine secretion [Term] id: GO:0033604 name: negative regulation of catecholamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "down regulation of catecholamine secretion" EXACT [] synonym: "down-regulation of catecholamine secretion" EXACT [] synonym: "downregulation of catecholamine secretion" EXACT [] synonym: "inhibition of catecholamine secretion" NARROW [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050432 ! catecholamine secretion relationship: negatively_regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0033605 name: positive regulation of catecholamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "activation of catecholamine secretion" NARROW [] synonym: "stimulation of catecholamine secretion" NARROW [] synonym: "up regulation of catecholamine secretion" EXACT [] synonym: "up-regulation of catecholamine secretion" EXACT [] synonym: "upregulation of catecholamine secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050432 ! catecholamine secretion relationship: positively_regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0033606 name: chemokine receptor transport within lipid bilayer namespace: biological_process def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah] synonym: "chemokine receptor translocation within membrane" EXACT [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0033607 name: SOD1-Bcl-2 complex namespace: cellular_component def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0033608 name: formyl-CoA transferase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16545] synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16] xref: EC:2.8.3.16 xref: KEGG_REACTION:R07290 xref: MetaCyc:RXN0-1382 xref: RHEA:16545 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0033609 name: oxalate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [GOC:mlg] synonym: "ethanedioate metabolic process" EXACT [] synonym: "ethanedioic acid metabolic process" EXACT [] synonym: "oxalate metabolism" EXACT [] synonym: "oxalic acid metabolic process" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0033610 name: oxalate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [GOC:mlg] synonym: "ethanedioate biosynthetic process" EXACT [] synonym: "ethanedioic acid biosynthetic process" EXACT [] synonym: "oxalate anabolism" EXACT [] synonym: "oxalate biosynthesis" EXACT [] synonym: "oxalate formation" EXACT [] synonym: "oxalate synthesis" EXACT [] synonym: "oxalic acid biosynthetic process" EXACT [] is_a: GO:0033609 ! oxalate metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0033611 name: oxalate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [GOC:mlg] synonym: "ethanedioate catabolic process" EXACT [] synonym: "ethanedioic acid catabolic process" EXACT [] synonym: "oxalate breakdown" EXACT [] synonym: "oxalate catabolism" EXACT [] synonym: "oxalate degradation" EXACT [] synonym: "oxalic acid catabolic process" EXACT [] is_a: GO:0033609 ! oxalate metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0033612 name: receptor serine/threonine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0033613 name: activating transcription factor binding namespace: molecular_function alt_id: GO:0001107 def: "Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah, GOC:txnOH] synonym: "transcription activator binding" EXACT [] is_a: GO:0140297 ! DNA-binding transcription factor binding [Term] id: GO:0033614 name: chloroplast proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly relationship: part_of GO:0009658 ! chloroplast organization [Term] id: GO:0033615 name: mitochondrial proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly intersection_of: GO:0043461 ! proton-transporting ATP synthase complex assembly intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0033616 name: plasma membrane proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah] is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0033617 name: mitochondrial respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah] synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD [] synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0008535 ! respiratory chain complex IV assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly intersection_of: GO:0008535 ! respiratory chain complex IV assembly intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0033618 name: plasma membrane respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah] synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD [] synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0008535 ! respiratory chain complex IV assembly relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0033619 name: membrane protein proteolysis namespace: biological_process def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde] is_a: GO:0006508 ! proteolysis [Term] id: GO:0033620 name: Mei2 nuclear dot complex namespace: cellular_component def: "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [GOC:vw, PMID:12808043] synonym: "Mei2 dot" EXACT [] synonym: "Mei2 nuclear dot" BROAD [] synonym: "nuclear body" RELATED [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0033621 name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts namespace: biological_process def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445] comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing. synonym: "degradation of meiosis-specific transcripts" EXACT [] synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT [] synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT [] synonym: "mRNA degradation, meiosis-specific transcripts" EXACT [] synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0033622 name: integrin activation namespace: biological_process def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] synonym: "integrin complex activation" EXACT [] synonym: "integrin complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0033623 name: regulation of integrin activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "regulation of integrin complex activation" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033622 ! integrin activation relationship: regulates GO:0033622 ! integrin activation [Term] id: GO:0033624 name: negative regulation of integrin activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "negative regulation of integrin complex activation" EXACT [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0033623 ! regulation of integrin activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033622 ! integrin activation relationship: negatively_regulates GO:0033622 ! integrin activation [Term] id: GO:0033625 name: positive regulation of integrin activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add] synonym: "positive regulation of integrin complex activation" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0033623 ! regulation of integrin activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033622 ! integrin activation relationship: positively_regulates GO:0033622 ! integrin activation [Term] id: GO:0033626 name: positive regulation of integrin activation by cell surface receptor linked signal transduction namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell surface receptor linked signal transduction leading to integrin activation" EXACT [GOC:bf, GOC:signaling] synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0033625 ! positive regulation of integrin activation intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: positively_regulates GO:0033622 ! integrin activation [Term] id: GO:0033627 name: cell adhesion mediated by integrin namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0007155 ! cell adhesion [Term] id: GO:0033628 name: regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033627 ! cell adhesion mediated by integrin relationship: regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033629 name: negative regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033630 name: positive regulation of cell adhesion mediated by integrin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033627 ! cell adhesion mediated by integrin relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin [Term] id: GO:0033631 name: cell-cell adhesion mediated by integrin namespace: biological_process def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] synonym: "cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0033627 ! cell adhesion mediated by integrin is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0033632 name: regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033631 ! cell-cell adhesion mediated by integrin relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033633 name: negative regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033634 name: positive regulation of cell-cell adhesion mediated by integrin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin [Term] id: GO:0033635 name: modulation by symbiont of host response to abiotic stimulus namespace: biological_process def: "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0009628 ! response to abiotic stimulus relationship: regulates GO:0009628 ! response to abiotic stimulus [Term] id: GO:0033636 name: modulation by symbiont of host response to temperature stimulus namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modulation by symbiont of host response to thermal stimulus" EXACT [] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0009266 ! response to temperature stimulus relationship: regulates GO:0009266 ! response to temperature stimulus [Term] id: GO:0033637 name: modulation by symbiont of host response to cold namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "freezing tolerance" RELATED [] is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus [Term] id: GO:0033638 name: modulation by symbiont of host response to heat namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response to heat shock" RELATED [] is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus [Term] id: GO:0033639 name: modulation by symbiont of host response to water namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus [Term] id: GO:0033640 name: modulation by symbiont of host response to osmotic stress namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus is_a: GO:0047484 ! regulation of response to osmotic stress intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0006970 ! response to osmotic stress [Term] id: GO:0033641 name: modulation by symbiont of host response to pH namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0009268 ! response to pH relationship: regulates GO:0009268 ! response to pH [Term] id: GO:0033642 name: modulation by symbiont of host response to gravitational stimulus namespace: biological_process def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response to gravitational stimulus" BROAD [] is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0009629 ! response to gravity relationship: regulates GO:0009629 ! response to gravity [Term] id: GO:0033643 name: host cell part namespace: cellular_component def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0018995 ! host cellular component intersection_of: GO:0018995 ! host cellular component intersection_of: part_of GO:0043657 ! host cell relationship: part_of GO:0043657 ! host cell [Term] id: GO:0033644 name: host cell membrane namespace: cellular_component def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033643 ! host cell part [Term] id: GO:0033645 name: host cell endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033644 ! host cell membrane [Term] id: GO:0033646 name: host intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "host cell intracellular part" EXACT [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0043656 ! host intracellular region [Term] id: GO:0033647 name: host intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033646 ! host intracellular part [Term] id: GO:0033648 name: host intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0033647 ! host intracellular organelle [Term] id: GO:0033650 name: host cell mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "host mitochondria" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0033651 name: host cell plastid namespace: cellular_component def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0033652 name: host cell chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033651 ! host cell plastid [Term] id: GO:0033653 name: host cell chloroplast part namespace: cellular_component def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "host chloroplast component" EXACT [] is_a: GO:0033652 ! host cell chloroplast [Term] id: GO:0033654 name: host cell chloroplast thylakoid membrane namespace: cellular_component def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033653 ! host cell chloroplast part is_a: GO:0044160 ! host thylakoid membrane [Term] id: GO:0033655 name: host cell cytoplasm part namespace: cellular_component def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytoplasm component" BROAD [] is_a: GO:0033646 ! host intracellular part relationship: part_of GO:0030430 ! host cell cytoplasm [Term] id: GO:0033656 name: modification by symbiont of host chloroplast namespace: biological_process def: "The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0033657 name: modification by symbiont of host chloroplast part namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033656 ! modification by symbiont of host chloroplast [Term] id: GO:0033658 name: modification by symbiont of host chloroplast thylakoid namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033657 ! modification by symbiont of host chloroplast part [Term] id: GO:0033659 name: modification by symbiont of host mitochondrion namespace: biological_process def: "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0033660 name: suppression by symbiont of host resistance gene-dependent defense response namespace: biological_process def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT [] synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT [] synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW [] synonym: "negative regulation by symbiont of host resistance gene-dependent defense response" EXACT [] synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response [Term] id: GO:0033661 name: suppression by symbiont of defense-related host reactive oxygen species production namespace: biological_process def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the production of reactive oxygen species as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "down regulation by organism of defense-related host metabolic burst" EXACT [] synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT [] synonym: "downregulation by organism of defense-related host AOS production" EXACT [] synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW [] synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT [] synonym: "negative regulation by organism of defense-related host ROI production" EXACT [] synonym: "negative regulation by organism of defense-related host ROS production" EXACT [] synonym: "negative regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production [Term] id: GO:0033662 name: modulation by symbiont of host defense-related protein level namespace: biological_process def: "The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0075344 ! modulation by symbiont of host protein levels [Term] id: GO:0033663 name: negative regulation by symbiont of host defense-related protein level namespace: biological_process def: "Any process in which the symbiont reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level is_a: GO:0044414 ! suppression of host defenses by symbiont [Term] id: GO:0033664 name: positive regulation by symbiont of host defense-related protein level namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level is_a: GO:0044416 ! induction by symbiont of host defense response [Term] id: GO:0033665 name: obsolete regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'regulation of development of symbiont in host ; GO:0044127' and 'regulation of growth of symbiont in host ; GO:0044126'. synonym: "modulation of growth or development of organism within host" EXACT [] synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb] synonym: "modulation of invasive growth" BROAD [] synonym: "regulation of growth or development of symbiont in host" EXACT [] synonym: "regulation of growth or development of symbiont within host" EXACT [] is_obsolete: true consider: GO:0044127 [Term] id: GO:0033666 name: obsolete positive regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont in host ; GO:0044129' and 'positive regulation of growth of symbiont in host ; GO:0044128'. synonym: "positive regulation of growth or development of symbiont in host" EXACT [] synonym: "positive regulation of growth or development of symbiont within host" EXACT [] synonym: "positive regulation of invasive growth" BROAD [] synonym: "up regulation of growth or development of organism within host" EXACT [] synonym: "up-regulation of growth or development of organism within host" EXACT [] synonym: "upregulation of growth or development of organism within host" EXACT [] is_obsolete: true consider: GO:0044129 [Term] id: GO:0033667 name: obsolete negative regulation of growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont in host ; GO:0044131' and 'negative regulation of growth of symbiont in host ; GO:0044130'. synonym: "down regulation of growth or development of organism within host" EXACT [] synonym: "down-regulation of growth or development of organism within host" EXACT [] synonym: "downregulation of growth or development of organism within host" EXACT [] synonym: "inhibition of growth of development of organism within host" NARROW [] synonym: "negative regulation of growth or development of symbiont in host" EXACT [] synonym: "negative regulation of growth or development of symbiont within host" EXACT [] synonym: "negative regulation of invasive growth" BROAD [] is_obsolete: true consider: GO:0044131 [Term] id: GO:0033668 name: negative regulation by symbiont of host apoptotic process namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW [] synonym: "negative regulation by symbiont of host apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptotic process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: negatively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0033670 name: regulation of NAD+ kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "NAD kinase regulator" NARROW [] synonym: "regulation of NAD kinase activity" EXACT [] is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003951 ! NAD+ kinase activity relationship: regulates GO:0003951 ! NAD+ kinase activity [Term] id: GO:0033671 name: negative regulation of NAD+ kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "down regulation of NAD+ kinase activity" EXACT [] synonym: "down-regulation of NAD+ kinase activity" EXACT [] synonym: "downregulation of NAD+ kinase activity" EXACT [] synonym: "inhibition of NAD+ kinase activity" NARROW [] synonym: "NAD+ kinase inhibitor" NARROW [] is_a: GO:0033670 ! regulation of NAD+ kinase activity is_a: GO:0033673 ! negative regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003951 ! NAD+ kinase activity relationship: negatively_regulates GO:0003951 ! NAD+ kinase activity [Term] id: GO:0033672 name: positive regulation of NAD+ kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] synonym: "NAD+ kinase activator" NARROW [] synonym: "stimulation of NAD+ kinase activity" NARROW [] synonym: "up regulation of NAD+ kinase activity" EXACT [] synonym: "up-regulation of NAD+ kinase activity" EXACT [] synonym: "upregulation of NAD+ kinase activity" EXACT [] is_a: GO:0033670 ! regulation of NAD+ kinase activity is_a: GO:0033674 ! positive regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003951 ! NAD+ kinase activity relationship: positively_regulates GO:0003951 ! NAD+ kinase activity [Term] id: GO:0033673 name: negative regulation of kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "down regulation of kinase activity" EXACT [] synonym: "down-regulation of kinase activity" EXACT [] synonym: "downregulation of kinase activity" EXACT [] synonym: "inhibition of kinase activity" NARROW [] synonym: "kinase inhibitor" NARROW [] is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051348 ! negative regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016301 ! kinase activity relationship: negatively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033674 name: positive regulation of kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] synonym: "kinase activator" NARROW [] synonym: "stimulation of kinase activity" NARROW [] synonym: "up regulation of kinase activity" EXACT [] synonym: "up-regulation of kinase activity" EXACT [] synonym: "upregulation of kinase activity" EXACT [] is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0043549 ! regulation of kinase activity is_a: GO:0051347 ! positive regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016301 ! kinase activity relationship: positively_regulates GO:0016301 ! kinase activity [Term] id: GO:0033675 name: pericanalicular vesicle namespace: cellular_component def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033677 name: DNA/RNA helicase activity namespace: molecular_function alt_id: GO:0033680 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah] synonym: "ATP-dependent DNA/RNA helicase activity" EXACT [] is_a: GO:0004386 ! helicase activity is_a: GO:0140097 ! catalytic activity, acting on DNA is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0033678 name: 5'-3' DNA/RNA helicase activity namespace: molecular_function alt_id: GO:0033682 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' DNA/RNA helicase activity" EXACT [] is_a: GO:0033677 ! DNA/RNA helicase activity [Term] id: GO:0033679 name: 3'-5' DNA/RNA helicase activity namespace: molecular_function alt_id: GO:0033681 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] synonym: "3' to 5' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 3'-5' DNA/RNA helicase activity" EXACT [] is_a: GO:0033677 ! DNA/RNA helicase activity [Term] id: GO:0033683 name: nucleotide-excision repair, DNA incision namespace: biological_process def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896] synonym: "DNA incision involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] synonym: "nucleic acid cleavage involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis intersection_of: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis intersection_of: part_of GO:0006289 ! nucleotide-excision repair relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0033684 name: regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] is_a: GO:0032276 ! regulation of gonadotropin secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032275 ! luteinizing hormone secretion relationship: regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033685 name: negative regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "down regulation of luteinizing hormone secretion" EXACT [] synonym: "down-regulation of luteinizing hormone secretion" EXACT [] synonym: "downregulation of luteinizing hormone secretion" EXACT [] synonym: "inhibition of luteinizing hormone secretion" NARROW [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032275 ! luteinizing hormone secretion relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033686 name: positive regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "activation of luteinizing hormone secretion" NARROW [] synonym: "stimulation of luteinizing hormone secretion" NARROW [] synonym: "up regulation of luteinizing hormone secretion" EXACT [] synonym: "up-regulation of luteinizing hormone secretion" EXACT [] synonym: "upregulation of luteinizing hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032275 ! luteinizing hormone secretion relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion [Term] id: GO:0033687 name: osteoblast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0033688 name: regulation of osteoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033687 ! osteoblast proliferation relationship: regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033689 name: negative regulation of osteoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "down regulation of osteoblast proliferation" EXACT [] synonym: "down-regulation of osteoblast proliferation" EXACT [] synonym: "downregulation of osteoblast proliferation" EXACT [] synonym: "inhibition of osteoblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033687 ! osteoblast proliferation relationship: negatively_regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033690 name: positive regulation of osteoblast proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah] synonym: "activation of osteoblast proliferation" NARROW [] synonym: "stimulation of osteoblast proliferation" NARROW [] synonym: "up regulation of osteoblast proliferation" EXACT [] synonym: "up-regulation of osteoblast proliferation" EXACT [] synonym: "upregulation of osteoblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0033688 ! regulation of osteoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033687 ! osteoblast proliferation relationship: positively_regulates GO:0033687 ! osteoblast proliferation [Term] id: GO:0033691 name: sialic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [GOC:add, ISBN:9780721601465] synonym: "N-acetylneuraminic acid binding" NARROW [] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0033692 name: cellular polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [GOC:go_curators] synonym: "cellular glycan biosynthesis" EXACT [] synonym: "cellular glycan biosynthetic process" EXACT [] synonym: "cellular polysaccharide anabolism" EXACT [] synonym: "cellular polysaccharide biosynthesis" EXACT [] synonym: "cellular polysaccharide formation" EXACT [] synonym: "cellular polysaccharide synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0033693 name: neurofilament bundle assembly namespace: biological_process def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295] synonym: "NF bundle assembly" EXACT [] is_a: GO:0045110 ! intermediate filament bundle assembly [Term] id: GO:0033694 name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] xref: EC:1.5.7 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0033695 name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah] xref: EC:1.17.5 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033696 name: negative regulation of extent of heterochromatin assembly namespace: biological_process def: "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatin boundaries" RELATED [] synonym: "negative regulation of extent of heterochromatin formation" EXACT [] synonym: "negative regulation of heterochromatin spreading" RELATED [] is_a: GO:0031452 ! negative regulation of heterochromatin assembly is_a: GO:0031454 ! regulation of extent of heterochromatin assembly [Term] id: GO:0033697 name: positive regulation of extent of heterochromatin assembly namespace: biological_process def: "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah] synonym: "positive regulation of extent of heterochromatin formation" EXACT [] synonym: "positive regulation of heterochromatin spreading" RELATED [] is_a: GO:0031453 ! positive regulation of heterochromatin assembly is_a: GO:0031454 ! regulation of extent of heterochromatin assembly [Term] id: GO:0033698 name: Rpd3L complex namespace: cellular_component alt_id: GO:0000508 def: "A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae)." [GOC:vw, PMID:17450151] synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw] synonym: "Clr6L complex" EXACT [PMID:19040720] synonym: "Rpd3C(L)" EXACT [] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0033699 name: DNA 5'-adenosine monophosphate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] synonym: "AMP-removal activity" RELATED [] synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] synonym: "DNA adenylate hydrolysis activity" BROAD [] synonym: "DNA de-adenylation" RELATED [] synonym: "DNA deadenylation" RELATED [] is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0033700 name: phospholipid efflux namespace: biological_process def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah] synonym: "phospholipid export" EXACT [] is_a: GO:0015914 ! phospholipid transport [Term] id: GO:0033701 name: dTDP-galactose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186] synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186] synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186] synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186] xref: EC:1.1.1.186 xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN xref: RHEA:12396 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033702 name: (+)-trans-carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH." [EC:1.1.1.275, RHEA:14825] synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275] xref: EC:1.1.1.275 xref: KEGG_REACTION:R06117 xref: MetaCyc:RXN-9397 xref: RHEA:14825 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033703 name: 3beta-hydroxy-5beta-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH." [EC:1.1.1.277, RHEA:22944] synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277] synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277] xref: EC:1.1.1.277 xref: KEGG_REACTION:R06166 xref: MetaCyc:1.1.1.277-RXN xref: RHEA:22944 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033704 name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH." [EC:1.1.1.278, RHEA:18137] synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278] xref: EC:1.1.1.278 xref: KEGG_REACTION:R07138 xref: MetaCyc:1.1.1.278-RXN xref: RHEA:18137 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033705 name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281] comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281] synonym: "Rmd" RELATED [EC:1.1.1.281] xref: EC:1.1.1.281 xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033706 name: obsolete quinate/shikimate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282] comment: This term was made obsolete because it represents four reactions, and should be four separate terms. synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282] synonym: "quinate/shikimate dehydrogenase activity" EXACT [] synonym: "YdiB" RELATED [EC:1.1.1.282] is_obsolete: true consider: GO:0004764 consider: GO:0030266 consider: GO:0052733 consider: GO:0052734 [Term] id: GO:0033707 name: 3''-deamino-3''-oxonicotianamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285] synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285] xref: EC:1.1.1.285 xref: MetaCyc:1.1.1.285-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033708 name: isocitrate-homoisocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286] synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286] synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286] synonym: "PH1722" RELATED [EC:1.1.1.286] xref: EC:1.1.1.286 xref: MetaCyc:RXN-7969 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033709 name: D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287] synonym: "ARD1p" RELATED [EC:1.1.1.287] synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] xref: KEGG_REACTION:R07144 xref: MetaCyc:RXN-7972 xref: RHEA:11868 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033711 name: 4-phosphoerythronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH." [EC:1.1.1.290, RHEA:18829] synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290] synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290] synonym: "PdxB" RELATED [EC:1.1.1.290] synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290] xref: EC:1.1.1.290 xref: KEGG_REACTION:R04210 xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN xref: RHEA:18829 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033712 name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.292, RHEA:24208] synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292] synonym: "AFR" RELATED [EC:1.1.1.292] xref: EC:1.1.1.292 xref: KEGG_REACTION:R08194 xref: MetaCyc:1.1.1.292-RXN xref: RHEA:24208 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033713 name: choline:oxygen 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide." [EC:1.1.3.17] synonym: "choline oxidase activity" BROAD [EC:1.1.3.17] xref: EC:1.1.3.17 xref: MetaCyc:CHOLINE-OXIDASE-RXN xref: RHEA:24646 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033714 name: secondary-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + secondary alcohol = H(2)O(2) + ketone." [EC:1.1.3.18, RHEA:23180] synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18] synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18] xref: EC:1.1.3.18 xref: KEGG_REACTION:R02277 xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN xref: RHEA:23180 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033715 name: nucleoside oxidase activity namespace: molecular_function def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28] synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28] xref: EC:1.1.3.28 xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN xref: RHEA:24648 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033716 name: nucleoside oxidase (hydrogen peroxide-forming) activity namespace: molecular_function def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide; (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide." [EC:1.1.3.39] synonym: "nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity" EXACT [EC:1.1.3.39] xref: EC:1.1.3.39 xref: MetaCyc:1.1.3.39-RXN xref: RHEA:24656 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0033717 name: gluconate 2-dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3] synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3] synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3] synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3] synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3] xref: EC:1.1.99.3 xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN xref: RHEA:12769 is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0033718 name: pyranose dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29] synonym: "PDH" RELATED [EC:1.1.99.29] synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29] synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] xref: EC:1.1.99.29 xref: MetaCyc:RXN-7961 xref: MetaCyc:RXN-7962 xref: MetaCyc:RXN-7963 xref: MetaCyc:RXN-7965 xref: MetaCyc:RXN-7966 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033719 name: 2-oxo-acid reductase activity namespace: molecular_function def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30] synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30] synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30] synonym: "HVOR" RELATED [EC:1.1.99.30] xref: EC:1.1.99.30 xref: MetaCyc:1.1.99.30-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033720 name: (S)-mandelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31] synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31] synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31] synonym: "MDH" RELATED [EC:1.1.99.31] xref: EC:1.1.99.31 xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN xref: MetaCyc:MANDELATE-OXY-RXN xref: RHEA:15749 xref: UM-BBD_reactionID:r1048 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033721 name: aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4] synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4] synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] xref: EC:1.2.1.4 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: RHEA:11888 is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0033722 name: malonate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15] synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15] synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15] xref: EC:1.2.1.15 xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0033723 name: fluoroacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69] synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69] xref: EC:1.2.1.69 xref: RHEA:16677 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0033726 name: aldehyde ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5] synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] synonym: "AOR" RELATED [EC:1.2.7.5] synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] xref: EC:1.2.7.5 xref: MetaCyc:1.2.7.5-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0033727 name: aldehyde dehydrogenase (FAD-independent) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7] synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7] synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7] synonym: "AORDd" RELATED [EC:1.2.99.7] synonym: "Mop" RELATED [EC:1.2.99.7] xref: EC:1.2.99.7 xref: MetaCyc:1.2.99.3-RXN xref: MetaCyc:1.2.99.7-RXN xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0033728 name: divinyl chlorophyllide a 8-vinyl-reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75] synonym: "4VCR" RELATED [EC:1.3.1.75] synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75] synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75] xref: EC:1.3.1.75 xref: MetaCyc:RXN-5286 xref: RHEA:14449 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033729 name: anthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77] synonym: "ANR" RELATED [EC:1.3.1.77] synonym: "AtANR" RELATED [EC:1.3.1.77] synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77] synonym: "MtANR" RELATED [EC:1.3.1.77] xref: EC:1.3.1.77 xref: MetaCyc:1.3.1.77-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033730 name: arogenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78] synonym: "TyrAa" RELATED [EC:1.3.1.78] synonym: "TyrAAT1" RELATED [EC:1.3.1.78] synonym: "TyrAAT2" RELATED [EC:1.3.1.78] xref: EC:1.3.1.78 xref: MetaCyc:1.3.1.78-RXN xref: RHEA:15417 is_a: GO:0033731 ! arogenate dehydrogenase [NAD(P)+] activity [Term] id: GO:0033731 name: arogenate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79] synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79] synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79] synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79] xref: EC:1.3.1.79 xref: MetaCyc:1.3.1.79-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0033732 name: pyrroloquinoline-quinone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone." [EC:1.3.3.11, RHEA:10692] synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11] synonym: "PqqC" RELATED [EC:1.3.3.11] xref: EC:1.3.3.11 xref: KEGG_REACTION:R07353 xref: MetaCyc:1.3.3.11-RXN xref: RHEA:10692 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0033734 name: (R)-benzylsuccinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.8.3] synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.8.3] synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.8.3] synonym: "BbsG" RELATED [EC:1.3.8.3] xref: EC:1.3.8.3 xref: RHEA:20876 xref: UM-BBD_reactionID:r0330 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0033735 name: aspartate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21] synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21] synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] xref: EC:1.4.1.21 xref: KEGG_REACTION:R07164 xref: KEGG_REACTION:R07165 xref: MetaCyc:1.4.1.21-RXN xref: RHEA:11784 xref: RHEA:11788 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0033736 name: L-lysine 6-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+)." [EC:1.4.3.20, RHEA:22548] synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20] synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20] synonym: "Lod" RELATED [EC:1.4.3.20] synonym: "LodA" RELATED [EC:1.4.3.20] synonym: "marinocine" RELATED [EC:1.4.3.20] xref: EC:1.4.3.20 xref: KEGG_REACTION:R07598 xref: MetaCyc:1.4.3.20-RXN xref: RHEA:22548 is_a: GO:0001716 ! L-amino-acid oxidase activity [Term] id: GO:0033737 name: 1-pyrroline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [MetaCyc:1.5.1.35-RXN] synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35] synonym: "ABALDH" RELATED [EC:1.5.1.35] synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35] synonym: "YdcW" RELATED [EC:1.5.1.35] xref: EC:1.2.1.19 xref: MetaCyc:1.5.1.35-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0033738 name: methylenetetrahydrofolate reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1] xref: EC:1.5.7.1 xref: MetaCyc:RXN-5061 is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0033739 name: preQ1 synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH." [EC:1.7.1.13, RHEA:13409] synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.7.1.13] synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13] synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13] synonym: "QueF" RELATED [EC:1.7.1.13] synonym: "queuine synthase activity" RELATED [] synonym: "queuine:NADP+ oxidoreductase activity" RELATED [] synonym: "YkvM" RELATED [EC:1.7.1.13] xref: EC:1.7.1.13 xref: KEGG_REACTION:R07605 xref: MetaCyc:RXN0-4022 xref: RHEA:13409 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0033740 name: hydroxylamine oxidoreductase activity namespace: molecular_function def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.2.8] synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.2.8] xref: EC:1.7.2.8 xref: MetaCyc:1.7.99.8-RXN xref: RHEA:23232 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0033741 name: adenylyl-sulfate reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14141] synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9] xref: EC:1.8.4.9 xref: KEGG_REACTION:R05717 xref: MetaCyc:1.8.4.9-RXN xref: RHEA:14141 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033743 name: peptide-methionine (R)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0000318 def: "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164] synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12] synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12] synonym: "MsrB" RELATED [EC:1.8.4.12] synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12] synonym: "PilB" RELATED [EC:1.8.4.12] synonym: "pMRsr" RELATED [EC:1.8.4.12] synonym: "pMSR" RELATED [EC:1.8.4.12] synonym: "protein-methionine-R-oxide reductase activity" EXACT [] synonym: "selenoprotein R" RELATED [EC:1.8.4.12] synonym: "SelR" RELATED [EC:1.8.4.12] synonym: "SelX" RELATED [EC:1.8.4.12] xref: EC:1.8.4.12 xref: KEGG_REACTION:R07607 xref: MetaCyc:1.8.4.12-RXN xref: Reactome:R-HSA-5676917 "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine" xref: RHEA:24164 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033744 name: L-methionine:thioredoxin-disulfide S-oxidoreductase activity namespace: molecular_function alt_id: GO:0000317 def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13] synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13] synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13] synonym: "fSMsr" RELATED [EC:1.8.4.13] synonym: "L-methionine-(S)-S-oxide reductase activity" NARROW [GOC:bf, GOC:vw] synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13] synonym: "methionine-S-oxide reductase activity" EXACT [PMID:11169920] synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13] xref: EC:1.8.4.13 xref: KEGG_REACTION:R07606 xref: MetaCyc:1.8.4.13-RXN xref: RHEA:19993 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033745 name: L-methionine-(R)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14] synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14] synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14] synonym: "FRMsr" RELATED [EC:1.8.4.14] synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14] xref: EC:1.8.4.14 xref: MetaCyc:1.8.4.14-RXN xref: RHEA:21260 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0033746 name: histone demethylase activity (H3-R2 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0070078 ! histone H3-R2 demethylation [Term] id: GO:0033747 name: obsolete versatile peroxidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.16] synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16] synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16] synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16] synonym: "versatile peroxidase activity" EXACT [] synonym: "VP" RELATED [EC:1.11.1.16] is_obsolete: true replaced_by: GO:0004601 consider: GO:0052750 [Term] id: GO:0033748 name: hydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6] synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6] synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6] synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6] xref: EC:1.12.99.6 xref: MetaCyc:RXN0-4141 xref: MetaCyc:RXN0-5256 xref: RHEA:12116 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0033749 name: histone demethylase activity (H4-R3 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0070079 ! histone H4-R3 demethylation [Term] id: GO:0033750 name: ribosome localization namespace: biological_process alt_id: GO:0033753 def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "establishment of ribosome localisation" RELATED [] synonym: "establishment of ribosome localization" RELATED [] synonym: "ribosome localisation" RELATED [] is_a: GO:0008104 ! protein localization is_a: GO:0051640 ! organelle localization [Term] id: GO:0033751 name: linoleate 8R-lipoxygenase namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.60] synonym: "5,8-linoleate diol synthase (bifunctional enzyme)" RELATED [EC:1.13.11.60] synonym: "7,8-linoleate diol synthase (bifunctional enzyme)" RELATED [EC:1.13.11.60] synonym: "linoleate diol synthase activity" RELATED [] xref: EC:1.13.11.60 xref: RHEA:25395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033752 name: acetylacetone-cleaving enzyme activity namespace: molecular_function def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50] synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50] synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50] synonym: "Dke1" RELATED [EC:1.13.11.50] xref: EC:1.13.11.50 xref: RHEA:12877 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033754 name: indoleamine 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine." [EC:1.13.11.52] synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52] synonym: "IDO" RELATED [EC:1.13.11.52] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] xref: EC:1.13.11.52 xref: MetaCyc:RXN-8664 xref: MetaCyc:RXN-8665 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033755 name: sulfur oxygenase/reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55] synonym: "SOR" RELATED [EC:1.13.11.55] synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55] synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55] synonym: "sulphur oxygenase/reductase activity" EXACT [] xref: EC:1.13.11.55 xref: MetaCyc:1.13.11.55-RXN xref: RHEA:13957 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0033756 name: Oplophorus-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13] synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13] synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13] xref: EC:1.13.12.13 xref: MetaCyc:RXN-3361 xref: RHEA:20417 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0033757 name: glucoside 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13] synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13] synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] xref: EC:1.1.99.13 xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN xref: RHEA:16589 xref: Wikipedia:Glucoside_3-dehydrogenase is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0033758 name: clavaminate synthase activity namespace: molecular_function def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21] synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21] synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21] synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21] xref: EC:1.14.11.21 xref: MetaCyc:1.14.11.21-RXN is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0033759 name: flavone synthase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.20.5] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.20.5] synonym: "flavone synthase I activity" EXACT [EC:1.14.20.5] synonym: "FNS I" RELATED [EC:1.14.20.5] xref: EC:1.14.20.5 xref: MetaCyc:RXN-8000 xref: RHEA:10448 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity relationship: part_of GO:0051553 ! flavone biosynthetic process [Term] id: GO:0033760 name: 2'-deoxymugineic-acid 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate." [EC:1.14.11.24, RHEA:12200] synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24] synonym: "IDS3" RELATED [EC:1.14.11.24] xref: EC:1.14.11.24 xref: KEGG_REACTION:R07185 xref: MetaCyc:1.14.11.24-RXN xref: RHEA:12200 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0033761 name: mugineic-acid 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2." [EC:1.14.11.25] synonym: "IDS2" RELATED [EC:1.14.11.25] synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25] xref: EC:1.14.11.25 xref: KEGG_REACTION:R07186 xref: MetaCyc:RXN-7982 xref: RHEA:14509 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0033762 name: response to glucagon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] synonym: "response to glucagon stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0033763 name: proline 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28] synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28] synonym: "P-3-H" RELATED [EC:1.14.11.28] xref: EC:1.14.11.28 xref: MetaCyc:1.14.11.28-RXN xref: RHEA:20265 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0033764 name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah] is_a: GO:0016229 ! steroid dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033765 name: steroid dehydrogenase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah] xref: EC:1.1.1 is_a: GO:0016229 ! steroid dehydrogenase activity is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0033766 name: 2-hydroxyquinoline 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol." [EC:1.14.13.61, RHEA:22080] synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61] synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61] xref: EC:1.14.13.61 xref: KEGG_REACTION:R05158 xref: MetaCyc:1.14.13.61-RXN xref: RHEA:22080 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033767 name: 4-hydroxyacetophenone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4'-hydroxyacetophenone + H(+) + NADPH + O(2) = 4-hydroxyphenyl acetate + H(2)O + NADP(+)." [EC:1.14.13.84, RHEA:22916] synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT systematic_synonym [EC:1.14.13.84] synonym: "HAPMO" RELATED [EC:1.14.13.84] xref: EC:1.14.13.84 xref: KEGG_REACTION:R06892 xref: MetaCyc:1.14.13.84-RXN xref: RHEA:22916 xref: UM-BBD_reactionID:r0756 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033768 name: SUMO-targeted ubiquitin ligase complex namespace: cellular_component def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0033769 name: glyceollin synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85] synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85] synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85] xref: EC:1.14.13.85 xref: MetaCyc:2.5.1.36-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033770 name: 2-hydroxyisoflavanone synthase activity namespace: molecular_function def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86] synonym: "2-HIS" RELATED [EC:1.14.13.86] synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86] xref: EC:1.14.13.86 xref: MetaCyc:RXN-7750 xref: RHEA:14897 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033771 name: licodione synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+)." [EC:1.14.14.140, RHEA:15697] synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.14.140] synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.14.140] xref: EC:1.14.14.140 xref: KEGG_REACTION:R07198 xref: MetaCyc:1.14.13.87-RXN xref: RHEA:15697 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033772 name: flavonoid 3',5'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.14.81] synonym: "F3',5'H" RELATED [EC:1.14.14.81] synonym: "F3'5'H" RELATED [EC:1.14.14.81] synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.14.81] xref: EC:1.14.14.81 xref: MetaCyc:RXN-7783 xref: MetaCyc:RXN-8671 xref: RHEA:55448 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033773 name: isoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89] synonym: "CYP Ge-3" RELATED [EC:1.14.13.89] synonym: "CYP81E1" RELATED [EC:1.14.13.89] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89] synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89] xref: EC:1.14.13.89 xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033774 name: basal labyrinth namespace: cellular_component def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0033775 name: deoxysarpagine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine." [EC:1.14.14.136, RHEA:14237] synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.14.136] synonym: "DOSH" RELATED [EC:1.14.14.136] xref: EC:1.14.14.136 xref: KEGG_REACTION:R05828 xref: MetaCyc:1.14.13.91-RXN xref: RHEA:14237 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033776 name: phenylacetone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+)." [EC:1.14.13.92, RHEA:10124] synonym: "PAMO" RELATED [EC:1.14.13.92] synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92] xref: EC:1.14.13.92 xref: KEGG_REACTION:R07201 xref: MetaCyc:1.14.13.92-RXN xref: RHEA:10124 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033777 name: lithocholate 6beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.14.138, RHEA:18857] synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.14.138] synonym: "CYP3A10" RELATED [EC:1.14.14.138] synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.14.138] synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.14.138] synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.14.138] xref: EC:1.14.14.138 xref: KEGG_REACTION:R07203 xref: MetaCyc:1.14.13.94-RXN xref: RHEA:18857 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033778 name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)." [EC:1.14.13.95, RHEA:10504] synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95] synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95] synonym: "CYP12" RELATED [EC:1.14.13.95] synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95] xref: EC:1.14.13.95 xref: KEGG_REACTION:R04826 xref: MetaCyc:1.14.13.95-RXN xref: Reactome:R-HSA-192157 "CYP8B1 12-hydroxylates 4CHOL7aOLONE" xref: Reactome:R-HSA-193709 "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL" xref: Reactome:R-HSA-193845 "CYP8B1 12-hydroxylates 4CHOL7a,27DONE" xref: RHEA:10504 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033779 name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+)." [EC:1.14.14.139, RHEA:15261] synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.14.139] synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.14.139] synonym: "CYP8B1" RELATED [EC:1.14.14.139] synonym: "cytochrome P450 8B1" RELATED [EC:1.14.14.139] synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.14.139] xref: EC:1.14.14.139 xref: KEGG_REACTION:R07204 xref: MetaCyc:1.14.13.96-RXN xref: RHEA:15261 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033780 name: taurochenodeoxycholate 6alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] synonym: "CYP3A4" RELATED [EC:1.14.13.97] synonym: "CYP4A21" RELATED [EC:1.14.13.97] synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97] synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97] xref: EC:1.14.13.97 xref: MetaCyc:RXN-7977 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033781 name: cholesterol 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.14.25, RHEA:22716] synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.14.25] synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.14.25] synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.14.25] synonym: "CYP46" RELATED [EC:1.14.14.25] synonym: "CYP46A1" RELATED [EC:1.14.14.25] synonym: "cytochrome P450 46A1" RELATED [EC:1.14.14.25] xref: EC:1.14.14.25 xref: KEGG_REACTION:R07207 xref: MetaCyc:1.14.13.98-RXN xref: Reactome:R-HSA-192061 "CYP46A1 24-hydroxylates CHOL" xref: RHEA:22716 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033782 name: 24-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.99, RHEA:16093] synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99] synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99] synonym: "CYP39A1" RELATED [EC:1.14.13.99] synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99] xref: EC:1.14.13.99 xref: KEGG_REACTION:R07208 xref: MetaCyc:1.14.13.99-RXN xref: RHEA:16093 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033783 name: 25-hydroxycholesterol 7alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.14.29] synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.14.29] synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.14.29] synonym: "CYP7B1" RELATED [EC:1.14.14.29] synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.14.29] xref: EC:1.14.14.29 xref: MetaCyc:RXN-7980 xref: MetaCyc:RXN-7981 xref: RHEA:19041 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033784 name: senecionine N-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide." [EC:1.14.13.101, RHEA:11420] synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] synonym: "SNO" RELATED [EC:1.14.13.101] xref: EC:1.14.13.101 xref: KEGG_REACTION:R07373 xref: MetaCyc:1.14.13.101-RXN xref: RHEA:11420 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0033785 name: heptose 7-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341] synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT [] xref: EC:2.7.1 xref: IMG:02784 xref: MetaCyc:RXN0-4341 is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033786 name: heptose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342] synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT [] synonym: "heptose 1-phosphate adenyltransferase activity" EXACT [] xref: IMG:02786 xref: MetaCyc:RXN0-4342 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0033787 name: cyanocobalamin reductase (cyanide-eliminating) activity namespace: molecular_function def: "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH." [EC:1.16.1.6, RHEA:16113] synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6] synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] xref: EC:1.16.1.6 xref: KEGG_REACTION:R02999 xref: MetaCyc:1.6.99.12-RXN xref: Reactome:R-HSA-3149519 "MMACHC decyanates CNCbl" xref: RHEA:16113 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0033788 name: leucoanthocyanidin reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3] synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3] synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3] xref: EC:1.17.1.3 xref: MetaCyc:RXN-1484 xref: RHEA:10616 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0033789 name: phenylacetyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA." [EC:1.17.5.1, RHEA:15705] synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1] synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1] xref: EC:1.17.5.1 xref: KEGG_REACTION:R07222 xref: MetaCyc:1.17.5.1-RXN xref: RHEA:15705 is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [Term] id: GO:0033790 name: hydroxymethylfurfural reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033791 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3] synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3] synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] xref: EC:1.17.99.3 xref: MetaCyc:1.17.99.3-RXN xref: RHEA:15733 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033792 name: bile-acid 7alpha-dehydroxylase activity namespace: molecular_function def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2, and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5] synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5] synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5] xref: EC:1.17.99.5 xref: MetaCyc:RXN-8658 xref: MetaCyc:RXN-8659 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0033793 name: aureusidin synthase activity namespace: molecular_function def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6] synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6] is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0033794 name: sarcosine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3] synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3] xref: EC:1.21.4.3 xref: RHEA:12825 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0033795 name: betaine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4] synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4] xref: EC:1.21.4.4 xref: RHEA:11848 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0033796 name: sulfur reductase activity namespace: molecular_function def: "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.12.98.4] synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.12.98.4] synonym: "sulphur reductase activity" EXACT [] xref: EC:1.12.98.4 xref: MetaCyc:1.97.1.3-RXN xref: MetaCyc:RXN-8269 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033797 name: selenate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite." [EC:1.97.1.9, RHEA:14031] synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9] xref: EC:1.97.1.9 xref: KEGG_REACTION:R07229 xref: MetaCyc:RXN0-2101 xref: RHEA:14031 xref: UM-BBD_reactionID:r0828 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033798 name: thyroxine 5-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.21.99.3] synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.21.99.3] synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.21.99.3] synonym: "inner ring-deiodinating pathway" EXACT [PMID:20403357] synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.21.99.3] synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.21.99.3] synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.21.99.3] xref: EC:1.21.99.3 xref: MetaCyc:1.97.1.11-RXN xref: RHEA:18897 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0033799 name: myricetin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451] comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149. synonym: "CrCOMT2" RELATED [EC:2.1.1.149] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149] synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149] xref: EC:2.1.1.149 xref: KEGG_REACTION:R06815 xref: MetaCyc:RXN-8451 xref: RHEA:24280 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033800 name: isoflavone 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150] synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150] xref: EC:2.1.1.150 xref: MetaCyc:RXN-6241 xref: RHEA:17933 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033801 name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153] synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153] xref: EC:2.1.1.153 xref: MetaCyc:RXN-4981 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033802 name: isoliquiritigenin 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.154, RHEA:21608] synonym: "chalcone OMT" RELATED [EC:2.1.1.154] synonym: "CHMT" RELATED [EC:2.1.1.154] synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154] xref: EC:2.1.1.154 xref: KEGG_REACTION:R07242 xref: MetaCyc:RXN-3501 xref: RHEA:21608 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033803 name: kaempferol 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide." [EC:2.1.1.155, RHEA:15105] synonym: "F 4'-OMT" RELATED [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] xref: EC:2.1.1.155 xref: KEGG_REACTION:R06807 xref: MetaCyc:2.1.1.155-RXN xref: RHEA:15105 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0033804 name: obsolete glycine/sarcosine N-methyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "ApGSMT" RELATED [EC:2.1.1.156] synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156] synonym: "glycine/sarcosine N-methyltransferase activity" EXACT [] synonym: "GMT" RELATED [EC:2.1.1.156] synonym: "GSMT" RELATED [EC:2.1.1.156] synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] is_obsolete: true consider: GO:0017174 consider: GO:0052730 [Term] id: GO:0033805 name: obsolete sarcosine/dimethylglycine N-methyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "ApDMT" RELATED [EC:2.1.1.157] synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157] synonym: "sarcosine dimethylglycine methyltransferase activity" NARROW [EC:2.1.1.157] synonym: "sarcosine dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157] synonym: "sarcosine/dimethylglycine N-methyltransferase activity" EXACT [] synonym: "SDMT" RELATED [EC:2.1.1.157] is_obsolete: true consider: GO:0052729 consider: GO:0052730 [Term] id: GO:0033806 name: fluorothreonine transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8] synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8] xref: EC:2.2.1.8 xref: RHEA:11748 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0033807 name: icosanoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119] synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119] synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119] xref: EC:2.3.1.119 xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033808 name: 6'-deoxychalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170] xref: EC:2.3.1.170 xref: MetaCyc:RXN-3142 xref: RHEA:10584 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033809 name: anthocyanin 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171] synonym: "3MaT" RELATED [EC:2.3.1.171] synonym: "Dv3MaT" RELATED [EC:2.3.1.171] synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] xref: EC:2.3.1.171 xref: MetaCyc:2.3.1.171-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033810 name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172] synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172] synonym: "Ss5MaT1" RELATED [EC:2.3.1.172] xref: EC:2.3.1.172 xref: MetaCyc:2.3.1.172-RXN xref: RHEA:21988 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033811 name: flavonol-3-O-triglucoside O-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173] synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173] xref: EC:2.3.1.173 xref: MetaCyc:2.3.1.173-RXN xref: RHEA:22160 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033812 name: 3-oxoadipyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174] synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174] xref: EC:2.3.1.174 xref: MetaCyc:RXN-3641 xref: RHEA:19481 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033813 name: deacetylcephalosporin-C acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA." [EC:2.3.1.175, RHEA:23860] synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "cefG" RELATED [EC:2.3.1.175] synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175] synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175] synonym: "DAC-AT" RELATED [EC:2.3.1.175] synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175] xref: EC:2.3.1.175 xref: KEGG_REACTION:R03064 xref: MetaCyc:2.3.1.175-RXN xref: RHEA:23860 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0033814 name: propanoyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176] synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176] synonym: "PTE-2" RELATED [EC:2.3.1.176] synonym: "SCP-X" RELATED [EC:2.3.1.176] synonym: "SCPchi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176] xref: EC:2.3.1.176 xref: MetaCyc:2.3.1.176-RXN xref: RHEA:16865 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0033815 name: biphenyl synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177] synonym: "BIS" RELATED [EC:2.3.1.177] synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177] xref: EC:2.3.1.177 xref: MetaCyc:2.3.1.177-RXN xref: RHEA:22292 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033816 name: diaminobutyrate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+)." [EC:2.3.1.178, RHEA:16901] synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "DABAcT" RELATED [EC:2.3.1.178] synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "EctA" RELATED [EC:2.3.1.178] synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178] xref: EC:2.3.1.178 xref: KEGG_REACTION:R06978 xref: MetaCyc:R102-RXN xref: RHEA:16901 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0033817 name: beta-ketoacyl-acyl-carrier-protein synthase II activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.179] synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179] synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179] synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179] synonym: "FabF" RELATED [EC:2.3.1.179] synonym: "KAS II" RELATED [EC:2.3.1.179] synonym: "KASII" RELATED [EC:2.3.1.179] xref: EC:2.3.1.179 xref: MetaCyc:2.3.1.179-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033818 name: beta-ketoacyl-acyl-carrier-protein synthase III activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.180] synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180] synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] synonym: "FabH" RELATED [EC:2.3.1.180] synonym: "KAS III" RELATED [EC:2.3.1.180] synonym: "KASIII" RELATED [EC:2.3.1.180] xref: EC:2.3.1.180 xref: MetaCyc:2.3.1.180-RXN xref: RHEA:12080 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033819 name: lipoyl(octanoyl) transferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181] synonym: "LipB" RELATED [EC:2.3.1.181] synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181] synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] xref: EC:2.3.1.181 xref: MetaCyc:RXN0-947 xref: Reactome:R-HSA-6793590 "LIPT2 transfers octanoyl group to GCSH" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0033820 name: DNA alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26] synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] xref: EC:2.4.1.26 xref: MetaCyc:2.4.1.26-RXN is_a: GO:0046527 ! glucosyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0033821 name: DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27] synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] xref: EC:2.4.1.27 xref: MetaCyc:2.4.1.27-RXN is_a: GO:0046527 ! glucosyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0033822 name: glucosyl-DNA beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28] synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28] xref: EC:2.4.1.28 xref: MetaCyc:2.4.1.28-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033823 name: procollagen glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66] synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] xref: EC:2.4.1.66 xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1981157 "Glucosylation of collagen propeptide hydroxylysines" is_a: GO:0046527 ! glucosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0033824 name: alternansucrase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140] synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140] xref: EC:2.4.1.140 xref: MetaCyc:2.4.1.140-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033825 name: oligosaccharide 4-alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161] synonym: "amylase III activity" EXACT [EC:2.4.1.161] xref: EC:2.4.1.161 xref: MetaCyc:2.4.1.161-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033826 name: xyloglucan 4-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168] synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168] xref: EC:2.4.1.168 xref: MetaCyc:2.4.1.168-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033827 name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197] synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] xref: EC:2.4.1.197 xref: MetaCyc:2.4.1.197-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0033828 name: glucosylglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+)." [EC:2.4.1.213, RHEA:12881] synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213] synonym: "GGPS" RELATED [EC:2.4.1.213] synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213] xref: EC:2.4.1.213 xref: KEGG_REACTION:R05328 xref: MetaCyc:2.4.1.213-RXN xref: RHEA:12881 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033829 name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222] synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222] xref: EC:2.4.1.222 xref: MetaCyc:2.4.1.222-RXN xref: Reactome:R-HSA-1912355 "Glycosylation of Pre-NOTCH by FRINGE" xref: Reactome:R-HSA-5096538 "Defective LFNG does not transfer GlcNAc to Pre-NOTCH" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0033830 name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229] synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] xref: EC:2.4.1.229 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0033831 name: kojibiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.230, RHEA:11176] synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230] xref: EC:2.4.1.230 xref: KEGG_REACTION:R07264 xref: MetaCyc:2.4.1.230-RXN xref: RHEA:11176 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033832 name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231] synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231] synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] xref: MetaCyc:RXN-4441 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033833 name: hydroxymethylfurfural reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] xref: MetaCyc:RXN-10738 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033834 name: kaempferol 3-O-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234] synonym: "F3GalTase activity" EXACT [EC:2.4.1.234] synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234] xref: EC:2.4.1.234 xref: MetaCyc:2.4.1.234-RXN is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0033835 name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236] synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] xref: EC:2.4.1.236 xref: MetaCyc:RXN-5001 xref: MetaCyc:RXN-5002 xref: MetaCyc:RXN-5004 xref: MetaCyc:RXN-7759 xref: MetaCyc:RXN-9699 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0033836 name: flavonol 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237] synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237] xref: EC:2.4.1.237 xref: MetaCyc:2.4.1.237-RXN xref: RHEA:23164 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033837 name: anthocyanin 3'-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238] synonym: "3'GT" RELATED [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238] synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238] xref: EC:2.4.1.238 xref: MetaCyc:2.4.1.238-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033838 name: flavonol-3-O-glucoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239] synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239] xref: EC:2.4.1.239 xref: MetaCyc:2.4.1.239-RXN xref: RHEA:18893 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033839 name: flavonol-3-O-glycoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240] synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240] xref: EC:2.4.1.240 xref: MetaCyc:2.4.1.240-RXN xref: RHEA:23544 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033840 name: NDP-glucose-starch glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242] synonym: "GBSS" RELATED [EC:2.4.1.242] synonym: "GBSSI" RELATED [EC:2.4.1.242] synonym: "GBSSII" RELATED [EC:2.4.1.242] synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242] synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] synonym: "starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "waxy protein" RELATED [EC:2.4.1.242] xref: EC:2.4.1.242 xref: MetaCyc:2.4.1.242-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0033841 name: 6G-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243] synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FFT" RELATED [EC:2.4.1.243] synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243] synonym: "6G-FT" RELATED [EC:2.4.1.243] synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243] xref: EC:2.4.1.243 xref: MetaCyc:2.4.1.243-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0033842 name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244] synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244] synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244] synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] xref: EC:2.4.1.244 xref: MetaCyc:2.4.1.244-RXN xref: RHEA:20493 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0033843 name: xyloglucan 6-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39] synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39] synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] xref: EC:2.4.2.39 xref: MetaCyc:2.4.2.39-RXN is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0033844 name: galactose-6-sulfurylase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5] synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5] synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5] synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5] xref: EC:2.5.1.5 xref: MetaCyc:2.5.1.5-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033845 name: hydroxymethylfurfural reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033846 name: adenosyl-fluoride synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63] synonym: "fluorinase activity" EXACT [EC:2.5.1.63] synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63] xref: EC:2.5.1.63 xref: MetaCyc:2.5.1.63-RXN xref: RHEA:16661 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033847 name: O-phosphoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65] synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65] synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65] xref: EC:2.5.1.65 xref: MetaCyc:2.5.1.65-RXN xref: RHEA:10252 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033848 name: N2-(2-carboxyethyl)arginine synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate." [EC:2.5.1.66, RHEA:10556] synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66] synonym: "CEAS" RELATED [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66] xref: EC:2.5.1.66 xref: KEGG_REACTION:R05465 xref: MetaCyc:2.5.1.66-RXN xref: RHEA:10556 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033849 name: chrysanthemyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate." [EC:2.5.1.67, RHEA:14009] synonym: "CPPase activity" EXACT [EC:2.5.1.67] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67] xref: EC:2.5.1.67 xref: KEGG_REACTION:R08948 xref: MetaCyc:2.5.1.67-RXN xref: RHEA:14009 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033850 name: Z-farnesyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.68, RHEA:23300] synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68] xref: EC:2.5.1.68 xref: KEGG_REACTION:R08528 xref: MetaCyc:2.5.1.68-RXN xref: RHEA:23300 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033851 name: lavandulyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69, RHEA:21676] synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69] synonym: "FDS-5" RELATED [EC:2.5.1.69] xref: EC:2.5.1.69 xref: KEGG_REACTION:R08950 xref: MetaCyc:2.5.1.69-RXN xref: RHEA:21676 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0033852 name: thyroid-hormone transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate." [EC:2.6.1.26, RHEA:19133] synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26] synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26] synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26] xref: EC:2.6.1.26 xref: KEGG_REACTION:R03952 xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN xref: RHEA:19133 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033853 name: aspartate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78] synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "PAT" RELATED [EC:2.6.1.78] synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78] xref: EC:2.6.1.78 xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN xref: RHEA:20445 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033854 name: glutamate-prephenate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate." [EC:2.6.1.79, RHEA:22880] synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79] synonym: "PAT" RELATED [EC:2.6.1.79] synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79] xref: EC:2.6.1.79 xref: KEGG_REACTION:R07276 xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN xref: RHEA:22880 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033855 name: nicotianamine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80, RHEA:22104] synonym: "NAAT" RELATED [EC:2.6.1.80] synonym: "NAAT-I" RELATED [EC:2.6.1.80] synonym: "NAAT-II" RELATED [EC:2.6.1.80] synonym: "NAAT-III" RELATED [EC:2.6.1.80] synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80] synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80] xref: EC:2.6.1.80 xref: KEGG_REACTION:R07277 xref: MetaCyc:2.6.1.80-RXN xref: RHEA:22104 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033856 name: pyridoxine 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate." [EC:2.6.99.2, RHEA:15265] synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2] synonym: "PdxJ" RELATED [EC:2.6.99.2] synonym: "PNP synthase activity" EXACT [EC:2.6.99.2] synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2] xref: EC:2.6.99.2 xref: KEGG_REACTION:R05838 xref: MetaCyc:PDXJ-RXN xref: RHEA:15265 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0033857 name: diphosphoinositol-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24] synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24] synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24] synonym: "PPIP5K" RELATED [EC:2.7.4.24] synonym: "PPIP5K1" RELATED [EC:2.7.4.24] synonym: "PPIP5K2" RELATED [EC:2.7.4.24] synonym: "VIP1" NARROW [EC:2.7.4.24] synonym: "VIP2" NARROW [EC:2.7.4.24] xref: EC:2.7.4.24 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0033858 name: N-acetylgalactosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157] synonym: "GALK2" RELATED [EC:2.7.1.157] synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157] synonym: "GK2" RELATED [EC:2.7.1.157] synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157] xref: EC:2.7.1.157 xref: MetaCyc:2.7.1.157-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033859 name: furaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0033860 name: regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016174 ! NAD(P)H oxidase activity relationship: regulates GO:0016174 ! NAD(P)H oxidase activity [Term] id: GO:0033861 name: negative regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah] synonym: "down regulation of NAD(P)H oxidase activity" EXACT [] synonym: "down-regulation of NAD(P)H oxidase activity" EXACT [] synonym: "downregulation of NAD(P)H oxidase activity" EXACT [] synonym: "inhibition of NAD(P)H oxidase activity" NARROW [] is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity is_a: GO:0051354 ! negative regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016174 ! NAD(P)H oxidase activity relationship: negatively_regulates GO:0016174 ! NAD(P)H oxidase activity [Term] id: GO:0033862 name: UMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22] synonym: "PyrH" RELATED [EC:2.7.4.22] synonym: "SmbA" RELATED [EC:2.7.4.22] synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22] synonym: "UMPK" RELATED [EC:2.7.4.22] synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22] xref: EC:2.7.4.22 xref: MetaCyc:2.7.4.22-RXN xref: RHEA:24400 is_a: GO:0009041 ! uridylate kinase activity [Term] id: GO:0033863 name: ribose 1,5-bisphosphate phosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+)." [EC:2.7.4.23, RHEA:20109] synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23] synonym: "PhnN" RELATED [EC:2.7.4.23] synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23] xref: EC:2.7.4.23 xref: KEGG_REACTION:R06836 xref: MetaCyc:2.7.4.23-RXN xref: RHEA:20109 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0033864 name: positive regulation of NAD(P)H oxidase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah] synonym: "activation of NAD(P)H oxidase activity" NARROW [] synonym: "stimulation of NAD(P)H oxidase activity" NARROW [] synonym: "up regulation of NAD(P)H oxidase activity" EXACT [] synonym: "up-regulation of NAD(P)H oxidase activity" EXACT [] synonym: "upregulation of NAD(P)H oxidase activity" EXACT [] is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016174 ! NAD(P)H oxidase activity relationship: positively_regulates GO:0016174 ! NAD(P)H oxidase activity [Term] id: GO:0033865 name: nucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "nucleoside bisphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0033866 name: nucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "nucleoside bisphosphate anabolism" EXACT [] synonym: "nucleoside bisphosphate biosynthesis" EXACT [] synonym: "nucleoside bisphosphate formation" EXACT [] synonym: "nucleoside bisphosphatehate synthesis" EXACT [] is_a: GO:0033865 ! nucleoside bisphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0033867 name: Fas-activated serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8] synonym: "FAST" RELATED [EC:2.7.11.8] synonym: "FASTK" RELATED [EC:2.7.11.8] synonym: "STK10" RELATED [EC:2.7.11.8] xref: EC:2.7.11.8 xref: MetaCyc:2.7.11.8-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0033868 name: obsolete Goodpasture-antigen-binding protein kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] comment: This term was made obsolete because it represents a specific gene product. synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9] synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9] synonym: "GPBPK" RELATED [EC:2.7.11.9] synonym: "STK11" RELATED [EC:2.7.11.9] xref: EC:2.7.11.9 xref: MetaCyc:2.7.11.9-RXN is_obsolete: true [Term] id: GO:0033869 name: nucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "nucleoside bisphosphate breakdown" EXACT [] synonym: "nucleoside bisphosphate catabolism" EXACT [] synonym: "nucleoside bisphosphate degradation" EXACT [] is_a: GO:0033865 ! nucleoside bisphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0033870 name: thiol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16] synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16] synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16] xref: EC:2.8.2.16 xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN xref: RHEA:14637 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033871 name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "3-OST-2" RELATED [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED [] synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] xref: EC:2.8.2.29 xref: MetaCyc:2.8.2.29-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0033872 name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] synonym: "3-OST-3" RELATED [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30] synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED [] synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] xref: EC:2.8.2.30 xref: MetaCyc:2.8.2.30-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0033873 name: petromyzonol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.31, RHEA:16997] synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31] synonym: "PZ-SULT" RELATED [EC:2.8.2.31] xref: EC:2.8.2.31 xref: KEGG_REACTION:R07797 xref: MetaCyc:2.8.2.31-RXN xref: RHEA:16997 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033874 name: scymnol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.32, RHEA:15477] xref: EC:2.8.2.32 xref: KEGG_REACTION:R07798 xref: MetaCyc:2.8.2.32-RXN xref: RHEA:15477 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033875 name: ribonucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "ribonucleoside bisphosphate metabolism" EXACT [] is_a: GO:0033865 ! nucleoside bisphosphate metabolic process [Term] id: GO:0033876 name: glycochenodeoxycholate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+)." [EC:2.8.2.34, RHEA:17689] synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34] synonym: "BAST" RELATED [EC:2.8.2.34] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34] synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34] xref: EC:2.8.2.34 xref: KEGG_REACTION:R07289 xref: MetaCyc:2.8.2.34-RXN xref: RHEA:17689 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0033877 name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity namespace: molecular_function alt_id: GO:0018728 def: "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate." [EC:2.8.3.15, RHEA:16469] synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT [] xref: EC:2.8.3.15 xref: KEGG_REACTION:R05588 xref: MetaCyc:RXN-864 xref: RHEA:16469 xref: UM-BBD_reactionID:r0329 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0033878 name: hormone-sensitive lipase activity namespace: molecular_function def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79] synonym: "HSL" RELATED [EC:3.1.1.79] xref: EC:3.1.1.79 xref: MetaCyc:STEROL-ESTERASE-RXN xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0033879 name: acetylajmaline esterase activity namespace: molecular_function def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80] synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80] synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80] synonym: "AAE" RELATED [EC:3.1.1.80] synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80] xref: EC:3.1.1.80 xref: MetaCyc:RXN-8652 xref: MetaCyc:RXN-8653 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0033880 name: phenylacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate." [EC:3.1.2.25, RHEA:15337] synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25] xref: EC:3.1.2.25 xref: KEGG_REACTION:R07294 xref: MetaCyc:3.1.2.25-RXN xref: RHEA:15337 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033881 name: bile-acid-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycholoyl-CoA + H(2)O = CoA + deoxycholate + H(+)." [EC:3.1.2.26, RHEA:17693] synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26] synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26] xref: EC:3.1.2.26 xref: KEGG_REACTION:R07295 xref: MetaCyc:BACOAHYDRO-RXN xref: RHEA:17693 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033882 name: choloyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27] synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27] synonym: "PTE-2" RELATED [EC:3.1.2.27] xref: EC:3.1.2.27 xref: MetaCyc:3.1.2.27-RXN xref: RHEA:14541 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0033883 name: pyridoxal phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74] synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74] synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] xref: EC:3.1.3.74 xref: MetaCyc:3.1.3.74-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0033884 name: obsolete phosphoethanolamine/phosphocholine phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "3X11A" RELATED [EC:3.1.3.75] synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] synonym: "phosphoethanolamine phosphohydrolase activity" NARROW [EC:3.1.3.75] synonym: "phosphoethanolamine/phosphocholine phosphatase activity" EXACT [] is_obsolete: true consider: GO:0052731 consider: GO:0052732 [Term] id: GO:0033885 name: 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76, RHEA:16537] synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity" EXACT [EC:3.1.3.76] synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.76] synonym: "dihydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76] synonym: "hydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76] synonym: "hydroxy lipid phosphatase activity" BROAD [EC:3.1.3.76] synonym: "lipid-phosphate phosphatase activity" BROAD [EC:3.1.3.76] synonym: "sEH" RELATED [EC:3.1.3.76] synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76] xref: EC:3.1.3.76 xref: KEGG_REACTION:R07582 xref: MetaCyc:3.1.3.76-RXN xref: RHEA:16537 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0033886 name: cellulose-polysulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7] synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7] xref: EC:3.1.6.7 xref: MetaCyc:3.1.6.7-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033887 name: chondro-4-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.9, RHEA:11444] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9] xref: EC:3.1.6.9 xref: KEGG_REACTION:R03517 xref: MetaCyc:CHONDRO-4-SULFATASE-RXN xref: RHEA:11444 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033888 name: chondro-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.10, RHEA:10536] synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10] xref: EC:3.1.6.10 xref: KEGG_REACTION:R03518 xref: MetaCyc:CHONDRO-6-SULFATASE-RXN xref: RHEA:10536 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033889 name: N-sulfoglucosamine-3-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15] synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15] synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15] xref: EC:3.1.6.15 xref: MetaCyc:3.1.6.15-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0033890 name: ribonuclease D activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5] synonym: "RNase D activity" EXACT [EC:3.1.13.5] xref: EC:3.1.13.5 xref: MetaCyc:3.1.13.5-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033891 name: CC-preferring endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6] synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6] xref: EC:3.1.21.6 xref: MetaCyc:3.1.21.6-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033892 name: deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1] synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1] synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1] xref: EC:3.1.25.1 xref: MetaCyc:3.1.25.1-RXN is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: GO:0033893 name: ribonuclease IV activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6] synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6] xref: EC:3.1.26.6 xref: MetaCyc:3.1.26.6-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033894 name: ribonuclease P4 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7] xref: EC:3.1.26.7 xref: MetaCyc:3.1.26.7-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033895 name: ribonuclease [poly-(U)-specific] activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9] synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9] synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9] xref: EC:3.1.26.9 is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033896 name: ribonuclease IX activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10] synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10] xref: EC:3.1.26.10 xref: MetaCyc:3.1.26.10-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0033897 name: ribonuclease T2 activity namespace: molecular_function def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.19] synonym: "acid ribonuclease activity" EXACT [] synonym: "acid RNase activity" EXACT [] synonym: "base-non-specific ribonuclease activity" EXACT [] synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [] synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:4.6.1.19] synonym: "non-base specific ribonuclease activity" EXACT [] synonym: "nonbase-specific RNase activity" EXACT [] synonym: "nonspecific RNase activity" EXACT [] synonym: "ribonnuclease (non-base specific) activity" EXACT [] synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease II activity" BROAD [EC:4.6.1.19] synonym: "ribonuclease M activity" EXACT [] synonym: "ribonuclease N2 activity" EXACT [] synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1] synonym: "ribonuclease U4 activity" EXACT [] synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [] synonym: "RNAase CL activity" EXACT [] synonym: "RNase (non-base specific) activity" EXACT [] synonym: "RNase II activity" BROAD [EC:4.6.1.19] synonym: "RNase M activity" EXACT [EC:3.1.27.1] synonym: "RNase Ms activity" EXACT [] synonym: "RNase T2 activity" EXACT [EC:4.6.1.19] xref: EC:4.6.1.19 xref: MetaCyc:3.1.27.1-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033898 name: Bacillus subtilis ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:4.6.1.22] synonym: "proteus mirabilis RNase activity" EXACT [] synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [] xref: EC:4.6.1.22 xref: MetaCyc:3.1.27.2-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033899 name: ribonuclease U2 activity namespace: molecular_function def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.20] synonym: "pleospora RNase activity" EXACT [] synonym: "purine specific endoribonuclease activity" EXACT [] synonym: "purine-specific ribonuclease activity" EXACT [] synonym: "purine-specific RNase activity" EXACT [] synonym: "ribonuclease (purine) activity" EXACT [] synonym: "ribonuclease U2 activity" EXACT [EC:4.6.1.20] synonym: "RNase U2 activity" EXACT [EC:4.6.1.20] synonym: "trichoderma koningi RNase III activity" EXACT [] xref: EC:4.6.1.20 xref: MetaCyc:3.1.27.4-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033900 name: ribonuclease F activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7] synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7] synonym: "RNase F activity" EXACT [EC:3.1.27.7] xref: EC:3.1.27.7 xref: MetaCyc:3.1.27.7-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033901 name: ribonuclease V activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8] synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8] xref: EC:3.1.27.8 xref: MetaCyc:3.1.27.8-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033902 name: rRNA endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10] synonym: "alpha-sarcin" RELATED [EC:3.1.27.10] xref: EC:3.1.27.10 xref: MetaCyc:3.1.27.10-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0033903 name: obsolete endo-1,3(4)-beta-glucanase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] comment: This term was made obsolete because it was representing two different activities, for which new GO terms have now been created: GO:0052861 glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group and GO:0052862 glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group. synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3(4)-beta-glucanase activity" EXACT [] synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1,3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6] synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6] synonym: "laminaranase activity" BROAD [EC:3.2.1.6] synonym: "laminarinase activity" BROAD [EC:3.2.1.6] xref: EC:3.2.1.6 xref: MetaCyc:3.2.1.6-RXN is_obsolete: true consider: GO:0052861 consider: GO:0052862 [Term] id: GO:0033904 name: dextranase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11] synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11] synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11] synonym: "DL 2" RELATED [EC:3.2.1.11] synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11] synonym: "endodextranase activity" EXACT [EC:3.2.1.11] xref: EC:3.2.1.11 xref: MetaCyc:3.2.1.11-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033905 name: xylan endo-1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans." [EC:3.2.1.32] synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32] synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] synonym: "xylanase activity" BROAD [EC:3.2.1.32] xref: EC:3.2.1.32 xref: MetaCyc:3.2.1.32-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0033906 name: hyaluronoglucuronidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36] synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36] synonym: "orgelase activity" EXACT [EC:3.2.1.36] xref: EC:3.2.1.36 xref: MetaCyc:3.2.1.36-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033907 name: beta-D-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38] synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38] synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38] xref: EC:3.2.1.38 xref: MetaCyc:3.2.1.38-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033908 name: beta-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43] synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43] xref: EC:3.2.1.43 xref: MetaCyc:3.2.1.43-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033909 name: fucoidanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44] synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44] xref: EC:3.2.1.44 xref: MetaCyc:3.2.1.44-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033910 name: glucan 1,4-alpha-maltotetraohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60] synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60] synonym: "G4-amylase activity" EXACT [EC:3.2.1.60] synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60] synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60] xref: EC:3.2.1.60 xref: MetaCyc:3.2.1.60-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033911 name: mycodextranase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61] synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61] xref: EC:3.2.1.61 xref: MetaCyc:3.2.1.61-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033912 name: 2,6-beta-fructan 6-levanbiohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64] synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64] xref: EC:3.2.1.64 xref: MetaCyc:3.2.1.64-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033913 name: glucan endo-1,2-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans." [EC:3.2.1.71] synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71] synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71] synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71] xref: EC:3.2.1.71 xref: MetaCyc:3.2.1.71-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033914 name: xylan 1,3-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans." [EC:3.2.1.72] synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72] synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] xref: EC:3.2.1.72 xref: MetaCyc:3.2.1.72-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0033915 name: mannan 1,2-(1,3)-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose." [EC:3.2.1.77] synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77] synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77] xref: EC:3.2.1.77 xref: MetaCyc:3.2.1.77-RXN is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0033916 name: beta-agarase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81] synonym: "AgaA" RELATED [EC:3.2.1.81] synonym: "AgaB" RELATED [EC:3.2.1.81] synonym: "agarase activity" BROAD [EC:3.2.1.81] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81] synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81] xref: EC:3.2.1.81 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033917 name: exo-poly-alpha-galacturonosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82] synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82] synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82] xref: EC:3.2.1.82 xref: MetaCyc:3.2.1.82-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033918 name: kappa-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83] synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83] xref: EC:3.2.1.83 xref: MetaCyc:3.2.1.83-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033919 name: glucan 1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84] synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84] synonym: "glucosidase II activity" RELATED [EC:3.2.1.84, GOC:vw] xref: EC:3.2.1.84 xref: MetaCyc:3.2.1.84-RXN xref: Reactome:R-HSA-532667 "Removal of the second glucose by glucosidase II" xref: Reactome:R-HSA-548890 "Removal of the third glucose by glucosidase II and release from the chaperone" is_a: GO:0090600 ! alpha-1,3-glucosidase activity [Term] id: GO:0033920 name: 6-phospho-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85] xref: EC:3.2.1.85 xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033921 name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87] synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87] xref: EC:3.2.1.87 xref: MetaCyc:3.2.1.87-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033922 name: peptidoglycan beta-N-acetylmuramidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92] synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92] synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92] xref: EC:3.2.1.92 xref: MetaCyc:3.2.1.92-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033923 name: glucan 1,6-alpha-isomaltosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94] synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94] synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94] synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94] xref: EC:3.2.1.94 xref: MetaCyc:3.2.1.94-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033924 name: dextran 1,6-alpha-isomaltotriosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95] synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] xref: EC:3.2.1.95 xref: MetaCyc:3.2.1.95-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033925 name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96] synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96] synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96] synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96] synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96] synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] xref: EC:3.2.1.96 xref: MetaCyc:3.2.1.96-RXN xref: Reactome:R-HSA-8853379 "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033926 name: glycopeptide alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins." [EC:3.2.1.97, MetaCyc:3.2.1.97-RXN] synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97] synonym: "endo-alpha-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] xref: EC:3.2.1.97 xref: MetaCyc:3.2.1.97-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0033927 name: glucan 1,4-alpha-maltohexaosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98] synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98] synonym: "G6-amylase activity" EXACT [EC:3.2.1.98] synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98] xref: EC:3.2.1.98 xref: MetaCyc:3.2.1.98-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033928 name: mannan 1,4-mannobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100] synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100] synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100] synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100] synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100] xref: EC:3.2.1.100 xref: MetaCyc:3.2.1.100-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033929 name: blood-group-substance endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102] synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102] xref: EC:3.2.1.102 xref: MetaCyc:3.2.1.102-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033930 name: keratan-sulfate endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103] synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103] synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103] synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103] synonym: "keratanase activity" EXACT [EC:3.2.1.103] xref: EC:3.2.1.103 xref: MetaCyc:3.2.1.103-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033931 name: endogalactosaminidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109] synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109] xref: EC:3.2.1.109 xref: MetaCyc:3.2.1.109-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0033932 name: 1,3-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111] synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111] synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111] xref: EC:3.2.1.111 xref: MetaCyc:3.2.1.111-RXN is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0033933 name: branched-dextran exo-1,2-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115] synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115] synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115] synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115] xref: EC:3.2.1.115 xref: MetaCyc:3.2.1.115-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0033934 name: glucan 1,4-alpha-maltotriohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116] synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116] synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116] xref: EC:3.2.1.116 xref: MetaCyc:3.2.1.116-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033935 name: oligoxyloglucan beta-glycosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120] synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120] xref: EC:3.2.1.120 xref: MetaCyc:3.2.1.120-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033936 name: polymannuronate hydrolase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121] synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121] synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121] xref: EC:3.2.1.121 xref: MetaCyc:3.2.1.121-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033937 name: 3-deoxy-2-octulosonidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124] synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124] synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124] synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124] xref: EC:3.2.1.124 xref: MetaCyc:3.2.1.124-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033938 name: 1,6-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127] synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127] xref: EC:3.2.1.127 xref: MetaCyc:3.2.1.127-RXN is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0033939 name: xylan alpha-1,2-glucuronosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131] synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131] synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131] xref: EC:3.2.1.131 xref: MetaCyc:3.2.1.131-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033940 name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136] synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136] synonym: "feraxanase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136] synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136] xref: EC:3.2.1.136 xref: MetaCyc:3.2.1.136-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0033941 name: mannan exo-1,2-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose." [EC:3.2.1.137] synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137] synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137] xref: EC:3.2.1.137 xref: MetaCyc:3.2.1.137-RXN is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0033942 name: 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141] synonym: "4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141] synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141] synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] xref: EC:3.2.1.141 xref: MetaCyc:3.2.1.141-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033943 name: galactan 1,3-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145] synonym: "galactan (1,3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145] synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145] xref: EC:3.2.1.145 xref: MetaCyc:3.2.1.145-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0033944 name: beta-galactofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146] synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146] xref: EC:3.2.1.146 xref: MetaCyc:3.2.1.146-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033945 name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150] synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150] synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150] xref: EC:3.2.1.150 xref: MetaCyc:3.2.1.150-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033946 name: xyloglucan-specific endo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.151] synonym: "1,4-beta-D-glucan glucanohydrolase activity" BROAD [EC:3.2.1.151] synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] synonym: "XEG" RELATED [EC:3.2.1.151] synonym: "XH" RELATED [EC:3.2.1.151] synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151] synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151] xref: EC:3.2.1.151 xref: MetaCyc:3.2.1.151-RXN is_a: GO:0052736 ! beta-glucanase activity [Term] id: GO:0033947 name: mannosylglycoprotein endo-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152] synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152] xref: EC:3.2.1.152 xref: MetaCyc:3.2.1.152-RXN is_a: GO:0004567 ! beta-mannosidase activity [Term] id: GO:0033948 name: fructan beta-(2,1)-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153] synonym: "1-FEH II" RELATED [EC:3.2.1.153] synonym: "1-FEH w1" RELATED [EC:3.2.1.153] synonym: "1-FEH w2" RELATED [EC:3.2.1.153] synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2,1)-fructan exohydrolase activity" EXACT [EC:3.2.1.153] synonym: "beta-(2,1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153] xref: EC:3.2.1.153 xref: MetaCyc:3.2.1.153-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033949 name: fructan beta-(2,6)-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154] synonym: "6-FEH" RELATED [EC:3.2.1.154] synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154] synonym: "beta-(2,6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154] xref: EC:3.2.1.154 xref: MetaCyc:3.2.1.154-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033950 name: xyloglucan-specific exo-beta-1,4-glucanase activity namespace: molecular_function def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.155] synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155] synonym: "Cel74A" RELATED [EC:3.2.1.155] xref: EC:3.2.1.155 xref: MetaCyc:3.2.1.155-RXN is_a: GO:0052736 ! beta-glucanase activity [Term] id: GO:0033951 name: oligosaccharide reducing-end xylanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156] synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156] synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156] synonym: "Rex" RELATED [EC:3.2.1.156] xref: EC:3.2.1.156 xref: MetaCyc:3.2.1.156-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033952 name: iota-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157] synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157] xref: EC:3.2.1.157 xref: MetaCyc:3.2.1.157-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033953 name: alpha-agarase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158] synonym: "agarase A33 activity" NARROW [EC:3.2.1.158] synonym: "agarase activity" BROAD [EC:3.2.1.158] synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158] xref: EC:3.2.1.158 xref: MetaCyc:3.2.1.158-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033954 name: alpha-neoagaro-oligosaccharide hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159] synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159] synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159] xref: EC:3.2.1.159 xref: MetaCyc:3.2.1.159-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033955 name: mitochondrial DNA inheritance namespace: biological_process alt_id: GO:0090142 def: "The process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah] synonym: "mitochondrial chromosome segregation" RELATED [] synonym: "mitochondrial DNA segregation" RELATED [] is_a: GO:0000002 ! mitochondrial genome maintenance relationship: part_of GO:0000266 ! mitochondrial fission [Term] id: GO:0033956 name: beta-apiosyl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161] synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161] synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161] synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161] xref: EC:3.2.1.161 xref: MetaCyc:3.2.1.161-RXN xref: MetaCyc:RXN-9156 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0033957 name: lambda-carrageenase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162] synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162] xref: EC:3.2.1.162 xref: MetaCyc:3.2.1.162-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0033958 name: DNA-deoxyinosine glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15] synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15] synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15] synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15] synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15] xref: EC:3.2.2.15 xref: MetaCyc:3.2.2.15-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0033959 name: deoxyribodipyrimidine endonucleosidase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17] synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17] synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17] synonym: "endonuclease V activity" BROAD [EC:3.2.2.17] synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17] synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17] synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17] xref: EC:3.2.2.17 xref: MetaCyc:3.2.2.17-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0033960 name: N-methyl nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose." [EC:3.2.2.25, RHEA:10880] synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25] synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25] synonym: "N-MeNase activity" EXACT [EC:3.2.2.25] synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25] xref: EC:3.2.2.25 xref: KEGG_REACTION:R07918 xref: MetaCyc:RXN-7597 xref: RHEA:10880 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0033961 name: cis-stilbene-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "mEH" RELATED [EC:3.3.2.9] synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] xref: EC:3.3.2.9 xref: MetaCyc:3.3.2.9-RXN xref: Reactome:R-HSA-5694077 "EPHX1 hydrates BaP4,5O to BaP4,5-DHD" xref: RHEA:23900 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0033962 name: cytoplasmic mRNA processing body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] synonym: "P body assembly" EXACT [] synonym: "P body biogenesis" RELATED [] synonym: "P-body assembly" EXACT [] is_a: GO:0070925 ! organelle assembly [Term] id: GO:0033963 name: cholesterol-5,6-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11] synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11] synonym: "ChEH" RELATED [EC:3.3.2.11] synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11] xref: EC:3.3.2.11 xref: MetaCyc:RXN-8650 xref: MetaCyc:RXN-8651 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0033964 name: glycosphingolipid deacylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69] synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69] synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69] xref: EC:3.5.1.69 xref: MetaCyc:3.5.1.69-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033965 name: aculeacin-A deacylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70] synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70] synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70] xref: EC:3.5.1.70 xref: MetaCyc:3.5.1.70-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033966 name: N-substituted formamide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91] synonym: "NfdA" RELATED [EC:3.5.1.91] xref: MetaCyc:3.5.1.91-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033967 name: box C/D snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:mah] is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0033968 name: glutaryl-7-aminocephalosporanic-acid acylase activity namespace: molecular_function def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93] synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93] synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] synonym: "CA" RELATED [EC:3.5.1.93] synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93] synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93] synonym: "GA" RELATED [EC:3.5.1.93] synonym: "GCA" RELATED [EC:3.5.1.93] synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93] synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] xref: EC:3.5.1.93 xref: MetaCyc:3.5.1.93-RXN xref: RHEA:23508 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033969 name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94, RHEA:19737] synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94] synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94] synonym: "PuuD" RELATED [EC:3.5.1.94] synonym: "YcjL" RELATED [EC:3.5.1.94] xref: EC:3.5.1.94 xref: KEGG_REACTION:R07419 xref: MetaCyc:RXN0-3942 xref: RHEA:19737 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033970 name: N-malonylurea hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea." [EC:3.5.1.95, RHEA:17361] synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95] synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95] xref: EC:3.5.1.95 xref: KEGG_REACTION:R07629 xref: MetaCyc:3.5.1.95-RXN xref: RHEA:17361 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0033971 name: hydroxyisourate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)." [EC:3.5.2.17, RHEA:23736] synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17] synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17] synonym: "HIUHase activity" EXACT [EC:3.5.2.17] xref: EC:3.5.2.17 xref: KEGG_REACTION:R06601 xref: MetaCyc:3.5.2.17-RXN xref: RHEA:23736 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0033972 name: proclavaminate amidinohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea." [EC:3.5.3.22, RHEA:17001] synonym: "PAH" RELATED [EC:3.5.3.22] synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22] synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22] xref: EC:3.5.3.22 xref: KEGG_REACTION:R05357 xref: MetaCyc:3.5.3.22-RXN xref: RHEA:17001 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0033973 name: dCTP deaminase (dUMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+)." [EC:3.5.4.30, RHEA:19205] synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30] xref: EC:3.5.4.30 xref: KEGG_REACTION:R07307 xref: MetaCyc:3.5.4.30-RXN xref: RHEA:19205 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0033974 name: nucleoside phosphoacylhydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mixed phospho-anhydride bonds." [EC:3.6.1.24] synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24] xref: EC:3.6.1.24 xref: MetaCyc:3.6.1.24-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0033975 name: (R)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9] synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9] synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9] synonym: "D-DEX" RELATED [EC:3.8.1.9] xref: EC:3.8.1.9 xref: MetaCyc:3.8.1.9-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033976 name: 2-haloacid dehalogenase (configuration-inverting) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10] synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10] synonym: "DL-DEXi" RELATED [EC:3.8.1.10] xref: EC:3.8.1.10 xref: MetaCyc:3.8.1.10-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033977 name: 2-haloacid dehalogenase (configuration-retaining) activity namespace: molecular_function def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11] synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11] synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "DL-DEXr" RELATED [EC:3.8.1.11] xref: EC:3.8.1.11 xref: MetaCyc:3.8.1.11-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0033978 name: phosphonopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate." [EC:3.11.1.3, RHEA:16673] synonym: "PPH" RELATED [EC:3.11.1.3] xref: EC:3.11.1.3 xref: KEGG_REACTION:R08200 xref: MetaCyc:3.11.1.3-RXN xref: RHEA:16673 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0033979 name: box H/ACA snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah] is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0033980 name: phosphonopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768] synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82] synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82] xref: EC:4.1.1.82 xref: KEGG_REACTION:R04053 xref: MetaCyc:4.1.1.82-RXN xref: RHEA:20768 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033981 name: D-dopachrome decarboxylase activity namespace: molecular_function alt_id: GO:0030928 def: "Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2)." [EC:4.1.1.84, RHEA:18441] synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84] synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84] synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome decarboxylase activity" EXACT [] synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84] xref: EC:4.1.1.84 xref: KEGG_REACTION:R07313 xref: MetaCyc:4.1.1.84-RXN xref: RHEA:18441 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033982 name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2)." [EC:4.1.1.85, RHEA:14353] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85] synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85] synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85] synonym: "KGPDC" RELATED [EC:4.1.1.85] synonym: "SgaH" RELATED [EC:4.1.1.85] synonym: "SgbH" RELATED [EC:4.1.1.85] synonym: "UlaD" RELATED [EC:4.1.1.85] xref: EC:4.1.1.85 xref: KEGG_REACTION:R07125 xref: MetaCyc:RXN0-705 xref: RHEA:14353 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033983 name: diaminobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2)." [EC:4.1.1.86, RHEA:15689] synonym: "DABA DC" RELATED [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86] synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86] xref: EC:4.1.1.86 xref: KEGG_REACTION:R07650 xref: MetaCyc:4.1.1.86-RXN xref: RHEA:15689 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0033984 name: indole-3-glycerol-phosphate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8] synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "BX1" RELATED [EC:4.1.2.8] synonym: "IGL" RELATED [EC:4.1.2.8] synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8] synonym: "indole synthase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8] synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8] synonym: "tryptophan synthase alpha activity" NARROW [EC:4.1.2.8] synonym: "tryptophan synthase alpha subunit activity" NARROW [EC:4.1.2.8] synonym: "TSA" RELATED [EC:4.1.2.8] xref: EC:4.1.2.8 xref: KEGG_REACTION:R02340 xref: MetaCyc:4.1.2.8-RXN xref: MetaCyc:RXN0-2381 xref: RHEA:14081 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0033985 name: acidocalcisome lumen namespace: cellular_component def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0020022 ! acidocalcisome [Term] id: GO:0033986 name: response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl] is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol [Term] id: GO:0033987 name: 2-hydroxyisoflavanone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105] synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105] xref: EC:4.2.1.105 xref: MetaCyc:RXN-3284 xref: RHEA:16445 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033988 name: bile-acid 7alpha-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O." [EC:4.2.1.106, RHEA:10436] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106] synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106] synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106] xref: EC:4.2.1.106 xref: KEGG_REACTION:R07318 xref: MetaCyc:4.2.1.106-RXN xref: RHEA:10436 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033989 name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107] synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107] synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107] synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107] xref: EC:4.2.1.107 xref: MetaCyc:4.2.1.107-RXN xref: Reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" xref: Reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033990 name: ectoine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O." [EC:4.2.1.108, RHEA:17281] synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] synonym: "EctC" RELATED [EC:4.2.1.108] synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108] synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] xref: EC:4.2.1.108 xref: KEGG_REACTION:R06979 xref: MetaCyc:R103-RXN xref: RHEA:17281 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033991 name: aldos-2-ulose dehydratase activity namespace: molecular_function def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110] synonym: "AUDH" RELATED [EC:4.2.1.110] synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110] xref: EC:4.2.1.110 xref: MetaCyc:4.2.1.110-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033992 name: 1,5-anhydro-D-fructose dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111] synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111] synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111] synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111] synonym: "AFDH" RELATED [EC:4.2.1.111] xref: EC:4.2.1.111 xref: MetaCyc:4.2.1.111-RXN xref: RHEA:15725 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0033994 name: glucuronan lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14] synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14] xref: EC:4.2.2.14 xref: MetaCyc:4.2.2.14-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033995 name: anhydrosialidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15] synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15] synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] synonym: "sialidase L activity" EXACT [EC:4.2.2.15] xref: EC:4.2.2.15 xref: MetaCyc:4.2.2.15-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033996 name: levan fructotransferase (DFA-IV-forming) activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16] synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16] synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16] synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16] xref: EC:4.2.2.16 xref: MetaCyc:4.2.2.16-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033997 name: inulin fructotransferase (DFA-I-forming) activity namespace: molecular_function def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17] synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17] xref: EC:4.2.2.17 xref: MetaCyc:4.2.2.17-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033998 name: inulin fructotransferase (DFA-III-forming) activity namespace: molecular_function def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18] synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulase II activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18] synonym: "inulinase II activity" EXACT [EC:4.2.2.18] xref: EC:4.2.2.18 xref: MetaCyc:4.2.2.18-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0033999 name: chondroitin B lyase activity namespace: molecular_function def: "Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate." [EC:4.2.2.19] synonym: "ChnB" RELATED [EC:4.2.2.19] synonym: "chonB" RELATED [EC:4.2.2.19] synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19] synonym: "dermatan sulfate lyase activity" EXACT [] xref: EC:4.2.2.19 xref: MetaCyc:4.2.2.19-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0034000 name: chondroitin-sulfate-ABC endolyase activity namespace: molecular_function def: "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20] synonym: "chondroitinase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20] synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20] xref: EC:4.2.2.20 xref: MetaCyc:4.2.2.20-RXN is_a: GO:0047486 ! chondroitin ABC lyase activity [Term] id: GO:0034001 name: chondroitin-sulfate-ABC exolyase activity namespace: molecular_function def: "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21] synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21] synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21] synonym: "chondroitinase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21] synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21] xref: EC:4.2.2.21 xref: MetaCyc:4.2.2.21-RXN is_a: GO:0047486 ! chondroitin ABC lyase activity [Term] id: GO:0034002 name: (R)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate." [EC:4.2.3.20, RHEA:10940] synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20] synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20] xref: EC:4.2.3.20 xref: KEGG_REACTION:R06120 xref: MetaCyc:4.2.3.20-RXN xref: RHEA:10940 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034003 name: vetispiradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene." [EC:4.2.3.21, RHEA:10340] synonym: "HVS" RELATED [EC:4.2.3.21] synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21] synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21] xref: EC:4.2.3.21 xref: KEGG_REACTION:R06523 xref: MetaCyc:RXN-4823 xref: RHEA:10340 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034004 name: germacradienol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate." [EC:4.2.3.22] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22] xref: EC:4.2.3.22 xref: KEGG_REACTION:R07647 xref: MetaCyc:RXN-8648 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034005 name: germacrene-A synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23, RHEA:12516] synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23] synonym: "GAS" RELATED [EC:4.2.3.23] synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23] xref: EC:4.2.3.23 xref: KEGG_REACTION:R07649 xref: MetaCyc:4.2.3.23-RXN xref: RHEA:12516 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034006 name: amorpha-4,11-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24, RHEA:18325] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24] synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24] xref: EC:4.2.3.24 xref: KEGG_REACTION:R07630 xref: MetaCyc:4.2.3.24-RXN xref: MetaCyc:RXN-8046 xref: RHEA:18325 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0034007 name: S-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate." [EC:4.2.3.25, RHEA:24116] synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25] synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25] synonym: "LIS" RELATED [EC:4.2.3.25] xref: EC:4.2.3.25 xref: KEGG_REACTION:R07631 xref: MetaCyc:4.2.3.25-RXN xref: RHEA:24116 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034008 name: R-linalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate." [EC:4.2.3.26, RHEA:15809] synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26] synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26] xref: EC:4.2.3.26 xref: KEGG_REACTION:R07632 xref: MetaCyc:4.2.3.26-RXN xref: RHEA:15809 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034009 name: isoprene synthase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene." [EC:4.2.3.27, RHEA:13369] synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27] synonym: "ISPC" RELATED [EC:4.2.3.27] synonym: "ISPS" RELATED [EC:4.2.3.27] xref: EC:4.2.3.27 xref: KEGG_REACTION:R08199 xref: MetaCyc:4.2.3.27-RXN xref: RHEA:13369 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034010 name: sulfolactate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite." [EC:4.4.1.24, RHEA:21428] synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24] synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24] synonym: "Suy" RELATED [EC:4.4.1.24] synonym: "SuyAB" RELATED [EC:4.4.1.24] xref: EC:4.4.1.24 xref: KEGG_REACTION:R07633 xref: MetaCyc:4.4.1.24-RXN xref: RHEA:21428 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034011 name: L-cysteate sulfo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite." [EC:4.4.1.25, RHEA:13441] synonym: "CuyA" RELATED [EC:4.4.1.25] synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25] synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25] xref: EC:4.4.1.25 xref: KEGG_REACTION:R07634 xref: MetaCyc:4.4.1.25-RXN xref: RHEA:13441 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034012 name: FAD-AMP lyase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15] synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15] synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15] synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15] xref: EC:4.6.1.15 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0034013 name: aliphatic aldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5] synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5] synonym: "OxdA" RELATED [EC:4.99.1.5] xref: EC:4.99.1.5 xref: MetaCyc:4.99.1.5-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0034014 name: response to triglyceride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl] synonym: "response to triacylglyceride" EXACT [] synonym: "response to triacylglycerol" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0034015 name: L-ribulose-5-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22] synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22] synonym: "SgaU" RELATED [EC:5.1.3.22] synonym: "UlaE" RELATED [EC:5.1.3.22] xref: EC:5.1.3.22 xref: MetaCyc:LXULRU5P-RXN xref: RHEA:18497 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0034016 name: polyenoic fatty acid isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate." [EC:5.3.3.13, RHEA:14889] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13] synonym: "PFI" RELATED [EC:5.3.3.13] xref: EC:5.3.3.13 xref: KEGG_REACTION:R06502 xref: MetaCyc:5.3.3.13-RXN xref: RHEA:14889 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034017 name: trans-2-decenoyl-acyl-carrier-protein isomerase activity namespace: molecular_function alt_id: GO:0043832 def: "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]." [EC:5.3.3.14, IMG:02508] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14] synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14] synonym: "FabM" RELATED [EC:5.3.3.14] synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT [] synonym: "trans-2, cis-3 decenoyl-ACP isomerase activity" EXACT [] synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] xref: EC:5.3.3.14 xref: MetaCyc:5.3.3.14-RXN is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034018 name: ascopyrone tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.2.7] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.2.7] synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.2.7] synonym: "APM tautomerase activity" EXACT [EC:5.3.2.7] synonym: "APTM" RELATED [EC:5.3.2.7] synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.2.7] synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.2.7] synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.2.7] xref: EC:5.3.2.7 xref: MetaCyc:5.3.3.15-RXN xref: RHEA:22568 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0034019 name: obsolete capsanthin/capsorubin synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin." [EC:5.3.99.8] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8] synonym: "capsanthin/capsorubin synthase activity" EXACT [] synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" NARROW [EC:5.3.99.8] is_obsolete: true consider: GO:0052727 consider: GO:0052728 [Term] id: GO:0034020 name: neoxanthin synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin." [EC:5.3.99.9, RHEA:10128] synonym: "NSY" RELATED [EC:5.3.99.9] synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9] xref: EC:5.3.99.9 xref: KEGG_REACTION:R06948 xref: MetaCyc:RXN1F-155 xref: RHEA:10128 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034021 name: response to silicon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl] synonym: "response to silica" EXACT [] synonym: "response to silox" EXACT [] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0034022 name: 3-(hydroxyamino)phenol mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3, RHEA:20577] synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3] synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3] synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3] xref: EC:5.4.4.3 xref: KEGG_REACTION:R06988 xref: MetaCyc:5.4.4.3-RXN xref: RHEA:20577 xref: UM-BBD_enzymeID:e0953 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0034023 name: 5-(carboxyamino)imidazole ribonucleotide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18] synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18] synonym: "class I PurE" RELATED [EC:5.4.99.18] synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18] synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18] synonym: "PurE" RELATED [EC:5.4.99.18] xref: EC:5.4.99.18 xref: MetaCyc:5.4.99.18-RXN xref: RHEA:13193 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034024 name: glutamate-putrescine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate." [EC:6.3.1.11, RHEA:13633] synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11] synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11] synonym: "YcjK" RELATED [EC:6.3.1.11] xref: EC:6.3.1.11 xref: KEGG_REACTION:R07414 xref: MetaCyc:RXN0-3901 xref: RHEA:13633 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0034025 name: D-aspartate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12] synonym: "aslfm" RELATED [EC:6.3.1.12] synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12] synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12] xref: EC:6.3.1.12 xref: MetaCyc:6.3.1.12-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0034026 name: L-amino-acid alpha-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.49] synonym: "bacilysin synthetase activity" EXACT [] synonym: "L-amino acid alpha-ligase activity" EXACT [] synonym: "L-amino acid ligase activity" EXACT [] synonym: "YwfE" RELATED [] xref: EC:6.3.2.49 xref: MetaCyc:6.3.2.28-RXN xref: RHEA:44332 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0034027 name: (carboxyethyl)arginine beta-lactam-synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+)." [EC:6.3.3.4, RHEA:23620] synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4] synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] xref: EC:6.3.3.4 xref: KEGG_REACTION:R05467 xref: MetaCyc:6.3.3.4-RXN xref: RHEA:23620 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0034028 name: 5-(carboxyamino)imidazole ribonucleotide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate." [EC:6.3.4.18, RHEA:19317] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18] synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18] synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18] synonym: "PurK" RELATED [EC:6.3.4.18] xref: EC:6.3.4.18 xref: KEGG_REACTION:R07404 xref: MetaCyc:RXN0-742 xref: RHEA:19317 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0034029 name: 2-oxoglutarate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate." [EC:6.4.1.7, RHEA:20425] synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7] synonym: "CFI" RELATED [EC:6.4.1.7] synonym: "OGC" RELATED [EC:6.4.1.7] synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7] xref: EC:6.4.1.7 xref: KEGG_REACTION:R08201 xref: MetaCyc:RXN-8457 xref: RHEA:20425 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0034030 name: ribonucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "ribonucleoside bisphosphate anabolism" EXACT [] synonym: "ribonucleoside bisphosphate biosynthesis" EXACT [] synonym: "ribonucleoside bisphosphate formation" EXACT [] synonym: "ribonucleoside bisphosphate synthesis" EXACT [] is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process [Term] id: GO:0034031 name: ribonucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "ribonucleoside bisphosphate breakdown" EXACT [] synonym: "ribonucleoside bisphosphate catabolism" EXACT [] synonym: "ribonucleoside bisphosphate degradation" EXACT [] is_a: GO:0033869 ! nucleoside bisphosphate catabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process [Term] id: GO:0034032 name: purine nucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine nucleoside bisphosphate metabolism" EXACT [] is_a: GO:0033865 ! nucleoside bisphosphate metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0034033 name: purine nucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine nucleoside bisphosphate anabolism" EXACT [] synonym: "purine nucleoside bisphosphate biosynthesis" EXACT [] synonym: "purine nucleoside bisphosphate formation" EXACT [] synonym: "purine nucleoside bisphosphate synthesis" EXACT [] is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0034034 name: purine nucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine nucleoside bisphosphate breakdown" EXACT [] synonym: "purine nucleoside bisphosphate catabolism" EXACT [] synonym: "purine nucleoside bisphosphate degradation" EXACT [] is_a: GO:0033869 ! nucleoside bisphosphate catabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0034035 name: purine ribonucleoside bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine ribonucleoside bisphosphate metabolism" EXACT [] is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0034036 name: purine ribonucleoside bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine ribonucleoside bisphosphate anabolism" EXACT [] synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside bisphosphate formation" EXACT [] synonym: "purine ribonucleoside bisphosphate synthesis" EXACT [] is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process [Term] id: GO:0034037 name: purine ribonucleoside bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] synonym: "purine ribonucleoside bisphosphate breakdown" EXACT [] synonym: "purine ribonucleoside bisphosphate catabolism" EXACT [] synonym: "purine ribonucleoside bisphosphate degradation" EXACT [] is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process [Term] id: GO:0034038 name: deoxyhypusine synthase activity namespace: molecular_function def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pde, MetaCyc:2.5.1.46-RXN] comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'. synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46] synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] xref: EC:2.5.1.46 xref: MetaCyc:2.5.1.46-RXN xref: Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A" xref: Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0034039 name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "8-oxoG DNA N-glycosylase activity" EXACT [] is_a: GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity [Term] id: GO:0034040 name: ATPase-coupled lipid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl] synonym: "ATP-dependent lipid transmembrane transporter activity" EXACT [] synonym: "lipid-transporting ATPase activity" BROAD [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0034041 name: ATPase-coupled sterol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl] synonym: "ATP-coupled sterol transmembrane transporter activity" EXACT [] synonym: "ATP-dependent sterol transmembrane transporter activity" RELATED [] synonym: "sterol-transporting ATPase activity" RELATED [] is_a: GO:0015248 ! sterol transporter activity is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0034042 name: 5-formyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-foU DNA N-glycosylase activity" EXACT [] is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [Term] id: GO:0034043 name: 5-hydroxymethyluracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] synonym: "5-hmU DNA N-glycosylase activity" EXACT [] is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [Term] id: GO:0034044 name: exomer complex namespace: cellular_component def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0034045 name: phagophore assembly site membrane namespace: cellular_component def: "A cellular membrane associated with the phagophore assembly site." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] synonym: "isolation membrane" RELATED [] synonym: "PAS membrane" EXACT [] synonym: "phagophore" RELATED [PMID:20811355] synonym: "pre-autophagosomal structure membrane" NARROW [] is_a: GO:0098805 ! whole membrane relationship: part_of GO:0000407 ! phagophore assembly site [Term] id: GO:0034046 name: poly(G) binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule." [GOC:mah] synonym: "poly(G) binding, within an RNA molecule" EXACT [] synonym: "poly(rG) binding" EXACT [GOC:mah] is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0034050 name: host programmed cell death induced by symbiont namespace: biological_process def: "Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules." [GOC:pamgo_curators] comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'induction by symbiont of host programmed cell death ; GO:0052044'. is_a: GO:0012501 ! programmed cell death [Term] id: GO:0034051 name: negative regulation of plant-type hypersensitive response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators] synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators] synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] is_a: GO:0010363 ! regulation of plant-type hypersensitive response is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009626 ! plant-type hypersensitive response relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0034052 name: positive regulation of plant-type hypersensitive response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators] synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators] synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] is_a: GO:0010363 ! regulation of plant-type hypersensitive response is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009626 ! plant-type hypersensitive response relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0034053 name: modulation by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'. synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0052040 ! modulation by symbiont of host programmed cell death [Term] id: GO:0034054 name: suppression by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'. synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators] synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators] synonym: "inhibition of HR" NARROW [GOC:pamgo_curators] synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "negative regulation by symbiont of host defense-related programmed cell death" EXACT [] synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "suppression by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "suppression of HR" NARROW [GOC:pamgo_curators] is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death [Term] id: GO:0034055 name: positive regulation by symbiont of host defense-related programmed cell death namespace: biological_process def: "Any process in which a symbiont activates or increases the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of plant-type hypersensitive response ; GO:0034052'. synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "activation of HR" NARROW [GOC:pamgo_curators] synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "enhancement by symbiont of host defense-related PCDprogrammed cell death" NARROW [GOC:pamgo_curators] synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] synonym: "positive regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] synonym: "positive regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death [Term] id: GO:0034056 name: estrogen response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "ERE binding" EXACT [] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding [Term] id: GO:0034057 name: RNA strand-exchange activity namespace: molecular_function def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100] is_a: GO:0003725 ! double-stranded RNA binding is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0034058 name: endosomal vesicle fusion namespace: biological_process def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] synonym: "endosome vesicle fusion" EXACT [] is_a: GO:0006906 ! vesicle fusion [Term] id: GO:0034059 name: response to anoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. synonym: "response to anoxic stress" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0034060 name: cyanelle stroma namespace: cellular_component def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0034061 name: DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:mah] synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7] is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0071897 ! DNA biosynthetic process [Term] id: GO:0034062 name: 5'-3' RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end." [EC:2.7.7.6, GOC:mah, GOC:pf] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase activity" BROAD [] synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: Reactome:R-HSA-5696807 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" xref: Reactome:R-HSA-6786881 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" is_a: GO:0097747 ! RNA polymerase activity [Term] id: GO:0034063 name: stress granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] synonym: "SG assembly" EXACT [PMID:19825938] is_a: GO:0070925 ! organelle assembly [Term] id: GO:0034064 name: Tor2-Mei2-Ste11 complex namespace: cellular_component def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034066 name: RIC1-RGP1 guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452] synonym: "Ric1p-Rgp1p complex" RELATED [] xref: IntAct:EBI-9517136 is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0034067 name: protein localization to Golgi apparatus namespace: biological_process alt_id: GO:0000042 alt_id: GO:0072600 def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah] synonym: "establishment of protein localization in Golgi" NARROW [] synonym: "establishment of protein localization to Golgi" NARROW [] synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization in Golgi apparatus" EXACT [] synonym: "protein targeting to Golgi" RELATED [] synonym: "protein-Golgi targeting" RELATED [] is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2011-02-14T02:26:36Z [Term] id: GO:0034068 name: aminoglycoside nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb] synonym: "aminoglycoside adenylyltransferase activity" NARROW [] synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0034069 name: aminoglycoside N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb] synonym: "kanamycin acetyltransferase activity" NARROW [] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0034070 name: aminoglycoside 1-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb] is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0034071 name: aminoglycoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah] synonym: "aminoglycoside kinase activity" EXACT [] xref: EC:2.7.1 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0034072 name: squalene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0034073 name: tetrahymanol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = tetrahymanol." [GOC:cb, PMID:18033581] is_a: GO:0034072 ! squalene cyclase activity [Term] id: GO:0034074 name: marneral synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] xref: MetaCyc:RXN-9664 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034075 name: arabidiol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751] xref: EC:4.2.1.124 xref: MetaCyc:RXN-9684 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034076 name: cucurbitadienol synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581] is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0034077 name: butanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY] synonym: "butanediol metabolism" EXACT [] synonym: "butylene glycol metabolic process" EXACT [] synonym: "butylene glycol metabolism" EXACT [] is_a: GO:0042844 ! glycol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0034078 name: butanediol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] synonym: "butanediol breakdown" EXACT [] synonym: "butanediol catabolism" EXACT [] synonym: "butanediol degradation" EXACT [] synonym: "butanediol utilization" RELATED [] synonym: "butylene glycol catabolic process" EXACT [] synonym: "butylene glycol catabolism" EXACT [] is_a: GO:0034077 ! butanediol metabolic process is_a: GO:0042846 ! glycol catabolic process [Term] id: GO:0034079 name: butanediol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] synonym: "butanediol anabolism" EXACT [] synonym: "butanediol biosynthesis" EXACT [] synonym: "butanediol formation" EXACT [] synonym: "butanediol synthesis" EXACT [] synonym: "butylene glycol biosynthesis" EXACT [] synonym: "butylene glycol biosynthetic process" EXACT [] xref: MetaCyc:P125-PWY is_a: GO:0034077 ! butanediol metabolic process is_a: GO:0042845 ! glycol biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0034080 name: CENP-A containing nucleosome assembly namespace: biological_process alt_id: GO:0034509 def: "The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403] synonym: "CenH3-containing nucleosome assembly at centromere" RELATED [] synonym: "CENP-A containing nucleosome assembly at centromere" EXACT [GOC:vw] synonym: "CENP-A deposition" RELATED [GOC:vw] synonym: "CENP-A loading" RELATED [GOC:vw] synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah] synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw] synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah] synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah] is_a: GO:0006336 ! DNA replication-independent nucleosome assembly is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0043486 ! histone exchange relationship: has_part GO:0061644 ! protein localization to CENP-A containing chromatin relationship: part_of GO:0034508 ! centromere complex assembly relationship: part_of GO:0061641 ! CENP-A containing chromatin organization [Term] id: GO:0034081 name: polyketide synthase complex namespace: cellular_component def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085] synonym: "PKS" RELATED [] synonym: "PKS complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034082 name: type II polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085] synonym: "type II PKS" EXACT [] synonym: "type II PKS complex" EXACT [] synonym: "type II polyketide synthase" EXACT [] is_a: GO:0034081 ! polyketide synthase complex [Term] id: GO:0034083 name: type III polyketide synthase complex namespace: cellular_component def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085] synonym: "type III PKS" EXACT [] synonym: "type III PKS complex" EXACT [] synonym: "type III polyketide synthase" EXACT [] is_a: GO:0034081 ! polyketide synthase complex [Term] id: GO:0034084 name: steryl deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159] synonym: "sterol deacetylase activity" EXACT [] is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0034085 name: establishment of sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007062 ! sister chromatid cohesion [Term] id: GO:0034086 name: maintenance of sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007062 ! sister chromatid cohesion [Term] id: GO:0034087 name: establishment of mitotic sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah] is_a: GO:0034085 ! establishment of sister chromatid cohesion is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0034085 ! establishment of sister chromatid cohesion intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0034088 name: maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] synonym: "mitotic cohesion stability" RELATED [] is_a: GO:0034086 ! maintenance of sister chromatid cohesion is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0034089 name: establishment of meiotic sister chromatid cohesion namespace: biological_process def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah] is_a: GO:0034085 ! establishment of sister chromatid cohesion is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0034090 name: maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah] is_a: GO:0034086 ! maintenance of sister chromatid cohesion is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0034091 name: regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0007063 ! regulation of sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034086 ! maintenance of sister chromatid cohesion relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034092 name: negative regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0045875 ! negative regulation of sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034093 name: positive regulation of maintenance of sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0045876 ! positive regulation of sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion [Term] id: GO:0034094 name: regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion is_a: GO:0040020 ! regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034095 name: negative regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0045835 ! negative regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034096 name: positive regulation of maintenance of meiotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0045836 ! positive regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion [Term] id: GO:0034097 name: response to cytokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] synonym: "response to cytokine stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0034098 name: VCP-NPL4-UFD1 AAA ATPase complex namespace: cellular_component def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)." [PMID:11813000, PMID:16179952] synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW [] synonym: "p97-Ufd1-Npl4 complex" EXACT [PMID:12847084] is_a: GO:0098796 ! membrane protein complex relationship: has_part GO:0036501 ! UFD1-NPL4 complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0034099 name: luminal surveillance complex namespace: cellular_component def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005788 ! endoplasmic reticulum lumen [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0034102 name: erythrocyte clearance namespace: biological_process def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397] comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. synonym: "neocytolysis" NARROW [PMID:14754397] synonym: "RBC clearance" EXACT [CL:0000232] synonym: "red blood cell clearance" EXACT [CL:0000232] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0034103 name: regulation of tissue remodeling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048771 ! tissue remodeling relationship: regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034104 name: negative regulation of tissue remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048771 ! tissue remodeling relationship: negatively_regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034105 name: positive regulation of tissue remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048771 ! tissue remodeling relationship: positively_regulates GO:0048771 ! tissue remodeling [Term] id: GO:0034106 name: regulation of erythrocyte clearance namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "regulation of neocytolysis" NARROW [PMID:14754397] synonym: "regulation of RBC clearance" EXACT [CL:0000232] synonym: "regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034102 ! erythrocyte clearance relationship: regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034107 name: negative regulation of erythrocyte clearance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397] synonym: "negative regulation of RBC clearance" EXACT [CL:0000232] synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034102 ! erythrocyte clearance relationship: negatively_regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034108 name: positive regulation of erythrocyte clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397] synonym: "positive regulation of RBC clearance" EXACT [CL:0000232] synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0034106 ! regulation of erythrocyte clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034102 ! erythrocyte clearance relationship: positively_regulates GO:0034102 ! erythrocyte clearance [Term] id: GO:0034109 name: homotypic cell-cell adhesion namespace: biological_process def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0034110 name: regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034109 ! homotypic cell-cell adhesion relationship: regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034111 name: negative regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034112 name: positive regulation of homotypic cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034109 ! homotypic cell-cell adhesion relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034113 name: heterotypic cell-cell adhesion namespace: biological_process def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add] comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0034114 name: regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034113 ! heterotypic cell-cell adhesion relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034115 name: negative regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034116 name: positive regulation of heterotypic cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion [Term] id: GO:0034117 name: erythrocyte aggregation namespace: biological_process def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543] synonym: "RBC aggregation" EXACT [CL:0000232] synonym: "red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034109 ! homotypic cell-cell adhesion [Term] id: GO:0034118 name: regulation of erythrocyte aggregation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "regulation of RBC aggregation" EXACT [CL:0000232] synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034117 ! erythrocyte aggregation relationship: regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034119 name: negative regulation of erythrocyte aggregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0034118 ! regulation of erythrocyte aggregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034117 ! erythrocyte aggregation relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034120 name: positive regulation of erythrocyte aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232] is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:0034118 ! regulation of erythrocyte aggregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034117 ! erythrocyte aggregation relationship: positively_regulates GO:0034117 ! erythrocyte aggregation [Term] id: GO:0034121 name: regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR signaling pathway" EXACT [] synonym: "regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002224 ! toll-like receptor signaling pathway relationship: regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034122 name: negative regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034123 name: positive regulation of toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor signalling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002224 ! toll-like receptor signaling pathway relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034124 name: regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT [] synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034125 name: negative regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT [] synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034126 name: positive regulation of MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT [] synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway [Term] id: GO:0034127 name: regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT [] synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034128 name: negative regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT [] synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034129 name: positive regulation of MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT [] synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT [] synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway [Term] id: GO:0034130 name: toll-like receptor 1 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR1 signaling pathway" EXACT [] synonym: "toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034131 name: regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR1 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034130 ! toll-like receptor 1 signaling pathway relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034132 name: negative regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR1 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034133 name: positive regulation of toll-like receptor 1 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR1 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway [Term] id: GO:0034134 name: toll-like receptor 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR2 signaling pathway" EXACT [] synonym: "toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034135 name: regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR2 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034134 ! toll-like receptor 2 signaling pathway relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034136 name: negative regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR2 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034137 name: positive regulation of toll-like receptor 2 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR2 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway [Term] id: GO:0034138 name: toll-like receptor 3 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR3 signaling pathway" EXACT [] synonym: "toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034139 name: regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR3 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034138 ! toll-like receptor 3 signaling pathway relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034140 name: negative regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR3 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034141 name: positive regulation of toll-like receptor 3 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR3 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway [Term] id: GO:0034142 name: toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR4 signaling pathway" EXACT [] synonym: "toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034143 name: regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR4 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034142 ! toll-like receptor 4 signaling pathway relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034144 name: negative regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR4 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034145 name: positive regulation of toll-like receptor 4 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR4 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway [Term] id: GO:0034146 name: toll-like receptor 5 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR5 signaling pathway" EXACT [] synonym: "toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034147 name: regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR5 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034146 ! toll-like receptor 5 signaling pathway relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034148 name: negative regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR5 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034149 name: positive regulation of toll-like receptor 5 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR5 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway [Term] id: GO:0034150 name: toll-like receptor 6 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR6 signaling pathway" EXACT [] synonym: "toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034151 name: regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR6 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034150 ! toll-like receptor 6 signaling pathway relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034152 name: negative regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR6 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034153 name: positive regulation of toll-like receptor 6 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR6 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway [Term] id: GO:0034154 name: toll-like receptor 7 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR7 signaling pathway" EXACT [] synonym: "toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034155 name: regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR7 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034154 ! toll-like receptor 7 signaling pathway relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034156 name: negative regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR7 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034157 name: positive regulation of toll-like receptor 7 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR7 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway [Term] id: GO:0034158 name: toll-like receptor 8 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR8 signaling pathway" EXACT [] synonym: "toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034159 name: regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR8 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034158 ! toll-like receptor 8 signaling pathway relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034160 name: negative regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR8 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034161 name: positive regulation of toll-like receptor 8 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR8 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway [Term] id: GO:0034162 name: toll-like receptor 9 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR9 signaling pathway" EXACT [] synonym: "toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034163 name: regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR9 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034162 ! toll-like receptor 9 signaling pathway relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034164 name: negative regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR9 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034165 name: positive regulation of toll-like receptor 9 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR9 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway [Term] id: GO:0034166 name: toll-like receptor 10 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR10 signaling pathway" EXACT [] synonym: "toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034167 name: regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR10 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034166 ! toll-like receptor 10 signaling pathway relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034168 name: negative regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR10 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034169 name: positive regulation of toll-like receptor 10 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR10 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway [Term] id: GO:0034170 name: toll-like receptor 11 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR11 signaling pathway" EXACT [] synonym: "toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034171 name: regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR11 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034170 ! toll-like receptor 11 signaling pathway relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034172 name: negative regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR11 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034173 name: positive regulation of toll-like receptor 11 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR11 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway [Term] id: GO:0034174 name: toll-like receptor 12 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR12 signaling pathway" EXACT [] synonym: "toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034175 name: regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR12 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034174 ! toll-like receptor 12 signaling pathway relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034176 name: negative regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR12 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034177 name: positive regulation of toll-like receptor 12 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR12 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway [Term] id: GO:0034178 name: toll-like receptor 13 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678] synonym: "TLR13 signaling pathway" EXACT [] synonym: "toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0034179 name: regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "regulation of TLR13 signaling pathway" EXACT [] synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034178 ! toll-like receptor 13 signaling pathway relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034180 name: negative regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "negative regulation of TLR13 signaling pathway" EXACT [] synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034181 name: positive regulation of toll-like receptor 13 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] synonym: "positive regulation of TLR13 signaling pathway" EXACT [] synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT [] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway [Term] id: GO:0034182 name: regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034183 name: negative regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034184 name: positive regulation of maintenance of mitotic sister chromatid cohesion namespace: biological_process def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion [Term] id: GO:0034185 name: apolipoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl] is_a: GO:0005515 ! protein binding [Term] id: GO:0034186 name: apolipoprotein A-I binding namespace: molecular_function def: "Interacting selectively and non-covalently with apolipoprotein A-I." [GOC:BHF, GOC:rl] is_a: GO:0034185 ! apolipoprotein binding [Term] id: GO:0034187 name: obsolete apolipoprotein E binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with apolipoprotein E." [GOC:BHF, GOC:rl] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "apolipoprotein E binding" EXACT [] is_obsolete: true replaced_by: GO:0034185 [Term] id: GO:0034188 name: apolipoprotein A-I receptor activity namespace: molecular_function def: "Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:BHF, GOC:rl, GOC:signaling, PMID:16443932] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0030226 ! apolipoprotein receptor activity relationship: has_part GO:0034186 ! apolipoprotein A-I binding relationship: part_of GO:0038027 ! apolipoprotein A-I-mediated signaling pathway [Term] id: GO:0034189 name: very-low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm." [GOC:BHF, GOC:mah] synonym: "very-low-density lipoprotein binding" EXACT [GOC:bf, GOC:dph] synonym: "VLDL binding" EXACT [] is_a: GO:0005515 ! protein binding is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0034190 name: apolipoprotein receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein receptor." [GOC:BHF, GOC:rl] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0034191 name: apolipoprotein A-I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl] comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms. is_a: GO:0034190 ! apolipoprotein receptor binding [Term] id: GO:0034192 name: D-galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah] synonym: "D-galactonate metabolism" EXACT [] is_a: GO:0019583 ! galactonate metabolic process [Term] id: GO:0034193 name: L-galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah] synonym: "L-galactonate metabolism" EXACT [] is_a: GO:0019583 ! galactonate metabolic process [Term] id: GO:0034194 name: D-galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah] synonym: "D-galactonate breakdown" EXACT [] synonym: "D-galactonate catabolism" EXACT [] synonym: "D-galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019584 ! galactonate catabolic process is_a: GO:0034192 ! D-galactonate metabolic process [Term] id: GO:0034195 name: L-galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah] synonym: "L-galactonate breakdown" EXACT [] synonym: "L-galactonate catabolism" EXACT [] synonym: "L-galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019584 ! galactonate catabolic process is_a: GO:0034193 ! L-galactonate metabolic process [Term] id: GO:0034196 name: acylglycerol transport namespace: biological_process def: "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl] synonym: "glyceride transport" EXACT [] is_a: GO:0006869 ! lipid transport [Term] id: GO:0034197 name: triglyceride transport namespace: biological_process def: "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl] synonym: "triacylglycerol transport" EXACT [] is_a: GO:0034196 ! acylglycerol transport [Term] id: GO:0034198 name: cellular response to amino acid starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] synonym: "GAAC response" NARROW [PMID:29596413] synonym: "general amino acid control response" NARROW [PMID:29596413] is_a: GO:0009267 ! cellular response to starvation is_a: GO:1990928 ! response to amino acid starvation [Term] id: GO:0034199 name: activation of protein kinase A activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pde] synonym: "protein kinase A activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0034200 name: D,D-heptose 1,7-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] xref: MetaCyc:RXN0-4361 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0034201 name: response to oleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:lp] synonym: "response to oleate" EXACT [GOC:mah] is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0034202 name: glycolipid floppase activity namespace: molecular_function def: "Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:krc, PMID:11807558] synonym: "ATP-dependent intramembrane glycolipid transporter activity" BROAD [] synonym: "ATPase-coupled intramembrane glycolipid transporter activity" BROAD [] synonym: "glycolipid floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "glycolipid-translocating activity" BROAD [] xref: Reactome:R-HSA-446212 "Flipping of the N-glycan precursor to inside the ER" xref: Reactome:R-HSA-4570573 "Defective RFT1 does not flip the N-glycan precursor" is_a: GO:0140328 ! floppase activity relationship: part_of GO:0034203 ! glycolipid translocation [Term] id: GO:0034203 name: glycolipid translocation namespace: biological_process def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558] is_a: GO:0034204 ! lipid translocation is_a: GO:0046836 ! glycolipid transport [Term] id: GO:0034204 name: lipid translocation namespace: biological_process def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah] synonym: "intramembrane lipid transfer" EXACT [] is_a: GO:0006869 ! lipid transport is_a: GO:0097035 ! regulation of membrane lipid distribution [Term] id: GO:0034205 name: amyloid-beta formation namespace: biological_process def: "The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000). synonym: "beta-amyloid formation" EXACT [] synonym: "beta-amyloid polypeptide formation from amyloid precursor protein" EXACT [] synonym: "beta-amyloid polypeptide formation from APP" EXACT [] is_a: GO:0042987 ! amyloid precursor protein catabolic process is_a: GO:0050435 ! amyloid-beta metabolic process [Term] id: GO:0034206 name: enhanceosome namespace: cellular_component def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024] xref: Wikipedia:Enhanceosome is_a: GO:0032993 ! protein-DNA complex [Term] id: GO:0034207 name: steroid acetylation namespace: biological_process def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034208 name: steroid deacetylation namespace: biological_process def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034209 name: sterol acetylation namespace: biological_process def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0034207 ! steroid acetylation [Term] id: GO:0034210 name: sterol deacetylation namespace: biological_process def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0034208 ! steroid deacetylation [Term] id: GO:0034211 name: GTP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152] is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0034212 name: peptide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] xref: Reactome:R-HSA-3371554 "HSF1 acetylation at Lys80" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0034213 name: quinolinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah] synonym: "quinolinate breakdown" EXACT [] synonym: "quinolinate catabolism" EXACT [] synonym: "quinolinate degradation" EXACT [] is_a: GO:0042737 ! drug catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046874 ! quinolinate metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0034214 name: protein hexamerization namespace: biological_process def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd] synonym: "protein hexamer assembly" EXACT [] synonym: "protein hexamer biosynthesis" EXACT [] synonym: "protein hexamer biosynthetic process" EXACT [] synonym: "protein hexamer formation" EXACT [] is_a: GO:0051259 ! protein complex oligomerization [Term] id: GO:0034215 name: thiamine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)." [GOC:mah] synonym: "thiamin:hydrogen symporter activity" EXACT [] synonym: "thiamin:proton symporter activity" EXACT [] synonym: "thiamine:hydrogen symporter activity" EXACT [] is_a: GO:0015234 ! thiamine transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0034216 name: high-affinity thiamine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity thiamin:hydrogen symporter activity" EXACT [] synonym: "high-affinity thiamin:hydrogen symporter activity" EXACT [] synonym: "high-affinity thiamin:proton symporter activity" EXACT [] synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT [] is_a: GO:0034215 ! thiamine:proton symporter activity [Term] id: GO:0034217 name: ascospore wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] synonym: "ascospore wall chitin anabolism" EXACT [] synonym: "ascospore wall chitin biosynthesis" EXACT [] synonym: "ascospore wall chitin formation" EXACT [] synonym: "ascospore wall chitin synthesis" EXACT [] is_a: GO:0034218 ! ascospore wall chitin metabolic process is_a: GO:0034221 ! fungal-type cell wall chitin biosynthetic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0034218 name: ascospore wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] synonym: "ascospore wall chitin metabolism" EXACT [] is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034220 name: ion transmembrane transport namespace: biological_process alt_id: GO:0099131 def: "A process in which an ion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] synonym: "ion membrane transport" EXACT [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0006811 ! ion transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034221 name: fungal-type cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells." [GOC:mah] synonym: "fungal-type cell wall chitin anabolism" EXACT [] synonym: "fungal-type cell wall chitin biosynthesis" EXACT [] synonym: "fungal-type cell wall chitin formation" EXACT [] synonym: "fungal-type cell wall chitin synthesis" EXACT [] is_a: GO:0006038 ! cell wall chitin biosynthetic process relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0034222 name: regulation of cell wall chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah] synonym: "regulation of cell wall chitin metabolism" EXACT [] is_a: GO:0032882 ! regulation of chitin metabolic process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006037 ! cell wall chitin metabolic process relationship: regulates GO:0006037 ! cell wall chitin metabolic process [Term] id: GO:0034223 name: regulation of ascospore wall chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah] synonym: "regulation of ascospore wall chitin anabolism" EXACT [] synonym: "regulation of ascospore wall chitin biosynthesis" EXACT [] synonym: "regulation of ascospore wall chitin formation" EXACT [] synonym: "regulation of ascospore wall chitin synthesis" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0034307 ! regulation of ascospore formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034217 ! ascospore wall chitin biosynthetic process relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process [Term] id: GO:0034224 name: cellular response to zinc ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah] synonym: "cellular response to zinc ion limitation" EXACT [] synonym: "cellular response to zinc starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0120127 ! response to zinc ion starvation [Term] id: GO:0034225 name: obsolete regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation namespace: biological_process def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah] comment: This entity was obsoleted because it represents a GO-CAM model. synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT [] is_obsolete: true [Term] id: GO:0034227 name: tRNA thio-modification namespace: biological_process def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah] synonym: "tRNA thiolation" EXACT [PMID:24774365] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0034228 name: ethanolamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] synonym: "2-aminoethanol transmembrane transporter activity" EXACT [] synonym: "ethanolamine permease activity" EXACT [] synonym: "monoethanolamine transmembrane transporter activity" EXACT [] xref: RHEA:32747 is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity relationship: part_of GO:0034229 ! ethanolamine transport [Term] id: GO:0034229 name: ethanolamine transport namespace: biological_process def: "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] synonym: "2-aminoethanol transport" EXACT [] synonym: "monoethanolamine transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015837 ! amine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0034230 name: enkephalin processing namespace: biological_process def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946] synonym: "enkephalin formation" EXACT [] synonym: "peptide enkephalin formation" EXACT [] synonym: "peptide enkephalin processing" EXACT [] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0034231 name: islet amyloid polypeptide processing namespace: biological_process def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946] synonym: "IAPP formation" EXACT [] synonym: "IAPP processing" EXACT [] synonym: "islet amyloid peptide formation" EXACT [] synonym: "islet amyloid peptide processing" EXACT [] synonym: "islet amyloid polypeptide formation" RELATED [] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0034232 name: ascospore wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall chitin breakdown" EXACT [] synonym: "ascospore wall chitin catabolism" EXACT [] synonym: "ascospore wall chitin degradation" EXACT [] is_a: GO:0006039 ! cell wall chitin catabolic process is_a: GO:0034218 ! ascospore wall chitin metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0044347 ! cell wall polysaccharide catabolic process is_a: GO:0071854 ! cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly [Term] id: GO:0034233 name: regulation of cell wall chitin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah] synonym: "regulation of cell wall chitin breakdown" EXACT [] synonym: "regulation of cell wall chitin catabolism" EXACT [] synonym: "regulation of cell wall chitin degradation" EXACT [] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006039 ! cell wall chitin catabolic process relationship: regulates GO:0006039 ! cell wall chitin catabolic process [Term] id: GO:0034234 name: regulation of ascospore wall chitin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah] synonym: "regulation of ascospore wall chitin breakdown" EXACT [] synonym: "regulation of ascospore wall chitin catabolism" EXACT [] synonym: "regulation of ascospore wall chitin degradation" EXACT [] is_a: GO:0034233 ! regulation of cell wall chitin catabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0060237 ! regulation of fungal-type cell wall organization is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034232 ! ascospore wall chitin catabolic process relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process [Term] id: GO:0034235 name: GPI anchor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached. synonym: "glycosylphosphatidylinositol binding" EXACT [] is_a: GO:0035091 ! phosphatidylinositol binding is_a: GO:0051861 ! glycolipid binding [Term] id: GO:0034236 name: protein kinase A catalytic subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A." [GOC:mah] synonym: "PKA catalytic subunit binding" EXACT [] is_a: GO:0019901 ! protein kinase binding is_a: GO:0051018 ! protein kinase A binding [Term] id: GO:0034237 name: protein kinase A regulatory subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A." [GOC:mah] synonym: "PKA regulatory subunit binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] is_a: GO:0051018 ! protein kinase A binding [Term] id: GO:0034238 name: macrophage fusion namespace: biological_process def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0034239 name: regulation of macrophage fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034238 ! macrophage fusion relationship: regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034240 name: negative regulation of macrophage fusion namespace: biological_process def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0034239 ! regulation of macrophage fusion is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034238 ! macrophage fusion relationship: negatively_regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034241 name: positive regulation of macrophage fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah] is_a: GO:0034239 ! regulation of macrophage fusion is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034238 ! macrophage fusion relationship: positively_regulates GO:0034238 ! macrophage fusion [Term] id: GO:0034242 name: negative regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0034243 name: regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090039 def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter relationship: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0034244 name: negative regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090041 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter relationship: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0034245 name: mitochondrial DNA-directed RNA polymerase complex namespace: cellular_component def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382] synonym: "mitochondrial RNA polymerase complex" BROAD [] synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT [] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0034246 name: mitochondrial sequence-specific DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000998 alt_id: GO:0001142 alt_id: GO:0001143 alt_id: GO:0001144 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175] comment: Merged terms as discussed in https://github.com/geneontology/go-ontology/issues/14908 synonym: "mitochondrial polymerase transcription factor activity" EXACT [] synonym: "mitochondrial RNA polymerase binding promoter specificity activity" EXACT [] synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "mitochondrial RNA polymerase promoter specificity activity" RELATED [] synonym: "mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding" EXACT [] synonym: "mitochondrial sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "mitochondrial transcription factor activity" RELATED [] synonym: "mitochondrial transcription initiation factor activity" EXACT [] synonym: "sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity" EXACT [] synonym: "transcription factor activity, mitochondrial proximal promoter sequence-specific binding" EXACT [] synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding" EXACT [] synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0003700 ! DNA-binding transcription factor activity intersection_of: GO:0003700 ! DNA-binding transcription factor activity intersection_of: has_part GO:0001001 ! mitochondrial single-subunit type RNA polymerase binding intersection_of: has_part GO:0001018 ! mitochondrial promoter sequence-specific DNA binding relationship: has_part GO:0001001 ! mitochondrial single-subunit type RNA polymerase binding relationship: has_part GO:0001018 ! mitochondrial promoter sequence-specific DNA binding relationship: part_of GO:0006390 ! mitochondrial transcription created_by: kchris creation_date: 2011-01-27T01:55:21Z [Term] id: GO:0034247 name: snoRNA splicing namespace: biological_process def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah] is_a: GO:0008380 ! RNA splicing is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034248 name: regulation of cellular amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043603 ! cellular amide metabolic process relationship: regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034249 name: negative regulation of cellular amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043603 ! cellular amide metabolic process relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034250 name: positive regulation of cellular amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043603 ! cellular amide metabolic process relationship: positively_regulates GO:0043603 ! cellular amide metabolic process [Term] id: GO:0034251 name: regulation of cellular amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043605 ! cellular amide catabolic process relationship: regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034252 name: negative regulation of cellular amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043605 ! cellular amide catabolic process relationship: negatively_regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034253 name: positive regulation of cellular amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0034251 ! regulation of cellular amide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043605 ! cellular amide catabolic process relationship: positively_regulates GO:0043605 ! cellular amide catabolic process [Term] id: GO:0034254 name: regulation of urea catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah] synonym: "regulation of urea breakdown" EXACT [] synonym: "regulation of urea catabolism" EXACT [] synonym: "regulation of urea degradation" EXACT [] is_a: GO:0034251 ! regulation of cellular amide catabolic process is_a: GO:0034255 ! regulation of urea metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043419 ! urea catabolic process relationship: regulates GO:0043419 ! urea catabolic process [Term] id: GO:0034255 name: regulation of urea metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah] synonym: "regulation of urea metabolism" EXACT [] is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019627 ! urea metabolic process relationship: regulates GO:0019627 ! urea metabolic process [Term] id: GO:0034256 name: chlorophyll(ide) b reductase activity namespace: molecular_function def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678] synonym: "Chl b reductase activity" EXACT [] synonym: "chlorophyll b reductase activity" EXACT [] synonym: "chlorophyllide b reductase activity" EXACT [] xref: EC:1.1.1.294 xref: MetaCyc:RXN-7678 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034257 name: nicotinamide riboside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se] xref: RHEA:33163 is_a: GO:0005337 ! nucleoside transmembrane transporter activity relationship: part_of GO:0034258 ! nicotinamide riboside transport [Term] id: GO:0034258 name: nicotinamide riboside transport namespace: biological_process def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:se] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0034260 name: negative regulation of GTPase activity namespace: biological_process alt_id: GO:0034259 alt_id: GO:0034261 alt_id: GO:1902264 alt_id: GO:1902881 def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649] comment: An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649. synonym: "down regulation of GTPase activity" EXACT [] synonym: "down regulation of Rab GTPase activity" NARROW [GOC:pf] synonym: "down regulation of Ras GTPase activity" NARROW [] synonym: "down regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] synonym: "down regulation of Rho GTPase activity" NARROW [] synonym: "down-regulation of GTPase activity" EXACT [] synonym: "down-regulation of Rab GTPase activity" NARROW [GOC:pf] synonym: "down-regulation of Ras GTPase activity" NARROW [] synonym: "down-regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of Rho GTPase activity" NARROW [] synonym: "downregulation of GTPase activity" EXACT [] synonym: "downregulation of Rab GTPase activity" NARROW [GOC:pf] synonym: "downregulation of Ras GTPase activity" NARROW [] synonym: "downregulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] synonym: "downregulation of Rho GTPase activity" NARROW [] synonym: "inhibition of GTPase activity" NARROW [] synonym: "inhibition of Rab GTPase activity" NARROW [GOC:pf] synonym: "inhibition of Ras GTPase activity" NARROW [] synonym: "inhibition of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Rho GTPase activity" NARROW [] synonym: "negative regulation of guanosinetriphosphatase activity" EXACT [] synonym: "negative regulation of Rab GTPase activity" NARROW [] synonym: "negative regulation of Ran GTPase activity" NARROW [] synonym: "negative regulation of Ras GTPase activity" NARROW [] synonym: "negative regulation of Rho GTPase activity" NARROW [] is_a: GO:0043087 ! regulation of GTPase activity is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003924 ! GTPase activity relationship: negatively_regulates GO:0003924 ! GTPase activity [Term] id: GO:0034263 name: positive regulation of autophagy in response to ER overload namespace: biological_process def: "The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy." [GOC:mah] synonym: "autophagy in response to endoplasmic reticulum overload" EXACT [] synonym: "autophagy in response to ER stress" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0010508 ! positive regulation of autophagy intersection_of: GO:0006983 ! ER overload response intersection_of: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0034264 name: isopentenyl adenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] synonym: "isopentenyl adenine metabolism" EXACT [] synonym: "isopentenyladenine metabolic process" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0034265 name: isopentenyl adenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] synonym: "isopentenyl adenine anabolism" EXACT [] synonym: "isopentenyl adenine biosynthesis" EXACT [] synonym: "isopentenyl adenine formation" EXACT [] synonym: "isopentenyl adenine synthesis" EXACT [] synonym: "isopentenyladenine biosynthetic process" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0034264 ! isopentenyl adenine metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0034266 name: isopentenyl adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] synonym: "isopentenyl adenine breakdown" EXACT [] synonym: "isopentenyl adenine catabolism" EXACT [] synonym: "isopentenyl adenine degradation" EXACT [] synonym: "isopentenyladenine catabolic process" EXACT [] is_a: GO:0009823 ! cytokinin catabolic process is_a: GO:0034264 ! isopentenyl adenine metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0034267 name: discadenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] synonym: "discadenine metabolism" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0034268 name: discadenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] synonym: "discadenine anabolism" EXACT [] synonym: "discadenine biosynthesis" EXACT [] synonym: "discadenine formation" EXACT [] synonym: "discadenine synthesis" EXACT [] is_a: GO:0009691 ! cytokinin biosynthetic process is_a: GO:0034267 ! discadenine metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0034269 name: discadenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] synonym: "discadenine breakdown" EXACT [] synonym: "discadenine catabolism" EXACT [] synonym: "discadenine degradation" EXACT [] is_a: GO:0009823 ! cytokinin catabolic process is_a: GO:0034267 ! discadenine metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0034270 name: Cvt complex namespace: cellular_component def: "A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643] synonym: "cytoplasm to vacuole targeting complex" EXACT [] synonym: "cytoplasm-to-vacuole targeting complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034271 name: phosphatidylinositol 3-kinase complex, class III, type I namespace: cellular_component def: "A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex" EXACT [] synonym: "phosphatidylinositol 3-kinase complex I" RELATED [] synonym: "PtdIns-3-kinase complex I" RELATED [] is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III [Term] id: GO:0034272 name: phosphatidylinositol 3-kinase complex, class III, type II namespace: cellular_component def: "A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251] comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. synonym: "phosphatidylinositol 3-kinase complex II" RELATED [] synonym: "PtdIns-3-kinase complex II" RELATED [] is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III [Term] id: GO:0034274 name: Atg12-Atg5-Atg16 complex namespace: cellular_component def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034275 name: kynurenic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah] synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT [] synonym: "kynurenic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0034276 name: kynurenic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah] synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [] synonym: "kynurenic acid anabolism" EXACT [] synonym: "kynurenic acid biosynthesis" EXACT [] synonym: "kynurenic acid formation" RELATED [] synonym: "kynurenic acid synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0034275 ! kynurenic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0034277 name: ent-cassa-12,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [EC:4.2.3.28, RHEA:25532] synonym: "ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity" EXACT systematic_synonym [EC:4.2.3.28, KEGG_REACTION:R09119] xref: EC:4.2.3.28 xref: KEGG_REACTION:R09119 xref: MetaCyc:RXN-4881 xref: RHEA:25532 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034278 name: stemar-13-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882, RHEA:25552] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09115] xref: EC:4.2.3.33 xref: KEGG_REACTION:R09115 xref: MetaCyc:RXN-4882 xref: RHEA:25552 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034279 name: syn-pimara-7,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883, RHEA:25560] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09117] xref: EC:4.2.3.35 xref: KEGG_REACTION:R09117 xref: MetaCyc:RXN-4883 xref: RHEA:25560 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034280 name: ent-sandaracopimaradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [MetaCyc:RXN-4884, RHEA:25536] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09120] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: EC:4.2.3.29 xref: KEGG_REACTION:R09120 xref: MetaCyc:RXN-4884 xref: RHEA:25536 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034281 name: ent-isokaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0034282 name: ent-pimara-8(14),15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate." [RHEA:25540] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09121] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: EC:4.2.3.30 xref: KEGG_REACTION:R09121 xref: MetaCyc:RXN-7788 xref: RHEA:25540 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034283 name: syn-stemod-13(17)-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [RHEA:25556] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09116] synonym: "exo-stemodene synthase activity" EXACT [] synonym: "stemod-13(17)-ene synthase activity" EXACT [] synonym: "stemodene synthase activity" EXACT [] synonym: "syn-stemodene synthase activity" EXACT [] xref: EC:4.2.3.34 xref: KEGG_REACTION:R09116 xref: MetaCyc:RXN-9291 xref: RHEA:25556 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034284 name: response to monosaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0034285 name: response to disaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart] synonym: "response to disaccharide stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0034286 name: response to maltose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart] synonym: "response to maltose stimulus" EXACT [GOC:dos] is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0034287 name: detection of monosaccharide stimulus namespace: biological_process def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah] synonym: "perception of monosaccharide stimulus" RELATED [] is_a: GO:0009730 ! detection of carbohydrate stimulus is_a: GO:0034284 ! response to monosaccharide [Term] id: GO:0034288 name: detection of disaccharide stimulus namespace: biological_process def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart] synonym: "perception of disaccharide stimulus" RELATED [] is_a: GO:0009730 ! detection of carbohydrate stimulus is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0034289 name: detection of maltose stimulus namespace: biological_process def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart] synonym: "perception of maltose stimulus" RELATED [] is_a: GO:0034286 ! response to maltose is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0034290 name: holin activity namespace: molecular_function def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491, PMID:25157079] is_a: GO:0015267 ! channel activity relationship: part_of GO:0044660 ! cytolysis by virus via pore formation in host cell membrane [Term] id: GO:0034291 name: canonical holin activity namespace: molecular_function def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079] is_a: GO:0034290 ! holin activity [Term] id: GO:0034292 name: pinholin activity namespace: molecular_function def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting ion channel activity indirectly allows endolysin (murein hydrolyases) to access their cell wall substrate by collapsing the proton motive force (PMF) across the membrane, allowing the endolysin to fold to an active form and hydrolyze bonds in the peptidoglycan cell wall." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079] is_a: GO:0005216 ! ion channel activity is_a: GO:0034290 ! holin activity [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] subset: goslim_aspergillus synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0043934 ! sporulation intersection_of: GO:0043934 ! sporulation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0019953 ! sexual reproduction relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0034294 name: sexual spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah] synonym: "sexual spore wall formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0034293 ! sexual sporulation [Term] id: GO:0034295 name: basidiospore formation namespace: biological_process def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:di, GOC:ds, GOC:mah, GOC:mcc, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html] comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034296 name: zygospore formation namespace: biological_process def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html] is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034297 name: oidium formation namespace: biological_process def: "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html] is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0034298 name: arthrospore formation namespace: biological_process def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#arthrospore, http://www.ilmyco.gen.chicago.il.us/Terms/arthr620.html] synonym: "arthroconidium formation" EXACT [http://medical.merriam-webster.com/medical/medical?book=Medical&va=arthroconidium] is_a: GO:0048315 ! conidium formation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0034299 name: reproductive blastospore formation namespace: biological_process def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#blastospore, http://bugs.bio.usyd.edu.au/Mycology/Taxonomy/glomeromycota.shtml] comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species. synonym: "blastoconidium formation" EXACT [http://cancerweb.ncl.ac.uk/cgi-bin/omd?Blastoconidium] is_a: GO:0048315 ! conidium formation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0034300 name: sporangiospore formation namespace: biological_process def: "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034301 name: endospore formation namespace: biological_process def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034302 name: akinete formation namespace: biological_process def: "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034303 name: myxospore formation namespace: biological_process def: "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034304 name: actinomycete-type spore formation namespace: biological_process def: "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034305 name: regulation of asexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah] synonym: "regulation of asexual spore formation" EXACT [] synonym: "regulation of mitotic spore formation" EXACT [] synonym: "regulation of mitotic sporulation" EXACT [] is_a: GO:0043937 ! regulation of sporulation is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030436 ! asexual sporulation relationship: regulates GO:0030436 ! asexual sporulation [Term] id: GO:0034306 name: regulation of sexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] synonym: "regulation of meiotic spore formation" EXACT [] synonym: "regulation of meiotic sporulation" EXACT [] synonym: "regulation of sexual spore formation" EXACT [] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034293 ! sexual sporulation relationship: regulates GO:0034293 ! sexual sporulation [Term] id: GO:0034307 name: regulation of ascospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030437 ! ascospore formation relationship: regulates GO:0030437 ! ascospore formation [Term] id: GO:0034308 name: primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol metabolic process" EXACT [] synonym: "primary alcohol metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0034309 name: primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol biosynthetic process" EXACT [] synonym: "primary alcohol anabolism" EXACT [GOC:mah] synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] synonym: "primary alcohol formation" EXACT [GOC:mah] synonym: "primary alcohol synthesis" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0034310 name: primary alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol catabolic process" EXACT [] synonym: "primary alcohol breakdown" EXACT [GOC:mah] synonym: "primary alcohol catabolism" EXACT [GOC:mah] synonym: "primary alcohol degradation" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0034311 name: diol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic." [GOC:curators] synonym: "dihydric alcohol metabolic process" RELATED [] synonym: "diol metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process [Term] id: GO:0034312 name: diol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah] synonym: "dihydric alcohol biosynthetic process" EXACT [] synonym: "diol anabolism" EXACT [] synonym: "diol biosynthesis" EXACT [] synonym: "diol formation" EXACT [] synonym: "diol synthesis" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0034313 name: diol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah] synonym: "dihydric alcohol catabolic process" EXACT [] synonym: "diol breakdown" EXACT [] synonym: "diol catabolism" EXACT [] synonym: "diol degradation" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0034314 name: Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] synonym: "actin filament branch nucleation" EXACT [] synonym: "branched actin filament nucleation" EXACT [] is_a: GO:0045010 ! actin nucleation [Term] id: GO:0034315 name: regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah] is_a: GO:0051125 ! regulation of actin nucleation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation [Term] id: GO:0034316 name: negative regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963] is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation is_a: GO:0051126 ! negative regulation of actin nucleation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation [Term] id: GO:0034317 name: nicotinic acid riboside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide." [PMID:17914902] xref: MetaCyc:RXN-8443 is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0034318 name: alcohol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah] synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW [] synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT [] synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW [] synonym: "AEATase activity" NARROW [] synonym: "alcohol acyltransferase activity" EXACT [] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0034319 name: alcohol O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034323 ! O-butanoyltransferase activity [Term] id: GO:0034320 name: alcohol O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034324 ! O-hexanoyltransferase activity [Term] id: GO:0034321 name: alcohol O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0034322 name: alcohol O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250] is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity is_a: GO:0034325 ! O-decanoyltransferase activity [Term] id: GO:0034323 name: O-butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034326 ! butanoyltransferase activity [Term] id: GO:0034324 name: O-hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034327 ! hexanoyltransferase activity [Term] id: GO:0034325 name: O-decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0034328 ! decanoyltransferase activity [Term] id: GO:0034326 name: butanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034327 name: hexanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034328 name: decanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034329 name: cell junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0034330 ! cell junction organization [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0034331 name: cell junction maintenance namespace: biological_process def: "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0034330 ! cell junction organization is_a: GO:0043954 ! cellular component maintenance [Term] id: GO:0034332 name: adherens junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah] synonym: "adherens junction organisation" EXACT [] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0034333 name: adherens junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah] synonym: "adherens junction formation" EXACT [] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0034332 ! adherens junction organization [Term] id: GO:0034334 name: adherens junction maintenance namespace: biological_process def: "The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah] is_a: GO:0034332 ! adherens junction organization is_a: GO:0045217 ! cell-cell junction maintenance [Term] id: GO:0034335 name: DNA negative supercoiling activity namespace: molecular_function def: "Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase] comment: Note that this term was reinstated from obsolete. synonym: "DNA gyrase activity" RELATED [] synonym: "DNA-gyrase activity" RELATED [] is_a: GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [Term] id: GO:0034336 name: misfolded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192] synonym: "RNA chaperone" RELATED [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0034337 name: RNA folding namespace: biological_process def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192] synonym: "RNA chaperone" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0034338 name: short-chain carboxylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp] synonym: "butyrate esterase activity" NARROW [] synonym: "butyryl esterase activity" NARROW [] synonym: "methylbutyrase activity" NARROW [] synonym: "methylbutyrate esterase activity" NARROW [] synonym: "monobutyrase activity" NARROW [] synonym: "propionyl esterase activity" NARROW [] synonym: "short-chain esterase activity" BROAD [] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0034339 name: obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh] comment: This term was added by GO_REF:0000021. This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand. synonym: "regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] is_obsolete: true consider: GO:0004879 consider: GO:0006357 consider: GO:0030374 consider: GO:0030522 [Term] id: GO:0034340 name: response to type I interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "response to type I IFN" EXACT [] is_a: GO:0034097 ! response to cytokine relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034341 name: response to interferon-gamma namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383] synonym: "response to gamma-interferon" RELATED [] synonym: "response to immune interferon" EXACT [] synonym: "response to type II IFN" BROAD [] synonym: "response to type II interferon" BROAD [] is_a: GO:0034097 ! response to cytokine relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034342 name: response to type III interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] synonym: "response to interferon-lambda" NARROW [] synonym: "response to type III IFN" EXACT [] is_a: GO:0034097 ! response to cytokine relationship: part_of GO:0045087 ! innate immune response [Term] id: GO:0034343 name: type III interferon production namespace: biological_process def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "type III IFN production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0034344 name: regulation of type III interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "regulation of type III IFN production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034343 ! type III interferon production relationship: regulates GO:0034343 ! type III interferon production [Term] id: GO:0034345 name: negative regulation of type III interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "down regulation of type III interferon production" EXACT [] synonym: "down-regulation of type III interferon production" EXACT [] synonym: "downregulation of type III interferon production" EXACT [] synonym: "inhibition of type III interferon production" NARROW [] synonym: "negative regulation of type III IFN production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0034344 ! regulation of type III interferon production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034343 ! type III interferon production relationship: negatively_regulates GO:0034343 ! type III interferon production [Term] id: GO:0034346 name: positive regulation of type III interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "activation of type III interferon production" NARROW [] synonym: "positive regulation of type III IFN production" EXACT [] synonym: "stimulation of type III interferon production" NARROW [] synonym: "up regulation of type III interferon production" EXACT [] synonym: "up-regulation of type III interferon production" EXACT [] synonym: "upregulation of type III interferon production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0034344 ! regulation of type III interferon production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034343 ! type III interferon production relationship: positively_regulates GO:0034343 ! type III interferon production [Term] id: GO:0034347 name: type III interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type III interferon. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda binding" NARROW [] is_a: GO:0019961 ! interferon binding [Term] id: GO:0034348 name: type III interferon receptor activity namespace: molecular_function def: "Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "interferon-lambda receptor activity" NARROW [PR:000001362] is_a: GO:0004904 ! interferon receptor activity relationship: has_part GO:0034347 ! type III interferon binding relationship: part_of GO:0038196 ! type III interferon signaling pathway [Term] id: GO:0034349 name: glial cell apoptotic process namespace: biological_process def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] synonym: "apoptosis of glia" EXACT [] synonym: "apoptosis of glial cells" EXACT [] synonym: "glia apoptosis" EXACT [] synonym: "glia programmed cell death by apoptosis" EXACT [] synonym: "glial cell apoptosis" NARROW [] synonym: "glial cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of glia by apoptosis" EXACT [] synonym: "programmed cell death of glial cells by apoptosis" EXACT [] synonym: "programmed cell death, glia" EXACT [] synonym: "programmed cell death, glial cells" EXACT [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0034350 name: regulation of glial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of glial cell apoptosis" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034349 ! glial cell apoptotic process relationship: regulates GO:0034349 ! glial cell apoptotic process [Term] id: GO:0034351 name: negative regulation of glial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "down regulation of glial cell apoptosis" EXACT [] synonym: "down-regulation of glial cell apoptosis" EXACT [] synonym: "downregulation of glial cell apoptosis" EXACT [] synonym: "inhibition of glial cell apoptosis" NARROW [] synonym: "negative regulation of glial cell apoptosis" NARROW [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034349 ! glial cell apoptotic process relationship: negatively_regulates GO:0034349 ! glial cell apoptotic process [Term] id: GO:0034352 name: positive regulation of glial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "activation of glial cell apoptosis" NARROW [] synonym: "positive regulation of glial cell apoptosis" NARROW [] synonym: "stimulation of glial cell apoptosis" NARROW [] synonym: "up regulation of glial cell apoptosis" EXACT [] synonym: "up-regulation of glial cell apoptosis" EXACT [] synonym: "upregulation of glial cell apoptosis" EXACT [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034349 ! glial cell apoptotic process relationship: positively_regulates GO:0034349 ! glial cell apoptotic process [Term] id: GO:0034353 name: RNA pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0034354 name: 'de novo' NAD biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604] synonym: "de novo NAD biosynthetic process from tryptophan" RELATED [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0034627 ! 'de novo' NAD biosynthetic process [Term] id: GO:0034355 name: NAD salvage namespace: biological_process def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681] synonym: "NAD salvage pathway" EXACT [] is_a: GO:0009435 ! NAD biosynthetic process is_a: GO:0019365 ! pyridine nucleotide salvage [Term] id: GO:0034356 name: NAD biosynthesis via nicotinamide riboside salvage pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543] synonym: "nicotinamide riboside salvage pathway" EXACT [] synonym: "NR salvage pathway" EXACT [] is_a: GO:0009435 ! NAD biosynthetic process [Term] id: GO:0034357 name: photosynthetic membrane namespace: cellular_component def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah] is_a: GO:0016020 ! membrane relationship: part_of GO:0009579 ! thylakoid [Term] id: GO:0034358 name: plasma lipoprotein particle namespace: cellular_component def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl] is_a: GO:1990777 ! lipoprotein particle relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0034359 name: mature chylomicron namespace: cellular_component def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0042627 ! chylomicron [Term] id: GO:0034360 name: chylomicron remnant namespace: cellular_component def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0042627 ! chylomicron [Term] id: GO:0034361 name: very-low-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "very-low-density lipoprotein complex" EXACT [] synonym: "VLDL complex" EXACT [] synonym: "VLDL particle" EXACT [] is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle [Term] id: GO:0034362 name: low-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "LDL complex" EXACT [] synonym: "LDL particle" EXACT [] synonym: "low-density lipoprotein complex" EXACT [] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034363 name: intermediate-density lipoprotein particle namespace: cellular_component def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL complex" EXACT [] synonym: "IDL particle" EXACT [] synonym: "intermediate-density lipoprotein complex" EXACT [] is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle [Term] id: GO:0034364 name: high-density lipoprotein particle namespace: cellular_component def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl] synonym: "HDL complex" EXACT [] synonym: "HDL particle" EXACT [] synonym: "HDL2" RELATED [] synonym: "HDL3" RELATED [] synonym: "high-density lipoprotein class complex" EXACT [] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034365 name: discoidal high-density lipoprotein particle namespace: cellular_component def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "discoidal HDL" EXACT [] synonym: "nascent HDL" EXACT [] synonym: "nascent high-density lipoprotein particle" EXACT [] is_a: GO:0034364 ! high-density lipoprotein particle [Term] id: GO:0034366 name: spherical high-density lipoprotein particle namespace: cellular_component def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "mature HDL" EXACT [] synonym: "mature high-density lipoprotein particle" EXACT [] synonym: "spherical HDL" EXACT [] is_a: GO:0034364 ! high-density lipoprotein particle [Term] id: GO:0034367 name: protein-containing complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl] synonym: "macromolecular complex remodeling" RELATED [] is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0034368 name: protein-lipid complex remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0034367 ! protein-containing complex remodeling is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0034369 name: plasma lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] is_a: GO:0034368 ! protein-lipid complex remodeling is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034370 name: triglyceride-rich lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034371 name: chylomicron remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "chylomicron remnant formation" RELATED [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034372 name: very-low-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL formation" RELATED [] synonym: "intermediate-density lipoprotein particle formation" RELATED [] synonym: "VLDL remodeling" EXACT [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034373 name: intermediate-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "IDL remodeling" EXACT [] synonym: "LDL formation" RELATED [] synonym: "low-density lipoprotein particle formation" RELATED [] is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling [Term] id: GO:0034374 name: low-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "LDL remodeling" EXACT [] synonym: "small dense LDL formation" RELATED [GOC:BHF] synonym: "small dense low-density lipoprotein particle formation" RELATED [GOC:BHF] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034375 name: high-density lipoprotein particle remodeling namespace: biological_process def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] synonym: "HDL remodeling" EXACT [] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034376 name: conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle namespace: biological_process def: "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pde] synonym: "conversion of discoidal HDL to spherical HDL" EXACT [] synonym: "discoidal HDL remodeling" RELATED [] synonym: "discoidal high-density lipoprotein remodeling" RELATED [] is_a: GO:0034375 ! high-density lipoprotein particle remodeling [Term] id: GO:0034377 name: plasma lipoprotein particle assembly namespace: biological_process def: "The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah] is_a: GO:0065005 ! protein-lipid complex assembly is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034378 name: chylomicron assembly namespace: biological_process def: "The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034379 name: very-low-density lipoprotein particle assembly namespace: biological_process def: "The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah] synonym: "VLDL assembly" EXACT [] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034380 name: high-density lipoprotein particle assembly namespace: biological_process def: "The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah] synonym: "HDL assembly" EXACT [] is_a: GO:0034377 ! plasma lipoprotein particle assembly [Term] id: GO:0034381 name: plasma lipoprotein particle clearance namespace: biological_process def: "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb] synonym: "lipoprotein particle clearance" EXACT [GOC:mah] is_a: GO:0032501 ! multicellular organismal process relationship: has_part GO:0006898 ! receptor-mediated endocytosis relationship: has_part GO:0071829 ! plasma lipoprotein particle disassembly relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels [Term] id: GO:0034382 name: chylomicron remnant clearance namespace: biological_process def: "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pde] is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance [Term] id: GO:0034383 name: low-density lipoprotein particle clearance namespace: biological_process def: "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] synonym: "LDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance relationship: has_part GO:0090495 ! low-density lipoprotein particle disassembly [Term] id: GO:0034384 name: high-density lipoprotein particle clearance namespace: biological_process def: "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] synonym: "HDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0034385 name: triglyceride-rich plasma lipoprotein particle namespace: cellular_component def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl] synonym: "triacylglycerol-rich lipoprotein particle" NARROW [GOC:mah] synonym: "triglyceride-rich lipoprotein particle" BROAD [GOC:mah] is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0034386 name: 4-aminobutyrate:2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah] synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19] synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] xref: EC:2.6.1.19 xref: MetaCyc:GABATRANSAM-RXN is_a: GO:0003867 ! 4-aminobutyrate transaminase activity [Term] id: GO:0034387 name: 4-aminobutyrate:pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.96, GOC:mah] synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.96] xref: EC:2.6.1.96 xref: MetaCyc:RXN-6902 is_a: GO:0003867 ! 4-aminobutyrate transaminase activity [Term] id: GO:0034388 name: Pwp2p-containing subcomplex of 90S preribosome namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "25-30 S subcomplex of 90S preribosome" EXACT [] synonym: "UTP-B complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005730 ! nucleolus relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034389 name: lipid droplet organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] comment: Changed term label see https://github.com/geneontology/go-ontology/issues/15963 and https://github.com/geneontology/go-ontology/issues/13534 synonym: "adiposome organization" EXACT [] synonym: "lipid body organization" EXACT [] synonym: "lipid particle organisation" EXACT [] synonym: "lipid particle organization" EXACT [] synonym: "lipid particle organization and biogenesis" BROAD [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0034390 name: smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptosis of smooth muscle cells" EXACT [] synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] synonym: "programmed cell death, smooth muscle cells" EXACT [] synonym: "SMC apoptosis" EXACT [] synonym: "smooth muscle cell apoptosis" NARROW [] synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] is_a: GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0034391 name: regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "regulation of SMC apoptosis" EXACT [] synonym: "regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034390 ! smooth muscle cell apoptotic process relationship: regulates GO:0034390 ! smooth muscle cell apoptotic process [Term] id: GO:0034392 name: negative regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] synonym: "negative regulation of SMC apoptosis" EXACT [] synonym: "negative regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process [Term] id: GO:0034393 name: positive regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "activation of smooth muscle cell apoptosis" NARROW [] synonym: "positive regulation of SMC apoptosis" EXACT [] synonym: "positive regulation of smooth muscle cell apoptosis" NARROW [] synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process [Term] id: GO:0034394 name: protein localization to cell surface namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah] synonym: "protein localisation at cell surface" EXACT [GOC:mah] synonym: "protein localization at cell surface" EXACT [] is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0034395 name: regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah] comment: This term was added by GO_REF:0000021. synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II relationship: part_of GO:0071281 ! cellular response to iron ion [Term] id: GO:0034396 name: negative regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah] synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [] synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron [Term] id: GO:0034397 name: telomere localization namespace: biological_process def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah, GOC:vw] synonym: "telomere localisation" EXACT [GOC:mah] is_a: GO:0050000 ! chromosome localization [Term] id: GO:0034398 name: telomere tethering at nuclear periphery namespace: biological_process def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah] is_a: GO:0034397 ! telomere localization [Term] id: GO:0034399 name: nuclear periphery namespace: cellular_component def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0034400 name: gerontoplast namespace: cellular_component def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876] is_a: GO:0009536 ! plastid [Term] id: GO:0034401 name: chromatin organization involved in regulation of transcription namespace: biological_process alt_id: GO:1903756 alt_id: GO:1903757 def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators, PMID:21102443] synonym: "activation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah] synonym: "regulation of transcription by chromatin organization" EXACT [] synonym: "regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] is_a: GO:0006325 ! chromatin organization intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated created_by: rl creation_date: 2014-12-18T14:56:16Z [Term] id: GO:0034402 name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex namespace: biological_process def: "The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0034403 name: alignment of 3' and 5' splice sites of mRNA namespace: biological_process def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647] synonym: "alignment of 3' and 5' splice sites of nuclear mRNA" EXACT [GOC:vw] is_a: GO:0000389 ! mRNA 3'-splice site recognition is_a: GO:0000395 ! mRNA 5'-splice site recognition relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step [Term] id: GO:0034404 name: nucleobase-containing small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah] synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT [] synonym: "nucleobase, nucleoside and nucleotide formation" EXACT [] synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT [] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0034405 name: response to fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl] is_a: GO:0006950 ! response to stress [Term] id: GO:0034406 name: cell wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall beta-glucan metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0034407 name: cell wall (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-beta-D-glucan metabolic process" EXACT [] synonym: "cell wall 1,3-beta-glucan metabolic process" BROAD [] synonym: "cell wall 1,3-beta-glucan metabolism" EXACT [] synonym: "cell wall beta-1,3 glucan metabolic process" EXACT [] synonym: "cell wall beta-1,3 glucan metabolism" EXACT [] is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process is_a: GO:0034406 ! cell wall beta-glucan metabolic process [Term] id: GO:0034408 name: ascospore wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall beta-glucan metabolism" EXACT [] is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0034409 name: ascospore wall (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-beta-D-glucan metabolic process" EXACT [] synonym: "ascospore wall 1,3-beta-glucan metabolic process" BROAD [] synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process [Term] id: GO:0034410 name: cell wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall beta-glucan anabolism" EXACT [] synonym: "cell wall beta-glucan biosynthesis" EXACT [] synonym: "cell wall beta-glucan formation" EXACT [] synonym: "cell wall beta-glucan synthesis" EXACT [] is_a: GO:0034406 ! cell wall beta-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0034411 name: cell wall (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-beta-D-glucan biosynthetic process" BROAD [] synonym: "cell wall 1,3-beta-glucan anabolism" EXACT [] synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT [] synonym: "cell wall 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "cell wall 1,3-beta-glucan formation" EXACT [] synonym: "cell wall 1,3-beta-glucan synthesis" EXACT [] synonym: "cell wall beta-1,3-glucan anabolism" EXACT [] synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT [] synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT [] synonym: "cell wall beta-1,3-glucan formation" EXACT [] synonym: "cell wall beta-1,3-glucan synthesis" EXACT [] is_a: GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process [Term] id: GO:0034412 name: ascospore wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall beta-glucan anabolism" EXACT [] synonym: "ascospore wall beta-glucan biosynthesis" EXACT [] synonym: "ascospore wall beta-glucan formation" EXACT [] synonym: "ascospore wall beta-glucan synthesis" EXACT [] is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process [Term] id: GO:0034413 name: ascospore wall (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD [] synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT [] synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT [] synonym: "ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "ascospore wall 1,3-beta-glucan formation" EXACT [] synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT [] synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT [] synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT [] synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT [] synonym: "ascospore wall beta-1,3-glucan formation" EXACT [] synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT [] is_a: GO:0034409 ! ascospore wall (1->3)-beta-D-glucan metabolic process is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process is_a: GO:0071970 ! fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process [Term] id: GO:0034414 name: tRNA 3'-trailer cleavage, endonucleolytic namespace: biological_process def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT [] synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED [] synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT [] is_a: GO:0042779 ! tRNA 3'-trailer cleavage is_a: GO:1905267 ! endonucleolytic cleavage involved in tRNA processing [Term] id: GO:0034415 name: tRNA 3'-trailer cleavage, exonucleolytic namespace: biological_process def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT [] synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT [] synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT [] is_a: GO:0042779 ! tRNA 3'-trailer cleavage is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic [Term] id: GO:0034416 name: bisphosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.80, GOC:mah, PMID:18413611] synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [] synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [] synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [] synonym: "diphosphoglycerate phosphatase activity" EXACT [] synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0034417 name: bisphosphoglycerate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate." [EC:3.1.3.80, GOC:mah, PMID:18413611] synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.80] xref: EC:3.1.3.80 xref: KEGG_REACTION:R09532 xref: MetaCyc:RXN-11102 xref: RHEA:27381 is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0034418 name: urate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah] synonym: "urate anabolism" RELATED [] synonym: "urate biosynthesis" EXACT [] synonym: "urate formation" EXACT [] synonym: "urate synthesis" EXACT [] synonym: "uric acid biosynthetic process" EXACT [] is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046415 ! urate metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0034419 name: L-2-hydroxyglutarate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide." [PMID:18390652] is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0034420 name: co-translational protein acetylation namespace: biological_process def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah] synonym: "co-translational protein amino acid acetylation" EXACT [GOC:bf] synonym: "cotranslational protein amino acid acetylation" EXACT [] is_a: GO:0006473 ! protein acetylation is_a: GO:0043686 ! co-translational protein modification [Term] id: GO:0034421 name: post-translational protein acetylation namespace: biological_process def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah] synonym: "post-translational protein amino acid acetylation" EXACT [GOC:bf] synonym: "posttranslational protein amino acid acetylation" EXACT [] is_a: GO:0006473 ! protein acetylation is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0034422 name: aleurone grain lumen namespace: cellular_component def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0033095 ! aleurone grain [Term] id: GO:0034423 name: autophagosome lumen namespace: cellular_component def: "The volume enclosed within the autophagosome double-membrane." [GOC:autophagy, GOC:rph] comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. synonym: "autophagic vacuole lumen" EXACT [GOC:autophagy] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0005776 ! autophagosome [Term] id: GO:0034424 name: Vps55/Vps68 complex namespace: cellular_component def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0034425 name: etioplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0034426 name: etioplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0034425 ! etioplast envelope [Term] id: GO:0034427 name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah] synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic [Term] id: GO:0034428 name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah] synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic [Term] id: GO:0034429 name: tectobulbar tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0034430 name: monolayer-surrounded lipid storage body outer lipid monolayer namespace: cellular_component def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph] synonym: "lipid droplet outer lipid monolayer" RELATED [] synonym: "lipid storage body surface lipid monolayer" EXACT [] synonym: "oil body outer lipid monolayer" EXACT [] synonym: "oleosome outer lipid monolayer" EXACT [] synonym: "spherosome outer lipid monolayer" EXACT [] is_a: GO:0034646 ! organelle-enclosing lipid monolayer relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body [Term] id: GO:0034431 name: bis(5'-adenosyl)-hexaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(6)A hydrolase activity" EXACT [] synonym: "AP-6-A hydrolase activity" EXACT [] synonym: "AP6A hydrolase activity" EXACT [] synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0034432 name: bis(5'-adenosyl)-pentaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(5)A hydrolase activity" EXACT [] synonym: "AP-5-A hydrolase activity" EXACT [] synonym: "AP5A hydrolase activity" EXACT [] synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb] synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0034433 name: steroid esterification namespace: biological_process def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0030258 ! lipid modification [Term] id: GO:0034434 name: sterol esterification namespace: biological_process def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0034433 ! steroid esterification [Term] id: GO:0034435 name: cholesterol esterification namespace: biological_process def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] is_a: GO:0034434 ! sterol esterification [Term] id: GO:0034436 name: glycoprotein transport namespace: biological_process def: "The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0015031 ! protein transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0034437 name: obsolete glycoprotein transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other." [GOC:BHF, GOC:mah, GOC:rl] comment: This term was obsoleted because there is no transmembrane transporter specific for glycoprotein, see https://github.com/geneontology/go-ontology/issues/17130 for details. synonym: "glycoprotein transporter activity" RELATED [] xref: Reactome:R-HSA-1022127 "OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol" is_obsolete: true [Term] id: GO:0034438 name: lipoprotein amino acid oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah] is_a: GO:0018158 ! protein oxidation is_a: GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034439 name: lipoprotein lipid oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:mah] is_a: GO:0034440 ! lipid oxidation is_a: GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034440 name: lipid oxidation namespace: biological_process def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah] is_a: GO:0030258 ! lipid modification is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0034441 name: plasma lipoprotein particle oxidation namespace: biological_process def: "The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids." [GOC:BHF, GOC:mah] synonym: "plasma lipoprotein oxidation" RELATED [GOC:dph] is_a: GO:0034369 ! plasma lipoprotein particle remodeling [Term] id: GO:0034442 name: regulation of lipoprotein oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] is_a: GO:0050746 ! regulation of lipoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042161 ! lipoprotein oxidation relationship: regulates GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034443 name: negative regulation of lipoprotein oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] synonym: "inhibition of lipoprotein oxidation" NARROW [] is_a: GO:0034442 ! regulation of lipoprotein oxidation is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042161 ! lipoprotein oxidation relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation [Term] id: GO:0034444 name: regulation of plasma lipoprotein oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] synonym: "regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034441 ! plasma lipoprotein particle oxidation relationship: regulates GO:0034441 ! plasma lipoprotein particle oxidation [Term] id: GO:0034445 name: negative regulation of plasma lipoprotein oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] synonym: "inhibition of plasma lipoprotein oxidation" NARROW [] synonym: "negative regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph] is_a: GO:0034444 ! regulation of plasma lipoprotein oxidation is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation relationship: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation [Term] id: GO:0034446 name: substrate adhesion-dependent cell spreading namespace: biological_process def: "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732] synonym: "cell spreading during cell substrate adhesion" EXACT [] synonym: "substrate adhesion dependent cell spreading" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0034447 name: very-low-density lipoprotein particle clearance namespace: biological_process def: "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl] synonym: "VLDL clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0034448 name: EGO complex namespace: cellular_component alt_id: GO:0034449 def: "A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Meh1p, and Slm4p." [GOC:dgf, GOC:rb, PMID:15989961, PMID:16732272, PMID:19748353] synonym: "EGO-GSE complex" EXACT [] synonym: "GSE complex" EXACT [] synonym: "GTPase-containing complex for Gap1p sorting in the endosome" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005768 ! endosome relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0034450 name: ubiquitin-ubiquitin ligase activity namespace: molecular_function def: "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] synonym: "E4" EXACT [] xref: Reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1" xref: Reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
" is_a: GO:0061630 ! ubiquitin protein ligase activity [Term] id: GO:0034451 name: centriolar satellite namespace: cellular_component def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0034452 name: dynactin binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0034453 name: microtubule anchoring namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0034454 name: microtubule anchoring at centrosome namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center [Term] id: GO:0034455 name: t-UTP complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:krc, GOC:mah, GOC:vw, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0034456 name: UTP-C complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005730 ! nucleolus relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034457 name: Mpp10 complex namespace: cellular_component def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605] comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005730 ! nucleolus relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0034458 name: 3'-5' RNA helicase activity namespace: molecular_function alt_id: GO:0034459 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'." [GOC:jp] synonym: "3' to 5' RNA helicase activity" EXACT [] synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT [] synonym: "ATP-dependent 3'-5' RNA helicase activity" EXACT [] is_a: GO:0003724 ! RNA helicase activity [Term] id: GO:0034460 name: uropod assembly namespace: biological_process def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah] synonym: "uropod formation" EXACT [GOC:mah] is_a: GO:0032796 ! uropod organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0034461 name: uropod retraction namespace: biological_process def: "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379] is_a: GO:0032796 ! uropod organization [Term] id: GO:0034462 name: small-subunit processome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah] synonym: "small subunit processome assembly" EXACT [] synonym: "SSU processome assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000028 ! ribosomal small subunit assembly [Term] id: GO:0034463 name: 90S preribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions." [GOC:krc, GOC:mah, GOC:tb] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000027 ! ribosomal large subunit assembly relationship: part_of GO:0000028 ! ribosomal small subunit assembly [Term] id: GO:0034464 name: BBSome namespace: cellular_component def: "A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B." [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262] synonym: "Bardet-Biedl syndrome complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005929 ! cilium [Term] id: GO:0034465 name: response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd] is_a: GO:0009636 ! response to toxic substance is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0034466 name: chromaffin granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042583 ! chromaffin granule [Term] id: GO:0034467 name: esterosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an esterosome." [GOC:rph] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0033117 ! esterosome [Term] id: GO:0034468 name: glycosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a glycosome." [GOC:rph] is_a: GO:0005782 ! peroxisomal matrix relationship: part_of GO:0020015 ! glycosome [Term] id: GO:0034469 name: Golgi stack lumen namespace: cellular_component def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah] is_a: GO:0005796 ! Golgi lumen relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0034470 name: ncRNA processing namespace: biological_process def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034471 name: ncRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah] synonym: "ncRNA 5' end processing" EXACT [] is_a: GO:0000966 ! RNA 5'-end processing is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0034472 name: snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] synonym: "snRNA 3' end processing" EXACT [] is_a: GO:0016180 ! snRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0034473 name: U1 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah] synonym: "U1 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034474 name: U2 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah] synonym: "U2 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034475 name: U4 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah] synonym: "U4 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034476 name: U5 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah] synonym: "U5 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034477 name: U6 snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah] synonym: "U6 snRNA 3' end processing" EXACT [] is_a: GO:0034472 ! snRNA 3'-end processing [Term] id: GO:0034478 name: phosphatidylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah] synonym: "phosphatidylglycerol breakdown" EXACT [] synonym: "phosphatidylglycerol catabolism" EXACT [] synonym: "phosphatidylglycerol degradation" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0034479 name: phosphatidylglycerol phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318] is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0034480 name: phosphatidylcholine phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah] synonym: "alpha-toxin" NARROW [EC:3.1.4.3] synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3] synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3] synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3] synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3] synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3] synonym: "phospholipase C, acting on phosphatidylcholine" EXACT [] xref: EC:3.1.4.3 xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: RHEA:10604 is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0034481 name: chondroitin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034482 name: chondroitin 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754] synonym: "chondroitin 2-O-sulphotransferase activity" EXACT [] synonym: "chondroitin 2-sulfotransferase activity" EXACT [] is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0034483 name: heparan sulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034484 name: raffinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] synonym: "raffinose breakdown" EXACT [] synonym: "raffinose catabolism" EXACT [] synonym: "raffinose degradation" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0033530 ! raffinose metabolic process [Term] id: GO:0034485 name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf] xref: MetaCyc:RXN-10036 xref: Reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane" is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar membrane transport" EXACT [] is_a: GO:0007034 ! vacuolar transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0034487 name: vacuolar amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar amino acid membrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport [Term] id: GO:0034488 name: basic amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0034487 ! vacuolar amino acid transmembrane transport is_a: GO:1990822 ! basic amino acid transmembrane transport [Term] id: GO:0034489 name: neutral amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole [Term] id: GO:0034490 name: basic amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah] is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:1990822 ! basic amino acid transmembrane transport [Term] id: GO:0034491 name: neutral amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole [Term] id: GO:0034492 name: hydrogenosome lumen namespace: cellular_component def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0042566 ! hydrogenosome [Term] id: GO:0034493 name: melanosome lumen namespace: cellular_component def: "The volume enclosed by the melanosome membrane." [GOC:rph] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0042470 ! melanosome [Term] id: GO:0034494 name: microneme lumen namespace: cellular_component def: "The volume enclosed by the microneme membrane." [GOC:rph] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0020009 ! microneme [Term] id: GO:0034495 name: protein storage vacuole lumen namespace: cellular_component def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph] is_a: GO:0000330 ! plant-type vacuole lumen relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0034496 name: multivesicular body membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb] synonym: "MVB membrane disassembly" EXACT [] is_a: GO:0030397 ! membrane disassembly relationship: part_of GO:0036257 ! multivesicular body organization [Term] id: GO:0034497 name: protein localization to phagophore assembly site namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS)." [GOC:rb] synonym: "protein localisation to phagophore assembly site" EXACT [GOC:mah] synonym: "protein localization to PAS" EXACT [] synonym: "protein localization to pre-autophagosomal structure" NARROW [] is_a: GO:0034613 ! cellular protein localization relationship: part_of GO:0000045 ! autophagosome assembly [Term] id: GO:0034498 name: early endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb] synonym: "PGE to Golgi transport" EXACT [] synonym: "post-Golgi endosome to Golgi transport" EXACT [] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0034499 name: late endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb] synonym: "prevacuolar endosome to Golgi transport" EXACT [] synonym: "PVE to Golgi transport" EXACT [] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0034501 name: protein localization to kinetochore namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] synonym: "condensin localization to kinetochore" NARROW [] synonym: "protein localisation to kinetochore" EXACT [GOC:mah] is_a: GO:0071459 ! protein localization to chromosome, centromeric region [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle [Term] id: GO:0034503 name: protein localization to nucleolar rDNA repeats namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah] synonym: "condensin localization to nucleolar rDNA repeats" NARROW [] synonym: "protein localisation to nucleolar rDNA repeats" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome relationship: part_of GO:0007000 ! nucleolus organization [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process alt_id: GO:0044744 def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] synonym: "protein targeting to nucleus" RELATED [] is_a: GO:0033365 ! protein localization to organelle creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0034505 name: tooth mineralization namespace: biological_process def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." [GOC:mah, MP:0002817, MSH:D014074] synonym: "tooth calcification" EXACT [] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0042476 ! odontogenesis [Term] id: GO:0034506 name: chromosome, centromeric core domain namespace: cellular_component def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] synonym: "chromosome, centric core region" RELATED [] synonym: "chromosome, centromeric core region" EXACT [GOC:vw] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0034507 name: chromosome, centromeric outer repeat region namespace: cellular_component def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] synonym: "chromosome, centric outer repeat region" RELATED [] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0034508 name: centromere complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "centromere organization" EXACT [GOC:dph, PMID:18923422] synonym: "chromosome, centromeric region assembly" EXACT [GOC:pr] is_a: GO:0051276 ! chromosome organization is_a: GO:0065004 ! protein-DNA complex assembly [Term] id: GO:0034510 name: centromere separation namespace: biological_process def: "The cell cycle process in which centromeres are physically detached from each other during chromosome separation." [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051304 ! chromosome separation relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0034511 name: U3 snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with U3 small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034512 name: box C/D snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with box C/D small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034513 name: box H/ACA snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with box H/ACA small nucleolar RNA." [GOC:mah] is_a: GO:0030515 ! snoRNA binding [Term] id: GO:0034514 name: mitochondrial unfolded protein response namespace: biological_process def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004] synonym: "mtUPR" EXACT [] is_a: GO:0034620 ! cellular response to unfolded protein [Term] id: GO:0034515 name: proteasome storage granule namespace: cellular_component def: "A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:rb, PMID:18504300] synonym: "PSG" EXACT [] is_a: GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0034516 name: response to vitamin B6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug [Term] id: GO:0034517 name: ribophagy namespace: biological_process def: "The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation." [GOC:autophagy, PMID:18391941] is_a: GO:0061912 ! selective autophagy relationship: has_part GO:0032790 ! ribosome disassembly [Term] id: GO:0034518 name: RNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0034519 name: cytoplasmic RNA cap binding complex namespace: cellular_component def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910] is_a: GO:0005845 ! mRNA cap binding complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0034520 name: 2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0772 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0034521 name: 1-naphthoic acid dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0773 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034522 name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0774] xref: UM-BBD_reactionID:r0774 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034523 name: 3-formylsalicylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide." [UM-BBD_reactionID:r0777] xref: UM-BBD_reactionID:r0777 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0034524 name: 2-hydroxyisophthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776] xref: UM-BBD_reactionID:r0776 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034525 name: 1-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787] xref: UM-BBD_reactionID:r0787 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034526 name: 2-methylnaphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0788] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0788 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034527 name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790] xref: UM-BBD_reactionID:r0790 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034528 name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791] xref: EC:5.3.99 xref: UM-BBD_reactionID:r0791 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034529 name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [UM-BBD_reactionID:r0792] xref: EC:4.1.2 xref: UM-BBD_reactionID:r0792 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034530 name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+." [UM-BBD_reactionID:r0767] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0767 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0034531 name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [UM-BBD_reactionID:r0766] xref: EC:4.1.2 xref: UM-BBD_reactionID:r0766 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034532 name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765] xref: EC:5.3.99 xref: UM-BBD_reactionID:r0765 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034533 name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764] xref: UM-BBD_reactionID:r0764 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034534 name: 1-methylnaphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0795 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034535 name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781] xref: UM-BBD_reactionID:r0781 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034536 name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782] xref: EC:5.3.99 xref: UM-BBD_reactionID:r0782 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0034537 name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [UM-BBD_reactionID:r0783] xref: EC:4.1.2 xref: UM-BBD_reactionID:r0783 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0034538 name: 3-methylsalicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784] xref: UM-BBD_reactionID:r0784 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034539 name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0821 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034540 name: 3-monobromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0824 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034541 name: dimethylarsinite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806] xref: UM-BBD_reactionID:r0806 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034542 name: trimethylarsine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0807 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034543 name: 5-aminosalicylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0809 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034544 name: trans-ACOHDA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810] xref: EC:3.5.99 xref: UM-BBD_reactionID:r0810 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034545 name: fumarylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811] xref: EC:3.7.1.20 xref: UM-BBD_reactionID:r0811 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034546 name: 2,4-dichloroaniline reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0819 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034547 name: N-cyclopropylmelamine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825] xref: MetaCyc:RXN-8018 xref: UM-BBD_reactionID:r0825 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034548 name: N-cyclopropylammeline deaminase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826] xref: MetaCyc:RXN-8019 xref: UM-BBD_reactionID:r0826 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034549 name: N-cyclopropylammelide alkylamino hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827] xref: KEGG_REACTION:R06972 xref: MetaCyc:RXN-8020 xref: UM-BBD_reactionID:r0827 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0034550 name: dimethylarsinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0838 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034551 name: mitochondrial respiratory chain complex III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc] is_a: GO:0017062 ! respiratory chain complex III assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly intersection_of: GO:0017062 ! respiratory chain complex III assembly intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0034552 name: respiratory chain complex II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:dgf] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0034553 name: mitochondrial respiratory chain complex II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf] is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly is_a: GO:0034552 ! respiratory chain complex II assembly intersection_of: GO:0034552 ! respiratory chain complex II assembly intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0034554 name: 3,3',5-tribromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0842 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034555 name: 3,3'-dibromobisphenol A reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0844 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034556 name: nitrobenzoate nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849] xref: EC:1.7.1 xref: UM-BBD_reactionID:r0849 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0034557 name: 2-hydroxylaminobenzoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848] synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_reactionID:r0850] xref: MetaCyc:RXN-8848 xref: UM-BBD_reactionID:r0850 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0034558 name: technetium (VII) reductase activity namespace: molecular_function def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859] xref: UM-BBD_reactionID:r0859 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0034559 name: bisphenol A hydroxylase B activity namespace: molecular_function def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860] xref: UM-BBD_reactionID:r0860 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034560 name: bisphenol A hydroxylase A activity namespace: molecular_function def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0861 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034561 name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862] xref: UM-BBD_reactionID:r0862 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034562 name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864] xref: UM-BBD_reactionID:r0864 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034563 name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0867] xref: UM-BBD_reactionID:r0867 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034564 name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866] xref: UM-BBD_reactionID:r0866 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034565 name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872] xref: EC:3.5.99 xref: UM-BBD_reactionID:r0872 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034567 name: chromate reductase activity namespace: molecular_function def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0884 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034568 name: isoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0892 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034569 name: monodemethylisoproturon dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0893] xref: EC:1.17.99 xref: UM-BBD_reactionID:r0893 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034570 name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0894 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034571 name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895] xref: UM-BBD_reactionID:r0895 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034572 name: monodemethylisoproturon dimethylaminedehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0897 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034573 name: didemethylisoproturon amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898] xref: UM-BBD_reactionID:r0898 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034574 name: didemethylisoproturon dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899] xref: EC:1.17.99 xref: UM-BBD_reactionID:r0899 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034575 name: 4-isopropylaniline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901] xref: EC:1.17.99 xref: UM-BBD_reactionID:r0901 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0034576 name: N-isopropylacetanilide amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913] xref: UM-BBD_reactionID:r0913 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034577 name: N-isopropylacetaniline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914] xref: EC:1.14.15 xref: UM-BBD_reactionID:r0914 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034578 name: limonene 8-hydratase activity namespace: molecular_function def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916] xref: UM-BBD_reactionID:r0916 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034579 name: (1-methylpentyl)succinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920] xref: UM-BBD_reactionID:r0920 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0034580 name: 4-methyloctanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924] xref: EC:1.3.99 xref: UM-BBD_reactionID:r0924 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034581 name: 4-methyloct-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925] xref: UM-BBD_reactionID:r0925 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034582 name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926] xref: UM-BBD_reactionID:r0926 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034583 name: 21U-RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] is_a: GO:0003723 ! RNA binding [Term] id: GO:0034584 name: piRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] synonym: "Piwi-associated RNA binding" EXACT [] is_a: GO:0061980 ! regulatory RNA binding [Term] id: GO:0034585 name: 21U-RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] synonym: "21U-RNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034586 name: 21U-RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] synonym: "21U-RNA breakdown" EXACT [] synonym: "21U-RNA catabolism" EXACT [] synonym: "21U-RNA degradation" EXACT [] is_a: GO:0034585 ! 21U-RNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0034587 name: piRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] subset: goslim_drosophila synonym: "piRNA metabolism" EXACT [] synonym: "Piwi-associated RNA metabolic process" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034588 name: piRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] synonym: "piRNA breakdown" EXACT [] synonym: "piRNA catabolism" EXACT [] synonym: "piRNA degradation" EXACT [] synonym: "Piwi-associated RNA catabolic process" EXACT [] is_a: GO:0034587 ! piRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0034589 name: hydroxyproline transport namespace: biological_process def: "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, PMID:14502423] synonym: "4-hydroxyproline transport" EXACT [] synonym: "L-hydroxyproline transport" NARROW [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0034590 name: L-hydroxyproline transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423] synonym: "4-hydroxyproline transmembrane transporter activity" BROAD [] xref: Reactome:R-HSA-6784213 "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix" is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0034589 ! hydroxyproline transport [Term] id: GO:0034591 name: rhoptry lumen namespace: cellular_component def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128] is_a: GO:0043233 ! organelle lumen relationship: part_of GO:0020008 ! rhoptry [Term] id: GO:0034592 name: synaptic vesicle lumen namespace: cellular_component def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph] subset: goslim_synapse is_a: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0008021 ! synaptic vesicle relationship: part_of GO:0008021 ! synaptic vesicle [Term] id: GO:0034593 name: phosphatidylinositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah] synonym: "diphosphoinositide phosphatase activity" RELATED [] synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT [] synonym: "phosphatidylinositol-bisphosphatase activity" RELATED [] synonym: "triphosphoinositide phosphatase activity" RELATED [] synonym: "triphosphoinositide phosphomonoesterase activity" RELATED [] is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity [Term] id: GO:0034594 name: phosphatidylinositol trisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate." [GOC:mah] is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity [Term] id: GO:0034595 name: phosphatidylinositol phosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh] synonym: "phosphoinositide 5-phosphatase activity" EXACT [] synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT [] is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity [Term] id: GO:0034596 name: phosphatidylinositol phosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah] synonym: "inositol 4-phosphatase" NARROW [GOC:rl] synonym: "phosphoinositide 4-phosphatase activity" EXACT [] synonym: "PI(4)P-phosphatase activity" EXACT [GOC:rl] synonym: "PI4P-phosphatase activity" EXACT [GOC:rl] synonym: "PtdIns4P-phosphatase activity" EXACT [GOC:rl] xref: Reactome:R-HSA-1675988 "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane" xref: Reactome:R-HSA-1676124 "PI4P is dephosphorylated to PI by SACM1L at the ER membrane" xref: Reactome:R-HSA-1676133 "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane" xref: Reactome:R-HSA-8849969 "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane" is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity [Term] id: GO:0034597 name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] xref: EC:3.1.3.66 xref: MetaCyc:3.1.3.66-RXN xref: Reactome:R-HSA-6810410 "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus" is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity [Term] id: GO:0034598 name: phosphothreonine lyase activity namespace: molecular_function def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034599 name: cellular response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0062197 ! cellular response to chemical stress [Term] id: GO:0034601 name: oxoglutarate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [EC:1.2.1.52, GOC:mah] xref: EC:1.2.1.52 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034602 name: oxoglutarate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah] xref: EC:1.2.1 xref: KEGG_REACTION:R08549 xref: MetaCyc:2OXOGLUTARATEDEH-RXN xref: Reactome:R-HSA-71037 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+" xref: Reactome:R-HSA-71401 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+" is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity [Term] id: GO:0034603 name: pyruvate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah] is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034604 name: pyruvate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah, ISBN:0201090910] xref: KEGG_REACTION:R00209 xref: MetaCyc:PYRUVDEH-RXN xref: RHEA:28042 is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity relationship: has_part GO:0004148 ! dihydrolipoyl dehydrogenase activity relationship: has_part GO:0004739 ! pyruvate dehydrogenase (acetyl-transferring) activity relationship: has_part GO:0004742 ! dihydrolipoyllysine-residue acetyltransferase activity relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0034605 name: cellular response to heat namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] synonym: "cellular response to heat stress" EXACT [] is_a: GO:0009408 ! response to heat is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0034606 name: response to hermaphrodite contact namespace: biological_process def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034607 name: turning behavior involved in mating namespace: biological_process def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109] synonym: "turning behavior during mating" EXACT [] is_a: GO:0035178 ! turning behavior is_a: GO:0060179 ! male mating behavior intersection_of: GO:0035178 ! turning behavior intersection_of: part_of GO:0007618 ! mating [Term] id: GO:0034608 name: vulval location namespace: biological_process def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034609 name: spicule insertion namespace: biological_process def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467] is_a: GO:0060179 ! male mating behavior [Term] id: GO:0034610 name: oligodeoxyribonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah] synonym: "DNA oligonucleotidase activity" EXACT [] is_a: GO:0004536 ! deoxyribonuclease activity is_a: GO:0008946 ! oligonucleotidase activity [Term] id: GO:0034611 name: oligoribonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah] synonym: "RNA oligonucleotidase activity" EXACT [] xref: Reactome:R-HSA-9009950 "PDE12 cleaves 2'-5' oligoadenylates" xref: Reactome:R-HSA-9615042 "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates" is_a: GO:0004540 ! ribonuclease activity is_a: GO:0008946 ! oligonucleotidase activity [Term] id: GO:0034612 name: response to tumor necrosis factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] synonym: "response to TNF" EXACT [] is_a: GO:0034097 ! response to cytokine [Term] id: GO:0034613 name: cellular protein localization namespace: biological_process alt_id: GO:0016249 def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] subset: goslim_drosophila synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "channel localizer activity" NARROW [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0034614 name: cellular response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] synonym: "cellular response to active oxygen species" EXACT [] synonym: "cellular response to AOS" EXACT [] synonym: "cellular response to reactive oxidative species" EXACT [] synonym: "cellular response to reactive oxygen intermediate" EXACT [] synonym: "cellular response to ROI" EXACT [] synonym: "cellular response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:1901701 ! cellular response to oxygen-containing compound [Term] id: GO:0034615 name: GCH1 complex namespace: cellular_component def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853] synonym: "GTP cyclohydrolase I complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034616 name: response to laminar fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd] is_a: GO:0034405 ! response to fluid shear stress [Term] id: GO:0034617 name: tetrahydrobiopterin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [GOC:BHF, GOC:mah, GOC:rl] synonym: "BH4 binding" EXACT [] synonym: "H4biopterin binding" EXACT [] synonym: "sapropterin binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0034618 name: arginine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:BHF, GOC:rl] synonym: "aminopentanoic acid binding" RELATED [] synonym: "Arg binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding [Term] id: GO:0034620 name: cellular response to unfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER. synonym: "heat shock protein activity" RELATED [] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0035967 ! cellular response to topologically incorrect protein [Term] id: GO:0034622 name: cellular protein-containing complex assembly namespace: biological_process alt_id: GO:0043623 def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl] synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0034624 name: DNA recombinase assembly involved in gene conversion at mating-type locus namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0022414 ! reproductive process intersection_of: GO:0000730 ! DNA recombinase assembly intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0034625 name: fatty acid elongation, monounsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah] is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid [Term] id: GO:0034626 name: fatty acid elongation, polyunsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah] is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid [Term] id: GO:0034627 name: 'de novo' NAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604] synonym: "de novo NAD biosynthetic process" RELATED [] is_a: GO:0009435 ! NAD biosynthetic process [Term] id: GO:0034628 name: 'de novo' NAD biosynthetic process from aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk] synonym: "de novo NAD biosynthetic process from aspartate" RELATED [] is_a: GO:0019355 ! nicotinamide nucleotide biosynthetic process from aspartate is_a: GO:0034627 ! 'de novo' NAD biosynthetic process [Term] id: GO:0034629 name: cellular protein-containing complex localization namespace: biological_process def: "A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular protein complex localisation" EXACT [GOC:mah] synonym: "cellular protein complex localization" RELATED [] synonym: "establishment and maintenance of cellular protein complex localization" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0034613 ! cellular protein localization [Term] id: GO:0034630 name: RITS complex localization namespace: biological_process def: "Any process in which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of RITS complex localization" EXACT [] synonym: "RITS complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization [Term] id: GO:0034631 name: microtubule anchoring at spindle pole body namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116] synonym: "attachment of spindle microtubules to SPB" EXACT [] synonym: "attachment of spindle microtubules to spindle pole body" EXACT [] synonym: "microtubule anchoring at SPB" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center relationship: part_of GO:0007051 ! spindle organization [Term] id: GO:0034632 name: retinol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] synonym: "retinol transporter activity" RELATED [] synonym: "vitamin A1 transporter activity" EXACT [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0034633 ! retinol transport [Term] id: GO:0034633 name: retinol transport namespace: biological_process def: "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] synonym: "vitamin A1 transport" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046865 ! terpenoid transport [Term] id: GO:0034634 name: glutathione transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other." [GOC:mah] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042937 ! tripeptide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0034775 ! glutathione transmembrane transport [Term] id: GO:0034635 name: glutathione transport namespace: biological_process def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0042939 ! tripeptide transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0034636 name: strand invasion involved in gene conversion at mating-type locus namespace: biological_process def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA at the mating-type locus. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This process occurs as part of gene conversion at the mating-type locus." [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0042148 ! strand invasion intersection_of: GO:0042148 ! strand invasion intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0034637 name: cellular carbohydrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0034638 name: phosphatidylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp] synonym: "phosphatidylcholine breakdown" EXACT [] synonym: "phosphatidylcholine catabolism" EXACT [] synonym: "phosphatidylcholine degradation" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0034639 name: L-amino acid efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] synonym: "L-amino acid efflux permease activity" EXACT [] synonym: "L-amino acid export transporter activity" EXACT [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0034640 name: establishment of mitochondrion localization by microtubule attachment namespace: biological_process def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644] synonym: "establishment of mitochondrion localisation by microtubule attachment" EXACT [GOC:mah] synonym: "mitochondrial localization by microtubule attachment" EXACT [] synonym: "mitochondrial migration by microtubule attachment" EXACT [] synonym: "mitochondrion migration by microtubule attachment" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated is_a: GO:0099098 ! microtubule polymerization based movement [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cellular nitrogen compound metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034642 name: mitochondrion migration along actin filament namespace: biological_process def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb] synonym: "mitochondrial migration along microfilament" EXACT [] synonym: "mitochondrial migration, actin-mediated" EXACT [] synonym: "mitochondrion migration along microfilament" EXACT [] synonym: "mitochondrion transport along actin filament" EXACT [] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0051654 ! establishment of mitochondrion localization is_a: GO:0099515 ! actin filament-based transport [Term] id: GO:0034643 name: establishment of mitochondrion localization, microtubule-mediated namespace: biological_process def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah] synonym: "microtubule-mediated mitochondrion localization" EXACT [] synonym: "mitochondrial localization, microtubule-mediated" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0051654 ! establishment of mitochondrion localization [Term] id: GO:0034644 name: cellular response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] synonym: "cellular response to ultraviolet light stimulus" EXACT [] synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] synonym: "cellular response to UV light stimulus" EXACT [] synonym: "cellular response to UV radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV is_a: GO:0071482 ! cellular response to light stimulus [Term] id: GO:0034645 name: cellular macromolecule biosynthetic process namespace: biological_process alt_id: GO:0034961 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cellular macromolecule formation" EXACT [GOC:mah] synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0034646 name: organelle-enclosing lipid monolayer namespace: cellular_component def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0034647 name: histone demethylase activity (H3-trimethyl-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT [] is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) relationship: part_of GO:0034721 ! histone H3-K4 demethylation, trimethyl-H3-K4-specific [Term] id: GO:0034648 name: histone demethylase activity (H3-dimethyl-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT [] is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) [Term] id: GO:0034649 name: histone demethylase activity (H3-monomethyl-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 4) + O2 + FAD + H2O = histone H3 L-lysine (position 4) + H2O2 + formaldehyde + FADH2. This reaction is the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:16223729] synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT [] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) [Term] id: GO:0034650 name: cortisol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl] synonym: "cortisol metabolism" EXACT [] is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process [Term] id: GO:0034651 name: cortisol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl] synonym: "cortisol anabolism" NARROW [] synonym: "cortisol biosynthesis" EXACT [] synonym: "cortisol formation" EXACT [] synonym: "cortisol synthesis" EXACT [] is_a: GO:0006704 ! glucocorticoid biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0034650 ! cortisol metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0034652 name: extrachromosomal circular DNA localization involved in cell aging namespace: biological_process def: "A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging." [GOC:dph, GOC:jp, GOC:tb, PMID:18660802] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA localisation involved in cell aging" EXACT [GOC:mah] synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT [] synonym: "extrachromosomal circular DNA localization during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0034653 name: retinoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah] synonym: "retinoic acid breakdown" EXACT [] synonym: "retinoic acid catabolism" EXACT [] synonym: "retinoic acid degradation" EXACT [] synonym: "vitamin A1 acid catabolic process" EXACT [] is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:0042363 ! fat-soluble vitamin catabolic process is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0034656 name: nucleobase-containing small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah] synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT [] synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT [] is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0034657 name: GID complex namespace: cellular_component def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034658 name: isopropylmalate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of isopropylmalate from one side of a membrane to the other." [GOC:mah] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0034659 ! isopropylmalate transport [Term] id: GO:0034659 name: isopropylmalate transport namespace: biological_process def: "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0034660 name: ncRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah] synonym: "ncRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0034661 name: ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:rb, PMID:18591258] synonym: "ncRNA breakdown" EXACT [] synonym: "ncRNA catabolism" EXACT [] synonym: "ncRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0034662 name: CFTR-NHERF-ezrin complex namespace: cellular_component def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0034663 name: endoplasmic reticulum chaperone complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] synonym: "endoplasmic reticulum network complex" RELATED [] synonym: "ER chaperone complex" EXACT [] synonym: "ER network complex" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0034664 name: Ig heavy chain-bound endoplasmic reticulum chaperone complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] synonym: "Ig heavy chain-bound ER chaperone complex" EXACT [] synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT [] is_a: GO:0101031 ! chaperone complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0034665 name: integrin alpha1-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha1-beta1 integrin complex" EXACT [] synonym: "ITGA1-ITGB1 complex" NARROW [] synonym: "VLA-1 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034666 name: integrin alpha2-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042] synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432] synonym: "VLA-2 complex" EXACT [PMID:3546305] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034667 name: integrin alpha3-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha3-beta1 integrin complex" EXACT [] synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406] synonym: "VLA-3 complex" EXACT [PMID:3546305] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034668 name: integrin alpha4-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha4-beta1 integrin complex" EXACT [] synonym: "ITGA4-ITGB1 complex" NARROW [] synonym: "VLA-4 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034669 name: integrin alpha4-beta7 complex namespace: cellular_component def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042] synonym: "alpha4-beta7 integrin complex" EXACT [] synonym: "ITGA4-ITGB7 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034670 name: chemotaxis to arachidonic acid namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0034671 name: retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh] synonym: "retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development relationship: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development [Term] id: GO:0034672 name: anterior/posterior pattern specification involved in pronephros development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah] synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: part_of GO:0048793 ! pronephros development [Term] id: GO:0034673 name: inhibin-betaglycan-ActRII complex namespace: cellular_component def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0034674 name: integrin alpha5-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha5-beta1 integrin complex" EXACT [] synonym: "ITGA5-ITGB1 complex" NARROW [] synonym: "VLA-5 complex" EXACT [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034675 name: integrin alpha6-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha6-beta1 integrin complex" EXACT [] synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413] synonym: "VLA-6 complex" EXACT [PMID:2649503] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034676 name: integrin alpha6-beta4 complex namespace: cellular_component def: "An integrin complex that comprises one alpha6 subunit and one beta4 subunit." [PMID:12297042] synonym: "alpha6-beta4 integrin complex" EXACT [] synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034677 name: integrin alpha7-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha7-beta1 integrin complex" EXACT [] synonym: "ITGA7-ITGB1 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034678 name: integrin alpha8-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha8-beta1 integrin complex" EXACT [] synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034679 name: integrin alpha9-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha9-beta1 integrin complex" EXACT [] synonym: "ITGA9-ITGB1 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034680 name: integrin alpha10-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha10-beta1 integrin complex" EXACT [] synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034681 name: integrin alpha11-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] synonym: "alpha11-beta1 integrin complex" EXACT [] synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034682 name: integrin alphav-beta1 complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] synonym: "alphav-beta1 integrin complex" EXACT [] synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034683 name: integrin alphav-beta3 complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042] synonym: "alphav-beta3 integrin complex" EXACT [] synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034684 name: integrin alphav-beta5 complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042] synonym: "alphav-beta5 integrin complex" EXACT [] synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034685 name: integrin alphav-beta6 complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042] synonym: "alphav-beta6 integrin complex" EXACT [] synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034686 name: integrin alphav-beta8 complex namespace: cellular_component def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042] synonym: "alphav-beta8 integrin complex" EXACT [] synonym: "ITGAV-ITGB8 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034687 name: integrin alphaL-beta2 complex namespace: cellular_component def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042] synonym: "alphaL-beta2 integrin complex" EXACT [] synonym: "Itgal-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034688 name: integrin alphaM-beta2 complex namespace: cellular_component def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042] synonym: "alphaM-beta2 integrin complex" EXACT [] synonym: "Itgam-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034689 name: integrin alphaX-beta2 complex namespace: cellular_component def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042] synonym: "alphaX-beta2 integrin complex" EXACT [] synonym: "Itgax-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034690 name: integrin alphaD-beta2 complex namespace: cellular_component def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042] synonym: "alphaD-beta2 integrin complex" EXACT [] synonym: "Itgad-Itgb2 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034691 name: integrin alphaE-beta7 complex namespace: cellular_component def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042] synonym: "Itgae-Itgb7 complex" NARROW [] is_a: GO:0008305 ! integrin complex [Term] id: GO:0034692 name: E.F.G complex namespace: cellular_component def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034693 name: U11/U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] synonym: "18S U11/U12 snRNP" NARROW [] synonym: "snRNP U11/U12" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0034694 name: response to prostaglandin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk] synonym: "response to prostaglandin stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0034695 name: response to prostaglandin E namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk] synonym: "response to prostaglandin E stimulus" EXACT [GOC:dos] is_a: GO:0034694 ! response to prostaglandin is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0034696 name: response to prostaglandin F namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk] synonym: "response to prostaglandin F stimulus" EXACT [GOC:dos] is_a: GO:0034694 ! response to prostaglandin [Term] id: GO:0034697 name: response to prostaglandin I namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk] synonym: "response to prostaglandin I stimulus" EXACT [GOC:dos] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0034694 ! response to prostaglandin [Term] id: GO:0034698 name: response to gonadotropin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk] synonym: "response to gonadotropin stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone [Term] id: GO:0034699 name: response to luteinizing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk] synonym: "response to luteinizing hormone stimulus" EXACT [GOC:dos] is_a: GO:0034698 ! response to gonadotropin is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0034700 name: allulose 6-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk] xref: MetaCyc:RXN0-304 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0034701 name: tripeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] xref: EC:3.4.13 xref: MetaCyc:3.4.11.4-RXN is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0034702 name: ion channel complex namespace: cellular_component def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] is_a: GO:1902495 ! transmembrane transporter complex [Term] id: GO:0034703 name: cation channel complex namespace: cellular_component def: "An ion channel complex through which cations pass." [GOC:mah] is_a: GO:0034702 ! ion channel complex [Term] id: GO:0034704 name: calcium channel complex namespace: cellular_component def: "An ion channel complex through which calcium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034705 name: potassium channel complex namespace: cellular_component def: "An ion channel complex through which potassium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034706 name: sodium channel complex namespace: cellular_component def: "An ion channel complex through which sodium ions pass." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0034707 name: chloride channel complex namespace: cellular_component def: "An ion channel complex through which chloride ions pass." [GOC:mah] is_a: GO:0034702 ! ion channel complex [Term] id: GO:0034708 name: methyltransferase complex namespace: cellular_component def: "A protein complex that possesses methyltransferase activity." [GOC:mah] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034709 name: methylosome namespace: cellular_component def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] synonym: "20S methylosome" EXACT [] synonym: "20S methyltransferase complex" EXACT [] is_a: GO:0034708 ! methyltransferase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034710 name: inhibin complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0034711 name: inhibin binding namespace: molecular_function alt_id: GO:0034712 alt_id: GO:0048186 alt_id: GO:0048187 def: "Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah] synonym: "inhibin alpha binding" NARROW [] synonym: "inhibin beta-A binding" NARROW [] synonym: "inhibin beta-B binding" NARROW [] synonym: "inhibin monomer binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0034713 name: type I transforming growth factor beta receptor binding namespace: molecular_function alt_id: GO:0005103 alt_id: GO:0005116 alt_id: GO:0005120 def: "Interacting selectively and non-covalently with a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah] synonym: "babo binding" NARROW [] synonym: "babo ligand" NARROW [] synonym: "baboon binding" NARROW [] synonym: "baboon ligand" NARROW [] synonym: "baboon receptor ligand" NARROW [] synonym: "sax binding" NARROW [] synonym: "sax ligand" NARROW [] synonym: "saxophone binding" NARROW [] synonym: "saxophone ligand" NARROW [] synonym: "TGF-beta type I binding" EXACT [] synonym: "thickveins binding" NARROW [] synonym: "thickveins ligand" NARROW [] synonym: "tkv binding" NARROW [] synonym: "tkv ligand" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta receptor type I binding" EXACT [] synonym: "type I TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0034714 name: type III transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah] synonym: "betaglycan binding" RELATED [] synonym: "TGF-beta type III binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] synonym: "transforming growth factor beta receptor type III binding" EXACT [] synonym: "type IIII TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0034715 name: pICln-Sm protein complex namespace: cellular_component def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] synonym: "6S pICln complex" EXACT [] is_a: GO:0120114 ! Sm-like protein family complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034716 name: Gemin3-Gemin4-Gemin5 complex namespace: cellular_component def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034717 name: Gemin6-Gemin7-unrip complex namespace: cellular_component def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034718 name: SMN-Gemin2 complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] is_a: GO:0090575 ! RNA polymerase II transcription factor complex is_a: GO:0120114 ! Sm-like protein family complex [Term] id: GO:0034719 name: SMN-Sm protein complex namespace: cellular_component def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797. synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0120114 ! Sm-like protein family complex relationship: has_part GO:0032797 ! SMN complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034720 name: histone H3-K4 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah] synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED [] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0034721 name: histone H3-K4 demethylation, trimethyl-H3-K4-specific namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah] synonym: "H3K4 demethylation (me3)" EXACT [] synonym: "histone H3-K4 tridemethylation" RELATED [] is_a: GO:0034720 ! histone H3-K4 demethylation [Term] id: GO:0034722 name: gamma-glutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0034723 name: DNA replication-dependent nucleosome organization namespace: biological_process def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] synonym: "DNA replication-dependent nucleosome organisation" EXACT [] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0034724 name: DNA replication-independent nucleosome organization namespace: biological_process def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629] synonym: "DNA replication-independent nucleosome organisation" EXACT [] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0034725 name: DNA replication-dependent nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] is_a: GO:0006337 ! nucleosome disassembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0034726 name: DNA replication-independent nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes outside the context of DNA replication." [GOC:mah, PMID:17510629] is_a: GO:0006337 ! nucleosome disassembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0034727 name: piecemeal microautophagy of the nucleus namespace: biological_process def: "Degradation of a cell nucleus by lysosomal microautophagy." [GOC:autophagy, GOC:jp, PMID:18701704] synonym: "PMN" EXACT [] is_a: GO:0016237 ! lysosomal microautophagy is_a: GO:0044804 ! autophagy of nucleus relationship: has_part GO:1905690 ! nucleus disassembly [Term] id: GO:0034728 name: nucleosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah] synonym: "nucleosome organisation" EXACT [] is_a: GO:0006325 ! chromatin organization is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0034729 name: histone H3-K79 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se] synonym: "histone H3 K79 methylation" EXACT [] synonym: "histone H3K79me" EXACT [] synonym: "histone lysine H3 K79 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0034730 name: SmD-containing SMN-Sm protein complex namespace: cellular_component def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0034719 ! SMN-Sm protein complex [Term] id: GO:0034731 name: Lsm-containing SMN-Sm protein complex namespace: cellular_component def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408] synonym: "SMN-containing protein complex" BROAD [] is_a: GO:0034719 ! SMN-Sm protein complex [Term] id: GO:0034732 name: transcription factor TFIIIB-alpha complex namespace: cellular_component def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012] is_a: GO:0000126 ! transcription factor TFIIIB complex [Term] id: GO:0034733 name: transcription factor TFIIIB-beta complex namespace: cellular_component def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012] comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans. is_a: GO:0000126 ! transcription factor TFIIIB complex [Term] id: GO:0034734 name: transcription factor TFIIIC1 complex namespace: cellular_component def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501] is_a: GO:0090576 ! RNA polymerase III transcription factor complex relationship: part_of GO:0000127 ! transcription factor TFIIIC complex [Term] id: GO:0034735 name: transcription factor TFIIIC2 complex namespace: cellular_component def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012] is_a: GO:0090576 ! RNA polymerase III transcription factor complex relationship: part_of GO:0000127 ! transcription factor TFIIIC complex [Term] id: GO:0034736 name: cholesterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [EC:2.3.1.26, RHEA:17729] synonym: "ACAT activity" BROAD [EC:2.3.1.26] synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26] synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT [] synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26] synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26] synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26] xref: EC:2.3.1.26 xref: KEGG_REACTION:R01461 xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-8876696 "SOAT1,2 transfer acyl group to CHOL forming CHEST" xref: RHEA:17729 is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034737 name: ergosterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah] is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034738 name: lanosterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah] is_a: GO:0004772 ! sterol O-acyltransferase activity [Term] id: GO:0034739 name: histone deacetylase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24548] is_a: GO:0004407 ! histone deacetylase activity relationship: part_of GO:0070933 ! histone H4 deacetylation [Term] id: GO:0034740 name: TFIIIC-TOP1-SUB1 complex namespace: cellular_component def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958] synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT [] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0034741 name: APC-tubulin-IQGAP1 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "60S APC complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034743 name: APC-IQGAP complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034744 name: APC-IQGAP1-Cdc42 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034745 name: APC-IQGAP1-Rac1 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034746 name: APC-IQGAP1-CLIP-170 complex namespace: cellular_component def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0034748 name: Par3-APC-KIF3A complex namespace: cellular_component def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034749 name: Scrib-APC complex namespace: cellular_component def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "hScrib-APC complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034750 name: Scrib-APC-beta-catenin complex namespace: cellular_component def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "hScrib-APC-beta-catenin complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034751 name: aryl hydrocarbon receptor complex namespace: cellular_component def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497] synonym: "AhR complex" EXACT [] synonym: "AHRC" EXACT [] is_a: GO:0043235 ! receptor complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034752 name: cytosolic aryl hydrocarbon receptor complex namespace: cellular_component def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995] synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED [] synonym: "cytosolic AhR complex" EXACT [] synonym: "cytosolic AHRC" EXACT [] is_a: GO:0034751 ! aryl hydrocarbon receptor complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0034753 name: nuclear aryl hydrocarbon receptor complex namespace: cellular_component def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497] synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED [] synonym: "nuclear AhR complex" EXACT [] synonym: "nuclear AHRC" EXACT [] is_a: GO:0034751 ! aryl hydrocarbon receptor complex intersection_of: GO:0034751 ! aryl hydrocarbon receptor complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034754 name: cellular hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0034755 name: iron ion transmembrane transport namespace: biological_process alt_id: GO:0000040 alt_id: GO:0006827 alt_id: GO:0061839 alt_id: GO:1903874 def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ferrous ion transmembrane transport" NARROW [] synonym: "ferrous iron transmembrane transport" NARROW [] synonym: "high affinity ferrous ion transmembrane transport" NARROW [] synonym: "high affinity iron ion transport" NARROW [] synonym: "high-affinity ferrous ion transmembrane transport" NARROW [] synonym: "high-affinity iron ion transmembrane transport" NARROW [] synonym: "high-affinity iron ion transport" NARROW [] synonym: "iron ion membrane transport" EXACT [] synonym: "iron(2+) transmembrane transport" NARROW [] synonym: "low affinity iron ion transport" NARROW [] synonym: "low-affinity iron ion transmembrane transport" NARROW [] synonym: "low-affinity iron ion transport" NARROW [] synonym: "transmembrane iron transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: vw creation_date: 2015-02-06T11:29:22Z [Term] id: GO:0034756 name: regulation of iron ion transport namespace: biological_process alt_id: GO:1900390 def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of Fe transport" EXACT [] synonym: "regulation of iron import" NARROW [GOC:TermGenie] synonym: "regulation of iron ion import" NARROW [] synonym: "regulation of iron transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006826 ! iron ion transport relationship: regulates GO:0006826 ! iron ion transport created_by: mah creation_date: 2012-04-18T04:00:14Z [Term] id: GO:0034757 name: negative regulation of iron ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of iron ion transport" EXACT [] synonym: "down-regulation of iron ion transport" EXACT [] synonym: "downregulation of iron ion transport" EXACT [] synonym: "inhibition of iron ion transport" NARROW [] synonym: "negative regulation of iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006826 ! iron ion transport relationship: negatively_regulates GO:0006826 ! iron ion transport [Term] id: GO:0034758 name: positive regulation of iron ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of iron ion transport" NARROW [] synonym: "positive regulation of iron transport" EXACT [] synonym: "stimulation of iron ion transport" NARROW [] synonym: "up regulation of iron ion transport" EXACT [] synonym: "up-regulation of iron ion transport" EXACT [] synonym: "upregulation of iron ion transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006826 ! iron ion transport relationship: positively_regulates GO:0006826 ! iron ion transport [Term] id: GO:0034759 name: regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of iron ion membrane transport" EXACT [] synonym: "regulation of transmembrane Fe transport" EXACT [] synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "regulation of transmembrane iron transport" EXACT [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034755 ! iron ion transmembrane transport relationship: regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034760 name: negative regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of transmembrane iron ion transport" EXACT [] synonym: "down-regulation of transmembrane iron ion transport" EXACT [] synonym: "downregulation of transmembrane iron ion transport" EXACT [] synonym: "inhibition of transmembrane iron ion transport" NARROW [] synonym: "negative regulation of iron ion membrane transport" EXACT [] synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane iron transport" EXACT [] is_a: GO:0034757 ! negative regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034755 ! iron ion transmembrane transport relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034761 name: positive regulation of iron ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of transmembrane iron ion transport" NARROW [] synonym: "positive regulation of iron ion membrane transport" EXACT [] synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane iron transport" EXACT [] synonym: "stimulation of transmembrane iron ion transport" NARROW [] synonym: "up regulation of transmembrane iron ion transport" EXACT [] synonym: "up-regulation of transmembrane iron ion transport" EXACT [] synonym: "upregulation of transmembrane iron ion transport" EXACT [] is_a: GO:0034758 ! positive regulation of iron ion transport is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034755 ! iron ion transmembrane transport relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "regulation of membrane transport" EXACT [] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055085 ! transmembrane transport relationship: regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] synonym: "negative regulation of membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055085 ! transmembrane transport relationship: negatively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "positive regulation of membrane transport" EXACT [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055085 ! transmembrane transport relationship: positively_regulates GO:0055085 ! transmembrane transport [Term] id: GO:0034765 name: regulation of ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of ion membrane transport" EXACT [] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034220 ! ion transmembrane transport relationship: regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of ion membrane transport" EXACT [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034220 ! ion transmembrane transport relationship: negatively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of ion membrane transport" EXACT [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034220 ! ion transmembrane transport relationship: positively_regulates GO:0034220 ! ion transmembrane transport [Term] id: GO:0034768 name: (E)-beta-ocimene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [EC:4.2.3.106, PMID:12624761] xref: EC:4.2.3.106 xref: MetaCyc:RXN-5109 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0034769 name: basement membrane disassembly namespace: biological_process alt_id: GO:0060881 def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. synonym: "basal lamina disassembly" RELATED [] is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0071711 ! basement membrane organization created_by: dph creation_date: 2009-08-13T11:27:24Z [Term] id: GO:0034770 name: histone H4-K20 methylation namespace: biological_process def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 methylation" EXACT [] synonym: "histone H4K20me" EXACT [] synonym: "histone lysine H4 K20 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0034771 name: histone H4-K20 monomethylation namespace: biological_process def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 monomethylation" EXACT [] synonym: "histone lysine H4 K20 monomethylation" EXACT [] is_a: GO:0018026 ! peptidyl-lysine monomethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034772 name: histone H4-K20 dimethylation namespace: biological_process def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 dimethylation" EXACT [] synonym: "histone lysine H4 K20 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034773 name: histone H4-K20 trimethylation namespace: biological_process def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 trimethylation" EXACT [] synonym: "histone lysine H4 K20 trimethylation" EXACT [] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0034774 name: secretory granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a secretory granule." [GOC:rph] is_a: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0030141 ! secretory granule relationship: part_of GO:0030141 ! secretory granule [Term] id: GO:0034775 name: glutathione transmembrane transport namespace: biological_process def: "A process in which glutathione is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "glutathione membrane transport" EXACT [] synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034635 ! glutathione transport is_a: GO:0035443 ! tripeptide transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0034776 name: response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:BHF, GOC:mah, GOC:vk] synonym: "response to histamine stimulus" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0060359 ! response to ammonium ion [Term] id: GO:0034777 name: recycling endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0055037 ! recycling endosome [Term] id: GO:0034778 name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003] xref: UM-BBD_reactionID:r1003 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034779 name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004] xref: UM-BBD_reactionID:r1004 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034780 name: glyphosate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-." [UM-BBD_reactionID:r0073] xref: UM-BBD_reactionID:r0073 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034781 name: N-cyclohexylformamide amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030] xref: UM-BBD_reactionID:r1030 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034782 name: dimethylmalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031] xref: UM-BBD_reactionID:r1031 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034783 name: pivalate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032] xref: UM-BBD_reactionID:r1032 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034784 name: pivalyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033] xref: EC:5.4.99 xref: UM-BBD_reactionID:r1033 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034785 name: salicylate 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034] xref: EC:1.14.13 xref: MetaCyc:RXN-10446 xref: UM-BBD_reactionID:r1034 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034786 name: 9-fluorenone-3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039] xref: UM-BBD_reactionID:r1039 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034787 name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040] xref: UM-BBD_reactionID:r1040 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034788 name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041] xref: UM-BBD_reactionID:r1041 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0034789 name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042] xref: UM-BBD_reactionID:r1042 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034790 name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043] xref: UM-BBD_reactionID:r1043 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034791 name: isobutylamine N-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O." [UM-BBD_reactionID:r1053] xref: EC:1.14.13 xref: UM-BBD_reactionID:r1053 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034792 name: hypophosphite dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058] xref: EC:1.14.11 xref: UM-BBD_reactionID:r1058 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0034793 name: cyclopropanecarboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056] xref: UM-BBD_reactionID:r1056 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034794 name: cyclopropanecarboxyl-CoA decyclase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057] xref: EC:5.5.1 xref: UM-BBD_reactionID:r1057 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0034795 name: cyclohexane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059] synonym: "butane monooxygenase activity" RELATED [] synonym: "cyclohexane hydroxylase activity" EXACT [MetaCyc:RXN-8697] xref: EC:1.14.15 xref: KEGG_REACTION:R06945 xref: MetaCyc:RXN-8697 xref: UM-BBD_reactionID:r1059 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034796 name: adipate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060] xref: UM-BBD_reactionID:r1060 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034797 name: fosfomycin 2-glutathione ligase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073] xref: UM-BBD_reactionID:r1073 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0034798 name: fosfomycin 2-L-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074] xref: UM-BBD_reactionID:r1074 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0034799 name: dihydride TNP tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070] xref: UM-BBD_reactionID:r1070 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0034800 name: trinitrophenol dihydride denitratase activity namespace: molecular_function def: "Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP." [UM-BBD_reactionID:r1067] synonym: "2,4,6-trinitrophenol dihydride denitratase activity" EXACT [] synonym: "TNP dihydride denitratase activity" EXACT [] xref: EC:1.7.99 xref: UM-BBD_reactionID:r1067 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0034801 name: 2,4-dinitrocyclohexanone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069] xref: UM-BBD_reactionID:r1069 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034802 name: branched-chain dodecylbenzene sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite." [UM-BBD_reactionID:r1079] xref: EC:1.14.13 xref: UM-BBD_reactionID:r1079 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034803 name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1104 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034804 name: benzo(a)pyrene 11,12-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119] xref: EC:1.14.99 xref: UM-BBD_reactionID:r1119 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034805 name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121] xref: UM-BBD_reactionID:r1121 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034806 name: benzo(a)pyrene 11,12-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1124 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034807 name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131] xref: UM-BBD_reactionID:r1131 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034808 name: benzo(a)pyrene 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1126 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034809 name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127] xref: UM-BBD_reactionID:r1127 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034810 name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1128 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034811 name: benzo(a)pyrene 9,10-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1132 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034812 name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1134 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034813 name: benzo(a)pyrene 7,8-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1137 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034814 name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1138 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034815 name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135] xref: EC:4.1.3 xref: UM-BBD_reactionID:r1135 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034816 name: anthracene 9,10-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141] xref: UM-BBD_reactionID:r1141 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034817 name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144] xref: UM-BBD_reactionID:r1144 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034818 name: ADD 9alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149] xref: EC:1.14.15 xref: UM-BBD_reactionID:r1149 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034819 name: 3-HSA hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150] xref: EC:1.14.13 xref: UM-BBD_reactionID:r1150 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034820 name: 4,9-DSHA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152] xref: UM-BBD_reactionID:r1152 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034821 name: citronellol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155] xref: UM-BBD_reactionID:r1155 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034822 name: citronellal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156] xref: UM-BBD_reactionID:r1156 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034823 name: citronellyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157] xref: KEGG_REACTION:R08088 xref: UM-BBD_reactionID:r1157 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034824 name: citronellyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159] xref: UM-BBD_reactionID:r1159 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034825 name: tetralin ring-hydroxylating dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169] xref: EC:1.14.12 xref: UM-BBD_reactionID:r1169 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034826 name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170] xref: UM-BBD_reactionID:r1170 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034827 name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1171 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034828 name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172] xref: UM-BBD_reactionID:r1172 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034829 name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172] xref: UM-BBD_reactionID:r1172 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034830 name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174] xref: EC:4.1.3 xref: UM-BBD_reactionID:r1174 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034831 name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176] xref: UM-BBD_reactionID:r1176 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034832 name: geranial dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164] xref: UM-BBD_reactionID:r1164 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0034833 name: geranylate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165] xref: UM-BBD_reactionID:r1165 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034834 name: 2-mercaptobenzothiazole dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol." [UM-BBD_reactionID:r1177] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1177 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034835 name: 2-mercaptobenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178] xref: EC:1.13.12 xref: UM-BBD_reactionID:r1178 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034836 name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181] xref: EC:1.13.12 xref: UM-BBD_reactionID:r1181 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034837 name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179] xref: UM-BBD_reactionID:r1179 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034838 name: menthone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183] xref: UM-BBD_reactionID:r1183 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034839 name: menth-2-enone hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184] xref: UM-BBD_reactionID:r1184 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034840 name: 3-hydroxymenthone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185] xref: UM-BBD_reactionID:r1185 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0034841 name: mentha-1,3-dione-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186] xref: UM-BBD_reactionID:r1186 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034842 name: thiophene-2-carboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1234] xref: UM-BBD_reactionID:r1234 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034843 name: 2-oxoglutaryl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238] xref: UM-BBD_reactionID:r1238 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034844 name: naphthyl-2-methyl-succinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256] xref: UM-BBD_reactionID:r1256 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034845 name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258] xref: EC:1.3.99 xref: UM-BBD_reactionID:r1258 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034846 name: naphthyl-2-methylene-succinyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259] xref: UM-BBD_reactionID:r1259 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034847 name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260] xref: UM-BBD_reactionID:r1260 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034848 name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261] xref: UM-BBD_reactionID:r1261 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034849 name: 2-naphthoate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262] xref: UM-BBD_reactionID:r1262 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0034850 name: isooctane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269] xref: EC:1.13.12 xref: UM-BBD_reactionID:r1269 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034851 name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274] xref: UM-BBD_reactionID:r1274 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034852 name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309] xref: UM-BBD_reactionID:r1309 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0034853 name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278] xref: UM-BBD_reactionID:r1278 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034854 name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280] xref: UM-BBD_reactionID:r1280 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034855 name: 4-AD 9alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153] xref: EC:1.14.15 xref: UM-BBD_reactionID:r1153 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034856 name: 2-hydroxyhexa-2,4-dienoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281] xref: EC:4.2.1.132 xref: RHEA:32535 xref: UM-BBD_reactionID:r1281 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034857 name: 2-(methylthio)benzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287] xref: UM-BBD_reactionID:r1287 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034858 name: 2-hydroxybenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291] xref: UM-BBD_reactionID:r1291 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034859 name: benzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292] xref: UM-BBD_reactionID:r1292 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034860 name: 2-mercaptobenzothiazole desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor." [UM-BBD_reactionID:r1288] xref: EC:4.4.1 xref: UM-BBD_reactionID:r1288 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0034861 name: benzothiazole-2-sulfonate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-." [UM-BBD_reactionID:r1290] xref: EC:3.13.1 xref: UM-BBD_reactionID:r1290 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0034862 name: 2,6-dihydroxybenzothiazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294] xref: UM-BBD_reactionID:r1294 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034863 name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1270] xref: UM-BBD_reactionID:r1270 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034864 name: 2,4,4-trimethylpentanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275] xref: UM-BBD_reactionID:r1275 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0034865 name: 2,4,4-trimethylpentanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271] xref: UM-BBD_reactionID:r1271 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034866 name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1276] xref: UM-BBD_reactionID:r1276 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034867 name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277] xref: UM-BBD_reactionID:r1277 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034868 name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1273] xref: UM-BBD_reactionID:r1273 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034869 name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307] xref: UM-BBD_reactionID:r1307 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034870 name: pinacolone 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979] xref: UM-BBD_reactionID:r12979 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034871 name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308] xref: UM-BBD_reactionID:r1308 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034872 name: trans-geranyl-CoA isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310] xref: EC:5.2.1 xref: UM-BBD_reactionID:r1310 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0034873 name: thioacetamide S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312] xref: UM-BBD_reactionID:r1312 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034874 name: thioacetamide S-oxide S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313] xref: UM-BBD_reactionID:r1313 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034875 name: caffeine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [UM-BBD_reactionID:r1321] xref: EC:1.17.5 xref: UM-BBD_reactionID:r1321 is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [Term] id: GO:0034876 name: isonicotinic acid hydrazide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336] xref: UM-BBD_reactionID:r1336 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034877 name: isonicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337] xref: UM-BBD_reactionID:r1337 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034878 name: 2-hydroxyisonicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338] xref: UM-BBD_reactionID:r1338 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034879 name: 2,3,6-trihydroxyisonicotinate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340] xref: UM-BBD_reactionID:r1340 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034880 name: citrazinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339] xref: UM-BBD_reactionID:r1339 is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0034881 name: citrazinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343] xref: UM-BBD_reactionID:r1343 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0034882 name: cis-aconitamide amidase activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344] xref: UM-BBD_reactionID:r1344 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034883 name: obsolete isonicotinate reductase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "isonicotinate reductase activity" EXACT [] is_obsolete: true consider: GO:0016627 [Term] id: GO:0034884 name: obsolete gamma-N-formylaminovinylacetaldehyde dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "gamma-N-formylaminovinylacetaldehyde dehydrogenase activity" EXACT [] is_obsolete: true consider: GO:0016903 [Term] id: GO:0034885 name: gamma-N-formylaminovinylacetate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH." [UM-BBD_reactionID:r1350] xref: UM-BBD_reactionID:r1350 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0034886 name: gamma-aminovinylacetate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351] xref: EC:3.5.99 xref: UM-BBD_reactionID:r1351 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034887 name: obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "1,4-dihydroisonicotinate 2,3-dioxygenase activity" EXACT [] is_obsolete: true consider: GO:0016702 [Term] id: GO:0034888 name: endosulfan monooxygenase I activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382] xref: UM-BBD_reactionID:r1382 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034889 name: endosulfan hemisulfate sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate." [UM-BBD_reactionID:r1384] xref: UM-BBD_reactionID:r1384 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0034890 name: endosulfan diol hydrolyase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386] xref: UM-BBD_reactionID:r1386 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034891 name: endosulfan diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388] xref: UM-BBD_reactionID:r1388 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034892 name: endosulfan lactone lactonase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389] xref: UM-BBD_reactionID:r1389 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0034893 name: N-nitrodimethylamine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395] xref: UM-BBD_reactionID:r1395 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034894 name: 4-hydroxypyridine-3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+." [UM-BBD_reactionID:r1397] xref: EC:1.14.13 xref: UM-BBD_reactionID:r1397 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034895 name: pyridine-3,4-diol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1398 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034896 name: 3-formiminopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400] xref: EC:3.5.99 xref: UM-BBD_reactionID:r1400 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034897 name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358] xref: UM-BBD_reactionID:r1358 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034898 name: hexadecyltrimethylammonium chloride monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373] xref: EC:1.13.12 xref: UM-BBD_reactionID:r1373 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0034899 name: trimethylamine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O." [EC:1.14.13.148, UM-BBD_reactionID:r1407] xref: EC:1.14.13.148 xref: KEGG_REACTION:R05623 xref: RHEA:31979 xref: UM-BBD_reactionID:r1407 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034900 name: 3-(N-formyl)-formiminopyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399] xref: EC:3.5.99 xref: UM-BBD_reactionID:r1399 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034901 name: endosulfan hydroxyether dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411] xref: UM-BBD_reactionID:r1411 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034902 name: endosulfan sulfate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite." [UM-BBD_reactionID:r1387] xref: UM-BBD_reactionID:r1387 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0034903 name: endosulfan ether monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413] xref: UM-BBD_reactionID:r1413 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034904 name: 5-chloro-2-oxopent-4-enoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436] xref: UM-BBD_reactionID:r1436 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034905 name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437] xref: EC:4.1.3 xref: UM-BBD_reactionID:r1437 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0034906 name: N-isopropylaniline 1,2-dixoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0721 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034907 name: acetanilide 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0723 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034908 name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0724 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034909 name: 6-hydroxypseudooxynicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441] xref: EC:1.5.99.14 xref: UM-BBD_reactionID:r1441 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0034910 name: 6-hydroxy-3-succinoylpyridine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442] xref: UM-BBD_reactionID:r1442 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034911 name: phthalate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+." [UM-BBD_reactionID:r1444] xref: EC:1.14.12 xref: UM-BBD_reactionID:r1444 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034912 name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445] xref: MetaCyc:RXN5F9-56 xref: UM-BBD_reactionID:r1445 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0034914 name: trinitrophenol hydride denitratase activity namespace: molecular_function def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP." [UM-BBD_reactionID:r1448] synonym: "2,4,6-trinitrophenol hydride denitratase activity" EXACT [] synonym: "TNP hydride denitratase activity" EXACT [] xref: EC:1.7.99 xref: UM-BBD_reactionID:r1448 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0034915 name: 2-methylhexanoyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927] xref: EC:2.3.1 xref: UM-BBD_reactionID:r0927 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034916 name: 2-methylhexanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928] xref: EC:1.3.99 xref: UM-BBD_reactionID:r0928 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034917 name: 2-methylhex-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929] xref: UM-BBD_reactionID:r0929 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034918 name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930] xref: UM-BBD_reactionID:r0930 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034919 name: butyryl-CoA 2-C-propionyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931] xref: UM-BBD_reactionID:r0931 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034920 name: pyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0934 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034921 name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935] xref: UM-BBD_reactionID:r0935 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034922 name: 4,5-dihydroxypyrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0936 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034923 name: phenanthrene-4,5-dicarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937] xref: UM-BBD_reactionID:r0937 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034924 name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940] xref: UM-BBD_reactionID:r0940 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0034925 name: pyrene 4,5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941] xref: UM-BBD_reactionID:r0941 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034926 name: pyrene-4,5-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942] xref: UM-BBD_reactionID:r0942 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0034927 name: pyrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943] xref: UM-BBD_reactionID:r0943 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034928 name: 1-hydroxypyrene 6,7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946] xref: UM-BBD_reactionID:r0946 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034929 name: 1-hydroxypyrene 7,8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949] xref: UM-BBD_reactionID:r0949 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034930 name: 1-hydroxypyrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX." [UM-BBD_reactionID:r0952] xref: UM-BBD_reactionID:r0952 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0034931 name: 1-hydroxypyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953] xref: UM-BBD_reactionID:r0953 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034932 name: 1-methoxypyrene 6,7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954] xref: UM-BBD_reactionID:r0954 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034933 name: 1-hydroxy-6-methoxypyrene methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956] xref: UM-BBD_reactionID:r0956 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0034934 name: phenanthrene-4-carboxylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0939 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034935 name: tetrachlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0957 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034936 name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0959 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034937 name: perchlorate reductase activity namespace: molecular_function def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0980 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034938 name: pyrrole-2-carboxylate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968] xref: EC:1.14.14 xref: UM-BBD_reactionID:r0968 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0034939 name: 5-hydroxypyrrole-2-carboxylate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969] xref: UM-BBD_reactionID:r0969 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0034940 name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984] xref: UM-BBD_reactionID:r0984 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0034941 name: pyrrole-2-carboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970] xref: EC:4.1.1.93 xref: UM-BBD_reactionID:r0970 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034942 name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988] xref: UM-BBD_reactionID:r0988 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034943 name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989] xref: UM-BBD_reactionID:r0989 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0034944 name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986] xref: UM-BBD_reactionID:r0986 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0034945 name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987] xref: EC:2.3.1 xref: UM-BBD_reactionID:r0987 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0034946 name: 3-isopropylbut-3-enoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994] xref: UM-BBD_reactionID:r0994 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0034947 name: terephthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321] xref: UM-BBD_reactionID:r0321 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034948 name: 2,6-dihydroxypseudooxynicotine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482] xref: EC:3.7.1 xref: UM-BBD_reactionID:r0482 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0034949 name: 1,1-dichloroethane reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008] xref: EC:1.97.1 xref: UM-BBD_reactionID:r1008 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0034950 name: phenylboronic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020] xref: UM-BBD_reactionID:r1020 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0034951 name: o-hydroxylaminobenzoate mutase activity namespace: molecular_function def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026] xref: EC:5.4.99 xref: MetaCyc:RXN-8846 xref: UM-BBD_reactionID:r1026 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0034952 name: malonate semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266] xref: UM-BBD_reactionID:r0266 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0034953 name: perillyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002] xref: UM-BBD_reactionID:r1002 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0034954 name: diphenyl ether 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450] xref: EC:1.14.12 xref: UM-BBD_reactionID:r1450 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0034955 name: 2,3-dihydroxydiphenyl ether dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1451 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034956 name: diphenyl ether 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453] xref: EC:1.13.11 xref: UM-BBD_reactionID:r1453 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0034957 name: 3-nitrophenol nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495] xref: UM-BBD_reactionID:r1495 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0034958 name: aminohydroquinone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497] xref: EC:3.5.99 xref: UM-BBD_reactionID:r1497 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0034959 name: endothelin maturation namespace: biological_process def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl] comment: Term subclasses discussed in https://github.com/geneontology/go-ontology/issues/15384 is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0003100 ! regulation of systemic arterial blood pressure by endothelin [Term] id: GO:0034963 name: box C/D snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA." [GOC:mah] is_a: GO:0033967 ! box C/D snoRNA metabolic process is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034964 name: box H/ACA snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah] is_a: GO:0033979 ! box H/ACA snoRNA metabolic process is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0034965 name: intronic box C/D snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:mah] is_a: GO:0031070 ! intronic snoRNA processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0034966 name: intronic box H/ACA snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah] is_a: GO:0031070 ! intronic snoRNA processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0034967 name: Set3 complex namespace: cellular_component def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] synonym: "HDAC3 complex" EXACT [] synonym: "SET3C" EXACT [] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0034968 name: histone lysine methylation namespace: biological_process def: "The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr] is_a: GO:0016571 ! histone methylation is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0034969 name: histone arginine methylation namespace: biological_process def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah] is_a: GO:0016571 ! histone methylation is_a: GO:0018216 ! peptidyl-arginine methylation [Term] id: GO:0034970 name: histone H3-R2 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah] synonym: "histone H3 R2 methylation" EXACT [] synonym: "histone H3R2me" EXACT [] synonym: "histone lysine H3 R2 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034971 name: histone H3-R17 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah] synonym: "histone H3 R17 methylation" EXACT [] synonym: "histone H3R17me" EXACT [] synonym: "histone lysine H3 R17 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034972 name: histone H3-R26 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah] synonym: "histone H3 R26 methylation" EXACT [] synonym: "histone H3R26me" EXACT [] synonym: "histone lysine H3 R26 methylation" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0034973 name: Sid2-Mob1 complex namespace: cellular_component def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149] synonym: "Dbf2p-Mob1p complex" EXACT [] synonym: "Sid2-Mob1 kinase complex" EXACT [] synonym: "Sid2p-Mob1p complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034974 name: Swi5-Swi2 complex namespace: cellular_component def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140] comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p. synonym: "Swi5 complex" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0034975 name: protein folding in endoplasmic reticulum namespace: biological_process def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] synonym: "oxidative protein folding" EXACT [PMID:25091901] synonym: "protein folding in ER" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0034976 name: response to endoplasmic reticulum stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] synonym: "cellular response to endoplasmic reticulum stress" EXACT [] synonym: "ER stress response" EXACT [] synonym: "response to ER stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0034977 name: ABIN2-NFKB1-MAP3K8 complex namespace: cellular_component def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888] synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0034978 name: PDX1-PBX1b-MRG1 complex namespace: cellular_component def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595] synonym: "acinar cell-specific C complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034979 name: NAD-dependent protein deacetylase activity namespace: molecular_function def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah] xref: Reactome:R-HSA-3371467 "SIRT1 deacetylates HSF1" xref: Reactome:R-HSA-5211239 "SIRT1 deacetylates TAF1B in SL1 complex" xref: Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8" xref: Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2" xref: Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C" xref: Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3" is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0034980 name: FHL2-CREB complex namespace: cellular_component def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156] is_a: GO:0033202 ! DNA helicase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034981 name: FHL3-CREB complex namespace: cellular_component def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156] is_a: GO:0033202 ! DNA helicase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0034982 name: mitochondrial protein processing namespace: biological_process def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators] synonym: "mitochondrial protein modification" RELATED [] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process intersection_of: GO:0016485 ! protein processing intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0034983 name: peptidyl-lysine deacetylation namespace: biological_process def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah] synonym: "protein lysine acetylation" RELATED [] is_a: GO:0006476 ! protein deacetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0034985 name: Ecsit-NDUFAF1 complex namespace: cellular_component def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420] is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0034986 name: iron chaperone activity namespace: molecular_function def: "Directly binding to and delivering iron ions to a target protein." [GOC:BHF, GOC:vk] is_a: GO:0005506 ! iron ion binding is_a: GO:0016530 ! metallochaperone activity [Term] id: GO:0034987 name: immunoglobulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk] synonym: "Fc receptor binding" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0034988 name: Fc-gamma receptor I complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk] is_a: GO:0034987 ! immunoglobulin receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0034990 name: nuclear mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0000798 ! nuclear cohesin complex is_a: GO:0030892 ! mitotic cohesin complex [Term] id: GO:0034991 name: nuclear meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah] is_a: GO:0000798 ! nuclear cohesin complex is_a: GO:0030893 ! meiotic cohesin complex [Term] id: GO:0034992 name: microtubule organizing center attachment site namespace: cellular_component def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "MAS" EXACT [] synonym: "microtubule organising centre attachment site" EXACT [] synonym: "MTOC attachment site" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0034993 name: meiotic nuclear membrane microtubule tethering complex namespace: cellular_component def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis." [GOC:mah, PMID:18692466] synonym: "LINC complex" EXACT [] synonym: "LInker of Nucleoskeleton and Cytoskeleton complex" EXACT [] synonym: "SUN-KASH complex" EXACT [] is_a: GO:0106094 ! nuclear membrane microtubule tethering complex relationship: part_of GO:0034992 ! microtubule organizing center attachment site [Term] id: GO:0034994 name: microtubule organizing center attachment site organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466] synonym: "MAS organization" EXACT [] synonym: "microtubule organising centre attachment site organisation" RELATED [] synonym: "MTOC attachment site organization" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0006998 ! nuclear envelope organization [Term] id: GO:0034995 name: SC5b-7 complex namespace: cellular_component def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0034996 name: RasGAP-Fyn-Lyn-Yes complex namespace: cellular_component def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0034997 name: alphav-beta5 integrin-vitronectin complex namespace: cellular_component def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173] synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0034998 name: oligosaccharyltransferase I complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887] synonym: "OSTCI" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0034999 name: oligosaccharyltransferase II complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887] synonym: "OSTCII" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0035000 name: oligosaccharyltransferase III complex namespace: cellular_component def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887] synonym: "OSTCIII" EXACT [] is_a: GO:0008250 ! oligosaccharyltransferase complex [Term] id: GO:0035001 name: dorsal trunk growth, open tracheal system namespace: biological_process def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] synonym: "dorsal trunk growth" RELATED [] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035002 name: liquid clearance, open tracheal system namespace: biological_process def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] synonym: "tracheal liquid clearance" EXACT [] is_a: GO:0042045 ! epithelial fluid transport relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035003 name: subapical complex namespace: cellular_component def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] synonym: "SAC" BROAD [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0035004 name: phosphatidylinositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069, RHEA:12709] synonym: "phosphoinositide 3-kinase activity" EXACT [] xref: EC:2.7.1.137 xref: Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K" xref: Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3" xref: Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3" xref: RHEA:12709 xref: Wikipedia:Phosphoinositide_3-kinase is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation [Term] id: GO:0035005 name: 1-phosphatidylinositol-4-phosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18373] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154] synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "phosphatidylinositol-4-phosphate 3-kinase activity" EXACT [] synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154] xref: EC:2.7.1.154 xref: KEGG_REACTION:R05795 xref: MetaCyc:2.7.1.154-RXN xref: Reactome:R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane" xref: Reactome:R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane" xref: Reactome:R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane" xref: Reactome:R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2" xref: RHEA:18373 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0035006 name: melanization defense response namespace: biological_process def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] synonym: "melanization defence response" EXACT [] is_a: GO:0006582 ! melanin metabolic process is_a: GO:0044033 ! multi-organism metabolic process is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0045087 ! innate immune response [Term] id: GO:0035007 name: regulation of melanization defense response namespace: biological_process def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] synonym: "regulation of melanization defence response" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035006 ! melanization defense response relationship: regulates GO:0035006 ! melanization defense response [Term] id: GO:0035008 name: positive regulation of melanization defense response namespace: biological_process def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] synonym: "activation of melanization defense response" NARROW [] synonym: "positive regulation of melanization defence response" EXACT [] synonym: "stimulation of melanization defense response" NARROW [] synonym: "up regulation of melanization defense response" EXACT [] synonym: "up-regulation of melanization defense response" EXACT [] synonym: "upregulation of melanization defense response" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0035007 ! regulation of melanization defense response is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035006 ! melanization defense response relationship: positively_regulates GO:0035006 ! melanization defense response [Term] id: GO:0035009 name: negative regulation of melanization defense response namespace: biological_process def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] synonym: "down regulation of melanization defense response" EXACT [] synonym: "down-regulation of melanization defense response" EXACT [] synonym: "downregulation of melanization defense response" EXACT [] synonym: "inhibition of melanization defense response" NARROW [] synonym: "negative regulation of melanization defence response" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0035007 ! regulation of melanization defense response is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035006 ! melanization defense response relationship: negatively_regulates GO:0035006 ! melanization defense response [Term] id: GO:0035010 name: encapsulation of foreign target namespace: biological_process def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] comment: This term was improved by GO_REF:0000022. It was moved. is_a: GO:0002252 ! immune effector process [Term] id: GO:0035011 name: melanotic encapsulation of foreign target namespace: biological_process def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] is_a: GO:0035006 ! melanization defense response is_a: GO:0035010 ! encapsulation of foreign target [Term] id: GO:0035012 name: polytene chromosome, telomeric region namespace: cellular_component def: "The terminal region of a polytene chromosome." [GOC:bf] is_a: GO:0000781 ! chromosome, telomeric region intersection_of: GO:0000781 ! chromosome, telomeric region intersection_of: part_of GO:0005700 ! polytene chromosome relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0035013 name: myosuppressin receptor activity namespace: molecular_function def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0035014 name: phosphatidylinositol 3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. synonym: "phosphoinositide 3-kinase regulator activity" EXACT [] synonym: "PI3K regulator activity" EXACT [] is_a: GO:0019207 ! kinase regulator activity relationship: has_part GO:0036313 ! phosphatidylinositol 3-kinase catalytic subunit binding relationship: part_of GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity relationship: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0035015 name: elongation of arista core namespace: biological_process def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0035016 name: elongation of arista lateral namespace: biological_process def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0035017 name: cuticle pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] is_a: GO:0003002 ! regionalization relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0035018 name: adult chitin-based cuticle pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "adult cuticle pattern formation" BROAD [] is_a: GO:0035017 ! cuticle pattern formation relationship: part_of GO:0008365 ! adult chitin-based cuticle development [Term] id: GO:0035019 name: somatic stem cell population maintenance namespace: biological_process def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] is_a: GO:0019827 ! stem cell population maintenance [Term] id: GO:0035020 name: regulation of Rac protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016601 ! Rac protein signal transduction relationship: regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035021 name: negative regulation of Rac protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] synonym: "down regulation of Rac protein signal transduction" EXACT [] synonym: "down-regulation of Rac protein signal transduction" EXACT [] synonym: "downregulation of Rac protein signal transduction" EXACT [] synonym: "inhibition of Rac protein signal transduction" NARROW [] is_a: GO:0035020 ! regulation of Rac protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016601 ! Rac protein signal transduction relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035022 name: positive regulation of Rac protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] synonym: "activation of Rac protein signal transduction" NARROW [] synonym: "stimulation of Rac protein signal transduction" NARROW [] synonym: "up regulation of Rac protein signal transduction" EXACT [] synonym: "up-regulation of Rac protein signal transduction" EXACT [] synonym: "upregulation of Rac protein signal transduction" EXACT [] is_a: GO:0035020 ! regulation of Rac protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016601 ! Rac protein signal transduction relationship: positively_regulates GO:0016601 ! Rac protein signal transduction [Term] id: GO:0035023 name: regulation of Rho protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] is_a: GO:0046578 ! regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007266 ! Rho protein signal transduction relationship: regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035024 name: negative regulation of Rho protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] synonym: "down regulation of Rho protein signal transduction" EXACT [] synonym: "down-regulation of Rho protein signal transduction" EXACT [] synonym: "downregulation of Rho protein signal transduction" EXACT [] synonym: "inhibition of Rho protein signal transduction" NARROW [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007266 ! Rho protein signal transduction relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035025 name: positive regulation of Rho protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] synonym: "activation of Rho protein signal transduction" NARROW [] synonym: "stimulation of Rho protein signal transduction" NARROW [] synonym: "up regulation of Rho protein signal transduction" EXACT [] synonym: "up-regulation of Rho protein signal transduction" EXACT [] synonym: "upregulation of Rho protein signal transduction" EXACT [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007266 ! Rho protein signal transduction relationship: positively_regulates GO:0007266 ! Rho protein signal transduction [Term] id: GO:0035026 name: leading edge cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0035027 name: leading edge cell fate commitment namespace: biological_process def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0035026 ! leading edge cell differentiation [Term] id: GO:0035028 name: leading edge cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0035027 ! leading edge cell fate commitment [Term] id: GO:0035029 name: dorsal closure, leading edge cell fate commitment namespace: biological_process def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf] is_a: GO:0035027 ! leading edge cell fate commitment intersection_of: GO:0035027 ! leading edge cell fate commitment intersection_of: part_of GO:0007391 ! dorsal closure relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation [Term] id: GO:0035032 name: phosphatidylinositol 3-kinase complex, class III namespace: cellular_component def: "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069] synonym: "class III PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class III" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex [Term] id: GO:0035033 name: histone deacetylase regulator activity namespace: molecular_function def: "Modulates the activity of histone deacetylase." [GOC:bf] comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'. is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0042826 ! histone deacetylase binding relationship: part_of GO:0031063 ! regulation of histone deacetylation relationship: regulates GO:0004407 ! histone deacetylase activity [Term] id: GO:0035034 name: histone acetyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of histone acetyltransferase." [GOC:bf] comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0035035 ! histone acetyltransferase binding relationship: part_of GO:0035065 ! regulation of histone acetylation relationship: regulates GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0035035 name: histone acetyltransferase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme histone acetyltransferase." [GOC:bf] synonym: "histone acetylase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035036 name: sperm-egg recognition namespace: biological_process def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] is_a: GO:0009988 ! cell-cell recognition is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035037 name: sperm entry namespace: biological_process def: "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751] is_a: GO:0006897 ! endocytosis is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035038 name: female pronucleus assembly namespace: biological_process def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089] synonym: "female pronucleus assembly" RELATED [GOC:dph] is_a: GO:0006997 ! nucleus organization is_a: GO:0022414 ! reproductive process is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035039 name: male pronucleus assembly namespace: biological_process def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001] synonym: "male pronucleus formation" RELATED [GOC:dph] is_a: GO:0006997 ! nucleus organization is_a: GO:0022414 ! reproductive process is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035040 name: sperm nuclear envelope removal namespace: biological_process def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001] is_a: GO:0022414 ! reproductive process is_a: GO:0051081 ! nuclear envelope disassembly relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035041 name: sperm chromatin decondensation namespace: biological_process def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001] is_a: GO:0006325 ! chromatin organization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035042 name: fertilization, exchange of chromosomal proteins namespace: biological_process def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001] synonym: "sperm-specific histone exchange" EXACT [] synonym: "sperm-specific histone replacement" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0043486 ! histone exchange relationship: part_of GO:0035041 ! sperm chromatin decondensation [Term] id: GO:0035043 name: male pronuclear envelope synthesis namespace: biological_process def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001] is_a: GO:0018985 ! pronuclear envelope synthesis relationship: part_of GO:0035039 ! male pronucleus assembly [Term] id: GO:0035044 name: sperm aster formation namespace: biological_process def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035045 name: sperm plasma membrane disassembly namespace: biological_process def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] synonym: "sperm plasma membrane breakdown" EXACT [] synonym: "sperm plasma membrane catabolism" EXACT [] synonym: "sperm plasma membrane degradation" EXACT [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030397 ! membrane disassembly relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035046 name: pronuclear migration namespace: biological_process def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363] is_a: GO:0007097 ! nuclear migration is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035047 name: centrosomal and pronuclear rotation namespace: biological_process def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0035048 name: obsolete splicing factor protein import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT [] synonym: "splicing factor protein-nucleus import" EXACT [] is_obsolete: true consider: GO:0006606 [Term] id: GO:0035049 name: juvenile hormone acid methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007507 ! heart development relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0035051 name: cardiocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] synonym: "cardiac cell differentiation" EXACT [] synonym: "heart cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007507 ! heart development [Term] id: GO:0035052 name: dorsal vessel aortic cell fate commitment namespace: biological_process def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] is_a: GO:0060581 ! cell fate commitment involved in pattern specification is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification [Term] id: GO:0035053 name: dorsal vessel heart proper cell fate commitment namespace: biological_process def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] is_a: GO:0060581 ! cell fate commitment involved in pattern specification is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification [Term] id: GO:0035054 name: embryonic heart tube anterior/posterior pattern specification namespace: biological_process def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007507 ! heart development [Term] id: GO:0035059 name: RCAF complex namespace: cellular_component def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219] synonym: "replication-coupling assembly factor complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0035060 name: brahma complex namespace: cellular_component def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof." [GOC:bhm, PMID:10809665, PMID:12482982] synonym: "BRM complex" EXACT [] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0035061 name: interchromatin granule namespace: cellular_component def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] synonym: "ICG" EXACT [] xref: NIF_Subcellular:sao1049471211 is_a: GO:0016604 ! nuclear body [Term] id: GO:0035062 name: omega speckle namespace: cellular_component def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] is_a: GO:0016607 ! nuclear speck [Term] id: GO:0035063 name: nuclear speck organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators] comment: See also the cellular component term 'nuclear speck ; GO:0016607'. synonym: "nuclear speck organisation" EXACT [] synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear speckle assembly" NARROW [GOC:mah] synonym: "nuclear speckle organization" EXACT [] xref: MIPS_funcat:42.10.09 is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0035064 name: methylated histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf, PMID:14585615] is_a: GO:0042393 ! histone binding is_a: GO:0140034 ! methylation-dependent protein binding [Term] id: GO:0035065 name: regulation of histone acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] is_a: GO:0031056 ! regulation of histone modification is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016573 ! histone acetylation relationship: regulates GO:0016573 ! histone acetylation [Term] id: GO:0035066 name: positive regulation of histone acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] synonym: "activation of histone acetylation" NARROW [] synonym: "stimulation of histone acetylation" NARROW [] synonym: "up regulation of histone acetylation" EXACT [] synonym: "up-regulation of histone acetylation" EXACT [] synonym: "upregulation of histone acetylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0035065 ! regulation of histone acetylation is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016573 ! histone acetylation relationship: positively_regulates GO:0016573 ! histone acetylation [Term] id: GO:0035067 name: negative regulation of histone acetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] synonym: "down regulation of histone acetylation" EXACT [] synonym: "down-regulation of histone acetylation" EXACT [] synonym: "downregulation of histone acetylation" EXACT [] synonym: "inhibition of histone acetylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0035065 ! regulation of histone acetylation is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016573 ! histone acetylation relationship: negatively_regulates GO:0016573 ! histone acetylation [Term] id: GO:0035069 name: larval midgut histolysis namespace: biological_process def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683] synonym: "larval midgut regression" EXACT [] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0035070 name: salivary gland histolysis namespace: biological_process def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683] synonym: "salivary gland regression" EXACT [] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0035071 name: salivary gland cell autophagic cell death namespace: biological_process def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] synonym: "autophagic cell death of salivary gland cells" EXACT [] synonym: "programmed cell death of salivary gland cells by autophagy" EXACT [] synonym: "salivary gland cell death" EXACT [] synonym: "salivary gland cell programmed cell death by autophagy" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development is_a: GO:0048102 ! autophagic cell death relationship: part_of GO:0035070 ! salivary gland histolysis [Term] id: GO:0035072 name: ecdysone-mediated induction of salivary gland cell autophagic cell death namespace: biological_process def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT [] synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT [] synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT [] is_a: GO:0035078 ! induction of programmed cell death by ecdysone relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death [Term] id: GO:0035073 name: pupariation namespace: biological_process def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] synonym: "puparium biosynthesis" EXACT [] synonym: "puparium formation" EXACT [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0035210 ! prepupal development [Term] id: GO:0035074 name: pupation namespace: biological_process def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] synonym: "head eversion" EXACT [] synonym: "prepupal-pupal transition" EXACT [] xref: Wikipedia:Pupa is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0035075 name: response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] is_a: GO:0009725 ! response to hormone is_a: GO:0036314 ! response to sterol is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0035076 name: ecdysone receptor-mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] synonym: "ecdysone receptor-mediated signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway relationship: part_of GO:0071390 ! cellular response to ecdysone [Term] id: GO:0035077 name: ecdysone-mediated polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962] is_a: GO:0035079 ! polytene chromosome puffing relationship: part_of GO:0071390 ! cellular response to ecdysone [Term] id: GO:0035078 name: induction of programmed cell death by ecdysone namespace: biological_process def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf] is_a: GO:0035081 ! induction of programmed cell death by hormones relationship: part_of GO:0035075 ! response to ecdysone [Term] id: GO:0035079 name: polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0035080 name: heat shock-mediated polytene chromosome puffing namespace: biological_process def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] is_a: GO:0034605 ! cellular response to heat is_a: GO:0035079 ! polytene chromosome puffing [Term] id: GO:0035081 name: induction of programmed cell death by hormones namespace: biological_process def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf] is_a: GO:0012502 ! induction of programmed cell death [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process alt_id: GO:0035083 alt_id: GO:0035084 def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly [Term] id: GO:0035087 name: siRNA loading onto RISC involved in RNA interference namespace: biological_process def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] synonym: "RNA interference, siRNA loading onto RISC" EXACT [GOC:mah] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0035088 name: establishment or maintenance of apical/basal cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity [Term] id: GO:0035089 name: establishment of apical/basal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf] is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0035090 name: maintenance of apical/basal cell polarity namespace: biological_process def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf] is_a: GO:0030011 ! maintenance of cell polarity is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity [Term] id: GO:0035091 name: phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] synonym: "phosphoinositide binding" EXACT [] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0035092 name: sperm chromatin condensation namespace: biological_process def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001] is_a: GO:0006323 ! DNA packaging is_a: GO:0006325 ! chromatin organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0035093 name: spermatogenesis, exchange of chromosomal proteins namespace: biological_process def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001] synonym: "somatic histone exchange" EXACT [] synonym: "somatic histone replacement" RELATED [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0043486 ! histone exchange relationship: part_of GO:0035092 ! sperm chromatin condensation [Term] id: GO:0035094 name: response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] is_a: GO:0009636 ! response to toxic substance is_a: GO:0042493 ! response to drug [Term] id: GO:0035095 name: behavioral response to nicotine namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732] synonym: "behavioural response to nicotine" EXACT [] is_a: GO:0030534 ! adult behavior relationship: part_of GO:0035094 ! response to nicotine [Term] id: GO:0035096 name: larval midgut cell programmed cell death namespace: biological_process def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf, GOC:mtg_apoptosis] synonym: "larval midgut cell death" EXACT [] synonym: "programmed cell death of larval midgut cells" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: part_of GO:0035069 ! larval midgut histolysis [Term] id: GO:0035097 name: histone methyltransferase complex namespace: cellular_component def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf] subset: goslim_pir is_a: GO:0034708 ! methyltransferase complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0035098 name: ESC/E(Z) complex namespace: cellular_component def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT [] synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375] is_a: GO:0031519 ! PcG protein complex is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0035099 name: hemocyte migration namespace: biological_process def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] synonym: "arthropod blood cell migration" EXACT [] synonym: "hemocyte cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0035100 name: ecdysone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732, ISBN:0582227089] is_a: GO:0032934 ! sterol binding is_a: GO:0042562 ! hormone binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0035101 name: FACT complex namespace: cellular_component def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] synonym: "Facilitates chromatin transcription complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0035102 name: PRC1 complex namespace: cellular_component def: "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] comment: In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner. synonym: "Polycomb repressive complex 1" EXACT [] is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0031519 ! PcG protein complex [Term] id: GO:0035103 name: sterol regulatory element binding protein cleavage namespace: biological_process alt_id: GO:0006992 def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525] synonym: "SREBP cleavage" EXACT [] synonym: "sterol depletion response, SREBP cleavage" EXACT [] synonym: "sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway" NARROW [GOC:vw] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process relationship: part_of GO:0032933 ! SREBP signaling pathway [Term] id: GO:0035105 name: obsolete sterol regulatory element binding protein import into nucleus namespace: biological_process alt_id: GO:0006993 def: "OBSOLETE. The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, GOC:vw, PMID:12923525] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "SREBP import into nucleus" EXACT [GOC:mah] synonym: "SREBP import into nucleus involved in sterol depletion response" EXACT [GOC:mah] synonym: "SREBP nuclear translocation" NARROW [GOC:mah] synonym: "sterol depletion response, SREBP import into nucleus" EXACT [GOC:mah] synonym: "sterol depletion response, SREBP nuclear translocation" NARROW [GOC:mah] synonym: "sterol depletion response, sterol regulatory element binding protein import into nucleus" EXACT [] synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "sterol regulatory element binding protein import into nucleus involved in sterol depletion response" NARROW [GOC:vw] synonym: "sterol regulatory element binding protein nuclear translocation" NARROW [GOC:mah] synonym: "sterol regulatory element binding protein nuclear translocation involved in sterol depletion response" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 consider: GO:0042306 [Term] id: GO:0035106 name: operant conditioning namespace: biological_process def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] synonym: "instrumental conditioning" EXACT [] xref: Wikipedia:Operant_conditioning is_a: GO:0007612 ! learning [Term] id: GO:0035107 name: appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048736 ! appendage development [Term] id: GO:0035108 name: limb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101] synonym: "limb bud morphogenesis" NARROW [GOC:dph] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0060173 ! limb development [Term] id: GO:0035109 name: obsolete imaginal disc-derived limb morphogenesis namespace: biological_process def: "OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] comment: This term was made obsolete because the term 'limb' is not widely used in the insect community. In GO, 'limb' is used to describe the vertebrate hindlimbs and forelimbs. synonym: "imaginal disc-derived limb morphogenesis" EXACT [] is_obsolete: true consider: GO:0035114 [Term] id: GO:0035110 name: obsolete leg morphogenesis namespace: biological_process def: "OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001] comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. synonym: "leg morphogenesis" EXACT [] is_obsolete: true consider: GO:0007480 consider: GO:0035108 consider: GO:0035137 [Term] id: GO:0035111 name: obsolete leg joint morphogenesis namespace: biological_process def: "OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824] comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. synonym: "leg joint morphogenesis" EXACT [] is_obsolete: true consider: GO:0016348 consider: GO:0036023 [Term] id: GO:0035112 name: genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] synonym: "genital morphogenesis" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048806 ! genitalia development [Term] id: GO:0035113 name: embryonic appendage morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0035107 ! appendage morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0035114 name: imaginal disc-derived appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089] is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0048737 ! imaginal disc-derived appendage development [Term] id: GO:0035115 name: embryonic forelimb morphogenesis namespace: biological_process alt_id: GO:0035117 def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [ISBN:0198612001] synonym: "embryonic arm morphogenesis" NARROW [GOC:bf, GOC:cjm] is_a: GO:0030326 ! embryonic limb morphogenesis is_a: GO:0035136 ! forelimb morphogenesis [Term] id: GO:0035116 name: embryonic hindlimb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001] is_a: GO:0030326 ! embryonic limb morphogenesis is_a: GO:0035137 ! hindlimb morphogenesis [Term] id: GO:0035118 name: embryonic pectoral fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035113 ! embryonic appendage morphogenesis is_a: GO:0035138 ! pectoral fin morphogenesis [Term] id: GO:0035119 name: embryonic pelvic fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035113 ! embryonic appendage morphogenesis is_a: GO:0035139 ! pelvic fin morphogenesis [Term] id: GO:0035120 name: post-embryonic appendage morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0035107 ! appendage morphogenesis [Term] id: GO:0035121 name: obsolete tail morphogenesis namespace: biological_process def: "OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals." [ISBN:0198612001] comment: This term was made obsolete because 'tail' has different meanings in different organisms, and is therefore not a useful grouping term. synonym: "tail morphogenesis" EXACT [] is_obsolete: true consider: GO:0003002 consider: GO:0036342 consider: GO:0048809 [Term] id: GO:0035122 name: embryonic medial fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "embryonic unpaired fin morphogenesis" EXACT [] is_a: GO:0035113 ! embryonic appendage morphogenesis is_a: GO:0035141 ! medial fin morphogenesis [Term] id: GO:0035123 name: embryonic dorsal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035142 ! dorsal fin morphogenesis [Term] id: GO:0035124 name: embryonic caudal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035143 ! caudal fin morphogenesis [Term] id: GO:0035125 name: embryonic anal fin morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035122 ! embryonic medial fin morphogenesis is_a: GO:0035144 ! anal fin morphogenesis [Term] id: GO:0035126 name: post-embryonic genitalia morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] synonym: "post-embryonic genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0048563 ! post-embryonic animal organ morphogenesis [Term] id: GO:0035127 name: post-embryonic limb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis [Term] id: GO:0035128 name: post-embryonic forelimb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism." [GOC:bf] is_a: GO:0035127 ! post-embryonic limb morphogenesis is_a: GO:0035136 ! forelimb morphogenesis [Term] id: GO:0035129 name: post-embryonic hindlimb morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized." [GOC:bf] is_a: GO:0035127 ! post-embryonic limb morphogenesis is_a: GO:0035137 ! hindlimb morphogenesis [Term] id: GO:0035130 name: post-embryonic pectoral fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035120 ! post-embryonic appendage morphogenesis is_a: GO:0035138 ! pectoral fin morphogenesis [Term] id: GO:0035131 name: post-embryonic pelvic fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0035120 ! post-embryonic appendage morphogenesis is_a: GO:0035139 ! pelvic fin morphogenesis [Term] id: GO:0035132 name: post-embryonic medial fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "post-embryonic unpaired fin morphogenesis" EXACT [] is_a: GO:0035120 ! post-embryonic appendage morphogenesis is_a: GO:0035141 ! medial fin morphogenesis [Term] id: GO:0035133 name: post-embryonic caudal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035143 ! caudal fin morphogenesis [Term] id: GO:0035134 name: post-embryonic dorsal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035142 ! dorsal fin morphogenesis [Term] id: GO:0035135 name: post-embryonic anal fin morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035132 ! post-embryonic medial fin morphogenesis is_a: GO:0035144 ! anal fin morphogenesis [Term] id: GO:0035136 name: forelimb morphogenesis namespace: biological_process alt_id: GO:0035140 def: "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [GOC:go_curators] synonym: "arm morphogenesis" NARROW [GOC:bf, GOC:cjm] is_a: GO:0035108 ! limb morphogenesis [Term] id: GO:0035137 name: hindlimb morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators] is_a: GO:0035108 ! limb morphogenesis [Term] id: GO:0035138 name: pectoral fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0033334 ! fin morphogenesis relationship: part_of GO:0033339 ! pectoral fin development [Term] id: GO:0035139 name: pelvic fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] is_a: GO:0033334 ! fin morphogenesis relationship: part_of GO:0033340 ! pelvic fin development [Term] id: GO:0035141 name: medial fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] synonym: "unpaired fin morphogenesis" EXACT [] is_a: GO:0033334 ! fin morphogenesis relationship: part_of GO:0033338 ! medial fin development [Term] id: GO:0035142 name: dorsal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033337 ! dorsal fin development [Term] id: GO:0035143 name: caudal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033336 ! caudal fin development [Term] id: GO:0035144 name: anal fin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] is_a: GO:0035141 ! medial fin morphogenesis relationship: part_of GO:0033335 ! anal fin development [Term] id: GO:0035145 name: exon-exon junction complex namespace: cellular_component def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] synonym: "EJC" EXACT [] synonym: "exon junction complex" EXACT [GOC:dph] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0035146 name: tube fusion namespace: biological_process def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0048754 ! branching morphogenesis of an epithelial tube [Term] id: GO:0035147 name: branch fusion, open tracheal system namespace: biological_process def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] synonym: "tracheal branch fusion" EXACT [] is_a: GO:0035146 ! tube fusion relationship: part_of GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035239 ! tube morphogenesis [Term] id: GO:0035149 name: lumen formation, open tracheal system namespace: biological_process def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal lumen formation" EXACT [] is_a: GO:0035148 ! tube formation is_a: GO:0035152 ! regulation of tube architecture, open tracheal system [Term] id: GO:0035150 name: regulation of tube size namespace: biological_process def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083] is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0035151 name: regulation of tube size, open tracheal system namespace: biological_process def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] synonym: "regulation of tracheal tube size" EXACT [] is_a: GO:0035150 ! regulation of tube size is_a: GO:0035152 ! regulation of tube architecture, open tracheal system intersection_of: GO:0035150 ! regulation of tube size intersection_of: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035152 name: regulation of tube architecture, open tracheal system namespace: biological_process def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] synonym: "regulation of tracheal tube architecture" EXACT [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035153 name: epithelial cell type specification, open tracheal system namespace: biological_process def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] synonym: "tracheal cell type specification" BROAD [] synonym: "tracheal epithelial cell type specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035154 name: terminal cell fate specification, open tracheal system namespace: biological_process def: "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] synonym: "terminal cell fate specification" EXACT [] is_a: GO:0035153 ! epithelial cell type specification, open tracheal system [Term] id: GO:0035155 name: negative regulation of terminal cell fate specification, open tracheal system namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581] synonym: "down regulation of terminal cell fate specification" EXACT [] synonym: "down-regulation of terminal cell fate specification" EXACT [] synonym: "downregulation of terminal cell fate specification" EXACT [] synonym: "inhibition of terminal cell fate specification" NARROW [] synonym: "negative regulation of terminal cell fate specification" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system [Term] id: GO:0035156 name: fusion cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940] is_a: GO:0035153 ! epithelial cell type specification, open tracheal system [Term] id: GO:0035157 name: negative regulation of fusion cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581] synonym: "down regulation of fusion cell fate specification" EXACT [] synonym: "down-regulation of fusion cell fate specification" EXACT [] synonym: "downregulation of fusion cell fate specification" EXACT [] synonym: "inhibition of fusion cell fate specification" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035156 ! fusion cell fate specification relationship: negatively_regulates GO:0035156 ! fusion cell fate specification [Term] id: GO:0035158 name: regulation of tube diameter, open tracheal system namespace: biological_process def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] synonym: "regulation of tracheal tube diameter" EXACT [] synonym: "tracheal tube dilation" NARROW [] synonym: "tracheal tube expansion" NARROW [] is_a: GO:0035159 ! regulation of tube length, open tracheal system is_a: GO:0035296 ! regulation of tube diameter [Term] id: GO:0035159 name: regulation of tube length, open tracheal system namespace: biological_process def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] synonym: "regulation of tracheal tube length" EXACT [] synonym: "tracheal tube elongation" NARROW [] is_a: GO:0035151 ! regulation of tube size, open tracheal system [Term] id: GO:0035160 name: maintenance of epithelial integrity, open tracheal system namespace: biological_process def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] synonym: "maintenance of tracheal epithelial integrity" EXACT [] is_a: GO:0010669 ! epithelial structure maintenance is_a: GO:0035152 ! regulation of tube architecture, open tracheal system [Term] id: GO:0035161 name: imaginal disc lineage restriction namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0007447 ! imaginal disc pattern formation [Term] id: GO:0035162 name: embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place within the embryo." [GOC:bf] synonym: "embryonic haematopoiesis" EXACT [] synonym: "embryonic haemopoiesis" EXACT [] synonym: "embryonic hematopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0035163 name: embryonic hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "embryonic arthropod blood cell differentiation" EXACT [] synonym: "embryonic hemocyte cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation relationship: part_of GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0035164 name: embryonic plasmatocyte differentiation namespace: biological_process def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] synonym: "embryonic plasmatocyte cell differentiation" EXACT [] is_a: GO:0035163 ! embryonic hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0035165 name: embryonic crystal cell differentiation namespace: biological_process def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035163 ! embryonic hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation [Term] id: GO:0035166 name: post-embryonic hemopoiesis namespace: biological_process def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf] synonym: "post-embryonic haemopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0035167 name: larval lymph gland hemopoiesis namespace: biological_process def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] synonym: "larval lymph gland haematopoiesis" EXACT [] synonym: "larval lymph gland haemopoiesis" EXACT [] synonym: "larval lymph gland hematopoiesis" EXACT [] is_a: GO:0035166 ! post-embryonic hemopoiesis relationship: part_of GO:0002164 ! larval development relationship: part_of GO:0048542 ! lymph gland development [Term] id: GO:0035168 name: larval lymph gland hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069] synonym: "larval lymph gland arthropod blood cell differentiation" EXACT [] is_a: GO:0042386 ! hemocyte differentiation relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis [Term] id: GO:0035169 name: lymph gland plasmatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] synonym: "lymph gland plasmatocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0035170 name: lymph gland crystal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042688 ! crystal cell differentiation [Term] id: GO:0035171 name: lamellocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] synonym: "lamellocyte cell differentiation" EXACT [] is_a: GO:0035168 ! larval lymph gland hemocyte differentiation is_a: GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0035172 name: hemocyte proliferation namespace: biological_process def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell proliferation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0035173 name: histone kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] is_a: GO:0004672 ! protein kinase activity relationship: part_of GO:0016572 ! histone phosphorylation [Term] id: GO:0035174 name: histone serine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] synonym: "histone-serine kinase activity" EXACT [] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0035173 ! histone kinase activity relationship: part_of GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0035175 name: histone kinase activity (H3-S10 specific) namespace: molecular_function alt_id: GO:0044021 def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] synonym: "histone kinase activity (H3-S3 specific)" EXACT [] synonym: "histone serine kinase activity (H3-S10 specific)" EXACT [] synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0043987 ! histone H3-S10 phosphorylation [Term] id: GO:0035176 name: social behavior namespace: biological_process def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. synonym: "cooperative behavior" RELATED [] synonym: "social behaviour" EXACT [] xref: Wikipedia:Social_behavior is_a: GO:0051703 ! intraspecies interaction between organisms is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0035177 name: larval foraging behavior namespace: biological_process def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] synonym: "larval foraging behaviour" EXACT [] is_a: GO:0030537 ! larval behavior is_a: GO:0060756 ! foraging behavior [Term] id: GO:0035178 name: turning behavior namespace: biological_process def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478] synonym: "turning behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior [Term] id: GO:0035179 name: larval turning behavior namespace: biological_process def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478] synonym: "larval turning behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior is_a: GO:0035178 ! turning behavior [Term] id: GO:0035180 name: larval wandering behavior namespace: biological_process def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] synonym: "larval wandering behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0035181 name: larval burrowing behavior namespace: biological_process def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939] synonym: "larval burrowing behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0035182 name: female germline ring canal outer rim namespace: cellular_component def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006] comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. synonym: "germline ring canal outer rim" BROAD [] synonym: "nurse cell ring canal outer rim" NARROW [] synonym: "ovarian ring canal outer rim" NARROW [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0035324 ! female germline ring canal [Term] id: GO:0035183 name: female germline ring canal inner rim namespace: cellular_component def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. synonym: "germline ring canal inner rim" BROAD [] synonym: "nurse cell ring canal inner rim" NARROW [] synonym: "ovarian ring canal inner rim" NARROW [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0035324 ! female germline ring canal [Term] id: GO:0035184 name: histone threonine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] synonym: "histone-threonine kinase activity" EXACT [] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0035173 ! histone kinase activity relationship: part_of GO:0035405 ! histone-threonine phosphorylation [Term] id: GO:0035185 name: preblastoderm mitotic cell cycle namespace: biological_process def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238] is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis is_a: GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0035186 name: syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis is_a: GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0035187 name: hatching behavior namespace: biological_process def: "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] synonym: "hatching behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0035188 ! hatching [Term] id: GO:0035188 name: hatching namespace: biological_process def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001] is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035189 name: Rb-E2F complex namespace: cellular_component def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] synonym: "retinoblastoma-E2F complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0035190 name: syncytial nuclear migration namespace: biological_process def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0035191 name: nuclear axial expansion namespace: biological_process def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] synonym: "nuclear distribution along anterior-posterior axis" EXACT [] synonym: "nucleus distribution along anterior-posterior axis" EXACT [] is_a: GO:0035190 ! syncytial nuclear migration [Term] id: GO:0035192 name: nuclear cortical migration namespace: biological_process def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839] is_a: GO:0035190 ! syncytial nuclear migration [Term] id: GO:0035193 name: larval central nervous system remodeling namespace: biological_process def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692] synonym: "central nervous system metamorphosis" EXACT [] synonym: "CNS metamorphosis" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002165 ! instar larval or pupal development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0035194 name: posttranscriptional gene silencing by RNA namespace: biological_process def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation." [GOC:aruk, GOC:bc, GOC:mah, GOC:rl, PMID:15020054, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604] synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] synonym: "sense-PTGS" RELATED [] is_a: GO:0016441 ! posttranscriptional gene silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0035195 name: gene silencing by miRNA namespace: biological_process def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604] synonym: "gene silencing by microRNA" EXACT [GOC:pr] synonym: "microRNA-mediated gene silencing" EXACT [] synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0035194 ! posttranscriptional gene silencing by RNA [Term] id: GO:0035196 name: production of miRNAs involved in gene silencing by miRNA namespace: biological_process alt_id: GO:0030918 def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604] synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah] synonym: "microRNA biogenesis" RELATED [GOC:tb] synonym: "microRNA biosynthesis" RELATED [] synonym: "microRNA biosynthetic process" RELATED [] synonym: "microRNA metabolic process" RELATED [] synonym: "microRNA metabolism" RELATED [] synonym: "microRNA processing" BROAD [] synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT [] synonym: "miRNA biogenesis" RELATED [GOC:tb] synonym: "miRNA processing" EXACT [] synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb] synonym: "production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:pr] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035197 name: siRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] synonym: "small interfering RNA binding" EXACT [] is_a: GO:0061980 ! regulatory RNA binding [Term] id: GO:0035198 name: miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] synonym: "microRNA binding" EXACT [] is_a: GO:0061980 ! regulatory RNA binding [Term] id: GO:0035199 name: salt aversion namespace: biological_process def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] synonym: "behavioral response to salt" BROAD [] is_a: GO:0007631 ! feeding behavior relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0035200 name: leg disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf] is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0035201 name: leg disc anterior/posterior lineage restriction namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf] is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation [Term] id: GO:0035202 name: tracheal pit formation in open tracheal system namespace: biological_process def: "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584] synonym: "tracheal placode invagination" RELATED [] synonym: "tracheal sac formation" BROAD [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035203 name: regulation of lamellocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] is_a: GO:0045613 ! regulation of plasmatocyte differentiation is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035171 ! lamellocyte differentiation relationship: regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035204 name: negative regulation of lamellocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "down regulation of lamellocyte differentiation" EXACT [] synonym: "down-regulation of lamellocyte differentiation" EXACT [] synonym: "downregulation of lamellocyte differentiation" EXACT [] synonym: "inhibition of lamellocyte differentiation" NARROW [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045614 ! negative regulation of plasmatocyte differentiation is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035171 ! lamellocyte differentiation relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035205 name: positive regulation of lamellocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] synonym: "activation of lamellocyte differentiation" NARROW [] synonym: "stimulation of lamellocyte differentiation" NARROW [] synonym: "up regulation of lamellocyte differentiation" EXACT [] synonym: "up-regulation of lamellocyte differentiation" EXACT [] synonym: "upregulation of lamellocyte differentiation" EXACT [] is_a: GO:0035203 ! regulation of lamellocyte differentiation is_a: GO:0045615 ! positive regulation of plasmatocyte differentiation is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035171 ! lamellocyte differentiation relationship: positively_regulates GO:0035171 ! lamellocyte differentiation [Term] id: GO:0035206 name: regulation of hemocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035172 ! hemocyte proliferation relationship: regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035207 name: negative regulation of hemocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "down regulation of hemocyte proliferation" EXACT [] synonym: "down-regulation of hemocyte proliferation" EXACT [] synonym: "downregulation of hemocyte proliferation" EXACT [] synonym: "inhibition of hemocyte proliferation" NARROW [] synonym: "negative regulation of arthropod blood cell proliferation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035172 ! hemocyte proliferation relationship: negatively_regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035208 name: positive regulation of hemocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "activation of hemocyte proliferation" NARROW [] synonym: "positive regulation of arthropod blood cell proliferation" EXACT [] synonym: "stimulation of hemocyte proliferation" NARROW [] synonym: "up regulation of hemocyte proliferation" EXACT [] synonym: "up-regulation of hemocyte proliferation" EXACT [] synonym: "upregulation of hemocyte proliferation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0035206 ! regulation of hemocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035172 ! hemocyte proliferation relationship: positively_regulates GO:0035172 ! hemocyte proliferation [Term] id: GO:0035209 name: pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0035210 name: prepupal development namespace: biological_process def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm] comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'. is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0035211 name: spermathecum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'. is_a: GO:0009887 ! animal organ morphogenesis [Term] id: GO:0035212 name: cell competition in a multicellular organism namespace: biological_process def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] is_a: GO:0009987 ! cellular process is_a: GO:0040008 ! regulation of growth relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035213 name: clypeo-labral disc development namespace: biological_process def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238] synonym: "development of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035214 name: eye-antennal disc development namespace: biological_process def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035215 name: genital disc development namespace: biological_process def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035216 name: haltere disc development namespace: biological_process def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035217 name: labial disc development namespace: biological_process def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035218 name: leg disc development namespace: biological_process def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035219 name: prothoracic disc development namespace: biological_process def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035220 name: wing disc development namespace: biological_process def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] is_a: GO:0007444 ! imaginal disc development [Term] id: GO:0035221 name: genital disc pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035222 name: wing disc pattern formation namespace: biological_process def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0035223 name: leg disc pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf] is_a: GO:0007447 ! imaginal disc pattern formation relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0035224 name: genital disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc is_a: GO:0035221 ! genital disc pattern formation [Term] id: GO:0035225 name: determination of genital disc primordium namespace: biological_process def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] is_a: GO:0007445 ! determination of imaginal disc primordium relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035226 name: glutamate-cysteine ligase catalytic subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0035227 name: regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf] is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004357 ! glutamate-cysteine ligase activity relationship: regulates GO:0004357 ! glutamate-cysteine ligase activity [Term] id: GO:0035228 name: negative regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf] synonym: "down regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "downregulation of glutamate-cysteine ligase activity" EXACT [] synonym: "inhibition of glutamate-cysteine ligase activity" NARROW [] is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity is_a: GO:0051352 ! negative regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004357 ! glutamate-cysteine ligase activity relationship: negatively_regulates GO:0004357 ! glutamate-cysteine ligase activity [Term] id: GO:0035229 name: positive regulation of glutamate-cysteine ligase activity namespace: biological_process def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617] synonym: "activation of glutamate-cysteine ligase activity" NARROW [] synonym: "stimulation of glutamate-cysteine ligase activity" NARROW [] synonym: "up regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT [] synonym: "upregulation of glutamate-cysteine ligase activity" EXACT [] is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity is_a: GO:0051351 ! positive regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004357 ! glutamate-cysteine ligase activity relationship: positively_regulates GO:0004357 ! glutamate-cysteine ligase activity [Term] id: GO:0035230 name: cytoneme namespace: cellular_component def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901] subset: goslim_pir synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube] xref: Wikipedia:Membrane_nanotube is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0035231 name: cytoneme assembly namespace: biological_process def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901] synonym: "cytoneme biogenesis" RELATED [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0003399 ! cytoneme morphogenesis [Term] id: GO:0035232 name: germ cell attraction namespace: biological_process def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0050918 ! positive chemotaxis is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0008354 ! germ cell migration [Term] id: GO:0035233 name: germ cell repulsion namespace: biological_process def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0050919 ! negative chemotaxis is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0008354 ! germ cell migration [Term] id: GO:0035234 name: ectopic germ cell programmed cell death namespace: biological_process def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] synonym: "programmed cell death of ectopic germ cells" EXACT [] synonym: "programmed cell death, ectopic germ cells" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development [Term] id: GO:0035235 name: ionotropic glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] synonym: "ionotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007215 ! glutamate receptor signaling pathway [Term] id: GO:0035236 name: proctolin receptor activity namespace: molecular_function def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0035237 name: corazonin receptor activity namespace: molecular_function def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0035238 name: vitamin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606] synonym: "vitamin A anabolism" EXACT [] synonym: "vitamin A biosynthesis" EXACT [] synonym: "vitamin A formation" EXACT [] synonym: "vitamin A synthesis" EXACT [] is_a: GO:0006776 ! vitamin A metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035295 ! tube development [Term] id: GO:0035240 name: dopamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0070405 ! ammonium ion binding is_a: GO:1901338 ! catecholamine binding [Term] id: GO:0035241 name: protein-arginine omega-N monomethyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069] comment: Type III protein arginine methyltransferases catalyze the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyze this reaction, type III enzymes do not methylate the substrate any further. synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)" RELATED [EC:2.1.1.321] synonym: "type III protein arginine methyltransferase activity" RELATED [EC:2.1.1.321] xref: EC:2.1.1.321 xref: RESID:AA0069 xref: RHEA:48100 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity relationship: part_of GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0035242 name: protein-arginine omega-N asymmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [EC:2.1.1.319, PMID:14705965, RESID:AA0068, RESID:AA0069] comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.319] synonym: "type I PRMT activity" RELATED [] synonym: "type I protein arginine methyltransferase activity" RELATED [] {comment="EC:2.1.1.319"} xref: EC:2.1.1.319 xref: RESID:AA0068 xref: RESID:AA0069 xref: RHEA:48096 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity relationship: part_of GO:0019919 ! peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [Term] id: GO:0035243 name: protein-arginine omega-N symmetric methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069] comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.320] synonym: "type II PRMT activity" RELATED [] synonym: "type II protein arginine methyltransferase activity" RELATED [] xref: EC:2.1.1.320 xref: Reactome:R-HSA-6804383 "PRMT5 methylates TP53" xref: RESID:AA0067 xref: RESID:AA0069 xref: RHEA:48108 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity relationship: part_of GO:0019918 ! peptidyl-arginine methylation, to symmetrical-dimethyl arginine [Term] id: GO:0035244 name: peptidyl-arginine C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity relationship: part_of GO:0035245 ! peptidyl-arginine C-methylation [Term] id: GO:0035245 name: peptidyl-arginine C-methylation namespace: biological_process def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf] is_a: GO:0018216 ! peptidyl-arginine methylation [Term] id: GO:0035246 name: peptidyl-arginine N-methylation namespace: biological_process def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf] is_a: GO:0018216 ! peptidyl-arginine methylation [Term] id: GO:0035247 name: peptidyl-arginine omega-N-methylation namespace: biological_process def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069] xref: RESID:AA0067 xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0035248 name: alpha-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] synonym: "alpha-1,4-GalNAc transferase activity" EXACT [] is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0035249 name: synaptic transmission, glutamatergic namespace: biological_process def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0035250 name: UDP-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0035251 name: UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1912353 "Glucosylation of Pre-NOTCH by POGLUT1" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0035252 name: UDP-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] xref: Reactome:R-HSA-5617138 "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA" xref: Reactome:R-HSA-6785668 "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA" xref: Reactome:R-HSA-9638090 "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0035253 name: ciliary rootlet namespace: cellular_component def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867] synonym: "cilial rootlet" EXACT [] synonym: "cilium rootlet" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0005929 ! cilium [Term] id: GO:0035254 name: glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glutamate receptor." [GOC:bf] subset: goslim_chembl is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0035255 name: ionotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732] is_a: GO:0035254 ! glutamate receptor binding [Term] id: GO:0035256 name: G protein-coupled glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)." [GOC:bf, ISBN:0198506732, PMID:9069287] synonym: "G-protein coupled glutamate receptor binding" EXACT [] synonym: "metabotropic glutamate receptor binding" EXACT [GOC:bf] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0035254 ! glutamate receptor binding [Term] id: GO:0035257 name: nuclear hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] is_a: GO:0051427 ! hormone receptor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0035258 name: steroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0035259 name: glucocorticoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glucocorticoid receptor." [GOC:bf] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0035260 name: internal genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html] is_a: GO:0035112 ! genitalia morphogenesis [Term] id: GO:0035261 name: external genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html] is_a: GO:0035112 ! genitalia morphogenesis [Term] id: GO:0035262 name: gonad morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0035263 name: genital disc sexually dimorphic development namespace: biological_process def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007548 ! sex differentiation relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth [Term] id: GO:0035266 name: meristem growth namespace: biological_process def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0035267 name: NuA4 histone acetyltransferase complex namespace: cellular_component def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] synonym: "TIP60 histone acetylase complex" EXACT [] synonym: "TIP60 histone acetyltransferase complex" EXACT [] is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex [Term] id: GO:0035268 name: protein mannosylation namespace: biological_process def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf, GOC:pr] synonym: "protein amino acid mannosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation is_a: GO:0097502 ! mannosylation [Term] id: GO:0035269 name: protein O-linked mannosylation namespace: biological_process def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797] synonym: "protein amino acid O-linked mannosylation" EXACT [GOC:bf] is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0035268 ! protein mannosylation [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, http://encyclopedia.thefreedictionary.com/Endocrine+sytem, ISBN:0198506732] is_a: GO:0048731 ! system development [Term] id: GO:0035271 name: ring gland development namespace: biological_process def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098] comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799. is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0035272 name: exocrine system development namespace: biological_process def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, http://encyclopedia.thefreedictionary.com/Exocrine+gland, ISBN:0198506732] is_a: GO:0048731 ! system development [Term] id: GO:0035273 name: phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html] subset: goslim_pir is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0035274 name: diphenyl phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] synonym: "DPP binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0035275 name: dibutyl phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] synonym: "DBP binding" EXACT [] synonym: "phthalic acid dibutyl ester binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0035276 name: ethanol binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0035277 name: spiracle morphogenesis, open tracheal system namespace: biological_process def: "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] synonym: "spiracle morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0035278 name: miRNA mediated inhibition of translation namespace: biological_process def: "The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs" [PMID:14744438, PMID:15196554] synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah] synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah] synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:pr] is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035279 name: mRNA cleavage involved in gene silencing by miRNA namespace: biological_process def: "The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554] synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah] synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb] synonym: "mRNA cleavage involved in gene silencing by microRNA" EXACT [GOC:pr] is_a: GO:0098795 ! mRNA cleavage involved in gene silencing intersection_of: GO:0006379 ! mRNA cleavage intersection_of: part_of GO:0035195 ! gene silencing by miRNA relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035280 name: miRNA loading onto RISC involved in gene silencing by miRNA namespace: biological_process def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438] synonym: "gene silencing by miRNA, miRNA loading onto RISC" EXACT [GOC:mah] synonym: "microRNA loading onto RISC involved in gene silencing by microRNA" EXACT [GOC:pr] synonym: "miRISC assembly" BROAD [] synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035281 name: pre-miRNA export from nucleus namespace: biological_process def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [GOC:sl, PMID:14744438] synonym: "pre-microRNA export from cell nucleus" EXACT [] synonym: "pre-microRNA export from nucleus" RELATED [] synonym: "pre-microRNA export out of nucleus" EXACT [] synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT [] synonym: "pre-microRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization [Term] id: GO:0035283 name: central nervous system segmentation namespace: biological_process def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0035284 name: brain segmentation namespace: biological_process def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0035283 ! central nervous system segmentation [Term] id: GO:0035285 name: appendage segmentation namespace: biological_process def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895] is_a: GO:0035282 ! segmentation relationship: part_of GO:0035107 ! appendage morphogenesis [Term] id: GO:0035286 name: obsolete leg segmentation namespace: biological_process def: "OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895] comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. synonym: "leg segmentation" EXACT [] is_obsolete: true consider: GO:0035285 consider: GO:0036011 [Term] id: GO:0035287 name: head segmentation namespace: biological_process def: "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837] comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children. is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0007350 ! blastoderm segmentation relationship: part_of GO:0060322 ! head development [Term] id: GO:0035288 name: anterior head segmentation namespace: biological_process def: "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children. synonym: "procephalic segmentation" RELATED [] is_a: GO:0035287 ! head segmentation relationship: part_of GO:0097065 ! anterior head development [Term] id: GO:0035289 name: posterior head segmentation namespace: biological_process def: "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children. synonym: "gnathal segmentation" RELATED [] is_a: GO:0035287 ! head segmentation [Term] id: GO:0035290 name: trunk segmentation namespace: biological_process def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] is_a: GO:0035282 ! segmentation relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0035291 name: specification of segmental identity, intercalary segment namespace: biological_process def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305] comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0035292 name: specification of segmental identity, trunk namespace: biological_process def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035290 ! trunk segmentation [Term] id: GO:0035293 name: chitin-based larval cuticle pattern formation namespace: biological_process def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035017 ! cuticle pattern formation relationship: part_of GO:0008363 ! larval chitin-based cuticle development [Term] id: GO:0035294 name: determination of wing disc primordium namespace: biological_process def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238] is_a: GO:0007445 ! determination of imaginal disc primordium is_a: GO:0035220 ! wing disc development [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0035296 name: regulation of tube diameter namespace: biological_process def: "Any process that modulates the diameter of a tube." [GOC:bf] is_a: GO:0035150 ! regulation of tube size [Term] id: GO:0035297 name: regulation of Malpighian tubule diameter namespace: biological_process def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] is_a: GO:0035296 ! regulation of tube diameter is_a: GO:0035298 ! regulation of Malpighian tubule size [Term] id: GO:0035298 name: regulation of Malpighian tubule size namespace: biological_process def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf] is_a: GO:0035150 ! regulation of tube size relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis [Term] id: GO:0035299 name: inositol pentakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [EC:2.7.1.158, RHEA:20313] synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158] synonym: "Gsl1p" RELATED [EC:2.7.1.158] synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158] synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158] synonym: "Ipk1p" RELATED [EC:2.7.1.158] xref: EC:2.7.1.158 xref: KEGG_REACTION:R05202 xref: MetaCyc:RXN-7163 xref: Reactome:R-HSA-1855176 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus" xref: Reactome:R-HSA-1855179 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol" xref: RHEA:20313 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0035300 name: obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159] synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW [] synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW [] synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "inositol-1,3,4-trisphosphate 5/6-kinase activity" EXACT [] synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159] synonym: "IP56K" RELATED [EC:2.7.1.159] is_obsolete: true consider: GO:0052725 consider: GO:0052726 [Term] id: GO:0035301 name: Hedgehog signaling complex namespace: cellular_component def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936] synonym: "Hedgehog signalling complex" EXACT [] synonym: "HSC" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0035302 name: ecdysteroid 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732, PMID:15350618] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0035303 name: regulation of dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016311 ! dephosphorylation relationship: regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035304 name: regulation of protein dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] synonym: "regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0035303 ! regulation of dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006470 ! protein dephosphorylation relationship: regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035305 name: negative regulation of dephosphorylation namespace: biological_process def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] synonym: "down regulation of dephosphorylation" EXACT [] synonym: "down-regulation of dephosphorylation" EXACT [] synonym: "downregulation of dephosphorylation" EXACT [] synonym: "inhibition of dephosphorylation" NARROW [] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016311 ! dephosphorylation relationship: negatively_regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035306 name: positive regulation of dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] synonym: "activation of dephosphorylation" NARROW [] synonym: "stimulation of dephosphorylation" NARROW [] synonym: "up regulation of dephosphorylation" EXACT [] synonym: "up-regulation of dephosphorylation" EXACT [] synonym: "upregulation of dephosphorylation" EXACT [] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016311 ! dephosphorylation relationship: positively_regulates GO:0016311 ! dephosphorylation [Term] id: GO:0035307 name: positive regulation of protein dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] synonym: "activation of protein amino acid dephosphorylation" NARROW [] synonym: "positive regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid dephosphorylation" NARROW [] synonym: "up regulation of protein amino acid dephosphorylation" EXACT [] synonym: "up-regulation of protein amino acid dephosphorylation" EXACT [] synonym: "upregulation of protein amino acid dephosphorylation" EXACT [] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0035304 ! regulation of protein dephosphorylation is_a: GO:0035306 ! positive regulation of dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006470 ! protein dephosphorylation relationship: positively_regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035308 name: negative regulation of protein dephosphorylation namespace: biological_process def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] synonym: "down regulation of protein amino acid dephosphorylation" EXACT [] synonym: "down-regulation of protein amino acid dephosphorylation" EXACT [] synonym: "downregulation of protein amino acid dephosphorylation" EXACT [] synonym: "inhibition of protein amino acid dephosphorylation" NARROW [] synonym: "negative regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0035304 ! regulation of protein dephosphorylation is_a: GO:0035305 ! negative regulation of dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006470 ! protein dephosphorylation relationship: negatively_regulates GO:0006470 ! protein dephosphorylation [Term] id: GO:0035309 name: wing and notum subfield formation namespace: biological_process def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] is_a: GO:0003002 ! regionalization relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0035310 name: notum cell fate specification namespace: biological_process def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0035309 ! wing and notum subfield formation [Term] id: GO:0035311 name: wing cell fate specification namespace: biological_process def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0035309 ! wing and notum subfield formation [Term] id: GO:0035312 name: 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0035313 name: wound healing, spreading of epidermal cells namespace: biological_process def: "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis." [GOC:bf, PMID:15269788] is_a: GO:0044319 ! wound healing, spreading of cells [Term] id: GO:0035314 name: scab formation namespace: biological_process def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0035315 name: hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf] is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0035316 name: non-sensory hair organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah] synonym: "trichome organisation" BROAD [] synonym: "trichome organization and biogenesis" BROAD [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization relationship: part_of GO:0035315 ! hair cell differentiation [Term] id: GO:0035317 name: imaginal disc-derived wing hair organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'. synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah] synonym: "wing hair organisation" EXACT [] synonym: "wing hair organization and biogenesis" RELATED [GOC:mah] synonym: "wing trichome organization and biogenesis" EXACT [] is_a: GO:0035316 ! non-sensory hair organization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0035318 name: imaginal disc-derived wing hair outgrowth namespace: biological_process def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] synonym: "wing hair outgrowth" EXACT [] synonym: "wing prehair outgrowth" RELATED [] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035319 name: imaginal disc-derived wing hair elongation namespace: biological_process def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234] synonym: "wing hair elongation" EXACT [] synonym: "wing prehair extension" RELATED [] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035320 name: imaginal disc-derived wing hair site selection namespace: biological_process def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] synonym: "prehair localization" RELATED [] synonym: "wing hair site selection" EXACT [] is_a: GO:0022606 ! establishment of proximal/distal cell polarity relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation [Term] id: GO:0035321 name: maintenance of imaginal disc-derived wing hair orientation namespace: biological_process def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220] synonym: "maintenance of wing hair orientation" EXACT [] is_a: GO:0009954 ! proximal/distal pattern formation relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0035322 name: mesenchymal cell migration involved in limb bud formation namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0090497 ! mesenchymal cell migration intersection_of: part_of GO:0060174 ! limb bud formation relationship: part_of GO:0090496 ! mesenchyme migration involved in limb bud formation created_by: rfoulger creation_date: 2010-02-24T02:05:14Z [Term] id: GO:0035323 name: male germline ring canal namespace: cellular_component def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420] synonym: "spermatocyte ring canal" NARROW [] synonym: "testicular ring canal" NARROW [] is_a: GO:0045172 ! germline ring canal created_by: rfoulger creation_date: 2010-02-25T11:05:14Z [Term] id: GO:0035324 name: female germline ring canal namespace: cellular_component def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420] synonym: "nurse cell ring canal" NARROW [] synonym: "ovarian ring canal" NARROW [] is_a: GO:0045172 ! germline ring canal created_by: rfoulger creation_date: 2010-02-25T11:06:41Z [Term] id: GO:0035325 name: Toll-like receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341] synonym: "TLR binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding created_by: rfoulger creation_date: 2010-02-26T10:11:55Z [Term] id: GO:0035326 name: cis-regulatory region binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) and which enhances transcription from that promoter." [GOC:sart, GOC:txnOH, SO:0000165] synonym: "enhancer binding" RELATED [] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: rfoulger creation_date: 2010-02-26T10:17:00Z [Term] id: GO:0035327 name: transcriptionally active chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872] is_a: GO:0000785 ! chromatin created_by: rfoulger creation_date: 2010-02-26T10:23:02Z [Term] id: GO:0035328 name: transcriptionally silent chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872] synonym: "transcriptionally inactive chromatin" EXACT [] is_a: GO:0000785 ! chromatin created_by: rfoulger creation_date: 2010-02-26T10:24:13Z [Term] id: GO:0035329 name: hippo signaling namespace: biological_process def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423] synonym: "hippo signal transduction" EXACT [GOC:signaling] synonym: "hippo signaling cascade" RELATED [GOC:signaling] synonym: "hippo signaling pathway" EXACT [] synonym: "hippo signalling cascade" RELATED [GOC:mah] synonym: "Salvador-Warts-Hippo signaling pathway" NARROW [] synonym: "SWH pathway" NARROW [] is_a: GO:0035556 ! intracellular signal transduction created_by: rfoulger creation_date: 2010-02-26T10:43:33Z [Term] id: GO:0035330 name: regulation of hippo signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "regulation of hippo signaling cascade" RELATED [GOC:signaling] synonym: "regulation of hippo signaling pathway" EXACT [] synonym: "regulation of hippo signalling cascade" RELATED [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035329 ! hippo signaling relationship: regulates GO:0035329 ! hippo signaling created_by: rfoulger creation_date: 2010-02-26T10:53:05Z [Term] id: GO:0035331 name: negative regulation of hippo signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "negative regulation of hippo signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of hippo signaling pathway" EXACT [] synonym: "negative regulation of hippo signalling cascade" RELATED [GOC:mah] is_a: GO:0035330 ! regulation of hippo signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035329 ! hippo signaling relationship: negatively_regulates GO:0035329 ! hippo signaling created_by: rfoulger creation_date: 2010-02-26T10:54:19Z [Term] id: GO:0035332 name: positive regulation of hippo signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf] synonym: "positive regulation of hippo signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of hippo signaling pathway" EXACT [] synonym: "positive regulation of hippo signalling cascade" RELATED [GOC:mah] is_a: GO:0035330 ! regulation of hippo signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035329 ! hippo signaling relationship: positively_regulates GO:0035329 ! hippo signaling created_by: rfoulger creation_date: 2010-02-26T10:54:59Z [Term] id: GO:0035333 name: Notch receptor processing, ligand-dependent namespace: biological_process def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094] synonym: "Notch S2 cleavage" NARROW [PMID:12651094] synonym: "Notch S3 cleavage" NARROW [PMID:12651094] is_a: GO:0031293 ! membrane protein intracellular domain proteolysis relationship: part_of GO:0007219 ! Notch signaling pathway relationship: part_of GO:0007220 ! Notch receptor processing created_by: rfoulger creation_date: 2010-02-26T02:31:31Z [Term] id: GO:0035334 name: Notch receptor processing, ligand-independent namespace: biological_process def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [GOC:bf, PMID:12651094] synonym: "Notch S1 cleavage" NARROW [PMID:12651094] is_a: GO:0016485 ! protein processing relationship: part_of GO:0007220 ! Notch receptor processing created_by: rfoulger creation_date: 2010-02-26T02:32:46Z [Term] id: GO:0035335 name: peptidyl-tyrosine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] is_a: GO:0006470 ! protein dephosphorylation created_by: rfoulger creation_date: 2010-03-01T01:09:14Z [Term] id: GO:0035336 name: long-chain fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] synonym: "long-chain fatty acyl CoA metabolic process" EXACT [] synonym: "long-chain fatty acyl-CoA metabolism" EXACT [] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: rfoulger creation_date: 2010-03-02T11:01:43Z [Term] id: GO:0035337 name: fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] synonym: "fatty acyl CoA metabolic process" EXACT [] synonym: "fatty-acyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process created_by: rfoulger creation_date: 2010-03-02T11:05:48Z [Term] id: GO:0035338 name: long-chain fatty-acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] synonym: "long-chain fatty acyl CoA biosynthetic process" EXACT [] synonym: "long-chain fatty-acyl-CoA anabolism" EXACT [] synonym: "long-chain fatty-acyl-CoA biosynthesis" EXACT [] synonym: "long-chain fatty-acyl-CoA formation" EXACT [] synonym: "long-chain fatty-acyl-CoA synthesis" EXACT [] is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process created_by: rfoulger creation_date: 2010-03-02T11:07:15Z [Term] id: GO:0035339 name: SPOTS complex namespace: cellular_component def: "A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis." [PMID:20182505] synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" NARROW [] is_a: GO:0017059 ! serine C-palmitoyltransferase complex created_by: rfoulger creation_date: 2010-03-03T10:28:42Z [Term] id: GO:0035340 name: inosine transport namespace: biological_process def: "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:19135251] synonym: "hypoxanthine riboside transport" EXACT [] is_a: GO:0015858 ! nucleoside transport created_by: rfoulger creation_date: 2010-03-04T10:00:58Z [Term] id: GO:0035341 name: regulation of inosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032245 ! regulation of purine nucleoside transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035340 ! inosine transport relationship: regulates GO:0035340 ! inosine transport created_by: rfoulger creation_date: 2010-03-04T10:03:51Z [Term] id: GO:0035342 name: positive regulation of inosine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "positive regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0035341 ! regulation of inosine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035340 ! inosine transport relationship: positively_regulates GO:0035340 ! inosine transport created_by: rfoulger creation_date: 2010-03-04T10:05:03Z [Term] id: GO:0035343 name: negative regulation of inosine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "negative regulation of hypoxanthine riboside transport" EXACT [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0035341 ! regulation of inosine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035340 ! inosine transport relationship: negatively_regulates GO:0035340 ! inosine transport created_by: rfoulger creation_date: 2010-03-04T10:06:07Z [Term] id: GO:0035344 name: hypoxanthine transport namespace: biological_process def: "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sl] synonym: "6-hydroxypurine transport" EXACT [] synonym: "hypoxanthine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport created_by: rfoulger creation_date: 2010-03-04T10:39:55Z [Term] id: GO:0035345 name: regulation of hypoxanthine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035344 ! hypoxanthine transport relationship: regulates GO:0035344 ! hypoxanthine transport created_by: rfoulger creation_date: 2010-03-04T10:42:04Z [Term] id: GO:0035346 name: positive regulation of hypoxanthine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "positive regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0035345 ! regulation of hypoxanthine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035344 ! hypoxanthine transport relationship: positively_regulates GO:0035344 ! hypoxanthine transport created_by: rfoulger creation_date: 2010-03-04T10:42:48Z [Term] id: GO:0035347 name: negative regulation of hypoxanthine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] synonym: "negative regulation of 6-hydroxypurine transport" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0035345 ! regulation of hypoxanthine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035344 ! hypoxanthine transport relationship: negatively_regulates GO:0035344 ! hypoxanthine transport created_by: rfoulger creation_date: 2010-03-04T10:43:53Z [Term] id: GO:0035348 name: acetyl-CoA transmembrane transport namespace: biological_process def: "The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GO:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "acetyl-CoA membrane transport" EXACT [] is_a: GO:0015876 ! acetyl-CoA transport is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport is_a: GO:0098656 ! anion transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:42:23Z [Term] id: GO:0035349 name: coenzyme A transmembrane transport namespace: biological_process def: "The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "coenzyme A membrane transport" EXACT [] is_a: GO:0015880 ! coenzyme A transport is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport is_a: GO:0098656 ! anion transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:44:33Z [Term] id: GO:0035350 name: FAD transmembrane transport namespace: biological_process def: "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "FAD membrane transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0051181 ! cofactor transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:45:11Z [Term] id: GO:0035351 name: heme transmembrane transport namespace: biological_process def: "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "heme membrane transport" EXACT [] is_a: GO:0015886 ! heme transport is_a: GO:0034755 ! iron ion transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:45:46Z [Term] id: GO:0035352 name: NAD transmembrane transport namespace: biological_process def: "The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "NAD membrane transport" EXACT [] is_a: GO:0043132 ! NAD transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:46:20Z [Term] id: GO:0035353 name: nicotinamide mononucleotide transmembrane transport namespace: biological_process def: "The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [GOC:bf, ISBN:0721662544] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nicotinamide mononucleotide membrane transport" EXACT [] is_a: GO:0015890 ! nicotinamide mononucleotide transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: rfoulger creation_date: 2010-03-04T03:46:55Z [Term] id: GO:0035354 name: Toll-like receptor 1-Toll-like receptor 2 protein complex namespace: cellular_component alt_id: GO:0038125 def: "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)." [GOC:add, GOC:signaling, PMID:17889651, PMID:21481769] synonym: "TLR1-TLR2 protein complex" EXACT [] synonym: "TLR1:TLR2 complex" EXACT [] synonym: "TLR2:TLR1 heterodimer" EXACT [GOC:bf] synonym: "toll-like receptor TLR1:TLR2 heterodimeric complex" EXACT [GOC:bf] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2010-03-04T04:35:44Z [Term] id: GO:0035355 name: Toll-like receptor 2-Toll-like receptor 6 protein complex namespace: cellular_component alt_id: GO:0038126 def: "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6)." [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769] synonym: "TLR2-TLR6 protein complex" EXACT [] synonym: "TLR2:TLR6 heterodimer" EXACT [GOC:bf] synonym: "TLR6:TLR2 complex" EXACT [] synonym: "toll-like receptor TLR6:TLR2 heterodimeric complex" EXACT [GOC:bf] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2010-03-04T04:37:00Z [Term] id: GO:0035356 name: cellular triglyceride homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment." [GOC:BHF] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0070328 ! triglyceride homeostasis created_by: rfoulger creation_date: 2010-03-05T10:28:11Z [Term] id: GO:0035357 name: peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes." [GOC:BHF, PMID:18221086] synonym: "peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "PPAR signaling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor signaling pathway created_by: rfoulger creation_date: 2010-03-05T10:30:10Z [Term] id: GO:0035358 name: regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway relationship: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway created_by: rfoulger creation_date: 2010-03-05T10:39:37Z [Term] id: GO:0035359 name: negative regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "negative regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "negative regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway relationship: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway created_by: rfoulger creation_date: 2010-03-05T10:41:35Z [Term] id: GO:0035360 name: positive regulation of peroxisome proliferator activated receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] synonym: "positive regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] synonym: "positive regulation of PPAR signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway relationship: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway created_by: rfoulger creation_date: 2010-03-05T10:43:10Z [Term] id: GO:0035361 name: Cul8-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins." [GOC:krc, PMID:20139071] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex created_by: rfoulger creation_date: 2010-03-05T02:41:12Z [Term] id: GO:0035362 name: protein-DNA ISRE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, PMID:11747630] synonym: "protein-DNA interferon-stimulated response element complex assembly" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly created_by: rfoulger creation_date: 2010-03-10T10:40:09Z [Term] id: GO:0035363 name: histone locus body namespace: cellular_component def: "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] synonym: "HLB" EXACT [PMID:16533947, PMID:18927579, PMID:19620235] is_a: GO:0016604 ! nuclear body created_by: rfoulger creation_date: 2010-03-10T10:44:01Z [Term] id: GO:0035364 name: thymine transport namespace: biological_process def: "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO:sl] synonym: "5-methyluracil transport" EXACT [] synonym: "thymine transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine nucleobase transport created_by: rfoulger creation_date: 2010-03-11T10:20:24Z [Term] id: GO:0035365 name: regulation of thymine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035364 ! thymine transport relationship: regulates GO:0035364 ! thymine transport created_by: rfoulger creation_date: 2010-03-11T10:22:54Z [Term] id: GO:0035366 name: negative regulation of thymine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "negative regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0035365 ! regulation of thymine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035364 ! thymine transport relationship: negatively_regulates GO:0035364 ! thymine transport created_by: rfoulger creation_date: 2010-03-11T10:23:42Z [Term] id: GO:0035367 name: positive regulation of thymine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] synonym: "positive regulation of 5-methyluracil transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0035365 ! regulation of thymine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035364 ! thymine transport relationship: positively_regulates GO:0035364 ! thymine transport created_by: rfoulger creation_date: 2010-03-11T10:24:25Z [Term] id: GO:0035368 name: selenocysteine insertion sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958] synonym: "SECIS binding" EXACT [] is_a: GO:0003729 ! mRNA binding created_by: rfoulger creation_date: 2010-03-11T10:42:28Z [Term] id: GO:0035369 name: pre-B cell receptor complex namespace: cellular_component def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522] comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome. synonym: "pre-BCR" EXACT [] is_a: GO:0098796 ! membrane protein complex created_by: rfoulger creation_date: 2010-03-11T10:46:10Z [Term] id: GO:0035370 name: UBC13-UEV1A complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784] is_a: GO:0031371 ! ubiquitin conjugating enzyme complex created_by: rfoulger creation_date: 2010-03-11T10:53:09Z [Term] id: GO:0035371 name: microtubule plus-end namespace: cellular_component def: "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] synonym: "growing microtubule plus end" EXACT [] synonym: "microtubule plus end" EXACT [] is_a: GO:1990752 ! microtubule end created_by: rfoulger creation_date: 2010-03-11T10:55:00Z [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton created_by: rfoulger creation_date: 2010-03-11T11:00:56Z [Term] id: GO:0035373 name: chondroitin sulfate proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit." [GOC:kmv, ISBN:0198506732] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0043168 ! anion binding is_a: GO:0043394 ! proteoglycan binding is_a: GO:1901681 ! sulfur compound binding created_by: rfoulger creation_date: 2010-03-12T10:23:55Z [Term] id: GO:0035374 name: chondroitin sulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding created_by: rfoulger creation_date: 2010-03-12T10:25:34Z [Term] id: GO:0035375 name: zymogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732] synonym: "proenzyme binding" NARROW [ISBN:0198506732] is_a: GO:0019899 ! enzyme binding created_by: rfoulger creation_date: 2010-03-18T10:50:35Z [Term] id: GO:0035376 name: sterol import namespace: biological_process def: "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, PMID:19793923] synonym: "sterol influx" EXACT [PMID:12077145] synonym: "sterol uptake" EXACT [PMID:12077145] is_a: GO:0015918 ! sterol transport created_by: rfoulger creation_date: 2010-03-18T10:53:01Z [Term] id: GO:0035377 name: transepithelial water transport namespace: biological_process def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf] is_a: GO:0006833 ! water transport is_a: GO:0042045 ! epithelial fluid transport created_by: rfoulger creation_date: 2010-03-18T10:55:38Z [Term] id: GO:0035378 name: carbon dioxide transmembrane transport namespace: biological_process def: "The process in which carbon dioxide (CO2) is transported across a membrane." [GOC:yaf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbon dioxide membrane transport" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015670 ! carbon dioxide transport created_by: rfoulger creation_date: 2010-03-18T11:17:54Z [Term] id: GO:0035379 name: carbon dioxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other." [GOC:yaf] xref: Reactome:R-HSA-1237042 "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol" xref: Reactome:R-HSA-1237069 "RhAG passively translocates carbon dioxide from the extracellular region to the cytosol" xref: Reactome:R-HSA-1247645 "RhAG passively translocates carbon dioxide from the cytosol to the extracellular region" xref: Reactome:R-HSA-1247649 "AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region" is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0035378 ! carbon dioxide transmembrane transport created_by: rfoulger creation_date: 2010-03-18T11:19:38Z [Term] id: GO:0035380 name: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pde] synonym: "very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2010-03-18T11:23:05Z [Term] id: GO:0035381 name: ATP-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022834 ! ligand-gated channel activity created_by: rfoulger creation_date: 2010-03-18T01:21:45Z [Term] id: GO:0035382 name: sterol transmembrane transport namespace: biological_process def: "The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "sterol membrane transport" EXACT [] is_a: GO:0015918 ! sterol transport is_a: GO:0055085 ! transmembrane transport created_by: rfoulger creation_date: 2010-03-18T01:24:39Z [Term] id: GO:0035383 name: thioester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester] synonym: "thioester metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: rfoulger creation_date: 2010-03-18T01:48:12Z [Term] id: GO:0035384 name: thioester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester] synonym: "thioester anabolism" EXACT [] synonym: "thioester biosynthesis" EXACT [] synonym: "thioester formation" EXACT [] synonym: "thioester synthesis" EXACT [] is_a: GO:0035383 ! thioester metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: rfoulger creation_date: 2010-03-18T01:52:11Z [Term] id: GO:0035385 name: Roundabout signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] synonym: "ROBO signaling pathway" EXACT [] synonym: "ROBO/SLIT signaling pathway" EXACT [] synonym: "Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2010-03-18T02:38:31Z [Term] id: GO:0035386 name: regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035385 ! Roundabout signaling pathway relationship: regulates GO:0035385 ! Roundabout signaling pathway created_by: rfoulger creation_date: 2010-03-18T02:39:24Z [Term] id: GO:0035387 name: negative regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "negative regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0035386 ! regulation of Roundabout signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035385 ! Roundabout signaling pathway relationship: negatively_regulates GO:0035385 ! Roundabout signaling pathway created_by: rfoulger creation_date: 2010-03-18T02:40:00Z [Term] id: GO:0035388 name: positive regulation of Roundabout signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] synonym: "positive regulation of Roundabout signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0035386 ! regulation of Roundabout signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035385 ! Roundabout signaling pathway relationship: positively_regulates GO:0035385 ! Roundabout signaling pathway created_by: rfoulger creation_date: 2010-03-18T02:41:16Z [Term] id: GO:0035389 name: establishment of chromatin silencing at silent mating-type cassette namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci." [GOC:vw] is_a: GO:0006343 ! establishment of chromatin silencing relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: rfoulger creation_date: 2010-03-22T10:23:14Z [Term] id: GO:0035390 name: establishment of chromatin silencing at telomere namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at the telomere." [GOC:vw] is_a: GO:0006343 ! establishment of chromatin silencing intersection_of: GO:0006343 ! establishment of chromatin silencing intersection_of: occurs_in GO:0000781 ! chromosome, telomeric region relationship: occurs_in GO:0000781 ! chromosome, telomeric region relationship: part_of GO:0006348 ! chromatin silencing at telomere created_by: rfoulger creation_date: 2010-03-22T10:24:07Z [Term] id: GO:0035391 name: maintenance of chromatin silencing at silent mating-type cassette namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci." [GOC:vw] is_a: GO:0006344 ! maintenance of chromatin silencing relationship: part_of GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: rfoulger creation_date: 2010-03-22T10:25:14Z [Term] id: GO:0035392 name: maintenance of chromatin silencing at telomere namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere." [GOC:vw] is_a: GO:0006344 ! maintenance of chromatin silencing relationship: part_of GO:0006348 ! chromatin silencing at telomere created_by: rfoulger creation_date: 2010-03-22T10:25:57Z [Term] id: GO:0035393 name: chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] synonym: "CXCL9 production" EXACT [] synonym: "MIG production" EXACT [] synonym: "Monokine induced by gamma interferon production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: rfoulger creation_date: 2010-03-23T10:03:20Z [Term] id: GO:0035394 name: regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "regulation of CXCL9 production" EXACT [] synonym: "regulation of MIG production" EXACT [] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production relationship: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production created_by: rfoulger creation_date: 2010-03-23T10:06:19Z [Term] id: GO:0035395 name: negative regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "negative regulation of CXCL9 production" EXACT [] synonym: "negative regulation of MIG production" EXACT [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production relationship: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production created_by: rfoulger creation_date: 2010-03-23T10:06:44Z [Term] id: GO:0035396 name: positive regulation of chemokine (C-X-C motif) ligand 9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] synonym: "positive regulation of CXCL9 production" EXACT [] synonym: "positive regulation of MIG production" EXACT [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production relationship: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production created_by: rfoulger creation_date: 2010-03-23T10:07:17Z [Term] id: GO:0035397 name: helper T cell enhancement of adaptive immune response namespace: biological_process def: "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." [GOC:add] synonym: "provision of T cell help" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains created_by: rfoulger creation_date: 2010-03-23T10:38:31Z [Term] id: GO:0035398 name: helper T cell enhancement of T cell mediated immune response namespace: biological_process def: "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] synonym: "helper T cell enhancement of T cell mediated immunity" EXACT [] synonym: "provision of T cell help to T cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response created_by: rfoulger creation_date: 2010-03-23T10:40:00Z [Term] id: GO:0035399 name: helper T cell enhancement of B cell mediated immune response namespace: biological_process def: "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] synonym: "helper T cell enhancement of B cell mediated immunity" EXACT [] synonym: "provision of T cell help to B cell" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response created_by: rfoulger creation_date: 2010-03-23T10:41:46Z [Term] id: GO:0035400 name: histone tyrosine kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] synonym: "histone-tyrosine kinase activity" EXACT [] is_a: GO:0004715 ! non-membrane spanning protein tyrosine kinase activity is_a: GO:0035173 ! histone kinase activity relationship: part_of GO:0035406 ! histone-tyrosine phosphorylation created_by: rfoulger creation_date: 2010-03-24T09:59:15Z [Term] id: GO:0035401 name: histone kinase activity (H3-Y41 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3." [GOC:bf] synonym: "histone tyrosine kinase activity (H3-Y41 specific)" EXACT [] synonym: "histone-tyrosine kinase activity (H3-Y41 specific)" EXACT [] is_a: GO:0035400 ! histone tyrosine kinase activity relationship: part_of GO:0035409 ! histone H3-Y41 phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:01:14Z [Term] id: GO:0035402 name: histone kinase activity (H3-T11 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3." [GOC:bf] synonym: "histone threonine kinase activity (H3-T11 specific)" EXACT [] synonym: "histone-threonine kinase activity (H3-T11 specific)" EXACT [] is_a: GO:0035184 ! histone threonine kinase activity relationship: part_of GO:0035407 ! histone H3-T11 phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:04:40Z [Term] id: GO:0035403 name: histone kinase activity (H3-T6 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3." [GOC:bf] synonym: "histone threonine kinase activity (H3-T6 specific)" EXACT [] synonym: "histone-threonine kinase activity (H3-T6 specific)" EXACT [] is_a: GO:0035184 ! histone threonine kinase activity relationship: part_of GO:0035408 ! histone H3-T6 phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:05:39Z [Term] id: GO:0035404 name: histone-serine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf] synonym: "histone serine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018105 ! peptidyl-serine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:08:25Z [Term] id: GO:0035405 name: histone-threonine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a threonine residue." [GOC:bf] synonym: "histone threonine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018107 ! peptidyl-threonine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:09:21Z [Term] id: GO:0035406 name: histone-tyrosine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a tyrosine residue." [GOC:bf] synonym: "histone tyrosine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:10:16Z [Term] id: GO:0035407 name: histone H3-T11 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." [GOC:bf] is_a: GO:0035405 ! histone-threonine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:12:01Z [Term] id: GO:0035408 name: histone H3-T6 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone." [GOC:bf] is_a: GO:0035405 ! histone-threonine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:12:51Z [Term] id: GO:0035409 name: histone H3-Y41 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf] is_a: GO:0035406 ! histone-tyrosine phosphorylation created_by: rfoulger creation_date: 2010-03-24T10:13:13Z [Term] id: GO:0035410 name: dihydrotestosterone 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH." [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] xref: EC:1.1.1.51 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2010-03-24T10:48:41Z [Term] id: GO:0035415 name: obsolete regulation of mitotic prometaphase namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "regulation of mitotic prometaphase" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T10:52:08Z [Term] id: GO:0035416 name: obsolete positive regulation of mitotic prometaphase namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "positive regulation of mitotic prometaphase" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T10:52:55Z [Term] id: GO:0035417 name: obsolete negative regulation of mitotic prometaphase namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "negative regulation of mitotic prometaphase" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T10:53:42Z [Term] id: GO:0035418 name: protein localization to synapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] synonym: "protein localisation to synapse" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization created_by: rfoulger creation_date: 2010-03-29T10:58:53Z [Term] id: GO:0035419 name: obsolete activation of MAPK activity involved in innate immune response namespace: biological_process def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] comment: This term was obsoleted because it should be represented as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/18000. is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T01:25:24Z [Term] id: GO:0035420 name: MAPK cascade involved in innate immune response namespace: biological_process def: "A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] synonym: "MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling] is_a: GO:0000165 ! MAPK cascade intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0045087 ! innate immune response relationship: part_of GO:0045087 ! innate immune response created_by: rfoulger creation_date: 2010-03-29T01:25:59Z [Term] id: GO:0035421 name: obsolete activation of MAPKK activity involved in innate immune response namespace: biological_process def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] comment: This term was obsoleted because it should be represented as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/18000. is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T01:26:44Z [Term] id: GO:0035422 name: obsolete activation of MAPKKK activity involved in innate immune response namespace: biological_process def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] comment: This term was obsoleted because it should be represented as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/18000. is_obsolete: true created_by: rfoulger creation_date: 2010-03-29T01:27:38Z [Term] id: GO:0035423 name: inactivation of MAPK activity involved in innate immune response namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] is_a: GO:0000188 ! inactivation of MAPK activity is_a: GO:0002766 ! innate immune response-inhibiting signal transduction created_by: rfoulger creation_date: 2010-03-29T01:28:59Z [Term] id: GO:0035424 name: obsolete MAPK import into nucleus involved in innate immune response namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "nuclear translocation of MAPK involved in innate immune response" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 created_by: rfoulger creation_date: 2010-03-29T01:29:36Z [Term] id: GO:0035425 name: autocrine signaling namespace: biological_process def: "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type." [GOC:bf, ISBN:3527303782] synonym: "autocrine signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling created_by: rfoulger creation_date: 2010-03-29T02:15:52Z [Term] id: GO:0035426 name: extracellular matrix-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between the extracellular matrix and a cell." [GOC:bf] synonym: "cell-extracellular matrix signalling" EXACT [] synonym: "extracellular matrix-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling created_by: rfoulger creation_date: 2010-03-29T02:26:54Z [Term] id: GO:0035429 name: gluconate transmembrane transport namespace: biological_process alt_id: GO:0015725 def: "The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose." [GOC:vw, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "gluconate membrane transport" EXACT [] synonym: "gluconate transport" RELATED [] is_a: GO:0042873 ! aldonate transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:33:46Z [Term] id: GO:0035430 name: regulation of gluconate transmembrane transport namespace: biological_process alt_id: GO:0032893 def: "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] synonym: "regulation of gluconate membrane transport" EXACT [] synonym: "regulation of gluconate transport" RELATED [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035429 ! gluconate transmembrane transport relationship: regulates GO:0035429 ! gluconate transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:37:18Z [Term] id: GO:0035431 name: negative regulation of gluconate transmembrane transport namespace: biological_process alt_id: GO:0032894 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] synonym: "down regulation of gluconate transport" EXACT [] synonym: "down-regulation of gluconate transport" EXACT [] synonym: "downregulation of gluconate transport" EXACT [] synonym: "inhibition of gluconate transport" NARROW [] synonym: "negative regulation of gluconate membrane transport" EXACT [] synonym: "negative regulation of gluconate transport" RELATED [] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0035430 ! regulation of gluconate transmembrane transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035429 ! gluconate transmembrane transport relationship: negatively_regulates GO:0035429 ! gluconate transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:39:08Z [Term] id: GO:0035432 name: positive regulation of gluconate transmembrane transport namespace: biological_process alt_id: GO:0032895 def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] synonym: "activation of gluconate transport" NARROW [] synonym: "induction of gluconate transport" NARROW [] synonym: "positive regulation of gluconate membrane transport" EXACT [] synonym: "positive regulation of gluconate transport" RELATED [] synonym: "stimulation of gluconate transport" NARROW [] synonym: "up regulation of gluconate transport" EXACT [] synonym: "up-regulation of gluconate transport" EXACT [] synonym: "upregulation of gluconate transport" EXACT [] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0035430 ! regulation of gluconate transmembrane transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035429 ! gluconate transmembrane transport relationship: positively_regulates GO:0035429 ! gluconate transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:39:58Z [Term] id: GO:0035433 name: acetate transmembrane transport namespace: biological_process def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "acetate membrane transport" EXACT [] is_a: GO:0006846 ! acetate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: rfoulger creation_date: 2010-04-08T10:59:01Z [Term] id: GO:0035434 name: copper ion transmembrane transport namespace: biological_process alt_id: GO:1901473 def: "The directed movement of copper cation across a membrane." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "copper cation transmembrane transport" EXACT [] synonym: "copper ion membrane transport" EXACT [] is_a: GO:0006825 ! copper ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: rfoulger creation_date: 2010-04-08T11:03:23Z [Term] id: GO:0035435 name: phosphate ion transmembrane transport namespace: biological_process def: "The process in which a phosphate is transported across a membrane." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "phosphate ion membrane transport" EXACT [] is_a: GO:0006817 ! phosphate ion transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: rfoulger creation_date: 2010-04-08T11:24:06Z [Term] id: GO:0035436 name: triose phosphate transmembrane transport namespace: biological_process def: "The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester." [GOC:bf, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "triose phosphate membrane transport" EXACT [] synonym: "triose phosphate transmembrane transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015717 ! triose phosphate transport is_a: GO:0098656 ! anion transmembrane transport created_by: rfoulger creation_date: 2010-04-08T02:54:07Z [Term] id: GO:0035437 name: maintenance of protein localization in endoplasmic reticulum namespace: biological_process def: "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw] synonym: "maintenance of protein localisation in endoplasmic reticulum" EXACT [GOC:mah] synonym: "maintenance of protein localization in ER" EXACT [] synonym: "maintenance of protein location in endoplasmic reticulum" EXACT [] synonym: "maintenance of protein location in ER" EXACT [] synonym: "protein-endoplasmic reticulum retention" EXACT [] synonym: "protein-ER retention" EXACT [] synonym: "retention of protein in endoplasmic reticulum" EXACT [] synonym: "retention of protein in ER" EXACT [] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum relationship: occurs_in GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum created_by: rfoulger creation_date: 2010-04-09T10:39:49Z [Term] id: GO:0035438 name: cyclic-di-GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [GOC:bf] synonym: "3',5'-cyclic di-GMP binding" EXACT [] synonym: "c-di-GMP binding" EXACT [] synonym: "cyclic dinucleotide di-GMP binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding created_by: rfoulger creation_date: 2010-04-09T02:40:17Z [Term] id: GO:0035439 name: halimadienyl-diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate." [EC:5.5.1.16] synonym: "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)" EXACT [EC:5.5.1.16] synonym: "halimadienyl diphosphate synthase activity" EXACT [EC:5.5.1.16] xref: EC:5.5.1.16 xref: RHEA:25621 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity created_by: rfoulger creation_date: 2010-04-09T02:59:35Z [Term] id: GO:0035440 name: tuberculosinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria." [MetaCyc:PWY-5935] synonym: "halima-5,6,dien-15-ol biosynthesis" EXACT [] synonym: "halima-5,6,dien-15-ol biosynthetic process" EXACT [] synonym: "tuberculosinol biosynthesis" EXACT [] xref: MetaCyc:PWY-5935 is_a: GO:0016102 ! diterpenoid biosynthetic process created_by: rfoulger creation_date: 2010-04-09T03:36:19Z [Term] id: GO:0035441 name: cell migration involved in vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0001570 ! vasculogenesis relationship: part_of GO:0001570 ! vasculogenesis created_by: rfoulger creation_date: 2010-04-09T03:53:01Z [Term] id: GO:0035442 name: dipeptide transmembrane transport namespace: biological_process def: "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "dipeptide membrane transport" EXACT [] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0042938 ! dipeptide transport created_by: rfoulger creation_date: 2010-04-13T09:18:33Z [Term] id: GO:0035443 name: tripeptide transmembrane transport namespace: biological_process def: "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "tripeptide membrane transport" EXACT [] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0042939 ! tripeptide transport created_by: rfoulger creation_date: 2010-04-13T09:20:25Z [Term] id: GO:0035444 name: nickel cation transmembrane transport namespace: biological_process def: "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nickel cation membrane transport" EXACT [] is_a: GO:0015675 ! nickel cation transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: rfoulger creation_date: 2010-04-13T09:22:51Z [Term] id: GO:0035445 name: borate transmembrane transport namespace: biological_process def: "The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [GOC:curators] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "borate membrane transport" EXACT [] synonym: "boron transmembrane transport" RELATED [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0046713 ! borate transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: rfoulger creation_date: 2010-04-13T09:24:23Z [Term] id: GO:0035446 name: cysteine-glucosaminylinositol ligase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins." [EC:6.3.1.13, MetaCyc:RXN1G-4, PMID:12033919] synonym: "desacetylmycothiol synthase" RELATED [PMID:12033919] synonym: "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase" EXACT [EC:6.3.1.13] synonym: "MshC ligase" EXACT [EC:6.3.1.13] xref: EC:6.3.1.13 xref: MetaCyc:RXN1G-4 xref: RHEA:26176 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity created_by: rfoulger creation_date: 2010-04-14T11:33:06Z [Term] id: GO:0035447 name: mycothiol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol." [MetaCyc:MONOMER-9684, PMID:12033919] synonym: "acetyl-CoA:Cys-GlcN-Ins acetyltransferase" EXACT [] xref: MetaCyc:MONOMER-9684 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: rfoulger creation_date: 2010-04-14T11:40:26Z [Term] id: GO:0035448 name: extrinsic component of thylakoid membrane namespace: cellular_component def: "The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to thylakoid membrane" NARROW [] synonym: "peripheral to thylakoid membrane" EXACT [] is_a: GO:0019898 ! extrinsic component of membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0042651 ! thylakoid membrane relationship: part_of GO:0042651 ! thylakoid membrane created_by: rfoulger creation_date: 2010-04-16T10:11:32Z [Term] id: GO:0035449 name: extrinsic component of plastid thylakoid membrane namespace: cellular_component def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to plastid thylakoid membrane" NARROW [] synonym: "peripheral to plastid thylakoid membrane" EXACT [] is_a: GO:0035448 ! extrinsic component of thylakoid membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0055035 ! plastid thylakoid membrane created_by: rfoulger creation_date: 2010-04-16T10:14:24Z [Term] id: GO:0035450 name: extrinsic component of lumenal side of plastid thylakoid membrane namespace: cellular_component def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to lumenal leaflet of plastid thylakoid membrane" EXACT [GOC:ab] synonym: "extrinsic to lumenal side of plastid thylakoid membrane" NARROW [] synonym: "peripheral to lumenal side of plastid thylakoid membrane" EXACT [] is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane is_a: GO:0035453 ! extrinsic component of plastid inner membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098570 ! stromal side of plastid inner membrane relationship: part_of GO:0098570 ! stromal side of plastid inner membrane created_by: rfoulger creation_date: 2010-04-16T10:17:25Z [Term] id: GO:0035451 name: extrinsic component of stromal side of plastid thylakoid membrane namespace: cellular_component def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to stromal leaflet of plastid thylakoid membrane" EXACT [GOC:ab] synonym: "extrinsic to stromal side of plastid thylakoid membrane" NARROW [] synonym: "peripheral to stromal side of plastid thylakoid membrane" EXACT [] is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098572 ! stromal side of plastid thylakoid membrane relationship: part_of GO:0098572 ! stromal side of plastid thylakoid membrane created_by: rfoulger creation_date: 2010-04-16T10:18:01Z [Term] id: GO:0035452 name: extrinsic component of plastid membrane namespace: cellular_component def: "The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to plastid membrane" NARROW [] synonym: "peripheral to plastid membrane" EXACT [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0042170 ! plastid membrane relationship: part_of GO:0042170 ! plastid membrane created_by: rfoulger creation_date: 2010-04-16T10:19:33Z [Term] id: GO:0035453 name: extrinsic component of plastid inner membrane namespace: cellular_component def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to plastid inner membrane" NARROW [] synonym: "peripheral to plastid inner membrane" EXACT [] is_a: GO:0035452 ! extrinsic component of plastid membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0009528 ! plastid inner membrane relationship: part_of GO:0009528 ! plastid inner membrane created_by: rfoulger creation_date: 2010-04-16T10:21:14Z [Term] id: GO:0035454 name: extrinsic component of stromal side of plastid inner membrane namespace: cellular_component def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] synonym: "extrinsic to stromal leaflet of plastid inner membrane" EXACT [GOC:ab] synonym: "extrinsic to stromal side of plastid inner membrane" NARROW [] synonym: "peripheral to stromal side of plastid inner membrane" EXACT [] is_a: GO:0035450 ! extrinsic component of lumenal side of plastid thylakoid membrane created_by: rfoulger creation_date: 2010-04-16T10:23:12Z [Term] id: GO:0035455 name: response to interferon-alpha namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PMID:11356686] synonym: "response to interferon alfa-n1" RELATED [GOC:sl] synonym: "response to interferon alfa-n3" RELATED [GOC:sl] synonym: "response to leukocyte interferon" EXACT [GOC:sl] synonym: "response to lymphoblast interferon" EXACT [GOC:sl] synonym: "response to lymphoblastoid interferon" EXACT [GOC:sl] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2010-04-16T10:57:16Z [Term] id: GO:0035456 name: response to interferon-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374, PR:000008924] synonym: "response to beta-1 interferon" RELATED [GOC:sl] synonym: "response to fiblaferon" EXACT [GOC:sl] synonym: "response to fibroblast interferon" EXACT [GOC:sl] synonym: "response to interferon beta" EXACT [GOC:hp, PR:000008924] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2010-04-16T11:06:12Z [Term] id: GO:0035457 name: cellular response to interferon-alpha namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PR:000024938] synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl] synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl] synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl] synonym: "cellular response to lymphoblast interferon" EXACT [GOC:sl] synonym: "cellular response to lymphoblastoid interferon" EXACT [GOC:sl] is_a: GO:0035455 ! response to interferon-alpha is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2010-04-16T11:08:29Z [Term] id: GO:0035458 name: cellular response to interferon-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PR:000024939] synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl] synonym: "cellular response to fiblaferon" EXACT [GOC:sl] synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl] is_a: GO:0035456 ! response to interferon-beta is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2010-04-16T11:10:40Z [Term] id: GO:0035459 name: vesicle cargo loading namespace: biological_process def: "The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:bf, GOC:lb] synonym: "cargo loading into vesicle" EXACT [] synonym: "cargo selection" EXACT [GOC:vw] is_a: GO:0006810 ! transport relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: rfoulger creation_date: 2010-04-16T01:14:06Z [Term] id: GO:0035460 name: L-ascorbate 6-phosphate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." [PMID:18097099, PMID:20359483] xref: RHEA:28803 is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: rfoulger creation_date: 2010-04-16T02:05:41Z [Term] id: GO:0035461 name: vitamin transmembrane transport namespace: biological_process def: "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vitamin membrane transport" EXACT [] is_a: GO:0051180 ! vitamin transport is_a: GO:0055085 ! transmembrane transport created_by: rfoulger creation_date: 2010-04-19T10:21:41Z [Term] id: GO:0035462 name: determination of left/right asymmetry in diencephalon namespace: biological_process def: "The establishment of the diencephalon with respect to the left and right halves." [GOC:dgh, PMID:15084459] is_a: GO:0035545 ! determination of left/right asymmetry in nervous system relationship: part_of GO:0021536 ! diencephalon development created_by: rfoulger creation_date: 2010-04-19T11:50:11Z [Term] id: GO:0035463 name: transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves." [GOC:dgh, GOC:signaling] synonym: "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: rfoulger creation_date: 2010-04-19T01:19:20Z [Term] id: GO:0035464 name: regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves." [GOC:dgh] synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry relationship: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry created_by: rfoulger creation_date: 2010-04-19T01:31:56Z [Term] id: GO:0035465 name: obsolete regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves." [GOC:dgh, PMID:15084459] comment: This term was made obsolete because it describes regulation of the nodal signaling pathway. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_obsolete: true replaced_by: GO:1900175 created_by: rfoulger creation_date: 2010-04-19T01:36:23Z [Term] id: GO:0035469 name: determination of pancreatic left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism." [GOC:dgh, PMID:12702646] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0031016 ! pancreas development created_by: rfoulger creation_date: 2010-04-22T10:47:15Z [Term] id: GO:0035470 name: positive regulation of vascular wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0090303 ! positive regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061042 ! vascular wound healing relationship: positively_regulates GO:0061042 ! vascular wound healing created_by: rfoulger creation_date: 2010-04-22T10:49:09Z [Term] id: GO:0035471 name: luteinizing hormone signaling pathway involved in ovarian follicle development namespace: biological_process def: "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:bf] synonym: "luteinizing hormone signalling pathway involved in ovarian follicle development" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0042700 ! luteinizing hormone signaling pathway intersection_of: GO:0042700 ! luteinizing hormone signaling pathway intersection_of: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0001541 ! ovarian follicle development created_by: rfoulger creation_date: 2010-04-22T04:43:20Z [Term] id: GO:0035472 name: choriogonadotropin hormone receptor activity namespace: molecular_function def: "Combining with the choriogonadotropin hormone to initiate a change in cell activity." [GOC:bf, ISBN:0198506732, PMID:1922095] synonym: "CG receptor activity" EXACT [ISBN:0198506732] synonym: "chorio-gonadotrophin receptor activity" EXACT [ISBN:0198506732] synonym: "chorionic gonadotropin hormone receptor" EXACT [ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity relationship: has_part GO:0038106 ! choriogonadotropin hormone binding created_by: rfoulger creation_date: 2010-04-22T04:49:57Z [Term] id: GO:0035473 name: lipase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any lipase." [GOC:BHF] is_a: GO:0019899 ! enzyme binding created_by: rfoulger creation_date: 2010-04-22T05:28:52Z [Term] id: GO:0035474 name: selective angioblast sprouting namespace: biological_process def: "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel." [GOC:dgh, PMID:19815777] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: rfoulger creation_date: 2010-04-23T10:03:55Z [Term] id: GO:0035475 name: angioblast cell migration involved in selective angioblast sprouting namespace: biological_process def: "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations." [GOC:dgh, PMID:19815777] is_a: GO:0035476 ! angioblast cell migration intersection_of: GO:0035476 ! angioblast cell migration intersection_of: part_of GO:0035474 ! selective angioblast sprouting relationship: part_of GO:0035474 ! selective angioblast sprouting created_by: rfoulger creation_date: 2010-04-23T10:04:30Z [Term] id: GO:0035476 name: angioblast cell migration namespace: biological_process def: "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis." [GOC:dgh, PMID:19815777] is_a: GO:0016477 ! cell migration relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: rfoulger creation_date: 2010-04-23T10:06:32Z [Term] id: GO:0035477 name: regulation of angioblast cell migration involved in selective angioblast sprouting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting." [GOC:dgh, PMID:19815777] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030334 ! regulation of cell migration is_a: GO:1901342 ! regulation of vasculature development relationship: regulates GO:0035475 ! angioblast cell migration involved in selective angioblast sprouting created_by: rfoulger creation_date: 2010-04-23T10:08:28Z [Term] id: GO:0035478 name: chylomicron binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE." [GOC:BHF, http://www.britannica.com/EBchecked/topic/117461/chylomicron] is_a: GO:0071813 ! lipoprotein particle binding created_by: rfoulger creation_date: 2010-04-23T10:18:52Z [Term] id: GO:0035479 name: angioblast cell migration from lateral mesoderm to midline namespace: biological_process def: "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature." [GOC:dgh, PMID:11861480] is_a: GO:0035476 ! angioblast cell migration created_by: rfoulger creation_date: 2010-04-23T10:38:05Z [Term] id: GO:0035480 name: regulation of Notch signaling pathway involved in heart induction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] synonym: "regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0090381 ! regulation of heart induction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003137 ! Notch signaling pathway involved in heart induction relationship: regulates GO:0003137 ! Notch signaling pathway involved in heart induction created_by: rfoulger creation_date: 2010-04-23T10:40:48Z [Term] id: GO:0035481 name: positive regulation of Notch signaling pathway involved in heart induction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] synonym: "positive regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0035480 ! regulation of Notch signaling pathway involved in heart induction is_a: GO:0045747 ! positive regulation of Notch signaling pathway is_a: GO:1901321 ! positive regulation of heart induction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction relationship: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction created_by: rfoulger creation_date: 2010-04-23T10:41:04Z [Term] id: GO:0035482 name: gastric motility namespace: biological_process def: "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum." [GOC:cy, ISBN:9781416032458, PMID:16139031] is_a: GO:0022600 ! digestive system process created_by: rfoulger creation_date: 2010-04-23T10:44:59Z [Term] id: GO:0035483 name: gastric emptying namespace: biological_process def: "The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:cy, ISBN:9781416032458] is_a: GO:0035482 ! gastric motility created_by: rfoulger creation_date: 2010-04-23T10:51:33Z [Term] id: GO:0035484 name: adenine/adenine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/A mispair." [GOC:bf, GOC:jh] synonym: "A/A mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T10:54:52Z [Term] id: GO:0035485 name: adenine/guanine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/G mispair." [GOC:bf, GOC:jh] synonym: "A/G mispair binding" EXACT [GOC:jh] synonym: "G/A mispair binding" RELATED [GOC:bf] synonym: "guanine-adenine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T10:55:43Z [Term] id: GO:0035486 name: cytosine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/C mispair." [GOC:bf, GOC:jh] synonym: "C/C mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T10:56:10Z [Term] id: GO:0035487 name: thymine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a T/T mispair." [GOC:bf, GOC:jh] synonym: "T/T mispair binding" EXACT [] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T10:56:37Z [Term] id: GO:0035488 name: cytosine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a C/T mispair." [GOC:bf, GOC:jh] synonym: "C/T mispair binding" EXACT [GOC:jh] synonym: "T/C mispair binding" EXACT [GOC:bf] synonym: "thymine/cytosine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T10:57:13Z [Term] id: GO:0035489 name: guanine/guanine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/G mispair." [GOC:bf, GOC:jh] synonym: "G/G mispair binding" EXACT [GOC:jh] is_a: GO:0030983 ! mismatched DNA binding created_by: rfoulger creation_date: 2010-04-23T11:16:55Z [Term] id: GO:0035490 name: regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002540 ! leukotriene production involved in inflammatory response relationship: regulates GO:0002540 ! leukotriene production involved in inflammatory response created_by: rfoulger creation_date: 2010-04-26T10:49:22Z [Term] id: GO:0035491 name: positive regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response relationship: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response created_by: rfoulger creation_date: 2010-04-26T10:50:14Z [Term] id: GO:0035492 name: negative regulation of leukotriene production involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response relationship: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response created_by: rfoulger creation_date: 2010-04-26T10:50:55Z [Term] id: GO:0035493 name: SNARE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0006906 ! vesicle fusion created_by: rfoulger creation_date: 2010-04-26T02:50:52Z [Term] id: GO:0035494 name: SNARE complex disassembly namespace: biological_process def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: rfoulger creation_date: 2010-04-26T02:54:17Z [Term] id: GO:0035495 name: regulation of SNARE complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035494 ! SNARE complex disassembly relationship: regulates GO:0035494 ! SNARE complex disassembly created_by: rfoulger creation_date: 2010-04-26T02:56:53Z [Term] id: GO:0035496 name: lipopolysaccharide-1,5-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.-, PMID:11304545] synonym: "LPS-1,5-galactosyltransferase activity" EXACT [PMID:11304545] synonym: "UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase" EXACT [PMID:11304545] xref: EC:2.4.1 is_a: GO:0035250 ! UDP-galactosyltransferase activity created_by: rfoulger creation_date: 2010-04-26T03:00:21Z [Term] id: GO:0035497 name: cAMP response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "cAMP-responsive element binding" EXACT [PMID:2875459] synonym: "CRE binding" EXACT [PMID:2900470] synonym: "cyclic AMP response element binding" EXACT [PMID:2900470] synonym: "cyclic-AMP response element binding" EXACT [PMID:2900470] synonym: "cyclic-AMP-responsive element binding" EXACT [PMID:2875459] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: rfoulger creation_date: 2010-04-29T09:26:47Z [Term] id: GO:0035498 name: carnosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752] synonym: "carnosine metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process created_by: rfoulger creation_date: 2010-04-29T01:19:52Z [Term] id: GO:0035499 name: carnosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine)." [EC:6.3.2.11, PMID:20097752] synonym: "carnosine anabolism" EXACT [] synonym: "carnosine biosynthesis" EXACT [] synonym: "carnosine formation" EXACT [] synonym: "carnosine synthesis" EXACT [] is_a: GO:0035498 ! carnosine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process created_by: rfoulger creation_date: 2010-04-29T01:20:56Z [Term] id: GO:0035500 name: MH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers." [GOC:curators] synonym: "MAD homology 2 domain binding" EXACT [Pfam:PF03166] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2010-04-29T03:14:32Z [Term] id: GO:0035501 name: MH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors." [Pfam:PF03165] synonym: "MAD homology 1 domain binding" EXACT [Pfam:PF03165] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2010-04-29T03:17:27Z [Term] id: GO:0035502 name: metanephric part of ureteric bud development namespace: biological_process def: "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0003338 ! metanephros morphogenesis created_by: rfoulger creation_date: 2010-04-29T03:22:21Z [Term] id: GO:0035503 name: ureter part of ureteric bud development namespace: biological_process def: "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0072197 ! ureter morphogenesis created_by: rfoulger creation_date: 2010-04-29T03:23:42Z [Term] id: GO:0035504 name: regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004687 ! myosin light chain kinase activity relationship: regulates GO:0004687 ! myosin light chain kinase activity created_by: rfoulger creation_date: 2010-04-30T10:47:11Z [Term] id: GO:0035505 name: positive regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0035504 ! regulation of myosin light chain kinase activity is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004687 ! myosin light chain kinase activity relationship: positively_regulates GO:0004687 ! myosin light chain kinase activity created_by: rfoulger creation_date: 2010-04-30T10:48:09Z [Term] id: GO:0035506 name: negative regulation of myosin light chain kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] is_a: GO:0035504 ! regulation of myosin light chain kinase activity is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004687 ! myosin light chain kinase activity relationship: negatively_regulates GO:0004687 ! myosin light chain kinase activity created_by: rfoulger creation_date: 2010-04-30T10:49:21Z [Term] id: GO:0035507 name: regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050115 ! myosin-light-chain-phosphatase activity relationship: regulates GO:0050115 ! myosin-light-chain-phosphatase activity created_by: rfoulger creation_date: 2010-04-30T10:53:38Z [Term] id: GO:0035508 name: positive regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity relationship: positively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity created_by: rfoulger creation_date: 2010-04-30T10:55:05Z [Term] id: GO:0035509 name: negative regulation of myosin-light-chain-phosphatase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity relationship: negatively_regulates GO:0050115 ! myosin-light-chain-phosphatase activity created_by: rfoulger creation_date: 2010-04-30T10:56:34Z [Term] id: GO:0035510 name: DNA dealkylation namespace: biological_process def: "The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf] is_a: GO:0006304 ! DNA modification created_by: rfoulger creation_date: 2010-04-30T02:20:08Z [Term] id: GO:0035511 name: oxidative DNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] is_a: GO:0070989 ! oxidative demethylation is_a: GO:0080111 ! DNA demethylation created_by: rfoulger creation_date: 2010-04-30T02:22:44Z [Term] id: GO:0035512 name: hydrolytic DNA demethylation namespace: biological_process def: "The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule." [GOC:bf] is_a: GO:0080111 ! DNA demethylation created_by: rfoulger creation_date: 2010-04-30T02:24:21Z [Term] id: GO:0035513 name: oxidative RNA demethylation namespace: biological_process def: "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] is_a: GO:0009451 ! RNA modification is_a: GO:0070989 ! oxidative demethylation created_by: rfoulger creation_date: 2010-04-30T02:25:35Z [Term] id: GO:0035514 name: DNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule." [GOC:bf] is_a: GO:0032451 ! demethylase activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0080111 ! DNA demethylation created_by: rfoulger creation_date: 2010-04-30T02:36:43Z [Term] id: GO:0035515 name: oxidative RNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] synonym: "2-oxoglutarate-dependent RNA demethylase" EXACT [PMID:17991826] xref: Reactome:R-HSA-8857692 "RNA demethylases demethylate N6-methyladenosine RNA" is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0032451 ! demethylase activity is_a: GO:0140098 ! catalytic activity, acting on RNA relationship: part_of GO:0035513 ! oxidative RNA demethylation created_by: rfoulger creation_date: 2010-04-30T02:37:08Z [Term] id: GO:0035516 name: oxidative DNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826] is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0035514 ! DNA demethylase activity relationship: part_of GO:0035511 ! oxidative DNA demethylation created_by: rfoulger creation_date: 2010-04-30T02:38:16Z [Term] id: GO:0035517 name: PR-DUB complex namespace: cellular_component def: "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459] synonym: "Polycomb repressive deubiquitinase complex" EXACT [PMID:20436459] is_a: GO:0031519 ! PcG protein complex created_by: rfoulger creation_date: 2010-05-04T04:19:02Z [Term] id: GO:0035518 name: histone H2A monoubiquitination namespace: biological_process def: "The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970] is_a: GO:0010390 ! histone monoubiquitination is_a: GO:0033522 ! histone H2A ubiquitination created_by: rfoulger creation_date: 2010-05-04T04:22:09Z [Term] id: GO:0035519 name: protein K29-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation." [PMID:17028573] synonym: "protein K29-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination created_by: rfoulger creation_date: 2010-05-04T04:25:48Z [Term] id: GO:0035520 name: monoubiquitinated protein deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated protein." [GOC:bf] synonym: "monoubiquitinated protein deubiquitinylation" EXACT [] synonym: "monoubiquitinated protein deubiquitylation" EXACT [] is_a: GO:0016579 ! protein deubiquitination created_by: rfoulger creation_date: 2010-05-04T04:28:38Z [Term] id: GO:0035521 name: monoubiquitinated histone deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated histone protein." [GOC:bf, PMID:20436459] synonym: "monoubiquitinated histone deubiquitinylation" EXACT [] synonym: "monoubiquitinated histone deubiquitylation" EXACT [] is_a: GO:0016578 ! histone deubiquitination is_a: GO:0035520 ! monoubiquitinated protein deubiquitination created_by: rfoulger creation_date: 2010-05-04T04:32:04Z [Term] id: GO:0035522 name: monoubiquitinated histone H2A deubiquitination namespace: biological_process def: "The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459] synonym: "monoubiquitinated histone H2A deubiquitinylation" EXACT [] synonym: "monoubiquitinated histone H2A deubiquitylation" EXACT [] is_a: GO:0035521 ! monoubiquitinated histone deubiquitination created_by: rfoulger creation_date: 2010-05-04T04:32:53Z [Term] id: GO:0035523 name: protein K29-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein." [GOC:bf] synonym: "protein K29-linked deubiquitinylation" EXACT [] synonym: "protein K29-linked deubiquitylation" EXACT [] is_a: GO:0016579 ! protein deubiquitination created_by: rfoulger creation_date: 2010-05-04T04:33:27Z [Term] id: GO:0035524 name: proline transmembrane transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "proline membrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015824 ! proline transport is_a: GO:0098655 ! cation transmembrane transport created_by: rfoulger creation_date: 2010-05-04T04:52:46Z [Term] id: GO:0035525 name: NF-kappaB p50/p65 complex namespace: cellular_component def: "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications. synonym: "NF-kappa B1/p65 complex" EXACT [PMID:9299584] synonym: "NF-kappa B1/RelA complex" EXACT [PMID:9299584] synonym: "NF-kappa p105/p65 complex" RELATED [PMID:9299584] synonym: "NF-kappa p105/RelA complex" RELATED [PMID:9299584] synonym: "NF-kappa p50/RelA complex" EXACT [PMID:9299584] is_a: GO:0071159 ! NF-kappaB complex created_by: rfoulger creation_date: 2010-05-05T10:45:13Z [Term] id: GO:0035526 name: retrograde transport, plasma membrane to Golgi namespace: biological_process def: "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles." [GOC:lb, PMID:17488291] is_a: GO:0016192 ! vesicle-mediated transport created_by: rfoulger creation_date: 2010-05-05T10:52:49Z [Term] id: GO:0035527 name: 3-hydroxypropionate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH." [RHEA:26438] synonym: "3-hydroxypropanoate dehydrogenase (NADP+) activity" EXACT [] synonym: "3-hydroxypropanoate:NADP+ oxidoreductase" EXACT [EC:1.1.1.298] synonym: "3-hydroxypropionate:NADP+ oxidoreductase" EXACT [EC:1.1.1.298] xref: EC:1.1.1.298 xref: KEGG_REACTION:R09289 xref: MetaCyc:RXN-8974 xref: RHEA:26438 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2010-05-05T10:55:07Z [Term] id: GO:0035528 name: UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin." [GOC:bf] synonym: "UDP-GlcNAc biosynthesis involved in chitin biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine formation involved in chitin biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis" EXACT [] is_a: GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process intersection_of: GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process intersection_of: part_of GO:0006031 ! chitin biosynthetic process relationship: part_of GO:0006031 ! chitin biosynthetic process created_by: rfoulger creation_date: 2010-05-05T04:49:49Z [Term] id: GO:0035529 name: NADH pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750] synonym: "NADH diphosphatase activity" EXACT [] synonym: "NADH pyrophosphohydrolase activity" EXACT [] xref: EC:3.6.1.9 xref: KEGG_REACTION:R00103 xref: MetaCyc:RXN0-4401 xref: Reactome:R-HSA-6809287 "NUDT12 hydrolyses NADH to NMNH" is_a: GO:0004551 ! nucleotide diphosphatase activity created_by: rfoulger creation_date: 2010-05-05T04:55:10Z [Term] id: GO:0035530 name: chemokine (C-C motif) ligand 6 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544] synonym: "CCL6 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: rfoulger creation_date: 2010-05-07T10:21:15Z [Term] id: GO:0035531 name: regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "regulation of CCL6 production" EXACT [] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production relationship: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production created_by: rfoulger creation_date: 2010-05-07T10:22:51Z [Term] id: GO:0035532 name: negative regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "negative regulation of CCL6 production" EXACT [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production relationship: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production created_by: rfoulger creation_date: 2010-05-07T10:23:40Z [Term] id: GO:0035533 name: positive regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "positive regulation of CCL6 production" EXACT [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production created_by: rfoulger creation_date: 2010-05-07T10:24:21Z [Term] id: GO:0035534 name: chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:amm] synonym: "CCL6 secretion" EXACT [] is_a: GO:0090195 ! chemokine secretion relationship: part_of GO:0035530 ! chemokine (C-C motif) ligand 6 production created_by: rfoulger creation_date: 2010-05-07T10:28:11Z [Term] id: GO:0035535 name: regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] synonym: "regulation of CCL6 secretion" EXACT [] is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0090196 ! regulation of chemokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion relationship: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion created_by: rfoulger creation_date: 2010-05-07T10:29:40Z [Term] id: GO:0035536 name: negative regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] synonym: "negative regulation of CCL6 secretion" EXACT [] is_a: GO:0035532 ! negative regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion is_a: GO:0090198 ! negative regulation of chemokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion relationship: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion created_by: rfoulger creation_date: 2010-05-07T10:30:14Z [Term] id: GO:0035537 name: positive regulation of chemokine (C-C motif) ligand 6 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] synonym: "positive regulation of CCL6 secretion" EXACT [] is_a: GO:0035533 ! positive regulation of chemokine (C-C motif) ligand 6 production is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion is_a: GO:0090197 ! positive regulation of chemokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion relationship: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion created_by: rfoulger creation_date: 2010-05-07T10:31:19Z [Term] id: GO:0035538 name: carbohydrate response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes." [GOC:BHF, PMID:20001964] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "ChoRE binding" EXACT [PMID:20001964] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: rfoulger creation_date: 2010-05-07T10:48:30Z [Term] id: GO:0035539 name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359] synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481] synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481] synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328] synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481] synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328] xref: Reactome:R-HSA-2395849 "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP" xref: Reactome:R-HSA-2395869 "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP" xref: RHEA:31575 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2010-05-07T10:54:19Z [Term] id: GO:0035540 name: positive regulation of SNARE complex disassembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035494 ! SNARE complex disassembly relationship: positively_regulates GO:0035494 ! SNARE complex disassembly created_by: rfoulger creation_date: 2010-05-10T01:42:21Z [Term] id: GO:0035541 name: negative regulation of SNARE complex disassembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0035495 ! regulation of SNARE complex disassembly is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035494 ! SNARE complex disassembly relationship: negatively_regulates GO:0035494 ! SNARE complex disassembly created_by: rfoulger creation_date: 2010-05-10T01:42:47Z [Term] id: GO:0035542 name: regulation of SNARE complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035493 ! SNARE complex assembly relationship: regulates GO:0035493 ! SNARE complex assembly created_by: rfoulger creation_date: 2010-05-10T01:49:35Z [Term] id: GO:0035543 name: positive regulation of SNARE complex assembly namespace: biological_process def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035493 ! SNARE complex assembly relationship: positively_regulates GO:0035493 ! SNARE complex assembly created_by: rfoulger creation_date: 2010-05-10T01:50:02Z [Term] id: GO:0035544 name: negative regulation of SNARE complex assembly namespace: biological_process def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0035542 ! regulation of SNARE complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035493 ! SNARE complex assembly relationship: negatively_regulates GO:0035493 ! SNARE complex assembly created_by: rfoulger creation_date: 2010-05-10T01:51:10Z [Term] id: GO:0035545 name: determination of left/right asymmetry in nervous system namespace: biological_process def: "The establishment of the nervous system with respect to the left and right halves." [GOC:kmv, PMID:17717195, PMID:19641012] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007399 ! nervous system development created_by: rfoulger creation_date: 2010-05-11T01:53:33Z [Term] id: GO:0035546 name: interferon-beta secretion namespace: biological_process def: "The regulated release of interferon-beta from a cell." [GOC:add, GOC:bf] synonym: "IFN-beta secretion" EXACT [] synonym: "IFNB secretion" EXACT [GOC:mah] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0032608 ! interferon-beta production created_by: rfoulger creation_date: 2010-05-12T10:04:11Z [Term] id: GO:0035547 name: regulation of interferon-beta secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "regulation of IFN-beta secretion" EXACT [] is_a: GO:0032648 ! regulation of interferon-beta production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035546 ! interferon-beta secretion relationship: regulates GO:0035546 ! interferon-beta secretion created_by: rfoulger creation_date: 2010-05-12T10:06:03Z [Term] id: GO:0035548 name: negative regulation of interferon-beta secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "down regulation of interferon-beta secretion" EXACT [] synonym: "down-regulation of interferon-beta secretion" EXACT [] synonym: "downregulation of interferon-beta secretion" EXACT [] synonym: "inhibition of interferon-beta secretion" NARROW [] synonym: "negative regulation of IFN-beta secretion" EXACT [] is_a: GO:0032688 ! negative regulation of interferon-beta production is_a: GO:0035547 ! regulation of interferon-beta secretion is_a: GO:0050710 ! negative regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035546 ! interferon-beta secretion relationship: negatively_regulates GO:0035546 ! interferon-beta secretion created_by: rfoulger creation_date: 2010-05-12T10:06:28Z [Term] id: GO:0035549 name: positive regulation of interferon-beta secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] synonym: "activation of interferon-beta secretion" NARROW [] synonym: "positive regulation of IFN-beta secretion" EXACT [] synonym: "stimulation of interferon-beta secretion" NARROW [] synonym: "up regulation of interferon-beta secretion" EXACT [] synonym: "up-regulation of interferon-beta secretion" EXACT [] synonym: "upregulation of interferon-beta secretion" EXACT [] is_a: GO:0032728 ! positive regulation of interferon-beta production is_a: GO:0035547 ! regulation of interferon-beta secretion is_a: GO:0050715 ! positive regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035546 ! interferon-beta secretion relationship: positively_regulates GO:0035546 ! interferon-beta secretion created_by: rfoulger creation_date: 2010-05-12T10:06:50Z [Term] id: GO:0035550 name: urease complex namespace: cellular_component def: "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide)." [InterPro:IPR008221, PMID:2651866] comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes. is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm created_by: rfoulger creation_date: 2010-05-12T01:00:27Z [Term] id: GO:0035551 name: protein initiator methionine removal involved in protein maturation namespace: biological_process def: "Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw] is_a: GO:0016485 ! protein processing is_a: GO:0070084 ! protein initiator methionine removal intersection_of: GO:0070084 ! protein initiator methionine removal intersection_of: part_of GO:0051604 ! protein maturation relationship: part_of GO:0051604 ! protein maturation created_by: rfoulger creation_date: 2010-05-13T04:29:05Z [Term] id: GO:0035552 name: oxidative single-stranded DNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698] synonym: "oxidative ssDNA demethylation" EXACT [] is_a: GO:0035511 ! oxidative DNA demethylation created_by: rfoulger creation_date: 2010-05-14T11:03:55Z [Term] id: GO:0035553 name: oxidative single-stranded RNA demethylation namespace: biological_process def: "Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698] synonym: "oxidative ssRNA demethylation" EXACT [] is_a: GO:0035513 ! oxidative RNA demethylation created_by: rfoulger creation_date: 2010-05-14T11:05:17Z [Term] id: GO:0035554 name: termination of Roundabout signal transduction namespace: biological_process def: "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated." [GOC:BHF, GOC:vk] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0035387 ! negative regulation of Roundabout signaling pathway relationship: part_of GO:0035385 ! Roundabout signaling pathway created_by: rfoulger creation_date: 2010-05-14T11:08:12Z [Term] id: GO:0035555 name: obsolete initiation of Roundabout signal transduction namespace: biological_process def: "OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO)." [GOC:vk] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "initiation of Roundabout signal transduction" EXACT [] is_obsolete: true consider: GO:0035385 consider: GO:0038023 consider: GO:0048495 created_by: rfoulger creation_date: 2010-05-14T11:10:20Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling] synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling chain" EXACT [ISBN:3527303782] synonym: "intracellular signaling pathway" RELATED [] synonym: "protein kinase cascade" NARROW [GOC:signaling] synonym: "signal transduction via intracellular signaling cascade" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular created_by: rfoulger creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035557 name: obsolete intracellular signal transduction involved in cell surface receptor linked signaling namespace: biological_process def: "OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782] comment: This term was made obsolete because the syntax of the term is incorrect. synonym: "intracellular signal transduction involved in cell surface receptor linked signaling" EXACT [] synonym: "intracellular signal transduction involved in cell surface receptor linked signalling" EXACT [GOC:mah] synonym: "intracellular signaling cascade involved in cell surface receptor linked signaling" EXACT [] synonym: "intracellular signaling chain involved in cell surface receptor signaling" EXACT [ISBN:3527303782] is_obsolete: true created_by: rfoulger creation_date: 2010-05-14T01:31:05Z [Term] id: GO:0035558 name: obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling namespace: biological_process def: "OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:signaling] comment: This term was made obsolete because the syntax of the term is incorrect. synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling" EXACT [] synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling" EXACT [] synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signaling" EXACT [] synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:mah] synonym: "PI3K cascade involved in signaling from the insulin receptor" EXACT [] is_obsolete: true consider: GO:0038028 created_by: rfoulger creation_date: 2010-05-14T01:34:38Z [Term] id: GO:0035559 name: obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling namespace: biological_process def: "OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling] comment: This term was made obsolete because the syntax of the term is incorrect. synonym: "MAPKKK cascade involved in epidermal growth factor receptor signaling" EXACT [] synonym: "MAPKKK cascade involved in epidermal growth factor receptor signalling" EXACT [GOC:mah] synonym: "MAPKKK cascade involved in signaling from the EGFR" EXACT [] is_obsolete: true consider: GO:0038029 created_by: rfoulger creation_date: 2010-05-14T01:53:15Z [Term] id: GO:0035560 name: pheophoridase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a." [EC:3.1.1.82, PMID:16228561] synonym: "phedase activity" EXACT [EC:3.1.1.82] synonym: "PPD activity" EXACT [EC:3.1.1.82] xref: EC:3.1.1.82 xref: RHEA:24784 is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: rfoulger creation_date: 2010-05-14T02:39:58Z [Term] id: GO:0035561 name: regulation of chromatin binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003682 ! chromatin binding relationship: regulates GO:0003682 ! chromatin binding created_by: rfoulger creation_date: 2010-05-19T10:28:36Z [Term] id: GO:0035562 name: negative regulation of chromatin binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] is_a: GO:0035561 ! regulation of chromatin binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003682 ! chromatin binding relationship: negatively_regulates GO:0003682 ! chromatin binding created_by: rfoulger creation_date: 2010-05-19T10:29:06Z [Term] id: GO:0035563 name: positive regulation of chromatin binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] is_a: GO:0035561 ! regulation of chromatin binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003682 ! chromatin binding relationship: positively_regulates GO:0003682 ! chromatin binding created_by: rfoulger creation_date: 2010-05-19T10:29:41Z [Term] id: GO:0035564 name: regulation of kidney size namespace: biological_process def: "Any process that modulates the size of a kidney." [GOC:bf] is_a: GO:0090066 ! regulation of anatomical structure size relationship: part_of GO:0060993 ! kidney morphogenesis created_by: rfoulger creation_date: 2010-07-23T11:28:22Z [Term] id: GO:0035565 name: regulation of pronephros size namespace: biological_process def: "Any process that modulates the size of a pronephric kidney." [GOC:bf] synonym: "regulation of pronephric kidney size" EXACT [GOC:bf] is_a: GO:0035564 ! regulation of kidney size relationship: part_of GO:0072114 ! pronephros morphogenesis created_by: rfoulger creation_date: 2010-07-23T11:28:57Z [Term] id: GO:0035566 name: regulation of metanephros size namespace: biological_process def: "Any process that modulates the size of a metanephric kidney." [GOC:bf] synonym: "regulation of metanephric kidney size" EXACT [GOC:bf] is_a: GO:0035564 ! regulation of kidney size relationship: part_of GO:0003338 ! metanephros morphogenesis created_by: rfoulger creation_date: 2010-07-23T11:34:06Z [Term] id: GO:0035567 name: non-canonical Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin." [GOC:signaling] comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term. synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway created_by: rfoulger creation_date: 2010-07-23T02:26:01Z [Term] id: GO:0035568 name: N-terminal peptidyl-proline methylation namespace: biological_process def: "The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419] xref: RESID:AA0419 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018208 ! peptidyl-proline modification created_by: rfoulger creation_date: 2010-08-06T01:52:43Z [Term] id: GO:0035569 name: obsolete N-terminal peptidyl-proline trimethylation namespace: biological_process def: "OBSOLETE. The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline." [PMID:20668449] comment: This term was made obsolete because N-terminal proline residues cannot be trimethylated. synonym: "N-terminal peptidyl-proline trimethylation" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2010-08-06T01:55:19Z [Term] id: GO:0035570 name: N-terminal peptidyl-serine methylation namespace: biological_process def: "The methylation of the N-terminal serine of proteins." [PMID:20668449] is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018209 ! peptidyl-serine modification created_by: rfoulger creation_date: 2010-08-06T01:58:11Z [Term] id: GO:0035571 name: N-terminal peptidyl-serine monomethylation namespace: biological_process def: "The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation created_by: rfoulger creation_date: 2010-08-06T01:58:56Z [Term] id: GO:0035572 name: N-terminal peptidyl-serine dimethylation namespace: biological_process def: "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation created_by: rfoulger creation_date: 2010-08-06T02:00:17Z [Term] id: GO:0035573 name: N-terminal peptidyl-serine trimethylation namespace: biological_process def: "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine." [PMID:20668449] is_a: GO:0035570 ! N-terminal peptidyl-serine methylation created_by: rfoulger creation_date: 2010-08-06T02:00:42Z [Term] id: GO:0035574 name: histone H4-K20 demethylation namespace: biological_process def: "The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone." [GOC:sp, PMID:20622853] is_a: GO:0070076 ! histone lysine demethylation created_by: rfoulger creation_date: 2010-08-13T10:50:06Z [Term] id: GO:0035575 name: histone demethylase activity (H4-K20 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein." [EC:1.14.11.27, PMID:20622853] xref: Reactome:R-HSA-2172678 "PHF8 demethylates histone H4K20me1" is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0035574 ! histone H4-K20 demethylation created_by: rfoulger creation_date: 2010-08-13T10:51:13Z [Term] id: GO:0035576 name: retinoic acid receptor signaling pathway involved in pronephric field specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop." [GOC:bf, PMID:16979153, PMID:19909807] synonym: "retinoic acid receptor signalling pathway involved in pronephric field specification" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0039003 ! pronephric field specification relationship: part_of GO:0039003 ! pronephric field specification created_by: rfoulger creation_date: 2010-10-05T01:19:35Z [Term] id: GO:0035577 name: azurophil granule membrane namespace: cellular_component def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule membrane" EXACT [] is_a: GO:0005765 ! lysosomal membrane is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042582 ! azurophil granule created_by: rfoulger creation_date: 2010-10-05T01:29:10Z [Term] id: GO:0035578 name: azurophil granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule lumen" EXACT [] is_a: GO:0005775 ! vacuolar lumen is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042582 ! azurophil granule created_by: rfoulger creation_date: 2010-10-05T01:30:33Z [Term] id: GO:0035579 name: specific granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] synonym: "secondary granule membrane" EXACT [] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042581 ! specific granule created_by: rfoulger creation_date: 2010-10-05T01:32:47Z [Term] id: GO:0035580 name: specific granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] synonym: "secondary granule lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042581 ! specific granule created_by: rfoulger creation_date: 2010-10-05T01:33:53Z [Term] id: GO:0035581 name: sequestering of extracellular ligand from receptor namespace: biological_process def: "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor." [GOC:BHF, GOC:signaling] comment: Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex. synonym: "extracellular sequestering of receptor ligand" EXACT [GOC:bf] synonym: "negative regulation of protein bioavailability" RELATED [GOC:BHF] is_a: GO:1900116 ! extracellular negative regulation of signal transduction created_by: rfoulger creation_date: 2010-10-12T03:12:11Z [Term] id: GO:0035582 name: sequestering of BMP in extracellular matrix namespace: biological_process def: "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins." [GOC:BHF, PMID:20855508] comment: Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex. synonym: "BMP sequestration in the ECM" EXACT [PMID:20855508] synonym: "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT [GOC:bf] synonym: "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT [GOC:mah] synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT [] is_a: GO:0030514 ! negative regulation of BMP signaling pathway is_a: GO:0035581 ! sequestering of extracellular ligand from receptor is_a: GO:0071694 ! maintenance of protein location in extracellular region created_by: rfoulger creation_date: 2010-10-12T03:12:45Z [Term] id: GO:0035583 name: sequestering of TGFbeta in extracellular matrix namespace: biological_process def: "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins." [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508] synonym: "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:bf] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:mah] synonym: "sequestering of TGFbeta large latency complex in extracellular matrix" EXACT [PMID:12482908] synonym: "sequestering of TGFbeta LLC in extracellular matrix" EXACT [PMID:12482908] is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0035581 ! sequestering of extracellular ligand from receptor is_a: GO:0071694 ! maintenance of protein location in extracellular region created_by: rfoulger creation_date: 2010-10-12T03:13:29Z [Term] id: GO:0035584 name: calcium-mediated signaling using intracellular calcium source namespace: biological_process def: "A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] synonym: "calcium signaling using intracellular calcium source" EXACT [] synonym: "calcium signalling using intracellular calcium source" EXACT [] synonym: "calcium-mediated signalling using intracellular calcium source" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling created_by: rfoulger creation_date: 2010-10-18T11:01:08Z [Term] id: GO:0035585 name: calcium-mediated signaling using extracellular calcium source namespace: biological_process def: "A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] synonym: "calcium signaling using extracellular calcium source" EXACT [] synonym: "calcium signalling using extracellular calcium source" EXACT [] synonym: "calcium-mediated signalling using extracellular calcium source" EXACT [] synonym: "extracellular calcium influx" NARROW [GOC:BHF] is_a: GO:0019722 ! calcium-mediated signaling created_by: rfoulger creation_date: 2010-10-18T11:04:27Z [Term] id: GO:0035586 name: purinergic receptor activity namespace: molecular_function def: "Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:bf, GOC:BHF, GOC:signaling, PMID:9755289] synonym: "purinoceptor" EXACT [PMID:9755289] synonym: "purinoreceptor" EXACT [PMID:9755289] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0035587 ! purinergic receptor signaling pathway created_by: rfoulger creation_date: 2010-10-22T10:57:12Z [Term] id: GO:0035587 name: purinergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "purinergic receptor signalling pathway" EXACT [GOC:mah] synonym: "purinoceptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2010-10-22T11:09:40Z [Term] id: GO:0035588 name: G protein-coupled purinergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "G-protein coupled purinergic receptor signaling pathway" EXACT [] synonym: "G-protein coupled purinergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0035587 ! purinergic receptor signaling pathway created_by: rfoulger creation_date: 2010-10-22T11:11:53Z [Term] id: GO:0035589 name: G protein-coupled purinergic nucleotide receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "G-protein coupled purinergic nucleotide receptor signaling pathway" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway created_by: rfoulger creation_date: 2010-10-22T11:18:59Z [Term] id: GO:0035590 name: purinergic nucleotide receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity." [GOC:BHF, PMID:9755289] synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0035587 ! purinergic receptor signaling pathway created_by: rfoulger creation_date: 2010-10-22T11:22:17Z [Term] id: GO:0035591 name: signaling adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf] comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. synonym: "signalling adaptor activity" EXACT [GOC:mah] is_a: GO:0030674 ! protein binding, bridging relationship: part_of GO:0009967 ! positive regulation of signal transduction created_by: rfoulger creation_date: 2010-11-05T11:22:01Z [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071692 ! protein localization to extracellular region created_by: rfoulger creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0035593 name: positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850] synonym: "positive regulation of Wnt diffusion" NARROW [PMID:19906850] synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region" EXACT [GOC:mah] synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region" EXACT [] synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:mah] synonym: "positive regulation of Wnt signaling range" RELATED [PMID:19906850] synonym: "positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0035592 ! establishment of protein localization to extracellular region created_by: rfoulger creation_date: 2010-11-09T10:29:44Z [Term] id: GO:0035594 name: ganglioside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues." [GOC:yaf] is_a: GO:0043208 ! glycosphingolipid binding is_a: GO:0097001 ! ceramide binding created_by: rfoulger creation_date: 2010-11-11T02:11:38Z [Term] id: GO:0035595 name: N-acetylglucosaminylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol." [EC:3.5.1.103, GOC:rs] synonym: "1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.103] synonym: "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity" EXACT [EC:3.5.1.103] synonym: "GlcNAc-Ins deacetylase activity" EXACT [GOC:rs] synonym: "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity" EXACT [EC:3.5.1.103] xref: EC:3.5.1.103 xref: KEGG_REACTION:R09651 xref: MetaCyc:RXN1G-2 xref: RHEA:26180 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity created_by: rfoulger creation_date: 2010-11-11T02:12:48Z [Term] id: GO:0035596 name: methylthiotransferase activity namespace: molecular_function def: "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor." [GOC:jh2, PMID:20472640] synonym: "MTTase" EXACT [PMID:20472640] is_a: GO:0050497 ! transferase activity, transferring alkylthio groups created_by: rfoulger creation_date: 2010-11-12T01:24:38Z [Term] id: GO:0035597 name: N6-isopentenyladenosine methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)." [PMID:20472640] synonym: "i6A methylthiotransferase activity" EXACT [PMID:20472640] is_a: GO:0035596 ! methylthiotransferase activity relationship: part_of GO:0035600 ! tRNA methylthiolation created_by: rfoulger creation_date: 2010-11-12T01:26:58Z [Term] id: GO:0035598 name: N6-threonylcarbomyladenosine methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)." [PMID:20472640, PMID:20584901] synonym: "t6A methylthiotransferase activity" EXACT [PMID:20472640] xref: Reactome:R-HSA-6786571 "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37" is_a: GO:0035596 ! methylthiotransferase activity relationship: part_of GO:0035600 ! tRNA methylthiolation created_by: rfoulger creation_date: 2010-11-12T01:28:32Z [Term] id: GO:0035599 name: aspartic acid methylthiotransferase activity namespace: molecular_function def: "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid." [PMID:18252828, PMID:8844851, RESID:AA0232] comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12. xref: RESID:AA0232 is_a: GO:0035596 ! methylthiotransferase activity relationship: part_of GO:0018339 ! peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid created_by: rfoulger creation_date: 2010-11-12T01:31:23Z [Term] id: GO:0035600 name: tRNA methylthiolation namespace: biological_process def: "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640] is_a: GO:0006400 ! tRNA modification created_by: rfoulger creation_date: 2010-11-12T01:34:02Z [Term] id: GO:0035601 name: protein deacylation namespace: biological_process def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] synonym: "protein amino acid deacylation" EXACT [GOC:se] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0098732 ! macromolecule deacylation created_by: rfoulger creation_date: 2010-11-15T11:06:15Z [Term] id: GO:0035602 name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mtg_apoptosis, GOC:yaf] synonym: "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" NARROW [] synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow cell relationship: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow cell created_by: rfoulger creation_date: 2010-11-15T11:09:20Z [Term] id: GO:0035603 name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in hematopoiesis" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in hematopoiesis" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signaling pathway involved in hematopoiesis" EXACT [GOC:yaf] synonym: "fibroblast growth factor receptor signalling pathway involved in hemopoiesis" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0030097 ! hemopoiesis relationship: part_of GO:0030097 ! hemopoiesis created_by: rfoulger creation_date: 2010-11-15T11:09:46Z [Term] id: GO:0035604 name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow relationship: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow created_by: rfoulger creation_date: 2010-11-15T11:10:14Z [Term] id: GO:0035605 name: peptidyl-cysteine S-nitrosylase activity namespace: molecular_function def: "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein." [EC:2.6.99.-, GOC:sp, PMID:20972425, PMID:20972426] comment: This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate. synonym: "protein nitrosylase activity" RELATED [GOC:sp] synonym: "S-nitrosylase activity" EXACT [PMID:20972426] is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0018119 ! peptidyl-cysteine S-nitrosylation created_by: rfoulger creation_date: 2010-11-16T09:49:26Z [Term] id: GO:0035606 name: peptidyl-cysteine S-trans-nitrosylation namespace: biological_process def: "Transfer of a nitric oxide (NO) group from one cysteine residue to another." [PMID:19854201, PMID:20972425, PMID:20972426] synonym: "cysteine to cysteine nitrosylation" EXACT [PMID:20972426] synonym: "cysteine-to-cysteine transnitrosylation" EXACT [PMID:20972426] synonym: "protein-to-protein transnitrosylation" BROAD [PMID:20972426] synonym: "S-transnitrosylation" EXACT [PMID:20972426] is_a: GO:0018119 ! peptidyl-cysteine S-nitrosylation created_by: rfoulger creation_date: 2010-11-16T09:54:46Z [Term] id: GO:0035607 name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state." [GOC:yaf] synonym: "FGF receptor signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] synonym: "FGFR signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0021769 ! orbitofrontal cortex development relationship: part_of GO:0021769 ! orbitofrontal cortex development created_by: rfoulger creation_date: 2010-11-16T11:30:19Z [Term] id: GO:0035608 name: protein deglutamylation namespace: biological_process def: "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048] synonym: "protein amino acid deglutamylation" EXACT [GOC:bf] is_a: GO:0018200 ! peptidyl-glutamic acid modification created_by: rfoulger creation_date: 2010-11-18T01:04:38Z [Term] id: GO:0035609 name: C-terminal protein deglutamylation namespace: biological_process def: "The removal of a C-terminal, gene-encoded glutamate residue from a protein." [GOC:sp, PMID:21074048] synonym: "protein primary sequence deglutamylation" EXACT [PMID:21074048] is_a: GO:0018410 ! C-terminal protein amino acid modification is_a: GO:0035608 ! protein deglutamylation created_by: rfoulger creation_date: 2010-11-18T01:06:00Z [Term] id: GO:0035610 name: protein side chain deglutamylation namespace: biological_process def: "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048] synonym: "removal of posttranslational polyglutamylation" EXACT [PMID:21074048] synonym: "shortening of glutamate side chain" RELATED [PMID:21074048] is_a: GO:0035608 ! protein deglutamylation created_by: rfoulger creation_date: 2010-11-18T01:09:03Z [Term] id: GO:0035611 name: protein branching point deglutamylation namespace: biological_process def: "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue." [GOC:sp, PMID:21074048] is_a: GO:0035608 ! protein deglutamylation created_by: rfoulger creation_date: 2010-11-18T01:11:21Z [Term] id: GO:0035612 name: AP-2 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499] synonym: "AP-2 clathrin adaptor complex binding" RELATED [GOC:bf] is_a: GO:0044877 ! protein-containing complex binding created_by: rfoulger creation_date: 2010-11-25T03:51:17Z [Term] id: GO:0035613 name: RNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] synonym: "RNA hairpin binding" EXACT [PMID:16568238] synonym: "RNA hairpin loop binding" EXACT [PMID:16568238] is_a: GO:0003723 ! RNA binding created_by: rfoulger creation_date: 2010-11-26T10:41:49Z [Term] id: GO:0035614 name: snRNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] synonym: "small nuclear RNA stem-loop binding" EXACT [] synonym: "snRNA hairpin binding" EXACT [PMID:16568238] synonym: "snRNA hairpin loop binding" EXACT [PMID:16568238] is_a: GO:0017069 ! snRNA binding is_a: GO:0035613 ! RNA stem-loop binding created_by: rfoulger creation_date: 2010-11-26T10:43:17Z [Term] id: GO:0035615 name: clathrin adaptor activity namespace: molecular_function def: "Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179] synonym: "clathrin-associated adaptor activity" EXACT [PMID:15728179] is_a: GO:0030276 ! clathrin binding is_a: GO:0140312 ! cargo adaptor activity created_by: rfoulger creation_date: 2010-12-01T11:17:57Z [Term] id: GO:0035616 name: histone H2B conserved C-terminal lysine deubiquitination namespace: biological_process def: "A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442] synonym: "budding yeast H2B K123 deubiquitination" NARROW [GOC:vw] synonym: "fission yeast H2B K119 deubiquitination" NARROW [GOC:vw] synonym: "mammalian H2B K120 deubiquitination" NARROW [GOC:vw] is_a: GO:0016578 ! histone deubiquitination created_by: rfoulger creation_date: 2010-12-03T10:36:44Z [Term] id: GO:0035617 name: stress granule disassembly namespace: biological_process def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938] synonym: "SG disassembly" EXACT [PMID:19825938] is_a: GO:0032988 ! ribonucleoprotein complex disassembly is_a: GO:1903008 ! organelle disassembly created_by: rfoulger creation_date: 2010-12-03T10:38:57Z [Term] id: GO:0035618 name: root hair namespace: cellular_component def: "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall." [http://www.jstor.org/stable/4354264, PO:0000256] comment: This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct. is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: rfoulger creation_date: 2010-12-03T01:42:40Z [Term] id: GO:0035619 name: root hair tip namespace: cellular_component def: "The tip portion of an outgrowth of a root epidermal cell." [PMID:16567499] synonym: "root hair cell tip" EXACT [] is_a: GO:0051286 ! cell tip intersection_of: GO:0051286 ! cell tip intersection_of: part_of GO:0035618 ! root hair relationship: part_of GO:0035618 ! root hair created_by: rfoulger creation_date: 2010-12-03T01:43:55Z [Term] id: GO:0035621 name: ER to Golgi ceramide transport namespace: biological_process def: "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229] synonym: "endoplasmic reticulum to Golgi ceramide transport" EXACT [GOC:bf] synonym: "ER to Golgi ceramide translocation" EXACT [PMID:14685229] synonym: "non-vesicular ceramide trafficking" EXACT [PMID:14685229] is_a: GO:0032365 ! intracellular lipid transport is_a: GO:0035627 ! ceramide transport created_by: rfoulger creation_date: 2010-12-08T12:36:35Z [Term] id: GO:0035622 name: intrahepatic bile duct development namespace: biological_process def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] synonym: "IHBD development" EXACT [PMID:20614624] synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] is_a: GO:0061009 ! common bile duct development relationship: part_of GO:0001889 ! liver development created_by: rfoulger creation_date: 2010-12-08T04:10:50Z [Term] id: GO:0035623 name: renal glucose absorption namespace: biological_process def: "A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf, PMID:11269503] synonym: "glucose reabsorption" EXACT [GOC:yaf] synonym: "nephron glucose absorption" EXACT [GOC:yaf] is_a: GO:0070293 ! renal absorption is_a: GO:1904659 ! glucose transmembrane transport created_by: rfoulger creation_date: 2010-12-08T04:14:23Z [Term] id: GO:0035624 name: receptor transactivation namespace: biological_process def: "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer." [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387] is_a: GO:2000273 ! positive regulation of signaling receptor activity created_by: rfoulger creation_date: 2010-12-08T04:18:18Z [Term] id: GO:0035625 name: obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway namespace: biological_process def: "OBSOLETE. The process in which an epidermal growth factor-activated receptor is activated via signaling events from a consequence of a G protein-coupled . This is an example of cross-talk between the EGF and GPCR signaling pathways." [GOC:bf, GOC:BHF, PMID:10622253, PMID:17655843] comment: This term was obsoleted because it should be captured as a GO-CAM model, see https://github.com/geneontology/go-ontology/issues/15823. synonym: "EGFR transactivation by GPCR" EXACT [GOC:bf] synonym: "EGFR transactivation upon GPCR stimulation" EXACT [PMID:10622253] synonym: "epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway" EXACT [GOC:bf, GOC:signaling] synonym: "epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signalling pathway" EXACT [GOC:mah] is_obsolete: true created_by: rfoulger creation_date: 2010-12-08T04:19:12Z [Term] id: GO:0035626 name: juvenile hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] synonym: "juvenile hormone mediated signalling pathway" EXACT [GOC:bf] synonym: "juvenile hormone-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway created_by: rfoulger creation_date: 2010-12-08T04:45:25Z [Term] id: GO:0035627 name: ceramide transport namespace: biological_process def: "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart] is_a: GO:0006869 ! lipid transport is_a: GO:0042886 ! amide transport created_by: rfoulger creation_date: 2010-12-10T10:02:16Z [Term] id: GO:0035628 name: cystic duct development namespace: biological_process def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct." [PMID:20614624] is_a: GO:0061009 ! common bile duct development created_by: rfoulger creation_date: 2010-12-10T01:24:28Z [Term] id: GO:0035629 name: N-terminal protein amino acid N-linked glycosylation namespace: biological_process def: "Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein." [GOC:bf, GOC:pr] comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0031365 ! N-terminal protein amino acid modification created_by: rfoulger creation_date: 2010-12-17T10:45:48Z [Term] id: GO:0035630 name: bone mineralization involved in bone maturation namespace: biological_process def: "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF] comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'. is_a: GO:0030282 ! bone mineralization intersection_of: GO:0030282 ! bone mineralization intersection_of: part_of GO:0043931 ! ossification involved in bone maturation relationship: part_of GO:0043931 ! ossification involved in bone maturation created_by: rfoulger creation_date: 2010-12-20T01:57:31Z [Term] id: GO:0035631 name: CD40 receptor complex namespace: cellular_component def: "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: rfoulger creation_date: 2010-12-21T10:35:05Z [Term] id: GO:0035632 name: mitochondrial prohibitin complex namespace: cellular_component def: "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222] synonym: "mitochondrial inner membrane prohibitin complex" EXACT [GOC:bf] is_a: GO:0098800 ! inner mitochondrial membrane protein complex created_by: rfoulger creation_date: 2010-12-21T10:38:59Z [Term] id: GO:0035633 name: maintenance of permeability of blood-brain barrier namespace: biological_process def: "Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:bf, GOC:sl, PMID:20080302] synonym: "maintenance of BBB" RELATED [PMID:20080302] synonym: "maintenance of blood-brain barrier" RELATED [] is_a: GO:0065008 ! regulation of biological quality created_by: rfoulger creation_date: 2011-01-07T10:33:11Z [Term] id: GO:0035634 name: response to stilbenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [GOC:yaf, Wikipedia:Stilbenoid] subset: goslim_chembl is_a: GO:0014070 ! response to organic cyclic compound created_by: rfoulger creation_date: 2011-01-12T10:37:33Z [Term] id: GO:0035635 name: entry of bacterium into host cell namespace: biological_process def: "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:21187937] synonym: "bacterial entry into host cell" EXACT [GOC:bf] synonym: "invasion of bacteria into host cell" EXACT [GOC:bf] is_a: GO:0030260 ! entry into host cell created_by: rfoulger creation_date: 2011-01-13T02:26:54Z [Term] id: GO:0035636 name: obsolete multi-organism signaling namespace: biological_process def: "OBSOLETE. The transfer of information between living organisms." [GOC:go_curators] comment: This term was obsoleted because it was a grouping term but had no subclasses. synonym: "multi-organism signalling" EXACT [GOC:bf] synonym: "pheromone signaling" NARROW [GOC:bf] synonym: "signaling between organisms" EXACT [GOC:bf] synonym: "signaling with other organism" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2011-01-14T10:11:25Z [Term] id: GO:0035637 name: multicellular organismal signaling namespace: biological_process def: "The transfer of information occurring at the level of a multicellular organism." [GOC:go_curators] synonym: "multicellular organismal signalling" EXACT [GOC:bf] is_a: GO:0023052 ! signaling is_a: GO:0032501 ! multicellular organismal process created_by: rfoulger creation_date: 2011-01-14T10:13:50Z [Term] id: GO:0035638 name: signal maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a signal. A signal is a physical entity or change in state that is used to transfer information to trigger a response, and is functional when it can activate a receptor." [GOC:bf, GOC:pde, GOC:signaling] synonym: "ligand maturation" NARROW [GOC:bf] is_a: GO:0009987 ! cellular process relationship: part_of GO:0023056 ! positive regulation of signaling created_by: rfoulger creation_date: 2011-01-14T10:38:33Z [Term] id: GO:0035639 name: purine ribonucleoside triphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] synonym: "purine NTP binding" BROAD [GOC:ebc] is_a: GO:0043168 ! anion binding is_a: GO:1901265 ! nucleoside phosphate binding created_by: rfoulger creation_date: 2011-01-14T02:46:42Z [Term] id: GO:0035640 name: exploration behavior namespace: biological_process def: "The specific behavior of an organism in response to a novel environment or stimulus." [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169] comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641. synonym: "exploration behaviour" EXACT [GOC:bf] synonym: "exploratory behavior" EXACT [PMID:20869398] synonym: "exploratory behaviour" EXACT [PMID:11682103] synonym: "open-field behavior" NARROW [PMID:11682103] is_a: GO:0007610 ! behavior created_by: rfoulger creation_date: 2011-01-19T10:35:45Z [Term] id: GO:0035641 name: locomotory exploration behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232] is_a: GO:0007626 ! locomotory behavior is_a: GO:0035640 ! exploration behavior created_by: rfoulger creation_date: 2011-01-19T10:40:04Z [Term] id: GO:0035642 name: histone methyltransferase activity (H3-R17 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3." [GOC:sp, PMID:11341840] synonym: "histone methylase activity (H3-R17 specific)" EXACT [GOC:bf] synonym: "histone-arginine N-methyltransferase activity (H3-R17 specific)" EXACT [GOC:bf] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity relationship: part_of GO:0034971 ! histone H3-R17 methylation created_by: rfoulger creation_date: 2011-01-19T10:41:43Z [Term] id: GO:0035643 name: L-DOPA receptor activity namespace: molecular_function def: "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine." [PMID:18828673, Wikipedia:L-DOPA] synonym: "L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity" EXACT [] synonym: "L-dopa receptor activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity relationship: has_part GO:0072544 ! L-DOPA binding created_by: rfoulger creation_date: 2011-01-20T10:34:23Z [Term] id: GO:0035644 name: phosphoanandamide dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a phosphorylated anandamide." [GOC:BHF, PMID:16938887] is_a: GO:0016311 ! dephosphorylation created_by: rfoulger creation_date: 2011-01-21T02:14:04Z [Term] id: GO:0035645 name: enteric smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0048565 ! digestive tract development created_by: rfoulger creation_date: 2011-01-21T02:58:58Z [Term] id: GO:0035646 name: endosome to melanosome transport namespace: biological_process def: "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle." [PMID:16162817] is_a: GO:0043485 ! endosome to pigment granule transport created_by: rfoulger creation_date: 2011-01-24T01:30:07Z [Term] id: GO:0035647 name: 3-oxo-delta(4,5)-steroid 5-beta-reductase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+)." [GOC:kad, MetaCyc:RXN-9726, PMID:19166903] synonym: "3-oxo-delta4,5-steroid 5beta-reductase" EXACT [GOC:kad] is_a: GO:0035671 ! enone reductase activity created_by: rfoulger creation_date: 2011-01-24T01:31:30Z [Term] id: GO:0035648 name: circadian mating behavior namespace: biological_process def: "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle." [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917] synonym: "circadian mating behaviour" EXACT [GOC:bf] synonym: "circadian mating rhythm" EXACT [GOC:dos] is_a: GO:0007617 ! mating behavior is_a: GO:0048512 ! circadian behavior created_by: rfoulger creation_date: 2011-01-25T10:20:05Z [Term] id: GO:0035649 name: Nrd1 complex namespace: cellular_component def: "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p." [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2011-01-25T10:23:25Z [Term] id: GO:0035650 name: AP-1 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [PMID:21097499] is_a: GO:0044877 ! protein-containing complex binding created_by: rfoulger creation_date: 2011-01-25T10:58:52Z [Term] id: GO:0035651 name: AP-3 adaptor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [PMID:21097499] is_a: GO:0044877 ! protein-containing complex binding created_by: rfoulger creation_date: 2011-01-25T10:59:36Z [Term] id: GO:0035652 name: clathrin-coated vesicle cargo loading namespace: biological_process def: "Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:lb, PMID:16162817] synonym: "cargo loading into clathrin-coated vesicle" EXACT [] is_a: GO:0035459 ! vesicle cargo loading created_by: rfoulger creation_date: 2011-01-25T11:00:43Z [Term] id: GO:0035653 name: clathrin-coated vesicle cargo loading, AP-1-mediated namespace: biological_process def: "Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking." [GOC:lb, PMID:12802059, PMID:16162817] synonym: "cargo loading into clathrin-coated vesicle, AP-1-mediated" EXACT [] is_a: GO:0035652 ! clathrin-coated vesicle cargo loading created_by: rfoulger creation_date: 2011-01-25T11:01:38Z [Term] id: GO:0035654 name: clathrin-coated vesicle cargo loading, AP-3-mediated namespace: biological_process def: "Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle." [GOC:lb, PMID:12802059, PMID:16162817] synonym: "cargo loading into clathrin-coated vesicle, AP-3-mediated" EXACT [] is_a: GO:0035652 ! clathrin-coated vesicle cargo loading created_by: rfoulger creation_date: 2011-01-25T11:02:30Z [Term] id: GO:0035655 name: interleukin-18-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:signaling] synonym: "interleukin-18-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071351 ! cellular response to interleukin-18 created_by: rfoulger creation_date: 2011-01-26T09:55:57Z [Term] id: GO:0035656 name: kinesin-associated melanosomal adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes." [PMID:19841138] synonym: "kinesin-melanosome adaptor activity" EXACT [GOC:bf] is_a: GO:0019894 ! kinesin binding is_a: GO:0030674 ! protein binding, bridging created_by: rfoulger creation_date: 2011-01-27T01:32:51Z [Term] id: GO:0035657 name: eRF1 methyltransferase complex namespace: cellular_component def: "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505] synonym: "eRF1 MTase complex" EXACT [PMID:17008308] is_a: GO:0034708 ! methyltransferase complex created_by: rfoulger creation_date: 2011-01-28T11:29:40Z [Term] id: GO:0035658 name: Mon1-Ccz1 complex namespace: cellular_component def: "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005770 ! late endosome created_by: rfoulger creation_date: 2011-01-28T11:31:20Z [Term] id: GO:0035659 name: Wnt signaling pathway involved in wound healing, spreading of epidermal cells namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:BHF] synonym: "Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [] synonym: "Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0035313 ! wound healing, spreading of epidermal cells relationship: part_of GO:0035313 ! wound healing, spreading of epidermal cells created_by: rfoulger creation_date: 2011-01-28T11:34:02Z [Term] id: GO:0035660 name: MyD88-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834, PMID:20385024] synonym: "MyD88-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "MyD88-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway is_a: GO:0034142 ! toll-like receptor 4 signaling pathway created_by: rfoulger creation_date: 2011-02-01T10:10:04Z [Term] id: GO:0035661 name: MyD88-dependent toll-like receptor 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response." [GOC:BHF, PMID:20385024] synonym: "MyD88-dependent TLR2 signaling pathway" EXACT [GOC:bf] synonym: "MyD88-dependent toll-like receptor 2 signalling pathway" EXACT [GOC:bf] is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway is_a: GO:0034134 ! toll-like receptor 2 signaling pathway created_by: rfoulger creation_date: 2011-02-01T10:11:01Z [Term] id: GO:0035662 name: Toll-like receptor 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834] synonym: "TLR4 binding" EXACT [GOC:bf] is_a: GO:0035325 ! Toll-like receptor binding created_by: rfoulger creation_date: 2011-02-01T10:20:59Z [Term] id: GO:0035663 name: Toll-like receptor 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." [GOC:BHF] synonym: "TLR2 binding" EXACT [GOC:bf] is_a: GO:0035325 ! Toll-like receptor binding created_by: rfoulger creation_date: 2011-02-01T10:21:51Z [Term] id: GO:0035664 name: TIRAP-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442] synonym: "MAL-dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] synonym: "MyD88 adapter-like dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] synonym: "TIRAP-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TIRAP-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002224 ! toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:31:37Z [Term] id: GO:0035665 name: TIRAP-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:12447441] synonym: "MAL-dependent toll-like receptor 4 signaling pathway" EXACT [PMID:11544529] synonym: "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway" EXACT [GOC:11544529] synonym: "TIRAP-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TIRAP-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035664 ! TIRAP-dependent toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:33:48Z [Term] id: GO:0035666 name: TRIF-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:12855817] synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway" EXACT [PMID:12855817] synonym: "TRIF-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TRIF-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:35:35Z [Term] id: GO:0035667 name: TRIF-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18641322, PMID:20511708] synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway" EXACT [PMID:12855817] synonym: "TRIF-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TRIF-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035666 ! TRIF-dependent toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:37:25Z [Term] id: GO:0035668 name: TRAM-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:14556004] synonym: "TRAM-dependent TLR signaling pathway" EXACT [GOC:bf] synonym: "TRAM-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:39:34Z [Term] id: GO:0035669 name: TRAM-dependent toll-like receptor 4 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:14556004, PMID:18297073] synonym: "TRAM-dependent TLR4 signaling pathway" EXACT [GOC:bf] synonym: "TRAM-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] is_a: GO:0034142 ! toll-like receptor 4 signaling pathway is_a: GO:0035668 ! TRAM-dependent toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-01T02:41:09Z [Term] id: GO:0035670 name: plant-type ovary development namespace: biological_process def: "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed." [GOC:bf, GOC:tb, ISBN:0879015322] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0048440 ! carpel development created_by: rfoulger creation_date: 2011-02-04T09:35:05Z [Term] id: GO:0035671 name: enone reductase activity namespace: molecular_function def: "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+." [EC:1.3.1.-, GOC:kad, PMID:17945329, PMID:19166903] xref: MetaCyc:RXN-12267 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2011-02-04T10:59:15Z [Term] id: GO:0035672 name: oligopeptide transmembrane transport namespace: biological_process def: "The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "oligopeptide membrane transport" EXACT [] is_a: GO:0006857 ! oligopeptide transport is_a: GO:0055085 ! transmembrane transport created_by: rfoulger creation_date: 2011-02-08T02:18:07Z [Term] id: GO:0035673 name: oligopeptide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015198 def: "Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732] synonym: "oligopeptide transporter activity" RELATED [] is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0035672 ! oligopeptide transmembrane transport created_by: rfoulger creation_date: 2011-02-08T02:20:14Z [Term] id: GO:0035674 name: tricarboxylic acid transmembrane transport namespace: biological_process def: "The process in which a tricarboxylic acid is transported across a membrane." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "tricarboxylic acid membrane transport" EXACT [] is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: rfoulger creation_date: 2011-02-08T02:37:31Z [Term] id: GO:0035675 name: neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856] is_a: GO:0048666 ! neuron development relationship: part_of GO:0048886 ! neuromast hair cell differentiation created_by: rfoulger creation_date: 2011-02-14T11:01:42Z [Term] id: GO:0035676 name: anterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0035675 ! neuromast hair cell development relationship: part_of GO:0048903 ! anterior lateral line neuromast hair cell differentiation created_by: rfoulger creation_date: 2011-02-14T11:03:57Z [Term] id: GO:0035677 name: posterior lateral line neuromast hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509] is_a: GO:0035675 ! neuromast hair cell development relationship: part_of GO:0048923 ! posterior lateral line neuromast hair cell differentiation created_by: rfoulger creation_date: 2011-02-14T11:04:57Z [Term] id: GO:0035678 name: neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0035675 ! neuromast hair cell development created_by: rfoulger creation_date: 2011-02-14T11:06:15Z [Term] id: GO:0035679 name: anterior lateral line neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0035678 ! neuromast hair cell morphogenesis relationship: part_of GO:0035676 ! anterior lateral line neuromast hair cell development created_by: rfoulger creation_date: 2011-02-14T11:06:54Z [Term] id: GO:0035680 name: posterior lateral line neuromast hair cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509] is_a: GO:0035678 ! neuromast hair cell morphogenesis relationship: part_of GO:0035677 ! posterior lateral line neuromast hair cell development created_by: rfoulger creation_date: 2011-02-14T11:08:14Z [Term] id: GO:0035681 name: toll-like receptor 15 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 15." [GOC:pde] synonym: "TLR15 signaling pathway" EXACT [GOC:bf] synonym: "toll-like receptor 15 signalling pathway" EXACT [GOC:mah] is_a: GO:0002224 ! toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-21T02:38:47Z [Term] id: GO:0035682 name: toll-like receptor 21 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 21." [GOC:pde] synonym: "TLR21 signaling pathway" EXACT [GOC:bf] synonym: "toll-like receptor 21 signalling pathway" EXACT [GOC:mah] is_a: GO:0002224 ! toll-like receptor signaling pathway created_by: rfoulger creation_date: 2011-02-21T02:39:39Z [Term] id: GO:0035683 name: memory T cell extravasation namespace: biological_process def: "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [CL:0000813, GOC:BHF] synonym: "memory T-cell extravasation" EXACT [GOC:ebc] is_a: GO:0072683 ! T cell extravasation created_by: rfoulger creation_date: 2011-02-23T01:10:02Z [Term] id: GO:0035684 name: helper T cell extravasation namespace: biological_process def: "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells." [CL:0000912, GOC:BHF] synonym: "helper T-cell extravasation" EXACT [GOC:ebc] synonym: "T-helper cell extravasation" EXACT [CL:0000912] is_a: GO:0072683 ! T cell extravasation created_by: rfoulger creation_date: 2011-02-23T01:11:05Z [Term] id: GO:0035685 name: helper T cell diapedesis namespace: biological_process def: "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [CL:0000912, GOC:BHF] synonym: "helper T-cell diapedesis" EXACT [CL:0000912] synonym: "T-helper cell diapedesis" EXACT [CL:0000912] is_a: GO:0050904 ! diapedesis is_a: GO:0072678 ! T cell migration relationship: part_of GO:0035684 ! helper T cell extravasation created_by: rfoulger creation_date: 2011-02-23T01:11:52Z [Term] id: GO:0035686 name: sperm fibrous sheath namespace: cellular_component def: "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat." [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552] synonym: "flagellar fibrous sheath" EXACT [] synonym: "flagellum fibrous sheath" EXACT [GOC:bf] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: rfoulger creation_date: 2011-02-24T09:10:58Z [Term] id: GO:0035687 name: T-helper 1 cell extravasation namespace: biological_process def: "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF] synonym: "Th1 cell extravasation" EXACT [CL:0000545] is_a: GO:0035684 ! helper T cell extravasation is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-02-24T10:10:00Z [Term] id: GO:0035688 name: T-helper 1 cell diapedesis namespace: biological_process def: "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF, PMID:10477596] synonym: "Th1 cell diapedesis" EXACT [CL:0000545] is_a: GO:0035685 ! helper T cell diapedesis relationship: part_of GO:0035687 ! T-helper 1 cell extravasation created_by: rfoulger creation_date: 2011-02-24T10:12:11Z [Term] id: GO:0035689 name: chemokine (C-C motif) ligand 5 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:18337562] synonym: "CCL5-mediated signaling pathway" EXACT [PMID:18337562] synonym: "chemokine (C-C motif) ligand 5 signalling pathway" EXACT [GOC:mah] synonym: "RANTES-mediated signaling pathway" EXACT [PMID:19122644] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2011-02-24T12:56:13Z [Term] id: GO:0035690 name: cellular response to drug namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:sl] subset: goslim_chembl is_a: GO:0042493 ! response to drug is_a: GO:0070887 ! cellular response to chemical stimulus created_by: rfoulger creation_date: 2011-02-24T03:37:26Z [Term] id: GO:0035691 name: macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:12782713, PMID:19413900] synonym: "macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] synonym: "MIF signaling pathway" EXACT [GOC:ebc] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2011-02-25T11:31:21Z [Term] id: GO:0035692 name: macrophage migration inhibitory factor receptor complex namespace: cellular_component def: "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins." [GOC:BHF, PMID:12782713, PMID:17045821] is_a: GO:0043235 ! receptor complex created_by: rfoulger creation_date: 2011-02-25T11:33:15Z [Term] id: GO:0035693 name: NOS2-CD74 complex namespace: cellular_component def: "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases." [GOC:BHF, PMID:18003616] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2011-02-25T11:35:38Z [Term] id: GO:0035694 name: mitochondrial protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228] synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf] synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf] is_a: GO:0044257 ! cellular protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0007005 ! mitochondrion organization created_by: rfoulger creation_date: 2011-02-28T11:06:40Z [Term] id: GO:0035695 name: mitophagy by induced vacuole formation namespace: biological_process def: "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228] comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome. synonym: "MIV-mediated mitophagy" NARROW [PMID:21264228] is_a: GO:0000422 ! autophagy of mitochondrion created_by: rfoulger creation_date: 2011-02-28T03:01:04Z [Term] id: GO:0035696 name: monocyte extravasation namespace: biological_process def: "The migration of a monocyte from the blood vessels into the surrounding tissue." [CL:0000576, GOC:BHF, PMID:10657654] is_a: GO:0045123 ! cellular extravasation is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration created_by: rfoulger creation_date: 2011-02-28T03:05:52Z [Term] id: GO:0035697 name: CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue." [CL:0000625, GOC:BHF] is_a: GO:0072683 ! T cell extravasation created_by: rfoulger creation_date: 2011-02-28T03:08:49Z [Term] id: GO:0035698 name: CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue." [CL:0000794, GOC:BHF] is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-02-28T03:09:53Z [Term] id: GO:0035699 name: T-helper 17 cell extravasation namespace: biological_process def: "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue." [CL:0000899, GOC:BHF] is_a: GO:0035684 ! helper T cell extravasation is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-02-28T03:13:27Z [Term] id: GO:0035700 name: astrocyte chemotaxis namespace: biological_process def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471] is_a: GO:0043615 ! astrocyte cell migration is_a: GO:0060326 ! cell chemotaxis created_by: rfoulger creation_date: 2011-02-28T03:17:52Z [Term] id: GO:0035701 name: hematopoietic stem cell migration namespace: biological_process def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092] synonym: "hemopoietic stem cell migration" EXACT [CL:0000037] is_a: GO:0016477 ! cell migration created_by: rfoulger creation_date: 2011-02-28T03:20:36Z [Term] id: GO:0035702 name: monocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis created_by: rfoulger creation_date: 2011-03-02T11:32:57Z [Term] id: GO:0035703 name: monocyte migration into blood stream namespace: biological_process def: "The movement of a monocyte from the bone marrow to the blood stream." [CL:0000576, GOC:BHF] synonym: "release of monocytes into circulation" EXACT [GOC:bf] is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration relationship: part_of GO:0008015 ! blood circulation created_by: rfoulger creation_date: 2011-03-02T11:37:54Z [Term] id: GO:0035704 name: helper T cell chemotaxis namespace: biological_process def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF] synonym: "T-helper cell chemotaxis" EXACT [CL:0000912] is_a: GO:0010818 ! T cell chemotaxis created_by: rfoulger creation_date: 2011-03-02T02:31:48Z [Term] id: GO:0035705 name: T-helper 17 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF] synonym: "Th17 cell chemotaxis" EXACT [CL:0000899] is_a: GO:0035704 ! helper T cell chemotaxis created_by: rfoulger creation_date: 2011-03-02T02:35:16Z [Term] id: GO:0035706 name: T-helper 1 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF] synonym: "Th1 cell chemotaxis" EXACT [CL:0000545] is_a: GO:0035704 ! helper T cell chemotaxis created_by: rfoulger creation_date: 2011-03-02T02:36:49Z [Term] id: GO:0035707 name: T-helper 2 cell chemotaxis namespace: biological_process def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF] synonym: "Th2 cell chemotaxis" EXACT [CL:0000546] is_a: GO:0035704 ! helper T cell chemotaxis created_by: rfoulger creation_date: 2011-03-02T02:37:44Z [Term] id: GO:0035708 name: interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4)." [GOC:BHF, PMID:12496423] synonym: "IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:add, GOC:bf] is_a: GO:0048289 ! isotype switching to IgE isotypes created_by: rfoulger creation_date: 2011-03-02T02:40:35Z [Term] id: GO:0035709 name: memory T cell activation namespace: biological_process def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF] is_a: GO:0042110 ! T cell activation created_by: rfoulger creation_date: 2011-03-02T03:03:02Z [Term] id: GO:0035710 name: CD4-positive, alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF] is_a: GO:0046631 ! alpha-beta T cell activation created_by: rfoulger creation_date: 2011-03-02T03:04:11Z [Term] id: GO:0035711 name: T-helper 1 cell activation namespace: biological_process def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF] synonym: "Th1 cell activation" EXACT [CL:0000545] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation created_by: rfoulger creation_date: 2011-03-02T03:05:08Z [Term] id: GO:0035712 name: T-helper 2 cell activation namespace: biological_process def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF] synonym: "Th2 cell activation" EXACT [CL:0000546] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation created_by: rfoulger creation_date: 2011-03-02T03:05:59Z [Term] id: GO:0035713 name: response to nitrogen dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF] synonym: "response to NO2" EXACT [] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2011-03-02T03:14:51Z [Term] id: GO:0035714 name: cellular response to nitrogen dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF] synonym: "cellular response to NO2" EXACT [] is_a: GO:0035713 ! response to nitrogen dioxide is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: rfoulger creation_date: 2011-03-02T03:16:37Z [Term] id: GO:0035715 name: chemokine (C-C motif) ligand 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 2." [GOC:BHF] synonym: "CCL2 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding created_by: rfoulger creation_date: 2011-03-03T04:24:24Z [Term] id: GO:0035716 name: chemokine (C-C motif) ligand 12 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 12." [GOC:BHF] synonym: "CCL12 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding created_by: rfoulger creation_date: 2011-03-03T04:25:01Z [Term] id: GO:0035717 name: chemokine (C-C motif) ligand 7 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7." [GOC:BHF] synonym: "CCL7 binding" EXACT [GOC:ebc] is_a: GO:0019957 ! C-C chemokine binding created_by: rfoulger creation_date: 2011-03-03T04:25:41Z [Term] id: GO:0035718 name: macrophage migration inhibitory factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor." [GOC:BHF, PMID:19601712] synonym: "MIF binding" EXACT [PMID:19601712] is_a: GO:0019955 ! cytokine binding created_by: rfoulger creation_date: 2011-03-03T04:27:16Z [Term] id: GO:0035719 name: tRNA import into nucleus namespace: biological_process def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305] synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305] synonym: "tRNA nuclear import" EXACT [GOC:vw] is_a: GO:0006404 ! RNA import into nucleus is_a: GO:0051031 ! tRNA transport created_by: rfoulger creation_date: 2011-03-03T04:32:35Z [Term] id: GO:0035720 name: intraciliary anterograde transport namespace: biological_process def: "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins." [GOC:BHF, GOC:cilia, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "intraflagellar anterograde transport" EXACT [] is_a: GO:0042073 ! intraciliary transport created_by: rfoulger creation_date: 2011-03-07T11:24:53Z [Term] id: GO:0035721 name: intraciliary retrograde transport namespace: biological_process def: "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "intraflagellar retrograde transport" EXACT [] is_a: GO:0042073 ! intraciliary transport created_by: rfoulger creation_date: 2011-03-07T11:25:32Z [Term] id: GO:0035722 name: interleukin-12-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] synonym: "IL-12-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-12-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071349 ! cellular response to interleukin-12 created_by: rfoulger creation_date: 2011-03-07T11:27:58Z [Term] id: GO:0035723 name: interleukin-15-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] synonym: "IL-15-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-15-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071350 ! cellular response to interleukin-15 created_by: rfoulger creation_date: 2011-03-07T11:28:29Z [Term] id: GO:0035724 name: CD24 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation." [GOC:BHF] synonym: "CD24 anabolism" EXACT [GOC:bf] synonym: "CD24 biosynthesis" EXACT [GOC:bf] synonym: "CD24 formation" EXACT [GOC:bf] synonym: "CD24 synthesis" EXACT [GOC:bf] is_a: GO:0009101 ! glycoprotein biosynthetic process created_by: rfoulger creation_date: 2011-03-07T11:32:54Z [Term] id: GO:0035725 name: sodium ion transmembrane transport namespace: biological_process def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "sodium ion membrane transport" EXACT [] is_a: GO:0006814 ! sodium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: rfoulger creation_date: 2011-03-10T02:52:36Z [Term] id: GO:0035726 name: common myeloid progenitor cell proliferation namespace: biological_process def: "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage." [CL:0000049, GOC:BHF] is_a: GO:0008283 ! cell population proliferation created_by: rfoulger creation_date: 2011-03-10T02:57:19Z [Term] id: GO:0035727 name: lysophosphatidic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors." [GOC:curators] synonym: "LPA binding" EXACT [] is_a: GO:0005543 ! phospholipid binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: rfoulger creation_date: 2011-03-10T03:00:05Z [Term] id: GO:0035728 name: response to hepatocyte growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] synonym: "response to hepatocyte growth factor stimulus" EXACT [GOC:dos] synonym: "response to HGF stimulus" EXACT [GOC:bf] is_a: GO:0070848 ! response to growth factor created_by: rfoulger creation_date: 2011-03-10T03:02:47Z [Term] id: GO:0035729 name: cellular response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] synonym: "cellular response to HGF stimulus" EXACT [GOC:bf] is_a: GO:0035728 ! response to hepatocyte growth factor is_a: GO:0071363 ! cellular response to growth factor stimulus created_by: rfoulger creation_date: 2011-03-10T03:04:19Z [Term] id: GO:0035730 name: S-nitrosoglutathione binding namespace: molecular_function def: "Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [GOC:BHF] synonym: "GSNO binding" EXACT [] is_a: GO:1901681 ! sulfur compound binding created_by: rfoulger creation_date: 2011-03-11T09:57:19Z [Term] id: GO:0035731 name: dinitrosyl-iron complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO." [GOC:BHF, PMID:10534443] synonym: "dinitrosyl-diglutathionyl-iron complex binding" EXACT [PMID:12871931] synonym: "DNDGIC binding" EXACT [PMID:12871931] synonym: "DNIC binding" EXACT [PMID:10534443] is_a: GO:0005488 ! binding created_by: rfoulger creation_date: 2011-03-11T09:58:31Z [Term] id: GO:0035732 name: nitric oxide storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins." [GOC:BHF, PMID:12871945] synonym: "NO storage" EXACT [GOC:bf] is_a: GO:0051179 ! localization relationship: part_of GO:0033484 ! nitric oxide homeostasis created_by: rfoulger creation_date: 2011-03-11T10:00:31Z [Term] id: GO:0035733 name: hepatic stellate cell activation namespace: biological_process def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf] is_a: GO:0072537 ! fibroblast activation created_by: rfoulger creation_date: 2011-03-11T10:04:12Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924.2 is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: part_of GO:0060271 ! cilium assembly relationship: part_of GO:0060271 ! cilium assembly created_by: rfoulger creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035736 name: cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001745 ! compound eye morphogenesis relationship: part_of GO:0001745 ! compound eye morphogenesis created_by: rfoulger creation_date: 2011-03-17T10:57:03Z [Term] id: GO:0035737 name: injection of substance in to other organism namespace: biological_process def: "The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes." [GOC:pamgo_curators] is_a: GO:0051705 ! multi-organism behavior created_by: rfoulger creation_date: 2011-03-17T10:58:57Z [Term] id: GO:0035738 name: envenomation resulting in modification of morphology or physiology of other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism." [GOC:pamgo_curators] is_a: GO:0035737 ! injection of substance in to other organism intersection_of: GO:0035737 ! injection of substance in to other organism intersection_of: has_part GO:0035821 ! modification of morphology or physiology of other organism relationship: has_part GO:0035821 ! modification of morphology or physiology of other organism created_by: rfoulger creation_date: 2011-03-17T10:59:27Z [Term] id: GO:0035739 name: CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046633 ! alpha-beta T cell proliferation created_by: rfoulger creation_date: 2011-03-17T02:12:48Z [Term] id: GO:0035740 name: CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF] is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation is_a: GO:0046633 ! alpha-beta T cell proliferation created_by: rfoulger creation_date: 2011-03-17T02:13:54Z [Term] id: GO:0035741 name: activated CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF] is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation created_by: rfoulger creation_date: 2011-03-17T02:18:39Z [Term] id: GO:0035742 name: activated CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF] is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation created_by: rfoulger creation_date: 2011-03-17T02:19:58Z [Term] id: GO:0035743 name: CD4-positive, alpha-beta T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF] is_a: GO:0002369 ! T cell cytokine production created_by: rfoulger creation_date: 2011-03-17T02:21:51Z [Term] id: GO:0035744 name: T-helper 1 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF] synonym: "Th1 cell cytokine production" EXACT [CL:0000545] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production relationship: part_of GO:0042088 ! T-helper 1 type immune response created_by: rfoulger creation_date: 2011-03-17T02:22:54Z [Term] id: GO:0035745 name: T-helper 2 cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF] synonym: "Th2 cell cytokine production" EXACT [CL:0000546] is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production relationship: part_of GO:0042092 ! type 2 immune response created_by: rfoulger creation_date: 2011-03-17T02:23:32Z [Term] id: GO:0035746 name: granzyme A production namespace: biological_process def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: rfoulger creation_date: 2011-03-17T02:39:11Z [Term] id: GO:0035747 name: natural killer cell chemotaxis namespace: biological_process def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis created_by: rfoulger creation_date: 2011-03-17T02:40:10Z [Term] id: GO:0035748 name: myelin sheath abaxonal region namespace: cellular_component def: "The region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043209 ! myelin sheath created_by: rfoulger creation_date: 2011-03-23T10:16:14Z [Term] id: GO:0035749 name: myelin sheath adaxonal region namespace: cellular_component def: "The region of the myelin sheath nearest to the axon." [GOC:BHF, PMID:20237282] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043209 ! myelin sheath created_by: rfoulger creation_date: 2011-03-23T10:17:42Z [Term] id: GO:0035750 name: protein localization to myelin sheath abaxonal region namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] synonym: "protein localisation to myelin sheath abaxonal region" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization created_by: rfoulger creation_date: 2011-03-23T10:20:06Z [Term] id: GO:0035751 name: regulation of lysosomal lumen pH namespace: biological_process def: "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph] is_a: GO:0051453 ! regulation of intracellular pH relationship: part_of GO:0007040 ! lysosome organization created_by: rfoulger creation_date: 2011-03-23T10:23:41Z [Term] id: GO:0035752 name: lysosomal lumen pH elevation namespace: biological_process def: "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:bf, GOC:rph] synonym: "lysosome pH elevation" EXACT [GOC:bf, GOC:rph] is_a: GO:0035751 ! regulation of lysosomal lumen pH is_a: GO:0051454 ! intracellular pH elevation created_by: rfoulger creation_date: 2011-03-23T10:24:24Z [Term] id: GO:0035753 name: maintenance of DNA trinucleotide repeats namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs." [GOC:rb, PMID:21347277, SO:0000291] is_a: GO:0043570 ! maintenance of DNA repeat elements created_by: rfoulger creation_date: 2011-03-23T10:29:02Z [Term] id: GO:0035754 name: B cell chemotaxis namespace: biological_process def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF] is_a: GO:0048247 ! lymphocyte chemotaxis created_by: rfoulger creation_date: 2011-03-23T10:30:33Z [Term] id: GO:0035755 name: cardiolipin hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA)." [GOC:sp, PMID:17028579, PMID:21397848] xref: Reactome:R-HSA-8954398 "PLD6 dimer hydrolyses cardiolipin to PA and PG" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity created_by: rfoulger creation_date: 2011-03-24T10:14:05Z [Term] id: GO:0035756 name: transepithelial migration of symbiont in host namespace: biological_process def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460] synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf] synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf] is_a: GO:0044001 ! migration in host created_by: rfoulger creation_date: 2011-03-24T10:20:03Z [Term] id: GO:0035757 name: chemokine (C-C motif) ligand 19 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19." [GOC:BHF] synonym: "CCL19 binding" EXACT [GOC:bf] is_a: GO:0019957 ! C-C chemokine binding created_by: rfoulger creation_date: 2011-03-25T02:02:36Z [Term] id: GO:0035758 name: chemokine (C-C motif) ligand 21 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21." [GOC:BHF] synonym: "CCL21 binding" EXACT [GOC:bf] is_a: GO:0019957 ! C-C chemokine binding created_by: rfoulger creation_date: 2011-03-25T02:03:53Z [Term] id: GO:0035759 name: mesangial cell-matrix adhesion namespace: biological_process def: "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney." [CL:0000650, GOC:BHF, PMID:15569314] is_a: GO:0007160 ! cell-matrix adhesion created_by: rfoulger creation_date: 2011-03-25T02:06:21Z [Term] id: GO:0035760 name: cytoplasmic polyadenylation-dependent rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444] synonym: "cytoplasmic poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] is_a: GO:0016075 ! rRNA catabolic process is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process created_by: rfoulger creation_date: 2011-03-25T02:14:50Z [Term] id: GO:0035761 name: dorsal motor nucleus of vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state." [GOC:dgh] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development created_by: rfoulger creation_date: 2011-03-29T02:45:50Z [Term] id: GO:0035762 name: dorsal motor nucleus of vagus nerve morphogenesis namespace: biological_process def: "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development created_by: rfoulger creation_date: 2011-03-29T02:47:18Z [Term] id: GO:0035763 name: dorsal motor nucleus of vagus nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "dorsal motor nucleus of vagus nerve structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis created_by: rfoulger creation_date: 2011-03-29T02:47:56Z [Term] id: GO:0035764 name: dorsal motor nucleus of vagus nerve formation namespace: biological_process def: "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis created_by: rfoulger creation_date: 2011-03-29T02:48:26Z [Term] id: GO:0035765 name: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation namespace: biological_process def: "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve." [GOC:dgh, PMID:21262462] is_a: GO:0021535 ! cell migration in hindbrain intersection_of: GO:0021535 ! cell migration in hindbrain intersection_of: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation relationship: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation created_by: rfoulger creation_date: 2011-03-29T02:52:09Z [Term] id: GO:0035766 name: cell chemotaxis to fibroblast growth factor namespace: biological_process def: "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF)." [GOC:BHF] is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus created_by: rfoulger creation_date: 2011-03-31T04:30:16Z [Term] id: GO:0035767 name: endothelial cell chemotaxis namespace: biological_process def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF] is_a: GO:0043542 ! endothelial cell migration is_a: GO:0060326 ! cell chemotaxis created_by: rfoulger creation_date: 2011-03-31T04:31:37Z [Term] id: GO:0035768 name: endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF)." [CL:0000115, GOC:BHF] is_a: GO:0035766 ! cell chemotaxis to fibroblast growth factor is_a: GO:0035767 ! endothelial cell chemotaxis created_by: rfoulger creation_date: 2011-03-31T04:32:17Z [Term] id: GO:0035769 name: B cell chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a B cell to cross a high endothelial venule in response to an external stimulus." [CL:0000236, GOC:BHF] synonym: "B-cell chemotaxis across high endothelial venule" EXACT [GOC:ebc] is_a: GO:0002518 ! lymphocyte chemotaxis across high endothelial venule is_a: GO:0035754 ! B cell chemotaxis created_by: rfoulger creation_date: 2011-04-01T10:48:59Z [Term] id: GO:0035770 name: ribonucleoprotein granule namespace: cellular_component def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] synonym: "mRNP granule" EXACT [] synonym: "RNA granule" NARROW [] synonym: "RNP granule" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0099080 ! supramolecular complex created_by: rfoulger creation_date: 2011-04-01T10:50:47Z [Term] id: GO:0035771 name: interleukin-4-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] synonym: "IL-4-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-4-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071353 ! cellular response to interleukin-4 created_by: rfoulger creation_date: 2011-04-01T10:56:46Z [Term] id: GO:0035772 name: interleukin-13-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] synonym: "IL-13-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-13-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0035963 ! cellular response to interleukin-13 created_by: rfoulger creation_date: 2011-04-01T11:00:11Z [Term] id: GO:0035773 name: insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0030073 ! insulin secretion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0030073 ! insulin secretion intersection_of: part_of GO:0071333 ! cellular response to glucose stimulus relationship: part_of GO:0071333 ! cellular response to glucose stimulus created_by: rfoulger creation_date: 2011-04-01T01:14:40Z [Term] id: GO:0035774 name: positive regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] is_a: GO:0032024 ! positive regulation of insulin secretion is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus created_by: rfoulger creation_date: 2011-04-01T01:49:09Z [Term] id: GO:0035775 name: pronephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0039021 ! pronephric glomerulus development created_by: rfoulger creation_date: 2011-04-04T10:59:28Z [Term] id: GO:0035776 name: pronephric proximal tubule development namespace: biological_process def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072014 ! proximal tubule development created_by: rfoulger creation_date: 2011-04-04T11:02:54Z [Term] id: GO:0035777 name: pronephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039020 ! pronephric nephron tubule development is_a: GO:0072017 ! distal tubule development created_by: rfoulger creation_date: 2011-04-04T11:06:01Z [Term] id: GO:0035778 name: pronephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] is_a: GO:0039014 ! cell differentiation involved in pronephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation relationship: part_of GO:0039020 ! pronephric nephron tubule development created_by: rfoulger creation_date: 2011-04-04T11:07:47Z [Term] id: GO:0035779 name: angioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0001568 ! blood vessel development created_by: rfoulger creation_date: 2011-04-04T11:10:38Z [Term] id: GO:0035780 name: CD80 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] synonym: "CD80 anabolism" EXACT [GOC:bf] synonym: "CD80 biosynthesis" EXACT [GOC:bf] synonym: "CD80 formation" EXACT [GOC:bf] synonym: "CD80 synthesis" EXACT [GOC:bf] is_a: GO:0009101 ! glycoprotein biosynthetic process created_by: rfoulger creation_date: 2011-04-04T11:18:41Z [Term] id: GO:0035781 name: CD86 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] synonym: "CD86 anabolism" EXACT [GOC:bf] synonym: "CD86 biosynthesis" EXACT [GOC:bf] synonym: "CD86 formation" EXACT [GOC:bf] synonym: "CD86 synthesis" EXACT [GOC:bf] is_a: GO:0009101 ! glycoprotein biosynthetic process created_by: rfoulger creation_date: 2011-04-04T11:20:40Z [Term] id: GO:0035782 name: mature natural killer cell chemotaxis namespace: biological_process def: "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules." [CL:0000824, GOC:BHF] synonym: "activated natural killer cell chemotaxis" EXACT [GOC:ebc] is_a: GO:0035747 ! natural killer cell chemotaxis created_by: rfoulger creation_date: 2011-04-04T11:23:13Z [Term] id: GO:0035783 name: CD4-positive, alpha-beta T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation." [CL:0000624, GOC:BHF, GOC:pr] synonym: "CD4-positive, alpha beta T cell costimulation" EXACT [] is_a: GO:0031295 ! T cell costimulation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation created_by: rfoulger creation_date: 2011-04-04T11:28:52Z [Term] id: GO:0035784 name: nickel cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell." [GOC:kmv] synonym: "nickel homeostasis" EXACT [GOC:bf] is_a: GO:0055076 ! transition metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: rfoulger creation_date: 2011-04-05T09:55:14Z [Term] id: GO:0035785 name: cellular nickel ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell." [GOC:kmv] synonym: "cellular nickel homeostasis" EXACT [GOC:bf] is_a: GO:0035784 ! nickel cation homeostasis is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis created_by: rfoulger creation_date: 2011-04-05T09:55:56Z [Term] id: GO:0035787 name: cell migration involved in kidney development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development created_by: rfoulger creation_date: 2011-04-06T10:39:52Z [Term] id: GO:0035788 name: cell migration involved in metanephros development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf] is_a: GO:0035787 ! cell migration involved in kidney development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: rfoulger creation_date: 2011-04-06T10:42:21Z [Term] id: GO:0035789 name: metanephric mesenchymal cell migration namespace: biological_process def: "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101, PMID:19019919] synonym: "metanephric mesenchyme chemotaxis" NARROW [PMID:19019919] is_a: GO:0035788 ! cell migration involved in metanephros development created_by: rfoulger creation_date: 2011-04-06T10:45:15Z [Term] id: GO:0035790 name: platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961, PR:000002030] synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf] synonym: "platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway created_by: rfoulger creation_date: 2011-04-06T10:55:16Z [Term] id: GO:0035791 name: platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961, PR:000002035] synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf] synonym: "platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway created_by: rfoulger creation_date: 2011-04-06T10:57:04Z [Term] id: GO:0035792 name: host cell postsynaptic membrane namespace: cellular_component def: "A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane." [GOC:ecd] synonym: "other organism post-synaptic membrane" EXACT [] synonym: "other organism postsynaptic membrane" RELATED [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane created_by: rfoulger creation_date: 2011-04-08T01:21:20Z [Term] id: GO:0035793 name: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101] synonym: "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway" EXACT [PMID:10734101] synonym: "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway" EXACT [GOC:bf] synonym: "positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] is_a: GO:1900238 ! regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway is_a: GO:2000591 ! positive regulation of metanephric mesenchymal cell migration intersection_of: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway intersection_of: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration created_by: rfoulger creation_date: 2011-04-11T01:30:03Z [Term] id: GO:0035794 name: positive regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] synonym: "mitochondrial membrane permeability transition" NARROW [PMID:17136322] synonym: "mitochondrial membrane permeabilization" NARROW [PMID:12546810] synonym: "mitochondrial permeability transition" NARROW [PMID:21424245] synonym: "MPT" NARROW [] synonym: "positive regulation of transport across mitochondrial membrane" EXACT [GOC:bf] is_a: GO:0046902 ! regulation of mitochondrial membrane permeability is_a: GO:1905710 ! positive regulation of membrane permeability created_by: rfoulger creation_date: 2011-04-11T01:44:06Z [Term] id: GO:0035795 name: negative regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [PMID:10781072] synonym: "mitochondrial membrane impermeability" RELATED [PMID:10781072] synonym: "mitochondrial membrane impermeabilization" NARROW [GOC:bf] synonym: "negative regulation of transport across mitochondrial membrane" EXACT [GOC:bf] is_a: GO:0046902 ! regulation of mitochondrial membrane permeability is_a: GO:1905709 ! negative regulation of membrane permeability created_by: rfoulger creation_date: 2011-04-11T01:45:26Z [Term] id: GO:0035796 name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing namespace: cellular_component def: "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [PMID:18931129, PMID:20972419, PMID:21135102] comment: The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane. synonym: "ATP-binding cassette (ABC) transporter complex, ECF-type" EXACT [GOC:bf] synonym: "energy coupling factor (ECF)-type ABC transporter" EXACT [PMID:21135102] synonym: "energy-coupling factor transporter" EXACT [PMID:18931129] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex created_by: rfoulger creation_date: 2011-04-11T02:02:41Z [Term] id: GO:0035797 name: tellurite methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)." [GOC:bf, GOC:kad, PMID:11053398, PMID:21244361] synonym: "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity" EXACT [GOC:bf] synonym: "SAM-dependent tellurite methyltransferase activity" EXACT [GOC:bf] synonym: "tellurite methylase activity" BROAD [GOC:bf] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: rfoulger creation_date: 2011-04-14T01:06:19Z [Term] id: GO:0035798 name: 2-alkenal reductase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+." [GOC:bf, GOC:kad, PMID:16299173] synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [GOC:bf, GOC:kad] is_a: GO:0032440 ! 2-alkenal reductase [NAD(P)+] activity created_by: rfoulger creation_date: 2011-04-14T01:11:07Z [Term] id: GO:0035799 name: ureter maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463] is_a: GO:0048799 ! animal organ maturation relationship: part_of GO:0072189 ! ureter development created_by: rfoulger creation_date: 2011-04-14T01:13:39Z [Term] id: GO:0035800 name: deubiquitinase activator activity namespace: molecular_function def: "Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences." [GOC:sart, ISBN:0120793709] is_a: GO:0016504 ! peptidase activator activity relationship: part_of GO:2000158 ! positive regulation of ubiquitin-specific protease activity creation_date: 2011-04-18T10:20:15Z [Term] id: GO:0035801 name: adrenal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex] synonym: "adrenal gland cortex development" EXACT [MA:0000118] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030325 ! adrenal gland development created_by: rfoulger creation_date: 2011-04-18T10:25:39Z [Term] id: GO:0035802 name: adrenal cortex formation namespace: biological_process def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154] synonym: "adrenal gland cortex formation" EXACT [MA:0000118] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035801 ! adrenal cortex development created_by: rfoulger creation_date: 2011-04-18T10:26:49Z [Term] id: GO:0035803 name: egg coat formation namespace: biological_process def: "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [GOC:bf, GOC:sart, GOC:yaf, PMID:16944418, PMID:17163408] synonym: "VE formation" NARROW [PMID:16944418, PMID:17163408] synonym: "vitelline envelope formation" NARROW [PMID:16944418] synonym: "zona pellucida assembly" NARROW [GOC:yaf, PMID:18420282] synonym: "ZP assembly" NARROW [PMID:18420282] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048477 ! oogenesis created_by: rfoulger creation_date: 2011-04-19T01:48:43Z [Term] id: GO:0035804 name: structural constituent of egg coat namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] synonym: "structural constituent of vitelline envelope" NARROW [PMID:16944418, PMID:17163408] synonym: "structural constituent of zona pellucida" NARROW [PMID:16944418, PMID:17163408] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0035805 ! egg coat relationship: occurs_in GO:0035805 ! egg coat created_by: rfoulger creation_date: 2011-04-19T01:56:06Z [Term] id: GO:0035805 name: egg coat namespace: cellular_component def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408] synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408] is_a: GO:0030312 ! external encapsulating structure created_by: rfoulger creation_date: 2011-04-19T02:07:23Z [Term] id: GO:0035806 name: modulation of blood coagulation in other organism namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj] synonym: "modulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "modulation by organism of blood coagulation in other organism" EXACT [GOC:bf] synonym: "regulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "regulation of blood clotting in other organism" EXACT [GOC:bf] synonym: "regulation of blood coagulation in other organism" EXACT [GOC:bf] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: rfoulger creation_date: 2011-04-20T11:38:49Z [Term] id: GO:0035807 name: positive regulation of blood coagulation in other organism namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj, PMID:12362232] synonym: "positive regulation by organism of blood clotting in other organism" EXACT [GOC:bf] synonym: "positive regulation by organism of blood coagulation in other organism" EXACT [GOC:bf] synonym: "positive regulation of blood clotting in other organism" EXACT [GOC:bf] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0035806 ! modulation of blood coagulation in other organism created_by: rfoulger creation_date: 2011-04-20T11:43:37Z [Term] id: GO:0035808 name: meiotic recombination initiation complex namespace: cellular_component def: "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins." [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000794 ! condensed nuclear chromosome created_by: rfoulger creation_date: 2011-04-20T11:52:50Z [Term] id: GO:0035809 name: regulation of urine volume namespace: biological_process def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] synonym: "regulation of urinary volume" EXACT [] synonym: "regulation of urine flow" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050878 ! regulation of body fluid levels created_by: rfoulger creation_date: 2011-04-20T01:17:38Z [Term] id: GO:0035810 name: positive regulation of urine volume namespace: biological_process def: "Any process that increases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] synonym: "diuresis" BROAD [GOC:mtg_25march11] synonym: "elevation of urinary volume" EXACT [GOC:mtg_25march11] synonym: "increase in urine flow" EXACT [GOC:mtg_25march11] is_a: GO:0035809 ! regulation of urine volume created_by: rfoulger creation_date: 2011-04-20T01:19:38Z [Term] id: GO:0035811 name: negative regulation of urine volume namespace: biological_process def: "Any process that decreases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] synonym: "antidiuresis" BROAD [GOC:mtg_25march11] synonym: "decrease in urine flow" EXACT [GOC:mtg_25march11] synonym: "reduction of urinary volume" EXACT [GOC:mtg_25march11] is_a: GO:0035809 ! regulation of urine volume created_by: rfoulger creation_date: 2011-04-20T01:21:01Z [Term] id: GO:0035812 name: renal sodium excretion namespace: biological_process def: "The elimination by an organism of sodium in the urine." [GOC:mtg_25march11, GOC:yaf] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion relationship: part_of GO:0055078 ! sodium ion homeostasis created_by: rfoulger creation_date: 2011-04-20T01:24:16Z [Term] id: GO:0035813 name: regulation of renal sodium excretion namespace: biological_process def: "Any process that modulates the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] is_a: GO:0044062 ! regulation of excretion is_a: GO:0065008 ! regulation of biological quality is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035812 ! renal sodium excretion relationship: regulates GO:0035812 ! renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T01:26:30Z [Term] id: GO:0035814 name: negative regulation of renal sodium excretion namespace: biological_process def: "Any process that decreases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine. is_a: GO:0035813 ! regulation of renal sodium excretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035812 ! renal sodium excretion relationship: negatively_regulates GO:0035812 ! renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T01:27:39Z [Term] id: GO:0035815 name: positive regulation of renal sodium excretion namespace: biological_process def: "Any process that increases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] comment: The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine. synonym: "natriuresis" BROAD [GOC:mtg_25march11] is_a: GO:0035813 ! regulation of renal sodium excretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035812 ! renal sodium excretion relationship: positively_regulates GO:0035812 ! renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T01:29:26Z [Term] id: GO:0035816 name: renal water absorption involved in negative regulation of urine volume namespace: biological_process def: "Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time." [GOC:mtg_25march11, GOC:yaf] is_a: GO:0070295 ! renal water absorption intersection_of: GO:0070295 ! renal water absorption intersection_of: part_of GO:0035811 ! negative regulation of urine volume relationship: part_of GO:0035811 ! negative regulation of urine volume created_by: rfoulger creation_date: 2011-04-20T01:37:34Z [Term] id: GO:0035817 name: renal sodium ion absorption involved in negative regulation of renal sodium excretion namespace: biological_process def: "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time." [GOC:mtg_25march11, GOC:yaf] is_a: GO:0070294 ! renal sodium ion absorption intersection_of: GO:0070294 ! renal sodium ion absorption intersection_of: part_of GO:0035814 ! negative regulation of renal sodium excretion relationship: part_of GO:0035814 ! negative regulation of renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T01:40:11Z [Term] id: GO:0035818 name: positive regulation of urine volume by pressure natriuresis namespace: biological_process def: "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf] synonym: "diuresis resulting from pressure natriuresis" RELATED [GOC:mtg_25march11] is_a: GO:0003095 ! pressure natriuresis is_a: GO:0035810 ! positive regulation of urine volume created_by: rfoulger creation_date: 2011-04-20T01:55:42Z [Term] id: GO:0035819 name: positive regulation of renal sodium excretion by pressure natriuresis namespace: biological_process def: "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf] synonym: "natriuresis resulting from pressure natriuresis" RELATED [] is_a: GO:0003095 ! pressure natriuresis is_a: GO:0035815 ! positive regulation of renal sodium excretion intersection_of: GO:0003095 ! pressure natriuresis intersection_of: positively_regulates GO:0035812 ! renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T01:57:20Z [Term] id: GO:0035820 name: negative regulation of renal sodium excretion by angiotensin namespace: biological_process def: "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] is_a: GO:0003083 ! negative regulation of renal output by angiotensin is_a: GO:0035814 ! negative regulation of renal sodium excretion created_by: rfoulger creation_date: 2011-04-20T02:10:50Z [Term] id: GO:0035821 name: modification of morphology or physiology of other organism namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a second organism." [GOC:bf] synonym: "regulation of morphology of other organism" NARROW [GOC:bf] synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf] synonym: "regulation of physiological process of other organism" NARROW [GOC:bf] synonym: "regulation of physiology of other organism" NARROW [GOC:bf] is_a: GO:0044419 ! interspecies interaction between organisms created_by: rfoulger creation_date: 2011-04-21T01:31:51Z [Term] id: GO:0035822 name: gene conversion namespace: biological_process def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor." [GOC:mah, PMID:17846636] is_a: GO:0006310 ! DNA recombination created_by: rfoulger creation_date: 2011-05-04T01:04:39Z [Term] id: GO:0035823 name: short tract gene conversion namespace: biological_process def: "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] is_a: GO:0035822 ! gene conversion created_by: rfoulger creation_date: 2011-05-04T01:05:35Z [Term] id: GO:0035824 name: long tract gene conversion namespace: biological_process def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] is_a: GO:0035822 ! gene conversion created_by: rfoulger creation_date: 2011-05-04T01:06:18Z [Term] id: GO:0035825 name: homologous recombination namespace: biological_process def: "A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] synonym: "chromosomal crossover" RELATED [GOC:mah, Wikipedia:Chromosomal_crossover] synonym: "interchromosomal DNA recombination" EXACT [] synonym: "interstrand DNA recombination" EXACT [] synonym: "reciprocal DNA recombination" NARROW [] xref: Wikipedia:Chromosomal_crossover is_a: GO:0006310 ! DNA recombination created_by: rfoulger creation_date: 2011-05-04T01:23:31Z [Term] id: GO:0035826 name: obsolete rubidium ion transport namespace: biological_process def: "OBSOLETE. The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "Rb+ transport" EXACT [] synonym: "rubidium cation transport" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2011-05-04T02:53:27Z [Term] id: GO:0035827 name: obsolete rubidium ion transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of rubidium ions (Rb+) from one side of a membrane to the other." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "Rb+ transmembrane transporter activity" EXACT [] synonym: "rubidium cation transmembrane transporter activity" EXACT [] synonym: "rubidium transmembrane transporter activity" RELATED [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2011-05-04T02:55:30Z [Term] id: GO:0035828 name: obsolete renal rubidium ion transport namespace: biological_process def: "OBSOLETE. The directed movement of rubidium ions (Rb+) by the kidney." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "renal Rb+ transport" EXACT [] synonym: "renal rubidium cation transport" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2011-05-04T02:58:50Z [Term] id: GO:0035829 name: obsolete renal rubidium ion absorption namespace: biological_process def: "OBSOLETE. A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "renal Rb+ absorption" EXACT [] synonym: "renal rubidium cation absorption" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2011-05-04T03:01:05Z [Term] id: GO:0035830 name: palmatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants." [GOC:yaf] synonym: "palmatine metabolism" EXACT [GOC:bf] is_a: GO:0033076 ! isoquinoline alkaloid metabolic process created_by: rfoulger creation_date: 2011-05-04T03:04:38Z [Term] id: GO:0035831 name: palmatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants." [GOC:yaf] synonym: "palmatine anabolism" EXACT [GOC:bf] synonym: "palmatine biosynthesis" EXACT [GOC:bf] synonym: "palmatine formation" EXACT [GOC:bf] synonym: "palmatine synthesis" EXACT [GOC:bf] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0035830 ! palmatine metabolic process created_by: rfoulger creation_date: 2011-05-04T03:06:06Z [Term] id: GO:0035832 name: berbamunine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid." [GOC:yaf] synonym: "berbamunine metabolism" EXACT [GOC:bf] is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: rfoulger creation_date: 2011-05-04T03:11:18Z [Term] id: GO:0035833 name: berbamunine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid." [GOC:yaf] synonym: "berbamunine anabolism" EXACT [GOC:bf] synonym: "berbamunine biosynthesis" EXACT [GOC:bf] synonym: "berbamunine formation" EXACT [GOC:bf] synonym: "berbamunine synthesis" EXACT [GOC:bf] is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process is_a: GO:0035832 ! berbamunine metabolic process created_by: rfoulger creation_date: 2011-05-04T03:12:03Z [Term] id: GO:0035834 name: indole alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] synonym: "indole alkaloid metabolism" EXACT [GOC:bf] is_a: GO:0009820 ! alkaloid metabolic process created_by: rfoulger creation_date: 2011-05-04T03:17:44Z [Term] id: GO:0035835 name: indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] synonym: "indole alkaloid anabolism" EXACT [GOC:bf] synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf] synonym: "indole alkaloid formation" EXACT [GOC:bf] synonym: "indole alkaloid synthesis" EXACT [GOC:bf] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0035834 ! indole alkaloid metabolic process created_by: rfoulger creation_date: 2011-05-04T03:18:31Z [Term] id: GO:0035836 name: ergot alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid." [GOC:yaf] synonym: "ergot alkaloid metabolism" EXACT [GOC:bf] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process created_by: rfoulger creation_date: 2011-05-04T03:23:13Z [Term] id: GO:0035837 name: ergot alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an ergot alkaloid." [GOC:yaf] synonym: "ergot alkaloid anabolism" EXACT [GOC:bf] synonym: "ergot alkaloid biosynthesis" EXACT [GOC:bf] synonym: "ergot alkaloid formation" EXACT [GOC:bf] synonym: "ergot alkaloid synthesis" EXACT [GOC:bf] is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process is_a: GO:0035836 ! ergot alkaloid metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process created_by: rfoulger creation_date: 2011-05-04T03:23:57Z [Term] id: GO:0035838 name: growing cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah] synonym: "growing cell end" EXACT [GOC:mah] is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip created_by: rfoulger creation_date: 2011-05-06T01:28:44Z [Term] id: GO:0035839 name: non-growing cell tip namespace: cellular_component def: "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "new cell end" RELATED [GOC:mah] synonym: "non-growing cell end" EXACT [GOC:mah] is_a: GO:0051286 ! cell tip created_by: rfoulger creation_date: 2011-05-06T01:32:21Z [Term] id: GO:0035840 name: old growing cell tip namespace: cellular_component def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "old growing cell end" EXACT [GOC:mah] is_a: GO:0035838 ! growing cell tip created_by: rfoulger creation_date: 2011-05-06T01:33:54Z [Term] id: GO:0035841 name: new growing cell tip namespace: cellular_component def: "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth." [GOC:expert_jd, GOC:mah, PMID:19431238] synonym: "new cell tip after activation of bipolar cell growth" EXACT [GOC:bf] synonym: "post-NETO new cell end" EXACT [GOC:mah] synonym: "post-NETO new cell tip" EXACT [GOC:mah] synonym: "post-new end take-off new cell tip" EXACT [GOC:mah] is_a: GO:0035838 ! growing cell tip created_by: rfoulger creation_date: 2011-05-06T01:35:07Z [Term] id: GO:0035842 name: old cell tip after activation of bipolar cell growth namespace: cellular_component def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] synonym: "post-NETO old cell end" EXACT [GOC:mah] synonym: "post-NETO old cell tip" EXACT [GOC:mah] synonym: "post-new end take-off old cell tip" EXACT [GOC:mah] is_a: GO:0035840 ! old growing cell tip created_by: rfoulger creation_date: 2011-05-06T01:37:23Z [Term] id: GO:0035843 name: endonuclear canal namespace: cellular_component def: "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope." [GOC:bf, PMID:18359585] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0001673 ! male germ cell nucleus created_by: rfoulger creation_date: 2011-05-06T01:45:03Z [Term] id: GO:0035844 name: cloaca development namespace: biological_process def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] synonym: "cloacal development" EXACT [GOC:bf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001655 ! urogenital system development relationship: part_of GO:0048546 ! digestive tract morphogenesis created_by: rfoulger creation_date: 2011-05-06T01:54:35Z [Term] id: GO:0035845 name: photoreceptor cell outer segment organization namespace: biological_process def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials." [ISBN:0824072820, PMID:14507858] synonym: "photoreceptor cell outer segment organisation" EXACT [GOC:mah] synonym: "photoreceptor outer segment organization" EXACT [GOC:bf] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0042461 ! photoreceptor cell development created_by: rfoulger creation_date: 2011-05-10T10:44:09Z [Term] id: GO:0035846 name: oviduct epithelium development namespace: biological_process def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube epithelium development" NARROW [GOC:yaf] is_a: GO:0048608 ! reproductive structure development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060066 ! oviduct development created_by: rfoulger creation_date: 2011-05-10T10:53:05Z [Term] id: GO:0035847 name: uterine epithelium development namespace: biological_process def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf] synonym: "uterus epithelial development" EXACT [GOC:yaf] is_a: GO:0035846 ! oviduct epithelium development relationship: part_of GO:0060065 ! uterus development created_by: rfoulger creation_date: 2011-05-10T10:57:45Z [Term] id: GO:0035848 name: oviduct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0060066 ! oviduct development created_by: rfoulger creation_date: 2011-05-10T11:01:20Z [Term] id: GO:0035849 name: nephric duct elongation namespace: biological_process def: "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0072178 ! nephric duct morphogenesis created_by: rfoulger creation_date: 2011-05-11T11:31:39Z [Term] id: GO:0035850 name: epithelial cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0001822 ! kidney development created_by: rfoulger creation_date: 2011-05-11T11:34:21Z [Term] id: GO:0035851 name: Krueppel-associated box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors." [InterPro:IPR001909] synonym: "KRAB domain binding" EXACT [InterPro:IPR001909] synonym: "Krueppel-associated box binding" EXACT [InterPro:IPR001909] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2011-05-11T11:41:16Z [Term] id: GO:0035852 name: horizontal cell localization namespace: biological_process def: "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina." [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249] synonym: "horizontal cell localisation" EXACT [GOC:mah] synonym: "horizontal cell positioning" EXACT [PMID:18094249] synonym: "laminar positioning of retinal horizontal cell" EXACT [PMID:18094249] synonym: "retinal horizontal cell positioning" EXACT [PMID:18094249] is_a: GO:0051674 ! localization of cell relationship: part_of GO:0010842 ! retina layer formation created_by: rfoulger creation_date: 2011-05-11T01:56:40Z [Term] id: GO:0035853 name: chromosome passenger complex localization to spindle midzone namespace: biological_process def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:mah, GOC:vw, PMID:15296749] synonym: "chromosomal passenger complex localization to spindle midzone" EXACT [GOC:bf] synonym: "chromosome passenger complex localisation to spindle midzone" EXACT [GOC:bf] synonym: "chromosome passenger complex localization to central spindle" EXACT [PMID:14528012] synonym: "chromosome passenger complex localization to spindle equator" EXACT [GOC:bf] synonym: "CPC complex localization to spindle midzone" EXACT [GOC:bf] synonym: "CPC localization to spindle midzone" EXACT [GOC:bf] is_a: GO:0034629 ! cellular protein-containing complex localization is_a: GO:0044380 ! protein localization to cytoskeleton created_by: rfoulger creation_date: 2011-05-13T01:19:51Z [Term] id: GO:0035854 name: eosinophil fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate commitment" EXACT [GOC:bf] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030222 ! eosinophil differentiation created_by: rfoulger creation_date: 2011-05-13T01:23:28Z [Term] id: GO:0035855 name: megakaryocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] synonym: "megakaryocyte cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development is_a: GO:0098751 ! bone cell development relationship: part_of GO:0030219 ! megakaryocyte differentiation created_by: rfoulger creation_date: 2011-05-13T01:28:06Z [Term] id: GO:0035857 name: eosinophil fate specification namespace: biological_process def: "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate specification" EXACT [GOC:bf] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0035854 ! eosinophil fate commitment created_by: rfoulger creation_date: 2011-05-17T10:42:54Z [Term] id: GO:0035858 name: eosinophil fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000771, GOC:BHF, GOC:vk] synonym: "eosinophil cell fate determination" EXACT [GOC:bf] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0035854 ! eosinophil fate commitment created_by: rfoulger creation_date: 2011-05-17T10:43:35Z [Term] id: GO:0035859 name: Seh1-associated complex namespace: cellular_component def: "A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] synonym: "GATOR complex" EXACT [GOC:rb, PMID:23723238] synonym: "SEA complex" EXACT [GOC:jh, PMID:21454883] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2011-05-17T10:59:50Z [Term] id: GO:0035860 name: glial cell-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:yaf, PMID:12953054] synonym: "GDNF receptor signaling pathway" EXACT [GOC:yaf] synonym: "glial cell derived neurotrophic factor receptor signaling pathway" EXACT [GOC:bf] synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:yaf] synonym: "glial cell-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway created_by: rfoulger creation_date: 2011-05-17T11:01:33Z [Term] id: GO:0035861 name: site of double-strand break namespace: cellular_component def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] synonym: "DNA damage foci" RELATED [GOC:vw] synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408] synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408] synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408] synonym: "site of DSB" EXACT [PMID:21035408] is_a: GO:0090734 ! site of DNA damage created_by: rfoulger creation_date: 2011-05-17T03:04:42Z [Term] id: GO:0035862 name: dITP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:bf] synonym: "2'-Deoxyinosine 5'-triphosphate metabolic process" EXACT [] synonym: "2'-Deoxyinosine-5'-triphosphate metabolic process" EXACT [] synonym: "deoxyinosine 5'-triphosphate metabolic process" EXACT [] synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process" EXACT [GOC:dgf] synonym: "dITP metabolism" EXACT [GOC:bf] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process created_by: rfoulger creation_date: 2011-05-25T02:52:58Z [Term] id: GO:0035863 name: dITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:dgf] synonym: "2'-Deoxyinosine 5'-triphosphate catabolic process" EXACT [] synonym: "2'-Deoxyinosine-5'-triphosphate catabolic process" EXACT [] synonym: "deoxyinosine 5'-triphosphate catabolic process" EXACT [] synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process" EXACT [GOC:dgf] synonym: "dITP breakdown" EXACT [GOC:bf] synonym: "dITP catabolism" EXACT [GOC:bf] synonym: "dITP degradation" EXACT [GOC:bf] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0035862 ! dITP metabolic process created_by: rfoulger creation_date: 2011-05-25T02:55:21Z [Term] id: GO:0035864 name: response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "response to K+ ion" EXACT [GOC:bf] synonym: "response to potassium" EXACT [GOC:bf] is_a: GO:0010038 ! response to metal ion created_by: rfoulger creation_date: 2011-05-25T02:58:45Z [Term] id: GO:0035865 name: cellular response to potassium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] synonym: "cellular response to K+ ion" EXACT [GOC:bf] synonym: "cellular response to potassium" EXACT [GOC:bf] is_a: GO:0035864 ! response to potassium ion is_a: GO:0071248 ! cellular response to metal ion created_by: rfoulger creation_date: 2011-05-25T02:59:11Z [Term] id: GO:0035866 name: alphav-beta3 integrin-PKCalpha complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha." [GOC:BHF, GOC:ebc, PMID:16014375] synonym: "alphav-beta3 integrin-PKCa complex" EXACT [GOC:ebc] synonym: "alphav-beta3 integrin-protein kinase C alpha complex" EXACT [GOC:bf] is_a: GO:0098797 ! plasma membrane protein complex created_by: rfoulger creation_date: 2011-05-25T03:03:59Z [Term] id: GO:0035867 name: alphav-beta3 integrin-IGF-1-IGF1R complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits." [GOC:BHF, GOC:ebc, PMID:19578119] is_a: GO:0098797 ! plasma membrane protein complex created_by: rfoulger creation_date: 2011-05-25T03:06:30Z [Term] id: GO:0035868 name: alphav-beta3 integrin-HMGB1 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein." [GOC:BHF, GOC:ebc, PMID:20826760] synonym: "alphav-beta3 integrin-high mobility group box 1 complex" EXACT [GOC:bf] synonym: "alphaV-beta3 integrin-HMGB1 complex" EXACT [GOC:ebc] is_a: GO:0098797 ! plasma membrane protein complex created_by: rfoulger creation_date: 2011-05-25T03:07:24Z [Term] id: GO:0035869 name: ciliary transition zone namespace: cellular_component def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230] comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. synonym: "cilial transition zone" EXACT [] synonym: "cilium transition zone" EXACT [] synonym: "connecting cilium" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium created_by: rfoulger creation_date: 2011-05-25T03:09:58Z [Term] id: GO:0035870 name: dITP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dITP + H2O = dIMP + diphosphate." [EC:3.6.1.-, GOC:dgf, PMID:21548881, RHEA:28342] synonym: "2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R03531] synonym: "deoxyinosine triphosphate pyrophosphatase activity" EXACT [GOC:bf] synonym: "dITP pyrophosphatase activity" EXACT [GOC:bf] xref: EC:3.6.1 xref: KEGG_REACTION:R03531 xref: MetaCyc:RXN0-1602 xref: Reactome:R-HSA-2509838 "ITPA hydrolyses dITP to dIMP" xref: RHEA:28342 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2011-05-26T11:32:26Z [Term] id: GO:0035871 name: protein K11-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein." [GOC:sp, PMID:21596315] synonym: "protein K11-linked deubiquitinylation" EXACT [GOC:bf] synonym: "protein K11-linked deubiquitylation" EXACT [GOC:bf] is_a: GO:0016579 ! protein deubiquitination created_by: rfoulger creation_date: 2011-05-26T11:44:13Z [Term] id: GO:0035872 name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process." [GOC:sj, PMID:18280719, Reactome:168643] synonym: "NLR signaling pathway" EXACT [PMID:18280719] synonym: "NOD-like receptor signaling pathway" RELATED [Wikipedia:NOD-like_receptor] synonym: "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT [PMID:18280719] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT [GOC:bf] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT [GOC:bf] synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0030522 ! intracellular receptor signaling pathway created_by: rfoulger creation_date: 2011-05-26T03:30:36Z [Term] id: GO:0035873 name: lactate transmembrane transport namespace: biological_process def: "The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:mcc, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "lactate membrane transport" EXACT [] is_a: GO:0015727 ! lactate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: rfoulger creation_date: 2011-05-31T09:26:59Z [Term] id: GO:0035874 name: cellular response to copper ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469] synonym: "cellular response to copper starvation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0120126 ! response to copper ion starvation created_by: rfoulger creation_date: 2011-05-31T09:28:47Z [Term] id: GO:0035875 name: maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] synonym: "maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] synonym: "maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:bf] synonym: "maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:bf] is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: part_of GO:0051754 ! meiotic sister chromatid cohesion, centromeric created_by: rfoulger creation_date: 2011-05-31T09:35:51Z [Term] id: GO:0035876 name: maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] synonym: "maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:bf] synonym: "maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:bf] is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion relationship: part_of GO:0051760 ! meiotic sister chromatid cohesion, arms created_by: rfoulger creation_date: 2011-05-31T09:37:53Z [Term] id: GO:0035877 name: death effector domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)." [GOC:ecd, InterPro:IPR001875] comment: For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'. synonym: "DED binding" EXACT [InterPro:IPR001875] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2011-05-31T09:40:46Z [Term] id: GO:0035878 name: nail development namespace: biological_process def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060173 ! limb development created_by: rfoulger creation_date: 2011-05-31T02:30:34Z [Term] id: GO:0035879 name: plasma membrane lactate transport namespace: biological_process def: "The directed movement of lactate across a plasma membrane." [GOC:mcc] synonym: "lactate plasma membrane transport" EXACT [GOC:bf] is_a: GO:0035873 ! lactate transmembrane transport created_by: rfoulger creation_date: 2011-05-31T02:54:32Z [Term] id: GO:0035880 name: embryonic nail plate morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits." [GOC:BHF, GOC:vk, ISBN:0323025781, PMID:11369996, UBERON:0008198, Wikipedia:Nail_(anatomy)] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0035878 ! nail development relationship: part_of GO:0042733 ! embryonic digit morphogenesis created_by: rfoulger creation_date: 2011-05-31T02:38:57Z [Term] id: GO:0035881 name: amacrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf] synonym: "amacrine neuron differentiation" EXACT [CL:0000561] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003407 ! neural retina development created_by: rfoulger creation_date: 2011-06-06T11:32:50Z [Term] id: GO:0035882 name: defecation rhythm namespace: biological_process def: "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated." [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270] synonym: "defecation behavior" RELATED [PMID:7479775, PMID:9066270] synonym: "defecation cycle" EXACT [PMID:8158250] synonym: "defecation motor program" EXACT [GOC:kmv, PMID:9066270] synonym: "DMP" EXACT [PMID:9066270] is_a: GO:0007624 ! ultradian rhythm relationship: part_of GO:0030421 ! defecation created_by: rfoulger creation_date: 2011-06-06T11:36:35Z [Term] id: GO:0035883 name: enteroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] is_a: GO:0002067 ! glandular epithelial cell differentiation created_by: rfoulger creation_date: 2011-06-06T11:48:51Z [Term] id: GO:0035884 name: arabinan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues." [GOC:rs, ISBN:0198506732] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0031221 ! arabinan metabolic process created_by: rfoulger creation_date: 2011-06-08T11:01:14Z [Term] id: GO:0035885 name: exochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509] xref: MetaCyc:RXN-12309 is_a: GO:0004568 ! chitinase activity created_by: rfoulger creation_date: 2011-06-08T11:13:58Z [Term] id: GO:0035886 name: vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular associated smooth muscle cell differentiation" EXACT [CL:0000359] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0001944 ! vasculature development created_by: rfoulger creation_date: 2011-06-08T11:23:52Z [Term] id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] is_a: GO:0035886 ! vascular smooth muscle cell differentiation created_by: rfoulger creation_date: 2011-06-08T11:34:26Z [Term] id: GO:0035888 name: isoguanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: isoguanine + H2O = xanthine + NH3." [EC:3.5.4.-, GOC:imk, PMID:21604715] synonym: "2-hydroxyadenine deaminase activity" EXACT [PMID:14709079, PMID:8841637] synonym: "2-oxoadenine deaminase activity" EXACT [PMID:14709079] is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity created_by: rfoulger creation_date: 2011-06-14T02:15:53Z [Term] id: GO:0035889 name: otolith tethering namespace: biological_process def: "The attachment of a developing otolith to the kinocilia of tether cells in the inner ear." [GOC:dgh, PMID:14499652] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0048840 ! otolith development created_by: rfoulger creation_date: 2011-06-14T02:28:14Z [Term] id: GO:0035890 name: exit from host namespace: biological_process def: "The directed movement of an organism out of the body, tissues or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf] synonym: "ejection from host" RELATED [GOC:bf] is_a: GO:0052126 ! movement in host environment created_by: rfoulger creation_date: 2011-06-15T02:08:03Z [Term] id: GO:0035891 name: exit from host cell namespace: biological_process def: "The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:rs, PMID:19325115] synonym: "ejection from host cell" RELATED [PMID:19325115] synonym: "host cell exit" EXACT [PMID:19325115] is_a: GO:0035890 ! exit from host created_by: rfoulger creation_date: 2011-06-15T02:09:28Z [Term] id: GO:0035892 name: modulation of platelet aggregation in other organism namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:bf, GOC:fj, PMID:15922770] synonym: "modulation by organism of platelet aggregation in other organism" EXACT [GOC:bf] synonym: "regulation of platelet aggregation in other organism" RELATED [GOC:bf] is_a: GO:0035806 ! modulation of blood coagulation in other organism is_a: GO:0044364 ! disruption of cells of other organism is_a: GO:0090330 ! regulation of platelet aggregation created_by: rfoulger creation_date: 2011-06-15T02:21:10Z [Term] id: GO:0035893 name: negative regulation of platelet aggregation in other organism namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism." [GOC:bf, GOC:fj, PMID:15922770] synonym: "down-regulation of platelet aggregation in other organism" EXACT [GOC:bf] synonym: "downregulation of platelet aggregation in other organism" EXACT [GOC:bf] synonym: "inhibition of platelet aggregation in other organism" EXACT [GOC:bf] synonym: "suppression of platelet aggregation in other organism" EXACT [GOC:bf] is_a: GO:0035892 ! modulation of platelet aggregation in other organism is_a: GO:0035899 ! negative regulation of blood coagulation in other organism is_a: GO:0090331 ! negative regulation of platelet aggregation created_by: rfoulger creation_date: 2011-06-15T02:24:43Z [Term] id: GO:0035894 name: positive regulation of platelet aggregation in other organism namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism." [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547] synonym: "up-regulation of platelet aggregation in other organism" RELATED [GOC:bf] synonym: "upregulation of platelet aggregation in other organism" EXACT [GOC:bf] is_a: GO:0035807 ! positive regulation of blood coagulation in other organism is_a: GO:0035892 ! modulation of platelet aggregation in other organism is_a: GO:1901731 ! positive regulation of platelet aggregation created_by: rfoulger creation_date: 2011-06-15T02:28:46Z [Term] id: GO:0035895 name: modulation of mast cell degranulation in other organism namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [GOC:bf, GOC:fj, PMID:21549739] synonym: "regulation of mast cell degranulation in other organism" EXACT [GOC:bf] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:0043304 ! regulation of mast cell degranulation created_by: rfoulger creation_date: 2011-06-15T02:46:50Z [Term] id: GO:0035896 name: positive regulation of mast cell degranulation in other organism namespace: biological_process def: "Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism." [GOC:bf, GOC:fj] synonym: "up-regulation of mast cell degranulation in other organism" RELATED [GOC:bf] synonym: "upregulation of mast cell degranulation in other organism" EXACT [GOC:bf] is_a: GO:0035895 ! modulation of mast cell degranulation in other organism is_a: GO:0043306 ! positive regulation of mast cell degranulation created_by: rfoulger creation_date: 2011-06-15T02:49:03Z [Term] id: GO:0035897 name: proteolysis in other organism namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds." [GOC:bf, GOC:fj, PMID:15922779] is_a: GO:0006508 ! proteolysis is_a: GO:0044033 ! multi-organism metabolic process created_by: rfoulger creation_date: 2011-06-15T03:00:27Z [Term] id: GO:0035898 name: parathyroid hormone secretion namespace: biological_process def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021, PR:000013429] synonym: "parathormone secretion" EXACT [PR:000013429] synonym: "parathyrin secretion" EXACT [PR:000013429] synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429] is_a: GO:0060986 ! endocrine hormone secretion created_by: rfoulger creation_date: 2011-06-22T09:28:54Z [Term] id: GO:0035899 name: negative regulation of blood coagulation in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:fj] synonym: "down-regulation of blood coagulation in other organism" EXACT [GOC:bf] synonym: "downregulation of blood coagulation in other organism" EXACT [GOC:bf] synonym: "inhibition of blood coagulation in other organism" NARROW [GOC:bf] synonym: "negative regulation of blood clotting in other organism" EXACT [GOC:bf] synonym: "suppression of blood coagulation in other organism" EXACT [GOC:bf] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0035806 ! modulation of blood coagulation in other organism created_by: rfoulger creation_date: 2011-06-22T09:17:54Z [Term] id: GO:0035900 name: response to isolation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532] synonym: "response to social isolation" EXACT [PMID:20203532] is_a: GO:0006950 ! response to stress created_by: rfoulger creation_date: 2011-06-22T09:39:57Z [Term] id: GO:0035901 name: cellular response to isolation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532] synonym: "cellular response to social isolation" EXACT [PMID:20203532] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035900 ! response to isolation stress created_by: rfoulger creation_date: 2011-06-22T09:43:34Z [Term] id: GO:0035902 name: response to immobilization stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991] synonym: "response to immobilisation stress" EXACT [GOC:bf] synonym: "response to restraint stress" RELATED [GOC:sl] is_a: GO:0006950 ! response to stress created_by: rfoulger creation_date: 2011-06-22T09:45:50Z [Term] id: GO:0035903 name: cellular response to immobilization stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991] synonym: "cellular response to immobilisation stress" EXACT [GOC:bf] synonym: "cellular response to restraint stress" RELATED [GOC:sl] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035902 ! response to immobilization stress created_by: rfoulger creation_date: 2011-06-22T09:47:44Z [Term] id: GO:0035904 name: aorta development namespace: biological_process def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0060840 ! artery development created_by: rfoulger creation_date: 2011-06-24T11:00:07Z [Term] id: GO:0035905 name: ascending aorta development namespace: biological_process def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035904 ! aorta development created_by: rfoulger creation_date: 2011-06-24T11:02:01Z [Term] id: GO:0035906 name: descending aorta development namespace: biological_process def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035904 ! aorta development created_by: rfoulger creation_date: 2011-06-24T11:05:22Z [Term] id: GO:0035907 name: dorsal aorta development namespace: biological_process def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035904 ! aorta development created_by: rfoulger creation_date: 2011-06-24T11:07:01Z [Term] id: GO:0035908 name: ventral aorta development namespace: biological_process def: "The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604] is_a: GO:0035904 ! aorta development created_by: rfoulger creation_date: 2011-06-24T11:08:49Z [Term] id: GO:0035909 name: aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0048844 ! artery morphogenesis relationship: part_of GO:0035904 ! aorta development created_by: rfoulger creation_date: 2011-06-24T11:11:11Z [Term] id: GO:0035910 name: ascending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035905 ! ascending aorta development relationship: part_of GO:0035909 ! aorta morphogenesis created_by: rfoulger creation_date: 2011-06-24T11:14:52Z [Term] id: GO:0035911 name: descending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035906 ! descending aorta development relationship: part_of GO:0035909 ! aorta morphogenesis created_by: rfoulger creation_date: 2011-06-24T11:19:24Z [Term] id: GO:0035912 name: dorsal aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035909 ! aorta morphogenesis relationship: part_of GO:0035907 ! dorsal aorta development created_by: rfoulger creation_date: 2011-06-24T11:22:14Z [Term] id: GO:0035913 name: ventral aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604] is_a: GO:0035909 ! aorta morphogenesis relationship: part_of GO:0035908 ! ventral aorta development created_by: rfoulger creation_date: 2011-06-24T11:24:36Z [Term] id: GO:0035914 name: skeletal muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007519 ! skeletal muscle tissue development created_by: rfoulger creation_date: 2011-06-24T02:36:19Z [Term] id: GO:0035915 name: pore formation in membrane of other organism namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism." [GOC:bf, GOC:fj, PMID:21549739] synonym: "pore biosynthesis in other organism" EXACT [GOC:bf] synonym: "pore complex assembly in other organism" EXACT [] synonym: "pore complex biogenesis in other organism" EXACT [GOC:bf] synonym: "pore formation in other organism" EXACT [GOC:bf] synonym: "pore-forming toxin activity" RELATED [GOC:bf] is_a: GO:0051673 ! membrane disruption in other organism created_by: rfoulger creation_date: 2011-07-01T11:45:01Z [Term] id: GO:0035916 name: modulation of calcium channel activity in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515] is_a: GO:0044561 ! modulation of ion channel activity in other organism created_by: rfoulger creation_date: 2011-07-01T11:51:38Z [Term] id: GO:0035917 name: negative regulation of calcium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515] synonym: "down-regulation of calcium channel activity in other organism" EXACT [GOC:bf] synonym: "downregulation of calcium channel activity in other organism" EXACT [GOC:bf] synonym: "inhibition of calcium channel activity in other organism" NARROW [GOC:bf] is_a: GO:0035916 ! modulation of calcium channel activity in other organism is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction created_by: rfoulger creation_date: 2011-07-01T11:52:55Z [Term] id: GO:0035918 name: negative regulation of voltage-gated calcium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] synonym: "down-regulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "downregulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "inhibition of voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] synonym: "negative regulation of voltage gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "negative regulation of voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] synonym: "negative regulation of voltage-sensitive calcium channel activity in other organism" EXACT [GOC:bf] is_a: GO:0035917 ! negative regulation of calcium channel activity in other organism created_by: rfoulger creation_date: 2011-07-01T11:54:43Z [Term] id: GO:0035919 name: negative regulation of low voltage-gated calcium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] synonym: "down-regulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "downregulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "inhibition of low voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] synonym: "negative regulation of low voltage gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "negative regulation of low voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism created_by: rfoulger creation_date: 2011-07-01T11:56:21Z [Term] id: GO:0035920 name: negative regulation of high voltage-gated calcium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] synonym: "down-regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "downregulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "inhibition of high voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] synonym: "negative regulation of high voltage gated calcium channel activity in other organism" EXACT [GOC:bf] synonym: "negative regulation of high voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism created_by: rfoulger creation_date: 2011-07-01T12:00:23Z [Term] id: GO:0035921 name: desmosome disassembly namespace: biological_process def: "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671] synonym: "desmosome dissociation" EXACT [PMID:9182671] is_a: GO:0002934 ! desmosome organization is_a: GO:0150147 ! cell-cell junction disassembly created_by: rfoulger creation_date: 2011-07-05T01:33:25Z [Term] id: GO:0035922 name: foramen ovale closure namespace: biological_process def: "The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow." [GOC:BHF, GOC:vk, PMID:19762328, UBERON:0004754, Wikipedia:Foramen_ovale_(heart)] synonym: "foramen ovale of heart closure" EXACT [UBERON:0004754] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060411 ! cardiac septum morphogenesis created_by: rfoulger creation_date: 2011-07-05T01:39:54Z [Term] id: GO:0035923 name: flurbiprofen binding namespace: molecular_function def: "Interacting selectively and non-covalently with flurbiprofen." [GOC:BHF, GOC:rl] synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding created_by: rfoulger creation_date: 2011-07-15T03:53:53Z [Term] id: GO:0035924 name: cellular response to vascular endothelial growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, PMID:18440775] synonym: "cellular response to vascular endothelial growth factor" EXACT [GOC:rl] synonym: "cellular response to VEGF" EXACT [GOC:rl] synonym: "cellular response to VEGFA" NARROW [GOC:rl] synonym: "cellular response to VEGFB" NARROW [GOC:rl] is_a: GO:0071363 ! cellular response to growth factor stimulus created_by: rfoulger creation_date: 2011-07-15T04:03:29Z [Term] id: GO:0035925 name: mRNA 3'-UTR AU-rich region binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule." [GOC:vw] synonym: "mRNA 3'-UTR adenylate/uridylate-rich element binding" EXACT [PMID:8578590] is_a: GO:0003730 ! mRNA 3'-UTR binding is_a: GO:0017091 ! AU-rich element binding created_by: rfoulger creation_date: 2011-07-19T09:30:18Z [Term] id: GO:0035926 name: chemokine (C-C motif) ligand 2 secretion namespace: biological_process def: "The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell." [PMID:21501162] synonym: "CCL2 secretion" EXACT [GOC:bf] is_a: GO:0090195 ! chemokine secretion relationship: part_of GO:0072567 ! chemokine (C-X-C motif) ligand 2 production created_by: rfoulger creation_date: 2011-07-19T09:33:54Z [Term] id: GO:0035927 name: RNA import into mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol, into the mitochondrial matrix." [GOC:ans, PMID:20691904] synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans] synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0050658 ! RNA transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: rfoulger creation_date: 2011-07-19T09:39:37Z [Term] id: GO:0035928 name: rRNA import into mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol, into the mitochondrial matrix." [GOC:ans, PMID:20691904] synonym: "cytoplasmic rRNA import into mitochondrion" NARROW [GOC:ans] synonym: "nuclear-encoded rRNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0035927 ! RNA import into mitochondrion is_a: GO:0051029 ! rRNA transport created_by: rfoulger creation_date: 2011-07-19T09:41:42Z [Term] id: GO:0035929 name: steroid hormone secretion namespace: biological_process def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl] is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-20T01:01:00Z [Term] id: GO:0035930 name: corticosteroid hormone secretion namespace: biological_process def: "The regulated release of any corticosteroid hormone into the circulatory system." [GOC:sl] synonym: "corticosteroid secretion" BROAD [GOC:bf] is_a: GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-20T01:03:22Z [Term] id: GO:0035931 name: mineralocorticoid secretion namespace: biological_process def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [GOC:sl] is_a: GO:0035930 ! corticosteroid hormone secretion created_by: rfoulger creation_date: 2011-07-20T01:04:59Z [Term] id: GO:0035932 name: aldosterone secretion namespace: biological_process def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [GOC:sl] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035931 ! mineralocorticoid secretion created_by: rfoulger creation_date: 2011-07-20T01:06:24Z [Term] id: GO:0035933 name: glucocorticoid secretion namespace: biological_process def: "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." [GOC:sl] is_a: GO:0035930 ! corticosteroid hormone secretion created_by: rfoulger creation_date: 2011-07-20T01:08:37Z [Term] id: GO:0035934 name: corticosterone secretion namespace: biological_process def: "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands." [GOC:sl] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0035933 ! glucocorticoid secretion created_by: rfoulger creation_date: 2011-07-20T01:09:31Z [Term] id: GO:0035935 name: androgen secretion namespace: biological_process def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl] is_a: GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-20T01:11:31Z [Term] id: GO:0035936 name: testosterone secretion namespace: biological_process def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [GOC:sl, PMID:12606499] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-20T01:13:13Z [Term] id: GO:0035937 name: estrogen secretion namespace: biological_process def: "The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals." [GOC:sl] synonym: "oestrogen secretion" RELATED [] is_a: GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-20T01:14:44Z [Term] id: GO:0035938 name: estradiol secretion namespace: biological_process def: "The regulated release of estradiol into the circulatory system." [GOC:sl, PMID:21632818] synonym: "oestradiol secretion" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-20T01:16:45Z [Term] id: GO:0035939 name: microsatellite binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem." [GOC:yaf, PMID:21290414, SO:0000289] synonym: "microsatellite DNA binding" EXACT [GOC:bf] synonym: "variable number tandem repeat binding" EXACT [PMID:21290414] synonym: "VNTR binding" EXACT [SO:0000289] is_a: GO:0003696 ! satellite DNA binding created_by: rfoulger creation_date: 2011-07-20T01:26:26Z [Term] id: GO:0035940 name: negative regulation of peptidase activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism." [GOC:klp, PMID:10595640] synonym: "down regulation of peptidase activity in other organism" EXACT [GOC:bf] synonym: "down-regulation of protease activity in other organism" NARROW [GOC:bf] synonym: "downregulation of peptidase activity in other organism" EXACT [GOC:bf] synonym: "inhibition of protease activity in other organism" NARROW [GOC:bf] synonym: "negative regulation of protease activity in other organism" NARROW [GOC:bf] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0044362 ! negative regulation of molecular function in other organism created_by: rfoulger creation_date: 2011-07-22T02:59:40Z [Term] id: GO:0035941 name: androstenedione secretion namespace: biological_process def: "The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system." [GOC:sl] synonym: "androst-4-ene-3,17-dione secretion" EXACT [] is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-25T02:11:47Z [Term] id: GO:0035942 name: dehydroepiandrosterone secretion namespace: biological_process def: "The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system." [GOC:sl] synonym: "3beta-hydroxyandrost-5-en-17-one secretion" EXACT [] synonym: "dehydroisoandrosterone secretion" EXACT [] synonym: "DHEA secretion" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-25T02:13:54Z [Term] id: GO:0035943 name: estrone secretion namespace: biological_process def: "The regulated release of estrone into the circulatory system." [GOC:sl, PMID:8395854] synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [] synonym: "folliculin secretion" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: rfoulger creation_date: 2011-07-25T02:18:40Z [Term] id: GO:0035944 name: perforin production namespace: biological_process def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000003466] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: rfoulger creation_date: 2011-07-27T11:44:21Z [Term] id: GO:0035945 name: mitochondrial ncRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion." [GOC:ans, PMID:19864255] synonym: "mitochondrial aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "mitochondrial ncRNA quality control" EXACT [GOC:dgf, GOC:krc] synonym: "mitochondrial non-coding RNA surveillance" EXACT [GOC:bf] is_a: GO:2000827 ! mitochondrial RNA surveillance created_by: rfoulger creation_date: 2011-07-28T10:34:59Z [Term] id: GO:0035946 name: mitochondrial mRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion." [GOC:ans, PMID:19864255] synonym: "mitochondrial aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "mitochondrial messenger RNA surveillance" EXACT [GOC:bf] synonym: "mitochondrial mRNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:2000827 ! mitochondrial RNA surveillance created_by: rfoulger creation_date: 2011-07-28T10:37:07Z [Term] id: GO:0035947 name: regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] synonym: "regulation of gluconeogenesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: regulates GO:0006094 ! gluconeogenesis created_by: rfoulger [Term] id: GO:0035948 name: positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938] synonym: "regulation of gluconeogenesis by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of gluconeogenesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of gluconeogenesis by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of gluconeogenesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of gluconeogenesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of gluconeogenesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "regulation of glucose biosynthetic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glucose biosynthetic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035947 ! regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter is_a: GO:0045722 ! positive regulation of gluconeogenesis is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006094 ! gluconeogenesis created_by: rfoulger [Term] id: GO:0035949 name: positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938] synonym: "positive regulation of gluconeogenesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of gluconeogenesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of gluconeogenesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of gluconeogenesis by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] synonym: "positive regulation of gluconeogenesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of glucose biosynthetic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthetic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthetic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0035947 ! regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter is_a: GO:0045722 ! positive regulation of gluconeogenesis intersection_of: GO:0045722 ! positive regulation of gluconeogenesis intersection_of: negatively_regulates GO:0006366 ! transcription by RNA polymerase II created_by: rfoulger [Term] id: GO:0035950 name: regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] synonym: "regulation of oligopeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0090088 ! regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006857 ! oligopeptide transport created_by: rfoulger [Term] id: GO:0035951 name: positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] synonym: "positive regulation of oligopeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of oligopeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of oligopeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of oligopeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of oligopeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of oligopeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:2000878 ! positive regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0006857 ! oligopeptide transport created_by: rfoulger [Term] id: GO:0035952 name: negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] synonym: "negative regulation of oligopeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of oligopeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of oligopeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of oligopeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] synonym: "negative regulation of oligopeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter is_a: GO:2000877 ! negative regulation of oligopeptide transport intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0006857 ! oligopeptide transport created_by: rfoulger [Term] id: GO:0035953 name: regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] synonym: "regulation of dipeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol] is_a: GO:0035950 ! regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter is_a: GO:0090089 ! regulation of dipeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0042938 ! dipeptide transport created_by: rfoulger [Term] id: GO:0035954 name: positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] synonym: "positive regulation of dipeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of dipeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of dipeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of dipeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of dipeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of dipeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035951 ! positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter is_a: GO:0035953 ! regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter is_a: GO:2000880 ! positive regulation of dipeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0042938 ! dipeptide transport created_by: rfoulger [Term] id: GO:0035955 name: negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:10850718, PMID:17005992, PMID:9427760] synonym: "negative regulation of dipeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of dipeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of dipeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of dipeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] synonym: "negative regulation of dipeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] is_a: GO:0035952 ! negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter is_a: GO:0035953 ! regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter is_a: GO:2000879 ! negative regulation of dipeptide transport intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0042938 ! dipeptide transport created_by: rfoulger [Term] id: GO:0035956 name: regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9342405] synonym: "regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GGOC:obol] synonym: "regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:2000881 ! regulation of starch catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005983 ! starch catabolic process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II created_by: rfoulger [Term] id: GO:0035957 name: obsolete positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "positive regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] is_obsolete: true created_by: rfoulger [Term] id: GO:0035958 name: obsolete regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of glyoxylate bypass by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of glyoxylate bypass by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "regulation of glyoxylate cycle by regulation of transcription from Pol II promoter" RELATED [GOC:obol] is_obsolete: true created_by: rfoulger [Term] id: GO:0035959 name: obsolete positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate bypass by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate bypass by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate bypass by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of glyoxylate cycle by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_obsolete: true created_by: rfoulger [Term] id: GO:0035960 name: regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229, PMID:16055745] synonym: "regulation of ergosterol anabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of ergosterol anabolism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "regulation of ergosterol biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of ergosterol biosynthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "regulation of ergosterol biosynthetic process by regulation of transcription from Pol II promoter" RELATED [GOC:obol] synonym: "regulation of ergosterol formation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of ergosterol formation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "regulation of ergosterol synthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of ergosterol synthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0032443 ! regulation of ergosterol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006696 ! ergosterol biosynthetic process created_by: rfoulger [Term] id: GO:0035961 name: positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229] synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol anabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol anabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol anabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by activation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by positive regulation of transcription from Pol II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by stimulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by up regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol biosynthetic process by upregulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol formation by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol formation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol formation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol formation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol formation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] synonym: "positive regulation of ergosterol synthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol synthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of ergosterol synthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035960 ! regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0070452 ! positive regulation of ergosterol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0006696 ! ergosterol biosynthetic process created_by: rfoulger [Term] id: GO:0035962 name: response to interleukin-13 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461] synonym: "response to IL-13" EXACT [GOC:bf] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2011-08-01T11:29:02Z [Term] id: GO:0035963 name: cellular response to interleukin-13 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461] synonym: "cellular response to IL-13" EXACT [GOC:bf] is_a: GO:0035962 ! response to interleukin-13 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2011-08-01T11:29:42Z [Term] id: GO:0035964 name: COPI-coated vesicle budding namespace: biological_process def: "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle." [GOC:br, PMID:10052452, PMID:17041781] synonym: "COPI vesicle budding" EXACT [PMID:17041781] is_a: GO:0048194 ! Golgi vesicle budding relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi created_by: rfoulger creation_date: 2011-08-01T11:32:23Z [Term] id: GO:0035965 name: cardiolipin acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids." [GOC:bf, GOC:rb, PMID:19244244] synonym: "cardiolipin acyl-chain remodelling" EXACT [GOC:bf] synonym: "cardiolipin maturation" BROAD [GOC:rb] synonym: "diphosphatidylglycerol remodeling" RELATED [] is_a: GO:0032048 ! cardiolipin metabolic process created_by: rfoulger creation_date: 2011-08-03T11:17:49Z [Term] id: GO:0035966 name: response to topologically incorrect protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] synonym: "response to misfolded or unfolded protein" RELATED [GOC:bf] is_a: GO:0006950 ! response to stress is_a: GO:0010033 ! response to organic substance created_by: rfoulger creation_date: 2011-08-03T11:43:12Z [Term] id: GO:0035967 name: cellular response to topologically incorrect protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] synonym: "cellular response to misfolded or unfolded protein" RELATED [GOC:bf] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035966 ! response to topologically incorrect protein is_a: GO:0071310 ! cellular response to organic substance created_by: rfoulger creation_date: 2011-08-03T11:44:50Z [Term] id: GO:0035968 name: regulation of sterol import by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:12077145] synonym: "regulation of sterol import by regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "regulation of sterol influx by regulation of transcription from Pol II promoter" EXACT [GOC:bf] synonym: "regulation of sterol influx by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] synonym: "regulation of sterol uptake by regulation of transcription from Pol II promoter" EXACT [GOC:bf] synonym: "regulation of sterol uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter is_a: GO:2000909 ! regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0035376 ! sterol import created_by: rfoulger [Term] id: GO:0035969 name: positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229] synonym: "positive regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol import by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035968 ! regulation of sterol import by regulation of transcription from RNA polymerase II promoter is_a: GO:0072369 ! regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter is_a: GO:2000911 ! positive regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0035376 ! sterol import created_by: rfoulger [Term] id: GO:0035970 name: peptidyl-threonine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf] is_a: GO:0006470 ! protein dephosphorylation created_by: rfoulger creation_date: 2011-08-08T02:57:11Z [Term] id: GO:0035971 name: peptidyl-histidine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine." [GOC:BHF, GOC:vk, PMID:12383260] is_a: GO:0006470 ! protein dephosphorylation created_by: rfoulger creation_date: 2011-08-08T03:26:02Z [Term] id: GO:0035973 name: aggrephagy namespace: biological_process alt_id: GO:0035972 def: "Selective degradation of protein aggregates by macroautophagy." [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811] is_a: GO:0061912 ! selective autophagy created_by: rfoulger creation_date: 2011-08-09T09:53:40Z [Term] id: GO:0035974 name: meiotic spindle pole body namespace: cellular_component def: "The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:vw, PMID:21775631] is_a: GO:0005816 ! spindle pole body created_by: rfoulger creation_date: 2011-08-16T11:37:59Z [Term] id: GO:0035975 name: carbamoyl phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [GOC:yaf, UniPathway:UPA00996] synonym: "carbamoyl phosphate breakdown" EXACT [GOC:bf] synonym: "carbamoyl phosphate catabolism" EXACT [GOC:bf] synonym: "carbamoyl phosphate degradation" EXACT [GOC:bf] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0070408 ! carbamoyl phosphate metabolic process created_by: rfoulger creation_date: 2011-08-16T11:41:13Z [Term] id: GO:0035976 name: transcription factor AP-1 complex namespace: cellular_component def: "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes." [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor] synonym: "Activating protein 1 complex" EXACT [GOC:rl] synonym: "AP-1 complex" EXACT [GOC:rl] synonym: "AP1 complex" EXACT [GOC:rl] synonym: "transcription factor AP1 complex" EXACT [GOC:rl] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: rfoulger creation_date: 2011-08-17T10:57:51Z [Term] id: GO:0035977 name: protein deglycosylation involved in glycoprotein catabolic process namespace: biological_process def: "The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein." [GOC:bf, GOC:vw] is_a: GO:0006517 ! protein deglycosylation intersection_of: GO:0006517 ! protein deglycosylation intersection_of: part_of GO:0006516 ! glycoprotein catabolic process relationship: part_of GO:0006516 ! glycoprotein catabolic process created_by: rfoulger creation_date: 2011-08-18T10:31:23Z [Term] id: GO:0035978 name: histone H2A-S139 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone." [GOC:yaf, PMID:16061642] comment: Residue 1 of histone H2AX is taken as the first residue following removal of the initiating Methionine (Met). synonym: "histone H2A.x phosphorylation at S139" NARROW [GOC:bf, PMID:16061642] is_a: GO:0035404 ! histone-serine phosphorylation is_a: GO:1990164 ! histone H2A phosphorylation created_by: rfoulger creation_date: 2011-08-22T11:34:09Z [Term] id: GO:0035979 name: histone kinase activity (H2A-S139 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A." [GOC:yaf, PMID:16061642] comment: Residue 1 of histone H2A is taken as the first residue following removal of the initiating Methionine (Met). synonym: "histone kinase activity (H2A.x-S139 specific)" NARROW [GOC:bf, PMID:16061642] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0035978 ! histone H2A-S139 phosphorylation created_by: rfoulger creation_date: 2011-08-22T01:13:34Z [Term] id: GO:0035980 name: obsolete invasive growth in response to nitrogen limitation namespace: biological_process def: "OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen." [GOC:vw] comment: This term was made obsolete because the GO term 'pseudohyphal growth ; GO:0007124' describes growth under nitrogen-limiting conditions. synonym: "invasive growth in response to nitrogen limitation" EXACT [] is_obsolete: true consider: GO:0007124 created_by: rfoulger creation_date: 2011-08-22T01:20:39Z [Term] id: GO:0035981 name: tongue muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851] is_a: GO:0098528 ! skeletal muscle fiber differentiation created_by: rfoulger creation_date: 2011-08-22T01:35:16Z [Term] id: GO:0035982 name: obsolete age-dependent behavioral decline namespace: biological_process def: "OBSOLETE. A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:kmv, PMID:20523893] comment: This term was made obsolete because it describes a phenotype. synonym: "age-dependent behavioural decline" EXACT [GOC:bf] synonym: "age-related behavioral decline" EXACT [GOC:kmv] synonym: "behavioral aging" EXACT [GOC:kmv] is_obsolete: true replaced_by: GO:0090647 created_by: rfoulger creation_date: 2011-08-23T01:30:55Z [Term] id: GO:0035983 name: response to trichostatin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2011-08-23T01:48:01Z [Term] id: GO:0035984 name: cellular response to trichostatin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743] is_a: GO:0035983 ! response to trichostatin A is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: rfoulger creation_date: 2011-08-23T01:48:43Z [Term] id: GO:0035985 name: senescence-associated heterochromatin focus namespace: cellular_component def: "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468] synonym: "SAHF" EXACT [GOC:yaf] synonym: "senescence-associated heterochromatin foci" EXACT [PMID:15621527, PMID:21248468] is_a: GO:0000792 ! heterochromatin created_by: rfoulger creation_date: 2011-08-25T04:36:40Z [Term] id: GO:0035986 name: senescence-associated heterochromatin focus assembly namespace: biological_process def: "The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468] synonym: "SAHF formation" EXACT [GOC:yaf] synonym: "senescence-associated heterochromatin foci formation" EXACT [GOC:yaf] synonym: "senescence-associated heterochromatin focus formation" EXACT [] is_a: GO:0031507 ! heterochromatin assembly created_by: rfoulger creation_date: 2011-08-25T04:43:56Z [Term] id: GO:0035987 name: endodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332] synonym: "endoderm cell differentiation" EXACT [CL:0000223] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001706 ! endoderm formation created_by: rfoulger creation_date: 2011-08-25T04:50:36Z [Term] id: GO:0035988 name: chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:yaf, PMID:21484705] synonym: "cartilage cell proliferation" EXACT [CL:0000138] synonym: "chondrocyte cell proliferation" EXACT [GOC:bf] is_a: GO:0008283 ! cell population proliferation created_by: rfoulger creation_date: 2011-08-25T04:53:40Z [Term] id: GO:0035989 name: tendon development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043] synonym: "sinew development" RELATED [UBERON:0000043] is_a: GO:0061448 ! connective tissue development created_by: rfoulger creation_date: 2011-08-26T04:14:30Z [Term] id: GO:0035990 name: tendon cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429] synonym: "muscle attachment cell differentiation" EXACT [CL:0000388] synonym: "tenocyte differentiation" RELATED [CL:0000388] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0035992 ! tendon formation created_by: rfoulger creation_date: 2011-08-26T04:16:06Z [Term] id: GO:0035991 name: nitric oxide sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957] synonym: "NO sensor activity" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0070026 ! nitric oxide binding is_a: GO:0140299 ! small molecule sensor activity relationship: part_of GO:0071731 ! response to nitric oxide created_by: rfoulger creation_date: 2011-08-26T04:32:16Z [Term] id: GO:0035992 name: tendon formation namespace: biological_process def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035989 ! tendon development created_by: rfoulger creation_date: 2011-08-30T01:35:10Z [Term] id: GO:0035993 name: deltoid tuberosity development namespace: biological_process def: "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060173 ! limb development relationship: part_of GO:0060348 ! bone development created_by: rfoulger creation_date: 2011-08-30T01:46:53Z [Term] id: GO:0035994 name: response to muscle stretch namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length." [GOC:BHF, GOC:vk, PMID:14583192] is_a: GO:0009612 ! response to mechanical stimulus created_by: rfoulger creation_date: 2011-08-30T01:52:31Z [Term] id: GO:0035995 name: detection of muscle stretch namespace: biological_process def: "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal." [PMID:14583192] is_a: GO:0035994 ! response to muscle stretch is_a: GO:0050982 ! detection of mechanical stimulus created_by: rfoulger creation_date: 2011-08-30T01:53:35Z [Term] id: GO:0035996 name: rhabdomere microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] is_a: GO:0005902 ! microvillus relationship: part_of GO:0016028 ! rhabdomere created_by: rfoulger creation_date: 2011-09-01T02:18:30Z [Term] id: GO:0035997 name: rhabdomere microvillus membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] is_a: GO:0031528 ! microvillus membrane relationship: part_of GO:0033583 ! rhabdomere membrane relationship: part_of GO:0035996 ! rhabdomere microvillus created_by: rfoulger creation_date: 2011-09-01T02:24:20Z [Term] id: GO:0035998 name: 7,8-dihydroneopterin 3'-triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [GOC:yaf, UniPathway:UPA00848] synonym: "7,8-dihydroneopterin 3'-triphosphate anabolism" EXACT [GOC:bf] synonym: "7,8-dihydroneopterin 3'-triphosphate biosynthesis" EXACT [GOC:bf] synonym: "7,8-dihydroneopterin 3'-triphosphate formation" EXACT [GOC:bf] synonym: "7,8-dihydroneopterin 3'-triphosphate synthesis" EXACT [GOC:bf] xref: UniPathway:UPA00848 is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0051066 ! dihydrobiopterin metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process created_by: rfoulger creation_date: 2011-09-02T01:15:35Z [Term] id: GO:0035999 name: tetrahydrofolate interconversion namespace: biological_process def: "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] xref: MetaCyc:PWY-2201 xref: UniPathway:UPA00193 is_a: GO:0006730 ! one-carbon metabolic process is_a: GO:0046653 ! tetrahydrofolate metabolic process created_by: rfoulger creation_date: 2011-09-02T01:35:49Z [Term] id: GO:0036000 name: mucocyst namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion." [GOC:mag, PMID:10723937, PMID:4629881] is_a: GO:0030141 ! secretory granule created_by: rfoulger creation_date: 2011-09-06T01:32:17Z [Term] id: GO:0036001 name: 'de novo' pyridoxal 5'-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components." [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY] synonym: "'de novo' PLP biosynthesis" EXACT [MetaCyc:PYRIDOXSYN-PWY] synonym: "'de novo' pyridoxal 5'-phosphate anabolism" EXACT [GOC:bf] synonym: "'de novo' pyridoxal 5'-phosphate biosynthesis" EXACT [GOC:bf] synonym: "'de novo' pyridoxal 5'-phosphate formation" EXACT [GOC:bf] synonym: "'de novo' pyridoxal 5'-phosphate synthesis" EXACT [GOC:bf] synonym: "'de novo' pyridoxal phosphate biosynthetic process" BROAD [GOC:bf] xref: MetaCyc:PYRIDOXSYN-PWY is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process created_by: rfoulger creation_date: 2011-09-06T02:04:53Z [Term] id: GO:0036002 name: pre-mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120] synonym: "protein-coding primary transcript binding" RELATED [SO:0000120] is_a: GO:0003723 ! RNA binding created_by: rfoulger creation_date: 2011-09-16T10:23:37Z [Term] id: GO:0036003 name: positive regulation of transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc] is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II created_by: rfoulger creation_date: 2011-09-19T03:00:18Z [Term] id: GO:0036004 name: GAF domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GAF domain of a protein." [GOC:yaf, InterPro:IPR003018] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2011-09-20T04:20:42Z [Term] id: GO:0036005 name: response to macrophage colony-stimulating factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666] synonym: "response to M-CSF" EXACT [GOC:bf, PMID:14687666] synonym: "response to macrophage colony-stimulating factor" EXACT [GOC:bf] synonym: "response to macrophage colony-stimulating factor stimulus" EXACT [GOC:dos] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2011-09-20T04:22:03Z [Term] id: GO:0036006 name: cellular response to macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666] synonym: "cellular response to M-CSF stimulus" EXACT [GOC:bf, PMID:14687666] synonym: "cellular response to macrophage colony-stimulating factor" EXACT [GOC:bf] is_a: GO:0036005 ! response to macrophage colony-stimulating factor is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2011-09-20T04:23:19Z [Term] id: GO:0036007 name: scintillon namespace: cellular_component def: "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen." [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: rfoulger creation_date: 2011-09-21T03:04:02Z [Term] id: GO:0036008 name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate." [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY] xref: MetaCyc:SUCUTIL-PWY is_a: GO:0005987 ! sucrose catabolic process is_a: GO:0006002 ! fructose 6-phosphate metabolic process is_a: GO:0051156 ! glucose 6-phosphate metabolic process relationship: has_part GO:0008865 ! fructokinase activity relationship: has_part GO:0050307 ! sucrose-phosphate phosphatase activity created_by: rfoulger creation_date: 2011-09-23T10:34:08Z [Term] id: GO:0036009 name: protein-glutamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine." [GOC:imk, PMID:11847124] xref: Reactome:R-HSA-6800138 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: rfoulger creation_date: 2011-10-03T02:27:05Z [Term] id: GO:0036010 name: protein localization to endosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an endosome." [GOC:yaf] synonym: "protein localisation in endosome" EXACT [GOC:bf] synonym: "protein localization in endosome" EXACT [] is_a: GO:0033365 ! protein localization to organelle created_by: rfoulger creation_date: 2011-10-06T02:42:18Z [Term] id: GO:0036011 name: imaginal disc-derived leg segmentation namespace: biological_process def: "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] is_a: GO:0035285 ! appendage segmentation relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis created_by: rfoulger creation_date: 2011-10-07T04:37:17Z [Term] id: GO:0036012 name: cyanelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma." [GOC:aa, PMID:18976493] synonym: "cyanelle inner envelope membrane" EXACT [PMID:18976493] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0033113 ! cyanelle membrane created_by: rfoulger creation_date: 2011-10-10T01:48:56Z [Term] id: GO:0036013 name: cyanelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope." [GOC:aa] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0033113 ! cyanelle membrane created_by: rfoulger creation_date: 2011-10-10T01:50:56Z [Term] id: GO:0036014 name: cyanelle intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer." [GOC:aa] synonym: "cyanelle envelope lumen" EXACT [GOC:bf] synonym: "cyanelle periplasm" EXACT [PMID:18976493] is_a: GO:0009529 ! plastid intermembrane space relationship: part_of GO:0033112 ! cyanelle envelope created_by: rfoulger creation_date: 2011-10-10T02:12:28Z [Term] id: GO:0036015 name: response to interleukin-3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387] synonym: "response to IL-3" EXACT [GOC:bf] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2011-10-12T10:08:26Z [Term] id: GO:0036016 name: cellular response to interleukin-3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387] synonym: "cellular response to IL-3" EXACT [GOC:bf] is_a: GO:0036015 ! response to interleukin-3 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2011-10-12T10:09:10Z [Term] id: GO:0036017 name: response to erythropoietin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf, PR:000007141] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2011-10-12T10:11:04Z [Term] id: GO:0036018 name: cellular response to erythropoietin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf, PR:000007141] is_a: GO:0036017 ! response to erythropoietin is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2011-10-12T10:12:18Z [Term] id: GO:0036019 name: endolysosome namespace: cellular_component def: "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991] is_a: GO:0005764 ! lysosome is_a: GO:0005768 ! endosome created_by: rfoulger creation_date: 2011-10-13T02:35:13Z [Term] id: GO:0036020 name: endolysosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde] synonym: "endolysosomal membrane" EXACT [GOC:bf] is_a: GO:0005765 ! lysosomal membrane is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0036019 ! endolysosome created_by: rfoulger creation_date: 2011-10-13T04:32:00Z [Term] id: GO:0036021 name: endolysosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde] synonym: "endolysosomal lumen" EXACT [GOC:bf] is_a: GO:0031904 ! endosome lumen is_a: GO:0043202 ! lysosomal lumen relationship: part_of GO:0036019 ! endolysosome created_by: rfoulger creation_date: 2011-10-13T04:32:31Z [Term] id: GO:0036022 name: limb joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf] synonym: "knee morphogenesis" NARROW [GOC:bf] synonym: "leg joint morphogenesis" NARROW [GOC:bf] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0035108 ! limb morphogenesis created_by: rfoulger creation_date: 2011-10-13T04:52:59Z [Term] id: GO:0036023 name: embryonic skeletal limb joint morphogenesis namespace: biological_process def: "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb." [GOC:bf, Wikipedia:Joint] is_a: GO:0036022 ! limb joint morphogenesis is_a: GO:0060272 ! embryonic skeletal joint morphogenesis relationship: part_of GO:0030326 ! embryonic limb morphogenesis created_by: rfoulger creation_date: 2011-10-13T04:57:39Z [Term] id: GO:0036024 name: protein C inhibitor-TMPRSS7 complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7." [GOC:ans, PMID:15853774] synonym: "PCI-TMPRSS7 complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-TMPRSS7 complex" EXACT [PR:000014685] synonym: "protein C inhibitor-matriptase-3 complex" EXACT [PMID:15853774, PR:000016461] synonym: "protein C inhibitor-transmembrane protease serine 7 complex" EXACT [PR:000016461] synonym: "serpin A5-TMPRSS7 complex" EXACT [PR:000014685] synonym: "SERPINA5-TMPRSS7 complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T01:25:06Z [Term] id: GO:0036025 name: protein C inhibitor-TMPRSS11E complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E." [GOC:ans, PMID:15328353] synonym: "PCI-TMPRSS11E complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-TMPRSS11E complex" EXACT [PR:000014685] synonym: "protein C inhibitor-transmembrane protease serine 11E complex" EXACT [PR:000016451] synonym: "serpin A5-TMPRSS11E complex" EXACT [PR:000014685] synonym: "SERPINA5-TMPRSS11E complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T01:29:08Z [Term] id: GO:0036026 name: protein C inhibitor-PLAT complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator." [GOC:ans, PMID:10340997] synonym: "PCI-PLAT complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-PLAT complex" EXACT [PR:000014685] synonym: "protein C inhibitor-tissue-type plasminogen activator complex" EXACT [PMID:10340997, PR:000012825] synonym: "protein C inhibitor-tPA complex" EXACT [PMID:10340997, PR:000012825] synonym: "serpin A5-PLAT complex" EXACT [PR:000014685] synonym: "SERPINA5-PLAT complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T01:30:56Z [Term] id: GO:0036027 name: protein C inhibitor-PLAU complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator." [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714] synonym: "PCI-PLAU complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-PLAU complex" EXACT [PR:000014685] synonym: "protein C inhibitor-U-plasminogen activator complex" EXACT [PR:000012826] synonym: "protein C inhibitor-uPA complex" EXACT [PR:000012826] synonym: "protein C inhibitor-urokinase-type plasminogen activator complex" EXACT [PR:000012826] synonym: "serpin A5-PLAU complex" EXACT [PR:000014685] synonym: "SERPINA5-PLAU complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T01:37:03Z [Term] id: GO:0036028 name: protein C inhibitor-thrombin complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin." [GOC:ans, PMID:6323392] synonym: "PCI-thrombin complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-thrombin complex" EXACT [PR:000014685] synonym: "protein C inhibitor-coagulation factor II complex" EXACT [PR:000007299] synonym: "protein C inhibitor-F2 complex" EXACT [PR:000007299] synonym: "serpin A5-thrombin complex" EXACT [PR:000014685] synonym: "SERPINA5-thrombin complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T01:40:18Z [Term] id: GO:0036029 name: protein C inhibitor-KLK3 complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen." [GOC:ans, PMID:1725227] synonym: "PCI-KLK3 complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-KLK3 complex" EXACT [PR:000014685] synonym: "protein C inhibitor-kallikrein-3 complex" EXACT [PR:000003015] synonym: "protein C inhibitor-prostate-specific antigen complex" EXACT [PR:000003015] synonym: "serpin A5-KLK3 complex" EXACT [PR:000014685] synonym: "SERPINA5-KLK3 complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T02:01:33Z [Term] id: GO:0036030 name: protein C inhibitor-plasma kallikrein complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein." [GOC:ans, PMID:2844223, PMID:8536714] synonym: "PCI-plasma kallikrein complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-plasma kallikrein complex" EXACT [PR:000014685] synonym: "protein C inhibitor-KLKB1 complex" EXACT [PR:000009420] synonym: "serpin A5-plasma kallikrein complex" EXACT [PR:000014685] synonym: "SERPINA5-plasma kallikrein complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: rfoulger creation_date: 2011-10-19T02:05:46Z [Term] id: GO:0036031 name: recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex namespace: biological_process def: "The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript." [GOC:bf, GOC:rb, PMID:10594013] synonym: "capping enzyme targeting to RNA polymerase II" EXACT [PMID:10594013] synonym: "recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex" EXACT [GOC:bf] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping created_by: rfoulger creation_date: 2011-10-24T10:56:46Z [Term] id: GO:0036032 name: neural crest cell delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube." [CL:0000333, PMID:17076275] synonym: "neural crest cell emigration" EXACT [PMID:17076275] synonym: "neural crest cell individualization" EXACT [PMID:17076275] synonym: "neural crest cell segregation" RELATED [PMID:17076275] is_a: GO:0060232 ! delamination created_by: rfoulger creation_date: 2011-10-31T03:50:30Z [Term] id: GO:0036033 name: mediator complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:18391015] is_a: GO:0044877 ! protein-containing complex binding created_by: rfoulger creation_date: 2011-10-31T05:09:12Z [Term] id: GO:0036034 name: mediator complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:17641689] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: rfoulger creation_date: 2011-10-31T05:18:11Z [Term] id: GO:0036035 name: osteoclast development namespace: biological_process def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf] synonym: "osteoclast cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development is_a: GO:0098751 ! bone cell development relationship: part_of GO:0030316 ! osteoclast differentiation created_by: rfoulger creation_date: 2011-11-02T05:20:35Z [Term] id: GO:0036036 name: cardiac neural crest cell delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube." [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374] is_a: GO:0036032 ! neural crest cell delamination created_by: rfoulger creation_date: 2011-11-02T05:23:29Z [Term] id: GO:0036037 name: CD8-positive, alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf] is_a: GO:0046631 ! alpha-beta T cell activation created_by: rfoulger creation_date: 2011-11-03T10:34:12Z [Term] id: GO:0036038 name: MKS complex namespace: cellular_component def: "A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane." [GOC:cilia, GOC:sp, PMID:21422230, PMID:21565611, PMID:21725307, PMID:22179047, PMID:25869670, PMID:26595381, PMID:26982032] comment: Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme. synonym: "B9 complex" NARROW [] synonym: "MKS module" EXACT [] synonym: "TCTN-B9D complex" BROAD [] synonym: "tectonic complex" NARROW [] synonym: "tectonic-like complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0035869 ! ciliary transition zone created_by: rfoulger creation_date: 2011-11-22T11:21:28Z [Term] id: GO:0036039 name: curcumin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the polyphenol, curcumin." [PMID:21467222] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process" EXACT [GOC:obol] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism" EXACT [GOC:obol] synonym: "curcumin metabolism" EXACT [GOC:obol] synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol] synonym: "diferuloylmethane metabolism" EXACT [GOC:obol] synonym: "turmeric yellow metabolic process" EXACT [GOC:obol] synonym: "turmeric yellow metabolism" EXACT [GOC:obol] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042180 ! cellular ketone metabolic process created_by: rfoulger creation_date: 2011-11-22T01:58:57Z [Term] id: GO:0036040 name: curcumin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin." [PMID:21467222] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown" EXACT [GOC:obol] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process" EXACT [GOC:obol] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism" EXACT [GOC:obol] synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation" EXACT [GOC:obol] synonym: "curcumin breakdown" EXACT [GOC:obol] synonym: "curcumin catabolism" EXACT [GOC:obol] synonym: "curcumin degradation" EXACT [GOC:obol] synonym: "diferuloylmethane breakdown" EXACT [GOC:obol] synonym: "diferuloylmethane catabolic process" EXACT [GOC:obol] synonym: "diferuloylmethane catabolism" EXACT [GOC:obol] synonym: "diferuloylmethane degradation" EXACT [GOC:obol] synonym: "turmeric yellow breakdown" EXACT [GOC:obol] synonym: "turmeric yellow catabolic process" EXACT [GOC:obol] synonym: "turmeric yellow catabolism" EXACT [GOC:obol] synonym: "turmeric yellow degradation" EXACT [GOC:obol] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0036039 ! curcumin metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901502 ! ether catabolic process created_by: rfoulger creation_date: 2011-11-22T02:01:05Z [Term] id: GO:0036041 name: long-chain fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:pm, PMID:12641450] synonym: "long chain fatty acid binding" EXACT [PMID:12641450] is_a: GO:0005504 ! fatty acid binding created_by: rfoulger creation_date: 2011-11-24T02:54:39Z [Term] id: GO:0036042 name: long-chain fatty acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:pm] is_a: GO:0000062 ! fatty-acyl-CoA binding created_by: rfoulger creation_date: 2011-11-24T04:31:09Z [Term] id: GO:0036043 name: obsolete microspike namespace: cellular_component def: "OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735] comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044393. synonym: "microspike" EXACT [] is_obsolete: true replaced_by: GO:0044393 created_by: rfoulger creation_date: 2011-12-06T01:31:16Z [Term] id: GO:0036044 name: obsolete protein malonylation namespace: biological_process def: "OBSOLETE. The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp] comment: This term was made obsolete because it accidentally shared the same ID as negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity. New id is GO:0044394. synonym: "protein malonylation" EXACT [] is_obsolete: true replaced_by: GO:0044394 [Term] id: GO:0036045 name: obsolete peptidyl-lysine malonylation namespace: biological_process def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568] comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044392. synonym: "lysine malonylation" EXACT [PMID:21908771] synonym: "peptidyl-lysine malonylation" EXACT [] xref: RESID:AA0568 is_obsolete: true replaced_by: GO:0044392 created_by: rfoulger creation_date: 2011-12-12T09:31:42Z [Term] id: GO:0036046 name: protein demalonylation namespace: biological_process def: "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide." [GOC:sp, PMID:22076378] is_a: GO:0035601 ! protein deacylation created_by: rfoulger creation_date: 2011-12-12T09:38:26Z [Term] id: GO:0036047 name: peptidyl-lysine demalonylation namespace: biological_process def: "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378] is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0036046 ! protein demalonylation created_by: rfoulger creation_date: 2011-12-12T09:39:17Z [Term] id: GO:0036048 name: protein desuccinylation namespace: biological_process def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:sp, PMID:22076378] is_a: GO:0035601 ! protein deacylation created_by: rfoulger creation_date: 2011-12-12T09:42:35Z [Term] id: GO:0036049 name: peptidyl-lysine desuccinylation namespace: biological_process def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378] is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0036048 ! protein desuccinylation created_by: rfoulger creation_date: 2011-12-12T09:44:54Z [Term] id: GO:0036050 name: peptidyl-lysine succinylation namespace: biological_process def: "The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545] xref: RESID:AA0545 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018335 ! protein succinylation created_by: rfoulger creation_date: 2011-12-12T09:51:27Z [Term] id: GO:0036051 name: protein localization to trailing edge namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement." [GOC:pf, GOC:pg] synonym: "protein localisation to trailing edge" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization created_by: rfoulger creation_date: 2011-12-12T10:44:04Z [Term] id: GO:0036052 name: protein localization to uropod namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell." [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "protein localisation to uropod" EXACT [GOC:mah] is_a: GO:0036051 ! protein localization to trailing edge created_by: rfoulger creation_date: 2011-12-12T10:45:26Z [Term] id: GO:0036053 name: glomerular endothelium fenestra namespace: cellular_component def: "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259] synonym: "GEnC fenestration" EXACT [PMID:19129259] synonym: "glomerular endothelial cell fenestration" EXACT [PMID:19129259] is_a: GO:0046930 ! pore complex created_by: rfoulger creation_date: 2011-12-12T10:53:24Z [Term] id: GO:0036054 name: protein-malonyllysine demalonylase activity namespace: molecular_function def: "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378] synonym: "peptidyl-malonyllysine demalonylase activity" EXACT [] synonym: "protein lysine demalonylation activity" EXACT [PMID:21908771] synonym: "protein malonyl lysine demalonylation activity" EXACT [GOC:bf] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides relationship: part_of GO:0036047 ! peptidyl-lysine demalonylation created_by: rfoulger creation_date: 2011-12-12T01:29:21Z [Term] id: GO:0036055 name: protein-succinyllysine desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:22076378] comment: This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. synonym: "peptidyl-succinyllysine desuccinylase activity" EXACT [] synonym: "succinyl lysine desuccinylase activity" BROAD [GOC:bf] synonym: "succinyllysine desuccinylase activity" BROAD [] xref: RHEA:47668 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides relationship: part_of GO:0036049 ! peptidyl-lysine desuccinylation created_by: rfoulger creation_date: 2011-12-12T01:33:51Z [Term] id: GO:0036056 name: filtration diaphragm namespace: cellular_component def: "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] is_a: GO:0005911 ! cell-cell junction created_by: rfoulger creation_date: 2011-12-12T04:36:05Z [Term] id: GO:0036057 name: slit diaphragm namespace: cellular_component def: "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094] is_a: GO:0036056 ! filtration diaphragm created_by: rfoulger creation_date: 2011-12-12T04:36:42Z [Term] id: GO:0036058 name: filtration diaphragm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929] is_a: GO:0007043 ! cell-cell junction assembly created_by: rfoulger creation_date: 2011-12-12T04:38:40Z [Term] id: GO:0036059 name: nephrocyte diaphragm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] is_a: GO:0034333 ! adherens junction assembly is_a: GO:0036058 ! filtration diaphragm assembly created_by: rfoulger creation_date: 2011-12-12T04:38:40Z [Term] id: GO:0036060 name: slit diaphragm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639] is_a: GO:0036058 ! filtration diaphragm assembly created_by: rfoulger creation_date: 2011-12-12T04:38:40Z [Term] id: GO:0036061 name: muscle cell chemotaxis toward tendon cell namespace: biological_process def: "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells." [GOC:sart, PMID:19793885] synonym: "muscle cell attraction" RELATED [GOC:bf] synonym: "muscle cell chemotaxis towards tendon cell" EXACT [GOC:bf, GOC:sart] is_a: GO:0014812 ! muscle cell migration is_a: GO:0060326 ! cell chemotaxis created_by: rfoulger creation_date: 2011-12-14T11:13:40Z [Term] id: GO:0036062 name: presynaptic periactive zone namespace: cellular_component def: "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406] synonym: "periactive zone" EXACT [PMID:10976048, PMID:18439406] synonym: "pre-synaptic periactive zone" EXACT [] is_a: GO:0097060 ! synaptic membrane relationship: part_of GO:0042734 ! presynaptic membrane created_by: rfoulger creation_date: 2011-12-14T02:25:29Z [Term] id: GO:0036063 name: acroblast namespace: cellular_component def: "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220] comment: See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'. synonym: "spermatid acroblast" EXACT [GOC:bf] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005794 ! Golgi apparatus created_by: rfoulger creation_date: 2011-12-14T02:29:05Z [Term] id: GO:0036064 name: ciliary basal body namespace: cellular_component alt_id: GO:0005932 def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "basal body" BROAD [] synonym: "cilial basal body" EXACT [] synonym: "cilium basal body" EXACT [GOC:bf] synonym: "microtubule basal body" EXACT [] xref: NIF_Subcellular:sao11978067 is_a: GO:0005815 ! microtubule organizing center intersection_of: GO:0005815 ! microtubule organizing center intersection_of: part_of GO:0005929 ! cilium relationship: part_of GO:0005929 ! cilium created_by: rfoulger creation_date: 2011-12-15T10:40:20Z [Term] id: GO:0036065 name: fucosylation namespace: biological_process def: "The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734] is_a: GO:0070085 ! glycosylation created_by: rfoulger creation_date: 2011-12-15T11:16:19Z [Term] id: GO:0036066 name: protein O-linked fucosylation namespace: biological_process def: "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734] is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0036065 ! fucosylation created_by: rfoulger creation_date: 2011-12-15T11:17:20Z [Term] id: GO:0036067 name: light-dependent chlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light." [GOC:yaf, PMID:12242396] synonym: "light dependent chlorophyll biosynthetic process" EXACT [GOC:yaf] synonym: "light-dependent chlorophyll anabolism" EXACT [GOC:bf] synonym: "light-dependent chlorophyll biosynthesis" EXACT [GOC:bf] synonym: "light-dependent chlorophyll formation" EXACT [GOC:bf] synonym: "light-dependent chlorophyll synthesis" EXACT [GOC:bf] is_a: GO:0015995 ! chlorophyll biosynthetic process created_by: rfoulger creation_date: 2011-12-15T04:42:47Z [Term] id: GO:0036068 name: light-independent chlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light." [GOC:yaf, PMID:12242396, UniPathway:UPA00670] synonym: "light independent chlorophyll biosynthetic process" EXACT [GOC:yaf] synonym: "light-independent chlorophyll anabolism" EXACT [GOC:bf] synonym: "light-independent chlorophyll biosynthesis" EXACT [GOC:bf] synonym: "light-independent chlorophyll formation" EXACT [GOC:bf] synonym: "light-independent chlorophyll synthesis" EXACT [GOC:bf] is_a: GO:0015995 ! chlorophyll biosynthetic process created_by: rfoulger creation_date: 2011-12-15T04:44:18Z [Term] id: GO:0036069 name: light-dependent bacteriochlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396] synonym: "light dependent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf] synonym: "light-dependent bacteriochlorophyll anabolism" EXACT [GOC:bf] synonym: "light-dependent bacteriochlorophyll biosynthesis" EXACT [GOC:bf] synonym: "light-dependent bacteriochlorophyll formation" EXACT [GOC:bf] synonym: "light-dependent bacteriochlorophyll synthesis" EXACT [GOC:bf] is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process is_a: GO:0036067 ! light-dependent chlorophyll biosynthetic process created_by: rfoulger creation_date: 2011-12-15T04:45:16Z [Term] id: GO:0036070 name: light-independent bacteriochlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396, UniPathway:UPA00671] synonym: "light independent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf] synonym: "light-independent bacteriochlorophyll anabolism" EXACT [GOC:bf] synonym: "light-independent bacteriochlorophyll biosynthesis" EXACT [GOC:bf] synonym: "light-independent bacteriochlorophyll formation" EXACT [GOC:bf] synonym: "light-independent bacteriochlorophyll synthesis" EXACT [GOC:bf] is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process is_a: GO:0036068 ! light-independent chlorophyll biosynthetic process created_by: rfoulger creation_date: 2011-12-15T04:46:25Z [Term] id: GO:0036071 name: N-glycan fucosylation namespace: biological_process def: "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [GOC:sart, PMID:19948734] synonym: "glycoprotein fucosylation" RELATED [GOC:bf] is_a: GO:0036065 ! fucosylation created_by: rfoulger creation_date: 2011-12-15T04:54:24Z [Term] id: GO:0036072 name: direct ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034] is_a: GO:0001503 ! ossification created_by: rfoulger creation_date: 2011-12-19T01:47:22Z [Term] id: GO:0036073 name: perichondral ossification namespace: biological_process def: "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [GO_REF:0000034] is_a: GO:0001957 ! intramembranous ossification created_by: rfoulger creation_date: 2011-12-19T01:49:38Z [Term] id: GO:0036074 name: metaplastic ossification namespace: biological_process def: "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division." [GO_REF:0000034] comment: Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "metaplasia" RELATED [GO_REF:0000034] is_a: GO:0036072 ! direct ossification created_by: rfoulger creation_date: 2011-12-19T01:50:35Z [Term] id: GO:0036075 name: replacement ossification namespace: biological_process def: "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034] synonym: "indirect ossification" EXACT [GO_REF:0000034] is_a: GO:0001503 ! ossification created_by: rfoulger creation_date: 2011-12-19T01:53:16Z [Term] id: GO:0036076 name: ligamentous ossification namespace: biological_process def: "Ossification wherein bone tissue forms within ligamentous tissue." [GO_REF:0000034] comment: Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. is_a: GO:0001503 ! ossification created_by: rfoulger creation_date: 2011-12-19T01:57:08Z [Term] id: GO:0036077 name: intratendonous ossification namespace: biological_process def: "Ossification wherein bone tissue forms within tendonous tissue." [GO_REF:0000034] comment: Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. is_a: GO:0001503 ! ossification created_by: rfoulger creation_date: 2011-12-19T01:57:48Z [Term] id: GO:0036078 name: minus-end specific microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528] is_a: GO:0007019 ! microtubule depolymerization created_by: rfoulger creation_date: 2011-12-19T03:20:25Z [Term] id: GO:0036080 name: purine nucleotide-sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734] is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity relationship: part_of GO:0090480 ! purine nucleotide-sugar transmembrane transport created_by: rfoulger creation_date: 2011-12-19T03:29:06Z [Term] id: GO:0036081 name: extracellular ammonia-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] synonym: "ionotropic ammonia receptor activity" RELATED [PMID:19135896] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity created_by: rfoulger creation_date: 2011-12-20T04:47:48Z [Term] id: GO:0036082 name: extracellular phenylacetaldehyde-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] synonym: "ionotropic phenylacetaldehyde receptor activity" RELATED [PMID:19135896] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity created_by: rfoulger creation_date: 2011-12-20T04:49:31Z [Term] id: GO:0036083 name: obsolete positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9927444] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: rfoulger creation_date: 2011-12-20T04:52:36Z [Term] id: GO:0036084 name: GDP-fucose import into endoplasmic reticulum lumen namespace: biological_process def: "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] synonym: "GDP-fucose import into endoplasmic reticulum" EXACT [GOC:bf] synonym: "GDP-fucose transport across endoplasmic reticulum membrane" EXACT [GOC:bf] synonym: "GDP-fucose transport into endoplasmic reticulum lumen" EXACT [GOC:sart] is_a: GO:0015783 ! GDP-fucose transmembrane transport is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport created_by: rfoulger creation_date: 2011-12-21T01:45:11Z [Term] id: GO:0036085 name: GDP-fucose import into Golgi lumen namespace: biological_process def: "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] synonym: "GDP-fucose import into Golgi" EXACT [GOC:bf] synonym: "GDP-fucose transport across Golgi membrane" EXACT [GOC:bf] synonym: "GDP-fucose transport into Golgi lumen" EXACT [GOC:sart] is_a: GO:0015783 ! GDP-fucose transmembrane transport created_by: rfoulger creation_date: 2011-12-21T01:52:10Z [Term] id: GO:0036086 name: positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:cjk] synonym: "positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:bf] is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress created_by: rfoulger creation_date: 2012-01-05T01:45:26Z [Term] id: GO:0036087 name: glutathione synthase complex namespace: cellular_component def: "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer." [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212] synonym: "glutathione synthetase complex" EXACT [PMID:12734194, PMID:14990577, PMID:1958212] is_a: GO:1902494 ! catalytic complex created_by: rfoulger creation_date: 2012-01-05T04:29:20Z [Term] id: GO:0036088 name: D-serine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:imk] synonym: "D-serine breakdown" EXACT [GOC:bf] synonym: "D-serine catabolism" EXACT [GOC:bf] synonym: "D-serine degradation" EXACT [GOC:bf] is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0070178 ! D-serine metabolic process created_by: rfoulger creation_date: 2012-01-06T10:58:51Z [Term] id: GO:0036089 name: cleavage furrow formation namespace: biological_process def: "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590] comment: Consider also annotating to 'establishment of contractile ring localization involved in cell cycle cytokinesis ; GO:0032188'. synonym: "cleavage furrow positioning" NARROW [PMID:14757750] is_a: GO:0032506 ! cytokinetic process is_a: GO:0099024 ! plasma membrane invagination relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: rfoulger creation_date: 2012-01-10T02:41:03Z [Term] id: GO:0036090 name: cleavage furrow ingression namespace: biological_process def: "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468] comment: Consider also annotating to 'contractile ring contraction involved in cell cycle cytokinesis ; GO:0000916'. synonym: "cleavage furrow contraction" EXACT [PMID:3413069] is_a: GO:0032506 ! cytokinetic process is_a: GO:0099024 ! plasma membrane invagination relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: rfoulger creation_date: 2012-01-10T02:46:05Z [Term] id: GO:0036091 name: positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:rn, PMID:14978214, PMID:18439143] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus created_by: rfoulger creation_date: 2012-01-10T02:54:43Z [Term] id: GO:0036092 name: phosphatidylinositol-3-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [GOC:al, GOC:vw] synonym: "phosphatidylinositol-3-phosphate anabolism" EXACT [GOC:bf] synonym: "phosphatidylinositol-3-phosphate biosynthesis" EXACT [GOC:bf] synonym: "phosphatidylinositol-3-phosphate formation" EXACT [GOC:bf] synonym: "phosphatidylinositol-3-phosphate synthesis" EXACT [GOC:bf] synonym: "PI(3)P biosynthesis" EXACT [] synonym: "PtdIns3P biosynthesis" EXACT [] is_a: GO:0006661 ! phosphatidylinositol biosynthetic process created_by: rfoulger creation_date: 2012-01-13T02:13:57Z [Term] id: GO:0036093 name: germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] is_a: GO:0008283 ! cell population proliferation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007276 ! gamete generation created_by: rfoulger creation_date: 2012-01-17T04:06:27Z [Term] id: GO:0036094 name: small molecule binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_agr subset: goslim_flybase_ribbon is_a: GO:0005488 ! binding created_by: rfoulger creation_date: 2012-01-17T04:20:34Z [Term] id: GO:0036095 name: obsolete positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:jh, PMID:14668363] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "transcriptional activation of genes involved in invasive growth" RELATED [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-24T10:53:28Z [Term] id: GO:0036096 name: obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing namespace: molecular_function def: "OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292] comment: This term was made obsolete because it is not real a process, and was created accidentally. synonym: "3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing" EXACT [] synonym: "exonucleolytic trimming to generate 3' end of miRNA from pre-miRNA" RELATED [GOC:sart] is_obsolete: true created_by: rfoulger creation_date: 2012-01-24T02:29:03Z [Term] id: GO:0036097 name: obsolete pre-miRNA 3'-end processing namespace: biological_process def: "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292] comment: This term was made obsolete because it is not real a process, and was created accidentally. synonym: "microRNA 3'-end processing" BROAD [PMID:22055292] synonym: "miRNA 3'-end processing" BROAD [PMID:22055292] synonym: "pre-miRNA 3'-end processing" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2012-01-24T02:31:37Z [Term] id: GO:0036098 name: male germ-line stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937] is_a: GO:0030718 ! germ-line stem cell population maintenance created_by: rfoulger creation_date: 2012-01-26T01:58:10Z [Term] id: GO:0036099 name: female germ-line stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] is_a: GO:0030718 ! germ-line stem cell population maintenance created_by: rfoulger creation_date: 2012-01-26T01:58:10Z [Term] id: GO:0036100 name: leukotriene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:yaf] synonym: "leukotriene breakdown" EXACT [GOC:bf] synonym: "leukotriene catabolism" EXACT [GOC:bf] synonym: "leukotriene degradation" EXACT [GOC:bf] is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:1901523 ! icosanoid catabolic process created_by: rfoulger creation_date: 2012-01-27T01:26:24Z [Term] id: GO:0036101 name: leukotriene B4 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:yaf, PMID:9799565, UniPathway:UPA00883] synonym: "leukotriene B4 breakdown" EXACT [GOC:bf] synonym: "leukotriene B4 catabolism" EXACT [GOC:bf] synonym: "leukotriene B4 degradation" EXACT [GOC:bf] synonym: "LTB4 catabolism" EXACT [] is_a: GO:0036100 ! leukotriene catabolic process is_a: GO:0036102 ! leukotriene B4 metabolic process is_a: GO:0042758 ! long-chain fatty acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process created_by: rfoulger creation_date: 2012-01-27T01:26:24Z [Term] id: GO:0036102 name: leukotriene B4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:bf] synonym: "LTB4 metabolism" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: rfoulger creation_date: 2012-01-27T01:39:43Z [Term] id: GO:0036103 name: Kdo2-lipid A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:bf] synonym: "Kdo2-lipid A metabolism" EXACT [GOC:bf] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:1901269 ! lipooligosaccharide metabolic process created_by: rfoulger creation_date: 2012-01-27T01:49:16Z [Term] id: GO:0036104 name: Kdo2-lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:yaf, UniPathway:UPA00360] synonym: "di[3-deoxy-D-manno-octulosonyl]-lipid A biosynthesis" EXACT [UniPathway:UPA00360] synonym: "KDO(2)-lipid A biosynthesis" EXACT [UniPathway:UPA00360] synonym: "Kdo2-lipid A anabolism" EXACT [GOC:bf] synonym: "Kdo2-lipid A biosynthesis" EXACT [GOC:bf] synonym: "Kdo2-lipid A formation" EXACT [GOC:bf] synonym: "Kdo2-lipid A synthesis" EXACT [GOC:bf] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0036103 ! Kdo2-lipid A metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:1901271 ! lipooligosaccharide biosynthetic process created_by: rfoulger creation_date: 2012-01-27T01:49:23Z [Term] id: GO:0036105 name: peroxisome membrane class-1 targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner." [GOC:pm, PMID:14709540, PMID:17020786] comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. synonym: "class 1 mPTS binding" EXACT [PMID:14709540] synonym: "PEX19-dependent mPTS binding" RELATED [PMID:14709540] is_a: GO:0033328 ! peroxisome membrane targeting sequence binding created_by: rfoulger creation_date: 2012-01-27T02:02:22Z [Term] id: GO:0036106 name: peroxisome membrane class-2 targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner." [GOC:pm, PMID:14709540, PMID:17020786] comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. synonym: "class 2 mPTS binding" EXACT [PMID:14709540] synonym: "PEX19-independent mPTS binding" RELATED [PMID:14709540] is_a: GO:0033328 ! peroxisome membrane targeting sequence binding created_by: rfoulger creation_date: 2012-01-27T02:02:22Z [Term] id: GO:0036107 name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [PMID:15695810] synonym: "4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process" EXACT [] synonym: "undecaprenyl phosphate alpha-L-Ara4N metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process created_by: rfoulger creation_date: 2012-02-06T02:55:42Z [Term] id: GO:0036108 name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [GOC:yaf, PMID:15695810, UniPathway:UPA00036] synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism" EXACT [GOC:bf] synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis" EXACT [GOC:bf] synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation" EXACT [GOC:bf] synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis" EXACT [GOC:bf] synonym: "undecaprenyl phosphate alpha-L-Ara4N biosynthesis" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0036107 ! 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process created_by: rfoulger creation_date: 2012-02-06T02:58:03Z [Term] id: GO:0036109 name: alpha-linolenic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [PMID:15538555] synonym: "ALA metabolism" EXACT [CHEBI:27432] synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf] xref: Wikipedia:Linoleic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process created_by: rfoulger creation_date: 2012-02-15T10:16:42Z [Term] id: GO:0036110 name: cellular response to inositol starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol." [GOC:al, PMID:19606215] is_a: GO:0009267 ! cellular response to starvation created_by: rfoulger creation_date: 2012-02-15T10:46:07Z [Term] id: GO:0036111 name: very long-chain fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] synonym: "very long-chain fatty acyl CoA metabolic process" EXACT [GOC:bf] synonym: "very long-chain fatty acyl-CoA metabolism" EXACT [GOC:bf] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: rfoulger creation_date: 2012-02-15T11:09:22Z [Term] id: GO:0036112 name: medium-chain fatty-acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:pm] synonym: "medium-chain fatty acyl CoA metabolic process" EXACT [GOC:bf] synonym: "medium-chain fatty acyl-CoA metabolism" EXACT [GOC:bf] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: rfoulger creation_date: 2012-02-15T11:12:19Z [Term] id: GO:0036113 name: very long-chain fatty-acyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] synonym: "very long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] synonym: "very long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] synonym: "very long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] is_a: GO:0036111 ! very long-chain fatty-acyl-CoA metabolic process is_a: GO:0036115 ! fatty-acyl-CoA catabolic process created_by: rfoulger creation_date: 2012-02-15T11:16:11Z [Term] id: GO:0036114 name: medium-chain fatty-acyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:pm] synonym: "medium-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] synonym: "medium-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] synonym: "medium-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] is_a: GO:0036112 ! medium-chain fatty-acyl-CoA metabolic process is_a: GO:0036115 ! fatty-acyl-CoA catabolic process created_by: rfoulger creation_date: 2012-02-15T11:23:16Z [Term] id: GO:0036115 name: fatty-acyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [PMID:10578051] synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf] synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf] synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0035337 ! fatty-acyl-CoA metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901569 ! fatty acid derivative catabolic process created_by: rfoulger creation_date: 2012-02-15T11:26:25Z [Term] id: GO:0036116 name: long-chain fatty-acyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:pm] synonym: "long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] synonym: "long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] synonym: "long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process is_a: GO:0036115 ! fatty-acyl-CoA catabolic process created_by: rfoulger creation_date: 2012-02-15T11:30:24Z [Term] id: GO:0036117 name: hyaluranon cable namespace: cellular_component def: "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089] synonym: "HA cable" EXACT [PMID:16900089] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region created_by: rfoulger creation_date: 2012-02-16T10:53:37Z [Term] id: GO:0036118 name: hyaluranon cable assembly namespace: biological_process def: "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089] synonym: "HA cable assembly" EXACT [PMID:16900089] is_a: GO:0022607 ! cellular component assembly created_by: rfoulger creation_date: 2012-02-16T11:06:58Z [Term] id: GO:0036119 name: response to platelet-derived growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf] synonym: "response to PDGF stimulus" EXACT [GOC:bf] synonym: "response to platelet-derived growth factor stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: rfoulger creation_date: 2012-02-20T02:48:00Z [Term] id: GO:0036120 name: cellular response to platelet-derived growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf] synonym: "cellular response to PDGF stimulus" EXACT [GOC:bf] is_a: GO:0036119 ! response to platelet-derived growth factor is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus created_by: rfoulger creation_date: 2012-02-20T02:49:02Z [Term] id: GO:0036121 name: double-stranded DNA helicase activity namespace: molecular_function alt_id: GO:0033676 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix." [GOC:kmv] synonym: "double-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT [] synonym: "double-stranded DNA-dependent ATPase activity" EXACT [] synonym: "dsDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:kmv] synonym: "dsDNA-dependent ATPase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity created_by: rfoulger creation_date: 2012-02-20T02:53:51Z [Term] id: GO:0036122 name: BMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034] synonym: "bone morphogenetic protein binding" EXACT [GOC:bf] is_a: GO:0019955 ! cytokine binding created_by: rfoulger creation_date: 2012-02-20T02:59:34Z [Term] id: GO:0036123 name: histone H3-K9 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw] synonym: "histone H3 K9 dimethylation" EXACT [] synonym: "histone lysine H3 K9 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0051567 ! histone H3-K9 methylation created_by: rfoulger creation_date: 2012-02-20T03:06:15Z [Term] id: GO:0036124 name: histone H3-K9 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0051567 ! histone H3-K9 methylation created_by: rfoulger creation_date: 2012-02-20T03:08:06Z [Term] id: GO:0036125 name: fatty acid beta-oxidation multienzyme complex namespace: cellular_component def: "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743] comment: For fatty acid beta-oxidation multienzyme complexes located in the mitochondrial matrix, consider instead the term 'mitochondrial fatty acid beta-oxidation multienzyme complex ; GO:0016507'. is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2012-02-28T02:10:39Z [Term] id: GO:0036126 name: sperm flagellum namespace: cellular_component def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is always 'flagellum', hence the primary term name, but the cilium parentage is deliberate. synonym: "sperm cilium" EXACT [] synonym: "sperm tail" EXACT [GOC:sart] is_a: GO:0097729 ! 9+2 motile cilium created_by: rfoulger creation_date: 2012-02-28T02:39:00Z [Term] id: GO:0036127 name: 3-sulfino-L-alanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 3-sulfino-L-alanine (cysteine sulfinate)." [GOC:al, PMID:8346915] synonym: "cysteine sulfinate binding" EXACT [GOC:al] is_a: GO:0016597 ! amino acid binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:1901681 ! sulfur compound binding created_by: rfoulger creation_date: 2012-02-28T03:15:40Z [Term] id: GO:0036128 name: CatSper complex namespace: cellular_component def: "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039] synonym: "CATSPER channel" EXACT [PMID:21224844] synonym: "CatSper channel complex" EXACT [PMID:17478420] is_a: GO:0005891 ! voltage-gated calcium channel complex created_by: rfoulger creation_date: 2012-03-02T10:26:48Z [Term] id: GO:0036129 name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:al] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: rfoulger creation_date: 2012-03-02T10:36:39Z [Term] id: GO:0036130 name: prostaglandin H2 endoperoxidase reductase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)." [GOC:mw, KEGG_REACTION:R02264, PMID:10622721, PMID:14979715, PMID:16475787] synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595] synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932] xref: KEGG_REACTION:R02264 xref: Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0006693 ! prostaglandin metabolic process created_by: rfoulger creation_date: 2012-03-05T09:25:03Z [Term] id: GO:0036131 name: prostaglandin D2 11-ketoreductase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+." [EC:1.1.1.188, GOC:mw, KEGG_REACTION:R02799, PMID:1504718, PMID:3862115] synonym: "PGD2 11-ketoreductase" EXACT [PMID:14996743] synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318] xref: EC:1.1.1.188 xref: KEGG_REACTION:R02799 xref: Reactome:R-HSA-2161614 "PGD2 is reduced to 11-epi-PGF2a by AKRIC3" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0006693 ! prostaglandin metabolic process created_by: rfoulger creation_date: 2012-03-05T10:27:29Z [Term] id: GO:0036132 name: 13-prostaglandin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG_REACTION:R04556, KEGG_REACTION:R04557, PMID:17449869] comment: Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'. synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48] synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] xref: EC:1.3.1.48 xref: KEGG_REACTION:R04556 xref: KEGG_REACTION:R04557 xref: Reactome:R-HSA-2161692 "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0006693 ! prostaglandin metabolic process created_by: rfoulger creation_date: 2012-03-05T10:42:22Z [Term] id: GO:0036133 name: 11-hydroxythromboxane B2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+." [GOC:mw, KEGG_REACTION:R05060, PMID:3461463, PMID:3823488, PMID:8200461] comment: Note that the KEGG_REACTION:R05060 reaction does not stipulate the acceptor group, and is therefore slightly more general than the activity described by GO:0036133. synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314] xref: KEGG_REACTION:R05060 xref: Reactome:R-HSA-2161732 "TXB2 is converted to 11dh-TXB2 by TXDH" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2012-03-05T11:05:09Z [Term] id: GO:0036134 name: 12-hydroxyheptadecatrienoic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515] synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw] xref: Reactome:R-HSA-2161613 "PGH2 is degraded to 12S-HHT and MDA by TBXAS1" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2012-03-05T11:17:34Z [Term] id: GO:0036135 name: Schwann cell migration namespace: biological_process def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function." [CL:0002573, PMID:20335460] is_a: GO:0008347 ! glial cell migration created_by: rfoulger creation_date: 2012-03-06T10:44:39Z [Term] id: GO:0036136 name: kynurenine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate." [EC:2.6.1.-, GOC:pde, PMID:15606768, PMID:4149765] synonym: "L-kynurenine-oxaloacetate transaminase activity" EXACT [GOC:bf] is_a: GO:0036137 ! kynurenine aminotransferase activity created_by: rfoulger creation_date: 2012-03-06T02:14:11Z [Term] id: GO:0036137 name: kynurenine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid." [EC:2.6.1.-, GOC:pde] synonym: "kynurenine-oxo-acid transaminase activity" NARROW [GOC:bf] synonym: "L-kynurenine transaminase activity" EXACT [GOC:bf] is_a: GO:0008483 ! transaminase activity relationship: part_of GO:0097052 ! L-kynurenine metabolic process created_by: rfoulger creation_date: 2012-03-06T02:16:48Z [Term] id: GO:0036138 name: peptidyl-histidine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine." [GOC:reh, PMID:21251231] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018202 ! peptidyl-histidine modification created_by: rfoulger creation_date: 2012-03-07T09:25:25Z [Term] id: GO:0036139 name: peptidyl-histidine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2." [GOC:reh, PMID:21251231] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: rfoulger creation_date: 2012-03-07T09:26:54Z [Term] id: GO:0036140 name: peptidyl-asparagine 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: rfoulger creation_date: 2012-03-07T09:27:44Z [Term] id: GO:0036141 name: L-phenylalanine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate." [GOC:pde, PMID:15606768] synonym: "L-phenylalanine:oxaloacetate transaminase activity" EXACT [GOC:bf] is_a: GO:0070546 ! L-phenylalanine aminotransferase activity created_by: rfoulger creation_date: 2012-03-08T10:35:44Z [Term] id: GO:0036143 name: kringle domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, Wikipedia:Kringle_domain] is_a: GO:0019904 ! protein domain specific binding created_by: rfoulger creation_date: 2012-03-09T09:49:43Z [Term] id: GO:0036145 name: dendritic cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316] synonym: "DC homeostasis" RELATED [PMID:19176316] is_a: GO:0001776 ! leukocyte homeostasis created_by: rfoulger creation_date: 2012-03-12T11:05:36Z [Term] id: GO:0036146 name: cellular response to mycotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:di, PMID:20548963] is_a: GO:0010046 ! response to mycotoxin is_a: GO:0097237 ! cellular response to toxic substance created_by: rfoulger creation_date: 2012-03-12T11:08:22Z [Term] id: GO:0036147 name: rumination namespace: biological_process def: "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again." [GOC:maf, Wikipedia:Rumination] synonym: "digestive rumination" EXACT [Wikipedia:Rumination] is_a: GO:0022600 ! digestive system process created_by: rfoulger creation_date: 2012-03-13T04:35:19Z [Term] id: GO:0036148 name: phosphatidylglycerol acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15485873, PMID:18458083] is_a: GO:0046471 ! phosphatidylglycerol metabolic process created_by: rfoulger creation_date: 2012-03-14T01:14:23Z [Term] id: GO:0036149 name: phosphatidylinositol acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128] is_a: GO:0046488 ! phosphatidylinositol metabolic process created_by: rfoulger creation_date: 2012-03-14T01:27:02Z [Term] id: GO:0036150 name: phosphatidylserine acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083] synonym: "phosphatidyl-L-serine acyl-chain remodeling" NARROW [] is_a: GO:0006658 ! phosphatidylserine metabolic process created_by: rfoulger creation_date: 2012-03-14T01:35:44Z [Term] id: GO:0036151 name: phosphatidylcholine acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18195019, PMID:18458083] is_a: GO:0046470 ! phosphatidylcholine metabolic process created_by: rfoulger creation_date: 2012-03-14T01:54:13Z [Term] id: GO:0036152 name: phosphatidylethanolamine acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083] is_a: GO:0046470 ! phosphatidylcholine metabolic process created_by: rfoulger creation_date: 2012-03-14T02:09:00Z [Term] id: GO:0036153 name: triglyceride acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] synonym: "triacylglycerol acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00422] is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0036155 ! acylglycerol acyl-chain remodeling created_by: rfoulger creation_date: 2012-03-14T02:49:05Z [Term] id: GO:0036154 name: diacylglycerol acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] synonym: "diglyceride acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00165] is_a: GO:0036155 ! acylglycerol acyl-chain remodeling is_a: GO:0046339 ! diacylglycerol metabolic process created_by: rfoulger creation_date: 2012-03-14T02:53:14Z [Term] id: GO:0036155 name: acylglycerol acyl-chain remodeling namespace: biological_process def: "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] synonym: "glyceride acyl-chain remodeling" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process created_by: rfoulger creation_date: 2012-03-14T02:55:00Z [Term] id: GO:0036156 name: inner dynein arm namespace: cellular_component def: "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092] synonym: "inner dynein arm complex" EXACT [] is_a: GO:0005858 ! axonemal dynein complex created_by: rfoulger creation_date: 2012-03-21T01:24:54Z [Term] id: GO:0036157 name: outer dynein arm namespace: cellular_component def: "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174] synonym: "outer dynein arm complex" EXACT [] is_a: GO:0005858 ! axonemal dynein complex created_by: rfoulger creation_date: 2012-03-21T01:25:03Z [Term] id: GO:0036158 name: outer dynein arm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] synonym: "ODA assembly" EXACT [PMID:19944400] is_a: GO:0070286 ! axonemal dynein complex assembly created_by: rfoulger creation_date: 2012-03-21T02:25:01Z [Term] id: GO:0036159 name: inner dynein arm assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] synonym: "IDA assembly" EXACT [PMID:19944400] is_a: GO:0070286 ! axonemal dynein complex assembly created_by: rfoulger creation_date: 2012-03-21T02:25:01Z [Term] id: GO:0036160 name: melanocyte-stimulating hormone secretion namespace: biological_process def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone] synonym: "MSH secretion" EXACT [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion created_by: rfoulger creation_date: 2012-03-26T01:16:55Z [Term] id: GO:0036161 name: calcitonin secretion namespace: biological_process def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm, PR:000027222] is_a: GO:0015893 ! drug transport is_a: GO:0030072 ! peptide hormone secretion created_by: rfoulger creation_date: 2012-03-26T01:30:32Z [Term] id: GO:0036162 name: oxytocin secretion namespace: biological_process def: "The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior." [GOC:cjm, Wikipedia:Oxytocin] is_a: GO:0015893 ! drug transport is_a: GO:0030072 ! peptide hormone secretion created_by: rfoulger creation_date: 2012-03-26T01:43:46Z [Term] id: GO:0036163 name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108] xref: KEGG_REACTION:R06866 is_a: GO:0016831 ! carboxy-lyase activity created_by: rfoulger creation_date: 2012-03-26T01:49:54Z [Term] id: GO:0036164 name: cell-abiotic substrate adhesion namespace: biological_process def: "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules." [GOC:di] synonym: "cell-abiotic surface adhesion" RELATED [GOC:di] is_a: GO:0031589 ! cell-substrate adhesion created_by: rfoulger creation_date: 2012-03-27T11:18:33Z [Term] id: GO:0036165 name: invasive growth in response to heat namespace: biological_process def: "The growth of colonies in filamentous chains of cells as a result of an increase in temperature." [GOC:di, PMID:22365851] synonym: "invasive growth in response to elevated temperature" EXACT [PMID:22365851] synonym: "invasive growth in response to high temperature" EXACT [PMID:22365851] synonym: "invasive growth in response to temperature stimulus" BROAD [GOC:di] is_a: GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat is_a: GO:0036267 ! invasive filamentous growth created_by: rfoulger creation_date: 2012-03-27T11:23:03Z [Term] id: GO:0036166 name: phenotypic switching namespace: biological_process def: "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues." [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching] comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'. synonym: "phenotypic dimorphism" RELATED [Wikipedia:Phenotypic_switching] is_a: GO:0009987 ! cellular process created_by: rfoulger creation_date: 2012-03-27T01:31:28Z [Term] id: GO:0036167 name: phenotypic switching in response to host namespace: biological_process def: "A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching] is_a: GO:0036166 ! phenotypic switching is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0075136 ! response to host created_by: rfoulger creation_date: 2012-03-27T01:44:24Z [Term] id: GO:0036168 name: filamentous growth of a population of unicellular organisms in response to heat namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature." [GOC:di, PMID:17554048] is_a: GO:0009408 ! response to heat is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: rfoulger creation_date: 2012-03-27T03:53:28Z [Term] id: GO:0036169 name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2." [GOC:mw, PMID:620805, PMID:7028108] xref: Reactome:R-HSA-2162195 "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase" is_a: GO:0016831 ! carboxy-lyase activity created_by: rfoulger creation_date: 2012-03-27T04:47:47Z [Term] id: GO:0036170 name: filamentous growth of a population of unicellular organisms in response to starvation namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment." [GOC:di, PMID:17554048] is_a: GO:0042594 ! response to starvation is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: rfoulger creation_date: 2012-03-27T03:53:28Z [Term] id: GO:0036171 name: filamentous growth of a population of unicellular organisms in response to chemical stimulus namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus." [GOC:di, PMID:17554048] is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms relationship: part_of GO:0042221 ! response to chemical created_by: rfoulger creation_date: 2012-03-27T03:53:28Z [Term] id: GO:0036172 name: thiamine salvage namespace: biological_process def: "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis." [PMID:15150256, PMID:16952958] xref: MetaCyc:PWY-6896 xref: MetaCyc:PWY-6897 xref: MetaCyc:PWY-6898 is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0009228 ! thiamine biosynthetic process created_by: rfoulger creation_date: 2012-03-29T10:31:05Z [Term] id: GO:0036173 name: thiosulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with the inorganic anion thiosulfate, a sulfur oxide that has formula O3S2." [GOC:db, PMID:2188959] is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding created_by: rfoulger creation_date: 2012-03-29T10:38:15Z [Term] id: GO:0036174 name: butane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O." [GOC:dh, PMID:17526838, PMID:19383682] synonym: "sBMO" RELATED [PMID:19383682] synonym: "soluble butane monooxygenase" RELATED [PMID:19383682] is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-03-29T10:42:07Z [Term] id: GO:0036175 name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." [EC:1.17.4.1, GOC:bf, GOC:pde, PMID:7476363] xref: Reactome:R-HSA-111742 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)" xref: Reactome:R-HSA-8866405 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)" is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity created_by: rfoulger creation_date: 2012-03-29T11:12:42Z [Term] id: GO:0036176 name: response to neutral pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http:http\://en.wikipedia.org/wiki/PH] is_a: GO:0009268 ! response to pH created_by: rfoulger creation_date: 2012-03-29T01:38:00Z [Term] id: GO:0036177 name: filamentous growth of a population of unicellular organisms in response to pH namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH] is_a: GO:0009268 ! response to pH is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: rfoulger creation_date: 2012-03-29T01:43:04Z [Term] id: GO:0036178 name: filamentous growth of a population of unicellular organisms in response to neutral pH namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus." [GOC:di, PMID:6374461] is_a: GO:0036176 ! response to neutral pH is_a: GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH created_by: rfoulger creation_date: 2012-03-29T01:43:47Z [Term] id: GO:0036179 name: osteoclast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg] synonym: "chondroclast maturation" RELATED [CL:0000092] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0036035 ! osteoclast development created_by: rfoulger creation_date: 2012-03-29T02:04:00Z [Term] id: GO:0036180 name: filamentous growth of a population of unicellular organisms in response to biotic stimulus namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus." [GOC:di] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: rfoulger creation_date: 2012-03-30T04:12:40Z [Term] id: GO:0036181 name: protein localization to linear element namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689] synonym: "protein localisation to linear element" EXACT [GOC:mah] is_a: GO:1903084 ! protein localization to condensed nuclear chromosome created_by: rfoulger creation_date: 2012-03-30T04:14:17Z [Term] id: GO:0036182 name: asperthecin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] synonym: "asperthecin metabolism" EXACT [GOC:bf] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: rfoulger creation_date: 2012-04-16T11:35:24Z [Term] id: GO:0036183 name: asperthecin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] synonym: "asperthecin breakdown" EXACT [GOC:bf] synonym: "asperthecin catabolism" EXACT [GOC:bf] synonym: "asperthecin degradation" EXACT [GOC:bf] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0036182 ! asperthecin metabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1901662 ! quinone catabolic process created_by: rfoulger creation_date: 2012-04-16T11:36:38Z [Term] id: GO:0036184 name: asperthecin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] synonym: "asperthecin biosynthesis" EXACT [GOC:bf] synonym: "asperthecin formation" EXACT [GOC:bf] synonym: "asperthecin synthesis" EXACT [GOC:bf] is_a: GO:0036182 ! asperthecin metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process created_by: rfoulger creation_date: 2012-04-16T11:36:56Z [Term] id: GO:0036185 name: 13-lipoxin reductase activity namespace: molecular_function def: "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." [GOC:mw, PMID:10837478] xref: Reactome:R-HSA-2161844 "15k-LXA4 is reduced to dhk-LXA4 by PTGR1" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2012-04-16T02:28:19Z [Term] id: GO:0036186 name: early phagosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an early phagosome." [GOC:phg] synonym: "early phagocytic vesicle membrane" EXACT [GOC:bf] is_a: GO:0030670 ! phagocytic vesicle membrane relationship: part_of GO:0032009 ! early phagosome created_by: rfoulger creation_date: 2012-04-16T02:37:30Z [Term] id: GO:0036187 name: cell growth mode switching, budding to filamentous namespace: biological_process def: "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di] synonym: "yeast to hyphal transition" RELATED [GOC:di] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells created_by: rfoulger creation_date: 2012-04-18T11:32:57Z [Term] id: GO:0036188 name: abieta-7,13-dien-18-al dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+." [EC:1.2.1.74] synonym: "abietadienal dehydrogenase" BROAD [EC:1.2.1.74] xref: EC:1.2.1.74 xref: KEGG_REACTION:R06357 xref: MetaCyc:1.2.1.74-RXN xref: RHEA:26225 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2012-04-18T01:46:19Z [Term] id: GO:0036189 name: abieta-7,13-diene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O." [EC:1.14.14.144] synonym: "abietadiene hydroxylase" BROAD [EC:1.14.14.144] xref: EC:1.14.14.144 xref: KEGG_REACTION:R06351 xref: MetaCyc:RXN-8507 xref: RHEA:26217 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-19T10:57:05Z [Term] id: GO:0036190 name: indole-2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.137] xref: EC:1.14.14.153 xref: KEGG_REACTION:R07403 xref: RHEA:31899 xref: RHEA:31903 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-19T11:24:48Z [Term] id: GO:0036191 name: indolin-2-one monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O." [EC:1.14.14.157] synonym: "indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.14.157] xref: EC:1.14.14.157 xref: KEGG_REACTION:R07421 xref: RHEA:31919 xref: RHEA:31923 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-19T11:38:01Z [Term] id: GO:0036192 name: 3-hydroxyindolin-2-one monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.139] synonym: "3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)" EXACT [EC:1.14.14.109] xref: EC:1.14.14.109 xref: KEGG_REACTION:R07422 xref: RHEA:31927 xref: RHEA:31934 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-19T11:45:33Z [Term] id: GO:0036193 name: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.140] xref: EC:1.14.14.110 xref: KEGG_REACTION:R07423 xref: RHEA:31939 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-19T11:54:34Z [Term] id: GO:0036194 name: muscle cell projection namespace: cellular_component def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] synonym: "muscle arm" NARROW [GOC:kmv] synonym: "myocyte projection" EXACT [CL:0000187] synonym: "myopodia" NARROW [GOC:kmv] is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: rfoulger creation_date: 2012-04-20T10:20:47Z [Term] id: GO:0036195 name: muscle cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] is_a: GO:0031253 ! cell projection membrane intersection_of: GO:0031253 ! cell projection membrane intersection_of: part_of GO:0036194 ! muscle cell projection relationship: part_of GO:0036194 ! muscle cell projection created_by: rfoulger creation_date: 2012-04-20T10:21:51Z [Term] id: GO:0036196 name: zymosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf] is_a: GO:0016125 ! sterol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: rfoulger creation_date: 2012-04-20T10:27:06Z [Term] id: GO:0036197 name: zymosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf, MetaCyc:PWY-6074] synonym: "zymosterol anabolism" EXACT [GOC:bf] synonym: "zymosterol biosynthesis" EXACT [GOC:bf] synonym: "zymosterol formation" EXACT [GOC:bf] synonym: "zymosterol synthesis" EXACT [GOC:bf] xref: MetaCyc:PWY-6074 xref: UniPathway:UPA00770 is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0036196 ! zymosterol metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: rfoulger creation_date: 2012-04-20T10:28:46Z [Term] id: GO:0036198 name: dTMP salvage namespace: biological_process def: "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis." [GOC:yaf, UniPathway:UPA00578] synonym: "deoxythymidine monophosphate biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578] synonym: "dTMP biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578] xref: UniPathway:UPA00578 is_a: GO:0006231 ! dTMP biosynthetic process is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage created_by: rfoulger creation_date: 2012-04-20T10:33:28Z [Term] id: GO:0036199 name: cholest-4-en-3-one 26-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate." [EC:1.14.15.29] xref: EC:1.14.15.29 xref: KEGG_REACTION:R09859 xref: RHEA:51564 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-20T02:03:05Z [Term] id: GO:0036200 name: 3-ketosteroid 9-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O." [EC:1.14.15.30] synonym: "3-ketosteroid 9alpha-hydroxylase activity" EXACT [EC:1.14.13.142] synonym: "KshAB activity" EXACT [EC:1.14.13.142] xref: EC:1.14.15.30 xref: KEGG_REACTION:R09860 xref: RHEA:32199 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-20T02:09:47Z [Term] id: GO:0036201 name: ent-isokaurene C2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+." [EC:1.14.14.76] xref: EC:1.14.14.76 xref: KEGG_REACTION:R09861 xref: RHEA:56336 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-20T02:21:33Z [Term] id: GO:0036202 name: ent-cassa-12,15-diene 11-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." [EC:1.14.14.112] synonym: "ent-cassadiene C11alpha-hydroxylase activity" EXACT [EC:1.14.14.112] xref: EC:1.14.14.112 xref: KEGG_REACTION:R09866 xref: RHEA:31967 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-20T02:34:13Z [Term] id: GO:0036203 name: taxoid 14-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O." [EC:1.14.13.146] xref: EC:1.14.13.146 xref: KEGG_REACTION:R09867 xref: RHEA:31971 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-20T02:40:54Z [Term] id: GO:0036204 name: abieta-7,13-dien-18-ol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O." [EC:1.14.14.145] xref: EC:1.14.14.145 xref: KEGG_REACTION:R06354 xref: MetaCyc:RXN-12799 xref: RHEA:26221 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-24T02:37:15Z [Term] id: GO:0036205 name: histone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells." [GOC:krc] comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. synonym: "histone protein catabolic process" EXACT [GOC:bf, GOC:jl] is_a: GO:0044257 ! cellular protein catabolic process created_by: rfoulger creation_date: 2012-04-24T04:48:48Z [Term] id: GO:0036206 name: regulation of histone gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. synonym: "regulation of expression of histone-encoding gene" EXACT [GOC:bf] is_a: GO:0010468 ! regulation of gene expression created_by: rfoulger creation_date: 2012-04-24T05:01:28Z [Term] id: GO:0036207 name: positive regulation of histone gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. synonym: "activation of histone gene expression" NARROW [GOC:bf] synonym: "positive regulation of expression of histone-encoding gene" EXACT [GOC:bf] synonym: "up-regulation of histone gene expression" EXACT [GOC:bf] synonym: "upregulation of histone gene expression" EXACT [GOC:bf] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0036206 ! regulation of histone gene expression created_by: rfoulger creation_date: 2012-04-25T09:27:42Z [Term] id: GO:0036208 name: negative regulation of histone gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. synonym: "down-regulation of histone gene expression" EXACT [GOC:bf] synonym: "downregulation of histone gene expression" EXACT [GOC:bf] synonym: "inhibition of histone gene expression" NARROW [GOC:bf] synonym: "negative regulation of expression of histone-encoding gene" EXACT [GOC:bf] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0036206 ! regulation of histone gene expression created_by: rfoulger creation_date: 2012-04-25T09:29:43Z [Term] id: GO:0036209 name: 9beta-pimara-7,15-diene oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 NADPH + 3 H+ = 9beta-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O. This is a three-step reaction: (a) 9beta-pimara-7,15-diene + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-ol + NADP+ + H2O, (b) 9beta-pimara-7,15-dien-19-ol + O2 + NADPH + H+ = 9neta-pimara-7,15-dien-19-al + NADP+ + 2 H2O, (c) 9beta-pimara-7,15-dien-19-al + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-oate + NADP+ + H2O." [EC:1.14.14.111] xref: EC:1.14.14.111 xref: KEGG_REACTION:R09865 xref: RHEA:31951 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-04-25T11:11:55Z [Term] id: GO:0036210 name: protein modification process in other organism namespace: biological_process def: "The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] synonym: "protein modification in other organism" EXACT [GOC:bf] is_a: GO:0036211 ! protein modification process is_a: GO:0044033 ! multi-organism metabolic process created_by: rfoulger creation_date: 2012-04-26T01:29:29Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification created_by: rfoulger creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036212 name: contractile ring maintenance namespace: biological_process def: "The process in which the contractile ring is maintained, typically in response to an internal or external cue." [GOC:mah, GOC:vw] comment: This term can be used to annotate maintenance of either bacterial or fungal contractile rings. is_a: GO:0032506 ! cytokinetic process is_a: GO:0043954 ! cellular component maintenance relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: rfoulger creation_date: 2012-04-26T02:57:39Z [Term] id: GO:0036213 name: contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter." [GOC:mah, GOC:vw] comment: This term can be used to annotate contraction of either bacterial or fungal contractile rings. is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: rfoulger creation_date: 2012-04-26T02:58:18Z [Term] id: GO:0036214 name: contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah, GOC:vw] comment: This term can be used to annotate localization of either bacterial or fungal contractile rings. is_a: GO:0032506 ! cytokinetic process is_a: GO:0051179 ! localization relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: rfoulger creation_date: 2012-04-26T02:58:50Z [Term] id: GO:0036215 name: response to stem cell factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PR:000009345] synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345] synonym: "response to KIT ligand" EXACT [PR:000009345] synonym: "response to SCF" EXACT [PR:000009345] synonym: "response to stem cell factor stimulus" EXACT [GOC:dos] is_a: GO:0034097 ! response to cytokine created_by: rfoulger creation_date: 2012-04-27T10:26:37Z [Term] id: GO:0036216 name: cellular response to stem cell factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444, PR:000009345] synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345] synonym: "cellular response to KIT ligand" EXACT [PR:000009345] synonym: "cellular response to KITLG" EXACT [PMID:18787413] synonym: "cellular response to SCF" EXACT [PR:000009345] is_a: GO:0036215 ! response to stem cell factor is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: rfoulger creation_date: 2012-04-27T10:30:53Z [Term] id: GO:0036217 name: dGTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate." [GOC:dgf, KEGG_REACTION:R01855, PMID:17090528, PMID:22531138] synonym: "2'-deoxyguanosine 5'-triphosphate diphosphohydrolase" EXACT [KEGG_REACTION:R01855] xref: KEGG_REACTION:R01855 xref: RHEA:28362 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036218 name: dTTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate." [GOC:dgf, PMID:22531138] xref: EC:3.6.1 xref: MetaCyc:RXN0-5107 xref: RHEA:28534 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036219 name: GTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GMP + diphosphate." [GOC:dgf, KEGG_REACTION:R00426, PMID:22531138] synonym: "GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase" EXACT [KEGG_REACTION:R00426] synonym: "GTP diphosphohydrolase activity" EXACT [GOC:bf] xref: KEGG_REACTION:R00426 xref: RHEA:29391 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036220 name: ITP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ITP + H2O = IMP + diphosphate." [GOC:dgf, KEGG_REACTION:R00720, PMID:17899088, PMID:22531138] synonym: "inosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00720] xref: KEGG_REACTION:R00720 xref: MetaCyc:RXN0-6382 xref: Reactome:R-HSA-2509827 "ITPA hydrolyses ITP to IMP" xref: RHEA:29399 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036221 name: UTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + H2O = UMP + diphosphate." [GOC:dgf, KEGG_REACTION:R00662, PMID:17899088] synonym: "uridine triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00662] xref: KEGG_REACTION:R00662 xref: RHEA:29395 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036222 name: XTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: XTP + H2O = xanthosine 5'-phosphate + diphosphate." [GOC:dgf, PMID:22531138] synonym: "XTP pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R02720] xref: EC:3.6.1 xref: KEGG_REACTION:R02720 xref: MetaCyc:RXN0-1603 xref: Reactome:R-HSA-2509831 "ITPA hydrolyses XTP to XMP" xref: RHEA:28610 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: rfoulger creation_date: 2012-05-08T01:47:59Z [Term] id: GO:0036223 name: cellular response to adenine starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [GOC:ai] synonym: "cellular response to adenine deprivation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation created_by: rfoulger creation_date: 2012-05-09T02:26:52Z [Term] id: GO:0036224 name: pairing center namespace: cellular_component def: "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment." [GOC:kmv, PMID:18597662] synonym: "homolog recognition region" EXACT [GOC:kmv] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000794 ! condensed nuclear chromosome created_by: rfoulger creation_date: 2012-05-09T02:28:53Z [Term] id: GO:0036225 name: cellular response to vitamin B1 starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [GOC:al, Wikipedia:Thiamine] synonym: "cellular response to thiamin starvation" EXACT [] synonym: "cellular response to vitamin B1 deprivation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation created_by: rfoulger creation_date: 2012-05-09T02:35:55Z [Term] id: GO:0036226 name: obsolete mitotic cell cycle arrest in response to glucose starvation namespace: biological_process def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G2 cell cycle arrest in response to glucose starvation' has been observed. synonym: "cell cycle arrest in response to glucose starvation" BROAD [] is_obsolete: true created_by: rfoulger creation_date: 2012-05-09T02:43:22Z [Term] id: GO:0036227 name: mitotic G2 cell cycle arrest in response to glucose starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201] is_a: GO:0071850 ! mitotic cell cycle arrest created_by: rfoulger creation_date: 2012-05-09T02:45:49Z [Term] id: GO:0036228 name: protein localization to nuclear inner membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane." [GOC:dgf, PMID:16929305] synonym: "protein targeting to INM" RELATED [PMID:16929305] synonym: "protein targeting to nuclear inner membrane" RELATED [] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0090435 ! protein localization to nuclear envelope created_by: rfoulger creation_date: 2012-05-11T10:42:34Z [Term] id: GO:0036230 name: granulocyte activation namespace: biological_process def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn] is_a: GO:0002274 ! myeloid leukocyte activation created_by: rfoulger creation_date: 2012-05-11T10:57:48Z [Term] id: GO:0036234 name: deglucuronidation namespace: biological_process def: "The removal of glucuronic acid from a conjugated substrate." [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473] is_a: GO:0019585 ! glucuronate metabolic process created_by: rfoulger creation_date: 2012-05-18T04:23:04Z [Term] id: GO:0036235 name: acyl deglucuronidation namespace: biological_process def: "The removal of glucuronic acid from an acyl-glucuronide." [GOC:BHF, GOC:vk, PMID:22294686] is_a: GO:0036234 ! deglucuronidation created_by: rfoulger creation_date: 2012-05-18T04:24:11Z [Term] id: GO:0036236 name: acyl glucuronidation namespace: biological_process def: "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside)." [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686] is_a: GO:0052695 ! cellular glucuronidation created_by: rfoulger creation_date: 2012-05-18T04:26:25Z [Term] id: GO:0036237 name: acyl-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate." [GOC:BHF, GOC:vk, PMID:22294686] synonym: "acyl-glucuronide deglucuronidation activity" NARROW [PMID:22294686] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: rfoulger creation_date: 2012-05-18T04:32:25Z [Term] id: GO:0036238 name: gallate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate." [EC:1.13.11.57, PMID:16030014] xref: EC:1.13.11.57 xref: KEGG_REACTION:R09565 xref: MetaCyc:GALLATE-DIOXYGENASE-RXN xref: RHEA:28927 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen created_by: rfoulger creation_date: 2012-05-22T01:54:09Z [Term] id: GO:0036239 name: taxoid 7beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O." [EC:1.14.13.147] xref: EC:1.14.13.147 xref: KEGG_REACTION:R09868 xref: MetaCyc:RXN-12885 xref: RHEA:31975 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2012-05-22T02:13:21Z [Term] id: GO:0036240 name: septal periplasm namespace: cellular_component def: "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi." [GOC:di, PMID:21564341] synonym: "cell wall-enclosed septal periplasm" EXACT [GOC:di] is_a: GO:0042597 ! periplasmic space created_by: rfoulger creation_date: 2012-05-23T10:18:09Z [Term] id: GO:0036241 name: glutamate catabolic process to 4-hydroxybutyrate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321] comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase. synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321] is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process relationship: has_part GO:0047577 ! 4-hydroxybutyrate dehydrogenase activity created_by: rfoulger creation_date: 2012-05-23T02:17:05Z [Term] id: GO:0036242 name: glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, MetaCyc:PWY-4321] comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. synonym: "glutamate degradation via gamma aminobutyrate transaminase activity" EXACT [MetaCyc:PWY-4321] xref: MetaCyc:PWY-4321 xref: MetaCyc:PWY3O-210 is_a: GO:0006540 ! glutamate decarboxylation to succinate relationship: has_part GO:0034386 ! 4-aminobutyrate:2-oxoglutarate transaminase activity created_by: rfoulger creation_date: 2012-05-23T02:28:33Z [Term] id: GO:0036243 name: succinate-semialdehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [EC:1.2.1.79, GOC:bf] comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.79] synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.79] synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79] synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79] is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity created_by: rfoulger creation_date: 2012-05-23T02:47:52Z [Term] id: GO:0036244 name: cellular response to neutral pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH] is_a: GO:0036176 ! response to neutral pH is_a: GO:0071467 ! cellular response to pH created_by: rfoulger creation_date: 2012-05-28T10:21:03Z [Term] id: GO:0036245 name: cellular response to menadione namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al, Wikipedia:Menadione] synonym: "cellular response to vitamin K3" EXACT [GOC:al] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901655 ! cellular response to ketone created_by: rfoulger creation_date: 2012-05-28T10:23:02Z [Term] id: GO:0036246 name: phytochelatin 2 import into vacuole namespace: biological_process def: "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] synonym: "PC2 import into vacuole" EXACT [GOC:al] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0071995 ! phytochelatin import into vacuole created_by: rfoulger creation_date: 2012-05-31T11:09:20Z [Term] id: GO:0036247 name: phytochelatin 3 import into vacuole namespace: biological_process def: "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] synonym: "PC3 import into vacuole" EXACT [GOC:al] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0071995 ! phytochelatin import into vacuole created_by: rfoulger creation_date: 2012-05-31T11:11:03Z [Term] id: GO:0036248 name: phytochelatin 4 import into vacuole namespace: biological_process def: "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] synonym: "PC4 import into vacuole" EXACT [GOC:al] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0071995 ! phytochelatin import into vacuole created_by: rfoulger creation_date: 2012-05-31T11:12:08Z [Term] id: GO:0036249 name: cadmium ion import into vacuole namespace: biological_process def: "The directed movement of cadmium ions into the vacuole." [GOC:al] synonym: "vacuolar cadmium import" RELATED [GOC:bf] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: rfoulger creation_date: 2012-05-31T11:13:44Z [Term] id: GO:0036250 name: peroxisome transport along microtubule namespace: biological_process def: "The directed movement of a peroxisome along a microtubule, mediated by motor proteins." [GOC:pm, PMID:21525035] is_a: GO:0072384 ! organelle transport along microtubule created_by: rfoulger creation_date: 2012-05-31T03:09:09Z [Term] id: GO:0036251 name: positive regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al] is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress created_by: rfoulger creation_date: 2012-06-12T11:38:22Z [Term] id: GO:0036252 name: positive regulation of transcription from RNA polymerase II promoter in response to menadione namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al] synonym: "positive regulation of transcription from RNA polymerase II promoter in response to menadione stress" NARROW [GOC:al] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0036245 ! cellular response to menadione created_by: rfoulger creation_date: 2012-06-12T11:40:58Z [Term] id: GO:0036253 name: response to amiloride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0036270 ! response to diuretic created_by: rfoulger creation_date: 2012-06-15T01:05:35Z [Term] id: GO:0036254 name: cellular response to amiloride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0036253 ! response to amiloride is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: rfoulger creation_date: 2012-06-15T01:06:16Z [Term] id: GO:0036255 name: response to methylamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] is_a: GO:0014075 ! response to amine is_a: GO:0060359 ! response to ammonium ion created_by: rfoulger creation_date: 2012-06-15T01:07:27Z [Term] id: GO:0036256 name: cellular response to methylamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] is_a: GO:0036255 ! response to methylamine is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071418 ! cellular response to amine stimulus created_by: rfoulger creation_date: 2012-06-15T01:08:00Z [Term] id: GO:0036257 name: multivesicular body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881] synonym: "MVB organization" EXACT [GOC:bf] is_a: GO:0007032 ! endosome organization created_by: rfoulger creation_date: 2012-06-15T01:09:53Z [Term] id: GO:0036258 name: multivesicular body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114] synonym: "multivesicular body biogenesis" EXACT [PMID:19571114] synonym: "MVB biogenesis" EXACT [PMID:19571114] synonym: "MVB formation" EXACT [PMID:19571114] is_a: GO:0036257 ! multivesicular body organization is_a: GO:0070925 ! organelle assembly created_by: rfoulger creation_date: 2012-06-15T01:12:24Z [Term] id: GO:0036259 name: aerobic raffinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen." [GOC:al, PMID:10082789] synonym: "aerobic raffinose breakdown" EXACT [GOC:bf] synonym: "aerobic raffinose catabolism" EXACT [GOC:bf] synonym: "aerobic raffinose degradation" EXACT [GOC:bf] is_a: GO:0034484 ! raffinose catabolic process created_by: rfoulger creation_date: 2012-06-15T01:14:51Z [Term] id: GO:0036260 name: RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673] is_a: GO:0006396 ! RNA processing created_by: rfoulger creation_date: 2012-06-15T02:10:23Z [Term] id: GO:0036261 name: 7-methylguanosine cap hypermethylation namespace: biological_process def: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984] synonym: "2,2,7-trimethylguanosine cap formation" EXACT [PMID:11983179] synonym: "conversion of m(7)G to m(3)G" EXACT [PMID:11983179] synonym: "hypermethylation of snoRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] synonym: "hypermethylation of snRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] synonym: "m(7)G cap hypermethylation" EXACT [GOC:bf] synonym: "snoRNA capping" NARROW [GOC:rl] synonym: "snRNA capping" NARROW [GOC:rl] synonym: "TMG cap formation" EXACT [PMID:11983179] is_a: GO:0001510 ! RNA methylation is_a: GO:0036260 ! RNA capping created_by: rfoulger creation_date: 2012-06-15T02:21:39Z [Term] id: GO:0036262 name: granulysin production namespace: biological_process def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000008119] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: rfoulger creation_date: 2012-06-18T02:11:15Z [Term] id: GO:0036263 name: L-DOPA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533] is_a: GO:0004097 ! catechol oxidase activity created_by: rfoulger creation_date: 2012-06-21T03:57:13Z [Term] id: GO:0036264 name: dopamine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533] is_a: GO:0004097 ! catechol oxidase activity created_by: rfoulger creation_date: 2012-06-21T04:11:30Z [Term] id: GO:0036265 name: RNA (guanine-N7)-methylation namespace: biological_process def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl] is_a: GO:0001510 ! RNA methylation created_by: rfoulger creation_date: 2012-06-25T10:28:25Z [Term] id: GO:0036266 name: Cdc48p-Npl4p-Vms1p AAA ATPase complex namespace: cellular_component def: "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p." [GOC:rn, PMID:21070972, PMID:21936843] synonym: "Cdc48p-Npl4p-Vms1p complex" EXACT [GOC:rn] synonym: "Vms1-Cdc48-Npl4 complex" EXACT [GOC:rn] synonym: "Vms1p-Cdc48p-Npl4p complex" EXACT [GOC:rn] is_a: GO:0098799 ! outer mitochondrial membrane protein complex created_by: rfoulger creation_date: 2012-06-29T10:57:48Z [Term] id: GO:0036267 name: invasive filamentous growth namespace: biological_process def: "The growth of colonies in filamentous chains of cells into a substrate." [GOC:di, PMID:22276126] synonym: "invasive growth" EXACT [GOC:di] is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells created_by: rfoulger creation_date: 2012-07-02T01:42:24Z [Term] id: GO:0036268 name: swimming namespace: biological_process def: "Self-propelled movement of an organism from one location to another through water, often by means of active fin movement." [GOC:cvs, PMID:22459995] comment: For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'. is_a: GO:0040011 ! locomotion created_by: rfoulger creation_date: 2012-07-04T10:12:24Z [Term] id: GO:0036269 name: swimming behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679] synonym: "swimming behaviour" EXACT [PMID:16764679] is_a: GO:0007626 ! locomotory behavior created_by: rfoulger creation_date: 2012-07-04T10:14:49Z [Term] id: GO:0036270 name: response to diuretic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T01:26:24Z [Term] id: GO:0036271 name: response to methylphenidate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [GOC:hp, Wikipedia:Methylphenidate] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to MPD" EXACT [CHEBI:6887] synonym: "response to MPH" EXACT [CHEBI:6887] synonym: "response to ritalin" EXACT [CHEBI:6887] is_a: GO:0042493 ! response to drug is_a: GO:0060359 ! response to ammonium ion created_by: rfoulger creation_date: 2012-07-09T01:30:57Z [Term] id: GO:0036272 name: response to gemcitabine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [GOC:hp, Wikipedia:Gemcitabine] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901] synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T01:36:03Z [Term] id: GO:0036273 name: response to statin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664] synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664] is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T01:54:01Z [Term] id: GO:0036274 name: response to lapatinib namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-09T02:02:26Z [Term] id: GO:0036275 name: response to 5-fluorouracil namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345] synonym: "response to fluorouracil" EXACT [GOC:hp] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite created_by: rfoulger creation_date: 2012-07-09T02:08:23Z [Term] id: GO:0036276 name: response to antidepressant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T02:12:44Z [Term] id: GO:0036277 name: response to anticonvulsant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042493 ! response to drug created_by: rfoulger creation_date: 2012-07-09T02:40:12Z [Term] id: GO:0036278 name: positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen." [GOC:al, PMID:21118960] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0006995 ! cellular response to nitrogen starvation intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II created_by: rfoulger creation_date: 2012-07-11T11:02:55Z [Term] id: GO:0036279 name: positive regulation of protein export from nucleus in response to glucose starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose." [GOC:al, PMID:3541942] is_a: GO:0042149 ! cellular response to glucose starvation is_a: GO:0046827 ! positive regulation of protein export from nucleus created_by: rfoulger creation_date: 2012-07-11T11:05:20Z [Term] id: GO:0036280 name: cellular response to L-canavanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [GOC:al] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901354 ! response to L-canavanine created_by: rfoulger creation_date: 2012-07-11T11:09:37Z [Term] id: GO:0036281 name: coflocculation namespace: biological_process def: "The non-sexual aggregation between single-celled organisms of different species." [GOC:al, PMID:11472912, PMID:11693916] synonym: "co-flocculation" EXACT [PMID:10689163] is_a: GO:0044419 ! interspecies interaction between organisms is_a: GO:0098630 ! aggregation of unicellular organisms created_by: rfoulger creation_date: 2012-07-11T01:28:39Z [Term] id: GO:0036282 name: coflocculation via protein-carbohydrate interaction namespace: biological_process def: "The non-sexual aggregation between single-celled organisms of different species mediated by interaction of a protein in one species and a carbohydrate in the other species. For example, coflocculation between S. pombe and E. coli is mediated by mannose residues in the yeast cell wall interacting with lectin protein in E. coli cell projections." [GOC:al, PMID:11472912, PMID:11693916] synonym: "coflocculation via lectin-mannose interaction" NARROW [PMID:11693916] is_a: GO:0036281 ! coflocculation created_by: rfoulger creation_date: 2012-07-11T01:30:40Z [Term] id: GO:0036283 name: obsolete positive regulation of transcription factor import into nucleus in response to oxidative stress namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress." [GOC:al, PMID:9585505] comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. synonym: "positive regulation of transcription factor import into nucleus in response to hydrogen peroxide" RELATED [GOC:al] is_obsolete: true created_by: rfoulger creation_date: 2012-07-11T01:46:10Z [Term] id: GO:0036284 name: tubulobulbar complex namespace: cellular_component def: "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523] synonym: "TBC" EXACT [GOC:sl, PMID:22510523] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2012-07-16T10:26:35Z [Term] id: GO:0036285 name: SAGA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315] synonym: "SAGA complex formation" EXACT [GOC:bf] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: rfoulger creation_date: 2012-07-16T10:30:00Z [Term] id: GO:0036286 name: eisosome filament namespace: cellular_component def: "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945] synonym: "linear eisosome" EXACT [GOC:vw] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030863 ! cortical cytoskeleton relationship: part_of GO:0032126 ! eisosome created_by: rfoulger creation_date: 2012-07-16T10:52:24Z [Term] id: GO:0036287 name: response to iloperidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0071867 ! response to monoamine is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: rfoulger creation_date: 2012-07-16T05:01:29Z [Term] id: GO:0036288 name: response to ximelagatran namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-07-16T05:03:56Z [Term] id: GO:0036289 name: peptidyl-serine autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein." [GOC:pm] synonym: "serine autophosphorylation" EXACT [GOC:bf] is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:0046777 ! protein autophosphorylation created_by: rfoulger creation_date: 2012-07-18T10:24:32Z [Term] id: GO:0036290 name: protein trans-autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151] synonym: "trans-autophosphorylation" EXACT [GOC:jsg] is_a: GO:0046777 ! protein autophosphorylation created_by: rfoulger creation_date: 2012-07-18T10:27:06Z [Term] id: GO:0036291 name: protein cis-autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own amino acid residues." [GOC:jsg, PMID:9201908] synonym: "cis-autophosphorylation" EXACT [GOC:jsg] is_a: GO:0046777 ! protein autophosphorylation created_by: rfoulger creation_date: 2012-07-18T10:27:06Z [Term] id: GO:0036292 name: DNA rewinding namespace: biological_process def: "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634] synonym: "DNA annealing" RELATED [GOC:sp] synonym: "RPA-dependent DNA rewinding" NARROW [PMID:21078962] synonym: "single-stranded DNA bubble rewinding" NARROW [PMID:18974355] is_a: GO:0032392 ! DNA geometric change relationship: has_part GO:0000733 ! DNA strand renaturation created_by: rfoulger creation_date: 2012-07-18T10:43:41Z [Term] id: GO:0036293 name: response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. synonym: "response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:05:46Z [Term] id: GO:0036294 name: cellular response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'. synonym: "cellular response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0036293 ! response to decreased oxygen levels is_a: GO:0071453 ! cellular response to oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:08:40Z [Term] id: GO:0036295 name: cellular response to increased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al] comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'cellular response to hyperoxia ; GO:0071455'. synonym: "cellular response to raised oxygen levels" EXACT [GOC:bf] is_a: GO:0036296 ! response to increased oxygen levels is_a: GO:0071453 ! cellular response to oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:09:39Z [Term] id: GO:0036296 name: response to increased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al] comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'response to hyperoxia ; GO:0055093. synonym: "response to raised oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:10:48Z [Term] id: GO:0036297 name: interstrand cross-link repair namespace: biological_process def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477] synonym: "ICL repair" EXACT [PMID:20658649] is_a: GO:0006281 ! DNA repair created_by: rfoulger creation_date: 2012-08-07T11:05:19Z [Term] id: GO:0036298 name: recombinational interstrand cross-link repair namespace: biological_process def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:vw, PMID:20658649] synonym: "recombination-dependent interstrand cross-link repair" EXACT [GOC:vw] is_a: GO:0000725 ! recombinational repair is_a: GO:0036297 ! interstrand cross-link repair created_by: rfoulger creation_date: 2012-08-07T11:11:59Z [Term] id: GO:0036299 name: non-recombinational interstrand cross-link repair namespace: biological_process def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination." [GOC:vw, PMID:11154259, PMID:22064477] synonym: "recombination-independent ICL repair" EXACT [GOC:vw] synonym: "recombination-independent interstrand cross-link repair" EXACT [GOC:vw] is_a: GO:0000726 ! non-recombinational repair is_a: GO:0036297 ! interstrand cross-link repair created_by: rfoulger creation_date: 2012-08-07T11:11:59Z [Term] id: GO:0036300 name: B cell receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell." [GOC:add, GOC:amm] synonym: "B cell receptor uptake of antigen" NARROW [PMID:10996020] synonym: "BCR endocytosis" EXACT [GOC:bf] synonym: "BCR receptor internalization" EXACT [GOC:amm] is_a: GO:0031623 ! receptor internalization created_by: rfoulger creation_date: 2012-08-07T11:24:20Z [Term] id: GO:0036301 name: macrophage colony-stimulating factor production namespace: biological_process def: "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk] synonym: "M-CSF production" EXACT [GOC:vk] is_a: GO:0001816 ! cytokine production created_by: rfoulger creation_date: 2012-08-07T14:07:13Z [Term] id: GO:0036302 name: atrioventricular canal development namespace: biological_process def: "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle." [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: rfoulger creation_date: 2012-08-08T09:55:37Z [Term] id: GO:0036303 name: lymph vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001945 ! lymph vessel development created_by: rfoulger creation_date: 2012-08-08T10:08:47Z [Term] id: GO:0036304 name: umbilical cord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0061027 ! umbilical cord development created_by: rfoulger creation_date: 2012-08-08T10:12:11Z [Term] id: GO:0036305 name: ameloblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation created_by: rfoulger creation_date: 2012-08-08T13:49:15Z [Term] id: GO:0036306 name: embryonic heart tube elongation namespace: biological_process def: "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:BHF, GOC:gr, PMID:15901664] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035050 ! embryonic heart tube development created_by: rfoulger creation_date: 2012-08-08T13:54:37Z [Term] id: GO:0036307 name: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA." [GOC:imk, PMID:22847818] is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity created_by: rfoulger creation_date: 2012-08-08T14:15:48Z [Term] id: GO:0036308 name: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine." [GOC:imk, PMID:22079366] is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity created_by: rfoulger creation_date: 2012-08-08T14:17:44Z [Term] id: GO:0036309 name: protein localization to M-band namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere." [GOC:BHF, GOC:rl, PMID:18782775] synonym: "cellular protein localization to M-band" EXACT [GOC:rl] synonym: "protein localization to M disc" EXACT [GOC:rl] synonym: "protein localization to M line" NARROW [GOC:rl] synonym: "protein localization to mesophragma" EXACT [GOC:rl] is_a: GO:0033365 ! protein localization to organelle created_by: rfoulger creation_date: 2012-08-14T14:02:58Z [Term] id: GO:0036310 name: annealing helicase activity namespace: molecular_function def: "Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA)." [GOC:bf, GOC:sp, PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634] synonym: "annealing activity" BROAD [GOC:bf] synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp] synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf] is_a: GO:0017111 ! nucleoside-triphosphatase activity is_a: GO:0097617 ! annealing activity is_a: GO:0140097 ! catalytic activity, acting on DNA intersection_of: GO:0017111 ! nucleoside-triphosphatase activity intersection_of: part_of GO:0000733 ! DNA strand renaturation relationship: part_of GO:0000733 ! DNA strand renaturation created_by: rfoulger creation_date: 2012-08-14T15:24:29Z [Term] id: GO:0036311 name: chitin disaccharide deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate." [EC:3.5.1.105, GOC:imk] comment: In contrast to EC 3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide. synonym: "chitin oligosaccharide amidohydrolase activity" EXACT [EC:3.5.1.105] synonym: "chitin oligosaccharide deacetylase activity" EXACT [EC:3.5.1.105] synonym: "chitobiose amidohydrolase activity" EXACT [EC:3.5.1.105] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: rfoulger creation_date: 2012-08-15T15:18:09Z [Term] id: GO:0036312 name: phosphatidylinositol 3-kinase regulatory subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location." [GOC:bf, PMID:20505341] synonym: "p85 binding" RELATED [PMID:10627473, PMID:20505341] synonym: "PI3K regulatory subunit binding" EXACT [GOC:bf] is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding created_by: rfoulger creation_date: 2012-08-16T10:58:45Z [Term] id: GO:0036313 name: phosphatidylinositol 3-kinase catalytic subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214] synonym: "p110 binding" RELATED [PMID:17475214] synonym: "PI3K catalytic subunit binding" EXACT [GOC:bf] is_a: GO:0019900 ! kinase binding is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding created_by: rfoulger creation_date: 2012-08-16T10:58:45Z [Term] id: GO:0036314 name: response to sterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound created_by: rfoulger creation_date: 2012-08-21T14:50:14Z [Term] id: GO:0036315 name: cellular response to sterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf] is_a: GO:0036314 ! response to sterol is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: rfoulger creation_date: 2012-08-21T14:51:21Z [Term] id: GO:0036316 name: SREBP-SCAP complex retention in endoplasmic reticulum namespace: biological_process def: "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117] comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937. is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum is_a: GO:2000639 ! negative regulation of SREBP signaling pathway relationship: part_of GO:0036315 ! cellular response to sterol created_by: rfoulger creation_date: 2012-08-21T14:53:08Z [Term] id: GO:0036317 name: tyrosyl-RNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis." [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287] synonym: "unlinkase activity" EXACT [PMID:21408223] synonym: "uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity" EXACT [PMID:21408223] synonym: "VPg unlinkase activity" EXACT [GOC:sp, PMID:21408223, PMID:22908287] synonym: "Y-pUpN PDE activity" EXACT [PMID:21408223] is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: rfoulger creation_date: 2012-08-30T11:08:04Z [Term] id: GO:0036318 name: peptide pheromone receptor activity namespace: molecular_function def: "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:al] is_a: GO:0008528 ! G protein-coupled peptide receptor activity is_a: GO:0016503 ! pheromone receptor activity created_by: rfoulger creation_date: 2012-08-30T16:45:14Z [Term] id: GO:0036319 name: mating-type M-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [GOC:al, PMID:7941744] synonym: "M-factor mating pheromone receptor activity" EXACT [] synonym: "M-factor receptor activity" EXACT [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity created_by: rfoulger creation_date: 2012-08-30T16:51:12Z [Term] id: GO:0036320 name: mating-type P-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086, PMID:886120] synonym: "P-factor mating pheromone receptor activity" EXACT [2] synonym: "P-factor receptor activity" EXACT [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity created_by: rfoulger creation_date: 2012-08-30T16:55:30Z [Term] id: GO:0036321 name: ghrelin secretion namespace: biological_process def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin] synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm] is_a: GO:0015893 ! drug transport is_a: GO:0030072 ! peptide hormone secretion created_by: rfoulger creation_date: 2012-09-04T14:16:43Z [Term] id: GO:0036322 name: pancreatic polypeptide secretion namespace: biological_process def: "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide] synonym: "PP secretion" NARROW [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion created_by: rfoulger creation_date: 2012-09-04T14:39:03Z [Term] id: GO:0036323 name: vascular endothelial growth factor receptor-1 signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007563, Wikipedia:FLT1, Wikipedia:VEGF_receptors] synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563] synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Reactome:R-HSA-194311, Wikipedia:VEGF_receptors] synonym: "VEGFR1 signaling pathway" EXACT [Reactome:R-HSA-194311] is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway created_by: rfoulger creation_date: 2012-09-04T15:11:21Z [Term] id: GO:0036324 name: vascular endothelial growth factor receptor-2 signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] synonym: "FLK-1 signaling pathway" EXACT [PR:000002112] synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor] synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Reactome:R-HSA-194310, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] synonym: "VEGFR2 signaling pathway" EXACT [Reactome:R-HSA-194310] is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway created_by: rfoulger creation_date: 2012-09-04T15:15:40Z [Term] id: GO:0036325 name: vascular endothelial growth factor receptor-3 signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007565, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3] synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565] synonym: "VEGFR-3 signaling pathway" EXACT [Reactome:R-HSA-194308, Wikipedia:VEGF_receptors] synonym: "VEGFR3 signaling pathway" EXACT [Reactome:R-HSA-194310, Wikipedia:VEGFR3] is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway created_by: rfoulger creation_date: 2012-09-04T15:25:13Z [Term] id: GO:0036326 name: VEGF-A-activated receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017284, Wikipedia:VEGF-A] synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf, PR:000017284] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2012-09-04T15:33:19Z [Term] id: GO:0036327 name: VEGF-B-activated receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000003096, Wikipedia:VEGF-B] synonym: "vascular endothelial growth factor B-activated receptor activity" EXACT [GOC:bf, PR:000003096] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2012-09-04T15:36:05Z [Term] id: GO:0036328 name: VEGF-C-activated receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017285, Wikipedia:VEGF-C] synonym: "vascular endothelial growth factor C-activated receptor activity" EXACT [GOC:bf, PR:000017285] synonym: "VEGFC-activated receptor activity" EXACT [PR:000017285] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2012-09-04T15:37:17Z [Term] id: GO:0036329 name: VEGF-D-activated receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000007520, Wikipedia:VEGF-D] synonym: "C-fos induced growth factor receptor activity" EXACT [PR:000007520, Wikipedia:VEGF-D] synonym: "vascular endothelial growth factor D-activated receptor activity" EXACT [GOC:bf, PR:000007520] synonym: "VEGFD-activated receptor activity" EXACT [PR:000017285] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2012-09-04T15:38:31Z [Term] id: GO:0036330 name: VEGF-E-activated receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor E (VEGF-E) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19909239] synonym: "vascular endothelial growth factor E-activated receptor activity" EXACT [PMID:19909239] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity relationship: part_of GO:0036324 ! vascular endothelial growth factor receptor-2 signaling pathway created_by: rfoulger creation_date: 2012-09-04T15:41:31Z [Term] id: GO:0036331 name: avascular cornea development in camera-type eye namespace: biological_process def: "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees." [GOC:uh, PMID:16849433, PMID:17051153] synonym: "avascular cornea development" EXACT [GOC:bf] is_a: GO:0061303 ! cornea development in camera-type eye created_by: rfoulger creation_date: 2012-09-05T09:07:14Z [Term] id: GO:0036332 name: placental growth factor-activated receptor activity namespace: molecular_function def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, PR:000012605, Wikipedia:Placental_growth_factor] synonym: "placental growth factor receptor activity" EXACT [GOC:bf] synonym: "PlGF receptor activity" RELATED [PMID:12871269] synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0036323 ! vascular endothelial growth factor receptor-1 signaling pathway created_by: rfoulger creation_date: 2012-09-05T09:34:37Z [Term] id: GO:0036333 name: hepatocyte homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874] is_a: GO:0048872 ! homeostasis of number of cells created_by: rfoulger creation_date: 2012-09-05T10:17:07Z [Term] id: GO:0036334 name: epidermal stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529] is_a: GO:0048872 ! homeostasis of number of cells created_by: rfoulger creation_date: 2012-09-05T10:21:23Z [Term] id: GO:0036335 name: intestinal stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] is_a: GO:0048872 ! homeostasis of number of cells created_by: rfoulger creation_date: 2012-09-05T10:23:41Z [Term] id: GO:0036336 name: dendritic cell migration namespace: biological_process def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990] is_a: GO:0050900 ! leukocyte migration created_by: rfoulger creation_date: 2012-09-05T10:24:46Z [Term] id: GO:0036337 name: Fas signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily." [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor] synonym: "Apo-1 signaling pathway" EXACT [PMID:12040174] synonym: "CD95 signaling pathway" EXACT [PMID:12040174] synonym: "FAS ligand-Fas signaling pathway" NARROW [PMID:12040174] synonym: "Fas receptor signaling pathway" EXACT [Wikipedia:Fas_receptor] synonym: "Fas-FasL signaling pathway" NARROW [GOC:bf] synonym: "FasL signaling pathway" RELATED [Wikipedia:Fas_ligand] synonym: "FasR signaling pathway" EXACT [Wikipedia:Fas_receptor] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2012-09-05T10:28:11Z [Term] id: GO:0036338 name: viral membrane namespace: cellular_component def: "The lipid bilayer of a virion, a complete fully infectious extracellular virus particle." [GOC:bm] is_a: GO:0044423 ! virion part created_by: rfoulger creation_date: 2012-09-07T13:28:21Z [Term] id: GO:0036339 name: lymphocyte adhesion to endothelial cell of high endothelial venule namespace: biological_process def: "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules] comment: For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'. synonym: "lymphocyte adhesion to HEV cell" EXACT [PMID:7679710, Wikipedia:High_endothelial_venules] synonym: "lymphocyte adhesion to high endothelial venule" EXACT [GOC:nhn] is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell created_by: rfoulger creation_date: 2012-09-10T16:00:23Z [Term] id: GO:0036340 name: chitin-based cuticle sclerotization by biomineralization namespace: biological_process def: "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate." [GOC:sart] synonym: "chitin-based cuticle hardening by biomineralisation" EXACT [GOC:bf] is_a: GO:0007593 ! chitin-based cuticle sclerotization is_a: GO:0031214 ! biomineral tissue development created_by: rfoulger creation_date: 2012-09-11T13:50:04Z [Term] id: GO:0036341 name: chitin-based cuticle sclerotization by protein cross-linking namespace: biological_process def: "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle." [GOC:bf, GOC:sart] synonym: "chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning" NARROW [GOC:bf, GOC:dos, GOC:sart] is_a: GO:0007593 ! chitin-based cuticle sclerotization created_by: rfoulger creation_date: 2012-09-11T13:51:46Z [Term] id: GO:0036342 name: post-anal tail morphogenesis namespace: biological_process def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: rfoulger creation_date: 2012-09-11T13:54:49Z [Term] id: GO:0036343 name: psychomotor behavior namespace: biological_process def: "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning] is_a: GO:0061744 ! motor behavior created_by: rfoulger creation_date: 2012-09-11T14:32:06Z [Term] id: GO:0036344 name: platelet morphogenesis namespace: biological_process def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] is_a: GO:0000904 ! cell morphogenesis involved in differentiation created_by: rfoulger creation_date: 2012-09-11T15:15:35Z [Term] id: GO:0036345 name: platelet maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation created_by: rfoulger creation_date: 2012-09-11T15:23:11Z [Term] id: GO:0036346 name: cellular response to L-cysteine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration." [GOC:al] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901367 ! response to L-cysteine created_by: rfoulger creation_date: 2012-09-18T14:21:54Z [Term] id: GO:0036348 name: hydantoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin." [EC:5.1.99.5, InterPro:IPR015942] xref: EC:5.1.99.5 xref: KEGG_REACTION:R09704 xref: MetaCyc:RXN-9781 is_a: GO:0016854 ! racemase and epimerase activity created_by: rfoulger creation_date: 2012-09-19T10:47:56Z [Term] id: GO:0036349 name: galactose-specific flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069] is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: has_part GO:0005534 ! galactose binding created_by: rfoulger creation_date: 2012-09-19T10:56:16Z [Term] id: GO:0036350 name: mannose-specific flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992] is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: has_part GO:0005537 ! mannose binding created_by: rfoulger creation_date: 2012-09-19T10:57:34Z [Term] id: GO:0036351 name: histone H2A-K13 ubiquitination namespace: biological_process def: "The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979] synonym: "histone H2A ubiquitination (H2A-K13)" EXACT [GOC:sp] is_a: GO:0033522 ! histone H2A ubiquitination created_by: rfoulger creation_date: 2012-09-19T11:48:05Z [Term] id: GO:0036352 name: histone H2A-K15 ubiquitination namespace: biological_process def: "The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979] synonym: "histone H2A ubiquitination (H2A-K15)" EXACT [GOC:sp] is_a: GO:0033522 ! histone H2A ubiquitination created_by: rfoulger creation_date: 2012-09-19T11:49:03Z [Term] id: GO:0036353 name: histone H2A-K119 monoubiquitination namespace: biological_process def: "The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022] synonym: "histone H2A monoubiquitination (H2A-K119)" EXACT [GOC:sp] is_a: GO:0035518 ! histone H2A monoubiquitination created_by: rfoulger creation_date: 2012-09-19T11:52:25Z [Term] id: GO:0036354 name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569] xref: MetaCyc:RXN-8787 is_a: GO:0016491 ! oxidoreductase activity relationship: part_of GO:0030494 ! bacteriochlorophyll biosynthetic process created_by: rfoulger creation_date: 2012-09-19T14:46:31Z [Term] id: GO:0036355 name: 2-iminoacetate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671] xref: EC:4.1.99.19 xref: MetaCyc:RXN-11319 xref: RHEA:26361 is_a: GO:0016830 ! carbon-carbon lyase activity relationship: part_of GO:0009228 ! thiamine biosynthetic process created_by: rfoulger creation_date: 2012-09-19T14:52:51Z [Term] id: GO:0036356 name: cyclic 2,3-diphosphoglycerate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate." [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660] comment: This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). synonym: "cDPGS activity" EXACT [PMID:9811660] synonym: "CPGS activity" EXACT [GOC:bf] xref: EC:4.6.1 is_a: GO:0009975 ! cyclase activity relationship: part_of GO:1901369 ! cyclic 2,3-bisphospho-D-glycerate biosynthetic process created_by: rfoulger creation_date: 2012-09-19T14:59:19Z [Term] id: GO:0036357 name: 2-phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP." [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166] comment: This reaction is the first step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). synonym: "2PGK activity" EXACT [GOC:bf] xref: EC:2.7.2 is_a: GO:0016301 ! kinase activity relationship: part_of GO:1901369 ! cyclic 2,3-bisphospho-D-glycerate biosynthetic process created_by: rfoulger creation_date: 2012-09-19T15:06:25Z [Term] id: GO:0036358 name: lipoteichoic acid D-alanylation namespace: biological_process def: "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA)." [GOC:crds, PMID:22750871, PMID:8682792] synonym: "D-alanyl lipoteichoic acid formation" EXACT [PMID:8682792] synonym: "D-alanyl LTA formation" EXACT [PMID:8682792] synonym: "LTA D-alanylation" EXACT [PMID:22750871] is_a: GO:0070400 ! teichoic acid D-alanylation created_by: rfoulger creation_date: 2012-09-19T15:09:05Z [Term] id: GO:0036359 name: renal potassium excretion namespace: biological_process def: "The elimination by an organism of potassium in the urine." [GOC:gap, PMID:15034090, PMID:16014448] synonym: "renal K(+) excretion" EXACT [PMID:16014448] synonym: "renal K+ elimination" EXACT [PMID:15034090] synonym: "renal potassium ion excretion" EXACT [GOC:bf] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion created_by: rfoulger creation_date: 2012-09-20T11:10:47Z [Term] id: GO:0036360 name: sorocarp stalk morphogenesis namespace: biological_process def: "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDANAT:0000068, GOC:pf, PMID:22902739] synonym: "fruiting body stalk morphogenesis" BROAD [DDANAT:0000068] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0031150 ! sorocarp stalk development relationship: part_of GO:0031288 ! sorocarp morphogenesis created_by: rfoulger creation_date: 2012-09-20T11:21:30Z [Term] id: GO:0036361 name: racemase activity, acting on amino acids and derivatives namespace: molecular_function def: "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative." [GOC:crds] is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives created_by: rfoulger creation_date: 2012-09-21T11:13:47Z [Term] id: GO:0036362 name: ascus membrane namespace: cellular_component def: "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi." [GOC:mcc, GOC:vw, PMID:21900489] is_a: GO:0016020 ! membrane created_by: rfoulger creation_date: 2012-09-21T11:21:41Z [Term] id: GO:0036363 name: transforming growth factor beta activation namespace: biological_process def: "The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms." [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210] synonym: "L-TGF-beta activation" EXACT [PMID:2070685] synonym: "latent TGF-beta activation" EXACT [PMID:2070685] synonym: "TGF-B activation" EXACT [GOC:sl] synonym: "TGF-beta activation" EXACT [PR:000000046] synonym: "TGFB activation" EXACT [GOC:sl] synonym: "TGFbeta activation" EXACT [GOC:bf] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0071604 ! transforming growth factor beta production created_by: rfoulger creation_date: 2012-09-24T10:06:56Z [Term] id: GO:0036364 name: transforming growth factor beta1 activation namespace: biological_process def: "The release of transforming growth factor beta1 (TGF-beta1) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] synonym: "L-TGF-beta 1 activation" EXACT [PMID:2070685] synonym: "latent-TGF-beta1 activation" EXACT [PMID:19439069] synonym: "TGF-beta 1 activation" EXACT [PR:000000182] synonym: "TGFB1 activation" EXACT [PR:000000182] synonym: "TGFbeta 1 activation" EXACT [GOC:bf] synonym: "transforming growth factor-beta1 activation" EXACT [PMID:19513812] is_a: GO:0036363 ! transforming growth factor beta activation relationship: part_of GO:0032905 ! transforming growth factor beta1 production created_by: rfoulger creation_date: 2012-09-24T10:09:02Z [Term] id: GO:0036365 name: transforming growth factor beta2 activation namespace: biological_process def: "The release of transforming growth factor beta 2 (TGF-beta2) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] synonym: "TGF-beta 2 activation" EXACT [PR:000000183] synonym: "TGFB2 activation" EXACT [PR:000000183] synonym: "TGFbeta 2 activation" EXACT [GOC:bf] is_a: GO:0036363 ! transforming growth factor beta activation relationship: part_of GO:0032906 ! transforming growth factor beta2 production created_by: rfoulger creation_date: 2012-09-24T10:15:11Z [Term] id: GO:0036366 name: transforming growth factor beta3 activation namespace: biological_process def: "The release of transforming growth factor beta 3 (TGF-beta3) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] synonym: "TGF-beta 3 activation" EXACT [PR:000000184] synonym: "TGFB3 activation" EXACT [PR:000000184] synonym: "TGFbeta 3 activation" EXACT [GOC:bf] is_a: GO:0036363 ! transforming growth factor beta activation relationship: part_of GO:0032907 ! transforming growth factor beta3 production created_by: rfoulger creation_date: 2012-09-24T10:16:05Z [Term] id: GO:0036367 name: light adaption namespace: biological_process def: "The ability of a photoreceptor to adjust to varying levels of light." [GOC:gap, PMID:16039565] comment: Light adaptation is usually a combination of cell desensitization and response acceleration. is_a: GO:0009642 ! response to light intensity created_by: rfoulger creation_date: 2012-09-26T13:28:14Z [Term] id: GO:0036368 name: cone photoresponse recovery namespace: biological_process def: "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers." [GOC:gap, PMID:16039565, PMID:22802362] synonym: "cone phototransduction termination" RELATED [GOC:bf] synonym: "cone response recovery" EXACT [PMID:12732716] is_a: GO:0009416 ! response to light stimulus created_by: rfoulger creation_date: 2012-09-26T14:35:20Z [Term] id: GO:0036369 name: transcription factor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:al, GOC:vw, PMID:22833559] synonym: "proteasome-mediated transcription factor catabolism" EXACT [GOC:bf] synonym: "sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:bf] synonym: "transcription factor breakdown" EXACT [GOC:bf] synonym: "transcription factor catabolism" EXACT [GOC:bf] synonym: "transcription factor degradation" EXACT [PMID:22833559] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: rfoulger creation_date: 2012-10-05T10:53:55Z [Term] id: GO:0036370 name: D-alanyl carrier activity namespace: molecular_function def: "Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)." [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792] synonym: "D-alanyl carrier protein" RELATED [GOC:crds, PMID:11222605] is_a: GO:0000036 ! acyl carrier activity intersection_of: GO:0000036 ! acyl carrier activity intersection_of: part_of GO:0070400 ! teichoic acid D-alanylation relationship: part_of GO:0070400 ! teichoic acid D-alanylation created_by: rfoulger creation_date: 2012-10-08T10:30:33Z [Term] id: GO:0036371 name: protein localization to T-tubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:BHF, GOC:rl, PMID:16292983] synonym: "protein localisation to T-tubule" EXACT [GOC:rl] synonym: "protein localization to T tubule" EXACT [GOC:rl] synonym: "protein localization to transverse tubule" EXACT [GOC:rl] is_a: GO:0072659 ! protein localization to plasma membrane created_by: rfoulger creation_date: 2012-10-08T17:10:29Z [Term] id: GO:0036372 name: opsin transport namespace: biological_process def: "The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:atm, PMID:20238016, PMID:22855808] synonym: "ciliary transport of opsin" NARROW [GOC:20238016] is_a: GO:0015031 ! protein transport created_by: rfoulger creation_date: 2013-04-23T09:26:29Z [Term] id: GO:0036373 name: L-fucose mutarotase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-fucose = beta-L-fucose." [GOC:crds, PMID:15060078, RHEA:25580] synonym: "alpha-L-fucose 1-epimerase activity" EXACT [EC:5.1.3.29] synonym: "fucose 1-epimerase activity" EXACT [EC:5.1.3.29] synonym: "type-2 mutarotase activity" EXACT [EC:5.1.3.29] xref: EC:5.1.3.29 xref: MetaCyc:RXN0-5298 xref: RHEA:25580 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives created_by: rfoulger creation_date: 2013-05-07T09:51:06Z [Term] id: GO:0036374 name: glutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk] synonym: "gamma-glutamyltranspeptidase activity" EXACT [EC:3.4.19.13] synonym: "glutathionase activity" EXACT [EC:3.4.19.13] xref: EC:3.4.19.13 xref: KEGG_REACTION:R00494 xref: MetaCyc:RXN-12618 xref: Reactome:R-HSA-1222712 "Nitrosoglutathione gets cleaved to Cys(NO)-Gly" xref: Reactome:R-HSA-266046 "GGT1, 5 dimers hydrolyse LTC4 to LTD4" xref: Reactome:R-HSA-5433072 "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG" xref: Reactome:R-HSA-5602984 "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG" xref: Reactome:R-HSA-8943279 "GGT dimers hydrolyse GSH" xref: Reactome:R-HSA-9026757 "GGT hydrolyses MCTR1 to MCTR2" xref: Reactome:R-HSA-9026907 "GGT hydrolyses PCTR2 to PCTR3" xref: Reactome:R-HSA-9026912 "GGT hydrolyses PCTR1 to PCTR2" xref: Reactome:R-HSA-9026916 "GGT hydrolyses RCTR2 to RCTR3" xref: Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2" xref: Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH" xref: RHEA:28807 is_a: GO:0008242 ! omega peptidase activity created_by: rfoulger creation_date: 2013-05-07T09:58:07Z [Term] id: GO:0036375 name: Kibra-Ex-Mer complex namespace: cellular_component def: "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598] synonym: "Kbr, Ex and Mer complex" EXACT [PMID:20159598] synonym: "KEM complex" EXACT [PMID:20159598] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0045177 ! apical part of cell created_by: rfoulger creation_date: 2013-05-07T10:05:15Z [Term] id: GO:0036376 name: sodium ion export across plasma membrane namespace: biological_process alt_id: GO:0071436 alt_id: GO:0098667 def: "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:14674689] synonym: "sodium export" RELATED [GOC:mah] synonym: "sodium ion export" RELATED [] synonym: "sodium ion export from cell" EXACT [] is_a: GO:0035725 ! sodium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: midori creation_date: 2009-12-16T11:13:55Z [Term] id: GO:0036377 name: arbuscular mycorrhizal association namespace: biological_process def: "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil." [GOC:sk, Wikipedia:Arbuscular_mycorrhiza] synonym: "arbuscular mycorrhizae formation" EXACT [Wikipedia:Arbuscular_mycorrhiza] synonym: "arbuscular mycorrhizal symbiosis" RELATED [Wikipedia:Arbuscular_mycorrhiza] synonym: "arbuscular mycorrhizas formation" EXACT [Wikipedia:Arbuscular_mycorrhiza] is_a: GO:0044403 ! symbiotic process created_by: rfoulger creation_date: 2013-05-07T15:07:32Z [Term] id: GO:0036378 name: calcitriol biosynthetic process from calciol namespace: biological_process def: "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol." [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049] synonym: "1alpha,25(OH)2D3 biosynthesis" BROAD [CHEBI:17823] synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823] synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823] synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf] synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042368 ! vitamin D biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0070640 ! vitamin D3 metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process created_by: rfoulger creation_date: 2013-05-15T11:46:08Z [Term] id: GO:0036379 name: myofilament namespace: cellular_component def: "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] synonym: "striated muscle filament" EXACT [GOC:bf] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030016 ! myofibril created_by: rfoulger creation_date: 2013-05-22T14:39:06Z [Term] id: GO:0036380 name: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.33, GOC:rs] synonym: "GlcNAc-P-P-Und synthase activity" EXACT [EC:2.7.8.33] synonym: "UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity" EXACT [EC:2.7.8.33] synonym: "UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.33] synonym: "UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.33] synonym: "UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.33] xref: EC:2.7.8.33 xref: KEGG_REACTION:R08856 xref: MetaCyc:GLCNACPTRANS-RXN xref: RHEA:28090 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups created_by: rfoulger creation_date: 2013-05-23T10:51:26Z [Term] id: GO:0036381 name: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate." [EC:4.3.3.6, GOC:rs] synonym: "PdxST activity" EXACT [EC:4.3.3.6] synonym: "pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity" EXACT [EC:4.3.3.6] xref: EC:4.3.3.6 xref: KEGG_REACTION:R10089 xref: MetaCyc:RXN-11322 xref: RHEA:31507 is_a: GO:0016843 ! amine-lyase activity created_by: rfoulger creation_date: 2013-05-23T11:15:37Z [Term] id: GO:0036382 name: flavin reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: reduced flavin + NAD+ = flavin + NADH + H+." [EC:1.5.1.36, GOC:rs] synonym: "flavin:NADH oxidoreductase activity" EXACT [EC:1.5.1.36] synonym: "NADH-dependent flavin reductase activity" EXACT [EC:1.5.1.36] xref: EC:1.5.1.36 xref: KEGG_REACTION:R09662 xref: MetaCyc:1.5.1.36-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2013-05-23T11:23:09Z [Term] id: GO:0036383 name: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O." [EC:1.14.14.12, GOC:rs] xref: EC:1.14.14.12 xref: KEGG_REACTION:R09819 xref: MetaCyc:1.14.14.12-RXN xref: RHEA:31731 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen created_by: rfoulger creation_date: 2013-05-23T11:31:09Z [Term] id: GO:0036384 name: cytidine diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + H2O = CMP + phosphate." [GOC:al] synonym: "CDPase activity" EXACT [GOC:al] is_a: GO:0017110 ! nucleoside-diphosphatase activity created_by: rfoulger creation_date: 2013-05-23T13:33:01Z [Term] id: GO:0036385 name: nucleoid DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm] is_a: GO:0006323 ! DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0009295 ! nucleoid relationship: occurs_in GO:0009295 ! nucleoid created_by: rfoulger creation_date: 2013-05-30T10:36:05Z [Term] id: GO:0036386 name: bacterial nucleoid DNA packaging namespace: biological_process def: "Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520] synonym: "chromosomal compaction" BROAD [PMID:17097674] synonym: "nucleoid compaction" BROAD [PMID:17097674] synonym: "prokaryotic DNA condensation" BROAD [Wikipedia:DNA_condensation] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0043590 ! bacterial nucleoid relationship: occurs_in GO:0043590 ! bacterial nucleoid created_by: rfoulger creation_date: 2013-05-30T10:41:08Z [Term] id: GO:0036387 name: pre-replicative complex namespace: cellular_component def: "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex] comment: This term describes pre-replicative complexes across organisms. synonym: "pre-RC" EXACT [Wikipedia:Pre-replication_complex] synonym: "pre-replication complex" EXACT [Wikipedia:Pre-replication_complex] is_a: GO:0032993 ! protein-DNA complex created_by: rfoulger creation_date: 2013-06-05T16:14:52Z [Term] id: GO:0036388 name: pre-replicative complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-RC assembly" EXACT [Wikipedia:Pre-replication_complex] synonym: "pre-replication complex assembly" RELATED [Wikipedia:Pre-replication_complex] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006261 ! DNA-dependent DNA replication created_by: rfoulger creation_date: 2013-06-05T16:29:13Z [Term] id: GO:0036389 name: bacterial pre-replicative complex namespace: cellular_component def: "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex] synonym: "bacterial pre-RC" EXACT [GOC:bf, GOC:bhm, GOC:jh2] is_a: GO:0036387 ! pre-replicative complex relationship: has_part GO:1990101 ! DnaA-oriC complex created_by: rfoulger creation_date: 2013-06-05T16:41:47Z [Term] id: GO:0036390 name: pre-replicative complex assembly involved in bacterial-type DNA replication namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796] synonym: "bacterial pre-RC assembly" EXACT [GOC:bf, GOC:bhm, GOC:jh2] synonym: "bacterial pre-replicative complex assembly" EXACT [] is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: rfoulger creation_date: 2013-06-05T16:45:21Z [Term] id: GO:0036391 name: medial cortex septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins." [GOC:vw, PMID:16009555] is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0031097 ! medial cortex relationship: part_of GO:0031097 ! medial cortex created_by: rfoulger creation_date: 2013-06-06T16:12:06Z [Term] id: GO:0036392 name: chemokine (C-C motif) ligand 20 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc] synonym: "C-C motif chemokine 20 production" EXACT [] synonym: "CCL-20 production" EXACT [] synonym: "CCL20 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: rfoulger creation_date: 2013-06-17T14:42:07Z [Term] id: GO:0036393 name: thiocyanate peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate." [GOC:pm, PMID:12626341] synonym: "lactoperoxidase activity" BROAD [PMID:12626341, Wikipedia:Lactoperoxidase] is_a: GO:0004601 ! peroxidase activity relationship: part_of GO:0018969 ! thiocyanate metabolic process created_by: rfoulger creation_date: 2013-06-20T16:03:57Z [Term] id: GO:0036394 name: amylase secretion namespace: biological_process def: "The controlled release of amylase from a cell." [GOC:jc, PMID:19028687] synonym: "amylase release" EXACT [PMID:19028687] is_a: GO:0009306 ! protein secretion created_by: rfoulger creation_date: 2013-07-01T13:03:19Z [Term] id: GO:0036395 name: pancreatic amylase secretion namespace: biological_process def: "The controlled release of amylase from a cell of the pancreas." [GOC:jc, PMID:19028687] is_a: GO:0036394 ! amylase secretion relationship: part_of GO:0030157 ! pancreatic juice secretion created_by: rfoulger creation_date: 2013-07-01T13:42:34Z [Term] id: GO:0036396 name: RNA N6-methyladenosine methyltransferase complex namespace: cellular_component def: "A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B)." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716] synonym: "m(6)A writer complex" RELATED [] synonym: "m6A methyltransferase complex" RELATED [] synonym: "METTL3-METTL14-WTAP methyltransferase complex" RELATED [] synonym: "MIS complex" RELATED [] synonym: "Mum2, Ime4, and Slz1 complex" EXACT [PMID:22685417] synonym: "WMM complex" EXACT [] is_a: GO:0034708 ! methyltransferase complex is_a: GO:0045293 ! mRNA editing complex created_by: rfoulger creation_date: 2013-07-15T10:17:50Z [Term] id: GO:0036397 name: formate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: formate + a quinone = CO2 + a quinol." [EC:1.1.5.6, GOC:bhm] synonym: "Fdh-N activity" RELATED [EC:1.1.5.6] synonym: "formate dehydrogenase-N activity" RELATED [EC:1.1.5.6] synonym: "formate:quinone oxidoreductase activity" EXACT [EC:1.1.5.6] xref: EC:1.1.5.6 xref: KEGG_REACTION:R09494 xref: MetaCyc:FORMATEDEHYDROG-RXN is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor created_by: rfoulger creation_date: 2013-07-18T13:11:41Z [Term] id: GO:0036398 name: TCR signalosome namespace: cellular_component def: "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology." [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112] synonym: "LAT signalosome" EXACT [GOC:krc, PMID:17534068] synonym: "linker for activation of T cells signalosome" EXACT [PMID:17534068] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0042101 ! T cell receptor complex created_by: rfoulger creation_date: 2013-07-18T13:52:24Z [Term] id: GO:0036399 name: TCR signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome." [GOC:krc, PMID:22426112] synonym: "LAT signalosome assembly" EXACT [GOC:krc, PMID:17534068] synonym: "linker for activation of T cells signalosome assembly" EXACT [PMID:17534068] is_a: GO:0065003 ! protein-containing complex assembly created_by: rfoulger creation_date: 2013-07-18T14:02:53Z [Term] id: GO:0036400 name: short neuropeptide F receptor activity namespace: molecular_function def: "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021] comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. synonym: "sNPF receptor activity" EXACT [PMID:12372405, PMID:21440021] is_a: GO:0008188 ! neuropeptide receptor activity created_by: rfoulger creation_date: 2013-07-18T14:46:40Z [Term] id: GO:0036401 name: pyrokinin receptor activity namespace: molecular_function def: "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060] synonym: "PK receptor activity" EXACT [PMID:17065249] is_a: GO:0008188 ! neuropeptide receptor activity created_by: rfoulger creation_date: 2013-07-18T15:10:55Z [Term] id: GO:0036402 name: proteasome-activating ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] synonym: "ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:bf] synonym: "proteasomal ATPase activity" EXACT [GOC:bf] synonym: "proteasome channel gating activity" NARROW [GOC:rb] synonym: "proteasome channel opening activity" NARROW [GOC:rb] is_a: GO:0042623 ! ATPase activity, coupled intersection_of: GO:0042623 ! ATPase activity, coupled intersection_of: part_of GO:1901800 ! positive regulation of proteasomal protein catabolic process relationship: part_of GO:1901800 ! positive regulation of proteasomal protein catabolic process created_by: rfoulger creation_date: 2013-08-12T11:38:20Z [Term] id: GO:0036403 name: arachidonate 8(S)-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.-, GOC:lb, PMID:10625675] comment: This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677. synonym: "8(S)-lipoxygenase activity" BROAD [GOC:bf] synonym: "8-lipoxygenase (S-type)" BROAD [KEGG_REACTION:R07053] xref: EC:1.13.11 xref: KEGG_REACTION:R07053 xref: RHEA:38675 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen created_by: rfoulger creation_date: 2013-08-14T11:48:46Z [Term] id: GO:0036404 name: conversion of ds siRNA to ss siRNA namespace: biological_process def: "The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA)." [GOC:vw] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA." RELATED [GOC:bf] is_a: GO:0006396 ! RNA processing relationship: part_of GO:0031050 ! dsRNA processing created_by: rfoulger creation_date: 2013-08-14T14:24:19Z [Term] id: GO:0036405 name: anchored component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:md] synonym: "anchored to cell outer membrane" NARROW [] is_a: GO:0031225 ! anchored component of membrane is_a: GO:0031230 ! intrinsic component of cell outer membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0009279 ! cell outer membrane created_by: rfoulger creation_date: 2013-08-15T11:40:41Z [Term] id: GO:0036406 name: anchored component of periplasmic side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only." [GOC:dos, GOC:md] synonym: "anchored to internal side of cell outer membrane" EXACT [] synonym: "anchored to periplasmic side of cell outer membrane" NARROW [] is_a: GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane is_a: GO:0036405 ! anchored component of cell outer membrane intersection_of: GO:0036405 ! anchored component of cell outer membrane intersection_of: part_of GO:0031241 ! periplasmic side of cell outer membrane created_by: rfoulger creation_date: 2013-08-15T11:45:39Z [Term] id: GO:0036407 name: mycolate outer membrane namespace: cellular_component def: "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria)." [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661] synonym: "MOM" EXACT [GOC:md] synonym: "mycobacterial outer membrane" EXACT [GOC:md] synonym: "mycolate outer membrane" NARROW [GOC:md] synonym: "mycomembrane" EXACT [GOC:das, GOC:md] is_a: GO:0009279 ! cell outer membrane created_by: rfoulger creation_date: 2013-08-15T13:33:46Z [Term] id: GO:0036408 name: histone acetyltransferase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)." [GOC:vw, PMID:21289066] synonym: "histone lysine N-acetyltransferase activity (H3-K14 specific)" EXACT [GOC:bf] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0044154 ! histone H3-K14 acetylation created_by: rfoulger creation_date: 2013-08-21T10:03:10Z [Term] id: GO:0036409 name: histone H3-K14 acetyltransferase complex namespace: cellular_component def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3." [GOC:vw, PMID:21289066] synonym: "H3-K14 histone acetyltransferase complex" EXACT [GOC:bf] synonym: "histone acetyltransferase complex (H3-K14 specific)" EXACT [GOC:bf] synonym: "histone H3 Lys 14 (H3K14) acetyltransferase complex" EXACT [PMID:21289066] synonym: "histone H3K14 acetyltransferase complex" EXACT [PMID:21289066] is_a: GO:0070775 ! H3 histone acetyltransferase complex created_by: rfoulger creation_date: 2013-08-21T10:06:34Z [Term] id: GO:0036410 name: Mst2 histone acetyltransferase complex namespace: cellular_component def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6." [GOC:vw, PMID:21289066] synonym: "Mst2 complex" EXACT [PMID:21289066] synonym: "Mst2 H3K14 acetyltransferase complex" EXACT [PMID:21289066] synonym: "Mst2 histone H3K14 acetyltransferase complex" EXACT [PMID:21289066] is_a: GO:0036409 ! histone H3-K14 acetyltransferase complex created_by: rfoulger creation_date: 2013-08-21T10:11:32Z [Term] id: GO:0036411 name: H-NS-Cnu complex namespace: cellular_component def: "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:18189420, PMID:22358512] is_a: GO:0090569 ! cytoplasmic transcriptional repressor complex relationship: has_part GO:1990121 ! H-NS complex relationship: part_of GO:0005829 ! cytosol created_by: rfoulger creation_date: 2013-08-22T10:19:24Z [Term] id: GO:0036412 name: acetyl-CoA:oxalate CoA-transferase namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA." [GOC:imk, PMID:23935849] xref: RHEA:37883 is_a: GO:0008410 ! CoA-transferase activity created_by: rfoulger creation_date: 2013-08-22T13:43:25Z [Term] id: GO:0036413 name: histone H3-R26 citrullination namespace: biological_process def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3." [GOC:als, PMID:22853951] synonym: "histone H3 arginine 26 citrullination" EXACT [GOC:als] is_a: GO:0036414 ! histone citrullination created_by: rfoulger creation_date: 2013-08-22T13:59:15Z [Term] id: GO:0036414 name: histone citrullination namespace: biological_process def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein." [GOC:als, PMID:22853951, PMID:23175390] synonym: "histone deimination" EXACT [Wikipedia:Citrullination] is_a: GO:0016570 ! histone modification is_a: GO:0018101 ! protein citrullination created_by: rfoulger creation_date: 2013-08-22T14:04:26Z [Term] id: GO:0036415 name: regulation of tRNA stability namespace: biological_process def: "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs." [GOC:aa, PMID:21502523, PMID:23572593] is_a: GO:0043487 ! regulation of RNA stability is_a: GO:1902370 ! regulation of tRNA catabolic process created_by: rfoulger creation_date: 2013-08-22T15:22:13Z [Term] id: GO:0036416 name: tRNA stabilization namespace: biological_process def: "Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084] is_a: GO:0036415 ! regulation of tRNA stability is_a: GO:0043489 ! RNA stabilization is_a: GO:1902371 ! negative regulation of tRNA catabolic process created_by: rfoulger creation_date: 2013-08-22T15:41:26Z [Term] id: GO:0036417 name: tRNA destabilization namespace: biological_process def: "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes." [GOC:aa, GOC:bf] is_a: GO:0036415 ! regulation of tRNA stability is_a: GO:0050779 ! RNA destabilization is_a: GO:1902372 ! positive regulation of tRNA catabolic process created_by: rfoulger creation_date: 2013-08-22T15:43:13Z [Term] id: GO:0036418 name: intrinsic component of mycolate outer membrane namespace: cellular_component def: "The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:md] synonym: "intrinsic to MOM" EXACT [GOC:md] synonym: "intrinsic to mycolate outer membrane" NARROW [] synonym: "intrinsic to mycomembrane" EXACT [GOC:das, GOC:md] is_a: GO:0031230 ! intrinsic component of cell outer membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0036407 ! mycolate outer membrane relationship: part_of GO:0036407 ! mycolate outer membrane created_by: rfoulger creation_date: 2013-09-05T20:19:04Z [Term] id: GO:0036419 name: integral component of mycolate outer membrane namespace: cellular_component def: "The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:md] synonym: "integral to MOM" EXACT [GOC:md] synonym: "integral to mycolate outer membrane" NARROW [] synonym: "integral to mycomembrane" EXACT [GOC:das, GOC:md] is_a: GO:0036418 ! intrinsic component of mycolate outer membrane is_a: GO:0045203 ! integral component of cell outer membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0036407 ! mycolate outer membrane created_by: rfoulger creation_date: 2013-09-05T20:20:04Z [Term] id: GO:0036420 name: extrinsic component of mycolate outer membrane namespace: cellular_component def: "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:md] synonym: "extrinsic to MOM" EXACT [GOC:md] synonym: "extrinsic to mycolate outer membrane" NARROW [] synonym: "extrinsic to mycomembrane" EXACT [GOC:das, GOC:md] is_a: GO:0031244 ! extrinsic component of cell outer membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0036407 ! mycolate outer membrane relationship: part_of GO:0036407 ! mycolate outer membrane created_by: rfoulger creation_date: 2013-09-05T20:22:02Z [Term] id: GO:0036421 name: extrinsic component of external side of mycolate outer membrane namespace: cellular_component def: "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:md] synonym: "extrinsic to external side of MOM" EXACT [GOC:md] synonym: "extrinsic to external side of mycolate outer membrane" NARROW [] synonym: "extrinsic to external side of mycomembrane" EXACT [GOC:das, GOC:md] is_a: GO:0031242 ! extrinsic component of external side of cell outer membrane is_a: GO:0036420 ! extrinsic component of mycolate outer membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098568 ! external side of mycolate outer membrane relationship: part_of GO:0098568 ! external side of mycolate outer membrane created_by: rfoulger creation_date: 2013-09-05T20:23:45Z [Term] id: GO:0036422 name: heptaprenyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30, RHEA:27794] synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "HepPP synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] xref: EC:2.5.1.30 xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN xref: RHEA:27794 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: rfoulger creation_date: 2013-09-16T11:50:41Z [Term] id: GO:0036423 name: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity namespace: molecular_function def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.83, RHEA:27559] synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83] synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83] xref: EC:2.5.1.83 xref: KEGG_REACTION:R09245 xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN xref: RHEA:27559 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: rfoulger creation_date: 2013-09-16T12:22:10Z [Term] id: GO:0036424 name: L-phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-serine + H2O <=> L-serine + phosphate." [RHEA:21208] xref: KEGG_REACTION:R00582 xref: MetaCyc:RXN0-5114 xref: RHEA:21208 is_a: GO:0004647 ! phosphoserine phosphatase activity created_by: rfoulger creation_date: 2013-09-16T13:01:03Z [Term] id: GO:0036425 name: D-phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-D-serine + H2O <=> L-serine + phosphate." [RHEA:24873] xref: KEGG_REACTION:R02853 xref: RHEA:24873 is_a: GO:0004647 ! phosphoserine phosphatase activity created_by: rfoulger creation_date: 2013-09-16T13:02:43Z [Term] id: GO:0036426 name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [RHEA:28118] xref: KEGG_REACTION:R07257 xref: MetaCyc:2.4.1.54-RXN xref: RHEA:28118 is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity created_by: rfoulger creation_date: 2013-09-16T13:21:01Z [Term] id: GO:0036427 name: all-trans-undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:12784] xref: RHEA:12784 is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity created_by: rfoulger creation_date: 2013-09-16T13:23:06Z [Term] id: GO:0036428 name: adenosylcobinamide kinase (GTP-specific) activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+." [RHEA:15765] xref: KEGG_REACTION:R06558 xref: MetaCyc:RXN-14063 xref: RHEA:15765 is_a: GO:0043752 ! adenosylcobinamide kinase activity created_by: rfoulger creation_date: 2013-09-16T14:05:39Z [Term] id: GO:0036429 name: adenosylcobinamide kinase (ATP-specific) activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+." [RHEA:15769] xref: KEGG_REACTION:R05221 xref: MetaCyc:COBINAMIDEKIN-RXN xref: RHEA:15769 is_a: GO:0043752 ! adenosylcobinamide kinase activity created_by: rfoulger creation_date: 2013-09-16T14:05:56Z [Term] id: GO:0036430 name: CMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CMP = ADP + CDP." [RHEA:11600] xref: KEGG_REACTION:R00512 xref: MetaCyc:RXN-11832 xref: RHEA:11600 is_a: GO:0004127 ! cytidylate kinase activity created_by: rfoulger creation_date: 2013-09-16T14:11:48Z [Term] id: GO:0036431 name: dCMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dCMP = ADP + dCDP." [RHEA:25094] synonym: "ATP:dCMP phosphotransferase activity" EXACT [KEGG_REACTION:R01665] xref: KEGG_REACTION:R01665 xref: MetaCyc:RXN-11831 xref: MetaCyc:RXN-7913 xref: RHEA:25094 is_a: GO:0004127 ! cytidylate kinase activity created_by: rfoulger creation_date: 2013-09-16T14:11:56Z [Term] id: GO:0036432 name: all-trans undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+." [RHEA:23752] xref: RHEA:23752 is_a: GO:0009038 ! undecaprenol kinase activity created_by: rfoulger creation_date: 2013-09-16T14:21:04Z [Term] id: GO:0036433 name: di-trans, poly-cis-undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+." [RHEA:28122] synonym: "ditrans,polycis-undecaprenol kinase activity" RELATED [] xref: KEGG_REACTION:R05626 xref: MetaCyc:UNDECAPRENOL-KINASE-RXN xref: RHEA:28122 is_a: GO:0009038 ! undecaprenol kinase activity created_by: rfoulger creation_date: 2013-09-16T14:21:12Z [Term] id: GO:0036434 name: nitronate monooxygenase (FMN-linked) activity namespace: molecular_function def: "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite." [RHEA:26458] xref: KEGG_REACTION:R00025 xref: RHEA:26458 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) created_by: rfoulger creation_date: 2013-09-16T16:20:13Z [Term] id: GO:0036435 name: K48-linked polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein." [GOC:al, PMID:20739285] xref: Reactome:R-HSA-5683077 "RNF8 and RNF168 ubiquitinate KDM4A,B" is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding created_by: rfoulger creation_date: 2013-09-18T14:51:06Z [Term] id: GO:0036436 name: Isw1a complex namespace: cellular_component def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p." [GOC:jd, PMID:12482963] is_a: GO:0016587 ! Isw1 complex created_by: rfoulger creation_date: 2013-09-18T16:45:41Z [Term] id: GO:0036437 name: Isw1b complex namespace: cellular_component def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p." [GOC:jd, PMID:12482963] is_a: GO:0016587 ! Isw1 complex created_by: rfoulger creation_date: 2013-09-18T16:53:07Z [Term] id: GO:0036438 name: maintenance of lens transparency namespace: biological_process def: "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina." [GOC:nhn, PMID:22095752] synonym: "maintenance of ocular lens transparency" EXACT [PMID:22095752] synonym: "preservation of lens transparency" EXACT [PMID:22095752] is_a: GO:0001894 ! tissue homeostasis created_by: rfoulger creation_date: 2013-09-23T13:51:09Z [Term] id: GO:0036440 name: citrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [RHEA:16845] xref: KEGG_REACTION:R00351 xref: RHEA:16845 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer created_by: rfoulger creation_date: 2013-09-30T16:21:50Z [Term] id: GO:0036441 name: 2-dehydropantolactone reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+." [RHEA:18981] xref: KEGG_REACTION:R03155 xref: RHEA:18981 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2013-09-30T16:26:27Z [Term] id: GO:0036443 name: dermatan 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate." [EC:2.8.2.33, GOC:bf, KEGG_REACTION:R07288] xref: KEGG_REACTION:R07288 is_a: GO:0008146 ! sulfotransferase activity created_by: rfoulger creation_date: 2013-10-17T10:41:48Z [Term] id: GO:0036444 name: calcium import into the mitochondrion namespace: biological_process def: "A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix." [GOC:vw] synonym: "calcium ion import into mitochondrion" BROAD [] synonym: "calcium ion transmembrane import into mitochondrion" EXACT [] synonym: "mitochondrial calcium ion import" BROAD [GOC:vw] synonym: "mitochondrial calcium uptake" EXACT [] is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport is_a: GO:0060401 ! cytosolic calcium ion transport is_a: GO:0070509 ! calcium ion import is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: rfoulger creation_date: 2013-10-28T09:32:39Z [Term] id: GO:0036445 name: neuronal stem cell division namespace: biological_process def: "The self-renewing division of a neuronal stem cell." [CL:0000047, GOC:nhn] synonym: "NSC division" EXACT [CL:0000047] is_a: GO:0048103 ! somatic stem cell division created_by: rfoulger creation_date: 2013-10-30T10:03:27Z [Term] id: GO:0036446 name: myofibroblast differentiation namespace: biological_process def: "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn] synonym: "myofibroblast cell differentiation" EXACT [CL:0000186] is_a: GO:0030154 ! cell differentiation created_by: rfoulger creation_date: 2013-10-30T10:06:51Z [Term] id: GO:0036447 name: cellular response to sugar-phosphate stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate." [GOC:am, PMID:17383224] synonym: "cellular response to presence of non-metabolizable sugars" RELATED [GOC:am] is_a: GO:0062197 ! cellular response to chemical stress created_by: rfoulger creation_date: 2013-10-31T11:18:09Z [Term] id: GO:0036448 name: cellular response to glucose-phosphate stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate." [GOC:am, PMID:17383224] is_a: GO:0036447 ! cellular response to sugar-phosphate stress created_by: rfoulger creation_date: 2013-10-31T11:20:08Z [Term] id: GO:0036449 name: microtubule minus-end namespace: cellular_component def: "The end of a microtubule that does not preferentially grow (polymerize)." [GOC:lb, PMID:23169647] synonym: "microtubule minus end" EXACT [GOC:lb] is_a: GO:1990752 ! microtubule end created_by: rfoulger creation_date: 2013-10-31T13:26:51Z [Term] id: GO:0036450 name: polyuridylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462] synonym: "uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GOC:vw] is_a: GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: part_of GO:1990074 ! polyuridylation-dependent mRNA catabolic process created_by: rfoulger creation_date: 2013-11-04T11:37:28Z [Term] id: GO:0036451 name: cap mRNA methylation namespace: biological_process def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA." [GOC:bf, PMID:20713356] is_a: GO:0080009 ! mRNA methylation created_by: rfoulger creation_date: 2013-11-06T14:36:00Z [Term] id: GO:0036452 name: ESCRT complex namespace: cellular_component def: "An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536] synonym: "endosomal sorting complex required for transport" EXACT [PMID:22718754] xref: Wikipedia:ESCRT is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005768 ! endosome created_by: rfoulger creation_date: 2013-11-06T16:25:52Z [Term] id: GO:0036453 name: transitive RNA interference namespace: biological_process def: "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430] synonym: "transitive RNAi" EXACT [PMID:12554873] is_a: GO:0016246 ! RNA interference created_by: rfoulger creation_date: 2013-11-07T11:14:03Z [Term] id: GO:0036454 name: growth factor complex namespace: cellular_component def: "A protein complex that has growth factor activity." [GOC:bhm] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2013-11-07T11:27:16Z [Term] id: GO:0036455 name: iron-sulfur transferase activity namespace: molecular_function def: "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)." [GOC:bhm] synonym: "Fe-S transferase activity" EXACT [GOC:bf] xref: Reactome:R-HSA-2564828 "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups created_by: rfoulger creation_date: 2013-11-14T11:17:37Z [Term] id: GO:0036456 name: L-methionine-(S)-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O." [GOC:vw, RHEA:19995] xref: RHEA:19995 is_a: GO:0033744 ! L-methionine:thioredoxin-disulfide S-oxidoreductase activity created_by: rfoulger creation_date: 2013-11-27T11:07:19Z [Term] id: GO:0036457 name: keratohyalin granule namespace: cellular_component def: "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: rfoulger creation_date: 2013-12-09T13:04:09Z [Term] id: GO:0036458 name: hepatocyte growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [PR:000008534] synonym: "HGF binding" EXACT [PR:000008534] is_a: GO:0019838 ! growth factor binding created_by: rfoulger creation_date: 2013-12-09T14:07:20Z [Term] id: GO:0036459 name: thiol-dependent ubiquitinyl hydrolase activity namespace: molecular_function def: "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka] comment: 20160208: Renamed to thiol-dependent ubiquitinyl hydrolase activity synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12] synonym: "ubiquitinyl hydrolase 1 activity" EXACT [EC:3.4.19.12] synonym: "ubiquitinyl hydrolase activity" BROAD [] xref: EC:3.4.19.12 xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2" xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains" xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2" xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN" xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4" xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53" xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B" xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin" xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A" xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58" xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128" xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts" xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1" xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex" xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A" xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1" xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58" xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR" xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG" xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins" xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC" xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB" xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB" xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20" xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B" xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2" xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2" xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2" xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1" xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10" xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123" xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA" xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR" xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS" xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3" xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33" xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4" xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin" xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb" xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6" xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN" xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin" xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin" is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity is_a: GO:0101005 ! ubiquitinyl hydrolase activity created_by: rfoulger creation_date: 2013-12-19T09:39:38Z [Term] id: GO:0036460 name: cellular response to cell envelope stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope." [GOC:imk, PMID:15101969, PMID:15882407] synonym: "envelope stress response" EXACT [PMID:15882407] is_a: GO:0033554 ! cellular response to stress created_by: rfoulger creation_date: 2014-01-08T15:15:50Z [Term] id: GO:0036461 name: BLOC-2 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules." [GOC:bf, GOC:PARL, PMID:22511774] is_a: GO:0044877 ! protein-containing complex binding created_by: rebeccafoulger creation_date: 2014-06-11T09:14:55Z [Term] id: GO:0036462 name: TRAIL-activated apoptotic signaling pathway namespace: biological_process def: "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface." [GOC:bf, GOC:PARL, PMID:21785459] synonym: "TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "TRAIL-induced apoptotic signaling pathway" EXACT [PMID:21785459] synonym: "tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [PMID:21785459] is_a: GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors created_by: rebeccafoulger creation_date: 2014-06-11T09:18:41Z [Term] id: GO:0036463 name: TRAIL receptor activity namespace: molecular_function def: "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." [GOC:bf, GOC:PARL] synonym: "tumor necrosis factor-related apoptosis-inducing ligand receptor" EXACT [PMID:21785459] is_a: GO:0005035 ! death receptor activity relationship: has_part GO:0045569 ! TRAIL binding relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway created_by: rebeccafoulger creation_date: 2014-06-11T09:20:30Z [Term] id: GO:0036464 name: cytoplasmic ribonucleoprotein granule namespace: cellular_component def: "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] synonym: "Staufen granule" NARROW [PMID:15121898] is_a: GO:0035770 ! ribonucleoprotein granule intersection_of: GO:0035770 ! ribonucleoprotein granule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm created_by: rebeccafoulger creation_date: 2014-06-18T09:44:44Z [Term] id: GO:0036465 name: synaptic vesicle recycling namespace: biological_process def: "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563] synonym: "kiss-and-run synaptic vesicle recycling" NARROW [PMID:15217342] synonym: "kiss-and-stay synaptic vesicle recycling" NARROW [PMID:152127342] is_a: GO:0006810 ! transport relationship: part_of GO:0099504 ! synaptic vesicle cycle created_by: rebeccafoulger creation_date: 2014-06-26T11:03:08Z [Term] id: GO:0036466 name: synaptic vesicle recycling via endosome namespace: biological_process alt_id: GO:0099090 def: "Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342] subset: goslim_synapse synonym: "recycling endosome localization within postsynapse" EXACT [] is_a: GO:0036465 ! synaptic vesicle recycling is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing created_by: rebeccafoulger creation_date: 2014-06-26T11:07:46Z [Term] id: GO:0036467 name: 5-hydroxy-L-tryptophan decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin." [GOC:bf, GOC:PARL, RHEA:18533] synonym: "5-hydroxytryptophan decarboxylase activity" BROAD [EC:4.1.1.28] xref: RHEA:18533 is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity created_by: rebeccafoulger creation_date: 2014-07-21T09:22:24Z [Term] id: GO:0036468 name: L-dopa decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine." [GOC:bf, GOC:PARL, RHEA:12272] synonym: "4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [PMID:19703902] synonym: "DDC activity" EXACT [PMID:19703902] synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] xref: RHEA:12272 is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity created_by: rebeccafoulger creation_date: 2014-07-21T09:22:24Z [Term] id: GO:0036469 name: L-tryptophan decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine." [GOC:bf, GOC:PARL, RHEA:30339] synonym: "L-tryptophan decarboxylase activity" EXACT [EC:4.1.1.105] xref: EC:4.1.1.105 xref: RHEA:30339 is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity created_by: rebeccafoulger creation_date: 2014-07-21T09:22:24Z [Term] id: GO:0036470 name: tyrosine 3-monooxygenase activator activity namespace: molecular_function def: "Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity." [GOC:bf, GOC:PARL, PMID:19703902] synonym: "TH activator activity" EXACT [PMID:19703902] synonym: "tyrosine hydroxylase activator activity" EXACT [PMID:19703902] is_a: GO:0008047 ! enzyme activator activity relationship: part_of GO:1903178 ! positive regulation of tyrosine 3-monooxygenase activity relationship: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity created_by: rebeccafoulger creation_date: 2014-07-21T11:06:49Z [Term] id: GO:0036471 name: cellular response to glyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus." [GOC:bf, GOC:PARL] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0110096 ! cellular response to aldehyde created_by: rebeccafoulger creation_date: 2014-07-21T11:14:33Z [Term] id: GO:0036472 name: suppression by virus of host protein-protein interaction namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins." [GOC:bf, GOC:PARL, PMID:17297443] synonym: "suppression by virus of host protein binding" EXACT [GOC:bf] synonym: "suppression by virus of host protein interaction" EXACT [GOC:bf] synonym: "suppression by virus of host protein:protein binding" EXACT [GOC:bf] synonym: "suppression by virus of host protein:protein interaction" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function created_by: rebeccafoulger creation_date: 2014-07-21T11:18:51Z [Term] id: GO:0036473 name: cell death in response to oxidative stress namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred in response to an oxidative stress stimulus, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0097468 'programmed cell death in response to reactive oxygen species'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. is_a: GO:0008219 ! cell death relationship: part_of GO:0034599 ! cellular response to oxidative stress created_by: rebeccafoulger creation_date: 2014-07-21T11:37:03Z [Term] id: GO:0036474 name: cell death in response to hydrogen peroxide namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0010421 'hydrogen peroxide-mediated programmed cell death'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. synonym: "cell death in response to H2O2" EXACT [GOC:bf] synonym: "hydrogen peroxide-mediated cell death" RELATED [GOC:bf] is_a: GO:0036473 ! cell death in response to oxidative stress relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide created_by: rebeccafoulger creation_date: 2014-07-21T11:42:28Z [Term] id: GO:0036475 name: neuron death in response to oxidative stress namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. synonym: "neuronal cell death in response to oxidative stress" EXACT [GOC:bf] synonym: "oxidative stress-induced neuron death" EXACT [GOC:bf] is_a: GO:0036473 ! cell death in response to oxidative stress is_a: GO:0070997 ! neuron death created_by: rebeccafoulger creation_date: 2014-07-21T11:44:40Z [Term] id: GO:0036476 name: neuron death in response to hydrogen peroxide namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. synonym: "hydrogen peroxide-induced neuron death" EXACT [GOC:bf] synonym: "neuron death in response to H2O2" EXACT [GOC:bf] synonym: "neuronal cell death in response to hydrogen peroxide" EXACT [GOC:bf] is_a: GO:0036474 ! cell death in response to hydrogen peroxide is_a: GO:0036475 ! neuron death in response to oxidative stress created_by: rebeccafoulger creation_date: 2014-07-21T11:46:31Z [Term] id: GO:0036477 name: somatodendritic compartment namespace: cellular_component def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] is_a: GO:0110165 ! cellular anatomical entity created_by: rebeccafoulger creation_date: 2014-07-24T10:06:19Z [Term] id: GO:0036478 name: L-dopa decarboxylase activator activity namespace: molecular_function def: "Interacts with and increases L-dopa decarboxylase activity." [GOC:bf, GOC:PARL] comment: GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'. synonym: "DDC activator activity" EXACT [GOC:bf] is_a: GO:0008047 ! enzyme activator activity relationship: part_of GO:1903200 ! positive regulation of L-dopa decarboxylase activity relationship: positively_regulates GO:0036468 ! L-dopa decarboxylase activity created_by: rebeccafoulger creation_date: 2014-07-24T10:10:51Z [Term] id: GO:0036479 name: peroxidase inhibitor activity namespace: molecular_function def: "Interacts with, and stops, prevents or reduces the activity of a peroxidase." [GOC:bf, GOC:PARL] comment: GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'. is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004601 ! peroxidase activity relationship: part_of GO:2000469 ! negative regulation of peroxidase activity created_by: rebeccafoulger creation_date: 2014-07-24T10:14:45Z [Term] id: GO:0036480 name: neuron intrinsic apoptotic signaling pathway in response to oxidative stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059] synonym: "neuron apoptosis in response to oxidative stress" RELATED [GOC:bf] synonym: "oxidative stress-induced neuron apoptosis" BROAD [GOC:bf] synonym: "oxidative stress-induced neuronal apoptosis" BROAD [GOC:bf] is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress relationship: part_of GO:0036475 ! neuron death in response to oxidative stress relationship: part_of GO:0051402 ! neuron apoptotic process created_by: rebeccafoulger creation_date: 2014-08-14T13:13:44Z [Term] id: GO:0036481 name: intrinsic apoptotic signaling pathway in response to hydrogen peroxide namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] synonym: "H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:bf] synonym: "hydrogen peroxide-induced apoptosis" BROAD [GOC:bf] synonym: "hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf] is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress relationship: part_of GO:0010421 ! hydrogen peroxide-mediated programmed cell death created_by: rebeccafoulger creation_date: 2014-08-14T13:19:21Z [Term] id: GO:0036482 name: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide." [GOC:bf, GOC:PARL] synonym: "H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:bf] synonym: "hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:bf] synonym: "neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:bf] synonym: "neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf] is_a: GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress is_a: GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: part_of GO:0036476 ! neuron death in response to hydrogen peroxide created_by: rebeccafoulger creation_date: 2014-08-14T13:23:32Z [Term] id: GO:0036483 name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:bf, GOC:PARL, PMID:21113145] synonym: "endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:bf] synonym: "endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "ER stress-induced neuron apoptosis" BROAD [GOC:bf] synonym: "ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] is_a: GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: part_of GO:0051402 ! neuron apoptotic process created_by: rebeccafoulger creation_date: 2014-08-14T13:33:23Z [Term] id: GO:0036484 name: trunk neural crest cell migration namespace: biological_process def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] synonym: "trunk NCC migration" EXACT [PMID:2387238] is_a: GO:0001755 ! neural crest cell migration relationship: part_of GO:0035290 ! trunk segmentation created_by: rebeccafoulger creation_date: 2014-08-26T15:27:44Z [Term] id: GO:0036485 name: dorsolateral trunk neural crest cell migration namespace: biological_process def: "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] synonym: "dorsolateral trunk NCC migration" EXACT [PMID:2387238] is_a: GO:0036484 ! trunk neural crest cell migration created_by: rebeccafoulger creation_date: 2014-08-26T15:29:04Z [Term] id: GO:0036486 name: ventral trunk neural crest cell migration namespace: biological_process def: "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta." [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662] synonym: "trunk NCC migration through anterior sclerotome" EXACT [PMID:19386662] synonym: "trunk NCC migration within somite" EXACT [GOC:mat] synonym: "ventral trunk NCC migration" EXACT [GOC:bf] is_a: GO:0036484 ! trunk neural crest cell migration created_by: rebeccafoulger creation_date: 2014-08-26T15:30:16Z [Term] id: GO:0036487 name: nitric-oxide synthase inhibitor activity namespace: molecular_function def: "Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase." [GOC:BHF, GOC:rl, PMID:17242280] synonym: "nitric oxide synthase inhibitor activity" EXACT [GOC:bf] synonym: "NOS inhibitor activity" EXACT [GOC:bf] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0030235 ! nitric-oxide synthase regulator activity relationship: negatively_regulates GO:0004517 ! nitric-oxide synthase activity created_by: rebeccafoulger creation_date: 2014-09-09T15:07:20Z [Term] id: GO:0036488 name: CHOP-C/EBP complex namespace: cellular_component def: "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942] synonym: "CHOP-C/EBP dimer" EXACT [PMID:8657121] synonym: "CHOP-C/EBP heterodimer" EXACT [PMID:8657121] synonym: "GADD153-C/EBP complex" EXACT [PMID:8657121] synonym: "GADD153-C/EBP-alpha complex" NARROW [PMID:8657121] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: rebeccafoulger creation_date: 2014-11-06T13:18:49Z [Term] id: GO:0036489 name: neuromelanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers." [GOC:bf, GOC:PARL, Wiki:Neuromelanin] synonym: "neuromelanin anabolism" EXACT [GOC:bf] synonym: "neuromelanin biosynthesis" EXACT [GOC:bf] synonym: "neuromelanin formation" EXACT [GOC:bf] synonym: "neuromelanin synthesis" EXACT [GOC:bf] is_a: GO:0009059 ! macromolecule biosynthetic process created_by: rebeccafoulger creation_date: 2014-11-06T13:21:46Z [Term] id: GO:0036490 name: regulation of translation in response to endoplasmic reticulum stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] synonym: "regulation of translation in response to ER stress" EXACT [GOC:bf] is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0043555 ! regulation of translation in response to stress created_by: rebeccafoulger creation_date: 2015-02-05T09:50:11Z [Term] id: GO:0036491 name: regulation of translation initiation in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] synonym: "regulation of translation initiation in response to ER stress" EXACT [GOC:bf] is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress is_a: GO:0043558 ! regulation of translational initiation in response to stress created_by: rebeccafoulger creation_date: 2015-02-05T09:52:13Z [Term] id: GO:0036492 name: eiF2alpha phosphorylation in response to endoplasmic reticulum stress namespace: biological_process def: "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] synonym: "eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:bf] synonym: "regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf] is_a: GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress created_by: rebeccafoulger creation_date: 2015-02-05T09:53:21Z [Term] id: GO:0036493 name: positive regulation of translation in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] synonym: "positive regulation of translation in response to ER stress" EXACT [GOC:bf] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress created_by: rebeccafoulger creation_date: 2015-02-05T10:09:51Z [Term] id: GO:0036494 name: positive regulation of translation initiation in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] synonym: "positive regulation of translation initiation in response to ER stress" EXACT [GOC:bf] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress is_a: GO:0036493 ! positive regulation of translation in response to endoplasmic reticulum stress created_by: rebeccafoulger creation_date: 2015-02-05T10:11:32Z [Term] id: GO:0036495 name: negative regulation of translation initiation in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] synonym: "negative regulation of translation initiation in response to ER stress" RELATED [GOC:bf] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress is_a: GO:1902010 ! negative regulation of translation in response to endoplasmic reticulum stress created_by: rebeccafoulger creation_date: 2015-02-05T10:13:38Z [Term] id: GO:0036496 name: regulation of translational initiation by eIF2 alpha dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha." [GOC:bf, GOC:PARL] is_a: GO:0006470 ! protein dephosphorylation is_a: GO:0032535 ! regulation of cellular component size is_a: GO:0043558 ! regulation of translational initiation in response to stress created_by: rebeccafoulger creation_date: 2015-02-05T10:21:31Z [Term] id: GO:0036497 name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress namespace: biological_process def: "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:16835242] synonym: "eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:bf] synonym: "regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf] is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress is_a: GO:0036496 ! regulation of translational initiation by eIF2 alpha dephosphorylation created_by: rebeccafoulger creation_date: 2015-02-05T10:24:18Z [Term] id: GO:0036498 name: IRE1-mediated unfolded protein response namespace: biological_process def: "A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210] comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants. synonym: "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:bf] synonym: "ERN1-mediated unfolded protein response" RELATED [HGNC:3449] synonym: "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED [HGNC:3449] synonym: "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [PMID:22013210] synonym: "IRE1 branch of UPR" EXACT [GOC:bf] synonym: "IRE1 signal transduction pathway" BROAD [GOC:bf] synonym: "IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] synonym: "IRE1alpha unfolded protein response" NARROW [PMID:22013210] synonym: "IRE1p unfolded protein response" NARROW [PMID:22013210] synonym: "UPR signaling by IRE1 stress sensor" EXACT [GOC:bf] is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: rebeccafoulger creation_date: 2015-02-05T13:12:12Z [Term] id: GO:0036499 name: PERK-mediated unfolded protein response namespace: biological_process def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210] synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf] synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "PERK branch of UPR" EXACT [GOC:bf] synonym: "PERK signal transduction pathway" BROAD [GOC:bf] synonym: "PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210] synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: rebeccafoulger creation_date: 2015-02-05T13:17:43Z [Term] id: GO:0036500 name: ATF6-mediated unfolded protein response namespace: biological_process def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210] synonym: "activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:bf] synonym: "ATF6 branch of UPR" EXACT [GOC:bf] synonym: "ATF6 signal transduction pathway" BROAD [GOC:bf] synonym: "ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] synonym: "ATF6-alpha UPR branch" NARROW [GOC:bf] synonym: "ATF6-beta UPR branch" NARROW [GOC:bf] synonym: "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:bf] synonym: "UPR signaling by ATF6 stress sensor" EXACT [GOC:bf] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: rebeccafoulger creation_date: 2015-02-05T13:18:58Z [Term] id: GO:0036501 name: UFD1-NPL4 complex namespace: cellular_component def: "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p." [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586] synonym: "Npl4p-Ufd1p complex" EXACT [PMID:17289586] synonym: "Ufd1-Npl4 binary complex" EXACT [PMID:10811609] synonym: "Ufd1-Npl4 cofactor complex" EXACT [PMID:10811609] synonym: "Ufd1/Npl4 complex" EXACT [PMID:10811609] synonym: "UFD1L-NPLOC4 complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: rebeccafoulger creation_date: 2015-05-14T10:59:43Z [Term] id: GO:0036502 name: Derlin-1-VIMP complex namespace: cellular_component def: "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510] synonym: "Derlin-1/VIMP complex" EXACT [PMID:15215856] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: rebeccafoulger creation_date: 2015-05-14T11:40:45Z [Term] id: GO:0036503 name: ERAD pathway namespace: biological_process def: "The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857] comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct. synonym: "endoplasmic reticulum-associated degradation" EXACT [PMID:22535891] synonym: "endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:bf] synonym: "ER-associated degradation pathway" RELATED [PMID:24699081] synonym: "protein degradation by ERAD" EXACT [GOC:bf] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0010498 ! proteasomal protein catabolic process is_a: GO:0034976 ! response to endoplasmic reticulum stress created_by: rebeccafoulger creation_date: 2015-05-14T11:43:06Z [Term] id: GO:0036504 name: Golgi membrane fusion namespace: biological_process def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691] synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf] synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609] is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0090168 ! Golgi reassembly created_by: rebeccafoulger creation_date: 2015-05-21T10:05:06Z [Term] id: GO:0036505 name: prosaposin receptor activity namespace: molecular_function def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493, PR:000031300] synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity created_by: rebeccafoulger creation_date: 2015-06-11T10:13:10Z [Term] id: GO:0036506 name: maintenance of unfolded protein namespace: biological_process def: "Maintaining a protein in an unfolded, soluble state." [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303] is_a: GO:0031647 ! regulation of protein stability created_by: rebeccafoulger creation_date: 2015-06-11T10:17:36Z [Term] id: GO:0036507 name: protein demannosylation namespace: biological_process def: "The removal of one or more mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:25092655] comment: Consider also annotating to the term 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "protein de-mannosylation" EXACT [GOC:bf] is_a: GO:0006517 ! protein deglycosylation relationship: has_part GO:0015923 ! mannosidase activity created_by: rebeccafoulger creation_date: 2015-06-11T13:57:01Z [Term] id: GO:0036508 name: protein alpha-1,2-demannosylation namespace: biological_process def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655] comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "glycoprotein mannose trimming" RELATED [GOC:bf] synonym: "mannose trimming" BROAD [PMID:21062743] is_a: GO:0036507 ! protein demannosylation relationship: has_part GO:0004571 ! mannosyl-oligosaccharide 1,2-alpha-mannosidase activity created_by: rebeccafoulger creation_date: 2015-06-11T13:58:50Z [Term] id: GO:0036509 name: trimming of terminal mannose on B branch namespace: biological_process def: "The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, KEGG_REACTION:R06722, PMID:22160784] comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2" RELATED [PMID:22160784] synonym: "conversion of M9 to M8B" RELATED [PMID:25092655] synonym: "glycoprotein mannose trimming on B branch" EXACT [GOC:bf] xref: KEGG_REACTION:R06722 is_a: GO:1904380 ! endoplasmic reticulum mannose trimming created_by: rebeccafoulger creation_date: 2015-06-11T14:02:44Z [Term] id: GO:0036510 name: trimming of terminal mannose on C branch namespace: biological_process def: "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:20065073] comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2" RELATED [PMID:20065073] synonym: "conversion of M9 to M8C" RELATED [GOC:bf] synonym: "glycoprotein mannose trimming on C branch" EXACT [GOC:bf] is_a: GO:1904380 ! endoplasmic reticulum mannose trimming created_by: rebeccafoulger creation_date: 2015-06-11T14:10:52Z [Term] id: GO:0036511 name: trimming of first mannose on A branch namespace: biological_process def: "The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701] comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2" RELATED [GOC:bf] synonym: "conversion of M9 to M8A" RELATED [GOC:bf] synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf] is_a: GO:1904380 ! endoplasmic reticulum mannose trimming created_by: rebeccafoulger creation_date: 2015-06-11T14:14:03Z [Term] id: GO:0036512 name: trimming of second mannose on A branch namespace: biological_process def: "The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701] comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. synonym: "conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2" RELATED [GOC:bf] synonym: "conversion of M8A to M7AA" RELATED [GOC:bf] synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf] is_a: GO:1904380 ! endoplasmic reticulum mannose trimming created_by: rebeccafoulger creation_date: 2015-06-11T14:16:40Z [Term] id: GO:0036513 name: Derlin-1 retrotranslocation complex namespace: cellular_component def: "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510] comment: The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process. synonym: "Derlin-1 complex" EXACT [PMID:18555783] synonym: "Derlin-1 protein dislocation complex" EXACT [PMID:18555783] synonym: "Derlin-1 retro-translocation complex" EXACT [GOC:bf] synonym: "Derlin-1 retrotranslocon" EXACT [GOC:bf] synonym: "ERAD protein dislocation complex" EXACT [PMID:18555783] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: rebeccafoulger creation_date: 2015-07-01T10:17:30Z [Term] id: GO:0036514 name: dopaminergic neuron axon guidance namespace: biological_process def: "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308] synonym: "DA axon guidance" EXACT [PMID:23517308] synonym: "dopaminergic axon guidance" EXACT [GOC:bf] synonym: "mdDA axon guidance" EXACT [PMID:21106844] is_a: GO:0007411 ! axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:14:20Z [Term] id: GO:0036515 name: serotonergic neuron axon guidance namespace: biological_process def: "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] synonym: "5-HT axon guidance" EXACT [GOC:bf, PMID:21106844] synonym: "serotonergic axon guidance" EXACT [GOC:bf] is_a: GO:0007411 ! axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:15:54Z [Term] id: GO:0036516 name: chemoattraction of dopaminergic neuron axon namespace: biological_process def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:bf, GOC:PARL, PMID:21106844] synonym: "chemoattraction of DA axon" EXACT [GOC:bf] synonym: "chemoattraction of dopaminergic axon" EXACT [GOC:bf] is_a: GO:0061642 ! chemoattraction of axon intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0036514 ! dopaminergic neuron axon guidance relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:23:11Z [Term] id: GO:0036517 name: chemoattraction of serotonergic neuron axon namespace: biological_process def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] synonym: "chemoattraction of 5-HT axon" EXACT [GOC:bf, PMID:21106844] synonym: "chemoattraction of serotonergic axon" EXACT [GOC:bf] is_a: GO:0061642 ! chemoattraction of axon intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0036515 ! serotonergic neuron axon guidance relationship: part_of GO:0036515 ! serotonergic neuron axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:26:03Z [Term] id: GO:0036518 name: chemorepulsion of dopaminergic neuron axon namespace: biological_process def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308] synonym: "chemorepulsion of DA axon" EXACT [GOC:bf, PMID:23517308] synonym: "chemorepulsion of dopaminergic axon" RELATED [GOC:bf] is_a: GO:0061643 ! chemorepulsion of axon intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0036514 ! dopaminergic neuron axon guidance relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:29:09Z [Term] id: GO:0036519 name: chemorepulsion of serotonergic neuron axon namespace: biological_process def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] synonym: "chemorepulsion of 5-HT axon" EXACT [GOC:bf, PMID:21106844] synonym: "chemorepulsion of serotonergic axon" RELATED [GOC:bf] is_a: GO:0061643 ! chemorepulsion of axon intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0036515 ! serotonergic neuron axon guidance relationship: part_of GO:0036515 ! serotonergic neuron axon guidance created_by: rebeccafoulger creation_date: 2015-12-17T11:31:16Z [Term] id: GO:0036520 name: astrocyte-dopaminergic neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258] synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf] synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258] synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] is_a: GO:0150098 ! glial cell-neuron signaling created_by: rebeccafoulger creation_date: 2016-02-29T14:05:47Z [Term] id: GO:0036521 name: modulation by symbiont of host protein localization to phagocytic vesicle namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] synonym: "modulation by symbiont of host protein localisation to phagosome" RELATED [GOC:bf] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle created_by: rebeccafoulger creation_date: 2016-06-06T14:47:10Z [Term] id: GO:0036522 name: negative regulation by symbiont of host protein localization to phagocytic vesicle namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] synonym: "disruption of host protein localisation to phagosome" EXACT [GOC:bf] synonym: "inhibition of host protein localisation to phagosome" EXACT [GOC:bf] synonym: "suppression of host protein localisation to phagosome" EXACT [GOC:bf] is_a: GO:0036521 ! modulation by symbiont of host protein localization to phagocytic vesicle is_a: GO:1905170 ! negative regulation of protein localization to phagocytic vesicle created_by: rebeccafoulger creation_date: 2016-06-06T14:49:51Z [Term] id: GO:0036523 name: induction by symbiont of host cytokine secretion namespace: biological_process def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of cytokine secretion in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] synonym: "induction by symbiont of host cytokine secretion" RELATED [PMID:25063865] synonym: "positive regulation by symbiont of host cytokine secretion" EXACT [] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0052390 ! induction by symbiont of host innate immune response created_by: rebeccafoulger creation_date: 2016-06-06T14:53:54Z [Term] id: GO:0036524 name: protein deglycase activity namespace: molecular_function def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, MetaCyc:RXN-17630, MetaCyc:RXN-17632, MetaCyc:RXN-17634, PMID:14568004, PMID:25416785, PMID:26873906, RHEA:49548, RHEA:49552, RHEA:49556] synonym: "protein deglycating enzyme" RELATED [PMID:26873906] is_a: GO:0016836 ! hydro-lyase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0036525 ! protein deglycation created_by: rebeccafoulger creation_date: 2016-08-04T10:23:33Z [Term] id: GO:0036525 name: protein deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] comment: Glycation is a non enzymatic covalent addition of a sugar or dicarbonyl (methylglyoxal, glyoxal) to a protein. Deglycation repairs the glycated amino acids. synonym: "glycated protein repair" RELATED [PMID:25416785] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0030091 ! protein repair created_by: rebeccafoulger creation_date: 2016-08-04T10:28:54Z [Term] id: GO:0036526 name: peptidyl-cysteine deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] synonym: "deglycation of N-acetylcysteine" RELATED [PMID:25416785] is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0036525 ! protein deglycation created_by: rebeccafoulger creation_date: 2016-08-04T10:35:25Z [Term] id: GO:0036527 name: peptidyl-arginine deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] synonym: "deglycation of N-acetylarginine" RELATED [PMID:25416785] is_a: GO:0018195 ! peptidyl-arginine modification is_a: GO:0036525 ! protein deglycation created_by: rebeccafoulger creation_date: 2016-08-04T10:36:30Z [Term] id: GO:0036528 name: peptidyl-lysine deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] synonym: "deglycation of N-acetyllysine" RELATED [PMID:25416785] is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0036525 ! protein deglycation created_by: rebeccafoulger creation_date: 2016-08-04T10:37:12Z [Term] id: GO:0036529 name: protein deglycation, glyoxal removal namespace: biological_process def: "The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785] synonym: "protein deglycation of glyoxal-glycated protein" RELATED [PMID:25416785] is_a: GO:0036525 ! protein deglycation is_a: GO:0046295 ! glycolate biosynthetic process is_a: GO:1903189 ! glyoxal metabolic process created_by: rebeccafoulger creation_date: 2016-08-04T10:41:25Z [Term] id: GO:0036530 name: protein deglycation, methylglyoxal removal namespace: biological_process def: "The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785] synonym: "protein deglycation of methylglyoxal-glycated protein" RELATED [PMID:25416785] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0019249 ! lactate biosynthetic process is_a: GO:0036525 ! protein deglycation created_by: rebeccafoulger creation_date: 2016-08-04T10:42:26Z [Term] id: GO:0036531 name: glutathione deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine." [GOC:bf, GOC:PARL, PMID:25416785] is_a: GO:0006749 ! glutathione metabolic process created_by: rebeccafoulger creation_date: 2016-08-04T10:45:27Z [Term] id: GO:0038001 name: paracrine signaling namespace: biological_process def: "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782] comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling. synonym: "paracrine signalling" EXACT [GOC:bf] is_a: GO:0007267 ! cell-cell signaling created_by: rfoulger creation_date: 2011-02-25T02:11:00Z [Term] id: GO:0038002 name: endocrine signaling namespace: biological_process def: "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782] comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling. synonym: "endocrine signalling" EXACT [GOC:bf] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0050886 ! endocrine process created_by: rfoulger creation_date: 2011-02-25T02:12:19Z [Term] id: GO:0038003 name: opioid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands." [GOC:bf, PMID:20494127] synonym: "opioid receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2011-03-03T02:00:02Z [Term] id: GO:0038004 name: epidermal growth factor receptor ligand maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524] synonym: "EGFR ligand maturation" EXACT [GOC:bf] is_a: GO:0035638 ! signal maturation is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0051604 ! protein maturation created_by: rfoulger creation_date: 2011-06-07T03:06:41Z [Term] id: GO:0038005 name: peptide bond cleavage involved in epidermal growth factor receptor ligand maturation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment." [GOC:signaling, PMID:11672524, PMID:11672525] synonym: "EGFR ligand maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "EGFR ligand processing" EXACT [GOC:bf] synonym: "epidermal growth factor receptor ligand processing" EXACT [GOC:bf] synonym: "peptide bond cleavage involved in EGFR ligand maturation" EXACT [GOC:bf] is_a: GO:0016485 ! protein processing intersection_of: GO:0016485 ! protein processing intersection_of: part_of GO:0038004 ! epidermal growth factor receptor ligand maturation relationship: has_part GO:0006509 ! membrane protein ectodomain proteolysis relationship: part_of GO:0038004 ! epidermal growth factor receptor ligand maturation created_by: rfoulger creation_date: 2011-06-07T03:08:41Z [Term] id: GO:0038006 name: netrin receptor activity involved in chemoattraction namespace: molecular_function def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin." [GOC:signaling] synonym: "attractive netrin receptor activity" EXACT [GOC:bf] synonym: "netrin receptor activity involved in positive chemotaxis" EXACT [GOC:bf] is_a: GO:0005042 ! netrin receptor activity intersection_of: GO:0005042 ! netrin receptor activity intersection_of: part_of GO:0050918 ! positive chemotaxis relationship: part_of GO:0050918 ! positive chemotaxis created_by: rfoulger creation_date: 2011-06-10T02:22:29Z [Term] id: GO:0038007 name: netrin-activated signaling pathway namespace: biological_process def: "A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323] synonym: "netrin signaling pathway" EXACT [GOC:bf] synonym: "netrin-activated signal transduction pathway" EXACT [GOC:bf] synonym: "netrin-activated signalling pathway" EXACT [GOC:bf] synonym: "netrin-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2011-06-10T02:24:59Z [Term] id: GO:0038008 name: TRAF-mediated signal transduction namespace: biological_process def: "The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components." [GOC:bf, PMID:19918944, PMID:20596822] synonym: "TRAF signaling" EXACT [GOC:bf] synonym: "TRAF-mediated intracellular signaling" EXACT [GOC:bf] synonym: "TRAF-mediated signaling" EXACT [GOC:bf] synonym: "TRAF-mediated signalling" EXACT [GOC:bf] synonym: "tumor necrosis factor receptor-associated factor signal transduction" EXACT [GOC:bf] synonym: "tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] is_a: GO:0035556 ! intracellular signal transduction created_by: rfoulger creation_date: 2011-06-22T04:01:54Z [Term] id: GO:0038009 name: regulation of signal transduction by receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway." [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798] synonym: "regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031623 ! receptor internalization intersection_of: GO:0031623 ! receptor internalization intersection_of: regulates GO:0007165 ! signal transduction created_by: rfoulger creation_date: 2011-06-23T03:28:47Z [Term] id: GO:0038010 name: positive regulation of signal transduction by receptor internalization namespace: biological_process def: "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798] synonym: "positive regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0038009 ! regulation of signal transduction by receptor internalization intersection_of: GO:0031623 ! receptor internalization intersection_of: positively_regulates GO:0007165 ! signal transduction created_by: rfoulger creation_date: 2011-06-23T03:37:10Z [Term] id: GO:0038011 name: negative regulation of signal transduction by receptor internalization namespace: biological_process def: "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798] synonym: "negative regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0038009 ! regulation of signal transduction by receptor internalization intersection_of: GO:0031623 ! receptor internalization intersection_of: negatively_regulates GO:0007165 ! signal transduction created_by: rfoulger creation_date: 2011-06-23T03:39:06Z [Term] id: GO:0038012 name: negative regulation of Wnt signaling pathway by Wnt receptor internalization namespace: biological_process def: "Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction." [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732] synonym: "ligand-dependent internalization of Frizzled" NARROW [PMID:19643732] synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis" NARROW [GOC:bf] synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization is_a: GO:0038017 ! Wnt receptor internalization intersection_of: GO:0038017 ! Wnt receptor internalization intersection_of: negatively_regulates GO:0016055 ! Wnt signaling pathway created_by: rfoulger creation_date: 2011-06-23T03:57:59Z [Term] id: GO:0038013 name: positive regulation of Wnt signaling pathway by Wnt receptor internalization namespace: biological_process def: "Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway." [GOC:bf, GOC:signaling, PMID:17908284] synonym: "positive regulation of Wnt receptor signaling pathway by Frizzled internalization" RELATED [] synonym: "positive regulation of Wnt receptor signaling pathway by LRP6 internalization" NARROW [GOC:bf] synonym: "positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis" EXACT [GOC:bf] synonym: "positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization" RELATED [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization is_a: GO:0038017 ! Wnt receptor internalization intersection_of: GO:0038017 ! Wnt receptor internalization intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:02:21Z [Term] id: GO:0038014 name: negative regulation of insulin receptor signaling pathway by insulin receptor internalization namespace: biological_process def: "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation." [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114] synonym: "agonist-stimulated insulin receptor internalization" BROAD [PMID:18492485] synonym: "negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah] is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization is_a: GO:0038016 ! insulin receptor internalization is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway intersection_of: GO:0038016 ! insulin receptor internalization intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:08:31Z [Term] id: GO:0038015 name: positive regulation of insulin receptor signaling pathway by insulin receptor internalization namespace: biological_process def: "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane." [GOC:bf, GOC:signaling, PMID:9609114] synonym: "positive regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah] is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization is_a: GO:0038016 ! insulin receptor internalization is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway intersection_of: GO:0038016 ! insulin receptor internalization intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:20:11Z [Term] id: GO:0038016 name: insulin receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:3907718, PMID:9609114] synonym: "insulin receptor endocytosis" BROAD [GOC:bf] is_a: GO:0031623 ! receptor internalization created_by: rfoulger creation_date: 2011-06-23T04:24:52Z [Term] id: GO:0038017 name: Wnt receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:17908284] synonym: "Wnt receptor endocytosis" BROAD [GOC:bf] is_a: GO:0031623 ! receptor internalization created_by: rfoulger creation_date: 2011-06-23T04:25:47Z [Term] id: GO:0038018 name: Wnt receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732] synonym: "Frizzled degradation" NARROW [PMID:19643732] synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation" EXACT [GOC:bf] synonym: "Wnt receptor breakdown" EXACT [GOC:bf] synonym: "Wnt receptor catabolism" EXACT [GOC:bf] synonym: "Wnt receptor degradation" RELATED [GOC:bf] is_a: GO:0032801 ! receptor catabolic process relationship: part_of GO:0030178 ! negative regulation of Wnt signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:38:12Z [Term] id: GO:0038019 name: Wnt receptor recycling namespace: biological_process def: "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:19643732] synonym: "Frizzled recycling" NARROW [PMID:19643732] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0030177 ! positive regulation of Wnt signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:46:11Z [Term] id: GO:0038020 name: insulin receptor recycling namespace: biological_process def: "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:3907718] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0046628 ! positive regulation of insulin receptor signaling pathway created_by: rfoulger creation_date: 2011-06-23T04:52:05Z [Term] id: GO:0038021 name: leptin receptor activity namespace: molecular_function def: "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0033210 ! leptin-mediated signaling pathway created_by: rfoulger creation_date: 2011-06-27T01:36:45Z [Term] id: GO:0038022 name: G protein-coupled olfactory receptor activity namespace: molecular_function def: "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:sart, PMID:21041441] synonym: "G-protein coupled odorant receptor activity" EXACT [GOC:bf, PMID:21041441] synonym: "G-protein coupled olfactory receptor activity" EXACT [] synonym: "odorant receptor activity, G-protein coupled" NARROW [GOC:bf, PMID:21041441] synonym: "olfactory receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0004984 ! olfactory receptor activity created_by: rfoulger creation_date: 2011-07-01T11:23:51Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function alt_id: GO:0004872 alt_id: GO:0019041 def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] is_a: GO:0060089 ! molecular transducer activity created_by: rfoulger creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0038024 name: cargo receptor activity namespace: molecular_function def: "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles." [PMID:15239958, PMID:27903609] comment: Notes: (1) this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857. synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, PMID:12671190] synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf] synonym: "transport receptor activity" BROAD [GOC:signaling] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0060090 ! molecular adaptor activity relationship: part_of GO:0006897 ! endocytosis created_by: rfoulger creation_date: 2011-08-01T02:50:45Z [Term] id: GO:0038025 name: reelin receptor activity namespace: molecular_function def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879] synonym: "reeler receptor activity" EXACT [PR:000013879] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0038026 ! reelin-mediated signaling pathway created_by: rfoulger creation_date: 2011-08-02T12:01:25Z [Term] id: GO:0038026 name: reelin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879] synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879] synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf] synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2011-08-02T02:06:18Z [Term] id: GO:0038027 name: apolipoprotein A-I-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:16443932] synonym: "apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2011-08-02T02:13:41Z [Term] id: GO:0038028 name: insulin receptor signaling pathway via phosphatidylinositol 3-kinase namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade." [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212] synonym: "insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "insulin receptor signaling pathway via PI3K cascade" EXACT [GOC:bf] synonym: "insulin receptor signaling via PI3K" EXACT [GOC:bf] synonym: "insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade" EXACT [GOC:mah] is_a: GO:0008286 ! insulin receptor signaling pathway relationship: has_part GO:0014065 ! phosphatidylinositol 3-kinase signaling created_by: rfoulger creation_date: 2011-09-08T10:35:14Z [Term] id: GO:0038029 name: epidermal growth factor receptor signaling pathway via MAPK cascade namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade." [GOC:bf, GOC:signaling, PMID:21167805] synonym: "EGFR signaling pathway via MAPKKK cascade" EXACT [GOC:bf] synonym: "EGFR signaling via MAPKKK cascade" EXACT [GOC:bf] synonym: "EGFR/MAPK signaling" EXACT [GOC:bf] synonym: "epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] synonym: "epidermal growth factor receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: has_part GO:0000165 ! MAPK cascade created_by: rfoulger creation_date: 2011-09-08T10:53:01Z [Term] id: GO:0038030 name: non-canonical Wnt signaling pathway via MAPK cascade namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade." [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811] synonym: "non-canonical Wnt receptor signaling pathway via MAPK cascade" EXACT [] synonym: "non-canonical Wnt receptor signaling pathway via MAPK signaling" EXACT [GOC:bf] synonym: "non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] synonym: "non-canonical Wnt receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf] synonym: "non-canonical Wnt-activated signaling pathway via MAPK cascade" EXACT [GOC:signaling] is_a: GO:0035567 ! non-canonical Wnt signaling pathway relationship: has_part GO:0000165 ! MAPK cascade created_by: rfoulger creation_date: 2011-09-08T01:46:07Z [Term] id: GO:0038031 name: non-canonical Wnt signaling pathway via JNK cascade namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade." [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469] synonym: "non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] synonym: "non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:bf] synonym: "non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] is_a: GO:0038030 ! non-canonical Wnt signaling pathway via MAPK cascade relationship: has_part GO:0007254 ! JNK cascade created_by: rfoulger creation_date: 2011-09-08T01:57:10Z [Term] id: GO:0038032 name: termination of G protein-coupled receptor signaling pathway namespace: biological_process def: "The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] synonym: "termination of G-protein coupled receptor signaling pathway" EXACT [] synonym: "termination of G-protein coupled receptor signalling pathway" EXACT [GOC:mah] synonym: "termination of GPCR signaling pathway" EXACT [GOC:bf] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2011-09-16T10:31:21Z [Term] id: GO:0038033 name: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381] synonym: "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway" EXACT [GOC:bf] synonym: "vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis" RELATED [GOC:bf] synonym: "VEGF-mediated chemotactic endothelial cell migration" BROAD [GOC:bf, PMID:21245381] synonym: "VEGF-VEGFR-induced endothelial cell chemotaxis" EXACT [GOC:bf] is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis created_by: rfoulger creation_date: 2011-09-19T02:36:37Z [Term] id: GO:0038034 name: signal transduction in absence of ligand namespace: biological_process def: "A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] synonym: "addiction receptor signaling pathway" BROAD [PMID:15044679] synonym: "basal signaling" NARROW [GOC:al] synonym: "dependence receptor signaling pathway" BROAD [PMID:15044679] synonym: "negative signal transduction" RELATED [PMID:15044679] synonym: "non-classical signal transduction" BROAD [PMID:15044679] synonym: "signal transduction in absence of agonist" EXACT [GOC:bf] is_a: GO:0007165 ! signal transduction created_by: rfoulger creation_date: 2011-10-26T02:21:03Z [Term] id: GO:0038035 name: G protein-coupled receptor signaling in absence of ligand namespace: biological_process def: "A series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist." [GOC:al, PMID:12402500, PMID:17629961] comment: This term is intended for use by G protein-coupled receptors which signal at a low-level in the absence of agonist binding. synonym: "basal G-protein coupled receptor signaling" NARROW [GOC:al] synonym: "G-protein coupled receptor signaling in absence of agonist" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling in absence of ligand" EXACT [] synonym: "G-protein coupled receptor signalling in absence of ligand" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0038034 ! signal transduction in absence of ligand created_by: rfoulger creation_date: 2011-10-26T02:31:37Z [Term] id: GO:0038036 name: sphingosine-1-phosphate receptor activity namespace: molecular_function def: "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, PMID:12728273, Wikipedia:S1PR1] synonym: "S1P receptor activity" EXACT [Wikipedia:Sphingosine_1-phosphate] is_a: GO:0045125 ! bioactive lipid receptor activity relationship: part_of GO:0003376 ! sphingosine-1-phosphate receptor signaling pathway created_by: rfoulger creation_date: 2011-10-28T03:46:54Z [Term] id: GO:0038037 name: G protein-coupled receptor dimeric complex namespace: cellular_component def: "A protein complex that contains two G protein-coupled receptors." [GOC:al, GOC:bf, PMID:10713101] synonym: "G-protein coupled receptor dimer" EXACT [GOC:bf] synonym: "G-protein coupled receptor dimeric complex" EXACT [] synonym: "GPCR dimer" EXACT [GOC:bf] is_a: GO:0097648 ! G protein-coupled receptor complex created_by: rfoulger creation_date: 2011-11-02T04:42:44Z [Term] id: GO:0038038 name: G protein-coupled receptor homodimeric complex namespace: cellular_component def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor." [GOC:al, GOC:bf, PMID:10713101, PMID:16670762] synonym: "G-protein coupled receptor homodimer" EXACT [GOC:bf] synonym: "G-protein coupled receptor homodimeric complex" EXACT [] synonym: "GPCR homodimer" EXACT [GOC:bf] is_a: GO:0038037 ! G protein-coupled receptor dimeric complex created_by: rfoulger creation_date: 2011-11-02T04:43:53Z [Term] id: GO:0038039 name: G protein-coupled receptor heterodimeric complex namespace: cellular_component def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590] synonym: "G-protein coupled receptor heterodimer" EXACT [GOC:bf] synonym: "G-protein coupled receptor heterodimeric complex" EXACT [] synonym: "GPCR heterodimer" EXACT [PMID:20150590] is_a: GO:0038037 ! G protein-coupled receptor dimeric complex created_by: rfoulger creation_date: 2011-11-02T04:44:20Z [Term] id: GO:0038040 name: obsolete cross-receptor activation within G-protein coupled receptor heterodimer namespace: biological_process def: "OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter." [GOC:al, GOC:bf, PMID:21063387] comment: This term was obsoleted because it should be captured as a GO-CAM model, see https://github.com/geneontology/go-ontology/issues/15823. is_obsolete: true created_by: rfoulger creation_date: 2011-11-02T04:50:22Z [Term] id: GO:0038041 name: cross-receptor inhibition within G protein-coupled receptor heterodimer namespace: biological_process def: "Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit." [GOC:al, GOC:bf, PMID:15979374] synonym: "cross-receptor inhibition within G-protein coupled receptor heterodimer" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:2000272 ! negative regulation of signaling receptor activity created_by: rfoulger creation_date: 2011-11-02T04:52:24Z [Term] id: GO:0038043 name: interleukin-5-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:pg, GOC:signaling, PR:000001392] synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2011-11-03T04:18:21Z [Term] id: GO:0038044 name: transforming growth factor-beta secretion namespace: biological_process def: "The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs)." [GOC:bf, GOC:yaf, PMID:2350783, Reactome:R-HSA-177107] synonym: "TGF-beta secretion" EXACT [PMID:2022183] synonym: "TGFbeta secretion" EXACT [PMID:16891311] is_a: GO:0050663 ! cytokine secretion created_by: rfoulger creation_date: 2011-11-03T04:23:35Z [Term] id: GO:0038045 name: large latent transforming growth factor-beta complex namespace: cellular_component def: "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors." [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445, Reactome:R-HSA-177107] synonym: "large latent complex" EXACT [Reactome:R-HSA-177107] synonym: "LLC" EXACT [Reactome:R-HSA-177107] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2011-11-03T04:29:49Z [Term] id: GO:0038046 name: enkephalin receptor activity namespace: molecular_function def: "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body." [GOC:bf, Wikipedia:Enkephalin] synonym: "delta-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity created_by: rfoulger creation_date: 2011-11-14T01:30:14Z [Term] id: GO:0038047 name: morphine receptor activity namespace: molecular_function def: "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf] synonym: "mu-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity relationship: part_of GO:0071315 ! cellular response to morphine created_by: rfoulger creation_date: 2011-11-14T01:35:18Z [Term] id: GO:0038048 name: dynorphin receptor activity namespace: molecular_function def: "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin." [GOC:bf, Wikipedia:Dynorphin] synonym: "kappa-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity created_by: rfoulger creation_date: 2011-11-14T01:48:02Z [Term] id: GO:0038053 name: obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements." [GOC:signaling, PMID:17615392] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "estrogen nuclear receptor activity" BROAD [GOC:bf] synonym: "estrogen-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT [] is_obsolete: true created_by: rfoulger creation_date: 2011-11-29T02:42:22Z [Term] id: GO:0038054 name: G protein-coupled estrogen receptor activity namespace: molecular_function def: "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:signaling, PMID:17379646, PMID:20960099] synonym: "G-protein coupled estrogen receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0030284 ! estrogen receptor activity created_by: rfoulger creation_date: 2011-11-29T04:29:42Z [Term] id: GO:0038055 name: BMP secretion namespace: biological_process def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart, PR:000000034] synonym: "BMP protein secretion" EXACT [GOC:bf] synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf] is_a: GO:0009306 ! protein secretion is_a: GO:0023061 ! signal release created_by: rfoulger creation_date: 2011-12-14T02:31:39Z [Term] id: GO:0038056 name: negative regulation of BMP signaling pathway by negative regulation of BMP secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell." [GOC:bf, GOC:sart, PMID:21750037] synonym: "negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion" EXACT [GOC:bf] synonym: "negative regulation of BMP signalling pathway by negative regulation of BMP secretion" EXACT [GOC:bf] is_a: GO:0030514 ! negative regulation of BMP signaling pathway is_a: GO:2001285 ! negative regulation of BMP secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030509 ! BMP signaling pathway intersection_of: negatively_regulates GO:0038055 ! BMP secretion created_by: rfoulger creation_date: 2011-12-19T10:55:47Z [Term] id: GO:0038057 name: TNFSF11 binding namespace: molecular_function def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm, PR:000002107] synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107] synonym: "ODF binding" EXACT [GOC:sl, PR:000002107] synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107] synonym: "osteoclast differentiation factor binding" EXACT [GOC:sl, PR:000002107] synonym: "osteoprotegerin ligand binding" EXACT [GOC:sl, PR:000002107] synonym: "RANKL binding" EXACT [GOC:sl, PR:000002107] synonym: "receptor activator of nuclear factor kappa-B ligand binding" EXACT [GOC:sl, PR:000002107] synonym: "TNF-related activation-induced cytokine binding" EXACT [GOC:sl, PR:000002107] synonym: "TRANCE binding" EXACT [GOC:sl, PR:000002107] synonym: "tumor necrosis factor (ligand) superfamily member 11 binding" EXACT [GOC:bf] synonym: "tumor necrosis factor ligand superfamily member 11 binding" EXACT [PR:000002107] synonym: "tumor necrosis factor superfamily member 11 binding" EXACT [GOC:bf] is_a: GO:0043120 ! tumor necrosis factor binding created_by: rfoulger creation_date: 2012-01-04T03:25:59Z [Term] id: GO:0038058 name: TNFSF11 receptor activity namespace: molecular_function def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm, PR:000002107] synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] is_a: GO:0005031 ! tumor necrosis factor-activated receptor activity relationship: has_part GO:0038057 ! TNFSF11 binding relationship: part_of GO:0071847 ! TNFSF11-mediated signaling pathway created_by: rfoulger creation_date: 2012-01-04T03:31:54Z [Term] id: GO:0038059 name: IKKalpha-IKKalpha complex namespace: cellular_component def: "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits." [GOC:bf, PMID:18626576, PMID:21173796] synonym: "IkappaB kinase alpha homodimer" EXACT [GOC:bf] synonym: "IkappaB kinase-alpha homodimer" EXACT [PMID:21173796] synonym: "IKKalpha homodimer" EXACT [GOC:bf] synonym: "IKKalpha homodimeric complex" EXACT [GOC:bf] synonym: "IKKalpha-IKKalpha protein complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2012-01-10T09:29:53Z [Term] id: GO:0038060 name: nitric oxide-cGMP-mediated signaling pathway namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632] synonym: "canonical nitric oxide signaling" EXACT [GOC:bf] synonym: "classical nitric oxide signaling" EXACT [PMID:21549190] synonym: "nitric oxide-cGMP-mediated signalling pathway" EXACT [GOC:mah] synonym: "NO-cGMP signaling pathway" EXACT [PMID:22019632] is_a: GO:0007263 ! nitric oxide mediated signal transduction is_a: GO:0019934 ! cGMP-mediated signaling created_by: rfoulger creation_date: 2012-01-10T05:32:39Z [Term] id: GO:0038061 name: NIK/NF-kappaB signaling namespace: biological_process def: "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882] synonym: "NIK/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "NIK/NF-kappaB signal transduction" EXACT [GOC:signaling] synonym: "non-canonical NF-KB signaling" BROAD [PMID:21173796] synonym: "noncanonical NF-kappaB signaling" BROAD [PMID:20501935] synonym: "noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [PMID:20501935] synonym: "p52-dependent NF-kappaB signaling" NARROW [PMID:18292232] is_a: GO:0035556 ! intracellular signal transduction relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity created_by: rfoulger creation_date: 2012-01-16T05:44:46Z [Term] id: GO:0038062 name: protein tyrosine kinase collagen receptor activity namespace: molecular_function def: "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710] synonym: "collagen RTK activity" EXACT [PMID:21568710] synonym: "discoidin domain receptor" RELATED [PMID:16626936] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0038064 ! collagen receptor activity relationship: part_of GO:0038063 ! collagen-activated tyrosine kinase receptor signaling pathway created_by: rfoulger creation_date: 2012-01-18T01:38:40Z [Term] id: GO:0038063 name: collagen-activated tyrosine kinase receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936] synonym: "collagen-activated RTK signaling pathway" EXACT [PMID:21568710] synonym: "collagen-activated tyrosine kinase receptor signalling pathway" EXACT [GOC:mah] synonym: "DDR signaling pathway" NARROW [PMID:16626936] synonym: "discoidin domain receptor signaling pathway" NARROW [PMID:16626936] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0038065 ! collagen-activated signaling pathway created_by: rfoulger creation_date: 2012-01-18T01:43:20Z [Term] id: GO:0038064 name: collagen receptor activity namespace: molecular_function def: "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:uh, PMID:21568710] synonym: "transmembrane collagen receptor activity" EXACT [PMID:21568710] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0005518 ! collagen binding relationship: part_of GO:0038065 ! collagen-activated signaling pathway created_by: rfoulger creation_date: 2012-01-18T01:52:42Z [Term] id: GO:0038065 name: collagen-activated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:21568710] synonym: "collagen-activated signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2012-01-18T01:57:37Z [Term] id: GO:0038066 name: p38MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:signaling, PMID:20811974] synonym: "p38 cascade" EXACT [PMID:20811974] synonym: "p38 MAPK cascade" EXACT [GOC:bf] is_a: GO:0051403 ! stress-activated MAPK cascade created_by: rfoulger creation_date: 2012-01-25T11:51:24Z [Term] id: GO:0038067 name: obsolete MAP kinase activity involved in cell wall organization or biogenesis namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase activity involved in cell wall biogenesis" NARROW [] synonym: "MAP kinase activity involved in cell wall integrity" RELATED [GOC:vw] synonym: "MAPK activity involved in cell wall biogenesis" NARROW [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-25T03:29:04Z [Term] id: GO:0038068 name: obsolete MAP kinase kinase activity involved in cell wall organization or biogenesis namespace: molecular_function def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase kinase activity involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAP2K activity involved in cell wall integrity" EXACT [GOC:bf] synonym: "MAPKK activity involved in cell wall integrity" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-25T03:34:10Z [Term] id: GO:0038069 name: obsolete MAP kinase phosphatase activity involved in regulation of cell wall biogenesis namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "Mpk1 phosphatase activity" NARROW [PMID:10523653] synonym: "Slt2 phosphatase activity" NARROW [PMID:10523653] is_obsolete: true created_by: rfoulger creation_date: 2012-01-25T03:38:58Z [Term] id: GO:0038070 name: obsolete MAP kinase kinase kinase activity involved in cell wall organization or biogenesis namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase kinase kinase activity involved in cell wall biogenesis" EXACT [GOC:vw] synonym: "MAP3K activity involved in cell wall integrity" EXACT [GOC:bf] synonym: "MAPKKK activity involved in cell wall integrity" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-25T03:43:46Z [Term] id: GO:0038071 name: obsolete MAP kinase activity involved in conjugation with cellular fusion namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAPK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:31:57Z [Term] id: GO:0038072 name: obsolete MAP kinase kinase activity involved in conjugation with cellular fusion namespace: molecular_function def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP2K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] synonym: "MAPKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:31:57Z [Term] id: GO:0038073 name: obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP3K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] synonym: "MAPKKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:31:57Z [Term] id: GO:0038074 name: obsolete MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAPK phosphatase activity involved in regulation of conjugation with cellular fusion" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:31:57Z [Term] id: GO:0038075 name: obsolete MAP kinase activity involved in innate immune response namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] comment: This term was obsoleted because it should be represented as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/18000. synonym: "MAPK activity involved in innate immune response" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:35:52Z [Term] id: GO:0038076 name: obsolete MAP kinase kinase activity involved in innate immune response namespace: molecular_function def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP2K activity involved in innate immune response" EXACT [GOC:signaling] synonym: "MAPKK activity involved in innate immune response" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:35:52Z [Term] id: GO:0038077 name: obsolete MAP kinase kinase kinase activity involved in innate immune response namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP3K activity involved in innate immune response" EXACT [GOC:signaling] synonym: "MAPKKK activity involved in innate immune response" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:35:52Z [Term] id: GO:0038078 name: MAP kinase phosphatase activity involved in regulation of innate immune response namespace: molecular_function def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] synonym: "MAPK phosphatase activity involved in regulation of innate immune response" EXACT [GOC:bf] is_a: GO:0033549 ! MAP kinase phosphatase activity intersection_of: GO:0033549 ! MAP kinase phosphatase activity intersection_of: part_of GO:0045088 ! regulation of innate immune response relationship: part_of GO:0035423 ! inactivation of MAPK activity involved in innate immune response relationship: part_of GO:0045088 ! regulation of innate immune response created_by: rfoulger creation_date: 2012-01-26T02:35:52Z [Term] id: GO:0038079 name: obsolete MAP kinase activity involved in osmosensory signaling pathway namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "MAPK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:41:31Z [Term] id: GO:0038080 name: obsolete MAP kinase kinase activity involved in osmosensory signaling pathway namespace: molecular_function def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "MAP2K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] synonym: "MAPKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:41:31Z [Term] id: GO:0038081 name: obsolete MAP kinase kinase kinase activity involved in osmosensory signaling pathway namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "MAP kinase kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "MAP3K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] synonym: "MAPKKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:41:31Z [Term] id: GO:0038082 name: obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. synonym: "Hog1 phosphatase activity" NARROW [PMID:20880736] synonym: "MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway" EXACT [GOC:mah] synonym: "MAPK phosphatase activity involved in regulation of osmosensory signaling pathway" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-26T02:41:31Z [Term] id: GO:0038083 name: peptidyl-tyrosine autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein." [PMID:10037737, PMID:10068444, PMID:10940390] synonym: "receptor tyrosine kinase autophosphorylation" NARROW [PMID:20432069] synonym: "RTK autophosphorylation" NARROW [PMID:20432069] synonym: "tyrosine autophosphorylation" EXACT [PMID:16431914] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0046777 ! protein autophosphorylation created_by: rfoulger creation_date: 2012-02-01T02:14:18Z [Term] id: GO:0038084 name: vascular endothelial growth factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285] comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'. synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf] synonym: "VEGF signaling" EXACT [GOC:bf] synonym: "VEGF-activated signaling pathway" EXACT [GOC:bf] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus created_by: rfoulger creation_date: 2012-02-01T02:27:32Z [Term] id: GO:0038085 name: vascular endothelial growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285] synonym: "VEGF binding" EXACT [GOC:bf] is_a: GO:0019838 ! growth factor binding created_by: rfoulger creation_date: 2012-02-01T02:36:36Z [Term] id: GO:0038086 name: VEGF-activated platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A/PDGFR signaling" NARROW [PMID:17470632] synonym: "VEGF-activated PDGFR signalling pathway" EXACT [GOC:bf] synonym: "VEGF-activated platelet-derived growth factor receptor signalling pathway" EXACT [GOC:bf] synonym: "VEGF/PDGFR signaling pathway" EXACT [PMID:17470632] is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway relationship: has_part GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2012-02-01T03:05:43Z [Term] id: GO:0038087 name: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A/PDGFRalpha signaling" NARROW [PMID:17470632] synonym: "VEGF-activated PDGFRalpha signalling pathway" EXACT [GOC:bf] synonym: "VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:bf] synonym: "VEGF/PDGFRalpha signaling pathway" EXACT [PMID:17470632] is_a: GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway created_by: rfoulger creation_date: 2012-02-01T03:08:13Z [Term] id: GO:0038088 name: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A/PDGFRbeta signaling" NARROW [PMID:17470632] synonym: "VEGF-activated PDGFRbeta signalling pathway" EXACT [GOC:bf] synonym: "VEGF-activated platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:bf] synonym: "VEGF/PDGFRbeta signaling pathway" EXACT [PMID:17470632] is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway created_by: rfoulger creation_date: 2012-02-01T03:10:16Z [Term] id: GO:0038089 name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PR:000003096, PR:000017284, PR:000017285] synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632] synonym: "VEGF-induced cell migration" EXACT [GOC:bf] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway intersection_of: GO:0038084 ! vascular endothelial growth factor signaling pathway intersection_of: positively_regulates GO:0016477 ! cell migration created_by: rfoulger creation_date: 2012-02-02T03:40:13Z [Term] id: GO:0038090 name: positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PMID:17470632] synonym: "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of cell migration by VEGF/PDGFR signaling pathway" EXACT [PMID:17470632] synonym: "VEGF/PDGFR-induced cell migration" EXACT [PMID:17470632] is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway intersection_of: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway intersection_of: positively_regulates GO:0016477 ! cell migration created_by: rfoulger creation_date: 2012-02-02T03:41:23Z [Term] id: GO:0038091 name: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation." [GOC:signaling, PMID:17470632] synonym: "positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of cell proliferation by VEGF/PDGFR signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A-induced cell proliferation" NARROW [PMID:17470632] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway intersection_of: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway intersection_of: positively_regulates GO:0008283 ! cell population proliferation created_by: rfoulger creation_date: 2012-02-02T03:45:49Z [Term] id: GO:0038092 name: nodal signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255] synonym: "nodal signaling" EXACT [GOC:bf] synonym: "nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032924 ! activin receptor signaling pathway created_by: rfoulger creation_date: 2012-02-16T02:44:02Z [Term] id: GO:0038093 name: Fc receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor] synonym: "Fc receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway created_by: rfoulger creation_date: 2012-02-16T05:11:30Z [Term] id: GO:0038094 name: Fc-gamma receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038] synonym: "Fc-gamma receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0038093 ! Fc receptor signaling pathway created_by: rfoulger creation_date: 2012-02-16T05:22:46Z [Term] id: GO:0038095 name: Fc-epsilon receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725] synonym: "Fc-epsilon receptor signalling pathway" EXACT [GOC:bf] is_a: GO:0038093 ! Fc receptor signaling pathway created_by: rfoulger creation_date: 2012-02-16T05:23:51Z [Term] id: GO:0038096 name: Fc-gamma receptor signaling pathway involved in phagocytosis namespace: biological_process def: "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916] synonym: "Fc gamma receptor-dependent phagocytosis" EXACT [PMID:18832707] synonym: "Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:bf] synonym: "Fcgamma receptor-mediated phagocytosis" EXACT [PMID:15466916] synonym: "IgG-mediated phagocytosis" EXACT [PMID:1248849] is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway is_a: GO:0002433 ! immune response-regulating cell surface receptor signaling pathway involved in phagocytosis is_a: GO:0038094 ! Fc-gamma receptor signaling pathway intersection_of: GO:0038094 ! Fc-gamma receptor signaling pathway intersection_of: part_of GO:0006909 ! phagocytosis created_by: rfoulger creation_date: 2012-02-16T05:26:25Z [Term] id: GO:0038097 name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway namespace: biological_process def: "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:phg, PMID:12413516] synonym: "Fc epsilon RI-dependent mast cell activation" EXACT [PMID:18377769] synonym: "Fc epsilon RI-mediated mast cell activation" EXACT [PMID:17336609] synonym: "positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway is_a: GO:0033005 ! positive regulation of mast cell activation is_a: GO:0038095 ! Fc-epsilon receptor signaling pathway intersection_of: GO:0038095 ! Fc-epsilon receptor signaling pathway intersection_of: positively_regulates GO:0045576 ! mast cell activation created_by: rfoulger creation_date: 2012-02-16T05:30:09Z [Term] id: GO:0038098 name: sequestering of BMP from receptor via BMP binding namespace: biological_process def: "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014] synonym: "extracellular sequestering of BMP" BROAD [GOC:bf] synonym: "extracellular sequestering of bone morphogenetic protein" BROAD [GOC:bf] is_a: GO:0030514 ! negative regulation of BMP signaling pathway is_a: GO:0035581 ! sequestering of extracellular ligand from receptor created_by: rfoulger creation_date: 2012-02-22T11:28:54Z [Term] id: GO:0038099 name: nodal receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals)." [GOC:bf, GOC:signaling, PMID:15062104] synonym: "ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:bf] synonym: "nodal receptor complex formation" EXACT [GOC:bf] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0038092 ! nodal signaling pathway created_by: rfoulger creation_date: 2012-02-17T11:16:40Z [Term] id: GO:0038100 name: nodal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020, PR:000000105] is_a: GO:0005515 ! protein binding created_by: rfoulger creation_date: 2012-02-17T11:19:08Z [Term] id: GO:0038101 name: sequestering of nodal from receptor via nodal binding namespace: biological_process def: "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor." [GOC:signaling, PMID:14570583, PMID:15062104] synonym: "binding to and sequestering nodal" EXACT [GOC:bf] synonym: "extracellular regulation of nodal" BROAD [GOC:bf] synonym: "nodal antagonist activity" BROAD [PMID:14570583] is_a: GO:0035581 ! sequestering of extracellular ligand from receptor relationship: has_part GO:0038100 ! nodal binding relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway created_by: rfoulger creation_date: 2012-02-17T11:21:22Z [Term] id: GO:0038102 name: activin receptor antagonist activity namespace: molecular_function def: "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104] comment: This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal. is_a: GO:0048019 ! receptor antagonist activity relationship: part_of GO:0032926 ! negative regulation of activin receptor signaling pathway created_by: rfoulger creation_date: 2012-02-17T11:28:59Z [Term] id: GO:0038103 name: activin receptor antagonist activity involved in negative regulation of nodal signaling pathway namespace: molecular_function def: "Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104] synonym: "activin receptor antagonist activity involved in negative regulation of nodal signalling pathway" EXACT [GOC:mah] synonym: "nodal antagonist activity" EXACT [GOC:bf] is_a: GO:0038102 ! activin receptor antagonist activity intersection_of: GO:0038102 ! activin receptor antagonist activity intersection_of: part_of GO:1900108 ! negative regulation of nodal signaling pathway relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway created_by: rfoulger creation_date: 2012-02-17T11:30:21Z [Term] id: GO:0038104 name: nodal receptor complex namespace: cellular_component def: "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell." [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104] comment: Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex. synonym: "ActRIIB.ALK4.EGF-CFC complex" NARROW [GOC:bf] is_a: GO:0043235 ! receptor complex created_by: rfoulger creation_date: 2012-02-17T11:12:21Z [Term] id: GO:0038105 name: sequestering of TGFbeta from receptor via TGFbeta binding namespace: biological_process def: "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014] comment: This term is for annotation of gene products that bind to TGFbeta. For gene products that tether the TGFbeta-containing latency complex to the extracellular matrix, but do not necessarily bind TGF-beta directly, consider instead annotating to 'sequestering of TGFbeta in extracellular matrix ; GO:0035583'. synonym: "extracellular sequestering of TGFbeta" BROAD [GOC:bf] synonym: "extracellular sequestering of transforming growth factor-beta" BROAD [GOC:bf] is_a: GO:0035581 ! sequestering of extracellular ligand from receptor created_by: rfoulger creation_date: 2012-02-22T11:35:58Z [Term] id: GO:0038106 name: choriogonadotropin hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit." [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin] synonym: "chorionic gonadotrophin binding" EXACT [Wikilpedia:Human_chorionic_gonadotropin] synonym: "chorionic gonadotropin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin] is_a: GO:0042562 ! hormone binding created_by: rfoulger creation_date: 2012-03-08T03:58:40Z [Term] id: GO:0038107 name: nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706] synonym: "nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry" EXACT [GOC:bf] is_a: GO:0038092 ! nodal signaling pathway is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry intersection_of: GO:0038092 ! nodal signaling pathway intersection_of: part_of GO:0007368 ! determination of left/right symmetry created_by: rfoulger creation_date: 2012-02-29T10:18:59Z [Term] id: GO:0038108 name: negative regulation of appetite by leptin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food." [GOC:BHF, GOC:vk, PMID:19150989] synonym: "inhibition of appetite by leptin signaling" EXACT [GOC:bf] synonym: "negative regulation of appetite by leptin-mediated signalling pathway" EXACT [GOC:mah] synonym: "reduction of appetite by leptin-mediated signaling" EXACT [GOC:bf] synonym: "suppression of appetite by leptin-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0032099 ! negative regulation of appetite is_a: GO:0033210 ! leptin-mediated signaling pathway created_by: rfoulger creation_date: 2012-03-09T11:14:36Z [Term] id: GO:0038109 name: Kit signaling pathway namespace: biological_process def: "A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell." [GOC:nhn, GOC:signaling, PMID:16129412] synonym: "Kit signalling pathway" EXACT [GOC:mah] synonym: "SCF signaling pathway" EXACT [PMID:18787413] synonym: "stem cell factor receptor signaling pathway" EXACT [PMID:16129412] synonym: "stem cell factor signaling pathway" EXACT [PMID:16129412] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0036216 ! cellular response to stem cell factor stimulus created_by: rfoulger creation_date: 2012-03-22T10:09:48Z [Term] id: GO:0038110 name: interleukin-2-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-2-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-2-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071352 ! cellular response to interleukin-2 created_by: rfoulger creation_date: 2012-03-22T10:18:29Z [Term] id: GO:0038111 name: interleukin-7-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-7-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-7-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0098761 ! cellular response to interleukin-7 created_by: rfoulger creation_date: 2012-03-22T10:19:27Z [Term] id: GO:0038112 name: interleukin-8-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-8-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-8-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0098759 ! cellular response to interleukin-8 created_by: rfoulger creation_date: 2012-03-22T10:19:59Z [Term] id: GO:0038113 name: interleukin-9-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-9-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-9-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071355 ! cellular response to interleukin-9 created_by: rfoulger creation_date: 2012-03-22T10:20:33Z [Term] id: GO:0038114 name: interleukin-21-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-21-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-21-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0098757 ! cellular response to interleukin-21 created_by: rfoulger creation_date: 2012-03-22T10:21:01Z [Term] id: GO:0038115 name: chemokine (C-C motif) ligand 19 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001991] comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'. synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203] synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845] synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:28:32Z [Term] id: GO:0038116 name: chemokine (C-C motif) ligand 21 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001993] comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203] synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845] synonym: "chemokine (C-C motif) ligand 21 signalling pathway" EXACT [GOC:mah] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:30:47Z [Term] id: GO:0038117 name: C-C motif chemokine 19 receptor activity namespace: molecular_function def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001991] synonym: "CCL19 receptor activity" RELATED [PMID:15059845] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: has_part GO:0035757 ! chemokine (C-C motif) ligand 19 binding relationship: part_of GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:59:10Z [Term] id: GO:0038118 name: C-C chemokine receptor CCR7 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365, PR:000001203] comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah] synonym: "CCR7 signaling pathway" RELATED [PR:000001203] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:43:57Z [Term] id: GO:0038119 name: CCL19-activated CCR7 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203] synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah] is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:47:24Z [Term] id: GO:0038120 name: CCL21-activated CCR7 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203] synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah] is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway created_by: rfoulger creation_date: 2012-03-22T11:47:24Z [Term] id: GO:0038121 name: C-C motif chemokine 21 receptor activity namespace: molecular_function def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001993] synonym: "CCL21 receptor activity" RELATED [PMID:15059845, PR:000001993] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: has_part GO:0035758 ! chemokine (C-C motif) ligand 21 binding relationship: part_of GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway created_by: rfoulger creation_date: 2012-03-22T01:28:06Z [Term] id: GO:0038122 name: C-C motif chemokine 5 receptor activity namespace: molecular_function def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PR:000002094] synonym: "CCL5 receptor activity" EXACT [PR:000002094] synonym: "RANTES receptor activity" EXACT [GOC:bf] synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: has_part GO:0071791 ! chemokine (C-C motif) ligand 5 binding relationship: part_of GO:0035689 ! chemokine (C-C motif) ligand 5 signaling pathway created_by: rfoulger creation_date: 2012-03-22T01:36:00Z [Term] id: GO:0038123 name: toll-like receptor TLR1:TLR2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230] synonym: "TLR2:TLR1 signaling pathway" EXACT [GOC:bf] synonym: "toll-like receptor TLR1:TLR2 signalling pathway" EXACT [GOC:mah] is_a: GO:0002224 ! toll-like receptor signaling pathway created_by: rfoulger creation_date: 2012-03-23T10:20:13Z [Term] id: GO:0038124 name: toll-like receptor TLR6:TLR2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230] synonym: "TLR2:TLR6 signaling pathway" EXACT [GOC:bf] synonym: "toll-like receptor TLR6:TLR2 signalling pathway" EXACT [GOC:mah] is_a: GO:0002224 ! toll-like receptor signaling pathway created_by: rfoulger creation_date: 2012-03-23T10:29:09Z [Term] id: GO:0038127 name: ERBB signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000001812, Wikipedia:ErbB] synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398] synonym: "EGFR family signaling pathway" RELATED [PMID:11597398] synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB] synonym: "ERBB signalling pathway" EXACT [GOC:mah] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway created_by: rfoulger creation_date: 2012-03-30T09:23:01Z [Term] id: GO:0038128 name: ERBB2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, PR:000002082, Reactome:R-HSA-1227986] synonym: "ERBB2 signalling pathway" EXACT [GOC:mah] synonym: "HER2 signaling pathway" EXACT [PR:000002082] synonym: "NEU signaling" EXACT [Reactome:R-HSA-1227986] synonym: "receptor tyrosine-protein kinase erbB-2 signaling pathway" EXACT [PR:000002082] is_a: GO:0038127 ! ERBB signaling pathway created_by: rfoulger creation_date: 2012-03-30T10:05:12Z [Term] id: GO:0038129 name: ERBB3 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, PR:000007159, Reactome:R-HSA-1247497] synonym: "ERBB3 signalling pathway" EXACT [GOC:mah] synonym: "HER3 signaling pathway" EXACT [PR:000007159] synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159] is_a: GO:0038127 ! ERBB signaling pathway created_by: rfoulger creation_date: 2012-03-30T10:42:28Z [Term] id: GO:0038130 name: ERBB4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000007160, Reactome:R-HSA-1236394] synonym: "ERBB4 signalling pathway" EXACT [GOC:mah] synonym: "HER4 signaling pathway" EXACT [PR:000007160] synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160] is_a: GO:0038127 ! ERBB signaling pathway created_by: rfoulger creation_date: 2012-03-30T10:44:08Z [Term] id: GO:0038131 name: neuregulin receptor activity namespace: molecular_function def: "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328] comment: Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'. synonym: "NRG receptor activity" EXACT [PMID:16460914] synonym: "NRG1 receptor activity" NARROW [PMID:16460914] synonym: "NRG2 receptor activity" NARROW [PMID:16460914] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0038132 ! neuregulin binding created_by: rfoulger creation_date: 2012-03-30T10:47:11Z [Term] id: GO:0038132 name: neuregulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors." [GOC:bf, GOC:signaling] is_a: GO:0019838 ! growth factor binding created_by: rfoulger creation_date: 2012-03-30T10:59:56Z [Term] id: GO:0038133 name: ERBB2-ERBB3 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] synonym: "ERBB2-ERBB3 signalling pathway" EXACT [GOC:mah] synonym: "HER2-HER3 signaling pathway" EXACT [PR:000002082, PR:000007159] is_a: GO:0038128 ! ERBB2 signaling pathway is_a: GO:0038129 ! ERBB3 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:10:44Z [Term] id: GO:0038134 name: ERBB2-EGFR signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] synonym: "EGFR-HER2 signaling pathway" EXACT [PR:000002082, PR:000006933] synonym: "ERBB2-EGFR signalling pathway" EXACT [GOC:mah] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway is_a: GO:0038128 ! ERBB2 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:16:28Z [Term] id: GO:0038135 name: ERBB2-ERBB4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] synonym: "ERBB2-ERBB4 signalling pathway" EXACT [GOC:mah] synonym: "HER2-HER4 signaling pathway" EXACT [PR:000002082, PR:000007160] is_a: GO:0038128 ! ERBB2 signaling pathway is_a: GO:0038130 ! ERBB4 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:19:52Z [Term] id: GO:0038136 name: ERBB3-ERBB4 signaling pathway namespace: biological_process def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977958] synonym: "ERBB3-ERBB4 signalling pathway" EXACT [GOC:mah] synonym: "HER3-HER4 signaling pathway" EXACT [PR:000007159, PR:000007160] is_a: GO:0038129 ! ERBB3 signaling pathway is_a: GO:0038130 ! ERBB4 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:21:19Z [Term] id: GO:0038137 name: ERBB4-EGFR signaling pathway namespace: biological_process def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977959] synonym: "ERBB1-ERBB4 signaling pathway" EXACT [PR:000006933, PR:000007160] synonym: "ERBB4-EGFR signalling pathway" EXACT [GOC:mah] synonym: "HER1-HER4 signaling pathway" EXACT [PR:000006933, PR:000007160] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway is_a: GO:0038130 ! ERBB4 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:30:30Z [Term] id: GO:0038138 name: ERBB4-ERBB4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250220] synonym: "ERBB4 homodimeric signaling pathway" EXACT [PMID:16460914] synonym: "ERBB4-ERBB4 signalling pathway" EXACT [GOC:mah] synonym: "HER4-HER4 signaling pathway" EXACT [PR:000007160] is_a: GO:0038130 ! ERBB4 signaling pathway created_by: rfoulger creation_date: 2012-03-30T11:41:05Z [Term] id: GO:0038139 name: ERBB4-EGFR complex namespace: cellular_component def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1)." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977956] synonym: "EGFR-ERBB4 complex" EXACT [GOC:bf] synonym: "ERBB4:EGFR heterodimer" EXACT [Reactome:R-HSA-1977956] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T01:59:41Z [Term] id: GO:0038140 name: ERBB4-ERBB3 complex namespace: cellular_component def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977955] synonym: "ERBB3-ERBB4 complex" EXACT [GOC:bf] synonym: "ERBB4:ERBB3 heterodimer" EXACT [Reactome:117805.1] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T02:04:16Z [Term] id: GO:0038141 name: ERBB4-ERBB4 complex namespace: cellular_component def: "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4)." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250221] synonym: "ERBB4 homodimer" EXACT [Reactome:R-HSA-1977955] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T02:06:20Z [Term] id: GO:0038142 name: EGFR:ERBB2 complex namespace: cellular_component def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, PMID:1973074, Reactome:R-HSA-1227939, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] synonym: "EGF:EGFR:ERBB2 complex" NARROW [Reactome:R-HSA-1963573] synonym: "EGFR:ERBB2 heterodimer" RELATED [Reactome:R-HSA-1963573] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T02:10:38Z [Term] id: GO:0038143 name: ERBB3:ERBB2 complex namespace: cellular_component def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3." [GOC:signaling, PMID:16460914, PMID:8665853, Reactome:R-HSA-1247502, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] synonym: "EGFR:ERBB2 heterodimer" NARROW [Reactome:R-HSA-1963573] synonym: "NRG1/2:ERBB3:ERBB2" NARROW [Reactome:R-HSA-1247502] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T02:16:56Z [Term] id: GO:0038144 name: ERBB4:ERBB2 complex namespace: cellular_component def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, PMID:16978839, Reactome:R-HSA-1250224, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] synonym: "ERBB4:ERBB2 heterodimer" NARROW [Reactome:R-HSA-1250224] synonym: "NRGs/EGFLs:ERBB4:ERBB2" NARROW [Reactome:R-HSA-1250224] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: rfoulger creation_date: 2012-03-30T02:24:01Z [Term] id: GO:0038145 name: macrophage colony-stimulating factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, PR:000005930, Wikipedia:Macrophage_colony-stimulating_factor] synonym: "M-CSF signaling pathway" EXACT [PMID:12138890] synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus created_by: rfoulger creation_date: 2012-04-27T11:04:18Z [Term] id: GO:0038146 name: chemokine (C-X-C motif) ligand 12 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000006066, Wikipedia:Stromal_cell-derived_factor-1] synonym: "CXCL12 signaling pathway" EXACT [GOC:bf] synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf] synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066] synonym: "stromal cell-derived factor-1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:26:17Z [Term] id: GO:0038147 name: C-X-C motif chemokine 12 receptor activity namespace: molecular_function def: "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:22204316] synonym: "CXCL12 receptor activity" EXACT [GOC:bf] synonym: "CXCR4" NARROW [PMID:22204316] synonym: "CXCR7" NARROW [PMID:22204316] synonym: "SDF-1 receptor activity" RELATED [HGNC:10672, PR:000006066] synonym: "stromal cell-derived factor-1 receptor activity" EXACT [HGNC:10672, PR:000006066] is_a: GO:0016494 ! C-X-C chemokine receptor activity relationship: part_of GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:32:53Z [Term] id: GO:0038148 name: chemokine (C-C motif) ligand 2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000002122, Wikipedia:CCL2] synonym: "CCL2 signaling pathway" EXACT [GOC:bf] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:36:08Z [Term] id: GO:0038149 name: C-C motif chemokine 2 receptor activity namespace: molecular_function def: "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling] synonym: "CCL2 receptor activity" EXACT [GOC:bf] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: part_of GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:37:16Z [Term] id: GO:0038150 name: C-C chemokine receptor CCR2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001199] synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:41:02Z [Term] id: GO:0038151 name: CCL2-activated CCR2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "CCL2/CCR2 signaling pathway" EXACT [GOC:bf] is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway is_a: GO:0038150 ! C-C chemokine receptor CCR2 signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:41:58Z [Term] id: GO:0038152 name: C-C chemokine receptor CCR4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001200] synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200] synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:43:34Z [Term] id: GO:0038153 name: CCL2-activated CCR4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "CCL2/CCR4 signaling pathway" RELATED [GOC:bf] is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway is_a: GO:0038152 ! C-C chemokine receptor CCR4 signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:44:48Z [Term] id: GO:0038154 name: interleukin-11-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-11-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-11-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:48:37Z [Term] id: GO:0038155 name: interleukin-23-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-23-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-23-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:49:56Z [Term] id: GO:0038156 name: interleukin-3-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "IL-3-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-3-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-11T11:50:42Z [Term] id: GO:0038157 name: granulocyte-macrophage colony-stimulating factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors." [GOC:nhn, GOC:signaling, PMID:17027509] synonym: "CSF2 signaling pathway" EXACT [PR:000005931] synonym: "GM-CSF receptor signaling pathway" EXACT [GOC:nhn] synonym: "GM-CSF signaling pathway" EXACT [PR:000005931] synonym: "granulocyte-macrophage colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn] synonym: "granulocyte-macrophage colony-stimulating factor signalling pathway" RELATED [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T01:22:15Z [Term] id: GO:0038158 name: granulocyte colony-stimulating factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R)." [GOC:nhn, GOC:signaling] synonym: "CSF3 signaling pathway" EXACT [PR:000005932] synonym: "G-CSF receptor signaling pathway" EXACT [GOC:nhn] synonym: "G-CSF signaling pathway" EXACT [PR:000005932] synonym: "granulocyte colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn] synonym: "granulocyte colony-stimulating factor signalling pathway" RELATED [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T01:30:28Z [Term] id: GO:0038159 name: C-X-C chemokine receptor CXCR4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "CXCR4 signaling pathway" EXACT [PR:000001208] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T01:33:17Z [Term] id: GO:0038160 name: CXCL12-activated CXCR4 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn] synonym: "CXCL12-activated CXCR4 signalling pathway" EXACT [GOC:bf] is_a: GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway is_a: GO:0038159 ! C-X-C chemokine receptor CXCR4 signaling pathway created_by: rfoulger creation_date: 2012-05-14T01:33:17Z [Term] id: GO:0038161 name: prolactin signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429] synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246] synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T01:52:59Z [Term] id: GO:0038162 name: erythropoietin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:12489509] synonym: "EPO-R signaling pathway" EXACT [PMID:12489509] synonym: "erythropoietin receptor signaling pathway" EXACT [PMID:12489509] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0036018 ! cellular response to erythropoietin created_by: rfoulger creation_date: 2012-05-14T02:28:38Z [Term] id: GO:0038163 name: thrombopoietin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:19630807] synonym: "THPO signaling pathway" EXACT [PR:000016318] synonym: "THPO/MPL signaling pathway" EXACT [PMID:18371409] synonym: "thrombopoietin receptor signaling pathway" EXACT [GOC:nhn, PR:000001939] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T02:45:53Z [Term] id: GO:0038164 name: thrombopoietin receptor activity namespace: molecular_function def: "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19630807] is_a: GO:0004896 ! cytokine receptor activity relationship: part_of GO:0038163 ! thrombopoietin-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T02:46:58Z [Term] id: GO:0038165 name: oncostatin-M-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways." [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586] synonym: "oncostatin-M signaling pathway" EXACT [GOC:bf] synonym: "OSM signaling pathway" EXACT [PMID:10579456, PR:000012059] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-05-14T02:54:30Z [Term] id: GO:0038166 name: angiotensin-activated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869] synonym: "angiotensin II-mediated signaling pathway" EXACT [GOC:bf] synonym: "angiotensin receptor signaling pathway" EXACT [GOC:bf, GOC:mtg_cardiac_conduct_nov11] synonym: "angiotensin-mediated signaling pathway" RELATED [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway relationship: part_of GO:1904385 ! cellular response to angiotensin created_by: rfoulger creation_date: 2012-05-14T03:09:03Z [Term] id: GO:0038167 name: epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB." [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240] synonym: "EGFR signaling pathway via activation of NF-kappaB" EXACT [GOC:bf] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: has_part GO:0051092 ! positive regulation of NF-kappaB transcription factor activity created_by: rfoulger creation_date: 2012-05-15T11:49:30Z [Term] id: GO:0038168 name: epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB." [GOC:bf, PMID:22132240] synonym: "EGFR signaling pathway via IKK-dependent activation of NF-kappaB" EXACT [GOC:bf] synonym: "EGFR signaling pathway via IKK/NF-kappaB cascade" EXACT [GOC:bf] is_a: GO:0038167 ! epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity relationship: has_part GO:0007249 ! I-kappaB kinase/NF-kappaB signaling created_by: rfoulger creation_date: 2012-05-15T12:01:09Z [Term] id: GO:0038169 name: somatostatin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369, PR:000001555] comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. synonym: "SST receptor signaling pathway" EXACT [GOC:bf] synonym: "SSTR signaling pathway" RELATED [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2012-06-12T10:30:01Z [Term] id: GO:0038170 name: somatostatin signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin] synonym: "somatostatin signalling pathway" EXACT [GOC:bf] synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf] synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf] synonym: "somatotrophin release inhibiting factor signaling pathway" EXACT [Wikipedia:Somatostatin] synonym: "SRIF signaling pathway" EXACT [Wikipeda:Somatostatin] synonym: "SST signaling pathway" EXACT [Wikipedia:Somatostatin] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0038169 ! somatostatin receptor signaling pathway created_by: rfoulger creation_date: 2012-06-12T10:33:21Z [Term] id: GO:0038171 name: cannabinoid signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid] synonym: "cannabinoid receptor signaling pathway" EXACT [GOC:bf] synonym: "cannabinoid-activated signaling pathway" EXACT [GOC:bf] synonym: "cannabinoid-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2012-06-12T10:47:53Z [Term] id: GO:0038172 name: interleukin-33-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001389] synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf] synonym: "IL33 signaling pathway" EXACT [PR:000001389] synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc] synonym: "interleukin-33-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-06-12T10:57:35Z [Term] id: GO:0038173 name: interleukin-17A-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001138] synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf] synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A] synonym: "IL17a signaling pathway" EXACT [GOC:jc] synonym: "interleukin-17A signaling pathway" RELATED [GOC:jc] synonym: "interleukin-17A-mediated signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: rfoulger creation_date: 2012-06-12T10:59:01Z [Term] id: GO:0038174 name: interleukin-17A receptor activity namespace: molecular_function def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling, PR:000001138] is_a: GO:0030368 ! interleukin-17 receptor activity relationship: part_of GO:0038173 ! interleukin-17A-mediated signaling pathway created_by: rfoulger creation_date: 2012-06-12T11:01:25Z [Term] id: GO:0038175 name: negative regulation of SREBP signaling pathway in response to increased oxygen levels namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." [GOC:al, PMID:22017871] synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen" RELATED [PMID:22017871] synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels" EXACT [GOC:bf, GOC:vw] is_a: GO:2000639 ! negative regulation of SREBP signaling pathway relationship: part_of GO:0036295 ! cellular response to increased oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:28:59Z [Term] id: GO:0038176 name: positive regulation of SREBP signaling pathway in response to decreased oxygen levels namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels." [GOC:al, PMID:22017871] synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen" RELATED [PMID:22017871] synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels" EXACT [GOC:bf, GOC:vw] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus is_a: GO:2000640 ! positive regulation of SREBP signaling pathway relationship: part_of GO:0036294 ! cellular response to decreased oxygen levels created_by: rfoulger creation_date: 2012-07-20T01:30:25Z [Term] id: GO:0038177 name: death receptor agonist activity namespace: molecular_function def: "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." [GOC:mtg_apoptosis, GOC:pr] synonym: "death receptor activator activity" EXACT [GOC:pr] is_a: GO:0048018 ! receptor ligand activity relationship: has_part GO:0005123 ! death receptor binding created_by: rfoulger creation_date: 2012-09-20T12:52:00Z [Term] id: GO:0038178 name: complement component C5a signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor." [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a] synonym: "complement component C5a-induced signaling pathway" EXACT [GOC:jc] is_a: GO:0002430 ! complement receptor mediated signaling pathway is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2012-09-21T10:55:00Z [Term] id: GO:0038179 name: neurotrophin signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, PR:000021998, Wikipedia:Neurotrophin] comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors. synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586] is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: part_of GO:0071363 ! cellular response to growth factor stimulus created_by: rfoulger creation_date: 2013-03-27T17:22:44Z [Term] id: GO:0038180 name: nerve growth factor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, PR:000011194, Wikipedia:Nerve_growth_factor] comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase. synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf] synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor] is_a: GO:0038179 ! neurotrophin signaling pathway relationship: part_of GO:1990090 ! cellular response to nerve growth factor stimulus created_by: rfoulger creation_date: 2013-05-15T11:04:05Z [Term] id: GO:0038181 name: bile acid receptor activity namespace: molecular_function def: "Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile." [GOC:bf, PMID:10334992, PMID:12718893] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0032052 ! bile acid binding relationship: part_of GO:0038183 ! bile acid signaling pathway created_by: rfoulger creation_date: 2013-05-16T10:27:02Z [Term] id: GO:0038182 name: G protein-coupled bile acid receptor activity namespace: molecular_function def: "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, PMID:12524422, Wikipedia:G_protein-coupled_bile_acid_receptor] synonym: "cell surface bile acid receptor" BROAD [GOC:bf] synonym: "G-protein coupled bile acid receptor activity" EXACT [] synonym: "membrane bile acid receptor activity" BROAD [PMID:12419312] xref: Wikipedia:G_protein-coupled_bile_acid_receptor is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0038181 ! bile acid receptor activity relationship: part_of GO:0038184 ! cell surface bile acid receptor signaling pathway created_by: rfoulger creation_date: 2013-05-16T10:29:42Z [Term] id: GO:0038183 name: bile acid signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a bile acid to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:12016314] is_a: GO:0007165 ! signal transduction created_by: rfoulger creation_date: 2013-05-16T10:35:10Z [Term] id: GO:0038184 name: cell surface bile acid receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12419312, PMID:19442546] synonym: "membrane bile acid receptor signaling pathway" RELATED [GOC:bf] is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0038183 ! bile acid signaling pathway created_by: rfoulger creation_date: 2013-05-16T11:00:42Z [Term] id: GO:0038185 name: intracellular bile acid receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:10334992] synonym: "nuclear bile acid receptor signaling pathway" RELATED [] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0038183 ! bile acid signaling pathway created_by: rfoulger creation_date: 2013-05-16T11:08:02Z [Term] id: GO:0038186 name: lithocholic acid receptor activity namespace: molecular_function def: "Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity." [GOC:bf, PMID:12016314, PMID:12419312] synonym: "LCA receptor activity" EXACT [PMID:10334992] is_a: GO:0038181 ! bile acid receptor activity relationship: has_part GO:1902121 ! lithocholic acid binding created_by: rfoulger creation_date: 2013-05-16T11:13:38Z [Term] id: GO:0038187 name: pattern recognition receptor activity namespace: molecular_function alt_id: GO:0008329 def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from host damaged cells, to initiate an innate immune response." [GOC:ar, GOC:bf, Wikipedia:Pattern_recognition_receptor] comment: Merged terms, edited definiton and synonyms, see https://github.com/geneontology/go-ontology/issues/17995. synonym: "damage associated molecular pattern receptor activity" NARROW [] synonym: "DAMP receptor activity" NARROW [] synonym: "macrophage receptor activity" RELATED [] synonym: "MAMP receptor activity" NARROW [] synonym: "microbe-associated molecular pattern receptor activity" NARROW [] synonym: "PAMP receptor activity" NARROW [] synonym: "pathogen associated molecular pattern receptor activity" NARROW [] synonym: "PRR" EXACT [] synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor] synonym: "signaling pattern recognition receptor activity" RELATED [] is_a: GO:0038023 ! signaling receptor activity created_by: rfoulger creation_date: 2013-05-29T15:24:44Z [Term] id: GO:0038188 name: cholecystokinin signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of cholecystokinin binding to a receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948] synonym: "CCK signaling" EXACT [PMID:11181948, Wikipedia:Cholecystokinin] synonym: "cholecystokinin receptor signaling pathway" RELATED [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2013-07-01T13:05:46Z [Term] id: GO:0038189 name: neuropilin signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:12852851] synonym: "Npn signaling" EXACT [PMID:12852851] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2013-08-01T16:02:10Z [Term] id: GO:0038190 name: VEGF-activated neuropilin signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:rl, PMID:12852851] synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway" RELATED [GOC:bf] synonym: "VEGF-Npn-1 signaling" NARROW [PMID:12852851] is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway is_a: GO:0038189 ! neuropilin signaling pathway relationship: has_part GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: rfoulger creation_date: 2013-08-01T16:06:49Z [Term] id: GO:0038191 name: neuropilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the neuropilin family." [GOC:bf, PMID:23871893] synonym: "neuropilin-binding" EXACT [PMID:12852851] synonym: "Nrp binding" EXACT [PMID:23871893] synonym: "Nrp ligand" NARROW [PMID:23871893] is_a: GO:0005102 ! signaling receptor binding created_by: rfoulger creation_date: 2013-08-01T16:11:33Z [Term] id: GO:0038192 name: gastric inhibitory peptide signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a gastric inhibitory peptide (GIP) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15955806] synonym: "gastric inhibitory polypeptide receptor signaling pathway" EXACT [GOC:nhn] synonym: "GIP signaling" EXACT [PMID:19251046] synonym: "glucose-dependent insulinotropic polypeptide signaling" EXACT [PMID:19251046] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2013-09-02T15:57:49Z [Term] id: GO:0038193 name: thromboxane A2 signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of thromboxane A2 binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15893915] synonym: "TXA(2) receptor signaling" EXACT [PMID:15893915] synonym: "TXA2 signaling" EXACT [PMID:15242977] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2013-09-02T16:07:01Z [Term] id: GO:0038194 name: thyroid-stimulating hormone signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:10809230] synonym: "thyrotropin signaling pathway" EXACT [GOC:gap, PMID:10809230] synonym: "TSH signaling pathway" EXACT [PMID:10809230] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger creation_date: 2013-10-28T09:03:48Z [Term] id: GO:0038195 name: urokinase plasminogen activator signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of urokinase plasminogen activator to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:9417082] synonym: "uPA signaling pathway" EXACT [PMID:9417082] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: rfoulger creation_date: 2013-10-28T09:14:13Z [Term] id: GO:0038196 name: type III interferon signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far." [GOC:pg, GOC:signaling] synonym: "interferon lambda signaling pathway" NARROW [PR:000001362] synonym: "type III interferon-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071358 ! cellular response to type III interferon created_by: rfoulger creation_date: 2013-11-27T14:25:49Z [Term] id: GO:0038197 name: type I interferon receptor complex namespace: cellular_component def: "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:cjm, GOC:signaling, PMID:17502368] synonym: "interferon-alpha/beta receptor complex" NARROW [GOC:bf] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: rfoulger creation_date: 2013-11-27T14:53:50Z [Term] id: GO:0038198 name: auxin receptor activity namespace: molecular_function def: "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)." [GOC:signaling, PMID:15917797] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0010011 ! auxin binding relationship: part_of GO:0009734 ! auxin-activated signaling pathway created_by: rfoulger creation_date: 2013-12-05T15:47:42Z [Term] id: GO:0038199 name: ethylene receptor activity namespace: molecular_function def: "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity." [GOC:signaling, PMID:22467798, PMID:24012247] synonym: "C2H4 receptor activity" EXACT [PMID:24012247] synonym: "ethylene response sensor" RELATED [PMID:22467798] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0051740 ! ethylene binding relationship: part_of GO:0009873 ! ethylene-activated signaling pathway created_by: rfoulger creation_date: 2013-12-05T16:06:13Z [Term] id: GO:0038200 name: ethylene receptor histidine kinase activity namespace: molecular_function def: "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:signaling, PMID:22467798] is_a: GO:0038199 ! ethylene receptor activity relationship: has_part GO:0004673 ! protein histidine kinase activity created_by: rfoulger creation_date: 2013-12-05T16:25:15Z [Term] id: GO:0038201 name: TOR complex namespace: cellular_component def: "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K." [Wikipedia:MTORC1, Wikipedia:MTORC2] synonym: "mTOR complex" NARROW [Wikipedia:MTORC1] synonym: "target of rapamycin complex" EXACT [GOC:bf] synonym: "TOR signaling complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: rfoulger creation_date: 2013-12-09T14:38:09Z [Term] id: GO:0038202 name: TORC1 signaling namespace: biological_process def: "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] synonym: "TORC1 signal transduction" EXACT [GOC:signaling] is_a: GO:0031929 ! TOR signaling created_by: rfoulger creation_date: 2013-12-09T14:43:29Z [Term] id: GO:0038203 name: TORC2 signaling namespace: biological_process def: "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] synonym: "TORC2 signal transduction" EXACT [GOC:signaling] is_a: GO:0031929 ! TOR signaling created_by: rfoulger creation_date: 2013-12-09T14:43:29Z [Term] id: GO:0039003 name: pronephric field specification namespace: biological_process def: "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney field specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072004 ! kidney field specification created_by: rfoulger creation_date: 2010-07-02T09:28:16Z [Term] id: GO:0039004 name: specification of pronephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0039005 ! specification of pronephric tubule identity is_a: GO:0072082 ! specification of proximal tubule identity is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development relationship: part_of GO:0039011 ! pronephric proximal tubule morphogenesis created_by: rfoulger creation_date: 2010-07-02T09:30:30Z [Term] id: GO:0039005 name: specification of pronephric tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis created_by: rfoulger creation_date: 2010-07-02T09:33:56Z [Term] id: GO:0039006 name: pronephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10] synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis relationship: part_of GO:0072116 ! pronephros formation created_by: rfoulger creation_date: 2010-07-02T09:37:27Z [Term] id: GO:0039007 name: pronephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0039019 ! pronephric nephron development relationship: part_of GO:0072114 ! pronephros morphogenesis created_by: rfoulger creation_date: 2010-07-02T09:38:53Z [Term] id: GO:0039008 name: pronephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0039007 ! pronephric nephron morphogenesis relationship: part_of GO:0039020 ! pronephric nephron tubule development created_by: rfoulger creation_date: 2010-07-02T09:45:55Z [Term] id: GO:0039009 name: rectal diverticulum development namespace: biological_process def: "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015] synonym: "pronephric rectal diverticulum development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T09:48:58Z [Term] id: GO:0039010 name: specification of pronephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0039005 ! specification of pronephric tubule identity is_a: GO:0072084 ! specification of distal tubule identity is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development relationship: part_of GO:0039013 ! pronephric distal tubule morphogenesis created_by: rfoulger creation_date: 2010-07-02T09:51:28Z [Term] id: GO:0039011 name: pronephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis relationship: part_of GO:0035776 ! pronephric proximal tubule development created_by: rfoulger creation_date: 2010-07-02T09:53:12Z [Term] id: GO:0039012 name: pronephric sinus development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T09:55:23Z [Term] id: GO:0039013 name: pronephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] is_a: GO:0039008 ! pronephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis relationship: part_of GO:0035777 ! pronephric distal tubule development created_by: rfoulger creation_date: 2010-07-02T09:58:03Z [Term] id: GO:0039014 name: cell differentiation involved in pronephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0048793 ! pronephros development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T09:59:25Z [Term] id: GO:0039015 name: cell proliferation involved in pronephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10] synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0048793 ! pronephros development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:01:49Z [Term] id: GO:0039016 name: cell-cell signaling involved in pronephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0048793 ! pronephros development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:03:16Z [Term] id: GO:0039017 name: pattern specification involved in pronephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: part_of GO:0048793 ! pronephros development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:04:39Z [Term] id: GO:0039018 name: nephrostome development namespace: biological_process def: "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:08:16Z [Term] id: GO:0039019 name: pronephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785] is_a: GO:0072006 ! nephron development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:10:20Z [Term] id: GO:0039020 name: pronephric nephron tubule development namespace: biological_process def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0039019 ! pronephric nephron development created_by: rfoulger creation_date: 2010-07-02T10:11:36Z [Term] id: GO:0039021 name: pronephric glomerulus development namespace: biological_process def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557] comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0039019 ! pronephric nephron development created_by: rfoulger creation_date: 2010-07-02T10:13:38Z [Term] id: GO:0039022 name: pronephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150] is_a: GO:0072176 ! nephric duct development relationship: part_of GO:0048793 ! pronephros development created_by: rfoulger creation_date: 2010-07-02T10:15:03Z [Term] id: GO:0039023 name: pronephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150] is_a: GO:0072178 ! nephric duct morphogenesis relationship: part_of GO:0039022 ! pronephric duct development relationship: part_of GO:0072114 ! pronephros morphogenesis created_by: rfoulger creation_date: 2010-07-02T10:18:09Z [Term] id: GO:0039501 name: suppression by virus of host type I interferon production namespace: biological_process def: "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1113, VZ:875] synonym: "negative regulation by virus of host type I interferon production" EXACT [GOC:bf] synonym: "suppression by virus of host interferon type I production" EXACT [GOC:bf] synonym: "suppression by virus of host type I IFN production" EXACT [GOC:bf] xref: VZ:875 "Inhibition of host IFN-mediated response initiation by virus" is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0046775 ! suppression by virus of host cytokine production created_by: rfoulger creation_date: 2011-05-11T03:53:20Z [Term] id: GO:0039502 name: suppression by virus of host type I interferon-mediated signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1114, VZ:883] synonym: "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114] synonym: "negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf] xref: VZ:883 "Inhibition of host IFN-mediated response initiation by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0060339 ! negative regulation of type I interferon-mediated signaling pathway is_a: GO:0075114 ! suppression by symbiont of host transmembrane receptor-mediated signal transduction intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0060337 ! type I interferon signaling pathway created_by: rfoulger creation_date: 2011-05-11T04:06:28Z [Term] id: GO:0039503 name: suppression by virus of host innate immune response namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090] synonym: "inhibition of host innate immune response by virus" EXACT [UniProtKB-KW:KW-1090] synonym: "negative regulation by virus of host innate immune response" EXACT [GOC:bf] synonym: "negative regulation by virus of host innate immunity" EXACT [GOC:bf] synonym: "suppression by virus of host innate immunity" EXACT [GOC:pg] is_a: GO:0030683 ! mitigation of host immune response by virus is_a: GO:0052170 ! suppression by symbiont of host innate immune response is_a: GO:0075528 ! modulation by virus of host immune response created_by: rfoulger creation_date: 2011-05-11T04:31:17Z [Term] id: GO:0039504 name: suppression by virus of host adaptive immune response namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1080] synonym: "inhibition of host adaptive immune response by virus" EXACT [UniProtKB-KW:KW-1080] synonym: "negative regulation by virus of host adaptive immune response" EXACT [GOC:bf] synonym: "negative regulation by virus of host adaptive immunity" EXACT [GOC:bf] synonym: "suppression by virus of host acquired immune response" EXACT [ISBN:068340007X] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0030683 ! mitigation of host immune response by virus is_a: GO:0052562 ! suppression by symbiont of host immune response is_a: GO:0075528 ! modulation by virus of host immune response intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0002250 ! adaptive immune response created_by: rfoulger creation_date: 2011-05-11T04:41:54Z [Term] id: GO:0039505 name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf, UniProtKB-KW:KW-1116, VZ:820] synonym: "inhibition of host MHC class II molecule presentation by virus" RELATED [UniProtKB-KW:KW-1116] xref: VZ:820 "Inhibition of host MHC class II molecule presentation by virus" is_a: GO:0002587 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class II is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II created_by: rfoulger creation_date: 2011-06-02T02:34:51Z [Term] id: GO:0039506 name: modulation by virus of host molecular function namespace: biological_process def: "The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp] synonym: "modification by virus of host protein function" EXACT [GOC:bf] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0003674 ! molecular_function created_by: rfoulger creation_date: 2011-06-02T02:38:42Z [Term] id: GO:0039507 name: suppression by virus of host molecular function namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp] synonym: "down regulation by virus of host protein function" EXACT [GOC:bf] synonym: "down-regulation by virus of host protein function" EXACT [GOC:bf] synonym: "inhibition by virus of host protein function" NARROW [GOC:bf] synonym: "inhibition of host protein function" NARROW [GOC:bf] synonym: "negative regulation by virus of host molecular function" EXACT [GOC:bf] synonym: "negative regulation by virus of host protein function" EXACT [GOC:bf] is_a: GO:0039506 ! modulation by virus of host molecular function is_a: GO:0052056 ! negative regulation by symbiont of host molecular function created_by: rfoulger creation_date: 2011-06-02T02:47:03Z [Term] id: GO:0039508 name: suppression by virus of host receptor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "downregulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "inhibition by virus of host receptor activity" NARROW [GOC:bf] synonym: "negative regulation by virus of host receptor activity" EXACT [GOC:bf] synonym: "suppression by virus of host receptor function" EXACT [GOC:bf] synonym: "viral inhibition of host receptor" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function created_by: rfoulger creation_date: 2011-06-02T03:09:37Z [Term] id: GO:0039509 name: suppression by virus of host pattern recognition receptor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp] synonym: "down regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "down-regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "inhibition by virus of host pattern recognition receptor activity" NARROW [GOC:rf] synonym: "negative regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] synonym: "suppression by virus of host pattern recognition receptor function" EXACT [GOC:bf] synonym: "viral inhibition of host pattern recognition receptor activity" NARROW [GOC:bf] is_a: GO:0039508 ! suppression by virus of host receptor activity created_by: rfoulger creation_date: 2011-06-02T03:11:23Z [Term] id: GO:0039510 name: suppression by virus of host ATP-dependent RNA helicase activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] synonym: "downregulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] synonym: "inhibition by virus of host ATP-dependent RNA helicase activity" NARROW [GOC:bf] synonym: "negative regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] is_a: GO:0039513 ! suppression by virus of host catalytic activity created_by: rfoulger creation_date: 2011-06-16T02:11:00Z [Term] id: GO:0039511 name: suppression by virus of host interferon receptor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843] synonym: "down-regulation by virus of host interferon receptor activity" EXACT [GOC:bf] synonym: "downregulation by virus of host interferon receptor activity" EXACT [GOC:bf] synonym: "inhibition by virus of host interferon receptor activity" NARROW [GOC:bf] synonym: "inhibition of host interferon receptors by virus" EXACT [UniProtKB-KW:KW-1091] synonym: "negative regulation by virus of host interferon receptor activity" EXACT [GOC:bf] xref: VZ:843 "Inhibition of host interferon receptors by virus" is_a: GO:0039508 ! suppression by virus of host receptor activity created_by: rfoulger creation_date: 2011-06-16T02:24:05Z [Term] id: GO:0039512 name: suppression by virus of host protein tyrosine kinase activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] synonym: "downregulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] synonym: "inhibition by virus of host protein tyrosine kinase activity" NARROW [GOC:bf] synonym: "negative regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] is_a: GO:0039584 ! suppression by virus of host protein kinase activity created_by: rfoulger creation_date: 2011-06-16T02:27:26Z [Term] id: GO:0039513 name: suppression by virus of host catalytic activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity." [GOC:bf] synonym: "down-regulation by virus of host enzyme activity" EXACT [GOC:bf] synonym: "downregulation by virus of host catalytic activity" EXACT [GOC:bf] synonym: "inhibition by virus of host catalytic activity" NARROW [GOC:bf] synonym: "negative regulation by virus of host catalytic activity" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039516 ! modulation by virus of host catalytic activity is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity created_by: rfoulger creation_date: 2011-06-16T02:32:49Z [Term] id: GO:0039514 name: suppression by virus of host JAK-STAT cascade namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] synonym: "downregulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] synonym: "inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf] synonym: "negative regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway created_by: rfoulger creation_date: 2011-06-16T02:48:03Z [Term] id: GO:0039516 name: modulation by virus of host catalytic activity namespace: biological_process def: "The process in which a virus effects a change in host enzyme activity." [GOC:bf, GOC:sp] synonym: "modulation of catalytic activity of host by virus" EXACT [GOC:bf] synonym: "regulation by virus of host catalytic activity" EXACT [GOC:bf] synonym: "regulation of host catalytic activity by virus" EXACT [GOC:bf] is_a: GO:0039506 ! modulation by virus of host molecular function is_a: GO:0052148 ! modulation by symbiont of host catalytic activity intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0003824 ! catalytic activity created_by: rfoulger creation_date: 2011-06-16T02:59:35Z [Term] id: GO:0039517 name: modulation by virus of host protein serine/threonine phosphatase activity namespace: biological_process def: "The process in which a virus effects a change in host protein serine/threonine phosphatase activity." [GOC:bf, GOC:sp] synonym: "modulation by virus of protein serine/threonine phosphatase activity in host" EXACT [GOC:bf] synonym: "regulation by virus of host protein serine/threonine phosphatase activity" EXACT [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0039516 ! modulation by virus of host catalytic activity is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0004722 ! protein serine/threonine phosphatase activity relationship: regulates GO:0004722 ! protein serine/threonine phosphatase activity created_by: rfoulger creation_date: 2011-06-16T03:04:14Z [Term] id: GO:0039518 name: suppression by virus of host cytokine activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity." [GOC:bf, GOC:sp] synonym: "down-regulation by virus of host cytokine activity" EXACT [GOC:bf] synonym: "downregulation by virus of host cytokine activity" EXACT [GOC:bf] synonym: "inhibition by virus of host cytokine activity" NARROW [GOC:bf] synonym: "negative regulation by virus of host cytokine activity" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function created_by: rfoulger creation_date: 2011-06-22T04:09:41Z [Term] id: GO:0039519 name: modulation by virus of host autophagy namespace: biological_process def: "Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp] synonym: "regulation by virus of host autophagy" EXACT [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0075071 ! modulation by symbiont of host autophagy is_a: GO:1904092 ! regulation of autophagic cell death intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0048102 ! autophagic cell death created_by: rfoulger creation_date: 2011-06-22T04:19:19Z [Term] id: GO:0039520 name: induction by virus of host autophagy namespace: biological_process def: "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846] synonym: "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072] synonym: "positive regulation by virus of host autophagy" BROAD [GOC:bf] xref: VZ:846 "Activation of host autophagy by virus" is_a: GO:0039519 ! modulation by virus of host autophagy is_a: GO:0075044 ! positive regulation by symbiont of host autophagy created_by: rfoulger creation_date: 2011-06-22T04:24:47Z [Term] id: GO:0039521 name: suppression by virus of host autophagy namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1083, VZ:845] synonym: "inhibition by virus of host autophagy" EXACT [GOC:bf] synonym: "inhibition of host autophagy by virus" EXACT [UniProtKB-KW:KW-1083] synonym: "negative regulation by virus of host autophagy" BROAD [GOC:bf] xref: VZ:845 "Inhibition of host autophagy by virus" is_a: GO:0039519 ! modulation by virus of host autophagy is_a: GO:0140321 ! negative regulation by symbiont of host autophagy created_by: rfoulger creation_date: 2011-06-22T04:30:11Z [Term] id: GO:0039522 name: suppression by virus of host mRNA export from nucleus namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1099, VZ:902] synonym: "inhibition by virus of host mRNA nuclear export" EXACT [GOC:bf] synonym: "inhibition of host mRNA nuclear export by virus" EXACT [UniProtKB-KW:KW-1099] synonym: "negative regulation by virus of host mRNA nuclear export" BROAD [GOC:bf] synonym: "suppression of host mRNA nuclear export by virus" EXACT [GOC:bf] xref: VZ:902 "Inhibition of host mRNA nuclear export by virus" is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052038 ! modulation by symbiont of host intracellular transport created_by: rfoulger creation_date: 2011-06-22T04:34:14Z [Term] id: GO:0039523 name: suppression by virus of host RNA polymerase II activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1104, VZ:905] synonym: "inhibition of host RNA polymerase II activity by virus" EXACT [GOC:bf] synonym: "inhibition of host RNA polymerase II by virus" EXACT [UniProtKB-KW:KW-1104] synonym: "negative regulation by virus of host RNA polymerase II activity" BROAD [GOC:bf] xref: VZ:905 "Inhibition of host RNA polymerase II by virus" is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2011-06-22T04:38:59Z [Term] id: GO:0039524 name: suppression by virus of host mRNA processing namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1103, VZ:903] synonym: "inhibition by virus of host mRNA processing" EXACT [GOC:bf] synonym: "inhibition of host mRNA processing by virus" EXACT [GOC:bf] synonym: "inhibition of host pre-mRNA processing by virus" EXACT [UniProtKB-KW:KW-1103, VZ:903] synonym: "negative regulation by virus of host mRNA processing" BROAD [GOC:bf] xref: VZ:903 "Inhibition of host pre-mRNA processing by virus" is_a: GO:0039657 ! suppression by virus of host gene expression is_a: GO:0046778 ! modification by virus of host mRNA processing is_a: GO:0050686 ! negative regulation of mRNA processing created_by: rfoulger creation_date: 2011-06-22T04:51:55Z [Term] id: GO:0039525 name: modulation by virus of host chromatin organization namespace: biological_process def: "Any process in which a virus effects a change in the organization of chromatin in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1122] synonym: "modulation by virus of host chromatin organisation" EXACT [GOC:mah] synonym: "modulation of host chromatin by virus" EXACT [UniProtKB-KW:KW-1122] synonym: "modulation of host chromatin structure by virus" EXACT [GOC:bf] synonym: "regulation by virus of host chromatin organization" RELATED [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0006325 ! chromatin organization created_by: rfoulger creation_date: 2011-06-22T05:11:13Z [Term] id: GO:0039526 name: modulation by virus of host apoptotic process namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells." [GOC:bf, GOC:mtg_apoptosis, GOC:sp, UniProtKB-KW:KW-1119] synonym: "modulation by virus of host apoptosis" EXACT [] synonym: "modulation of host cell apoptosis by virus" EXACT [UniProtKB-KW:KW-1119] synonym: "regulation by virus of host apoptosis" EXACT [GOC:bf] xref: VZ:1581 "Apoptosis modulation" is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052150 ! modulation by symbiont of host apoptotic process intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0006915 ! apoptotic process created_by: rfoulger creation_date: 2011-06-22T05:22:53Z [Term] id: GO:0039527 name: suppression by virus of host TRAF-mediated signal transduction namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host." [GOC:bf, GOC:sp] synonym: "inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf] synonym: "negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf] synonym: "suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway created_by: rfoulger creation_date: 2011-06-22T05:30:41Z [Term] id: GO:0039528 name: cytoplasmic pattern recognition receptor signaling pathway in response to virus namespace: biological_process def: "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363] comment: This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2. synonym: "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW [PMID:17328678] synonym: "cytoplasmic pattern recognition receptor signalling pathway in response to virus" EXACT [GOC:mah] synonym: "RIG-I-like receptor (RLR) signaling pathway" NARROW [PMID:21626883] synonym: "RIG-I/MDA5 signaling pathway" NARROW [PMID:21187438] synonym: "RIG-like helicase signaling pathway" NARROW [PMID:18272355] synonym: "RIG-like receptor signaling pathway" NARROW [PMID:19531363] synonym: "RLH signaling pathway" NARROW [PMID:18272355] synonym: "RLR signaling pathway" NARROW [PMID:19531363] synonym: "virus-induced cytoplasmic pattern recognition receptor signaling pathway" EXACT [GOC:bf] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0098586 ! cellular response to virus intersection_of: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway intersection_of: part_of GO:0051607 ! defense response to virus relationship: part_of GO:0051607 ! defense response to virus created_by: rfoulger creation_date: 2011-12-20T02:43:15Z [Term] id: GO:0039529 name: RIG-I signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580] comment: The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect. synonym: "DDX58 signaling pathway" EXACT [HGNC:19102] synonym: "retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] synonym: "RIG-I signalling pathway" EXACT [GOC:mah] is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus created_by: rfoulger creation_date: 2011-12-20T03:11:06Z [Term] id: GO:0039530 name: MDA-5 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:19620789] synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873] synonym: "MDA-5 signalling pathway" EXACT [GOC:mah] synonym: "MDA5 signaling pathway" NARROW [PMID:17328678] synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus created_by: rfoulger creation_date: 2011-12-20T03:14:52Z [Term] id: GO:0039531 name: regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl] synonym: "regulation of MAV signaling" RELATED [GOC:bf, GOC:sp] synonym: "regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050688 ! regulation of defense response to virus is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus relationship: regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus created_by: rfoulger creation_date: 2012-01-03T11:06:56Z [Term] id: GO:0039532 name: negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl] synonym: "negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf] synonym: "negative regulation of MAVS signaling" RELATED [GOC:bf] synonym: "negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0050687 ! negative regulation of defense response to virus is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus relationship: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus created_by: rfoulger creation_date: 2012-01-03T11:14:48Z [Term] id: GO:0039533 name: regulation of MDA-5 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl] synonym: "regulation of IFIH1 signaling pathway" EXACT [HGNC:18873] synonym: "regulation of MDA-5 signalling pathway" EXACT [GOC:mah] synonym: "regulation of MDA5 signaling pathway" EXACT [PMID:17328678] synonym: "regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039530 ! MDA-5 signaling pathway relationship: regulates GO:0039530 ! MDA-5 signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:17:31Z [Term] id: GO:0039534 name: negative regulation of MDA-5 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl] synonym: "negative regulation of IFIH1 signaling pathway" EXACT [HGNC:18873] synonym: "negative regulation of MDA-5 signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of MDA5 signaling pathway" EXACT [PMID:17328678] synonym: "negative regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0039533 ! regulation of MDA-5 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039530 ! MDA-5 signaling pathway relationship: negatively_regulates GO:0039530 ! MDA-5 signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:21:20Z [Term] id: GO:0039535 name: regulation of RIG-I signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl] synonym: "regulation of DDX58 signaling pathway" EXACT [HGNC:19102] synonym: "regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] synonym: "regulation of RIG-I signalling pathway" EXACT [GOC:mah] is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039529 ! RIG-I signaling pathway relationship: regulates GO:0039529 ! RIG-I signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:24:29Z [Term] id: GO:0039536 name: negative regulation of RIG-I signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl] synonym: "negative regulation of DDX58 signaling pathway" EXACT [HGNC:19102] synonym: "negative regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] synonym: "negative regulation of RIG-I signalling pathway" EXACT [GOC:mah] is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0039535 ! regulation of RIG-I signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039529 ! RIG-I signaling pathway relationship: negatively_regulates GO:0039529 ! RIG-I signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:27:51Z [Term] id: GO:0039537 name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] synonym: "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf] synonym: "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf] synonym: "suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf] synonym: "suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf] synonym: "suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf] synonym: "suppression by virus of host RLR signaling pathway" RELATED [GOC:bf] synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0075111 ! suppression by symbiont of host receptor-mediated signal transduction created_by: rfoulger creation_date: 2012-01-03T11:47:05Z [Term] id: GO:0039538 name: suppression by virus of host RIG-I signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] synonym: "inhibition by virus of host RIG-I signaling" EXACT [GOC:bf] synonym: "suppression by virus of host DDX58 signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host RIG-I signalling pathway" EXACT [GOC:mah] is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:50:17Z [Term] id: GO:0039539 name: suppression by virus of host MDA-5 signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] synonym: "inhibition by virus of host MDA-5 signaling" EXACT [GOC:bf] synonym: "suppression by virus of host IFIH1 signaling pathway" EXACT [GOC:bf] synonym: "suppression by virus of host MDA-5 signalling pathway" EXACT [GOC:mah] is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway created_by: rfoulger creation_date: 2012-01-03T11:51:36Z [Term] id: GO:0039540 name: suppression by virus of host RIG-I activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1088, VZ:856] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I). synonym: "inhibition by virus of host DDX58 activity" EXACT [GOC:sp] synonym: "inhibition by virus of host RIG-I" RELATED [GOC:bf] synonym: "inhibition of host DDX58/RIG-I by virus" EXACT [UniProtKB-KW:KW-1088] xref: VZ:856 "Inhibition of host RIG-I by virus" is_a: GO:0039509 ! suppression by virus of host pattern recognition receptor activity is_a: GO:0039538 ! suppression by virus of host RIG-I signaling pathway created_by: rfoulger creation_date: 2012-01-18T02:24:20Z [Term] id: GO:0039541 name: obsolete suppression by virus of host RIG-I via RIG-I binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by interacting selectively and non-covalently with RIG-I itself." [PMID:19193793, PMID:20007272, VZ:856] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of host DDX58:MAVS binding" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-19T02:14:20Z [Term] id: GO:0039542 name: obsolete suppression by virus of host RIG-I K63-linked ubiquitination namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity." [PMID:19454348, PMID:21890623] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of host DDX58 K63-linked ubiquitination" EXACT [GOC:bf] synonym: "inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination" BROAD [GOC:bf] synonym: "inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I" EXACT [PMID:19454348] is_obsolete: true created_by: rfoulger creation_date: 2012-01-18T02:30:29Z [Term] id: GO:0039543 name: obsolete suppression by virus of host RIG-I activity by viral RNA 5' processing namespace: biological_process def: "OBSOLETE. The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition." [PMID:18446221, VZ:856] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host RIG-I activity by inhibition of RNA binding" NARROW [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-18T02:30:29Z [Term] id: GO:0039544 name: obsolete suppression by virus of host RIG-I activity by RIG-I proteolysis namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction." [PMID:19628239] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "cleavage of RIG-I by viral proteinase" EXACT [PMID:19628239] synonym: "inhibition by virus of host RIG-I activity by RIG-I proteolysis" RELATED [VZ:856] is_obsolete: true created_by: rfoulger creation_date: 2012-01-18T02:30:29Z [Term] id: GO:0039545 name: suppression by virus of host MAVS activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of MAVS (mitochondrial antiviral signaling protein), a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [UniProtKB-KW:KW-1097, VZ:704] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition of host MAVS by virus" EXACT [UniProtKB-KW:KW-1097, VZ:704] synonym: "suppression by virus of host mitochondrial antiviral-signaling protein" EXACT [PR:000010210] xref: VZ:704 "Inhibition of host MAVS by virus" is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway created_by: rfoulger creation_date: 2012-01-19T02:37:20Z [Term] id: GO:0039546 name: obsolete suppression by virus of host MAVS activity by MAVS proteolysis namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling." [PMID:21436888, PMID:22238314] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "viral protease cleavage of MAVS" EXACT [PMID:22238314] is_obsolete: true created_by: rfoulger creation_date: 2012-01-19T02:49:44Z [Term] id: GO:0039547 name: suppression by virus of host TRAF activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components." [GOC:bf, UniProtKB-KW:KW-1110, VZ:715] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition of host TRAFs by virus" EXACT [UniProtKB-KW:KW-1110] is_a: GO:0039507 ! suppression by virus of host molecular function relationship: part_of GO:0039527 ! suppression by virus of host TRAF-mediated signal transduction created_by: rfoulger creation_date: 2012-01-19T03:12:15Z [Term] id: GO:0039548 name: suppression by virus of host IRF3 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562, UniProtKB-KW:KW-1092, VZ:757] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition of host IRF3 by virus" EXACT [UniProtKB-KW:KW-1092] synonym: "Inhibition of IRF3-dependent antiviral response" BROAD [PMID:19125153] synonym: "suppression by virus of host interferon regulatory factor 3" EXACT [PR:000002045] xref: VZ:757 "Inhibition of host IRF3 by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2012-01-19T04:04:26Z [Term] id: GO:0039549 name: obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes." [PMID:11124948, PMID:12829834, PMID:20631144, PMID:9566918] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition of phosphorylation-induced activation of host IRF3" RELATED [PMID:11124948] synonym: "inhibition of virus-induced IRF-3 phosphorylation" BROAD [PMID:12829834] is_obsolete: true created_by: rfoulger creation_date: 2012-01-19T04:27:06Z [Term] id: GO:0039550 name: obsolete suppression by virus of host IRF3 activity by inhibition of DNA binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites." [PMID:21632562] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of host IRF3-DNA binding" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-01-19T04:27:25Z [Term] id: GO:0039551 name: obsolete suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome." [VZ:757] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "promotion by virus of proteosome-dependent IRF3 degradation" EXACT [VZ:757] is_obsolete: true created_by: rfoulger creation_date: 2012-01-20T11:35:33Z [Term] id: GO:0039552 name: RIG-I binding namespace: molecular_function def: "Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA." [GOC:bf, PMID:21233210] synonym: "DDX58 binding" EXACT [GOC:sp] synonym: "DDX58/RIG-I binding" EXACT [GOC:sp] is_a: GO:0005102 ! signaling receptor binding created_by: rfoulger creation_date: 2012-01-19T02:14:20Z [Term] id: GO:0039553 name: suppression by virus of host chemokine activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813] synonym: "down-regulation by virus of host chemokine activity" EXACT [GOC:bf] synonym: "downregulation by virus of host chemokine activity" EXACT [GOC:bf] synonym: "inhibition by virus of host chemokine activity" NARROW [GOC:bf] synonym: "inhibition of host chemokines by virus" NARROW [UniProtKB-KW:KW-1086] synonym: "negative regulation by virus of host chemokine activity" EXACT [GOC:bf] xref: VZ:813 "Inhibition of host chemokines by virus" is_a: GO:0039518 ! suppression by virus of host cytokine activity created_by: rfoulger creation_date: 2012-02-28T01:29:55Z [Term] id: GO:0039554 name: suppression by virus of host MDA-5 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [UniProtKB-KW:KW-1089, VZ:603] synonym: "inhibition of host IFIH1/MDA5 by virus" RELATED [UniProtKB-KW:KW-1089] synonym: "Inhibition of host MDA5 by virus" EXACT [VZ:603] xref: VZ:603 "Inhibition of host MDA5 by virus" is_a: GO:0039509 ! suppression by virus of host pattern recognition receptor activity is_a: GO:0039539 ! suppression by virus of host MDA-5 signaling pathway created_by: rfoulger creation_date: 2012-03-09T03:03:49Z [Term] id: GO:0039555 name: obsolete suppression by virus of host MDA-5 activity via MDA-5 binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by interacting selectively and non-covalently with MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector." [PMID:19019954, VZ:603] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host MDA5 activity by MDA-5 binding" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-03-09T04:06:46Z [Term] id: GO:0039556 name: MDA-5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA." [PMID:19019954] synonym: "MDA5 binding" EXACT [GOC:bf] is_a: GO:0005102 ! signaling receptor binding created_by: rfoulger creation_date: 2012-03-09T04:12:33Z [Term] id: GO:0039557 name: suppression by virus of host IRF7 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [UniProtKB-KW:KW-1093, VZ:653] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition of host interferon regulatory factor-7 by virus" EXACT [VZ:653] synonym: "inhibition of host IRF7 by virus" EXACT [UniProtKB-KW:KW-1093] synonym: "suppression by virus of host interferon regulatory factor 7 activity" EXACT [PR:000002049] xref: VZ:653 "Inhibition of host IRF7 by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2012-03-09T04:17:46Z [Term] id: GO:0039558 name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity." [PMID:18635538, PMID:19694547, VZ:653] comment: The reason for obsoleting is that the term is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "promotion of IRF-7 SUMOylation" EXACT [PMID:19694547] synonym: "suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation" RELATED [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-03-09T04:27:57Z [Term] id: GO:0039559 name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome." [PMID:17301153, VZ:653] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "promotion by virus of proteosome-dependent IRF7 degradation" EXACT [VZ:653] is_obsolete: true created_by: rfoulger creation_date: 2012-03-09T04:38:58Z [Term] id: GO:0039560 name: suppression by virus of host IRF9 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [UniProtKB-KW:KW-1094, VZ:683] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition of host interferon regulatory factor-9 by virus" EXACT [GOC:bf] synonym: "inhibition of host IRF9 by virus" EXACT [UniProtKB-KW:KW-1094] synonym: "suppression by virus of host interferon regulatory factor 9 activity" EXACT [PR:000002051] xref: VZ:683 "Inhibition of host IRF9 by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2012-03-09T04:42:08Z [Term] id: GO:0039561 name: obsolete suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism." [PMID:19109390] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host IRF9 activity by nuclear localization of IRF9" RELATED [PMID:19109390] synonym: "suppression of interferon signaling by nuclear accumulation of IRF9" RELATED [PMID:19109390] is_obsolete: true created_by: rfoulger creation_date: 2012-03-09T04:53:44Z [Term] id: GO:0039562 name: suppression by virus of host STAT activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition by virus of host STAT activity" NARROW [GOC:bf] synonym: "suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade created_by: rfoulger creation_date: 2012-03-12T02:28:39Z [Term] id: GO:0039563 name: suppression by virus of host STAT1 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1105, VZ:282] comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. synonym: "inhibition by virus of host STAT1 activity" NARROW [GOC:bf] synonym: "Inhibition of host STAT1 by virus" NARROW [VZ:282] xref: VZ:282 "Inhibition of host STAT1 by virus" is_a: GO:0039562 ! suppression by virus of host STAT activity created_by: rfoulger creation_date: 2012-03-12T02:35:39Z [Term] id: GO:0039564 name: suppression by virus of host STAT2 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1106, VZ:257] synonym: "inhibition by virus of host STAT2 activity" NARROW [GOC:bf] synonym: "Inhibition of host STAT2 by virus" EXACT [VZ:257] xref: VZ:257 "Inhibition of host STAT2 by virus" is_a: GO:0039562 ! suppression by virus of host STAT activity created_by: rfoulger creation_date: 2012-03-12T02:52:34Z [Term] id: GO:0039565 name: obsolete suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome." [PMID:15280488, PMID:16227264, VZ:282] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "promotion by virus of proteosome-dependent STAT1 degradation" EXACT [] synonym: "suppression by virus of host STAT1 activity by positive promotion of STAT1 proteasome-mediated degradation" EXACT [GOC:bf] synonym: "targeting STAT1 for proteasome-mediated degradation" EXACT [VZ:282] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T02:57:36Z [Term] id: GO:0039566 name: obsolete suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1 namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation." [PMID:11238845, PMID:21362620, VZ:282] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host STAT1 activity by peptidyl-tyrosine dephosphorylation of STAT1" EXACT [GOC:bf] synonym: "viral tyrosine phosphatase activity involved in suppression of host STAT1" RELATED [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:08:32Z [Term] id: GO:0039567 name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668, PMID:16254375, PMID:17287281] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "cytoplasmic sequestration of STAT1" BROAD [PMID:14557668] synonym: "suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1" EXACT [PMID:14557668] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:24:36Z [Term] id: GO:0039568 name: obsolete suppression by virus of host STAT1 activity by inhibition of DNA binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus." [PMID:17287281] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition of DNA binding of STAT1" EXACT [PMID:17287281] synonym: "suppression by virus of host STAT1 activity by negative regulation of DNA binding" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:31:58Z [Term] id: GO:0039569 name: obsolete suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome." [PMID:11336548, PMID:17251292, PMID:19279106, VZ:257] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "promotion by virus of proteosome-dependent STAT2 degradation" EXACT [] synonym: "suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation" EXACT [GOC:bf] synonym: "targeting STAT2 for proteasome-mediated degradation" EXACT [VZ:257] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:43:44Z [Term] id: GO:0039570 name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "cytoplasmic sequestering of STAT2" EXACT [GOC:bf] synonym: "cytoplasmic sequestration of STAT2" EXACT [PMID:14557668] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:46:49Z [Term] id: GO:0039571 name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation." [PMID:12804771] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of tyrosine phosphorylation of STAT1" RELATED [PMID:12804771] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:50:38Z [Term] id: GO:0039572 name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation." [PMID:12804771] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of tyrosine phosphorylation of STAT2" EXACT [PMID:12804771] is_obsolete: true created_by: rfoulger creation_date: 2012-03-12T04:53:50Z [Term] id: GO:0039573 name: suppression by virus of host complement activation namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase." [PMID:21191012, PMID:7745740, UniProtKB-KW:KW-1087, VZ:811] synonym: "inhibition of host complement activation by virus" EXACT [GOC:bf] synonym: "inhibition of host complement cascade by virus" EXACT [GOC:bf] synonym: "inhibition of host complement factors by virus" BROAD [UniProtKB-KW:KW-1087] xref: VZ:811 "Inhibition of host complement factors by virus" is_a: GO:0030683 ! mitigation of host immune response by virus is_a: GO:0045916 ! negative regulation of complement activation is_a: GO:0075528 ! modulation by virus of host immune response intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0006956 ! complement activation created_by: rfoulger [Term] id: GO:0039574 name: suppression by virus of host TYK2 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits." [UniProtKB-KW:KW-1112, VZ:720] synonym: "suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" EXACT [PR:000016874] xref: VZ:720 "Inhibition of host TYK2 by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039512 ! suppression by virus of host protein tyrosine kinase activity created_by: rfoulger [Term] id: GO:0039575 name: obsolete suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2." [PMID:10523853, PMID:16987978, PMID:19254804] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "inhibition by virus of host TYK2 activation" BROAD [GOC:bf, PMID:19254804] synonym: "inhibition by virus of host TYK2 phosphorylation" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger [Term] id: GO:0039576 name: suppression by virus of host JAK1 activity namespace: biological_process alt_id: GO:0039515 def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway." [UniProtKB-KW:KW-1096, VZ:784] synonym: "inhibition of host JAK activity by virus" NARROW [GOC:bf] synonym: "negative regulation by virus of host JAK" EXACT [GOC:bf] synonym: "negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] synonym: "suppression by virus of host janus kinase 1 activity" EXACT [PR:000009196] synonym: "suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW [] synonym: "viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] xref: VZ:784 "Inhibition of host JAK1 by virus" is_a: GO:0039512 ! suppression by virus of host protein tyrosine kinase activity is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade created_by: rfoulger [Term] id: GO:0039577 name: obsolete suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1." [PMID:12620806] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. is_obsolete: true created_by: rfoulger [Term] id: GO:0039578 name: obsolete suppression by virus of host JAK1 activity via JAK1 binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive." [PMID:9448289] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. is_obsolete: true created_by: rfoulger [Term] id: GO:0039579 name: suppression by virus of host ISG15 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives." [PMID:11157743, PMID:18604270, UniProtKB-KW:KW-1095, VZ:723] xref: VZ:723 "Inhibition of host ISG15 by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039507 ! suppression by virus of host molecular function created_by: rfoulger [Term] id: GO:0039580 name: suppression by virus of host PKR activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR." [PMID:15207627, UniProtKB-KW:KW-1102, VZ:554] synonym: "suppression by virus of host EIF2AK2 activity" EXACT [PR:000006959, UniProtKB-KW:KW-1102] xref: VZ:554 "Inhibition of host PKR by virus" is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039584 ! suppression by virus of host protein kinase activity created_by: rfoulger [Term] id: GO:0039581 name: obsolete suppression by virus of host PKR activity via double-stranded RNA binding namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding." [PMID:7514679] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host PKR activity by binding to dsRNA" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger [Term] id: GO:0039582 name: obsolete suppression by virus of host PKR activity by positive regulation of PKR nuclear localization namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha)." [PMID:16987971] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "suppression by virus of host PKR activity by nuclear sequestration of PKR" EXACT [GOC:bf] synonym: "suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus" EXACT [GOC:bf] synonym: "suppression by virus of host PKR activity by sequestering of PKR in nucleus" EXACT [PMID:16987971] is_obsolete: true created_by: rfoulger [Term] id: GO:0039583 name: obsolete suppression by virus of host PKR activity by positive regulation of PKR catabolic process namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes." [PMID:19751406] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "downregulation of PKR by degradation through proteosome" EXACT [PMID:19751406] synonym: "promotion by virus of proteosome-dependent PKR degradation" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-05-02T02:49:30Z [Term] id: GO:0039584 name: suppression by virus of host protein kinase activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." [GOC:bf] is_a: GO:0039513 ! suppression by virus of host catalytic activity is_a: GO:0039613 ! suppression by virus of host protein phosphorylation created_by: rfoulger creation_date: 2012-05-02T03:04:55Z [Term] id: GO:0039585 name: PKR signal transduction namespace: biological_process def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:9843495, VZ:1576] synonym: "PKR signaling pathway" EXACT [PMID:22102852] synonym: "signaling through PKR" EXACT [GOC:bf] is_a: GO:0035556 ! intracellular signal transduction created_by: rfoulger creation_date: 2012-05-02T04:15:10Z [Term] id: GO:0039586 name: modulation by virus of host PP1 activity namespace: biological_process def: "The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response." [UniProtKB-KW:KW-1126, VZ:803] synonym: "modulation of host PP1 activity by virus" EXACT [UniProtKB-KW:KW-1126] synonym: "regulation by virus of host PP1 activity" EXACT [GOC:bf] xref: VZ:803 "Modulation of host PP1 activity by virus" is_a: GO:0039517 ! modulation by virus of host protein serine/threonine phosphatase activity created_by: rfoulger creation_date: 2012-05-04T02:11:05Z [Term] id: GO:0039587 name: suppression by virus of host tetherin activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439, UniProtKB-KW:KW-1084, VZ:665] synonym: "inhibition of host BST2/Tetherin by virus" EXACT [UniProtKB-KW:KW-1084] synonym: "suppression by virus of host BST-2 activity" EXACT [PMID:22493439] xref: VZ:665 "Inhibition of host tetherin by virus" is_a: GO:0039506 ! modulation by virus of host molecular function created_by: rfoulger creation_date: 2012-05-04T02:33:29Z [Term] id: GO:0039588 name: suppression by virus of host antigen processing and presentation namespace: biological_process def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex." [UniProtKB-KW:KW-1117, VZ:815] synonym: "inhibition of host proteasome antigen processing by virus" EXACT [UniProtKB-KW:KW-1117] xref: VZ:815 "Inhibition of host proteasome antigen processing by virus" is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0030683 ! mitigation of host immune response by virus is_a: GO:0075528 ! modulation by virus of host immune response intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation created_by: rfoulger creation_date: 2012-05-04T04:34:52Z [Term] id: GO:0039589 name: obsolete suppression by virus of host TAP complex namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817] comment: This term was obsoleted because this type of process is now represented by the actual function inhibited. synonym: "inhibition of host TAP by virus" EXACT [UniProtKB-KW:KW-1107] xref: VZ:817 "Inhibition of host TAP by virus" is_obsolete: true consider: GO:0039588 created_by: rfoulger creation_date: 2012-06-22T14:42:06Z [Term] id: GO:0039591 name: suppression by virus of host tapasin activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host tapasin (TAP binding protein/TAPBP) activity. Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [UniProtKB-KW:KW-1108, VZ:818] comment: Consider also annotating to 'tapasin binding ; GO:0046980'. synonym: "inhibition of host tapasin by virus" EXACT [UniProtKB-KW:KW-1108] synonym: "inhibition of host TAPBP by virus" EXACT [UniProtKB-KW:KW-1108] synonym: "suppression by virus of host TAP binding protein" EXACT [HGNC:11566] xref: VZ:818 "Inhibition of host tapasin by virus" is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0046776 ! suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I created_by: rfoulger creation_date: 2012-06-25T01:27:48Z [Term] id: GO:0039592 name: suppression by virus of G2/M transition of host mitotic cell cycle namespace: biological_process def: "Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle." [UniProtKB-KW:KW-1079, VZ:876] synonym: "host G2/M cell cycle arrest by virus" EXACT [UniProtKB-KW:KW-1079] xref: VZ:876 "Host G2/M cell cycle arrest by virus" is_a: GO:0060153 ! modulation by virus of host cell cycle created_by: rfoulger creation_date: 2012-06-25T02:07:18Z [Term] id: GO:0039593 name: suppression by virus of host exit from mitosis namespace: biological_process def: "Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [UniProtKB-KW:KW-1098, VZ:877] synonym: "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877] xref: VZ:877 "Inhibition of host mitotic exit by virus" is_a: GO:0060153 ! modulation by virus of host cell cycle created_by: rfoulger creation_date: 2012-06-25T02:21:20Z [Term] id: GO:0039594 name: endoribonuclease activity involved in viral induction of host mRNA catabolic process namespace: molecular_function def: "Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA." [GOC:bf, PMID:22046136] comment: GO:0039594 can be used to annotate a host or viral endoribonuclease activity that cleaves host mRNA in response to a viral infection. is_a: GO:0004521 ! endoribonuclease activity relationship: part_of GO:0039599 ! cleavage by virus of host mRNA relationship: part_of GO:0039600 ! induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process created_by: rfoulger creation_date: 2012-07-05T11:21:26Z [Term] id: GO:0039595 name: induction by virus of catabolism of host mRNA namespace: biological_process def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA)." [GOC:bf, UniProtKB-KW:KW-1132] synonym: "induction by virus of host mRNA catabolic process" EXACT [GOC:bf] synonym: "induction of host mRNA decay" EXACT [VZ:901] synonym: "promotion of host mRNA degradation" EXACT [] synonym: "viral induction of host mRNA decay" EXACT [GOC:bf] synonym: "virus-mediated mRNA decay" EXACT [VZ:901] xref: VZ:901 "Virus-mediated host mRNA decay" is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0061014 ! positive regulation of mRNA catabolic process created_by: rfoulger creation_date: 2012-07-04T03:14:04Z [Term] id: GO:0039596 name: modulation by virus of host protein dephosphorylation namespace: biological_process def: "Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein." [GOC:bf] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0035304 ! regulation of protein dephosphorylation created_by: rfoulger creation_date: 2012-07-19T11:46:23Z [Term] id: GO:0039597 name: induction by virus of host endoribonuclease activity namespace: biological_process def: "Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity." [PMID:22174690] comment: GO:0039597 should be used to annotate viral proteins which utilize a host RNase to induce endonucleolytic cleavage of mRNAs (e.g. the NSP1 protein of SARS coronavirus). For viral proteins that have endoribonuclease activity themselves, consider instead annotating to: 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'. synonym: "viral induction of host RNAse activity" EXACT [GOC:bf] is_a: GO:0039600 ! induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process is_a: GO:0039712 ! induction by virus of host catalytic activity created_by: rfoulger creation_date: 2012-07-04T04:36:49Z [Term] id: GO:0039598 name: obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process namespace: biological_process def: "OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:sp] comment: This term was made obsolete because it is unclear what role the viral protein is playing in this process. and there is insufficient evidence to use this term for annotation. synonym: "induction by virus of host nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] synonym: "induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process" EXACT [] synonym: "virus-mediated host mRNA decay by hyperadenylation" NARROW [GOC:sp] is_obsolete: true created_by: rfoulger creation_date: 2012-07-04T04:44:16Z [Term] id: GO:0039599 name: cleavage by virus of host mRNA namespace: biological_process def: "Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease." [PMID:22046136] synonym: "host mRNA cleavage by viral endoribonuclease" EXACT [GOC:bf] synonym: "viral endoribonuclease activity involved in degradation of host mRNA" RELATED [GOC:bf] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0044033 ! multi-organism metabolic process created_by: rfoulger creation_date: 2012-07-04T05:09:08Z [Term] id: GO:0039600 name: induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process namespace: biological_process def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends." [GOC:bf, PMID:22174690] comment: Some viruses utilize a host RNase to induce endonucleolytic cleavage of template mRNAs (e.g. the NSP1 protein of SARS coronavirus); for these consider instead annotating to the child term 'induction by virus of host endoribonuclease activity ; GO:0039597'. Other viral proteins act as endonucleases themselves to cleave mRNA and then rely on the host degradation machinery to clear the resulting fragments (e.g. gamma herpesvirus SOX protein); for these cases consider instead annotating to the child term 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'. synonym: "induction by virus of host endonucleolytic cleavage-dependent mRNA decay" EXACT [GOC:bf] synonym: "induction by virus of host nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [GOC:bf] is_a: GO:0039595 ! induction by virus of catabolism of host mRNA created_by: rfoulger creation_date: 2012-07-04T05:23:43Z [Term] id: GO:0039602 name: suppression by virus of host transcription initiation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0039601 def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [UniProtKB-KW:KW-1111, VZ:904] synonym: "inhibition of host transcription initiation by virus" EXACT [GOC:bf] synonym: "suppression by virus of host DNA-dependent transcription, initiation" EXACT [] xref: VZ:904 "Inhibition of host transcription initiation by virus" is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2012-07-05T03:29:34Z [Term] id: GO:0039603 name: obsolete TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter namespace: molecular_function def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:11968006] comment: The reason for obsoletion is that the term is too specific, and the paper referenced in the term should instead be annotated to GO:0039602 suppression by virus of host transcription initiation from RNA polymerase II promoter. See https://github.com/geneontology/go-ontology/issues/14640 is_obsolete: true created_by: rfoulger creation_date: 2012-07-05T04:00:15Z [Term] id: GO:0039604 name: suppression by virus of host translation namespace: biological_process def: "Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA." [UniProtKB-KW:KW-1193, VZ:1579] synonym: "host translation shutoff by virus" EXACT [UniProtKB-KW:KW-1193, VZ:1579] synonym: "viral inhibition of cellular protein synthesis" EXACT [VZ:1579] synonym: "viral shutoff of host protein synthesis" EXACT [PMID:8643618] xref: VZ:1579 "Translation shutoff" is_a: GO:0019057 ! modulation by virus of host translation is_a: GO:0039657 ! suppression by virus of host gene expression created_by: rfoulger creation_date: 2012-07-05T04:25:22Z [Term] id: GO:0039605 name: obsolete TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter namespace: molecular_function def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:18768974] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. is_obsolete: true created_by: rfoulger creation_date: 2012-07-05T04:16:45Z [Term] id: GO:0039606 name: suppression by virus of host translation initiation namespace: biological_process def: "Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein." [GOC:bf] is_a: GO:0039604 ! suppression by virus of host translation created_by: rfoulger creation_date: 2012-07-05T04:44:10Z [Term] id: GO:0039607 name: obsolete proteolysis by virus of host translation initiation factor namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds." [PMID:18572216] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. synonym: "cleavage of host translation initiation factor by viral protease" EXACT [GOC:bf] synonym: "cleavage of host translation initiation factor by virus" RELATED [GOC:sp] synonym: "proteolytic cleavage by virus of host translation initiation factor" EXACT [GOC:bf] synonym: "suppression by virus of host translation initiation factor activity by proteolysis" EXACT [GOC:bf] is_obsolete: true created_by: rfoulger creation_date: 2012-07-05T04:46:21Z [Term] id: GO:0039608 name: obsolete suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation namespace: biological_process def: "OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein." [PMID:12239292, PMID:8643618] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. is_obsolete: true created_by: rfoulger creation_date: 2012-07-06T10:30:57Z [Term] id: GO:0039611 name: suppression by virus of host translation initiation factor activity namespace: biological_process def: "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor." [GOC:bf, UniProtKB-KW:KW-1075] synonym: "inactivation of eIF2 activity" NARROW [PMID:12239292] synonym: "inhibition of activity of host translation initiation factor" EXACT [PMID:12239292] synonym: "Inhibition of host translation factors by virus" BROAD [UniProtKB-KW:KW-1075] synonym: "suppression by virus of host EIF-4E activity" EXACT [GOC:bf] is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039606 ! suppression by virus of host translation initiation created_by: rfoulger creation_date: 2012-07-06T10:27:16Z [Term] id: GO:0039612 name: modulation by virus of host protein phosphorylation namespace: biological_process def: "Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0019054 ! modulation by virus of host cellular process created_by: rfoulger creation_date: 2012-07-06T11:13:59Z [Term] id: GO:0039613 name: suppression by virus of host protein phosphorylation namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] synonym: "viral inhibition of host protein phosphorylation" EXACT [GOC:bf] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0039612 ! modulation by virus of host protein phosphorylation created_by: rfoulger creation_date: 2012-07-06T11:15:56Z [Term] id: GO:0039614 name: induction by virus of host protein phosphorylation namespace: biological_process def: "Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0039612 ! modulation by virus of host protein phosphorylation created_by: rfoulger creation_date: 2012-07-06T11:15:56Z [Term] id: GO:0039615 name: T=1 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [UniProtKB-KW:KW-1140, VZ:1057] xref: VZ:1057 "T=1 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T01:46:17Z [Term] id: GO:0039616 name: T=2 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [UniProtKB-KW:KW-1141, VZ:838] comment: The T=2 symmetry is an non-official appellation; strictly speaking the capsid has a T=1 symmetry with each unit composed of a homodimer. xref: VZ:838 "T=2 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:01:55Z [Term] id: GO:0039617 name: T=3 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1142, VZ:806] xref: VZ:806 "T=3 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:07:40Z [Term] id: GO:0039618 name: T=pseudo3 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1143, VZ:809] comment: T=pseudo3 capsids are not T=3 symmetry as described by Caspar and Klug (PMID:14019094) because the basic unit is composed of three different proteins. Since the three subunits are morphologically very similar, the structure is therefore a pseudo T=3. xref: VZ:809 "T=pseudo3 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:10:02Z [Term] id: GO:0039619 name: T=4 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [UniProtKB-KW:KW-1144, VZ:808] xref: VZ:808 "T=4 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:15:14Z [Term] id: GO:0039620 name: T=7 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [UniProtKB-KW:KW-1145, VZ:804] comment: Spherical viruses with T numbers greater than or equal to 7 are skewed. They are therefore described as either right-handed (dextro) or left-handed (laevo). xref: VZ:804 "T=7 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:16:40Z [Term] id: GO:0039621 name: T=13 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [UniProtKB-KW:KW-1146, VZ:260] xref: VZ:260 "T=13 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:18:59Z [Term] id: GO:0039622 name: T=16 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [UniProtKB-KW:KW-1147, VZ:807] xref: VZ:807 "T=16 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:20:23Z [Term] id: GO:0039623 name: T=25 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [UniProtKB-KW:KW-1148, VZ:810] xref: VZ:810 "T=25 icosahedral capsid protein" is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T02:21:43Z [Term] id: GO:0039624 name: viral outer capsid namespace: cellular_component def: "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1152] synonym: "outer capsid" EXACT [GOC:bf] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T04:03:16Z [Term] id: GO:0039625 name: viral inner capsid namespace: cellular_component def: "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1153] synonym: "inner capsid" EXACT [GOC:bf] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T04:05:35Z [Term] id: GO:0039626 name: viral intermediate capsid namespace: cellular_component def: "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions." [UniProtKB-KW:KW-1154] synonym: "intermediate capsid" EXACT [GOC:bf] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-07-18T04:06:25Z [Term] id: GO:0039627 name: T=147 icosahedral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins." [GOC:plm, UniProtKB-KW:KW-0167] is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-08-03T16:18:49Z [Term] id: GO:0039628 name: T=169 icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1150] synonym: "T=169 icosahedral capsid" EXACT [GOC:bf] is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-08-03T16:27:55Z [Term] id: GO:0039629 name: T=219 icosahedral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1151] is_a: GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2012-08-03T16:29:00Z [Term] id: GO:0039630 name: RNA translocase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule." [GOC:bm, PMID:22713318] comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. is_a: GO:0008186 ! RNA-dependent ATPase activity created_by: rfoulger creation_date: 2012-08-06T13:24:51Z [Term] id: GO:0039631 name: DNA translocase activity involved in viral DNA genome packaging namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid." [GOC:bm, PMID:17501915] synonym: "viral DNA packaging activity" RELATED [GOC:bm] synonym: "viral DNA packaging motor activity" RELATED [PMID:17501915] is_a: GO:0015616 ! DNA translocase activity intersection_of: GO:0015616 ! DNA translocase activity intersection_of: part_of GO:0019073 ! viral DNA genome packaging relationship: part_of GO:0019073 ! viral DNA genome packaging created_by: rfoulger creation_date: 2012-08-07T11:17:07Z [Term] id: GO:0039632 name: RNA translocase activity involved in viral RNA genome packaging namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid." [GOC:bm, PMID:22297533] synonym: "RNA packaging ATPase activity" EXACT [PMID:22297533] synonym: "viral RNA packaging activity" RELATED [GOC:bm] is_a: GO:0039630 ! RNA translocase activity intersection_of: GO:0039630 ! RNA translocase activity intersection_of: part_of GO:0019074 ! viral RNA genome packaging relationship: part_of GO:0019074 ! viral RNA genome packaging created_by: rfoulger creation_date: 2012-08-07T11:20:53Z [Term] id: GO:0039633 name: killing by virus of host cell namespace: biological_process def: "Any process mediated by a virus that results in the death of a cell in the host organism." [GOC:bf, GOC:bm, GOC:jl] synonym: "killing by phage of host cells" NARROW [GOC:bm] synonym: "killing by virus of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0019048 ! modulation by virus of host morphology or physiology created_by: rfoulger creation_date: 2012-08-10T14:44:40Z [Term] id: GO:0039634 name: killing by virus of host cell during superinfection exclusion namespace: biological_process def: "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bf, GOC:bm, GOC:jl, PMID:22398285] synonym: "killing by virus of host cells during superinfection exclusion" EXACT [] synonym: "killing by virus of host cells involved in superinfection exclusion" EXACT [GOC:bf] synonym: "Rex exclusion" NARROW [] is_a: GO:0009615 ! response to virus is_a: GO:0039633 ! killing by virus of host cell created_by: rfoulger creation_date: 2012-08-10T14:46:03Z [Term] id: GO:0039635 name: suppression by virus of host peptidoglycan biosynthetic process namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, GOC:jl] synonym: "viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf] is_a: GO:0039636 ! suppression by virus of host cell wall biogenesis created_by: rfoulger creation_date: 2012-08-10T14:58:12Z [Term] id: GO:0039636 name: suppression by virus of host cell wall biogenesis namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts." [GOC:bf, GOC:bm, GOC:jl] is_a: GO:0019054 ! modulation by virus of host cellular process created_by: rfoulger creation_date: 2012-08-10T15:04:12Z [Term] id: GO:0039637 name: catabolism by virus of host DNA namespace: biological_process def: "The breakdown of host DNA, deoxyribonucleic acid, by a virus." [GOC:bf, GOC:bm, GOC:jl] is_a: GO:0019048 ! modulation by virus of host morphology or physiology created_by: rfoulger creation_date: 2012-08-10T15:59:22Z [Term] id: GO:0039638 name: lipopolysaccharide-mediated virion attachment to host cell namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface." [GOC:bf, GOC:bm, PMID:12837775] synonym: "lipopolysaccharide binding involved in viral attachment to host cell" EXACT [GOC:bf, GOC:bm] synonym: "LPS binding involved in viral attachment to host cell" EXACT [GOC:bf] synonym: "virion attachment, binding to host lipopolysaccharide" EXACT [GOC:bf, GOC:jl] is_a: GO:0019062 ! virion attachment to host cell relationship: has_part GO:0001530 ! lipopolysaccharide binding created_by: rfoulger creation_date: 2012-08-17T10:13:06Z [Term] id: GO:0039639 name: suppression by virus of host cell lysis in response to superinfection namespace: biological_process def: "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373] synonym: "lysis inhibition" BROAD [GOC:bm, PMID:22389108] synonym: "suppression by virus of host cell lysis in response to superinfecting virus" EXACT [GOC:bf] is_a: GO:0001899 ! negative regulation of cytolysis by symbiont of host cells is_a: GO:0098586 ! cellular response to virus created_by: rfoulger creation_date: 2012-08-17T10:42:27Z [Term] id: GO:0039640 name: cytolysis by virus via suppression of host peptidoglycan biosynthetic process namespace: biological_process def: "The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm] is_a: GO:0044659 ! cytolysis by virus of host cell relationship: has_part GO:0039635 ! suppression by virus of host peptidoglycan biosynthetic process created_by: rfoulger creation_date: 2012-08-17T10:54:55Z [Term] id: GO:0039641 name: viral inner membrane namespace: cellular_component def: "The lipid bilayer of a virion contained inside the protein capsid." [GOC:bm, PMID:15331712] synonym: "virion inner membrane" EXACT [GOC:bf, GOC:bm, GOC:jl] is_a: GO:0036338 ! viral membrane created_by: rfoulger creation_date: 2012-09-07T13:29:48Z [Term] id: GO:0039642 name: virion nucleoid namespace: cellular_component def: "The region of a virion in which the nucleic acid is confined." [GOC:bm, PMID:14291596] is_a: GO:0009295 ! nucleoid is_a: GO:0044423 ! virion part intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0019012 ! virion created_by: rfoulger creation_date: 2012-09-07T14:14:52Z [Term] id: GO:0039643 name: host cell viral nucleoid namespace: cellular_component def: "The region of a host cell that contains the viral genome." [GOC:bf, GOC:bm, GOC:jl] comment: To annotate the region of the complete virus particle in which the viral genome is contained, instead use 'virion nucleoid ; GO:0039642'. is_a: GO:0033646 ! host intracellular part created_by: rfoulger creation_date: 2012-09-07T15:41:18Z [Term] id: GO:0039644 name: suppression by virus of host NF-kappaB transcription factor activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity." [UniProtKB-KW:KW-1100, VZ:695] synonym: "inhibition of host NF-kappa-B by virus" EXACT [UniProtKB-KW:KW-1100, VZ:695] xref: VZ:695 "Inhibition of host NF-kappa-B by virus" is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039653 ! suppression by virus of host transcription created_by: rfoulger creation_date: 2012-10-09T15:04:27Z [Term] id: GO:0039645 name: modulation by virus of host G1/S transition checkpoint namespace: biological_process def: "Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint." [UniProtKB-KW:KW-1078] synonym: "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1078, VZ:880] xref: VZ:880 "G1/S host cell cycle checkpoint dysregulation by virus" is_a: GO:0060153 ! modulation by virus of host cell cycle created_by: rfoulger creation_date: 2012-10-09T15:08:57Z [Term] id: GO:0039646 name: modulation by virus of host G0/G1 transition checkpoint namespace: biological_process def: "Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint." [UniProtKB-KW:KW-1077] synonym: "G0/G1 host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1077, VZ:881] xref: VZ:881 "G0/G1 host cell cycle checkpoint dysregulation by virus" is_a: GO:0060153 ! modulation by virus of host cell cycle created_by: rfoulger creation_date: 2012-10-09T15:11:22Z [Term] id: GO:0039647 name: suppression by virus of host poly(A)-binding protein activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation." [UniProtKB-KW:KW-1101] synonym: "inhibition of host poly(A)-binding protein by virus" EXACT [UniProtKB-KW:KW-1101] synonym: "suppression by virus of host PABP activity" EXACT [Wikipedia:Poly(A)-binding_protein] is_a: GO:0039507 ! suppression by virus of host molecular function is_a: GO:0039604 ! suppression by virus of host translation created_by: rfoulger creation_date: 2012-10-09T15:14:07Z [Term] id: GO:0039648 name: modulation by virus of host protein ubiquitination namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein." [UniProtKB-KW:KW-1130] synonym: "modulation of host ubiquitin pathway by virus" RELATED [UniProtKB-KW:KW-1130] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0031396 ! regulation of protein ubiquitination intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0016567 ! protein ubiquitination created_by: rfoulger creation_date: 2012-10-09T15:20:47Z [Term] id: GO:0039649 name: modulation by virus of host ubiquitin-protein ligase activity namespace: biological_process def: "The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [UniProtKB-KW:KW-1123] synonym: "modulation of host E3 ubiquitin ligases by virus" NARROW [UniProtKB-KW:KW-1123] is_a: GO:0039516 ! modulation by virus of host catalytic activity is_a: GO:0039648 ! modulation by virus of host protein ubiquitination is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0061630 ! ubiquitin protein ligase activity created_by: rfoulger creation_date: 2012-10-09T15:26:56Z [Term] id: GO:0039650 name: suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process." [UniProtKB-KW:KW-1085, VZ:912] synonym: "inhibition of host caspases by virus" NARROW [UniProtKB-KW:KW-1085, VZ:912] is_a: GO:0019050 ! suppression by virus of host apoptotic process is_a: GO:0039513 ! suppression by virus of host catalytic activity created_by: rfoulger creation_date: 2012-10-09T15:30:48Z [Term] id: GO:0039651 name: induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process." [GOC:mtg_apoptosis, UniProtKB-KW:KW-1073] synonym: "activation of host caspases by virus" NARROW [UniProtKB-KW:KW-1073] synonym: "induction by virus of host caspase activity" NARROW [GOC:bf, GOC:jl] is_a: GO:0019051 ! induction by virus of host apoptotic process is_a: GO:0039712 ! induction by virus of host catalytic activity created_by: rfoulger creation_date: 2012-10-09T15:44:29Z [Term] id: GO:0039652 name: activation by virus of host NF-kappaB transcription factor activity namespace: biological_process def: "Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB." [UniProtKB-KW:KW-1074] synonym: "activation of host NF-kappa-B by virus" EXACT [UniProtKB-KW:KW-1074] xref: VZ:841 "Activation of host NF-kappa-B by virus" is_a: GO:0019056 ! modulation by virus of host transcription is_a: GO:0039506 ! modulation by virus of host molecular function created_by: rfoulger creation_date: 2012-10-11T16:04:31Z [Term] id: GO:0039653 name: suppression by virus of host transcription namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors." [UniProtKB-KW:KW-1191, VZ:1577] synonym: "host transcription shutoff by virus" NARROW [UniProtKB-KW:KW-1191, VZ:1577] synonym: "suppression by virus of host DNA-dependent transcription" EXACT [GOC:bf] xref: VZ:1577 "Host transcription shutoff by virus" is_a: GO:0019056 ! modulation by virus of host transcription is_a: GO:0039657 ! suppression by virus of host gene expression created_by: rfoulger creation_date: 2012-10-11T16:11:17Z [Term] id: GO:0039654 name: fusion of virus membrane with host endosome membrane namespace: biological_process alt_id: GO:0075501 alt_id: GO:0075517 def: "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell." [GOC:bf, UniProtKB-KW:KW-1170, VZ:992] synonym: "fusion of virus membrane with host endosomal membrane" EXACT [UniProtKB-KW:KW-1170, VZ:992] synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [GOC:bf, GOC:jl] synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [] synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [] synonym: "viral entry into host cell via endocytosis followed by membrane fusion with host endosome" RELATED [GOC:bf, GOC:jl] synonym: "viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane" NARROW [] synonym: "viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane" NARROW [] xref: VZ:992 "Fusion of virus membrane with host endosomal membrane" is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell created_by: rfoulger creation_date: 2013-06-20T14:24:05Z [Term] id: GO:0039655 name: obsolete transport of virus in host, cell to cell via plasmodesmata namespace: biological_process def: "OBSOLETE. The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell." [UniProtKB-KW:KW-0916, VZ:1018] synonym: "spread of virus in host, cell to cell via plasmodesmata" RELATED [GOC:bf, GOC:jl] synonym: "viral movement protein" RELATED [VZ:1018] xref: VZ:1018 "Viral movement protein" is_obsolete: true created_by: rfoulger creation_date: 2013-06-20T14:47:50Z [Term] id: GO:0039656 name: modulation by virus of host gene expression namespace: biological_process def: "The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:bf] synonym: "regulation by virus of host gene expression" RELATED [GOC:bf] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: regulates GO:0010467 ! gene expression created_by: rfoulger creation_date: 2013-06-20T15:28:26Z [Term] id: GO:0039657 name: suppression by virus of host gene expression namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [UniProtKB-KW:KW-1190, VZ:1582] synonym: "host gene expression shutoff by virus" EXACT [UniProtKB-KW:KW-1190, VZ:1582] xref: VZ:1582 "Host gene expression shutoff by virus" is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0039656 ! modulation by virus of host gene expression created_by: rfoulger creation_date: 2013-06-20T15:29:55Z [Term] id: GO:0039658 name: TBK1-IKKE-DDX3 complex namespace: cellular_component def: "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3." [PMID:18636090, VZ:719] synonym: "TBK1-IKBKE-DDX3 complex" EXACT [VZ:719] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2013-07-03T16:59:27Z [Term] id: GO:0039659 name: obsolete suppression by virus of host TBK1-IKBKE-DDX3 complex activity namespace: biological_process def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex." [VZ:719] comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. See also: suppression by virus of host TBK1 activity; GO:0039723, and suppression by virus of host IKBKE activity; GO:0039724. synonym: "inhibition of host TBK1-IKBKE-DDX3 complex by virus" EXACT [VZ:719] synonym: "suppression by virus of host TBK1-IKKE-DDX3 complex activity" EXACT [] xref: VZ:719 "Inhibition of host TBK1-IKBKE-DDX3 complex by virus" is_obsolete: true created_by: rfoulger creation_date: 2013-07-15T15:10:39Z [Term] id: GO:0039660 name: structural constituent of virion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a virion." [GOC:bf, GOC:jl] synonym: "viral matrix protein" NARROW [UniProtKB-KW:KW-0468] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0019012 ! virion relationship: occurs_in GO:0019012 ! virion created_by: rfoulger creation_date: 2013-07-22T16:43:41Z [Term] id: GO:0039661 name: host organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell." [GOC:bf, GOC:ch] is_a: GO:0044384 ! host outer membrane created_by: rfoulger creation_date: 2013-08-25T10:44:43Z [Term] id: GO:0039662 name: host cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell." [GOC:bf, GOC:ch] synonym: "host cell envelope outer membrane" EXACT [GOC:bf, GOC:ch] synonym: "outer membrane of host cell" EXACT [GOC:bf, GOC:ch] is_a: GO:0044384 ! host outer membrane relationship: part_of GO:0044230 ! host cell envelope created_by: rfoulger creation_date: 2013-08-25T10:48:41Z [Term] id: GO:0039663 name: membrane fusion involved in viral entry into host cell namespace: biological_process def: "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168] synonym: "fusion of virus membrane with host membrane" RELATED [UniProtKB-KW:KW-1168] synonym: "fusion of virus membrane with host membrane during viral entry" RELATED [UniProtKB-KW:KW-1168] synonym: "viral entry into host cell via membrane fusion" RELATED [GOC:bf, GOC:jl] is_a: GO:0044800 ! multi-organism membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: part_of GO:0046718 ! viral entry into host cell relationship: part_of GO:0046718 ! viral entry into host cell created_by: rfoulger creation_date: 2013-08-29T10:15:11Z [Term] id: GO:0039664 name: lysis of host organelle involved in viral entry into host cell namespace: biological_process def: "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984] synonym: "viral entry into host cell via endosome membrane lysis" NARROW [VZ:984] synonym: "viral entry into host cell via lysis of host organelle membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral membrane-lytic protein" RELATED [UniProtKB-KW:KW-1174] synonym: "viral penetration via lysis of host organellar membrane" EXACT [UniProtKB-KW:KW-984] xref: VZ:984 "Viral penetration via lysis of host organellar membrane" is_a: GO:0016032 ! viral process relationship: has_part GO:0044662 ! disruption by virus of host cell membrane relationship: part_of GO:0046718 ! viral entry into host cell created_by: rfoulger creation_date: 2013-08-29T11:30:18Z [Term] id: GO:0039665 name: permeabilization of host organelle membrane involved in viral entry into host cell namespace: biological_process def: "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985] synonym: "viral entry into host cell via permeabilization of host organelle membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral membrane-penetration protein" RELATED [UniProtKB-KW:KW-1173] synonym: "viral penetration via host endosomal membrane disruption by virus" EXACT [UniProtKB-KW:KW-1173] synonym: "viral penetration via perforation of host organellar membrane by virus" EXACT [UniProtKB-KW:KW-1173] synonym: "viral penetration via permeabilization of host organellar membrane" EXACT [UniProtKB-KW:KW-1173, VZ:985] xref: VZ:985 "Viral penetration via permeabilization of host organellar membrane" is_a: GO:0016032 ! viral process relationship: part_of GO:0140267 ! viral entry via permeabilization of host membrane created_by: rfoulger creation_date: 2013-08-29T11:57:21Z [Term] id: GO:0039666 name: virion attachment to host cell pilus namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side." [UniProtKB-KW:KW-1175, VZ:981] synonym: "pilus-adsorption protein" EXACT [PMID:16298408] synonym: "pilus-mediated viral adsorption onto host cell" RELATED [UniProtKB-KW:KW-1175, VZ:981] synonym: "pilus-mediated viral attachment to host cell" RELATED [GOC:bf, GOC:jl] synonym: "viral attachment to host cell pilus" RELATED [GOC:bf, GOC:jl] xref: VZ:981 "Pilus-mediated viral adsorption onto host cell" is_a: GO:0019062 ! virion attachment to host cell created_by: rfoulger creation_date: 2013-08-29T13:31:10Z [Term] id: GO:0039667 name: viral entry into host cell via pilus retraction namespace: biological_process def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus." [GOC:bf, GOC:jl, VZ:981] comment: This method of entry into the cell differs between viruses; filamentous bacteriophages have rod-shaped virions which attach to the tip of the pilus; after retraction of the pilus with the virion attached, the genome can enter the host cell through the pilus basal pore. For icosahedral viruses, retraction of the pilus brings the virus in contact with the cell membrane and the genome can enter the cell via membrane fusion or genome injection. In GO, viral entry begins after viral attachment; for pilus-attachment proteins see instead: viral attachment to host cell pilus ; GO:0039666. is_a: GO:0046718 ! viral entry into host cell relationship: has_part GO:0043108 ! pilus retraction relationship: has_part GO:0046794 ! transport of virus created_by: rfoulger creation_date: 2013-09-04T14:32:19Z [Term] id: GO:0039668 name: viral entry into host cell via pilus basal pore namespace: biological_process def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way." [GOC:bf, GOC:jl] synonym: "filamentous viral entry into host cell via pilus retraction" NARROW [GOC:bf, GOC:jl, VZ:981] is_a: GO:0039667 ! viral entry into host cell via pilus retraction created_by: rfoulger creation_date: 2013-09-04T14:33:18Z [Term] id: GO:0039669 name: viral entry into host cell via pilus retraction and membrane fusion namespace: biological_process def: "The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane." [GOC:bf, GOC:jl, PMID:20427561, VZ:981] comment: For annotation of viral pilus-binding proteins, see also 'viral attachment to host cell pilus ; GO:0039666'. is_a: GO:0039667 ! viral entry into host cell via pilus retraction relationship: has_part GO:0019064 ! fusion of virus membrane with host plasma membrane created_by: rfoulger creation_date: 2013-09-04T14:35:44Z [Term] id: GO:0039670 name: viral capsid, turret namespace: cellular_component def: "A turret-like appendage formed at the vertices of an icosahedral capsid." [GOC:jh2, PMID:20592081] is_a: GO:0098021 ! viral capsid, decoration relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: rfoulger creation_date: 2013-09-25T10:08:14Z [Term] id: GO:0039671 name: evasion by virus of host natural killer cell activity namespace: biological_process def: "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131] synonym: "evasion by virus of host natural killer cell response" EXACT [] synonym: "evasion by virus of host NK cell killing" EXACT [GOC:bf] synonym: "modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131] synonym: "protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710] synonym: "suppression by virus of host natural killer cell function" EXACT [PMID:15640804] synonym: "viral immunoevasion of host NK cell" EXACT [GOC:bf] is_a: GO:0030683 ! mitigation of host immune response by virus created_by: rfoulger creation_date: 2013-09-25T11:04:53Z [Term] id: GO:0039672 name: suppression by virus of host natural killer cell activation namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host." [GOC:bf, GOC:jl] synonym: "suppression by virus of host NK-cell activation" EXACT [GOC:bf, GOC:jl] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0039671 ! evasion by virus of host natural killer cell activity created_by: rfoulger creation_date: 2013-09-25T11:08:19Z [Term] id: GO:0039673 name: evasion by virus of host dendritic cell activity namespace: biological_process def: "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118] synonym: "evasion by virus of host dendritic cell response" EXACT [] synonym: "impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118] synonym: "modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118] is_a: GO:0030683 ! mitigation of host immune response by virus created_by: rfoulger creation_date: 2013-09-25T11:18:51Z [Term] id: GO:0039674 name: exit of virus from host cell nucleus namespace: biological_process def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus." [VZ:2177] xref: VZ:2177 "Nuclear exit of viral genome" is_a: GO:0051168 ! nuclear export is_a: GO:0075733 ! intracellular transport of virus is_a: GO:1902581 ! multi-organism cellular localization created_by: rfoulger creation_date: 2013-09-25T13:59:41Z [Term] id: GO:0039675 name: exit of virus from host cell nucleus through nuclear pore namespace: biological_process def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore." [PMID:12921991, VZ:1953] synonym: "exit of virus from host cell nucleus through nuclear pore complex" EXACT [] synonym: "nuclear pore exit of virus" EXACT [VZ:1953] synonym: "viral enome export through nuclear pore" EXACT [VZ:1953] xref: VZ:1953 "Genome export through nuclear pore" is_a: GO:0039674 ! exit of virus from host cell nucleus created_by: rfoulger creation_date: 2013-09-25T14:10:03Z [Term] id: GO:0039677 name: exit of virus from host cell nucleus via nuclear envelope disassembly namespace: biological_process def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus." [VZ:2176] synonym: "exit of virus from host cell nucleus via nuclear envelope breakdown" EXACT [VZ:2176] xref: VZ:2176 "Nuclear envelope breakdown" is_a: GO:0039674 ! exit of virus from host cell nucleus relationship: has_part GO:0051081 ! nuclear envelope disassembly created_by: rfoulger creation_date: 2013-09-25T14:10:03Z [Term] id: GO:0039678 name: viral genome ejection through host cell envelope namespace: biological_process def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171] comment: When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'. synonym: "phage genome ejection" NARROW [PMID:23385786] synonym: "viral genome injection through bacterial membranes" NARROW [UniProtKB-KW:KW-1171] is_a: GO:0046718 ! viral entry into host cell created_by: rfoulger creation_date: 2013-09-26T11:56:48Z [Term] id: GO:0039679 name: viral occlusion body namespace: cellular_component def: "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host." [UniProtKB-KW:KW-0842, VZ:1949] xref: VZ:1949 "Occlusion bodies" is_a: GO:0140220 ! pathogen-containing vacuole relationship: has_part GO:0019012 ! virion created_by: rfoulger creation_date: 2013-09-26T14:17:10Z [Term] id: GO:0039680 name: actin-dependent intracellular transport of virus towards nucleus namespace: biological_process def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments." [UniProtKB-KW:KW-1178, VZ:991] synonym: "actin-dependent intracellular transport of viral material towards nucleus" EXACT [] synonym: "actin-dependent inwards viral transport" EXACT [VZ:991] xref: VZ:991 "Actin-dependent inwards viral transport" is_a: GO:0075520 ! actin-dependent intracellular transport of virus is_a: GO:0075606 ! transport of viral material towards nucleus created_by: rfoulger creation_date: 2013-10-10T11:24:56Z [Term] id: GO:0039682 name: rolling circle viral DNA replication namespace: biological_process def: "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA." [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication] is_a: GO:0039687 ! viral DNA strand displacement replication created_by: rfoulger creation_date: 2013-10-17T14:13:51Z [Term] id: GO:0039683 name: rolling circle double-stranded viral DNA replication namespace: biological_process def: "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:2676] synonym: "dsDNA rolling circle replication" EXACT [VZ:2676] xref: VZ:2676 "dsDNA rolling circle replication" is_a: GO:0039682 ! rolling circle viral DNA replication created_by: rfoulger creation_date: 2013-10-17T14:15:04Z [Term] id: GO:0039684 name: rolling circle single-stranded viral DNA replication namespace: biological_process def: "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:1941] synonym: "ssDNA rolling circle replication" EXACT [VZ:1941] xref: VZ:1941 "ssDNA Rolling circle" is_a: GO:0039682 ! rolling circle viral DNA replication created_by: rfoulger creation_date: 2013-10-17T14:15:48Z [Term] id: GO:0039685 name: rolling hairpin viral DNA replication namespace: biological_process def: "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA." [GOC:bf, GOC:jl, VZ:2656] synonym: "ssDNA rolling hairpin viral DNA replication" EXACT [VZ:2656] xref: VZ:2656 "Rolling hairpin replication" is_a: GO:0039693 ! viral DNA genome replication created_by: rfoulger creation_date: 2013-10-17T14:33:55Z [Term] id: GO:0039686 name: bidirectional double-stranded viral DNA replication namespace: biological_process def: "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions." [GOC:bf, GOC:jl, VZ:1939] synonym: "viral bidirectional dsDNA replication" EXACT [VZ:1939] xref: VZ:1939 "dsDNA bidirectional replication" is_a: GO:0039693 ! viral DNA genome replication created_by: rfoulger creation_date: 2013-10-17T14:42:09Z [Term] id: GO:0039687 name: viral DNA strand displacement replication namespace: biological_process def: "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA)." [GOC:bf, GOC:jl, VZ:1940] xref: VZ:1940 "DNA strand displacement replication" is_a: GO:0039693 ! viral DNA genome replication created_by: rfoulger creation_date: 2013-10-17T14:48:40Z [Term] id: GO:0039688 name: viral double stranded DNA replication via reverse transcription namespace: biological_process def: "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:bf, GOC:jl, VZ:1938] synonym: "dsDNA replication via RNA intermediate" EXACT [GOC:bf, GOC:jl] synonym: "RNA-dependent viral DNA replication" RELATED [GOC:bf, GOC:jl] synonym: "viral RNA-dependent DNA replication" EXACT [GOC:bf, GOC:jl] xref: VZ:1938 "dsDNA(RT) replication/transcription" is_a: GO:0039693 ! viral DNA genome replication relationship: has_part GO:0001171 ! reverse transcription relationship: has_part GO:0039695 ! DNA-templated viral transcription created_by: rfoulger creation_date: 2013-10-17T15:00:08Z [Term] id: GO:0039689 name: negative stranded viral RNA replication namespace: biological_process def: "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA)." [GOC:bf, GOC:jl, VZ:1096] synonym: "(-)ss viral RNA replication" EXACT [VZ:1096] xref: VZ:1096 "Negative stranded RNA virus replication" is_a: GO:0039694 ! viral RNA genome replication relationship: has_part GO:0039696 ! RNA-templated viral transcription created_by: rfoulger creation_date: 2013-10-17T15:40:27Z [Term] id: GO:0039690 name: positive stranded viral RNA replication namespace: biological_process def: "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA." [GOC:bf, GOC:jl, VZ:1116] synonym: "ss(+) viral RNA replication" RELATED [VZ:1116] xref: VZ:1116 "Positive stranded RNA virus replication" is_a: GO:0039694 ! viral RNA genome replication created_by: rfoulger creation_date: 2013-10-17T15:45:40Z [Term] id: GO:0039691 name: double stranded viral RNA replication namespace: biological_process def: "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA." [GOC:bf, GOC:jl, VZ:1936] xref: VZ:1936 "Double-stranded RNA virus replication" is_a: GO:0039694 ! viral RNA genome replication relationship: has_part GO:0039696 ! RNA-templated viral transcription created_by: rfoulger creation_date: 2013-10-17T15:52:19Z [Term] id: GO:0039692 name: single stranded viral RNA replication via double stranded DNA intermediate namespace: biological_process alt_id: GO:0045090 def: "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II." [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937] synonym: "retroviral genome replication" EXACT [] synonym: "viral ssRNA replication via dsDNA intermediate" RELATED [GOC:bf] xref: VZ:1937 "ssRNA(RT) replication/transcription" is_a: GO:0039694 ! viral RNA genome replication relationship: has_part GO:0001171 ! reverse transcription relationship: has_part GO:0039695 ! DNA-templated viral transcription relationship: has_part GO:0044826 ! viral genome integration into host DNA created_by: rfoulger creation_date: 2013-10-17T15:59:43Z [Term] id: GO:0039693 name: viral DNA genome replication namespace: biological_process alt_id: GO:0039681 def: "The replication of a viral DNA genome." [GOC:bf, GOC:jl, VZ:915] synonym: "DNA-dependent viral DNA replication" EXACT [GOC:bf, GOC:jl] synonym: "viral DNA replication" EXACT [GOC:bf, GOC:jl] synonym: "viral DNA-dependent DNA replication" EXACT [] is_a: GO:0019079 ! viral genome replication created_by: rfoulger creation_date: 2013-10-23T15:22:31Z [Term] id: GO:0039694 name: viral RNA genome replication namespace: biological_process def: "The replication of a viral RNA genome." [GOC:bf, GOC:jl] is_a: GO:0019079 ! viral genome replication created_by: rfoulger creation_date: 2013-10-23T15:24:36Z [Term] id: GO:0039695 name: DNA-templated viral transcription namespace: biological_process def: "A transcription process that uses a viral DNA as a template." [GOC:bf, GOC:jl] xref: VZ:1942 "dsDNA templated transcription" is_a: GO:0019083 ! viral transcription created_by: rfoulger creation_date: 2013-10-28T13:25:20Z [Term] id: GO:0039696 name: RNA-templated viral transcription namespace: biological_process def: "A transcription process that uses viral RNA as a template." [GOC:bf, GOC:jl] is_a: GO:0019083 ! viral transcription created_by: rfoulger creation_date: 2013-10-28T13:28:01Z [Term] id: GO:0039697 name: negative stranded viral RNA transcription namespace: biological_process def: "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template." [VZ:1096] xref: VZ:1096 "Negative stranded RNA virus replication" is_a: GO:0039696 ! RNA-templated viral transcription created_by: rfoulger creation_date: 2013-10-28T14:41:41Z [Term] id: GO:0039698 name: polyadenylation of viral mRNA by polymerase stuttering namespace: biological_process def: "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." [VZ:1916] synonym: "polyA stuttering" EXACT [VZ:1916] xref: VZ:1916 "Negative-stranded RNA virus Polymerase stuttering" is_a: GO:0043631 ! RNA polyadenylation created_by: rfoulger creation_date: 2013-10-28T14:54:07Z [Term] id: GO:0039699 name: viral mRNA cap methylation namespace: biological_process def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a viral mRNA. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs." [UniProtKB-KW:KW-1196] synonym: "IFIT mRNA restriction evasion by virus" EXACT [UniProtKB-KW:KW-1196] is_a: GO:0039503 ! suppression by virus of host innate immune response created_by: rfoulger creation_date: 2013-11-06T14:39:17Z [Term] id: GO:0039700 name: fusion of viral membrane with host outer nuclear membrane namespace: biological_process def: "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit." [PMID:23057731, UniProtKB-KW:KW-1181] synonym: "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress" EXACT [GOC:bf] synonym: "viral primary envelope fusion with host outer nuclear membrane" EXACT [UniProtKB-KW:KW-1181] is_a: GO:0044800 ! multi-organism membrane fusion relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress created_by: rfoulger creation_date: 2013-11-06T15:07:46Z [Term] id: GO:0039701 name: microtubule-dependent intracellular transport of viral material towards cell periphery namespace: biological_process def: "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane." [UniProtKB-KW:KW-1189, VZ:1816] xref: VZ:1816 "Microtubular outwards viral transport" is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material created_by: rfoulger creation_date: 2013-11-06T16:09:57Z [Term] id: GO:0039702 name: viral budding via host ESCRT complex namespace: biological_process def: "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process." [UniProtKB-KW:KW-1187, VZ:1536] synonym: "host-assisted viral budding" BROAD [VZ:1536] synonym: "viral budding through the ESCRT machinery" RELATED [VZ:1536] xref: VZ:1536 "Viral budding via the host ESCRT complexes" is_a: GO:0046755 ! viral budding created_by: rfoulger creation_date: 2013-11-06T16:51:53Z [Term] id: GO:0039703 name: RNA replication namespace: biological_process def: "The cellular metabolic process in which a cell duplicates one or more molecules of RNA." [GOC:bf, GOC:jl] is_a: GO:0016070 ! RNA metabolic process relationship: has_part GO:0032774 ! RNA biosynthetic process created_by: rfoulger creation_date: 2013-11-21T16:53:29Z [Term] id: GO:0039704 name: viral translational shunt namespace: biological_process def: "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site." [PMID:15827182, PMID:18195037, VZ:608] comment: This term is intended to annotate gene products involved in the process of viral translational shunt, not viral proteins produced by this translation process. synonym: "ribosomal shunt initiation pathway" EXACT [PMID:18195037] xref: VZ:608 "Ribosomal shunt" is_a: GO:0019081 ! viral translation created_by: rfoulger creation_date: 2013-11-21T17:08:40Z [Term] id: GO:0039705 name: viral translational readthrough namespace: biological_process def: "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859] comment: This term is intended to annotate gene products involved in the process of viral translational readthrough, not viral proteins produced by this translation process. synonym: "viral RNA suppression of termination" RELATED [VZ:859] synonym: "viral stop codon readthrough" EXACT [VZ:859] xref: VZ:859 "RNA suppression of termination" is_a: GO:0006451 ! translational readthrough relationship: part_of GO:0019081 ! viral translation created_by: rfoulger creation_date: 2013-11-25T13:20:37Z [Term] id: GO:0039706 name: co-receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl] is_a: GO:0005515 ! protein binding created_by: rfoulger creation_date: 2013-11-25T14:41:42Z [Term] id: GO:0039707 name: pore formation by virus in membrane of host cell namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism." [GOC:bf, GOC:jl, PMID:12972148, UniProtKB-KW:KW-1182] synonym: "pore formation in membrane of host cell by virus" EXACT [GOC:bf] synonym: "viroporin" RELATED [PMID:12972148, UniProtKB-KW:KW-1182] is_a: GO:0016032 ! viral process is_a: GO:0044658 ! pore formation in membrane of host by symbiont created_by: rfoulger creation_date: 2013-11-25T15:33:33Z [Term] id: GO:0039708 name: nuclear capsid assembly namespace: biological_process def: "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly." [VZ:1516] xref: VZ:1516 "Nuclear capsid assembly" is_a: GO:0019069 ! viral capsid assembly intersection_of: GO:0019069 ! viral capsid assembly intersection_of: occurs_in GO:0042025 ! host cell nucleus relationship: occurs_in GO:0042025 ! host cell nucleus created_by: rfoulger creation_date: 2013-11-28T15:08:41Z [Term] id: GO:0039709 name: cytoplasmic capsid assembly namespace: biological_process def: "The assembly of a virus capsid that occurs in the cytoplasm." [VZ:1950] xref: VZ:1950 "Cytoplasmic capsid assembly/packaging" is_a: GO:0019069 ! viral capsid assembly intersection_of: GO:0019069 ! viral capsid assembly intersection_of: occurs_in GO:0030430 ! host cell cytoplasm relationship: occurs_in GO:0030430 ! host cell cytoplasm created_by: rfoulger creation_date: 2013-11-28T15:12:30Z [Term] id: GO:0039710 name: cytoplasmic icosahedral capsid assembly namespace: biological_process def: "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome." [VZ:1950] is_a: GO:0039709 ! cytoplasmic capsid assembly created_by: rfoulger creation_date: 2013-11-28T15:20:50Z [Term] id: GO:0039711 name: cytoplasmic helical capsid assembly namespace: biological_process def: "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome." [VZ:1950] is_a: GO:0039709 ! cytoplasmic capsid assembly created_by: rfoulger creation_date: 2013-11-28T15:23:39Z [Term] id: GO:0039712 name: induction by virus of host catalytic activity namespace: biological_process def: "Any viral process that activates or increases the frequency, rate or extent of host catalytic activity." [GOC:bf, GOC:jl] synonym: "induction by virus of host enzyme activity" EXACT [GOC:bf, GOC:jl] is_a: GO:0039516 ! modulation by virus of host catalytic activity is_a: GO:0043948 ! induction by symbiont of host catalytic activity created_by: rfoulger creation_date: 2013-12-19T13:21:45Z [Term] id: GO:0039713 name: viral factory namespace: cellular_component def: "An intracellular compartment in a host cell which increases the efficiency of viral replication and/or assembly, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951] synonym: "virus factory" EXACT [PMID:22440839] xref: VZ:1951 "Viral factories" is_a: GO:0033643 ! host cell part created_by: rfoulger creation_date: 2013-12-19T14:53:47Z [Term] id: GO:0039714 name: cytoplasmic viral factory namespace: cellular_component def: "A viral factory located in the cytoplasm of a host cell." [VZ:1951] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0039713 ! viral factory intersection_of: GO:0039713 ! viral factory intersection_of: part_of GO:0030430 ! host cell cytoplasm created_by: rfoulger creation_date: 2013-12-19T15:16:15Z [Term] id: GO:0039715 name: nuclear viral factory namespace: cellular_component def: "A viral factory located in the nucleus of a host cell." [VZ:1951] is_a: GO:0039713 ! viral factory intersection_of: GO:0039713 ! viral factory intersection_of: part_of GO:0042025 ! host cell nucleus relationship: part_of GO:0042025 ! host cell nucleus created_by: rfoulger creation_date: 2013-12-19T15:18:07Z [Term] id: GO:0039716 name: viroplasm viral factory namespace: cellular_component def: "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae." [VZ:1951, Wikipedia:Viroplasm] xref: Wikipedia:Viroplasm is_a: GO:0039714 ! cytoplasmic viral factory created_by: rfoulger creation_date: 2013-12-19T15:22:29Z [Term] id: GO:0039717 name: spherule viral factory namespace: cellular_component def: "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus." [VZ:1951] xref: Wikipedia:Viroplasm is_a: GO:0039714 ! cytoplasmic viral factory created_by: rfoulger creation_date: 2013-12-19T15:25:57Z [Term] id: GO:0039718 name: double membrane vesicle viral factory namespace: cellular_component def: "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae." [PMID:22440839, VZ:1951] synonym: "DMV viral factory" EXACT [VZ:1951] is_a: GO:0039714 ! cytoplasmic viral factory created_by: rfoulger creation_date: 2013-12-19T15:31:22Z [Term] id: GO:0039719 name: tube viral factory namespace: cellular_component def: "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories." [VZ:1951] is_a: GO:0039714 ! cytoplasmic viral factory created_by: rfoulger creation_date: 2013-12-19T15:34:56Z [Term] id: GO:0039720 name: virogenic stroma namespace: cellular_component def: "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled." [PMID:13358757, PMID:1433508, VZ:1951] synonym: "VS" EXACT [VZ:1951] is_a: GO:0039715 ! nuclear viral factory created_by: rfoulger creation_date: 2013-12-19T15:45:32Z [Term] id: GO:0039721 name: peristromal region viral factory namespace: cellular_component def: "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses." [PMID:18434402, VZ:1951] synonym: "PR" RELATED [PMID:18434402, VZ:1951] is_a: GO:0039715 ! nuclear viral factory created_by: rfoulger creation_date: 2013-12-19T15:54:00Z [Term] id: GO:0039722 name: suppression by virus of host toll-like receptor signaling pathway namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism." [UniProtKB-KW:KW-1225] synonym: "inhibition of host TLR pathway by virus" EXACT [UniProtKB-KW:KW-1125] synonym: "suppression by virus of host TLR signaling pathway" EXACT [] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:0039503 ! suppression by virus of host innate immune response created_by: rfoulger creation_date: 2014-01-06T11:39:58Z [Term] id: GO:0039723 name: suppression by virus of host TBK1 activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [PR:000001779, UniProtKB-KW:KW-1223] comment: When TBK1 acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659. synonym: "inhibition of host TBK1 by virus" EXACT [UniProtKB-KW:KW-1223] is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039584 ! suppression by virus of host protein kinase activity created_by: rfoulger creation_date: 2014-01-06T12:04:44Z [Term] id: GO:0039724 name: suppression by virus of host IKBKE activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PR:000001778, UniProtKB-KW:KW-1224] comment: When IKBKE acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659. synonym: "inhibition of host IKBKE by virus" EXACT [UniProtKB-KW:KW-1224] is_a: GO:0039503 ! suppression by virus of host innate immune response is_a: GO:0039507 ! suppression by virus of host molecular function created_by: rfoulger creation_date: 2014-01-06T12:15:03Z [Term] id: GO:0040001 name: establishment of mitotic spindle localization namespace: biological_process alt_id: GO:0018986 alt_id: GO:0030605 alt_id: GO:0030606 alt_id: GO:0030608 alt_id: GO:0030610 def: "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "establishment of mitotic spindle localisation" EXACT [GOC:mah] synonym: "mitotic spindle positioning" EXACT [] synonym: "mitotic spindle positioning and orientation" NARROW [] synonym: "mitotic spindle positioning or orientation" EXACT [] synonym: "spindle positioning during mitosis" RELATED [] synonym: "spindle positioning involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051293 ! establishment of spindle localization is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0051293 ! establishment of spindle localization intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0040002 name: collagen and cuticulin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle anabolism" EXACT [] synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT [] synonym: "collagen and cuticulin-based cuticle formation" EXACT [] synonym: "collagen and cuticulin-based cuticle synthesis" EXACT [] is_a: GO:0042335 ! cuticle development [Term] id: GO:0040003 name: chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "chitin-based cuticle anabolism" EXACT [] synonym: "chitin-based cuticle biosynthetic process" EXACT [] synonym: "chitin-based cuticle formation" EXACT [] synonym: "chitin-based cuticle synthesis" EXACT [] is_a: GO:0042335 ! cuticle development [Term] id: GO:0040004 name: collagen and cuticulin-based cuticle attachment to epithelium namespace: biological_process def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] synonym: "cuticular attachment to epithelium" BROAD [] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0040005 name: chitin-based cuticle attachment to epithelium namespace: biological_process def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "cuticular attachment to epithelium" BROAD [] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0040006 name: obsolete protein-based cuticle attachment to epithelium namespace: biological_process def: "OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "cuticular attachment to epithelium" BROAD [] synonym: "protein-based cuticle attachment to epithelium" EXACT [] is_obsolete: true consider: GO:0040004 consider: GO:0040005 [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040007 ! growth relationship: regulates GO:0040007 ! growth [Term] id: GO:0040009 name: regulation of growth rate namespace: biological_process def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. is_a: GO:0040008 ! regulation of growth [Term] id: GO:0040010 name: positive regulation of growth rate namespace: biological_process def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. synonym: "activation of growth rate" NARROW [] synonym: "stimulation of growth rate" NARROW [] synonym: "up regulation of growth rate" EXACT [] synonym: "up-regulation of growth rate" EXACT [] synonym: "upregulation of growth rate" EXACT [] is_a: GO:0040009 ! regulation of growth rate is_a: GO:0045927 ! positive regulation of growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: MIPS_funcat:02.45.11 is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040011 ! locomotion relationship: regulates GO:0040011 ! locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040011 ! locomotion relationship: negatively_regulates GO:0040011 ! locomotion [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035264 ! multicellular organism growth relationship: regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035264 ! multicellular organism growth relationship: negatively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040011 ! locomotion relationship: positively_regulates GO:0040011 ! locomotion [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035264 ! multicellular organism growth relationship: positively_regulates GO:0035264 ! multicellular organism growth [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009790 ! embryo development relationship: positively_regulates GO:0009790 ! embryo development [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140013 ! meiotic nuclear division relationship: regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0040021 name: hermaphrodite germ-line sex determination namespace: biological_process alt_id: GO:0042005 def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems] is_a: GO:0018992 ! germ-line sex determination [Term] id: GO:0040022 name: feminization of hermaphroditic germ-line namespace: biological_process def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems] is_a: GO:0040021 ! hermaphrodite germ-line sex determination [Term] id: GO:0040024 name: dauer larval development namespace: biological_process def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X] is_a: GO:0002119 ! nematode larval development [Term] id: GO:0040025 name: vulval development namespace: biological_process def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X] is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002119 ! nematode larval development [Term] id: GO:0040026 name: positive regulation of vulval development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] synonym: "activation of vulval development" RELATED [] synonym: "stimulation of vulval development" RELATED [] synonym: "up regulation of vulval development" RELATED [] synonym: "up-regulation of vulval development" RELATED [] synonym: "upregulation of vulval development" RELATED [] is_a: GO:0040028 ! regulation of vulval development is_a: GO:0061063 ! positive regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040025 ! vulval development relationship: positively_regulates GO:0040025 ! vulval development [Term] id: GO:0040027 name: negative regulation of vulval development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] synonym: "down regulation of vulval development" EXACT [] synonym: "down-regulation of vulval development" EXACT [] synonym: "downregulation of vulval development" EXACT [] synonym: "inhibition of vulval development" NARROW [] is_a: GO:0040028 ! regulation of vulval development is_a: GO:0061064 ! negative regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040025 ! vulval development relationship: negatively_regulates GO:0040025 ! vulval development [Term] id: GO:0040028 name: regulation of vulval development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma] is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040025 ! vulval development relationship: regulates GO:0040025 ! vulval development [Term] id: GO:0040029 name: regulation of gene expression, epigenetic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] subset: goslim_plant is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0040030 name: regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551] synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0040031 name: snRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl] is_a: GO:0009451 ! RNA modification is_a: GO:0016073 ! snRNA metabolic process [Term] id: GO:0040032 name: post-embryonic body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888] comment: Note that this term was 'body morphogenesis (sensu Nematoda)'. is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0010171 ! body morphogenesis [Term] id: GO:0040033 name: negative regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb] synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0045974 ! regulation of translation, ncRNA-mediated [Term] id: GO:0040034 name: regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] synonym: "developmental timing" RELATED [] synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0040035 name: hermaphrodite genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888] is_a: GO:0008406 ! gonad development is_a: GO:0048806 ! genitalia development [Term] id: GO:0040036 name: regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "regulation of FGF receptor signaling pathway" EXACT [] synonym: "regulation of FGF receptor signalling pathway" EXACT [] synonym: "regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0040037 name: negative regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of FGF receptor signaling pathway" EXACT [] synonym: "negative regulation of FGF receptor signalling pathway" EXACT [] synonym: "negative regulation of FGFR signaling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0040038 name: polar body extrusion after meiotic divisions namespace: biological_process def: "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033206 ! meiotic cytokinesis relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0040039 name: inductive cell migration namespace: biological_process def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882] is_a: GO:0016477 ! cell migration [Term] id: GO:0040040 name: thermosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems] synonym: "behavioral response to temperature stimulus" EXACT [] synonym: "behavioural response to temperature stimulus" EXACT [] synonym: "thermosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0042000 name: translocation of peptides or proteins into host namespace: biological_process alt_id: GO:0051808 def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "translocation of peptides or proteins into other organism during symbiotic interaction" BROAD [GOC:tb] synonym: "translocation of peptides or proteins into other organism involved in symbiotic interaction" BROAD [] synonym: "transport of peptides or proteins into host" EXACT [] synonym: "transport of peptides or proteins into other organism during symbiotic interaction" BROAD [] is_a: GO:0015031 ! protein transport is_a: GO:0044417 ! translocation of molecules into host is_a: GO:0044766 ! multi-organism transport [Term] id: GO:0042001 name: hermaphrodite somatic sex determination namespace: biological_process alt_id: GO:0042002 def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0018993 ! somatic sex determination [Term] id: GO:0042003 name: masculinization of hermaphrodite soma namespace: biological_process def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0042001 ! hermaphrodite somatic sex determination [Term] id: GO:0042004 name: feminization of hermaphrodite soma namespace: biological_process def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0042001 ! hermaphrodite somatic sex determination [Term] id: GO:0042006 name: masculinization of hermaphroditic germ-line namespace: biological_process def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems] is_a: GO:0040021 ! hermaphrodite germ-line sex determination [Term] id: GO:0042007 name: interleukin-18 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-18." [GOC:jl] synonym: "IL-18 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042008 name: interleukin-18 receptor activity namespace: molecular_function def: "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-18 receptor activity" EXACT [GOC:mah] synonym: "IL-18R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042007 ! interleukin-18 binding relationship: part_of GO:0035655 ! interleukin-18-mediated signaling pathway [Term] id: GO:0042009 name: interleukin-15 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-15." [GOC:jl] synonym: "IL-15 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042010 name: interleukin-15 receptor activity namespace: molecular_function def: "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-15 receptor activity" EXACT [GOC:mah] synonym: "IL-15R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042009 ! interleukin-15 binding relationship: part_of GO:0035723 ! interleukin-15-mediated signaling pathway [Term] id: GO:0042011 name: interleukin-16 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-16." [GOC:jl] synonym: "IL-16 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042012 name: interleukin-16 receptor activity namespace: molecular_function def: "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-16 receptor activity" EXACT [GOC:mah] synonym: "IL-16R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042011 ! interleukin-16 binding [Term] id: GO:0042013 name: interleukin-19 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-19." [GOC:jl] synonym: "IL-19 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042014 name: interleukin-19 receptor activity namespace: molecular_function def: "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-19 receptor activity" EXACT [GOC:mah] synonym: "IL-19R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042013 ! interleukin-19 binding [Term] id: GO:0042015 name: interleukin-20 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-20." [GOC:jl] synonym: "IL-20 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042016 name: interleukin-20 receptor activity namespace: molecular_function def: "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-20 receptor activity" EXACT [GOC:mah] synonym: "IL-20R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042015 ! interleukin-20 binding [Term] id: GO:0042017 name: interleukin-22 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-22." [GOC:jl] synonym: "IL-22 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042018 name: interleukin-22 receptor activity namespace: molecular_function def: "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-22 receptor activity" EXACT [GOC:mah] synonym: "IL-22R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042017 ! interleukin-22 binding [Term] id: GO:0042019 name: interleukin-23 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-23." [GOC:jl] synonym: "IL-23 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042020 name: interleukin-23 receptor activity namespace: molecular_function def: "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-23 receptor activity" EXACT [GOC:mah] synonym: "IL-23R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0042019 ! interleukin-23 binding relationship: part_of GO:0038155 ! interleukin-23-mediated signaling pathway [Term] id: GO:0042021 name: granulocyte macrophage colony-stimulating factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai] synonym: "GM-CSF complex binding" EXACT [] synonym: "GMC-SF complex binding" EXACT [] synonym: "granulocyte macrophage colony stimulating factor complex binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0042022 name: interleukin-12 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:ebc, GOC:mah, PMID:10971505] synonym: "IL-12 receptor complex" EXACT [GOC:add] synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0042023 name: DNA endoreduplication namespace: biological_process def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states. synonym: "DNA endoreplication" EXACT [] synonym: "DNA re-duplication" EXACT [] is_a: GO:0044786 ! cell cycle DNA replication relationship: has_part GO:0006270 ! DNA replication initiation [Term] id: GO:0042025 name: host cell nucleus namespace: cellular_component alt_id: GO:0033649 def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0033648 ! host intracellular membrane-bounded organelle [Term] id: GO:0042026 name: protein refolding namespace: biological_process def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] synonym: "heat shock protein activity" RELATED [] is_a: GO:0006457 ! protein folding [Term] id: GO:0042027 name: obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8] comment: This term was made obsolete because it is contains gene product specific characteristics. synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" EXACT [] is_obsolete: true consider: GO:0003755 [Term] id: GO:0042029 name: obsolete fibrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320] comment: This term was made obsolete because it represents a gene product. synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72] synonym: "fibrolase activity" EXACT [] xref: EC:3.4.24.72 xref: MetaCyc:3.4.24.72-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0042030 name: ATPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl] synonym: "adenosinetriphosphatase inhibitor" EXACT [] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0060590 ! ATPase regulator activity relationship: negatively_regulates GO:0016887 ! ATPase activity [Term] id: GO:0042031 name: obsolete angiotensin-converting enzyme inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl] comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term. synonym: "ACE inhibitor" EXACT [] synonym: "angiotensin-converting enzyme inhibitor activity" EXACT [] synonym: "peptidyl dipeptidase A inhibitor" EXACT [] xref: Wikipedia:ACE_inhibitor is_obsolete: true replaced_by: GO:0060422 [Term] id: GO:0042033 name: chemokine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377] synonym: "chemokine anabolism" EXACT [] synonym: "chemokine biosynthesis" EXACT [] synonym: "chemokine formation" EXACT [] synonym: "chemokine synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:0050755 ! chemokine metabolic process relationship: part_of GO:0032602 ! chemokine production [Term] id: GO:0042034 name: peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine namespace: biological_process def: "The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester." [RESID:AA0318] synonym: "peptidyl-lysine esterification" EXACT [] xref: RESID:AA0318 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0042035 name: regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "regulation of cytokine anabolism" EXACT [] synonym: "regulation of cytokine biosynthesis" EXACT [] synonym: "regulation of cytokine formation" EXACT [] synonym: "regulation of cytokine synthesis" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042089 ! cytokine biosynthetic process relationship: regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042036 name: negative regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "down regulation of cytokine biosynthetic process" EXACT [] synonym: "down-regulation of cytokine biosynthetic process" EXACT [] synonym: "downregulation of cytokine biosynthetic process" EXACT [] synonym: "inhibition of cytokine biosynthetic process" NARROW [] synonym: "negative regulation of cytokine anabolism" EXACT [] synonym: "negative regulation of cytokine biosynthesis" EXACT [] synonym: "negative regulation of cytokine formation" EXACT [] synonym: "negative regulation of cytokine synthesis" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042089 ! cytokine biosynthetic process relationship: negatively_regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042037 name: peptidyl-histidine methylation, to form pros-methylhistidine namespace: biological_process alt_id: GO:0042260 def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073] synonym: "peptidyl-histidine pros-methylation" EXACT [] xref: RESID:AA0073 is_a: GO:0018021 ! peptidyl-histidine methylation [Term] id: GO:0042038 name: peptidyl-histidine methylation, to form tele-methylhistidine namespace: biological_process alt_id: GO:0042261 def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317] synonym: "peptidyl-histidine tele-methylation" EXACT [] xref: RESID:AA0317 is_a: GO:0018021 ! peptidyl-histidine methylation [Term] id: GO:0042039 name: vanadium incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414] synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0042040 name: metal incorporation into metallo-molybdopterin complex namespace: biological_process def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0042042 name: tungsten incorporation into tungsten-molybdopterin complex namespace: biological_process def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai] is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex [Term] id: GO:0042043 name: neurexin family protein binding namespace: molecular_function alt_id: GO:0019963 def: "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512] synonym: "neuroligin" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042044 name: fluid transport namespace: biological_process def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0042045 name: epithelial fluid transport namespace: biological_process def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] is_a: GO:0042044 ! fluid transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0042046 name: W-molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco metabolic process" BROAD [] synonym: "Moco metabolism" BROAD [] synonym: "W-molybdopterin cofactor metabolism" EXACT [] is_a: GO:0043545 ! molybdopterin cofactor metabolic process [Term] id: GO:0042047 name: W-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco biosynthesis" BROAD [] synonym: "Moco biosynthetic process" BROAD [] synonym: "W-molybdopterin cofactor anabolism" EXACT [] synonym: "W-molybdopterin cofactor biosynthesis" EXACT [] synonym: "W-molybdopterin cofactor formation" EXACT [] synonym: "W-molybdopterin cofactor synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: has_part GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex [Term] id: GO:0042048 name: olfactory behavior namespace: biological_process def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] synonym: "behavioral response to scent" EXACT [] synonym: "behavioral response to smell" EXACT [] synonym: "behavioural response to odour" EXACT [] synonym: "behavioural response to scent" EXACT [] synonym: "behavioural response to smell" EXACT [] synonym: "olfactory behaviour" EXACT [] is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0042049 name: cellular acyl-CoA homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb] synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0030002 ! cellular anion homeostasis [Term] id: GO:0042051 name: compound eye photoreceptor development namespace: biological_process def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] synonym: "adult eye photoreceptor development" NARROW [] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0042052 name: rhabdomere development namespace: biological_process def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] synonym: "rhabdomere organization" EXACT [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0042053 name: regulation of dopamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "regulation of dopamine metabolism" EXACT [] is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042417 ! dopamine metabolic process relationship: regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0042054 name: histone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43] synonym: "histone methylase activity" EXACT [GOC:mah] is_a: GO:0008276 ! protein methyltransferase activity relationship: part_of GO:0016571 ! histone methylation [Term] id: GO:0042056 name: chemoattractant activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "attractant" BROAD [] is_a: GO:0048018 ! receptor ligand activity relationship: part_of GO:0050918 ! positive chemotaxis [Term] id: GO:0042057 name: obsolete transforming growth factor beta receptor anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "TGF-beta receptor anchoring activity" EXACT [] synonym: "TGFbeta receptor anchoring activity" EXACT [] synonym: "transforming growth factor beta receptor anchor activity" EXACT [] synonym: "transforming growth factor beta receptor anchoring activity" EXACT [] is_obsolete: true consider: GO:0005160 consider: GO:0008104 [Term] id: GO:0042058 name: regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "regulation of EGF receptor signaling pathway" EXACT [] synonym: "regulation of EGF receptor signalling pathway" EXACT [] synonym: "regulation of EGFR signaling pathway" EXACT [] is_a: GO:1901184 ! regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0042059 name: negative regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of EGF receptor signaling pathway" EXACT [] synonym: "negative regulation of EGF receptor signalling pathway" EXACT [] synonym: "negative regulation of EGFR signaling pathway" EXACT [] is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:1901185 ! negative regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0042060 name: wound healing namespace: biological_process def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] xref: Wikipedia:Wound_healing is_a: GO:0009611 ! response to wounding [Term] id: GO:0042062 name: long-term strengthening of neuromuscular junction namespace: biological_process def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd] comment: This term was added by GO_REF:0000021. is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: part_of GO:0008582 ! regulation of synaptic growth at neuromuscular junction [Term] id: GO:0042063 name: gliogenesis namespace: biological_process def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] synonym: "glial cell generation" EXACT systematic_synonym [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0042064 name: obsolete cell adhesion receptor regulator activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cell adhesion receptor regulator activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0030155 [Term] id: GO:0042065 name: glial cell growth namespace: biological_process def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0042066 name: perineurial glial growth namespace: biological_process def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560] is_a: GO:0042065 ! glial cell growth [Term] id: GO:0042067 name: establishment of ommatidial planar polarity namespace: biological_process def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0042068 name: regulation of pteridine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] synonym: "regulation of pteridine metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019889 ! pteridine metabolic process relationship: regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0042069 name: regulation of catecholamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] synonym: "regulation of catecholamine metabolism" EXACT [] is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006584 ! catecholamine metabolic process relationship: regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042070 name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0048127 def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD [] synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD [] synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD [] synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD [] synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051658 ! maintenance of nucleus location is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification intersection_of: GO:0051658 ! maintenance of nucleus location intersection_of: part_of GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0042071 name: leucokinin receptor activity namespace: molecular_function def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741] is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0042072 name: obsolete cell adhesion receptor inhibitor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cell adhesion receptor inhibitor activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0007162 [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process alt_id: GO:0035734 def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098840 ! protein transport along microtubule relationship: occurs_in GO:0005929 ! cilium relationship: part_of GO:0044782 ! cilium organization [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0042075 name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide namespace: biological_process def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] xref: RESID:AA0310 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0042076 name: protein phosphate-linked glycosylation namespace: biological_process def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424] synonym: "phosphoglycosylation" EXACT [] synonym: "protein amino acid phosphate-linked glycosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0042077 name: protein phosphate-linked glycosylation via serine namespace: biological_process def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah] synonym: "protein amino acid phosphate-linked glycosylation via serine" EXACT [GOC:bf] is_a: GO:0042076 ! protein phosphate-linked glycosylation [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process alt_id: GO:0048131 def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0042079 name: obsolete GPI/GSI anchor metabolic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "GPI/GSI anchor metabolic process" EXACT [] is_obsolete: true consider: GO:0006505 consider: GO:0042081 [Term] id: GO:0042080 name: obsolete GPI/GSI anchor biosynthetic process namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "GPI/GSI anchor anabolism" EXACT [] synonym: "GPI/GSI anchor biosynthesis" EXACT [] synonym: "GPI/GSI anchor biosynthetic process" EXACT [] synonym: "GPI/GSI anchor formation" EXACT [] synonym: "GPI/GSI anchor synthesis" EXACT [] is_obsolete: true consider: GO:0006506 consider: GO:0042082 [Term] id: GO:0042081 name: GSI anchor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators] synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] synonym: "GSI anchor metabolism" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0042082 name: GSI anchor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg] synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] synonym: "GSI anchor anabolism" EXACT [] synonym: "GSI anchor biosynthesis" EXACT [] synonym: "GSI anchor formation" EXACT [] synonym: "GSI anchor synthesis" EXACT [] is_a: GO:0006497 ! protein lipidation is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0042081 ! GSI anchor metabolic process [Term] id: GO:0042083 name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042084 name: 5-methyltetrahydrofolate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042085 name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042086 name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0042088 name: T-helper 1 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149] synonym: "Th1 immune response" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0042089 name: cytokine biosynthetic process namespace: biological_process alt_id: GO:0042032 def: "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732, ISBN:0198599471] synonym: "cytokine anabolism" EXACT [] synonym: "cytokine biosynthesis" EXACT [] synonym: "cytokine formation" EXACT [] synonym: "cytokine synthesis" EXACT [] synonym: "induction of cytokines" NARROW [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0042107 ! cytokine metabolic process relationship: part_of GO:0001816 ! cytokine production [Term] id: GO:0042090 name: interleukin-12 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "IL-12 biosynthesis" EXACT [] synonym: "IL-12 biosynthetic process" EXACT [] synonym: "interleukin-12 anabolism" EXACT [] synonym: "interleukin-12 biosynthesis" EXACT [] synonym: "interleukin-12 formation" EXACT [] synonym: "interleukin-12 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032615 ! interleukin-12 production [Term] id: GO:0042091 name: interleukin-10 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "IL-10 biosynthesis" EXACT [] synonym: "IL-10 biosynthetic process" EXACT [] synonym: "interleukin-10 anabolism" EXACT [] synonym: "interleukin-10 biosynthesis" EXACT [] synonym: "interleukin-10 formation" EXACT [] synonym: "interleukin-10 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032613 ! interleukin-10 production [Term] id: GO:0042092 name: type 2 immune response namespace: biological_process def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518] synonym: "T-helper 2 type immune response" NARROW [GOC:add] synonym: "Th2 immune response" NARROW [GOC:add] is_a: GO:0006955 ! immune response [Term] id: GO:0042093 name: T-helper cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] synonym: "helper T cell differentiation" EXACT [CL:0000912] synonym: "T-helper cell development" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response [Term] id: GO:0042094 name: interleukin-2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "IL-2 biosynthesis" EXACT [] synonym: "IL-2 biosynthetic process" EXACT [] synonym: "interleukin-2 anabolism" EXACT [] synonym: "interleukin-2 biosynthesis" EXACT [] synonym: "interleukin-2 formation" EXACT [] synonym: "interleukin-2 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032623 ! interleukin-2 production [Term] id: GO:0042095 name: interferon-gamma biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:go_curators, PR:000000017] synonym: "IFN-gamma biosynthesis" EXACT [] synonym: "IFN-gamma biosynthetic process" EXACT [] synonym: "interferon type II biosynthesis" BROAD [] synonym: "interferon type II biosynthetic process" BROAD [] synonym: "interferon-gamma anabolism" EXACT [] synonym: "interferon-gamma biosynthesis" EXACT [] synonym: "interferon-gamma formation" EXACT [] synonym: "interferon-gamma synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032609 ! interferon-gamma production [Term] id: GO:0042096 name: obsolete alpha-beta T cell receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. synonym: "alpha-beta T cell receptor activity" EXACT [] is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0042097 name: interleukin-4 biosynthetic process namespace: biological_process alt_id: GO:0042224 def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "IL-4 biosynthesis" EXACT [] synonym: "IL-4 biosynthetic process" EXACT [] synonym: "interleukin-4 anabolism" EXACT [] synonym: "interleukin-4 biosynthesis" EXACT [] synonym: "interleukin-4 formation" EXACT [] synonym: "interleukin-4 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032633 ! interleukin-4 production [Term] id: GO:0042098 name: T cell proliferation namespace: biological_process alt_id: GO:0042111 def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] synonym: "T lymphocyte proliferation" EXACT [] synonym: "T-cell proliferation" EXACT [] synonym: "T-lymphocyte proliferation" EXACT [] is_a: GO:0042110 ! T cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0042099 name: obsolete gamma-delta T cell receptor activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. synonym: "gamma-delta T cell receptor activity" EXACT [] is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0042100 name: B cell proliferation namespace: biological_process alt_id: GO:0042114 def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] synonym: "B lymphocyte proliferation" EXACT [] synonym: "B-cell proliferation" EXACT [] synonym: "B-lymphocyte proliferation" EXACT [] is_a: GO:0042113 ! B cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0042101 name: T cell receptor complex namespace: cellular_component def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149] synonym: "T lymphocyte receptor complex" EXACT [] synonym: "T-cell receptor complex" EXACT [] synonym: "T-lymphocyte receptor complex" EXACT [] synonym: "TCR" RELATED [] synonym: "TCR complex" EXACT [GOC:bf] xref: Wikipedia:T_cell_receptor is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0042102 name: positive regulation of T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] synonym: "activation of T cell proliferation" NARROW [] synonym: "positive regulation of T lymphocyte proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] synonym: "stimulation of T cell proliferation" NARROW [] synonym: "up regulation of T cell proliferation" EXACT [] synonym: "up-regulation of T cell proliferation" EXACT [] synonym: "upregulation of T cell proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042098 ! T cell proliferation relationship: positively_regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042103 name: positive regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] synonym: "activation of T cell homeostatic proliferation" NARROW [] synonym: "positive regulation of resting T cell proliferation" EXACT [] synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] synonym: "stimulation of T cell homeostatic proliferation" NARROW [] synonym: "up regulation of T cell homeostatic proliferation" EXACT [] synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] synonym: "upregulation of T cell homeostatic proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001777 ! T cell homeostatic proliferation relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0042104 name: positive regulation of activated T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl] synonym: "activation of activated T cell proliferation" NARROW [] synonym: "positive regulation of activated T lymphocyte proliferation" EXACT [] synonym: "positive regulation of activated T-cell proliferation" EXACT [] synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT [] synonym: "stimulation of activated T cell proliferation" NARROW [] synonym: "up regulation of activated T cell proliferation" EXACT [] synonym: "up-regulation of activated T cell proliferation" EXACT [] synonym: "upregulation of activated T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046006 ! regulation of activated T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050798 ! activated T cell proliferation relationship: positively_regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0042105 name: alpha-beta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149] synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] synonym: "alpha-beta T-cell receptor complex" EXACT [] synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] synonym: "alpha-beta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042106 name: gamma-delta T cell receptor complex namespace: cellular_component def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149] synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] synonym: "gamma-delta T-cell receptor complex" EXACT [] synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] synonym: "gamma-delta TCR complex" EXACT [] is_a: GO:0042101 ! T cell receptor complex [Term] id: GO:0042107 name: cytokine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GO_REF:0000022, GOC:bf, GOC:BHF, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "cytokine metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0042108 name: positive regulation of cytokine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] synonym: "activation of cytokine biosynthetic process" NARROW [] synonym: "positive regulation of cytokine anabolism" EXACT [] synonym: "positive regulation of cytokine biosynthesis" EXACT [] synonym: "positive regulation of cytokine formation" EXACT [] synonym: "positive regulation of cytokine synthesis" EXACT [] synonym: "stimulation of cytokine biosynthetic process" NARROW [] synonym: "up regulation of cytokine biosynthetic process" EXACT [] synonym: "up-regulation of cytokine biosynthetic process" EXACT [] synonym: "upregulation of cytokine biosynthetic process" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042089 ! cytokine biosynthetic process relationship: positively_regulates GO:0042089 ! cytokine biosynthetic process [Term] id: GO:0042109 name: lymphotoxin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "LTA biosynthesis" BROAD [] synonym: "LTA biosynthetic process" BROAD [] synonym: "lymphotoxin A anabolism" EXACT [] synonym: "lymphotoxin A biosynthesis" EXACT [] synonym: "lymphotoxin A formation" EXACT [] synonym: "lymphotoxin A synthesis" EXACT [] synonym: "lymphotoxin-alpha biosynthesis" EXACT [] synonym: "lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "TNF-B biosynthesis" EXACT [] synonym: "TNF-B biosynthetic process" EXACT [] synonym: "TNF-beta biosynthesis" EXACT [] synonym: "TNF-beta biosynthetic process" EXACT [] synonym: "tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032641 ! lymphotoxin A production [Term] id: GO:0042110 name: T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] synonym: "T lymphocyte activation" EXACT [] synonym: "T-cell activation" EXACT [] synonym: "T-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042113 name: B cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] synonym: "B lymphocyte activation" EXACT [] synonym: "B-cell activation" EXACT [] synonym: "B-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0042116 name: macrophage activation namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] synonym: "macrophage polarization" EXACT [] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042117 name: monocyte activation namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0042118 name: endothelial cell activation namespace: biological_process def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484] is_a: GO:0001775 ! cell activation [Term] id: GO:0042119 name: neutrophil activation namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0036230 ! granulocyte activation [Term] id: GO:0042120 name: alginic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] synonym: "alginate metabolic process" EXACT [] synonym: "alginate metabolism" EXACT [] synonym: "alginic acid metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0042121 name: alginic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] synonym: "alginate biosynthesis" EXACT [] synonym: "alginate biosynthetic process" EXACT [] synonym: "alginic acid anabolism" EXACT [] synonym: "alginic acid biosynthesis" EXACT [] synonym: "alginic acid formation" EXACT [] synonym: "alginic acid synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0042120 ! alginic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0042122 name: alginic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] synonym: "alginate catabolic process" EXACT [] synonym: "alginate catabolism" EXACT [] synonym: "alginic acid breakdown" EXACT [] synonym: "alginic acid catabolism" EXACT [] synonym: "alginic acid degradation" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0042123 name: glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0042124 name: 1,3-beta-glucanosyltransferase activity namespace: molecular_function def: "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation." [GOC:jl, PMID:10809732] is_a: GO:0042123 ! glucanosyltransferase activity [Term] id: GO:0042125 name: protein galactosylation namespace: biological_process def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl, GOC:pr] synonym: "protein amino acid galactosylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.02 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0042126 name: nitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] synonym: "nitrate metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:2001057 ! reactive nitrogen species metabolic process [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008283 ! cell population proliferation relationship: regulates GO:0008283 ! cell population proliferation [Term] id: GO:0042128 name: nitrate assimilation namespace: biological_process def: "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899] synonym: "assimilatory nitrate reduction" EXACT [] xref: MetaCyc:PWY-381 xref: MIPS_funcat:01.02.01.02 is_a: GO:0042126 ! nitrate metabolic process is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0042129 name: regulation of T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] synonym: "regulation of T lymphocyte proliferation" EXACT [] synonym: "regulation of T-cell proliferation" EXACT [] synonym: "regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042098 ! T cell proliferation relationship: regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042130 name: negative regulation of T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] synonym: "down regulation of T cell proliferation" EXACT [] synonym: "down-regulation of T cell proliferation" EXACT [] synonym: "downregulation of T cell proliferation" EXACT [] synonym: "inhibition of T cell proliferation" NARROW [] synonym: "negative regulation of T lymphocyte proliferation" EXACT [] synonym: "negative regulation of T-cell proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042098 ! T cell proliferation relationship: negatively_regulates GO:0042098 ! T cell proliferation [Term] id: GO:0042131 name: thiamine phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate." [PMID:197075] synonym: "thiamin monophosphate phosphatase" EXACT [] synonym: "thiamin phosphate phosphatase activity" EXACT [] synonym: "ThMPase" EXACT [] is_a: GO:0003993 ! acid phosphatase activity [Term] id: GO:0042132 name: fructose 1,6-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11] synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "FBPase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00] synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11] synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11] xref: EC:3.1.3.11 xref: MetaCyc:F16BDEPHOS-RXN xref: Reactome:R-HSA-70479 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate" xref: RHEA:11064 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0042133 name: neurotransmitter metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] subset: goslim_pir synonym: "neurotransmitter metabolism" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0042134 name: rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." [GOC:jl] synonym: "pre-rRNA binding" EXACT [PMID:3327689] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0042135 name: neurotransmitter catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] subset: goslim_synapse synonym: "neurotransmitter breakdown" EXACT [] synonym: "neurotransmitter catabolism" EXACT [] synonym: "neurotransmitter degradation" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042136 name: neurotransmitter biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] subset: goslim_synapse synonym: "neurotransmitter anabolism" EXACT [] synonym: "neurotransmitter biosynthesis" EXACT [] synonym: "neurotransmitter biosynthesis and storage" BROAD [] synonym: "neurotransmitter biosynthetic process and storage" BROAD [] synonym: "neurotransmitter formation" EXACT [] synonym: "neurotransmitter synthesis" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0042137 name: sequestering of neurotransmitter namespace: biological_process def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai] synonym: "neurotransmitter biosynthesis and storage" RELATED [] synonym: "neurotransmitter biosynthetic process and storage" RELATED [] synonym: "neurotransmitter retention" EXACT [] synonym: "neurotransmitter sequestration" EXACT [] synonym: "neurotransmitter storage" EXACT [] synonym: "retention of neurotransmitter" EXACT [] synonym: "sequestration of neurotransmitter" EXACT [] synonym: "storage of neurotransmitter" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051235 ! maintenance of location [Term] id: GO:0042138 name: meiotic DNA double-strand break formation namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0042139 name: early meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324] is_a: GO:0007146 ! meiotic recombination nodule assembly [Term] id: GO:0042140 name: late meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324] is_a: GO:0007146 ! meiotic recombination nodule assembly [Term] id: GO:0042141 name: obsolete mating pheromone exporter namespace: molecular_function def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl] comment: This term was made obsolete because it is too gene product specific. synonym: "mating pheromone exporter" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0042142 name: obsolete heavy metal chelation namespace: biological_process def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "heavy metal chelation" EXACT [] is_obsolete: true replaced_by: GO:0046911 [Term] id: GO:0042144 name: vacuole fusion, non-autophagic namespace: biological_process alt_id: GO:0042145 def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl] synonym: "homotypic vacuole fusion" EXACT [] synonym: "homotypic vacuole fusion (non-autophagic)" EXACT [] synonym: "homotypic vacuole fusion, non-autophagic" EXACT [] synonym: "vacuole fusion (non-autophagic)" EXACT [] is_a: GO:0097576 ! vacuole fusion [Term] id: GO:0042147 name: retrograde transport, endosome to Golgi namespace: biological_process def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] synonym: "retrograde (endosome to Golgi) transport" EXACT [] is_a: GO:0016197 ! endosomal transport is_a: GO:0016482 ! cytosolic transport [Term] id: GO:0042148 name: strand invasion namespace: biological_process def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855] synonym: "D-loop biosynthesis" RELATED [] synonym: "D-loop formation" RELATED [] synonym: "displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop formation" RELATED [GOC:mah, GOC:vw] synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0042149 name: cellular response to glucose starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0042150 name: plasmid recombination namespace: biological_process def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0042151 name: nematocyst namespace: cellular_component def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl] synonym: "cnidocyst" EXACT [] xref: Wikipedia:Cnidocyte is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0042152 name: RNA-mediated DNA recombination namespace: biological_process def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0042153 name: obsolete RPTP-like protein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT [] synonym: "RPTP-like protein binding" EXACT [] is_obsolete: true replaced_by: GO:0005515 [Term] id: GO:0042156 name: obsolete zinc-mediated transcriptional activator activity namespace: molecular_function def: "OBSOLETE. Initiates or upregulates transcription in the presence of zinc." [GOC:jl] comment: This term was obsoleted because it is defined as a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "zinc-mediated transcriptional activator activity" EXACT [] is_obsolete: true [Term] id: GO:0042157 name: lipoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0042158 name: lipoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein anabolism" EXACT [] synonym: "lipoprotein biosynthesis" EXACT [] synonym: "lipoprotein formation" EXACT [] synonym: "lipoprotein synthesis" EXACT [] is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0042157 ! lipoprotein metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042159 name: lipoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] synonym: "lipoprotein breakdown" EXACT [] synonym: "lipoprotein catabolism" EXACT [] synonym: "lipoprotein degradation" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0042160 name: lipoprotein modification namespace: biological_process def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah] is_a: GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0042161 name: lipoprotein oxidation namespace: biological_process def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah] is_a: GO:0042160 ! lipoprotein modification is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0042162 name: telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] synonym: "telomere binding" EXACT [] synonym: "telomeric repeat binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0042163 name: interleukin-12 beta subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of interleukin-12." [GOC:mah] synonym: "CLMFp40 binding" EXACT [] synonym: "IL-12B binding" EXACT [] synonym: "IL-12p40 binding" EXACT [] synonym: "NKSFp40 binding" EXACT [] is_a: GO:0019972 ! interleukin-12 binding [Term] id: GO:0042164 name: interleukin-12 alpha subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-12." [GOC:mah] synonym: "CLMFp35 binding" EXACT [] synonym: "IL-12A binding" EXACT [] synonym: "IL-12p35 binding" EXACT [] synonym: "NKSFp35 binding" EXACT [] is_a: GO:0019972 ! interleukin-12 binding [Term] id: GO:0042165 name: neurotransmitter binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042166 name: acetylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0008144 ! drug binding is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0042562 ! hormone binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0042167 name: heme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl] synonym: "haem catabolic process" EXACT [] synonym: "haem catabolism" EXACT [] synonym: "heme breakdown" EXACT [] synonym: "heme catabolism" EXACT [] synonym: "heme degradation" EXACT [] is_a: GO:0006787 ! porphyrin-containing compound catabolic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0042168 name: heme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653] synonym: "haem metabolic process" EXACT [] synonym: "haem metabolism" EXACT [] synonym: "heme metabolism" EXACT [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0042169 name: SH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0042170 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0042171 name: lysophosphatidic acid acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050] synonym: "LPAAT activity" EXACT [PMID:16369050] is_a: GO:0071617 ! lysophospholipid acyltransferase activity [Term] id: GO:0042173 name: regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0043937 ! regulation of sporulation is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0042174 name: negative regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators] synonym: "down regulation of sporulation" EXACT [] synonym: "down-regulation of sporulation" EXACT [] synonym: "downregulation of sporulation" EXACT [] synonym: "inhibition of sporulation" NARROW [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030163 ! protein catabolic process relationship: regulates GO:0030163 ! protein catabolic process [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076] synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030163 ! protein catabolic process relationship: negatively_regulates GO:0030163 ! protein catabolic process [Term] id: GO:0042178 name: xenobiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl] synonym: "xenobiotic breakdown" EXACT [] synonym: "xenobiotic catabolism" EXACT [] synonym: "xenobiotic degradation" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042179 name: nicotine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine anabolism" EXACT [] synonym: "nicotine biosynthesis" EXACT [] synonym: "nicotine formation" EXACT [] synonym: "nicotine synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0018933 ! nicotine metabolic process [Term] id: GO:0042180 name: cellular ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir synonym: "ketone metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0042183 name: formate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate breakdown" EXACT [] synonym: "formate catabolism" EXACT [] synonym: "formate degradation" EXACT [] synonym: "formic acid catabolic process" EXACT [] synonym: "formic acid catabolism" EXACT [] is_a: GO:0015942 ! formate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042184 name: xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators] synonym: "xylene breakdown" EXACT [] synonym: "xylene catabolism" EXACT [] synonym: "xylene degradation" EXACT [] is_a: GO:0018948 ! xylene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0042185 name: m-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl] synonym: "m-xylene breakdown" EXACT [] synonym: "m-xylene catabolism" EXACT [] synonym: "m-xylene degradation" EXACT [] synonym: "meta-xylene catabolic process" EXACT [] synonym: "meta-xylene catabolism" EXACT [] xref: MetaCyc:PWY-142 is_a: GO:0018949 ! m-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042186 name: o-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "o-xylene breakdown" EXACT [] synonym: "o-xylene catabolism" EXACT [] synonym: "o-xylene degradation" EXACT [] synonym: "ortho-xylene catabolic process" EXACT [] synonym: "ortho-xylene catabolism" EXACT [] is_a: GO:0018950 ! o-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042187 name: p-xylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "p-xylene breakdown" EXACT [] synonym: "p-xylene catabolism" EXACT [] synonym: "p-xylene degradation" EXACT [] synonym: "para-xylene catabolic process" EXACT [] synonym: "para-xylene catabolism" EXACT [] is_a: GO:0018951 ! p-xylene metabolic process is_a: GO:0042184 ! xylene catabolic process [Term] id: GO:0042188 name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT [] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT [] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT [] synonym: "DDT catabolic process" EXACT [] synonym: "DDT catabolism" EXACT [] is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0042189 name: vanillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] synonym: "vanillic aldehyde biosynthesis" EXACT [] synonym: "vanillic aldehyde biosynthetic process" EXACT [] synonym: "vanillin anabolism" EXACT [] synonym: "vanillin biosynthesis" EXACT [] synonym: "vanillin formation" EXACT [] synonym: "vanillin synthesis" EXACT [] is_a: GO:0018982 ! vanillin metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0042190 name: vanillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] synonym: "vanillic aldehyde catabolic process" EXACT [] synonym: "vanillic aldehyde catabolism" EXACT [] synonym: "vanillin breakdown" EXACT [] synonym: "vanillin catabolism" EXACT [] synonym: "vanillin degradation" EXACT [] is_a: GO:0018982 ! vanillin metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0042191 name: methylmercury metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai] synonym: "methylmercury metabolism" EXACT [] is_a: GO:0018941 ! organomercury metabolic process [Term] id: GO:0042192 name: methylmercury biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] synonym: "methylmercury anabolism" EXACT [] synonym: "methylmercury biosynthesis" EXACT [] synonym: "methylmercury formation" EXACT [] synonym: "methylmercury synthesis" EXACT [] is_a: GO:0042191 ! methylmercury metabolic process is_a: GO:0046414 ! organomercury biosynthetic process [Term] id: GO:0042193 name: methylmercury catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] synonym: "methylmercury breakdown" EXACT [] synonym: "methylmercury catabolism" EXACT [] synonym: "methylmercury degradation" EXACT [] is_a: GO:0042191 ! methylmercury metabolic process is_a: GO:0046413 ! organomercury catabolic process [Term] id: GO:0042194 name: quinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators] synonym: "quinate anabolism" EXACT [] synonym: "quinate biosynthesis" EXACT [] synonym: "quinate formation" EXACT [] synonym: "quinate synthesis" EXACT [] synonym: "quinic acid biosynthesis" EXACT [] synonym: "quinic acid biosynthetic process" EXACT [] is_a: GO:0019630 ! quinate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042195 name: aerobic gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl] synonym: "aerobic gallate breakdown" EXACT [] synonym: "aerobic gallate catabolism" EXACT [] synonym: "aerobic gallate degradation" EXACT [] synonym: "aerobic gallic acid catabolic process" EXACT [] synonym: "aerobic gallic acid catabolism" EXACT [] is_a: GO:0019396 ! gallate catabolic process [Term] id: GO:0042196 name: chlorinated hydrocarbon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] synonym: "chlorinated hydrocarbon metabolism" EXACT [] is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0042197 name: halogenated hydrocarbon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai] synonym: "halogenated hydrocarbon metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0042198 name: nylon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549] synonym: "nylon metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0042199 name: cyanuric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya] synonym: "cyanuric acid metabolism" EXACT [] is_a: GO:0018965 ! s-triazine compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042200 name: cyanuric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [UM-BBD_pathwayID:cya] synonym: "cyanuric acid breakdown" EXACT [] synonym: "cyanuric acid catabolism" EXACT [] synonym: "cyanuric acid degradation" EXACT [] xref: UM-BBD_pathwayID:cya is_a: GO:0042199 ! cyanuric acid metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0042201 name: N-cyclopropylmelamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [UM-BBD_pathwayID:cpm] synonym: "cyromazine metabolic process" EXACT [] synonym: "cyromazine metabolism" EXACT [] synonym: "N-cyclopropylmelamine metabolism" EXACT [] is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0018965 ! s-triazine compound metabolic process [Term] id: GO:0042202 name: N-cyclopropylmelamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [UM-BBD_pathwayID:cpm] synonym: "cyromazine catabolic process" EXACT [] synonym: "cyromazine catabolism" EXACT [] synonym: "N-cyclopropylmelamine breakdown" EXACT [] synonym: "N-cyclopropylmelamine catabolism" EXACT [] synonym: "N-cyclopropylmelamine degradation" EXACT [] xref: UM-BBD_pathwayID:cpm is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0042203 name: toluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators] synonym: "toluene breakdown" EXACT [] synonym: "toluene catabolism" EXACT [] synonym: "toluene degradation" EXACT [] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0042204 name: s-triazine compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria] synonym: "s-triazine compound breakdown" EXACT [] synonym: "s-triazine compound catabolism" EXACT [] synonym: "s-triazine compound degradation" EXACT [] xref: UM-BBD_pathwayID:tria is_a: GO:0018965 ! s-triazine compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042205 name: chlorinated hydrocarbon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] synonym: "chlorinated hydrocarbon breakdown" EXACT [] synonym: "chlorinated hydrocarbon catabolism" EXACT [] synonym: "chlorinated hydrocarbon degradation" EXACT [] is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042206 ! halogenated hydrocarbon catabolic process [Term] id: GO:0042206 name: halogenated hydrocarbon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai] synonym: "halogenated hydrocarbon breakdown" EXACT [] synonym: "halogenated hydrocarbon catabolism" EXACT [] synonym: "halogenated hydrocarbon degradation" EXACT [] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042197 ! halogenated hydrocarbon metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0042207 name: styrene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl] synonym: "styrene breakdown" EXACT [] synonym: "styrene catabolism" EXACT [] synonym: "styrene degradation" EXACT [] xref: UM-BBD_pathwayID:sty is_a: GO:0018966 ! styrene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0042208 name: propylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl] synonym: "propylene breakdown" EXACT [] synonym: "propylene catabolism" EXACT [] synonym: "propylene degradation" EXACT [] xref: UM-BBD_pathwayID:pro is_a: GO:0018964 ! propylene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0042209 name: orcinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl] synonym: "orcin catabolic process" EXACT [] synonym: "orcin catabolism" EXACT [] synonym: "orcinol breakdown" EXACT [] synonym: "orcinol catabolism" EXACT [] synonym: "orcinol degradation" EXACT [] xref: UM-BBD_pathwayID:orc is_a: GO:0018940 ! orcinol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process [Term] id: GO:0042210 name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl] synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT [] synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT [] synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT [] synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018947 ! anaerobic organosilicon metabolic process is_a: GO:0046454 ! dimethylsilanediol metabolic process is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process [Term] id: GO:0042211 name: dimethylsilanediol catabolic process namespace: biological_process def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl] synonym: "catabolic process of DMSD" EXACT [] synonym: "catabolism of DMSD" EXACT [] synonym: "degradation of dimethylsilanediol" EXACT [] synonym: "dimethylsilanediol breakdown" EXACT [] synonym: "dimethylsilanediol catabolism" EXACT [] synonym: "dimethylsilanediol degradation" EXACT [] is_a: GO:0018946 ! aerobic organosilicon metabolic process is_a: GO:0046454 ! dimethylsilanediol metabolic process is_a: GO:0046455 ! organosilicon catabolic process [Term] id: GO:0042212 name: cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [UM-BBD_pathwayID:mcr] synonym: "cresol metabolism" EXACT [] synonym: "hydroxytoluene metabolic process" EXACT [] synonym: "hydroxytoluene metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0042213 name: m-cresol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl] synonym: "3-hydroxytoluene catabolic process" EXACT [] synonym: "3-hydroxytoluene catabolism" EXACT [] synonym: "m-cresol breakdown" EXACT [] synonym: "m-cresol catabolism" EXACT [] synonym: "m-cresol degradation" EXACT [] synonym: "meta-cresol catabolic process" EXACT [] synonym: "meta-cresol catabolism" EXACT [] xref: MetaCyc:M-CRESOL-DEGRADATION-PWY xref: UM-BBD_pathwayID:mcr is_a: GO:0018925 ! m-cresol metabolic process is_a: GO:0046199 ! cresol catabolic process [Term] id: GO:0042214 name: terpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [GOC:curators] synonym: "terpene metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0042215 name: anaerobic phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [PMID:12697029] synonym: "anaerobic phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0042216 name: phenanthrene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl] synonym: "phenanthrene breakdown" EXACT [] synonym: "phenanthrene catabolism" EXACT [] synonym: "phenanthrene degradation" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0018955 ! phenanthrene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0042217 name: 1-aminocyclopropane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT [] is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0042218 name: 1-aminocyclopropane-1-carboxylate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT [] synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT [] is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0042219 name: cellular modified amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative catabolic process" EXACT [] synonym: "cellular amino acid derivative breakdown" EXACT [] synonym: "cellular amino acid derivative catabolic process" EXACT [] synonym: "cellular amino acid derivative catabolism" EXACT [] synonym: "cellular amino acid derivative degradation" EXACT [] synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah] synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid degradation" EXACT [GOC:mah] synonym: "modified amino acid catabolic process" EXACT [GOC:mah] synonym: "modified amino acid catabolism" EXACT [GOC:mah] is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042220 name: response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:0060359 ! response to ammonium ion is_a: GO:0072347 ! response to anesthetic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] xref: MIPS_funcat:34.11.03 xref: MIPS_funcat:34.11.03.05 xref: MIPS_funcat:36.20.35.09 is_a: GO:0050896 ! response to stimulus [Term] id: GO:0042222 name: interleukin-1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732] synonym: "IL-1 biosynthesis" EXACT [] synonym: "IL-1 biosynthetic process" EXACT [] synonym: "interleukin-1 anabolism" EXACT [] synonym: "interleukin-1 biosynthesis" EXACT [] synonym: "interleukin-1 formation" EXACT [] synonym: "interleukin-1 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032612 ! interleukin-1 production [Term] id: GO:0042223 name: interleukin-3 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "IL-3 biosynthesis" EXACT [] synonym: "IL-3 biosynthetic process" EXACT [] synonym: "interleukin-3 anabolism" EXACT [] synonym: "interleukin-3 biosynthesis" EXACT [] synonym: "interleukin-3 formation" EXACT [] synonym: "interleukin-3 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032632 ! interleukin-3 production [Term] id: GO:0042225 name: interleukin-5 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "IL-5 biosynthesis" EXACT [] synonym: "IL-5 biosynthetic process" EXACT [] synonym: "interleukin-5 anabolism" EXACT [] synonym: "interleukin-5 biosynthesis" EXACT [] synonym: "interleukin-5 formation" EXACT [] synonym: "interleukin-5 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032634 ! interleukin-5 production [Term] id: GO:0042226 name: interleukin-6 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "IL-6 biosynthesis" EXACT [] synonym: "IL-6 biosynthetic process" EXACT [] synonym: "interleukin-6 anabolism" EXACT [] synonym: "interleukin-6 biosynthesis" EXACT [] synonym: "interleukin-6 formation" EXACT [] synonym: "interleukin-6 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032635 ! interleukin-6 production [Term] id: GO:0042227 name: interleukin-7 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "IL-7 biosynthesis" EXACT [] synonym: "IL-7 biosynthetic process" EXACT [] synonym: "interleukin-7 anabolism" EXACT [] synonym: "interleukin-7 biosynthesis" EXACT [] synonym: "interleukin-7 formation" EXACT [] synonym: "interleukin-7 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032636 ! interleukin-7 production [Term] id: GO:0042228 name: interleukin-8 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "IL-8 biosynthesis" EXACT [] synonym: "IL-8 biosynthetic process" EXACT [] synonym: "interleukin-8 anabolism" EXACT [] synonym: "interleukin-8 biosynthesis" EXACT [] synonym: "interleukin-8 formation" EXACT [] synonym: "interleukin-8 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032637 ! interleukin-8 production [Term] id: GO:0042229 name: interleukin-9 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "IL-9 biosynthesis" EXACT [] synonym: "IL-9 biosynthetic process" EXACT [] synonym: "interleukin-9 anabolism" EXACT [] synonym: "interleukin-9 biosynthesis" EXACT [] synonym: "interleukin-9 formation" EXACT [] synonym: "interleukin-9 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032638 ! interleukin-9 production [Term] id: GO:0042230 name: interleukin-11 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "IL-11 biosynthesis" EXACT [] synonym: "IL-11 biosynthetic process" EXACT [] synonym: "interleukin-11 anabolism" EXACT [] synonym: "interleukin-11 biosynthesis" EXACT [] synonym: "interleukin-11 formation" EXACT [] synonym: "interleukin-11 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032614 ! interleukin-11 production [Term] id: GO:0042231 name: interleukin-13 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "IL-13 biosynthesis" EXACT [] synonym: "IL-13 biosynthetic process" EXACT [] synonym: "interleukin-13 anabolism" EXACT [] synonym: "interleukin-13 biosynthesis" EXACT [] synonym: "interleukin-13 formation" EXACT [] synonym: "interleukin-13 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032616 ! interleukin-13 production [Term] id: GO:0042232 name: interleukin-14 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "IL-14 biosynthesis" EXACT [] synonym: "IL-14 biosynthetic process" EXACT [] synonym: "interleukin-14 anabolism" EXACT [] synonym: "interleukin-14 biosynthesis" EXACT [] synonym: "interleukin-14 formation" EXACT [] synonym: "interleukin-14 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032617 ! interleukin-14 production [Term] id: GO:0042233 name: interleukin-15 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "IL-15 biosynthesis" EXACT [] synonym: "IL-15 biosynthetic process" EXACT [] synonym: "interleukin-15 anabolism" EXACT [] synonym: "interleukin-15 biosynthesis" EXACT [] synonym: "interleukin-15 formation" EXACT [] synonym: "interleukin-15 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032618 ! interleukin-15 production [Term] id: GO:0042234 name: interleukin-16 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "IL-16 biosynthesis" EXACT [] synonym: "IL-16 biosynthetic process" EXACT [] synonym: "interleukin-16 anabolism" EXACT [] synonym: "interleukin-16 biosynthesis" EXACT [] synonym: "interleukin-16 formation" EXACT [] synonym: "interleukin-16 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032619 ! interleukin-16 production [Term] id: GO:0042235 name: interleukin-17 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] synonym: "IL-17 biosynthesis" EXACT [] synonym: "IL-17 biosynthetic process" EXACT [] synonym: "interleukin-17 anabolism" EXACT [] synonym: "interleukin-17 biosynthesis" EXACT [] synonym: "interleukin-17 formation" EXACT [] synonym: "interleukin-17 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032620 ! interleukin-17 production [Term] id: GO:0042236 name: interleukin-19 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "IL-19 biosynthesis" EXACT [] synonym: "IL-19 biosynthetic process" EXACT [] synonym: "interleukin-19 anabolism" EXACT [] synonym: "interleukin-19 biosynthesis" EXACT [] synonym: "interleukin-19 formation" EXACT [] synonym: "interleukin-19 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032622 ! interleukin-19 production [Term] id: GO:0042237 name: interleukin-20 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "IL-20 biosynthesis" EXACT [] synonym: "IL-20 biosynthetic process" EXACT [] synonym: "interleukin-20 anabolism" EXACT [] synonym: "interleukin-20 biosynthesis" EXACT [] synonym: "interleukin-20 formation" EXACT [] synonym: "interleukin-20 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032624 ! interleukin-20 production [Term] id: GO:0042238 name: interleukin-21 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "IL-21 biosynthesis" EXACT [] synonym: "IL-21 biosynthetic process" EXACT [] synonym: "interleukin-21 anabolism" EXACT [] synonym: "interleukin-21 biosynthesis" EXACT [] synonym: "interleukin-21 formation" EXACT [] synonym: "interleukin-21 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032625 ! interleukin-21 production [Term] id: GO:0042239 name: interleukin-22 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "IL-22 biosynthesis" EXACT [] synonym: "IL-22 biosynthetic process" EXACT [] synonym: "interleukin-22 anabolism" EXACT [] synonym: "interleukin-22 biosynthesis" EXACT [] synonym: "interleukin-22 formation" EXACT [] synonym: "interleukin-22 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032626 ! interleukin-22 production [Term] id: GO:0042240 name: interleukin-23 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "IL-23 biosynthesis" EXACT [] synonym: "IL-23 biosynthetic process" EXACT [] synonym: "interleukin-23 anabolism" EXACT [] synonym: "interleukin-23 biosynthesis" EXACT [] synonym: "interleukin-23 formation" EXACT [] synonym: "interleukin-23 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032627 ! interleukin-23 production [Term] id: GO:0042241 name: interleukin-18 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "IL-18 biosynthesis" EXACT [] synonym: "IL-18 biosynthetic process" EXACT [] synonym: "interleukin-18 anabolism" EXACT [] synonym: "interleukin-18 biosynthesis" EXACT [] synonym: "interleukin-18 formation" EXACT [] synonym: "interleukin-18 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032621 ! interleukin-18 production [Term] id: GO:0042242 name: cobyrinic acid a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [EC:6.3.5.11, PMID:2172209] synonym: "CobB" NARROW [] xref: EC:6.3.5.11 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0042243 name: asexual spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species." [GOC:mah] synonym: "asexual spore wall formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly relationship: part_of GO:0030436 ! asexual sporulation [Term] id: GO:0042244 name: spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat biosynthesis" EXACT [] synonym: "spore coat biosynthetic process" EXACT [] synonym: "spore wall formation" EXACT [] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0070590 ! spore wall biogenesis [Term] id: GO:0042245 name: RNA repair namespace: biological_process def: "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0042246 name: tissue regeneration namespace: biological_process def: "The regrowth of lost or destroyed tissues." [GOC:curators] is_a: GO:0009888 ! tissue development is_a: GO:0031099 ! regeneration is_a: GO:0048589 ! developmental growth relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0042247 name: establishment of planar polarity of follicular epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium [Term] id: GO:0042248 name: maintenance of polarity of follicular epithelium namespace: biological_process def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf] is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium [Term] id: GO:0042249 name: establishment of planar polarity of embryonic epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0042250 name: maintenance of polarity of embryonic epithelium namespace: biological_process def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl] is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium [Term] id: GO:0042251 name: maintenance of polarity of larval imaginal disc epithelium namespace: biological_process def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl] is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium [Term] id: GO:0042252 name: establishment of planar polarity of larval imaginal disc epithelium namespace: biological_process def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0042253 name: granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732] synonym: "GM-CSF biosynthesis" EXACT [] synonym: "GM-CSF biosynthetic process" EXACT [] synonym: "GMC-SF biosynthesis" EXACT [] synonym: "GMC-SF biosynthetic process" EXACT [] synonym: "granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0042255 name: ribosome assembly namespace: biological_process alt_id: GO:0042257 def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma] subset: goslim_yeast synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042256 name: mature ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] is_a: GO:0042255 ! ribosome assembly [Term] id: GO:0042258 name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319] xref: RESID:AA0319 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0042259 name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine namespace: biological_process def: "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320] synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT [] synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT [] synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT [] xref: RESID:AA0320 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0042262 name: DNA protection namespace: biological_process def: "Any process in which DNA is protected from damage by, for example, oxidative stress." [GOC:jl] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0042263 name: neuropeptide F receptor activity namespace: molecular_function def: "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021] comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. synonym: "NPF receptor activity" EXACT [PMID:21440021] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0042264 name: peptidyl-aspartic acid hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah] synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0042265 name: peptidyl-asparagine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah] synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0042267 name: natural killer cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "killer activity" RELATED [] synonym: "natural killer cell mediated cell death" EXACT [] synonym: "natural killer cell mediated cell killing" EXACT [] synonym: "natural killer cell mediated cytolysis" RELATED [] synonym: "natural killer-cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cell death" EXACT [] synonym: "NK cell mediated cell killing" EXACT [] synonym: "NK cell mediated cytolysis" RELATED [] synonym: "NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0042268 name: regulation of cytolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019835 ! cytolysis relationship: regulates GO:0019835 ! cytolysis [Term] id: GO:0042269 name: regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of natural killer cell mediated cell death" EXACT [] synonym: "regulation of natural killer cell mediated cell killing" EXACT [] synonym: "regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "regulation of natural killer-cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cell death" EXACT [] synonym: "regulation of NK cell mediated cell killing" EXACT [] synonym: "regulation of NK cell mediated cytolysis" RELATED [] synonym: "regulation of NK cell mediated cytotoxicity" RELATED [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042267 ! natural killer cell mediated cytotoxicity relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0042270 name: protection from natural killer cell mediated cytotoxicity namespace: biological_process def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "protection from natural killer cell mediated cell death" EXACT [] synonym: "protection from natural killer cell mediated cell killing" EXACT [] synonym: "protection from natural killer cell mediated cytolysis" RELATED [] synonym: "protection from NK cell mediated cell death" EXACT [] synonym: "protection from NK cell mediated cell killing" EXACT [] synonym: "protection from NK cell mediated cytolysis" RELATED [] synonym: "protection from NK cell mediated cytotoxicity" EXACT [] is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity [Term] id: GO:0042271 name: susceptibility to natural killer cell mediated cytotoxicity namespace: biological_process def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity. synonym: "susceptibility to natural killer cell mediated cell death" EXACT [] synonym: "susceptibility to natural killer cell mediated cell killing" EXACT [] synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED [] synonym: "susceptibility to NK cell mediated cell death" EXACT [] synonym: "susceptibility to NK cell mediated cell killing" EXACT [] synonym: "susceptibility to NK cell mediated cytolysis" EXACT [] synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT [] is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity [Term] id: GO:0042272 name: nuclear RNA export factor complex namespace: cellular_component def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633] synonym: "Mex67-Mtr2 complex" EXACT [] synonym: "NXF1-NXT1 complex" EXACT [] synonym: "TAP-p15 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0042273 name: ribosomal large subunit biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] subset: goslim_yeast synonym: "ribosomal large subunit biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042274 name: ribosomal small subunit biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] subset: goslim_yeast synonym: "ribosomal small subunit biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0042275 name: error-free postreplication DNA repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630] comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. synonym: "error-free PRR" EXACT [] synonym: "error-free replication restart" RELATED [] is_a: GO:0006301 ! postreplication repair [Term] id: GO:0042276 name: error-prone translesion synthesis namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998] synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic PRR" EXACT [] is_a: GO:0019985 ! translesion synthesis [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir xref: MIPS_funcat:16.02 is_a: GO:0033218 ! amide binding [Term] id: GO:0042278 name: purine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "purine metabolic process" BROAD [] synonym: "purine metabolism" BROAD [] synonym: "purine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0042279 name: nitrite reductase (cytochrome, ammonia-forming) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2] synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2] synonym: "cytochrome c nitrite reductase activity" EXACT [] synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2] synonym: "multiheme nitrite reductase activity" EXACT [] synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2] xref: EC:1.7.2.2 xref: MetaCyc:1.7.2.2-RXN xref: Wikipedia:Cytochrome_c_nitrite_reductase is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor is_a: GO:0098809 ! nitrite reductase activity [Term] id: GO:0042280 name: obsolete cell surface antigen activity, host-interacting namespace: molecular_function def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "cell surface antigen activity, host-interacting" EXACT [] is_obsolete: true consider: GO:0044403 consider: GO:0046789 [Term] id: GO:0042281 name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470] synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: MetaCyc:RXN-5470 is_a: GO:0046527 ! glucosyltransferase activity relationship: part_of GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process [Term] id: GO:0042282 name: hydroxymethylglutaryl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH." [EC:1.1.1.88, RHEA:14833] synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88] xref: EC:1.1.1.88 xref: KEGG_REACTION:R02081 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN xref: RHEA:14833 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0042283 name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927] synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: MetaCyc:RXN-5471 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0042284 name: sphingolipid delta-4 desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141] synonym: "delta-4 sphingolipid desaturase activity" EXACT [] xref: Reactome:R-HSA-428259 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0042285 name: xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0042286 name: glutamate-1-semialdehyde 2,1-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8, RHEA:14265] synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8] synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8] xref: EC:5.4.3.8 xref: KEGG_REACTION:R02272 xref: MetaCyc:GSAAMINOTRANS-RXN xref: RHEA:14265 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0042287 name: MHC protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex binding" EXACT [] synonym: "major histocompatibility complex ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042288 name: MHC class I protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "major histocompatibility complex class I binding" EXACT [] synonym: "major histocompatibility complex class I ligand" NARROW [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0042289 name: MHC class II protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. synonym: "major histocompatibility complex class II binding" EXACT [] synonym: "major histocompatibility complex class II ligand" NARROW [] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0042290 name: obsolete URM1 hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "URM1 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0042291 name: obsolete Hub1 hydrolase activity namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "Hub1 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0042292 name: URM1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0042293 name: Hub1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0042294 name: URM1 transferase activity namespace: molecular_function def: "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages." [GOC:mah, PMID:12826404] is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0042296 name: ISG15 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "ISG15 conjugating enzyme activity" NARROW [] xref: Reactome:R-HSA-5653754 "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0042297 name: vocal learning namespace: biological_process def: "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] comment: Examples include language learning by human infants and song learning in zebra finches. xref: Wikipedia:Vocal_learning is_a: GO:0031223 ! auditory behavior is_a: GO:0098596 ! imitative learning is_a: GO:0098598 ! learned vocalization behavior or vocal learning [Term] id: GO:0042299 name: lupeol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589] synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99 xref: MetaCyc:RXN-111 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042300 name: beta-amyrin synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin." [PMID:9746369] synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99 xref: MetaCyc:RXN-7570 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042301 name: phosphate ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphate." [GOC:jl] is_a: GO:0043168 ! anion binding [Term] id: GO:0042302 name: structural constituent of cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] subset: goslim_drosophila is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0042303 name: molting cycle namespace: biological_process def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0042304 name: regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] synonym: "regulation of fatty acid anabolism" EXACT [] synonym: "regulation of fatty acid biosynthesis" EXACT [] synonym: "regulation of fatty acid formation" EXACT [] synonym: "regulation of fatty acid synthesis" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006633 ! fatty acid biosynthetic process relationship: regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042305 name: specification of segmental identity, mandibular segment namespace: biological_process def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0042306 name: regulation of protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] synonym: "regulation of protein import into cell nucleus" EXACT [] synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of protein-nucleus import" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1904589 ! regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006606 ! protein import into nucleus relationship: regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042307 name: positive regulation of protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "activation of protein import into nucleus" NARROW [] synonym: "positive regulation of protein import into cell nucleus" EXACT [] synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of protein-nucleus import" EXACT [] synonym: "stimulation of protein import into nucleus" NARROW [] synonym: "up regulation of protein import into nucleus" EXACT [] synonym: "up-regulation of protein import into nucleus" EXACT [] synonym: "upregulation of protein import into nucleus" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904591 ! positive regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006606 ! protein import into nucleus relationship: positively_regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042308 name: negative regulation of protein import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "down regulation of protein import into nucleus" EXACT [] synonym: "down-regulation of protein import into nucleus" EXACT [] synonym: "downregulation of protein import into nucleus" EXACT [] synonym: "inhibition of protein import into nucleus" NARROW [] synonym: "negative regulation of protein import into cell nucleus" EXACT [] synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of protein-nucleus import" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904590 ! negative regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006606 ! protein import into nucleus relationship: negatively_regulates GO:0006606 ! protein import into nucleus [Term] id: GO:0042309 name: homoiothermy namespace: biological_process def: "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023] synonym: "antifreeze activity" RELATED [] synonym: "ice nucleation activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0042310 name: vasoconstriction namespace: biological_process def: "A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure." [GOC:pr, ISBN:0192800752] synonym: "negative regulation of blood vessel size" EXACT [] xref: Wikipedia:Vasoconstriction is_a: GO:0097756 ! negative regulation of blood vessel diameter [Term] id: GO:0042311 name: vasodilation namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure." [GOC:pr, ISBN:0192800981] synonym: "positive regulation of blood vessel size" EXACT [] synonym: "vasodilatation" EXACT [] xref: Wikipedia:Vasodilation is_a: GO:0097755 ! positive regulation of blood vessel diameter [Term] id: GO:0042313 name: protein kinase C deactivation namespace: biological_process def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf] synonym: "PKC deactivation" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway [Term] id: GO:0042314 name: bacteriochlorophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981] is_a: GO:0016168 ! chlorophyll binding [Term] id: GO:0042315 name: obsolete cytosol nonspecific dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18] comment: This term was made obsolete because it represents a gene product. synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "cytosol nonspecific dipeptidase activity" EXACT [] synonym: "diglycinase activity" EXACT [EC:3.4.13.18] synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18] synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18] synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18] synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18] synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18] synonym: "peptidase A activity" BROAD [EC:3.4.13.18] synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolinase activity" NARROW [EC:3.4.13.18] synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] xref: EC:3.4.13.18 xref: MetaCyc:3.4.13.18-RXN is_obsolete: true replaced_by: GO:0016805 [Term] id: GO:0042316 name: penicillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732] synonym: "penicillin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0042317 name: penicillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732] synonym: "penicillin breakdown" EXACT [] synonym: "penicillin catabolism" EXACT [] synonym: "penicillin degradation" EXACT [] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process is_a: GO:0042316 ! penicillin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process [Term] id: GO:0042318 name: penicillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732] synonym: "penicillin anabolism" EXACT [] synonym: "penicillin biosynthesis" EXACT [] synonym: "penicillin formation" EXACT [] synonym: "penicillin synthesis" EXACT [] is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:0042316 ! penicillin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0042320 name: regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998] synonym: "regulation of REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042321 name: negative regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981] synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW [] synonym: "negative regulation of sleep" EXACT [] is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042322 name: negative regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "negative regulation of REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0042323 name: negative regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl] synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "negative regulation of non-REM sleep" EXACT [] is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0042324 name: hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hypocretin receptor." [GOC:ceb, PMID:11988773] synonym: "hypocretin receptor ligand" NARROW [] synonym: "orexin receptor binding" EXACT [] synonym: "orexin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016310 ! phosphorylation relationship: regulates GO:0016310 ! phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016310 ! phosphorylation relationship: negatively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016310 ! phosphorylation relationship: positively_regulates GO:0016310 ! phosphorylation [Term] id: GO:0042328 name: heparan sulfate N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma] synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT [] synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED [] is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0042329 name: structural constituent of collagen and cuticulin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] synonym: "structural constituent of cuticle" BROAD [] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0040011 ! locomotion relationship: part_of GO:0009605 ! response to external stimulus [Term] id: GO:0042331 name: phototaxis namespace: biological_process alt_id: GO:0046953 def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] synonym: "phototactic behavior" EXACT [] synonym: "phototactic behaviour" EXACT [] synonym: "taxis in response to light" EXACT [] xref: MIPS_funcat:34.11.01.05 xref: Wikipedia:Phototaxis is_a: GO:0009416 ! response to light stimulus is_a: GO:0009453 ! energy taxis [Term] id: GO:0042332 name: gravitaxis namespace: biological_process alt_id: GO:0048062 def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] synonym: "geotactic behavior" EXACT [] synonym: "geotactic behaviour" EXACT [] synonym: "geotaxis" EXACT [] synonym: "gravitactic behavior" EXACT [] synonym: "gravitactic behaviour" EXACT [] synonym: "taxis in response to gravitational stimulus" EXACT [] synonym: "taxis in response to gravity" EXACT [] is_a: GO:0009629 ! response to gravity is_a: GO:0042330 ! taxis [Term] id: GO:0042333 name: chemotaxis to oxidizable substrate namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423] synonym: "taxis in response to oxidizable substrate" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0042334 name: taxis to electron acceptor namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423] synonym: "taxis in response to electron acceptor" EXACT [] is_a: GO:0009453 ! energy taxis [Term] id: GO:0042335 name: cuticle development namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825] subset: goslim_drosophila synonym: "cuticle anabolism" EXACT [] synonym: "cuticle biosynthesis" EXACT [] synonym: "cuticle biosynthetic process" EXACT [] synonym: "cuticle formation" EXACT [] synonym: "cuticle synthesis" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0042336 name: obsolete cuticle development involved in protein-based cuticle molting cycle namespace: biological_process def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle development involved in protein-based cuticle molting cycle" EXACT [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_obsolete: true consider: GO:0042337 consider: GO:0042338 [Term] id: GO:0042337 name: cuticle development involved in chitin-based cuticle molting cycle namespace: biological_process def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb] synonym: "chitin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development intersection_of: GO:0042335 ! cuticle development intersection_of: part_of GO:0007591 ! molting cycle, chitin-based cuticle relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0042338 name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle namespace: biological_process def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] synonym: "cuticle anabolism during molting" BROAD [] synonym: "cuticle biosynthetic process during molting" BROAD [] synonym: "cuticle formation during molting" BROAD [] synonym: "cuticle synthesis during molting" BROAD [] is_a: GO:0040002 ! collagen and cuticulin-based cuticle development intersection_of: GO:0042335 ! cuticle development intersection_of: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0042339 name: keratan sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] synonym: "keratan sulfate metabolism" EXACT [] synonym: "keratan sulphate metabolic process" EXACT [] synonym: "keratan sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0042340 name: keratan sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] synonym: "keratan sulfate breakdown" EXACT [] synonym: "keratan sulfate catabolism" EXACT [] synonym: "keratan sulfate degradation" EXACT [] synonym: "keratan sulphate catabolic process" EXACT [] synonym: "keratan sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0042339 ! keratan sulfate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0042341 name: cyanogenic glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] synonym: "cyanogenic glycoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0042342 name: cyanogenic glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] synonym: "cyanogenic glycoside breakdown" EXACT [] synonym: "cyanogenic glycoside catabolism" EXACT [] synonym: "cyanogenic glycoside degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0042341 ! cyanogenic glycoside metabolic process is_a: GO:0050899 ! nitrile catabolic process [Term] id: GO:0042343 name: indole glucosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [GOC:curators] synonym: "indole glucosinolate metabolism" EXACT [] is_a: GO:0019760 ! glucosinolate metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0042344 name: indole glucosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com] synonym: "indole glucosinolate breakdown" EXACT [] synonym: "indole glucosinolate catabolism" EXACT [] synonym: "indole glucosinolate degradation" EXACT [] is_a: GO:0019762 ! glucosinolate catabolic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0042349 name: guiding stereospecific synthesis activity namespace: molecular_function def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma] synonym: "dirigent protein" NARROW [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0042350 name: GDP-L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl] synonym: "GDP-L-fucose anabolism" EXACT [] synonym: "GDP-L-fucose biosynthesis" EXACT [] synonym: "GDP-L-fucose formation" EXACT [] synonym: "GDP-L-fucose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046368 ! GDP-L-fucose metabolic process [Term] id: GO:0042351 name: 'de novo' GDP-L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750] synonym: "'de novo' GDP-L-fucose anabolism" EXACT [] synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT [] synonym: "'de novo' GDP-L-fucose formation" EXACT [] synonym: "'de novo' GDP-L-fucose synthesis" EXACT [] synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT [] synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT [] xref: MetaCyc:PWY-66 is_a: GO:0042350 ! GDP-L-fucose biosynthetic process [Term] id: GO:0042352 name: GDP-L-fucose salvage namespace: biological_process def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma] synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT [] synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT [] xref: MetaCyc:PWY-6 is_a: GO:0042350 ! GDP-L-fucose biosynthetic process is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0042353 name: fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl] synonym: "fucose anabolism" EXACT [] synonym: "fucose biosynthesis" EXACT [] synonym: "fucose formation" EXACT [] synonym: "fucose synthesis" EXACT [] is_a: GO:0006004 ! fucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0042354 name: L-fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732] synonym: "L-fucose metabolism" EXACT [] is_a: GO:0006004 ! fucose metabolic process [Term] id: GO:0042355 name: L-fucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl] synonym: "L-fucose breakdown" EXACT [] synonym: "L-fucose catabolism" EXACT [] synonym: "L-fucose degradation" EXACT [] is_a: GO:0019317 ! fucose catabolic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0042356 name: GDP-4-dehydro-D-rhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187] synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187] synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] xref: EC:1.1.1.187 xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0042357 name: thiamine diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] synonym: "thiamin diphosphate metabolic process" EXACT [] synonym: "thiamin diphosphate metabolism" EXACT [] synonym: "thiamin pyrophosphate metabolic process" EXACT [] synonym: "thiamin pyrophosphate metabolism" EXACT [] synonym: "thiamine diphosphate metabolism" EXACT [] synonym: "thiamine pyrophosphate metabolic process" EXACT [] synonym: "thiamine pyrophosphate metabolism" EXACT [] synonym: "TPP metabolic process" EXACT [] synonym: "TPP metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0042358 name: thiamine diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] synonym: "thiamin diphosphate breakdown" EXACT [] synonym: "thiamin diphosphate catabolic process" EXACT [] synonym: "thiamin diphosphate catabolism" EXACT [] synonym: "thiamin diphosphate degradation" EXACT [] synonym: "thiamin pyrophosphate catabolic process" EXACT [] synonym: "thiamin pyrophosphate catabolism" EXACT [] synonym: "thiamine diphosphate catabolism" EXACT [] synonym: "thiamine pyrophosphate catabolic process" EXACT [] synonym: "thiamine pyrophosphate catabolism" EXACT [] synonym: "TPP catabolic process" EXACT [] synonym: "TPP catabolism" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0042359 name: vitamin D metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] synonym: "calciferol metabolic process" NARROW [] synonym: "calciferol metabolism" NARROW [] synonym: "cholecalciferol metabolic process" NARROW [] synonym: "cholecalciferol metabolism" NARROW [] synonym: "ergocalciferol metabolic process" NARROW [] synonym: "ergocalciferol metabolism" NARROW [] synonym: "vitamin D metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0008202 ! steroid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042360 name: vitamin E metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732] synonym: "alpha-tocopherol metabolic process" NARROW [] synonym: "alpha-tocopherol metabolism" NARROW [] synonym: "tocopherol metabolic process" EXACT [] synonym: "tocopherol metabolism" EXACT [] synonym: "vitamin E metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042361 name: menaquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "menaquinone breakdown" EXACT [] synonym: "menaquinone catabolism" EXACT [] synonym: "menaquinone degradation" EXACT [] synonym: "menatetrenone catabolic process" EXACT [] synonym: "menatetrenone catabolism" EXACT [] synonym: "multiprenylmenaquinone catabolic process" EXACT [] synonym: "multiprenylmenaquinone catabolism" EXACT [] synonym: "vitamin K2 catabolic process" EXACT [] synonym: "vitamin K2 catabolism" EXACT [] is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:1901662 ! quinone catabolic process [Term] id: GO:0042362 name: fat-soluble vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] synonym: "fat-soluble vitamin anabolism" EXACT [] synonym: "fat-soluble vitamin biosynthesis" EXACT [] synonym: "fat-soluble vitamin formation" EXACT [] synonym: "fat-soluble vitamin synthesis" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0009110 ! vitamin biosynthetic process [Term] id: GO:0042363 name: fat-soluble vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] synonym: "fat-soluble vitamin breakdown" EXACT [] synonym: "fat-soluble vitamin catabolism" EXACT [] synonym: "fat-soluble vitamin degradation" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process is_a: GO:0009111 ! vitamin catabolic process [Term] id: GO:0042364 name: water-soluble vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl] synonym: "water-soluble vitamin anabolism" EXACT [] synonym: "water-soluble vitamin biosynthesis" EXACT [] synonym: "water-soluble vitamin formation" EXACT [] synonym: "water-soluble vitamin synthesis" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009110 ! vitamin biosynthetic process [Term] id: GO:0042365 name: water-soluble vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "water-soluble vitamin breakdown" EXACT [] synonym: "water-soluble vitamin catabolism" EXACT [] synonym: "water-soluble vitamin degradation" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009111 ! vitamin catabolic process [Term] id: GO:0042366 name: cobalamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] synonym: "cobalamin breakdown" EXACT [] synonym: "cobalamin catabolism" EXACT [] synonym: "cobalamin degradation" EXACT [] synonym: "vitamin B12 catabolic process" EXACT [] synonym: "vitamin B12 catabolism" EXACT [] is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0042367 name: biotin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] synonym: "biotin breakdown" EXACT [] synonym: "biotin catabolism" EXACT [] synonym: "biotin degradation" EXACT [] synonym: "vitamin B7 catabolic process" EXACT [] synonym: "vitamin B7 catabolism" EXACT [] synonym: "vitamin H catabolic process" EXACT [] synonym: "vitamin H catabolism" EXACT [] is_a: GO:0006768 ! biotin metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042368 name: vitamin D biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] synonym: "calciferol biosynthesis" NARROW [] synonym: "calciferol biosynthetic process" NARROW [] synonym: "cholecalciferol biosynthesis" NARROW [] synonym: "cholecalciferol biosynthetic process" NARROW [] synonym: "ergocalciferol biosynthesis" NARROW [] synonym: "ergocalciferol biosynthetic process" NARROW [] synonym: "vitamin D anabolism" EXACT [] synonym: "vitamin D biosynthesis" EXACT [] synonym: "vitamin D formation" EXACT [] synonym: "vitamin D synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042359 ! vitamin D metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042369 name: vitamin D catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] synonym: "calciferol catabolic process" NARROW [] synonym: "calciferol catabolism" NARROW [] synonym: "cholecalciferol biosynthesis" NARROW [] synonym: "cholecalciferol biosynthetic process" NARROW [] synonym: "ergocalciferol biosynthesis" NARROW [] synonym: "ergocalciferol biosynthetic process" NARROW [] synonym: "vitamin D breakdown" EXACT [] synonym: "vitamin D catabolism" EXACT [] synonym: "vitamin D degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042359 ! vitamin D metabolic process is_a: GO:0042363 ! fat-soluble vitamin catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0042370 name: thiamine diphosphate dephosphorylation namespace: biological_process def: "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] synonym: "thiamin diphosphate dephosphorylation" EXACT [] synonym: "TPP dephosphorylation" EXACT [] is_a: GO:0042357 ! thiamine diphosphate metabolic process [Term] id: GO:0042371 name: vitamin K biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "naphthoquinone metabolic process" BROAD [] synonym: "naphthoquinone metabolism" BROAD [] synonym: "vitamin K anabolism" EXACT [] synonym: "vitamin K biosynthesis" EXACT [] synonym: "vitamin K formation" EXACT [] synonym: "vitamin K synthesis" EXACT [] xref: MIPS_funcat:01.20.15.01 is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process is_a: GO:0042373 ! vitamin K metabolic process [Term] id: GO:0042372 name: phylloquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "phylloquinone anabolism" EXACT [] synonym: "phylloquinone biosynthesis" EXACT [] synonym: "phylloquinone formation" EXACT [] synonym: "phylloquinone synthesis" EXACT [] synonym: "phytomenadione biosynthesis" EXACT [] synonym: "phytomenadione biosynthetic process" EXACT [] synonym: "phytonadione biosynthesis" EXACT [] synonym: "phytonadione biosynthetic process" EXACT [] synonym: "phytylmenaquinone biosynthesis" EXACT [] synonym: "phytylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K1 biosynthesis" EXACT [] synonym: "vitamin K1 biosynthetic process" EXACT [] xref: MetaCyc:PWY-5027 is_a: GO:0009110 ! vitamin biosynthetic process is_a: GO:0042374 ! phylloquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0042373 name: vitamin K metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "naphthoquinone metabolic process" BROAD [] synonym: "naphthoquinone metabolism" BROAD [] synonym: "vitamin K metabolism" EXACT [] is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0042374 name: phylloquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "phylloquinone metabolism" EXACT [] synonym: "phytomenadione metabolic process" EXACT [] synonym: "phytomenadione metabolism" EXACT [] synonym: "phytonadione metabolic process" EXACT [] synonym: "phytonadione metabolism" EXACT [] synonym: "phytylmenaquinone metabolic process" EXACT [] synonym: "phytylmenaquinone metabolism" EXACT [] synonym: "vitamin K1 metabolic process" EXACT [] synonym: "vitamin K1 metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:1901661 ! quinone metabolic process [Term] id: GO:0042376 name: phylloquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "phylloquinone breakdown" EXACT [] synonym: "phylloquinone catabolism" EXACT [] synonym: "phylloquinone degradation" EXACT [] synonym: "phytomenadione catabolic process" EXACT [] synonym: "phytomenadione catabolism" EXACT [] synonym: "phytonadione catabolic process" EXACT [] synonym: "phytonadione catabolism" EXACT [] synonym: "phytylmenaquinone catabolic process" EXACT [] synonym: "phytylmenaquinone catabolism" EXACT [] synonym: "vitamin K1 catabolic process" EXACT [] synonym: "vitamin K1 catabolism" EXACT [] is_a: GO:0009111 ! vitamin catabolic process is_a: GO:0042374 ! phylloquinone metabolic process is_a: GO:1901662 ! quinone catabolic process [Term] id: GO:0042377 name: vitamin K catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "naphthoquinone catabolic process" EXACT [] synonym: "naphthoquinone catabolism" EXACT [] synonym: "vitamin K breakdown" EXACT [] synonym: "vitamin K catabolism" EXACT [] synonym: "vitamin K degradation" EXACT [] is_a: GO:0042363 ! fat-soluble vitamin catabolic process is_a: GO:0042373 ! vitamin K metabolic process [Term] id: GO:0042379 name: chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any chemokine receptor." [GOC:ai] synonym: "chemokine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0042380 name: hydroxymethylbutenyl pyrophosphate reductase activity namespace: molecular_function def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js, PMID:11818558] synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0042381 name: hemolymph coagulation namespace: biological_process def: "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] synonym: "hemolymph clotting" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0007599 ! hemostasis is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0045087 ! innate immune response is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0042382 name: paraspeckles namespace: cellular_component def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] xref: Wikipedia:Paraspeckle is_a: GO:0016604 ! nuclear body [Term] id: GO:0042383 name: sarcolemma namespace: cellular_component def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732] xref: Wikipedia:Sarcolemma is_a: GO:0005886 ! plasma membrane [Term] id: GO:0042385 name: myosin III complex namespace: cellular_component def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0042386 name: hemocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] synonym: "arthropod blood cell differentiation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0030154 ! cell differentiation [Term] id: GO:0042387 name: plasmatocyte differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] is_a: GO:0042386 ! hemocyte differentiation [Term] id: GO:0042388 name: gibberellic acid mediated signaling pathway, G-alpha-dependent namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT [] is_a: GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0042389 name: omega-3 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020] xref: EC:1.14.99 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0042390 name: gibberellic acid mediated signaling pathway, G-alpha-independent namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT [] is_a: GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0042391 name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042392 name: sphingosine-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102] synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] synonym: "SPP phosphatase activity" EXACT [] synonym: "SPPase activity" EXACT [] xref: MetaCyc:RXN3DJ-25 xref: Reactome:R-HSA-428690 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]" xref: Reactome:R-HSA-428696 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]" xref: Reactome:R-HSA-428701 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]" is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0042393 name: histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "histone-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042394 name: obsolete ecdysis, protein-based cuticle namespace: biological_process def: "OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "ecdysis, protein-based cuticle" EXACT [] is_obsolete: true consider: GO:0018990 consider: GO:0042395 [Term] id: GO:0042395 name: ecdysis, collagen and cuticulin-based cuticle namespace: biological_process def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle [Term] id: GO:0042396 name: phosphagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] synonym: "phosphagen anabolism" EXACT [] synonym: "phosphagen biosynthesis" EXACT [] synonym: "phosphagen formation" EXACT [] synonym: "phosphagen synthesis" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0042397 name: phosphagen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] synonym: "phosphagen breakdown" EXACT [] synonym: "phosphagen catabolism" EXACT [] synonym: "phosphagen degradation" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0042398 name: cellular modified amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid derivative biosynthetic process" EXACT [] synonym: "cellular amino acid derivative anabolism" EXACT [] synonym: "cellular amino acid derivative biosynthesis" EXACT [] synonym: "cellular amino acid derivative biosynthetic process" EXACT [] synonym: "cellular amino acid derivative formation" EXACT [] synonym: "cellular amino acid derivative synthesis" EXACT [] synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah] synonym: "cellular modified amino acid formation" EXACT [GOC:mah] synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah] is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042399 name: ectoine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] synonym: "ectoine metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042400 name: ectoine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] synonym: "ectoine breakdown" EXACT [] synonym: "ectoine catabolism" EXACT [] synonym: "ectoine degradation" EXACT [] is_a: GO:0042399 ! ectoine metabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042401 name: cellular biogenic amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine anabolism" EXACT [] synonym: "biogenic amine biosynthesis" EXACT [] synonym: "biogenic amine formation" EXACT [] synonym: "biogenic amine synthesis" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0042402 name: cellular biogenic amine catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] synonym: "biogenic amine breakdown" EXACT [] synonym: "biogenic amine catabolism" EXACT [] synonym: "biogenic amine degradation" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009310 ! amine catabolic process [Term] id: GO:0042403 name: thyroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] synonym: "thyroid hormone metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042404 name: thyroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] synonym: "thyroid hormone breakdown" EXACT [] synonym: "thyroid hormone catabolism" EXACT [] synonym: "thyroid hormone degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042403 ! thyroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0042405 name: nuclear inclusion body namespace: cellular_component def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl] is_a: GO:0016234 ! inclusion body intersection_of: GO:0016234 ! inclusion body intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0042406 name: extrinsic component of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] synonym: "extrinsic to endoplasmic reticulum membrane" NARROW [] synonym: "extrinsic to ER membrane" EXACT [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0042407 name: cristae formation namespace: biological_process def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] is_a: GO:0007007 ! inner mitochondrial membrane organization [Term] id: GO:0042408 name: obsolete myrcene/(E)-beta-ocimene synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382] comment: This term was made obsolete because it represents two activities. synonym: "myrcene/(E)-beta-ocimene synthase activity" EXACT [] synonym: "myrcene/ocimene synthase activity" EXACT [] xref: EC:4.6 is_obsolete: true [Term] id: GO:0042409 name: caffeoyl-CoA O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT [] synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] xref: EC:2.1.1.104 xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN xref: RHEA:16925 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0042410 name: 6-carboxyhexanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA." [EC:6.2.1.14, RHEA:14781] synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14] synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14] synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14] xref: EC:6.2.1.14 xref: KEGG_REACTION:R03209 xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN xref: RHEA:14781 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0042412 name: taurine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine anabolism" EXACT [] synonym: "taurine biosynthesis" EXACT [] synonym: "taurine formation" EXACT [] synonym: "taurine synthesis" EXACT [] is_a: GO:0019530 ! taurine metabolic process is_a: GO:0046305 ! alkanesulfonate biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042413 name: carnitine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] synonym: "carnitine breakdown" EXACT [] synonym: "carnitine catabolism" EXACT [] synonym: "carnitine degradation" EXACT [] synonym: "vitamin Bt catabolic process" EXACT [] synonym: "vitamin Bt catabolism" EXACT [] is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0042414 name: epinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline metabolic process" EXACT [] synonym: "adrenaline metabolism" EXACT [] synonym: "epinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042415 name: norepinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol metabolic process" EXACT [] synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process [Term] id: GO:0042416 name: dopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine anabolism" EXACT [] synonym: "dopamine biosynthesis" EXACT [] synonym: "dopamine formation" EXACT [] synonym: "dopamine synthesis" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042417 name: dopamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0042418 name: epinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline biosynthesis" EXACT [] synonym: "adrenaline biosynthetic process" EXACT [] synonym: "epinephrine anabolism" EXACT [] synonym: "epinephrine biosynthesis" EXACT [] synonym: "epinephrine formation" EXACT [] synonym: "epinephrine synthesis" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042419 name: epinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] synonym: "adrenaline catabolic process" EXACT [] synonym: "adrenaline catabolism" EXACT [] synonym: "epinephrine breakdown" EXACT [] synonym: "epinephrine catabolism" EXACT [] synonym: "epinephrine degradation" EXACT [] is_a: GO:0042414 ! epinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process [Term] id: GO:0042420 name: dopamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine breakdown" EXACT [] synonym: "dopamine catabolism" EXACT [] synonym: "dopamine degradation" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042424 ! catecholamine catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042421 name: norepinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol biosynthesis" EXACT [] synonym: "levarterenol biosynthetic process" EXACT [] synonym: "noradrenaline biosynthesis" EXACT [] synonym: "noradrenaline biosynthetic process" EXACT [] synonym: "norepinephrine anabolism" EXACT [] synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process [Term] id: GO:0042422 name: norepinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol catabolic process" EXACT [] synonym: "levarterenol catabolism" EXACT [] synonym: "noradrenaline catabolic process" EXACT [] synonym: "noradrenaline catabolism" EXACT [] synonym: "norepinephrine breakdown" EXACT [] synonym: "norepinephrine catabolism" EXACT [] synonym: "norepinephrine degradation" EXACT [] xref: Wikipedia:Norepinephrine#Degradation is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process [Term] id: GO:0042423 name: catecholamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine anabolism" EXACT [] synonym: "catecholamine biosynthesis" EXACT [] synonym: "catecholamine formation" EXACT [] synonym: "catecholamine synthesis" EXACT [] xref: MIPS_funcat:01.20.35.03 xref: Wikipedia:Catecholamines is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042424 name: catecholamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine breakdown" EXACT [] synonym: "catecholamine catabolism" EXACT [] synonym: "catecholamine degradation" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042425 name: choline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] synonym: "choline anabolism" EXACT [] synonym: "choline biosynthesis" EXACT [] synonym: "choline formation" EXACT [] synonym: "choline synthesis" EXACT [] xref: MetaCyc:PWY-4762 is_a: GO:0019695 ! choline metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0042426 name: choline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] synonym: "choline breakdown" EXACT [] synonym: "choline catabolism" EXACT [] synonym: "choline degradation" EXACT [] is_a: GO:0019695 ! choline metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0042427 name: serotonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism" EXACT [] synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process [Term] id: GO:0042428 name: serotonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0042429 name: serotonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0042430 name: indole-containing compound metabolic process namespace: biological_process alt_id: GO:0042434 def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah] synonym: "indole and derivative metabolic process" EXACT [] synonym: "indole and derivative metabolism" EXACT [] synonym: "indole derivative metabolic process" NARROW [] synonym: "indole derivative metabolism" NARROW [] synonym: "indole-containing compound metabolism" EXACT [] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042431 name: indole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] synonym: "indole metabolism" EXACT [] is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0042432 name: indole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] synonym: "indole anabolism" EXACT [] synonym: "indole biosynthesis" EXACT [] synonym: "indole formation" EXACT [] synonym: "indole synthesis" EXACT [] is_a: GO:0042431 ! indole metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0042433 name: indole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] synonym: "indole breakdown" EXACT [] synonym: "indole catabolism" EXACT [] synonym: "indole degradation" EXACT [] is_a: GO:0042431 ! indole metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0042435 name: indole-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative biosynthesis" EXACT [] synonym: "indole derivative biosynthetic process" EXACT [] synonym: "indole-containing compound anabolism" EXACT [] synonym: "indole-containing compound biosynthesis" EXACT [] synonym: "indole-containing compound formation" EXACT [] synonym: "indole-containing compound synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042436 name: indole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative catabolic process" EXACT [] synonym: "indole derivative catabolism" EXACT [] synonym: "indole-containing compound breakdown" EXACT [] synonym: "indole-containing compound catabolism" EXACT [] synonym: "indole-containing compound degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042437 name: indoleacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl] synonym: "IAA catabolic process" EXACT [] synonym: "indole acetic acid catabolic process" EXACT [] synonym: "indole acetic acid catabolism" EXACT [] synonym: "indoleacetic acid breakdown" EXACT [] synonym: "indoleacetic acid catabolism" EXACT [] synonym: "indoleacetic acid degradation" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009852 ! auxin catabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042438 name: melanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:curators] synonym: "melanin anabolism" EXACT [] synonym: "melanin biosynthesis" EXACT [] synonym: "melanin formation" EXACT [] synonym: "melanin synthesis" EXACT [] xref: MIPS_funcat:01.20.35.01.01 is_a: GO:0006582 ! melanin metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0042439 name: ethanolamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [GOC:mah] synonym: "ethanolamine and derivative metabolic process" EXACT [] synonym: "ethanolamine and derivative metabolism" EXACT [] synonym: "ethanolamine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0042440 name: pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] subset: goslim_pir synonym: "pigment metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0042441 name: eye pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment metabolism" EXACT [] is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation relationship: part_of GO:0048069 ! eye pigmentation [Term] id: GO:0042442 name: melatonin catabolic process namespace: biological_process alt_id: GO:0042449 def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] synonym: "melatonin breakdown" EXACT [] synonym: "melatonin catabolism" EXACT [] synonym: "melatonin degradation" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042443 name: phenylethylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0042444 name: phenylethylamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine anabolism" EXACT [] synonym: "phenylethylamine biosynthesis" EXACT [] synonym: "phenylethylamine formation" EXACT [] synonym: "phenylethylamine synthesis" EXACT [] is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0042443 ! phenylethylamine metabolic process is_a: GO:1901162 ! primary amino compound biosynthetic process [Term] id: GO:0042445 name: hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] subset: goslim_pir synonym: "hormone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0042446 name: hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone anabolism" EXACT [] synonym: "hormone biosynthesis" EXACT [] synonym: "hormone formation" EXACT [] synonym: "hormone synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042447 name: hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone breakdown" EXACT [] synonym: "hormone catabolism" EXACT [] synonym: "hormone degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042448 name: progesterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0042450 name: arginine biosynthetic process via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl] synonym: "arginine anabolism via ornithine" EXACT [] synonym: "arginine formation via ornithine" EXACT [] synonym: "arginine synthesis via ornithine" EXACT [] is_a: GO:0006526 ! arginine biosynthetic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0042451 name: purine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] synonym: "purine nucleoside anabolism" EXACT [] synonym: "purine nucleoside biosynthesis" EXACT [] synonym: "purine nucleoside formation" EXACT [] synonym: "purine nucleoside synthesis" EXACT [] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0042452 name: deoxyguanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] synonym: "deoxyguanosine anabolism" EXACT [] synonym: "deoxyguanosine biosynthesis" EXACT [] synonym: "deoxyguanosine formation" EXACT [] synonym: "deoxyguanosine synthesis" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0042453 name: deoxyguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] synonym: "deoxyguanosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0042454 name: ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] synonym: "ribonucleoside breakdown" EXACT [] synonym: "ribonucleoside catabolism" EXACT [] synonym: "ribonucleoside degradation" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process [Term] id: GO:0042455 name: ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] synonym: "ribonucleoside anabolism" EXACT [] synonym: "ribonucleoside biosynthesis" EXACT [] synonym: "ribonucleoside formation" EXACT [] synonym: "ribonucleoside synthesis" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process [Term] id: GO:0042457 name: ethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845] synonym: "ethene catabolic process" EXACT [] synonym: "ethene catabolism" EXACT [] synonym: "ethylene breakdown" EXACT [] synonym: "ethylene catabolism" EXACT [] synonym: "ethylene degradation" EXACT [] is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0042458 name: nopaline catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators] synonym: "nopaline breakdown to proline" EXACT [] synonym: "nopaline degradation to proline" EXACT [] xref: MetaCyc:NOPALINEDEG-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0019468 ! nopaline catabolic process [Term] id: GO:0042459 name: octopine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators] synonym: "octopine breakdown to proline" EXACT [] synonym: "octopine degradation to proline" EXACT [] xref: MetaCyc:OCTOPINEDEG-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0019469 ! octopine catabolic process [Term] id: GO:0042461 name: photoreceptor cell development namespace: biological_process alt_id: GO:0046531 def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] synonym: "photoreceptor morphogenesis" EXACT [] is_a: GO:0048666 ! neuron development relationship: part_of GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0042462 name: eye photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] is_a: GO:0042461 ! photoreceptor cell development relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation [Term] id: GO:0042463 name: ocellus photoreceptor cell development namespace: biological_process alt_id: GO:0001749 def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766] synonym: "non-eye photoreceptor development" BROAD [] is_a: GO:0042461 ! photoreceptor cell development relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation [Term] id: GO:0042464 name: dosage compensation by hypoactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:11102361, PMID:20622855] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0042465 name: kinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023] xref: Wikipedia:Kinesis is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0042466 name: chemokinesis namespace: biological_process def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411] xref: Wikipedia:Chemokinesis is_a: GO:0042465 ! kinesis [Term] id: GO:0042467 name: orthokinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088] is_a: GO:0042465 ! kinesis [Term] id: GO:0042468 name: klinokinesis namespace: biological_process def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068] is_a: GO:0042465 ! kinesis [Term] id: GO:0042469 name: versicolorin reductase activity namespace: molecular_function def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0042470 name: melanosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] xref: Wikipedia:Melanosome is_a: GO:0048770 ! pigment granule [Term] id: GO:0042471 name: ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ morphogenesis" EXACT [] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0043583 ! ear development [Term] id: GO:0042472 name: inner ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0042473 name: outer ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis [Term] id: GO:0042474 name: middle ear morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042471 ! ear morphogenesis [Term] id: GO:0042475 name: odontogenesis of dentin-containing tooth namespace: biological_process def: "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794] comment: Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See http://en.wikipedia.org/wiki/Placoid_scale#Placoid_scales. synonym: "odontogenesis of dentine-containing teeth" EXACT [] synonym: "odontogenesis of dentine-containing tooth" EXACT [GOC:mah] synonym: "odontogeny" BROAD [] synonym: "odontosis" BROAD [] synonym: "tooth development" BROAD [] is_a: GO:0042476 ! odontogenesis [Term] id: GO:0042476 name: odontogenesis namespace: biological_process alt_id: GO:0042477 def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah] synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "odontogeny" EXACT [] synonym: "odontosis" EXACT [] synonym: "tooth development" RELATED [] synonym: "tooth morphogenesis" EXACT [] xref: MIPS_funcat:47.03.11.01 xref: Wikipedia:Odontogenesis is_a: GO:0009887 ! animal organ morphogenesis [Term] id: GO:0042478 name: regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "regulation of eye photoreceptor development" EXACT [] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042462 ! eye photoreceptor cell development relationship: regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042479 name: positive regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "activation of eye photoreceptor cell development" NARROW [] synonym: "positive regulation of eye photoreceptor development" EXACT [] synonym: "stimulation of eye photoreceptor cell development" NARROW [] synonym: "up regulation of eye photoreceptor cell development" EXACT [] synonym: "up-regulation of eye photoreceptor cell development" EXACT [] synonym: "upregulation of eye photoreceptor cell development" EXACT [] is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042462 ! eye photoreceptor cell development relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042480 name: negative regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "down regulation of eye photoreceptor cell development" EXACT [] synonym: "down-regulation of eye photoreceptor cell development" EXACT [] synonym: "downregulation of eye photoreceptor cell development" EXACT [] synonym: "inhibition of eye photoreceptor cell development" NARROW [] synonym: "negative regulation of eye photoreceptor development" EXACT [] is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042462 ! eye photoreceptor cell development relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development [Term] id: GO:0042481 name: regulation of odontogenesis namespace: biological_process alt_id: GO:0042484 def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "regulation of tooth development" EXACT [] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042476 ! odontogenesis relationship: regulates GO:0042476 ! odontogenesis [Term] id: GO:0042482 name: positive regulation of odontogenesis namespace: biological_process alt_id: GO:0042485 def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "activation of odontogenesis" NARROW [] synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "positive regulation of tooth development" EXACT [] synonym: "stimulation of odontogenesis" NARROW [] synonym: "up regulation of odontogenesis" EXACT [] synonym: "up-regulation of odontogenesis" EXACT [] synonym: "upregulation of odontogenesis" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042476 ! odontogenesis relationship: positively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042483 name: negative regulation of odontogenesis namespace: biological_process alt_id: GO:0042486 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] synonym: "down regulation of odontogenesis" EXACT [] synonym: "down-regulation of odontogenesis" EXACT [] synonym: "downregulation of odontogenesis" EXACT [] synonym: "inhibition of odontogenesis" NARROW [] synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] synonym: "negative regulation of tooth development" EXACT [] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042476 ! odontogenesis relationship: negatively_regulates GO:0042476 ! odontogenesis [Term] id: GO:0042487 name: regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "regulation of odontogenesis of dentine-containing tooth" EXACT [GOC:mah] is_a: GO:0042481 ! regulation of odontogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042475 ! odontogenesis of dentin-containing tooth relationship: regulates GO:0042475 ! odontogenesis of dentin-containing tooth [Term] id: GO:0042488 name: positive regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [dictyBase_REF:2530, GOC:jl, PMID:15355794] synonym: "activation of odontogenesis" BROAD [] synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "positive regulation of odontogenesis of dentine-containing tooth" RELATED [] synonym: "stimulation of odontogenesis" BROAD [] synonym: "up regulation of odontogenesis" BROAD [] synonym: "up-regulation of odontogenesis" BROAD [] synonym: "upregulation of odontogenesis" BROAD [] is_a: GO:0042482 ! positive regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth relationship: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth [Term] id: GO:0042489 name: negative regulation of odontogenesis of dentin-containing tooth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794] synonym: "down regulation of odontogenesis" BROAD [] synonym: "down-regulation of odontogenesis" BROAD [] synonym: "downregulation of odontogenesis" BROAD [] synonym: "inhibition of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis" BROAD [] synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT [] synonym: "negative regulation of odontogenesis of dentine-containing tooth" RELATED [] is_a: GO:0042483 ! negative regulation of odontogenesis is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth relationship: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth [Term] id: GO:0042490 name: mechanoreceptor differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0042491 name: inner ear auditory receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl] comment: Note that this term refers to the mechanosensory hair cells of the inner ear. synonym: "auditory hair cell differentiation" EXACT [] synonym: "auditory receptor cell differentiation" RELATED [] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0060113 ! inner ear receptor cell differentiation is_a: GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0042492 name: gamma-delta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development" RELATED [GOC:add] synonym: "gamma-delta T lymphocyte differentiation" EXACT [] synonym: "gamma-delta T-cell differentiation" EXACT [] synonym: "gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0042493 name: response to drug namespace: biological_process alt_id: GO:0017035 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] subset: goslim_candida synonym: "drug resistance" RELATED [] synonym: "drug susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0042494 name: detection of bacterial lipoprotein namespace: biological_process def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] synonym: "detection of BLP" RELATED [] synonym: "detection of Lpp" RELATED [] synonym: "perception of bacterial lipoprotein" RELATED [] synonym: "perception of BLP" RELATED [] synonym: "perception of Lpp" RELATED [] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032493 ! response to bacterial lipoprotein relationship: part_of GO:0016045 ! detection of bacterium [Term] id: GO:0042495 name: detection of triacyl bacterial lipopeptide namespace: biological_process def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "detection of triacylated bacterial lipoprotein" EXACT [GOC:add] synonym: "perception of triacylated bacterial lipopeptide" RELATED [GOC:add] synonym: "perception of triacylated bacterial lipoprotein" RELATED [] is_a: GO:0070340 ! detection of bacterial lipopeptide is_a: GO:0071725 ! response to triacyl bacterial lipopeptide [Term] id: GO:0042496 name: detection of diacyl bacterial lipopeptide namespace: biological_process def: "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "detection of diacylated bacterial lipoprotein" EXACT [GOC:add] synonym: "perception of diacylated bacterial lipopeptide" RELATED [GOC:add] synonym: "perception of diacylated bacterial lipoprotein" RELATED [] is_a: GO:0070340 ! detection of bacterial lipopeptide is_a: GO:0071724 ! response to diacyl bacterial lipopeptide [Term] id: GO:0042497 name: triacyl lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial triacyl lipopeptide binding" NARROW [GOC:add] synonym: "bacterial triacyl lipoprotein binding" RELATED [GOC:add] synonym: "triacylated lipopeptide binding" EXACT [] is_a: GO:0071723 ! lipopeptide binding [Term] id: GO:0042498 name: diacyl lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial diacyl lipopeptide binding" NARROW [GOC:add] synonym: "bacterial diacyl lipoprotein binding" RELATED [GOC:add] synonym: "diacylated lipopeptide binding" EXACT [] is_a: GO:0071723 ! lipopeptide binding [Term] id: GO:0042499 name: obsolete signal peptide peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416] comment: This term was made obsolete because it represents a gene product. synonym: "signal peptide peptidase activity" EXACT [] synonym: "SPP" EXACT [] xref: EC:3.4.23 is_obsolete: true replaced_by: GO:0042500 [Term] id: GO:0042500 name: aspartic endopeptidase activity, intramembrane cleaving namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732] comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. xref: EC:3.4.23 xref: Reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)" is_a: GO:0004190 ! aspartic-type endopeptidase activity [Term] id: GO:0042501 name: serine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0033136 def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] synonym: "serine phosphorylation of STAT3 protein" NARROW [] is_a: GO:0018105 ! peptidyl-serine phosphorylation relationship: part_of GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT [Term] id: GO:0042509 name: regulation of tyrosine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0042510 alt_id: GO:0042513 alt_id: GO:0042516 alt_id: GO:0042519 alt_id: GO:0042522 alt_id: GO:0042525 alt_id: GO:0042528 def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] synonym: "regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042531 name: positive regulation of tyrosine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0042511 alt_id: GO:0042515 alt_id: GO:0042517 alt_id: GO:0042520 alt_id: GO:0042523 alt_id: GO:0042526 alt_id: GO:0042529 def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "positive regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein is_a: GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042532 name: negative regulation of tyrosine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0042512 alt_id: GO:0042514 alt_id: GO:0042518 alt_id: GO:0042521 alt_id: GO:0042524 alt_id: GO:0042527 alt_id: GO:0042530 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT [] synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein is_a: GO:0046426 ! negative regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein [Term] id: GO:0042533 name: tumor necrosis factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "TNF alpha biosynthesis" EXACT [] synonym: "TNF alpha biosynthetic process" EXACT [] synonym: "TNF biosynthesis" EXACT [] synonym: "TNF biosynthetic process" EXACT [] synonym: "TNF-alpha biosynthesis" EXACT [] synonym: "TNF-alpha biosynthetic process" EXACT [] synonym: "Tumor Necrosis Factor alpha biosynthesis" EXACT [] synonym: "Tumor Necrosis Factor alpha biosynthetic process" EXACT [] synonym: "tumor necrosis factor anabolism" EXACT [] synonym: "tumor necrosis factor biosynthesis" EXACT [] synonym: "tumor necrosis factor formation" EXACT [] synonym: "tumor necrosis factor synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032640 ! tumor necrosis factor production [Term] id: GO:0042534 name: regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of TNF alpha biosynthesis" EXACT [] synonym: "regulation of TNF alpha biosynthetic process" EXACT [] synonym: "regulation of TNF biosynthesis" EXACT [] synonym: "regulation of TNF biosynthetic process" EXACT [] synonym: "regulation of TNF-alpha biosynthesis" EXACT [] synonym: "regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "regulation of tumor necrosis factor anabolism" EXACT [] synonym: "regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor formation" EXACT [] synonym: "regulation of tumor necrosis factor synthesis" EXACT [] synonym: "regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042533 ! tumor necrosis factor biosynthetic process relationship: regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042535 name: positive regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "positive regulation of TNF alpha biosynthesis" EXACT [] synonym: "positive regulation of TNF alpha biosynthetic process" EXACT [] synonym: "positive regulation of TNF biosynthesis" EXACT [] synonym: "positive regulation of TNF biosynthetic process" EXACT [] synonym: "positive regulation of TNF-alpha biosynthesis" EXACT [] synonym: "positive regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "positive regulation of tumor necrosis factor anabolism" EXACT [] synonym: "positive regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor formation" EXACT [] synonym: "positive regulation of tumor necrosis factor synthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] synonym: "stimulation of tumor necrosis factor biosynthetic process" NARROW [] synonym: "up regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "up-regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "upregulation of tumor necrosis factor biosynthetic process" EXACT [] is_a: GO:0032760 ! positive regulation of tumor necrosis factor production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process relationship: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042536 name: negative regulation of tumor necrosis factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "down-regulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "downregulation of tumor necrosis factor biosynthetic process" EXACT [] synonym: "inhibition of tumor necrosis factor biosynthetic process" NARROW [] synonym: "negative regulation of TNF alpha biosynthesis" EXACT [] synonym: "negative regulation of TNF alpha biosynthetic process" EXACT [] synonym: "negative regulation of TNF biosynthesis" EXACT [] synonym: "negative regulation of TNF biosynthetic process" EXACT [] synonym: "negative regulation of TNF-alpha biosynthesis" EXACT [] synonym: "negative regulation of TNF-alpha biosynthetic process" EXACT [] synonym: "negative regulation of tumor necrosis factor anabolism" EXACT [] synonym: "negative regulation of tumor necrosis factor biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor formation" EXACT [] synonym: "negative regulation of tumor necrosis factor synthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] is_a: GO:0032720 ! negative regulation of tumor necrosis factor production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process relationship: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process [Term] id: GO:0042537 name: benzene-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [GOC:jl] synonym: "benzene and derivative metabolic process" EXACT [] synonym: "benzene and derivative metabolism" EXACT [] synonym: "benzene-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0042538 name: hyperosmotic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hyperosmotic salt stress" EXACT [] synonym: "salt tolerance" RELATED [] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0009651 ! response to salt stress [Term] id: GO:0042539 name: hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hypotonic salt stress" EXACT [] is_a: GO:0006971 ! hypotonic response is_a: GO:0009651 ! response to salt stress [Term] id: GO:0042540 name: hemoglobin catabolic process namespace: biological_process alt_id: GO:0020029 def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [GOC:jl, GOC:mb] comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process. synonym: "haemoglobin catabolic process" EXACT [] synonym: "haemoglobin catabolism" EXACT [] synonym: "haemoglobin hydrolysis" NARROW [] synonym: "hemoglobin breakdown" EXACT [] synonym: "hemoglobin catabolism" EXACT [] synonym: "hemoglobin degradation" EXACT [] synonym: "hemoglobin hydrolysis" NARROW [] is_a: GO:0020027 ! hemoglobin metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0042541 name: hemoglobin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl] synonym: "haemoglobin biosynthesis" EXACT [] synonym: "haemoglobin biosynthetic process" EXACT [] synonym: "hemoglobin anabolism" EXACT [] synonym: "hemoglobin biosynthesis" EXACT [] synonym: "hemoglobin formation" EXACT [] synonym: "hemoglobin synthesis" EXACT [] is_a: GO:0020027 ! hemoglobin metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042542 name: response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0009636 ! response to toxic substance is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0042543 name: protein N-linked glycosylation via arginine namespace: biological_process def: "The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327] synonym: "protein amino acid N-linked glycosylation via arginine" EXACT [GOC:bf] xref: RESID:AA0327 is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0042544 name: melibiose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732] synonym: "melibiose anabolism" EXACT [] synonym: "melibiose biosynthesis" EXACT [] synonym: "melibiose formation" EXACT [] synonym: "melibiose synthesis" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0042545 name: cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl] is_a: GO:0071555 ! cell wall organization [Term] id: GO:0042546 name: cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732] synonym: "cell wall assembly" NARROW [] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0042547 name: cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell wall modification during cell expansion" EXACT [] synonym: "cell wall modification during multidimensional cell growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0042545 ! cell wall modification intersection_of: GO:0042545 ! cell wall modification intersection_of: part_of GO:0009825 ! multidimensional cell growth relationship: part_of GO:0009825 ! multidimensional cell growth [Term] id: GO:0042548 name: regulation of photosynthesis, light reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019684 ! photosynthesis, light reaction relationship: regulates GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0042549 name: photosystem II stabilization namespace: biological_process def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] is_a: GO:0042548 ! regulation of photosynthesis, light reaction [Term] id: GO:0042550 name: photosystem I stabilization namespace: biological_process def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] is_a: GO:0042548 ! regulation of photosynthesis, light reaction [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0042552 name: myelination namespace: biological_process def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429] xref: Wikipedia:Myelin is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0042554 name: superoxide anion generation namespace: biological_process def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750] synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah] is_a: GO:0006801 ! superoxide metabolic process [Term] id: GO:0042555 name: MCM complex namespace: cellular_component def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] synonym: "mini-chromosome maintenance complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0097373 ! MCM core complex [Term] id: GO:0042556 name: eukaryotic elongation factor-2 kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase regulator" EXACT [] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0042557 name: eukaryotic elongation factor-2 kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] synonym: "eEF-2 kinase activator" EXACT [] is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity is_a: GO:0043539 ! protein serine/threonine kinase activator activity [Term] id: GO:0042558 name: pteridine-containing compound metabolic process namespace: biological_process alt_id: GO:0019721 def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] synonym: "pteridine and derivative metabolic process" EXACT [] synonym: "pteridine and derivative metabolism" EXACT [] synonym: "pteridine-containing compound metabolism" EXACT [] synonym: "pterin metabolic process" NARROW [] synonym: "pterin metabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042559 name: pteridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] synonym: "pteridine and derivative biosynthesis" EXACT [] synonym: "pteridine and derivative biosynthetic process" EXACT [] synonym: "pteridine-containing compound anabolism" EXACT [] synonym: "pteridine-containing compound biosynthesis" EXACT [] synonym: "pteridine-containing compound formation" EXACT [] synonym: "pteridine-containing compound synthesis" EXACT [] synonym: "pterin biosynthesis" NARROW [] synonym: "pterin biosynthetic process" NARROW [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042560 name: pteridine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] synonym: "pteridine and derivative catabolic process" EXACT [] synonym: "pteridine and derivative catabolism" EXACT [] synonym: "pteridine-containing compound breakdown" EXACT [] synonym: "pteridine-containing compound catabolism" EXACT [] synonym: "pteridine-containing compound degradation" EXACT [] synonym: "pterin catabolic process" NARROW [] synonym: "pterin catabolism" NARROW [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042561 name: alpha-amyrin synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960] xref: MetaCyc:RXN-8434 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042563 name: obsolete importin alpha-subunit nuclear export complex namespace: cellular_component def: "OBSOLETE. A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to transport the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] comment: The reason for obsoletion is that these terms include the substrate of the reaction. is_obsolete: true [Term] id: GO:0042564 name: NLS-dependent protein nuclear import complex namespace: cellular_component def: "A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134, Wikipedia:Importin] is_a: GO:0031074 ! nucleocytoplasmic transport complex [Term] id: GO:0042565 name: RNA nuclear export complex namespace: cellular_component def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123] is_a: GO:0031074 ! nucleocytoplasmic transport complex [Term] id: GO:0042566 name: hydrogenosome namespace: cellular_component def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569] subset: goslim_pir xref: Wikipedia:Hydrogenosome is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0042567 name: insulin-like growth factor ternary complex namespace: cellular_component def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF ternary complex" EXACT [] is_a: GO:0016942 ! insulin-like growth factor binding protein complex [Term] id: GO:0042568 name: insulin-like growth factor binary complex namespace: cellular_component def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] synonym: "IGF binary complex" EXACT [] is_a: GO:0016942 ! insulin-like growth factor binding protein complex [Term] id: GO:0042571 name: immunoglobulin complex, circulating namespace: cellular_component def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" EXACT [GOC:add] xref: Wikipedia:Antibody is_a: GO:0019814 ! immunoglobulin complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0042572 name: retinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] synonym: "retinol metabolism" EXACT [] synonym: "vitamin A1 alcohol metabolic process" EXACT [] synonym: "vitamin A1 alcohol metabolism" EXACT [] synonym: "vitamin A1 metabolic process" EXACT [] synonym: "vitamin A1 metabolism" EXACT [] xref: Wikipedia:Retinol is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0042573 name: retinoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "retinoic acid metabolism" EXACT [] synonym: "vitamin A1 acid metabolic process" EXACT [] synonym: "vitamin A1 acid metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0042574 name: retinal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [ISBN:0198506732] synonym: "retinal metabolism" EXACT [] synonym: "retinaldehyde metabolic process" EXACT [] synonym: "retinaldehyde metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0042575 name: DNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0042576 name: obsolete aspartyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] comment: This term was made obsolete because it represents a gene product. synonym: "aspartyl aminopeptidase activity" EXACT [] xref: EC:3.4.11.21 xref: MetaCyc:3.4.11.21-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0042577 name: lipid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0042578 name: phosphoric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0042579 name: microbody namespace: cellular_component def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] subset: goslim_pir xref: Wikipedia:Microbody is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0042580 name: mannosome namespace: cellular_component def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531] is_a: GO:0005777 ! peroxisome [Term] id: GO:0042581 name: specific granule namespace: cellular_component def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544, PMID:7334549] synonym: "secondary granule" EXACT [] xref: Wikipedia:Specific_granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0042582 name: azurophil granule namespace: cellular_component def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, PMID:17152095] synonym: "primary granule" EXACT [] is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0042583 name: chromaffin granule namespace: cellular_component def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743] is_a: GO:0030141 ! secretory granule [Term] id: GO:0042584 name: chromaffin granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042583 ! chromaffin granule [Term] id: GO:0042585 name: germinal vesicle namespace: cellular_component def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837] synonym: "primary oocyte nucleus" EXACT [] is_a: GO:0001674 ! female germ cell nucleus [Term] id: GO:0042586 name: peptide deformylase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl] synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88] synonym: "PDF activity" EXACT [EC:3.5.1.88] synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88] xref: EC:3.5.1.88 xref: MetaCyc:3.5.1.88-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0042587 name: glycogen granule namespace: cellular_component def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957] synonym: "glycogen particle" EXACT [] xref: NIF_Subcellular:sao1081228141 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0042588 name: zymogen granule namespace: cellular_component def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732] is_a: GO:0030141 ! secretory granule [Term] id: GO:0042589 name: zymogen granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042588 ! zymogen granule [Term] id: GO:0042590 name: antigen processing and presentation of exogenous peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT [] synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT [] synonym: "cross presentation" BROAD [] synonym: "cross priming" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "cross-priming" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0042592 name: homeostatic process namespace: biological_process alt_id: GO:0032844 alt_id: GO:0032845 alt_id: GO:0032846 def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] is_a: GO:0033500 ! carbohydrate homeostasis [Term] id: GO:0042594 name: response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] subset: goslim_yeast xref: MIPS_funcat:32.01.11 is_a: GO:0006950 ! response to stress is_a: GO:0031667 ! response to nutrient levels [Term] id: GO:0042595 name: behavioral response to starvation namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] synonym: "behavioural response to starvation" EXACT [] is_a: GO:0042594 ! response to starvation [Term] id: GO:0042596 name: fear response namespace: biological_process alt_id: GO:0001663 def: "The response of an organism to a perceived external threat." [GOC:go_curators] synonym: "physiological fear response" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0042597 name: periplasmic space namespace: cellular_component alt_id: GO:0005620 def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] subset: goslim_metagenomics subset: goslim_pir synonym: "periplasm" EXACT [] xref: MIPS_funcat:70.28 is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0042598 name: obsolete vesicular fraction namespace: cellular_component def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "vesicular fraction" EXACT [] is_obsolete: true consider: GO:0031982 [Term] id: GO:0042599 name: lamellar body namespace: cellular_component def: "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, http://en.wikipedia.org/wiki/Lamellar_granule, PMID:12243725] synonym: "keratinosome" NARROW [] synonym: "lamellar granule" EXACT [] synonym: "membrane-coating granule" EXACT [] synonym: "Odland body" NARROW [] xref: NIF_Subcellular:sao1379604862 is_a: GO:0030141 ! secretory granule [Term] id: GO:0042600 name: chorion namespace: cellular_component def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. subset: goslim_pir is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0042601 name: endospore-forming forespore namespace: cellular_component def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029] is_a: GO:0042763 ! intracellular immature spore [Term] id: GO:0042602 name: riboflavin reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [EC:1.5.1.30] synonym: "flavin reductase activity" RELATED [EC:1.5.1.30] synonym: "FMN reductase (NADPH) activity" RELATED [EC:1.5.1.30] synonym: "NADPH dehydrogenase (riboflavin) activity" EXACT [EC:1.5.1.30] synonym: "NADPH-dependent FMN reductase activity" RELATED [EC:1.5.1.30] synonym: "NADPH-FMN reductase activity" RELATED [EC:1.5.1.30] synonym: "NADPH-riboflavin oxidoreductase activity" EXACT [] synonym: "NADPH-riboflavin reductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH-specific FMN reductase activity" RELATED [EC:1.5.1.30] synonym: "NADPH2 dehydrogenase (riboflavin)" EXACT [EC:1.5.1.30] synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30] xref: EC:1.5.1.30 xref: EC:1.5.1.41 xref: KEGG_REACTION:R05707 xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN xref: RHEA:19377 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0042603 name: capsule namespace: cellular_component alt_id: GO:0030113 alt_id: GO:0042604 def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg] xref: Wikipedia:Capsule_(microbiology) is_a: GO:0030112 ! glycocalyx [Term] id: GO:0042605 name: peptide antigen binding namespace: molecular_function alt_id: GO:0042606 alt_id: GO:0042607 def: "Interacting selectively and non-covalently with an antigen peptide." [GOC:add, GOC:jl, GOC:rv] comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule. subset: goslim_chembl synonym: "endogenous peptide antigen binding" NARROW [] synonym: "exogenous peptide antigen binding" NARROW [] is_a: GO:0003823 ! antigen binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0042608 name: T cell receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl] synonym: "T lymphocyte receptor binding" EXACT [] synonym: "T-cell receptor binding" EXACT [] synonym: "T-lymphocyte receptor binding" EXACT [] synonym: "TCR binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0042609 name: CD4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MSH:D015704] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042610 name: CD8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MSH:D016827] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042611 name: MHC protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240] subset: goslim_pir is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0042612 name: MHC class I protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149] comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042613 name: MHC class II protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042614 name: CD70 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859] synonym: "CD27 receptor activity" RELATED [] synonym: "CD27L binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042615 name: CD154 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859] synonym: "CD40 receptor activity" RELATED [] synonym: "CD40L binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042616 name: paclitaxel metabolic process namespace: biological_process def: "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl] synonym: "paclitaxel metabolism" EXACT [] synonym: "taxol metabolic process" NARROW [] synonym: "taxol metabolism" NARROW [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0042617 name: paclitaxel biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl] synonym: "paclitaxel anabolism" EXACT [] synonym: "paclitaxel biosynthesis" EXACT [] synonym: "paclitaxel formation" EXACT [] synonym: "paclitaxel synthesis" EXACT [] synonym: "taxol biosynthesis" NARROW [] synonym: "taxol biosynthetic process" NARROW [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042616 ! paclitaxel metabolic process [Term] id: GO:0042618 name: poly-hydroxybutyrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] synonym: "PHB metabolic process" EXACT [] synonym: "PHB metabolism" EXACT [] synonym: "poly-hydroxybutyrate metabolism" EXACT [] is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process [Term] id: GO:0042619 name: poly-hydroxybutyrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] synonym: "PHB biosynthesis" EXACT [] synonym: "PHB biosynthetic process" EXACT [] synonym: "poly-hydroxybutyrate anabolism" EXACT [] synonym: "poly-hydroxybutyrate biosynthesis" EXACT [] synonym: "poly-hydroxybutyrate formation" EXACT [] synonym: "poly-hydroxybutyrate synthesis" EXACT [] is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process [Term] id: GO:0042620 name: poly(3-hydroxyalkanoate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] subset: goslim_pir synonym: "PHA metabolic process" BROAD [] synonym: "PHA metabolism" BROAD [] synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0042621 name: poly(3-hydroxyalkanoate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] synonym: "PHA biosynthesis" BROAD [] synonym: "PHA biosynthetic process" BROAD [] synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT [] synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT [] synonym: "poly(3-hydroxyalkanoate) formation" EXACT [] synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT [] is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0042622 name: photoreceptor outer segment membrane namespace: cellular_component def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl] is_a: GO:0060170 ! ciliary membrane relationship: part_of GO:0001750 ! photoreceptor outer segment [Term] id: GO:0042623 name: ATPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9] synonym: "chaperonin" RELATED [EC:3.6.4.9] synonym: "chaperonin ATPase activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "nucleoplasmin ATPase activity" RELATED [] synonym: "peroxisome-assembly ATPase activity" RELATED [] synonym: "vesicle-fusing ATPase activity" RELATED [EC:3.6.4.6] xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" is_a: GO:0016887 ! ATPase activity [Term] id: GO:0042624 name: obsolete ATPase activity, uncoupled namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [PMID:12912988] comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. is_obsolete: true [Term] id: GO:0042625 name: ATPase-coupled ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "ATP-dependent ion transmembrane transporter activity" EXACT [] synonym: "ATPase activity, coupled to transmembrane movement of ions" EXACT [] synonym: "ATPase coupled ion transmembrane transporter activity" EXACT [] is_a: GO:0022853 ! active ion transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0042626 name: ATPase-coupled transmembrane transporter activity namespace: molecular_function alt_id: GO:0015405 alt_id: GO:0016820 def: "Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729] comment: Merged with hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, see details in https://github.com/geneontology/go-ontology/issues/14642. Merged with GO:0015450, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, see https://github.com/geneontology/go-ontology/issues/1737. synonym: "ATP-coupled transmembrane transporter activity" EXACT [] synonym: "ATP-dependent transmembrane transporter activity" EXACT [] synonym: "ATPase activity, coupled to transmembrane movement of substances" EXACT [] synonym: "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" NARROW [] synonym: "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD [] synonym: "P-P-bond-hydrolysis-driven transporter" BROAD [] xref: EC:7.2.2 xref: MIPS_funcat:20.03.22 xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1" xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol" xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol" xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner" xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol" is_a: GO:0015399 ! primary active transmembrane transporter activity relationship: has_part GO:0016887 ! ATPase activity [Term] id: GO:0042627 name: chylomicron namespace: cellular_component def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, PMID:10580165] xref: Wikipedia:Chylomicron is_a: GO:0034358 ! plasma lipoprotein particle [Term] id: GO:0042628 name: mating plug formation namespace: biological_process def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893] synonym: "copulatory plug biosynthesis" EXACT [] synonym: "copulatory plug deposition" EXACT [] synonym: "copulatory plug formation" EXACT [] synonym: "mating plug deposition" EXACT [] is_a: GO:0007617 ! mating behavior is_a: GO:0045297 ! post-mating behavior relationship: part_of GO:0007320 ! insemination [Term] id: GO:0042629 name: mast cell granule namespace: cellular_component def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215] is_a: GO:0005764 ! lysosome [Term] id: GO:0042630 name: behavioral response to water deprivation namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl] synonym: "behavioral response to drought" EXACT [] synonym: "behavioral response to thirst" EXACT [] synonym: "behavioural response to water deprivation" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0009414 ! response to water deprivation [Term] id: GO:0042631 name: cellular response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators] synonym: "cellular response to drought" EXACT [] is_a: GO:0009414 ! response to water deprivation is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress is_a: GO:0071462 ! cellular response to water stimulus [Term] id: GO:0042632 name: cholesterol homeostasis namespace: biological_process alt_id: GO:2000188 alt_id: GO:2000189 def: "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] synonym: "positive regulation of cholesterol homeostasis" RELATED [] synonym: "regulation of cholesterol homeostasis" RELATED [] is_a: GO:0055092 ! sterol homeostasis [Term] id: GO:0042633 name: hair cycle namespace: biological_process def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] is_a: GO:0042303 ! molting cycle [Term] id: GO:0042634 name: regulation of hair cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042633 ! hair cycle relationship: regulates GO:0042633 ! hair cycle [Term] id: GO:0042635 name: positive regulation of hair cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "activation of hair cycle" NARROW [] synonym: "stimulation of hair cycle" NARROW [] synonym: "up regulation of hair cycle" EXACT [] synonym: "up-regulation of hair cycle" EXACT [] synonym: "upregulation of hair cycle" EXACT [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042633 ! hair cycle relationship: positively_regulates GO:0042633 ! hair cycle [Term] id: GO:0042636 name: negative regulation of hair cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] synonym: "down regulation of hair cycle" EXACT [] synonym: "down-regulation of hair cycle" EXACT [] synonym: "downregulation of hair cycle" EXACT [] synonym: "inhibition of hair cycle" NARROW [] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042633 ! hair cycle relationship: negatively_regulates GO:0042633 ! hair cycle [Term] id: GO:0042637 name: catagen namespace: biological_process def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193] subset: gocheck_do_not_annotate synonym: "hair regression" NARROW [] is_a: GO:0044851 ! hair cycle phase relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042638 name: exogen namespace: biological_process def: "The shedding phase of the hair cycle." [PMID:12230507] subset: gocheck_do_not_annotate synonym: "hair shedding" NARROW [] is_a: GO:0044851 ! hair cycle phase relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042639 name: telogen namespace: biological_process def: "The resting phase of hair cycle." [PMID:12230507] subset: gocheck_do_not_annotate synonym: "hair resting phase" NARROW [] is_a: GO:0044851 ! hair cycle phase [Term] id: GO:0042640 name: anagen namespace: biological_process def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507] subset: gocheck_do_not_annotate synonym: "hair growth" RELATED [] is_a: GO:0044851 ! hair cycle phase relationship: part_of GO:0048820 ! hair follicle maturation [Term] id: GO:0042641 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] synonym: "actomyosin complex" EXACT [] synonym: "actomyosin structure" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0042642 name: actomyosin, myosin complex part namespace: cellular_component def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] is_a: GO:0016459 ! myosin complex intersection_of: GO:0016459 ! myosin complex intersection_of: part_of GO:0042641 ! actomyosin relationship: part_of GO:0042641 ! actomyosin [Term] id: GO:0042643 name: actomyosin, actin portion namespace: cellular_component def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] is_a: GO:0005884 ! actin filament intersection_of: GO:0005884 ! actin filament intersection_of: part_of GO:0042641 ! actomyosin relationship: part_of GO:0042641 ! actomyosin [Term] id: GO:0042644 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0042646 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0042647 name: proplastid nucleoid namespace: cellular_component def: "The region of a proplastid to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0009537 ! proplastid relationship: part_of GO:0009571 ! proplastid stroma [Term] id: GO:0042648 name: chloroplast chromosome namespace: cellular_component def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] is_a: GO:0009508 ! plastid chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0042644 ! chloroplast nucleoid [Term] id: GO:0042649 name: prothylakoid namespace: cellular_component def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175] is_a: GO:0031976 ! plastid thylakoid relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0042650 name: prothylakoid membrane namespace: cellular_component def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0042649 ! prothylakoid [Term] id: GO:0042651 name: thylakoid membrane namespace: cellular_component def: "The pigmented membrane of any thylakoid." [GOC:jl, GOC:pr] is_a: GO:0034357 ! photosynthetic membrane [Term] id: GO:0042652 name: mitochondrial respiratory chain complex I, peripheral segment namespace: cellular_component def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD [] synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I [Term] id: GO:0042653 name: mitochondrial respiratory chain complex I, membrane segment namespace: cellular_component def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I [Term] id: GO:0042654 name: ecdysis-triggering hormone receptor activity namespace: molecular_function def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] synonym: "ecdysis-triggering hormone binding" NARROW [] synonym: "ETH receptor" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity relationship: has_part GO:0042562 ! hormone binding [Term] id: GO:0042655 name: activation of JNKKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf] synonym: "activation of JUN kinase kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKKK activity" BROAD [] is_a: GO:0000185 ! activation of MAPKKK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade relationship: positively_regulates GO:0004706 ! JUN kinase kinase kinase activity [Term] id: GO:0042656 name: JUN kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf] synonym: "JUNKKKK activity" EXACT [] is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity relationship: part_of GO:0042655 ! activation of JNKKK activity [Term] id: GO:0042657 name: MHC class II protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT [] is_a: GO:0042289 ! MHC class II protein binding [Term] id: GO:0042658 name: MHC class II protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl] synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT [] is_a: GO:0042289 ! MHC class II protein binding relationship: part_of GO:0023026 ! MHC class II protein complex binding [Term] id: GO:0042659 name: regulation of cell fate specification namespace: biological_process def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] is_a: GO:0010453 ! regulation of cell fate commitment intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001708 ! cell fate specification relationship: regulates GO:0001708 ! cell fate specification [Term] id: GO:0042660 name: positive regulation of cell fate specification namespace: biological_process def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators] synonym: "activation of cell fate specification" NARROW [] synonym: "stimulation of cell fate specification" NARROW [] synonym: "up regulation of cell fate specification" EXACT [] synonym: "up-regulation of cell fate specification" EXACT [] synonym: "upregulation of cell fate specification" EXACT [] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0042659 ! regulation of cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001708 ! cell fate specification relationship: positively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0042661 name: regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1905770 ! regulation of mesodermal cell differentiation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007501 ! mesodermal cell fate specification relationship: regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0042662 name: negative regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] synonym: "down regulation of mesodermal cell fate specification" EXACT [] synonym: "down-regulation of mesodermal cell fate specification" EXACT [] synonym: "downregulation of mesodermal cell fate specification" EXACT [] synonym: "inhibition of mesodermal cell fate specification" NARROW [] synonym: "suppression of mesodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042661 ! regulation of mesodermal cell fate specification is_a: GO:1905771 ! negative regulation of mesodermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007501 ! mesodermal cell fate specification relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0042663 name: regulation of endodermal cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators] synonym: "regulation of endoderm cell fate specification" EXACT [] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001714 ! endodermal cell fate specification relationship: regulates GO:0001714 ! endodermal cell fate specification [Term] id: GO:0042664 name: negative regulation of endodermal cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators] synonym: "down regulation of endodermal cell fate specification" EXACT [] synonym: "down-regulation of endodermal cell fate specification" EXACT [] synonym: "downregulation of endodermal cell fate specification" EXACT [] synonym: "inhibition of endodermal cell fate specification" NARROW [] synonym: "negative regulation of endoderm cell fate specification" EXACT [] synonym: "suppression of endoderm cell fate" EXACT [] synonym: "suppression of endodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042663 ! regulation of endodermal cell fate specification is_a: GO:1903225 ! negative regulation of endodermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001714 ! endodermal cell fate specification relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification [Term] id: GO:0042665 name: regulation of ectodermal cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators] synonym: "regulation of ectoderm cell fate specification" EXACT [] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001715 ! ectodermal cell fate specification relationship: regulates GO:0001715 ! ectodermal cell fate specification [Term] id: GO:0042666 name: negative regulation of ectodermal cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators] synonym: "down regulation of ectodermal cell fate specification" EXACT [] synonym: "down-regulation of ectodermal cell fate specification" EXACT [] synonym: "downregulation of ectodermal cell fate specification" EXACT [] synonym: "inhibition of ectodermal cell fate specification" NARROW [] synonym: "negative regulation of ectoderm cell fate specification" EXACT [] synonym: "suppression of ectoderm cell fate" EXACT [] synonym: "suppression of ectodermal cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042665 ! regulation of ectodermal cell fate specification is_a: GO:2000384 ! negative regulation of ectoderm development is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001715 ! ectodermal cell fate specification relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification [Term] id: GO:0042667 name: auditory receptor cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "auditory hair cell fate specification" EXACT [] is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0009912 ! auditory receptor cell fate commitment [Term] id: GO:0042668 name: auditory receptor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "auditory hair cell fate determination" EXACT [] is_a: GO:0048664 ! neuron fate determination relationship: part_of GO:0009912 ! auditory receptor cell fate commitment [Term] id: GO:0042669 name: regulation of inner ear auditory receptor cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators] synonym: "regulation of auditory hair cell fate specification" EXACT [] synonym: "regulation of inner ear auditory receptor cell fate specification" RELATED [] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042667 ! auditory receptor cell fate specification relationship: regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0042670 name: retinal cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0042671 name: retinal cone cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0043703 ! photoreceptor cell fate determination relationship: part_of GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0042672 name: retinal cone cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] is_a: GO:0043704 ! photoreceptor cell fate specification relationship: part_of GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0042673 name: regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0060222 ! regulation of retinal cone cell fate commitment intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042672 ! retinal cone cell fate specification relationship: regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0042675 name: compound eye cone cell differentiation namespace: biological_process alt_id: GO:0042674 def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0042676 name: compound eye cone cell fate commitment namespace: biological_process alt_id: GO:0007466 def: "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0042675 ! compound eye cone cell differentiation [Term] id: GO:0042679 name: compound eye cone cell fate specification namespace: biological_process alt_id: GO:0042678 def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0042676 ! compound eye cone cell fate commitment [Term] id: GO:0042680 name: compound eye cone cell fate determination namespace: biological_process alt_id: GO:0042677 def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042676 ! compound eye cone cell fate commitment [Term] id: GO:0042682 name: regulation of compound eye cone cell fate specification namespace: biological_process alt_id: GO:0042681 def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042679 ! compound eye cone cell fate specification relationship: regulates GO:0042679 ! compound eye cone cell fate specification [Term] id: GO:0042683 name: negative regulation of compound eye cone cell fate specification namespace: biological_process alt_id: GO:0010000 def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] synonym: "down regulation of cone cell fate specification" BROAD [] synonym: "down-regulation of cone cell fate specification" BROAD [] synonym: "downregulation of cone cell fate specification" BROAD [] synonym: "inhibition of cone cell fate specification" BROAD [] synonym: "suppression of cone cell fate" BROAD [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042682 ! regulation of compound eye cone cell fate specification is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042679 ! compound eye cone cell fate specification relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification [Term] id: GO:0042684 name: cardioblast cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0010002 ! cardioblast differentiation [Term] id: GO:0042685 name: cardioblast cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060912 ! cardiac cell fate specification relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0042686 name: regulation of cardioblast cell fate specification namespace: biological_process def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:2000043 ! regulation of cardiac cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042685 ! cardioblast cell fate specification relationship: regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0042688 name: crystal cell differentiation namespace: biological_process def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] is_a: GO:0042386 ! hemocyte differentiation [Term] id: GO:0042689 name: regulation of crystal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042688 ! crystal cell differentiation relationship: regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042690 name: negative regulation of crystal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "down regulation of crystal cell differentiation" EXACT [] synonym: "down-regulation of crystal cell differentiation" EXACT [] synonym: "downregulation of crystal cell differentiation" EXACT [] synonym: "inhibition of crystal cell differentiation" NARROW [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045611 ! negative regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042688 ! crystal cell differentiation relationship: negatively_regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042691 name: positive regulation of crystal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] synonym: "activation of crystal cell differentiation" NARROW [] synonym: "stimulation of crystal cell differentiation" NARROW [] synonym: "up regulation of crystal cell differentiation" EXACT [] synonym: "up-regulation of crystal cell differentiation" EXACT [] synonym: "upregulation of crystal cell differentiation" EXACT [] is_a: GO:0042689 ! regulation of crystal cell differentiation is_a: GO:0045612 ! positive regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042688 ! crystal cell differentiation relationship: positively_regulates GO:0042688 ! crystal cell differentiation [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] synonym: "myogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0061061 ! muscle structure development [Term] id: GO:0042693 name: muscle cell fate commitment namespace: biological_process def: "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0042692 ! muscle cell differentiation [Term] id: GO:0042694 name: muscle cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0042695 name: thelarche namespace: biological_process def: "The beginning of development of the breasts in the female." [GOC:curators, PMID:19117864] xref: Wikipedia:Thelarche is_a: GO:0046543 ! development of secondary female sexual characteristics relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0042696 name: menarche namespace: biological_process def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040] subset: gocheck_do_not_annotate xref: Wikipedia:Menarche is_a: GO:0022601 ! menstrual cycle phase [Term] id: GO:0042697 name: menopause namespace: biological_process def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681] subset: gocheck_do_not_annotate xref: Wikipedia:Menopause is_a: GO:0022601 ! menstrual cycle phase relationship: part_of GO:0010259 ! multicellular organism aging [Term] id: GO:0042698 name: ovulation cycle namespace: biological_process def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544] is_a: GO:0048511 ! rhythmic process is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0042699 name: follicle-stimulating hormone signaling pathway namespace: biological_process def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph] synonym: "follicle stimulating hormone signaling pathway" EXACT [] synonym: "follicle stimulating hormone signalling pathway" EXACT [] synonym: "follicle-stimulating hormone signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0042700 name: luteinizing hormone signaling pathway namespace: biological_process def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph] synonym: "luteinizing hormone signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0042701 name: progesterone secretion namespace: biological_process def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] is_a: GO:0015893 ! drug transport is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0035929 ! steroid hormone secretion relationship: part_of GO:0001553 ! luteinization [Term] id: GO:0042702 name: uterine wall growth namespace: biological_process def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001553 ! luteinization [Term] id: GO:0042703 name: menstruation namespace: biological_process def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059] subset: gocheck_do_not_annotate xref: Wikipedia:Menstruation is_a: GO:0022601 ! menstrual cycle phase [Term] id: GO:0042704 name: uterine wall breakdown namespace: biological_process def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph] is_a: GO:0022602 ! ovulation cycle process relationship: happens_during GO:0042703 ! menstruation [Term] id: GO:0042705 name: ocellus photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0042706 name: eye photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0046552 ! photoreceptor cell fate commitment relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation [Term] id: GO:0042707 name: ocellus photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0046552 ! photoreceptor cell fate commitment relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation [Term] id: GO:0042708 name: obsolete elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "elastase activity" EXACT [] is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0042709 name: succinate-CoA ligase complex namespace: cellular_component def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0042710 name: biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229] subset: gocheck_do_not_annotate subset: gocheck_do_not_manually_annotate subset: goslim_candida subset: goslim_pir xref: MIPS_funcat:43.01.02.13 is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0042711 name: maternal behavior namespace: biological_process def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators] synonym: "maternal behaviour" EXACT [] is_a: GO:0060746 ! parental behavior [Term] id: GO:0042712 name: paternal behavior namespace: biological_process def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators] synonym: "paternal behaviour" EXACT [] is_a: GO:0060746 ! parental behavior [Term] id: GO:0042713 name: sperm ejaculation namespace: biological_process def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination [Term] id: GO:0042714 name: dosage compensation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007549 ! dosage compensation [Term] id: GO:0042715 name: dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493] synonym: "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome" RELATED [GOC:dph, GOC:tb] is_a: GO:0042714 ! dosage compensation complex assembly is_a: GO:0065004 ! protein-DNA complex assembly intersection_of: GO:0042714 ! dosage compensation complex assembly intersection_of: part_of GO:0042464 ! dosage compensation by hypoactivation of X chromosome relationship: part_of GO:0042464 ! dosage compensation by hypoactivation of X chromosome [Term] id: GO:0042716 name: plasma membrane-derived chromatophore namespace: cellular_component def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431] comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. synonym: "chromatophore vesicle" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0042717 name: plasma membrane-derived chromatophore membrane namespace: cellular_component def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431] is_a: GO:0034357 ! photosynthetic membrane relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0042718 name: yolk granule namespace: cellular_component def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm, PMID:18046696] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060417 ! yolk [Term] id: GO:0042719 name: mitochondrial intermembrane space protein transporter complex namespace: cellular_component def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] synonym: "Tim9-Tim10 complex" NARROW [] is_a: GO:0098798 ! mitochondrial protein complex is_a: GO:1990351 ! transporter complex relationship: part_of GO:0005758 ! mitochondrial intermembrane space [Term] id: GO:0042720 name: mitochondrial inner membrane peptidase complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769] synonym: "IMP" NARROW [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0042721 name: TIM22 mitochondrial import inner membrane insertion complex namespace: cellular_component def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12." [PMID:12191765, PMID:27554484] synonym: "mitochondrial inner membrane protein insertion complex" EXACT [] synonym: "mitochondrial protein translocase complex" BROAD [] synonym: "Tim22 complex" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0042722 name: alpha-beta T cell activation by superantigen namespace: biological_process def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl] synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT [] synonym: "alpha-beta T-cell activation by superantigen" EXACT [] synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT [] is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0042723 name: thiamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [GOC:jl] synonym: "thiamin and derivative metabolic process" EXACT [] synonym: "thiamin and derivative metabolism" EXACT [] synonym: "thiamin-containing compound metabolic process" EXACT [] synonym: "thiamine and derivative metabolic process" EXACT [] synonym: "thiamine and derivative metabolism" EXACT [] synonym: "thiamine-containing compound metabolism" EXACT [] synonym: "vitamin B1 and derivative metabolic process" EXACT [] synonym: "vitamin B1 and derivative metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0042724 name: thiamine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [GOC:jl] synonym: "thiamin and derivative biosynthesis" EXACT [] synonym: "thiamin and derivative biosynthetic process" EXACT [] synonym: "thiamin-containing compound biosynthetic process" EXACT [] synonym: "thiamine and derivative biosynthesis" EXACT [] synonym: "thiamine and derivative biosynthetic process" EXACT [] synonym: "thiamine-containing compound anabolism" EXACT [] synonym: "thiamine-containing compound biosynthesis" EXACT [] synonym: "thiamine-containing compound formation" EXACT [] synonym: "thiamine-containing compound synthesis" EXACT [] synonym: "vitamin B1 and derivative biosynthesis" EXACT [] synonym: "vitamin B1 and derivative biosynthetic process" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042723 ! thiamine-containing compound metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0042725 name: thiamine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [GOC:jl] synonym: "thiamin and derivative catabolic process" EXACT [] synonym: "thiamin and derivative catabolism" EXACT [] synonym: "thiamin-containing compound catabolic process" EXACT [] synonym: "thiamine and derivative catabolic process" EXACT [] synonym: "thiamine and derivative catabolism" EXACT [] synonym: "thiamine-containing compound breakdown" EXACT [] synonym: "thiamine-containing compound catabolism" EXACT [] synonym: "thiamine-containing compound degradation" EXACT [] synonym: "vitamin B1 and derivative catabolic process" EXACT [] synonym: "vitamin B1 and derivative catabolism" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042723 ! thiamine-containing compound metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0042726 name: flavin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] synonym: "flavin-containing compound metabolism" EXACT [] synonym: "riboflavin and derivative metabolic process" RELATED [] synonym: "riboflavin and derivative metabolism" RELATED [] synonym: "vitamin B2 and derivative metabolic process" RELATED [] synonym: "vitamin B2 and derivative metabolism" RELATED [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042727 name: flavin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] synonym: "flavin-containing compound anabolism" EXACT [] synonym: "flavin-containing compound biosynthesis" EXACT [] synonym: "flavin-containing compound formation" EXACT [] synonym: "flavin-containing compound synthesis" EXACT [] synonym: "riboflavin and derivative biosynthesis" RELATED [] synonym: "riboflavin and derivative biosynthetic process" RELATED [] synonym: "vitamin B2 and derivative biosynthesis" RELATED [] synonym: "vitamin B2 and derivative biosynthetic process" RELATED [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042726 ! flavin-containing compound metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042728 name: flavin-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] synonym: "flavin-containing compound catabolic process breakdown" EXACT [] synonym: "flavin-containing compound catabolic process degradation" EXACT [] synonym: "flavin-containing compound catabolism" EXACT [] synonym: "riboflavin and derivative catabolic process" RELATED [] synonym: "riboflavin and derivative catabolism" RELATED [] synonym: "vitamin B2 and derivative catabolic process" RELATED [] synonym: "vitamin B2 and derivative catabolism" RELATED [] is_a: GO:0042726 ! flavin-containing compound metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042729 name: DASH complex namespace: cellular_component alt_id: GO:0043925 alt_id: GO:0043926 def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:vw, http://www.wikigenes.org/e/gene/e/853090.html, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796] comment: Note that this complex is conserved in fungi but has not been observed in metazoans. synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT [] synonym: "Dam1 complex" EXACT [] synonym: "DDD complex" EXACT [] synonym: "Duo1p-Dam1p-Dad1p complex" EXACT [] is_a: GO:0000942 ! condensed nuclear chromosome outer kinetochore [Term] id: GO:0042730 name: fibrinolysis namespace: biological_process def: "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." [GOC:jl, PMID:15842654] xref: Wikipedia:Fibrinolysis is_a: GO:0030195 ! negative regulation of blood coagulation [Term] id: GO:0042731 name: PH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0042732 name: D-xylose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] synonym: "D-xylose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0042733 name: embryonic digit morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0030326 ! embryonic limb morphogenesis [Term] id: GO:0042734 name: presynaptic membrane namespace: cellular_component def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194] subset: goslim_synapse synonym: "pre-synaptic membrane" EXACT [] synonym: "presynaptic plasma membrane" EXACT [] is_a: GO:0097060 ! synaptic membrane relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0042735 name: protein body namespace: cellular_component def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0042736 name: NADH kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12260] synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86] synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86] synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86] xref: EC:2.7.1.86 xref: KEGG_REACTION:R00105 xref: MetaCyc:NADH-KINASE-RXN xref: RHEA:12260 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0042737 name: drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators] synonym: "drug breakdown" EXACT [] synonym: "drug catabolism" EXACT [] synonym: "drug degradation" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042738 name: exogenous drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl] synonym: "exogenous drug breakdown" EXACT [] synonym: "exogenous drug catabolism" EXACT [] synonym: "exogenous drug degradation" EXACT [] is_a: GO:0042737 ! drug catabolic process relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0042739 name: endogenous drug catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl] synonym: "endogenous drug breakdown" EXACT [] synonym: "endogenous drug catabolism" EXACT [] synonym: "endogenous drug degradation" EXACT [] is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042740 name: exogenous antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl] synonym: "exogenous antibiotic breakdown" EXACT [] synonym: "exogenous antibiotic catabolism" EXACT [] synonym: "exogenous antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042738 ! exogenous drug catabolic process relationship: part_of GO:0046677 ! response to antibiotic [Term] id: GO:0042741 name: endogenous antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl] synonym: "endogenous antibiotic breakdown" EXACT [] synonym: "endogenous antibiotic catabolism" EXACT [] synonym: "endogenous antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042739 ! endogenous drug catabolic process [Term] id: GO:0042742 name: defense response to bacterium namespace: biological_process alt_id: GO:0042830 def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] synonym: "antibacterial peptide activity" RELATED [] synonym: "defence response to bacteria" EXACT [] synonym: "defence response to bacterium" EXACT [] synonym: "defense response to bacteria" EXACT [] is_a: GO:0009617 ! response to bacterium is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0042743 name: hydrogen peroxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/] synonym: "H2O2 metabolic process" EXACT [GOC:mah] synonym: "hydrogen peroxide metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0042744 name: hydrogen peroxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] synonym: "detoxification of H2O2" RELATED [GOC:vw] synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw] synonym: "H2O2 catabolic process" EXACT [GOC:mah] synonym: "H2O2 scavenging" RELATED [GOC:vw] synonym: "hydrogen peroxide breakdown" EXACT [] synonym: "hydrogen peroxide catabolism" EXACT [] synonym: "hydrogen peroxide degradation" EXACT [] synonym: "hydrogen peroxide removal" RELATED [] synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0042745 name: circadian sleep/wake cycle namespace: biological_process def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] is_a: GO:0048512 ! circadian behavior [Term] id: GO:0042746 name: circadian sleep/wake cycle, wakefulness namespace: biological_process def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468] is_a: GO:0022410 ! circadian sleep/wake cycle process [Term] id: GO:0042747 name: circadian sleep/wake cycle, REM sleep namespace: biological_process def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042748 name: circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com] is_a: GO:0022410 ! circadian sleep/wake cycle process relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0042749 name: regulation of circadian sleep/wake cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042745 ! circadian sleep/wake cycle relationship: regulates GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0042750 name: hibernation namespace: biological_process def: "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046] xref: Wikipedia:Hibernation is_a: GO:0022611 ! dormancy process is_a: GO:0030431 ! sleep [Term] id: GO:0042751 name: estivation namespace: biological_process def: "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, PMID:12443930, Wikipedia:Estivation] synonym: "aestivation" EXACT [GOC:pr] xref: Wikipedia:Estivation is_a: GO:0022611 ! dormancy process is_a: GO:0030431 ! sleep [Term] id: GO:0042752 name: regulation of circadian rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007623 ! circadian rhythm relationship: regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042753 name: positive regulation of circadian rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "activation of circadian rhythm" NARROW [] synonym: "stimulation of circadian rhythm" NARROW [] synonym: "up regulation of circadian rhythm" EXACT [] synonym: "up-regulation of circadian rhythm" EXACT [] synonym: "upregulation of circadian rhythm" EXACT [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007623 ! circadian rhythm relationship: positively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042754 name: negative regulation of circadian rhythm namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] synonym: "down regulation of circadian rhythm" EXACT [] synonym: "down-regulation of circadian rhythm" EXACT [] synonym: "downregulation of circadian rhythm" EXACT [] synonym: "inhibition of circadian rhythm" NARROW [] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007623 ! circadian rhythm relationship: negatively_regulates GO:0007623 ! circadian rhythm [Term] id: GO:0042755 name: eating behavior namespace: biological_process def: "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, PMID:19361967] synonym: "eating behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042756 name: drinking behavior namespace: biological_process def: "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr] synonym: "drinking behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior [Term] id: GO:0042757 name: giant axon namespace: cellular_component def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477] is_a: GO:0030424 ! axon [Term] id: GO:0042758 name: long-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22." [PMID:20043225] synonym: "long-chain fatty acid breakdown" EXACT [] synonym: "long-chain fatty acid catabolism" EXACT [] synonym: "long-chain fatty acid degradation" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0009062 ! fatty acid catabolic process [Term] id: GO:0042759 name: long-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [PMID:18390550] synonym: "long-chain fatty acid anabolism" EXACT [] synonym: "long-chain fatty acid biosynthesis" EXACT [] synonym: "long-chain fatty acid formation" EXACT [] synonym: "long-chain fatty acid synthesis" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042760 name: very long-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [PMID:7744868] synonym: "very-long-chain fatty acid breakdown" EXACT [] synonym: "very-long-chain fatty acid catabolic process" EXACT [] synonym: "very-long-chain fatty acid catabolism" EXACT [] synonym: "very-long-chain fatty acid degradation" EXACT [] is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0009062 ! fatty acid catabolic process [Term] id: GO:0042761 name: very long-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [PMID:7744868] synonym: "very-long-chain fatty acid anabolism" EXACT [] synonym: "very-long-chain fatty acid biosynthesis" EXACT [] synonym: "very-long-chain fatty acid biosynthetic process" EXACT [] synonym: "very-long-chain fatty acid formation" EXACT [] synonym: "very-long-chain fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-5080 is_a: GO:0000038 ! very long-chain fatty acid metabolic process is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0042762 name: regulation of sulfur metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] synonym: "regulation of sulfur metabolism" EXACT [] synonym: "regulation of sulphur metabolic process" EXACT [] synonym: "regulation of sulphur metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006790 ! sulfur compound metabolic process relationship: regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0042763 name: intracellular immature spore namespace: cellular_component def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] synonym: "forespore" RELATED [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0042764 name: ascospore-type prospore namespace: cellular_component def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators] is_a: GO:0042763 ! intracellular immature spore [Term] id: GO:0042765 name: GPI-anchor transamidase complex namespace: cellular_component def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. synonym: "GPIT complex" EXACT [] is_a: GO:0098796 ! membrane protein complex is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane [Term] id: GO:0042766 name: nucleosome mobilization namespace: biological_process def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495] synonym: "nucleosome sliding" EXACT [GOC:dph] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0042767 name: ecdysteroid 22-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0042768 name: ecdysteroid 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427] comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0042769 name: DNA damage response, detection of DNA damage namespace: biological_process def: "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators] synonym: "detection of DNA damage during DNA damage response" EXACT [] synonym: "DNA damage response, perception of DNA damage" RELATED [] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0042770 name: signal transduction in response to DNA damage namespace: biological_process def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] synonym: "DNA damage response, signal transduction" EXACT [] synonym: "response to DNA damage stimulus by intracellular signaling cascade" EXACT [GOC:dph, GOC:tb] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0042771 name: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [] is_a: GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator [Term] id: GO:0042772 name: DNA damage response, signal transduction resulting in transcription namespace: biological_process def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators] is_a: GO:0042770 ! signal transduction in response to DNA damage [Term] id: GO:0042773 name: ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0006119 ! oxidative phosphorylation [Term] id: GO:0042774 name: plasma membrane ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: occurs_in GO:0005886 ! plasma membrane relationship: occurs_in GO:0005886 ! plasma membrane [Term] id: GO:0042775 name: mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363] synonym: "mitochondrial electron transport" BROAD [] synonym: "organelle ATP synthesis coupled electron transport" BROAD [] is_a: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0042776 name: mitochondrial ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] synonym: "mitochondrial proton transport" BROAD [] is_a: GO:0006119 ! oxidative phosphorylation is_a: GO:0015986 ! ATP synthesis coupled proton transport is_a: GO:0046907 ! intracellular transport is_a: GO:1990542 ! mitochondrial transmembrane transport intersection_of: GO:0015986 ! ATP synthesis coupled proton transport intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0042777 name: plasma membrane ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] synonym: "ATP synthesis coupled proton transport" BROAD [] is_a: GO:0015986 ! ATP synthesis coupled proton transport [Term] id: GO:0042778 name: tRNA end turnover namespace: biological_process def: "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators] is_a: GO:0006399 ! tRNA metabolic process [Term] id: GO:0042779 name: tRNA 3'-trailer cleavage namespace: biological_process def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators] synonym: "removal of tRNA 3'-trailer sequence" EXACT [] synonym: "tRNA 3'-end cleavage" EXACT [] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis relationship: part_of GO:0042780 ! tRNA 3'-end processing [Term] id: GO:0042780 name: tRNA 3'-end processing namespace: biological_process def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] synonym: "tRNA 3' processing" EXACT [] is_a: GO:0008033 ! tRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0042781 name: 3'-tRNA processing endoribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11] synonym: "3 tRNase activity" EXACT [EC:3.1.26.11] synonym: "3' tRNA processing endoribonuclease activity" EXACT [] synonym: "3' tRNase activity" EXACT [] synonym: "ribonuclease Z activity" BROAD [] synonym: "RNase Z activity" BROAD [] synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11] synonym: "tRNA 3' endonuclease activity" EXACT [] synonym: "tRNAse Z" RELATED [EC:3.1.26.11] xref: MetaCyc:3.1.26.11-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters relationship: part_of GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic [Term] id: GO:0042783 name: evasion of host immune response namespace: biological_process alt_id: GO:0042782 alt_id: GO:0051809 alt_id: GO:0051810 def: "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: Merged terms as requested: https://github.com/geneontology/go-ontology/issues/17894. synonym: "active evasion of host immune response" RELATED [] synonym: "active evasion of immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "active immune evasion" BROAD [] synonym: "passive evasion of host immune response" RELATED [] synonym: "passive evasion of immune response of other organism involved in symbiotic interaction" RELATED [] synonym: "passive immune evasion" RELATED [] is_a: GO:0020012 ! mitigation of host immune response [Term] id: GO:0042784 name: evasion of host immune response via regulation of host complement system namespace: biological_process alt_id: GO:0051811 def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] synonym: "active evasion of host immune response via regulation of host complement system" RELATED [] synonym: "active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction" BROAD [] synonym: "active immune evasion via modulation of host complement system" EXACT [] synonym: "active immune evasion via regulation of host complement system" EXACT [] is_a: GO:0042783 ! evasion of host immune response [Term] id: GO:0042785 name: evasion of host immune response via regulation of host cytokine network namespace: biological_process alt_id: GO:0051812 def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] synonym: "active evasion of host immune response via regulation of host cytokine network" RELATED [] synonym: "active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction" BROAD [] synonym: "active immune evasion via modulation of host cytokine network" EXACT [] synonym: "active immune evasion via regulation of host cytokine network" EXACT [] is_a: GO:0042783 ! evasion of host immune response [Term] id: GO:0042786 name: evasion of host immune response via regulation of host antigen processing and presentation namespace: biological_process alt_id: GO:0051813 def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] synonym: "active evasion of host immune response via regulation of host antigen processing and presentation" RELATED [] synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT [] synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction" BROAD [] synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT [] synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT [] synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT [] is_a: GO:0042783 ! evasion of host immune response [Term] id: GO:0042788 name: polysomal ribosome namespace: cellular_component def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl] synonym: "active ribosome" BROAD [] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0005844 ! polysome relationship: part_of GO:0005844 ! polysome [Term] id: GO:0042789 name: mRNA transcription by RNA polymerase II namespace: biological_process def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "mRNA transcription from Pol II promoter" EXACT [] synonym: "mRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0009299 ! mRNA transcription [Term] id: GO:0042790 name: nucleolar large rRNA transcription by RNA polymerase I namespace: biological_process def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT [] synonym: "transcription of nucleolar large rRNA by RNA polymerase I" EXACT [] is_a: GO:0006360 ! transcription by RNA polymerase I is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042791 name: 5S class rRNA transcription by RNA polymerase III namespace: biological_process def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659] synonym: "5S class rRNA transcription from RNA polymerase III type 1 promoter" RELATED [] synonym: "5S rRNA transcription" EXACT [] is_a: GO:0006383 ! transcription by RNA polymerase III is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042792 name: mitochondrial rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382] synonym: "rRNA transcription from mitochondrial promoter" EXACT [] is_a: GO:0006390 ! mitochondrial transcription is_a: GO:0009303 ! rRNA transcription [Term] id: GO:0042793 name: plastid transcription namespace: biological_process def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from plastid promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0042794 name: plastid rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "rRNA transcription from plastid promoter" EXACT [] is_a: GO:0009303 ! rRNA transcription is_a: GO:0042793 ! plastid transcription [Term] id: GO:0042795 name: snRNA transcription by RNA polymerase II namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "snRNA transcription from Pol II promoter" EXACT [] synonym: "snRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0009301 ! snRNA transcription [Term] id: GO:0042796 name: snRNA transcription by RNA polymerase III namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "snRNA transcription from Pol III promoter" EXACT [] synonym: "snRNA transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006383 ! transcription by RNA polymerase III is_a: GO:0009301 ! snRNA transcription [Term] id: GO:0042797 name: tRNA transcription by RNA polymerase III namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "tRNA transcription from Pol III promoter" EXACT [] synonym: "tRNA transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006383 ! transcription by RNA polymerase III is_a: GO:0009304 ! tRNA transcription [Term] id: GO:0042798 name: obsolete protein neddylation during NEDD8 class-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl] comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT [] synonym: "protein neddylation during NEDD8 class-dependent protein catabolic process" EXACT [] synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT [] synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT [] synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT [] synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT [] is_obsolete: true consider: GO:0045116 [Term] id: GO:0042799 name: histone methyltransferase activity (H4-K20 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT [] synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT [] synonym: "histone methylase activity (H4-K20 specific)" EXACT [GOC:mah] xref: Reactome:R-HSA-2301205 "SETD8 monomethylates histone H4" xref: Reactome:R-HSA-5682965 "WHSC1 dimethylates histone H4 on lysine K21 at DSBs" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0042800 name: histone methyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT [] synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah] xref: Reactome:R-HSA-1214188 "PRDM9 trimethylates histone H3" xref: Reactome:R-HSA-3364026 "SET1 complex trimethylates H3K4 at the MYC gene" xref: Reactome:R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark" xref: Reactome:R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter" xref: Reactome:R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter" xref: Reactome:R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter" xref: Reactome:R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0042801 name: obsolete polo kinase kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma] comment: This term was made obsolete because it represents a gene product and also refers to a non-existent activity (polo kinase). is_obsolete: true [Term] id: GO:0042802 name: identical protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] subset: goslim_chembl synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655] synonym: "protein homopolymerization" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042803 name: protein homodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] subset: goslim_chembl synonym: "dimerization activity" BROAD [] is_a: GO:0042802 ! identical protein binding is_a: GO:0046983 ! protein dimerization activity [Term] id: GO:0042804 name: obsolete protein homooligomerization activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl] comment: This term was made obsolete because it represents a biological process. synonym: "oligomerization activity" BROAD [] synonym: "protein homooligomerization activity" EXACT [] is_obsolete: true replaced_by: GO:0051260 [Term] id: GO:0042805 name: actinin binding namespace: molecular_function alt_id: GO:0051406 def: "Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732] synonym: "beta-actinin binding" NARROW [] synonym: "capZ binding" EXACT [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0042806 name: fucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [ISBN:0582227089] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0042807 name: central vacuole namespace: cellular_component def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [ISBN:9780815341116, Wikipedia:Vacuole] is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0042808 name: obsolete neuronal Cdc2-like kinase binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "neuronal Cdc2-like kinase binding" EXACT [] is_obsolete: true replaced_by: GO:0019901 [Term] id: GO:0042809 name: vitamin D receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589] synonym: "calciferol receptor binding" NARROW [] synonym: "VDR binding" EXACT [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0042810 name: pheromone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] subset: goslim_pir synonym: "pheromone metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0042811 name: pheromone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] synonym: "pheromone anabolism" EXACT [] synonym: "pheromone biosynthesis" EXACT [] synonym: "pheromone formation" EXACT [] synonym: "pheromone synthesis" EXACT [] is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process [Term] id: GO:0042812 name: pheromone catabolic process namespace: biological_process alt_id: GO:0007327 alt_id: GO:0046614 def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] synonym: "pheromone breakdown" EXACT [] synonym: "pheromone catabolism" EXACT [] synonym: "pheromone degradation" EXACT [] is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042813 name: Wnt-activated receptor activity namespace: molecular_function def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators] subset: goslim_chembl synonym: "frizzled receptor activity" RELATED [] synonym: "frizzled-2 receptor activity" RELATED [] synonym: "Wnt receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: has_part GO:0017147 ! Wnt-protein binding relationship: part_of GO:0016055 ! Wnt signaling pathway [Term] id: GO:0042814 name: monopolar cell growth namespace: biological_process def: "Polarized growth from one end of a cell." [GOC:vw] synonym: "monopolar cell elongation" NARROW [] synonym: "monopolar growth" BROAD [] synonym: "polar cell elongation" NARROW [] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0042815 name: bipolar cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw] comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children. synonym: "bipolar cell elongation" NARROW [] synonym: "bipolar growth" BROAD [] synonym: "polar cell elongation" RELATED [] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0042816 name: vitamin B6 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "vitamin B6 metabolism" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0042817 name: pyridoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/] synonym: "pyridoxal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042818 name: pyridoxamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl] synonym: "pyridoxamine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042819 name: vitamin B6 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "pyridoxine-5'-phosphate biosynthesis" RELATED [GOC:yaf, UniPathway:UPA00244] synonym: "vitamin B6 anabolism" EXACT [] synonym: "vitamin B6 biosynthesis" EXACT [] synonym: "vitamin B6 formation" EXACT [] synonym: "vitamin B6 synthesis" EXACT [] is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0042820 name: vitamin B6 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "vitamin B6 breakdown" EXACT [] synonym: "vitamin B6 catabolism" EXACT [] synonym: "vitamin B6 degradation" EXACT [] is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0042821 name: pyridoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/] synonym: "pyridoxal anabolism" EXACT [] synonym: "pyridoxal biosynthesis" EXACT [] synonym: "pyridoxal formation" EXACT [] synonym: "pyridoxal synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042817 ! pyridoxal metabolic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042822 name: pyridoxal phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] synonym: "active vitamin B6 metabolic process" EXACT [] synonym: "active vitamin B6 metabolism" EXACT [] synonym: "pyridoxal phosphate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042823 name: pyridoxal phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] synonym: "active vitamin B6 biosynthesis" EXACT [] synonym: "active vitamin B6 biosynthetic process" EXACT [] synonym: "pyridoxal phosphate anabolism" EXACT [] synonym: "pyridoxal phosphate biosynthesis" EXACT [] synonym: "pyridoxal phosphate formation" EXACT [] synonym: "pyridoxal phosphate synthesis" EXACT [] xref: MetaCyc:PWY0-845 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042824 name: MHC class I peptide loading complex namespace: cellular_component def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. subset: goslim_pir synonym: "peptide-loading complex" EXACT [GOC:bhm] synonym: "PLC" RELATED [GOC:bhm] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane [Term] id: GO:0042825 name: TAP complex namespace: cellular_component def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934] synonym: "transporter associated with antigen presentation" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0042824 ! MHC class I peptide loading complex [Term] id: GO:0042826 name: histone deacetylase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0042827 name: platelet dense granule namespace: cellular_component def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378] synonym: "bull's eye body" EXACT [] synonym: "platelet dense body" EXACT [] is_a: GO:0030141 ! secretory granule [Term] id: GO:0042832 name: defense response to protozoan namespace: biological_process def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] synonym: "defence response to pathogenic protozoa" EXACT [] synonym: "defence response to protozoa" EXACT [] synonym: "defence response to protozoon" EXACT [] synonym: "defense response to pathogenic protozoa" EXACT [] synonym: "defense response to protozoa" EXACT [] synonym: "defense response to protozoon" EXACT [] is_a: GO:0001562 ! response to protozoan is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0042834 name: peptidoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0042835 name: BRE binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RNA element BRE (Bruno response element)." [PMID:10893231] is_a: GO:0003723 ! RNA binding [Term] id: GO:0042836 name: D-glucarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-glucarate metabolism" EXACT [] synonym: "saccharate metabolic process" EXACT [] synonym: "saccharate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0019392 ! glucarate metabolic process [Term] id: GO:0042837 name: D-glucarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-glucarate anabolism" EXACT [] synonym: "D-glucarate biosynthesis" EXACT [] synonym: "D-glucarate formation" EXACT [] synonym: "D-glucarate synthesis" EXACT [] synonym: "saccharate biosynthesis" EXACT [] synonym: "saccharate biosynthetic process" EXACT [] is_a: GO:0019393 ! glucarate biosynthetic process is_a: GO:0042836 ! D-glucarate metabolic process [Term] id: GO:0042838 name: D-glucarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-glucarate breakdown" EXACT [] synonym: "D-glucarate catabolism" EXACT [] synonym: "D-glucarate degradation" EXACT [] synonym: "saccharate catabolic process" EXACT [] synonym: "saccharate catabolism" EXACT [] is_a: GO:0019394 ! glucarate catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0042836 ! D-glucarate metabolic process [Term] id: GO:0042839 name: D-glucuronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] synonym: "D-glucuronate metabolism" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process [Term] id: GO:0042840 name: D-glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] synonym: "D-glucuronate breakdown" EXACT [] synonym: "D-glucuronate catabolism" EXACT [] synonym: "D-glucuronate degradation" EXACT [] is_a: GO:0006064 ! glucuronate catabolic process is_a: GO:0042839 ! D-glucuronate metabolic process [Term] id: GO:0042841 name: D-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] synonym: "D-glucuronate anabolism" EXACT [] synonym: "D-glucuronate biosynthesis" EXACT [] synonym: "D-glucuronate formation" EXACT [] synonym: "D-glucuronate synthesis" EXACT [] is_a: GO:0042839 ! D-glucuronate metabolic process is_a: GO:0046399 ! glucuronate biosynthetic process [Term] id: GO:0042842 name: D-xylose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] synonym: "D-xylose anabolism" EXACT [] synonym: "D-xylose biosynthesis" EXACT [] synonym: "D-xylose formation" EXACT [] synonym: "D-xylose synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0042732 ! D-xylose metabolic process [Term] id: GO:0042843 name: D-xylose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] synonym: "D-xylose breakdown" EXACT [] synonym: "D-xylose catabolism" EXACT [] synonym: "D-xylose degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0042732 ! D-xylose metabolic process [Term] id: GO:0042844 name: glycol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [PMID:9851711] synonym: "dihydric alcohol metabolic process" BROAD [] synonym: "dihydric alcohol metabolism" BROAD [] synonym: "glycol metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0042845 name: glycol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [GOC:curators] synonym: "dihydric alcohol biosynthesis" BROAD [] synonym: "dihydric alcohol biosynthetic process" BROAD [] synonym: "glycol anabolism" EXACT [] synonym: "glycol biosynthesis" EXACT [] synonym: "glycol formation" EXACT [] synonym: "glycol synthesis" EXACT [] is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042844 ! glycol metabolic process [Term] id: GO:0042846 name: glycol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [Wikipedia:Ethylene_glycol] synonym: "dihydric alcohol catabolic process" BROAD [] synonym: "dihydric alcohol catabolism" BROAD [] synonym: "glycol breakdown" EXACT [] synonym: "glycol catabolism" EXACT [] synonym: "glycol degradation" EXACT [] is_a: GO:0034313 ! diol catabolic process is_a: GO:0042844 ! glycol metabolic process [Term] id: GO:0042847 name: sorbose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] synonym: "sorbose anabolism" EXACT [] synonym: "sorbose biosynthesis" EXACT [] synonym: "sorbose formation" EXACT [] synonym: "sorbose synthesis" EXACT [] is_a: GO:0019311 ! sorbose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0042848 name: sorbose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] synonym: "sorbose breakdown" EXACT [] synonym: "sorbose catabolism" EXACT [] synonym: "sorbose degradation" EXACT [] is_a: GO:0019311 ! sorbose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0042849 name: L-sorbose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ISBN:0198506732] synonym: "L-sorbose anabolism" EXACT [] synonym: "L-sorbose biosynthesis" EXACT [] synonym: "L-sorbose formation" EXACT [] synonym: "L-sorbose synthesis" EXACT [] is_a: GO:0019312 ! L-sorbose metabolic process is_a: GO:0042847 ! sorbose biosynthetic process [Term] id: GO:0042850 name: L-sorbose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-sorbose breakdown" EXACT [] synonym: "L-sorbose catabolism" EXACT [] synonym: "L-sorbose degradation" EXACT [] is_a: GO:0019312 ! L-sorbose metabolic process is_a: GO:0042848 ! sorbose catabolic process [Term] id: GO:0042851 name: L-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] synonym: "L-alanine metabolism" EXACT [] is_a: GO:0006522 ! alanine metabolic process [Term] id: GO:0042852 name: L-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] synonym: "L-alanine anabolism" EXACT [] synonym: "L-alanine biosynthesis" EXACT [] synonym: "L-alanine formation" EXACT [] synonym: "L-alanine synthesis" EXACT [] is_a: GO:0006523 ! alanine biosynthetic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0042853 name: L-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] synonym: "L-alanine breakdown" EXACT [] synonym: "L-alanine catabolism" EXACT [] synonym: "L-alanine degradation" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0042854 name: eugenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT [] synonym: "4-allyl-2-methoxyphenol metabolism" EXACT [] synonym: "eugenic acid metabolic process" EXACT [] synonym: "eugenic acid metabolism" EXACT [] synonym: "eugenol metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0042855 name: eugenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT [] synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT [] synonym: "eugenic acid biosynthesis" EXACT [] synonym: "eugenic acid biosynthetic process" EXACT [] synonym: "eugenol anabolism" EXACT [] synonym: "eugenol biosynthesis" EXACT [] synonym: "eugenol formation" EXACT [] synonym: "eugenol synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0042854 ! eugenol metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0042856 name: eugenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT [] synonym: "4-allyl-2-methoxyphenol catabolism" EXACT [] synonym: "eugenic acid catabolic process" EXACT [] synonym: "eugenic acid catabolism" EXACT [] synonym: "eugenol breakdown" EXACT [] synonym: "eugenol catabolism" EXACT [] synonym: "eugenol degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042854 ! eugenol metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0042857 name: chrysobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] synonym: "chrysobactin metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0042858 name: chrysobactin biosynthetic process namespace: biological_process alt_id: GO:0031183 alt_id: GO:0031184 def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] synonym: "chrysobactin anabolism" EXACT [] synonym: "chrysobactin biosynthesis" EXACT [] synonym: "chrysobactin biosynthetic process, peptide formation" NARROW [] synonym: "chrysobactin biosynthetic process, peptide modification" NARROW [] synonym: "chrysobactin formation" EXACT [] synonym: "chrysobactin synthesis" EXACT [] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042857 ! chrysobactin metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process [Term] id: GO:0042859 name: chrysobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] synonym: "chrysobactin breakdown" EXACT [] synonym: "chrysobactin catabolism" EXACT [] synonym: "chrysobactin degradation" EXACT [] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042857 ! chrysobactin metabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0046215 ! siderophore catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0042860 name: achromobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] synonym: "achromobactin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0042861 name: achromobactin biosynthetic process namespace: biological_process alt_id: GO:0031181 alt_id: GO:0031182 def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] synonym: "achromobactin anabolism" EXACT [] synonym: "achromobactin biosynthesis" EXACT [] synonym: "achromobactin biosynthetic process, peptide formation" NARROW [] synonym: "achromobactin biosynthetic process, peptide modification" NARROW [] synonym: "achromobactin formation" EXACT [] synonym: "achromobactin synthesis" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0042860 ! achromobactin metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042862 name: achromobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] synonym: "achromobactin breakdown" EXACT [] synonym: "achromobactin catabolism" EXACT [] synonym: "achromobactin degradation" EXACT [] is_a: GO:0042860 ! achromobactin metabolic process is_a: GO:0046215 ! siderophore catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0042863 name: pyochelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] synonym: "pyochelin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0042864 name: pyochelin biosynthetic process namespace: biological_process alt_id: GO:0031187 alt_id: GO:0031188 def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] synonym: "pyochelin anabolism" EXACT [] synonym: "pyochelin biosynthesis" EXACT [] synonym: "pyochelin biosynthetic process, peptide formation" NARROW [] synonym: "pyochelin biosynthetic process, peptide modification" NARROW [] synonym: "pyochelin formation" EXACT [] synonym: "pyochelin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0042863 ! pyochelin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0042865 name: pyochelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] synonym: "pyochelin breakdown" EXACT [] synonym: "pyochelin catabolism" EXACT [] synonym: "pyochelin degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042863 ! pyochelin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046215 ! siderophore catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0042866 name: pyruvate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators] synonym: "pyruvate anabolism" EXACT [] synonym: "pyruvate biosynthesis" EXACT [] synonym: "pyruvate formation" EXACT [] synonym: "pyruvate synthesis" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0042867 name: pyruvate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators] synonym: "pyruvate breakdown" EXACT [] synonym: "pyruvate catabolism" EXACT [] synonym: "pyruvate degradation" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0042868 name: antisense RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl] synonym: "antisense RNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0042869 name: aldarate transmembrane transport namespace: biological_process def: "The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] synonym: "aldarate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0042870 name: D-glucarate transmembrane transport namespace: biological_process def: "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-glucarate transport" RELATED [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042869 ! aldarate transmembrane transport [Term] id: GO:0042873 name: aldonate transmembrane transport namespace: biological_process def: "The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] synonym: "aldonate transport" RELATED [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0042874 name: D-glucuronate transmembrane transport namespace: biological_process def: "The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah] synonym: "D-glucuronate transport" RELATED [] is_a: GO:0015738 ! glucuronate transmembrane transport [Term] id: GO:0042875 name: D-galactonate transmembrane transport namespace: biological_process def: "The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah] synonym: "D-galactonate transport" RELATED [] is_a: GO:0042873 ! aldonate transmembrane transport [Term] id: GO:0042876 name: aldarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aldarate from one side of a membrane to the other." [GOC:go_curators, PMID:15034926] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015144 ! carbohydrate transmembrane transporter activity relationship: part_of GO:0042869 ! aldarate transmembrane transport [Term] id: GO:0042878 name: D-glucarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0042876 ! aldarate transmembrane transporter activity relationship: part_of GO:0042870 ! D-glucarate transmembrane transport [Term] id: GO:0042879 name: aldonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aldonate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015144 ! carbohydrate transmembrane transporter activity relationship: part_of GO:0042873 ! aldonate transmembrane transport [Term] id: GO:0042880 name: D-glucuronate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015135 ! glucuronate transmembrane transporter activity relationship: part_of GO:0042874 ! D-glucuronate transmembrane transport [Term] id: GO:0042881 name: D-galactonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0042879 ! aldonate transmembrane transporter activity relationship: part_of GO:0042875 ! D-galactonate transmembrane transport [Term] id: GO:0042882 name: L-arabinose transmembrane transport namespace: biological_process def: "The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-arabinose transport" RELATED [] is_a: GO:0015751 ! arabinose transmembrane transport [Term] id: GO:0042883 name: cysteine transport namespace: biological_process def: "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] synonym: "L-cysteine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0042884 name: microcin transport namespace: biological_process def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337] is_a: GO:0015833 ! peptide transport [Term] id: GO:0042885 name: microcin B17 transport namespace: biological_process def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337] is_a: GO:0042884 ! microcin transport [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0042886 ! amide transport [Term] id: GO:0042888 name: molybdenum ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0042889 name: 3-phenylpropionic acid transport namespace: biological_process def: "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "3-phenylpropionate transport" EXACT [] synonym: "HCA transport" EXACT [] synonym: "hydrocinnamic acid transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0042890 name: 3-phenylpropionic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other." [GOC:jl] synonym: "3-phenylpropionate acid transporter activity" EXACT [] synonym: "HCA transporter activity" EXACT [] synonym: "hydrocinnamic acid transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0042889 ! 3-phenylpropionic acid transport [Term] id: GO:0042891 name: obsolete antibiotic transport namespace: biological_process def: "OBSOLETE. The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] comment: The reason for obsoletion is that this term has been inconsistently used. For export of an antibiotic by the organism that synthesizes it, consider 'GO:0140115 ; export across plasma membrane'. For export of an antibiotic by the target organism, consider GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane. See https://github.com/geneontology/go-ontology/issues/17082 for more details. is_obsolete: true [Term] id: GO:0042892 name: chloramphenicol transmembrane transport namespace: biological_process def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other." [PMID:29150447] synonym: "chloramphenicol transport" BROAD [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015791 ! polyol transport is_a: GO:0042886 ! amide transport [Term] id: GO:0042893 name: polymyxin transport namespace: biological_process def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0006869 ! lipid transport is_a: GO:0015833 ! peptide transport [Term] id: GO:0042894 name: fosmidomycin transport namespace: biological_process def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685] is_a: GO:0015711 ! organic anion transport is_a: GO:0042886 ! amide transport [Term] id: GO:0042895 name: obsolete antibiotic transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, from one side of a membrane to the other." [GOC:jl] comment: The reason for obsoletion is that this term has been inconsistently used. Consider annotating to 'GO:0042910 ; xenobiotic transmembrane transporter activity' and the specific solute being transported as an annotation extension. See https://github.com/geneontology/go-ontology/issues/17082 for more details. synonym: "antibiotic transporter activity" RELATED [] is_obsolete: true [Term] id: GO:0042896 name: chloramphenicol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other." [GOC:jl] synonym: "chloramphenicol transporter activity" RELATED [] is_a: GO:0015166 ! polyol transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0042892 ! chloramphenicol transmembrane transport [Term] id: GO:0042897 name: polymyxin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "polymyxin transporter activity" RELATED [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0042893 ! polymyxin transport [Term] id: GO:0042898 name: fosmidomycin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other." [GOC:jl, PMID:12543685] synonym: "fosmidomycin transporter activity" RELATED [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity relationship: part_of GO:0042894 ! fosmidomycin transport [Term] id: GO:0042899 name: arabinan transmembrane transport namespace: biological_process def: "The process in which arabinan is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] synonym: "arabinan transport" RELATED [] is_a: GO:0015774 ! polysaccharide transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0042900 name: arabinose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015146 ! pentose transmembrane transporter activity relationship: part_of GO:0015751 ! arabinose transmembrane transport [Term] id: GO:0042901 name: arabinan transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0042902 name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein namespace: biological_process def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345] xref: RESID:AA0345 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0042903 name: tubulin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003] xref: Reactome:R-HSA-5618331 "HDAC6 deacetylates microtubules" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity relationship: part_of GO:0090042 ! tubulin deacetylation [Term] id: GO:0042904 name: 9-cis-retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] synonym: "9-cis-retinoic acid anabolism" EXACT [] synonym: "9-cis-retinoic acid biosynthesis" EXACT [] synonym: "9-cis-retinoic acid formation" EXACT [] synonym: "9-cis-retinoic acid synthesis" EXACT [] is_a: GO:0002138 ! retinoic acid biosynthetic process is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process [Term] id: GO:0042905 name: 9-cis-retinoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] synonym: "9-cis-retinoic acid metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042573 ! retinoic acid metabolic process [Term] id: GO:0042906 name: xanthine transport namespace: biological_process def: "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] synonym: "xanthine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport [Term] id: GO:0042907 name: xanthine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity relationship: part_of GO:0042906 ! xanthine transport [Term] id: GO:0042908 name: xenobiotic transport namespace: biological_process def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0042909 name: acridine transport namespace: biological_process def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, Wikipedia:Acridine] is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0042910 name: xenobiotic transmembrane transporter activity namespace: molecular_function alt_id: GO:0015238 alt_id: GO:0015239 alt_id: GO:0015559 alt_id: GO:0015564 alt_id: GO:0090484 def: "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators] subset: goslim_metagenomics synonym: "drug transmembrane transporter activity" RELATED [] synonym: "drug transporter activity" RELATED [] synonym: "multidrug efflux pump activity" RELATED [] synonym: "multidrug transporter activity" RELATED [] synonym: "multidrug, alkane resistant pump activity" RELATED [] synonym: "xenobiotic transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0042908 ! xenobiotic transport [Term] id: GO:0042911 name: acridine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other." [GOC:jl] synonym: "acridine transporter activity" RELATED [] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0042909 ! acridine transport [Term] id: GO:0042912 name: colicin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522] is_a: GO:0022885 ! bacteriocin transmembrane transporter activity [Term] id: GO:0042913 name: group A colicin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417] is_a: GO:0042912 ! colicin transmembrane transporter activity [Term] id: GO:0042914 name: colicin transport namespace: biological_process def: "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522] is_a: GO:0043213 ! bacteriocin transport [Term] id: GO:0042915 name: group A colicin transport namespace: biological_process def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417] is_a: GO:0042914 ! colicin transport [Term] id: GO:0042916 name: alkylphosphonate transport namespace: biological_process def: "The directed movement of an alkylphosphonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015716 ! organic phosphonate transport [Term] id: GO:0042917 name: alkylphosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0015604 ! organic phosphonate transmembrane transporter activity relationship: part_of GO:0042916 ! alkylphosphonate transport [Term] id: GO:0042918 name: alkanesulfonate transport namespace: biological_process def: "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [GOC:jl] synonym: "alkanesulphonate transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0042919 name: benzoate transport namespace: biological_process def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042920 name: 3-hydroxyphenylpropionic acid transmembrane transport namespace: biological_process def: "The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT [] synonym: "3-hydroxyphenylpropionic acid transport" BROAD [] synonym: "m-hydroxyphenylpropionic acid transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0042921 name: glucocorticoid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah] synonym: "glucocorticoid receptor signalling pathway" EXACT [] is_a: GO:0031958 ! corticosteroid receptor signaling pathway [Term] id: GO:0042922 name: neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0042923 name: neuropeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html] is_a: GO:0042277 ! peptide binding [Term] id: GO:0042924 name: neuromedin U binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108] synonym: "NMU binding" EXACT [] is_a: GO:0042923 ! neuropeptide binding [Term] id: GO:0042925 name: benzoate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other." [GOC:jl, ISBN:0721662544] synonym: "benzoate transporter activity" RELATED [] xref: RHEA:32811 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0042919 ! benzoate transport [Term] id: GO:0042926 name: 3-hydroxyphenylpropionic acid transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other." [GOC:jl] synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT [] synonym: "3-hydroxyphenylpropionic acid transporter activity" RELATED [] synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:0042920 ! 3-hydroxyphenylpropionic acid transmembrane transport [Term] id: GO:0042928 name: ferrichrome import into cell namespace: biological_process def: "A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732, PMID:23192658] synonym: "ferrichrome transport" BROAD [] is_a: GO:0015687 ! ferric-hydroxamate import into cell is_a: GO:0015833 ! peptide transport [Term] id: GO:0042929 name: ferrichrome transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732] synonym: "ferrichrome transporter activity" RELATED [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0042928 ! ferrichrome import into cell [Term] id: GO:0042930 name: enterobactin transport namespace: biological_process def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "enterochelin transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042931 name: enterobactin transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other." [GOC:jl] synonym: "enterobactin transporter activity" RELATED [] synonym: "enterochelin transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0042930 ! enterobactin transport [Term] id: GO:0042932 name: chrysobactin transport namespace: biological_process def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport is_a: GO:0042938 ! dipeptide transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042933 name: chrysobactin transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other." [GOC:jl, PMID:8837459] synonym: "chrysobactin transporter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0071916 ! dipeptide transmembrane transporter activity relationship: part_of GO:0042932 ! chrysobactin transport [Term] id: GO:0042934 name: achromobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other." [GOC:jl] synonym: "achromobactin transporter activity" RELATED [] is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0042935 ! achromobactin transport [Term] id: GO:0042935 name: achromobactin transport namespace: biological_process def: "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport is_a: GO:0042886 ! amide transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042937 name: tripeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other." [GOC:jl] synonym: "tripeptide transporter activity" RELATED [] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity relationship: part_of GO:0042939 ! tripeptide transport [Term] id: GO:0042938 name: dipeptide transport namespace: biological_process def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0006857 ! oligopeptide transport [Term] id: GO:0042939 name: tripeptide transport namespace: biological_process def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0006857 ! oligopeptide transport [Term] id: GO:0042940 name: D-amino acid transport namespace: biological_process def: "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0042941 name: D-alanine transport namespace: biological_process def: "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] is_a: GO:0032328 ! alanine transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0042942 name: D-serine transport namespace: biological_process def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] is_a: GO:0015893 ! drug transport is_a: GO:0032329 ! serine transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0042943 name: D-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "D-amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0042940 ! D-amino acid transport [Term] id: GO:0042944 name: D-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "D-alanine transporter activity" BROAD [] is_a: GO:0022858 ! alanine transmembrane transporter activity is_a: GO:0042943 ! D-amino acid transmembrane transporter activity relationship: part_of GO:0042941 ! D-alanine transport [Term] id: GO:0042945 name: D-serine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "D-serine permease activity" EXACT [] synonym: "D-serine transporter activity" BROAD [] is_a: GO:0022889 ! serine transmembrane transporter activity is_a: GO:0042943 ! D-amino acid transmembrane transporter activity relationship: part_of GO:0042942 ! D-serine transport [Term] id: GO:0042946 name: glucoside transport namespace: biological_process def: "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732] is_a: GO:1901656 ! glycoside transport [Term] id: GO:0042947 name: glucoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0042946 ! glucoside transport [Term] id: GO:0042948 name: salicin transport namespace: biological_process def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0015759 ! beta-glucoside transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport [Term] id: GO:0042949 name: arbutin transport namespace: biological_process def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://biotech.icmb.utexas.edu/] is_a: GO:0015759 ! beta-glucoside transport [Term] id: GO:0042950 name: salicin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity relationship: part_of GO:0042948 ! salicin transport [Term] id: GO:0042951 name: arbutin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729] is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity relationship: part_of GO:0042949 ! arbutin transport [Term] id: GO:0042952 name: beta-ketoadipate pathway namespace: biological_process def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091] synonym: "ortho-cleavage pathway" BROAD [] xref: MIPS_funcat:01.05.01.01.09.01 is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0042953 name: lipoprotein transport namespace: biological_process def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] is_a: GO:0015031 ! protein transport is_a: GO:0044872 ! lipoprotein localization [Term] id: GO:0042954 name: obsolete lipoprotein transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732] comment: The reason for obsoletion is this term has been incorrectly used. Details are here: https://github.com/geneontology/go-ontology/issues/17004 xref: Reactome:R-HSA-350168 "LRP2 transports CUBN:GC:25(OH)D from extracellular region to cytosol" is_obsolete: true [Term] id: GO:0042955 name: dextrin transport namespace: biological_process def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0042956 name: maltodextrin transport namespace: biological_process def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0042957 name: dextrin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0042955 ! dextrin transport [Term] id: GO:0042958 name: maltodextrin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0042956 ! maltodextrin transport [Term] id: GO:0042959 name: alkanesulfonate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of alkanesulfonate from one side of a membrane to the other." [GOC:jl] synonym: "alkanesulfonate transporter activity" RELATED [] synonym: "alkanesulphonate transporter activity" EXACT [] is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0042918 ! alkanesulfonate transport [Term] id: GO:0042960 name: antimonite secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl] synonym: "antimonite porter activity" RELATED [] is_a: GO:0015104 ! antimonite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity [Term] id: GO:0042961 name: ATPase-coupled antimonite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:7.3.2.7] synonym: "antimonite ABC transporter" NARROW [] synonym: "antimonite-transporting ATPase activity" EXACT [] synonym: "ATP-dependent antimonite transporter activity" EXACT [] is_a: GO:0015104 ! antimonite transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity [Term] id: GO:0042962 name: acridine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876] synonym: "acridine efflux pump activity" RELATED [] synonym: "acridine:hydrogen antiporter activity" EXACT [] is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0042964 name: thioredoxin reduction namespace: biological_process def: "The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators] synonym: "thioredoxin anabolism" EXACT [] synonym: "thioredoxin biosynthesis" EXACT [] synonym: "thioredoxin formation" EXACT [] synonym: "thioredoxin synthesis" EXACT [] xref: MIPS_funcat:01.20.37.01 is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0042965 name: obsolete glutaredoxin biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators] comment: This term was made obsolete because it refers to the biosynthesis of a protein. synonym: "glutaredoxin anabolism" EXACT [] synonym: "glutaredoxin biosynthesis" EXACT [] synonym: "glutaredoxin formation" EXACT [] synonym: "glutaredoxin synthesis" EXACT [] xref: MIPS_funcat:01.20.37.01 is_obsolete: true [Term] id: GO:0042966 name: biotin carboxyl carrier protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363] synonym: "BCCP biosynthesis" EXACT [] synonym: "BCCP biosynthetic process" EXACT [] synonym: "biotin carboxyl carrier protein anabolism" EXACT [] synonym: "biotin carboxyl carrier protein biosynthesis" EXACT [] synonym: "biotin carboxyl carrier protein formation" EXACT [] synonym: "biotin carboxyl carrier protein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0042967 name: obsolete acyl-carrier-protein biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators] comment: The reason for obsoletion is that acyl-carrier-protein is synthesized by the ribosome like any other protein. synonym: "ACP biosynthesis" EXACT [] synonym: "ACP biosynthetic process" EXACT [] synonym: "acyl carrier protein biosynthesis" EXACT [] synonym: "acyl carrier protein biosynthetic process" EXACT [] synonym: "acyl-carrier protein biosynthesis" EXACT [] synonym: "acyl-carrier-protein anabolism" EXACT [] synonym: "acyl-carrier-protein biosynthesis" EXACT [] synonym: "acyl-carrier-protein formation" EXACT [] synonym: "acyl-carrier-protein synthesis" EXACT [] is_obsolete: true [Term] id: GO:0042968 name: homoserine transport namespace: biological_process def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport [Term] id: GO:0042969 name: lactone transport namespace: biological_process def: "The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0042970 name: homoserine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0042968 ! homoserine transport [Term] id: GO:0042971 name: lactone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0042969 ! lactone transport [Term] id: GO:0042972 name: licheninase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds." [EC:3.2.1.73] synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT [] synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73] synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73] synonym: "lichenase activity" EXACT [] synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73] xref: EC:3.2.1.73 xref: MetaCyc:3.2.1.73-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0042973 name: glucan endo-1,3-beta-D-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans." [EC:3.2.1.39] synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39] synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39] synonym: "callase activity" EXACT [EC:3.2.1.39] synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39] synonym: "endo-1,3-beta-glucanase activity" BROAD [] synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39] synonym: "kitalase activity" EXACT [EC:3.2.1.39] synonym: "laminaranase activity" BROAD [] synonym: "laminarinase activity" BROAD [] synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39] xref: EC:3.2.1.39 xref: MetaCyc:3.2.1.39-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0042974 name: retinoic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796] synonym: "RAR binding" EXACT [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0042975 name: peroxisome proliferator activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781] synonym: "PPAR binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0042976 name: activation of Janus kinase activity namespace: biological_process alt_id: GO:0010531 alt_id: GO:0042977 def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803] synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT [] synonym: "activation of JAK1 kinase activity" NARROW [] synonym: "activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "activation of JAK2 kinase activity" NARROW [] synonym: "activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" EXACT [] synonym: "tyrosine phosphorylation of JAK protein" EXACT [] synonym: "tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "tyrosine phosphorylation of JAK2 protein" NARROW [] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT [Term] id: GO:0042978 name: ornithine decarboxylase activator activity namespace: molecular_function def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] synonym: "L-ornithine carboxy-lyase activator activity" NARROW [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity relationship: positively_regulates GO:0004586 ! ornithine decarboxylase activity [Term] id: GO:0042979 name: ornithine decarboxylase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0004586 ! ornithine decarboxylase activity [Term] id: GO:0042980 name: obsolete cystic fibrosis transmembrane conductance regulator binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "CFTR binding" EXACT [] synonym: "cystic fibrosis transmembrane conductance regulator binding" EXACT [] is_obsolete: true replaced_by: GO:0044325 [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006915 ! apoptotic process relationship: regulates GO:0006915 ! apoptotic process [Term] id: GO:0042982 name: amyloid precursor protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] synonym: "amyloid precursor protein metabolism" EXACT [] synonym: "APP metabolic process" EXACT [] synonym: "APP metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0042983 name: amyloid precursor protein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] synonym: "amyloid precursor protein anabolism" EXACT [] synonym: "amyloid precursor protein biosynthesis" EXACT [] synonym: "amyloid precursor protein formation" EXACT [] synonym: "amyloid precursor protein synthesis" EXACT [] synonym: "APP biosynthesis" EXACT [] synonym: "APP biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0042982 ! amyloid precursor protein metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0042984 name: regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] synonym: "regulation of amyloid precursor protein anabolism" EXACT [] synonym: "regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "regulation of amyloid precursor protein formation" EXACT [] synonym: "regulation of amyloid precursor protein synthesis" EXACT [] synonym: "regulation of APP biosynthesis" EXACT [] synonym: "regulation of APP biosynthetic process" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042983 ! amyloid precursor protein biosynthetic process relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042985 name: negative regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW [] synonym: "negative regulation of amyloid precursor protein anabolism" EXACT [] synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "negative regulation of amyloid precursor protein formation" EXACT [] synonym: "negative regulation of amyloid precursor protein synthesis" EXACT [] synonym: "negative regulation of APP biosynthesis" EXACT [] synonym: "negative regulation of APP biosynthetic process" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042986 name: positive regulation of amyloid precursor protein biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] synonym: "activation of amyloid precursor protein biosynthetic process" NARROW [] synonym: "positive regulation of amyloid precursor protein anabolism" EXACT [] synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT [] synonym: "positive regulation of amyloid precursor protein formation" EXACT [] synonym: "positive regulation of amyloid precursor protein synthesis" EXACT [] synonym: "positive regulation of APP biosynthesis" EXACT [] synonym: "positive regulation of APP biosynthetic process" EXACT [] synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW [] synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT [] synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process [Term] id: GO:0042987 name: amyloid precursor protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] synonym: "amyloid precursor protein breakdown" EXACT [] synonym: "amyloid precursor protein catabolism" EXACT [] synonym: "amyloid precursor protein degradation" EXACT [] synonym: "APP catabolic process" EXACT [] synonym: "APP catabolism" EXACT [] is_a: GO:0042982 ! amyloid precursor protein metabolic process [Term] id: GO:0042988 name: X11-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348] synonym: "X11L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042989 name: sequestering of actin monomers namespace: biological_process def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators] synonym: "actin monomer retention" EXACT [] synonym: "actin monomer sequestering" EXACT [] synonym: "actin monomer sequestering activity" RELATED [] synonym: "actin monomer sequestration" EXACT [] synonym: "actin monomer storage" EXACT [] synonym: "retention of actin monomers" EXACT [] synonym: "sequestration of actin monomers" EXACT [] synonym: "storage of actin monomers" EXACT [] is_a: GO:0030837 ! negative regulation of actin filament polymerization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0042990 name: obsolete regulation of transcription factor import into nucleus namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. synonym: "regulation of transcription factor import into cell nucleus" EXACT [] synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of transcription factor-nucleus import" EXACT [] is_obsolete: true [Term] id: GO:0042991 name: obsolete transcription factor import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. synonym: "transcription factor import into cell nucleus" EXACT [] synonym: "transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "transcription factor-nucleus import" EXACT [] is_obsolete: true [Term] id: GO:0042992 name: obsolete negative regulation of transcription factor import into nucleus namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. synonym: "down regulation of transcription factor import into nucleus" EXACT [] synonym: "down-regulation of transcription factor import into nucleus" EXACT [] synonym: "downregulation of transcription factor import into nucleus" EXACT [] synonym: "inhibition of transcription factor import into nucleus" NARROW [] synonym: "negative regulation of transcription factor import into cell nucleus" EXACT [] synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of transcription factor-nucleus import" EXACT [] is_obsolete: true [Term] id: GO:0042993 name: obsolete positive regulation of transcription factor import into nucleus namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. synonym: "activation of transcription factor import into nucleus" NARROW [] synonym: "positive regulation of transcription factor import into cell nucleus" EXACT [] synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of transcription factor-nucleus import" EXACT [] synonym: "stimulation of transcription factor import into nucleus" NARROW [] synonym: "up regulation of transcription factor import into nucleus" EXACT [] synonym: "up-regulation of transcription factor import into nucleus" EXACT [] synonym: "upregulation of transcription factor import into nucleus" EXACT [] is_obsolete: true [Term] id: GO:0042994 name: cytoplasmic sequestering of transcription factor namespace: biological_process def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic retention of transcription factor" EXACT [] synonym: "cytoplasmic sequestration of transcription factor" EXACT [] synonym: "cytoplasmic storage of transcription factor" EXACT [] synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of transcription factor in cytoplasm" EXACT [] synonym: "sequestering of transcription factor in cytoplasm" EXACT [] synonym: "sequestration of transcription factor in cytoplasm" EXACT [] synonym: "storage of transcription factor in cytoplasm" EXACT [] synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity is_a: GO:0051220 ! cytoplasmic sequestering of protein [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0042996 name: regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043001 ! Golgi to plasma membrane protein transport relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042997 name: negative regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042998 name: positive regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0042999 name: regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043000 name: Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT [] is_a: GO:0043001 ! Golgi to plasma membrane protein transport [Term] id: GO:0043001 name: Golgi to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] is_a: GO:0006893 ! Golgi to plasma membrane transport is_a: GO:0015031 ! protein transport is_a: GO:0061951 ! establishment of protein localization to plasma membrane [Term] id: GO:0043002 name: negative regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW [] is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043003 name: positive regulation of Golgi to plasma membrane CFTR protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport [Term] id: GO:0043004 name: cytoplasmic sequestering of CFTR protein namespace: biological_process def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl] synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT [] synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT [] synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport is_a: GO:0051220 ! cytoplasmic sequestering of protein [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir synonym: "nerve fiber" RELATED [GOC:dph] synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao867568886 is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0043006 name: activation of phospholipase A2 activity by calcium-mediated signaling namespace: biological_process def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb] synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah] synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb] synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0032431 ! activation of phospholipase A2 activity [Term] id: GO:0043007 name: maintenance of rDNA namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010] synonym: "rDNA maintenance" EXACT [] synonym: "ribosomal DNA maintenance" EXACT [] is_a: GO:0043570 ! maintenance of DNA repeat elements [Term] id: GO:0043008 name: ATP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0043010 name: camera-type eye development namespace: biological_process alt_id: GO:0001747 alt_id: GO:0031075 def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development [Term] id: GO:0043011 name: myeloid dendritic cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl] xref: MIPS_funcat:43.03.09.07 xref: Wikipedia:Dendritic_cell is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0043012 name: regulation of fusion of sperm to egg plasma membrane namespace: biological_process def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "regulation of sperm-oocyte fusion" NARROW [] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0080154 ! regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization [Term] id: GO:0043013 name: negative regulation of fusion of sperm to egg plasma membrane namespace: biological_process def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT [] synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW [] synonym: "inhibition of sperm-oocyte fusion" NARROW [] synonym: "negative regulation of sperm-oocyte fusion" NARROW [] is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization [Term] id: GO:0043014 name: alpha-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [GOC:jl] synonym: "alpha tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0043015 name: gamma-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl] synonym: "gamma tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0043016 name: regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "regulation of LTA biosynthesis" EXACT [] synonym: "regulation of LTA biosynthetic process" EXACT [] synonym: "regulation of lymphotoxin A anabolism" EXACT [] synonym: "regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "regulation of lymphotoxin A formation" EXACT [] synonym: "regulation of lymphotoxin A synthesis" EXACT [] synonym: "regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "regulation of TNF-B biosynthesis" EXACT [] synonym: "regulation of TNF-B biosynthetic process" EXACT [] synonym: "regulation of TNF-beta biosynthesis" EXACT [] synonym: "regulation of TNF-beta biosynthetic process" EXACT [] synonym: "regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042109 ! lymphotoxin A biosynthetic process relationship: regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043017 name: positive regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "activation of lymphotoxin A biosynthetic process" NARROW [] synonym: "positive regulation of LTA biosynthesis" EXACT [] synonym: "positive regulation of LTA biosynthetic process" EXACT [] synonym: "positive regulation of lymphotoxin A anabolism" EXACT [] synonym: "positive regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "positive regulation of lymphotoxin A formation" EXACT [] synonym: "positive regulation of lymphotoxin A synthesis" EXACT [] synonym: "positive regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "positive regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "positive regulation of TNF-B biosynthesis" EXACT [] synonym: "positive regulation of TNF-B biosynthetic process" EXACT [] synonym: "positive regulation of TNF-beta biosynthesis" EXACT [] synonym: "positive regulation of TNF-beta biosynthetic process" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] synonym: "stimulation of lymphotoxin A biosynthetic process" NARROW [] synonym: "up regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "up-regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "upregulation of lymphotoxin A biosynthetic process" EXACT [] is_a: GO:0032761 ! positive regulation of lymphotoxin A production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process relationship: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043018 name: negative regulation of lymphotoxin A biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] synonym: "down regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "down-regulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "downregulation of lymphotoxin A biosynthetic process" EXACT [] synonym: "inhibition of lymphotoxin A biosynthetic process" NARROW [] synonym: "negative regulation of LTA biosynthesis" EXACT [] synonym: "negative regulation of LTA biosynthetic process" EXACT [] synonym: "negative regulation of lymphotoxin A anabolism" EXACT [] synonym: "negative regulation of lymphotoxin A biosynthesis" EXACT [] synonym: "negative regulation of lymphotoxin A formation" EXACT [] synonym: "negative regulation of lymphotoxin A synthesis" EXACT [] synonym: "negative regulation of lymphotoxin-alpha biosynthesis" EXACT [] synonym: "negative regulation of lymphotoxin-alpha biosynthetic process" EXACT [] synonym: "negative regulation of TNF-B biosynthesis" EXACT [] synonym: "negative regulation of TNF-B biosynthetic process" EXACT [] synonym: "negative regulation of TNF-beta biosynthesis" EXACT [] synonym: "negative regulation of TNF-beta biosynthetic process" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta biosynthesis" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] is_a: GO:0032721 ! negative regulation of lymphotoxin A production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process relationship: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process [Term] id: GO:0043020 name: NADPH oxidase complex namespace: cellular_component def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767] synonym: "flavocytochrome b558" NARROW [] synonym: "respiratory-burst oxidase" RELATED [] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0043021 name: ribonucleoprotein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] subset: goslim_pir synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk] synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk] synonym: "RNP binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0043022 name: ribosome binding namespace: molecular_function alt_id: GO:0030376 def: "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] synonym: "ribosome receptor activity" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0043023 name: ribosomal large subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0043024 name: ribosomal small subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0043025 name: neuronal cell body namespace: cellular_component def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "neuron cell body" EXACT [] synonym: "neuronal cell soma" EXACT [] xref: NIF_Subcellular:sao1044911821 xref: Wikipedia:Soma_(biology) is_a: GO:0044297 ! cell body relationship: part_of GO:0036477 ! somatodendritic compartment [Term] id: GO:0043027 name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process namespace: molecular_function def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] synonym: "caspase inhibitor activity" BROAD [] is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process intersection_of: GO:0004869 ! cysteine-type endopeptidase inhibitor activity intersection_of: part_of GO:0006915 ! apoptotic process relationship: part_of GO:0006915 ! apoptotic process relationship: part_of GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043028 name: cysteine-type endopeptidase regulator activity involved in apoptotic process namespace: molecular_function def: "Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] synonym: "caspase regulator activity" BROAD [] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043029 name: T cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149] comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "T lymphocyte homeostasis" EXACT [] synonym: "T-cell homeostasis" EXACT [] synonym: "T-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0043030 name: regulation of macrophage activation namespace: biological_process def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] synonym: "regulation of macrophage polarization" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042116 ! macrophage activation relationship: regulates GO:0042116 ! macrophage activation [Term] id: GO:0043031 name: negative regulation of macrophage activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] synonym: "down regulation of macrophage activation" EXACT [] synonym: "down-regulation of macrophage activation" EXACT [] synonym: "downregulation of macrophage activation" EXACT [] synonym: "inhibition of macrophage activation" NARROW [] synonym: "negative regulation of macrophage polarization" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042116 ! macrophage activation relationship: negatively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043032 name: positive regulation of macrophage activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] synonym: "activation of macrophage activation" NARROW [] synonym: "positive regulation of macrophage polarization" EXACT [] synonym: "stimulation of macrophage activation" NARROW [] synonym: "up regulation of macrophage activation" EXACT [] synonym: "up-regulation of macrophage activation" EXACT [] synonym: "upregulation of macrophage activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042116 ! macrophage activation relationship: positively_regulates GO:0042116 ! macrophage activation [Term] id: GO:0043033 name: isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591] subset: goslim_pir synonym: "debranching enzyme complex" BROAD [] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0043034 name: costamere namespace: cellular_component def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378] xref: Wikipedia:Costamere is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0043035 name: chromatin insulator sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] is_a: GO:0031490 ! chromatin DNA binding [Term] id: GO:0043036 name: starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "starch granule" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009536 ! plastid [Term] id: GO:0043038 name: amino acid activation namespace: biological_process def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0043039 name: tRNA aminoacylation namespace: biological_process def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah] synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah] synonym: "tRNA charging" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0043038 ! amino acid activation [Term] id: GO:0043040 name: tRNA aminoacylation for nonribosomal peptide biosynthetic process namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl] synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT [] synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT [] is_a: GO:0043039 ! tRNA aminoacylation is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process [Term] id: GO:0043041 name: amino acid activation for nonribosomal peptide biosynthetic process namespace: biological_process def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl] synonym: "nonribosomal amino acid activation" RELATED [] is_a: GO:0043038 ! amino acid activation relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process [Term] id: GO:0043042 name: amino acid adenylylation by nonribosomal peptide synthase namespace: biological_process def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910] synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT [] synonym: "amino acid adenylation by NRPS" EXACT [] is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0043044 name: ATP-dependent chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764] synonym: "ATP-dependent chromatin remodelling" EXACT [] is_a: GO:0006338 ! chromatin remodeling [Term] id: GO:0043045 name: DNA methylation involved in embryo development namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation is_a: GO:1901538 ! changes to DNA methylation involved in embryo development intersection_of: GO:0006306 ! DNA methylation intersection_of: part_of GO:0009790 ! embryo development [Term] id: GO:0043046 name: DNA methylation involved in gamete generation namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111] synonym: "de novo DNA methylation" RELATED [] is_a: GO:0006306 ! DNA methylation is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0006306 ! DNA methylation intersection_of: part_of GO:0007276 ! gamete generation relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0043047 name: single-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] synonym: "telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:0042162 ! telomeric DNA binding is_a: GO:0098847 ! sequence-specific single stranded DNA binding [Term] id: GO:0043048 name: dolichyl monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl] synonym: "dolichyl monophosphate anabolism" EXACT [] synonym: "dolichyl monophosphate biosynthesis" EXACT [] synonym: "dolichyl monophosphate formation" EXACT [] synonym: "dolichyl monophosphate synthesis" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process [Term] id: GO:0043049 name: otic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0030916 ! otic vesicle formation [Term] id: GO:0043050 name: pharyngeal pumping namespace: biological_process def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052] synonym: "pumping behavior" RELATED [] is_a: GO:0042755 ! eating behavior [Term] id: GO:0043051 name: regulation of pharyngeal pumping namespace: biological_process def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052] is_a: GO:1903998 ! regulation of eating behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043050 ! pharyngeal pumping relationship: regulates GO:0043050 ! pharyngeal pumping [Term] id: GO:0043052 name: thermotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] synonym: "taxis in response to temperature stimulus" EXACT [] xref: Wikipedia:Thermotaxis is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042330 ! taxis [Term] id: GO:0043053 name: dauer entry namespace: biological_process def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, GOC:kmv, PMID:10077613] synonym: "nematode entry into dormancy" EXACT [] is_a: GO:0055115 ! entry into diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043054 name: dauer exit namespace: biological_process def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986] synonym: "exit from nematode dormancy" EXACT [] is_a: GO:0071981 ! exit from diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043055 name: maintenance of dauer namespace: biological_process def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740] synonym: "maintenance of dormancy in the nematode" EXACT [] is_a: GO:0071982 ! maintenance of diapause relationship: part_of GO:0040024 ! dauer larval development [Term] id: GO:0043056 name: forward locomotion namespace: biological_process def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators] is_a: GO:0033058 ! directional locomotion [Term] id: GO:0043057 name: backward locomotion namespace: biological_process def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators] is_a: GO:0033058 ! directional locomotion [Term] id: GO:0043058 name: regulation of backward locomotion namespace: biological_process def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators] is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043057 ! backward locomotion relationship: regulates GO:0043057 ! backward locomotion [Term] id: GO:0043059 name: regulation of forward locomotion namespace: biological_process def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators] is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043056 ! forward locomotion relationship: regulates GO:0043056 ! forward locomotion [Term] id: GO:0043060 name: meiotic metaphase I plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] is_a: GO:0051311 ! meiotic metaphase plate congression relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0043061 name: meiotic metaphase II plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666] is_a: GO:0051311 ! meiotic metaphase plate congression relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043063 name: intercellular bridge organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid] synonym: "intercellular bridge organisation" EXACT [] synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0043064 name: obsolete flagellum organization namespace: biological_process def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "flagellum organisation" EXACT [] synonym: "flagellum organization" EXACT [] synonym: "flagellum organization and biogenesis" RELATED [GOC:mah] is_obsolete: true consider: GO:0044781 consider: GO:0044782 [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006915 ! apoptotic process relationship: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process alt_id: GO:0006916 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006915 ! apoptotic process relationship: negatively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0010941 ! regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0012501 ! programmed cell death relationship: regulates GO:0012501 ! programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process alt_id: GO:0043071 def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0012501 ! programmed cell death relationship: positively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process alt_id: GO:0043072 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060548 ! negative regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0012501 ! programmed cell death relationship: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0043073 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] synonym: "germ-cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0043075 name: obsolete sperm cell nucleus (sensu Magnoliophyta) namespace: cellular_component def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl] comment: This term was made obsolete because the definition was incorrect. synonym: "pollen germ cell nucleus" EXACT [] synonym: "pollen germ-cell nucleus" EXACT [] synonym: "sperm cell nucleus (sensu Magnoliophyta)" EXACT [] is_obsolete: true consider: GO:0048555 [Term] id: GO:0043076 name: megasporocyte nucleus namespace: cellular_component def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153] synonym: "megaspore mother cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0043077 name: initiation of acetate catabolic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl] synonym: "initiation of acetate breakdown" EXACT [] synonym: "initiation of acetate catabolism" EXACT [] synonym: "initiation of acetate degradation" EXACT [] is_a: GO:0045754 ! positive regulation of acetate catabolic process [Term] id: GO:0043078 name: polar nucleus namespace: cellular_component def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043079 name: antipodal cell nucleus namespace: cellular_component def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043082 name: megagametophyte egg cell nucleus namespace: cellular_component def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu] is_a: GO:0043076 ! megasporocyte nucleus [Term] id: GO:0043083 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] subset: goslim_synapse xref: NIF_Subcellular:sao243541954 is_a: GO:0005576 ! extracellular region relationship: part_of GO:0045202 ! synapse [Term] id: GO:0043084 name: penile erection namespace: biological_process def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection] xref: Wikipedia:Erection#Penile_erection is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007620 ! copulation [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] xref: MIPS_funcat:18.02.01.01 is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process alt_id: GO:0048553 def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043087 name: regulation of GTPase activity namespace: biological_process alt_id: GO:0032312 alt_id: GO:0032313 alt_id: GO:0032314 alt_id: GO:0032315 alt_id: GO:0032316 alt_id: GO:0032317 alt_id: GO:0032318 alt_id: GO:0032319 alt_id: GO:0043088 def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] synonym: "regulation of ARF GTPase activity" NARROW [] synonym: "regulation of Cdc42 GTPase activity" NARROW [] synonym: "regulation of Rab GTPase activity" NARROW [] synonym: "regulation of Rac GTPase activity" NARROW [] synonym: "regulation of Ral GTPase activity" NARROW [] synonym: "regulation of Ran GTPase activity" NARROW [] synonym: "regulation of Rap GTPase activity" NARROW [] synonym: "regulation of Ras GTPase activity" NARROW [] synonym: "regulation of Rho GTPase activity" NARROW [] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003924 ! GTPase activity relationship: regulates GO:0003924 ! GTPase activity [Term] id: GO:0043090 name: amino acid import namespace: biological_process def: "The directed movement of amino acids into a cell or organelle." [GOC:jl] synonym: "amino acid uptake" EXACT [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0043093 name: FtsZ-dependent cytokinesis namespace: biological_process def: "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells." [GOC:mah, ISBN:0815108893, PMID:12626683] comment: Note that this term is intended for the annotation of prokaryotic gene products. synonym: "cytokinesis by binary fission" RELATED [GOC:dph] synonym: "prokaryote-type cytokinesis" RELATED [GOC:mah] synonym: "prokaryotic fission" RELATED [Wikipedia:Binary_fission] xref: Wikipedia:Binary_fission is_a: GO:0000910 ! cytokinesis is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019954 ! asexual reproduction relationship: part_of GO:0032505 ! reproduction of a single-celled organism [Term] id: GO:0043094 name: cellular metabolic compound salvage namespace: biological_process def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg] subset: goslim_pir is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0043095 name: regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003934 ! GTP cyclohydrolase I activity relationship: regulates GO:0003934 ! GTP cyclohydrolase I activity [Term] id: GO:0043096 name: purine nucleobase salvage namespace: biological_process def: "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl] synonym: "purine base salvage" EXACT [GOC:go_curators] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage [Term] id: GO:0043097 name: pyrimidine nucleoside salvage namespace: biological_process def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0043098 name: purine deoxyribonucleoside salvage namespace: biological_process def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0043099 name: pyrimidine deoxyribonucleoside salvage namespace: biological_process def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0043100 name: pyrimidine nucleobase salvage namespace: biological_process def: "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl] synonym: "pyrimidine base salvage" EXACT [GOC:go_curators] is_a: GO:0008655 ! pyrimidine-containing compound salvage [Term] id: GO:0043101 name: purine-containing compound salvage namespace: biological_process def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [GOC:jl] subset: goslim_pir synonym: "purine salvage" RELATED [] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0043102 name: amino acid salvage namespace: biological_process def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043103 name: hypoxanthine salvage namespace: biological_process def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732] synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW [] synonym: "guanine, xanthine and their nucleoside salvage" NARROW [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046101 ! hypoxanthine biosynthetic process [Term] id: GO:0043104 name: positive regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] synonym: "activation of GTP cyclohydrolase I activity" NARROW [] synonym: "stimulation of GTP cyclohydrolase I activity" NARROW [] synonym: "up regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "upregulation of GTP cyclohydrolase I activity" EXACT [] is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003934 ! GTP cyclohydrolase I activity relationship: positively_regulates GO:0003934 ! GTP cyclohydrolase I activity [Term] id: GO:0043105 name: negative regulation of GTP cyclohydrolase I activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] synonym: "down regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT [] synonym: "downregulation of GTP cyclohydrolase I activity" EXACT [] synonym: "inhibition of GTP cyclohydrolase I activity" NARROW [] is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003934 ! GTP cyclohydrolase I activity relationship: negatively_regulates GO:0003934 ! GTP cyclohydrolase I activity [Term] id: GO:0043107 name: type IV pilus-dependent motility namespace: biological_process def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238] synonym: "social gliding motility" NARROW [] synonym: "TFP-dependent motility" EXACT [] synonym: "TFP-dependent movement" EXACT [] synonym: "twitching motility" NARROW [] synonym: "type 4 pilus-dependent motility" EXACT [] synonym: "type four pilus-dependent motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0043108 name: pilus retraction namespace: biological_process def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators, PMID:17355871] is_a: GO:0043711 ! pilus organization [Term] id: GO:0043110 name: rDNA spacer replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529] synonym: "RFB binding" EXACT [] is_a: GO:0000182 ! rDNA binding is_a: GO:0031634 ! replication fork barrier binding [Term] id: GO:0043111 name: replication fork arrest namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected." [GOC:jl, GOC:pr, PMID:14645529] comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb] synonym: "replication fork blocking" EXACT [] synonym: "replication fork stalling" EXACT [] is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication [Term] id: GO:0043112 name: receptor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl] synonym: "receptor metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043113 name: receptor clustering namespace: biological_process def: "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460] is_a: GO:0051668 ! localization within membrane is_a: GO:0072657 ! protein localization to membrane relationship: occurs_in GO:0005886 ! plasma membrane [Term] id: GO:0043114 name: regulation of vascular permeability namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0043115 name: precorrin-2 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15613] synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT [] synonym: "CysG" RELATED [EC:1.3.1.76] synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT [] synonym: "Met8p" RELATED [EC:1.3.1.76] synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76] synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76] synonym: "SirC" RELATED [EC:1.3.1.76] synonym: "siroheme synthase activity" BROAD [] xref: EC:1.3.1.76 xref: KEGG_REACTION:R03947 xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN xref: RHEA:15613 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043116 name: negative regulation of vascular permeability namespace: biological_process def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "down regulation of vascular permeability" EXACT [] synonym: "down-regulation of vascular permeability" EXACT [] synonym: "downregulation of vascular permeability" EXACT [] synonym: "inhibition of vascular permeability" NARROW [] is_a: GO:0043114 ! regulation of vascular permeability [Term] id: GO:0043117 name: positive regulation of vascular permeability namespace: biological_process def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl] synonym: "activation of vascular permeability" NARROW [] synonym: "stimulation of vascular permeability" NARROW [] synonym: "up regulation of vascular permeability" EXACT [] synonym: "up-regulation of vascular permeability" EXACT [] synonym: "upregulation of vascular permeability" EXACT [] is_a: GO:0043114 ! regulation of vascular permeability [Term] id: GO:0043120 name: tumor necrosis factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0043121 name: neurotrophin binding namespace: molecular_function alt_id: GO:0048404 alt_id: GO:0048405 def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl, http://www.mercksource.com/, PR:000021998] comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. synonym: "neurotrophic factor binding" EXACT [GOC:aruk, GOC:bc] synonym: "neurotrophin 3 binding" NARROW [] synonym: "neurotrophin 4/5 binding" NARROW [] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "neurotrophin-3 binding" NARROW [] synonym: "neurotrophin-4/5 binding" NARROW [] synonym: "NT 4/5 binding" NARROW [] synonym: "NT-3 binding" NARROW [] synonym: "NT-4 binding" NARROW [] synonym: "NT-4/5 binding" NARROW [] synonym: "NT-5 binding" NARROW [] synonym: "NT3 binding" NARROW [] synonym: "NT4 binding" NARROW [] synonym: "NT5 binding" NARROW [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0043122 name: regulation of I-kappaB kinase/NF-kappaB signaling namespace: biological_process def: "Any process that modulates I-kappaB kinase/NF-kappaB signaling." [GOC:jl, PMID:12773372] synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling [Term] id: GO:0043123 name: positive regulation of I-kappaB kinase/NF-kappaB signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl] synonym: "activation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW [] synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling [Term] id: GO:0043124 name: negative regulation of I-kappaB kinase/NF-kappaB signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling." [GOC:jl] synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW [] synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling [Term] id: GO:0043125 name: ErbB-3 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl] synonym: "HER3 receptor binding" EXACT [] synonym: "Neu/ErbB-2 receptor activity" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0043126 name: regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] synonym: "regulation of PI4K activity" EXACT [] is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity relationship: regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity [Term] id: GO:0043127 name: negative regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "negative regulation of PI4K activity" EXACT [] is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity relationship: negatively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity [Term] id: GO:0043128 name: positive regulation of 1-phosphatidylinositol 4-kinase activity namespace: biological_process def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl] synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "positive regulation of PI4K activity" EXACT [] synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW [] synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity relationship: positively_regulates GO:0004430 ! 1-phosphatidylinositol 4-kinase activity [Term] id: GO:0043129 name: surfactant homeostasis namespace: biological_process def: "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757] is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0043130 name: ubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] xref: Reactome:R-HSA-1169404 "Transfer of ISG15 from E1 to E2 (UBCH8)" xref: Reactome:R-HSA-205008 "Polyubiquitinated NRIF binds to p62 (Sequestosome)" xref: Reactome:R-HSA-983152 "Transfer of ubiquitin from E1 to E2" is_a: GO:0032182 ! ubiquitin-like protein binding [Term] id: GO:0043131 name: erythrocyte enucleation namespace: biological_process def: "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hjd] is_a: GO:0090601 ! enucleation relationship: part_of GO:0043354 ! enucleate erythrocyte maturation [Term] id: GO:0043132 name: NAD transport namespace: biological_process def: "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl] synonym: "NAD (oxidized) transport" EXACT [] synonym: "NAD (reduced) transport" EXACT [] synonym: "NADH transport" EXACT [] synonym: "nicotinamide adenine dinucleotide transport" EXACT [] synonym: "oxidized NAD transport" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT [] synonym: "reduced NAD transport" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0043133 name: hindgut contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0022600 ! digestive system process [Term] id: GO:0043134 name: regulation of hindgut contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043133 ! hindgut contraction relationship: regulates GO:0043133 ! hindgut contraction [Term] id: GO:0043135 name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170] synonym: "PRPP pyrophosphatase activity" EXACT [] xref: MetaCyc:RXN-10969 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0043136 name: glycerol-3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl] xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN xref: Reactome:R-HSA-8955794 "PGP:Mg2+ dimer hydrolyses 3PG to glycerol" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043137 name: DNA replication, removal of RNA primer namespace: biological_process def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238] synonym: "Okazaki initiator RNA removal" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0043138 name: 3'-5' DNA helicase activity namespace: molecular_function alt_id: GO:0043140 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "3' to 5' DNA helicase activity" EXACT [] synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] synonym: "ATP-dependent 3'-5' DNA helicase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0043139 name: 5'-3' DNA helicase activity namespace: molecular_function alt_id: GO:0008722 alt_id: GO:0043141 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "5' to 3' DNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' DNA helicase activity" EXACT [] synonym: "DNA helicase IV activity" NARROW [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0034613 ! cellular protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0006412 ! translation relationship: part_of GO:0006412 ! translation [Term] id: GO:0043144 name: snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397] subset: goslim_yeast is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0043145 name: snoRNA 3'-end cleavage namespace: biological_process def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397] synonym: "snoRNA 3' end cleavage" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic [Term] id: GO:0043149 name: stress fiber assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] synonym: "stress fibre biosynthesis" RELATED [] synonym: "stress fibre formation" RELATED [] is_a: GO:0030038 ! contractile actin filament bundle assembly is_a: GO:0031032 ! actomyosin structure organization [Term] id: GO:0043150 name: DNA synthesis involved in double-strand break repair via homologous recombination namespace: biological_process def: "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators] synonym: "DNA synthesis during double-strand break repair via homologous recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0000731 ! DNA synthesis involved in DNA repair intersection_of: GO:0071897 ! DNA biosynthetic process intersection_of: part_of GO:0000724 ! double-strand break repair via homologous recombination relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0043151 name: DNA synthesis involved in double-strand break repair via single-strand annealing namespace: biological_process def: "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators] synonym: "DNA synthesis during double-strand break repair via single-strand annealing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000731 ! DNA synthesis involved in DNA repair intersection_of: GO:0071897 ! DNA biosynthetic process intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0043152 name: induction of bacterial agglutination namespace: biological_process def: "Any process in which infecting bacteria are clumped together by a host organism." [GOC:jl] is_a: GO:0019731 ! antibacterial humoral response [Term] id: GO:0043153 name: entrainment of circadian clock by photoperiod namespace: biological_process def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] synonym: "photoentrainment of circadian clock" EXACT [PMID:10217146] is_a: GO:0009648 ! photoperiodism is_a: GO:0009649 ! entrainment of circadian clock [Term] id: GO:0043154 name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process alt_id: GO:0001719 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] synonym: "down regulation of caspase activity" EXACT [] synonym: "down-regulation of caspase activity" EXACT [] synonym: "downregulation of caspase activity" EXACT [] synonym: "inhibition of caspase activation" NARROW [] synonym: "inhibition of caspase activity" NARROW [] synonym: "negative regulation of caspase activation" EXACT [] synonym: "negative regulation of caspase activity" BROAD [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: negatively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043155 name: negative regulation of photosynthesis, light reaction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] synonym: "down regulation of photosynthesis, light reaction" EXACT [] synonym: "down-regulation of photosynthesis, light reaction" EXACT [] synonym: "downregulation of photosynthesis, light reaction" EXACT [] synonym: "inhibition of photosynthesis, light reaction" NARROW [] is_a: GO:0042548 ! regulation of photosynthesis, light reaction is_a: GO:1905156 ! negative regulation of photosynthesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019684 ! photosynthesis, light reaction relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0043156 name: chromatin remodeling in response to cation stress namespace: biological_process def: "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0071473 ! cellular response to cation stress [Term] id: GO:0043157 name: response to cation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213] is_a: GO:0009651 ! response to salt stress [Term] id: GO:0043158 name: heterocyst differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl] synonym: "heterocyst biosynthesis" EXACT [] synonym: "heterocyst cell differentiation" EXACT [] synonym: "heterocyst formation" EXACT [] xref: MIPS_funcat:43.01.02.03 is_a: GO:0030154 ! cell differentiation [Term] id: GO:0043159 name: acrosomal matrix namespace: cellular_component def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0001669 ! acrosomal vesicle relationship: part_of GO:0005773 ! vacuole [Term] id: GO:0043160 name: acrosomal lumen namespace: cellular_component def: "The volume enclosed within the acrosome membrane." [GOC:go_curators] is_a: GO:0034774 ! secretory granule lumen is_a: GO:0043202 ! lysosomal lumen relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0043161 name: proteasome-mediated ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] synonym: "proteasomal pathway" EXACT [] synonym: "proteasomal processing" RELATED [] synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "proteasome pathway" RELATED [] xref: MIPS_funcat:14.13.01.01 is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0043162 name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: has_part GO:0007039 ! protein catabolic process in the vacuole relationship: has_part GO:0071985 ! multivesicular body sorting pathway [Term] id: GO:0043163 name: cell envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl] subset: goslim_pir synonym: "cell envelope organisation" EXACT [] synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.34 is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0043164 name: Gram-negative-bacterium-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893] synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0043165 name: Gram-negative-bacterium-type cell outer membrane assembly namespace: biological_process def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254] synonym: "cell outer membrane biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.34.01 is_a: GO:0071709 ! membrane assembly relationship: part_of GO:0043163 ! cell envelope organization [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0043168 name: anion binding namespace: molecular_function def: "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl] is_a: GO:0043167 ! ion binding [Term] id: GO:0043169 name: cation binding namespace: molecular_function def: "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] is_a: GO:0043167 ! ion binding [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0043172 name: obsolete ferredoxin biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it refers to biosynthesis of a protein. synonym: "ferredoxin anabolism" EXACT [] synonym: "ferredoxin biosynthesis" EXACT [] synonym: "ferredoxin formation" EXACT [] synonym: "ferredoxin synthesis" EXACT [] is_obsolete: true [Term] id: GO:0043173 name: nucleotide salvage namespace: biological_process def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl] xref: Wikipedia:Nucleotide_salvage is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043174 name: nucleoside salvage namespace: biological_process def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0043175 name: RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH] is_a: GO:0070063 ! RNA polymerase binding [Term] id: GO:0043176 name: amine binding namespace: molecular_function def: "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0043177 name: organic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732] is_a: GO:0036094 ! small molecule binding [Term] id: GO:0043178 name: alcohol binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0036094 ! small molecule binding [Term] id: GO:0043179 name: rhythmic excitation namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433] is_a: GO:0060024 ! rhythmic synaptic transmission [Term] id: GO:0043180 name: rhythmic inhibition namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators] is_a: GO:0060024 ! rhythmic synaptic transmission [Term] id: GO:0043181 name: vacuolar sequestering namespace: biological_process def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl] synonym: "retention in vacuole" EXACT [] synonym: "sequestering in vacuole" EXACT [] synonym: "sequestration in vacuole" EXACT [] synonym: "storage in vacuole" EXACT [] synonym: "vacuolar retention" EXACT [] synonym: "vacuolar sequestration" EXACT [] synonym: "vacuolar storage" EXACT [] is_a: GO:0051651 ! maintenance of location in cell [Term] id: GO:0043182 name: vacuolar sequestering of sodium ion namespace: biological_process def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl] synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT [] synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT [] synonym: "sodium ion (Na+) retention in vacuole" EXACT [] synonym: "sodium ion (Na+) storage in vacuole" EXACT [] synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT [] synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT [] synonym: "vacuolar sodium ion (Na+) retention" EXACT [] synonym: "vacuolar sodium ion (Na+) storage" EXACT [] is_a: GO:0043181 ! vacuolar sequestering relationship: part_of GO:0006883 ! cellular sodium ion homeostasis [Term] id: GO:0043183 name: vascular endothelial growth factor receptor 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1." [GOC:st] synonym: "Flt-1 binding" EXACT [] synonym: "VEGF receptor 1 binding" EXACT [] synonym: "VEGFR 1 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043184 name: vascular endothelial growth factor receptor 2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2." [GOC:st] synonym: "Flk-1 binding" EXACT [] synonym: "KDR binding" BROAD [] synonym: "kinase domain region binding" EXACT [] synonym: "VEGF receptor 2 binding" EXACT [] synonym: "VEGFR 2 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043185 name: vascular endothelial growth factor receptor 3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3." [GOC:st] synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT [] synonym: "VEGF receptor 3 binding" EXACT [] synonym: "VEGFR 3 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding [Term] id: GO:0043186 name: P granule namespace: cellular_component alt_id: GO:0018994 def: "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] synonym: "germline granule" EXACT [] synonym: "nuage" BROAD [] synonym: "polar granule" EXACT [] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule relationship: part_of GO:0060293 ! germ plasm [Term] id: GO:0043187 name: cell septum surface namespace: cellular_component def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators] synonym: "septum surface" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030428 ! cell septum [Term] id: GO:0043188 name: cell septum edging namespace: cellular_component def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0043189 name: H4/H2A histone acetyltransferase complex namespace: cellular_component def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb] synonym: "H4/H2A HAT complex" EXACT [] is_a: GO:1902562 ! H4 histone acetyltransferase complex [Term] id: GO:0043190 name: ATP-binding cassette (ABC) transporter complex namespace: cellular_component alt_id: GO:0043191 alt_id: GO:0043192 def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] subset: goslim_metagenomics subset: goslim_pir synonym: "ABC-type efflux permease complex" NARROW [] synonym: "ABC-type efflux porter complex" NARROW [] synonym: "ABC-type uptake permease complex" NARROW [] synonym: "mating pheromone exporter" NARROW [] is_a: GO:0098533 ! ATPase dependent transmembrane transport complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0043194 name: axon initial segment namespace: cellular_component def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097] synonym: "initial segment" EXACT [] xref: NIF_Subcellular:sao256000789 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon [Term] id: GO:0043195 name: terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] synonym: "bouton" EXACT [] synonym: "presynaptic bouton" EXACT [] synonym: "synaptic bouton" EXACT [NIF_Subcellular:sao187426937] synonym: "terminal button" EXACT [] xref: NIF_Subcellular:sao187426937 is_a: GO:0098793 ! presynapse relationship: part_of GO:0043679 ! axon terminus [Term] id: GO:0043196 name: varicosity namespace: cellular_component def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon [Term] id: GO:0043197 name: dendritic spine namespace: cellular_component def: "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \"thin\", \"stubby\", \"mushroom\", and \"branched\", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] subset: goslim_synapse synonym: "branched dendritic spine" NARROW [NIF_Subcellular:sao965204139] synonym: "dendrite spine" EXACT [] synonym: "mushroom dendritic spine" NARROW [NIF_Subcellular:sao876577163] synonym: "sessile dendritic spine" NARROW [NIF_Subcellular:sao1536532595] synonym: "stubby dendritic spine" NARROW [NIF_Subcellular:sao317384566] synonym: "thin dendritic spine" NARROW [NIF_Subcellular:sao1232858786] xref: NIF_Subcellular:sao1799103720 xref: Wikipedia:Dendritic_spine is_a: GO:0044309 ! neuron spine is_a: GO:0098794 ! postsynapse relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0043198 name: dendritic shaft namespace: cellular_component def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln] synonym: "trunk" RELATED [NIF_Subcellular:sao1078172392] xref: NIF_Subcellular:sao2034472720 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0043199 name: sulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg] xref: MIPS_funcat:16.12 is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043200 name: response to amino acid namespace: biological_process alt_id: GO:0010237 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg] synonym: "response to amino acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0043201 name: response to leucine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg] is_a: GO:0043200 ! response to amino acid [Term] id: GO:0043202 name: lysosomal lumen namespace: cellular_component def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0043203 name: axon hillock namespace: cellular_component def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln] xref: NIF_Subcellular:sao627227260 xref: Wikipedia:Axon_hillock is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0043204 name: perikaryon namespace: cellular_component def: "The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl] synonym: "cell soma cytoplasm" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043208 name: glycosphingolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] is_a: GO:0046625 ! sphingolipid binding is_a: GO:0051861 ! glycolipid binding [Term] id: GO:0043209 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin] synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204] synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730] synonym: "Schwann cell myelin sheath" NARROW [] xref: FMA:62983 xref: NIF_Subcellular:sao593830697 xref: Wikipedia:Myelin is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043210 name: alkanesulfonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg] is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043211 name: ATPase-coupled carbohydrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane." [GOC:mlg] synonym: "ATP-dependent carbohydrate transmembrane transporter activity" EXACT [] synonym: "carbohydrate ABC transporter" NARROW [] synonym: "carbohydrate-transporting ATPase activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0043212 name: carbohydrate-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)." [GOC:mlg] is_a: GO:0043211 ! ATPase-coupled carbohydrate transmembrane transporter activity [Term] id: GO:0043213 name: bacteriocin transport namespace: biological_process def: "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg] is_a: GO:0015833 ! peptide transport [Term] id: GO:0043214 name: ATPase-coupled bacteriocin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate." [GOC:mlg] synonym: "bacteriocin ABC transporter" NARROW [] is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity is_a: GO:0022885 ! bacteriocin transmembrane transporter activity [Term] id: GO:0043215 name: daunorubicin transport namespace: biological_process def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015893 ! drug transport is_a: GO:1901656 ! glycoside transport [Term] id: GO:0043216 name: ATPase-coupled daunorubicin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg] synonym: "ATP-dependent daunorubicin transmembrane transporter activity" EXACT [] synonym: "daunorubicin ABC transporter" NARROW [] synonym: "daunorubicin-transporting ATPase activity" EXACT [] xref: RHEA:33147 is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0043215 ! daunorubicin transport [Term] id: GO:0043217 name: myelin maintenance namespace: biological_process def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042552 ! myelination [Term] id: GO:0043218 name: compact myelin namespace: cellular_component def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao1123256993] synonym: "oligodendrocyte compact myelin" NARROW [NIF_Subcellular:sao1186642361] synonym: "Schwann cell compact myelin" NARROW [] xref: NIF_Subcellular:sao1123256993 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0043219 name: lateral loop namespace: cellular_component def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh] synonym: "oligodendrocyte paranodal termination" RELATED [NIF_Subcellular:sao1354781919] synonym: "paranodal loop" RELATED [NIF_Subcellular:sao1354781919] synonym: "Schwann cell paranodal termination" RELATED [NIF_Subcellular:sao1067215520] xref: NIF_Subcellular:sao1067215520 xref: NIF_Subcellular:sao1354781919 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043209 ! myelin sheath [Term] id: GO:0043220 name: Schmidt-Lanterman incisure namespace: cellular_component alt_id: GO:0044287 def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh] synonym: "Schmidt-Lanterman cleft" EXACT [] xref: NIF_Subcellular:sao254777664 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043218 ! compact myelin [Term] id: GO:0043221 name: SMC family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531] synonym: "structural maintenance of chromosomes family protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043223 name: cytoplasmic SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "cytoplasmic cullin complex" EXACT [] synonym: "cytoplasmic SCF complex" EXACT [] synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT [] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0019005 ! SCF ubiquitin ligase complex intersection_of: GO:0019005 ! SCF ubiquitin ligase complex intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0043224 name: nuclear SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "nuclear cullin complex" EXACT [] synonym: "nuclear SCF complex" EXACT [] synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT [] is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0019005 ! SCF ubiquitin ligase complex intersection_of: GO:0019005 ! SCF ubiquitin ligase complex intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0043225 name: ATPase-coupled inorganic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)." [GOC:mlg] synonym: "anion ABC transporter" NARROW [] synonym: "anion transmembrane-transporting ATPase activity" RELATED [] synonym: "anion-transporting ATPase activity" EXACT [] synonym: "ATP-dependent anion transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled anion transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-1454916 "The ABCC family mediates organic anion transport" xref: Reactome:R-HSA-5690340 "Defective ABCC6 does not transport organic anion from cytosol to extracellular region" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005622 ! intracellular relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: part_of GO:0005576 ! extracellular region relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_mouse subset: goslim_pir synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0005622 ! intracellular [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0043235 name: receptor complex namespace: cellular_component def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0043236 name: laminin binding namespace: molecular_function alt_id: GO:0043238 alt_id: GO:0043239 def: "Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd] synonym: "laminin-2 binding" NARROW [] synonym: "laminin-4 binding" NARROW [] is_a: GO:0005515 ! protein binding is_a: GO:0050840 ! extracellular matrix binding [Term] id: GO:0043237 name: laminin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators] synonym: "laminin-111 binding" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043236 ! laminin binding [Term] id: GO:0043240 name: Fanconi anaemia nuclear complex namespace: cellular_component def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742] synonym: "FA complex" EXACT [] synonym: "FA core complex" EXACT [] synonym: "FA nuclear complex" EXACT [] synonym: "Fanconi anaemia complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm [Term] id: GO:0043242 name: negative regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] synonym: "negative regulation of protein complex disassembly" RELATED [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032984 ! protein-containing complex disassembly relationship: negatively_regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043243 name: positive regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "positive regulation of protein complex disassembly" RELATED [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032984 ! protein-containing complex disassembly relationship: positively_regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043244 name: regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "regulation of protein complex disassembly" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032984 ! protein-containing complex disassembly relationship: regulates GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043245 name: extraorganismal space namespace: cellular_component def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0043246 name: megasome namespace: cellular_component def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020] is_a: GO:0005764 ! lysosome [Term] id: GO:0043247 name: telomere maintenance in response to DNA damage namespace: biological_process def: "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784] synonym: "DNA damage response, telomere maintenance" EXACT [] is_a: GO:0000723 ! telomere maintenance is_a: GO:0006974 ! cellular response to DNA damage stimulus [Term] id: GO:0043248 name: proteasome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471] synonym: "26S proteasome assembly" NARROW [] synonym: "proteasome complex assembly" EXACT [] synonym: "proteasome maturation" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0043249 name: erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] synonym: "RBC maturation" EXACT [CL:0000232] synonym: "red blood cell maturation" EXACT [CL:0000232] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048821 ! erythrocyte development [Term] id: GO:0043250 name: sodium-dependent organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators] is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0043251 name: sodium-dependent organic anion transport namespace: biological_process def: "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0043252 name: sodium-independent organic anion transport namespace: biological_process def: "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0043253 name: chloroplast ribosome namespace: cellular_component def: "A ribosome contained within a chloroplast." [GOC:ecd] is_a: GO:0009547 ! plastid ribosome intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0065003 ! protein-containing complex assembly relationship: regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0043255 name: regulation of carbohydrate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] synonym: "regulation of carbohydrate anabolism" EXACT [] synonym: "regulation of carbohydrate biosynthesis" EXACT [] synonym: "regulation of carbohydrate formation" EXACT [] synonym: "regulation of carbohydrate synthesis" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016051 ! carbohydrate biosynthetic process relationship: regulates GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0043256 name: laminin complex namespace: cellular_component def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0043257 name: laminin-8 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-411 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043258 name: laminin-9 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-421 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043259 name: laminin-10 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-511 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043260 name: laminin-11 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-521 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043261 name: laminin-12 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-213 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0043262 name: adenosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606] synonym: "adenosine diphosphatase activity" EXACT [] synonym: "ADPase" BROAD [EC:3.6.1.5] synonym: "ADPase activity" EXACT [EC:3.6.1.5] synonym: "ATP diphosphohydrolase activity" EXACT [EC:3.6.1.5] synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.5] xref: MetaCyc:APYRASE-RXN is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0043263 name: cellulosome namespace: cellular_component alt_id: GO:1990296 def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609, PMID:15197390, PMID:20373916] synonym: "scaffoldin complex" NARROW [] xref: Wikipedia:Cellulosome is_a: GO:0043264 ! extracellular non-membrane-bounded organelle [Term] id: GO:0043264 name: extracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] synonym: "extracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle [Term] id: GO:0043265 name: ectoplasm namespace: cellular_component def: "Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0043266 name: regulation of potassium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of K+ transport" EXACT [] synonym: "regulation of potassium conductance" NARROW [] synonym: "regulation of potassium ion conductance" NARROW [] synonym: "regulation of potassium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006813 ! potassium ion transport relationship: regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043267 name: negative regulation of potassium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of potassium ion transport" EXACT [] synonym: "down-regulation of potassium ion transport" EXACT [] synonym: "downregulation of potassium ion transport" EXACT [] synonym: "inhibition of potassium ion transport" NARROW [] synonym: "negative regulation of K+ transport" EXACT [] synonym: "negative regulation of potassium ion conductance" NARROW [] synonym: "negative regulation of potassium transport" EXACT [] synonym: "regulation of K+ conductance" NARROW [] synonym: "regulation of potassium conductance" NARROW [] synonym: "transmembrane conductance regulator activity" RELATED [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006813 ! potassium ion transport relationship: negatively_regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043268 name: positive regulation of potassium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of potassium ion transport" NARROW [] synonym: "positive regulation of K+ conductance" NARROW [] synonym: "positive regulation of K+ transport" EXACT [] synonym: "positive regulation of potassium conductance" NARROW [] synonym: "positive regulation of potassium ion conductance" NARROW [] synonym: "positive regulation of potassium transport" EXACT [] synonym: "stimulation of potassium ion transport" NARROW [] synonym: "up regulation of potassium ion transport" EXACT [] synonym: "up-regulation of potassium ion transport" EXACT [] synonym: "upregulation of potassium ion transport" EXACT [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006813 ! potassium ion transport relationship: positively_regulates GO:0006813 ! potassium ion transport [Term] id: GO:0043269 name: regulation of ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006811 ! ion transport relationship: regulates GO:0006811 ! ion transport [Term] id: GO:0043270 name: positive regulation of ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006811 ! ion transport relationship: positively_regulates GO:0006811 ! ion transport [Term] id: GO:0043271 name: negative regulation of ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006811 ! ion transport relationship: negatively_regulates GO:0006811 ! ion transport [Term] id: GO:0043272 name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl] synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] synonym: "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] is_a: GO:0009693 ! ethylene biosynthetic process intersection_of: GO:0009693 ! ethylene biosynthetic process intersection_of: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0043273 name: CTPase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] synonym: "cytidine triphosphatase activity" EXACT [] is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0043274 name: phospholipase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0043275 name: obsolete glutamate carboxypeptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl] comment: This term was made obsolete because it represents a gene product. synonym: "acetylaspartylglutamate dipeptidase activity" EXACT [] synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21] synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "glutamate carboxypeptidase II activity" EXACT [] synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "mGCP" RELATED [EC:3.4.17.21] synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21] synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21] synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21] synonym: "NAALADase activity" EXACT [EC:3.4.17.21] synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21] synonym: "PSM antigen" RELATED [EC:3.4.17.21] synonym: "PSMA" RELATED [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21] synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] xref: EC:3.4.17.21 is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0043276 name: anoikis namespace: biological_process def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/] synonym: "detachment induced cell death" EXACT [] synonym: "suspension induced apoptosis" EXACT [] xref: Wikipedia:Anoikis is_a: GO:0006915 ! apoptotic process [Term] id: GO:0043277 name: apoptotic cell clearance namespace: biological_process def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. synonym: "apoptotic cell removal" EXACT [] synonym: "efferocytosis" EXACT [PMID:17548650] synonym: "programmed cell clearance" EXACT [] is_a: GO:0006909 ! phagocytosis [Term] id: GO:0043278 name: response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0060359 ! response to ammonium ion is_a: GO:0072347 ! response to anesthetic [Term] id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl] is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0043280 name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] synonym: "activation of caspase activity" NARROW [] synonym: "positive regulation of caspase activity" BROAD [] synonym: "stimulation of caspase activity" NARROW [] synonym: "up regulation of caspase activity" EXACT [] synonym: "up-regulation of caspase activity" EXACT [] synonym: "upregulation of caspase activity" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: positively_regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043281 name: regulation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process alt_id: GO:0043026 def: "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis] synonym: "regulation of caspase activation" NARROW [] synonym: "regulation of caspase activity" BROAD [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process relationship: regulates GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0043282 name: pharyngeal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development relationship: part_of GO:0060465 ! pharynx development [Term] id: GO:0043286 name: regulation of poly(3-hydroxyalkanoate) biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] synonym: "regulation of PHA" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT [] synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process [Term] id: GO:0043287 name: poly(3-hydroxyalkanoate) binding namespace: molecular_function def: "Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] synonym: "PHA binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0043288 name: apocarotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl] synonym: "apo carotenoid metabolic process" EXACT [] synonym: "apocarotenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0043289 name: apocarotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, PMID:27485225] synonym: "apo carotenoid biosynthetic process" EXACT [] synonym: "apocarotenoid anabolism" EXACT [] synonym: "apocarotenoid biosynthesis" EXACT [] synonym: "apocarotenoid formation" EXACT [] synonym: "apocarotenoid synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0043290 name: apocarotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] synonym: "apo carotenoid catabolic process" EXACT [] synonym: "apocarotenoid breakdown" EXACT [] synonym: "apocarotenoid catabolism" EXACT [] synonym: "apocarotenoid degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0043291 name: RAVE complex namespace: cellular_component def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802] synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0043292 name: contractile fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] synonym: "muscle fiber" BROAD [] synonym: "muscle fibre" BROAD [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0043293 name: apoptosome namespace: cellular_component def: "A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137] xref: Wikipedia:Apoptosome is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0043294 name: mitochondrial glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] is_a: GO:0031027 ! glutamate synthase complex (NADH) is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0031027 ! glutamate synthase complex (NADH) intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0043295 name: glutathione binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732] is_a: GO:0043168 ! anion binding is_a: GO:0048037 ! cofactor binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:1900750 ! oligopeptide binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043296 name: apical junction complex namespace: cellular_component def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] synonym: "apical cell junction complex" EXACT [GOC:mah] synonym: "apical junction" EXACT [] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0043297 name: apical junction assembly namespace: biological_process def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] synonym: "apical junction complex assembly" EXACT [GOC:mah] is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0043299 name: leukocyte degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "immune cell degranulation" EXACT [] synonym: "immune cell granule exocytosis" EXACT [] synonym: "leucocyte degranulation" EXACT [] synonym: "leukocyte granule exocytosis" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0043300 name: regulation of leukocyte degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "regulation of immune cell degranulation" EXACT [] synonym: "regulation of immune cell granule exocytosis" EXACT [] synonym: "regulation of leucocyte degranulation" EXACT [] synonym: "regulation of leukocyte granule exocytosis" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043299 ! leukocyte degranulation relationship: regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043301 name: negative regulation of leukocyte degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "down regulation of leukocyte degranulation" EXACT [] synonym: "down-regulation of leukocyte degranulation" EXACT [] synonym: "downregulation of leukocyte degranulation" EXACT [] synonym: "inhibition of leukocyte degranulation" NARROW [] synonym: "negative regulation of immune cell degranulation" EXACT [] synonym: "negative regulation of leucocyte degranulation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:1903306 ! negative regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043299 ! leukocyte degranulation relationship: negatively_regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043302 name: positive regulation of leukocyte degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] synonym: "activation of leukocyte degranulation" NARROW [] synonym: "positive regulation of immune cell degranulation" EXACT [] synonym: "positive regulation of leucocyte degranulation" EXACT [] synonym: "stimulation of leukocyte degranulation" NARROW [] synonym: "up regulation of leukocyte degranulation" EXACT [] synonym: "up-regulation of leukocyte degranulation" EXACT [] synonym: "upregulation of leukocyte degranulation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:1903307 ! positive regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043299 ! leukocyte degranulation relationship: positively_regulates GO:0043299 ! leukocyte degranulation [Term] id: GO:0043303 name: mast cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149] synonym: "mast cell granule exocytosis" EXACT [] is_a: GO:0002279 ! mast cell activation involved in immune response is_a: GO:0032418 ! lysosome localization is_a: GO:0043299 ! leukocyte degranulation is_a: GO:0046907 ! intracellular transport is_a: GO:0051656 ! establishment of organelle localization relationship: occurs_in GO:0042629 ! mast cell granule relationship: part_of GO:0002448 ! mast cell mediated immunity [Term] id: GO:0043304 name: regulation of mast cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149] synonym: "regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043303 ! mast cell degranulation relationship: regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043305 name: negative regulation of mast cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149] synonym: "down regulation of mast cell degranulation" EXACT [] synonym: "down-regulation of mast cell degranulation" EXACT [] synonym: "downregulation of mast cell degranulation" EXACT [] synonym: "inhibition of mast cell degranulation" NARROW [] synonym: "negative regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043303 ! mast cell degranulation relationship: negatively_regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043306 name: positive regulation of mast cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149] synonym: "activation of mast cell degranulation" NARROW [] synonym: "positive regulation of mast cell granule exocytosis" EXACT [] synonym: "stimulation of mast cell degranulation" NARROW [] synonym: "up regulation of mast cell degranulation" EXACT [] synonym: "up-regulation of mast cell degranulation" EXACT [] synonym: "upregulation of mast cell degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043303 ! mast cell degranulation relationship: positively_regulates GO:0043303 ! mast cell degranulation [Term] id: GO:0043307 name: eosinophil activation namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149] is_a: GO:0036230 ! granulocyte activation [Term] id: GO:0043308 name: eosinophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149] synonym: "eosinophil granule exocytosis" EXACT [] is_a: GO:0002278 ! eosinophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002447 ! eosinophil mediated immunity [Term] id: GO:0043309 name: regulation of eosinophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149] synonym: "regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response is_a: GO:1902566 ! regulation of eosinophil activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043308 ! eosinophil degranulation relationship: regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043310 name: negative regulation of eosinophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149] synonym: "down regulation of eosinophil degranulation" EXACT [] synonym: "down-regulation of eosinophil degranulation" EXACT [] synonym: "downregulation of eosinophil degranulation" EXACT [] synonym: "inhibition of eosinophil degranulation" NARROW [] synonym: "negative regulation of eosinophil granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1902567 ! negative regulation of eosinophil activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043308 ! eosinophil degranulation relationship: negatively_regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043311 name: positive regulation of eosinophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149] synonym: "activation of eosinophil degranulation" NARROW [] synonym: "positive regulation of eosinophil granule exocytosis" EXACT [] synonym: "stimulation of eosinophil degranulation" NARROW [] synonym: "up regulation of eosinophil degranulation" EXACT [] synonym: "up-regulation of eosinophil degranulation" EXACT [] synonym: "upregulation of eosinophil degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043309 ! regulation of eosinophil degranulation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1902568 ! positive regulation of eosinophil activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043308 ! eosinophil degranulation relationship: positively_regulates GO:0043308 ! eosinophil degranulation [Term] id: GO:0043312 name: neutrophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149] synonym: "heterophil degranulation" RELATED [] synonym: "neutrophil granule exocytosis" EXACT [] is_a: GO:0002283 ! neutrophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002446 ! neutrophil mediated immunity [Term] id: GO:0043313 name: regulation of neutrophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149] synonym: "regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response is_a: GO:1902563 ! regulation of neutrophil activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043312 ! neutrophil degranulation relationship: regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043314 name: negative regulation of neutrophil degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149] synonym: "down regulation of neutrophil degranulation" EXACT [] synonym: "down-regulation of neutrophil degranulation" EXACT [] synonym: "downregulation of neutrophil degranulation" EXACT [] synonym: "inhibition of neutrophil degranulation" NARROW [] synonym: "negative regulation of neutrophil granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1902564 ! negative regulation of neutrophil activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043312 ! neutrophil degranulation relationship: negatively_regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043315 name: positive regulation of neutrophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149] synonym: "activation of neutrophil degranulation" NARROW [] synonym: "positive regulation of neutrophil granule exocytosis" EXACT [] synonym: "stimulation of neutrophil degranulation" NARROW [] synonym: "up regulation of neutrophil degranulation" EXACT [] synonym: "up-regulation of neutrophil degranulation" EXACT [] synonym: "upregulation of neutrophil degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043313 ! regulation of neutrophil degranulation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1902565 ! positive regulation of neutrophil activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043312 ! neutrophil degranulation relationship: positively_regulates GO:0043312 ! neutrophil degranulation [Term] id: GO:0043316 name: cytotoxic T cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149] synonym: "cytotoxic T cell granule exocytosis" EXACT [] synonym: "cytotoxic T lymphocyte degranulation" EXACT [] synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "cytotoxic T-cell degranulation" EXACT [] synonym: "cytotoxic T-cell granule exocytosis" EXACT [] synonym: "cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0043317 name: regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043316 ! cytotoxic T cell degranulation relationship: regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043318 name: negative regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "down regulation of cytotoxic T cell degranulation" EXACT [] synonym: "down-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "downregulation of cytotoxic T cell degranulation" EXACT [] synonym: "inhibition of cytotoxic T cell degranulation" NARROW [] synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043319 name: positive regulation of cytotoxic T cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149] synonym: "activation of cytotoxic T cell degranulation" NARROW [] synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] synonym: "stimulation of cytotoxic T cell degranulation" NARROW [] synonym: "up regulation of cytotoxic T cell degranulation" EXACT [] synonym: "up-regulation of cytotoxic T cell degranulation" EXACT [] synonym: "upregulation of cytotoxic T cell degranulation" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043316 ! cytotoxic T cell degranulation relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation [Term] id: GO:0043320 name: natural killer cell degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149] synonym: "natural killer cell granule exocytosis" EXACT [] synonym: "NK cell degranulation" EXACT [] synonym: "NK cell granule exocytosis" EXACT [] is_a: GO:0002323 ! natural killer cell activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0043321 name: regulation of natural killer cell degranulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149] synonym: "regulation of natural killer cell granule exocytosis" EXACT [] synonym: "regulation of NK cell degranulation" EXACT [] synonym: "regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043320 ! natural killer cell degranulation relationship: regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043322 name: negative regulation of natural killer cell degranulation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149] synonym: "down regulation of natural killer cell degranulation" EXACT [] synonym: "down-regulation of natural killer cell degranulation" EXACT [] synonym: "downregulation of natural killer cell degranulation" EXACT [] synonym: "inhibition of natural killer cell degranulation" NARROW [] synonym: "negative regulation of natural killer cell granule exocytosis" EXACT [] synonym: "negative regulation of NK cell degranulation" EXACT [] synonym: "negative regulation of NK cell granule exocytosis" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043320 ! natural killer cell degranulation relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043323 name: positive regulation of natural killer cell degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149] synonym: "activation of natural killer cell degranulation" NARROW [] synonym: "positive regulation of natural killer cell granule exocytosis" EXACT [] synonym: "positive regulation of NK cell degranulation" EXACT [] synonym: "positive regulation of NK cell granule exocytosis" EXACT [] synonym: "stimulation of natural killer cell degranulation" NARROW [] synonym: "up regulation of natural killer cell degranulation" EXACT [] synonym: "up-regulation of natural killer cell degranulation" EXACT [] synonym: "upregulation of natural killer cell degranulation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043321 ! regulation of natural killer cell degranulation is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043320 ! natural killer cell degranulation relationship: positively_regulates GO:0043320 ! natural killer cell degranulation [Term] id: GO:0043324 name: pigment metabolic process involved in developmental pigmentation namespace: biological_process def: "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732] synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043474 ! pigment metabolic process involved in pigmentation intersection_of: GO:0042440 ! pigment metabolic process intersection_of: part_of GO:0048066 ! developmental pigmentation relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0043325 name: phosphatidylinositol-3,4-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators] is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding [Term] id: GO:0043326 name: chemotaxis to folate namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators] is_a: GO:0006935 ! chemotaxis is_a: GO:0051593 ! response to folic acid [Term] id: GO:0043327 name: chemotaxis to cAMP namespace: biological_process def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators] synonym: "chemotaxis to 3',5' cAMP" EXACT [] synonym: "chemotaxis to 3',5'-cAMP" EXACT [] synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [] synonym: "chemotaxis to cyclic AMP" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0043328 name: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343] synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway is_a: GO:0072666 ! establishment of protein localization to vacuole intersection_of: GO:0072666 ! establishment of protein localization to vacuole intersection_of: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [Term] id: GO:0043329 name: obsolete protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "OBSOLETE. The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl] comment: The reason for obsoleting is that the term is not cleary defined, ie the membrane to which proteins are being targeted is not specified. synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] is_obsolete: true [Term] id: GO:0043330 name: response to exogenous dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators] comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. synonym: "response to exogenous double-stranded RNA" EXACT [] synonym: "response to viral dsRNA" NARROW [] is_a: GO:0043331 ! response to dsRNA [Term] id: GO:0043331 name: response to dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl] synonym: "response to double-stranded RNA" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0043332 name: mating projection tip namespace: cellular_component def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] synonym: "conjugation tube tip" NARROW [] synonym: "shmoo tip" NARROW [] is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip intersection_of: GO:0030427 ! site of polarized growth intersection_of: part_of GO:0005937 ! mating projection relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0043333 name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity namespace: molecular_function alt_id: GO:0102005 def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" EXACT [] xref: EC:2.1.1.201 xref: MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043334 name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043335 name: protein unfolding namespace: biological_process def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg] is_a: GO:0009987 ! cellular process [Term] id: GO:0043336 name: site-specific telomere resolvase activity namespace: molecular_function def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598] comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. synonym: "ResT" NARROW [] synonym: "TelN" NARROW [] is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0000723 ! telomere maintenance [Term] id: GO:0043337 name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl] synonym: "cardiolipin synthase" BROAD [] synonym: "cardiolipin synthetase" BROAD [] xref: MetaCyc:RXN-8141 xref: Reactome:R-HSA-1483063 "PG and CDP-DAG are converted to CL by CRLS1" is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0043338 name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD [] xref: EC:2.7.7 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0043353 name: enucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "enucleate RBC differentiation" EXACT [CL:0000232] synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation [Term] id: GO:0043354 name: enucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] synonym: "enucleate RBC maturation" EXACT [CL:0000232] synonym: "enucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation relationship: part_of GO:0048822 ! enucleate erythrocyte development [Term] id: GO:0043362 name: nucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] synonym: "nucleate RBC maturation" EXACT [CL:0000232] synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation relationship: part_of GO:0048823 ! nucleate erythrocyte development [Term] id: GO:0043363 name: nucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] synonym: "nucleate RBC differentiation" EXACT [CL:0000232] synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation [Term] id: GO:0043364 name: glycyl-radical enzyme activating activity namespace: molecular_function def: "Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [GOC:jl, PMID:24486374] comment: Changed term label and definition as requested https://github.com/geneontology/go-ontology/issues/14190 subset: goslim_pir synonym: "catalysis of free radical formation" BROAD [] xref: EC:1.97.1 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043365 name: [formate-C-acetyltransferase]-activating enzyme activity namespace: molecular_function alt_id: GO:0008862 def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109] comment: Changed parent as requested https://github.com/geneontology/go-ontology/issues/14190 synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4] synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4] synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4] synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4] synonym: "PFL activase activity" EXACT [EC:1.97.1.4] synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4] synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] xref: EC:1.97.1.4 xref: MetaCyc:TDCEACT-RXN is_a: GO:0043364 ! glycyl-radical enzyme activating activity [Term] id: GO:0043366 name: beta selection namespace: biological_process def: "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149, PMID:12220932] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043367 name: CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043368 name: positive T cell selection namespace: biological_process def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722] synonym: "positive T lymphocyte selection" EXACT [] synonym: "positive T-cell selection" EXACT [] synonym: "positive T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] id: GO:0043369 name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149] synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0043368 ! positive T cell selection [Term] id: GO:0043370 name: regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation relationship: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043371 name: negative regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043372 name: positive regulation of CD4-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation relationship: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043373 name: CD4-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149] synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002363 ! alpha-beta T cell lineage commitment is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0043374 name: CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0043375 name: CD8-positive, alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149] synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT [] synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002363 ! alpha-beta T cell lineage commitment is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043376 name: regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043377 name: negative regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043378 name: positive regulation of CD8-positive, alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0043379 name: memory T cell differentiation namespace: biological_process def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory T cell development" RELATED [GOC:add] synonym: "memory T lymphocyte differentiation" EXACT [] synonym: "memory T-cell differentiation" EXACT [] synonym: "memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0090715 ! immunological memory formation process [Term] id: GO:0043380 name: regulation of memory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of memory T cell development" RELATED [GOC:add] synonym: "regulation of memory T lymphocyte differentiation" EXACT [] synonym: "regulation of memory T-cell differentiation" EXACT [] synonym: "regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043379 ! memory T cell differentiation relationship: regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043381 name: negative regulation of memory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of memory T cell differentiation" EXACT [] synonym: "down-regulation of memory T cell differentiation" EXACT [] synonym: "downregulation of memory T cell differentiation" EXACT [] synonym: "inhibition of memory T cell differentiation" NARROW [] synonym: "negative regulation of memory T cell development" RELATED [GOC:add] synonym: "negative regulation of memory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of memory T-cell differentiation" EXACT [] synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043379 ! memory T cell differentiation relationship: negatively_regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043382 name: positive regulation of memory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of memory T cell differentiation" NARROW [] synonym: "positive regulation of memory T cell development" RELATED [GOC:add] synonym: "positive regulation of memory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of memory T-cell differentiation" EXACT [] synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of memory T cell differentiation" NARROW [] synonym: "up regulation of memory T cell differentiation" EXACT [] synonym: "up-regulation of memory T cell differentiation" EXACT [] synonym: "upregulation of memory T cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043380 ! regulation of memory T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043379 ! memory T cell differentiation relationship: positively_regulates GO:0043379 ! memory T cell differentiation [Term] id: GO:0043383 name: negative T cell selection namespace: biological_process def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722] synonym: "negative T lymphocyte selection" EXACT [] synonym: "negative T-cell selection" EXACT [] synonym: "negative T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] id: GO:0043384 name: pre-T cell receptor complex namespace: cellular_component def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932] synonym: "pre-T lymphocyte receptor complex" EXACT [] synonym: "pre-T-cell receptor complex" EXACT [] synonym: "pre-T-lymphocyte receptor complex" EXACT [] synonym: "pre-TCR complex" EXACT [] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0043385 name: mycotoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0043386 name: mycotoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin anabolism" EXACT [] synonym: "mycotoxin biosynthesis" EXACT [] synonym: "mycotoxin formation" EXACT [] synonym: "mycotoxin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043387 name: mycotoxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin breakdown" EXACT [] synonym: "mycotoxin catabolism" EXACT [] synonym: "mycotoxin degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043388 name: positive regulation of DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] synonym: "activation of DNA binding" NARROW [] synonym: "stimulation of DNA binding" NARROW [] synonym: "up regulation of DNA binding" EXACT [] synonym: "up-regulation of DNA binding" EXACT [] synonym: "upregulation of DNA binding" EXACT [] is_a: GO:0051099 ! positive regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003677 ! DNA binding relationship: positively_regulates GO:0003677 ! DNA binding [Term] id: GO:0043392 name: negative regulation of DNA binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] synonym: "down regulation of DNA binding" EXACT [] synonym: "down-regulation of DNA binding" EXACT [] synonym: "downregulation of DNA binding" EXACT [] synonym: "inhibition of DNA binding" NARROW [] is_a: GO:0051100 ! negative regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003677 ! DNA binding relationship: negatively_regulates GO:0003677 ! DNA binding [Term] id: GO:0043393 name: regulation of protein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005515 ! protein binding relationship: regulates GO:0005515 ! protein binding [Term] id: GO:0043394 name: proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732] is_a: GO:0005515 ! protein binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0043395 name: heparan sulfate proteoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732] synonym: "heparin proteoglycan binding" RELATED [] is_a: GO:0043168 ! anion binding is_a: GO:0043394 ! proteoglycan binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043396 name: corticotropin-releasing hormone secretion namespace: biological_process def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914] synonym: "corticotropin-releasing factor secretion" EXACT [] synonym: "CRF secretion" EXACT [] synonym: "CRH secretion" EXACT [] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0043397 name: regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914] synonym: "regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "regulation of CRF secretion" EXACT [] synonym: "regulation of CRH secretion" EXACT [] is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043396 ! corticotropin-releasing hormone secretion relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0043398 name: HLH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0043399 name: tRNA A64-2'-O-ribosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819] synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0043400 name: cortisol secretion namespace: biological_process def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914] synonym: "hydrocortisone secretion" EXACT [CHEBI:17650] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport is_a: GO:0035933 ! glucocorticoid secretion [Term] id: GO:0043401 name: steroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] synonym: "steroid hormone mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus [Term] id: GO:0043402 name: glucocorticoid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347] synonym: "glucocorticoid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway relationship: part_of GO:0071385 ! cellular response to glucocorticoid stimulus [Term] id: GO:0043403 name: skeletal muscle tissue regeneration namespace: biological_process def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119] synonym: "myofiber turnover" RELATED [] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0043404 name: corticotropin-releasing hormone receptor activity namespace: molecular_function alt_id: GO:0031636 def: "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity." [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857] synonym: "adrenocorticotropin-releasing hormone receptor activity" EXACT [] synonym: "corticotropin-releasing factor receptor activity" EXACT [GOC:bf] synonym: "CRF receptor activity" EXACT [GOC:bf] synonym: "CRH receptor activity" EXACT [GOC:bf] is_a: GO:0001653 ! peptide receptor activity relationship: has_part GO:0051424 ! corticotropin-releasing hormone binding relationship: part_of GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0043405 name: regulation of MAP kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "Regulation of MAPK activity" EXACT [GOC:dph] synonym: "regulation of mitogen activated protein kinase activity" EXACT [] synonym: "regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004707 ! MAP kinase activity relationship: regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043406 name: positive regulation of MAP kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "positive regulation of mitogen activated protein kinase activity" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT [] synonym: "stimulation of MAPK activity" NARROW [] synonym: "up regulation of MAPK activity" EXACT [] synonym: "up-regulation of MAPK activity" EXACT [] synonym: "upregulation of MAPK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004707 ! MAP kinase activity relationship: positively_regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043407 name: negative regulation of MAP kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] synonym: "down regulation of MAPK activity" EXACT [] synonym: "down-regulation of MAPK activity" EXACT [] synonym: "downregulation of MAPK activity" EXACT [] synonym: "inhibition of MAPK activity" NARROW [] synonym: "negative regulation of mitogen activated protein kinase activity" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004707 ! MAP kinase activity relationship: negatively_regulates GO:0004707 ! MAP kinase activity [Term] id: GO:0043408 name: regulation of MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000165 ! MAPK cascade relationship: regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043409 name: negative regulation of MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "down regulation of MAPKKK cascade" EXACT [] synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "down-regulation of MAPKKK cascade" EXACT [] synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling] synonym: "downregulation of MAPKKK cascade" EXACT [] synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling] synonym: "inhibition of MAPKKK cascade" NARROW [] synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000165 ! MAPK cascade relationship: negatively_regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043410 name: positive regulation of MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] synonym: "activation of MAPK cascade" NARROW [GOC:signaling] synonym: "activation of MAPKKK cascade" NARROW [] synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling] synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling] synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling] synonym: "stimulation of MAPKKK cascade" NARROW [] synonym: "up regulation of MAPKKK cascade" EXACT [] synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling] synonym: "up-regulation of MAPKKK cascade" EXACT [] synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling] synonym: "upregulation of MAPKKK cascade" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000165 ! MAPK cascade relationship: positively_regulates GO:0000165 ! MAPK cascade [Term] id: GO:0043411 name: obsolete myopalladin binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "myopalladin binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043413 name: macromolecule glycosylation namespace: biological_process def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl] is_a: GO:0043412 ! macromolecule modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0043414 name: macromolecule methylation namespace: biological_process def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] is_a: GO:0032259 ! methylation is_a: GO:0043412 ! macromolecule modification is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0043415 name: positive regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl] synonym: "activation of skeletal muscle regeneration" NARROW [] synonym: "stimulation of skeletal muscle regeneration" NARROW [] synonym: "up regulation of skeletal muscle regeneration" EXACT [] synonym: "up-regulation of skeletal muscle regeneration" EXACT [] synonym: "upregulation of skeletal muscle regeneration" EXACT [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0090303 ! positive regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043416 name: regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061041 ! regulation of wound healing is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043403 ! skeletal muscle tissue regeneration relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043417 name: negative regulation of skeletal muscle tissue regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl] synonym: "down regulation of skeletal muscle regeneration" EXACT [] synonym: "down-regulation of skeletal muscle regeneration" EXACT [] synonym: "downregulation of skeletal muscle regeneration" EXACT [] synonym: "inhibition of skeletal muscle regeneration" NARROW [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061045 ! negative regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0043418 name: homocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl] synonym: "homocysteine breakdown" EXACT [] synonym: "homocysteine catabolism" EXACT [] synonym: "homocysteine degradation" EXACT [] xref: MIPS_funcat:01.01.06.05.01.02 is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0050667 ! homocysteine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0043419 name: urea catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl] synonym: "urea breakdown" EXACT [] synonym: "urea catabolism" EXACT [] synonym: "urea decomposition" EXACT [] synonym: "urea degradation" EXACT [] xref: MIPS_funcat:01.02.01.09.01 is_a: GO:0019627 ! urea metabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0043420 name: anthranilate metabolic process namespace: biological_process alt_id: GO:0018869 def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [GOC:jl] synonym: "2-aminobenzoate metabolic process" EXACT [] synonym: "2-aminobenzoate metabolism" EXACT [] synonym: "anthranilate metabolism" EXACT [] synonym: "anthranilic acid metabolic process" NARROW [] synonym: "anthranilic acid metabolism" NARROW [] synonym: "ortho-aminobenzoic acid metabolic process" NARROW [] synonym: "ortho-aminobenzoic acid metabolism" NARROW [] xref: UM-BBD_pathwayID:abz2 is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0043421 name: anthranilate catabolic process namespace: biological_process alt_id: GO:0019259 def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [GOC:jl] synonym: "2-aminobenzoate breakdown" EXACT [] synonym: "2-aminobenzoate catabolic process" EXACT [] synonym: "2-aminobenzoate catabolism" NARROW [] synonym: "2-aminobenzoate degradation" EXACT [] synonym: "anthranilate breakdown" EXACT [] synonym: "anthranilate catabolism" EXACT [] synonym: "anthranilate degradation" EXACT [] synonym: "anthranilic acid catabolic process" NARROW [] synonym: "anthranilic acid catabolism" NARROW [] synonym: "ortho-aminobenzoic acid catabolic process" NARROW [] synonym: "ortho-aminobenzoic acid catabolism" NARROW [] xref: MetaCyc:2AMINOBENZDEG-PWY xref: MIPS_funcat:01.02.01.09.06 is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0043420 ! anthranilate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0043422 name: protein kinase B binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/] synonym: "Akt binding" EXACT [] synonym: "PKB binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043423 name: 3-phosphoinositide-dependent protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase." [GOC:jl] synonym: "phosphatidylinositol-3-phosphate-dependent protein kinase binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043424 name: protein histidine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein histidine kinase." [GOC:jl] synonym: "histidine kinase binding" EXACT [] synonym: "histidine-protein kinase binding" EXACT [] synonym: "protein-histidine kinase binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0043425 name: bHLH transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] is_a: GO:0140297 ! DNA-binding transcription factor binding [Term] id: GO:0043426 name: MRF binding namespace: molecular_function alt_id: GO:0051576 alt_id: GO:0051577 alt_id: GO:0051578 alt_id: GO:0051579 def: "Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875] synonym: "Mrf4 binding" NARROW [] synonym: "Myf5 binding" NARROW [] synonym: "MyoD binding" NARROW [] synonym: "myogenin binding" NARROW [] is_a: GO:0043425 ! bHLH transcription factor binding [Term] id: GO:0043427 name: carbon fixation by 3-hydroxypropionate cycle namespace: biological_process def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028] synonym: "3-hydroxypropionate cycle" EXACT [] synonym: "3-hydroxypropionate pathway" EXACT [] synonym: "hydroxypropionate cycle" EXACT [] synonym: "hydroxypropionate pathway" EXACT [] xref: MIPS_funcat:01.05.01.05.05 is_a: GO:0015977 ! carbon fixation [Term] id: GO:0043428 name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: MetaCyc:RXN-9227 is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043429 name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043430 name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: Reactome:R-HSA-2162188 "MDMQ10H2 is methylated to DMQ10H2 by COQ5" is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] id: GO:0043431 name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344] synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT [] synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT [] xref: MetaCyc:2.1.1.64-RXN is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0043433 name: negative regulation of DNA-binding transcription factor activity namespace: biological_process alt_id: GO:1904168 alt_id: GO:2000824 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] synonym: "down regulation of transcription factor activity" EXACT [] synonym: "down-regulation of transcription factor activity" EXACT [] synonym: "downregulation of transcription factor activity" EXACT [] synonym: "inhibition of transcription factor activity" NARROW [] synonym: "negative regulation of androgen receptor activity" NARROW [] synonym: "negative regulation of DNA binding transcription factor activity" EXACT [] synonym: "negative regulation of sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "negative regulation of thyroid hormone receptor activity" NARROW [] synonym: "negative regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003700 ! DNA-binding transcription factor activity relationship: negatively_regulates GO:0003700 ! DNA-binding transcription factor activity creation_date: 2011-07-15T10:56:12Z [Term] id: GO:0043434 name: response to peptide hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone is_a: GO:1901652 ! response to peptide [Term] id: GO:0043435 name: response to corticotropin-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone] synonym: "response to corticoliberin stimulus" EXACT [] synonym: "response to corticotropin-releasing factor stimulus" EXACT [] synonym: "response to corticotropin-releasing hormone stimulus" EXACT [GOC:dos] synonym: "response to CRF stimulus" EXACT [] synonym: "response to CRH stimulus" EXACT [] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0043438 name: acetoacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [Wikipedia:Acetoacetic_acid] synonym: "3-oxobutanoate metabolic process" EXACT [] synonym: "3-oxobutanoate metabolism" EXACT [] synonym: "3-oxobutanoic acid metabolic process" EXACT [] synonym: "3-oxobutanoic acid metabolism" EXACT [] synonym: "acetoacetate metabolic process" EXACT [] synonym: "acetoacetate metabolism" EXACT [] synonym: "acetoacetic acid metabolism" EXACT [] synonym: "beta ketobutyric acid metabolic process" EXACT [] synonym: "beta ketobutyric acid metabolism" EXACT [] synonym: "beta-ketobutyric acid metabolic process" EXACT [] synonym: "beta-ketobutyric acid metabolism" EXACT [] synonym: "diacetic acid metabolic process" EXACT [] synonym: "diacetic acid metabolism" EXACT [] is_a: GO:0046459 ! short-chain fatty acid metabolic process is_a: GO:1902224 ! ketone body metabolic process [Term] id: GO:0043441 name: acetoacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] synonym: "acetoacetic acid anabolism" EXACT [] synonym: "acetoacetic acid biosynthesis" EXACT [] synonym: "acetoacetic acid formation" EXACT [] synonym: "acetoacetic acid synthesis" EXACT [] xref: MIPS_funcat:01.20.05.01 is_a: GO:0043438 ! acetoacetic acid metabolic process is_a: GO:0046951 ! ketone body biosynthetic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0043442 name: acetoacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] synonym: "acetoacetic acid breakdown" EXACT [] synonym: "acetoacetic acid catabolism" EXACT [] synonym: "acetoacetic acid degradation" EXACT [] is_a: GO:0019626 ! short-chain fatty acid catabolic process is_a: GO:0043438 ! acetoacetic acid metabolic process is_a: GO:0046952 ! ketone body catabolic process [Term] id: GO:0043443 name: acetone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl] synonym: "2-propanone metabolic process" EXACT [] synonym: "2-propanone metabolism" EXACT [] synonym: "acetone metabolism" EXACT [] synonym: "dimethyl ketone metabolic process" EXACT [] synonym: "dimethyl ketone metabolism" EXACT [] synonym: "propan-2-one metabolic process" EXACT [] synonym: "propan-2-one metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902224 ! ketone body metabolic process [Term] id: GO:0043444 name: acetone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl] synonym: "2-propanone catabolic process" EXACT [] synonym: "2-propanone catabolism" EXACT [] synonym: "acetone breakdown" EXACT [] synonym: "acetone catabolism" EXACT [] synonym: "acetone degradation" EXACT [] synonym: "dimethyl ketone catabolic process" EXACT [] synonym: "dimethyl ketone catabolism" EXACT [] synonym: "propan-2-one catabolic process" EXACT [] synonym: "propan-2-one catabolism" EXACT [] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0043443 ! acetone metabolic process is_a: GO:0046952 ! ketone body catabolic process [Term] id: GO:0043445 name: acetone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl] synonym: "2-propanone biosynthesis" EXACT [] synonym: "2-propanone biosynthetic process" EXACT [] synonym: "acetone anabolism" EXACT [] synonym: "acetone biosynthesis" EXACT [] synonym: "acetone formation" EXACT [] synonym: "acetone synthesis" EXACT [] synonym: "dimethyl ketone biosynthesis" EXACT [] synonym: "dimethyl ketone biosynthetic process" EXACT [] synonym: "propan-2-one biosynthesis" EXACT [] synonym: "propan-2-one biosynthetic process" EXACT [] xref: MIPS_funcat:01.20.05.01 is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043443 ! acetone metabolic process is_a: GO:0046951 ! ketone body biosynthetic process [Term] id: GO:0043446 name: cellular alkane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [GOC:jl, Wikipedia:Alkane] subset: goslim_pir synonym: "alkane metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043447 name: alkane biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane] synonym: "alkane anabolism" EXACT [] synonym: "alkane biosynthesis" EXACT [] synonym: "alkane formation" EXACT [] synonym: "alkane synthesis" EXACT [] xref: MIPS_funcat:01.20.05.03 is_a: GO:0043446 ! cellular alkane metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0043448 name: alkane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane] synonym: "alkane breakdown" EXACT [] synonym: "alkane catabolism" EXACT [] synonym: "alkane degradation" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0043449 name: cellular alkene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [GOC:jl, Wikipedia:Alkene] subset: goslim_pir synonym: "alkene metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1900673 ! olefin metabolic process [Term] id: GO:0043450 name: alkene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene] synonym: "alkene anabolism" EXACT [] synonym: "alkene biosynthesis" EXACT [] synonym: "alkene formation" EXACT [] synonym: "alkene synthesis" EXACT [] xref: MIPS_funcat:01.20.05.03 is_a: GO:0043449 ! cellular alkene metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process [Term] id: GO:0043451 name: alkene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene] synonym: "alkene breakdown" EXACT [] synonym: "alkene catabolism" EXACT [] synonym: "alkene degradation" EXACT [] is_a: GO:0043449 ! cellular alkene metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0043452 name: cellular alkyne metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [GOC:jl, Wikipedia:Alkyne] subset: goslim_pir synonym: "alkyne metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0043453 name: alkyne biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, Wikipedia:Alkyne] synonym: "alkyne anabolism" EXACT [] synonym: "alkyne biosynthesis" EXACT [] synonym: "alkyne formation" EXACT [] synonym: "alkyne synthesis" EXACT [] xref: MIPS_funcat:01.20.05.07 is_a: GO:0043452 ! cellular alkyne metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0043454 name: alkyne catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, Wikipedia:Alkyne] synonym: "alkyne breakdown" EXACT [] synonym: "alkyne catabolism" EXACT [] synonym: "alkyne degradation" EXACT [] is_a: GO:0043452 ! cellular alkyne metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0043455 name: regulation of secondary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] synonym: "regulation of secondary metabolism" EXACT [] xref: MIPS_funcat:01.20.70 is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019748 ! secondary metabolic process relationship: regulates GO:0019748 ! secondary metabolic process [Term] id: GO:0043456 name: regulation of pentose-phosphate shunt namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl] synonym: "regulation of pentose phosphate pathway" EXACT [] synonym: "regulation of pentose phosphate shunt" EXACT [] synonym: "regulation of pentose-phosphate pathway" EXACT [] xref: MIPS_funcat:02.07.05 is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:1902031 ! regulation of NADP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006098 ! pentose-phosphate shunt relationship: regulates GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0043457 name: regulation of cellular respiration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl] xref: MIPS_funcat:02.13.05 is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045333 ! cellular respiration relationship: regulates GO:0045333 ! cellular respiration [Term] id: GO:0043458 name: ethanol biosynthetic process involved in glucose fermentation to ethanol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP." [GOC:dph, GOC:jl, GOC:tb] synonym: "ethanol anabolism during fermentation" RELATED [] synonym: "ethanol formation during fermentation" RELATED [] synonym: "ethanol synthesis during fermentation" RELATED [] xref: MIPS_funcat:02.16.01 is_a: GO:0006115 ! ethanol biosynthetic process intersection_of: GO:0006115 ! ethanol biosynthetic process intersection_of: part_of GO:0019655 ! glycolytic fermentation to ethanol relationship: part_of GO:0019655 ! glycolytic fermentation to ethanol [Term] id: GO:0043459 name: obsolete response to short exposure to lithium ion namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444] comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time. synonym: "response to short exposure to lithium ion" EXACT [] is_obsolete: true [Term] id: GO:0043460 name: obsolete response to long exposure to lithium ion namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444] comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time. synonym: "response to long exposure to lithium ion" EXACT [] is_obsolete: true [Term] id: GO:0043461 name: proton-transporting ATP synthase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/] synonym: "F-type ATPase complex assembly" EXACT [] is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly [Term] id: GO:0043462 name: regulation of ATPase activity namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl] synonym: "regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016887 ! ATPase activity relationship: regulates GO:0016887 ! ATPase activity [Term] id: GO:0043463 name: regulation of rhamnose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl] synonym: "regulation of rhamnose breakdown" EXACT [] synonym: "regulation of rhamnose catabolism" EXACT [] synonym: "regulation of rhamnose degradation" EXACT [] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019301 ! rhamnose catabolic process relationship: regulates GO:0019301 ! rhamnose catabolic process [Term] id: GO:0043464 name: malolactic fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948] synonym: "L-malate fermentation" BROAD [] synonym: "malate fermentation" BROAD [] synonym: "malo-lactate fermentation" EXACT [] synonym: "malolactate fermentation" EXACT [] xref: MIPS_funcat:02.16.03.07 xref: Wikipedia:Malolactic_fermentation is_a: GO:0006113 ! fermentation [Term] id: GO:0043465 name: regulation of fermentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl] xref: MIPS_funcat:02.16.20 is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006113 ! fermentation relationship: regulates GO:0006113 ! fermentation [Term] id: GO:0043466 name: pyrimidine nucleobase fermentation namespace: biological_process def: "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP." [GOC:jl] synonym: "pyrimidine base fermentation" EXACT [GOC:go_curators] synonym: "pyrimidine fermentation" RELATED [] xref: MIPS_funcat:02.16.17.05 is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0043467 name: regulation of generation of precursor metabolites and energy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] xref: MIPS_funcat:02.45.20 is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006091 ! generation of precursor metabolites and energy relationship: regulates GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0043468 name: regulation of fucose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019317 ! fucose catabolic process relationship: regulates GO:0019317 ! fucose catabolic process [Term] id: GO:0043469 name: regulation of D-xylose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042843 ! D-xylose catabolic process relationship: regulates GO:0042843 ! D-xylose catabolic process [Term] id: GO:0043470 name: regulation of carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016052 ! carbohydrate catabolic process relationship: regulates GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0043471 name: regulation of cellular carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044275 ! cellular carbohydrate catabolic process relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0043472 name: IgD binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of a D isotype." [PMID:12886015] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0043474 name: pigment metabolic process involved in pigmentation namespace: biological_process def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb] synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during pigmentation" RELATED [] is_a: GO:0042440 ! pigment metabolic process intersection_of: GO:0042440 ! pigment metabolic process intersection_of: part_of GO:0043473 ! pigmentation relationship: part_of GO:0043473 ! pigmentation [Term] id: GO:0043475 name: pigment metabolic process involved in pigment accumulation namespace: biological_process def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl] synonym: "pigment metabolic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] synonym: "pigment metabolism during pigment accumulation" RELATED [] is_a: GO:0043474 ! pigment metabolic process involved in pigmentation intersection_of: GO:0042440 ! pigment metabolic process intersection_of: part_of GO:0043476 ! pigment accumulation relationship: part_of GO:0043476 ! pigment accumulation [Term] id: GO:0043476 name: pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] synonym: "pigment accumulation in response to external stimulus" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0043473 ! pigmentation [Term] id: GO:0043477 name: pigment biosynthetic process involved in pigment accumulation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb] synonym: "pigment biosynthetic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043475 ! pigment metabolic process involved in pigment accumulation is_a: GO:0046148 ! pigment biosynthetic process intersection_of: GO:0046148 ! pigment biosynthetic process intersection_of: part_of GO:0043476 ! pigment accumulation [Term] id: GO:0043478 name: pigment accumulation in response to UV light namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0009411 ! response to UV is_a: GO:0043476 ! pigment accumulation [Term] id: GO:0043479 name: pigment accumulation in tissues in response to UV light namespace: biological_process def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0043478 ! pigment accumulation in response to UV light is_a: GO:0043480 ! pigment accumulation in tissues [Term] id: GO:0043480 name: pigment accumulation in tissues namespace: biological_process def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl] synonym: "organismal pigment accumulation" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0043476 ! pigment accumulation [Term] id: GO:0043481 name: anthocyanin accumulation in tissues in response to UV light namespace: biological_process def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light [Term] id: GO:0043482 name: cellular pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] is_a: GO:0033059 ! cellular pigmentation is_a: GO:0043476 ! pigment accumulation is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0043483 name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb] synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light" RELATED [GOC:dph, GOC:tb] synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] is_a: GO:0009718 ! anthocyanin-containing compound biosynthetic process is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation intersection_of: GO:0009718 ! anthocyanin-containing compound biosynthetic process intersection_of: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light [Term] id: GO:0043484 name: regulation of RNA splicing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] xref: MIPS_funcat:11.04.03.01.10 is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008380 ! RNA splicing relationship: regulates GO:0008380 ! RNA splicing [Term] id: GO:0043485 name: endosome to pigment granule transport namespace: biological_process def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl] is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0048757 ! pigment granule maturation [Term] id: GO:0043486 name: histone exchange namespace: biological_process def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. synonym: "histone chaperone" RELATED [GOC:vw] synonym: "histone replacement" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0043044 ! ATP-dependent chromatin remodeling relationship: has_part GO:0001207 ! histone displacement [Term] id: GO:0043487 name: regulation of RNA stability namespace: biological_process def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0006401 ! RNA catabolic process [Term] id: GO:0043488 name: regulation of mRNA stability namespace: biological_process def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] xref: MIPS_funcat:11.04.03.11 is_a: GO:0043487 ! regulation of RNA stability is_a: GO:0061013 ! regulation of mRNA catabolic process [Term] id: GO:0043489 name: RNA stabilization namespace: biological_process def: "Prevention of degradation of RNA molecules." [GOC:go_curators] is_a: GO:0043487 ! regulation of RNA stability is_a: GO:1902369 ! negative regulation of RNA catabolic process [Term] id: GO:0043490 name: malate-aspartate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663] synonym: "malate aspartate shuttle" EXACT [] synonym: "malate/aspartate shuttle" EXACT [] synonym: "malate:aspartate shuttle" EXACT [] xref: Wikipedia:Malate-aspartate_shuttle is_a: GO:1990542 ! mitochondrial transmembrane transport relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0043491 name: protein kinase B signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound." [GOC:bf, PMID:20517722] synonym: "AKT signal transduction" EXACT [GOC:signaling] synonym: "AKT signaling" EXACT [GOC:signaling] synonym: "AKT signaling cascade" RELATED [] synonym: "AKT signalling cascade" EXACT [] synonym: "PKB signal transduction" EXACT [GOC:signaling] synonym: "PKB signaling" EXACT [GOC:signaling] synonym: "PKB signaling cascade" RELATED [] synonym: "PKB signalling cascade" RELATED [] synonym: "protein kinase B signal transduction" EXACT [GOC:signaling] synonym: "protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase B signalling cascade" RELATED [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0043492 name: ATPase activity, coupled to movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] subset: gocheck_do_not_annotate xref: Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol" xref: Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12" is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0043493 name: viral terminase complex namespace: cellular_component def: "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides." [GOC:bf, GOC:bm, GOC:jl, GOC:mlg] synonym: "phage terminase complex" NARROW [GOC:bm] synonym: "virus terminase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0043494 name: CLRC ubiquitin ligase complex namespace: cellular_component def: "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi." [GOC:vw, PMID:16127433, PMID:20211136] synonym: "Clr4-Rik1-Cul4 complex" EXACT [] synonym: "CLRC complex" EXACT [] synonym: "Rik1 E3 ubiquitin ligase complex" EXACT [] synonym: "Rik1-E3 ubiquitin ligase complex" EXACT [] is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0031465 ! Cul4B-RING E3 ubiquitin ligase complex is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0043495 name: protein membrane adaptor namespace: molecular_function def: "Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location." [GOC:go_curators] synonym: "anchoring" RELATED [] synonym: "protein membrane anchor" RELATED [] is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0043496 name: regulation of protein homodimerization activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb] comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'. is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042803 ! protein homodimerization activity relationship: regulates GO:0042803 ! protein homodimerization activity [Term] id: GO:0043497 name: regulation of protein heterodimerization activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb] comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'. is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046982 ! protein heterodimerization activity relationship: regulates GO:0046982 ! protein heterodimerization activity [Term] id: GO:0043498 name: obsolete cell surface binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl] comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. synonym: "cell surface binding" EXACT [] is_obsolete: true consider: GO:0003823 consider: GO:0005102 consider: GO:0007155 consider: GO:0009986 consider: GO:0046812 [Term] id: GO:0043499 name: obsolete eukaryotic cell surface binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell." [GOC:jl] comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. synonym: "eukaryotic cell surface binding" EXACT [] is_obsolete: true consider: GO:0003823 consider: GO:0005102 consider: GO:0006952 consider: GO:0009986 consider: GO:0046812 [Term] id: GO:0043500 name: muscle adaptation namespace: biological_process def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] subset: goslim_pir synonym: "muscle plasticity" RELATED [] is_a: GO:0003012 ! muscle system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0043501 name: skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation [Term] id: GO:0043502 name: regulation of muscle adaptation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] synonym: "regulation of muscle plasticity" RELATED [] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043500 ! muscle adaptation relationship: regulates GO:0043500 ! muscle adaptation [Term] id: GO:0043503 name: skeletal muscle fiber adaptation namespace: biological_process def: "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle fiber plasticity" RELATED [] synonym: "skeletal muscle fibre plasticity" EXACT [] synonym: "skeletal myofiber plasticity" EXACT [] synonym: "skeletal myofibre plasticity" EXACT [] is_a: GO:0051716 ! cellular response to stimulus relationship: part_of GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0043504 name: mitochondrial DNA repair namespace: biological_process def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976] is_a: GO:0006281 ! DNA repair is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006281 ! DNA repair intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0043505 name: CENP-A containing nucleosome namespace: cellular_component def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641] synonym: "CenH3 containing nucleosome" EXACT [] synonym: "CENP-S-T-W-X" EXACT [GOC:vw, PMID:22304917] synonym: "centromere specific nucleosome" RELATED [] synonym: "centromere-specific nucleosome" RELATED [GOC:vw] synonym: "centromeric nucleosome" RELATED [] synonym: "CNP-T-W-S-X complex" EXACT [] is_a: GO:0000786 ! nucleosome relationship: part_of GO:0061638 ! CENP-A containing chromatin [Term] id: GO:0043506 name: regulation of JUN kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "regulation of JUNK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0046328 ! regulation of JNK cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004705 ! JUN kinase activity relationship: regulates GO:0004705 ! JUN kinase activity [Term] id: GO:0043507 name: positive regulation of JUN kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "positive regulation of JUNK activity" EXACT [] synonym: "stimulation of JNK activity" NARROW [] synonym: "up regulation of JNK activity" EXACT [] synonym: "up-regulation of JNK activity" EXACT [] synonym: "upregulation of JNK activity" EXACT [] is_a: GO:0043406 ! positive regulation of MAP kinase activity is_a: GO:0043506 ! regulation of JUN kinase activity is_a: GO:0046330 ! positive regulation of JNK cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004705 ! JUN kinase activity relationship: positively_regulates GO:0004705 ! JUN kinase activity [Term] id: GO:0043508 name: negative regulation of JUN kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl] synonym: "down regulation of JNK activity" EXACT [] synonym: "down-regulation of JNK activity" EXACT [] synonym: "downregulation of JNK activity" EXACT [] synonym: "inhibition of JNK activity" NARROW [] synonym: "negative regulation of JUNK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity is_a: GO:0043506 ! regulation of JUN kinase activity is_a: GO:0046329 ! negative regulation of JNK cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004705 ! JUN kinase activity relationship: negatively_regulates GO:0004705 ! JUN kinase activity [Term] id: GO:0043509 name: activin A complex namespace: cellular_component alt_id: GO:0048181 def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. is_a: GO:0048180 ! activin complex [Term] id: GO:0043510 name: activin B complex namespace: cellular_component alt_id: GO:0048182 def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. is_a: GO:0048180 ! activin complex [Term] id: GO:0043511 name: inhibin complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0043512 name: inhibin A complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. is_a: GO:0043511 ! inhibin complex [Term] id: GO:0043513 name: inhibin B complex namespace: cellular_component def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl] comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. is_a: GO:0043511 ! inhibin complex [Term] id: GO:0043514 name: interleukin-12 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512] comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. synonym: "IL-12 complex" EXACT [GOC:mah] synonym: "IL12A" NARROW [GOC:add] synonym: "IL12B" NARROW [GOC:add] synonym: "p35" NARROW [GOC:add] synonym: "p40" NARROW [GOC:add] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0043515 name: kinetochore binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/] is_a: GO:0005488 ! binding [Term] id: GO:0043516 name: regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "regulation of p53 induced by DNA damage response" EXACT [] is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043517 name: positive regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "positive regulation of p53 induced by DNA damage response" EXACT [] synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043518 name: negative regulation of DNA damage response, signal transduction by p53 class mediator namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW [] synonym: "negative regulation of p53 induced by DNA damage response" EXACT [] is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator [Term] id: GO:0043519 name: regulation of myosin II filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] synonym: "regulation of myosin II filament assembly or disassembly" RELATED [GOC:mah] synonym: "regulation of myosin II filament organisation" EXACT [GOC:mah] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031038 ! myosin II filament organization relationship: regulates GO:0031038 ! myosin II filament organization [Term] id: GO:0043520 name: regulation of myosin II filament assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0043519 ! regulation of myosin II filament organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031036 ! myosin II filament assembly relationship: regulates GO:0031036 ! myosin II filament assembly [Term] id: GO:0043521 name: regulation of myosin II filament disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0043519 ! regulation of myosin II filament organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031037 ! myosin II filament disassembly relationship: regulates GO:0031037 ! myosin II filament disassembly [Term] id: GO:0043522 name: leucine zipper domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158] synonym: "leucine zipper binding" EXACT [] is_a: GO:0030275 ! LRR domain binding [Term] id: GO:0043523 name: regulation of neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of neuronal cells" EXACT [] synonym: "regulation of apoptosis of neurons" EXACT [] synonym: "regulation of neuron apoptosis" NARROW [] synonym: "regulation of neuron programmed cell death" EXACT [] synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:1901214 ! regulation of neuron death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051402 ! neuron apoptotic process relationship: regulates GO:0051402 ! neuron apoptotic process [Term] id: GO:0043524 name: negative regulation of neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of neuron apoptosis" EXACT [] synonym: "down-regulation of neuron apoptosis" EXACT [] synonym: "downregulation of neuron apoptosis" EXACT [] synonym: "inhibition of neuron apoptosis" NARROW [] synonym: "negative regulation of neuron apoptosis" NARROW [] synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process is_a: GO:1901215 ! negative regulation of neuron death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process relationship: negatively_regulates GO:0051402 ! neuron apoptotic process [Term] id: GO:0043525 name: positive regulation of neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of neuron apoptosis" NARROW [] synonym: "positive regulation of neuron apoptosis" NARROW [] synonym: "positive regulation of programmed cell death, neurons" EXACT [] synonym: "stimulation of neuron apoptosis" NARROW [] synonym: "up regulation of neuron apoptosis" EXACT [] synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process is_a: GO:1901216 ! positive regulation of neuron death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051402 ! neuron apoptotic process relationship: positively_regulates GO:0051402 ! neuron apoptotic process [Term] id: GO:0043526 name: obsolete neuroprotection namespace: biological_process def: "OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [GOC:mtg_apoptosis, MSH:D017209, PMID:10208444, PMID:11909981, PMID:15905876] comment: This term was made obsolete because it refers to assays rather than processes. If neuron death by apoptosis is assessed, consider using GO:0043523 regulation of neuron apoptotic process. If neuron death is assessed but the cell death modality isn't defined, refer to GO:0070997 neuron death. Where non-neuronal cells are involved, and/or processes other than cell death are described, please use other terms for annotation. synonym: "neuroprotection" EXACT [] xref: Wikipedia:Neuroprotection is_obsolete: true [Term] id: GO:0043527 name: tRNA methyltransferase complex namespace: cellular_component def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972] subset: goslim_pir is_a: GO:0034708 ! methyltransferase complex [Term] id: GO:0043528 name: tRNA (m2G10) methyltransferase complex namespace: cellular_component def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842] is_a: GO:0043527 ! tRNA methyltransferase complex [Term] id: GO:0043529 name: GET complex namespace: cellular_component def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340] synonym: "Golgi to ER Traffic complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0043530 name: adenosine 5'-monophosphoramidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 5'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111] synonym: "adenosine 5' monophosphoramidase activity" EXACT [] synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT [] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043531 name: ADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [GOC:jl] synonym: "adenosine 5'-diphosphate binding" EXACT [] synonym: "adenosine diphosphate binding" EXACT [] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0043532 name: angiostatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] is_a: GO:0005515 ! protein binding [Term] id: GO:0043533 name: inositol 1,3,4,5 tetrakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators] synonym: "InsP4 binding" EXACT [] synonym: "IP4 binding" EXACT [] is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0043534 name: blood vessel endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] is_a: GO:0043542 ! endothelial cell migration [Term] id: GO:0043535 name: regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] is_a: GO:0010594 ! regulation of endothelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043534 ! blood vessel endothelial cell migration relationship: regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043536 name: positive regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "activation of blood vessel endothelial cell migration" NARROW [] synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043534 ! blood vessel endothelial cell migration relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043537 name: negative regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration [Term] id: GO:0043538 name: regulation of actin phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031289 ! actin phosphorylation relationship: regulates GO:0031289 ! actin phosphorylation [Term] id: GO:0043539 name: protein serine/threonine kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] synonym: "protein ser/thr kinase activator activity" EXACT [] is_a: GO:0030295 ! protein kinase activator activity relationship: part_of GO:0071902 ! positive regulation of protein serine/threonine kinase activity [Term] id: GO:0043540 name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex namespace: cellular_component def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so] comment: Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future. synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex" NARROW [] synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex" NARROW [] synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex" NARROW [] synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex" NARROW [] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0043541 name: UDP-N-acetylglucosamine transferase complex namespace: cellular_component def: "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246] comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0043542 name: endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators] is_a: GO:0010631 ! epithelial cell migration [Term] id: GO:0043543 name: protein acylation namespace: biological_process def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] subset: goslim_yeast synonym: "protein amino acid acylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0043544 name: lipoamide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] xref: MIPS_funcat:16.21.13 is_a: GO:0033218 ! amide binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043545 name: molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco metabolic process" EXACT [] synonym: "Moco metabolism" EXACT [] synonym: "molybdopterin cofactor metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0051189 ! prosthetic group metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0043546 name: molybdopterin cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco binding" EXACT [] xref: MIPS_funcat:16.21.03 is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0043547 name: positive regulation of GTPase activity namespace: biological_process alt_id: GO:0032320 alt_id: GO:0032321 alt_id: GO:0032850 alt_id: GO:0032851 alt_id: GO:0032852 alt_id: GO:0032853 alt_id: GO:0032854 alt_id: GO:0032855 alt_id: GO:0043089 def: "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] synonym: "activation of GTPase activity" NARROW [] synonym: "positive regulation of ARF GTPase activity" NARROW [] synonym: "positive regulation of Cdc42 GTPase activity" NARROW [] synonym: "positive regulation of Rab GTPase activity" NARROW [] synonym: "positive regulation of Rac GTPase activity" NARROW [] synonym: "positive regulation of Ral GTPase activity" NARROW [] synonym: "positive regulation of Ran GTPase activity" NARROW [] synonym: "positive regulation of Rap GTPase activity" NARROW [] synonym: "positive regulation of Ras GTPase activity" NARROW [] synonym: "positive regulation of Rho GTPase activity" NARROW [] synonym: "stimulation of ARF GTPase activity" NARROW [] synonym: "stimulation of Cdc42 GTPase activity" NARROW [] synonym: "stimulation of GTPase activity" NARROW [] synonym: "stimulation of Rab GTPase activity" NARROW [] synonym: "stimulation of Rac GTPase activity" NARROW [] synonym: "stimulation of Ral GTPase activity" NARROW [] synonym: "stimulation of Ran GTPase activity" NARROW [] synonym: "stimulation of Rap GTPase activity" NARROW [] synonym: "stimulation of Ras GTPase activity" NARROW [] synonym: "stimulation of Rho GTPase activity" NARROW [] synonym: "up regulation of ARF GTPase activity" NARROW [] synonym: "up regulation of Cdc42 GTPase activity" NARROW [] synonym: "up regulation of GTPase activity" EXACT [] synonym: "up regulation of Rab GTPase activity" NARROW [] synonym: "up regulation of Rac GTPase activity" NARROW [] synonym: "up regulation of Ral GTPase activity" NARROW [] synonym: "up regulation of Ran GTPase activity" NARROW [] synonym: "up regulation of Rap GTPase activity" NARROW [] synonym: "up regulation of Ras GTPase activity" NARROW [] synonym: "up regulation of Rho GTPase activity" NARROW [] synonym: "up-regulation of ARF GTPase activity" NARROW [] synonym: "up-regulation of Cdc42 GTPase activity" NARROW [] synonym: "up-regulation of GTPase activity" EXACT [] synonym: "up-regulation of Rab GTPase activity" NARROW [] synonym: "up-regulation of Rac GTPase activity" NARROW [] synonym: "up-regulation of Ral GTPase activity" NARROW [] synonym: "up-regulation of Ran GTPase activity" NARROW [] synonym: "up-regulation of Rap GTPase activity" NARROW [] synonym: "up-regulation of Ras GTPase activity" NARROW [] synonym: "up-regulation of Rho GTPase activity" NARROW [] synonym: "upregulation of ARF GTPase activity" NARROW [] synonym: "upregulation of Cdc42 GTPase activity" NARROW [] synonym: "upregulation of GTPase activity" EXACT [] synonym: "upregulation of Rab GTPase activity" NARROW [] synonym: "upregulation of Rac GTPase activity" NARROW [] synonym: "upregulation of Ral GTPase activity" NARROW [] synonym: "upregulation of Ran GTPase activity" NARROW [] synonym: "upregulation of Rap GTPase activity" NARROW [] synonym: "upregulation of Ras GTPase activity" NARROW [] synonym: "upregulation of Rho GTPase activity" NARROW [] xref: MIPS_funcat:18.02.01.01.01 is_a: GO:0043087 ! regulation of GTPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003924 ! GTPase activity relationship: positively_regulates GO:0003924 ! GTPase activity [Term] id: GO:0043548 name: phosphatidylinositol 3-kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] synonym: "phosphoinositide 3-kinase binding" EXACT [] synonym: "PI3K binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043549 name: regulation of kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016301 ! kinase activity relationship: regulates GO:0016301 ! kinase activity [Term] id: GO:0043550 name: regulation of lipid kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001727 ! lipid kinase activity relationship: regulates GO:0001727 ! lipid kinase activity [Term] id: GO:0043551 name: regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf] synonym: "regulation of phosphoinositide 3-kinase activity" EXACT [] is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity relationship: regulates GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0043552 name: positive regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] synonym: "activation of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "positive regulation of phosphoinositide 3-kinase activity" EXACT [] synonym: "stimulation of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "up regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "up-regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "upregulation of phosphatidylinositol 3-kinase activity" EXACT [] is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity relationship: positively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0043553 name: negative regulation of phosphatidylinositol 3-kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] synonym: "down regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "down-regulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "downregulation of phosphatidylinositol 3-kinase activity" EXACT [] synonym: "inhibition of phosphatidylinositol 3-kinase activity" NARROW [] synonym: "negative regulation of phosphoinositide 3-kinase activity" EXACT [] synonym: "negative regulation of PI3K activity" EXACT [GOC:bf] is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity relationship: negatively_regulates GO:0035004 ! phosphatidylinositol 3-kinase activity [Term] id: GO:0043554 name: aerobic respiration, using arsenite as electron donor namespace: biological_process def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0043555 name: regulation of translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] synonym: "translational stress response" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0043556 name: regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0043555 ! regulation of translation in response to stress relationship: part_of GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0043557 name: regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0043558 name: regulation of translational initiation in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0043559 name: insulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732] is_a: GO:0005515 ! protein binding is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0043560 name: insulin receptor substrate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233] synonym: "insulin receptor substrate [protein] binding" EXACT [] synonym: "IRS [protein] binding" EXACT [] synonym: "IRS binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043561 name: regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb] is_a: GO:0043557 ! regulation of translation in response to osmotic stress is_a: GO:0043558 ! regulation of translational initiation in response to stress [Term] id: GO:0043562 name: cellular response to nitrogen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl] is_a: GO:0031669 ! cellular response to nutrient levels [Term] id: GO:0043563 name: obsolete odorant transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl] is_obsolete: true [Term] id: GO:0043564 name: Ku70:Ku80 complex namespace: cellular_component def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] synonym: "Ku70:Ku80 heterodimer" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0043565 name: sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] synonym: "sequence specific DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0043567 name: regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "regulation of IGF receptor signaling pathway" EXACT [] synonym: "regulation of IGF receptor signalling pathway" EXACT [] synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043568 name: positive regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of IGF receptor signaling pathway" EXACT [] synonym: "positive regulation of IGF receptor signalling pathway" EXACT [] synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT [] synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043569 name: negative regulation of insulin-like growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of IGF receptor signaling pathway" EXACT [] synonym: "negative regulation of IGF receptor signalling pathway" EXACT [] synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0043570 name: maintenance of DNA repeat elements namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0051276 ! chromosome organization [Term] id: GO:0043571 name: maintenance of CRISPR repeat elements namespace: biological_process def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354] synonym: "CRISPR element metabolic process" RELATED [] synonym: "CRISPR element metabolism" RELATED [] synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT [] is_a: GO:0043570 ! maintenance of DNA repeat elements [Term] id: GO:0043572 name: plastid fission namespace: biological_process def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] is_a: GO:0048285 ! organelle fission [Term] id: GO:0043573 name: leucoplast fission namespace: biological_process def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl] is_a: GO:0043572 ! plastid fission [Term] id: GO:0043574 name: peroxisomal transport namespace: biological_process def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] xref: MIPS_funcat:20.09.10 is_a: GO:0046907 ! intracellular transport [Term] id: GO:0043575 name: detection of osmotic stimulus namespace: biological_process def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl] xref: MIPS_funcat:34.11.03.13 is_a: GO:0006970 ! response to osmotic stress is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] xref: MIPS_funcat:36.07.03 is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system [Term] id: GO:0043577 name: chemotropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613] xref: MIPS_funcat:36.20.35.09.07 xref: Wikipedia:Chemotropism is_a: GO:0009606 ! tropism intersection_of: GO:0009606 ! tropism intersection_of: part_of GO:0042221 ! response to chemical relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0043578 name: nuclear matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "nuclear matrix organisation" EXACT [] synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah] synonym: "nucleoskeleton organization" EXACT [GOC:tb] xref: MIPS_funcat:42.10.06 is_a: GO:0006997 ! nucleus organization [Term] id: GO:0043579 name: elaioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl] synonym: "elaioplast organisation" EXACT [] synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.26.09 is_a: GO:0009659 ! leucoplast organization [Term] id: GO:0043580 name: periplasmic space organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah] synonym: "periplasmic space organisation" EXACT [GOC:mah] synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] xref: MIPS_funcat:42.28 is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043581 name: obsolete mycelium development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae." [GOC:jl, ISBN:1580085792, PMID:12832397] comment: The reason for obsoletion is that the term is ambiguous. Three more clearly defined terms have been created that should be considered in its place. xref: MIPS_funcat:41.01.03.03 xref: MIPS_funcat:43.01.02.01 is_obsolete: true consider: GO:0097736 consider: GO:0097737 consider: GO:0097738 [Term] id: GO:0043582 name: sporangium development namespace: biological_process def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium] synonym: "sporangia development" EXACT [] xref: MIPS_funcat:43.01.02.02 is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0043583 name: ear development namespace: biological_process def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] synonym: "hearing organ development" EXACT [] xref: MIPS_funcat:47.03.02.01 is_a: GO:0007423 ! sensory organ development [Term] id: GO:0043584 name: nose development namespace: biological_process def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] synonym: "nasus development" EXACT [] xref: MIPS_funcat:47.03.02.03 is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0043585 name: nose morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] synonym: "nasus morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0043584 ! nose development [Term] id: GO:0043586 name: tongue development namespace: biological_process def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa development" NARROW [] synonym: "lingua development" NARROW [] xref: MIPS_funcat:47.03.02.04 is_a: GO:0007423 ! sensory organ development [Term] id: GO:0043587 name: tongue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa morphogenesis" NARROW [] synonym: "lingua morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0043586 ! tongue development [Term] id: GO:0043588 name: skin development namespace: biological_process def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] synonym: "animal skin development" EXACT [] xref: MIPS_funcat:47.03.02.05 is_a: GO:0048513 ! animal organ development [Term] id: GO:0043589 name: skin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0043588 ! skin development [Term] id: GO:0043590 name: bacterial nucleoid namespace: cellular_component def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] xref: MIPS_funcat:42.37 xref: MIPS_funcat:70.37 is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0043591 name: endospore external encapsulating structure namespace: cellular_component alt_id: GO:0055030 def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041] subset: goslim_pir synonym: "endospore wall" EXACT [GOC:mah] synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu] synonym: "spore wall" BROAD [GOC:mtg_sensu] is_a: GO:0031160 ! spore wall [Term] id: GO:0043592 name: exosporium namespace: cellular_component def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg] synonym: "epispore" RELATED [] synonym: "exospore" RELATED [] synonym: "perispore" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043593 name: endospore coat namespace: cellular_component def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg] xref: MIPS_funcat:42.34.09 xref: MIPS_funcat:70.34.09 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043594 name: outer endospore membrane namespace: cellular_component def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg] is_a: GO:0019867 ! outer membrane intersection_of: GO:0019867 ! outer membrane intersection_of: part_of GO:0043591 ! endospore external encapsulating structure relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043595 name: endospore cortex namespace: cellular_component def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043591 ! endospore external encapsulating structure [Term] id: GO:0043596 name: nuclear replication fork namespace: cellular_component def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] is_a: GO:0005657 ! replication fork intersection_of: GO:0005657 ! replication fork intersection_of: part_of GO:0005634 ! nucleus relationship: has_part GO:0071162 ! CMG complex relationship: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0043597 name: cytoplasmic replication fork namespace: cellular_component def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] is_a: GO:0005657 ! replication fork intersection_of: GO:0005657 ! replication fork intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0043598 name: cytoplasmic DNA replication factor C complex namespace: cellular_component def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520] synonym: "cytoplasmic clamp loader" EXACT [] synonym: "cytoplasmic RFC" EXACT [] is_a: GO:0005663 ! DNA replication factor C complex intersection_of: GO:0005663 ! DNA replication factor C complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0043600 ! cytoplasmic replisome [Term] id: GO:0043599 name: nuclear DNA replication factor C complex namespace: cellular_component def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842] synonym: "nuclear RFC" EXACT [] is_a: GO:0005663 ! DNA replication factor C complex intersection_of: GO:0005663 ! DNA replication factor C complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0043600 name: cytoplasmic replisome namespace: cellular_component def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu] synonym: "prokaryotic replisome" EXACT [] is_a: GO:0030894 ! replisome intersection_of: GO:0030894 ! replisome intersection_of: part_of GO:0005737 ! cytoplasm relationship: has_part GO:0009360 ! DNA polymerase III complex relationship: has_part GO:0044777 ! single-stranded DNA-binding protein complex relationship: part_of GO:0043597 ! cytoplasmic replication fork [Term] id: GO:0043601 name: nuclear replisome namespace: cellular_component def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] is_a: GO:0030894 ! replisome intersection_of: GO:0030894 ! replisome intersection_of: part_of GO:0005634 ! nucleus relationship: has_part GO:0008622 ! epsilon DNA polymerase complex relationship: part_of GO:0043596 ! nuclear replication fork [Term] id: GO:0043602 name: nitrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] synonym: "nitrate disassimilation" EXACT [] synonym: "nitrate dissimilation" EXACT [] xref: MIPS_funcat:01.02.01.03 is_a: GO:0042126 ! nitrate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0043603 name: cellular amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] subset: goslim_pir synonym: "amide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0043605 name: cellular amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0043606 name: formamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] synonym: "formamide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0043607 name: formamide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0043606 ! formamide metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0043608 name: formamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] xref: MIPS_funcat:01.02.01.09.07 is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0043606 ! formamide metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0043609 name: regulation of carbon utilization namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl] xref: MIPS_funcat:01.05.04 is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015976 ! carbon utilization relationship: regulates GO:0015976 ! carbon utilization [Term] id: GO:0043610 name: regulation of carbohydrate utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl] synonym: "regulation of sugar utilization" NARROW [GOC:mcc2] xref: MIPS_funcat:01.05.04 is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009758 ! carbohydrate utilization relationship: regulates GO:0009758 ! carbohydrate utilization [Term] id: GO:0043611 name: isoprene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl] synonym: "2-methyl-1,3-butadiene metabolic process" EXACT [] synonym: "2-methyl-1,3-butadiene metabolism" EXACT [] synonym: "hemiterpene metabolic process" EXACT [] synonym: "hemiterpene metabolism" EXACT [] synonym: "isoprene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process is_a: GO:1900673 ! olefin metabolic process [Term] id: GO:0043612 name: isoprene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl] synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT [] synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT [] synonym: "hemiterpene biosynthesis" EXACT [] synonym: "hemiterpene biosynthetic process" EXACT [] xref: MIPS_funcat:01.06.01.07.01 is_a: GO:0043611 ! isoprene metabolic process is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process [Term] id: GO:0043613 name: isoprene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl] synonym: "2-methyl-1,3-butadiene catabolic process" EXACT [] synonym: "2-methyl-1,3-butadiene catabolism" EXACT [] synonym: "hemiterpene catabolic process" EXACT [] synonym: "hemiterpene catabolism" EXACT [] is_a: GO:0043611 ! isoprene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0043614 name: multi-eIF complex namespace: cellular_component def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc] synonym: "multifactor translation initiation factor (eIF) complex" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0043615 name: astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] synonym: "astrocyte migration" EXACT [] synonym: "astrocytic glial cell migration" EXACT [] is_a: GO:0008347 ! glial cell migration [Term] id: GO:0043616 name: keratinocyte proliferation namespace: biological_process def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0043617 name: cellular response to sucrose starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0043618 name: regulation of transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0043620 ! regulation of DNA-templated transcription in response to stress [Term] id: GO:0043619 name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress relationship: part_of GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0043620 name: regulation of DNA-templated transcription in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH] synonym: "regulation of DNA-dependent transcription in response to stress" EXACT [GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0043621 name: protein self-association namespace: molecular_function def: "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] subset: goslim_chembl synonym: "intramolecular protein binding" EXACT [] synonym: "protein self association" EXACT [] synonym: "protein self binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0043622 name: cortical microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] synonym: "cortical microtubule cytoskeleton organization" EXACT [] synonym: "cortical microtubule organisation" EXACT [] synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030865 ! cortical cytoskeleton organization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0043624 name: cellular protein complex disassembly namespace: biological_process def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0043625 name: delta DNA polymerase complex namespace: cellular_component alt_id: GO:0005659 def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] synonym: "delta-DNA polymerase complex" EXACT [] is_a: GO:0042575 ! DNA polymerase complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0043626 name: PCNA complex namespace: cellular_component def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] synonym: "PCNA homotrimer" EXACT [] synonym: "proliferating cell nuclear antigen complex" EXACT [] synonym: "sliding clamp" BROAD [] is_a: GO:0044796 ! DNA polymerase processivity factor complex [Term] id: GO:0043627 name: response to estrogen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732] synonym: "response to estrogen stimulus" EXACT [GOC:dos] synonym: "response to oestrogen stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0043628 name: ncRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl] synonym: "ncRNA 3' end processing" EXACT [] is_a: GO:0031123 ! RNA 3'-end processing is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0043629 name: ncRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092] synonym: "non-coding RNA polyadenylation" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0043630 name: ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb] synonym: "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] is_a: GO:0043629 ! ncRNA polyadenylation relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process [Term] id: GO:0043631 name: RNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0043632 name: modification-dependent macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0043633 name: polyadenylation-dependent RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc] synonym: "polyadenylation-dependent RNA catabolic process" RELATED [GOC:vw] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0043632 ! modification-dependent macromolecule catabolic process [Term] id: GO:0043634 name: polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc] synonym: "poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process relationship: has_part GO:0043629 ! ncRNA polyadenylation [Term] id: GO:0043635 name: methylnaphthalene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687] synonym: "1-methylnaphthalene catabolic process" NARROW [] synonym: "1-methylnaphthalene catabolism" NARROW [] synonym: "1-MN catabolic process" RELATED [] synonym: "1-MN catabolism" RELATED [] synonym: "2-methylnaphthalene catabolic process" NARROW [] synonym: "2-methylnaphthalene catabolism" NARROW [] synonym: "2-MN catabolic process" RELATED [] synonym: "2-MN catabolism" RELATED [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0090420 ! naphthalene-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0043636 name: bisphenol A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [GOC:jl, Wikipedia:Bisphenol_A] synonym: "bisphenol-A catabolic process" EXACT [] synonym: "bisphenol-A catabolism" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0043637 name: puromycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, PMID:8226694, Wikipedia:Puromycin] synonym: "puromycin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0043638 name: puromycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, Wikipedia:Puromycin] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043637 ! puromycin metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0043639 name: benzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl] synonym: "benzoate breakdown" EXACT [] synonym: "benzoate catabolism" EXACT [] synonym: "benzoate degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0043640 name: benzoate catabolic process via hydroxylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503] synonym: "benzoate breakdown via hydroxylation" EXACT [] synonym: "benzoate degradation via hydroxylation" EXACT [] xref: MetaCyc:PWY-2503 is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0043641 name: novobiocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl] synonym: "novobiocin metabolism" EXACT [] xref: Wikipedia:Novobiocin is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0043642 name: novobiocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl] xref: Wikipedia:Novobiocin is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0043641 ! novobiocin metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0043643 name: tetracycline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline] synonym: "tetracyclin metabolic process" EXACT [] synonym: "tetracyclin metabolism" EXACT [] synonym: "tetracycline metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process [Term] id: GO:0043644 name: tetracycline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline] synonym: "tetracyclin biosynthesis" EXACT [] synonym: "tetracyclin biosynthetic process" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043643 ! tetracycline metabolic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0043645 name: cephalosporin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin] synonym: "cephalosporin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process [Term] id: GO:0043646 name: cephalosporin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin] is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:0043645 ! cephalosporin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0043647 name: inositol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:jl] synonym: "inositol phosphate metabolism" EXACT [] synonym: "myo-inositol phosphate metabolic process" NARROW [] synonym: "myo-inositol phosphate metabolism" NARROW [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0019751 ! polyol metabolic process [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0043649 name: dicarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate catabolic process" EXACT [] synonym: "dicarboxylate catabolism" EXACT [] synonym: "dicarboxylic acid breakdown" EXACT [] synonym: "dicarboxylic acid catabolism" EXACT [] synonym: "dicarboxylic acid degradation" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate biosynthesis" EXACT [] synonym: "dicarboxylate biosynthetic process" EXACT [] synonym: "dicarboxylic acid anabolism" EXACT [] synonym: "dicarboxylic acid biosynthesis" EXACT [] synonym: "dicarboxylic acid formation" EXACT [] synonym: "dicarboxylic acid synthesis" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0043651 name: linoleic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid] synonym: "linoleic acid metabolism" EXACT [] xref: Wikipedia:Linoleic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0043652 name: engulfment of apoptotic cell namespace: biological_process def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015] comment: This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'. synonym: "engulfment of apoptotic cell corpse" EXACT [] synonym: "engulfment of cell corpse" EXACT [] is_a: GO:0006911 ! phagocytosis, engulfment relationship: part_of GO:0043277 ! apoptotic cell clearance [Term] id: GO:0043653 name: mitochondrial fragmentation involved in apoptotic process namespace: biological_process def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994] comment: Although most of the processes described under 'apoptotic mitochondrial changes' take place during the signaling phase of apoptosis, 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed there. It is still controversial whether this process is involved in the signaling phase of apoptosis or not, so it was placed under the more generic 'apoptotic mitochondrial changes' parent rather than linked to the signaling or the execution phase until further research clarifies the matter. synonym: "mitochondrial fission during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "mitochondrial fragmentation involved in apoptosis" NARROW [] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0043654 name: recognition of apoptotic cell namespace: biological_process def: "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015] synonym: "detection of apoptotic cell" EXACT [] synonym: "detection of apoptotic cell corpse" EXACT [] synonym: "detection of cell corpse" EXACT [] synonym: "recognition of apoptotic cell corpse" EXACT [] synonym: "recognition of cell corpse" EXACT [] is_a: GO:0006910 ! phagocytosis, recognition relationship: part_of GO:0043277 ! apoptotic cell clearance [Term] id: GO:0043655 name: host extracellular space namespace: cellular_component def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] synonym: "extracellular space of host" EXACT [] synonym: "host extracellular space" EXACT [] is_a: GO:0018995 ! host cellular component [Term] id: GO:0043656 name: host intracellular region namespace: cellular_component def: "That space within the plasma membrane of a host cell." [GOC:cc] synonym: "host intracellular" EXACT [] synonym: "intracellular region of host" EXACT [] is_a: GO:0033643 ! host cell part [Term] id: GO:0043657 name: host cell namespace: cellular_component def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] is_a: GO:0018995 ! host cellular component [Term] id: GO:0043658 name: host symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0043659 name: symbiosome namespace: cellular_component def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc] is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0043660 name: bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc] is_a: GO:0043659 ! symbiosome [Term] id: GO:0043661 name: peribacteroid membrane namespace: cellular_component def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0043662 name: peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0043663 name: host bacteroid-containing symbiosome namespace: cellular_component def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc] is_a: GO:0043658 ! host symbiosome [Term] id: GO:0043664 name: host peribacteroid membrane namespace: cellular_component def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] is_a: GO:0033643 ! host cell part relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome [Term] id: GO:0043665 name: host peribacteroid fluid namespace: cellular_component def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc] is_a: GO:0033643 ! host cell part relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome [Term] id: GO:0043666 name: regulation of phosphoprotein phosphatase activity namespace: biological_process alt_id: GO:0032512 alt_id: GO:0034047 def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821] synonym: "regulation of calcineurin activity" NARROW [] synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "regulation of protein phosphatase type 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "regulation of protein phosphatase type 2A activity" NARROW [] synonym: "regulation of protein phosphatase type 2B activity" NARROW [] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0035304 ! regulation of protein dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004721 ! phosphoprotein phosphatase activity relationship: regulates GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0043667 name: pollen wall namespace: cellular_component def: "The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine." [GOC:fz, PMID:15131249] synonym: "microspore wall" EXACT [] is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0043668 name: exine namespace: cellular_component def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the exine is highly resistant to strong acids and bases. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043667 ! pollen wall [Term] id: GO:0043669 name: ectexine namespace: cellular_component def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043668 ! exine [Term] id: GO:0043670 name: foot layer namespace: cellular_component def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "nexine 1" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043669 ! ectexine [Term] id: GO:0043671 name: endexine namespace: cellular_component def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043668 ! exine [Term] id: GO:0043672 name: nexine namespace: cellular_component def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043668 ! exine [Term] id: GO:0043673 name: sexine namespace: cellular_component def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043668 ! exine [Term] id: GO:0043674 name: columella namespace: cellular_component def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 1" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043675 name: sculpture element namespace: cellular_component def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043676 name: tectum namespace: cellular_component def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/] synonym: "sexine 2" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043673 ! sexine [Term] id: GO:0043677 name: obsolete germination pore namespace: cellular_component def: "OBSOLETE. A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore] comment: This term was made obsolete because it was poorly named and poorly defined. synonym: "germ pore" EXACT [] xref: Wikipedia:Germ_pore is_obsolete: true [Term] id: GO:0043678 name: intine namespace: cellular_component def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/] comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043667 ! pollen wall [Term] id: GO:0043679 name: axon terminus namespace: cellular_component def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl] synonym: "axon terminal" EXACT [NIF_Subcellular:sao2007137787] synonym: "axon terminal specialization" RELATED [] synonym: "nerve ending" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090512 is_a: GO:0044306 ! neuron projection terminus is_a: GO:0098793 ! presynapse relationship: part_of GO:0150034 ! distal axon [Term] id: GO:0043680 name: filiform apparatus namespace: cellular_component def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005618 ! cell wall [Term] id: GO:0043682 name: copper transmembrane transporter activity, phosphorylative mechanism namespace: molecular_function alt_id: GO:0004008 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [EC:7.2.2.9] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-exporting ATPase activity" RELATED [] synonym: "copper-translocating P-type ATPase activity" RELATED [] synonym: "copper-transporting ATPase activity" EXACT [] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:7.2.2.9] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:7.2.2.9] xref: EC:7.2.2.9 xref: MetaCyc:3.6.3.4-RXN xref: Reactome:R-HSA-3697838 "ATP7A transfers Cu from ATOX1 to SOD3" xref: Reactome:R-HSA-6803545 "ATP7A transports cytosolic Cu2+ to phagosomal lumen" xref: Reactome:R-HSA-936802 "ATP7A transports cytosolic Cu2+ to extracellular region" xref: Reactome:R-HSA-936895 "ATP7B transports cytosolic Cu2+ to Golgi lumen" xref: RHEA:10376 is_a: GO:0005375 ! copper ion transmembrane transporter activity is_a: GO:0015662 ! ion transmembrane transporter activity, phosphorylative mechanism is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0043683 name: type IV pilus biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a type IV pilus. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:jl, GOC:ml] synonym: "TFP biogenesis" EXACT [] synonym: "type 4 pilus biogenesis" EXACT [] synonym: "type IV fimbria assembly" EXACT [] synonym: "type IV fimbria biogenesis" EXACT [] synonym: "type IV fimbriae assembly" EXACT [] synonym: "type IV fimbriae biogenesis" EXACT [] synonym: "type IV fimbrial assembly" EXACT [] synonym: "type IV fimbrial biogenesis" EXACT [] synonym: "type IV fimbrium assembly" EXACT [] synonym: "type IV fimbrium biogenesis" EXACT [] synonym: "type IV pilus biosynthesis" EXACT [] is_a: GO:0009297 ! pilus assembly is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0043684 name: type IV secretion system complex namespace: cellular_component def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml] synonym: "T4SS complex" EXACT [] synonym: "type IV protein secretion system complex" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0043685 name: conversion of glutamyl-tRNA to glutaminyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308] comment: Note that this process has been observed in some archaeal and bacterial species. is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0043686 name: co-translational protein modification namespace: biological_process def: "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg] comment: This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome. synonym: "co-translational amino acid modification" EXACT [] synonym: "co-translational modification" EXACT [] synonym: "cotranslational amino acid modification" EXACT [] synonym: "cotranslational modification" EXACT [] synonym: "cotranslational protein modification" EXACT [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0043687 name: post-translational protein modification namespace: biological_process def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term. synonym: "post-translational amino acid modification" EXACT [] synonym: "post-translational modification" EXACT [] synonym: "posttranslational amino acid modification" EXACT [] synonym: "posttranslational modification" EXACT [] synonym: "posttranslational protein modification" EXACT [] synonym: "PTM" EXACT [] xref: Wikipedia:Posttranslational_modification is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0043688 name: conversion of aspartyl-tRNA to asparaginyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001] comment: Note that this process has been observed in some archaeal and bacterial species. is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0043689 name: cell-cell adhesion involved in flocculation namespace: biological_process def: "The attachment of one single cell organism to another via adhesion molecules, occurring as a part of flocculation." [GOC:dos, GOC:jl] is_a: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0000128 ! flocculation relationship: part_of GO:0000128 ! flocculation [Term] id: GO:0043690 name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The attachment of one single cell organism to another during flocculation via the interaction a protein in the cell wall of one cell with a carbohydrate in the cell wall of another In Saccharomyces this process is mannose-sensitive." [GOC:dos, GOC:jl] is_a: GO:0043689 ! cell-cell adhesion involved in flocculation intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction [Term] id: GO:0043691 name: reverse cholesterol transport namespace: biological_process def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809] is_a: GO:0030301 ! cholesterol transport [Term] id: GO:0043692 name: monoterpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene] synonym: "monoterpene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0043693 name: monoterpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene] synonym: "monoterpene biosynthesis" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0043694 name: monoterpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [PMID:25076942] synonym: "monoterpene catabolism" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0043695 name: detection of pheromone namespace: biological_process def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0019236 ! response to pheromone [Term] id: GO:0043696 name: dedifferentiation namespace: biological_process def: "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg] xref: Wikipedia:Cellular_differentiation#Dedifferentiation is_a: GO:0032502 ! developmental process [Term] id: GO:0043697 name: cell dedifferentiation namespace: biological_process def: "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer. is_a: GO:0043696 ! dedifferentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0043698 name: iridosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh] synonym: "reflecting platelet" EXACT [] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043699 name: leucosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh] synonym: "refractosome" EXACT [] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043700 name: pterinosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043701 name: cyanosome namespace: cellular_component def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh] is_a: GO:0048770 ! pigment granule [Term] id: GO:0043702 name: carotenoid vesicle namespace: cellular_component def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0043703 name: photoreceptor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] is_a: GO:0048664 ! neuron fate determination relationship: part_of GO:0046552 ! photoreceptor cell fate commitment [Term] id: GO:0043704 name: photoreceptor cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0046552 ! photoreceptor cell fate commitment [Term] id: GO:0043705 name: cyanophycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl] synonym: "cyanophycin metabolism" EXACT [] synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043706 name: heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein namespace: biological_process def: "The attachment of an erythrocyte to the microvasculature via a parasite cell adhesion molecule. This may be via attachment to host endothelial cell ECM or to endothelial cell adhesion molecules. An example of this occurs during infection with the malaria parasite." [GOC:jl, PMID:10362584, PMID:23376131] is_a: GO:0098740 ! multi organism cell adhesion relationship: part_of GO:0020035 ! cytoadherence to microvasculature, mediated by symbiont protein [Term] id: GO:0043707 name: cell adhesion involved in single-species biofilm formation in or on host organism namespace: biological_process def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species." [GOC:jl] synonym: "cell adhesion during single-species biofilm formation in or on host organism" RELATED [GOC:dph] is_a: GO:0043709 ! cell adhesion involved in single-species biofilm formation intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0044407 ! single-species biofilm formation in or on host organism relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism [Term] id: GO:0043708 name: cell adhesion involved in biofilm formation namespace: biological_process def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031589 ! cell-substrate adhesion intersection_of: GO:0031589 ! cell-substrate adhesion intersection_of: part_of GO:0042710 ! biofilm formation relationship: part_of GO:0090605 ! submerged biofilm formation [Term] id: GO:0043709 name: cell adhesion involved in single-species biofilm formation namespace: biological_process def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during single-species biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043708 ! cell adhesion involved in biofilm formation intersection_of: GO:0031589 ! cell-substrate adhesion intersection_of: part_of GO:0044010 ! single-species biofilm formation relationship: part_of GO:0090609 ! single-species submerged biofilm formation [Term] id: GO:0043710 name: cell adhesion involved in multi-species biofilm formation namespace: biological_process def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb] synonym: "cell adhesion during multi-species biofilm formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043708 ! cell adhesion involved in biofilm formation intersection_of: GO:0031589 ! cell-substrate adhesion intersection_of: part_of GO:0044399 ! multi-species biofilm formation relationship: part_of GO:0090608 ! multi-species submerged biofilm formation [Term] id: GO:0043711 name: pilus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl] synonym: "pilus organisation" EXACT [GOC:mah] synonym: "pilus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030030 ! cell projection organization [Term] id: GO:0043712 name: 2-hydroxyisocaproate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate." [PMID:16957230] synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [] synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043713 name: (R)-2-hydroxyisocaproate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043714 name: (R)-citramalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346] synonym: "citramalate synthase" BROAD [] xref: EC:2.3.1.182 xref: MetaCyc:RXN-7743 xref: RHEA:19045 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0043715 name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN] comment: This function is part of the process of methionine salvage. synonym: "DK-MTP-1-P enolase activity" EXACT [] synonym: "E-1" RELATED [] synonym: "MasA" RELATED [] synonym: "mtnW" RELATED [] xref: EC:5.3.2.5 xref: MetaCyc:R82-RXN xref: RHEA:18769 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0043716 name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, IMG:01681, MetaCyc:R83-RXN] synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN] synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] xref: KEGG_REACTION:R07394 xref: MetaCyc:R83-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043717 name: 2-hydroxyglutaryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083] synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] xref: MetaCyc:RXN-1083 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043718 name: 2-hydroxymethylglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH." [EC:1.1.1.291, RHEA:15505] synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291] synonym: "HgD" EXACT [] xref: EC:1.1.1.291 xref: KEGG_REACTION:R07985 xref: MetaCyc:1.1.1.291-RXN xref: RHEA:15505 xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043719 name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] xref: EC:1.14.13 xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043720 name: 3-keto-5-aminohexanoate cleavage activity namespace: molecular_function def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064] synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] xref: MetaCyc:R125-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043721 name: 4-hydroxybutanoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O." [EC:4.2.1.120] synonym: "4-hydroxybutanoyl-CoA hydro-lyase" EXACT [] synonym: "4-hydroxybutyryl-CoA dehydratase activity" EXACT [] synonym: "gamma-hydroxybutanoyl-CoA dehydratase activity" EXACT [] synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT [] xref: EC:4.2.1.120 xref: KEGG_REACTION:R05337 xref: MetaCyc:RXN-8890 xref: RHEA:26530 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043722 name: 4-hydroxyphenylacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2)." [EC:4.1.1.83, RHEA:22732] synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83] synonym: "4-Hpd activity" EXACT [EC:4.1.1.83] synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83] synonym: "p-Hpd activity" EXACT [EC:4.1.1.83] synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83] xref: EC:4.1.1.83 xref: KEGG_REACTION:R07312 xref: MetaCyc:4.1.1.83-RXN xref: RHEA:22732 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0043723 name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity namespace: molecular_function alt_id: GO:0017173 def: "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103] synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [MetaCyc:YOL066C-MONOMER] synonym: "DRAP deaminase activity" EXACT [] xref: MetaCyc:RXN-10058 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0043724 name: 2-keto-3-deoxygalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170] synonym: "KDGal aldolase activity" EXACT [] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043725 name: 2-keto-3-deoxygluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170] synonym: "KDG aldolase activity" EXACT [] xref: EC:4.1.2.14 xref: MetaCyc:DHDOGALDOL-RXN xref: RHEA:17089 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043726 name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity namespace: molecular_function alt_id: GO:0019173 def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282] synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah] xref: EC:3.1.3 xref: MetaCyc:RIBOPHOSPHAT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043727 name: 5-amino-4-imidazole carboxylate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835] xref: EC:4.1.1.21 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0043728 name: 2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683] xref: EC:4.1.1 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043729 name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536] is_a: GO:0016829 ! lyase activity [Term] id: GO:0043730 name: 5-ureido-4-imidazole carboxylate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121] is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0043731 name: 6-hydroxynicotinate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] xref: EC:1.14.13.114 xref: MetaCyc:RXN-7573 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043732 name: 6-hydroxynicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2)." [EC:1.17.3.3, RHEA:22808] synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3] synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3] xref: EC:1.17.3.3 xref: KEGG_REACTION:R07221 xref: MetaCyc:RXN-7585 xref: RHEA:22808 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0043733 name: DNA-3-methylbase glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site." [IMG:00576, PMID:10777493, PMID:14517230] synonym: "DNA-3-methyladenine glycosylase III" RELATED [] synonym: "Mag III" NARROW [] synonym: "MagIII" NARROW [] xref: EC:3.2.2 xref: IMG:00576 is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0043734 name: DNA-N1-methyladenine dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, PMID:19786499] synonym: "AlkB" NARROW [] synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW [] xref: EC:1.14.11 xref: Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2" xref: Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3" is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0043736 name: obsolete DNA-3-methyladenine glycosylase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529] comment: This term was made obsolete because it represents an enzyme with four different activities. synonym: "DNA-3-methyladenine glycosylase IV activity" EXACT [] synonym: "Mpg II" NARROW [] synonym: "MpgII" NARROW [] is_obsolete: true consider: GO:0008725 consider: GO:0043916 consider: GO:0052821 consider: GO:0052822 [Term] id: GO:0043737 name: deoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7] synonym: "DNase V activity" EXACT [EC:3.1.21.7] synonym: "endodeoxyribonuclease V" EXACT [] synonym: "endonuclease V activity" BROAD [EC:3.1.21.7] synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7] xref: EC:3.1.21.7 xref: MetaCyc:3.1.21.7-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0043738 name: reduced coenzyme F420 dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420." [MetaCyc:RXN-8106] synonym: "1,5-dihydrocoenzyme F420 dehydrogenase activity" EXACT [CHEBI:15823] synonym: "F420H2 dehydrogenase activity" EXACT [] xref: EC:1.5.98.3 xref: MetaCyc:RXN-8106 xref: RHEA:54752 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043739 name: G/U mismatch-specific uracil-DNA glycosylase activity namespace: molecular_function def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825] synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT [] synonym: "MUG" EXACT [] synonym: "uracil mismatch repair protein" BROAD [] is_a: GO:0004844 ! uracil DNA N-glycosylase activity is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity [Term] id: GO:0043740 name: GTP cyclohydrolase IIa activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate." [EC:3.5.4.29, RHEA:22468] synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29] synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT [] synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29] xref: EC:3.5.4.29 xref: KEGG_REACTION:R07306 xref: MetaCyc:RXN-10055 xref: RHEA:22468 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0043741 name: L-2-aminoadipate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447] xref: MetaCyc:RXN-5181 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0043743 name: LPPG:FO 2-phospho-L-lactate transferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551] xref: EC:2.7.8.28 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043744 name: N2-acetyl-L-aminoadipate kinase activity namespace: molecular_function alt_id: GO:0043868 def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [IMG:01448] synonym: "acetylaminoadipate kinase activity" EXACT [] synonym: "LysZ" RELATED [] synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT [] synonym: "N-acetylaminoadipate kinase activity" EXACT [] xref: MetaCyc:RXN-5182 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0043745 name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449] is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043746 name: N2-acetyl-L-lysine aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450] synonym: "N-acetyl-lysine aminotransferase activity" EXACT [] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043747 name: N2-acetyl-L-lysine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451] synonym: "N-acetyl-lysine deacetylase activity" EXACT [] xref: MetaCyc:RXN-5185 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043748 name: O-succinylbenzoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733] xref: EC:3.5.1 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043749 name: phenol, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277] synonym: "ATP:phenol:water phosphotransferase activity" EXACT [] synonym: "phenol:water dikinase activity" EXACT [] synonym: "phenylphosphate synthase activity" EXACT [] xref: EC:2.7.9 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0043750 name: phosphatidylinositol alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.345] synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [] synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [] synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.345 xref: MetaCyc:2.4.1.57-RXN xref: RHEA:47368 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0043751 name: polyphosphate:AMP phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [PMID:11237733] synonym: "PAP" EXACT [] synonym: "PPT" BROAD [] is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0043752 name: adenosylcobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156] synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT [] xref: EC:2.7.1.156 xref: MetaCyc:2.7.1.156-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043754 name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168] synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] xref: EC:2.3.1.168 xref: MetaCyc:2.3.1.168-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043755 name: alpha-ribazole phosphatase activity namespace: molecular_function alt_id: GO:0019175 def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate." [EC:3.1.3.73, RHEA:24456] synonym: "alpha-ribazole-5'-P phosphatase activity" EXACT [] synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT [] synonym: "CobC" RELATED [] xref: EC:3.1.3.73 xref: KEGG_REACTION:R04594 xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN xref: RHEA:24456 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043756 name: adenosylcobinamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23504] synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90] synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90] synonym: "CbiZ" RELATED [] xref: EC:3.5.1.90 xref: KEGG_REACTION:R05226 xref: MetaCyc:R346-RXN xref: RHEA:23504 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043757 name: adenosylcobinamide-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10] synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT [] synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10] synonym: "CbiB" RELATED [] xref: EC:6.3.1.10 xref: MetaCyc:RXN-6261 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0043758 name: acetate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13] synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13] synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT [] synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13] synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT [] synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13] xref: EC:6.2.1.13 xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN xref: RHEA:15081 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043759 name: branched-chain acyl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425] synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT [] synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT [] is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043760 name: acetyldiaminopimelate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065] synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT [] synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT [] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043761 name: archaetidylserine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT [] synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT [] xref: EC:2.7.8.38 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0043762 name: aryl-CoA synthetase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427] is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043763 name: UTP:glucose-1-phosphate uridylyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl] synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT [] synonym: "UDP-glucose diphosphorylase regulator activity" EXACT [] synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0003983 ! UTP:glucose-1-phosphate uridylyltransferase activity [Term] id: GO:0043764 name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier protein]." [IMG:00545, InterPro:IPR007691] xref: EC:2.3.1.191 xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043765 name: T/G mismatch-specific endonuclease activity namespace: molecular_function def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184] synonym: "DNA mismatch endonuclease" BROAD [] synonym: "V.EcoKDcm" RELATED [] synonym: "very short patch repair protein" RELATED [] synonym: "Vsr mismatch endonuclease" RELATED [] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0043766 name: Sep-tRNA:Cys-tRNA synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate." [EC:2.5.1.73, IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438] synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT [] synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] synonym: "SepCysS" RELATED [] xref: EC:2.5.1.73 xref: MetaCyc:RXN-10719 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0071952 ! conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA [Term] id: GO:0043767 name: pyrrolysyl-tRNA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8] synonym: "PylRS" EXACT [] synonym: "Pyrrolysine-tRNA ligase activity" EXACT [] xref: MetaCyc:6.1.1.26-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0043768 name: S-ribosylhomocysteine lyase activity namespace: molecular_function alt_id: GO:0019138 def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [EC:4.4.1.21, RHEA:17753] synonym: "3.2.1.148" RELATED [] synonym: "LuxS" RELATED [] synonym: "ribosylhomocysteinase activity" EXACT [] synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21] synonym: "S-ribosylhomocysteinase activity" EXACT [] xref: EC:4.4.1.21 xref: KEGG_REACTION:R01291 xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN xref: RHEA:17753 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0043769 name: Tpg-containing telomere binding complex namespace: cellular_component def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591] synonym: "telomere complex" BROAD [] is_a: GO:0000782 ! telomere cap complex [Term] id: GO:0043770 name: demethylmenaquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043771 name: cytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870] is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity relationship: part_of GO:0009224 ! CMP biosynthetic process [Term] id: GO:0043772 name: acyl-phosphate glycerol-3-phosphate acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305] synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043773 name: coenzyme F420-0 gamma-glutamyl ligase activity namespace: molecular_function def: "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [IMG:01552, PMID:17669425] synonym: "F420-0 gamma-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.34 xref: RHEA:30523 is_a: GO:0016881 ! acid-amino acid ligase activity relationship: has_part GO:0052618 ! coenzyme F420-0:L-glutamate ligase activity relationship: has_part GO:0052619 ! coenzyme F420-1:gamma-L-glutamate ligase activity [Term] id: GO:0043774 name: coenzyme F420-2 alpha-glutamyl ligase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553] synonym: "F420-2 alpha-glutamyl ligase activity" EXACT [] xref: EC:6.3.2.32 xref: RHEA:42332 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0043775 name: cobyrinate a,c-diamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814] synonym: "cobyrinate a c diamide synthase activity" EXACT [] synonym: "cobyrinate a c-diamide synthase activity" EXACT [] synonym: "cobyrinate a,c diamide synthase activity" EXACT [] xref: EC:6.3.5.11 xref: RHEA:26289 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0043776 name: cobalt-precorrin-6B C5-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766] synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase activity" EXACT [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: MetaCyc:RXN-8766 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043777 name: cobalt-precorrin-7 C15-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767] synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT [] synonym: "precorrin-6 methyltransferase" BROAD [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: MetaCyc:RXN-8767 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043778 name: cobalt-precorrin-8 methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768] synonym: "cobalt-precorrin 8 methylmutase activity" EXACT [] synonym: "cobalt-precorrin 8X methylmutase activity" EXACT [] synonym: "cobalt-precorrin-8X methylmutase activity" EXACT [] xref: EC:5.4.99.60 xref: MetaCyc:RXN-8768 xref: RHEA:16209 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0043779 name: cobalt-precorrin-5A acetaldehyde-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763] synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] xref: MetaCyc:RXN-8763 is_a: GO:0016829 ! lyase activity [Term] id: GO:0043780 name: cobalt-precorrin-5B C1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764] synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8764 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043781 name: cobalt-factor II C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812] synonym: "CbiL" NARROW [] synonym: "cobalt-factor II C20 methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151] synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151] xref: EC:2.1.1.151 xref: MetaCyc:RXN-8760 xref: RHEA:17997 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043782 name: cobalt-precorrin-3 C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761] synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT [] synonym: "cobalt-precorrin-3 methylase" BROAD [] synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8761 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043783 name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8] xref: EC:1.16.8 is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0043784 name: cob(II)yrinic acid a,c-diamide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2)." [EC:1.16.8.1, RHEA:24300] synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT [] xref: EC:1.16.8.1 xref: KEGG_REACTION:R05218 xref: MetaCyc:R343-RXN xref: RHEA:24300 is_a: GO:0043783 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor [Term] id: GO:0043785 name: cinnamoyl-CoA:phenyllactate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15601] synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT [] synonym: "FldA" RELATED [] xref: EC:2.8.3.17 xref: KEGG_REACTION:R07796 xref: MetaCyc:2.8.3.17-RXN xref: RHEA:15601 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043786 name: cinnamate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007] is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043791 name: dimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228] comment: This function is the first step in the pathway of methanogenesis from dimethylamine. synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "DMA methyltransferase 1" EXACT [] synonym: "DMAMT 1" EXACT [] synonym: "MT1" BROAD [] synonym: "mtbB1" RELATED [] xref: MetaCyc:RXN-8100 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043792 name: enamidase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+)." [EC:3.5.2.18, RHEA:17209] synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT [] xref: EC:3.5.2.18 xref: KEGG_REACTION:R07984 xref: MetaCyc:3.5.2.18-RXN xref: RHEA:17209 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043793 name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate." [GOC:jl, IMG:01544, PMID:12142414] synonym: "beta-RFAP synthase activity" EXACT [] xref: MetaCyc:RXN-8124 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0043794 name: formate dehydrogenase (coenzyme F420) activity namespace: molecular_function def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411] synonym: "formate dehydrogenase (F420) activity" EXACT [] xref: EC:1.2.99 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0043795 name: glyceraldehyde oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506] is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0043796 name: glyceraldehyde dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [EC:1.2.1.89, IMG:01555] xref: EC:1.2.1.89 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043797 name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6] synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT [] synonym: "GAPOR" RELATED [] synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6] synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6] xref: EC:1.2.7.6 xref: MetaCyc:1.2.7.6-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043798 name: glycerate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719] synonym: "D-glycerate 2-kinase activity" EXACT [] synonym: "glycerate kinase" BROAD [] xref: EC:2.7.1 xref: MetaCyc:GKI-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0043799 name: glycine oxidase activity namespace: molecular_function def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19] synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT [] xref: EC:1.4.3.19 xref: MetaCyc:1.4.3.19-RXN xref: MetaCyc:RXN-8672 xref: MetaCyc:RXN-8673 xref: MetaCyc:RXN-8674 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0043800 name: hexulose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, MetaCyc:R12-RXN, PMID:11839305] synonym: "HUMPI" EXACT [] xref: EC:5.3.1.27 xref: MetaCyc:R12-RXN xref: RHEA:25900 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0043801 name: hexulose-6-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, PMID:16075199] xref: EC:4.1.2.43 xref: MetaCyc:R10-RXN xref: RHEA:25201 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043802 name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12544] synonym: "CobB" RELATED [] synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT [] xref: EC:6.3.5.9 xref: KEGG_REACTION:R05224 xref: MetaCyc:R341-RXN xref: RHEA:12544 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0043803 name: hydroxyneurosporene-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043804 name: imidazolone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122] is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043805 name: indolepyruvate ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8] synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8] synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8] synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8] synonym: "IOR" RELATED [] xref: EC:1.2.7.8 xref: MetaCyc:1.2.7.8-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043806 name: keto acid formate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, MetaCyc:KETOBUTFORMLY-RXN] synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "keto-acid formate lyase activity" EXACT [] synonym: "keto-acid formate-lyase activity" EXACT [] xref: EC:2.3.1 xref: MetaCyc:KETOBUTFORMLY-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043807 name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7] synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7] synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT [] synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7] synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "VOR" RELATED [] xref: EC:1.2.7.7 xref: MetaCyc:1.2.7.7-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043808 name: lyso-ornithine lipid acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [IMG:02097, PMID:15341653] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0043810 name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]." [IMG:02096] synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT [] is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0043811 name: phosphate:acyl-[acyl carrier protein] acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [IMG:01871] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043812 name: phosphatidylinositol-4-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360] synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] xref: EC:3.1.3 is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity [Term] id: GO:0043813 name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, PMID:10806194, PMID:16607019] synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] xref: EC:3.1.3 xref: Reactome:R-HSA-1675836 "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane" xref: Reactome:R-HSA-1676005 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane" xref: Reactome:R-HSA-1676020 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane" xref: Reactome:R-HSA-1676174 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane" is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity relationship: part_of GO:0036092 ! phosphatidylinositol-3-phosphate biosynthetic process [Term] id: GO:0043814 name: phospholactate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [IMG:01547] xref: EC:2.7.7 xref: MetaCyc:RXN-8077 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0043815 name: phosphoribosylglycinamide formyltransferase 2 activity namespace: molecular_function def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [EC:2.1.2.2, IMG:01297, PMID:8117714] synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT [] synonym: "formate-dependent GAR transformylase activity" EXACT [] synonym: "GAR transformylase 2" RELATED [] synonym: "GART 2" RELATED [] xref: MetaCyc:GARTRANSFORMYL2-RXN is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0043816 name: phosphoserine-tRNA(Cys) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438] synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT [] synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT [] synonym: "phosphoserine-tRNACys ligase activity" EXACT [] synonym: "SepRS" RELATED [] is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0043817 name: phosphosulfolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22784] synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19] synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT [] synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19] synonym: "PSL synthase activity" EXACT [EC:4.4.1.19] xref: EC:4.4.1.19 xref: KEGG_REACTION:R07476 xref: MetaCyc:4.4.1.19-RXN xref: MetaCyc:R228-RXN xref: RHEA:22784 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0043818 name: precorrin-3B synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B." [EC:1.14.13.83, RHEA:17293] synonym: "CobG" RELATED [] synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT [] synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83] xref: EC:1.14.13.83 xref: KEGG_REACTION:R05217 xref: MetaCyc:R321-RXN xref: RHEA:17293 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0043819 name: precorrin-6A synthase (deacetylating) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X." [EC:2.1.1.152, RHEA:18261] synonym: "CobF" RELATED [] synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152] synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT [] xref: EC:2.1.1.152 xref: KEGG_REACTION:R05219 xref: MetaCyc:R322-RXN xref: RHEA:18261 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043820 name: propionyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323] xref: EC:1.3.99 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0043821 name: propionyl-CoA:succinate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268] synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] xref: MetaCyc:RXN0-268 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043822 name: ribonuclease M5 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522] synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8] synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT [] synonym: "RNase M5 activity" EXACT [EC:3.1.26.8] xref: EC:3.1.26.8 xref: MetaCyc:3.1.26.8-RXN is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0043823 name: spheroidene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [IMG:01761, MetaCyc:RXN-10670, PMID:16086104, PMID:16158287] xref: EC:1.14.15.9 xref: MetaCyc:RXN-10670 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0043824 name: succinylglutamate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH." [EC:1.2.1.71, RHEA:10812] synonym: "AruD" RELATED [] synonym: "AstD" RELATED [] synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71] synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] synonym: "SGSD" RELATED [] synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT [] synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] xref: EC:1.2.1.71 xref: KEGG_REACTION:R05049 xref: MetaCyc:SUCCGLUALDDEHYD-RXN xref: RHEA:10812 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043825 name: succinylornithine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16953] synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "AstC" RELATED [] synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81] synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [] synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT [] synonym: "SOAT" RELATED [] synonym: "succinyl ornithine transaminase activity" EXACT [] synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81] xref: EC:2.6.1.81 xref: KEGG_REACTION:R04217 xref: MetaCyc:SUCCORNTRANSAM-RXN xref: RHEA:16953 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043826 name: sulfur oxygenase reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063] synonym: "SOR" RELATED [] synonym: "sulphur oxygenase reductase activity" EXACT [] xref: EC:1.13.11.55 xref: MetaCyc:RXN-8226 xref: RHEA:13957 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043827 name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity namespace: molecular_function def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239] synonym: "TrmI" RELATED [] synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT [] synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT [] synonym: "tRNA (m1A) MTase" BROAD [] is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity [Term] id: GO:0043828 name: tRNA 2-selenouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281] synonym: "B0503" RELATED [] synonym: "SelU" RELATED [] synonym: "YbbB" RELATED [] xref: MetaCyc:RXN0-2281 is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0043829 name: tRNA-specific adenosine-37 deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, PMID:8915538, PMID:9707437] synonym: "TAD1" RELATED [] synonym: "tRNA(Ala)-A37 deaminase activity" EXACT [] synonym: "tRNA-specific adenosine deaminase 1" EXACT [] is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity [Term] id: GO:0043830 name: thiol-driven fumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466] xref: EC:1.3.99 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0043831 name: thiosulfate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [EC:1.8.5.2, RHEA:10936] synonym: "DoxA" RELATED [] synonym: "DoxD" RELATED [] synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2] synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT [] synonym: "thiosulphate:quinone oxidoreductase activity" EXACT [] synonym: "TQO" RELATED [] xref: EC:1.8.5.2 xref: KEGG_REACTION:R07177 xref: MetaCyc:1.8.5.2-RXN xref: RHEA:10936 is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0043833 name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a methylated methylamine corrinoid protein + coenzyme M = a methylamine corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099] comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase activity" EXACT [] synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED [] synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] synonym: "MT2" BROAD [] synonym: "MT2-A" RELATED [] synonym: "MtbA" RELATED [] synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] xref: MetaCyc:RXN-8099 xref: MetaCyc:RXN-8101 xref: MetaCyc:RXN-8103 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043834 name: trimethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102] comment: This function is the first step in the pathway of methanogenesis from trimethylamine. synonym: "MT1" BROAD [] synonym: "mttB1" RELATED [] synonym: "TMA methyltransferase 1" EXACT [] synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8102 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043835 name: obsolete uracil/thymine dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821] comment: This term was made obsolete because it represents two separate molecular functions. synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4] synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4] synonym: "uracil/thymine dehydrogenase activity" EXACT [] synonym: "uracil:acceptor oxidoreductase activity" NARROW [] xref: EC:1.17.99.4 is_obsolete: true consider: GO:0050383 consider: GO:0052620 [Term] id: GO:0043836 name: xanthine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN] synonym: "xanthinase activity" EXACT [] xref: MetaCyc:R127-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0043837 name: valine dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [IMG:00766, PMID:10612726, PMID:2803248] synonym: "ValDH" RELATED [] xref: EC:1.4.1.23 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0043838 name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity namespace: molecular_function def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227] comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. synonym: "EptB" RELATED [] synonym: "phosphoethanolamine transferase" BROAD [] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0043839 name: lipid A phosphate methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [IMG:02094, PMID:15994324] synonym: "lipid A 1-phosphomethyltransferase activity" EXACT [] synonym: "lipid A methyltransferase" BROAD [] synonym: "lipid A phosphomethyltransferase activity" EXACT [] synonym: "LmtA" RELATED [] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0043840 name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965] synonym: "BCAT" RELATED [] synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] synonym: "branched-chain amino acid aminotransferase" BROAD [] synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] xref: MetaCyc:RXN-7708 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043841 name: (S)-lactate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:01546, PMID:11535063] synonym: "lactate 2-kinase activity" EXACT [] xref: IMG:01546 xref: MetaCyc:RXN-8076 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043842 name: Kdo transferase activity namespace: molecular_function def: "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [EC:2.4.99.12, EC:2.4.99.13, EC:2.4.99.14, EC:2.4.99.15, IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966] synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT [] synonym: "kdtA" RELATED [] synonym: "WaaA" RELATED [] xref: MetaCyc:KDOTRANS-RXN xref: MetaCyc:KDOTRANS2-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0043843 name: ADP-specific glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468] synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147] synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147] xref: EC:2.7.1.147 xref: Reactome:R-HSA-5696021 "ADPGK:Mg2+ phosphorylates Glc to G6P" xref: RHEA:11460 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043844 name: ADP-specific phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469] synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146] synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146] synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146] xref: EC:2.7.1.146 xref: RHEA:20105 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043845 name: DNA polymerase III, proofreading complex namespace: cellular_component def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [IMG:01721, PMID:16973612, Wikipedia:Pol_III] synonym: "DNA polymerase III, proof-reading complex" EXACT [] synonym: "DNA polymerase III, proof-reading subcomplex" EXACT [] synonym: "DNA polymerase III, proofreading subcomplex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0044776 ! DNA polymerase III, core complex [Term] id: GO:0043846 name: DNA polymerase III, clamp loader complex namespace: cellular_component def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977] synonym: "clamp loader complex" BROAD [] synonym: "DNA polymerase III, DnaX complex" EXACT [] synonym: "DNA polymerase III, DnaX subcomplex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0009360 ! DNA polymerase III complex [Term] id: GO:0043847 name: DNA polymerase III, clamp loader chi/psi subcomplex namespace: cellular_component def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977] synonym: "DNA polymerase III, DnaX complex, chi/psi subcomplex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043846 ! DNA polymerase III, clamp loader complex [Term] id: GO:0043848 name: excinuclease cho activity namespace: molecular_function def: "Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [IMG:00499, PMID:11818552] comment: Note that this function occurs as part of nucleotide excision repair (NER). synonym: "cho" RELATED [] synonym: "endonuclease cho" EXACT [] synonym: "uvrc homolog protein" RELATED [] is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base [Term] id: GO:0043849 name: Ras palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, PMID:16000296] synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED [] synonym: "ERF2" RELATED [] synonym: "palmitoyltransferase ERF2" RELATED [] synonym: "Ras protein acyltransferase activity" EXACT [] is_a: GO:0019706 ! protein-cysteine S-palmitoyltransferase activity [Term] id: GO:0043850 name: RecFOR complex namespace: cellular_component def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0043851 name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a methylated methanol corrinoid protein + coenzyme M = a methanol corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096] comment: This function is the second step in the pathway of methanogenesis from methanol. synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT [] synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT [] synonym: "methyltransferase 2" BROAD [] synonym: "MT2" BROAD [] synonym: "MtaA" RELATED [] synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT [] synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8096 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043852 name: monomethylamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [IMG:01319, MetaCyc:RXN-8098] comment: This function is the first step in the pathway of methanogenesis from monomethylamine. synonym: "MMAMT" RELATED [] synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "MtmB" RELATED [] xref: MetaCyc:RXN-8098 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0043853 name: methanol-CoM methyltransferase complex namespace: cellular_component def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780] synonym: "methanol-coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: coenzyme M methyltransferase complex" EXACT [] synonym: "methanol: CoM methyltransferase complex" EXACT [] synonym: "methanol:coenzyme M methyltransferase complex" EXACT [] synonym: "methanol:CoM methyltransferase complex" EXACT [] xref: MetaCyc:CPLX-421 is_a: GO:0034708 ! methyltransferase complex [Term] id: GO:0043854 name: cyclic nucleotide-gated mechanosensitive ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416] synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT [] synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT [] synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED [] synonym: "MscS" RELATED [] synonym: "small conductance mechanosensitive ion channel" EXACT [] is_a: GO:0008381 ! mechanosensitive ion channel activity [Term] id: GO:0043855 name: cyclic nucleotide-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl] synonym: "cyclic nucleotide activated ion channel activity" EXACT [] synonym: "cyclic nucleotide gated ion channel activity" EXACT [] synonym: "cyclic nucleotide-activated ion channel activity" EXACT [] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0043856 name: anti-sigma factor antagonist activity namespace: molecular_function def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799] synonym: "anti-anti-sigma factor activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-templated [Term] id: GO:0043857 name: N-acetylornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate." [EC:2.1.3.9, RHEA:18609] synonym: "acetylornithine transcarbamylase activity" EXACT [] synonym: "AOTC" RELATED [] synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] synonym: "N-acetylornithine transcarbamylase activity" EXACT [] xref: EC:2.1.3.9 xref: KEGG_REACTION:R07245 xref: MetaCyc:2.1.3.9-RXN xref: RHEA:18609 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0043858 name: arginine:ornithine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979] synonym: "ArcD" RELATED [] synonym: "arginine-ornithine antiporter activity" EXACT [] synonym: "arginine/ornithine antiporter activity" EXACT [] is_a: GO:0015181 ! arginine transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0043859 name: obsolete cyanophycinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200] comment: This term was made obsolete because it represents a gene product. synonym: "cyanophycinase activity" EXACT [] xref: EC:3 is_obsolete: true replaced_by: GO:0008236 [Term] id: GO:0043860 name: cyanophycin synthetase activity namespace: molecular_function def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl] synonym: "cphA" RELATED [] xref: EC:6.3.1 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0043861 name: agmatine:putrescine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272] synonym: "agmatine-putrescine antiporter activity" EXACT [] synonym: "agmatine/putrescine antiporter activity" EXACT [] is_a: GO:0015489 ! putrescine transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0043862 name: arginine:agmatine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215] synonym: "AdiC" RELATED [] synonym: "arginine-agmatine antiporter activity" EXACT [] synonym: "arginine-agmatine exchange transporter activity" EXACT [] synonym: "arginine/agmatine antiporter activity" EXACT [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0043863 name: 4-hydroxy-2-ketopimelate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN] synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT [] synonym: "HHED aldolase activity" EXACT [] synonym: "HpaI" RELATED [] synonym: "HpcH" RELATED [] xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043864 name: indoleacetamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, MetaCyc:RXNN-404] synonym: "IaaH" RELATED [] synonym: "IAH" EXACT [] synonym: "indole acetamide hydrolase activity" EXACT [] synonym: "indole-3-acetamide hydrolase activity" EXACT [] synonym: "Tms2" RELATED [] xref: EC:3.5.1.4 xref: MetaCyc:G-5841 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043865 name: methionine transmembrane transporter activity namespace: molecular_function alt_id: GO:1990240 def: "Enables the transfer of methionine from one side of a membrane to the other." [GOC:jl] synonym: "methionine importer" RELATED [] synonym: "methionine importer activity" NARROW [] synonym: "methionine importing activity" NARROW [] synonym: "methionine-importing activity" NARROW [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity relationship: part_of GO:0015821 ! methionine transport created_by: pr creation_date: 2013-11-15T10:35:04Z [Term] id: GO:0043866 name: adenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10] synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [] synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10] synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT [] xref: EC:1.8.4.10 xref: RHEA:21976 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0043867 name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953] synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT [] synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT [] synonym: "TgtA" RELATED [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0043869 name: alpha-aminoadipate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802] synonym: "lysine biosynthesis protein" RELATED [] synonym: "LysX" RELATED [] synonym: "RimK" RELATED [] xref: MetaCyc:RXN-5181 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0043870 name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183] comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. synonym: "AGPR" RELATED [] synonym: "ArgC" RELATED [] synonym: "LysY" RELATED [] synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] synonym: "NAGSA dehydrogenase activity" BROAD [] xref: MetaCyc:RXN-5183 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043871 name: delta1-piperideine-6-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033] comment: This function is part of the pipecolate pathway of lysine catabolism. synonym: "AmaB" RELATED [] synonym: "PIPOX" RELATED [] xref: MetaCyc:RXN-8162 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043872 name: lysine:cadaverine antiporter activity namespace: molecular_function alt_id: GO:0015490 alt_id: GO:0015497 def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2] synonym: "cadaverine transmembrane transporter activity" NARROW [] synonym: "cadaverine:lysine antiporter activity" EXACT [] synonym: "lysine-cadaverine antiporter activity" EXACT [] synonym: "lysine/cadaverine antiporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0043873 name: pyruvate-flavodoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705] synonym: "NifJ" RELATED [] synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] xref: MetaCyc:PYFLAVOXRE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043874 name: acireductone synthase activity namespace: molecular_function def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77] comment: This function is involved in the process of methionine salvage. synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77] synonym: "E-1" RELATED [] synonym: "E-1 enolase-phosphatase" BROAD [] xref: EC:3.1.3.77 xref: MetaCyc:3.1.3.77-RXN xref: Reactome:R-HSA-1237129 "Acireductone is created" xref: RHEA:24650 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0043875 name: 2-ketobutyrate formate-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901] comment: This function is part of an anaerobic pathway for the catabolism of L-threonine. synonym: "keto-acid formate acetyltransferase" BROAD [] synonym: "KFL" EXACT [] synonym: "TdcE" RELATED [] xref: MetaCyc:KETOBUTFORMLY-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043876 name: D-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221] synonym: "D-allo-TA" EXACT [] synonym: "D-allo-threonine aldolase activity" EXACT [] synonym: "D-TA" EXACT [] synonym: "DtaAS" RELATED [] synonym: "low-specificity D-threonine aldolase" NARROW [] xref: EC:4.1.2.42 xref: MetaCyc:4.1.2.42-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0043877 name: galactosamine-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310] comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. synonym: "AgaI" RELATED [] synonym: "galactosamine-6-phosphate deaminase activity" EXACT [] is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0043878 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT [] synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] xref: EC:1.2.1.3 xref: MetaCyc:RXN-3443 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043879 name: glycolate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [GOC:jl] synonym: "glcA" RELATED [] synonym: "glycolate permease" RELATED [] synonym: "glycolic acid transmembrane transporter activity" EXACT [] synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity relationship: part_of GO:0097339 ! glycolate transmembrane transport [Term] id: GO:0043880 name: crotonyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [InterPro:IPR010085, PMID:11162231] synonym: "CCR" EXACT [] synonym: "crotonyl-coenzyme A reductase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043881 name: mesaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937] comment: This function is part of an alternate glyoxylate cycle for acetate assimilation. synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT [] synonym: "mch" RELATED [] synonym: "mesaconyl-coenzyme A hydratase activity" EXACT [] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043882 name: malate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309] synonym: "malate Na(+) symporter activity" EXACT [] synonym: "malate-sodium symporter activity" EXACT [] synonym: "malate/sodium cotransporter activity" BROAD [] synonym: "malate/sodium symporter activity" EXACT [] synonym: "malate:Na+ symporter activity" EXACT [] synonym: "malate:sodium cotransporter activity" BROAD [] synonym: "Na(+)-malate symporter activity" EXACT [] synonym: "Na+:malate symporter activity" EXACT [] synonym: "sodium-dependent malate transporter" BROAD [] synonym: "sodium/malate symporter activity" EXACT [] synonym: "sodium:malate symporter activity" EXACT [] is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0043883 name: malolactic enzyme activity namespace: molecular_function def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053] comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria. synonym: "MleS" RELATED [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043884 name: CO-methylating acetyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656] synonym: "acetyl-CoA synthase activity" BROAD [] synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT [] synonym: "ACS" RELATED [EC:2.3.1.169] synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] xref: EC:2.3.1.169 xref: MetaCyc:ACETYLSYNCLTH-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0043885 name: carbon-monoxide dehydrogenase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4] synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT [] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4] synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT [] synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT [] synonym: "CO dehydrogenase activity" EXACT [] synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT [] synonym: "CO-dehydrogenase activity" EXACT [] synonym: "CODH" RELATED [] xref: EC:1.2.7.4 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0043886 name: structural constituent of carboxysome namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0031470 ! carboxysome relationship: occurs_in GO:0031470 ! carboxysome [Term] id: GO:0043887 name: melibiose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646] synonym: "MelB" RELATED [] synonym: "melibiose carrier protein" RELATED [] synonym: "melibiose permease" BROAD [] synonym: "melibiose-Na+ symporter activity" EXACT [] synonym: "melibiose-sodium symporter activity" EXACT [] synonym: "melibiose/Na+ symporter activity" EXACT [] synonym: "melibiose/sodium symporter activity" EXACT [] synonym: "melibiose:Na+ symporter activity" EXACT [] synonym: "Na+ (Li+)/melibiose symporter activity" EXACT [] synonym: "Na+-melibiose symporter activity" EXACT [] synonym: "Na+/melibiose symporter activity" EXACT [] synonym: "Na+:melibiose symporter activity" EXACT [] synonym: "sodium-melibiose symporter activity" EXACT [] synonym: "sodium/melibiose symporter activity" EXACT [] synonym: "sodium:melibiose symporter activity" EXACT [] synonym: "thiomethylgalactoside permease II" RELATED [] is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:0015487 ! melibiose:cation symporter activity [Term] id: GO:0043888 name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity namespace: molecular_function def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480] comment: This function is involved in archaeal lipid synthesis. synonym: "2,3-dGGGPS" EXACT [] synonym: "DGGGP synthase activity" EXACT [] synonym: "DGGGPS" EXACT [] synonym: "UbiA" RELATED [] xref: EC:2.5.1 is_a: GO:0002094 ! polyprenyltransferase activity is_a: GO:0004337 ! geranyltranstransferase activity [Term] id: GO:0043889 name: (S)-3-O-geranylgeranylglyceryl phosphate synthase activity namespace: molecular_function def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023] comment: This function is involved in archaeal lipid synthesis. synonym: "(S)-3-O-geranylgeranylglycerylphosphate synthase activity" EXACT [] synonym: "(S)-GGGP synthase activity" EXACT [] synonym: "GGGP synthase activity" EXACT [] synonym: "GGGPS" EXACT [] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0043890 name: N-acetylgalactosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4] synonym: "acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "chondroitin sulfatase" BROAD [] synonym: "chondroitinase" BROAD [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4] synonym: "galactose-6-sulfate sulfatase activity" EXACT [] synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [] synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT [] synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT [] xref: EC:3.1.6.4 xref: MetaCyc:3.1.6.4-RXN xref: Reactome:R-HSA-1630304 "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate" xref: Reactome:R-HSA-2263490 "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0043891 name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59] synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT [] synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59] synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT [] synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59] xref: EC:1.2.1.59 xref: MetaCyc:GAPDHSYNEC-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0043892 name: methylglyoxal reductase (NADPH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283] synonym: "Gre2" RELATED [] synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT [] synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283] xref: EC:1.1.1.283 xref: MetaCyc:1.1.1.283-RXN xref: MetaCyc:RXN-8636 xref: RHEA:21748 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0043893 name: acetate:cation symporter activity namespace: molecular_function def: "Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl, PMID:14563880] synonym: "acetate permease" BROAD [] synonym: "acetate-cation symporter activity" EXACT [] synonym: "acetate/cation symporter activity" EXACT [] synonym: "ActP" RELATED [] synonym: "cation-acetate symporter activity" EXACT [] synonym: "cation/acetate symporter activity" EXACT [] synonym: "cation:acetate symporter activity" EXACT [] is_a: GO:0015123 ! acetate transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0043894 name: acetyl-CoA synthetase acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963] synonym: "Pat" RELATED [] synonym: "Pat enzyme" EXACT [] synonym: "protein acetyltransferase activity" BROAD [] is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0043895 name: cyclomaltodextrin glucanotransferase activity namespace: molecular_function def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19] synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT [] synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED [] synonym: "alpha-cyclodextrin glucanotransferase" RELATED [] synonym: "alpha-cyclodextrin glycosyltransferase" RELATED [] synonym: "Bacillus macerans amylase" RELATED [] synonym: "beta-cyclodextrin glucanotransferase" RELATED [] synonym: "beta-cyclodextrin glycosyltransferase" RELATED [] synonym: "BMA" RELATED [] synonym: "CGTase" RELATED [] synonym: "cyclodextrin glucanotransferase" BROAD [] synonym: "cyclodextrin glycosyltransferase" RELATED [] synonym: "cyclomaltodextrin glucotransferase" RELATED [] synonym: "cyclomaltodextrin glycosyltransferase" RELATED [] synonym: "gamma-cyclodextrin glycosyltransferase" RELATED [] synonym: "konchizaimu" RELATED [] synonym: "neutral-cyclodextrin glycosyltransferase" RELATED [] xref: EC:2.4.1.19 xref: MetaCyc:2.4.1.19-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0043896 name: glucan 1,6-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70] synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70] synonym: "exo-1,6-beta-glucosidase" RELATED [] synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70] synonym: "glucan-1,6-alpha-glucosidase activity" EXACT [] synonym: "glucodextranase activity" EXACT [EC:3.2.1.70] synonym: "glucodextrinase" BROAD [] xref: EC:3.2.1.70 xref: MetaCyc:3.2.1.70-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0043897 name: glucan 1,4-alpha-maltohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133] synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT [] synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT [] synonym: "maltogenic alpha-amylase activity" EXACT [] xref: EC:3.2.1.133 xref: MetaCyc:3.2.1.133-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0043898 name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866] synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT [] synonym: "BphC" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0043899 name: phosphoserine:homoserine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121] synonym: "thrH" RELATED [] xref: IMG:02616 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0043900 name: regulation of multi-organism process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051704 ! multi-organism process relationship: regulates GO:0051704 ! multi-organism process [Term] id: GO:0043901 name: negative regulation of multi-organism process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051704 ! multi-organism process relationship: negatively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043902 name: positive regulation of multi-organism process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051704 ! multi-organism process relationship: positively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043903 name: regulation of symbiosis, encompassing mutualism through parasitism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044403 ! symbiotic process relationship: regulates GO:0044403 ! symbiotic process [Term] id: GO:0043904 name: isochorismate pyruvate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620] synonym: "IPL" EXACT [] synonym: "isochorismate-pyruvate lyase activity" EXACT [] xref: EC:4.2.99.21 xref: IMG:02661 xref: MetaCyc:RXN-1981 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0043905 name: Ser-tRNA(Thr) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874] synonym: "Ser-tRNAThr hydrolase activity" EXACT [] xref: EC:3.1.1 xref: IMG:02667 is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0043906 name: Ala-tRNA(Pro) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147] synonym: "Ala-tRNAPro hydrolase activity" EXACT [] xref: EC:3.1.1 xref: IMG:02668 is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0043907 name: Cys-tRNA(Pro) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196] synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT [] synonym: "Cys-tRNAPro hydrolase activity" EXACT [] xref: EC:3.1.1 xref: IMG:02669 is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0043908 name: Ser(Gly)-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147] synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT [] xref: EC:3.1.1 xref: IMG:02670 is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0043909 name: N-acetylcitrulline deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290] synonym: "acetylcitrulline deacetylase activity" EXACT [] synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT [] xref: EC:3.5.1.B4 xref: IMG:02799 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0043910 name: ATP:coenzyme F420 adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate." [GOC:jl, IMG:02803, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473] synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT [] synonym: "coenzyme F390-A synthetase activity" EXACT [] xref: EC:2.7.7 xref: IMG:02803 xref: MetaCyc:RXN-9385 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0043911 name: D-lysine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313] synonym: "D-lysine aminotransferase activity" EXACT [] xref: IMG:02956 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0043912 name: D-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide." [GOC:jl, IMG:02957, PMID:17259313] xref: EC:1.4.3 xref: IMG:02957 is_a: GO:0003884 ! D-amino-acid oxidase activity [Term] id: GO:0043913 name: chromosome segregation-directing complex namespace: cellular_component def: "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918] synonym: "chromosome segregation directing complex" EXACT [] synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT [] synonym: "MreBCD complex" NARROW [] xref: IMG:02994 is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0043914 name: NADPH:sulfur oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625] synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT [] synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT [] synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT [] synonym: "NADPH:sulphur oxidoreductase activity" EXACT [] synonym: "NSR" EXACT [] xref: EC:1.8.1.18 xref: IMG:03008 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0043915 name: L-seryl-tRNA(Sec) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, PMID:16201757] synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT [] xref: IMG:03019 xref: MetaCyc:RXN-10038 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0043916 name: DNA-7-methylguanine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998] xref: EC:3.2.2.21 xref: IMG:03021 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0043917 name: ribose 1,5-bisphosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024] synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT [] xref: EC:5.3.1.29 xref: IMG:03024 xref: MetaCyc:RXN-8801 xref: RHEA:32243 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0043918 name: cadaverine aminopropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282] synonym: "cadaverine aminopropyl transferase activity" EXACT [] xref: EC:2.5.1.104 xref: IMG:00522 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0043919 name: agmatine aminopropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049] synonym: "agmatine aminopropyl transferase activity" EXACT [] xref: EC:2.5.1.104 xref: IMG:03077 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0043920 name: aminopropylagmatine ureohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049] xref: IMG:03079 xref: RHEA:35828 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0043921 name: modulation by host of viral transcription namespace: biological_process def: "Any process in which a host organism modulates the frequency, rate or extent of viral transcription." [GOC:jl] synonym: "regulation by host of viral transcription" EXACT [] synonym: "regulation of viral transcription by host" EXACT [] is_a: GO:0043922 ! negative regulation by host of viral transcription is_a: GO:0044793 ! negative regulation by host of viral process intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: negatively_regulates GO:0019083 ! viral transcription [Term] id: GO:0043922 name: negative regulation by host of viral transcription namespace: biological_process def: "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl] synonym: "negative regulation of viral transcription by host" EXACT [] is_a: GO:0032897 ! negative regulation of viral transcription is_a: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: negatively_regulates GO:0019083 ! viral transcription [Term] id: GO:0043923 name: positive regulation by host of viral transcription namespace: biological_process def: "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] synonym: "positive regulation of viral transcription by host" EXACT [] is_a: GO:0050434 ! positive regulation of viral transcription is_a: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: positively_regulates GO:0019083 ! viral transcription [Term] id: GO:0043924 name: suramin binding namespace: molecular_function def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin] synonym: "Germanin binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0043927 name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [Term] id: GO:0043928 name: exonucleolytic catabolism of deadenylated mRNA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0043929 name: primary ovarian follicle growth involved in double layer follicle stage namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo] synonym: "primary ovarian follicle growth during double layer follicle stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001545 ! primary ovarian follicle growth intersection_of: GO:0001545 ! primary ovarian follicle growth intersection_of: part_of GO:0048161 ! double layer follicle stage relationship: part_of GO:0048161 ! double layer follicle stage [Term] id: GO:0043930 name: primary ovarian follicle growth involved in primary follicle stage namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo] synonym: "primary ovarian follicle growth during primary follicle stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001545 ! primary ovarian follicle growth intersection_of: GO:0001545 ! primary ovarian follicle growth intersection_of: part_of GO:0048160 ! primary follicle stage relationship: part_of GO:0048160 ! primary follicle stage [Term] id: GO:0043931 name: ossification involved in bone maturation namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034] synonym: "ossification involved in skeletal development" EXACT [GOC:dph] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: part_of GO:0070977 ! bone maturation relationship: part_of GO:0070977 ! bone maturation [Term] id: GO:0043932 name: ossification involved in bone remodeling namespace: biological_process def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo] synonym: "ossification involved in bone remodelling" RELATED [] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: part_of GO:0046849 ! bone remodeling relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0043933 name: protein-containing complex subunit organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 alt_id: GO:0071822 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] is_a: GO:0016043 ! cellular component organization created_by: midori creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0032502 ! developmental process [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0034293 ! sexual sporulation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0043936 name: asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di] synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0043937 name: regulation of sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043934 ! sporulation relationship: regulates GO:0043934 ! sporulation [Term] id: GO:0043938 name: positive regulation of sporulation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043934 ! sporulation relationship: positively_regulates GO:0043934 ! sporulation [Term] id: GO:0043939 name: negative regulation of sporulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043934 ! sporulation relationship: negatively_regulates GO:0043934 ! sporulation [Term] id: GO:0043940 name: regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0034306 ! regulation of sexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043941 name: positive regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043942 name: negative regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0051447 ! negative regulation of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043943 name: regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043944 name: negative regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:1903665 ! negative regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043945 name: positive regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore is_a: GO:1903666 ! positive regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043946 name: positive regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "activation of enzyme activity in other organism" NARROW [] synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0043947 name: positive regulation by host of symbiont catalytic activity namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by host of symbiont enzyme activity" NARROW [] synonym: "activation of symbiont enzyme activity" NARROW [] synonym: "positive regulation by host of symbiont enzyme activity" EXACT [] synonym: "up regulation by host of symbiont enzyme activity" EXACT [] synonym: "up-regulation by host of symbiont enzyme activity" EXACT [] synonym: "upregulation by host of symbiont enzyme activity" EXACT [] is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052422 ! modulation by host of symbiont catalytic activity [Term] id: GO:0043948 name: induction by symbiont of host catalytic activity namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host enzyme activity" NARROW [] synonym: "activation of host enzyme activity" NARROW [] synonym: "positive regulation by symbiont of host catalytic activity" EXACT [] synonym: "positive regulation by symbiont of host enzyme activity" EXACT [] synonym: "up regulation by symbiont of host enzyme activity" EXACT [] synonym: "up-regulation by symbiont of host enzyme activity" EXACT [] synonym: "upregulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052148 ! modulation by symbiont of host catalytic activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043949 name: regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "regulation of cAMP-mediated signalling" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019933 ! cAMP-mediated signaling relationship: regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043950 name: positive regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "positive regulation of cAMP-mediated signalling" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019933 ! cAMP-mediated signaling relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043951 name: negative regulation of cAMP-mediated signaling namespace: biological_process def: "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] synonym: "negative regulation of cAMP-mediated signalling" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019933 ! cAMP-mediated signaling relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0043952 name: protein transport by the Sec complex namespace: biological_process def: "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'protein secretion by the type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. synonym: "protein secretion by the Sec complex" NARROW [] synonym: "protein translocation by the Sec complex" NARROW [] is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0043953 name: protein transport by the Tat complex namespace: biological_process def: "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. synonym: "protein secretion by the TAT complex" NARROW [] synonym: "protein translocation by the TAT complex" NARROW [] synonym: "protein translocation by the twin-arginine translocation complex" NARROW [] synonym: "twin-arginine translocation pathway" EXACT [] is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0043954 name: cellular component maintenance namespace: biological_process alt_id: GO:0071956 def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah] synonym: "cellular component maintenance at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0043955 name: 3-hydroxypropionyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT [] synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:6.2.1.36 xref: IMG:03293 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0043956 name: 3-hydroxypropionyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT [] synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:4.2.1.116 xref: IMG:03294 xref: MetaCyc:RXN-6383 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043957 name: acryloyl-CoA reductase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399] comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. synonym: "acetyl-coenzyme A synthetase" BROAD [] synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] synonym: "acryloyl-CoA reductase (NADPH) activity" EXACT [] synonym: "acrylyl-CoA reductase (NADPH) activity" EXACT [] synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:1.3.1.84 xref: IMG:03302 xref: KEGG_REACTION:R00919 xref: MetaCyc:RXN-9087 xref: RHEA:26456 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043958 name: acryloyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] comment: Note that this function is part of the process of L-alanine fermentation to propionate. synonym: "acryloyl-coenzyme A reductase activity" EXACT [] synonym: "acrylyl-CoA reductase (NADH)" EXACT [] synonym: "propionyl-CoA dehydrogenase" EXACT [] xref: EC:1.3.99.3 xref: IMG:01636 xref: MetaCyc:RXN-8568 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0043959 name: L-erythro-3-methylmalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303] synonym: "HpcH/HpaI aldolase" RELATED [] xref: EC:4.1.3.24 xref: IMG:03303 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0043960 name: L-erythro-3-methylmalyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl, IMG:03304] xref: IMG:03304 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0043961 name: succinyl-CoA:(R)-citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315] synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED [] synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT [] synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT [] xref: EC:2.8.3.20 xref: IMG:03306 xref: MetaCyc:RXN-8966 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0043962 name: obsolete negative regulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0043963 name: modulation by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0043964 name: induction by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT [] is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway [Term] id: GO:0043965 name: suppression by symbiont of host adenylate cyclase-mediated signal transduction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "negative regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT [] is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway [Term] id: GO:0043966 name: histone H3 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043967 name: histone H4 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043968 name: histone H2A acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043969 name: histone H2B acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation [Term] id: GO:0043970 name: histone H3-K9 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K9" EXACT [] synonym: "histone H3K9 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation is_a: GO:0061647 ! histone H3-K9 modification [Term] id: GO:0043971 name: histone H3-K18 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K18" EXACT [] synonym: "histone H3K18 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043972 name: histone H3-K23 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K23" EXACT [] synonym: "histone H3K23 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043973 name: histone H3-K4 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K4" EXACT [] synonym: "histone H3K4 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043974 name: histone H3-K27 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K27" EXACT [] synonym: "histone H3K27 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043975 name: histone H3-K36 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K36" EXACT [] synonym: "histone H3K36 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043976 name: histone H3-K79 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K79" EXACT [] synonym: "histone H3K79 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation [Term] id: GO:0043977 name: histone H2A-K5 acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H2A acetylation at K5" EXACT [] is_a: GO:0043968 ! histone H2A acetylation [Term] id: GO:0043978 name: histone H2A-K9 acetylation namespace: biological_process def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] synonym: "histone H2A acetylation at K9" EXACT [] is_a: GO:0043968 ! histone H2A acetylation [Term] id: GO:0043979 name: histone H2B-K5 acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H2B acetylation at K5" EXACT [] is_a: GO:0043969 ! histone H2B acetylation [Term] id: GO:0043980 name: histone H2B-K12 acetylation namespace: biological_process def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] synonym: "histone H2B acetylation at K12" EXACT [] is_a: GO:0043969 ! histone H2B acetylation [Term] id: GO:0043981 name: histone H4-K5 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K5" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043982 name: histone H4-K8 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K8" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043983 name: histone H4-K12 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K12" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043984 name: histone H4-K16 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K16" EXACT [] is_a: GO:0043967 ! histone H4 acetylation [Term] id: GO:0043985 name: histone H4-R3 methylation namespace: biological_process def: "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah] synonym: "histone H4 methylation at R3" EXACT [] synonym: "histone H4 R3 methylation" EXACT [] synonym: "histone H4R3me" EXACT [] is_a: GO:0034969 ! histone arginine methylation [Term] id: GO:0043987 name: histone H3-S10 phosphorylation namespace: biological_process alt_id: GO:0043986 def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl] synonym: "histone H3 phosphorylation at S10" EXACT [] synonym: "histone H3S10 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043988 name: histone H3-S28 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl] synonym: "histone H3 phosphorylation at S28" EXACT [] synonym: "histone H3S28 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043989 name: histone H4-S1 phosphorylation namespace: biological_process def: "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] synonym: "histone H4 phosphorylation at S1" EXACT [] synonym: "histone H4S1 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043990 name: histone H2A-S1 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] synonym: "histone H2A phosphorylation at S1" EXACT [] synonym: "histone H2AS1 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation is_a: GO:1990164 ! histone H2A phosphorylation [Term] id: GO:0043991 name: histone H2B-S14 phosphorylation namespace: biological_process def: "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl] synonym: "histone H2B phosphorylation at S14" EXACT [] synonym: "histone H2BS14 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation [Term] id: GO:0043992 name: histone acetyltransferase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043970 ! histone H3-K9 acetylation [Term] id: GO:0043993 name: histone acetyltransferase activity (H3-K18 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043971 ! histone H3-K18 acetylation [Term] id: GO:0043994 name: histone acetyltransferase activity (H3-K23 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043972 ! histone H3-K23 acetylation [Term] id: GO:0043995 name: histone acetyltransferase activity (H4-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity relationship: part_of GO:0043981 ! histone H4-K5 acetylation [Term] id: GO:0043996 name: histone acetyltransferase activity (H4-K8 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity relationship: part_of GO:0043982 ! histone H4-K8 acetylation [Term] id: GO:0043997 name: histone acetyltransferase activity (H4-K12 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity relationship: part_of GO:0043983 ! histone H4-K12 acetylation [Term] id: GO:0043998 name: H2A histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48] synonym: "H2A histone lysine N-acetyltransferase activity" EXACT [] is_a: GO:0004402 ! histone acetyltransferase activity relationship: part_of GO:0043968 ! histone H2A acetylation [Term] id: GO:0043999 name: histone acetyltransferase activity (H2A-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT [] is_a: GO:0043998 ! H2A histone acetyltransferase activity relationship: part_of GO:0043977 ! histone H2A-K5 acetylation [Term] id: GO:0044000 name: movement in host namespace: biological_process def: "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "movement of symbiont in host" EXACT [] synonym: "movement of symbiont within host" EXACT [] synonym: "movement within host" EXACT [] synonym: "symbiont movement in host" EXACT [] synonym: "symbiont movement within host" RELATED [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052126 ! movement in host environment [Term] id: GO:0044001 name: migration in host namespace: biological_process def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "migration within host" EXACT [] is_a: GO:0044000 ! movement in host is_a: GO:0051815 ! migration in other organism involved in symbiotic interaction [Term] id: GO:0044002 name: acquisition of nutrients from host namespace: biological_process def: "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] is_a: GO:0051701 ! interaction with host is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0044003 name: modification by symbiont of host morphology or physiology namespace: biological_process alt_id: GO:0044055 def: "The process in which a symbiont organism effects a change in the structure or processes of its host organism." [GOC:cc] synonym: "modulation by symbiont of host system process" NARROW [] synonym: "regulation by symbiont of host system process" NARROW [] is_a: GO:0051701 ! interaction with host is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0044004 name: disruption by symbiont of host cell namespace: biological_process def: "Any process in which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction [Term] id: GO:0044007 name: dissemination or transmission of symbiont from host namespace: biological_process def: "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "dissemination or transmission of organism from host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction [Term] id: GO:0044008 name: dissemination or transmission of symbiont from host by vector namespace: biological_process def: "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "dissemination or transmission of organism from host by vector" EXACT [] is_a: GO:0044007 ! dissemination or transmission of symbiont from host is_a: GO:0051822 ! dissemination or transmission of organism from other organism by vector involved in symbiotic interaction [Term] id: GO:0044009 name: viral transmission by vector namespace: biological_process def: "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc] is_a: GO:0019089 ! transmission of virus is_a: GO:0044008 ! dissemination or transmission of symbiont from host by vector [Term] id: GO:0044010 name: single-species biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb] is_a: GO:0042710 ! biofilm formation [Term] id: GO:0044011 name: single-species biofilm formation on inanimate substrate namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] is_a: GO:0051703 ! intraspecies interaction between organisms is_a: GO:0090609 ! single-species submerged biofilm formation [Term] id: GO:0044012 name: histone acetyltransferase activity (H2A-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT [] is_a: GO:0043998 ! H2A histone acetyltransferase activity relationship: part_of GO:0043978 ! histone H2A-K9 acetylation [Term] id: GO:0044013 name: H2B histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48] synonym: "H2B histone lysine N-acetyltransferase activity" EXACT [] is_a: GO:0004402 ! histone acetyltransferase activity relationship: part_of GO:0043969 ! histone H2B acetylation [Term] id: GO:0044014 name: histone acetyltransferase activity (H2B-K5 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT [] is_a: GO:0044013 ! H2B histone acetyltransferase activity relationship: part_of GO:0043979 ! histone H2B-K5 acetylation [Term] id: GO:0044015 name: histone acetyltransferase activity (H2B-K12 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT [] is_a: GO:0044013 ! H2B histone acetyltransferase activity relationship: part_of GO:0043980 ! histone H2B-K12 acetylation [Term] id: GO:0044016 name: histone acetyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043973 ! histone H3-K4 acetylation [Term] id: GO:0044017 name: histone acetyltransferase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043974 ! histone H3-K27 acetylation [Term] id: GO:0044018 name: histone acetyltransferase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity relationship: part_of GO:0043975 ! histone H3-K36 acetylation [Term] id: GO:0044019 name: histone acetyltransferase activity (H3-K72 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0044020 name: histone methyltransferase activity (H4-R3 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4." [GOC:mah, PMID:17898714] synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT [] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity relationship: part_of GO:0043985 ! histone H4-R3 methylation [Term] id: GO:0044022 name: histone kinase activity (H3-S28 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl] synonym: "histone serine kinase activity (H3-S28 specific)" EXACT [] synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0043988 ! histone H3-S28 phosphorylation [Term] id: GO:0044023 name: histone kinase activity (H4-S1 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl] synonym: "histone serine kinase activity (H4-S1 specific)" EXACT [] synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0043989 ! histone H4-S1 phosphorylation [Term] id: GO:0044024 name: histone kinase activity (H2A-S1 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl] synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT [] synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0043990 ! histone H2A-S1 phosphorylation [Term] id: GO:0044025 name: histone kinase activity (H2B-S14 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B." [GOC:jl] synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT [] synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT [] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0043991 ! histone H2B-S14 phosphorylation [Term] id: GO:0044026 name: DNA hypermethylation namespace: biological_process def: "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/] is_a: GO:0044030 ! regulation of DNA methylation [Term] id: GO:0044027 name: hypermethylation of CpG island namespace: biological_process def: "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] synonym: "DNA hypermethylation of CpG island" EXACT [] is_a: GO:0044026 ! DNA hypermethylation [Term] id: GO:0044028 name: DNA hypomethylation namespace: biological_process def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation] is_a: GO:0044030 ! regulation of DNA methylation [Term] id: GO:0044029 name: hypomethylation of CpG island namespace: biological_process def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] synonym: "DNA hypomethylation of CpG island" EXACT [] is_a: GO:0044028 ! DNA hypomethylation [Term] id: GO:0044030 name: regulation of DNA methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006306 ! DNA methylation relationship: regulates GO:0006306 ! DNA methylation [Term] id: GO:0044031 name: modification by symbiont of host protein by phosphorylation namespace: biological_process def: "The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that phosphorylate host proteins, consider annotation to 'protein amino acid phosphorylation ; GO:0006468'. Consider also annotation to the molecular function term 'protein kinase activity ; GO:0004672'. is_a: GO:0075345 ! modification by symbiont of host protein [Term] id: GO:0044032 name: modulation by symbiont of indole acetic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'. synonym: "modulation by symbiont of auxin levels in host" BROAD [] synonym: "modulation by symbiont of IAA levels in host" EXACT [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0044033 name: multi-organism metabolic process namespace: biological_process def: "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl] synonym: "multi-organism metabolism" EXACT [] synonym: "multi-organismal metabolic process" EXACT [] synonym: "multi-organismal metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044034 name: multi-organism biosynthetic process namespace: biological_process def: "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl] synonym: "multi-organism biosynthesis" EXACT [] synonym: "multi-organismal biosynthesis" EXACT [] synonym: "multi-organismal biosynthetic process" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044035 name: multi-organism catabolic process namespace: biological_process def: "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl] synonym: "multi-organism catabolism" EXACT [] synonym: "multi-organismal catabolic process" EXACT [] synonym: "multi-organismal catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044036 name: cell wall macromolecule metabolic process namespace: biological_process alt_id: GO:0010382 def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah] synonym: "cellular cell wall macromolecule metabolic process" EXACT [] synonym: "cellular cell wall macromolecule metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0044037 name: multi-organism cell wall macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators] synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah] is_a: GO:0044033 ! multi-organism metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0044038 name: cell wall macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators] synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah] synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah] synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0070589 ! cellular component macromolecule biosynthetic process relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0044040 name: multi-organism carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl] synonym: "main pathways of carbohydrate metabolic process" NARROW [] synonym: "main pathways of carbohydrate metabolism" NARROW [] synonym: "multi-organism carbohydrate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044033 ! multi-organism metabolic process [Term] id: GO:0044041 name: multi-organism carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl] synonym: "multi-organism carbohydrate breakdown" EXACT [] synonym: "multi-organism carbohydrate catabolism" EXACT [] synonym: "multi-organism carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044035 ! multi-organism catabolic process is_a: GO:0044040 ! multi-organism carbohydrate metabolic process [Term] id: GO:0044042 name: glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0044043 name: multi-organism glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684] synonym: "multi-organism glucan metabolism" EXACT [] is_a: GO:0044040 ! multi-organism carbohydrate metabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0044044 name: obsolete interaction with host via substance in symbiont surface namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process. is_obsolete: true [Term] id: GO:0044045 name: obsolete interaction with host via substance in symbiont cell outer membrane namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process. is_obsolete: true [Term] id: GO:0044046 name: obsolete interaction with host via substance released outside of symbiont namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via substance released outside of symbiont cells" EXACT [] is_obsolete: true [Term] id: GO:0044047 name: obsolete interaction with host via protein secreted by type I secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0044048 name: obsolete interaction with host via protein secreted by type V secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0044049 name: obsolete interaction with host via protein secreted by type VI secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0044050 name: obsolete interaction with host via substance released by sporangium lysis namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED [] synonym: "interaction with host via substance released by sporangia lysis" EXACT [] is_obsolete: true [Term] id: GO:0044051 name: obsolete interaction with host via substance released by symbiont cytolysis namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT [] is_obsolete: true [Term] id: GO:0044052 name: obsolete interaction with host via substance released by membrane budding namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via substance released by symbiont membrane budding" EXACT [] is_obsolete: true [Term] id: GO:0044053 name: translocation of peptides or proteins into host cell cytoplasm namespace: biological_process def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk] synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT [] synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT [] is_a: GO:0042000 ! translocation of peptides or proteins into host [Term] id: GO:0044054 name: rounding by symbiont of host cells namespace: biological_process def: "Any process in which an organism causes host cells to change shape and become round." [MITRE:tk] is_a: GO:0044004 ! disruption by symbiont of host cell [Term] id: GO:0044056 name: modulation by symbiont of host digestive system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk] synonym: "regulation by symbiont of host digestive system process" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0022600 ! digestive system process [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003008 ! system process relationship: regulates GO:0003008 ! system process [Term] id: GO:0044058 name: regulation of digestive system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022600 ! digestive system process relationship: regulates GO:0022600 ! digestive system process [Term] id: GO:0044059 name: modulation by symbiont of host endocrine process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk] synonym: "regulation by symbiont of host endocrine process" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0044060 ! regulation of endocrine process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0050886 ! endocrine process [Term] id: GO:0044060 name: regulation of endocrine process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] synonym: "regulation of endocrine system process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050886 ! endocrine process relationship: regulates GO:0050886 ! endocrine process [Term] id: GO:0044061 name: modulation by symbiont of host excretion namespace: biological_process def: "The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk] synonym: "regulation by symbiont of host excretion" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0044062 ! regulation of excretion [Term] id: GO:0044062 name: regulation of excretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] is_a: GO:0044057 ! regulation of system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007588 ! excretion relationship: regulates GO:0007588 ! excretion [Term] id: GO:0044063 name: modulation by symbiont of host nervous system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk] synonym: "modulation by symbiont of host neurological system process" EXACT [] synonym: "regulation by symbiont of host neurological system process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0050877 ! nervous system process [Term] id: GO:0044064 name: modulation by symbiont of host respiratory system process namespace: biological_process def: "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk] synonym: "regulation by symbiont of host respiratory system process" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0044065 ! regulation of respiratory system process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0003016 ! respiratory system process [Term] id: GO:0044065 name: regulation of respiratory system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003016 ! respiratory system process relationship: regulates GO:0003016 ! respiratory system process [Term] id: GO:0044066 name: modification by symbiont of host cell nucleus namespace: biological_process def: "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk] synonym: "modification by symbiont of host nucleus" EXACT [] synonym: "modification of host cell nucleus by symbiont" EXACT [] synonym: "modification of host nucleus by symbiont" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0044067 name: modification by symbiont of host intercellular junctions namespace: biological_process def: "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk] synonym: "modification of host intercellular junctions by symbiont" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component [Term] id: GO:0044068 name: modulation by symbiont of host cellular process namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk] synonym: "modulation of host cellular process by symbiont" EXACT [] synonym: "regulation by symbiont of host cellular process" EXACT [] synonym: "regulation of host cellular process by symbiont" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0009987 ! cellular process [Term] id: GO:0044069 name: modulation by symbiont of host anion transport namespace: biological_process def: "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk] synonym: "modification of host anion transport by symbiont" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0006820 ! anion transport [Term] id: GO:0044070 name: regulation of anion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006820 ! anion transport relationship: regulates GO:0006820 ! anion transport [Term] id: GO:0044071 name: modulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk] synonym: "modification by symbiont of host cell cycle" EXACT [] synonym: "modulation of host cell cycle by symbiont" EXACT [] synonym: "regulation by symbiont of host cell cycle" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0022402 ! cell cycle process [Term] id: GO:0044072 name: negative regulation by symbiont of host cell cycle namespace: biological_process def: "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0044071 ! modulation by symbiont of host cell cycle intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: negatively_regulates GO:0022402 ! cell cycle process [Term] id: GO:0044073 name: modulation by symbiont of host translation namespace: biological_process def: "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] synonym: "modification by symbiont of host translation" EXACT [] synonym: "modulation of host translation by symbiont" EXACT [] synonym: "regulation by symbiont of host translation" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0044074 name: negative regulation by symbiont of host translation namespace: biological_process def: "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] synonym: "negative regulation of host translation by symbiont" EXACT [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0044073 ! modulation by symbiont of host translation [Term] id: GO:0044075 name: modulation by symbiont of host vacuole organization namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah] synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah] synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0044088 ! regulation of vacuole organization [Term] id: GO:0044076 name: positive regulation by symbiont of host vacuole organization namespace: biological_process def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah] synonym: "positive regulation of host vacuole organization by symbiont" EXACT [] is_a: GO:0044075 ! modulation by symbiont of host vacuole organization is_a: GO:0044090 ! positive regulation of vacuole organization [Term] id: GO:0044077 name: modulation by symbiont of host receptor-mediated endocytosis namespace: biological_process def: "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT [] synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis [Term] id: GO:0044078 name: positive regulation by symbiont of host receptor-mediated endocytosis namespace: biological_process def: "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT [] is_a: GO:0044077 ! modulation by symbiont of host receptor-mediated endocytosis is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis [Term] id: GO:0044079 name: modulation by symbiont of host neurotransmitter secretion namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism." [MITRE:tk] synonym: "modification by symbiont of host neurotransmitter secretion" EXACT [] synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT [] synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT [] is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission is_a: GO:0046928 ! regulation of neurotransmitter secretion intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0044080 name: modulation by symbiont of host cGMP-mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk] synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT [] synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT [] synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT [] synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT [] synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT [] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044081 name: modulation by symbiont of host nitric oxide-mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk] synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT [] synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT [] synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT [] synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT [] synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044082 name: modulation by symbiont of host small GTPase mediated signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk] synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT [] synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT [] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0044083 name: modulation by symbiont of host Rho protein signal transduction namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk] synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT [] synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT [] synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT [] synonym: "modulation of host Rho protein signaling by symbiont" EXACT [] synonym: "modulation of host Rho protein signalling by symbiont" EXACT [] synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT [] is_a: GO:0035023 ! regulation of Rho protein signal transduction is_a: GO:0044082 ! modulation by symbiont of host small GTPase mediated signal transduction [Term] id: GO:0044084 name: host cell membrane pore complex namespace: cellular_component def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk] synonym: "pore complex in host cell membrane" EXACT [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044085 ! cellular component biogenesis relationship: regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007033 ! vacuole organization relationship: regulates GO:0007033 ! vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis relationship: positively_regulates GO:0044085 ! cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007033 ! vacuole organization relationship: positively_regulates GO:0007033 ! vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003674 ! molecular_function relationship: negatively_regulates GO:0003674 ! molecular_function created_by: jane creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003674 ! molecular_function relationship: positively_regulates GO:0003674 ! molecular_function created_by: jane creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044094 name: host cell nuclear part namespace: cellular_component def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0033646 ! host intracellular part relationship: part_of GO:0042025 ! host cell nucleus created_by: jane creation_date: 2009-04-22T01:59:14Z [Term] id: GO:0044095 name: host cell nucleoplasm namespace: cellular_component def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] is_a: GO:0044094 ! host cell nuclear part created_by: jane creation_date: 2009-04-22T02:02:51Z [Term] id: GO:0044096 name: type IV pilus namespace: cellular_component def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators] synonym: "TFP" EXACT [] synonym: "type 4 pilus" EXACT [] synonym: "type IV fimbriae" EXACT [] is_a: GO:0009289 ! pilus created_by: jane creation_date: 2009-04-22T02:52:55Z [Term] id: GO:0044097 name: secretion by the type IV secretion system namespace: biological_process def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] synonym: "secretion via the type IV secretion system" EXACT [] is_a: GO:0032940 ! secretion by cell created_by: jane creation_date: 2009-06-09T02:20:34Z [Term] id: GO:0044098 name: DNA secretion by the type IV secretion system namespace: biological_process def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] synonym: "DNA secretion via the type IV secretion system" EXACT [] is_a: GO:0044097 ! secretion by the type IV secretion system created_by: jane creation_date: 2009-06-09T02:26:57Z [Term] id: GO:0044099 name: polar tube namespace: cellular_component def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921] is_a: GO:0110165 ! cellular anatomical entity created_by: jane creation_date: 2009-06-09T03:12:32Z [Term] id: GO:0044100 name: sporoplasm namespace: cellular_component def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular created_by: jane creation_date: 2009-06-09T03:27:03Z [Term] id: GO:0044101 name: (R)-citramalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl, IMG:03307] synonym: "Ccl" RELATED [] synonym: "R-citramalyl-CoA lyase activity" EXACT [] xref: EC:4.1.3 xref: IMG:03307 xref: MetaCyc:RXN-8967 is_a: GO:0016833 ! oxo-acid-lyase activity created_by: jane creation_date: 2009-07-09T03:14:15Z [Term] id: GO:0044102 name: purine deoxyribosyltransferase activity namespace: molecular_function def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, IMG:03313, PMID:11836245] synonym: "PTD" RELATED [] synonym: "purine 2'-deoxyribosyltransferase activity" EXACT [] xref: IMG:03313 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups created_by: jane creation_date: 2009-07-09T03:40:15Z [Term] id: GO:0044103 name: L-arabinose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, IMG:03333] xref: IMG:03333 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: jane creation_date: 2009-07-09T04:00:30Z [Term] id: GO:0044104 name: 2,5-dioxovalerate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [IMG:03338, PMID:16835232, PMID:17202142] synonym: "2,5-dioxopentanoate dehydrogenase (NAD+) activity" EXACT [] synonym: "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity" EXACT [] xref: IMG:03338 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor created_by: jane creation_date: 2009-07-09T04:15:14Z [Term] id: GO:0044105 name: L-xylulose reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [IMG:03341, PMID:14736891] xref: EC:1.1.1.10 xref: IMG:03341 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: jane creation_date: 2009-07-09T04:25:43Z [Term] id: GO:0044106 name: cellular amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl] is_a: GO:0009308 ! amine metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process created_by: jane creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0044107 name: cellular alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044237 ! cellular metabolic process created_by: jane creation_date: 2009-07-15T01:36:19Z [Term] id: GO:0044108 name: cellular alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl] is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process created_by: jane creation_date: 2009-07-15T01:38:25Z [Term] id: GO:0044109 name: cellular alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl] is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046164 ! alcohol catabolic process created_by: jane creation_date: 2009-07-15T01:44:27Z [Term] id: GO:0044110 name: growth involved in symbiotic interaction namespace: biological_process alt_id: GO:0044153 def: "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'. synonym: "growth during symbiotic interaction" RELATED [GOC:dph] synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "growth on or near surface of other organism involved in symbiotic interaction" RELATED [] is_a: GO:0040007 ! growth is_a: GO:0044419 ! interspecies interaction between organisms created_by: jane creation_date: 2009-07-30T02:22:33Z [Term] id: GO:0044111 name: development involved in symbiotic interaction namespace: biological_process alt_id: GO:0044152 def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'. synonym: "development during symbiotic interaction" RELATED [gOC:dph] synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW [] is_a: GO:0032502 ! developmental process is_a: GO:0051704 ! multi-organism process intersection_of: GO:0032502 ! developmental process intersection_of: part_of GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044419 ! interspecies interaction between organisms created_by: jane creation_date: 2009-07-30T02:26:46Z [Term] id: GO:0044113 name: development in other organism involved in symbiotic interaction namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc] comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'growth in other organism during symbiotic interaction ; GO:0044112'. synonym: "development in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction created_by: jane creation_date: 2009-07-30T02:32:38Z [Term] id: GO:0044114 name: development of symbiont in host namespace: biological_process alt_id: GO:0044122 alt_id: GO:0044124 def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'growth of symbiont in host ; GO:0044117'. synonym: "development of symbiont in host intercellular space" NARROW [] synonym: "development of symbiont in host vascular tissue" NARROW [] is_a: GO:0044115 ! development of symbiont involved in interaction with host created_by: jane creation_date: 2009-07-30T03:39:25Z [Term] id: GO:0044115 name: development of symbiont involved in interaction with host namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'growth of symbiont in host ; GO:0044117'. synonym: "development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction created_by: jane creation_date: 2009-07-30T03:26:36Z [Term] id: GO:0044117 name: growth of symbiont in host namespace: biological_process alt_id: GO:0044112 alt_id: GO:0044116 alt_id: GO:0044123 alt_id: GO:0044125 def: "The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'development of symbiont in host ; GO:0044114'. synonym: "growth in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "growth in other organism involved in symbiotic interaction" RELATED [] synonym: "growth of symbiont during interaction with host" RELATED [GOC:tb] synonym: "growth of symbiont in host intercellular space" BROAD [] synonym: "growth of symbiont in host vascular tissue" NARROW [] synonym: "growth of symbiont involved in interaction with host" RELATED [] is_a: GO:0044110 ! growth involved in symbiotic interaction is_a: GO:0044403 ! symbiotic process created_by: jane creation_date: 2009-07-30T02:32:14Z [Term] id: GO:0044118 name: development of symbiont in host cell namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'growth of symbiont in host cell ; GO:0044119'. is_a: GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2009-07-30T03:52:00Z [Term] id: GO:0044119 name: growth of symbiont in host cell namespace: biological_process def: "The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'development of symbiont in host cell ; GO:0044118'. This term refers to an increase in mass of a symbiont in a host cell; it should not be used to annotate an increase in number of symbionts, e.g. viral replication in a host cell. is_a: GO:0044117 ! growth of symbiont in host created_by: jane creation_date: 2009-07-30T03:52:30Z [Term] id: GO:0044120 name: development of symbiont in host vacuole namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host organelle ; GO:0044121'. synonym: "development of symbiont in host organelle" BROAD [] is_a: GO:0044118 ! development of symbiont in host cell created_by: jane creation_date: 2009-07-30T03:59:54Z [Term] id: GO:0044121 name: growth of symbiont in host vacuole namespace: biological_process def: "The increase in size or mass of a symbiont, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host organelle ; GO:0044120'. synonym: "growth of symbiont in host organelle" BROAD [] is_a: GO:0044119 ! growth of symbiont in host cell created_by: jane creation_date: 2009-07-30T04:00:25Z [Term] id: GO:0044126 name: obsolete regulation of growth of symbiont in host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-04T02:10:08Z [Term] id: GO:0044127 name: regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'. is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044114 ! development of symbiont in host relationship: regulates GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2009-08-04T02:11:08Z [Term] id: GO:0044128 name: obsolete positive regulation of growth of symbiont in host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-04T02:20:57Z [Term] id: GO:0044129 name: positive regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'. is_a: GO:0044127 ! regulation of development of symbiont in host is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044114 ! development of symbiont in host relationship: positively_regulates GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2009-08-04T02:25:41Z [Term] id: GO:0044130 name: obsolete negative regulation of growth of symbiont in host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-04T02:42:25Z [Term] id: GO:0044131 name: negative regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'. is_a: GO:0044127 ! regulation of development of symbiont in host is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044114 ! development of symbiont in host relationship: negatively_regulates GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2009-08-04T02:42:56Z [Term] id: GO:0044132 name: development of symbiont on or near host namespace: biological_process def: "The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'growth of symbiont on or near host ; GO:0044133'. is_a: GO:0044115 ! development of symbiont involved in interaction with host created_by: jane creation_date: 2009-08-04T03:36:02Z [Term] id: GO:0044133 name: growth of symbiont on or near host namespace: biological_process def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'. is_a: GO:0044110 ! growth involved in symbiotic interaction created_by: jane creation_date: 2009-08-04T03:36:49Z [Term] id: GO:0044134 name: development of symbiont on or near host phyllosphere namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'growth of symbiont on or near host phyllosphere ; GO:0044135'. is_a: GO:0044132 ! development of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:10:58Z [Term] id: GO:0044135 name: growth of symbiont on or near host phyllosphere namespace: biological_process def: "The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'development of symbiont on or near host phyllosphere ; GO:0044134'. is_a: GO:0044133 ! growth of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:11:23Z [Term] id: GO:0044136 name: development of symbiont on or near host rhizosphere namespace: biological_process def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'growth of symbiont on or near host rhizosphere ; GO:0044137'. is_a: GO:0044132 ! development of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:18:35Z [Term] id: GO:0044137 name: growth of symbiont on or near host rhizosphere namespace: biological_process def: "The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'development of symbiont on or near host rhizosphere ; GO:0044136'. is_a: GO:0044133 ! growth of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:19:07Z [Term] id: GO:0044138 name: modulation of development of symbiont on or near host namespace: biological_process def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of growth of symbiont on or near host ; GO:0044139'. is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host relationship: regulates GO:0044132 ! development of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:24:25Z [Term] id: GO:0044139 name: obsolete modulation of growth of symbiont on or near host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-04T04:24:59Z [Term] id: GO:0044140 name: obsolete negative regulation of growth of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-04T04:31:26Z [Term] id: GO:0044141 name: negative regulation of development of symbiont on or near host surface namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'. is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host relationship: negatively_regulates GO:0044132 ! development of symbiont on or near host created_by: jane creation_date: 2009-08-04T04:32:18Z [Term] id: GO:0044142 name: obsolete positive regulation of growth of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. is_obsolete: true created_by: jane creation_date: 2009-08-06T01:35:18Z [Term] id: GO:0044143 name: positive regulation of development of symbiont on or near host surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'. is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host relationship: positively_regulates GO:0044132 ! development of symbiont on or near host created_by: jane creation_date: 2009-08-06T01:35:48Z [Term] id: GO:0044144 name: obsolete modulation of growth of symbiont involved in interaction with host namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. synonym: "modulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_obsolete: true created_by: jane creation_date: 2009-08-06T01:56:48Z [Term] id: GO:0044145 name: modulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0044115 ! development of symbiont involved in interaction with host created_by: jane creation_date: 2009-08-06T01:57:38Z [Term] id: GO:0044146 name: obsolete negative regulation of growth of symbiont involved in interaction with host namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. synonym: "negative regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_obsolete: true created_by: jane creation_date: 2009-08-06T02:04:24Z [Term] id: GO:0044147 name: negative regulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. synonym: "negative regulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044115 ! development of symbiont involved in interaction with host relationship: negatively_regulates GO:0044115 ! development of symbiont involved in interaction with host created_by: jane creation_date: 2009-08-06T02:04:59Z [Term] id: GO:0044148 name: obsolete positive regulation of growth of symbiont involved in interaction with host namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. synonym: "positive regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] is_obsolete: true created_by: jane creation_date: 2009-08-06T02:20:27Z [Term] id: GO:0044149 name: positive regulation of development of symbiont involved in interaction with host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. synonym: "positive regulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044115 ! development of symbiont involved in interaction with host relationship: positively_regulates GO:0044115 ! development of symbiont involved in interaction with host created_by: jane creation_date: 2009-08-06T02:20:55Z [Term] id: GO:0044150 name: development of host on or near symbiont surface namespace: biological_process def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] synonym: "development of organism on or near symbiont surface" EXACT [] is_a: GO:0044111 ! development involved in symbiotic interaction created_by: jane creation_date: 2009-08-06T03:15:52Z [Term] id: GO:0044151 name: growth of host on or near symbiont surface namespace: biological_process def: "The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] comment: This term partially replaces the obsolete term 'growth or development of organism on or near symbiont surface ; GO:0051857'. See also 'development of organism on or near symbiont surface ; GO:0044150'. synonym: "growth of organism on or near symbiont surface" EXACT [] is_a: GO:0044110 ! growth involved in symbiotic interaction created_by: jane creation_date: 2009-08-06T03:16:19Z [Term] id: GO:0044154 name: histone H3-K14 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708] synonym: "histone H3 acetylation at K14" EXACT [] synonym: "histone H3K14 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation created_by: jane creation_date: 2009-08-11T03:40:43Z [Term] id: GO:0044155 name: host caveola namespace: cellular_component def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane created_by: jane creation_date: 2009-08-11T04:00:55Z [Term] id: GO:0044156 name: host cell junction namespace: cellular_component def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph] is_a: GO:0033643 ! host cell part relationship: part_of GO:0020002 ! host cell plasma membrane created_by: jane creation_date: 2009-08-11T04:04:50Z [Term] id: GO:0044157 name: host cell projection namespace: cellular_component def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-08-11T04:07:24Z [Term] id: GO:0044158 name: host cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-08-11T04:09:23Z [Term] id: GO:0044159 name: host thylakoid namespace: cellular_component def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph] is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-08-11T04:15:34Z [Term] id: GO:0044160 name: host thylakoid membrane namespace: cellular_component def: "The pigmented membrane of any host thylakoid." [GOC:rph] is_a: GO:0033644 ! host cell membrane is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044159 ! host thylakoid created_by: jane creation_date: 2009-08-11T04:17:31Z [Term] id: GO:0044161 name: host cell cytoplasmic vesicle namespace: cellular_component def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-08-11T04:22:21Z [Term] id: GO:0044162 name: host cell cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph] is_a: GO:0033644 ! host cell membrane is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle created_by: jane creation_date: 2009-08-11T04:24:02Z [Term] id: GO:0044163 name: host cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph] is_a: GO:0033647 ! host intracellular organelle created_by: jane creation_date: 2009-08-11T04:27:04Z [Term] id: GO:0044164 name: host cell cytosol namespace: cellular_component def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl] synonym: "host cytosol" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-09-04T11:03:27Z [Term] id: GO:0044165 name: host cell endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl] synonym: "host endoplasmic reticulum" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-09-04T11:08:09Z [Term] id: GO:0044166 name: host cell endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl] synonym: "host endoplasmic reticulum lumen" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044165 ! host cell endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:13:30Z [Term] id: GO:0044167 name: host cell endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl] synonym: "host endoplasmic reticulum membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0033645 ! host cell endomembrane system relationship: part_of GO:0044165 ! host cell endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:19:23Z [Term] id: GO:0044168 name: host cell rough endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl] synonym: "host rough endoplasmic reticulum" EXACT [] is_a: GO:0044165 ! host cell endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:23:28Z [Term] id: GO:0044169 name: host cell rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl] synonym: "host rough endoplasmic reticulum membrane" EXACT [] is_a: GO:0044167 ! host cell endoplasmic reticulum membrane relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:30:38Z [Term] id: GO:0044170 name: host cell smooth endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl] synonym: "host smooth endoplasmic reticulum" EXACT [] is_a: GO:0044165 ! host cell endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:33:29Z [Term] id: GO:0044171 name: host cell smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl] synonym: "host smooth endoplasmic reticulum membrane" EXACT [] is_a: GO:0044167 ! host cell endoplasmic reticulum membrane relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum created_by: jane creation_date: 2009-09-04T11:46:00Z [Term] id: GO:0044172 name: host cell endoplasmic reticulum-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl, GOC:pr] synonym: "host cell ER-Golgi intermediate compartment" EXACT [] synonym: "host ER-Golgi intermediate compartment" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-09-04T02:44:07Z [Term] id: GO:0044173 name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl] synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT [] synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] synonym: "host ER-Golgi intermediate compartment membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment created_by: jane creation_date: 2009-09-04T02:46:13Z [Term] id: GO:0044174 name: host cell endosome namespace: cellular_component def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl] synonym: "host endosome" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-09-04T03:02:01Z [Term] id: GO:0044175 name: host cell endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl] synonym: "host endosome membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044174 ! host cell endosome created_by: jane creation_date: 2009-09-04T03:04:04Z [Term] id: GO:0044176 name: host cell filopodium namespace: cellular_component def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl] synonym: "host filopodium" EXACT [] is_a: GO:0044157 ! host cell projection created_by: jane creation_date: 2009-09-04T03:06:59Z [Term] id: GO:0044177 name: host cell Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] synonym: "host Golgi apparatus" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-09-04T03:14:38Z [Term] id: GO:0044178 name: host cell Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl] synonym: "host Golgi membrane" EXACT [] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0033645 ! host cell endomembrane system relationship: part_of GO:0044177 ! host cell Golgi apparatus created_by: jane creation_date: 2009-09-04T03:16:14Z [Term] id: GO:0044179 name: hemolysis in other organism namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl] subset: goslim_chembl synonym: "hemolysis of cells in other organism" EXACT [GOC:bf] synonym: "hemolysis of erythrocytes in other organism" EXACT [] synonym: "hemolysis of RBCs in other organism" EXACT [] synonym: "hemolysis of red blood cells in other organism" EXACT [] is_a: GO:0051715 ! cytolysis in other organism created_by: jane creation_date: 2009-09-04T03:36:00Z [Term] id: GO:0044180 name: filamentous growth of a unicellular organism namespace: biological_process def: "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth created_by: jane creation_date: 2009-09-25T10:16:01Z [Term] id: GO:0044181 name: filamentous growth of a multicellular organism namespace: biological_process def: "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth is_a: GO:0060560 ! developmental growth involved in morphogenesis created_by: jane creation_date: 2009-09-25T10:17:58Z [Term] id: GO:0044182 name: filamentous growth of a population of unicellular organisms namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth created_by: jane creation_date: 2009-09-25T10:18:32Z [Term] id: GO:0044183 name: protein folding chaperone namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009] subset: goslim_chembl synonym: "chaperone activity" BROAD [] synonym: "protein binding involved in protein folding" EXACT [] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: has_part GO:0005515 ! protein binding intersection_of: part_of GO:0006457 ! protein folding relationship: has_part GO:0005515 ! protein binding relationship: part_of GO:0006457 ! protein folding created_by: jane creation_date: 2009-09-25T11:33:48Z [Term] id: GO:0044184 name: host cell late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl] is_a: GO:0044174 ! host cell endosome created_by: jane creation_date: 2009-10-15T02:58:34Z [Term] id: GO:0044185 name: host cell late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl] is_a: GO:0044175 ! host cell endosome membrane relationship: part_of GO:0044184 ! host cell late endosome created_by: jane creation_date: 2009-10-15T03:00:39Z [Term] id: GO:0044186 name: host cell lipid droplet namespace: cellular_component def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl] synonym: "host cell lipid adiposome" EXACT [] synonym: "host cell lipid body" EXACT [] synonym: "host cell lipid particle" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-10-15T03:05:06Z [Term] id: GO:0044187 name: host cell lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-10-15T03:26:00Z [Term] id: GO:0044188 name: host cell lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044187 ! host cell lysosome created_by: jane creation_date: 2009-10-15T03:27:54Z [Term] id: GO:0044189 name: obsolete host cell microsome namespace: cellular_component def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl] comment: This term was obsoleted because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "host cell microsomal membrane" EXACT [] synonym: "host cell microsome" EXACT [] is_obsolete: true consider: GO:0033648 created_by: jane creation_date: 2009-10-15T04:04:24Z [Term] id: GO:0044190 name: host cell mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0033650 ! host cell mitochondrion created_by: jane creation_date: 2009-10-15T04:12:55Z [Term] id: GO:0044191 name: host cell mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044190 ! host cell mitochondrial envelope created_by: jane creation_date: 2009-10-15T04:14:35Z [Term] id: GO:0044192 name: host cell mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl] is_a: GO:0044191 ! host cell mitochondrial membrane created_by: jane creation_date: 2009-10-15T04:17:29Z [Term] id: GO:0044193 name: host cell mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl] is_a: GO:0039661 ! host organelle outer membrane is_a: GO:0044191 ! host cell mitochondrial membrane created_by: jane creation_date: 2009-10-15T04:18:44Z [Term] id: GO:0044194 name: cytolytic granule namespace: cellular_component def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758] is_a: GO:0005764 ! lysosome created_by: jane creation_date: 2009-10-20T01:22:13Z [Term] id: GO:0044195 name: nucleoplasmic reticulum namespace: cellular_component def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685] synonym: "nuclear channels" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005635 ! nuclear envelope created_by: jane creation_date: 2009-10-20T02:24:09Z [Term] id: GO:0044196 name: host cell nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl] is_a: GO:0044094 ! host cell nuclear part created_by: jane creation_date: 2009-10-20T02:37:07Z [Term] id: GO:0044197 name: Rel homology domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [InterPro:IPR011539, Wikipedia:Rel_homology_domain] synonym: "RHD binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding created_by: jane creation_date: 2009-10-20T03:57:48Z [Term] id: GO:0044198 name: zf-TRAF domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293] synonym: "TRAF-type zinc finger domain binding" EXACT [] synonym: "zinc finger TRAF-type domain binding" EXACT [] synonym: "zinc-finger-TRAF domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding created_by: jane creation_date: 2009-10-20T04:09:08Z [Term] id: GO:0044199 name: host cell nuclear envelope namespace: cellular_component def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl] is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0033645 ! host cell endomembrane system created_by: jane creation_date: 2009-10-21T10:56:11Z [Term] id: GO:0044200 name: host cell nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl] is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0044199 ! host cell nuclear envelope created_by: jane creation_date: 2009-10-21T10:59:08Z [Term] id: GO:0044201 name: host cell nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl] is_a: GO:0044200 ! host cell nuclear membrane created_by: jane creation_date: 2009-10-21T11:08:33Z [Term] id: GO:0044202 name: host cell nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl] is_a: GO:0039661 ! host organelle outer membrane is_a: GO:0044200 ! host cell nuclear membrane created_by: jane creation_date: 2009-10-21T11:10:23Z [Term] id: GO:0044203 name: host cell nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl] is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0044201 ! host cell nuclear inner membrane created_by: jane creation_date: 2009-10-21T11:11:56Z [Term] id: GO:0044204 name: host cell nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl] is_a: GO:0044094 ! host cell nuclear part created_by: jane creation_date: 2009-10-21T11:15:36Z [Term] id: GO:0044205 name: 'de novo' UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] synonym: "'de novo' UMP biosynthesis" EXACT [] is_a: GO:0006222 ! UMP biosynthetic process created_by: jane creation_date: 2009-10-21T11:27:31Z [Term] id: GO:0044206 name: UMP salvage namespace: biological_process def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496] synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT [] synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT [] is_a: GO:0006222 ! UMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage created_by: jane creation_date: 2009-10-21T11:32:33Z [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm created_by: jane creation_date: 2009-10-22T02:38:55Z [Term] id: GO:0044208 name: 'de novo' AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601] is_a: GO:0006167 ! AMP biosynthetic process created_by: jane creation_date: 2009-10-22T02:48:30Z [Term] id: GO:0044209 name: AMP salvage namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350] synonym: "adenosine monophosphate salvage" EXACT [] synonym: "AMP biosynthetic process via salvage pathway" EXACT [] is_a: GO:0006167 ! AMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage created_by: jane creation_date: 2009-10-22T02:52:11Z [Term] id: GO:0044210 name: 'de novo' CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916] synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT [] is_a: GO:0006241 ! CTP biosynthetic process created_by: jane creation_date: 2009-10-22T03:22:34Z [Term] id: GO:0044211 name: CTP salvage namespace: biological_process def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935] synonym: "CTP biosynthetic process via salvage pathway" EXACT [] synonym: "cytidine 5'-triphosphate salvage" EXACT [] is_a: GO:0006241 ! CTP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage created_by: jane creation_date: 2009-10-22T03:24:04Z [Term] id: GO:0044212 name: transcription regulatory region DNA binding namespace: molecular_function alt_id: GO:0000975 def: "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". synonym: "regulatory region DNA binding" BROAD [] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003677 ! DNA binding created_by: kchris creation_date: 2009-11-04T12:58:25Z [Term] id: GO:0044213 name: intronic transcription regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within." [GOC:ecd, GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding created_by: jane creation_date: 2009-11-04T01:21:28Z [Term] id: GO:0044214 name: spanning component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd] comment: Proteins that span the membrane but have the bulk on one side of the membrane may be additionally annotated with a term of the form integral to X side of the plasma membrane. synonym: "fully spanning plasma membrane" EXACT [] synonym: "transmembrane" RELATED [GOC:mah] is_a: GO:0005887 ! integral component of plasma membrane is_a: GO:0089717 ! spanning component of membrane intersection_of: GO:0089717 ! spanning component of membrane intersection_of: part_of GO:0005886 ! plasma membrane created_by: jane creation_date: 2009-11-04T01:50:57Z [Term] id: GO:0044215 name: obsolete other organism namespace: cellular_component def: "OBSOLETE. A secondary organism with which the first organism is interacting." [GOC:jl] comment: This term was obsoleted because it represents an organism, which is outside the scope of GO. is_obsolete: true created_by: jane creation_date: 2009-11-12T01:04:58Z [Term] id: GO:0044216 name: other organism cell namespace: cellular_component def: "A cell of a secondary organism with which the first organism is interacting." [GOC:jl] is_a: GO:0044217 ! other organism part created_by: jane creation_date: 2009-11-12T01:17:06Z [Term] id: GO:0044217 name: other organism part namespace: cellular_component def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0005575 ! cellular_component created_by: jane creation_date: 2009-11-12T01:18:21Z [Term] id: GO:0044218 name: other organism cell membrane namespace: cellular_component alt_id: GO:0044279 def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl] synonym: "foreign membrane" RELATED [] synonym: "other organism membrane" BROAD [] is_a: GO:0044217 ! other organism part relationship: part_of GO:0044216 ! other organism cell created_by: jane creation_date: 2009-11-12T02:37:44Z [Term] id: GO:0044219 name: host cell plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph] is_a: GO:0044156 ! host cell junction created_by: jane creation_date: 2009-11-12T02:50:52Z [Term] id: GO:0044220 name: host cell perinuclear region of cytoplasm namespace: cellular_component def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph] is_a: GO:0033655 ! host cell cytoplasm part created_by: jane creation_date: 2009-11-12T02:58:13Z [Term] id: GO:0044221 name: host cell synapse namespace: cellular_component def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-11-12T03:03:59Z [Term] id: GO:0044222 name: anammoxosome namespace: cellular_component def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm created_by: jane creation_date: 2009-11-12T04:03:24Z [Term] id: GO:0044223 name: pirellulosome namespace: cellular_component def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm created_by: jane creation_date: 2009-11-12T04:08:07Z [Term] id: GO:0044224 name: juxtaparanode region of axon namespace: cellular_component def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359] synonym: "juxta paranode axon" RELATED [NIF_Subcellular:sao1191319089] synonym: "juxtaparanodal region" EXACT [] synonym: "juxtaparanode" EXACT [] xref: NIF_Subcellular:sao758620702 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044304 ! main axon created_by: jane creation_date: 2009-11-13T12:57:36Z [Term] id: GO:0044225 name: apical pole of neuron namespace: cellular_component def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860] xref: NIF_Subcellular:sao1186862860 is_a: GO:0060187 ! cell pole relationship: part_of GO:0043025 ! neuronal cell body created_by: jane creation_date: 2009-11-13T03:49:14Z [Term] id: GO:0044226 name: basal pole of neuron namespace: cellular_component def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860] xref: NIF_Subcellular:sao1186862860 is_a: GO:0060187 ! cell pole relationship: part_of GO:0043025 ! neuronal cell body created_by: jane creation_date: 2009-11-13T04:32:17Z [Term] id: GO:0044227 name: methane-oxidizing organelle namespace: cellular_component def: "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh] synonym: "methane-oxidizing compartment" EXACT [] synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm created_by: jane creation_date: 2009-11-17T02:13:52Z [Term] id: GO:0044228 name: host cell surface namespace: cellular_component def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-12-03T01:49:45Z [Term] id: GO:0044229 name: host cell periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-12-03T01:52:31Z [Term] id: GO:0044230 name: host cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph] is_a: GO:0033643 ! host cell part created_by: jane creation_date: 2009-12-03T03:24:03Z [Term] id: GO:0044231 name: host cell presynaptic membrane namespace: cellular_component alt_id: GO:0072556 def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph] synonym: "host cell pre-synaptic membrane" EXACT [] synonym: "other organism pre-synaptic membrane" RELATED [] synonym: "other organism presynaptic membrane" RELATED [] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane relationship: part_of GO:0044221 ! host cell synapse created_by: jane creation_date: 2009-12-08T02:11:18Z [Term] id: GO:0044232 name: organelle membrane contact site namespace: cellular_component def: "A zone of apposition between the membranes of an organelle with another membrane, either that of another organelle or the plasma membrane, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880] synonym: "inter-organelle junction" EXACT [] synonym: "interorganelle junction" EXACT [] synonym: "MCS" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043226 ! organelle created_by: jane creation_date: 2010-01-07T03:44:20Z [Term] id: GO:0044233 name: mitochondria-associated endoplasmic reticulum membrane namespace: cellular_component def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109] synonym: "endoplasmic reticulum-mitochondrion membrane contact site" EXACT [] synonym: "ER-mitochondrion membrane contact site" EXACT [] synonym: "MAM" RELATED [] synonym: "mitochondria-associated ER membrane" EXACT [] synonym: "Mitochondria-associated Membrane" RELATED [] synonym: "mitochondria-associated membrane" EXACT [] synonym: "mitochondria-endoplasmic reticulum (ER) contact" EXACT [PMID:29870872] is_a: GO:0044232 ! organelle membrane contact site created_by: jane creation_date: 2010-01-07T04:07:24Z [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0044239 name: obsolete salivary polysaccharide catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/] comment: The reason for obsoletion is that this term represents the location of a process, which should be captured by the relation 'occurs in'. synonym: "salivary polysaccharide breakdown" EXACT [] synonym: "salivary polysaccharide catabolism" EXACT [] synonym: "salivary polysaccharide degradation" EXACT [] is_obsolete: true consider: GO:0000272 [Term] id: GO:0044241 name: lipid digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] is_a: GO:0007586 ! digestion [Term] id: GO:0044242 name: cellular lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl] synonym: "cellular lipid breakdown" EXACT [] synonym: "cellular lipid catabolism" EXACT [] synonym: "cellular lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0044245 name: polysaccharide digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] is_a: GO:0007586 ! digestion [Term] id: GO:0044247 name: cellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [GOC:jl] synonym: "cellular polysaccharide breakdown" EXACT [] synonym: "cellular polysaccharide catabolism" EXACT [] synonym: "cellular polysaccharide degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0044248 name: cellular catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044250 name: negative regulation of metabolic activity involved in hibernation namespace: biological_process def: "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation] synonym: "down regulation of metabolic activity during hibernation" RELATED [] synonym: "down-regulation of metabolic activity during hibernation" RELATED [] synonym: "downregulation of metabolic activity during hibernation" RELATED [] synonym: "inhibition of metabolic activity during hibernation" NARROW [] synonym: "negative regulation of metabolic activity during hibernation" RELATED [GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process relationship: part_of GO:0042750 ! hibernation [Term] id: GO:0044251 name: obsolete protein catabolic process by pepsin namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/] comment: The reason for obsoletion is that this term represents a specific gene product. synonym: "protein breakdown by pepsin" EXACT [] synonym: "protein degradation by pepsin" EXACT [] is_obsolete: true consider: GO:0030163 [Term] id: GO:0044255 name: cellular lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] subset: goslim_pir synonym: "cellular lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044256 name: protein digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] is_a: GO:0007586 ! digestion [Term] id: GO:0044257 name: cellular protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl] synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0044258 name: intestinal lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/] synonym: "intestinal lipid breakdown" EXACT [] synonym: "intestinal lipid catabolism" EXACT [] synonym: "intestinal lipid degradation" EXACT [] is_a: GO:0016042 ! lipid catabolic process [Term] id: GO:0044260 name: cellular macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah] synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044262 name: cellular carbohydrate metabolic process namespace: biological_process alt_id: GO:0006092 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] synonym: "cellular carbohydrate metabolism" EXACT [] synonym: "main pathways of carbohydrate metabolic process" NARROW [] synonym: "main pathways of carbohydrate metabolism" NARROW [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0044264 name: cellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] synonym: "cellular glycan metabolic process" EXACT [] synonym: "cellular glycan metabolism" EXACT [] synonym: "cellular polysaccharide metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0044265 name: cellular macromolecule catabolic process namespace: biological_process alt_id: GO:0034962 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [GOC:jl] synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule breakdown" EXACT [] synonym: "cellular macromolecule catabolism" EXACT [] synonym: "cellular macromolecule degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044267 name: cellular protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] synonym: "cellular protein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0044269 name: glycerol ether catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl] synonym: "glycerol ether breakdown" EXACT [] synonym: "glycerol ether catabolism" EXACT [] synonym: "glycerol ether degradation" EXACT [] is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0044270 name: cellular nitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound breakdown" BROAD [] synonym: "nitrogen compound catabolism" BROAD [] synonym: "nitrogen compound degradation" BROAD [] xref: MIPS_funcat:01.02.01.09 is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044272 name: sulfur compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur biosynthesis" NARROW [] synonym: "sulfur biosynthetic process" NARROW [] synonym: "sulfur compound anabolism" EXACT [] synonym: "sulfur compound biosynthesis" EXACT [] synonym: "sulfur compound formation" EXACT [] synonym: "sulfur compound synthesis" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0044273 name: sulfur compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] synonym: "sulfur catabolic process" NARROW [] synonym: "sulfur catabolism" NARROW [] synonym: "sulfur compound breakdown" EXACT [] synonym: "sulfur compound catabolism" EXACT [] synonym: "sulfur compound degradation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0044275 name: cellular carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] synonym: "cellular carbohydrate breakdown" EXACT [] synonym: "cellular carbohydrate catabolism" EXACT [] synonym: "cellular carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0044277 name: cell wall disassembly namespace: biological_process alt_id: GO:0060871 def: "A process that results in the breakdown of the cell wall." [GOC:jl] synonym: "cellular cell wall disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0071555 ! cell wall organization created_by: jane creation_date: 2010-01-14T02:00:34Z [Term] id: GO:0044278 name: cell wall disruption in other organism namespace: biological_process def: "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl] is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: jane creation_date: 2010-01-14T02:01:48Z [Term] id: GO:0044280 name: subplasmalemmal coating namespace: cellular_component def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839] xref: NIF_Subcellular:sao1938587839 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane created_by: jane creation_date: 2010-01-14T03:58:38Z [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jane creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process created_by: jane creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process created_by: jane creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044284 name: mitochondrial crista junction namespace: cellular_component def: "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane." [GOC:mcc, NIF_Subcellular:sao1825845900, PMID:21944719, PMID:21987634, PMID:22009199] synonym: "crista junction" EXACT [] synonym: "cristae junction" EXACT [] xref: NIF_Subcellular:sao1825845900 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005743 ! mitochondrial inner membrane created_by: jane creation_date: 2010-02-02T10:07:39Z [Term] id: GO:0044285 name: bridge contact site namespace: cellular_component def: "Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes." [NIF_Subcellular:sao1858501007] xref: NIF_Subcellular:sao1858501007 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031966 ! mitochondrial membrane created_by: jane creation_date: 2010-02-02T10:12:13Z [Term] id: GO:0044286 name: peg and socket contact namespace: cellular_component def: "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898] synonym: "ball and socket contact" EXACT [GOC:tfm, PMID:17591898] xref: NIF_Subcellular:sao1943947957 is_a: GO:0044291 ! cell-cell contact zone created_by: jane creation_date: 2010-02-02T10:15:27Z [Term] id: GO:0044288 name: puncta adhaerentia namespace: cellular_component def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430] xref: NIF_Subcellular:sao257629430 is_a: GO:0005915 ! zonula adherens created_by: jane creation_date: 2010-02-04T02:19:38Z [Term] id: GO:0044289 name: contact site namespace: cellular_component def: "Sites of close apposition of the inner and outer mitochondrial membrane." [NIF_Subcellular:sao447856407] xref: NIF_Subcellular:sao447856407 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031966 ! mitochondrial membrane created_by: jane creation_date: 2010-02-04T02:25:11Z [Term] id: GO:0044290 name: mitochondrial intracristal space namespace: cellular_component def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414] xref: NIF_Subcellular:sao508958414 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005739 ! mitochondrion created_by: jane creation_date: 2010-02-04T02:32:10Z [Term] id: GO:0044291 name: cell-cell contact zone namespace: cellular_component def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] synonym: "cell cell contact zone" EXACT [] xref: NIF_Subcellular:sao1299635018 is_a: GO:0005911 ! cell-cell junction created_by: jane creation_date: 2010-02-04T02:42:54Z [Term] id: GO:0044292 name: dendrite terminus namespace: cellular_component def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] synonym: "dendrite terminal" EXACT [] synonym: "dendrite terminal specialization" RELATED [] synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134] synonym: "terminal specialization of a dendrite" EXACT [] xref: NIF_Subcellular:sao28175134 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030425 ! dendrite created_by: jane creation_date: 2010-02-04T03:14:37Z [Term] id: GO:0044293 name: dendriole namespace: cellular_component def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904] xref: NIF_Subcellular:sao28175134 xref: NIF_Subcellular:sao295057932 is_a: GO:0044292 ! dendrite terminus created_by: jane creation_date: 2010-02-04T03:32:02Z [Term] id: GO:0044294 name: dendritic growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl] synonym: "dendrite growth cone" EXACT [] xref: NIF_Subcellular:sao1594955670 is_a: GO:0030426 ! growth cone is_a: GO:0044292 ! dendrite terminus created_by: jane creation_date: 2010-02-04T03:45:27Z [Term] id: GO:0044295 name: axonal growth cone namespace: cellular_component def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954] synonym: "axon growth cone" EXACT [] xref: NIF_Subcellular:sao1594955670 xref: NIF_Subcellular:sao203987954 is_a: GO:0030426 ! growth cone created_by: jane creation_date: 2010-02-04T03:57:16Z [Term] id: GO:0044296 name: dendritic tuft namespace: cellular_component def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079] synonym: "dendrite tuft" EXACT [] xref: NIF_Subcellular:sao1340260079 is_a: GO:0044292 ! dendrite terminus created_by: jane creation_date: 2010-02-04T04:03:29Z [Term] id: GO:0044297 name: cell body namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. synonym: "cell soma" EXACT [] xref: FBbt:00005107 xref: FMA:67301 xref: Wikipedia:Cell_body is_a: GO:0110165 ! cellular anatomical entity created_by: jane creation_date: 2010-02-05T10:37:16Z [Term] id: GO:0044298 name: cell body membrane namespace: cellular_component def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd] synonym: "cell soma membrane" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0044297 ! cell body created_by: jane creation_date: 2010-02-05T10:39:23Z [Term] id: GO:0044299 name: C-fiber namespace: cellular_component def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210] synonym: "C-fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090210 is_a: GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T11:14:51Z [Term] id: GO:0044300 name: cerebellar mossy fiber namespace: cellular_component def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209] synonym: "cerebellar mossy fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090209 is_a: GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T11:16:40Z [Term] id: GO:0044301 name: climbing fiber namespace: cellular_component def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203] synonym: "climbing fibre" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090203 is_a: GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T11:20:56Z [Term] id: GO:0044302 name: dentate gyrus mossy fiber namespace: cellular_component def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709] synonym: "dentate gyrus mossy fibre" EXACT [] synonym: "granule cell axon" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090601 is_a: GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T11:23:55Z [Term] id: GO:0044303 name: axon collateral namespace: cellular_component def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754] xref: NIF_Subcellular:sao1470140754 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T11:29:04Z [Term] id: GO:0044304 name: main axon namespace: cellular_component def: "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044] synonym: "axon shaft" RELATED [PMID:11264310, PMID:24312009] synonym: "axon trunk" EXACT [] synonym: "axonal shaft" RELATED [PMID:11264310, PMID:24312009] xref: NIF_Subcellular:sao1596975044 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T03:48:17Z [Term] id: GO:0044305 name: calyx of Held namespace: cellular_component def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805] xref: NIF_Subcellular:sao1684283879 is_a: GO:0043679 ! axon terminus created_by: jane creation_date: 2010-02-05T02:33:20Z [Term] id: GO:0044306 name: neuron projection terminus namespace: cellular_component def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl] synonym: "nerve terminal" RELATED [PMID:25972809, PMID:9650842] synonym: "neuron projection terminal" EXACT [] synonym: "neuron terminal specialization" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043005 ! neuron projection created_by: jane creation_date: 2010-02-05T02:44:04Z [Term] id: GO:0044307 name: dendritic branch namespace: cellular_component def: "A dendrite arising from another dendrite." [GOC:aruk, GOC:bc, NIF_Subcellular:sao884265541] synonym: "dendrite branch" EXACT [] synonym: "secondary dendrite" NARROW [PMID:25431552] xref: NIF_Subcellular:sao884265541 is_a: GO:0030425 ! dendrite created_by: jane creation_date: 2010-02-05T04:18:53Z [Term] id: GO:0044308 name: axonal spine namespace: cellular_component def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917] synonym: "axon spine" EXACT [] xref: NIF_Subcellular:sao18239917 is_a: GO:0044309 ! neuron spine relationship: part_of GO:0030424 ! axon created_by: jane creation_date: 2010-02-05T04:22:13Z [Term] id: GO:0044309 name: neuron spine namespace: cellular_component def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102] synonym: "spine" BROAD [] xref: NIF_Subcellular:sao1145756102 is_a: GO:0043005 ! neuron projection created_by: jane creation_date: 2010-02-05T04:25:10Z [Term] id: GO:0044310 name: osmiophilic body namespace: cellular_component def: "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189] is_a: GO:0031410 ! cytoplasmic vesicle created_by: jane creation_date: 2010-02-18T03:18:32Z [Term] id: GO:0044311 name: exoneme namespace: cellular_component def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex created_by: jane creation_date: 2010-02-18T03:29:56Z [Term] id: GO:0044312 name: crystalloid namespace: cellular_component def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm created_by: jane creation_date: 2010-02-18T03:58:55Z [Term] id: GO:0044313 name: protein K6-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp] is_a: GO:0016579 ! protein deubiquitination created_by: jane creation_date: 2010-06-01T03:10:11Z [Term] id: GO:0044314 name: protein K27-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326] synonym: "protein K27-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination created_by: jane creation_date: 2010-06-02T11:48:08Z [Term] id: GO:0044315 name: protein secretion by the type VII secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport created_by: jane creation_date: 2010-06-02T11:57:05Z [Term] id: GO:0044316 name: cone cell pedicle namespace: cellular_component def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [http://webvision.med.utah.edu/photo2.html, PMID:10939333] synonym: "cone pedicle" EXACT [] is_a: GO:0043679 ! axon terminus created_by: jane creation_date: 2010-07-14T01:30:02Z [Term] id: GO:0044317 name: rod spherule namespace: cellular_component def: "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [http://webvision.med.utah.edu/photo2.html] synonym: "rod cell spherule" EXACT [] synonym: "rod photoreceptor spherule" EXACT [] is_a: GO:0043005 ! neuron projection created_by: jane creation_date: 2010-07-14T01:38:07Z [Term] id: GO:0044318 name: L-aspartate:fumarate oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100] comment: This is based on the finding that L-aspartate oxidase (NadB) of E. coli preferentially uses fumarate as the electron acceptor and does so under anaerobic conditions. The same enzyme uses oxygen as the electron acceptor under aerobic conditions. The EC conflates the two reactions in EC 1.4.3.16 (as they are catalyzed by the same enzyme). xref: EC:1.4.3.16 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors created_by: jane creation_date: 2010-07-14T01:50:01Z [Term] id: GO:0044319 name: wound healing, spreading of cells namespace: biological_process def: "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl] synonym: "cell migration involved in wound healing epiboly" EXACT [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0090505 ! epiboly involved in wound healing relationship: part_of GO:0090505 ! epiboly involved in wound healing created_by: jane creation_date: 2010-07-14T02:10:01Z [Term] id: GO:0044320 name: cellular response to leptin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0044321 ! response to leptin created_by: jane creation_date: 2010-07-14T02:21:32Z [Term] id: GO:0044321 name: response to leptin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf] synonym: "response to leptin stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone created_by: jane creation_date: 2010-07-14T02:31:20Z [Term] id: GO:0044322 name: endoplasmic reticulum quality control compartment namespace: cellular_component def: "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579] synonym: "ER quality control compartment" EXACT [] synonym: "ER-derived quality control compartment" RELATED [] synonym: "ERQC" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005783 ! endoplasmic reticulum created_by: janelomax creation_date: 2010-08-03T01:12:59Z [Term] id: GO:0044323 name: retinoic acid-responsive element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "RARE binding" EXACT [] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: janelomax creation_date: 2010-08-03T03:19:05Z [Term] id: GO:0044324 name: regulation of transcription involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: janelomax creation_date: 2010-08-04T12:35:41Z [Term] id: GO:0044325 name: ion channel binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:BHF, GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding created_by: janelomax creation_date: 2010-08-04T12:52:59Z [Term] id: GO:0044326 name: dendritic spine neck namespace: cellular_component def: "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln] synonym: "neck" BROAD [NIF_Subcellular:sao1642908940] synonym: "pedicle" RELATED [NIF_Subcellular:sao1642908940] synonym: "spine neck" BROAD [NIF_Subcellular:sao1642908940] xref: NIF_Subcellular:sao1642908940 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043197 ! dendritic spine created_by: janelomax creation_date: 2010-08-18T02:31:15Z [Term] id: GO:0044327 name: dendritic spine head namespace: cellular_component def: "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:BHF, GOC:nln, GOC:rl] synonym: "spine head" BROAD [NIF_Subcellular:sao952643730] xref: NIF_Subcellular:sao952643730 is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0014069 ! postsynaptic density relationship: part_of GO:0043197 ! dendritic spine created_by: janelomax creation_date: 2010-08-18T02:33:12Z [Term] id: GO:0044328 name: canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0010595 ! positive regulation of endothelial cell migration relationship: part_of GO:0010595 ! positive regulation of endothelial cell migration created_by: janelomax creation_date: 2010-08-18T04:01:05Z [Term] id: GO:0044329 name: canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0022409 ! positive regulation of cell-cell adhesion relationship: part_of GO:0022409 ! positive regulation of cell-cell adhesion created_by: janelomax creation_date: 2010-08-18T04:16:50Z [Term] id: GO:0044330 name: canonical Wnt signaling pathway involved in positive regulation of wound healing namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of wound healing" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0090303 ! positive regulation of wound healing relationship: part_of GO:0090303 ! positive regulation of wound healing created_by: janelomax creation_date: 2010-08-18T04:21:21Z [Term] id: GO:0044331 name: cell-cell adhesion mediated by cadherin namespace: biological_process def: "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970] is_a: GO:0098609 ! cell-cell adhesion created_by: janelomax creation_date: 2010-08-20T10:24:54Z [Term] id: GO:0044332 name: Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf] synonym: "Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0009950 ! dorsal/ventral axis specification relationship: part_of GO:0009950 ! dorsal/ventral axis specification created_by: janelomax creation_date: 2010-08-20T11:30:30Z [Term] id: GO:0044333 name: Wnt signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl] synonym: "Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] synonym: "Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis created_by: janelomax creation_date: 2010-08-20T11:36:23Z [Term] id: GO:0044334 name: canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition relationship: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition created_by: janelomax creation_date: 2010-08-20T02:35:17Z [Term] id: GO:0044335 name: canonical Wnt signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0014033 ! neural crest cell differentiation relationship: part_of GO:0014033 ! neural crest cell differentiation created_by: janelomax creation_date: 2010-08-20T03:02:34Z [Term] id: GO:0044336 name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis" NARROW [] synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0043066 ! negative regulation of apoptotic process relationship: part_of GO:0043066 ! negative regulation of apoptotic process created_by: janelomax creation_date: 2010-08-20T03:07:53Z [Term] id: GO:0044337 name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis" NARROW [] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0043065 ! positive regulation of apoptotic process relationship: part_of GO:0043065 ! positive regulation of apoptotic process created_by: janelomax creation_date: 2010-08-20T03:08:24Z [Term] id: GO:0044338 name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0072497 ! mesenchymal stem cell differentiation relationship: part_of GO:0072497 ! mesenchymal stem cell differentiation created_by: janelomax creation_date: 2010-08-20T03:43:36Z [Term] id: GO:0044339 name: canonical Wnt signaling pathway involved in osteoblast differentiation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0001649 ! osteoblast differentiation relationship: part_of GO:0001649 ! osteoblast differentiation created_by: janelomax creation_date: 2010-08-20T03:52:11Z [Term] id: GO:0044340 name: canonical Wnt signaling pathway involved in regulation of cell proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl] synonym: "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0008283 ! cell population proliferation relationship: part_of GO:0008283 ! cell population proliferation relationship: part_of GO:0042127 ! regulation of cell population proliferation created_by: janelomax creation_date: 2010-08-20T03:57:25Z [Term] id: GO:0044341 name: sodium-dependent phosphate transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl] is_a: GO:0006817 ! phosphate ion transport created_by: janelomax creation_date: 2010-08-20T04:16:15Z [Term] id: GO:0044342 name: type B pancreatic cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "pancreatic beta cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation created_by: janelomax creation_date: 2010-08-25T01:44:51Z [Term] id: GO:0044343 name: canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] synonym: "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" RELATED [] synonym: "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:signaling] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0061469 ! regulation of type B pancreatic cell proliferation relationship: part_of GO:0061469 ! regulation of type B pancreatic cell proliferation created_by: janelomax creation_date: 2010-08-25T01:53:22Z [Term] id: GO:0044344 name: cellular response to fibroblast growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf] synonym: "cellular response to FGF stimulus" EXACT [] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071774 ! response to fibroblast growth factor created_by: janelomax creation_date: 2010-08-25T02:00:51Z [Term] id: GO:0044345 name: stromal-epithelial cell signaling involved in prostate gland development namespace: biological_process def: "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl, GOC:yaf] synonym: "stromal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030850 ! prostate gland development created_by: janelomax creation_date: 2010-08-25T02:06:34Z [Term] id: GO:0044346 name: fibroblast apoptotic process namespace: biological_process def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf] synonym: "fibroblast apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process created_by: janelomax creation_date: 2010-09-23T11:33:38Z [Term] id: GO:0044347 name: cell wall polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides." [GOC:mengo_curators] synonym: "cell wall polysaccharide breakdown" EXACT [GOC:mah] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0016998 ! cell wall macromolecule catabolic process created_by: janelomax creation_date: 2011-07-28T01:24:57Z [Term] id: GO:0044348 name: plant-type cell wall cellulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall." [GOC:mengo_curators] synonym: "plant-type cell wall polysaccharide breakdown" EXACT [GOC:mah] is_a: GO:0044347 ! cell wall polysaccharide catabolic process is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process created_by: janelomax creation_date: 2011-07-28T01:48:23Z [Term] id: GO:0044349 name: DNA excision namespace: biological_process def: "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised." [GOC:jl] is_a: GO:0006259 ! DNA metabolic process created_by: janelomax creation_date: 2011-08-03T10:56:37Z [Term] id: GO:0044350 name: micropinocytosis namespace: biological_process alt_id: GO:1902540 def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm." [PMID:14731589, PMID:14732047] synonym: "clathrin-independent pinocytosis" BROAD [] synonym: "single-organism micropinocytosis" RELATED [] is_a: GO:0006907 ! pinocytosis created_by: janelomax creation_date: 2013-12-02T14:26:30Z [Term] id: GO:0044351 name: macropinocytosis namespace: biological_process alt_id: GO:1902538 def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047] synonym: "clathrin-independent pinocytosis" BROAD [] synonym: "single-organism macropinocytosis" RELATED [] is_a: GO:0006907 ! pinocytosis created_by: jl creation_date: 2011-08-11T10:26:42Z [Term] id: GO:0044352 name: pinosome namespace: cellular_component def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis." [PMID:14731589, PMID:14732047] synonym: "pinocytic vesicle" EXACT [NIF_Subcellular:sao1925368674] xref: NIF_Subcellular:sao1925368674 is_a: GO:0005768 ! endosome created_by: janelomax creation_date: 2011-08-11T10:51:13Z [Term] id: GO:0044353 name: micropinosome namespace: cellular_component def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis." [PMID:14731589, PMID:14732047] is_a: GO:0044352 ! pinosome created_by: janelomax creation_date: 2011-08-11T10:51:27Z [Term] id: GO:0044354 name: macropinosome namespace: cellular_component def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis." [PMID:14732047] is_a: GO:0044352 ! pinosome created_by: janelomax creation_date: 2011-08-11T10:51:42Z [Term] id: GO:0044355 name: clearance of foreign intracellular DNA namespace: biological_process def: "A defense process that protects an organism from invading foreign DNA." [GO:jl] is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids created_by: janelomax creation_date: 2011-08-11T11:25:43Z [Term] id: GO:0044356 name: clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine namespace: biological_process def: "A defense process that protects an organism from invading foreign DNA. The process begins by the deamination of foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are then converted by a uracil DNA glycosylase to abasic lesions, and the process ends with the degradation of the foreign DNA." [GO:jl, PMID:20062055] is_a: GO:0044355 ! clearance of foreign intracellular DNA created_by: janelomax creation_date: 2011-08-11T11:27:07Z [Term] id: GO:0044357 name: regulation of rRNA stability namespace: biological_process def: "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." [GOC:jl] synonym: "regulation of ribosomal RNA stability" EXACT [] is_a: GO:0043487 ! regulation of RNA stability is_a: GO:1902374 ! regulation of rRNA catabolic process created_by: janelomax creation_date: 2011-08-31T09:57:54Z [Term] id: GO:0044358 name: envenomation resulting in hemorrhagic damage to other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism." [PMID:10441379, PMID:20614020] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism created_by: janelomax creation_date: 2011-10-26T04:24:59Z [Term] id: GO:0044359 name: modulation of molecular function in other organism namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl] is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: janelomax creation_date: 2011-10-27T01:28:16Z [Term] id: GO:0044360 name: modulation of voltage-gated potassium channel activity in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl] is_a: GO:0044363 ! modulation of potassium channel activity in other organism created_by: janelomax creation_date: 2011-10-27T02:09:28Z [Term] id: GO:0044361 name: negative regulation of voltage-gated potassium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl] is_a: GO:0044360 ! modulation of voltage-gated potassium channel activity in other organism is_a: GO:0044362 ! negative regulation of molecular function in other organism created_by: janelomax creation_date: 2011-10-27T02:11:52Z [Term] id: GO:0044362 name: negative regulation of molecular function in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0044359 ! modulation of molecular function in other organism created_by: janelomax creation_date: 2011-10-27T02:12:49Z [Term] id: GO:0044363 name: modulation of potassium channel activity in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism." [GOC:jl] is_a: GO:0044561 ! modulation of ion channel activity in other organism created_by: janelomax creation_date: 2011-10-27T02:19:32Z [Term] id: GO:0044364 name: disruption of cells of other organism namespace: biological_process def: "A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl] is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: janelomax creation_date: 2011-10-27T02:27:48Z [Term] id: GO:0044365 name: envenomation resulting in modulation of platelet aggregation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in regulation of platelet aggregation in other organism" EXACT [] is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0035892 ! modulation of platelet aggregation in other organism relationship: has_part GO:0035892 ! modulation of platelet aggregation in other organism created_by: janelomax creation_date: 2011-10-27T02:36:43Z [Term] id: GO:0044366 name: feeding on or from other organism namespace: biological_process def: "The process of consuming the whole or part of another organism for the purposes of nutrition." [GOC:jl] comment: This term covers more than feeding behavior, including, for example, the processes of feeding by plants and fungi. is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2011-10-27T03:30:30Z [Term] id: GO:0044367 name: feeding from tissue of other organism namespace: biological_process def: "The behaviour of consuming part of another organism for the purposes of nutrition via a particular tissue e.g. vascular tissue." [GOC:jl] is_a: GO:0044366 ! feeding on or from other organism created_by: janelomax creation_date: 2011-10-27T03:31:23Z [Term] id: GO:0044368 name: feeding from vascular tissue of another organism namespace: biological_process def: "The behaviour of consuming part of another organism for the purposes of nutrition via a vascular tissue." [GOC:jl] is_a: GO:0044367 ! feeding from tissue of other organism created_by: janelomax creation_date: 2011-10-27T03:52:32Z [Term] id: GO:0044369 name: feeding on blood of other organism namespace: biological_process def: "The behaviour of feeding on the blood of another organism via specialized mouth parts and chemical agents used to penetrate vascular structures in the skin of hosts." [GOC:jl] synonym: "hematophagy" EXACT [] synonym: "phlebotomy" EXACT [] synonym: "taking of blood meal" EXACT [] is_a: GO:0044368 ! feeding from vascular tissue of another organism created_by: janelomax creation_date: 2011-10-27T03:53:33Z [Term] id: GO:0044370 name: injection of substance into other organism during feeding on blood of other organism namespace: biological_process def: "The process of forcing a substance into the bloodstream of another organism, whilst feeding on blood of other organism. The substance may facilitate the feeding process, e.g. by preventing the blood from clotting." [GOC:jl] is_a: GO:0035737 ! injection of substance in to other organism relationship: part_of GO:0044369 ! feeding on blood of other organism created_by: janelomax creation_date: 2011-10-27T03:57:28Z [Term] id: GO:0044371 name: feeding from phloem of other organism namespace: biological_process def: "The behaviour of consuming phloem sap, usually by penetration of the phloem wall, for the purposes of nutrition." [GOC:jl] synonym: "feeding from plant phloem" EXACT [] synonym: "feeding on plant sap" EXACT [] is_a: GO:0044368 ! feeding from vascular tissue of another organism created_by: janelomax creation_date: 2011-10-27T04:06:52Z [Term] id: GO:0044372 name: feeding from xylem of other organism namespace: biological_process def: "The behaviour of consuming xylem exudate from plant xylem tissue for the purposes of nutrition." [GOC:jl] synonym: "feeding from plant xylem" EXACT [] synonym: "feeding from xylem of plant" EXACT [] synonym: "feeding on xylem exudate" EXACT [] is_a: GO:0044368 ! feeding from vascular tissue of another organism created_by: janelomax creation_date: 2011-10-27T04:42:45Z [Term] id: GO:0044373 name: cytokinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators." [GOC:jl] is_a: GO:0042562 ! hormone binding created_by: janelomax creation_date: 2011-12-01T03:42:10Z [Term] id: GO:0044374 name: sequence-specific DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw] synonym: "DNA bending involving sequence-specific DNA binding" EXACT [] is_a: GO:0008301 ! DNA binding, bending is_a: GO:1990837 ! sequence-specific double-stranded DNA binding created_by: janelomax creation_date: 2011-12-01T04:05:59Z [Term] id: GO:0044375 name: regulation of peroxisome size namespace: biological_process def: "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] is_a: GO:0032535 ! regulation of cellular component size created_by: janelomax creation_date: 2011-12-01T04:37:59Z [Term] id: GO:0044376 name: obsolete RNA polymerase II complex import to nucleus namespace: biological_process alt_id: GO:0098738 def: "OBSOLETE. The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus." [GOC:dos, GOC:jl] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "DNA-directed RNA polymerase II core complex import into nucleus" EXACT [GO:0098738] synonym: "DNA-directed RNA polymerase II core complex localization to nucleus" EXACT [] synonym: "RNA polymerase II complex import into nucleus" EXACT [] synonym: "RNA polymerase II complex localisation to nucleus" EXACT [GOC:mah] is_obsolete: true consider: GO:0006606 created_by: janelomax creation_date: 2011-12-01T04:43:03Z [Term] id: GO:0044377 name: RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending namespace: molecular_function def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:pg] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending" RELATED [] synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding, bending" RELATED [] synonym: "RNA polymerase II proximal promoter region sequence-specific DNA binding, bending" RELATED [] synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding, bending" RELATED [] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding is_a: GO:0044374 ! sequence-specific DNA binding, bending created_by: janelomax creation_date: 2011-12-08T01:38:21Z [Term] id: GO:0044378 name: non-sequence-specific DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079] synonym: "DNA bending involving non-sequence-specific DNA binding" EXACT [] is_a: GO:0008301 ! DNA binding, bending created_by: janelomax creation_date: 2011-12-08T02:02:13Z [Term] id: GO:0044379 name: protein localization to actin cortical patch namespace: biological_process def: "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704] synonym: "protein localisation to actin cortical patch" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:1903119 ! protein localization to actin cytoskeleton created_by: janelomax creation_date: 2011-12-08T02:28:42Z [Term] id: GO:0044380 name: protein localization to cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle created_by: janelomax creation_date: 2011-12-13T11:43:24Z [Term] id: GO:0044381 name: glucose import in response to insulin stimulus namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [GOC:BHF, PMID:19079291] synonym: "cellular glucose import in response to insulin stimulus" EXACT [] is_a: GO:0046323 ! glucose import relationship: part_of GO:0032869 ! cellular response to insulin stimulus created_by: janelomax creation_date: 2011-12-08T02:44:01Z [Term] id: GO:0044382 name: CLRC ubiquitin ligase complex localization to heterochromatin namespace: biological_process def: "The process by which a CLRC ubiquitin ligase complex is transported to, or maintained in, heterochromatin. CLRC ubiquitin ligase complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:jl] synonym: "CLRC ubiquitin ligase complex localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization is_a: GO:0097355 ! protein localization to heterochromatin created_by: janelomax creation_date: 2011-12-13T03:37:18Z [Term] id: GO:0044383 name: host chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell." [GOC:jl] is_a: GO:0033647 ! host intracellular organelle created_by: janelomax creation_date: 2011-12-13T03:58:38Z [Term] id: GO:0044384 name: host outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell." [GOC:jl] comment: This term covers the outer membrane of the host cell envelope or the outer membrane of a host organelle. For the outer layer of the host cell envelope specifically, see host cell outer membrane ; GO:0039662. synonym: "host cell outer membrane" RELATED [GOC:bf] is_a: GO:0033644 ! host cell membrane created_by: janelomax creation_date: 2011-12-13T04:02:07Z [Term] id: GO:0044385 name: integral to membrane of host cell namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell." [GOC:jl] is_a: GO:0033643 ! host cell part relationship: part_of GO:0033644 ! host cell membrane created_by: janelomax creation_date: 2011-12-13T04:08:03Z [Term] id: GO:0044386 name: integral to host endoplasmic reticulum membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell." [GOC:jl] is_a: GO:0044385 ! integral to membrane of host cell relationship: part_of GO:0044167 ! host cell endoplasmic reticulum membrane created_by: janelomax creation_date: 2011-12-13T04:11:30Z [Term] id: GO:0044387 name: negative regulation of protein kinase activity by regulation of protein phosphorylation namespace: biological_process def: "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase." [GOC:jl] is_a: GO:0006469 ! negative regulation of protein kinase activity created_by: janelomax creation_date: 2011-12-13T04:49:36Z [Term] id: GO:0044388 name: small protein activating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl] is_a: GO:0019899 ! enzyme binding created_by: janelomax creation_date: 2011-12-15T04:28:17Z [Term] id: GO:0044389 name: ubiquitin-like protein ligase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] synonym: "E3 protein ligase binding" EXACT [] synonym: "small conjugating protein ligase binding" EXACT [GOC:dph] is_a: GO:0019899 ! enzyme binding created_by: janelomax creation_date: 2011-12-15T04:33:20Z [Term] id: GO:0044390 name: ubiquitin-like protein conjugating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl] synonym: "E2 protein ligase binding" EXACT [] synonym: "small protein conjugating enzyme binding" EXACT [GOC:dph] is_a: GO:0019899 ! enzyme binding created_by: janelomax creation_date: 2011-12-15T04:38:44Z [Term] id: GO:0044391 name: ribosomal subunit namespace: cellular_component def: "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005840 ! ribosome created_by: janelomax creation_date: 2011-12-15T04:47:59Z [Term] id: GO:0044392 name: peptidyl-lysine malonylation namespace: biological_process def: "The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568] synonym: "lysine malonylation" EXACT [PMID:21908771] xref: RESID:AA0568 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0044394 ! protein malonylation created_by: rfoulger creation_date: 2011-12-12T09:31:42Z [Term] id: GO:0044393 name: microspike namespace: cellular_component def: "A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735] comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'. is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: rfoulger creation_date: 2011-12-06T01:31:16Z [Term] id: GO:0044394 name: protein malonylation namespace: biological_process def: "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp] is_a: GO:0043543 ! protein acylation created_by: rfoulger creation_date: 2011-12-12T09:26:37Z [Term] id: GO:0044395 name: protein targeting to vacuolar membrane namespace: biological_process def: "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein." [GOC:jl] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:1903778 ! protein localization to vacuolar membrane created_by: janelomax creation_date: 2011-12-21T02:54:44Z [Term] id: GO:0044396 name: actin cortical patch organization namespace: biological_process def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl] synonym: "actin cortical patch organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization created_by: janelomax creation_date: 2011-12-21T03:33:25Z [Term] id: GO:0044397 name: actin cortical patch internalization namespace: biological_process def: "A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah] is_a: GO:0044396 ! actin cortical patch organization is_a: GO:0051666 ! actin cortical patch localization relationship: has_part GO:0030041 ! actin filament polymerization created_by: janelomax creation_date: 2011-12-21T03:37:11Z [Term] id: GO:0044398 name: envenomation resulting in induction of edema in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation." [GOC:jl, PMID:20562011] synonym: "envenomation resulting in induction of oedema in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism created_by: janelomax creation_date: 2011-12-21T03:57:27Z [Term] id: GO:0044399 name: multi-species biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb] is_a: GO:0042710 ! biofilm formation is_a: GO:0044403 ! symbiotic process [Term] id: GO:0044400 name: multi-species biofilm formation on inanimate substrate namespace: biological_process def: "A process in which microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc] is_a: GO:0090608 ! multi-species submerged biofilm formation [Term] id: GO:0044401 name: multi-species biofilm formation in or on host organism namespace: biological_process def: "A process in which microorganisms of different species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0044406 ! adhesion of symbiont to host is_a: GO:0090608 ! multi-species submerged biofilm formation [Term] id: GO:0044402 name: competition with other organism namespace: biological_process def: "Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc] synonym: "competition with another organism" EXACT [GOC:bf] synonym: "interspecies competition" BROAD [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0044403 name: symbiotic process namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, https://study.com/academy/lesson/symbiont-definition-lesson-quiz.html] comment: Changed term, definition see https://github.com/geneontology/go-ontology/issues/14807 subset: goslim_chembl subset: goslim_generic synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0044405 name: detection of host namespace: biological_process def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "recognition of host" EXACT [] is_a: GO:0075136 ! response to host is_a: GO:0098543 ! detection of other organism [Term] id: GO:0044406 name: adhesion of symbiont to host namespace: biological_process alt_id: GO:0051825 alt_id: GO:0051856 def: "The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:cc, GOC:dos, GOC:jl] comment: This term can be used to annotate both symbiont and host organisms. Consider also annotating to interaction with host ; GO:0051702, or interaction with symbiont ; GO:0051702. synonym: "adhesion to host" NARROW [] synonym: "adhesion to other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "adhesion to other organism involved in symbiotic interaction" EXACT [] synonym: "adhesion to symbiont" NARROW [] synonym: "host adhesion" NARROW [] is_a: GO:0022610 ! biological adhesion is_a: GO:0044403 ! symbiotic process [Term] id: GO:0044407 name: single-species biofilm formation in or on host organism namespace: biological_process def: "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0044408 name: obsolete growth or development of symbiont on or near host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host ; GO:0044133' and 'development of symbiont on or near host ; GO:0044132'. synonym: "growth or development of organism on or near host surface" EXACT [] synonym: "growth or development of symbiont on or near host" EXACT [] is_obsolete: true consider: GO:0044132 consider: GO:0044133 [Term] id: GO:0044409 name: entry into host namespace: biological_process alt_id: GO:0051828 def: "Penetration by a symbiont into the body, tissues, or cells of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "entry into other organism involved in symbiotic interaction" RELATED [] synonym: "host invasion" EXACT [] synonym: "host penetration" EXACT [GOC:vw] synonym: "invasion into host" EXACT [] synonym: "invasion into other organism" RELATED [] synonym: "invasion of host" EXACT [] synonym: "invasion of other organism" RELATED [] synonym: "invasive growth" RELATED [] synonym: "other organism invasion" RELATED [] synonym: "penetration into host" EXACT [GOC:vw] is_a: GO:0051701 ! interaction with host [Term] id: GO:0044410 name: entry into host through natural portals namespace: biological_process alt_id: GO:0051829 def: "Penetration by a symbiont into a host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "entry into other organism through natural portals during symbiotic interaction" RELATED [GOC:tb] synonym: "entry into other organism through natural portals involved in symbiotic interaction" RELATED [] is_a: GO:0044409 ! entry into host [Term] id: GO:0044412 name: obsolete growth or development of symbiont in host namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host ; GO:0044114' and 'growth of symbiont in host ; GO:0044117'. synonym: "growth or development of organism within host" EXACT [] synonym: "growth or development of symbiont in host" EXACT [] synonym: "growth or development of symbiont within host" EXACT [] synonym: "invasive growth" BROAD [] is_obsolete: true consider: GO:0044114 consider: GO:0044117 [Term] id: GO:0044414 name: suppression of host defenses by symbiont namespace: biological_process alt_id: GO:0051833 alt_id: GO:0052037 alt_id: GO:0052261 def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "down regulation by symbiont of host defense response" EXACT [] synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by symbiont of host defense response" EXACT [] synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" RELATED [] synonym: "downregulation by symbiont of host defense response" EXACT [] synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [] synonym: "inhibition by symbiont of host defense response" NARROW [] synonym: "negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT [] synonym: "negative regulation by symbiont of host defense response" EXACT [] synonym: "negative regulation of host defenses" EXACT [] synonym: "suppression of defense response of other organism" EXACT [] synonym: "suppression of defense response of other organism involved in symbiotic interaction" RELATED [] synonym: "suppression of defenses of other organism involved in symbiotic interaction" BROAD [] synonym: "suppression of host defense response" EXACT [] is_a: GO:0030682 ! mitigation of host defenses by symbiont is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0044416 name: induction by symbiont of host defense response namespace: biological_process alt_id: GO:0052251 alt_id: GO:0052509 alt_id: GO:0052510 def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "activation by symbiont of host defense response" EXACT [] synonym: "activation of host defense response" EXACT [] synonym: "induction by organism of defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of host defense response" RELATED [] synonym: "stimulation by symbiont of host defense response" RELATED [] synonym: "up regulation by symbiont of host defense response" RELATED [] synonym: "up-regulation by symbiont of host defense response" RELATED [] synonym: "upregulation by symbiont of host defense response" RELATED [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0044417 name: translocation of molecules into host namespace: biological_process alt_id: GO:0051836 def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "translocation of molecules into other organism during symbiotic interaction" BROAD [GOC:dph] synonym: "translocation of molecules into other organism involved in symbiotic interaction" BROAD [] synonym: "transport of molecules into host" EXACT [] synonym: "transport of molecules into other organism during symbiotic interaction" BROAD [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0044418 name: translocation of DNA into host namespace: biological_process alt_id: GO:0051837 def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "translocation of DNA into other organism during symbiotic interaction" BROAD [GOC:tb] synonym: "translocation of DNA into other organism involved in symbiotic interaction" BROAD [] synonym: "transport of DNA into host" EXACT [] synonym: "transport of DNA into other organism during symbiotic interaction" BROAD [] is_a: GO:0044417 ! translocation of molecules into host [Term] id: GO:0044419 name: interspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc] subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044420 name: obsolete extracellular matrix component namespace: cellular_component def: "OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "extracellular matrix part" EXACT [] is_obsolete: true consider: GO:0031012 [Term] id: GO:0044421 name: obsolete extracellular region part namespace: cellular_component def: "OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "extracellular structure" RELATED [NIF_Subcellular:sao9117790637] xref: NIF_Subcellular:sao9117790637 is_obsolete: true consider: GO:0005576 [Term] id: GO:0044422 name: obsolete organelle part namespace: cellular_component def: "OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0043226 [Term] id: GO:0044423 name: virion part namespace: cellular_component def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0019012 ! virion relationship: part_of GO:0019012 ! virion [Term] id: GO:0044424 name: obsolete intracellular part namespace: cellular_component def: "OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005622 [Term] id: GO:0044425 name: obsolete membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0016020 [Term] id: GO:0044426 name: obsolete cell wall part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005618 [Term] id: GO:0044427 name: obsolete chromosomal part namespace: cellular_component def: "OBSOLETE. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "chromosomal component" EXACT [] synonym: "chromosome component" EXACT [] synonym: "chromosome part" EXACT [] is_obsolete: true consider: GO:0005694 [Term] id: GO:0044428 name: obsolete nuclear part namespace: cellular_component def: "OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686] synonym: "nucleus component" EXACT [] xref: NIF_Subcellular:sao1499850686 is_obsolete: true consider: GO:0005634 [Term] id: GO:0044429 name: obsolete mitochondrial part namespace: cellular_component def: "OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040] synonym: "mitochondrion component" EXACT [] xref: NIF_Subcellular:sao666410040 is_obsolete: true consider: GO:0005739 [Term] id: GO:0044430 name: obsolete cytoskeletal part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413] synonym: "cytoskeleton component" EXACT [] xref: NIF_Subcellular:sao1635329413 is_obsolete: true consider: GO:0005856 [Term] id: GO:0044431 name: obsolete Golgi apparatus part namespace: cellular_component def: "OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "Golgi component" EXACT [] synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949] xref: NIF_Subcellular:sao624292949 is_obsolete: true consider: GO:0005794 [Term] id: GO:0044432 name: obsolete endoplasmic reticulum part namespace: cellular_component def: "OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "ER component" EXACT [] is_obsolete: true consider: GO:0005783 [Term] id: GO:0044433 name: obsolete cytoplasmic vesicle part namespace: cellular_component def: "OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0031410 [Term] id: GO:0044434 name: obsolete chloroplast part namespace: cellular_component def: "OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009507 [Term] id: GO:0044435 name: obsolete plastid part namespace: cellular_component def: "OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009536 [Term] id: GO:0044436 name: obsolete thylakoid part namespace: cellular_component def: "OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0009579 [Term] id: GO:0044437 name: obsolete vacuolar part namespace: cellular_component def: "OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "vacuole component" EXACT [] is_obsolete: true consider: GO:0005773 [Term] id: GO:0044438 name: obsolete microbody part namespace: cellular_component def: "OBSOLETE. Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0042579 [Term] id: GO:0044439 name: obsolete peroxisomal part namespace: cellular_component def: "OBSOLETE. Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "peroxisome component" EXACT [] is_obsolete: true consider: GO:0005777 [Term] id: GO:0044440 name: obsolete endosomal part namespace: cellular_component def: "OBSOLETE. Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "endosomal subcomponent" EXACT [NIF_Subcellular:sao1683772610] synonym: "endosome component" EXACT [] xref: NIF_Subcellular:sao1683772610 is_obsolete: true consider: GO:0005768 [Term] id: GO:0044441 name: obsolete ciliary part namespace: cellular_component alt_id: GO:0044442 def: "OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. subset: gocheck_do_not_annotate synonym: "cilial part" EXACT [] synonym: "cilium part" EXACT [] synonym: "flagellar part" NARROW [] synonym: "flagellum component" NARROW [] synonym: "flagellum part" NARROW [] synonym: "microtubule-based flagellum part" EXACT [] is_obsolete: true consider: GO:0005929 [Term] id: GO:0044443 name: obsolete pilus part namespace: cellular_component def: "OBSOLETE. Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "fimbrial part" EXACT [] synonym: "fimbrium component" EXACT [] synonym: "pilus component" EXACT [] is_obsolete: true consider: GO:0009289 [Term] id: GO:0044444 name: obsolete cytoplasmic part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytoplasm component" EXACT [] is_obsolete: true consider: GO:0005737 [Term] id: GO:0044445 name: obsolete cytosolic part namespace: cellular_component def: "OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cytosol component" EXACT [] is_obsolete: true consider: GO:0005829 [Term] id: GO:0044446 name: obsolete intracellular organelle part namespace: cellular_component def: "OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0043229 [Term] id: GO:0044447 name: obsolete axoneme part namespace: cellular_component def: "OBSOLETE. Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:cilia, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. subset: gocheck_do_not_annotate synonym: "axonemal part" EXACT [] is_obsolete: true consider: GO:0005930 [Term] id: GO:0044448 name: obsolete cell cortex part namespace: cellular_component def: "OBSOLETE. Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005938 [Term] id: GO:0044449 name: obsolete contractile fiber part namespace: cellular_component def: "OBSOLETE. Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "contractile fibre component" EXACT [] synonym: "muscle fiber component" BROAD [] synonym: "muscle fibre component" BROAD [] is_obsolete: true consider: GO:0043292 [Term] id: GO:0044450 name: obsolete microtubule organizing center part namespace: cellular_component def: "OBSOLETE. Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "microtubule organizing centre component" EXACT [] synonym: "MTOC component" EXACT [] is_obsolete: true consider: GO:0005815 [Term] id: GO:0044451 name: obsolete nucleoplasm part namespace: cellular_component def: "OBSOLETE. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005654 [Term] id: GO:0044452 name: obsolete nucleolar part namespace: cellular_component def: "OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "nucleolus component" EXACT [] is_obsolete: true consider: GO:0005730 [Term] id: GO:0044453 name: obsolete nuclear membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0031965 [Term] id: GO:0044454 name: obsolete nuclear chromosome part namespace: cellular_component def: "OBSOLETE. Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0000228 [Term] id: GO:0044455 name: obsolete mitochondrial membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0031966 [Term] id: GO:0044456 name: obsolete synapse part namespace: cellular_component def: "OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "synaptic component" RELATED [NIF_Subcellular:sao1784069613] xref: NIF_Subcellular:sao1784069613 is_obsolete: true consider: GO:0045202 [Term] id: GO:0044457 name: obsolete cell septum part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0030428 [Term] id: GO:0044458 name: motile cilium assembly namespace: biological_process alt_id: GO:1903887 def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf] synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "motile primary cilium assembly" RELATED [] synonym: "motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0060271 ! cilium assembly created_by: krc creation_date: 2015-02-06T17:23:23Z [Term] id: GO:0044459 name: obsolete plasma membrane part namespace: cellular_component def: "OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0005886 [Term] id: GO:0044460 name: obsolete flagellum part namespace: cellular_component def: "OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum part ; GO:0044461'. synonym: "flagellum component" EXACT [] synonym: "flagellum part" EXACT [] is_obsolete: true [Term] id: GO:0044461 name: obsolete bacterial-type flagellum part namespace: cellular_component def: "OBSOLETE. Any constituent part of the bacterial-type flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by a transmembrane ion potential, typically a proton or sodium potential." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, GOC:jl, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:25251856] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "flagellin-based flagellum part" EXACT [] is_obsolete: true consider: GO:0009288 [Term] id: GO:0044462 name: obsolete external encapsulating structure part namespace: cellular_component def: "OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0030312 [Term] id: GO:0044463 name: obsolete cell projection part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0042995 [Term] id: GO:0044464 name: obsolete cell part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] synonym: "protoplast" RELATED [GOC:mah] xref: NIF_Subcellular:sao628508602 is_obsolete: true consider: CL:0000000 [Term] id: GO:0044465 name: modulation of sensory perception of pain in other organism namespace: biological_process def: "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism." [GOC:ed, PMID:18579526] synonym: "regulation of sensory perception of pain in another organism" EXACT [] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:0051930 ! regulation of sensory perception of pain created_by: janelomax creation_date: 2012-01-12T03:14:19Z [Term] id: GO:0044466 name: glutaryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203] synonym: "glutaryl-CoA thioesterase activity" EXACT [] xref: EC:1.3.8.6 xref: RHEA:13389 is_a: GO:0047617 ! acyl-CoA hydrolase activity created_by: janelomax creation_date: 2012-01-17T04:16:43Z [Term] id: GO:0044467 name: glial cell-derived neurotrophic factor secretion namespace: biological_process def: "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307] synonym: "GDNF secretion" EXACT [] synonym: "glial cell line-derived neurotrophic factor secretion" RELATED [] is_a: GO:0050663 ! cytokine secretion created_by: janelomax creation_date: 2012-01-17T04:26:05Z [Term] id: GO:0044468 name: envenomation resulting in modulation of blood coagulation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] synonym: "envenomation resulting in regulation of blood coagulation in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0035806 ! modulation of blood coagulation in other organism relationship: has_part GO:0035806 ! modulation of blood coagulation in other organism created_by: janelomax creation_date: 2012-01-19T01:24:10Z [Term] id: GO:0044469 name: envenomation resulting in positive regulation of blood coagulation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism relationship: has_part GO:0035807 ! positive regulation of blood coagulation in other organism created_by: janelomax creation_date: 2012-01-19T01:29:09Z [Term] id: GO:0044470 name: envenomation resulting in negative regulation of blood coagulation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in other organism is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism relationship: has_part GO:0035899 ! negative regulation of blood coagulation in other organism created_by: janelomax creation_date: 2012-01-19T01:32:48Z [Term] id: GO:0044471 name: envenomation resulting in pore formation in membrane of other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0035915 ! pore formation in membrane of other organism created_by: janelomax creation_date: 2012-01-19T01:39:47Z [Term] id: GO:0044472 name: envenomation resulting in modulation of calcium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism relationship: has_part GO:0035916 ! modulation of calcium channel activity in other organism created_by: janelomax creation_date: 2012-01-19T02:17:25Z [Term] id: GO:0044473 name: envenomation resulting in negative regulation of calcium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] is_a: GO:0044472 ! envenomation resulting in modulation of calcium channel activity in other organism relationship: has_part GO:0035917 ! negative regulation of calcium channel activity in other organism created_by: janelomax creation_date: 2012-01-19T02:19:46Z [Term] id: GO:0044474 name: envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] is_a: GO:0044473 ! envenomation resulting in negative regulation of calcium channel activity in other organism relationship: has_part GO:0035918 ! negative regulation of voltage-gated calcium channel activity in other organism created_by: janelomax creation_date: 2012-01-19T02:25:04Z [Term] id: GO:0044475 name: envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism relationship: has_part GO:0035920 ! negative regulation of high voltage-gated calcium channel activity in other organism created_by: janelomax creation_date: 2012-01-19T02:28:11Z [Term] id: GO:0044476 name: envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism relationship: has_part GO:0035919 ! negative regulation of low voltage-gated calcium channel activity in other organism created_by: janelomax creation_date: 2012-01-19T02:28:42Z [Term] id: GO:0044477 name: envenomation resulting in negative regulation of platelet aggregation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0035893 ! negative regulation of platelet aggregation in other organism relationship: has_part GO:0035893 ! negative regulation of platelet aggregation in other organism created_by: janelomax creation_date: 2012-01-19T02:36:44Z [Term] id: GO:0044478 name: envenomation resulting in positive regulation of platelet aggregation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in other organism is_a: GO:0044469 ! envenomation resulting in positive regulation of blood coagulation in other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0035894 ! positive regulation of platelet aggregation in other organism relationship: has_part GO:0035894 ! positive regulation of platelet aggregation in other organism created_by: janelomax creation_date: 2012-01-19T02:39:45Z [Term] id: GO:0044479 name: envenomation resulting in modulation of mast cell degranulation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0035895 ! modulation of mast cell degranulation in other organism created_by: janelomax creation_date: 2012-01-19T02:51:51Z [Term] id: GO:0044480 name: envenomation resulting in positive regulation of mast cell degranulation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] is_a: GO:0044479 ! envenomation resulting in modulation of mast cell degranulation in other organism relationship: has_part GO:0035896 ! positive regulation of mast cell degranulation in other organism created_by: janelomax creation_date: 2012-01-19T02:54:37Z [Term] id: GO:0044481 name: envenomation resulting in proteolysis in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism." [GOC:fj, GOC:jl, PMID:15922779] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0035897 ! proteolysis in other organism created_by: janelomax creation_date: 2012-01-19T03:01:16Z [Term] id: GO:0044482 name: envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism." [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419] synonym: "envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism" EXACT [] is_a: GO:0044358 ! envenomation resulting in hemorrhagic damage to other organism created_by: janelomax creation_date: 2012-01-19T03:12:04Z [Term] id: GO:0044483 name: envenomation resulting in impairment of hemostasis in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in negative regulation of hemostasis in other organism" EXACT [] synonym: "envenomation, impairing hemostasis in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism created_by: janelomax creation_date: 2012-01-19T03:15:56Z [Term] id: GO:0044484 name: envenomation resulting in fibrinolysis in other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404] is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0042730 ! fibrinolysis relationship: has_part GO:0042730 ! fibrinolysis created_by: janelomax creation_date: 2012-01-26T03:26:33Z [Term] id: GO:0044485 name: envenomation resulting in fibrinogenolysis in other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404] is_a: GO:0044536 ! envenomation resulting in depletion of circulating fibrinogen in other organism created_by: janelomax creation_date: 2012-01-26T03:41:01Z [Term] id: GO:0044486 name: modulation of transmission of nerve impulse in other organism namespace: biological_process def: "The process in which an organism effects a change in the transmission of a nerve impulse in another organism." [GOC:jl] synonym: "modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph] synonym: "regulation of transmission of nerve impulse in other organism" EXACT [] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:0051969 ! regulation of transmission of nerve impulse created_by: janelomax creation_date: 2012-01-26T04:03:31Z [Term] id: GO:0044487 name: envenomation resulting in modulation of transmission of nerve impulse in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044486 ! modulation of transmission of nerve impulse in other organism created_by: janelomax creation_date: 2012-01-26T05:01:54Z [Term] id: GO:0044488 name: modulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044561 ! modulation of ion channel activity in other organism created_by: janelomax creation_date: 2012-02-01T11:48:25Z [Term] id: GO:0044489 name: negative regulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044362 ! negative regulation of molecular function in other organism is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism created_by: janelomax creation_date: 2012-02-01T12:21:02Z [Term] id: GO:0044490 name: positive regulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism is_a: GO:0044491 ! positive regulation of molecular function in other organism created_by: janelomax creation_date: 2012-02-01T12:21:26Z [Term] id: GO:0044491 name: positive regulation of molecular function in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0044359 ! modulation of molecular function in other organism created_by: janelomax creation_date: 2012-02-01T12:21:51Z [Term] id: GO:0044492 name: envenomation resulting in modulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism relationship: has_part GO:0044488 ! modulation of voltage-gated sodium channel activity in other organism created_by: janelomax creation_date: 2012-02-01T01:23:04Z [Term] id: GO:0044493 name: envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in other organism relationship: has_part GO:0044489 ! negative regulation of voltage-gated sodium channel activity in other organism created_by: janelomax creation_date: 2012-02-01T01:26:59Z [Term] id: GO:0044494 name: envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in other organism relationship: has_part GO:0044490 ! positive regulation of voltage-gated sodium channel activity in other organism created_by: janelomax creation_date: 2012-02-01T01:29:25Z [Term] id: GO:0044495 name: modulation of blood pressure in other organism namespace: biological_process def: "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] synonym: "regulation of blood pressure in other organism" EXACT [] is_a: GO:0008217 ! regulation of blood pressure created_by: janelomax creation_date: 2012-02-01T02:10:15Z [Term] id: GO:0044496 name: negative regulation of blood pressure in other organism namespace: biological_process def: "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] is_a: GO:0044495 ! modulation of blood pressure in other organism is_a: GO:0045776 ! negative regulation of blood pressure created_by: janelomax creation_date: 2012-02-01T02:15:28Z [Term] id: GO:0044497 name: positive regulation of blood pressure in other organism namespace: biological_process def: "A process by which one organism increases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] is_a: GO:0044495 ! modulation of blood pressure in other organism is_a: GO:0045777 ! positive regulation of blood pressure created_by: janelomax creation_date: 2012-02-01T02:17:21Z [Term] id: GO:0044498 name: envenomation resulting in modulation of blood pressure in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] synonym: "envenomation resulting in regulation of blood pressure in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0044495 ! modulation of blood pressure in other organism relationship: has_part GO:0044495 ! modulation of blood pressure in other organism created_by: janelomax creation_date: 2012-02-01T02:21:27Z [Term] id: GO:0044499 name: envenomation resulting in positive regulation of blood pressure in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in other organism relationship: has_part GO:0044497 ! positive regulation of blood pressure in other organism created_by: janelomax creation_date: 2012-02-01T02:39:06Z [Term] id: GO:0044500 name: envenomation resulting in negative regulation of blood pressure in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] synonym: "hypotensive activity in other organism" EXACT [] is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in other organism relationship: has_part GO:0044496 ! negative regulation of blood pressure in other organism created_by: janelomax creation_date: 2012-02-01T02:40:50Z [Term] id: GO:0044501 name: modulation of signal transduction in other organism namespace: biological_process def: "The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl] is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: janelomax creation_date: 2012-02-23T03:48:19Z [Term] id: GO:0044503 name: modulation of G protein-coupled receptor activity in other organism namespace: biological_process def: "The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] synonym: "modulation of G-protein coupled receptor activity in other organism" EXACT [] is_a: GO:0044504 ! modulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-23T04:20:07Z [Term] id: GO:0044504 name: modulation of receptor activity in other organism namespace: biological_process def: "The process in which an organism effects a change in the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044359 ! modulation of molecular function in other organism created_by: janelomax creation_date: 2012-02-23T04:21:41Z [Term] id: GO:0044505 name: positive regulation of G protein-coupled receptor activity in other organism namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] synonym: "positive regulation of G-protein coupled receptor activity in other organism" EXACT [] synonym: "regulation of G-protein coupled receptor activity in other organism" EXACT [] is_a: GO:0044503 ! modulation of G protein-coupled receptor activity in other organism is_a: GO:0044507 ! positive regulation of receptor activity in other organism is_a: GO:2000273 ! positive regulation of signaling receptor activity created_by: janelomax creation_date: 2012-02-23T04:24:17Z [Term] id: GO:0044506 name: modulation of glucagon-like peptide receptor 1 activity in other organism namespace: biological_process def: "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712] synonym: "regulation of glucagon-like peptide receptor activity in other organism" EXACT [] is_a: GO:0044504 ! modulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-23T04:29:14Z [Term] id: GO:0044507 name: positive regulation of receptor activity in other organism namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044491 ! positive regulation of molecular function in other organism is_a: GO:0044504 ! modulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-23T04:31:52Z [Term] id: GO:0044508 name: glucagon-like peptide 1 receptor activity namespace: molecular_function def: "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein." [GOC:jl, PMID:12529935] is_a: GO:0008528 ! G protein-coupled peptide receptor activity created_by: janelomax creation_date: 2012-02-23T04:50:25Z [Term] id: GO:0044509 name: envenomation resulting in modulation of signal transduction in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044501 ! modulation of signal transduction in other organism created_by: janelomax creation_date: 2012-02-23T04:58:10Z [Term] id: GO:0044510 name: envenomation resulting in positive regulation of signal transduction in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044509 ! envenomation resulting in modulation of signal transduction in other organism relationship: has_part GO:0052028 ! induction by symbiont of host signal transduction pathway created_by: janelomax creation_date: 2012-02-23T05:03:22Z [Term] id: GO:0044511 name: envenomation resulting in modulation of receptor activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044504 ! modulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T10:12:24Z [Term] id: GO:0044512 name: envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism relationship: has_part GO:0044506 ! modulation of glucagon-like peptide receptor 1 activity in other organism created_by: janelomax creation_date: 2012-02-26T10:20:19Z [Term] id: GO:0044513 name: envenomation resulting in modulation of G protein-coupled receptor activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] synonym: "envenomation resulting in modulation of G-protein coupled receptor activity in other organism" EXACT [] is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism relationship: has_part GO:0044503 ! modulation of G protein-coupled receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:02:17Z [Term] id: GO:0044514 name: envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] synonym: "envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism" EXACT [] is_a: GO:0044513 ! envenomation resulting in modulation of G protein-coupled receptor activity in other organism relationship: has_part GO:0044505 ! positive regulation of G protein-coupled receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:06:15Z [Term] id: GO:0044515 name: envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044512 ! envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism relationship: has_part GO:0044516 ! positive regulation of glucagon-like peptide receptor 1 activity in other organism created_by: janelomax creation_date: 2012-02-26T11:08:08Z [Term] id: GO:0044516 name: positive regulation of glucagon-like peptide receptor 1 activity in other organism namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712] is_a: GO:0044506 ! modulation of glucagon-like peptide receptor 1 activity in other organism is_a: GO:0044507 ! positive regulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:09:44Z [Term] id: GO:0044517 name: modulation of vasoactive intestinal polypeptide receptor activity in other organism namespace: biological_process def: "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl] synonym: "modulation of VIP receptor activity in other organism" EXACT [] synonym: "regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] is_a: GO:0044504 ! modulation of receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:48:32Z [Term] id: GO:0044518 name: positive regulation of vasoactive intestinal polypeptide receptor activity in other organism namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl] synonym: "positive regulation of VIP receptor activity in other organism" EXACT [] is_a: GO:0044507 ! positive regulation of receptor activity in other organism is_a: GO:0044517 ! modulation of vasoactive intestinal polypeptide receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:50:34Z [Term] id: GO:0044519 name: envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in modulation of VIP receptor activity in other organism" EXACT [] synonym: "envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] synonym: "envenomation resulting in regulation of VIP receptor activity in other organism" EXACT [] is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in other organism relationship: has_part GO:0044517 ! modulation of vasoactive intestinal polypeptide receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:53:33Z [Term] id: GO:0044520 name: envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in positive regulation of VIP receptor activity in other organism" EXACT [] is_a: GO:0044519 ! envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism relationship: has_part GO:0044518 ! positive regulation of vasoactive intestinal polypeptide receptor activity in other organism created_by: janelomax creation_date: 2012-02-26T11:55:46Z [Term] id: GO:0044521 name: envenomation resulting in muscle damage in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism created_by: janelomax creation_date: 2012-02-27T12:31:08Z [Term] id: GO:0044522 name: envenomation resulting in myocyte killing in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] synonym: "envenomation resulting in myocyte killing causing muscle damage in other organism" EXACT [] is_a: GO:0044521 ! envenomation resulting in muscle damage in other organism created_by: janelomax creation_date: 2012-02-27T12:33:57Z [Term] id: GO:0044523 name: envenomation resulting in damage of muscle extracellular matrix in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] synonym: "envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism" EXACT [] is_a: GO:0044521 ! envenomation resulting in muscle damage in other organism created_by: janelomax creation_date: 2012-02-27T12:40:32Z [Term] id: GO:0044524 name: protein sulfhydration namespace: biological_process def: "The modification of a protein amino acid by the addition of sulfur." [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529] is_a: GO:0006464 ! cellular protein modification process created_by: janelomax creation_date: 2012-03-15T09:39:33Z [Term] id: GO:0044525 name: peptidyl-cystine sulfhydration namespace: biological_process def: "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] is_a: GO:0044524 ! protein sulfhydration created_by: janelomax creation_date: 2012-03-15T09:44:07Z [Term] id: GO:0044526 name: formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine namespace: biological_process def: "The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] is_a: GO:0044525 ! peptidyl-cystine sulfhydration created_by: janelomax creation_date: 2012-03-15T09:45:19Z [Term] id: GO:0044527 name: formation of peptidyl-cystine persulfide by sulphur transfer from H2S namespace: biological_process def: "The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] is_a: GO:0044525 ! peptidyl-cystine sulfhydration created_by: janelomax creation_date: 2012-03-15T09:46:23Z [Term] id: GO:0044528 name: regulation of mitochondrial mRNA stability namespace: biological_process def: "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl] is_a: GO:0043488 ! regulation of mRNA stability created_by: janelomax creation_date: 2012-03-15T03:20:10Z [Term] id: GO:0044529 name: regulation of mitochondrial rRNA stability namespace: biological_process def: "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs." [GOC:al, GOC:jl] is_a: GO:0044357 ! regulation of rRNA stability created_by: janelomax creation_date: 2012-03-15T03:22:19Z [Term] id: GO:0044530 name: supraspliceosomal complex namespace: cellular_component def: "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing." [GOC:ans, GOC:jl, PMID:19282290] synonym: "supraspliceosome complex" EXACT [] is_a: GO:0005681 ! spliceosomal complex created_by: janelomax creation_date: 2012-03-15T03:33:08Z [Term] id: GO:0044531 name: modulation of programmed cell death in other organism namespace: biological_process def: "A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism." [GOC:jl] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:0043067 ! regulation of programmed cell death created_by: janelomax creation_date: 2012-03-20T04:48:41Z [Term] id: GO:0044532 name: modulation of apoptotic process in other organism namespace: biological_process def: "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl] synonym: "regulation of apoptotic process in other organism" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0044531 ! modulation of programmed cell death in other organism created_by: janelomax creation_date: 2012-03-21T11:17:18Z [Term] id: GO:0044533 name: positive regulation of apoptotic process in other organism namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism." [GOC:jl, PMID:17983639] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0044532 ! modulation of apoptotic process in other organism created_by: janelomax creation_date: 2012-03-21T11:25:24Z [Term] id: GO:0044534 name: envenomation resulting in modulation of apoptotic process in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism." [GOC:fj, GOC:jl, PMID:17983639] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0044532 ! modulation of apoptotic process in other organism relationship: has_part GO:0044532 ! modulation of apoptotic process in other organism created_by: janelomax creation_date: 2012-03-21T11:39:44Z [Term] id: GO:0044535 name: very-long-chain fatty acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [PMID:17458872] synonym: "very long chain fatty-acyl-CoA oxidase activity" EXACT [] synonym: "very-long-chain acyl-CoA oxidase activity" EXACT [] synonym: "VLC fatty-acyl-CoA oxidase activity" EXACT [] xref: EC:1.3.3 is_a: GO:0003997 ! acyl-CoA oxidase activity created_by: janelomax creation_date: 2012-03-21T02:04:42Z [Term] id: GO:0044536 name: envenomation resulting in depletion of circulating fibrinogen in other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in negative regulation of circulating fibrinogen in other organism" EXACT [] is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in other organism is_a: GO:0061754 ! negative regulation of circulating fibrinogen levels created_by: janelomax creation_date: 2012-03-21T02:56:49Z [Term] id: GO:0044537 name: regulation of circulating fibrinogen levels namespace: biological_process def: "Any process that modulates the quantity of fibrinogen circulating in the bloodstream." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality created_by: janelomax creation_date: 2012-03-21T03:15:09Z [Term] id: GO:0044538 name: host cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell." [GOC:jl, PMID:20463076] is_a: GO:0033643 ! host cell part created_by: janelomax creation_date: 2012-03-21T03:26:33Z [Term] id: GO:0044539 name: long-chain fatty acid import into cell namespace: biological_process def: "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:jl, GOC:pm, PMID:22022213] synonym: "long-chain fatty acid import" RELATED [] synonym: "long-chain fatty acid uptake" EXACT [] is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0140354 ! lipid import into cell created_by: janelomax creation_date: 2012-03-21T03:34:04Z [Term] id: GO:0044540 name: L-cystine L-cysteine-lyase (deaminating) namespace: molecular_function def: "Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24927] xref: EC:4.4.1.1 xref: KEGG_REACTION:R02408 xref: RHEA:24927 is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: janelomax creation_date: 2012-03-22T11:33:32Z [Term] id: GO:0044541 name: zymogen activation in other organism namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism." [GOC:fj, GOC:jl] is_a: GO:0031638 ! zymogen activation is_a: GO:0044033 ! multi-organism metabolic process created_by: janelomax creation_date: 2012-03-22T11:39:41Z [Term] id: GO:0044542 name: plasminogen activation in other organism namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism." [GOC:fj, GOC:jl] is_a: GO:0031639 ! plasminogen activation is_a: GO:0044541 ! zymogen activation in other organism created_by: janelomax creation_date: 2012-03-22T11:40:03Z [Term] id: GO:0044543 name: envenomation resulting in zymogen activation in other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form." [GOC:fj, GOC:jl] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044541 ! zymogen activation in other organism created_by: janelomax creation_date: 2012-03-22T11:52:56Z [Term] id: GO:0044544 name: envenomation resulting in plasminogen activation in other organism namespace: biological_process def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [GOC:fj, GOC:jl] is_a: GO:0044484 ! envenomation resulting in fibrinolysis in other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0042730 ! fibrinolysis intersection_of: has_part GO:0044542 ! plasminogen activation in other organism relationship: has_part GO:0044542 ! plasminogen activation in other organism created_by: janelomax creation_date: 2012-03-22T11:54:49Z [Term] id: GO:0044545 name: NSL complex namespace: cellular_component def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] synonym: "non-specific lethal complex" EXACT [] is_a: GO:1902562 ! H4 histone acetyltransferase complex created_by: janelomax creation_date: 2012-03-22T12:49:18Z [Term] id: GO:0044546 name: NLRP3 inflammasome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell." [GOC:jl, PMID:21048113] synonym: "NALP3 inflammasome complex assembly" EXACT [] synonym: "NLRP3 inflammasome activation" RELATED [] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: janelomax creation_date: 2012-03-22T01:27:21Z [Term] id: GO:0044547 name: DNA topoisomerase binding namespace: molecular_function alt_id: GO:0017033 def: "Interacting selectively and non-covalently with a DNA topoisomerase." [GOC:jl] synonym: "DNA topoisomerase I binding" NARROW [] is_a: GO:0019899 ! enzyme binding created_by: janelomax creation_date: 2012-03-22T02:30:37Z [Term] id: GO:0044548 name: S100 protein binding namespace: molecular_function alt_id: GO:0048154 alt_id: GO:0048155 def: "Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] synonym: "S100 alpha binding" NARROW [] synonym: "S100 beta binding" NARROW [] synonym: "S100 binding" EXACT [] is_a: GO:0005515 ! protein binding created_by: janelomax creation_date: 2012-03-22T03:23:51Z [Term] id: GO:0044549 name: GTP cyclohydrolase binding namespace: molecular_function alt_id: GO:0043106 def: "Interacting selectively and non-covalently with a GTP cyclohydrolase." [GOC:jl] synonym: "GTP cyclohydrolase I binding" NARROW [] is_a: GO:0019899 ! enzyme binding created_by: janelomax creation_date: 2012-03-22T04:38:14Z [Term] id: GO:0044550 name: secondary metabolite biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] synonym: "secondary metabolite biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019748 ! secondary metabolic process created_by: janelomax creation_date: 2012-03-29T01:55:18Z [Term] id: GO:0044551 name: envenomation resulting in vasodilation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:21050868] synonym: "envenomation resulting in modulation of vasodilation in other organism" RELATED [] synonym: "envenomation resulting in regulation of vasodilation in other organism" RELATED [] is_a: GO:0044500 ! envenomation resulting in negative regulation of blood pressure in other organism relationship: has_part GO:0044552 ! vasodilation in other organism created_by: janelomax creation_date: 2012-03-29T02:07:45Z [Term] id: GO:0044552 name: vasodilation in other organism namespace: biological_process def: "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism." [GOC:ecd, GOC:jl, PMID:21050868] synonym: "modulation of vasodilation in other organism" RELATED [] synonym: "regulation of vasodilation in other organism" RELATED [] is_a: GO:0042311 ! vasodilation is_a: GO:0044553 ! modulation of biological quality in other organism is_a: GO:0044706 ! multi-multicellular organism process created_by: janelomax creation_date: 2012-03-29T02:14:42Z [Term] id: GO:0044553 name: modulation of biological quality in other organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:jl] synonym: "regulation of biological quality in other organism" EXACT [] is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: janelomax creation_date: 2012-03-29T02:35:03Z [Term] id: GO:0044554 name: modulation of heart rate in other organism namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction of another organism." [GOC:jl, PMID:20923766] synonym: "regulation of heart rate in other organism" EXACT [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0044553 ! modulation of biological quality in other organism created_by: janelomax creation_date: 2012-03-29T02:59:43Z [Term] id: GO:0044555 name: negative regulation of heart rate in other organism namespace: biological_process def: "Any process that stops, prevents or reduces the frequency of heart contraction of another organism." [GOC:ecd, GOC:jl, PMID:20923766] is_a: GO:0010459 ! negative regulation of heart rate is_a: GO:0044554 ! modulation of heart rate in other organism created_by: janelomax creation_date: 2012-03-29T03:01:20Z [Term] id: GO:0044556 name: envenomation resulting in negative regulation of heart rate of other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:20923766] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044555 ! negative regulation of heart rate in other organism created_by: janelomax creation_date: 2012-03-29T03:04:52Z [Term] id: GO:0044557 name: relaxation of smooth muscle namespace: biological_process def: "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:jl] synonym: "smooth muscle relaxation" EXACT [] is_a: GO:0090075 ! relaxation of muscle created_by: janelomax creation_date: 2012-04-05T02:42:28Z [Term] id: GO:0044558 name: uterine smooth muscle relaxation namespace: biological_process def: "A process in which the extent of smooth muscle contraction is reduced in the uterus." [GOC:jl] synonym: "smooth muscle relaxation of the uterus" EXACT [] is_a: GO:0044557 ! relaxation of smooth muscle created_by: janelomax creation_date: 2012-04-05T02:57:11Z [Term] id: GO:0044559 name: envenomation resulting in modulation of voltage-gated potassium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism relationship: has_part GO:0044360 ! modulation of voltage-gated potassium channel activity in other organism created_by: janelomax creation_date: 2012-04-05T03:35:20Z [Term] id: GO:0044560 name: envenomation resulting in modulation of ion channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism." [GOC:fj, GOC:jl] synonym: "envenomation resulting in regulation of ion channel activity in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044561 ! modulation of ion channel activity in other organism created_by: janelomax creation_date: 2012-04-05T03:46:35Z [Term] id: GO:0044561 name: modulation of ion channel activity in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism." [GOC:jl] synonym: "regulation of ion channel activity in other organism" EXACT [] is_a: GO:0044359 ! modulation of molecular function in other organism created_by: janelomax creation_date: 2012-04-05T03:48:28Z [Term] id: GO:0044562 name: envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] is_a: GO:0044559 ! envenomation resulting in modulation of voltage-gated potassium channel activity in other organism relationship: has_part GO:0044361 ! negative regulation of voltage-gated potassium channel activity in other organism created_by: janelomax creation_date: 2012-04-05T04:01:49Z [Term] id: GO:0044563 name: envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] synonym: "voltage-dependence of activation shift (to the left)" EXACT [] is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism created_by: janelomax creation_date: 2012-04-05T04:06:29Z [Term] id: GO:0044564 name: envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism." [GOC:fj, GOC:jl] is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism created_by: janelomax creation_date: 2012-04-05T04:14:24Z [Term] id: GO:0044565 name: dendritic cell proliferation namespace: biological_process def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816] is_a: GO:0046651 ! lymphocyte proliferation created_by: janelomax creation_date: 2012-04-05T04:31:39Z [Term] id: GO:0044566 name: chondrocyte activation namespace: biological_process def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl] is_a: GO:0001775 ! cell activation created_by: janelomax creation_date: 2012-04-05T04:45:38Z [Term] id: GO:0044567 name: primary cell wall cellulose synthase complex namespace: cellular_component def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein." [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367] synonym: "primary cell wall CESA complex" EXACT [] synonym: "primary cell-wall cellulose synthase complex" EXACT [] is_a: GO:0010330 ! cellulose synthase complex created_by: janelomax creation_date: 2012-04-18T12:24:16Z [Term] id: GO:0044568 name: secondary cell wall cellulose synthase complex namespace: cellular_component def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4." [GOC:mengo_curators, GOC:tt, PMID:21307367] synonym: "secondary cell wall CESA complex" EXACT [] synonym: "secondary cell wall CesA complex" EXACT [] synonym: "secondary cell-wall cellulose synthase complex" EXACT [] is_a: GO:0010330 ! cellulose synthase complex created_by: janelomax creation_date: 2012-04-18T12:55:04Z [Term] id: GO:0044569 name: [Ni-Fe] hydrogenase complex namespace: cellular_component def: "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer." [GOC:mengo_curators, GOC:tt, PMID:8936309] synonym: "Ni-Fe hydrogenase complex" EXACT [] synonym: "nickel-iron hydrogenase complex" EXACT [] is_a: GO:1902494 ! catalytic complex created_by: janelomax creation_date: 2012-04-18T01:26:35Z [Term] id: GO:0044570 name: starch utilization system complex namespace: cellular_component def: "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch." [GOC:mengo_curators, GOC:tt, PMID:19553672] synonym: "Sus complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009279 ! cell outer membrane created_by: janelomax creation_date: 2012-04-18T02:46:24Z [Term] id: GO:0044571 name: [2Fe-2S] cluster assembly namespace: biological_process def: "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888] synonym: "2Fe-2S cluster assembly" EXACT [] synonym: "[2Fe-2S] cluster biosynthetic process" RELATED [] is_a: GO:0016226 ! iron-sulfur cluster assembly created_by: janelomax creation_date: 2012-04-18T03:06:30Z [Term] id: GO:0044572 name: [4Fe-4S] cluster assembly namespace: biological_process def: "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888] synonym: "4Fe-4S cluster assembly" EXACT [] synonym: "[4Fe-4S] cluster biosynthetic process" RELATED [] is_a: GO:0016226 ! iron-sulfur cluster assembly created_by: janelomax creation_date: 2012-04-18T03:19:23Z [Term] id: GO:0044573 name: nitrogenase P cluster assembly namespace: biological_process def: "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide." [PMID:17563349] synonym: "nitrogenase P cluster biosynthesis" EXACT [] synonym: "nitrogenase P cluster maturation" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly created_by: janelomax creation_date: 2012-04-18T03:29:04Z [Term] id: GO:0044574 name: starch utilization system complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452] synonym: "assembly of starch utilization system complex" EXACT [] synonym: "SUS complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly created_by: janelomax creation_date: 2012-04-19T03:40:24Z [Term] id: GO:0044575 name: cellulosome assembly namespace: biological_process def: "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall." [GOC:mengo_curators, GOC:tt, PMID:20373916] is_a: GO:0070925 ! organelle assembly created_by: janelomax creation_date: 2012-04-19T03:42:36Z [Term] id: GO:0044576 name: pentose catabolic process to ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt] synonym: "pentose catabolism to ethanol" EXACT [] is_a: GO:0006115 ! ethanol biosynthetic process is_a: GO:0019323 ! pentose catabolic process created_by: janelomax creation_date: 2012-04-19T03:46:37Z [Term] id: GO:0044577 name: xylose catabolic process to ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt] synonym: "xylose catabolism to ethanol" EXACT [] is_a: GO:0042843 ! D-xylose catabolic process is_a: GO:0044576 ! pentose catabolic process to ethanol created_by: janelomax creation_date: 2012-04-19T03:50:46Z [Term] id: GO:0044578 name: butyryl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA." [GOC:jl] synonym: "butyryl-CoA biosynthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process created_by: janelomax creation_date: 2012-04-19T04:23:26Z [Term] id: GO:0044579 name: butyryl-CoA biosynthetic process from acetyl-CoA namespace: biological_process def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA." [GOC:mengo_curators, GOC:tt, PMID:19539744] synonym: "butyryl-CoA biosynthesis from acetyl-CoA" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0044578 ! butyryl-CoA biosynthetic process created_by: janelomax creation_date: 2012-04-19T04:25:07Z [Term] id: GO:0044580 name: butyryl-CoA catabolic process namespace: biological_process def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA." [GOC:jl] synonym: "butyryl-CoA catabolism" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0036115 ! fatty-acyl-CoA catabolic process created_by: janelomax creation_date: 2012-04-19T04:28:46Z [Term] id: GO:0044581 name: butyryl-CoA catabolic process to butyrate namespace: biological_process def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate." [GOC:mengo_curators, GOC:tt, PMID:19539744] synonym: "butyryl-CoA catabolism to butyrate" EXACT [] is_a: GO:0044580 ! butyryl-CoA catabolic process is_a: GO:0046358 ! butyrate biosynthetic process created_by: janelomax creation_date: 2012-04-19T04:29:40Z [Term] id: GO:0044582 name: butyryl-CoA catabolic process to butanol namespace: biological_process def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol." [GOC:mengo_curators, GOC:tt, PMID:19539744] synonym: "butyryl-CoA catabolism to butanol" EXACT [] is_a: GO:0044580 ! butyryl-CoA catabolic process is_a: GO:0071271 ! 1-butanol biosynthetic process created_by: janelomax creation_date: 2012-04-19T04:40:06Z [Term] id: GO:0044583 name: cellotriose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellotriose." [GOC:mengo_curators, GOC:tt] is_a: GO:0048031 ! trisaccharide binding created_by: janelomax creation_date: 2012-04-24T04:48:01Z [Term] id: GO:0044584 name: cellodextrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellodextrin, a glucose polymer of 2 or more glucose monomers." [GOC:mengo_curators, GOC:tt, PMID:18952792] is_a: GO:0030247 ! polysaccharide binding is_a: GO:0070492 ! oligosaccharide binding created_by: janelomax creation_date: 2012-04-24T04:52:05Z [Term] id: GO:0044585 name: cellobiose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellobiose, a disaccharide that represents the basic repeating unit of cellulose." [GOC:mengo_curators, GOC:tt] is_a: GO:0048030 ! disaccharide binding created_by: janelomax creation_date: 2012-04-24T04:55:10Z [Term] id: GO:0044586 name: cellotetraose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt] is_a: GO:0070492 ! oligosaccharide binding created_by: janelomax creation_date: 2012-04-24T04:56:10Z [Term] id: GO:0044587 name: cellopentaose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt] is_a: GO:0070492 ! oligosaccharide binding created_by: janelomax creation_date: 2012-04-24T04:57:01Z [Term] id: GO:0044588 name: laminaribiose binding namespace: molecular_function def: "Interacting selectively and non-covalently with laminaribiose, a disaccharide." [GOC:mengo_curators, GOC:tt] is_a: GO:0070492 ! oligosaccharide binding created_by: janelomax creation_date: 2012-04-26T01:19:40Z [Term] id: GO:0044589 name: pectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with pectin." [GOC:mengo_curators, GOC:tt] is_a: GO:0008144 ! drug binding is_a: GO:0048028 ! galacturonan binding created_by: janelomax creation_date: 2012-04-26T01:26:56Z [Term] id: GO:0044590 name: iron-sulfur-molybdenum cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691] synonym: "FeMo co binding" EXACT [] synonym: "FeMoco binding" EXACT [] is_a: GO:0048037 ! cofactor binding created_by: janelomax creation_date: 2012-04-26T02:27:39Z [Term] id: GO:0044591 name: response to amylopectin namespace: biological_process def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus." [GOC:mengo_curators, GOC:tt] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: janelomax creation_date: 2012-04-26T03:20:03Z [Term] id: GO:0044592 name: response to pullulan namespace: biological_process def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus." [GOC:mengo_curators, GOC:tt] is_a: GO:0009743 ! response to carbohydrate created_by: janelomax creation_date: 2012-04-26T03:59:06Z [Term] id: GO:0044593 name: iron-sulfur-molybdenum cofactor assembly namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691] synonym: "FeMoco assembly" EXACT [] synonym: "FeMoco biosynthetic process" EXACT [] synonym: "iron molybdenum cofactor assembly" EXACT [] synonym: "iron molybdenum cofactor biosynthesis" EXACT [] synonym: "iron molybdenum cofactor biosynthetic process" EXACT [] is_a: GO:0051188 ! cofactor biosynthetic process created_by: janelomax creation_date: 2012-04-26T04:01:53Z [Term] id: GO:0044594 name: 17-beta-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+." [PMID:17074428] xref: RHEA:24612 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: janelomax creation_date: 2012-04-26T04:49:13Z [Term] id: GO:0044595 name: decaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate." [PMID:10777520] xref: MetaCyc:RXN-9282 xref: Reactome:R-HSA-2162193 "DHDB is methylated to MHDB by COQ3" xref: RHEA:44492 is_a: GO:0010420 ! 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity created_by: janelomax creation_date: 2012-04-26T04:52:05Z [Term] id: GO:0044596 name: 3-demethylubiquinone-10 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-10 = S-adenosyl-L-homocysteine + ubiquinone-10." [PMID:10777520] xref: MetaCyc:RXN-9237 xref: Reactome:R-HSA-2162186 "DeMQ10H2 is methylated to Q10H2 by COQ3" is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity created_by: janelomax creation_date: 2012-04-26T04:54:11Z [Term] id: GO:0044597 name: daunorubicin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer." [PMID:20837989] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: janelomax creation_date: 2012-05-01T03:09:51Z [Term] id: GO:0044598 name: doxorubicin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy." [PMID:10200167] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901661 ! quinone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: janelomax creation_date: 2012-05-01T03:30:21Z [Term] id: GO:0044599 name: AP-5 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230] synonym: "adaptor protein-5 adaptor complex" EXACT [] is_a: GO:0030119 ! AP-type membrane coat adaptor complex created_by: janelomax creation_date: 2012-05-01T03:48:11Z [Term] id: GO:0044600 name: protein guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins." [GOC:sp, PMID:20651120] is_a: GO:0070568 ! guanylyltransferase activity relationship: part_of GO:0018260 ! protein guanylylation created_by: janelomax creation_date: 2012-05-01T04:00:34Z [Term] id: GO:0044601 name: protein denucleotidylation namespace: biological_process def: "The removal of a nucleotide from a protein amino acid." [GOC:sp, PMID:21734656] is_a: GO:0006464 ! cellular protein modification process created_by: janelomax creation_date: 2012-05-01T04:13:54Z [Term] id: GO:0044602 name: protein deadenylylation namespace: biological_process def: "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656] synonym: "protein deAMPylation" EXACT [PMID:21734656] is_a: GO:0044601 ! protein denucleotidylation created_by: janelomax creation_date: 2012-05-01T04:16:22Z [Term] id: GO:0044603 name: protein adenylylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656] synonym: "protein deAMPylase activity" EXACT [PMID:21734656] synonym: "protein deAMPylation activity" EXACT [PMID:21734656] is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0018117 ! protein adenylylation relationship: part_of GO:0044602 ! protein deadenylylation created_by: janelomax creation_date: 2012-05-01T04:18:07Z [Term] id: GO:0044604 name: ATPase-coupled phytochelatin transmembrane transporter activity namespace: molecular_function alt_id: GO:0071991 alt_id: GO:0071992 def: "Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] comment: Merge phytochelatin transporter activity and phytochelatin transmembrane transporter activity as per https://github.com/geneontology/go-ontology/issues/14492 synonym: "ATP-dependent phytochelatin transmembrane transporter activity" EXACT [] synonym: "cadystin transmembrane transporter activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "cadystin transmembrane transporter ATPase activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "cadystin transporter activity" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "phytochelatin transmembrane transporter activity" RELATED [] synonym: "phytochelatin transmembrane transporter ATPase activity" EXACT [] synonym: "phytochelatin transporter activity" RELATED [] is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity relationship: part_of GO:0071994 ! phytochelatin transmembrane transport created_by: janelomax creation_date: 2010-10-25T01:00:17Z [Term] id: GO:0044605 name: phosphocholine transferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate." [GOC:sp, PMID:21822290] is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: janelomax creation_date: 2012-05-24T04:44:25Z [Term] id: GO:0044606 name: phosphocholine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate." [GOC:sp, PMID:22158903] is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides created_by: janelomax creation_date: 2012-05-24T04:46:44Z [Term] id: GO:0044607 name: disruption by symbiont of host endothelial cells namespace: biological_process def: "Any process in which an organism has a negative effect on the functioning of the host's endothelial cells." [GOC:jl] is_a: GO:0044004 ! disruption by symbiont of host cell created_by: janelomax creation_date: 2012-05-30T02:24:50Z [Term] id: GO:0044608 name: peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine namespace: biological_process def: "The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester." [RESID:AA0507] synonym: "peptidyl-threonine esterification" EXACT [] xref: RESID:AA0507 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018350 ! protein esterification created_by: janelomax creation_date: 2012-05-30T02:47:57Z [Term] id: GO:0044609 name: DBIRD complex namespace: cellular_component def: "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD." [GOC:sp, PMID:22446626] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: janelomax creation_date: 2012-05-30T03:04:23Z [Term] id: GO:0044610 name: FMN transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other." [GOC:ans, PMID:22185573] synonym: "flavine mononucleotide transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity created_by: janelomax creation_date: 2012-05-30T03:09:19Z [Term] id: GO:0044611 name: nuclear pore inner ring namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "Nup170 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: janelomax creation_date: 2012-06-20T01:14:17Z [Term] id: GO:0044612 name: nuclear pore linkers namespace: cellular_component def: "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "Nic96 complex" RELATED [] synonym: "Nup82 complex" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: janelomax creation_date: 2012-06-20T01:22:40Z [Term] id: GO:0044613 name: nuclear pore central transport channel namespace: cellular_component def: "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "karyopherin docking complex" RELATED [] synonym: "nuclear pore central channel" EXACT [] synonym: "nuclear pore central plug" EXACT [] synonym: "nuclear pore transport channel" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: janelomax creation_date: 2012-06-20T01:25:30Z [Term] id: GO:0044614 name: nuclear pore cytoplasmic filaments namespace: cellular_component def: "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "cytoplasmic fibers of the NPC" EXACT [PMID:7775481, PMID:8978815, PMID:9456312] synonym: "cytoplasmic fibers of the nuclear pore complex" EXACT [PMID:7775481, PMID:8978815, PMID:9456312] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: janelomax creation_date: 2012-06-20T01:28:18Z [Term] id: GO:0044615 name: nuclear pore nuclear basket namespace: cellular_component def: "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: janelomax creation_date: 2012-06-20T01:31:01Z [Term] id: GO:0044616 name: modulation of relaxation of muscle in other organism namespace: biological_process def: "The process in which an organism effects a change in the relaxation of muscle in a second organism." [GOC:jl] synonym: "regulation of relaxation of muscle in other organism" EXACT [] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:1901077 ! regulation of relaxation of muscle created_by: janelomax creation_date: 2012-07-04T01:54:12Z [Term] id: GO:0044617 name: modulation of relaxation of smooth muscle in other organism namespace: biological_process def: "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism." [GOC:jl] synonym: "regulation of relaxation of smooth muscle in other organism" EXACT [] is_a: GO:0044616 ! modulation of relaxation of muscle in other organism is_a: GO:1901080 ! regulation of relaxation of smooth muscle created_by: janelomax creation_date: 2012-07-04T01:55:37Z [Term] id: GO:0044618 name: modulation of relaxation of uterine smooth muscle in other organism namespace: biological_process def: "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl] synonym: "regulation of relaxation of uterine smooth muscle in other organism" EXACT [] is_a: GO:0044617 ! modulation of relaxation of smooth muscle in other organism is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation created_by: janelomax creation_date: 2012-07-04T01:56:04Z [Term] id: GO:0044619 name: positive regulation of relaxation of uterine smooth muscle in other organism namespace: biological_process def: "The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism." [GOC:jl] is_a: GO:0044618 ! modulation of relaxation of uterine smooth muscle in other organism is_a: GO:1900721 ! positive regulation of uterine smooth muscle relaxation created_by: janelomax creation_date: 2012-07-04T02:51:26Z [Term] id: GO:0044620 name: ACP phosphopantetheine attachment site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)." [GOC:jl, GOC:vw] is_a: GO:0051192 ! prosthetic group binding created_by: janelomax creation_date: 2012-07-04T03:25:04Z [Term] id: GO:0044621 name: modulation of cell migration in other organism namespace: biological_process def: "The process in which an organism effects a change in the process of cell migration in a second organism." [GOC:jl] synonym: "regulation of cell migration in other organism" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0035821 ! modification of morphology or physiology of other organism created_by: janelomax creation_date: 2012-07-04T04:40:13Z [Term] id: GO:0044622 name: negative regulation of cell migration in other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." [GOC:jl] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0044621 ! modulation of cell migration in other organism created_by: janelomax creation_date: 2012-07-04T04:42:14Z [Term] id: GO:0044623 name: positive regulation of cell migration in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration in a second organism." [GOC:jl] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0044621 ! modulation of cell migration in other organism created_by: janelomax creation_date: 2012-07-04T04:44:59Z [Term] id: GO:0044624 name: envenomation resulting in modulation of cell migration in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] synonym: "envenomation resulting in regulation of cell migration in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0044621 ! modulation of cell migration in other organism relationship: has_part GO:0044621 ! modulation of cell migration in other organism created_by: janelomax creation_date: 2012-07-04T05:03:56Z [Term] id: GO:0044625 name: envenomation resulting in negative regulation of cell migration in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in other organism relationship: has_part GO:0044622 ! negative regulation of cell migration in other organism created_by: janelomax creation_date: 2012-07-04T05:07:16Z [Term] id: GO:0044626 name: envenomation resulting in positive regulation of cell migration in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in other organism relationship: has_part GO:0044623 ! positive regulation of cell migration in other organism created_by: janelomax creation_date: 2012-07-04T05:08:21Z [Term] id: GO:0044627 name: modulation of complement activation, classical pathway in other organism namespace: biological_process def: "A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040] synonym: "regulation of complement activation, classical pathway in other organism" EXACT [] is_a: GO:0030450 ! regulation of complement activation, classical pathway is_a: GO:0044645 ! modulation of complement activation in other organism created_by: janelomax creation_date: 2012-07-05T12:55:53Z [Term] id: GO:0044628 name: positive regulation of complement activation, classical pathway in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0044627 ! modulation of complement activation, classical pathway in other organism is_a: GO:0045960 ! positive regulation of complement activation, classical pathway created_by: janelomax creation_date: 2012-07-05T01:00:10Z [Term] id: GO:0044629 name: negative regulation of complement activation, classical pathway in other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0044627 ! modulation of complement activation, classical pathway in other organism is_a: GO:0045959 ! negative regulation of complement activation, classical pathway created_by: janelomax creation_date: 2012-07-05T01:03:25Z [Term] id: GO:0044630 name: modulation of complement activation, lectin pathway in other organism namespace: biological_process def: "A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040] synonym: "regulation of complement activation, lectin pathway in other organism" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0044645 ! modulation of complement activation in other organism created_by: janelomax creation_date: 2012-07-05T01:10:31Z [Term] id: GO:0044631 name: positive regulation of complement activation, lectin pathway in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0001870 ! positive regulation of complement activation, lectin pathway is_a: GO:0044630 ! modulation of complement activation, lectin pathway in other organism created_by: janelomax creation_date: 2012-07-05T01:17:33Z [Term] id: GO:0044632 name: negative regulation of complement activation, lectin pathway in other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0001869 ! negative regulation of complement activation, lectin pathway is_a: GO:0044630 ! modulation of complement activation, lectin pathway in other organism created_by: janelomax creation_date: 2012-07-05T01:18:43Z [Term] id: GO:0044633 name: modulation of complement activation, alternative pathway in other organism namespace: biological_process def: "A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] synonym: "regulation of complement activation, alternative pathway in other organism" RELATED [] is_a: GO:0030451 ! regulation of complement activation, alternative pathway is_a: GO:0044645 ! modulation of complement activation in other organism created_by: janelomax creation_date: 2012-07-05T04:24:08Z [Term] id: GO:0044634 name: negative regulation of complement activation, alternative pathway in other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0044633 ! modulation of complement activation, alternative pathway in other organism is_a: GO:0045957 ! negative regulation of complement activation, alternative pathway created_by: janelomax creation_date: 2012-07-05T04:32:55Z [Term] id: GO:0044635 name: positive regulation of complement activation, alternative pathway in other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] is_a: GO:0044633 ! modulation of complement activation, alternative pathway in other organism is_a: GO:0045958 ! positive regulation of complement activation, alternative pathway created_by: janelomax creation_date: 2012-07-05T04:36:11Z [Term] id: GO:0044636 name: envenomation resulting in modulation of complement activation, classical pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism relationship: has_part GO:0044627 ! modulation of complement activation, classical pathway in other organism created_by: janelomax creation_date: 2012-07-05T04:40:57Z [Term] id: GO:0044637 name: envenomation resulting in negative regulation of complement activation, classical pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in other organism relationship: has_part GO:0044629 ! negative regulation of complement activation, classical pathway in other organism created_by: janelomax creation_date: 2012-07-05T04:46:56Z [Term] id: GO:0044638 name: envenomation resulting in positive regulation of complement activation, classical pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in other organism relationship: has_part GO:0044628 ! positive regulation of complement activation, classical pathway in other organism created_by: janelomax creation_date: 2012-07-05T04:51:36Z [Term] id: GO:0044639 name: envenomation resulting in modulation of complement activation, lectin pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] synonym: "envenomation resulting in regulation of complement activation, lectin pathway in other organism" EXACT [] is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism relationship: has_part GO:0044630 ! modulation of complement activation, lectin pathway in other organism created_by: janelomax creation_date: 2012-07-05T04:53:36Z [Term] id: GO:0044640 name: envenomation resulting in negative regulation of complement activation, lectin pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in other organism relationship: has_part GO:0044632 ! negative regulation of complement activation, lectin pathway in other organism created_by: janelomax creation_date: 2012-07-05T04:56:30Z [Term] id: GO:0044641 name: envenomation resulting in positive regulation of complement activation, lectin pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in other organism relationship: has_part GO:0044631 ! positive regulation of complement activation, lectin pathway in other organism created_by: janelomax creation_date: 2012-07-11T11:50:23Z [Term] id: GO:0044642 name: envenomation resulting in modulation of complement activation, alternative pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] synonym: "envenomation resulting in regulation of complement activation, alternative pathway in other organism" EXACT [] is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in other organism relationship: has_part GO:0044633 ! modulation of complement activation, alternative pathway in other organism created_by: janelomax creation_date: 2012-07-11T11:53:12Z [Term] id: GO:0044643 name: envenomation resulting in positive regulation of complement activation, alternative pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in other organism relationship: has_part GO:0044635 ! positive regulation of complement activation, alternative pathway in other organism created_by: janelomax creation_date: 2012-07-11T11:56:48Z [Term] id: GO:0044644 name: envenomation resulting in negative regulation of complement activation, alternative pathway in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in other organism relationship: has_part GO:0044634 ! negative regulation of complement activation, alternative pathway in other organism created_by: janelomax creation_date: 2012-07-11T12:35:11Z [Term] id: GO:0044645 name: modulation of complement activation in other organism namespace: biological_process def: "A process that modulates the frequency, rate or extent of complement activation in a different organism." [GOC:fj, GOC:jl, PMID:20837040] synonym: "regulation of complement activation in other organism" EXACT [] is_a: GO:0035821 ! modification of morphology or physiology of other organism is_a: GO:0045088 ! regulation of innate immune response created_by: janelomax creation_date: 2012-07-11T12:37:50Z [Term] id: GO:0044646 name: envenomation resulting in modulation of complement activation in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] synonym: "envenomation resulting in regulation of complement activation in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044645 ! modulation of complement activation in other organism created_by: janelomax creation_date: 2012-07-11T12:49:28Z [Term] id: GO:0044647 name: host-symbiont bicellular tight junction namespace: cellular_component def: "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane." [GOC:jl, PMID:21803641] synonym: "host-parasite tight junction" EXACT [] synonym: "host-pathogen tight junction" EXACT [] is_a: GO:0005923 ! bicellular tight junction created_by: janelomax creation_date: 2012-07-11T12:56:18Z [Term] id: GO:0044648 name: histone H3-K4 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0051568 ! histone H3-K4 methylation created_by: janelomax creation_date: 2012-07-11T01:27:33Z [Term] id: GO:0044649 name: envenomation resulting in cytolysis in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism." [GOC:fj, GOC:jl, PMID:22484288] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism intersection_of: has_part GO:0051715 ! cytolysis in other organism relationship: has_part GO:0051715 ! cytolysis in other organism created_by: janelomax creation_date: 2012-07-11T02:13:38Z [Term] id: GO:0044650 name: adhesion of symbiont to host cell namespace: biological_process def: "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl] is_a: GO:0044406 ! adhesion of symbiont to host created_by: janelomax creation_date: 2012-07-12T12:42:14Z [Term] id: GO:0044651 name: adhesion of symbiont to host epithelial cell namespace: biological_process def: "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176] is_a: GO:0044650 ! adhesion of symbiont to host cell created_by: janelomax creation_date: 2012-07-12T12:47:09Z [Term] id: GO:0044652 name: adhesion of symbiont to host endothelial cell namespace: biological_process def: "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176] is_a: GO:0044650 ! adhesion of symbiont to host cell created_by: janelomax creation_date: 2012-07-12T12:49:07Z [Term] id: GO:0044653 name: dextrin alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: dextrin + H2O = alpha-D-glucose." [PMID:18556189] xref: EC:3.2.1 is_a: GO:0090599 ! alpha-glucosidase activity created_by: janelomax creation_date: 2012-07-23T02:01:12Z [Term] id: GO:0044654 name: starch alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: starch + H2O = alpha-D-glucose." [PMID:18556189] xref: EC:3.2.1 is_a: GO:0090599 ! alpha-glucosidase activity created_by: janelomax creation_date: 2012-07-23T02:08:10Z [Term] id: GO:0044655 name: phagosome reneutralization namespace: biological_process def: "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation." [GOC:rjd, PMID:22008230] synonym: "phagosomal reneutralization" EXACT [] synonym: "phagosome pH elevation" EXACT [] is_a: GO:0051454 ! intracellular pH elevation relationship: part_of GO:0090382 ! phagosome maturation created_by: janelomax creation_date: 2012-07-26T04:21:14Z [Term] id: GO:0044656 name: regulation of post-lysosomal vacuole size namespace: biological_process def: "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:rjd, PMID:22008230] synonym: "regulation of post-lysosome size" EXACT [GOC:dph] is_a: GO:0032535 ! regulation of cellular component size created_by: janelomax creation_date: 2012-07-26T04:30:56Z [Term] id: GO:0044657 name: pore formation in membrane of other organism during symbiotic interaction namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction." [GOC:jl] is_a: GO:0035915 ! pore formation in membrane of other organism is_a: GO:0052025 ! modification by symbiont of host cell membrane created_by: janelomax creation_date: 2012-08-01T13:12:10Z [Term] id: GO:0044658 name: pore formation in membrane of host by symbiont namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism." [GOC:jl] is_a: GO:0044657 ! pore formation in membrane of other organism during symbiotic interaction created_by: janelomax creation_date: 2012-08-01T13:14:42Z [Term] id: GO:0044659 name: cytolysis by virus of host cell namespace: biological_process alt_id: GO:0019077 alt_id: GO:0046756 def: "The killing by a virus of a cell by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, PMID:26728778] synonym: "lytic viral life cycle" RELATED [] synonym: "lytic viral release" EXACT [] synonym: "viral release by cell lysis" EXACT [] synonym: "viral release by host cell lysis" EXACT [] xref: VZ:1077 "Cell lysis" is_a: GO:0039633 ! killing by virus of host cell is_a: GO:0044661 ! disruption by virus of host cell relationship: part_of GO:0019076 ! viral release from host cell created_by: janelomax creation_date: 2012-08-01T13:16:39Z [Term] id: GO:0044660 name: cytolysis by virus via pore formation in host cell membrane namespace: biological_process def: "The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane." [GOC:jl] is_a: GO:0044659 ! cytolysis by virus of host cell relationship: has_part GO:0044658 ! pore formation in membrane of host by symbiont created_by: janelomax creation_date: 2012-08-01T13:23:41Z [Term] id: GO:0044661 name: disruption by virus of host cell namespace: biological_process def: "A process by which a virus has a negative effect on the functioning of the host's cell." [GOC:jl] is_a: GO:0016032 ! viral process is_a: GO:0044004 ! disruption by symbiont of host cell created_by: janelomax creation_date: 2012-08-01T13:41:00Z [Term] id: GO:0044662 name: disruption by virus of host cell membrane namespace: biological_process def: "A process by which a virus has a negative effect on the functioning of a host cellular membrane." [GOC:jl] synonym: "disruption by organism of host cell membrane" EXACT [] synonym: "disruption by virus of host cell membrane" NARROW [GOC:bf, GOC:jl] is_a: GO:0044661 ! disruption by virus of host cell is_a: GO:0051673 ! membrane disruption in other organism is_a: GO:0052025 ! modification by symbiont of host cell membrane created_by: janelomax creation_date: 2012-08-01T13:44:52Z [Term] id: GO:0044663 name: establishment or maintenance of cell type involved in phenotypic switching namespace: biological_process def: "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl] is_a: GO:0009987 ! cellular process relationship: part_of GO:0036166 ! phenotypic switching created_by: janelomax creation_date: 2012-08-07T14:30:07Z [Term] id: GO:0044664 name: obsolete reversion of cell type to default state involved in phenotypic switching namespace: biological_process def: "OBSOLETE. The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl] comment: This term was made obsolete because it is ambiguous. is_obsolete: true created_by: janelomax creation_date: 2012-08-07T14:35:48Z [Term] id: GO:0044665 name: MLL1/2 complex namespace: cellular_component def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999] synonym: "Trx-containing complex" EXACT [] is_a: GO:0035097 ! histone methyltransferase complex created_by: janelomax creation_date: 2012-08-07T14:44:12Z [Term] id: GO:0044666 name: MLL3/4 complex namespace: cellular_component def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] synonym: "Trr/COMPASS-like complex" EXACT [] is_a: GO:0035097 ! histone methyltransferase complex created_by: janelomax creation_date: 2012-08-07T14:46:40Z [Term] id: GO:0044667 name: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)." [GOC:crds] synonym: "(R)-carnitine:gamma-butyrobetaine antiporter activity" EXACT [] synonym: "L-carnitine:4-(trimethylammonio)butanoate antiporter activity" EXACT [] synonym: "L-carnitine:gamma-butyrobetaine antiporter activity" EXACT [] xref: RHEA:29427 is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:1901235 ! (R)-carnitine transmembrane transporter activity is_a: GO:1901236 ! 4-(trimethylammonio)butanoate transmembrane transporter activity created_by: janelomax creation_date: 2012-08-08T11:17:12Z [Term] id: GO:0044668 name: sodium:malonate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)." [GOC:crds] xref: RHEA:33135 is_a: GO:0017153 ! sodium:dicarboxylate symporter activity is_a: GO:1901239 ! malonate(1-) transmembrane transporter activity created_by: janelomax creation_date: 2012-08-08T11:59:48Z [Term] id: GO:0044669 name: sodium:galactoside symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)." [GOC:crds] is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity created_by: janelomax creation_date: 2012-08-08T12:55:32Z [Term] id: GO:0044671 name: sorocarp spore cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass)." [GOC:jl, GOC:rjd] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048837 ! sorocarp sorus development created_by: janelomax creation_date: 2012-08-08T13:10:48Z [Term] id: GO:0044672 name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex namespace: cellular_component def: "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis." [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306] synonym: "carbon monoxide dehydrogenase" BROAD [] synonym: "carbon-monoxide:(acceptor) oxidoreductase complex" BROAD [] synonym: "CO dehydrogenase complex" BROAD [] synonym: "CO dehydrogenase/acetyl-CoA synthase complex" EXACT [] synonym: "CODH" BROAD [] synonym: "CODH/ACS complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2012-08-08T16:06:03Z [Term] id: GO:0044673 name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex namespace: cellular_component def: "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420." [GOC:mengo_curators, PMID:14593448] synonym: "FO-synthase complex" EXACT [] is_a: GO:1990234 ! transferase complex created_by: janelomax creation_date: 2012-08-09T10:49:05Z [Term] id: GO:0044674 name: methyl coenzyme M reductase complex namespace: cellular_component def: "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis." [GOC:mengo_curators, PMID:9367957] is_a: GO:1990234 ! transferase complex created_by: janelomax creation_date: 2012-08-09T10:52:33Z [Term] id: GO:0044675 name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex namespace: cellular_component def: "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:8125106, PMID:8575452] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2012-08-09T10:54:49Z [Term] id: GO:0044676 name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex namespace: cellular_component def: "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:1915887, PMID:8954165] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2012-08-09T10:56:51Z [Term] id: GO:0044677 name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex namespace: cellular_component def: "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis." [GOC:mengo_curators, PMID:8477726] synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex" EXACT [] synonym: "coenzyme M methyltransferase complex" BROAD [] synonym: "methyl-H4MPT" BROAD [] synonym: "N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2012-08-09T10:58:24Z [Term] id: GO:0044678 name: CoB-CoM heterodisulfide reductase complex namespace: cellular_component def: "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine." [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468] synonym: "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex" EXACT [] synonym: "hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex" EXACT [] is_a: GO:1990204 ! oxidoreductase complex created_by: janelomax creation_date: 2012-08-09T11:01:43Z [Term] id: GO:0044679 name: methanophenazine reducing hydrogenase complex namespace: cellular_component def: "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides" [GOC:mengo_curators, PMID:9555882] is_a: GO:1990204 ! oxidoreductase complex created_by: janelomax creation_date: 2012-08-09T11:07:20Z [Term] id: GO:0044680 name: methylthiol:coenzyme M methyltransferase complex namespace: cellular_component def: "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis." [GOC:mengo_curators, PMID:11073950, PMID:9371433] synonym: "methylthiol coenzyme M methyl transferase complex" EXACT [] synonym: "methylthiol:coenzyme M methyl transferase complex" EXACT [] synonym: "methylthiol:CoM methyltransferase complex" EXACT [] is_a: GO:0034708 ! methyltransferase complex created_by: janelomax creation_date: 2012-08-09T11:08:22Z [Term] id: GO:0044681 name: sulfopyruvate decarboxylase complex namespace: cellular_component def: "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis." [GOC:mengo_curators, PMID:10940029] is_a: GO:1902494 ! catalytic complex created_by: janelomax creation_date: 2012-08-09T11:12:47Z [Term] id: GO:0044682 name: archaeal-specific GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+." [GOC:mengo_curators, PMID:17497938] synonym: "Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity" EXACT [] synonym: "MptA activity" NARROW [] is_a: GO:0003933 ! GTP cyclohydrolase activity created_by: janelomax creation_date: 2012-08-15T11:18:40Z [Term] id: GO:0044683 name: methylthiol:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM." [MetaCyc:RXN-8125, PMID:9371433] comment: This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC 2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation. synonym: "methylthiol:coenzyme M methyl transferase activity" EXACT [] xref: EC:2.1.1.251 xref: MetaCyc:RXN-8125 xref: RHEA:32667 is_a: GO:0008168 ! methyltransferase activity created_by: janelomax creation_date: 2012-08-15T11:41:24Z [Term] id: GO:0044684 name: dihydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691] xref: EC:1.5.99.15 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor relationship: part_of GO:2001118 ! tetrahydromethanopterin biosynthetic process created_by: janelomax creation_date: 2012-08-15T13:57:55Z [Term] id: GO:0044685 name: tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O." [GOC:mengo_curators, PMID:12902326] xref: EC:2.1.2 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity created_by: janelomax creation_date: 2012-08-15T14:13:07Z [Term] id: GO:0044686 name: cysteate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-." [GOC:mengo_curators, PMID:19761441] xref: EC:2.5.1.76 xref: MetaCyc:RXN-11108 xref: RHEA:26486 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: janelomax creation_date: 2012-08-15T14:16:05Z [Term] id: GO:0044687 name: geranylfarnesyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate." [GOC:mengo_curators, PMID:20097171] xref: EC:2.5.1.81 xref: MetaCyc:RXN-8813 xref: RHEA:25694 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: janelomax creation_date: 2012-08-15T14:20:25Z [Term] id: GO:0044688 name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+." [GOC:mengo_curators, PMID:19746965] is_a: GO:0008081 ! phosphoric diester hydrolase activity relationship: part_of GO:2001116 ! methanopterin-containing compound biosynthetic process created_by: janelomax creation_date: 2012-08-15T14:28:30Z [Term] id: GO:0044689 name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+." [GOC:mengo_curators, PMID:11948155, PMID:14593448] synonym: "FO synthase" EXACT [] xref: EC:2.5.1.147 xref: MetaCyc:RXN-8079 xref: RHEA:27373 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: janelomax creation_date: 2012-08-15T14:33:17Z [Term] id: GO:0044691 name: tooth eruption namespace: biological_process def: "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption] xref: Wikipedia:Tooth_eruption is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0042476 ! odontogenesis created_by: janelomax creation_date: 2012-08-15T14:58:17Z [Term] id: GO:0044692 name: exoribonuclease activator activity namespace: molecular_function def: "Binds to and increases the activity of an exoribonuclease." [GOC:rb, PMID:22570495] is_a: GO:0008047 ! enzyme activator activity relationship: part_of GO:0032075 ! positive regulation of nuclease activity created_by: janelomax creation_date: 2012-08-15T15:13:57Z [Term] id: GO:0044693 name: trehalose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)." [PMID:11136464] synonym: "trehalose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015574 ! trehalose transmembrane transporter activity created_by: janelomax creation_date: 2012-08-15T15:19:27Z [Term] id: GO:0044694 name: pore-mediated entry of viral genome into host cell namespace: biological_process def: "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, UniProtKB-KW:KW-1172, VZ:979] comment: This mechanism is used by animal viruses such as poliovirus. Various tailed bacteriophages also carry specialized proteins which open a pore or a channel in the host membrane(s) to allow genome delivery into host cytoplasm. synonym: "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172] synonym: "pore-mediated penetration of viral genome into host cell" EXACT [] synonym: "viral entry via genome injection" EXACT [] synonym: "viral genome delivery via icosahedral vertex" NARROW [] synonym: "viral genome translocation" EXACT [] synonym: "viral pore-forming protein" RELATED [GOC:bf] xref: VZ:979 "Pore-mediated penetration of viral genome into host cell" is_a: GO:0046718 ! viral entry into host cell is_a: GO:0046794 ! transport of virus relationship: has_part GO:0039707 ! pore formation by virus in membrane of host cell created_by: janelomax creation_date: 2012-08-16T11:08:02Z [Term] id: GO:0044695 name: Dsc E3 ubiquitin ligase complex namespace: cellular_component def: "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism." [GOC:mah, GOC:vw, PMID:21504829] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031090 ! organelle membrane created_by: janelomax creation_date: 2012-08-16T13:41:48Z [Term] id: GO:0044696 name: killing by virus of host cell by post-segregational killing namespace: biological_process def: "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes." [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system] comment: Note that this process occurs after the cell division partitioning event. synonym: "killing by virus of host cell by PSK" EXACT [] synonym: "killing by virus of host cell by toxin-antitoxin system" EXACT [] is_a: GO:0039633 ! killing by virus of host cell created_by: janelomax creation_date: 2012-08-16T13:58:18Z [Term] id: GO:0044697 name: HICS complex namespace: cellular_component def: "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins." [PMID:22623719] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2012-09-19T13:30:22Z [Term] id: GO:0044698 name: morphogenesis of symbiont in host cell namespace: biological_process def: "The process in which a symbiont undergoes a change in shape or form, within the host's cell." [GOC:jl] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044111 ! development involved in symbiotic interaction relationship: part_of GO:0044118 ! development of symbiont in host cell created_by: janelomax creation_date: 2012-09-19T14:10:53Z [Term] id: GO:0044701 name: obsolete response to stimulus by single organism namespace: biological_process def: "OBSOLETE. A response to a stimulus that involves only one organism." [GOC:jl] comment: This term was made obsolete because we decided that all responses are single-organism. synonym: "response to stimulus by single organism" EXACT [] is_obsolete: true created_by: janelomax creation_date: 2012-09-19T15:40:57Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044705 name: multi-organism reproductive behavior namespace: biological_process def: "The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species." [GOC:jl, GOC:pr] is_a: GO:0019098 ! reproductive behavior is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0051705 ! multi-organism behavior created_by: janelomax creation_date: 2012-09-19T16:02:12Z [Term] id: GO:0044706 name: multi-multicellular organism process namespace: biological_process def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-09-19T16:06:16Z [Term] id: GO:0044713 name: 2-hydroxy-adenosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-adenosine-triphosphate + H2O = 2-hydroxy-adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615] synonym: "2-hydroxy-ATP pyrophosphatase activity" EXACT [] xref: Reactome:R-HSA-2395872 "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP" is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: janelomax creation_date: 2012-10-18T13:22:38Z [Term] id: GO:0044714 name: 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-(deoxy)adenosine-triphosphate + H2O = 2-hydroxy-(deoxy)adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615] synonym: "2-hydroxy-(d)ATP pyrophosphatase activity" EXACT [] xref: Reactome:R-HSA-2395818 "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP" is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity created_by: janelomax creation_date: 2012-10-18T13:24:32Z [Term] id: GO:0044715 name: 8-oxo-dGDP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419] xref: Reactome:R-HSA-2395873 "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP" xref: Reactome:R-HSA-2395879 "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP" is_a: GO:0017110 ! nucleoside-diphosphatase activity created_by: janelomax creation_date: 2012-10-18T13:31:09Z [Term] id: GO:0044716 name: 8-oxo-GDP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419] is_a: GO:0017110 ! nucleoside-diphosphatase activity created_by: janelomax creation_date: 2012-10-18T13:32:39Z [Term] id: GO:0044717 name: 8-hydroxy-dADP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate." [GOC:pde, PMID:22556419] xref: Reactome:R-HSA-2395965 "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP" is_a: GO:0017110 ! nucleoside-diphosphatase activity created_by: janelomax creation_date: 2012-10-18T13:33:32Z [Term] id: GO:0044718 name: siderophore transmembrane transport namespace: biological_process def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "siderophore membrane transport" EXACT [] is_a: GO:0015891 ! siderophore transport is_a: GO:0034755 ! iron ion transmembrane transport created_by: janelomax creation_date: 2012-10-18T13:43:56Z [Term] id: GO:0044719 name: regulation of imaginal disc-derived wing size namespace: biological_process def: "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] is_a: GO:0090066 ! regulation of anatomical structure size relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis created_by: janelomax creation_date: 2012-10-18T13:49:12Z [Term] id: GO:0044720 name: negative regulation of imaginal disc-derived wing size namespace: biological_process def: "Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605] is_a: GO:0044719 ! regulation of imaginal disc-derived wing size created_by: janelomax creation_date: 2012-10-18T13:50:49Z [Term] id: GO:0044721 name: protein import into peroxisome matrix, substrate release namespace: biological_process def: "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane." [PMID:21976670] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0016558 ! protein import into peroxisome matrix created_by: janelomax creation_date: 2012-10-18T14:07:40Z [Term] id: GO:0044722 name: renal phosphate excretion namespace: biological_process def: "The elimination by an organism of phosphate ions in the urine." [GOC:jl, PMID:21451460] synonym: "renal phosphate ion excretion" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion created_by: janelomax creation_date: 2012-10-18T14:54:00Z [Term] id: GO:0044725 name: chromatin reprogramming in the zygote namespace: biological_process def: "The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process." [GOC:sp, PMID:22868271] is_a: GO:0043045 ! DNA methylation involved in embryo development created_by: janelomax creation_date: 2012-10-24T13:53:28Z [Term] id: GO:0044726 name: protection of DNA demethylation of female pronucleus namespace: biological_process def: "The protection of the maternal genome from DNA demethylation in the zygote following fertilization." [GOC:sp, PMID:22868271] is_a: GO:0044030 ! regulation of DNA methylation relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote created_by: janelomax creation_date: 2012-10-24T14:10:36Z [Term] id: GO:0044727 name: DNA demethylation of male pronucleus namespace: biological_process def: "The active DNA demethylation of the paternal genome that takes place before the first cell division." [GOC:sp, PMID:22868271] is_a: GO:0043045 ! DNA methylation involved in embryo development relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote created_by: janelomax creation_date: 2012-10-24T14:25:35Z [Term] id: GO:0044728 name: DNA methylation or demethylation namespace: biological_process def: "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl] synonym: "changes in DNA methylation" RELATED [] is_a: GO:0006304 ! DNA modification created_by: janelomax creation_date: 2012-10-24T14:49:41Z [Term] id: GO:0044729 name: hemi-methylated DNA-binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, GOC:sp, PMID:18772889] synonym: "double-stranded hemi-methylated DNA binding" EXACT [] is_a: GO:0003690 ! double-stranded DNA binding created_by: janelomax creation_date: 2012-10-24T14:58:14Z [Term] id: GO:0044730 name: bone sialoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin." [PMID:10642520] synonym: "bone sialoprotein II binding" EXACT [] xref: InterPro:IPR008412 is_a: GO:0005515 ! protein binding is_a: GO:0050840 ! extracellular matrix binding created_by: janelomax creation_date: 2012-11-06T13:05:56Z [Term] id: GO:0044731 name: Ost-alpha/Ost-beta complex namespace: cellular_component def: "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity." [PMID:17650074, PMID:22535958] synonym: "(Ost)2 complex" RELATED [] synonym: "Ost alpha-Ost beta complex" EXACT [] synonym: "SLC51 complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex created_by: janelomax creation_date: 2012-11-06T13:42:06Z [Term] id: GO:0044732 name: mitotic spindle pole body namespace: cellular_component def: "The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:mah, GOC:vw] is_a: GO:0005816 ! spindle pole body created_by: janelomax creation_date: 2012-11-06T15:44:02Z [Term] id: GO:0044733 name: envenomation resulting in modulation of acid-sensing ion channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] synonym: "envenomation resulting in modulation of ASIC channel activity in other organism" EXACT [] is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in other organism relationship: has_part GO:0044737 ! modulation of acid-sensing ion channel in other organism created_by: janelomax creation_date: 2012-11-06T15:58:36Z [Term] id: GO:0044734 name: envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] synonym: "envenomation resulting in positive regulation of ASIC channel activity in other organism" EXACT [] is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in other organism relationship: has_part GO:0044739 ! positive regulation of acid-sensing ion channel in other organism created_by: janelomax creation_date: 2012-11-06T16:02:01Z [Term] id: GO:0044735 name: envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] synonym: "envenomation resulting in negative regulation of ASIC channel activity in other organism" EXACT [] is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in other organism relationship: has_part GO:0044738 ! negative regulation of acid-sensing ion channel in other organism created_by: janelomax creation_date: 2012-11-06T16:05:58Z [Term] id: GO:0044736 name: acid-sensing ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex." [GOC:jl] synonym: "ASIC activity" EXACT [] xref: Reactome:R-HSA-2671885 "ASICs transport extracellular Na+ to cytosol" xref: Wikipedia:Acid-sensing_ion_channel is_a: GO:0015280 ! ligand-gated sodium channel activity created_by: janelomax creation_date: 2012-11-06T16:36:37Z [Term] id: GO:0044737 name: modulation of acid-sensing ion channel in other organism namespace: biological_process def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism." [GOC:jl] synonym: "regulation of acid-sensing ion channel in other organism" EXACT [] synonym: "regulation of ASIC channel in other organism" EXACT [] is_a: GO:0044561 ! modulation of ion channel activity in other organism created_by: janelomax creation_date: 2012-11-06T16:51:24Z [Term] id: GO:0044738 name: negative regulation of acid-sensing ion channel in other organism namespace: biological_process def: "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl] synonym: "negative regulation of ASIC channel in other organism" EXACT [] is_a: GO:0044737 ! modulation of acid-sensing ion channel in other organism created_by: janelomax creation_date: 2012-11-06T16:55:23Z [Term] id: GO:0044739 name: positive regulation of acid-sensing ion channel in other organism namespace: biological_process def: "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl] synonym: "positive regulation of ASIC channel in other organism" EXACT [] is_a: GO:0044737 ! modulation of acid-sensing ion channel in other organism created_by: janelomax creation_date: 2012-11-06T16:56:27Z [Term] id: GO:0044740 name: negative regulation of sensory perception of pain in other organism namespace: biological_process def: "A process that negatively regulates the sensory perception of pain in a different organism." [GOC:fj, GOC:jl] synonym: "inhibition of sensory perception of pain in another organism" EXACT [] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0044465 ! modulation of sensory perception of pain in other organism created_by: janelomax creation_date: 2012-11-07T13:43:10Z [Term] id: GO:0044741 name: envenomation resulting in negative regulation of sensory perception of pain in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] synonym: "envenomation resulting in inhibition of sensory perception of pain in other organism" EXACT [] is_a: GO:0044742 ! envenomation resulting in modulation of sensory perception of pain in other organism relationship: has_part GO:0044740 ! negative regulation of sensory perception of pain in other organism created_by: janelomax creation_date: 2012-11-07T14:02:14Z [Term] id: GO:0044742 name: envenomation resulting in modulation of sensory perception of pain in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] synonym: "envenomation resulting in regulation of sensory perception of pain in other organism" EXACT [] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:0044465 ! modulation of sensory perception of pain in other organism created_by: janelomax creation_date: 2012-11-07T14:26:38Z [Term] id: GO:0044743 name: protein transmembrane import into intracellular organelle namespace: biological_process def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl] is_a: GO:0017038 ! protein import is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072594 ! establishment of protein localization to organelle created_by: janelomax creation_date: 2012-11-07T15:37:36Z [Term] id: GO:0044747 name: mature miRNA 3'-end processing namespace: biological_process def: "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293] synonym: "miRNA 3' end terminal trimming" BROAD [] synonym: "miRNA 3'-end processing" BROAD [] synonym: "miRNA trimming" BROAD [] is_a: GO:0010586 ! miRNA metabolic process is_a: GO:0043628 ! ncRNA 3'-end processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA created_by: janelomax creation_date: 2012-11-15T13:45:21Z [Term] id: GO:0044748 name: 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart] synonym: "exonucleolytic trimming to generate 3' end of miRNA" BROAD [] is_a: GO:0000175 ! 3'-5'-exoribonuclease activity intersection_of: GO:0000175 ! 3'-5'-exoribonuclease activity intersection_of: part_of GO:0044747 ! mature miRNA 3'-end processing relationship: part_of GO:0044747 ! mature miRNA 3'-end processing created_by: janelomax creation_date: 2012-11-20T13:48:29Z [Term] id: GO:0044750 name: high-affinity nickel cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl] is_a: GO:0015099 ! nickel cation transmembrane transporter activity created_by: janelomax creation_date: 2012-11-20T15:15:59Z [Term] id: GO:0044751 name: cellular response to human chorionic gonadotropin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635] synonym: "cellular response to human chorionic gonadotrophin stimulus" EXACT [GOC:dph] is_a: GO:0044752 ! response to human chorionic gonadotropin is_a: GO:0071371 ! cellular response to gonadotropin stimulus created_by: janelomax creation_date: 2012-11-20T16:19:45Z [Term] id: GO:0044752 name: response to human chorionic gonadotropin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635] synonym: "response to human chorionic gonadotropin stimulus" EXACT [GOC:dos] is_a: GO:0034698 ! response to gonadotropin created_by: janelomax creation_date: 2012-11-20T16:21:08Z [Term] id: GO:0044753 name: amphisome namespace: cellular_component def: "Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327] is_a: GO:0005776 ! autophagosome created_by: janelomax creation_date: 2012-11-27T15:35:25Z [Term] id: GO:0044754 name: autolysosome namespace: cellular_component def: "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921] synonym: "autophagolysosome" EXACT [] synonym: "AVd" EXACT [] synonym: "degrading autophagic vacuole" EXACT [] xref: NIF_Subcellular:sao8444068431 is_a: GO:0005767 ! secondary lysosome is_a: GO:0005776 ! autophagosome created_by: janelomax creation_date: 2012-11-27T15:42:12Z [Term] id: GO:0044758 name: modulation by symbiont of host synaptic transmission namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl] synonym: "regulation by symbiont of host synaptic transmission" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0007268 ! chemical synaptic transmission created_by: janelomax creation_date: 2012-12-06T15:34:05Z [Term] id: GO:0044759 name: negative regulation by symbiont of host synaptic transmission namespace: biological_process def: "Any process in which a symbiont organism decreases the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl] is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission is_a: GO:0050805 ! negative regulation of synaptic transmission created_by: janelomax creation_date: 2012-12-06T15:37:25Z [Term] id: GO:0044760 name: modulation by symbiont of host cholinergic synaptic transmission namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl] synonym: "regulation by symbiont of host cholinergic synaptic transmission" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission created_by: janelomax creation_date: 2012-12-06T15:39:46Z [Term] id: GO:0044761 name: negative regulation by symbiont of host cholinergic synaptic transmission namespace: biological_process def: "Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl] is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0044759 ! negative regulation by symbiont of host synaptic transmission is_a: GO:0044760 ! modulation by symbiont of host cholinergic synaptic transmission created_by: janelomax creation_date: 2012-12-06T15:43:53Z [Term] id: GO:0044762 name: negative regulation by symbiont of host neurotransmitter secretion namespace: biological_process def: "Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism." [GOC:jl] is_a: GO:0044079 ! modulation by symbiont of host neurotransmitter secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: negatively_regulates GO:0007269 ! neurotransmitter secretion created_by: janelomax creation_date: 2012-12-06T15:52:20Z [Term] id: GO:0044764 name: multi-organism cellular process namespace: biological_process def: "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl] is_a: GO:0009987 ! cellular process is_a: GO:0051704 ! multi-organism process created_by: janelomax creation_date: 2012-12-11T17:00:50Z [Term] id: GO:0044766 name: multi-organism transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl] is_a: GO:0006810 ! transport is_a: GO:1902579 ! multi-organism localization created_by: janelomax creation_date: 2012-12-13T16:25:50Z [Term] id: GO:0044768 name: NMS complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an NMS complex. The NMS complex results from the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) and is required for kinetochore assembly." [GOC:vw, PMID:22561345] synonym: "KMN complex interaction involved in chromosome segregation" EXACT [] synonym: "KMN kinetochore network assembly" EXACT [] synonym: "KMN kinetochore network formation" EXACT [] synonym: "KMN network assembly involved in chromosome segregation" EXACT [] synonym: "KNL-1-Mis12-Ndc80 assembly" EXACT [] synonym: "KNL-1-Mis12-Ndc80 formation" EXACT [] synonym: "Ndc80-MIND-Spc7 complex assembly" EXACT [] synonym: "Ndc80-MIND-Spc7 complex formation" EXACT [] synonym: "NMS complex assembly involved in kinetochore assembly" EXACT [] synonym: "NMS complex association involved in chromosome segregation" EXACT [] synonym: "NMS complex formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0051382 ! kinetochore assembly created_by: janelomax creation_date: 2012-12-19T14:44:56Z [Term] id: GO:0044769 name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism namespace: molecular_function def: "Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl] is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity created_by: janelomax creation_date: 2013-02-20T13:41:38Z [Term] id: GO:0044770 name: cell cycle phase transition namespace: biological_process def: "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] synonym: "cell cycle transition" EXACT [] is_a: GO:0022402 ! cell cycle process created_by: janelomax creation_date: 2013-02-28T12:54:59Z [Term] id: GO:0044771 name: meiotic cell cycle phase transition namespace: biological_process def: "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle] synonym: "cell cycle transition" BROAD [] is_a: GO:0044770 ! cell cycle phase transition is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0044770 ! cell cycle phase transition intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: janelomax creation_date: 2013-02-28T13:08:17Z [Term] id: GO:0044772 name: mitotic cell cycle phase transition namespace: biological_process def: "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0044770 ! cell cycle phase transition intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: janelomax creation_date: 2013-02-28T13:09:33Z [Term] id: GO:0044773 name: mitotic DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] is_a: GO:0000077 ! DNA damage checkpoint is_a: GO:0044774 ! mitotic DNA integrity checkpoint intersection_of: GO:0000077 ! DNA damage checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: janelomax creation_date: 2013-02-28T15:55:25Z [Term] id: GO:0044774 name: mitotic DNA integrity checkpoint namespace: biological_process alt_id: GO:0070683 def: "A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [] synonym: "topo II checkpoint" EXACT [GOC:jp] synonym: "topoisomerase II checkpoint" EXACT [GOC:jp] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031570 ! DNA integrity checkpoint intersection_of: GO:0031570 ! DNA integrity checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: janelomax creation_date: 2013-02-28T16:07:26Z [Term] id: GO:0044775 name: DNA polymerase III, beta sliding clamp processivity factor complex namespace: cellular_component def: "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species." [GOC:jl, UniProt:O73947] is_a: GO:0044796 ! DNA polymerase processivity factor complex relationship: part_of GO:0009360 ! DNA polymerase III complex created_by: janelomax creation_date: 2013-03-13T13:59:48Z [Term] id: GO:0044776 name: DNA polymerase III, core complex namespace: cellular_component def: "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities." [GOC:jl, UniProt:P06710] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0009360 ! DNA polymerase III complex created_by: janelomax creation_date: 2013-03-13T14:09:38Z [Term] id: GO:0044777 name: single-stranded DNA-binding protein complex namespace: cellular_component def: "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair." [GOC:jl, UniProt:P0AGE0] synonym: "SSB complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0009295 ! nucleoid created_by: janelomax creation_date: 2013-03-14T13:14:00Z [Term] id: GO:0044778 name: meiotic DNA integrity checkpoint namespace: biological_process def: "A meiotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] is_a: GO:0031570 ! DNA integrity checkpoint is_a: GO:0033313 ! meiotic cell cycle checkpoint intersection_of: GO:0031570 ! DNA integrity checkpoint intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: janelomax creation_date: 2013-03-20T16:46:06Z [Term] id: GO:0044779 name: meiotic spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle." [GOC:mtg_cell_cycle] is_a: GO:0031577 ! spindle checkpoint is_a: GO:0033313 ! meiotic cell cycle checkpoint is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle intersection_of: GO:0031577 ! spindle checkpoint intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: janelomax creation_date: 2013-03-21T14:01:28Z [Term] id: GO:0044780 name: bacterial-type flagellum assembly namespace: biological_process def: "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl] synonym: "bacterial flagellum assembly" EXACT [] is_a: GO:0030031 ! cell projection assembly is_a: GO:0044781 ! bacterial-type flagellum organization is_a: GO:0070925 ! organelle assembly created_by: janelomax creation_date: 2013-03-27T15:00:43Z [Term] id: GO:0044781 name: bacterial-type flagellum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl] is_a: GO:0006996 ! organelle organization is_a: GO:0030030 ! cell projection organization created_by: janelomax creation_date: 2013-03-27T15:07:00Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: janelomax creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0044783 name: G1 DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "G1/S DNA damage checkpoint" EXACT [] is_a: GO:0000077 ! DNA damage checkpoint created_by: janelomax creation_date: 2013-05-02T12:52:39Z [Term] id: GO:0044784 name: metaphase/anaphase transition of cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0044770 ! cell cycle phase transition created_by: janelomax creation_date: 2013-05-02T13:09:34Z [Term] id: GO:0044785 name: metaphase/anaphase transition of meiotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis." [GOC:mtg_cell_cycle] synonym: "meiotic metaphase/anaphase transition" EXACT [] is_a: GO:0044771 ! meiotic cell cycle phase transition is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: janelomax creation_date: 2013-05-02T13:11:28Z [Term] id: GO:0044786 name: cell cycle DNA replication namespace: biological_process def: "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006261 ! DNA-dependent DNA replication intersection_of: part_of GO:0007049 ! cell cycle created_by: janelomax creation_date: 2013-05-02T15:52:22Z [Term] id: GO:0044787 name: bacterial-type DNA replication namespace: biological_process def: "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome." [GOC:mtg_cell_cycle] synonym: "bacterial-type cell cycle DNA replication" EXACT [] is_a: GO:0044786 ! cell cycle DNA replication created_by: janelomax creation_date: 2013-05-02T15:54:16Z [Term] id: GO:0044788 name: modulation by host of viral process namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected." [GOC:jl] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology created_by: janelomax creation_date: 2013-06-06T10:50:49Z [Term] id: GO:0044789 name: modulation by host of viral release from host cell namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167] is_a: GO:0044788 ! modulation by host of viral process is_a: GO:1902186 ! regulation of viral release from host cell intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: regulates GO:0019076 ! viral release from host cell created_by: janelomax creation_date: 2013-06-06T10:51:10Z [Term] id: GO:0044790 name: negative regulation by host of viral release from host cell namespace: biological_process def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167] is_a: GO:0044789 ! modulation by host of viral release from host cell is_a: GO:0044793 ! negative regulation by host of viral process is_a: GO:1902187 ! negative regulation of viral release from host cell intersection_of: GO:0044793 ! negative regulation by host of viral process intersection_of: negatively_regulates GO:0019076 ! viral release from host cell created_by: janelomax creation_date: 2013-06-06T10:51:27Z [Term] id: GO:0044791 name: positive regulation by host of viral release from host cell namespace: biological_process def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl] is_a: GO:0044789 ! modulation by host of viral release from host cell is_a: GO:0044794 ! positive regulation by host of viral process is_a: GO:1902188 ! positive regulation of viral release from host cell intersection_of: GO:0044794 ! positive regulation by host of viral process intersection_of: positively_regulates GO:0019076 ! viral release from host cell created_by: janelomax creation_date: 2013-06-06T10:51:48Z [Term] id: GO:0044793 name: negative regulation by host of viral process namespace: biological_process def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected." [GOC:jl] is_a: GO:0044788 ! modulation by host of viral process is_a: GO:0048525 ! negative regulation of viral process intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: negatively_regulates GO:0016032 ! viral process created_by: janelomax creation_date: 2013-06-06T11:16:00Z [Term] id: GO:0044794 name: positive regulation by host of viral process namespace: biological_process def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl] is_a: GO:0044788 ! modulation by host of viral process is_a: GO:0048524 ! positive regulation of viral process intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: positively_regulates GO:0016032 ! viral process created_by: janelomax creation_date: 2013-06-06T11:33:51Z [Term] id: GO:0044795 name: trans-Golgi network to recycling endosome transport namespace: biological_process def: "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes." [GOC:lb, PMID:18779367] is_a: GO:0016197 ! endosomal transport created_by: janelomax creation_date: 2013-08-27T16:04:00Z [Term] id: GO:0044796 name: DNA polymerase processivity factor complex namespace: cellular_component def: "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: janelomax creation_date: 2013-08-28T11:16:14Z [Term] id: GO:0044797 name: cytoplasmic transcription factor complex namespace: cellular_component def: "A protein complex, located in the cytoplasm, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] is_a: GO:0005667 ! transcription factor complex intersection_of: GO:0005667 ! transcription factor complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm created_by: janelomax creation_date: 2013-08-28T12:11:37Z [Term] id: GO:0044798 name: nuclear transcription factor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] is_a: GO:0005667 ! transcription factor complex intersection_of: GO:0005667 ! transcription factor complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus created_by: janelomax creation_date: 2013-08-28T12:12:27Z [Term] id: GO:0044799 name: NarGHI complex namespace: cellular_component def: "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit." [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535] synonym: "cytoplasmic membrane-bound quinol-nitrate oxidoreductase" EXACT [] synonym: "nitrate reductase A" EXACT [] is_a: GO:0009325 ! nitrate reductase complex is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0070470 ! plasma membrane respirasome created_by: janelomax creation_date: 2013-08-29T14:17:41Z [Term] id: GO:0044800 name: multi-organism membrane fusion namespace: biological_process def: "The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism." [GOC:jl] is_a: GO:0044803 ! multi-organism membrane organization is_a: GO:0061025 ! membrane fusion created_by: janelomax creation_date: 2013-09-10T15:06:11Z [Term] id: GO:0044803 name: multi-organism membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism." [GOC:jl] is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0061024 ! membrane organization created_by: janelomax creation_date: 2013-09-10T15:11:41Z [Term] id: GO:0044804 name: autophagy of nucleus namespace: biological_process def: "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549] synonym: "nucleophagy" RELATED [] synonym: "nucleus degradation" EXACT [] is_a: GO:0006914 ! autophagy created_by: janelomax creation_date: 2013-09-10T15:50:25Z [Term] id: GO:0044805 name: late nucleophagy namespace: biological_process def: "A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199] synonym: "LN" EXACT [] is_a: GO:0044804 ! autophagy of nucleus created_by: janelomax creation_date: 2013-09-10T15:58:23Z [Term] id: GO:0044806 name: G-quadruplex DNA unwinding namespace: biological_process def: "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261] is_a: GO:0032392 ! DNA geometric change created_by: janelomax creation_date: 2013-09-10T16:16:16Z [Term] id: GO:0044807 name: macrophage migration inhibitory factor production namespace: biological_process def: "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "MIF production" EXACT [] is_a: GO:0001816 ! cytokine production created_by: janelomax creation_date: 2013-09-11T12:04:09Z [Term] id: GO:0044808 name: Oncostatin M production namespace: biological_process def: "The appearance of Oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "OSM production" EXACT [] is_a: GO:0001816 ! cytokine production created_by: janelomax creation_date: 2013-09-11T12:18:00Z [Term] id: GO:0044809 name: chemokine (C-C motif) ligand 17 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CCL17 production" EXACT [] synonym: "TARC production" EXACT [] synonym: "thymus and activation regulated chemokine production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: janelomax creation_date: 2013-09-11T12:21:31Z [Term] id: GO:0044812 name: fermentative hydrogen production namespace: biological_process def: "The fermentation of organic substances with a net release of hydrogen." [GOC:mengo_curators] synonym: "carbohydrate fermentation" EXACT [] xref: Wikipedia:Fermentative_hydrogen_production is_a: GO:0006113 ! fermentation is_a: GO:1902422 ! hydrogen biosynthetic process created_by: janelomax creation_date: 2013-09-18T14:09:47Z [Term] id: GO:0044813 name: glycolytic fermentation via PFOR pathway namespace: biological_process def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species." [GOC:mengo_curators, PMID:20395274, PMID:20692761] is_a: GO:0019660 ! glycolytic fermentation intersection_of: GO:0019660 ! glycolytic fermentation intersection_of: has_part GO:0019164 ! pyruvate synthase activity relationship: has_part GO:0019164 ! pyruvate synthase activity created_by: janelomax creation_date: 2013-09-18T16:04:00Z [Term] id: GO:0044814 name: glycolytic fermentation via PFL pathway namespace: biological_process def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli." [GOC:mengo_curators, PMID:20395274, PMID:20692761] is_a: GO:0019660 ! glycolytic fermentation intersection_of: GO:0019660 ! glycolytic fermentation intersection_of: has_part GO:0008861 ! formate C-acetyltransferase activity relationship: has_part GO:0008861 ! formate C-acetyltransferase activity created_by: janelomax creation_date: 2013-09-18T16:56:02Z [Term] id: GO:0044815 name: DNA packaging complex namespace: cellular_component def: "A protein complex that plays a role in the process of DNA packaging." [GOC:jl] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2013-09-19T11:33:45Z [Term] id: GO:0044816 name: Nsk1-Dlc1 complex namespace: cellular_component def: "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation." [GOC:vw, PMID:22065639] is_a: GO:0032991 ! protein-containing complex created_by: janelomax creation_date: 2013-10-21T14:38:16Z [Term] id: GO:0044817 name: hydrogen generation via biophotolysis namespace: biological_process def: "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae." [GOC:mengo_curators, PMID:20395274, PMID:20692761] synonym: "hydrogen biosynthesis via biophotolysis" EXACT [] is_a: GO:1902422 ! hydrogen biosynthetic process created_by: janelomax creation_date: 2013-10-22T14:36:54Z [Term] id: GO:0044818 name: mitotic G2/M transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle created_by: janelomax creation_date: 2013-11-19T14:20:00Z [Term] id: GO:0044819 name: mitotic G1/S transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle created_by: janelomax creation_date: 2013-11-19T14:31:14Z [Term] id: GO:0044820 name: mitotic telomere tethering at nuclear periphery namespace: biological_process def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:25778919] is_a: GO:0034398 ! telomere tethering at nuclear periphery relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery created_by: janelomax creation_date: 2013-11-19T16:16:22Z [Term] id: GO:0044821 name: meiotic telomere tethering at nuclear periphery namespace: biological_process def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0034398 ! telomere tethering at nuclear periphery is_a: GO:0045141 ! meiotic telomere clustering created_by: janelomax creation_date: 2013-11-19T16:18:09Z [Term] id: GO:0044823 name: retroviral integrase activity namespace: molecular_function def: "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism." [PMID:19091057] is_a: GO:0008907 ! integrase activity relationship: part_of GO:0044826 ! viral genome integration into host DNA created_by: janelomax creation_date: 2014-02-04T14:09:34Z [Term] id: GO:0044824 name: retroviral 3' processing activity namespace: molecular_function def: "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823, Reactome:R-HSA-164522] comment: This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification. synonym: "3' processing reaction" EXACT [] synonym: "3'-processing activity" EXACT [] is_a: GO:0004520 ! endodeoxyribonuclease activity relationship: part_of GO:0044823 ! retroviral integrase activity created_by: janelomax creation_date: 2014-02-04T14:51:24Z [Term] id: GO:0044825 name: retroviral strand transfer activity namespace: molecular_function def: "Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction." [PMID:22580823] synonym: "strand transfer reaction" EXACT [] is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: part_of GO:0044823 ! retroviral integrase activity created_by: janelomax creation_date: 2014-02-04T15:16:39Z [Term] id: GO:0044826 name: viral genome integration into host DNA namespace: biological_process def: "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses." [PMID:19091057] synonym: "viral genome integration" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle created_by: janelomax creation_date: 2014-02-04T16:58:43Z [Term] id: GO:0044827 name: modulation by host of viral genome replication namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl] synonym: "regulation by host of viral genome reproduction" EXACT [] is_a: GO:0044788 ! modulation by host of viral process is_a: GO:0045069 ! regulation of viral genome replication intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: regulates GO:0019079 ! viral genome replication created_by: janelomax creation_date: 2014-02-06T11:26:45Z [Term] id: GO:0044828 name: negative regulation by host of viral genome replication namespace: biological_process def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:jl] is_a: GO:0044793 ! negative regulation by host of viral process is_a: GO:0044827 ! modulation by host of viral genome replication is_a: GO:0045071 ! negative regulation of viral genome replication intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: negatively_regulates GO:0019079 ! viral genome replication created_by: janelomax creation_date: 2014-02-06T11:34:23Z [Term] id: GO:0044829 name: positive regulation by host of viral genome replication namespace: biological_process def: "A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication." [GOC:jl] is_a: GO:0044794 ! positive regulation by host of viral process is_a: GO:0044827 ! modulation by host of viral genome replication is_a: GO:0045070 ! positive regulation of viral genome replication intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: positively_regulates GO:0019079 ! viral genome replication created_by: janelomax creation_date: 2014-02-06T11:35:07Z [Term] id: GO:0044830 name: modulation by host of viral RNA genome replication namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication." [GOC:jl] synonym: "regulation by host of viral RNA genome replication" EXACT [] is_a: GO:0044827 ! modulation by host of viral genome replication intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: regulates GO:0039694 ! viral RNA genome replication relationship: regulates GO:0039694 ! viral RNA genome replication created_by: janelomax creation_date: 2014-02-06T11:43:16Z [Term] id: GO:0044831 name: modulation by virus of host cytokine production namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism." [GOC:jl] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0075528 ! modulation by virus of host immune response intersection_of: GO:0075528 ! modulation by virus of host immune response intersection_of: regulates GO:0001816 ! cytokine production created_by: janelomax creation_date: 2014-02-06T12:49:02Z [Term] id: GO:0044832 name: positive regulation by virus of host cytokine production namespace: biological_process def: "The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism." [GOC:jl] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0044831 ! modulation by virus of host cytokine production intersection_of: GO:0075528 ! modulation by virus of host immune response intersection_of: positively_regulates GO:0001816 ! cytokine production created_by: janelomax creation_date: 2014-02-06T13:04:23Z [Term] id: GO:0044833 name: modulation by virus of host protein transport namespace: biological_process def: "Any viral process that modulates the frequency, rate or extent of protein transport in its host organism." [GOC:jl, PMID:22334672] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0051223 ! regulation of protein transport is_a: GO:0052038 ! modulation by symbiont of host intracellular transport intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: regulates GO:0015031 ! protein transport created_by: janelomax creation_date: 2014-02-06T13:25:52Z [Term] id: GO:0044834 name: retroviral intasome namespace: cellular_component def: "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome." [PMID:20118915] is_a: GO:0032993 ! protein-DNA complex created_by: janelomax creation_date: 2014-02-06T14:33:39Z [Term] id: GO:0044835 name: hydrogen generation via nitrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria." [GOC:mengo_curators, PMID:22128188] is_a: GO:1902422 ! hydrogen biosynthetic process intersection_of: GO:1902422 ! hydrogen biosynthetic process intersection_of: has_part GO:0016163 ! nitrogenase activity relationship: has_part GO:0016163 ! nitrogenase activity created_by: janelomax creation_date: 2014-02-19T14:59:15Z [Term] id: GO:0044836 name: D-xylose fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP." [GOC:mengo_curators] is_a: GO:0006113 ! fermentation is_a: GO:0044577 ! xylose catabolic process to ethanol created_by: janelomax creation_date: 2014-02-19T16:14:57Z [Term] id: GO:0044837 name: actomyosin contractile ring organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle] synonym: "cytokinesis, actomyosin contractile ring organization" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis created_by: janelomax creation_date: 2014-02-26T15:31:31Z [Term] id: GO:0044838 name: cell quiescence namespace: biological_process def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah] comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "cell cycle quiescence" RELATED [GOC:mah] synonym: "cellular quiescence" EXACT [GOC:mah] synonym: "G0 phase" RELATED [GOC:mah] synonym: "quiescence" BROAD [GOC:mah] is_a: GO:0022403 ! cell cycle phase created_by: janelomax creation_date: 2014-02-26T16:15:51Z [Term] id: GO:0044839 name: cell cycle G2/M phase transition namespace: biological_process def: "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition created_by: janelomax creation_date: 2014-03-05T14:56:45Z [Term] id: GO:0044840 name: gut granule namespace: cellular_component def: "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage." [GOC:kmv, PMID:22916203, PMID:24204312] is_a: GO:0031410 ! cytoplasmic vesicle created_by: janelomax creation_date: 2014-03-25T11:56:41Z [Term] id: GO:0044841 name: gut granule membrane namespace: cellular_component def: "The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312] is_a: GO:0031090 ! organelle membrane intersection_of: GO:0031090 ! organelle membrane intersection_of: part_of GO:0044840 ! gut granule relationship: part_of GO:0044840 ! gut granule created_by: janelomax creation_date: 2014-03-25T12:02:05Z [Term] id: GO:0044842 name: gut granule lumen namespace: cellular_component def: "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0043233 ! organelle lumen intersection_of: part_of GO:0044840 ! gut granule relationship: part_of GO:0044840 ! gut granule created_by: janelomax creation_date: 2014-03-25T12:02:32Z [Term] id: GO:0044843 name: cell cycle G1/S phase transition namespace: biological_process def: "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition created_by: janelomax creation_date: 2014-03-25T16:33:47Z [Term] id: GO:0044844 name: meiotic interphase II namespace: biological_process def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051328 ! meiotic interphase is_a: GO:0098765 ! meiosis II cell cycle phase created_by: janelomax creation_date: 2014-03-26T16:52:27Z [Term] id: GO:0044845 name: chain elongation of O-linked mannose residue namespace: biological_process def: "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules." [GOC:jl, PMID:19429925] comment: Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family. is_a: GO:0035268 ! protein mannosylation created_by: janelomax creation_date: 2014-05-08T15:56:39Z [Term] id: GO:0044846 name: negative regulation by symbiont of indole acetic acid levels in host namespace: biological_process def: "Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646] synonym: "negative regulation by symbiont of auxin levels in host" EXACT [] synonym: "negative regulation by symbiont of IAA levels in host" EXACT [] is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host created_by: janelomax creation_date: 2014-05-13T11:08:04Z [Term] id: GO:0044847 name: iron acquisition from host namespace: biological_process alt_id: GO:0052099 def: "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell." [PMID:15487950, PMID:22865843] comment: Merged terms as requested: https://github.com/geneontology/go-ontology/issues/17896. synonym: "acquisition by organism of nutrients from host via siderophores" RELATED [] synonym: "acquisition by symbiont of nutrients from host via siderophores" NARROW [] synonym: "heme acquisition" RELATED [] synonym: "iron acquisition" BROAD [] synonym: "iron acquisition by symbiont from host" EXACT [] synonym: "iron acquisition by symbiont from host heme" NARROW [] is_a: GO:0044002 ! acquisition of nutrients from host created_by: janelomax creation_date: 2014-05-13T13:40:59Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_manually_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0046879 ! hormone secretion disjoint_from: GO:0048511 ! rhythmic process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0051704 ! multi-organism process disjoint_from: GO:0071840 ! cellular component organization or biogenesis disjoint_from: GO:0098743 ! cell aggregation created_by: janelomax creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044849 name: estrous cycle namespace: biological_process def: "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur." [GOC:jl, Wikipedia:Estrous_cycle] xref: Wikipedia:Estrous_cycle is_a: GO:0042698 ! ovulation cycle created_by: janelomax creation_date: 2014-07-16T13:41:42Z [Term] id: GO:0044850 name: menstrual cycle namespace: biological_process def: "A type of ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:jl] xref: Wikipedia:Menstrual_cycle is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042698 ! ovulation cycle created_by: janelomax creation_date: 2014-07-16T13:51:29Z [Term] id: GO:0044851 name: hair cycle phase namespace: biological_process def: "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase created_by: janelomax creation_date: 2014-07-16T14:22:09Z [Term] id: GO:0044852 name: nonrepetitive DNA condensation namespace: biological_process def: "The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells." [GOC:jl, PMID:10811823] synonym: "nonrepetitive DNA packaging" EXACT [] is_a: GO:0006323 ! DNA packaging relationship: part_of GO:0030261 ! chromosome condensation created_by: janelomax creation_date: 2014-07-17T14:13:23Z [Term] id: GO:0044853 name: plasma membrane raft namespace: cellular_component def: "A membrane raft that is part of the plasma membrane." [GOC:jl] is_a: GO:0045121 ! membrane raft is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0045121 ! membrane raft intersection_of: part_of GO:0005886 ! plasma membrane created_by: janelomax creation_date: 2014-07-23T15:55:23Z [Term] id: GO:0044854 name: plasma membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft." [GOC:jl] is_a: GO:0001765 ! membrane raft assembly is_a: GO:0044857 ! plasma membrane raft organization created_by: janelomax creation_date: 2014-07-23T15:58:16Z [Term] id: GO:0044855 name: plasma membrane raft distribution namespace: biological_process def: "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane." [GOC:jl] is_a: GO:0031580 ! membrane raft distribution is_a: GO:0044856 ! plasma membrane raft localization created_by: janelomax creation_date: 2014-07-23T16:00:41Z [Term] id: GO:0044856 name: plasma membrane raft localization namespace: biological_process def: "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location." [GOC:jl] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0051665 ! membrane raft localization created_by: janelomax creation_date: 2014-07-23T16:12:22Z [Term] id: GO:0044857 name: plasma membrane raft organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts." [GOC:jl] is_a: GO:0031579 ! membrane raft organization relationship: part_of GO:0007009 ! plasma membrane organization created_by: janelomax creation_date: 2014-07-23T16:20:07Z [Term] id: GO:0044858 name: plasma membrane raft polarization namespace: biological_process def: "The clustering and aggregation of plasma membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [GOC:jl] is_a: GO:0001766 ! membrane raft polarization is_a: GO:0044855 ! plasma membrane raft distribution created_by: janelomax creation_date: 2014-07-23T16:21:39Z [Term] id: GO:0044859 name: protein insertion into plasma membrane raft namespace: biological_process def: "The process in which a protein is incorporated into a plasma membrane raft." [GOC:jl] is_a: GO:0044860 ! protein localization to plasma membrane raft is_a: GO:0071210 ! protein insertion into membrane raft is_a: GO:0098737 ! protein insertion into plasma membrane created_by: janelomax creation_date: 2014-07-23T16:23:20Z [Term] id: GO:0044860 name: protein localization to plasma membrane raft namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft." [GOC:jl] is_a: GO:1903044 ! protein localization to membrane raft is_a: GO:1990778 ! protein localization to cell periphery created_by: janelomax creation_date: 2014-07-23T16:25:01Z [Term] id: GO:0044861 name: protein transport into plasma membrane raft namespace: biological_process def: "The directed movement of a protein into a plasma membrane raft." [GOC:jl] is_a: GO:0032596 ! protein transport into membrane raft is_a: GO:0044860 ! protein localization to plasma membrane raft created_by: janelomax creation_date: 2014-07-23T16:26:29Z [Term] id: GO:0044862 name: protein transport out of plasma membrane raft namespace: biological_process def: "The directed movement of a protein out of a plasma membrane raft." [GOC:jl] is_a: GO:0032599 ! protein transport out of membrane raft is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:0099632 ! protein transport within plasma membrane is_a: GO:1990778 ! protein localization to cell periphery created_by: janelomax creation_date: 2014-07-23T16:32:56Z [Term] id: GO:0044863 name: modulation by virus of host cell division namespace: biological_process def: "Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells." [GOC:jl] synonym: "regulation by virus of host cell division" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0051302 ! regulation of cell division created_by: janelomax creation_date: 2014-08-05T16:30:03Z [Term] id: GO:0044864 name: positive regulation by virus of host cell division namespace: biological_process def: "Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division." [GOC:jl] is_a: GO:0044863 ! modulation by virus of host cell division is_a: GO:0051781 ! positive regulation of cell division created_by: janelomax creation_date: 2014-08-05T16:31:20Z [Term] id: GO:0044865 name: negative regulation by virus of host cell division namespace: biological_process def: "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division." [GOC:jl] synonym: "inhibition by virus of host cell division" NARROW [] is_a: GO:0044863 ! modulation by virus of host cell division is_a: GO:0051782 ! negative regulation of cell division created_by: janelomax creation_date: 2014-08-05T16:31:44Z [Term] id: GO:0044866 name: modulation by host of viral exo-alpha-sialidase activity namespace: biological_process def: "The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl] is_a: GO:0044867 ! modulation by host of viral catalytic activity is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity intersection_of: GO:0044867 ! modulation by host of viral catalytic activity intersection_of: regulates GO:0004308 ! exo-alpha-sialidase activity created_by: janelomax creation_date: 2014-09-18T11:28:18Z [Term] id: GO:0044867 name: modulation by host of viral catalytic activity namespace: biological_process def: "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected." [GOC:jl] is_a: GO:0044868 ! modulation by host of viral molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0044868 ! modulation by host of viral molecular function intersection_of: regulates GO:0003824 ! catalytic activity created_by: janelomax creation_date: 2014-09-18T11:29:25Z [Term] id: GO:0044868 name: modulation by host of viral molecular function namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected." [GOC:jl] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0044788 ! modulation by host of viral process intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: negatively_regulates GO:0003674 ! molecular_function created_by: janelomax creation_date: 2014-09-18T13:34:27Z [Term] id: GO:0044869 name: negative regulation by host of viral exo-alpha-sialidase activity namespace: biological_process def: "The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl] is_a: GO:0044866 ! modulation by host of viral exo-alpha-sialidase activity is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity is_a: GO:1903016 ! negative regulation of exo-alpha-sialidase activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity created_by: janelomax creation_date: 2014-09-18T14:13:51Z [Term] id: GO:0044870 name: modulation by host of viral glycoprotein metabolic process namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl] is_a: GO:0044788 ! modulation by host of viral process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0044788 ! modulation by host of viral process intersection_of: regulates GO:0009100 ! glycoprotein metabolic process created_by: janelomax creation_date: 2014-09-18T14:26:19Z [Term] id: GO:0044871 name: negative regulation by host of viral glycoprotein metabolic process namespace: biological_process def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl] is_a: GO:0044793 ! negative regulation by host of viral process is_a: GO:0044870 ! modulation by host of viral glycoprotein metabolic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process intersection_of: GO:0048525 ! negative regulation of viral process intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process created_by: janelomax creation_date: 2014-09-18T14:28:48Z [Term] id: GO:0044872 name: lipoprotein localization namespace: biological_process def: "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl] is_a: GO:0008104 ! protein localization created_by: janelomax creation_date: 2014-11-25T16:27:06Z [Term] id: GO:0044873 name: lipoprotein localization to membrane namespace: biological_process def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl] is_a: GO:0044872 ! lipoprotein localization is_a: GO:0072657 ! protein localization to membrane created_by: janelomax creation_date: 2014-11-25T16:28:43Z [Term] id: GO:0044874 name: lipoprotein localization to outer membrane namespace: biological_process def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl] is_a: GO:0044873 ! lipoprotein localization to membrane created_by: janelomax creation_date: 2014-11-25T16:30:30Z [Term] id: GO:0044875 name: gamma-glutamyl hercynylcysteine sulfoxide synthase namespace: molecular_function def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577] synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph] xref: EC:1.14.99 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: janelomax creation_date: 2014-12-15T11:44:54Z [Term] id: GO:0044876 name: hercynylselenocysteine synthase namespace: molecular_function def: "Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine." [GOC:jl, PMID:24828577] xref: MetaCyc:RXN-15803 xref: RHEA:42683 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: janelomax creation_date: 2014-12-15T11:56:12Z [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function alt_id: GO:0032403 def: "Interacting selectively and non-covalently with a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: GO:0005488 ! binding created_by: janelomax creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0044878 name: mitotic cytokinesis checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed." [GOC:jl, GOC:mtg_cell_cycle, PMID:17538026] synonym: "cytokinesis after mitosis checkpoint" RELATED [GOC:dph, GOC:vw] synonym: "defective cytokinesis checkpoint" RELATED [GOC:dph, GOC:vw] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle created_by: janelomax creation_date: 2015-01-13T15:30:23Z [Term] id: GO:0044879 name: morphogenesis checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth." [GOC:jl, GOC:mtg_cell_cycle] synonym: "septin checkpoint" EXACT [] is_a: GO:0007093 ! mitotic cell cycle checkpoint created_by: janelomax creation_date: 2015-01-13T16:03:07Z [Term] id: GO:0045002 name: double-strand break repair via single-strand annealing namespace: biological_process def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529] is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0045003 name: double-strand break repair via synthesis-dependent strand annealing namespace: biological_process def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] synonym: "mitotic gene conversion" RELATED [] synonym: "SDSA" BROAD [] is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0045004 name: DNA replication proofreading namespace: biological_process def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai] is_a: GO:0006281 ! DNA repair is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity [Term] id: GO:0045005 name: DNA-dependent DNA replication maintenance of fidelity namespace: biological_process def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of fidelity involved in DNA-dependent DNA replication" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0045006 name: DNA deamination namespace: biological_process def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai] is_a: GO:0006304 ! DNA modification [Term] id: GO:0045007 name: depurination namespace: biological_process def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai] xref: Wikipedia:Depurination is_a: GO:0006285 ! base-excision repair, AP site formation is_a: GO:0006304 ! DNA modification [Term] id: GO:0045008 name: depyrimidination namespace: biological_process def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai] is_a: GO:0006285 ! base-excision repair, AP site formation is_a: GO:0006304 ! DNA modification is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0045009 name: chitosome namespace: cellular_component def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0045010 name: actin nucleation namespace: biological_process def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] synonym: "actin filament nucleation" EXACT [] is_a: GO:0007015 ! actin filament organization is_a: GO:0030838 ! positive regulation of actin filament polymerization [Term] id: GO:0045012 name: obsolete MHC class II receptor activity namespace: molecular_function def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971] comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'. synonym: "class II major histocompatibility complex antigen" RELATED [] synonym: "major histocompatibility complex class II receptor" EXACT [] synonym: "MHC class II receptor activity" EXACT [] is_obsolete: true consider: GO:0032395 consider: GO:0042613 [Term] id: GO:0045013 name: carbon catabolite repression of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445] synonym: "carbon catabolite repression" RELATED [GOC:dph] synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0045990 ! carbon catabolite regulation of transcription is_a: GO:0061985 ! carbon catabolite repression [Term] id: GO:0045014 name: carbon catabolite repression of transcription by glucose namespace: biological_process def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [ISBN:0198506732, PMID:11018147] synonym: "down regulation of transcription by glucose" EXACT [] synonym: "down-regulation of transcription by glucose" EXACT [] synonym: "downregulation of transcription by glucose" EXACT [] synonym: "glucose effect" EXACT [] synonym: "glucose repression" EXACT [] synonym: "inhibition of transcription by glucose" NARROW [] is_a: GO:0045013 ! carbon catabolite repression of transcription is_a: GO:0061986 ! negative regulation of transcription by glucose [Term] id: GO:0045015 name: HDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759] synonym: "HDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0045016 name: mitochondrial magnesium ion transmembrane transport namespace: biological_process alt_id: GO:1990614 def: "The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai, PMID:11254124] synonym: "mitochondrial magnesium ion transport" RELATED [] is_a: GO:1903830 ! magnesium ion transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: mcc creation_date: 2015-01-21T17:44:38Z [Term] id: GO:0045017 name: glycerolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] synonym: "glycerolipid anabolism" EXACT [] synonym: "glycerolipid biosynthesis" EXACT [] synonym: "glycerolipid formation" EXACT [] synonym: "glycerolipid synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0045018 name: retrograde transport, vacuole to Golgi namespace: biological_process def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156] synonym: "retrograde transport from the vacuole" EXACT [] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0045019 name: negative regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "down regulation of nitric oxide biosynthetic process" EXACT [] synonym: "down-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "downregulation of nitric oxide biosynthetic process" EXACT [] synonym: "inhibition of nitric oxide biosynthetic process" NARROW [] synonym: "negative regulation of nitric oxide anabolism" EXACT [] synonym: "negative regulation of nitric oxide biosynthesis" EXACT [] synonym: "negative regulation of nitric oxide formation" EXACT [] synonym: "negative regulation of nitric oxide synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process is_a: GO:1904406 ! negative regulation of nitric oxide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045020 name: obsolete error-prone DNA repair namespace: biological_process def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974] comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. synonym: "error-prone DNA repair" EXACT [] synonym: "mutagenic DNA repair" EXACT [] is_obsolete: true consider: GO:0042276 [Term] id: GO:0045021 name: obsolete error-free DNA repair namespace: biological_process def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974] comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. synonym: "error-free DNA repair" EXACT [] is_obsolete: true consider: GO:0042275 consider: GO:0070987 [Term] id: GO:0045022 name: early endosome to late endosome transport namespace: biological_process def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194] is_a: GO:0016482 ! cytosolic transport is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments [Term] id: GO:0045023 name: G0 to G1 transition namespace: biological_process def: "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0045024 name: obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414] comment: This term was made obsolete because it represents a gene product. synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0045025 name: mitochondrial degradosome namespace: cellular_component def: "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834] synonym: "mtEXO" EXACT [PMID:10397341, PMID:9829834] is_a: GO:0000177 ! cytoplasmic exosome (RNase complex) is_a: GO:0098798 ! mitochondrial protein complex [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process alt_id: GO:0006947 def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0061025 ! membrane fusion [Term] id: GO:0045027 name: DNA end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] is_a: GO:0003677 ! DNA binding [Term] id: GO:0045028 name: G protein-coupled purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289] synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] synonym: "P2Y" RELATED [] synonym: "P2Y receptor" RELATED [PMID:9755289] synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] synonym: "purinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001608 ! G protein-coupled nucleotide receptor activity is_a: GO:0001614 ! purinergic nucleotide receptor activity relationship: part_of GO:0035589 ! G protein-coupled purinergic nucleotide receptor signaling pathway [Term] id: GO:0045029 name: UDP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah] is_a: GO:0015065 ! uridine nucleotide receptor activity [Term] id: GO:0045030 name: UTP-activated nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah] is_a: GO:0015065 ! uridine nucleotide receptor activity [Term] id: GO:0045031 name: ATP-activated adenosine receptor activity namespace: molecular_function def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP." [GOC:mah] synonym: "ATP-activated nucleotide receptor activity" BROAD [] is_a: GO:0001609 ! G protein-coupled adenosine receptor activity [Term] id: GO:0045032 name: ADP-activated adenosine receptor activity namespace: molecular_function def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP." [GOC:mah] synonym: "ADP-activated nucleotide receptor activity" BROAD [] is_a: GO:0001609 ! G protein-coupled adenosine receptor activity [Term] id: GO:0045033 name: peroxisome inheritance namespace: biological_process def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545] comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. is_a: GO:0007031 ! peroxisome organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0045034 name: obsolete neuroblast division namespace: biological_process alt_id: GO:0043345 alt_id: GO:0043346 def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167] comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division. synonym: "neuroblast cell division" EXACT [] synonym: "neuroblast division" EXACT [] synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT [] synonym: "neuroblast division (sensu Vertebrata)" EXACT [] is_obsolete: true [Term] id: GO:0045035 name: sensory organ precursor cell division namespace: biological_process def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] synonym: "sense organ precursor cell division" EXACT [GOC:dph] is_a: GO:0008356 ! asymmetric cell division relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0045036 name: protein targeting to chloroplast namespace: biological_process def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363] synonym: "protein-chloroplast targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0072596 ! establishment of protein localization to chloroplast [Term] id: GO:0045037 name: protein import into chloroplast stroma namespace: biological_process def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] synonym: "chloroplast stroma protein import" EXACT [] synonym: "protein transport into chloroplast stroma" EXACT [] is_a: GO:0017038 ! protein import is_a: GO:0045036 ! protein targeting to chloroplast is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0045038 name: protein import into chloroplast thylakoid membrane namespace: biological_process def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363] synonym: "chloroplast thylakoid membrane protein import" EXACT [] synonym: "protein transport into chloroplast thylakoid membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0045036 ! protein targeting to chloroplast is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0045039 name: protein insertion into mitochondrial inner membrane namespace: biological_process def: "The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008] synonym: "mitochondrial inner membrane protein import" EXACT [] synonym: "protein import into mitochondrial inner membrane" EXACT [] synonym: "protein transport into mitochondrial inner membrane" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0006886 ! intracellular protein transport is_a: GO:0007007 ! inner mitochondrial membrane organization is_a: GO:0051204 ! protein insertion into mitochondrial membrane is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0045040 name: protein insertion into mitochondrial outer membrane namespace: biological_process def: "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008] synonym: "mitochondrial outer membrane protein import" EXACT [] synonym: "protein import into mitochondrial outer membrane" EXACT [] synonym: "protein transport into mitochondrial outer membrane" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0006886 ! intracellular protein transport is_a: GO:0007008 ! outer mitochondrial membrane organization is_a: GO:0017038 ! protein import is_a: GO:0051204 ! protein insertion into mitochondrial membrane is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane relationship: occurs_in GO:0005737 ! cytoplasm relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0045041 name: protein import into mitochondrial intermembrane space namespace: biological_process alt_id: GO:0045043 alt_id: GO:0045044 def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] synonym: "mitochondrial intermembrane space protein import" EXACT [] synonym: "protein import into mitochondrial IMS" EXACT [] synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc] synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc] synonym: "protein transport into mitochondrial IMS" EXACT [] synonym: "protein transport into mitochondrial intermembrane space" EXACT [] is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0065002 ! intracellular protein transmembrane transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:1990542 ! mitochondrial transmembrane transport relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0045042 name: obsolete protein import into mitochondrial intermembrane space, conservative namespace: biological_process def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363] comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space. synonym: "conservative mitochondrial IMS protein import" EXACT [] synonym: "conservative mitochondrial intermembrane space protein import" EXACT [] synonym: "conservative protein transport into mitochondrial IMS" EXACT [] synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT [] synonym: "protein import into mitochondrial IMS, conservative" EXACT [] synonym: "protein import into mitochondrial intermembrane space, conservative" EXACT [] synonym: "protein transport into mitochondrial IMS, conservative" EXACT [] synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT [] is_obsolete: true consider: GO:0045039 consider: GO:0045041 [Term] id: GO:0045045 name: obsolete secretory pathway namespace: biological_process def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363] comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations. synonym: "secretory pathway" EXACT [] is_obsolete: true replaced_by: GO:0032940 [Term] id: GO:0045046 name: protein import into peroxisome membrane namespace: biological_process def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502] synonym: "peroxisome membrane protein import" EXACT [] synonym: "protein transport into peroxisome membrane" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0006625 ! protein targeting to peroxisome is_a: GO:0015919 ! peroxisomal membrane transport is_a: GO:0017038 ! protein import [Term] id: GO:0045047 name: protein targeting to ER namespace: biological_process def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363] synonym: "protein targeting to endoplasmic reticulum" EXACT [] synonym: "protein-endoplasmic reticulum targeting" EXACT [] synonym: "protein-ER targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum [Term] id: GO:0045048 name: protein insertion into ER membrane namespace: biological_process def: "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363] synonym: "integral ER membrane protein localization" EXACT [] synonym: "integral ER membrane protein positioning" EXACT [] synonym: "localization of protein in ER membrane" EXACT [] synonym: "positioning of protein in ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane" EXACT [] synonym: "protein-endoplasmic reticulum insertion" EXACT [] synonym: "protein-ER insertion" EXACT [] is_a: GO:0051205 ! protein insertion into membrane relationship: part_of GO:0007029 ! endoplasmic reticulum organization relationship: part_of GO:0033365 ! protein localization to organelle [Term] id: GO:0045049 name: protein insertion into ER membrane by N-terminal cleaved signal sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363] synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT [] synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT [] synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045050 name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363] synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT [] synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT [] synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT [] synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045051 name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363] synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT [] synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT [] synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045052 name: protein insertion into ER membrane by GPI attachment sequence namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363] synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT [] synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT [] synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT [] synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT [] synonym: "protein-ER insertion by GPI attachment sequence" EXACT [] is_a: GO:0045048 ! protein insertion into ER membrane [Term] id: GO:0045053 name: protein retention in Golgi apparatus namespace: biological_process def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363] synonym: "maintenance of protein location in Golgi apparatus" RELATED [] synonym: "protein-Golgi retention" EXACT [] synonym: "retention of protein in Golgi" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0034067 ! protein localization to Golgi apparatus [Term] id: GO:0045054 name: constitutive secretory pathway namespace: biological_process def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363] synonym: "constitutive exocytosis" EXACT [] is_a: GO:0006887 ! exocytosis [Term] id: GO:0045055 name: regulated exocytosis namespace: biological_process def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363] synonym: "regulated secretory pathway" EXACT [] is_a: GO:0006887 ! exocytosis [Term] id: GO:0045056 name: transcytosis namespace: biological_process def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363] xref: Wikipedia:Transcytosis is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0045057 name: cisternal progression namespace: biological_process def: "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363] synonym: "cisternal maturation" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0045058 name: T cell selection namespace: biological_process def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722] synonym: "T lymphocyte selection" EXACT [] synonym: "T-cell selection" EXACT [] synonym: "T-lymphocyte selection" EXACT [] xref: Wikipedia:Thymocyte is_a: GO:0002376 ! immune system process relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0045059 name: positive thymic T cell selection namespace: biological_process def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722] synonym: "positive thymic T lymphocyte selection" EXACT [] synonym: "positive thymic T-cell selection" EXACT [] synonym: "positive thymic T-lymphocyte selection" EXACT [] is_a: GO:0043368 ! positive T cell selection is_a: GO:0045061 ! thymic T cell selection [Term] id: GO:0045060 name: negative thymic T cell selection namespace: biological_process def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722] synonym: "negative thymic T lymphocyte selection" EXACT [] synonym: "negative thymic T-cell selection" EXACT [] synonym: "negative thymic T-lymphocyte selection" EXACT [] is_a: GO:0043383 ! negative T cell selection is_a: GO:0045061 ! thymic T cell selection [Term] id: GO:0045061 name: thymic T cell selection namespace: biological_process def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149, PMID:12414722] synonym: "thymic T lymphocyte selection" EXACT [] synonym: "thymic T-cell selection" EXACT [] synonym: "thymic T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0045062 name: extrathymic T cell selection namespace: biological_process def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149, PMID:7880383] synonym: "extrathymic T lymphocyte selection" EXACT [] synonym: "extrathymic T-cell selection" EXACT [] synonym: "extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection relationship: part_of GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0045063 name: T-helper 1 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0045064 name: T-helper 2 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0042092 ! type 2 immune response [Term] id: GO:0045065 name: cytotoxic T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "cytotoxic T cell development" RELATED [GOC:add] synonym: "cytotoxic T lymphocyte selection" EXACT [] synonym: "cytotoxic T-cell selection" EXACT [] synonym: "cytotoxic T-lymphocyte selection" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0045066 name: regulatory T cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulatory T cell development" RELATED [GOC:add] synonym: "regulatory T lymphocyte differentiation" EXACT [] synonym: "regulatory T-cell differentiation" EXACT [] synonym: "regulatory T-lymphocyte differentiation" EXACT [] synonym: "suppressor T cell differentiation" EXACT [] synonym: "suppressor T lymphocyte differentiation" EXACT [] synonym: "suppressor T-cell differentiation" EXACT [] synonym: "suppressor T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0045067 name: positive extrathymic T cell selection namespace: biological_process def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:7880383] synonym: "positive extrathymic T cell selection" RELATED [GOC:add] synonym: "positive extrathymic T lymphocyte selection" EXACT [] synonym: "positive extrathymic T-cell selection" EXACT [] synonym: "positive extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0043368 ! positive T cell selection is_a: GO:0045062 ! extrathymic T cell selection [Term] id: GO:0045068 name: negative extrathymic T cell selection namespace: biological_process def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:7880383] synonym: "negative extrathymic T lymphocyte selection" EXACT [] synonym: "negative extrathymic T-cell selection" EXACT [] synonym: "negative extrathymic T-lymphocyte selection" EXACT [] is_a: GO:0043383 ! negative T cell selection is_a: GO:0045062 ! extrathymic T cell selection [Term] id: GO:0045069 name: regulation of viral genome replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai] is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019079 ! viral genome replication relationship: regulates GO:0019079 ! viral genome replication [Term] id: GO:0045070 name: positive regulation of viral genome replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai] synonym: "activation of viral genome replication" NARROW [] synonym: "stimulation of viral genome replication" NARROW [] synonym: "up regulation of viral genome replication" EXACT [] synonym: "up-regulation of viral genome replication" EXACT [] synonym: "upregulation of viral genome replication" EXACT [] is_a: GO:0045069 ! regulation of viral genome replication is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019079 ! viral genome replication relationship: positively_regulates GO:0019079 ! viral genome replication [Term] id: GO:0045071 name: negative regulation of viral genome replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators] synonym: "down regulation of viral genome replication" EXACT [] synonym: "down-regulation of viral genome replication" EXACT [] synonym: "downregulation of viral genome replication" EXACT [] synonym: "inhibition of viral genome replication" NARROW [] is_a: GO:0045069 ! regulation of viral genome replication is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019079 ! viral genome replication relationship: negatively_regulates GO:0019079 ! viral genome replication [Term] id: GO:0045072 name: regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "regulation of interferon-gamma anabolism" EXACT [] synonym: "regulation of interferon-gamma biosynthesis" EXACT [] synonym: "regulation of interferon-gamma formation" EXACT [] synonym: "regulation of interferon-gamma synthesis" EXACT [] is_a: GO:0032649 ! regulation of interferon-gamma production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042095 ! interferon-gamma biosynthetic process relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045073 name: regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "regulation of chemokine anabolism" EXACT [] synonym: "regulation of chemokine biosynthesis" EXACT [] synonym: "regulation of chemokine formation" EXACT [] synonym: "regulation of chemokine synthesis" EXACT [] is_a: GO:0032642 ! regulation of chemokine production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042033 ! chemokine biosynthetic process relationship: regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045074 name: regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "regulation of IL-10 biosynthesis" EXACT [] synonym: "regulation of IL-10 biosynthetic process" EXACT [] synonym: "regulation of interleukin-10 anabolism" EXACT [] synonym: "regulation of interleukin-10 biosynthesis" EXACT [] synonym: "regulation of interleukin-10 formation" EXACT [] synonym: "regulation of interleukin-10 synthesis" EXACT [] is_a: GO:0032653 ! regulation of interleukin-10 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042091 ! interleukin-10 biosynthetic process relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045075 name: regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "regulation of IL-12 biosynthesis" EXACT [] synonym: "regulation of IL-12 biosynthetic process" EXACT [] synonym: "regulation of interleukin-12 anabolism" EXACT [] synonym: "regulation of interleukin-12 biosynthesis" EXACT [] synonym: "regulation of interleukin-12 formation" EXACT [] synonym: "regulation of interleukin-12 synthesis" EXACT [] is_a: GO:0032655 ! regulation of interleukin-12 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042090 ! interleukin-12 biosynthetic process relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045076 name: regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "regulation of IL-2 biosynthesis" EXACT [] synonym: "regulation of IL-2 biosynthetic process" EXACT [] synonym: "regulation of interleukin-2 anabolism" EXACT [] synonym: "regulation of interleukin-2 biosynthesis" EXACT [] synonym: "regulation of interleukin-2 formation" EXACT [] synonym: "regulation of interleukin-2 synthesis" EXACT [] is_a: GO:0032663 ! regulation of interleukin-2 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042094 ! interleukin-2 biosynthetic process relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045077 name: negative regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "down regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "downregulation of interferon-gamma biosynthetic process" EXACT [] synonym: "inhibition of interferon-gamma biosynthetic process" NARROW [] synonym: "negative regulation of interferon-gamma anabolism" EXACT [] synonym: "negative regulation of interferon-gamma biosynthesis" EXACT [] synonym: "negative regulation of interferon-gamma formation" EXACT [] synonym: "negative regulation of interferon-gamma synthesis" EXACT [] is_a: GO:0032689 ! negative regulation of interferon-gamma production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045078 name: positive regulation of interferon-gamma biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] synonym: "activation of interferon-gamma biosynthetic process" NARROW [] synonym: "positive regulation of interferon-gamma anabolism" EXACT [] synonym: "positive regulation of interferon-gamma biosynthesis" EXACT [] synonym: "positive regulation of interferon-gamma formation" EXACT [] synonym: "positive regulation of interferon-gamma synthesis" EXACT [] synonym: "stimulation of interferon-gamma biosynthetic process" NARROW [] synonym: "up regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT [] synonym: "upregulation of interferon-gamma biosynthetic process" EXACT [] is_a: GO:0032729 ! positive regulation of interferon-gamma production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process [Term] id: GO:0045079 name: negative regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "down regulation of chemokine biosynthetic process" EXACT [] synonym: "down-regulation of chemokine biosynthetic process" EXACT [] synonym: "downregulation of chemokine biosynthetic process" EXACT [] synonym: "inhibition of chemokine biosynthetic process" NARROW [] synonym: "negative regulation of chemokine anabolism" EXACT [] synonym: "negative regulation of chemokine biosynthesis" EXACT [] synonym: "negative regulation of chemokine formation" EXACT [] synonym: "negative regulation of chemokine synthesis" EXACT [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045073 ! regulation of chemokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042033 ! chemokine biosynthetic process relationship: negatively_regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045080 name: positive regulation of chemokine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] synonym: "activation of chemokine biosynthetic process" NARROW [] synonym: "positive regulation of chemokine anabolism" EXACT [] synonym: "positive regulation of chemokine biosynthesis" EXACT [] synonym: "positive regulation of chemokine formation" EXACT [] synonym: "positive regulation of chemokine synthesis" EXACT [] synonym: "stimulation of chemokine biosynthetic process" NARROW [] synonym: "up regulation of chemokine biosynthetic process" EXACT [] synonym: "up-regulation of chemokine biosynthetic process" EXACT [] synonym: "upregulation of chemokine biosynthetic process" EXACT [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045073 ! regulation of chemokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042033 ! chemokine biosynthetic process relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process [Term] id: GO:0045081 name: negative regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "down regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-10 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-10 biosynthetic process" NARROW [] synonym: "negative regulation of IL-10 biosynthesis" EXACT [] synonym: "negative regulation of IL-10 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-10 anabolism" EXACT [] synonym: "negative regulation of interleukin-10 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-10 formation" EXACT [] synonym: "negative regulation of interleukin-10 synthesis" EXACT [] is_a: GO:0032693 ! negative regulation of interleukin-10 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045082 name: positive regulation of interleukin-10 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] synonym: "activation of interleukin-10 biosynthetic process" NARROW [] synonym: "positive regulation of IL-10 biosynthesis" EXACT [] synonym: "positive regulation of IL-10 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-10 anabolism" EXACT [] synonym: "positive regulation of interleukin-10 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-10 formation" EXACT [] synonym: "positive regulation of interleukin-10 synthesis" EXACT [] synonym: "stimulation of interleukin-10 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-10 biosynthetic process" EXACT [] is_a: GO:0032733 ! positive regulation of interleukin-10 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process [Term] id: GO:0045083 name: negative regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "down regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-12 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-12 biosynthetic process" NARROW [] synonym: "negative regulation of IL-12 biosynthesis" EXACT [] synonym: "negative regulation of IL-12 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-12 anabolism" EXACT [] synonym: "negative regulation of interleukin-12 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-12 formation" EXACT [] synonym: "negative regulation of interleukin-12 synthesis" EXACT [] is_a: GO:0032695 ! negative regulation of interleukin-12 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045084 name: positive regulation of interleukin-12 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] synonym: "activation of interleukin-12 biosynthetic process" NARROW [] synonym: "positive regulation of IL-12 biosynthesis" EXACT [] synonym: "positive regulation of IL-12 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-12 anabolism" EXACT [] synonym: "positive regulation of interleukin-12 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-12 formation" EXACT [] synonym: "positive regulation of interleukin-12 synthesis" EXACT [] synonym: "stimulation of interleukin-12 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-12 biosynthetic process" EXACT [] is_a: GO:0032735 ! positive regulation of interleukin-12 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process [Term] id: GO:0045085 name: negative regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "down regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-2 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-2 biosynthetic process" NARROW [] synonym: "negative regulation of IL-2 biosynthesis" EXACT [] synonym: "negative regulation of IL-2 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-2 anabolism" EXACT [] synonym: "negative regulation of interleukin-2 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-2 formation" EXACT [] synonym: "negative regulation of interleukin-2 synthesis" EXACT [] is_a: GO:0032703 ! negative regulation of interleukin-2 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045086 name: positive regulation of interleukin-2 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] synonym: "activation of interleukin-2 biosynthetic process" NARROW [] synonym: "positive regulation of IL-2 biosynthesis" EXACT [] synonym: "positive regulation of IL-2 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-2 anabolism" EXACT [] synonym: "positive regulation of interleukin-2 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-2 formation" EXACT [] synonym: "positive regulation of interleukin-2 synthesis" EXACT [] synonym: "stimulation of interleukin-2 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-2 biosynthetic process" EXACT [] is_a: GO:0032743 ! positive regulation of interleukin-2 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process [Term] id: GO:0045087 name: innate immune response namespace: biological_process alt_id: GO:0002226 def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "innate immunity" EXACT [GOC:pg] synonym: "nonspecific immune response" EXACT [] xref: MIPS_funcat:36.25.16.01 xref: Wikipedia:Innate_immune_system is_a: GO:0006955 ! immune response is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0045088 name: regulation of innate immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045087 ! innate immune response relationship: regulates GO:0045087 ! innate immune response [Term] id: GO:0045089 name: positive regulation of innate immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] synonym: "stimulation of innate immune response" NARROW [] synonym: "up regulation of innate immune response" EXACT [] synonym: "up-regulation of innate immune response" EXACT [] synonym: "upregulation of innate immune response" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045087 ! innate immune response relationship: positively_regulates GO:0045087 ! innate immune response [Term] id: GO:0045091 name: regulation of single stranded viral RNA replication via double stranded DNA intermediate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators] synonym: "regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] is_a: GO:0045069 ! regulation of viral genome replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate relationship: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate [Term] id: GO:0045092 name: interleukin-18 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435] synonym: "IL-18 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0045093 name: obsolete interleukin-18 alpha subunit binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850] comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits synonym: "IL-18Ra binding" EXACT [] is_obsolete: true [Term] id: GO:0045094 name: obsolete interleukin-18 beta subunit binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850] comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits. synonym: "IL-18Rb binding" EXACT [] is_obsolete: true [Term] id: GO:0045095 name: keratin filament namespace: cellular_component def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] synonym: "acidic keratin" RELATED [] synonym: "basic/neutral keratin" RELATED [] is_a: GO:0005882 ! intermediate filament [Term] id: GO:0045096 name: obsolete acidic keratin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. synonym: "acidic keratin" EXACT [] synonym: "type I intermediate filament" EXACT [] is_obsolete: true replaced_by: GO:0045095 [Term] id: GO:0045097 name: obsolete basic/neutral keratin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. synonym: "basic/neutral keratin" EXACT [] synonym: "type II intermediate filament" EXACT [] is_obsolete: true replaced_by: GO:0045095 [Term] id: GO:0045098 name: type III intermediate filament namespace: cellular_component def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363] synonym: "desmin" NARROW [] synonym: "glial fibrillary acidic protein" NARROW [] synonym: "peripherin" NARROW [] synonym: "type III intermediate filament associated protein" NARROW [] synonym: "vimentin" NARROW [] is_a: GO:0005882 ! intermediate filament [Term] id: GO:0045099 name: obsolete vimentin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. synonym: "vimentin" EXACT [] is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0045100 name: obsolete desmin namespace: cellular_component def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194] comment: This term was made obsolete because it represents a gene product. synonym: "desmin" EXACT [] is_obsolete: true consider: GO:0045098 [Term] id: GO:0045101 name: obsolete glial fibrillary acidic protein namespace: cellular_component def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. synonym: "GFAP" EXACT [] synonym: "glial fibrillary acidic protein" EXACT [] is_obsolete: true consider: GO:0045098 [Term] id: GO:0045102 name: obsolete peripherin namespace: cellular_component def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363] comment: This term was made obsolete because it represents a gene product. synonym: "peripherin" EXACT [] is_obsolete: true consider: GO:0045098 [Term] id: GO:0045103 name: intermediate filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] is_a: GO:0009987 ! cellular process [Term] id: GO:0045104 name: intermediate filament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] synonym: "intermediate filament cytoskeleton organisation" EXACT [] synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.04.07 is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0045103 ! intermediate filament-based process [Term] id: GO:0045105 name: intermediate filament polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai] is_a: GO:0043933 ! protein-containing complex subunit organization relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization [Term] id: GO:0045106 name: intermediate filament depolymerization namespace: biological_process def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363] is_a: GO:0045105 ! intermediate filament polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0045107 name: intermediate filament polymerization namespace: biological_process def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884] is_a: GO:0045105 ! intermediate filament polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0045108 name: regulation of intermediate filament polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363] is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045105 ! intermediate filament polymerization or depolymerization relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization [Term] id: GO:0045109 name: intermediate filament organization namespace: biological_process def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] synonym: "intermediate filament organisation" EXACT [] is_a: GO:0045104 ! intermediate filament cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0045110 name: intermediate filament bundle assembly namespace: biological_process def: "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363] synonym: "tonofilament assembly" NARROW [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0045109 ! intermediate filament organization [Term] id: GO:0045111 name: intermediate filament cytoskeleton namespace: cellular_component def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] xref: MIPS_funcat:70.04.07 is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0045112 name: integrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732] synonym: "integrin anabolism" EXACT [] synonym: "integrin biosynthesis" EXACT [] synonym: "integrin formation" EXACT [] synonym: "integrin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0007009 ! plasma membrane organization [Term] id: GO:0045113 name: regulation of integrin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "regulation of integrin anabolism" EXACT [] synonym: "regulation of integrin biosynthesis" EXACT [] synonym: "regulation of integrin formation" EXACT [] synonym: "regulation of integrin synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045112 ! integrin biosynthetic process relationship: regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045114 name: beta 2 integrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators] synonym: "beta 2 integrin anabolism" EXACT [] synonym: "beta 2 integrin biosynthesis" EXACT [] synonym: "beta 2 integrin formation" EXACT [] synonym: "beta 2 integrin synthesis" EXACT [] is_a: GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045115 name: regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "regulation of beta 2 integrin anabolism" EXACT [] synonym: "regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "regulation of beta 2 integrin formation" EXACT [] synonym: "regulation of beta 2 integrin synthesis" EXACT [] is_a: GO:0045113 ! regulation of integrin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045114 ! beta 2 integrin biosynthetic process relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045116 name: protein neddylation namespace: biological_process alt_id: GO:0019943 def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] comment: Note that currently, the only known substrates of neddylation are cullin family proteins. synonym: "RUB1-protein conjugation" EXACT [] xref: MIPS_funcat:14.07.07 is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0045117 name: azole transmembrane transport namespace: biological_process def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] synonym: "azole transport" RELATED [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0045119 name: azole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole] synonym: "azole:hydrogen antiporter activity" EXACT [] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:1901474 ! azole transmembrane transporter activity [Term] id: GO:0045120 name: pronucleus namespace: cellular_component def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732] xref: Wikipedia:Pronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0045121 name: membrane raft namespace: cellular_component def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] synonym: "GEM domain" RELATED [] synonym: "glycolipid-enriched membrane domain" RELATED [] synonym: "lipid raft" EXACT [] xref: Wikipedia:Lipid_raft is_a: GO:0098857 ! membrane microdomain [Term] id: GO:0045122 name: aflatoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194] synonym: "aflatoxin anabolism" EXACT [] synonym: "aflatoxin biosynthesis" EXACT [] synonym: "aflatoxin formation" EXACT [] synonym: "aflatoxin synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046222 ! aflatoxin metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process relationship: has_part GO:0042469 ! versicolorin reductase activity relationship: has_part GO:0046572 ! versicolorin B synthase activity relationship: has_part GO:0047145 ! demethylsterigmatocystin 6-O-methyltransferase activity relationship: has_part GO:0047146 ! sterigmatocystin 7-O-methyltransferase activity relationship: has_part GO:0102973 ! norsolorinate anthrone synthase activity relationship: has_part GO:0140393 ! norsolorinic acid ketoreductase activity relationship: has_part GO:0140395 ! averantin hydroxylase activity relationship: has_part GO:0140396 ! 5'-hydroxyaverantin dehydrogenase activity relationship: has_part GO:0140397 ! versiconal hemiacetal acetate esterase activity relationship: has_part GO:0140398 ! versicolorin B desaturase activity [Term] id: GO:0045123 name: cellular extravasation namespace: biological_process def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl] synonym: "immune cell cellular extravasation" EXACT [] synonym: "leucocyte cellular extravasation" EXACT [] synonym: "leukocyte cellular extravasation" EXACT [] synonym: "transendothelial leukocyte migration" EXACT [GOC:rl] xref: Wikipedia:Leukocyte_extravasation is_a: GO:0050900 ! leukocyte migration [Term] id: GO:0045124 name: regulation of bone resorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] is_a: GO:0046850 ! regulation of bone remodeling is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045453 ! bone resorption relationship: regulates GO:0045453 ! bone resorption [Term] id: GO:0045125 name: bioactive lipid receptor activity namespace: molecular_function def: "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0045127 name: N-acetylglucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17417] synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59] synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59] synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59] synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59] synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59] xref: EC:2.7.1.59 xref: KEGG_REACTION:R01201 xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN xref: Reactome:R-HSA-6803771 "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P" xref: RHEA:17417 is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0045128 name: negative regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of meiotic recombination" EXACT [] synonym: "down-regulation of meiotic recombination" EXACT [] synonym: "downregulation of meiotic recombination" EXACT [] synonym: "inhibition of meiotic recombination" NARROW [] synonym: "suppression of meiotic recombination" EXACT [] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0110029 ! negative regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007131 ! reciprocal meiotic recombination relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0045129 name: NAD-independent histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24548] synonym: "AcuC" RELATED [] is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0045130 name: keratan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21] synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT [] synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21] synonym: "keratan sulphotransferase activity" EXACT [] xref: EC:2.8.2.21 xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-2046175 "Further sulfation on galactose residues produces KSPG" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0045131 name: pre-mRNA branch point binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632] is_a: GO:0036002 ! pre-mRNA binding [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division [Term] id: GO:0045133 name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.14, RHEA:18477] synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14] synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14] synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14] xref: EC:1.13.11.14 xref: KEGG_REACTION:R01507 xref: MetaCyc:1.13.11.14-RXN xref: RHEA:18477 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0045134 name: uridine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] synonym: "UDP phosphohydrolase activity" EXACT [KEGG_REACTION:R00155] synonym: "UDPase activity" EXACT [EC:3.6.1.6] synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6] xref: EC:3.6.1.6 xref: KEGG_REACTION:R00155 xref: MetaCyc:RXN-12197 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0045135 name: poly(beta-D-mannuronate) lyase activity namespace: molecular_function def: "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3] synonym: "alginase activity" EXACT [EC:4.2.2.3] synonym: "alginase I" RELATED [EC:4.2.2.3] synonym: "alginate lyase activity" EXACT [EC:4.2.2.3] synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3] synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3] synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3] xref: EC:4.2.2.3 xref: MetaCyc:4.2.2.3-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0045136 name: development of secondary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0045137 name: development of primary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007275 ! multicellular organism development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0045138 name: nematode male tail tip morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome." [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314] synonym: "male tail morphogenesis" BROAD [] synonym: "male tail tip morphogenesis" RELATED [GOC:kmv] synonym: "tail tip morphogenesis" RELATED [GOC:kmv] is_a: GO:0090598 ! male anatomical structure morphogenesis [Term] id: GO:0045139 name: obsolete copper sensitivity/resistance namespace: biological_process def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "copper sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046688 [Term] id: GO:0045140 name: inositol phosphoceramide synthase activity namespace: molecular_function def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099] synonym: "IPC synthase activity" EXACT [] xref: MetaCyc:RXN3O-581 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0045141 name: meiotic telomere clustering namespace: biological_process def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419] synonym: "bouquet biosynthesis" NARROW [] synonym: "bouquet formation" NARROW [] is_a: GO:0034397 ! telomere localization is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:0090220 ! chromosome localization to nuclear envelope involved in homologous chromosome segregation [Term] id: GO:0045142 name: triplex DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538] is_a: GO:0003677 ! DNA binding [Term] id: GO:0045143 name: homologous chromosome segregation namespace: biological_process alt_id: GO:0007061 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] synonym: "meiosis I, chromosome segregation" EXACT [] is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007127 ! meiosis I relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0000819 ! sister chromatid segregation intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0045145 name: single-stranded DNA 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101] synonym: "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0045146 name: initiation of acetate catabolic process by acetate namespace: biological_process def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859] synonym: "initiation of acetate breakdown by acetate" EXACT [] synonym: "initiation of acetate degradation by acetate" EXACT [] is_a: GO:0043077 ! initiation of acetate catabolic process relationship: part_of GO:0010034 ! response to acetate [Term] id: GO:0045147 name: regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "regulation of initiation of acetate degradation by acetate" EXACT [] is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:1901457 ! regulation of response to acetate intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045146 ! initiation of acetate catabolic process by acetate relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045148 name: tripeptide aminopeptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4] synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4] synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4] synonym: "aminotripeptidase activity" EXACT [] synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4] synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4] synonym: "peptidase B" RELATED [EC:3.4.11.4] synonym: "peptidase T" EXACT [] xref: EC:3.4.11.4 xref: MetaCyc:3.4.11.4-RXN is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0034701 ! tripeptidase activity [Term] id: GO:0045149 name: acetoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg] synonym: "acetoin metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0045150 name: acetoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] synonym: "acetoin breakdown" EXACT [] synonym: "acetoin catabolism" EXACT [] synonym: "acetoin degradation" EXACT [] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0045149 ! acetoin metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0045151 name: acetoin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] synonym: "acetoin anabolism" EXACT [] synonym: "acetoin biosynthesis" EXACT [] synonym: "acetoin formation" EXACT [] synonym: "acetoin synthesis" EXACT [] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0045149 ! acetoin metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0045152 name: antisigma factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg] synonym: "antisigma factor antagonist activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0045153 name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome b562" NARROW [] synonym: "cytochrome b566" NARROW [] synonym: "cytochrome c1" NARROW [] synonym: "soluble cytochrome b562" RELATED [] xref: Reactome:R-HSA-164651 "Electron transfer from ubiquinol to cytochrome c of complex III" is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045154 name: electron transporter, transferring electrons within cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome a" NARROW [] synonym: "cytochrome a3/copper complex" NARROW [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045155 name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity namespace: molecular_function def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome c" NARROW [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045156 name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome bc1 complex" NARROW [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045157 name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity namespace: molecular_function def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045158 name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] synonym: "cytochrome" RELATED [] synonym: "cytochrome b/b6" RELATED [] synonym: "cytochrome b6" NARROW [] synonym: "cytochrome f" NARROW [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0045159 name: myosin II binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0045160 name: myosin I complex namespace: cellular_component def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0045161 name: neuronal ion channel clustering namespace: biological_process def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0042551 ! neuron maturation [Term] id: GO:0045162 name: clustering of voltage-gated sodium channels namespace: biological_process def: "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440] synonym: "clustering of voltage gated sodium channels" EXACT [] synonym: "clustering of voltage-dependent sodium channels" EXACT [] synonym: "Nav channel clustering" EXACT [] synonym: "voltage-gated sodium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0045163 name: clustering of voltage-gated potassium channels namespace: biological_process def: "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440] synonym: "clustering of voltage gated potassium channels" EXACT [] synonym: "clustering of voltage-dependent potassium channels" EXACT [] synonym: "Kv channel clustering" EXACT [] synonym: "voltage-gated potassium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0045164 name: obsolete secretin (sensu Mammalia) namespace: molecular_function def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551] comment: This term was made obsolete because it represents a gene product rather than a molecular function. synonym: "secretin (sensu Mammalia)" EXACT [] is_obsolete: true consider: GO:0046659 [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0045167 name: asymmetric protein localization involved in cell fate determination namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] synonym: "asymmetric protein localisation involved in cell fate determination" EXACT [GOC:mah] synonym: "asymmetric protein localization involved in cell fate commitment" EXACT [] synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT [] synonym: "cell fate commitment, asymmetric protein localization" EXACT [] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0001709 ! cell fate determination relationship: part_of GO:0001709 ! cell fate determination [Term] id: GO:0045168 name: cell-cell signaling involved in cell fate commitment namespace: biological_process def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell fate commitment, cell-cell signaling" EXACT [] synonym: "cell fate commitment, cell-cell signalling" EXACT [] synonym: "cell-cell signaling during in cell fate commitment" EXACT [] synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] synonym: "cell-cell signalling during cell fate commitment" EXACT [] synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0045165 ! cell fate commitment relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0045169 name: fusome namespace: cellular_component def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045170 name: spectrosome namespace: cellular_component def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045171 name: intercellular bridge namespace: cellular_component def: "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0045172 name: germline ring canal namespace: cellular_component def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] is_a: GO:0045171 ! intercellular bridge [Term] id: GO:0045173 name: O-sialoglycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323] synonym: "O-sialoglycoprotein breakdown" EXACT [] synonym: "O-sialoglycoprotein catabolism" EXACT [] synonym: "O-sialoglycoprotein degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0045174 name: glutathione dehydrogenase (ascorbate) activity namespace: molecular_function def: "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24424] synonym: "dehydroascorbate reductase activity" EXACT [] synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1] synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1] synonym: "DHA reductase activity" EXACT [EC:1.8.5.1] synonym: "GDOR" RELATED [EC:1.8.5.1] synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1] synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1] xref: EC:1.8.5.1 xref: KEGG_REACTION:R01108 xref: MetaCyc:1.8.5.1-RXN xref: Reactome:R-HSA-198813 "2xGSTOs reduce DHvitC to VitC" xref: RHEA:24424 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0045175 name: basal protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] synonym: "basal protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of basal protein localization" EXACT [] synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT [] is_a: GO:0008104 ! protein localization [Term] id: GO:0045176 name: apical protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] synonym: "apical protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of apical protein localization" EXACT [] synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT [] is_a: GO:0008104 ! protein localization [Term] id: GO:0045177 name: apical part of cell namespace: cellular_component def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "apical region of cell" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0045178 name: basal part of cell namespace: cellular_component def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] subset: goslim_pir is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0045179 name: apical cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0045177 ! apical part of cell relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0045180 name: basal cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0045178 ! basal part of cell relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0045181 name: glutamate synthase activity, NAD(P)H as acceptor namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14] synonym: "glutamate synthase activity, NADH or NADPH as acceptor" RELATED [] is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0045182 name: translation regulator activity namespace: molecular_function def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "translation factor activity" EXACT [] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: part_of GO:0006417 ! regulation of translation relationship: part_of GO:0006417 ! regulation of translation [Term] id: GO:0045183 name: translation factor activity, non-nucleic acid binding namespace: molecular_function def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization [Term] id: GO:0045185 name: maintenance of protein location namespace: biological_process def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] synonym: "active protein retrieval" NARROW [] synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] synonym: "protein retention" NARROW [] synonym: "protein sequestering" NARROW [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0008104 ! protein localization [Term] id: GO:0045186 name: zonula adherens assembly namespace: biological_process def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] is_a: GO:0034333 ! adherens junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0045187 name: regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] synonym: "regulation of sleep" EXACT [] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045188 name: regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators] synonym: "regulation of non-REM sleep" EXACT [] is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0045189 name: connective tissue growth factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de] synonym: "connective tissue growth factor anabolism" EXACT [] synonym: "connective tissue growth factor biosynthesis" EXACT [] synonym: "connective tissue growth factor formation" EXACT [] synonym: "connective tissue growth factor synthesis" EXACT [] synonym: "CTGF biosynthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032601 ! connective tissue growth factor production [Term] id: GO:0045190 name: isotype switching namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149] comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'. synonym: "class switch recombination" EXACT [] synonym: "class switching" EXACT [] synonym: "isotype switch recombination" EXACT [] xref: Wikipedia:Immunoglobulin_class_switching is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response is_a: GO:0002312 ! B cell activation involved in immune response [Term] id: GO:0045191 name: regulation of isotype switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai] synonym: "regulation of class switch recombination" EXACT [] synonym: "regulation of class switching" EXACT [] synonym: "regulation of isotype switch recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0050864 ! regulation of B cell activation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045190 ! isotype switching relationship: regulates GO:0045190 ! isotype switching [Term] id: GO:0045192 name: obsolete low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "LDL catabolic process" EXACT [] synonym: "LDL catabolism" EXACT [] synonym: "low-density lipoprotein breakdown" EXACT [] synonym: "low-density lipoprotein catabolic process" EXACT [] synonym: "low-density lipoprotein catabolism" EXACT [] synonym: "low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045193 name: obsolete acetylated low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "Ac-LDL catabolic process" EXACT [] synonym: "Ac-LDL catabolism" EXACT [] synonym: "acetylated low-density lipoprotein breakdown" EXACT [] synonym: "acetylated low-density lipoprotein catabolic process" EXACT [] synonym: "acetylated low-density lipoprotein catabolism" EXACT [] synonym: "acetylated low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045194 name: obsolete oxidized low-density lipoprotein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators] comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. synonym: "Ox-LDL catabolic process" EXACT [] synonym: "Ox-LDL catabolism" EXACT [] synonym: "oxidized low-density lipoprotein breakdown" EXACT [] synonym: "oxidized low-density lipoprotein catabolic process" EXACT [] synonym: "oxidized low-density lipoprotein catabolism" EXACT [] synonym: "oxidized low-density lipoprotein degradation" EXACT [] is_obsolete: true [Term] id: GO:0045195 name: obsolete gallstone formation namespace: biological_process def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm] comment: This term was made obsolete because the process it represents is pathological. synonym: "gallstone formation" EXACT [] is_obsolete: true [Term] id: GO:0045196 name: establishment or maintenance of neuroblast polarity namespace: biological_process alt_id: GO:0043339 alt_id: GO:0043342 def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0055059 ! asymmetric neuroblast division [Term] id: GO:0045197 name: establishment or maintenance of epithelial cell apical/basal polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity [Term] id: GO:0045198 name: establishment of epithelial cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0030859 ! polarized epithelial cell differentiation is_a: GO:0035089 ! establishment of apical/basal cell polarity is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity is_a: GO:0090162 ! establishment of epithelial cell polarity [Term] id: GO:0045199 name: maintenance of epithelial cell apical/basal polarity namespace: biological_process def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf] is_a: GO:0035090 ! maintenance of apical/basal cell polarity is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity [Term] id: GO:0045200 name: establishment of neuroblast polarity namespace: biological_process alt_id: GO:0043340 alt_id: GO:0043343 def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "establishment of neuroblast cell polarity" EXACT [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity [Term] id: GO:0045201 name: maintenance of neuroblast polarity namespace: biological_process alt_id: GO:0043341 alt_id: GO:0043344 def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0030011 ! maintenance of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_synapse synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0045203 name: integral component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators, GOC:mtg_sensu] synonym: "integral to cell outer membrane" NARROW [] synonym: "integral to external membrane" RELATED [] synonym: "integral to outer membrane" RELATED [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031230 ! intrinsic component of cell outer membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0045204 name: MAPK export from nucleus namespace: biological_process def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "cytoplasmic translocation of MAP kinase" EXACT [] synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT [] synonym: "MAPK export from cell nucleus" EXACT [] synonym: "MAPK export out of nucleus" EXACT [] synonym: "MAPK transport from nucleus to cytoplasm" EXACT [] synonym: "MAPK-nucleus export" EXACT [] is_a: GO:0006611 ! protein export from nucleus [Term] id: GO:0045205 name: obsolete MAPK transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because we do not know what it was intended to represent when it was created. synonym: "MAPK transporter activity" EXACT [] is_obsolete: true [Term] id: GO:0045206 name: obsolete MAPK phosphatase transporter activity namespace: molecular_function alt_id: GO:0045207 def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because we do not know what it was intended to represent when it was created. synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW [] synonym: "leptomycin B-sensitive MKP shuttle" NARROW [] synonym: "MAPK phosphatase transporter activity" EXACT [] synonym: "MKP shuttle" NARROW [] is_obsolete: true [Term] id: GO:0045208 name: MAPK phosphatase export from nucleus namespace: biological_process def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "MAPK phosphatase export from cell nucleus" EXACT [] synonym: "MAPK phosphatase export out of nucleus" EXACT [] synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] synonym: "MAPK phosphatase-nucleus export" EXACT [] is_a: GO:0006611 ! protein export from nucleus [Term] id: GO:0045209 name: MAPK phosphatase export from nucleus, leptomycin B sensitive namespace: biological_process def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT [] synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT [] synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT [] synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT [] is_a: GO:0045208 ! MAPK phosphatase export from nucleus [Term] id: GO:0045210 name: FasL biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/] synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add] synonym: "CD178 biosynthetic process" EXACT [GOC:add] synonym: "CD95L biosynthesis" EXACT [GOC:add] synonym: "CD95L biosynthetic process" EXACT [GOC:add] synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095] synonym: "Fas-L biosynthetic process" EXACT [GOC:add] synonym: "FasL anabolism" EXACT [] synonym: "FasL biosynthesis" EXACT [] synonym: "FasL formation" EXACT [] synonym: "FasL synthesis" EXACT [] synonym: "FASLG biosynthetic process" EXACT [GOC:add] is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0045211 name: postsynaptic membrane namespace: cellular_component def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] subset: goslim_synapse synonym: "post-synaptic membrane" EXACT [] is_a: GO:0097060 ! synaptic membrane relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0045212 name: neurotransmitter receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai] synonym: "neurotransmitter receptor anabolism" EXACT [] synonym: "neurotransmitter receptor biosynthesis" EXACT [] synonym: "neurotransmitter receptor formation" EXACT [] synonym: "neurotransmitter receptor synthesis" EXACT [] is_a: GO:0032800 ! receptor biosynthetic process is_a: GO:0045213 ! neurotransmitter receptor metabolic process [Term] id: GO:0045213 name: neurotransmitter receptor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators] synonym: "neurotransmitter receptor metabolism" EXACT [] is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process alt_id: GO:0006938 def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [] is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0045216 name: cell-cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "cell-cell junction assembly and maintenance" EXACT [] synonym: "cell-cell junction biogenesis" RELATED [] synonym: "cell-cell junction organisation" EXACT [GOC:mah] synonym: "intercellular junction assembly and maintenance" EXACT [] is_a: GO:0034330 ! cell junction organization [Term] id: GO:0045217 name: cell-cell junction maintenance namespace: biological_process def: "The maintenance of junctions between cells." [GOC:ai] synonym: "intercellular junction maintenance" EXACT [] is_a: GO:0034331 ! cell junction maintenance is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0045218 name: zonula adherens maintenance namespace: biological_process def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf] is_a: GO:0034334 ! adherens junction maintenance [Term] id: GO:0045219 name: regulation of FasL biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "regulation of FasL anabolism" EXACT [] synonym: "regulation of FasL biosynthesis" EXACT [] synonym: "regulation of FasL formation" EXACT [] synonym: "regulation of FasL synthesis" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045210 ! FasL biosynthetic process relationship: regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045220 name: positive regulation of FasL biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "activation of FasL biosynthetic process" NARROW [] synonym: "positive regulation of FasL anabolism" EXACT [] synonym: "positive regulation of FasL biosynthesis" EXACT [] synonym: "positive regulation of FasL formation" EXACT [] synonym: "positive regulation of FasL synthesis" EXACT [] synonym: "stimulation of FasL biosynthetic process" NARROW [] synonym: "up regulation of FasL biosynthetic process" EXACT [] synonym: "up-regulation of FasL biosynthetic process" EXACT [] synonym: "upregulation of FasL biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0045219 ! regulation of FasL biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045210 ! FasL biosynthetic process relationship: positively_regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045221 name: negative regulation of FasL biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "down regulation of FasL biosynthetic process" EXACT [] synonym: "down-regulation of FasL biosynthetic process" EXACT [] synonym: "downregulation of FasL biosynthetic process" EXACT [] synonym: "inhibition of FasL biosynthetic process" NARROW [] synonym: "negative regulation of FasL anabolism" EXACT [] synonym: "negative regulation of FasL biosynthesis" EXACT [] synonym: "negative regulation of FasL formation" EXACT [] synonym: "negative regulation of FasL synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0045219 ! regulation of FasL biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045210 ! FasL biosynthetic process relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045222 name: CD4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732] synonym: "CD4 anabolism" EXACT [] synonym: "CD4 biosynthesis" EXACT [] synonym: "CD4 formation" EXACT [] synonym: "CD4 synthesis" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0045223 name: regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "regulation of CD4 anabolism" EXACT [] synonym: "regulation of CD4 biosynthesis" EXACT [] synonym: "regulation of CD4 formation" EXACT [] synonym: "regulation of CD4 synthesis" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045222 ! CD4 biosynthetic process relationship: regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045224 name: positive regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "activation of CD4 biosynthetic process" NARROW [] synonym: "positive regulation of CD4 anabolism" EXACT [] synonym: "positive regulation of CD4 biosynthesis" EXACT [] synonym: "positive regulation of CD4 formation" EXACT [] synonym: "positive regulation of CD4 synthesis" EXACT [] synonym: "stimulation of CD4 biosynthetic process" NARROW [] synonym: "up regulation of CD4 biosynthetic process" EXACT [] synonym: "up-regulation of CD4 biosynthetic process" EXACT [] synonym: "upregulation of CD4 biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0045223 ! regulation of CD4 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045222 ! CD4 biosynthetic process relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045225 name: negative regulation of CD4 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "down regulation of CD4 biosynthetic process" EXACT [] synonym: "down-regulation of CD4 biosynthetic process" EXACT [] synonym: "downregulation of CD4 biosynthetic process" EXACT [] synonym: "inhibition of CD4 biosynthetic process" NARROW [] synonym: "negative regulation of CD4 anabolism" EXACT [] synonym: "negative regulation of CD4 biosynthesis" EXACT [] synonym: "negative regulation of CD4 formation" EXACT [] synonym: "negative regulation of CD4 synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0045223 ! regulation of CD4 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045222 ! CD4 biosynthetic process relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045226 name: extracellular polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] synonym: "extracellular polysaccharide anabolism" EXACT [] synonym: "extracellular polysaccharide biosynthesis" EXACT [] synonym: "extracellular polysaccharide formation" EXACT [] synonym: "extracellular polysaccharide synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046379 ! extracellular polysaccharide metabolic process [Term] id: GO:0045227 name: capsule polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators] synonym: "capsular polysaccharide biosynthesis" EXACT [] synonym: "capsular polysaccharide biosynthetic process" EXACT [] synonym: "capsule polysaccharide anabolism" EXACT [] synonym: "capsule polysaccharide biosynthesis" EXACT [] synonym: "capsule polysaccharide formation" EXACT [] synonym: "capsule polysaccharide synthesis" EXACT [] is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process is_a: GO:0045230 ! capsule organization [Term] id: GO:0045228 name: slime layer polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators] synonym: "slime layer polysaccharide anabolism" EXACT [] synonym: "slime layer polysaccharide biosynthesis" EXACT [] synonym: "slime layer polysaccharide formation" EXACT [] synonym: "slime layer polysaccharide synthesis" EXACT [] is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process is_a: GO:0045231 ! slime layer organization [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "external encapsulating structure organisation" EXACT [] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0045230 name: capsule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] subset: goslim_pir synonym: "capsule organisation" EXACT [] synonym: "capsule organization and biogenesis" RELATED [] xref: MIPS_funcat:42.34.03 is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045231 name: slime layer organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai] subset: goslim_pir synonym: "slime layer organisation" EXACT [] synonym: "slime layer organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.34.03 is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045232 name: S-layer organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai] synonym: "S-layer organisation" EXACT [] synonym: "S-layer organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.34.05 is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0045233 name: obsolete natural killer cell receptor activity namespace: molecular_function def: "OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc] comment: This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity. synonym: "Ly49i" NARROW [] synonym: "natural killer cell receptor activity" EXACT [] synonym: "NK cell receptor activity" EXACT [] is_obsolete: true consider: GO:0002769 consider: GO:0004888 consider: GO:0030101 [Term] id: GO:0045234 name: protein palmitoleylation namespace: biological_process alt_id: GO:0045235 def: "The covalent attachment of a palmitoleyl group to a protein." [GOC:ai] synonym: "protein amino acid palmitoleylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0045236 name: CXCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] synonym: "alpha chemokine receptor binding" EXACT [] synonym: "alpha chemokine receptor ligand" NARROW [] synonym: "C-X-C chemokine receptor ligand" NARROW [] synonym: "CXC chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0045237 name: CXCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR1 chemokine receptor ligand" NARROW [] is_a: GO:0005153 ! interleukin-8 receptor binding [Term] id: GO:0045238 name: CXCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892] synonym: "CXCR2 chemokine receptor ligand" NARROW [] is_a: GO:0005153 ! interleukin-8 receptor binding [Term] id: GO:0045239 name: tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah] subset: goslim_pir synonym: "TCA cycle enzyme complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045240 name: dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah] synonym: "2-oxoglutarate dehydrogenase complex" EXACT [] synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT [] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0045241 name: cytosolic alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex [Term] id: GO:0045242 name: isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0045243 name: cytosolic isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD [] is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex intersection_of: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) intersection_of: part_of GO:0005829 ! cytosol [Term] id: GO:0045244 name: succinate-CoA ligase complex (GDP-forming) namespace: cellular_component alt_id: GO:0008325 alt_id: GO:0045245 def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl] synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0045246 name: cytosolic tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] synonym: "TCA cycle enzyme complex" BROAD [] synonym: "tricarboxylic acid cycle enzyme complex" BROAD [] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0045247 name: cytosolic electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732] is_a: GO:0045251 ! electron transfer flavoprotein complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0045248 name: cytosolic oxoglutarate dehydrogenase complex namespace: cellular_component def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. is_a: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0045249 name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex intersection_of: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0045250 name: cytosolic pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED [] is_a: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0045251 name: electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system." [GOC:bhm, ISBN:0198506732] subset: goslim_pir synonym: "ETF complex" EXACT [GOC:bhm] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045252 name: oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. subset: goslim_pir synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex is_a: GO:1990234 ! transferase complex [Term] id: GO:0045253 name: pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502] comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. subset: goslim_pir is_a: GO:1903293 ! phosphatase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045254 name: pyruvate dehydrogenase complex namespace: cellular_component alt_id: GO:0009364 def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. subset: goslim_pir synonym: "dihydrolipoyl dehydrogenase complex" BROAD [] synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT [] xref: MIPS_funcat:02.08 xref: Wikipedia:Pyruvate_dehydrogenase_complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0045257 name: succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684] is_a: GO:0045281 ! succinate dehydrogenase complex [Term] id: GO:0045258 name: plasma membrane succinate dehydrogenase complex (ubiquinone) namespace: cellular_component def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex intersection_of: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0045259 name: proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0045255 def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] synonym: "F1-F0 complex" EXACT [] synonym: "hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "hydrogen-transporting ATP synthase complex" EXACT [] synonym: "proton-transporting F-type ATPase complex" RELATED [] is_a: GO:0016469 ! proton-transporting two-sector ATPase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0045260 name: plasma membrane proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0045256 def: "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684] synonym: "hydrogen-translocating F-type ATPase complex" BROAD [] synonym: "hydrogen-transporting ATP synthase" EXACT [] synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "proton-transporting ATP synthase complex" BROAD [] is_a: GO:0045259 ! proton-transporting ATP synthase complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045259 ! proton-transporting ATP synthase complex intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0045261 name: proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT [] is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex [Term] id: GO:0045262 name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'plasma membrane ; GO:0005886'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex [Term] id: GO:0045263 name: proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah] synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW [] synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT [] is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex [Term] id: GO:0045264 name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD [] synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD [] is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex [Term] id: GO:0045265 name: proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056] synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0045266 name: plasma membrane proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD [] synonym: "proton-transporting ATP synthase, stator stalk" BROAD [] is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0045267 name: proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056] synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045268 name: plasma membrane proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD [] synonym: "proton-transporting ATP synthase, catalytic core" BROAD [] is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045267 ! proton-transporting ATP synthase, catalytic core intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045269 name: proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056] synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045270 name: plasma membrane proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD [] synonym: "proton-transporting ATP synthase, central stalk" BROAD [] is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045269 ! proton-transporting ATP synthase, central stalk intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0045271 name: respiratory chain complex I namespace: cellular_component alt_id: GO:0045279 def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. synonym: "electron transport complex I" RELATED [] synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT [] synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT [] synonym: "NADH-Q oxidoreductase complex" EXACT [] is_a: GO:0030964 ! NADH dehydrogenase complex is_a: GO:0098803 ! respiratory chain complex [Term] id: GO:0045272 name: plasma membrane respiratory chain complex I namespace: cellular_component def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD [] synonym: "respiratory chain complex I" BROAD [] is_a: GO:0045271 ! respiratory chain complex I is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045271 ! respiratory chain complex I intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0070470 ! plasma membrane respirasome [Term] id: GO:0045273 name: respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684] subset: goslim_pir synonym: "electron transport complex II" RELATED [] is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0045274 name: plasma membrane respiratory chain complex II namespace: cellular_component def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] synonym: "respiratory chain complex II" BROAD [] is_a: GO:0045273 ! respiratory chain complex II is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045273 ! respiratory chain complex II intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0070470 ! plasma membrane respirasome [Term] id: GO:0045275 name: respiratory chain complex III namespace: cellular_component alt_id: GO:0032842 alt_id: GO:0045285 def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733] subset: goslim_pir synonym: "coenzyme Q-cytochrome c oxidoreductase complex" RELATED [] synonym: "coenzyme Q-cytochrome c reductase complex" RELATED [] synonym: "complex III" EXACT [] synonym: "CoQH2-cytochrome c reductase complex" RELATED [] synonym: "cytochrome bc(1) complex" EXACT [] synonym: "cytochrome bc1 complex" EXACT [] synonym: "electron transport complex III" RELATED [] synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT [] synonym: "ubiquinol-cytochrome-c reductase complex" EXACT [] xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase is_a: GO:0070069 ! cytochrome complex is_a: GO:0098803 ! respiratory chain complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0045276 name: plasma membrane respiratory chain complex III namespace: cellular_component alt_id: GO:0045286 def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] synonym: "plasma membrane coenzyme Q-cytochrome c oxidoreductase complex" EXACT [] synonym: "plasma membrane coenzyme Q-cytochrome c reductase complex" EXACT [] synonym: "plasma membrane cytochrome bc1 complex" EXACT [] synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT [] synonym: "respiratory chain complex III" BROAD [] synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD [] synonym: "ubiquinol-cytochrome-c reductase complex" BROAD [] is_a: GO:0045275 ! respiratory chain complex III is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045275 ! respiratory chain complex III intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0070470 ! plasma membrane respirasome [Term] id: GO:0045277 name: respiratory chain complex IV namespace: cellular_component alt_id: GO:0045287 def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] subset: goslim_pir synonym: "cytochrome c oxidase complex" EXACT [] synonym: "electron transport complex IV" RELATED [] is_a: GO:0070069 ! cytochrome complex is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0045278 name: plasma membrane respiratory chain complex IV namespace: cellular_component alt_id: GO:0045288 def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] synonym: "cytochrome c oxidase complex" BROAD [] synonym: "respiratory chain complex IV" BROAD [] is_a: GO:0045277 ! respiratory chain complex IV is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045277 ! respiratory chain complex IV intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0070470 ! plasma membrane respirasome [Term] id: GO:0045281 name: succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701] is_a: GO:0098803 ! respiratory chain complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0045273 ! respiratory chain complex II [Term] id: GO:0045282 name: plasma membrane succinate dehydrogenase complex namespace: cellular_component def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701] synonym: "succinate dehydrogenase complex" BROAD [] is_a: GO:0045281 ! succinate dehydrogenase complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045281 ! succinate dehydrogenase complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II [Term] id: GO:0045283 name: fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0045273 ! respiratory chain complex II [Term] id: GO:0045284 name: plasma membrane fumarate reductase complex namespace: cellular_component def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224] comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. synonym: "fumarate reductase complex" BROAD [] is_a: GO:0045283 ! fumarate reductase complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0045283 ! fumarate reductase complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II [Term] id: GO:0045289 name: luciferin monooxygenase activity namespace: molecular_function def: "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf] synonym: "luciferase activity" EXACT [] synonym: "luciferase monooxygenase activity" RELATED [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0045290 name: D-arabinose 1-dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117] synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117] xref: EC:1.1.1.117 xref: MetaCyc:1.1.1.117-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045291 name: mRNA trans splicing, SL addition namespace: biological_process def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423] synonym: "nuclear mRNA trans splicing, SL addition" EXACT [GOC:vw] synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT [] is_a: GO:0000365 ! mRNA trans splicing, via spliceosome [Term] id: GO:0045292 name: mRNA cis splicing, via spliceosome namespace: biological_process def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897] synonym: "nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:vw] synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [] synonym: "splicing" BROAD [GOC:vw] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0045293 name: mRNA editing complex namespace: cellular_component def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607, PMID:24316715] subset: goslim_pir synonym: "editosome" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0045294 name: alpha-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045295 name: gamma-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gamma subunit of the catenin complex." [GOC:bf] synonym: "plakoglobin binding" EXACT [GOC:BHF] is_a: GO:0005515 ! protein binding [Term] id: GO:0045296 name: cadherin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] is_a: GO:0050839 ! cell adhesion molecule binding [Term] id: GO:0045297 name: post-mating behavior namespace: biological_process def: "The specific behavior of an organism following mating." [GOC:bf, GOC:pr] synonym: "post-mating behaviour" EXACT [] is_a: GO:0019098 ! reproductive behavior [Term] id: GO:0045298 name: tubulin complex namespace: cellular_component def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0045299 name: otolith mineralization namespace: biological_process def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0048840 ! otolith development [Term] id: GO:0045300 name: acyl-[acyl-carrier-protein] desaturase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2] comment: Note that this function was formerly EC:1.14.99.6. synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT [] synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2] synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2] synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2] xref: EC:1.14.19.2 xref: MetaCyc:1.14.19.2-RXN xref: MetaCyc:PWY-5147 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0045301 name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666] synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT [] synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT [] synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0002195 ! 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis [Term] id: GO:0045302 name: choloylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24] synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24] synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24] synonym: "glycocholase activity" EXACT [EC:3.5.1.24] xref: EC:3.5.1.24 xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN xref: RHEA:19353 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0045303 name: diaminobutyrate-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11160] synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76] synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "EctB" RELATED [EC:2.6.1.76] synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] xref: EC:2.6.1.76 xref: KEGG_REACTION:R06977 xref: MetaCyc:R101-RXN xref: RHEA:11160 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0045304 name: regulation of establishment of competence for transformation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg] synonym: "regulator of establishment of competence for transformation activity" RELATED [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032104 ! regulation of response to extracellular stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030420 ! establishment of competence for transformation relationship: regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045305 name: obsolete regulator of establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. synonym: "regulator of establishment of competence for transformation activity" EXACT [] is_obsolete: true replaced_by: GO:0045304 [Term] id: GO:0045306 name: obsolete inhibitor of the establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. synonym: "inhibitor of the establishment of competence for transformation activity" EXACT [] is_obsolete: true replaced_by: GO:0045808 [Term] id: GO:0045307 name: obsolete activator of the establishment of competence for transformation activity namespace: molecular_function def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg] comment: This term was made obsolete because it does not represent a true function. synonym: "activator of the establishment of competence for transformation activity" EXACT [] is_obsolete: true replaced_by: GO:0045809 [Term] id: GO:0045309 name: protein phosphorylated amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein." [GOC:go_curators] synonym: "phosphoprotein amino acid binding" RELATED [] is_a: GO:0051219 ! phosphoprotein binding [Term] id: GO:0045310 name: obsolete phosphoserine/phosphothreonine binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators] comment: This term was made obsolete because it represents two functions. synonym: "phosphoserine/phosphothreonine binding" EXACT [] is_obsolete: true consider: GO:0050815 consider: GO:0050816 [Term] id: GO:0045311 name: invasive growth in response to pheromone namespace: biological_process def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc] is_a: GO:0036267 ! invasive filamentous growth relationship: part_of GO:0019236 ! response to pheromone [Term] id: GO:0045312 name: nor-spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators] synonym: "nor-spermidine anabolism" EXACT [] synonym: "nor-spermidine biosynthesis" EXACT [] synonym: "nor-spermidine formation" EXACT [] synonym: "nor-spermidine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0046204 ! nor-spermidine metabolic process [Term] id: GO:0045313 name: rhabdomere membrane biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0042052 ! rhabdomere development [Term] id: GO:0045314 name: regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "regulation of eye photoreceptor development" BROAD [] is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation relationship: regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045315 name: positive regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "activation of eye photoreceptor development" BROAD [] synonym: "positive regulation of eye photoreceptor development" BROAD [] synonym: "stimulation of eye photoreceptor development" BROAD [] synonym: "up regulation of eye photoreceptor development" BROAD [] synonym: "up-regulation of eye photoreceptor development" BROAD [] synonym: "upregulation of eye photoreceptor development" BROAD [] is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042051 ! compound eye photoreceptor development relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045316 name: negative regulation of compound eye photoreceptor development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] synonym: "down regulation of eye photoreceptor development" BROAD [] synonym: "down-regulation of eye photoreceptor development" BROAD [] synonym: "downregulation of eye photoreceptor development" BROAD [] synonym: "inhibition of eye photoreceptor development" BROAD [] synonym: "negative regulation of eye photoreceptor development" BROAD [] is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development is_a: GO:0045314 ! regulation of compound eye photoreceptor development is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042051 ! compound eye photoreceptor development relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045317 name: equator specification namespace: biological_process def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity [Term] id: GO:0045319 name: obsolete SRP-independent cotranslational protein-membrane targeting, translocation namespace: biological_process def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT [] synonym: "SRP-independent cotranslational protein-membrane targeting, translocation" EXACT [] is_obsolete: true [Term] id: GO:0045320 name: chloroplast proton-transporting ATP synthase complex namespace: cellular_component def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663] synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT [] synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT [] synonym: "hydrogen-translocating F-type ATPase complex" BROAD [] is_a: GO:0045259 ! proton-transporting ATP synthase complex is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex intersection_of: GO:0045259 ! proton-transporting ATP synthase complex intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0045321 name: leukocyte activation namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] synonym: "immune cell activation" EXACT [] synonym: "leucocyte activation" EXACT [] xref: Wikipedia:Immunologic_activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process [Term] id: GO:0045322 name: unmethylated CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0045323 name: interleukin-1 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075] synonym: "IL-1 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0045324 name: late endosome to vacuole transport namespace: biological_process def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0045325 name: peptidyl-tryptophan hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322] xref: RESID:AA0322 is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0045326 name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323] synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah] xref: RESID:AA0323 is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine [Term] id: GO:0045327 name: protein-DNA covalent cross-linking via peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg] synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah] is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0045328 name: cytochrome P450 4A1-heme linkage namespace: biological_process def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [GOC:cjm, RESID:AA0324] synonym: "cytochrome P450 4A1-haem linkage" EXACT [] xref: RESID:AA0324 is_a: GO:0017003 ! protein-heme linkage relationship: part_of GO:0017004 ! cytochrome complex assembly [Term] id: GO:0045329 name: carnitine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] synonym: "carnitine anabolism" EXACT [] synonym: "carnitine biosynthesis" EXACT [] synonym: "carnitine formation" EXACT [] synonym: "carnitine synthesis" EXACT [] synonym: "vitamin Bt biosynthesis" EXACT [] synonym: "vitamin Bt biosynthetic process" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0045330 name: aspartyl esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB-KW:KW-0063] is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0045331 name: obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2] comment: This term was made obsolete because it represents two activities. synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" EXACT [] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT [] synonym: "heterodisulfide reductase activity" EXACT [] is_obsolete: true consider: GO:0051911 consider: GO:0051912 [Term] id: GO:0045332 name: phospholipid translocation namespace: biological_process def: "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864] comment: Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'. synonym: "flippase" RELATED [] synonym: "phospholipid scrambling" RELATED [] is_a: GO:0015914 ! phospholipid transport is_a: GO:0034204 ! lipid translocation [Term] id: GO:0045333 name: cellular respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "oxidative metabolic process" EXACT [] synonym: "oxidative metabolism" EXACT [] synonym: "respiration" BROAD [] xref: MIPS_funcat:02.13 xref: Wikipedia:Cellular_respiration is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0045334 name: clathrin-coated endocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] xref: NIF_Subcellular:sao1243595998 is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0045335 name: phagocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732] synonym: "phagosome" EXACT [] xref: Wikipedia:Phagosome is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0045336 name: clathrin-coated phagocytic vesicle namespace: cellular_component def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732] synonym: "clathrin-coated phagosome" EXACT [] is_a: GO:0045334 ! clathrin-coated endocytic vesicle is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0045337 name: farnesyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl] synonym: "farnesyl diphosphate anabolism" EXACT [] synonym: "farnesyl diphosphate biosynthesis" EXACT [] synonym: "farnesyl diphosphate formation" EXACT [] synonym: "farnesyl diphosphate synthesis" EXACT [] xref: MetaCyc:PWY-5123 is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0045338 ! farnesyl diphosphate metabolic process [Term] id: GO:0045338 name: farnesyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators] synonym: "farnesyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0045339 name: farnesyl diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators] synonym: "farnesyl diphosphate breakdown" EXACT [] synonym: "farnesyl diphosphate catabolism" EXACT [] synonym: "farnesyl diphosphate degradation" EXACT [] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0016115 ! terpenoid catabolic process is_a: GO:0045338 ! farnesyl diphosphate metabolic process [Term] id: GO:0045340 name: mercury ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with mercury (Hg) ions." [GOC:go_curators] synonym: "mercury binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0045341 name: MHC class I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators] synonym: "major histocompatibility complex class I biosynthesis" EXACT [] synonym: "major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "MHC class I anabolism" EXACT [] synonym: "MHC class I biosynthesis" EXACT [] synonym: "MHC class I formation" EXACT [] synonym: "MHC class I synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0045342 name: MHC class II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators] synonym: "major histocompatibility complex class II biosynthesis" EXACT [] synonym: "major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "MHC class II anabolism" EXACT [] synonym: "MHC class II biosynthesis" EXACT [] synonym: "MHC class II formation" EXACT [] synonym: "MHC class II synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0045343 name: regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "regulation of MHC class I anabolism" EXACT [] synonym: "regulation of MHC class I biosynthesis" EXACT [] synonym: "regulation of MHC class I formation" EXACT [] synonym: "regulation of MHC class I synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045341 ! MHC class I biosynthetic process relationship: regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045344 name: negative regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "down regulation of MHC class I biosynthetic process" EXACT [] synonym: "down-regulation of MHC class I biosynthetic process" EXACT [] synonym: "downregulation of MHC class I biosynthetic process" EXACT [] synonym: "inhibition of MHC class I biosynthetic process" NARROW [] synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "negative regulation of MHC class I anabolism" EXACT [] synonym: "negative regulation of MHC class I biosynthesis" EXACT [] synonym: "negative regulation of MHC class I formation" EXACT [] synonym: "negative regulation of MHC class I synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045343 ! regulation of MHC class I biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045341 ! MHC class I biosynthetic process relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045345 name: positive regulation of MHC class I biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] synonym: "activation of MHC class I biosynthetic process" NARROW [] synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT [] synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT [] synonym: "positive regulation of MHC class I anabolism" EXACT [] synonym: "positive regulation of MHC class I biosynthesis" EXACT [] synonym: "positive regulation of MHC class I formation" EXACT [] synonym: "positive regulation of MHC class I synthesis" EXACT [] synonym: "stimulation of MHC class I biosynthetic process" NARROW [] synonym: "up regulation of MHC class I biosynthetic process" EXACT [] synonym: "up-regulation of MHC class I biosynthetic process" EXACT [] synonym: "upregulation of MHC class I biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045343 ! regulation of MHC class I biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045341 ! MHC class I biosynthetic process relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process [Term] id: GO:0045346 name: regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "regulation of MHC class II anabolism" EXACT [] synonym: "regulation of MHC class II biosynthesis" EXACT [] synonym: "regulation of MHC class II formation" EXACT [] synonym: "regulation of MHC class II synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045342 ! MHC class II biosynthetic process relationship: regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045347 name: negative regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "down regulation of MHC class II biosynthetic process" EXACT [] synonym: "down-regulation of MHC class II biosynthetic process" EXACT [] synonym: "downregulation of MHC class II biosynthetic process" EXACT [] synonym: "inhibition of MHC class II biosynthetic process" NARROW [] synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "negative regulation of MHC class II anabolism" EXACT [] synonym: "negative regulation of MHC class II biosynthesis" EXACT [] synonym: "negative regulation of MHC class II formation" EXACT [] synonym: "negative regulation of MHC class II synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045346 ! regulation of MHC class II biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045342 ! MHC class II biosynthetic process relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045348 name: positive regulation of MHC class II biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] synonym: "activation of MHC class II biosynthetic process" NARROW [] synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT [] synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT [] synonym: "positive regulation of MHC class II anabolism" EXACT [] synonym: "positive regulation of MHC class II biosynthesis" EXACT [] synonym: "positive regulation of MHC class II formation" EXACT [] synonym: "positive regulation of MHC class II synthesis" EXACT [] synonym: "stimulation of MHC class II biosynthetic process" NARROW [] synonym: "up regulation of MHC class II biosynthetic process" EXACT [] synonym: "up-regulation of MHC class II biosynthetic process" EXACT [] synonym: "upregulation of MHC class II biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045346 ! regulation of MHC class II biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045342 ! MHC class II biosynthetic process relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process [Term] id: GO:0045349 name: interferon-alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "IFN-alpha biosynthesis" EXACT [] synonym: "IFN-alpha biosynthetic process" EXACT [] synonym: "interferon-alpha anabolism" EXACT [] synonym: "interferon-alpha biosynthesis" EXACT [] synonym: "interferon-alpha formation" EXACT [] synonym: "interferon-alpha synthesis" EXACT [] is_a: GO:0045351 ! type I interferon biosynthetic process relationship: part_of GO:0032607 ! interferon-alpha production [Term] id: GO:0045350 name: interferon-beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "IFN-beta biosynthesis" EXACT [] synonym: "IFN-beta biosynthetic process" EXACT [] synonym: "IFNB biosynthetic process" EXACT [GOC:mah] synonym: "interferon-beta anabolism" EXACT [] synonym: "interferon-beta biosynthesis" EXACT [] synonym: "interferon-beta formation" EXACT [] synonym: "interferon-beta synthesis" EXACT [] is_a: GO:0045351 ! type I interferon biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032608 ! interferon-beta production [Term] id: GO:0045351 name: type I interferon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add] synonym: "interferon type I biosynthetic process" EXACT [] synonym: "type I interferon anabolism" EXACT [] synonym: "type I interferon biosynthesis" EXACT [] synonym: "type I interferon formation" EXACT [] synonym: "type I interferon synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032606 ! type I interferon production [Term] id: GO:0045352 name: interleukin-1 type I receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 type I receptors." [GOC:ebc] synonym: "IL-1ra type I" EXACT [] is_a: GO:0005152 ! interleukin-1 receptor antagonist activity [Term] id: GO:0045353 name: interleukin-1 type II receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to interleukin-1 type II receptors." [GOC:ebc] synonym: "IL-1ra type II" EXACT [] is_a: GO:0005152 ! interleukin-1 receptor antagonist activity [Term] id: GO:0045354 name: regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "regulation of interferon-alpha anabolism" EXACT [] synonym: "regulation of interferon-alpha biosynthesis" EXACT [] synonym: "regulation of interferon-alpha formation" EXACT [] synonym: "regulation of interferon-alpha synthesis" EXACT [] is_a: GO:0032647 ! regulation of interferon-alpha production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045349 ! interferon-alpha biosynthetic process relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045355 name: negative regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "down regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "downregulation of interferon-alpha biosynthetic process" EXACT [] synonym: "inhibition of interferon-alpha biosynthetic process" NARROW [] synonym: "negative regulation of interferon-alpha anabolism" EXACT [] synonym: "negative regulation of interferon-alpha biosynthesis" EXACT [] synonym: "negative regulation of interferon-alpha formation" EXACT [] synonym: "negative regulation of interferon-alpha synthesis" EXACT [] is_a: GO:0032687 ! negative regulation of interferon-alpha production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045356 name: positive regulation of interferon-alpha biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] synonym: "activation of interferon-alpha biosynthetic process" NARROW [] synonym: "positive regulation of interferon-alpha anabolism" EXACT [] synonym: "positive regulation of interferon-alpha biosynthesis" EXACT [] synonym: "positive regulation of interferon-alpha formation" EXACT [] synonym: "positive regulation of interferon-alpha synthesis" EXACT [] synonym: "stimulation of interferon-alpha biosynthetic process" NARROW [] synonym: "up regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT [] synonym: "upregulation of interferon-alpha biosynthetic process" EXACT [] is_a: GO:0032727 ! positive regulation of interferon-alpha production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process [Term] id: GO:0045357 name: regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "regulation of interferon-beta anabolism" EXACT [] synonym: "regulation of interferon-beta biosynthesis" EXACT [] synonym: "regulation of interferon-beta formation" EXACT [] synonym: "regulation of interferon-beta synthesis" EXACT [] is_a: GO:0032648 ! regulation of interferon-beta production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045350 ! interferon-beta biosynthetic process relationship: regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045358 name: negative regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "down regulation of interferon-beta biosynthetic process" EXACT [] synonym: "down-regulation of interferon-beta biosynthetic process" EXACT [] synonym: "downregulation of interferon-beta biosynthetic process" EXACT [] synonym: "inhibition of interferon-beta biosynthetic process" NARROW [] synonym: "negative regulation of interferon-beta anabolism" EXACT [] synonym: "negative regulation of interferon-beta biosynthesis" EXACT [] synonym: "negative regulation of interferon-beta formation" EXACT [] synonym: "negative regulation of interferon-beta synthesis" EXACT [] is_a: GO:0032688 ! negative regulation of interferon-beta production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045359 name: positive regulation of interferon-beta biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] synonym: "activation of interferon-beta biosynthetic process" NARROW [] synonym: "positive regulation of interferon-beta anabolism" EXACT [] synonym: "positive regulation of interferon-beta biosynthesis" EXACT [] synonym: "positive regulation of interferon-beta formation" EXACT [] synonym: "positive regulation of interferon-beta synthesis" EXACT [] synonym: "stimulation of interferon-beta biosynthetic process" NARROW [] synonym: "up regulation of interferon-beta biosynthetic process" EXACT [] synonym: "up-regulation of interferon-beta biosynthetic process" EXACT [] synonym: "upregulation of interferon-beta biosynthetic process" EXACT [] is_a: GO:0032728 ! positive regulation of interferon-beta production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045350 ! interferon-beta biosynthetic process relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process [Term] id: GO:0045360 name: regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "regulation of IL-1 biosynthesis" EXACT [] synonym: "regulation of IL-1 biosynthetic process" EXACT [] synonym: "regulation of interleukin-1 anabolism" EXACT [] synonym: "regulation of interleukin-1 biosynthesis" EXACT [] synonym: "regulation of interleukin-1 formation" EXACT [] synonym: "regulation of interleukin-1 synthesis" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042222 ! interleukin-1 biosynthetic process relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045361 name: negative regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "down regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 biosynthetic process" NARROW [] synonym: "negative regulation of IL-1 biosynthesis" EXACT [] synonym: "negative regulation of IL-1 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-1 anabolism" EXACT [] synonym: "negative regulation of interleukin-1 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 formation" EXACT [] synonym: "negative regulation of interleukin-1 synthesis" EXACT [] is_a: GO:0032692 ! negative regulation of interleukin-1 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045362 name: positive regulation of interleukin-1 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] synonym: "activation of interleukin-1 biosynthetic process" NARROW [] synonym: "positive regulation of IL-1 biosynthesis" EXACT [] synonym: "positive regulation of IL-1 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-1 anabolism" EXACT [] synonym: "positive regulation of interleukin-1 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 formation" EXACT [] synonym: "positive regulation of interleukin-1 synthesis" EXACT [] synonym: "stimulation of interleukin-1 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 biosynthetic process" EXACT [] is_a: GO:0032732 ! positive regulation of interleukin-1 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process [Term] id: GO:0045363 name: regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "regulation of IL-11 biosynthesis" EXACT [] synonym: "regulation of IL-11 biosynthetic process" EXACT [] synonym: "regulation of interleukin-11 anabolism" EXACT [] synonym: "regulation of interleukin-11 biosynthesis" EXACT [] synonym: "regulation of interleukin-11 formation" EXACT [] synonym: "regulation of interleukin-11 synthesis" EXACT [] is_a: GO:0032654 ! regulation of interleukin-11 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042230 ! interleukin-11 biosynthetic process relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045364 name: negative regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "down regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-11 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-11 biosynthetic process" NARROW [] synonym: "negative regulation of IL-11 biosynthesis" EXACT [] synonym: "negative regulation of IL-11 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-11 anabolism" EXACT [] synonym: "negative regulation of interleukin-11 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-11 formation" EXACT [] synonym: "negative regulation of interleukin-11 synthesis" EXACT [] is_a: GO:0032694 ! negative regulation of interleukin-11 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045365 name: positive regulation of interleukin-11 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] synonym: "activation of interleukin-11 biosynthetic process" NARROW [] synonym: "positive regulation of IL-11 biosynthesis" EXACT [] synonym: "positive regulation of IL-11 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-11 anabolism" EXACT [] synonym: "positive regulation of interleukin-11 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-11 formation" EXACT [] synonym: "positive regulation of interleukin-11 synthesis" EXACT [] synonym: "stimulation of interleukin-11 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-11 biosynthetic process" EXACT [] is_a: GO:0032734 ! positive regulation of interleukin-11 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process [Term] id: GO:0045366 name: regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "regulation of IL-13 biosynthesis" EXACT [] synonym: "regulation of IL-13 biosynthetic process" EXACT [] synonym: "regulation of interleukin-13 anabolism" EXACT [] synonym: "regulation of interleukin-13 biosynthesis" EXACT [] synonym: "regulation of interleukin-13 formation" EXACT [] synonym: "regulation of interleukin-13 synthesis" EXACT [] is_a: GO:0032656 ! regulation of interleukin-13 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042231 ! interleukin-13 biosynthetic process relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045367 name: negative regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "down regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-13 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-13 biosynthetic process" NARROW [] synonym: "negative regulation of IL-13 biosynthesis" EXACT [] synonym: "negative regulation of IL-13 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-13 anabolism" EXACT [] synonym: "negative regulation of interleukin-13 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-13 formation" EXACT [] synonym: "negative regulation of interleukin-13 synthesis" EXACT [] is_a: GO:0032696 ! negative regulation of interleukin-13 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045368 name: positive regulation of interleukin-13 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] synonym: "activation of interleukin-13 biosynthetic process" NARROW [] synonym: "positive regulation of IL-13 biosynthesis" EXACT [] synonym: "positive regulation of IL-13 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-13 anabolism" EXACT [] synonym: "positive regulation of interleukin-13 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-13 formation" EXACT [] synonym: "positive regulation of interleukin-13 synthesis" EXACT [] synonym: "stimulation of interleukin-13 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-13 biosynthetic process" EXACT [] is_a: GO:0032736 ! positive regulation of interleukin-13 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process [Term] id: GO:0045369 name: regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "regulation of IL-14 biosynthesis" EXACT [] synonym: "regulation of IL-14 biosynthetic process" EXACT [] synonym: "regulation of interleukin-14 anabolism" EXACT [] synonym: "regulation of interleukin-14 biosynthesis" EXACT [] synonym: "regulation of interleukin-14 formation" EXACT [] synonym: "regulation of interleukin-14 synthesis" EXACT [] is_a: GO:0032657 ! regulation of interleukin-14 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042232 ! interleukin-14 biosynthetic process relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045370 name: negative regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "down regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-14 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-14 biosynthetic process" NARROW [] synonym: "negative regulation of IL-14 biosynthesis" EXACT [] synonym: "negative regulation of IL-14 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-14 anabolism" EXACT [] synonym: "negative regulation of interleukin-14 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-14 formation" EXACT [] synonym: "negative regulation of interleukin-14 synthesis" EXACT [] is_a: GO:0032697 ! negative regulation of interleukin-14 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045371 name: positive regulation of interleukin-14 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] synonym: "activation of interleukin-14 biosynthetic process" NARROW [] synonym: "positive regulation of IL-14 biosynthesis" EXACT [] synonym: "positive regulation of IL-14 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-14 anabolism" EXACT [] synonym: "positive regulation of interleukin-14 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-14 formation" EXACT [] synonym: "positive regulation of interleukin-14 synthesis" EXACT [] synonym: "stimulation of interleukin-14 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-14 biosynthetic process" EXACT [] is_a: GO:0032737 ! positive regulation of interleukin-14 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process [Term] id: GO:0045372 name: regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "regulation of IL-15 biosynthesis" EXACT [] synonym: "regulation of IL-15 biosynthetic process" EXACT [] synonym: "regulation of interleukin-15 anabolism" EXACT [] synonym: "regulation of interleukin-15 biosynthesis" EXACT [] synonym: "regulation of interleukin-15 formation" EXACT [] synonym: "regulation of interleukin-15 synthesis" EXACT [] is_a: GO:0032658 ! regulation of interleukin-15 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042233 ! interleukin-15 biosynthetic process relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045373 name: negative regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "down regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-15 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-15 biosynthetic process" NARROW [] synonym: "negative regulation of IL-15 biosynthesis" EXACT [] synonym: "negative regulation of IL-15 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-15 anabolism" EXACT [] synonym: "negative regulation of interleukin-15 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-15 formation" EXACT [] synonym: "negative regulation of interleukin-15 synthesis" EXACT [] is_a: GO:0032698 ! negative regulation of interleukin-15 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045374 name: positive regulation of interleukin-15 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] synonym: "activation of interleukin-15 biosynthetic process" NARROW [] synonym: "positive regulation of IL-15 biosynthesis" EXACT [] synonym: "positive regulation of IL-15 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-15 anabolism" EXACT [] synonym: "positive regulation of interleukin-15 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-15 formation" EXACT [] synonym: "positive regulation of interleukin-15 synthesis" EXACT [] synonym: "stimulation of interleukin-15 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-15 biosynthetic process" EXACT [] is_a: GO:0032738 ! positive regulation of interleukin-15 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process [Term] id: GO:0045375 name: regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "regulation of IL-16 biosynthesis" EXACT [] synonym: "regulation of IL-16 biosynthetic process" EXACT [] synonym: "regulation of interleukin-16 anabolism" EXACT [] synonym: "regulation of interleukin-16 biosynthesis" EXACT [] synonym: "regulation of interleukin-16 formation" EXACT [] synonym: "regulation of interleukin-16 synthesis" EXACT [] is_a: GO:0032659 ! regulation of interleukin-16 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042234 ! interleukin-16 biosynthetic process relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045376 name: negative regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "down regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-16 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-16 biosynthetic process" NARROW [] synonym: "negative regulation of IL-16 biosynthesis" EXACT [] synonym: "negative regulation of IL-16 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-16 anabolism" EXACT [] synonym: "negative regulation of interleukin-16 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-16 formation" EXACT [] synonym: "negative regulation of interleukin-16 synthesis" EXACT [] is_a: GO:0032699 ! negative regulation of interleukin-16 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045377 name: positive regulation of interleukin-16 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] synonym: "activation of interleukin-16 biosynthetic process" NARROW [] synonym: "positive regulation of IL-16 biosynthesis" EXACT [] synonym: "positive regulation of IL-16 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-16 anabolism" EXACT [] synonym: "positive regulation of interleukin-16 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-16 formation" EXACT [] synonym: "positive regulation of interleukin-16 synthesis" EXACT [] synonym: "stimulation of interleukin-16 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-16 biosynthetic process" EXACT [] is_a: GO:0032739 ! positive regulation of interleukin-16 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process [Term] id: GO:0045378 name: regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] synonym: "regulation of IL-17 biosynthesis" EXACT [] synonym: "regulation of IL-17 biosynthetic process" EXACT [] synonym: "regulation of interleukin-17 anabolism" EXACT [] synonym: "regulation of interleukin-17 biosynthesis" EXACT [] synonym: "regulation of interleukin-17 formation" EXACT [] synonym: "regulation of interleukin-17 synthesis" EXACT [] is_a: GO:0032660 ! regulation of interleukin-17 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042235 ! interleukin-17 biosynthetic process relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045379 name: negative regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] synonym: "down regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-17 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-17 biosynthetic process" NARROW [] synonym: "negative regulation of IL-17 biosynthesis" EXACT [] synonym: "negative regulation of IL-17 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-17 anabolism" EXACT [] synonym: "negative regulation of interleukin-17 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-17 formation" EXACT [] synonym: "negative regulation of interleukin-17 synthesis" EXACT [] is_a: GO:0032700 ! negative regulation of interleukin-17 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045380 name: positive regulation of interleukin-17 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] synonym: "activation of interleukin-17 biosynthetic process" NARROW [] synonym: "positive regulation of IL-17 biosynthesis" EXACT [] synonym: "positive regulation of IL-17 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-17 anabolism" EXACT [] synonym: "positive regulation of interleukin-17 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-17 formation" EXACT [] synonym: "positive regulation of interleukin-17 synthesis" EXACT [] synonym: "stimulation of interleukin-17 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-17 biosynthetic process" EXACT [] is_a: GO:0032740 ! positive regulation of interleukin-17 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process [Term] id: GO:0045381 name: regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "regulation of IL-18 biosynthesis" EXACT [] synonym: "regulation of IL-18 biosynthetic process" EXACT [] synonym: "regulation of interleukin-18 anabolism" EXACT [] synonym: "regulation of interleukin-18 biosynthesis" EXACT [] synonym: "regulation of interleukin-18 formation" EXACT [] synonym: "regulation of interleukin-18 synthesis" EXACT [] is_a: GO:0032661 ! regulation of interleukin-18 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042241 ! interleukin-18 biosynthetic process relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045382 name: negative regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "down regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-18 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-18 biosynthetic process" NARROW [] synonym: "negative regulation of IL-18 biosynthesis" EXACT [] synonym: "negative regulation of IL-18 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-18 anabolism" EXACT [] synonym: "negative regulation of interleukin-18 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-18 formation" EXACT [] synonym: "negative regulation of interleukin-18 synthesis" EXACT [] is_a: GO:0032701 ! negative regulation of interleukin-18 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045383 name: positive regulation of interleukin-18 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] synonym: "activation of interleukin-18 biosynthetic process" NARROW [] synonym: "positive regulation of IL-18 biosynthesis" EXACT [] synonym: "positive regulation of IL-18 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-18 anabolism" EXACT [] synonym: "positive regulation of interleukin-18 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-18 formation" EXACT [] synonym: "positive regulation of interleukin-18 synthesis" EXACT [] synonym: "stimulation of interleukin-18 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-18 biosynthetic process" EXACT [] is_a: GO:0032741 ! positive regulation of interleukin-18 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process [Term] id: GO:0045384 name: regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "regulation of IL-19 biosynthesis" EXACT [] synonym: "regulation of IL-19 biosynthetic process" EXACT [] synonym: "regulation of interleukin-19 anabolism" EXACT [] synonym: "regulation of interleukin-19 biosynthesis" EXACT [] synonym: "regulation of interleukin-19 formation" EXACT [] synonym: "regulation of interleukin-19 synthesis" EXACT [] is_a: GO:0032662 ! regulation of interleukin-19 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042236 ! interleukin-19 biosynthetic process relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045385 name: negative regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "down regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-19 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-19 biosynthetic process" NARROW [] synonym: "negative regulation of IL-19 biosynthesis" EXACT [] synonym: "negative regulation of IL-19 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-19 anabolism" EXACT [] synonym: "negative regulation of interleukin-19 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-19 formation" EXACT [] synonym: "negative regulation of interleukin-19 synthesis" EXACT [] is_a: GO:0032702 ! negative regulation of interleukin-19 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045386 name: positive regulation of interleukin-19 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] synonym: "activation of interleukin-19 biosynthetic process" NARROW [] synonym: "positive regulation of IL-19 biosynthesis" EXACT [] synonym: "positive regulation of IL-19 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-19 anabolism" EXACT [] synonym: "positive regulation of interleukin-19 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-19 formation" EXACT [] synonym: "positive regulation of interleukin-19 synthesis" EXACT [] synonym: "stimulation of interleukin-19 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-19 biosynthetic process" EXACT [] is_a: GO:0032742 ! positive regulation of interleukin-19 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process [Term] id: GO:0045387 name: regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "regulation of IL-20 biosynthesis" EXACT [] synonym: "regulation of IL-20 biosynthetic process" EXACT [] synonym: "regulation of interleukin-20 anabolism" EXACT [] synonym: "regulation of interleukin-20 biosynthesis" EXACT [] synonym: "regulation of interleukin-20 formation" EXACT [] synonym: "regulation of interleukin-20 synthesis" EXACT [] is_a: GO:0032664 ! regulation of interleukin-20 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042237 ! interleukin-20 biosynthetic process relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045388 name: negative regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "down regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-20 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-20 biosynthetic process" NARROW [] synonym: "negative regulation of IL-20 biosynthesis" EXACT [] synonym: "negative regulation of IL-20 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-20 anabolism" EXACT [] synonym: "negative regulation of interleukin-20 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-20 formation" EXACT [] synonym: "negative regulation of interleukin-20 synthesis" EXACT [] is_a: GO:0032704 ! negative regulation of interleukin-20 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045389 name: positive regulation of interleukin-20 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] synonym: "activation of interleukin-20 biosynthetic process" NARROW [] synonym: "positive regulation of IL-20 biosynthesis" EXACT [] synonym: "positive regulation of IL-20 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-20 anabolism" EXACT [] synonym: "positive regulation of interleukin-20 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-20 formation" EXACT [] synonym: "positive regulation of interleukin-20 synthesis" EXACT [] synonym: "stimulation of interleukin-20 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-20 biosynthetic process" EXACT [] is_a: GO:0032744 ! positive regulation of interleukin-20 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process [Term] id: GO:0045390 name: regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "regulation of IL-21 biosynthesis" EXACT [] synonym: "regulation of IL-21 biosynthetic process" EXACT [] synonym: "regulation of interleukin-21 anabolism" EXACT [] synonym: "regulation of interleukin-21 biosynthesis" EXACT [] synonym: "regulation of interleukin-21 formation" EXACT [] synonym: "regulation of interleukin-21 synthesis" EXACT [] is_a: GO:0032665 ! regulation of interleukin-21 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042238 ! interleukin-21 biosynthetic process relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045391 name: negative regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "down regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-21 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-21 biosynthetic process" NARROW [] synonym: "negative regulation of IL-21 biosynthesis" EXACT [] synonym: "negative regulation of IL-21 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-21 anabolism" EXACT [] synonym: "negative regulation of interleukin-21 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-21 formation" EXACT [] synonym: "negative regulation of interleukin-21 synthesis" EXACT [] is_a: GO:0032705 ! negative regulation of interleukin-21 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045392 name: positive regulation of interleukin-21 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] synonym: "activation of interleukin-21 biosynthetic process" NARROW [] synonym: "positive regulation of IL-21 biosynthesis" EXACT [] synonym: "positive regulation of IL-21 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-21 anabolism" EXACT [] synonym: "positive regulation of interleukin-21 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-21 formation" EXACT [] synonym: "positive regulation of interleukin-21 synthesis" EXACT [] synonym: "stimulation of interleukin-21 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-21 biosynthetic process" EXACT [] is_a: GO:0032745 ! positive regulation of interleukin-21 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process [Term] id: GO:0045393 name: regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "regulation of IL-22 biosynthesis" EXACT [] synonym: "regulation of IL-22 biosynthetic process" EXACT [] synonym: "regulation of interleukin-22 anabolism" EXACT [] synonym: "regulation of interleukin-22 biosynthesis" EXACT [] synonym: "regulation of interleukin-22 formation" EXACT [] synonym: "regulation of interleukin-22 synthesis" EXACT [] is_a: GO:0032666 ! regulation of interleukin-22 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042239 ! interleukin-22 biosynthetic process relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045394 name: negative regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "down regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-22 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-22 biosynthetic process" NARROW [] synonym: "negative regulation of IL-22 biosynthesis" EXACT [] synonym: "negative regulation of IL-22 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-22 anabolism" EXACT [] synonym: "negative regulation of interleukin-22 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-22 formation" EXACT [] synonym: "negative regulation of interleukin-22 synthesis" EXACT [] is_a: GO:0032706 ! negative regulation of interleukin-22 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045395 name: positive regulation of interleukin-22 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] synonym: "activation of interleukin-22 biosynthetic process" NARROW [] synonym: "positive regulation of IL-22 biosynthesis" EXACT [] synonym: "positive regulation of IL-22 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-22 anabolism" EXACT [] synonym: "positive regulation of interleukin-22 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-22 formation" EXACT [] synonym: "positive regulation of interleukin-22 synthesis" EXACT [] synonym: "stimulation of interleukin-22 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-22 biosynthetic process" EXACT [] is_a: GO:0032746 ! positive regulation of interleukin-22 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process [Term] id: GO:0045396 name: regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "regulation of IL-23 biosynthesis" EXACT [] synonym: "regulation of IL-23 biosynthetic process" EXACT [] synonym: "regulation of interleukin-23 anabolism" EXACT [] synonym: "regulation of interleukin-23 biosynthesis" EXACT [] synonym: "regulation of interleukin-23 formation" EXACT [] synonym: "regulation of interleukin-23 synthesis" EXACT [] is_a: GO:0032667 ! regulation of interleukin-23 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042240 ! interleukin-23 biosynthetic process relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045397 name: negative regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "down regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-23 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-23 biosynthetic process" NARROW [] synonym: "negative regulation of IL-23 biosynthesis" EXACT [] synonym: "negative regulation of IL-23 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-23 anabolism" EXACT [] synonym: "negative regulation of interleukin-23 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-23 formation" EXACT [] synonym: "negative regulation of interleukin-23 synthesis" EXACT [] is_a: GO:0032707 ! negative regulation of interleukin-23 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045398 name: positive regulation of interleukin-23 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] synonym: "activation of interleukin-23 biosynthetic process" NARROW [] synonym: "positive regulation of IL-23 biosynthesis" EXACT [] synonym: "positive regulation of IL-23 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-23 anabolism" EXACT [] synonym: "positive regulation of interleukin-23 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-23 formation" EXACT [] synonym: "positive regulation of interleukin-23 synthesis" EXACT [] synonym: "stimulation of interleukin-23 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-23 biosynthetic process" EXACT [] is_a: GO:0032747 ! positive regulation of interleukin-23 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process [Term] id: GO:0045399 name: regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "regulation of IL-3 biosynthesis" EXACT [] synonym: "regulation of IL-3 biosynthetic process" EXACT [] synonym: "regulation of interleukin-3 anabolism" EXACT [] synonym: "regulation of interleukin-3 biosynthesis" EXACT [] synonym: "regulation of interleukin-3 formation" EXACT [] synonym: "regulation of interleukin-3 synthesis" EXACT [] is_a: GO:0032672 ! regulation of interleukin-3 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042223 ! interleukin-3 biosynthetic process relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045400 name: negative regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "down regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-3 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-3 biosynthetic process" NARROW [] synonym: "negative regulation of IL-3 biosynthesis" EXACT [] synonym: "negative regulation of IL-3 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-3 anabolism" EXACT [] synonym: "negative regulation of interleukin-3 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-3 formation" EXACT [] synonym: "negative regulation of interleukin-3 synthesis" EXACT [] is_a: GO:0032712 ! negative regulation of interleukin-3 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045401 name: positive regulation of interleukin-3 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] synonym: "activation of interleukin-3 biosynthetic process" NARROW [] synonym: "positive regulation of IL-3 biosynthesis" EXACT [] synonym: "positive regulation of IL-3 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-3 anabolism" EXACT [] synonym: "positive regulation of interleukin-3 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-3 formation" EXACT [] synonym: "positive regulation of interleukin-3 synthesis" EXACT [] synonym: "stimulation of interleukin-3 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-3 biosynthetic process" EXACT [] is_a: GO:0032752 ! positive regulation of interleukin-3 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process [Term] id: GO:0045402 name: regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "regulation of IL-4 biosynthesis" EXACT [] synonym: "regulation of IL-4 biosynthetic process" EXACT [] synonym: "regulation of interleukin-4 anabolism" EXACT [] synonym: "regulation of interleukin-4 biosynthesis" EXACT [] synonym: "regulation of interleukin-4 formation" EXACT [] synonym: "regulation of interleukin-4 synthesis" EXACT [] is_a: GO:0032673 ! regulation of interleukin-4 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042097 ! interleukin-4 biosynthetic process relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045403 name: negative regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "down regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-4 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-4 biosynthetic process" NARROW [] synonym: "negative regulation of IL-4 biosynthesis" EXACT [] synonym: "negative regulation of IL-4 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-4 anabolism" EXACT [] synonym: "negative regulation of interleukin-4 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-4 formation" EXACT [] synonym: "negative regulation of interleukin-4 synthesis" EXACT [] is_a: GO:0032713 ! negative regulation of interleukin-4 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045404 name: positive regulation of interleukin-4 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] synonym: "activation of interleukin-4 biosynthetic process" NARROW [] synonym: "positive regulation of IL-4 biosynthesis" EXACT [] synonym: "positive regulation of IL-4 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-4 anabolism" EXACT [] synonym: "positive regulation of interleukin-4 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-4 formation" EXACT [] synonym: "positive regulation of interleukin-4 synthesis" EXACT [] synonym: "stimulation of interleukin-4 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-4 biosynthetic process" EXACT [] is_a: GO:0032753 ! positive regulation of interleukin-4 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process [Term] id: GO:0045405 name: regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "regulation of IL-5 biosynthesis" EXACT [] synonym: "regulation of IL-5 biosynthetic process" EXACT [] synonym: "regulation of interleukin-5 anabolism" EXACT [] synonym: "regulation of interleukin-5 biosynthesis" EXACT [] synonym: "regulation of interleukin-5 formation" EXACT [] synonym: "regulation of interleukin-5 synthesis" EXACT [] is_a: GO:0032674 ! regulation of interleukin-5 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042225 ! interleukin-5 biosynthetic process relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045406 name: negative regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "down regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-5 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-5 biosynthetic process" NARROW [] synonym: "negative regulation of IL-5 biosynthesis" EXACT [] synonym: "negative regulation of IL-5 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-5 anabolism" EXACT [] synonym: "negative regulation of interleukin-5 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-5 formation" EXACT [] synonym: "negative regulation of interleukin-5 synthesis" EXACT [] is_a: GO:0032714 ! negative regulation of interleukin-5 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045407 name: positive regulation of interleukin-5 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] synonym: "activation of interleukin-5 biosynthetic process" NARROW [] synonym: "positive regulation of IL-5 biosynthesis" EXACT [] synonym: "positive regulation of IL-5 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-5 anabolism" EXACT [] synonym: "positive regulation of interleukin-5 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-5 formation" EXACT [] synonym: "positive regulation of interleukin-5 synthesis" EXACT [] synonym: "stimulation of interleukin-5 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-5 biosynthetic process" EXACT [] is_a: GO:0032754 ! positive regulation of interleukin-5 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process [Term] id: GO:0045408 name: regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "regulation of IL-6 biosynthesis" EXACT [] synonym: "regulation of IL-6 biosynthetic process" EXACT [] synonym: "regulation of interleukin-6 anabolism" EXACT [] synonym: "regulation of interleukin-6 biosynthesis" EXACT [] synonym: "regulation of interleukin-6 formation" EXACT [] synonym: "regulation of interleukin-6 synthesis" EXACT [] is_a: GO:0032675 ! regulation of interleukin-6 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042226 ! interleukin-6 biosynthetic process relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045409 name: negative regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "down regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-6 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-6 biosynthetic process" NARROW [] synonym: "negative regulation of IL-6 biosynthesis" EXACT [] synonym: "negative regulation of IL-6 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-6 anabolism" EXACT [] synonym: "negative regulation of interleukin-6 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-6 formation" EXACT [] synonym: "negative regulation of interleukin-6 synthesis" EXACT [] is_a: GO:0032715 ! negative regulation of interleukin-6 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045410 name: positive regulation of interleukin-6 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] synonym: "activation of interleukin-6 biosynthetic process" NARROW [] synonym: "positive regulation of IL-6 biosynthesis" EXACT [] synonym: "positive regulation of IL-6 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-6 anabolism" EXACT [] synonym: "positive regulation of interleukin-6 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-6 formation" EXACT [] synonym: "positive regulation of interleukin-6 synthesis" EXACT [] synonym: "stimulation of interleukin-6 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-6 biosynthetic process" EXACT [] is_a: GO:0032755 ! positive regulation of interleukin-6 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process [Term] id: GO:0045411 name: regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "regulation of IL-7 biosynthesis" EXACT [] synonym: "regulation of IL-7 biosynthetic process" EXACT [] synonym: "regulation of interleukin-7 anabolism" EXACT [] synonym: "regulation of interleukin-7 biosynthesis" EXACT [] synonym: "regulation of interleukin-7 formation" EXACT [] synonym: "regulation of interleukin-7 synthesis" EXACT [] is_a: GO:0032676 ! regulation of interleukin-7 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042227 ! interleukin-7 biosynthetic process relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045412 name: negative regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "down regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-7 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-7 biosynthetic process" NARROW [] synonym: "negative regulation of IL-7 biosynthesis" EXACT [] synonym: "negative regulation of IL-7 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-7 anabolism" EXACT [] synonym: "negative regulation of interleukin-7 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-7 formation" EXACT [] synonym: "negative regulation of interleukin-7 synthesis" EXACT [] is_a: GO:0032716 ! negative regulation of interleukin-7 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045413 name: positive regulation of interleukin-7 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] synonym: "activation of interleukin-7 biosynthetic process" NARROW [] synonym: "positive regulation of IL-7 biosynthesis" EXACT [] synonym: "positive regulation of IL-7 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-7 anabolism" EXACT [] synonym: "positive regulation of interleukin-7 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-7 formation" EXACT [] synonym: "positive regulation of interleukin-7 synthesis" EXACT [] synonym: "stimulation of interleukin-7 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-7 biosynthetic process" EXACT [] is_a: GO:0032756 ! positive regulation of interleukin-7 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process [Term] id: GO:0045414 name: regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "regulation of IL-8 biosynthesis" EXACT [] synonym: "regulation of IL-8 biosynthetic process" EXACT [] synonym: "regulation of interleukin-8 anabolism" EXACT [] synonym: "regulation of interleukin-8 biosynthesis" EXACT [] synonym: "regulation of interleukin-8 formation" EXACT [] synonym: "regulation of interleukin-8 synthesis" EXACT [] is_a: GO:0032677 ! regulation of interleukin-8 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042228 ! interleukin-8 biosynthetic process relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045415 name: negative regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "down regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-8 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-8 biosynthetic process" NARROW [] synonym: "negative regulation of IL-8 biosynthesis" EXACT [] synonym: "negative regulation of IL-8 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-8 anabolism" EXACT [] synonym: "negative regulation of interleukin-8 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-8 formation" EXACT [] synonym: "negative regulation of interleukin-8 synthesis" EXACT [] is_a: GO:0032717 ! negative regulation of interleukin-8 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045416 name: positive regulation of interleukin-8 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] synonym: "activation of interleukin-8 biosynthetic process" NARROW [] synonym: "positive regulation of IL-8 biosynthesis" EXACT [] synonym: "positive regulation of IL-8 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-8 anabolism" EXACT [] synonym: "positive regulation of interleukin-8 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-8 formation" EXACT [] synonym: "positive regulation of interleukin-8 synthesis" EXACT [] synonym: "stimulation of interleukin-8 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-8 biosynthetic process" EXACT [] is_a: GO:0032757 ! positive regulation of interleukin-8 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process [Term] id: GO:0045417 name: regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "regulation of IL-9 biosynthesis" EXACT [] synonym: "regulation of IL-9 biosynthetic process" EXACT [] synonym: "regulation of interleukin-9 anabolism" EXACT [] synonym: "regulation of interleukin-9 biosynthesis" EXACT [] synonym: "regulation of interleukin-9 formation" EXACT [] synonym: "regulation of interleukin-9 synthesis" EXACT [] is_a: GO:0032678 ! regulation of interleukin-9 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042229 ! interleukin-9 biosynthetic process relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045418 name: negative regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "down regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-9 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-9 biosynthetic process" NARROW [] synonym: "negative regulation of IL-9 biosynthesis" EXACT [] synonym: "negative regulation of IL-9 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-9 anabolism" EXACT [] synonym: "negative regulation of interleukin-9 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-9 formation" EXACT [] synonym: "negative regulation of interleukin-9 synthesis" EXACT [] is_a: GO:0032718 ! negative regulation of interleukin-9 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045419 name: positive regulation of interleukin-9 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] synonym: "activation of interleukin-9 biosynthetic process" NARROW [] synonym: "positive regulation of IL-9 biosynthesis" EXACT [] synonym: "positive regulation of IL-9 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-9 anabolism" EXACT [] synonym: "positive regulation of interleukin-9 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-9 formation" EXACT [] synonym: "positive regulation of interleukin-9 synthesis" EXACT [] synonym: "stimulation of interleukin-9 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-9 biosynthetic process" EXACT [] is_a: GO:0032758 ! positive regulation of interleukin-9 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process [Term] id: GO:0045420 name: regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "regulation of connective tissue growth factor anabolism" EXACT [] synonym: "regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "regulation of connective tissue growth factor formation" EXACT [] synonym: "regulation of connective tissue growth factor synthesis" EXACT [] is_a: GO:0032643 ! regulation of connective tissue growth factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045189 ! connective tissue growth factor biosynthetic process relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045421 name: negative regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW [] synonym: "negative regulation of connective tissue growth factor anabolism" EXACT [] synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "negative regulation of connective tissue growth factor formation" EXACT [] synonym: "negative regulation of connective tissue growth factor synthesis" EXACT [] is_a: GO:0032683 ! negative regulation of connective tissue growth factor production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045422 name: positive regulation of connective tissue growth factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] synonym: "activation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "positive regulation of connective tissue growth factor anabolism" EXACT [] synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT [] synonym: "positive regulation of connective tissue growth factor formation" EXACT [] synonym: "positive regulation of connective tissue growth factor synthesis" EXACT [] synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT [] synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT [] is_a: GO:0032723 ! positive regulation of connective tissue growth factor production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process [Term] id: GO:0045423 name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "regulation of GM-CSF biosynthesis" EXACT [GOC:vk] synonym: "regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process relationship: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045424 name: negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "down regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "down-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "downregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "inhibition of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "negative regulation of GM-CSF biosynthesis" EXACT [GOC:vk] synonym: "negative regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "negative regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] is_a: GO:0032685 ! negative regulation of granulocyte macrophage colony-stimulating factor production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process relationship: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045425 name: positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] synonym: "activation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "positive regulation of GM-CSF biosynthesis" RELATED [GOC:vk] synonym: "positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] synonym: "positive regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] synonym: "stimulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] synonym: "up regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "up-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] synonym: "upregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] is_a: GO:0032725 ! positive regulation of granulocyte macrophage colony-stimulating factor production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process relationship: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process [Term] id: GO:0045427 name: enzyme active site formation via (phospho-5'-guanosine)-L-histidine namespace: biological_process def: "The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098825 ! peptidyl-histidine guanylation [Term] id: GO:0045428 name: regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "regulation of nitric oxide anabolism" EXACT [] synonym: "regulation of nitric oxide biosynthesis" EXACT [] synonym: "regulation of nitric oxide formation" EXACT [] synonym: "regulation of nitric oxide synthesis" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006809 ! nitric oxide biosynthetic process relationship: regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045429 name: positive regulation of nitric oxide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] synonym: "activation of nitric oxide biosynthetic process" NARROW [] synonym: "positive regulation of nitric oxide anabolism" EXACT [] synonym: "positive regulation of nitric oxide biosynthesis" EXACT [] synonym: "positive regulation of nitric oxide formation" EXACT [] synonym: "positive regulation of nitric oxide synthesis" EXACT [] synonym: "stimulation of nitric oxide biosynthetic process" NARROW [] synonym: "up regulation of nitric oxide biosynthetic process" EXACT [] synonym: "up-regulation of nitric oxide biosynthetic process" EXACT [] synonym: "upregulation of nitric oxide biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process is_a: GO:1904407 ! positive regulation of nitric oxide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006809 ! nitric oxide biosynthetic process relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process [Term] id: GO:0045430 name: chalcone isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6] synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6] synonym: "chalcone-flavanone isomerase activity" EXACT [] synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6] xref: EC:5.5.1.6 xref: MetaCyc:CHALCONE-ISOMERASE-RXN is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0045431 name: flavonol synthase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.20.6, ISBN:0943088372, PMID:7904213] synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.20.6] synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.20.6] synonym: "FLS activity" RELATED [EC:1.14.20.6] xref: EC:1.14.20.6 xref: RHEA:21088 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity relationship: part_of GO:0051555 ! flavonol biosynthetic process [Term] id: GO:0045433 name: male courtship behavior, veined wing generated song production namespace: biological_process def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, song production" BROAD [] synonym: "male courtship behaviour, song production" BROAD [] synonym: "male courtship behaviour, veined wing generated song production" EXACT [] is_a: GO:0008049 ! male courtship behavior relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration [Term] id: GO:0045434 name: negative regulation of female receptivity, post-mating namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity, post-mating" EXACT [] synonym: "down-regulation of female receptivity, post-mating" EXACT [] synonym: "downregulation of female receptivity, post-mating" EXACT [] synonym: "inhibition of female receptivity, post-mating" NARROW [] is_a: GO:0007621 ! negative regulation of female receptivity is_a: GO:0046008 ! regulation of female receptivity, post-mating [Term] id: GO:0045435 name: lycopene epsilon cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512] synonym: "lycopene cyclase" BROAD [] is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0045436 name: lycopene beta cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512] synonym: "crtL" RELATED [] synonym: "lycopene cyclase" BROAD [] xref: MetaCyc:RXN1F-150 is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0045437 name: uridine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil." [EC:3.2.2.3, RHEA:15577] synonym: "uridine hydrolase activity" EXACT [] synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3] xref: EC:3.2.2.3 xref: KEGG_REACTION:R01080 xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN xref: RHEA:15577 is_a: GO:0050263 ! ribosylpyrimidine nucleosidase activity [Term] id: GO:0045438 name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity namespace: molecular_function def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333] synonym: "ACV synthetase activity" BROAD [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0045439 name: isopenicillin-N epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isopenicillin N = penicillin N." [EC:5.1.1.17, RHEA:20033] synonym: "isopenicillin N epimerase activity" EXACT [] synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17] xref: EC:5.1.1.17 xref: KEGG_REACTION:R04147 xref: MetaCyc:5.1.1.17-RXN xref: RHEA:20033 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0045442 name: deacetoxycephalosporin-C hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate." [EC:1.14.11.26, RHEA:16805] synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "beta-lactam hydroxylase activity" EXACT [] synonym: "DACS" RELATED [EC:1.14.11.26] synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26] synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26] synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26] xref: EC:1.14.11.26 xref: KEGG_REACTION:R05229 xref: MetaCyc:1.14.11.26-RXN xref: RHEA:16805 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0045443 name: juvenile hormone secretion namespace: biological_process def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] is_a: GO:0046865 ! terpenoid transport is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell [Term] id: GO:0045444 name: fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] synonym: "adipocyte cell differentiation" EXACT [] synonym: "adipocyte differentiation" EXACT [] synonym: "adipogenesis" RELATED [] synonym: "adipose cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0045445 name: myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "myoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0061061 ! muscle structure development [Term] id: GO:0045446 name: endothelial cell differentiation namespace: biological_process def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0003158 ! endothelium development [Term] id: GO:0045448 name: mitotic cell cycle, embryonic namespace: biological_process def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] is_a: GO:0000278 ! mitotic cell cycle relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0045450 name: bicoid mRNA localization namespace: biological_process def: "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] synonym: "bicoid mRNA localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of bicoid mRNA localization" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0045451 name: pole plasm oskar mRNA localization namespace: biological_process def: "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT [] synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT [] synonym: "oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0045453 name: bone resorption namespace: biological_process def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] xref: Wikipedia:Bone_resorption is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0046849 ! bone remodeling [Term] id: GO:0045454 name: cell redox homeostasis namespace: biological_process alt_id: GO:0030503 alt_id: GO:0045867 alt_id: GO:0045868 def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_drosophila subset: goslim_metagenomics synonym: "regulation of cell redox homeostasis" RELATED [] synonym: "regulation of redox homeostasis" BROAD [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0045455 name: ecdysteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] synonym: "ecdysteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042180 ! cellular ketone metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development [Term] id: GO:0045456 name: ecdysteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] synonym: "ecdysteroid anabolism" EXACT [] synonym: "ecdysteroid biosynthesis" EXACT [] synonym: "ecdysteroid formation" EXACT [] synonym: "ecdysteroid synthesis" EXACT [] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0045455 ! ecdysteroid metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0045457 name: ecdysteroid secretion namespace: biological_process def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] is_a: GO:0035929 ! steroid hormone secretion [Term] id: GO:0045458 name: recombination within rDNA repeats namespace: biological_process def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: Note that this term was reinstated from obsolete. synonym: "recombination within ribosomal DNA repeats" EXACT [] is_a: GO:0006310 ! DNA recombination is_a: GO:0043007 ! maintenance of rDNA [Term] id: GO:0045459 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide namespace: biological_process def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326] synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT [] xref: RESID:AA0326 is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0045460 name: sterigmatocystin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248] synonym: "sterigmatocystin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process [Term] id: GO:0045461 name: sterigmatocystin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248] synonym: "sterigmatocystin anabolism" EXACT [] synonym: "sterigmatocystin biosynthesis" EXACT [] synonym: "sterigmatocystin formation" EXACT [] synonym: "sterigmatocystin synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0045460 ! sterigmatocystin metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process [Term] id: GO:0045462 name: trichothecene 3-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0045463 name: R8 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0045464 name: R8 cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] is_a: GO:0043704 ! photoreceptor cell fate specification relationship: part_of GO:0007460 ! R8 cell fate commitment [Term] id: GO:0045465 name: R8 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0045466 name: R7 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0045467 name: R7 cell development namespace: biological_process def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0045468 name: regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339] synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb] synonym: "regulation of R8 spacing" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0045469 name: negative regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339] synonym: "down regulation of R8 spacing" EXACT [] synonym: "down-regulation of R8 spacing" EXACT [] synonym: "downregulation of R8 spacing" EXACT [] synonym: "inhibition of R8 spacing" NARROW [] is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye [Term] id: GO:0045470 name: R8 cell-mediated photoreceptor organization namespace: biological_process def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339] synonym: "R8-mediated photoreceptor organisation" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0042051 ! compound eye photoreceptor development [Term] id: GO:0045471 name: response to ethanol namespace: biological_process alt_id: GO:0017036 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] is_a: GO:0009636 ! response to toxic substance is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol [Term] id: GO:0045472 name: response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0045473 name: obsolete response to ethanol (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "response to ethanol (sensu Insecta)" EXACT [] is_obsolete: true consider: GO:0048149 [Term] id: GO:0045474 name: obsolete response to ether (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "response to ether (sensu Insecta)" EXACT [] is_obsolete: true consider: GO:0048150 [Term] id: GO:0045475 name: locomotor rhythm namespace: biological_process def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] synonym: "circadian locomotor activity rhythm" NARROW [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0048512 ! circadian behavior [Term] id: GO:0045476 name: nurse cell apoptotic process namespace: biological_process def: "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] synonym: "apoptosis of nurse cells" EXACT [] synonym: "invertebrate nurse cell apoptosis" NARROW [] synonym: "nurse cell apoptosis" NARROW [] synonym: "nurse cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of nurse cells by apoptosis" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:1902742 ! apoptotic process involved in development relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0045477 name: regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306] synonym: "regulation of nurse cell apoptosis" NARROW [] is_a: GO:1904748 ! regulation of apoptotic process involved in development is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045476 ! nurse cell apoptotic process relationship: regulates GO:0045476 ! nurse cell apoptotic process [Term] id: GO:0045478 name: fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] subset: goslim_pir synonym: "fusome organisation" EXACT [] synonym: "fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism [Term] id: GO:0045479 name: vesicle targeting to fusome namespace: biological_process def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244] synonym: "vesicle-fusome targeting" EXACT [] is_a: GO:0006903 ! vesicle targeting is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0045478 ! fusome organization [Term] id: GO:0045480 name: galactose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9] synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9] synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9] synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9] xref: EC:1.1.3.9 xref: MetaCyc:GALACTOSE-OXIDASE-RXN xref: RHEA:24160 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0045481 name: 6-endo-hydroxycineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH." [EC:1.1.1.241, RHEA:11736] synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241] xref: EC:1.1.1.241 xref: KEGG_REACTION:R02994 xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN xref: RHEA:11736 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045482 name: trichodiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene." [EC:4.2.3.6, RHEA:12052] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6] synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6] synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6] xref: EC:4.2.3.6 xref: KEGG_REACTION:R02306 xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN xref: RHEA:12052 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0045483 name: aristolochene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9] synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9] synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] xref: EC:4.2.3.9 xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN xref: RHEA:19825 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0045484 name: L-lysine 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine." [EC:2.6.1.36, RHEA:21200] synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine 6-aminotransferase activity" EXACT [] synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36] synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36] synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] xref: EC:2.6.1.36 xref: KEGG_REACTION:R00457 xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN xref: RHEA:21200 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0045485 name: omega-6 fatty acid desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158] xref: Reactome:R-HSA-2046089 "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA" xref: Reactome:R-HSA-2046092 "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0045486 name: naringenin 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9] synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9] synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9] synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9] xref: EC:1.14.11.9 xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0045487 name: gibberellin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators] synonym: "gibberellic acid breakdown" NARROW [] synonym: "gibberellic acid catabolic process" NARROW [] synonym: "gibberellic acid catabolism" NARROW [] synonym: "gibberellic acid degradation" NARROW [] synonym: "gibberellin catabolism" EXACT [] is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0045488 name: pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators] synonym: "pectin metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0045489 name: pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] synonym: "pectin anabolism" EXACT [] synonym: "pectin biosynthesis" EXACT [] synonym: "pectin formation" EXACT [] synonym: "pectin synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0045488 ! pectin metabolic process [Term] id: GO:0045490 name: pectin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] synonym: "pectin breakdown" EXACT [] synonym: "pectin catabolism" EXACT [] synonym: "pectin degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0045488 ! pectin metabolic process [Term] id: GO:0045491 name: xylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] synonym: "xylan metabolism" EXACT [] is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0045492 name: xylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] synonym: "xylan anabolism" EXACT [] synonym: "xylan biosynthesis" EXACT [] synonym: "xylan formation" EXACT [] synonym: "xylan synthesis" EXACT [] is_a: GO:0045491 ! xylan metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0045493 name: xylan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] synonym: "xylan breakdown" EXACT [] synonym: "xylan catabolism" EXACT [] synonym: "xylan degradation" EXACT [] is_a: GO:0044347 ! cell wall polysaccharide catabolic process is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0045494 name: photoreceptor cell maintenance namespace: biological_process def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0001895 ! retina homeostasis [Term] id: GO:0045495 name: pole plasm namespace: cellular_component def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] synonym: "germ plasm" NARROW [] synonym: "polar plasm" EXACT [] is_a: GO:0005737 ! cytoplasm [Term] id: GO:0045496 name: male analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0007487 ! analia development [Term] id: GO:0045497 name: female analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0007487 ! analia development [Term] id: GO:0045498 name: sex comb development namespace: biological_process def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0045499 name: chemorepellent activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai] subset: goslim_pir synonym: "chemorepellant activity" EXACT [] is_a: GO:0048018 ! receptor ligand activity relationship: part_of GO:0050919 ! negative chemotaxis [Term] id: GO:0045500 name: sevenless signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085] synonym: "sev receptor signaling pathway" EXACT [] synonym: "sev signaling pathway" EXACT [] synonym: "sevenless signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0007465 ! R7 cell fate commitment [Term] id: GO:0045501 name: regulation of sevenless signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "regulation of sev signaling pathway" EXACT [] synonym: "regulation of sevenless signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045676 ! regulation of R7 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045500 ! sevenless signaling pathway relationship: regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045503 name: dynein light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of the dynein complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045504 name: dynein heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of the dynein complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045505 name: dynein intermediate chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intermediate chain of the dynein complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0045506 name: interleukin-24 receptor activity namespace: molecular_function def: "Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-24 receptor activity" EXACT [GOC:mah] synonym: "IL-24R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0045510 ! interleukin-24 binding [Term] id: GO:0045507 name: interleukin-25 receptor activity namespace: molecular_function def: "Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-25 receptor activity" EXACT [GOC:mah] synonym: "IL-25R" EXACT [] is_a: GO:0030368 ! interleukin-17 receptor activity relationship: has_part GO:0045511 ! interleukin-25 binding [Term] id: GO:0045508 name: interleukin-26 receptor activity namespace: molecular_function def: "Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-26 receptor activity" EXACT [GOC:mah] synonym: "IL-26R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0045512 ! interleukin-26 binding [Term] id: GO:0045509 name: interleukin-27 receptor activity namespace: molecular_function def: "Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-27 receptor activity" EXACT [GOC:mah] synonym: "IL-27R" EXACT [] is_a: GO:0030368 ! interleukin-17 receptor activity relationship: has_part GO:0045513 ! interleukin-27 binding relationship: part_of GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0045510 name: interleukin-24 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-24." [GOC:go_curators] synonym: "IL-24 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045511 name: interleukin-25 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-25." [GOC:go_curators] synonym: "IL-25 binding" EXACT [] is_a: GO:0019975 ! interleukin-17 binding [Term] id: GO:0045512 name: interleukin-26 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-26." [GOC:go_curators] synonym: "IL-26 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0045513 name: interleukin-27 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-27." [GOC:go_curators] synonym: "IL-27 binding" EXACT [] is_a: GO:0019975 ! interleukin-17 binding [Term] id: GO:0045514 name: interleukin-16 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-16 receptor." [GOC:go_curators] synonym: "IL-16" NARROW [] synonym: "interleukin-16 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045515 name: interleukin-18 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-18 receptor." [GOC:go_curators] synonym: "IL-18" NARROW [] synonym: "interleukin-18 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045516 name: interleukin-19 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-19 receptor." [GOC:go_curators] synonym: "IL-19" NARROW [] synonym: "interleukin-19 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045517 name: interleukin-20 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-20 receptor." [GOC:go_curators] synonym: "IL-20" NARROW [] synonym: "interleukin-20 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045518 name: interleukin-22 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-22 receptor." [GOC:go_curators] synonym: "IL-22" NARROW [] synonym: "interleukin-22 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045519 name: interleukin-23 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-23 receptor." [GOC:go_curators] synonym: "IL-23" NARROW [] synonym: "interleukin-23 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045520 name: interleukin-24 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-24 receptor." [GOC:go_curators] synonym: "IL-24" NARROW [] synonym: "interleukin-24 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045521 name: interleukin-25 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-25 receptor." [GOC:go_curators] synonym: "IL-25" NARROW [] synonym: "interleukin-25 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045522 name: interleukin-26 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-26 receptor." [GOC:go_curators] synonym: "IL-26" NARROW [] synonym: "interleukin-26 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045523 name: interleukin-27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-27 receptor." [GOC:go_curators] synonym: "IL-27" NARROW [] synonym: "interleukin-27 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0045524 name: interleukin-24 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "IL-24 biosynthesis" EXACT [] synonym: "IL-24 biosynthetic process" EXACT [] synonym: "interleukin-24 anabolism" EXACT [] synonym: "interleukin-24 biosynthesis" EXACT [] synonym: "interleukin-24 formation" EXACT [] synonym: "interleukin-24 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032628 ! interleukin-24 production [Term] id: GO:0045525 name: interleukin-25 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "IL-25 biosynthesis" EXACT [] synonym: "IL-25 biosynthetic process" EXACT [] synonym: "interleukin-25 anabolism" EXACT [] synonym: "interleukin-25 biosynthesis" EXACT [] synonym: "interleukin-25 formation" EXACT [] synonym: "interleukin-25 synthesis" EXACT [] is_a: GO:0042235 ! interleukin-17 biosynthetic process relationship: part_of GO:0032629 ! interleukin-25 production [Term] id: GO:0045526 name: interleukin-26 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "IL-26 biosynthesis" EXACT [] synonym: "IL-26 biosynthetic process" EXACT [] synonym: "interleukin-26 anabolism" EXACT [] synonym: "interleukin-26 biosynthesis" EXACT [] synonym: "interleukin-26 formation" EXACT [] synonym: "interleukin-26 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032630 ! interleukin-26 production [Term] id: GO:0045527 name: interleukin-27 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "IL-27 biosynthesis" EXACT [] synonym: "IL-27 biosynthetic process" EXACT [] synonym: "interleukin-27 anabolism" EXACT [] synonym: "interleukin-27 biosynthesis" EXACT [] synonym: "interleukin-27 formation" EXACT [] synonym: "interleukin-27 synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032631 ! interleukin-27 production [Term] id: GO:0045528 name: regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "regulation of IL-24 biosynthesis" EXACT [] synonym: "regulation of IL-24 biosynthetic process" EXACT [] synonym: "regulation of interleukin-24 anabolism" EXACT [] synonym: "regulation of interleukin-24 biosynthesis" EXACT [] synonym: "regulation of interleukin-24 formation" EXACT [] synonym: "regulation of interleukin-24 synthesis" EXACT [] is_a: GO:0032668 ! regulation of interleukin-24 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045524 ! interleukin-24 biosynthetic process relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045529 name: regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "regulation of IL-25 biosynthesis" EXACT [] synonym: "regulation of IL-25 biosynthetic process" EXACT [] synonym: "regulation of interleukin-25 anabolism" EXACT [] synonym: "regulation of interleukin-25 biosynthesis" EXACT [] synonym: "regulation of interleukin-25 formation" EXACT [] synonym: "regulation of interleukin-25 synthesis" EXACT [] is_a: GO:0032669 ! regulation of interleukin-25 production is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045525 ! interleukin-25 biosynthetic process relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045530 name: regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "regulation of IL-26 biosynthesis" EXACT [] synonym: "regulation of IL-26 biosynthetic process" EXACT [] synonym: "regulation of interleukin-26 anabolism" EXACT [] synonym: "regulation of interleukin-26 biosynthesis" EXACT [] synonym: "regulation of interleukin-26 formation" EXACT [] synonym: "regulation of interleukin-26 synthesis" EXACT [] is_a: GO:0032670 ! regulation of interleukin-26 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045526 ! interleukin-26 biosynthetic process relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045531 name: regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "regulation of IL-27 biosynthesis" EXACT [] synonym: "regulation of IL-27 biosynthetic process" EXACT [] synonym: "regulation of interleukin-27 anabolism" EXACT [] synonym: "regulation of interleukin-27 biosynthesis" EXACT [] synonym: "regulation of interleukin-27 formation" EXACT [] synonym: "regulation of interleukin-27 synthesis" EXACT [] is_a: GO:0032671 ! regulation of interleukin-27 production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045527 ! interleukin-27 biosynthetic process relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045532 name: negative regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "down regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-24 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-24 biosynthetic process" NARROW [] synonym: "negative regulation of IL-24 biosynthesis" EXACT [] synonym: "negative regulation of IL-24 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-24 anabolism" EXACT [] synonym: "negative regulation of interleukin-24 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-24 formation" EXACT [] synonym: "negative regulation of interleukin-24 synthesis" EXACT [] is_a: GO:0032708 ! negative regulation of interleukin-24 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045533 name: negative regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "down regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-25 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-25 biosynthetic process" NARROW [] synonym: "negative regulation of IL-25 biosynthesis" EXACT [] synonym: "negative regulation of IL-25 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-25 anabolism" EXACT [] synonym: "negative regulation of interleukin-25 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-25 formation" EXACT [] synonym: "negative regulation of interleukin-25 synthesis" EXACT [] is_a: GO:0032709 ! negative regulation of interleukin-25 production is_a: GO:0045379 ! negative regulation of interleukin-17 biosynthetic process is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045534 name: negative regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "down regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-26 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-26 biosynthetic process" NARROW [] synonym: "negative regulation of IL-26 biosynthesis" EXACT [] synonym: "negative regulation of IL-26 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-26 anabolism" EXACT [] synonym: "negative regulation of interleukin-26 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-26 formation" EXACT [] synonym: "negative regulation of interleukin-26 synthesis" EXACT [] is_a: GO:0032710 ! negative regulation of interleukin-26 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045535 name: negative regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "down regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "downregulation of interleukin-27 biosynthetic process" EXACT [] synonym: "inhibition of interleukin-27 biosynthetic process" NARROW [] synonym: "negative regulation of IL-27 biosynthesis" EXACT [] synonym: "negative regulation of IL-27 biosynthetic process" EXACT [] synonym: "negative regulation of interleukin-27 anabolism" EXACT [] synonym: "negative regulation of interleukin-27 biosynthesis" EXACT [] synonym: "negative regulation of interleukin-27 formation" EXACT [] synonym: "negative regulation of interleukin-27 synthesis" EXACT [] is_a: GO:0032711 ! negative regulation of interleukin-27 production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045536 name: positive regulation of interleukin-24 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] synonym: "activation of interleukin-24 biosynthetic process" NARROW [] synonym: "positive regulation of IL-24 biosynthesis" EXACT [] synonym: "positive regulation of IL-24 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-24 anabolism" EXACT [] synonym: "positive regulation of interleukin-24 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-24 formation" EXACT [] synonym: "positive regulation of interleukin-24 synthesis" EXACT [] synonym: "stimulation of interleukin-24 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-24 biosynthetic process" EXACT [] is_a: GO:0032748 ! positive regulation of interleukin-24 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process [Term] id: GO:0045537 name: positive regulation of interleukin-25 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] synonym: "activation of interleukin-25 biosynthetic process" NARROW [] synonym: "positive regulation of IL-25 biosynthesis" EXACT [] synonym: "positive regulation of IL-25 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-25 anabolism" EXACT [] synonym: "positive regulation of interleukin-25 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-25 formation" EXACT [] synonym: "positive regulation of interleukin-25 synthesis" EXACT [] synonym: "stimulation of interleukin-25 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-25 biosynthetic process" EXACT [] is_a: GO:0032749 ! positive regulation of interleukin-25 production is_a: GO:0045380 ! positive regulation of interleukin-17 biosynthetic process is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process [Term] id: GO:0045538 name: positive regulation of interleukin-26 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] synonym: "activation of interleukin-26 biosynthetic process" NARROW [] synonym: "positive regulation of IL-26 biosynthesis" EXACT [] synonym: "positive regulation of IL-26 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-26 anabolism" EXACT [] synonym: "positive regulation of interleukin-26 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-26 formation" EXACT [] synonym: "positive regulation of interleukin-26 synthesis" EXACT [] synonym: "stimulation of interleukin-26 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-26 biosynthetic process" EXACT [] is_a: GO:0032750 ! positive regulation of interleukin-26 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process [Term] id: GO:0045539 name: positive regulation of interleukin-27 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] synonym: "activation of interleukin-27 biosynthetic process" NARROW [] synonym: "positive regulation of IL-27 biosynthesis" EXACT [] synonym: "positive regulation of IL-27 biosynthetic process" EXACT [] synonym: "positive regulation of interleukin-27 anabolism" EXACT [] synonym: "positive regulation of interleukin-27 biosynthesis" EXACT [] synonym: "positive regulation of interleukin-27 formation" EXACT [] synonym: "positive regulation of interleukin-27 synthesis" EXACT [] synonym: "stimulation of interleukin-27 biosynthetic process" NARROW [] synonym: "up regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT [] synonym: "upregulation of interleukin-27 biosynthetic process" EXACT [] is_a: GO:0032751 ! positive regulation of interleukin-27 production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process [Term] id: GO:0045540 name: regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "regulation of cholesterol anabolism" EXACT [] synonym: "regulation of cholesterol biosynthesis" EXACT [] synonym: "regulation of cholesterol formation" EXACT [] synonym: "regulation of cholesterol synthesis" EXACT [] is_a: GO:0090181 ! regulation of cholesterol metabolic process is_a: GO:0106118 ! regulation of sterol biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006695 ! cholesterol biosynthetic process relationship: regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045541 name: negative regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "down regulation of cholesterol biosynthetic process" EXACT [] synonym: "down-regulation of cholesterol biosynthetic process" EXACT [] synonym: "downregulation of cholesterol biosynthetic process" EXACT [] synonym: "inhibition of cholesterol biosynthetic process" NARROW [] synonym: "negative regulation of cholesterol anabolism" EXACT [] synonym: "negative regulation of cholesterol biosynthesis" EXACT [] synonym: "negative regulation of cholesterol formation" EXACT [] synonym: "negative regulation of cholesterol synthesis" EXACT [] is_a: GO:0045540 ! regulation of cholesterol biosynthetic process is_a: GO:0090206 ! negative regulation of cholesterol metabolic process is_a: GO:0106119 ! negative regulation of sterol biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006695 ! cholesterol biosynthetic process relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045542 name: positive regulation of cholesterol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] synonym: "activation of cholesterol biosynthetic process" NARROW [] synonym: "positive regulation of cholesterol anabolism" EXACT [] synonym: "positive regulation of cholesterol biosynthesis" EXACT [] synonym: "positive regulation of cholesterol formation" EXACT [] synonym: "positive regulation of cholesterol synthesis" EXACT [] synonym: "stimulation of cholesterol biosynthetic process" NARROW [] synonym: "up regulation of cholesterol biosynthetic process" EXACT [] synonym: "up-regulation of cholesterol biosynthetic process" EXACT [] synonym: "upregulation of cholesterol biosynthetic process" EXACT [] is_a: GO:0045540 ! regulation of cholesterol biosynthetic process is_a: GO:0090205 ! positive regulation of cholesterol metabolic process is_a: GO:0106120 ! positive regulation of sterol biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006695 ! cholesterol biosynthetic process relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process [Term] id: GO:0045543 name: gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, GOC:kad] synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" NARROW [EC:1.14.11.13] synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2-oxidase activity" EXACT [] synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13] synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13] xref: EC:1.14.11.13 xref: MetaCyc:PWY-102 xref: RHEA:15005 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0045544 name: gibberellin 20-oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0045545 name: syndecan binding namespace: molecular_function def: "Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, PMID:9355727] is_a: GO:0043394 ! proteoglycan binding [Term] id: GO:0045547 name: dehydrodolichyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0045548 name: phenylalanine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate." [RHEA:21384] synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.24] synonym: "PAL activity" BROAD [EC:4.3.1.24] synonym: "phe ammonia-lyase activity" EXACT [EC:4.3.1.24] synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.24] synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.24] xref: EC:4.3.1.24 xref: EC:4.3.1.25 xref: RHEA:21384 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0045549 name: 9-cis-epoxycarotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51] synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "AtNCED3" RELATED [EC:1.13.11.51] synonym: "NCED" RELATED [EC:1.13.11.51] synonym: "neoxanthin cleavage enzyme" RELATED [] synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51] synonym: "PvNCED1" RELATED [EC:1.13.11.51] synonym: "VP14" RELATED [EC:1.13.11.51] xref: EC:1.13.11.51 is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0045550 name: geranylgeranyl reductase activity namespace: molecular_function def: "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group." [PMID:9492312] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0045551 name: cinnamyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195] synonym: "CAD activity" BROAD [EC:1.1.1.195] synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195] synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195] xref: EC:1.1.1.195 xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:10392 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045552 name: dihydrokaempferol 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219] synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] xref: EC:1.1.1.219 xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN xref: RHEA:23016 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0045553 name: TRAIL biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand). TRAIL induces apoptosis in a wide variety of cells and is a member of the tumor necrosis factor (TNF) family of cytokines." [PMID:9311998] synonym: "TRAIL anabolism" EXACT [] synonym: "TRAIL biosynthesis" EXACT [] synonym: "TRAIL formation" EXACT [] synonym: "TRAIL synthesis" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0032639 ! TRAIL production [Term] id: GO:0045554 name: regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "regulation of TRAIL anabolism" EXACT [] synonym: "regulation of TRAIL biosynthesis" EXACT [] synonym: "regulation of TRAIL formation" EXACT [] synonym: "regulation of TRAIL synthesis" EXACT [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045553 ! TRAIL biosynthetic process relationship: regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045555 name: negative regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "down regulation of TRAIL biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL biosynthetic process" EXACT [] synonym: "downregulation of TRAIL biosynthetic process" EXACT [] synonym: "inhibition of TRAIL biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL anabolism" EXACT [] synonym: "negative regulation of TRAIL biosynthesis" EXACT [] synonym: "negative regulation of TRAIL formation" EXACT [] synonym: "negative regulation of TRAIL synthesis" EXACT [] is_a: GO:0032719 ! negative regulation of TRAIL production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0045554 ! regulation of TRAIL biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045553 ! TRAIL biosynthetic process relationship: negatively_regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045556 name: positive regulation of TRAIL biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] synonym: "activation of TRAIL biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL anabolism" EXACT [] synonym: "positive regulation of TRAIL biosynthesis" EXACT [] synonym: "positive regulation of TRAIL formation" EXACT [] synonym: "positive regulation of TRAIL synthesis" EXACT [] synonym: "stimulation of TRAIL biosynthetic process" NARROW [] synonym: "up regulation of TRAIL biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL biosynthetic process" EXACT [] synonym: "upregulation of TRAIL biosynthetic process" EXACT [] is_a: GO:0032759 ! positive regulation of TRAIL production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0045554 ! regulation of TRAIL biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045553 ! TRAIL biosynthetic process relationship: positively_regulates GO:0045553 ! TRAIL biosynthetic process [Term] id: GO:0045557 name: TRAIL receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "TRAIL receptor anabolism" EXACT [] synonym: "TRAIL receptor biosynthesis" EXACT [] synonym: "TRAIL receptor formation" EXACT [] synonym: "TRAIL receptor synthesis" EXACT [] is_a: GO:0032800 ! receptor biosynthetic process [Term] id: GO:0045558 name: TRAIL receptor 1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998] synonym: "TRAIL receptor 1 anabolism" EXACT [] synonym: "TRAIL receptor 1 biosynthesis" EXACT [] synonym: "TRAIL receptor 1 formation" EXACT [] synonym: "TRAIL receptor 1 synthesis" EXACT [] synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108] is_a: GO:0019538 ! protein metabolic process is_a: GO:0045557 ! TRAIL receptor biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0045559 name: TRAIL receptor 2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998] synonym: "TRAIL receptor 2 anabolism" EXACT [] synonym: "TRAIL receptor 2 biosynthesis" EXACT [] synonym: "TRAIL receptor 2 formation" EXACT [] synonym: "TRAIL receptor 2 synthesis" EXACT [] synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109] is_a: GO:0019538 ! protein metabolic process is_a: GO:0045557 ! TRAIL receptor biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0045560 name: regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "regulation of TRAIL receptor anabolism" EXACT [] synonym: "regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor formation" EXACT [] synonym: "regulation of TRAIL receptor synthesis" EXACT [] is_a: GO:0010869 ! regulation of receptor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045557 ! TRAIL receptor biosynthetic process relationship: regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045561 name: regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor 1 formation" EXACT [] synonym: "regulation of TRAIL receptor 1 synthesis" EXACT [] is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process relationship: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045562 name: regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "regulation of TRAIL receptor 2 formation" EXACT [] synonym: "regulation of TRAIL receptor 2 synthesis" EXACT [] is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process relationship: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045563 name: negative regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor formation" EXACT [] synonym: "negative regulation of TRAIL receptor synthesis" EXACT [] is_a: GO:0010871 ! negative regulation of receptor biosynthetic process is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process relationship: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045564 name: positive regulation of TRAIL receptor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] synonym: "activation of TRAIL receptor biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor formation" EXACT [] synonym: "positive regulation of TRAIL receptor synthesis" EXACT [] synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT [] is_a: GO:0010870 ! positive regulation of receptor biosynthetic process is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process relationship: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process [Term] id: GO:0045565 name: negative regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor 1 formation" EXACT [] synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT [] is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process relationship: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045566 name: positive regulation of TRAIL receptor 1 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor 1 formation" EXACT [] synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT [] synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT [] is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process relationship: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process [Term] id: GO:0045567 name: negative regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "negative regulation of TRAIL receptor 2 formation" EXACT [] synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT [] is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process relationship: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045568 name: positive regulation of TRAIL receptor 2 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT [] synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT [] synonym: "positive regulation of TRAIL receptor 2 formation" EXACT [] synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT [] synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW [] synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT [] is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process relationship: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process [Term] id: GO:0045569 name: TRAIL binding namespace: molecular_function def: "Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] subset: goslim_chembl synonym: "Apo-2L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0045570 name: regulation of imaginal disc growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007446 ! imaginal disc growth relationship: regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045571 name: negative regulation of imaginal disc growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "down regulation of imaginal disc growth" EXACT [] synonym: "down-regulation of imaginal disc growth" EXACT [] synonym: "downregulation of imaginal disc growth" EXACT [] synonym: "inhibition of imaginal disc growth" NARROW [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0046621 ! negative regulation of organ growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007446 ! imaginal disc growth relationship: negatively_regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045572 name: positive regulation of imaginal disc growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] synonym: "activation of imaginal disc growth" NARROW [] synonym: "stimulation of imaginal disc growth" NARROW [] synonym: "up regulation of imaginal disc growth" EXACT [] synonym: "up-regulation of imaginal disc growth" EXACT [] synonym: "upregulation of imaginal disc growth" EXACT [] is_a: GO:0045570 ! regulation of imaginal disc growth is_a: GO:0046622 ! positive regulation of organ growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007446 ! imaginal disc growth relationship: positively_regulates GO:0007446 ! imaginal disc growth [Term] id: GO:0045574 name: sterigmatocystin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators] synonym: "sterigmatocystin breakdown" EXACT [] synonym: "sterigmatocystin catabolism" EXACT [] synonym: "sterigmatocystin degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0045460 ! sterigmatocystin metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process [Term] id: GO:0045575 name: basophil activation namespace: biological_process def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] xref: Wikipedia:Basophil_activation is_a: GO:0036230 ! granulocyte activation [Term] id: GO:0045576 name: mast cell activation namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0045577 name: regulation of B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B cell development" RELATED [GOC:add] synonym: "regulation of B lymphocyte differentiation" EXACT [] synonym: "regulation of B-cell differentiation" EXACT [] synonym: "regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050864 ! regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030183 ! B cell differentiation relationship: regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045578 name: negative regulation of B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B cell differentiation" EXACT [] synonym: "down-regulation of B cell differentiation" EXACT [] synonym: "downregulation of B cell differentiation" EXACT [] synonym: "inhibition of B cell differentiation" NARROW [] synonym: "negative regulation of B cell development" RELATED [GOC:add] synonym: "negative regulation of B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-cell differentiation" EXACT [] synonym: "negative regulation of B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050869 ! negative regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030183 ! B cell differentiation relationship: negatively_regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045579 name: positive regulation of B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B cell differentiation" NARROW [] synonym: "positive regulation of B cell development" RELATED [GOC:add] synonym: "positive regulation of B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-cell differentiation" EXACT [] synonym: "positive regulation of B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B cell differentiation" NARROW [] synonym: "up regulation of B cell differentiation" EXACT [] synonym: "up-regulation of B cell differentiation" EXACT [] synonym: "upregulation of B cell differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050871 ! positive regulation of B cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030183 ! B cell differentiation relationship: positively_regulates GO:0030183 ! B cell differentiation [Term] id: GO:0045580 name: regulation of T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development" RELATED [GOC:add] synonym: "regulation of T lymphocyte differentiation" EXACT [] synonym: "regulation of T-cell differentiation" EXACT [] synonym: "regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030217 ! T cell differentiation relationship: regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045581 name: negative regulation of T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T cell differentiation" EXACT [] synonym: "down-regulation of T cell differentiation" EXACT [] synonym: "downregulation of T cell differentiation" EXACT [] synonym: "inhibition of T cell differentiation" NARROW [] synonym: "negative regulation of T cell development" RELATED [GOC:add] synonym: "negative regulation of T lymphocyte differentiation" EXACT [] synonym: "negative regulation of T-cell differentiation" EXACT [] synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030217 ! T cell differentiation relationship: negatively_regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045582 name: positive regulation of T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T cell differentiation" NARROW [] synonym: "positive regulation of T cell development" RELATED [GOC:add] synonym: "positive regulation of T lymphocyte differentiation" EXACT [] synonym: "positive regulation of T-cell differentiation" EXACT [] synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] synonym: "stimulation of T cell differentiation" NARROW [] synonym: "up regulation of T cell differentiation" EXACT [] synonym: "up-regulation of T cell differentiation" EXACT [] synonym: "upregulation of T cell differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030217 ! T cell differentiation relationship: positively_regulates GO:0030217 ! T cell differentiation [Term] id: GO:0045583 name: regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045065 ! cytotoxic T cell differentiation relationship: regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045584 name: negative regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of cytotoxic T cell differentiation" EXACT [] synonym: "down-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "downregulation of cytotoxic T cell differentiation" EXACT [] synonym: "inhibition of cytotoxic T cell differentiation" NARROW [] synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045585 name: positive regulation of cytotoxic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of cytotoxic T cell differentiation" NARROW [] synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add] synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT [] synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT [] synonym: "stimulation of cytotoxic T cell differentiation" NARROW [] synonym: "up regulation of cytotoxic T cell differentiation" EXACT [] synonym: "up-regulation of cytotoxic T cell differentiation" EXACT [] synonym: "upregulation of cytotoxic T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045065 ! cytotoxic T cell differentiation relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0045586 name: regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046643 ! regulation of gamma-delta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042492 ! gamma-delta T cell differentiation relationship: regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045587 name: negative regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of gamma-delta T cell differentiation" EXACT [] synonym: "down-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "downregulation of gamma-delta T cell differentiation" EXACT [] synonym: "inhibition of gamma-delta T cell differentiation" NARROW [] synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045588 name: positive regulation of gamma-delta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of gamma-delta T cell differentiation" NARROW [] synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add] synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of gamma-delta T cell differentiation" NARROW [] synonym: "up regulation of gamma-delta T cell differentiation" EXACT [] synonym: "up-regulation of gamma-delta T cell differentiation" EXACT [] synonym: "upregulation of gamma-delta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042492 ! gamma-delta T cell differentiation relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0045589 name: regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of regulatory T cell development" RELATED [GOC:add] synonym: "regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of regulatory T-cell differentiation" EXACT [] synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T cell differentiation" EXACT [] synonym: "regulation of suppressor T lymphocyte differentiation" EXACT [] synonym: "regulation of suppressor T-cell differentiation" EXACT [] synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045066 ! regulatory T cell differentiation relationship: regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045590 name: negative regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of regulatory T cell differentiation" EXACT [] synonym: "down-regulation of regulatory T cell differentiation" EXACT [] synonym: "downregulation of regulatory T cell differentiation" EXACT [] synonym: "inhibition of regulatory T cell differentiation" NARROW [] synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of suppressor T cell differentiation" EXACT [] synonym: "negative regulation of suppressor T-cell differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045066 ! regulatory T cell differentiation relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045591 name: positive regulation of regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of regulatory T cell differentiation" NARROW [] synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of suppressor T cell differentiation" EXACT [] synonym: "positive regulation of suppressor T-cell differentiation" EXACT [] synonym: "stimulation of regulatory T cell differentiation" NARROW [] synonym: "up regulation of regulatory T cell differentiation" EXACT [] synonym: "up-regulation of regulatory T cell differentiation" EXACT [] synonym: "upregulation of regulatory T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045066 ! regulatory T cell differentiation relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0045592 name: regulation of cumulus cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000387 ! regulation of antral ovarian follicle growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001549 ! cumulus cell differentiation relationship: regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045593 name: negative regulation of cumulus cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "down regulation of cumulus cell differentiation" EXACT [] synonym: "down-regulation of cumulus cell differentiation" EXACT [] synonym: "downregulation of cumulus cell differentiation" EXACT [] synonym: "inhibition of cumulus cell differentiation" NARROW [] synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1905880 ! negative regulation of oogenesis is_a: GO:2000355 ! negative regulation of ovarian follicle development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001549 ! cumulus cell differentiation relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045594 name: positive regulation of cumulus cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] synonym: "activation of cumulus cell differentiation" NARROW [] synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT [] synonym: "stimulation of cumulus cell differentiation" NARROW [] synonym: "up regulation of cumulus cell differentiation" EXACT [] synonym: "up-regulation of cumulus cell differentiation" EXACT [] synonym: "upregulation of cumulus cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045592 ! regulation of cumulus cell differentiation is_a: GO:1905881 ! positive regulation of oogenesis is_a: GO:2000388 ! positive regulation of antral ovarian follicle growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001549 ! cumulus cell differentiation relationship: positively_regulates GO:0001549 ! cumulus cell differentiation [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030154 ! cell differentiation relationship: regulates GO:0030154 ! cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030154 ! cell differentiation relationship: negatively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030154 ! cell differentiation relationship: positively_regulates GO:0030154 ! cell differentiation [Term] id: GO:0045598 name: regulation of fat cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "regulation of adipocyte cell differentiation" EXACT [] synonym: "regulation of adipocyte differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045444 ! fat cell differentiation relationship: regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045599 name: negative regulation of fat cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "down regulation of fat cell differentiation" EXACT [] synonym: "down-regulation of fat cell differentiation" EXACT [] synonym: "downregulation of fat cell differentiation" EXACT [] synonym: "inhibition of fat cell differentiation" NARROW [] synonym: "negative regulation of adipocyte cell differentiation" EXACT [] synonym: "negative regulation of adipocyte differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045444 ! fat cell differentiation relationship: negatively_regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045600 name: positive regulation of fat cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "activation of fat cell differentiation" NARROW [] synonym: "positive regulation of adipocyte cell differentiation" EXACT [] synonym: "positive regulation of adipocyte differentiation" EXACT [] synonym: "stimulation of fat cell differentiation" NARROW [] synonym: "up regulation of fat cell differentiation" EXACT [] synonym: "up-regulation of fat cell differentiation" EXACT [] synonym: "upregulation of fat cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045444 ! fat cell differentiation relationship: positively_regulates GO:0045444 ! fat cell differentiation [Term] id: GO:0045601 name: regulation of endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045446 ! endothelial cell differentiation relationship: regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045602 name: negative regulation of endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "down regulation of endothelial cell differentiation" EXACT [] synonym: "down-regulation of endothelial cell differentiation" EXACT [] synonym: "downregulation of endothelial cell differentiation" EXACT [] synonym: "inhibition of endothelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045446 ! endothelial cell differentiation relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045603 name: positive regulation of endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "activation of endothelial cell differentiation" NARROW [] synonym: "stimulation of endothelial cell differentiation" NARROW [] synonym: "up regulation of endothelial cell differentiation" EXACT [] synonym: "up-regulation of endothelial cell differentiation" EXACT [] synonym: "upregulation of endothelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045446 ! endothelial cell differentiation relationship: positively_regulates GO:0045446 ! endothelial cell differentiation [Term] id: GO:0045604 name: regulation of epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045682 ! regulation of epidermis development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009913 ! epidermal cell differentiation relationship: regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045605 name: negative regulation of epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "down regulation of epidermal cell differentiation" EXACT [] synonym: "down-regulation of epidermal cell differentiation" EXACT [] synonym: "downregulation of epidermal cell differentiation" EXACT [] synonym: "inhibition of epidermal cell differentiation" NARROW [] synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045683 ! negative regulation of epidermis development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009913 ! epidermal cell differentiation relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045606 name: positive regulation of epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "activation of epidermal cell differentiation" NARROW [] synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermal cell differentiation" NARROW [] synonym: "up regulation of epidermal cell differentiation" EXACT [] synonym: "up-regulation of epidermal cell differentiation" EXACT [] synonym: "upregulation of epidermal cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045684 ! positive regulation of epidermis development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009913 ! epidermal cell differentiation relationship: positively_regulates GO:0009913 ! epidermal cell differentiation [Term] id: GO:0045607 name: regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "regulation of auditory hair cell differentiation" EXACT [] synonym: "regulation of auditory receptor cell differentiation" RELATED [] is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042491 ! inner ear auditory receptor cell differentiation relationship: regulates GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0045608 name: negative regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "down regulation of auditory receptor cell differentiation" EXACT [] synonym: "down-regulation of auditory receptor cell differentiation" EXACT [] synonym: "downregulation of auditory receptor cell differentiation" EXACT [] synonym: "inhibition of auditory receptor cell differentiation" NARROW [] synonym: "negative regulation of auditory hair cell differentiation" EXACT [] synonym: "negative regulation of auditory receptor cell differentiation" RELATED [] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:0045605 ! negative regulation of epidermal cell differentiation is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation is_a: GO:2000981 ! negative regulation of inner ear receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation relationship: negatively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0045609 name: positive regulation of inner ear auditory receptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] synonym: "activation of auditory receptor cell differentiation" NARROW [] synonym: "positive regulation of auditory hair cell differentiation" EXACT [] synonym: "positive regulation of auditory receptor cell differentiation" RELATED [] synonym: "stimulation of auditory receptor cell differentiation" NARROW [] synonym: "up regulation of auditory receptor cell differentiation" EXACT [] synonym: "up-regulation of auditory receptor cell differentiation" EXACT [] synonym: "upregulation of auditory receptor cell differentiation" EXACT [] is_a: GO:0045606 ! positive regulation of epidermal cell differentiation is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation is_a: GO:2000982 ! positive regulation of inner ear receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation relationship: positively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0045610 name: regulation of hemocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042386 ! hemocyte differentiation relationship: regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045611 name: negative regulation of hemocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "down regulation of hemocyte differentiation" EXACT [] synonym: "down-regulation of hemocyte differentiation" EXACT [] synonym: "downregulation of hemocyte differentiation" EXACT [] synonym: "inhibition of hemocyte differentiation" NARROW [] synonym: "negative regulation of arthropod blood cell differentiation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042386 ! hemocyte differentiation relationship: negatively_regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045612 name: positive regulation of hemocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] synonym: "activation of hemocyte differentiation" NARROW [] synonym: "positive regulation of arthropod blood cell differentiation" EXACT [] synonym: "stimulation of hemocyte differentiation" NARROW [] synonym: "up regulation of hemocyte differentiation" EXACT [] synonym: "up-regulation of hemocyte differentiation" EXACT [] synonym: "upregulation of hemocyte differentiation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042386 ! hemocyte differentiation relationship: positively_regulates GO:0042386 ! hemocyte differentiation [Term] id: GO:0045613 name: regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] is_a: GO:0045610 ! regulation of hemocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042387 ! plasmatocyte differentiation relationship: regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045614 name: negative regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "down regulation of plasmatocyte differentiation" EXACT [] synonym: "down-regulation of plasmatocyte differentiation" EXACT [] synonym: "downregulation of plasmatocyte differentiation" EXACT [] synonym: "inhibition of plasmatocyte differentiation" NARROW [] is_a: GO:0045611 ! negative regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042387 ! plasmatocyte differentiation relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045615 name: positive regulation of plasmatocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] synonym: "activation of plasmatocyte differentiation" NARROW [] synonym: "stimulation of plasmatocyte differentiation" NARROW [] synonym: "up regulation of plasmatocyte differentiation" EXACT [] synonym: "up-regulation of plasmatocyte differentiation" EXACT [] synonym: "upregulation of plasmatocyte differentiation" EXACT [] is_a: GO:0045612 ! positive regulation of hemocyte differentiation is_a: GO:0045613 ! regulation of plasmatocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042387 ! plasmatocyte differentiation relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation [Term] id: GO:0045616 name: regulation of keratinocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] is_a: GO:0045604 ! regulation of epidermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030216 ! keratinocyte differentiation relationship: regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045617 name: negative regulation of keratinocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "down regulation of keratinocyte differentiation" EXACT [] synonym: "down-regulation of keratinocyte differentiation" EXACT [] synonym: "downregulation of keratinocyte differentiation" EXACT [] synonym: "inhibition of keratinocyte differentiation" NARROW [] is_a: GO:0045605 ! negative regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030216 ! keratinocyte differentiation relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045618 name: positive regulation of keratinocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] synonym: "activation of keratinocyte differentiation" NARROW [] synonym: "stimulation of keratinocyte differentiation" NARROW [] synonym: "up regulation of keratinocyte differentiation" EXACT [] synonym: "up-regulation of keratinocyte differentiation" EXACT [] synonym: "upregulation of keratinocyte differentiation" EXACT [] is_a: GO:0045606 ! positive regulation of epidermal cell differentiation is_a: GO:0045616 ! regulation of keratinocyte differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030216 ! keratinocyte differentiation relationship: positively_regulates GO:0030216 ! keratinocyte differentiation [Term] id: GO:0045619 name: regulation of lymphocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030098 ! lymphocyte differentiation relationship: regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045620 name: negative regulation of lymphocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of lymphocyte differentiation" EXACT [] synonym: "down-regulation of lymphocyte differentiation" EXACT [] synonym: "downregulation of lymphocyte differentiation" EXACT [] synonym: "inhibition of lymphocyte differentiation" NARROW [] synonym: "negative regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030098 ! lymphocyte differentiation relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of lymphocyte differentiation" NARROW [] synonym: "positive regulation of lymphocyte development" RELATED [GOC:add] synonym: "stimulation of lymphocyte differentiation" NARROW [] synonym: "up regulation of lymphocyte differentiation" EXACT [] synonym: "up-regulation of lymphocyte differentiation" EXACT [] synonym: "upregulation of lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030098 ! lymphocyte differentiation relationship: positively_regulates GO:0030098 ! lymphocyte differentiation [Term] id: GO:0045622 name: regulation of T-helper cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042093 ! T-helper cell differentiation relationship: regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045623 name: negative regulation of T-helper cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper cell differentiation" EXACT [] synonym: "down-regulation of T-helper cell differentiation" EXACT [] synonym: "downregulation of T-helper cell differentiation" EXACT [] synonym: "inhibition of T-helper cell differentiation" NARROW [] synonym: "negative regulation of T-helper cell development" RELATED [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042093 ! T-helper cell differentiation relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045624 name: positive regulation of T-helper cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper cell differentiation" NARROW [] synonym: "positive regulation of T-helper cell development" RELATED [GOC:add] synonym: "stimulation of T-helper cell differentiation" NARROW [] synonym: "up regulation of T-helper cell differentiation" EXACT [] synonym: "up-regulation of T-helper cell differentiation" EXACT [] synonym: "upregulation of T-helper cell differentiation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042093 ! T-helper cell differentiation relationship: positively_regulates GO:0042093 ! T-helper cell differentiation [Term] id: GO:0045625 name: regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0002825 ! regulation of T-helper 1 type immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045063 ! T-helper 1 cell differentiation relationship: regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045626 name: negative regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 1 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "downregulation of T-helper 1 cell differentiation" EXACT [] synonym: "inhibition of T-helper 1 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add] is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045627 name: positive regulation of T-helper 1 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 1 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 1 cell differentiation" NARROW [] synonym: "up regulation of T-helper 1 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 1 cell differentiation" EXACT [] synonym: "upregulation of T-helper 1 cell differentiation" EXACT [] is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045063 ! T-helper 1 cell differentiation relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0045628 name: regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0045622 ! regulation of T-helper cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045064 ! T-helper 2 cell differentiation relationship: regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045629 name: negative regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T-helper 2 cell differentiation" EXACT [] synonym: "down-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "downregulation of T-helper 2 cell differentiation" EXACT [] synonym: "inhibition of T-helper 2 cell differentiation" NARROW [] synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add] is_a: GO:0002829 ! negative regulation of type 2 immune response is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045630 name: positive regulation of T-helper 2 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T-helper 2 cell differentiation" NARROW [] synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add] synonym: "stimulation of T-helper 2 cell differentiation" NARROW [] synonym: "up regulation of T-helper 2 cell differentiation" EXACT [] synonym: "up-regulation of T-helper 2 cell differentiation" EXACT [] synonym: "upregulation of T-helper 2 cell differentiation" EXACT [] is_a: GO:0002830 ! positive regulation of type 2 immune response is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045064 ! T-helper 2 cell differentiation relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0045631 name: regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042490 ! mechanoreceptor differentiation relationship: regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045632 name: negative regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "down regulation of mechanoreceptor differentiation" EXACT [] synonym: "down-regulation of mechanoreceptor differentiation" EXACT [] synonym: "downregulation of mechanoreceptor differentiation" EXACT [] synonym: "inhibition of mechanoreceptor differentiation" NARROW [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045665 ! negative regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042490 ! mechanoreceptor differentiation relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045633 name: positive regulation of mechanoreceptor differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] synonym: "activation of mechanoreceptor differentiation" NARROW [] synonym: "stimulation of mechanoreceptor differentiation" NARROW [] synonym: "up regulation of mechanoreceptor differentiation" EXACT [] synonym: "up-regulation of mechanoreceptor differentiation" EXACT [] synonym: "upregulation of mechanoreceptor differentiation" EXACT [] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation is_a: GO:0045666 ! positive regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042490 ! mechanoreceptor differentiation relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation [Term] id: GO:0045634 name: regulation of melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "regulation of melanophore differentiation" EXACT [] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030318 ! melanocyte differentiation relationship: regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045635 name: negative regulation of melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "down regulation of melanocyte differentiation" EXACT [] synonym: "down-regulation of melanocyte differentiation" EXACT [] synonym: "downregulation of melanocyte differentiation" EXACT [] synonym: "inhibition of melanocyte differentiation" NARROW [] synonym: "negative regulation of melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030318 ! melanocyte differentiation relationship: negatively_regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045636 name: positive regulation of melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] synonym: "activation of melanocyte differentiation" NARROW [] synonym: "positive regulation of melanophore differentiation" EXACT [] synonym: "stimulation of melanocyte differentiation" NARROW [] synonym: "up regulation of melanocyte differentiation" EXACT [] synonym: "up-regulation of melanocyte differentiation" EXACT [] synonym: "upregulation of melanocyte differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030318 ! melanocyte differentiation relationship: positively_regulates GO:0030318 ! melanocyte differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030099 ! myeloid cell differentiation relationship: regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030099 ! myeloid cell differentiation relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030099 ! myeloid cell differentiation relationship: positively_regulates GO:0030099 ! myeloid cell differentiation [Term] id: GO:0045640 name: regulation of basophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030221 ! basophil differentiation relationship: regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045641 name: negative regulation of basophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "down regulation of basophil differentiation" EXACT [] synonym: "down-regulation of basophil differentiation" EXACT [] synonym: "downregulation of basophil differentiation" EXACT [] synonym: "inhibition of basophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030221 ! basophil differentiation relationship: negatively_regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045642 name: positive regulation of basophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators] synonym: "activation of basophil differentiation" NARROW [] synonym: "stimulation of basophil differentiation" NARROW [] synonym: "up regulation of basophil differentiation" EXACT [] synonym: "up-regulation of basophil differentiation" EXACT [] synonym: "upregulation of basophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045640 ! regulation of basophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030221 ! basophil differentiation relationship: positively_regulates GO:0030221 ! basophil differentiation [Term] id: GO:0045643 name: regulation of eosinophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030222 ! eosinophil differentiation relationship: regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045644 name: negative regulation of eosinophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "down regulation of eosinophil differentiation" EXACT [] synonym: "down-regulation of eosinophil differentiation" EXACT [] synonym: "downregulation of eosinophil differentiation" EXACT [] synonym: "inhibition of eosinophil differentiation" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030222 ! eosinophil differentiation relationship: negatively_regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045645 name: positive regulation of eosinophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] synonym: "activation of eosinophil differentiation" NARROW [] synonym: "stimulation of eosinophil differentiation" NARROW [] synonym: "up regulation of eosinophil differentiation" EXACT [] synonym: "up-regulation of eosinophil differentiation" EXACT [] synonym: "upregulation of eosinophil differentiation" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045643 ! regulation of eosinophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030222 ! eosinophil differentiation relationship: positively_regulates GO:0030222 ! eosinophil differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030218 ! erythrocyte differentiation relationship: regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030218 ! erythrocyte differentiation relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030218 ! erythrocyte differentiation relationship: positively_regulates GO:0030218 ! erythrocyte differentiation [Term] id: GO:0045649 name: regulation of macrophage differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030225 ! macrophage differentiation relationship: regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045650 name: negative regulation of macrophage differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "down regulation of macrophage differentiation" EXACT [] synonym: "down-regulation of macrophage differentiation" EXACT [] synonym: "downregulation of macrophage differentiation" EXACT [] synonym: "inhibition of macrophage differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030225 ! macrophage differentiation relationship: negatively_regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045651 name: positive regulation of macrophage differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "activation of macrophage differentiation" NARROW [] synonym: "stimulation of macrophage differentiation" NARROW [] synonym: "up regulation of macrophage differentiation" EXACT [] synonym: "up-regulation of macrophage differentiation" EXACT [] synonym: "upregulation of macrophage differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030225 ! macrophage differentiation relationship: positively_regulates GO:0030225 ! macrophage differentiation [Term] id: GO:0045652 name: regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030219 ! megakaryocyte differentiation relationship: regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045653 name: negative regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "down regulation of megakaryocyte differentiation" EXACT [] synonym: "down-regulation of megakaryocyte differentiation" EXACT [] synonym: "downregulation of megakaryocyte differentiation" EXACT [] synonym: "inhibition of megakaryocyte differentiation" NARROW [] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030219 ! megakaryocyte differentiation relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045654 name: positive regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "activation of megakaryocyte differentiation" NARROW [] synonym: "stimulation of megakaryocyte differentiation" NARROW [] synonym: "up regulation of megakaryocyte differentiation" EXACT [] synonym: "up-regulation of megakaryocyte differentiation" EXACT [] synonym: "upregulation of megakaryocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030219 ! megakaryocyte differentiation relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation [Term] id: GO:0045655 name: regulation of monocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030224 ! monocyte differentiation relationship: regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045656 name: negative regulation of monocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "down regulation of monocyte differentiation" EXACT [] synonym: "down-regulation of monocyte differentiation" EXACT [] synonym: "downregulation of monocyte differentiation" EXACT [] synonym: "inhibition of monocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030224 ! monocyte differentiation relationship: negatively_regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045657 name: positive regulation of monocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "activation of monocyte differentiation" NARROW [] synonym: "stimulation of monocyte differentiation" NARROW [] synonym: "up regulation of monocyte differentiation" EXACT [] synonym: "up-regulation of monocyte differentiation" EXACT [] synonym: "upregulation of monocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030224 ! monocyte differentiation relationship: positively_regulates GO:0030224 ! monocyte differentiation [Term] id: GO:0045658 name: regulation of neutrophil differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030223 ! neutrophil differentiation relationship: regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045659 name: negative regulation of neutrophil differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "down regulation of neutrophil differentiation" EXACT [] synonym: "down-regulation of neutrophil differentiation" EXACT [] synonym: "downregulation of neutrophil differentiation" EXACT [] synonym: "inhibition of neutrophil differentiation" NARROW [] is_a: GO:0030853 ! negative regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030223 ! neutrophil differentiation relationship: negatively_regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045660 name: positive regulation of neutrophil differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] synonym: "activation of neutrophil differentiation" NARROW [] synonym: "stimulation of neutrophil differentiation" NARROW [] synonym: "up regulation of neutrophil differentiation" EXACT [] synonym: "up-regulation of neutrophil differentiation" EXACT [] synonym: "upregulation of neutrophil differentiation" EXACT [] is_a: GO:0030854 ! positive regulation of granulocyte differentiation is_a: GO:0045658 ! regulation of neutrophil differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030223 ! neutrophil differentiation relationship: positively_regulates GO:0030223 ! neutrophil differentiation [Term] id: GO:0045661 name: regulation of myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045445 ! myoblast differentiation relationship: regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045662 name: negative regulation of myoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "down regulation of myoblast differentiation" EXACT [] synonym: "down-regulation of myoblast differentiation" EXACT [] synonym: "downregulation of myoblast differentiation" EXACT [] synonym: "inhibition of myoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045445 ! myoblast differentiation relationship: negatively_regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045663 name: positive regulation of myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "activation of myoblast differentiation" NARROW [] synonym: "stimulation of myoblast differentiation" NARROW [] synonym: "up regulation of myoblast differentiation" EXACT [] synonym: "up-regulation of myoblast differentiation" EXACT [] synonym: "upregulation of myoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045445 ! myoblast differentiation relationship: positively_regulates GO:0045445 ! myoblast differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030182 ! neuron differentiation relationship: regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030182 ! neuron differentiation relationship: negatively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030182 ! neuron differentiation relationship: positively_regulates GO:0030182 ! neuron differentiation [Term] id: GO:0045667 name: regulation of osteoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001649 ! osteoblast differentiation relationship: regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045668 name: negative regulation of osteoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "down regulation of osteoblast differentiation" EXACT [] synonym: "down-regulation of osteoblast differentiation" EXACT [] synonym: "downregulation of osteoblast differentiation" EXACT [] synonym: "inhibition of osteoblast differentiation" NARROW [] is_a: GO:0030279 ! negative regulation of ossification is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001649 ! osteoblast differentiation relationship: negatively_regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045669 name: positive regulation of osteoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] synonym: "activation of osteoblast differentiation" NARROW [] synonym: "stimulation of osteoblast differentiation" NARROW [] synonym: "up regulation of osteoblast differentiation" EXACT [] synonym: "up-regulation of osteoblast differentiation" EXACT [] synonym: "upregulation of osteoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045667 ! regulation of osteoblast differentiation is_a: GO:0045778 ! positive regulation of ossification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001649 ! osteoblast differentiation relationship: positively_regulates GO:0001649 ! osteoblast differentiation [Term] id: GO:0045670 name: regulation of osteoclast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030316 ! osteoclast differentiation relationship: regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045671 name: negative regulation of osteoclast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "down regulation of osteoclast differentiation" EXACT [] synonym: "down-regulation of osteoclast differentiation" EXACT [] synonym: "downregulation of osteoclast differentiation" EXACT [] synonym: "inhibition of osteoclast differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030316 ! osteoclast differentiation relationship: negatively_regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045672 name: positive regulation of osteoclast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "activation of osteoclast differentiation" NARROW [] synonym: "stimulation of osteoclast differentiation" NARROW [] synonym: "up regulation of osteoclast differentiation" EXACT [] synonym: "up-regulation of osteoclast differentiation" EXACT [] synonym: "upregulation of osteoclast differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030316 ! osteoclast differentiation relationship: positively_regulates GO:0030316 ! osteoclast differentiation [Term] id: GO:0045676 name: regulation of R7 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045466 ! R7 cell differentiation relationship: regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045677 name: negative regulation of R7 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R7 differentiation" EXACT [] synonym: "down-regulation of R7 differentiation" EXACT [] synonym: "downregulation of R7 differentiation" EXACT [] synonym: "inhibition of R7 differentiation" NARROW [] synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045466 ! R7 cell differentiation relationship: negatively_regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045678 name: positive regulation of R7 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R7 differentiation" NARROW [] synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R7 differentiation" NARROW [] synonym: "up regulation of R7 differentiation" EXACT [] synonym: "up-regulation of R7 differentiation" EXACT [] synonym: "upregulation of R7 differentiation" EXACT [] is_a: GO:0045676 ! regulation of R7 cell differentiation is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045466 ! R7 cell differentiation relationship: positively_regulates GO:0045466 ! R7 cell differentiation [Term] id: GO:0045679 name: regulation of R8 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators] is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045465 ! R8 cell differentiation relationship: regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045680 name: negative regulation of R8 cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of R8 differentiation" EXACT [] synonym: "down-regulation of R8 differentiation" EXACT [] synonym: "downregulation of R8 differentiation" EXACT [] synonym: "inhibition of R8 differentiation" NARROW [] synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045465 ! R8 cell differentiation relationship: negatively_regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045681 name: positive regulation of R8 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R8 differentiation" NARROW [] synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R8 differentiation" NARROW [] synonym: "up regulation of R8 differentiation" EXACT [] synonym: "up-regulation of R8 differentiation" EXACT [] synonym: "upregulation of R8 differentiation" EXACT [] is_a: GO:0045679 ! regulation of R8 cell differentiation is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045465 ! R8 cell differentiation relationship: positively_regulates GO:0045465 ! R8 cell differentiation [Term] id: GO:0045682 name: regulation of epidermis development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "regulation of epidermal development" EXACT [] synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008544 ! epidermis development relationship: regulates GO:0008544 ! epidermis development [Term] id: GO:0045683 name: negative regulation of epidermis development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "down regulation of epidermis development" EXACT [] synonym: "down-regulation of epidermis development" EXACT [] synonym: "downregulation of epidermis development" EXACT [] synonym: "inhibition of epidermis development" NARROW [] synonym: "negative regulation of epidermal development" EXACT [] synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008544 ! epidermis development relationship: negatively_regulates GO:0008544 ! epidermis development [Term] id: GO:0045684 name: positive regulation of epidermis development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "activation of epidermis development" NARROW [] synonym: "positive regulation of epidermal development" EXACT [] synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermis development" NARROW [] synonym: "up regulation of epidermis development" EXACT [] synonym: "up-regulation of epidermis development" EXACT [] synonym: "upregulation of epidermis development" EXACT [] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008544 ! epidermis development relationship: positively_regulates GO:0008544 ! epidermis development [Term] id: GO:0045685 name: regulation of glial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "regulation of glia cell differentiation" EXACT [] synonym: "regulation of neuroglia differentiation" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010001 ! glial cell differentiation relationship: regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045686 name: negative regulation of glial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "down regulation of glial cell differentiation" EXACT [] synonym: "down-regulation of glial cell differentiation" EXACT [] synonym: "downregulation of glial cell differentiation" EXACT [] synonym: "inhibition of glial cell differentiation" NARROW [] synonym: "negative regulation of glia cell differentiation" EXACT [] synonym: "negative regulation of neuroglia differentiation" EXACT [] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010001 ! glial cell differentiation relationship: negatively_regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045687 name: positive regulation of glial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "activation of glial cell differentiation" NARROW [] synonym: "positive regulation of glia cell differentiation" EXACT [] synonym: "positive regulation of neuroglia differentiation" EXACT [] synonym: "stimulation of glial cell differentiation" NARROW [] synonym: "up regulation of glial cell differentiation" EXACT [] synonym: "up-regulation of glial cell differentiation" EXACT [] synonym: "upregulation of glial cell differentiation" EXACT [] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010001 ! glial cell differentiation relationship: positively_regulates GO:0010001 ! glial cell differentiation [Term] id: GO:0045688 name: regulation of antipodal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009557 ! antipodal cell differentiation relationship: regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045689 name: negative regulation of antipodal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of antipodal cell differentiation" EXACT [] synonym: "down-regulation of antipodal cell differentiation" EXACT [] synonym: "downregulation of antipodal cell differentiation" EXACT [] synonym: "inhibition of antipodal cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045688 ! regulation of antipodal cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009557 ! antipodal cell differentiation relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045690 name: positive regulation of antipodal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of antipodal cell differentiation" NARROW [] synonym: "stimulation of antipodal cell differentiation" NARROW [] synonym: "up regulation of antipodal cell differentiation" EXACT [] synonym: "up-regulation of antipodal cell differentiation" EXACT [] synonym: "upregulation of antipodal cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045688 ! regulation of antipodal cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009557 ! antipodal cell differentiation relationship: positively_regulates GO:0009557 ! antipodal cell differentiation [Term] id: GO:0045691 name: regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "regulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009559 ! embryo sac central cell differentiation relationship: regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045692 name: negative regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of female gametophyte central cell differentiation" EXACT [] synonym: "down-regulation of female gametophyte central cell differentiation" EXACT [] synonym: "downregulation of female gametophyte central cell differentiation" EXACT [] synonym: "inhibition of female gametophyte central cell differentiation" NARROW [] synonym: "negative regulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045691 ! regulation of embryo sac central cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009559 ! embryo sac central cell differentiation relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045693 name: positive regulation of embryo sac central cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of female gametophyte central cell differentiation" NARROW [] synonym: "positive regulation of female gametophyte central cell differentiation" EXACT [] synonym: "stimulation of female gametophyte central cell differentiation" NARROW [] synonym: "up regulation of female gametophyte central cell differentiation" EXACT [] synonym: "up-regulation of female gametophyte central cell differentiation" EXACT [] synonym: "upregulation of female gametophyte central cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045691 ! regulation of embryo sac central cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009559 ! embryo sac central cell differentiation relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0045694 name: regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "regulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009560 ! embryo sac egg cell differentiation relationship: regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045695 name: negative regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "down regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "downregulation of female gametophyte egg cell differentiation" EXACT [] synonym: "inhibition of female gametophyte egg cell differentiation" NARROW [] synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045696 name: positive regulation of embryo sac egg cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] synonym: "activation of female gametophyte egg cell differentiation" NARROW [] synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "stimulation of female gametophyte egg cell differentiation" NARROW [] synonym: "up regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT [] synonym: "upregulation of female gametophyte egg cell differentiation" EXACT [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009560 ! embryo sac egg cell differentiation relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation [Term] id: GO:0045697 name: regulation of synergid differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "regulation of synergid cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009563 ! synergid differentiation relationship: regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045698 name: negative regulation of synergid differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "down regulation of synergid differentiation" EXACT [] synonym: "down-regulation of synergid differentiation" EXACT [] synonym: "downregulation of synergid differentiation" EXACT [] synonym: "inhibition of synergid differentiation" NARROW [] synonym: "negative regulation of synergid cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045697 ! regulation of synergid differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009563 ! synergid differentiation relationship: negatively_regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045699 name: positive regulation of synergid differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] synonym: "activation of synergid differentiation" NARROW [] synonym: "positive regulation of synergid cell differentiation" EXACT [] synonym: "stimulation of synergid differentiation" NARROW [] synonym: "up regulation of synergid differentiation" EXACT [] synonym: "up-regulation of synergid differentiation" EXACT [] synonym: "upregulation of synergid differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045697 ! regulation of synergid differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009563 ! synergid differentiation relationship: positively_regulates GO:0009563 ! synergid differentiation [Term] id: GO:0045700 name: regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:1903353 ! regulation of nucleus organization is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007289 ! spermatid nucleus differentiation relationship: regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045701 name: negative regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "down regulation of spermatid nuclear differentiation" EXACT [] synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] synonym: "downregulation of spermatid nuclear differentiation" EXACT [] synonym: "inhibition of spermatid nuclear differentiation" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007289 ! spermatid nucleus differentiation relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045702 name: positive regulation of spermatid nuclear differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] synonym: "activation of spermatid nuclear differentiation" NARROW [] synonym: "stimulation of spermatid nuclear differentiation" NARROW [] synonym: "up regulation of spermatid nuclear differentiation" EXACT [] synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] synonym: "upregulation of spermatid nuclear differentiation" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045700 ! regulation of spermatid nuclear differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007289 ! spermatid nucleus differentiation relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0045703 name: ketoreductase activity namespace: molecular_function def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [GOC:curators] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0045704 name: regulation of salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "regulation of salivary gland determination" EXACT [GOC:tb] is_a: GO:0003156 ! regulation of animal organ formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007432 ! salivary gland boundary specification relationship: regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045705 name: negative regulation of salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "down regulation of salivary gland determination" EXACT [] synonym: "down-regulation of salivary gland determination" EXACT [] synonym: "downregulation of salivary gland determination" EXACT [] synonym: "inhibition of salivary gland determination" NARROW [] synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007432 ! salivary gland boundary specification relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045706 name: positive regulation of salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] synonym: "activation of salivary gland determination" NARROW [] synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of salivary gland determination" NARROW [] synonym: "up regulation of salivary gland determination" EXACT [] synonym: "up-regulation of salivary gland determination" EXACT [] synonym: "upregulation of salivary gland determination" EXACT [] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007432 ! salivary gland boundary specification relationship: positively_regulates GO:0007432 ! salivary gland boundary specification [Term] id: GO:0045707 name: regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007434 ! adult salivary gland boundary specification relationship: regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045708 name: regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb] is_a: GO:0045704 ! regulation of salivary gland boundary specification is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007433 ! larval salivary gland boundary specification relationship: regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045709 name: negative regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "down regulation of adult salivary gland determination" EXACT [] synonym: "down-regulation of adult salivary gland determination" EXACT [] synonym: "downregulation of adult salivary gland determination" EXACT [] synonym: "inhibition of adult salivary gland determination" NARROW [] synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb] is_a: GO:0045705 ! negative regulation of salivary gland boundary specification is_a: GO:0045707 ! regulation of adult salivary gland boundary specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007434 ! adult salivary gland boundary specification relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045710 name: negative regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "down regulation of larval salivary gland determination" EXACT [] synonym: "down-regulation of larval salivary gland determination" EXACT [] synonym: "downregulation of larval salivary gland determination" EXACT [] synonym: "inhibition of larval salivary gland determination" NARROW [] synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb] is_a: GO:0045705 ! negative regulation of salivary gland boundary specification is_a: GO:0045708 ! regulation of larval salivary gland boundary specification is_a: GO:0048581 ! negative regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007433 ! larval salivary gland boundary specification relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045711 name: positive regulation of adult salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] synonym: "activation of adult salivary gland determination" NARROW [] synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of adult salivary gland determination" NARROW [] synonym: "up regulation of adult salivary gland determination" EXACT [] synonym: "up-regulation of adult salivary gland determination" EXACT [] synonym: "upregulation of adult salivary gland determination" EXACT [] is_a: GO:0045706 ! positive regulation of salivary gland boundary specification is_a: GO:0045707 ! regulation of adult salivary gland boundary specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007434 ! adult salivary gland boundary specification relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification [Term] id: GO:0045712 name: positive regulation of larval salivary gland boundary specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] synonym: "activation of larval salivary gland determination" NARROW [] synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb] synonym: "stimulation of larval salivary gland determination" NARROW [] synonym: "up regulation of larval salivary gland determination" EXACT [] synonym: "up-regulation of larval salivary gland determination" EXACT [] synonym: "upregulation of larval salivary gland determination" EXACT [] is_a: GO:0045706 ! positive regulation of salivary gland boundary specification is_a: GO:0045708 ! regulation of larval salivary gland boundary specification is_a: GO:0048582 ! positive regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007433 ! larval salivary gland boundary specification relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification [Term] id: GO:0045713 name: low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells." [GOC:go_curators] synonym: "LDLr biosynthesis" EXACT [] synonym: "LDLr biosynthetic process" EXACT [] synonym: "low-density lipoprotein receptor anabolism" EXACT [] synonym: "low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "low-density lipoprotein receptor formation" EXACT [] synonym: "low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process is_a: GO:0032800 ! receptor biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0045714 name: regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] synonym: "regulation of LDLr biosynthesis" EXACT [] synonym: "regulation of LDLr biosynthetic process" EXACT [] synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process relationship: regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045715 name: negative regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT [] is_a: GO:0010871 ! negative regulation of receptor biosynthetic process is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process relationship: negatively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045716 name: positive regulation of low-density lipoprotein particle receptor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT [] synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW [] synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] is_a: GO:0010870 ! positive regulation of receptor biosynthetic process is_a: GO:0045714 ! regulation of low-density lipoprotein particle receptor biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process relationship: positively_regulates GO:0045713 ! low-density lipoprotein particle receptor biosynthetic process [Term] id: GO:0045717 name: negative regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] synonym: "down regulation of fatty acid biosynthetic process" EXACT [] synonym: "down-regulation of fatty acid biosynthetic process" EXACT [] synonym: "downregulation of fatty acid biosynthetic process" EXACT [] synonym: "inhibition of fatty acid biosynthetic process" NARROW [] synonym: "negative regulation of fatty acid anabolism" EXACT [] synonym: "negative regulation of fatty acid biosynthesis" EXACT [] synonym: "negative regulation of fatty acid formation" EXACT [] synonym: "negative regulation of fatty acid synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006633 ! fatty acid biosynthetic process relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0045718 name: obsolete negative regulation of flagellum assembly namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "down regulation of flagellum assembly" EXACT [] synonym: "down-regulation of flagellum assembly" EXACT [] synonym: "downregulation of flagellum assembly" EXACT [] synonym: "inhibition of flagellum assembly" NARROW [] synonym: "negative regulation of flagella assembly" EXACT [] synonym: "negative regulation of flagellum assembly" EXACT [] synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah] is_obsolete: true consider: GO:1902018 [Term] id: GO:0045719 name: negative regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen biosynthetic process" EXACT [] synonym: "down-regulation of glycogen biosynthetic process" EXACT [] synonym: "downregulation of glycogen biosynthetic process" EXACT [] synonym: "inhibition of glycogen biosynthetic process" NARROW [] synonym: "negative regulation of glycogen anabolism" EXACT [] synonym: "negative regulation of glycogen biosynthesis" EXACT [] synonym: "negative regulation of glycogen formation" EXACT [] synonym: "negative regulation of glycogen synthesis" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005978 ! glycogen biosynthetic process relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0045720 name: negative regulation of integrin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "down regulation of integrin biosynthetic process" EXACT [] synonym: "down-regulation of integrin biosynthetic process" EXACT [] synonym: "downregulation of integrin biosynthetic process" EXACT [] synonym: "inhibition of integrin biosynthetic process" NARROW [] synonym: "negative regulation of integrin anabolism" EXACT [] synonym: "negative regulation of integrin biosynthesis" EXACT [] synonym: "negative regulation of integrin formation" EXACT [] synonym: "negative regulation of integrin synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045113 ! regulation of integrin biosynthetic process is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045112 ! integrin biosynthetic process relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045721 name: negative regulation of gluconeogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "down regulation of gluconeogenesis" EXACT [] synonym: "down-regulation of gluconeogenesis" EXACT [] synonym: "downregulation of gluconeogenesis" EXACT [] synonym: "inhibition of gluconeogenesis" NARROW [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006094 ! gluconeogenesis relationship: negatively_regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0045722 name: positive regulation of gluconeogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] synonym: "activation of gluconeogenesis" NARROW [] synonym: "stimulation of gluconeogenesis" NARROW [] synonym: "up regulation of gluconeogenesis" EXACT [] synonym: "up-regulation of gluconeogenesis" EXACT [] synonym: "upregulation of gluconeogenesis" EXACT [] is_a: GO:0006111 ! regulation of gluconeogenesis is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006094 ! gluconeogenesis relationship: positively_regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0045723 name: positive regulation of fatty acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] synonym: "activation of fatty acid biosynthetic process" NARROW [] synonym: "positive regulation of fatty acid anabolism" EXACT [] synonym: "positive regulation of fatty acid biosynthesis" EXACT [] synonym: "positive regulation of fatty acid formation" EXACT [] synonym: "positive regulation of fatty acid synthesis" EXACT [] synonym: "stimulation of fatty acid biosynthetic process" NARROW [] synonym: "up regulation of fatty acid biosynthetic process" EXACT [] synonym: "up-regulation of fatty acid biosynthetic process" EXACT [] synonym: "upregulation of fatty acid biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006633 ! fatty acid biosynthetic process relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060271 ! cilium assembly relationship: positively_regulates GO:0060271 ! cilium assembly [Term] id: GO:0045725 name: positive regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "activation of glycogen biosynthetic process" NARROW [] synonym: "positive regulation of glycogen anabolism" EXACT [] synonym: "positive regulation of glycogen biosynthesis" EXACT [] synonym: "positive regulation of glycogen formation" EXACT [] synonym: "positive regulation of glycogen synthesis" EXACT [] synonym: "stimulation of glycogen biosynthetic process" NARROW [] synonym: "up regulation of glycogen biosynthetic process" EXACT [] synonym: "up-regulation of glycogen biosynthetic process" EXACT [] synonym: "upregulation of glycogen biosynthetic process" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005978 ! glycogen biosynthetic process relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0045726 name: positive regulation of integrin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] synonym: "activation of integrin biosynthetic process" NARROW [] synonym: "positive regulation of integrin anabolism" EXACT [] synonym: "positive regulation of integrin biosynthesis" EXACT [] synonym: "positive regulation of integrin formation" EXACT [] synonym: "positive regulation of integrin synthesis" EXACT [] synonym: "stimulation of integrin biosynthetic process" NARROW [] synonym: "up regulation of integrin biosynthetic process" EXACT [] synonym: "up-regulation of integrin biosynthetic process" EXACT [] synonym: "upregulation of integrin biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045113 ! regulation of integrin biosynthetic process is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045112 ! integrin biosynthetic process relationship: positively_regulates GO:0045112 ! integrin biosynthetic process [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process alt_id: GO:0045946 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006412 ! translation relationship: positively_regulates GO:0006412 ! translation [Term] id: GO:0045728 name: respiratory burst after phagocytosis namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [GOC:curators, ISBN:0198506732] synonym: "metabolic burst after phagocytosis" EXACT [] synonym: "oxidative burst after phagocytosis" EXACT [] is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0045729 name: respiratory burst at fertilization namespace: biological_process def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732, PMID:2537493, PMID:9013127] synonym: "metabolic burst at fertilization" EXACT [] synonym: "oxidative burst at fertilization" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: part_of GO:0009566 ! fertilization relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0045730 name: respiratory burst namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732] synonym: "metabolic burst" EXACT [] synonym: "oxidative burst" EXACT [] xref: Wikipedia:Respiratory_burst is_a: GO:0008152 ! metabolic process [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030163 ! protein catabolic process relationship: positively_regulates GO:0030163 ! protein catabolic process [Term] id: GO:0045733 name: acetate catabolic process namespace: biological_process alt_id: GO:0019663 def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate breakdown" EXACT [] synonym: "acetate catabolism" EXACT [] synonym: "acetate degradation" EXACT [] synonym: "homoacetate catabolic process" RELATED [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0045734 name: regulation of acetate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "regulation of acetate breakdown" EXACT [] synonym: "regulation of acetate catabolism" EXACT [] synonym: "regulation of acetate degradation" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045733 ! acetate catabolic process relationship: regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045735 name: nutrient reservoir activity namespace: molecular_function def: "Functions in the storage of nutritious substrates." [GOC:ai] comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. subset: goslim_pir synonym: "storage protein" RELATED [] synonym: "storage protein of fat body" RELATED [] synonym: "yolk protein" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0045736 name: negative regulation of cyclin-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity is_a: GO:1904030 ! negative regulation of cyclin-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity relationship: negatively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0045737 name: positive regulation of cyclin-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr] synonym: "activation of cyclin-dependent protein kinase activity" BROAD [] synonym: "positive regulation of CDK activity" BROAD [] synonym: "positive regulation of cyclin-dependent protein kinase activity" BROAD [GOC:pr] synonym: "stimulation of cyclin-dependent protein kinase activity" BROAD [] synonym: "up regulation of cyclin-dependent protein kinase activity" BROAD [] synonym: "up-regulation of cyclin-dependent protein kinase activity" BROAD [] synonym: "upregulation of cyclin-dependent protein kinase activity" BROAD [] is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity is_a: GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity relationship: positively_regulates GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0045738 name: negative regulation of DNA repair namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators] synonym: "down regulation of DNA repair" EXACT [] synonym: "down-regulation of DNA repair" EXACT [] synonym: "downregulation of DNA repair" EXACT [] synonym: "inhibition of DNA repair" NARROW [] is_a: GO:0006282 ! regulation of DNA repair is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006281 ! DNA repair relationship: negatively_regulates GO:0006281 ! DNA repair [Term] id: GO:0045739 name: positive regulation of DNA repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] synonym: "activation of DNA repair" NARROW [] synonym: "stimulation of DNA repair" NARROW [] synonym: "up regulation of DNA repair" EXACT [] synonym: "up-regulation of DNA repair" EXACT [] synonym: "upregulation of DNA repair" EXACT [] is_a: GO:0006282 ! regulation of DNA repair is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006281 ! DNA repair relationship: positively_regulates GO:0006281 ! DNA repair [Term] id: GO:0045740 name: positive regulation of DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] synonym: "activation of DNA replication" NARROW [] synonym: "stimulation of DNA replication" NARROW [] synonym: "up regulation of DNA replication" EXACT [] synonym: "up-regulation of DNA replication" EXACT [] synonym: "upregulation of DNA replication" EXACT [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006260 ! DNA replication relationship: positively_regulates GO:0006260 ! DNA replication [Term] id: GO:0045741 name: positive regulation of epidermal growth factor-activated receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] synonym: "activation of epidermal growth factor receptor activity" NARROW [] synonym: "positive regulation of EGF receptor activity" EXACT [] synonym: "positive regulation of EGFR activity" EXACT [] synonym: "positive regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "stimulation of epidermal growth factor receptor activity" NARROW [] synonym: "up regulation of epidermal growth factor receptor activity" EXACT [] synonym: "up-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "upregulation of epidermal growth factor receptor activity" EXACT [] is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity relationship: positively_regulates GO:0005006 ! epidermal growth factor-activated receptor activity [Term] id: GO:0045742 name: positive regulation of epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of EGF receptor signaling pathway" EXACT [] synonym: "positive regulation of EGF receptor signalling pathway" EXACT [] synonym: "positive regulation of EGFR signaling pathway" EXACT [] synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT [] is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:1901186 ! positive regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0045743 name: positive regulation of fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of FGF receptor signaling pathway" EXACT [] synonym: "positive regulation of FGF receptor signalling pathway" EXACT [] synonym: "positive regulation of FGFR signaling pathway" EXACT [] synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0045744 name: negative regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0045745 name: positive regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0045746 name: negative regulation of Notch signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "down regulation of Notch signaling pathway" EXACT [] synonym: "down-regulation of Notch signaling pathway" EXACT [] synonym: "downregulation of Notch signaling pathway" EXACT [] synonym: "inhibition of Notch signaling pathway" NARROW [] synonym: "negative regulation of N signaling pathway" EXACT [] synonym: "negative regulation of N signalling pathway" EXACT [] synonym: "negative regulation of Notch signalling pathway" EXACT [] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007219 ! Notch signaling pathway relationship: negatively_regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0045747 name: positive regulation of Notch signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "activation of Notch signaling pathway" NARROW [] synonym: "positive regulation of N signaling pathway" EXACT [] synonym: "positive regulation of N signalling pathway" EXACT [] synonym: "positive regulation of Notch signalling pathway" EXACT [] synonym: "stimulation of Notch signaling pathway" NARROW [] synonym: "up regulation of Notch signaling pathway" EXACT [] synonym: "up-regulation of Notch signaling pathway" EXACT [] synonym: "upregulation of Notch signaling pathway" EXACT [] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007219 ! Notch signaling pathway relationship: positively_regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0045748 name: positive regulation of R8 cell spacing in compound eye namespace: biological_process def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of R8 spacing" NARROW [] synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of R8 spacing" NARROW [] synonym: "up regulation of R8 spacing" EXACT [] synonym: "up-regulation of R8 spacing" EXACT [] synonym: "upregulation of R8 spacing" EXACT [] is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye [Term] id: GO:0045749 name: obsolete negative regulation of S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "down regulation of S phase of mitotic cell cycle" EXACT [] synonym: "down-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "downregulation of S phase of mitotic cell cycle" EXACT [] synonym: "inhibition of S phase of mitotic cell cycle" NARROW [] synonym: "negative regulation of S phase of mitotic cell cycle" EXACT [] synonym: "negative regulation of S-phase of mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0045750 name: obsolete positive regulation of S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "activation of S phase of mitotic cell cycle" NARROW [] synonym: "positive regulation of S phase of mitotic cell cycle" EXACT [] synonym: "positive regulation of S-phase of mitotic cell cycle" EXACT [] synonym: "stimulation of S phase of mitotic cell cycle" NARROW [] synonym: "up regulation of S phase of mitotic cell cycle" EXACT [] synonym: "up-regulation of S phase of mitotic cell cycle" EXACT [] synonym: "upregulation of S phase of mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0045751 name: negative regulation of Toll signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "down regulation of Toll signaling pathway" EXACT [] synonym: "down-regulation of Toll signaling pathway" EXACT [] synonym: "downregulation of Toll signaling pathway" EXACT [] synonym: "inhibition of Toll signaling pathway" NARROW [] synonym: "negative regulation of Tl signaling pathway" EXACT [] synonym: "negative regulation of Tl signalling pathway" EXACT [] is_a: GO:0008592 ! regulation of Toll signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008063 ! Toll signaling pathway relationship: negatively_regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0045752 name: positive regulation of Toll signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "activation of Toll signaling pathway" NARROW [] synonym: "positive regulation of Tl signaling pathway" EXACT [] synonym: "positive regulation of Tl signalling pathway" EXACT [] synonym: "stimulation of Toll signaling pathway" NARROW [] synonym: "up regulation of Toll signaling pathway" EXACT [] synonym: "up-regulation of Toll signaling pathway" EXACT [] synonym: "upregulation of Toll signaling pathway" EXACT [] is_a: GO:0008592 ! regulation of Toll signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008063 ! Toll signaling pathway relationship: positively_regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0045753 name: negative regulation of acetate catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "down regulation of acetate catabolic process" EXACT [] synonym: "down-regulation of acetate catabolic process" EXACT [] synonym: "downregulation of acetate catabolic process" EXACT [] synonym: "inhibition of acetate catabolic process" NARROW [] synonym: "negative regulation of acetate breakdown" EXACT [] synonym: "negative regulation of acetate catabolism" EXACT [] synonym: "negative regulation of acetate degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045733 ! acetate catabolic process relationship: negatively_regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045754 name: positive regulation of acetate catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "activation of acetate catabolic process" NARROW [] synonym: "positive regulation of acetate breakdown" EXACT [] synonym: "positive regulation of acetate catabolism" EXACT [] synonym: "positive regulation of acetate degradation" EXACT [] synonym: "stimulation of acetate catabolic process" NARROW [] synonym: "up regulation of acetate catabolic process" EXACT [] synonym: "up-regulation of acetate catabolic process" EXACT [] synonym: "upregulation of acetate catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045734 ! regulation of acetate catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045733 ! acetate catabolic process relationship: positively_regulates GO:0045733 ! acetate catabolic process [Term] id: GO:0045755 name: negative regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW [] synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT [] is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate is_a: GO:1901458 ! negative regulation of response to acetate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045756 name: positive regulation of initiation of acetate catabolic process by acetate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] synonym: "activation of initiation of acetate catabolic process by acetate" NARROW [] synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT [] synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT [] synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW [] synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT [] synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT [] is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate is_a: GO:0045754 ! positive regulation of acetate catabolic process is_a: GO:1901459 ! positive regulation of response to acetate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate [Term] id: GO:0045757 name: obsolete negative regulation of actin polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. synonym: "negative regulation of actin polymerization and/or depolymerization" EXACT [] is_obsolete: true consider: GO:0030835 consider: GO:0030837 [Term] id: GO:0045758 name: obsolete positive regulation of actin polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. synonym: "positive regulation of actin polymerization and/or depolymerization" EXACT [] is_obsolete: true consider: GO:0030836 consider: GO:0030838 [Term] id: GO:0045759 name: negative regulation of action potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "down regulation of action potential" EXACT [] synonym: "down-regulation of action potential" EXACT [] synonym: "downregulation of action potential" EXACT [] synonym: "inhibition of action potential" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001508 ! action potential relationship: negatively_regulates GO:0001508 ! action potential [Term] id: GO:0045760 name: positive regulation of action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "activation of action potential" NARROW [] synonym: "stimulation of action potential" NARROW [] synonym: "up regulation of action potential" EXACT [] synonym: "up-regulation of action potential" EXACT [] synonym: "upregulation of action potential" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001508 ! action potential relationship: positively_regulates GO:0001508 ! action potential [Term] id: GO:0045761 name: regulation of adenylate cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase regulator" RELATED [] synonym: "regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004016 ! adenylate cyclase activity relationship: regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0045762 name: positive regulation of adenylate cyclase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase activator" RELATED [] synonym: "positive regulation of adenylyl cyclase activity" EXACT [] synonym: "stimulation of adenylate cyclase activity" NARROW [] synonym: "up regulation of adenylate cyclase activity" EXACT [] synonym: "up-regulation of adenylate cyclase activity" EXACT [] synonym: "upregulation of adenylate cyclase activity" EXACT [] is_a: GO:0031281 ! positive regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051349 ! positive regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004016 ! adenylate cyclase activity relationship: positively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0045763 name: negative regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006520 ! cellular amino acid metabolic process relationship: negatively_regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0045764 name: positive regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006520 ! cellular amino acid metabolic process relationship: positively_regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001525 ! angiogenesis relationship: regulates GO:0001525 ! angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001525 ! angiogenesis relationship: positively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0045767 name: obsolete regulation of anti-apoptosis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] comment: This term was made obsolete because it was ill-defined. synonym: "regulation of anti-apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0045768 name: obsolete positive regulation of anti-apoptosis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] comment: This term was made obsolete because it was ill-defined. synonym: "activation of anti-apoptosis" NARROW [] synonym: "positive regulation of anti-apoptosis" EXACT [] synonym: "stimulation of anti-apoptosis" NARROW [] synonym: "up regulation of anti-apoptosis" EXACT [] synonym: "up-regulation of anti-apoptosis" EXACT [] synonym: "upregulation of anti-apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008356 ! asymmetric cell division relationship: negatively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008356 ! asymmetric cell division relationship: positively_regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0045771 name: negative regulation of autophagosome size namespace: biological_process def: "Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators] synonym: "down regulation of autophagic vacuole size" EXACT [] synonym: "down-regulation of autophagic vacuole size" EXACT [] synonym: "downregulation of autophagic vacuole size" EXACT [] synonym: "inhibition of autophagic vacuole size" NARROW [] synonym: "negative regulation of autophagic vacuole size" EXACT [GOC:autophagy] is_a: GO:0016243 ! regulation of autophagosome size [Term] id: GO:0045772 name: positive regulation of autophagosome size namespace: biological_process def: "Any process that increases autophagosome size." [GOC:autophagy, GOC:go_curators] synonym: "activation of autophagic vacuole size" NARROW [] synonym: "positive regulation of autophagic vacuole size" EXACT [GOC:autophagy] synonym: "stimulation of autophagic vacuole size" NARROW [] synonym: "up regulation of autophagic vacuole size" EXACT [] synonym: "up-regulation of autophagic vacuole size" EXACT [] synonym: "upregulation of autophagic vacuole size" EXACT [] is_a: GO:0016243 ! regulation of autophagosome size [Term] id: GO:0045773 name: positive regulation of axon extension namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] synonym: "activation of axon extension" NARROW [] synonym: "stimulation of axon extension" NARROW [] synonym: "up regulation of axon extension" EXACT [] synonym: "up-regulation of axon extension" EXACT [] synonym: "upregulation of axon extension" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0050772 ! positive regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048675 ! axon extension relationship: positively_regulates GO:0048675 ! axon extension [Term] id: GO:0045774 name: negative regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW [] synonym: "negative regulation of beta 2 integrin anabolism" EXACT [] synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "negative regulation of beta 2 integrin formation" EXACT [] synonym: "negative regulation of beta 2 integrin synthesis" EXACT [] is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process is_a: GO:0045720 ! negative regulation of integrin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045775 name: positive regulation of beta 2 integrin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] synonym: "activation of beta 2 integrin biosynthetic process" NARROW [] synonym: "positive regulation of beta 2 integrin anabolism" EXACT [] synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT [] synonym: "positive regulation of beta 2 integrin formation" EXACT [] synonym: "positive regulation of beta 2 integrin synthesis" EXACT [] synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW [] synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT [] synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT [] is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process is_a: GO:0045726 ! positive regulation of integrin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process [Term] id: GO:0045776 name: negative regulation of blood pressure namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio] synonym: "down regulation of blood pressure" EXACT [] synonym: "down-regulation of blood pressure" EXACT [] synonym: "downregulation of blood pressure" EXACT [] synonym: "inhibition of blood pressure" NARROW [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0045777 name: positive regulation of blood pressure namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio] synonym: "activation of blood pressure" NARROW [] synonym: "stimulation of blood pressure" NARROW [] synonym: "up regulation of blood pressure" EXACT [] synonym: "up-regulation of blood pressure" EXACT [] synonym: "upregulation of blood pressure" EXACT [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0045778 name: positive regulation of ossification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "activation of ossification" NARROW [] synonym: "positive regulation of bone biosynthesis" EXACT [] synonym: "positive regulation of bone formation" EXACT [] synonym: "stimulation of ossification" NARROW [] synonym: "up regulation of ossification" EXACT [] synonym: "up-regulation of ossification" EXACT [] synonym: "upregulation of ossification" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001503 ! ossification relationship: positively_regulates GO:0001503 ! ossification [Term] id: GO:0045779 name: negative regulation of bone resorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "down regulation of bone resorption" EXACT [] synonym: "down-regulation of bone resorption" EXACT [] synonym: "downregulation of bone resorption" EXACT [] synonym: "inhibition of bone resorption" NARROW [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046851 ! negative regulation of bone remodeling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045453 ! bone resorption relationship: negatively_regulates GO:0045453 ! bone resorption [Term] id: GO:0045780 name: positive regulation of bone resorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "activation of bone resorption" NARROW [] synonym: "stimulation of bone resorption" NARROW [] synonym: "up regulation of bone resorption" EXACT [] synonym: "up-regulation of bone resorption" EXACT [] synonym: "upregulation of bone resorption" EXACT [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046852 ! positive regulation of bone remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045453 ! bone resorption relationship: positively_regulates GO:0045453 ! bone resorption [Term] id: GO:0045781 name: negative regulation of cell budding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding." [GOC:go_curators] synonym: "down regulation of cell budding" EXACT [] synonym: "down-regulation of cell budding" EXACT [] synonym: "downregulation of cell budding" EXACT [] synonym: "inhibition of cell budding" NARROW [] synonym: "negative regulation of budding" BROAD [] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1903665 ! negative regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007114 ! cell budding relationship: negatively_regulates GO:0007114 ! cell budding [Term] id: GO:0045782 name: positive regulation of cell budding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators] synonym: "activation of cell budding" NARROW [] synonym: "positive regulation of budding" BROAD [] synonym: "stimulation of cell budding" NARROW [] synonym: "up regulation of cell budding" EXACT [] synonym: "up-regulation of cell budding" EXACT [] synonym: "upregulation of cell budding" EXACT [] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1903666 ! positive regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007114 ! cell budding relationship: positively_regulates GO:0007114 ! cell budding [Term] id: GO:0045783 name: obsolete negative regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). synonym: "negative regulation of calcium in ER" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0045784 name: obsolete positive regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). synonym: "positive regulation of calcium in ER" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007155 ! cell adhesion relationship: positively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007049 ! cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007049 ! cell cycle relationship: positively_regulates GO:0007049 ! cell cycle [Term] id: GO:0045792 name: negative regulation of cell size namespace: biological_process def: "Any process that reduces cell size." [GOC:go_curators] synonym: "down regulation of cell size" EXACT [] synonym: "down-regulation of cell size" EXACT [] synonym: "downregulation of cell size" EXACT [] synonym: "inhibition of cell size" NARROW [] is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0045793 name: positive regulation of cell size namespace: biological_process def: "Any process that increases cell size." [GOC:go_curators] synonym: "activation of cell size" NARROW [] synonym: "stimulation of cell size" NARROW [] synonym: "up regulation of cell size" EXACT [] synonym: "up-regulation of cell size" EXACT [] synonym: "upregulation of cell size" EXACT [] is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0045794 name: negative regulation of cell volume namespace: biological_process def: "Any process that decreases cell volume." [GOC:go_curators] synonym: "cell regulatory volume decrease" RELATED [PMID:12388065] synonym: "RVD" RELATED [PMID:12388065] is_a: GO:0006884 ! cell volume homeostasis [Term] id: GO:0045795 name: positive regulation of cell volume namespace: biological_process def: "Any process that increases cell volume." [GOC:go_curators] is_a: GO:0006884 ! cell volume homeostasis [Term] id: GO:0045796 name: negative regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] synonym: "down regulation of cholesterol absorption" EXACT [] synonym: "down-regulation of cholesterol absorption" EXACT [] synonym: "downregulation of cholesterol absorption" EXACT [] synonym: "inhibition of cholesterol absorption" NARROW [] is_a: GO:0030300 ! regulation of intestinal cholesterol absorption is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:1904730 ! negative regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030299 ! intestinal cholesterol absorption relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0045797 name: positive regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] synonym: "activation of cholesterol absorption" NARROW [] synonym: "stimulation of cholesterol absorption" NARROW [] synonym: "up regulation of cholesterol absorption" EXACT [] synonym: "up-regulation of cholesterol absorption" EXACT [] synonym: "upregulation of cholesterol absorption" EXACT [] is_a: GO:0030300 ! regulation of intestinal cholesterol absorption is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:1904731 ! positive regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030299 ! intestinal cholesterol absorption relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0045798 name: negative regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "down regulation of chromatin assembly or disassembly" EXACT [] synonym: "down-regulation of chromatin assembly or disassembly" EXACT [] synonym: "downregulation of chromatin assembly or disassembly" EXACT [] synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006333 ! chromatin assembly or disassembly relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0045799 name: positive regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "positive regulation of chromatin assembly/disassembly" EXACT [] synonym: "stimulation of chromatin assembly or disassembly" NARROW [] synonym: "up regulation of chromatin assembly or disassembly" EXACT [] synonym: "up-regulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin assembly or disassembly" EXACT [] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006333 ! chromatin assembly or disassembly relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0045800 name: negative regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "down regulation of cuticle tanning" EXACT [] synonym: "down-regulation of cuticle tanning" EXACT [] synonym: "downregulation of cuticle tanning" EXACT [] synonym: "inhibition of cuticle tanning" NARROW [] synonym: "negative regulation of cuticle hardening" NARROW [] synonym: "negative regulation of cuticle tanning" EXACT [] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization relationship: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization [Term] id: GO:0045801 name: positive regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "activation of cuticle tanning" NARROW [] synonym: "positive regulation of cuticle hardening" NARROW [] synonym: "positive regulation of cuticle tanning" EXACT [] synonym: "stimulation of cuticle tanning" NARROW [] synonym: "up regulation of cuticle tanning" EXACT [] synonym: "up-regulation of cuticle tanning" EXACT [] synonym: "upregulation of cuticle tanning" EXACT [] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization relationship: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization [Term] id: GO:0045802 name: obsolete negative regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. synonym: "negative regulation of cytoskeleton" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0045803 name: obsolete positive regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. synonym: "positive regulation of cytoskeleton" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0045804 name: negative regulation of eclosion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators] synonym: "down regulation of eclosion" EXACT [] synonym: "down-regulation of eclosion" EXACT [] synonym: "downregulation of eclosion" EXACT [] synonym: "inhibition of eclosion" NARROW [] is_a: GO:0007563 ! regulation of eclosion is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007562 ! eclosion relationship: negatively_regulates GO:0007562 ! eclosion [Term] id: GO:0045805 name: positive regulation of eclosion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators] synonym: "activation of eclosion" NARROW [] synonym: "stimulation of eclosion" NARROW [] synonym: "up regulation of eclosion" EXACT [] synonym: "up-regulation of eclosion" EXACT [] synonym: "upregulation of eclosion" EXACT [] is_a: GO:0007563 ! regulation of eclosion is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007562 ! eclosion relationship: positively_regulates GO:0007562 ! eclosion [Term] id: GO:0045806 name: negative regulation of endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "down regulation of endocytosis" EXACT [] synonym: "down-regulation of endocytosis" EXACT [] synonym: "downregulation of endocytosis" EXACT [] synonym: "inhibition of endocytosis" NARROW [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006897 ! endocytosis relationship: negatively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045807 name: positive regulation of endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "activation of endocytosis" NARROW [] synonym: "stimulation of endocytosis" NARROW [] synonym: "up regulation of endocytosis" EXACT [] synonym: "up-regulation of endocytosis" EXACT [] synonym: "upregulation of endocytosis" EXACT [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006897 ! endocytosis relationship: positively_regulates GO:0006897 ! endocytosis [Term] id: GO:0045808 name: negative regulation of establishment of competence for transformation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] synonym: "down regulation of establishment of competence for transformation" EXACT [] synonym: "down-regulation of establishment of competence for transformation" EXACT [] synonym: "downregulation of establishment of competence for transformation" EXACT [] synonym: "inhibition of establishment of competence for transformation" NARROW [] synonym: "inhibitor of the establishment of competence for transformation activity" RELATED [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045304 ! regulation of establishment of competence for transformation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030420 ! establishment of competence for transformation relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045809 name: positive regulation of establishment of competence for transformation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] synonym: "activation of establishment of competence for transformation" NARROW [] synonym: "activator of the establishment of competence for transformation activity" RELATED [] synonym: "stimulation of establishment of competence for transformation" NARROW [] synonym: "up regulation of establishment of competence for transformation" EXACT [] synonym: "up-regulation of establishment of competence for transformation" EXACT [] synonym: "upregulation of establishment of competence for transformation" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045304 ! regulation of establishment of competence for transformation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030420 ! establishment of competence for transformation relationship: positively_regulates GO:0030420 ! establishment of competence for transformation [Term] id: GO:0045812 name: negative regulation of Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled-2 signaling pathway" EXACT [] synonym: "down-regulation of frizzled-2 signaling pathway" EXACT [] synonym: "downregulation of frizzled-2 signaling pathway" EXACT [] synonym: "inhibition of frizzled-2 signaling pathway" NARROW [] synonym: "negative regulation of frizzled-2 signaling pathway" EXACT [] synonym: "negative regulation of frizzled-2 signalling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "negative regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway relationship: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway [Term] id: GO:0045813 name: positive regulation of Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:go_curators] synonym: "activation of frizzled-2 signaling pathway" NARROW [] synonym: "positive regulation of frizzled-2 signaling pathway" EXACT [] synonym: "positive regulation of frizzled-2 signalling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "positive regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] synonym: "stimulation of frizzled-2 signaling pathway" NARROW [] synonym: "up regulation of frizzled-2 signaling pathway" EXACT [] synonym: "up-regulation of frizzled-2 signaling pathway" EXACT [] synonym: "upregulation of frizzled-2 signaling pathway" EXACT [] is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway relationship: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway [Term] id: GO:0045814 name: negative regulation of gene expression, epigenetic namespace: biological_process def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators] synonym: "down regulation of gene expression, epigenetic" EXACT [] synonym: "down-regulation of gene expression, epigenetic" EXACT [] synonym: "downregulation of gene expression, epigenetic" EXACT [] synonym: "inhibition of gene expression, epigenetic" NARROW [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0045815 name: positive regulation of gene expression, epigenetic namespace: biological_process def: "Any epigenetic process that activates or increases the rate of gene expression." [GOC:go_curators] synonym: "activation of gene expression, epigenetic" NARROW [] synonym: "stimulation of gene expression, epigenetic" NARROW [] synonym: "up regulation of gene expression, epigenetic" EXACT [] synonym: "up-regulation of gene expression, epigenetic" EXACT [] synonym: "upregulation of gene expression, epigenetic" EXACT [] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0045818 name: negative regulation of glycogen catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "down regulation of glycogen catabolic process" EXACT [] synonym: "down-regulation of glycogen catabolic process" EXACT [] synonym: "downregulation of glycogen catabolic process" EXACT [] synonym: "inhibition of glycogen catabolic process" NARROW [] synonym: "negative regulation of glycogen breakdown" EXACT [] synonym: "negative regulation of glycogen catabolism" EXACT [] synonym: "negative regulation of glycogen degradation" EXACT [] synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0070874 ! negative regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005980 ! glycogen catabolic process relationship: negatively_regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0045819 name: positive regulation of glycogen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "activation of glycogen catabolic process" NARROW [] synonym: "positive regulation of glycogen breakdown" EXACT [] synonym: "positive regulation of glycogen catabolism" EXACT [] synonym: "positive regulation of glycogen degradation" EXACT [] synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl] synonym: "stimulation of glycogen catabolic process" NARROW [] synonym: "up regulation of glycogen catabolic process" EXACT [] synonym: "up-regulation of glycogen catabolic process" EXACT [] synonym: "upregulation of glycogen catabolic process" EXACT [] is_a: GO:0005981 ! regulation of glycogen catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005980 ! glycogen catabolic process relationship: positively_regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0045820 name: negative regulation of glycolytic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators] synonym: "down regulation of glycolysis" EXACT [] synonym: "down-regulation of glycolysis" EXACT [] synonym: "downregulation of glycolysis" EXACT [] synonym: "inhibition of glycolysis" NARROW [] is_a: GO:0006110 ! regulation of glycolytic process is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1903579 ! negative regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006096 ! glycolytic process relationship: negatively_regulates GO:0006096 ! glycolytic process [Term] id: GO:0045821 name: positive regulation of glycolytic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators] synonym: "activation of glycolysis" NARROW [] synonym: "stimulation of glycolysis" NARROW [] synonym: "up regulation of glycolysis" EXACT [] synonym: "up-regulation of glycolysis" EXACT [] synonym: "upregulation of glycolysis" EXACT [] is_a: GO:0006110 ! regulation of glycolytic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1903580 ! positive regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006096 ! glycolytic process relationship: positively_regulates GO:0006096 ! glycolytic process [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060047 ! heart contraction relationship: negatively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060047 ! heart contraction relationship: positively_regulates GO:0060047 ! heart contraction [Term] id: GO:0045824 name: negative regulation of innate immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] synonym: "down regulation of innate immune response" EXACT [] synonym: "down-regulation of innate immune response" EXACT [] synonym: "downregulation of innate immune response" EXACT [] synonym: "inhibition of innate immune response" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045087 ! innate immune response relationship: negatively_regulates GO:0045087 ! innate immune response [Term] id: GO:0045825 name: obsolete negative regulation of intermediate filament polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" EXACT [] is_obsolete: true consider: GO:0030840 consider: GO:0030843 [Term] id: GO:0045826 name: obsolete positive regulation of intermediate filament polymerization and/or depolymerization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] comment: This term was made obsolete because it has been split. synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" EXACT [] is_obsolete: true consider: GO:0030841 consider: GO:0030844 [Term] id: GO:0045827 name: negative regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] synonym: "down regulation of isoprenoid metabolic process" EXACT [] synonym: "down-regulation of isoprenoid metabolic process" EXACT [] synonym: "downregulation of isoprenoid metabolic process" EXACT [] synonym: "inhibition of isoprenoid metabolic process" NARROW [] synonym: "negative regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006720 ! isoprenoid metabolic process relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045828 name: positive regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] synonym: "activation of isoprenoid metabolic process" NARROW [] synonym: "positive regulation of isoprenoid metabolism" EXACT [] synonym: "stimulation of isoprenoid metabolic process" NARROW [] synonym: "up regulation of isoprenoid metabolic process" EXACT [] synonym: "up-regulation of isoprenoid metabolic process" EXACT [] synonym: "upregulation of isoprenoid metabolic process" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006720 ! isoprenoid metabolic process relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0045829 name: negative regulation of isotype switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "down regulation of isotype switching" EXACT [] synonym: "down-regulation of isotype switching" EXACT [] synonym: "downregulation of isotype switching" EXACT [] synonym: "inhibition of isotype switching" NARROW [] synonym: "negative regulation of class switch recombination" EXACT [] synonym: "negative regulation of class switching" EXACT [] synonym: "negative regulation of isotype switch recombination" EXACT [] is_a: GO:0002638 ! negative regulation of immunoglobulin production is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0050869 ! negative regulation of B cell activation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045190 ! isotype switching relationship: negatively_regulates GO:0045190 ! isotype switching [Term] id: GO:0045830 name: positive regulation of isotype switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators] synonym: "activation of isotype switching" NARROW [] synonym: "positive regulation of class switch recombination" EXACT [] synonym: "positive regulation of class switching" EXACT [] synonym: "positive regulation of isotype switch recombination" EXACT [] synonym: "stimulation of isotype switching" NARROW [] synonym: "up regulation of isotype switching" EXACT [] synonym: "up-regulation of isotype switching" EXACT [] synonym: "upregulation of isotype switching" EXACT [] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0045191 ! regulation of isotype switching is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0050871 ! positive regulation of B cell activation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045190 ! isotype switching relationship: positively_regulates GO:0045190 ! isotype switching [Term] id: GO:0045831 name: negative regulation of light-activated channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] synonym: "down regulation of light-activated channel activity" EXACT [] synonym: "down-regulation of light-activated channel activity" EXACT [] synonym: "downregulation of light-activated channel activity" EXACT [] synonym: "inhibition of light-activated channel activity" NARROW [] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010461 ! light-activated ion channel activity relationship: negatively_regulates GO:0010461 ! light-activated ion channel activity [Term] id: GO:0045832 name: positive regulation of light-activated channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] synonym: "activation of light-activated channel activity" NARROW [] synonym: "stimulation of light-activated channel activity" NARROW [] synonym: "up regulation of light-activated channel activity" EXACT [] synonym: "up-regulation of light-activated channel activity" EXACT [] synonym: "upregulation of light-activated channel activity" EXACT [] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010461 ! light-activated ion channel activity relationship: positively_regulates GO:0010461 ! light-activated ion channel activity [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006629 ! lipid metabolic process relationship: negatively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006629 ! lipid metabolic process relationship: positively_regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140013 ! meiotic nuclear division relationship: negatively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0140013 ! meiotic nuclear division relationship: positively_regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0045837 name: negative regulation of membrane potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] synonym: "down regulation of membrane potential" EXACT [] synonym: "down-regulation of membrane potential" EXACT [] synonym: "downregulation of membrane potential" EXACT [] synonym: "inhibition of membrane potential" NARROW [] synonym: "reduction of membrane potential" EXACT [GOC:rph] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0045838 name: positive regulation of membrane potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] synonym: "activation of membrane potential" NARROW [] synonym: "elevation of membrane potential" EXACT [GOC:rph] synonym: "stimulation of membrane potential" NARROW [] synonym: "up regulation of membrane potential" EXACT [] synonym: "up-regulation of membrane potential" EXACT [] synonym: "upregulation of membrane potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140014 ! mitotic nuclear division relationship: negatively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0140014 ! mitotic nuclear division relationship: positively_regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0045841 name: negative regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators] synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle [Term] id: GO:0045842 name: positive regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators] synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle [Term] id: GO:0045843 name: negative regulation of striated muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "down regulation of striated muscle development" EXACT [] synonym: "down-regulation of striated muscle development" EXACT [] synonym: "downregulation of striated muscle development" EXACT [] synonym: "inhibition of striated muscle development" NARROW [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048635 ! negative regulation of muscle organ development is_a: GO:1901862 ! negative regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014706 ! striated muscle tissue development relationship: negatively_regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0045844 name: positive regulation of striated muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "activation of striated muscle development" NARROW [] synonym: "stimulation of striated muscle development" NARROW [] synonym: "up regulation of striated muscle development" EXACT [] synonym: "up-regulation of striated muscle development" EXACT [] synonym: "upregulation of striated muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048636 ! positive regulation of muscle organ development is_a: GO:1901863 ! positive regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014706 ! striated muscle tissue development relationship: positively_regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0045847 name: negative regulation of nitrogen utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] synonym: "down regulation of nitrogen utilization" EXACT [] synonym: "down-regulation of nitrogen utilization" EXACT [] synonym: "downregulation of nitrogen utilization" EXACT [] synonym: "inhibition of nitrogen utilization" NARROW [] is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019740 ! nitrogen utilization relationship: negatively_regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0045848 name: positive regulation of nitrogen utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] synonym: "activation of nitrogen utilization" NARROW [] synonym: "stimulation of nitrogen utilization" NARROW [] synonym: "up regulation of nitrogen utilization" EXACT [] synonym: "up-regulation of nitrogen utilization" EXACT [] synonym: "upregulation of nitrogen utilization" EXACT [] is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019740 ! nitrogen utilization relationship: positively_regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0045849 name: negative regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of nurse cell apoptosis" EXACT [] synonym: "down-regulation of nurse cell apoptosis" EXACT [] synonym: "downregulation of nurse cell apoptosis" EXACT [] synonym: "inhibition of nurse cell apoptosis" NARROW [] synonym: "negative regulation of nurse cell apoptosis" NARROW [] is_a: GO:0045477 ! regulation of nurse cell apoptotic process is_a: GO:1904746 ! negative regulation of apoptotic process involved in development is_a: GO:1905880 ! negative regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045476 ! nurse cell apoptotic process relationship: negatively_regulates GO:0045476 ! nurse cell apoptotic process [Term] id: GO:0045850 name: positive regulation of nurse cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of nurse cell apoptosis" NARROW [] synonym: "positive regulation of nurse cell apoptosis" NARROW [] synonym: "stimulation of nurse cell apoptosis" NARROW [] synonym: "up regulation of nurse cell apoptosis" EXACT [] synonym: "up-regulation of nurse cell apoptosis" EXACT [] synonym: "upregulation of nurse cell apoptosis" EXACT [] is_a: GO:0045477 ! regulation of nurse cell apoptotic process is_a: GO:1904747 ! positive regulation of apoptotic process involved in development is_a: GO:1905881 ! positive regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045476 ! nurse cell apoptotic process relationship: positively_regulates GO:0045476 ! nurse cell apoptotic process [Term] id: GO:0045851 name: pH reduction namespace: biological_process def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] synonym: "acidification" EXACT [] is_a: GO:0006885 ! regulation of pH [Term] id: GO:0045852 name: pH elevation namespace: biological_process def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] is_a: GO:0006885 ! regulation of pH [Term] id: GO:0045853 name: negative regulation of bicoid mRNA localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] synonym: "down regulation of bicoid mRNA localization" EXACT [] synonym: "down-regulation of bicoid mRNA localization" EXACT [] synonym: "downregulation of bicoid mRNA localization" EXACT [] synonym: "inhibition of bicoid mRNA localization" NARROW [] synonym: "negative regulation of bicoid mRNA localisation" EXACT [GOC:mah] is_a: GO:0008359 ! regulation of bicoid mRNA localization is_a: GO:0060283 ! negative regulation of oocyte development is_a: GO:1902876 ! negative regulation of embryonic pattern specification is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:1904581 ! negative regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045450 ! bicoid mRNA localization relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0045854 name: positive regulation of bicoid mRNA localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] synonym: "activation of bicoid mRNA localization" NARROW [] synonym: "positive regulation of bicoid mRNA localisation" EXACT [GOC:mah] synonym: "stimulation of bicoid mRNA localization" NARROW [] synonym: "up regulation of bicoid mRNA localization" EXACT [] synonym: "up-regulation of bicoid mRNA localization" EXACT [] synonym: "upregulation of bicoid mRNA localization" EXACT [] is_a: GO:0008359 ! regulation of bicoid mRNA localization is_a: GO:0060282 ! positive regulation of oocyte development is_a: GO:1902877 ! positive regulation of embryonic pattern specification is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:1904582 ! positive regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045450 ! bicoid mRNA localization relationship: positively_regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0045855 name: negative regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "down regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "downregulation of pole plasm oskar mRNA localization" EXACT [] synonym: "inhibition of pole plasm oskar mRNA localization" NARROW [] synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "negative regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060283 ! negative regulation of oocyte development is_a: GO:1902876 ! negative regulation of embryonic pattern specification is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:1904581 ! negative regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0045856 name: positive regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] synonym: "activation of pole plasm oskar mRNA localization" NARROW [] synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "positive regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] synonym: "stimulation of pole plasm oskar mRNA localization" NARROW [] synonym: "up regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT [] synonym: "upregulation of pole plasm oskar mRNA localization" EXACT [] is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060282 ! positive regulation of oocyte development is_a: GO:1902877 ! positive regulation of embryonic pattern specification is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:1904582 ! positive regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0045857 name: negative regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of protein activity, epigenetic" EXACT [] synonym: "down-regulation of protein activity, epigenetic" EXACT [] synonym: "downregulation of protein activity, epigenetic" EXACT [] synonym: "inhibition of protein activity, epigenetic" NARROW [] synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] is_a: GO:0040030 ! regulation of molecular function, epigenetic is_a: GO:0044092 ! negative regulation of molecular function [Term] id: GO:0045858 name: positive regulation of molecular function, epigenetic namespace: biological_process def: "Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein activity, epigenetic" NARROW [] synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of protein activity, epigenetic" NARROW [] synonym: "up regulation of protein activity, epigenetic" EXACT [] synonym: "up-regulation of protein activity, epigenetic" EXACT [] synonym: "upregulation of protein activity, epigenetic" EXACT [] is_a: GO:0040030 ! regulation of molecular function, epigenetic is_a: GO:0044093 ! positive regulation of molecular function [Term] id: GO:0045859 name: regulation of protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004672 ! protein kinase activity relationship: regulates GO:0004672 ! protein kinase activity [Term] id: GO:0045860 name: positive regulation of protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] synonym: "stimulation of protein kinase activity" NARROW [] synonym: "up regulation of protein kinase activity" EXACT [] synonym: "up-regulation of protein kinase activity" EXACT [] synonym: "upregulation of protein kinase activity" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004672 ! protein kinase activity relationship: positively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006508 ! proteolysis relationship: negatively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006508 ! proteolysis relationship: positively_regulates GO:0006508 ! proteolysis [Term] id: GO:0045863 name: negative regulation of pteridine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] synonym: "down regulation of pteridine metabolic process" EXACT [] synonym: "down-regulation of pteridine metabolic process" EXACT [] synonym: "downregulation of pteridine metabolic process" EXACT [] synonym: "inhibition of pteridine metabolic process" NARROW [] synonym: "negative regulation of pteridine metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019889 ! pteridine metabolic process relationship: negatively_regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0045864 name: positive regulation of pteridine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] synonym: "activation of pteridine metabolic process" NARROW [] synonym: "positive regulation of pteridine metabolism" EXACT [] synonym: "stimulation of pteridine metabolic process" NARROW [] synonym: "up regulation of pteridine metabolic process" EXACT [] synonym: "up-regulation of pteridine metabolic process" EXACT [] synonym: "upregulation of pteridine metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019889 ! pteridine metabolic process relationship: positively_regulates GO:0019889 ! pteridine metabolic process [Term] id: GO:0045865 name: obsolete regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. synonym: "regulation of recombination within rDNA repeats" EXACT [] is_obsolete: true replaced_by: GO:0000019 [Term] id: GO:0045866 name: obsolete positive regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. synonym: "positive regulation of recombination within rDNA repeats" EXACT [] is_obsolete: true consider: GO:0045951 [Term] id: GO:0045869 name: negative regulation of single stranded viral RNA replication via double stranded DNA intermediate namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators] synonym: "down regulation of retroviral genome replication" EXACT [] synonym: "down-regulation of retroviral genome replication" EXACT [] synonym: "downregulation of retroviral genome replication" EXACT [] synonym: "inhibition of retroviral genome replication" NARROW [] synonym: "negative regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] synonym: "regulation of retroviral genome replication" RELATED [] is_a: GO:0045071 ! negative regulation of viral genome replication is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate relationship: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate [Term] id: GO:0045870 name: positive regulation of single stranded viral RNA replication via double stranded DNA intermediate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] synonym: "activation of retroviral genome replication" NARROW [] synonym: "positive regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] synonym: "stimulation of retroviral genome replication" NARROW [] synonym: "up regulation of retroviral genome replication" EXACT [] synonym: "up-regulation of retroviral genome replication" EXACT [] synonym: "upregulation of retroviral genome replication" EXACT [] is_a: GO:0045070 ! positive regulation of viral genome replication is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate relationship: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate [Term] id: GO:0045871 name: negative regulation of rhodopsin gene expression namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of rhodopsin gene activity" EXACT [] synonym: "down-regulation of rhodopsin gene activity" EXACT [] synonym: "downregulation of rhodopsin gene activity" EXACT [] synonym: "inhibition of rhodopsin gene activity" NARROW [] synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0007468 ! regulation of rhodopsin gene expression is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0045872 name: positive regulation of rhodopsin gene expression namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of rhodopsin gene activity" NARROW [] synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of rhodopsin gene activity" NARROW [] synonym: "up regulation of rhodopsin gene activity" EXACT [] synonym: "up-regulation of rhodopsin gene activity" EXACT [] synonym: "upregulation of rhodopsin gene activity" EXACT [] is_a: GO:0007468 ! regulation of rhodopsin gene expression is_a: GO:0010628 ! positive regulation of gene expression [Term] id: GO:0045873 name: negative regulation of sevenless signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "down regulation of sevenless signaling pathway" EXACT [] synonym: "down-regulation of sevenless signaling pathway" EXACT [] synonym: "downregulation of sevenless signaling pathway" EXACT [] synonym: "inhibition of sevenless signaling pathway" NARROW [] synonym: "negative regulation of sev signaling pathway" EXACT [] synonym: "negative regulation of sevenless signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0045501 ! regulation of sevenless signaling pathway is_a: GO:0045677 ! negative regulation of R7 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045500 ! sevenless signaling pathway relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045874 name: positive regulation of sevenless signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] synonym: "activation of sevenless signaling pathway" NARROW [] synonym: "positive regulation of sev signaling pathway" EXACT [] synonym: "positive regulation of sevenless signalling pathway" EXACT [] synonym: "stimulation of sevenless signaling pathway" NARROW [] synonym: "up regulation of sevenless signaling pathway" EXACT [] synonym: "up-regulation of sevenless signaling pathway" EXACT [] synonym: "upregulation of sevenless signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0045501 ! regulation of sevenless signaling pathway is_a: GO:0045678 ! positive regulation of R7 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045500 ! sevenless signaling pathway relationship: positively_regulates GO:0045500 ! sevenless signaling pathway [Term] id: GO:0045875 name: negative regulation of sister chromatid cohesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "down regulation of sister chromatid cohesion" EXACT [] synonym: "down-regulation of sister chromatid cohesion" EXACT [] synonym: "downregulation of sister chromatid cohesion" EXACT [] synonym: "inhibition of sister chromatid cohesion" NARROW [] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0033046 ! negative regulation of sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007062 ! sister chromatid cohesion relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0045876 name: positive regulation of sister chromatid cohesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] synonym: "activation of sister chromatid cohesion" NARROW [] synonym: "stimulation of sister chromatid cohesion" NARROW [] synonym: "up regulation of sister chromatid cohesion" EXACT [] synonym: "up-regulation of sister chromatid cohesion" EXACT [] synonym: "upregulation of sister chromatid cohesion" EXACT [] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007062 ! sister chromatid cohesion relationship: positively_regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0045879 name: negative regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0045877 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "down regulation of smoothened signaling pathway" EXACT [] synonym: "down-regulation of smoothened signaling pathway" EXACT [] synonym: "downregulation of smoothened signaling pathway" EXACT [] synonym: "inhibition of smoothened signaling pathway" NARROW [] synonym: "negative regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of smoothened activity" RELATED [] synonym: "negative regulation of smoothened by patched" NARROW [] synonym: "negative regulation of smoothened receptor activity by patched" RELATED [] synonym: "negative regulation of smoothened signalling pathway" EXACT [] is_a: GO:0008589 ! regulation of smoothened signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007224 ! smoothened signaling pathway relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0045880 name: positive regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0045878 def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "activation of smoothened signaling pathway" NARROW [] synonym: "positive regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "positive regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "positive regulation of smoothened by patched" RELATED [] synonym: "positive regulation of smoothened receptor activity by patched" RELATED [] synonym: "positive regulation of smoothened signalling pathway" EXACT [] synonym: "stimulation of smoothened signaling pathway" NARROW [] synonym: "up regulation of smoothened signaling pathway" EXACT [] synonym: "up-regulation of smoothened signaling pathway" EXACT [] synonym: "upregulation of smoothened signaling pathway" EXACT [] is_a: GO:0008589 ! regulation of smoothened signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007224 ! smoothened signaling pathway relationship: positively_regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0045881 name: positive regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators] synonym: "activation of sporulation" NARROW [] synonym: "stimulation of sporulation" NARROW [] synonym: "up regulation of sporulation" EXACT [] synonym: "up-regulation of sporulation" EXACT [] synonym: "upregulation of sporulation" EXACT [] is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore [Term] id: GO:0045882 name: negative regulation of sulfur utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators] synonym: "down regulation of sulfur utilization" EXACT [] synonym: "down-regulation of sulfur utilization" EXACT [] synonym: "downregulation of sulfur utilization" EXACT [] synonym: "inhibition of sulfur utilization" NARROW [] synonym: "negative regulation of sulphur utilization" EXACT [] is_a: GO:0006792 ! regulation of sulfur utilization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006791 ! sulfur utilization relationship: negatively_regulates GO:0006791 ! sulfur utilization [Term] id: GO:0045883 name: positive regulation of sulfur utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators] synonym: "activation of sulfur utilization" NARROW [] synonym: "positive regulation of sulphur utilization" EXACT [] synonym: "stimulation of sulfur utilization" NARROW [] synonym: "up regulation of sulfur utilization" EXACT [] synonym: "up-regulation of sulfur utilization" EXACT [] synonym: "upregulation of sulfur utilization" EXACT [] is_a: GO:0006792 ! regulation of sulfur utilization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006791 ! sulfur utilization relationship: positively_regulates GO:0006791 ! sulfur utilization [Term] id: GO:0045884 name: obsolete regulation of survival gene product expression namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "regulation of survival gene product expression" EXACT [] synonym: "regulation of survival gene products" BROAD [] is_obsolete: true [Term] id: GO:0045885 name: obsolete positive regulation of survival gene product expression namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. synonym: "activation of survival gene product activity" BROAD [] synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "positive regulation of survival gene product expression" EXACT [] synonym: "positive regulation of survival gene products" BROAD [] synonym: "stimulation of survival gene product activity" NARROW [] synonym: "up regulation of survival gene product activity" BROAD [] synonym: "up-regulation of survival gene product activity" BROAD [] synonym: "upregulation of survival gene product activity" BROAD [] is_obsolete: true [Term] id: GO:0045886 name: negative regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW [] is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1904397 ! negative regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction relationship: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0045887 name: positive regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] synonym: "activation of synaptic growth at neuromuscular junction" NARROW [] synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW [] synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT [] synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT [] is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051965 ! positive regulation of synapse assembly is_a: GO:1904398 ! positive regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction relationship: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0045888 name: obsolete regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "regulation of transcription of homeotic gene (Polycomb group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045889 name: obsolete positive regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "positive regulation of transcription of homeotic gene (Polycomb group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045890 name: obsolete regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "regulation of transcription of homeotic gene (trithorax group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045891 name: obsolete negative regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "negative regulation of transcription of homeotic gene (trithorax group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0045892 name: negative regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0016481 alt_id: GO:0032582 alt_id: GO:0061021 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of gene-specific transcription" RELATED [] synonym: "down regulation of transcription, DNA-dependent" EXACT [] synonym: "down-regulation of gene-specific transcription" RELATED [] synonym: "down-regulation of transcription, DNA-dependent" EXACT [] synonym: "downregulation of gene-specific transcription" RELATED [] synonym: "downregulation of transcription, DNA-dependent" EXACT [] synonym: "inhibition of gene-specific transcription" RELATED [] synonym: "inhibition of transcription, DNA-dependent" NARROW [] synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "negative regulation of gene-specific transcription" RELATED [] synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcription repressor activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045893 name: positive regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0043193 alt_id: GO:0045941 alt_id: GO:0061020 def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "activation of gene-specific transcription" RELATED [] synonym: "activation of transcription, DNA-dependent" NARROW [] synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "positive regulation of gene-specific transcription" RELATED [] synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "stimulation of gene-specific transcription" NARROW [] synonym: "stimulation of transcription, DNA-dependent" NARROW [] synonym: "transcription activator activity" RELATED [] synonym: "up regulation of gene-specific transcription" RELATED [] synonym: "up regulation of transcription, DNA-dependent" EXACT [] synonym: "up-regulation of gene-specific transcription" RELATED [] synonym: "up-regulation of transcription, DNA-dependent" EXACT [] synonym: "upregulation of gene-specific transcription" RELATED [] synonym: "upregulation of transcription, DNA-dependent" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006351 ! transcription, DNA-templated relationship: positively_regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0045894 name: negative regulation of mating-type specific transcription, DNA-templated namespace: biological_process def: "Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of transcription, mating-type specific" EXACT [] synonym: "down-regulation of transcription, mating-type specific" EXACT [] synonym: "downregulation of transcription, mating-type specific" EXACT [] synonym: "inhibition of transcription, mating-type specific" NARROW [] synonym: "negative regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0045895 name: positive regulation of mating-type specific transcription, DNA-templated namespace: biological_process def: "Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "activation of transcription, mating-type specific" NARROW [] synonym: "positive regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "stimulation of transcription, mating-type specific" NARROW [] synonym: "up regulation of transcription, mating-type specific" EXACT [] synonym: "up-regulation of transcription, mating-type specific" EXACT [] synonym: "upregulation of transcription, mating-type specific" EXACT [] is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated is_a: GO:0045893 ! positive regulation of transcription, DNA-templated [Term] id: GO:0045896 name: obsolete regulation of transcription during mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "mitotic regulation of transcription" EXACT [] synonym: "regulation of transcription, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0045897 name: obsolete positive regulation of transcription during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "activation of transcription during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription" EXACT [] synonym: "positive regulation of transcription, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription during mitosis" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0045898 name: regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly relationship: regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly [Term] id: GO:0045899 name: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly is_a: GO:0060261 ! positive regulation of transcription initiation from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly relationship: positively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006414 ! translational elongation relationship: negatively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006414 ! translational elongation relationship: positively_regulates GO:0006414 ! translational elongation [Term] id: GO:0045902 name: negative regulation of translational fidelity namespace: biological_process def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] synonym: "down regulation of translational fidelity" EXACT [] synonym: "down-regulation of translational fidelity" EXACT [] synonym: "downregulation of translational fidelity" EXACT [] synonym: "inhibition of translational fidelity" NARROW [] is_a: GO:0006450 ! regulation of translational fidelity is_a: GO:0017148 ! negative regulation of translation [Term] id: GO:0045903 name: positive regulation of translational fidelity namespace: biological_process def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] synonym: "activation of translational fidelity" NARROW [] synonym: "stimulation of translational fidelity" NARROW [] synonym: "up regulation of translational fidelity" EXACT [] synonym: "up-regulation of translational fidelity" EXACT [] synonym: "upregulation of translational fidelity" EXACT [] is_a: GO:0006450 ! regulation of translational fidelity is_a: GO:0045727 ! positive regulation of translation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006415 ! translational termination relationship: negatively_regulates GO:0006415 ! translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006415 ! translational termination relationship: positively_regulates GO:0006415 ! translational termination [Term] id: GO:0045906 name: negative regulation of vasoconstriction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators] synonym: "down regulation of vasoconstriction" EXACT [] synonym: "down-regulation of vasoconstriction" EXACT [] synonym: "downregulation of vasoconstriction" EXACT [] synonym: "inhibition of vasoconstriction" NARROW [] is_a: GO:0019229 ! regulation of vasoconstriction is_a: GO:0097755 ! positive regulation of blood vessel diameter is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042310 ! vasoconstriction relationship: negatively_regulates GO:0042310 ! vasoconstriction [Term] id: GO:0045907 name: positive regulation of vasoconstriction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators] synonym: "activation of vasoconstriction" NARROW [] synonym: "stimulation of vasoconstriction" NARROW [] synonym: "up regulation of vasoconstriction" EXACT [] synonym: "up-regulation of vasoconstriction" EXACT [] synonym: "upregulation of vasoconstriction" EXACT [] is_a: GO:0019229 ! regulation of vasoconstriction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042310 ! vasoconstriction relationship: positively_regulates GO:0042310 ! vasoconstriction [Term] id: GO:0045910 name: negative regulation of DNA recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] synonym: "down regulation of DNA recombination" EXACT [] synonym: "down-regulation of DNA recombination" EXACT [] synonym: "downregulation of DNA recombination" EXACT [] synonym: "inhibition of DNA recombination" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006310 ! DNA recombination relationship: negatively_regulates GO:0006310 ! DNA recombination [Term] id: GO:0045911 name: positive regulation of DNA recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] synonym: "activation of DNA recombination" NARROW [] synonym: "stimulation of DNA recombination" NARROW [] synonym: "up regulation of DNA recombination" EXACT [] synonym: "up-regulation of DNA recombination" EXACT [] synonym: "upregulation of DNA recombination" EXACT [] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006310 ! DNA recombination relationship: positively_regulates GO:0006310 ! DNA recombination [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005975 ! carbohydrate metabolic process relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005975 ! carbohydrate metabolic process relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0045914 name: negative regulation of catecholamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "down regulation of catecholamine metabolic process" EXACT [] synonym: "down-regulation of catecholamine metabolic process" EXACT [] synonym: "downregulation of catecholamine metabolic process" EXACT [] synonym: "inhibition of catecholamine metabolic process" NARROW [] synonym: "negative regulation of catecholamine metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006584 ! catecholamine metabolic process relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0045915 name: positive regulation of catecholamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "activation of catecholamine metabolic process" NARROW [] synonym: "positive regulation of catecholamine metabolism" EXACT [] synonym: "stimulation of catecholamine metabolic process" NARROW [] synonym: "up regulation of catecholamine metabolic process" EXACT [] synonym: "up-regulation of catecholamine metabolic process" EXACT [] synonym: "upregulation of catecholamine metabolic process" EXACT [] is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006584 ! catecholamine metabolic process relationship: positively_regulates GO:0006584 ! catecholamine metabolic process [Term] id: GO:0045916 name: negative regulation of complement activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "down regulation of complement activation" EXACT [] synonym: "down-regulation of complement activation" EXACT [] synonym: "downregulation of complement activation" EXACT [] synonym: "inhibition of complement activation" NARROW [] synonym: "negative regulation of complement cascade" EXACT [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0030449 ! regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006956 ! complement activation relationship: negatively_regulates GO:0006956 ! complement activation [Term] id: GO:0045917 name: positive regulation of complement activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "activation of complement activation" NARROW [] synonym: "positive regulation of complement cascade" EXACT [GOC:add] synonym: "stimulation of complement activation" NARROW [] synonym: "up regulation of complement activation" EXACT [] synonym: "up-regulation of complement activation" EXACT [] synonym: "upregulation of complement activation" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0030449 ! regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006956 ! complement activation relationship: positively_regulates GO:0006956 ! complement activation [Term] id: GO:0045918 name: negative regulation of cytolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators] synonym: "down regulation of cytolysis" EXACT [] synonym: "down-regulation of cytolysis" EXACT [] synonym: "downregulation of cytolysis" EXACT [] synonym: "inhibition of cytolysis" NARROW [] is_a: GO:0042268 ! regulation of cytolysis is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019835 ! cytolysis relationship: negatively_regulates GO:0019835 ! cytolysis [Term] id: GO:0045919 name: positive regulation of cytolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators] synonym: "activation of cytolysis" NARROW [] synonym: "stimulation of cytolysis" NARROW [] synonym: "up regulation of cytolysis" EXACT [] synonym: "up-regulation of cytolysis" EXACT [] synonym: "upregulation of cytolysis" EXACT [] is_a: GO:0042268 ! regulation of cytolysis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019835 ! cytolysis relationship: positively_regulates GO:0019835 ! cytolysis [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006887 ! exocytosis relationship: negatively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006887 ! exocytosis relationship: positively_regulates GO:0006887 ! exocytosis [Term] id: GO:0045922 name: negative regulation of fatty acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "down regulation of fatty acid metabolic process" EXACT [] synonym: "down-regulation of fatty acid metabolic process" EXACT [] synonym: "downregulation of fatty acid metabolic process" EXACT [] synonym: "inhibition of fatty acid metabolic process" NARROW [] synonym: "negative regulation of fatty acid metabolism" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006631 ! fatty acid metabolic process relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0045923 name: positive regulation of fatty acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "activation of fatty acid metabolic process" NARROW [] synonym: "positive regulation of fatty acid metabolism" EXACT [] synonym: "stimulation of fatty acid metabolic process" NARROW [] synonym: "up regulation of fatty acid metabolic process" EXACT [] synonym: "up-regulation of fatty acid metabolic process" EXACT [] synonym: "upregulation of fatty acid metabolic process" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006631 ! fatty acid metabolic process relationship: positively_regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0045924 name: regulation of female receptivity namespace: biological_process alt_id: GO:0060181 def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "female receptivity" RELATED [GOC:dph, GOC:tb] is_a: GO:0060180 ! female mating behavior is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0045925 name: positive regulation of female receptivity namespace: biological_process def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators] synonym: "activation of female receptivity" NARROW [] synonym: "stimulation of female receptivity" NARROW [] synonym: "up regulation of female receptivity" EXACT [] synonym: "up-regulation of female receptivity" EXACT [] synonym: "upregulation of female receptivity" EXACT [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040007 ! growth relationship: negatively_regulates GO:0040007 ! growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040007 ! growth relationship: positively_regulates GO:0040007 ! growth [Term] id: GO:0045928 name: negative regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone metabolic process" EXACT [] synonym: "down-regulation of juvenile hormone metabolic process" EXACT [] synonym: "downregulation of juvenile hormone metabolic process" EXACT [] synonym: "inhibition of juvenile hormone metabolic process" NARROW [] synonym: "negative regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006716 ! juvenile hormone metabolic process relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0045929 name: positive regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone metabolic process" NARROW [] synonym: "positive regulation of juvenile hormone metabolism" EXACT [] synonym: "stimulation of juvenile hormone metabolic process" NARROW [] synonym: "up regulation of juvenile hormone metabolic process" EXACT [] synonym: "up-regulation of juvenile hormone metabolic process" EXACT [] synonym: "upregulation of juvenile hormone metabolic process" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006716 ! juvenile hormone metabolic process relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle relationship: positively_regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0045932 name: negative regulation of muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "down regulation of muscle contraction" EXACT [] synonym: "down-regulation of muscle contraction" EXACT [] synonym: "downregulation of muscle contraction" EXACT [] synonym: "inhibition of muscle contraction" NARROW [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006936 ! muscle contraction relationship: negatively_regulates GO:0006936 ! muscle contraction [Term] id: GO:0045933 name: positive regulation of muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "activation of muscle contraction" NARROW [] synonym: "stimulation of muscle contraction" NARROW [] synonym: "up regulation of muscle contraction" EXACT [] synonym: "up-regulation of muscle contraction" EXACT [] synonym: "upregulation of muscle contraction" EXACT [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006936 ! muscle contraction relationship: positively_regulates GO:0006936 ! muscle contraction [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0045938 name: positive regulation of circadian sleep/wake cycle, sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "positive regulation of sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT [] is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep [Term] id: GO:0045939 name: negative regulation of steroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "down regulation of steroid metabolic process" EXACT [] synonym: "down-regulation of steroid metabolic process" EXACT [] synonym: "downregulation of steroid metabolic process" EXACT [] synonym: "inhibition of steroid metabolic process" NARROW [] synonym: "negative regulation of steroid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008202 ! steroid metabolic process relationship: negatively_regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0045940 name: positive regulation of steroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "activation of steroid metabolic process" NARROW [] synonym: "positive regulation of steroid metabolism" EXACT [] synonym: "stimulation of steroid metabolic process" NARROW [] synonym: "up regulation of steroid metabolic process" EXACT [] synonym: "up-regulation of steroid metabolic process" EXACT [] synonym: "upregulation of steroid metabolic process" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008202 ! steroid metabolic process relationship: positively_regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0045942 name: negative regulation of phosphorus utilization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] synonym: "down regulation of phosphorus utilization" EXACT [] synonym: "down-regulation of phosphorus utilization" EXACT [] synonym: "downregulation of phosphorus utilization" EXACT [] synonym: "inhibition of phosphorus utilization" NARROW [] is_a: GO:0006795 ! regulation of phosphorus utilization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006794 ! phosphorus utilization relationship: negatively_regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0045943 name: positive regulation of transcription by RNA polymerase I namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH] synonym: "activation of transcription from RNA polymerase I promoter" NARROW [] synonym: "positive regulation of transcription from Pol I promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW [] synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006360 ! transcription by RNA polymerase I relationship: positively_regulates GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0045944 name: positive regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010552 alt_id: GO:0045817 def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] synonym: "positive regulation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II relationship: positively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0045945 name: positive regulation of transcription by RNA polymerase III namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH] synonym: "activation of transcription from RNA polymerase III promoter" NARROW [] synonym: "positive regulation of transcription from Pol III promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW [] synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006359 ! regulation of transcription by RNA polymerase III is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006383 ! transcription by RNA polymerase III relationship: positively_regulates GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006413 ! translational initiation relationship: negatively_regulates GO:0006413 ! translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006413 ! translational initiation relationship: positively_regulates GO:0006413 ! translational initiation [Term] id: GO:0045949 name: positive regulation of phosphorus utilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] synonym: "activation of phosphorus utilization" NARROW [] synonym: "stimulation of phosphorus utilization" NARROW [] synonym: "up regulation of phosphorus utilization" EXACT [] synonym: "up-regulation of phosphorus utilization" EXACT [] synonym: "upregulation of phosphorus utilization" EXACT [] is_a: GO:0006795 ! regulation of phosphorus utilization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006794 ! phosphorus utilization relationship: positively_regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0045950 name: negative regulation of mitotic recombination namespace: biological_process def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] synonym: "down regulation of mitotic recombination" EXACT [] synonym: "down-regulation of mitotic recombination" EXACT [] synonym: "downregulation of mitotic recombination" EXACT [] synonym: "inhibition of mitotic recombination" NARROW [] synonym: "negative regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0045910 ! negative regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006312 ! mitotic recombination relationship: negatively_regulates GO:0006312 ! mitotic recombination [Term] id: GO:0045951 name: positive regulation of mitotic recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "activation of mitotic recombination" NARROW [] synonym: "positive regulation of recombination within rDNA repeats" NARROW [] synonym: "stimulation of mitotic recombination" NARROW [] synonym: "up regulation of mitotic recombination" EXACT [] synonym: "up-regulation of mitotic recombination" EXACT [] synonym: "upregulation of mitotic recombination" EXACT [] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0045911 ! positive regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006312 ! mitotic recombination relationship: positively_regulates GO:0006312 ! mitotic recombination [Term] id: GO:0045952 name: regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone breakdown" EXACT [] synonym: "regulation of juvenile hormone catabolism" EXACT [] synonym: "regulation of juvenile hormone degradation" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006719 ! juvenile hormone catabolic process relationship: regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045953 name: negative regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of natural killer cell mediated cell death" EXACT [] synonym: "negative regulation of natural killer cell mediated cell killing" EXACT [] synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cell death" EXACT [] synonym: "negative regulation of NK cell mediated cell killing" EXACT [] synonym: "negative regulation of NK cell mediated cytolysis" RELATED [] synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0045954 name: positive regulation of natural killer cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of natural killer cell mediated cell death" EXACT [] synonym: "positive regulation of natural killer cell mediated cell killing" EXACT [] synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cell death" EXACT [] synonym: "positive regulation of NK cell mediated cell killing" EXACT [] synonym: "positive regulation of NK cell mediated cytolysis" RELATED [] synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT [] synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0045955 name: negative regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "down regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "downregulation of calcium ion-dependent exocytosis" EXACT [] synonym: "inhibition of calcium ion-dependent exocytosis" NARROW [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:1903306 ! negative regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017156 ! calcium-ion regulated exocytosis relationship: negatively_regulates GO:0017156 ! calcium-ion regulated exocytosis [Term] id: GO:0045956 name: positive regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] synonym: "activation of calcium ion-dependent exocytosis" NARROW [] synonym: "stimulation of calcium ion-dependent exocytosis" NARROW [] synonym: "up regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT [] synonym: "upregulation of calcium ion-dependent exocytosis" EXACT [] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:1903307 ! positive regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017156 ! calcium-ion regulated exocytosis relationship: positively_regulates GO:0017156 ! calcium-ion regulated exocytosis [Term] id: GO:0045957 name: negative regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] synonym: "down regulation of complement activation, alternative pathway" EXACT [] synonym: "down-regulation of complement activation, alternative pathway" EXACT [] synonym: "downregulation of complement activation, alternative pathway" EXACT [] synonym: "inhibition of complement activation, alternative pathway" NARROW [] synonym: "negative regulation of complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0030451 ! regulation of complement activation, alternative pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006957 ! complement activation, alternative pathway relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0045958 name: positive regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] synonym: "activation of complement activation, alternative pathway" NARROW [] synonym: "positive regulation of complement cascade, alternative pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, alternative pathway" NARROW [] synonym: "up regulation of complement activation, alternative pathway" EXACT [] synonym: "up-regulation of complement activation, alternative pathway" EXACT [] synonym: "upregulation of complement activation, alternative pathway" EXACT [] is_a: GO:0030451 ! regulation of complement activation, alternative pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006957 ! complement activation, alternative pathway relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0045959 name: negative regulation of complement activation, classical pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] synonym: "down regulation of complement activation, classical pathway" EXACT [] synonym: "down-regulation of complement activation, classical pathway" EXACT [] synonym: "downregulation of complement activation, classical pathway" EXACT [] synonym: "inhibition of complement activation, classical pathway" NARROW [] synonym: "negative regulation of complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0002924 ! negative regulation of humoral immune response mediated by circulating immunoglobulin is_a: GO:0030450 ! regulation of complement activation, classical pathway is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006958 ! complement activation, classical pathway relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0045960 name: positive regulation of complement activation, classical pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] synonym: "activation of complement activation, classical pathway" NARROW [] synonym: "positive regulation of complement cascade, classical pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, classical pathway" NARROW [] synonym: "up regulation of complement activation, classical pathway" EXACT [] synonym: "up-regulation of complement activation, classical pathway" EXACT [] synonym: "upregulation of complement activation, classical pathway" EXACT [] is_a: GO:0002925 ! positive regulation of humoral immune response mediated by circulating immunoglobulin is_a: GO:0030450 ! regulation of complement activation, classical pathway is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006958 ! complement activation, classical pathway relationship: positively_regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0045961 name: negative regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [GOC:go_curators] synonym: "down regulation of development, heterochronic" EXACT [] synonym: "down-regulation of development, heterochronic" EXACT [] synonym: "downregulation of development, heterochronic" EXACT [] synonym: "inhibition of development, heterochronic" NARROW [] is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0045962 name: positive regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [GOC:go_curators] synonym: "activation of development, heterochronic" NARROW [] synonym: "stimulation of development, heterochronic" NARROW [] synonym: "up regulation of development, heterochronic" EXACT [] synonym: "up-regulation of development, heterochronic" EXACT [] synonym: "upregulation of development, heterochronic" EXACT [] is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0045963 name: negative regulation of dopamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "down regulation of dopamine metabolic process" EXACT [] synonym: "down-regulation of dopamine metabolic process" EXACT [] synonym: "downregulation of dopamine metabolic process" EXACT [] synonym: "inhibition of dopamine metabolic process" NARROW [] synonym: "negative regulation of dopamine metabolism" EXACT [] is_a: GO:0042053 ! regulation of dopamine metabolic process is_a: GO:0045914 ! negative regulation of catecholamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042417 ! dopamine metabolic process relationship: negatively_regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0045964 name: positive regulation of dopamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] synonym: "activation of dopamine metabolic process" NARROW [] synonym: "positive regulation of dopamine metabolism" EXACT [] synonym: "stimulation of dopamine metabolic process" NARROW [] synonym: "up regulation of dopamine metabolic process" EXACT [] synonym: "up-regulation of dopamine metabolic process" EXACT [] synonym: "upregulation of dopamine metabolic process" EXACT [] is_a: GO:0042053 ! regulation of dopamine metabolic process is_a: GO:0045915 ! positive regulation of catecholamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042417 ! dopamine metabolic process relationship: positively_regulates GO:0042417 ! dopamine metabolic process [Term] id: GO:0045965 name: negative regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] synonym: "down regulation of ecdysteroid metabolic process" EXACT [] synonym: "down-regulation of ecdysteroid metabolic process" EXACT [] synonym: "downregulation of ecdysteroid metabolic process" EXACT [] synonym: "inhibition of ecdysteroid metabolic process" NARROW [] synonym: "negative regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045455 ! ecdysteroid metabolic process relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0045966 name: positive regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] synonym: "activation of ecdysteroid metabolic process" NARROW [] synonym: "positive regulation of ecdysteroid metabolism" EXACT [] synonym: "stimulation of ecdysteroid metabolic process" NARROW [] synonym: "up regulation of ecdysteroid metabolic process" EXACT [] synonym: "up-regulation of ecdysteroid metabolic process" EXACT [] synonym: "upregulation of ecdysteroid metabolic process" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045455 ! ecdysteroid metabolic process relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0045967 name: negative regulation of growth rate namespace: biological_process def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah] comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. synonym: "down regulation of growth rate" EXACT [] synonym: "down-regulation of growth rate" EXACT [] synonym: "downregulation of growth rate" EXACT [] synonym: "inhibition of growth rate" NARROW [] is_a: GO:0040009 ! regulation of growth rate is_a: GO:0045926 ! negative regulation of growth [Term] id: GO:0045968 name: negative regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "downregulation of juvenile hormone biosynthetic process" EXACT [] synonym: "inhibition of juvenile hormone biosynthetic process" NARROW [] synonym: "negative regulation of juvenile hormone anabolism" EXACT [] synonym: "negative regulation of juvenile hormone biosynthesis" EXACT [] synonym: "negative regulation of juvenile hormone formation" EXACT [] synonym: "negative regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0045969 name: positive regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone biosynthetic process" NARROW [] synonym: "positive regulation of juvenile hormone anabolism" EXACT [] synonym: "positive regulation of juvenile hormone biosynthesis" EXACT [] synonym: "positive regulation of juvenile hormone formation" EXACT [] synonym: "positive regulation of juvenile hormone synthesis" EXACT [] synonym: "stimulation of juvenile hormone biosynthetic process" NARROW [] synonym: "up regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT [] synonym: "upregulation of juvenile hormone biosynthetic process" EXACT [] is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0045970 name: negative regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone catabolic process" EXACT [] synonym: "down-regulation of juvenile hormone catabolic process" EXACT [] synonym: "downregulation of juvenile hormone catabolic process" EXACT [] synonym: "inhibition of juvenile hormone catabolic process" NARROW [] synonym: "negative regulation of juvenile hormone breakdown" EXACT [] synonym: "negative regulation of juvenile hormone catabolism" EXACT [] synonym: "negative regulation of juvenile hormone degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006719 ! juvenile hormone catabolic process relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045971 name: positive regulation of juvenile hormone catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone catabolic process" NARROW [] synonym: "positive regulation of juvenile hormone breakdown" EXACT [] synonym: "positive regulation of juvenile hormone catabolism" EXACT [] synonym: "positive regulation of juvenile hormone degradation" EXACT [] synonym: "stimulation of juvenile hormone catabolic process" NARROW [] synonym: "up regulation of juvenile hormone catabolic process" EXACT [] synonym: "up-regulation of juvenile hormone catabolic process" EXACT [] synonym: "upregulation of juvenile hormone catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process is_a: GO:0045952 ! regulation of juvenile hormone catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006719 ! juvenile hormone catabolic process relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process [Term] id: GO:0045972 name: negative regulation of juvenile hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "down regulation of juvenile hormone secretion" EXACT [] synonym: "down-regulation of juvenile hormone secretion" EXACT [] synonym: "downregulation of juvenile hormone secretion" EXACT [] synonym: "inhibition of juvenile hormone secretion" NARROW [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045443 ! juvenile hormone secretion relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0045973 name: positive regulation of juvenile hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] synonym: "activation of juvenile hormone secretion" NARROW [] synonym: "stimulation of juvenile hormone secretion" NARROW [] synonym: "up regulation of juvenile hormone secretion" EXACT [] synonym: "up-regulation of juvenile hormone secretion" EXACT [] synonym: "upregulation of juvenile hormone secretion" EXACT [] is_a: GO:0007558 ! regulation of juvenile hormone secretion is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045443 ! juvenile hormone secretion relationship: positively_regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0045974 name: regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0045975 name: positive regulation of translation, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of mRNA translation, ncRNA-mediated" NARROW [] synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW [] synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT [] synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT [] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0045974 ! regulation of translation, ncRNA-mediated [Term] id: GO:0045976 name: negative regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT [] synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW [] synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0045977 name: positive regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of mitotic cell cycle, embryonic" NARROW [] synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of mitotic cell cycle, embryonic" NARROW [] synonym: "up regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT [] synonym: "upregulation of mitotic cell cycle, embryonic" EXACT [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0045931 ! positive regulation of mitotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0045978 name: negative regulation of nucleoside metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "down regulation of nucleoside metabolic process" EXACT [] synonym: "down-regulation of nucleoside metabolic process" EXACT [] synonym: "downregulation of nucleoside metabolic process" EXACT [] synonym: "inhibition of nucleoside metabolic process" NARROW [] synonym: "negative regulation of nucleoside metabolism" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009116 ! nucleoside metabolic process relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045979 name: positive regulation of nucleoside metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "activation of nucleoside metabolic process" NARROW [] synonym: "positive regulation of nucleoside metabolism" EXACT [] synonym: "stimulation of nucleoside metabolic process" NARROW [] synonym: "up regulation of nucleoside metabolic process" EXACT [] synonym: "up-regulation of nucleoside metabolic process" EXACT [] synonym: "upregulation of nucleoside metabolic process" EXACT [] is_a: GO:0009118 ! regulation of nucleoside metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009116 ! nucleoside metabolic process relationship: positively_regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0045980 name: negative regulation of nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "down regulation of nucleotide metabolic process" EXACT [] synonym: "down-regulation of nucleotide metabolic process" EXACT [] synonym: "downregulation of nucleotide metabolic process" EXACT [] synonym: "inhibition of nucleotide metabolic process" NARROW [] synonym: "negative regulation of nucleotide metabolism" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009117 ! nucleotide metabolic process relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045981 name: positive regulation of nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "activation of nucleotide metabolic process" NARROW [] synonym: "positive regulation of nucleotide metabolism" EXACT [] synonym: "stimulation of nucleotide metabolic process" NARROW [] synonym: "up regulation of nucleotide metabolic process" EXACT [] synonym: "up-regulation of nucleotide metabolic process" EXACT [] synonym: "upregulation of nucleotide metabolic process" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009117 ! nucleotide metabolic process relationship: positively_regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0045982 name: negative regulation of purine nucleobase metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." [GOC:go_curators] synonym: "down regulation of purine base metabolic process" EXACT [] synonym: "down-regulation of purine base metabolic process" EXACT [] synonym: "downregulation of purine base metabolic process" EXACT [] synonym: "inhibition of purine base metabolic process" NARROW [] synonym: "negative regulation of purine base metabolic process" EXACT [GOC:go_curators] synonym: "negative regulation of purine base metabolism" EXACT [] is_a: GO:0006141 ! regulation of purine nucleobase metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006144 ! purine nucleobase metabolic process relationship: negatively_regulates GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0045983 name: positive regulation of purine nucleobase metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] synonym: "activation of purine base metabolic process" NARROW [] synonym: "positive regulation of purine base metabolic process" EXACT [] synonym: "positive regulation of purine base metabolism" EXACT [] synonym: "stimulation of purine base metabolic process" NARROW [] synonym: "up regulation of purine base metabolic process" EXACT [] synonym: "up-regulation of purine base metabolic process" EXACT [] synonym: "upregulation of purine base metabolic process" EXACT [] is_a: GO:0006141 ! regulation of purine nucleobase metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006144 ! purine nucleobase metabolic process relationship: positively_regulates GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0045984 name: negative regulation of pyrimidine nucleobase metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] synonym: "down regulation of pyrimidine base metabolic process" EXACT [] synonym: "down-regulation of pyrimidine base metabolic process" EXACT [] synonym: "downregulation of pyrimidine base metabolic process" EXACT [] synonym: "inhibition of pyrimidine base metabolic process" NARROW [] synonym: "negative regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "negative regulation of pyrimidine base metabolism" EXACT [] is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process relationship: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0045985 name: positive regulation of pyrimidine nucleobase metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] synonym: "activation of pyrimidine base metabolic process" NARROW [] synonym: "positive regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "positive regulation of pyrimidine base metabolism" EXACT [] synonym: "stimulation of pyrimidine base metabolic process" NARROW [] synonym: "up regulation of pyrimidine base metabolic process" EXACT [] synonym: "up-regulation of pyrimidine base metabolic process" EXACT [] synonym: "upregulation of pyrimidine base metabolic process" EXACT [] is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process relationship: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0045986 name: negative regulation of smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of smooth muscle contraction" EXACT [] synonym: "down-regulation of smooth muscle contraction" EXACT [] synonym: "downregulation of smooth muscle contraction" EXACT [] synonym: "inhibition of smooth muscle contraction" NARROW [] synonym: "smooth muscle relaxation" RELATED [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006939 ! smooth muscle contraction relationship: negatively_regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0045987 name: positive regulation of smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "activation of smooth muscle contraction" NARROW [] synonym: "stimulation of smooth muscle contraction" NARROW [] synonym: "up regulation of smooth muscle contraction" EXACT [] synonym: "up-regulation of smooth muscle contraction" EXACT [] synonym: "upregulation of smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006939 ! smooth muscle contraction relationship: positively_regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0045988 name: negative regulation of striated muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "down regulation of striated muscle contraction" EXACT [] synonym: "down-regulation of striated muscle contraction" EXACT [] synonym: "downregulation of striated muscle contraction" EXACT [] synonym: "inhibition of striated muscle contraction" NARROW [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006941 ! striated muscle contraction relationship: negatively_regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0045989 name: positive regulation of striated muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "activation of striated muscle contraction" NARROW [] synonym: "stimulation of striated muscle contraction" NARROW [] synonym: "up regulation of striated muscle contraction" EXACT [] synonym: "up-regulation of striated muscle contraction" EXACT [] synonym: "upregulation of striated muscle contraction" EXACT [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006941 ! striated muscle contraction relationship: positively_regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0045990 name: carbon catabolite regulation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445] synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0031670 ! cellular response to nutrient [Term] id: GO:0045991 name: carbon catabolite activation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:mah, PMID:10559153] synonym: "positive regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009790 ! embryo development relationship: negatively_regulates GO:0009790 ! embryo development [Term] id: GO:0045993 name: negative regulation of translational initiation by iron namespace: biological_process def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation by iron" EXACT [] synonym: "down-regulation of translational initiation by iron" EXACT [] synonym: "downregulation of translational initiation by iron" EXACT [] synonym: "inhibition of translational initiation by iron" NARROW [] is_a: GO:0006447 ! regulation of translational initiation by iron is_a: GO:0045947 ! negative regulation of translational initiation [Term] id: GO:0045994 name: positive regulation of translational initiation by iron namespace: biological_process def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation by iron" NARROW [] synonym: "stimulation of translational initiation by iron" NARROW [] synonym: "up regulation of translational initiation by iron" EXACT [] synonym: "up-regulation of translational initiation by iron" EXACT [] synonym: "upregulation of translational initiation by iron" EXACT [] is_a: GO:0006447 ! regulation of translational initiation by iron is_a: GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009790 ! embryo development relationship: regulates GO:0009790 ! embryo development [Term] id: GO:0045996 name: negative regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators] synonym: "down regulation of transcription by pheromones" EXACT [] synonym: "down-regulation of transcription by pheromones" EXACT [] synonym: "downregulation of transcription by pheromones" EXACT [] synonym: "inhibition of transcription by pheromones" NARROW [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0045997 name: negative regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "down regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "downregulation of ecdysteroid biosynthetic process" EXACT [] synonym: "inhibition of ecdysteroid biosynthetic process" NARROW [] synonym: "negative regulation of ecdysteroid anabolism" EXACT [] synonym: "negative regulation of ecdysteroid biosynthesis" EXACT [] synonym: "negative regulation of ecdysteroid formation" EXACT [] synonym: "negative regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0045998 name: positive regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "activation of ecdysteroid biosynthetic process" NARROW [] synonym: "positive regulation of ecdysteroid anabolism" EXACT [] synonym: "positive regulation of ecdysteroid biosynthesis" EXACT [] synonym: "positive regulation of ecdysteroid formation" EXACT [] synonym: "positive regulation of ecdysteroid synthesis" EXACT [] synonym: "stimulation of ecdysteroid biosynthetic process" NARROW [] synonym: "up regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT [] synonym: "upregulation of ecdysteroid biosynthetic process" EXACT [] is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0045999 name: negative regulation of ecdysteroid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "down regulation of ecdysteroid secretion" EXACT [] synonym: "down-regulation of ecdysteroid secretion" EXACT [] synonym: "downregulation of ecdysteroid secretion" EXACT [] synonym: "inhibition of ecdysteroid secretion" NARROW [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:2000832 ! negative regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045457 ! ecdysteroid secretion relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0046000 name: positive regulation of ecdysteroid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] synonym: "activation of ecdysteroid secretion" NARROW [] synonym: "stimulation of ecdysteroid secretion" NARROW [] synonym: "up regulation of ecdysteroid secretion" EXACT [] synonym: "up-regulation of ecdysteroid secretion" EXACT [] synonym: "upregulation of ecdysteroid secretion" EXACT [] is_a: GO:0007555 ! regulation of ecdysteroid secretion is_a: GO:2000833 ! positive regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045457 ! ecdysteroid secretion relationship: positively_regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0046001 name: negative regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0046002 name: positive regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT [] is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0046003 name: negative regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT [] is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0046004 name: positive regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0046005 name: positive regulation of circadian sleep/wake cycle, REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "positive regulation of REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT [] is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep [Term] id: GO:0046006 name: regulation of activated T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators] synonym: "regulation of activated T lymphocyte proliferation" EXACT [] synonym: "regulation of activated T-cell proliferation" EXACT [] synonym: "regulation of activated T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050798 ! activated T cell proliferation relationship: regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0046007 name: negative regulation of activated T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators] synonym: "down regulation of activated T cell proliferation" EXACT [] synonym: "down-regulation of activated T cell proliferation" EXACT [] synonym: "downregulation of activated T cell proliferation" EXACT [] synonym: "inhibition of activated T cell proliferation" NARROW [] synonym: "negative regulation of activated T lymphocyte proliferation" EXACT [] synonym: "negative regulation of activated T-cell proliferation" EXACT [] synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046006 ! regulation of activated T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050798 ! activated T cell proliferation relationship: negatively_regulates GO:0050798 ! activated T cell proliferation [Term] id: GO:0046008 name: regulation of female receptivity, post-mating namespace: biological_process def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0046009 name: positive regulation of female receptivity, post-mating namespace: biological_process def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] synonym: "activation of female receptivity, post-mating" NARROW [] synonym: "stimulation of female receptivity, post-mating" NARROW [] synonym: "up regulation of female receptivity, post-mating" EXACT [] synonym: "up-regulation of female receptivity, post-mating" EXACT [] synonym: "upregulation of female receptivity, post-mating" EXACT [] is_a: GO:0045925 ! positive regulation of female receptivity is_a: GO:0046008 ! regulation of female receptivity, post-mating [Term] id: GO:0046010 name: positive regulation of circadian sleep/wake cycle, non-REM sleep namespace: biological_process def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators] synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "positive regulation of non-REM sleep" EXACT [] synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW [] synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0046011 name: regulation of oskar mRNA translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0046012 name: positive regulation of oskar mRNA translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators] synonym: "activation of oskar mRNA translation" NARROW [] synonym: "stimulation of oskar mRNA translation" NARROW [] synonym: "up regulation of oskar mRNA translation" EXACT [] synonym: "up-regulation of oskar mRNA translation" EXACT [] synonym: "upregulation of oskar mRNA translation" EXACT [] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0046013 name: regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "regulation of resting T cell proliferation" EXACT [] synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "regulation of T-cell homeostatic proliferation" EXACT [] synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001777 ! T cell homeostatic proliferation relationship: regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0046014 name: negative regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "down regulation of T cell homeostatic proliferation" EXACT [] synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] synonym: "downregulation of T cell homeostatic proliferation" EXACT [] synonym: "inhibition of T cell homeostatic proliferation" NARROW [] synonym: "negative regulation of resting T cell proliferation" EXACT [] synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001777 ! T cell homeostatic proliferation relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation [Term] id: GO:0046015 name: regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] is_a: GO:0006355 ! regulation of transcription, DNA-templated [Term] id: GO:0046016 name: positive regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by glucose" NARROW [] synonym: "stimulation of transcription by glucose" NARROW [] synonym: "up regulation of transcription by glucose" EXACT [] synonym: "up-regulation of transcription by glucose" EXACT [] synonym: "upregulation of transcription by glucose" EXACT [] is_a: GO:0045991 ! carbon catabolite activation of transcription is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0046017 name: obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "mitotic regulation of transcription from Pol I promoter" EXACT [] synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb] synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0046018 name: obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "activation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol I promoter" EXACT [] synonym: "positive regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0046019 name: regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0009373 ! regulation of transcription by pheromones [Term] id: GO:0046020 name: negative regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0045996 ! negative regulation of transcription by pheromones is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones [Term] id: GO:0046021 name: obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "mitotic regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0046022 name: obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "activation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0046023 name: obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "mitotic regulation of transcription from Pol III promoter" EXACT [] synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT [] synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0046024 name: obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "activation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic activation of transcription from Pol III promoter" EXACT [] synonym: "positive regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] synonym: "stimulation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "up regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "up-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "upregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0046025 name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132] synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132] synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132] synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132] xref: EC:2.1.1.132 xref: MetaCyc:2.1.1.132-RXN xref: RHEA:17477 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046026 name: precorrin-4 C11-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133] synonym: "CobM" RELATED [EC:2.1.1.133] synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133] xref: EC:2.1.1.133 xref: MetaCyc:2.1.1.133-RXN xref: RHEA:22012 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046027 name: phospholipid:diacylglycerol acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] synonym: "PDAT activity" EXACT [EC:2.3.1.158] synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] xref: EC:2.3.1.158 xref: MetaCyc:2.3.1.158-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0046028 name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity namespace: molecular_function def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] synonym: "plastocyanin" NARROW [] is_a: GO:0009055 ! electron transfer activity [Term] id: GO:0046029 name: mannitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." [EC:1.1.1.255, RHEA:15029] synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255] synonym: "MTD activity" EXACT [EC:1.1.1.255] synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255] xref: EC:1.1.1.255 xref: KEGG_REACTION:R07135 xref: MetaCyc:1.1.1.255-RXN xref: RHEA:15029 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0046030 name: inositol trisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf] synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW [] synonym: "IP(3) phosphatase activity" EXACT [] synonym: "IP3 phosphatase activity" EXACT [] is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0046031 name: ADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] synonym: "ADP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process [Term] id: GO:0046032 name: ADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] synonym: "ADP breakdown" EXACT [] synonym: "ADP catabolism" EXACT [] synonym: "ADP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0046033 name: AMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators] synonym: "adenylate forming enzyme activity" RELATED [] synonym: "AMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0046034 name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] synonym: "ATP metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0046035 name: CMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators] synonym: "CMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046036 name: CTP metabolic process namespace: biological_process alt_id: GO:0006243 def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators] synonym: "CTP deamination" NARROW [] synonym: "CTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046037 name: GMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators] synonym: "GMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0046038 name: GMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators] synonym: "GMP breakdown" EXACT [] synonym: "GMP catabolism" EXACT [] synonym: "GMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046037 ! GMP metabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0046039 name: GTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators] synonym: "GTP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0046040 name: IMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators] synonym: "IMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0046041 name: ITP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators] synonym: "ITP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0046042 name: ITP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators] synonym: "ITP anabolism" EXACT [] synonym: "ITP biosynthesis" EXACT [] synonym: "ITP formation" EXACT [] synonym: "ITP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0046043 name: TDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators] synonym: "TDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046044 name: TMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators] synonym: "TMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046045 name: TMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators] synonym: "TMP breakdown" EXACT [] synonym: "TMP catabolism" EXACT [] synonym: "TMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0046046 name: TTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators] synonym: "TTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046047 name: TTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators] synonym: "TTP breakdown" EXACT [] synonym: "TTP catabolism" EXACT [] synonym: "TTP degradation" EXACT [] synonym: "TTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0046048 name: UDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators] synonym: "UDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046049 name: UMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators] synonym: "UMP metabolism" EXACT [] is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046050 name: UMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators] synonym: "UMP breakdown" EXACT [] synonym: "UMP catabolism" EXACT [] synonym: "UMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0046051 name: UTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators] synonym: "UTP metabolism" EXACT [] is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046052 name: UTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators] synonym: "UTP breakdown" EXACT [] synonym: "UTP catabolism" EXACT [] synonym: "UTP degradation" EXACT [] synonym: "UTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0046053 name: dAMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] synonym: "dAMP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046054 name: dGMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] synonym: "dGMP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0046055 name: dGMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] synonym: "dGMP breakdown" EXACT [] synonym: "dGMP catabolism" EXACT [] synonym: "dGMP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0046056 name: dADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] synonym: "dADP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046057 name: dADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] synonym: "dADP breakdown" EXACT [] synonym: "dADP catabolism" EXACT [] synonym: "dADP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0046058 name: cAMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators] synonym: "3',5' cAMP metabolic process" EXACT [] synonym: "3',5' cAMP metabolism" EXACT [] synonym: "3',5'-cAMP metabolic process" EXACT [] synonym: "3',5'-cAMP metabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "cAMP generating peptide activity" RELATED [] synonym: "cAMP metabolism" EXACT [] synonym: "cyclic AMP metabolic process" EXACT [] synonym: "cyclic AMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0046059 name: dAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] synonym: "dAMP breakdown" EXACT [] synonym: "dAMP catabolism" EXACT [] synonym: "dAMP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0046060 name: dATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] synonym: "dATP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046061 name: dATP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] synonym: "dATP breakdown" EXACT [] synonym: "dATP catabolism" EXACT [] synonym: "dATP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0046062 name: dCDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators] synonym: "dCDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046063 name: dCMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators] synonym: "dCMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046064 name: dCMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators] synonym: "dCMP anabolism" EXACT [] synonym: "dCMP biosynthesis" EXACT [] synonym: "dCMP formation" EXACT [] synonym: "dCMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0046065 name: dCTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators] synonym: "dCTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046066 name: dGDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] synonym: "dGDP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0046067 name: dGDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] synonym: "dGDP breakdown" EXACT [] synonym: "dGDP catabolism" EXACT [] synonym: "dGDP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0046068 name: cGMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] synonym: "cGMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0046069 name: cGMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] synonym: "cGMP breakdown" EXACT [] synonym: "cGMP catabolism" EXACT [] synonym: "cGMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046068 ! cGMP metabolic process [Term] id: GO:0046070 name: dGTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators] synonym: "dGTP metabolism" EXACT [] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0046071 name: dGTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators] synonym: "dGTP anabolism" EXACT [] synonym: "dGTP biosynthesis" EXACT [] synonym: "dGTP formation" EXACT [] synonym: "dGTP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0046072 name: dTDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators] synonym: "dTDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046073 name: dTMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators] synonym: "dTMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046074 name: dTMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators] synonym: "dTMP breakdown" EXACT [] synonym: "dTMP catabolism" EXACT [] synonym: "dTMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0046075 name: dTTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] synonym: "dTTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046076 name: dTTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] synonym: "dTTP breakdown" EXACT [] synonym: "dTTP catabolism" EXACT [] synonym: "dTTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0046077 name: dUDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators] synonym: "dUDP metabolism" EXACT [] is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046078 name: dUMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators] synonym: "dUMP metabolism" EXACT [] is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046079 name: dUMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators] synonym: "dUMP breakdown" EXACT [] synonym: "dUMP catabolism" EXACT [] synonym: "dUMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0046080 name: dUTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] synonym: "dUTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0046081 name: dUTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] synonym: "dUTP breakdown" EXACT [] synonym: "dUTP catabolism" EXACT [] synonym: "dUTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0046082 name: 5-methylcytosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] synonym: "5-methylcytosine anabolism" EXACT [] synonym: "5-methylcytosine biosynthesis" EXACT [] synonym: "5-methylcytosine formation" EXACT [] synonym: "5-methylcytosine synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019857 ! 5-methylcytosine metabolic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0046083 name: adenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] synonym: "adenine metabolism" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0046084 name: adenine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] synonym: "adenine anabolism" EXACT [] synonym: "adenine biosynthesis" EXACT [] synonym: "adenine formation" EXACT [] synonym: "adenine synthesis" EXACT [] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0046085 name: adenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] synonym: "adenosine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046086 name: adenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] synonym: "adenosine anabolism" EXACT [] synonym: "adenosine biosynthesis" EXACT [] synonym: "adenosine formation" EXACT [] synonym: "adenosine synthesis" EXACT [] is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0046087 name: cytidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] synonym: "cytidine metabolism" EXACT [] is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046088 name: cytidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] synonym: "cytidine anabolism" EXACT [] synonym: "cytidine biosynthesis" EXACT [] synonym: "cytidine formation" EXACT [] synonym: "cytidine synthesis" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process [Term] id: GO:0046089 name: cytosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] synonym: "cytosine anabolism" EXACT [] synonym: "cytosine biosynthesis" EXACT [] synonym: "cytosine formation" EXACT [] synonym: "cytosine synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0046090 name: deoxyadenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyadenosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046091 name: deoxyadenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyadenosine anabolism" EXACT [] synonym: "deoxyadenosine biosynthesis" EXACT [] synonym: "deoxyadenosine formation" EXACT [] synonym: "deoxyadenosine synthesis" EXACT [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0046092 name: deoxycytidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxycytidine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046093 name: deoxycytidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxycytidine anabolism" EXACT [] synonym: "deoxycytidine biosynthesis" EXACT [] synonym: "deoxycytidine formation" EXACT [] synonym: "deoxycytidine synthesis" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046094 name: deoxyinosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] synonym: "deoxyinosine metabolism" EXACT [] is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046095 name: deoxyinosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] synonym: "deoxyinosine anabolism" EXACT [] synonym: "deoxyinosine biosynthesis" EXACT [] synonym: "deoxyinosine formation" EXACT [] synonym: "deoxyinosine synthesis" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process [Term] id: GO:0046096 name: deoxyuridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyuridine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046097 name: deoxyuridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyuridine anabolism" EXACT [] synonym: "deoxyuridine biosynthesis" EXACT [] synonym: "deoxyuridine formation" EXACT [] synonym: "deoxyuridine synthesis" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046098 name: guanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] synonym: "guanine metabolism" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0046099 name: guanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] synonym: "guanine anabolism" EXACT [] synonym: "guanine biosynthesis" EXACT [] synonym: "guanine formation" EXACT [] synonym: "guanine synthesis" EXACT [] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0046100 name: hypoxanthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] synonym: "hypoxanthine metabolism" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0046101 name: hypoxanthine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] synonym: "hypoxanthine anabolism" EXACT [] synonym: "hypoxanthine biosynthesis" EXACT [] synonym: "hypoxanthine formation" EXACT [] synonym: "hypoxanthine synthesis" EXACT [] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0046102 name: inosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] synonym: "inosine metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046103 name: inosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] synonym: "inosine anabolism" EXACT [] synonym: "inosine biosynthesis" EXACT [] synonym: "inosine formation" EXACT [] synonym: "inosine synthesis" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0046104 name: thymidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] synonym: "deoxyribosylthymine metabolic process" EXACT [] synonym: "deoxyribosylthymine metabolism" EXACT [] synonym: "thymidine metabolism" EXACT [] is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0046105 name: thymidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] synonym: "deoxyribosylthymine biosynthesis" EXACT [] synonym: "deoxyribosylthymine biosynthetic process" EXACT [] synonym: "thymidine anabolism" EXACT [] synonym: "thymidine biosynthesis" EXACT [] synonym: "thymidine formation" EXACT [] synonym: "thymidine synthesis" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process [Term] id: GO:0046106 name: thymine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] synonym: "thymine anabolism" EXACT [] synonym: "thymine biosynthesis" EXACT [] synonym: "thymine formation" EXACT [] synonym: "thymine synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0046107 name: uracil biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil anabolism" EXACT [] synonym: "uracil biosynthesis" EXACT [] synonym: "uracil formation" EXACT [] synonym: "uracil synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process is_a: GO:0019860 ! uracil metabolic process [Term] id: GO:0046108 name: uridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] synonym: "uridine metabolism" EXACT [] is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process [Term] id: GO:0046109 name: uridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] synonym: "uridine anabolism" EXACT [] synonym: "uridine biosynthesis" EXACT [] synonym: "uridine formation" EXACT [] synonym: "uridine synthesis" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process [Term] id: GO:0046110 name: xanthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] synonym: "xanthine metabolism" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0046111 name: xanthine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] synonym: "xanthine anabolism" EXACT [] synonym: "xanthine biosynthesis" EXACT [] synonym: "xanthine formation" EXACT [] synonym: "xanthine synthesis" EXACT [] is_a: GO:0009113 ! purine nucleobase biosynthetic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0046112 name: nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0046113 name: nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase breakdown" EXACT [] synonym: "nucleobase catabolism" EXACT [] synonym: "nucleobase degradation" EXACT [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0046114 name: guanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] synonym: "guanosine anabolism" EXACT [] synonym: "guanosine biosynthesis" EXACT [] synonym: "guanosine formation" EXACT [] synonym: "guanosine synthesis" EXACT [] is_a: GO:0008617 ! guanosine metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0046115 name: guanosine catabolic process namespace: biological_process alt_id: GO:0006160 def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] synonym: "guanosine breakdown" EXACT [] synonym: "guanosine catabolism" EXACT [] synonym: "guanosine degradation" EXACT [] synonym: "guanosine phosphorolysis" RELATED [] is_a: GO:0008617 ! guanosine metabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0046116 name: queuosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732] synonym: "queuosine metabolism" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process [Term] id: GO:0046117 name: queuosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732] synonym: "queuosine breakdown" EXACT [] synonym: "queuosine catabolism" EXACT [] synonym: "queuosine degradation" EXACT [] is_a: GO:0042454 ! ribonucleoside catabolic process is_a: GO:0046116 ! queuosine metabolic process [Term] id: GO:0046118 name: 7-methylguanosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] synonym: "7-methylguanosine anabolism" EXACT [] synonym: "7-methylguanosine biosynthesis" EXACT [] synonym: "7-methylguanosine formation" EXACT [] synonym: "7-methylguanosine synthesis" EXACT [] is_a: GO:0008618 ! 7-methylguanosine metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0046119 name: 7-methylguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] synonym: "7-methylguanosine breakdown" EXACT [] synonym: "7-methylguanosine catabolism" EXACT [] synonym: "7-methylguanosine degradation" EXACT [] is_a: GO:0008618 ! 7-methylguanosine metabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0046120 name: deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "deoxyribonucleoside anabolism" EXACT [] synonym: "deoxyribonucleoside biosynthesis" EXACT [] synonym: "deoxyribonucleoside formation" EXACT [] synonym: "deoxyribonucleoside synthesis" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process [Term] id: GO:0046121 name: deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "deoxyribonucleoside breakdown" EXACT [] synonym: "deoxyribonucleoside catabolism" EXACT [] synonym: "deoxyribonucleoside degradation" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process [Term] id: GO:0046122 name: purine deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "purine deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009120 ! deoxyribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0046123 name: purine deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "purine deoxyribonucleoside anabolism" EXACT [] synonym: "purine deoxyribonucleoside biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside formation" EXACT [] synonym: "purine deoxyribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046124 name: purine deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "purine deoxyribonucleoside breakdown" EXACT [] synonym: "purine deoxyribonucleoside catabolism" EXACT [] synonym: "purine deoxyribonucleoside degradation" EXACT [] is_a: GO:0006152 ! purine nucleoside catabolic process is_a: GO:0046121 ! deoxyribonucleoside catabolic process is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0046125 name: pyrimidine deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009120 ! deoxyribonucleoside metabolic process [Term] id: GO:0046126 name: pyrimidine deoxyribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT [] is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0046127 name: pyrimidine deoxyribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside degradation" EXACT [] is_a: GO:0046121 ! deoxyribonucleoside catabolic process is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process [Term] id: GO:0046128 name: purine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "purine ribonucleoside metabolism" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0046129 name: purine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "purine ribonucleoside anabolism" EXACT [] synonym: "purine ribonucleoside biosynthesis" EXACT [] synonym: "purine ribonucleoside formation" EXACT [] synonym: "purine ribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046130 name: purine ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "purine ribonucleoside breakdown" EXACT [] synonym: "purine ribonucleoside catabolism" EXACT [] synonym: "purine ribonucleoside degradation" EXACT [] is_a: GO:0006152 ! purine nucleoside catabolic process is_a: GO:0042454 ! ribonucleoside catabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0046131 name: pyrimidine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "pyrimidine ribonucleoside metabolism" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009119 ! ribonucleoside metabolic process [Term] id: GO:0046132 name: pyrimidine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "pyrimidine ribonucleoside anabolism" EXACT [] synonym: "pyrimidine ribonucleoside biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside formation" EXACT [] synonym: "pyrimidine ribonucleoside synthesis" EXACT [] is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process [Term] id: GO:0046133 name: pyrimidine ribonucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] synonym: "pyrimidine ribonucleoside breakdown" EXACT [] synonym: "pyrimidine ribonucleoside catabolism" EXACT [] synonym: "pyrimidine ribonucleoside degradation" EXACT [] is_a: GO:0042454 ! ribonucleoside catabolic process is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process [Term] id: GO:0046134 name: pyrimidine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "pyrimidine nucleoside anabolism" EXACT [] synonym: "pyrimidine nucleoside biosynthesis" EXACT [] synonym: "pyrimidine nucleoside formation" EXACT [] synonym: "pyrimidine nucleoside synthesis" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0046135 name: pyrimidine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] synonym: "pyrimidine nucleoside breakdown" EXACT [] synonym: "pyrimidine nucleoside catabolism" EXACT [] synonym: "pyrimidine nucleoside degradation" EXACT [] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0046136 name: positive regulation of vitamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "activation of vitamin metabolic process" NARROW [] synonym: "positive regulation of vitamin metabolism" EXACT [] synonym: "stimulation of vitamin metabolic process" NARROW [] synonym: "up regulation of vitamin metabolic process" EXACT [] synonym: "up-regulation of vitamin metabolic process" EXACT [] synonym: "upregulation of vitamin metabolic process" EXACT [] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006766 ! vitamin metabolic process relationship: positively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046137 name: negative regulation of vitamin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "down regulation of vitamin metabolic process" EXACT [] synonym: "down-regulation of vitamin metabolic process" EXACT [] synonym: "downregulation of vitamin metabolic process" EXACT [] synonym: "inhibition of vitamin metabolic process" NARROW [] synonym: "negative regulation of vitamin metabolism" EXACT [] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006766 ! vitamin metabolic process relationship: negatively_regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0046138 name: obsolete coenzyme and prosthetic group biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" EXACT [] synonym: "coenzyme and prosthetic group biosynthetic process" EXACT [] synonym: "coenzyme and prosthetic group formation" EXACT [] synonym: "coenzyme and prosthetic group synthesis" EXACT [] is_obsolete: true consider: GO:0009108 consider: GO:0051191 [Term] id: GO:0046139 name: obsolete coenzyme and prosthetic group catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group breakdown" EXACT [] synonym: "coenzyme and prosthetic group catabolic process" EXACT [] synonym: "coenzyme and prosthetic group catabolism" EXACT [] synonym: "coenzyme and prosthetic group degradation" EXACT [] is_obsolete: true consider: GO:0009109 consider: GO:0051190 [Term] id: GO:0046140 name: corrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] synonym: "corrin anabolism" EXACT [] synonym: "corrin biosynthesis" EXACT [] synonym: "corrin formation" EXACT [] synonym: "corrin synthesis" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0046141 name: corrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] synonym: "corrin breakdown" EXACT [] synonym: "corrin catabolism" EXACT [] synonym: "corrin degradation" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0046142 name: obsolete negative regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0051198 consider: GO:0051201 [Term] id: GO:0046143 name: obsolete positive regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0051197 consider: GO:0051200 [Term] id: GO:0046144 name: D-alanine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai] synonym: "D-alanine family amino acid metabolism" EXACT [] is_a: GO:0006522 ! alanine metabolic process [Term] id: GO:0046145 name: D-alanine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai] synonym: "D-alanine family amino acid anabolism" EXACT [] synonym: "D-alanine family amino acid biosynthesis" EXACT [] synonym: "D-alanine family amino acid formation" EXACT [] synonym: "D-alanine family amino acid synthesis" EXACT [] is_a: GO:0006523 ! alanine biosynthetic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process [Term] id: GO:0046146 name: tetrahydrobiopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [PMID:21871890] synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [GOC:curators] synonym: "tetrahydrobiopterin metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0046147 name: tetrahydrobiopterin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732] synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [Wikipedia:Tetrahydrobiopterin] synonym: "tetrahydrobiopterin breakdown" EXACT [] synonym: "tetrahydrobiopterin catabolism" EXACT [] synonym: "tetrahydrobiopterin degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0046148 name: pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732] synonym: "pigment anabolism" EXACT [] synonym: "pigment biosynthesis" EXACT [] synonym: "pigment formation" EXACT [] synonym: "pigment synthesis" EXACT [] is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046149 name: pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732] synonym: "pigment breakdown" EXACT [] synonym: "pigment catabolism" EXACT [] synonym: "pigment degradation" EXACT [] is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046150 name: melanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732] synonym: "melanin breakdown" EXACT [] synonym: "melanin catabolism" EXACT [] synonym: "melanin degradation" EXACT [] is_a: GO:0006582 ! melanin metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0046151 name: eye pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment breakdown" EXACT [] synonym: "eye pigment catabolism" EXACT [] synonym: "eye pigment degradation" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0046152 name: ommochrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] synonym: "ommochrome metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046158 ! ocellus pigment metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0046153 name: ommochrome catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] synonym: "ommochrome breakdown" EXACT [] synonym: "ommochrome catabolism" EXACT [] synonym: "ommochrome degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046151 ! eye pigment catabolic process is_a: GO:0046152 ! ommochrome metabolic process is_a: GO:0046159 ! ocellus pigment catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046154 name: rhodopsin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] synonym: "rhodopsin metabolism" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0046155 name: rhodopsin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] synonym: "rhodopsin breakdown" EXACT [] synonym: "rhodopsin catabolism" EXACT [] synonym: "rhodopsin degradation" EXACT [] is_a: GO:0044257 ! cellular protein catabolic process is_a: GO:0046151 ! eye pigment catabolic process is_a: GO:0046154 ! rhodopsin metabolic process [Term] id: GO:0046156 name: siroheme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] synonym: "sirohaem metabolic process" EXACT [] synonym: "sirohaem metabolism" EXACT [] synonym: "siroheme metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046157 name: siroheme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] synonym: "sirohaem catabolic process" EXACT [] synonym: "sirohaem catabolism" EXACT [] synonym: "siroheme breakdown" EXACT [] synonym: "siroheme catabolism" EXACT [] synonym: "siroheme degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046156 ! siroheme metabolic process [Term] id: GO:0046158 name: ocellus pigment metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0043474 ! pigment metabolic process involved in pigmentation relationship: part_of GO:0033060 ! ocellus pigmentation [Term] id: GO:0046159 name: ocellus pigment catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment breakdown" EXACT [] synonym: "ocellus pigment catabolism" EXACT [] synonym: "ocellus pigment degradation" EXACT [] is_a: GO:0046149 ! pigment catabolic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0046160 name: heme a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [GOC:curators] synonym: "haem a metabolic process" EXACT [] synonym: "haem a metabolism" EXACT [] synonym: "heme a metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046161 name: heme a catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [GOC:curators] synonym: "haem a catabolic process" EXACT [] synonym: "haem a catabolism" EXACT [] synonym: "heme a breakdown" EXACT [] synonym: "heme a catabolism" EXACT [] synonym: "heme a degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0046162 name: heme c metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] synonym: "haem c metabolic process" EXACT [] synonym: "haem c metabolism" EXACT [] synonym: "heme c metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046163 name: heme c catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] synonym: "haem c catabolic process" EXACT [] synonym: "haem c catabolism" EXACT [] synonym: "heme c breakdown" EXACT [] synonym: "heme c catabolism" EXACT [] synonym: "heme c degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0046164 name: alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol breakdown" EXACT [] synonym: "alcohol catabolism" EXACT [] synonym: "alcohol degradation" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0046166 name: glyceraldehyde-3-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT [] synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT [] synonym: "glyceraldehyde-3-phosphate anabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT [] synonym: "glyceraldehyde-3-phosphate formation" EXACT [] synonym: "glyceraldehyde-3-phosphate synthesis" EXACT [] is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046167 name: glycerol-3-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] synonym: "glycerol-3-phosphate anabolism" EXACT [] synonym: "glycerol-3-phosphate biosynthesis" EXACT [] synonym: "glycerol-3-phosphate formation" EXACT [] synonym: "glycerol-3-phosphate synthesis" EXACT [] is_a: GO:0006072 ! glycerol-3-phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046168 name: glycerol-3-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] synonym: "glycerol-3-phosphate breakdown" EXACT [] synonym: "glycerol-3-phosphate catabolism" EXACT [] synonym: "glycerol-3-phosphate degradation" EXACT [] is_a: GO:0006072 ! glycerol-3-phosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0046169 name: methanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] synonym: "methanol anabolism" EXACT [] synonym: "methanol biosynthesis" EXACT [] synonym: "methanol formation" EXACT [] synonym: "methanol synthesis" EXACT [] is_a: GO:0015945 ! methanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0046170 name: methanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] synonym: "methanol breakdown" EXACT [] synonym: "methanol catabolism" EXACT [] synonym: "methanol degradation" EXACT [] is_a: GO:0015945 ! methanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0046171 name: octanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] synonym: "octanol anabolism" EXACT [] synonym: "octanol biosynthesis" EXACT [] synonym: "octanol formation" EXACT [] synonym: "octanol synthesis" EXACT [] is_a: GO:0006070 ! octanol metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:1903175 ! fatty alcohol biosynthetic process [Term] id: GO:0046172 name: octanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] synonym: "octanol breakdown" EXACT [] synonym: "octanol catabolism" EXACT [] synonym: "octanol degradation" EXACT [] is_a: GO:0006070 ! octanol metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:1903174 ! fatty alcohol catabolic process [Term] id: GO:0046173 name: polyol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191] synonym: "polyhydric alcohol biosynthetic process" EXACT [] synonym: "polyol anabolism" EXACT [] synonym: "polyol biosynthesis" EXACT [] synonym: "polyol formation" EXACT [] synonym: "polyol synthesis" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046174 name: polyol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191] synonym: "polyhydric alcohol catabolic process" EXACT [] synonym: "polyol breakdown" EXACT [] synonym: "polyol catabolism" EXACT [] synonym: "polyol degradation" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0046175 name: aldonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] synonym: "aldonic acid anabolism" EXACT [] synonym: "aldonic acid biosynthesis" EXACT [] synonym: "aldonic acid formation" EXACT [] synonym: "aldonic acid synthesis" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046176 name: aldonic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] synonym: "aldonic acid breakdown" EXACT [] synonym: "aldonic acid catabolism" EXACT [] synonym: "aldonic acid degradation" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046177 name: D-gluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] synonym: "D-gluconate breakdown" EXACT [] synonym: "D-gluconate catabolism" EXACT [] synonym: "D-gluconate degradation" EXACT [] xref: MetaCyc:GLUCONSUPER-PWY is_a: GO:0019521 ! D-gluconate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0046178 name: D-gluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] synonym: "D-gluconate anabolism" EXACT [] synonym: "D-gluconate biosynthesis" EXACT [] synonym: "D-gluconate formation" EXACT [] synonym: "D-gluconate synthesis" EXACT [] is_a: GO:0019521 ! D-gluconate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046179 name: keto-D-gluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] synonym: "keto-D-gluconate anabolism" EXACT [] synonym: "keto-D-gluconate biosynthesis" EXACT [] synonym: "keto-D-gluconate formation" EXACT [] synonym: "keto-D-gluconate synthesis" EXACT [] is_a: GO:0019525 ! keto-D-gluconate metabolic process is_a: GO:0046180 ! ketogluconate biosynthetic process [Term] id: GO:0046180 name: ketogluconate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] synonym: "ketogluconate anabolism" EXACT [] synonym: "ketogluconate biosynthesis" EXACT [] synonym: "ketogluconate formation" EXACT [] synonym: "ketogluconate synthesis" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046181 name: ketogluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] synonym: "ketogluconate breakdown" EXACT [] synonym: "ketogluconate catabolism" EXACT [] synonym: "ketogluconate degradation" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0046182 name: L-idonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators] synonym: "L-idonate anabolism" EXACT [] synonym: "L-idonate biosynthesis" EXACT [] synonym: "L-idonate formation" EXACT [] synonym: "L-idonate synthesis" EXACT [] is_a: GO:0019523 ! L-idonate metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process [Term] id: GO:0046183 name: L-idonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators] synonym: "L-idonate breakdown" EXACT [] synonym: "L-idonate catabolism" EXACT [] synonym: "L-idonate degradation" EXACT [] is_a: GO:0019523 ! L-idonate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0046184 name: aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] synonym: "aldehyde anabolism" EXACT [] synonym: "aldehyde biosynthesis" EXACT [] synonym: "aldehyde formation" EXACT [] synonym: "aldehyde synthesis" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0046185 name: aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] synonym: "aldehyde breakdown" EXACT [] synonym: "aldehyde catabolism" EXACT [] synonym: "aldehyde degradation" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046186 name: acetaldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] synonym: "acetaldehyde anabolism" EXACT [] synonym: "acetaldehyde biosynthesis" EXACT [] synonym: "acetaldehyde formation" EXACT [] synonym: "acetaldehyde synthesis" EXACT [] is_a: GO:0006117 ! acetaldehyde metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0046187 name: acetaldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] synonym: "acetaldehyde breakdown" EXACT [] synonym: "acetaldehyde catabolism" EXACT [] synonym: "acetaldehyde degradation" EXACT [] is_a: GO:0006117 ! acetaldehyde metabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0046188 name: methane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] synonym: "methane breakdown" EXACT [] synonym: "methane catabolism" EXACT [] synonym: "methane degradation" EXACT [] is_a: GO:0015947 ! methane metabolic process is_a: GO:0043448 ! alkane catabolic process [Term] id: GO:0046189 name: phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai] synonym: "phenol-containing compound anabolism" EXACT [] synonym: "phenol-containing compound biosynthesis" EXACT [] synonym: "phenol-containing compound formation" EXACT [] synonym: "phenol-containing compound synthesis" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0046190 name: aerobic phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] synonym: "aerobic phenol-containing compound anabolism" EXACT [] synonym: "aerobic phenol-containing compound biosynthesis" EXACT [] synonym: "aerobic phenol-containing compound formation" EXACT [] synonym: "aerobic phenol-containing compound synthesis" EXACT [] is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046191 name: aerobic phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] synonym: "aerobic phenol-containing compound breakdown" EXACT [] synonym: "aerobic phenol-containing compound catabolism" EXACT [] synonym: "aerobic phenol-containing compound degradation" EXACT [] is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0046192 name: anaerobic phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai] synonym: "anaerobic phenol-containing compound anabolism" EXACT [] synonym: "anaerobic phenol-containing compound biosynthesis" EXACT [] synonym: "anaerobic phenol-containing compound formation" EXACT [] synonym: "anaerobic phenol-containing compound synthesis" EXACT [] is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046193 name: anaerobic phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, GOC:ai] synonym: "anaerobic phenol-containing compound breakdown" EXACT [] synonym: "anaerobic phenol-containing compound catabolism" EXACT [] synonym: "anaerobic phenol-containing compound degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process [Term] id: GO:0046194 name: obsolete pentachlorophenol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai] comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "pentachlorophenol anabolism" EXACT [] synonym: "pentachlorophenol biosynthesis" EXACT [] synonym: "pentachlorophenol biosynthetic process" EXACT [] synonym: "pentachlorophenol formation" EXACT [] synonym: "pentachlorophenol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018961 [Term] id: GO:0046195 name: obsolete 4-nitrophenol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-nitrophenol anabolism" EXACT [] synonym: "4-nitrophenol biosynthesis" EXACT [] synonym: "4-nitrophenol biosynthetic process" EXACT [] synonym: "4-nitrophenol formation" EXACT [] synonym: "4-nitrophenol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018960 [Term] id: GO:0046196 name: 4-nitrophenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] synonym: "4-nitrophenol breakdown" EXACT [] synonym: "4-nitrophenol catabolism" EXACT [] synonym: "4-nitrophenol degradation" EXACT [] is_a: GO:0018960 ! 4-nitrophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0046197 name: orcinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai] synonym: "orcinol anabolism" EXACT [] synonym: "orcinol biosynthesis" EXACT [] synonym: "orcinol formation" EXACT [] synonym: "orcinol synthesis" EXACT [] is_a: GO:0018940 ! orcinol metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0046198 name: obsolete cresol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "cresol anabolism" EXACT [] synonym: "cresol biosynthesis" EXACT [] synonym: "cresol biosynthetic process" EXACT [] synonym: "cresol formation" EXACT [] synonym: "cresol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0042212 [Term] id: GO:0046199 name: cresol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] synonym: "cresol breakdown" EXACT [] synonym: "cresol catabolism" EXACT [] synonym: "cresol degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042212 ! cresol metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046200 name: obsolete m-cresol biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai] comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "m-cresol anabolism" EXACT [] synonym: "m-cresol biosynthesis" EXACT [] synonym: "m-cresol biosynthetic process" EXACT [] synonym: "m-cresol formation" EXACT [] synonym: "m-cresol synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018925 [Term] id: GO:0046201 name: cyanate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai] synonym: "cyanate anabolism" EXACT [] synonym: "cyanate biosynthesis" EXACT [] synonym: "cyanate formation" EXACT [] synonym: "cyanate synthesis" EXACT [] is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0046202 name: cyanide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai] synonym: "cyanide anabolism" EXACT [] synonym: "cyanide biosynthesis" EXACT [] synonym: "cyanide formation" EXACT [] synonym: "cyanide synthesis" EXACT [] is_a: GO:0019499 ! cyanide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0046203 name: spermidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] synonym: "spermidine breakdown" EXACT [] synonym: "spermidine catabolism" EXACT [] synonym: "spermidine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0046204 name: nor-spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] synonym: "nor-spermidine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0046205 name: nor-spermidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] synonym: "nor-spermidine breakdown" EXACT [] synonym: "nor-spermidine catabolism" EXACT [] synonym: "nor-spermidine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0046204 ! nor-spermidine metabolic process [Term] id: GO:0046206 name: trypanothione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] synonym: "trypanothione metabolism" EXACT [] is_a: GO:1901685 ! glutathione derivative metabolic process [Term] id: GO:0046207 name: trypanothione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] synonym: "trypanothione breakdown" EXACT [] synonym: "trypanothione catabolism" EXACT [] synonym: "trypanothione degradation" EXACT [] is_a: GO:0046206 ! trypanothione metabolic process is_a: GO:1901686 ! glutathione derivative catabolic process [Term] id: GO:0046208 name: spermine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [PMID:12141946] synonym: "spermine breakdown" EXACT [] synonym: "spermine catabolism" EXACT [] synonym: "spermine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0008215 ! spermine metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0046209 name: nitric oxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process is_a: GO:2001057 ! reactive nitrogen species metabolic process [Term] id: GO:0046210 name: nitric oxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide breakdown" EXACT [] synonym: "nitric oxide catabolism" EXACT [] synonym: "nitric oxide degradation" EXACT [] is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046209 ! nitric oxide metabolic process [Term] id: GO:0046211 name: (+)-camphor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai] synonym: "(+)-camphor anabolism" EXACT [] synonym: "(+)-camphor biosynthesis" EXACT [] synonym: "(+)-camphor formation" EXACT [] synonym: "(+)-camphor synthesis" EXACT [] is_a: GO:0016099 ! monoterpenoid biosynthetic process is_a: GO:0018882 ! (+)-camphor metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0046212 name: obsolete methyl ethyl ketone biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai] comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "methyl ethyl ketone anabolism" EXACT [] synonym: "methyl ethyl ketone biosynthesis" EXACT [] synonym: "methyl ethyl ketone biosynthetic process" EXACT [] synonym: "methyl ethyl ketone formation" EXACT [] synonym: "methyl ethyl ketone synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018928 [Term] id: GO:0046213 name: methyl ethyl ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai] synonym: "methyl ethyl ketone breakdown" EXACT [] synonym: "methyl ethyl ketone catabolism" EXACT [] synonym: "methyl ethyl ketone degradation" EXACT [] is_a: GO:0018928 ! methyl ethyl ketone metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0046214 name: enterobactin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai] synonym: "enterobactin breakdown" EXACT [] synonym: "enterobactin catabolism" EXACT [] synonym: "enterobactin degradation" EXACT [] is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0046215 ! siderophore catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046215 name: siderophore catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai] synonym: "siderochrome catabolism" NARROW [] synonym: "siderophore breakdown" EXACT [] synonym: "siderophore catabolism" EXACT [] synonym: "siderophore degradation" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process [Term] id: GO:0046216 name: indole phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] synonym: "indole phytoalexin breakdown" EXACT [] synonym: "indole phytoalexin catabolism" EXACT [] synonym: "indole phytoalexin degradation" EXACT [] is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046217 name: indole phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] synonym: "indole phytoalexin metabolism" EXACT [] is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046218 name: indolalkylamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] synonym: "indolalkylamine breakdown" EXACT [] synonym: "indolalkylamine catabolism" EXACT [] synonym: "indolalkylamine degradation" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042436 ! indole-containing compound catabolic process [Term] id: GO:0046219 name: indolalkylamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] synonym: "indolalkylamine anabolism" EXACT [] synonym: "indolalkylamine biosynthesis" EXACT [] synonym: "indolalkylamine formation" EXACT [] synonym: "indolalkylamine synthesis" EXACT [] is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0046220 name: pyridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] synonym: "pyridine anabolism" EXACT [] synonym: "pyridine biosynthesis" EXACT [] synonym: "pyridine formation" EXACT [] synonym: "pyridine synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019507 ! pyridine metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0046221 name: pyridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] synonym: "pyridine breakdown" EXACT [] synonym: "pyridine catabolism" EXACT [] synonym: "pyridine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019507 ! pyridine metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0046222 name: aflatoxin metabolic process namespace: biological_process alt_id: GO:0043389 alt_id: GO:0043390 alt_id: GO:0043391 def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] comment: Merged terms as requested https://github.com/geneontology/go-ontology/issues/18291. synonym: "aflatoxin B metabolic process" NARROW [GOC:mah] synonym: "aflatoxin B1 metabolic process" RELATED [] synonym: "aflatoxin B1 metabolism" RELATED [] synonym: "aflatoxin B2 metabolic process" RELATED [] synonym: "aflatoxin B2 metabolism" RELATED [] synonym: "aflatoxin metabolism" EXACT [] is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process [Term] id: GO:0046223 name: aflatoxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] synonym: "aflatoxin breakdown" EXACT [] synonym: "aflatoxin catabolism" EXACT [] synonym: "aflatoxin degradation" EXACT [] is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046222 ! aflatoxin metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process [Term] id: GO:0046224 name: bacteriocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] synonym: "bacteriocin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0030650 ! peptide antibiotic metabolic process [Term] id: GO:0046225 name: bacteriocin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] synonym: "bacteriocin breakdown" EXACT [] synonym: "bacteriocin catabolism" EXACT [] synonym: "bacteriocin degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0030652 ! peptide antibiotic catabolic process is_a: GO:0046224 ! bacteriocin metabolic process is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0046226 name: coumarin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai] synonym: "coumarin breakdown" EXACT [] synonym: "coumarin catabolism" EXACT [] synonym: "coumarin degradation" EXACT [] is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046227 name: obsolete 2,4,5-trichlorophenoxyacetic acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid biosynthetic process" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018980 [Term] id: GO:0046228 name: 2,4,5-trichlorophenoxyacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT [] is_a: GO:0009852 ! auxin catabolic process is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0046229 name: obsolete 2-aminobenzenesulfonate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2-aminobenzenesulfonate anabolism" EXACT [] synonym: "2-aminobenzenesulfonate biosynthesis" EXACT [] synonym: "2-aminobenzenesulfonate biosynthetic process" EXACT [] synonym: "2-aminobenzenesulfonate formation" EXACT [] synonym: "2-aminobenzenesulfonate synthesis" EXACT [] synonym: "2-aminobenzenesulphonate biosynthesis" EXACT [] synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018868 [Term] id: GO:0046230 name: 2-aminobenzenesulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] synonym: "2-aminobenzenesulfonate breakdown" EXACT [] synonym: "2-aminobenzenesulfonate catabolism" EXACT [] synonym: "2-aminobenzenesulfonate degradation" EXACT [] synonym: "2-aminobenzenesulphonate catabolic process" EXACT [] synonym: "2-aminobenzenesulphonate catabolism" EXACT [] is_a: GO:0009310 ! amine catabolic process is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046231 name: obsolete carbazole biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "carbazole anabolism" EXACT [] synonym: "carbazole biosynthesis" EXACT [] synonym: "carbazole biosynthetic process" EXACT [] synonym: "carbazole formation" EXACT [] synonym: "carbazole synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018884 [Term] id: GO:0046232 name: carbazole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] synonym: "carbazole breakdown" EXACT [] synonym: "carbazole catabolism" EXACT [] synonym: "carbazole degradation" EXACT [] is_a: GO:0018884 ! carbazole metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0046233 name: obsolete 3-hydroxyphenylacetate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "3-hydroxyphenylacetate anabolism" EXACT [] synonym: "3-hydroxyphenylacetate biosynthesis" EXACT [] synonym: "3-hydroxyphenylacetate biosynthetic process" EXACT [] synonym: "3-hydroxyphenylacetate formation" EXACT [] synonym: "3-hydroxyphenylacetate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019609 [Term] id: GO:0046234 name: obsolete fluorene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai] comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "fluorene anabolism" EXACT [] synonym: "fluorene biosynthesis" EXACT [] synonym: "fluorene biosynthetic process" EXACT [] synonym: "fluorene formation" EXACT [] synonym: "fluorene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018917 [Term] id: GO:0046235 name: gallate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai] synonym: "gallate anabolism" EXACT [] synonym: "gallate biosynthesis" EXACT [] synonym: "gallate formation" EXACT [] synonym: "gallate synthesis" EXACT [] synonym: "gallic acid biosynthesis" EXACT [] synonym: "gallic acid biosynthetic process" EXACT [] is_a: GO:0018918 ! gallate metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046236 name: mandelate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai] synonym: "mandelate anabolism" EXACT [] synonym: "mandelate biosynthesis" EXACT [] synonym: "mandelate formation" EXACT [] synonym: "mandelate synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0046237 name: obsolete phenanthrene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "phenanthrene anabolism" EXACT [] synonym: "phenanthrene biosynthesis" EXACT [] synonym: "phenanthrene biosynthetic process" EXACT [] synonym: "phenanthrene formation" EXACT [] synonym: "phenanthrene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018955 [Term] id: GO:0046238 name: obsolete phthalate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai] comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "phthalate anabolism" EXACT [] synonym: "phthalate biosynthesis" EXACT [] synonym: "phthalate biosynthetic process" EXACT [] synonym: "phthalate formation" EXACT [] synonym: "phthalate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018963 [Term] id: GO:0046239 name: phthalate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai] synonym: "phthalate breakdown" EXACT [] synonym: "phthalate catabolism" EXACT [] synonym: "phthalate degradation" EXACT [] is_a: GO:0018963 ! phthalate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046240 name: obsolete xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai] comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "xylene anabolism" EXACT [] synonym: "xylene biosynthesis" EXACT [] synonym: "xylene biosynthetic process" EXACT [] synonym: "xylene formation" EXACT [] synonym: "xylene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018948 [Term] id: GO:0046241 name: obsolete m-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "m-xylene anabolism" EXACT [] synonym: "m-xylene biosynthesis" EXACT [] synonym: "m-xylene biosynthetic process" EXACT [] synonym: "m-xylene formation" EXACT [] synonym: "m-xylene synthesis" EXACT [] synonym: "meta-xylene biosynthesis" EXACT [] synonym: "meta-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018949 [Term] id: GO:0046242 name: obsolete o-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "o-xylene anabolism" EXACT [] synonym: "o-xylene biosynthesis" EXACT [] synonym: "o-xylene biosynthetic process" EXACT [] synonym: "o-xylene formation" EXACT [] synonym: "o-xylene synthesis" EXACT [] synonym: "ortho-xylene biosynthesis" EXACT [] synonym: "ortho-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018950 [Term] id: GO:0046243 name: obsolete p-xylene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai] comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "p-xylene anabolism" EXACT [] synonym: "p-xylene biosynthesis" EXACT [] synonym: "p-xylene biosynthetic process" EXACT [] synonym: "p-xylene formation" EXACT [] synonym: "p-xylene synthesis" EXACT [] synonym: "para-xylene biosynthesis" EXACT [] synonym: "para-xylene biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018951 [Term] id: GO:0046244 name: salicylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai] synonym: "salicylic acid breakdown" EXACT [] synonym: "salicylic acid catabolism" EXACT [] synonym: "salicylic acid degradation" EXACT [] is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046245 name: obsolete styrene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai] comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "styrene anabolism" EXACT [] synonym: "styrene biosynthesis" EXACT [] synonym: "styrene biosynthetic process" EXACT [] synonym: "styrene formation" EXACT [] synonym: "styrene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018966 [Term] id: GO:0046246 name: terpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] synonym: "terpene anabolism" EXACT [] synonym: "terpene biosynthesis" EXACT [] synonym: "terpene formation" EXACT [] synonym: "terpene synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0046247 name: terpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] synonym: "terpene breakdown" EXACT [] synonym: "terpene catabolism" EXACT [] synonym: "terpene degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0046248 name: alpha-pinene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] synonym: "alpha-pinene anabolism" EXACT [] synonym: "alpha-pinene biosynthesis" EXACT [] synonym: "alpha-pinene formation" EXACT [] synonym: "alpha-pinene synthesis" EXACT [] is_a: GO:0018867 ! alpha-pinene metabolic process is_a: GO:0043693 ! monoterpene biosynthetic process [Term] id: GO:0046249 name: alpha-pinene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] synonym: "alpha-pinene breakdown" EXACT [] synonym: "alpha-pinene catabolism" EXACT [] synonym: "alpha-pinene degradation" EXACT [] is_a: GO:0018867 ! alpha-pinene metabolic process is_a: GO:0033074 ! pinene catabolic process [Term] id: GO:0046250 name: limonene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] synonym: "limonene anabolism" EXACT [] synonym: "limonene biosynthesis" EXACT [] synonym: "limonene formation" EXACT [] synonym: "limonene synthesis" EXACT [] is_a: GO:0018923 ! limonene metabolic process is_a: GO:0043693 ! monoterpene biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0046251 name: limonene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] synonym: "limonene breakdown" EXACT [] synonym: "limonene catabolism" EXACT [] synonym: "limonene degradation" EXACT [] is_a: GO:0018923 ! limonene metabolic process is_a: GO:0043694 ! monoterpene catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046252 name: toluene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai, PMID:6508079] comment: This term was reinstated from obsolete. synonym: "toluene anabolism" EXACT [] synonym: "toluene biosynthesis" EXACT [] synonym: "toluene formation" EXACT [] synonym: "toluene synthesis" EXACT [] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0046253 name: anaerobic toluene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai, PMID:8573493] comment: This term was reinstated from obsolete. synonym: "anaerobic toluene anabolism" EXACT [] synonym: "anaerobic toluene biosynthesis" EXACT [] synonym: "anaerobic toluene formation" EXACT [] synonym: "anaerobic toluene synthesis" EXACT [] is_a: GO:0018971 ! anaerobic toluene metabolic process is_a: GO:0046252 ! toluene biosynthetic process [Term] id: GO:0046254 name: anaerobic toluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] synonym: "anaerobic toluene breakdown" EXACT [] synonym: "anaerobic toluene catabolism" EXACT [] synonym: "anaerobic toluene degradation" EXACT [] xref: MetaCyc:PWY-81 is_a: GO:0042203 ! toluene catabolic process [Term] id: GO:0046255 name: obsolete 2,4,6-trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2,4,6-trinitrotoluene anabolism" EXACT [] synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT [] synonym: "2,4,6-trinitrotoluene biosynthetic process" EXACT [] synonym: "2,4,6-trinitrotoluene formation" EXACT [] synonym: "2,4,6-trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018974 [Term] id: GO:0046256 name: 2,4,6-trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai] synonym: "2,4,6-trinitrotoluene breakdown" EXACT [] synonym: "2,4,6-trinitrotoluene catabolism" EXACT [] synonym: "2,4,6-trinitrotoluene degradation" EXACT [] is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process is_a: GO:0046260 ! trinitrotoluene catabolic process [Term] id: GO:0046257 name: obsolete anaerobic 2,4,6-trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene biosynthetic process" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018975 [Term] id: GO:0046258 name: anaerobic 2,4,6-trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT [] synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT [] is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process [Term] id: GO:0046259 name: obsolete trinitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai] comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "trinitrotoluene anabolism" EXACT [] synonym: "trinitrotoluene biosynthesis" EXACT [] synonym: "trinitrotoluene biosynthetic process" EXACT [] synonym: "trinitrotoluene formation" EXACT [] synonym: "trinitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018973 [Term] id: GO:0046260 name: trinitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] synonym: "trinitrotoluene breakdown" EXACT [] synonym: "trinitrotoluene catabolism" EXACT [] synonym: "trinitrotoluene degradation" EXACT [] is_a: GO:0018973 ! trinitrotoluene metabolic process is_a: GO:0046263 ! nitrotoluene catabolic process [Term] id: GO:0046261 name: obsolete 4-nitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-nitrotoluene anabolism" EXACT [] synonym: "4-nitrotoluene biosynthesis" EXACT [] synonym: "4-nitrotoluene biosynthetic process" EXACT [] synonym: "4-nitrotoluene formation" EXACT [] synonym: "4-nitrotoluene synthesis" EXACT [] synonym: "4NT biosynthesis" EXACT [] synonym: "4NT biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0019257 [Term] id: GO:0046262 name: obsolete nitrotoluene biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "nitrotoluene anabolism" EXACT [] synonym: "nitrotoluene biosynthesis" EXACT [] synonym: "nitrotoluene biosynthetic process" EXACT [] synonym: "nitrotoluene formation" EXACT [] synonym: "nitrotoluene synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019326 [Term] id: GO:0046263 name: nitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] synonym: "nitrotoluene breakdown" EXACT [] synonym: "nitrotoluene catabolism" EXACT [] synonym: "nitrotoluene degradation" EXACT [] is_a: GO:0019326 ! nitrotoluene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046264 name: obsolete thiocyanate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai] comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "thiocyanate anabolism" EXACT [] synonym: "thiocyanate biosynthesis" EXACT [] synonym: "thiocyanate biosynthetic process" EXACT [] synonym: "thiocyanate formation" EXACT [] synonym: "thiocyanate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018969 [Term] id: GO:0046265 name: thiocyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai] synonym: "thiocyanate breakdown" EXACT [] synonym: "thiocyanate catabolism" EXACT [] synonym: "thiocyanate degradation" EXACT [] is_a: GO:0018969 ! thiocyanate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046266 name: obsolete triethanolamine biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "triethanolamine anabolism" EXACT [] synonym: "triethanolamine biosynthesis" EXACT [] synonym: "triethanolamine biosynthetic process" EXACT [] synonym: "triethanolamine formation" EXACT [] synonym: "triethanolamine synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018981 [Term] id: GO:0046267 name: triethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] synonym: "triethanolamine breakdown" EXACT [] synonym: "triethanolamine catabolism" EXACT [] synonym: "triethanolamine degradation" EXACT [] is_a: GO:0018981 ! triethanolamine metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0046268 name: obsolete toluene-4-sulfonate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "4-toluenesulfonate biosynthesis" EXACT [] synonym: "4-toluenesulfonate biosynthetic process" EXACT [] synonym: "toluene-4-sulfonate anabolism" EXACT [] synonym: "toluene-4-sulfonate biosynthesis" EXACT [] synonym: "toluene-4-sulfonate biosynthetic process" EXACT [] synonym: "toluene-4-sulfonate formation" EXACT [] synonym: "toluene-4-sulfonate synthesis" EXACT [] synonym: "toluene-4-sulphonate biosynthesis" EXACT [] synonym: "toluene-4-sulphonate biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0018972 [Term] id: GO:0046269 name: toluene-4-sulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] synonym: "4-toluenesulfonate catabolic process" EXACT [] synonym: "4-toluenesulfonate catabolism" EXACT [] synonym: "toluene-4-sulfonate breakdown" EXACT [] synonym: "toluene-4-sulfonate catabolism" EXACT [] synonym: "toluene-4-sulfonate degradation" EXACT [] synonym: "toluene-4-sulphonate catabolic process" EXACT [] synonym: "toluene-4-sulphonate catabolism" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0018972 ! toluene-4-sulfonate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0046270 name: obsolete 4-toluenecarboxylate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "4-toluenecarboxylate anabolism" EXACT [] synonym: "4-toluenecarboxylate biosynthesis" EXACT [] synonym: "4-toluenecarboxylate biosynthetic process" EXACT [] synonym: "4-toluenecarboxylate formation" EXACT [] synonym: "4-toluenecarboxylate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0019611 [Term] id: GO:0046271 name: phenylpropanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai] synonym: "phenylpropanoid breakdown" EXACT [] synonym: "phenylpropanoid catabolism" EXACT [] synonym: "phenylpropanoid degradation" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046272 name: stilbene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai] synonym: "stilbene breakdown" EXACT [] synonym: "stilbene catabolism" EXACT [] synonym: "stilbene degradation" EXACT [] is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046273 name: lignan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] synonym: "lignan breakdown" EXACT [] synonym: "lignan catabolism" EXACT [] synonym: "lignan degradation" EXACT [] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046274 name: lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai] synonym: "lignin breakdown" EXACT [] synonym: "lignin catabolism" EXACT [] synonym: "lignin degradation" EXACT [] is_a: GO:0009808 ! lignin metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046275 name: flavonoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai] synonym: "flavonoid breakdown" EXACT [] synonym: "flavonoid catabolism" EXACT [] synonym: "flavonoid degradation" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046276 name: methylgallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] synonym: "methylgallate breakdown" EXACT [] synonym: "methylgallate catabolism" EXACT [] synonym: "methylgallate degradation" EXACT [] xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY is_a: GO:0019489 ! methylgallate metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046277 name: methylgallate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] synonym: "methylgallate anabolism" EXACT [] synonym: "methylgallate biosynthesis" EXACT [] synonym: "methylgallate formation" EXACT [] synonym: "methylgallate synthesis" EXACT [] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0019489 ! methylgallate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046278 name: 3,4-dihydroxybenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, http://chemfinder.cambridgesoft.com/] synonym: "protocatechuate metabolic process" EXACT [PMID:25072253] synonym: "protocatechuate metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0046279 name: 3,4-dihydroxybenzoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate." [GOC:ai] synonym: "protocatechuate anabolism" EXACT [] synonym: "protocatechuate biosynthesis" EXACT [] synonym: "protocatechuate biosynthetic process" EXACT [PMID:25072253] synonym: "protocatechuate formation" EXACT [] synonym: "protocatechuate synthesis" EXACT [] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046280 name: chalcone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai] synonym: "chalcone breakdown" EXACT [] synonym: "chalcone catabolism" EXACT [] synonym: "chalcone degradation" EXACT [] is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046281 name: cinnamic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai] synonym: "cinnamic acid breakdown" EXACT [] synonym: "cinnamic acid catabolism" EXACT [] synonym: "cinnamic acid degradation" EXACT [] synonym: "cinnamylic acid catabolic process" EXACT [] synonym: "cinnamylic acid catabolism" EXACT [] synonym: "phenylacrylic acid catabolic process" EXACT [] synonym: "phenylacrylic acid catabolism" EXACT [] is_a: GO:0009803 ! cinnamic acid metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046282 name: cinnamic acid ester catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai] synonym: "cinnamic acid ester breakdown" EXACT [] synonym: "cinnamic acid ester catabolism" EXACT [] synonym: "cinnamic acid ester degradation" EXACT [] is_a: GO:0009801 ! cinnamic acid ester metabolic process is_a: GO:0046271 ! phenylpropanoid catabolic process [Term] id: GO:0046283 name: anthocyanin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732] synonym: "anthocyanin metabolic process" EXACT [] synonym: "anthocyanin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0046284 name: anthocyanin-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] synonym: "anthocyanin breakdown" EXACT [] synonym: "anthocyanin catabolic process" EXACT [] synonym: "anthocyanin catabolism" EXACT [] synonym: "anthocyanin degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046149 ! pigment catabolic process is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0046285 name: flavonoid phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] synonym: "flavonoid phytoalexin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046286 name: flavonoid phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "flavonoid phytoalexin breakdown" EXACT [] synonym: "flavonoid phytoalexin catabolism" EXACT [] synonym: "flavonoid phytoalexin degradation" EXACT [] is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046287 name: isoflavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group." [GOC:ai, PMID:15734910] synonym: "isoflavonoid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046288 name: isoflavonoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] synonym: "isoflavonoid breakdown" EXACT [] synonym: "isoflavonoid catabolism" EXACT [] synonym: "isoflavonoid degradation" EXACT [] is_a: GO:0046271 ! phenylpropanoid catabolic process is_a: GO:0046287 ! isoflavonoid metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046289 name: isoflavonoid phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin metabolism" EXACT [] is_a: GO:0046287 ! isoflavonoid metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046290 name: isoflavonoid phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin breakdown" EXACT [] synonym: "isoflavonoid phytoalexin catabolism" EXACT [] synonym: "isoflavonoid phytoalexin degradation" EXACT [] is_a: GO:0046288 ! isoflavonoid catabolic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process is_a: GO:0052316 ! phytoalexin catabolic process [Term] id: GO:0046291 name: obsolete 6-hydroxycineole biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "6-endo-hydroxycineole biosynthesis" EXACT [] synonym: "6-endo-hydroxycineole biosynthetic process" EXACT [] synonym: "6-hydroxycineole anabolism" EXACT [] synonym: "6-hydroxycineole biosynthesis" EXACT [] synonym: "6-hydroxycineole biosynthetic process" EXACT [] synonym: "6-hydroxycineole formation" EXACT [] synonym: "6-hydroxycineole synthesis" EXACT [] synonym: "hydroxycineol biosynthesis" EXACT [] synonym: "hydroxycineol biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0019638 [Term] id: GO:0046292 name: formaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [GOC:ai] synonym: "formaldehyde metabolism" EXACT [] synonym: "methanal metabolic process" EXACT [] synonym: "methanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0046293 name: formaldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] synonym: "formaldehyde anabolism" EXACT [] synonym: "formaldehyde biosynthesis" EXACT [] synonym: "formaldehyde formation" EXACT [] synonym: "formaldehyde synthesis" EXACT [] synonym: "methanal biosynthesis" EXACT [] synonym: "methanal biosynthetic process" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0046294 name: formaldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] synonym: "formaldehyde breakdown" EXACT [] synonym: "formaldehyde catabolism" EXACT [] synonym: "formaldehyde degradation" EXACT [] synonym: "methanal catabolic process" EXACT [] synonym: "methanal catabolism" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046292 ! formaldehyde metabolic process is_a: GO:0110095 ! cellular detoxification of aldehyde [Term] id: GO:0046295 name: glycolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] synonym: "glycolate anabolism" EXACT [] synonym: "glycolate biosynthesis" EXACT [] synonym: "glycolate formation" EXACT [] synonym: "glycolate synthesis" EXACT [] is_a: GO:0009441 ! glycolate metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046296 name: glycolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] synonym: "glycolate breakdown" EXACT [] synonym: "glycolate catabolism" EXACT [] synonym: "glycolate degradation" EXACT [] is_a: GO:0009441 ! glycolate metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046297 name: obsolete 2,4-dichlorobenzoate biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2,4-dichlorobenzoate anabolism" EXACT [] synonym: "2,4-dichlorobenzoate biosynthesis" EXACT [] synonym: "2,4-dichlorobenzoate biosynthetic process" EXACT [] synonym: "2,4-dichlorobenzoate formation" EXACT [] synonym: "2,4-dichlorobenzoate synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018898 [Term] id: GO:0046298 name: 2,4-dichlorobenzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] synonym: "2,4-dichlorobenzoate breakdown" EXACT [] synonym: "2,4-dichlorobenzoate catabolism" EXACT [] synonym: "2,4-dichlorobenzoate degradation" EXACT [] is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0046299 name: obsolete 2,4-dichlorophenoxyacetic acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid biosynthetic process" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018901 [Term] id: GO:0046300 name: 2,4-dichlorophenoxyacetic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT [] is_a: GO:0009852 ! auxin catabolic process is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0046301 name: obsolete 2-chloro-N-isopropylacetanilide biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes. synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT [] synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT [] synonym: "2-chloro-N-isopropylacetanilide biosynthetic process" EXACT [] synonym: "2-chloro-N-isopropylacetanilide formation" EXACT [] synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018889 [Term] id: GO:0046302 name: 2-chloro-N-isopropylacetanilide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT [] synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT [] synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT [] is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0046303 name: obsolete 2-nitropropane biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes. synonym: "2-nitropropane anabolism" EXACT [] synonym: "2-nitropropane biosynthesis" EXACT [] synonym: "2-nitropropane biosynthetic process" EXACT [] synonym: "2-nitropropane formation" EXACT [] synonym: "2-nitropropane synthesis" EXACT [] is_obsolete: true replaced_by: GO:0018938 [Term] id: GO:0046304 name: 2-nitropropane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] synonym: "2-nitropropane breakdown" EXACT [] synonym: "2-nitropropane catabolism" EXACT [] synonym: "2-nitropropane degradation" EXACT [] is_a: GO:0018938 ! 2-nitropropane metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046305 name: alkanesulfonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] synonym: "alkanesulfonate anabolism" EXACT [] synonym: "alkanesulfonate biosynthesis" EXACT [] synonym: "alkanesulfonate formation" EXACT [] synonym: "alkanesulfonate synthesis" EXACT [] synonym: "alkanesulphonate biosynthesis" EXACT [] synonym: "alkanesulphonate biosynthetic process" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0046306 name: alkanesulfonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] synonym: "alkanesulfonate breakdown" EXACT [] synonym: "alkanesulfonate catabolism" EXACT [] synonym: "alkanesulfonate degradation" EXACT [] synonym: "alkanesulphonate catabolic process" EXACT [] synonym: "alkanesulphonate catabolism" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0046307 name: Z-phenylacetaldoxime biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] synonym: "Z-phenylacetaldoxime anabolism" EXACT [] synonym: "Z-phenylacetaldoxime biosynthesis" EXACT [] synonym: "Z-phenylacetaldoxime formation" EXACT [] synonym: "Z-phenylacetaldoxime synthesis" EXACT [] is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0046308 name: Z-phenylacetaldoxime catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] synonym: "Z-phenylacetaldoxime breakdown" EXACT [] synonym: "Z-phenylacetaldoxime catabolism" EXACT [] synonym: "Z-phenylacetaldoxime degradation" EXACT [] is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046309 name: 1,3-dichloro-2-propanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] synonym: "1,3-dichloro-2-propanol anabolism" EXACT [] synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT [] synonym: "1,3-dichloro-2-propanol formation" EXACT [] synonym: "1,3-dichloro-2-propanol synthesis" EXACT [] is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0046310 name: 1,3-dichloro-2-propanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] synonym: "1,3-dichloro-2-propanol breakdown" EXACT [] synonym: "1,3-dichloro-2-propanol catabolism" EXACT [] synonym: "1,3-dichloro-2-propanol degradation" EXACT [] is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044109 ! cellular alcohol catabolic process [Term] id: GO:0046311 name: prenylcysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] synonym: "prenylcysteine anabolism" EXACT [] synonym: "prenylcysteine biosynthesis" EXACT [] synonym: "prenylcysteine formation" EXACT [] synonym: "prenylcysteine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0030329 ! prenylcysteine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0046312 name: phosphoarginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] synonym: "phosphoarginine anabolism" EXACT [] synonym: "phosphoarginine biosynthesis" EXACT [] synonym: "phosphoarginine formation" EXACT [] synonym: "phosphoarginine synthesis" EXACT [] is_a: GO:0006604 ! phosphoarginine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0046313 name: phosphoarginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] synonym: "phosphoarginine breakdown" EXACT [] synonym: "phosphoarginine catabolism" EXACT [] synonym: "phosphoarginine degradation" EXACT [] is_a: GO:0006604 ! phosphoarginine metabolic process is_a: GO:0042397 ! phosphagen catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0046314 name: phosphocreatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] synonym: "phosphocreatine anabolism" EXACT [] synonym: "phosphocreatine biosynthesis" EXACT [] synonym: "phosphocreatine formation" EXACT [] synonym: "phosphocreatine synthesis" EXACT [] is_a: GO:0006603 ! phosphocreatine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process [Term] id: GO:0046315 name: phosphocreatine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] synonym: "phosphocreatine breakdown" EXACT [] synonym: "phosphocreatine catabolism" EXACT [] synonym: "phosphocreatine degradation" EXACT [] is_a: GO:0006603 ! phosphocreatine metabolic process is_a: GO:0042397 ! phosphagen catabolic process [Term] id: GO:0046316 name: gluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.12, RHEA:19433] synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12] synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12] synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12] xref: EC:2.7.1.12 xref: KEGG_REACTION:R01737 xref: MetaCyc:GLUCONOKIN-RXN xref: RHEA:19433 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0046317 name: regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of glucosylceramide anabolism" EXACT [] synonym: "regulation of glucosylceramide biosynthesis" EXACT [] synonym: "regulation of glucosylceramide formation" EXACT [] synonym: "regulation of glucosylceramide synthesis" EXACT [] is_a: GO:2000303 ! regulation of ceramide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006679 ! glucosylceramide biosynthetic process relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046318 name: negative regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "down regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "downregulation of glucosylceramide biosynthetic process" EXACT [] synonym: "inhibition of glucosylceramide biosynthetic process" NARROW [] synonym: "negative regulation of glucosylceramide anabolism" EXACT [] synonym: "negative regulation of glucosylceramide biosynthesis" EXACT [] synonym: "negative regulation of glucosylceramide formation" EXACT [] synonym: "negative regulation of glucosylceramide synthesis" EXACT [] is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046319 name: positive regulation of glucosylceramide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] synonym: "activation of glucosylceramide biosynthetic process" NARROW [] synonym: "positive regulation of glucosylceramide anabolism" EXACT [] synonym: "positive regulation of glucosylceramide biosynthesis" EXACT [] synonym: "positive regulation of glucosylceramide formation" EXACT [] synonym: "positive regulation of glucosylceramide synthesis" EXACT [] synonym: "stimulation of glucosylceramide biosynthetic process" NARROW [] synonym: "up regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT [] synonym: "upregulation of glucosylceramide biosynthetic process" EXACT [] is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process is_a: GO:2000304 ! positive regulation of ceramide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process [Term] id: GO:0046320 name: regulation of fatty acid oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai] is_a: GO:0019217 ! regulation of fatty acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019395 ! fatty acid oxidation relationship: regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046321 name: positive regulation of fatty acid oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai] synonym: "activation of fatty acid oxidation" NARROW [] synonym: "stimulation of fatty acid oxidation" NARROW [] synonym: "up regulation of fatty acid oxidation" EXACT [] synonym: "up-regulation of fatty acid oxidation" EXACT [] synonym: "upregulation of fatty acid oxidation" EXACT [] is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019395 ! fatty acid oxidation relationship: positively_regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046322 name: negative regulation of fatty acid oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai] synonym: "down regulation of fatty acid oxidation" EXACT [] synonym: "down-regulation of fatty acid oxidation" EXACT [] synonym: "downregulation of fatty acid oxidation" EXACT [] synonym: "inhibition of fatty acid oxidation" NARROW [] is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019395 ! fatty acid oxidation relationship: negatively_regulates GO:0019395 ! fatty acid oxidation [Term] id: GO:0046323 name: glucose import namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Glucose_uptake is_a: GO:1904659 ! glucose transmembrane transport [Term] id: GO:0046324 name: regulation of glucose import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010827 ! regulation of glucose transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046323 ! glucose import relationship: regulates GO:0046323 ! glucose import [Term] id: GO:0046325 name: negative regulation of glucose import namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] synonym: "down regulation of glucose import" EXACT [] synonym: "down-regulation of glucose import" EXACT [] synonym: "downregulation of glucose import" EXACT [] synonym: "inhibition of glucose import" NARROW [] synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010829 ! negative regulation of glucose transmembrane transport is_a: GO:0046324 ! regulation of glucose import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046323 ! glucose import relationship: negatively_regulates GO:0046323 ! glucose import [Term] id: GO:0046326 name: positive regulation of glucose import namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of glucose import" NARROW [] synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of glucose import" NARROW [] synonym: "up regulation of glucose import" EXACT [] synonym: "up-regulation of glucose import" EXACT [] synonym: "upregulation of glucose import" EXACT [] is_a: GO:0010828 ! positive regulation of glucose transmembrane transport is_a: GO:0046324 ! regulation of glucose import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046323 ! glucose import relationship: positively_regulates GO:0046323 ! glucose import [Term] id: GO:0046327 name: glycerol biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai] synonym: "glycerol anabolism from pyruvate" EXACT [] synonym: "glycerol formation from pyruvate" EXACT [] synonym: "glycerol synthesis from pyruvate" EXACT [] synonym: "glyceroneogenesis" EXACT [] is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006114 ! glycerol biosynthetic process relationship: part_of GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0046328 name: regulation of JNK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "regulation of SAPK cascade" BROAD [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007254 ! JNK cascade relationship: regulates GO:0007254 ! JNK cascade [Term] id: GO:0046329 name: negative regulation of JNK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "down regulation of JNK cascade" EXACT [] synonym: "down-regulation of JNK cascade" EXACT [] synonym: "downregulation of JNK cascade" EXACT [] synonym: "inhibition of JNK cascade" NARROW [] is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade is_a: GO:0046328 ! regulation of JNK cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007254 ! JNK cascade relationship: negatively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046330 name: positive regulation of JNK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] synonym: "activation of JNK cascade" NARROW [] synonym: "stimulation of JNK cascade" NARROW [] synonym: "up regulation of JNK cascade" EXACT [] synonym: "up-regulation of JNK cascade" EXACT [] synonym: "upregulation of JNK cascade" EXACT [] is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade is_a: GO:0046328 ! regulation of JNK cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007254 ! JNK cascade relationship: positively_regulates GO:0007254 ! JNK cascade [Term] id: GO:0046331 name: lateral inhibition namespace: biological_process def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment [Term] id: GO:0046332 name: SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SMAD signaling protein." [GOC:ai] is_a: GO:0005515 ! protein binding [Term] id: GO:0046333 name: octopamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] synonym: "octopamine metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0046334 name: octopamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] synonym: "octopamine breakdown" EXACT [] synonym: "octopamine catabolism" EXACT [] synonym: "octopamine degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0046335 name: ethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] synonym: "ethanolamine anabolism" EXACT [] synonym: "ethanolamine biosynthesis" EXACT [] synonym: "ethanolamine formation" EXACT [] synonym: "ethanolamine synthesis" EXACT [] is_a: GO:0006580 ! ethanolamine metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process [Term] id: GO:0046336 name: ethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] synonym: "ethanolamine breakdown" EXACT [] synonym: "ethanolamine catabolism" EXACT [] synonym: "ethanolamine degradation" EXACT [] is_a: GO:0006580 ! ethanolamine metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0046337 name: phosphatidylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732] synonym: "phosphatidylethanolamine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046338 name: phosphatidylethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] synonym: "phosphatidylethanolamine breakdown" EXACT [] synonym: "phosphatidylethanolamine catabolism" EXACT [] synonym: "phosphatidylethanolamine degradation" EXACT [] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0046339 name: diacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335] synonym: "diacylglycerol metabolism" EXACT [] synonym: "diglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0046340 name: diacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312] synonym: "diacylglycerol breakdown" EXACT [] synonym: "diacylglycerol catabolism" EXACT [] synonym: "diacylglycerol degradation" EXACT [] synonym: "diglyceride catabolism" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0046341 name: CDP-diacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [PMID:24533860] synonym: "CDP-diacylglycerol metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046342 name: CDP-diacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:6147353] synonym: "CDP-diacylglycerol breakdown" EXACT [] synonym: "CDP-diacylglycerol catabolism" EXACT [] synonym: "CDP-diacylglycerol degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0046343 name: streptomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [PMID:2111804] synonym: "streptomycin metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0046344 name: ecdysteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] synonym: "ecdysteroid breakdown" EXACT [] synonym: "ecdysteroid catabolism" EXACT [] synonym: "ecdysteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0046345 name: abscisic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai] synonym: "abscisic acid breakdown" EXACT [] synonym: "abscisic acid catabolism" EXACT [] synonym: "abscisic acid degradation" EXACT [] is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0043290 ! apocarotenoid catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046346 name: mannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:25166, GOC:curators] synonym: "mannosamine breakdown" EXACT [] synonym: "mannosamine catabolism" EXACT [] synonym: "mannosamine degradation" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0046347 name: mannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators] synonym: "mannosamine anabolism" EXACT [] synonym: "mannosamine biosynthesis" EXACT [] synonym: "mannosamine formation" EXACT [] synonym: "mannosamine synthesis" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0046348 name: amino sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators] synonym: "amino sugar breakdown" EXACT [] synonym: "amino sugar catabolism" EXACT [] synonym: "amino sugar degradation" EXACT [] synonym: "aminosaccharide catabolic process" EXACT [] synonym: "aminosaccharide catabolism" EXACT [] xref: MIPS_funcat:01.05.01.01.04 is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0046349 name: amino sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators] synonym: "amino sugar anabolism" EXACT [] synonym: "amino sugar biosynthesis" EXACT [] synonym: "amino sugar formation" EXACT [] synonym: "amino sugar synthesis" EXACT [] synonym: "aminosaccharide biosynthesis" EXACT [] synonym: "aminosaccharide biosynthetic process" EXACT [] xref: MIPS_funcat:01.05.01.03.04 is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046350 name: galactosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] synonym: "galactosaminoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0046351 name: disaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] synonym: "disaccharide anabolism" EXACT [] synonym: "disaccharide biosynthesis" EXACT [] synonym: "disaccharide formation" EXACT [] synonym: "disaccharide synthesis" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process [Term] id: GO:0046352 name: disaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] synonym: "disaccharide breakdown" EXACT [] synonym: "disaccharide catabolism" EXACT [] synonym: "disaccharide degradation" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0046353 name: aminoglycoside 3-N-acetyltransferase activity namespace: molecular_function alt_id: GO:0016991 def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb] synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81] synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60] synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60] synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60] synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81] synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT [] synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60] xref: EC:2.3.1.60 xref: EC:2.3.1.81 xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN xref: MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0046354 name: mannan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732] synonym: "mannan anabolism" EXACT [] synonym: "mannan biosynthesis" EXACT [] synonym: "mannan formation" EXACT [] synonym: "mannan synthesis" EXACT [] is_a: GO:0010412 ! mannan metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0046355 name: mannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732] synonym: "mannan breakdown" EXACT [] synonym: "mannan catabolism" EXACT [] synonym: "mannan degradation" EXACT [] is_a: GO:0010412 ! mannan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0044347 ! cell wall polysaccharide catabolic process [Term] id: GO:0046356 name: acetyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai] synonym: "acetyl-CoA breakdown" EXACT [] synonym: "acetyl-CoA catabolism" EXACT [] synonym: "acetyl-CoA degradation" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0046357 name: galactarate biosynthetic process namespace: biological_process alt_id: GO:0042872 def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [GOC:pr, ISBN:0198506732] synonym: "D-galactarate anabolism" RELATED [] synonym: "D-galactarate biosynthesis" RELATED [] synonym: "D-galactarate biosynthetic process" RELATED [] synonym: "D-galactarate formation" RELATED [] synonym: "D-galactarate synthesis" RELATED [] synonym: "galactarate anabolism" EXACT [] synonym: "galactarate biosynthesis" EXACT [] synonym: "galactarate formation" EXACT [] synonym: "galactarate synthesis" EXACT [] is_a: GO:0019578 ! aldaric acid biosynthetic process is_a: GO:0019580 ! galactarate metabolic process [Term] id: GO:0046358 name: butyrate biosynthetic process namespace: biological_process alt_id: GO:0043439 def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732] synonym: "butanoic acid anabolism" EXACT [] synonym: "butanoic acid biosynthesis" EXACT [] synonym: "butanoic acid biosynthetic process" EXACT [] synonym: "butanoic acid formation" EXACT [] synonym: "butanoic acid synthesis" EXACT [] synonym: "butyrate anabolism" EXACT [] synonym: "butyrate biosynthesis" EXACT [] synonym: "butyrate formation" EXACT [] synonym: "butyrate synthesis" EXACT [] is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0046359 name: butyrate catabolic process namespace: biological_process alt_id: GO:0043440 def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732] synonym: "butanoic acid breakdown" EXACT [] synonym: "butanoic acid catabolic process" EXACT [] synonym: "butanoic acid catabolism" EXACT [] synonym: "butanoic acid degradation" EXACT [] synonym: "butyrate breakdown" EXACT [] synonym: "butyrate catabolism" EXACT [] synonym: "butyrate degradation" EXACT [] is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0019626 ! short-chain fatty acid catabolic process [Term] id: GO:0046360 name: 2-oxobutyrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732] synonym: "2-oxobutyrate anabolism" EXACT [] synonym: "2-oxobutyrate biosynthesis" EXACT [] synonym: "2-oxobutyrate formation" EXACT [] synonym: "2-oxobutyrate synthesis" EXACT [] synonym: "alpha-ketobutyrate biosynthesis" EXACT [] synonym: "alpha-ketobutyrate biosynthetic process" EXACT [] is_a: GO:0046361 ! 2-oxobutyrate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0046361 name: 2-oxobutyrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [http://chemfinder.cambridgesoft.com/, ISBN:0198506732] synonym: "2-oxobutyrate metabolism" EXACT [] synonym: "alpha-ketobutyrate metabolic process" EXACT [] synonym: "alpha-ketobutyrate metabolism" EXACT [] is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0046362 name: ribitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732] synonym: "ribitol anabolism" EXACT [] synonym: "ribitol biosynthesis" EXACT [] synonym: "ribitol formation" EXACT [] synonym: "ribitol synthesis" EXACT [] is_a: GO:0019349 ! ribitol metabolic process is_a: GO:0019526 ! pentitol biosynthetic process [Term] id: GO:0046363 name: ribitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732] synonym: "ribitol breakdown" EXACT [] synonym: "ribitol catabolism" EXACT [] synonym: "ribitol degradation" EXACT [] is_a: GO:0019349 ! ribitol metabolic process is_a: GO:0019527 ! pentitol catabolic process [Term] id: GO:0046364 name: monosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide anabolism" EXACT [] synonym: "monosaccharide biosynthesis" EXACT [] synonym: "monosaccharide formation" EXACT [] synonym: "monosaccharide synthesis" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0046365 name: monosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] synonym: "monosaccharide breakdown" EXACT [] synonym: "monosaccharide catabolism" EXACT [] synonym: "monosaccharide degradation" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0046366 name: allose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] synonym: "allose anabolism" EXACT [] synonym: "allose biosynthesis" EXACT [] synonym: "allose formation" EXACT [] synonym: "allose synthesis" EXACT [] is_a: GO:0019313 ! allose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046367 name: allose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] synonym: "allose breakdown" EXACT [] synonym: "allose catabolism" EXACT [] synonym: "allose degradation" EXACT [] is_a: GO:0019313 ! allose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0046368 name: GDP-L-fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-L-fucose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046369 name: galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732] synonym: "galactose anabolism" EXACT [] synonym: "galactose biosynthesis" EXACT [] synonym: "galactose formation" EXACT [] synonym: "galactose synthesis" EXACT [] is_a: GO:0006012 ! galactose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046370 name: fructose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] synonym: "fructose anabolism" EXACT [] synonym: "fructose biosynthesis" EXACT [] synonym: "fructose formation" EXACT [] synonym: "fructose synthesis" EXACT [] is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0046371 name: dTDP-mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-mannose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046372 name: D-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-arabinose metabolism" EXACT [] is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0046373 name: L-arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-arabinose metabolism" EXACT [] is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0046374 name: teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732] synonym: "teichoic acid metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0046375 name: K antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732] synonym: "K antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0046376 name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0046377 name: colanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html] synonym: "colanic acid metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0046378 name: enterobacterial common antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] synonym: "enterobacterial common antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0046379 name: extracellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai] synonym: "extracellular polysaccharide metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046380 name: N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] synonym: "N-acetylneuraminate anabolism" EXACT [] synonym: "N-acetylneuraminate biosynthesis" EXACT [] synonym: "N-acetylneuraminate formation" EXACT [] synonym: "N-acetylneuraminate synthesis" EXACT [] is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0046381 name: CMP-N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] synonym: "CMP-N-acetylneuraminate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046382 name: GDP-D-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-D-rhamnose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046383 name: dTDP-rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-rhamnose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0046384 name: 2-deoxyribose 1-phosphate metabolic process namespace: biological_process alt_id: GO:0046388 def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732] synonym: "2-deoxyribose 1-phosphate metabolism" EXACT [] synonym: "deoxyribose 1-phosphate metabolic process" EXACT [] synonym: "deoxyribose 1-phosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046385 name: deoxyribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] synonym: "deoxyribose phosphate anabolism" EXACT [] synonym: "deoxyribose phosphate biosynthesis" EXACT [] synonym: "deoxyribose phosphate formation" EXACT [] synonym: "deoxyribose phosphate synthesis" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046386 name: deoxyribose phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] synonym: "deoxyribose phosphate breakdown" EXACT [] synonym: "deoxyribose phosphate catabolism" EXACT [] synonym: "deoxyribose phosphate degradation" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0046387 name: deoxyribose 1,5-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046389 name: deoxyribose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai] synonym: "deoxyribose 5-phosphate metabolism" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0046390 name: ribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate anabolism" EXACT [] synonym: "ribose phosphate biosynthesis" EXACT [] synonym: "ribose phosphate formation" EXACT [] synonym: "ribose phosphate synthesis" EXACT [] is_a: GO:0019693 ! ribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046391 name: 5-phosphoribose 1-diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT [] synonym: "PRPP metabolic process" EXACT [] xref: MetaCyc:PRPP-PWY is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0046392 name: galactarate catabolic process namespace: biological_process alt_id: GO:0019582 def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai, GOC:pr] synonym: "D-galactarate breakdown" RELATED [] synonym: "D-galactarate catabolic process" RELATED [] synonym: "D-galactarate catabolism" RELATED [] synonym: "D-galactarate degradation" RELATED [] synonym: "galactarate breakdown" EXACT [] synonym: "galactarate catabolism" EXACT [] synonym: "galactarate degradation" EXACT [] xref: MetaCyc:GALACTARDEG-PWY is_a: GO:0019579 ! aldaric acid catabolic process is_a: GO:0019580 ! galactarate metabolic process [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046396 name: D-galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-galacturonate metabolism" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process [Term] id: GO:0046397 name: galacturonate catabolic process namespace: biological_process alt_id: GO:0019587 def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai] synonym: "galacturonate breakdown" EXACT [] synonym: "galacturonate catabolism" EXACT [] synonym: "galacturonate degradation" EXACT [] is_a: GO:0019586 ! galacturonate metabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0046398 name: UDP-glucuronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucuronate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046399 name: glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai] synonym: "glucuronate anabolism" EXACT [] synonym: "glucuronate biosynthesis" EXACT [] synonym: "glucuronate formation" EXACT [] synonym: "glucuronate synthesis" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0046400 name: keto-3-deoxy-D-manno-octulosonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [GOC:ai, ISBN:0198506732] synonym: "KDO metabolic process" EXACT [GOC:mah] synonym: "KDO metabolism" EXACT [GOC:mah] synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046401 name: lipopolysaccharide core region metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732] synonym: "lipopolysaccharide core region metabolism" EXACT [] synonym: "LPS core region metabolic process" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process [Term] id: GO:0046402 name: O antigen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732] synonym: "O antigen metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0046403 name: polynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32] synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] xref: EC:3.1.3.32 xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN xref: Reactome:R-HSA-5649705 "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)" is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098506 ! polynucleotide 3' dephosphorylation [Term] id: GO:0046404 name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent DNA kinase activity" EXACT [] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.78 xref: KEGG_REACTION:R03840 xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity [Term] id: GO:0046405 name: glycerol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109] synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30] synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30] xref: EC:4.2.1.30 xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN xref: RHEA:19765 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0046406 name: magnesium protoporphyrin IX methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester." [EC:2.1.1.11, RHEA:17809] synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT [] synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] xref: EC:2.1.1.11 xref: KEGG_REACTION:R04237 xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN xref: RHEA:17809 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046408 name: chlorophyll synthetase activity namespace: molecular_function alt_id: GO:0043787 def: "Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, RHEA:17317] synonym: "chlorophyll synthase activity" EXACT [] synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT [] xref: EC:2.5.1.62 xref: KEGG_REACTION:R06284 xref: MetaCyc:RXN1F-66 xref: RHEA:17317 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0046409 name: p-coumarate 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+." [PMID:11429408, PMID:11891223] synonym: "cytochrome P450 CYP98A3" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0046410 name: obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959] comment: This term was made obsolete because it was derived from an EC entry (2.5.1.64) that has since been split into two entries. synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity" EXACT [] is_obsolete: true consider: GO:0070204 consider: GO:0070205 [Term] id: GO:0046411 name: 2-keto-3-deoxygluconate transmembrane transport namespace: biological_process def: "The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] synonym: "2-keto-3-deoxygluconate transport" RELATED [] is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:0042873 ! aldonate transmembrane transport [Term] id: GO:0046412 name: phenylmercury acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] synonym: "phenylmercury acetate metabolism" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0046413 name: organomercury catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] synonym: "organomercury breakdown" EXACT [] synonym: "organomercury catabolism" EXACT [] synonym: "organomercury degradation" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046414 name: organomercury biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] synonym: "organomercury anabolism" EXACT [] synonym: "organomercury biosynthesis" EXACT [] synonym: "organomercury formation" EXACT [] synonym: "organomercury synthesis" EXACT [] is_a: GO:0018941 ! organomercury metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0046415 name: urate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732] synonym: "urate metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0046416 name: D-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] synonym: "D-amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0046417 name: chorismate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732] synonym: "chorismate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046418 name: nopaline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai] synonym: "nopaline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0046419 name: octopine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai] synonym: "octopine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046421 name: methylisocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30, RHEA:16809] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30] synonym: "2-methylisocitrate lyase activity" EXACT [] synonym: "MICL" RELATED [EC:4.1.3.30] xref: EC:4.1.3.30 xref: KEGG_REACTION:R00409 xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN xref: RHEA:16809 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0046422 name: violaxanthin de-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.23.5.1, GOC:ai, ISBN:0471331309] synonym: "VDE" RELATED [EC:1.23.5.1] synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.23.5.1] xref: EC:1.23.5.1 xref: RHEA:32371 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0046423 name: allene-oxide cyclase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6, RHEA:22592] synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6] xref: EC:5.3.99.6 xref: KEGG_REACTION:R03402 xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN xref: RHEA:22592 is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0046424 name: ferulate 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351] xref: MetaCyc:RXN-1121 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0046425 name: regulation of receptor signaling pathway via JAK-STAT namespace: biological_process alt_id: GO:0007262 alt_id: GO:2000364 def: "Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT." [GOC:bf] comment: Merged regulation of STAT import into nucleus into regulation of JAK-STAT cascade, see https://github.com/geneontology/go-ontology/issues/15268 and STAT import https://github.com/geneontology/go-ontology/issues/13686 synonym: "regulation of STAT protein import into nucleus" NARROW [] synonym: "regulation of STAT protein nuclear translocation" NARROW [GOC:obol] synonym: "STAT protein import into nucleus" NARROW [] is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007259 ! receptor signaling pathway via JAK-STAT relationship: regulates GO:0007259 ! receptor signaling pathway via JAK-STAT [Term] id: GO:0046426 name: negative regulation of receptor signaling pathway via JAK-STAT namespace: biological_process alt_id: GO:2000365 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT." [GOC:bf] synonym: "down regulation of JAK-STAT cascade" EXACT [] synonym: "down-regulation of JAK-STAT cascade" EXACT [] synonym: "downregulation of JAK-STAT cascade" EXACT [] synonym: "inhibition of JAK-STAT cascade" NARROW [] synonym: "negative regulation of STAT protein import into nucleus" NARROW [] synonym: "negative regulation of STAT protein nuclear translocation" NARROW [GOC:obol] is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT is_a: GO:1904893 ! negative regulation of receptor signaling pathway via STAT intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT relationship: negatively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT [Term] id: GO:0046427 name: positive regulation of receptor signaling pathway via JAK-STAT namespace: biological_process alt_id: GO:2000366 def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] synonym: "activation of JAK-STAT cascade" NARROW [] synonym: "positive regulation of STAT protein import into nucleus" NARROW [] synonym: "positive regulation of STAT protein nuclear translocation" NARROW [GOC:obol] synonym: "stimulation of JAK-STAT cascade" NARROW [] synonym: "up regulation of JAK-STAT cascade" EXACT [] synonym: "up-regulation of JAK-STAT cascade" EXACT [] synonym: "upregulation of JAK-STAT cascade" EXACT [] is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT is_a: GO:1904894 ! positive regulation of receptor signaling pathway via STAT intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT relationship: positively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT [Term] id: GO:0046428 name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2." [MetaCyc:DMK-RXN] synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:DMK-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0046429 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431] synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity" EXACT systematic_synonym [EC:1.17.7.1] synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" EXACT [EC:1.17.7.1] synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] xref: EC:1.17.7.1 xref: KEGG_REACTION:R08689 xref: MetaCyc:RXN0-882 is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor [Term] id: GO:0046430 name: non-phosphorylated glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai] synonym: "non-phosphorylated glucose metabolism" EXACT [] is_a: GO:0006006 ! glucose metabolic process [Term] id: GO:0046431 name: (R)-4-hydroxymandelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732] synonym: "(R)-4-hydroxymandelate metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0046432 name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process [Term] id: GO:0046433 name: 2-aminoethylphosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130] synonym: "2-aminoethylphosphonate metabolism" EXACT [] synonym: "2-phosphonoethylamine metabolic process" EXACT [] synonym: "2-phosphonoethylamine metabolism" EXACT [] synonym: "ciliatine metabolic process" EXACT [] synonym: "ciliatine metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0046434 name: organophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] synonym: "organophosphate breakdown" EXACT [] synonym: "organophosphate catabolism" EXACT [] synonym: "organophosphate degradation" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046435 name: 3-(3-hydroxy)phenylpropionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0046436 name: D-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [GOC:ai, GOC:jsg] synonym: "D-alanine metabolism" EXACT [] xref: MIPS_funcat:01.01.11.06 is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046437 name: D-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] synonym: "D-amino acid anabolism" EXACT [] synonym: "D-amino acid biosynthesis" EXACT [] synonym: "D-amino acid formation" EXACT [] synonym: "D-amino acid synthesis" EXACT [] is_a: GO:0046416 ! D-amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0046438 name: D-cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai] synonym: "D-cysteine metabolism" EXACT [] is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046439 name: L-cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-cysteine metabolism" EXACT [] is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0046440 name: L-lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-lysine metabolism" EXACT [] is_a: GO:0006553 ! lysine metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0046441 name: D-lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-lysine metabolism" EXACT [] is_a: GO:0006553 ! lysine metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0046442 name: aerobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] synonym: "aerobactin metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0046443 name: FAD metabolic process namespace: biological_process def: "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide." [PMID:20822113] synonym: "FAD metabolism" EXACT [] synonym: "oxidized flavin adenine dinucleotide metabolic process" EXACT [] synonym: "oxidized flavin adenine dinucleotide metabolism" EXACT [] synonym: "oxidized flavin-adenine dinucleotide metabolic process" EXACT [] synonym: "oxidized flavin-adenine dinucleotide metabolism" EXACT [] is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0046444 name: FMN metabolic process namespace: biological_process def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, PMID:20822113] synonym: "FMN metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0046445 name: benzyl isoquinoline alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732] synonym: "benzyl isoquinoline alkaloid metabolism" EXACT [] is_a: GO:0033076 ! isoquinoline alkaloid metabolic process [Term] id: GO:0046446 name: purine alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] synonym: "purine alkaloid metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0046447 name: terpenoid indole alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] synonym: "terpenoid indole alkaloid metabolism" EXACT [] is_a: GO:0035834 ! indole alkaloid metabolic process [Term] id: GO:0046448 name: tropane alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732] synonym: "tropane alkaloid metabolism" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0046449 name: creatinine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732] synonym: "creatinine metabolism" EXACT [] is_a: GO:0072338 ! cellular lactam metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0046450 name: dethiobiotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732] synonym: "desthiobiotin metabolic process" EXACT [] synonym: "desthiobiotin metabolism" EXACT [] synonym: "dethiobiotin metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0046451 name: diaminopimelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732] synonym: "diaminopimelate metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046452 name: dihydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732] synonym: "dihydrofolate metabolism" EXACT [] synonym: "dihydrofolate reduction" NARROW [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046453 name: dipyrrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] synonym: "dipyrrin metabolism" EXACT [] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0046454 name: dimethylsilanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai] synonym: "dimethylsilanediol metabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0046455 name: organosilicon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai] synonym: "organosilicon breakdown" EXACT [] synonym: "organosilicon catabolism" EXACT [] synonym: "organosilicon degradation" EXACT [] synonym: "organosilicone catabolic process" EXACT [] synonym: "organosilicone catabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0046456 name: icosanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732] synonym: "eicosanoid biosynthesis" EXACT [] synonym: "eicosanoid biosynthetic process" EXACT [] synonym: "icosanoid anabolism" EXACT [] synonym: "icosanoid biosynthesis" EXACT [] synonym: "icosanoid formation" EXACT [] synonym: "icosanoid synthesis" EXACT [] xref: MIPS_funcat:01.20.05.09 xref: Wikipedia:Eicosanoid is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process [Term] id: GO:0046457 name: prostanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai] synonym: "prostanoid anabolism" EXACT [] synonym: "prostanoid biosynthesis" EXACT [] synonym: "prostanoid formation" EXACT [] synonym: "prostanoid synthesis" EXACT [] xref: Wikipedia:Prostanoid#Biosynthesis is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0006692 ! prostanoid metabolic process is_a: GO:0046456 ! icosanoid biosynthetic process [Term] id: GO:0046458 name: hexadecanal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] synonym: "hexadecanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0046459 name: short-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids with a chain length of less than C6." [Wikipedia:Fatty_acid_metabolism] synonym: "short-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0046460 name: neutral lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] synonym: "neutral lipid anabolism" EXACT [] synonym: "neutral lipid biosynthesis" EXACT [] synonym: "neutral lipid formation" EXACT [] synonym: "neutral lipid synthesis" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046461 name: neutral lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] synonym: "neutral lipid breakdown" EXACT [] synonym: "neutral lipid catabolism" EXACT [] synonym: "neutral lipid degradation" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0046462 name: monoacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732] synonym: "monoacylglycerol metabolism" EXACT [] synonym: "monoglyceride metabolic process" EXACT [] synonym: "monoglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0046463 name: acylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] synonym: "acylglycerol anabolism" EXACT [] synonym: "acylglycerol biosynthesis" EXACT [] synonym: "acylglycerol formation" EXACT [] synonym: "acylglycerol synthesis" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process is_a: GO:0045017 ! glycerolipid biosynthetic process is_a: GO:0046460 ! neutral lipid biosynthetic process [Term] id: GO:0046464 name: acylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] synonym: "acylglycerol breakdown" EXACT [] synonym: "acylglycerol catabolism" EXACT [] synonym: "acylglycerol degradation" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process is_a: GO:0046461 ! neutral lipid catabolic process is_a: GO:0046503 ! glycerolipid catabolic process [Term] id: GO:0046465 name: dolichyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732] synonym: "dolichyl diphosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process [Term] id: GO:0046466 name: membrane lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid breakdown" EXACT [] synonym: "membrane lipid catabolism" EXACT [] synonym: "membrane lipid degradation" EXACT [] synonym: "membrane lipid peroxidation" BROAD [GOC:tb] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0046467 name: membrane lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid anabolism" EXACT [] synonym: "membrane lipid biosynthesis" EXACT [] synonym: "membrane lipid formation" EXACT [] synonym: "membrane lipid synthesis" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0046468 name: phosphatidyl-N-monomethylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk] synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT [] synonym: "PMME metabolic process" EXACT [] synonym: "PMME metabolism" EXACT [] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process [Term] id: GO:0046469 name: platelet activating factor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF metabolic process" EXACT [] synonym: "PAF metabolism" EXACT [] synonym: "platelet activating factor metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0046470 name: phosphatidylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732] synonym: "phosphatidylcholine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0046471 name: phosphatidylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732] synonym: "phosphatidylglycerol metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046473 name: phosphatidic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732] synonym: "phosphatidic acid metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046474 name: glycerophospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] synonym: "glycerophospholipid anabolism" EXACT [] synonym: "glycerophospholipid biosynthesis" EXACT [] synonym: "glycerophospholipid formation" EXACT [] synonym: "glycerophospholipid synthesis" EXACT [] synonym: "phosphoglyceride biosynthesis" EXACT [] synonym: "phosphoglyceride biosynthetic process" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0045017 ! glycerolipid biosynthetic process [Term] id: GO:0046475 name: glycerophospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] synonym: "glycerophospholipid breakdown" EXACT [] synonym: "glycerophospholipid catabolism" EXACT [] synonym: "glycerophospholipid degradation" EXACT [] synonym: "phosphoglyceride catabolic process" EXACT [] synonym: "phosphoglyceride catabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0046503 ! glycerolipid catabolic process [Term] id: GO:0046476 name: glycosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] synonym: "glycosylceramide anabolism" EXACT [] synonym: "glycosylceramide biosynthesis" EXACT [] synonym: "glycosylceramide formation" EXACT [] synonym: "glycosylceramide synthesis" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0046477 name: glycosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] synonym: "glycosylceramide breakdown" EXACT [] synonym: "glycosylceramide catabolism" EXACT [] synonym: "glycosylceramide degradation" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process is_a: GO:0046514 ! ceramide catabolic process [Term] id: GO:0046478 name: lactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732] synonym: "lactosylceramide metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0046479 name: glycosphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732] synonym: "glycosphingolipid breakdown" EXACT [] synonym: "glycosphingolipid catabolism" EXACT [] synonym: "glycosphingolipid degradation" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0046480 name: galactolipid galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184] synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184] synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184] synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184] synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT [] synonym: "GGGT activity" EXACT [EC:2.4.1.184] synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184] xref: EC:2.4.1.184 xref: MetaCyc:RXN-1226 xref: RHEA:15921 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0046481 name: digalactosyldiacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.241, RHEA:10520] synonym: "DGD1" NARROW [] synonym: "DGD2" NARROW [] synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241] synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241] synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT [] xref: EC:2.4.1.241 xref: KEGG_REACTION:R04469 xref: MetaCyc:RXN-1225 xref: RHEA:10520 xref: Wikipedia:Digalactosyldiacylglycerol_synthase is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0046482 name: para-aminobenzoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, PMID:11377864, PMID:11960743] synonym: "4-aminobenzoic acid metabolic process" EXACT [] synonym: "4-aminobenzoic acid metabolism" EXACT [] synonym: "p-aminobenzoic acid metabolic process" EXACT [] synonym: "p-aminobenzoic acid metabolism" EXACT [] synonym: "PABA metabolic process" EXACT [] synonym: "PABA metabolism" EXACT [] synonym: "para-aminobenzoic acid metabolism" EXACT [] synonym: "vitamin Bx metabolic process" EXACT [] synonym: "vitamin Bx metabolism" EXACT [] is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732] subset: goslim_pir synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0046484 name: oxazole or thiazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators] synonym: "oxazole or thiazole metabolism" EXACT [] is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046485 name: ether lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732, PMID:15337120] synonym: "ether lipid metabolism" EXACT [] synonym: "plasmalogen metabolic process" NARROW [] xref: Wikipedia:Ether_lipid is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0046486 name: glycerolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569] synonym: "glycerolipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0046487 name: glyoxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] synonym: "glyoxylate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0046488 name: phosphatidylinositol metabolic process namespace: biological_process alt_id: GO:0030384 def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] synonym: "phosphatidylinositol metabolism" EXACT [] synonym: "phosphoinositide metabolic process" EXACT [] synonym: "phosphoinositide metabolism" EXACT [] synonym: "PtdIns metabolic process" EXACT [] synonym: "PtdIns metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0046490 name: isopentenyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732] subset: goslim_pir synonym: "IPP metabolic process" EXACT [] synonym: "IPP metabolism" EXACT [] synonym: "isopentenyl diphosphate metabolism" EXACT [] synonym: "isopentenyl pyrophosphate metabolic process" EXACT [] synonym: "isopentenyl pyrophosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process [Term] id: GO:0046491 name: L-methylmalonyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-methylmalonyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0046492 name: heme b metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25, MetaCyc:PROTOHEME] synonym: "haem b metabolic process" EXACT [] synonym: "haem b metabolism" EXACT [] synonym: "heme b metabolism" EXACT [] synonym: "protoheme metabolic process" EXACT [] synonym: "protoheme metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0046493 name: lipid A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004] synonym: "lipid A metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:1901269 ! lipooligosaccharide metabolic process [Term] id: GO:0046494 name: rhizobactin 1021 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] synonym: "rhizobactin 1021 metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process [Term] id: GO:0046495 name: nicotinamide riboside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] synonym: "N-ribosylnicotinamide metabolic process" EXACT [] synonym: "nicotinamide riboside metabolism" EXACT [] is_a: GO:0070637 ! pyridine nucleoside metabolic process [Term] id: GO:0046496 name: nicotinamide nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] synonym: "nicotinamide nucleotide metabolism" EXACT [] is_a: GO:0019362 ! pyridine nucleotide metabolic process [Term] id: GO:0046497 name: nicotinate nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732] synonym: "nicotinate nucleotide metabolism" EXACT [] is_a: GO:0019362 ! pyridine nucleotide metabolic process [Term] id: GO:0046498 name: S-adenosylhomocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732] synonym: "S-adenosylhomocysteine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0046499 name: S-adenosylmethioninamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] synonym: "S-adenosylmethioninamine metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0046500 name: S-adenosylmethionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] synonym: "S-adenosyl methionine metabolic process" EXACT [] synonym: "S-adenosyl methionine metabolism" EXACT [] synonym: "S-adenosylmethionine metabolism" EXACT [] synonym: "SAM metabolic process" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0046501 name: protoporphyrinogen IX metabolic process namespace: biological_process def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732] comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'. synonym: "protoporphyrinogen IX metabolism" EXACT [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process [Term] id: GO:0046502 name: uroporphyrinogen III metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai] synonym: "uroporphyrinogen III metabolism" EXACT [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046503 name: glycerolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] synonym: "glycerolipid breakdown" EXACT [] synonym: "glycerolipid catabolism" EXACT [] synonym: "glycerolipid degradation" EXACT [] is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0046504 name: glycerol ether biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai] synonym: "glycerol ether anabolism" EXACT [] synonym: "glycerol ether biosynthesis" EXACT [] synonym: "glycerol ether formation" EXACT [] synonym: "glycerol ether synthesis" EXACT [] is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0046505 name: sulfolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] synonym: "sulfolipid metabolism" EXACT [] synonym: "sulpholipid metabolic process" EXACT [] synonym: "sulpholipid metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0046506 name: sulfolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] synonym: "sulfolipid anabolism" EXACT [] synonym: "sulfolipid biosynthesis" EXACT [] synonym: "sulfolipid formation" EXACT [] synonym: "sulfolipid synthesis" EXACT [] synonym: "sulpholipid biosynthesis" EXACT [] synonym: "sulpholipid biosynthetic process" EXACT [] xref: AraCyc:PWYQT-4427 is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046505 ! sulfolipid metabolic process [Term] id: GO:0046507 name: UDPsulfoquinovose synthase activity namespace: molecular_function def: "Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose." [EC:3.13.1.1, RHEA:13197] synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT [] synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1] synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1] synonym: "UDPsulphoquinovose synthase activity" EXACT [] xref: EC:3.13.1.1 xref: KEGG_REACTION:R05775 xref: MetaCyc:RXN-1223 xref: RHEA:13197 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0046508 name: hydrolase activity, acting on carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT [] xref: EC:3.13 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0046509 name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.46, RHEA:14945] synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46] synonym: "1beta-MGDG" RELATED [EC:2.4.1.46] synonym: "MGDG synthase activity" EXACT [] synonym: "monogalactosyldiacylglycerol synthase activity" EXACT [] synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] xref: EC:2.4.1.46 xref: KEGG_REACTION:R02691 xref: MetaCyc:2.4.1.46-RXN xref: RHEA:14945 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0046510 name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224] synonym: "sulfolipid synthase" BROAD [] synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] xref: MetaCyc:RXN-1224 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0046511 name: sphinganine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine biosynthesis" EXACT [] synonym: "dihydrosphingosine biosynthetic process" EXACT [] synonym: "sphinganine anabolism" EXACT [] synonym: "sphinganine biosynthesis" EXACT [] synonym: "sphinganine formation" EXACT [] synonym: "sphinganine synthesis" EXACT [] is_a: GO:0006667 ! sphinganine metabolic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0046512 name: sphingosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732] synonym: "sphingosine anabolism" EXACT [] synonym: "sphingosine biosynthesis" EXACT [] synonym: "sphingosine formation" EXACT [] synonym: "sphingosine synthesis" EXACT [] is_a: GO:0006670 ! sphingosine metabolic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process [Term] id: GO:0046513 name: ceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai] synonym: "ceramide anabolism" EXACT [] synonym: "ceramide biosynthesis" EXACT [] synonym: "ceramide formation" EXACT [] synonym: "ceramide synthesis" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0046514 name: ceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai] synonym: "ceramide breakdown" EXACT [] synonym: "ceramide catabolism" EXACT [] synonym: "ceramide degradation" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0046516 name: hypusine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai] synonym: "hypusine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0046517 name: octamethylcyclotetrasiloxane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] synonym: "octamethylcyclotetrasiloxane breakdown" EXACT [] synonym: "octamethylcyclotetrasiloxane catabolism" EXACT [] synonym: "octamethylcyclotetrasiloxane degradation" EXACT [] is_a: GO:0046455 ! organosilicon catabolic process is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0046518 name: octamethylcyclotetrasiloxane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] synonym: "octamethylcyclotetrasiloxane metabolism" EXACT [] is_a: GO:0018945 ! organosilicon metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046519 name: sphingoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] synonym: "sphingoid base metabolic process" EXACT [] synonym: "sphingoid base metabolism" EXACT [] synonym: "sphingoid metabolism" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0046520 name: sphingoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] synonym: "sphingoid anabolism" EXACT [] synonym: "sphingoid biosynthesis" EXACT [] synonym: "sphingoid formation" EXACT [] synonym: "sphingoid synthesis" EXACT [] is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0046521 name: sphingoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] synonym: "sphingoid breakdown" EXACT [] synonym: "sphingoid catabolism" EXACT [] synonym: "sphingoid degradation" EXACT [] is_a: GO:0030149 ! sphingolipid catabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0046522 name: S-methyl-5-thioribose kinase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.100, RHEA:22312] synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100] synonym: "5-methylthioribose kinase activity" EXACT [] synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100] synonym: "MTR kinase activity" EXACT [EC:2.7.1.100] xref: EC:2.7.1.100 xref: KEGG_REACTION:R04143 xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN xref: RHEA:22312 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0046523 name: S-methyl-5-thioribose-1-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19989] synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23] synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT [] synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23] synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] xref: EC:5.3.1.23 xref: KEGG_REACTION:R04420 xref: MetaCyc:5.3.1.23-RXN xref: Reactome:R-HSA-1237096 "Methylthio-ribose-P = Methylthio-ribulose-P" xref: Reactome:R-HSA-1299507 "Methylthio-ribulose-P = Methylthio-ribose-P" xref: RHEA:19989 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0046524 name: sucrose-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14] synonym: "SPS" RELATED [EC:2.4.1.14] synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14] synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] xref: EC:2.4.1.14 xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN xref: RHEA:22172 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0046525 name: xylosylprotein 4-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133] synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133] synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT [] synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] xref: EC:2.4.1.133 xref: MetaCyc:2.4.1.133-RXN xref: Reactome:R-HSA-1889981 "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker" xref: Reactome:R-HSA-3560804 "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker" is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0046526 name: D-xylulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH." [EC:1.1.1.9, RHEA:20433] synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9] xref: EC:1.1.1.9 xref: KEGG_REACTION:R01896 xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN xref: Reactome:R-HSA-5662471 "SORD tetramer oxidizes xylitol to D-xylulose" xref: RHEA:20433 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0046527 name: glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] xref: EC:2.4.1 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0046528 name: imaginal disc fusion namespace: biological_process def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0046529 name: imaginal disc fusion, thorax closure namespace: biological_process def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0046528 ! imaginal disc fusion [Term] id: GO:0046530 name: photoreceptor cell differentiation namespace: biological_process alt_id: GO:0007467 def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0046532 name: regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045673 def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046530 ! photoreceptor cell differentiation relationship: regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046533 name: negative regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045674 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "down regulation of photoreceptor cell differentiation" EXACT [] synonym: "down regulation of photoreceptor differentiation" EXACT [] synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] synonym: "down-regulation of photoreceptor differentiation" EXACT [] synonym: "downregulation of photoreceptor cell differentiation" EXACT [] synonym: "downregulation of photoreceptor differentiation" EXACT [] synonym: "inhibition of photoreceptor cell differentiation" NARROW [] synonym: "inhibition of photoreceptor differentiation" NARROW [] synonym: "negative regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046530 ! photoreceptor cell differentiation relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046534 name: positive regulation of photoreceptor cell differentiation namespace: biological_process alt_id: GO:0045675 def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "activation of photoreceptor cell differentiation" NARROW [] synonym: "activation of photoreceptor differentiation" NARROW [] synonym: "positive regulation of photoreceptor differentiation" EXACT [] synonym: "stimulation of photoreceptor cell differentiation" NARROW [] synonym: "stimulation of photoreceptor differentiation" NARROW [] synonym: "up regulation of photoreceptor cell differentiation" EXACT [] synonym: "up regulation of photoreceptor differentiation" EXACT [] synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] synonym: "up-regulation of photoreceptor differentiation" EXACT [] synonym: "upregulation of photoreceptor cell differentiation" EXACT [] synonym: "upregulation of photoreceptor differentiation" EXACT [] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046530 ! photoreceptor cell differentiation relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046535 name: detection of chemical stimulus involved in sensory perception of umami taste namespace: biological_process def: "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, GOC:dos, PMID:11894099] synonym: "perception of umami taste, detection of chemical stimulus" EXACT [] synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT [] synonym: "sensory detection of umami taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT [] synonym: "sensory transduction of umami taste" EXACT [] synonym: "umami taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050917 ! sensory perception of umami taste relationship: part_of GO:0050917 ! sensory perception of umami taste [Term] id: GO:0046536 name: dosage compensation complex namespace: cellular_component def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000803 ! sex chromosome relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0046537 name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] synonym: "PGAM-i" RELATED [EC:5.4.2.1] is_a: GO:0004619 ! phosphoglycerate mutase activity [Term] id: GO:0046538 name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1] synonym: "PGAM-d" RELATED [EC:5.4.2.1] is_a: GO:0004619 ! phosphoglycerate mutase activity [Term] id: GO:0046539 name: histamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.8, RHEA:19301] synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8] synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8] synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8] xref: EC:2.1.1.8 xref: KEGG_REACTION:R02155 xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175993 "HNMT transfers CH3 group from AdoMet to Hist" xref: RHEA:19301 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046540 name: U4/U6 x U5 tri-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:pr, PMID:11867543] synonym: "U4/U6.U5 snRNP complex" EXACT [] is_a: GO:0097526 ! spliceosomal tri-snRNP complex relationship: has_part GO:0005682 ! U5 snRNP relationship: has_part GO:0071001 ! U4/U6 snRNP [Term] id: GO:0046541 name: saliva secretion namespace: biological_process def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836] synonym: "salivation" EXACT [] xref: Wikipedia:Salivation is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0046542 name: obsolete alpha-factor export namespace: biological_process def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai] comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process. synonym: "alpha-factor export" EXACT [] is_obsolete: true consider: GO:0015833 [Term] id: GO:0046543 name: development of secondary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0045136 ! development of secondary sexual characteristics [Term] id: GO:0046544 name: development of secondary male sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] is_a: GO:0045136 ! development of secondary sexual characteristics relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0046545 name: development of primary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0046546 name: development of primary male sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0046547 name: trans-aconitate 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.145, RHEA:22200] synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145] xref: EC:2.1.1.145 xref: KEGG_REACTION:R05764 xref: MetaCyc:2.1.1.145-RXN xref: RHEA:22200 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0046548 name: retinal rod cell development namespace: biological_process def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0060221 ! retinal rod cell differentiation [Term] id: GO:0046549 name: retinal cone cell development namespace: biological_process def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0042670 ! retinal cone cell differentiation [Term] id: GO:0046550 name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine namespace: biological_process def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT [] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT [] synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT [] xref: RESID:AA0328 is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0046551 name: retinal cone cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883] is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment relationship: part_of GO:0042670 ! retinal cone cell differentiation [Term] id: GO:0046552 name: photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0046530 ! photoreceptor cell differentiation [Term] id: GO:0046553 name: D-malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate." [EC:1.1.1.83, RHEA:18365] synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83] synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83] synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83] synonym: "D-malic enzyme" RELATED [EC:1.1.1.83] xref: EC:1.1.1.83 xref: KEGG_REACTION:R00215 xref: MetaCyc:1.1.1.83-RXN xref: RHEA:18365 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046554 name: malate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82] synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82, KEGG_REACTION:R00343] synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82] synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82] synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82] xref: EC:1.1.1.82 xref: KEGG_REACTION:R00343 xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:10824 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046555 name: acetylxylan esterase activity namespace: molecular_function def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72] xref: EC:3.1.1.72 xref: MetaCyc:3.1.1.72-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0046556 name: alpha-L-arabinofuranosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf] synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55] synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "alpha-N-arabinofuranosidase activity" RELATED [] synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55] synonym: "arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55] synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT [] xref: EC:3.2.1.55 xref: MetaCyc:3.2.1.55-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046557 name: glucan endo-1,6-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans." [EC:3.2.1.75] synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75] synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75] synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT [] synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75] synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] xref: EC:3.2.1.75 xref: MetaCyc:3.2.1.75-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0046558 name: arabinan endo-1,5-alpha-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans." [EC:3.2.1.99] synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99] synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99] synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99] synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99] xref: EC:3.2.1.99 xref: MetaCyc:3.2.1.99-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046559 name: alpha-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139] synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139] synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139] xref: EC:3.2.1.139 xref: MetaCyc:3.2.1.139-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046560 name: obsolete scytalidopepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32] comment: This term was made obsolete because it represents a gene product. synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32] synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32] synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] synonym: "scytalidopepsin B activity" EXACT [] synonym: "SLB" RELATED [EC:3.4.23.32] xref: EC:3.4.23.32 xref: MetaCyc:3.4.23.32-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0046561 name: obsolete penicillopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20] comment: This term was made obsolete because it represents a gene product. synonym: "acid protease A" EXACT [] synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20] synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20] synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "penicillopepsin activity" EXACT [] synonym: "peptidase A activity" BROAD [EC:3.4.23.20] xref: EC:3.4.23.20 xref: MetaCyc:3.4.23.20-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0046562 name: glucose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah] synonym: "beta-D-glucose oxidase activity" EXACT [] synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4] synonym: "corylophyline" RELATED [EC:1.1.3.4] synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4] synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4] synonym: "deoxin-1" RELATED [EC:1.1.3.4] synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4] synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4] synonym: "GOD activity" RELATED [EC:1.1.3.4] synonym: "microcid" RELATED [EC:1.1.3.4] synonym: "penatin" RELATED [EC:1.1.3.4] xref: EC:1.1.3.4 xref: KEGG_REACTION:R01522 xref: MetaCyc:GLUCOSE-OXIDASE-RXN xref: RHEA:11428 is_a: GO:0047979 ! hexose oxidase activity [Term] id: GO:0046563 name: methanol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN] comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). xref: EC:1.1.3 xref: MetaCyc:METHANOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0046564 name: oxalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxalate = CO(2) + formate." [EC:4.1.1.2, RHEA:16509] synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2] synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2] xref: EC:4.1.1.2 xref: KEGG_REACTION:R00522 xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN xref: RHEA:16509 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0046565 name: 3-dehydroshikimate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.118, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN] xref: EC:4.2.1.118 xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN xref: RHEA:24848 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0046566 name: DOPA dioxygenase activity namespace: molecular_function def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071] synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT [] xref: MetaCyc:RXN-8460 is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0046567 name: aphidicolan-16 beta-ol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate." [EC:4.2.3.42, PMID:12149019] synonym: "9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)" EXACT [EC:4.2.3.42] xref: EC:4.2.3.42 xref: KEGG_REACTION:R06313 xref: MetaCyc:RXN-10631 xref: RHEA:26213 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0046568 name: 3-methylbutanol:NAD(P) oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265] synonym: "3-methylbutanal reductase [NAD(P)] activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase activity" EXACT [] synonym: "isoamyl alcohol oxidase activity" EXACT [] xref: EC:1.1.1.265 xref: MetaCyc:1.1.1.265-RXN is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity [Term] id: GO:0046569 name: glyoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [PMID:11733005] synonym: "GLOX" EXACT [] is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0046570 name: methylthioribulose 1-phosphate dehydratase activity namespace: molecular_function alt_id: GO:0043809 def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O." [EC:4.2.1.109, RHEA:15549] synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109] synonym: "5-methylthioribulose-1-phosphate 4-dehydratase activity" EXACT [MetaCyc:R145-RXN] synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT [] synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT [] xref: EC:4.2.1.109 xref: KEGG_REACTION:R07392 xref: MetaCyc:R145-RXN xref: Reactome:R-HSA-1237140 "Dehydration of methylthio-ribulose-P" xref: RHEA:15549 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0046571 name: aspartate-2-keto-4-methylthiobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0046572 name: versicolorin B synthase activity namespace: molecular_function def: "Catalysis of the reaction: versiconal = versicolorin B + H2O." [MetaCyc:RXN-9494, PMID:8784203] xref: EC:4.2.1.143 xref: MetaCyc:RXN-9494 xref: RHEA:33859 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0046573 name: lactonohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0046574 name: glycuronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176] synonym: "glucuronyl hydrolase activity" EXACT [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0046575 name: rhamnogalacturonan acetylesterase activity namespace: molecular_function def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485] is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0046576 name: rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity namespace: molecular_function def: "Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076] synonym: "rhamnogalacturonase B activity" EXACT [PMID:8587995] is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0046577 name: long-chain-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20] synonym: "fatty alcohol oxidase activity" EXACT [] synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20] synonym: "long-chain fatty alcohol oxidase activity" EXACT [] synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] xref: EC:1.1.3.20 xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0046578 name: regulation of Ras protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007265 ! Ras protein signal transduction relationship: regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046579 name: positive regulation of Ras protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] synonym: "activation of Ras protein signal transduction" NARROW [] synonym: "stimulation of Ras protein signal transduction" NARROW [] synonym: "up regulation of Ras protein signal transduction" EXACT [] synonym: "up-regulation of Ras protein signal transduction" EXACT [] synonym: "upregulation of Ras protein signal transduction" EXACT [] is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007265 ! Ras protein signal transduction relationship: positively_regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046580 name: negative regulation of Ras protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] synonym: "down regulation of Ras protein signal transduction" EXACT [] synonym: "down-regulation of Ras protein signal transduction" EXACT [] synonym: "downregulation of Ras protein signal transduction" EXACT [] synonym: "inhibition of Ras protein signal transduction" NARROW [] is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007265 ! Ras protein signal transduction relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction [Term] id: GO:0046581 name: intercellular canaliculus namespace: cellular_component def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0046583 name: cation efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "cation efflux permease activity" EXACT [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0046584 name: enniatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732] synonym: "enniatin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0050761 ! depsipeptide metabolic process is_a: GO:1901334 ! lactone metabolic process [Term] id: GO:0046585 name: enniatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732] synonym: "enniatin anabolism" EXACT [] synonym: "enniatin biosynthesis" EXACT [] synonym: "enniatin formation" EXACT [] synonym: "enniatin synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046584 ! enniatin metabolic process is_a: GO:0050763 ! depsipeptide biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process [Term] id: GO:0046586 name: regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [Term] id: GO:0046587 name: positive regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] synonym: "activation of calcium-dependent cell-cell adhesion" NARROW [] synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW [] synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [Term] id: GO:0046588 name: negative regulation of calcium-dependent cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT [] synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [Term] id: GO:0046589 name: ribonuclease T1 activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3] synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3] synonym: "binase activity" EXACT [EC:3.1.27.3] synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3] synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3] synonym: "ribonuclease C2" RELATED [EC:3.1.27.3] synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3] synonym: "ribonuclease F1" EXACT [] synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3] synonym: "ribonuclease N1" RELATED [EC:3.1.27.3] synonym: "ribonuclease N3" RELATED [EC:3.1.27.3] synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3] synonym: "ribonuclease SA" RELATED [EC:3.1.27.3] synonym: "ribonuclease U1" RELATED [EC:3.1.27.3] synonym: "RNase F1" RELATED [EC:3.1.27.3] synonym: "RNase G" RELATED [EC:3.1.27.3] synonym: "RNase N1 activity" EXACT [EC:3.1.27.3] synonym: "RNase N2 activity" EXACT [EC:3.1.27.3] synonym: "RNase Sa" RELATED [EC:3.1.27.3] synonym: "RNase T1" RELATED [EC:3.1.27.3] synonym: "RNase T1 activity" EXACT [] xref: EC:3.1.27.3 xref: MetaCyc:3.1.27.3-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0046590 name: obsolete embryonic leg morphogenesis namespace: biological_process def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf] comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. synonym: "embryonic leg morphogenesis" EXACT [] is_obsolete: true consider: GO:0030326 consider: GO:0035116 [Term] id: GO:0046591 name: obsolete embryonic leg joint morphogenesis namespace: biological_process def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824] comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. synonym: "embryonic leg joint morphogenesis" EXACT [] is_obsolete: true consider: GO:0036023 [Term] id: GO:0046592 name: polyamine oxidase activity namespace: molecular_function def: "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] xref: EC:1.5.3.11 xref: MetaCyc:POLYAMINE-OXIDASE-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0046593 name: mandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10] synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10] synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10] synonym: "hydroxynitrile lyase activity" BROAD [] synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10] synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10] xref: EC:4.1.2.10 xref: MetaCyc:MANDELONITRILE-LYASE-RXN xref: RHEA:18313 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0046594 name: maintenance of pole plasm mRNA location namespace: biological_process alt_id: GO:0048122 def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb] synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT [] synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051237 ! maintenance of RNA location is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0046595 name: establishment of pole plasm mRNA localization namespace: biological_process alt_id: GO:0048121 def: "Any process that results in the directed movement of mRNA to the oocyte pole plasm." [GOC:bf] synonym: "establishment of oocyte pole plasm mRNA localization" EXACT [] synonym: "establishment of pole plasm mRNA localisation" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0051236 ! establishment of RNA localization relationship: part_of GO:0019094 ! pole plasm mRNA localization [Term] id: GO:0046596 name: regulation of viral entry into host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the viral entry into the host cell." [GOC:jl] synonym: "regulation of viral penetration into host cell" EXACT [] synonym: "viral escort protein" RELATED [GOC:bm] is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046718 ! viral entry into host cell relationship: regulates GO:0046718 ! viral entry into host cell [Term] id: GO:0046597 name: negative regulation of viral entry into host cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell." [GOC:jl] synonym: "negative regulation of viral penetration into host cell" EXACT [] is_a: GO:0046596 ! regulation of viral entry into host cell is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046718 ! viral entry into host cell relationship: negatively_regulates GO:0046718 ! viral entry into host cell [Term] id: GO:0046598 name: positive regulation of viral entry into host cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell." [GOC:jl] synonym: "positive regulation of viral penetration into host cell" EXACT [] is_a: GO:0046596 ! regulation of viral entry into host cell is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046718 ! viral entry into host cell relationship: positively_regulates GO:0046718 ! viral entry into host cell [Term] id: GO:0046599 name: regulation of centriole replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai] is_a: GO:0010824 ! regulation of centrosome duplication is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007099 ! centriole replication relationship: regulates GO:0007099 ! centriole replication [Term] id: GO:0046600 name: negative regulation of centriole replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "down regulation of centriole replication" EXACT [] synonym: "down-regulation of centriole replication" EXACT [] synonym: "downregulation of centriole replication" EXACT [] synonym: "inhibition of centriole replication" NARROW [] is_a: GO:0010826 ! negative regulation of centrosome duplication is_a: GO:0046599 ! regulation of centriole replication is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007099 ! centriole replication relationship: negatively_regulates GO:0007099 ! centriole replication [Term] id: GO:0046601 name: positive regulation of centriole replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai] synonym: "activation of centriole replication" NARROW [] synonym: "stimulation of centriole replication" NARROW [] synonym: "up regulation of centriole replication" EXACT [] synonym: "up-regulation of centriole replication" EXACT [] synonym: "upregulation of centriole replication" EXACT [] is_a: GO:0010825 ! positive regulation of centrosome duplication is_a: GO:0046599 ! regulation of centriole replication is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007099 ! centriole replication relationship: positively_regulates GO:0007099 ! centriole replication [Term] id: GO:0046602 name: regulation of mitotic centrosome separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0046605 ! regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007100 ! mitotic centrosome separation relationship: regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046603 name: negative regulation of mitotic centrosome separation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "down regulation of mitotic centrosome separation" EXACT [] synonym: "down-regulation of mitotic centrosome separation" EXACT [] synonym: "downregulation of mitotic centrosome separation" EXACT [] synonym: "inhibition of mitotic centrosome separation" NARROW [] is_a: GO:0045839 ! negative regulation of mitotic nuclear division is_a: GO:0046602 ! regulation of mitotic centrosome separation is_a: GO:0046606 ! negative regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007100 ! mitotic centrosome separation relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046604 name: positive regulation of mitotic centrosome separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] synonym: "activation of mitotic centrosome separation" NARROW [] synonym: "stimulation of mitotic centrosome separation" NARROW [] synonym: "up regulation of mitotic centrosome separation" EXACT [] synonym: "up-regulation of mitotic centrosome separation" EXACT [] synonym: "upregulation of mitotic centrosome separation" EXACT [] is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:0046602 ! regulation of mitotic centrosome separation is_a: GO:0046607 ! positive regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007100 ! mitotic centrosome separation relationship: positively_regulates GO:0007100 ! mitotic centrosome separation [Term] id: GO:0046605 name: regulation of centrosome cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007098 ! centrosome cycle relationship: regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046606 name: negative regulation of centrosome cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "down regulation of centrosome cycle" EXACT [] synonym: "down-regulation of centrosome cycle" EXACT [] synonym: "downregulation of centrosome cycle" EXACT [] synonym: "inhibition of centrosome cycle" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0046605 ! regulation of centrosome cycle is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007098 ! centrosome cycle relationship: negatively_regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046607 name: positive regulation of centrosome cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai] synonym: "activation of centrosome cycle" NARROW [] synonym: "stimulation of centrosome cycle" NARROW [] synonym: "up regulation of centrosome cycle" EXACT [] synonym: "up-regulation of centrosome cycle" EXACT [] synonym: "upregulation of centrosome cycle" EXACT [] is_a: GO:0046605 ! regulation of centrosome cycle is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007098 ! centrosome cycle relationship: positively_regulates GO:0007098 ! centrosome cycle [Term] id: GO:0046608 name: carotenoid isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677] is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0046609 name: obsolete voltage-gated sulfate antiporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah] comment: This term was obsoleted because there is no evidence that this function exists. synonym: "prestin" NARROW [] synonym: "voltage gated sulfate antiporter activity" EXACT [] synonym: "voltage-dependent sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulfate antiporter activity" EXACT [] synonym: "voltage-sensitive sulphate antiporter activity" EXACT [] is_obsolete: true [Term] id: GO:0046610 name: lysosomal proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: part_of GO:0005764 ! lysosome relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex [Term] id: GO:0046611 name: lysosomal proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT [] synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD [] is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex intersection_of: GO:0033176 ! proton-transporting V-type ATPase complex intersection_of: part_of GO:0005764 ! lysosome relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0046612 name: lysosomal proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: part_of GO:0005764 ! lysosome relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex [Term] id: GO:0046615 name: obsolete re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces. synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000321 [Term] id: GO:0046617 name: obsolete nucleolar size increase (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. synonym: "nucleolar size increase (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0046618 name: drug export namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle." [GOC:go_curators] is_a: GO:0015893 ! drug transport [Term] id: GO:0046619 name: optic placode formation involved in camera-type eye formation namespace: biological_process def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "optic placode formation in camera-type eye" EXACT [] synonym: "optic placode formation involved in camera-style eye" EXACT [] is_a: GO:0001743 ! optic placode formation relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035265 ! organ growth relationship: regulates GO:0035265 ! organ growth [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035265 ! organ growth relationship: negatively_regulates GO:0035265 ! organ growth [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035265 ! organ growth relationship: positively_regulates GO:0035265 ! organ growth [Term] id: GO:0046623 name: sphingolipid floppase activity namespace: molecular_function def: "Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ai, PMID:12034738] synonym: "sphingolipid flippase activity" EXACT [] synonym: "sphingolipid floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "sphingolipid-translocating ATPase activity" RELATED [] is_a: GO:0046624 ! sphingolipid transporter activity is_a: GO:0140328 ! floppase activity relationship: part_of GO:0099039 ! sphingolipid translocation [Term] id: GO:0046624 name: sphingolipid transporter activity namespace: molecular_function def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732] is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0046625 name: sphingolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding [Term] id: GO:0046626 name: regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008286 ! insulin receptor signaling pathway relationship: regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046627 name: negative regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "down regulation of insulin receptor signaling pathway" EXACT [] synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] synonym: "downregulation of insulin receptor signaling pathway" EXACT [] synonym: "inhibition of insulin receptor signaling pathway" NARROW [] synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046628 name: positive regulation of insulin receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] synonym: "activation of insulin receptor signaling pathway" NARROW [] synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] synonym: "stimulation of insulin receptor signaling pathway" NARROW [] synonym: "up regulation of insulin receptor signaling pathway" EXACT [] synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] synonym: "upregulation of insulin receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0046629 name: gamma-delta T cell activation namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "gamma-delta T lymphocyte activation" EXACT [] synonym: "gamma-delta T-cell activation" EXACT [] synonym: "gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation [Term] id: GO:0046630 name: gamma-delta T cell proliferation namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai] synonym: "gamma-delta T lymphocyte proliferation" EXACT [] synonym: "gamma-delta T-cell proliferation" EXACT [] synonym: "gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046631 name: alpha-beta T cell activation namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] synonym: "alpha-beta T lymphocyte activation" EXACT [] synonym: "alpha-beta T-cell activation" EXACT [] synonym: "alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0042110 ! T cell activation [Term] id: GO:0046632 name: alpha-beta T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development" RELATED [GOC:add] synonym: "alpha-beta T lymphocyte differentiation" EXACT [] synonym: "alpha-beta T-cell differentiation" EXACT [] synonym: "alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046633 name: alpha-beta T cell proliferation namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai] synonym: "alpha-beta T lymphocyte proliferation" EXACT [] synonym: "alpha-beta T-cell proliferation" EXACT [] synonym: "alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046634 name: regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "regulation of alpha-beta T-cell activation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046631 ! alpha-beta T cell activation relationship: regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046635 name: positive regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "activation of alpha-beta T cell activation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "positive regulation of alpha-beta T-cell activation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT [] synonym: "stimulation of alpha-beta T cell activation" NARROW [] synonym: "up regulation of alpha-beta T cell activation" EXACT [] synonym: "up-regulation of alpha-beta T cell activation" EXACT [] synonym: "upregulation of alpha-beta T cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046631 ! alpha-beta T cell activation relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046636 name: negative regulation of alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] synonym: "down regulation of alpha-beta T cell activation" EXACT [] synonym: "down-regulation of alpha-beta T cell activation" EXACT [] synonym: "downregulation of alpha-beta T cell activation" EXACT [] synonym: "inhibition of alpha-beta T cell activation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT [] synonym: "negative regulation of alpha-beta T-cell activation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046631 ! alpha-beta T cell activation relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0046637 name: regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046632 ! alpha-beta T cell differentiation relationship: regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046638 name: positive regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of alpha-beta T cell differentiation" NARROW [] synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT [] synonym: "stimulation of alpha-beta T cell differentiation" NARROW [] synonym: "up regulation of alpha-beta T cell differentiation" EXACT [] synonym: "up-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "upregulation of alpha-beta T cell differentiation" EXACT [] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046632 ! alpha-beta T cell differentiation relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046639 name: negative regulation of alpha-beta T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of alpha-beta T cell differentiation" EXACT [] synonym: "down-regulation of alpha-beta T cell differentiation" EXACT [] synonym: "downregulation of alpha-beta T cell differentiation" EXACT [] synonym: "inhibition of alpha-beta T cell differentiation" NARROW [] synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add] synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT [] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0046640 name: regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046633 ! alpha-beta T cell proliferation relationship: regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046641 name: positive regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "activation of alpha-beta T cell proliferation" NARROW [] synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of alpha-beta T cell proliferation" NARROW [] synonym: "up regulation of alpha-beta T cell proliferation" EXACT [] synonym: "up-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "upregulation of alpha-beta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046633 ! alpha-beta T cell proliferation relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046642 name: negative regulation of alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] synonym: "down regulation of alpha-beta T cell proliferation" EXACT [] synonym: "down-regulation of alpha-beta T cell proliferation" EXACT [] synonym: "downregulation of alpha-beta T cell proliferation" EXACT [] synonym: "inhibition of alpha-beta T cell proliferation" NARROW [] synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT [] synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0046643 name: regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "regulation of gamma-delta T-cell activation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046629 ! gamma-delta T cell activation relationship: regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046644 name: negative regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "down regulation of gamma-delta T cell activation" EXACT [] synonym: "down-regulation of gamma-delta T cell activation" EXACT [] synonym: "downregulation of gamma-delta T cell activation" EXACT [] synonym: "inhibition of gamma-delta T cell activation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "negative regulation of gamma-delta T-cell activation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046629 ! gamma-delta T cell activation relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046645 name: positive regulation of gamma-delta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] synonym: "activation of gamma-delta T cell activation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT [] synonym: "positive regulation of gamma-delta T-cell activation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT [] synonym: "stimulation of gamma-delta T cell activation" NARROW [] synonym: "up regulation of gamma-delta T cell activation" EXACT [] synonym: "up-regulation of gamma-delta T cell activation" EXACT [] synonym: "upregulation of gamma-delta T cell activation" EXACT [] is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046629 ! gamma-delta T cell activation relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0046646 name: regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0046643 ! regulation of gamma-delta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046630 ! gamma-delta T cell proliferation relationship: regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046647 name: negative regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "down regulation of gamma-delta T cell proliferation" EXACT [] synonym: "down-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "downregulation of gamma-delta T cell proliferation" EXACT [] synonym: "inhibition of gamma-delta T cell proliferation" NARROW [] synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046648 name: positive regulation of gamma-delta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] synonym: "activation of gamma-delta T cell proliferation" NARROW [] synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT [] synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT [] synonym: "stimulation of gamma-delta T cell proliferation" NARROW [] synonym: "up regulation of gamma-delta T cell proliferation" EXACT [] synonym: "up-regulation of gamma-delta T cell proliferation" EXACT [] synonym: "upregulation of gamma-delta T cell proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046630 ! gamma-delta T cell proliferation relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0046649 name: lymphocyte activation namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0046651 name: lymphocyte proliferation namespace: biological_process def: "The expansion of a lymphocyte population by cell division." [GOC:ai] is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0046653 name: tetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732] synonym: "tetrahydrofolate metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process [Term] id: GO:0046654 name: tetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732] synonym: "tetrahydrofolate anabolism" EXACT [] synonym: "tetrahydrofolate biosynthesis" EXACT [] synonym: "tetrahydrofolate formation" EXACT [] synonym: "tetrahydrofolate synthesis" EXACT [] xref: MetaCyc:FOLSYN-PWY is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0046655 name: folic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732] synonym: "folate metabolic process" EXACT [] synonym: "folate metabolism" EXACT [] synonym: "folic acid metabolism" EXACT [] synonym: "vitamin B9 metabolic process" EXACT [] synonym: "vitamin B9 metabolism" EXACT [] synonym: "vitamin M metabolic process" EXACT [] synonym: "vitamin M metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0046656 name: folic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai] synonym: "folate biosynthesis" EXACT [] synonym: "folate biosynthetic process" EXACT [] synonym: "folic acid anabolism" EXACT [] synonym: "folic acid biosynthesis" EXACT [] synonym: "folic acid formation" EXACT [] synonym: "folic acid synthesis" EXACT [] synonym: "vitamin B9 biosynthesis" EXACT [] synonym: "vitamin B9 biosynthetic process" EXACT [] synonym: "vitamin M biosynthesis" EXACT [] synonym: "vitamin M biosynthetic process" EXACT [] xref: MetaCyc:FOLSYN-PWY xref: Wikipedia:Folic_acid is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046655 ! folic acid metabolic process [Term] id: GO:0046657 name: folic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai] synonym: "folate catabolic process" EXACT [] synonym: "folate catabolism" EXACT [] synonym: "folic acid breakdown" EXACT [] synonym: "folic acid catabolism" EXACT [] synonym: "folic acid degradation" EXACT [] synonym: "vitamin B9 catabolic process" EXACT [] synonym: "vitamin B9 catabolism" EXACT [] synonym: "vitamin M catabolic process" EXACT [] synonym: "vitamin M catabolism" EXACT [] is_a: GO:0009397 ! folic acid-containing compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046655 ! folic acid metabolic process [Term] id: GO:0046658 name: anchored component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] synonym: "anchored to plasma membrane" NARROW [] synonym: "plasma membrane, GPI-anchored" NARROW [] is_a: GO:0031225 ! anchored component of membrane is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0005886 ! plasma membrane [Term] id: GO:0046659 name: digestive hormone activity namespace: molecular_function def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai] synonym: "secretin" NARROW [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0046660 name: female sex differentiation namespace: biological_process def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0046661 name: male sex differentiation namespace: biological_process def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0046662 name: regulation of oviposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018991 ! oviposition relationship: regulates GO:0018991 ! oviposition [Term] id: GO:0046663 name: dorsal closure, leading edge cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138] is_a: GO:0035026 ! leading edge cell differentiation intersection_of: GO:0035026 ! leading edge cell differentiation intersection_of: part_of GO:0007391 ! dorsal closure relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0046664 name: dorsal closure, amnioserosa morphology change namespace: biological_process def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0046665 name: amnioserosa maintenance namespace: biological_process def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0046666 name: retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the developing retina." [GOC:bf] synonym: "programmed cell death, retina cells" EXACT [] synonym: "programmed cell death, retinal cells" EXACT [] synonym: "retina cell programmed cell death" EXACT [] synonym: "retina programmed cell death" EXACT [] synonym: "retinal programmed cell death" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0046667 name: compound eye retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] is_a: GO:0046666 ! retinal cell programmed cell death relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0046668 name: regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0060284 ! regulation of cell development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046666 ! retinal cell programmed cell death relationship: regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046669 name: regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046668 ! regulation of retinal cell programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046667 ! compound eye retinal cell programmed cell death relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046670 name: positive regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "activation of retinal programmed cell death" NARROW [] synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] synonym: "stimulation of retinal programmed cell death" NARROW [] synonym: "up regulation of retinal programmed cell death" EXACT [] synonym: "up-regulation of retinal programmed cell death" EXACT [] synonym: "upregulation of retinal programmed cell death" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046666 ! retinal cell programmed cell death relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046671 name: negative regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "down regulation of retinal programmed cell death" EXACT [] synonym: "down-regulation of retinal programmed cell death" EXACT [] synonym: "downregulation of retinal programmed cell death" EXACT [] synonym: "inhibition of retinal programmed cell death" NARROW [] synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046666 ! retinal cell programmed cell death relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death [Term] id: GO:0046672 name: positive regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "activation of retinal cell programmed cell death" BROAD [] synonym: "positive regulation of retinal cell programmed cell death" BROAD [] synonym: "stimulation of retinal cell programmed cell death" BROAD [] synonym: "up regulation of retinal cell programmed cell death" BROAD [] synonym: "up-regulation of retinal cell programmed cell death" BROAD [] synonym: "upregulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046673 name: negative regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "down regulation of retinal cell programmed cell death" BROAD [] synonym: "down-regulation of retinal cell programmed cell death" BROAD [] synonym: "downregulation of retinal cell programmed cell death" BROAD [] synonym: "inhibition of retinal cell programmed cell death" BROAD [] synonym: "negative regulation of retina cell programmed cell death" BROAD [] synonym: "negative regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death [Term] id: GO:0046676 name: negative regulation of insulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] synonym: "down regulation of insulin secretion" EXACT [] synonym: "down-regulation of insulin secretion" EXACT [] synonym: "downregulation of insulin secretion" EXACT [] synonym: "inhibition of insulin secretion" NARROW [] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030073 ! insulin secretion relationship: negatively_regulates GO:0030073 ! insulin secretion [Term] id: GO:0046677 name: response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] subset: goslim_chembl synonym: "antibiotic susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0046678 name: response to bacteriocin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544] synonym: "bacteriocin susceptibility/resistance" RELATED [] is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide [Term] id: GO:0046679 name: response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators] synonym: "streptomycin susceptibility/resistance" RELATED [] is_a: GO:0042493 ! response to drug is_a: GO:0060992 ! response to fungicide is_a: GO:1903416 ! response to glycoside [Term] id: GO:0046680 name: response to DDT namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] synonym: "DDT resistance" RELATED [] synonym: "DDT susceptibility/resistance" RELATED [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0017085 ! response to insecticide is_a: GO:0042493 ! response to drug [Term] id: GO:0046681 name: response to carbamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544] synonym: "carbamate resistance" RELATED [] synonym: "carbamate susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide is_a: GO:0043200 ! response to amino acid [Term] id: GO:0046682 name: response to cyclodiene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099] synonym: "cyclodiene resistance" RELATED [] synonym: "cyclodiene susceptibility/resistance" RELATED [] is_a: GO:0010033 ! response to organic substance is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046683 name: response to organophosphorus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] synonym: "organophosphorus resistance" RELATED [] synonym: "organophosphorus susceptibility/resistance" RELATED [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0046684 name: response to pyrethroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544] synonym: "pyrethroid resistance" RELATED [] synonym: "pyrethroid susceptibility/resistance" RELATED [] is_a: GO:0017085 ! response to insecticide [Term] id: GO:0046685 name: response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544] synonym: "arsenate sensitivity/resistance" RELATED [] synonym: "response to arsenic" EXACT [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0046686 name: response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] synonym: "cadmium sensitivity/resistance" RELATED [] synonym: "response to cadmium" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046687 name: response to chromate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544] synonym: "chromate sensitivity/resistance" RELATED [] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0046688 name: response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] synonym: "copper sensitivity/resistance" RELATED [] synonym: "response to copper" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046689 name: response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] synonym: "mercuric sensitivity/resistance" RELATED [] synonym: "response to mercuric ion" NARROW [GOC:mah] synonym: "response to mercury" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0046690 name: response to tellurium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai] synonym: "response to tellurium" EXACT [] synonym: "tellurium sensitivity/resistance" RELATED [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0046691 name: intracellular canaliculus namespace: cellular_component def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544, PMID:10700045] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016324 ! apical plasma membrane [Term] id: GO:0046692 name: sperm competition namespace: biological_process def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] xref: Wikipedia:Sperm_competition is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination [Term] id: GO:0046693 name: sperm storage namespace: biological_process def: "The retention of sperm by a female following mating." [PMID:10885514] synonym: "retention of sperm" EXACT [] synonym: "sequestering of sperm" EXACT [] synonym: "sequestration of sperm" EXACT [] synonym: "sperm retention" EXACT [] synonym: "sperm sequestering" EXACT [] synonym: "sperm sequestration" EXACT [] synonym: "storage of sperm" EXACT [] is_a: GO:0046692 ! sperm competition [Term] id: GO:0046694 name: sperm incapacitation namespace: biological_process def: "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0046695 name: SLIK (SAGA-like) complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:12101232, PMID:12186975, PMID:17337012] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SAGA (alt) complex" EXACT [] synonym: "SALSA complex" EXACT [] synonym: "SLIK/SALSA complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex relationship: has_part GO:0071819 ! DUBm complex [Term] id: GO:0046696 name: lipopolysaccharide receptor complex namespace: cellular_component def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens." [PMID:11706042, PMID:9665271] comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. synonym: "LPS receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0046697 name: decidualization namespace: biological_process def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544, PMID:11133685] synonym: "decidual cell reaction" EXACT [] xref: Wikipedia:Decidualization is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0001893 ! maternal placenta development [Term] id: GO:0046700 name: heterocycle catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] synonym: "heterocycle breakdown" EXACT [] synonym: "heterocycle catabolism" EXACT [] synonym: "heterocycle degradation" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0046701 name: insecticide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] synonym: "insecticide breakdown" EXACT [] synonym: "insecticide catabolism" EXACT [] synonym: "insecticide degradation" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0046702 name: galactoside 6-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479] is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity [Term] id: GO:0046703 name: natural killer cell lectin-like receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lectin-like natural killer cell receptor." [GOC:ai] synonym: "KLRC4 receptor binding" NARROW [] synonym: "NK cell lectin-like receptor binding" EXACT [] synonym: "NKG2D receptor binding" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0046704 name: CDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai] synonym: "CDP metabolism" EXACT [] is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0046705 name: CDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai] synonym: "CDP anabolism" EXACT [] synonym: "CDP biosynthesis" EXACT [] synonym: "CDP formation" EXACT [] synonym: "CDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046704 ! CDP metabolic process [Term] id: GO:0046706 name: CDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai] synonym: "CDP breakdown" EXACT [] synonym: "CDP catabolism" EXACT [] synonym: "CDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046704 ! CDP metabolic process [Term] id: GO:0046707 name: IDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai] synonym: "IDP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process [Term] id: GO:0046708 name: IDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai] synonym: "IDP anabolism" EXACT [] synonym: "IDP biosynthesis" EXACT [] synonym: "IDP formation" EXACT [] synonym: "IDP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0046709 name: IDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai] synonym: "IDP breakdown" EXACT [] synonym: "IDP catabolism" EXACT [] synonym: "IDP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0046710 name: GDP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai] synonym: "GDP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0046711 name: GDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai] synonym: "GDP anabolism" EXACT [] synonym: "GDP biosynthesis" EXACT [] synonym: "GDP formation" EXACT [] synonym: "GDP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046710 ! GDP metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0046712 name: GDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai] synonym: "GDP breakdown" EXACT [] synonym: "GDP catabolism" EXACT [] synonym: "GDP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process is_a: GO:0046710 ! GDP metabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0046713 name: borate transport namespace: biological_process def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [PMID:21710975] synonym: "boron transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0015893 ! drug transport [Term] id: GO:0046714 name: borate binding namespace: molecular_function def: "Interacting selectively and non-covalently with borate, the anion (BO3)3-." [GOC:curators] synonym: "boron binding" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding [Term] id: GO:0046715 name: active borate transmembrane transporter activity namespace: molecular_function alt_id: GO:0080138 def: "Enables the transport of borate across a membrane against the concentration gradient." [PMID:12447444] synonym: "borate transmembrane transporter activity" BROAD [] synonym: "borate uptake transmembrane transporter activity" RELATED [] synonym: "boron transmembrane transporter activity" RELATED [] synonym: "boron uptake transmembrane transporter activity" RELATED [] synonym: "efflux-type borate transporter" NARROW [] synonym: "efflux-type boron transporter" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity relationship: part_of GO:0035445 ! borate transmembrane transport created_by: donghui creation_date: 2009-05-19T04:09:56Z [Term] id: GO:0046716 name: muscle cell cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] synonym: "muscle homeostasis" RELATED [GOC:dph] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0046717 name: acid secretion namespace: biological_process def: "The controlled release of acid by a cell or a tissue." [GOC:ai] is_a: GO:0046903 ! secretion [Term] id: GO:0046718 name: viral entry into host cell namespace: biological_process alt_id: GO:0019063 def: "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl] comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location. subset: goslim_metagenomics synonym: "entry of virus into host cell" EXACT [] synonym: "phage translocation" EXACT [] synonym: "viral penetration" EXACT [] synonym: "virion penetration" EXACT [] synonym: "virion penetration into host cell" EXACT [] synonym: "virus entry into host cell" EXACT [GOC:bf] xref: VZ:936 is_a: GO:0030260 ! entry into host cell relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0046719 name: regulation by virus of viral protein levels in host cell namespace: biological_process def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai] synonym: "regulation of viral protein levels" EXACT [] is_a: GO:0048878 ! chemical homeostasis is_a: GO:0050792 ! regulation of viral process [Term] id: GO:0046720 name: citric acid secretion namespace: biological_process def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue." [GOC:ai] synonym: "citrate secretion" EXACT [] is_a: GO:0015746 ! citrate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046721 name: formic acid secretion namespace: biological_process def: "The controlled release of formic acid, HCOOH, by a cell or a tissue." [GOC:ai] synonym: "formate secretion" EXACT [] is_a: GO:0015724 ! formate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046722 name: lactic acid secretion namespace: biological_process def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai] synonym: "lactate secretion" EXACT [] is_a: GO:0035879 ! plasma membrane lactate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046723 name: malic acid secretion namespace: biological_process def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue." [GOC:ai] synonym: "hydroxysuccinic acid secretion" EXACT [] synonym: "malate secretion" EXACT [] is_a: GO:0015743 ! malate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046724 name: oxalic acid secretion namespace: biological_process def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue." [GOC:ai] synonym: "oxalate secretion" EXACT [] is_a: GO:0019532 ! oxalate transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0046725 name: negative regulation by virus of viral protein levels in host cell namespace: biological_process def: "Any process where the infecting virus reduces the levels of viral proteins in a cell." [GOC:ai] synonym: "down regulation of viral protein levels in host cell" EXACT [] synonym: "down-regulation of viral protein levels in host cell" EXACT [] synonym: "downregulation of viral protein levels in host cell" EXACT [] synonym: "inhibition of viral protein levels in host cell" NARROW [] synonym: "negative regulation of viral protein levels" EXACT [] is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell is_a: GO:0048525 ! negative regulation of viral process [Term] id: GO:0046726 name: positive regulation by virus of viral protein levels in host cell namespace: biological_process def: "Any process where the infecting virus increases the levels of viral proteins in a cell." [GOC:ai] synonym: "activation of viral protein levels in host cell" NARROW [] synonym: "positive regulation of viral protein levels" EXACT [] synonym: "stimulation of viral protein levels in host cell" NARROW [] synonym: "up regulation of viral protein levels in host cell" EXACT [] synonym: "up-regulation of viral protein levels in host cell" EXACT [] synonym: "upregulation of viral protein levels in host cell" EXACT [] is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell is_a: GO:0048524 ! positive regulation of viral process [Term] id: GO:0046727 name: capsomere namespace: cellular_component def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732] synonym: "capsomer" EXACT [] xref: Wikipedia:Capsomere is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046729 name: viral procapsid namespace: cellular_component def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272] is_a: GO:0044423 ! virion part [Term] id: GO:0046730 name: induction of host immune response by virus namespace: biological_process alt_id: GO:0046731 alt_id: GO:0046732 alt_id: GO:0046733 alt_id: GO:0046734 alt_id: GO:0046735 def: "The induction by a virus of an immune response in the host organism." [GOC:jl] synonym: "activation of host immune response by virus" EXACT [] synonym: "active induction of host immune response by virus" RELATED [] synonym: "active viral induction of host immune response" RELATED [] synonym: "passive activation of host immune response by virus" NARROW [] synonym: "passive induction of cell-mediated immune response in host by virus" NARROW [] synonym: "passive induction of host cell-mediated immune response by virus" NARROW [] synonym: "passive induction of host humoral immune response by virus" NARROW [] synonym: "passive induction of host immune response by virus" NARROW [] synonym: "passive induction of host innate immune response by virus" NARROW [] synonym: "passive induction of humoral immune response in host by virus" NARROW [] synonym: "passive induction of innate immune response in host by virus" NARROW [] synonym: "passive viral activation of cell-mediated immune response in host" NARROW [] synonym: "passive viral activation of humoral immune response in host" NARROW [] synonym: "passive viral activation of innate immune response in host" NARROW [] synonym: "passive viral induction of cell-mediated immune response in host" NARROW [] synonym: "passive viral induction of host immune response" NARROW [] synonym: "passive viral induction of humoral immune response in host" NARROW [] synonym: "passive viral induction of innate immune response in host" NARROW [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0075528 ! modulation by virus of host immune response [Term] id: GO:0046736 name: induction of humoral immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [GOC:jl] synonym: "active induction of humoral immune response in host by virus" RELATED [] synonym: "active viral induction of humoral immune response in host" EXACT [] is_a: GO:0046730 ! induction of host immune response by virus [Term] id: GO:0046737 name: induction of cell-mediated immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [GOC:jl] synonym: "active induction of cell-mediated immune response in host by virus" RELATED [] synonym: "active viral induction of cell-mediated immune response in host" EXACT [] is_a: GO:0046730 ! induction of host immune response by virus [Term] id: GO:0046738 name: induction of innate immune response in host by virus namespace: biological_process def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [GOC:jl] synonym: "active induction of innate immune response in host by virus" RELATED [] synonym: "active viral induction of innate immune response in host" EXACT [] is_a: GO:0046730 ! induction of host immune response by virus [Term] id: GO:0046739 name: transport of virus in multicellular host namespace: biological_process def: "The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs)." [GOC:bf, GOC:jl, ISBN:0781718325] synonym: "spread of virus in multicellular host" RELATED [GOC:bf, GOC:jl] synonym: "spread of virus within multicellular host" EXACT [] synonym: "viral spread within multicellular host" EXACT [] is_a: GO:0044000 ! movement in host is_a: GO:0046794 ! transport of virus [Term] id: GO:0046740 name: transport of virus in host, cell to cell namespace: biological_process def: "The transport of a virus between adjacent cells in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325] synonym: "cell to cell spread of virus within host" EXACT [] synonym: "intercellular virus transport" EXACT [GOC:bf, GOC:jl] synonym: "spread of virus in host, cell to cell" RELATED [GOC:bf, GOC:jl] synonym: "spread of virus within host, cell to cell" EXACT [] synonym: "viral spread within host, cell to cell" EXACT [] xref: VZ:1018 is_a: GO:0046739 ! transport of virus in multicellular host is_a: GO:1902586 ! multi-organism intercellular transport [Term] id: GO:0046741 name: transport of virus in host, tissue to tissue namespace: biological_process def: "The transport of a virus between tissues in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325] synonym: "spread of virus in host, tissue to tissue" RELATED [GOC:bf, GOC:jl] synonym: "spread of virus within host, tissue to tissue" EXACT [] synonym: "tissue to tissue spread of virus within host" EXACT [] synonym: "viral spread within host, tissue to tissue" EXACT [] is_a: GO:0046739 ! transport of virus in multicellular host [Term] id: GO:0046745 name: viral capsid secondary envelopment namespace: biological_process alt_id: GO:0046746 alt_id: GO:0046747 alt_id: GO:0046748 alt_id: GO:0046768 alt_id: GO:0046769 alt_id: GO:0046770 def: "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0072370319, ISBN:0781718325, PMID:11533156] synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "ER membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "Golgi membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] synonym: "plasma membrane viral budding during viral capsid re-envelopment" RELATED [] synonym: "viral budding from ER membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from ER membrane during viral capsid re-envelopment" RELATED [] synonym: "viral budding from Golgi membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" RELATED [] synonym: "viral budding from inner nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [] synonym: "viral budding from nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" RELATED [] synonym: "viral budding from outer nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT [] synonym: "viral budding from plasma membrane by viral capsid re-envelopment" EXACT [] synonym: "viral budding from plasma membrane during viral capsid re-envelopment" RELATED [] synonym: "viral capsid re-envelopment" RELATED [GOC:bf, GOC:jl] synonym: "virus budding from ER membrane by viral capsid re-envelopment" EXACT [] synonym: "virus budding from ER membrane during viral capsid re-envelopment" RELATED [GOC:tb] synonym: "virus budding from Golgi membrane by viral capsid re-envelopment" EXACT [] synonym: "virus budding from Golgi membrane during viral capsid re-envelopment" RELATED [GOC:tb] synonym: "virus budding from inner nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "virus budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] synonym: "virus budding from nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "virus budding from nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] synonym: "virus budding from outer nuclear membrane by viral capsid re-envelopment" EXACT [] synonym: "virus budding from outer nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] synonym: "virus budding from plasma membrane during viral capsid re-envelopment" RELATED [GOC:tb] is_a: GO:0016032 ! viral process [Term] id: GO:0046752 name: viral capsid precursor transport to host cell nucleus namespace: biological_process def: "Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325] synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" BROAD [] synonym: "localization of viral capsid precursors in nucleus" BROAD [] synonym: "nuclear localization of viral capsid precursors" BROAD [] synonym: "viral capsid precursor localisation in host cell nucleus" BROAD [GOC:mah] synonym: "viral capsid precursor localization in host cell nucleus" BROAD [] synonym: "viral capsid precursor localization to host cell nucleus" BROAD [GOC:bf, GOC:jl] is_a: GO:0030581 ! symbiont intracellular protein transport in host is_a: GO:0042000 ! translocation of peptides or proteins into host relationship: part_of GO:0039708 ! nuclear capsid assembly [Term] id: GO:0046753 name: non-lytic viral release namespace: biological_process def: "The exit of a viral particle from a cell that does not involve cell lysis." [GOC:bf, GOC:jl, ISBN:0072370319] is_a: GO:0019076 ! viral release from host cell is_a: GO:0046794 ! transport of virus [Term] id: GO:0046754 name: viral exocytosis namespace: biological_process def: "The exit of enveloped or unenveloped virion particles from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319] is_a: GO:0046753 ! non-lytic viral release [Term] id: GO:0046755 name: viral budding namespace: biological_process alt_id: GO:0046744 def: "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947] synonym: "viral capsid envelopment" RELATED [] synonym: "virion budding" NARROW [] synonym: "virus budding" RELATED [] xref: VZ:1947 "Viral budding" is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0046757 name: obsolete lytic virus budding from ER membrane namespace: biological_process def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] comment: This term was made obsolete because it does not appear to correspond to a real biological process. synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT [] synonym: "lytic ER membrane viral budding" EXACT [] synonym: "lytic viral budding from ER membrane" EXACT [] synonym: "lytic virus budding from ER membrane" EXACT [] is_obsolete: true [Term] id: GO:0046758 name: obsolete lytic virus budding from Golgi membrane namespace: biological_process def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] comment: This term was made obsolete because it does not appear to correspond to a real biological process. synonym: "lytic Golgi membrane viral budding" EXACT [] synonym: "lytic viral budding from Golgi membrane" EXACT [] synonym: "lytic virus budding from Golgi membrane" EXACT [] is_obsolete: true [Term] id: GO:0046759 name: obsolete lytic virus budding from plasma membrane namespace: biological_process def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] comment: This term was made obsolete because it does not appear to correspond to a real biological process. synonym: "lytic plasma membrane viral budding" EXACT [] synonym: "lytic viral budding from plasma membrane" EXACT [] synonym: "lytic virus budding from plasma membrane" EXACT [] is_obsolete: true [Term] id: GO:0046760 name: viral budding from Golgi membrane namespace: biological_process alt_id: GO:0046750 alt_id: GO:0046763 def: "A viral budding that starts with formation of a membrane curvature in the host Golgi membrane." [GOC:bf, ISBN:0072370319, VZ:1947] synonym: "Golgi membrane viral budding" EXACT [] synonym: "Golgi membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from Golgi membrane by viral capsid envelopment" RELATED [] synonym: "viral budding from Golgi membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from Golgi membrane" EXACT [] synonym: "virus budding from Golgi membrane by viral capsid envelopment" RELATED [] synonym: "virus budding from Golgi membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046755 ! viral budding [Term] id: GO:0046761 name: viral budding from plasma membrane namespace: biological_process alt_id: GO:0046766 alt_id: GO:0046767 def: "A viral budding that starts with formation of a membrane curvature in the host plasma membrane." [GOC:bf, ISBN:0072370319, PMID:9394621, VZ:1947] synonym: "plasma membrane viral budding" EXACT [] synonym: "plasma membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from plasma membrane by viral capsid envelopment" RELATED [] synonym: "viral budding from plasma membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from plasma membrane" EXACT [] synonym: "virus budding from plasma membrane by viral capsid envelopment" EXACT [] synonym: "virus budding from plasma membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046753 ! non-lytic viral release is_a: GO:0046755 ! viral budding [Term] id: GO:0046762 name: viral budding from ER membrane namespace: biological_process alt_id: GO:0046751 alt_id: GO:0046764 def: "A viral budding that starts with formation of a membrane curvature in the host ER membrane." [GOC:bf, GOC:jl, ISBN:0072370319, VZ:1947] synonym: "endoplasmic reticulum membrane viral budding" EXACT [] synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" RELATED [] synonym: "ER membrane viral budding" EXACT [] synonym: "ER membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from ER membrane by viral capsid envelopment" RELATED [] synonym: "viral budding from ER membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from ER membrane" EXACT [] synonym: "virus budding from ER membrane by viral capsid envelopment" EXACT [] synonym: "virus budding from ER membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046755 ! viral budding [Term] id: GO:0046765 name: viral budding from nuclear membrane namespace: biological_process alt_id: GO:0046749 def: "A viral budding that starts with formation of a membrane curvature in the host nuclear membrane." [GOC:bf, ISBN:0072370319] synonym: "nuclear membrane viral budding" EXACT [] synonym: "nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from nuclear membrane by viral capsid envelopment" RELATED [] synonym: "viral budding from nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from nuclear membrane" EXACT [] synonym: "virus budding from nuclear membrane by viral capsid envelopment" EXACT [] synonym: "virus budding from nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046755 ! viral budding relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress [Term] id: GO:0046771 name: viral budding from inner nuclear membrane namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "inner nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from inner nuclear membrane by viral capsid envelopment" RELATED [] synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from inner nuclear membrane by viral capsid envelopment" EXACT [] synonym: "virus budding from inner nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046765 ! viral budding from nuclear membrane [Term] id: GO:0046772 name: viral budding from outer nuclear membrane namespace: biological_process def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] synonym: "outer nuclear membrane viral budding during viral capsid envelopment" RELATED [] synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" RELATED [] synonym: "virus budding from outer nuclear membrane by viral capsid envelopment" EXACT [] synonym: "virus budding from outer nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] is_a: GO:0046765 ! viral budding from nuclear membrane [Term] id: GO:0046773 name: suppression by virus of host translation termination namespace: biological_process def: "Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA." [ISBN:0781718325] synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT [] synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT [] synonym: "suppression by virus of host termination of protein biosynthetic process" RELATED [] synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT [] synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT [] synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT [] synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT [] synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT [] synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT [] is_a: GO:0019057 ! modulation by virus of host translation [Term] id: GO:0046774 name: suppression by virus of host intracellular interferon activity namespace: biological_process def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382] synonym: "negative regulation by virus of intracellular interferon activity" EXACT [] synonym: "suppression by virus of intracellular interferon activity in host" EXACT [] is_a: GO:0030683 ! mitigation of host immune response by virus is_a: GO:0075528 ! modulation by virus of host immune response [Term] id: GO:0046775 name: suppression by virus of host cytokine production namespace: biological_process def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382] synonym: "negative regulation by virus of host cytokine production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0044831 ! modulation by virus of host cytokine production is_a: GO:0052562 ! suppression by symbiont of host immune response intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0046776 name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, GOC:bf, PMID:10859382, UniProtKB-KW:KW-1115, VZ:819] synonym: "inhibition of host MHC class I molecule presentation by virus" EXACT [UniProtKB-KW:KW-1115] synonym: "major histocompatibility complex" RELATED [] synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT [] synonym: "suppression by virus of host MHC class I cell surface presentation" EXACT [GOC:add] synonym: "suppression by virus of MHC class I cell surface presentation in host" EXACT [] xref: VZ:819 "Inhibition of host MHC class I molecule presentation by virus" is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0046777 name: protein autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf] xref: MIPS_funcat:14.07.03 xref: Wikipedia:Autophosphorylation is_a: GO:0006468 ! protein phosphorylation [Term] id: GO:0046778 name: modification by virus of host mRNA processing namespace: biological_process def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325] synonym: "viral perturbation of host mRNA processing" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0050684 ! regulation of mRNA processing [Term] id: GO:0046779 name: obsolete suppression by virus of expression of host genes with introns namespace: biological_process def: "OBSOLETE. Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019] comment: The reason for obsoleting this term is that it is too specific. synonym: "negative regulation by virus of expression of host genes with introns" EXACT [] synonym: "viral inhibition of expression of host genes with introns" EXACT [] is_obsolete: true [Term] id: GO:0046780 name: suppression by virus of host mRNA splicing namespace: biological_process alt_id: GO:0046781 def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325, PMID:19729513] synonym: "negative regulation by virus of host mRNA splicing" EXACT [] synonym: "suppression by virus of host splicing factor activity" EXACT [] synonym: "viral dispersion of host splicing factors" EXACT [] synonym: "viral inhibition of host mRNA splicing" EXACT [] is_a: GO:0033119 ! negative regulation of RNA splicing is_a: GO:0039524 ! suppression by virus of host mRNA processing [Term] id: GO:0046782 name: regulation of viral transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai] is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019083 ! viral transcription relationship: regulates GO:0019083 ! viral transcription [Term] id: GO:0046783 name: modification by virus of host polysomes namespace: biological_process def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802] comment: See also the cellular component term 'polysome ; GO:0005844'. synonym: "viral perturbation of polysomes" EXACT [] is_a: GO:0019057 ! modulation by virus of host translation [Term] id: GO:0046784 name: viral mRNA export from host cell nucleus namespace: biological_process def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019] synonym: "intronless viral mRNA export from host cell nucleus" EXACT [] synonym: "intronless viral mRNA export from host nucleus" RELATED [] synonym: "intronless viral mRNA export out of nucleus" EXACT [] synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "intronless viral mRNA-nucleus export" EXACT [] is_a: GO:0044417 ! translocation of molecules into host [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] synonym: "microtubule assembly" EXACT [] synonym: "microtubule formation" RELATED [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0046786 name: viral replication complex formation and maintenance namespace: biological_process def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325] is_a: GO:0016032 ! viral process relationship: part_of GO:0019079 ! viral genome replication [Term] id: GO:0046787 name: viral DNA repair namespace: biological_process def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325] is_a: GO:0006281 ! DNA repair relationship: part_of GO:0016032 ! viral process [Term] id: GO:0046789 name: host cell surface receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor on the host cell surface." [GOC:ai, PMID:11511370] subset: goslim_chembl synonym: "cell surface antigen activity, host-interacting" RELATED [] synonym: "cell surface receptor ligand" RELATED [] is_a: GO:0046812 ! host cell surface binding relationship: part_of GO:0044650 ! adhesion of symbiont to host cell [Term] id: GO:0046790 name: virion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0046791 name: obsolete suppression by virus of host complement neutralization namespace: biological_process def: "OBSOLETE. Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354] comment: This term was made obsolete because the meaning of the term is unclear. It most likely refers to inhibiting the process by which a virus particle is neutralized by the host cell in a complement-dependent manner. synonym: "negative regulation by virus of host complement neutralization" EXACT [] synonym: "suppression by virus of host complement neutralization" EXACT [] is_obsolete: true [Term] id: GO:0046792 name: suppression by virus of host cell cycle arrest namespace: biological_process def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605] synonym: "negative regulation by virus of cell cycle arrest" EXACT [] synonym: "viral inhibition of cell cycle arrest" EXACT [] is_a: GO:0019055 ! modification by virus of host cell cycle regulation [Term] id: GO:0046793 name: induction by virus of phosphorylation of host RNA polymerase II namespace: biological_process def: "Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II." [PMID:7637000] synonym: "induction by virus of modification of host RNA polymerase II" BROAD [GOC:bf, GOC:jl] synonym: "virus-induced modification of host RNA polymerase II" EXACT [] is_a: GO:0019056 ! modulation by virus of host transcription is_a: GO:0039614 ! induction by virus of host protein phosphorylation [Term] id: GO:0046794 name: transport of virus namespace: biological_process def: "The directed movement of a virus, or part of a virus, into, out of, or within a host cell." [GOC:ai] subset: goslim_pir synonym: "viral transport" EXACT [GOC:bf, GOC:jl] synonym: "virion transport" NARROW [GOC:bf, GOC:jl] is_a: GO:0016032 ! viral process is_a: GO:0044766 ! multi-organism transport [Term] id: GO:0046797 name: viral procapsid maturation namespace: biological_process def: "The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure." [GOC:bf, PMID:10627558, PMID:19204733] synonym: "capsid maturation" EXACT [] synonym: "viral capsid maturation" EXACT [PMID:19204733] synonym: "virion maturation" BROAD [UniProtKB-KW:KW-0917] xref: UniProtKB-KW:KW-1273 is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0019069 ! viral capsid assembly relationship: part_of GO:0019075 ! virus maturation [Term] id: GO:0046798 name: viral portal complex namespace: cellular_component def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046799 name: recruitment of helicase-primase complex to DNA lesions namespace: biological_process def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325] is_a: GO:0016032 ! viral process relationship: part_of GO:0046787 ! viral DNA repair [Term] id: GO:0046800 name: obsolete enhancement of virulence namespace: biological_process def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354] comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. synonym: "enhancement of virulence" EXACT [] is_obsolete: true [Term] id: GO:0046802 name: exit of virus from host cell nucleus by nuclear egress namespace: biological_process alt_id: GO:0039676 def: "The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm." [PMID:21494278, PMID:22858153, PMID:9601512, PMID:9765421, VZ:1952] synonym: "capsid egress" EXACT [VZ:2177] synonym: "egress of viral procapsid from host cell nucleus" RELATED [] synonym: "nuclear egress" EXACT [PMID:22858153] synonym: "nuclear egress of viral procapsid" EXACT [] xref: VZ:1952 "Nuclear egress" is_a: GO:0039674 ! exit of virus from host cell nucleus [Term] id: GO:0046803 name: obsolete reduction of virulence namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346] comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. synonym: "reduction of virulence" EXACT [] is_obsolete: true [Term] id: GO:0046804 name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330] synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT [] xref: RESID:AA0330 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046805 name: protein-heme linkage via 1'-L-histidine namespace: biological_process def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329] synonym: "protein-haem linkage via 1'-L-histidine" EXACT [] xref: RESID:AA0329 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0046806 name: viral scaffold namespace: cellular_component def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0046807 name: viral scaffold assembly and maintenance namespace: biological_process def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319] comment: See also the cellular component term 'viral scaffold ; GO:0046806'. is_a: GO:0016032 ! viral process relationship: part_of GO:0019069 ! viral capsid assembly [Term] id: GO:0046808 name: assemblon namespace: cellular_component def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0046809 name: replication compartment namespace: cellular_component def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108, VZ:1951] synonym: "RC" EXACT [VZ:1951] is_a: GO:0039715 ! nuclear viral factory [Term] id: GO:0046810 name: host cell extracellular matrix binding namespace: molecular_function def: "Interacting selectively and non-covalently with the extracellular matrix of a host cell." [PMID:7996163] is_a: GO:0050840 ! extracellular matrix binding [Term] id: GO:0046811 name: histone deacetylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0035033 ! histone deacetylase regulator activity relationship: negatively_regulates GO:0004407 ! histone deacetylase activity relationship: part_of GO:0031064 ! negative regulation of histone deacetylation [Term] id: GO:0046812 name: host cell surface binding namespace: molecular_function def: "Interacting selectively and non-covalently with the surface of a host cell." [GOC:ai] subset: goslim_pir is_a: GO:0005488 ! binding relationship: part_of GO:0044764 ! multi-organism cellular process [Term] id: GO:0046813 name: receptor-mediated virion attachment to host cell namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface." [ISBN:0879694971] synonym: "virion attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] is_a: GO:0019062 ! virion attachment to host cell relationship: has_part GO:0005102 ! signaling receptor binding [Term] id: GO:0046814 name: coreceptor-mediated virion attachment to host cell namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface." [ISBN:0879694971] synonym: "virion attachment, binding of host cell surface coreceptor" EXACT [GOC:bf, GOC:jl] is_a: GO:0019062 ! virion attachment to host cell relationship: has_part GO:0039706 ! co-receptor binding [Term] id: GO:0046815 name: genome retention in viral capsid namespace: biological_process def: "Any process in which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839] is_a: GO:0016032 ! viral process relationship: part_of GO:0019079 ! viral genome replication [Term] id: GO:0046816 name: virion transport vesicle namespace: cellular_component def: "A vesicle used to transport the partial or complete virion between cellular compartments." [GOC:vesicles, PMID:7933124] is_a: GO:0097708 ! intracellular vesicle [Term] id: GO:0046817 name: chemokine receptor antagonist activity namespace: molecular_function def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325] is_a: GO:0048019 ! receptor antagonist activity relationship: part_of GO:0070100 ! negative regulation of chemokine-mediated signaling pathway [Term] id: GO:0046818 name: dense nuclear body namespace: cellular_component def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0046819 name: protein secretion by the type V secretion system namespace: biological_process def: "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators] synonym: "autotransporter system" EXACT [] synonym: "protein secretion by the autotransporter system" EXACT [] synonym: "protein secretion by the type V protein secretion system" EXACT [] synonym: "type V protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0098776 ! protein transport across the cell outer membrane [Term] id: GO:0046820 name: 4-amino-4-deoxychorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [EC:2.6.1.85, RHEA:11672] comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. synonym: "ADC synthase activity" EXACT [EC:2.6.1.85] synonym: "aminodeoxychorismate synthase activity" RELATED [] synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:2.6.1.85] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "PabB activity" RELATED [EC:2.6.1.85] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase activity" RELATED [] xref: EC:2.6.1.85 xref: KEGG_REACTION:R01716 xref: MetaCyc:PABASYN-RXN xref: RHEA:11672 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0046821 name: extrachromosomal DNA namespace: cellular_component def: "DNA structures that are not part of a chromosome." [GOC:ai] xref: Wikipedia:Extrachromosomal_DNA is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0046822 name: regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006913 ! nucleocytoplasmic transport relationship: regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046823 name: negative regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] synonym: "down regulation of nucleocytoplasmic transport" EXACT [] synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] synonym: "downregulation of nucleocytoplasmic transport" EXACT [] synonym: "inhibition of nucleocytoplasmic transport" NARROW [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006913 ! nucleocytoplasmic transport relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046824 name: positive regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] synonym: "activation of nucleocytoplasmic transport" NARROW [] synonym: "stimulation of nucleocytoplasmic transport" NARROW [] synonym: "up regulation of nucleocytoplasmic transport" EXACT [] synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] synonym: "upregulation of nucleocytoplasmic transport" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006913 ! nucleocytoplasmic transport relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0046825 name: regulation of protein export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of protein export from cell nucleus" EXACT [] synonym: "regulation of protein export out of nucleus" EXACT [] synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of protein-nucleus export" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006611 ! protein export from nucleus relationship: regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046826 name: negative regulation of protein export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of protein export from nucleus" EXACT [] synonym: "down-regulation of protein export from nucleus" EXACT [] synonym: "downregulation of protein export from nucleus" EXACT [] synonym: "inhibition of protein export from nucleus" NARROW [] synonym: "negative regulation of protein export from cell nucleus" EXACT [] synonym: "negative regulation of protein export out of nucleus" EXACT [] synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of protein-nucleus export" EXACT [] is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0051457 ! maintenance of protein location in nucleus is_a: GO:0090317 ! negative regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006611 ! protein export from nucleus relationship: negatively_regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046827 name: positive regulation of protein export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of protein export from nucleus" NARROW [] synonym: "positive regulation of protein export from cell nucleus" EXACT [] synonym: "positive regulation of protein export out of nucleus" EXACT [] synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of protein-nucleus export" EXACT [] synonym: "stimulation of protein export from nucleus" NARROW [] synonym: "up regulation of protein export from nucleus" EXACT [] synonym: "up-regulation of protein export from nucleus" EXACT [] synonym: "upregulation of protein export from nucleus" EXACT [] is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0090316 ! positive regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006611 ! protein export from nucleus relationship: positively_regulates GO:0006611 ! protein export from nucleus [Term] id: GO:0046828 name: regulation of RNA import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] synonym: "regulation of RNA import into cell nucleus" EXACT [] synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of RNA-nucleus import" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006404 ! RNA import into nucleus relationship: regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046829 name: negative regulation of RNA import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "down regulation of RNA import into nucleus" EXACT [] synonym: "down-regulation of RNA import into nucleus" EXACT [] synonym: "downregulation of RNA import into nucleus" EXACT [] synonym: "inhibition of RNA import into nucleus" NARROW [] synonym: "negative regulation of RNA import into cell nucleus" EXACT [] synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of RNA-nucleus import" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006404 ! RNA import into nucleus relationship: negatively_regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046830 name: positive regulation of RNA import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "activation of RNA import into nucleus" NARROW [] synonym: "positive regulation of RNA import into cell nucleus" EXACT [] synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of RNA-nucleus import" EXACT [] synonym: "stimulation of RNA import into nucleus" NARROW [] synonym: "up regulation of RNA import into nucleus" EXACT [] synonym: "up-regulation of RNA import into nucleus" EXACT [] synonym: "upregulation of RNA import into nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006404 ! RNA import into nucleus relationship: positively_regulates GO:0006404 ! RNA import into nucleus [Term] id: GO:0046831 name: regulation of RNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of RNA export from cell nucleus" EXACT [] synonym: "regulation of RNA export out of nucleus" EXACT [] synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of RNA-nucleus export" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006405 ! RNA export from nucleus relationship: regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046832 name: negative regulation of RNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of RNA export from nucleus" EXACT [] synonym: "down-regulation of RNA export from nucleus" EXACT [] synonym: "downregulation of RNA export from nucleus" EXACT [] synonym: "inhibition of RNA export from nucleus" NARROW [] synonym: "negative regulation of RNA export from cell nucleus" EXACT [] synonym: "negative regulation of RNA export out of nucleus" EXACT [] synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of RNA-nucleus export" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006405 ! RNA export from nucleus relationship: negatively_regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046833 name: positive regulation of RNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of RNA export from nucleus" NARROW [] synonym: "positive regulation of RNA export from cell nucleus" EXACT [] synonym: "positive regulation of RNA export out of nucleus" EXACT [] synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of RNA-nucleus export" EXACT [] synonym: "stimulation of RNA export from nucleus" NARROW [] synonym: "up regulation of RNA export from nucleus" EXACT [] synonym: "up-regulation of RNA export from nucleus" EXACT [] synonym: "upregulation of RNA export from nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006405 ! RNA export from nucleus relationship: positively_regulates GO:0006405 ! RNA export from nucleus [Term] id: GO:0046834 name: lipid phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732] is_a: GO:0016310 ! phosphorylation is_a: GO:0030258 ! lipid modification [Term] id: GO:0046835 name: carbohydrate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732] is_a: GO:0016310 ! phosphorylation is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0046836 name: glycolipid transport namespace: biological_process def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0046838 name: phosphorylated carbohydrate dephosphorylation namespace: biological_process def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732] is_a: GO:0016311 ! dephosphorylation is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0046839 name: phospholipid dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732] is_a: GO:0016311 ! dephosphorylation is_a: GO:0030258 ! lipid modification [Term] id: GO:0046841 name: trisporic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai] synonym: "trisporic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0046842 name: trisporic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai] synonym: "trisporic acid anabolism" EXACT [] synonym: "trisporic acid biosynthesis" EXACT [] synonym: "trisporic acid formation" EXACT [] synonym: "trisporic acid synthesis" EXACT [] is_a: GO:0046841 ! trisporic acid metabolic process [Term] id: GO:0046843 name: dorsal appendage formation namespace: biological_process def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0046844 name: chorion micropyle formation namespace: biological_process def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0046845 name: branched duct epithelial cell fate determination, open tracheal system namespace: biological_process def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] synonym: "branch cell fate determination" BROAD [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0046847 name: filopodium assembly namespace: biological_process def: "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] synonym: "filopodia biosynthesis" RELATED [] synonym: "filopodia formation" RELATED [] synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0046848 name: hydroxyapatite binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin." [PMID:2438276] synonym: "hydroxylapatite binding" EXACT [GOC:vk] is_a: GO:0005488 ! binding [Term] id: GO:0046849 name: bone remodeling namespace: biological_process def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators] synonym: "bone remodelling" EXACT [] xref: Wikipedia:Bone_remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0046850 name: regulation of bone remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046849 ! bone remodeling relationship: regulates GO:0046849 ! bone remodeling [Term] id: GO:0046851 name: negative regulation of bone remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "down regulation of bone remodeling" EXACT [] synonym: "down-regulation of bone remodeling" EXACT [] synonym: "downregulation of bone remodeling" EXACT [] synonym: "inhibition of bone remodeling" NARROW [] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046849 ! bone remodeling relationship: negatively_regulates GO:0046849 ! bone remodeling [Term] id: GO:0046852 name: positive regulation of bone remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "activation of bone remodeling" NARROW [] synonym: "stimulation of bone remodeling" NARROW [] synonym: "up regulation of bone remodeling" EXACT [] synonym: "up-regulation of bone remodeling" EXACT [] synonym: "upregulation of bone remodeling" EXACT [] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046849 ! bone remodeling relationship: positively_regulates GO:0046849 ! bone remodeling [Term] id: GO:0046853 name: obsolete inositol or phosphatidylinositol phosphorylation namespace: biological_process def: "OBSOLETE. The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732] comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. synonym: "inositol and derivative phosphorylation" RELATED [] synonym: "inositol or phosphatidylinositol phosphorylation" EXACT [] synonym: "myo-inositol and derivative phosphorylation" RELATED [] synonym: "myo-inositol or phosphatidyl-myo-inositol phosphorylation" NARROW [] is_obsolete: true consider: GO:0046854 consider: GO:0052746 [Term] id: GO:0046854 name: phosphatidylinositol phosphorylation namespace: biological_process alt_id: GO:0046837 def: "The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [ISBN:0198506732] synonym: "phosphatidylinositol phosphate biosynthetic process" NARROW [] synonym: "phosphatidylinositol phosphate phosphorylation" NARROW [] synonym: "phosphoinositide phosphorylation" NARROW [] synonym: "PIP biosynthesis" NARROW [] synonym: "PtdInsP biosynthesis" NARROW [] is_a: GO:0046488 ! phosphatidylinositol metabolic process is_a: GO:0046834 ! lipid phosphorylation [Term] id: GO:0046855 name: inositol phosphate dephosphorylation namespace: biological_process def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732] synonym: "myo-inositol phosphate dephosphorylation" NARROW [] is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation is_a: GO:0071545 ! inositol phosphate catabolic process [Term] id: GO:0046856 name: phosphatidylinositol dephosphorylation namespace: biological_process alt_id: GO:0046840 def: "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732] synonym: "phosphatidylinositol phosphate catabolic process" NARROW [] synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW [] synonym: "phosphoinositide dephosphorylation" EXACT [] synonym: "PIP catabolism" NARROW [] synonym: "PtdInsP catabolism" NARROW [] synonym: "PtdInsP dephosphorylation" NARROW [] is_a: GO:0046488 ! phosphatidylinositol metabolic process is_a: GO:0046839 ! phospholipid dephosphorylation [Term] id: GO:0046857 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.7.1 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0046858 name: chlorosome namespace: cellular_component def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732, PMID:14729689, PMID:15298919] xref: Wikipedia:Chlorosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0046859 name: hydrogenosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai] synonym: "hydrogenosome membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0042566 ! hydrogenosome [Term] id: GO:0046860 name: glycosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a glycosome." [GOC:ai] is_a: GO:0005778 ! peroxisomal membrane relationship: part_of GO:0020015 ! glycosome [Term] id: GO:0046861 name: glyoxysomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai] synonym: "glyoxysome membrane" EXACT [] is_a: GO:0005778 ! peroxisomal membrane [Term] id: GO:0046862 name: chromoplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0031898 ! chromoplast envelope [Term] id: GO:0046863 name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity namespace: molecular_function alt_id: GO:0018236 def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb] synonym: "ribulose-bisphosphate carboxylase activase activity" EXACT [] synonym: "rubisco activase activity" EXACT [] synonym: "rubisco activator" EXACT [] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0016984 ! ribulose-bisphosphate carboxylase activity [Term] id: GO:0046864 name: isoprenoid transport namespace: biological_process def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai] subset: goslim_pir is_a: GO:0006869 ! lipid transport [Term] id: GO:0046865 name: terpenoid transport namespace: biological_process def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai] is_a: GO:0046864 ! isoprenoid transport [Term] id: GO:0046866 name: tetraterpenoid transport namespace: biological_process def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai] is_a: GO:0046865 ! terpenoid transport [Term] id: GO:0046867 name: carotenoid transport namespace: biological_process def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] is_a: GO:0046866 ! tetraterpenoid transport [Term] id: GO:0046868 name: mesosome namespace: cellular_component def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [ISBN:0198506732, ISBN:0716731363] xref: Wikipedia:Mesosome is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0046869 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide namespace: biological_process def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT [] xref: RESID:AA0331 is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0046870 name: cadmium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with cadmium (Cd) ions." [GOC:ai] synonym: "cadmium binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0046871 name: N-acetylgalactosamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [GOC:ai, PMID:18384150] synonym: "N-acetylgalactosamine lectin" RELATED [] is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0046872 name: metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any metal ion." [GOC:ai] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "heavy metal binding" NARROW [] synonym: "metal binding" EXACT [] xref: MIPS_funcat:16.17 is_a: GO:0043169 ! cation binding [Term] id: GO:0046873 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0030001 ! metal ion transport [Term] id: GO:0046874 name: quinolinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] synonym: "quinolinate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0046875 name: ephrin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ephrin receptor." [GOC:ai] synonym: "Eph receptor binding" EXACT [] synonym: "ephrin" NARROW [] synonym: "GPI-linked ephrin" NARROW [] synonym: "transmembrane ephrin" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0046876 name: 3,4-didehydroretinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732] synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] is_a: GO:0005501 ! retinoid binding [Term] id: GO:0046877 name: regulation of saliva secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." [GOC:ai] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046541 ! saliva secretion relationship: regulates GO:0046541 ! saliva secretion [Term] id: GO:0046878 name: positive regulation of saliva secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai] synonym: "activation of saliva secretion" NARROW [] synonym: "stimulation of saliva secretion" NARROW [] synonym: "up regulation of saliva secretion" EXACT [] synonym: "up-regulation of saliva secretion" EXACT [] synonym: "upregulation of saliva secretion" EXACT [] is_a: GO:0046877 ! regulation of saliva secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046541 ! saliva secretion relationship: positively_regulates GO:0046541 ! saliva secretion [Term] id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046880 name: regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "regulation of follicle stimulating hormone secretion" EXACT [] synonym: "regulation of FSH secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046884 ! follicle-stimulating hormone secretion relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046881 name: positive regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "activation of follicle-stimulating hormone secretion" NARROW [] synonym: "positive regulation of follicle stimulating hormone secretion" EXACT [] synonym: "stimulation of follicle-stimulating hormone secretion" NARROW [] synonym: "up regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "upregulation of follicle-stimulating hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046882 name: negative regulation of follicle-stimulating hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] synonym: "down regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT [] synonym: "downregulation of follicle-stimulating hormone secretion" EXACT [] synonym: "inhibition of follicle-stimulating hormone secretion" NARROW [] synonym: "negative regulation of follicle stimulating hormone secretion" EXACT [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion [Term] id: GO:0046883 name: regulation of hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0023051 ! regulation of signaling is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046879 ! hormone secretion relationship: regulates GO:0046879 ! hormone secretion [Term] id: GO:0046884 name: follicle-stimulating hormone secretion namespace: biological_process def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] synonym: "follicle stimulating hormone secretion" EXACT [] synonym: "follitropin secretion" EXACT [] synonym: "FSH secretion" EXACT [] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0046885 name: regulation of hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "regulation of hormone anabolism" EXACT [] synonym: "regulation of hormone biosynthesis" EXACT [] synonym: "regulation of hormone formation" EXACT [] synonym: "regulation of hormone synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042446 ! hormone biosynthetic process relationship: regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0046886 name: positive regulation of hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "activation of hormone biosynthetic process" NARROW [] synonym: "positive regulation of hormone anabolism" EXACT [] synonym: "positive regulation of hormone biosynthesis" EXACT [] synonym: "positive regulation of hormone formation" EXACT [] synonym: "positive regulation of hormone synthesis" EXACT [] synonym: "stimulation of hormone biosynthetic process" NARROW [] synonym: "up regulation of hormone biosynthetic process" EXACT [] synonym: "up-regulation of hormone biosynthetic process" EXACT [] synonym: "upregulation of hormone biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042446 ! hormone biosynthetic process relationship: positively_regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0046887 name: positive regulation of hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "activation of hormone secretion" NARROW [] synonym: "stimulation of hormone secretion" NARROW [] synonym: "up regulation of hormone secretion" EXACT [] synonym: "up-regulation of hormone secretion" EXACT [] synonym: "upregulation of hormone secretion" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046879 ! hormone secretion relationship: positively_regulates GO:0046879 ! hormone secretion [Term] id: GO:0046888 name: negative regulation of hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "down regulation of hormone secretion" EXACT [] synonym: "down-regulation of hormone secretion" EXACT [] synonym: "downregulation of hormone secretion" EXACT [] synonym: "inhibition of hormone secretion" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046879 ! hormone secretion relationship: negatively_regulates GO:0046879 ! hormone secretion [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008610 ! lipid biosynthetic process relationship: positively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008610 ! lipid biosynthetic process relationship: regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0046891 name: peptidyl-cysteine S-carbamoylation namespace: biological_process def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332] xref: RESID:AA0332 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0046892 name: peptidyl-S-carbamoyl-L-cysteine dehydration namespace: biological_process def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333] synonym: "formation of peptidyl-S-cyanocysteine" EXACT [] synonym: "formation of peptidyl-serine thiocyanate ester" EXACT [] xref: RESID:AA0333 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018249 ! protein dehydration [Term] id: GO:0046893 name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation namespace: biological_process def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334] xref: RESID:AA0334 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0046894 name: enzyme active site formation via S-amidino-L-cysteine namespace: biological_process def: "Active site formation via the transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098823 ! peptidyl-cysteine modification to S-amindino-L-cysteine [Term] id: GO:0046895 name: N-terminal peptidyl-isoleucine methylation namespace: biological_process def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336] xref: RESID:AA0336 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0046896 name: N-terminal peptidyl-leucine methylation namespace: biological_process def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337] xref: RESID:AA0337 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018204 ! peptidyl-leucine modification [Term] id: GO:0046897 name: N-terminal peptidyl-tyrosine methylation namespace: biological_process def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338] xref: RESID:AA0338 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0046898 name: response to cycloheximide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:ef, ISBN:0198506732] synonym: "response to actidione" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0060992 ! response to fungicide is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0046899 name: nucleoside triphosphate adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10] synonym: "GTP:AMP phosphotransferase" NARROW [] synonym: "guanosine triphosphate-adenylate kinase" NARROW [] synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10] synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT [] synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT [] synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10] xref: EC:2.7.4.10 xref: MetaCyc:2.7.4.10-RXN xref: Reactome:R-HSA-1008248 "Adenylate Kinase 3 is a GTP-AMP phosphotransferase" xref: RHEA:13749 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0046900 name: tetrahydrofolylpolyglutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT [] synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT [] synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process [Term] id: GO:0046901 name: tetrahydrofolylpolyglutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] synonym: "folic acid-containing compound polyglutamylation" BROAD [GOC:dhl] synonym: "tetrahydrofolate polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT [] synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT [] synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT [] synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT [] synonym: "tetrahydrofolylpolyglutamate formation" EXACT [] synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT [] synonym: "THF polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process [Term] id: GO:0046902 name: regulation of mitochondrial membrane permeability namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] synonym: "regulation of mitochondrial envelope permeability" RELATED [] synonym: "regulation of transport across mitochondrial membrane" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0090559 ! regulation of membrane permeability relationship: part_of GO:0006839 ! mitochondrial transport [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir xref: MIPS_funcat:20.09.16 is_a: GO:0006810 ! transport [Term] id: GO:0046904 name: calcium oxalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544] is_a: GO:0005488 ! binding [Term] id: GO:0046905 name: phytoene synthase activity namespace: molecular_function def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + diphosphate." [GOC:ai, PMID:12641468] comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups relationship: part_of GO:0016120 ! carotene biosynthetic process [Term] id: GO:0046906 name: tetrapyrrole binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "porphyrin binding" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046908 name: obsolete negative regulation of crystal formation namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai] comment: This term was made obsolete because a more appropriate term was created. synonym: "negative regulation of crystal formation" EXACT [] synonym: "negative regulation of mineralization" RELATED [] is_obsolete: true replaced_by: GO:0050801 [Term] id: GO:0046909 name: obsolete intermembrane transport namespace: biological_process def: "OBSOLETE. The directed movement of substances between any membrane of a cell, including the plasma membrane and its regions." [GOC:ai, GOC:pr, PMID:10671554] comment: The reason for obsoletion is that this term was incorrectly named, defined, and placed in the ontology, and thus had been used to annotate two unrelated processes of [intermembrane lipid transfer] and processes related to [vesicular transport]. It was also inappropriately used as the parent term for [protein transport from ciliary membrane to plasma membrane], which has already been moved to an appropriate location as a child of [protein transport within lipid bilayer]. is_obsolete: true consider: GO:0016192 consider: GO:0120009 [Term] id: GO:0046910 name: pectinesterase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981] comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'. is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0030599 ! pectinesterase activity [Term] id: GO:0046911 name: metal chelating activity namespace: molecular_function def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [ISBN:0198506732, ISBN:0716731363] synonym: "heavy metal chelation" NARROW [] synonym: "metal chelation" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0046912 name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] xref: EC:2.3.3 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0046914 name: transition metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0046915 name: transition metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:0000041 ! transition metal ion transport [Term] id: GO:0046916 name: cellular transition metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0046917 name: triphosphoribosyl-dephospho-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.4.2.52] synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.4.2.52] synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [] synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT [] synonym: "CitG activity" RELATED [] xref: EC:2.4.2.52 xref: MetaCyc:2.7.8.25-RXN xref: RHEA:15117 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0046918 name: N-terminal peptidyl-glycine N-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine." [RESID:AA0339] comment: Palmitoylation of glycine only occurs when glycine is at the N-terminal position of a protein. xref: RESID:AA0339 is_a: GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0046919 name: pyruvyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0046920 name: alpha-(1->3)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai] synonym: "alpha(1,3)-fucosyltransferase activity" EXACT [] synonym: "alpha-(1,3)-fucosyltransferase activity" EXACT [] synonym: "alpha-1,3-fucosyltransferase activity" EXACT [] xref: Reactome:R-HSA-9603984 "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX" xref: Reactome:R-HSA-9605609 "FUT3 transfers Fuc to Type 1 MSGG to form sLeA" xref: Reactome:R-HSA-9605644 "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA" xref: Reactome:R-HSA-9605682 "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX" is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0046921 name: alpha-(1->6)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai] synonym: "alpha(1,6)-fucosyltransferase activity" EXACT [] synonym: "alpha-(1,6)-fucosyltransferase activity" EXACT [] synonym: "alpha-1,6-fucosyltransferase activity" EXACT [] is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0046922 name: peptide-O-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] xref: EC:2.4.1.221 xref: MetaCyc:2.4.1.221-RXN xref: Reactome:R-HSA-1912349 "Fucosylation of Pre-NOTCH by POFUT1" xref: Reactome:R-HSA-5173192 "POFUT2 transfers fucose to TSR domain-containing proteins" is_a: GO:0008417 ! fucosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0036066 ! protein O-linked fucosylation [Term] id: GO:0046923 name: ER retention sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] synonym: "endoplasmic reticulum retention sequence binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0046924 name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine namespace: biological_process def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340] xref: RESID:AA0340 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0046925 name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine namespace: biological_process def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341] xref: RESID:AA0341 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0046926 name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine namespace: biological_process def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342] xref: RESID:AA0342 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046927 name: peptidyl-threonine racemization namespace: biological_process def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888] is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0046928 name: regulation of neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007269 ! neurotransmitter secretion relationship: regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0046929 name: negative regulation of neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] synonym: "conotoxin activity" NARROW [] synonym: "down regulation of neurotransmitter secretion" EXACT [] synonym: "down-regulation of neurotransmitter secretion" EXACT [] synonym: "downregulation of neurotransmitter secretion" EXACT [] synonym: "inhibition of neurotransmitter secretion" NARROW [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007269 ! neurotransmitter secretion relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0046930 name: pore complex namespace: cellular_component def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] synonym: "channel-forming toxin activity" RELATED [] synonym: "pore" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0046931 name: pore complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah] comment: See also the cellular component term 'pore complex ; GO:0046930'. synonym: "pore biosynthesis" EXACT [] synonym: "pore complex biogenesis" RELATED [GOC:mah] synonym: "pore formation" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0046932 name: sodium-transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2] synonym: "sodium-translocating F-type ATPase activity" EXACT [] synonym: "sodium-transporting two-sector ATPase activity" EXACT [] xref: MetaCyc:3.6.3.15-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [Term] id: GO:0046933 name: proton-transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:7.1.2.2, TC:3.A.2.1.1] synonym: "H+-transporting ATP synthase activity" EXACT [EC:7.1.2.2] synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] xref: MetaCyc:ATPSYN-RXN xref: Reactome:R-HSA-164832 "ATPase synthesizes ATP" xref: RHEA:57722 is_a: GO:0015252 ! proton channel activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0046934 name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21292] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153] xref: EC:2.7.1.153 xref: KEGG_REACTION:R04545 xref: MetaCyc:2.7.1.153-RXN xref: Reactome:R-HSA-1226014 "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1250370 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers" xref: Reactome:R-HSA-1250462 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3" xref: Reactome:R-HSA-1306957 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR" xref: Reactome:R-HSA-1306979 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1" xref: Reactome:R-HSA-1676048 "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane" xref: Reactome:R-HSA-177939 "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)" xref: Reactome:R-HSA-1839091 "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-1839107 "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3." xref: Reactome:R-HSA-186800 "PI3K catalyses the phosphorylation of PIP2 to PIP3" xref: Reactome:R-HSA-198266 "PI3K produces PIP3 and other phosphatidyl inositides" xref: Reactome:R-HSA-202365 "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-2029271 "PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-2076220 "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3" xref: Reactome:R-HSA-2316434 "PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-2394007 "PI3K gain of function mutants phosphorylate PIP2 to PIP3" xref: Reactome:R-HSA-2424480 "PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-2730870 "Phosphorylation of PIP2 to PIP3 by PI3K" xref: Reactome:R-HSA-389158 "CD28 bound PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-392300 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3" xref: Reactome:R-HSA-437162 "PI3K alpha, beta, gamma convert PIP2 to PIP3" xref: Reactome:R-HSA-5218819 "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5637801 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII" xref: Reactome:R-HSA-5654690 "FGFR1-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654692 "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654697 "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654701 "FGFR2-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654705 "FGFR3-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654709 "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654714 "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5654717 "FGFR4-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5655235 "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5655289 "Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5655290 "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-5655323 "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3" xref: Reactome:R-HSA-8853323 "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity" xref: RHEA:21292 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity [Term] id: GO:0046935 name: 1-phosphatidylinositol-3-kinase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai] comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. synonym: "1-phosphatidylinositol 3-kinase regulator activity" EXACT [] synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW [] is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity relationship: regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity [Term] id: GO:0046936 name: deoxyadenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai] synonym: "deoxyadenosine deaminase reaction" EXACT [] xref: MetaCyc:ADDALT-RXN is_a: GO:0019239 ! deaminase activity [Term] id: GO:0046937 name: phytochelatin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732] synonym: "cadystin metabolic process" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "cadystin metabolism" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "phytochelatin metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0046938 name: phytochelatin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732] synonym: "cadystin biosynthetic process" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "phytochelatin anabolism" EXACT [] synonym: "phytochelatin biosynthesis" EXACT [] synonym: "phytochelatin formation" EXACT [] synonym: "phytochelatin synthesis" EXACT [] is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046937 ! phytochelatin metabolic process [Term] id: GO:0046939 name: nucleotide phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] is_a: GO:0016310 ! phosphorylation [Term] id: GO:0046940 name: nucleoside monophosphate phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0046941 name: azetidine-2-carboxylic acid acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0046944 name: protein carbamoylation namespace: biological_process def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai] synonym: "protein amino acid carbamoylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0046945 name: N-terminal peptidyl-alanine N-carbamoylation namespace: biological_process def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343] synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED [] xref: RESID:AA0343 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0046944 ! protein carbamoylation is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation [Term] id: GO:0046946 name: hydroxylysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [ISBN:0198506732, PubChem_Compound:1029] synonym: "hydroxylysine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0046947 name: hydroxylysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732] synonym: "hydroxylysine anabolism" EXACT [] synonym: "hydroxylysine biosynthesis" EXACT [] synonym: "hydroxylysine formation" EXACT [] synonym: "hydroxylysine synthesis" EXACT [] is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046946 ! hydroxylysine metabolic process [Term] id: GO:0046948 name: hydroxylysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732] synonym: "hydroxylysine breakdown" EXACT [] synonym: "hydroxylysine catabolism" EXACT [] synonym: "hydroxylysine degradation" EXACT [] is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046946 ! hydroxylysine metabolic process [Term] id: GO:0046949 name: fatty-acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] synonym: "fatty acyl CoA biosynthetic process" EXACT [] synonym: "fatty-acyl-CoA anabolism" EXACT [] synonym: "fatty-acyl-CoA biosynthesis" EXACT [] synonym: "fatty-acyl-CoA formation" EXACT [] synonym: "fatty-acyl-CoA synthesis" EXACT [] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process [Term] id: GO:0046950 name: cellular ketone body metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732] subset: goslim_pir synonym: "cellular ketone body metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0046951 name: ketone body biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732] synonym: "ketone body anabolism" EXACT [] synonym: "ketone body biosynthesis" EXACT [] synonym: "ketone body formation" EXACT [] synonym: "ketone body synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046950 ! cellular ketone body metabolic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process is_a: GO:1902224 ! ketone body metabolic process [Term] id: GO:0046952 name: ketone body catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732] synonym: "ketolysis" EXACT [MetaCyc:PWY66-368] synonym: "ketone body breakdown" EXACT [] synonym: "ketone body catabolism" EXACT [Reactome:R-HSA-77108] synonym: "ketone body degradation" EXACT [] synonym: "utilization of ketone bodies" EXACT [Reactome:R-HSA-77108] xref: MetaCyc:PWY66-368 xref: Reactome:R-HSA-77108 is_a: GO:0042737 ! drug catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046950 ! cellular ketone body metabolic process is_a: GO:1901569 ! fatty acid derivative catabolic process is_a: GO:1902224 ! ketone body metabolic process [Term] id: GO:0046956 name: positive phototaxis namespace: biological_process alt_id: GO:0046954 def: "The directed movement of a cell or organism towards a source of light." [GOC:ai] synonym: "positive phototactic behavior" EXACT [] synonym: "positive phototactic behaviour" EXACT [] synonym: "positive taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052128 ! positive energy taxis [Term] id: GO:0046957 name: negative phototaxis namespace: biological_process alt_id: GO:0046955 def: "The directed movement of a cell or organism away from a source of light." [GOC:ai] synonym: "negative phototactic behavior" EXACT [] synonym: "negative phototactic behaviour" EXACT [] synonym: "negative taxis in response to light" EXACT [] is_a: GO:0042331 ! phototaxis is_a: GO:0052129 ! negative energy taxis [Term] id: GO:0046958 name: nonassociative learning namespace: biological_process def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089] synonym: "unconditional response" EXACT [] is_a: GO:0007612 ! learning [Term] id: GO:0046959 name: habituation namespace: biological_process def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] xref: Wikipedia:Habituation is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0046960 name: sensitization namespace: biological_process def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] xref: Wikipedia:Sensitization is_a: GO:0046958 ! nonassociative learning [Term] id: GO:0046961 name: proton-transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14] synonym: "ATP synthase activity" BROAD [EC:3.6.3.14] synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14] synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14] synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14] synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14] synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14] synonym: "F1-ATPase" NARROW [EC:3.6.3.14] synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14] synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14] synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14] synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14] synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14] xref: MetaCyc:ATPSYN-RXN xref: RHEA:57721 is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [Term] id: GO:0046962 name: sodium-transporting ATPase activity, rotational mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15] synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15] synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145] synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15] synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15] synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15] synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15] synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT [] synonym: "sodium-translocating F-type ATPase activity" NARROW [] synonym: "sodium-translocating V-type ATPase activity" NARROW [] synonym: "sodium-transporting two-sector ATPase activity" NARROW [] synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15] synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15] xref: MetaCyc:3.6.3.15-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [Term] id: GO:0046963 name: 3'-phosphoadenosine 5'-phosphosulfate transport namespace: biological_process def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT [] synonym: "PAPS transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0046964 name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732] synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT [] synonym: "PAPS transporter activity" EXACT [] xref: Reactome:R-HSA-741449 "SLC35B2,3 transport cytosolic PAPS to Golgi lumen" is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport [Term] id: GO:0046965 name: retinoid X receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a retinoid X receptor." [GOC:ai] synonym: "RXR binding" EXACT [] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0042974 ! retinoic acid receptor binding [Term] id: GO:0046966 name: thyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a thyroid hormone receptor." [GOC:ai] synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0046967 name: cytosol to endoplasmic reticulum transport namespace: biological_process def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai] synonym: "cytosol to endoplasmic reticulum transport" EXACT [] synonym: "cytosol to ER transport" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0046968 name: peptide antigen transport namespace: biological_process def: "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0015833 ! peptide transport relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0046969 name: NAD-dependent histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] xref: Reactome:R-HSA-9604829 "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters" is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific) [Term] id: GO:0046970 name: NAD-dependent histone deacetylase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [EC:3.5.1.17, GOC:vw, RHEA:24548] is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific) [Term] id: GO:0046972 name: histone acetyltransferase activity (H4-K16 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48] synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT [] is_a: GO:0010485 ! H4 histone acetyltransferase activity relationship: part_of GO:0043984 ! histone H4-K16 acetylation [Term] id: GO:0046973 name: obsolete histone lysine N-methyltransferase activity (H3-K24 specific) namespace: molecular_function def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai] comment: This term was made obsolete because there is no lysine at position 24 of histone H3. synonym: "histone lysine N-methyltransferase activity (H3-K24 specific)" EXACT [] is_obsolete: true consider: GO:0042800 [Term] id: GO:0046974 name: histone methyltransferase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT [] synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah] xref: Reactome:R-HSA-427336 "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9." xref: Reactome:R-HSA-427527 "eNoSC dimethylates histone H3 at lysine-9" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0046975 name: histone methyltransferase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT [] synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0046976 name: histone methyltransferase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai] synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT [] synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah] xref: Reactome:R-HSA-3240295 "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0070734 ! histone H3-K27 methylation [Term] id: GO:0046977 name: TAP binding namespace: molecular_function def: "Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832] is_a: GO:0005515 ! protein binding [Term] id: GO:0046978 name: TAP1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] is_a: GO:0046977 ! TAP binding [Term] id: GO:0046979 name: TAP2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] is_a: GO:0046977 ! TAP binding [Term] id: GO:0046980 name: tapasin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855] synonym: "TAP binding protein binding" EXACT [HGNC:11566] synonym: "TAPBP binding" RELATED [HGNC:11566] is_a: GO:0005515 ! protein binding [Term] id: GO:0046981 name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651] synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [] is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0046982 name: protein heterodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] subset: goslim_chembl is_a: GO:0046983 ! protein dimerization activity [Term] id: GO:0046983 name: protein dimerization activity namespace: molecular_function def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0046984 name: regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "regulation of haemoglobin biosynthesis" EXACT [] synonym: "regulation of haemoglobin biosynthetic process" EXACT [] synonym: "regulation of hemoglobin anabolism" EXACT [] synonym: "regulation of hemoglobin biosynthesis" EXACT [] synonym: "regulation of hemoglobin formation" EXACT [] synonym: "regulation of hemoglobin synthesis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042541 ! hemoglobin biosynthetic process relationship: regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046985 name: positive regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "activation of hemoglobin biosynthetic process" NARROW [] synonym: "positive regulation of haemoglobin biosynthesis" EXACT [] synonym: "positive regulation of haemoglobin biosynthetic process" EXACT [] synonym: "positive regulation of hemoglobin anabolism" EXACT [] synonym: "positive regulation of hemoglobin biosynthesis" EXACT [] synonym: "positive regulation of hemoglobin formation" EXACT [] synonym: "positive regulation of hemoglobin synthesis" EXACT [] synonym: "stimulation of hemoglobin biosynthetic process" NARROW [] synonym: "up regulation of hemoglobin biosynthetic process" EXACT [] synonym: "up-regulation of hemoglobin biosynthetic process" EXACT [] synonym: "upregulation of hemoglobin biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042541 ! hemoglobin biosynthetic process relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046986 name: negative regulation of hemoglobin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] synonym: "down regulation of hemoglobin biosynthetic process" EXACT [] synonym: "down-regulation of hemoglobin biosynthetic process" EXACT [] synonym: "downregulation of hemoglobin biosynthetic process" EXACT [] synonym: "inhibition of hemoglobin biosynthetic process" NARROW [] synonym: "negative regulation of haemoglobin biosynthesis" EXACT [] synonym: "negative regulation of haemoglobin biosynthetic process" EXACT [] synonym: "negative regulation of hemoglobin anabolism" EXACT [] synonym: "negative regulation of hemoglobin biosynthesis" EXACT [] synonym: "negative regulation of hemoglobin formation" EXACT [] synonym: "negative regulation of hemoglobin synthesis" EXACT [] is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process [Term] id: GO:0046987 name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT [] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046988 name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046989 name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0046990 name: N-hydroxyarylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN] synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118] xref: EC:2.3.1.118 xref: MetaCyc:2.3.1.118-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0046992 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai] comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW [] xref: EC:1.21 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0046993 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai] xref: EC:1.21.3 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0046994 name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl] xref: EC:1.12.5 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0046995 name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai] xref: EC:1.12.98 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0046996 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated" RELATED [] xref: EC:1.14.21 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0046997 name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] xref: EC:1.5.8 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0046998 name: (S)-usnate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH." [EC:1.1.1.199, RHEA:21876] synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199] synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199] xref: EC:1.1.1.199 xref: KEGG_REACTION:R07345 xref: MetaCyc:1.1.1.199-RXN xref: RHEA:21876 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0046999 name: regulation of conjugation namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000746 ! conjugation relationship: regulates GO:0000746 ! conjugation [Term] id: GO:0047000 name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH." [EC:1.1.1.126, RHEA:15109] synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126] synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126] xref: EC:1.1.1.126 xref: KEGG_REACTION:R01543 xref: MetaCyc:1.1.1.126-RXN xref: RHEA:15109 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047001 name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN] synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127] synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127] xref: EC:1.1.1.127 xref: MetaCyc:1.1.1.127-RXN xref: RHEA:24232 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047002 name: L-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH." [EC:1.1.1.13, RHEA:21356] synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT [] xref: EC:1.1.1.13 xref: KEGG_REACTION:R02441 xref: MetaCyc:1.1.1.13-RXN xref: RHEA:21356 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047003 name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.134, RHEA:23648] synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134] synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134] synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] xref: EC:1.1.1.134 xref: KEGG_REACTION:R02776 xref: MetaCyc:1.1.1.134-RXN xref: RHEA:23648 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047004 name: UDP-N-acetylglucosamine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate." [EC:1.1.1.136, RHEA:13325] synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136] synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] xref: EC:1.1.1.136 xref: KEGG_REACTION:R00421 xref: MetaCyc:1.1.1.136-RXN xref: RHEA:13325 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047005 name: 16-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN] synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147] synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147] xref: EC:1.1.1.147 xref: MetaCyc:1.1.1.147-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047006 name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] synonym: "20alpha-HSD" RELATED [EC:1.1.1.149] synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149] synonym: "20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149] synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149] xref: EC:1.1.1.149 xref: MetaCyc:1.1.1.149-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047007 name: pregnan-21-ol dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al." [EC:1.1.1.150, RHEA:11448] synonym: "21-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.50] synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" BROAD [EC:1.1.1.150] xref: EC:1.1.1.150 xref: KEGG_REACTION:R03043 xref: MetaCyc:1.1.1.150-RXN xref: RHEA:11448 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047008 name: pregnan-21-ol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al." [EC:1.1.1.151, RHEA:23712] synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxysteroid dehydrogenase (NADP+) activity" BROAD [EC:1.1.1.151] synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" BROAD [EC:1.1.1.151] synonym: "NADP-21-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.151] xref: EC:1.1.1.151 xref: KEGG_REACTION:R03044 xref: MetaCyc:1.1.1.151-RXN xref: RHEA:23712 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047009 name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN] synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] xref: EC:1.1.1.152 xref: MetaCyc:1.1.1.152-RXN xref: RHEA:10356 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047010 name: hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH." [EC:1.1.1.166, RHEA:10516] synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166] synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166] xref: EC:1.1.1.166 xref: KEGG_REACTION:R05315 xref: MetaCyc:1.1.1.166-RXN xref: RHEA:10516 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047011 name: 2-dehydropantolactone reductase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN] synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168] synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] xref: EC:1.1.1.168 xref: MetaCyc:1.1.1.168-RXN is_a: GO:0036441 ! 2-dehydropantolactone reductase activity [Term] id: GO:0047012 name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN] synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT [] synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170] synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170] xref: EC:1.1.1.170 xref: MetaCyc:1.1.1.170-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047013 name: cholate 12-alpha dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.176, RHEA:14129] synonym: "12-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.176] synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] xref: EC:1.1.1.176 xref: KEGG_REACTION:R02793 xref: MetaCyc:1.1.1.176-RXN xref: RHEA:14129 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047014 name: glycerol-3-phosphate 1-dehydrogenase [NADP+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH." [EC:1.1.1.177, RHEA:19773] synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177] synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177] xref: EC:1.1.1.177 xref: KEGG_REACTION:R00845 xref: MetaCyc:1.1.1.177-RXN xref: RHEA:19773 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047015 name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN] synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178] synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178] xref: EC:1.1.1.178 xref: MetaCyc:1.1.1.178-RXN xref: RHEA:13281 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047016 name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN] synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181] synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181] xref: EC:1.1.1.181 xref: MetaCyc:1.1.1.181-RXN xref: RHEA:11896 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047017 name: prostaglandin-F synthase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188] synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188] synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188] synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188] synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188] synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188] xref: EC:1.1.1.188 xref: MetaCyc:1.1.1.188-RXN xref: RHEA:10140 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047018 name: indole-3-acetaldehyde reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH." [EC:1.1.1.190, RHEA:14873] synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190] xref: EC:1.1.1.190 xref: KEGG_REACTION:R02679 xref: MetaCyc:1.1.1.190-RXN xref: RHEA:14873 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047019 name: indole-3-acetaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH." [EC:1.1.1.191, RHEA:17037] synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191] xref: EC:1.1.1.191 xref: KEGG_REACTION:R02680 xref: MetaCyc:1.1.1.191-RXN xref: RHEA:17037 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047020 name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196] synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196] synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196] xref: EC:1.1.1.196 xref: MetaCyc:1.1.1.196-RXN xref: RHEA:20744 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047021 name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH." [EC:1.1.1.197, RHEA:11636] synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197] synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197] xref: EC:1.1.1.197 xref: KEGG_REACTION:R04552 xref: MetaCyc:1.1.1.197-RXN xref: RHEA:11636 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047022 name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN] synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201] synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] xref: EC:1.1.1.201 xref: MetaCyc:1.1.1.201-RXN xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047023 name: androsterone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" BROAD [EC:1.1.1.209] xref: EC:1.1.1.209 xref: MetaCyc:1.1.1.209-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047024 name: 5alpha-androstane-3beta,17beta-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH." [EC:1.1.1.210, RHEA:16297] synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] synonym: "3-beta-HSD activity" RELATED [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210] synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210] synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210] synonym: "progesterone reductase activity" RELATED [EC:1.1.1.210] xref: EC:1.1.1.210 xref: KEGG_REACTION:R04344 xref: MetaCyc:1.1.1.210-RXN xref: RHEA:16297 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047025 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN] synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT [] synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212] synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212] xref: EC:1.1.1.212 xref: MetaCyc:1.1.1.212-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047026 name: androsterone dehydrogenase (A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN] synonym: "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity" BROAD [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213] xref: EC:1.1.1.213 xref: MetaCyc:1.1.1.213-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity [Term] id: GO:0047027 name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH." [EC:1.1.1.217, RHEA:16405] synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217] synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217] xref: EC:1.1.1.217 xref: KEGG_REACTION:R04370 xref: MetaCyc:1.1.1.217-RXN xref: RHEA:16405 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047028 name: 6-pyruvoyltetrahydropterin 2'-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN] synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220] synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220] synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220] synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220] xref: EC:1.1.1.220 xref: MetaCyc:1.1.1.220-RXN xref: RHEA:11772 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047029 name: (R)-4-hydroxyphenyllactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN] synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222] synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222] synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222] xref: EC:1.1.1.222 xref: MetaCyc:1.1.1.222-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047030 name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH." [EC:1.1.1.226, RHEA:17429] synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226] synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226] xref: EC:1.1.1.226 xref: KEGG_REACTION:R04307 xref: MetaCyc:1.1.1.226-RXN xref: RHEA:17429 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047031 name: diethyl 2-methyl-3-oxosuccinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH." [EC:1.1.1.229, RHEA:21008] synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229] xref: EC:1.1.1.229 xref: KEGG_REACTION:R04387 xref: MetaCyc:1.1.1.229-RXN xref: RHEA:21008 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047032 name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH." [EC:1.1.1.230, RHEA:20816] synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230] synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230] xref: EC:1.1.1.230 xref: KEGG_REACTION:R04099 xref: MetaCyc:1.1.1.230-RXN xref: RHEA:20816 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047033 name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH." [EC:1.1.1.231, RHEA:21420] synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231] synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231] synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231] xref: EC:1.1.1.231 xref: KEGG_REACTION:R03520 xref: MetaCyc:1.1.1.231-RXN xref: RHEA:21420 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047034 name: 15-hydroxyicosatetraenoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN] synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232] synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232] xref: EC:1.1.1.232 xref: MetaCyc:1.1.1.232-RXN xref: Reactome:R-HSA-2161789 "15S-HETE is oxidised to 15-oxoETE by 15-HEDH" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047035 name: testosterone dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0050327 def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63] synonym: "17beta-HSD" RELATED [EC:1.1.1.63] synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63] synonym: "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.239] synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239] synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" BROAD [EC:1.1.1.239] synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.239] synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.239] synonym: "testosterone 17-beta-dehydrogenase (NAD+) activity" EXACT [] synonym: "testosterone 17b-dehydrogenase activity" EXACT [] synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63] xref: EC:1.1.1.239 xref: KEGG_REACTION:R01836 xref: MetaCyc:1.1.1.239-RXN xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN xref: RHEA:14929 xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+) is_a: GO:0030283 ! testosterone dehydrogenase [NAD(P)] activity [Term] id: GO:0047036 name: codeinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH." [EC:1.1.1.247, RHEA:19209] synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247] xref: EC:1.1.1.247 xref: KEGG_REACTION:R05124 xref: MetaCyc:1.1.1.247-RXN xref: RHEA:19209 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047037 name: salutaridine reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine." [EC:1.1.1.248, RHEA:10108] synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248] xref: EC:1.1.1.248 xref: KEGG_REACTION:R04697 xref: MetaCyc:1.1.1.248-RXN xref: RHEA:10108 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047038 name: D-arabinitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.250, RHEA:17389] synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250] synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250] xref: EC:1.1.1.250 xref: KEGG_REACTION:R07134 xref: MetaCyc:1.1.1.250-RXN xref: RHEA:17389 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047039 name: tetrahydroxynaphthalene reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN] synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252] synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252] xref: EC:1.1.1.252 xref: MetaCyc:1.1.1.252-RXN xref: RHEA:21908 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047040 name: pteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH." [EC:1.5.1.33, RHEA:19509] comment: Note that this function was formerly EC:1.1.1.253. synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e] synonym: "PTR1" RELATED [EC:1.5.1.33] synonym: "ptr1 activity" NARROW [EC:1.5.1.33e] xref: EC:1.5.1.33 xref: KEGG_REACTION:R01812 xref: MetaCyc:1.1.1.253-RXN xref: RHEA:19509 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047041 name: (S)-carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.254, RHEA:11556] synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254] synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254] xref: EC:1.1.1.254 xref: KEGG_REACTION:R01921 xref: MetaCyc:1.1.1.254-RXN xref: RHEA:11556 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047042 name: androsterone dehydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] synonym: "3-alpha-HSD activity" RELATED [EC:1.1.1.50] synonym: "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity" BROAD [EC:1.1.1.50] synonym: "3alpha-HSD" RELATED [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" BROAD [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.50] synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" BROAD [EC:1.1.1.50] synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] xref: EC:1.1.1.50 xref: MetaCyc:1.1.1.50-RXN xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific) is_a: GO:0047023 ! androsterone dehydrogenase activity [Term] id: GO:0047043 name: 3-alpha-hydroxycholanate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.52, RHEA:19585] synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52] synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52] synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52] xref: EC:1.1.1.52 xref: KEGG_REACTION:R04139 xref: MetaCyc:1.1.1.52-RXN xref: RHEA:19585 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047044 name: androstan-3-alpha,17-beta-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] synonym: "(R)-20-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] synonym: "20beta-HSD" RELATED [EC:1.1.1.53] synonym: "20beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] synonym: "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.53] synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" BROAD [EC:1.1.1.53] synonym: "cortisone reductase activity" RELATED [EC:1.1.1.53] synonym: "dehydrogenase, 20beta-hydroxy steroid" BROAD [EC:1.1.1.53] synonym: "delta4-3-ketosteroid hydrogenase activity" BROAD [EC:1.1.1.53] synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] xref: EC:1.1.1.53 xref: MetaCyc:1.1.1.53-RXN xref: RHEA:22400 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047045 name: testosterone 17-beta-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64] synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64] synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64] xref: EC:1.1.1.64 xref: KEGG_REACTION:R01838 xref: MetaCyc:1.1.1.64-RXN xref: RHEA:14981 xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047046 name: homoisocitrate dehydrogenase activity namespace: molecular_function alt_id: GO:0047984 def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN] comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT [] synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87] xref: EC:1.1.1.87 xref: MetaCyc:1.1.1.87-RXN xref: RHEA:11900 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047047 name: oxaloglycolate reductase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN] synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92] xref: EC:1.1.1.92 xref: MetaCyc:1.1.1.92-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047048 name: 3-hydroxybenzyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH." [EC:1.1.1.97, RHEA:22340] synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97] synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97] xref: EC:1.1.1.97 xref: KEGG_REACTION:R04136 xref: MetaCyc:1.1.1.97-RXN xref: RHEA:22340 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047049 name: (R)-2-hydroxy-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.98, RHEA:15949] synonym: "(R)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98] synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98] xref: EC:1.1.1.98 xref: KEGG_REACTION:R03021 xref: MetaCyc:1.1.1.98-RXN xref: RHEA:15949 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047050 name: (S)-2-hydroxy-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.99, RHEA:11384] synonym: "(S)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99] synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99] synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99] synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99] xref: EC:1.1.1.99 xref: KEGG_REACTION:R03022 xref: MetaCyc:1.1.1.99-RXN xref: RHEA:11384 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047051 name: D-lactate dehydrogenase (cytochrome c-553) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN] synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5] xref: EC:1.1.2.5 xref: MetaCyc:1.1.2.5-RXN is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0047052 name: (S)-stylopine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-cheilanthifoline + H(+) + NADPH + O(2) = (S)-stylopine + 2 H(2)O + NADP(+)." [EC:1.14.19.64, RHEA:13773] synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.19.64] synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.19.64] xref: EC:1.14.19.64 xref: KEGG_REACTION:R04690 xref: MetaCyc:1.1.3.32-RXN xref: RHEA:13773 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0047053 name: (S)-cheilanthifoline synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + H(+) + NADPH + O(2) = (S)-cheilanthifoline + 2 H(2)O + NADP(+)." [EC:1.14.19.65, RHEA:20485] synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT [] synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.19.65] xref: EC:1.14.19.65 xref: KEGG_REACTION:R03834 xref: MetaCyc:1.14.21.2-RXN xref: RHEA:20485 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0047054 name: berbamunine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.19.66, MetaCyc:1.1.3.34-RXN] synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.19.66] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.19.66] xref: EC:1.14.19.66 xref: MetaCyc:1.1.3.34-RXN xref: RHEA:23576 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0047055 name: salutaridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-reticuline + H(+) + NADPH + O(2) = 2 H(2)O + NADP(+) + salutaridine." [EC:1.14.19.67, RHEA:17713] synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.19.67] synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.19.67] xref: EC:1.14.19.67 xref: KEGG_REACTION:R04696 xref: MetaCyc:1.1.3.35-RXN xref: RHEA:17713 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0047056 name: (S)-canadine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + H(+) + NADPH + O(2) = (S)-canadine + 2 H(2)O + NADP(+)." [EC:1.14.19.68, RHEA:21456] synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.19.68] synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.19.68] synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.19.68] xref: EC:1.14.19.68 xref: KEGG_REACTION:R04400 xref: MetaCyc:1.1.3.36-RXN xref: RHEA:21456 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0047057 name: vitamin-K-epoxide reductase (warfarin-sensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN] synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1] synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1] synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1] xref: EC:1.1.4.1 xref: MetaCyc:1.1.4.1-RXN xref: Reactome:R-HSA-159790 "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)" xref: Reactome:R-HSA-6806647 "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)" xref: RHEA:13817 is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: GO:0047058 name: vitamin-K-epoxide reductase (warfarin-insensitive) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN] synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2] synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2] xref: EC:1.1.4.2 xref: MetaCyc:1.1.4.2-RXN xref: RHEA:21560 is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor [Term] id: GO:0047059 name: polyvinyl alcohol dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+." [EC:1.1.2.6] synonym: "polyvinyl alcohol:ferricytochrome-c oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.6] synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" BROAD [EC:1.1.99.23] synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" BROAD [EC:1.1.99.23] synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.99.23] xref: EC:1.1.2.6 xref: KEGG_REACTION:R03136 xref: MetaCyc:RXN-11316 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0047060 name: (R)-pantolactone dehydrogenase (flavin) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)." [EC:1.1.99.27, RHEA:21004] synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27] synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27] synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27] xref: EC:1.1.99.27 xref: KEGG_REACTION:R03156 xref: MetaCyc:1.1.99.27-RXN xref: RHEA:21004 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047061 name: glucose-fructose oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20637] synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28] xref: EC:1.1.99.28 xref: KEGG_REACTION:R00874 xref: MetaCyc:1.1.99.28-RXN xref: RHEA:20637 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047062 name: trans-acenaphthene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH." [EC:1.10.1.1, RHEA:22184] synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1] synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1] xref: EC:1.10.1.1 xref: KEGG_REACTION:R04059 xref: MetaCyc:1.10.1.1-RXN xref: RHEA:22184 is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor [Term] id: GO:0047063 name: L-ascorbate-cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, RHEA:18677] synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1] synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1] xref: EC:1.10.2.1 xref: MetaCyc:1.10.2.1-RXN is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0047064 name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.4, RHEA:24092] synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4] xref: EC:1.21.3.4 xref: KEGG_REACTION:R00060 xref: MetaCyc:1.10.3.7-RXN xref: RHEA:24092 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0047065 name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.5, RHEA:22616] synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5] synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5] xref: EC:1.21.3.5 xref: KEGG_REACTION:R00061 xref: MetaCyc:1.10.3.8-RXN xref: RHEA:22616 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0047066 name: phospholipid-hydroperoxide glutathione peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12] synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12] synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12] synonym: "PHGPX" RELATED [EC:1.11.1.12] synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] xref: EC:1.11.1.12 xref: MetaCyc:1.11.1.12-RXN xref: Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE" xref: Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE" xref: Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA" xref: Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA" is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0047067 name: hydrogen:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone." [EC:1.12.5.1, RHEA:18641] synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1] synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1] synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1] xref: EC:1.12.5.1 xref: KEGG_REACTION:R02965 xref: MetaCyc:1.12.5.1-RXN xref: RHEA:18641 is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor [Term] id: GO:0047068 name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity namespace: molecular_function alt_id: GO:0016947 def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+)." [EC:1.12.98.2, RHEA:20017] synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2] xref: EC:1.12.98.2 xref: KEGG_REACTION:R04455 xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN xref: RHEA:20017 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0047069 name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)." [EC:1.13.11.10, RHEA:23400] synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10] synonym: "7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10] xref: EC:1.13.11.10 xref: KEGG_REACTION:R03253 xref: MetaCyc:1.13.11.10-RXN xref: RHEA:23400 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047070 name: 3-carboxyethylcatechol 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0008669 def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN] synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16] synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16] synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16] xref: EC:1.13.11.16 xref: MetaCyc:1.13.11.16-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047071 name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)." [EC:1.13.11.25, RHEA:21352] synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25] synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25] synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25] xref: EC:1.13.11.25 xref: KEGG_REACTION:R04597 xref: MetaCyc:1.13.11.25-RXN xref: RHEA:21352 xref: UM-BBD_reactionID:r1151 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047072 name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+)." [EC:1.13.11.28, RHEA:15369] synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28] synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28] xref: EC:1.13.11.28 xref: KEGG_REACTION:R01506 xref: MetaCyc:1.13.11.28-RXN xref: RHEA:15369 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047073 name: 2,4'-dihydroxyacetophenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+)." [EC:1.13.11.41, RHEA:24416] synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41] synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41] xref: EC:1.13.11.41 xref: KEGG_REACTION:R01305 xref: MetaCyc:1.13.11.41-RXN xref: RHEA:24416 xref: UM-BBD_reactionID:r1410 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047074 name: 4-hydroxycatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN] xref: EC:1.13.11 xref: MetaCyc:RXN-10137 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047075 name: 2,5-dihydroxypyridine 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN] synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9] synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9] synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9] xref: EC:1.13.11.9 xref: MetaCyc:1.13.11.9-RXN xref: RHEA:27522 xref: UM-BBD_reactionID:r1443 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047077 name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7] synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7] synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7] synonym: "luciferase activity" BROAD [EC:1.13.12.7] synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7] synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7] synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7] xref: EC:1.13.12.7 xref: MetaCyc:1.13.12.7-RXN xref: RHEA:10732 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047078 name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN] synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] xref: EC:1.13.11.47 xref: MetaCyc:1.13.11.47-RXN xref: RHEA:17949 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047079 name: deoxyuridine 1'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil." [EC:1.14.11.10, RHEA:23316] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10] synonym: "pyrimidine-deoxynucleoside 1'-dioxygenase activity" BROAD [EC:1.14.11.10] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" BROAD [EC:1.14.11.10] xref: EC:1.14.11.10 xref: KEGG_REACTION:R02486 xref: MetaCyc:1.14.11.10-RXN xref: RHEA:23316 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0047080 name: deoxyuridine 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine." [EC:1.14.11.3, RHEA:21076] synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3] synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3] synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" BROAD [EC:1.14.11.3] synonym: "pyrimidine-deoxynucleoside 2'-dioxygenase activity" BROAD [EC:1.14.11.3] synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" BROAD [EC:1.14.11.3] synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3] synonym: "thymidine 2'-hydroxylase activity" RELATED [EC:1.14.11.3] synonym: "thymidine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.3] synonym: "thymidine dioxygenase activity" RELATED [EC:1.14.11.3] xref: EC:1.14.11.3 xref: KEGG_REACTION:R01879 xref: MetaCyc:1.14.11.3-RXN xref: RHEA:21076 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0047081 name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate." [EC:1.14.13.242, MetaCyc:1.14.12.4-RXN] synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.13.242] synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.13.242] synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.13.242] synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.13.242] synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.13.242] xref: EC:1.14.13.242 xref: MetaCyc:1.14.12.4-RXN xref: RHEA:10864 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0047082 name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.14.93, RHEA:15321] synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.14.93] synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT [] synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.14.93] xref: EC:1.14.14.93 xref: KEGG_REACTION:R03452 xref: MetaCyc:RXN-4505 xref: RHEA:15321 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047083 name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.14.96, MetaCyc:1.14.13.36-RXN] synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT [] synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.14.96] synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.96] xref: EC:1.14.14.96 xref: MetaCyc:1.14.13.36-RXN xref: RHEA:16265 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047084 name: methyltetrahydroprotoberberine 14-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.14.97, MetaCyc:1.14.13.37-RXN] synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.14.97] synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.14.97] synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.14.97] synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT [] xref: EC:1.14.14.97 xref: MetaCyc:1.14.13.37-RXN xref: RHEA:23684 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047085 name: hydroxyphenylacetonitrile 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+)." [RHEA:23740] synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT [] synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [] xref: KEGG_REACTION:R02708 xref: MetaCyc:1.14.13.42-RXN xref: RHEA:23740 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047086 name: ketosteroid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54] synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54] synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54] xref: EC:1.14.13.54 xref: MetaCyc:1.14.13.54-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047087 name: protopine 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+)." [EC:1.14.14.98, RHEA:22644] synonym: "protopine 6-hydroxylase activity" EXACT [] synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.14.98] xref: EC:1.14.14.98 xref: KEGG_REACTION:R04699 xref: MetaCyc:1.14.13.55-RXN xref: RHEA:22644 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047088 name: dihydrosanguinarine 10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+)." [EC:1.14.14.100, RHEA:10528] synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT [] synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.14.100] xref: EC:1.14.14.100 xref: KEGG_REACTION:R04702 xref: MetaCyc:1.14.13.56-RXN xref: RHEA:10528 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047089 name: dihydrochelirubine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+)." [EC:1.14.14.101, RHEA:10156] synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT [] synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.14.101] xref: EC:1.14.14.101 xref: KEGG_REACTION:R04708 xref: MetaCyc:1.14.13.57-RXN xref: RHEA:10156 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047090 name: benzoyl-CoA 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+)." [EC:1.14.13.58, RHEA:23216] synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT [] synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58] xref: EC:1.14.13.58 xref: KEGG_REACTION:R02449 xref: MetaCyc:1.14.13.58-RXN xref: RHEA:23216 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047091 name: L-lysine 6-monooxygenase (NADPH) activity namespace: molecular_function alt_id: GO:0008739 def: "Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+)." [EC:1.14.13.59, RHEA:23228] comment: Note that EC:1.13.12.10 was merged into this term. synonym: "L-lysine 6-monooxygenase activity" EXACT [] synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59] synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59] synonym: "lysine N6-hydroxylase activity" EXACT [] xref: EC:1.14.13.59 xref: KEGG_REACTION:R00448 xref: MetaCyc:1.14.13.59-RXN xref: RHEA:23228 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047092 name: 27-hydroxycholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.14.29, MetaCyc:1.14.13.60-RXN] synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.14.29] synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.14.29] synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.14.29] synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [] xref: EC:1.14.14.29 xref: MetaCyc:1.14.13.60-RXN xref: RHEA:19041 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047093 name: 4-hydroxyquinoline 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol." [EC:1.14.13.62, RHEA:19325] synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62] synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62] xref: EC:1.14.13.62 xref: KEGG_REACTION:R05154 xref: MetaCyc:1.14.13.62-RXN xref: RHEA:19325 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047094 name: 3-hydroxyphenylacetate 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN] synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63] synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63] xref: EC:1.14.13.63 xref: MetaCyc:1.14.13.63-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047095 name: 2-hydroxycyclohexanone 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+)." [EC:1.14.13.66, RHEA:25172] synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66] xref: EC:1.14.13.66 xref: KEGG_REACTION:R03281 xref: MetaCyc:1.14.13.66-RXN xref: RHEA:25172 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047096 name: androst-4-ene-3,17-dione monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone." [EC:1.14.99.12, RHEA:22696] synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT [] synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12] synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12] synonym: "androstene-3,17-dione hydroxylase activity" EXACT [] synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12] xref: EC:1.14.99.12 xref: KEGG_REACTION:R01833 xref: MetaCyc:1.14.99.12-RXN xref: RHEA:22696 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047097 name: phylloquinone monooxygenase (2,3-epoxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O." [EC:1.14.99.20, RHEA:16745] synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20] synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20] synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20] synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20] xref: EC:1.14.99.20 xref: KEGG_REACTION:R03510 xref: MetaCyc:1.14.99.20-RXN xref: RHEA:16745 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047098 name: Latia-luciferin monooxygenase (demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN] synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21] synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21] synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21] xref: EC:1.14.99.21 xref: MetaCyc:1.14.99.21-RXN xref: RHEA:12677 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047099 name: CDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN] synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1] synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1] synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1] synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1] xref: EC:1.17.1.1 xref: MetaCyc:1.17.1.1-RXN is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0047100 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN] synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13] synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13] xref: EC:1.2.1.13 xref: MetaCyc:1.2.1.13-RXN xref: RHEA:10296 is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity [Term] id: GO:0047101 name: 2-oxoisovalerate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN] synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25] synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25] xref: EC:1.2.1.25 xref: MetaCyc:1.2.1.25-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047102 name: aminomuconate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN] synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] xref: EC:1.2.1.32 xref: MetaCyc:1.2.1.32-RXN xref: Reactome:R-HSA-71239 "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+" xref: RHEA:14469 xref: UM-BBD_reactionID:r1434 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047103 name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [MetaCyc:1.2.1.40-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [] synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [] synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] synonym: "THAL-NAD oxidoreductase activity" EXACT [] synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [] xref: MetaCyc:1.2.1.40-RXN xref: RHEA:24584 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047104 name: hexadecanal dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA." [EC:1.2.1.42, RHEA:19705] synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42] synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42] xref: EC:1.2.1.42 xref: KEGG_REACTION:R01277 xref: MetaCyc:1.2.1.42-RXN xref: RHEA:19705 xref: UM-BBD_reactionID:r1374 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047105 name: 4-trimethylammoniobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN] synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47] xref: EC:1.2.1.47 xref: MetaCyc:1.2.1.47-RXN xref: RHEA:17985 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047106 name: 4-hydroxyphenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN] synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53] synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53] xref: EC:1.2.1.53 xref: MetaCyc:1.2.1.53-RXN xref: RHEA:17273 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0047107 name: gamma-guanidinobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH." [EC:1.2.1.54, RHEA:14381] synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54] synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54] xref: EC:1.2.1.54 xref: KEGG_REACTION:R03177 xref: MetaCyc:1.2.1.54-RXN xref: RHEA:14381 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0047108 name: (R)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.279, RHEA:24352] comment: Note that this term was EC:1.2.1.55. synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279] synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279] xref: EC:1.1.1.279 xref: KEGG_REACTION:R04105 xref: MetaCyc:1.2.1.55-RXN xref: RHEA:24352 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047109 name: (S)-3-hydroxyacid-ester dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.280, RHEA:18269] comment: Note that this term was EC:1.2.1.56. synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT [] synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280] synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280] xref: EC:1.1.1.280 xref: KEGG_REACTION:R04106 xref: MetaCyc:1.2.1.56-RXN xref: RHEA:18269 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047110 name: phenylglyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH." [EC:1.2.1.58, RHEA:10372] synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58] xref: EC:1.2.1.58 xref: KEGG_REACTION:R02450 xref: MetaCyc:1.2.1.58-RXN xref: RHEA:10372 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047111 name: formate dehydrogenase (cytochrome-c-553) activity namespace: molecular_function def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.17.2.3, MetaCyc:1.2.2.3-RXN] synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.17.2.3] synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.17.2.3] xref: EC:1.17.2.3 xref: MetaCyc:1.2.2.3-RXN xref: RHEA:15189 is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0047112 name: pyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2)." [EC:1.2.3.3, RHEA:20848] synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3] synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3] synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3] xref: EC:1.2.3.3 xref: KEGG_REACTION:R00207 xref: MetaCyc:1.2.3.3-RXN xref: RHEA:20848 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0047113 name: aldehyde dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol." [EC:1.2.5.2, MetaCyc:1.2.99.3-RXN] synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3] synonym: "aldehyde dehydrogenase (pyrroloquinoline-quinone)" RELATED [] synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3] xref: EC:1.2.5.2 xref: MetaCyc:1.2.99.3-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047114 name: kynurenate-7,8-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH." [EC:1.3.1.18, RHEA:22248] synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18] synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18] xref: EC:1.3.1.18 xref: KEGG_REACTION:R03251 xref: MetaCyc:1.3.1.18-RXN xref: RHEA:22248 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047115 name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20] synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20] xref: EC:1.3.1.20 xref: MetaCyc:1.3.1.20-RXN xref: RHEA:16729 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047116 name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN] synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25] synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25] synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25] synonym: "DHBDH activity" EXACT [EC:1.3.1.25] synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] xref: EC:1.3.1.25 xref: MetaCyc:1.3.1.25-RXN xref: RHEA:11560 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047117 name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN] synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT [] synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39] xref: EC:1.3.1.39 xref: MetaCyc:1.3.1.39-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047118 name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH." [EC:1.3.1.40, RHEA:24268] synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40] synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40] xref: EC:1.3.1.40 xref: KEGG_REACTION:R03463 xref: MetaCyc:1.3.1.40-RXN xref: RHEA:24268 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047119 name: 2-methyl-branched-chain-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH." [EC:1.3.1.52, RHEA:24532] synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52] xref: EC:1.3.1.52 xref: KEGG_REACTION:R03169 xref: MetaCyc:1.3.1.52-RXN xref: RHEA:24532 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047120 name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity namespace: molecular_function alt_id: GO:0018514 def: "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH." [EC:1.3.1.53, RHEA:10744] synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.53] synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT [] xref: EC:1.3.1.53 xref: KEGG_REACTION:R01633 xref: MetaCyc:1.3.1.53-RXN xref: RHEA:10744 xref: UM-BBD_reactionID:r0151 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047121 name: isoquinoline 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one." [EC:1.3.99.16, RHEA:11588] synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16] xref: EC:1.3.99.16 xref: KEGG_REACTION:R05151 xref: MetaCyc:1.3.99.16-RXN xref: RHEA:11588 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047122 name: quinaldate 4-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate." [EC:1.3.99.18, RHEA:16697] synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18] synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18] xref: EC:1.3.99.18 xref: KEGG_REACTION:R03687 xref: MetaCyc:1.3.99.18-RXN xref: RHEA:16697 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047123 name: quinoline-4-carboxylate 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)." [EC:1.3.99.19, RHEA:14949] synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19] synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19] xref: EC:1.3.99.19 xref: KEGG_REACTION:R05183 xref: MetaCyc:1.3.99.19-RXN xref: RHEA:14949 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047124 name: L-erythro-3,5-diaminohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+)." [EC:1.4.1.11, RHEA:19633] synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11] synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11] xref: EC:1.4.1.11 xref: KEGG_REACTION:R03349 xref: MetaCyc:1.4.1.11-RXN xref: RHEA:19633 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047125 name: delta1-piperideine-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate." [EC:1.5.1.21] synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21] synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21] synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT [] synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21] synonym: "P2C reductase activity" EXACT [EC:1.5.1.21] xref: EC:1.5.1.21 xref: MetaCyc:RXN-8166 xref: RHEA:12524 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047126 name: N5-(carboxyethyl)ornithine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate." [EC:1.5.1.24, RHEA:18661] synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] xref: EC:1.5.1.24 xref: KEGG_REACTION:R00666 xref: MetaCyc:1.5.1.24-RXN xref: RHEA:18661 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047127 name: thiomorpholine-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN] synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25] synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25] synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25] xref: EC:1.5.1.25 xref: MetaCyc:1.5.1.25-RXN xref: Reactome:R-HSA-5693347 "CRYM reduces P2C to PPCA" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047128 name: 1,2-dehydroreticulinium reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH." [EC:1.5.1.27, RHEA:17569] synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27] synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27] xref: EC:1.5.1.27 xref: KEGG_REACTION:R04695 xref: MetaCyc:1.5.1.27-RXN xref: RHEA:17569 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047129 name: opine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate." [EC:1.5.1.28, RHEA:21592] synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] xref: EC:1.5.1.28 xref: KEGG_REACTION:R03732 xref: MetaCyc:1.5.1.28-RXN xref: RHEA:21592 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047130 name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity namespace: molecular_function alt_id: GO:0010010 def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH." [EC:1.5.1.8, RHEA:19373] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8] synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8] xref: EC:1.5.1.8 xref: KEGG_REACTION:R00716 xref: MetaCyc:1.5.1.8-RXN xref: Reactome:R-HSA-70938 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O" xref: RHEA:19373 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0047131 name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH." [EC:1.5.1.9, RHEA:24520] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9] synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9] xref: EC:1.5.1.9 xref: KEGG_REACTION:R02313 xref: MetaCyc:1.5.1.9-RXN xref: Reactome:R-HSA-70940 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+" xref: RHEA:24520 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0047132 name: dihydrobenzophenanthridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN] synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12] xref: EC:1.5.3.12 xref: MetaCyc:1.5.3.12-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0047133 name: dimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN] synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1] synonym: "DMADh activity" RELATED [EC:1.5.8.1] xref: EC:1.5.8.1 xref: MetaCyc:1.5.8.1-RXN xref: UM-BBD_reactionID:r1380 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0047134 name: protein-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN] synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8] synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT [] synonym: "protein-disulphide reductase activity" EXACT [] synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8] xref: EC:1.8.1.8 xref: MetaCyc:1.6.4.4-RXN is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0047135 name: bis-gamma-glutamylcystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH." [EC:1.8.1.13, RHEA:11980] synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT [] synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13] synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13] synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] xref: EC:1.8.1.13 xref: KEGG_REACTION:R02742 xref: MetaCyc:1.6.4.9-RXN xref: RHEA:11980 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0047136 name: 4-(dimethylamino)phenylazoxybenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH." [EC:1.7.1.11, RHEA:19789] synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] xref: EC:1.7.1.11 xref: KEGG_REACTION:R04303 xref: MetaCyc:1.6.6.12-RXN xref: RHEA:19789 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0047137 name: N-hydroxy-2-acetamidofluorene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN] synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] xref: EC:1.7.1.12 xref: MetaCyc:1.7.1.12-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0047138 name: aquacobalamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN] synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "B12a reductase activity" EXACT [EC:1.16.1.3] synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3] synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3] synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3] xref: EC:1.16.1.3 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN xref: RHEA:24472 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0047139 name: glutathione-homocystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN] synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1] xref: EC:1.8.4.1 xref: MetaCyc:1.8.4.1-RXN xref: RHEA:11464 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047140 name: glutathione-CoA-glutathione transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN] synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3] synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3] synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] xref: EC:1.8.4.3 xref: MetaCyc:1.8.4.3-RXN xref: RHEA:13125 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047141 name: glutathione-cystine transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN] synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4] synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] xref: EC:1.8.4.4 xref: MetaCyc:1.8.4.4-RXN xref: RHEA:12613 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047142 name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity namespace: molecular_function def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN] synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT [] synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT [] synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7] synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] xref: EC:1.8.4.7 xref: MetaCyc:1.8.4.7-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0047143 name: chlorate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+)." [EC:1.97.1.1, RHEA:16349] synonym: "chlorate reductase C" RELATED [EC:1.97.1.1] synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1] xref: EC:1.97.1.1 xref: KEGG_REACTION:R03575 xref: MetaCyc:1.97.1.1-RXN xref: RHEA:16349 xref: UM-BBD_reactionID:r0981 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0047144 name: 2-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, GOC:ab, MetaCyc:2-ACYL2.3.1.15-RXN, RHEA:14233] synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52] synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52] xref: EC:2.3.1.52 xref: MetaCyc:2-ACYL2.3.1.15-RXN xref: Reactome:R-HSA-1482533 "2-acyl LPC is acylated to PC by LPCAT" xref: Reactome:R-HSA-1482546 "2-acyl LPG is acylated to PG by CRLS1 (IM)" xref: Reactome:R-HSA-1482626 "2-acyl LPI is acylated to PI by MBOAT7" xref: Reactome:R-HSA-1482635 "2-acyl LPG is acylated to PG by LPGAT" xref: Reactome:R-HSA-1482646 "2-acyl LPE is acylated to PE by LPEAT" xref: Reactome:R-HSA-1482691 "2-acyl LPS is acylated to PS by LPSAT" is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity [Term] id: GO:0047145 name: demethylsterigmatocystin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN] synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109] synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109] synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109] xref: EC:2.1.1.109 xref: MetaCyc:2.1.1.109-RXN xref: RHEA:11504 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047146 name: sterigmatocystin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN] synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110] xref: EC:2.1.1.110 xref: MetaCyc:2.1.1.110-RXN xref: RHEA:15561 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047147 name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)." [EC:2.1.1.19, RHEA:13693] synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19] synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT [] xref: EC:2.1.1.19 xref: KEGG_REACTION:R02573 xref: MetaCyc:2.1.1.19-RXN xref: RHEA:13693 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0047148 name: methylamine-glutamate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+)." [EC:2.1.1.21, RHEA:15837] synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21] synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21] xref: EC:2.1.1.21 xref: KEGG_REACTION:R01586 xref: MetaCyc:2.1.1.21-RXN xref: RHEA:15837 is_a: GO:0008170 ! N-methyltransferase activity [Term] id: GO:0047149 name: thetin-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+)." [EC:2.1.1.3, RHEA:22788] synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3] synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3] xref: EC:2.1.1.3 xref: KEGG_REACTION:R04153 xref: MetaCyc:2.1.1.3-RXN xref: RHEA:22788 is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0047150 name: betaine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336] synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5] synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5] synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5] xref: EC:2.1.1.5 xref: KEGG_REACTION:R02821 xref: MetaCyc:2.1.1.5-RXN xref: Reactome:R-HSA-1614654 "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY" xref: RHEA:22336 is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0047151 name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN] synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74] synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74] synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT [] xref: EC:2.1.1.74 xref: KEGG_REACTION:R03704 xref: MetaCyc:2.1.1.74-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0047152 name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity namespace: molecular_function alt_id: GO:1990087 def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN] comment: This function is the first step in the pathway of methanogenesis from methanol. synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol-corrinoid protein Co-methyltransferase." EXACT [] synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90] synonym: "methanol:corrinoid methyltransferase activity" EXACT [] synonym: "methyltransferase 1" BROAD [] synonym: "MT 1" RELATED [EC:2.1.1.90] synonym: "MT1" RELATED [] synonym: "MtaB" RELATED [] xref: EC:2.1.1.90 xref: MetaCyc:2.1.1.90-RXN xref: RHEA:21344 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0047153 name: deoxycytidylate 5-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, RHEA:11280] synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8] synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8] synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT [] synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8] xref: EC:2.1.2.8 xref: KEGG_REACTION:R01669 xref: MetaCyc:2.1.2.8-RXN xref: RHEA:11280 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0047154 name: methylmalonyl-CoA carboxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1] synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT [] synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1] synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1] xref: EC:2.1.3.1 xref: MetaCyc:2.1.3.1-RXN xref: RHEA:20764 xref: UM-BBD_reactionID:r0923 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0047155 name: 3-hydroxymethylcephem carbamoyltransferase activity namespace: molecular_function alt_id: GO:0045447 def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN] synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT [] synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7] xref: EC:2.1.3.7 xref: MetaCyc:2.1.3.7-RXN is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0047156 name: acetoin-ribose-5-phosphate transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, RHEA:21504] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4] synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] xref: EC:2.2.1.4 xref: KEGG_REACTION:R02345 xref: MetaCyc:2.2.1.4-RXN xref: RHEA:21504 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0047157 name: myelin-proteolipid O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN] synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100] synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100] synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] xref: EC:2.3.1.100 xref: MetaCyc:2.3.1.100-RXN is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0047158 name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose." [EC:2.3.1.103, RHEA:22664] synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103] synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] xref: EC:2.3.1.103 xref: KEGG_REACTION:R00063 xref: MetaCyc:2.3.1.103-RXN xref: RHEA:22664 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0047159 name: 1-alkenylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.25] xref: EC:2.3.1.25 xref: MetaCyc:2.3.1.104-RXN xref: RHEA:10344 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047160 name: alkylglycerophosphate 2-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, RHEA:18557] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105] synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105] xref: EC:2.3.1.105 xref: KEGG_REACTION:R03455 xref: MetaCyc:2.3.1.105-RXN xref: RHEA:18557 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047161 name: tartronate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate." [EC:2.3.1.106, RHEA:10952] synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106] synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106] synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106] xref: EC:2.3.1.106 xref: KEGG_REACTION:R03965 xref: MetaCyc:2.3.1.106-RXN xref: RHEA:10952 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047162 name: 17-O-deacetylvindoline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA." [EC:2.3.1.107, RHEA:24496] synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "DAT activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107] synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] xref: EC:2.3.1.107 xref: KEGG_REACTION:R03230 xref: MetaCyc:2.3.1.107-RXN xref: RHEA:24496 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047163 name: 3,4-dichloroaniline N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA." [EC:2.3.1.114, RHEA:21060] synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114] xref: EC:2.3.1.114 xref: KEGG_REACTION:R04050 xref: MetaCyc:2.3.1.114-RXN xref: RHEA:21060 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047164 name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN] synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115] synonym: "MAT-7" RELATED [EC:2.3.1.115] xref: EC:2.3.1.115 xref: MetaCyc:2.3.1.115-RXN xref: RHEA:15581 is_a: GO:0050736 ! O-malonyltransferase activity [Term] id: GO:0047165 name: flavonol-3-O-beta-glucoside O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN] synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] synonym: "MAT-3" RELATED [EC:2.3.1.116] xref: EC:2.3.1.116 xref: MetaCyc:2.3.1.116-RXN xref: RHEA:20085 is_a: GO:0050736 ! O-malonyltransferase activity [Term] id: GO:0047166 name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN] synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121] xref: EC:2.3.1.121 xref: MetaCyc:2.3.1.121-RXN xref: RHEA:16245 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047167 name: 1-alkyl-2-acetylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN] synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125] synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125] xref: EC:2.3.1.125 xref: MetaCyc:2.3.1.125-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047168 name: isocitrate O-dihydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, RHEA:20756] synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126] xref: EC:2.3.1.126 xref: KEGG_REACTION:R01946 xref: MetaCyc:2.3.1.126-RXN xref: RHEA:20756 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047169 name: galactarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA." [EC:2.3.1.130, RHEA:12997] synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130] synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130] xref: EC:2.3.1.130 xref: KEGG_REACTION:R03727 xref: MetaCyc:2.3.1.130-RXN xref: RHEA:12997 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047170 name: glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA." [EC:2.3.1.131, RHEA:23308] synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131] xref: EC:2.3.1.131 xref: KEGG_REACTION:R02899 xref: MetaCyc:2.3.1.131-RXN xref: RHEA:23308 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047171 name: glucarolactone O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN] synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132] xref: EC:2.3.1.132 xref: MetaCyc:2.3.1.132-RXN xref: RHEA:14261 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047172 name: shikimate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN] synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133] synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133] xref: EC:2.3.1.133 xref: MetaCyc:2.3.1.133-RXN xref: RHEA:12124 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047173 name: phosphatidylcholine-retinol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN] synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135] synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135] xref: EC:2.3.1.135 xref: MetaCyc:2.3.1.135-RXN xref: Reactome:R-HSA-975608 "LRAT esterifies RBP2:atROL and FACYLs to atREs" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047174 name: putrescine N-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+)." [EC:2.3.1.138, RHEA:12436] synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138] synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] synonym: "PHT" RELATED [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138] synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] xref: EC:2.3.1.138 xref: KEGG_REACTION:R01944 xref: MetaCyc:2.3.1.138-RXN xref: RHEA:12436 is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0050734 ! hydroxycinnamoyltransferase activity [Term] id: GO:0047175 name: galactosylacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN] synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141] synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141] xref: EC:2.3.1.141 xref: MetaCyc:2.3.1.141-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047176 name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.143, RHEA:19109] synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] xref: EC:2.3.1.143 xref: KEGG_REACTION:R04498 xref: MetaCyc:2.3.1.143-RXN xref: RHEA:19109 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047177 name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN] synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] xref: EC:2.3.1.147 xref: MetaCyc:2.3.1.147-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047178 name: glycerophospholipid acyltransferase (CoA-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN] synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148] xref: EC:2.3.1.148 xref: MetaCyc:2.3.1.148-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047179 name: platelet-activating factor acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN] synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149] synonym: "PAF acetyltransferase activity" EXACT [] xref: EC:2.3.1.149 xref: MetaCyc:2.3.1.149-RXN is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0047180 name: salutaridinol 7-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, RHEA:22856] synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150] xref: EC:2.3.1.150 xref: KEGG_REACTION:R04723 xref: MetaCyc:2.3.1.150-RXN xref: RHEA:22856 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047181 name: tetrahydroxybenzophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN] synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151] xref: EC:2.3.1.151 xref: MetaCyc:2.3.1.151-RXN xref: RHEA:19305 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047182 name: alcohol O-cinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN] synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152] xref: EC:2.3.1.152 xref: MetaCyc:2.3.1.152-RXN xref: RHEA:23524 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047183 name: anthocyanin 5-aromatic acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN] synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153] xref: EC:2.3.1.153 xref: MetaCyc:RXN-7945 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047184 name: 1-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function alt_id: GO:0000507 def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23] synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23] synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] xref: EC:2.3.1.23 xref: MetaCyc:2.3.1.23-RXN xref: Reactome:R-HSA-1482794 "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)" xref: RHEA:12937 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047185 name: N-acetylneuraminate 4-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, RHEA:18305] synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44] xref: EC:2.3.1.44 xref: KEGG_REACTION:R01806 xref: MetaCyc:2.3.1.44-RXN xref: RHEA:18305 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047186 name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN] synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45] synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] xref: EC:2.3.1.45 xref: MetaCyc:2.3.1.45-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047187 name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN] synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49] xref: EC:2.3.1.49 xref: MetaCyc:2.3.1.49-RXN is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0047188 name: aromatic-hydroxylamine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN] synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56] synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56] xref: EC:2.3.1.56 xref: MetaCyc:2.3.1.56-RXN xref: RHEA:20325 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047189 name: 2,3-diaminopropionate N-oxalyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA." [EC:2.3.1.58, RHEA:13465] synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58] synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58] xref: EC:2.3.1.58 xref: KEGG_REACTION:R04211 xref: MetaCyc:2.3.1.58-RXN xref: RHEA:13465 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047190 name: 2-acylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.62, RHEA:10332] synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62] synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62] xref: EC:2.3.1.62 xref: KEGG_REACTION:R01319 xref: MetaCyc:2.3.1.62-RXN xref: RHEA:10332 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047191 name: 1-alkylglycerophosphocholine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63] xref: EC:2.3.1.63 xref: MetaCyc:2.3.1.63-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047192 name: 1-alkylglycerophosphocholine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN] synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67] synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67] synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] xref: EC:2.3.1.67 xref: MetaCyc:2.3.1.67-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047193 name: obsolete CDP-acylglycerol O-arachidonoyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN] comment: This term was made obsolete because the evidence for the existence of this reaction was retracted. Please see PMID:6885763 for more information. synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70] synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] synonym: "CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [] synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT [] synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] xref: MetaCyc:2.3.1.70-RXN is_obsolete: true [Term] id: GO:0047194 name: indoleacetylglucose-inositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose." [EC:2.3.1.72, RHEA:21180] synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72] synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72] xref: EC:2.3.1.72 xref: KEGG_REACTION:R04333 xref: MetaCyc:2.3.1.72-RXN xref: RHEA:21180 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047195 name: diacylglycerol-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN] synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73] synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73] xref: EC:2.3.1.73 xref: MetaCyc:2.3.1.73-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047196 name: long-chain-alcohol O-fatty-acyltransferase activity namespace: molecular_function alt_id: GO:0103095 def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN] synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75] synonym: "wax ester synthase activity" EXACT [] synonym: "wax synthase activity" RELATED [EC:2.3.1.75] synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75] xref: EC:2.3.1.75 xref: MetaCyc:2.3.1.75-RXN xref: MetaCyc:RXNQT-4193 xref: Reactome:R-HSA-5696424 "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters" xref: Reactome:R-HSA-8848582 "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester" xref: RHEA:38443 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047197 name: triglyceride-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN] synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT [] synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77] synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77] xref: EC:2.3.1.77 xref: MetaCyc:2.3.1.77-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047198 name: cysteine-S-conjugate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+)." [EC:2.3.1.80, RHEA:19213] synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80] xref: EC:2.3.1.80 xref: KEGG_REACTION:R04950 xref: MetaCyc:2.3.1.80-RXN xref: Reactome:R-HSA-5433066 "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C" xref: RHEA:19213 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047199 name: phosphatidylcholine-dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol." [EC:2.3.1.83, RHEA:19285] synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83] xref: EC:2.3.1.83 xref: KEGG_REACTION:R04227 xref: MetaCyc:2.3.1.83-RXN xref: RHEA:19285 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047200 name: tetrahydrodipicolinate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13085] synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89] synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89] xref: EC:2.3.1.89 xref: KEGG_REACTION:R04364 xref: MetaCyc:2.3.1.89-RXN xref: RHEA:13085 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047201 name: beta-glucogallin O-galloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.90, RHEA:11416] synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90] xref: EC:2.3.1.90 xref: KEGG_REACTION:R00049 xref: MetaCyc:2.3.1.90-RXN xref: RHEA:11416 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047202 name: sinapoylglucose-choline O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose." [EC:2.3.1.91, RHEA:12024] synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91] synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91] xref: EC:2.3.1.91 xref: KEGG_REACTION:R03075 xref: MetaCyc:2.3.1.91-RXN xref: RHEA:12024 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0047203 name: 13-hydroxylupinine O-tigloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA." [EC:2.3.1.93, RHEA:12360] synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93] synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93] synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93] xref: EC:2.3.1.93 xref: KEGG_REACTION:R04205 xref: MetaCyc:2.3.1.93-RXN xref: RHEA:12360 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047204 name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate." [EC:2.3.1.98, RHEA:23204] synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98] synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98] xref: EC:2.3.1.98 xref: KEGG_REACTION:R02998 xref: MetaCyc:2.3.1.98-RXN xref: RHEA:23204 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047205 name: quinate O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN] synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99] synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99] xref: EC:2.3.1.99 xref: MetaCyc:2.3.1.99-RXN xref: RHEA:15021 is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity [Term] id: GO:0047206 name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN] synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] xref: EC:2.3.2.10 xref: MetaCyc:2.3.2.10-RXN xref: RHEA:12432 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047207 name: 1,2-beta-fructan 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN] synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100] synonym: "FFT activity" EXACT [EC:2.4.1.100] synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100] xref: EC:2.4.1.100 xref: MetaCyc:2.4.1.100-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0047208 name: o-dihydroxycoumarin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP." [EC:2.4.1.104, RHEA:14325] synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104] xref: EC:2.4.1.104 xref: KEGG_REACTION:R03548 xref: MetaCyc:2.4.1.104-RXN xref: RHEA:14325 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047209 name: coniferyl-alcohol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN] synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] xref: EC:2.4.1.111 xref: MetaCyc:2.4.1.111-RXN xref: RHEA:23944 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047211 name: alpha-1,4-glucan-protein synthase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN] synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT [] synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113] xref: EC:2.4.1.113 xref: MetaCyc:2.4.1.113-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0047212 name: 2-coumarate O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP." [EC:2.4.1.114, RHEA:10236] synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114] xref: EC:2.4.1.114 xref: KEGG_REACTION:R03710 xref: MetaCyc:2.4.1.114-RXN xref: RHEA:10236 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047213 name: anthocyanidin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN] synonym: "3-GT activity" EXACT [EC:2.4.1.115] synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] xref: EC:2.4.1.115 xref: MetaCyc:2.4.1.115-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047214 name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN] synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] xref: EC:2.4.1.116 xref: MetaCyc:2.4.1.116-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047215 name: indole-3-acetate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP." [EC:2.4.1.121, RHEA:14921] synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121] synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121] synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121] synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:auxin glucosyltransferase activity" BROAD [] synonym: "UDP-glucose:indol-3-acetic acid glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121] synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121] synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] xref: EC:2.4.1.121 xref: KEGG_REACTION:R03094 xref: MetaCyc:2.4.1.121-RXN xref: RHEA:14921 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047216 name: inositol 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN] synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123] synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] xref: EC:2.4.1.123 xref: MetaCyc:2.4.1.123-RXN xref: RHEA:12464 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047217 name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN] synonym: "GTF-S" RELATED [EC:2.4.1.125] synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125] synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125] xref: EC:2.4.1.125 xref: MetaCyc:2.4.1.125-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0047218 name: hydroxycinnamate 4-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN] synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] xref: EC:2.4.1.126 xref: MetaCyc:2.4.1.126-RXN xref: RHEA:21636 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047219 name: monoterpenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.127, RHEA:11520] synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] xref: EC:2.4.1.127 xref: KEGG_REACTION:R02179 xref: MetaCyc:2.4.1.127-RXN xref: RHEA:11520 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047220 name: galactosylxylosylprotein 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134] synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134] xref: EC:2.4.1.134 xref: MetaCyc:2.4.1.134-RXN xref: Reactome:R-HSA-1889978 "B3GALT6 transfers Gal to the tetrasaccharide linker" xref: Reactome:R-HSA-4420365 "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker" is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047221 name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.137, RHEA:14285] synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137] synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137] synonym: "FPS" RELATED [EC:2.4.1.137] synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137] synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] xref: EC:2.4.1.137 xref: KEGG_REACTION:R00853 xref: MetaCyc:2.4.1.137-RXN xref: RHEA:14285 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047222 name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN] synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138] synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] xref: EC:2.4.1.138 xref: MetaCyc:2.4.1.138-RXN xref: RHEA:13705 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047223 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN] synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146] xref: EC:2.4.1.146 xref: MetaCyc:2.4.1.146-RXN xref: Reactome:R-HSA-5617037 "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" xref: Reactome:R-HSA-5617096 "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" xref: RHEA:12227 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047224 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN] synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147] xref: EC:2.4.1.147 xref: MetaCyc:2.4.1.147-RXN xref: RHEA:14252 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047225 name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN] synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148] synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148] synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148] synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148] synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148] xref: EC:2.4.1.148 xref: MetaCyc:2.4.1.148-RXN xref: RHEA:16552 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047227 name: indolylacetyl-myo-inositol galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP." [EC:2.4.1.156, RHEA:21148] synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156] xref: EC:2.4.1.156 xref: KEGG_REACTION:R04334 xref: MetaCyc:2.4.1.156-RXN xref: RHEA:21148 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047228 name: 1,2-diacylglycerol 3-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN] synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] xref: EC:2.4.1.157 xref: MetaCyc:2.4.1.157-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047229 name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN] synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] xref: EC:2.4.1.158 xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN xref: RHEA:22316 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047230 name: flavonol-3-O-glucoside L-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN] synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] xref: EC:2.4.1.159 xref: MetaCyc:2.4.1.159-RXN xref: RHEA:22528 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047231 name: pyridoxine 5'-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP." [EC:2.4.1.160, RHEA:20177] synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] xref: EC:2.4.1.160 xref: KEGG_REACTION:R01912 xref: MetaCyc:2.4.1.160-RXN xref: RHEA:20177 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047232 name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164] xref: EC:2.4.1.164 xref: MetaCyc:2.4.1.164-RXN xref: RHEA:18028 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047233 name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN] synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] xref: EC:2.4.1.165 xref: MetaCyc:2.4.1.165-RXN xref: RHEA:13569 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047234 name: raffinose-raffinose alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN] synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT [] synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166] synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166] xref: EC:2.4.1.166 xref: MetaCyc:2.4.1.166-RXN xref: RHEA:14125 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047235 name: sucrose 6F-alpha-galactotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN] synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT [] synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] xref: EC:2.4.1.167 xref: MetaCyc:2.4.1.167-RXN xref: RHEA:10088 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047236 name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN] synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171] synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] xref: EC:2.4.1.171 xref: MetaCyc:2.4.1.171-RXN xref: RHEA:20205 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047237 name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN] synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase I activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174] synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174] xref: EC:2.4.1.174 xref: MetaCyc:2.4.1.174-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047238 name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "N-acetylgalactosaminyltransferase II activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175] xref: EC:2.4.1.175 xref: MetaCyc:2.4.1.175-RXN xref: Reactome:R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin" xref: Reactome:R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin" xref: Reactome:R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin" xref: Reactome:R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin" is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047239 name: hydroxymandelonitrile glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP." [EC:2.4.1.178, RHEA:15961] synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] xref: EC:2.4.1.178 xref: KEGG_REACTION:R02709 xref: MetaCyc:2.4.1.178-RXN xref: RHEA:15961 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047240 name: lactosylceramide beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP." [EC:2.4.1.179, RHEA:18413] synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179] xref: EC:2.4.1.179 xref: KEGG_REACTION:R04431 xref: MetaCyc:2.4.1.179-RXN xref: RHEA:18413 is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0047241 name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN] synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT [] synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180] synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180] synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180] xref: EC:2.4.1.180 xref: MetaCyc:2.4.1.180-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047242 name: hydroxyanthraquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN] synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181] xref: EC:2.4.1.181 xref: MetaCyc:2.4.1.181-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047243 name: flavanone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN] synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185] synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] xref: EC:2.4.1.185 xref: MetaCyc:2.4.1.185-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047244 name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN] synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] xref: EC:2.4.1.187 xref: MetaCyc:TEICHOICSYN2-RXN xref: RHEA:16053 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047245 name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN] synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] xref: EC:2.4.1.188 xref: MetaCyc:2.4.1.188-RXN xref: RHEA:20952 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047246 name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP." [EC:2.4.1.190, RHEA:14149] synonym: "LMT activity" RELATED [EC:2.4.1.190] synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190] xref: EC:2.4.1.190 xref: KEGG_REACTION:R06827 xref: MetaCyc:2.4.1.190-RXN xref: RHEA:14149 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047247 name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.191, RHEA:22116] synonym: "LDT" RELATED [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191] synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191] xref: EC:2.4.1.191 xref: KEGG_REACTION:R06828 xref: MetaCyc:2.4.1.191-RXN xref: RHEA:22116 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047248 name: nuatigenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP." [EC:2.4.1.192, RHEA:19329] synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192] xref: EC:2.4.1.192 xref: KEGG_REACTION:R04577 xref: MetaCyc:2.4.1.192-RXN xref: RHEA:19329 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047249 name: sarsapogenin 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.193, RHEA:14461] synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193] xref: EC:2.4.1.193 xref: KEGG_REACTION:R04359 xref: MetaCyc:2.4.1.193-RXN xref: RHEA:14461 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047250 name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP." [EC:2.4.1.194, RHEA:15153] synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] xref: EC:2.4.1.194 xref: KEGG_REACTION:R01304 xref: MetaCyc:2.4.1.194-RXN xref: RHEA:15153 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047251 name: thiohydroximate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN] synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] xref: EC:2.4.1.195 xref: MetaCyc:2.4.1.195-RXN xref: RHEA:13757 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047252 name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN] synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199] synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199] xref: EC:2.4.1.199 xref: MetaCyc:2.4.1.199-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047253 name: alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN] synonym: "alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT [] synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] xref: EC:2.4.1.201 xref: MetaCyc:2.4.1.201-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047254 name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN] synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202] xref: EC:2.4.1.202 xref: MetaCyc:2.4.1.202-RXN xref: RHEA:15541 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047255 name: galactogen 6-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN] synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "beta-(1,6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205] xref: EC:2.4.1.205 xref: MetaCyc:2.4.1.205-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047256 name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN] synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206] synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] xref: EC:2.4.1.206 xref: MetaCyc:2.4.1.206-RXN xref: RHEA:13905 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047257 name: diglucosyl diacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN] synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208] synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT [] synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] xref: EC:2.4.1.208 xref: MetaCyc:2.4.1.208-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047258 name: sphingosine beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP." [EC:2.4.1.23, RHEA:19485] synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23] synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23] synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23] xref: EC:2.4.1.23 xref: KEGG_REACTION:R01928 xref: MetaCyc:2.4.1.23-RXN xref: RHEA:19485 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047259 name: glucomannan 4-beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN] synonym: "GDP-man-beta-mannan mannosyltransferase activity" EXACT [EC:2.4.1.32] synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT [] synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT [] synonym: "glucomannan-synthase activity" EXACT [] xref: EC:2.4.1.32 xref: MetaCyc:2.4.1.32-RXN is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0047260 name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN] synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36] xref: EC:2.4.1.36 xref: MetaCyc:2.4.1.36-RXN xref: RHEA:14605 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047261 name: steroid N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP." [EC:2.4.1.39, RHEA:14153] synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] xref: EC:2.4.1.39 xref: KEGG_REACTION:R04451 xref: MetaCyc:2.4.1.39-RXN xref: RHEA:14153 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047262 name: polygalacturonate 4-alpha-galacturonosyltransferase activity namespace: molecular_function alt_id: GO:0050375 def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN] synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] xref: EC:2.4.1.43 xref: MetaCyc:2.4.1.43-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047263 name: N-acylsphingosine galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN] synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] xref: EC:2.4.1.47 xref: MetaCyc:2.4.1.47-RXN xref: Reactome:R-HSA-6785933 "UGT8 transfers Gal from UDP-Gal to CERA" xref: RHEA:13093 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047264 name: heteroglycan alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48] synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "heteropolysaccharide alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.48 is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047265 name: poly(glycerol-phosphate) alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN] synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] xref: EC:2.4.1.52 xref: MetaCyc:2.4.1.52-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047266 name: poly(ribitol-phosphate) beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN] synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] xref: EC:2.4.1.53 xref: MetaCyc:2.4.1.53-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047267 name: undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol." [EC:2.4.1.54] synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54] synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54] synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] xref: EC:2.4.1.54 is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0047268 name: galactinol-raffinose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN] synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67] synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67] xref: EC:2.4.1.67 xref: MetaCyc:2.4.1.67-RXN xref: RHEA:20776 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047269 name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN] synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70] synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] xref: EC:2.4.1.70 xref: MetaCyc:2.4.1.70-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0047270 name: lipopolysaccharide glucosyltransferase II activity namespace: molecular_function def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, GOC:mr, GOC:pr, MetaCyc:2.4.1.73-RXN] synonym: "LPS glucosyltransferase II activity" EXACT [] synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73] xref: EC:2.4.1.73 xref: MetaCyc:2.4.1.73-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0047271 name: glycosaminoglycan galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN] synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74] xref: EC:2.4.1.74 xref: MetaCyc:2.4.1.74-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047272 name: phosphopolyprenol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN] synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] xref: EC:2.4.1.78 xref: MetaCyc:2.4.1.78-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047273 name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity namespace: molecular_function alt_id: GO:0047226 def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN] synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79] synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79] synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79] synonym: "globoside synthase activity" EXACT [EC:2.4.1.79] synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79] synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] xref: EC:2.4.1.79 xref: MetaCyc:2.4.1.79-RXN xref: Reactome:R-HSA-8878914 "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer" xref: RHEA:22252 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047274 name: galactinol-sucrose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN] synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT [] synonym: "galactosyltransferase, galactinol-sucrose" EXACT [] synonym: "raffinose synthase activity" EXACT [] xref: EC:2.4.1.82 xref: MetaCyc:2.4.1.82-RXN xref: RHEA:20161 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0047275 name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN] synonym: "GalT-4" RELATED [EC:2.4.1.86] synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86] synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86] xref: EC:2.4.1.86 xref: MetaCyc:2.4.1.86-RXN xref: RHEA:16045 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047276 name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity namespace: molecular_function alt_id: GO:0003946 def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN] synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87] synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] xref: EC:2.4.1.87 xref: MetaCyc:2.4.1.151-RXN xref: RHEA:13013 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047277 name: globoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN] synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88] synonym: "forssman synthase activity" EXACT [EC:2.4.1.88] synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88] synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] xref: EC:2.4.1.88 xref: MetaCyc:2.4.1.88-RXN xref: RHEA:22164 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0047278 name: bilirubin-glucuronoside glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside." [RHEA:16885] synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [] synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [] synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [] xref: KEGG_REACTION:R00062 xref: MetaCyc:2.4.1.95-RXN xref: RHEA:16885 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0047279 name: sn-glycerol-3-phosphate 1-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.96, RHEA:20341] synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96] synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96] synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96] xref: EC:2.4.1.96 xref: KEGG_REACTION:R00854 xref: MetaCyc:2.4.1.96-RXN xref: RHEA:20341 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047280 name: nicotinamide phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [EC:2.4.2.12, RHEA:16149] synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12] synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12] xref: EC:2.4.2.12 xref: KEGG_REACTION:R01271 xref: MetaCyc:2.4.2.12-RXN xref: Reactome:R-HSA-197250 "NAMPT transfers PRIB to NAM to form NAMN" xref: RHEA:16149 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047281 name: dioxotetrahydropyrimidine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN] synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20] synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] xref: EC:2.4.2.20 xref: MetaCyc:2.4.2.20-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047282 name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)." [EC:2.4.2.27, RHEA:24392] synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] xref: EC:2.4.2.27 xref: KEGG_REACTION:R04222 xref: MetaCyc:2.4.2.27-RXN xref: RHEA:24392 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047283 name: dolichyl-phosphate D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN] synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32] xref: EC:2.4.2.32 xref: MetaCyc:2.4.2.32-RXN xref: RHEA:15361 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0047284 name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN] synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33] xref: EC:2.4.2.33 xref: MetaCyc:2.4.2.33-RXN is_a: GO:0042285 ! xylosyltransferase activity [Term] id: GO:0047285 name: flavonol-3-O-glycoside xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN] synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35] xref: EC:2.4.2.35 xref: MetaCyc:2.4.2.35-RXN xref: RHEA:19701 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0047286 name: NAD+-diphthamide ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36] synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36] synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.36 xref: MetaCyc:RXN-11372 xref: Reactome:R-HSA-5336421 "DT fragment A ADP-ribosylates target cell EEF" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047287 name: lactosylceramide alpha-2,6-N-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11] xref: EC:2.4.99.11 xref: MetaCyc:2.4.99.11-RXN xref: RHEA:21552 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047288 name: monosialoganglioside sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN] synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2] xref: EC:2.4.99.2 xref: MetaCyc:2.4.99.2-RXN xref: RHEA:18021 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047289 name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)." [EC:2.4.99.5, RHEA:11664] synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5] xref: EC:2.4.99.5 xref: KEGG_REACTION:R03468 xref: MetaCyc:2.4.99.5-RXN xref: RHEA:11664 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047290 name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, RHEA:10479] synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7] synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7] synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7] synonym: "SIAT7" RELATED [EC:2.4.99.7] synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7] xref: EC:2.4.99.7 xref: KEGG_REACTION:R04635 xref: MetaCyc:2.4.99.7-RXN xref: Reactome:R-HSA-981809 "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen" xref: RHEA:10479 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047291 name: lactosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN] synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9] synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9] synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9] synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9] synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9] synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9] synonym: "SAT 1" RELATED [EC:2.4.99.9] xref: EC:2.4.99.9 xref: MetaCyc:2.4.99.9-RXN xref: RHEA:18417 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0047292 name: trihydroxypterocarpan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36] xref: EC:2.5.1.36 xref: MetaCyc:2.5.1.36-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047293 name: 4-hydroxybenzoate nonaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN] synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39] xref: EC:2.5.1.39 xref: MetaCyc:2.5.1.39-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0047294 name: phosphoglycerol geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.41, RHEA:23404] synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41] synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] xref: EC:2.5.1.41 xref: KEGG_REACTION:R04158 xref: MetaCyc:2.5.1.41-RXN xref: RHEA:23404 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047295 name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, RHEA:18109] synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42] xref: EC:2.5.1.42 xref: KEGG_REACTION:R04520 xref: MetaCyc:2.5.1.42-RXN xref: RHEA:18109 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047296 name: homospermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN] synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44] xref: EC:2.5.1.44 xref: MetaCyc:2.5.1.44-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047297 name: asparagine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN] synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14] synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] xref: EC:2.6.1.14 xref: MetaCyc:2.6.1.14-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047298 name: (S)-3-amino-2-methylpropionate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate." [EC:2.6.1.22, RHEA:13993] synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT [] synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22] synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22] synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22] synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22] xref: EC:2.6.1.22 xref: KEGG_REACTION:R04188 xref: MetaCyc:2.6.1.22-RXN xref: RHEA:13993 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047299 name: tryptophan-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine." [EC:2.6.1.28, RHEA:13741] synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.28 xref: KEGG_REACTION:R01376 xref: MetaCyc:2.6.1.28-RXN xref: RHEA:13741 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047300 name: pyridoxamine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal." [EC:2.6.1.30, RHEA:12841] synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT [] synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30] synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30] xref: EC:2.6.1.30 xref: KEGG_REACTION:R01712 xref: MetaCyc:2.6.1.30-RXN xref: RHEA:12841 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047301 name: valine-3-methyl-2-oxovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine." [EC:2.6.1.32, RHEA:11468] synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32] synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32] synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT [] xref: EC:2.6.1.32 xref: KEGG_REACTION:R02200 xref: MetaCyc:2.6.1.32-RXN xref: RHEA:11468 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047302 name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose." [EC:2.6.1.34, RHEA:18713] synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [] synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT [] synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34] xref: EC:2.6.1.34 xref: KEGG_REACTION:R04529 xref: MetaCyc:2.6.1.34-RXN xref: RHEA:18713 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047303 name: glycine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate." [EC:2.6.1.35, RHEA:17141] synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35] synonym: "glycine-oxaloacetate aminotransferase activity" EXACT [] synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] xref: EC:2.6.1.35 xref: KEGG_REACTION:R00373 xref: MetaCyc:2.6.1.35-RXN xref: RHEA:17141 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047304 name: 2-aminoethylphosphonate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17021] synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.37 xref: KEGG_REACTION:R04152 xref: MetaCyc:2.6.1.37-RXN xref: RHEA:17021 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047305 name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0047314 def: "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine." [EC:2.6.1.40, RHEA:18393] comment: Note that this function was EC:2.6.1.61. synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT [] synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT [] synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40] synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40] synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] xref: EC:2.6.1.40 xref: KEGG_REACTION:R02050 xref: MetaCyc:2.6.1.40-RXN xref: Reactome:R-HSA-909780 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine" xref: RHEA:18393 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047306 name: D-methionine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine." [EC:2.6.1.41, RHEA:23836] synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] synonym: "D-methionine-pyruvate aminotransferase activity" EXACT [] synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] xref: EC:2.6.1.41 xref: KEGG_REACTION:R03001 xref: MetaCyc:2.6.1.41-RXN xref: RHEA:23836 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047307 name: diaminobutyrate-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde." [EC:2.6.1.46, RHEA:12380] synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT [] synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46] xref: EC:2.6.1.46 xref: KEGG_REACTION:R02293 xref: MetaCyc:2.6.1.46-RXN xref: RHEA:12380 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047308 name: alanine-oxomalonate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate." [EC:2.6.1.47, RHEA:18809] synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47] synonym: "alanine-oxomalonate aminotransferase activity" EXACT [] synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47] synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] xref: EC:2.6.1.47 xref: KEGG_REACTION:R02970 xref: MetaCyc:2.6.1.47-RXN xref: RHEA:18809 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047309 name: dihydroxyphenylalanine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.49, RHEA:15273] synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49] synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT [] synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49] synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49] synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49] synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49] xref: EC:2.6.1.49 xref: KEGG_REACTION:R02077 xref: MetaCyc:2.6.1.49-RXN xref: RHEA:15273 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047310 name: glutamine-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate." [EC:2.6.1.50, RHEA:22920] synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT [] synonym: "glutamine-scyllo-inosose transaminase activity" EXACT [] synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50] xref: EC:2.6.1.50 xref: KEGG_REACTION:R02781 xref: MetaCyc:2.6.1.50-RXN xref: RHEA:22920 is_a: GO:0070548 ! L-glutamine aminotransferase activity [Term] id: GO:0047311 name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine." [EC:2.6.1.56, RHEA:15497] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT [] synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56] xref: EC:2.6.1.56 xref: KEGG_REACTION:R03502 xref: MetaCyc:2.6.1.56-RXN xref: RHEA:15497 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047312 name: L-phenylalanine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN] synonym: "histidine aminotransferase activity" RELATED [GOC:kad] synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad] synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad] synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad] synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58] synonym: "phenylalanine(histidine) aminotransferase activity" BROAD [] synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58] synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] xref: EC:2.6.1.58 xref: KEGG_REACTION:R00692 xref: MetaCyc:2.6.1.58-RXN xref: Reactome:R-HSA-893593 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine" is_a: GO:0070546 ! L-phenylalanine aminotransferase activity [Term] id: GO:0047313 name: aromatic-amino-acid-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN] synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] xref: EC:2.6.1.60 xref: MetaCyc:2.6.1.60-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047315 name: kynurenine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine." [EC:2.6.1.63, RHEA:19249] synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63] synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT [] synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63] xref: EC:2.6.1.63 xref: KEGG_REACTION:R01957 xref: MetaCyc:2.6.1.63-RXN xref: RHEA:19249 is_a: GO:0036137 ! kynurenine aminotransferase activity [Term] id: GO:0047316 name: glutamine-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17593] synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64] synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] xref: EC:2.6.1.64 xref: KEGG_REACTION:R01375 xref: MetaCyc:2.6.1.64-RXN xref: RHEA:17593 is_a: GO:0070548 ! L-glutamine aminotransferase activity [Term] id: GO:0047317 name: N6-acetyl-beta-lysine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN] synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT [] xref: EC:2.6.1.65 xref: MetaCyc:2.6.1.65-RXN xref: RHEA:16889 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047319 name: aspartate-phenylpyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate." [EC:2.6.1.70, RHEA:14097] synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT [] synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] xref: EC:2.6.1.70 xref: KEGG_REACTION:R00695 xref: MetaCyc:2.6.1.70-RXN xref: RHEA:14097 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047320 name: D-4-hydroxyphenylglycine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate." [EC:2.6.1.72, RHEA:15589] synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT [] synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72] synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72] xref: EC:2.6.1.72 xref: KEGG_REACTION:R04234 xref: MetaCyc:2.6.1.72-RXN xref: RHEA:15589 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047321 name: diphosphate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN] synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1] synonym: "DiPPT" RELATED [EC:2.7.99.1] synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1] xref: EC:2.7.99.1 xref: MetaCyc:2.7.99.1-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047322 name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN] synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "AMPK" RELATED [EC:2.7.11.31] synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31] synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31] synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] synonym: "STK29" RELATED [EC:2.7.11.31] xref: EC:2.7.11.31 xref: MetaCyc:2.7.1.109-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047323 name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4] synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4] synonym: "BCK" RELATED [EC:2.7.11.4] synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4] synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4] synonym: "STK2" RELATED [EC:2.7.11.4] xref: EC:2.7.11.4 xref: MetaCyc:2.7.11.4-RXN xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047324 name: phosphoenolpyruvate-glycerone phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate." [EC:2.7.1.121, RHEA:18381] synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121] xref: EC:2.7.1.121 xref: KEGG_REACTION:R01012 xref: MetaCyc:2.7.1.121-RXN xref: RHEA:18381 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047325 name: inositol tetrakisphosphate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134] synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 1-kinase activity" BROAD [] synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] xref: EC:2.7.1.134 xref: MetaCyc:2.7.1.134-RXN xref: Reactome:R-HSA-1855162 "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol" xref: Reactome:R-HSA-994137 "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5" xref: RHEA:12452 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0047326 name: inositol tetrakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140] synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT [] xref: EC:2.7.1.140 xref: MetaCyc:2.7.1.140-RXN xref: Reactome:R-HSA-1855228 "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" xref: RHEA:12717 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0047327 name: glycerol-3-phosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol." [EC:2.7.1.142, RHEA:21288] synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142] xref: EC:2.7.1.142 xref: KEGG_REACTION:R00850 xref: MetaCyc:2.7.1.142-RXN xref: RHEA:21288 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047328 name: acyl-phosphate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN] synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61] synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61] xref: EC:2.7.1.61 xref: MetaCyc:2.7.1.61-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047329 name: phosphoramidate-hexose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN] synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62] synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] xref: EC:2.7.1.62 xref: MetaCyc:2.7.1.62-RXN xref: RHEA:10972 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047330 name: polyphosphate-glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN] synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] xref: EC:2.7.1.63 xref: MetaCyc:2.7.1.63-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047331 name: diphosphate-glycerol phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate." [EC:2.7.1.79, RHEA:13689] synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] xref: EC:2.7.1.79 xref: KEGG_REACTION:R01044 xref: MetaCyc:2.7.1.79-RXN xref: RHEA:13689 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047332 name: diphosphate-serine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate." [EC:2.7.1.80, RHEA:23764] synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80] synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80] xref: EC:2.7.1.80 xref: KEGG_REACTION:R00584 xref: MetaCyc:2.7.1.80-RXN xref: RHEA:23764 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047333 name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+)." [EC:2.7.1.88, RHEA:16281] synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88] synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88] xref: EC:2.7.1.88 xref: KEGG_REACTION:R03395 xref: MetaCyc:2.7.1.88-RXN xref: RHEA:16281 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0047334 name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90] synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90] synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90] synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90] xref: EC:2.7.1.90 xref: MetaCyc:2.7.1.90-RXN xref: RHEA:13613 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0047335 name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN] synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] xref: EC:2.7.4.17 xref: MetaCyc:2.7.4.17-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047336 name: 5-methyldeoxycytidine-5'-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+)." [EC:2.7.4.19, RHEA:11396] synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19] xref: EC:2.7.4.19 xref: KEGG_REACTION:R04235 xref: MetaCyc:2.7.4.19-RXN xref: RHEA:11396 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047337 name: dolichyl-diphosphate-polyphosphate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN] synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] xref: EC:2.7.4.20 xref: MetaCyc:2.7.4.20-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047338 name: UTP:xylose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN] synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11] synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] xref: EC:2.7.7.11 xref: MetaCyc:2.7.7.11-RXN xref: RHEA:18389 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0047339 name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity namespace: molecular_function alt_id: GO:0047340 def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN] synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28] synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28] synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW [] synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "NDP-hexose diphosphorylase activity" EXACT [] synonym: "NDP-hexose pyrophosphorylase activity" EXACT [] synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] xref: EC:2.7.7.28 xref: MetaCyc:2.7.7.28-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047341 name: fucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose." [EC:2.7.7.30, RHEA:13549] synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] xref: EC:2.7.7.30 xref: KEGG_REACTION:R01951 xref: MetaCyc:2.7.7.30-RXN xref: Reactome:R-HSA-6787533 "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc" xref: RHEA:13549 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047342 name: galactose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose." [EC:2.7.7.32, RHEA:17165] synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32] synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] xref: EC:2.7.7.32 xref: KEGG_REACTION:R02329 xref: MetaCyc:2.7.7.32-RXN xref: RHEA:17165 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047343 name: glucose-1-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, RHEA:18213] synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] xref: EC:2.7.7.33 xref: KEGG_REACTION:R00956 xref: MetaCyc:2.7.7.33-RXN xref: RHEA:18213 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047344 name: glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose." [EC:2.7.7.34, RHEA:10708] synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34] synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] xref: EC:2.7.7.34 xref: KEGG_REACTION:R00954 xref: MetaCyc:2.7.7.34-RXN xref: RHEA:10708 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047345 name: ribose-5-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate." [EC:2.7.7.35, RHEA:14529] synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35] synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35] synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.35 xref: KEGG_REACTION:R01052 xref: MetaCyc:2.7.7.35-RXN xref: RHEA:14529 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047346 name: aldose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN] synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36] synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT [] synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36] synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36] xref: EC:2.7.7.36 xref: MetaCyc:2.7.7.36-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047347 name: aldose-1-phosphate nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN] synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37] synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37] synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37] xref: EC:2.7.7.37 xref: MetaCyc:2.7.7.37-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0047348 name: glycerol-3-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate." [EC:2.7.7.39, RHEA:13361] synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] synonym: "Gro-PCT" RELATED [EC:2.7.7.39] xref: EC:2.7.7.39 xref: KEGG_REACTION:R00856 xref: MetaCyc:2.7.7.39-RXN xref: RHEA:13361 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047349 name: D-ribitol-5-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, RHEA:12456] synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT [] synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40] xref: EC:2.7.7.40 xref: KEGG_REACTION:R02921 xref: MetaCyc:2.7.7.40-RXN xref: RHEA:12456 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047350 name: glucuronate-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate." [EC:2.7.7.44, RHEA:16325] synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44] synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44] synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT [] xref: EC:2.7.7.44 xref: KEGG_REACTION:R01381 xref: MetaCyc:2.7.7.44-RXN xref: RHEA:16325 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0047351 name: guanosine-triphosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+)." [EC:2.7.7.45, RHEA:18153] synonym: "GTP:GTP guanylyltransferase activity" BROAD [] xref: EC:2.7.7.45 xref: KEGG_REACTION:R00012 xref: MetaCyc:2.7.7.45-RXN xref: RHEA:18153 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0047352 name: adenylylsulfate-ammonia adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate." [EC:2.7.7.51, RHEA:19197] synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51] synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT [] synonym: "APSAT" RELATED [EC:2.7.7.51] xref: EC:2.7.7.51 xref: KEGG_REACTION:R01619 xref: MetaCyc:2.7.7.51-RXN xref: RHEA:19197 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047353 name: N-methylphosphoethanolamine cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate." [EC:2.7.7.57, RHEA:10576] synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57] synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] xref: EC:2.7.7.57 xref: KEGG_REACTION:R03375 xref: MetaCyc:2.7.7.57-RXN xref: RHEA:10576 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0047354 name: sphingosine cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine." [EC:2.7.8.10, RHEA:21224] synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10] synonym: "sphingosine choline phosphotransferase activity" EXACT [] xref: EC:2.7.8.10 xref: KEGG_REACTION:R01929 xref: MetaCyc:2.7.8.10-RXN xref: RHEA:21224 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047355 name: CDP-glycerol glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN] synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "CGPTase activity" EXACT [EC:2.7.8.12] synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12] synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12] synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] xref: EC:2.7.8.12 xref: MetaCyc:2.7.8.12-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047356 name: CDP-ribitol ribitolphosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN] synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14] synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14] synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] xref: EC:2.7.8.14 xref: MetaCyc:2.7.8.14-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047357 name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, RHEA:22440] synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] xref: EC:2.7.8.18 xref: KEGG_REACTION:R00504 xref: MetaCyc:2.7.8.18-RXN xref: RHEA:22440 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047358 name: UDP-glucose-glycoprotein glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN] synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "GlcPTase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] xref: EC:2.7.8.19 xref: MetaCyc:2.7.8.19-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047359 name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN] synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22] synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22] xref: EC:2.7.8.22 xref: MetaCyc:2.7.8.22-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047360 name: undecaprenyl-phosphate galactose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, RHEA:11652] synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6] synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6] xref: EC:2.7.8.6 xref: KEGG_REACTION:R01535 xref: MetaCyc:2.7.8.6-RXN xref: RHEA:11652 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047361 name: phosphomannan mannosephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN] synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9] xref: EC:2.7.8.9 xref: MetaCyc:2.7.8.9-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047362 name: thiosulfate-dithiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN] synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5] synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5] synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT [] synonym: "TSR" RELATED [EC:2.8.1.5] xref: EC:2.8.1.5 xref: MetaCyc:2.8.1.5-RXN xref: RHEA:15121 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0047363 name: triglucosylalkylacylglycerol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN] synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19] synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19] xref: EC:2.8.2.19 xref: MetaCyc:2.8.2.19-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047364 name: desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+)." [EC:2.8.2.24, RHEA:20281] synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] synonym: "desulphoglucosinolate sulphotransferase activity" EXACT [] synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] xref: EC:2.8.2.24 xref: KEGG_REACTION:R03214 xref: MetaCyc:2.8.2.24-RXN xref: RHEA:20281 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047365 name: quercetin-3-sulfate 3'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate." [EC:2.8.2.26, RHEA:22504] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.26 xref: KEGG_REACTION:R02632 xref: MetaCyc:2.8.2.26-RXN xref: RHEA:22504 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047366 name: quercetin-3-sulfate 4'-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate." [EC:2.8.2.27, RHEA:17205] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT [] xref: EC:2.8.2.27 xref: KEGG_REACTION:R02633 xref: MetaCyc:2.8.2.27-RXN xref: RHEA:17205 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047367 name: quercetin-3,3'-bissulfate 7-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN] synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT [] xref: EC:2.8.2.28 xref: MetaCyc:2.8.2.28-RXN xref: RHEA:21860 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047368 name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate." [EC:2.8.2.7, RHEA:14337] synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] xref: EC:2.8.2.7 xref: KEGG_REACTION:R04476 xref: MetaCyc:2.8.2.7-RXN xref: RHEA:14337 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047369 name: succinate-hydroxymethylglutarate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN] synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13] synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13] synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13] xref: EC:2.8.3.13 xref: MetaCyc:2.8.3.13-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047370 name: succinate-citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [MetaCyc:2.8.3.7-RXN] synonym: "citramalate coenzyme A-transferase activity" EXACT [] synonym: "itaconate CoA-transferase activity" EXACT [] synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [] synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [] xref: MetaCyc:2.8.3.7-RXN xref: RHEA:23528 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047371 name: butyrate-acetoacetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate." [EC:2.8.3.9, RHEA:12961] synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9] synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] xref: EC:2.8.3.9 xref: KEGG_REACTION:R01365 xref: MetaCyc:2.8.3.9-RXN xref: RHEA:12961 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047372 name: acylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] subset: goslim_chembl synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23] synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23] xref: EC:3.1.1.23 xref: MetaCyc:3.1.1.23-RXN xref: Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL" xref: Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid" xref: Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase" xref: Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase" xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2" xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG" xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL" xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047373 name: acetoxybutynylbithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.54, RHEA:11548] synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54] synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54] synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54] xref: EC:3.1.1.54 xref: KEGG_REACTION:R04490 xref: MetaCyc:3.1.1.54-RXN xref: RHEA:11548 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047374 name: methylumbelliferyl-acetate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+)." [EC:3.1.1.56, RHEA:12208] synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56] synonym: "esterase D activity" RELATED [EC:3.1.1.56] xref: EC:3.1.1.56 xref: KEGG_REACTION:R04141 xref: MetaCyc:3.1.1.56-RXN xref: RHEA:12208 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047375 name: N-acetylgalactosaminoglycan deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN] synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58] synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58] synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] xref: EC:3.1.1.58 xref: MetaCyc:3.1.1.58-RXN is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047376 name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [MetaCyc:3.1.1.64-RXN, RHEA:13933] synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD [EC:3.1.1.64] synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64] synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG_REACTION:R02368] xref: EC:3.1.1 xref: KEGG_REACTION:R02368 xref: MetaCyc:3.1.1.64-RXN xref: Reactome:R-HSA-2404140 "NREH hydrolyses atREs to atROL and FAs" xref: Reactome:R-HSA-2429643 "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs" xref: RHEA:13933 is_a: GO:0052689 ! carboxylic ester hydrolase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0047377 name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.66, RHEA:16313] synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66] synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66] synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66] xref: EC:3.1.1.66 xref: KEGG_REACTION:R04525 xref: MetaCyc:3.1.1.66-RXN xref: RHEA:16313 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047378 name: acetylalkylglycerol acetylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+)." [EC:3.1.1.71, RHEA:11552] synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] xref: EC:3.1.1.71 xref: KEGG_REACTION:R04043 xref: MetaCyc:3.1.1.71-RXN xref: RHEA:11552 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047379 name: ADP-dependent short-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN] synonym: "ADP-dependent propionyl coenzyme A hydrolase activity" NARROW [EC:3.1.2.18] synonym: "ADP-dependent propionyl-CoA hydrolase activity" NARROW [EC:3.1.2.18] synonym: "ADP-dependent propionyl-CoA thioesterase activity" NARROW [EC:3.1.2.18] synonym: "ADP-dependent short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] synonym: "ADP-dependent short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] synonym: "ADP-dependent short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] xref: EC:3.1.2.18 xref: MetaCyc:3.1.2.18-RXN is_a: GO:0047617 ! acyl-CoA hydrolase activity [Term] id: GO:0047380 name: ADP-dependent medium-chain-acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN] synonym: "ADP-dependent medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "ADP-dependent medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] synonym: "ADP-dependent medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "ADP-dependent medium-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "ADP-dependent myristoyl-CoA thioesterase activity" NARROW [EC:3.1.2.19] synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] xref: EC:3.1.2.19 xref: MetaCyc:3.1.2.19-RXN is_a: GO:0052815 ! medium-chain acyl-CoA hydrolase activity [Term] id: GO:0047381 name: dodecanoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function alt_id: GO:0016294 def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN] synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "dodecanoyl-ACP hydrolase activity" EXACT [] synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21] synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "lauroyl-ACP hydrolase activity" EXACT [] synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] xref: EC:3.1.2.21 xref: MetaCyc:3.1.2.21-RXN is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0047382 name: methylphosphothioglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate." [EC:3.1.3.14, RHEA:16081] synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14] synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14] xref: EC:3.1.3.14 xref: KEGG_REACTION:R04317 xref: MetaCyc:3.1.3.14-RXN xref: RHEA:16081 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047383 name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate." [EC:3.1.3.40, RHEA:15777] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40] synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40] xref: EC:3.1.3.40 xref: KEGG_REACTION:R03496 xref: MetaCyc:3.1.3.40-RXN xref: RHEA:15777 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047384 name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47] synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47] synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47] xref: EC:3.1.3.47 xref: MetaCyc:3.1.3.47-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0047385 name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52] synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] xref: EC:3.1.3.52 xref: MetaCyc:3.1.3.52-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0047386 name: fructose-2,6-bisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate." [EC:3.1.3.54, RHEA:13333] synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54] synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] xref: EC:3.1.3.54 xref: KEGG_REACTION:R02730 xref: MetaCyc:3.1.3.54-RXN xref: RHEA:13333 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0047387 name: serine-ethanolaminephosphate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine." [EC:3.1.4.13, RHEA:17113] synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13] synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13] synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13] xref: EC:3.1.4.13 xref: KEGG_REACTION:R02817 xref: MetaCyc:3.1.4.13-RXN xref: RHEA:17113 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047388 name: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase namespace: molecular_function def: "Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]." [MetaCyc:3.1.4.15-RXN] comment: Formerly EC:3.1.4.15. synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [] synonym: "adenylyl-[glutamate-ammonia ligase] hydrolase activity" EXACT [] synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [] synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [] synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [] xref: EC:2.7.7.89 xref: KEGG_REACTION:R03474 xref: MetaCyc:3.1.4.15-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0047389 name: glycerophosphocholine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN] synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2] synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2] xref: EC:3.1.4.2 xref: MetaCyc:3.1.4.2-RXN xref: Reactome:R-HSA-6814132 "GDPD5 hydrolyzes GPCho" xref: RHEA:16061 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047390 name: glycerophosphocholine cholinephosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+)." [EC:3.1.4.38, RHEA:19545] synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] xref: EC:3.1.4.38 xref: KEGG_REACTION:R02591 xref: MetaCyc:3.1.4.38-RXN xref: Reactome:R-HSA-6814797 "ENPP6 hydrolyzes lysophosphatidylcholine" xref: RHEA:19545 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047391 name: alkylglycerophosphoethanolamine phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39] synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] xref: EC:3.1.4.39 xref: MetaCyc:3.1.4.39-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047392 name: CMP-N-acylneuraminate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN] synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40] synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40] xref: EC:3.1.4.40 xref: MetaCyc:3.1.4.40-RXN xref: RHEA:20185 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047393 name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+)." [EC:3.1.4.42, RHEA:16493] synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42] synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42] xref: EC:3.1.4.42 xref: KEGG_REACTION:R02648 xref: MetaCyc:3.1.4.42-RXN xref: RHEA:16493 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047394 name: glycerophosphoinositol inositolphosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN] synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT [] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] xref: EC:3.1.4.43 xref: MetaCyc:3.1.4.43-RXN xref: RHEA:14033 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047395 name: glycerophosphoinositol glycerophosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+)." [EC:3.1.4.44, RHEA:16501] synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] xref: EC:3.1.4.44 xref: KEGG_REACTION:R01193 xref: MetaCyc:3.1.4.44-RXN xref: Reactome:R-HSA-6813740 "GDE1 hydrolyzes GroPIns" xref: RHEA:16501 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047396 name: glycosylphosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14] synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14] synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14] synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14] synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14] synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT [] synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14] xref: EC:4.6.1.14 xref: MetaCyc:3.1.4.47-RXN xref: RHEA:14333 is_a: GO:0016849 ! phosphorus-oxygen lyase activity is_a: GO:0046423 ! allene-oxide cyclase activity [Term] id: GO:0047397 name: dolichylphosphate-glucose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN] synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48] synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT [] xref: EC:3.1.4.48 xref: MetaCyc:3.1.4.48-RXN xref: RHEA:13857 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047398 name: dolichylphosphate-mannose phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN] synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49] synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49] xref: EC:3.1.4.49 xref: MetaCyc:3.1.4.49-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0047399 name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN] synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51] synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51] xref: EC:3.1.4.51 xref: MetaCyc:3.1.4.51-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047400 name: phosphonoacetate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate." [EC:3.11.1.2, RHEA:16749] synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2] xref: EC:3.11.1.2 xref: KEGG_REACTION:R00318 xref: MetaCyc:3.11.1.2-RXN xref: RHEA:16749 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0047401 name: trithionate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate." [EC:3.12.1.1, RHEA:21884] synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1] xref: EC:3.12.1.1 xref: KEGG_REACTION:R01930 xref: MetaCyc:3.12.1.1-RXN xref: RHEA:21884 is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds [Term] id: GO:0047402 name: protein-glucosylgalactosylhydroxylysine glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN] synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107] synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107] xref: EC:3.2.1.107 xref: MetaCyc:3.2.1.107-RXN is_a: GO:0015926 ! glucosidase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0047403 name: lacto-N-biosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] xref: EC:3.2.1.140 xref: RHEA:21568 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047404 name: glucuronosyl-disulfoglucosamine glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN] synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] xref: EC:3.2.1.56 xref: MetaCyc:3.2.1.56-RXN xref: RHEA:15073 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047405 name: pyrimidine-5'-nucleotide nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN] synonym: "Pyr5N activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10] xref: EC:3.2.2.10 xref: MetaCyc:3.2.2.10-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047406 name: beta-aspartyl-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine." [EC:3.2.2.11, RHEA:12324] synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11] synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11] xref: EC:3.2.2.11 xref: KEGG_REACTION:R01266 xref: MetaCyc:3.2.2.11-RXN xref: RHEA:12324 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047407 name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN] synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24] synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24] synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24] synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24] xref: EC:3.2.2.24 xref: MetaCyc:3.2.2.24-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047408 name: alkenylglycerophosphocholine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2] synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2] xref: EC:3.3.2.2 xref: MetaCyc:3.3.2.2-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047409 name: alkenylglycerophosphoethanolamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN] synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5] xref: EC:3.3.2.5 xref: MetaCyc:3.3.2.5-RXN is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047410 name: N-formylmethionylaminoacyl-tRNA deformylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [MetaCyc:3.5.1.27-RXN] synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [] xref: MetaCyc:3.5.1.27-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047411 name: 2-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN] synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29] synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29] xref: EC:3.5.1.29 xref: MetaCyc:3.5.1.29-RXN xref: RHEA:10432 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047412 name: N-(long-chain-acyl)ethanolamine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN] synonym: "acylethanolamine amidase activity" EXACT [] synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] xref: EC:3.5.1.60 xref: MetaCyc:3.5.1.60-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047413 name: N(alpha)-benzyloxycarbonylleucine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2)." [EC:3.5.1.64, RHEA:18901] synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] xref: EC:3.5.1.64 xref: KEGG_REACTION:R02552 xref: MetaCyc:3.5.1.64-RXN xref: RHEA:18901 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047414 name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+)." [EC:3.5.1.66, RHEA:17677] synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66] synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66] synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66] xref: EC:3.5.1.66 xref: KEGG_REACTION:R04397 xref: MetaCyc:3.5.1.66-RXN xref: RHEA:17677 xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating) is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047415 name: D-benzoylarginine-4-nitroanilide amidase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+)." [EC:3.5.1.72, RHEA:14421] synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72] synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72] synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72] xref: EC:3.5.1.72 xref: KEGG_REACTION:R04113 xref: MetaCyc:3.5.1.72-RXN xref: RHEA:14421 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047416 name: arylalkyl acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN] synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76] synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76] xref: EC:3.5.1.76 xref: MetaCyc:3.5.1.76-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047417 name: N-carbamoyl-D-amino acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN] synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77] xref: EC:3.5.1.77 xref: MetaCyc:3.5.1.77-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047418 name: phthalyl amidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN] synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79] xref: EC:3.5.1.79 xref: MetaCyc:3.5.1.79-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047419 name: N-acetylgalactosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN] xref: EC:3.5.1.25 xref: MetaCyc:3.5.1.80-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047420 name: N-acyl-D-amino-acid deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN] synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81] synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81] xref: EC:3.5.1.81 xref: MetaCyc:3.5.1.81-RXN xref: RHEA:18309 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047421 name: N-acyl-D-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate." [EC:3.5.1.82, RHEA:12833] synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82] xref: EC:3.5.1.82 xref: KEGG_REACTION:R01581 xref: MetaCyc:3.5.1.82-RXN xref: RHEA:12833 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047422 name: N-acyl-D-aspartate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate." [EC:3.5.1.83, RHEA:18285] synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83] xref: EC:3.5.1.83 xref: KEGG_REACTION:R02182 xref: MetaCyc:3.5.1.83-RXN xref: RHEA:18285 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047423 name: N-methylhydantoinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate." [EC:3.5.2.14, RHEA:11720] synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14] synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] xref: EC:3.5.2.14 xref: KEGG_REACTION:R03187 xref: MetaCyc:3.5.2.14-RXN xref: RHEA:11720 xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047424 name: methylenediurea deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN] synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21] synonym: "methylenediurease activity" EXACT [EC:3.5.3.21] xref: EC:3.5.3.21 xref: MetaCyc:3.5.3.21-RXN xref: RHEA:24651 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047425 name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+)." [EC:3.5.4.22, RHEA:10560] synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22] synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22] xref: EC:3.5.4.22 xref: KEGG_REACTION:R02280 xref: MetaCyc:3.5.4.22-RXN xref: RHEA:10560 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047426 name: ricinine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN] synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2] xref: EC:3.5.5.2 xref: MetaCyc:3.5.5.2-RXN xref: RHEA:22704 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047427 name: cyanoalanine nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+)." [EC:3.5.5.4, RHEA:25310] synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4] synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4] xref: EC:3.5.5.4 xref: KEGG_REACTION:R00486 xref: MetaCyc:3.5.5.4-RXN xref: RHEA:25310 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047428 name: arylacetonitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN] synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5] xref: EC:3.5.5.5 xref: MetaCyc:3.5.5.5-RXN xref: RHEA:20657 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0047429 name: nucleoside-triphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide." [EC:3.6.1.9, MetaCyc:3.6.1.19-RXN] synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:3.6.1.19-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047430 name: oligosaccharide-diphosphodolichol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN] synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44] synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] xref: EC:3.6.1.44 xref: MetaCyc:3.6.1.44-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047431 name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2)." [EC:4.1.1.51, RHEA:13669] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51] synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51] xref: EC:4.1.1.51 xref: KEGG_REACTION:R03461 xref: MetaCyc:4.1.1.51-RXN xref: RHEA:13669 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047432 name: 2,2-dialkylglycine decarboxylase (pyruvate) activity namespace: molecular_function def: "Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone." [EC:4.1.1.64, RHEA:16073] synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64] synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64] synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64] synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64] synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64] synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64] xref: EC:4.1.1.64 xref: KEGG_REACTION:R03854 xref: MetaCyc:4.1.1.64-RXN xref: RHEA:16073 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047433 name: branched-chain-2-oxoacid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2)." [EC:4.1.1.72, RHEA:21108] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72] synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72] synonym: "BCKA" RELATED [EC:4.1.1.72] synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72] synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72] xref: EC:4.1.1.72 xref: KEGG_REACTION:R03894 xref: MetaCyc:4.1.1.72-RXN xref: RHEA:21108 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047434 name: indolepyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN] synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74] synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74] xref: EC:4.1.1.74 xref: MetaCyc:4.1.1.74-RXN xref: RHEA:18017 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047435 name: 5-guanidino-2-oxopentanoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2)." [EC:4.1.1.75, RHEA:11340] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] xref: EC:4.1.1.75 xref: KEGG_REACTION:R03178 xref: MetaCyc:4.1.1.75-RXN xref: RHEA:11340 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047436 name: arylmalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2)." [EC:4.1.1.76, RHEA:20513] synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76] synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76] synonym: "AMDASE" RELATED [EC:4.1.1.76] synonym: "AMDase activity" EXACT [EC:4.1.1.76] xref: EC:4.1.1.76 xref: KEGG_REACTION:R05173 xref: MetaCyc:4.1.1.76-RXN xref: RHEA:20513 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047437 name: 4-oxalocrotonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN] synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77] synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77] xref: EC:4.1.1.77 xref: MetaCyc:4.1.1.77-RXN xref: RHEA:24260 xref: UM-BBD_reactionID:r1435 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047438 name: 2-dehydro-3-deoxy-L-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18] synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18] synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18] xref: EC:4.1.2.18 xref: MetaCyc:4.1.2.18-RXN xref: RHEA:18545 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047439 name: 3-deoxy-D-manno-octulosonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, RHEA:23340] synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23] synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23] synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23] xref: EC:4.1.2.23 xref: KEGG_REACTION:R01576 xref: MetaCyc:4.1.2.23-RXN xref: RHEA:23340 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047440 name: 2-dehydro-3-deoxy-D-pentonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, RHEA:20609] synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28] synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28] synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28] xref: EC:4.1.2.28 xref: KEGG_REACTION:R01782 xref: MetaCyc:4.1.2.28-RXN xref: RHEA:20609 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047441 name: 5-dehydro-2-deoxyphosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate." [EC:4.1.2.29, RHEA:13177] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29] synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] xref: EC:4.1.2.29 xref: KEGG_REACTION:R05378 xref: MetaCyc:4.1.2.29-RXN xref: RHEA:13177 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047442 name: 17-alpha-hydroxyprogesterone aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN] synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30] synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30] xref: EC:4.1.2.30 xref: MetaCyc:4.1.2.30-RXN xref: RHEA:14753 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047443 name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN] synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17] synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17] synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17] synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17] xref: EC:4.1.3.17 xref: MetaCyc:4.1.3.17-RXN xref: RHEA:22748 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047444 name: N-acylneuraminate-9-phosphate synthase activity namespace: molecular_function alt_id: GO:0019007 def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN] synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah] synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57] synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57] synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] xref: EC:2.5.1.57 xref: MetaCyc:4.1.3.20-RXN xref: Reactome:R-HSA-4084976 "NANS converts ManNAc-6-P to Neu5Ac-9-P" xref: RHEA:13421 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047445 name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate." [EC:4.1.3.26, RHEA:23084] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26] synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26] xref: EC:4.1.3.26 xref: KEGG_REACTION:R08090 xref: MetaCyc:4.1.3.26-RXN xref: RHEA:23084 xref: UM-BBD_reactionID:r1168 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047446 name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone." [EC:4.1.3.35, RHEA:23868] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35] synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35] xref: EC:4.1.3.35 xref: KEGG_REACTION:R02232 xref: MetaCyc:4.1.3.35-RXN xref: RHEA:23868 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047447 name: erythro-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20] synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20] synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT [] synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20] xref: EC:4.3.1.20 xref: MetaCyc:4.3.1.20-RXN xref: RHEA:19757 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047448 name: 5-dehydro-4-deoxyglucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O." [EC:4.2.1.41, RHEA:24608] synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41] synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41] synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41] synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41] synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41] xref: EC:4.2.1.41 xref: KEGG_REACTION:R02279 xref: MetaCyc:4.2.1.41-RXN xref: RHEA:24608 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047449 name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O." [EC:4.2.1.43, RHEA:17201] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43] synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43] synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43] xref: EC:4.2.1.43 xref: KEGG_REACTION:R02278 xref: MetaCyc:4.2.1.43-RXN xref: RHEA:17201 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047450 name: crotonoyl-[acyl-carrier-protein] hydratase activity namespace: molecular_function alt_id: GO:0080063 def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN] synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58] synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58] synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58] synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58] synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [] synonym: "crotonoyl-ACP hydratase activity" EXACT [] synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58] synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58] xref: EC:4.2.1.58 xref: KEGG_REACTION:R04428 xref: MetaCyc:4.2.1.58-RXN is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0047451 name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN] synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59] synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59] synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] xref: EC:4.2.1.59 xref: KEGG_REACTION:R04537 xref: MetaCyc:4.2.1.59-RXN is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0047452 name: protoaphin-aglucone dehydratase (cyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin." [EC:4.2.1.73, RHEA:23876] synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73] synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73] xref: EC:4.2.1.73 xref: KEGG_REACTION:R03742 xref: MetaCyc:4.2.1.73-RXN xref: RHEA:23876 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047453 name: ATP-dependent NAD(P)H-hydrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, RHEA:19017] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93] synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93] xref: EC:4.2.1.93 xref: KEGG_REACTION:R00129 xref: MetaCyc:4.2.1.93-RXN xref: Reactome:R-HSA-6806967 "CARKD dehydrates S-NAD(P)HX to NADPH" xref: RHEA:19017 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047454 name: phaseollidin hydratase activity namespace: molecular_function def: "Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin." [EC:4.2.1.97, RHEA:19769] synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97] synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97] xref: EC:4.2.1.97 xref: KEGG_REACTION:R04728 xref: MetaCyc:4.2.1.97-RXN xref: RHEA:19769 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047455 name: 16-alpha-hydroxyprogesterone dehydratase activity namespace: molecular_function alt_id: GO:0047523 def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN] synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16-dehydroprogesterone hydratase activity" RELATED [] synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98] synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98] synonym: "hydroxyprogesterone dehydroxylase activity" EXACT [] xref: EC:4.2.1.98 xref: MetaCyc:4.2.1.98-RXN xref: RHEA:12584 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047456 name: 2-methylisocitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.99, RHEA:17941] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99] synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99] xref: EC:4.2.1.99 xref: KEGG_REACTION:R04425 xref: MetaCyc:4.2.1.99-RXN xref: RHEA:17941 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047457 name: exo-(1,4)-alpha-D-glucan lyase activity namespace: molecular_function def: "Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN] synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13] synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13] synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13] synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13] synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13] xref: EC:4.2.2.13 xref: MetaCyc:4.2.2.13-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047458 name: beta-pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)." [EC:2.5.1.51, RHEA:13117] synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT [] synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51] synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51] xref: EC:2.5.1.51 xref: KEGG_REACTION:R03134 xref: MetaCyc:2.5.1.51-RXN xref: RHEA:13117 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047459 name: 3-aminobutyryl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+)." [EC:4.3.1.14, RHEA:10056] synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14] synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14] xref: EC:4.3.1.14 xref: KEGG_REACTION:R03030 xref: MetaCyc:4.3.1.14-RXN xref: RHEA:10056 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047460 name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+)." [EC:4.5.1.4, RHEA:11620] synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4] synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4] xref: EC:4.5.1.4 xref: KEGG_REACTION:R02605 xref: MetaCyc:4.5.1.4-RXN xref: RHEA:11620 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0047461 name: (+)-delta-cadinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13] synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13] xref: EC:4.2.3.13 xref: MetaCyc:4.6.1.11-RXN xref: RHEA:19525 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0047462 name: phenylalanine racemase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20201] synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11] synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11] synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11] synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11] xref: EC:5.1.1.11 xref: KEGG_REACTION:R00686 xref: MetaCyc:5.1.1.11-RXN xref: RHEA:20201 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047463 name: 2-aminohexano-6-lactam racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam." [EC:5.1.1.15, RHEA:14813] synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15] synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15] xref: EC:5.1.1.15 xref: KEGG_REACTION:R04736 xref: MetaCyc:5.1.1.15-RXN xref: RHEA:14813 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0047464 name: heparosan-N-sulfate-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17] synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT [] synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17] synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17] xref: EC:5.1.3.17 xref: MetaCyc:5.1.3.17-RXN xref: RHEA:20197 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047465 name: N-acylglucosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] xref: EC:5.1.3.9 xref: MetaCyc:5.1.3.9-RXN xref: RHEA:23932 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047466 name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity namespace: molecular_function alt_id: GO:0018840 def: "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide." [EC:5.2.1.10, RHEA:10924] synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10] synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-] synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-] xref: EC:5.2.1.10 xref: KEGG_REACTION:R04576 xref: MetaCyc:5.2.1.10-RXN xref: RHEA:10924 xref: UM-BBD_reactionID:r0278 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047467 name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN] is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047468 name: phosphoglucomutase (glucose-cofactor) activity namespace: molecular_function def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN] synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5] synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5] xref: EC:5.4.2.5 xref: MetaCyc:5.4.2.5-RXN is_a: GO:0004614 ! phosphoglucomutase activity [Term] id: GO:0047469 name: 4-carboxymethyl-4-methylbutenolide mutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, RHEA:19237] synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14] synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14] xref: EC:5.4.99.14 xref: KEGG_REACTION:R04510 xref: MetaCyc:5.4.99.14-RXN xref: RHEA:19237 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047470 name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN] synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15] synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15] synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15] xref: EC:5.4.99.15 xref: MetaCyc:5.4.99.15-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047471 name: maltose alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN] synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16] synonym: "trehalose synthase activity" RELATED [EC:5.4.99.16] xref: EC:5.4.99.16 xref: MetaCyc:5.4.99.16-RXN xref: RHEA:15145 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047472 name: 3-carboxy-cis,cis-muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)." [EC:5.5.1.2, RHEA:23656] synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2] synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] synonym: "CMLE activity" EXACT [EC:5.5.1.2] xref: EC:5.5.1.2 xref: KEGG_REACTION:R03307 xref: MetaCyc:5.5.1.2-RXN xref: RHEA:23656 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047473 name: D-alanine [D-alanyl carrier protein] ligase activity namespace: molecular_function def: "Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate." [GOC:pg] comment: https://github.com/geneontology/go-ontology/issues/14237 synonym: "D-alanine-activating enzyme activity" RELATED [] synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.2.1] synonym: "D-alanine-poly(phosphoribitol) ligase activity" BROAD [] synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" BROAD [] xref: EC:6.2.1 xref: MetaCyc:6.2.1.M5-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047474 name: long-chain fatty acid luciferin component ligase activity namespace: molecular_function def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN] synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19] synonym: "long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT [] synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19] xref: EC:6.2.1.19 xref: MetaCyc:6.2.1.19-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047475 name: phenylacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA." [EC:6.2.1.30, RHEA:20956] synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30] synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30] synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30] xref: EC:6.2.1.30 xref: KEGG_REACTION:R02539 xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN xref: RHEA:20956 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047476 name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28] synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28] synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28] xref: EC:6.2.1.28 xref: MetaCyc:6.2.1.28-RXN xref: RHEA:21776 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047478 name: aspartate-ammonia ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate." [EC:6.3.1.4, RHEA:14197] synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4] synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4] synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4] xref: EC:6.3.1.4 xref: KEGG_REACTION:R00482 xref: MetaCyc:6.3.1.4-RXN xref: RHEA:14197 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047479 name: trypanothione synthase activity namespace: molecular_function def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN] synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9] synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9] xref: EC:6.3.1.9 xref: MetaCyc:6.3.1.9-RXN xref: RHEA:21532 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047480 name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN] comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10] synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT [] synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] xref: EC:6.3.2.10 xref: MetaCyc:6.3.2.10-RXN xref: RHEA:16085 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047481 name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity namespace: molecular_function def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN] synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16] synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] xref: EC:6.3.2.16 xref: MetaCyc:6.3.2.16-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047482 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine." [EC:6.3.2.7, RHEA:17969] synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7] synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7] synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7] xref: EC:6.3.2.7 xref: KEGG_REACTION:R02786 xref: MetaCyc:6.3.2.7-RXN xref: RHEA:17969 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047483 name: imidazoleacetate-phosphoribosyldiphosphate ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate." [EC:6.3.4.8, RHEA:16485] synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8] synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8] xref: EC:6.3.4.8 xref: KEGG_REACTION:R04068 xref: MetaCyc:6.3.4.8-RXN xref: RHEA:16485 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047484 name: regulation of response to osmotic stress namespace: biological_process def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006970 ! response to osmotic stress relationship: regulates GO:0006970 ! response to osmotic stress [Term] id: GO:0047485 name: protein N-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] synonym: "amino-terminal binding" RELATED [GOC:jsg] synonym: "amino-terminus binding" RELATED [GOC:jsg] synonym: "N-terminal binding" EXACT [] synonym: "N-terminal end binding" EXACT [GOC:jsg] synonym: "NH2-terminal binding" NARROW [GOC:jsg] synonym: "NH2-terminus binding" NARROW [GOC:jsg] is_a: GO:0005515 ! protein binding [Term] id: GO:0047486 name: chondroitin ABC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [GOC:hjd] is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047487 name: oligogalacturonide lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN] synonym: "OGTE" RELATED [EC:4.2.2.6] synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6] synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6] xref: EC:4.2.2.6 xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN xref: RHEA:20269 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047488 name: heparin lyase activity namespace: molecular_function def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN] synonym: "heparan sulfate lyase activity" RELATED [] synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7] synonym: "heparinase activity" EXACT [EC:4.2.2.7] xref: EC:4.2.2.7 xref: MetaCyc:4.2.2.7-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047489 name: pectate disaccharide-lyase activity namespace: molecular_function def: "Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9] synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9] synonym: "exo-PATE" RELATED [EC:4.2.2.9] synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9] synonym: "exo-PGL" RELATED [EC:4.2.2.9] synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9] synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9] synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9] synonym: "PATE activity" EXACT [EC:4.2.2.9] synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9] xref: EC:4.2.2.9 xref: MetaCyc:4.2.2.9-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047490 name: pectin lyase activity namespace: molecular_function def: "Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10] synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10] synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10] synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10] synonym: "pectolyase activity" EXACT [EC:4.2.2.10] synonym: "PL activity" EXACT [EC:4.2.2.10] synonym: "PMGL activity" EXACT [EC:4.2.2.10] synonym: "PNL activity" EXACT [EC:4.2.2.10] synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10] xref: EC:4.2.2.10 xref: MetaCyc:4.2.2.10-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047491 name: poly(alpha-L-guluronate) lyase activity namespace: molecular_function def: "Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11] synonym: "alginase II activity" RELATED [EC:4.2.2.11] synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11] synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11] synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11] synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11] xref: EC:4.2.2.11 xref: MetaCyc:4.2.2.11-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047492 name: xanthan lyase activity namespace: molecular_function def: "Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12] xref: EC:4.2.2.12 xref: MetaCyc:4.2.2.12-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0047493 name: ceramide cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin." [EC:2.7.8.3, RHEA:16273] synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3] synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3] xref: EC:2.7.8.3 xref: KEGG_REACTION:R01891 xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN xref: RHEA:16273 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047494 name: serine-phosphoethanolamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+)." [EC:2.7.8.4, RHEA:22656] synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4] synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4] synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4] synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4] xref: EC:2.7.8.4 xref: KEGG_REACTION:R02563 xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN xref: RHEA:22656 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047495 name: membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21] synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21] synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21] synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21] xref: EC:2.7.8.21 xref: MetaCyc:2.7.8.21-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0047496 name: vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:0099518 ! vesicle cytoskeletal trafficking [Term] id: GO:0047497 name: mitochondrion transport along microtubule namespace: biological_process def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] synonym: "mitochondrial migration along microtubule" EXACT [] synonym: "mitochondrial transport along microtubule" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0047498 name: calcium-dependent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4] synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW [] synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW [] xref: Reactome:R-HSA-111883 "Hydrolysis of phosphatidylcholine" is_a: GO:0004623 ! phospholipase A2 activity [Term] id: GO:0047499 name: calcium-independent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4] subset: goslim_chembl synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] xref: Reactome:R-HSA-8952251 "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)" is_a: GO:0004623 ! phospholipase A2 activity [Term] id: GO:0047500 name: (+)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH." [EC:1.1.1.198, RHEA:17329] synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198] synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198] xref: EC:1.1.1.198 xref: KEGG_REACTION:R02944 xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN xref: RHEA:17329 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047501 name: (+)-neomenthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.208, RHEA:23812] synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208] xref: EC:1.1.1.208 xref: KEGG_REACTION:R02548 xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN xref: RHEA:23812 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047502 name: (+)-sabinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH." [EC:1.1.1.228, RHEA:18329] synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228] synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228] xref: EC:1.1.1.228 xref: KEGG_REACTION:R03745 xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN xref: RHEA:18329 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047503 name: (-)-borneol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH." [EC:1.1.1.227, RHEA:22128] synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227] xref: EC:1.1.1.227 xref: KEGG_REACTION:R02945 xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN xref: RHEA:22128 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047504 name: (-)-menthol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.207, RHEA:13917] synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207] synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207] xref: EC:1.1.1.207 xref: KEGG_REACTION:R02177 xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN xref: RHEA:13917 xref: UM-BBD_reactionID:r1182 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047505 name: (-)-menthol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+)." [EC:1.14.13.46, RHEA:11648] synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46] synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46] xref: EC:1.14.13.46 xref: KEGG_REACTION:R02178 xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN xref: RHEA:11648 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047506 name: (deoxy)adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN] synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11] xref: EC:2.7.4.11 xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN xref: RHEA:23100 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047507 name: (deoxy)nucleoside-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN] synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13] synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13] xref: EC:2.7.4.13 xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN xref: RHEA:11216 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0047508 name: (R)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O." [EC:4.2.1.35, RHEA:22332] synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35] synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35] synonym: "citraconase activity" EXACT [EC:4.2.1.35] synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35] synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] xref: EC:4.2.1.35 xref: KEGG_REACTION:R03896 xref: MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN xref: RHEA:22332 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047509 name: (R)-dehydropantoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH." [EC:1.2.1.33, RHEA:19349] synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33] synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33] xref: EC:1.2.1.33 xref: KEGG_REACTION:R03198 xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN xref: RHEA:19349 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047510 name: (S)-2-methylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate = H(2)O + mesaconate." [EC:4.2.1.34, RHEA:13529] synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34] synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34] synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34] synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34] synonym: "mesaconase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34] synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34] xref: EC:4.2.1.34 xref: KEGG_REACTION:R03693 xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN xref: RHEA:13529 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047511 name: (S)-methylmalonyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate." [EC:3.1.2.17, RHEA:17345] synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17] xref: EC:3.1.2.17 xref: KEGG_REACTION:R02764 xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN xref: RHEA:17345 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047512 name: (S,S)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH." [EC:1.1.1.76, RHEA:12184] synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76] synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76] synonym: "L-BDH" RELATED [EC:1.1.1.76] synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76] xref: EC:1.1.1.76 xref: KEGG_REACTION:R03707 xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN xref: RHEA:12184 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047513 name: 1,2-alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN] synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63] synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63] synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63] xref: EC:3.2.1.63 xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN xref: RHEA:10816 is_a: GO:0004560 ! alpha-L-fucosidase activity [Term] id: GO:0047514 name: 1,3-beta-D-glucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN] synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97] synonym: "1,3-beta-glucan phosphorylase activity" EXACT [] synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97] synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97] xref: EC:2.4.1.97 xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047515 name: 1,3-beta-oligoglucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN] synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30] xref: EC:2.4.1.30 xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047516 name: 1,3-propanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN] synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202] synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202] xref: EC:1.1.1.202 xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN xref: RHEA:23188 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047517 name: 1,4-beta-D-xylan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN] synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24] xref: EC:2.4.2.24 xref: MetaCyc:RXN-9104 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047518 name: 1-methyladenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose." [EC:3.2.2.13, RHEA:12865] synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13] synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13] xref: EC:3.2.2.13 xref: KEGG_REACTION:R03885 xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN xref: RHEA:12865 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047519 name: quinate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol." [RHEA:23672] synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.5.8] synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.5.8] synonym: "quinate:quinone 3-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.8] xref: EC:1.1.5.8 xref: KEGG_REACTION:R01873 xref: MetaCyc:1.1.99.25-RXN xref: RHEA:23672 is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0047520 name: 11-cis-retinyl-palmitate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate." [EC:3.1.1.63, RHEA:19697] synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63] synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63] synonym: "RPH" RELATED [EC:3.1.1.63] xref: EC:3.1.1.63 xref: KEGG_REACTION:R03049 xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN xref: Reactome:R-HSA-2465941 "A REH hydrolyses 11cRE to 11cROL" xref: RHEA:19697 is_a: GO:0052689 ! carboxylic ester hydrolase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0047521 name: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.238, RHEA:21424] synonym: "12-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238] xref: EC:1.1.1.238 xref: KEGG_REACTION:R03495 xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: RHEA:21424 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047522 name: 15-oxoprostaglandin 13-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] comment: Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'. synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48] xref: EC:1.3.1.48 xref: KEGG_REACTION:R04556 xref: KEGG_REACTION:R04557 xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047524 name: 16-hydroxysteroid epimerase activity namespace: molecular_function def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN] synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2] xref: EC:5.1.99.2 xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0047525 name: 2'-hydroxydaidzein reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN] synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] synonym: "HDR activity" EXACT [EC:1.3.1.51] synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51] xref: EC:1.3.1.51 xref: MetaCyc:RXN-4502 xref: RHEA:17145 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047526 name: 2'-hydroxyisoflavone reductase activity namespace: molecular_function def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN] synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45] synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45] synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45] xref: EC:1.3.1.45 xref: MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN xref: RHEA:22560 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047527 name: 2,3-dihydroxybenzoate-serine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN] synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14] synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14] synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14] xref: EC:6.3.2.14 xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047528 name: 2,3-dihydroxyindole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+)." [EC:1.13.11.23, RHEA:19445] synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23] xref: EC:1.13.11.23 xref: KEGG_REACTION:R00983 xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN xref: RHEA:19445 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047529 name: 2,3-dimethylmalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, RHEA:10472] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32] synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] xref: EC:4.1.3.32 xref: KEGG_REACTION:R01355 xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN xref: RHEA:10472 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047530 name: 2,4-diaminopentanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN] synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12] synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12] xref: EC:1.4.1.12 xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047531 name: 2,5-diaminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, RHEA:16017] synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "2,5-diaminovalerate aminotransferase activity" EXACT [] synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8] synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8] synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8] xref: EC:2.6.1.8 xref: KEGG_REACTION:R03248 xref: MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN xref: RHEA:16017 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047532 name: 2,5-dioxopiperazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine." [EC:3.5.2.13, RHEA:21808] synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13] synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13] xref: EC:3.5.2.13 xref: KEGG_REACTION:R03810 xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN xref: RHEA:21808 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047533 name: 2,5-dioxovalerate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, IMG:03338, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN] synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26] synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] xref: EC:1.2.1.26 xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN xref: RHEA:11296 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047534 name: 2-acetolactate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN] synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3] synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3] xref: EC:5.4.99.3 xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047535 name: 2-alkyn-1-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH." [EC:1.1.1.165, RHEA:19101] synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165] xref: EC:1.1.1.165 xref: KEGG_REACTION:R03963 xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN xref: RHEA:19101 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047536 name: 2-aminoadipate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601] synonym: "2-aminoadipate aminotransferase activity" EXACT [] synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39] synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39] synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39] synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39] xref: EC:2.6.1.39 xref: KEGG_REACTION:R01939 xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-508561 "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate" xref: Reactome:R-HSA-70952 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate" xref: RHEA:12601 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047537 name: 2-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN] synonym: "2-aminohexanoate aminotransferase activity" EXACT [] synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67] synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67] xref: EC:2.6.1.67 xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN xref: RHEA:23600 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047538 name: 2-carboxy-D-arabinitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, RHEA:17837] synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63] synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63] xref: EC:3.1.3.63 xref: KEGG_REACTION:R04167 xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN xref: RHEA:17837 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047539 name: 2-deoxyglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN] synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112] synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112] xref: EC:3.2.1.112 xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0047540 name: 2-enoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN] synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31] synonym: "enoate reductase activity" EXACT [EC:1.3.1.31] xref: EC:1.3.1.31 xref: MetaCyc:2-ENOATE-REDUCTASE-RXN xref: RHEA:10200 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047541 name: 2-furoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.31, RHEA:19269] synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31] synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31] xref: EC:6.2.1.31 xref: KEGG_REACTION:R02986 xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN xref: RHEA:19269 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047542 name: 2-furoyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+)." [EC:1.3.99.8, RHEA:21480] synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8] xref: EC:1.3.99.8 xref: KEGG_REACTION:R02987 xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN xref: RHEA:21480 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047543 name: 2-hexadecenal reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH." [EC:1.3.1.27, RHEA:12444] synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27] synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27] xref: EC:1.3.1.27 xref: KEGG_REACTION:R02463 xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN xref: RHEA:12444 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047544 name: 2-hydroxybiphenyl 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [EC:1.14.13.44, RHEA:11996] synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44] xref: EC:1.14.13.44 xref: KEGG_REACTION:R03964 xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN xref: RHEA:11996 xref: UM-BBD_reactionID:r1423 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047545 name: 2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2] synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2] xref: EC:1.1.99.2 xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-880050 "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2" xref: RHEA:21252 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047546 name: 2-hydroxypyridine 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O." [EC:1.14.99.26, RHEA:16973] synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26] synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26] xref: EC:1.14.99.26 xref: KEGG_REACTION:R03206 xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN xref: RHEA:16973 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047547 name: 2-methylcitrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.79, RHEA:17725] synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79] synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79] synonym: "prpD" RELATED [EC:4.2.1.79] xref: EC:4.2.1.79 xref: KEGG_REACTION:R04424 xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN xref: RHEA:17725 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047548 name: 2-methyleneglutarate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13793] synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4] synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4] xref: EC:5.4.99.4 xref: KEGG_REACTION:R03908 xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN xref: RHEA:13793 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047549 name: 2-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite." [EC:1.14.13.31, RHEA:19457] synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31] synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31] synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31] xref: EC:1.14.13.31 xref: KEGG_REACTION:R00828 xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN xref: RHEA:19457 xref: UM-BBD_reactionID:r1494 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047550 name: 2-oxoadipate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH." [EC:1.1.1.172, RHEA:14793] synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172] synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172] synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172] xref: EC:1.1.1.172 xref: KEGG_REACTION:R01932 xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN xref: RHEA:14793 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047551 name: 2-oxoaldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23] synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23] synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23] synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] xref: EC:1.2.1.23 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN xref: RHEA:22276 xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+) is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0047552 name: 2-oxoaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN] synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49] synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49] synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49] synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] xref: EC:1.2.1.49 xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: RHEA:18129 is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity [Term] id: GO:0047553 name: 2-oxoglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN] synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3] synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3] synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] synonym: "KGOR activity" EXACT [EC:1.2.7.3] xref: EC:1.2.7.3 xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0047554 name: 2-pyrone-4,6-dicarboxylate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+)." [EC:3.1.1.57, RHEA:10644] synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57] xref: EC:3.1.1.57 xref: KEGG_REACTION:R04277 xref: MetaCyc:RXN-2462 xref: RHEA:10644 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047555 name: 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function alt_id: GO:0004116 def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN] synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35] synonym: "cGMP phosphodiesterase activity" EXACT [] synonym: "cGMP-PDE" RELATED [EC:3.1.4.35] synonym: "cGMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic GMP phosphodiesterase activity" EXACT [] synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT [] xref: EC:3.1.4.35 xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN xref: Reactome:R-HSA-4086392 "PDE6 hydrolyses cGMP to GMP" xref: Reactome:R-HSA-418456 "cGMP is degraded by PDEs" xref: Reactome:R-HSA-74059 "PDE6 hydrolyses cGMP to GMP" xref: RHEA:16957 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0047556 name: 3,4-dihydroxyphthalate decarboxylase activity namespace: molecular_function alt_id: GO:0034913 def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2)." [EC:4.1.1.69, RHEA:18601] synonym: "3,4-dihydroxyphthalate 2-decarboxylase activity" EXACT [] synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69] synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69] xref: EC:4.1.1.69 xref: KEGG_REACTION:R01634 xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN xref: RHEA:18601 xref: UM-BBD_reactionID:r1447 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047557 name: 3-aci-nitropropanoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite." [EC:1.7.3.5, RHEA:22372] synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5] synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5] xref: EC:1.7.3.5 xref: KEGG_REACTION:R01609 xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN xref: RHEA:22372 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047558 name: 3-cyanoalanine hydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+)." [EC:4.2.1.65, RHEA:15385] synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65] synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65] synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65] synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65] xref: EC:4.2.1.65 xref: KEGG_REACTION:R01267 xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN xref: RHEA:15385 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047559 name: 3-dehydro-L-gulonate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN] synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130] synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130] synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130] synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130] xref: EC:1.1.1.130 xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047560 name: 3-dehydrosphinganine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH." [EC:1.1.1.102, RHEA:22640] synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102] synonym: "DSR activity" EXACT [EC:1.1.1.102] synonym: "KTS reductase activity" RELATED [EC:1.1.1.102] xref: EC:1.1.1.102 xref: KEGG_REACTION:R02978 xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN xref: Reactome:R-HSA-428123 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+" xref: RHEA:22640 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047561 name: 3-hydroxyanthranilate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2)." [EC:1.10.3.5, RHEA:17245] synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5] synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5] xref: EC:1.10.3.5 xref: KEGG_REACTION:R02666 xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN xref: RHEA:17245 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0047562 name: 3-hydroxyaspartate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, RHEA:14377] synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14] synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14] synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14] xref: EC:4.1.3.14 xref: KEGG_REACTION:R00478 xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN xref: RHEA:14377 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047563 name: 3-hydroxybenzoate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O." [EC:1.14.99.23, RHEA:14193] synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23] synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23] xref: EC:1.14.99.23 xref: KEGG_REACTION:R01508 xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN xref: RHEA:14193 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047564 name: 3-hydroxycyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione." [EC:1.1.99.26, RHEA:15905] synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26] xref: EC:1.1.99.26 xref: KEGG_REACTION:R03212 xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN xref: RHEA:15905 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047565 name: 3-hydroxypropionate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH." [EC:1.1.1.59, RHEA:13357] synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59] xref: EC:1.1.1.59 xref: KEGG_REACTION:R01608 xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN xref: RHEA:13357 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047566 name: 3-ketovalidoxylamine C-N-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+)." [EC:4.3.3.1, RHEA:22768] synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1] synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1] synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1] xref: EC:4.3.3.1 xref: KEGG_REACTION:R04367 xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN xref: RHEA:22768 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0047567 name: 3-methyleneoxindole reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH." [EC:1.3.1.17, RHEA:20257] synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] xref: EC:1.3.1.17 xref: KEGG_REACTION:R03930 xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN xref: RHEA:20257 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047568 name: 3-oxo-5-beta-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN] synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6] xref: EC:1.3.99.6 xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0047569 name: 3-oxoadipate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN] synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6] synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6] xref: EC:2.8.3.6 xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN xref: RHEA:12048 xref: UM-BBD_reactionID:r1050 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047570 name: 3-oxoadipate enol-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN] synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24] synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24] xref: EC:3.1.1.24 xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN xref: RHEA:10184 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047571 name: 3-oxosteroid 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN] synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4] synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4] xref: EC:1.3.99.4 xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0712 is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0047572 name: 3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.38, RHEA:12412] synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38] synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38] xref: EC:3.1.3.38 xref: KEGG_REACTION:R01511 xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:12412 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047573 name: 4-acetamidobutyrate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63] xref: EC:3.5.1.63 xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN xref: RHEA:15897 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047574 name: 4-acetamidobutyryl-CoA deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate." [EC:3.5.1.51, RHEA:22928] synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51] synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51] synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51] xref: EC:3.5.1.51 xref: KEGG_REACTION:R04056 xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN xref: RHEA:22928 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047575 name: 4-carboxymuconolactone decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2)." [EC:4.1.1.44, RHEA:23348] synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44] synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44] xref: EC:4.1.1.44 xref: KEGG_REACTION:R03470 xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN xref: RHEA:23348 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047576 name: 4-chlorobenzoate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+)." [EC:3.8.1.6, RHEA:23440] synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6] synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6] xref: EC:3.8.1.6 xref: KEGG_REACTION:R01307 xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN xref: RHEA:23440 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0047577 name: 4-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde." [EC:1.1.1.61, RHEA:23948] synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61] synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61] xref: EC:1.1.1.61 xref: KEGG_REACTION:R01644 xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: RHEA:23948 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047578 name: 4-hydroxyglutamate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN] synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23] synonym: "4-hydroxyglutamate aminotransferase activity" EXACT [] xref: EC:2.6.1.23 xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-6784393 "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)" xref: RHEA:10480 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047579 name: 4-hydroxymandelate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2)." [EC:1.1.3.19, RHEA:15833] synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19] synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19] xref: EC:1.1.3.19 xref: KEGG_REACTION:R02673 xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN xref: RHEA:15833 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047580 name: 4-hydroxyproline epimerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, RHEA:21152] synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] xref: EC:5.1.1.8 xref: KEGG_REACTION:R03296 xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN xref: RHEA:21152 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047581 name: 4-methyleneglutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+)." [EC:6.3.1.7, RHEA:13853] synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7] synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7] xref: EC:6.3.1.7 xref: KEGG_REACTION:R02711 xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN xref: RHEA:13853 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047582 name: 4-methyleneglutaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+)." [EC:3.5.1.67, RHEA:14741] synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67] synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67] xref: EC:3.5.1.67 xref: KEGG_REACTION:R02712 xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN xref: RHEA:14741 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047583 name: 4-methyloxaloacetate esterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate." [EC:3.1.1.44, RHEA:10564] synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44] xref: EC:3.1.1.44 xref: KEGG_REACTION:R01144 xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN xref: RHEA:10564 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047584 name: 4-oxalmesaconate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O." [EC:4.2.1.83, RHEA:17401] synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83] synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83] synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] xref: EC:4.2.1.83 xref: KEGG_REACTION:R04478 xref: MetaCyc:RXN-2463 xref: RHEA:17401 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047585 name: 4-pyridoxolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+)." [EC:3.1.1.27, RHEA:14301] synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27] xref: EC:3.1.1.27 xref: KEGG_REACTION:R02992 xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN xref: RHEA:14301 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047586 name: 5'-acylphosphoadenosine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN] synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20] synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20] xref: EC:3.6.1.20 xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN xref: RHEA:16837 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0047587 name: 5-alpha-hydroxysteroid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O." [EC:4.2.1.62, RHEA:22064] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62] synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62] synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62] xref: EC:4.2.1.62 xref: KEGG_REACTION:R03675 xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN xref: RHEA:22064 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047588 name: 5-aminopentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN] synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30] synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30] synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30] xref: EC:3.5.1.30 xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN xref: RHEA:15677 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047589 name: 5-aminovalerate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, RHEA:10212] synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "5-aminovalerate aminotransferase activity" EXACT [] synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48] synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48] xref: EC:2.6.1.48 xref: KEGG_REACTION:R02274 xref: MetaCyc:VAGL-RXN xref: RHEA:10212 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047590 name: 5-dehydro-2-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN] synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92] synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92] synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92] synonym: "DKH kinase activity" EXACT [EC:2.7.1.92] xref: EC:2.7.1.92 xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN xref: RHEA:13497 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047591 name: 5-hydroxypentanoate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate." [EC:2.8.3.14, RHEA:23496] synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14] synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14] synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14] xref: EC:2.8.3.14 xref: KEGG_REACTION:R04057 xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN xref: RHEA:23496 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047592 name: 5-pyridoxate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)." [EC:1.14.12.5, RHEA:11152] synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5] synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5] xref: EC:1.14.12.5 xref: KEGG_REACTION:R04570 xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN xref: RHEA:11152 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0047593 name: 6-acetylglucose deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+)." [EC:3.1.1.33, RHEA:18485] synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33] synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33] xref: EC:3.1.1.33 xref: KEGG_REACTION:R00327 xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN xref: RHEA:18485 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047594 name: 6-beta-hydroxyhyoscyamine epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate." [EC: 1.14.20.13, RHEA:12797] synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC: 1.14.20.13] synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.20.13] synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.20.13] xref: EC:1.14.20.13 xref: KEGG_REACTION:R03737 xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN xref: RHEA:12797 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0047595 name: 6-hydroxynicotinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN] synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "HNA reductase activity" EXACT [EC:1.3.7.1] xref: EC:1.3.7.1 xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0047596 name: 6-methylsalicylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2)." [EC:4.1.1.52, RHEA:23112] synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52] synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52] synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52] xref: EC:4.1.1.52 xref: KEGG_REACTION:R03567 xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN xref: RHEA:23112 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047597 name: 6-oxocineole dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+)." [EC:1.14.13.51, RHEA:24324] synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51] synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51] xref: EC:1.14.13.51 xref: KEGG_REACTION:R02995 xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN xref: RHEA:24324 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047598 name: 7-dehydrocholesterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21] synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21] synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21] synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21] synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21] xref: EC:1.3.1.21 xref: MetaCyc:RXN66-323 xref: Reactome:R-HSA-196402 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol" xref: Reactome:R-HSA-6807055 "DHCR7 reduces 7-dehydroCHOL to CHOL" xref: RHEA:23984 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047599 name: 8-oxocoformycin reductase activity namespace: molecular_function def: "Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH." [EC:1.1.1.235, RHEA:23168] synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235] synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235] xref: EC:1.1.1.235 xref: KEGG_REACTION:R03667 xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN xref: RHEA:23168 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047600 name: abequosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN] synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60] synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60] xref: EC:2.4.1.60 xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047601 name: acetate kinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." [EC:2.7.2.12, RHEA:24276] synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12] synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12] synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12] xref: EC:2.7.2.12 xref: KEGG_REACTION:R00320 xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN xref: RHEA:24276 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047602 name: acetoacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2)." [EC:4.1.1.4, RHEA:19729] synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4] synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4] synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4] xref: EC:4.1.1.4 xref: KEGG_REACTION:R01366 xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN xref: RHEA:19729 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047603 name: acetoacetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+)." [EC:3.1.2.11, RHEA:15673] synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11] synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11] xref: EC:3.1.2.11 xref: KEGG_REACTION:R01358 xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN xref: RHEA:15673 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047604 name: acetoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, RHEA:12092] synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4] xref: EC:5.1.2.4 xref: KEGG_REACTION:R02949 xref: MetaCyc:ACETOIN-RACEMASE-RXN xref: RHEA:12092 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0047605 name: acetolactate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN] synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5] synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5] synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5] xref: EC:4.1.1.5 xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN xref: RHEA:21580 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047606 name: hydroxynitrilase activity namespace: molecular_function alt_id: GO:0046991 def: "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone." [EC:4.1.2, GOC:mah, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "(S)-acetone-cyanohydrin lyase activity" NARROW [EC:4.1.2.37] synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37] synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanhydrin lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin acetone-lyase activity" NARROW [EC:4.1.2.37] synonym: "acetone-cyanohydrin lyase activity" NARROW [EC:4..1.2.37] synonym: "alpha-hydroxynitrile lyase activity" NARROW [EC:4.1.2.37] synonym: "hydroxynitrile lyase activity" EXACT [] synonym: "oxynitrilase activity" RELATED [EC:4.1.2.37] xref: EC:4.1.2.37 xref: MetaCyc:4.1.2.39-RXN xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047608 name: acetylindoxyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN] synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2] xref: EC:1.7.3.2 xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN xref: RHEA:16941 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047609 name: acetylputrescine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine." [EC:3.5.1.62, RHEA:23412] synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62] xref: EC:3.5.1.62 xref: KEGG_REACTION:R01156 xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN xref: RHEA:23412 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047610 name: acetylsalicylate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate." [EC:3.1.1.55, RHEA:11752] synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55] synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55] synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55] xref: EC:3.1.1.55 xref: KEGG_REACTION:R02942 xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN xref: RHEA:11752 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047611 name: acetylspermidine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine." [EC:3.5.1.48, RHEA:23928] synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48] synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] xref: EC:3.5.1.48 xref: KEGG_REACTION:R07300 xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN xref: RHEA:23928 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0047612 name: acid-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate." [EC:6.2.1.10, RHEA:10968] synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10] synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10] synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10] xref: EC:6.2.1.10 xref: KEGG_REACTION:R00394 xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN xref: RHEA:10968 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047613 name: aconitate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate." [EC:4.1.1.6, RHEA:15253] synonym: "CAD activity" BROAD [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6] synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6] synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6] xref: EC:4.1.1.6 xref: KEGG_REACTION:R02243 xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN xref: RHEA:15253 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047614 name: aconitate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, RHEA:17265] synonym: "aconitate D-isomerase activity" EXACT [] synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7] synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7] xref: EC:5.3.3.7 xref: KEGG_REACTION:R02244 xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN xref: RHEA:17265 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0047615 name: actinomycin lactonase activity namespace: molecular_function def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN] synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39] xref: EC:3.1.1.39 xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047616 name: acyl-CoA dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN] synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8] synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8] synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8] synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] xref: EC:1.3.1.8 xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047617 name: acyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0008778 alt_id: GO:0016291 alt_id: GO:0016292 def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN] synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20] synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20] synonym: "acyl-CoA thioesterase activity" EXACT [] synonym: "acyl-CoA thioesterase I activity" NARROW [] synonym: "acyl-CoA thioesterase II activity" NARROW [] synonym: "acyl-CoA thiolesterase activity" EXACT [] synonym: "thioesterase B" RELATED [EC:3.1.2.20] synonym: "thioesterase II" RELATED [EC:3.1.2.20] xref: EC:3.1.2 xref: EC:3.1.2.20 xref: MetaCyc:ACYL-COA-HYDROLASE-RXN xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA" xref: Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA" xref: Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA" xref: Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT" xref: RHEA:16781 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047618 name: acylagmatine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate." [EC:3.5.1.40, RHEA:15065] synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40] synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] xref: EC:3.5.1.40 xref: KEGG_REACTION:R01425 xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN xref: RHEA:15065 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047619 name: acylcarnitine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN] synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28] synonym: "HACH" RELATED [EC:3.1.1.28] synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] xref: EC:3.1.1.28 xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047620 name: acylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94] synonym: "MGK" RELATED [EC:2.7.1.94] synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94] synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94] synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94] synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] xref: EC:2.7.1.94 xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN xref: Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047621 name: acylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN] synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5] xref: EC:3.7.1.5 xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN xref: UM-BBD_reactionID:r1401 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047622 name: adenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN] synonym: "adenosinase activity" EXACT [EC:3.2.2.7] synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7] synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7] synonym: "ANase activity" EXACT [EC:3.2.2.7] synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7] xref: EC:3.2.2.7 xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN xref: RHEA:18669 is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0047623 name: adenosine-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP." [EC:3.5.4.17, GOC:bf, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN] comment: Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692. synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17] synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17] xref: EC:3.5.4.17 xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047624 name: adenosine-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN] synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14] xref: EC:3.6.1.14 xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN xref: RHEA:24500 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047625 name: adenosylmethionine cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone." [EC:2.5.1.4, RHEA:21932] synonym: "adenosyl methionine cyclotransferase activity" EXACT [] synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4] synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4] xref: EC:2.5.1.4 xref: KEGG_REACTION:R00180 xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN xref: RHEA:21932 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047626 name: adenosylmethionine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+)." [EC:3.3.1.2, RHEA:14645] synonym: "adenosyl methionine hydrolase activity" EXACT [] synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2] synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2] synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2] xref: EC:3.3.1.2 xref: KEGG_REACTION:R00175 xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN xref: RHEA:14645 is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0047627 name: adenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate." [EC:3.6.2.1, RHEA:17041] synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] synonym: "adenylylsulphatase activity" EXACT [] xref: EC:3.6.2.1 xref: KEGG_REACTION:R00531 xref: MetaCyc:ADENYLYLSULFATASE-RXN xref: RHEA:17041 is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: GO:0047628 name: ADP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN] synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118] xref: EC:2.7.1.118 xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047629 name: ADP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN] synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7] synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7] xref: EC:3.5.4.7 xref: MetaCyc:ADP-DEAMINASE-RXN xref: RHEA:12741 is_a: GO:0047623 ! adenosine-phosphate deaminase activity [Term] id: GO:0047630 name: ADP-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate." [EC:3.1.3.28, RHEA:15861] synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28] synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] xref: EC:3.1.3.28 xref: KEGG_REACTION:R03969 xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:15861 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047631 name: ADP-ribose diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN] synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose phosphohydrolase activity" EXACT [] synonym: "ADP-ribose pyrophosphatase activity" EXACT [] synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13] synonym: "ADPR-PPase activity" EXACT [] synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13] synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13] xref: EC:3.6.1.13 xref: MetaCyc:RXN0-1441 xref: Reactome:R-HSA-2393939 "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP" xref: Reactome:R-HSA-2393954 "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP" xref: Reactome:R-HSA-5696049 "ADPRM hydrolyses ADP-ribose to R5P and AMP" xref: RHEA:10412 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047632 name: agmatine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN] synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12] synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12] xref: EC:3.5.3.12 xref: MetaCyc:AGMATINE-DEIMINASE-RXN xref: RHEA:18037 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047633 name: agmatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+)." [EC:2.7.3.10, RHEA:15953] synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10] synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10] xref: EC:2.7.3.10 xref: KEGG_REACTION:R01417 xref: MetaCyc:AGMATINE-KINASE-RXN xref: RHEA:15953 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047634 name: agmatine N4-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+)." [EC:2.3.1.64, RHEA:13405] synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64] synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64] xref: EC:2.3.1.64 xref: KEGG_REACTION:R01617 xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN xref: RHEA:13405 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047635 name: alanine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN] synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "alanine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12] xref: EC:2.6.1.12 xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047636 name: alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.17, RHEA:17589] synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17] synonym: "ADH" RELATED [EC:1.5.1.17] synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17] synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17] synonym: "ALPDH" RELATED [EC:1.5.1.17] synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17] xref: EC:1.5.1.17 xref: KEGG_REACTION:R00398 xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN xref: RHEA:17589 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047637 name: alanylphosphatidylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN] synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11] synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11] synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11] xref: EC:2.3.2.11 xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047638 name: albendazole monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+)." [EC:1.14.13.32, RHEA:10796] synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32] synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32] xref: EC:1.14.13.32 xref: KEGG_REACTION:R03712 xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN xref: RHEA:10796 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047639 name: alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN] comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13] synonym: "AOX activity" EXACT [EC:1.1.3.13] synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13] xref: EC:1.1.3.13 xref: MetaCyc:ALCOHOL-OXIDASE-RXN xref: RHEA:19829 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047640 name: aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN] synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121] synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121] synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121] xref: EC:1.1.1.121 xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047641 name: aldose-6-phosphate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH." [EC:1.1.1.200, RHEA:20037] synonym: "A6PR" RELATED [EC:1.1.1.200] synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200] synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200] xref: EC:1.1.1.200 xref: KEGG_REACTION:R00834 xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN xref: RHEA:20037 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047642 name: aldose beta-D-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN] synonym: "aldose b-D-fructosyltransferase activity" EXACT [] synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162] xref: EC:2.4.1.162 xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0047643 name: alginate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN] synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33] synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33] xref: EC:2.4.1.33 xref: MetaCyc:ALGINATE-SYNTHASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047644 name: alizarin 2-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP." [EC:2.4.1.103, RHEA:20677] synonym: "alizarin 2-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103] synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103] synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103] xref: EC:2.4.1.103 xref: KEGG_REACTION:R03573 xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:20677 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047645 name: alkan-1-ol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20] synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20] xref: EC:1.1.99.20 xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:14685 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047646 name: alkanal monooxygenase (FMN-linked) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN] synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3] synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3] synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3] synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3] xref: EC:1.14.14.3 xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047647 name: alkylacetylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate." [EC:3.1.3.59, RHEA:18221] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59] synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59] synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59] xref: EC:3.1.3.59 xref: KEGG_REACTION:R03454 xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN xref: RHEA:18221 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047648 name: alkylamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium." [EC:3.5.1.39, RHEA:20081] synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39] xref: EC:3.5.1.39 xref: KEGG_REACTION:R03620 xref: MetaCyc:ALKYLAMIDASE-RXN xref: RHEA:20081 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047649 name: alkylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.93, RHEA:16937] synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93] synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93] synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93] xref: EC:2.7.1.93 xref: KEGG_REACTION:R04126 xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN xref: RHEA:16937 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047650 name: alkylglycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+)." [EC:2.7.1.84, RHEA:23088] synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84] synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84] synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84] xref: EC:2.7.1.84 xref: KEGG_REACTION:R03944 xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN xref: RHEA:23088 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047651 name: alkylhalidase activity namespace: molecular_function def: "Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+)." [EC:3.8.1.1, RHEA:13765] synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1] synonym: "halogenase activity" RELATED [EC:3.8.1.1] xref: EC:3.8.1.1 xref: KEGG_REACTION:R03523 xref: MetaCyc:ALKYLHALIDASE-RXN xref: RHEA:13765 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0047652 name: allantoate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN] synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9] synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9] xref: EC:3.5.3.9 xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN xref: RHEA:27485 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047653 name: allantoin racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin." [EC:5.1.99.3, RHEA:10804] xref: EC:5.1.99.3 xref: KEGG_REACTION:R03925 xref: MetaCyc:ALLANTOIN-RACEMASE-RXN xref: RHEA:10804 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0047654 name: alliin lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN] synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4] synonym: "alliinase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4] synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] xref: EC:4.4.1.4 xref: MetaCyc:ALLIIN-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047655 name: allyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH." [EC:1.1.1.54, RHEA:12168] synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54] xref: EC:1.1.1.54 xref: KEGG_REACTION:R03572 xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:12168 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047656 name: alpha,alpha-trehalose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN] synonym: "a,a-trehalose phosphorylase activity" EXACT [] synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64] synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64] xref: EC:2.4.1.64 xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN xref: RHEA:23512 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0047657 name: alpha-1,3-glucan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN] synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183] synonym: "1,3-alpha-glucan synthase activity" EXACT [] synonym: "a-1,3-glucan synthase activity" EXACT [] synonym: "UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183] xref: EC:2.4.1.183 xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047658 name: alpha-amino-acid esterase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN] synonym: "a-amino-acid esterase activity" EXACT [] synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43] synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43] xref: EC:3.1.1.43 xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN xref: Reactome:R-HSA-6784959 "BPHL hydrolyses VACV to ACV" is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047659 name: alpha-santonin 1,2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN] synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47] synonym: "a-santonin 1,2-reductase activity" EXACT [] xref: EC:1.3.1.47 xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047660 name: amidinoaspartase activity namespace: molecular_function def: "Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea." [EC:3.5.3.14, RHEA:14849] synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14] synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14] xref: EC:3.5.3.14 xref: KEGG_REACTION:R00777 xref: MetaCyc:AMIDINOASPARTASE-RXN xref: RHEA:14849 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047661 name: amino-acid racemase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN] synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10] xref: EC:5.1.1.10 xref: MetaCyc:AMINO-ACID-RACEMASE-RXN xref: RHEA:18317 is_a: GO:0036361 ! racemase activity, acting on amino acids and derivatives [Term] id: GO:0047662 name: aminobenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN] synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24] synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24] xref: EC:4.1.1.24 xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047663 name: aminoglycoside 6'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.82, RHEA:16449] synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "AAC(6') activity" RELATED [EC:2.3.1.82] synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82] synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT [] synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82] synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW [] xref: EC:2.3.1.82 xref: KEGG_REACTION:R01889 xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN xref: RHEA:16449 is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0047664 name: aminoimidazolase activity namespace: molecular_function def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN] synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8] synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8] xref: EC:3.5.4.8 xref: MetaCyc:R13-RXN xref: RHEA:24947 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0047665 name: aminolevulinate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, RHEA:12480] synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "aminolevulinate aminotransferase activity" EXACT [] synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] xref: EC:2.6.1.43 xref: KEGG_REACTION:R02271 xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN xref: RHEA:12480 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047666 name: ammonia kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate." [EC:2.7.3.8, RHEA:11024] synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8] synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8] xref: EC:2.7.3.8 xref: KEGG_REACTION:R00141 xref: MetaCyc:AMMONIA-KINASE-RXN xref: RHEA:11024 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047667 name: AMP-thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN] synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114] synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114] xref: EC:2.7.1.114 xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047668 name: amygdalin beta-glucosidase activity namespace: molecular_function alt_id: GO:0080080 def: "Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose." [EC:3.2.1.117, RHEA:14177] synonym: "(R)-amygdalin beta-glucosidase activity" EXACT [] synonym: "amygdalin b-glucosidase activity" EXACT [] synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117] synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117] synonym: "amygdalinase" BROAD [EC:3.2.1.117] xref: EC:3.2.1.117 xref: KEGG_REACTION:R02985 xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN xref: RHEA:14177 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0047669 name: amylosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN] synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4] xref: EC:2.4.1.4 xref: MetaCyc:AMYLOSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047670 name: anhydrotetracycline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+)." [EC:1.14.13.38, RHEA:11976] synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38] synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38] synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38] xref: EC:1.14.13.38 xref: KEGG_REACTION:R04060 xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN xref: RHEA:11976 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047671 name: anthranilate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+)." [EC:2.7.7.55, RHEA:22412] synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55] synonym: "ATP:anthranilate adenylyltransferase activity" EXACT [] synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55] xref: EC:2.7.7.55 xref: KEGG_REACTION:R00979 xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN xref: RHEA:22412 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0047672 name: anthranilate N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA." [EC:2.3.1.144, RHEA:21600] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144] xref: EC:2.3.1.144 xref: KEGG_REACTION:R02453 xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN xref: RHEA:21600 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047673 name: anthranilate N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA." [EC:2.3.1.113, RHEA:17557] synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113] xref: EC:2.3.1.113 xref: KEGG_REACTION:R00989 xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN xref: RHEA:17557 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047674 name: apiose 1-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH." [EC:1.1.1.114, RHEA:15301] synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114] synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114] xref: EC:1.1.1.114 xref: KEGG_REACTION:R03577 xref: MetaCyc:APIOSE-1-REDUCTASE-RXN xref: RHEA:15301 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047675 name: arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.5, RHEA:21836] synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5] synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5] xref: EC:4.2.1.5 xref: KEGG_REACTION:R03032 xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN xref: RHEA:21836 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047676 name: arachidonate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+)." [EC:6.2.1.15, RHEA:19713] synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15] synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15] xref: EC:6.2.1.15 xref: KEGG_REACTION:R01598 xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN xref: RHEA:19713 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047677 name: arachidonate 8(R)-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, RHEA:14985] comment: This activity produces the R-enantiomer of HPETE, 8(R)-HPETE. For the reaction producing the S-enantiomer, see GO:0036403. synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40] synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40] synonym: "arachidonate 8-lipoxygenase activity" BROAD [GOC:lb] synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40] xref: EC:1.13.11.40 xref: KEGG_REACTION:R01594 xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN xref: RHEA:14985 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047678 name: arginine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O." [EC:1.13.12.1, RHEA:10548] synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1] synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1] synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1] synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1] xref: EC:1.13.12.1 xref: KEGG_REACTION:R00559 xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN xref: RHEA:10548 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0047679 name: arginine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN] xref: EC:5.1.1.9 xref: MetaCyc:ARGININE-RACEMASE-RXN xref: RHEA:18069 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047680 name: aryl-acylamidase activity namespace: molecular_function def: "Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+)." [EC:3.5.1.13, RHEA:20297] synonym: "AAA-1" RELATED [EC:3.5.1.13] synonym: "AAA-2" RELATED [EC:3.5.1.13] synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13] synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13] synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13] xref: EC:3.5.1.13 xref: KEGG_REACTION:R01862 xref: MetaCyc:ARYL-ACYLAMIDASE-RXN xref: RHEA:20297 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047681 name: aryl-alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN] synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91] synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91] synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91] xref: EC:1.1.1.91 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047682 name: aryl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN] synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7] synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7] synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] xref: EC:1.1.3.7 xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047683 name: aryl-aldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN] synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30] synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30] xref: EC:1.2.1.30 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity [Term] id: GO:0047684 name: arylamine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] xref: EC:2.4.1.71 xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047685 name: amine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] synonym: "amine sulphotransferase activity" EXACT [] synonym: "arylamine sulfotransferase activity" EXACT [] xref: EC:2.8.2.3 xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047686 name: arylsulfate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN] synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22] synonym: "arylsulphate sulphotransferase activity" EXACT [] synonym: "ASST" RELATED [EC:2.8.2.22] xref: EC:2.8.2.22 xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047687 name: obsolete ascorbate 2,3-dioxygenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-ascorbate + H(2)O + O(2) = L-threonate + 2 H(+) + oxalate." [EC:1.13.11.13, RHEA:21784] comment: This term was made obsolete because EC:1.13.11.13 was deleted; the activity is the sum of several enzymatic and spontaneous reactions. synonym: "AAoxygenase activity" EXACT [] synonym: "ascorbate 2,3-dioxygenase activity" EXACT [] synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [] xref: KEGG_REACTION:R00646 xref: MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN xref: RHEA:21784 is_obsolete: true [Term] id: GO:0047688 name: aspartate 4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN] synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12] synonym: "desulfinase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12] synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12] synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12] xref: EC:4.1.1.12 xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN xref: RHEA:12621 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047689 name: aspartate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, RHEA:14973] synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13] xref: EC:5.1.1.13 xref: KEGG_REACTION:R00491 xref: MetaCyc:ASPARTATE-RACEMASE-RXN xref: RHEA:14973 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0047690 name: aspartyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+)." [EC:2.3.2.7, RHEA:11252] synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7] synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7] synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7] xref: EC:2.3.2.7 xref: KEGG_REACTION:R01485 xref: MetaCyc:ASPARTYLTRANSFERASE-RXN xref: RHEA:11252 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047691 name: aspulvinone dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate." [EC:2.5.1.35, RHEA:13809] synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35] synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35] xref: EC:2.5.1.35 xref: KEGG_REACTION:R03799 xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN xref: RHEA:13809 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047692 name: ATP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN] synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18] synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18] xref: EC:3.5.4.18 xref: MetaCyc:ATP-DEAMINASE-RXN xref: RHEA:13037 is_a: GO:0047623 ! adenosine-phosphate deaminase activity [Term] id: GO:0047693 name: ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN] synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8] synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8] synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8] synonym: "ATP pyrophosphatase activity" EXACT [] xref: EC:3.6.1.8 xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN xref: RHEA:14245 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0047694 name: barbiturase activity namespace: molecular_function def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN] synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1] xref: EC:3.5.2.1 xref: MetaCyc:BARBITURASE-RXN xref: RHEA:18653 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047695 name: benzoin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, RHEA:21460] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38] synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38] synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] xref: EC:4.1.2.38 xref: KEGG_REACTION:R00027 xref: MetaCyc:BENZOIN-ALDOLASE-RXN xref: RHEA:21460 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047696 name: beta-adrenergic receptor kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN] synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15] synonym: "ADRBK1" RELATED [EC:2.7.11.15] synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15] synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15] synonym: "BARK1" RELATED [EC:2.7.11.15] synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15] synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15] synonym: "beta-ARK" RELATED [EC:2.7.11.15] synonym: "beta-ARK 1" RELATED [EC:2.7.11.15] synonym: "beta-ARK 2" RELATED [EC:2.7.11.15] synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15] synonym: "beta2ARK" RELATED [EC:2.7.11.15] synonym: "betaARK1" RELATED [EC:2.7.11.15] synonym: "GRK2" RELATED [EC:2.7.11.15] synonym: "GRK3" RELATED [EC:2.7.11.15] synonym: "STK15" RELATED [EC:2.7.11.15] xref: EC:2.7.11.15 xref: Reactome:R-HSA-8851797 "ADRB2 in ADRB2:GRK complex is phosphorylated" xref: Reactome:R-HSA-8866268 "ADBRK1,2 phosphorylate AVPR2" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047697 name: beta-alanopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.26, RHEA:21684] synonym: "b-alanopine dehydrogenase activity" EXACT [] synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26] xref: EC:1.5.1.26 xref: KEGG_REACTION:R00906 xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN xref: RHEA:21684 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047698 name: beta-alanyl-CoA ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN] synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT [] synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6] synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6] xref: EC:4.3.1.6 xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN xref: RHEA:12416 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047699 name: beta-diketone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one." [EC:3.7.1.7, RHEA:11908] synonym: "b-diketone hydrolase activity" EXACT [] synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7] synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7] xref: EC:3.7.1.7 xref: KEGG_REACTION:R03781 xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN xref: RHEA:11908 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047700 name: beta-glucoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN] synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85] synonym: "b-glucoside kinase activity" EXACT [] synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85] xref: EC:2.7.1.85 xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN xref: RHEA:21944 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047701 name: beta-L-arabinosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN] synonym: "b-L-arabinosidase activity" EXACT [] synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88] synonym: "vicianosidase activity" EXACT [EC:3.2.1.88] xref: EC:3.2.1.88 xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047702 name: beta-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, RHEA:21736] synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3] synonym: "b-lysine 5,6-aminomutase activity" EXACT [] synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3] synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3] xref: EC:5.4.3.3 xref: KEGG_REACTION:R03275 xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN xref: RHEA:21736 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047703 name: beta-nitroacrylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH." [EC:1.3.1.16, RHEA:23892] synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16] synonym: "b-nitroacrylate reductase activity" EXACT [] xref: EC:1.3.1.16 xref: KEGG_REACTION:R03900 xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN xref: RHEA:23892 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047704 name: bile-salt sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "BAST I activity" NARROW [EC:2.8.2.14] synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047705 name: bilirubin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O." [EC:1.3.3.5, RHEA:20980] synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5] synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5] xref: EC:1.3.3.5 xref: KEGG_REACTION:R02394 xref: MetaCyc:BILIRUBIN-OXIDASE-RXN xref: RHEA:20980 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0047706 name: biochanin-A reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH." [EC:1.3.1.46, RHEA:12817] synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46] xref: EC:1.3.1.46 xref: KEGG_REACTION:R02954 xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN xref: RHEA:12817 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047707 name: biotin-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN] synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11] synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11] synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11] xref: EC:6.2.1.11 xref: MetaCyc:BIOTIN--COA-LIGASE-RXN xref: RHEA:19681 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047708 name: biotinidase activity namespace: molecular_function def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN] synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12] synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12] xref: EC:3.5.1.12 xref: MetaCyc:BIOTINIDASE-RXN xref: Reactome:R-HSA-3076905 "Extracellular BTD hydrolyses BCTN" xref: Reactome:R-HSA-3325540 "Defective extracellular BTD does not hydrolyse BCTN" xref: Reactome:R-HSA-4167509 "Mitochondrial BTD hydrolyses BCTN" xref: Reactome:R-HSA-4225086 "Defective mitochondrial BTD does not hydrolyse BCTN" xref: RHEA:13081 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047709 name: bis(2-ethylhexyl)phthalate esterase activity namespace: molecular_function def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)." [EC:3.1.1.60, RHEA:15529] synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60] synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60] xref: EC:3.1.1.60 xref: KEGG_REACTION:R04202 xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN xref: RHEA:15529 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047710 name: bis(5'-adenosyl)-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [EC:3.6.1.29, RHEA:13893] synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29] synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29] synonym: "AP3Aase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29] synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29] synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] xref: EC:3.6.1.29 xref: KEGG_REACTION:R00187 xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN xref: RHEA:13893 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0047711 name: blasticidin-S deaminase activity namespace: molecular_function def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN] synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23] xref: EC:3.5.4.23 xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN xref: RHEA:10148 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047712 name: Cypridina-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6] synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6] synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6] synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6] synonym: "luciferase activity" BROAD [EC:1.13.12.6] xref: EC:1.13.12.6 xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN xref: RHEA:22760 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0047713 name: galactitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH." [EC:1.1.1.16, RHEA:20685] xref: EC:1.1.1.16 xref: KEGG_REACTION:R02928 xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN xref: RHEA:20685 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0047714 name: galactolipase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN] synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26] synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26] synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26] xref: EC:3.1.1.26 xref: MetaCyc:GALACTOLIPASE-RXN xref: RHEA:13189 is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047715 name: hypotaurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.6, RHEA:24008] synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6] xref: EC:2.7.3.6 xref: KEGG_REACTION:R03939 xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN xref: RHEA:24008 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047716 name: imidazole N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA." [EC:2.3.1.2, RHEA:15813] synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2] synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2] xref: EC:2.3.1.2 xref: KEGG_REACTION:R03621 xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN xref: RHEA:15813 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047717 name: imidazoleacetate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+)." [EC:1.14.13.5, RHEA:19425] synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5] synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5] synonym: "imidazoleacetic hydroxylase activity" EXACT [] synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5] xref: EC:1.14.13.5 xref: KEGG_REACTION:R04066 xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN xref: RHEA:19425 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047718 name: indanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112] xref: EC:1.1.1.112 xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047719 name: indole 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde." [EC:1.13.11.17, RHEA:11212] synonym: "IDO" RELATED [EC:1.13.11.17] synonym: "indole oxidase activity" EXACT [EC:1.13.11.17] synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17] synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] xref: EC:1.13.11.17 xref: KEGG_REACTION:R02338 xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN xref: RHEA:11212 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047720 name: indoleacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O." [EC:4.99.1.6, RHEA:23156] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6] synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] xref: EC:4.99.1.6 xref: KEGG_REACTION:R04093 xref: MetaCyc:RXN-1403 xref: RHEA:23156 is_a: GO:0016829 ! lyase activity [Term] id: GO:0047721 name: indoleacetate-lysine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate." [EC:6.3.2.20, RHEA:14857] synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20] synonym: "indoleacetate-lysine ligase activity" EXACT [] synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20] xref: EC:6.3.2.20 xref: KEGG_REACTION:R03095 xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN xref: RHEA:14857 is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity [Term] id: GO:0047722 name: indolelactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH." [EC:1.1.1.110, RHEA:20133] synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] synonym: "indole-3-lactate dehydrogenase activity" EXACT [] synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] xref: EC:1.1.1.110 xref: KEGG_REACTION:R01971 xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN xref: RHEA:20133 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047723 name: inosinate nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, RHEA:20469] synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12] xref: EC:3.2.2.12 xref: KEGG_REACTION:R01128 xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN xref: RHEA:20469 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0047724 name: inosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN] synonym: "inosinase activity" EXACT [EC:3.2.2.2] synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2] synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2] xref: EC:3.2.2.2 xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN xref: RHEA:16657 is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0047725 name: inulosucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN] synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9] xref: EC:2.4.1.9 xref: MetaCyc:INULOSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047726 name: iron-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.98.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN] synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.98.1] synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.98.1] xref: EC:1.9.98.1 xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN xref: RHEA:15617 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0047727 name: isobutyryl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA." [EC:5.4.99.13, RHEA:13141] synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13] synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13] synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13] xref: EC:5.4.99.13 xref: KEGG_REACTION:R01181 xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN xref: RHEA:13141 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0047728 name: carnitine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.108, RHEA:19265] synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108] xref: EC:1.1.1.108 xref: KEGG_REACTION:R02395 xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN xref: RHEA:19265 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047729 name: carnitine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2)." [EC:4.1.1.42, RHEA:21576] synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42] synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42] xref: EC:4.1.1.42 xref: KEGG_REACTION:R02398 xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN xref: RHEA:21576 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047730 name: carnosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN] synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11] synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11] synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11] xref: EC:6.3.2.11 xref: MetaCyc:CARNOSINE-SYNTHASE-RXN xref: Reactome:R-HSA-6786245 "CARNS1 transforms ATP, L-His, b-Ala to CARN" xref: RHEA:19297 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047731 name: catechol oxidase (dimerizing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN] synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14] xref: EC:1.1.3.14 xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN xref: RHEA:12809 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047732 name: CDP-abequose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, RHEA:21656] synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10] synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10] synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10] xref: EC:5.1.3.10 xref: KEGG_REACTION:R04266 xref: MetaCyc:RXN-9160 xref: RHEA:21656 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047733 name: CDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O." [EC:4.2.1.45, RHEA:17153] synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45] synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45] synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45] xref: EC:4.2.1.45 xref: KEGG_REACTION:R02426 xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN xref: RHEA:17153 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047734 name: CDP-glycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+)." [EC:3.6.1.16, RHEA:21692] synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDP-glycerol pyrophosphatase activity" EXACT [] synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] xref: EC:3.6.1.16 xref: KEGG_REACTION:R00855 xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN xref: RHEA:21692 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047735 name: cellobiose dehydrogenase (acceptor) activity namespace: molecular_function alt_id: GO:0047737 def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "CBOR activity" RELATED [EC:1.1.99.18] synonym: "CDH activity" RELATED [EC:1.1.99.18] synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18] synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18] synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18] synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] xref: EC:1.1.99.18 xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:23484 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047736 name: cellobiose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN] synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11] xref: EC:5.1.3.11 xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN xref: RHEA:23384 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047738 name: cellobiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN] synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20] xref: EC:2.4.1.20 xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN xref: RHEA:19493 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0047739 name: cephalosporin-C deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+)." [EC:3.1.1.41, RHEA:22596] synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41] synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41] xref: EC:3.1.1.41 xref: KEGG_REACTION:R03062 xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN xref: RHEA:22596 is_a: GO:0019213 ! deacetylase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047740 name: cephalosporin-C transaminase activity namespace: molecular_function def: "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C." [EC:2.6.1.74, RHEA:14553] synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74] synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74] xref: EC:2.6.1.74 xref: KEGG_REACTION:R03063 xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN xref: RHEA:14553 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047741 name: cetraxate benzylesterase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+)." [EC:3.1.1.70, RHEA:23460] synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70] xref: EC:3.1.1.70 xref: KEGG_REACTION:R03612 xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN xref: RHEA:23460 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047742 name: chenodeoxycholoyltaurine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN] synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74] xref: EC:3.5.1.74 xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN xref: RHEA:16309 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047743 name: chlordecone reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH." [EC:1.1.1.225, RHEA:14401] synonym: "CDR activity" RELATED [EC:1.1.1.225] synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225] xref: EC:1.1.1.225 xref: KEGG_REACTION:R03716 xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN xref: RHEA:14401 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047744 name: chloridazon-catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)." [EC:1.13.11.36, RHEA:20449] synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36] xref: EC:1.13.11.36 xref: KEGG_REACTION:R04602 xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN xref: RHEA:20449 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047745 name: chlorogenate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+)." [EC:3.1.1.42, RHEA:20689] synonym: "chlorogenase activity" EXACT [EC:3.1.1.42] synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42] xref: EC:3.1.1.42 xref: KEGG_REACTION:R02997 xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN xref: RHEA:20689 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047746 name: chlorophyllase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN] synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14] xref: EC:3.1.1.14 xref: MetaCyc:CHLOROPHYLLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047747 name: cholate-CoA ligase activity namespace: molecular_function alt_id: GO:0047477 def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT [] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "BAL activity" RELATED [EC:6.2.1.29] synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29] synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29] synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29] synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29] synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29] synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29] synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29] xref: EC:6.2.1.7 xref: MetaCyc:CHOLATE--COA-LIGASE-RXN is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047748 name: cholestanetetraol 26-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [] synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [] synonym: "TEHC-NAD oxidoreductase activity" EXACT [] xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN xref: RHEA:12395 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047749 name: cholestanetriol 26-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.15.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.15.15] synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.15.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.15.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.15.15] synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.15.15] synonym: "cholestanetriol 26-hydroxylase activity" EXACT [EC:1.14.15.15] synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.15.15] synonym: "CYP27A" RELATED [] synonym: "CYP27A1" RELATED [] synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.15.15] synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.15.15] synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.15.15] xref: EC:1.14.15.15 xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN xref: RHEA:14373 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047750 name: cholestenol delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN] synonym: "cholestenol D-isomerase activity" EXACT [] synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5] xref: EC:5.3.3.5 xref: MetaCyc:RXN66-25 xref: RHEA:15281 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0047751 name: cholestenone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH." [EC:1.3.1.22, RHEA:24552] synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22] synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "cholestenone 5a-reductase activity" EXACT [] synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22] synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22] synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22] xref: EC:1.3.1.22 xref: KEGG_REACTION:R02610 xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN xref: RHEA:24552 is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0047753 name: choline-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate." [EC:3.1.6.6, RHEA:20820] synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6] synonym: "choline-sulphatase activity" EXACT [] xref: EC:3.1.6.6 xref: KEGG_REACTION:R01028 xref: MetaCyc:CHOLINE-SULFATASE-RXN xref: RHEA:20820 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047754 name: choline sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+)." [EC:2.8.2.6, RHEA:21984] synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6] synonym: "choline sulphotransferase activity" EXACT [] xref: EC:2.8.2.6 xref: KEGG_REACTION:R01027 xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN xref: RHEA:21984 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047755 name: isocitrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate." [EC:5.1.2.6, RHEA:10820] synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6] xref: EC:5.1.2.6 xref: KEGG_REACTION:R02318 xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN xref: RHEA:10820 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0047756 name: chondroitin 4-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5] synonym: "chondroitin 4-sulphotransferase activity" EXACT [] xref: EC:2.8.2.5 xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-1971483 "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13" is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0047757 name: chondroitin-glucuronate 5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN] synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19] synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19] xref: EC:5.1.3.19 xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN xref: Reactome:R-HSA-2022052 "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)" xref: RHEA:21084 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047758 name: ATP:2-methylpropanoate phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+)." [EC:2.7.2.14, RHEA:24156] synonym: "ATP:2-methylpropanoate 1-phosphotransferase activity" EXACT [] synonym: "ATP:2-methylpropanoate kinase activity" EXACT [] synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" BROAD [EC:2.7.2.14, KEGG_REACTION:R04002] synonym: "ATP:isobutyrate 1-phosphotransferase activity" EXACT [] synonym: "branched-chain fatty acid kinase activity" BROAD [EC:2.7.2.14] synonym: "branched-chain-fatty-acid kinase activity" BROAD [EC:2.7.2.14] synonym: "isobutyrate kinase activity" BROAD [EC:2.7.2.14] xref: EC:2.7.2.14 xref: KEGG_REACTION:R04002 xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN xref: RHEA:24156 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047759 name: butanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN] synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57] xref: EC:1.2.1.57 xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047760 name: butyrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN] synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2] synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2] synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2] synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2] synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2] synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2] synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] xref: EC:6.2.1.2 xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN xref: Reactome:R-HSA-8875013 "ACSM3,ACSM6 ligate CoA to BUT" xref: RHEA:24336 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047761 name: butyrate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+)." [EC:2.7.2.7, RHEA:13585] synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7] xref: EC:2.7.2.7 xref: KEGG_REACTION:R01688 xref: MetaCyc:BUTYRATE-KINASE-RXN xref: RHEA:13585 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047762 name: caffeate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)." [EC:1.13.11.22, RHEA:22216] synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22] xref: EC:1.13.11.22 xref: KEGG_REACTION:R03365 xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN xref: RHEA:22216 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047763 name: caffeate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN] synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68] xref: EC:2.1.1.68 xref: MetaCyc:RXN-1104 xref: RHEA:20225 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0047764 name: obsolete caldesmon kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators] comment: This term was made obsolete because it represents a specific gene product. xref: MetaCyc:2.7.11.17-RXN is_obsolete: true [Term] id: GO:0047765 name: caldesmon-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN] synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55] synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55] synonym: "SMP-I" RELATED [EC:3.1.3.55] xref: EC:3.1.3.55 xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047766 name: carbamoyl-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate." [EC:4.3.1.13, RHEA:15445] synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13] synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13] xref: EC:4.3.1.13 xref: KEGG_REACTION:R00213 xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN xref: RHEA:15445 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047768 name: carboxy-cis,cis-muconate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, RHEA:14977] synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5] synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5] synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5] xref: EC:5.5.1.5 xref: KEGG_REACTION:R03308 xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN xref: RHEA:14977 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047769 name: arogenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN] synonym: "carboxycyclohexadienyl dehydratase activity" EXACT [] synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91] synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91] xref: EC:4.2.1.91 xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN xref: RHEA:12536 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047770 name: carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN] synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6] synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6] xref: EC:1.2.99.6 xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047771 name: carboxymethylhydantoinase activity namespace: molecular_function def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.4, RHEA:12028] synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4] synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4] xref: EC:3.5.2.4 xref: KEGG_REACTION:R02284 xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN xref: RHEA:12028 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047772 name: carboxymethyloxysuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate." [EC:4.2.99.12, RHEA:12336] synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12] synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12] xref: EC:4.2.99.12 xref: KEGG_REACTION:R01336 xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN xref: RHEA:12336 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0047773 name: carnitinamidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+)." [EC:3.5.1.73, RHEA:17537] synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73] synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73] xref: EC:3.5.1.73 xref: KEGG_REACTION:R01922 xref: MetaCyc:CARNITINAMIDASE-RXN xref: RHEA:17537 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047774 name: cis-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN] synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37] synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37] synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37] synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37] xref: EC:1.3.1.37 xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047775 name: citramalate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN] synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11] xref: EC:2.8.3.11 xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN xref: RHEA:17621 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0047776 name: citramalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: S-citramalate = acetate + pyruvate." [EC:4.1.3.22, RHEA:15545] synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22] synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22] synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22] synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22] xref: EC:4.1.3.22 xref: KEGG_REACTION:R00325 xref: MetaCyc:CITRAMALATE-LYASE-RXN xref: RHEA:15545 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047777 name: (3S)-citramalyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, RHEA:22612] synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25] synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25] synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25] synonym: "citramalyl-CoA lyase activity" BROAD [] xref: EC:4.1.3.25 xref: KEGG_REACTION:R00237 xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN xref: RHEA:22612 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0047778 name: [citrate-(pro-3S)-lyase] thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN] synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT [] synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16] xref: EC:3.1.2.16 xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0047779 name: citrate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate." [EC:6.2.1.18, RHEA:21472] synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18] synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18] synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18] xref: EC:6.2.1.18 xref: KEGG_REACTION:R01322 xref: MetaCyc:CITRATE--COA-LIGASE-RXN xref: RHEA:21472 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047780 name: citrate dehydratase activity namespace: molecular_function alt_id: GO:0052632 def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.3] comment: This term is also a sub-reaction of 'aconitate hydratase activity ; GO:0003994 (EC:4.2.1.3)'. synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase (cis-aconitate-forming) activity" EXACT [] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] xref: EC:4.2.1.3 xref: KEGG_REACTION:R01325 xref: MetaCyc:ACONITATEDEHYDR-RXN xref: MetaCyc:CITRATE-DEHYDRATASE-RXN xref: RHEA:10228 is_a: GO:0016836 ! hydro-lyase activity relationship: has_part GO:0003994 ! aconitate hydratase activity [Term] id: GO:0047781 name: citrullinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN] synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20] synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] xref: EC:3.5.1.20 xref: MetaCyc:CITRULLINASE-RXN xref: RHEA:11940 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047782 name: coniferin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN] synonym: "coniferin b-glucosidase activity" EXACT [] synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126] synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126] xref: EC:3.2.1.126 xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN xref: RHEA:12252 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0047783 name: corticosterone 18-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN] synonym: "corticosterone 18-hydroxylase activity" EXACT [] synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5] xref: EC:1.14.15.5 xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047784 name: cortisol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, RHEA:17073] synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27] synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27] xref: EC:2.3.1.27 xref: KEGG_REACTION:R02837 xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN xref: RHEA:17073 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0047785 name: cortisol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+)." [EC:2.8.2.18, RHEA:11884] synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "cortisol sulphotransferase activity" EXACT [] synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18] synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18] xref: EC:2.8.2.18 xref: KEGG_REACTION:R02839 xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN xref: RHEA:11884 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047786 name: cortisone alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH." [EC:1.3.1.4, RHEA:17981] synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4] synonym: "cortisone a-reductase activity" EXACT [] synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4] synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4] synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4] xref: EC:1.3.1.4 xref: KEGG_REACTION:R02892 xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN xref: RHEA:17981 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047787 name: delta4-3-oxosteroid 5beta-reductase activity namespace: molecular_function alt_id: GO:0047752 def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN] synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23] synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23] synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cholestenone 5-beta-reductase activity" EXACT [] synonym: "cholestenone 5b-reductase activity" EXACT [] synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone b-reductase activity" EXACT [] synonym: "cortisone beta-reductase activity" EXACT [] synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-3-oxosteroid 5-beta-reductase activity" EXACT [] synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23] synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23] xref: EC:1.3.1.3 xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN is_a: GO:0035671 ! enone reductase activity [Term] id: GO:0047788 name: 2-coumarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH." [EC:1.3.1.11, RHEA:21444] synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11] synonym: "coumarate reductase activity" EXACT [] synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11] xref: EC:1.3.1.11 xref: KEGG_REACTION:R03709 xref: MetaCyc:COUMARATE-REDUCTASE-RXN xref: RHEA:21444 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047789 name: creatininase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H(2)O = creatine." [EC:3.5.2.10, RHEA:14533] synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10] synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10] xref: EC:3.5.2.10 xref: KEGG_REACTION:R01884 xref: MetaCyc:CREATININASE-RXN xref: RHEA:14533 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0047790 name: creatinine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN] synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21] synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21] synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21] xref: EC:3.5.4.21 xref: MetaCyc:CREATININE-DEAMINASE-RXN xref: RHEA:12681 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047791 name: cucurbitacin delta23-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN] synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] synonym: "cucurbitacin D23-reductase activity" EXACT [] synonym: "cucurbitacin delta(23) reductase activity" EXACT [] synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] xref: EC:1.3.1.5 xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047792 name: cyanohydrin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cyanohydrin b-glucosyltransferase activity" EXACT [] synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85] synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85] xref: EC:2.4.1.85 xref: RHEA:12853 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047793 name: cycloeucalenol cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, RHEA:22800] synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9] synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT [] xref: EC:5.5.1.9 xref: KEGG_REACTION:R03775 xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN xref: RHEA:22800 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047794 name: cyclohexadienyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN] synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43] synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43] synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43] xref: EC:1.3.1.43 xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN xref: RHEA:12256 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047795 name: cyclohexane-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN] synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174] xref: EC:1.1.1.174 xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN xref: RHEA:18141 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047796 name: cyclohexane-1,3-dione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+)." [EC:3.7.1.10, RHEA:16473] synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10] synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10] xref: EC:3.7.1.10 xref: KEGG_REACTION:R03211 xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN xref: RHEA:16473 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0047797 name: cyclohexanone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone." [EC:1.3.99.14, RHEA:21780] synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14] synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14] xref: EC:1.3.99.14 xref: KEGG_REACTION:R02234 xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN xref: RHEA:21780 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0047798 name: cyclomaltodextrinase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN] synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54] synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54] xref: EC:3.2.1.54 xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047799 name: cyclopentanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+)." [EC:1.14.13.16, RHEA:15737] synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16] synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16] xref: EC:1.14.13.16 xref: KEGG_REACTION:R02554 xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN xref: RHEA:15737 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047800 name: cysteamine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine." [EC:1.13.11.19, RHEA:14409] synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19] synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] synonym: "persulfurase activity" RELATED [EC:1.13.11.19] xref: EC:1.13.11.19 xref: KEGG_REACTION:R02467 xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN xref: Reactome:R-HSA-6814153 "ADO oxidises 2AET to HTAU" xref: RHEA:14409 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047801 name: L-cysteine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN] synonym: "CGT" RELATED [EC:2.6.1.3] synonym: "cysteine aminotransferase activity" BROAD [] synonym: "cysteine transaminase activity" BROAD [EC:2.6.1.3] synonym: "L-cysteine aminotransferase activity" BROAD [EC:2.6.1.3] xref: EC:2.6.1.3 xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-9012597 "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu" xref: RHEA:17441 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047802 name: cysteine-conjugate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate." [EC:2.6.1.75, RHEA:13485] synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75] synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75] synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75] xref: EC:2.6.1.75 xref: KEGG_REACTION:R04338 xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN xref: RHEA:13485 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047803 name: cysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN] synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10] synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10] xref: EC:4.4.1.10 xref: MetaCyc:CYSTEINE-LYASE-RXN xref: RHEA:20916 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047804 name: cysteine-S-conjugate beta-lyase activity namespace: molecular_function def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN] synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "cysteine-S-conjugate b-lyase activity" EXACT [] synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13] synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13] xref: EC:4.4.1.13 xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047805 name: cytidylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+)." [EC:4.6.1.6, RHEA:14737] synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6] synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6] synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6] synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6] xref: EC:4.6.1.6 xref: KEGG_REACTION:R00574 xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN xref: RHEA:14737 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity relationship: part_of GO:0009190 ! cyclic nucleotide biosynthetic process [Term] id: GO:0047806 name: cytochrome-c3 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN] synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1] synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1] synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1] xref: EC:1.12.2.1 xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN xref: UM-BBD_enzymeID:e0481 is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor [Term] id: GO:0047807 name: cytokinin 7-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT [] synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] xref: EC:2.4.1.118 xref: KEGG_REACTION:R04071 xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:23272 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047808 name: D(-)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.81, RHEA:18289] synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81] synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81] synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81] xref: EC:4.2.1.81 xref: KEGG_REACTION:R00340 xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN xref: RHEA:18289 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047809 name: D-2-hydroxy-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate." [EC:1.1.99.6, RHEA:15089] synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6] synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6] xref: EC:1.1.99.6 xref: KEGG_REACTION:R00297 xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN xref: RHEA:15089 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047810 name: D-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN] synonym: "D-alanine aminotransferase activity" EXACT [] synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21] synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21] synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21] synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21] synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21] xref: EC:2.6.1.21 xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN xref: RHEA:15869 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047811 name: D-alanine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+)." [EC:2.3.2.14, RHEA:23556] synonym: "D-alanine g-glutamyltransferase activity" EXACT [] synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14] xref: EC:2.3.2.14 xref: KEGG_REACTION:R01149 xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN xref: RHEA:23556 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047812 name: D-amino-acid N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36] synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36] xref: EC:2.3.1.36 xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN xref: RHEA:20704 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047813 name: D-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN] xref: EC:1.1.1.11 xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN xref: RHEA:17921 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047814 name: D-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP." [EC:2.7.1.54, RHEA:24588] synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54] synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54] xref: EC:2.7.1.54 xref: KEGG_REACTION:R01573 xref: MetaCyc:D-ARABINOKINASE-RXN xref: RHEA:24588 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047815 name: D-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+)." [EC:3.1.1.30, RHEA:23108] synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30] xref: EC:3.1.1.30 xref: KEGG_REACTION:R02714 xref: MetaCyc:D-ARABINONOLACTONASE-RXN xref: RHEA:23108 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047816 name: D-arabinose 1-dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116] synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116] synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116] xref: EC:1.1.1.116 xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN xref: RHEA:20457 is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity [Term] id: GO:0047817 name: D-arginase activity namespace: molecular_function def: "Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea." [EC:3.5.3.10, RHEA:12901] synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10] xref: EC:3.5.3.10 xref: KEGG_REACTION:R02458 xref: MetaCyc:D-ARGINASE-RXN xref: RHEA:12901 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047818 name: D-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O." [EC:4.2.1.67, RHEA:12949] synonym: "D-fuconate hydratase activity" EXACT [] synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67] synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67] xref: EC:4.2.1.67 xref: KEGG_REACTION:R03671 xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN xref: RHEA:12949 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047819 name: D-glutamate(D-aspartate) oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN] comment: For the individual reactions, see instead 'D-glutamate oxidase activity ;GO:0047821' and 'D-aspartate oxidase activity ; GO:0008445'. synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15] synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15] synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15] xref: EC:1.4.3.15 xref: MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN is_a: GO:0003884 ! D-amino-acid oxidase activity [Term] id: GO:0047820 name: D-glutamate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O." [EC:4.2.1.48, RHEA:22360] synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48] synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48] xref: EC:4.2.1.48 xref: KEGG_REACTION:R01583 xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN xref: RHEA:22360 is_a: GO:0009975 ! cyclase activity is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047821 name: D-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN] synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7] synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7] synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7] xref: EC:1.4.3.7 xref: KEGG_REACTION:R00279 xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN xref: RHEA:10028 is_a: GO:0003884 ! D-amino-acid oxidase activity [Term] id: GO:0047822 name: hypotaurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine." [EC:1.8.1.3, RHEA:17385] synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3] xref: EC:1.8.1.3 xref: KEGG_REACTION:R01681 xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-1655453 "HTAUDH oxidises HTAU to TAU" xref: RHEA:17385 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0047823 name: D-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN] synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1] xref: EC:2.3.2.1 xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0047824 name: D-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN] xref: EC:1.1.1.15 xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN xref: RHEA:12725 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor is_a: GO:0031320 ! hexitol dehydrogenase activity [Term] id: GO:0047825 name: D-lactate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate." [EC:3.1.6.17, RHEA:20337] synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17] synonym: "D-lactate-2-sulphatase activity" EXACT [] xref: EC:3.1.6.17 xref: KEGG_REACTION:R01448 xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN xref: RHEA:20337 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047826 name: D-lysine 5,6-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, RHEA:18241] synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4] synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4] xref: EC:5.4.3.4 xref: KEGG_REACTION:R02852 xref: MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN xref: RHEA:18241 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047827 name: D-lysopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate." [EC:1.5.1.16, RHEA:17625] synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16] synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] xref: EC:1.5.1.16 xref: KEGG_REACTION:R00452 xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN xref: RHEA:17625 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047828 name: D-lyxose ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, RHEA:14201] synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15] synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15] xref: EC:5.3.1.15 xref: KEGG_REACTION:R01898 xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN xref: RHEA:14201 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0047829 name: D-nopaline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN] synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19] synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19] synonym: "NOS activity" EXACT [EC:1.5.1.19] xref: EC:1.5.1.19 xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN xref: RHEA:19637 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047830 name: D-octopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN] synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11] synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11] synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11] synonym: "ODH activity" EXACT [EC:1.5.1.11] xref: EC:1.5.1.11 xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN xref: RHEA:16285 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047831 name: D-ornithine 4,5-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, RHEA:14893] synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5] synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5] xref: EC:5.4.3.5 xref: KEGG_REACTION:R02461 xref: MetaCyc:ORNMUTST-RXN xref: RHEA:14893 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0047832 name: D-pinitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH." [EC:1.1.1.142, RHEA:20437] synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] xref: EC:1.1.1.142 xref: KEGG_REACTION:R03498 xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN xref: RHEA:20437 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047833 name: D-sorbitol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] synonym: "D-sorbitol dehydrogenase activity" EXACT [] synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21] synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21] xref: EC:1.1.99.21 xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN xref: RHEA:21320 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047834 name: D-threo-aldose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN] synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122] synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122] synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122] xref: EC:1.1.1.122 xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047835 name: D-tryptophan N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.34, RHEA:10060] synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34] synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34] xref: EC:2.3.1.34 xref: KEGG_REACTION:R02481 xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN xref: RHEA:10060 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047836 name: D-tryptophan N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.112, RHEA:23320] synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112] xref: EC:2.3.1.112 xref: KEGG_REACTION:R02482 xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN xref: RHEA:23320 is_a: GO:0050735 ! N-malonyltransferase activity [Term] id: GO:0047837 name: D-xylose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH." [EC:1.1.1.179, RHEA:22000] synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179] synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179] xref: EC:1.1.1.179 xref: KEGG_REACTION:R01430 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:22000 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047838 name: D-xylose 1-dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN] synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175] synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175] synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] xref: EC:1.1.1.175 xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN xref: RHEA:13861 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047839 name: dATP(dGTP)-DNA purinetransferase activity namespace: molecular_function def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN] synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT [] synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1] xref: EC:2.6.99.1 xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0047840 name: dCTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN] synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12] synonym: "dCTP pyrophosphatase activity" EXACT [] synonym: "dCTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12] synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12] xref: EC:3.6.1.12 xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN xref: Reactome:R-HSA-6786257 "DCTPP1 hydrolyses 5idCTP" xref: RHEA:22636 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0047841 name: dehydrogluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.13, RHEA:10788] synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13] synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13] synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13] synonym: "dehydogluconokinase activity" EXACT [] synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13] synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13] xref: EC:2.7.1.13 xref: KEGG_REACTION:R02658 xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN xref: RHEA:10788 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047842 name: dehydro-L-gulonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2)." [EC:4.1.1.34, RHEA:11084] synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34] synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34] synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] xref: EC:4.1.1.34 xref: KEGG_REACTION:R01905 xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN xref: Reactome:R-HSA-5662473 "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose" xref: RHEA:11084 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047843 name: dehydrogluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)." [EC:1.1.99.4, RHEA:12368] synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4] synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] xref: EC:1.1.99.4 xref: KEGG_REACTION:R07153 xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN xref: RHEA:12368 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047844 name: deoxycytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN] synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14] xref: EC:3.5.4.14 xref: MetaCyc:CYTIDEAM-RXN xref: RHEA:13433 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047845 name: deoxylimonate A-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+)." [EC:3.1.1.46, RHEA:14997] synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46] xref: EC:3.1.1.46 xref: KEGG_REACTION:R03803 xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN xref: RHEA:14997 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047846 name: deoxynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN] synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34] synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34] synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34] xref: EC:3.1.3.34 xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047847 name: deoxyuridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN] synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] xref: EC:2.4.2.23 xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN xref: RHEA:22824 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047848 name: dephospho-[reductase kinase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN] synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3] synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3] synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3] synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "reductase kinase activity" BROAD [EC:2.7.11.3] synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3] synonym: "STK30" RELATED [EC:2.7.11.3] xref: EC:2.7.11.3 xref: MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0047849 name: dextransucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN] synonym: "CEP" RELATED [EC:2.4.1.5] synonym: "SGE" RELATED [EC:2.4.1.5] synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5] synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5] xref: EC:2.4.1.5 xref: MetaCyc:DEXTRANSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0047850 name: diaminopimelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+)." [EC:1.4.1.16, RHEA:13561] synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16] synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16] synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] xref: EC:1.4.1.16 xref: KEGG_REACTION:R02755 xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN xref: RHEA:13561 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047851 name: dicarboxylate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN] synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23] synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23] xref: EC:6.2.1.23 xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047852 name: diferric-transferrin reductase activity namespace: molecular_function def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN] synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2] xref: EC:1.16.1.2 xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0047853 name: difructose-anhydride synthase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN] synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134] synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134] xref: EC:3.2.1.134 xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN xref: RHEA:15041 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047854 name: diguanidinobutanase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea." [EC:3.5.3.20, RHEA:13597] synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20] xref: EC:3.5.3.20 xref: KEGG_REACTION:R01418 xref: MetaCyc:DIGUANIDINOBUTANASE-RXN xref: RHEA:13597 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047855 name: dihydrobunolol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH." [EC:1.1.1.160, RHEA:15925] synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160] synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160] xref: EC:1.1.1.160 xref: KEGG_REACTION:R04623 xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN xref: RHEA:15925 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047856 name: dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+)." [EC:3.1.1.35, RHEA:10360] synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35] synonym: "dihydrocoumarin lipase activity" EXACT [] xref: EC:3.1.1.35 xref: KEGG_REACTION:R03692 xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN xref: RHEA:10360 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047857 name: dihydrouracil oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil." [EC:1.3.3.7, RHEA:12384] synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7] xref: EC:1.3.3.7 xref: KEGG_REACTION:R00975 xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN xref: RHEA:12384 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0047858 name: dihydroxyfumarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.54, RHEA:13845] synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54] synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54] xref: EC:4.1.1.54 xref: KEGG_REACTION:R03127 xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN xref: RHEA:13845 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047859 name: obsolete dihydroxyphenylalanine ammonia-lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN] comment: This term was made obsolete because the corresponding EC reaction has been deleted from the EC. synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" EXACT [EC:4.3.1.11] synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.11] synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" EXACT [EC:4.3.1.11] synonym: "dihydroxyphenylalanine ammonia-lyase activity" EXACT [] xref: EC:4.3.1.11 is_obsolete: true [Term] id: GO:0047860 name: diiodophenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH." [EC:1.1.1.96, RHEA:20293] synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96] synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96] synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96] synonym: "KAR" RELATED [EC:1.1.1.96] xref: EC:1.1.1.96 xref: KEGG_REACTION:R03431 xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN xref: RHEA:20293 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047861 name: diiodotyrosine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate." [EC:2.6.1.24, RHEA:19781] synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "diiodotyrosine aminotransferase activity" EXACT [] synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24] synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24] xref: EC:2.6.1.24 xref: KEGG_REACTION:R03207 xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN xref: RHEA:19781 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047862 name: diisopropyl-fluorophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride." [EC:3.1.8.2, RHEA:24100] synonym: "DFPase activity" EXACT [EC:3.1.8.2] synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2] synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2] synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2] synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2] synonym: "OPAA activity" EXACT [EC:3.1.8.2] synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2] synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2] synonym: "somanase activity" EXACT [EC:3.1.8.2] synonym: "tabunase activity" EXACT [EC:3.1.8.2] xref: EC:3.1.8.2 xref: KEGG_REACTION:R01533 xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN xref: RHEA:24100 is_a: GO:0016795 ! phosphoric triester hydrolase activity [Term] id: GO:0047863 name: dimethylallylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, RHEA:11328] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28] synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28] xref: EC:2.5.1.28 xref: KEGG_REACTION:R01659 xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN xref: RHEA:11328 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0047864 name: dimethylaniline-N-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, RHEA:19321] synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24] synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24] synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24] xref: EC:4.1.2.24 xref: KEGG_REACTION:R03345 xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN xref: RHEA:19321 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047865 name: dimethylglycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:22499] comment: Note that this was EC:1.5.99.2. synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.8.4] synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.8.4] synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.8.4] xref: EC:1.5.8.4 xref: KEGG_REACTION:R01565 xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN xref: Reactome:R-HSA-6797653 "DMGDH:FAD oxidatively demethylates DMGLY to SARC" xref: RHEA:22499 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0047866 name: dimethylglycine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine." [EC:1.5.3.10, RHEA:17077] synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10] xref: EC:1.5.3.10 xref: KEGG_REACTION:R01564 xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN xref: RHEA:17077 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0047867 name: dimethylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH." [EC:1.1.1.84, RHEA:13321] synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84] synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84] xref: EC:1.1.1.84 xref: KEGG_REACTION:R01211 xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN xref: RHEA:13321 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047868 name: dimethylmaleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O." [EC:4.2.1.85, RHEA:20253] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85] synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85] xref: EC:4.2.1.85 xref: KEGG_REACTION:R03069 xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN xref: RHEA:20253 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047869 name: dimethylpropiothetin dethiomethylase activity namespace: molecular_function def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)." [EC:4.4.1.3, RHEA:19965] synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3] synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3] xref: EC:4.4.1.3 xref: KEGG_REACTION:R02574 xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN xref: RHEA:19965 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047870 name: discadenine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+)." [EC:2.5.1.24, RHEA:19581] synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24] synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24] xref: EC:2.5.1.24 xref: KEGG_REACTION:R03726 xref: MetaCyc:DISCADENINE-SYNTHASE-RXN xref: RHEA:19581 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0047871 name: disulfoglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate." [EC:3.1.6.11, RHEA:15517] synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "disulphoglucosamine-6-sulphatase activity" EXACT [] synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11] synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11] xref: EC:3.1.6.11 xref: KEGG_REACTION:R03216 xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN xref: RHEA:15517 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047872 name: dolichol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123] synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123] xref: EC:2.3.1.123 xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047873 name: dolichyl-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN] synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51] synonym: "Dol-P-P phosphohydrolase activity" EXACT [] synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "dolichyl pyrophosphate phosphatase activity" EXACT [] synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51] synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51] xref: EC:3.1.3.51 xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN xref: RHEA:13797 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047874 name: dolichyldiphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN] synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43] synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] xref: EC:3.6.1.43 xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN xref: Reactome:R-HSA-446200 "DOLPP1 dephosphorylates DOLDP to DOLP" xref: RHEA:14385 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0047875 name: ecdysone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2)." [EC:1.1.3.16, RHEA:11796] synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16] synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16] xref: EC:1.1.3.16 xref: KEGG_REACTION:R02373 xref: MetaCyc:ECDYSONE-OXIDASE-RXN xref: RHEA:11796 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047876 name: endoglycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN] synonym: "EGCase activity" EXACT [EC:3.2.1.123] synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123] synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123] synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123] synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123] xref: EC:3.2.1.123 xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047877 name: ephedrine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH." [EC:1.5.1.18, RHEA:16289] synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18] xref: EC:1.5.1.18 xref: KEGG_REACTION:R03614 xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN xref: RHEA:16289 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0047878 name: erythritol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.27, RHEA:20708] synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27] synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27] xref: EC:2.7.1.27 xref: KEGG_REACTION:R02430 xref: MetaCyc:ERYTHRITOL-KINASE-RXN xref: RHEA:20708 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047879 name: erythronolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN] synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94] synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94] xref: EC:2.3.1.94 xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN xref: RHEA:23068 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047880 name: erythrulose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH." [EC:1.1.1.162, RHEA:18005] synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162] synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162] xref: EC:1.1.1.162 xref: KEGG_REACTION:R08573 xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN xref: RHEA:18005 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047881 name: estradiol 17-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN] synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17a-dehydrogenase activity" EXACT [] synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148] synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148] xref: EC:1.1.1.148 xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047882 name: estradiol 6-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O." [EC:1.14.99.11, RHEA:19137] synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6b-hydroxylase activity" EXACT [] synonym: "estradiol 6b-monooxygenase activity" EXACT [] synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11] synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11] synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11] xref: EC:1.14.99.11 xref: KEGG_REACTION:R03086 xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN xref: RHEA:19137 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0047883 name: ethanolamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN] synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8] xref: EC:1.4.3.8 xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN xref: RHEA:18581 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0047884 name: FAD diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN] synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18] synonym: "FAD pyrophosphatase activity" EXACT [] synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb] synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] xref: EC:3.6.1.18 xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN xref: RHEA:13889 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0047885 name: farnesol 2-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, RHEA:13401] synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9] synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9] xref: EC:5.2.1.9 xref: KEGG_REACTION:R03265 xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN xref: RHEA:13401 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047886 name: farnesol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14697] synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216] synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216] synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216] xref: EC:1.1.1.216 xref: KEGG_REACTION:R03264 xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN xref: RHEA:14697 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047887 name: farnesyl diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP." [EC:2.7.4.18, RHEA:21544] synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18] synonym: "farnesyl-diphosphate kinase activity" EXACT [] xref: EC:2.7.4.18 xref: KEGG_REACTION:R02303 xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN xref: RHEA:21544 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0047888 name: fatty acid peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal." [EC:1.11.1.3, RHEA:23960] synonym: "fatty-acid peroxidase activity" EXACT [] synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3] synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3] xref: EC:1.11.1.3 xref: KEGG_REACTION:R01703 xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN xref: RHEA:23960 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0047889 name: ferredoxin-nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN] synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2] synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2] synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2] xref: EC:1.7.7.2 xref: MetaCyc:1.7.7.2-RXN is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] id: GO:0047890 name: flavanone 4-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN] synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234] synonym: "flavonone 4-reductase activity" EXACT [] xref: EC:1.1.1.234 xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN xref: RHEA:11228 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047891 name: flavone 7-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81] synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81] xref: EC:2.4.1.81 xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:19577 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047892 name: flavone apiosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN] synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] xref: EC:2.4.2.25 xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047893 name: flavonol 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN] synonym: "GTI" RELATED [EC:2.4.1.91] synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] xref: EC:2.4.1.91 xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN xref: RHEA:22300 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047894 name: flavonol 3-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13453] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25] synonym: "flavonol 3-sulphotransferase activity" EXACT [] xref: EC:2.8.2.25 xref: KEGG_REACTION:R02159 xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN xref: RHEA:13453 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047895 name: formaldehyde dismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.98.1, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN] synonym: "aldehyde dismutase activity" EXACT [EC:1.2.98.1] synonym: "cannizzanase activity" EXACT [EC:1.2.98.1] synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.98.1] synonym: "nicotinoprotein aldehyde dismutase" EXACT [EC:1.2.98.1] xref: EC:1.2.98.1 xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN xref: RHEA:19221 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0047896 name: formaldehyde transketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN] synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3] synonym: "DHAS activity" EXACT [EC:2.2.1.3] synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3] synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3] xref: EC:2.2.1.3 xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN xref: RHEA:24264 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0047897 name: formate-dihydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate." [EC:6.3.4.17, RHEA:24328] synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17] synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17] synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17] xref: EC:6.3.4.17 xref: KEGG_REACTION:R02238 xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN xref: RHEA:24328 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047898 name: formate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1] synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1] xref: EC:1.2.2.1 xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0047899 name: formate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH." [EC:1.17.1.10, RHEA:12000] synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.17.1.10] synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.17.1.10] xref: EC:1.17.1.10 xref: KEGG_REACTION:R00134 xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:12000 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047900 name: formate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+)." [EC:2.7.2.6, RHEA:16009] synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6] xref: EC:2.7.2.6 xref: KEGG_REACTION:R00518 xref: MetaCyc:FORMATE-KINASE-RXN xref: RHEA:16009 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047901 name: formyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+)." [EC:3.1.2.10, RHEA:19741] synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10] xref: EC:3.1.2.10 xref: KEGG_REACTION:R00521 xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN xref: RHEA:19741 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047902 name: formylaspartate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN] synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8] synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8] xref: EC:3.5.1.8 xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN xref: RHEA:22040 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047903 name: fructose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN] synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124] synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124] synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124] synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124] xref: EC:1.1.1.124 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN xref: RHEA:14069 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047904 name: fructose 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.11, RHEA:22304] synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11] synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11] xref: EC:1.1.99.11 xref: KEGG_REACTION:R00873 xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN xref: RHEA:22304 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047905 name: fructose-6-phosphate phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN] synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22] synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22] xref: EC:4.1.2.22 xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN xref: RHEA:12196 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047906 name: fucosterol-epoxide lyase activity namespace: molecular_function def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol." [EC:4.1.2.33, RHEA:10884] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33] synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33] xref: EC:4.1.2.33 xref: KEGG_REACTION:R03723 xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN xref: RHEA:10884 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0047907 name: furylfuramide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, RHEA:21848] synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6] xref: EC:5.2.1.6 xref: KEGG_REACTION:R04538 xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN xref: RHEA:21848 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0047908 name: fusarinine-C ornithinesterase activity namespace: molecular_function def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN] synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48] xref: EC:3.1.1.48 xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047909 name: galactolipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN] synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134] synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134] xref: EC:2.3.1.134 xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0047910 name: galactose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN] synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120] synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120] xref: EC:1.1.1.120 xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:18625 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047911 name: galacturan 1,4-alpha-galacturonidase activity namespace: molecular_function def: "Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN] synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67] synonym: "exo-D-galacturonase activity" EXACT [] synonym: "exo-polygalacturonase activity" EXACT [] synonym: "exopoly-D-galacturonase activity" EXACT [] synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67] synonym: "galacturan alpha-1,4-galacturonidase activity" EXACT [] synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67] synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67] xref: EC:3.2.1.67 xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047912 name: galacturonokinase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+)." [EC:2.7.1.44, RHEA:12965] synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44] synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44] xref: EC:2.7.1.44 xref: KEGG_REACTION:R01980 xref: MetaCyc:GALACTURONOKINASE-RXN xref: RHEA:12965 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047913 name: gallate 1-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." [EC:2.4.1.136, RHEA:15249] synonym: "gallate 1-b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136] synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136] xref: EC:2.4.1.136 xref: KEGG_REACTION:R03297 xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:15249 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047914 name: gamma-glutamylhistamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN] synonym: "g-glutamylhistamine synthase activity" EXACT [] synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18] synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18] synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18] xref: EC:6.3.2.18 xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047915 name: ganglioside galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62] synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] xref: EC:2.4.1.62 xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN xref: RHEA:16773 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0047916 name: GDP-6-deoxy-D-talose 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN] synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135] synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135] xref: EC:1.1.1.135 xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047917 name: GDP-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+)." [EC:3.2.1.42, RHEA:15049] synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42] xref: EC:3.2.1.42 xref: KEGG_REACTION:R00337 xref: MetaCyc:GDP-GLUCOSIDASE-RXN xref: RHEA:15049 is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0047918 name: GDP-mannose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18] synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18] synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18] synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18] xref: EC:5.1.3.18 xref: MetaCyc:RXN-1882 xref: RHEA:11144 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047919 name: GDP-mannose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH." [EC:1.1.1.132, RHEA:21728] synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132] synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132] synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132] xref: EC:1.1.1.132 xref: KEGG_REACTION:R00880 xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN xref: RHEA:21728 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047920 name: geissoschizine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH." [EC:1.3.1.36, RHEA:11376] synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36] xref: EC:1.3.1.36 xref: KEGG_REACTION:R03860 xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN xref: RHEA:11376 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0047921 name: aminoglycoside 2'-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.59, RHEA:24516] synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59] synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW [] synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59] xref: EC:2.3.1.59 xref: KEGG_REACTION:R03056 xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN xref: RHEA:24516 is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity [Term] id: GO:0047922 name: gentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+)." [EC:1.13.11.4, RHEA:18237] synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4] synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4] synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4] xref: EC:1.13.11.4 xref: KEGG_REACTION:R02656 xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN xref: RHEA:18237 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0047923 name: gentisate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone." [EC:4.1.1.62, RHEA:21312] synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62] synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62] synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62] xref: EC:4.1.1.62 xref: KEGG_REACTION:R02489 xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN xref: RHEA:21312 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047924 name: geraniol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN] synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183] xref: EC:1.1.1.183 xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN xref: RHEA:14521 xref: UM-BBD_reactionID:r1163 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047925 name: geranoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.5, RHEA:17701] synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5] synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5] synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5] xref: EC:6.4.1.5 xref: KEGG_REACTION:R03494 xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN xref: RHEA:17701 xref: UM-BBD_reactionID:r1166 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0047926 name: geranyl-diphosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate." [EC:5.5.1.8, RHEA:18209] synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8] synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8] synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8] synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8] xref: EC:5.5.1.8 xref: KEGG_REACTION:R02007 xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN xref: RHEA:18209 is_a: GO:0009975 ! cyclase activity is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0047927 name: gibberellin-44 dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN] synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] xref: EC:1.14.11.12 xref: MetaCyc:RXN1F-168 xref: RHEA:16033 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0047928 name: gibberellin beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "gibberellin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176] synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176] xref: EC:2.4.1.176 xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:20025 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0047929 name: gluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.39, RHEA:21612] synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39] synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39] xref: EC:4.2.1.39 xref: KEGG_REACTION:R01538 xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN xref: RHEA:21612 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047930 name: glucosaminate ammonia-lyase activity namespace: molecular_function alt_id: GO:0050443 def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN] comment: Note that this function was EC:4.3.1.21. synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9] synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9] synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT [] synonym: "aminodeoxygluconate dehydratase activity" EXACT [] synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9] synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9] synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9] xref: EC:4.3.1.9 xref: MetaCyc:4.3.1.21-RXN xref: RHEA:12488 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0047931 name: glucosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN] synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8] synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8] synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8] xref: EC:2.7.1.8 xref: MetaCyc:GLUCOSAMINE-KINASE-RXN xref: RHEA:10948 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047932 name: glucosamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)." [EC:2.3.1.3, RHEA:21332] synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3] synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3] xref: EC:2.3.1.3 xref: KEGG_REACTION:R01204 xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:21332 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047933 name: glucose-1,6-bisphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+)." [EC:2.7.1.106, RHEA:16769] synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106] synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106] xref: EC:2.7.1.106 xref: KEGG_REACTION:R01660 xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN xref: Reactome:R-HSA-8955760 "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP" xref: RHEA:16769 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047934 name: glucose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN] synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118] synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118] xref: EC:1.1.1.118 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN xref: RHEA:14293 is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)] activity [Term] id: GO:0047935 name: glucose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN] synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119] synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] xref: EC:1.1.1.119 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:14405 is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)] activity [Term] id: GO:0047936 name: glucose 1-dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47] synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47] synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47] xref: EC:1.1.1.47 xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN is_a: GO:0004344 ! glucose dehydrogenase activity [Term] id: GO:0047937 name: glucose-1-phosphate phosphodismutase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN] synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41] synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41] synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41] xref: EC:2.7.1.41 xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN xref: RHEA:16397 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047938 name: glucose-6-phosphate 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN] synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15] synonym: "glucose-6 phosphate 1-epimerase activity" EXACT [] xref: EC:5.1.3.15 xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN xref: RHEA:16249 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0047939 name: L-glucuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH." [EC:1.1.1.19, RHEA:14909] synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19] synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19] synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "glucuronate reductase activity" EXACT [] synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] xref: EC:1.1.1.19 xref: KEGG_REACTION:R01481 xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN xref: Reactome:R-HSA-5661256 "AKR1A1 reduces D-glucuronate to L-gulonate" xref: RHEA:14909 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047940 name: glucuronokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+)." [EC:2.7.1.43, RHEA:17005] synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43] synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43] synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43] xref: EC:2.7.1.43 xref: KEGG_REACTION:R01476 xref: MetaCyc:GLUCURONOKINASE-RXN xref: RHEA:17005 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047941 name: glucuronolactone reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH." [EC:1.1.1.20, RHEA:18925] xref: EC:1.1.1.20 xref: KEGG_REACTION:R03183 xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN xref: RHEA:18925 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047942 name: glutamate-ethylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.6, RHEA:20525] synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6] synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6] synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6] xref: EC:6.3.1.6 xref: KEGG_REACTION:R02929 xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN xref: RHEA:20525 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0047943 name: glutamate-methylamine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.12, RHEA:17117] synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12] synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12] xref: EC:6.3.4.12 xref: KEGG_REACTION:R01585 xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN xref: RHEA:17117 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0047944 name: glutamate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H(+)." [EC:2.7.2.13, RHEA:17217] synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13] xref: EC:2.7.2.13 xref: KEGG_REACTION:R00241 xref: MetaCyc:GLUTAMATE-1-KINASE-RXN xref: RHEA:17217 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0047945 name: L-glutamine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, RHEA:10400] synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15] synonym: "glutaminase II activity" RELATED [EC:2.6.1.15] synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15] synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine--pyruvate aminotransferase activity" BROAD [] synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15] synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15] synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15] xref: EC:2.6.1.15 xref: KEGG_REACTION:R00576 xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-893616 "glutamine + pyruvate => 2-oxoglutaramate + alanine" xref: RHEA:10400 is_a: GO:0070548 ! L-glutamine aminotransferase activity [Term] id: GO:0047946 name: glutamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68] xref: EC:2.3.1.68 xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0047947 name: glutamine N-phenylacetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN] synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14] synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14] xref: EC:2.3.1.14 xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN xref: RHEA:21844 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047948 name: glutarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate." [EC:6.2.1.6, RHEA:14169] synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6] synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6] synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6] xref: EC:6.2.1.6 xref: KEGG_REACTION:R02402 xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN xref: RHEA:14169 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0047949 name: glutarate-semialdehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN] synonym: "glutarate semialdehyde dehydrogenase (NAD+) activity" EXACT [] synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20] xref: EC:1.2.1.20 xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:12064 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047950 name: glutathione oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2)." [EC:1.8.3.3, RHEA:24112] synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3] xref: EC:1.8.3.3 xref: KEGG_REACTION:R00120 xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN xref: RHEA:24112 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0047951 name: glutathione thiolesterase activity namespace: molecular_function def: "Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+)." [EC:3.1.2.7, RHEA:22708] synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7] synonym: "glutathione thioesterase activity" EXACT [] synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7] xref: EC:3.1.2.7 xref: KEGG_REACTION:R00547 xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN xref: RHEA:22708 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0047952 name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function alt_id: GO:0036439 def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN] synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94] synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] synonym: "glycerol-3-phosphate dehydrogenase [NADP+] activity" EXACT [] synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94] synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94] xref: EC:1.1.1.94 xref: KEGG_REACTION:R00844 xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN xref: RHEA:11096 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: rfoulger creation_date: 2013-09-30T10:37:46Z [Term] id: GO:0047953 name: glycerol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH." [EC:1.1.1.156, RHEA:12753] synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156] synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156] synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156] xref: EC:1.1.1.156 xref: KEGG_REACTION:R01039 xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN xref: RHEA:12753 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047954 name: glycerol-2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate." [EC:3.1.3.19, RHEA:13105] synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19] synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19] synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19] xref: EC:3.1.3.19 xref: KEGG_REACTION:R01043 xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN xref: RHEA:13105 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0047955 name: glycerol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: A + glycerol = AH(2) + glycerone." [EC:1.1.99.22, RHEA:17493] synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22] synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22] xref: EC:1.1.99.22 xref: KEGG_REACTION:R01045 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:17493 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047956 name: glycerol dehydrogenase [NADP+] activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN] synonym: "glycerol dehydrogenase (NADP+) activity" RELATED [] synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72] xref: EC:1.1.1.72 xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN xref: RHEA:23592 is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity [Term] id: GO:0047957 name: 4'-methoxyisoflavone 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.14.89, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN] synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.14.89] synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.14.89] xref: EC:1.14.14.89 xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN xref: RHEA:12388 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0047958 name: glycine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] synonym: "glutamate-glyoxylate transaminase activity" EXACT [] synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4] synonym: "glycine aminotransferase activity" BROAD [] synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4] synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4] synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4] synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT [] xref: EC:2.6.1.4 xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN xref: RHEA:14089 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0047959 name: glycine dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1] synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1] synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1] xref: EC:1.4.2.1 xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor [Term] id: GO:0047960 name: glycine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN] synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10] xref: EC:1.4.1.10 xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN xref: RHEA:15721 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0047961 name: glycine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13] synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13] xref: EC:2.3.1.13 xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1" is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0047962 name: glycine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)." [EC:2.3.1.71, RHEA:18493] synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71] synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71] xref: EC:2.3.1.71 xref: KEGG_REACTION:R02452 xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN xref: Reactome:R-HSA-159566 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A" xref: Reactome:R-HSA-159574 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A" xref: RHEA:18493 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047963 name: glycine N-choloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN] synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "BACAT activity" EXACT [EC:2.3.1.65] synonym: "BAT activity" EXACT [EC:2.3.1.65] synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] xref: EC:2.3.1.65 xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN xref: RHEA:14001 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0047964 name: glyoxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] synonym: "glycolate reductase activity" EXACT [] synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26] synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26] xref: EC:1.1.1.26 xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN xref: RHEA:18229 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047965 name: glycoprotein O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142] synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142] xref: EC:2.3.1.142 xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN is_a: GO:0016416 ! O-palmitoyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0047966 name: glycosulfatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate." [EC:3.1.6.3, RHEA:19145] synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3] synonym: "glycosulphatase activity" EXACT [] synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3] xref: EC:3.1.6.3 xref: KEGG_REACTION:R00534 xref: MetaCyc:GLYCOSULFATASE-RXN xref: RHEA:19145 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0047967 name: glycyrrhizinate beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, RHEA:17369] synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinate b-glucuronidase activity" EXACT [] synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128] synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128] xref: EC:3.2.1.128 xref: KEGG_REACTION:R03906 xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN xref: RHEA:17369 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0047968 name: glyoxylate dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA." [EC:1.2.1.17, RHEA:21024] synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17] xref: EC:1.2.1.17 xref: KEGG_REACTION:R00468 xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN xref: RHEA:21024 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0047969 name: glyoxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate." [EC:1.2.3.5, RHEA:14837] synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5] xref: EC:1.2.3.5 xref: KEGG_REACTION:R00466 xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN xref: Reactome:R-HSA-389862 "Conversion of glyoxylate to oxalate" xref: RHEA:14837 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0047970 name: guanidinoacetase activity namespace: molecular_function def: "Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea." [EC:3.5.3.2, RHEA:23268] synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2] synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2] xref: EC:3.5.3.2 xref: KEGG_REACTION:R00775 xref: MetaCyc:GUANIDINOACETASE-RXN xref: RHEA:23268 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047971 name: guanidinobutyrase activity namespace: molecular_function def: "Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea." [EC:3.5.3.7, RHEA:19501] synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7] synonym: "G-base activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7] synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7] synonym: "GBH" RELATED [EC:3.5.3.7] synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7] xref: EC:3.5.3.7 xref: KEGG_REACTION:R01990 xref: MetaCyc:GUANIDINOBUTYRASE-RXN xref: RHEA:19501 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047972 name: guanidinopropionase activity namespace: molecular_function def: "Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea." [EC:3.5.3.17, RHEA:16029] synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17] synonym: "GPase activity" EXACT [EC:3.5.3.17] synonym: "GPH" RELATED [EC:3.5.3.17] xref: EC:3.5.3.17 xref: KEGG_REACTION:R00913 xref: MetaCyc:GUANIDINOPROPIONASE-RXN xref: RHEA:16029 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0047973 name: guanidinoacetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate." [EC:2.7.3.1, RHEA:14145] synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1] synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1] synonym: "guanidoacetate kinase activity" EXACT [] xref: EC:2.7.3.1 xref: KEGG_REACTION:R02575 xref: MetaCyc:GUANIDOACETATE-KINASE-RXN xref: RHEA:14145 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0047974 name: guanosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN] synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15] synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15] xref: EC:3.5.4.15 xref: MetaCyc:GUANOSINE-DEAMINASE-RXN xref: RHEA:12861 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0047975 name: guanosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN] synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15] synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15] xref: EC:2.4.2.15 xref: MetaCyc:GUANPHOSPHOR-RXN xref: RHEA:13233 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0047976 name: hamamelose kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+)." [EC:2.7.1.102, RHEA:22796] synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102] synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102] xref: EC:2.7.1.102 xref: KEGG_REACTION:R03766 xref: MetaCyc:HAMAMELOSE-KINASE-RXN xref: RHEA:22796 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047977 name: hepoxilin-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN] synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7] synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7] synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7] xref: EC:3.3.2.7 xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN xref: Reactome:R-HSA-2161949 "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH" xref: RHEA:16665 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0047978 name: hexadecanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN] synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164] xref: EC:1.1.1.164 xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN xref: RHEA:22056 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047979 name: hexose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5] xref: EC:1.1.3.5 xref: MetaCyc:HEXOSE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047980 name: hippurate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine." [EC:3.5.1.32, RHEA:10424] synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32] synonym: "hippuricase activity" EXACT [EC:3.5.1.32] synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32] xref: EC:3.5.1.32 xref: KEGG_REACTION:R01424 xref: MetaCyc:HIPPURATE-HYDROLASE-RXN xref: RHEA:10424 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0047981 name: histidine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)." [EC:2.3.1.33, RHEA:24596] synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33] synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33] synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33] xref: EC:2.3.1.33 xref: KEGG_REACTION:R01160 xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:24596 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0047982 name: homocysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN] synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2] synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2] xref: EC:4.4.1.2 xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN xref: Reactome:R-HSA-1614631 "Homocysteine is degraded to oxobutanoate and H2S" xref: RHEA:14501 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0047983 name: homoglutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.23, RHEA:17993] synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23] synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23] synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23] xref: EC:6.3.2.23 xref: KEGG_REACTION:R02741 xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN xref: RHEA:17993 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0047985 name: hydrogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] synonym: "hydrogenase activity" BROAD [EC:1.12.1.2] synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2] xref: EC:1.12.1.2 xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN xref: RHEA:24636 is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: GO:0047986 name: hydrogen-sulfide S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." [EC:2.3.1.10, RHEA:16625] synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10] synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT [] xref: EC:2.3.1.10 xref: KEGG_REACTION:R01850 xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN xref: RHEA:16625 is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0047987 name: hydroperoxide dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: EC:4.2.1.92 xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN xref: RHEA:25075 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0047988 name: hydroxyacid-oxoacid transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24] synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24] xref: EC:1.1.99.24 xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN xref: Reactome:R-HSA-880002 "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate" xref: Reactome:R-HSA-880033 "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0047989 name: hydroxybutyrate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+)." [EC:3.1.1.22, RHEA:10172] synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22] synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22] xref: EC:3.1.1.22 xref: KEGG_REACTION:R00048 xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN xref: RHEA:10172 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047990 name: hydroxyglutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2)." [EC:4.1.1.16, RHEA:14073] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16] synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16] xref: EC:4.1.1.16 xref: KEGG_REACTION:R04135 xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN xref: RHEA:14073 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047991 name: hydroxylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite." [EC:1.7.3.4, RHEA:19969] synonym: "HAO" RELATED [EC:1.7.3.4] synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4] synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4] xref: EC:1.7.3.4 xref: KEGG_REACTION:R00793 xref: MetaCyc:HAONITRO-RXN xref: RHEA:19969 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0047992 name: hydroxylysine kinase activity namespace: molecular_function def: "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+)." [EC:2.7.1.81, RHEA:19049] synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81] xref: EC:2.7.1.81 xref: KEGG_REACTION:R03378 xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN xref: Reactome:R-HSA-6788611 "HYKK phosphorylates 5HLYS" xref: RHEA:19049 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0047993 name: hydroxymalonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate." [EC:1.1.1.167, RHEA:11284] synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167] xref: EC:1.1.1.167 xref: KEGG_REACTION:R02969 xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN xref: RHEA:11284 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047994 name: hydroxymethylglutaryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+)." [EC:3.1.2.5, RHEA:16305] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] xref: EC:3.1.2.5 xref: KEGG_REACTION:R02083 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN xref: RHEA:16305 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0047995 name: hydroxyphenylpyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN] synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237] synonym: "HPRP" RELATED [EC:1.1.1.237] xref: EC:1.1.1.237 xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN xref: RHEA:23364 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0047996 name: hydroxyphytanate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2)." [EC:1.1.3.27, RHEA:21680] synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27] xref: EC:1.1.3.27 xref: KEGG_REACTION:R07151 xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN xref: RHEA:21680 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0047997 name: hydroxypyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde." [EC:4.1.1.40, RHEA:20561] synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40] synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40] xref: EC:4.1.1.40 xref: KEGG_REACTION:R01393 xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN xref: RHEA:20561 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0047998 name: hyoscyamine (6S)-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate." [EC:1.14.11.11, RHEA:12629] synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11] synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11] synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11] xref: EC:1.14.11.11 xref: KEGG_REACTION:R03812 xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN xref: RHEA:12629 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0047999 name: hyponitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH." [EC:1.7.1.5, RHEA:19337] synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] xref: EC:1.7.1.5 xref: KEGG_REACTION:R00023 xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN xref: RHEA:19337 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0048000 name: isoflavone 3'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.14.88, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN] synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.88] synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.14.88] xref: EC:1.14.14.88 xref: MetaCyc:RXN-3762 xref: RHEA:22960 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0048001 name: erythrose-4-phosphate dehydrogenase activity namespace: molecular_function alt_id: GO:0033724 def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH." [EC:1.2.1.72, RHEA:12056] synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72] synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "E4PDH" EXACT [EC:1.2.1.72] synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72] synonym: "GapB" RELATED [EC:1.2.1.72] xref: EC:1.2.1.72 xref: KEGG_REACTION:R01825 xref: MetaCyc:ERYTH4PDEHYDROG-RXN xref: RHEA:12056 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0048002 name: antigen processing and presentation of peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, peptide antigen" EXACT [] synonym: "peptide antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0048003 name: antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, lipid antigen" EXACT [] synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0048006 name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, endogenous lipid antigen" EXACT [] synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0048007 name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] synonym: "antigen presentation, exogenous peptide antigen" EXACT [] synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0048008 name: platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "PDGF receptor signaling pathway" EXACT [] synonym: "PDGF receptor signalling pathway" EXACT [] synonym: "PDGFR signaling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048009 name: insulin-like growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "IGF receptor signaling pathway" EXACT [] synonym: "IGF receptor signalling pathway" EXACT [] xref: MIPS_funcat:30.05.01.12.04 is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048010 name: vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling, PR:000001971] comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. synonym: "VEGF receptor signaling pathway" EXACT [] synonym: "VEGF receptor signalling pathway" EXACT [] synonym: "VEGFR signaling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048011 name: neurotrophin TRK receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor] synonym: "TrkA signaling pathway" NARROW [Wikipedia:TrkA] synonym: "TrkB signaling pathway" NARROW [Wikipedia:TrkB] synonym: "TrkC signaling pathway" NARROW [Wikipedia:TrkC] synonym: "tropomyosin-receptor-kinase signaling" EXACT [Wikipedia:Trk_receptor] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0038179 ! neurotrophin signaling pathway [Term] id: GO:0048012 name: hepatocyte growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "HGF receptor signaling pathway" EXACT [] synonym: "HGF receptor signalling pathway" EXACT [] synonym: "Met signaling pathway" NARROW [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048013 name: ephrin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] synonym: "Eph receptor signaling pathway" EXACT [] synonym: "Eph receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048014 name: Tie signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a Tie protein (a receptor) binding to one of its physiological ligands (an angiopoietin)." [GOC:ceb, GOC:signaling, PMID:11283723, PMID:11566266] synonym: "angiopoietin-Tie signaling pathway" NARROW [PMID:22951441] synonym: "angiopoietin/Tie signaling pathway" NARROW [PMID:11566266] synonym: "Tek receptor signaling" EXACT [] synonym: "Tie receptor signaling pathway" EXACT [GOC:ceb] synonym: "Tie receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0048015 name: phosphatidylinositol-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732] synonym: "inositol phospholipid-mediated signaling" BROAD [] synonym: "phosphatidylinositol-mediated signal transduction" EXACT [GOC:signaling] synonym: "phosphatidylinositol-mediated signalling" EXACT [] synonym: "phosphoinositide-mediated signaling" EXACT [] synonym: "phosphoinositide-mediated signalling" EXACT [] is_a: GO:0048017 ! inositol lipid-mediated signaling [Term] id: GO:0048016 name: inositol phosphate-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907] synonym: "inositol phosphate-mediated signalling" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0048017 name: inositol lipid-mediated signaling namespace: biological_process def: "A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939] synonym: "inositol lipid-mediated signal transduction" EXACT [GOC:signaling] synonym: "inositol lipid-mediated signalling" EXACT [] synonym: "inositol phospholipid-mediated signaling" NARROW [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0048018 name: receptor ligand activity namespace: molecular_function alt_id: GO:0071884 def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] comment: Definition discussed in https://github.com/geneontology/go-ontology/issues/14220 subset: goslim_chembl subset: goslim_drosophila synonym: "receptor agonist activity" BROAD [GOC:molecular_function_refactoring] synonym: "signaling molecule" EXACT [] synonym: "signaling receptor ligand activity" EXACT [] synonym: "vitamin D receptor activator activity" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0030546 ! signaling receptor activator activity relationship: part_of GO:0007165 ! signal transduction created_by: midori creation_date: 2010-09-13T04:51:59Z [Term] id: GO:0048019 name: receptor antagonist activity namespace: molecular_function def: "The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732] synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0030547 ! receptor inhibitor activity [Term] id: GO:0048020 name: CCR chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR chemokine receptor." [GOC:ai] synonym: "beta chemokine receptor binding" EXACT [] synonym: "beta chemokine receptor ligand" NARROW [] synonym: "CCR chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0048021 name: regulation of melanin biosynthetic process namespace: biological_process def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] synonym: "regulation of melanin anabolism" EXACT [] synonym: "regulation of melanin biosynthesis" EXACT [] synonym: "regulation of melanin formation" EXACT [] synonym: "regulation of melanin synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042438 ! melanin biosynthetic process relationship: regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048022 name: negative regulation of melanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] synonym: "down regulation of melanin biosynthetic process" EXACT [] synonym: "down-regulation of melanin biosynthetic process" EXACT [] synonym: "downregulation of melanin biosynthetic process" EXACT [] synonym: "inhibition of melanin biosynthetic process" NARROW [] synonym: "negative regulation of melanin anabolism" EXACT [] synonym: "negative regulation of melanin biosynthesis" EXACT [] synonym: "negative regulation of melanin formation" EXACT [] synonym: "negative regulation of melanin synthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0048021 ! regulation of melanin biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042438 ! melanin biosynthetic process relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048023 name: positive regulation of melanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] synonym: "activation of melanin biosynthetic process" NARROW [] synonym: "positive regulation of melanin anabolism" EXACT [] synonym: "positive regulation of melanin biosynthesis" EXACT [] synonym: "positive regulation of melanin formation" EXACT [] synonym: "positive regulation of melanin synthesis" EXACT [] synonym: "stimulation of melanin biosynthetic process" NARROW [] synonym: "up regulation of melanin biosynthetic process" EXACT [] synonym: "up-regulation of melanin biosynthetic process" EXACT [] synonym: "upregulation of melanin biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0048021 ! regulation of melanin biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042438 ! melanin biosynthetic process relationship: positively_regulates GO:0042438 ! melanin biosynthetic process [Term] id: GO:0048024 name: regulation of mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035055 def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "regulation of pre-mRNA splicing" BROAD [] is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0050684 ! regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000398 ! mRNA splicing, via spliceosome relationship: regulates GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0048025 name: negative regulation of mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035056 def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "negative regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "negative regulation of pre-mRNA splicing" BROAD [] is_a: GO:0033119 ! negative regulation of RNA splicing is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome is_a: GO:0050686 ! negative regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome relationship: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0048026 name: positive regulation of mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0035057 def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "positive regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "positive regulation of pre-mRNA splicing" BROAD [] synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW [] synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT [] is_a: GO:0033120 ! positive regulation of RNA splicing is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome is_a: GO:0050685 ! positive regulation of mRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome relationship: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0048027 name: mRNA 5'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jid] synonym: "mRNA 5' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0048028 name: galacturonan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jid] synonym: "polygalacturonide binding" RELATED [] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] is_a: GO:0030246 ! carbohydrate binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0048030 name: disaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jid] is_a: GO:0070492 ! oligosaccharide binding [Term] id: GO:0048031 name: trisaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jid] is_a: GO:0070492 ! oligosaccharide binding [Term] id: GO:0048032 name: galacturonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:jid] synonym: "galacturonic acid binding" EXACT [] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0048033 name: heme o metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] synonym: "haem o metabolic process" EXACT [] synonym: "haem o metabolism" EXACT [] synonym: "heme o metabolism" EXACT [] is_a: GO:0042168 ! heme metabolic process [Term] id: GO:0048034 name: heme O biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] synonym: "haem O biosynthesis" EXACT [] synonym: "haem O biosynthetic process" EXACT [] synonym: "heme O anabolism" EXACT [] synonym: "heme O biosynthesis" EXACT [] synonym: "heme O formation" EXACT [] synonym: "heme O synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0048033 ! heme o metabolic process [Term] id: GO:0048035 name: heme o catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] synonym: "haem o catabolic process" EXACT [] synonym: "haem o catabolism" EXACT [] synonym: "heme o breakdown" EXACT [] synonym: "heme o catabolism" EXACT [] synonym: "heme o degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0048033 ! heme o metabolic process [Term] id: GO:0048036 name: central complex development namespace: biological_process def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] synonym: "central body development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0048037 name: cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] subset: goslim_pir xref: MIPS_funcat:16.21 is_a: GO:0005488 ! binding [Term] id: GO:0048038 name: quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] is_a: GO:0048037 ! cofactor binding [Term] id: GO:0048039 name: ubiquinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089] synonym: "coenzyme Q binding" EXACT [] synonym: "coenzyme Q6 binding" NARROW [] is_a: GO:0048038 ! quinone binding [Term] id: GO:0048040 name: UDP-glucuronate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23916] synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35] synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35] synonym: "UDP-glucuronic acid decarboxylase activity" EXACT [] synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] xref: EC:4.1.1.35 xref: KEGG_REACTION:R01384 xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN xref: RHEA:23916 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0048041 name: focal adhesion assembly namespace: biological_process def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] synonym: "adhesion plaque assembly" RELATED [] synonym: "focal adhesion formation" RELATED [GOC:mah] is_a: GO:0007044 ! cell-substrate junction assembly relationship: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0048042 name: regulation of post-mating oviposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766] synonym: "regulation of oviposition, post-mating" EXACT [GOC:dph, GOC:tb] is_a: GO:0046662 ! regulation of oviposition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060403 ! post-mating oviposition relationship: regulates GO:0060403 ! post-mating oviposition [Term] id: GO:0048045 name: trans-pentaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate." [RHEA:22632] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.-] synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.-] synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.-] synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT [] xref: EC:2.5.1 xref: KEGG_REACTION:R05613 xref: RHEA:22632 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0048046 name: apoplast namespace: cellular_component def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid] xref: Wikipedia:Apoplast is_a: GO:0005576 ! extracellular region [Term] id: GO:0048047 name: mating behavior, sex discrimination namespace: biological_process def: "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] synonym: "mating behaviour, sex discrimination" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0048048 name: embryonic eye morphogenesis namespace: biological_process def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048050 name: post-embryonic eye morphogenesis namespace: biological_process alt_id: GO:0048051 def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight." [GOC:jid, GOC:sensu] is_a: GO:0048563 ! post-embryonic animal organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048052 name: R1/R6 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048053 name: R1/R6 development namespace: biological_process def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0048054 name: R2/R5 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048055 name: R2/R5 development namespace: biological_process def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0048056 name: R3/R4 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0048057 name: R3/R4 development namespace: biological_process def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] is_a: GO:0042051 ! compound eye photoreceptor development relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0048058 name: compound eye corneal lens development namespace: biological_process def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0048060 name: negative gravitaxis namespace: biological_process alt_id: GO:0048063 def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] synonym: "negative geotactic behavior" EXACT [] synonym: "negative geotactic behaviour" EXACT [] synonym: "negative gravitactic behavior" EXACT [] synonym: "negative gravitactic behaviour" EXACT [] synonym: "negative taxis in response to gravity" EXACT [] synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] is_a: GO:0042332 ! gravitaxis [Term] id: GO:0048061 name: positive gravitaxis namespace: biological_process alt_id: GO:0048064 def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jid] synonym: "positive geotactic behavior" EXACT [] synonym: "positive geotactic behaviour" EXACT [] synonym: "positive gravitactic behavior" EXACT [] synonym: "positive gravitactic behaviour" EXACT [] synonym: "positive taxis in response to gravity" EXACT [] synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] is_a: GO:0042332 ! gravitaxis [Term] id: GO:0048065 name: male courtship behavior, veined wing extension namespace: biological_process def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] synonym: "male courtship behavior, wing extension" BROAD [] synonym: "male courtship behaviour, veined wing extension" EXACT [] synonym: "male courtship behaviour, wing extension" BROAD [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0048066 name: developmental pigmentation namespace: biological_process def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] synonym: "pigmentation during development" RELATED [] is_a: GO:0043473 ! pigmentation [Term] id: GO:0048067 name: cuticle pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] is_a: GO:0048066 ! developmental pigmentation relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0048069 name: eye pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jid] xref: Wikipedia:Eye_color is_a: GO:0048066 ! developmental pigmentation [Term] id: GO:0048070 name: regulation of developmental pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048066 ! developmental pigmentation relationship: regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048071 name: sex-specific pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048066 ! developmental pigmentation relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0048072 name: compound eye pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in the compound eye." [GOC:jid] is_a: GO:0048069 ! eye pigmentation [Term] id: GO:0048073 name: regulation of eye pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048069 ! eye pigmentation relationship: regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048074 name: negative regulation of eye pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] synonym: "down regulation of eye pigmentation" EXACT [] synonym: "down-regulation of eye pigmentation" EXACT [] synonym: "downregulation of eye pigmentation" EXACT [] synonym: "inhibition of eye pigmentation" NARROW [] is_a: GO:0048073 ! regulation of eye pigmentation is_a: GO:0048086 ! negative regulation of developmental pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048069 ! eye pigmentation relationship: negatively_regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048075 name: positive regulation of eye pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] synonym: "activation of eye pigmentation" NARROW [] synonym: "stimulation of eye pigmentation" NARROW [] synonym: "up regulation of eye pigmentation" EXACT [] synonym: "up-regulation of eye pigmentation" EXACT [] synonym: "upregulation of eye pigmentation" EXACT [] is_a: GO:0048073 ! regulation of eye pigmentation is_a: GO:0048087 ! positive regulation of developmental pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048069 ! eye pigmentation relationship: positively_regulates GO:0048069 ! eye pigmentation [Term] id: GO:0048076 name: regulation of compound eye pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] is_a: GO:0048073 ! regulation of eye pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048072 ! compound eye pigmentation relationship: regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048077 name: negative regulation of compound eye pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] synonym: "down regulation of eye pigmentation" BROAD [] synonym: "down-regulation of eye pigmentation" BROAD [] synonym: "downregulation of eye pigmentation" BROAD [] synonym: "inhibition of eye pigmentation" BROAD [] synonym: "negative regulation of eye pigmentation" BROAD [] is_a: GO:0048074 ! negative regulation of eye pigmentation is_a: GO:0048076 ! regulation of compound eye pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048072 ! compound eye pigmentation relationship: negatively_regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048078 name: positive regulation of compound eye pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] synonym: "activation of eye pigmentation" BROAD [] synonym: "positive regulation of eye pigmentation" BROAD [] synonym: "stimulation of eye pigmentation" BROAD [] synonym: "up regulation of eye pigmentation" BROAD [] synonym: "up-regulation of eye pigmentation" BROAD [] synonym: "upregulation of eye pigmentation" BROAD [] is_a: GO:0048075 ! positive regulation of eye pigmentation is_a: GO:0048076 ! regulation of compound eye pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048072 ! compound eye pigmentation relationship: positively_regulates GO:0048072 ! compound eye pigmentation [Term] id: GO:0048079 name: regulation of cuticle pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048067 ! cuticle pigmentation relationship: regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048080 name: negative regulation of cuticle pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] synonym: "down regulation of cuticle pigmentation" EXACT [] synonym: "down-regulation of cuticle pigmentation" EXACT [] synonym: "downregulation of cuticle pigmentation" EXACT [] synonym: "inhibition of cuticle pigmentation" NARROW [] is_a: GO:0048079 ! regulation of cuticle pigmentation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048067 ! cuticle pigmentation relationship: negatively_regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048081 name: positive regulation of cuticle pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] synonym: "activation of cuticle pigmentation" NARROW [] synonym: "stimulation of cuticle pigmentation" NARROW [] synonym: "up regulation of cuticle pigmentation" EXACT [] synonym: "up-regulation of cuticle pigmentation" EXACT [] synonym: "upregulation of cuticle pigmentation" EXACT [] is_a: GO:0048079 ! regulation of cuticle pigmentation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048067 ! cuticle pigmentation relationship: positively_regulates GO:0048067 ! cuticle pigmentation [Term] id: GO:0048082 name: regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] is_a: GO:0007564 ! regulation of chitin-based cuticle tanning is_a: GO:0048079 ! regulation of cuticle pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048083 name: negative regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW [] is_a: GO:0045800 ! negative regulation of chitin-based cuticle tanning is_a: GO:0048080 ! negative regulation of cuticle pigmentation is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048084 name: positive regulation of adult chitin-containing cuticle pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW [] synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW [] synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT [] synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT [] is_a: GO:0045801 ! positive regulation of chitin-based cuticle tanning is_a: GO:0048081 ! positive regulation of cuticle pigmentation is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation [Term] id: GO:0048085 name: adult chitin-containing cuticle pigmentation namespace: biological_process alt_id: GO:0048068 def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] synonym: "adult cuticle pigmentation" BROAD [] is_a: GO:0048067 ! cuticle pigmentation relationship: part_of GO:0007593 ! chitin-based cuticle sclerotization [Term] id: GO:0048086 name: negative regulation of developmental pigmentation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of pigmentation" NARROW [] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048066 ! developmental pigmentation relationship: negatively_regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048087 name: positive regulation of developmental pigmentation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, goc:tb] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048066 ! developmental pigmentation relationship: positively_regulates GO:0048066 ! developmental pigmentation [Term] id: GO:0048088 name: regulation of male pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048094 ! male pigmentation relationship: regulates GO:0048094 ! male pigmentation [Term] id: GO:0048089 name: regulation of female pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048095 ! female pigmentation relationship: regulates GO:0048095 ! female pigmentation [Term] id: GO:0048090 name: negative regulation of female pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] synonym: "down regulation of female pigmentation" EXACT [] synonym: "down-regulation of female pigmentation" EXACT [] synonym: "downregulation of female pigmentation" EXACT [] synonym: "inhibition of female pigmentation" NARROW [] is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0048089 ! regulation of female pigmentation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048095 ! female pigmentation relationship: negatively_regulates GO:0048095 ! female pigmentation [Term] id: GO:0048091 name: positive regulation of female pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] synonym: "activation of female pigmentation" NARROW [] synonym: "stimulation of female pigmentation" NARROW [] synonym: "up regulation of female pigmentation" EXACT [] synonym: "up-regulation of female pigmentation" EXACT [] synonym: "upregulation of female pigmentation" EXACT [] is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0048089 ! regulation of female pigmentation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048095 ! female pigmentation relationship: positively_regulates GO:0048095 ! female pigmentation [Term] id: GO:0048092 name: negative regulation of male pigmentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] synonym: "down regulation of male pigmentation" EXACT [] synonym: "down-regulation of male pigmentation" EXACT [] synonym: "downregulation of male pigmentation" EXACT [] synonym: "inhibition of male pigmentation" NARROW [] is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0048088 ! regulation of male pigmentation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048094 ! male pigmentation relationship: negatively_regulates GO:0048094 ! male pigmentation [Term] id: GO:0048093 name: positive regulation of male pigmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] synonym: "activation of male pigmentation" NARROW [] synonym: "stimulation of male pigmentation" NARROW [] synonym: "up regulation of male pigmentation" EXACT [] synonym: "up-regulation of male pigmentation" EXACT [] synonym: "upregulation of male pigmentation" EXACT [] is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0048088 ! regulation of male pigmentation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048094 ! male pigmentation relationship: positively_regulates GO:0048094 ! male pigmentation [Term] id: GO:0048094 name: male pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in males." [GOC:jid] is_a: GO:0048071 ! sex-specific pigmentation relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0048095 name: female pigmentation namespace: biological_process def: "Establishment of a pattern of pigment in females." [GOC:jid] is_a: GO:0048071 ! sex-specific pigmentation relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0048096 name: chromatin-mediated maintenance of transcription namespace: biological_process def: "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jid] comment: Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. is_a: GO:0034401 ! chromatin organization involved in regulation of transcription is_a: GO:0045815 ! positive regulation of gene expression, epigenetic is_a: GO:0045893 ! positive regulation of transcription, DNA-templated [Term] id: GO:0048097 name: long-term maintenance of gene activation namespace: biological_process def: "Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jid] comment: Note that this process is the opposite of gene silencing. is_a: GO:0045815 ! positive regulation of gene expression, epigenetic [Term] id: GO:0048098 name: antennal joint development namespace: biological_process def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007469 ! antennal development [Term] id: GO:0048099 name: anterior/posterior lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007448 ! anterior/posterior pattern specification, imaginal disc [Term] id: GO:0048100 name: wing disc anterior/posterior pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0048101 name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jid] synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED [] synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT [] synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity [Term] id: GO:0048102 name: autophagic cell death namespace: biological_process def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. synonym: "autophagic death" BROAD [] synonym: "autosis" RELATED [PMID:25236395] synonym: "programmed cell death by autophagy" BROAD [GOC:pr] synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] synonym: "type II programmed cell death" RELATED [GOC:sl] is_a: GO:0012501 ! programmed cell death intersection_of: GO:0012501 ! programmed cell death intersection_of: has_part GO:0016236 ! macroautophagy relationship: has_part GO:0016236 ! macroautophagy [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division [Term] id: GO:0048104 name: establishment of body hair or bristle planar orientation namespace: biological_process def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity [Term] id: GO:0048105 name: establishment of body hair planar orientation namespace: biological_process def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] is_a: GO:0048104 ! establishment of body hair or bristle planar orientation [Term] id: GO:0048106 name: establishment of thoracic bristle planar orientation namespace: biological_process def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [FBbt:00004298, FBbt:00004408, GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] synonym: "establishment of body bristle planar orientation" EXACT [GOC:bf] is_a: GO:0048104 ! establishment of body hair or bristle planar orientation relationship: part_of GO:0008407 ! chaeta morphogenesis [Term] id: GO:0048107 name: 4-amino-3-isothiazolidinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jid] synonym: "4-amino-3-isothiazolidinone anabolism" EXACT [] synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT [] synonym: "4-amino-3-isothiazolidinone formation" EXACT [] synonym: "4-amino-3-isothiazolidinone synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0048108 name: peptide cross-linking via 4-amino-3-isothiazolidinone namespace: biological_process def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jid, GOC:jsg] comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link. is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0048109 name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344] xref: RESID:AA0344 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone [Term] id: GO:0048132 name: female germ-line stem cell asymmetric division namespace: biological_process alt_id: GO:0048141 def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] synonym: "female germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0048133 name: male germ-line stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid] synonym: "male germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048134 name: germ-line cyst formation namespace: biological_process def: "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] synonym: "germline cyst formation" EXACT [PMID:10370240] is_a: GO:0008283 ! cell population proliferation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0048135 name: female germ-line cyst formation namespace: biological_process def: "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240] synonym: "female germline cyst formation" EXACT [PMID:10370240] is_a: GO:0048134 ! germ-line cyst formation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0048136 name: male germ-line cyst formation namespace: biological_process def: "Formation of a group of interconnected cells derived from a single male gonial founder cell." [GOC:jid, PMID:10370240] synonym: "male germline cyst formation" EXACT [PMID:10370240] is_a: GO:0048134 ! germ-line cyst formation relationship: has_part GO:0007284 ! spermatogonial cell division relationship: has_part GO:0048137 ! spermatocyte division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048137 name: spermatocyte division namespace: biological_process def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] synonym: "spermatocyte cell division" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048138 name: germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007276 ! gamete generation relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium [Term] id: GO:0048139 name: female germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid] is_a: GO:0048138 ! germ-line cyst encapsulation relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0048140 name: male germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336] is_a: GO:0048138 ! germ-line cyst encapsulation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048142 name: germarium-derived cystoblast division namespace: biological_process def: "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] synonym: "germarium-derived cystoblast cell division" EXACT [] is_a: GO:0007282 ! cystoblast division relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation [Term] id: GO:0048143 name: astrocyte activation namespace: biological_process def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] is_a: GO:0061900 ! glial cell activation relationship: part_of GO:0014002 ! astrocyte development [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048144 ! fibroblast proliferation relationship: regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048144 ! fibroblast proliferation relationship: positively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048144 ! fibroblast proliferation relationship: negatively_regulates GO:0048144 ! fibroblast proliferation [Term] id: GO:0048148 name: behavioral response to cocaine namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] synonym: "behavioural response to cocaine" EXACT [] is_a: GO:0030534 ! adult behavior relationship: part_of GO:0042220 ! response to cocaine [Term] id: GO:0048149 name: behavioral response to ethanol namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] synonym: "behavioural response to ethanol" EXACT [] is_a: GO:0030534 ! adult behavior relationship: part_of GO:0045471 ! response to ethanol [Term] id: GO:0048150 name: behavioral response to ether namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid] synonym: "behavioural response to ether" EXACT [] is_a: GO:0030534 ! adult behavior relationship: part_of GO:0045472 ! response to ether [Term] id: GO:0048151 name: obsolete hyperphosphorylation namespace: biological_process def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jid, ISBN:039751820X, PMID:12859672] comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined. synonym: "hyperphosphorylation" EXACT [] is_obsolete: true replaced_by: GO:0016310 [Term] id: GO:0048152 name: S100 beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] synonym: "S100 beta anabolism" EXACT [] synonym: "S100 beta biosynthesis" EXACT [] synonym: "S100 beta formation" EXACT [] synonym: "S100 beta synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0048153 name: S100 alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] synonym: "S100 alpha anabolism" EXACT [] synonym: "S100 alpha biosynthesis" EXACT [] synonym: "S100 alpha formation" EXACT [] synonym: "S100 alpha synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0048156 name: tau protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0048158 name: oogonium stage namespace: biological_process def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 1" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048159 name: primary oocyte stage namespace: biological_process def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 2" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048160 name: primary follicle stage namespace: biological_process def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 3" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048161 name: double layer follicle stage namespace: biological_process def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 4" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048162 name: multi-layer follicle stage namespace: biological_process def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 5" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048163 name: scattered antral spaces stage namespace: biological_process def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 6" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048164 name: distinct antral spaces stage namespace: biological_process def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 7" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048165 name: fused antrum stage namespace: biological_process def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 8" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048166 name: mature follicle stage namespace: biological_process def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] synonym: "mammalian oogenesis stage 9" EXACT [] is_a: GO:0022605 ! mammalian oogenesis stage [Term] id: GO:0048167 name: regulation of synaptic plasticity namespace: biological_process def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0048168 name: regulation of neuronal synaptic plasticity namespace: biological_process def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0048169 name: regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0048170 name: positive regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of long-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW [] synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT [] is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity is_a: GO:0050769 ! positive regulation of neurogenesis [Term] id: GO:0048171 name: negative regulation of long-term neuronal synaptic plasticity namespace: biological_process def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW [] is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity is_a: GO:0050768 ! negative regulation of neurogenesis [Term] id: GO:0048172 name: regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0048173 name: positive regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of short-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW [] synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT [] is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity is_a: GO:0050769 ! positive regulation of neurogenesis [Term] id: GO:0048174 name: negative regulation of short-term neuronal synaptic plasticity namespace: biological_process def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW [] is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity is_a: GO:0050768 ! negative regulation of neurogenesis [Term] id: GO:0048175 name: hepatocyte growth factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets." [GOC:jid, PMID:1838014] synonym: "hepatocyte growth factor anabolism" EXACT [] synonym: "hepatocyte growth factor biosynthesis" EXACT [] synonym: "hepatocyte growth factor formation" EXACT [] synonym: "hepatocyte growth factor synthesis" EXACT [] synonym: "HGF biosynthesis" EXACT [] synonym: "HGF biosynthetic process" EXACT [] synonym: "scatter factor biosynthesis" EXACT [] synonym: "scatter factor biosynthetic process" EXACT [] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0048176 name: regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "regulation of hepatocyte growth factor formation" EXACT [] synonym: "regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "regulation of HGF biosynthesis" EXACT [] synonym: "regulation of HGF biosynthetic process" EXACT [] synonym: "regulation of scatter factor biosynthesis" EXACT [] synonym: "regulation of scatter factor biosynthetic process" EXACT [] is_a: GO:0032646 ! regulation of hepatocyte growth factor production is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process relationship: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048177 name: positive regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "activation of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "positive regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "positive regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "positive regulation of hepatocyte growth factor formation" EXACT [] synonym: "positive regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "positive regulation of HGF biosynthesis" EXACT [] synonym: "positive regulation of HGF biosynthetic process" EXACT [] synonym: "positive regulation of scatter factor biosynthesis" EXACT [] synonym: "positive regulation of scatter factor biosynthetic process" EXACT [] synonym: "stimulation of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "up regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "up-regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "upregulation of hepatocyte growth factor biosynthetic process" EXACT [] is_a: GO:0032726 ! positive regulation of hepatocyte growth factor production is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process relationship: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048178 name: negative regulation of hepatocyte growth factor biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jid, PMID:1838014] synonym: "down regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "down-regulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "downregulation of hepatocyte growth factor biosynthetic process" EXACT [] synonym: "inhibition of hepatocyte growth factor biosynthetic process" NARROW [] synonym: "negative regulation of hepatocyte growth factor anabolism" EXACT [] synonym: "negative regulation of hepatocyte growth factor biosynthesis" EXACT [] synonym: "negative regulation of hepatocyte growth factor formation" EXACT [] synonym: "negative regulation of hepatocyte growth factor synthesis" EXACT [] synonym: "negative regulation of HGF biosynthesis" EXACT [] synonym: "negative regulation of HGF biosynthetic process" EXACT [] synonym: "negative regulation of scatter factor biosynthesis" EXACT [] synonym: "negative regulation of scatter factor biosynthetic process" EXACT [] is_a: GO:0032686 ! negative regulation of hepatocyte growth factor production is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process relationship: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process [Term] id: GO:0048179 name: activin receptor complex namespace: cellular_component def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651] is_a: GO:0098802 ! plasma membrane signaling receptor complex is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0048180 name: activin complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0048183 name: activin AB complex namespace: cellular_component def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. synonym: "inhibin beta-A" NARROW [] synonym: "inhibin beta-B" NARROW [] is_a: GO:0048180 ! activin complex [Term] id: GO:0048184 name: obsolete follistatin binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the peptide hormone follistatin." [GOC:jid, GOC:mah] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "follistatin binding" EXACT [] is_obsolete: true replaced_by: GO:0017046 [Term] id: GO:0048185 name: activin binding namespace: molecular_function def: "Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0048188 name: Set1C/COMPASS complex namespace: cellular_component def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] synonym: "COMPASS complex" EXACT [GOC:vw] synonym: "Set1/COMPASS complex" EXACT [GOC:mah] synonym: "Set1C" EXACT [GOC:vw] is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0048189 name: Lid2 complex namespace: cellular_component def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0048190 name: wing disc dorsal/ventral pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0048191 name: obsolete peptide stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jid] comment: This term was made obsolete because it represents a biological process. synonym: "peptide stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050822 [Term] id: GO:0048192 name: obsolete peptide antigen stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jid] comment: This term was made obsolete because it represents a biological process. synonym: "peptide antigen stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050823 [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048194 name: Golgi vesicle budding namespace: biological_process def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle budding" NARROW [] synonym: "Golgi-derived vesicle budding" EXACT [] is_a: GO:0006900 ! vesicle budding from membrane relationship: occurs_in GO:0000139 ! Golgi membrane relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048195 name: Golgi membrane priming complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "formation of dictyosome membrane priming complex" NARROW [] synonym: "formation of Golgi membrane priming complex" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0048200 ! Golgi transport vesicle coating [Term] id: GO:0048196 name: obsolete plant extracellular matrix namespace: cellular_component def: "OBSOLETE. The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466] comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell. synonym: "middle lamella-containing extracellular matrix" RELATED [GOC:tb] synonym: "plant extracellular matrix" EXACT [] is_obsolete: true [Term] id: GO:0048197 name: Golgi membrane coat protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW [] synonym: "dictyosome membrane bud coat oligomerisation" NARROW [] synonym: "Golgi membrane bud coat oligomerisation" NARROW [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0048200 ! Golgi transport vesicle coating [Term] id: GO:0048198 name: Golgi vesicle bud deformation and release namespace: biological_process def: "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle bud deformation" NARROW [] synonym: "Golgi-derived vesicle bud deformation and release" EXACT [] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0048194 ! Golgi vesicle budding [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048200 name: Golgi transport vesicle coating namespace: biological_process def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome transport vesicle coating" NARROW [] is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0048194 ! Golgi vesicle budding relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048201 name: vesicle targeting, plasma membrane to endosome namespace: biological_process def: "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "plasma membrane to endosome targeting" EXACT [] is_a: GO:0006903 ! vesicle targeting [Term] id: GO:0048202 name: clathrin coating of Golgi vesicle namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "clathrin coating of Golgi-derived vesicle" EXACT [] is_a: GO:0048200 ! Golgi transport vesicle coating is_a: GO:0048268 ! clathrin coat assembly [Term] id: GO:0048203 name: vesicle targeting, trans-Golgi to endosome namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "trans-Golgi to endosome targeting" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0006895 ! Golgi to endosome transport [Term] id: GO:0048204 name: vesicle targeting, inter-Golgi cisterna namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "inter-Golgi cisterna targeting" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport [Term] id: GO:0048205 name: COPI coating of Golgi vesicle namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "COPI coating of Golgi-derived vesicle" EXACT [] synonym: "COPI vesicle coating" RELATED [GOC:br] is_a: GO:0048200 ! Golgi transport vesicle coating relationship: part_of GO:0035964 ! COPI-coated vesicle budding [Term] id: GO:0048206 name: vesicle targeting, cis-Golgi to rough endoplasmic reticulum namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT [] synonym: "cis-Golgi to rough ER targeting" EXACT [] synonym: "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" EXACT [] synonym: "vesicle targeting, cis-Golgi to rough ER" EXACT [] is_a: GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi is_a: GO:0051650 ! establishment of vesicle localization [Term] id: GO:0048207 name: vesicle targeting, rough ER to cis-Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT [] synonym: "rough ER to cis-Golgi targeting" EXACT [] synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT [] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport [Term] id: GO:0048208 name: COPII vesicle coating namespace: biological_process def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233] synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb] synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0006901 ! vesicle coating is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi relationship: part_of GO:0090114 ! COPII-coated vesicle budding [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi [Term] id: GO:0048210 name: Golgi vesicle fusion to target membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle fusion to target membrane" NARROW [] synonym: "Golgi-derived vesicle fusion to target membrane" EXACT [] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048211 name: Golgi vesicle docking namespace: biological_process def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle docking to target membrane" NARROW [] synonym: "Golgi vesicle docking with target membrane" EXACT [] synonym: "Golgi vesicle to membrane docking" EXACT [] synonym: "Golgi-derived vesicle docking" EXACT [] is_a: GO:0048278 ! vesicle docking relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048212 name: Golgi vesicle uncoating namespace: biological_process def: "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle coat depolymerization" NARROW [] synonym: "Golgi vesicle coat depolymerization" EXACT [] synonym: "Golgi vesicle coat protein depolymerization" EXACT [] synonym: "Golgi-derived vesicle uncoating" EXACT [] is_a: GO:0072319 ! vesicle uncoating relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048213 name: Golgi vesicle prefusion complex stabilization namespace: biological_process def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW [] synonym: "Golgi vesicle prefusion complex assembly" EXACT [] synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048214 name: regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion. is_a: GO:0031338 ! regulation of vesicle fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048210 ! Golgi vesicle fusion to target membrane relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048215 name: positive regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "activation of Golgi vesicle fusion to target membrane" NARROW [] synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW [] synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT [] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048216 name: negative regulation of Golgi vesicle fusion to target membrane namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT [] synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW [] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane [Term] id: GO:0048217 name: pectic matrix namespace: cellular_component def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jid, PMID:11554482] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048219 name: inter-Golgi cisterna vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "inter-Golgi cisterna transport" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0048222 name: glycoprotein network namespace: cellular_component def: "An extracellular matrix part that consists of cross-linked glycoproteins." [GOC:mah, PMID:18508691, PMID:7048321] synonym: "extensin" EXACT [] xref: Wikipedia:Extensin is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009530 ! primary cell wall [Term] id: GO:0048223 name: hemicellulose network namespace: cellular_component def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048224 name: lignin network namespace: cellular_component def: "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens." [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048225 name: suberin network namespace: cellular_component def: "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier." [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048226 name: Casparian strip namespace: cellular_component def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jid] xref: Wikipedia:Casparian_strip is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0048227 name: plasma membrane to endosome transport namespace: biological_process def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048228 name: obsolete actin cortical patch distribution namespace: biological_process def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jid] comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms. synonym: "actin cortical patch distribution" EXACT [] is_obsolete: true [Term] id: GO:0048229 name: gametophyte development namespace: biological_process def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jid, PO:0009004] synonym: "gametogenesis" BROAD [] xref: MIPS_funcat:41.03.01 xref: MIPS_funcat:43.02.17 is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0048232 name: male gamete generation namespace: biological_process def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] is_a: GO:0007276 ! gamete generation [Term] id: GO:0048235 name: pollen sperm cell differentiation namespace: biological_process alt_id: GO:0048234 def: "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [CL:0000366, GOC:jid, GOC:mtg_sensu] synonym: "male gamete generation" BROAD [] synonym: "male gametophyte sperm cell differentiation" EXACT [] synonym: "sperm cell differentiation" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048232 ! male gamete generation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0048236 name: plant-type sporogenesis namespace: biological_process def: "The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes." [GOC:tb] synonym: "plant spore formation" EXACT [] is_a: GO:0034293 ! sexual sporulation is_a: GO:0048869 ! cellular developmental process is_a: GO:0051321 ! meiotic cell cycle is_a: GO:1903046 ! meiotic cell cycle process [Term] id: GO:0048237 name: rough endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid] synonym: "RER lumen" EXACT [] synonym: "rough ER lumen" EXACT [] xref: NIF_Subcellular:sao1819509473 is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005791 ! rough endoplasmic reticulum relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0048238 name: smooth endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid] synonym: "SER lumen" EXACT [] synonym: "smooth ER lumen" EXACT [] xref: NIF_Subcellular:sao927884761 is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005790 ! smooth endoplasmic reticulum relationship: part_of GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0048239 name: negative regulation of DNA recombination at telomere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jid, PMID:9635193] synonym: "down regulation of telomeric recombination at telomere" EXACT [] synonym: "down-regulation of telomeric recombination at telomere" EXACT [] synonym: "downregulation of telomeric recombination at telomere" EXACT [] synonym: "inhibition of telomeric recombination at telomere" NARROW [] synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb] synonym: "suppression of telomeric recombination at telomere" EXACT [] is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0072695 ! regulation of DNA recombination at telomere [Term] id: GO:0048240 name: sperm capacitation namespace: biological_process def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818] comment: Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract. synonym: "sperm activation" RELATED [PMID:23180860] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0048241 name: epinephrine transport namespace: biological_process def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid] synonym: "adrenaline transport" EXACT [] is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0048242 name: epinephrine secretion namespace: biological_process def: "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid] synonym: "adrenaline secretion" EXACT [] is_a: GO:0048241 ! epinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048243 name: norepinephrine secretion namespace: biological_process def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] synonym: "noradrenaline secretion" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0048244 name: phytanoyl-CoA dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16065] synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18] synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18] xref: EC:1.14.11.18 xref: KEGG_REACTION:R05722 xref: MetaCyc:1.14.11.18-RXN xref: Reactome:R-HSA-389639 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2" xref: RHEA:16065 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0048245 name: eosinophil chemotaxis namespace: biological_process def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252] is_a: GO:0071621 ! granulocyte chemotaxis is_a: GO:0072677 ! eosinophil migration [Term] id: GO:0048246 name: macrophage chemotaxis namespace: biological_process def: "The movement of a macrophage in response to an external stimulus." [GOC:jid] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:1905517 ! macrophage migration [Term] id: GO:0048247 name: lymphocyte chemotaxis namespace: biological_process def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0072676 ! lymphocyte migration [Term] id: GO:0048248 name: CXCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a the CXCR3 chemokine receptor." [GOC:jid, PMID:10556837] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0048249 name: high-affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jid, PMID:8709965] synonym: "high affinity phosphate transmembrane transporter activity" EXACT [] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity [Term] id: GO:0048250 name: iron import into the mitochondrion namespace: biological_process alt_id: GO:1990925 def: "The process in which iron is transported from the cytosol, into the mitochondrial matrix." [GOC:jid, PMID:12006577] synonym: "mitochondrial iron cation transmembrane transport" EXACT [] synonym: "mitochondrial iron ion transmembrane transport" RELATED [] synonym: "mitochondrial iron ion transport" RELATED [] synonym: "mitochondrial iron transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: al creation_date: 2016-02-10T11:24:22Z [Term] id: GO:0048251 name: elastic fiber assembly namespace: biological_process def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] synonym: "elastic fibre assembly" EXACT [] synonym: "elastin fiber assembly" EXACT [GOC:BHF] synonym: "elastin fibre assembly" EXACT [GOC:BHF] is_a: GO:0085029 ! extracellular matrix assembly is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0048252 name: lauric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [GOC:jid, PMID:15555597] synonym: "lauric acid metabolism" EXACT [] synonym: "n-dodecanoic acid metabolic process" EXACT [] synonym: "n-dodecanoic acid metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] id: GO:0048254 name: snoRNA localization namespace: biological_process def: "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363] synonym: "establishment and maintenance of snoRNA localization" EXACT [] synonym: "small nucleolar RNA localization" EXACT [] synonym: "snoRNA localisation" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization [Term] id: GO:0048255 name: mRNA stabilization namespace: biological_process def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] is_a: GO:0043488 ! regulation of mRNA stability is_a: GO:0043489 ! RNA stabilization is_a: GO:1902373 ! negative regulation of mRNA catabolic process [Term] id: GO:0048256 name: flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0048257 name: 3'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319] synonym: "3' flap endonuclease activity" EXACT [] is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters is_a: GO:0048256 ! flap endonuclease activity [Term] id: GO:0048258 name: 3-ketoglucose-reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN] xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0048259 name: regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb] is_a: GO:0030100 ! regulation of endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006898 ! receptor-mediated endocytosis relationship: regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048260 name: positive regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] synonym: "activation of receptor mediated endocytosis" NARROW [] synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb] synonym: "stimulation of receptor mediated endocytosis" NARROW [] synonym: "up regulation of receptor mediated endocytosis" EXACT [] synonym: "up-regulation of receptor mediated endocytosis" EXACT [] synonym: "upregulation of receptor mediated endocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0048259 ! regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006898 ! receptor-mediated endocytosis relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048261 name: negative regulation of receptor-mediated endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators] synonym: "down regulation of receptor mediated endocytosis" EXACT [] synonym: "down-regulation of receptor mediated endocytosis" EXACT [] synonym: "downregulation of receptor mediated endocytosis" EXACT [] synonym: "inhibition of receptor mediated endocytosis" NARROW [] synonym: "negative regulation of receptor mediated endocytosis" EXACT [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0048259 ! regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006898 ! receptor-mediated endocytosis relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis [Term] id: GO:0048262 name: determination of dorsal/ventral asymmetry namespace: biological_process def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid] synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb] synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah] synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah] is_a: GO:0009855 ! determination of bilateral symmetry relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0048263 name: determination of dorsal identity namespace: biological_process def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jid] synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry [Term] id: GO:0048264 name: determination of ventral identity namespace: biological_process def: "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jid] synonym: "determination of abaxial identity" EXACT [] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry [Term] id: GO:0048265 name: response to pain namespace: biological_process alt_id: GO:0048267 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain] synonym: "physiological response to pain" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0048266 name: behavioral response to pain namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] synonym: "behavioural response to pain" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0048265 ! response to pain [Term] id: GO:0048268 name: clathrin coat assembly namespace: biological_process def: "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549] synonym: "clathrin cage assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0048269 name: methionine adenosyltransferase complex namespace: cellular_component def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jid, PMID:10644686] synonym: "MAT complex" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0048270 name: methionine adenosyltransferase regulator activity namespace: molecular_function def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jid, PMID:10644686] comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. synonym: "MAT regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0004478 ! methionine adenosyltransferase activity [Term] id: GO:0048273 name: mitogen-activated protein kinase p38 binding namespace: molecular_function def: "Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [GOC:curators, PMID:17827184] synonym: "MAPK p38 binding" EXACT [] is_a: GO:0051019 ! mitogen-activated protein kinase binding [Term] id: GO:0048275 name: N-terminal peptidyl-arginine acetylation namespace: biological_process def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354] xref: RESID:AA0354 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0048277 name: obsolete nonexocytotic vesicle docking namespace: biological_process def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jid] comment: This term was made obsolete because it violates the principle of positivity. synonym: "non-exocytotic vesicle docking" EXACT [] synonym: "nonexocytotic vesicle docking" EXACT [] is_obsolete: true replaced_by: GO:0048278 [Term] id: GO:0048278 name: vesicle docking namespace: biological_process def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid] synonym: "vesicle to membrane docking" EXACT [] is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0048279 name: vesicle fusion with endoplasmic reticulum namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jid] synonym: "vesicle fusion with ER" EXACT [] is_a: GO:0006906 ! vesicle fusion [Term] id: GO:0048280 name: vesicle fusion with Golgi apparatus namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0048281 name: inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010016 ! shoot system morphogenesis is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0048282 name: determinate inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jid, PMID:9553044] is_a: GO:0048281 ! inflorescence morphogenesis [Term] id: GO:0048283 name: indeterminate inflorescence morphogenesis namespace: biological_process def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jid] is_a: GO:0048281 ! inflorescence morphogenesis [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048286 name: lung alveolus development namespace: biological_process def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757] synonym: "alveolarization" EXACT [PMID:17911382] synonym: "alveologenesis" EXACT [GOC:17911382] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion intersection_of: GO:0000740 ! nuclear membrane fusion intersection_of: part_of GO:0000741 ! karyogamy relationship: part_of GO:0000741 ! karyogamy [Term] id: GO:0048289 name: isotype switching to IgE isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switch recombination to IgE isotypes" EXACT [] synonym: "class switching to IgE isotypes" EXACT [] synonym: "isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048290 name: isotype switching to IgA isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switching to IgA isotypes" EXACT [] synonym: "isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048291 name: isotype switching to IgG isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] synonym: "class switching to IgG isotypes" EXACT [] synonym: "isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048292 name: isotype switching to IgD isotypes namespace: biological_process def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms. synonym: "class switching to IgD isotypes" EXACT [] synonym: "isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045190 ! isotype switching [Term] id: GO:0048293 name: regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "regulation of class switching to IgE isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048289 ! isotype switching to IgE isotypes relationship: regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048294 name: negative regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgE isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "downregulation of isotype switching to IgE isotypes" EXACT [] synonym: "inhibition of isotype switching to IgE isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "negative regulation of class switching to IgE isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048295 name: positive regulation of isotype switching to IgE isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] synonym: "activation of isotype switching to IgE isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT [] synonym: "positive regulation of class switching to IgE isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT [] synonym: "stimulation of isotype switching to IgE isotypes" NARROW [] synonym: "up regulation of isotype switching to IgE isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgE isotypes" EXACT [] synonym: "upregulation of isotype switching to IgE isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048289 ! isotype switching to IgE isotypes relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes [Term] id: GO:0048296 name: regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "regulation of class switching to IgA isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048290 ! isotype switching to IgA isotypes relationship: regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048297 name: negative regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgA isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgA isotypes" EXACT [] synonym: "downregulation of isotype switching to IgA isotypes" EXACT [] synonym: "inhibition of isotype switching to IgA isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "negative regulation of class switching to IgA isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048298 name: positive regulation of isotype switching to IgA isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] synonym: "activation of isotype switching to IgA isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT [] synonym: "positive regulation of class switching to IgA isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT [] synonym: "stimulation of isotype switching to IgA isotypes" NARROW [] synonym: "up regulation of isotype switching to IgA isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgA isotypes" EXACT [] synonym: "upregulation of isotype switching to IgA isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048290 ! isotype switching to IgA isotypes relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes [Term] id: GO:0048299 name: regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "regulation of class switching to IgD isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048292 ! isotype switching to IgD isotypes relationship: regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048300 name: negative regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgD isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgD isotypes" EXACT [] synonym: "downregulation of isotype switching to IgD isotypes" EXACT [] synonym: "inhibition of isotype switching to IgD isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "negative regulation of class switching to IgD isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048301 name: positive regulation of isotype switching to IgD isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] synonym: "activation of isotype switching to IgD isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT [] synonym: "positive regulation of class switching to IgD isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT [] synonym: "stimulation of isotype switching to IgD isotypes" NARROW [] synonym: "up regulation of isotype switching to IgD isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgD isotypes" EXACT [] synonym: "upregulation of isotype switching to IgD isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048292 ! isotype switching to IgD isotypes relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes [Term] id: GO:0048302 name: regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "regulation of class switching to IgG isotypes" EXACT [] synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045191 ! regulation of isotype switching intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048291 ! isotype switching to IgG isotypes relationship: regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048303 name: negative regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "down regulation of isotype switching to IgG isotypes" EXACT [] synonym: "down-regulation of isotype switching to IgG isotypes" EXACT [] synonym: "downregulation of isotype switching to IgG isotypes" EXACT [] synonym: "inhibition of isotype switching to IgG isotypes" NARROW [] synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "negative regulation of class switching to IgG isotypes" EXACT [] synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT [] is_a: GO:0045829 ! negative regulation of isotype switching is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048304 name: positive regulation of isotype switching to IgG isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] synonym: "activation of isotype switching to IgG isotypes" NARROW [] synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT [] synonym: "positive regulation of class switching to IgG isotypes" EXACT [] synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT [] synonym: "stimulation of isotype switching to IgG isotypes" NARROW [] synonym: "up regulation of isotype switching to IgG isotypes" EXACT [] synonym: "up-regulation of isotype switching to IgG isotypes" EXACT [] synonym: "upregulation of isotype switching to IgG isotypes" EXACT [] is_a: GO:0045830 ! positive regulation of isotype switching is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048291 ! isotype switching to IgG isotypes relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes [Term] id: GO:0048305 name: immunoglobulin secretion namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin." [GOC:add, ISBN:0781735149, PMID:9185563] synonym: "antibody secretion" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0048306 name: calcium-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jid, PMID:10485905] is_a: GO:0005515 ! protein binding intersection_of: GO:0005515 ! protein binding intersection_of: has_part GO:0005509 ! calcium ion binding relationship: has_part GO:0005509 ! calcium ion binding [Term] id: GO:0048307 name: ferredoxin-nitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jid] synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1] xref: EC:1.7.7.1 xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor is_a: GO:0098809 ! nitrite reductase activity [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048309 name: endoplasmic reticulum inheritance namespace: biological_process def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jid] synonym: "ER inheritance" EXACT [] is_a: GO:0007029 ! endoplasmic reticulum organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048310 name: nucleus inheritance namespace: biological_process def: "The partitioning of nuclei between daughter cells at cell division." [GOC:jid] synonym: "cell nucleus inheritance" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048311 name: mitochondrion distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] synonym: "distribution of mitochondria" EXACT [] synonym: "mitochondrial distribution" EXACT [] synonym: "positioning of mitochondria" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0051646 ! mitochondrion localization [Term] id: GO:0048312 name: intracellular distribution of mitochondria namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] synonym: "mitochondria positioning within cell" EXACT [] synonym: "mitochondrion positioning within cell" EXACT [] is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0048313 name: Golgi inheritance namespace: biological_process def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi partitioning" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0048314 name: embryo sac morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jid, GOC:mtg_plant, http://www.bio.uu.nl] synonym: "female gametophyte morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0048315 name: conidium formation namespace: biological_process def: "The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, ISBN:0963117211, PMID:2524423, PMID:9529886] synonym: "conidia biosynthesis" RELATED [] synonym: "conidia formation" EXACT [] xref: MIPS_funcat:43.01.03.07 is_a: GO:0030436 ! asexual sporulation relationship: part_of GO:0061794 ! conidium development [Term] id: GO:0048316 name: seed development namespace: biological_process def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jid, PO:0009010] xref: MIPS_funcat:47.02.01.05 is_a: GO:0009791 ! post-embryonic development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0048317 name: seed morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the seed are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0048316 ! seed development [Term] id: GO:0048318 name: axial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048319 name: axial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048318 ! axial mesoderm development [Term] id: GO:0048320 name: axial mesoderm formation namespace: biological_process def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048319 ! axial mesoderm morphogenesis [Term] id: GO:0048321 name: axial mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh] synonym: "axial mesoderm cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048320 ! axial mesoderm formation [Term] id: GO:0048322 name: axial mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh] synonym: "axial mesoderm cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048321 ! axial mesodermal cell differentiation [Term] id: GO:0048323 name: axial mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] synonym: "axial mesoderm cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment [Term] id: GO:0048324 name: regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048323 ! axial mesodermal cell fate determination relationship: regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048325 name: negative regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of axial mesodermal cell fate determination" EXACT [] synonym: "down-regulation of axial mesodermal cell fate determination" EXACT [] synonym: "downregulation of axial mesodermal cell fate determination" EXACT [] synonym: "inhibition of axial mesodermal cell fate determination" NARROW [] is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048326 name: positive regulation of axial mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] synonym: "activation of axial mesodermal cell fate determination" NARROW [] synonym: "stimulation of axial mesodermal cell fate determination" NARROW [] synonym: "up regulation of axial mesodermal cell fate determination" EXACT [] synonym: "up-regulation of axial mesodermal cell fate determination" EXACT [] synonym: "upregulation of axial mesodermal cell fate determination" EXACT [] is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048323 ! axial mesodermal cell fate determination relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination [Term] id: GO:0048327 name: axial mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] synonym: "axial mesoderm cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment [Term] id: GO:0048328 name: regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048327 ! axial mesodermal cell fate specification relationship: regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048329 name: negative regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of axial mesodermal cell fate specification" EXACT [] synonym: "down-regulation of axial mesodermal cell fate specification" EXACT [] synonym: "downregulation of axial mesodermal cell fate specification" EXACT [] synonym: "inhibition of axial mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048330 name: positive regulation of axial mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] synonym: "activation of axial mesodermal cell fate specification" NARROW [] synonym: "stimulation of axial mesodermal cell fate specification" NARROW [] synonym: "up regulation of axial mesodermal cell fate specification" EXACT [] synonym: "up-regulation of axial mesodermal cell fate specification" EXACT [] synonym: "upregulation of axial mesodermal cell fate specification" EXACT [] is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048327 ! axial mesodermal cell fate specification relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification [Term] id: GO:0048331 name: axial mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "axial mesoderm structural organisation" EXACT [] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048319 ! axial mesoderm morphogenesis [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048333 name: mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] synonym: "mesoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0048334 name: regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] is_a: GO:1905770 ! regulation of mesodermal cell differentiation is_a: GO:1905933 ! regulation of cell fate determination is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007500 ! mesodermal cell fate determination relationship: regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048335 name: negative regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of mesodermal cell fate determination" EXACT [] synonym: "down-regulation of mesodermal cell fate determination" EXACT [] synonym: "downregulation of mesodermal cell fate determination" EXACT [] synonym: "inhibition of mesodermal cell fate determination" NARROW [] is_a: GO:0048334 ! regulation of mesodermal cell fate determination is_a: GO:1905771 ! negative regulation of mesodermal cell differentiation is_a: GO:1905934 ! negative regulation of cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007500 ! mesodermal cell fate determination relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048336 name: positive regulation of mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] synonym: "activation of mesodermal cell fate determination" NARROW [] synonym: "stimulation of mesodermal cell fate determination" NARROW [] synonym: "up regulation of mesodermal cell fate determination" EXACT [] synonym: "up-regulation of mesodermal cell fate determination" EXACT [] synonym: "upregulation of mesodermal cell fate determination" EXACT [] is_a: GO:0048334 ! regulation of mesodermal cell fate determination is_a: GO:1905772 ! positive regulation of mesodermal cell differentiation is_a: GO:1905935 ! positive regulation of cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007500 ! mesodermal cell fate determination relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination [Term] id: GO:0048337 name: positive regulation of mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh] synonym: "activation of mesodermal cell fate specification" NARROW [] synonym: "stimulation of mesodermal cell fate specification" NARROW [] synonym: "up regulation of mesodermal cell fate specification" EXACT [] synonym: "up-regulation of mesodermal cell fate specification" EXACT [] synonym: "upregulation of mesodermal cell fate specification" EXACT [] is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:0042661 ! regulation of mesodermal cell fate specification is_a: GO:1905772 ! positive regulation of mesodermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007501 ! mesodermal cell fate specification relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification [Term] id: GO:0048338 name: mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "mesoderm structural organisation" EXACT [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0048339 name: paraxial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development [Term] id: GO:0048340 name: paraxial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0048339 ! paraxial mesoderm development [Term] id: GO:0048341 name: paraxial mesoderm formation namespace: biological_process def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis [Term] id: GO:0048342 name: paraxial mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048341 ! paraxial mesoderm formation [Term] id: GO:0048343 name: paraxial mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation [Term] id: GO:0048344 name: paraxial mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment [Term] id: GO:0048345 name: regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048344 ! paraxial mesodermal cell fate determination relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048346 name: positive regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] synonym: "activation of paraxial mesodermal cell fate determination" NARROW [] synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW [] synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048347 name: negative regulation of paraxial mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT [] synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination [Term] id: GO:0048348 name: paraxial mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment [Term] id: GO:0048349 name: regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048348 ! paraxial mesodermal cell fate specification relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048350 name: positive regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] synonym: "activation of paraxial mesodermal cell fate specification" NARROW [] synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW [] synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048351 name: negative regulation of paraxial mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT [] synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification [Term] id: GO:0048352 name: paraxial mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "paraxial mesoderm structural organisation" EXACT [] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis [Term] id: GO:0048353 name: primary endosperm nucleus namespace: cellular_component def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208] is_a: GO:0005634 ! nucleus [Term] id: GO:0048354 name: mucilage biosynthetic process involved in seed coat development namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] synonym: "mucilage anabolism during seed coat development" EXACT [] synonym: "mucilage biosynthetic process during seed coat development" RELATED [GOC:dph, GOC:tb] synonym: "mucilage formation during seed coat development" EXACT [] synonym: "mucilage synthesis during seed coat development" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process is_a: GO:0048359 ! mucilage metabolic process involved in seed coat development intersection_of: GO:0010192 ! mucilage biosynthetic process intersection_of: part_of GO:0010214 ! seed coat development [Term] id: GO:0048355 name: root cap mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root cap mucilage anabolism" EXACT [] synonym: "root cap mucilage biosynthesis" EXACT [] synonym: "root cap mucilage formation" EXACT [] synonym: "root cap mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048360 ! root cap mucilage metabolic process [Term] id: GO:0048356 name: root epithelial mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root epithelial mucilage anabolism" EXACT [] synonym: "root epithelial mucilage biosynthesis" EXACT [] synonym: "root epithelial mucilage formation" EXACT [] synonym: "root epithelial mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process [Term] id: GO:0048357 name: pedicel mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jid] synonym: "pedicel mucilage anabolism" EXACT [] synonym: "pedicel mucilage biosynthesis" EXACT [] synonym: "pedicel mucilage formation" EXACT [] synonym: "pedicel mucilage synthesis" EXACT [] is_a: GO:0010192 ! mucilage biosynthetic process relationship: part_of GO:0048362 ! pedicel mucilage metabolic process [Term] id: GO:0048358 name: mucilage pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jid] synonym: "mucilage pectin anabolism" EXACT [] synonym: "mucilage pectin biosynthesis" EXACT [] synonym: "mucilage pectin formation" EXACT [] synonym: "mucilage pectin synthesis" EXACT [] is_a: GO:0045489 ! pectin biosynthetic process is_a: GO:0048363 ! mucilage pectin metabolic process relationship: part_of GO:0010192 ! mucilage biosynthetic process [Term] id: GO:0048359 name: mucilage metabolic process involved in seed coat development namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] synonym: "mucilage metabolic process during seed coat development" RELATED [GOC:dph, GOC:tb] synonym: "mucilage metabolism during seed coat development" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0022414 ! reproductive process intersection_of: GO:0010191 ! mucilage metabolic process intersection_of: part_of GO:0010214 ! seed coat development relationship: part_of GO:0010214 ! seed coat development [Term] id: GO:0048360 name: root cap mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root cap mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048361 name: root epithelial mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] synonym: "root epithelial mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048362 name: pedicel mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jid] synonym: "pedicel mucilage metabolism" EXACT [] is_a: GO:0010191 ! mucilage metabolic process [Term] id: GO:0048363 name: mucilage pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jid] synonym: "mucilage pectin metabolism" EXACT [] is_a: GO:0045488 ! pectin metabolic process relationship: part_of GO:0010191 ! mucilage metabolic process [Term] id: GO:0048364 name: root development namespace: biological_process def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jid, PO:0009005] xref: MIPS_funcat:47.02.02 is_a: GO:0099402 ! plant organ development relationship: part_of GO:0022622 ! root system development [Term] id: GO:0048365 name: Rac GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775] is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0048366 name: leaf development namespace: biological_process def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators] xref: MIPS_funcat:47.02.01.02 is_a: GO:0048827 ! phyllome development [Term] id: GO:0048367 name: shoot system development namespace: biological_process alt_id: GO:0022621 def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:go_curators] synonym: "shoot development" EXACT [] xref: MIPS_funcat:47.02.01 is_a: GO:0048731 ! system development [Term] id: GO:0048368 name: lateral mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] synonym: "lateral plate mesoderm development" EXACT [] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development [Term] id: GO:0048369 name: lateral mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] synonym: "lateral plate mesoderm morphogenesis" EXACT [] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0048368 ! lateral mesoderm development [Term] id: GO:0048370 name: lateral mesoderm formation namespace: biological_process def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] synonym: "lateral plate mesoderm biosynthesis" EXACT [] synonym: "lateral plate mesoderm formation" EXACT [] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis [Term] id: GO:0048371 name: lateral mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jid] synonym: "lateral mesoderm cell differentiation" EXACT [] synonym: "lateral plate mesoderm cell differentiation" EXACT [] synonym: "lateral plate mesodermal cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048370 ! lateral mesoderm formation [Term] id: GO:0048372 name: lateral mesodermal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a lateral mesoderm cell." [GOC:jid] synonym: "lateral mesoderm cell fate commitment" EXACT [] synonym: "lateral plate mesoderm cell fate commitment" EXACT [] synonym: "lateral plate mesodermal cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation [Term] id: GO:0048373 name: lateral mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jid] synonym: "lateral mesoderm cell fate determination" EXACT [] synonym: "lateral plate mesoderm cell fate determination" EXACT [] synonym: "lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment [Term] id: GO:0048374 name: regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "regulation of lateral mesoderm cell fate determination" EXACT [] synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT [] synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0048334 ! regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048373 ! lateral mesodermal cell fate determination relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048375 name: negative regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "down regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "downregulation of lateral mesodermal cell fate determination" EXACT [] synonym: "inhibition of lateral mesodermal cell fate determination" NARROW [] synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048376 name: positive regulation of lateral mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] synonym: "activation of lateral mesodermal cell fate determination" NARROW [] synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT [] synonym: "stimulation of lateral mesodermal cell fate determination" NARROW [] synonym: "up regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT [] synonym: "upregulation of lateral mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination [Term] id: GO:0048377 name: lateral mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jid] synonym: "lateral mesoderm cell fate specification" EXACT [] synonym: "lateral plate mesoderm cell fate specification" EXACT [] synonym: "lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment [Term] id: GO:0048378 name: regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0042661 ! regulation of mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048377 ! lateral mesodermal cell fate specification relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048379 name: positive regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "activation of lateral mesodermal cell fate specification" NARROW [] synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT [] synonym: "stimulation of lateral mesodermal cell fate specification" NARROW [] synonym: "up regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "upregulation of lateral mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048380 name: negative regulation of lateral mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] synonym: "down regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT [] synonym: "downregulation of lateral mesodermal cell fate specification" EXACT [] synonym: "inhibition of lateral mesodermal cell fate specification" NARROW [] synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification [Term] id: GO:0048381 name: lateral mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "lateral mesoderm structural organisation" EXACT [] synonym: "lateral plate mesoderm structural organization" EXACT [] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis [Term] id: GO:0048382 name: mesendoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007492 ! endoderm development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048383 name: mesectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jid] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007398 ! ectoderm development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0048384 name: retinoic acid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh] synonym: "RAR signaling pathway" EXACT [] synonym: "retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0048385 name: regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "regulation of RAR signaling pathway" EXACT [] synonym: "regulation of retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048384 ! retinoic acid receptor signaling pathway relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048386 name: positive regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "activation of retinoic acid receptor signaling pathway" NARROW [] synonym: "positive regulation of RAR signaling pathway" EXACT [] synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT [] synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW [] synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048387 name: negative regulation of retinoic acid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT [] synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW [] synonym: "negative regulation of RAR signaling pathway" EXACT [] synonym: "negative regulation of RAR signalling pathway" EXACT [] synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0048388 name: endosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction relationship: part_of GO:0007032 ! endosome organization [Term] id: GO:0048389 name: intermediate mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] is_a: GO:0007498 ! mesoderm development [Term] id: GO:0048390 name: intermediate mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis relationship: part_of GO:0048389 ! intermediate mesoderm development [Term] id: GO:0048391 name: intermediate mesoderm formation namespace: biological_process def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] is_a: GO:0001707 ! mesoderm formation relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis [Term] id: GO:0048392 name: intermediate mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh] synonym: "intermediate mesoderm cell differentiation" EXACT [] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0048391 ! intermediate mesoderm formation [Term] id: GO:0048393 name: intermediate mesodermal cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh] synonym: "intermediate mesoderm cell fate commitment" EXACT [] is_a: GO:0001710 ! mesodermal cell fate commitment relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation [Term] id: GO:0048394 name: intermediate mesodermal cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] synonym: "intermediate mesoderm cell fate determination" EXACT [] is_a: GO:0007500 ! mesodermal cell fate determination relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment [Term] id: GO:0048395 name: regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] is_a: GO:0048334 ! regulation of mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048394 ! intermediate mesodermal cell fate determination relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048396 name: negative regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW [] is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048397 name: positive regulation of intermediate mesodermal cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] synonym: "activation of intermediate mesodermal cell fate determination" NARROW [] synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW [] synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT [] synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT [] is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination [Term] id: GO:0048398 name: intermediate mesodermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] synonym: "intermediate mesoderm cell fate specification" EXACT [] is_a: GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment [Term] id: GO:0048399 name: regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] is_a: GO:0042661 ! regulation of mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048398 ! intermediate mesodermal cell fate specification relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048400 name: positive regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] synonym: "activation of intermediate mesodermal cell fate specification" NARROW [] synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW [] synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT [] is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048401 name: negative regulation of intermediate mesodermal cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT [] synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW [] is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification [Term] id: GO:0048402 name: intermediate mesoderm structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] synonym: "intermediate mesoderm structural organisation" EXACT [] is_a: GO:0048338 ! mesoderm structural organization relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis [Term] id: GO:0048403 name: brain-derived neurotrophic factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with brain-derived neurotrophic factor." [GOC:dgh] synonym: "BDNF binding" EXACT [] synonym: "neurotrophin TRKB receptor activity" RELATED [] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048406 name: nerve growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with nerve growth factor (NGF)." [GOC:dgh] synonym: "beta-nerve growth factor binding" EXACT [PR:000011194] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "NGF binding" EXACT [PR:000011194] is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0048407 name: platelet-derived growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with platelet-derived growth factor." [GOC:dgh] synonym: "PDGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0048408 name: epidermal growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with epidermal growth factor." [GOC:dgh] synonym: "EGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0048437 name: floral organ development namespace: biological_process alt_id: GO:0048433 def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators, GOC:PO_curators, PO:0025395] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0099402 ! plant organ development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048438 name: floral whorl development namespace: biological_process alt_id: GO:0048413 def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:PO_curators, GOC:tb, PO:0025023] comment: Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms. synonym: "collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048439 name: flower morphogenesis namespace: biological_process alt_id: GO:0048411 def: "The process in which the anatomical structures of the flower are generated and organized." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010016 ! shoot system morphogenesis is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048440 name: carpel development namespace: biological_process alt_id: GO:0048429 def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators] xref: MIPS_funcat:47.02.01.03.04 is_a: GO:0048437 ! floral organ development is_a: GO:0048827 ! phyllome development relationship: part_of GO:0048467 ! gynoecium development [Term] id: GO:0048441 name: petal development namespace: biological_process alt_id: GO:0048417 def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators] xref: MIPS_funcat:47.02.01.03.02 is_a: GO:0048437 ! floral organ development is_a: GO:0048827 ! phyllome development relationship: part_of GO:0048465 ! corolla development [Term] id: GO:0048442 name: sepal development namespace: biological_process alt_id: GO:0048421 def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators] xref: MIPS_funcat:47.02.01.03.01 is_a: GO:0048437 ! floral organ development is_a: GO:0048827 ! phyllome development relationship: part_of GO:0048464 ! flower calyx development [Term] id: GO:0048443 name: stamen development namespace: biological_process alt_id: GO:0048425 def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048437 ! floral organ development is_a: GO:0048827 ! phyllome development relationship: part_of GO:0048466 ! androecium development [Term] id: GO:0048444 name: floral organ morphogenesis namespace: biological_process alt_id: GO:0048434 def: "The process in which the anatomical structures of the floral organ are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025395] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090697 ! post-embryonic plant organ morphogenesis relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0048445 name: carpel morphogenesis namespace: biological_process alt_id: GO:0048430 def: "The process in which the anatomical structures of the carpel are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048446 name: petal morphogenesis namespace: biological_process alt_id: GO:0048418 def: "The process in which the anatomical structures of the petal are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048441 ! petal development [Term] id: GO:0048447 name: sepal morphogenesis namespace: biological_process alt_id: GO:0048422 def: "The process in which the anatomical structures of the sepal are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048442 ! sepal development [Term] id: GO:0048448 name: stamen morphogenesis namespace: biological_process alt_id: GO:0048426 def: "The process in which the anatomical structures of the stamen are generated and organized." [GOC:go_curators] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048443 ! stamen development [Term] id: GO:0048449 name: floral organ formation namespace: biological_process alt_id: GO:0048436 def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025395] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0048444 ! floral organ morphogenesis [Term] id: GO:0048450 name: floral organ structural organization namespace: biological_process alt_id: GO:0048435 def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025395] synonym: "floral organ structural organisation" EXACT [] is_a: GO:0048444 ! floral organ morphogenesis is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048461 ! flower structural organization [Term] id: GO:0048451 name: petal formation namespace: biological_process alt_id: GO:0048419 def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048452 name: petal structural organization namespace: biological_process alt_id: GO:0048420 def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "petal structural organisation" EXACT [] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048453 name: sepal formation namespace: biological_process alt_id: GO:0048423 def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048447 ! sepal morphogenesis [Term] id: GO:0048454 name: sepal structural organization namespace: biological_process alt_id: GO:0048424 def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "sepal structural organisation" EXACT [] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048447 ! sepal morphogenesis [Term] id: GO:0048455 name: stamen formation namespace: biological_process alt_id: GO:0048427 def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048448 ! stamen morphogenesis [Term] id: GO:0048456 name: stamen structural organization namespace: biological_process alt_id: GO:0048428 def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "stamen structural organisation" EXACT [] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048448 ! stamen morphogenesis [Term] id: GO:0048457 name: floral whorl morphogenesis namespace: biological_process alt_id: GO:0048414 def: "The process in which the anatomical structures of the floral whorl are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025023] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0048438 ! floral whorl development relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048458 name: floral whorl formation namespace: biological_process alt_id: GO:0048415 def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025023] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048457 ! floral whorl morphogenesis [Term] id: GO:0048459 name: floral whorl structural organization namespace: biological_process alt_id: GO:0048416 def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025023] synonym: "floral whorl structural organisation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048457 ! floral whorl morphogenesis relationship: part_of GO:0048461 ! flower structural organization [Term] id: GO:0048460 name: flower formation namespace: biological_process alt_id: GO:0048410 def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048461 name: flower structural organization namespace: biological_process alt_id: GO:0048412 def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "flower structural organisation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048462 name: carpel formation namespace: biological_process alt_id: GO:0048431 def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] is_a: GO:0048449 ! floral organ formation relationship: part_of GO:0048445 ! carpel morphogenesis [Term] id: GO:0048463 name: carpel structural organization namespace: biological_process alt_id: GO:0048432 def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] synonym: "carpel structural organisation" EXACT [] is_a: GO:0048450 ! floral organ structural organization relationship: part_of GO:0048445 ! carpel morphogenesis [Term] id: GO:0048464 name: flower calyx development namespace: biological_process def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048465 name: corolla development namespace: biological_process def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048466 name: androecium development namespace: biological_process def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048467 name: gynoecium development namespace: biological_process def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, PO:0008062] synonym: "pistil development" EXACT [] is_a: GO:0048438 ! floral whorl development [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0021700 ! developmental maturation is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048471 name: perinuclear region of cytoplasm namespace: cellular_component def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0048472 name: threonine-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2)." [EC:4.1.1.81, RHEA:11492] synonym: "CobD" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81] synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81] synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT [] xref: EC:4.1.1.81 xref: KEGG_REACTION:R06530 xref: MetaCyc:4.1.1.81-RXN xref: RHEA:11492 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0048473 name: D-methionine transport namespace: biological_process def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620] is_a: GO:0015821 ! methionine transport is_a: GO:0042940 ! D-amino acid transport [Term] id: GO:0048474 name: D-methionine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] synonym: "D-methionine transporter activity" BROAD [] is_a: GO:0042943 ! D-amino acid transmembrane transporter activity is_a: GO:0043865 ! methionine transmembrane transporter activity relationship: part_of GO:0048473 ! D-methionine transport [Term] id: GO:0048475 name: coated membrane namespace: cellular_component def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] is_a: GO:0016020 ! membrane [Term] id: GO:0048476 name: Holliday junction resolvase complex namespace: cellular_component def: "An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758] subset: goslim_pir synonym: "Mus81-Eme1 complex" NARROW [] synonym: "Mus81-Eme1 holliday resolvase complex" NARROW [] synonym: "Mus81-Eme2 complex" NARROW [] synonym: "Mus81-Eme2 holliday resolvase complex" NARROW [] synonym: "resolvasome" EXACT [PMID:11207366] is_a: GO:1905347 ! endodeoxyribonuclease complex [Term] id: GO:0048477 name: oogenesis namespace: biological_process alt_id: GO:0009993 alt_id: GO:0048157 def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation [Term] id: GO:0048478 name: replication fork protection namespace: biological_process def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029] synonym: "replication fork maintenance" BROAD [] synonym: "replication fork stabilization" BROAD [] is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication [Term] id: GO:0048479 name: style development namespace: biological_process def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jid, PO:0009074] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048480 name: stigma development namespace: biological_process def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jid, PO:0009073] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048440 ! carpel development [Term] id: GO:0048481 name: plant ovule development namespace: biological_process def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0099402 ! plant organ development relationship: part_of GO:0035670 ! plant-type ovary development [Term] id: GO:0048482 name: plant ovule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090698 ! post-embryonic plant morphogenesis is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0048445 ! carpel morphogenesis relationship: part_of GO:0048481 ! plant ovule development [Term] id: GO:0048483 name: autonomic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0048484 name: enteric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048485 name: sympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048486 name: parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development relationship: part_of GO:0048483 ! autonomic nervous system development [Term] id: GO:0048487 name: beta-tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin." [GOC:krc] synonym: "beta tubulin binding" EXACT [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0048488 name: synaptic vesicle endocytosis namespace: biological_process alt_id: GO:0008099 def: "A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111] comment: Changed parent as requested in https://github.com/geneontology/synapse/issues/230 subset: goslim_synapse synonym: "synaptic vesicle retrieval" RELATED [] is_a: GO:0140238 ! presynaptic endocytosis relationship: part_of GO:0036465 ! synaptic vesicle recycling [Term] id: GO:0048489 name: synaptic vesicle transport namespace: biological_process alt_id: GO:0016181 def: "The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr] subset: goslim_synapse synonym: "synaptic vesicle fission" RELATED [] synonym: "synaptic vesicle fusion" RELATED [] synonym: "synaptic vesicle trafficking" RELATED [PMID:15217342] is_a: GO:0006810 ! transport is_a: GO:0051650 ! establishment of vesicle localization is_a: GO:0097479 ! synaptic vesicle localization [Term] id: GO:0048490 name: anterograde synaptic vesicle transport namespace: biological_process def: "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg] subset: goslim_synapse synonym: "anterograde axonal transport of synaptic vesicle" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0099517 ! synaptic vesicle transport along microtubule [Term] id: GO:0048491 name: retrograde synaptic vesicle transport namespace: biological_process def: "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body." [GOC:jid, GOC:lmg, PMID:24762653] subset: goslim_synapse synonym: "retrograde axonal transport of synaptic vesicle" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0099517 ! synaptic vesicle transport along microtubule [Term] id: GO:0048492 name: ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg] subset: goslim_pir synonym: "RubisCO complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0048493 name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT [] synonym: "ribulose bisphosphate carboxylase complex" BROAD [] synonym: "RubisCO complex" BROAD [] is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: part_of GO:0030075 ! bacterial thylakoid relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0048494 name: chromatophore ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] synonym: "RubisCO complex" BROAD [] is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: part_of GO:0042716 ! plasma membrane-derived chromatophore relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0048495 name: Roundabout binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527] synonym: "Roundabout receptor binding" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0048496 name: maintenance of animal organ identity namespace: biological_process def: "The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0048497 name: maintenance of floral organ identity namespace: biological_process def: "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:PO_curators, GOC:tair_curators, PMID:9090883, PO:0025395] is_a: GO:0022414 ! reproductive process is_a: GO:0090700 ! maintenance of plant organ identity relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0048498 name: establishment of petal orientation namespace: biological_process def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040] is_a: GO:0048559 ! establishment of floral organ orientation relationship: part_of GO:0048446 ! petal morphogenesis [Term] id: GO:0048499 name: synaptic vesicle membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806] synonym: "SLMV biogenesis" NARROW [] synonym: "synaptic vesicle membrane organisation" EXACT [] synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0048500 name: signal recognition particle namespace: cellular_component def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] subset: goslim_metagenomics subset: goslim_pir xref: Wikipedia:Signal_recognition_particle is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0048501 name: signal recognition particle, plasma membrane targeting namespace: cellular_component def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu] is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0048502 name: ATPase-coupled thiamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015619 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)." [PMID:9535878, TC:3.A.1.19.1] synonym: "ATP-dependent thiamine transmembrane transporter activity" EXACT [] synonym: "thiamin pyrophosphate ABC transporter" NARROW [] synonym: "thiamin pyrophosphate porter activity" BROAD [] synonym: "thiamin pyrophosphate transporting ATPase activity" RELATED [] synonym: "thiamin-transporting ATPase activity" EXACT [] synonym: "thiamine ABC transporter" NARROW [] synonym: "thiamine pyrophosphate-transporting ATPase activity" RELATED [] synonym: "thiamine-transporting ATPase activity" EXACT [] synonym: "TPP transporting ATPase activity" RELATED [] xref: RHEA:29811 is_a: GO:0015234 ! thiamine transmembrane transporter activity is_a: GO:0140394 ! ATPase-coupled azole transmembrane transporter activity [Term] id: GO:0048503 name: obsolete GPI anchor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors. synonym: "glycosylphosphatidylinositol binding" EXACT [] synonym: "GPI anchor binding" EXACT [] is_obsolete: true [Term] id: GO:0048504 name: regulation of timing of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of organ biosynthesis" RELATED [] synonym: "timing of organ formation" RELATED [] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:0040034 ! regulation of development, heterochronic [Term] id: GO:0048505 name: regulation of timing of cell differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of cell differentiation" RELATED [] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0045595 ! regulation of cell differentiation [Term] id: GO:0048506 name: regulation of timing of meristematic phase transition namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jid, GOC:tb] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0048509 ! regulation of meristem development [Term] id: GO:0048507 name: meristem development namespace: biological_process def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] xref: MIPS_funcat:45.02.01 is_a: GO:0009888 ! tissue development [Term] id: GO:0048508 name: embryonic meristem development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048507 ! meristem development relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0048509 name: regulation of meristem development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048507 ! meristem development relationship: regulates GO:0048507 ! meristem development [Term] id: GO:0048510 name: regulation of timing of transition from vegetative to reproductive phase namespace: biological_process def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jid, PMID:8974397] is_a: GO:0048506 ! regulation of timing of meristematic phase transition [Term] id: GO:0048511 name: rhythmic process namespace: biological_process def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] subset: goslim_pir synonym: "rhythm" RELATED [] xref: MIPS_funcat:34.11.11 is_a: GO:0008150 ! biological_process [Term] id: GO:0048512 name: circadian behavior namespace: biological_process def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] synonym: "circadian rhythm behavior" EXACT [] is_a: GO:0007622 ! rhythmic behavior is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0048515 name: spermatid differentiation namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] synonym: "spermatid cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0048516 name: obsolete trichome initiation (sensu Magnoliophyta) namespace: biological_process def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] comment: This term was made obsolete because more appropriate terms were created. synonym: "trichome initiation (sensu Magnoliophyta)" EXACT [] is_obsolete: true consider: GO:0048629 [Term] id: GO:0048517 name: obsolete positive regulation of trichome initiation (sensu Magnoliophyta) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] comment: This term was made obsolete because more appropriate terms were created. synonym: "positive regulation of trichome initiation (sensu Magnoliophyta)" EXACT [] is_obsolete: true consider: GO:0048629 [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008150 ! biological_process relationship: positively_regulates GO:0008150 ! biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008150 ! biological_process relationship: negatively_regulates GO:0008150 ! biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007610 ! behavior relationship: positively_regulates GO:0007610 ! behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007610 ! behavior relationship: negatively_regulates GO:0007610 ! behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009987 ! cellular process relationship: positively_regulates GO:0009987 ! cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009987 ! cellular process relationship: negatively_regulates GO:0009987 ! cellular process [Term] id: GO:0048524 name: positive regulation of viral process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl] synonym: "activation of viral life cycle" NARROW [] synonym: "positive regulation of viral life cycle" NARROW [GOC:tb] synonym: "positive regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] synonym: "stimulation of viral life cycle" NARROW [] synonym: "up regulation of viral life cycle" NARROW [] synonym: "up-regulation of viral life cycle" NARROW [] synonym: "upregulation of viral life cycle" NARROW [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016032 ! viral process relationship: positively_regulates GO:0016032 ! viral process [Term] id: GO:0048525 name: negative regulation of viral process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl] synonym: "down regulation of viral life cycle" NARROW [] synonym: "down-regulation of viral life cycle" NARROW [] synonym: "downregulation of viral life cycle" NARROW [] synonym: "inhibition of viral life cycle" NARROW [] synonym: "negative regulation of viral life cycle" NARROW [GOC:tb] synonym: "negative regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016032 ! viral process relationship: negatively_regulates GO:0016032 ! viral process [Term] id: GO:0048526 name: imaginal disc-derived wing expansion namespace: biological_process def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] synonym: "wing expansion" EXACT [] synonym: "wing inflation" EXACT [] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0048527 name: lateral root development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb] is_a: GO:0048528 ! post-embryonic root development [Term] id: GO:0048528 name: post-embryonic root development namespace: biological_process def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0048364 ! root development is_a: GO:0090696 ! post-embryonic plant organ development [Term] id: GO:0048529 name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity namespace: molecular_function def: "Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81] synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81] synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81] xref: EC:1.14.13.81 xref: RHEA:25089 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0048530 name: fruit morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant." [GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0048531 name: beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958] is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0048532 name: anatomical structure arrangement namespace: biological_process def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators] synonym: "anatomical structure organization" BROAD [] synonym: "anatomical structure structural organization" EXACT [] synonym: "organization of an anatomical structure" EXACT [] synonym: "structural organization" EXACT [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048533 name: sporocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators] synonym: "sporocyte development" NARROW [] synonym: "sporocyte morphogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hemopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0048535 name: lymph node development namespace: biological_process def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X, ISBN:0781735149] synonym: "lymph gland development" BROAD [] is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0048536 name: spleen development namespace: biological_process def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] xref: MIPS_funcat:47.03.05.02 is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0048537 name: mucosal-associated lymphoid tissue development namespace: biological_process def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] synonym: "BALT development" NARROW [] synonym: "bronchial-associated lymphoid tissue development" NARROW [] synonym: "GALT development" NARROW [] synonym: "gut-associated lymphoid tissue development" NARROW [] synonym: "NALT development" NARROW [] synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW [] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0048538 name: thymus development namespace: biological_process def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149] comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. xref: MIPS_funcat:47.03.05.01 is_a: GO:0048534 ! hematopoietic or lymphoid organ development is_a: GO:0048732 ! gland development [Term] id: GO:0048539 name: bone marrow development namespace: biological_process def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development relationship: part_of GO:0060348 ! bone development [Term] id: GO:0048540 name: bursa of Fabricius development namespace: biological_process def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149] is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0048541 name: Peyer's patch development namespace: biological_process def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] synonym: "GALT development" RELATED [] synonym: "gut-associated lymphoid tissue development" RELATED [] is_a: GO:0048537 ! mucosal-associated lymphoid tissue development [Term] id: GO:0048542 name: lymph gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] synonym: "haematopoietic organ development" BROAD [] synonym: "haemopoietic organ development" BROAD [] synonym: "hematopoietic organ development" BROAD [] synonym: "hemopoietic organ development" BROAD [] is_a: GO:0048534 ! hematopoietic or lymphoid organ development is_a: GO:0048732 ! gland development [Term] id: GO:0048543 name: phytochrome chromophore biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515] synonym: "phytochrome chromophore anabolism" EXACT [] synonym: "phytochrome chromophore biosynthesis" EXACT [] synonym: "phytochrome chromophore formation" EXACT [] synonym: "phytochrome chromophore synthesis" EXACT [] is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0048544 name: recognition of pollen namespace: biological_process alt_id: GO:0009857 def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb] synonym: "pollen recognition" EXACT [] synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb] synonym: "self incompatibility" RELATED [] is_a: GO:0008037 ! cell recognition is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0048545 name: response to steroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid [Term] id: GO:0048546 name: digestive tract morphogenesis namespace: biological_process alt_id: GO:0048547 def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] synonym: "alimentary canal morphogenesis" EXACT [] synonym: "digestive tube morphogenesis" EXACT [] synonym: "gastrointestinal tract morphogenesis" EXACT [] synonym: "gut morphogenesis" BROAD [GOC:dph] synonym: "intestinal morphogenesis" NARROW [] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0048548 name: regulation of pinocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] is_a: GO:0030100 ! regulation of endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006907 ! pinocytosis relationship: regulates GO:0006907 ! pinocytosis [Term] id: GO:0048549 name: positive regulation of pinocytosis namespace: biological_process def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] synonym: "activation of pinocytosis" NARROW [] synonym: "stimulation of pinocytosis" NARROW [] synonym: "up regulation of pinocytosis" EXACT [] synonym: "up-regulation of pinocytosis" EXACT [] synonym: "upregulation of pinocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0048548 ! regulation of pinocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006907 ! pinocytosis relationship: positively_regulates GO:0006907 ! pinocytosis [Term] id: GO:0048550 name: negative regulation of pinocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] synonym: "down regulation of pinocytosis" EXACT [] synonym: "down-regulation of pinocytosis" EXACT [] synonym: "downregulation of pinocytosis" EXACT [] synonym: "inhibition of pinocytosis" NARROW [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0048548 ! regulation of pinocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006907 ! pinocytosis relationship: negatively_regulates GO:0006907 ! pinocytosis [Term] id: GO:0048555 name: generative cell nucleus namespace: cellular_component def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators] synonym: "male germ cell nucleus" BROAD [] synonym: "sperm cell nucleus" BROAD [] is_a: GO:0005634 ! nucleus [Term] id: GO:0048556 name: microsporocyte nucleus namespace: cellular_component alt_id: GO:0043074 def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X] synonym: "microspore mother cell nucleus" EXACT [] synonym: "pollen mother cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus [Term] id: GO:0048557 name: embryonic digestive tract morphogenesis namespace: biological_process alt_id: GO:0048558 def: "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "embryonic gut morphogenesis" BROAD [GOC:dph] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0048566 ! embryonic digestive tract development [Term] id: GO:0048559 name: establishment of floral organ orientation namespace: biological_process def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090707 ! establishment of plant organ orientation relationship: part_of GO:0048439 ! flower morphogenesis [Term] id: GO:0048560 name: establishment of anatomical structure orientation namespace: biological_process def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jid] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048561 name: establishment of animal organ orientation namespace: biological_process def: "The process that determines the orientation of an animal organ or tissue with reference to an axis." [GOC:jid] is_a: GO:0048560 ! establishment of anatomical structure orientation relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048568 ! embryonic organ development [Term] id: GO:0048563 name: post-embryonic animal organ morphogenesis namespace: biological_process def: "Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048569 ! post-embryonic animal organ development [Term] id: GO:0048564 name: photosystem I assembly namespace: biological_process alt_id: GO:0010251 def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0048565 name: digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "gut development" BROAD [GOC:dph] synonym: "intestinal development" NARROW [] synonym: "intestine development" NARROW [] xref: MIPS_funcat:47.03.11.05 is_a: GO:0035295 ! tube development relationship: part_of GO:0055123 ! digestive system development [Term] id: GO:0048566 name: embryonic digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] synonym: "embryonic digestive tract development" BROAD [GOC:dph] is_a: GO:0048565 ! digestive tract development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0048567 name: ectodermal digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] synonym: "ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0007439 ! ectodermal digestive tract development relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048569 name: post-embryonic animal organ development namespace: biological_process def: "Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "post-embryonic animal organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis relationship: part_of GO:0030903 ! notochord development [Term] id: GO:0048571 name: long-day photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to long-day" EXACT [] synonym: "response to long-day photoperiod" RELATED [] synonym: "response to short-night" EXACT [] synonym: "short-night photoperiodism" EXACT [] is_a: GO:0009648 ! photoperiodism [Term] id: GO:0048572 name: short-day photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-night photoperiodism" EXACT [] synonym: "response to long-night" EXACT [] synonym: "response to short-day" EXACT [] synonym: "response to short-day photoperiod" RELATED [] is_a: GO:0009648 ! photoperiodism [Term] id: GO:0048573 name: photoperiodism, flowering namespace: biological_process def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "photoperiodic control of flowering time" EXACT [] synonym: "photoperiodic control of inflorescence development" EXACT [] synonym: "response to day length, flowering" EXACT [] synonym: "response to night length, flowering" EXACT [] synonym: "response to photoperiod, flowering" EXACT [] is_a: GO:0009648 ! photoperiodism is_a: GO:0022414 ! reproductive process relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem [Term] id: GO:0048574 name: long-day photoperiodism, flowering namespace: biological_process def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-day photoperiodic control of flowering" EXACT [] synonym: "long-day photoperiodic control of flowering time" EXACT [] synonym: "long-day photoperiodic control of inflorescence development" EXACT [] synonym: "response to long-day, flowering" EXACT [] synonym: "response to short-night, flowering" EXACT [] synonym: "short-night photoperiodism, flowering" EXACT [] is_a: GO:0048571 ! long-day photoperiodism is_a: GO:0048573 ! photoperiodism, flowering [Term] id: GO:0048575 name: short-day photoperiodism, flowering namespace: biological_process def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "long-night photoperiodism, flowering" EXACT [] synonym: "response to long-night, flowering" EXACT [] synonym: "response to short-day, flowering" EXACT [] synonym: "short-day photoperiodic control of flowering" EXACT [] synonym: "short-day photoperiodic control of flowering time" EXACT [] synonym: "short-day photoperiodic control of inflorescence development" EXACT [] is_a: GO:0048572 ! short-day photoperiodism is_a: GO:0048573 ! photoperiodism, flowering [Term] id: GO:0048576 name: positive regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "activation of short-day photoperiodism, flowering" NARROW [] synonym: "stimulation of short-day photoperiodism, flowering" NARROW [] synonym: "up regulation of short-day photoperiodism, flowering" EXACT [] synonym: "up-regulation of short-day photoperiodism, flowering" EXACT [] synonym: "upregulation of short-day photoperiodism, flowering" EXACT [] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048575 ! short-day photoperiodism, flowering relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048577 name: negative regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "down regulation of short-day photoperiodism, flowering" EXACT [] synonym: "down-regulation of short-day photoperiodism, flowering" EXACT [] synonym: "downregulation of short-day photoperiodism, flowering" EXACT [] synonym: "inhibition of short-day photoperiodism, flowering" NARROW [] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048578 name: positive regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "activation of long-day photoperiodism, flowering" NARROW [] synonym: "stimulation of long-day photoperiodism, flowering" NARROW [] synonym: "up regulation of long-day photoperiodism, flowering" EXACT [] synonym: "up-regulation of long-day photoperiodism, flowering" EXACT [] synonym: "upregulation of long-day photoperiodism, flowering" EXACT [] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048574 ! long-day photoperiodism, flowering relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048579 name: negative regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "down regulation of long-day photoperiodism, flowering" EXACT [] synonym: "down-regulation of long-day photoperiodism, flowering" EXACT [] synonym: "downregulation of long-day photoperiodism, flowering" EXACT [] synonym: "inhibition of long-day photoperiodism, flowering" NARROW [] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048580 name: regulation of post-embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009791 ! post-embryonic development relationship: regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048581 name: negative regulation of post-embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "down regulation of post-embryonic development" EXACT [] synonym: "down-regulation of post-embryonic development" EXACT [] synonym: "downregulation of post-embryonic development" EXACT [] synonym: "inhibition of post-embryonic development" NARROW [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009791 ! post-embryonic development relationship: negatively_regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048582 name: positive regulation of post-embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "activation of post-embryonic development" NARROW [] synonym: "stimulation of post-embryonic development" NARROW [] synonym: "up regulation of post-embryonic development" EXACT [] synonym: "up-regulation of post-embryonic development" EXACT [] synonym: "upregulation of post-embryonic development" EXACT [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009791 ! post-embryonic development relationship: positively_regulates GO:0009791 ! post-embryonic development [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050896 ! response to stimulus relationship: regulates GO:0050896 ! response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050896 ! response to stimulus relationship: positively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050896 ! response to stimulus relationship: negatively_regulates GO:0050896 ! response to stimulus [Term] id: GO:0048586 name: regulation of long-day photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] is_a: GO:2000028 ! regulation of photoperiodism, flowering intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048574 ! long-day photoperiodism, flowering relationship: regulates GO:0048574 ! long-day photoperiodism, flowering [Term] id: GO:0048587 name: regulation of short-day photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] is_a: GO:2000028 ! regulation of photoperiodism, flowering intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048575 ! short-day photoperiodism, flowering relationship: regulates GO:0048575 ! short-day photoperiodism, flowering [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048468 ! cell development [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0032502 ! developmental process is_a: GO:0040007 ! growth [Term] id: GO:0048592 name: eye morphogenesis namespace: biological_process alt_id: GO:0048748 def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0001654 ! eye development [Term] id: GO:0048593 name: camera-type eye morphogenesis namespace: biological_process alt_id: GO:0048594 alt_id: GO:0048595 def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0048596 name: embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic eye morphogenesis" BROAD [] is_a: GO:0048048 ! embryonic eye morphogenesis relationship: part_of GO:0031076 ! embryonic camera-type eye development relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0048597 name: post-embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] synonym: "post-embryonic camera-style eye morphogenesis" EXACT [] synonym: "post-embryonic eye morphogenesis" BROAD [] is_a: GO:0048050 ! post-embryonic eye morphogenesis relationship: part_of GO:0031077 ! post-embryonic camera-type eye development relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process alt_id: GO:0048828 def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development relationship: part_of GO:0009994 ! oocyte differentiation [Term] id: GO:0048600 name: oocyte fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0009994 ! oocyte differentiation [Term] id: GO:0048601 name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] xref: MIPS_funcat:45.03.15 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061458 ! reproductive system development [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0048610 name: obsolete cellular process involved in reproduction namespace: biological_process def: "OBSOLETE. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jid] comment: This process was made obsolete because we felt it not provide a particularly useful classification, and its very broad logical definition caused regular problems in our inference pipelines. synonym: "cellular process involved in reproduction" EXACT [] synonym: "reproductive cellular process" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0048611 name: embryonic ectodermal digestive tract development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] synonym: "embryonic ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048566 ! embryonic digestive tract development relationship: part_of GO:0007439 ! ectodermal digestive tract development [Term] id: GO:0048612 name: post-embryonic ectodermal digestive tract development namespace: biological_process def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] synonym: "post-embryonic ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0007439 ! ectodermal digestive tract development [Term] id: GO:0048613 name: embryonic ectodermal digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized." [GOC:jid, GOC:rc] synonym: "embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis relationship: part_of GO:0048611 ! embryonic ectodermal digestive tract development [Term] id: GO:0048614 name: post-embryonic ectodermal digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized." [GOC:jid, GOC:rc] synonym: "post-embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis relationship: part_of GO:0048612 ! post-embryonic ectodermal digestive tract development relationship: part_of GO:0048621 ! post-embryonic digestive tract morphogenesis [Term] id: GO:0048615 name: embryonic anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis relationship: part_of GO:0048613 ! embryonic ectodermal digestive tract morphogenesis [Term] id: GO:0048616 name: post-embryonic anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis relationship: part_of GO:0048614 ! post-embryonic ectodermal digestive tract morphogenesis [Term] id: GO:0048617 name: embryonic foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007440 ! foregut morphogenesis [Term] id: GO:0048618 name: post-embryonic foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007440 ! foregut morphogenesis [Term] id: GO:0048619 name: embryonic hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007442 ! hindgut morphogenesis [Term] id: GO:0048620 name: post-embryonic hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007442 ! hindgut morphogenesis [Term] id: GO:0048621 name: post-embryonic digestive tract morphogenesis namespace: biological_process def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:jid, GOC:rc] synonym: "post-embryonic gut morphogenesis" BROAD [GOC:dph] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0048622 name: obsolete reproductive sporulation namespace: biological_process def: "OBSOLETE. The formation of reproductive spores." [GOC:jid] comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology. synonym: "reproductive sporulation" EXACT [] is_obsolete: true [Term] id: GO:0048623 name: seed germination on parent plant namespace: biological_process def: "The process in which a seed germinates before being shed from the parent plant." [GOC:go_curators] synonym: "non-vegetative vivipary" BROAD [] synonym: "pre-harvest sprouting" EXACT [] synonym: "vivipary" BROAD [] is_a: GO:0009845 ! seed germination [Term] id: GO:0048624 name: plantlet formation on parent plant namespace: biological_process def: "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators] synonym: "vegetative vivipary" BROAD [] synonym: "vivipary" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0019954 ! asexual reproduction is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048507 ! meristem development is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0048625 name: myoblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0045445 ! myoblast differentiation [Term] id: GO:0048626 name: myoblast fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048625 ! myoblast fate commitment [Term] id: GO:0048627 name: myoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048468 ! cell development relationship: part_of GO:0045445 ! myoblast differentiation [Term] id: GO:0048628 name: myoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048627 ! myoblast development [Term] id: GO:0048629 name: trichome patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181] synonym: "trichome distribution" BROAD [] synonym: "trichome pattern biosynthesis" EXACT [] synonym: "trichome pattern formation" EXACT [] synonym: "trichome pattern specification" RELATED [] synonym: "trichome spacing" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0010026 ! trichome differentiation [Term] id: GO:0048630 name: skeletal muscle tissue growth namespace: biological_process def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048631 name: regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048630 ! skeletal muscle tissue growth relationship: regulates GO:0048630 ! skeletal muscle tissue growth [Term] id: GO:0048632 name: negative regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "down regulation of skeletal muscle growth" EXACT [] synonym: "down-regulation of skeletal muscle growth" EXACT [] synonym: "downregulation of skeletal muscle growth" EXACT [] synonym: "inhibition of skeletal muscle growth" NARROW [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048630 ! skeletal muscle tissue growth relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth [Term] id: GO:0048633 name: positive regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "activation of skeletal muscle growth" NARROW [] synonym: "stimulation of skeletal muscle growth" NARROW [] synonym: "up regulation of skeletal muscle growth" EXACT [] synonym: "up-regulation of skeletal muscle growth" EXACT [] synonym: "upregulation of skeletal muscle growth" EXACT [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048630 ! skeletal muscle tissue growth relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth [Term] id: GO:0048634 name: regulation of muscle organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007517 ! muscle organ development relationship: regulates GO:0007517 ! muscle organ development [Term] id: GO:0048635 name: negative regulation of muscle organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] synonym: "down regulation of muscle development" EXACT [] synonym: "down-regulation of muscle development" EXACT [] synonym: "downregulation of muscle development" EXACT [] synonym: "inhibition of muscle development" NARROW [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007517 ! muscle organ development relationship: negatively_regulates GO:0007517 ! muscle organ development [Term] id: GO:0048636 name: positive regulation of muscle organ development namespace: biological_process def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] synonym: "activation of muscle development" NARROW [] synonym: "stimulation of muscle development" NARROW [] synonym: "up regulation of muscle development" EXACT [] synonym: "up-regulation of muscle development" EXACT [] synonym: "upregulation of muscle development" EXACT [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007517 ! muscle organ development relationship: positively_regulates GO:0007517 ! muscle organ development [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048589 ! developmental growth relationship: regulates GO:0048589 ! developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048589 ! developmental growth relationship: positively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048589 ! developmental growth relationship: negatively_regulates GO:0048589 ! developmental growth [Term] id: GO:0048641 name: regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007519 ! skeletal muscle tissue development relationship: regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048642 name: negative regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] synonym: "down regulation of skeletal muscle development" EXACT [] synonym: "down-regulation of skeletal muscle development" EXACT [] synonym: "downregulation of skeletal muscle development" EXACT [] synonym: "inhibition of skeletal muscle development" NARROW [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007519 ! skeletal muscle tissue development relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048643 name: positive regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] synonym: "activation of skeletal muscle development" NARROW [] synonym: "stimulation of skeletal muscle development" NARROW [] synonym: "up regulation of skeletal muscle development" EXACT [] synonym: "up-regulation of skeletal muscle development" EXACT [] synonym: "upregulation of skeletal muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007519 ! skeletal muscle tissue development relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048644 name: muscle organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007517 ! muscle organ development [Term] id: GO:0048645 name: animal organ formation namespace: biological_process def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] synonym: "animal organ primordium initiation" NARROW [] synonym: "initiation of an animal organ primordium" NARROW [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0048647 name: polyphenic determination namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jid] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0048648 name: caste determination namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048649 name: caste determination, influence by genetic factors namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048648 ! caste determination is_a: GO:0048652 ! polyphenic determination, influence by genetic factors [Term] id: GO:0048650 name: caste determination, influence by environmental factors namespace: biological_process def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] is_a: GO:0048648 ! caste determination is_a: GO:0048651 ! polyphenic determination, influence by environmental factors [Term] id: GO:0048651 name: polyphenic determination, influence by environmental factors namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jid] is_a: GO:0009605 ! response to external stimulus is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048652 name: polyphenic determination, influence by genetic factors namespace: biological_process def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jid] is_a: GO:0048647 ! polyphenic determination [Term] id: GO:0048653 name: anther development namespace: biological_process def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jid, GOC:sm] xref: MIPS_funcat:47.02.01.03.03 is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048443 ! stamen development [Term] id: GO:0048654 name: anther morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anther are generated and organized." [GOC:jid, GOC:sm] is_a: GO:0048444 ! floral organ morphogenesis relationship: part_of GO:0048448 ! stamen morphogenesis relationship: part_of GO:0048653 ! anther development [Term] id: GO:0048655 name: anther wall tapetum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb] synonym: "differentiation of tapetal layer" NARROW [] synonym: "tapetal layer morphogenesis" BROAD [GOC:tb] synonym: "tapetum morphogenesis" BROAD [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0048654 ! anther morphogenesis relationship: part_of GO:0048658 ! anther wall tapetum development [Term] id: GO:0048656 name: anther wall tapetum formation namespace: biological_process def: "The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb] synonym: "tapetal layer formation" BROAD [GOC:tb] synonym: "tapetum formation" BROAD [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048455 ! stamen formation relationship: part_of GO:0048655 ! anther wall tapetum morphogenesis [Term] id: GO:0048657 name: anther wall tapetum cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm] synonym: "tapetal cell differentiation" BROAD [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048656 ! anther wall tapetum formation [Term] id: GO:0048658 name: anther wall tapetum development namespace: biological_process def: "The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure." [GOC:jid, GOC:sm, GOC:tb] synonym: "tapetal layer development" BROAD [GOC:tb] synonym: "tapetum development" BROAD [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048653 ! anther development [Term] id: GO:0048659 name: smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] synonym: "SMC proliferation" EXACT [] is_a: GO:0033002 ! muscle cell proliferation [Term] id: GO:0048660 name: regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "regulation of SMC proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048659 ! smooth muscle cell proliferation relationship: regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048661 name: positive regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "activation of smooth muscle cell proliferation" NARROW [] synonym: "positive regulation of SMC proliferation" EXACT [] synonym: "stimulation of smooth muscle cell proliferation" NARROW [] synonym: "up regulation of smooth muscle cell proliferation" EXACT [] synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] synonym: "upregulation of smooth muscle cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048659 ! smooth muscle cell proliferation relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048662 name: negative regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "down regulation of smooth muscle cell proliferation" EXACT [] synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] synonym: "downregulation of smooth muscle cell proliferation" EXACT [] synonym: "inhibition of smooth muscle cell proliferation" NARROW [] synonym: "negative regulation of SMC proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048659 ! smooth muscle cell proliferation relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation [Term] id: GO:0048663 name: neuron fate commitment namespace: biological_process alt_id: GO:0042055 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] synonym: "neuron lineage restriction" EXACT [] synonym: "neuronal lineage restriction" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048664 name: neuron fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048663 ! neuron fate commitment [Term] id: GO:0048665 name: neuron fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048663 ! neuron fate commitment [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030182 ! neuron differentiation [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0048668 name: collateral sprouting namespace: biological_process def: "The process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "axon branching" BROAD [GOC:BHF, PMID:21463686] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0048669 name: collateral sprouting in absence of injury namespace: biological_process def: "The process in which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048668 ! collateral sprouting [Term] id: GO:0048670 name: regulation of collateral sprouting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048668 ! collateral sprouting relationship: regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048671 name: negative regulation of collateral sprouting namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting" EXACT [] synonym: "down-regulation of collateral sprouting" EXACT [] synonym: "downregulation of collateral sprouting" EXACT [] synonym: "inhibition of collateral sprouting" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0050771 ! negative regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048668 ! collateral sprouting relationship: negatively_regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048672 name: positive regulation of collateral sprouting namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting" NARROW [] synonym: "stimulation of collateral sprouting" NARROW [] synonym: "up regulation of collateral sprouting" EXACT [] synonym: "up-regulation of collateral sprouting" EXACT [] synonym: "upregulation of collateral sprouting" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0050772 ! positive regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048668 ! collateral sprouting relationship: positively_regulates GO:0048668 ! collateral sprouting [Term] id: GO:0048673 name: collateral sprouting of intact axon in response to injury namespace: biological_process def: "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0031103 ! axon regeneration is_a: GO:0048668 ! collateral sprouting [Term] id: GO:0048674 name: collateral sprouting of injured axon namespace: biological_process def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048668 ! collateral sprouting is_a: GO:0048682 ! sprouting of injured axon [Term] id: GO:0048675 name: axon extension namespace: biological_process alt_id: GO:0048676 def: "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] synonym: "axon extension involved in development" EXACT [] is_a: GO:1990138 ! neuron projection extension relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0048677 name: axon extension involved in regeneration namespace: biological_process def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid] is_a: GO:0048675 ! axon extension is_a: GO:0048682 ! sprouting of injured axon intersection_of: GO:0048675 ! axon extension intersection_of: part_of GO:0031099 ! regeneration [Term] id: GO:0048678 name: response to axon injury namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0009611 ! response to wounding [Term] id: GO:0048679 name: regulation of axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0070570 ! regulation of neuron projection regeneration is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031103 ! axon regeneration relationship: regulates GO:0031103 ! axon regeneration [Term] id: GO:0048680 name: positive regulation of axon regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon regeneration" NARROW [] synonym: "stimulation of axon regeneration" NARROW [] synonym: "up regulation of axon regeneration" EXACT [] synonym: "up-regulation of axon regeneration" EXACT [] synonym: "upregulation of axon regeneration" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0070572 ! positive regulation of neuron projection regeneration is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031103 ! axon regeneration relationship: positively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048681 name: negative regulation of axon regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon regeneration" EXACT [] synonym: "down-regulation of axon regeneration" EXACT [] synonym: "downregulation of axon regeneration" EXACT [] synonym: "inhibition of axon regeneration" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0070571 ! negative regulation of neuron projection regeneration is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031103 ! axon regeneration relationship: negatively_regulates GO:0031103 ! axon regeneration [Term] id: GO:0048682 name: sprouting of injured axon namespace: biological_process def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0031103 ! axon regeneration [Term] id: GO:0048683 name: regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0048679 ! regulation of axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048684 name: positive regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW [] synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW [] synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048685 name: negative regulation of collateral sprouting of intact axon in response to injury namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT [] synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury [Term] id: GO:0048686 name: regulation of sprouting of injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048679 ! regulation of axon regeneration is_a: GO:0061387 ! regulation of extent of cell growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048682 ! sprouting of injured axon relationship: regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048687 name: positive regulation of sprouting of injured axon namespace: biological_process def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of sprouting of injured axon" NARROW [] synonym: "stimulation of sprouting of injured axon" NARROW [] synonym: "up regulation of sprouting of injured axon" EXACT [] synonym: "up-regulation of sprouting of injured axon" EXACT [] synonym: "upregulation of sprouting of injured axon" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048682 ! sprouting of injured axon relationship: positively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048688 name: negative regulation of sprouting of injured axon namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of sprouting of injured axon" EXACT [] synonym: "down-regulation of sprouting of injured axon" EXACT [] synonym: "downregulation of sprouting of injured axon" EXACT [] synonym: "inhibition of sprouting of injured axon" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048682 ! sprouting of injured axon relationship: negatively_regulates GO:0048682 ! sprouting of injured axon [Term] id: GO:0048689 name: formation of growth cone in injured axon namespace: biological_process def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048682 ! sprouting of injured axon [Term] id: GO:0048690 name: regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048677 ! axon extension involved in regeneration relationship: regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048691 name: positive regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of axon extension involved in regeneration" NARROW [] synonym: "stimulation of axon extension involved in regeneration" NARROW [] synonym: "up regulation of axon extension involved in regeneration" EXACT [] synonym: "up-regulation of axon extension involved in regeneration" EXACT [] synonym: "upregulation of axon extension involved in regeneration" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048677 ! axon extension involved in regeneration relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048692 name: negative regulation of axon extension involved in regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of axon extension involved in regeneration" EXACT [] synonym: "down-regulation of axon extension involved in regeneration" EXACT [] synonym: "downregulation of axon extension involved in regeneration" EXACT [] synonym: "inhibition of axon extension involved in regeneration" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:0048690 ! regulation of axon extension involved in regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048677 ! axon extension involved in regeneration relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration [Term] id: GO:0048693 name: regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048674 ! collateral sprouting of injured axon relationship: regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048694 name: positive regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting of injured axon" NARROW [] synonym: "stimulation of collateral sprouting of injured axon" NARROW [] synonym: "up regulation of collateral sprouting of injured axon" EXACT [] synonym: "up-regulation of collateral sprouting of injured axon" EXACT [] synonym: "upregulation of collateral sprouting of injured axon" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:0048693 ! regulation of collateral sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048674 ! collateral sprouting of injured axon relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048695 name: negative regulation of collateral sprouting of injured axon namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting of injured axon" EXACT [] synonym: "down-regulation of collateral sprouting of injured axon" EXACT [] synonym: "downregulation of collateral sprouting of injured axon" EXACT [] synonym: "inhibition of collateral sprouting of injured axon" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:0048693 ! regulation of collateral sprouting of injured axon intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048674 ! collateral sprouting of injured axon relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon [Term] id: GO:0048696 name: regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] is_a: GO:0048670 ! regulation of collateral sprouting intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048669 ! collateral sprouting in absence of injury relationship: regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048697 name: positive regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "activation of collateral sprouting in the absence of injury" NARROW [] synonym: "stimulation of collateral sprouting in the absence of injury" NARROW [] synonym: "up regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "upregulation of collateral sprouting in the absence of injury" EXACT [] is_a: GO:0048672 ! positive regulation of collateral sprouting is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048669 ! collateral sprouting in absence of injury relationship: positively_regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048698 name: negative regulation of collateral sprouting in absence of injury namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] synonym: "down regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT [] synonym: "downregulation of collateral sprouting in the absence of injury" EXACT [] synonym: "inhibition of collateral sprouting in the absence of injury" NARROW [] is_a: GO:0048671 ! negative regulation of collateral sprouting is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury relationship: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] xref: MIPS_funcat:41.05.13 is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048700 name: acquisition of desiccation tolerance in seed namespace: biological_process def: "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jid, GOC:ki, GOC:PO_curators, ISBN:9781405139830] synonym: "acquisition of desiccation tolerance" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0097439 ! acquisition of desiccation tolerance relationship: part_of GO:0010162 ! seed dormancy process [Term] id: GO:0048701 name: embryonic cranial skeleton morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic cranium morphogenesis" EXACT [] is_a: GO:0048704 ! embryonic skeletal system morphogenesis relationship: part_of GO:1904888 ! cranial skeletal system development [Term] id: GO:0048702 name: embryonic neurocranium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic braincase morphogenesis" EXACT [] synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis [Term] id: GO:0048703 name: embryonic viscerocranium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jid, PMID:16049113] synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis [Term] id: GO:0048704 name: embryonic skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0048706 ! embryonic skeletal system development [Term] id: GO:0048705 name: skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0001501 ! skeletal system development [Term] id: GO:0048706 name: embryonic skeletal system development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb] is_a: GO:0001501 ! skeletal system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0048707 name: instar larval or pupal morphogenesis namespace: biological_process def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002165 ! instar larval or pupal development [Term] id: GO:0048708 name: astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0048709 name: oligodendrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0048710 name: regulation of astrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048708 ! astrocyte differentiation relationship: regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048711 name: positive regulation of astrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of astrocyte differentiation" NARROW [] synonym: "stimulation of astrocyte differentiation" NARROW [] synonym: "up regulation of astrocyte differentiation" EXACT [] synonym: "up-regulation of astrocyte differentiation" EXACT [] synonym: "upregulation of astrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048708 ! astrocyte differentiation relationship: positively_regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048712 name: negative regulation of astrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of astrocyte differentiation" EXACT [] synonym: "down-regulation of astrocyte differentiation" EXACT [] synonym: "downregulation of astrocyte differentiation" EXACT [] synonym: "inhibition of astrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048708 ! astrocyte differentiation relationship: negatively_regulates GO:0048708 ! astrocyte differentiation [Term] id: GO:0048713 name: regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048709 ! oligodendrocyte differentiation relationship: regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048714 name: positive regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of oligodendrocyte differentiation" NARROW [] synonym: "stimulation of oligodendrocyte differentiation" NARROW [] synonym: "up regulation of oligodendrocyte differentiation" EXACT [] synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] synonym: "upregulation of oligodendrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048709 ! oligodendrocyte differentiation relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048715 name: negative regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of oligodendrocyte differentiation" EXACT [] synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] synonym: "downregulation of oligodendrocyte differentiation" EXACT [] synonym: "inhibition of oligodendrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048709 ! oligodendrocyte differentiation relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0048716 name: labrum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of labrum are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048726 ! labrum development [Term] id: GO:0048717 name: anterior cibarial plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048722 ! anterior cibarial plate development [Term] id: GO:0048718 name: cibarial fish-trap bristle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc] synonym: "fish trap bristle morphogenesis" RELATED [GOC:rc] is_a: GO:0008407 ! chaeta morphogenesis is_a: GO:0048563 ! post-embryonic animal organ morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048725 ! cibarial fish-trap bristle development [Term] id: GO:0048719 name: epistomal sclerite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048724 ! epistomal sclerite development [Term] id: GO:0048720 name: posterior cibarial plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048727 ! posterior cibarial plate development [Term] id: GO:0048721 name: clypeus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048723 ! clypeus development [Term] id: GO:0048722 name: anterior cibarial plate development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048723 name: clypeus development namespace: biological_process def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048724 name: epistomal sclerite development namespace: biological_process def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048725 name: cibarial fish-trap bristle development namespace: biological_process def: "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc] synonym: "fish-trap bristle development" EXACT [GOC:rc] is_a: GO:0022416 ! chaeta development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048726 name: labrum development namespace: biological_process def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048727 name: posterior cibarial plate development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048728 name: proboscis development namespace: biological_process alt_id: GO:0016349 def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009888 ! tissue development [Term] id: GO:0048730 name: epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0008544 ! epidermis development [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0048732 name: gland development namespace: biological_process def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] xref: MIPS_funcat:45.03.19 xref: MIPS_funcat:47.03.21 is_a: GO:0048513 ! animal organ development [Term] id: GO:0048733 name: sebaceous gland development namespace: biological_process def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048732 ! gland development relationship: part_of GO:0043588 ! skin development [Term] id: GO:0048734 name: proboscis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048728 ! proboscis development [Term] id: GO:0048735 name: haltere morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007481 ! haltere disc morphogenesis relationship: part_of GO:0007482 ! haltere development [Term] id: GO:0048736 name: appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] xref: MIPS_funcat:41.05.21 is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0048737 name: imaginal disc-derived appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc] is_a: GO:0048736 ! appendage development [Term] id: GO:0048738 name: cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "heart muscle development" EXACT [] xref: MIPS_funcat:45.03.12.03 is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0048739 name: cardiac muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "cardiac muscle fibre development" EXACT [] synonym: "heart muscle fiber development" RELATED [] is_a: GO:0048747 ! muscle fiber development is_a: GO:0055013 ! cardiac muscle cell development [Term] id: GO:0048740 name: obsolete striated muscle fiber development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms. synonym: "myogenesis" EXACT [] synonym: "striated muscle fiber development" EXACT [] synonym: "striated muscle fibre development" EXACT [] is_obsolete: true [Term] id: GO:0048741 name: skeletal muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "skeletal muscle fibre development" EXACT [] synonym: "skeletal myofiber development" EXACT [] synonym: "skeletal myofibre development" EXACT [] is_a: GO:0014904 ! myotube cell development is_a: GO:0048747 ! muscle fiber development relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0048742 name: regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] synonym: "regulation of skeletal muscle fibre development" EXACT [] synonym: "regulation of skeletal myofiber development" EXACT [] synonym: "regulation of skeletal myofibre development" EXACT [] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0048641 ! regulation of skeletal muscle tissue development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048741 ! skeletal muscle fiber development relationship: regulates GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0048743 name: positive regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "activation of skeletal muscle fiber development" NARROW [] synonym: "positive regulation of skeletal muscle fibre development" EXACT [] synonym: "positive regulation of skeletal myofiber development" EXACT [] synonym: "positive regulation of skeletal myofibre development" EXACT [] synonym: "stimulation of skeletal muscle fiber development" NARROW [] synonym: "up regulation of skeletal muscle fiber development" EXACT [] synonym: "up-regulation of skeletal muscle fiber development" EXACT [] synonym: "upregulation of skeletal muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048741 ! skeletal muscle fiber development relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0048744 name: negative regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "down regulation of skeletal muscle fiber development" EXACT [] synonym: "down-regulation of skeletal muscle fiber development" EXACT [] synonym: "downregulation of skeletal muscle fiber development" EXACT [] synonym: "inhibition of skeletal muscle fiber development" NARROW [] synonym: "negative regulation of skeletal muscle fibre development" EXACT [] synonym: "negative regulation of skeletal myofiber development" EXACT [] synonym: "negative regulation of skeletal myofibre development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048741 ! skeletal muscle fiber development relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0048745 name: smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] xref: MIPS_funcat:45.03.12.02 is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0048746 name: obsolete smooth muscle fiber development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] comment: This term was made obsolete because smooth muscle does not have fibers. synonym: "smooth muscle fiber development" EXACT [] synonym: "smooth muscle fibre development" EXACT [] is_obsolete: true [Term] id: GO:0048747 name: muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "muscle fibre development" EXACT [] synonym: "myofiber development" EXACT [] synonym: "myofibre development" EXACT [] is_a: GO:0055002 ! striated muscle cell development [Term] id: GO:0048749 name: compound eye development namespace: biological_process alt_id: GO:0007456 def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] synonym: "insect-type retina development" EXACT [PMID:11735386] is_a: GO:0001654 ! eye development [Term] id: GO:0048750 name: compound eye corneal lens morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001745 ! compound eye morphogenesis relationship: part_of GO:0048058 ! compound eye corneal lens development [Term] id: GO:0048752 name: semicircular canal morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid] synonym: "embryonic semicircular canal morphogenesis" EXACT [] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060872 ! semicircular canal development [Term] id: GO:0048753 name: pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] subset: goslim_pir synonym: "pigment granule organisation" EXACT [] synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0033059 ! cellular pigmentation [Term] id: GO:0048754 name: branching morphogenesis of an epithelial tube namespace: biological_process def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060562 ! epithelial tube morphogenesis [Term] id: GO:0048755 name: branching morphogenesis of a nerve namespace: biological_process def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001763 ! morphogenesis of a branching structure relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0048756 name: sieve cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [GOC:jid, PO:0025415, POC:curators] is_a: GO:0090603 ! sieve element differentiation relationship: part_of GO:0010088 ! phloem development [Term] id: GO:0048757 name: pigment granule maturation namespace: biological_process def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh] is_a: GO:0021700 ! developmental maturation is_a: GO:0043482 ! cellular pigment accumulation relationship: part_of GO:0050931 ! pigment cell differentiation [Term] id: GO:0048758 name: companion cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid] is_a: GO:0048760 ! plant parenchymal cell differentiation relationship: part_of GO:0010088 ! phloem development [Term] id: GO:0048759 name: xylem vessel member cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003] synonym: "vessel element cell differentiation" BROAD [] synonym: "vessel member cell differentiation" BROAD [] is_a: GO:1905177 ! tracheary element differentiation relationship: part_of GO:0010089 ! xylem development [Term] id: GO:0048760 name: plant parenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421] synonym: "parenchymal cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048761 name: collenchyma cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048762 name: mesenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060485 ! mesenchyme development [Term] id: GO:0048763 name: calcium-induced calcium release activity namespace: molecular_function def: "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752] is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0048764 name: trichoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0048765 name: root hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid] is_a: GO:0010053 ! root epidermal cell differentiation is_a: GO:0048764 ! trichoblast maturation [Term] id: GO:0048766 name: root hair initiation namespace: biological_process def: "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0048765 ! root hair cell differentiation [Term] id: GO:0048767 name: root hair elongation namespace: biological_process def: "The process in which the root hair grows longer." [GOC:jid, PMID:12468740] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0080147 ! root hair cell development [Term] id: GO:0048768 name: root hair cell tip growth namespace: biological_process def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740] synonym: "root hair tip growth" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0009932 ! cell tip growth relationship: part_of GO:0048767 ! root hair elongation [Term] id: GO:0048769 name: sarcomerogenesis namespace: biological_process def: "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030] synonym: "myofibril production" EXACT systematic_synonym [] is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0030239 ! myofibril assembly [Term] id: GO:0048770 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0048771 name: tissue remodeling namespace: biological_process def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0048772 name: leucophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh] synonym: "leucophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048773 name: erythrophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh] synonym: "erythrophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048774 name: cyanophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh] synonym: "cyanophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0048775 name: regulation of leucophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048772 ! leucophore differentiation relationship: regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048776 name: negative regulation of leucophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "down regulation of leucophore differentiation" EXACT [] synonym: "down-regulation of leucophore differentiation" EXACT [] synonym: "downregulation of leucophore differentiation" EXACT [] synonym: "inhibition of leucophore differentiation" NARROW [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048772 ! leucophore differentiation relationship: negatively_regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048777 name: positive regulation of leucophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh] synonym: "activation of leucophore differentiation" NARROW [] synonym: "stimulation of leucophore differentiation" NARROW [] synonym: "up regulation of leucophore differentiation" EXACT [] synonym: "up-regulation of leucophore differentiation" EXACT [] synonym: "upregulation of leucophore differentiation" EXACT [] is_a: GO:0048775 ! regulation of leucophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048772 ! leucophore differentiation relationship: positively_regulates GO:0048772 ! leucophore differentiation [Term] id: GO:0048778 name: regulation of erythrophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048773 ! erythrophore differentiation relationship: regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048779 name: negative regulation of erythrophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "down regulation of erythrophore differentiation" EXACT [] synonym: "down-regulation of erythrophore differentiation" EXACT [] synonym: "downregulation of erythrophore differentiation" EXACT [] synonym: "inhibition of erythrophore differentiation" NARROW [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048773 ! erythrophore differentiation relationship: negatively_regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048780 name: positive regulation of erythrophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh] synonym: "activation of erythrophore differentiation" NARROW [] synonym: "stimulation of erythrophore differentiation" NARROW [] synonym: "up regulation of erythrophore differentiation" EXACT [] synonym: "up-regulation of erythrophore differentiation" EXACT [] synonym: "upregulation of erythrophore differentiation" EXACT [] is_a: GO:0048778 ! regulation of erythrophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048773 ! erythrophore differentiation relationship: positively_regulates GO:0048773 ! erythrophore differentiation [Term] id: GO:0048781 name: regulation of cyanophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048774 ! cyanophore differentiation relationship: regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048782 name: negative regulation of cyanophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "down regulation of cyanophore differentiation" EXACT [] synonym: "down-regulation of cyanophore differentiation" EXACT [] synonym: "downregulation of cyanophore differentiation" EXACT [] synonym: "inhibition of cyanophore differentiation" NARROW [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048774 ! cyanophore differentiation relationship: negatively_regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048783 name: positive regulation of cyanophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh] synonym: "activation of cyanophore differentiation" NARROW [] synonym: "stimulation of cyanophore differentiation" NARROW [] synonym: "up regulation of cyanophore differentiation" EXACT [] synonym: "up-regulation of cyanophore differentiation" EXACT [] synonym: "upregulation of cyanophore differentiation" EXACT [] is_a: GO:0048781 ! regulation of cyanophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048774 ! cyanophore differentiation relationship: positively_regulates GO:0048774 ! cyanophore differentiation [Term] id: GO:0048784 name: pigment biosynthetic process involved in pigment granule maturation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid] synonym: "pigment biosynthetic process during pigment granule maturation" RELATED [GOC:dph, GOC:tb] is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation intersection_of: GO:0046148 ! pigment biosynthetic process intersection_of: part_of GO:0048757 ! pigment granule maturation relationship: part_of GO:0048757 ! pigment granule maturation [Term] id: GO:0048785 name: hatching gland development namespace: biological_process def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid] is_a: GO:0048732 ! gland development [Term] id: GO:0048786 name: presynaptic active zone namespace: cellular_component def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] subset: goslim_synapse synonym: "pre-synaptic active zone" EXACT [] synonym: "pre-synaptic active zone component" NARROW [NIF_Subcellular:sao1911631652] synonym: "presynaptic specialization" EXACT [] xref: NIF_Subcellular:sao792027222 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0048787 name: presynaptic active zone membrane namespace: cellular_component def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289] subset: goslim_synapse synonym: "active zone plasma membrane" EXACT [NIF_Subcellular:sao2038461087] synonym: "active zone pre-synaptic plasma membrane" EXACT [] synonym: "active zone presynaptic plasma membrane" EXACT [] synonym: "pre-synaptic active zone membrane" EXACT [] xref: NIF_Subcellular:sao2038461087 is_a: GO:0097060 ! synaptic membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0042734 ! presynaptic membrane intersection_of: part_of GO:0048786 ! presynaptic active zone relationship: part_of GO:0042734 ! presynaptic membrane relationship: part_of GO:0048786 ! presynaptic active zone [Term] id: GO:0048788 name: cytoskeleton of presynaptic active zone namespace: cellular_component def: "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438] synonym: "active zone cytomatrix" EXACT [] synonym: "CAZ" NARROW [] synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" EXACT [] synonym: "pre-synaptic dense body" NARROW [NIF_Subcellular:sao1111202255, PMID:12575947] synonym: "pre-synaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179] synonym: "presynaptic cytomatrix assembled at active zones" EXACT [] synonym: "presynaptic cytoskeletal matrix" EXACT syngo_official_label [] synonym: "presynaptic cytoskeletal matrix assembled at active zones" EXACT [] synonym: "presynaptic dense body" NARROW [PMID:16709774] synonym: "presynaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179] synonym: "ribbon" RELATED [NIF_Subcellular:sao1111202255, PMID:12575947] synonym: "synaptic ribbon" NARROW [PMID:19264728] synonym: "T-bar" NARROW [PMID:20127822] synonym: "T-bar ribbon" NARROW [PMID:16384719] xref: NIF_Subcellular:sao1470121605 is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0030863 ! cortical cytoskeleton intersection_of: part_of GO:0098831 ! presynaptic active zone cytoplasmic component relationship: part_of GO:0098831 ! presynaptic active zone cytoplasmic component [Term] id: GO:0048789 name: cytoskeletal matrix organization at active zone namespace: biological_process def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759] synonym: "cytoskeletal matrix organisation at active zone" EXACT [GOC:mah] is_a: GO:0030865 ! cortical cytoskeleton organization [Term] id: GO:0048790 name: maintenance of presynaptic active zone structure namespace: biological_process def: "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] subset: goslim_synapse synonym: "maintenance of pre-synaptic active zone structure" EXACT [] is_a: GO:0099558 ! maintenance of synapse structure is_a: GO:1990709 ! presynaptic active zone organization [Term] id: GO:0048791 name: calcium ion-regulated exocytosis of neurotransmitter namespace: biological_process def: "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators] is_a: GO:0016079 ! synaptic vesicle exocytosis is_a: GO:0017156 ! calcium-ion regulated exocytosis [Term] id: GO:0048792 name: spontaneous exocytosis of neurotransmitter namespace: biological_process def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] synonym: "spontaneous synaptic vesicle exocytosis" EXACT [] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0048793 name: pronephros development namespace: biological_process def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151] synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0001822 ! kidney development [Term] id: GO:0048794 name: swim bladder development namespace: biological_process def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder development" EXACT [] is_a: GO:0048513 ! animal organ development [Term] id: GO:0048795 name: swim bladder morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder morphogenesis" EXACT [] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048794 ! swim bladder development [Term] id: GO:0048796 name: swim bladder maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol] synonym: "gas bladder maturation" EXACT [] is_a: GO:0048799 ! animal organ maturation relationship: part_of GO:0048794 ! swim bladder development [Term] id: GO:0048797 name: swim bladder formation namespace: biological_process def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder biosynthesis" EXACT [] synonym: "gas bladder formation" EXACT [] is_a: GO:0048645 ! animal organ formation relationship: part_of GO:0048795 ! swim bladder morphogenesis [Term] id: GO:0048798 name: swim bladder inflation namespace: biological_process def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] synonym: "gas bladder inflation" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048796 ! swim bladder maturation [Term] id: GO:0048799 name: animal organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0048800 name: antennal morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0035107 ! appendage morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0007469 ! antennal development [Term] id: GO:0048801 name: antennal joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0048098 ! antennal joint development relationship: part_of GO:0048800 ! antennal morphogenesis [Term] id: GO:0048802 name: notum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis relationship: part_of GO:0007477 ! notum development [Term] id: GO:0048803 name: imaginal disc-derived male genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] synonym: "male genital morphogenesis" BROAD [] is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis is_a: GO:0048808 ! male genitalia morphogenesis relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development [Term] id: GO:0048804 name: imaginal disc-derived female genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu] synonym: "female genital morphogenesis" BROAD [] is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis is_a: GO:0048807 ! female genitalia morphogenesis relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development [Term] id: GO:0048805 name: imaginal disc-derived genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] synonym: "genital morphogenesis" BROAD [] is_a: GO:0035126 ! post-embryonic genitalia morphogenesis relationship: part_of GO:0007483 ! genital disc morphogenesis relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0048806 name: genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] synonym: "genital development" EXACT [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0007548 ! sex differentiation [Term] id: GO:0048807 name: female genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah] synonym: "female genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis relationship: part_of GO:0030540 ! female genitalia development [Term] id: GO:0048808 name: male genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888] synonym: "male genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0090598 ! male anatomical structure morphogenesis relationship: part_of GO:0030539 ! male genitalia development [Term] id: GO:0048809 name: analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007483 ! genital disc morphogenesis relationship: part_of GO:0007487 ! analia development [Term] id: GO:0048810 name: female analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0048809 ! analia morphogenesis relationship: part_of GO:0045497 ! female analia development [Term] id: GO:0048811 name: male analia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318] is_a: GO:0048809 ! analia morphogenesis relationship: part_of GO:0045496 ! male analia development [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis relationship: part_of GO:0031175 ! neuron projection development [Term] id: GO:0048813 name: dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0016358 ! dendrite development relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation [Term] id: GO:0048814 name: regulation of dendrite morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048813 ! dendrite morphogenesis relationship: regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0048815 name: hermaphrodite genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0035262 ! gonad morphogenesis relationship: part_of GO:0040035 ! hermaphrodite genitalia development [Term] id: GO:0048816 name: ocellus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0008056 ! ocellus development [Term] id: GO:0048817 name: negative regulation of hair follicle maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "down regulation of hair follicle maturation" EXACT [] synonym: "down-regulation of hair follicle maturation" EXACT [] synonym: "downregulation of hair follicle maturation" EXACT [] synonym: "inhibition of hair follicle maturation" NARROW [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051799 ! negative regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048820 ! hair follicle maturation relationship: negatively_regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048818 name: positive regulation of hair follicle maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] synonym: "activation of hair follicle maturation" NARROW [] synonym: "stimulation of hair follicle maturation" NARROW [] synonym: "up regulation of hair follicle maturation" EXACT [] synonym: "up-regulation of hair follicle maturation" EXACT [] synonym: "upregulation of hair follicle maturation" EXACT [] is_a: GO:0048819 ! regulation of hair follicle maturation is_a: GO:0051798 ! positive regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048820 ! hair follicle maturation relationship: positively_regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048819 name: regulation of hair follicle maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048820 ! hair follicle maturation relationship: regulates GO:0048820 ! hair follicle maturation [Term] id: GO:0048820 name: hair follicle maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol] is_a: GO:0022405 ! hair cycle process is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001942 ! hair follicle development [Term] id: GO:0048821 name: erythrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol] synonym: "RBC development" EXACT [CL:0000232] synonym: "red blood cell development" EXACT [CL:0000232] is_a: GO:0061515 ! myeloid cell development relationship: part_of GO:0030218 ! erythrocyte differentiation [Term] id: GO:0048822 name: enucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "enucleate RBC development" EXACT [CL:0000232] synonym: "enucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation [Term] id: GO:0048823 name: nucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "nucleate RBC development" EXACT [CL:0000232] synonym: "nucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation [Term] id: GO:0048824 name: pigment cell precursor differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899] synonym: "chromatophore precursor differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048825 name: cotyledon development namespace: biological_process def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] is_a: GO:0009793 ! embryo development ending in seed dormancy is_a: GO:0048366 ! leaf development [Term] id: GO:0048826 name: cotyledon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009965 ! leaf morphogenesis is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0048825 ! cotyledon development [Term] id: GO:0048827 name: phyllome development namespace: biological_process def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001] is_a: GO:0099402 ! plant organ development relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0048829 name: root cap development namespace: biological_process def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048364 ! root development [Term] id: GO:0048830 name: adventitious root development namespace: biological_process def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb] is_a: GO:0048364 ! root development [Term] id: GO:0048831 name: regulation of shoot system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392] synonym: "regulation of shoot development" EXACT [] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048367 ! shoot system development relationship: regulates GO:0048367 ! shoot system development [Term] id: GO:0048832 name: specification of plant organ number namespace: biological_process def: "The regionalization process that modulates the quantity of a particular type of plant organ." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0048833 name: specification of floral organ number namespace: biological_process def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048832 ! specification of plant organ number relationship: part_of GO:0009908 ! flower development [Term] id: GO:0048834 name: specification of petal number namespace: biological_process def: "Any process that modulates the number of petals formed in a flower." [GOC:tb] is_a: GO:0048833 ! specification of floral organ number relationship: part_of GO:0048465 ! corolla development [Term] id: GO:0048835 name: specification of decreased petal number namespace: biological_process def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb] is_a: GO:0048834 ! specification of petal number [Term] id: GO:0048836 name: specification of increased petal number namespace: biological_process def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb] is_a: GO:0048834 ! specification of petal number [Term] id: GO:0048837 name: sorocarp sorus development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp." [GOC:devbiol, GOC:mtg_sensu, PMID:4332228] synonym: "sorocarp sorus formation" EXACT [] synonym: "sorocarp spore head formation" EXACT [] synonym: "sorocarp spore head morphogenesis" RELATED [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0031154 ! culmination involved in sorocarp development [Term] id: GO:0048838 name: release of seed from dormancy namespace: biological_process def: "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830] is_a: GO:0010162 ! seed dormancy process is_a: GO:0097438 ! exit from dormancy [Term] id: GO:0048839 name: inner ear development namespace: biological_process def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043583 ! ear development [Term] id: GO:0048840 name: otolith development namespace: biological_process def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0048841 name: regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] is_a: GO:0030516 ! regulation of axon extension is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048846 ! axon extension involved in axon guidance relationship: regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048842 name: positive regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "activation of axon extension involved in axon guidance" NARROW [] synonym: "stimulation of axon extension involved in axon guidance" NARROW [] synonym: "up regulation of axon extension involved in axon guidance" EXACT [] synonym: "up-regulation of axon extension involved in axon guidance" EXACT [] synonym: "upregulation of axon extension involved in axon guidance" EXACT [] is_a: GO:0045773 ! positive regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:1902669 ! positive regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048846 ! axon extension involved in axon guidance relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048843 name: negative regulation of axon extension involved in axon guidance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] synonym: "down regulation of axon extension involved in axon guidance" EXACT [] synonym: "down-regulation of axon extension involved in axon guidance" EXACT [] synonym: "downregulation of axon extension involved in axon guidance" EXACT [] synonym: "inhibition of axon extension involved in axon guidance" NARROW [] is_a: GO:0030517 ! negative regulation of axon extension is_a: GO:0048841 ! regulation of axon extension involved in axon guidance is_a: GO:1902668 ! negative regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048846 ! axon extension involved in axon guidance relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance [Term] id: GO:0048844 name: artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] synonym: "arterial morphogenesis" EXACT [] synonym: "arteriogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060840 ! artery development [Term] id: GO:0048845 name: venous blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] synonym: "vein morphogenesis" BROAD [] synonym: "venous morphogenesis" EXACT [] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060841 ! venous blood vessel development [Term] id: GO:0048846 name: axon extension involved in axon guidance namespace: biological_process def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] is_a: GO:0048675 ! axon extension is_a: GO:1902284 ! neuron projection extension involved in neuron projection guidance intersection_of: GO:0048675 ! axon extension intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0048847 name: adenohypophysis formation namespace: biological_process def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis biosynthesis" EXACT [] synonym: "adenophysis formation" EXACT [] synonym: "anterior pituitary biosynthesis" EXACT [] synonym: "anterior pituitary formation" EXACT [] synonym: "anterior pituitary gland biosynthesis" EXACT [] synonym: "anterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048855 ! adenohypophysis morphogenesis [Term] id: GO:0048848 name: neurohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis morphogenesis" EXACT [] synonym: "posterior pituitary gland morphogenesis" EXACT [] synonym: "posterior pituitary morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0021985 ! neurohypophysis development relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048849 name: neurohypophysis formation namespace: biological_process def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis biosynthesis" EXACT [] synonym: "neurophysis formation" EXACT [] synonym: "posterior pituitary biosynthesis" EXACT [] synonym: "posterior pituitary formation" EXACT [] synonym: "posterior pituitary gland biosynthesis" EXACT [] synonym: "posterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048848 ! neurohypophysis morphogenesis [Term] id: GO:0048850 name: hypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "pituitary gland morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0021983 ! pituitary gland development relationship: part_of GO:0048852 ! diencephalon morphogenesis [Term] id: GO:0048851 name: hypophysis formation namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis biosynthesis" EXACT [] synonym: "pituitary gland biosynthesis" EXACT [] synonym: "pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048852 name: diencephalon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0048853 ! forebrain morphogenesis [Term] id: GO:0048853 name: forebrain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "prosencephalon morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030900 ! forebrain development relationship: part_of GO:0048854 ! brain morphogenesis [Term] id: GO:0048854 name: brain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007420 ! brain development [Term] id: GO:0048855 name: adenohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis morphogenesis" EXACT [] synonym: "anterior pituitary gland morphogenesis" EXACT [] synonym: "anterior pituitary morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021984 ! adenohypophysis development relationship: part_of GO:0048850 ! hypophysis morphogenesis [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process [Term] id: GO:0048857 name: neural nucleus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030030 ! cell projection organization is_a: GO:0032990 ! cell part morphogenesis relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0048859 name: formation of anatomical boundary namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0048860 name: glioblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] is_a: GO:0051301 ! cell division [Term] id: GO:0048861 name: leukemia inhibitory factor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:devbiol, GOC:signaling] synonym: "leukemia inhibitory factor signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0048863 name: stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] xref: Wikipedia:Stem_cell_differentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0048864 name: stem cell development namespace: biological_process def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] is_a: GO:0048468 ! cell development relationship: part_of GO:0048863 ! stem cell differentiation [Term] id: GO:0048865 name: stem cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0048863 ! stem cell differentiation [Term] id: GO:0048866 name: stem cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0048865 ! stem cell fate commitment [Term] id: GO:0048867 name: stem cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048865 ! stem cell fate commitment [Term] id: GO:0048868 name: pollen tube development namespace: biological_process def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009856 ! pollination [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell [Term] id: GO:0048871 name: multicellular organismal homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048873 name: homeostasis of number of cells within a tissue namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0048874 name: host-mediated regulation of intestinal microbiota composition namespace: biological_process def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [PMID:25757720] comment: Changed ter label, parent, children of this term as requested https://github.com/geneontology/go-ontology/issues/15748 synonym: "homeostasis of number of cells in a free-living population" RELATED [] synonym: "host-induced regulation of intestinal microbiota composition" RELATED [] is_a: GO:0048872 ! homeostasis of number of cells is_a: GO:0051851 ! modification by host of symbiont morphology or physiology [Term] id: GO:0048875 name: chemical homeostasis within a tissue namespace: biological_process def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0048876 name: chemical homeostasis within retina namespace: biological_process def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete] is_a: GO:0001895 ! retina homeostasis is_a: GO:0048875 ! chemical homeostasis within a tissue [Term] id: GO:0048877 name: homeostasis of number of retina cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0001895 ! retina homeostasis is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: goslim_drosophila is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048880 name: sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] is_a: GO:0048731 ! system development [Term] id: GO:0048881 name: mechanosensory lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509] synonym: "LL system development" EXACT [ISBN:0125296509] is_a: GO:0048925 ! lateral line system development [Term] id: GO:0048882 name: lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509] synonym: "LL development" EXACT [] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048883 name: neuromast primordium migration namespace: biological_process def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385] synonym: "lateral line primordium migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0048882 ! lateral line development [Term] id: GO:0048884 name: neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0048882 ! lateral line development [Term] id: GO:0048885 name: neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940] is_a: GO:0030336 ! negative regulation of cell migration relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048886 name: neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0042490 ! mechanoreceptor differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048887 name: cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048888 name: neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048889 name: neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048884 ! neuromast development [Term] id: GO:0048890 name: lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gLL ganglion development" EXACT [] is_a: GO:0061550 ! cranial ganglion development relationship: part_of GO:0007422 ! peripheral nervous system development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048891 name: lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940] synonym: "gLL neuron differentiation" EXACT [] is_a: GO:0048934 ! peripheral nervous system neuron differentiation relationship: part_of GO:0048890 ! lateral line ganglion development [Term] id: GO:0048892 name: lateral line nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509] synonym: "nLL development" EXACT [] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0048925 ! lateral line system development [Term] id: GO:0048893 name: afferent axon development in lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385] is_a: GO:0061564 ! axon development relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048894 name: efferent axon development in a lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385] is_a: GO:0021955 ! central nervous system neuron axonogenesis relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048895 name: lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048896 name: lateral line nerve glial cell migration namespace: biological_process def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041] synonym: "glial cell migration in lateral line nerve" EXACT [] is_a: GO:0008347 ! glial cell migration relationship: part_of GO:0048892 ! lateral line nerve development [Term] id: GO:0048897 name: myelination of lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375] is_a: GO:0042552 ! myelination relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048898 name: anterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "ALL system development" RELATED [] is_a: GO:0048925 ! lateral line system development relationship: part_of GO:0048881 ! mechanosensory lateral line system development [Term] id: GO:0048899 name: anterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "anterior LL development" EXACT [] is_a: GO:0048882 ! lateral line development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048900 name: anterior lateral line neuromast primordium migration namespace: biological_process def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] synonym: "ALL neuromast primordium migration" EXACT [] is_a: GO:0048883 ! neuromast primordium migration relationship: part_of GO:0048899 ! anterior lateral line development [Term] id: GO:0048901 name: anterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development relationship: part_of GO:0048899 ! anterior lateral line development [Term] id: GO:0048902 name: anterior lateral line neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385] is_a: GO:0048885 ! neuromast deposition relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048903 name: anterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377] is_a: GO:0048886 ! neuromast hair cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048904 name: anterior lateral line neuromast cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048887 ! cupula development relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048905 name: anterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048906 name: anterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation relationship: part_of GO:0048901 ! anterior lateral line neuromast development [Term] id: GO:0048907 name: anterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] synonym: "gALL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048908 name: anterior lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940] is_a: GO:0048891 ! lateral line ganglion neuron differentiation relationship: part_of GO:0048907 ! anterior lateral line ganglion development [Term] id: GO:0048909 name: anterior lateral line nerve development namespace: biological_process alt_id: GO:0021734 def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509] comment: This term was added by GO_REF:0000021. synonym: "ALLN development" EXACT [] synonym: "nALL development" EXACT [] synonym: "rostral lateral line nerve development" EXACT [] is_a: GO:0048892 ! lateral line nerve development relationship: part_of GO:0048898 ! anterior lateral line system development [Term] id: GO:0048910 name: afferent axon development in anterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940] is_a: GO:0048893 ! afferent axon development in lateral line nerve relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048911 name: efferent axon development in anterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940] is_a: GO:0048894 ! efferent axon development in a lateral line nerve relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048912 name: glial cell migration in anterior lateral line nerve namespace: biological_process def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041] is_a: GO:0048896 ! lateral line nerve glial cell migration relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048913 name: anterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation relationship: part_of GO:0048909 ! anterior lateral line nerve development [Term] id: GO:0048914 name: myelination of anterior lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375] is_a: GO:0048897 ! myelination of lateral line nerve axons relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048915 name: posterior lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] synonym: "PLL" RELATED [] is_a: GO:0048925 ! lateral line system development relationship: part_of GO:0048881 ! mechanosensory lateral line system development [Term] id: GO:0048916 name: posterior lateral line development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509] synonym: "PLL development" EXACT [] is_a: GO:0048882 ! lateral line development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048917 name: posterior lateral line ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377] synonym: "gPLL development" EXACT [] is_a: GO:0048890 ! lateral line ganglion development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048918 name: posterior lateral line nerve development namespace: biological_process alt_id: GO:0021733 def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509] comment: This term was added by GO_REF:0000021. synonym: "caudal lateral line nerve development" EXACT [] synonym: "PLLN development" EXACT [] is_a: GO:0048892 ! lateral line nerve development relationship: part_of GO:0048915 ! posterior lateral line system development [Term] id: GO:0048919 name: posterior lateral line neuromast development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] is_a: GO:0048884 ! neuromast development relationship: part_of GO:0048916 ! posterior lateral line development [Term] id: GO:0048920 name: posterior lateral line neuromast primordium migration namespace: biological_process def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] synonym: "PLL neuromast primordium migration" EXACT [] is_a: GO:0048883 ! neuromast primordium migration relationship: part_of GO:0048916 ! posterior lateral line development [Term] id: GO:0048921 name: posterior lateral line neuromast cupula development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] is_a: GO:0048887 ! cupula development relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048922 name: posterior lateral line neuromast deposition namespace: biological_process def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385] is_a: GO:0048885 ! neuromast deposition relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048923 name: posterior lateral line neuromast hair cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] is_a: GO:0048886 ! neuromast hair cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048924 name: posterior lateral line neuromast mantle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] is_a: GO:0048888 ! neuromast mantle cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048925 name: lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509] is_a: GO:0048880 ! sensory system development [Term] id: GO:0048926 name: electrosensory lateral line system development namespace: biological_process def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh] is_a: GO:0048925 ! lateral line system development [Term] id: GO:0048927 name: posterior lateral line neuromast support cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] is_a: GO:0048889 ! neuromast support cell differentiation relationship: part_of GO:0048919 ! posterior lateral line neuromast development [Term] id: GO:0048928 name: posterior lateral line ganglion neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940] is_a: GO:0048891 ! lateral line ganglion neuron differentiation relationship: part_of GO:0048917 ! posterior lateral line ganglion development [Term] id: GO:0048929 name: efferent axon development in posterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940] is_a: GO:0048894 ! efferent axon development in a lateral line nerve relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048930 name: glial cell migration in posterior lateral line nerve namespace: biological_process def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041] is_a: GO:0048896 ! lateral line nerve glial cell migration relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048931 name: posterior lateral line nerve glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385] is_a: GO:0048895 ! lateral line nerve glial cell differentiation relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048932 name: myelination of posterior lateral line nerve axons namespace: biological_process def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375] is_a: GO:0048897 ! myelination of lateral line nerve axons relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation [Term] id: GO:0048933 name: afferent axon development in posterior lateral line nerve namespace: biological_process def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940] is_a: GO:0048893 ! afferent axon development in lateral line nerve relationship: part_of GO:0048918 ! posterior lateral line nerve development [Term] id: GO:0048934 name: peripheral nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0048935 name: peripheral nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] is_a: GO:0048666 ! neuron development relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation [Term] id: GO:0048936 name: peripheral nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh] is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0048935 ! peripheral nervous system neuron development [Term] id: GO:0048937 name: lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation [Term] id: GO:0048938 name: lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] is_a: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: part_of GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048937 ! lateral line nerve glial cell development [Term] id: GO:0048939 name: anterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation [Term] id: GO:0048940 name: anterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: part_of GO:0048939 ! anterior lateral line nerve glial cell development relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development [Term] id: GO:0048941 name: posterior lateral line nerve glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] is_a: GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation [Term] id: GO:0048942 name: posterior lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: part_of GO:0048941 ! posterior lateral line nerve glial cell development relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0050001 name: D-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN] synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35] xref: EC:3.5.1.35 xref: MetaCyc:D-GLUTAMINASE-RXN xref: RHEA:22840 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050002 name: D-proline reductase (dithiol) activity namespace: molecular_function def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN] comment: Note that this function was formerly EC:1.4.4.1. synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1] xref: EC:1.21.4.1 xref: MetaCyc:1.21.4.1-RXN xref: RHEA:12737 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0050003 name: deoxycytidylate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11568] synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54] synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54] xref: EC:2.1.1.54 xref: KEGG_REACTION:R01670 xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN xref: RHEA:11568 is_a: GO:0008169 ! C-methyltransferase activity [Term] id: GO:0050004 name: isoflavone 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] xref: EC:2.4.1.170 xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050005 name: isohexenylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O." [EC:4.2.1.57, RHEA:24144] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57] synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57] synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57] synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57] synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57] xref: EC:4.2.1.57 xref: KEGG_REACTION:R03493 xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN xref: RHEA:24144 xref: UM-BBD_reactionID:r1167 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050006 name: isomaltulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN] synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11] synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11] synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11] synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11] xref: EC:5.4.99.11 xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN xref: RHEA:24032 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050007 name: isonocardicin synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A." [EC:2.5.1.38, RHEA:19845] synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38] synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38] xref: EC:2.5.1.38 xref: KEGG_REACTION:R03072 xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN xref: RHEA:19845 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050008 name: isopiperitenone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, RHEA:21516] synonym: "isopiperitenone D-isomerase activity" EXACT [] synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11] xref: EC:5.3.3.11 xref: KEGG_REACTION:R03782 xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN xref: RHEA:21516 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050009 name: isopropanol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH." [EC:1.1.1.80, RHEA:21792] synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80] xref: EC:1.1.1.80 xref: KEGG_REACTION:R01550 xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN xref: RHEA:21792 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050010 name: isovitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19529] synonym: "isovitexin b-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106] xref: EC:2.4.1.106 xref: KEGG_REACTION:R03686 xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:19529 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050011 name: itaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN] synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56] synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56] synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56] xref: EC:4.2.1.56 xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN xref: RHEA:13785 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050012 name: juglone 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + AH(2) + O(2) = 3,5-dihydroxy-1,4-naphthoquinone + A + H(2)O + H(+)." [EC:1.14.99.27, RHEA:18745] synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27] synonym: "juglone hydroxylase activity" EXACT [] synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27] synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27] xref: EC:1.14.99.27 xref: KEGG_REACTION:R04327 xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN xref: RHEA:18745 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050013 name: 2-dehydropantoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN] synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12] synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12] synonym: "ketopantoaldolase activity" EXACT [] xref: EC:4.1.2.12 xref: MetaCyc:KETOPANTOALDOLASE-RXN xref: RHEA:23276 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050014 name: ketotetrose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20932] synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2] synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2] synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2] xref: EC:4.1.2.2 xref: KEGG_REACTION:R01014 xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN xref: RHEA:20932 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050015 name: kievitone hydratase activity namespace: molecular_function def: "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone." [EC:4.2.1.95, RHEA:23604] synonym: "KHase activity" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95] synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95] xref: EC:4.2.1.95 xref: KEGG_REACTION:R03622 xref: MetaCyc:KIEVITONE-HYDRATASE-RXN xref: RHEA:23604 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050016 name: kynurenine 7,8-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN] synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2] synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2] synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2] xref: EC:1.14.99.2 xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN xref: RHEA:11968 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050017 name: L-3-cyanoalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN] synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9] synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9] synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9] xref: EC:4.4.1.9 xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN xref: RHEA:17821 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050018 name: L-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN] synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5] xref: EC:1.4.1.5 xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN xref: RHEA:10396 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050019 name: L-arabinitol 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH." [EC:1.1.1.12, RHEA:16381] xref: EC:1.1.1.12 xref: KEGG_REACTION:R01903 xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN xref: RHEA:16381 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050020 name: L-arabinonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O." [EC:4.2.1.25, RHEA:20968] synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25] synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25] synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25] xref: EC:4.2.1.25 xref: KEGG_REACTION:R02522 xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN xref: RHEA:20968 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050021 name: L-arabinonolactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+)." [EC:3.1.1.15, RHEA:16217] synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15] xref: EC:3.1.1.15 xref: KEGG_REACTION:R02526 xref: MetaCyc:L-ARABINONOLACTONASE-RXN xref: RHEA:16217 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050022 name: L-arabinose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "L-arabinose 1-dehydrogenase activity" BROAD [] synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46] xref: EC:1.1.1.46 xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN xref: RHEA:17925 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050023 name: L-fuconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O." [EC:4.2.1.68, RHEA:22772] synonym: "L-fuconate hydratase activity" EXACT [] synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68] synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68] xref: EC:4.2.1.68 xref: KEGG_REACTION:R03688 xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN xref: RHEA:22772 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050024 name: L-galactonolactone oxidase activity namespace: molecular_function alt_id: GO:0033733 def: "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+)." [EC:1.3.3.12, RHEA:20617] synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12] synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] xref: EC:1.3.3.12 xref: KEGG_REACTION:R00643 xref: MetaCyc:1.3.3.12-RXN xref: RHEA:20617 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050025 name: L-glutamate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN] synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11] synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11] synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11] synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11] synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11] xref: EC:1.4.3.11 xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN xref: RHEA:20728 is_a: GO:0001716 ! L-amino-acid oxidase activity [Term] id: GO:0050026 name: L-glycol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN] synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185] synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185] xref: EC:1.1.1.185 xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050027 name: obsolete L-idonate 2-dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN] comment: This term was made obsolete because EC:1.1.1.128 was deleted: the reaction described is covered by EC 1.1.1.264. synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128] synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128] synonym: "5KGR" RELATED [EC:1.1.1.128] synonym: "L-idonate 2-dehydrogenase activity" EXACT [] synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128] synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128] synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128] xref: EC:1.1.1.128 xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN xref: RHEA:21176 is_obsolete: true consider: GO:0050572 [Term] id: GO:0050028 name: L-lysine-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine." [EC:3.5.2.11, RHEA:21388] synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11] synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11] synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11] xref: EC:3.5.2.11 xref: KEGG_REACTION:R00463 xref: MetaCyc:L-LYSINE-LACTAMASE-RXN xref: RHEA:21388 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050029 name: L-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+)." [EC:1.4.3.14, RHEA:14437] synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14] synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14] synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14] xref: EC:1.4.3.14 xref: KEGG_REACTION:R00447 xref: MetaCyc:L-LYSINE-OXIDASE-RXN xref: MetaCyc:PWY-5311 xref: RHEA:14437 is_a: GO:0001716 ! L-amino-acid oxidase activity [Term] id: GO:0050030 name: L-pipecolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN] synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] xref: EC:1.5.99.3 xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN xref: RHEA:19777 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050031 name: L-pipecolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11992] synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7] synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7] xref: EC:1.5.3.7 xref: KEGG_REACTION:R02204 xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN xref: Reactome:R-HSA-6783880 "PIPOX oxidises PPCA to P6C" xref: RHEA:11992 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050032 name: L-rhamnonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O." [EC:4.2.1.90, RHEA:23080] synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90] synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90] xref: EC:4.2.1.90 xref: KEGG_REACTION:R03774 xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN xref: RHEA:23080 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050033 name: L-rhamnono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+)." [EC:3.1.1.65, RHEA:10288] synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65] synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65] xref: EC:3.1.1.65 xref: KEGG_REACTION:R03772 xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN xref: RHEA:10288 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050034 name: L-rhamnose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH." [EC:1.1.1.173, RHEA:12649] synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173] xref: EC:1.1.1.173 xref: KEGG_REACTION:R03942 xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN xref: RHEA:12649 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050035 name: L-sorbose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2)." [EC:1.1.3.11, RHEA:17853] synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11] xref: EC:1.1.3.11 xref: KEGG_REACTION:R01695 xref: MetaCyc:L-SORBOSE-OXIDASE-RXN xref: RHEA:17853 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050036 name: L-threonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH." [EC:1.1.1.129, RHEA:23376] synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129] synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129] synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129] xref: EC:1.1.1.129 xref: KEGG_REACTION:R03733 xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN xref: RHEA:23376 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050037 name: L-xylose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH." [EC:1.1.1.113, RHEA:15789] synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113] synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113] synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113] xref: EC:1.1.1.113 xref: KEGG_REACTION:R03586 xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN xref: RHEA:15789 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050038 name: L-xylulose reductase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17025] synonym: "L-xylulose reductase activity" BROAD [] xref: EC:1.1.1.10 xref: KEGG_REACTION:R01904 xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN xref: Reactome:R-HSA-5661240 "DCXR tetramer reduces L-xylulose to xylitol" xref: Reactome:R-HSA-5662851 "Defective DCXR does not reduce L-xylulose to xylitol" xref: RHEA:17025 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050039 name: lactaldehyde reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH." [EC:1.1.1.55, RHEA:15885] synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55] synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] xref: EC:1.1.1.55 xref: KEGG_REACTION:R02259 xref: MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN xref: RHEA:15885 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050040 name: lactate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O." [EC:1.13.12.4, RHEA:16513] synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4] synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4] synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4] synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4] xref: EC:1.13.12.4 xref: KEGG_REACTION:R00319 xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN xref: RHEA:16513 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050041 name: lactate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate." [EC:4.1.2.36, RHEA:17909] synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36] synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36] synonym: "lactate synthase activity" EXACT [EC:4.1.2.36] xref: EC:4.1.2.36 xref: KEGG_REACTION:R00753 xref: MetaCyc:LACTATE-ALDOLASE-RXN xref: RHEA:17909 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050042 name: lactate-malate transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10984] synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7] synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7] xref: EC:1.1.99.7 xref: KEGG_REACTION:R01447 xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN xref: RHEA:10984 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050043 name: lactate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, RHEA:10960] synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1] synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1] synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1] xref: EC:5.1.2.1 xref: KEGG_REACTION:R01450 xref: MetaCyc:LACTATE-RACEMASE-RXN xref: RHEA:10960 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0050044 name: galactose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13033] synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26] synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26] xref: EC:5.3.1.26 xref: KEGG_REACTION:R03240 xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN xref: RHEA:13033 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050045 name: laminaribiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN] synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31] xref: EC:2.4.1.31 xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN xref: RHEA:16617 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050046 name: lathosterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN] synonym: "5-DES" RELATED [EC:1.14.21.6] synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6] synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6] synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6] xref: EC:1.14.21.6 xref: MetaCyc:1.14.21.6-RXN is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0050047 name: leucine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine = (3R)-beta-leucine." [EC:5.4.3.7, RHEA:10284] synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7] xref: EC:5.4.3.7 xref: KEGG_REACTION:R01091 xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN xref: RHEA:10284 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0050048 name: L-leucine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN] synonym: "L-leucine aminotransferase activity" BROAD [EC:2.6.1.6] synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6] synonym: "leucine aminotransferase activity" BROAD [] synonym: "leucine transaminase activity" BROAD [EC:2.6.1.6] synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6] xref: EC:2.6.1.6 xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN xref: RHEA:18321 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050049 name: leucine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN] synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9] synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9] synonym: "LeuDH activity" EXACT [EC:1.4.1.9] xref: EC:1.4.1.9 xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN xref: RHEA:12220 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050050 name: leucine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)." [EC:2.3.1.66, RHEA:20089] synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66] synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66] xref: EC:2.3.1.66 xref: KEGG_REACTION:R01089 xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:20089 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0050051 name: leukotriene-B4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30] synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] synonym: "leukotriene-B4 20-hydroxylase activity" EXACT [] {comment="EC:1.14.14.94"} synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.14.94] synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.14.94] synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.14.94] synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.14.94] synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.14.94] xref: EC:1.14.14.94 xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN xref: Reactome:R-HSA-211873 "CYP4F2, 4F3 20-hydroxylate LTB4" xref: RHEA:22176 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen relationship: part_of GO:0036101 ! leukotriene B4 catabolic process [Term] id: GO:0050052 name: leukotriene-E4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+)." [EC:1.14.13.34, RHEA:24120] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34] synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34] synonym: "leukotriene-E4 w-hydroxylase activity" EXACT [] xref: EC:1.14.13.34 xref: KEGG_REACTION:R04256 xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN xref: RHEA:24120 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050053 name: levansucrase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN] synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10] xref: EC:2.4.1.10 xref: MetaCyc:LEVANSUCRASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050054 name: lignostilbene alpha beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin." [EC:1.13.11.43, RHEA:21340] synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43] synonym: "lignostilbene ab-dioxygenase activity" EXACT [] synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43] xref: EC:1.13.11.43 xref: KEGG_REACTION:R00043 xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN xref: RHEA:21340 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050055 name: limonin-D-ring-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN] synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36] synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36] xref: EC:3.1.1.36 xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN xref: RHEA:10896 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050056 name: linalool 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O." [EC:1.14.99.28, RHEA:20760] synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28] xref: EC:1.14.99.28 xref: KEGG_REACTION:R04366 xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN xref: RHEA:20760 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050057 name: linamarin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN] synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63] xref: EC:2.4.1.63 xref: MetaCyc:LINAMARIN-SYNTHASE-RXN xref: RHEA:20009 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050058 name: linoleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, RHEA:17381] synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5] synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5] xref: EC:5.2.1.5 xref: KEGG_REACTION:R03627 xref: MetaCyc:LINOLEATE-ISOMERASE-RXN xref: RHEA:17381 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050059 name: lombricine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN] synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5] xref: EC:2.7.3.5 xref: MetaCyc:LOMBRICINE-KINASE-RXN xref: RHEA:23292 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050060 name: long-chain-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN] synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192] synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192] synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192] xref: EC:1.1.1.192 xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050061 name: long-chain-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN] synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] xref: EC:1.2.1.48 xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r1404 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0050062 name: long-chain-fatty-acyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50] synonym: "long-chain fatty acyl CoA reductase activity" EXACT [] synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50] xref: EC:1.2.1.50 xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050063 name: obsolete low-density-lipoprotein particle receptor kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN] comment: This term was made obsolete because it represents a specific gene product. synonym: "[low-density lipoprotein receptor] kinase activity" EXACT [] synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29] synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29] synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29] synonym: "low-density-lipoprotein receptor kinase activity" EXACT [GOC:dph] synonym: "STK7" RELATED [EC:2.7.11.29] xref: EC:2.7.11.29 xref: MetaCyc:2.7.11.29-RXN is_obsolete: true [Term] id: GO:0050064 name: luteolin 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10568] synonym: "LGT" RELATED [EC:2.4.1.189] synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT [] synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] xref: EC:2.4.1.189 xref: KEGG_REACTION:R03589 xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN xref: RHEA:10568 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050065 name: lysine-pyruvate 6-transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19393] synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] synonym: "Lys-AT" RELATED [EC:2.6.1.71] synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT [] synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] xref: EC:2.6.1.71 xref: KEGG_REACTION:R00453 xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN xref: MetaCyc:PWY-5324 xref: RHEA:19393 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050066 name: lysine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, RHEA:19177] synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2] xref: EC:5.4.3.2 xref: KEGG_REACTION:R00461 xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN xref: RHEA:19177 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0050067 name: lysine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O." [EC:1.13.12.2, RHEA:14601] synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2] synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2] synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2] xref: EC:1.13.12.2 xref: KEGG_REACTION:R00449 xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN xref: RHEA:14601 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050068 name: lysine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate." [EC:2.1.3.8, RHEA:17121] synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8] synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8] xref: EC:2.1.3.8 xref: KEGG_REACTION:R01396 xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:17121 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050069 name: lysine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN] synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15] xref: EC:1.4.1.15 xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN xref: RHEA:18505 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050070 name: lysolecithin acylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24356] synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1] synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1] xref: EC:5.4.1.1 xref: KEGG_REACTION:R03334 xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN xref: RHEA:24356 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0050071 name: lysyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN] synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3] synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3] xref: EC:2.3.2.3 xref: MetaCyc:LYSYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0050072 name: m7G(5')pppN diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN] synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30] synonym: "decapase activity" RELATED [EC:3.6.1.30] synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30] xref: EC:3.6.1.30 xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050073 name: macrolide 2'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18333] synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136] xref: EC:2.7.1.136 xref: KEGG_REACTION:R03780 xref: MetaCyc:MACROLIDE-2-KINASE-RXN xref: RHEA:18333 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050074 name: malate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN] synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9] synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9] synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9] synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9] xref: EC:6.2.1.9 xref: MetaCyc:MALATE--COA-LIGASE-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050075 name: maleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-malate = H(2)O + maleate." [EC:4.2.1.31, RHEA:23692] synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31] synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31] synonym: "malease activity" EXACT [EC:4.2.1.31] xref: EC:4.2.1.31 xref: KEGG_REACTION:R02419 xref: MetaCyc:MALEATE-HYDRATASE-RXN xref: RHEA:23692 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050076 name: maleate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, RHEA:13169] synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1] xref: EC:5.2.1.1 xref: KEGG_REACTION:R01087 xref: MetaCyc:MALEATE-ISOMERASE-RXN xref: RHEA:13169 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050077 name: maleylpyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN] synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4] xref: EC:5.2.1.4 xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN xref: RHEA:17393 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050078 name: malonate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18817] synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3] synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3] xref: EC:2.8.3.3 xref: KEGG_REACTION:R00743 xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN xref: RHEA:18817 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0050079 name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate namespace: molecular_function alt_id: GO:0047607 def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN] comment: Note that this function was formerly EC:4.2.1.71. synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27] synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT [] synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27] synonym: "alkynoate hydratase activity" BROAD [] synonym: "malonate-semialdehyde dehydratase activity" EXACT [] xref: EC:4.2.1.27 xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN xref: RHEA:17957 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050080 name: malonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN] synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9] synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9] xref: EC:4.1.1.9 xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN xref: Reactome:R-HSA-977317 "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome" xref: RHEA:18781 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050081 name: maltose-6'-phosphate glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN] synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122] synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122] xref: EC:3.2.1.122 xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN xref: RHEA:20421 is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0050082 name: maltose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN] synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8] xref: EC:2.4.1.8 xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN xref: RHEA:21116 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0050083 name: malyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24] synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24] synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24] xref: EC:4.1.3.24 xref: MetaCyc:MALYL-COA-LYASE-RXN xref: RHEA:16629 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0050084 name: mannitol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate." [EC:3.1.3.22, RHEA:19537] synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22] synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22] xref: EC:3.1.3.22 xref: KEGG_REACTION:R02167 xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN xref: RHEA:19537 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050085 name: mannitol 2-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH." [EC:1.1.1.138, RHEA:16765] synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138] synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138] xref: EC:1.1.1.138 xref: KEGG_REACTION:R00870 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN xref: RHEA:16765 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050086 name: mannitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN] synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67] synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67] xref: EC:1.1.1.67 xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN xref: RHEA:12084 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050087 name: mannitol dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN] synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] xref: EC:1.1.2.2 xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0050088 name: mannose-6-phosphate 6-reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH." [EC:1.1.1.224, RHEA:14925] synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224] synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224] synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224] xref: EC:1.1.1.224 xref: KEGG_REACTION:R01817 xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN xref: RHEA:14925 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050089 name: mannose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, RHEA:22604] synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7] synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7] xref: EC:5.3.1.7 xref: KEGG_REACTION:R00877 xref: MetaCyc:MANNOSE-ISOMERASE-RXN xref: RHEA:22604 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050090 name: mannuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN] synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131] synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131] synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131] synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131] xref: EC:1.1.1.131 xref: MetaCyc:MANNURONATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050091 name: melilotate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)." [EC:1.14.13.4, RHEA:17669] synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4] synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4] synonym: "melilotate hydroxylase activity" EXACT [] synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4] xref: EC:1.14.13.4 xref: KEGG_REACTION:R03369 xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN xref: RHEA:17669 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050092 name: meso-tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." [EC:1.3.1.7, RHEA:18553] synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7] xref: EC:1.3.1.7 xref: KEGG_REACTION:R02544 xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN xref: RHEA:18553 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050093 name: methanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19401] synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244] xref: EC:1.1.1.244 xref: KEGG_REACTION:R00605 xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN xref: RHEA:19401 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050094 name: methionine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22884] synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] synonym: "MGAT activity" EXACT [EC:2.6.1.73] xref: EC:2.6.1.73 xref: KEGG_REACTION:R00652 xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN xref: RHEA:22884 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050095 name: methionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2)." [EC:4.1.1.57, RHEA:17757] synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57] synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57] synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57] xref: EC:4.1.1.57 xref: KEGG_REACTION:R00656 xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN xref: RHEA:17757 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050096 name: methylaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+)." [EC:4.3.1.2, RHEA:12829] synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2] synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2] xref: EC:4.3.1.2 xref: KEGG_REACTION:R03696 xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN xref: RHEA:12829 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0050097 name: methylaspartate mutase activity namespace: molecular_function def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate." [EC:5.4.99.1, RHEA:12857] synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1] synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1] synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1] synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1] synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1] xref: EC:5.4.99.1 xref: KEGG_REACTION:R00262 xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN xref: RHEA:12857 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050098 name: methylguanidinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11764] synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16] synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16] xref: EC:3.5.3.16 xref: KEGG_REACTION:R01589 xref: MetaCyc:METHYLGUANIDINASE-RXN xref: RHEA:11764 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050099 name: methylglutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22572] synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5] xref: EC:1.5.99.5 xref: KEGG_REACTION:R00609 xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN xref: RHEA:22572 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050100 name: methylitaconate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [EC:5.3.3.6, RHEA:23480] synonym: "methylitaconate D-isomerase activity" EXACT [] synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6] synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6] xref: EC:5.3.3.6 xref: KEGG_REACTION:R03070 xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN xref: RHEA:23480 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050101 name: mimosinase activity namespace: molecular_function def: "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, RHEA:13373] synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61] xref: EC:3.5.1.61 xref: KEGG_REACTION:R04350 xref: MetaCyc:MIMOSINASE-RXN xref: RHEA:13373 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050102 name: cellodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN] synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49] synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49] xref: EC:2.4.1.49 xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050103 name: dextrin dextranase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN] synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2] synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2] synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2] xref: EC:2.4.1.2 xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050104 name: L-gulonate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH." [EC:1.1.1.45, RHEA:12889] synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45] synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45] xref: EC:1.1.1.45 xref: KEGG_REACTION:R02640 xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN xref: Reactome:R-HSA-5661290 "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate" xref: RHEA:12889 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050105 name: L-gulonolactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN] synonym: "GLO activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8] synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8] xref: EC:1.1.3.8 xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN xref: RHEA:25083 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050106 name: monomethyl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate." [EC:3.1.6.16, RHEA:14221] synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16] synonym: "monomethyl-sulphatase activity" EXACT [] xref: EC:3.1.6.16 xref: KEGG_REACTION:R01145 xref: MetaCyc:MONOMETHYL-SULFATASE-RXN xref: RHEA:14221 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0050107 name: monoterpenol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69] synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69] xref: EC:2.3.1.69 xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050108 name: monoterpenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN] synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3] synonym: "monoterpenyl-pyrophosphatase activity" EXACT [] xref: EC:3.1.7.3 xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0050109 name: morphine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN] synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218] synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218] synonym: "reductase, naloxone" EXACT [EC:1.1.1.218] xref: EC:1.1.1.218 xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050110 name: mucinaminylserine mucinaminidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [MetaCyc:3.2.1.110-RXN] synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110] synonym: "endo-beta-N-acetyl-D-galactosaminidase activity" BROAD [EC:3.2.1.110] synonym: "endo-beta-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110] xref: EC:3.2.1.97 xref: KEGG_REACTION:R04527 xref: MetaCyc:3.2.1.110-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050111 name: mycocerosate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10588] synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111] synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111] xref: EC:2.3.1.111 xref: KEGG_REACTION:R05189 xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN xref: RHEA:10588 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050112 name: inositol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16949] synonym: "inositol:NAD 2-dehydrogenase activity" EXACT [] synonym: "myo-inositol 2-dehydrogenase activity" EXACT [] xref: EC:1.1.1.18 xref: KEGG_REACTION:R01183 xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN xref: RHEA:16949 is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity [Term] id: GO:0050113 name: inositol oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23696] synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1] synonym: "MOO activity" EXACT [EC:1.13.99.1] synonym: "myo-inositol oxygenase activity" EXACT [] synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1] xref: EC:1.13.99.1 xref: KEGG_REACTION:R01184 xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN xref: Reactome:R-HSA-5678327 "MIOX oxidises Ins to GlcA" xref: RHEA:23696 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0050114 name: myo-inosose-2 dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O." [EC:4.2.1.44, RHEA:14065] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44] synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44] synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44] synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44] xref: EC:4.2.1.44 xref: KEGG_REACTION:R02782 xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN xref: RHEA:14065 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050115 name: myosin-light-chain-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN] synonym: "[Myosin light-chain]-phosphatase activity" EXACT [] synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53] synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53] synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53] synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53] xref: EC:3.1.3.53 xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN xref: Reactome:R-HSA-419232 "Myosin phosphatase dephosphorylates myosin regulatory light chain" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0050116 name: N,N-dimethylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19517] synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56] synonym: "DMFase activity" EXACT [EC:3.5.1.56] synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56] xref: EC:3.5.1.56 xref: KEGG_REACTION:R02509 xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN xref: RHEA:19517 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050117 name: N-acetyl-beta-alanine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23212] synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21] xref: EC:3.5.1.21 xref: KEGG_REACTION:R00909 xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN xref: RHEA:23212 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050118 name: N-acetyldiaminopimelate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate." [EC:3.5.1.47, RHEA:20405] synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47] synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47] synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] xref: EC:3.5.1.47 xref: KEGG_REACTION:R02733 xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN xref: RHEA:20405 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050119 name: N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20593] synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33] synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33] xref: EC:3.5.1.33 xref: KEGG_REACTION:R01200 xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN xref: Reactome:R-HSA-2022887 "NDST1-4 N-deacetylates GlcNAc residues in heparan" xref: RHEA:20593 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0050120 name: N-acetylhexosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH." [EC:1.1.1.240, RHEA:23144] synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240] synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] xref: EC:1.1.1.240 xref: KEGG_REACTION:R01202 xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN xref: RHEA:23144 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050121 name: N-acylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN] synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] xref: EC:5.1.3.8 xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN xref: Reactome:R-HSA-6803761 "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc" xref: RHEA:19033 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050122 name: N-acylhexosamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+)." [EC:1.1.3.29, RHEA:13029] synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29] synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] xref: EC:1.1.3.29 xref: KEGG_REACTION:R01203 xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN xref: RHEA:13029 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050123 name: N-acylmannosamine 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH." [EC:1.1.1.233, RHEA:11540] synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233] synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] xref: EC:1.1.1.233 xref: KEGG_REACTION:R02651 xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN xref: RHEA:11540 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050124 name: N-acylneuraminate-9-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN] synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29] synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29] xref: EC:3.1.3.29 xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN xref: Reactome:R-HSA-4084989 "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac" xref: RHEA:13057 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050125 name: N-benzyloxycarbonylglycine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine." [EC:3.5.1.58, RHEA:20900] synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58] synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58] synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58] synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58] xref: EC:3.5.1.58 xref: KEGG_REACTION:R02551 xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN xref: RHEA:20900 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050126 name: N-carbamoylputrescine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine." [EC:3.5.1.53, RHEA:22284] synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53] synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53] synonym: "NCP" RELATED [EC:3.5.1.53] xref: EC:3.5.1.53 xref: KEGG_REACTION:R01152 xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN xref: RHEA:22284 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050127 name: N-carbamoylsarcosine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine." [EC:3.5.1.59, RHEA:20057] synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59] synonym: "CSHase activity" EXACT [EC:3.5.1.59] synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59] xref: EC:3.5.1.59 xref: KEGG_REACTION:R01563 xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN xref: RHEA:20057 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050128 name: N-feruloylglycine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine." [EC:3.5.1.71, RHEA:10484] synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71] synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71] xref: EC:3.5.1.71 xref: KEGG_REACTION:R03579 xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN xref: RHEA:10484 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050129 name: N-formylglutamate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12476] synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68] synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68] synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68] synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68] synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68] xref: EC:3.5.1.68 xref: KEGG_REACTION:R00525 xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN xref: RHEA:12476 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050130 name: N-methyl-2-oxoglutaramate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24108] synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36] synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36] xref: EC:3.5.1.36 xref: KEGG_REACTION:R01587 xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN xref: RHEA:24108 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050131 name: N-methyl-L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN] synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2] synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2] xref: EC:1.5.3.2 xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050132 name: N-methylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21768] synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17] xref: EC:1.4.1.17 xref: KEGG_REACTION:R01584 xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN xref: RHEA:21768 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050133 name: N6-hydroxylysine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22388] synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102] xref: EC:2.3.1.102 xref: KEGG_REACTION:R03168 xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN xref: RHEA:22388 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050134 name: N6-methyl-lysine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2)." [EC:1.5.3.4, RHEA:23200] synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4] synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4] synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4] synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4] xref: EC:1.5.3.4 xref: KEGG_REACTION:R00612 xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN xref: RHEA:23200 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0050135 name: NAD(P)+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN] synonym: "NAD(P) nucleosidase activity" EXACT [] synonym: "NAD(P)(+) nucleosidase activity" EXACT [] synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6] synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6] synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6] xref: EC:3.2.2.6 xref: MetaCyc:NADP+-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0050136 name: NADH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.5.11, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN] synonym: "D-diaphorase activity" EXACT [EC:1.6.5.11] synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.5.11] synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.5.11] synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.5.11] synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5] xref: EC:1.6.5.11 xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN xref: RHEA:46160 is_a: GO:0003954 ! NADH dehydrogenase activity is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0050137 name: NADPH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+)." [EC:1.11.1.2, RHEA:15173] synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2] synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2] synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2] synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2] synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2] xref: EC:1.11.1.2 xref: KEGG_REACTION:R00113 xref: MetaCyc:NADPH-PEROXIDASE-RXN xref: RHEA:15173 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0050138 name: nicotinate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH." [EC:1.17.1.5, RHEA:12236] synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5] synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5] synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5] xref: EC:1.17.1.5 xref: KEGG_REACTION:R01720 xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN xref: MetaCyc:RXN-7637 xref: RHEA:12236 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0050139 name: nicotinate-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19437] synonym: "nicotinate glucosyltransferase activity" BROAD [] synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] xref: EC:2.4.1.196 xref: KEGG_REACTION:R01722 xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN xref: RHEA:19437 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050140 name: nitrate reductase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN] synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1] synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1] xref: EC:1.9.6.1 xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor [Term] id: GO:0050141 name: nitroethane oxidase activity namespace: molecular_function def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN] synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1] synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] xref: EC:1.7.3.1 xref: MetaCyc:NITROETHANE-OXIDASE-RXN is_a: GO:0052664 ! nitroalkane oxidase activity [Term] id: GO:0050142 name: nitrogenase (flavodoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN] synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1] xref: EC:1.19.6.1 xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor [Term] id: GO:0050143 name: nocardicin-A epimerase activity namespace: molecular_function def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, RHEA:22792] synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14] xref: EC:5.1.1.14 xref: KEGG_REACTION:R03073 xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN xref: RHEA:22792 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0050144 name: nucleoside deoxyribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN] synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6] synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6] synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6] synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6] synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6] xref: EC:2.4.2.6 xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050145 name: nucleoside monophosphate kinase activity namespace: molecular_function alt_id: GO:0019201 def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732] {comment="EC:2.7.4.4"} synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4] synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4] synonym: "nucleoside monophosphate kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "nucleoside-phosphate kinase activity" EXACT [] synonym: "nucleotide kinase activity" RELATED [] xref: EC:2.7.4.4 xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN xref: Reactome:R-HSA-2162092 "carbovir monophosphate + ATP => carbovir diphosphate + ADP" xref: Reactome:R-HSA-6788798 "AK4 phosphorylates (d)NMPs to (d)NDPs" xref: Reactome:R-HSA-6788810 "AK6 phosphorylates (d)NMPs to (d)NDPs" xref: Reactome:R-HSA-73548 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)" xref: Reactome:R-HSA-73635 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]" xref: Reactome:R-HSA-75125 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)" xref: Reactome:R-HSA-75126 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]" xref: RHEA:24036 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity relationship: part_of GO:0046940 ! nucleoside monophosphate phosphorylation [Term] id: GO:0050146 name: nucleoside phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN] synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] xref: EC:2.7.1.77 xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN xref: Reactome:R-HSA-2162066 "carbovir + IMP => carbovir monophosphate + inosine" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0050147 name: nucleoside ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN] synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5] synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5] xref: EC:2.4.2.5 xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050148 name: nucleotide diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN] synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.4 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0050149 name: o-aminophenol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN] synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4] synonym: "GriF" RELATED [EC:1.10.3.4] synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4] synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] xref: EC:1.10.3.4 xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0050150 name: o-pyrocatechuate decarboxylase activity namespace: molecular_function alt_id: GO:0018790 def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.46, RHEA:21492] synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46] synonym: "2,3-dihydroxybenzoate decarboxylase activity" EXACT [] synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46] xref: EC:4.1.1.46 xref: KEGG_REACTION:R00821 xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN xref: RHEA:21492 xref: UM-BBD_reactionID:r0579 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050151 name: oleate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate." [EC:4.2.1.53, RHEA:21852] synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53] synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53] xref: EC:4.2.1.53 xref: KEGG_REACTION:R02813 xref: MetaCyc:OLEATE-HYDRATASE-RXN xref: RHEA:21852 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050152 name: omega-amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN] synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3] synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3] synonym: "w-amidase activity" EXACT [] xref: EC:3.5.1.3 xref: MetaCyc:OMEGA-AMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050153 name: omega-hydroxydecanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH." [EC:1.1.1.66, RHEA:20880] synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66] synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT [] xref: EC:1.1.1.66 xref: KEGG_REACTION:R03886 xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN xref: RHEA:20880 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050154 name: opheline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+)." [EC:2.7.3.7, RHEA:17553] synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7] xref: EC:2.7.3.7 xref: KEGG_REACTION:R04388 xref: MetaCyc:OPHELINE-KINASE-RXN xref: RHEA:17553 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050155 name: ornithine(lysine) transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN] synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [] synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [] synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "ornithine(lysine) aminotransferase activity" EXACT [] xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN xref: RHEA:23795 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050156 name: ornithine N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)." [EC:2.3.1.127, RHEA:16929] synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127] synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127] xref: EC:2.3.1.127 xref: KEGG_REACTION:R00664 xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN xref: RHEA:16929 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050157 name: ornithine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN] xref: EC:5.1.1.12 xref: MetaCyc:ORNITHINE-RACEMASE-RXN xref: RHEA:11584 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0050158 name: orotate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate." [EC:1.3.1.15, RHEA:14861] synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15] synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15] synonym: "orotate reductase activity" EXACT [EC:1.3.1.15] xref: EC:1.3.1.15 xref: KEGG_REACTION:R01866 xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN xref: RHEA:14861 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050159 name: orsellinate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol." [EC:4.1.1.58, RHEA:16733] synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58] synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58] xref: EC:4.1.1.58 xref: KEGG_REACTION:R02831 xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN xref: RHEA:16733 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050160 name: orsellinate-depside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+)." [EC:3.1.1.40, RHEA:19549] synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40] xref: EC:3.1.1.40 xref: KEGG_REACTION:R00054 xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN xref: RHEA:19549 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050161 name: succinyl-CoA:oxalate CoA-transferase namespace: molecular_function def: "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23588] synonym: "oxalate CoA-transferase activity" EXACT [EC:2.8.3.2] synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2] synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2] xref: EC:2.8.3.2 xref: KEGG_REACTION:R01559 xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN xref: RHEA:23588 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0050162 name: oxalate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2)." [EC:1.2.3.4, RHEA:21881] synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4] synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4] synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4] xref: EC:1.2.3.4 xref: KEGG_REACTION:R00273 xref: MetaCyc:OXALATE-OXIDASE-RXN xref: RHEA:21881 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050163 name: oxaloacetate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, RHEA:16021] synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2] synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2] xref: EC:5.3.2.2 xref: KEGG_REACTION:R00363 xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN xref: RHEA:16021 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0050164 name: oxoglutarate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA." [EC:1.2.1.52, RHEA:21400] synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52] xref: EC:1.2.1.52 xref: KEGG_REACTION:R00265 xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21400 is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity [Term] id: GO:0050165 name: pantetheine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN] synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34] synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34] xref: EC:2.7.1.34 xref: MetaCyc:PANTETHEINE-KINASE-RXN xref: RHEA:22472 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050166 name: pantoate 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH." [EC:1.1.1.106, RHEA:23000] synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] synonym: "panthothenase activity" EXACT [EC:1.1.1.106] synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106] xref: EC:1.1.1.106 xref: KEGG_REACTION:R02471 xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN xref: RHEA:23000 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050167 name: pantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2)." [EC:4.1.1.30, RHEA:15077] synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30] synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30] xref: EC:4.1.1.30 xref: KEGG_REACTION:R02972 xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN xref: RHEA:15077 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050168 name: pentanamidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate." [EC:3.5.1.50, RHEA:10000] synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50] synonym: "valeramidase activity" EXACT [EC:3.5.1.50] xref: EC:3.5.1.50 xref: KEGG_REACTION:R02938 xref: MetaCyc:PENTANAMIDASE-RXN xref: RHEA:10000 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050169 name: peptide-tryptophan 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN, PMID:4403729] synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26] synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26] synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26] synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26] xref: EC:1.13.11.26 xref: MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0050170 name: peptidyl-glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN] synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43] synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43] xref: EC:3.5.1.43 xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050171 name: phenol beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN] synonym: "phenol b-glucosyltransferase activity" EXACT [] synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35] synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35] xref: EC:2.4.1.35 xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050172 name: phenylalanine 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O." [EC:1.13.12.9, RHEA:10712] synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9] synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9] synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9] synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9] xref: EC:1.13.12.9 xref: KEGG_REACTION:R00690 xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN xref: RHEA:10712 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050173 name: phenylalanine adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+)." [EC:2.7.7.54, RHEA:17189] synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT [] synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] xref: EC:2.7.7.54 xref: KEGG_REACTION:R00687 xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN xref: RHEA:17189 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0050174 name: phenylalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53] xref: EC:4.1.1.53 xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN xref: RHEA:19717 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050175 name: phenylalanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN] synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20] synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20] synonym: "PHD" RELATED [EC:1.4.1.20] synonym: "PheDH activity" EXACT [EC:1.4.1.20] xref: EC:1.4.1.20 xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN xref: RHEA:21408 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050176 name: phenylalanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)." [EC:2.3.1.53, RHEA:17801] synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53] synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53] xref: EC:2.3.1.53 xref: KEGG_REACTION:R00693 xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN xref: RHEA:17801 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0050177 name: phenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN] synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43] synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43] xref: EC:4.1.1.43 xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN xref: RHEA:14185 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050178 name: phenylpyruvate tautomerase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN] synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1] synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1] xref: EC:5.3.2.1 xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN xref: RHEA:17097 is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups [Term] id: GO:0050179 name: phenylserine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21712] synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26] synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26] xref: EC:4.1.2.26 xref: KEGG_REACTION:R01766 xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN xref: RHEA:21712 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050180 name: phloretin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23396] synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4] xref: EC:3.7.1.4 xref: KEGG_REACTION:R02901 xref: MetaCyc:PHLORETIN-HYDROLASE-RXN xref: RHEA:23396 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0050181 name: phorbol-diester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21316] synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51] synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51] synonym: "PDEH" RELATED [EC:3.1.1.51] synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51] xref: EC:3.1.1.51 xref: KEGG_REACTION:R04119 xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN xref: RHEA:21316 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050182 name: phosphate butyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20892] synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19] synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19] xref: EC:2.3.1.19 xref: KEGG_REACTION:R01174 xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN xref: RHEA:20892 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050183 name: phosphatidylcholine 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+)." [EC:1.14.18.4, RHEA:46360] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.18.4] synonym: "oleate D12-hydroxylase activity" EXACT [] synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.18.4] synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.18.4] synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.18.4] synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.18.4] xref: EC:1.14.18.4 xref: KEGG_REACTION:R03476 xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN xref: RHEA:46360 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050184 name: phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." [EC:1.3.1.35, RHEA:12564] synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35] synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35] synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35] synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35] xref: EC:1.3.1.35 xref: KEGG_REACTION:R03475 xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN xref: RHEA:12564 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050185 name: phosphatidylinositol deacylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [EC:3.1.1.52, RHEA:18001] synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52] synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52] xref: EC:3.1.1.52 xref: KEGG_REACTION:R03360 xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN xref: RHEA:18001 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050186 name: phosphoadenylylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN] synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2] synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2] synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2] synonym: "phosphoadenylylsulphatase activity" EXACT [] xref: EC:3.6.2.2 xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN xref: RHEA:11232 is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides [Term] id: GO:0050187 name: phosphoamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate." [EC:3.9.1.1, RHEA:12977] synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1] synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1] xref: EC:3.9.1.1 xref: KEGG_REACTION:R01882 xref: MetaCyc:PHOSPHOAMIDASE-RXN xref: RHEA:12977 is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds [Term] id: GO:0050188 name: phosphoenolpyruvate mutase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17013] synonym: "PEP mutase activity" EXACT [EC:5.4.2.9] synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "PEPPM" RELATED [EC:5.4.2.9] synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9] synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9] xref: EC:5.4.2.9 xref: KEGG_REACTION:R00661 xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN xref: RHEA:17013 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0050189 name: phosphoenolpyruvate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:19997] synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60] synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60] xref: EC:3.1.3.60 xref: KEGG_REACTION:R00208 xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN xref: RHEA:19997 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050190 name: phosphoglucokinase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.10, RHEA:13377] synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10] synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10] xref: EC:2.7.1.10 xref: KEGG_REACTION:R00949 xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN xref: RHEA:13377 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050191 name: phosphoglycerate kinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+)." [EC:2.7.2.10, RHEA:23332] synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10] xref: EC:2.7.2.10 xref: KEGG_REACTION:R01517 xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN xref: RHEA:23332 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0050192 name: phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21156] synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20] synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20] synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20] xref: EC:3.1.3.20 xref: KEGG_REACTION:R01748 xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21156 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050193 name: phosphoketolase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN] synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9] synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9] synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9] xref: EC:4.1.2.9 xref: MetaCyc:PHOSPHOKETOLASE-RXN xref: RHEA:10468 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050194 name: phosphonoacetaldehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate." [EC:3.11.1.1, RHEA:18905] synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] synonym: "phosphonatase activity" EXACT [EC:3.11.1.1] synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] xref: EC:3.11.1.1 xref: KEGG_REACTION:R00747 xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN xref: RHEA:18905 is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds [Term] id: GO:0050195 name: phosphoribokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+)." [EC:2.7.1.18, RHEA:21216] synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18] synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18] xref: EC:2.7.1.18 xref: KEGG_REACTION:R01050 xref: MetaCyc:PHOSPHORIBOKINASE-RXN xref: RHEA:21216 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050196 name: [phosphorylase] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN] synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17] synonym: "phosphorylase phosphatase activity" EXACT [] synonym: "PR-enzyme" RELATED [EC:3.1.3.17] synonym: "protein phosphatase C" RELATED [EC:3.1.3.17] synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17] xref: EC:3.1.3.17 xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0050197 name: phytanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21380] synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24] synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24] xref: EC:6.2.1.24 xref: KEGG_REACTION:R03631 xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN xref: Reactome:R-HSA-389622 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate" xref: RHEA:21380 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050198 name: pinosylvin synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12552] synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146] synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146] xref: EC:2.3.1.146 xref: KEGG_REACTION:R02505 xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN xref: RHEA:12552 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050199 name: piperidine N-piperoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+)." [EC:2.3.1.145, RHEA:14561] synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145] synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] xref: EC:2.3.1.145 xref: KEGG_REACTION:R03994 xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN xref: RHEA:14561 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050200 name: plasmalogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN] synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25] synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25] xref: EC:2.3.1.25 xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050201 name: fucokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.52, RHEA:13241] synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52] synonym: "fucose kinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52] synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52] xref: EC:2.7.1.52 xref: KEGG_REACTION:R03161 xref: MetaCyc:FUCOKINASE-RXN xref: Reactome:R-HSA-6787540 "FUK phosphorylates beta-Fuc to Fuc1P" xref: RHEA:13241 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050202 name: octopamine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+)." [EC:4.2.1.87, RHEA:18173] synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87] synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87] synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87] xref: EC:4.2.1.87 xref: KEGG_REACTION:R03358 xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN xref: RHEA:18173 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050203 name: oxalate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." [EC:6.2.1.8, RHEA:18293] synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8] synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8] synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8] xref: EC:6.2.1.8 xref: KEGG_REACTION:R01558 xref: MetaCyc:OXALATE--COA-LIGASE-RXN xref: RHEA:18293 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050204 name: oxalomalate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate." [EC:4.1.3.13, RHEA:22032] synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13] synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13] xref: EC:4.1.3.13 xref: KEGG_REACTION:R00477 xref: MetaCyc:OXALOMALATE-LYASE-RXN xref: RHEA:22032 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0050205 name: oxamate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22984] synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5] synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5] xref: EC:2.1.3.5 xref: KEGG_REACTION:R02937 xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:22984 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050206 name: oximinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [EC:2.6.3.1, RHEA:11624] synonym: "oximase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1] synonym: "transoximase activity" EXACT [EC:2.6.3.1] synonym: "transoximinase activity" EXACT [EC:2.6.3.1] xref: EC:2.6.3.1 xref: KEGG_REACTION:R03796 xref: MetaCyc:OXIMINOTRANSFERASE-RXN xref: RHEA:11624 is_a: GO:0016770 ! oximinotransaminase activity [Term] id: GO:0050207 name: plasmanylethanolamine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN] synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19] synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19] synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19] synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19] synonym: "plasmenylethanolamine desaturase activity" EXACT [] xref: EC:1.14.99.19 xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN xref: RHEA:22956 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050208 name: polysialic-acid O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136] synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136] synonym: "LRAT" RELATED [EC:2.3.1.136] synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136] xref: EC:2.3.1.136 xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050209 name: polyvinyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN] synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30] synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30] synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30] xref: EC:1.1.3.30 xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050210 name: prenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN] synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1] synonym: "prenyl-pyrophosphatase activity" EXACT [] synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1] xref: EC:3.1.7.1 xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN xref: RHEA:21496 is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0050211 name: procollagen galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN] synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] xref: EC:2.4.1.50 xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1981120 "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2." xref: Reactome:R-HSA-1981128 "Galactosylation of collagen propeptide hydroxylysines by PLOD3" is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0050212 name: progesterone 11-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O." [EC:1.14.99.14, RHEA:18205] synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11a-monooxygenase activity" EXACT [] synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14] synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14] xref: EC:1.14.99.14 xref: KEGG_REACTION:R02214 xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN xref: RHEA:18205 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050213 name: progesterone 5-alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN] synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30] synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30] synonym: "progesterone 5a-reductase activity" EXACT [] synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30] xref: EC:1.3.1.30 xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN xref: RHEA:21952 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050214 name: progesterone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate." [EC:1.14.99.4, RHEA:11984] synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4] synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4] xref: EC:1.14.99.4 xref: KEGG_REACTION:R02212 xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN xref: RHEA:11984 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050215 name: propanediol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal." [EC:4.2.1.28, RHEA:14569] synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28] synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28] synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28] synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28] synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28] xref: EC:4.2.1.28 xref: KEGG_REACTION:R02376 xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN xref: RHEA:14569 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050216 name: propanediol-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21584] xref: EC:1.1.1.7 xref: KEGG_REACTION:R04236 xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN xref: RHEA:21584 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050217 name: propioin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal." [EC:4.1.2.35, RHEA:11100] synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35] synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35] xref: EC:4.1.2.35 xref: KEGG_REACTION:R00038 xref: MetaCyc:PROPIOIN-SYNTHASE-RXN xref: RHEA:11100 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050218 name: propionate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN] synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17] synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17] xref: EC:6.2.1.17 xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN xref: RHEA:20373 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050219 name: prostaglandin-A1 delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1." [EC:5.3.3.9, RHEA:10460] synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9] synonym: "prostaglandin-A1 D-isomerase activity" EXACT [] xref: EC:5.3.3.9 xref: KEGG_REACTION:R04565 xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN xref: RHEA:10460 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050220 name: prostaglandin-E synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12893] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3] synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3] synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3] xref: EC:5.3.99.3 xref: KEGG_REACTION:R02265 xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN xref: Reactome:R-HSA-2161660 "PGH2 is isomerised to PGE2 by PTGES" xref: Reactome:R-HSA-265295 "Prostaglandin E synthase isomerizes PGH2 to PGE2" xref: RHEA:12893 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0050221 name: prostaglandin-E2 9-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189] synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189] synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189] synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189] synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189] xref: EC:1.1.1.189 xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN xref: Reactome:R-HSA-2161651 "PGE2 is converted to PGF2a by CBR1" xref: RHEA:24508 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050223 name: protocatechuate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.63, RHEA:22416] synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63] synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63] synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63] xref: EC:4.1.1.63 xref: KEGG_REACTION:R00822 xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN xref: RHEA:22416 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050224 name: prunasin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16489] synonym: "prunasin b-glucosidase activity" EXACT [] synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118] synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118] xref: EC:3.2.1.118 xref: KEGG_REACTION:R02558 xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN xref: RHEA:16489 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050225 name: pseudouridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22448] synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83] synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83] xref: EC:2.7.1.83 xref: KEGG_REACTION:R03315 xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN xref: RHEA:22448 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050226 name: psychosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN] synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13] synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "psychosine sulphotransferase activity" EXACT [] xref: EC:2.8.2.13 xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050227 name: pteridine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN] synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1] xref: EC:1.17.3.1 xref: MetaCyc:PTERIDINE-OXIDASE-RXN is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0050228 name: pterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN] synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11] synonym: "acrasinase activity" EXACT [EC:3.5.4.11] xref: EC:3.5.4.11 xref: MetaCyc:PTERIN-DEAMINASE-RXN xref: RHEA:11904 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050229 name: pterocarpin synthase activity namespace: molecular_function def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN] synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246] synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246] xref: EC:1.1.1.246 xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN xref: RHEA:13533 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050230 name: purine imidazole-ring cyclase activity namespace: molecular_function def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] xref: EC:4.3.2.4 xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0050231 name: putrescine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate." [EC:2.1.3.6, RHEA:21936] synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6] synonym: "PTCase activity" EXACT [EC:2.1.3.6] synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6] synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6] xref: EC:2.1.3.6 xref: KEGG_REACTION:R01399 xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN xref: RHEA:21936 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0050232 name: putrescine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10] xref: EC:1.4.3.10 xref: MetaCyc:PUTRESCINE-OXIDASE-RXN xref: RHEA:18273 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0050233 name: pyranose oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2)." [EC:1.1.3.10, RHEA:10552] synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10] synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10] xref: EC:1.1.3.10 xref: KEGG_REACTION:R00302 xref: MetaCyc:PYRANOSE-OXIDASE-RXN xref: RHEA:10552 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050234 name: pyrazolylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O." [EC:4.2.1.50, RHEA:24512] synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50] synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50] xref: EC:4.2.1.50 xref: KEGG_REACTION:R02378 xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN xref: RHEA:24512 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050235 name: pyridoxal 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH." [EC:1.1.1.107, RHEA:21336] synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107] synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107] xref: EC:1.1.1.107 xref: KEGG_REACTION:R01707 xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN xref: RHEA:21336 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050236 name: pyridoxine:NADP 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16129] synonym: "PL reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine:NADP 4-oxidoreductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65] xref: EC:1.1.1.65 xref: KEGG_REACTION:R01708 xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN xref: RHEA:16129 is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] id: GO:0050237 name: pyridoxine 4-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN] synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12] synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12] xref: EC:1.1.3.12 xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN xref: RHEA:15033 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050238 name: pyridoxine 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN] synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9] synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9] xref: EC:1.1.99.9 xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN xref: RHEA:14497 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050239 name: pyrithiamine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN] synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20] xref: EC:3.5.4.20 xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN xref: RHEA:14537 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050240 name: pyrogallol 1,2-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." [EC:1.13.11.35, RHEA:19673] synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35] synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35] xref: EC:1.13.11.35 xref: KEGG_REACTION:R03246 xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN xref: RHEA:19673 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050241 name: pyrroline-2-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN] synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1] synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1] xref: EC:1.5.1.1 xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050242 name: pyruvate, phosphate dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate." [EC:2.7.9.1, RHEA:10756] synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1] synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1] synonym: "PPDK" RELATED [EC:2.7.9.1] synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1] synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1] xref: EC:2.7.9.1 xref: KEGG_REACTION:R00206 xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN xref: RHEA:10756 is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0050243 name: pyruvate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH." [EC:1.2.1.51, RHEA:17425] synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51] synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51] xref: EC:1.2.1.51 xref: KEGG_REACTION:R00210 xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP%2b-RXN xref: RHEA:17425 is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity [Term] id: GO:0050244 name: pyruvate oxidase (CoA-acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2)." [EC:1.2.3.6, RHEA:21912] synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6] xref: EC:1.2.3.6 xref: KEGG_REACTION:R00211 xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN xref: RHEA:21912 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050245 name: quercitrinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, RHEA:17465] synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66] xref: EC:3.2.1.66 xref: KEGG_REACTION:R02436 xref: MetaCyc:QUERCITRINASE-RXN xref: RHEA:17465 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050246 name: questin monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+)." [EC:1.14.13.43, RHEA:10836] synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43] synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43] xref: EC:1.14.13.43 xref: KEGG_REACTION:R02417 xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN xref: RHEA:10836 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050247 name: raucaffricine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14557] synonym: "raucaffricine b-glucosidase activity" EXACT [] synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125] synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125] xref: EC:3.2.1.125 xref: KEGG_REACTION:R03703 xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN xref: RHEA:14557 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050248 name: Renilla-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "aequorin activity" NARROW [EC:1.13.12.5] synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5] synonym: "luciferase activity" BROAD [EC:1.13.12.5] synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5] synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5] xref: EC:1.13.12.5 xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN xref: RHEA:14765 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0050249 name: Renilla-luciferin sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate." [EC:2.8.2.10, RHEA:20481] synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10] synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10] synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10] synonym: "Renilla-luciferin sulphotransferase activity" EXACT [] xref: EC:2.8.2.10 xref: KEGG_REACTION:R03138 xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN xref: RHEA:20481 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050250 name: retinal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN] synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11] synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11] xref: EC:1.2.3.11 xref: MetaCyc:RETINAL-OXIDASE-RXN xref: RHEA:22520 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0050251 name: retinol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [GOC:pde, RHEA:19141] synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [] synonym: "all-trans-retinol isomerase activity" EXACT [] xref: KEGG_REACTION:R02369 xref: MetaCyc:RETINOL-ISOMERASE-RXN xref: Reactome:R-HSA-2465926 "An atROL isomerase isomerises atROL to 11cROL" xref: RHEA:19141 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0050252 name: retinol O-fatty-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76] synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76] xref: EC:2.3.1.76 xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-2465919 "AWAT2 transfers PALM to 11cROL forming 11cRPALM" xref: Reactome:R-HSA-8848585 "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM" xref: RHEA:11488 is_a: GO:0008374 ! O-acyltransferase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0050253 name: retinyl-palmitate esterase activity namespace: molecular_function def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+." [MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN, RHEA:21508] synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21] synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21] synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21] xref: EC:3.1.1 xref: KEGG_REACTION:R02368 xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN xref: Reactome:R-HSA-2404133 "A REH hydrolses atREs to atROL and FAs" xref: Reactome:R-HSA-8848355 "PNPLA4 hydrolyzes retinyl palmitate" xref: Reactome:R-HSA-975593 "PNLIP:CLPS hydrolyses RPALM to atROL and PALM" xref: Reactome:R-HSA-975594 "PLB1 hydrolyses RPALM to atROL" xref: RHEA:21508 is_a: GO:0052689 ! carboxylic ester hydrolase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0050254 name: rhodopsin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14] synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14] synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14] synonym: "GRK1" RELATED [EC:2.7.11.14] synonym: "GRK7" RELATED [EC:2.7.11.14] synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "opsin kinase activity" EXACT [EC:2.7.11.14] synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] synonym: "RK" RELATED [EC:2.7.11.14] synonym: "STK14" RELATED [EC:2.7.11.14] xref: EC:2.7.11.14 xref: MetaCyc:2.7.11.14-RXN xref: Reactome:R-HSA-2581474 "GRK1,4,7 phosphorylate MII to p-MII" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050255 name: ribitol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.56, RHEA:20053] synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56] synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56] xref: EC:1.1.1.56 xref: KEGG_REACTION:R01895 xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN xref: RHEA:20053 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050256 name: ribitol-5-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN] synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137] synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137] xref: EC:1.1.1.137 xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050257 name: riboflavin phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20409] synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42] synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42] xref: EC:2.7.1.42 xref: KEGG_REACTION:R00550 xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN xref: RHEA:20409 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050258 name: riboflavinase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11408] synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1] xref: EC:3.5.99.1 xref: KEGG_REACTION:R01732 xref: MetaCyc:RIBOFLAVINASE-RXN xref: RHEA:11408 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0050259 name: ribose 1-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH." [EC:1.1.1.115, RHEA:11676] synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115] synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115] synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115] xref: EC:1.1.1.115 xref: KEGG_REACTION:R01079 xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN xref: RHEA:11676 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050260 name: ribose-5-phosphate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.7, RHEA:13777] synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7] synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7] xref: EC:6.3.4.7 xref: KEGG_REACTION:R01053 xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN xref: RHEA:13777 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0050261 name: ribose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: ribofuranose = D-ribulose." [EC:5.3.1.20, RHEA:20796] synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20] synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20] xref: EC:5.3.1.20 xref: KEGG_REACTION:R01081 xref: MetaCyc:RIBOSE-ISOMERASE-RXN xref: RHEA:20796 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0050262 name: ribosylnicotinamide kinase activity namespace: molecular_function alt_id: GO:0000816 def: "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017] synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22] synonym: "nicotinamide riboside kinase activity" EXACT [PMID:15137942] synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22] xref: EC:2.7.1.22 xref: KEGG_REACTION:R02324 xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN xref: Reactome:R-HSA-8869627 "NMRK2 phosphorylates NR to yield NMN" xref: Reactome:R-HSA-8869633 "NMRK1 phosphorylates NR to yield NMN" xref: RHEA:14017 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050263 name: ribosylpyrimidine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN] synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8] synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8] synonym: "RihB" RELATED [EC:3.2.2.8] synonym: "YeiK" RELATED [EC:3.2.2.8] xref: EC:3.2.2.8 xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0050264 name: rifamycin-B oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O." [EC:1.10.3.6, RHEA:11292] synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6] synonym: "rifamycin-B-oxidase activity" EXACT [] synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6] xref: EC:1.10.3.6 xref: KEGG_REACTION:R03736 xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN xref: RHEA:11292 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0050265 name: RNA uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] synonym: "poly(U) polymerase activity" EXACT [GOC:dph, GOC:mah] synonym: "polynucleotide uridylyltransferase activity" EXACT [GOC:dph, GOC:mah] synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52] synonym: "TUT activity" EXACT [EC:2.7.7.52] synonym: "UTP:RNA uridylyltransferase activity" EXACT [] xref: EC:2.7.7.52 xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-8941312 "ZCCHC6, ZCCHC11 are mRNA uridyltransferases" is_a: GO:0070569 ! uridylyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0050266 name: rosmarinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN] synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140] synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140] synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140] xref: EC:2.3.1.140 xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN xref: RHEA:22344 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050267 name: rubber cis-polyprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN] synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20] synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20] synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] xref: EC:2.5.1.20 xref: MetaCyc:2.5.1.20-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0050268 name: coniferyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107] synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194] xref: EC:1.1.1.194 xref: MetaCyc:RXN-2602 xref: RHEA:22444 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050269 name: coniferyl-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241] synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68] xref: EC:1.2.1.68 xref: MetaCyc:RXN-1241 is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0050270 name: S-adenosylhomocysteine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+)." [EC:3.5.4.28, RHEA:20716] synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28] synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28] xref: EC:3.5.4.28 xref: KEGG_REACTION:R00193 xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN xref: RHEA:20716 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050271 name: S-alkylcysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN] synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6] synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6] xref: EC:4.4.1.6 xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN xref: RHEA:22424 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050272 name: S-carboxymethylcysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+)." [EC:4.5.1.5, RHEA:22868] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5] synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5] synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5] xref: EC:4.5.1.5 xref: KEGG_REACTION:R04003 xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN xref: RHEA:22868 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0050273 name: S-succinylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate." [EC:3.1.2.13, RHEA:16713] xref: EC:3.1.2.13 xref: KEGG_REACTION:R00499 xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN xref: RHEA:16713 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0050274 name: salicyl-alcohol beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP." [EC:2.4.1.172, RHEA:11512] synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT [] synonym: "salicyl-alcohol glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172] xref: EC:2.4.1.172 xref: KEGG_REACTION:R03558 xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN xref: RHEA:11512 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050275 name: scopoletin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP." [EC:2.4.1.128, RHEA:20453] synonym: "SGTase activity" EXACT [EC:2.4.1.128] synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] xref: EC:2.4.1.128 xref: KEGG_REACTION:R03594 xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN xref: RHEA:20453 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050276 name: scyllo-inosamine 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.65, RHEA:18605] synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65] synonym: "scyllo-inosamine kinase activity" EXACT [] xref: EC:2.7.1.65 xref: KEGG_REACTION:R03384 xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN xref: RHEA:18605 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050277 name: sedoheptulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23844] synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14] synonym: "heptulokinase activity" EXACT [EC:2.7.1.14] synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14] xref: EC:2.7.1.14 xref: KEGG_REACTION:R01844 xref: MetaCyc:SEDOHEPTULOKINASE-RXN xref: Reactome:R-HSA-8959719 "SHPK phosphorylates Sedo to Sedo7P" xref: RHEA:23844 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050278 name: sedoheptulose-bisphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN] synonym: "SBPase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37] xref: EC:3.1.3.37 xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN xref: RHEA:17461 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050279 name: sepiapterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN] synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24] xref: EC:3.5.4.24 xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN xref: RHEA:14025 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050280 name: sequoyitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.143, RHEA:11300] synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143] xref: EC:1.1.1.143 xref: KEGG_REACTION:R03497 xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN xref: RHEA:11300 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050281 name: serine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN] synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45] synonym: "serine--glyoxylate aminotransferase activity" EXACT [] synonym: "SGAT activity" EXACT [EC:2.6.1.45] xref: EC:2.6.1.45 xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN xref: RHEA:19125 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050282 name: serine 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN] synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7] synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7] synonym: "serine dehydrogenase activity" EXACT [] xref: EC:1.4.1.7 xref: MetaCyc:SERINE-DEHYDROGENASE-RXN xref: RHEA:20884 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050283 name: serine-sulfate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN] synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10] synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10] synonym: "serine-sulphate ammonia-lyase activity" EXACT [] xref: EC:4.3.1.10 xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN xref: RHEA:15605 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0050284 name: sinapate 1-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN] synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120] synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120] xref: EC:2.4.1.120 xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN xref: RHEA:13305 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050285 name: sinapine esterase activity namespace: molecular_function def: "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate." [EC:3.1.1.49, RHEA:10016] synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49] synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49] xref: EC:3.1.1.49 xref: KEGG_REACTION:R02381 xref: MetaCyc:SINAPINE-ESTERASE-RXN xref: RHEA:10016 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050286 name: sorbitol-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24580] synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50] synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50] xref: EC:3.1.3.50 xref: KEGG_REACTION:R02866 xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN xref: RHEA:24580 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050287 name: sorbose 5-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH." [EC:1.1.1.123, RHEA:15001] synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123] synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123] synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123] synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123] synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123] xref: EC:1.1.1.123 xref: KEGG_REACTION:R01694 xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN xref: RHEA:15001 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050288 name: sorbose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14713] synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12] synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12] xref: EC:1.1.99.12 xref: KEGG_REACTION:R01696 xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN xref: RHEA:14713 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050289 name: spermidine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN] synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6] synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6] xref: EC:1.5.99.6 xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN xref: RHEA:14273 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0050290 name: sphingomyelin phosphodiesterase D activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+)." [EC:3.1.4.41, RHEA:20984] synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41] synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41] xref: EC:3.1.4.41 xref: KEGG_REACTION:R02542 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN xref: RHEA:20984 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0050291 name: sphingosine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845] synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24] synonym: "ceramide synthase activity" EXACT [] synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24] synonym: "dihydroceramide synthase activity" EXACT [] synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24] xref: EC:2.3.1.24 xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-428185 "sphinganine + stearyl-CoA => dihydroceramide + CoASH" xref: RHEA:23768 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0050292 name: steroid 9-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O." [EC:1.14.99.24, RHEA:19557] synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9a-monooxygenase activity" EXACT [] synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24] synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24] xref: EC:1.14.99.24 xref: KEGG_REACTION:R04392 xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN xref: RHEA:19557 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050293 name: steroid-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate." [EC:3.1.1.37, RHEA:13721] synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37] xref: EC:3.1.1.37 xref: KEGG_REACTION:R03641 xref: MetaCyc:STEROID-LACTONASE-RXN xref: RHEA:13721 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050294 name: steroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] synonym: "steroid sulphotransferase activity" EXACT [] xref: EC:2.8.2.15 xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176517 "SULTs transfer (SO4)2- group to PREG" xref: Reactome:R-HSA-176521 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP" xref: Reactome:R-HSA-176631 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050295 name: steryl-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11956] synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104] synonym: "steryl-b-glucosidase activity" EXACT [] xref: EC:3.2.1.104 xref: KEGG_REACTION:R01460 xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN xref: RHEA:11956 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050296 name: stipitatonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate." [EC:4.1.1.60, RHEA:13885] synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60] synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60] xref: EC:4.1.1.60 xref: KEGG_REACTION:R03739 xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN xref: RHEA:13885 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050297 name: stizolobate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29] xref: EC:1.13.11.29 xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN xref: RHEA:21220 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050298 name: stizolobinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN] synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30] xref: EC:1.13.11.30 xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN xref: RHEA:18465 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050299 name: streptomycin 3''-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18377] synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87] synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] xref: EC:2.7.1.87 xref: KEGG_REACTION:R02227 xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN xref: RHEA:18377 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0050300 name: aminoglycoside 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22268] synonym: "APH(6) activity" EXACT [EC:2.7.1.72] synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72] synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-kinase activity" NARROW [] synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72] synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] xref: EC:2.7.1.72 xref: KEGG_REACTION:R02225 xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN xref: RHEA:22268 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0050301 name: streptomycin-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10688] synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39] synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] xref: EC:3.1.3.39 xref: KEGG_REACTION:R02228 xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN xref: RHEA:10688 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050302 name: indole-3-acetaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+)." [EC:1.2.3.7, RHEA:16277] synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "AO1" RELATED [EC:1.2.3.7] synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7] synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7] synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7] xref: EC:1.2.3.7 xref: KEGG_REACTION:R02681 xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN xref: RHEA:16277 is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0050303 name: lysine 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN] synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18] synonym: "LysDH activity" EXACT [EC:1.4.1.18] xref: EC:1.4.1.18 xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN xref: MetaCyc:PWY-5314 xref: RHEA:25125 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050304 name: nitrous-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide." [EC:1.7.2.4, MetaCyc:RXN-12130] synonym: "N2O reductase activity" EXACT [EC:1.7.2.4] synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.2.4] synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.2.4] synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.2.4] xref: EC:1.7.2.4 xref: KEGG_REACTION:R02804 xref: MetaCyc:RXN-12130 is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0050305 name: strombine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate." [EC:1.5.1.22, RHEA:14061] synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22] synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22] synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22] xref: EC:1.5.1.22 xref: KEGG_REACTION:R00368 xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN xref: RHEA:14061 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050306 name: sucrose 1F-fructosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN] synonym: "SST activity" EXACT [EC:2.4.1.99] synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99] xref: EC:2.4.1.99 xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN xref: RHEA:23312 is_a: GO:0050738 ! fructosyltransferase activity [Term] id: GO:0050307 name: sucrose-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN] synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.24] synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24] synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] xref: EC:3.1.3.24 xref: KEGG_REACTION:R00805 xref: KEGG_REACTION:R06211 xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN xref: RHEA:19289 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0050308 name: sugar-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN] synonym: "sugar-phosphate phosphatase activity" EXACT [] synonym: "sugar-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.23] xref: EC:3.1.3.23 xref: KEGG_REACTION:R00804 xref: MetaCyc:SUGAR-PHOSPHATASE-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0050309 name: sugar-terminal-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN] synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.58] synonym: "xylitol-5-phosphatase activity" NARROW [EC:3.1.3.58] xref: EC:3.1.3.58 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0050310 name: sulfite dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN] synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulphite dehydrogenase activity" EXACT [] xref: EC:1.8.2.1 xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0050311 name: sulfite reductase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN] synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1] synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1] synonym: "sulphite reductase (ferredoxin) activity" EXACT [] xref: EC:1.8.7.1 xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050312 name: sulfoacetaldehyde lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN] comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). synonym: "sulphoacetaldehyde lyase activity" EXACT [] xref: EC:4.4.1 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050313 name: sulfur dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfur + O2 + H2O = sulfite." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN] synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18] synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] synonym: "sulphur dioxygenase activity" EXACT [] xref: EC:1.13.11.18 xref: MetaCyc:FESGSHTHIO-RXN xref: Reactome:R-HSA-1614605 "Persulfide sulfur is dioxygenated" xref: RHEA:24652 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050314 name: sym-norspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+)." [EC:2.5.1.23, RHEA:23244] synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23] xref: EC:2.5.1.23 xref: KEGG_REACTION:R03271 xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN xref: RHEA:23244 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050315 name: synephrine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:17516] synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88] xref: EC:4.2.1.88 xref: KEGG_REACTION:R03359 xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN xref: RHEA:17516 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050316 name: T2-induced deoxynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN] synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12] xref: EC:2.7.4.12 xref: MetaCyc:GMKALT-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0050317 name: tagatose kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.101, RHEA:15513] synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101] synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101] synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101] xref: EC:2.7.1.101 xref: KEGG_REACTION:R02927 xref: MetaCyc:TAGATOSE-KINASE-RXN xref: RHEA:15513 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050318 name: tannase activity namespace: molecular_function def: "Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+)." [EC:3.1.1.20, RHEA:16365] synonym: "tannase S" RELATED [EC:3.1.1.20] synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20] synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20] xref: EC:3.1.1.20 xref: KEGG_REACTION:R00053 xref: MetaCyc:TANNASE-RXN xref: RHEA:16365 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050319 name: tartrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2)." [EC:4.1.1.73, RHEA:13317] synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73] synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73] xref: EC:4.1.1.73 xref: KEGG_REACTION:R01751 xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN xref: RHEA:13317 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050320 name: tartrate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate." [EC:5.1.2.5, RHEA:22212] synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5] xref: EC:5.1.2.5 xref: KEGG_REACTION:R02546 xref: MetaCyc:TARTRATE-EPIMERASE-RXN xref: RHEA:22212 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0050321 name: tau-protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] synonym: "[Tau protein] kinase activity" EXACT [] synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26] synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26] synonym: "cdk5/p20" RELATED [EC:2.7.11.26] synonym: "CDK5/p23" RELATED [EC:2.7.11.26] synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26] synonym: "GSK" RELATED [EC:2.7.11.26] synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26] synonym: "STK31" RELATED [EC:2.7.11.26] synonym: "tau kinase activity" EXACT [EC:2.7.11.26] synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26] synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26] synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26] synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26] synonym: "TPK" RELATED [EC:2.7.11.26] synonym: "TPK I" RELATED [EC:2.7.11.26] synonym: "TPK II" RELATED [EC:2.7.11.26] synonym: "TTK" RELATED [EC:2.7.11.26] xref: EC:2.7.11.26 xref: MetaCyc:TAU-PROTEIN-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050322 name: taurine-2-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:RXN-2301] synonym: "taurine aminotransferase activity" EXACT [] synonym: "taurine transaminase activity" EXACT [] synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55] synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] xref: EC:2.6.1.55 xref: MetaCyc:RXN-2301 xref: RHEA:16353 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0050323 name: taurine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde." [EC:1.4.99.2, RHEA:18709] synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] xref: EC:1.4.99.2 xref: KEGG_REACTION:R07167 xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN xref: RHEA:18709 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0050324 name: taurocyamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.4, RHEA:22516] synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] xref: EC:2.7.3.4 xref: KEGG_REACTION:R03785 xref: MetaCyc:TAUROCYAMINE-KINASE-RXN xref: RHEA:22516 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0050325 name: tauropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12580] synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] xref: EC:1.5.1.23 xref: KEGG_REACTION:R01683 xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN xref: RHEA:12580 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050326 name: taxifolin 8-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN] synonym: "taxifolin hydroxylase activity" EXACT [] synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19] xref: EC:1.14.13.19 xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050328 name: tetrahydroberberine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN] synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8] synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8] synonym: "THB oxidase activity" EXACT [EC:1.3.3.8] xref: EC:1.3.3.8 xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN xref: RHEA:13489 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050329 name: tetrahydroxypteridine cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18097] synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3] xref: EC:5.5.1.3 xref: KEGG_REACTION:R04154 xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN xref: RHEA:18097 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0050330 name: theanine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18013] synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65] synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] xref: EC:3.5.1.65 xref: KEGG_REACTION:R02930 xref: MetaCyc:THEANINE-HYDROLASE-RXN xref: RHEA:18013 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050331 name: thiamine-diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN] synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15] synonym: "TDP kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin diphosphate kinase activity" EXACT [] synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15] synonym: "thiamin-diphosphate kinase activity" EXACT [] synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15] xref: EC:2.7.4.15 xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN xref: Reactome:R-HSA-997381 "TDPK phosphorylates ThDP to ThTP" xref: RHEA:11240 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0050332 name: thiamine pyridinylase activity namespace: molecular_function def: "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17697] synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2] synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamin pyridinylase activity" EXACT [] synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] synonym: "thiaminase I activity" NARROW [EC:2.5.1.2] synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2] synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] xref: EC:2.5.1.2 xref: KEGG_REACTION:R02863 xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN xref: RHEA:17697 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050333 name: thiamin-triphosphatase activity namespace: molecular_function alt_id: GO:0048253 def: "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate." [EC:3.6.1.28, RHEA:11744] synonym: "thiamine-triphosphatase activity" EXACT [] synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28] synonym: "ThTPase activity" EXACT [EC:3.6.1.28] xref: EC:3.6.1.28 xref: KEGG_REACTION:R00618 xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-965067 "THTPA:Mg2+ hydrolyzes ThTP to TDP" xref: RHEA:11744 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0050334 name: thiaminase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)." [EC:3.5.99.2, RHEA:17509] synonym: "thiaminase II activity" NARROW [EC:3.5.99.2] xref: EC:3.5.99.2 xref: KEGG_REACTION:R02133 xref: MetaCyc:THIAMINASE-RXN xref: RHEA:17509 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0050335 name: thiocyanate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, RHEA:10004] synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1] synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1] xref: EC:5.99.1.1 xref: KEGG_REACTION:R04010 xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN xref: RHEA:10004 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0050336 name: thioethanolamine S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23280] synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11] synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11] xref: EC:2.3.1.11 xref: KEGG_REACTION:R03668 xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN xref: RHEA:23280 is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0050337 name: thiosulfate-thiol sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN] synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3] synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3] synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT [] xref: EC:2.8.1.3 xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN xref: Reactome:R-HSA-1655879 "Thiosulfate can transfer its sulfur atom to glutathione" xref: RHEA:14505 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0050338 name: thiosulfate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN] synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2] synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2] synonym: "thiosulphate dehydrogenase activity" EXACT [] xref: EC:1.8.2.2 xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0050339 name: thymidine-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN] synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39] synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39] synonym: "dTTPase activity" EXACT [EC:3.6.1.39] synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39] xref: EC:3.6.1.39 xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN xref: RHEA:19013 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0050340 name: thymidylate 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN] synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "dTMPase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5' phosphatase activity" EXACT [] synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35] synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35] xref: EC:3.1.3.35 xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN xref: RHEA:11080 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050341 name: thymine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN] synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6] synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6] xref: EC:1.14.11.6 xref: MetaCyc:THYMINE-DIOXYGENASE-RXN xref: RHEA:10316 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0050342 name: tocopherol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN] synonym: "gamma-tocopherol methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95] xref: EC:2.1.1.95 xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN xref: RHEA:24012 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0050343 name: trans-2-enoyl-CoA reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN] synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44] xref: EC:1.3.1.44 xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050344 name: trans-cinnamate 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+)." [EC:1.14.13.14, RHEA:10956] synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14] synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT [] xref: EC:1.14.13.14 xref: KEGG_REACTION:R02254 xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN xref: RHEA:10956 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050345 name: trans-epoxysuccinate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20740] synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4] synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4] synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4] xref: EC:3.3.2.4 xref: KEGG_REACTION:R02547 xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN xref: RHEA:20740 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0050346 name: trans-L-3-hydroxyproline dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+)." [EC:4.2.1.77, RHEA:10320] synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77] synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77] xref: EC:4.2.1.77 xref: KEGG_REACTION:R04374 xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN xref: RHEA:10320 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050347 name: trans-octaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate." [RHEA:11324] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11] synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] synonym: "SPP synthase activity" EXACT [EC:2.5.1.11] synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11] synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11] xref: EC:2.5.1.84 xref: EC:2.5.1.85 xref: KEGG_REACTION:R07267 xref: RHEA:11324 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050348 name: trehalose O-mycolyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23472] synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122] synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122] xref: EC:2.3.1.122 xref: KEGG_REACTION:R07248 xref: MetaCyc:RXN1G-874 xref: RHEA:23472 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050349 name: triacetate-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + triacetate lactone = triacetate." [EC:3.1.1.38, RHEA:22260] synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38] synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38] xref: EC:3.1.1.38 xref: KEGG_REACTION:R03702 xref: MetaCyc:TRIACETATE-LACTONASE-RXN xref: RHEA:22260 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050350 name: trihydroxystilbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95] synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95] synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] xref: EC:2.3.1.95 xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN xref: RHEA:11936 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050351 name: trimetaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate." [EC:3.6.1.2, RHEA:11088] synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2] synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2] xref: EC:3.6.1.2 xref: KEGG_REACTION:R02504 xref: MetaCyc:TRIMETAPHOSPHATASE-RXN xref: RHEA:11088 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0050352 name: trimethylamine-oxide aldolase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20217] synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32] synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] xref: EC:4.1.2.32 xref: KEGG_REACTION:R02512 xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN xref: RHEA:20217 xref: UM-BBD_reactionID:r1409 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050353 name: trimethyllysine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14181] synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8] synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "TMLD activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] xref: EC:1.14.11.8 xref: KEGG_REACTION:R03451 xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN xref: Reactome:R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA" xref: RHEA:14181 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0050354 name: triokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.28, RHEA:13941] synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28] synonym: "D-triokinase activity" EXACT [EC:2.7.1.28] synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28] synonym: "triose kinase activity" EXACT [EC:2.7.1.28] xref: EC:2.7.1.28 xref: KEGG_REACTION:R01059 xref: MetaCyc:TRIOKINASE-RXN xref: Reactome:R-HSA-70349 "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate" xref: RHEA:13941 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050355 name: triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14157] synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25] synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25] synonym: "tripolyphosphatase activity" EXACT [PMID:24004165] xref: EC:3.6.1.25 xref: KEGG_REACTION:R00138 xref: MetaCyc:TRIPHOSPHATASE-RXN xref: RHEA:14157 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050356 name: tropine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone." [EC:1.1.1.206, RHEA:18357] synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206] xref: EC:1.1.1.206 xref: KEGG_REACTION:R02832 xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN xref: RHEA:18357 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050357 name: tropinesterase activity namespace: molecular_function def: "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23304] synonym: "atropinase activity" EXACT [EC:3.1.1.10] synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10] synonym: "atropine esterase activity" EXACT [EC:3.1.1.10] synonym: "atropinesterase activity" EXACT [EC:3.1.1.10] synonym: "tropine esterase activity" EXACT [EC:3.1.1.10] xref: EC:3.1.1.10 xref: KEGG_REACTION:R03563 xref: MetaCyc:TROPINESTERASE-RXN xref: RHEA:23304 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050358 name: tropinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone." [EC:1.1.1.236, RHEA:24244] synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236] synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236] synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236] xref: EC:1.1.1.236 xref: KEGG_REACTION:R06734 xref: MetaCyc:TROPINONE-REDUCTASE-RXN xref: RHEA:24244 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050359 name: tropomyosin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN] synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28] synonym: "STK" RELATED [EC:2.7.11.28] synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28] xref: EC:2.7.11.28 xref: MetaCyc:TROPOMYOSIN-KINASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050360 name: tryptophan 2'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN] synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3] synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3] synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3] synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3] synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3] synonym: "TSO activity" RELATED [EC:1.13.99.3] synonym: "TSO I" RELATED [EC:1.13.99.3] synonym: "TSO II" RELATED [EC:1.13.99.3] xref: EC:1.13.99.3 xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN xref: RHEA:22620 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0050361 name: tryptophan 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16165] synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3] xref: EC:1.13.12.3 xref: KEGG_REACTION:R00679 xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN xref: RHEA:16165 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050362 name: L-tryptophan:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN] synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27] synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27] synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27] synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27] synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27] synonym: "tryptophan aminotransferase activity" EXACT [] synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27] xref: EC:2.6.1.27 xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN xref: RHEA:14093 is_a: GO:0070529 ! L-tryptophan aminotransferase activity [Term] id: GO:0050363 name: tryptophan dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN] synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19] synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] synonym: "TDH" RELATED [EC:1.4.1.19] synonym: "TrpDH activity" EXACT [EC:1.4.1.19] xref: EC:1.4.1.19 xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050364 name: tryptophan dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN] synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34] synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34] synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34] xref: EC:2.5.1.34 xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN xref: RHEA:14173 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050365 name: tryptophanamidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+)." [EC:3.5.1.57, RHEA:11012] synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57] synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57] synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57] xref: EC:3.5.1.57 xref: KEGG_REACTION:R00682 xref: MetaCyc:TRYPTOPHANAMIDASE-RXN xref: RHEA:11012 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050366 name: tyramine N-feruloyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN] synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110] synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110] synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110] synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] xref: EC:2.3.1.110 xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN xref: RHEA:19685 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050367 name: tyrosine-arginine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+)." [EC:6.3.2.24, RHEA:15345] synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24] synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24] synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24] synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24] xref: EC:6.3.2.24 xref: KEGG_REACTION:R00735 xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN xref: RHEA:15345 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050368 name: tyrosine 2,3-aminomutase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, RHEA:15781] synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6] synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6] xref: EC:5.4.3.6 xref: KEGG_REACTION:R00739 xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN xref: RHEA:15781 is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups [Term] id: GO:0050369 name: [tyrosine 3-monooxygenase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN] synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6] synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6] synonym: "STK4" RELATED [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6] synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] xref: EC:2.7.11.6 xref: MetaCyc:2.7.11.6-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050370 name: tyrosine N-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN] synonym: "CYP79A1 activity" NARROW [] synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [] synonym: "tyrosine N-hydroxylase activity" EXACT [] xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050371 name: tyrosine phenol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate." [EC:4.1.99.2, RHEA:21704] synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2] synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2] xref: EC:4.1.99.2 xref: KEGG_REACTION:R00728 xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN xref: RHEA:21704 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0050372 name: ubiquitin-calmodulin ligase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN] synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21] synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21] synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21] synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21] xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN is_a: GO:0004842 ! ubiquitin-protein transferase activity [Term] id: GO:0050373 name: UDP-arabinose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose." [EC:5.1.3.5, RHEA:11320] synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDP-D-xylose-4-epimerase activity" EXACT [] synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5] xref: EC:5.1.3.5 xref: KEGG_REACTION:R01473 xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN xref: RHEA:11320 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050374 name: UDP-galacturonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19725] synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67] synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67] synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67] synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67] xref: EC:4.1.1.67 xref: KEGG_REACTION:R02636 xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN xref: RHEA:19725 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050376 name: UDP-glucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN] synonym: "UDP-glucosamine epimerase activity" EXACT [] synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16] xref: EC:5.1.3.16 xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN xref: RHEA:23492 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050377 name: UDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21500] synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76] synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76] synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76] synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] xref: EC:4.2.1.76 xref: KEGG_REACTION:R00293 xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN xref: RHEA:21500 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050378 name: UDP-glucuronate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11404] synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6] synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6] synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6] xref: EC:5.1.3.6 xref: KEGG_REACTION:R01385 xref: MetaCyc:PWY-4861 xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN xref: RHEA:11404 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050379 name: UDP-glucuronate 5'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, RHEA:14677] synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronate 5' epimerase activity" EXACT [] synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12] synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] xref: EC:5.1.3.12 xref: KEGG_REACTION:R01387 xref: MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN xref: Reactome:R-HSA-2024100 "GLCE epimerises GlcA to IdoA" xref: Reactome:R-HSA-2076371 "GLCE epimerises more GlcA to IdoA as sulfate content rises" xref: RHEA:14677 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050380 name: undecaprenyl-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-undecaprenyl diphosphate + H(2)O = all-trans-undecaprenyl phosphate + H(+) + phosphate." [EC:3.6.1.27, RHEA:17069] synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27] xref: EC:3.6.1.27 xref: KEGG_REACTION:R05627 xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN xref: RHEA:17069 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0050382 name: uracil-5-carboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil." [EC:4.1.1.66, RHEA:17685] synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66] synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66] xref: EC:4.1.1.66 xref: KEGG_REACTION:R00973 xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN xref: RHEA:17685 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050383 name: uracil dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN] xref: EC:1.17.99.4 xref: MetaCyc:URACIL-DEHYDROGENASE-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0050384 name: urate-ribonucleotide phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate." [EC:2.4.2.16, RHEA:13909] synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16] synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16] xref: EC:2.4.2.16 xref: KEGG_REACTION:R02646 xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN xref: RHEA:13909 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0050385 name: ureidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, RHEA:11304] comment: Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3] synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3] synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3] synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3] synonym: "ureidoglycolate hydrolase activity" RELATED [PMID:24107613] xref: EC:4.3.2.3 xref: KEGG_REACTION:R00776 xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN xref: RHEA:11304 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0050386 name: ureidosuccinase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+)." [EC:3.5.1.7, RHEA:14365] synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7] xref: EC:3.5.1.7 xref: KEGG_REACTION:R00484 xref: MetaCyc:UREIDOSUCCINASE-RXN xref: RHEA:14365 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050387 name: urethanase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+)." [EC:3.5.1.75, RHEA:21372] synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75] synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75] xref: EC:3.5.1.75 xref: KEGG_REACTION:R02359 xref: MetaCyc:URETHANASE-RXN xref: RHEA:21372 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050388 name: uronate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH." [EC:1.1.1.203, RHEA:22404] synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203] synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203] xref: EC:1.1.1.203 xref: KEGG_REACTION:R01981 xref: MetaCyc:URONATE-DEHYDROGENASE-RXN xref: RHEA:22404 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050389 name: uronolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN] synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19] synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19] xref: EC:3.1.1.19 xref: MetaCyc:URONOLACTONASE-RXN xref: RHEA:13337 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050390 name: valine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2)." [EC:4.1.1.14, RHEA:18989] synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14] synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14] xref: EC:4.1.1.14 xref: KEGG_REACTION:R01437 xref: MetaCyc:VALINE-DECARBOXYLASE-RXN xref: RHEA:18989 xref: UM-BBD_reactionID:r1052 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050391 name: valine dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN] synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8] synonym: "valine dehydrogenase (NADP+) activity" EXACT [] synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8] xref: EC:1.4.1.8 xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN xref: RHEA:11156 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0050392 name: vicianin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14041] synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119] synonym: "vicianin b-glucosidase activity" EXACT [] synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119] xref: EC:3.2.1.119 xref: KEGG_REACTION:R03642 xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN xref: RHEA:14041 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050393 name: vinylacetyl-CoA delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: vinylacetyl-CoA = crotonoyl-CoA." [EC:5.3.3.3, RHEA:10572] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3] synonym: "vinylacetyl-CoA D-isomerase activity" EXACT [] synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3] xref: EC:5.3.3.3 xref: KEGG_REACTION:R03031 xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN xref: RHEA:10572 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0050394 name: viomycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN] synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103] synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103] xref: EC:2.7.1.103 xref: MetaCyc:VIOMYCIN-KINASE-RXN xref: RHEA:20509 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050395 name: vitexin beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21956] synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105] synonym: "vitexin b-glucosyltransferase activity" EXACT [] xref: EC:2.4.1.105 xref: KEGG_REACTION:R03565 xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN xref: RHEA:21956 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050396 name: vomifoliol 4'-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH." [EC:1.1.1.221, RHEA:22804] synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221] xref: EC:1.1.1.221 xref: KEGG_REACTION:R04412 xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN xref: RHEA:22804 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050397 name: Watasenia-luciferin 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN] synonym: "luciferase activity" BROAD [EC:1.13.12.8] synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8] synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8] xref: EC:1.13.12.8 xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN xref: RHEA:18057 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is_a: GO:0045289 ! luciferin monooxygenase activity [Term] id: GO:0050398 name: wax-ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN] synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50] synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50] synonym: "WEH" RELATED [EC:3.1.1.50] xref: EC:3.1.1.50 xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050399 name: xanthommatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13417] synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41] xref: EC:1.3.1.41 xref: KEGG_REACTION:R03787 xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN xref: RHEA:13417 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050400 name: xylitol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20209] synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122] synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122] xref: EC:2.7.1.122 xref: KEGG_REACTION:R02136 xref: MetaCyc:XYLITOL-KINASE-RXN xref: RHEA:20209 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050401 name: xylonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.82, RHEA:19157] synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82] synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82] xref: EC:4.2.1.82 xref: KEGG_REACTION:R02429 xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN xref: RHEA:19157 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050402 name: xylono-1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN] synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68] synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68] synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68] xref: EC:3.1.1.68 xref: MetaCyc:XYLONO-14-LACTONASE-RXN xref: RHEA:18341 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050403 name: trans-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP." [EC:2.4.1.203, RHEA:23224] synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] xref: EC:2.4.1.203 xref: KEGG_REACTION:R02118 xref: MetaCyc:RXN-4723 xref: RHEA:23224 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050404 name: zeatin O-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP." [EC:2.4.2.40, RHEA:14721] comment: Note that this function was formerly EC:2.4.1.204. synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40] synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT [] synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40] xref: EC:2.4.2.40 xref: KEGG_REACTION:R02119 xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN xref: RHEA:14721 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0050405 name: [acetyl-CoA carboxylase] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN] synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27] synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27] synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27] synonym: "ACK2" RELATED [EC:2.7.11.27] synonym: "ACK3" RELATED [EC:2.7.11.27] synonym: "AMPK" RELATED [EC:2.7.11.27] synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27] synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] synonym: "STK5" RELATED [EC:2.7.11.27] xref: EC:2.7.11.27 xref: MetaCyc:2.7.11.27-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0050406 name: [acetyl-CoA carboxylase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN] synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44] xref: EC:3.1.3.44 xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0050407 name: [glycogen-synthase-D] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN] synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42] synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] xref: EC:3.1.3.42 xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0050408 name: [pyruvate kinase]-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN] synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49] synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49] xref: EC:3.1.3.49 xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0050409 name: indolylacetylinositol arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP." [EC:2.4.2.34, RHEA:19505] synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] xref: EC:2.4.2.34 xref: KEGG_REACTION:R04335 xref: MetaCyc:2.4.2.34-RXN xref: RHEA:19505 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0052636 ! arabinosyltransferase activity [Term] id: GO:0050410 name: 3-oxolaurate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2)." [EC:4.1.1.56, RHEA:13385] synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56] synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56] synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56] xref: EC:4.1.1.56 xref: KEGG_REACTION:R03747 xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN xref: RHEA:13385 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050411 name: agaritine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] synonym: "agaritine g-glutamyltransferase activity" EXACT [] xref: EC:2.3.2.9 xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0050412 name: cinnamate beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13437] synonym: "cinnamate b-D-glucosyltransferase activity" EXACT [] synonym: "cinnamate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] xref: EC:2.4.1.177 xref: KEGG_REACTION:R02256 xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN xref: RHEA:13437 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050413 name: D-alanine 2-hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10064] synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] synonym: "D-alanine hydroxymethyltransferase activity" EXACT [] xref: EC:2.1.2.7 xref: KEGG_REACTION:R01225 xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN xref: RHEA:10064 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0050414 name: formimidoylaspartate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN] synonym: "formiminoaspartate deiminase activity" EXACT [] synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5] xref: EC:3.5.3.5 xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN xref: RHEA:13661 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050415 name: formimidoylglutamase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22492] synonym: "formiminoglutamase activity" EXACT [] synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8] synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] xref: EC:3.5.3.8 xref: KEGG_REACTION:R02285 xref: MetaCyc:FORMIMINOGLUTAMASE-RXN xref: RHEA:22492 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050416 name: formimidoylglutamate deiminase activity namespace: molecular_function def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN] synonym: "formiminoglutamate deiminase activity" EXACT [] synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13] synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13] xref: EC:3.5.3.13 xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN xref: RHEA:22832 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0050417 name: glutamin-(asparagin-)ase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN] synonym: "glutaminase-(asparagin-)ase activity" EXACT [] synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38] synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38] synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38] synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38] xref: EC:3.5.1.38 xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050418 name: hydroxylamine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN] synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1] synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1] xref: EC:1.7.99.1 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN xref: RHEA:22052 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0050419 name: hydroxymandelonitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN] synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11] synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11] synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11] synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11] xref: EC:4.1.2.11 xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN xref: RHEA:15977 is_a: GO:0047606 ! hydroxynitrilase activity [Term] id: GO:0050420 name: maltose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN] synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139] xref: EC:2.4.1.139 xref: MetaCyc:MALTOSE-SYNTHASE-RXN xref: RHEA:22320 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050421 name: nitrite reductase (NO-forming) activity namespace: molecular_function alt_id: GO:0016666 def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN] comment: Note that EC:1.7.99.3 was merged into this term. synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1] synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1] synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1] synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1] synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1] synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1] synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1] synonym: "NO-forming nitrite reductase (cytochrome) activity" EXACT [] synonym: "NO-forming nitrite reductase activity" EXACT [] synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] xref: EC:1.7.2.1 xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor is_a: GO:0098809 ! nitrite reductase activity [Term] id: GO:0050422 name: strictosidine beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12917] synonym: "strictosidine b-glucosidase activity" EXACT [] synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105] xref: EC:3.2.1.105 xref: KEGG_REACTION:R03820 xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN xref: RHEA:12917 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0050423 name: thiamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN] synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamin oxidase activity" EXACT [] synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23] synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] xref: EC:1.1.3.23 xref: MetaCyc:THIAMIN-OXIDASE-RXN xref: RHEA:21280 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050424 name: obsolete alanine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "alanine carboxypeptidase activity" EXACT [] synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6] xref: EC:3.4.17.6 xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0050425 name: obsolete carboxypeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase B activity" EXACT [] synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2] synonym: "protaminase activity" RELATED [EC:3.4.17.2] synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] xref: EC:3.4.17.2 xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0050426 name: obsolete peptidyl-glycinamidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2] synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl-glycinamidase activity" EXACT [] xref: EC:3.4.19.2 xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0050427 name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732] synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT [] synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT [] synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT [] synonym: "PAPS metabolic process" EXACT [] synonym: "PAPS metabolism" EXACT [] synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT [] synonym: "phosphoadenosine phosphosulfate metabolism" EXACT [] xref: MetaCyc:PWY-5340 is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0050428 name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732] synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT [] synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT [] synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT [] synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT [] synonym: "PAPS biosynthesis" EXACT [] synonym: "PAPS biosynthetic process" EXACT [] synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT [] synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process [Term] id: GO:0050429 name: calcium-dependent phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [EC:3.1.4.3] is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0050431 name: transforming growth factor beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732] synonym: "TGF-beta binding" EXACT [] synonym: "TGFbeta binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0050432 name: catecholamine secretion namespace: biological_process def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0050433 name: regulation of catecholamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050432 ! catecholamine secretion relationship: regulates GO:0050432 ! catecholamine secretion [Term] id: GO:0050434 name: positive regulation of viral transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai] synonym: "activation of viral transcription" NARROW [] synonym: "stimulation of viral transcription" NARROW [] synonym: "up regulation of viral transcription" EXACT [] synonym: "up-regulation of viral transcription" EXACT [] synonym: "upregulation of viral transcription" EXACT [] is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0048524 ! positive regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019083 ! viral transcription relationship: positively_regulates GO:0019083 ! viral transcription [Term] id: GO:0050435 name: amyloid-beta metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai] synonym: "amyloid-beta metabolism" EXACT [] synonym: "beta-amyloid metabolic process" EXACT [] synonym: "beta-amyloid metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0050436 name: microfibril binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material." [GOC:ai] comment: See also the cellular component term 'microfibril ; GO:0001527'. is_a: GO:0005488 ! binding [Term] id: GO:0050437 name: (-)-endo-fenchol synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20565] synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10] xref: EC:4.2.3.10 xref: KEGG_REACTION:R02004 xref: MetaCyc:4.2.3.10-RXN xref: RHEA:20565 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050438 name: 2-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+)." [EC:2.3.3.6, RHEA:23040] synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6] synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6] synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6] synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6] synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6] xref: EC:2.3.3.6 xref: KEGG_REACTION:R00998 xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN xref: RHEA:23040 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050439 name: 2-hydroxy-3-oxoadipate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2)." [EC:2.2.1.5, RHEA:14341] synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5] synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5] synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5] synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5] synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5] xref: EC:2.2.1.5 xref: KEGG_REACTION:R00474 xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN xref: RHEA:14341 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0050440 name: 2-methylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [EC:2.3.3.5, RHEA:23780] synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5] synonym: "MCS activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5] synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5] synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5] xref: EC:2.3.3.5 xref: KEGG_REACTION:R00931 xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN xref: RHEA:23780 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050441 name: 3-ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." [EC:2.3.3.7, RHEA:10500] synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7] synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7] synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7] xref: EC:2.3.3.7 xref: KEGG_REACTION:R01180 xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN xref: RHEA:10500 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050442 name: 3-propylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)." [EC:2.3.3.12, RHEA:14457] synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12] synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12] synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12] synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12] xref: EC:2.3.3.12 xref: KEGG_REACTION:R03040 xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN xref: RHEA:14457 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050444 name: aquacobalamin reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5] synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5] synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] xref: EC:1.16.1.5 xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN xref: RHEA:20752 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0050445 name: asparagusate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH." [EC:1.8.1.11, RHEA:14881] synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "asparagusate reductase (NADH) activity" EXACT [] synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11] synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11] synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] xref: EC:1.8.1.11 xref: KEGG_REACTION:R03761 xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN xref: RHEA:14881 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050446 name: azobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN] synonym: "azo reductase activity" BROAD [EC:1.7.1.6] synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6] synonym: "azoreductase activity" BROAD [EC:1.7.1.6] synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6] synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6] synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6] synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] synonym: "NC-reductase activity" NARROW [EC:1.7.1.6] synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6] synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6] synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6] synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6] synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6] synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6] synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6] xref: EC:1.7.1.6 xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN xref: RHEA:16269 xref: UM-BBD_reactionID:r0808 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050447 name: zeatin 9-aminocarboxyethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+)." [EC:2.5.1.50, RHEA:17333] synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT [] synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50] synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50] synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50] synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] xref: EC:2.5.1.50 xref: KEGG_REACTION:R03133 xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN xref: RHEA:17333 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050448 name: beta-cyclopiazonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [EC:1.21.99.1, RHEA:14526] synonym: "b-cyclopiazonate dehydrogenase activity" EXACT [] synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1] xref: EC:1.21.99.1 xref: KEGG_REACTION:R04080 xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN xref: RHEA:14526 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0050449 name: casbene synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14901] synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8] xref: EC:4.2.3.8 xref: KEGG_REACTION:R02064 xref: MetaCyc:CASBENE-SYNTHASE-RXN xref: RHEA:14901 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050450 name: citrate (Re)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN] synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3] synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3] synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3] xref: EC:2.3.3.3 xref: MetaCyc:CITRATE-RE-SYNTHASE-RXN is_a: GO:0036440 ! citrate synthase activity [Term] id: GO:0050451 name: CoA-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN] synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14] synonym: "CoA-disulfide reductase (NADH) activity" EXACT [] synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14] synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14] synonym: "CoA-disulphide reductase activity" EXACT [] synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "CoADR activity" EXACT [EC:1.8.1.14] synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14] synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] xref: EC:1.8.1.14 xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050452 name: CoA-glutathione reductase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN] synonym: "CoA-glutathione reductase (NADPH) activity" EXACT [] synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10] synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10] synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] xref: EC:1.8.1.10 xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN xref: RHEA:14617 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050453 name: cob(II)alamin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH." [EC:1.16.1.4, RHEA:17481] synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "B12r reductase activity" EXACT [EC:1.16.1.4] synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4] synonym: "vitamin B12 reductase activity" EXACT [] synonym: "vitamin B12 reduction" RELATED [] synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4] xref: EC:1.16.1.4 xref: KEGG_REACTION:R00099 xref: MetaCyc:COBIIALAMIN-REDUCTASE-RXN xref: Reactome:R-HSA-3149560 "Unknown reductase reduces cob(II)alamin to cob(I)alamin" xref: RHEA:17481 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0050454 name: coenzyme F420 hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420." [EC:1.12.98.1, RHEA:23760] synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1] synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1] xref: EC:1.12.98.1 xref: KEGG_REACTION:R03025 xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN xref: RHEA:23760 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0050455 name: columbamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O." [EC:1.21.3.2, RHEA:23564] synonym: "berberine synthase activity" EXACT [EC:1.21.3.2] synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2] xref: EC:1.21.3.2 xref: KEGG_REACTION:R00044 xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN xref: RHEA:23564 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0050456 name: cystine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH." [EC:1.8.1.6, RHEA:20597] synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6] synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6] synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6] synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6] synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6] xref: EC:1.8.1.6 xref: KEGG_REACTION:R00892 xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN xref: RHEA:20597 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050457 name: decylcitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)." [EC:2.3.3.2, RHEA:16605] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2] synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2] synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2] synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2] xref: EC:2.3.3.2 xref: KEGG_REACTION:R03735 xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN xref: RHEA:16605 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050458 name: decylhomocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)." [EC:2.3.3.4, RHEA:10364] synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4] synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4] synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4] xref: EC:2.3.3.4 xref: KEGG_REACTION:R03859 xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN xref: RHEA:10364 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050459 name: ethanolamine-phosphate phospho-lyase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate." [EC:4.2.3.2, RHEA:17889] synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2] synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2] synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2] synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2] xref: EC:4.2.3.2 xref: KEGG_REACTION:R00748 xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN xref: Reactome:R-HSA-5696415 "ETNPPL tetramer hydrolyses PETA" xref: RHEA:17889 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050460 name: hydroxylamine reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN] synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10] synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10] synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10] synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] xref: EC:1.7.1.10 xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN xref: RHEA:20581 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050461 name: L-mimosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [EC:2.5.1.52, RHEA:12693] synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52] synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] xref: EC:2.5.1.52 xref: KEGG_REACTION:R04091 xref: MetaCyc:RXN-7461 xref: RHEA:12693 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050462 name: N-acetylneuraminate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN] synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56] synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56] synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56] synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56] xref: EC:2.5.1.56 xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN xref: RHEA:19273 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050463 name: nitrate reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2] synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2] synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2] synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2] synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2] xref: EC:1.7.1.2 is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050464 name: nitrate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3] synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3] synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3] synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3] synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3] xref: EC:1.7.1.3 xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN xref: RHEA:19061 is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity [Term] id: GO:0050465 name: nitroquinoline-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN] synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9] synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] xref: EC:1.7.1.9 xref: MetaCyc:1.7.1.9-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0050466 name: obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" EXACT [] is_obsolete: true consider: GO:0046992 [Term] id: GO:0050467 name: pentalenene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18081] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7] xref: EC:4.2.3.7 xref: KEGG_REACTION:R02305 xref: MetaCyc:PENTALENENE-SYNTHASE-RXN xref: RHEA:18081 is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0050468 name: reticuline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+)." [EC:1.21.3.3, RHEA:19885] synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3] synonym: "BBE" RELATED [EC:1.21.3.3] synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3] synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3] synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3] xref: EC:1.21.3.3 xref: KEGG_REACTION:R03831 xref: MetaCyc:RETICULINE-OXIDASE-RXN xref: RHEA:19885 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0050469 name: sabinene-hydrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19565] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11] synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11] xref: EC:4.2.3.11 xref: KEGG_REACTION:R02006 xref: MetaCyc:4.2.3.11-RXN xref: RHEA:19565 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050470 name: trimethylamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN] synonym: "TMADh activity" RELATED [EC:1.5.8.2] synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2] xref: EC:1.5.8.2 xref: MetaCyc:1.5.8.2-RXN xref: UM-BBD_enzymeID:e0854 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0050471 name: uracilylalanine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN] synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53] synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53] xref: EC:2.5.1.53 xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN xref: RHEA:11496 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050472 name: zeatin reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin." [EC:1.3.1.69, RHEA:12757] synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69] xref: EC:1.3.1.69 xref: KEGG_REACTION:R05702 xref: MetaCyc:ZEATIN-REDUCTASE-RXN xref: RHEA:12757 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050473 name: arachidonate 15-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33] synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33] synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33] synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] xref: EC:1.13.11.33 xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN xref: Reactome:R-HSA-2161951 "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2" xref: Reactome:R-HSA-2162002 "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B" xref: Reactome:R-HSA-9018907 "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3" xref: Reactome:R-HSA-9020261 "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA" xref: Reactome:R-HSA-9020262 "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA" xref: Reactome:R-HSA-9020275 "ALOX15 oxidises DHA to 17(S)-Hp-DHA" xref: Reactome:R-HSA-9020610 "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3" xref: Reactome:R-HSA-9024872 "ALOX15 oxidises 17(S)-Hp-DHA to PDX" xref: Reactome:R-HSA-9024881 "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA" xref: Reactome:R-HSA-9025152 "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6" xref: Reactome:R-HSA-9026003 "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3" xref: Reactome:R-HSA-9027532 "PTGS2 dimer oxidises DHA to 13-HDHA" xref: Reactome:R-HSA-9027607 "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3" xref: Reactome:R-HSA-9027627 "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)" xref: Reactome:R-HSA-9028255 "PTGS2 dimer oxidises EPA to PGH3" xref: RHEA:16869 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050474 name: (S)-norcoclaurine synthase activity namespace: molecular_function alt_id: GO:0050475 def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78] synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78] synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78] xref: EC:4.2.1.78 xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN xref: RHEA:16173 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050476 name: acetylenedicarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78] synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78] xref: EC:4.1.1.78 xref: MetaCyc:4.1.1.78-RXN xref: RHEA:17733 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050477 name: acyl-lysine deacylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17] synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17] synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] xref: EC:3.5.1.17 xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN xref: RHEA:24548 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050478 name: anthranilate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O(2) = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H(2)O." [EC:1.14.16.3, RHEA:21168] synonym: "anthranilate 3-hydroxylase activity" EXACT [] synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3] xref: EC:1.14.16.3 xref: KEGG_REACTION:R01816 xref: MetaCyc:1.14.16.3-RXN xref: RHEA:21168 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050479 name: glyceryl-ether monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN] synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5] synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5] synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5] synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] xref: EC:1.14.16.5 xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN xref: Reactome:R-HSA-5696119 "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050480 name: imidazolonepropionase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+)." [EC:3.5.2.7, RHEA:23660] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7] synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7] synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7] xref: EC:3.5.2.7 xref: KEGG_REACTION:R02288 xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN xref: RHEA:23660 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050481 name: mandelate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21716] synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6] synonym: "L-mandelate 4-hydroxylase activity" EXACT [] synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6] xref: EC:1.14.16.6 xref: KEGG_REACTION:R03794 xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN xref: RHEA:21716 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050482 name: arachidonic acid secretion namespace: biological_process def: "The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai] comment: This term should be used to annotate release of arachidonic acid from the cell. For the hydrolytic release of arachidonic acid from a phospholipid, consider instead annotating to 'phospholipase A2 activity ; GO:0004623'. is_a: GO:0032309 ! icosanoid secretion is_a: GO:1903963 ! arachidonate transport [Term] id: GO:0050483 name: IMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] synonym: "IMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7607 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] id: GO:0050484 name: GMP 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] synonym: "GMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7609 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] id: GO:0050485 name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai] synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT [] xref: EC:1.21.4 is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond [Term] id: GO:0050486 name: intramolecular transferase activity, transferring hydroxy groups namespace: molecular_function def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah] xref: EC:5.4.4 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0050487 name: sulfoacetaldehyde acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde." [EC:2.3.3.15, RHEA:24204] comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15] synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT [] xref: EC:2.3.3.15 xref: KEGG_REACTION:R05651 xref: MetaCyc:RXN-2364 xref: RHEA:24204 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0050488 name: ecdysteroid UDP-glucosyltransferase activity namespace: molecular_function alt_id: GO:0050489 def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711] synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050490 name: 1,4-lactonase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN] synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25] synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25] xref: EC:3.1.1.25 xref: MetaCyc:14-LACTONASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050491 name: sulcatone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone." [EC:1.1.1.260, RHEA:24484] synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260] xref: EC:1.1.1.260 xref: KEGG_REACTION:R05678 xref: MetaCyc:1.1.1.260-RXN xref: RHEA:24484 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050492 name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN] synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261] xref: EC:1.1.1.261 xref: MetaCyc:1.1.1.261-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050493 name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164] synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0164 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0050494 name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165] synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] xref: RESID:AA0165 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042082 ! GSI anchor biosynthetic process [Term] id: GO:0050495 name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346] synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0346 is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0050496 name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine namespace: biological_process def: "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347] synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT [] xref: RESID:AA0340 is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0050497 name: transferase activity, transferring alkylthio groups namespace: molecular_function def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai] xref: EC:2.8.4 is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0050498 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah] xref: EC:1.14.20 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050499 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah] xref: EC:1.20.1 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050500 name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN] synonym: "beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT [] synonym: "beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211] synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211] xref: EC:2.4.1.211 xref: MetaCyc:2.4.1.211-RXN xref: RHEA:20285 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050501 name: hyaluronan synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN] synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212] synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212] synonym: "HAS activity" BROAD [EC:2.4.1.212] synonym: "seHAS" RELATED [EC:2.4.1.212] synonym: "spHAS" RELATED [EC:2.4.1.212] xref: EC:2.4.1.212 xref: MetaCyc:2.4.1.212-RXN xref: Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerisation of HA" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050502 name: cis-zeatin O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP." [EC:2.4.1.215, RHEA:20681] synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] xref: EC:2.4.1.215 xref: KEGG_REACTION:R07260 xref: MetaCyc:RXN-4735 xref: RHEA:20681 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050503 name: trehalose 6-phosphate phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN] synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216] xref: EC:2.4.1.216 xref: MetaCyc:2.4.1.216-RXN xref: RHEA:20864 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0050504 name: mannosyl-3-phosphoglycerate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)." [EC:2.4.1.217, RHEA:13537] synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217] synonym: "MPG synthase activity" EXACT [EC:2.4.1.217] xref: EC:2.4.1.217 xref: KEGG_REACTION:R05768 xref: MetaCyc:2.4.1.217-RXN xref: RHEA:13537 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050505 name: hydroquinone glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12560] synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218] synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] xref: EC:2.4.1.218 xref: KEGG_REACTION:R05769 xref: MetaCyc:2.4.1.218-RXN xref: RHEA:12560 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050506 name: vomilenine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19385] synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219] xref: EC:2.4.1.219 xref: KEGG_REACTION:R05882 xref: MetaCyc:2.4.1.219-RXN xref: RHEA:19385 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050507 name: indoxyl-UDPG glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP." [EC:2.4.1.220, RHEA:12004] synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220] synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220] xref: EC:2.4.1.220 xref: KEGG_REACTION:R06048 xref: MetaCyc:2.4.1.220-RXN xref: RHEA:12004 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050508 name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224] synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] xref: EC:2.4.1.224 xref: MetaCyc:2.4.1.224-RXN xref: Reactome:R-HSA-2022851 "EXT1:EXT2 transfer GlcNAc to the heparan chain" xref: Reactome:R-HSA-2022919 "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue" xref: Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain" xref: Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain" xref: Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue" xref: Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0050509 name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225] synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT [] synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225] synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225] xref: EC:2.4.1.225 xref: MetaCyc:2.4.1.225-RXN xref: Reactome:R-HSA-2022856 "EXT1:EXT2 transfers GlcNAc to heparan" xref: Reactome:R-HSA-2076392 "EXT1:EXT2 transfers GlcA to heparan" xref: Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan" xref: Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" xref: Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan" xref: Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050510 name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226] synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226] synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] xref: EC:2.4.1.226 xref: MetaCyc:2.4.1.226-RXN xref: Reactome:R-HSA-1971491 "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin" xref: Reactome:R-HSA-3595178 "Defective CHSY1 does not transfer GlcA to chondroitin" xref: Reactome:R-HSA-9632034 "CHSY1 transfers GlcA to chondroitin" is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0050511 name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN] comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. synonym: "MurG transferase activity" RELATED [EC:2.4.1.227] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227] synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227] synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.227 xref: MetaCyc:RXN-8976 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0050512 name: lactosylceramide 4-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] synonym: "Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228] synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228] synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228] xref: EC:2.4.1.228 xref: MetaCyc:2.4.1.228-RXN xref: RHEA:11924 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0050513 name: glycoprotein 2-beta-D-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP." [EC:2.4.2.38, RHEA:10612] synonym: "1,2-beta-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT [] xref: EC:2.4.2.38 xref: KEGG_REACTION:R06016 xref: MetaCyc:2.4.2.38-RXN xref: RHEA:10612 is_a: GO:0035252 ! UDP-xylosyltransferase activity [Term] id: GO:0050514 name: homospermidine synthase (spermidine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN] synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45] xref: EC:2.5.1.45 xref: MetaCyc:2.5.1.45-RXN xref: RHEA:11236 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0050515 name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity namespace: molecular_function alt_id: GO:0008698 def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+)." [EC:2.7.1.148, RHEA:18437] synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT [] synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148] synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148] synonym: "CMK activity" RELATED [EC:2.7.1.148] xref: EC:2.7.1.148 xref: KEGG_REACTION:R05634 xref: MetaCyc:2.7.1.148-RXN xref: RHEA:18437 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0050516 name: obsolete inositol polyphosphate multikinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN] comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products. synonym: "ArgRIII" RELATED [EC:2.7.1.151] synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151] synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151] synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151] synonym: "AtIpk2beta" RELATED [EC:2.7.1.151] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.151] synonym: "inositol polyphosphate 6-/3-/5-kinase activity" EXACT [EC:2.7.1.151] synonym: "inositol polyphosphate multikinase activity" EXACT [] synonym: "inositol-polyphosphate multikinase activity" EXACT [] synonym: "IP3/IP4 6-/3-kinase activity" EXACT [EC:2.7.1.151] synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" EXACT [EC:2.7.1.151] synonym: "IpK2 activity" RELATED [EC:2.7.1.151] synonym: "IpmK" RELATED [EC:2.7.1.151] xref: EC:2.7.1.151 xref: MetaCyc:2.7.1.151-RXN is_obsolete: true [Term] id: GO:0050517 name: obsolete inositol hexakisphosphate kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN] comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products. synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.4.21] synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.21] synonym: "inositol hexakisphosphate kinase activity" EXACT [] synonym: "inositol-hexakisphosphate kinase activity" EXACT [] xref: EC:2.7.4.21 xref: MetaCyc:2.7.1.152-RXN is_obsolete: true [Term] id: GO:0050518 name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity namespace: molecular_function alt_id: GO:0008699 def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13429] synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60] synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT [] synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT [] synonym: "MCT activity" RELATED [EC:2.7.7.60] synonym: "MEP cytidylyltransferase activity" EXACT [] xref: EC:2.7.7.60 xref: KEGG_REACTION:R05633 xref: MetaCyc:2.7.7.60-RXN xref: RHEA:13429 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0050519 name: holo-citrate lyase synthase activity namespace: molecular_function def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN] synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61] synonym: "CitX" RELATED [EC:2.7.7.61] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] xref: EC:2.7.7.61 xref: MetaCyc:2.7.7.61-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0050520 name: phosphatidylcholine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)." [EC:2.7.8.24, RHEA:14597] synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] synonym: "PC synthase activity" EXACT [EC:2.7.8.24] xref: EC:2.7.8.24 xref: KEGG_REACTION:R05794 xref: MetaCyc:2.7.8.24-RXN xref: RHEA:14597 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0050521 name: alpha-glucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN] synonym: "a-glucan, water dikinase activity" EXACT [] synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4] synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4] synonym: "GWD" RELATED [EC:2.7.9.4] synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4] xref: EC:2.7.9.4 xref: MetaCyc:2.7.9.4-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0050522 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai] xref: EC:1.20.98 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050523 name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" EXACT [] is_obsolete: true consider: GO:0030613 [Term] id: GO:0050524 name: coenzyme-B sulfoethylthiotransferase activity namespace: molecular_function alt_id: GO:0018552 def: "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12532] synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1] synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT [] synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1] synonym: "methyl-coenzyme-M reductase activity" EXACT [] synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1] xref: EC:2.8.4.1 xref: KEGG_REACTION:R04541 xref: MetaCyc:METHYL-COM-HTP-RXN xref: RHEA:12532 xref: UM-BBD_reactionID:r0356 is_a: GO:0050497 ! transferase activity, transferring alkylthio groups [Term] id: GO:0050525 name: cutinase activity namespace: molecular_function def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN] synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74] xref: EC:3.1.1.74 xref: MetaCyc:3.1.1.74-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050526 name: poly(3-hydroxybutyrate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN] synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75] synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75] synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] xref: EC:3.1.1.75 xref: MetaCyc:3.1.1.75-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050527 name: poly(3-hydroxyoctanoate) depolymerase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN] synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76] synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76] synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76] synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76] xref: EC:3.1.1.76 xref: MetaCyc:3.1.1.76-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050528 name: acyloxyacyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] xref: EC:3.1.1.77 xref: MetaCyc:3.1.1.77-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050529 name: polyneuridine-aldehyde esterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol." [EC:3.1.1.78, RHEA:17501] synonym: "PNAE activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78] synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78] xref: EC:3.1.1.78 xref: KEGG_REACTION:R05825 xref: MetaCyc:3.1.1.78-RXN xref: RHEA:17501 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0050530 name: glucosylglycerol 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22652] synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69] synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69] synonym: "StpA" RELATED [EC:3.1.3.69] xref: EC:3.1.3.69 xref: KEGG_REACTION:R05791 xref: MetaCyc:3.1.3.69-RXN xref: RHEA:22652 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050531 name: mannosyl-3-phosphoglycerate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19309] synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70] xref: EC:3.1.3.70 xref: KEGG_REACTION:R05790 xref: MetaCyc:3.1.3.70-RXN xref: RHEA:19309 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050532 name: 2-phosphosulfolactate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23416] synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] synonym: "2-phosphosulpholactate phosphatase activity" EXACT [] synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71] xref: EC:3.1.3.71 xref: KEGG_REACTION:R05789 xref: MetaCyc:R229-RXN xref: RHEA:23416 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050533 name: 5-phytase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN] synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72] xref: EC:3.1.3.72 xref: MetaCyc:3.1.3.72-RXN xref: RHEA:13001 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0050534 name: 3-deoxyoctulosonase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN] synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144] synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144] xref: EC:3.2.1.144 xref: MetaCyc:3.2.1.144-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050535 name: beta-primeverosidase activity namespace: molecular_function def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN] synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149] synonym: "b-primeverosidase activity" EXACT [] xref: EC:3.2.1.149 xref: MetaCyc:3.2.1.149-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0050536 name: (S)-N-acetyl-1-phenylethylamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23952] synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85] synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85] xref: EC:3.5.1.85 xref: KEGG_REACTION:R07301 xref: MetaCyc:3.5.1.85-RXN xref: RHEA:23952 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050537 name: mandelamide amidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+)." [EC:3.5.1.86, RHEA:22876] synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86] synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86] xref: EC:3.5.1.86 xref: KEGG_REACTION:R05783 xref: MetaCyc:3.5.1.86-RXN xref: RHEA:22876 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050538 name: N-carbamoyl-L-amino-acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN] synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87] synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87] xref: EC:3.5.1.87 xref: MetaCyc:3.5.1.87-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050539 name: maleimide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate." [EC:3.5.2.16, RHEA:24476] synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16] synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16] synonym: "imidase activity" BROAD [EC:3.5.2.16] xref: EC:3.5.2.16 xref: KEGG_REACTION:R05781 xref: MetaCyc:3.5.2.16-RXN xref: RHEA:24476 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0050540 name: 2-aminomuconate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+)." [EC:3.5.99.5, RHEA:20996] synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5] xref: EC:3.5.99.5 xref: KEGG_REACTION:R03887 xref: MetaCyc:3.5.99.5-RXN xref: RHEA:20996 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0050541 name: beta,beta-carotene-9',10'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918] synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT [] is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050542 name: icosanoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732] synonym: "eicosanoid binding" EXACT [] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:1901567 ! fatty acid derivative binding [Term] id: GO:0050543 name: icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732] synonym: "eicosatetraenoic acid binding" EXACT [] is_a: GO:0036041 ! long-chain fatty acid binding [Term] id: GO:0050544 name: arachidonic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai] synonym: "arachidonate binding" EXACT [] is_a: GO:0050542 ! icosanoid binding is_a: GO:0050543 ! icosatetraenoic acid binding [Term] id: GO:0050545 name: sulfopyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20948] synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79] synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79] synonym: "sulphopyruvate decarboxylase activity" EXACT [] xref: EC:4.1.1.79 xref: KEGG_REACTION:R05774 xref: MetaCyc:R231-RXN xref: RHEA:20948 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050546 name: 4-hydroxyphenylpyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2)." [EC:4.1.1.80, RHEA:18697] synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80] synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80] xref: EC:4.1.1.80 xref: KEGG_REACTION:R03341 xref: MetaCyc:4.1.1.80-RXN xref: RHEA:18697 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050547 name: vanillin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin." [EC:4.1.2.41, RHEA:18725] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] xref: EC:4.1.2.41 xref: KEGG_REACTION:R05773 xref: MetaCyc:4.1.2.41-RXN xref: RHEA:18725 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0050548 name: trans-feruloyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN] synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101] synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101] xref: EC:4.2.1.101 xref: MetaCyc:4.2.1.101-RXN xref: RHEA:14517 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050549 name: cyclohexyl-isocyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O." [EC:4.2.1.103, RHEA:18197] synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103] synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103] xref: EC:4.2.1.103 xref: KEGG_REACTION:R05771 xref: MetaCyc:4.2.1.103-RXN xref: RHEA:18197 xref: UM-BBD_reactionID:r1029 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0050550 name: pinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN] synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14] synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14] synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14] synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14] xref: EC:4.2.3.14 xref: MetaCyc:4.2.3.14-RXN is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050551 name: myrcene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene." [EC:4.2.3.15, RHEA:16965] synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT [] xref: EC:4.2.3.15 xref: KEGG_REACTION:R02009 xref: MetaCyc:RXN-5110 xref: RHEA:16965 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050552 name: (4S)-limonene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN] synonym: "(-)-(4S)-limonene synthase activity" EXACT [] synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16] synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16] synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16] xref: EC:4.2.3.16 xref: MetaCyc:4.2.3.16-RXN xref: RHEA:12869 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0050553 name: taxadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20912] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17] synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17] synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17] xref: EC:4.2.3.17 xref: KEGG_REACTION:R06305 xref: MetaCyc:4.2.3.17-RXN xref: RHEA:20912 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050554 name: abietadiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13873] synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18] synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18] synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18] xref: EC:4.2.3.18 xref: KEGG_REACTION:R06301 xref: MetaCyc:4.2.3.18-RXN xref: RHEA:13873 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0050555 name: 2-hydroxypropyl-CoM lyase activity namespace: molecular_function def: "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN] synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23] synonym: "EaCoMT activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23] xref: EC:4.4.1.23 xref: MetaCyc:4.2.99.19-RXN xref: UM-BBD_enzymeID:e0538 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0050556 name: deacetylisoipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.3, RHEA:21756] synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3] synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3] xref: EC:4.3.3.3 xref: KEGG_REACTION:R05750 xref: MetaCyc:4.3.3.3-RXN xref: RHEA:21756 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0050557 name: deacetylipecoside synthase activity namespace: molecular_function def: "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.4, RHEA:12296] synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4] synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4] xref: EC:4.3.3.4 xref: KEGG_REACTION:R05749 xref: MetaCyc:4.3.3.4-RXN xref: RHEA:12296 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0050558 name: maltose epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, RHEA:21228] synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21] xref: EC:5.1.3.21 xref: KEGG_REACTION:R07319 xref: MetaCyc:5.1.3.21-RXN xref: RHEA:21228 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0050559 name: copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24316] synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12] synonym: "diterpene cyclase activity" BROAD [] xref: EC:5.5.1.12 xref: KEGG_REACTION:R06298 xref: MetaCyc:RXN-4861 xref: RHEA:24316 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0050560 name: aspartate-tRNA(Asn) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN] synonym: "aspartate-tRNAAsn ligase activity" EXACT [] synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23] synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] xref: EC:6.1.1.23 xref: MetaCyc:6.1.1.23-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050561 name: glutamate-tRNA(Gln) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN] synonym: "glutamate-tRNAGln ligase activity" EXACT [] synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24] synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24] xref: EC:6.1.1.24 xref: MetaCyc:6.1.1.24-RXN xref: RHEA:18397 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050562 name: lysine-tRNA(Pyl) ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [MetaCyc:6.1.1.25-RXN] synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [] synonym: "lysine-tRNAPyl ligase activity" EXACT [] xref: MetaCyc:6.1.1.25-RXN is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0050563 name: trans-feruloyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN] synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34] synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34] xref: EC:6.2.1.34 xref: MetaCyc:6.2.1.34-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0050564 name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+)." [EC:6.3.2.26, RHEA:23196] synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26] synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26] synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26] synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26] xref: EC:6.3.2.26 xref: KEGG_REACTION:R04870 xref: MetaCyc:6.3.2.26-RXN xref: RHEA:23196 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050565 name: aerobactin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate." [RHEA:11760] synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [] synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [] xref: KEGG_REACTION:R04357 xref: MetaCyc:6.3.2.27-RXN xref: RHEA:11760 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0050566 name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN] synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] xref: EC:6.3.5.6 xref: MetaCyc:6.3.5.6-RXN xref: RHEA:14513 xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0050567 name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity namespace: molecular_function alt_id: GO:0008264 alt_id: GO:0017068 def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] xref: EC:6.3.5.7 xref: MetaCyc:6.3.5.7-RXN xref: RHEA:17521 xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0050568 name: protein-glutamine glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN] synonym: "destabilase activity" EXACT [EC:3.5.1.44] synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44] synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44] synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44] synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44] xref: EC:3.5.1.44 xref: MetaCyc:CHEBDEAMID-RXN xref: RHEA:16441 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0050569 name: glycolaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH." [EC:1.2.1.21, RHEA:20001] synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21] synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21] xref: EC:1.2.1.21 xref: KEGG_REACTION:R01333 xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN xref: RHEA:20001 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity [Term] id: GO:0050570 name: 4-hydroxythreonine-4-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN] synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262] synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] synonym: "PdxA" RELATED [EC:1.1.1.262] xref: EC:1.1.1.262 xref: MetaCyc:1.1.1.262-RXN xref: RHEA:25319 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050571 name: 1,5-anhydro-D-fructose reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.263, RHEA:20665] synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263] synonym: "AF reductase activity" EXACT [EC:1.1.1.263] xref: EC:1.1.1.263 xref: KEGG_REACTION:R05682 xref: MetaCyc:1.1.1.263-RXN xref: RHEA:20665 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050572 name: L-idonate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN] synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264] xref: EC:1.1.1.264 xref: MetaCyc:1.1.1.264-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050573 name: dTDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903] synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266] synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266] xref: EC:1.1.1.266 xref: KEGG_REACTION:R05687 xref: MetaCyc:1.1.1.266-RXN xref: RHEA:21903 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050574 name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.268, RHEA:13249] synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268] synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268] xref: EC:1.1.1.268 xref: KEGG_REACTION:R05689 xref: MetaCyc:1.1.1.268-RXN xref: RHEA:13249 xref: UM-BBD_reactionID:r0852 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050575 name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.269, RHEA:21052] synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269] synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269] xref: EC:1.1.1.269 xref: KEGG_REACTION:R05690 xref: MetaCyc:1.1.1.269-RXN xref: RHEA:21052 xref: UM-BBD_reactionID:r0853 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050577 name: GDP-L-fucose synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN] synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271] synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271] synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271] xref: EC:1.1.1.271 xref: MetaCyc:1.1.1.271-RXN xref: Reactome:R-HSA-6787642 "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc" xref: RHEA:18885 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0042350 ! GDP-L-fucose biosynthetic process [Term] id: GO:0050578 name: (R)-2-hydroxyacid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN] synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272] xref: EC:1.1.1.272 xref: MetaCyc:1.1.1.272-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050579 name: vellosimine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20029] synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273] xref: EC:1.1.1.273 xref: KEGG_REACTION:R05827 xref: MetaCyc:1.1.1.273-RXN xref: RHEA:20029 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050580 name: 2,5-didehydrogluconate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN] synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274] synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274] synonym: "YqhE reductase" RELATED [EC:1.1.1.274] xref: EC:1.1.1.274 xref: MetaCyc:1.1.1.274-RXN xref: RHEA:23828 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050581 name: D-mannitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN] synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40] synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40] synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40] xref: EC:1.1.3.40 xref: MetaCyc:1.1.3.40-RXN xref: RHEA:18513 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050582 name: xylitol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN] synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41] xref: EC:1.1.3.41 xref: MetaCyc:1.1.3.41-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0050583 name: hydrogen dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN] synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3] synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3] synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3] xref: EC:1.12.1.3 xref: MetaCyc:1.12.1.3-RXN xref: RHEA:18637 is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: GO:0050584 name: linoleate 11-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18993] synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45] synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45] synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45] xref: EC:1.13.11.45 xref: KEGG_REACTION:R05718 xref: MetaCyc:1.13.11.45-RXN xref: RHEA:18993 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050585 name: 4-hydroxymandelate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN] synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46] xref: EC:1.13.11.46 xref: MetaCyc:1.13.11.46-RXN xref: RHEA:21376 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050586 name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21572] synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48] synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT [] synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [] synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48] synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT [] xref: EC:1.13.11.48 xref: KEGG_REACTION:R05720 xref: MetaCyc:1.13.11.48-RXN xref: RHEA:21572 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050587 name: chlorite O2-lyase activity namespace: molecular_function alt_id: GO:0030065 def: "Catalysis of the reaction: chloride + O(2) = chlorite." [EC:1.13.11.49, RHEA:21404] synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49] synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49] xref: EC:1.13.11.49 xref: KEGG_REACTION:R05721 xref: MetaCyc:1.13.11.49-RXN xref: RHEA:21404 xref: UM-BBD_reactionID:r0982 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0050588 name: apo-beta-carotenoid-14',13'-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.11.67, RHEA:26023] synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.11.67] synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT [] xref: EC:1.13.11.67 xref: KEGG_REACTION:R08889 xref: MetaCyc:1.13.12.12-RXN xref: RHEA:26023 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0050589 name: leucocyanidin oxygenase activity namespace: molecular_function alt_id: GO:0045432 def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.20.4, MetaCyc:1.14.11.19-RXN] synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.20.4] synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.20.4] synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.20.4] synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.20.4] xref: EC:1.14.20.4 xref: MetaCyc:RXN-602 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0050590 name: desacetoxyvindoline 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN] synonym: "D17H activity" RELATED [EC:1.14.11.20] synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20] synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20] xref: EC:1.14.11.20 xref: KEGG_REACTION:R05857 xref: MetaCyc:1.14.11.20-RXN xref: RHEA:18973 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0050591 name: quinine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.14.55, RHEA:20149] synonym: "nifedipine oxidase activity" EXACT [EC:1.14.14.55] synonym: "quinine 3-hydroxylase activity" EXACT [] synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.14.55] xref: EC:1.14.14.55 xref: KEGG_REACTION:R05727 xref: MetaCyc:1.14.13.67-RXN xref: RHEA:20149 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050592 name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)." [EC:1.14.14.37, RHEA:18401] synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.14.37] synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.14.37] synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.14.37] synonym: "CYP71E1 activity" NARROW [EC:1.14.14.37] synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.14.37] synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.14.37] synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.14.37] xref: EC:1.14.14.37 xref: KEGG_REACTION:R05728 xref: MetaCyc:1.14.13.68-RXN xref: RHEA:18401 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050593 name: N-methylcoclaurine 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)." [EC:1.14.14.102, RHEA:16649] synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.14.102] synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.102] synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.14.102] synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT [] xref: EC:1.14.14.102 xref: KEGG_REACTION:R05732 xref: MetaCyc:1.14.13.71-RXN xref: RHEA:16649 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050594 name: tabersonine 16-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)." [EC:1.14.14.103, RHEA:14133] synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.14.103] xref: EC:1.14.14.103 xref: KEGG_REACTION:R05855 xref: MetaCyc:1.14.13.73-RXN xref: RHEA:14133 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050595 name: 7-deoxyloganin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN] synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74] xref: EC:1.14.13.74 xref: MetaCyc:1.14.13.74-RXN xref: RHEA:11452 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050596 name: vinorine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine." [EC:1.14.14.104, RHEA:17257] synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.14.104] xref: EC:1.14.14.104 xref: KEGG_REACTION:R05877 xref: MetaCyc:1.14.13.75-RXN xref: RHEA:17257 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050597 name: taxane 10-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)." [EC:1.14.14.105, RHEA:15241] synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.14.105] synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.14.105] synonym: "taxane 10b-hydroxylase activity" EXACT [] synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.14.105] xref: EC:1.14.14.105 xref: KEGG_REACTION:R06309 xref: MetaCyc:1.14.13.76-RXN xref: RHEA:15241 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050598 name: taxane 13-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.14.106, RHEA:18949] synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.14.106] synonym: "taxane 13a-hydroxylase activity" EXACT [] synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.14.106] xref: EC:1.14.14.106 xref: KEGG_REACTION:R06308 xref: MetaCyc:1.14.13.77-RXN xref: RHEA:18949 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0050599 name: deacetoxycephalosporin-C synthase activity namespace: molecular_function alt_id: GO:0045441 def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate." [EC:1.14.20.1, RHEA:20748] synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1] synonym: "DAOCS activity" EXACT [EC:1.14.20.1] synonym: "deacetoxycephalosporin C synthetase activity" EXACT [] synonym: "expandase activity" EXACT [] synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1] synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1] xref: EC:1.14.20.1 xref: KEGG_REACTION:R05301 xref: MetaCyc:1.14.20.1-RXN xref: RHEA:20748 is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [Term] id: GO:0050600 name: myristoyl-CoA 11-(E) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.19.24, MetaCyc:1.14.99.31-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.19.24] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] xref: EC:1.14.19.24 xref: MetaCyc:1.14.99.31-RXN xref: RHEA:46396 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050601 name: myristoyl-CoA 11-(Z) desaturase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.19.5, MetaCyc:1.14.99.32-RXN] synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.19.5] synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.19.5] xref: EC:1.14.19.5 xref: MetaCyc:1.14.99.32-RXN xref: RHEA:25852 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050602 name: monoprenyl isoflavone epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN] synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34] xref: EC:1.14.99.34 xref: MetaCyc:1.14.99.34-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050603 name: thiophene-2-carbonyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+)." [EC:1.14.99.35, RHEA:18929] synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35] synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35] xref: EC:1.14.99.35 xref: KEGG_REACTION:R05742 xref: MetaCyc:1.14.99.35-RXN xref: RHEA:18929 xref: UM-BBD_reactionID:r1235 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050604 name: taxadiene 5-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." [EC:1.14.99.37, RHEA:14049] synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37] synonym: "taxadiene 5a-hydroxylase activity" EXACT [] synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37] xref: EC:1.14.99.37 xref: KEGG_REACTION:R06306 xref: MetaCyc:1.14.99.37-RXN xref: RHEA:14049 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0050605 name: superoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN] synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2] synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2] xref: EC:1.15.1.2 xref: MetaCyc:1.15.1.2-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0050606 name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH." [RHEA:29587] synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312] synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.312] synonym: "4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312] synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.1.1.312] xref: EC:1.1.1.312 xref: KEGG_REACTION:R04279 xref: MetaCyc:1.2.1.45-RXN xref: RHEA:29587 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0050607 name: mycothiol-dependent formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.1.1.306, MetaCyc:1.2.1.66-RXN] synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [] synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.306] xref: EC:1.1.1.306 xref: MetaCyc:1.2.1.66-RXN xref: RHEA:28502 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050608 name: vanillin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate." [EC:1.2.1.67, RHEA:13309] synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67] xref: EC:1.2.1.67 xref: KEGG_REACTION:R05699 xref: MetaCyc:1.2.1.67-RXN xref: RHEA:13309 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0050609 name: phosphonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate." [EC:1.20.1.1, RHEA:13173] synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1] synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1] synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1] synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1] xref: EC:1.20.1.1 xref: KEGG_REACTION:R05746 xref: MetaCyc:1.20.1.1-RXN xref: RHEA:13173 xref: UM-BBD_reactionID:r1055 is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor [Term] id: GO:0050610 name: methylarsonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid." [EC:1.20.4.2, RHEA:15969] synonym: "glutathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2] synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2] xref: EC:1.20.4.2 xref: KEGG_REACTION:R05748 xref: MetaCyc:1.20.4.2-RXN xref: Reactome:R-HSA-5696230 "GSTO1 dimer reduces methylarsonate to methylarsonite" xref: RHEA:15969 xref: UM-BBD_reactionID:r0837 is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [Term] id: GO:0050611 name: arsenate reductase (azurin) activity namespace: molecular_function alt_id: GO:0018691 def: "Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate." [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN] synonym: "arsenite oxidase activity" EXACT [EC:1.20.9.1] synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.9.1] xref: EC:1.20.9.1 xref: MetaCyc:1.20.98.1-RXN xref: UM-BBD_reactionID:r0634 is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor [Term] id: GO:0050612 name: arsenate reductase (donor) activity namespace: molecular_function def: "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+)." [EC:1.20.99.1, RHEA:18449] synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1] synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1] xref: EC:1.20.99.1 xref: KEGG_REACTION:R05752 xref: MetaCyc:1.20.99.1-RXN xref: RHEA:18449 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0050613 name: delta14-sterol reductase activity namespace: molecular_function alt_id: GO:0000251 def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70] synonym: "C-14 sterol reductase activity" EXACT [] synonym: "D14-sterol reductase activity" EXACT [] synonym: "sterol C-14 reductase activity" EXACT [] synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70] xref: EC:1.3.1.70 xref: MetaCyc:1.3.1.70-RXN xref: Reactome:R-HSA-194674 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]" xref: Reactome:R-HSA-194698 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]" xref: RHEA:18561 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050614 name: delta24-sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN] synonym: "D24-sterol reductase activity" EXACT [] synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72] synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72] synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72] xref: EC:1.3.1.72 xref: MetaCyc:1.3.1.72-RXN xref: Reactome:R-HSA-196417 "Reduction of desmosterol to cholesterol" xref: Reactome:R-HSA-6807064 "DHCR24 reduces ZYMOL to ZYMSTNL" xref: RHEA:13685 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050615 name: 1,2-dihydrovomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH." [EC:1.3.1.73, RHEA:12320] synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73] xref: EC:1.3.1.73 xref: KEGG_REACTION:R05879 xref: MetaCyc:1.3.1.73-RXN xref: RHEA:12320 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0050616 name: secologanin synthase activity namespace: molecular_function def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.14.19.62, MetaCyc:1.3.3.9-RXN] synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.14.19.62] xref: EC:1.14.19.62 xref: MetaCyc:1.3.3.9-RXN xref: RHEA:20585 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050617 name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN] synonym: "PebA" RELATED [EC:1.3.7.2] xref: EC:1.3.7.2 xref: MetaCyc:1.3.7.2-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050618 name: phycoerythrobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN] synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3] synonym: "PebB" RELATED [EC:1.3.7.3] xref: EC:1.3.7.3 xref: MetaCyc:1.3.7.3-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050619 name: phytochromobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN] synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4] synonym: "HY2" RELATED [EC:1.3.7.4] synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4] synonym: "PFB synthase activity" EXACT [EC:1.3.7.4] synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4] synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4] xref: EC:1.3.7.4 xref: MetaCyc:1.3.7.4-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050620 name: phycocyanobilin:ferredoxin oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN] synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5] xref: EC:1.3.7.5 xref: MetaCyc:1.3.7.5-RXN is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0050621 name: tryptophan alpha,beta-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+)." [EC:1.3.3.10, RHEA:19901] comment: Note that this was EC:1.4.3.17. synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10] synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10] synonym: "tryptophan a,b-oxidase activity" EXACT [] xref: EC:1.3.3.10 xref: KEGG_REACTION:R05317 xref: MetaCyc:1.4.3.17-RXN xref: RHEA:19901 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0050622 name: glycine dehydrogenase (cyanide-forming) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN] synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5] synonym: "HCN synthase activity" EXACT [EC:1.4.99.5] synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5] xref: EC:1.4.99.5 xref: MetaCyc:1.4.99.5-RXN xref: RHEA:15821 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0050623 name: berberine reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH." [EC:1.5.1.31, RHEA:21268] synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31] synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31] xref: EC:1.5.1.31 xref: KEGG_REACTION:R07169 xref: MetaCyc:1.5.1.31-RXN xref: RHEA:21268 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050624 name: vomilenine reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16409] synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32] xref: EC:1.5.1.32 xref: KEGG_REACTION:R05878 xref: MetaCyc:1.5.1.32-RXN xref: RHEA:16409 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0050625 name: 2-hydroxy-1,4-benzoquinone reductase activity namespace: molecular_function alt_id: GO:0018540 def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)." [EC:1.6.5.7, RHEA:12428] synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7] synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-] synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7] xref: EC:1.6.5.7 xref: KEGG_REACTION:R05399 xref: MetaCyc:1.6.5.7-RXN xref: RHEA:12428 xref: UM-BBD_reactionID:r0667 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0050626 name: trimethylamine-N-oxide reductase (cytochrome c) activity namespace: molecular_function def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN] synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3] synonym: "TOR activity" EXACT [EC:1.7.2.3] synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3] xref: EC:1.7.2.3 xref: MetaCyc:1.7.2.3-RXN xref: Wikipedia:Trimethylamine_N-oxide_reductase is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0050627 name: mycothione reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN] synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15] synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15] xref: EC:1.8.1.15 xref: MetaCyc:1.8.1.15-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050628 name: 2-oxopropyl-CoM reductase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH." [EC:1.8.1.5, RHEA:16977] synonym: "2-KPCC activity" EXACT [EC:1.8.1.5] synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5] synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] xref: EC:1.8.1.5 xref: KEGG_REACTION:R05713 xref: MetaCyc:1.8.1.5-RXN xref: RHEA:16977 xref: UM-BBD_reactionID:r0854 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0050629 name: tetrachloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.21.99.5, MetaCyc:1.97.1.8-RXN] synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8] synonym: "tetrachloroethene reductase activity" EXACT [EC:1.21.99.5] xref: EC:1.21.99.5 xref: MetaCyc:1.97.1.8-RXN xref: RHEA:20353 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050630 name: (iso)eugenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN] synonym: "isoeugenol O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146] xref: EC:2.1.1.146 xref: MetaCyc:2.1.1.146-RXN xref: RHEA:17081 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0050631 name: corydaline synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+)." [EC:2.1.1.147, RHEA:14773] synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147] xref: EC:2.1.1.147 xref: KEGG_REACTION:R07241 xref: MetaCyc:2.1.1.147-RXN xref: RHEA:14773 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0050632 name: propionyl-CoA C2-trimethyltridecanoyltransferase activity namespace: molecular_function alt_id: GO:0004770 def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.176, RHEA:10408] synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.176] synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.176] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.176] synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.176] synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.176] synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.176] synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.176] synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT [] synonym: "SCPx" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein" RELATED [EC:2.3.1.176] synonym: "sterol carrier protein X-related thiolase activity" RELATED [] xref: EC:2.3.1.176 xref: KEGG_REACTION:R05330 xref: MetaCyc:2.3.1.154-RXN xref: Reactome:R-HSA-192341 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA" xref: Reactome:R-HSA-193533 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA" xref: Reactome:R-HSA-2066781 "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)" xref: Reactome:R-HSA-390224 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA" xref: RHEA:10408 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050633 name: acetyl-CoA C-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN] synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155] synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155] synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155] xref: EC:2.3.1.155 xref: MetaCyc:2.3.1.155-RXN xref: RHEA:18161 is_a: GO:0016408 ! C-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0050634 name: phloroisovalerophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN] synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156] synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156] synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156] xref: EC:2.3.1.156 xref: MetaCyc:2.3.1.156-RXN xref: RHEA:23572 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050635 name: acridone synthase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O." [EC:2.3.1.159, RHEA:22224] synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159] xref: EC:2.3.1.159 xref: KEGG_REACTION:R07250 xref: MetaCyc:2.3.1.159-RXN xref: RHEA:22224 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050636 name: vinorine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24016] synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160] xref: EC:2.3.1.160 xref: KEGG_REACTION:R05876 xref: MetaCyc:2.3.1.160-RXN xref: RHEA:24016 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050637 name: lovastatin nonaketide synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+)." [EC:2.3.1.161, RHEA:18565] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161] xref: EC:2.3.1.161 xref: KEGG_REACTION:R07251 xref: MetaCyc:2.3.1.161-RXN xref: RHEA:18565 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050638 name: taxadien-5-alpha-ol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22028] synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT [] synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162] xref: EC:2.3.1.162 xref: KEGG_REACTION:R06307 xref: MetaCyc:2.3.1.162-RXN xref: RHEA:22028 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050639 name: 10-hydroxytaxane O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18837] synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163] xref: EC:2.3.1.163 xref: KEGG_REACTION:R07252 xref: MetaCyc:2.3.1.163-RXN xref: RHEA:18837 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050640 name: isopenicillin-N N-acyltransferase activity namespace: molecular_function alt_id: GO:0042319 alt_id: GO:0045440 def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN] synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164] synonym: "isopenicillin-N acyltransferase activity" EXACT [] xref: EC:2.3.1.164 xref: MetaCyc:2.3.1.164-RXN xref: RHEA:20720 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0050641 name: 6-methylsalicylic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+)." [EC:2.3.1.165, RHEA:12240] synonym: "6-MSAS activity" EXACT [EC:2.3.1.165] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165] synonym: "MSAS activity" EXACT [EC:2.3.1.165] xref: EC:2.3.1.165 xref: KEGG_REACTION:R07253 xref: MetaCyc:2.3.1.165-RXN xref: RHEA:12240 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050642 name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [EC:2.3.1.166, RHEA:18741] synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166] synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [] synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] xref: EC:2.3.1.166 xref: KEGG_REACTION:R06310 xref: MetaCyc:2.3.1.166-RXN xref: RHEA:18741 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050643 name: 10-deacetylbaccatin III 10-O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20137] synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167] xref: EC:2.3.1.167 xref: KEGG_REACTION:R06311 xref: MetaCyc:2.3.1.167-RXN xref: RHEA:20137 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0050644 name: cis-p-coumarate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP." [EC:2.4.1.209, RHEA:13129] synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209] xref: EC:2.4.1.209 xref: KEGG_REACTION:R05324 xref: MetaCyc:2.4.1.209-RXN xref: RHEA:13129 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050645 name: limonoid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210] synonym: "LGTase activity" EXACT [EC:2.4.1.210] synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210] synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210] xref: EC:2.4.1.210 xref: MetaCyc:2.4.1.210-RXN xref: RHEA:11256 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0050646 name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0036041 ! long-chain fatty acid binding is_a: GO:0050542 ! icosanoid binding [Term] id: GO:0050647 name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0036041 ! long-chain fatty acid binding is_a: GO:0050542 ! icosanoid binding [Term] id: GO:0050648 name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] is_a: GO:0036041 ! long-chain fatty acid binding is_a: GO:0050542 ! icosanoid binding [Term] id: GO:0050649 name: testosterone 6-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664] synonym: "testosterone 6b-hydroxylase activity" EXACT [] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0050650 name: chondroitin sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] synonym: "chondroitin sulfate proteoglycan anabolism" EXACT [] synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulfate proteoglycan formation" EXACT [] synonym: "chondroitin sulfate proteoglycan synthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT [] is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0050651 name: dermatan sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT [] synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT [] synonym: "dermatan sulfate proteoglycan anabolism" EXACT [] synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT [] synonym: "dermatan sulfate proteoglycan formation" EXACT [] synonym: "dermatan sulfate proteoglycan synthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT [] is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process [Term] id: GO:0050652 name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602] synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT [] synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "dermatan sulfate proteoglycan chain elongation" EXACT [] synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process [Term] id: GO:0050653 name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602] synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT [] synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process [Term] id: GO:0050654 name: chondroitin sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] synonym: "chondroitin sulfate proteoglycan metabolism" EXACT [] synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT [] synonym: "chondroitin sulphate proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process [Term] id: GO:0050655 name: dermatan sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT [] synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT [] synonym: "dermatan sulfate proteoglycan metabolism" EXACT [] synonym: "dermatan sulphate proteoglycan metabolic process" EXACT [] synonym: "dermatan sulphate proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process [Term] id: GO:0050656 name: 3'-phosphoadenosine 5'-phosphosulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai] synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT [] synonym: "3'-phosphoadenylyl-sulfate binding" EXACT [] synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT [] synonym: "PAPS binding" EXACT [] synonym: "phosphoadenosine phosphosulfate binding" EXACT [] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: MIPS_funcat:20.01.21 is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization [Term] id: GO:0050659 name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33] comment: Consider instead annotating to the individual reactions: 'chondroitin 6-sulfotransferase activity ; GO:0008459' and 'dermatan 6-sulfotransferase activity ; GO:0036443'. synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33] synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33] synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33] xref: EC:2.8.2.33 xref: KEGG_REACTION:R02181 xref: KEGG_REACTION:R07288 xref: MetaCyc:RXN-7953 xref: MetaCyc:RXN-7954 xref: Reactome:R-HSA-2018659 "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050660 name: flavin adenine dinucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732] synonym: "FAD or FADH2 binding" EXACT [] synonym: "flavine-adenine dinucleotide binding" EXACT [] xref: MIPS_funcat:16.21.05 is_a: GO:0000166 ! nucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050661 name: NADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] synonym: "NADP or NADPH binding" RELATED [GOC:mah] synonym: "NADP+ or NADPH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] xref: MIPS_funcat:16.21.07 is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050662 name: coenzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] subset: goslim_metagenomics is_a: GO:0048037 ! cofactor binding [Term] id: GO:0050663 name: cytokine secretion namespace: biological_process def: "The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001816 ! cytokine production [Term] id: GO:0050664 name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] synonym: "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor" RELATED [] xref: EC:1.6.3 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0050665 name: hydrogen peroxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai] synonym: "H2O2 biosynthetic process" EXACT [GOC:mah] synonym: "hydrogen peroxide anabolism" EXACT [] synonym: "hydrogen peroxide biosynthesis" EXACT [] synonym: "hydrogen peroxide formation" EXACT [] synonym: "hydrogen peroxide generation" EXACT [] synonym: "hydrogen peroxide synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process [Term] id: GO:0050666 name: regulation of homocysteine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai] synonym: "regulation of Hcy metabolic process" EXACT [] synonym: "regulation of Hcy metabolism" EXACT [] synonym: "regulation of homocysteine metabolism" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050667 ! homocysteine metabolic process relationship: regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050667 name: homocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732] synonym: "Hcy metabolic process" EXACT [] synonym: "Hcy metabolism" EXACT [] synonym: "homocysteine metabolism" EXACT [] xref: MIPS_funcat:01.01.06.05.01.01 is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0050668 name: positive regulation of homocysteine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] synonym: "activation of homocysteine metabolic process" NARROW [] synonym: "positive regulation of Hcy metabolic process" EXACT [] synonym: "positive regulation of Hcy metabolism" EXACT [] synonym: "positive regulation of homocysteine metabolism" EXACT [] synonym: "stimulation of homocysteine metabolic process" NARROW [] synonym: "up regulation of homocysteine metabolic process" EXACT [] synonym: "up-regulation of homocysteine metabolic process" EXACT [] synonym: "upregulation of homocysteine metabolic process" EXACT [] is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process is_a: GO:0050666 ! regulation of homocysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050667 ! homocysteine metabolic process relationship: positively_regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050669 name: negative regulation of homocysteine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] synonym: "down regulation of homocysteine metabolic process" EXACT [] synonym: "down-regulation of homocysteine metabolic process" EXACT [] synonym: "downregulation of homocysteine metabolic process" EXACT [] synonym: "inhibition of homocysteine metabolic process" NARROW [] synonym: "negative regulation of Hcy metabolic process" EXACT [] synonym: "negative regulation of Hcy metabolism" EXACT [] synonym: "negative regulation of homocysteine metabolism" EXACT [] is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process is_a: GO:0050666 ! regulation of homocysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050667 ! homocysteine metabolic process relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process [Term] id: GO:0050670 name: regulation of lymphocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046651 ! lymphocyte proliferation relationship: regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050671 name: positive regulation of lymphocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "activation of lymphocyte proliferation" NARROW [] synonym: "stimulation of lymphocyte proliferation" NARROW [] synonym: "up regulation of lymphocyte proliferation" EXACT [] synonym: "up-regulation of lymphocyte proliferation" EXACT [] synonym: "upregulation of lymphocyte proliferation" EXACT [] is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046651 ! lymphocyte proliferation relationship: positively_regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "down regulation of lymphocyte proliferation" EXACT [] synonym: "down-regulation of lymphocyte proliferation" EXACT [] synonym: "downregulation of lymphocyte proliferation" EXACT [] synonym: "inhibition of lymphocyte proliferation" NARROW [] is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046651 ! lymphocyte proliferation relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0050674 name: urothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050675 name: regulation of urothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050674 ! urothelial cell proliferation relationship: regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050676 name: negative regulation of urothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "down regulation of urothelial cell proliferation" EXACT [] synonym: "down-regulation of urothelial cell proliferation" EXACT [] synonym: "downregulation of urothelial cell proliferation" EXACT [] synonym: "inhibition of urothelial cell proliferation" NARROW [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050674 ! urothelial cell proliferation relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050677 name: positive regulation of urothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai] synonym: "activation of urothelial cell proliferation" NARROW [] synonym: "stimulation of urothelial cell proliferation" NARROW [] synonym: "up regulation of urothelial cell proliferation" EXACT [] synonym: "up-regulation of urothelial cell proliferation" EXACT [] synonym: "upregulation of urothelial cell proliferation" EXACT [] is_a: GO:0050675 ! regulation of urothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050674 ! urothelial cell proliferation relationship: positively_regulates GO:0050674 ! urothelial cell proliferation [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050673 ! epithelial cell proliferation relationship: regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050673 ! epithelial cell proliferation relationship: positively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050673 ! epithelial cell proliferation relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation [Term] id: GO:0050681 name: androgen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an androgen receptor." [GOC:ai] synonym: "AR binding" EXACT [] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0050682 name: AF-2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050683 name: AF-1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050684 name: regulation of mRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006397 ! mRNA processing relationship: regulates GO:0006397 ! mRNA processing [Term] id: GO:0050685 name: positive regulation of mRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] synonym: "activation of mRNA processing" NARROW [] synonym: "stimulation of mRNA processing" NARROW [] synonym: "up regulation of mRNA processing" EXACT [] synonym: "up-regulation of mRNA processing" EXACT [] synonym: "upregulation of mRNA processing" EXACT [] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0050684 ! regulation of mRNA processing is_a: GO:1903313 ! positive regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006397 ! mRNA processing relationship: positively_regulates GO:0006397 ! mRNA processing [Term] id: GO:0050686 name: negative regulation of mRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] synonym: "down regulation of mRNA processing" EXACT [] synonym: "down-regulation of mRNA processing" EXACT [] synonym: "downregulation of mRNA processing" EXACT [] synonym: "inhibition of mRNA processing" NARROW [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0050684 ! regulation of mRNA processing is_a: GO:1903312 ! negative regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006397 ! mRNA processing relationship: negatively_regulates GO:0006397 ! mRNA processing [Term] id: GO:0050687 name: negative regulation of defense response to virus namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai] synonym: "down regulation of antiviral response" EXACT [] synonym: "down-regulation of antiviral response" EXACT [] synonym: "downregulation of antiviral response" EXACT [] synonym: "inhibition of antiviral response" NARROW [] synonym: "negative regulation of antiviral response" EXACT [GOC:dph] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0050688 ! regulation of defense response to virus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051607 ! defense response to virus relationship: negatively_regulates GO:0051607 ! defense response to virus [Term] id: GO:0050688 name: regulation of defense response to virus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai] synonym: "regulation of antiviral response" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051607 ! defense response to virus relationship: regulates GO:0051607 ! defense response to virus [Term] id: GO:0050689 name: negative regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of antiviral response by host" EXACT [] synonym: "down-regulation of antiviral response by host" EXACT [] synonym: "downregulation of antiviral response by host" EXACT [] synonym: "inhibition of antiviral response by host" NARROW [] synonym: "negative regulation by host of antiviral response" EXACT [] synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] is_a: GO:0050687 ! negative regulation of defense response to virus is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0050690 name: regulation of defense response to virus by virus namespace: biological_process def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph] synonym: "regulation by virus of antiviral response" EXACT [] synonym: "regulation of antiviral response by virus" EXACT [GOC:dph] synonym: "viral regulation of antiviral response" EXACT [] is_a: GO:0016032 ! viral process [Term] id: GO:0050691 name: regulation of defense response to virus by host namespace: biological_process def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph] synonym: "host regulation of antiviral response" EXACT [] synonym: "regulation by host of antiviral response" EXACT [] synonym: "regulation of antiviral response by host" RELATED [GOC:dph] is_a: GO:0050688 ! regulation of defense response to virus [Term] id: GO:0050692 name: DNA binding domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein." [PMID:9682036] synonym: "DBD binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050693 name: LBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036] synonym: "ligand binding domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050694 name: galactose 3-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829] synonym: "Gal-3-O-sulfotransferase activity" EXACT [] synonym: "galactose 3-O-sulphotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050695 name: benzoylformate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN] synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7] synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7] synonym: "phenylglyoxylate decarboxylase activity" EXACT [] xref: EC:4.1.1.7 xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN xref: RHEA:23368 xref: UM-BBD_reactionID:r1049 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0050696 name: trichloroethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai] synonym: "trichloroethene catabolic process" EXACT [] synonym: "trichloroethene catabolism" EXACT [] synonym: "trichloroethylene breakdown" EXACT [] synonym: "trichloroethylene catabolism" EXACT [] synonym: "trichloroethylene degradation" EXACT [] is_a: GO:0018979 ! trichloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0050697 name: 1,1,2-trichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271] synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT [] synonym: "TCE-reductive dehalogenase activity" EXACT [] xref: MetaCyc:TCEREDCHLOR-RXN xref: UM-BBD_enzymeID:e0271 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050698 name: proteoglycan sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai] synonym: "proteoglycan sulfate transfer" RELATED [] synonym: "proteoglycan sulphotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050699 name: WW domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050700 name: CARD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050701 name: interleukin-1 secretion namespace: biological_process def: "The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732] synonym: "IL-1 secretion" EXACT [] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032612 ! interleukin-1 production [Term] id: GO:0050702 name: interleukin-1 beta secretion namespace: biological_process def: "The regulated release of interleukin 1 beta from a cell." [GOC:ai] synonym: "IL-1b secretion" EXACT [] is_a: GO:0050701 ! interleukin-1 secretion relationship: part_of GO:0032611 ! interleukin-1 beta production [Term] id: GO:0050703 name: interleukin-1 alpha secretion namespace: biological_process def: "The regulated release of interleukin-1 alpha from a cell." [GOC:ai] synonym: "IL-1a secretion" EXACT [] is_a: GO:0050701 ! interleukin-1 secretion relationship: part_of GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0050704 name: regulation of interleukin-1 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] is_a: GO:0032652 ! regulation of interleukin-1 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050701 ! interleukin-1 secretion relationship: regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050705 name: regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0050704 ! regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050703 ! interleukin-1 alpha secretion relationship: regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050706 name: regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0050704 ! regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050702 ! interleukin-1 beta secretion relationship: regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050707 name: regulation of cytokine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050663 ! cytokine secretion relationship: regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009306 ! protein secretion relationship: regulates GO:0009306 ! protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009306 ! protein secretion relationship: negatively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050710 name: negative regulation of cytokine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai] synonym: "down regulation of cytokine secretion" EXACT [] synonym: "down-regulation of cytokine secretion" EXACT [] synonym: "downregulation of cytokine secretion" EXACT [] synonym: "inhibition of cytokine secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0050707 ! regulation of cytokine secretion is_a: GO:0050709 ! negative regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050663 ! cytokine secretion relationship: negatively_regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050711 name: negative regulation of interleukin-1 secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] synonym: "down regulation of interleukin-1 secretion" EXACT [] synonym: "down-regulation of interleukin-1 secretion" EXACT [] synonym: "downregulation of interleukin-1 secretion" EXACT [] synonym: "inhibition of interleukin-1 secretion" NARROW [] is_a: GO:0032692 ! negative regulation of interleukin-1 production is_a: GO:0050704 ! regulation of interleukin-1 secretion is_a: GO:0050710 ! negative regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050701 ! interleukin-1 secretion relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050712 name: negative regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] synonym: "down regulation of interleukin-1 alpha secretion" EXACT [] synonym: "down-regulation of interleukin-1 alpha secretion" EXACT [] synonym: "downregulation of interleukin-1 alpha secretion" EXACT [] synonym: "inhibition of interleukin-1 alpha secretion" NARROW [] is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion is_a: GO:0050711 ! negative regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050713 name: negative regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] synonym: "down regulation of interleukin-1 beta secretion" EXACT [] synonym: "down-regulation of interleukin-1 beta secretion" EXACT [] synonym: "downregulation of interleukin-1 beta secretion" EXACT [] synonym: "inhibition of interleukin-1 beta secretion" NARROW [] is_a: GO:0032691 ! negative regulation of interleukin-1 beta production is_a: GO:0050706 ! regulation of interleukin-1 beta secretion is_a: GO:0050711 ! negative regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050702 ! interleukin-1 beta secretion relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009306 ! protein secretion relationship: positively_regulates GO:0009306 ! protein secretion [Term] id: GO:0050715 name: positive regulation of cytokine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai] synonym: "activation of cytokine secretion" NARROW [] synonym: "stimulation of cytokine secretion" NARROW [] synonym: "up regulation of cytokine secretion" EXACT [] synonym: "up-regulation of cytokine secretion" EXACT [] synonym: "upregulation of cytokine secretion" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0050707 ! regulation of cytokine secretion is_a: GO:0050714 ! positive regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050663 ! cytokine secretion relationship: positively_regulates GO:0050663 ! cytokine secretion [Term] id: GO:0050716 name: positive regulation of interleukin-1 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] synonym: "activation of interleukin-1 secretion" NARROW [] synonym: "stimulation of interleukin-1 secretion" NARROW [] synonym: "up regulation of interleukin-1 secretion" EXACT [] synonym: "up-regulation of interleukin-1 secretion" EXACT [] synonym: "upregulation of interleukin-1 secretion" EXACT [] is_a: GO:0032732 ! positive regulation of interleukin-1 production is_a: GO:0050704 ! regulation of interleukin-1 secretion is_a: GO:0050715 ! positive regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050701 ! interleukin-1 secretion relationship: positively_regulates GO:0050701 ! interleukin-1 secretion [Term] id: GO:0050717 name: positive regulation of interleukin-1 alpha secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] synonym: "activation of interleukin-1 alpha secretion" NARROW [] synonym: "stimulation of interleukin-1 alpha secretion" NARROW [] synonym: "up regulation of interleukin-1 alpha secretion" EXACT [] synonym: "up-regulation of interleukin-1 alpha secretion" EXACT [] synonym: "upregulation of interleukin-1 alpha secretion" EXACT [] is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion is_a: GO:0050716 ! positive regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050703 ! interleukin-1 alpha secretion relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion [Term] id: GO:0050718 name: positive regulation of interleukin-1 beta secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] synonym: "activation of interleukin-1 beta secretion" NARROW [] synonym: "stimulation of interleukin-1 beta secretion" NARROW [] synonym: "up regulation of interleukin-1 beta secretion" EXACT [] synonym: "up-regulation of interleukin-1 beta secretion" EXACT [] synonym: "upregulation of interleukin-1 beta secretion" EXACT [] is_a: GO:0032731 ! positive regulation of interleukin-1 beta production is_a: GO:0050706 ! regulation of interleukin-1 beta secretion is_a: GO:0050716 ! positive regulation of interleukin-1 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050702 ! interleukin-1 beta secretion relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion [Term] id: GO:0050719 name: interleukin-1 alpha biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "interleukin-1 alpha anabolism" EXACT [] synonym: "interleukin-1 alpha biosynthesis" EXACT [] synonym: "interleukin-1 alpha formation" EXACT [] synonym: "interleukin-1 alpha synthesis" EXACT [] is_a: GO:0042222 ! interleukin-1 biosynthetic process relationship: part_of GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0050720 name: interleukin-1 beta biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "interleukin-1 beta anabolism" EXACT [] synonym: "interleukin-1 beta biosynthesis" EXACT [] synonym: "interleukin-1 beta formation" EXACT [] synonym: "interleukin-1 beta synthesis" EXACT [] is_a: GO:0042222 ! interleukin-1 biosynthetic process relationship: part_of GO:0032611 ! interleukin-1 beta production [Term] id: GO:0050721 name: regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "regulation of interleukin-1 alpha formation" EXACT [] synonym: "regulation of interleukin-1 alpha synthesis" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050722 name: regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "regulation of interleukin-1 beta anabolism" EXACT [] synonym: "regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "regulation of interleukin-1 beta formation" EXACT [] synonym: "regulation of interleukin-1 beta synthesis" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050720 ! interleukin-1 beta biosynthetic process relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050723 name: negative regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 alpha formation" EXACT [] synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT [] is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050724 name: negative regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW [] synonym: "negative regulation of interleukin-1 beta anabolism" EXACT [] synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "negative regulation of interleukin-1 beta formation" EXACT [] synonym: "negative regulation of interleukin-1 beta synthesis" EXACT [] is_a: GO:0032691 ! negative regulation of interleukin-1 beta production is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050725 name: positive regulation of interleukin-1 beta biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] synonym: "activation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 beta anabolism" EXACT [] synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 beta formation" EXACT [] synonym: "positive regulation of interleukin-1 beta synthesis" EXACT [] synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT [] is_a: GO:0032731 ! positive regulation of interleukin-1 beta production is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process [Term] id: GO:0050726 name: positive regulation of interleukin-1 alpha biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT [] synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT [] synonym: "positive regulation of interleukin-1 alpha formation" EXACT [] synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT [] synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW [] synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT [] synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT [] is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process [Term] id: GO:0050727 name: regulation of inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006954 ! inflammatory response relationship: regulates GO:0006954 ! inflammatory response [Term] id: GO:0050728 name: negative regulation of inflammatory response namespace: biological_process alt_id: GO:0030236 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "anti-inflammatory response" EXACT [] synonym: "down regulation of inflammatory response" EXACT [] synonym: "down-regulation of inflammatory response" EXACT [] synonym: "downregulation of inflammatory response" EXACT [] synonym: "inhibition of inflammatory response" NARROW [] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006954 ! inflammatory response relationship: negatively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "activation of inflammatory response" NARROW [] synonym: "stimulation of inflammatory response" NARROW [] synonym: "up regulation of inflammatory response" EXACT [] synonym: "up-regulation of inflammatory response" EXACT [] synonym: "upregulation of inflammatory response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006954 ! inflammatory response relationship: positively_regulates GO:0006954 ! inflammatory response [Term] id: GO:0050730 name: regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050731 name: positive regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050732 name: negative regulation of peptidyl-tyrosine phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation [Term] id: GO:0050733 name: RS domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0050734 name: hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0050735 name: N-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0050736 name: O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0050737 name: O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0050734 ! hydroxycinnamoyltransferase activity [Term] id: GO:0050738 name: fructosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0050739 name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium namespace: biological_process def: "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348] xref: RESID:AA0348 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018211 ! peptidyl-tryptophan modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0050740 name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine namespace: biological_process def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349] xref: RESID:AA0349 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050741 name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine namespace: biological_process def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350] xref: RESID:AA0350 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050742 name: protein-FMN linkage via S-(4a-FMN)-L-cysteine namespace: biological_process def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351] xref: RESID:AA0351 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050743 name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine namespace: biological_process def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352] xref: RESID:AA0352 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050744 name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine namespace: biological_process def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353] xref: RESID:AA0353 is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0050745 name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188] xref: RESID:AA0188 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine [Term] id: GO:0050746 name: regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "regulation of lipoprotein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042157 ! lipoprotein metabolic process relationship: regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050747 name: positive regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "activation of lipoprotein metabolic process" NARROW [] synonym: "positive regulation of lipoprotein metabolism" EXACT [] synonym: "stimulation of lipoprotein metabolic process" NARROW [] synonym: "up regulation of lipoprotein metabolic process" EXACT [] synonym: "up-regulation of lipoprotein metabolic process" EXACT [] synonym: "upregulation of lipoprotein metabolic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042157 ! lipoprotein metabolic process relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050748 name: negative regulation of lipoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] synonym: "down regulation of lipoprotein metabolic process" EXACT [] synonym: "down-regulation of lipoprotein metabolic process" EXACT [] synonym: "downregulation of lipoprotein metabolic process" EXACT [] synonym: "inhibition of lipoprotein metabolic process" NARROW [] synonym: "negative regulation of lipoprotein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042157 ! lipoprotein metabolic process relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process [Term] id: GO:0050749 name: obsolete apolipoprotein E receptor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai] comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). synonym: "apolipoprotein E receptor binding" EXACT [] is_obsolete: true replaced_by: GO:0070326 [Term] id: GO:0050750 name: low-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein receptor." [GOC:ai] synonym: "LDL receptor binding" EXACT [] synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph] is_a: GO:0070325 ! lipoprotein particle receptor binding [Term] id: GO:0050751 name: fractalkine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] synonym: "ABCD-3 biosynthesis" EXACT [] synonym: "ABCD-3 biosynthetic process" EXACT [] synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT [] synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT [] synonym: "CX3CL1 biosynthesis" EXACT [] synonym: "CX3CL1 biosynthetic process" EXACT [] synonym: "fractalkine anabolism" EXACT [] synonym: "fractalkine biosynthesis" EXACT [] synonym: "fractalkine formation" EXACT [] synonym: "fractalkine synthesis" EXACT [] synonym: "neurotactin biosynthesis" EXACT [] synonym: "neurotactin biosynthetic process" EXACT [] is_a: GO:0042033 ! chemokine biosynthetic process is_a: GO:0050756 ! fractalkine metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0032603 ! fractalkine production [Term] id: GO:0050752 name: regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "regulation of CX3CL1 biosynthesis" EXACT [] synonym: "regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "regulation of fractalkine anabolism" EXACT [] synonym: "regulation of fractalkine biosynthesis" EXACT [] synonym: "regulation of fractalkine formation" EXACT [] synonym: "regulation of fractalkine synthesis" EXACT [] synonym: "regulation of neurotactin biosynthesis" EXACT [] synonym: "regulation of neurotactin biosynthetic process" EXACT [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0045073 ! regulation of chemokine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050751 ! fractalkine biosynthetic process relationship: regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050753 name: negative regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "down regulation of fractalkine biosynthetic process" EXACT [] synonym: "down-regulation of fractalkine biosynthetic process" EXACT [] synonym: "downregulation of fractalkine biosynthetic process" EXACT [] synonym: "inhibition of fractalkine biosynthetic process" NARROW [] synonym: "negative regulation of CX3CL1 biosynthesis" EXACT [] synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "negative regulation of fractalkine anabolism" EXACT [] synonym: "negative regulation of fractalkine biosynthesis" EXACT [] synonym: "negative regulation of fractalkine formation" EXACT [] synonym: "negative regulation of fractalkine synthesis" EXACT [] synonym: "negative regulation of neurotactin biosynthesis" EXACT [] synonym: "negative regulation of neurotactin biosynthetic process" EXACT [] is_a: GO:0032684 ! negative regulation of fractalkine production is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process is_a: GO:0050752 ! regulation of fractalkine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050751 ! fractalkine biosynthetic process relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050754 name: positive regulation of fractalkine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] synonym: "activation of fractalkine biosynthetic process" NARROW [] synonym: "positive regulation of CX3CL1 biosynthesis" EXACT [] synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT [] synonym: "positive regulation of fractalkine anabolism" EXACT [] synonym: "positive regulation of fractalkine biosynthesis" EXACT [] synonym: "positive regulation of fractalkine formation" EXACT [] synonym: "positive regulation of fractalkine synthesis" EXACT [] synonym: "positive regulation of neurotactin biosynthesis" EXACT [] synonym: "positive regulation of neurotactin biosynthetic process" EXACT [] synonym: "stimulation of fractalkine biosynthetic process" NARROW [] synonym: "up regulation of fractalkine biosynthetic process" EXACT [] synonym: "up-regulation of fractalkine biosynthetic process" EXACT [] synonym: "upregulation of fractalkine biosynthetic process" EXACT [] is_a: GO:0032724 ! positive regulation of fractalkine production is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process is_a: GO:0050752 ! regulation of fractalkine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050751 ! fractalkine biosynthetic process relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process [Term] id: GO:0050755 name: chemokine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377] synonym: "chemokine metabolism" EXACT [] is_a: GO:0042107 ! cytokine metabolic process [Term] id: GO:0050756 name: fractalkine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] synonym: "ABCD-3 metabolic process" EXACT [] synonym: "ABCD-3 metabolism" EXACT [] synonym: "CX3C membrane-anchored chemokine metabolic process" EXACT [] synonym: "CX3C membrane-anchored chemokine metabolism" EXACT [] synonym: "CX3CL1 metabolic process" EXACT [] synonym: "CX3CL1 metabolism" EXACT [] synonym: "fractalkine metabolism" EXACT [] synonym: "neurotactin metabolic process" EXACT [] synonym: "neurotactin metabolism" EXACT [] is_a: GO:0050755 ! chemokine metabolic process [Term] id: GO:0050757 name: thymidylate synthase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] synonym: "thymidylate synthase anabolism" EXACT [] synonym: "thymidylate synthase biosynthesis" EXACT [] synonym: "thymidylate synthase formation" EXACT [] synonym: "thymidylate synthase synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0050758 name: regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] synonym: "regulation of thymidylate synthase anabolism" EXACT [] synonym: "regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "regulation of thymidylate synthase formation" EXACT [] synonym: "regulation of thymidylate synthase synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050757 ! thymidylate synthase biosynthetic process relationship: regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050759 name: positive regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] synonym: "activation of thymidylate synthase biosynthetic process" NARROW [] synonym: "positive regulation of thymidylate synthase anabolism" EXACT [] synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "positive regulation of thymidylate synthase formation" EXACT [] synonym: "positive regulation of thymidylate synthase synthesis" EXACT [] synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW [] synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process relationship: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050760 name: negative regulation of thymidylate synthase biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT [] synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW [] synonym: "negative regulation of thymidylate synthase anabolism" EXACT [] synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT [] synonym: "negative regulation of thymidylate synthase formation" EXACT [] synonym: "negative regulation of thymidylate synthase synthesis" EXACT [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process relationship: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process [Term] id: GO:0050761 name: depsipeptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] subset: goslim_pir synonym: "depsipeptide metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0050762 name: depsipeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] synonym: "depsipeptide breakdown" EXACT [] synonym: "depsipeptide catabolism" EXACT [] synonym: "depsipeptide degradation" EXACT [] is_a: GO:0043171 ! peptide catabolic process is_a: GO:0050761 ! depsipeptide metabolic process [Term] id: GO:0050763 name: depsipeptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] synonym: "depsipeptide anabolism" EXACT [] synonym: "depsipeptide biosynthesis" EXACT [] synonym: "depsipeptide formation" EXACT [] synonym: "depsipeptide synthesis" EXACT [] is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0050761 ! depsipeptide metabolic process [Term] id: GO:0050764 name: regulation of phagocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006909 ! phagocytosis relationship: regulates GO:0006909 ! phagocytosis [Term] id: GO:0050765 name: negative regulation of phagocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "down regulation of phagocytosis" EXACT [] synonym: "down-regulation of phagocytosis" EXACT [] synonym: "downregulation of phagocytosis" EXACT [] synonym: "inhibition of phagocytosis" NARROW [] is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006909 ! phagocytosis relationship: negatively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0050766 name: positive regulation of phagocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "activation of phagocytosis" NARROW [] synonym: "stimulation of phagocytosis" NARROW [] synonym: "up regulation of phagocytosis" EXACT [] synonym: "up-regulation of phagocytosis" EXACT [] synonym: "upregulation of phagocytosis" EXACT [] is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006909 ! phagocytosis relationship: positively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022008 ! neurogenesis relationship: part_of GO:0048699 ! generation of neurons relationship: regulates GO:0022008 ! neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022008 ! neurogenesis relationship: negatively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022008 ! neurogenesis relationship: positively_regulates GO:0022008 ! neurogenesis [Term] id: GO:0050770 name: regulation of axonogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0010975 ! regulation of neuron projection development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007409 ! axonogenesis relationship: regulates GO:0007409 ! axonogenesis [Term] id: GO:0050771 name: negative regulation of axonogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "down regulation of axonogenesis" EXACT [] synonym: "down-regulation of axonogenesis" EXACT [] synonym: "downregulation of axonogenesis" EXACT [] synonym: "inhibition of axonogenesis" NARROW [] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007409 ! axonogenesis relationship: negatively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050772 name: positive regulation of axonogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "activation of axonogenesis" NARROW [] synonym: "stimulation of axonogenesis" NARROW [] synonym: "up regulation of axonogenesis" EXACT [] synonym: "up-regulation of axonogenesis" EXACT [] synonym: "upregulation of axonogenesis" EXACT [] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007409 ! axonogenesis relationship: positively_regulates GO:0007409 ! axonogenesis [Term] id: GO:0050773 name: regulation of dendrite development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] is_a: GO:0010975 ! regulation of neuron projection development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016358 ! dendrite development relationship: regulates GO:0016358 ! dendrite development [Term] id: GO:0050774 name: negative regulation of dendrite morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "down regulation of dendrite morphogenesis" EXACT [] synonym: "down-regulation of dendrite morphogenesis" EXACT [] synonym: "downregulation of dendrite morphogenesis" EXACT [] synonym: "inhibition of dendrite morphogenesis" NARROW [] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:2000171 ! negative regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048813 ! dendrite morphogenesis relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0050775 name: positive regulation of dendrite morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "activation of dendrite morphogenesis" NARROW [] synonym: "stimulation of dendrite morphogenesis" NARROW [] synonym: "up regulation of dendrite morphogenesis" EXACT [] synonym: "up-regulation of dendrite morphogenesis" EXACT [] synonym: "upregulation of dendrite morphogenesis" EXACT [] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:1900006 ! positive regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048813 ! dendrite morphogenesis relationship: positively_regulates GO:0048813 ! dendrite morphogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006955 ! immune response relationship: regulates GO:0006955 ! immune response [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006955 ! immune response relationship: negatively_regulates GO:0006955 ! immune response [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006955 ! immune response relationship: positively_regulates GO:0006955 ! immune response [Term] id: GO:0050779 name: RNA destabilization namespace: biological_process def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0043487 ! regulation of RNA stability is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0006401 ! RNA catabolic process [Term] id: GO:0050780 name: dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a dopamine receptor." [GOC:ai] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0050781 name: ortho-trichlorophenol reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029] synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT [] synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0050782 name: galactose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" BROAD [] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0050783 name: cocaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732] synonym: "cocaine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0050784 name: cocaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732] synonym: "cocaine breakdown" EXACT [] synonym: "cocaine catabolism" EXACT [] synonym: "cocaine degradation" EXACT [] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0050783 ! cocaine metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0050785 name: advanced glycation end-product receptor activity namespace: molecular_function def: "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)] synonym: "AGE receptor activity" EXACT [PMID:21590515] synonym: "RAGE activity" EXACT [PMID:21590515] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0050786 name: RAGE receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai] synonym: "advanced glycation end-product receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0050787 name: detoxification of mercury ion namespace: biological_process def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:0046689 ! response to mercury ion [Term] id: GO:0050788 name: sequestering of mercury namespace: biological_process def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920] synonym: "mercuric ion (Hg2+) sequestering" EXACT [] synonym: "mercuric ion (Hg2+) sequestration" EXACT [] synonym: "mercury (Hg) ion sequestering" EXACT [] synonym: "mercury (Hg) ion sequestration" EXACT [] synonym: "mercury (Hg2+) ion retention" EXACT [] synonym: "mercury (Hg2+) ion storage" EXACT [] synonym: "retention of mercury (Hg2+) ion" EXACT [] synonym: "sequestering of mercuric ion (Hg2+)" EXACT [] synonym: "sequestering of mercury (Hg) ion" EXACT [] synonym: "sequestration of mercuric ion (Hg2+)" EXACT [] synonym: "sequestration of mercury (Hg) ion" EXACT [] synonym: "storage of mercury (Hg2+) ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0050787 ! detoxification of mercury ion [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] xref: MIPS_funcat:18.02.01 is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050792 name: regulation of viral process namespace: biological_process def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] synonym: "regulation of viral process" BROAD [] synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016032 ! viral process relationship: regulates GO:0016032 ! viral process [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032502 ! developmental process relationship: regulates GO:0032502 ! developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009987 ! cellular process relationship: regulates GO:0009987 ! cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007610 ! behavior relationship: regulates GO:0007610 ! behavior [Term] id: GO:0050796 name: regulation of insulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030073 ! insulin secretion relationship: regulates GO:0030073 ! insulin secretion [Term] id: GO:0050797 name: thymidylate synthase (FAD) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148] synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148] synonym: "FDTS activity" EXACT [EC:2.1.1.148] synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148] synonym: "Thy1 activity" EXACT [] synonym: "ThyX activity" EXACT [] xref: EC:2.1.1.148 xref: KEGG_REACTION:R06613 xref: MetaCyc:RXN-8850 xref: RHEA:29043 is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0050798 name: activated T cell proliferation namespace: biological_process def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph] comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells. synonym: "activated T lymphocyte proliferation" EXACT [] synonym: "activated T-cell proliferation" EXACT [] synonym: "activated T-lymphocyte proliferation" EXACT [] synonym: "proliferation of activated T cells" EXACT [GOC:mah] is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0050799 name: cocaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai] synonym: "cocaine anabolism" EXACT [] synonym: "cocaine biosynthesis" EXACT [] synonym: "cocaine formation" EXACT [] synonym: "cocaine synthesis" EXACT [] is_a: GO:0009710 ! tropane alkaloid biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0050783 ! cocaine metabolic process [Term] id: GO:0050800 name: obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai] comment: This term was made obsolete because it represents both process and function information. synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0006810 [Term] id: GO:0050801 name: ion homeostasis namespace: biological_process alt_id: GO:2000021 def: "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai] synonym: "electrolyte homeostasis" RELATED [] synonym: "negative regulation of crystal formation" RELATED [] synonym: "regulation of ion homeostasis" RELATED [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0050802 name: circadian sleep/wake cycle, sleep namespace: biological_process def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] is_a: GO:0022410 ! circadian sleep/wake cycle process is_a: GO:0030431 ! sleep intersection_of: GO:0030431 ! sleep intersection_of: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0050803 name: regulation of synapse structure or activity namespace: biological_process def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050804 name: modulation of chemical synaptic transmission namespace: biological_process def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] subset: goslim_synapse synonym: "modulation of synaptic transmission" BROAD [] synonym: "regulation of chemical synaptic transmission" EXACT [] synonym: "regulation of synaptic transmission" EXACT [] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007268 ! chemical synaptic transmission relationship: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0050805 name: negative regulation of synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "down regulation of synaptic transmission" EXACT [] synonym: "down-regulation of synaptic transmission" EXACT [] synonym: "downregulation of synaptic transmission" EXACT [] synonym: "inhibition of synaptic transmission" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007268 ! chemical synaptic transmission relationship: negatively_regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0050806 name: positive regulation of synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "activation of synaptic transmission" NARROW [] synonym: "stimulation of synaptic transmission" NARROW [] synonym: "up regulation of synaptic transmission" EXACT [] synonym: "up-regulation of synaptic transmission" EXACT [] synonym: "upregulation of synaptic transmission" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007268 ! chemical synaptic transmission relationship: positively_regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0050807 name: regulation of synapse organization namespace: biological_process def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of synapse organisation" EXACT [GOC:mah] synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of synapse structure" EXACT [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050808 ! synapse organization relationship: part_of GO:0050803 ! regulation of synapse structure or activity relationship: regulates GO:0050808 ! synapse organization [Term] id: GO:0050808 name: synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] subset: goslim_drosophila subset: goslim_synapse synonym: "synapse development" RELATED [GOC:aruk] synonym: "synapse morphogenesis" RELATED [GOC:BHF] synonym: "synapse organisation" EXACT [] synonym: "synapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0050809 name: diazepam binding namespace: molecular_function def: "Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "Valium binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0050810 name: regulation of steroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] synonym: "regulation of steroid anabolism" EXACT [] synonym: "regulation of steroid biosynthesis" EXACT [] synonym: "regulation of steroid formation" EXACT [] synonym: "regulation of steroid synthesis" EXACT [] synonym: "regulation of steroidogenesis" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006694 ! steroid biosynthetic process relationship: regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0050811 name: GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] synonym: "4-aminobutanoate receptor binding" EXACT [] synonym: "4-aminobutyrate receptor binding" EXACT [] synonym: "diazepam binding inhibitor activity" RELATED [] synonym: "gamma-aminobutyric acid receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0050812 name: regulation of acyl-CoA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai] synonym: "regulation of acyl-CoA anabolism" EXACT [] synonym: "regulation of acyl-CoA biosynthesis" EXACT [] synonym: "regulation of acyl-CoA formation" EXACT [] synonym: "regulation of acyl-CoA synthesis" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071616 ! acyl-CoA biosynthetic process relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0050813 name: epothilone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [ISBN:0198506732] synonym: "epothilone metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0033067 ! macrolide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0050814 name: epothilone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai] synonym: "epothilone anabolism" EXACT [] synonym: "epothilone biosynthesis" EXACT [] synonym: "epothilone formation" EXACT [] synonym: "epothilone synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0033068 ! macrolide biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0050813 ! epothilone metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0050815 name: phosphoserine residue binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [GOC:ai] synonym: "phosphoserine binding" RELATED [] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0050816 name: phosphothreonine residue binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein." [GOC:ai] synonym: "phosphothreonine binding" RELATED [] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0050817 name: coagulation namespace: biological_process def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732] subset: goslim_pir synonym: "clotting" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050818 name: regulation of coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] synonym: "regulation of clotting" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050817 ! coagulation relationship: regulates GO:0050817 ! coagulation [Term] id: GO:0050819 name: negative regulation of coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai] synonym: "anticoagulant activity" RELATED [] synonym: "down regulation of coagulation" EXACT [] synonym: "down-regulation of coagulation" EXACT [] synonym: "downregulation of coagulation" EXACT [] synonym: "inhibition of coagulation" NARROW [] synonym: "negative regulation of clotting." EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050817 ! coagulation relationship: negatively_regulates GO:0050817 ! coagulation [Term] id: GO:0050820 name: positive regulation of coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] synonym: "activation of coagulation" NARROW [] synonym: "positive regulation of clotting" EXACT [] synonym: "stimulation of coagulation" NARROW [] synonym: "up regulation of coagulation" EXACT [] synonym: "up-regulation of coagulation" EXACT [] synonym: "upregulation of coagulation" EXACT [] is_a: GO:0050818 ! regulation of coagulation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050817 ! coagulation relationship: positively_regulates GO:0050817 ! coagulation [Term] id: GO:0050821 name: protein stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] subset: goslim_chembl synonym: "lysosomal protein stabilization" NARROW [] synonym: "positive regulation of protein stability" EXACT [] synonym: "protein sequestering" RELATED [] synonym: "protein stabilisation" EXACT [GOC:ah] synonym: "protein stabilization activity" RELATED [] xref: MIPS_funcat:14.01 is_a: GO:0031647 ! regulation of protein stability [Term] id: GO:0050822 name: peptide stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai] synonym: "peptide stabilisation" EXACT [GOC:ah] synonym: "peptide stabilization activity" RELATED [] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0050823 name: peptide antigen stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai] synonym: "peptide antigen stabilization activity" RELATED [] is_a: GO:0050822 ! peptide stabilization relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0050824 name: obsolete water binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with water (H2O)." [GOC:ai] comment: This term was obsoleted because water binding is non-specific. is_obsolete: true [Term] id: GO:0050825 name: ice binding namespace: molecular_function def: "Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators] synonym: "antifreeze activity" RELATED [] synonym: "ice crystal binding" EXACT [] synonym: "ice nucleation activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0050826 name: response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl] synonym: "antifreeze activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0009409 ! response to cold [Term] id: GO:0050828 name: regulation of liquid surface tension namespace: biological_process def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732] synonym: "regulation of surface tension of a liquid" EXACT [] synonym: "surfactant activity" RELATED [] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0050829 name: defense response to Gram-negative bacterium namespace: biological_process def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] synonym: "defence response to Gram-negative bacteria" EXACT [] synonym: "defence response to Gram-negative bacterium" EXACT [] synonym: "defense response to Gram-negative bacteria" EXACT [] synonym: "Gram-negative antibacterial peptide activity" RELATED [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050830 name: defense response to Gram-positive bacterium namespace: biological_process def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] synonym: "defence response to Gram-positive bacteria" EXACT [] synonym: "defence response to Gram-positive bacterium" EXACT [] synonym: "defense response to Gram-positive bacteria" EXACT [] synonym: "Gram-positive antibacterial peptide activity" RELATED [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050831 name: male-specific defense response to bacterium namespace: biological_process def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai] synonym: "male-specific antibacterial peptide activity" RELATED [] synonym: "male-specific defence response to bacteria" EXACT [] synonym: "male-specific defence response to bacterium" EXACT [] synonym: "male-specific defense response to bacteria" EXACT [] is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0050832 name: defense response to fungus namespace: biological_process alt_id: GO:0009623 alt_id: GO:0042831 def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] synonym: "defence response to fungi" EXACT [] synonym: "defence response to fungus" EXACT [] synonym: "defense response to fungi" EXACT [] synonym: "response to parasitic fungi" NARROW [] synonym: "response to parasitic fungus" NARROW [] is_a: GO:0009620 ! response to fungus is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0050833 name: pyruvate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] xref: Reactome:R-HSA-372342 "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:1901475 ! pyruvate transmembrane transport [Term] id: GO:0050834 name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] xref: RESID:AA0355 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0050835 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356] xref: RESID:AA0356 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0050843 ! S-adenosylmethionine catabolic process [Term] id: GO:0050836 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357] xref: RESID:AA0357 is_a: GO:0018195 ! peptidyl-arginine modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0050837 name: peptide cross-linking via L-cysteinyl-L-selenocysteine namespace: biological_process def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358] xref: RESID:AA0358 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0050838 name: peptidyl-5-hydroxy-L-lysine trimethylation namespace: biological_process def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] xref: RESID:AA0359 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0050839 name: cell adhesion molecule binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai] synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "CAM binding" EXACT [] synonym: "cell adhesion molecule activity" RELATED [] synonym: "cell adhesion receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai] subset: goslim_chembl subset: goslim_pir synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0050841 name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT [] synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT [] xref: RESID:AA0359 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0050842 name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide namespace: biological_process def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] xref: RESID:AA0355 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster [Term] id: GO:0050843 name: S-adenosylmethionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine catabolic process" EXACT [] synonym: "S-adenosyl methionine catabolism" EXACT [] synonym: "S-adenosylmethionine breakdown" EXACT [] synonym: "S-adenosylmethionine catabolism" EXACT [] synonym: "S-adenosylmethionine degradation" EXACT [] synonym: "SAM catabolic process" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0050844 name: peptidyl-selenocysteine modification namespace: biological_process def: "The modification of peptidyl-selenocysteine." [GOC:ai] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0050845 name: teichuronic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] synonym: "teichuronic acid anabolism" EXACT [] synonym: "teichuronic acid biosynthesis" EXACT [] synonym: "teichuronic acid formation" EXACT [] synonym: "teichuronic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0050846 ! teichuronic acid metabolic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0050846 name: teichuronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] synonym: "teichuronic acid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process [Term] id: GO:0050847 name: progesterone receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870] synonym: "progesterone receptor signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0050848 name: regulation of calcium-mediated signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] synonym: "regulation of calcium-mediated signalling" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019722 ! calcium-mediated signaling relationship: regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050849 name: negative regulation of calcium-mediated signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592] synonym: "down regulation of calcium-mediated signaling" EXACT [] synonym: "down-regulation of calcium-mediated signaling" EXACT [] synonym: "downregulation of calcium-mediated signaling" EXACT [] synonym: "inhibition of calcium-mediated signaling" NARROW [] synonym: "negative regulation of calcium-mediated signalling" EXACT [] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019722 ! calcium-mediated signaling relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050850 name: positive regulation of calcium-mediated signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] synonym: "activation of calcium-mediated signaling" NARROW [] synonym: "positive regulation of calcium-mediated signalling" EXACT [] synonym: "stimulation of calcium-mediated signaling" NARROW [] synonym: "up regulation of calcium-mediated signaling" EXACT [] synonym: "up-regulation of calcium-mediated signaling" EXACT [] synonym: "upregulation of calcium-mediated signaling" EXACT [] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019722 ! calcium-mediated signaling relationship: positively_regulates GO:0019722 ! calcium-mediated signaling [Term] id: GO:0050851 name: antigen receptor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add] synonym: "antigen receptor-mediated signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0050852 name: T cell receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add] synonym: "T lymphocyte receptor signaling pathway" EXACT [] synonym: "T lymphocyte receptor signalling pathway" EXACT [] synonym: "T-cell receptor signaling pathway" EXACT [] synonym: "T-cell receptor signalling pathway" EXACT [] synonym: "T-lymphocyte receptor signaling pathway" EXACT [] synonym: "T-lymphocyte receptor signalling pathway" EXACT [] synonym: "TCR signaling pathway" EXACT [] is_a: GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050853 name: B cell receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add] synonym: "B cell receptor signalling pathway" EXACT [] synonym: "B lymphocyte receptor signaling pathway" EXACT [] synonym: "B lymphocyte receptor signalling pathway" EXACT [] synonym: "B-cell receptor signaling pathway" EXACT [] synonym: "B-cell receptor signalling pathway" EXACT [] synonym: "B-lymphocyte receptor signaling pathway" EXACT [] synonym: "B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050854 name: regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "regulation of antigen receptor mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050851 ! antigen receptor-mediated signaling pathway relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050855 name: regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "regulation of B cell receptor signalling pathway" EXACT [] synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of B-cell receptor signaling pathway" EXACT [] synonym: "regulation of B-cell receptor signalling pathway" EXACT [] synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050853 ! B cell receptor signaling pathway relationship: regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050856 name: regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of T-cell receptor signaling pathway" EXACT [] synonym: "regulation of T-cell receptor signalling pathway" EXACT [] synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "regulation of TCR signaling pathway" EXACT [] is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050852 ! T cell receptor signaling pathway relationship: regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050857 name: positive regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "activation of antigen receptor-mediated signaling pathway" NARROW [] synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT [] synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW [] synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0050778 ! positive regulation of immune response is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050858 name: negative regulation of antigen receptor-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT [] synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW [] synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway [Term] id: GO:0050859 name: negative regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "down regulation of B cell receptor signaling pathway" EXACT [] synonym: "down-regulation of B cell receptor signaling pathway" EXACT [] synonym: "downregulation of B cell receptor signaling pathway" EXACT [] synonym: "inhibition of B cell receptor signaling pathway" NARROW [] synonym: "negative regulation of B cell receptor signalling pathway" EXACT [] synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of B-cell receptor signaling pathway" EXACT [] synonym: "negative regulation of B-cell receptor signalling pathway" EXACT [] synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT [] is_a: GO:0050855 ! regulation of B cell receptor signaling pathway is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050853 ! B cell receptor signaling pathway relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050860 name: negative regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "down regulation of T cell receptor signaling pathway" EXACT [] synonym: "down-regulation of T cell receptor signaling pathway" EXACT [] synonym: "downregulation of T cell receptor signaling pathway" EXACT [] synonym: "inhibition of T cell receptor signaling pathway" NARROW [] synonym: "negative regulation of T cell receptor signalling pathway" EXACT [] synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of T-cell receptor signaling pathway" EXACT [] synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "negative regulation of TCR signaling pathway" EXACT [] is_a: GO:0050856 ! regulation of T cell receptor signaling pathway is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050852 ! T cell receptor signaling pathway relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050861 name: positive regulation of B cell receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] synonym: "activation of B cell receptor signaling pathway" NARROW [] synonym: "positive regulation of B cell receptor signalling pathway" EXACT [] synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of B-cell receptor signaling pathway" EXACT [] synonym: "positive regulation of B-cell receptor signalling pathway" EXACT [] synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT [] synonym: "stimulation of B cell receptor signaling pathway" NARROW [] synonym: "up regulation of B cell receptor signaling pathway" EXACT [] synonym: "up-regulation of B cell receptor signaling pathway" EXACT [] synonym: "upregulation of B cell receptor signaling pathway" EXACT [] is_a: GO:0050855 ! regulation of B cell receptor signaling pathway is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050853 ! B cell receptor signaling pathway relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway [Term] id: GO:0050862 name: positive regulation of T cell receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] synonym: "activation of T cell receptor signaling pathway" NARROW [] synonym: "positive regulation of T cell receptor signalling pathway" EXACT [] synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of T-cell receptor signaling pathway" EXACT [] synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT [] synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT [] synonym: "positive regulation of TCR signaling pathway" EXACT [] synonym: "stimulation of T cell receptor signaling pathway" NARROW [] synonym: "up regulation of T cell receptor signaling pathway" EXACT [] synonym: "up-regulation of T cell receptor signaling pathway" EXACT [] synonym: "upregulation of T cell receptor signaling pathway" EXACT [] is_a: GO:0050856 ! regulation of T cell receptor signaling pathway is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050852 ! T cell receptor signaling pathway relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0050863 name: regulation of T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "regulation of T lymphocyte activation" EXACT [] synonym: "regulation of T-cell activation" EXACT [] synonym: "regulation of T-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042110 ! T cell activation relationship: regulates GO:0042110 ! T cell activation [Term] id: GO:0050864 name: regulation of B cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "regulation of B lymphocyte activation" EXACT [] synonym: "regulation of B-cell activation" EXACT [] synonym: "regulation of B-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042113 ! B cell activation relationship: regulates GO:0042113 ! B cell activation [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001775 ! cell activation relationship: regulates GO:0001775 ! cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001775 ! cell activation relationship: negatively_regulates GO:0001775 ! cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001775 ! cell activation relationship: positively_regulates GO:0001775 ! cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "down regulation of T cell activation" EXACT [] synonym: "down-regulation of T cell activation" EXACT [] synonym: "downregulation of T cell activation" EXACT [] synonym: "inhibition of T cell activation" NARROW [] synonym: "negative regulation of T lymphocyte activation" EXACT [] synonym: "negative regulation of T-cell activation" EXACT [] synonym: "negative regulation of T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042110 ! T cell activation relationship: negatively_regulates GO:0042110 ! T cell activation [Term] id: GO:0050869 name: negative regulation of B cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "down regulation of B cell activation" EXACT [] synonym: "down-regulation of B cell activation" EXACT [] synonym: "downregulation of B cell activation" EXACT [] synonym: "inhibition of B cell activation" NARROW [] synonym: "negative regulation of B lymphocyte activation" EXACT [] synonym: "negative regulation of B-cell activation" EXACT [] synonym: "negative regulation of B-lymphocyte activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042113 ! B cell activation relationship: negatively_regulates GO:0042113 ! B cell activation [Term] id: GO:0050870 name: positive regulation of T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "activation of T cell activation" NARROW [] synonym: "positive regulation of T lymphocyte activation" EXACT [] synonym: "positive regulation of T-cell activation" EXACT [] synonym: "positive regulation of T-lymphocyte activation" EXACT [] synonym: "stimulation of T cell activation" NARROW [] synonym: "up regulation of T cell activation" EXACT [] synonym: "up-regulation of T cell activation" EXACT [] synonym: "upregulation of T cell activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042110 ! T cell activation relationship: positively_regulates GO:0042110 ! T cell activation [Term] id: GO:0050871 name: positive regulation of B cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai] synonym: "activation of B cell activation" NARROW [] synonym: "positive regulation of B lymphocyte activation" EXACT [] synonym: "positive regulation of B-cell activation" EXACT [] synonym: "positive regulation of B-lymphocyte activation" EXACT [] synonym: "stimulation of B cell activation" NARROW [] synonym: "up regulation of B cell activation" EXACT [] synonym: "up-regulation of B cell activation" EXACT [] synonym: "upregulation of B cell activation" EXACT [] is_a: GO:0050864 ! regulation of B cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042113 ! B cell activation relationship: positively_regulates GO:0042113 ! B cell activation [Term] id: GO:0050872 name: white fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945] synonym: "white adipocyte cell differentiation" EXACT [] synonym: "white adipocyte differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation [Term] id: GO:0050873 name: brown fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810] synonym: "brown adipocyte cell differentiation" EXACT [] synonym: "brown adipocyte differentiation" EXACT [] is_a: GO:0045444 ! fat cell differentiation [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] comment: Discussion of class label and synonyms: https://github.com/geneontology/go-ontology/issues/13824 subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] xref: MIPS_funcat:36.25.03 is_a: GO:0003008 ! system process [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050879 name: multicellular organismal movement namespace: biological_process def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] subset: goslim_pir xref: MIPS_funcat:02.45.11 is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050881 name: musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0050882 name: voluntary musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph] is_a: GO:0050881 ! musculoskeletal movement [Term] id: GO:0050883 name: musculoskeletal movement, spinal reflex action namespace: biological_process def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph] is_a: GO:0050881 ! musculoskeletal movement is_a: GO:0060004 ! reflex [Term] id: GO:0050884 name: neuromuscular process controlling posture namespace: biological_process def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb] synonym: "regulation of posture" EXACT [] xref: MIPS_funcat:36.25.03.03.03 is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050885 name: neuromuscular process controlling balance namespace: biological_process def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph] synonym: "regulation of balance" RELATED [] xref: MIPS_funcat:36.25.03.03.03 is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050886 name: endocrine process namespace: biological_process def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544] subset: goslim_pir synonym: "endocrine physiological process" EXACT [] synonym: "endocrine physiology" EXACT [] is_a: GO:0003008 ! system process [Term] id: GO:0050887 name: determination of sensory modality namespace: biological_process def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050888 name: determination of stimulus location namespace: biological_process def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050889 name: determination of stimulus intensity namespace: biological_process def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] subset: goslim_drosophila xref: Wikipedia:Cognition is_a: GO:0050877 ! nervous system process [Term] id: GO:0050891 name: multicellular organismal water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb] synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0030104 ! water homeostasis is_a: GO:0048871 ! multicellular organismal homeostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0050892 name: intestinal absorption namespace: biological_process def: "Any process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph] is_a: GO:0006810 ! transport is_a: GO:0022600 ! digestive system process [Term] id: GO:0050893 name: sensory processing namespace: biological_process def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544] is_a: GO:0050890 ! cognition relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050894 name: determination of affect namespace: biological_process def: "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544] is_a: GO:0050893 ! sensory processing [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "physiological response to stimulus" EXACT [] xref: MIPS_funcat:34.11 is_a: GO:0008150 ! biological_process [Term] id: GO:0050897 name: cobalt ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai] synonym: "cobalt binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0050898 name: nitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [PMID:18987211] synonym: "nitrile metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0050899 name: nitrile catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544] synonym: "nitrile breakdown" EXACT [] synonym: "nitrile catabolism" EXACT [] synonym: "nitrile degradation" EXACT [] xref: MIPS_funcat:01.02.01.09.08 is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0050898 ! nitrile metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0050900 name: leukocyte migration namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration" EXACT [] synonym: "immune cell trafficking" EXACT [] synonym: "leucocyte migration" EXACT [] synonym: "leucocyte trafficking" EXACT [] synonym: "leukocyte trafficking" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration [Term] id: GO:0050901 name: leukocyte tethering or rolling namespace: biological_process def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)." [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation] is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050902 name: leukocyte adhesive activation namespace: biological_process def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "leukocyte adhesive triggering" EXACT [] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050903 name: leukocyte activation-dependent arrest namespace: biological_process def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050904 name: diapedesis namespace: biological_process def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0045123 ! cellular extravasation [Term] id: GO:0050905 name: neuromuscular process namespace: biological_process def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] synonym: "neuromotor process" EXACT [] synonym: "neuromuscular physiological process" EXACT [] xref: MIPS_funcat:36.25.03.03 is_a: GO:0050877 ! nervous system process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007600 ! sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007601 ! visual perception relationship: part_of GO:0007601 ! visual perception [Term] id: GO:0050909 name: sensory perception of taste namespace: biological_process def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai] synonym: "gustation" EXACT [] synonym: "sense of taste" EXACT [] synonym: "taste" EXACT [] synonym: "taste perception" EXACT [] xref: MIPS_funcat:36.25.01.11 xref: Wikipedia:Taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050910 name: detection of mechanical stimulus involved in sensory perception of sound namespace: biological_process alt_id: GO:0009592 alt_id: GO:0055128 def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai] synonym: "detection of sound" EXACT [] synonym: "hearing, sensory transduction of sound" EXACT [] synonym: "perception of sound, detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT [] synonym: "sensory transduction of sound" EXACT [] is_a: GO:0050877 ! nervous system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0007605 ! sensory perception of sound relationship: part_of GO:0007605 ! sensory perception of sound [Term] id: GO:0050911 name: detection of chemical stimulus involved in sensory perception of smell namespace: biological_process def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "perception of smell, detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory detection of chemical stimulus" EXACT [] synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of smell" EXACT [] synonym: "sensory detection of scent" EXACT [] synonym: "sensory detection of smell" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT [] synonym: "sensory transduction of scent" EXACT [] synonym: "sensory transduction of smell" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0007608 ! sensory perception of smell relationship: part_of GO:0007608 ! sensory perception of smell [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste namespace: biological_process def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "perception of taste, detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] synonym: "sensory detection of taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] synonym: "sensory transduction of taste" EXACT [] synonym: "taste perception" BROAD [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050909 ! sensory perception of taste relationship: part_of GO:0050909 ! sensory perception of taste [Term] id: GO:0050913 name: sensory perception of bitter taste namespace: biological_process def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "bitter taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050914 name: sensory perception of salty taste namespace: biological_process def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "salty taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050915 name: sensory perception of sour taste namespace: biological_process def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sour taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050916 name: sensory perception of sweet taste namespace: biological_process def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sweet taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050917 name: sensory perception of umami taste namespace: biological_process def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai] synonym: "umami taste perception" EXACT [] is_a: GO:0050909 ! sensory perception of taste [Term] id: GO:0050918 name: positive chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] synonym: "chemoattraction" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0050919 name: negative chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] synonym: "chemoaversion" EXACT [] synonym: "chemorepulsion" EXACT [] is_a: GO:0006935 ! chemotaxis [Term] id: GO:0050920 name: regulation of chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006935 ! chemotaxis relationship: regulates GO:0006935 ! chemotaxis [Term] id: GO:0050921 name: positive regulation of chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "activation of chemotaxis" NARROW [] synonym: "stimulation of chemotaxis" NARROW [] synonym: "up regulation of chemotaxis" EXACT [] synonym: "up-regulation of chemotaxis" EXACT [] synonym: "upregulation of chemotaxis" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006935 ! chemotaxis relationship: positively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0050922 name: negative regulation of chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "down regulation of chemotaxis" EXACT [] synonym: "down-regulation of chemotaxis" EXACT [] synonym: "downregulation of chemotaxis" EXACT [] synonym: "inhibition of chemotaxis" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006935 ! chemotaxis relationship: negatively_regulates GO:0006935 ! chemotaxis [Term] id: GO:0050923 name: regulation of negative chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050919 ! negative chemotaxis relationship: regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050924 name: positive regulation of negative chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "activation of negative chemotaxis" NARROW [] synonym: "stimulation of negative chemotaxis" NARROW [] synonym: "up regulation of negative chemotaxis" EXACT [] synonym: "up-regulation of negative chemotaxis" EXACT [] synonym: "upregulation of negative chemotaxis" EXACT [] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0050923 ! regulation of negative chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050919 ! negative chemotaxis relationship: positively_regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050925 name: negative regulation of negative chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "down regulation of negative chemotaxis" EXACT [] synonym: "down-regulation of negative chemotaxis" EXACT [] synonym: "downregulation of negative chemotaxis" EXACT [] synonym: "inhibition of negative chemotaxis" NARROW [] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0050923 ! regulation of negative chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050919 ! negative chemotaxis relationship: negatively_regulates GO:0050919 ! negative chemotaxis [Term] id: GO:0050926 name: regulation of positive chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050918 ! positive chemotaxis relationship: regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050927 name: positive regulation of positive chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "activation of positive chemotaxis" NARROW [] synonym: "stimulation of positive chemotaxis" NARROW [] synonym: "up regulation of positive chemotaxis" EXACT [] synonym: "up-regulation of positive chemotaxis" EXACT [] synonym: "upregulation of positive chemotaxis" EXACT [] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0050926 ! regulation of positive chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050918 ! positive chemotaxis relationship: positively_regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050928 name: negative regulation of positive chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] synonym: "down regulation of positive chemotaxis" EXACT [] synonym: "down-regulation of positive chemotaxis" EXACT [] synonym: "downregulation of positive chemotaxis" EXACT [] synonym: "inhibition of positive chemotaxis" NARROW [] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0050926 ! regulation of positive chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050918 ! positive chemotaxis relationship: negatively_regulates GO:0050918 ! positive chemotaxis [Term] id: GO:0050929 name: induction of negative chemotaxis namespace: biological_process def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050924 ! positive regulation of negative chemotaxis [Term] id: GO:0050930 name: induction of positive chemotaxis namespace: biological_process def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] is_a: GO:0050927 ! positive regulation of positive chemotaxis [Term] id: GO:0050931 name: pigment cell differentiation namespace: biological_process alt_id: GO:0043357 alt_id: GO:0043358 def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. synonym: "chromatophore differentiation" EXACT [] synonym: "pigmented cell differentiation" EXACT [] xref: MIPS_funcat:43.03.03 is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0050932 name: regulation of pigment cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048070 ! regulation of developmental pigmentation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050931 ! pigment cell differentiation relationship: regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050933 name: early stripe melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836] synonym: "early stripe melanocyte cell differentiation" EXACT [] synonym: "early stripe melanophore differentiation" EXACT [] is_a: GO:0030318 ! melanocyte differentiation [Term] id: GO:0050934 name: late stripe melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836] synonym: "late stripe melanocyte cell differentiation" EXACT [] synonym: "late stripe melanophore differentiation" EXACT [] is_a: GO:0030318 ! melanocyte differentiation [Term] id: GO:0050935 name: iridophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836] synonym: "iridophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0050936 name: xanthophore differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "xanthophore cell differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0050937 name: regulation of iridophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai] is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050935 ! iridophore differentiation relationship: regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050938 name: regulation of xanthophore differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050936 ! xanthophore differentiation relationship: regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050939 name: regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "regulation of early stripe melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050933 ! early stripe melanocyte differentiation relationship: regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050940 name: regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "regulation of late stripe melanophore differentiation" EXACT [] is_a: GO:0045634 ! regulation of melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050934 ! late stripe melanocyte differentiation relationship: regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050941 name: negative regulation of pigment cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "down regulation of pigment cell differentiation" EXACT [] synonym: "down-regulation of pigment cell differentiation" EXACT [] synonym: "downregulation of pigment cell differentiation" EXACT [] synonym: "inhibition of pigment cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050931 ! pigment cell differentiation relationship: negatively_regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050942 name: positive regulation of pigment cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "activation of pigment cell differentiation" NARROW [] synonym: "stimulation of pigment cell differentiation" NARROW [] synonym: "up regulation of pigment cell differentiation" EXACT [] synonym: "up-regulation of pigment cell differentiation" EXACT [] synonym: "upregulation of pigment cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050931 ! pigment cell differentiation relationship: positively_regulates GO:0050931 ! pigment cell differentiation [Term] id: GO:0050943 name: negative regulation of iridophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "down regulation of iridophore differentiation" EXACT [] synonym: "down-regulation of iridophore differentiation" EXACT [] synonym: "downregulation of iridophore differentiation" EXACT [] synonym: "inhibition of iridophore differentiation" NARROW [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050935 ! iridophore differentiation relationship: negatively_regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050944 name: negative regulation of xanthophore differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "down regulation of xanthophore differentiation" EXACT [] synonym: "down-regulation of xanthophore differentiation" EXACT [] synonym: "downregulation of xanthophore differentiation" EXACT [] synonym: "inhibition of xanthophore differentiation" NARROW [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050941 ! negative regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050936 ! xanthophore differentiation relationship: negatively_regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050945 name: positive regulation of iridophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai] synonym: "activation of iridophore differentiation" NARROW [] synonym: "stimulation of iridophore differentiation" NARROW [] synonym: "up regulation of iridophore differentiation" EXACT [] synonym: "up-regulation of iridophore differentiation" EXACT [] synonym: "upregulation of iridophore differentiation" EXACT [] is_a: GO:0050937 ! regulation of iridophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050935 ! iridophore differentiation relationship: positively_regulates GO:0050935 ! iridophore differentiation [Term] id: GO:0050946 name: positive regulation of xanthophore differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai] comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. synonym: "activation of xanthophore differentiation" NARROW [] synonym: "stimulation of xanthophore differentiation" NARROW [] synonym: "up regulation of xanthophore differentiation" EXACT [] synonym: "up-regulation of xanthophore differentiation" EXACT [] synonym: "upregulation of xanthophore differentiation" EXACT [] is_a: GO:0050938 ! regulation of xanthophore differentiation is_a: GO:0050942 ! positive regulation of pigment cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050936 ! xanthophore differentiation relationship: positively_regulates GO:0050936 ! xanthophore differentiation [Term] id: GO:0050947 name: negative regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "down regulation of early stripe melanocyte differentiation" EXACT [] synonym: "down-regulation of early stripe melanocyte differentiation" EXACT [] synonym: "downregulation of early stripe melanocyte differentiation" EXACT [] synonym: "inhibition of early stripe melanocyte differentiation" NARROW [] synonym: "negative regulation of early stripe melanophore differentiation" EXACT [] is_a: GO:0045635 ! negative regulation of melanocyte differentiation is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050948 name: positive regulation of early stripe melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] synonym: "activation of early stripe melanocyte differentiation" NARROW [] synonym: "positive regulation of early stripe melanophore differentiation" EXACT [] synonym: "stimulation of early stripe melanocyte differentiation" NARROW [] synonym: "up regulation of early stripe melanocyte differentiation" EXACT [] synonym: "up-regulation of early stripe melanocyte differentiation" EXACT [] synonym: "upregulation of early stripe melanocyte differentiation" EXACT [] is_a: GO:0045636 ! positive regulation of melanocyte differentiation is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050933 ! early stripe melanocyte differentiation relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation [Term] id: GO:0050949 name: negative regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "down regulation of late stripe melanocyte differentiation" EXACT [] synonym: "down-regulation of late stripe melanocyte differentiation" EXACT [] synonym: "downregulation of late stripe melanocyte differentiation" EXACT [] synonym: "inhibition of late stripe melanocyte differentiation" NARROW [] synonym: "negative regulation of late stripe melanophore differentiation" EXACT [] is_a: GO:0045635 ! negative regulation of melanocyte differentiation is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050950 name: positive regulation of late stripe melanocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] synonym: "activation of late stripe melanocyte differentiation" NARROW [] synonym: "positive regulation of late stripe melanophore differentiation" EXACT [] synonym: "stimulation of late stripe melanocyte differentiation" NARROW [] synonym: "up regulation of late stripe melanocyte differentiation" EXACT [] synonym: "up-regulation of late stripe melanocyte differentiation" EXACT [] synonym: "upregulation of late stripe melanocyte differentiation" EXACT [] is_a: GO:0045636 ! positive regulation of melanocyte differentiation is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050934 ! late stripe melanocyte differentiation relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation [Term] id: GO:0050951 name: sensory perception of temperature stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "sensory perception of thermal stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050952 name: sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050955 name: thermoception namespace: biological_process def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception] synonym: "thermoreception" EXACT [] xref: Wikipedia:Thermoception is_a: GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050956 name: electroception namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception] synonym: "electroception sense" EXACT [] synonym: "electroceptive sense" EXACT [] xref: Wikipedia:Electroreception is_a: GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050957 name: equilibrioception namespace: biological_process def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com] synonym: "sensory perception of orientation with respect to gravity" EXACT [] xref: MIPS_funcat:36.25.01.07 xref: Wikipedia:Equilibrioception is_a: GO:0007600 ! sensory perception relationship: part_of GO:0050885 ! neuromuscular process controlling balance [Term] id: GO:0050958 name: magnetoreception namespace: biological_process def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] synonym: "magnetoception" EXACT [] synonym: "sensory perception of magnetic field" EXACT [] xref: MIPS_funcat:34.11.08 xref: Wikipedia:Magnetoception is_a: GO:0007600 ! sensory perception [Term] id: GO:0050959 name: echolocation namespace: biological_process def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [PMID:16005275, Wikipedia:Animal_echolocation] synonym: "perception of environment using reflected sound waves" EXACT [] xref: Wikipedia:Echolocation is_a: GO:0050877 ! nervous system process [Term] id: GO:0050960 name: detection of temperature stimulus involved in thermoception namespace: biological_process def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos] synonym: "sensory detection of temperature stimulus during thermoception" EXACT [] synonym: "sensory detection of thermal stimulus during thermoception" EXACT [] synonym: "sensory transduction of temperature stimulus during thermoception" EXACT [] synonym: "sensory transduction of thermal stimulus during thermoception" EXACT [] synonym: "thermoception, sensory detection of temperature stimulus" EXACT [] synonym: "thermoception, sensory detection of thermal stimulus" EXACT [] synonym: "thermoception, sensory transduction of temperature stimulus" EXACT [] synonym: "thermoception, sensory transduction of thermal stimulus" EXACT [] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: part_of GO:0050955 ! thermoception relationship: part_of GO:0050955 ! thermoception [Term] id: GO:0050961 name: detection of temperature stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of heat stimulus during sensory perception" NARROW [] synonym: "sensory detection of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during sensory perception" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of heat stimulus" NARROW [] synonym: "sensory perception, sensory detection of temperature stimulus" EXACT [] synonym: "sensory perception, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception, sensory transduction of heat stimulus" NARROW [] synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of heat stimulus during sensory perception" NARROW [] synonym: "sensory transduction of temperature stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT [] is_a: GO:0016048 ! detection of temperature stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050951 ! sensory perception of temperature stimulus [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0050963 name: detection of electrical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus" EXACT [] synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050981 ! detection of electrical stimulus intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050952 ! sensory perception of electrical stimulus [Term] id: GO:0050964 name: detection of electrical stimulus involved in electroception namespace: biological_process def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb] synonym: "electroception, detection of electrical stimulus" EXACT [] synonym: "electroception, sensory detection of electrical stimulus" EXACT [] synonym: "electroception, sensory transduction" EXACT [] synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during electroception" RELATED [] synonym: "sensory transduction of electrical stimulus during electroception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0050956 ! electroception relationship: part_of GO:0050956 ! electroception [Term] id: GO:0050965 name: detection of temperature stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "perception of pain, detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory detection of temperature stimulus" EXACT [] synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT [] synonym: "sensory detection of temperature stimulus during perception of pain" EXACT [] synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT [] synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT [] synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT [] synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT [] synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT [] synonym: "thermal nociception" RELATED [GOC:pr] is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0016048 ! detection of temperature stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050966 name: detection of mechanical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "mechanical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050967 name: detection of electrical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb] synonym: "perception of pain, detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during perception of pain" RELATED [] synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050968 name: detection of chemical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "chemical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain [Term] id: GO:0050969 name: detection of chemical stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai, GOC:dos] synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT [] synonym: "magnetoreception, detection of chemical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: part_of GO:0050958 ! magnetoreception relationship: part_of GO:0050977 ! magnetoreception by sensory perception of chemical stimulus [Term] id: GO:0050970 name: detection of electrical stimulus involved in magnetoreception namespace: biological_process def: "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception] synonym: "detection of electrical stimulus during magnetoreception" RELATED [GOC:dph, GOC:tb] synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT [] synonym: "magnetoreception, detection of electrical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT [] synonym: "sensory detection of electrical stimulus during magnetoreception" RELATED [] synonym: "sensory transduction of electrical stimulus during magnetoreception" RELATED [] is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception intersection_of: GO:0050981 ! detection of electrical stimulus intersection_of: part_of GO:0050958 ! magnetoreception relationship: part_of GO:0050978 ! magnetoreception by sensory perception of electrical stimulus [Term] id: GO:0050971 name: detection of mechanical stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai, GOC:dos] synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT [] synonym: "magnetoreception, detection of mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0050958 ! magnetoreception relationship: part_of GO:0050979 ! magnetoreception by sensory perception of mechanical stimulus [Term] id: GO:0050972 name: detection of mechanical stimulus involved in echolocation namespace: biological_process def: "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai, GOC:dos] synonym: "echolocation, detection of mechanical stimulus" EXACT [] synonym: "echolocation, sensory detection of mechanical stimulus" EXACT [] synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during echolocation" EXACT [] synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0050959 ! echolocation relationship: part_of GO:0050959 ! echolocation [Term] id: GO:0050973 name: detection of mechanical stimulus involved in equilibrioception namespace: biological_process def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos] synonym: "equilibrioception, detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT [] synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT [] synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0050957 ! equilibrioception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0050974 name: detection of mechanical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT [] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0050982 ! detection of mechanical stimulus intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0007600 ! sensory perception relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050975 name: sensory perception of touch namespace: biological_process def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] synonym: "perception of touch" EXACT [] synonym: "tactile sense" EXACT [] synonym: "taction" EXACT [] synonym: "tactition" EXACT [] xref: MIPS_funcat:36.25.01.05 xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050976 name: detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "perception of touch, detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT [] synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT [] synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT [] synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT [] synonym: "tactition, sensory detection of mechanical stimulus" EXACT [] is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0050975 ! sensory perception of touch relationship: part_of GO:0050975 ! sensory perception of touch [Term] id: GO:0050977 name: magnetoreception by sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] synonym: "magnetoreception by chemical stimulus" EXACT [] synonym: "magnetoreception through chemical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT [] synonym: "magnetoreception, using chemical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0007606 ! sensory perception of chemical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050978 name: magnetoreception by sensory perception of electrical stimulus namespace: biological_process def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] synonym: "magnetoreception by electrical stimulus" EXACT [] synonym: "magnetoreception through electrical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT [] synonym: "magnetoreception, using electrical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0050952 ! sensory perception of electrical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050979 name: magnetoreception by sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] synonym: "magnetoreception through mechanical stimulus" EXACT [] synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT [] synonym: "magnetoreception, using mechanical stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0050954 ! sensory perception of mechanical stimulus is_a: GO:0050958 ! magnetoreception [Term] id: GO:0050980 name: detection of light stimulus involved in magnetoreception namespace: biological_process def: "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception] synonym: "magnetoreception, detection of light stimulus" EXACT [] synonym: "magnetoreception, sensory detection of light stimulus" EXACT [] synonym: "magnetoreception, sensory transduction of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during magnetoreception" EXACT [] synonym: "sensory transduction of light stimulus during magnetoreception" EXACT [] is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0050958 ! magnetoreception relationship: part_of GO:0050958 ! magnetoreception [Term] id: GO:0050981 name: detection of electrical stimulus namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] xref: MIPS_funcat:34.11.08 is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0050982 name: detection of mechanical stimulus namespace: biological_process def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] xref: MIPS_funcat:34.11.05 is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0050983 name: obsolete deoxyhypusine biosynthetic process from spermidine namespace: biological_process def: "OBSOLETE. The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN] comment: The reason for obsoletion is that although GO:0050983 is described as a multistep process, the entire reaction is carried out by a single enzyme, therefore we would define it as the molecular function GO:0034038 deoxyhypusine synthase activity. synonym: "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46] synonym: "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46] synonym: "deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase" EXACT [] synonym: "deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase" EXACT [] synonym: "deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase" EXACT [] synonym: "deoxyhypusine formation from spermidine, using deoxyhypusine synthase" EXACT [] synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT [] synonym: "spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase" EXACT [] synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT [] xref: EC:2.5.1.46 xref: MetaCyc:2.5.1.46-RXN is_obsolete: true consider: GO:0034038 [Term] id: GO:0050984 name: peptidyl-serine sulfation namespace: biological_process def: "The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361] xref: RESID:AA0361 is_a: GO:0006477 ! protein sulfation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0050985 name: peptidyl-threonine sulfation namespace: biological_process def: "The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362] xref: RESID:AA0362 is_a: GO:0006477 ! protein sulfation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0050986 name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360] xref: RESID:AA0360 is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0050987 name: enzyme active site formation via O-sulfo-L-serine namespace: biological_process def: "The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361] xref: RESID:AA0361 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0050984 ! peptidyl-serine sulfation [Term] id: GO:0050988 name: N-terminal peptidyl-methionine carboxylation namespace: biological_process def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363] xref: RESID:AA0363 is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0050989 ! N-terminal protein amino acid carboxylation [Term] id: GO:0050989 name: N-terminal protein amino acid carboxylation namespace: biological_process def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai] is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0050990 name: N-terminal protein amino acid carbamoylation namespace: biological_process def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai] synonym: "N-terminal protein amino acid carbamylation" EXACT [] is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0050991 name: enzyme active site formation via O-sulfo-L-threonine namespace: biological_process def: "The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362] xref: RESID:AA0362 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0050985 ! peptidyl-threonine sulfation [Term] id: GO:0050992 name: dimethylallyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai] synonym: "dimethylallyl diphosphate anabolism" EXACT [] synonym: "dimethylallyl diphosphate biosynthesis" EXACT [] synonym: "dimethylallyl diphosphate formation" EXACT [] synonym: "dimethylallyl diphosphate synthesis" EXACT [] synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT [] synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT [] synonym: "DPP biosynthesis" EXACT [] synonym: "DPP biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process [Term] id: GO:0050993 name: dimethylallyl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai] synonym: "dimethylallyl diphosphate metabolism" EXACT [] synonym: "dimethylallyl pyrophosphate metabolic process" EXACT [] synonym: "dimethylallyl pyrophosphate metabolism" EXACT [] synonym: "DPP metabolic process" EXACT [] synonym: "DPP metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016042 ! lipid catabolic process relationship: regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016042 ! lipid catabolic process relationship: negatively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016042 ! lipid catabolic process relationship: positively_regulates GO:0016042 ! lipid catabolic process [Term] id: GO:0050997 name: quaternary ammonium group binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai] synonym: "quaternary amine binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0050998 name: nitric-oxide synthase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme nitric-oxide synthase." [GOC:ai] synonym: "NOS binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0050999 name: regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai] synonym: "nitric-oxide synthase regulator" EXACT [] synonym: "NOS regulator" EXACT [] synonym: "regulation of NOS activity" EXACT [] is_a: GO:0032768 ! regulation of monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004517 ! nitric-oxide synthase activity relationship: regulates GO:0004517 ! nitric-oxide synthase activity [Term] id: GO:0051000 name: positive regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai] synonym: "activation of nitric-oxide synthase activity" NARROW [] synonym: "nitric-oxide synthase activator" EXACT [] synonym: "NOS activator" EXACT [] synonym: "positive regulation of NOS activity" EXACT [] synonym: "stimulation of nitric-oxide synthase activity" NARROW [] synonym: "up regulation of nitric-oxide synthase activity" EXACT [] synonym: "up-regulation of nitric-oxide synthase activity" EXACT [] synonym: "upregulation of nitric-oxide synthase activity" EXACT [] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0050999 ! regulation of nitric-oxide synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004517 ! nitric-oxide synthase activity relationship: positively_regulates GO:0004517 ! nitric-oxide synthase activity [Term] id: GO:0051001 name: negative regulation of nitric-oxide synthase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai] synonym: "down regulation of nitric-oxide synthase activity" EXACT [] synonym: "down-regulation of nitric-oxide synthase activity" EXACT [] synonym: "downregulation of nitric-oxide synthase activity" EXACT [] synonym: "inhibition of nitric-oxide synthase activity" NARROW [] synonym: "negative regulation of NOS activity" EXACT [] synonym: "nitric-oxide synthase inhibitor" NARROW [] synonym: "NOS inhibitor" NARROW [] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0050999 ! regulation of nitric-oxide synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004517 ! nitric-oxide synthase activity relationship: negatively_regulates GO:0004517 ! nitric-oxide synthase activity [Term] id: GO:0051002 name: ligase activity, forming nitrogen-metal bonds namespace: molecular_function def: "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6, GOC:mah] xref: EC:6.6 is_a: GO:0016874 ! ligase activity [Term] id: GO:0051003 name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes namespace: molecular_function def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-] xref: EC:6.6.1 is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds [Term] id: GO:0051004 name: regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai] is_a: GO:0060191 ! regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004465 ! lipoprotein lipase activity relationship: regulates GO:0004465 ! lipoprotein lipase activity [Term] id: GO:0051005 name: negative regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai] synonym: "down regulation of lipoprotein lipase activity" EXACT [] synonym: "down-regulation of lipoprotein lipase activity" EXACT [] synonym: "downregulation of lipoprotein lipase activity" EXACT [] synonym: "inhibition of lipoprotein lipase activity" NARROW [] is_a: GO:0051004 ! regulation of lipoprotein lipase activity is_a: GO:0060192 ! negative regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004465 ! lipoprotein lipase activity relationship: negatively_regulates GO:0004465 ! lipoprotein lipase activity [Term] id: GO:0051006 name: positive regulation of lipoprotein lipase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai] synonym: "activation of lipoprotein lipase activity" NARROW [] synonym: "stimulation of lipoprotein lipase activity" NARROW [] synonym: "up regulation of lipoprotein lipase activity" EXACT [] synonym: "up-regulation of lipoprotein lipase activity" EXACT [] synonym: "upregulation of lipoprotein lipase activity" EXACT [] is_a: GO:0051004 ! regulation of lipoprotein lipase activity is_a: GO:0061365 ! positive regulation of triglyceride lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004465 ! lipoprotein lipase activity relationship: positively_regulates GO:0004465 ! lipoprotein lipase activity [Term] id: GO:0051007 name: squalene-hopene cyclase activity namespace: molecular_function def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17] synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17] synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.17 xref: MetaCyc:5.4.99.17-RXN is_a: GO:0016866 ! intramolecular transferase activity is_a: GO:0034072 ! squalene cyclase activity [Term] id: GO:0051008 name: Hsp27 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0051009 name: O-acetylhomoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822] xref: MetaCyc:ACETYLHOMOSER-CYS-RXN is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0051010 name: microtubule plus-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] is_a: GO:0008017 ! microtubule binding [Term] id: GO:0051011 name: microtubule minus-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] is_a: GO:0008017 ! microtubule binding [Term] id: GO:0051012 name: microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826] synonym: "microtubule translocation" EXACT [] is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0051013 name: microtubule severing namespace: biological_process def: "The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends" [GOC:ai, PMID:27037673] synonym: "microtubule severing activity" RELATED [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0051014 name: actin filament severing namespace: biological_process def: "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] synonym: "actin filament severing activity" RELATED [] synonym: "barbed-end actin capping/severing activity" RELATED [] synonym: "F-actin severing" EXACT [] is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0051015 name: actin filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] synonym: "actin cross-linking activity" RELATED [] synonym: "F-actin binding" EXACT [] is_a: GO:0003779 ! actin binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0051016 name: barbed-end actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "barbed-end actin capping activity" EXACT [] synonym: "barbed-end F-actin capping activity" EXACT [] synonym: "plus-end actin filament capping activity" EXACT [] synonym: "plus-end F-actin capping activity" EXACT [] is_a: GO:0051693 ! actin filament capping [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process alt_id: GO:0045011 def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061572 ! actin filament bundle organization [Term] id: GO:0051018 name: protein kinase A binding namespace: molecular_function def: "Interacting selectively and non-covalently with any subunit of protein kinase A." [GOC:ai] comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. synonym: "PKA binding" EXACT [] synonym: "protein kinase A anchoring activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051019 name: mitogen-activated protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase." [GOC:ai] synonym: "MAP kinase binding" EXACT [] synonym: "MAP-kinase anchoring activity" RELATED [] synonym: "MAPK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0051020 name: GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0051021 name: GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein." [GOC:ai] synonym: "GDI binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051022 name: Rho GDP-dissociation inhibitor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein." [GOC:ai] synonym: "Rho GDI binding" EXACT [] is_a: GO:0051021 ! GDP-dissociation inhibitor binding [Term] id: GO:0051023 name: regulation of immunoglobulin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai] synonym: "regulation of antibody secretion" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048305 ! immunoglobulin secretion relationship: regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051024 name: positive regulation of immunoglobulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai] synonym: "activation of immunoglobulin secretion" NARROW [] synonym: "positive regulation of antibody secretion" EXACT [] synonym: "stimulation of immunoglobulin secretion" NARROW [] synonym: "up regulation of immunoglobulin secretion" EXACT [] synonym: "up-regulation of immunoglobulin secretion" EXACT [] synonym: "upregulation of immunoglobulin secretion" EXACT [] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048305 ! immunoglobulin secretion relationship: positively_regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051025 name: negative regulation of immunoglobulin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai] synonym: "down regulation of immunoglobulin secretion" EXACT [] synonym: "down-regulation of immunoglobulin secretion" EXACT [] synonym: "downregulation of immunoglobulin secretion" EXACT [] synonym: "inhibition of immunoglobulin secretion" NARROW [] synonym: "negative regulation of antibody secretion" EXACT [] is_a: GO:0002638 ! negative regulation of immunoglobulin production is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0051023 ! regulation of immunoglobulin secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048305 ! immunoglobulin secretion relationship: negatively_regulates GO:0048305 ! immunoglobulin secretion [Term] id: GO:0051026 name: chiasma assembly namespace: biological_process def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007129 ! synapsis relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0051027 name: DNA transport namespace: biological_process def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport [Term] id: GO:0051028 name: mRNA transport namespace: biological_process def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051029 name: rRNA transport namespace: biological_process def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051030 name: snRNA transport namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051031 name: tRNA transport namespace: biological_process def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport [Term] id: GO:0051032 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity relationship: part_of GO:0050657 ! nucleic acid transport [Term] id: GO:0051033 name: RNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: MIPS_funcat:20.01.21 xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" is_a: GO:0051032 ! nucleic acid transmembrane transporter activity relationship: part_of GO:0050658 ! RNA transport [Term] id: GO:0051034 name: tRNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051033 ! RNA transmembrane transporter activity relationship: part_of GO:0051031 ! tRNA transport [Term] id: GO:0051035 name: DNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051032 ! nucleic acid transmembrane transporter activity relationship: part_of GO:0051027 ! DNA transport [Term] id: GO:0051036 name: regulation of endosome size namespace: biological_process def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai] synonym: "endosome enlargement" RELATED [] is_a: GO:0097494 ! regulation of vesicle size [Term] id: GO:0051037 name: regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators] synonym: "meiotic regulation of transcription" EXACT [] synonym: "regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0022414 ! reproductive process intersection_of: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051038 name: negative regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai] synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah] synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah] synonym: "meiotic repression of transcription" EXACT [] synonym: "negative regulation of meiotic transcription" EXACT [] synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051039 name: positive regulation of transcription involved in meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai] synonym: "activation of transcription during meiosis" NARROW [GOC:mah] synonym: "positive regulation of meiotic transcription" EXACT [] synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah] synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah] synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah] synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051040 name: regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [Term] id: GO:0051041 name: positive regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] synonym: "activation of calcium-independent cell-cell adhesion" NARROW [] synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW [] synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [Term] id: GO:0051042 name: negative regulation of calcium-independent cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT [] synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [Term] id: GO:0051043 name: regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006509 ! membrane protein ectodomain proteolysis relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051044 name: positive regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai] synonym: "activation of membrane protein ectodomain proteolysis" NARROW [] synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW [] synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051045 name: negative regulation of membrane protein ectodomain proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai] synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT [] synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046903 ! secretion relationship: regulates GO:0046903 ! secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046903 ! secretion relationship: positively_regulates GO:0046903 ! secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046903 ! secretion relationship: negatively_regulates GO:0046903 ! secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006810 ! transport relationship: regulates GO:0006810 ! transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006810 ! transport relationship: positively_regulates GO:0006810 ! transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006810 ! transport relationship: negatively_regulates GO:0006810 ! transport [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: goslim_yeast synonym: "regulation of DNA metabolism" EXACT [] xref: MIPS_funcat:10.01.11 is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006259 ! DNA metabolic process relationship: regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process relationship: negatively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006259 ! DNA metabolic process relationship: positively_regulates GO:0006259 ! DNA metabolic process [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008610 ! lipid biosynthetic process relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process [Term] id: GO:0051056 name: regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] synonym: "regulation of small GTPase-mediated signal transduction" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007264 ! small GTPase mediated signal transduction relationship: regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051057 name: positive regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] synonym: "activation of small GTPase mediated signal transduction" NARROW [] synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT [] synonym: "stimulation of small GTPase mediated signal transduction" NARROW [] synonym: "up regulation of small GTPase mediated signal transduction" EXACT [] synonym: "up-regulation of small GTPase mediated signal transduction" EXACT [] synonym: "upregulation of small GTPase mediated signal transduction" EXACT [] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007264 ! small GTPase mediated signal transduction relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051058 name: negative regulation of small GTPase mediated signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] synonym: "down regulation of small GTPase mediated signal transduction" EXACT [] synonym: "down-regulation of small GTPase mediated signal transduction" EXACT [] synonym: "downregulation of small GTPase mediated signal transduction" EXACT [] synonym: "inhibition of small GTPase mediated signal transduction" NARROW [] synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT [] is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0051059 name: NF-kappaB binding namespace: molecular_function def: "Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0051060 name: pullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41] synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT [] synonym: "amylopectin 6-glucanohydrolase activity" EXACT [] synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41] synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41] synonym: "pullulan 6-glucanohydrolase activity" EXACT [] synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41] synonym: "R-enzyme" RELATED [EC:3.2.1.41] xref: EC:3.2.1.41 xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051061 name: ADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] synonym: "ADP reduction" RELATED [] xref: MetaCyc:ADPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Term] id: GO:0051062 name: UDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] synonym: "UDP reduction" RELATED [] xref: MetaCyc:UDPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Term] id: GO:0051063 name: CDP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN] synonym: "CDP reduction" RELATED [] xref: MetaCyc:CDPREDUCT-RXN is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Term] id: GO:0051064 name: TTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "TTP reduction" RELATED [] xref: EC:1.17.4 is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity [Term] id: GO:0051065 name: CTP reductase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] synonym: "CTP reduction" RELATED [] xref: EC:1.17.4 is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity [Term] id: GO:0051066 name: dihydrobiopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [PMID:2557335] synonym: "6,7-dihydrobiopterin metabolic process" NARROW [CHEBI:20680] synonym: "7,8-dihydrobiopterin metabolic process" NARROW [CHEBI:15375] synonym: "dihydrobiopterin reduction" NARROW [] synonym: "dihydropterin metabolic process" EXACT [CHEBI:38797] synonym: "dihydropterin metabolism" EXACT [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0051067 name: dihydropteridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [PMID:2557335] synonym: "6,7-dihydropteridine metabolic process" EXACT [PMID:19567870] synonym: "dihydropteridine metabolism" EXACT [] synonym: "dihydropteridine reduction" NARROW [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0051068 name: dihydrolipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464] synonym: "dihydrolipoamide metabolism" EXACT [] synonym: "dihydrolipoamide reduction" NARROW [] synonym: "dihydrothioctamide metabolic process" EXACT [] synonym: "dihydrothioctamide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0051069 name: galactomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/] synonym: "galactomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0051070 name: galactomannan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] synonym: "galactomannan anabolism" EXACT [] synonym: "galactomannan biosynthesis" EXACT [] synonym: "galactomannan formation" EXACT [] synonym: "galactomannan synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0051069 ! galactomannan metabolic process [Term] id: GO:0051071 name: 4,6-pyruvylated galactose residue metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] synonym: "4,6-pyruvylated galactose residue metabolism" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT [] synonym: "PvGal metabolic process" EXACT [] synonym: "PvGal metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0051072 name: 4,6-pyruvylated galactose residue biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] synonym: "4,6-pyruvylated galactose residue anabolism" EXACT [] synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT [] synonym: "4,6-pyruvylated galactose residue formation" EXACT [] synonym: "4,6-pyruvylated galactose residue synthesis" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT [] synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT [] synonym: "PvGal biosynthesis" EXACT [] synonym: "PvGal biosynthetic process" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0051073 name: adenosylcobinamide-GDP ribazoletransferase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN] synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26] synonym: "cobalamin synthase activity" EXACT [] synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26] synonym: "CobS" RELATED [EC:2.7.8.26] xref: EC:2.7.8.26 xref: MetaCyc:COBALAMINSYN-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0051074 name: obsolete protein tetramerization activity namespace: molecular_function def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] comment: This term was made obsolete because it represents a process. synonym: "protein tetramerization activity" EXACT [] is_obsolete: true replaced_by: GO:0051262 [Term] id: GO:0051075 name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872] synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT [] is_a: GO:0016740 ! transferase activity is_a: GO:0016853 ! isomerase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0051077 name: secondary cell septum namespace: cellular_component def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] synonym: "secondary septum" BROAD [] is_a: GO:0000935 ! division septum [Term] id: GO:0051078 name: meiotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" EXACT [] synonym: "meiotic nuclear envelope catabolism" EXACT [] synonym: "meiotic nuclear envelope degradation" EXACT [] is_a: GO:0051081 ! nuclear envelope disassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051081 ! nuclear envelope disassembly intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051079 name: meiosis I nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf] synonym: "meiosis I nuclear envelope breakdown" EXACT [] synonym: "meiosis I nuclear envelope catabolism" EXACT [] synonym: "meiosis I nuclear envelope degradation" EXACT [] is_a: GO:0051078 ! meiotic nuclear envelope disassembly intersection_of: GO:0051081 ! nuclear envelope disassembly intersection_of: part_of GO:0007127 ! meiosis I relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0051080 name: meiosis II nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf] synonym: "meiosis II nuclear envelope breakdown" EXACT [] synonym: "meiosis II nuclear envelope catabolism" EXACT [] synonym: "meiosis II nuclear envelope degradation" EXACT [] is_a: GO:0051078 ! meiotic nuclear envelope disassembly intersection_of: GO:0051081 ! nuclear envelope disassembly intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0051081 name: nuclear envelope disassembly namespace: biological_process def: "The controlled breakdown of the nuclear envelope in the context of a normal process." [GOC:ai] synonym: "nuclear envelope breakdown" EXACT [] synonym: "nuclear envelope catabolism" EXACT [] synonym: "nuclear envelope degradation" EXACT [] is_a: GO:0006998 ! nuclear envelope organization is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0051082 name: unfolded protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "binding unfolded ER proteins" NARROW [] synonym: "chaperone activity" RELATED [] synonym: "fimbrium-specific chaperone activity" NARROW [] synonym: "glycoprotein-specific chaperone activity" NARROW [] synonym: "histone-specific chaperone activity" NARROW [] synonym: "ribosomal chaperone activity" NARROW [] synonym: "tubulin-specific chaperone activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051083 name: 'de novo' cotranslational protein folding namespace: biological_process alt_id: GO:0006444 def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb] synonym: "'de novo' co-translational protein folding" EXACT [] synonym: "multidomain protein assembly" EXACT [] synonym: "nascent polypeptide association" EXACT [] is_a: GO:0006458 ! 'de novo' protein folding [Term] id: GO:0051084 name: 'de novo' posttranslational protein folding namespace: biological_process def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] synonym: "'de novo' post-translational protein folding" EXACT [] is_a: GO:0006458 ! 'de novo' protein folding [Term] id: GO:0051085 name: chaperone cofactor-dependent protein refolding namespace: biological_process alt_id: GO:0070389 def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] comment: Merged chaperone_cofactor-dependent_protein_refolding and chaperone mediated protein folding requiring cofactor see https://github.com/geneontology/go-ontology/issues/10726 synonym: "chaperone co-factor-dependent protein folding" RELATED [] synonym: "chaperone co-factor-dependent protein refolding" EXACT [] synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah] synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb] synonym: "chaperone mediated protein folding requiring cofactor" RELATED [] is_a: GO:0051084 ! 'de novo' posttranslational protein folding is_a: GO:0061077 ! chaperone-mediated protein folding [Term] id: GO:0051086 name: chaperone mediated protein folding independent of cofactor namespace: biological_process def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb] is_a: GO:0051084 ! 'de novo' posttranslational protein folding is_a: GO:0061077 ! chaperone-mediated protein folding [Term] id: GO:0051087 name: chaperone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com] synonym: "chaperone protein binding" EXACT [] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051088 name: PMA-inducible membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508] is_a: GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051089 name: constitutive protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508] is_a: GO:0006509 ! membrane protein ectodomain proteolysis [Term] id: GO:0051090 name: regulation of DNA-binding transcription factor activity namespace: biological_process alt_id: GO:1904167 alt_id: GO:2000823 def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] synonym: "regulation of androgen receptor activity" NARROW [] synonym: "regulation of DNA binding transcription factor activity" EXACT [] synonym: "regulation of sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "regulation of thyroid hormone receptor activity" NARROW [] synonym: "regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] xref: MIPS_funcat:18.02.09 is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003700 ! DNA-binding transcription factor activity relationship: regulates GO:0003700 ! DNA-binding transcription factor activity [Term] id: GO:0051091 name: positive regulation of DNA-binding transcription factor activity namespace: biological_process alt_id: GO:1904169 def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] synonym: "activation of transcription factor activity" NARROW [] synonym: "positive regulation of DNA binding transcription factor activity" EXACT [] synonym: "positive regulation of sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "positive regulation of thyroid hormone receptor activity" NARROW [] synonym: "positive regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] synonym: "stimulation of transcription factor activity" NARROW [] synonym: "up regulation of transcription factor activity" EXACT [] synonym: "up-regulation of transcription factor activity" EXACT [] synonym: "upregulation of transcription factor activity" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003700 ! DNA-binding transcription factor activity relationship: positively_regulates GO:0003700 ! DNA-binding transcription factor activity created_by: rph creation_date: 2015-04-22T12:22:16Z [Term] id: GO:0051092 name: positive regulation of NF-kappaB transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030] synonym: "activation of NF-kappaB" EXACT [] synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "NF-kappaB activation" EXACT [] is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032502 ! developmental process relationship: negatively_regulates GO:0032502 ! developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032502 ! developmental process relationship: positively_regulates GO:0032502 ! developmental process [Term] id: GO:0051095 name: regulation of helicase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai] is_a: GO:0043462 ! regulation of ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004386 ! helicase activity relationship: regulates GO:0004386 ! helicase activity [Term] id: GO:0051096 name: positive regulation of helicase activity namespace: biological_process def: "Any process that activates or increases the activity of a helicase." [GOC:ai] synonym: "activation of helicase activity" NARROW [] synonym: "stimulation of helicase activity" NARROW [] synonym: "up regulation of helicase activity" EXACT [] synonym: "up-regulation of helicase activity" EXACT [] synonym: "upregulation of helicase activity" EXACT [] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:0051095 ! regulation of helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004386 ! helicase activity relationship: positively_regulates GO:0004386 ! helicase activity [Term] id: GO:0051097 name: negative regulation of helicase activity namespace: biological_process def: "Any process that stops or reduces the activity of a helicase." [GOC:ai] synonym: "down regulation of helicase activity" EXACT [] synonym: "down-regulation of helicase activity" EXACT [] synonym: "downregulation of helicase activity" EXACT [] synonym: "inhibition of helicase activity" NARROW [] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:0051095 ! regulation of helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004386 ! helicase activity relationship: negatively_regulates GO:0004386 ! helicase activity [Term] id: GO:0051098 name: regulation of binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005488 ! binding relationship: regulates GO:0005488 ! binding [Term] id: GO:0051099 name: positive regulation of binding namespace: biological_process def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] synonym: "activation of binding" NARROW [] synonym: "stimulation of binding" NARROW [] synonym: "up regulation of binding" EXACT [] synonym: "up-regulation of binding" EXACT [] synonym: "upregulation of binding" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005488 ! binding relationship: positively_regulates GO:0005488 ! binding [Term] id: GO:0051100 name: negative regulation of binding namespace: biological_process def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] synonym: "down regulation of binding" EXACT [] synonym: "down-regulation of binding" EXACT [] synonym: "downregulation of binding" EXACT [] synonym: "inhibition of binding" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005488 ! binding relationship: negatively_regulates GO:0005488 ! binding [Term] id: GO:0051101 name: regulation of DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003677 ! DNA binding relationship: regulates GO:0003677 ! DNA binding [Term] id: GO:0051102 name: DNA ligation involved in DNA recombination namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai] synonym: "DNA ligation during DNA recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0006266 ! DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0006310 ! DNA recombination relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0051103 name: DNA ligation involved in DNA repair namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai] synonym: "DNA ligation during DNA repair" RELATED [GOC:dph, GOC:tb] is_a: GO:0006266 ! DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0006281 ! DNA repair relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0051104 name: DNA-dependent DNA replication DNA ligation namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb] synonym: "DNA ligation during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] synonym: "DNA ligation involved in DNA-dependent DNA replication" EXACT [] is_a: GO:0006266 ! DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0006261 ! DNA-dependent DNA replication relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0051105 name: regulation of DNA ligation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006266 ! DNA ligation relationship: regulates GO:0006266 ! DNA ligation [Term] id: GO:0051106 name: positive regulation of DNA ligation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] synonym: "activation of DNA ligation" NARROW [] synonym: "stimulation of DNA ligation" NARROW [] synonym: "up regulation of DNA ligation" EXACT [] synonym: "up-regulation of DNA ligation" EXACT [] synonym: "upregulation of DNA ligation" EXACT [] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0051105 ! regulation of DNA ligation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006266 ! DNA ligation relationship: positively_regulates GO:0006266 ! DNA ligation [Term] id: GO:0051107 name: negative regulation of DNA ligation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] synonym: "down regulation of DNA ligation" EXACT [] synonym: "down-regulation of DNA ligation" EXACT [] synonym: "downregulation of DNA ligation" EXACT [] synonym: "inhibition of DNA ligation" NARROW [] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0051105 ! regulation of DNA ligation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006266 ! DNA ligation relationship: negatively_regulates GO:0006266 ! DNA ligation [Term] id: GO:0051108 name: carnitine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN] synonym: "carnitine synthetase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: MetaCyc:DCARNCOALIG-RXN xref: RHEA:30543 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0051109 name: crotonobetaine-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN] synonym: "crotonobetaine-CoA synthase activity" EXACT [] synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] xref: MetaCyc:CROTCOALIG-RXN xref: RHEA:30079 is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0051110 name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine namespace: biological_process def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] xref: RESID:AA0372 is_a: GO:0051114 ! peptidyl-histidine uridylylation [Term] id: GO:0051111 name: peptidyl-histidine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371] xref: RESID:AA0371 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0051112 name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine namespace: biological_process def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] xref: RESID:AA0371 is_a: GO:0051111 ! peptidyl-histidine adenylylation [Term] id: GO:0051113 name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine namespace: biological_process def: "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] xref: RESID:AA0371 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0051112 ! peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine [Term] id: GO:0051114 name: peptidyl-histidine uridylylation namespace: biological_process def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372] xref: RESID:AA0372 is_a: GO:0018177 ! protein uridylylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0051115 name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine namespace: biological_process def: "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] xref: RESID:AA0372 is_a: GO:0018307 ! enzyme active site formation is_a: GO:0051110 ! peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine [Term] id: GO:0051116 name: cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15341] synonym: "CobN-CobST" RELATED [EC:6.6.1.2] synonym: "CobNST" NARROW [] synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT [] synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2] xref: EC:6.6.1.2 xref: KEGG_REACTION:R05227 xref: MetaCyc:R342-RXN xref: RHEA:15341 is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: GO:0051117 name: ATPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0051118 name: glucan endo-1,3-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59] synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59] synonym: "cariogenanase activity" EXACT [EC:3.2.1.59] synonym: "cariogenase activity" EXACT [EC:3.2.1.59] synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59] synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59] synonym: "mutanase activity" EXACT [EC:3.2.1.59] xref: EC:3.2.1.59 xref: MetaCyc:3.2.1.59-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0051119 name: sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sugar/polyol channel activity" NARROW [] xref: MIPS_funcat:20.01.03.01 xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose" xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051120 name: hepoxilin A3 synthase activity namespace: molecular_function def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652] xref: Reactome:R-HSA-2161794 "Arachidonic acid is converted to HXA3/B3 by ALOX12" xref: Reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3" is_a: GO:0016853 ! isomerase activity [Term] id: GO:0051121 name: hepoxilin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652] synonym: "hepoxilin metabolism" EXACT [] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0051122 name: hepoxilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai] synonym: "hepoxilin anabolism" EXACT [] synonym: "hepoxilin biosynthesis" EXACT [] synonym: "hepoxilin formation" EXACT [] synonym: "hepoxilin synthesis" EXACT [] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:0051121 ! hepoxilin metabolic process [Term] id: GO:0051123 name: RNA polymerase II preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047] synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT [] synonym: "RNA polymerase II transcription PIC formation" EXACT [] synonym: "RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0051124 name: synaptic growth at neuromuscular junction namespace: biological_process def: "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544] synonym: "cholinergic synaptogenesis" RELATED [] is_a: GO:0007416 ! synapse assembly is_a: GO:0007528 ! neuromuscular junction development is_a: GO:0048589 ! developmental growth [Term] id: GO:0051125 name: regulation of actin nucleation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] is_a: GO:0030833 ! regulation of actin filament polymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045010 ! actin nucleation relationship: regulates GO:0045010 ! actin nucleation [Term] id: GO:0051126 name: negative regulation of actin nucleation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] synonym: "down regulation of actin nucleation" EXACT [] synonym: "down-regulation of actin nucleation" EXACT [] synonym: "downregulation of actin nucleation" EXACT [] synonym: "inhibition of actin nucleation" NARROW [] is_a: GO:0051125 ! regulation of actin nucleation is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045010 ! actin nucleation relationship: negatively_regulates GO:0045010 ! actin nucleation [Term] id: GO:0051127 name: positive regulation of actin nucleation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] synonym: "activation of actin nucleation" NARROW [] synonym: "stimulation of actin nucleation" NARROW [] synonym: "up regulation of actin nucleation" EXACT [] synonym: "up-regulation of actin nucleation" EXACT [] synonym: "upregulation of actin nucleation" EXACT [] is_a: GO:0030838 ! positive regulation of actin filament polymerization is_a: GO:0051125 ! regulation of actin nucleation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045010 ! actin nucleation relationship: positively_regulates GO:0045010 ! actin nucleation [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016043 ! cellular component organization relationship: regulates GO:0016043 ! cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016043 ! cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016043 ! cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization [Term] id: GO:0051131 name: chaperone-mediated protein complex assembly namespace: biological_process alt_id: GO:0034619 def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] synonym: "cellular chaperone-mediated protein complex assembly" EXACT [] synonym: "chaperone activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0051132 name: NK T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments. synonym: "natural killer T cell activation" EXACT [] synonym: "natural T cell activation" EXACT [] synonym: "NK T lymphocyte activation" EXACT [] synonym: "NK T-cell activation" EXACT [] synonym: "NK T-lymphocyte activation" EXACT [] synonym: "NKT cell activation" EXACT [] synonym: "NT cell activation" EXACT [] is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0051133 name: regulation of NK T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell activation" EXACT [] synonym: "regulation of natural T cell activation" EXACT [] synonym: "regulation of NK T lymphocyte activation" EXACT [] synonym: "regulation of NK T-cell activation" EXACT [] synonym: "regulation of NK T-lymphocyte activation" EXACT [] synonym: "regulation of NKT cell activation" EXACT [] synonym: "regulation of NT cell activation" EXACT [] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051132 ! NK T cell activation relationship: regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051134 name: negative regulation of NK T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell activation" EXACT [] synonym: "down-regulation of NK T cell activation" EXACT [] synonym: "downregulation of NK T cell activation" EXACT [] synonym: "inhibition of NK T cell activation" NARROW [] synonym: "negative regulation of natural killer T cell activation" EXACT [] synonym: "negative regulation of natural T cell activation" EXACT [] synonym: "negative regulation of NK T lymphocyte activation" EXACT [] synonym: "negative regulation of NK T-cell activation" EXACT [] synonym: "negative regulation of NK T-lymphocyte activation" EXACT [] synonym: "negative regulation of NKT cell activation" EXACT [] synonym: "negative regulation of NT cell activation" EXACT [] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051132 ! NK T cell activation relationship: negatively_regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051135 name: positive regulation of NK T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "activation of NK T cell activation" NARROW [] synonym: "positive regulation of natural killer T cell activation" EXACT [] synonym: "positive regulation of natural T cell activation" EXACT [] synonym: "positive regulation of NK T lymphocyte activation" EXACT [] synonym: "positive regulation of NK T-cell activation" EXACT [] synonym: "positive regulation of NK T-lymphocyte activation" EXACT [] synonym: "positive regulation of NKT cell activation" EXACT [] synonym: "positive regulation of NT cell activation" EXACT [] synonym: "stimulation of NK T cell activation" NARROW [] synonym: "up regulation of NK T cell activation" EXACT [] synonym: "up-regulation of NK T cell activation" EXACT [] synonym: "upregulation of NK T cell activation" EXACT [] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051132 ! NK T cell activation relationship: positively_regulates GO:0051132 ! NK T cell activation [Term] id: GO:0051136 name: regulation of NK T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer T cell differentiation" EXACT [] synonym: "regulation of natural T cell differentiation" EXACT [] synonym: "regulation of NK T cell development" RELATED [GOC:add] synonym: "regulation of NK T lymphocyte differentiation" EXACT [] synonym: "regulation of NK T-cell differentiation" EXACT [] synonym: "regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "regulation of NKT cell differentiation" EXACT [] synonym: "regulation of NT cell differentiation" EXACT [] is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001865 ! NK T cell differentiation relationship: regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051137 name: negative regulation of NK T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of NK T cell differentiation" EXACT [] synonym: "down-regulation of NK T cell differentiation" EXACT [] synonym: "downregulation of NK T cell differentiation" EXACT [] synonym: "inhibition of NK T cell differentiation" NARROW [] synonym: "negative regulation of natural killer T cell differentiation" EXACT [] synonym: "negative regulation of natural T cell differentiation" EXACT [] synonym: "negative regulation of NK T cell development" RELATED [GOC:add] synonym: "negative regulation of NK T lymphocyte differentiation" EXACT [] synonym: "negative regulation of NK T-cell differentiation" EXACT [] synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "negative regulation of NKT cell differentiation" EXACT [] synonym: "negative regulation of NT cell differentiation" EXACT [] is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001865 ! NK T cell differentiation relationship: negatively_regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051138 name: positive regulation of NK T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of NK T cell differentiation" NARROW [] synonym: "positive regulation of natural killer T cell differentiation" EXACT [] synonym: "positive regulation of natural T cell differentiation" EXACT [] synonym: "positive regulation of NK T cell development" RELATED [GOC:add] synonym: "positive regulation of NK T lymphocyte differentiation" EXACT [] synonym: "positive regulation of NK T-cell differentiation" EXACT [] synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT [] synonym: "positive regulation of NKT cell differentiation" EXACT [] synonym: "positive regulation of NT cell differentiation" EXACT [] synonym: "stimulation of NK T cell differentiation" NARROW [] synonym: "up regulation of NK T cell differentiation" EXACT [] synonym: "up-regulation of NK T cell differentiation" EXACT [] synonym: "upregulation of NK T cell differentiation" EXACT [] is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation is_a: GO:0051136 ! regulation of NK T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001865 ! NK T cell differentiation relationship: positively_regulates GO:0001865 ! NK T cell differentiation [Term] id: GO:0051139 name: metal ion:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg] synonym: "metal ion:hydrogen antiporter activity" EXACT [] xref: Reactome:R-HSA-435171 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages" is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0051140 name: regulation of NK T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "regulation of natural killer T cell proliferation" EXACT [] synonym: "regulation of natural T cell proliferation" EXACT [] synonym: "regulation of NK T lymphocyte proliferation" EXACT [] synonym: "regulation of NK T-cell proliferation" EXACT [] synonym: "regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "regulation of NKT cell proliferation" EXACT [] synonym: "regulation of NT cell proliferation" EXACT [] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:0051133 ! regulation of NK T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001866 ! NK T cell proliferation relationship: regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051141 name: negative regulation of NK T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "down regulation of NK T cell proliferation" EXACT [] synonym: "down-regulation of NK T cell proliferation" EXACT [] synonym: "downregulation of NK T cell proliferation" EXACT [] synonym: "inhibition of NK T cell proliferation" NARROW [] synonym: "negative regulation of natural killer T cell proliferation" EXACT [] synonym: "negative regulation of natural T cell proliferation" EXACT [] synonym: "negative regulation of NK T lymphocyte proliferation" EXACT [] synonym: "negative regulation of NK T-cell proliferation" EXACT [] synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "negative regulation of NKT cell proliferation" EXACT [] synonym: "negative regulation of NT cell proliferation" EXACT [] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:0051134 ! negative regulation of NK T cell activation is_a: GO:0051140 ! regulation of NK T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001866 ! NK T cell proliferation relationship: negatively_regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051142 name: positive regulation of NK T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] synonym: "activation of NK T cell proliferation" NARROW [] synonym: "positive regulation of natural killer T cell proliferation" EXACT [] synonym: "positive regulation of natural T cell proliferation" EXACT [] synonym: "positive regulation of NK T lymphocyte proliferation" EXACT [] synonym: "positive regulation of NK T-cell proliferation" EXACT [] synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT [] synonym: "positive regulation of NKT cell proliferation" EXACT [] synonym: "positive regulation of NT cell proliferation" EXACT [] synonym: "stimulation of NK T cell proliferation" NARROW [] synonym: "up regulation of NK T cell proliferation" EXACT [] synonym: "up-regulation of NK T cell proliferation" EXACT [] synonym: "upregulation of NK T cell proliferation" EXACT [] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:0051135 ! positive regulation of NK T cell activation is_a: GO:0051140 ! regulation of NK T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001866 ! NK T cell proliferation relationship: positively_regulates GO:0001866 ! NK T cell proliferation [Term] id: GO:0051143 name: propanediol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com] synonym: "1,2-dihydroxypropane metabolic process" EXACT [] synonym: "1,2-dihydroxypropane metabolism" EXACT [] synonym: "propanediol metabolism" EXACT [] synonym: "propylene glycol metabolic process" EXACT [] synonym: "propylene glycol metabolism" EXACT [] is_a: GO:0042844 ! glycol metabolic process [Term] id: GO:0051144 name: propanediol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai] synonym: "1,2-dihydroxypropane catabolic process" EXACT [] synonym: "1,2-dihydroxypropane catabolism" EXACT [] synonym: "propanediol breakdown" EXACT [] synonym: "propanediol catabolism" EXACT [] synonym: "propanediol degradation" EXACT [] synonym: "propylene glycol catabolic process" EXACT [] synonym: "propylene glycol catabolism" EXACT [] is_a: GO:0042846 ! glycol catabolic process is_a: GO:0051143 ! propanediol metabolic process [Term] id: GO:0051145 name: smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] synonym: "nonstriated muscle cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042692 ! muscle cell differentiation relationship: regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042692 ! muscle cell differentiation relationship: negatively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042692 ! muscle cell differentiation relationship: positively_regulates GO:0042692 ! muscle cell differentiation [Term] id: GO:0051150 name: regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051145 ! smooth muscle cell differentiation relationship: regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051151 name: negative regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "down regulation of smooth muscle cell differentiation" EXACT [] synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] synonym: "downregulation of smooth muscle cell differentiation" EXACT [] synonym: "inhibition of smooth muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051145 ! smooth muscle cell differentiation relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051152 name: positive regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "activation of smooth muscle cell differentiation" NARROW [] synonym: "stimulation of smooth muscle cell differentiation" NARROW [] synonym: "up regulation of smooth muscle cell differentiation" EXACT [] synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] synonym: "upregulation of smooth muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051145 ! smooth muscle cell differentiation relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051146 ! striated muscle cell differentiation relationship: regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051146 ! striated muscle cell differentiation relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051146 ! striated muscle cell differentiation relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0051156 name: glucose 6-phosphate metabolic process namespace: biological_process alt_id: GO:0006010 def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] synonym: "glucose 6-phosphate metabolism" EXACT [] synonym: "glucose 6-phosphate utilization" RELATED [GOC:mah] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0051157 name: arabitol catabolic process namespace: biological_process alt_id: GO:0019591 def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "arabitol breakdown" EXACT [] synonym: "arabitol catabolism" EXACT [] synonym: "arabitol degradation" EXACT [] synonym: "arabitol utilization" RELATED [GOC:mah] is_a: GO:0019527 ! pentitol catabolic process is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051158 name: L-arabitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "L-arabitol breakdown" EXACT [] synonym: "L-arabitol catabolism" EXACT [] synonym: "L-arabitol degradation" EXACT [] is_a: GO:0051157 ! arabitol catabolic process is_a: GO:0051162 ! L-arabitol metabolic process [Term] id: GO:0051159 name: D-arabitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "D-arabitol breakdown" EXACT [] synonym: "D-arabitol catabolism" EXACT [] synonym: "D-arabitol degradation" EXACT [] is_a: GO:0051157 ! arabitol catabolic process is_a: GO:0051163 ! D-arabitol metabolic process [Term] id: GO:0051160 name: L-xylitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai] synonym: "L-xylitol breakdown" EXACT [] synonym: "L-xylitol catabolism" EXACT [] synonym: "L-xylitol degradation" EXACT [] is_a: GO:0019527 ! pentitol catabolic process is_a: GO:0051164 ! L-xylitol metabolic process [Term] id: GO:0051161 name: arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "arabitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0051162 name: L-arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "L-arabitol metabolism" EXACT [] is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051163 name: D-arabitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "D-arabitol metabolism" EXACT [] is_a: GO:0051161 ! arabitol metabolic process [Term] id: GO:0051164 name: L-xylitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com] synonym: "L-xylitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0051165 name: 2,5-dihydroxypyridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai] synonym: "2,5-dihydroxypyridine metabolism" EXACT [] synonym: "pyridine-2,5-diol metabolic process" EXACT [CHEBI:16364] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0051166 name: 2,5-dihydroxypyridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai] synonym: "2,5-dihydroxypyridine breakdown" EXACT [] synonym: "2,5-dihydroxypyridine catabolism" EXACT [] synonym: "2,5-dihydroxypyridine degradation" EXACT [] synonym: "pyridine-2,5-diol catabolic process" EXACT [CHEBI:16364] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0051167 name: xylulose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544] synonym: "D-xylulose 5-phosphate metabolic process" EXACT [] synonym: "D-xylulose 5-phosphate metabolism" EXACT [] synonym: "D-xylulose-5-phosphate metabolic process" EXACT [] synonym: "D-xylulose-5-phosphate metabolism" EXACT [] synonym: "xylulose 5-phosphate metabolism" EXACT [] synonym: "xylulose-5-phosphate metabolic process" EXACT [] synonym: "xylulose-5-phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0051168 name: nuclear export namespace: biological_process def: "The directed movement of substances out of the nucleus." [GOC:ai] synonym: "export from nucleus" EXACT [] synonym: "nucleus export" EXACT [] synonym: "substance nuclear export" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: MIPS_funcat:20.09.01 xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0051170 name: import into nucleus namespace: biological_process alt_id: GO:1902593 def: "The directed movement of substances into the nucleus." [GOC:ai] synonym: "nuclear import" EXACT [] synonym: "single organism nuclear import" EXACT [GOC:TermGenie] synonym: "single-organism nuclear import" RELATED [] synonym: "substance nuclear import" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport created_by: jl creation_date: 2013-12-19T15:26:34Z [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006793 ! phosphorus metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0051175 name: negative regulation of sulfur metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "down regulation of sulfur metabolic process" EXACT [] synonym: "down-regulation of sulfur metabolic process" EXACT [] synonym: "downregulation of sulfur metabolic process" EXACT [] synonym: "inhibition of sulfur metabolic process" NARROW [] synonym: "negative regulation of sulfur metabolism" EXACT [] synonym: "negative regulation of sulphur metabolic process" EXACT [] synonym: "negative regulation of sulphur metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006790 ! sulfur compound metabolic process relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051176 name: positive regulation of sulfur metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] synonym: "activation of sulfur metabolic process" NARROW [] synonym: "positive regulation of sulfur metabolism" EXACT [] synonym: "positive regulation of sulphur metabolic process" EXACT [] synonym: "positive regulation of sulphur metabolism" EXACT [] synonym: "stimulation of sulfur metabolic process" NARROW [] synonym: "up regulation of sulfur metabolic process" EXACT [] synonym: "up-regulation of sulfur metabolic process" EXACT [] synonym: "upregulation of sulfur metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006790 ! sulfur compound metabolic process relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051177 name: meiotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0051178 name: meiotic chromosome decondensation namespace: biological_process def: "The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai] is_a: GO:0051312 ! chromosome decondensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0051312 ! chromosome decondensation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051180 name: vitamin transport namespace: biological_process def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir synonym: "vitamin or cofactor transport" BROAD [] xref: MIPS_funcat:20.01.25 is_a: GO:0006810 ! transport [Term] id: GO:0051181 name: cofactor transport namespace: biological_process def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: goslim_pir synonym: "vitamin or cofactor transport" BROAD [] xref: MIPS_funcat:20.01.25 is_a: GO:0006810 ! transport [Term] id: GO:0051182 name: coenzyme transport namespace: biological_process def: "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0051184 name: cofactor transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] synonym: "cofactor transporter activity" RELATED [] synonym: "vitamin or cofactor transporter activity" BROAD [] xref: MIPS_funcat:20.01.25 is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0051181 ! cofactor transport [Term] id: GO:0051185 name: coenzyme transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] synonym: "coenzyme transporter activity" RELATED [] is_a: GO:0051184 ! cofactor transmembrane transporter activity relationship: part_of GO:0051182 ! coenzyme transport [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "cofactor metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0051187 name: cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] synonym: "cofactor breakdown" EXACT [] synonym: "cofactor catabolism" EXACT [] synonym: "cofactor degradation" EXACT [] xref: MIPS_funcat:01.07.03 is_a: GO:0044248 ! cellular catabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051188 name: cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] synonym: "cofactor anabolism" EXACT [] synonym: "cofactor biosynthesis" EXACT [] synonym: "cofactor formation" EXACT [] synonym: "cofactor synthesis" EXACT [] xref: MIPS_funcat:01.07.01 is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051189 name: prosthetic group metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] subset: goslim_pir synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "prosthetic group metabolism" EXACT [] xref: MIPS_funcat:01.07 is_a: GO:0051186 ! cofactor metabolic process relationship: part_of GO:0044267 ! cellular protein metabolic process [Term] id: GO:0051190 name: prosthetic group catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "prosthetic group breakdown" EXACT [] synonym: "prosthetic group catabolism" EXACT [] synonym: "prosthetic group degradation" EXACT [] xref: MIPS_funcat:01.07.03 is_a: GO:0051187 ! cofactor catabolic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0044257 ! cellular protein catabolic process [Term] id: GO:0051191 name: prosthetic group biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "prosthetic group anabolism" EXACT [] synonym: "prosthetic group biosynthesis" EXACT [] synonym: "prosthetic group formation" EXACT [] synonym: "prosthetic group synthesis" EXACT [] xref: MIPS_funcat:01.07.01 is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051192 name: prosthetic group binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw] is_a: GO:0048037 ! cofactor binding [Term] id: GO:0051193 name: regulation of cofactor metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "regulation of cofactor metabolism" EXACT [] xref: MIPS_funcat:01.07.07 is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051186 ! cofactor metabolic process relationship: regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051194 name: positive regulation of cofactor metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "activation of cofactor metabolic process" NARROW [] synonym: "positive regulation of cofactor metabolism" EXACT [] synonym: "stimulation of cofactor metabolic process" NARROW [] synonym: "up regulation of cofactor metabolic process" EXACT [] synonym: "up-regulation of cofactor metabolic process" EXACT [] synonym: "upregulation of cofactor metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051186 ! cofactor metabolic process relationship: positively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051195 name: negative regulation of cofactor metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] synonym: "down regulation of cofactor metabolic process" EXACT [] synonym: "down-regulation of cofactor metabolic process" EXACT [] synonym: "downregulation of cofactor metabolic process" EXACT [] synonym: "inhibition of cofactor metabolic process" NARROW [] synonym: "negative regulation of cofactor metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051186 ! cofactor metabolic process relationship: negatively_regulates GO:0051186 ! cofactor metabolic process [Term] id: GO:0051196 name: regulation of coenzyme metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of coenzyme metabolism" EXACT [] is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006732 ! coenzyme metabolic process relationship: regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051197 name: positive regulation of coenzyme metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "activation of coenzyme metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "positive regulation of coenzyme metabolism" EXACT [] synonym: "stimulation of coenzyme metabolic process" NARROW [] synonym: "up regulation of coenzyme metabolic process" EXACT [] synonym: "up-regulation of coenzyme metabolic process" EXACT [] synonym: "upregulation of coenzyme metabolic process" EXACT [] is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006732 ! coenzyme metabolic process relationship: positively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051198 name: negative regulation of coenzyme metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] synonym: "down regulation of coenzyme metabolic process" EXACT [] synonym: "down-regulation of coenzyme metabolic process" EXACT [] synonym: "downregulation of coenzyme metabolic process" EXACT [] synonym: "inhibition of coenzyme metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of coenzyme metabolism" EXACT [] is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006732 ! coenzyme metabolic process relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process [Term] id: GO:0051199 name: regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of prosthetic group metabolism" EXACT [] xref: MIPS_funcat:01.07.07 is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051189 ! prosthetic group metabolic process relationship: regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051200 name: positive regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] synonym: "activation of prosthetic group metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "positive regulation of prosthetic group metabolism" EXACT [] synonym: "stimulation of prosthetic group metabolic process" NARROW [] synonym: "up regulation of prosthetic group metabolic process" EXACT [] synonym: "up-regulation of prosthetic group metabolic process" EXACT [] synonym: "upregulation of prosthetic group metabolic process" EXACT [] is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051189 ! prosthetic group metabolic process relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051201 name: negative regulation of prosthetic group metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] synonym: "down regulation of prosthetic group metabolic process" EXACT [] synonym: "down-regulation of prosthetic group metabolic process" EXACT [] synonym: "downregulation of prosthetic group metabolic process" EXACT [] synonym: "inhibition of prosthetic group metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of prosthetic group metabolism" EXACT [] is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051189 ! prosthetic group metabolic process relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0051202 name: phytochromobilin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553] synonym: "phytochromobilin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051203 name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde namespace: biological_process def: "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373] comment: See also UniProtKB:P04160. synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT [] synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT [] xref: RESID:AA0373 is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0051204 name: protein insertion into mitochondrial membrane namespace: biological_process def: "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai] synonym: "integral mitochondrial membrane protein localization" EXACT [] synonym: "integral mitochondrial membrane protein positioning" EXACT [] synonym: "localization of protein in mitochondrial membrane" EXACT [] synonym: "positioning of protein in mitochondrial membrane" EXACT [] synonym: "protein insertion into mitochondrion membrane" EXACT [] synonym: "protein-mitochondrial membrane insertion" EXACT [] synonym: "protein-mitochondrion membrane insertion" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0051205 ! protein insertion into membrane is_a: GO:0072655 ! establishment of protein localization to mitochondrion relationship: part_of GO:0070585 ! protein localization to mitochondrion [Term] id: GO:0051205 name: protein insertion into membrane namespace: biological_process def: "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai] synonym: "integral membrane protein localization" EXACT [] synonym: "integral membrane protein positioning" EXACT [] synonym: "membrane protein localization" EXACT [] synonym: "membrane protein positioning" EXACT [] synonym: "protein-membrane insertion" EXACT [] is_a: GO:0090150 ! establishment of protein localization to membrane relationship: part_of GO:0034613 ! cellular protein localization relationship: part_of GO:0061024 ! membrane organization [Term] id: GO:0051206 name: silicate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] synonym: "silicate metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0051208 name: sequestering of calcium ion namespace: biological_process def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "calcium ion (Ca2+) retention" EXACT [] synonym: "calcium ion (Ca2+) sequestering" EXACT [] synonym: "calcium ion (Ca2+) sequestration" EXACT [] synonym: "calcium ion (Ca2+) storage" EXACT [] synonym: "calcium ion storage activity" RELATED [] synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] synonym: "retention of calcium ion (Ca2+)" EXACT [] synonym: "sequestering of calcium ion (Ca2+)" EXACT [] synonym: "sequestration of calcium ion (Ca2+)" EXACT [] synonym: "storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0051209 name: release of sequestered calcium ion into cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] synonym: "calcium ion (Ca2+) mobilization" BROAD [] synonym: "calcium mobilization" BROAD [] synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+)" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion is_a: GO:0097553 ! calcium ion transmembrane import into cytosol [Term] id: GO:0051210 name: isotropic cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid] synonym: "uniform cell growth" RELATED [] xref: MIPS_funcat:40.01.01 is_a: GO:0016049 ! cell growth [Term] id: GO:0051211 name: anisotropic cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai] synonym: "non-isotropic cell growth" EXACT [] xref: MIPS_funcat:40.01.03 is_a: GO:0016049 ! cell growth [Term] id: GO:0051212 name: vanadium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with vanadium (V) ions." [GOC:ai] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0051213 name: dioxygenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf] subset: goslim_pir xref: Reactome:R-HSA-112120 "Oxidative demethylation of 3-meC damaged DNA by ALKBH2" xref: Reactome:R-HSA-112121 "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2" xref: Reactome:R-HSA-112124 "Oxidative demethylation of 3-meC damaged DNA By ALKBH3" xref: Reactome:R-HSA-112125 "Oxidative dealkylation of 1-EtA damaged DNA by ABH3" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0051214 name: RNA virus induced gene silencing namespace: biological_process def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] synonym: "RNA VIGS" EXACT [] synonym: "RNA virus-induced gene silencing" EXACT [] is_a: GO:0009616 ! virus induced gene silencing [Term] id: GO:0051215 name: DNA virus induced gene silencing namespace: biological_process def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] synonym: "DNA VIGS" EXACT [] synonym: "DNA virus-induced gene silencing" EXACT [] is_a: GO:0009616 ! virus induced gene silencing [Term] id: GO:0051216 name: cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [DOI:10.1371/journal.pone.0051070, GOC:cjm, http://www.onelook.com] synonym: "cartilage biogenesis" EXACT [] synonym: "cartilage biosynthesis" EXACT [] synonym: "cartilage element development" EXACT [] synonym: "cartilage formation" EXACT [] synonym: "cartilage organ development" EXACT [] synonym: "chondrogenesis" EXACT [] xref: MIPS_funcat:45.03.05.05 xref: Wikipedia:Chondrogenesis is_a: GO:0048513 ! animal organ development relationship: part_of GO:0001501 ! skeletal system development relationship: part_of GO:0061448 ! connective tissue development [Term] id: GO:0051217 name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375] xref: RESID:AA0375 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0051218 name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376] xref: RESID:AA02376 is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0051219 name: phosphoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated protein." [GOC:ai] subset: goslim_chembl synonym: "phosphorylated protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051220 name: cytoplasmic sequestering of protein namespace: biological_process def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai] synonym: "cytoplasmic retention of protein" EXACT [] synonym: "cytoplasmic sequestration of protein" EXACT [] synonym: "cytoplasmic storage of protein" EXACT [] synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] synonym: "retention of protein in cytoplasm" EXACT [] synonym: "sequestering of protein in cytoplasm" EXACT [] synonym: "sequestration of protein in cytoplasm" EXACT [] synonym: "storage of protein in cytoplasm" EXACT [] is_a: GO:0045185 ! maintenance of protein location [Term] id: GO:0051221 name: tungsten incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai] synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015031 ! protein transport relationship: positively_regulates GO:0015031 ! protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015031 ! protein transport relationship: regulates GO:0015031 ! protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015031 ! protein transport relationship: negatively_regulates GO:0015031 ! protein transport [Term] id: GO:0051225 name: spindle assembly namespace: biological_process alt_id: GO:0051226 alt_id: GO:0051227 def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] synonym: "bipolar spindle biosynthesis" EXACT [] synonym: "bipolar spindle formation" EXACT [] synonym: "spindle biosynthesis" EXACT [] synonym: "spindle formation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0070925 ! organelle assembly [Term] id: GO:0051228 name: mitotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] synonym: "mitotic spindle breakdown" EXACT [] synonym: "mitotic spindle catabolism" EXACT [] synonym: "mitotic spindle degradation" EXACT [] synonym: "spindle breakdown during mitosis" EXACT [] synonym: "spindle degradation during mitosis" EXACT [] synonym: "spindle disassembly during mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051230 ! spindle disassembly intersection_of: GO:0051230 ! spindle disassembly intersection_of: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0051229 name: meiotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "meiotic spindle breakdown" EXACT [] synonym: "meiotic spindle catabolism" EXACT [] synonym: "meiotic spindle degradation" EXACT [] synonym: "spindle breakdown during meiosis" EXACT [] synonym: "spindle degradation during meiosis" EXACT [] synonym: "spindle disassembly during meiosis" EXACT [] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051230 ! spindle disassembly intersection_of: GO:0051230 ! spindle disassembly intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051230 name: spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai] synonym: "spindle breakdown" EXACT [] synonym: "spindle catabolism" EXACT [] synonym: "spindle degradation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:1903008 ! organelle disassembly [Term] id: GO:0051231 name: spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007051 ! spindle organization relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0051232 name: meiotic spindle elongation namespace: biological_process def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] synonym: "spindle elongation during meiosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051231 ! spindle elongation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0000212 ! meiotic spindle organization relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051233 name: spindle midzone namespace: cellular_component def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "central spindle" EXACT [PMID:14528012] synonym: "spindle equator" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005819 ! spindle [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051235 name: maintenance of location namespace: biological_process def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of localization" EXACT [] synonym: "retention" NARROW [] synonym: "sequestering" NARROW [] synonym: "storage" NARROW [] is_a: GO:0051179 ! localization is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051237 name: maintenance of RNA location namespace: biological_process def: "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai] synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb] synonym: "RNA retention" EXACT [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0006403 ! RNA localization [Term] id: GO:0051238 name: sequestering of metal ion namespace: biological_process def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "metal ion retention" EXACT [] synonym: "metal ion sequestering" EXACT [] synonym: "metal ion sequestration" EXACT [] synonym: "metal ion storage" EXACT [] synonym: "retention of metal ion" EXACT [] synonym: "sequestration of metal ion" EXACT [] synonym: "storage of metal ion" EXACT [] is_a: GO:0051235 ! maintenance of location [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032501 ! multicellular organismal process relationship: regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032501 ! multicellular organismal process relationship: positively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032501 ! multicellular organismal process relationship: negatively_regulates GO:0032501 ! multicellular organismal process [Term] id: GO:0051245 name: negative regulation of cellular defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai] synonym: "down regulation of cellular defense response" EXACT [] synonym: "down-regulation of cellular defense response" EXACT [] synonym: "downregulation of cellular defense response" EXACT [] synonym: "inhibition of cellular defense response" NARROW [] synonym: "negative regulation of cellular defence response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031348 ! negative regulation of defense response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006968 ! cellular defense response relationship: negatively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019538 ! protein metabolic process relationship: regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process [Term] id: GO:0051249 name: regulation of lymphocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046649 ! lymphocyte activation relationship: regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "down regulation of lymphocyte activation" EXACT [] synonym: "down-regulation of lymphocyte activation" EXACT [] synonym: "downregulation of lymphocyte activation" EXACT [] synonym: "inhibition of lymphocyte activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046649 ! lymphocyte activation relationship: negatively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "activation of lymphocyte activation" NARROW [] synonym: "stimulation of lymphocyte activation" NARROW [] synonym: "up regulation of lymphocyte activation" EXACT [] synonym: "up-regulation of lymphocyte activation" EXACT [] synonym: "upregulation of lymphocyte activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046649 ! lymphocyte activation relationship: positively_regulates GO:0046649 ! lymphocyte activation [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016070 ! RNA metabolic process relationship: regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016070 ! RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process [Term] id: GO:0051255 name: spindle midzone assembly namespace: biological_process def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "spindle midzone biogenesis" EXACT [] synonym: "spindle midzone biosynthesis" EXACT [] synonym: "spindle midzone formation" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0051225 ! spindle assembly [Term] id: GO:0051256 name: mitotic spindle midzone assembly namespace: biological_process def: "The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120] synonym: "mitotic spindle midzone biogenesis" EXACT [] synonym: "mitotic spindle midzone biosynthesis" EXACT [] synonym: "mitotic spindle midzone formation" EXACT [] synonym: "spindle midzone assembly involved in mitosis" EXACT [] synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] synonym: "spindle midzone formation involved in mitosis" EXACT [] is_a: GO:0051255 ! spindle midzone assembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051255 ! spindle midzone assembly intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0000022 ! mitotic spindle elongation relationship: part_of GO:0090307 ! mitotic spindle assembly [Term] id: GO:0051257 name: meiotic spindle midzone assembly namespace: biological_process def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb] synonym: "meiotic spindle midzone biogenesis" EXACT [] synonym: "meiotic spindle midzone biosynthesis" EXACT [] synonym: "meiotic spindle midzone formation" EXACT [] synonym: "spindle midzone assembly involved in meiosis" EXACT [] synonym: "spindle midzone biogenesis involved in meiosis" EXACT [] synonym: "spindle midzone biosynthesis involved in meiosis" EXACT [] synonym: "spindle midzone formation involved in meiosis" EXACT [] is_a: GO:0051255 ! spindle midzone assembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051255 ! spindle midzone assembly intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0051259 name: protein complex oligomerization namespace: biological_process alt_id: GO:0035786 def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929] synonym: "protein multimerization" RELATED [GOC:bf] synonym: "protein oligomer assembly" EXACT [] synonym: "protein oligomer biosynthesis" BROAD [] synonym: "protein oligomer biosynthetic process" BROAD [] synonym: "protein oligomer formation" EXACT [] synonym: "protein oligomerization" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly created_by: rfoulger creation_date: 2011-04-05T09:57:49Z [Term] id: GO:0051260 name: protein homooligomerization namespace: biological_process def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] synonym: "protein homooligomer assembly" EXACT [] synonym: "protein homooligomer biosynthesis" EXACT [] synonym: "protein homooligomer biosynthetic process" EXACT [] synonym: "protein homooligomer formation" EXACT [] synonym: "protein homooligomerization activity" RELATED [] is_a: GO:0051259 ! protein complex oligomerization [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly [Term] id: GO:0051262 name: protein tetramerization namespace: biological_process def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] synonym: "protein tetramer assembly" EXACT [] synonym: "protein tetramer biosynthesis" EXACT [] synonym: "protein tetramer biosynthetic process" EXACT [] synonym: "protein tetramer formation" EXACT [] is_a: GO:0051259 ! protein complex oligomerization [Term] id: GO:0051263 name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine namespace: biological_process def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374] synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT [] synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT [] synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT [] xref: RESID:AA0374 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0051264 name: mono-olein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent mono-olein transacylation" EXACT [] synonym: "MOG transacylation" EXACT [] synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT [] synonym: "mono-oleoylglycerol transacylase activity" EXACT [] synonym: "monoolein transacylation" EXACT [] synonym: "monooleoylglycerol O-acyltransferase activity" EXACT [] synonym: "monooleoylglycerol transacylase activity" EXACT [] is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0051265 name: diolein transacylation activity namespace: molecular_function def: "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929] synonym: "acyl-CoA-independent diolein transacylation" EXACT [] synonym: "dioleoylglycerol O-acyltransferase activity" EXACT [] synonym: "dioleoylglycerol transacylase activity" EXACT [] synonym: "DOG transacylation" EXACT [] is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0051266 name: sirohydrochlorin ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [EC:4.99.1.4, RHEA:24360] synonym: "CysG" RELATED [EC:4.99.1.4] synonym: "Met8P" RELATED [EC:4.99.1.4] synonym: "SirB" RELATED [EC:4.99.1.4] synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4] synonym: "siroheme synthase activity" BROAD [] synonym: "sirohydrochlorin ferro-lyase activity" EXACT [] xref: EC:4.99.1.4 xref: KEGG_REACTION:R02864 xref: MetaCyc:SIROHEME-FERROCHELAT-RXN xref: RHEA:24360 is_a: GO:0004325 ! ferrochelatase activity [Term] id: GO:0051267 name: CP2 mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT [] synonym: "CP2 ethanolamine phosphate transferase activity" EXACT [] synonym: "CP2 EtN-P transferase activity" EXACT [] synonym: "CP2 phosphoethanolamine transferase activity" EXACT [] synonym: "gpi7 activity" RELATED [] is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity [Term] id: GO:0051268 name: alpha-keto amide reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669] is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0051269 name: alpha-keto ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669] xref: EC:1.2 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0051270 name: regulation of cellular component movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "regulation of cell movement" RELATED [] synonym: "regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006928 ! movement of cell or subcellular component relationship: regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051271 name: negative regulation of cellular component movement namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006928 ! movement of cell or subcellular component relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051272 name: positive regulation of cellular component movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006928 ! movement of cell or subcellular component relationship: positively_regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051273 name: beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai] synonym: "beta-glucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0051274 name: beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai] synonym: "beta-glucan anabolism" EXACT [] synonym: "beta-glucan biosynthesis" EXACT [] synonym: "beta-glucan formation" EXACT [] synonym: "beta-glucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0051275 name: beta-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai] synonym: "beta-glucan breakdown" EXACT [] synonym: "beta-glucan catabolism" EXACT [] synonym: "beta-glucan degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] xref: MIPS_funcat:42.10.03 is_a: GO:0006996 ! organelle organization [Term] id: GO:0051278 name: fungal-type cell wall polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu] synonym: "cell wall polysaccharide anabolism" BROAD [] synonym: "cell wall polysaccharide formation" BROAD [] synonym: "cell wall polysaccharide synthesis" BROAD [] synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW [] is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0051279 name: regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] synonym: "regulation of calcium mobilization" EXACT [] synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0051282 ! regulation of sequestering of calcium ion is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051209 ! release of sequestered calcium ion into cytosol relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051280 name: negative regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "negative regulation of calcium mobilization" BROAD [] synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:0051284 ! positive regulation of sequestering of calcium ion is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051281 name: positive regulation of release of sequestered calcium ion into cytosol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] synonym: "positive regulation of calcium mobilization" BROAD [] synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol [Term] id: GO:0051282 name: regulation of sequestering of calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051208 ! sequestering of calcium ion relationship: regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051283 name: negative regulation of sequestering of calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "down regulation of sequestering of calcium ion" EXACT [] synonym: "down-regulation of sequestering of calcium ion" EXACT [] synonym: "downregulation of sequestering of calcium ion" EXACT [] synonym: "inhibition of sequestering of calcium ion" NARROW [] synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051282 ! regulation of sequestering of calcium ion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051208 ! sequestering of calcium ion relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051284 name: positive regulation of sequestering of calcium ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] synonym: "activation of sequestering of calcium ion" NARROW [] synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] synonym: "stimulation of sequestering of calcium ion" NARROW [] synonym: "up regulation of sequestering of calcium ion" EXACT [] synonym: "up-regulation of sequestering of calcium ion" EXACT [] synonym: "upregulation of sequestering of calcium ion" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051282 ! regulation of sequestering of calcium ion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051208 ! sequestering of calcium ion relationship: positively_regulates GO:0051208 ! sequestering of calcium ion [Term] id: GO:0051285 name: cell cortex of cell tip namespace: cellular_component def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai] synonym: "cell cortex of cell end" EXACT [] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0051286 ! cell tip relationship: part_of GO:0051286 ! cell tip [Term] id: GO:0051286 name: cell tip namespace: cellular_component def: "The region at the end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah] comment: Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to the thin ends of elongated cells, such as the ends of axons or dendrites. synonym: "cell end" EXACT [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0051287 name: NAD binding namespace: molecular_function alt_id: GO:0051288 def: "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] subset: goslim_chembl synonym: "NAD or NADH binding" RELATED [GOC:mah] synonym: "NAD+ or NADH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] xref: MIPS_funcat:16.21.07 is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0051289 name: protein homotetramerization namespace: biological_process def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators] synonym: "protein homotetramer assembly" EXACT [] synonym: "protein homotetramer biosynthesis" EXACT [] synonym: "protein homotetramer biosynthetic process" EXACT [] synonym: "protein homotetramer formation" EXACT [] is_a: GO:0051260 ! protein homooligomerization is_a: GO:0051262 ! protein tetramerization [Term] id: GO:0051290 name: protein heterotetramerization namespace: biological_process def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators] synonym: "protein heterotetramer assembly" EXACT [] synonym: "protein heterotetramer biosynthesis" EXACT [] synonym: "protein heterotetramer biosynthetic process" EXACT [] synonym: "protein heterotetramer formation" EXACT [] is_a: GO:0051262 ! protein tetramerization is_a: GO:0051291 ! protein heterooligomerization [Term] id: GO:0051291 name: protein heterooligomerization namespace: biological_process def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] synonym: "protein heterooligomer assembly" EXACT [] synonym: "protein heterooligomer biosynthesis" EXACT [] synonym: "protein heterooligomer biosynthetic process" EXACT [] synonym: "protein heterooligomer formation" EXACT [] is_a: GO:0051259 ! protein complex oligomerization [Term] id: GO:0051292 name: nuclear pore complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah] synonym: "NPC assembly" EXACT [] synonym: "nuclear pore assembly" EXACT [] synonym: "nuclear pore biogenesis" EXACT [] synonym: "nuclear pore biosynthesis" EXACT [] synonym: "nuclear pore complex biogenesis" EXACT [] synonym: "nuclear pore complex biosynthesis" EXACT [] synonym: "nuclear pore complex formation" EXACT [] synonym: "nuclear pore formation" EXACT [] is_a: GO:0006999 ! nuclear pore organization is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0046931 ! pore complex assembly [Term] id: GO:0051293 name: establishment of spindle localization namespace: biological_process def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai] synonym: "establishment of spindle localisation" EXACT [GOC:mah] synonym: "spindle positioning" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051653 ! spindle localization is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051294 name: establishment of spindle orientation namespace: biological_process def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] synonym: "orienting of spindle" EXACT [] synonym: "spindle orientation" EXACT [] is_a: GO:0051293 ! establishment of spindle localization relationship: part_of GO:0030010 ! establishment of cell polarity [Term] id: GO:0051295 name: establishment of meiotic spindle localization namespace: biological_process def: "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai] synonym: "establishment of meiotic spindle localisation" EXACT [GOC:mah] synonym: "meiotic spindle positioning" EXACT [] synonym: "spindle positioning during meiosis" RELATED [] synonym: "spindle positioning involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051293 ! establishment of spindle localization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051293 ! establishment of spindle localization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051296 name: establishment of meiotic spindle orientation namespace: biological_process def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] synonym: "establishment of spindle orientation during meiosis" RELATED [] synonym: "establishment of spindle orientation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "meiotic spindle orientation" EXACT [] synonym: "orienting of meiotic spindle" EXACT [] is_a: GO:0051294 ! establishment of spindle orientation is_a: GO:0051295 ! establishment of meiotic spindle localization intersection_of: GO:0051294 ! establishment of spindle orientation intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051298 name: centrosome duplication namespace: biological_process def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] synonym: "centrosome replication" EXACT [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0051299 name: centrosome separation namespace: biological_process def: "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0051300 name: spindle pole body organization namespace: biological_process alt_id: GO:0051426 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "SPB maturation" RELATED [GOC:vw] synonym: "SPB organization" EXACT [] synonym: "spindle pole body maturation" RELATED [GOC:vw] synonym: "spindle pole body organisation" EXACT [] synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051301 ! cell division relationship: regulates GO:0051301 ! cell division [Term] id: GO:0051303 name: establishment of chromosome localization namespace: biological_process def: "The directed movement of a chromosome to a specific location." [GOC:ai] synonym: "chromosome positioning" EXACT [] synonym: "establishment of chromosome localisation" EXACT [GOC:mah] is_a: GO:0050000 ! chromosome localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051304 name: chromosome separation namespace: biological_process alt_id: GO:0034500 def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243] synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243] synonym: "rDNA separation" NARROW [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0051305 name: chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai] synonym: "chromosome migration to spindle pole" EXACT [] synonym: "chromosome movement" BROAD [] synonym: "chromosome movement to spindle pole" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0022402 ! cell cycle process is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0051306 name: mitotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] synonym: "chromosome separation during mitosis" RELATED [] synonym: "mitotic chromosome separation" RELATED [] synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah] synonym: "sister chromatid separation during mitosis" EXACT [] is_a: GO:0051304 ! chromosome separation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0051307 name: meiotic chromosome separation namespace: biological_process def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai] synonym: "chromosome separation during meiosis" EXACT [] synonym: "meiotic chromosome resolution" EXACT [GOC:mah] is_a: GO:0051304 ! chromosome separation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051304 ! chromosome separation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051308 name: male meiosis chromosome separation namespace: biological_process def: "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai] synonym: "chromosome separation during male meiosis" EXACT [] synonym: "male meiosis chromosome resolution" EXACT [GOC:mah] is_a: GO:0007060 ! male meiosis chromosome segregation is_a: GO:0051307 ! meiotic chromosome separation intersection_of: GO:0051304 ! chromosome separation intersection_of: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0051309 name: female meiosis chromosome separation namespace: biological_process def: "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai] synonym: "chromosome separation during female meiosis" EXACT [] synonym: "female meiosis chromosome resolution" EXACT [GOC:mah] is_a: GO:0016321 ! female meiosis chromosome segregation is_a: GO:0051307 ! meiotic chromosome separation intersection_of: GO:0051304 ! chromosome separation intersection_of: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0051310 name: metaphase plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle." [GOC:ai] synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0051311 name: meiotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] synonym: "metaphase plate congression during meiosis" EXACT [] is_a: GO:0051310 ! metaphase plate congression is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051310 ! metaphase plate congression intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051312 name: chromosome decondensation namespace: biological_process def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0051315 name: attachment of mitotic spindle microtubules to kinetochore namespace: biological_process alt_id: GO:0051314 def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896] comment: This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation) synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] synonym: "attachment of spindle microtubules to mitotic chromosome" EXACT [] synonym: "mitotic bipolar attachment" RELATED [GOC:vw] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0007080 ! mitotic metaphase plate congression relationship: part_of GO:0007080 ! mitotic metaphase plate congression [Term] id: GO:0051316 name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation namespace: biological_process alt_id: GO:0051317 def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to meiotic chromosome" EXACT [] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0051318 name: G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G1_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051319 name: G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G2_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051320 name: S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S-phase" EXACT [] xref: Wikipedia:S_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division [Term] id: GO:0051322 name: anaphase namespace: biological_process def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Anaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051323 name: metaphase namespace: biological_process def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Metaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051324 name: prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Prophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051325 name: interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "karyostasis" EXACT [] synonym: "resting phase" BROAD [] xref: Wikipedia:Interphase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0051326 name: telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase [Term] id: GO:0051327 name: meiotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of meiotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0051328 name: meiotic interphase namespace: biological_process def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of meiotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0051329 name: mitotic interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of mitotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0051330 name: meiotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of meiotic cell cycle" EXACT [] is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051331 name: meiotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of meiotic cell cycle" EXACT [] is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051332 name: meiotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of meiotic cell cycle" EXACT [] synonym: "S-phase of meiotic cell cycle" EXACT [] is_a: GO:0051320 ! S phase relationship: part_of GO:0051328 ! meiotic interphase [Term] id: GO:0051333 name: meiotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process in which the reformation of the nuclear envelope during meiosis occurs." [GOC:ai] is_a: GO:0031468 ! nuclear envelope reassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0031468 ! nuclear envelope reassembly intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0051334 name: meiosis I nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai] is_a: GO:0051333 ! meiotic nuclear envelope reassembly intersection_of: GO:0031468 ! nuclear envelope reassembly intersection_of: part_of GO:0007127 ! meiosis I relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0051335 name: meiosis II nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai] is_a: GO:0051333 ! meiotic nuclear envelope reassembly intersection_of: GO:0031468 ! nuclear envelope reassembly intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016787 ! hydrolase activity relationship: regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051337 name: amitosis namespace: biological_process def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544] synonym: "direct nuclear division" EXACT [] synonym: "Remak nuclear division" EXACT [] is_a: GO:0000280 ! nuclear division [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity [Term] id: GO:0051339 name: regulation of lyase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai] synonym: "lyase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016829 ! lyase activity relationship: regulates GO:0016829 ! lyase activity [Term] id: GO:0051340 name: regulation of ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai] synonym: "ligase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016874 ! ligase activity relationship: regulates GO:0016874 ! ligase activity [Term] id: GO:0051341 name: regulation of oxidoreductase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai] synonym: "oxidoreductase regulator" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016491 ! oxidoreductase activity relationship: regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051342 name: regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW [] synonym: "cAMP phosphodiesterase regulator" NARROW [] synonym: "phosphodiesterase regulator" RELATED [] synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity relationship: regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0051343 name: positive regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW [] synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "cAMP phosphodiesterase activator" NARROW [] synonym: "phosphodiesterase activator" RELATED [] synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity relationship: positively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0051344 name: negative regulation of cyclic-nucleotide phosphodiesterase activity namespace: biological_process def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT [] synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW [] synonym: "cAMP phosphodiesterase inhibitor" NARROW [] synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW [] synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW [] synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] synonym: "phosphodiesterase inhibitor" RELATED [] is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity relationship: negatively_regulates GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016787 ! hydrolase activity relationship: positively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051346 name: negative regulation of hydrolase activity namespace: biological_process def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] synonym: "down regulation of hydrolase activity" EXACT [] synonym: "down-regulation of hydrolase activity" EXACT [] synonym: "downregulation of hydrolase activity" EXACT [] synonym: "hydrolase inhibitor" EXACT [] synonym: "inhibition of hydrolase activity" NARROW [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016787 ! hydrolase activity relationship: negatively_regulates GO:0016787 ! hydrolase activity [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016740 ! transferase activity relationship: positively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity [Term] id: GO:0051349 name: positive regulation of lyase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] synonym: "activation of lyase activity" NARROW [] synonym: "lyase activator" EXACT [] synonym: "stimulation of lyase activity" NARROW [] synonym: "up regulation of lyase activity" EXACT [] synonym: "up-regulation of lyase activity" EXACT [] synonym: "upregulation of lyase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016829 ! lyase activity relationship: positively_regulates GO:0016829 ! lyase activity [Term] id: GO:0051350 name: negative regulation of lyase activity namespace: biological_process def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] synonym: "down regulation of lyase activity" EXACT [] synonym: "down-regulation of lyase activity" EXACT [] synonym: "downregulation of lyase activity" EXACT [] synonym: "inhibition of lyase activity" NARROW [] synonym: "lyase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016829 ! lyase activity relationship: negatively_regulates GO:0016829 ! lyase activity [Term] id: GO:0051351 name: positive regulation of ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] synonym: "activation of ligase activity" NARROW [] synonym: "ligase activator" EXACT [] synonym: "stimulation of ligase activity" NARROW [] synonym: "up regulation of ligase activity" EXACT [] synonym: "up-regulation of ligase activity" EXACT [] synonym: "upregulation of ligase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016874 ! ligase activity relationship: positively_regulates GO:0016874 ! ligase activity [Term] id: GO:0051352 name: negative regulation of ligase activity namespace: biological_process def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] synonym: "down regulation of ligase activity" EXACT [] synonym: "down-regulation of ligase activity" EXACT [] synonym: "downregulation of ligase activity" EXACT [] synonym: "inhibition of ligase activity" NARROW [] synonym: "ligase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016874 ! ligase activity relationship: negatively_regulates GO:0016874 ! ligase activity [Term] id: GO:0051353 name: positive regulation of oxidoreductase activity namespace: biological_process alt_id: GO:0009391 def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] synonym: "activation of oxidoreductase activity" NARROW [] synonym: "oxidoreductase activator" EXACT [] synonym: "ribonucleotide reductase activating enzyme activity" NARROW [] synonym: "stimulation of oxidoreductase activity" NARROW [] synonym: "up regulation of oxidoreductase activity" EXACT [] synonym: "up-regulation of oxidoreductase activity" EXACT [] synonym: "upregulation of oxidoreductase activity" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016491 ! oxidoreductase activity relationship: positively_regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051354 name: negative regulation of oxidoreductase activity namespace: biological_process def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] synonym: "down regulation of oxidoreductase activity" EXACT [] synonym: "down-regulation of oxidoreductase activity" EXACT [] synonym: "downregulation of oxidoreductase activity" EXACT [] synonym: "inhibition of oxidoreductase activity" NARROW [] synonym: "oxidoreductase inhibitor" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016491 ! oxidoreductase activity relationship: negatively_regulates GO:0016491 ! oxidoreductase activity [Term] id: GO:0051355 name: proprioception involved in equilibrioception namespace: biological_process def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by proprioception" EXACT [] synonym: "perception of orientation with respect to gravity by proprioception" EXACT [] synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0019230 ! proprioception intersection_of: GO:0019230 ! proprioception intersection_of: part_of GO:0050957 ! equilibrioception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0051356 name: visual perception involved in equilibrioception namespace: biological_process def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] synonym: "equilibrioception by visual perception" NARROW [] synonym: "perception of orientation with respect to gravity by visual perception" EXACT [] synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb] is_a: GO:0007601 ! visual perception intersection_of: GO:0007601 ! visual perception intersection_of: part_of GO:0050957 ! equilibrioception relationship: part_of GO:0050957 ! equilibrioception [Term] id: GO:0051357 name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one namespace: biological_process def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377] comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'. synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] xref: RESID:AA0377 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051358 name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine namespace: biological_process def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] xref: RESID:AA0378 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051359 name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0379 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018206 ! peptidyl-methionine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051360 name: peptide cross-linking via L-asparagine 5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0380 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051361 name: peptide cross-linking via L-lysine 5-imidazolinone glycine namespace: biological_process def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] xref: RESID:AA0381 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051362 name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0382 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0051363 name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein namespace: biological_process def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383] comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. xref: RESID:AA0383 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0051364 name: N-terminal peptidyl-proline N-formylation namespace: biological_process def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384] xref: RESID:AA0384 is_a: GO:0018004 ! N-terminal protein formylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0051365 name: cellular response to potassium ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm] synonym: "cellular response to K+ ion deprivation" EXACT [] synonym: "cellular response to K+ ion starvation" EXACT [] synonym: "cellular response to potassium ion deprivation" EXACT [] synonym: "cellular response to potassium starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0051366 name: protein decanoylation namespace: biological_process def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg] synonym: "protein amino acid decanoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0051367 name: peptidyl-serine decanoylation namespace: biological_process def: "The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385] xref: RESID:AA0385 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0051366 ! protein decanoylation [Term] id: GO:0051368 name: peptidyl-threonine octanoylation namespace: biological_process def: "The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] xref: RESID:AA0386 is_a: GO:0018190 ! protein octanoylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0051369 name: peptidyl-threonine decanoylation namespace: biological_process def: "The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] xref: RESID:AA0387 is_a: GO:0018210 ! peptidyl-threonine modification is_a: GO:0051366 ! protein decanoylation [Term] id: GO:0051370 name: obsolete ZASP binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT [] synonym: "ZASP binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0051371 name: muscle alpha-actinin binding namespace: molecular_function def: "Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] synonym: "alpha-actinin 2 binding" NARROW [] synonym: "alpha-actinin 3 binding" NARROW [] is_a: GO:0051393 ! alpha-actinin binding [Term] id: GO:0051373 name: FATZ binding namespace: molecular_function alt_id: GO:0051374 alt_id: GO:0051375 alt_id: GO:0051376 def: "Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] synonym: "calsarcin 1 binding" EXACT [] synonym: "calsarcin 2 binding" EXACT [] synonym: "calsarcin 3 binding" EXACT [] synonym: "calsarcin binding" EXACT [] synonym: "FATZ 1 binding" EXACT [] synonym: "FATZ 2 binding" EXACT [] synonym: "FATZ 3 binding" EXACT [] synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0051377 name: mannose-ethanolamine phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136] synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT [] synonym: "ethanolamine phosphate transferase activity" BROAD [] synonym: "EtN-P transferase activity" EXACT [] synonym: "phosphoethanolamine transferase activity" BROAD [] xref: Reactome:R-HSA-162798 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0051378 name: serotonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043176 ! amine binding is_a: GO:0070405 ! ammonium ion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0051379 name: epinephrine binding namespace: molecular_function def: "Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline binding" EXACT [] is_a: GO:1901338 ! catecholamine binding [Term] id: GO:0051380 name: norepinephrine binding namespace: molecular_function def: "Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] is_a: GO:1901338 ! catecholamine binding [Term] id: GO:0051381 name: histamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0070405 ! ammonium ion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0051382 name: kinetochore assembly namespace: biological_process alt_id: GO:0000069 def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai] synonym: "centromere and kinetochore complex maturation" NARROW [] synonym: "centromere/kinetochore complex maturation" NARROW [] synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore formation" RELATED [] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0051383 ! kinetochore organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0051383 name: kinetochore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "kinetochore organisation" EXACT [] synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah] xref: MIPS_funcat:42.10.04 is_a: GO:0051276 ! chromosome organization [Term] id: GO:0051384 name: response to glucocorticoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos] is_a: GO:0031960 ! response to corticosteroid [Term] id: GO:0051385 name: response to mineralocorticoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123] synonym: "response to mineralocorticoid stimulus" EXACT [GOC:dos] is_a: GO:0031960 ! response to corticosteroid [Term] id: GO:0051386 name: regulation of neurotrophin TRK receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] synonym: "regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "regulation of NGF receptor signaling pathway" EXACT [] synonym: "regulation of NGF receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway relationship: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway [Term] id: GO:0051387 name: negative regulation of neurotrophin TRK receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "negative regulation of NGF receptor signaling pathway" EXACT [] synonym: "negative regulation of NGF receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway relationship: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway [Term] id: GO:0051388 name: positive regulation of neurotrophin TRK receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] synonym: "activation of nerve growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT [] synonym: "positive regulation of NGF receptor signaling pathway" EXACT [] synonym: "positive regulation of NGF receptor signalling pathway" EXACT [] synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway relationship: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway [Term] id: GO:0051389 name: inactivation of MAPKK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK)." [GOC:ai] synonym: "inactivation of MAP kinase kinase activity" EXACT [] synonym: "termination of MAP kinase kinase activity" EXACT [] synonym: "termination of MAPKK activity" EXACT [] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043409 ! negative regulation of MAPK cascade relationship: negatively_regulates GO:0004708 ! MAP kinase kinase activity [Term] id: GO:0051390 name: inactivation of MAPKKK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK)." [GOC:ai] synonym: "inactivation of MAP kinase kinase kinase activity" EXACT [] synonym: "termination of MAP kinase kinase kinase activity" EXACT [] synonym: "termination of MAPKKK activity" EXACT [] is_a: GO:0043405 ! regulation of MAP kinase activity is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity relationship: negatively_regulates GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0051391 name: tRNA acetylation namespace: biological_process def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] is_a: GO:0006400 ! tRNA modification is_a: GO:1990884 ! RNA acetylation [Term] id: GO:0051392 name: tRNA N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780] synonym: "tRNA cytidine N-acetyltransferase activity" EXACT [] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0051393 name: alpha-actinin binding namespace: molecular_function alt_id: GO:0051372 def: "Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] synonym: "alpha-actinin 1 binding" NARROW [] synonym: "alpha-actinin 4 binding" NARROW [] synonym: "nonmuscle alpha-actinin binding" NARROW [] is_a: GO:0042805 ! actinin binding [Term] id: GO:0051394 name: regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] synonym: "regulation of NGF receptor activity" EXACT [] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010465 ! nerve growth factor receptor activity relationship: regulates GO:0010465 ! nerve growth factor receptor activity [Term] id: GO:0051395 name: negative regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] synonym: "down regulation of nerve growth factor receptor activity" EXACT [] synonym: "down-regulation of nerve growth factor receptor activity" EXACT [] synonym: "downregulation of nerve growth factor receptor activity" EXACT [] synonym: "inhibition of nerve growth factor receptor activity" NARROW [] synonym: "negative regulation of NGF receptor activity" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0051394 ! regulation of nerve growth factor receptor activity is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010465 ! nerve growth factor receptor activity relationship: negatively_regulates GO:0010465 ! nerve growth factor receptor activity [Term] id: GO:0051396 name: positive regulation of nerve growth factor receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] synonym: "activation of nerve growth factor receptor activity" NARROW [] synonym: "positive regulation of NGF receptor activity" EXACT [] synonym: "stimulation of nerve growth factor receptor activity" NARROW [] synonym: "up regulation of nerve growth factor receptor activity" EXACT [] synonym: "up-regulation of nerve growth factor receptor activity" EXACT [] synonym: "upregulation of nerve growth factor receptor activity" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0051394 ! regulation of nerve growth factor receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010465 ! nerve growth factor receptor activity relationship: positively_regulates GO:0010465 ! nerve growth factor receptor activity [Term] id: GO:0051397 name: obsolete N-terminal basic amino acid aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "N-terminal basic amino acid aminopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051398 name: obsolete N-terminal lysine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] comment: This term was made obsolete because it represents a gene product. synonym: "lysine aminopeptidase activity" BROAD [] synonym: "lysyl aminopeptidase activity" BROAD [] synonym: "N-terminal lysine aminopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051399 name: obsolete N-terminal arginine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] comment: This term was made obsolete because it represents a gene product. synonym: "arginine aminopeptidase activity" BROAD [] synonym: "argininyl aminopeptidase activity" BROAD [] synonym: "N-terminal arginine aminopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0051400 name: BH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] subset: goslim_chembl synonym: "Bcl-2 homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051401 name: CH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021] synonym: "calponin homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051402 name: neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron apoptosis" NARROW [] synonym: "neuron programmed cell death by apoptosis" EXACT [] synonym: "neuronal cell apoptosis" EXACT [] synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptotic process is_a: GO:0070997 ! neuron death [Term] id: GO:0051403 name: stress-activated MAPK cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] synonym: "MAPK11 cascade" NARROW [GOC:add] synonym: "MAPK12 cascade" NARROW [GOC:add] synonym: "MAPK13 cascade" NARROW [GOC:add] synonym: "MAPK14 cascade" NARROW [GOC:add] synonym: "p38 cascade" NARROW [GOC:add] synonym: "p38 MAPK signaling" NARROW [] synonym: "p38 MAPK signalling" NARROW [] synonym: "SAPK cascade" BROAD [GOC:add] synonym: "stress-activated MAPK signaling pathway" EXACT [] synonym: "stress-activated MAPK signalling pathway" EXACT [] synonym: "stress-activated MAPKKK cascade" EXACT [] synonym: "stress-activated MAPKKK signaling pathway" EXACT [] synonym: "stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0000165 ! MAPK cascade is_a: GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0051404 name: obsolete clostripain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] synonym: "clostridiopeptidase B activity" EXACT [] synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] synonym: "clostripain activity" EXACT [] xref: EC:3.4.22.8 is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0051405 name: obsolete microbial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3] comment: This term was made obsolete because it represents a gene product. synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3] synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3] synonym: "azocollase activity" EXACT [EC:3.4.24.3] synonym: "clostridiopeptidase A activity" EXACT [] synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3] synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3] synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3] synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3] synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3] synonym: "collagen protease activity" EXACT [EC:3.4.24.3] synonym: "collagenase 1 activity" EXACT [] synonym: "collagenase A activity" EXACT [] synonym: "collagenase I activity" EXACT [EC:3.4.24.3] synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3] synonym: "kollaza" RELATED [EC:3.4.24.3] synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3] synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3] synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "microbial collagenase activity" EXACT [] synonym: "nucleolysin" RELATED [EC:3.4.24.3] synonym: "soycollagestin" RELATED [EC:3.4.24.3] xref: EC:3.4.24.3 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0051407 name: glycerone phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai] synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0051408 name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0009670 ! triose-phosphate:phosphate antiporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0051409 name: response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705] is_a: GO:0006950 ! response to stress [Term] id: GO:0051410 name: detoxification of nitrogen compound namespace: biological_process def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] synonym: "detoxification of nitrogenous compound" EXACT [] synonym: "nitric oxide (NO) detoxification" NARROW [] is_a: GO:0098754 ! detoxification relationship: part_of GO:1901698 ! response to nitrogen compound [Term] id: GO:0051411 name: obsolete ALP binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "actinin-associated LIM protein binding" EXACT [] synonym: "ALP binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0051412 name: response to corticosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347] synonym: "response to corticosterone stimulus" EXACT [GOC:dos] is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0051413 name: response to cortisone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544, PMID:11276391] synonym: "response to cortisone stimulus" EXACT [GOC:dos] is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0051414 name: response to cortisol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391] synonym: "response to cortisol stimulus" EXACT [GOC:dos] synonym: "response to hydrocortisone stimulus" EXACT [] is_a: GO:0042493 ! response to drug is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone [Term] id: GO:0051415 name: microtubule nucleation by interphase microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] synonym: "interphase microtubule nucleation by interphase microtubule organizing center" EXACT [] synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center [Term] id: GO:0051416 name: obsolete myotilin binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "myotilin binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0051417 name: microtubule nucleation by spindle pole body namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai] synonym: "microtubule nucleation by SPB" EXACT [] synonym: "SPB-mediated microtubule nucleation" EXACT [] synonym: "spindle pole body-mediated microtubule nucleation" EXACT [] is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center [Term] id: GO:0051418 name: microtubule nucleation by microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] synonym: "microtubule nucleation by microtubule organising centre" EXACT [] synonym: "microtubule nucleation by MTOC" EXACT [] synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] synonym: "MTOC-mediated microtubule nucleation" EXACT [] is_a: GO:0007020 ! microtubule nucleation [Term] id: GO:0051419 name: obsolete nebulin binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "nebulin binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0051420 name: obsolete nebulette binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "nebulette binding" EXACT [] is_obsolete: true replaced_by: GO:0008092 [Term] id: GO:0051421 name: regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "endo-1,4-beta-xylanase regulator" RELATED [] synonym: "xylanase regulator" RELATED [] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031176 ! endo-1,4-beta-xylanase activity relationship: regulates GO:0031176 ! endo-1,4-beta-xylanase activity [Term] id: GO:0051422 name: negative regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "endo-1,4-beta-xylanase inhibitor" RELATED [] synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW [] synonym: "xylanase inhibitor" RELATED [] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity relationship: negatively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity [Term] id: GO:0051423 name: positive regulation of endo-1,4-beta-xylanase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] synonym: "activation of endo-1,4-beta-xylanase activity" NARROW [] synonym: "endo-1,4-beta-xylanase activator" RELATED [] synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW [] synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT [] synonym: "xylanase activator" RELATED [] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity relationship: positively_regulates GO:0031176 ! endo-1,4-beta-xylanase activity [Term] id: GO:0051424 name: corticotropin-releasing hormone binding namespace: molecular_function alt_id: GO:0017047 def: "Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com] synonym: "corticoliberin binding" EXACT [] synonym: "corticotropin-releasing factor binding" EXACT [] synonym: "CRF binding" EXACT [GOC:bf] synonym: "CRH binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding is_a: GO:0042165 ! neurotransmitter binding [Term] id: GO:0051425 name: PTB domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411] synonym: "phosphotyrosine-interacting domain binding" EXACT [] synonym: "PID binding" BROAD [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051427 name: hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for hormones." [GOC:ai] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0051428 name: peptide hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for peptide hormones." [GOC:ai] subset: goslim_chembl synonym: "polypeptide hormone receptor binding" EXACT [] is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0051429 name: corticotropin-releasing hormone receptor binding namespace: molecular_function alt_id: GO:0031742 def: "Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai] synonym: "corticotropin releasing factor receptor binding" EXACT [] synonym: "corticotropin releasing factor receptor ligand" NARROW [] synonym: "corticotropin-releasing factor receptor binding" EXACT [GOC:bf] synonym: "CRF receptor binding" EXACT [GOC:bf] synonym: "CRH receptor binding" EXACT [GOC:bf] synonym: "CRHR binding" EXACT [GOC:bf] is_a: GO:0051428 ! peptide hormone receptor binding is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0051430 name: corticotropin-releasing hormone receptor 1 binding namespace: molecular_function alt_id: GO:0031743 def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857] synonym: "CRHR1 binding" EXACT [] synonym: "type 1 corticotropin releasing factor receptor binding" EXACT [] synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW [] synonym: "type 1 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding [Term] id: GO:0051431 name: corticotropin-releasing hormone receptor 2 binding namespace: molecular_function alt_id: GO:0031744 def: "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857] synonym: "CRHR2 binding" EXACT [] synonym: "type 2 corticotropin releasing factor receptor binding" EXACT [] synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW [] synonym: "type 2 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding [Term] id: GO:0051432 name: BH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051433 name: BH2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051434 name: BH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] subset: goslim_chembl is_a: GO:0051400 ! BH domain binding is_a: GO:0070513 ! death domain binding [Term] id: GO:0051435 name: BH4 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063] is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051436 name: obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15196 synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "APC inhibition during mitotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic anaphase promoting complex inhibition" NARROW [] synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] synonym: "mitotic APC inhibition" NARROW [] synonym: "mitotic APC inhibitor" NARROW [] synonym: "mitotic SCF complex inhibitor" NARROW [] synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0051437 name: obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition namespace: biological_process def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition." [GOC:ai, GOC:tb] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15196 synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic SCF complex activator" NARROW [] synonym: "mitotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] is_obsolete: true [Term] id: GO:0051438 name: regulation of ubiquitin-protein transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] synonym: "anaphase-promoting complex regulator" NARROW [] synonym: "APC regulator" NARROW [] synonym: "regulation of ubiquitin transferase activity" EXACT [GOC:tb] synonym: "SCF complex regulator" NARROW [] synonym: "ubiquitin transferase regulator" RELATED [] synonym: "ubiquitin-protein transferase regulator" RELATED [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: regulates GO:0004842 ! ubiquitin-protein transferase activity [Term] id: GO:0051439 name: obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai] comment: false synonym: "mitotic anaphase-promoting complex regulator" NARROW [] synonym: "mitotic APC regulator" NARROW [] synonym: "mitotic SCF complex regulator" NARROW [] synonym: "mitotic ubiquitin ligase regulator" RELATED [] synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0051440 name: obsolete regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15196 synonym: "meiotic anaphase-promoting complex regulator" NARROW [] synonym: "meiotic APC regulator" NARROW [] synonym: "meiotic SCF complex regulator" NARROW [] synonym: "meiotic ubiquitin ligase regulator" RELATED [] synonym: "meiotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0051441 name: obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process alt_id: GO:0051487 def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:mah, GOC:tb, PMID:10871297] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15196 synonym: "activation of anaphase-promoting complex activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "activation of anaphase-promoting complex activity involved in meiotic cell cycle" NARROW [] synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" RELATED [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" RELATED [] synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" RELATED [] synonym: "anaphase promoting complex activation during meiotic cell cycle" RELATED [] synonym: "anaphase-promoting complex activation during meiotic cell cycle" RELATED [] synonym: "APC activation during meiotic cell cycle" RELATED [] synonym: "meiotic anaphase promoting complex activation" RELATED [] synonym: "meiotic anaphase promoting complex activator" NARROW [] synonym: "meiotic anaphase-promoting complex activator" NARROW [] synonym: "meiotic APC activation" EXACT [] synonym: "meiotic APC activator" NARROW [] synonym: "meiotic SCF complex activator" NARROW [] synonym: "meiotic ubiquitin ligase activator" NARROW [] synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] synonym: "positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] is_obsolete: true [Term] id: GO:0051442 name: obsolete negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15196 synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW [] synonym: "APC inhibition during meiotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW [] synonym: "meiotic anaphase promoting complex inhibition" NARROW [] synonym: "meiotic anaphase promoting complex inhibitor" NARROW [] synonym: "meiotic anaphase-promoting complex inhibition" NARROW [] synonym: "meiotic anaphase-promoting complex inhibitor" NARROW [] synonym: "meiotic APC inhibition" NARROW [] synonym: "meiotic APC inhibitor" NARROW [] synonym: "meiotic SCF complex inhibitor" NARROW [] synonym: "meiotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0051443 name: positive regulation of ubiquitin-protein transferase activity namespace: biological_process def: "Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb] synonym: "activation of ubiquitin transferase activity" NARROW [] synonym: "anaphase promoting complex activator" NARROW [] synonym: "anaphase-promoting complex activator" NARROW [] synonym: "APC activation" NARROW [] synonym: "APC activator" NARROW [] synonym: "positive regulation of ubiquitin transferase activity" EXACT [GOC:tb] synonym: "SCF complex activator" NARROW [] synonym: "stimulation of ubiquitin transferase activity" NARROW [] synonym: "ubiquitin transferase activator" NARROW [] synonym: "up regulation of ubiquitin ligase activity" RELATED [] synonym: "up-regulation of ubiquitin transferase activity" EXACT [] synonym: "upregulation of ubiquitin transferase activity" EXACT [] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity [Term] id: GO:0051444 name: negative regulation of ubiquitin-protein transferase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition" NARROW [] synonym: "anaphase promoting complex inhibitor" NARROW [] synonym: "anaphase-promoting complex inhibition" NARROW [] synonym: "anaphase-promoting complex inhibitor" NARROW [] synonym: "APC inhibition" NARROW [] synonym: "APC inhibitor" NARROW [] synonym: "down regulation of ubiquitin transferase activity" EXACT [] synonym: "down-regulation of ubiquitin transferase activity" EXACT [] synonym: "downregulation of ubiquitin transferase activity" EXACT [] synonym: "inhibition of ubiquitin transferase activity" NARROW [] synonym: "negative regulation of ubiquitin transferase activity" EXACT [GOC:tb] synonym: "SCF complex inhibitor" NARROW [] synonym: "ubiquitin transferase inhibitor" NARROW [] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051321 ! meiotic cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle relationship: positively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle [Term] id: GO:0051448 name: gonadotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:pr, PMID:1984190] synonym: "GnRH binding" EXACT [] synonym: "gonadotrophin releasing hormone binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0051449 name: thyrotropin-releasing hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai] synonym: "thyrotropin releasing hormone binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding [Term] id: GO:0051450 name: myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0051451 name: myoblast migration namespace: biological_process def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration [Term] id: GO:0051452 name: intracellular pH reduction namespace: biological_process def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] synonym: "cell pH reduction" EXACT [] synonym: "cellular acidification" EXACT [] synonym: "intracellular acidification" RELATED [] synonym: "reduction of cellular pH" EXACT [] synonym: "reduction of pH in cell" EXACT [] is_a: GO:0045851 ! pH reduction is_a: GO:0051453 ! regulation of intracellular pH [Term] id: GO:0051453 name: regulation of intracellular pH namespace: biological_process def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb] synonym: "cell pH regulation" EXACT [] synonym: "cellular pH regulation" EXACT [] synonym: "pH regulation in cell" EXACT [] synonym: "regulation of cell pH" EXACT [] is_a: GO:0030641 ! regulation of cellular pH [Term] id: GO:0051454 name: intracellular pH elevation namespace: biological_process def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] synonym: "cell pH elevation" EXACT [] synonym: "cellular alkalinization" EXACT [] synonym: "elevation of cellular pH" EXACT [] synonym: "intracellular alkalinization" EXACT [] synonym: "pH elevation in cell" EXACT [] is_a: GO:0045852 ! pH elevation is_a: GO:0051453 ! regulation of intracellular pH [Term] id: GO:0051455 name: monopolar spindle attachment to meiosis I kinetochore namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb] synonym: "monopolar attachment" EXACT [] synonym: "sister kinetochore mono-orientation" EXACT [] is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0045143 ! homologous chromosome segregation relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0051456 name: attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during meiosis II" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in meiosis II" RELATED [GOC:dph, GOC:tb] synonym: "meiotic bipolar attachment" RELATED [GOC:vw] is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0045144 ! meiotic sister chromatid segregation relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0051457 name: maintenance of protein location in nucleus namespace: biological_process def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] synonym: "maintenance of nuclear protein localization" EXACT [] synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein location in cell nucleus" EXACT [] synonym: "nuclear protein retention" NARROW [] synonym: "nuclear protein sequestering" NARROW [] synonym: "nuclear protein sequestration" NARROW [] synonym: "protein retention in nucleus" NARROW [] synonym: "protein sequestration in nucleus" NARROW [] synonym: "protein storage in nucleus" NARROW [] synonym: "protein-nuclear retention" NARROW [] synonym: "sequestration of protein in nucleus" NARROW [] synonym: "storage of protein in nucleus" NARROW [] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005634 ! nucleus relationship: occurs_in GO:0005634 ! nucleus relationship: part_of GO:0034504 ! protein localization to nucleus [Term] id: GO:0051458 name: corticotropin secretion namespace: biological_process def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914] synonym: "ACTH secretion" EXACT [] synonym: "adrenocorticotropic hormone secretion" EXACT [] synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb] synonym: "adrenotropic hormone secretion" EXACT [] synonym: "adrenotropin secretion" EXACT [] synonym: "corticotropic hormone secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0051459 name: regulation of corticotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph] synonym: "regulation of ACTH secretion" EXACT [] synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph] synonym: "regulation of adrenocorticotropin secretion" EXACT [] synonym: "regulation of adrenotropin hormone secretion" EXACT [] synonym: "regulation of adrenotropin secretion" EXACT [] synonym: "regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051458 ! corticotropin secretion relationship: regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051460 name: negative regulation of corticotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai] synonym: "down regulation of adrenocorticotropin secretion" EXACT [] synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] synonym: "downregulation of adrenocorticotropin secretion" EXACT [] synonym: "inhibition of adrenocorticotropin secretion" NARROW [] synonym: "negative regulation of ACTH secretion" EXACT [] synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenotropin secretion" EXACT [] synonym: "negative regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051458 ! corticotropin secretion relationship: negatively_regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051461 name: positive regulation of corticotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai] synonym: "activation of adrenocorticotropin secretion" NARROW [] synonym: "positive regulation of ACTH secretion" EXACT [] synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenotropin secretion" EXACT [] synonym: "positive regulation of corticotropic hormone secretion" EXACT [] synonym: "stimulation of adrenocorticotropin secretion" NARROW [] synonym: "up regulation of adrenocorticotropin secretion" EXACT [] synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] synonym: "upregulation of adrenocorticotropin secretion" EXACT [] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051458 ! corticotropin secretion relationship: positively_regulates GO:0051458 ! corticotropin secretion [Term] id: GO:0051462 name: regulation of cortisol secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] is_a: GO:2000849 ! regulation of glucocorticoid secretion is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043400 ! cortisol secretion relationship: regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051463 name: negative regulation of cortisol secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] synonym: "down regulation of cortisol secretion" EXACT [] synonym: "down-regulation of cortisol secretion" EXACT [] synonym: "downregulation of cortisol secretion" EXACT [] synonym: "inhibition of cortisol secretion" NARROW [] is_a: GO:0051462 ! regulation of cortisol secretion is_a: GO:2000850 ! negative regulation of glucocorticoid secretion is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043400 ! cortisol secretion relationship: negatively_regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051464 name: positive regulation of cortisol secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] synonym: "activation of cortisol secretion" NARROW [] synonym: "stimulation of cortisol secretion" NARROW [] synonym: "up regulation of cortisol secretion" EXACT [] synonym: "up-regulation of cortisol secretion" EXACT [] synonym: "upregulation of cortisol secretion" EXACT [] is_a: GO:0051462 ! regulation of cortisol secretion is_a: GO:2000851 ! positive regulation of glucocorticoid secretion is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043400 ! cortisol secretion relationship: positively_regulates GO:0043400 ! cortisol secretion [Term] id: GO:0051465 name: negative regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai] synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW [] synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "negative regulation of CRF secretion" EXACT [] synonym: "negative regulation of CRH secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0051466 name: positive regulation of corticotropin-releasing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai] synonym: "activation of corticotropin-releasing hormone secretion" NARROW [] synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "positive regulation of CRF secretion" EXACT [] synonym: "positive regulation of CRH secretion" EXACT [] synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW [] synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion [Term] id: GO:0051467 name: detection of steroid hormone stimulus namespace: biological_process def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0048545 ! response to steroid hormone [Term] id: GO:0051468 name: detection of glucocorticoid hormone stimulus namespace: biological_process def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai] is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0051467 ! detection of steroid hormone stimulus [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process alt_id: GO:0042146 def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion is_a: GO:0097576 ! vacuole fusion [Term] id: GO:0051470 name: ectoine transport namespace: biological_process def: "The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0051472 name: glucosylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] synonym: "glucosylglycerol metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0051473 name: glucosylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] synonym: "glucosylglycerol anabolism" EXACT [] synonym: "glucosylglycerol biosynthesis" EXACT [] synonym: "glucosylglycerol formation" EXACT [] synonym: "glucosylglycerol synthesis" EXACT [] is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0051472 ! glucosylglycerol metabolic process [Term] id: GO:0051474 name: glucosylglycerol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0051475 ! glucosylglycerol transport [Term] id: GO:0051475 name: glucosylglycerol transport namespace: biological_process def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0051476 name: mannosylglycerate transport namespace: biological_process def: "The directed movement of mannosylglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901656 ! glycoside transport [Term] id: GO:0051477 name: mannosylglycerate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a mannosylglycerate from one side of a membrane to the other." [GOC:ai, PMID:15034926] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0051476 ! mannosylglycerate transport [Term] id: GO:0051478 name: mannosylglycerate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374] synonym: "mannosylglycerate metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0051479 name: mannosylglycerate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai] synonym: "mannosylglycerate anabolism" EXACT [] synonym: "mannosylglycerate biosynthesis" EXACT [] synonym: "mannosylglycerate formation" EXACT [] synonym: "mannosylglycerate synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0051478 ! mannosylglycerate metabolic process [Term] id: GO:0051480 name: regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph] synonym: "calcium ion homeostasis in cytoplasm" BROAD [] synonym: "calcium ion homeostasis in cytosol" EXACT [] synonym: "cytoplasmic calcium ion concentration regulation" BROAD [] synonym: "cytoplasmic calcium ion homeostasis" BROAD [] synonym: "cytosolic calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in cytoplasm" BROAD [] synonym: "regulation of calcium ion concentration in cytosol" EXACT [] synonym: "regulation of cytoplasmic calcium ion concentration" BROAD [] synonym: "regulation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0051481 name: negative regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration reduction" BROAD [] synonym: "cytosolic calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in cytoplasm" BROAD [] synonym: "reduction of calcium ion concentration in cytosol" EXACT [] synonym: "reduction of cytoplasmic calcium ion concentration" BROAD [] synonym: "reduction of cytosolic calcium ion concentration" EXACT [] is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0051482 name: positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling] synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] synonym: "elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger" EXACT [GOC:signaling] synonym: "elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT [] synonym: "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT [] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: part_of GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway relationship: part_of GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway [Term] id: GO:0051483 name: terpenoid biosynthetic process, mevalonate-independent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] synonym: "mevalonate-independent terpene biosynthesis" NARROW [] synonym: "mevalonate-independent terpene biosynthetic process" NARROW [] synonym: "mevalonate-independent terpenoid biosynthesis" EXACT [] synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT [] synonym: "terpene biosynthesis, mevalonate-independent" NARROW [] synonym: "terpene biosynthetic process, mevalonate-independent" NARROW [] synonym: "terpenoid anabolism, mevalonate-independent" EXACT [] synonym: "terpenoid formation, mevalonate-independent" EXACT [] synonym: "terpenoid synthesis, mevalonate-independent" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0051484 name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" RELATED [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process" RELATED [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" RELATED [] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" RELATED [] synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" RELATED [] xref: MetaCyc:NONMEVIPP-PWY is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway intersection_of: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway intersection_of: part_of GO:0016114 ! terpenoid biosynthetic process relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent [Term] id: GO:0051485 name: terpenoid biosynthetic process, mevalonate-dependent namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] synonym: "terpene biosynthesis, mevalonate-dependent" NARROW [] synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW [] synonym: "terpenoid anabolism, mevalonate-dependent" EXACT [] synonym: "terpenoid formation, mevalonate-dependent" EXACT [] synonym: "terpenoid synthesis, mevalonate-dependent" EXACT [] is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0051486 name: isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" RELATED [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" RELATED [] synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" RELATED [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" RELATED [] is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway intersection_of: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway intersection_of: part_of GO:0016114 ! terpenoid biosynthetic process relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent [Term] id: GO:0051489 name: regulation of filopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] synonym: "regulation of filopodia biosynthesis" EXACT [] synonym: "regulation of filopodia formation" EXACT [] synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046847 ! filopodium assembly relationship: regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051490 name: negative regulation of filopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] synonym: "down regulation of filopodium formation" EXACT [] synonym: "down-regulation of filopodium formation" EXACT [] synonym: "downregulation of filopodium formation" EXACT [] synonym: "inhibition of filopodium formation" NARROW [] synonym: "negative regulation of filopodia biosynthesis" EXACT [] synonym: "negative regulation of filopodia formation" EXACT [] synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0051489 ! regulation of filopodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046847 ! filopodium assembly relationship: negatively_regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051491 name: positive regulation of filopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of filopodium formation" NARROW [] synonym: "positive regulation of filopodia biosynthesis" EXACT [] synonym: "positive regulation of filopodia formation" EXACT [] synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of filopodium formation" NARROW [] synonym: "up regulation of filopodium formation" EXACT [] synonym: "up-regulation of filopodium formation" EXACT [] synonym: "upregulation of filopodium formation" EXACT [] is_a: GO:0051489 ! regulation of filopodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046847 ! filopodium assembly relationship: positively_regulates GO:0046847 ! filopodium assembly [Term] id: GO:0051492 name: regulation of stress fiber assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "regulation of stress fibre biosynthesis" RELATED [] synonym: "regulation of stress fibre formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0110020 ! regulation of actomyosin structure organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043149 ! stress fiber assembly relationship: regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007010 ! cytoskeleton organization relationship: regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007010 ! cytoskeleton organization relationship: negatively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007010 ! cytoskeleton organization relationship: positively_regulates GO:0007010 ! cytoskeleton organization [Term] id: GO:0051496 name: positive regulation of stress fiber assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "activation of stress fiber formation" NARROW [] synonym: "positive regulation of stress fibre biosynthesis" RELATED [] synonym: "positive regulation of stress fibre formation" RELATED [] synonym: "stimulation of stress fiber formation" NARROW [] synonym: "up regulation of stress fiber formation" RELATED [] synonym: "up-regulation of stress fiber formation" EXACT [] synonym: "upregulation of stress fiber formation" RELATED [] is_a: GO:0032233 ! positive regulation of actin filament bundle assembly is_a: GO:0051492 ! regulation of stress fiber assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043149 ! stress fiber assembly relationship: positively_regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051497 name: negative regulation of stress fiber assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] synonym: "down regulation of stress fiber formation" RELATED [] synonym: "down-regulation of stress fiber formation" EXACT [] synonym: "downregulation of stress fiber formation" RELATED [] synonym: "inhibition of stress fiber formation" NARROW [] synonym: "negative regulation of stress fibre biosynthesis" RELATED [] synonym: "negative regulation of stress fibre formation" RELATED [] is_a: GO:0032232 ! negative regulation of actin filament bundle assembly is_a: GO:0051492 ! regulation of stress fiber assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043149 ! stress fiber assembly relationship: negatively_regulates GO:0043149 ! stress fiber assembly [Term] id: GO:0051498 name: syn-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate." [MetaCyc:RXN-8528] synonym: "diterpene cyclase activity" BROAD [] xref: EC:5.5.1.14 xref: MetaCyc:RXN-8528 xref: RHEA:25524 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0051499 name: D-aminoacyl-tRNA deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] xref: EC:3.1.1.96 xref: MetaCyc:RXN-15041 is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0051500 name: D-tyrosyl-tRNA(Tyr) deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667] is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity [Term] id: GO:0051501 name: diterpene phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, http://www.onelook.com, ISBN:0721662544] synonym: "diterpene phytoalexin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0051502 name: diterpene phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai] synonym: "diterpene phytoalexin anabolism" EXACT [] synonym: "diterpene phytoalexin biosynthesis" EXACT [] synonym: "diterpene phytoalexin formation" EXACT [] synonym: "diterpene phytoalexin synthesis" EXACT [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0051501 ! diterpene phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0051503 name: adenine nucleotide transport namespace: biological_process def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0051504 name: diterpene phytoalexin precursor biosynthetic process pathway namespace: biological_process def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981] synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT [] synonym: "diterpene phytoalexin precursor formation pathway" EXACT [] synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT [] xref: MetaCyc:PWY-2981 is_a: GO:0046246 ! terpene biosynthetic process relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process [Term] id: GO:0051505 name: cholesterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051506 name: ergosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051507 name: beta-sitosterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai] xref: MetaCyc:RXN-12128 is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051508 name: stigmasterol UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol." [GOC:ai] xref: MetaCyc:RXN-12126 is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051509 name: tomatidine UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai] is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity [Term] id: GO:0051510 name: regulation of unidimensional cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "regulation of cell elongation" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009826 ! unidimensional cell growth relationship: regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051511 name: negative regulation of unidimensional cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "down regulation of unidimensional cell growth" EXACT [] synonym: "down-regulation of unidimensional cell growth" EXACT [] synonym: "downregulation of unidimensional cell growth" EXACT [] synonym: "inhibition of unidimensional cell growth" NARROW [] synonym: "negative regulation of cell elongation" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009826 ! unidimensional cell growth relationship: negatively_regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051512 name: positive regulation of unidimensional cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "activation of unidimensional cell growth" NARROW [] synonym: "positive regulation of cell elongation" NARROW [] synonym: "stimulation of unidimensional cell growth" NARROW [] synonym: "up regulation of unidimensional cell growth" EXACT [] synonym: "up-regulation of unidimensional cell growth" EXACT [] synonym: "upregulation of unidimensional cell growth" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009826 ! unidimensional cell growth relationship: positively_regulates GO:0009826 ! unidimensional cell growth [Term] id: GO:0051513 name: regulation of monopolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042814 ! monopolar cell growth relationship: regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051514 name: negative regulation of monopolar cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] synonym: "down regulation of monopolar cell growth" EXACT [] synonym: "down-regulation of monopolar cell growth" EXACT [] synonym: "downregulation of monopolar cell growth" EXACT [] synonym: "inhibition of monopolar cell growth" NARROW [] is_a: GO:0051511 ! negative regulation of unidimensional cell growth is_a: GO:0051513 ! regulation of monopolar cell growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042814 ! monopolar cell growth relationship: negatively_regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051515 name: positive regulation of monopolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] synonym: "stimulation of monopolar cell growth" NARROW [] synonym: "up regulation of monopolar cell growth" EXACT [] synonym: "up-regulation of monopolar cell growth" EXACT [] synonym: "upregulation of monopolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051513 ! regulation of monopolar cell growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042814 ! monopolar cell growth relationship: positively_regulates GO:0042814 ! monopolar cell growth [Term] id: GO:0051516 name: regulation of bipolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042815 ! bipolar cell growth relationship: regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051517 name: negative regulation of bipolar cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "down regulation of bipolar cell growth" EXACT [] synonym: "down-regulation of bipolar cell growth" EXACT [] synonym: "downregulation of bipolar cell growth" EXACT [] synonym: "inhibition of bipolar cell growth" NARROW [] is_a: GO:0051511 ! negative regulation of unidimensional cell growth is_a: GO:0051516 ! regulation of bipolar cell growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042815 ! bipolar cell growth relationship: negatively_regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051518 name: positive regulation of bipolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "stimulation of bipolar cell growth" NARROW [] synonym: "up regulation of bipolar cell growth" EXACT [] synonym: "up-regulation of bipolar cell growth" EXACT [] synonym: "upregulation of bipolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051516 ! regulation of bipolar cell growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042815 ! bipolar cell growth relationship: positively_regulates GO:0042815 ! bipolar cell growth [Term] id: GO:0051519 name: activation of bipolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051518 ! positive regulation of bipolar cell growth [Term] id: GO:0051520 name: termination of bipolar cell growth namespace: biological_process def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051517 ! negative regulation of bipolar cell growth [Term] id: GO:0051521 name: termination of monopolar cell growth namespace: biological_process def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051514 ! negative regulation of monopolar cell growth [Term] id: GO:0051522 name: activation of monopolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051515 ! positive regulation of monopolar cell growth [Term] id: GO:0051523 name: cell growth mode switching, monopolar to bipolar namespace: biological_process def: "The process in which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai] synonym: "NETO" NARROW [GOC:vw] synonym: "new end take off" NARROW [GOC:vw] is_a: GO:0061171 ! establishment of bipolar cell polarity is_a: GO:0061389 ! regulation of direction of cell growth [Term] id: GO:0051524 name: cell growth mode switching, bipolar to monopolar namespace: biological_process def: "The process in which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai] is_a: GO:0061162 ! establishment of monopolar cell polarity is_a: GO:0061389 ! regulation of direction of cell growth [Term] id: GO:0051525 name: NFAT protein binding namespace: molecular_function alt_id: GO:0051526 alt_id: GO:0051527 alt_id: GO:0051528 alt_id: GO:0051529 alt_id: GO:0051530 def: "Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679] synonym: "NFAT binding" EXACT [] synonym: "NFAT1 protein binding" NARROW [] synonym: "NFAT2 protein binding" NARROW [] synonym: "NFAT3 protein binding" NARROW [] synonym: "NFAT4 protein binding" NARROW [] synonym: "NFAT5 protein binding" NARROW [] synonym: "NFATc binding" NARROW [] synonym: "NFATc1 binding" NARROW [] synonym: "NFATc2 binding" NARROW [] synonym: "NFATc3 binding" NARROW [] synonym: "NFATc4 binding" NARROW [] synonym: "NFATp binding" NARROW [] synonym: "NFATx binding" NARROW [] synonym: "non-calcium-regulated NFAT protein binding" NARROW [] synonym: "nuclear factor of activated T cell protein binding" EXACT [] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0051536 name: iron-sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] subset: goslim_metagenomics synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] xref: MIPS_funcat:16.21.08 is_a: GO:0048037 ! cofactor binding is_a: GO:0051540 ! metal cluster binding [Term] id: GO:0051537 name: 2 iron, 2 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "2 Fe 2 S cluster binding" EXACT [] synonym: "2 iron, 2 sulphur cluster binding" EXACT [] synonym: "2Fe-2S cluster binding" EXACT [] synonym: "diiron disulfide cluster binding" EXACT [] synonym: "diiron disulphide cluster binding" EXACT [] synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT [] synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051538 name: 3 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "3 Fe 4 S cluster binding" EXACT [] synonym: "3 iron, 4 sulphur cluster binding" EXACT [] synonym: "3Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT [] synonym: "triiron tetrasulfide cluster binding" EXACT [] synonym: "triiron tetrasulphide cluster binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051539 name: 4 iron, 4 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] synonym: "4 Fe 4 S cluster binding" EXACT [] synonym: "4 iron, 4 sulphur cluster binding" EXACT [] synonym: "4Fe-4S cluster binding" EXACT [] synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT [] synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT [] synonym: "tetrairon tetrasulfide cluster binding" EXACT [] synonym: "tetrairon tetrasulphide cluster binding" EXACT [] is_a: GO:0051536 ! iron-sulfur cluster binding [Term] id: GO:0051540 name: metal cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0051541 name: elastin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [http://www.onelook.com] synonym: "elastin metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0051542 name: elastin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0051541 ! elastin metabolic process [Term] id: GO:0051543 name: regulation of elastin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051542 ! elastin biosynthetic process relationship: regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051544 name: positive regulation of elastin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] synonym: "activation of elastin biosynthetic process" NARROW [] synonym: "stimulation of elastin biosynthetic process" NARROW [] synonym: "up regulation of elastin biosynthetic process" EXACT [] synonym: "up-regulation of elastin biosynthetic process" EXACT [] synonym: "upregulation of elastin biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0051543 ! regulation of elastin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051542 ! elastin biosynthetic process relationship: positively_regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051545 name: negative regulation of elastin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] synonym: "down regulation of elastin biosynthetic process" EXACT [] synonym: "down-regulation of elastin biosynthetic process" EXACT [] synonym: "downregulation of elastin biosynthetic process" EXACT [] synonym: "inhibition of elastin biosynthetic process" NARROW [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0051543 ! regulation of elastin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051542 ! elastin biosynthetic process relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process [Term] id: GO:0051546 name: keratinocyte migration namespace: biological_process def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544] is_a: GO:0010631 ! epithelial cell migration [Term] id: GO:0051547 name: regulation of keratinocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai] is_a: GO:0010632 ! regulation of epithelial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051546 ! keratinocyte migration relationship: regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051548 name: negative regulation of keratinocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "down regulation of keratinocyte migration" EXACT [] synonym: "down-regulation of keratinocyte migration" EXACT [] synonym: "downregulation of keratinocyte migration" EXACT [] synonym: "inhibition of keratinocyte migration" NARROW [] is_a: GO:0010633 ! negative regulation of epithelial cell migration is_a: GO:0051547 ! regulation of keratinocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051546 ! keratinocyte migration relationship: negatively_regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051549 name: positive regulation of keratinocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai] synonym: "activation of keratinocyte migration" NARROW [] synonym: "stimulation of keratinocyte migration" NARROW [] synonym: "up regulation of keratinocyte migration" EXACT [] synonym: "up-regulation of keratinocyte migration" EXACT [] synonym: "upregulation of keratinocyte migration" EXACT [] is_a: GO:0010634 ! positive regulation of epithelial cell migration is_a: GO:0051547 ! regulation of keratinocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051546 ! keratinocyte migration relationship: positively_regulates GO:0051546 ! keratinocyte migration [Term] id: GO:0051550 name: aurone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [PMID:20035037] synonym: "aurone metabolism" EXACT [] synonym: "benzalcoumaran-3-one metabolic process" EXACT [] synonym: "benzalcoumaran-3-one metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042440 ! pigment metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0051551 name: aurone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai, PMID:20035037] synonym: "benzalcoumaran-3-one biosynthesis" EXACT [] synonym: "benzalcoumaran-3-one biosynthetic process" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051550 ! aurone metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0051552 name: flavone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [PMID:18567791] synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW [] synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW [] synonym: "2-phenylchromone metabolic process" NARROW [] synonym: "2-phenylchromone metabolism" NARROW [] synonym: "flavone metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0051553 name: flavone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai, PMID:18567791] synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW [] synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW [] synonym: "2-phenylchromone biosynthesis" NARROW [] synonym: "2-phenylchromone biosynthetic process" NARROW [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051552 ! flavone metabolic process [Term] id: GO:0051554 name: flavonol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179] synonym: "flavonol metabolism" EXACT [] is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0051555 name: flavonol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai] xref: MetaCyc:PWY-3101 is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:0051554 ! flavonol metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0051556 name: leucoanthocyanidin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] synonym: "leucoanthocyanidin metabolism" EXACT [] xref: MetaCyc:PWY1F-823 is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0051557 name: leucoanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0051556 ! leucoanthocyanidin metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0051558 name: phlobaphene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] synonym: "phlobaphene metabolism" EXACT [] is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0051559 name: phlobaphene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] is_a: GO:0009058 ! biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0051558 ! phlobaphene metabolic process [Term] id: GO:0051560 name: mitochondrial calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in mitochondria" EXACT [] synonym: "calcium ion homeostasis in mitochondrion" EXACT [] synonym: "mitochondrial calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0051561 name: positive regulation of mitochondrial calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai] synonym: "elevation of calcium ion concentration in mitochondria" EXACT [] synonym: "elevation of calcium ion concentration in mitochondrion" EXACT [] synonym: "elevation of mitochondrial calcium ion concentration" EXACT [] synonym: "mitochondrial calcium ion concentration elevation" EXACT [] is_a: GO:0051560 ! mitochondrial calcium ion homeostasis [Term] id: GO:0051562 name: negative regulation of mitochondrial calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai] synonym: "mitochondrial calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in mitochondria" EXACT [] synonym: "reduction of calcium ion concentration in mitochondrion" EXACT [] synonym: "reduction of mitochondrial calcium ion concentration" EXACT [] is_a: GO:0051560 ! mitochondrial calcium ion homeostasis [Term] id: GO:0051563 name: smooth endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah] synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in smooth ER" EXACT [] synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in smooth ER" EXACT [] synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion concentration regulation" EXACT [] synonym: "smooth ER calcium ion homeostasis" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005790 ! smooth endoplasmic reticulum relationship: occurs_in GO:0005790 ! smooth endoplasmic reticulum [Term] id: GO:0051564 name: positive regulation of smooth endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "elevation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "elevation of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT [] is_a: GO:0032470 ! positive regulation of endoplasmic reticulum calcium ion concentration is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0051565 name: negative regulation of smooth endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] synonym: "reduction of calcium ion concentration in smooth ER" EXACT [] synonym: "reduction of smooth endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "reduction of smooth ER calcium ion concentration" EXACT [] synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT [] synonym: "smooth ER calcium ion concentration reduction" EXACT [] is_a: GO:0032471 ! negative regulation of endoplasmic reticulum calcium ion concentration is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0051566 name: anthocyanidin-3-glucoside rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800] synonym: "3RT activity" BROAD [] synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT [] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0051567 name: histone H3-K9 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone." [GOC:ai, GOC:pr] synonym: "histone H3 K9 methylation" EXACT [] synonym: "histone H3K9me" EXACT [] synonym: "histone lysine H3 K9 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation is_a: GO:0061647 ! histone H3-K9 modification [Term] id: GO:0051568 name: histone H3-K4 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr] synonym: "histone H3 K4 methylation" EXACT [] synonym: "histone H3K4me" EXACT [] synonym: "histone lysine H3 K4 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0051569 name: regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051568 ! histone H3-K4 methylation relationship: regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051570 name: regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051567 ! histone H3-K9 methylation relationship: regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051571 name: positive regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] synonym: "activation of histone H3-K4 methylation" NARROW [] synonym: "stimulation of histone H3-K4 methylation" NARROW [] synonym: "up regulation of histone H3-K4 methylation" EXACT [] synonym: "up-regulation of histone H3-K4 methylation" EXACT [] synonym: "upregulation of histone H3-K4 methylation" EXACT [] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0051569 ! regulation of histone H3-K4 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051568 ! histone H3-K4 methylation relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051572 name: negative regulation of histone H3-K4 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] synonym: "down regulation of histone H3-K4 methylation" EXACT [] synonym: "down-regulation of histone H3-K4 methylation" EXACT [] synonym: "downregulation of histone H3-K4 methylation" EXACT [] synonym: "inhibition of histone H3-K4 methylation" NARROW [] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0051569 ! regulation of histone H3-K4 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051568 ! histone H3-K4 methylation relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation [Term] id: GO:0051573 name: negative regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] synonym: "down regulation of histone H3-K9 methylation" EXACT [] synonym: "down-regulation of histone H3-K9 methylation" EXACT [] synonym: "downregulation of histone H3-K9 methylation" EXACT [] synonym: "inhibition of histone H3-K9 methylation" NARROW [] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0051570 ! regulation of histone H3-K9 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051567 ! histone H3-K9 methylation relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051574 name: positive regulation of histone H3-K9 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] synonym: "activation of histone H3-K9 methylation" NARROW [] synonym: "stimulation of histone H3-K9 methylation" NARROW [] synonym: "up regulation of histone H3-K9 methylation" EXACT [] synonym: "up-regulation of histone H3-K9 methylation" EXACT [] synonym: "upregulation of histone H3-K9 methylation" EXACT [] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0051570 ! regulation of histone H3-K9 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051567 ! histone H3-K9 methylation relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation [Term] id: GO:0051575 name: 5'-deoxyribose-5-phosphate lyase activity namespace: molecular_function def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966] synonym: "5'-deoxyribose phosphate activity" EXACT [] synonym: "dRP lyase activity" BROAD [] synonym: "dRPase activity" BROAD [] is_a: GO:0016835 ! carbon-oxygen lyase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0051580 name: regulation of neurotransmitter uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] subset: goslim_synapse synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurotransmitter reuptake" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001504 ! neurotransmitter uptake relationship: regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051581 name: negative regulation of neurotransmitter uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "down regulation of neurotransmitter uptake" EXACT [] synonym: "down-regulation of neurotransmitter uptake" EXACT [] synonym: "downregulation of neurotransmitter uptake" EXACT [] synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051589 ! negative regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001504 ! neurotransmitter uptake relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051582 name: positive regulation of neurotransmitter uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] synonym: "activation of neurotransmitter uptake" NARROW [] synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of neurotransmitter uptake" NARROW [] synonym: "up regulation of neurotransmitter uptake" EXACT [] synonym: "up-regulation of neurotransmitter uptake" EXACT [] synonym: "upregulation of neurotransmitter uptake" EXACT [] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051590 ! positive regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001504 ! neurotransmitter uptake relationship: positively_regulates GO:0001504 ! neurotransmitter uptake [Term] id: GO:0051583 name: dopamine uptake involved in synaptic transmission namespace: biological_process def: "The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] synonym: "dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] synonym: "dopamine reuptake involved in synaptic transmission" EXACT [] is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission is_a: GO:0090494 ! dopamine uptake relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0051584 name: regulation of dopamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai] synonym: "regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission [Term] id: GO:0051585 name: negative regulation of dopamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell." [GOC:ai] synonym: "down regulation of dopamine uptake involved in synaptic transmission" EXACT [] synonym: "down-regulation of dopamine uptake involved in synaptic transmission" EXACT [] synonym: "downregulation of dopamine uptake involved in synaptic transmission" EXACT [] synonym: "negative regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] is_a: GO:0032227 ! negative regulation of synaptic transmission, dopaminergic is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission [Term] id: GO:0051586 name: positive regulation of dopamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] synonym: "activation of dopamine uptake involved in synaptic transmission" NARROW [] synonym: "positive regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of dopamine uptake involved in synaptic transmission" NARROW [] synonym: "up regulation of dopamine uptake involved in synaptic transmission" EXACT [] synonym: "up-regulation of dopamine uptake involved in synaptic transmission" EXACT [] synonym: "upregulation of dopamine uptake involved in synaptic transmission" EXACT [] is_a: GO:0032226 ! positive regulation of synaptic transmission, dopaminergic is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission [Term] id: GO:0051587 name: inhibition of dopamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai] synonym: "inhibition of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] is_a: GO:0051585 ! negative regulation of dopamine uptake involved in synaptic transmission is_a: GO:0051609 ! inhibition of neurotransmitter uptake [Term] id: GO:0051588 name: regulation of neurotransmitter transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006836 ! neurotransmitter transport relationship: regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051589 name: negative regulation of neurotransmitter transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of neurotransmitter transport" EXACT [] synonym: "down-regulation of neurotransmitter transport" EXACT [] synonym: "downregulation of neurotransmitter transport" EXACT [] synonym: "inhibition of neurotransmitter transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006836 ! neurotransmitter transport relationship: negatively_regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051590 name: positive regulation of neurotransmitter transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of neurotransmitter transport" NARROW [] synonym: "stimulation of neurotransmitter transport" NARROW [] synonym: "up regulation of neurotransmitter transport" EXACT [] synonym: "up-regulation of neurotransmitter transport" EXACT [] synonym: "upregulation of neurotransmitter transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006836 ! neurotransmitter transport relationship: positively_regulates GO:0006836 ! neurotransmitter transport [Term] id: GO:0051591 name: response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai] synonym: "response to 3',5' cAMP" EXACT [] synonym: "response to 3',5'-cAMP" EXACT [] synonym: "response to adenosine 3',5'-cyclophosphate" EXACT [] synonym: "response to cyclic AMP" EXACT [] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0051592 name: response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] synonym: "response to Ca2+ ion" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0051593 name: response to folic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai] synonym: "cellular response to folate" EXACT [GOC:mah] synonym: "cellular response to vitamin B9" EXACT [GOC:mah] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0051594 name: detection of glucose namespace: biological_process def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai] synonym: "glucose detection" EXACT [] synonym: "glucose perception" RELATED [] synonym: "glucose sensing" RELATED [] is_a: GO:0009732 ! detection of hexose stimulus is_a: GO:0009749 ! response to glucose [Term] id: GO:0051595 name: response to methylglyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:ai] synonym: "response to pyruvaldehyde" EXACT [] is_a: GO:1901654 ! response to ketone [Term] id: GO:0051596 name: methylglyoxal catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] synonym: "methylglyoxal breakdown" EXACT [] synonym: "methylglyoxal catabolism" EXACT [] synonym: "methylglyoxal degradation" EXACT [] xref: MetaCyc:METHGLYUT-PWY xref: MetaCyc:Methylglyoxal-Detoxification is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0051597 name: response to methylmercury namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai] synonym: "response to CH3-Hg+" EXACT [] synonym: "response to MeHg+" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0051598 name: meiotic recombination checkpoint namespace: biological_process def: "A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568] synonym: "pachytene checkpoint" EXACT [] is_a: GO:0033313 ! meiotic cell cycle checkpoint is_a: GO:0045835 ! negative regulation of meiotic nuclear division [Term] id: GO:0051599 name: response to hydrostatic pressure namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure] synonym: "response to biomechanical stress" BROAD [] synonym: "response to static fluid pressure" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0051600 name: regulation of endocytosis by exocyst localization namespace: biological_process def: "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai, GOC:dph, GOC:tb] synonym: "regulation of endocytosis by exocyst localisation" EXACT [GOC:mah] synonym: "regulation of site selection of endocytosis" RELATED [] synonym: "relocation of endocytosis" RELATED [] synonym: "spatial regulation of endocytosis" RELATED [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051601 ! exocyst localization intersection_of: GO:0051601 ! exocyst localization intersection_of: regulates GO:0006897 ! endocytosis [Term] id: GO:0051601 name: exocyst localization namespace: biological_process def: "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai] synonym: "establishment and maintenance of exocyst localization" EXACT [] synonym: "exocyst localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization [Term] id: GO:0051602 name: response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] synonym: "response to electricity" RELATED [] xref: MIPS_funcat:34.11.08 is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0051603 name: proteolysis involved in cellular protein catabolic process namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "peptidolysis during cellular protein catabolic process" RELATED [] synonym: "peptidolysis during cellular protein catabolism" RELATED [] synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] synonym: "proteolysis during cellular protein catabolic process" RELATED [] synonym: "proteolysis during cellular protein catabolism" RELATED [] is_a: GO:0006508 ! proteolysis intersection_of: GO:0006508 ! proteolysis intersection_of: part_of GO:0044257 ! cellular protein catabolic process relationship: part_of GO:0044257 ! cellular protein catabolic process [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast is_a: GO:0019538 ! protein metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] xref: MIPS_funcat:34.11 is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051607 name: defense response to virus namespace: biological_process def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] synonym: "antiviral response" EXACT [] synonym: "defence response to virus" EXACT [] synonym: "defense response to viruses" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0009615 ! response to virus is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0051608 name: histamine transport namespace: biological_process def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015696 ! ammonium transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0051609 name: inhibition of neurotransmitter uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai] synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake [Term] id: GO:0051610 name: serotonin uptake namespace: biological_process def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] synonym: "5-HT uptake" EXACT [] synonym: "5-hydroxytryptamine uptake" EXACT [] synonym: "5HT uptake" EXACT [] synonym: "serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0098810 ! neurotransmitter reuptake [Term] id: GO:0051611 name: regulation of serotonin uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai] synonym: "regulation of 5-HT uptake" EXACT [] synonym: "regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "regulation of 5HT uptake" EXACT [] synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051580 ! regulation of neurotransmitter uptake intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051610 ! serotonin uptake relationship: regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051612 name: negative regulation of serotonin uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] synonym: "down regulation of serotonin uptake" EXACT [] synonym: "down-regulation of serotonin uptake" EXACT [] synonym: "downregulation of serotonin uptake" EXACT [] synonym: "negative regulation of 5-HT uptake" EXACT [] synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "negative regulation of 5HT uptake" EXACT [] synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051611 ! regulation of serotonin uptake intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051610 ! serotonin uptake relationship: negatively_regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051613 name: positive regulation of serotonin uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] synonym: "activation of serotonin uptake" NARROW [] synonym: "positive regulation of 5-HT uptake" EXACT [] synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT [] synonym: "positive regulation of 5HT uptake" EXACT [] synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of serotonin uptake" NARROW [] synonym: "up regulation of serotonin uptake" EXACT [] synonym: "up-regulation of serotonin uptake" EXACT [] synonym: "upregulation of serotonin uptake" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051611 ! regulation of serotonin uptake intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051610 ! serotonin uptake relationship: positively_regulates GO:0051610 ! serotonin uptake [Term] id: GO:0051614 name: inhibition of serotonin uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai] synonym: "inhibition of 5-HT uptake" EXACT [] synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT [] synonym: "inhibition of 5HT uptake" EXACT [] synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051612 ! negative regulation of serotonin uptake [Term] id: GO:0051615 name: histamine uptake namespace: biological_process def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] synonym: "histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0051608 ! histamine transport [Term] id: GO:0051616 name: regulation of histamine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051580 ! regulation of neurotransmitter uptake intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051615 ! histamine uptake relationship: regulates GO:0051615 ! histamine uptake [Term] id: GO:0051617 name: negative regulation of histamine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "down regulation of histamine uptake" EXACT [] synonym: "down-regulation of histamine uptake" EXACT [] synonym: "downregulation of histamine uptake" EXACT [] synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051615 ! histamine uptake relationship: negatively_regulates GO:0051615 ! histamine uptake [Term] id: GO:0051618 name: positive regulation of histamine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] synonym: "activation of histamine uptake" NARROW [] synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of histamine uptake" NARROW [] synonym: "up regulation of histamine uptake" EXACT [] synonym: "up-regulation of histamine uptake" EXACT [] synonym: "upregulation of histamine uptake" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051616 ! regulation of histamine uptake intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051615 ! histamine uptake relationship: positively_regulates GO:0051615 ! histamine uptake [Term] id: GO:0051619 name: inhibition of histamine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai] synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051617 ! negative regulation of histamine uptake [Term] id: GO:0051620 name: norepinephrine uptake namespace: biological_process def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "levarterenol reuptake" EXACT [] synonym: "levarterenol uptake" EXACT [] synonym: "noradrenaline reuptake" EXACT [] synonym: "noradrenaline uptake" EXACT [] synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "norepinephrine reuptake" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0090493 ! catecholamine uptake [Term] id: GO:0051621 name: regulation of norepinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] synonym: "regulation of levarterenol uptake" EXACT [] synonym: "regulation of noradrenaline uptake" EXACT [] synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051620 ! norepinephrine uptake relationship: regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051622 name: negative regulation of norepinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "down regulation of norepinephrine uptake" EXACT [] synonym: "down-regulation of norepinephrine uptake" EXACT [] synonym: "downregulation of norepinephrine uptake" EXACT [] synonym: "negative regulation of levarterenol uptake" EXACT [] synonym: "negative regulation of noradrenaline uptake" EXACT [] synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051620 ! norepinephrine uptake relationship: negatively_regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051623 name: positive regulation of norepinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "activation of norepinephrine uptake" NARROW [] synonym: "positive regulation of levarterenol uptake" EXACT [] synonym: "positive regulation of noradrenaline uptake" EXACT [] synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of norepinephrine uptake" NARROW [] synonym: "up regulation of norepinephrine uptake" EXACT [] synonym: "up-regulation of norepinephrine uptake" EXACT [] synonym: "upregulation of norepinephrine uptake" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051620 ! norepinephrine uptake relationship: positively_regulates GO:0051620 ! norepinephrine uptake [Term] id: GO:0051624 name: inhibition of norepinephrine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "inhibition of levarterenol uptake" EXACT [] synonym: "inhibition of noradrenaline uptake" EXACT [] synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051622 ! negative regulation of norepinephrine uptake [Term] id: GO:0051625 name: epinephrine uptake namespace: biological_process def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] synonym: "adrenaline reuptake" EXACT [] synonym: "adrenaline uptake" EXACT [] synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "epinephrine reuptake" EXACT [] is_a: GO:0048241 ! epinephrine transport is_a: GO:0090493 ! catecholamine uptake [Term] id: GO:0051626 name: regulation of epinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai] synonym: "regulation of adrenaline uptake" EXACT [] synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051625 ! epinephrine uptake relationship: regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051627 name: negative regulation of epinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "down regulation of epinephrine uptake" EXACT [] synonym: "down-regulation of epinephrine uptake" EXACT [] synonym: "downregulation of epinephrine uptake" EXACT [] synonym: "negative regulation of adrenaline uptake" EXACT [] synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051626 ! regulation of epinephrine uptake intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051625 ! epinephrine uptake relationship: negatively_regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051628 name: positive regulation of epinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "activation of epinephrine uptake" NARROW [] synonym: "positive regulation of adrenaline uptake" EXACT [] synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of epinephrine uptake" NARROW [] synonym: "up regulation of epinephrine uptake" EXACT [] synonym: "up-regulation of epinephrine uptake" EXACT [] synonym: "upregulation of epinephrine uptake" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051626 ! regulation of epinephrine uptake intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051625 ! epinephrine uptake relationship: positively_regulates GO:0051625 ! epinephrine uptake [Term] id: GO:0051629 name: inhibition of epinephrine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai] synonym: "inhibition of adrenaline uptake" EXACT [] synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051627 ! negative regulation of epinephrine uptake [Term] id: GO:0051630 name: acetylcholine uptake namespace: biological_process def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0098657 ! import into cell [Term] id: GO:0051631 name: regulation of acetylcholine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0051952 ! regulation of amine transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051630 ! acetylcholine uptake relationship: regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051632 name: negative regulation of acetylcholine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "down regulation of acetylcholine uptake" EXACT [] synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake relationship: negatively_regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051633 name: positive regulation of acetylcholine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "activation of acetylcholine uptake" NARROW [] synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of acetylcholine uptake" NARROW [] synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake relationship: positively_regulates GO:0051630 ! acetylcholine uptake [Term] id: GO:0051634 name: inhibition of acetylcholine uptake namespace: biological_process def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051609 ! inhibition of neurotransmitter uptake is_a: GO:0051632 ! negative regulation of acetylcholine uptake [Term] id: GO:0051635 name: obsolete bacterial cell surface binding namespace: molecular_function alt_id: GO:0008367 def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a bacterial cell." [GOC:ai] comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. synonym: "bacterial binding" EXACT [] synonym: "bacterial cell surface binding" EXACT [] synonym: "bacterium binding" EXACT [] synonym: "bacterium cell surface binding" EXACT [] synonym: "binding to bacterium" EXACT [] is_obsolete: true consider: GO:0003823 consider: GO:0005102 consider: GO:0042742 [Term] id: GO:0051636 name: obsolete Gram-negative bacterial cell surface binding namespace: molecular_function alt_id: GO:0008368 def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a Gram-negative bacterial cell." [GOC:ai] comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion. synonym: "binding to Gram-negative bacterium" EXACT [] synonym: "Gram-negative bacterial binding" EXACT [] synonym: "Gram-negative bacterial cell surface binding" EXACT [] synonym: "Gram-negative bacterium binding" EXACT [] synonym: "Gram-negative bacterium cell surface binding" EXACT [] is_obsolete: true consider: GO:0003823 consider: GO:0050829 [Term] id: GO:0051637 name: obsolete Gram-positive bacterial cell surface binding namespace: molecular_function alt_id: GO:0051076 def: "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a Gram-positive bacterium." [GOC:ai] comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion. synonym: "binding to Gram-positive bacterium" EXACT [] synonym: "Gram-positive bacterial binding" EXACT [] synonym: "Gram-positive bacterial cell surface binding" EXACT [] synonym: "Gram-positive bacterium binding" EXACT [] synonym: "Gram-positive bacterium cell surface binding" EXACT [] is_obsolete: true consider: GO:0003823 consider: GO:0050830 [Term] id: GO:0051638 name: barbed-end actin filament uncapping namespace: biological_process def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "barbed end actin filament uncapping" EXACT [] synonym: "barbed end F-actin uncapping" EXACT [] synonym: "barbed-end F-actin uncapping" EXACT [] synonym: "plus end actin filament uncapping" EXACT [] synonym: "plus end F-actin uncapping" EXACT [] synonym: "plus-end actin filament uncapping" EXACT [] synonym: "plus-end F-actin uncapping" EXACT [] is_a: GO:0051695 ! actin filament uncapping [Term] id: GO:0051639 name: actin filament network formation namespace: biological_process def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai] synonym: "actin gel biosynthesis" EXACT [] synonym: "actin gel formation" EXACT [] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0051179 ! localization created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051642 name: centrosome localization namespace: biological_process def: "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "centrosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of centrosome localization" EXACT [] is_a: GO:0051640 ! organelle localization is_a: GO:0061842 ! microtubule organizing center localization [Term] id: GO:0051643 name: endoplasmic reticulum localization namespace: biological_process def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah] synonym: "ER localization" EXACT [GOC:dph] synonym: "establishment and maintenance of ER localization" EXACT [] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051644 name: plastid localization namespace: biological_process def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of plastid localization" EXACT [] synonym: "plastid localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051645 name: Golgi localization namespace: biological_process def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of Golgi localization" EXACT [] synonym: "Golgi apparatus localization" EXACT [] synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051651 name: maintenance of location in cell namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] synonym: "cellular retention" NARROW [] synonym: "cellular sequestering" NARROW [] synonym: "cellular storage" NARROW [] synonym: "intracellular retention" NARROW [] synonym: "intracellular sequestering" NARROW [] synonym: "intracellular storage" NARROW [] synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of intracellular localization" NARROW [] synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of localization within cell" NARROW [] synonym: "retention within cell" NARROW [] synonym: "sequestering within cell" NARROW [] synonym: "storage within cell" NARROW [] is_a: GO:0009987 ! cellular process is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0051641 ! cellular localization [Term] id: GO:0051652 name: maintenance of chromosome location namespace: biological_process def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0050000 ! chromosome localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051653 name: spindle localization namespace: biological_process def: "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of spindle localization" EXACT [] synonym: "spindle localisation" EXACT [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0051640 ! organelle localization [Term] id: GO:0051654 name: establishment of mitochondrion localization namespace: biological_process def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] synonym: "establishment of mitochondria localization" EXACT [] synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah] synonym: "mitochondria positioning" EXACT [] synonym: "mitochondrial migration" EXACT [] synonym: "mitochondrion positioning" EXACT [] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051655 name: maintenance of vesicle location namespace: biological_process def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051648 ! vesicle localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization [Term] id: GO:0051657 name: maintenance of organelle location namespace: biological_process def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0051640 ! organelle localization [Term] id: GO:0051658 name: maintenance of nucleus location namespace: biological_process def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of cell nucleus location" EXACT [] synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051647 ! nucleus localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051659 name: maintenance of mitochondrion location namespace: biological_process def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of mitochondria localization" EXACT [] synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051660 name: establishment of centrosome localization namespace: biological_process def: "The directed movement of the centrosome to a specific location." [GOC:ai] synonym: "centrosome positioning" EXACT [] synonym: "establishment of centrosome localisation" EXACT [GOC:mah] is_a: GO:0051642 ! centrosome localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051661 name: maintenance of centrosome location namespace: biological_process def: "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051642 ! centrosome localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051663 name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0051662 def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT [] synonym: "oocyte axis determination, oocyte nucleus localization" EXACT [] synonym: "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0051647 ! nucleus localization intersection_of: GO:0051647 ! nucleus localization intersection_of: part_of GO:0007310 ! oocyte dorsal/ventral axis specification relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0051664 name: nuclear pore localization namespace: biological_process def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of nuclear pore localization" EXACT [] synonym: "nuclear pore localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization is_a: GO:0051668 ! localization within membrane [Term] id: GO:0051665 name: membrane raft localization namespace: biological_process def: "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198] synonym: "establishment and maintenance of membrane raft localization" EXACT [] synonym: "lipid raft localization" EXACT [] synonym: "membrane raft localisation" EXACT [GOC:mah] is_a: GO:0051668 ! localization within membrane [Term] id: GO:0051666 name: actin cortical patch localization namespace: biological_process def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah] synonym: "actin cortical patch localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of actin cortical patch localization" EXACT [] is_a: GO:0051641 ! cellular localization [Term] id: GO:0051667 name: establishment of plastid localization namespace: biological_process def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] synonym: "establishment of plastid localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: occurs_in GO:0016020 ! membrane relationship: occurs_in GO:0016020 ! membrane [Term] id: GO:0051669 name: fructan beta-fructosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80] synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80] synonym: "exo-beta-D-fructosidase activity" EXACT [] synonym: "exo-beta-fructosidase activity" EXACT [] synonym: "fructan b-fructosidase activity" EXACT [] synonym: "fructan exohydrolase activity" EXACT [] synonym: "fructanase activity" EXACT [EC:3.2.1.80] synonym: "polysaccharide beta-fructofuranosidase activity" EXACT [] xref: EC:3.2.1.80 xref: MetaCyc:3.2.1.80-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051670 name: inulinase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7] synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT [] synonym: "endo-inulinase activity" EXACT [] synonym: "exoinulinase activity" EXACT [] synonym: "indoinulinase activity" EXACT [] synonym: "inulase activity" EXACT [] xref: EC:3.2.1.7 xref: MetaCyc:3.2.1.7-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051671 name: induction of autolysin activity in other organism namespace: biological_process def: "Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai] synonym: "activation of autolysin activity in another organism" EXACT [] synonym: "activation of autolysis in other organism" NARROW [] synonym: "activation of autolytic activity in other organism" NARROW [] synonym: "induction of autolysin activity in another organism" EXACT [GOC:bf] synonym: "induction of autolysis in other organism" NARROW [] synonym: "induction of autolytic activity in other organism" NARROW [] synonym: "positive regulation of autolysin activity in another organism" BROAD [] is_a: GO:0043946 ! positive regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0051672 name: catabolism by organism of cell wall peptidoglycan in other organism namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai] synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT [] synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT [] synonym: "cell wall catabolic process in other organism" NARROW [] synonym: "cell wall catabolism in other organism" NARROW [] synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT [] is_a: GO:0009253 ! peptidoglycan catabolic process is_a: GO:0044041 ! multi-organism carbohydrate catabolic process relationship: part_of GO:0009617 ! response to bacterium relationship: part_of GO:0044278 ! cell wall disruption in other organism [Term] id: GO:0051673 name: membrane disruption in other organism namespace: biological_process def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai] synonym: "cytolysis, by membrane disruption, in other organism" NARROW [] synonym: "membrane disruption in another organism" EXACT [GOC:bf] is_a: GO:0035821 ! modification of morphology or physiology of other organism [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051675 name: isopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57] synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT [] xref: EC:3.2.1.57 xref: MetaCyc:3.2.1.57-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0051676 name: pullulan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381] synonym: "pullulan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0051677 name: pullulan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0051676 ! pullulan metabolic process [Term] id: GO:0051678 name: pullulan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051676 ! pullulan metabolic process [Term] id: GO:0051679 name: 6-alpha-maltosylglucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem_Compound:439991] synonym: "6-alpha-maltosylglucose metabolism" EXACT [] synonym: "isopanose metabolic process" EXACT [] synonym: "isopanose metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0051680 name: 6-alpha-maltosylglucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] synonym: "isopanose biosynthesis" EXACT [] synonym: "isopanose biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process [Term] id: GO:0051681 name: 6-alpha-maltosylglucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] synonym: "isopanose catabolic process" EXACT [] synonym: "isopanose catabolism" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process [Term] id: GO:0051682 name: galactomannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0051069 ! galactomannan metabolic process [Term] id: GO:0051683 name: establishment of Golgi localization namespace: biological_process def: "The directed movement of the Golgi to a specific location." [GOC:ai] synonym: "establishment of Golgi apparatus localization" EXACT [] synonym: "establishment of Golgi body localization" EXACT [] synonym: "establishment of Golgi localisation" EXACT [GOC:mah] is_a: GO:0051645 ! Golgi localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051684 name: maintenance of Golgi location namespace: biological_process def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of Golgi apparatus localization" EXACT [] synonym: "maintenance of Golgi body localization" EXACT [] synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051645 ! Golgi localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051685 name: maintenance of ER location namespace: biological_process def: "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of endoplasmic reticulum localization" EXACT [] synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051643 ! endoplasmic reticulum localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051686 name: establishment of ER localization namespace: biological_process def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai] synonym: "establishment of endoplasmic reticulum localization" EXACT [] synonym: "establishment of ER localisation" EXACT [GOC:mah] is_a: GO:0051643 ! endoplasmic reticulum localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0051687 name: maintenance of spindle location namespace: biological_process def: "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051653 ! spindle localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051688 name: maintenance of plastid location namespace: biological_process def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051644 ! plastid localization is_a: GO:0051657 ! maintenance of organelle location [Term] id: GO:0051691 name: cellular oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] synonym: "cellular oligosaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0051692 name: cellular oligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] synonym: "cellular oligosaccharide breakdown" EXACT [] synonym: "cellular oligosaccharide catabolism" EXACT [] synonym: "cellular oligosaccharide degradation" EXACT [] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0051691 ! cellular oligosaccharide metabolic process [Term] id: GO:0051693 name: actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "actin capping activity" RELATED [] synonym: "F-actin capping activity" RELATED [] is_a: GO:0030835 ! negative regulation of actin filament depolymerization is_a: GO:0030837 ! negative regulation of actin filament polymerization [Term] id: GO:0051694 name: pointed-end actin filament capping namespace: biological_process def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] synonym: "minus-end actin filament capping activity" EXACT [] synonym: "minus-end F-actin capping activity" EXACT [] synonym: "pointed-end actin capping activity" EXACT [] synonym: "pointed-end F-actin capping activity" EXACT [] is_a: GO:0051693 ! actin filament capping [Term] id: GO:0051695 name: actin filament uncapping namespace: biological_process def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "F-actin uncapping" EXACT [] is_a: GO:0030836 ! positive regulation of actin filament depolymerization [Term] id: GO:0051696 name: pointed-end actin filament uncapping namespace: biological_process def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] synonym: "minus end actin filament uncapping" EXACT [] synonym: "minus end F-actin uncapping" EXACT [] synonym: "minus-end actin filament uncapping" EXACT [] synonym: "minus-end F-actin uncapping" EXACT [] synonym: "pointed end actin filament uncapping" EXACT [] synonym: "pointed end F-actin uncapping" EXACT [] synonym: "pointed-end F-actin uncapping" EXACT [] is_a: GO:0051695 ! actin filament uncapping [Term] id: GO:0051697 name: protein delipidation namespace: biological_process def: "The breakage of covalent bonds to detach lipid groups from a protein." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0051698 name: saccharopine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628] synonym: "SAX activity" BROAD [] is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051699 name: proline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] xref: MetaCyc:RXN-821 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051700 name: fructosyl-amino acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628] synonym: "FAOD activity" EXACT [] is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0051701 name: interaction with host namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] is_a: GO:0044403 ! symbiotic process [Term] id: GO:0051702 name: interaction with symbiont namespace: biological_process def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] is_a: GO:0044419 ! interspecies interaction between organisms relationship: part_of GO:0044403 ! symbiotic process [Term] id: GO:0051703 name: intraspecies interaction between organisms namespace: biological_process def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai] subset: goslim_pir synonym: "intraspecies interaction with other organisms" EXACT [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051704 name: multi-organism process namespace: biological_process alt_id: GO:0051706 def: "A biological process which involves another organism of the same or different species." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "interaction between organisms" EXACT [] synonym: "physiological interaction between organisms" EXACT [] synonym: "physiological interaction with other organism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051705 name: multi-organism behavior namespace: biological_process alt_id: GO:0023032 alt_id: GO:0044709 def: "Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai] subset: goslim_pir synonym: "behavioral interaction between organisms" EXACT [] synonym: "behavioral interaction with other organism" EXACT [] synonym: "behavioral signaling" NARROW [] synonym: "behavioral signalling" NARROW [GOC:mah] synonym: "behavioural interaction between organisms" EXACT [] synonym: "behavioural interaction with other organism" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0051704 ! multi-organism process [Term] id: GO:0051709 name: regulation of killing of cells of other organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031640 ! killing of cells of other organism relationship: regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051710 name: regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001902 def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] synonym: "regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "regulation of cytolysis of cells of another, non-host, organism" NARROW [] is_a: GO:0042268 ! regulation of cytolysis is_a: GO:0051709 ! regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051715 ! cytolysis in other organism relationship: regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051711 name: negative regulation of killing of cells of other organism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "down regulation of killing of cells of another organism" EXACT [] synonym: "down-regulation of killing of cells of another organism" EXACT [] synonym: "downregulation of killing of cells of another organism" EXACT [] synonym: "inhibition of killing of cells of another organism" NARROW [] synonym: "negative regulation of killing of cells of another organism" EXACT [GOC:bf] is_a: GO:0031342 ! negative regulation of cell killing is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051709 ! regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031640 ! killing of cells of other organism relationship: negatively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051712 name: positive regulation of killing of cells of other organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] synonym: "activation of killing of cells of another organism" NARROW [] synonym: "stimulation of killing of cells of another organism" NARROW [] synonym: "up regulation of killing of cells of another organism" EXACT [] synonym: "up-regulation of killing of cells of another organism" EXACT [] synonym: "upregulation of killing of cells of another organism" EXACT [] is_a: GO:0031343 ! positive regulation of cell killing is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051709 ! regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031640 ! killing of cells of other organism relationship: positively_regulates GO:0031640 ! killing of cells of other organism [Term] id: GO:0051713 name: negative regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001903 def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai] synonym: "down regulation of cytolysis of cells of another organism" EXACT [] synonym: "down-regulation of cytolysis of cells of another organism" EXACT [] synonym: "downregulation of cytolysis of cells of another organism" EXACT [] synonym: "inhibition of cytolysis of cells of another organism" NARROW [] synonym: "negative regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "negative regulation of cytolysis of cells of another, non-host, organism" NARROW [] is_a: GO:0045918 ! negative regulation of cytolysis is_a: GO:0051710 ! regulation of cytolysis in other organism is_a: GO:0051711 ! negative regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051715 ! cytolysis in other organism relationship: negatively_regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051714 name: positive regulation of cytolysis in other organism namespace: biological_process alt_id: GO:0001904 def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] synonym: "activation of cytolysis of cells of another organism" NARROW [] synonym: "positive regulation of cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "positive regulation of cytolysis of cells of another, non-host, organism" NARROW [] synonym: "stimulation of cytolysis of cells of another organism" NARROW [] synonym: "up regulation of cytolysis of cells of another organism" EXACT [] synonym: "up-regulation of cytolysis of cells of another organism" EXACT [] synonym: "upregulation of cytolysis of cells of another organism" EXACT [] is_a: GO:0045919 ! positive regulation of cytolysis is_a: GO:0051710 ! regulation of cytolysis in other organism is_a: GO:0051712 ! positive regulation of killing of cells of other organism intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051715 ! cytolysis in other organism relationship: positively_regulates GO:0051715 ! cytolysis in other organism [Term] id: GO:0051715 name: cytolysis in other organism namespace: biological_process alt_id: GO:0001901 def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai] synonym: "cytolysis of cells of another organism" EXACT [GOC:bf] synonym: "cytolysis of cells of another, non-host, organism" NARROW [] synonym: "cytolysis of cells of competing organism" NARROW [] is_a: GO:0019835 ! cytolysis is_a: GO:0031640 ! killing of cells of other organism is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051717 name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN] synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-] synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-] xref: MetaCyc:3.1.3.62-RXN xref: Reactome:R-HSA-1855200 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen" xref: Reactome:R-HSA-1855205 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol" is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity [Term] id: GO:0051718 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)." [EC:2.1.1.37, PMID:15689527] synonym: "HpaII methylase" NARROW [EC:2.1.1.37] synonym: "HpaII' methylase" NARROW [EC:2.1.1.37] synonym: "M.BsuRIa" NARROW [EC:2.1.1.37] synonym: "M.BsuRIb" NARROW [EC:2.1.1.37] xref: Reactome:R-HSA-5334151 "DNMT1 methylates cytosine in hemimethylated DNA" is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051719 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527] xref: Reactome:R-HSA-5334097 "DNMT3B:DNMT3L methylates cytosine in DNA" xref: Reactome:R-HSA-5334152 "DNMT3A:DNMT3L methylates cytosine in DNA" is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051720 name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527] is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity [Term] id: GO:0051721 name: protein phosphatase 2A binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2A." [GOC:ai] synonym: "protein phosphatase 2 binding" RELATED [GOC:rl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0051722 name: protein C-terminal methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216] synonym: "protein phosphatase methylesterase activity" NARROW [] xref: Reactome:R-HSA-8856951 "PP2A demethylation by PPME1" is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0051723 name: protein methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai] synonym: "PME activity" EXACT [EC:2.7.1.-] synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-] synonym: "protein carboxylic ester hydrolase activity" EXACT [] synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-] xref: Reactome:R-HSA-5367022 "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2" is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0051724 name: NAD transmembrane transporter activity namespace: molecular_function alt_id: GO:1901368 def: "Enables the transfer of NAD from one side of a membrane to the other." [GOC:TermGenie] comment: NAD carrier synonym: "NAD (oxidized) transporter activity" EXACT [] synonym: "NAD (reduced) transporter activity" EXACT [] synonym: "NAD transporter activity" RELATED [] synonym: "NAD+ transporter activity" EXACT [] synonym: "NADH transporter activity" EXACT [] synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "oxidized NAD transporter activity" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "reduced NAD transporter activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity relationship: part_of GO:0035352 ! NAD transmembrane transport created_by: jl creation_date: 2012-09-19T13:21:08Z [Term] id: GO:0051725 name: protein de-ADP-ribosylation namespace: biological_process def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai] synonym: "poly(ADP-ribose) removal from protein" EXACT [] synonym: "protein amino acid de-ADP-ribosylation" EXACT [GOC:bf] synonym: "protein poly(ADP-ribose) catabolic process" EXACT [] synonym: "protein poly(ADP-ribose) catabolism" EXACT [] synonym: "protein poly(ADP-ribose) degradation" EXACT [] synonym: "protein poly(ADP-ribose) hydrolysis" EXACT [] synonym: "removal of ADP-ribose from protein" EXACT [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007049 ! cell cycle relationship: regulates GO:0007049 ! cell cycle [Term] id: GO:0051727 name: obsolete cell cycle switching, meiotic to mitotic cell cycle namespace: biological_process def: "OBSOLETE. The process in which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai, GOC:mtg_cell_cycle] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "cell cycle switching, meiosis to mitosis" NARROW [] synonym: "cell cycle switching, meiotic to mitotic cell cycle" EXACT [] synonym: "conversion to mitosis" NARROW [] synonym: "conversion to mitotic cell cycle" EXACT [] synonym: "entry into mitosis" NARROW [] synonym: "entry into mitotic cell cycle" EXACT [] synonym: "initiation of mitosis" NARROW [] synonym: "initiation of mitotic cell cycle" EXACT [] synonym: "mitotic entry" NARROW [] is_obsolete: true [Term] id: GO:0051728 name: cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process alt_id: GO:0042061 def: "The process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai, GOC:mtg_cell_cycle] synonym: "cell cycle switching, mitosis to meiosis" NARROW [] synonym: "conversion to meiosis" NARROW [] synonym: "conversion to meiotic cell cycle" EXACT [] synonym: "entry into meiosis" NARROW [] synonym: "entry into meiotic cell cycle" EXACT [] synonym: "initiation of meiosis" NARROW [] synonym: "initiation of meiotic cell cycle" EXACT [] synonym: "meiotic entry" NARROW [] is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0060184 ! cell cycle switching [Term] id: GO:0051729 name: germline cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] synonym: "germline cell cycle switching, mitosis to meiosis" NARROW [] synonym: "germline conversion to meiosis" NARROW [] synonym: "germline conversion to meiotic cell cycle" EXACT [] synonym: "germline entry into meiosis" NARROW [] synonym: "germline entry into meiotic cell cycle" EXACT [] synonym: "germline initiation of meiosis" NARROW [] synonym: "germline initiation of meiotic cell cycle" EXACT [] synonym: "germline meiotic entry" NARROW [] is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle [Term] id: GO:0051730 name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent RNA kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051732 ! polyribonucleotide kinase activity is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity [Term] id: GO:0051731 name: polynucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "5'-dephosphopolynucleotide kinase activity" EXACT [] synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "PNK" RELATED [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78] synonym: "polynucleotide kinase activity" BROAD [EC:2.7.1.78] xref: EC:2.7.1 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0051732 name: polyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78] synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78] synonym: "RNA 5'-hydroxyl kinase activity" EXACT [] synonym: "RNA kinase activity" EXACT [] is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051733 name: polydeoxyribonucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78] synonym: "DNA 5'-hydroxyl kinase activity" EXACT [] synonym: "DNA kinase activity" EXACT [] is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051734 name: ATP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.78 is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051735 name: GTP-dependent polynucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] id: GO:0051736 name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78] synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT [] synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP-dependent RNA kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051732 ! polyribonucleotide kinase activity is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity [Term] id: GO:0051737 name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918] synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] synonym: "GTP-dependent DNA kinase activity" EXACT [] synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT [] synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity [Term] id: GO:0051738 name: xanthophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031409 ! pigment binding [Term] id: GO:0051740 name: ethylene binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] synonym: "ethene binding" EXACT [] is_a: GO:0042562 ! hormone binding is_a: GO:0072328 ! alkene binding [Term] id: GO:0051741 name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] synonym: "MPBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2542 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0051742 name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] synonym: "MSBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2762 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0051743 name: red chlorophyll catabolite reductase activity namespace: molecular_function def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659] synonym: "RCC reductase activity" EXACT [] xref: MetaCyc:RXN-7741 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0051744 name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity namespace: molecular_function def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] xref: MetaCyc:RXN1F-72 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0051745 name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2] synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2] synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT [] xref: EC:1.17.1.2 xref: MetaCyc:ISPH2-RXN is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0051746 name: thalianol synthase activity namespace: molecular_function def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655] xref: EC:5.4.99.31 xref: RHEA:26163 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0051747 name: cytosine C-5 DNA demethylase activity namespace: molecular_function def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851] synonym: "DNA demethylase activity" BROAD [PMID:10050851] synonym: "DNA methyltransferase activity acting on cytosine C-5" EXACT [] synonym: "hydrolytic DNA demethylase activity" BROAD [] is_a: GO:0016787 ! hydrolase activity is_a: GO:0035514 ! DNA demethylase activity [Term] id: GO:0051748 name: UTP-monosaccharide-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] synonym: "PsUSP" RELATED [EC:2.7.7.64] synonym: "UDP-monosaccharide diphosphorylase activity" EXACT [] synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT [] synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64] synonym: "USP" RELATED [EC:2.7.7.64] xref: EC:2.7.7.64 xref: MetaCyc:2.7.7.64-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0051749 name: indole acetic acid carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896] synonym: "IAA carboxyl methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0051750 name: delta3,5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function alt_id: GO:0008416 def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:11278886, PMID:16040662] synonym: "delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity" EXACT [] synonym: "delta5-delta2,4-dienoyl-CoA isomerase activity" RELATED [] is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0051751 name: alpha-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage." [PMID:15772281] is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0051752 name: phosphoglucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411] synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5] synonym: "OK1" RELATED [EC:2.7.9.5] synonym: "PWD" RELATED [EC:2.7.9.5] xref: EC:2.7.9.5 xref: MetaCyc:2.7.9.5-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0051753 name: mannan synthase activity namespace: molecular_function def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan." [PMID:14726589] synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW [] synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT [] is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0051754 name: meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] is_a: GO:0051177 ! meiotic sister chromatid cohesion is_a: GO:0070601 ! centromeric sister chromatid cohesion [Term] id: GO:0051755 name: meiotic sister chromatid arm separation namespace: biological_process def: "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [GOC:ai] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I relationship: part_of GO:0051757 ! meiotic sister chromatid separation [Term] id: GO:0051756 name: meiotic sister chromatid centromere separation namespace: biological_process def: "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] is_a: GO:0034510 ! centromere separation is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0045144 ! meiotic sister chromatid segregation relationship: part_of GO:0051757 ! meiotic sister chromatid separation [Term] id: GO:0051757 name: meiotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation [Term] id: GO:0051758 name: homologous chromosome movement towards spindle pole in meiosis I anaphase namespace: biological_process def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase." [GOC:ai] synonym: "homologous chromosome movement towards spindle pole during meiosis I" RELATED [GOC:dph, GOC:tb] synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0051759 name: sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation namespace: biological_process def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai] synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during meiosis II" RELATED [GOC:dph, GOC:tb] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole relationship: part_of GO:0045144 ! meiotic sister chromatid segregation [Term] id: GO:0051760 name: meiotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid cohesion along arms" EXACT [] synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] is_a: GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0051761 name: sesquiterpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] synonym: "sesquiterpene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0051762 name: sesquiterpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0051763 name: sesquiterpene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] is_a: GO:0046247 ! terpene catabolic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0051764 name: actin crosslink formation namespace: biological_process def: "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai] comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'. synonym: "actin bundling" RELATED [] synonym: "actin crosslinking" EXACT [] synonym: "bridging actin filaments" NARROW [] synonym: "formation of actin crosslink" EXACT [] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0051765 name: inositol tetrakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0051766 name: inositol trisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0051767 name: nitric-oxide synthase biosynthetic process namespace: biological_process alt_id: GO:0051768 def: "The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai] synonym: "brain nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] synonym: "endothelial nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] synonym: "inducible nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] synonym: "nitric-oxide synthase (type 2) biosynthesis" NARROW [] synonym: "nitric-oxide synthase (type 2) biosynthetic process" NARROW [] synonym: "nitric-oxide synthase (type II) biosynthesis" NARROW [] synonym: "nitric-oxide synthase (type II) biosynthetic process" NARROW [] synonym: "nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "nitric-oxide synthase-1 biosynthetic process" NARROW [GOC:bf] synonym: "nitric-oxide synthase-2 biosynthetic process" NARROW [GOC:bf] synonym: "nitric-oxide synthase-3 biosynthetic process" NARROW [GOC:bf] synonym: "NO synthase biosynthesis" EXACT [] synonym: "NO synthase biosynthetic process" EXACT [] synonym: "NOS biosynthesis" EXACT [] synonym: "NOS biosynthetic process" EXACT [] synonym: "NOS1 biosynthesis" NARROW [GOC:bf] synonym: "NOS2 biosynthesis" NARROW [GOC:bf] synonym: "NOS2 synthase biosynthesis" NARROW [] synonym: "NOS2 synthase biosynthetic process" NARROW [] synonym: "NOS3 biosynthesis" NARROW [GOC:bf] is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0051769 name: regulation of nitric-oxide synthase biosynthetic process namespace: biological_process alt_id: GO:0051772 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai] synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] synonym: "regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "regulation of NO synthase biosynthesis" EXACT [] synonym: "regulation of NO synthase biosynthetic process" EXACT [] synonym: "regulation of NOS biosynthesis" EXACT [] synonym: "regulation of NOS biosynthetic process" EXACT [] synonym: "regulation of NOS2 synthase biosynthesis" NARROW [] synonym: "regulation of NOS2 synthase biosynthetic process" NARROW [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051770 name: positive regulation of nitric-oxide synthase biosynthetic process namespace: biological_process alt_id: GO:0051773 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme." [GOC:ai] synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] synonym: "positive regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "positive regulation of NO synthase biosynthesis" EXACT [] synonym: "positive regulation of NO synthase biosynthetic process" EXACT [] synonym: "positive regulation of NOS biosynthesis" EXACT [] synonym: "positive regulation of NOS biosynthetic process" EXACT [] synonym: "positive regulation of NOS2 synthase biosynthesis" NARROW [] synonym: "positive regulation of NOS2 synthase biosynthetic process" NARROW [] synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051771 name: negative regulation of nitric-oxide synthase biosynthetic process namespace: biological_process alt_id: GO:0051774 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai] synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT [] synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW [] synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] synonym: "negative regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] synonym: "negative regulation of NO synthase biosynthesis" EXACT [] synonym: "negative regulation of NO synthase biosynthetic process" EXACT [] synonym: "negative regulation of NOS biosynthesis" EXACT [] synonym: "negative regulation of NOS biosynthetic process" EXACT [] synonym: "negative regulation of NOS2 synthase biosynthesis" NARROW [] synonym: "negative regulation of NOS2 synthase biosynthetic process" NARROW [] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process [Term] id: GO:0051775 name: response to redox state namespace: biological_process alt_id: GO:0006980 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] synonym: "redox signal response" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051776 name: detection of redox state namespace: biological_process def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] synonym: "redox sensing" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051775 ! response to redox state [Term] id: GO:0051777 name: ent-kaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79] synonym: "ent-kaurenoic acid oxidase activity" EXACT [] xref: MetaCyc:1.14.13.79-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051778 name: ent-7-alpha-hydroxykaurenoate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. xref: MetaCyc:RXN1F-160 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051779 name: gibberellin 12-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. synonym: "GA12-aldehyde oxidase activity" EXACT [] xref: MetaCyc:RXN1F-161 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0051780 name: behavioral response to nutrient namespace: biological_process def: "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] synonym: "behavioural response to nutrient" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0007584 ! response to nutrient [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051301 ! cell division relationship: positively_regulates GO:0051301 ! cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051301 ! cell division relationship: negatively_regulates GO:0051301 ! cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000280 ! nuclear division relationship: regulates GO:0000280 ! nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000280 ! nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000280 ! nuclear division relationship: positively_regulates GO:0000280 ! nuclear division [Term] id: GO:0051786 name: all-trans-retinol 13,14-reductase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23, RHEA:19193] synonym: "(13,14)-all-trans-retinol saturase activity" EXACT [] synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT [] synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT [] synonym: "retinol saturase activity" EXACT [EC:1.3.99.23] synonym: "RetSat activity" EXACT [EC:1.3.99.23] xref: EC:1.3.99.23 xref: KEGG_REACTION:R07163 xref: MetaCyc:1.3.99.23-RXN xref: Reactome:R-HSA-8956427 "RETSAT reduces atROL to at-13,14-dhROL" xref: RHEA:19193 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0051787 name: misfolded protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a misfolded protein." [GOC:ai] xref: Reactome:R-HSA-5324632 "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates" is_a: GO:0005515 ! protein binding [Term] id: GO:0051788 name: response to misfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators] is_a: GO:0035966 ! response to topologically incorrect protein [Term] id: GO:0051789 name: obsolete response to protein namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai] comment: This term was made obsolete because more specific terms exist. synonym: "response to protein" EXACT [] synonym: "response to protein stimulus" EXACT [GOC:dos] is_obsolete: true consider: GO:0006986 consider: GO:0009725 consider: GO:0034097 consider: GO:0051788 consider: GO:0070848 [Term] id: GO:0051790 name: short-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6." [Wikipedia:Fatty_acid_metabolism] synonym: "short chain fatty acid biosynthesis" EXACT [] synonym: "short chain fatty acid biosynthetic process" EXACT [] synonym: "short-chain fatty acid anabolism" EXACT [] synonym: "short-chain fatty acid biosynthesis" EXACT [] synonym: "short-chain fatty acid formation" EXACT [] synonym: "short-chain fatty acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0051791 name: medium-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolisms] synonym: "medium chain fatty acid metabolic process" EXACT [] synonym: "medium chain fatty acid metabolism" EXACT [] synonym: "medium-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0051792 name: medium-chain fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolism] synonym: "medium chain fatty acid biosynthesis" EXACT [] synonym: "medium chain fatty acid biosynthetic process" EXACT [] synonym: "medium-chain fatty acid anabolism" EXACT [] synonym: "medium-chain fatty acid biosynthesis" EXACT [] synonym: "medium-chain fatty acid formation" EXACT [] synonym: "medium-chain fatty acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] id: GO:0051793 name: medium-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolism] synonym: "medium chain fatty acid catabolic process" EXACT [] synonym: "medium chain fatty acid catabolism" EXACT [] synonym: "medium-chain fatty acid breakdown" EXACT [] synonym: "medium-chain fatty acid catabolism" EXACT [] synonym: "medium-chain fatty acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] id: GO:0051794 name: regulation of timing of catagen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "regulation of catagen" RELATED [] is_a: GO:0048819 ! regulation of hair follicle maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042637 ! catagen relationship: regulates GO:0042637 ! catagen [Term] id: GO:0051795 name: positive regulation of timing of catagen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "activation of catagen" NARROW [] synonym: "positive regulation of catagen" RELATED [] synonym: "stimulation of catagen" NARROW [] synonym: "up regulation of catagen" RELATED [] synonym: "up-regulation of catagen" RELATED [] synonym: "upregulation of catagen" RELATED [] is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051794 ! regulation of timing of catagen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042637 ! catagen relationship: positively_regulates GO:0042637 ! catagen [Term] id: GO:0051796 name: negative regulation of timing of catagen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "down regulation of catagen" RELATED [] synonym: "down-regulation of catagen" RELATED [] synonym: "downregulation of catagen" RELATED [] synonym: "inhibition of catagen" NARROW [] synonym: "negative regulation of catagen" RELATED [] is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051794 ! regulation of timing of catagen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042637 ! catagen relationship: negatively_regulates GO:0042637 ! catagen [Term] id: GO:0051797 name: regulation of hair follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0045682 ! regulation of epidermis development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001942 ! hair follicle development relationship: regulates GO:0001942 ! hair follicle development [Term] id: GO:0051798 name: positive regulation of hair follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "activation of hair follicle development" NARROW [] synonym: "stimulation of hair follicle development" NARROW [] synonym: "up regulation of hair follicle development" EXACT [] synonym: "up-regulation of hair follicle development" EXACT [] synonym: "upregulation of hair follicle development" EXACT [] is_a: GO:0042635 ! positive regulation of hair cycle is_a: GO:0045684 ! positive regulation of epidermis development is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001942 ! hair follicle development relationship: positively_regulates GO:0001942 ! hair follicle development [Term] id: GO:0051799 name: negative regulation of hair follicle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai] synonym: "down regulation of hair follicle development" EXACT [] synonym: "down-regulation of hair follicle development" EXACT [] synonym: "downregulation of hair follicle development" EXACT [] synonym: "inhibition of hair follicle development" NARROW [] is_a: GO:0042636 ! negative regulation of hair cycle is_a: GO:0045683 ! negative regulation of epidermis development is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001942 ! hair follicle development relationship: negatively_regulates GO:0001942 ! hair follicle development [Term] id: GO:0051800 name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831] synonym: "PTEN activity" BROAD [] xref: Reactome:R-HSA-1676149 "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane" xref: Reactome:R-HSA-1676204 "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane" is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity [Term] id: GO:0051801 name: cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0051715 ! cytolysis in other organism is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0051802 name: regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0051710 ! regulation of cytolysis in other organism intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051803 name: negative regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "negative regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0051713 ! negative regulation of cytolysis in other organism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction relationship: negatively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051804 name: positive regulation of cytolysis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "positive regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] is_a: GO:0051714 ! positive regulation of cytolysis in other organism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0051814 name: movement in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "movement in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "movement within other organism during symbiotic interaction" EXACT [] is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0051815 name: migration in other organism involved in symbiotic interaction namespace: biological_process def: "The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "migration in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "migration within other organism during symbiotic interaction" RELATED [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction [Term] id: GO:0051816 name: acquisition of nutrients from other organism during symbiotic interaction namespace: biological_process def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] is_a: GO:0044403 ! symbiotic process [Term] id: GO:0051817 name: modification of morphology or physiology of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW [] synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW [] synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW [] is_a: GO:0035821 ! modification of morphology or physiology of other organism [Term] id: GO:0051818 name: disruption of cells of other organism involved in symbiotic interaction namespace: biological_process def: "A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc] synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0044364 ! disruption of cells of other organism is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0051819 name: induction by symbiont of tumor or growth in host namespace: biological_process alt_id: GO:0044005 alt_id: GO:0044006 alt_id: GO:0051820 def: "The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic." [GOC:pg] synonym: "induction by symbiont in host of tumor, nodule, or growth" RELATED [] synonym: "induction by symbiont in host of tumor, nodule, or growth containing transformed cells" RELATED [] synonym: "induction by symbiont of nodulation, tumor or growth in host" RELATED [] synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction" RELATED [] synonym: "induction of tumor, nodule, or growth in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "induction of tumor, nodule, or growth in other organism involved in symbiotic interaction" RELATED [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0051821 name: dissemination or transmission of organism from other organism involved in symbiotic interaction namespace: biological_process def: "The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc] synonym: "dissemination or transmission of organism from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0051822 name: dissemination or transmission of organism from other organism by vector involved in symbiotic interaction namespace: biological_process def: "The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc] synonym: "dissemination or transmission of organism from other organism by vector during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0051821 ! dissemination or transmission of organism from other organism involved in symbiotic interaction [Term] id: GO:0051823 name: regulation of synapse structural plasticity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123] synonym: "regulation of synaptic structural plasticity" EXACT [] is_a: GO:0050807 ! regulation of synapse organization [Term] id: GO:0051826 name: negative regulation of synapse structural plasticity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai] synonym: "down regulation of synapse structural plasticity" EXACT [] synonym: "down-regulation of synapse structural plasticity" EXACT [] synonym: "downregulation of synapse structural plasticity" EXACT [] synonym: "inhibition of synapse structural plasticity" NARROW [] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051823 ! regulation of synapse structural plasticity [Term] id: GO:0051827 name: obsolete growth or development on or near surface of other organism during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153' and 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'. synonym: "growth or development on or near surface of other organism during symbiotic interaction" EXACT [] is_obsolete: true consider: GO:0044110 consider: GO:0044111 [Term] id: GO:0051831 name: obsolete growth or development in other organism during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth in other organism during symbiotic interaction ; GO:0044112' and 'development in other organism during symbiotic interaction ; GO:0044113'. synonym: "growth or development in other organism during symbiotic interaction" EXACT [] synonym: "growth or development within other organism during symbiotic interaction" EXACT [] synonym: "invasive growth" BROAD [] is_obsolete: true consider: GO:0044113 consider: GO:0044117 [Term] id: GO:0051835 name: positive regulation of synapse structural plasticity namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai] synonym: "activation of synapse structural plasticity" NARROW [] synonym: "stimulation of synapse structural plasticity" NARROW [] synonym: "up regulation of synapse structural plasticity" EXACT [] synonym: "up-regulation of synapse structural plasticity" EXACT [] synonym: "upregulation of synapse structural plasticity" EXACT [] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051823 ! regulation of synapse structural plasticity [Term] id: GO:0051838 name: cytolysis by host of symbiont cells namespace: biological_process def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction is_a: GO:0051873 ! killing by host of symbiont cells relationship: has_part GO:0052337 ! modification by host of symbiont membrane [Term] id: GO:0051839 name: regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells [Term] id: GO:0051840 name: negative regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] synonym: "down regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "downregulation by host of cytolysis of symbiont cells" EXACT [] synonym: "inhibition by host of cytolysis of symbiont cells" NARROW [] is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells [Term] id: GO:0051841 name: positive regulation by host of cytolysis of symbiont cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] synonym: "activation by host of cytolysis of symbiont cells" NARROW [] synonym: "stimulation by host of cytolysis of symbiont cells" NARROW [] synonym: "up regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT [] synonym: "upregulation by host of cytolysis of symbiont cells" EXACT [] is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells [Term] id: GO:0051842 name: obsolete evasion or tolerance of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. synonym: "evasion or tolerance of symbiont immune response" EXACT [] synonym: "immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051843 name: obsolete evasion or tolerance of symbiont defense response namespace: biological_process def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "evasion of symbiont defence response" EXACT [] synonym: "evasion or tolerance of symbiont defense response" EXACT [] is_obsolete: true [Term] id: GO:0051844 name: translocation of peptides or proteins into symbiont namespace: biological_process def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "transport of peptides or proteins into symbiont" EXACT [] is_a: GO:0051862 ! translocation of molecules into symbiont [Term] id: GO:0051845 name: obsolete passive evasion of symbiont immune response namespace: biological_process def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "passive evasion of symbiont immune response" EXACT [] synonym: "passive immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051846 name: obsolete active evasion of symbiont immune response namespace: biological_process def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active evasion of symbiont immune response" EXACT [] synonym: "active immune evasion" BROAD [] is_obsolete: true [Term] id: GO:0051847 name: obsolete active evasion of symbiont immune response via regulation of symbiont complement system namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active evasion of symbiont immune response via regulation of symbiont complement system" EXACT [] synonym: "active immune evasion via modulation of symbiont complement system" EXACT [] synonym: "active immune evasion via regulation of symbiont complement system" EXACT [] is_obsolete: true [Term] id: GO:0051848 name: obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active evasion of symbiont immune response via regulation of symbiont cytokine network" EXACT [] synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT [] synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT [] is_obsolete: true [Term] id: GO:0051849 name: obsolete active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation namespace: biological_process def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation" EXACT [] synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT [] synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT [] synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT [] synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT [] is_obsolete: true [Term] id: GO:0051850 name: acquisition of nutrients from symbiont namespace: biological_process def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0051851 name: modification by host of symbiont morphology or physiology namespace: biological_process def: "The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0051702 ! interaction with symbiont is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0051852 name: disruption by host of symbiont cells namespace: biological_process def: "Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0051853 name: obsolete induction in symbiont of tumor, nodule, or growth namespace: biological_process def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "induction in symbiont of tumor, nodule, or growth" EXACT [] is_obsolete: true [Term] id: GO:0051854 name: obsolete induction in symbiont of tumor, nodule, or growth containing transformed cells namespace: biological_process def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "induction in symbiont of tumor, nodule, or growth containing transformed cells" EXACT [] is_obsolete: true [Term] id: GO:0051857 name: obsolete growth or development of organism on or near symbiont surface namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of organism on or near symbiont surface ; GO:0044151' and 'development of organism on or near symbiont surface ; GO:0044150'. synonym: "growth or development of organism during interaction with symbiont" EXACT [] synonym: "growth or development of organism on or near symbiont surface" EXACT [] is_obsolete: true consider: GO:0044150 consider: GO:0044151 [Term] id: GO:0051858 name: obsolete avoidance of symbiont defenses namespace: biological_process def: "OBSOLETE. Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. See https://github.com/geneontology/go-ontology/issues/14862 is_obsolete: true [Term] id: GO:0051859 name: obsolete suppression of symbiont defenses namespace: biological_process def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. See https://github.com/geneontology/go-ontology/issues/14862 is_obsolete: true [Term] id: GO:0051860 name: obsolete evasion or tolerance of symbiont defenses namespace: biological_process def: "OBSOLETE. The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. See https://github.com/geneontology/go-ontology/issues/14862 is_obsolete: true [Term] id: GO:0051861 name: glycolipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1] is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0051862 name: translocation of molecules into symbiont namespace: biological_process def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "transport of molecules into symbiont" EXACT [] is_a: GO:0051702 ! interaction with symbiont [Term] id: GO:0051863 name: obsolete translocation of DNA into symbiont namespace: biological_process def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: This term was made obsolete because it does not represent a real process that exists in nature. synonym: "translocation of DNA into symbiont" EXACT [] is_obsolete: true [Term] id: GO:0051864 name: histone demethylase activity (H3-K36 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein." [PMID:16362057] synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT [] synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27] synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT [] synonym: "histone-lysine(H3-K36) demethylase activity" EXACT [] synonym: "JHDM1A activity" NARROW [EC:1.14.11.27] synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27] synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] xref: EC:1.14.11.27 xref: MetaCyc:RXN-8660 xref: MetaCyc:RXN-8661 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0070544 ! histone H3-K36 demethylation [Term] id: GO:0051865 name: protein autoubiquitination namespace: biological_process def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] synonym: "protein auto-ubiquitination" EXACT [] synonym: "protein auto-ubiquitinylation" EXACT [] synonym: "protein autoubiquitinylation" EXACT [] synonym: "protein self-ubiquitination" EXACT [] synonym: "protein self-ubiquitinylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0051866 name: general adaptation syndrome namespace: biological_process alt_id: GO:0051868 def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [http://www.onelook.com, PMID:14847556, Wikipedia:General_adaptation_syndrome] synonym: "general adaptation syndrome, physiological process" EXACT [] synonym: "general adaptation syndrome, physiological response" EXACT [] synonym: "physiological process during general adaptation syndrome" EXACT [] synonym: "physiological response during general adaptation syndrome" EXACT [] is_a: GO:0033555 ! multicellular organismal response to stress [Term] id: GO:0051867 name: general adaptation syndrome, behavioral process namespace: biological_process def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai] synonym: "behavioral process during general adaptation syndrome" EXACT [] synonym: "behavioral response during general adaptation syndrome" EXACT [] synonym: "behavioural process during general adaptation syndrome" EXACT [] synonym: "behavioural response during general adaptation syndrome" EXACT [] synonym: "general adaptation syndrome, behavioral response" EXACT [] synonym: "general adaptation syndrome, behavioural process" EXACT [] synonym: "general adaptation syndrome, behavioural response" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0051866 ! general adaptation syndrome [Term] id: GO:0051870 name: methotrexate binding namespace: molecular_function def: "Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln] is_a: GO:0008144 ! drug binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0033218 ! amide binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0051871 name: dihydrofolic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544] synonym: "DHF binding" RELATED [] synonym: "dihydrofolate binding" RELATED [] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0033218 ! amide binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0051872 name: sphingosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai] synonym: "(4E)-sphing-4-enine catabolic process" EXACT [] synonym: "(4E)-sphing-4-enine catabolism" EXACT [] synonym: "sphing-4-enine catabolic process" EXACT [] synonym: "sphing-4-enine catabolism" EXACT [] is_a: GO:0006670 ! sphingosine metabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0046521 ! sphingoid catabolic process [Term] id: GO:0051873 name: killing by host of symbiont cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0051852 ! disruption by host of symbiont cells is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0051874 name: sphinganine-1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0051875 name: pigment granule localization namespace: biological_process def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization relationship: part_of GO:0033059 ! cellular pigmentation [Term] id: GO:0051876 name: pigment granule dispersal namespace: biological_process def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh] is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051877 name: pigment granule aggregation in cell center namespace: biological_process def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh] is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051878 name: lateral element assembly namespace: biological_process def: "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007130 ! synaptonemal complex assembly [Term] id: GO:0051879 name: Hsp90 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] synonym: "Hsp90 binding" EXACT [] synonym: "Hsp90 class protein binding" EXACT [] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0051880 name: G-quadruplex DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530] synonym: "G quadruplex DNA binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:mah] synonym: "G quartet DNA binding" EXACT [GOC:mah] synonym: "G-DNA binding" EXACT [] synonym: "G-quartet binding" BROAD [GOC:mah] synonym: "G-quartet DNA binding" EXACT [GOC:mah] synonym: "quadruplex DNA binding" EXACT [] synonym: "tetraplex DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0051881 name: regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051882 name: mitochondrial depolarization namespace: biological_process def: "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level." [Wikipedia:Depolarization, Wikipedia:Mitochondrion] synonym: "mitochondria depolarization" EXACT [] synonym: "mitochondrial depolarisation" EXACT [] synonym: "mitochondrial membrane depolarization" EXACT [] synonym: "mitochondrion depolarization" EXACT [] is_a: GO:0051881 ! regulation of mitochondrial membrane potential is_a: GO:0051899 ! membrane depolarization intersection_of: GO:0051899 ! membrane depolarization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0051883 name: killing of cells in other organism involved in symbiotic interaction namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0031640 ! killing of cells of other organism is_a: GO:0051818 ! disruption of cells of other organism involved in symbiotic interaction [Term] id: GO:0051884 name: regulation of timing of anagen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "regulation of anagen" RELATED [] is_a: GO:0048819 ! regulation of hair follicle maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042640 ! anagen relationship: regulates GO:0042640 ! anagen [Term] id: GO:0051885 name: positive regulation of timing of anagen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "activation of anagen" NARROW [] synonym: "positive regulation of anagen" RELATED [] synonym: "stimulation of anagen" NARROW [] synonym: "up regulation of anagen" RELATED [] synonym: "up-regulation of anagen" RELATED [] synonym: "upregulation of anagen" RELATED [] is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051884 ! regulation of timing of anagen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042640 ! anagen relationship: positively_regulates GO:0042640 ! anagen [Term] id: GO:0051886 name: negative regulation of timing of anagen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "down regulation of anagen" RELATED [] synonym: "down-regulation of anagen" RELATED [] synonym: "downregulation of anagen" RELATED [] synonym: "inhibition of anagen" NARROW [] synonym: "negative regulation of anagen" RELATED [] is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051884 ! regulation of timing of anagen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042640 ! anagen relationship: negatively_regulates GO:0042640 ! anagen [Term] id: GO:0051887 name: regulation of timing of exogen namespace: biological_process def: "Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "regulation of exogen" RELATED [] is_a: GO:0048819 ! regulation of hair follicle maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042638 ! exogen relationship: regulates GO:0042638 ! exogen [Term] id: GO:0051888 name: positive regulation of timing of exogen namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "activation of exogen" NARROW [] synonym: "positive regulation of exogen" RELATED [] synonym: "stimulation of exogen" NARROW [] synonym: "up regulation of exogen" RELATED [] synonym: "up-regulation of exogen" RELATED [] synonym: "upregulation of exogen" RELATED [] is_a: GO:0048818 ! positive regulation of hair follicle maturation is_a: GO:0051887 ! regulation of timing of exogen intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042638 ! exogen relationship: positively_regulates GO:0042638 ! exogen [Term] id: GO:0051889 name: negative regulation of timing of exogen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] synonym: "down regulation of exogen" RELATED [] synonym: "down-regulation of exogen" RELATED [] synonym: "downregulation of exogen" RELATED [] synonym: "inhibition of exogen" NARROW [] synonym: "negative regulation of exogen" RELATED [] is_a: GO:0048817 ! negative regulation of hair follicle maturation is_a: GO:0051887 ! regulation of timing of exogen intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042638 ! exogen relationship: negatively_regulates GO:0042638 ! exogen [Term] id: GO:0051890 name: regulation of cardioblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] is_a: GO:1905207 ! regulation of cardiocyte differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010002 ! cardioblast differentiation relationship: regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051891 name: positive regulation of cardioblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "activation of cardioblast differentiation" NARROW [] synonym: "stimulation of cardioblast differentiation" NARROW [] synonym: "up regulation of cardioblast differentiation" EXACT [] synonym: "up-regulation of cardioblast differentiation" EXACT [] synonym: "upregulation of cardioblast differentiation" EXACT [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010002 ! cardioblast differentiation relationship: positively_regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051892 name: negative regulation of cardioblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "down regulation of cardioblast differentiation" EXACT [] synonym: "down-regulation of cardioblast differentiation" EXACT [] synonym: "downregulation of cardioblast differentiation" EXACT [] synonym: "inhibition of cardioblast differentiation" NARROW [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010002 ! cardioblast differentiation relationship: negatively_regulates GO:0010002 ! cardioblast differentiation [Term] id: GO:0051893 name: regulation of focal adhesion assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] synonym: "regulation of adhesion plaque assembly" RELATED [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0090109 ! regulation of cell-substrate junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048041 ! focal adhesion assembly relationship: regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051894 name: positive regulation of focal adhesion assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] synonym: "activation of focal adhesion formation" NARROW [] synonym: "stimulation of focal adhesion formation" NARROW [] synonym: "up regulation of focal adhesion formation" EXACT [] synonym: "up-regulation of focal adhesion formation" EXACT [] synonym: "upregulation of focal adhesion formation" EXACT [] is_a: GO:0001954 ! positive regulation of cell-matrix adhesion is_a: GO:0051893 ! regulation of focal adhesion assembly is_a: GO:0150117 ! positive regulation of cell-substrate junction organization is_a: GO:1901890 ! positive regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048041 ! focal adhesion assembly relationship: positively_regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051895 name: negative regulation of focal adhesion assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] synonym: "down regulation of focal adhesion formation" EXACT [] synonym: "down-regulation of focal adhesion formation" EXACT [] synonym: "downregulation of focal adhesion formation" EXACT [] synonym: "inhibition of focal adhesion formation" NARROW [] is_a: GO:0001953 ! negative regulation of cell-matrix adhesion is_a: GO:0051893 ! regulation of focal adhesion assembly is_a: GO:0150118 ! negative regulation of cell-substrate junction organization is_a: GO:1901889 ! negative regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048041 ! focal adhesion assembly relationship: negatively_regulates GO:0048041 ! focal adhesion assembly [Term] id: GO:0051896 name: regulation of protein kinase B signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "regulation of AKT signaling cascade" RELATED [] synonym: "regulation of AKT signalling cascade" RELATED [] synonym: "regulation of PKB signaling cascade" RELATED [] synonym: "regulation of PKB signalling cascade" RELATED [] synonym: "regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "regulation of protein kinase B signalling cascade" RELATED [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043491 ! protein kinase B signaling relationship: regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051897 name: positive regulation of protein kinase B signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "activation of protein kinase B signaling cascade" NARROW [] synonym: "positive regulation of AKT signaling cascade" RELATED [] synonym: "positive regulation of AKT signalling cascade" EXACT [] synonym: "positive regulation of PKB signaling cascade" EXACT [] synonym: "positive regulation of PKB signalling cascade" RELATED [] synonym: "positive regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of protein kinase B signalling cascade" RELATED [] synonym: "stimulation of protein kinase B signaling cascade" NARROW [] synonym: "up regulation of protein kinase B signaling cascade" RELATED [] synonym: "up-regulation of protein kinase B signaling cascade" RELATED [] synonym: "upregulation of protein kinase B signaling cascade" RELATED [] is_a: GO:0051896 ! regulation of protein kinase B signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043491 ! protein kinase B signaling relationship: positively_regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051898 name: negative regulation of protein kinase B signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] synonym: "down regulation of protein kinase B signaling cascade" RELATED [] synonym: "down-regulation of protein kinase B signaling cascade" RELATED [] synonym: "downregulation of protein kinase B signaling cascade" RELATED [] synonym: "inhibition of protein kinase B signaling cascade" NARROW [] synonym: "negative regulation of AKT signaling cascade" RELATED [] synonym: "negative regulation of AKT signalling cascade" EXACT [] synonym: "negative regulation of PKB signaling cascade" EXACT [] synonym: "negative regulation of PKB signalling cascade" RELATED [] synonym: "negative regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of protein kinase B signalling cascade" RELATED [] is_a: GO:0051896 ! regulation of protein kinase B signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043491 ! protein kinase B signaling relationship: negatively_regulates GO:0043491 ! protein kinase B signaling [Term] id: GO:0051899 name: membrane depolarization namespace: biological_process def: "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dh, Wikipedia:Depolarization] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0051900 name: regulation of mitochondrial depolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0051881 ! regulation of mitochondrial membrane potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051882 ! mitochondrial depolarization relationship: regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051901 name: positive regulation of mitochondrial depolarization namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "activation of mitochondrial depolarization" NARROW [] synonym: "stimulation of mitochondrial depolarization" NARROW [] synonym: "up regulation of mitochondrial depolarization" EXACT [] synonym: "up-regulation of mitochondrial depolarization" EXACT [] synonym: "upregulation of mitochondrial depolarization" EXACT [] is_a: GO:0051900 ! regulation of mitochondrial depolarization is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051882 ! mitochondrial depolarization relationship: positively_regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051902 name: negative regulation of mitochondrial depolarization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] synonym: "down regulation of mitochondrial depolarization" EXACT [] synonym: "down-regulation of mitochondrial depolarization" EXACT [] synonym: "downregulation of mitochondrial depolarization" EXACT [] synonym: "inhibition of mitochondrial depolarization" NARROW [] is_a: GO:0051900 ! regulation of mitochondrial depolarization is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051882 ! mitochondrial depolarization relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization [Term] id: GO:0051903 name: S-(hydroxymethyl)glutathione dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284] synonym: "ADH3 activity" NARROW [EC:1.1.1.284] synonym: "chi-ADH activity" NARROW [EC:1.1.1.284] synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "FDH activity" RELATED [EC:1.1.1.284] synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284] synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284] synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "GS-FDH activity" EXACT [EC:1.1.1.284] synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284] xref: EC:1.1.1.284 xref: KEGG_REACTION:R06983 xref: KEGG_REACTION:R07140 xref: MetaCyc:RXN-2962 xref: Reactome:R-HSA-5692237 "ADH5 oxidises S-HMGSH to S-FGSH" xref: RHEA:19981 xref: RHEA:19985 xref: UM-BBD_reactionID:r1146 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0051904 name: pigment granule transport namespace: biological_process def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pigment granule translocation" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0051875 ! pigment granule localization is_a: GO:0051905 ! establishment of pigment granule localization [Term] id: GO:0051905 name: establishment of pigment granule localization namespace: biological_process def: "The directed movement of a pigment granule to a specific location." [GOC:ai] synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0051875 ! pigment granule localization [Term] id: GO:0051906 name: maintenance of pigment granule location namespace: biological_process def: "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051655 ! maintenance of vesicle location relationship: part_of GO:0051875 ! pigment granule localization [Term] id: GO:0051907 name: S-(hydroxymethyl)glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione." [EC:4.4.1.22, RHEA:22488] synonym: "Gfa" RELATED [EC:4.4.1.22] synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT [] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22] synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22] xref: EC:4.4.1.22 xref: KEGG_REACTION:R06982 xref: MetaCyc:RXN-2961 xref: RHEA:22488 xref: UM-BBD_reactionID:r1145 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0051908 name: double-stranded DNA 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] synonym: "double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity [Term] id: GO:0051909 name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN] synonym: "3-hydroxypropenoate dehydratase activity" EXACT [] synonym: "acetylenecarboxylate hydratase activity" BROAD [] synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] synonym: "alkynoate hydratase activity" BROAD [] xref: EC:4.2.1.27 xref: RHEA:17957 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0051911 name: Methanosarcina-phenazine hydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3] synonym: "methanophenazine hydrogenase activity" EXACT [] synonym: "methylviologen-reducing hydrogenase activity" EXACT [] xref: EC:1.12.98.3 xref: MetaCyc:RXN-7733 xref: RHEA:24436 is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors [Term] id: GO:0051912 name: CoB--CoM heterodisulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1] synonym: "CoB-CoM heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT [] synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1] synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] synonym: "heterodisulfide reductase activity" BROAD [] synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1] xref: EC:1.8.98.1 xref: MetaCyc:1.8.98.1-RXN xref: RHEA:18085 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0051913 name: regulation of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "regulation of synaptic plasticity by drug" NARROW [] is_a: GO:0048167 ! regulation of synaptic plasticity relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0051914 name: positive regulation of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "activation of synaptic plasticity by chemical substance" NARROW [] synonym: "positive regulation of synaptic plasticity by drug" NARROW [] synonym: "stimulation of synaptic plasticity by chemical substance" NARROW [] synonym: "up regulation of synaptic plasticity by chemical substance" EXACT [] synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT [] synonym: "upregulation of synaptic plasticity by chemical substance" EXACT [] is_a: GO:0031915 ! positive regulation of synaptic plasticity is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance [Term] id: GO:0051915 name: induction of synaptic plasticity by chemical substance namespace: biological_process def: "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] synonym: "activation of synaptic plasticity by chemical substance" EXACT [] synonym: "activation of synaptic plasticity by drug" NARROW [] synonym: "induction of synaptic plasticity by drug" NARROW [] is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance [Term] id: GO:0051916 name: granulocyte colony-stimulating factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with granulocyte colony-stimulating factor, G-CSF." [GOC:ai] synonym: "G-CSF binding" EXACT [] synonym: "granulocyte colony stimulating factor binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0051917 name: regulation of fibrinolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] is_a: GO:0030193 ! regulation of blood coagulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042730 ! fibrinolysis relationship: regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051918 name: negative regulation of fibrinolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] synonym: "down regulation of fibrinolysis" EXACT [] synonym: "down-regulation of fibrinolysis" EXACT [] synonym: "downregulation of fibrinolysis" EXACT [] synonym: "inhibition of fibrinolysis" NARROW [] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051917 ! regulation of fibrinolysis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042730 ! fibrinolysis relationship: negatively_regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051919 name: positive regulation of fibrinolysis namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] synonym: "activation of fibrinolysis" NARROW [] synonym: "stimulation of fibrinolysis" NARROW [] synonym: "up regulation of fibrinolysis" EXACT [] synonym: "up-regulation of fibrinolysis" EXACT [] synonym: "upregulation of fibrinolysis" EXACT [] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051917 ! regulation of fibrinolysis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042730 ! fibrinolysis relationship: positively_regulates GO:0042730 ! fibrinolysis [Term] id: GO:0051920 name: peroxiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15, RHEA:10008] comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism. synonym: "AhpC activity" NARROW [] synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] synonym: "PRDX activity" EXACT [] synonym: "Prx activity" EXACT [] synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15] xref: EC:1.11.1.15 xref: MetaCyc:1.11.1.15-RXN xref: Reactome:R-HSA-1222431 "Peroxynitrite is reduced to nitrite by AhpC" xref: Reactome:R-HSA-1222755 "Peroxynitrite is reduced to nitrite by Tpx" xref: Reactome:R-HSA-1500804 "Peroxynitrite is reduced by AhpE" xref: RHEA:10008 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0051921 name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate." [EC:6.3.5.10, RHEA:23256] synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT [] synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT [] synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10] synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT [] synonym: "CobQ activity" BROAD [] synonym: "cobyric acid synthase activity" RELATED [] xref: EC:6.3.5.10 xref: KEGG_REACTION:R05225 xref: MetaCyc:R345-RXN xref: RHEA:23256 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0051922 name: cholesterol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293] xref: EC:2.8.2 is_a: GO:0004027 ! alcohol sulfotransferase activity [Term] id: GO:0051923 name: sulfation namespace: biological_process def: "The addition of a sulfate group to a molecule." [http://www.onelook.com] synonym: "phase II metabolism" BROAD [PMID:20056724] synonym: "sulfonation" EXACT [] synonym: "sulfur addition" EXACT [] synonym: "sulphation" EXACT [] synonym: "sulphur addition" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0051924 name: regulation of calcium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "regulation of calcium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006816 ! calcium ion transport relationship: regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051925 name: obsolete regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT [] is_obsolete: true consider: GO:0005245 [Term] id: GO:0051926 name: negative regulation of calcium ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of calcium ion transport" EXACT [] synonym: "down-regulation of calcium ion transport" EXACT [] synonym: "downregulation of calcium ion transport" EXACT [] synonym: "inhibition of calcium ion transport" NARROW [] synonym: "negative regulation of calcium transport" EXACT [] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006816 ! calcium ion transport relationship: negatively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051927 name: obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "negative regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED [] is_obsolete: true consider: GO:0005245 [Term] id: GO:0051928 name: positive regulation of calcium ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of calcium ion transport" NARROW [] synonym: "positive regulation of calcium transport" EXACT [] synonym: "stimulation of calcium ion transport" NARROW [] synonym: "up regulation of calcium ion transport" EXACT [] synonym: "up-regulation of calcium ion transport" EXACT [] synonym: "upregulation of calcium ion transport" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006816 ! calcium ion transport relationship: positively_regulates GO:0006816 ! calcium ion transport [Term] id: GO:0051929 name: obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "positive regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT [] synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW [] synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT [] is_obsolete: true consider: GO:0005245 [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019233 ! sensory perception of pain relationship: regulates GO:0019233 ! sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007600 ! sensory perception relationship: regulates GO:0007600 ! sensory perception [Term] id: GO:0051932 name: synaptic transmission, GABAergic namespace: biological_process def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030] synonym: "synaptic transmission, GABA mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0051933 name: amino acid neurotransmitter reuptake namespace: biological_process def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "amino acid neurotransmitter import into glial cell" NARROW [] synonym: "amino acid neurotransmitter import into neuron" NARROW [] synonym: "amino acid neurotransmitter recycling" BROAD [] synonym: "amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0043090 ! amino acid import is_a: GO:0098810 ! neurotransmitter reuptake [Term] id: GO:0051934 name: catecholamine uptake involved in synaptic transmission namespace: biological_process def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "catecholamine neurotransmitter import into glial cell" NARROW [] synonym: "catecholamine neurotransmitter import into neuron" NARROW [] synonym: "catecholamine neurotransmitter recycling" BROAD [] synonym: "catecholamine neurotransmitter reuptake" EXACT [] synonym: "catecholamine reuptake during transmission of nerve impulse" RELATED [] synonym: "catecholamine uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0090493 ! catecholamine uptake is_a: GO:0098810 ! neurotransmitter reuptake [Term] id: GO:0051935 name: glutamate reuptake namespace: biological_process def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387, Wikipedia:Glutamate_transporter] synonym: "glutamate import into glial cell" NARROW [] synonym: "glutamate import into neuron" NARROW [] synonym: "glutamate recycling" BROAD [] synonym: "glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "L-glutamate reuptake" EXACT [] synonym: "L-glutamate uptake during transmission of nerve impulse" RELATED [] synonym: "L-glutamate uptake involved in synaptic transmission" EXACT [] is_a: GO:0051933 ! amino acid neurotransmitter reuptake is_a: GO:0098712 ! L-glutamate import across plasma membrane [Term] id: GO:0051936 name: gamma-aminobutyric acid reuptake namespace: biological_process def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] synonym: "GABA import into glial cell" NARROW [] synonym: "GABA import into neuron" NARROW [] synonym: "GABA recycling" BROAD [] synonym: "GABA reuptake" EXACT [] synonym: "gamma-aminobutyric acid import into glial cell" NARROW [] synonym: "gamma-aminobutyric acid import into neuron" NARROW [] synonym: "gamma-aminobutyric acid recycling" BROAD [] synonym: "gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "gamma-aminobutyric acid uptake involved in synaptic transmission" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0051933 ! amino acid neurotransmitter reuptake [Term] id: GO:0051937 name: catecholamine transport namespace: biological_process def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0051938 name: L-glutamate import namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015893 ! drug transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0051939 name: gamma-aminobutyric acid import namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] synonym: "4-aminobutyrate import" EXACT [] synonym: "GABA import" EXACT [] synonym: "gamma-aminobutyrate import" EXACT [] synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0051940 name: regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission relationship: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051941 name: regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051933 ! amino acid neurotransmitter reuptake relationship: regulates GO:0051933 ! amino acid neurotransmitter reuptake [Term] id: GO:0051942 name: negative regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "down regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "downregulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "inhibition of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "negative regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake relationship: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake [Term] id: GO:0051943 name: positive regulation of amino acid uptake involved in synaptic transmission namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] synonym: "activation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT [] synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT [] synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] synonym: "upregulation of amino acid uptake during transmission of nerve impulse" RELATED [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake relationship: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake [Term] id: GO:0051944 name: positive regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "positive regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051945 name: negative regulation of catecholamine uptake involved in synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT [] synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT [] synonym: "negative regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission [Term] id: GO:0051946 name: regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "regulation of glutamate reuptake" EXACT [] synonym: "regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph] synonym: "regulation of L-glutamate reuptake" EXACT [] synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051935 ! glutamate reuptake relationship: regulates GO:0051935 ! glutamate reuptake [Term] id: GO:0051947 name: regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "regulation of GABA reuptake" EXACT [] synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051936 ! gamma-aminobutyric acid reuptake relationship: regulates GO:0051936 ! gamma-aminobutyric acid reuptake [Term] id: GO:0051948 name: negative regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of glutamate reuptake" EXACT [] synonym: "negative regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of glutamate uptake involved in conduction of nerve impulse" RELATED [GOC:dph] is_a: GO:0002037 ! negative regulation of L-glutamate import across plasma membrane is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051935 ! glutamate reuptake relationship: negatively_regulates GO:0051935 ! glutamate reuptake [Term] id: GO:0051949 name: negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "negative regulation of GABA reuptake" EXACT [] synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake [Term] id: GO:0051950 name: positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT [] synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] synonym: "positive regulation of GABA reuptake" EXACT [] synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT [] synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT [] synonym: "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake [Term] id: GO:0051951 name: positive regulation of glutamate uptake involved in transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "positive regulation of glutamate reuptake" EXACT [] synonym: "positive regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW [] synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT [] is_a: GO:0002038 ! positive regulation of L-glutamate import across plasma membrane is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051935 ! glutamate reuptake relationship: positively_regulates GO:0051935 ! glutamate reuptake [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015837 ! amine transport relationship: regulates GO:0015837 ! amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015837 ! amine transport relationship: negatively_regulates GO:0015837 ! amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015837 ! amine transport relationship: positively_regulates GO:0015837 ! amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0044070 ! regulation of anion transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006865 ! amino acid transport relationship: regulates GO:0006865 ! amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903792 ! negative regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006865 ! amino acid transport relationship: negatively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903793 ! positive regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006865 ! amino acid transport relationship: positively_regulates GO:0006865 ! amino acid transport [Term] id: GO:0051958 name: methotrexate transport namespace: biological_process def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport [Term] id: GO:0051959 name: dynein light intermediate chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light intermediate chain of the dynein complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007399 ! nervous system development relationship: regulates GO:0007399 ! nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007399 ! nervous system development relationship: negatively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007399 ! nervous system development relationship: positively_regulates GO:0007399 ! nervous system development [Term] id: GO:0051963 name: regulation of synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] subset: goslim_synapse synonym: "regulation of synapse biogenesis" EXACT [] synonym: "regulation of synaptogenesis" EXACT [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007416 ! synapse assembly relationship: regulates GO:0007416 ! synapse assembly [Term] id: GO:0051964 name: negative regulation of synapse assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "down regulation of synapse assembly" EXACT [] synonym: "down-regulation of synapse assembly" EXACT [] synonym: "downregulation of synapse assembly" EXACT [] synonym: "inhibition of synapse assembly" NARROW [] synonym: "negative regulation of synapse biogenesis" EXACT [] synonym: "negative regulation of synaptogenesis" EXACT [] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007416 ! synapse assembly relationship: negatively_regulates GO:0007416 ! synapse assembly [Term] id: GO:0051965 name: positive regulation of synapse assembly namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "activation of synapse assembly" NARROW [] synonym: "positive regulation of synapse biogenesis" EXACT [] synonym: "positive regulation of synaptogenesis" EXACT [] synonym: "stimulation of synapse assembly" NARROW [] synonym: "up regulation of synapse assembly" EXACT [] synonym: "up-regulation of synapse assembly" EXACT [] synonym: "upregulation of synapse assembly" EXACT [] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007416 ! synapse assembly relationship: positively_regulates GO:0007416 ! synapse assembly [Term] id: GO:0051966 name: regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035249 ! synaptic transmission, glutamatergic relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051967 name: negative regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051968 name: positive regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "activation of synaptic transmission, glutamatergic" NARROW [] synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic [Term] id: GO:0051969 name: regulation of transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019226 ! transmission of nerve impulse relationship: regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051970 name: negative regulation of transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "down regulation of transmission of nerve impulse" EXACT [] synonym: "down-regulation of transmission of nerve impulse" EXACT [] synonym: "downregulation of transmission of nerve impulse" EXACT [] synonym: "inhibition of transmission of nerve impulse" NARROW [] synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019226 ! transmission of nerve impulse relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051971 name: positive regulation of transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "activation of transmission of nerve impulse" NARROW [] synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of transmission of nerve impulse" NARROW [] synonym: "up regulation of transmission of nerve impulse" EXACT [] synonym: "up-regulation of transmission of nerve impulse" EXACT [] synonym: "upregulation of transmission of nerve impulse" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019226 ! transmission of nerve impulse relationship: positively_regulates GO:0019226 ! transmission of nerve impulse [Term] id: GO:0051972 name: regulation of telomerase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai] synonym: "telomerase regulator" EXACT [] is_a: GO:0051338 ! regulation of transferase activity is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003720 ! telomerase activity relationship: regulates GO:0003720 ! telomerase activity [Term] id: GO:0051973 name: positive regulation of telomerase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] synonym: "activation of telomerase activity" NARROW [] synonym: "stimulation of telomerase activity" NARROW [] synonym: "telomerase activator" RELATED [] synonym: "up regulation of telomerase activity" EXACT [] synonym: "up-regulation of telomerase activity" EXACT [] synonym: "upregulation of telomerase activity" EXACT [] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:0051972 ! regulation of telomerase activity is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003720 ! telomerase activity relationship: positively_regulates GO:0003720 ! telomerase activity [Term] id: GO:0051974 name: negative regulation of telomerase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] synonym: "down regulation of telomerase activity" EXACT [] synonym: "down-regulation of telomerase activity" EXACT [] synonym: "downregulation of telomerase activity" EXACT [] synonym: "inhibition of telomerase activity" NARROW [] synonym: "telomerase inhibitor" RELATED [] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:0051972 ! regulation of telomerase activity is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003720 ! telomerase activity relationship: negatively_regulates GO:0003720 ! telomerase activity [Term] id: GO:0051975 name: lysine biosynthetic process via alpha-aminoadipate and saccharopine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY] synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [] synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [] xref: MetaCyc:LYSINE-AMINOAD-PWY is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid [Term] id: GO:0051976 name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081] synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] xref: MetaCyc:PWY-3081 is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid [Term] id: GO:0051977 name: lysophospholipid transport namespace: biological_process def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] is_a: GO:0015914 ! phospholipid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0051978 name: lysophospholipid:sodium symporter activity namespace: molecular_function def: "Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] comment: Changed label, see https://github.com/geneontology/go-ontology/issues/17207. synonym: "lysophospholipid transporter activity" BROAD [] is_a: GO:0005436 ! sodium:phosphate symporter activity is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0051977 ! lysophospholipid transport [Term] id: GO:0051979 name: alginic acid acetylation namespace: biological_process def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg] synonym: "alginate acetylation" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process [Term] id: GO:0051980 name: iron-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai, PMID:20625001] synonym: "Fe-NA chelate transporter activity" EXACT [] is_a: GO:0015603 ! iron chelate transmembrane transporter activity [Term] id: GO:0051981 name: copper chelate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0051982 name: copper-nicotianamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai] synonym: "Cu-NA chelate transporter activity" EXACT [] is_a: GO:0051981 ! copper chelate transmembrane transporter activity [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007059 ! chromosome segregation relationship: regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007059 ! chromosome segregation relationship: positively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007059 ! chromosome segregation relationship: negatively_regulates GO:0007059 ! chromosome segregation [Term] id: GO:0051986 name: negative regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051987 name: positive regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW [] synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW [] synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT [] synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT [] is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051988 name: regulation of attachment of spindle microtubules to kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore [Term] id: GO:0051989 name: coproporphyrinogen dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.98.3] synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.98.3] synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.98.3] synonym: "HemN" RELATED [EC:1.3.98.3] synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT [] synonym: "radical SAM enzyme activity" RELATED [EC:1.3.98.3] xref: EC:1.3.98.3 xref: MetaCyc:HEMN-RXN xref: RHEA:15425 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0051990 name: (R)-2-hydroxyglutarate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.39, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] xref: EC:1.1.99.39 xref: Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2" xref: Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0051991 name: UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP." [MetaCyc:NACGLCTRANS-RXN] comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. xref: EC:2.4.1.227 xref: MetaCyc:NACGLCTRANS-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity created_by: gwg creation_date: 2010-07-06T11:53:19Z [Term] id: GO:0051992 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl xref: EC:2.7.8.13 xref: MetaCyc:PHOSNACMURPENTATRANS-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups created_by: gwg creation_date: 2010-07-06T12:10:01Z [Term] id: GO:0051993 name: abscisic acid glucose ester beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose." [PMID:16990135] synonym: "ABA-GE beta-glucosidase activity" EXACT [] xref: EC:3.2.1.175 xref: MetaCyc:RXN-11469 is_a: GO:0008422 ! beta-glucosidase activity created_by: gwg creation_date: 2010-07-16T02:16:59Z [Term] id: GO:0051994 name: P-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 is_a: GO:0008168 ! methyltransferase activity created_by: gwg creation_date: 2010-07-16T04:39:34Z [Term] id: GO:0051995 name: Se-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule." [GOC:ai] is_a: GO:0008168 ! methyltransferase activity created_by: gwg creation_date: 2010-07-16T04:48:08Z [Term] id: GO:0051996 name: squalene synthase activity namespace: molecular_function def: "Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:RXN66-281 is_a: GO:0004311 ! farnesyltranstransferase activity created_by: gwg creation_date: 2010-07-16T05:10:24Z [Term] id: GO:0051997 name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201] synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity" EXACT [] synonym: "OHCU decarboxylase activity" EXACT [] xref: KEGG_REACTION:R06604 xref: MetaCyc:RXN-6201 is_a: GO:0016831 ! carboxy-lyase activity created_by: gwg creation_date: 2010-07-19T10:47:15Z [Term] id: GO:0051998 name: protein carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai] synonym: "protein carboxyl methyltransferase activity" EXACT [] is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0010340 ! carboxyl-O-methyltransferase activity created_by: gwg creation_date: 2010-07-20T09:23:00Z [Term] id: GO:0051999 name: mannosyl-inositol phosphorylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] synonym: "mannose inositol phosphoceramide biosynthetic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) biosynthetic process" EXACT [] synonym: "mannosyl-inositol phosphorylceramide anabolism" EXACT [] synonym: "mannosyl-inositol phosphorylceramide biosynthesis" EXACT [] synonym: "mannosyl-inositol phosphorylceramide formation" EXACT [] synonym: "mannosyl-inositol phosphorylceramide synthesis" EXACT [] synonym: "MIPC biosynthetic process" EXACT [] is_a: GO:0006675 ! mannosyl-inositol phosphorylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0008654 ! phospholipid biosynthetic process created_by: gwg creation_date: 2010-07-20T10:16:26Z [Term] id: GO:0052000 name: type IV pili-dependent aggregation namespace: biological_process def: "The formation of bacterial aggregates in liquid culture dependent on the presence of type IV pili." [GOC:ml] synonym: "auto-aggregation" BROAD [] synonym: "bfp-dependent aggregation" EXACT [] synonym: "bundle-forming fimbriae-dependent aggregation" EXACT [] synonym: "bundle-forming pili-dependent aggregation" EXACT [] synonym: "tfp-dependent aggregation" EXACT [] is_a: GO:0098630 ! aggregation of unicellular organisms [Term] id: GO:0052001 name: type IV pili-dependent localized adherence to host namespace: biological_process def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml] is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0052002 name: metabolism by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052003 name: suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052004 alt_id: GO:0052252 alt_id: GO:0052253 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "negative regulation of host SA-mediated defense response" EXACT [] synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT [] synonym: "suppression of host SA mediated defense response" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010113 ! negative regulation of systemic acquired resistance is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response is_a: GO:2001039 ! negative regulation of cellular response to drug relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052005 name: suppression by symbiont of host ethylene-mediated defense response namespace: biological_process alt_id: GO:0052070 alt_id: GO:0052254 alt_id: GO:0052268 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] synonym: "negative regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "suppression by organism of host ethylene-mediated defense response" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response [Term] id: GO:0052006 name: catabolism by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of substance in host" EXACT [] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052007 name: biosynthesis by symbiont of substance in host namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "biosynthesis by organism of substance in host" EXACT [] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction [Term] id: GO:0052008 name: disruption by symbiont of host cellular component namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of host cellular component by organism" EXACT [] synonym: "catabolism of host structural constituent by organism" EXACT [] synonym: "degradation of host cellular component by organism" EXACT [] synonym: "disassembly by organism of host cellular component" EXACT [] synonym: "disassembly by symbiont of host cellular component" RELATED [] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052368 ! disruption by organism of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052009 name: disruption by symbiont of host cell wall namespace: biological_process def: "A process carried out by a symbiont that breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "disassembly by symbiont of host cell wall" EXACT [] is_a: GO:0098933 ! disruption by symbiont of host cell envelope [Term] id: GO:0052010 name: catabolism by symbiont of host cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host cell wall cellulose" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052172 ! metabolism by symbiont of host cell wall cellulose is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall [Term] id: GO:0052011 name: catabolism by symbiont of host cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host cell wall pectin" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052179 ! metabolism by symbiont of host cell wall pectin is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall [Term] id: GO:0052012 name: catabolism by symbiont of host cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host cell wall chitin" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052178 ! metabolism by symbiont of host cell wall chitin is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction relationship: part_of GO:0052009 ! disruption by symbiont of host cell wall [Term] id: GO:0052013 name: catabolism by symbiont of host macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host macromolecule" EXACT [] is_a: GO:0052006 ! catabolism by symbiont of substance in host is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052014 name: catabolism by symbiont of host protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host protein" EXACT [] is_a: GO:0052013 ! catabolism by symbiont of host macromolecule is_a: GO:0052228 ! metabolism by symbiont of host protein is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052015 name: catabolism by symbiont of host carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host carbohydrate" EXACT [] is_a: GO:0052013 ! catabolism by symbiont of host macromolecule is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052016 name: catabolism by symbiont of host glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host glucan" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052176 ! metabolism by symbiont of host glucan is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052017 name: catabolism by symbiont of host xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of host xylan" EXACT [] is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate is_a: GO:0052177 ! metabolism by symbiont of host xylan is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052018 name: modulation by symbiont of RNA levels in host namespace: biological_process def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host RNA levels" EXACT [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction [Term] id: GO:0052019 name: modulation by symbiont of host hormone or growth regulator levels namespace: biological_process alt_id: GO:0052186 def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0052020 name: modification by symbiont of host cell wall namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "metabolism of host cell wall by organism" EXACT [] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052021 name: modulation by symbiont of ethylene levels in host namespace: biological_process alt_id: GO:0052449 def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of ethylene levels in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0052022 name: modulation by symbiont of jasmonic acid levels in host namespace: biological_process alt_id: GO:0052456 def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0052023 name: modulation by symbiont of salicylic acid levels in host namespace: biological_process alt_id: GO:0052469 def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0052024 name: positive regulation by symbiont of hormone or growth regulator levels in host namespace: biological_process alt_id: GO:0052513 def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW [] synonym: "positive modulation of hormone or growth regulator levels in host" EXACT [] synonym: "positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD [] synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW [] synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT [] synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT [] synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT [] is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0052025 name: modification by symbiont of host cell membrane namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a host cellular membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification by symbiont of host cell membrane" NARROW [GOC:bf, GOC:jl] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052332 ! modification by organism of membrane in other organism involved in symbiotic interaction [Term] id: GO:0052026 name: modulation by symbiont of host transcription namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction [Term] id: GO:0052027 name: modulation by symbiont of host signal transduction pathway namespace: biological_process alt_id: GO:0052250 def: "Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host signal transduction" RELATED [] synonym: "modulation of host signal transduction by symbiont" EXACT [] synonym: "modulation of signal transduction in other organism involved in symbiotic interaction" BROAD [] synonym: "regulation by symbiont of host signal transduction pathway" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0044501 ! modulation of signal transduction in other organism [Term] id: GO:0052028 name: induction by symbiont of host signal transduction pathway namespace: biological_process alt_id: GO:0044502 alt_id: GO:0052526 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host signal transduction pathway" NARROW [] synonym: "positive regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "positive regulation of signal transduction in other organism" BROAD [] synonym: "stimulation by symbiont of host signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "upregulation by symbiont of host signal transduction pathway" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0052029 name: suppression by symbiont of host signal transduction pathway namespace: biological_process alt_id: GO:0052493 def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of host signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of host signal transduction pathway" NARROW [] synonym: "negative modulation by organism of host signal transduction pathway" EXACT [] synonym: "negative regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of host signal transduction pathway" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0052031 name: modulation by symbiont of host defense response namespace: biological_process alt_id: GO:0052255 def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "mitigation by symbiont of host defense response" EXACT [] synonym: "modulation by organism of defense response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052200 ! response to host defenses [Term] id: GO:0052032 name: modulation by symbiont of host inflammatory response namespace: biological_process alt_id: GO:0052256 def: "Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052033 name: obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response namespace: biological_process def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] comment: This term was obsoleted because it has been misused. synonym: "general elicitor-dependent activation of host innate immunity" EXACT [] synonym: "general elicitor-dependent induction of host innate immunity" EXACT [] synonym: "MAMP dependent activation of host innate immunity" EXACT [] synonym: "MAMP dependent induction of host innate immunity" EXACT [] synonym: "PAMP dependent activation of host innate immunity" EXACT [] synonym: "PAMP dependent induction of host innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity" EXACT [GOC:pg] synonym: "pattern-triggered immunity" RELATED [GOC:tb] synonym: "PTI" RELATED [GOC:tb] is_obsolete: true consider: GO:0002221 consider: GO:0002752 consider: GO:0052034 [Term] id: GO:0052034 name: suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response namespace: biological_process alt_id: GO:0052258 def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response" EXACT [] synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [] synonym: "suppression of general elicitor induced host innate immunity" EXACT [] synonym: "suppression of general elicitor-induced host innate immunity" EXACT [] synonym: "suppression of MAMP induced host innate immunity" EXACT [] synonym: "suppression of MAMP-induced host innate immunity" EXACT [] synonym: "suppression of PAMP induced host innate immunity" EXACT [] synonym: "suppression of PAMP-induced host innate immunity" EXACT [] synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] is_a: GO:0052157 ! modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response is_a: GO:0052170 ! suppression by symbiont of host innate immune response [Term] id: GO:0052035 name: positive regulation by symbiont of host inflammatory response namespace: biological_process alt_id: GO:0052259 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host inflammatory response" NARROW [] synonym: "positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] synonym: "stimulation by symbiont of host inflammatory response" NARROW [] synonym: "up regulation by symbiont of host inflammatory response" EXACT [] synonym: "up-regulation by symbiont of host inflammatory response" EXACT [] synonym: "upregulation by symbiont of host inflammatory response" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052032 ! modulation by symbiont of host inflammatory response [Term] id: GO:0052036 name: suppression by symbiont of host inflammatory response namespace: biological_process alt_id: GO:0052260 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host inflammatory response" EXACT [] synonym: "down-regulation by symbiont of host inflammatory response" EXACT [] synonym: "downregulation by symbiont of host inflammatory response" EXACT [] synonym: "inhibition by symbiont of host inflammatory response" NARROW [] synonym: "negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of host inflammatory response" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052032 ! modulation by symbiont of host inflammatory response [Term] id: GO:0052038 name: modulation by symbiont of host intracellular transport namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of host intracellular trafficking" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052230 ! modulation of intracellular transport in other organism involved in symbiotic interaction intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0046907 ! intracellular transport [Term] id: GO:0052039 name: modification by symbiont of host cytoskeleton namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052043 ! modification by symbiont of host cellular component is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction [Term] id: GO:0052040 name: modulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0052152 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "modulation of host PCD" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0012501 ! programmed cell death [Term] id: GO:0052041 name: negative regulation by symbiont of host programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host programmed cell death" EXACT [] synonym: "down-regulation by symbiont of host programmed cell death" EXACT [] synonym: "downregulation by symbiont of host programmed cell death" EXACT [] synonym: "inhibition by symbiont of host programmed cell death" NARROW [] synonym: "inhibition of host programmed cell death" EXACT [] synonym: "suppression by symbiont of host PCD" EXACT [] synonym: "suppression by symbiont of host programmed cell death" EXACT [] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0052040 ! modulation by symbiont of host programmed cell death intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: negatively_regulates GO:0012501 ! programmed cell death [Term] id: GO:0052042 name: positive regulation by symbiont of host programmed cell death namespace: biological_process alt_id: GO:0012504 alt_id: GO:0052044 alt_id: GO:0052045 alt_id: GO:0052153 alt_id: GO:0052397 alt_id: GO:0052400 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "activation by organism of host programmed cell death" EXACT [] synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW [] synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] synonym: "activation by symbiont of host programmed cell death" NARROW [] synonym: "enhancement of host programmed cell death" EXACT [] synonym: "enhancement of host programmed cell death by organism" EXACT [] synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "induction by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] synonym: "induction by symbiont of host programmed cell death" EXACT [] synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED [] synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW [] synonym: "stimulation by symbiont of host programmed cell death" NARROW [] synonym: "upregulation by symbiont of host programmed cell death" EXACT [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: positively_regulates GO:0012501 ! programmed cell death relationship: part_of GO:0001907 ! killing by symbiont of host cells [Term] id: GO:0052043 name: modification by symbiont of host cellular component namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052111 ! modification by symbiont of host structure is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052046 name: obsolete modification by symbiont of host morphology or physiology via secreted substance namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification of host morphology or physiology via effector molecule" NARROW [] synonym: "modification of host morphology or physiology via ellicitor" NARROW [] is_obsolete: true [Term] id: GO:0052047 name: symbiotic process mediated by secreted substance namespace: biological_process def: "An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph] synonym: "interaction with other organism via secreted substance involved in symbiotic interaction" RELATED [] is_a: GO:0044403 ! symbiotic process [Term] id: GO:0052048 name: obsolete interaction with host via secreted substance namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph] synonym: "interaction with host via secreted substance involved in symbiotic interaction" RELATED [] is_obsolete: true [Term] id: GO:0052049 name: obsolete interaction with host via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052050 name: obsolete interaction with host via substance secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052051 name: obsolete interaction with host via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052052 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052053 name: negative regulation by symbiont of host catalytic activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host enzyme activity" EXACT [] synonym: "down-regulation by symbiont of host enzyme activity" EXACT [] synonym: "downregulation by symbiont of host enzyme activity" EXACT [] synonym: "inhibition by symbiont of host enzyme activity" NARROW [] synonym: "inhibition of host enzyme activity" EXACT [] synonym: "negative regulation by symbiont of host enzyme activity" EXACT [] is_a: GO:0052056 ! negative regulation by symbiont of host molecular function is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0052054 name: negative regulation by symbiont of host peptidase activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by symbiont of host protease activity" NARROW [] synonym: "down-regulation by symbiont of host protease activity" NARROW [] synonym: "downregulation by symbiont of host protease activity" NARROW [] synonym: "inhibition by symbiont of host protease activity" NARROW [] synonym: "inhibition of host protease activity" NARROW [] synonym: "negative regulation by symbiont of host protease activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity is_a: GO:0052149 ! modulation by symbiont of host peptidase activity is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0052055 name: modulation by symbiont of host molecular function namespace: biological_process def: "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification by symbiont of host molecular function" EXACT [] synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0003674 ! molecular_function [Term] id: GO:0052056 name: negative regulation by symbiont of host molecular function namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by symbiont of host protein function" EXACT [] synonym: "down-regulation by symbiont of host protein function" EXACT [] synonym: "downregulation by symbiont of host protein function" EXACT [] synonym: "inhibition by symbiont of host protein function" NARROW [] synonym: "inhibition of host protein function" EXACT [] synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0003674 ! molecular_function [Term] id: GO:0052057 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052058 name: obsolete modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052062 name: induction by symbiont of host phytoalexin production namespace: biological_process alt_id: GO:0052262 def: "The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of host phytoalexin production" EXACT [] synonym: "induction by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052063 name: induction by symbiont of defense-related host nitric oxide production namespace: biological_process alt_id: GO:0052263 alt_id: GO:0052345 alt_id: GO:0052347 def: "The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of defense-related host nitric oxide production" EXACT [] synonym: "activation by organism of defense-related host NO production" EXACT [] synonym: "activation by symbiont of defense-related host nitric oxide production" RELATED [] synonym: "induction by organism of defense-related host NO production" EXACT [] synonym: "induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" RELATED [] synonym: "positive regulation by organism of defense-related host NO production" RELATED [] synonym: "positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host nitric oxide production" RELATED [] synonym: "stimulation by symbiont of defense-related host nitric oxide production" RELATED [] synonym: "up regulation by symbiont of defense-related host nitric oxide production" RELATED [] synonym: "up-regulation by symbiont of defense-related host nitric oxide production" RELATED [] synonym: "upregulation by symbiont of defense-related host nitric oxide production" RELATED [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052064 name: induction by symbiont of defense-related host reactive oxygen species production namespace: biological_process alt_id: GO:0052264 alt_id: GO:0052348 alt_id: GO:0052369 def: "The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of defense-related host metabolic burst" EXACT [] synonym: "activation by symbiont of defense-related host oxidative burst" EXACT [] synonym: "activation by symbiont of defense-related host reactive oxidative species production" EXACT [] synonym: "activation by symbiont of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "activation by symbiont of defense-related host reactive oxygen species production" EXACT [] synonym: "activation by symbiont of defense-related host respiratory burst" EXACT [] synonym: "activation by symbiont of defense-related host ROI production" EXACT [] synonym: "activation by symbiont of defense-related host ROS production" EXACT [] synonym: "induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by symbiont of defense-related host active oxygen species production" EXACT [] synonym: "induction by symbiont of defense-related host AOS production" EXACT [] synonym: "induction by symbiont of defense-related host metabolic burst" EXACT [] synonym: "induction by symbiont of defense-related host oxidative burst" EXACT [] synonym: "induction by symbiont of defense-related host reactive oxidative species production" EXACT [] synonym: "induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" RELATED [] synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" RELATED [] is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052066 name: entry of symbiont into host cell by promotion of host phagocytosis namespace: biological_process alt_id: GO:0052370 def: "The invasion by a symbiont of a host organism cell by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction" RELATED [] synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT [] synonym: "penetration of organism into host cell by promotion of host phagocytosis" EXACT [GOC:vw] synonym: "penetration of symbiont into host cell by promotion of host phagocytosis" EXACT [GOC:vw] is_a: GO:0030260 ! entry into host cell is_a: GO:0052191 ! positive regulation by symbiont of host phagocytosis [Term] id: GO:0052067 name: negative regulation by symbiont of entry into host cell via phagocytosis namespace: biological_process def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "downregulation by symbiont of entry into host cell via phagocytosis" EXACT [] synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW [] synonym: "negative regulation by organism of entry into host cell via host phagocytosis" EXACT [] is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0052380 ! modulation by symbiont of entry into host via phagocytosis is_a: GO:0052483 ! negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052068 name: suppression by symbiont of host jasmonic acid-mediated defense response namespace: biological_process alt_id: GO:0052069 alt_id: GO:0052266 alt_id: GO:0052267 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" BROAD [] synonym: "negative regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "suppression by organism of host JA-mediated defense response" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052562 ! suppression by symbiont of host immune response [Term] id: GO:0052072 name: induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052270 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway [Term] id: GO:0052073 name: induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052271 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0052075 ! positive regulation by symbiont of host jasmonic acid-mediated defense response is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response [Term] id: GO:0052074 name: positive regulation by symbiont of host salicylic acid-mediated defense response namespace: biological_process alt_id: GO:0052272 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "induction by organism of host SA-mediated defense response" NARROW [] synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of host SA-mediated defense response" EXACT [] synonym: "positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response is_a: GO:1901672 ! positive regulation of systemic acquired resistance is_a: GO:2001040 ! positive regulation of cellular response to drug relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052075 name: positive regulation by symbiont of host jasmonic acid-mediated defense response namespace: biological_process alt_id: GO:0052273 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "induction by organism of host JA-mediated defense response" NARROW [] synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of host JA-mediated defense response" EXACT [] synonym: "positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052076 name: induction by symbiont of host ethylene-mediated defense response namespace: biological_process alt_id: GO:0052071 alt_id: GO:0052269 alt_id: GO:0052274 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] synonym: "positive regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW [] synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT [] synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response [Term] id: GO:0052078 name: suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052275 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway is_a: GO:0075132 ! suppression by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052079 name: induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052276 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway is_a: GO:0075131 ! induction by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052080 name: modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052277 def: "Any process in which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT [] synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0052081 name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway namespace: biological_process alt_id: GO:0052445 def: "Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052083 name: suppression by symbiont of host cell-mediated immune response namespace: biological_process alt_id: GO:0052278 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT [] synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW [] synonym: "negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by organism of host cell-based immune response" EXACT [] is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response is_a: GO:0052562 ! suppression by symbiont of host immune response [Term] id: GO:0052084 name: modulation by symbiont of host ethylene-mediated defense response namespace: biological_process alt_id: GO:0052077 alt_id: GO:0052279 alt_id: GO:0052441 def: "Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052085 name: suppression by symbiont of host T-cell mediated immune response namespace: biological_process alt_id: GO:0052280 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT [] synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW [] synonym: "negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of host T-cell mediated immune response" EXACT [] is_a: GO:0052083 ! suppression by symbiont of host cell-mediated immune response is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response [Term] id: GO:0052086 name: suppression by symbiont of host B-cell mediated immune response namespace: biological_process alt_id: GO:0052281 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT [] synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW [] synonym: "negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052083 ! suppression by symbiont of host cell-mediated immune response is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response [Term] id: GO:0052088 name: modulation by symbiont of host jasmonic acid-mediated defense response namespace: biological_process alt_id: GO:0052082 alt_id: GO:0052283 alt_id: GO:0052443 def: "Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of host JA-mediated defense response" EXACT [] synonym: "modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" BROAD [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052089 name: modulation by symbiont of host salicylic acid-mediated defense response namespace: biological_process alt_id: GO:0052284 def: "Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of host SA-mediated defense response" EXACT [] synonym: "modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052031 ! modulation by symbiont of host defense response is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway relationship: regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] id: GO:0052091 name: modulation by symbiont of nutrient release from host namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction relationship: part_of GO:0044002 ! acquisition of nutrients from host [Term] id: GO:0052092 name: positive regulation by symbiont of nutrient release from host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of nutrient release from host" NARROW [] synonym: "promotion of nutrient release from host" EXACT [] synonym: "stimulation by symbiont of nutrient release from host" NARROW [] synonym: "up regulation by symbiont of nutrient release from host" EXACT [] synonym: "up-regulation by symbiont of nutrient release from host" EXACT [] synonym: "upregulation by symbiont of nutrient release from host" EXACT [] is_a: GO:0052091 ! modulation by symbiont of nutrient release from host is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052093 name: formation of specialized structure for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT [] synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction relationship: part_of GO:0044002 ! acquisition of nutrients from host [Term] id: GO:0052094 name: formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT [] synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT [] is_a: GO:0044118 ! development of symbiont in host cell is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0052095 name: formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044111 ! development involved in symbiotic interaction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0052096 name: formation by symbiont of syncytium involving giant cell for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of a syncytium, a nematode-induced multi-nucleate and physiologically active aggregation of fused root cells which exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT [] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0052097 name: obsolete interspecies quorum sensing namespace: biological_process def: "OBSOLETE. The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was an unnecessary grouping term. is_obsolete: true [Term] id: GO:0052098 name: formation by host of specialized structure for nutrient acquisition from symbiont namespace: biological_process def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont [Term] id: GO:0052100 name: obsolete intraspecies quorum sensing namespace: biological_process def: "OBSOLETE. The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was an unnecessary grouping term. is_obsolete: true [Term] id: GO:0052102 name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway namespace: biological_process alt_id: GO:0052287 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] synonym: "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT [] synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] is_a: GO:0044416 ! induction by symbiont of host defense response [Term] id: GO:0052103 name: induction by symbiont of host induced systemic resistance namespace: biological_process alt_id: GO:0052288 alt_id: GO:0052532 alt_id: GO:0052533 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of induced systemic resistance in host" EXACT [] synonym: "activation by organism of ISR in host" EXACT [] synonym: "activation by symbiont of induced systemic resistance in host" NARROW [] synonym: "induction by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by organism of ISR in host" EXACT [] synonym: "induction by symbiont of induced systemic resistance in host" EXACT [] synonym: "positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of host induced systemic resistance" RELATED [] synonym: "positive regulation by symbiont of induced systemic resistance in host" RELATED [] synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW [] synonym: "up regulation by symbiont of induced systemic resistance in host" RELATED [] synonym: "up-regulation by symbiont of induced systemic resistance in host" RELATED [] synonym: "upregulation by symbiont of induced systemic resistance in host" RELATED [] is_a: GO:0052159 ! modulation by symbiont of host induced systemic resistance is_a: GO:0052390 ! induction by symbiont of host innate immune response [Term] id: GO:0052104 name: induction by symbiont of host systemic acquired resistance namespace: biological_process alt_id: GO:0052289 alt_id: GO:0052535 alt_id: GO:0052537 def: "Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of SAR in host" EXACT [] synonym: "activation by organism of systemic acquired resistance in host" EXACT [] synonym: "induction by organism of SAR in host" EXACT [] synonym: "induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by symbiont of systemic acquired resistance in host" EXACT [] synonym: "positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of host systemic acquired resistance" RELATED [] synonym: "positive regulation by symbiont of systemic acquired resistance in host" RELATED [] synonym: "stimulation by symbiont of systemic acquired resistance in host" RELATED [] synonym: "up regulation by symbiont of systemic acquired resistance in host" RELATED [] synonym: "up-regulation by symbiont of systemic acquired resistance in host" RELATED [] synonym: "upregulation by symbiont of systemic acquired resistance in host" RELATED [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052160 ! modulation by symbiont of host systemic acquired resistance is_a: GO:0052390 ! induction by symbiont of host innate immune response [Term] id: GO:0052105 name: induction by symbiont of defense-related host cell wall thickening namespace: biological_process alt_id: GO:0052290 alt_id: GO:0052538 alt_id: GO:0052539 def: "The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of defense-related host cell wall thickening" EXACT [] synonym: "activation by organism of host defensive cell wall thickening" EXACT [] synonym: "activation by symbiont of defense-related host cell wall thickening" EXACT [] synonym: "induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by organism of host defensive cell wall thickening" EXACT [] synonym: "positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of host defensive cell wall thickening" RELATED [] synonym: "positive regulation by symbiont of defense-related host cell wall thickening" RELATED [] synonym: "stimulation by symbiont of defense-related host cell wall thickening" RELATED [] synonym: "up regulation by symbiont of defense-related host cell wall thickening" RELATED [] synonym: "up-regulation by symbiont of defense-related host cell wall thickening" RELATED [] synonym: "upregulation by symbiont of defense-related host cell wall thickening" RELATED [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening [Term] id: GO:0052106 name: obsolete quorum sensing involved in interaction with host namespace: biological_process def: "OBSOLETE. The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this term was not clearly defined and usage was inconsistent. synonym: "quorum sensing during interaction with host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0052108 name: obsolete growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont during interaction with host ; GO:0044116' and 'development of symbiont during interaction with host ; GO:0044115'. synonym: "growth or development of organism during interaction with host" EXACT [] synonym: "growth or development of organism in response to host" EXACT [] synonym: "growth or development of symbiont during interaction with host" EXACT [] is_obsolete: true consider: GO:0044115 consider: GO:0044117 [Term] id: GO:0052109 name: induction by symbiont of defense-related host cell wall callose deposition namespace: biological_process alt_id: GO:0052107 alt_id: GO:0052291 alt_id: GO:0052292 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of defense-related host callose deposition" RELATED [] synonym: "positive regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" RELATED [] synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" RELATED [] is_a: GO:0052105 ! induction by symbiont of defense-related host cell wall thickening is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition [Term] id: GO:0052110 name: occlusion by symbiont of host vascular system namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] is_a: GO:0052111 ! modification by symbiont of host structure is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052111 name: modification by symbiont of host structure namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044003 ! modification by symbiont of host morphology or physiology is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052112 name: occlusion by symbiont of host xylem namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052110 ! occlusion by symbiont of host vascular system is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction [Term] id: GO:0052113 name: obsolete adaptation to host osmotic environment namespace: biological_process def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. synonym: "adaptation to host osmotic environment" EXACT [] synonym: "osmotic tolerance to host environment" EXACT [] is_obsolete: true [Term] id: GO:0052114 name: obsolete adaptation to host pH environment namespace: biological_process def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. synonym: "adaptation to host pH environment" EXACT [] synonym: "pH tolerance to host environment" EXACT [] is_obsolete: true [Term] id: GO:0052115 name: energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "energy taxis in response to host environment" EXACT [] is_a: GO:0052126 ! movement in host environment is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052116 name: chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "chemotaxis in response to host environment" EXACT [] is_a: GO:0052126 ! movement in host environment is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052117 name: aerotaxis in host environment namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "aerotaxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052118 name: positive energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive energy taxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052119 name: negative energy taxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative energy taxis in response to host environment" EXACT [] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052120 name: positive aerotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive aerotaxis in response to host environment" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052121 name: positive chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive chemotaxis in response to host environment" EXACT [] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052122 name: negative aerotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative aerotaxis in response to host environment" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052123 name: negative chemotaxis in host environment namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative chemotaxis in response to host environment" EXACT [] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052124 name: energy taxis within host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044000 ! movement in host is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052125 name: energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052115 ! energy taxis in host environment is_a: GO:0052127 ! movement on or near host is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052126 name: movement in host environment namespace: biological_process def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "movement in response to host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052127 name: movement on or near host namespace: biological_process def: "The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052126 ! movement in host environment is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction [Term] id: GO:0052128 name: positive energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052129 name: negative energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] is_a: GO:0009453 ! energy taxis [Term] id: GO:0052130 name: negative aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] is_a: GO:0009454 ! aerotaxis is_a: GO:0050919 ! negative chemotaxis is_a: GO:0052129 ! negative energy taxis [Term] id: GO:0052131 name: positive aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] is_a: GO:0009454 ! aerotaxis is_a: GO:0050918 ! positive chemotaxis is_a: GO:0052128 ! positive energy taxis [Term] id: GO:0052132 name: positive aerotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052120 ! positive aerotaxis in host environment is_a: GO:0052138 ! aerotaxis on or near host is_a: GO:0052141 ! positive chemotaxis on or near host is_a: GO:0052146 ! positive energy taxis on or near host is_a: GO:0052232 ! positive aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052133 name: positive aerotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive aerotaxis within host" EXACT [] is_a: GO:0052120 ! positive aerotaxis in host environment is_a: GO:0052137 ! aerotaxis in host is_a: GO:0052140 ! positive chemotaxis in host is_a: GO:0052147 ! positive energy taxis in host is_a: GO:0052233 ! positive aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052134 name: negative aerotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052122 ! negative aerotaxis in host environment is_a: GO:0052136 ! negative chemotaxis on or near host is_a: GO:0052138 ! aerotaxis on or near host is_a: GO:0052145 ! negative energy taxis on or near host is_a: GO:0052234 ! negative aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052135 name: negative aerotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative aerotaxis within host" EXACT [] is_a: GO:0052122 ! negative aerotaxis in host environment is_a: GO:0052137 ! aerotaxis in host is_a: GO:0052139 ! negative chemotaxis in host is_a: GO:0052144 ! negative energy taxis in host is_a: GO:0052235 ! negative aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052136 name: negative chemotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052137 name: aerotaxis in host namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "aerotaxis within host" EXACT [] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052138 name: aerotaxis on or near host namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052117 ! aerotaxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052139 name: negative chemotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative chemotaxis within host" EXACT [] is_a: GO:0052123 ! negative chemotaxis in host environment is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052140 name: positive chemotaxis in host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive chemotaxis within host" EXACT [] is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052142 ! chemotaxis within host is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052141 name: positive chemotaxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052121 ! positive chemotaxis in host environment is_a: GO:0052143 ! chemotaxis on or near host involved in symbiotic interaction is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052142 name: chemotaxis within host namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044000 ! movement in host is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052143 name: chemotaxis on or near host involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "chemotaxis on or near host during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052116 ! chemotaxis in host environment is_a: GO:0052127 ! movement on or near host is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052144 name: negative energy taxis in host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative energy taxis within host" EXACT [] is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052145 name: negative energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052119 ! negative energy taxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052146 name: positive energy taxis on or near host namespace: biological_process def: "The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052125 ! energy taxis on or near host is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052147 name: positive energy taxis in host namespace: biological_process def: "The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive energy taxis within host" EXACT [] is_a: GO:0052118 ! positive energy taxis in host environment is_a: GO:0052124 ! energy taxis within host is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052148 name: modulation by symbiont of host catalytic activity namespace: biological_process def: "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb] synonym: "modulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation by symbiont of host catalytic activity" EXACT [] synonym: "regulation of catalytic activity of host by symbiont" EXACT [] synonym: "regulation of host catalytic activity by symbiont" EXACT [] is_a: GO:0052055 ! modulation by symbiont of host molecular function is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: regulates GO:0003824 ! catalytic activity [Term] id: GO:0052149 name: modulation by symbiont of host peptidase activity namespace: biological_process def: "The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by symbiont of host protease activity" NARROW [GOC:bf] is_a: GO:0052148 ! modulation by symbiont of host catalytic activity is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: regulates GO:0008233 ! peptidase activity [Term] id: GO:0052150 name: modulation by symbiont of host apoptotic process namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. synonym: "modulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "modulation by symbiont of host apoptosis" NARROW [] is_a: GO:0052040 ! modulation by symbiont of host programmed cell death is_a: GO:0052433 ! modulation by organism of apoptotic process in other organism involved in symbiotic interaction intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0006915 ! apoptotic process [Term] id: GO:0052151 name: positive regulation by symbiont of host apoptotic process namespace: biological_process alt_id: GO:0033669 alt_id: GO:0052030 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. synonym: "activation by organism of host apoptosis" EXACT [] synonym: "activation by organism of host apoptotic programmed cell death" EXACT [] synonym: "activation by symbiont of host apoptosis" NARROW [] synonym: "induction by organism of host apoptotic programmed cell death" EXACT [] synonym: "induction by symbiont of host apoptosis" EXACT [] synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "positive regulation by symbiont of host apoptosis" NARROW [] synonym: "stimulation by symbiont of host apoptosis" NARROW [] synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up regulation by symbiont of host apoptosis" EXACT [] synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "up-regulation by symbiont of host apoptosis" EXACT [] synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT [] synonym: "upregulation by symbiont of host apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052150 ! modulation by symbiont of host apoptotic process intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0052154 name: modulation by symbiont of host B-cell mediated immune response namespace: biological_process alt_id: GO:0052293 def: "Any process in which a symbiont modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "regulation by organism of host B-cell mediated immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052155 name: modulation by symbiont of host cell-mediated immune response namespace: biological_process alt_id: GO:0052294 def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of host cell-based immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052156 name: modulation by symbiont of host T-cell mediated immune response namespace: biological_process alt_id: GO:0052295 def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response [Term] id: GO:0052157 name: modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response namespace: biological_process alt_id: GO:0052296 def: "Any process that involves recognition of a microbe-associated molecular pattern, and by which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] synonym: "modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [GOC:pg] synonym: "modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] is_a: GO:0052167 ! modulation by symbiont of host innate immune response [Term] id: GO:0052158 name: modulation by symbiont of host resistance gene-dependent defense response namespace: biological_process alt_id: GO:0052297 def: "Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense response in host by specific elicitors" EXACT [] synonym: "modulation by organism of host gene-for-gene resistance" EXACT [] synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] synonym: "modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0075136 ! response to host [Term] id: GO:0052159 name: modulation by symbiont of host induced systemic resistance namespace: biological_process alt_id: GO:0052298 def: "Any process in which a symbiont modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of induced systemic resistance in host" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052160 name: modulation by symbiont of host systemic acquired resistance namespace: biological_process alt_id: GO:0052299 def: "Any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052161 name: modulation by symbiont of defense-related host cell wall thickening namespace: biological_process alt_id: GO:0052300 def: "Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of host defensive cell wall thickening" RELATED [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052162 name: modulation by symbiont of defense-related host calcium ion flux namespace: biological_process alt_id: GO:0052301 def: "Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052163 name: modulation by symbiont of defense-related host nitric oxide production namespace: biological_process alt_id: GO:0052060 alt_id: GO:0052302 alt_id: GO:0052376 def: "Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of host nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of host NO" EXACT [] synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of host-produced NO" EXACT [] synonym: "evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction" BROAD [] synonym: "evasion or tolerance by symbiont of host-produced nitric oxide" EXACT [] synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT [] synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT [] synonym: "modulation by organism of defense-related host NO production" EXACT [] synonym: "modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of defense-related host nitric oxide production" RELATED [] is_a: GO:0052167 ! modulation by symbiont of host innate immune response is_a: GO:0052565 ! response to defense-related host nitric oxide production [Term] id: GO:0052164 name: modulation by symbiont of defense-related host reactive oxygen species production namespace: biological_process alt_id: GO:0052059 alt_id: GO:0052303 alt_id: GO:0052385 alt_id: GO:0052550 alt_id: GO:0052567 def: "Any process in which a symbiont modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion by symbiont of cellular damage caused by host oxidative burst" NARROW [] synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT [] synonym: "evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD [] synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT [] synonym: "evasion or tolerance by symbiont of host-produced reactive oxygen species" EXACT [] synonym: "evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD [] synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT [] synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT [] synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT [] synonym: "evasion or tolerance of host-produced active oxygen species" EXACT [] synonym: "evasion or tolerance of host-produced AOS" EXACT [] synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT [] synonym: "evasion or tolerance of host-produced ROIs" EXACT [] synonym: "evasion or tolerance of host-produced ROS" EXACT [] synonym: "evasion or tolerance of reactive oxygen species produced by host" EXACT [] synonym: "modulation by organism of defense-related host active oxygen species production" EXACT [] synonym: "modulation by organism of defense-related host AOS production" EXACT [] synonym: "modulation by organism of defense-related host metabolic burst" EXACT [] synonym: "modulation by organism of defense-related host oxidative burst" EXACT [] synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT [] synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] synonym: "modulation by organism of defense-related host respiratory burst" EXACT [] synonym: "modulation by organism of defense-related host ROI production" EXACT [] synonym: "modulation by organism of defense-related host ROS production" EXACT [] synonym: "modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] synonym: "response to defense-related host reactive oxygen species production" RELATED [] synonym: "response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052167 ! modulation by symbiont of host innate immune response [Term] id: GO:0052165 name: modulation by symbiont of host phytoalexin production namespace: biological_process alt_id: GO:0052061 alt_id: GO:0052304 alt_id: GO:0052378 alt_id: GO:0052549 alt_id: GO:0052566 def: "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion or tolerance by organism of host phytoalexins" EXACT [] synonym: "evasion or tolerance by organism of host-produced phytoalexins" EXACT [] synonym: "evasion or tolerance by organism of phytoalexins produced by other organism involved in symbiotic interaction" BROAD [] synonym: "evasion or tolerance by symbiont of host-produced phytoalexins" EXACT [] synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [] synonym: "host phytoalexin detoxification" NARROW [] synonym: "modulation by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD [] synonym: "phytoalexin detoxification" NARROW [] synonym: "response to host phytoalexin production" BROAD [] synonym: "response to phytoalexin production by other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052167 ! modulation by symbiont of host innate immune response [Term] id: GO:0052167 name: modulation by symbiont of host innate immune response namespace: biological_process alt_id: GO:0052306 def: "Any process in which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of innate immune response in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of host innate immunity" EXACT [GOC:pg] synonym: "modulation of host innate immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052168 name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway namespace: biological_process alt_id: GO:0052307 def: "Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of defense-related host CDPK pathway" EXACT [] is_a: GO:0052031 ! modulation by symbiont of host defense response [Term] id: GO:0052169 name: obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response namespace: biological_process def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] comment: This term was obsoleted because it has been misused. synonym: "pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity" EXACT [GOC:pg] is_obsolete: true consider: GO:0002221 consider: GO:0002752 consider: GO:0052034 [Term] id: GO:0052170 name: suppression by symbiont of host innate immune response namespace: biological_process alt_id: GO:0052309 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host innate immunity" EXACT [] synonym: "down-regulation by symbiont of host innate immunity" EXACT [] synonym: "downregulation by symbiont of host innate immunity" EXACT [] synonym: "inhibition by symbiont of host innate immunity" NARROW [] synonym: "negative regulation by symbiont of host innate immune response" EXACT [] synonym: "negative regulation by symbiont of host innate immunity" EXACT [GOC:pg] synonym: "negative regulation of host innate immune response" EXACT [] synonym: "negative regulation of innate immune response in other organism" BROAD [] is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052167 ! modulation by symbiont of host innate immune response is_a: GO:0052562 ! suppression by symbiont of host immune response [Term] id: GO:0052171 name: obsolete growth or development during symbiotic interaction namespace: biological_process def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth during symbiotic interaction ; GO:0044110'. synonym: "growth or development during symbiotic interaction" EXACT [] is_obsolete: true consider: GO:0044110 consider: GO:0044111 [Term] id: GO:0052172 name: metabolism by symbiont of host cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction [Term] id: GO:0052173 name: response to defenses of other organism namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism." [GOC:mtg_pamgo_17jul06] comment: Updated term label and definition, see https://github.com/geneontology/go-ontology/issues/17930. synonym: "response to defenses of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "response to defenses of other organism involved in symbiotic interaction" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms is_a: GO:0051707 ! response to other organism [Term] id: GO:0052174 name: metabolism by symbiont of host macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052002 ! metabolism by symbiont of substance in host is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052175 name: metabolism by symbiont of host carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052176 name: metabolism by symbiont of host glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052177 name: metabolism by symbiont of host xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052178 name: metabolism by symbiont of host cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction [Term] id: GO:0052179 name: metabolism by symbiont of host cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction [Term] id: GO:0052180 name: negative regulation of peptidase activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0035940 ! negative regulation of peptidase activity in other organism is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052181 name: obsolete modulation by host of symbiont defense response namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. is_obsolete: true [Term] id: GO:0052182 name: obsolete modification by host of symbiont morphology or physiology via secreted substance namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true [Term] id: GO:0052183 name: modification by host of symbiont structure namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052184 name: obsolete modulation by organism of symbiont hormone or growth regulator levels namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont hormone or growth regulator levels" EXACT [] is_obsolete: true [Term] id: GO:0052185 name: modification of structure of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification of structure of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052187 name: modification by host of symbiont cellular component namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052183 ! modification by host of symbiont structure is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052188 name: modification of cellular component in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052189 name: modulation by symbiont of defense-related host cell wall callose deposition namespace: biological_process alt_id: GO:0052090 alt_id: GO:0052285 alt_id: GO:0052310 def: "Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] synonym: "modulation by symbiont of defense-related host callose deposition" BROAD [] is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening [Term] id: GO:0052190 name: modulation by symbiont of host phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: regulates GO:0006909 ! phagocytosis [Term] id: GO:0052191 name: positive regulation by symbiont of host phagocytosis namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host phagocytosis" NARROW [] synonym: "stimulation by symbiont of host phagocytosis" NARROW [] synonym: "up regulation by symbiont of host phagocytosis" EXACT [] synonym: "up-regulation by symbiont of host phagocytosis" EXACT [] synonym: "upregulation by symbiont of host phagocytosis" EXACT [] is_a: GO:0052190 ! modulation by symbiont of host phagocytosis is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction intersection_of: GO:0044003 ! modification by symbiont of host morphology or physiology intersection_of: positively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0052192 name: movement in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "locomotion in environment of other organism during symbiotic interaction" RELATED [] synonym: "movement in environment of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0040011 ! locomotion is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0052193 name: obsolete movement in symbiont environment namespace: biological_process def: "OBSOLETE. The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_obsolete: true [Term] id: GO:0052194 name: obsolete movement on or near symbiont namespace: biological_process def: "OBSOLETE. The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_obsolete: true [Term] id: GO:0052195 name: movement on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "movement on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052196 name: obsolete negative regulation by host of symbiont defense response namespace: biological_process def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. See https://github.com/geneontology/go-ontology/issues/14862 synonym: "down regulation by host of symbiont defense response" EXACT [] synonym: "down-regulation by host of symbiont defense response" EXACT [] synonym: "downregulation by host of symbiont defense response" EXACT [] synonym: "inhibition by host of symbiont defense response" NARROW [] is_obsolete: true [Term] id: GO:0052197 name: obsolete positive regulation by host of symbiont defense response namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. synonym: "activation by host of symbiont defense response" NARROW [] synonym: "stimulation by host of symbiont defense response" NARROW [] synonym: "up regulation by host of symbiont defense response" EXACT [] synonym: "up-regulation by host of symbiont defense response" EXACT [] synonym: "upregulation by host of symbiont defense response" EXACT [] is_obsolete: true [Term] id: GO:0052198 name: modulation of peptidase activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation of protease activity in other organism involved in symbiotic interaction" NARROW [GOC:bf] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction [Term] id: GO:0052199 name: negative regulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] synonym: "inhibition of enzyme activity in other organism" EXACT [] synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction intersection_of: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction intersection_of: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0052200 name: response to host defenses namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052173 ! response to defenses of other organism is_a: GO:0075136 ! response to host [Term] id: GO:0052201 name: response to symbiont defenses namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0009608 ! response to symbiont is_a: GO:0052173 ! response to defenses of other organism [Term] id: GO:0052202 name: negative regulation by symbiont of defense-related host cell wall callose deposition namespace: biological_process alt_id: GO:0052087 alt_id: GO:0052282 alt_id: GO:0052311 def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW [] synonym: "negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of defense-related host callose deposition" BROAD [] is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition [Term] id: GO:0052203 name: modulation of catalytic activity in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052204 name: negative regulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT [] synonym: "inhibition of protein function in other organism" EXACT [] synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW [] synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] is_a: GO:0044362 ! negative regulation of molecular function in other organism is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052205 name: modulation of molecular function in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT [] synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044359 ! modulation of molecular function in other organism is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052206 name: obsolete modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052207 name: obsolete modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052208 name: obsolete modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052209 name: obsolete interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052210 name: obsolete interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052211 name: obsolete interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0052212 name: obsolete modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification of host morphology or physiology via effector molecule" NARROW [] synonym: "modification of host morphology or physiology via ellicitor" NARROW [] synonym: "modification of morphology or physiology of other organism via secreted substance during symbiotic interaction" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0052213 name: obsolete interaction with symbiont via secreted substance namespace: biological_process def: "OBSOLETE. An interaction with a symbiont organism mediated by a substance secreted by a host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that this process was not clearly defined, and propably represented some immune response. . synonym: "interaction with symbiont via secreted substance during symbiotic interaction" RELATED [GOC:dph] synonym: "interaction with symbiont via secreted substance involved in symbiotic interaction" RELATED [] is_obsolete: true [Term] id: GO:0052214 name: metabolism of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044033 ! multi-organism metabolic process is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0052215 name: energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "energy taxis in response to environment of other organism" EXACT [] is_a: GO:0009453 ! energy taxis is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052216 name: chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0052192 ! movement in environment of other organism involved in symbiotic interaction [Term] id: GO:0052217 name: aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0009454 ! aerotaxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052218 name: positive energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive energy taxis in response to environment of other organism" EXACT [] is_a: GO:0052128 ! positive energy taxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052219 name: negative energy taxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative energy taxis in response to environment of other organism" EXACT [] is_a: GO:0052129 ! negative energy taxis is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052220 name: positive aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0052131 ! positive aerotaxis is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052221 name: positive chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0050918 ! positive chemotaxis is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052222 name: negative aerotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative aerotaxis in response to environment of other organism" EXACT [] is_a: GO:0052130 ! negative aerotaxis is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052223 name: negative chemotaxis in environment of other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative chemotaxis in response to environment of other organism" EXACT [] is_a: GO:0050919 ! negative chemotaxis is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052224 name: energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "energy taxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052225 name: energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction is_a: GO:0052215 ! energy taxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052226 name: biosynthesis of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "biosynthesis of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044034 ! multi-organism biosynthetic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052227 name: catabolism of substance in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "catabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044035 ! multi-organism catabolic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052228 name: metabolism by symbiont of host protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052174 ! metabolism by symbiont of host macromolecule is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052229 name: metabolism of macromolecule in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052230 name: modulation of intracellular transport in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of intracellular trafficking in other organism" EXACT [] synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052231 name: modulation of phagocytosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052232 name: positive aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052241 ! positive chemotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052246 ! positive energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052233 name: positive aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052220 ! positive aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction is_a: GO:0052240 ! positive chemotaxis in other organism involved in symbiotic interaction is_a: GO:0052247 ! positive energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052234 name: negative aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052236 ! negative chemotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052238 ! aerotaxis on or near other organism involved in symbiotic interaction is_a: GO:0052245 ! negative energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052235 name: negative aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052222 ! negative aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052237 ! aerotaxis in other organism involved in symbiotic interaction is_a: GO:0052239 ! negative chemotaxis in other organism involved in symbiotic interaction is_a: GO:0052244 ! negative energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052236 name: negative chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052237 name: aerotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "aerotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052238 name: aerotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052217 ! aerotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052239 name: negative chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative chemotaxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052223 ! negative chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052240 name: positive chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive chemotaxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052242 ! chemotaxis in other organism involved in symbiotic interaction [Term] id: GO:0052241 name: positive chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052221 ! positive chemotaxis in environment of other organism involved in symbiotic interaction is_a: GO:0052243 ! chemotaxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052242 name: chemotaxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "chemotaxis within other organism during symbiotic interaction" EXACT [] is_a: GO:0051814 ! movement in other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052243 name: chemotaxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052195 ! movement on or near other organism involved in symbiotic interaction is_a: GO:0052216 ! chemotaxis in environment of other organism involved in symbiotic interaction [Term] id: GO:0052244 name: negative energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "negative energy taxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052245 name: negative energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "negative energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052219 ! negative energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052246 name: positive energy taxis on or near other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052225 ! energy taxis on or near other organism involved in symbiotic interaction [Term] id: GO:0052247 name: positive energy taxis in other organism involved in symbiotic interaction namespace: biological_process def: "The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "positive energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive energy taxis within other organism during symbiotic interaction" RELATED [] is_a: GO:0052218 ! positive energy taxis in environment of other organism involved in symbiotic interaction is_a: GO:0052224 ! energy taxis in other organism involved in symbiotic interaction [Term] id: GO:0052248 name: modulation of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052459 def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "modulation of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044531 ! modulation of programmed cell death in other organism is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052249 name: modulation of RNA levels in other organism involved in symbiotic interaction namespace: biological_process def: "The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of RNA levels in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0052257 name: obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] comment: This term was obsoleted because it has been misused. synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT [] synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT [] synonym: "MAMP dependent induction of innate immunity of other organism" EXACT [] synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT [] synonym: "PAMP dependent induction of innate immunity of other organism" EXACT [] synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT [] synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction" EXACT [GOC:pg] is_obsolete: true consider: GO:0002221 consider: GO:0002752 consider: GO:0052034 [Term] id: GO:0052308 name: obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction namespace: biological_process def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] comment: This term was obsoleted because it has been misused. synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg] is_obsolete: true consider: GO:0002221 consider: GO:0002752 consider: GO:0052034 [Term] id: GO:0052312 name: modulation of transcription in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of transcription in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction is_a: GO:2001141 ! regulation of RNA biosynthetic process [Term] id: GO:0052313 name: modulation of nutrient release from other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation of nutrient release from other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction [Term] id: GO:0052314 name: phytoalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] subset: goslim_pir synonym: "phytoalexin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0052315 name: phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] synonym: "phytoalexin biosynthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052316 name: phytoalexin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] synonym: "phytoalexin catabolism" EXACT [] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052317 name: camalexin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai] synonym: "camalexin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046217 ! indole phytoalexin metabolic process [Term] id: GO:0052318 name: regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] synonym: "regulation of phytoalexin metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052314 ! phytoalexin metabolic process relationship: regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052319 name: regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] synonym: "regulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052315 ! phytoalexin biosynthetic process relationship: regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052320 name: positive regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06] synonym: "activation of phytoalexin metabolism" NARROW [] synonym: "positive regulation of phytoalexin metabolism" RELATED [] synonym: "stimulation of phytoalexin metabolism" NARROW [] synonym: "up regulation of phytoalexin metabolism" EXACT [] synonym: "up-regulation of phytoalexin metabolism" EXACT [] synonym: "upregulation of phytoalexin metabolism" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052314 ! phytoalexin metabolic process relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052321 name: negative regulation of phytoalexin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai] synonym: "down regulation of phytoalexin metabolism" EXACT [] synonym: "down-regulation of phytoalexin metabolism" EXACT [] synonym: "downregulation of phytoalexin metabolism" EXACT [] synonym: "inhibition of phytoalexin metabolism" NARROW [] synonym: "negative regulation of phytoalexin metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0052318 ! regulation of phytoalexin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052314 ! phytoalexin metabolic process relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0052322 name: positive regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06] synonym: "activation of phytoalexin biosynthesis" NARROW [] synonym: "positive regulation of phytoalexin biosynthesis" EXACT [] synonym: "stimulation of phytoalexin biosynthesis" NARROW [] synonym: "up regulation of phytoalexin biosynthesis" EXACT [] synonym: "up-regulation of phytoalexin biosynthesis" EXACT [] synonym: "upregulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052315 ! phytoalexin biosynthetic process relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052323 name: negative regulation of phytoalexin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] synonym: "down regulation of phytoalexin biosynthesis" EXACT [] synonym: "down-regulation of phytoalexin biosynthesis" EXACT [] synonym: "downregulation of phytoalexin biosynthesis" EXACT [] synonym: "inhibition of phytoalexin biosynthesis" NARROW [] synonym: "negative regulation of phytoalexin biosynthesis" EXACT [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0052324 name: plant-type cell wall cellulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall cellulose biosynthesis" EXACT [] synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED [] is_a: GO:0030244 ! cellulose biosynthetic process is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0052325 name: cell wall pectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall pectin biosynthesis" EXACT [] synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045489 ! pectin biosynthetic process is_a: GO:0052546 ! cell wall pectin metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0052326 name: obsolete interaction with symbiont via protein secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "interaction with symbiont via protein secreted by type IV secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052327 name: obsolete interaction with symbiont via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "interaction with symbiont via protein secreted by type II secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052328 name: obsolete interaction with symbiont via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "interaction with symbiont via protein secreted by type III secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052330 name: positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052518 alt_id: GO:0052529 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "enhancement of other organism programmed cell death by organism" RELATED [] synonym: "positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0052331 name: hemolysis in other organism involved in symbiotic interaction namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354] synonym: "haemolysis in other organism involved in symbiotic interaction" EXACT [] synonym: "hemolysin activity" RELATED [] synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" RELATED [] synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" RELATED [CL:0000232] synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" RELATED [CL:0000232] synonym: "hemolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "hemolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] is_a: GO:0044179 ! hemolysis in other organism is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0044179 ! hemolysis in other organism intersection_of: part_of GO:0044403 ! symbiotic process relationship: part_of GO:0044403 ! symbiotic process [Term] id: GO:0052332 name: modification by organism of membrane in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification by organism of cell membrane in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modification by organism of cell membrane in other organism involved in symbiotic interaction" NARROW [GOC:bf, GOC:jl] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052333 name: modification by organism of cell wall of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall of other organism" RELATED [] synonym: "modification by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052334 name: modification by organism of cytoskeleton of other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification by organism of cytoskeleton of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052188 ! modification of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052335 name: modification by host of symbiont cytoskeleton namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism involved in symbiotic interaction [Term] id: GO:0052336 name: modification by host of symbiont cell wall namespace: biological_process def: "The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "metabolism of symbiont cell wall by organism" EXACT [] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052337 name: modification by host of symbiont membrane namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a symbiont cellular membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modification by host of symbiont cell membrane" NARROW [GOC:bf, GOC:jl] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052332 ! modification by organism of membrane in other organism involved in symbiotic interaction [Term] id: GO:0052338 name: disruption by host of symbiont cell wall namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of symbiont cell wall by organism" EXACT [] synonym: "degradation of symbiont cell wall by organism" EXACT [] synonym: "disassembly by host of symbiont cell wall" EXACT [] is_a: GO:0052336 ! modification by host of symbiont cell wall is_a: GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction is_a: GO:0052367 ! disruption by host of symbiont cellular component [Term] id: GO:0052339 name: disruption by organism of cell wall of other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "disassembly by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052333 ! modification by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052340 name: catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0030245 ! cellulose catabolic process is_a: GO:0044347 ! cell wall polysaccharide catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction relationship: part_of GO:0044278 ! cell wall disruption in other organism relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052341 name: catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction relationship: part_of GO:0044278 ! cell wall disruption in other organism relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052342 name: catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006039 ! cell wall chitin catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction relationship: part_of GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0052343 name: obsolete positive regulation by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont phytoalexin production" EXACT [] is_obsolete: true [Term] id: GO:0052344 name: positive regulation by symbiont of host phytoalexin production namespace: biological_process alt_id: GO:0052329 def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host phytoalexin production" NARROW [] synonym: "positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD [] synonym: "stimulation by symbiont of host phytoalexin production" NARROW [] synonym: "up regulation by symbiont of host phytoalexin production" EXACT [] synonym: "up-regulation by symbiont of host phytoalexin production" EXACT [] synonym: "upregulation by symbiont of host phytoalexin production" EXACT [] is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052346 name: obsolete positive regulation by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont nitric oxide production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052349 name: obsolete positive regulation by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont reactive oxygen species production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT [] synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052350 name: obsolete induction by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of induced systemic resistance in symbiont" EXACT [] synonym: "activation by organism of ISR in symbiont" EXACT [] synonym: "induction by organism of induced systemic resistance in symbiont" EXACT [] synonym: "induction by organism of ISR in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052351 name: obsolete induction by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of SAR in symbiont" EXACT [] synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT [] synonym: "induction by organism of SAR in symbiont" EXACT [] synonym: "induction by organism of systemic acquired resistance in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052352 name: biosynthesis by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052226 ! biosynthesis of substance in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052353 name: catabolism by host of symbiont carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052360 ! catabolism by host of symbiont macromolecule is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate [Term] id: GO:0052354 name: catabolism by organism of carbohydrate in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044041 ! multi-organism carbohydrate catabolic process is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052355 name: catabolism by host of symbiont cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052408 ! metabolism by host of symbiont cell wall cellulose relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall [Term] id: GO:0052356 name: catabolism by host of symbiont cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052410 ! metabolism by host of symbiont cell wall chitin relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall [Term] id: GO:0052357 name: catabolism by host of symbiont cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052412 ! metabolism by host of symbiont cell wall pectin relationship: part_of GO:0052338 ! disruption by host of symbiont cell wall [Term] id: GO:0052358 name: catabolism by host of symbiont glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052359 ! catabolism by organism of glucan in other organism involved in symbiotic interaction is_a: GO:0052414 ! metabolism by host of symbiont glucan [Term] id: GO:0052359 name: catabolism by organism of glucan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052360 name: catabolism by host of symbiont macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052364 ! catabolism by host of substance in symbiont is_a: GO:0052416 ! metabolism by host of symbiont macromolecule [Term] id: GO:0052361 name: catabolism by organism of macromolecule in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of macromolecule in other organism during symbiotic interaction" RELATED [goc:dph] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052362 name: catabolism by host of symbiont protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052360 ! catabolism by host of symbiont macromolecule is_a: GO:0052363 ! catabolism by organism of protein in other organism involved in symbiotic interaction is_a: GO:0052417 ! metabolism by host of symbiont protein [Term] id: GO:0052363 name: catabolism by organism of protein in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0030163 ! protein catabolic process is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052364 name: catabolism by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052227 ! catabolism of substance in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052365 name: catabolism by host of symbiont xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate is_a: GO:0052366 ! catabolism by organism of xylan in other organism involved in symbiotic interaction is_a: GO:0052420 ! metabolism by host of symbiont xylan [Term] id: GO:0052366 name: catabolism by organism of xylan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0045493 ! xylan catabolic process is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052367 name: disruption by host of symbiont cellular component namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of symbiont cellular component by organism" EXACT [] synonym: "catabolism of symbiont structural constituent by organism" EXACT [] synonym: "degradation of symbiont cellular component by organism" EXACT [] synonym: "disassembly by host of symbiont cellular component" RELATED [] is_a: GO:0052187 ! modification by host of symbiont cellular component is_a: GO:0052368 ! disruption by organism of cellular component in other organism involved in symbiotic interaction [Term] id: GO:0052368 name: disruption by organism of cellular component in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] synonym: "catabolism of cellular component in other organism" EXACT [] synonym: "catabolism of structural constituent in other organism" EXACT [] synonym: "degradation of cellular component in other organism" EXACT [] synonym: "disassembly by organism of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "disassembly by organism of cellular component in other organism involved in symbiotic interaction" RELATED [] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052371 name: regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0044409 ! entry into host [Term] id: GO:0052372 name: modulation by symbiont of entry into host namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052373 name: negative regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052374 name: negative regulation by symbiont of entry into host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of entry into host" EXACT [] synonym: "down-regulation by symbiont of entry into host" EXACT [] synonym: "downregulation by symbiont of entry into host" EXACT [] synonym: "inhibition by symbiont of entry into host" NARROW [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052375 name: obsolete evasion or tolerance by organism of symbiont-produced nitric oxide namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of symbiont NO" EXACT [] synonym: "evasion or tolerance by organism of symbiont-produced nitric oxide" EXACT [] synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT [] synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT [] synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT [] is_obsolete: true [Term] id: GO:0052377 name: obsolete evasion or tolerance by organism of symbiont-produced phytoalexins namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT [] synonym: "evasion or tolerance by organism of symbiont-produced phytoalexins" EXACT [] synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT [] synonym: "symbiont phytoalexin detoxification" NARROW [] is_obsolete: true [Term] id: GO:0052379 name: modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" RELATED [] synonym: "modulation by organism of entry into other organism via phagocytosis during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0052380 name: modulation by symbiont of entry into host via phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into host via host phagocytosis" EXACT [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052381 name: tRNA dimethylallyltransferase activity namespace: molecular_function alt_id: GO:0004811 def: "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75] comment: Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC 2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate. synonym: "dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity" EXACT systematic_synonym [EC:2.5.1.75] synonym: "tRNA isopentenyltransferase activity" RELATED [GOC:mah, GOC:vw] synonym: "tRNA prenyltransferase activity" BROAD [EC:2.5.1.75] xref: EC:2.5.1.75 xref: MetaCyc:RXN0-6274 xref: Reactome:R-HSA-6784462 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs" xref: Reactome:R-HSA-6787567 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA creation_date: 2010-07-23T03:07:33Z [Term] id: GO:0052383 name: obsolete induction by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont innate immune response" EXACT [] synonym: "activation by organism of symbiont innate immunity" EXACT [] synonym: "induction by organism of symbiont innate immune response" EXACT [] synonym: "induction by organism of symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052384 name: obsolete evasion or tolerance by organism of symbiont-produced reactive oxygen species namespace: biological_process def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW [] synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT [] synonym: "evasion or tolerance by organism of symbiont-produced reactive oxygen species" EXACT [] synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT [] synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT [] synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT [] synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT [] synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT [] synonym: "evasion or tolerance of symbiont-produced AOS" EXACT [] synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT [] synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT [] synonym: "evasion or tolerance of symbiont-produced ROS" EXACT [] is_obsolete: true [Term] id: GO:0052386 name: cell wall thickening namespace: biological_process def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06] is_a: GO:0042545 ! cell wall modification [Term] id: GO:0052387 name: obsolete induction by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont apoptosis" EXACT [] synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT [] synonym: "induction by organism of symbiont apoptosis" EXACT [] synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052390 name: induction by symbiont of host innate immune response namespace: biological_process alt_id: GO:0052166 alt_id: GO:0052305 alt_id: GO:0052382 def: "The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of host innate immune response" EXACT [] synonym: "activation by organism of host innate immunity" EXACT [] synonym: "activation by symbiont of host innate immunity" EXACT [] synonym: "induction by organism of host innate immune response" RELATED [] synonym: "induction by organism of innate immune response in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by symbiont of host innate immunity" EXACT [] synonym: "induction of host innate immunity" EXACT [] synonym: "positive regulation by symbiont of host innate immune response" RELATED [] synonym: "positive regulation by symbiont of host innate immunity" RELATED [] synonym: "positive regulation of host innate immune response" RELATED [] synonym: "positive regulation of innate immune response in other organism" BROAD [] synonym: "stimulation by symbiont of host innate immunity" RELATED [] synonym: "up regulation by symbiont of host innate immunity" RELATED [] synonym: "up-regulation by symbiont of host innate immunity" RELATED [] synonym: "upregulation by symbiont of host innate immunity" EXACT [] is_a: GO:0052559 ! induction by symbiont of host immune response [Term] id: GO:0052391 name: induction by symbiont of defense-related host calcium ion flux namespace: biological_process alt_id: GO:0052065 alt_id: GO:0052265 alt_id: GO:0052389 def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of host Ca2+ flux" EXACT [] synonym: "activation by organism of host calcium ion flux" EXACT [] synonym: "activation by symbiont of defense-related host calcium ion flux" EXACT [] synonym: "induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] synonym: "induction by organism of host Ca2+ flux" EXACT [] synonym: "positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of defense-related host Ca2+ flux" RELATED [] synonym: "positive regulation by symbiont of defense-related host calcium ion flux" RELATED [] synonym: "stimulation by symbiont of defense-related host calcium ion flux" RELATED [] synonym: "up regulation by symbiont of defense-related host calcium ion flux" RELATED [] synonym: "up-regulation by symbiont of defense-related host calcium ion flux" RELATED [] synonym: "upregulation by symbiont of defense-related host calcium ion flux" RELATED [] is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux [Term] id: GO:0052392 name: obsolete induction by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont Ca2+ flux" EXACT [] synonym: "activation by organism of symbiont calcium ion flux" EXACT [] synonym: "induction by organism of defense-related symbiont calcium ion flux" EXACT [] synonym: "induction by organism of symbiont Ca2+ flux" EXACT [] is_obsolete: true [Term] id: GO:0052393 name: obsolete induction by host of symbiont defense response namespace: biological_process def: "OBSOLETE. The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. synonym: "activation of symbiont defense response" EXACT [] is_obsolete: true [Term] id: GO:0052394 name: obsolete induction by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT [] synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT [] synonym: "induction by organism of defense-related symbiont cell wall thickening" EXACT [] synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT [] is_obsolete: true [Term] id: GO:0052395 name: obsolete induction by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT [] synonym: "activation by organism of defense-related symbiont NO production" EXACT [] synonym: "induction by organism of defense-related symbiont nitric oxide production" EXACT [] synonym: "induction by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052396 name: obsolete induction by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT [] synonym: "induction by organism of symbiont non-apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052398 name: obsolete induction by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont phytoalexin production" EXACT [] synonym: "induction by organism of symbiont phytoalexin production" EXACT [] is_obsolete: true [Term] id: GO:0052399 name: obsolete induction by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont programmed cell death" EXACT [] synonym: "induction by organism of symbiont programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052401 name: obsolete induction by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "activation by organism of defense-related symbiont AOS production" EXACT [] synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT [] synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "activation by organism of defense-related symbiont ROI production" EXACT [] synonym: "activation by organism of defense-related symbiont ROS production" EXACT [] synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "induction by organism of defense-related symbiont AOS production" EXACT [] synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "induction by organism of defense-related symbiont reactive oxygen species production" EXACT [] synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "induction by organism of defense-related symbiont ROI production" EXACT [] synonym: "induction by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052402 name: obsolete induction by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT [] synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT [] synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT [] synonym: "induction by organism of symbiont resistance gene-dependent defense response" EXACT [] is_obsolete: true [Term] id: GO:0052403 name: negative regulation by host of symbiont catalytic activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by host of symbiont enzyme activity" EXACT [] synonym: "down-regulation by host of symbiont enzyme activity" EXACT [] synonym: "downregulation by host of symbiont enzyme activity" EXACT [] synonym: "inhibition by host of symbiont enzyme activity" NARROW [] synonym: "inhibition of symbiont enzyme activity" EXACT [] synonym: "negative regulation by host of symbiont enzyme activity" EXACT [] is_a: GO:0052199 ! negative regulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052405 ! negative regulation by host of symbiont molecular function is_a: GO:0052422 ! modulation by host of symbiont catalytic activity intersection_of: GO:0052422 ! modulation by host of symbiont catalytic activity intersection_of: negatively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0052404 name: negative regulation by host of symbiont peptidase activity namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by host of symbiont protease activity" NARROW [] synonym: "down-regulation by host of symbiont protease activity" NARROW [] synonym: "downregulation by host of symbiont protease activity" NARROW [] synonym: "inhibition by host of symbiont protease activity" NARROW [] synonym: "inhibition of symbiont protease activity" NARROW [] synonym: "negative regulation by host of symbiont protease activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0052180 ! negative regulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity is_a: GO:0052427 ! modulation by host of symbiont peptidase activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0052405 name: negative regulation by host of symbiont molecular function namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "down regulation by host of symbiont protein function" EXACT [] synonym: "down-regulation by host of symbiont protein function" EXACT [] synonym: "downregulation by host of symbiont protein function" EXACT [] synonym: "inhibition by host of symbiont protein function" NARROW [] synonym: "inhibition of symbiont protein function" EXACT [] synonym: "negative regulation by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0052204 ! negative regulation of molecular function in other organism involved in symbiotic interaction is_a: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: negatively_regulates GO:0003674 ! molecular_function [Term] id: GO:0052406 name: metabolism by host of symbiont carbohydrate namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052416 ! metabolism by host of symbiont macromolecule [Term] id: GO:0052407 name: metabolism by organism of carbohydrate in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044040 ! multi-organism carbohydrate metabolic process is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052408 name: metabolism by host of symbiont cell wall cellulose namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction [Term] id: GO:0052409 name: metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0044043 ! multi-organism glucan metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process [Term] id: GO:0052410 name: metabolism by host of symbiont cell wall chitin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction [Term] id: GO:0052411 name: metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052412 name: metabolism by host of symbiont cell wall pectin namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction [Term] id: GO:0052413 name: metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0052414 name: metabolism by host of symbiont glucan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052415 ! metabolism by organism of glucan in other organism involved in symbiotic interaction [Term] id: GO:0052415 name: metabolism by organism of glucan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044043 ! multi-organism glucan metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052416 name: metabolism by host of symbiont macromolecule namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction is_a: GO:0052419 ! metabolism by host of substance in symbiont [Term] id: GO:0052417 name: metabolism by host of symbiont protein namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052416 ! metabolism by host of symbiont macromolecule is_a: GO:0052418 ! metabolism by organism of protein in other organism involved in symbiotic interaction [Term] id: GO:0052418 name: metabolism by organism of protein in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0019538 ! protein metabolic process is_a: GO:0052229 ! metabolism of macromolecule in other organism involved in symbiotic interaction [Term] id: GO:0052419 name: metabolism by host of substance in symbiont namespace: biological_process def: "The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052214 ! metabolism of substance in other organism involved in symbiotic interaction [Term] id: GO:0052420 name: metabolism by host of symbiont xylan namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate is_a: GO:0052421 ! metabolism by organism of xylan in other organism involved in symbiotic interaction [Term] id: GO:0052421 name: metabolism by organism of xylan in other organism involved in symbiotic interaction namespace: biological_process def: "The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "metabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process is_a: GO:0045491 ! xylan metabolic process is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism involved in symbiotic interaction [Term] id: GO:0052422 name: modulation by host of symbiont catalytic activity namespace: biological_process def: "The process in which a host organism effects a change in the enzyme activity of its symbiont organism." [GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb] is_a: GO:0052203 ! modulation of catalytic activity in other organism involved in symbiotic interaction is_a: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: regulates GO:0003824 ! catalytic activity [Term] id: GO:0052424 name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052425 name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052426 name: obsolete modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system namespace: biological_process def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system" EXACT [] is_obsolete: true [Term] id: GO:0052427 name: modulation by host of symbiont peptidase activity namespace: biological_process def: "The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by host of symbiont protease activity" NARROW [GOC:bf] is_a: GO:0052198 ! modulation of peptidase activity in other organism involved in symbiotic interaction is_a: GO:0052422 ! modulation by host of symbiont catalytic activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: regulates GO:0008233 ! peptidase activity [Term] id: GO:0052428 name: modulation by host of symbiont molecular function namespace: biological_process def: "The process in which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] synonym: "modification by host of symbiont molecular function" EXACT [] synonym: "modification by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052205 ! modulation of molecular function in other organism involved in symbiotic interaction [Term] id: GO:0052429 name: obsolete modulation by organism of symbiont B-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont B-cell mediated immune response" EXACT [] synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052430 name: modulation by host of symbiont RNA levels namespace: biological_process def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052249 ! modulation of RNA levels in other organism involved in symbiotic interaction [Term] id: GO:0052431 name: obsolete modulation by organism of symbiont T-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont T-cell mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052432 name: obsolete modulation by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont apoptosis" EXACT [] synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052433 name: modulation by organism of apoptotic process in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "modulation by organism of apoptosis in other organism involved in symbiotic interaction" NARROW [] synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] is_a: GO:0044532 ! modulation of apoptotic process in other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052434 name: obsolete modulation by organism of symbiont cell-mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont cell-based immune response" EXACT [] synonym: "modulation by organism of symbiont cell-mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052435 name: obsolete modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT [] synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052436 name: obsolete modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT [] synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT [] is_obsolete: true [Term] id: GO:0052437 name: obsolete modulation by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT [] synonym: "modulation by organism of defense-related symbiont calcium ion flux" EXACT [] is_obsolete: true [Term] id: GO:0052438 name: obsolete modulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052439 name: obsolete modulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052440 name: obsolete modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052442 name: obsolete modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052444 name: obsolete modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052446 name: obsolete modulation by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont cell wall thickening" EXACT [] synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED [] is_obsolete: true [Term] id: GO:0052447 name: obsolete modulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont ethylene-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052448 name: obsolete modulation by organism of ethylene levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of ethylene levels in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052450 name: obsolete modulation by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of induced systemic resistance in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052451 name: obsolete modulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont inflammatory response" EXACT [] is_obsolete: true [Term] id: GO:0052452 name: obsolete modulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont innate immunity" EXACT [] synonym: "modulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052453 name: obsolete modulation by organism of symbiont intracellular transport namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont intracellular transport" EXACT [] synonym: "modulation of symbiont intracellular trafficking" EXACT [] is_obsolete: true [Term] id: GO:0052454 name: obsolete modulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT [] synonym: "modulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052455 name: obsolete modulation by organism of jasmonic acid levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of jasmonic acid levels in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052457 name: obsolete modulation by organism of defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont nitric oxide production" EXACT [] synonym: "modulation by organism of defense-related symbiont NO production" EXACT [] is_obsolete: true [Term] id: GO:0052458 name: obsolete modulation by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont non-apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052460 name: modulation by host of nutrient release from symbiont namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont [Term] id: GO:0052461 name: obsolete modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052462 name: modulation by host of symbiont phagocytosis namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: regulates GO:0006909 ! phagocytosis [Term] id: GO:0052463 name: obsolete modulation by organism of symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont phytoalexin production" EXACT [] is_obsolete: true [Term] id: GO:0052464 name: obsolete modulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont programmed cell death" EXACT [] synonym: "modulation of symbiont HR" BROAD [] synonym: "modulation of symbiont hypersensitive response" NARROW [] synonym: "modulation of symbiont PCD" EXACT [] is_obsolete: true [Term] id: GO:0052465 name: obsolete modulation by organism of defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT [] synonym: "modulation by organism of defense-related symbiont AOS production" EXACT [] synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT [] synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT [] synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] synonym: "modulation by organism of defense-related symbiont reactive oxygen species production" EXACT [] synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT [] synonym: "modulation by organism of defense-related symbiont ROI production" EXACT [] synonym: "modulation by organism of defense-related symbiont ROS production" EXACT [] is_obsolete: true [Term] id: GO:0052466 name: obsolete modulation by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT [] synonym: "modulation by organism of symbiont resistance gene-dependent defense response" EXACT [] is_obsolete: true [Term] id: GO:0052467 name: obsolete modulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT [] synonym: "modulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052468 name: obsolete modulation by organism of salicylic acid levels in symbiont namespace: biological_process def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of salicylic acid levels in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052470 name: obsolete modulation by host of symbiont signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0052471 name: obsolete modulation by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of systemic acquired resistance in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052472 name: modulation by host of symbiont transcription namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription." [GOC:mtg_pamgo_17jul06] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology is_a: GO:0052312 ! modulation of transcription in other organism involved in symbiotic interaction [Term] id: GO:0052473 name: obsolete negative regulation by organism of symbiont B-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont B-cell mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052474 name: obsolete negative regulation by organism of symbiont T-cell mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont T-cell mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052475 name: obsolete negative regulation by organism of symbiont cell-mediated immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT [] synonym: "negative regulation by organism of symbiont cell-mediated immune response" EXACT [] is_obsolete: true [Term] id: GO:0052476 name: obsolete negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. synonym: "negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052477 name: obsolete negative regulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of defense-related symbiont callose deposition" EXACT [] synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052478 name: obsolete negative regulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. synonym: "negative regulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052479 name: obsolete negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052480 name: obsolete negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052481 name: obsolete negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] synonym: "negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052482 name: defense response by cell wall thickening namespace: biological_process def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06] synonym: "cell wall thickening during defense response" RELATED [GOC:dph] is_a: GO:0006952 ! defense response is_a: GO:0033554 ! cellular response to stress is_a: GO:0052386 ! cell wall thickening [Term] id: GO:0052483 name: negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "downregulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [] synonym: "inhibition by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" NARROW [] synonym: "negative regulation by organism of entry into cell of other organism via other organism phagocytosis during symbiotic interaction" RELATED [] synonym: "negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0030682 ! mitigation of host defenses by symbiont is_a: GO:0052373 ! negative regulation by organism of entry into other organism involved in symbiotic interaction is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction [Term] id: GO:0052484 name: obsolete negative regulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont ethylene-mediated defense response" EXACT [] synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052485 name: obsolete negative regulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont inflammatory response" EXACT [] is_obsolete: true [Term] id: GO:0052486 name: obsolete negative regulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont innate immunity" EXACT [] synonym: "negative regulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052487 name: obsolete negative regulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052488 name: obsolete negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT [] synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT [] synonym: "suppression of MAMP induced symbiont innate immunity" EXACT [] synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT [] synonym: "suppression of PAMP induced symbiont innate immunity" EXACT [] synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT [] synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052489 name: negative regulation by host of symbiont programmed cell death namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by host of symbiont programmed cell death" EXACT [] synonym: "down-regulation by host of symbiont programmed cell death" EXACT [] synonym: "downregulation by host of symbiont programmed cell death" EXACT [] synonym: "inhibition by host of symbiont programmed cell death" NARROW [] synonym: "inhibition of symbiont programmed cell death" EXACT [] is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052490 name: negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "down-regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "downregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "inhibition by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] synonym: "inhibition of programmed cell death in other organism" EXACT [] synonym: "negative regulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction [Term] id: GO:0052491 name: obsolete negative regulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] synonym: "negative regulation of symbiont SA-mediated defense response" EXACT [] synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT [] synonym: "suppression of symbiont SA mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052492 name: obsolete negative regulation by host of symbiont signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "down regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "downregulation by host of symbiont signal transduction pathway" EXACT [] synonym: "inhibition by host of symbiont signal transduction pathway" NARROW [] synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052494 name: occlusion by host of symbiont vascular system namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] is_a: GO:0052183 ! modification by host of symbiont structure is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052495 name: occlusion by organism of vascular system in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] synonym: "occlusion by organism of vascular system in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052185 ! modification of structure of other organism involved in symbiotic interaction [Term] id: GO:0052496 name: occlusion by host of symbiont xylem namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] is_a: GO:0052494 ! occlusion by host of symbiont vascular system is_a: GO:0052497 ! occlusion by organism of xylem in other organism involved in symbiotic interaction [Term] id: GO:0052497 name: occlusion by organism of xylem in other organism involved in symbiotic interaction namespace: biological_process def: "The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "occlusion by organism of xylem in other organism during symbiotic interaction" RELATED [GOC:dph] is_a: GO:0052495 ! occlusion by organism of vascular system in other organism involved in symbiotic interaction [Term] id: GO:0052498 name: obsolete pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT [] synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT [] synonym: "MAMP dependent activation of symbiont innate immunity" EXACT [] synonym: "MAMP dependent induction of symbiont innate immunity" EXACT [] synonym: "PAMP dependent activation of symbiont innate immunity" EXACT [] synonym: "PAMP dependent induction of symbiont innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT [] synonym: "pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052499 name: obsolete pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity" EXACT [] is_obsolete: true [Term] id: GO:0052500 name: obsolete positive regulation by organism of symbiont apoptosis namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont apoptosis" EXACT [] synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052501 name: positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction namespace: biological_process alt_id: GO:0052388 def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "induction by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "induction by organism of apoptosis in other organism involved in symbiotic interaction" EXACT [] synonym: "induction by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "positive regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "positive regulation by organism of apoptosis in other organism involved in symbiotic interaction" NARROW [] synonym: "positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction" NARROW [] synonym: "positive regulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] synonym: "stimulation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of apoptosis in other organism during symbiotic interaction" RELATED [] is_a: GO:0044533 ! positive regulation of apoptotic process in other organism is_a: GO:0052151 ! positive regulation by symbiont of host apoptotic process [Term] id: GO:0052502 name: obsolete positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052503 name: obsolete positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT [] synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT [] is_obsolete: true [Term] id: GO:0052504 name: obsolete positive regulation by organism of defense-related symbiont callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW [] synonym: "induction by organism of defense-related symbiont callose deposition" NARROW [] synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT [] synonym: "positive regulation by organism of defense-related symbiont callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052505 name: obsolete positive regulation by organism of defense-related symbiont cell wall callose deposition namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW [] synonym: "positive regulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] is_obsolete: true [Term] id: GO:0052506 name: obsolete positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052507 name: obsolete positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052508 name: obsolete positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] is_obsolete: true [Term] id: GO:0052511 name: obsolete positive regulation by organism of symbiont ethylene-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW [] synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW [] synonym: "positive regulation by organism of symbiont ethylene-mediated defense response" EXACT [] synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW [] is_obsolete: true [Term] id: GO:0052512 name: obsolete positive regulation by organism of hormone or growth regulator levels in symbiont namespace: biological_process def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT [] synonym: "positive regulation by organism of hormone or growth regulator levels in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052514 name: obsolete positive regulation by organism of symbiont inflammatory response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont inflammatory response" EXACT [] is_obsolete: true [Term] id: GO:0052515 name: obsolete positive regulation by organism of symbiont innate immunity namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont innate immunity" EXACT [] synonym: "positive regulation of symbiont innate immune response" EXACT [] is_obsolete: true [Term] id: GO:0052516 name: obsolete positive regulation by organism of symbiont jasmonic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of symbiont JA-mediated defense response" NARROW [] synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT [] synonym: "positive regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052517 name: obsolete positive regulation by organism of symbiont non-apoptotic programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont non-apoptotic programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052519 name: positive regulation by host of nutrient release from symbiont namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of nutrient release from symbiont" NARROW [] synonym: "promotion of nutrient release from symbiont" EXACT [] synonym: "stimulation by host of nutrient release from symbiont" NARROW [] synonym: "up regulation by host of nutrient release from symbiont" EXACT [] synonym: "up-regulation by host of nutrient release from symbiont" EXACT [] synonym: "upregulation by host of nutrient release from symbiont" EXACT [] is_a: GO:0052460 ! modulation by host of nutrient release from symbiont is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052520 name: positive regulation by organism of nutrient release from other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "promotion of nutrient release from other organism" EXACT [] synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] is_a: GO:0052313 ! modulation of nutrient release from other organism involved in symbiotic interaction [Term] id: GO:0052521 name: positive regulation by host of symbiont phagocytosis namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by host of symbiont phagocytosis" NARROW [] synonym: "stimulation by host of symbiont phagocytosis" NARROW [] synonym: "up regulation by host of symbiont phagocytosis" EXACT [] synonym: "up-regulation by host of symbiont phagocytosis" EXACT [] synonym: "upregulation by host of symbiont phagocytosis" EXACT [] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0052462 ! modulation by host of symbiont phagocytosis intersection_of: GO:0051851 ! modification by host of symbiont morphology or physiology intersection_of: positively_regulates GO:0006909 ! phagocytosis [Term] id: GO:0052522 name: positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0052231 ! modulation of phagocytosis in other organism involved in symbiotic interaction [Term] id: GO:0052523 name: obsolete positive regulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "enhancement or induction of symbiont programmed cell death" EXACT [] synonym: "positive regulation by organism of symbiont programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052524 name: obsolete positive regulation by organism of symbiont salicylic acid-mediated defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of symbiont SA-mediated defense response" NARROW [] synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW [] synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT [] synonym: "positive regulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] is_obsolete: true [Term] id: GO:0052525 name: obsolete positive regulation by host of symbiont signal transduction pathway namespace: biological_process def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "activation by host of symbiont signal transduction pathway" NARROW [] synonym: "stimulation by host of symbiont signal transduction pathway" NARROW [] synonym: "up regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT [] synonym: "upregulation by host of symbiont signal transduction pathway" EXACT [] is_obsolete: true [Term] id: GO:0052528 name: obsolete upregulation by organism of symbiont programmed cell death namespace: biological_process def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "enhancement of symbiont programmed cell death by organism" EXACT [] synonym: "upregulation by organism of symbiont programmed cell death" EXACT [] is_obsolete: true [Term] id: GO:0052530 name: obsolete positive regulation by organism of symbiont resistance gene-dependent defense response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT [] synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT [] synonym: "positive regulation by organism of symbiont resistance gene-dependent defense response" EXACT [] is_obsolete: true [Term] id: GO:0052531 name: obsolete positive regulation by organism of defense-related symbiont calcium ion flux namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT [] synonym: "positive regulation by organism of defense-related symbiont calcium ion flux" EXACT [] is_obsolete: true [Term] id: GO:0052534 name: obsolete positive regulation by organism of induced systemic resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of induced systemic resistance in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052536 name: obsolete positive regulation by organism of systemic acquired resistance in symbiont namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of systemic acquired resistance in symbiont" EXACT [] is_obsolete: true [Term] id: GO:0052540 name: obsolete positive regulation by organism of defense-related symbiont cell wall thickening namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of defense-related symbiont cell wall thickening" EXACT [] synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT [] is_obsolete: true [Term] id: GO:0052541 name: plant-type cell wall cellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732] synonym: "cell wall cellulose metabolism" EXACT [] synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT [] is_a: GO:0030243 ! cellulose metabolic process is_a: GO:0034406 ! cell wall beta-glucan metabolic process relationship: part_of GO:0009664 ! plant-type cell wall organization [Term] id: GO:0052542 name: defense response by callose deposition namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose deposition during defense response" RELATED [GOC:dph] synonym: "callose localization during defense response" RELATED [] is_a: GO:0006952 ! defense response is_a: GO:0052545 ! callose localization [Term] id: GO:0052543 name: callose deposition in cell wall namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose localization in cell wall" EXACT [] synonym: "cell wall callose deposition" EXACT [] synonym: "cell wall callose localization" EXACT [] is_a: GO:0052386 ! cell wall thickening is_a: GO:0052545 ! callose localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0052544 name: defense response by callose deposition in cell wall namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] synonym: "callose deposition in cell wall during defense response" RELATED [GOC:dph] synonym: "callose localization in cell wall during defense response" EXACT [] synonym: "cell wall callose deposition during defense response" EXACT [] synonym: "cell wall callose localization during defense response" EXACT [] is_a: GO:0052482 ! defense response by cell wall thickening is_a: GO:0052542 ! defense response by callose deposition is_a: GO:0052543 ! callose deposition in cell wall intersection_of: GO:0052543 ! callose deposition in cell wall intersection_of: part_of GO:0006952 ! defense response relationship: part_of GO:0006952 ! defense response [Term] id: GO:0052545 name: callose localization namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] synonym: "callose localisation" EXACT [GOC:mah] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0052546 name: cell wall pectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] synonym: "cell wall pectin metabolism" EXACT [] synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT [] synonym: "pectin metabolism during cell wall biogenesis" EXACT [] synonym: "plant-type cell wall pectin metabolic process" EXACT [] is_a: GO:0045488 ! pectin metabolic process relationship: part_of GO:0009664 ! plant-type cell wall organization [Term] id: GO:0052547 name: regulation of peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai] synonym: "peptidase regulator activity" RELATED [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008233 ! peptidase activity relationship: regulates GO:0008233 ! peptidase activity [Term] id: GO:0052548 name: regulation of endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd] synonym: "protease regulator activity" NARROW [] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004175 ! endopeptidase activity relationship: regulates GO:0004175 ! endopeptidase activity [Term] id: GO:0052553 name: modulation by symbiont of host immune response namespace: biological_process alt_id: GO:0052552 def: "Any process in which a symbiont modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052572 ! response to host immune response [Term] id: GO:0052554 name: obsolete modulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "modulation by organism of symbiont immune response" EXACT [] is_obsolete: true [Term] id: GO:0052557 name: obsolete positive regulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "positive regulation by organism of symbiont immune response" EXACT [] is_obsolete: true [Term] id: GO:0052559 name: induction by symbiont of host immune response namespace: biological_process alt_id: GO:0052555 alt_id: GO:0052556 alt_id: GO:0052558 def: "Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "activation by symbiont of host immune response" EXACT [] synonym: "induction by organism of immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "positive regulation by symbiont of host immune response" RELATED [] synonym: "stimulation by symbiont of host immune response" RELATED [] synonym: "up regulation by symbiont of host immune response" RELATED [] synonym: "up-regulation by symbiont of host immune response" RELATED [] synonym: "upregulation by symbiont of host immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052560 name: obsolete induction by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "induction by organism of symbiont immune response" EXACT [] is_obsolete: true [Term] id: GO:0052562 name: suppression by symbiont of host immune response namespace: biological_process alt_id: GO:0052561 def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "down regulation by symbiont of host immune response" EXACT [] synonym: "down-regulation by symbiont of host immune response" EXACT [] synonym: "downregulation by symbiont of host immune response" EXACT [] synonym: "inhibition by symbiont of host immune response" NARROW [] synonym: "negative regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] synonym: "negative regulation by symbiont of host immune response" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response [Term] id: GO:0052563 name: obsolete negative regulation by organism of symbiont immune response namespace: biological_process def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "negative regulation by organism of symbiont immune response" EXACT [] is_obsolete: true [Term] id: GO:0052565 name: response to defense-related host nitric oxide production namespace: biological_process alt_id: GO:0052551 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "defense response to host innate immune response nitric oxide production" NARROW [] synonym: "response to defense-related host nitric oxide production" RELATED [] synonym: "response to defense-related nitric oxide production by other organism involved in symbiotic interaction" BROAD [] is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0052572 ! response to host immune response is_a: GO:0071500 ! cellular response to nitrosative stress [Term] id: GO:0052568 name: obsolete response to symbiont phytoalexin production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "response to symbiont phytoalexin production" EXACT [] is_obsolete: true [Term] id: GO:0052569 name: obsolete response to defense-related symbiont nitric oxide production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "response to defense-related symbiont nitric oxide production" EXACT [] is_obsolete: true [Term] id: GO:0052570 name: obsolete response to defense-related symbiont reactive oxygen species production namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "response to defense-related symbiont reactive oxygen species production" EXACT [] is_obsolete: true [Term] id: GO:0052571 name: obsolete response to symbiont immune response namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] comment: This term was made obsolete because it does not represent a real biological process. synonym: "response to symbiont immune response" EXACT [] is_obsolete: true [Term] id: GO:0052572 name: response to host immune response namespace: biological_process alt_id: GO:0052564 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "response to immune response of other organism involved in symbiotic interaction" BROAD [] is_a: GO:0052200 ! response to host defenses [Term] id: GO:0052573 name: UDP-D-galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "UDP-D-galactopyranose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactopyranose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process creation_date: 2010-07-23T03:29:57Z [Term] id: GO:0052574 name: UDP-D-galactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "UDP-D-galactopyranose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactopyranose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-D-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "UDP-galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] synonym: "uridine diphosphate galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0052573 ! UDP-D-galactose metabolic process creation_date: 2010-07-23T03:52:40Z [Term] id: GO:0052575 name: carbohydrate localization namespace: biological_process def: "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah] synonym: "carbohydrate localisation" EXACT [PMID:10758476] is_a: GO:0033036 ! macromolecule localization creation_date: 2010-07-23T04:08:13Z [Term] id: GO:0052576 name: carbohydrate storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [PMID:10758476] is_a: GO:0052575 ! carbohydrate localization creation_date: 2010-07-23T04:16:56Z [Term] id: GO:0052577 name: germacrene-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate." [EC:4.2.3.22] synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity" EXACT [EC:4.2.3.22] xref: EC:4.2.3.22 xref: KEGG_REACTION:R07648 xref: MetaCyc:RXN-8562 is_a: GO:0010334 ! sesquiterpene synthase activity created_by: gwg creation_date: 2010-08-09T01:39:02Z [Term] id: GO:0052578 name: alpha-farnesene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574] synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574] xref: MetaCyc:RXN-8574 is_a: GO:0010334 ! sesquiterpene synthase activity created_by: gwg creation_date: 2010-08-09T01:39:42Z [Term] id: GO:0052579 name: (+)-pulegone reductase, (+)-isomenthone as substrate, activity namespace: molecular_function def: "Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5164] synonym: "(+)-isomenthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81] xref: EC:1.3.1.81 xref: MetaCyc:RXN-5164 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2010-08-09T04:28:00Z [Term] id: GO:0052580 name: (+)-pulegone reductase, (-)-menthone as substrate, activity namespace: molecular_function def: "Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5163] synonym: "(-)-menthone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.81] xref: EC:1.3.1.81 xref: MetaCyc:RXN-5164 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2010-08-09T04:33:53Z [Term] id: GO:0052581 name: (-)-isopiperitenone reductase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+)." [EC:1.3.1.82, RHEA:25651] synonym: "(+)-cis-isopulegone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.82] xref: EC:1.3.1.82 xref: KEGG_REACTION:R06417 xref: MetaCyc:RXN-5161 xref: RHEA:25651 is_a: GO:0035671 ! enone reductase activity created_by: gwg creation_date: 2010-08-09T04:42:05Z [Term] id: GO:0052582 name: (+)-menthofuran synthase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+)." [EC:1.14.14.143, RHEA:25658] synonym: "(+)-MFS activity" BROAD [EC:1.14.13.104] synonym: "(+)-pulegone 9-hydroxylase activity" EXACT [EC:1.14.14.143] synonym: "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity" EXACT [EC:1.14.14.143] synonym: "cytochrome P450 menthofuran synthase activity" EXACT [EC:1.14.14.143] synonym: "menthofuran synthase activity" EXACT [EC:1.14.14.143] xref: EC:1.14.14.143 xref: KEGG_REACTION:R08923 xref: MetaCyc:1.14.13.104-RXN xref: RHEA:25658 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: gwg creation_date: 2010-08-09T04:47:42Z [Term] id: GO:0052583 name: oxidoreductase activity, acting on halogen in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] xref: EC:1.22 is_a: GO:0016491 ! oxidoreductase activity creation_date: 2010-08-13T10:14:12Z [Term] id: GO:0052584 name: oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:mah] xref: EC:1.22.1 is_a: GO:0052583 ! oxidoreductase activity, acting on halogen in donors created_by: gwg creation_date: 2010-08-13T10:17:56Z [Term] id: GO:0052585 name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:ai] xref: EC:1.4.5 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors creation_date: 2010-08-13T10:29:06Z [Term] id: GO:0052586 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:jl] xref: EC:1.7.5 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors created_by: gwg creation_date: 2010-08-13T10:34:37Z [Term] id: GO:0052587 name: diacetyl reductase ((R)-acetoin forming) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.303, RHEA:22900] synonym: "(R)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.303] xref: EC:1.1.1.303 xref: KEGG_REACTION:R02855 xref: MetaCyc:RXN-11036 xref: RHEA:22900 is_a: GO:0019152 ! acetoin dehydrogenase activity [Term] id: GO:0052588 name: diacetyl reductase ((S)-acetoin forming) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.304, RHEA:27286] synonym: "(S)-acetoin dehydrogenase activity" EXACT [EC:1.1.1.304] xref: EC:1.1.1.304 xref: KEGG_REACTION:R09078 xref: MetaCyc:RXN-11032 xref: RHEA:27286 is_a: GO:0019152 ! acetoin dehydrogenase activity [Term] id: GO:0052589 name: malate dehydrogenase (menaquinone) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol." [MetaCyc:RXNI-3] synonym: "(S)-malate:(menaquinone) oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "(S)-malate:menaquinone oxidoreductase activity" EXACT [EC:1.1.5.4] xref: EC:1.1.5.4 xref: MetaCyc:RXNI-3 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0052590 name: sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol." [MetaCyc:RXN0-5258] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. xref: EC:1.1.5.3 xref: MetaCyc:RXN0-5258 is_a: GO:0004368 ! glycerol-3-phosphate dehydrogenase (quinone) activity [Term] id: GO:0052591 name: sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. xref: EC:1.1.5.3 xref: MetaCyc:GLYC3PDEHYDROG-RXN is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [Term] id: GO:0052592 name: oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] synonym: "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor" EXACT [] xref: EC:1.17.7 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0052593 name: tryptamine:oxygen oxidoreductase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+." [MetaCyc:RXN-1401] xref: EC:1.4.3.21 xref: KEGG_REACTION:R02173 xref: MetaCyc:RXN-1401 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052594 name: aminoacetone:oxygen oxidoreductase(deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." [MetaCyc:AMACETOXID-RXN] xref: EC:1.4.3.21 xref: KEGG_REACTION:R02529 xref: MetaCyc:AMACETOXID-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052595 name: aliphatic-amine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEOXID-RXN] synonym: "aliphatic-amine:oxygen oxidoreductase(deaminating) activity" EXACT [] xref: EC:1.4.3.21 xref: MetaCyc:AMINEOXID-RXN xref: RHEA:16153 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052596 name: phenethylamine:oxygen oxidoreductase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEPHEN-RXN] xref: EC:1.4.3.21 xref: KEGG_REACTION:R02613 xref: MetaCyc:AMINEPHEN-RXN xref: RHEA:25265 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052597 name: diamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide." [MetaCyc:RXN-9599] synonym: "diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: MetaCyc:RXN-9599 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052598 name: histamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-9600] synonym: "1H-Imidazole-4-ethanamine oxidase activity" EXACT [KEGG_REACTION:R02150] synonym: "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity" EXACT [KEGG_REACTION:R02150] synonym: "histamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: KEGG_REACTION:R02150 xref: MetaCyc:RXN-9600 xref: Reactome:R-HSA-5696131 "AOC1 deaminates Hist" xref: RHEA:25625 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052599 name: methylputrescine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-8244] synonym: "N-methylputrescine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] xref: EC:1.4.3.22 xref: KEGG_REACTION:R05334 xref: MetaCyc:RXN-8244 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052600 name: propane-1,3-diamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-6381] synonym: "1,3-diaminopropane oxidase activity" EXACT [KEGG:C00986] synonym: "propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725] xref: EC:1.4.3.22 xref: KEGG_REACTION:R03139 xref: MetaCyc:RXN-6381 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0052601 name: (S)-limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide." [MetaCyc:RXN-9409] synonym: "(-)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107] synonym: "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.107] synonym: "(S)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] xref: EC:1.14.13.107 xref: KEGG_REACTION:R09385 "(S)-limonene,NADH:oxygen oxidoreductase" xref: KEGG_REACTION:R09389 "(S)-limonene,NADPH:oxygen oxidoreductase" xref: MetaCyc:RXN-9409 xref: RHEA:26085 xref: RHEA:26089 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0052602 name: 4-chloronitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O." [MetaCyc:RXN-8833] xref: MetaCyc:RXN-8833 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0052603 name: 1-chloro-4-nitrosobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O." [MetaCyc:RXN-8834] xref: MetaCyc:RXN-8834 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0052604 name: delta-tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958] xref: KEGG_REACTION:R07503 xref: MetaCyc:RXN-2561 is_a: GO:0009975 ! cyclase activity [Term] id: GO:0052605 name: gamma-tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958] xref: KEGG_REACTION:R07502 xref: MetaCyc:RXN-2543 is_a: GO:0009975 ! cyclase activity [Term] id: GO:0052606 name: chlorophyllide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O." [EC:1.13.12.14, MetaCyc:RXN-7676] synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll a oxygenase activity" EXACT [] synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] xref: KEGG_REACTION:R08203 xref: MetaCyc:RXN-7676 xref: RHEA:22676 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity [Term] id: GO:0052607 name: 7-hydroxy-chlorophyllide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O." [EC:1.13.12.14, MetaCyc:RXN-7677] synonym: "7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "7-hydroxychlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll b synthetase activity" EXACT [] synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14] xref: KEGG_REACTION:R08204 xref: MetaCyc:RXN-7677 xref: RHEA:22136 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity [Term] id: GO:0052608 name: echinenone 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8214] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8214 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052609 name: 4-ketotorulene 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8218] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8218 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052610 name: beta-cryptoxanthin hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8026] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8026 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052611 name: beta-carotene 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8025] synonym: "beta-carotene 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8025 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052612 name: adonirubin 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8187] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8187 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052613 name: canthaxanthin 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8186] synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8186 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052614 name: uracil oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551] synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444] xref: MetaCyc:RXN0-6444 is_a: GO:0016491 ! oxidoreductase activity creation_date: 2010-08-26T10:11:11Z [Term] id: GO:0052615 name: ent-kaurene oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol." [MetaCyc:1.14.13.78-RXN] xref: EC:1.14.14.86 xref: MetaCyc:1.14.13.78-RXN xref: RHEA:32323 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052616 name: ent-kaur-16-en-19-ol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242] xref: EC:1.14.14.86 xref: MetaCyc:RXN-5242 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052617 name: ent-kaur-16-en-19-al oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580] xref: EC:1.14.14.86 xref: MetaCyc:RXN-7580 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052618 name: coenzyme F420-0:L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate." [MetaCyc:RXN-8080] xref: EC:6.3.2.31 xref: MetaCyc:RXN-8080 xref: RHEA:30555 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052619 name: coenzyme F420-1:gamma-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate." [MetaCyc:RXN-8081] xref: EC:6.3.2.34 xref: MetaCyc:RXN-8081 xref: RHEA:30523 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052620 name: thymine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [MetaCyc:RXN-8646] xref: EC:1.17.99.4 xref: MetaCyc:RXN-8646 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0052621 name: diguanylate cyclase activity namespace: molecular_function alt_id: GO:0043789 def: "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+)." [EC:2.7.7.65, RHEA:24898] synonym: "GTP:GTP guanylyltransferase activity" BROAD [EC:2.7.7.65] xref: EC:2.7.7.65 xref: KEGG_REACTION:R08057 xref: MetaCyc:RXN0-5359 xref: RHEA:24898 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0052622 name: ATP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate." [EC:2.5.1.27, MetaCyc:RXN-4303] synonym: "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R08052] synonym: "ATP isopentenyltransferase activity" EXACT [] synonym: "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] xref: EC:2.5.1 xref: KEGG_REACTION:R08052 xref: MetaCyc:RXN-4303 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: gwg creation_date: 2010-08-26T10:45:38Z [Term] id: GO:0052623 name: ADP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate." [EC:2.5.1.27, MetaCyc:RXN-4305] synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R08051] synonym: "ADP isopentenyltransferase activity" EXACT [] synonym: "dimethylallyl-diphosphate:ADP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] xref: EC:2.5.1 xref: KEGG_REACTION:R08051 xref: MetaCyc:RXN-4305 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: gwg creation_date: 2010-08-26T10:45:44Z [Term] id: GO:0052624 name: 2-phytyl-1,4-naphthoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+." [MetaCyc:RXN-6723, MetaCyc:RXN-7569, PMID:14617060] synonym: "demethylphylloquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity" EXACT [] synonym: "SA methyltransferase activity" BROAD [] synonym: "salicylate methyltransferase activity" BROAD [] synonym: "salicylic acid methyltransferase activity" BROAD [] xref: KEGG_REACTION:R06859 xref: MetaCyc:RXN-6723 xref: MetaCyc:RXN-7569 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008171 ! O-methyltransferase activity created_by: gwg creation_date: 2010-08-26T12:00:06Z [Term] id: GO:0052625 name: 4-aminobenzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] synonym: "4-aminobenzoyl amino acid synthetase activity" EXACT [] synonym: "p-aminobenzoate amino acid synthetase activity" EXACT [] synonym: "p-aminobenzoyl amino acid synthetase activity" EXACT [] synonym: "pABA amino acid synthetase activity" EXACT [] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052626 name: benzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10886, PMID:19189963] synonym: "benzoyl amino acid synthetase activity" EXACT [] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052627 name: vanillate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10885, PMID:19189963] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052628 name: 4-hydroxybenzoate amino acid synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] synonym: "4-hydroxybenzoyl amino acid synthetase activity" EXACT [] synonym: "4HBA amino acid synthetase activity" EXACT [] synonym: "p-hydroxybenzoate amino acid synthetase activity" EXACT [] synonym: "p-hydroxybenzoyl amino acid synthetase activity" EXACT [] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0052629 name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [MetaCyc:RXN-10958, PMID:19901554] xref: EC:3.1.3 xref: MetaCyc:RXN-10958 xref: Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane" xref: Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane" xref: Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane" xref: Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane" xref: Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1" xref: Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane" is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity [Term] id: GO:0052630 name: UDP-N-acetylgalactosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine." [EC:2.7.7.23] synonym: "N-acetylgalactosamine 1-phosphate uridylyltransferase" EXACT [] synonym: "N-acetylgalactosamine-1-phosphate uridyltransferase activity" EXACT [] synonym: "UDP-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "UDP-GalNAc pyrophosphorylase activity" EXACT [] synonym: "UDP-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphoacetylgalactosamine phosphorylase activity" EXACT [] synonym: "uridine diphosphoacetylgalactosamine pyrophosphorylase activity" EXACT [] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [] synonym: "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity" EXACT [] xref: EC:2.7.7 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0052631 name: sphingolipid delta-8 desaturase activity namespace: molecular_function def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850] xref: MetaCyc:RXN-7798 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0052633 name: isocitrate hydro-lyase (cis-aconitate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw, MetaCyc:ACONITATEHYDR-RXN] synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3] xref: KEGG_REACTION:R01900 xref: MetaCyc:ACONITATEHYDR-RXN xref: RHEA:22144 is_a: GO:0016836 ! hydro-lyase activity relationship: has_part GO:0003994 ! aconitate hydratase activity [Term] id: GO:0052634 name: C-19 gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons." [EC:1.14.11.13, GOC:kad] synonym: "(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] synonym: "C(19) gibberellin 2-oxidase activity" EXACT [] synonym: "C-19 GA 2-oxidase activity" EXACT [] synonym: "C-19 gibberellin 2-beta-hydroxylase activity" EXACT [] synonym: "C-19 gibberellin 2-oxidase activity" EXACT [] synonym: "C-19 gibberellin 2beta-dioxygenase activity" EXACT [] synonym: "C-19 gibberellin 2beta-hydroxylase activity" EXACT [] xref: EC:1.14.11 is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity [Term] id: GO:0052635 name: C-20 gibberellin 2-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons." [EC:1.14.11.13, GOC:kad] synonym: "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] synonym: "C(20) gibberellin 2-oxidase activity" EXACT [] synonym: "C-20 GA 2-oxidase activity" EXACT [] synonym: "C-20 gibberellin 2-beta-hydroxylase activity" EXACT [] synonym: "C-20 gibberellin 2-oxidase activity" EXACT [] synonym: "C-20 gibberellin 2beta-dioxygenase activity" EXACT [] synonym: "C-20 gibberellin 2beta-hydroxylase activity" EXACT [] xref: EC:1.14.11 is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity [Term] id: GO:0052636 name: arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)." [GOC:ai] synonym: "arabinosyl transferase activity" EXACT [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0052637 name: delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol." [GOC:ai, MetaCyc:RXN-8319, PMID:19682287] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0052638 name: indole-3-butyrate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655] synonym: "IBA-Glc synthetase activity" EXACT [] synonym: "IBA-glucose synthase activity" EXACT [] synonym: "IBAGlu synthase activity" EXACT [] synonym: "indol-3-ylbutyrylglucose synthase activity" EXACT [] synonym: "indole-3-butyric acid glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity" EXACT [] synonym: "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity" EXACT [] synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT [] synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT [] synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT [] xref: EC:2.4.1 xref: MetaCyc:RXN-11655 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052639 name: salicylic acid glucosyltransferase (ester-forming) activity namespace: molecular_function def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] xref: MetaCyc:RXN-11659 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052640 name: salicylic acid glucosyltransferase (glucoside-forming) activity namespace: molecular_function def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] xref: MetaCyc:RXN-11658 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052641 name: benzoic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP." [MetaCyc:RXN-11660] synonym: "benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:BA glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] synonym: "UDP:glucose:benzoic acid glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] xref: EC:2.4.1 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052642 name: lysophosphatidic acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [PMID:20045079, PMID:7966317] synonym: "LPA phosphatase activity" EXACT [] synonym: "lysophosphatidate phosphatase activity" EXACT [] xref: Reactome:R-HSA-8878654 "ACP6 hydrolyses MYS-LPA" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0052643 name: chlorophyllide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl." [PMID:7724548] synonym: "chlorophyllide metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0052644 name: chlorophyllide a metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a." [PMID:7724548] synonym: "chlorophyllide a metabolism" EXACT [] is_a: GO:0052643 ! chlorophyllide metabolic process [Term] id: GO:0052645 name: F420-0 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues." [CHEBI:59532] synonym: "coenzyme F420-0 metabolic process" EXACT [CHEBI:59532] synonym: "coenzyme F420-0 metabolism" EXACT [CHEBI:59532] synonym: "F(420)-0 metabolic process" EXACT [CHEBI:59532] synonym: "F420-0 metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0052648 ! ribitol phosphate metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: gwg creation_date: 2010-09-22T04:11:38Z [Term] id: GO:0052646 name: alditol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [PMID:30240188] synonym: "alditol phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: gwg creation_date: 2010-09-22T04:24:21Z [Term] id: GO:0052647 name: pentitol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule." [CHEBI:25898, ISBN:0198506732] synonym: "pentitol phosphate metabolism" EXACT [] is_a: GO:0052646 ! alditol phosphate metabolic process created_by: gwg creation_date: 2010-09-22T04:26:28Z [Term] id: GO:0052648 name: ribitol phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [CHEBI:26554, ISBN:0198506732] synonym: "ribitol phosphate metabolism" EXACT [] is_a: GO:0052647 ! pentitol phosphate metabolic process created_by: gwg creation_date: 2010-09-22T04:28:37Z [Term] id: GO:0052649 name: coenzyme gamma-F420-2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid." [CHEBI:16848] synonym: "coenzyme F420 metabolic process" EXACT [CHEBI:16848] synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848] synonym: "coenzyme gamma-F420-2 metabolism" EXACT [] synonym: "F420-2 metabolic process" EXACT [CHEBI:16848] synonym: "F420-2 metabolism" EXACT [CHEBI:16848] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0052648 ! ribitol phosphate metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: gwg creation_date: 2010-09-22T04:32:35Z [Term] id: GO:0052650 name: NADP-retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033] synonym: "all-trans retinal reductase activity" BROAD [EC:1.1.1.300] synonym: "all-trans-retinol dehydrogenase activity" BROAD [EC:1.1.1.300] synonym: "NADP(H)-dependent retinol dehydrogenase/reductase activity" EXACT [EC:1.1.1.300] synonym: "retinol dehydrogenase [NADP+] activity" EXACT [EC:1.1.1.300] synonym: "retinol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.300] xref: EC:1.1.1.300 xref: KEGG_REACTION:R08379 xref: MetaCyc:RXN-10841 xref: Reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL" xref: Reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL" xref: Reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL" xref: Reactome:R-HSA-2465940 "atRAL is reduced to atROL" xref: Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL and causes LCA13" xref: Reactome:R-HSA-2471670 "Defective RDH12 does not reduce atRAL to atROL" xref: Reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL" xref: Reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL" xref: Reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL" xref: Reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL" xref: RHEA:25033 is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0052651 name: monoacylglycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [http://cancerweb.ncl.ac.uk/] synonym: "monoacylglycerol breakdown" EXACT [] synonym: "monoacylglycerol catabolism" EXACT [] synonym: "monoacylglycerol degradation" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046464 ! acylglycerol catabolic process creation_date: 2010-09-23T09:26:36Z [Term] id: GO:0052652 name: cyclic purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [PMID:23911318] synonym: "cyclic purine nucleotide metabolism" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process creation_date: 2010-09-23T11:15:59Z [Term] id: GO:0052653 name: 3',5'-cyclic diguanylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine." [CHEBI:593038] synonym: "3',5'-cyclic diguanylic acid metabolism" EXACT [] synonym: "cdiGMP metabolic process" EXACT [] synonym: "cdiGMP metabolism" EXACT [] synonym: "cyclic diguanylate metabolic process" EXACT [] synonym: "cyclic diguanylate metabolism" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process created_by: gwg creation_date: 2010-09-23T11:16:56Z [Term] id: GO:0052654 name: L-leucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN] subset: goslim_chembl synonym: "L-leucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG_REACTION:R01090 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052655 name: L-valine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN] subset: goslim_chembl synonym: "L-valine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG_REACTION:R01214 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052656 name: L-isoleucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN] subset: goslim_chembl synonym: "L-isoleucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG_REACTION:R02199 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] id: GO:0052657 name: guanine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "GPRT" RELATED [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG_REACTION:R01229 xref: MetaCyc:GUANPRIBOSYLTRAN-RXN is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0052658 name: inositol-1,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19797] synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" BROAD [] synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3) 5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "InsP3 5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] xref: EC:3.1.3.56 xref: KEGG_REACTION:R03394 xref: MetaCyc:3.1.3.56-RXN xref: Reactome:R-HSA-1855174 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol" xref: Reactome:R-HSA-1855222 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane" xref: RHEA:19797 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0052659 name: inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11392] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] synonym: "Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] xref: EC:3.1.3.56 xref: KEGG_REACTION:R03430 xref: MetaCyc:RXN-8730 xref: Reactome:R-HSA-1855213 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane" xref: Reactome:R-HSA-1855218 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol" xref: RHEA:11392 is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity [Term] id: GO:0052660 name: R-lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+." [RHEA:23872] synonym: "(R)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "D-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] xref: KEGG_REACTION:R03080 xref: MetaCyc:RXN-8641 xref: RHEA:23872 is_a: GO:0008912 ! lactaldehyde reductase activity [Term] id: GO:0052661 name: S-lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+." [RHEA:15933] synonym: "(S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] xref: KEGG_REACTION:R02258 xref: MetaCyc:LACTALDREDUCT-RXN xref: RHEA:15933 is_a: GO:0008912 ! lactaldehyde reductase activity [Term] id: GO:0052662 name: zeaxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: KEGG_REACTION:R06946 "zeaxanthin,NADH:oxygen oxidoreductase activity" xref: KEGG_REACTION:R07199 "zeaxanthin,NADPH:oxygen oxidoreductase activity" xref: MetaCyc:RXN-7978 xref: RHEA:24084 xref: RHEA:24091 "zeaxanthin,NADH:oxygen oxidoreductase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052663 name: antheraxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979] synonym: "antheraxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: KEGG_REACTION:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity" xref: KEGG_REACTION:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity" xref: MetaCyc:RXN-7979 xref: RHEA:14937 xref: RHEA:14944 "antheraxanthin,NADH:oxygen oxidoreductase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052664 name: nitroalkane oxidase activity namespace: molecular_function def: "Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2." [EC:1.7.3.1] synonym: "NAO activity" EXACT [EC:1.7.3.1] synonym: "nitroalkane reductase activity" EXACT [EC:1.7.3.1] synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] xref: EC:1.7.3.1 xref: KEGG_REACTION:R00799 xref: MetaCyc:RXN-11045 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor creation_date: 2010-10-11T10:50:59Z [Term] id: GO:0052665 name: tRNA (uracil-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil." [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (uracil 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA uracil 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA uracil-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: MetaCyc:RXN0-5143 xref: Reactome:R-HSA-6788707 "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)" is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity created_by: gwg creation_date: 2010-10-11T01:05:35Z [Term] id: GO:0052666 name: tRNA (cytosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine." [GOC:hjd] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity" EXACT [] synonym: "transfer ribonucleate cytosine 2'-methyltransferase activity" EXACT [] synonym: "tRNA (cytosine 2')-methyltransferase activity" EXACT [] synonym: "tRNA cytosine 2'-methyltransferase activity" EXACT [] synonym: "tRNA cytosine-2'-O-methyltransferase activity" EXACT [] xref: MetaCyc:RXN0-5143 xref: Reactome:R-HSA-6788668 "TRMT13 2'-O-methylates adenosine-4 in tRNA" xref: Reactome:R-HSA-6788684 "TRMT13 2'-O-methylates cytidine-4 in tRNA" xref: Reactome:R-HSA-9024159 "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)" is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity created_by: gwg creation_date: 2010-10-11T01:05:47Z [Term] id: GO:0052667 name: phosphomethylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)." [KEGG_REACTION:R06868, MetaCyc:RXN-5642, RHEA:25322] synonym: "N-methylethanolamine phosphate N-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity" EXACT systematic_synonym [KEGG_REACTION:R06868] xref: KEGG_REACTION:R06868 xref: MetaCyc:RXN-5642 xref: RHEA:25322 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: gwg creation_date: 2011-04-11T11:36:47Z [Term] id: GO:0052668 name: farnesol kinase activity namespace: molecular_function def: "Catalysis of the reaction: farnesol + nucleoside triphosphate = farnesyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11625] synonym: "farnesol phosphotransferase activity" EXACT [] synonym: "trans,trans-farnesol kinase activity" NARROW [] xref: EC:2.7.1.216 is_a: GO:0052673 ! prenol kinase activity created_by: gwg creation_date: 2011-04-11T01:19:25Z [Term] id: GO:0052669 name: CTP:2-trans,-6-trans-farnesol kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+." [MetaCyc:RXN-11625] synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT [] xref: EC:2.7.1.216 xref: MetaCyc:RXN-11625 is_a: GO:0052668 ! farnesol kinase activity created_by: gwg creation_date: 2011-04-11T01:32:05Z [Term] id: GO:0052670 name: geraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate." [GOC:kd] synonym: "geraniol phosphotransferase activity" EXACT [] is_a: GO:0052673 ! prenol kinase activity created_by: gwg creation_date: 2011-04-11T03:14:02Z [Term] id: GO:0052671 name: geranylgeraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11629] synonym: "geranylgeraniol phosphotransferase activity" EXACT [] xref: EC:2.7.1.B19 is_a: GO:0052673 ! prenol kinase activity created_by: gwg creation_date: 2011-04-11T03:18:44Z [Term] id: GO:0052672 name: CTP:geranylgeraniol kinase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP." [MetaCyc:RXN-11629] synonym: "CTP:geranylgeraniol phosphotransferase activity" EXACT [] xref: EC:2.7.1.216 xref: MetaCyc:RXN-11629 is_a: GO:0052671 ! geranylgeraniol kinase activity created_by: gwg creation_date: 2011-04-11T03:26:04Z [Term] id: GO:0052673 name: prenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity." [GOC:ai, GOC:kd] synonym: "prenol phosphotransferase activity" EXACT [] synonym: "prenyl alcohol kinase activity" EXACT [] synonym: "prenyl alcohol phosphotransferase activity" EXACT [] is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: gwg creation_date: 2011-04-11T04:02:23Z [Term] id: GO:0052674 name: ent-pimara-9(11),15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate." [RHEA:25544] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.31] synonym: "PMD synthase activity" BROAD [EC:4.2.3.31] xref: EC:4.2.3.31 xref: MetaCyc:RXN-9299 xref: RHEA:25544 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052675 name: 3-methylbutanol:NADP oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG_REACTION:R05686] synonym: "3-methylbutanal reductase (NADP) activity" EXACT [] synonym: "3-methylbutanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase (NADP) activity" EXACT [] synonym: "isoamyl alcohol oxidase (NADP) activity" EXACT [] xref: KEGG_REACTION:R05686 xref: RHEA:18525 is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity created_by: gwg creation_date: 2011-04-12T11:19:27Z [Term] id: GO:0052676 name: 3-methylbutanol:NAD oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG_REACTION:R05685] synonym: "3-methylbutanal reductase (NAD) activity" EXACT [] synonym: "3-methylbutanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.265] synonym: "3-methylbutyraldehyde reductase (NAD) activity" EXACT [] synonym: "isoamyl alcohol oxidase (NAD) activity" EXACT [] xref: KEGG_REACTION:R05685 xref: RHEA:18529 is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity created_by: gwg creation_date: 2011-04-12T11:22:42Z [Term] id: GO:0052677 name: D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+." [EC:1.1.1.287] synonym: "ARD1p" RELATED [EC:1.1.1.287] synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] xref: KEGG_REACTION:R07143 xref: MetaCyc:RXN-7971 xref: RHEA:21276 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2011-04-12T02:33:43Z [Term] id: GO:0052678 name: levopimaradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate." [RHEA:25548] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.32] xref: EC:4.2.3.32 xref: KEGG_REACTION:R06302 xref: MetaCyc:4.2.3.32-RXN xref: RHEA:25548 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052679 name: terpentetriene synthase activity namespace: molecular_function def: "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene." [RHEA:25617] synonym: "terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity" EXACT systematic_synonym [EC:4.2.3.36] xref: EC:4.2.3.36 xref: MetaCyc:RXN-9455 xref: RHEA:25617 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052680 name: epi-isozizaene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate." [RHEA:25992] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity" EXACT systematic_synonym [EC:4.2.3.37, KEGG_REACTION:R07830] xref: EC:4.2.3.37 xref: KEGG_REACTION:R07830 xref: MetaCyc:RXN-9349 xref: RHEA:25992 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052681 name: alpha-bisabolene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate." [RHEA:25436] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.38] synonym: "bisabolene synthase activity" BROAD [KEGG_REACTION:R08370] xref: EC:4.2.3.38 xref: KEGG_REACTION:R08370 xref: MetaCyc:RXN-8550 xref: RHEA:25436 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052682 name: epi-cedrol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate." [RHEA:26115] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity" EXACT systematic_synonym [EC:4.2.3.39] synonym: "8-epicedrol synthase activity" EXACT [] synonym: "epicedrol synthase activity" EXACT [] xref: EC:4.2.3.39 xref: KEGG_REACTION:R09140 xref: MetaCyc:RXN-10004 xref: RHEA:26115 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052683 name: (Z)-gamma-bisabolene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate." [RHEA:26081] synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.40] xref: EC:4.2.3.40 xref: MetaCyc:RXN-10005 xref: RHEA:26081 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0052684 name: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity namespace: molecular_function def: "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O." [MetaCyc:RXN0-2382] synonym: "L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity" EXACT [GOC:bf] synonym: "tryptophan synthase beta subunit activity" NARROW [] xref: EC:4.2.1.122 xref: KEGG_REACTION:R00674 xref: MetaCyc:RXN0-2382 xref: RHEA:26434 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0052685 name: perillic acid:CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA." [KEGG_REACTION:R06368] synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] xref: EC:6.2.1 xref: KEGG_REACTION:R06367 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052686 name: perillic acid:CoA ligase (AMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA." [KEGG_REACTION:R06368] synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] xref: KEGG_REACTION:R06368 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052687 name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06396] synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] xref: KEGG_REACTION:R06396 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052688 name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06515] synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] xref: KEGG_REACTION:R06515 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0052689 name: carboxylic ester hydrolase activity namespace: molecular_function alt_id: GO:0004091 alt_id: GO:0004302 alt_id: GO:0004759 alt_id: GO:0016789 def: "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1, EC:3.1.1.1, GOC:curators] subset: goslim_drosophila synonym: "ali-esterase activity" NARROW [EC:3.1.1.1] synonym: "alpha-carboxylesterase activity" NARROW [EC:3.1.1.1] synonym: "B-esterase activity" RELATED [EC:3.1.1.1] synonym: "carboxyesterase activity" EXACT [EC:3.1.1.1] synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1.1] synonym: "carboxylate esterase activity" EXACT [EC:3.1.1.1] synonym: "carboxylesterase activity" EXACT [] synonym: "carboxylic acid esterase activity" EXACT [] synonym: "carboxylic ester hydrolase activity" RELATED [] synonym: "carboxylic esterase activity" EXACT [EC:3.1.1.1] synonym: "cocaine esterase activity" NARROW [EC:3.1.1.1] synonym: "esterase A" NARROW [EC:3.1.1.1] synonym: "esterase B" NARROW [EC:3.1.1.1] synonym: "nonspecific carboxylesterase activity" RELATED [EC:3.1.1.1] synonym: "procaine esterase activity" NARROW [EC:3.1.1.1] synonym: "serine esterase activity" NARROW [] synonym: "triacetin esterase" NARROW [EC:3.1.1.1] synonym: "vitamin A esterase" NARROW [EC:3.1.1.1] xref: EC:3.1.1 xref: EC:3.1.1.1 xref: KEGG_REACTION:R00630 xref: MetaCyc:CARBOXYLESTERASE-RXN xref: Reactome:R-HSA-5693691 "CES1 trimer.CES2 hydrolyse COCN to BEG" xref: Reactome:R-HSA-8937442 "CES3 hydrolyses CHEST to CHOL and LCFA(-)" xref: Reactome:R-HSA-9619024 "CES1trimer hydrolyses ACEI pro-drugs to ACEIs" xref: UM-BBD_reactionID:r1025 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0052690 name: trichloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0031, UM-BBD_reactionID:r0315] synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251] synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT [] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] xref: EC:1.6.99.1 xref: EC:1.8.99 xref: UM-BBD_reactionID:r0031 xref: UM-BBD_reactionID:r0315 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0052691 name: UDP-arabinopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose." [EC:5.4.99.30, RHEA:28350] synonym: "UDP-arabinopyranose pyranomutase activity" EXACT systematic_synonym [EC:5.4.99.30] synonym: "UDP-L-Ara mutase activity" EXACT [EC:5.4.99.30] synonym: "UDP-L-arabinopyranose furanomutase activity" EXACT [EC:5.4.99.30] synonym: "UDP-L-arabinose mutase activity" EXACT [EC:5.4.99.30] synonym: "uridine-diphosphate-L-arabinose mutase activity" EXACT [EC:5.4.99.30] xref: EC:5.4.99.30 xref: MetaCyc:RXN-11552 xref: RHEA:28350 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0052692 name: raffinose alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [MetaCyc:RXN-11502] synonym: "alkaline alpha-galactosidase activity" BROAD [] synonym: "raffinose galactohydrolase activity" BROAD [] synonym: "raffinose-specific alkaline alpha-galactosidase activity" EXACT [PMID:20739305] xref: EC:3.2.1.22 xref: KEGG_REACTION:R01103 xref: MetaCyc:RXN-11502 is_a: GO:0004557 ! alpha-galactosidase activity [Term] id: GO:0052693 name: epoxyqueuosine reductase activity namespace: molecular_function def: "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant." [PMID:21502530] xref: EC:1.17.99.6 {comment="PMID:21502530"} xref: RHEA:32159 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0052694 name: jasmonoyl-isoleucine-12-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464] xref: MetaCyc:RXN-12421 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0052695 name: cellular glucuronidation namespace: biological_process def: "The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor." [GOC:BHF] synonym: "cellular glucuronide biosynthesis" EXACT [] synonym: "cellular glucuronide biosynthetic process" EXACT [] synonym: "cellular glucuronoside biosynthesis" EXACT [] synonym: "cellular glucuronoside biosynthetic process" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process creation_date: 2011-07-27T05:28:18Z [Term] id: GO:0052696 name: flavonoid glucuronidation namespace: biological_process def: "The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor." [GOC:BHF, PMID:20056724] synonym: "flavonoid glucuronide biosynthesis" EXACT [] synonym: "flavonoid glucuronide biosynthetic process" EXACT [] synonym: "flavonoid glucuronoside biosynthesis" EXACT [] synonym: "flavonoid glucuronoside biosynthetic process" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:0052695 ! cellular glucuronidation created_by: gwg creation_date: 2011-07-27T05:37:44Z [Term] id: GO:0052697 name: xenobiotic glucuronidation namespace: biological_process def: "The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion." [GOC:BHF, PMID:20056724] synonym: "phase II metabolism" NARROW [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0052695 ! cellular glucuronidation created_by: gwg creation_date: 2011-07-27T05:37:50Z [Term] id: GO:0052698 name: ergothioneine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine metabolic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine metabolism" EXACT [CHEBI:4828] synonym: "ergothioneine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: gwg creation_date: 2011-08-01T03:52:11Z [Term] id: GO:0052699 name: ergothioneine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine anabolism" EXACT [] synonym: "2-mercaptoergothioneine trimethylbetaine biosynthesis" EXACT [] synonym: "2-mercaptoergothioneine trimethylbetaine biosynthetic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine formation" EXACT [] synonym: "2-mercaptoergothioneine trimethylbetaine synthesis" EXACT [] synonym: "ergothioneine anabolism" EXACT [] synonym: "ergothioneine biosynthesis" EXACT [] synonym: "ergothioneine formation" EXACT [] synonym: "ergothioneine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0052698 ! ergothioneine metabolic process is_a: GO:0052703 ! cellular modified histidine biosynthetic process created_by: gwg creation_date: 2011-08-01T03:56:19Z [Term] id: GO:0052700 name: ergothioneine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine breakdown" EXACT [] synonym: "2-mercaptoergothioneine trimethylbetaine catabolic process" EXACT [CHEBI:4828] synonym: "2-mercaptoergothioneine trimethylbetaine catabolism" EXACT [] synonym: "2-mercaptoergothioneine trimethylbetaine degradation" EXACT [] synonym: "ergothioneine breakdown" EXACT [] synonym: "ergothioneine catabolism" EXACT [] synonym: "ergothioneine degradation" EXACT [] is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0052698 ! ergothioneine metabolic process is_a: GO:0052702 ! cellular modified histidine catabolic process created_by: gwg creation_date: 2011-08-01T03:56:22Z [Term] id: GO:0052701 name: cellular modified histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] synonym: "cellular histidine derivative metabolic process" EXACT [] synonym: "cellular histidine derivative metabolism" EXACT [] synonym: "cellular modified histidine metabolism" EXACT [] synonym: "histidine derivative metabolic process" EXACT [] synonym: "modified histidine metabolic process" EXACT [] synonym: "modified histidine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process creation_date: 2011-08-01T03:47:00Z [Term] id: GO:0052702 name: cellular modified histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] synonym: "cellular histidine derivative breakdown" EXACT [] synonym: "cellular histidine derivative catabolic process" EXACT [] synonym: "cellular histidine derivative catabolism" EXACT [] synonym: "cellular histidine derivative degradation" EXACT [] synonym: "cellular modified histidine breakdown" EXACT [] synonym: "cellular modified histidine catabolism" EXACT [] synonym: "cellular modified histidine degradation" EXACT [] synonym: "histidine derivative catabolic process" EXACT [] synonym: "modified histidine catabolic process" EXACT [] synonym: "modified histidine catabolism" EXACT [] is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: gwg creation_date: 2011-08-01T03:48:41Z [Term] id: GO:0052703 name: cellular modified histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] synonym: "cellular histidine derivative anabolism" EXACT [] synonym: "cellular histidine derivative biosynthesis" EXACT [] synonym: "cellular histidine derivative biosynthetic process" EXACT [] synonym: "cellular histidine derivative formation" EXACT [] synonym: "cellular histidine derivative synthesis" EXACT [] synonym: "cellular modified histidine anabolism" EXACT [] synonym: "cellular modified histidine biosynthesis" EXACT [] synonym: "cellular modified histidine formation" EXACT [] synonym: "cellular modified histidine synthesis" EXACT [] synonym: "histidine derivative biosynthetic process" EXACT [] is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: gwg creation_date: 2011-08-01T03:49:39Z [Term] id: GO:0052704 name: ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine namespace: biological_process def: "The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine." [DOI:10.1021/ja101721e, EC:2.1.1.44, PMID:4276459, PMID:5484456, Wikipedia:Ergothioneine] is_a: GO:0006548 ! histidine catabolic process is_a: GO:0052699 ! ergothioneine biosynthetic process is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process relationship: has_part GO:0052707 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine relationship: has_part GO:0052711 ! ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine creation_date: 2011-08-05T11:31:52Z [Term] id: GO:0052705 name: methylhistidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine." [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] synonym: "methylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity" EXACT [EC:2.1.1.44] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: gwg creation_date: 2011-08-05T11:54:54Z [Term] id: GO:0052706 name: histidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44] synonym: "histidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: gwg creation_date: 2011-08-05T11:57:40Z [Term] id: GO:0052707 name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine namespace: biological_process def: "The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [EC:2.1.1.44] synonym: "hercynine biosynthesis from histidine" EXACT [] synonym: "histidine betaine biosynthesis from histidine" EXACT [] synonym: "histidine catabolic process to hercynine" EXACT [] synonym: "histidine catabolism to hercynine" EXACT [] synonym: "histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" EXACT [] xref: KEGG_REACTION:R01169 is_a: GO:0006548 ! histidine catabolic process is_a: GO:0052709 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process relationship: has_part GO:0030745 ! dimethylhistidine N-methyltransferase activity relationship: has_part GO:0052705 ! methylhistidine N-methyltransferase activity relationship: has_part GO:0052706 ! histidine N-methyltransferase activity created_by: gwg creation_date: 2011-08-05T02:07:24Z [Term] id: GO:0052708 name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575] synonym: "hercynine metabolic process" EXACT [CHEBI:15781] synonym: "hercynine metabolism" EXACT [CHEBI:15781] synonym: "histidine betaine metabolic process" EXACT [CHEBI:15781] synonym: "histidine betaine metabolism" EXACT [CHEBI:15781] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: gwg creation_date: 2011-08-05T02:13:31Z [Term] id: GO:0052709 name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575] synonym: "hercynine anabolism" EXACT [] synonym: "hercynine biosynthesis" EXACT [] synonym: "hercynine biosynthetic process" EXACT [] synonym: "hercynine formation" EXACT [] synonym: "hercynine synthesis" EXACT [] synonym: "histidine betaine anabolism" EXACT [] synonym: "histidine betaine biosynthesis" EXACT [] synonym: "histidine betaine biosynthetic process" EXACT [] synonym: "histidine betaine formation" EXACT [] synonym: "histidine betaine synthesis" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process created_by: gwg creation_date: 2011-08-05T02:22:05Z [Term] id: GO:0052710 name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [CHEBI:15781, KEGG:C05575] synonym: "hercynine breakdown" EXACT [] synonym: "hercynine catabolic process" EXACT [] synonym: "hercynine catabolism" EXACT [] synonym: "hercynine degradation" EXACT [] synonym: "histidine betaine breakdown" EXACT [] synonym: "histidine betaine catabolic process" EXACT [] synonym: "histidine betaine catabolism" EXACT [] synonym: "histidine betaine degradation" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation" EXACT [] is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process created_by: gwg creation_date: 2011-08-05T02:22:54Z [Term] id: GO:0052711 name: ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine namespace: biological_process def: "The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878] synonym: "ergothioneine biosynthesis from hercynine" EXACT [] synonym: "ergothioneine biosynthesis from histidine betaine" EXACT [] synonym: "hercynine catabolism to ergothioneine" EXACT [] synonym: "histidine betaine catabolism to ergothioneine" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT [] xref: KEGG_REACTION:R04878 is_a: GO:0052699 ! ergothioneine biosynthetic process is_a: GO:0052710 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process creation_date: 2011-08-05T04:06:16Z [Term] id: GO:0052712 name: inositol phosphosphingolipid phospholipase activity namespace: molecular_function def: "Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol." [GOC:ai] is_a: GO:0004629 ! phospholipase C activity created_by: gwg creation_date: 2011-08-05T04:49:13Z [Term] id: GO:0052713 name: inositol phosphorylceramide phospholipase activity namespace: molecular_function def: "Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol." [GOC:ai] is_a: GO:0052712 ! inositol phosphosphingolipid phospholipase activity created_by: gwg creation_date: 2011-08-05T04:51:03Z [Term] id: GO:0052714 name: mannosyl-inositol phosphorylceramide phospholipase activity namespace: molecular_function def: "Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol." [GOC:ai] is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity created_by: gwg creation_date: 2011-08-05T08:02:57Z [Term] id: GO:0052715 name: mannosyl-diinositol phosphorylceramide phospholipase activity namespace: molecular_function def: "Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol." [GOC:ai] is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity created_by: gwg creation_date: 2011-08-05T08:02:57Z [Term] id: GO:0052716 name: hydroquinone:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O." [EC:1.10.3.2] synonym: "benzenediol:oxygen oxidoreductase activity" BROAD [] synonym: "laccase reaction" BROAD [] synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT [] xref: EC:1.10.3.2 xref: KEGG_REACTION:R00083 xref: MetaCyc:LACCASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor created_by: gwg creation_date: 2011-08-11T03:18:19Z [Term] id: GO:0052717 name: tRNA-specific adenosine-34 deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641] synonym: "tRNA(Ala)-A34 deaminase activity" EXACT [] is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity created_by: gwg creation_date: 2011-08-12T11:48:54Z [Term] id: GO:0052718 name: tRNA-specific adenosine-34 deaminase complex namespace: cellular_component def: "A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human." [PMID:17875641] synonym: "tRNA-A34 deaminase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular created_by: gwg creation_date: 2011-08-12T11:53:26Z [Term] id: GO:0052719 name: apurinic/apyrimidinic endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends." [PMID:19401441] synonym: "abasic endoribonuclease activity" EXACT [] synonym: "AP endoribonuclease activity" EXACT [] synonym: "apurinic endoribonuclease activity" NARROW [] synonym: "apyrimidinic endoribonuclease activity" NARROW [] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0052720 name: class II DNA-(apurinic or apyrimidinic site) endonuclease activity namespace: molecular_function alt_id: GO:0140079 def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441] comment: Class II AP endonuclease is a nuclease, but not Class I, III and IV. See discussion at: \nhttps://github.com/geneontology/go-ontology/issues/13409 synonym: "class II DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters created_by: pg creation_date: 2017-07-24T11:46:03Z [Term] id: GO:0052721 name: regulation of apurinic/apyrimidinic endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441] synonym: "regulation of abasic endodeoxyribonuclease activity" EXACT [] synonym: "regulation of AP endodeoxyribonuclease activity" EXACT [] synonym: "regulation of apurinic endodeoxyribonuclease activity" NARROW [] synonym: "regulation of apyrimidinic endodeoxyribonuclease activity" NARROW [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity relationship: regulates GO:0052720 ! class II DNA-(apurinic or apyrimidinic site) endonuclease activity [Term] id: GO:0052722 name: fatty acid in-chain hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186] xref: MetaCyc:RXN-12186 is_a: GO:0004497 ! monooxygenase activity created_by: gwg creation_date: 2011-08-15T01:41:07Z [Term] id: GO:0052723 name: inositol hexakisphosphate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] xref: EC:2.7.4.21 xref: KEGG_REACTION:R05799 xref: MetaCyc:RXN-10972 is_a: GO:0000828 ! inositol hexakisphosphate kinase activity created_by: gwg creation_date: 2011-08-16T11:47:36Z [Term] id: GO:0052724 name: inositol hexakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] xref: EC:2.7.4.21 xref: MetaCyc:RXN-10971 is_a: GO:0000828 ! inositol hexakisphosphate kinase activity created_by: gwg creation_date: 2011-08-16T11:50:48Z [Term] id: GO:0052725 name: inositol-1,3,4-trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" BROAD [] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" EXACT [] synonym: "inositol-trisphosphate 6-kinase activity" BROAD [] synonym: "ins(1,3,4)P(3) 6-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,3,4)P3 6-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 6-kinase activity" BROAD [EC:2.7.1.127] xref: EC:2.7.1.159 xref: MetaCyc:2.7.1.133-RXN xref: Reactome:R-HSA-1855197 "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol" xref: Reactome:R-HSA-2267372 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4" is_a: GO:0051766 ! inositol trisphosphate kinase activity created_by: gwg creation_date: 2011-08-16T12:42:59Z [Term] id: GO:0052726 name: inositol-1,3,4-trisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" BROAD [] synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" EXACT [] synonym: "inositol-trisphosphate 5-kinase activity" BROAD [] synonym: "ins(1,3,4)P(3) 5-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,3,4)P3 5-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 5-kinase activity" BROAD [EC:2.7.1.127] xref: EC:2.7.1.159 xref: KEGG_REACTION:R03428 xref: MetaCyc:2.7.1.139-RXN xref: Reactome:R-HSA-1855172 "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol" xref: Reactome:R-HSA-994140 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4" is_a: GO:0051766 ! inositol trisphosphate kinase activity created_by: gwg creation_date: 2011-08-16T12:43:11Z [Term] id: GO:0052727 name: capsanthin synthase activity namespace: molecular_function def: "Catalysis of the reaction: antheraxanthin = capsanthin." [EC:5.3.99.8] synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8] synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] xref: EC:5.3.99.8 xref: MetaCyc:RXN-7947 is_a: GO:0016860 ! intramolecular oxidoreductase activity created_by: gwg creation_date: 2011-08-16T03:09:21Z [Term] id: GO:0052728 name: capsorubin synthase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin = capsorubin." [EC:5.3.99.8] synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8] synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8] xref: EC:5.3.99.8 xref: MetaCyc:RXN-7946 is_a: GO:0016860 ! intramolecular oxidoreductase activity created_by: gwg creation_date: 2011-08-16T03:09:26Z [Term] id: GO:0052729 name: dimethylglycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] synonym: "ApDMT" RELATED [EC:2.1.1.157] synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] xref: EC:2.1.1.157 xref: EC:2.1.1.161 xref: EC:2.1.1.162 xref: KEGG_REACTION:R07244 xref: MetaCyc:R482-RXN xref: MetaCyc:RXN-9680 xref: RHEA:10072 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: gwg creation_date: 2011-08-16T03:45:16Z [Term] id: GO:0052730 name: sarcosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.157] synonym: "S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.157] synonym: "SDMT" RELATED [EC:2.1.1.157] xref: EC:2.1.1.156 xref: EC:2.1.1.157 xref: EC:2.1.1.162 xref: KEGG_REACTION:R07243 xref: MetaCyc:R481-RXN xref: MetaCyc:RXN-7042 xref: MetaCyc:RXN-9679 xref: RHEA:15453 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: gwg creation_date: 2011-08-16T03:45:39Z [Term] id: GO:0052731 name: phosphocholine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: choline phosphate + H2O = choline + phosphate." [EC:3.1.3.75] synonym: "3X11A" RELATED [EC:3.1.3.75] synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75] xref: EC:3.1.3.75 xref: KEGG_REACTION:R06871 xref: MetaCyc:RXN-5647 xref: Reactome:R-HSA-1483159 "PCho is dephosphorylated to Cho by PHOSPHO1" xref: RHEA:10492 is_a: GO:0016791 ! phosphatase activity created_by: gwg creation_date: 2011-08-16T04:09:06Z [Term] id: GO:0052732 name: phosphoethanolamine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate." [EC:3.1.3.75] synonym: "3X11A" RELATED [EC:3.1.3.75] synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75] xref: EC:3.1.3.75 xref: KEGG_REACTION:R06870 xref: MetaCyc:RXN-7948 xref: Reactome:R-HSA-1483096 "PETA is dephosphorylated to ETA by PHOSPHO1" xref: RHEA:16089 is_a: GO:0016791 ! phosphatase activity created_by: gwg creation_date: 2011-08-16T04:09:19Z [Term] id: GO:0052733 name: quinate 3-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+." [RHEA:18425] synonym: "quinate:NADP 3-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinate:NADP(+) 3-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24] xref: EC:1.1.1.282 xref: KEGG_REACTION:R06846 xref: RHEA:18425 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2011-08-16T04:23:47Z [Term] id: GO:0052734 name: shikimate 3-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+." [RHEA:17741] synonym: "3-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "3-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25] synonym: "DHS reductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate:NAD(P)(+) 3-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NAD(P)(+) oxidoreductase activity" BROAD [EC:1.1.1.25] xref: EC:1.1.1.282 xref: KEGG_REACTION:R06847 xref: RHEA:17741 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2011-08-16T04:28:23Z [Term] id: GO:0052735 name: tRNA (cytosine-3-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine." [PMID:21518804, PMID:21518805] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity" EXACT [] synonym: "transfer ribonucleate cytosine 3-methyltransferase activity" EXACT [] synonym: "tRNA (cytosine 3)-methyltransferase activity" EXACT [] synonym: "tRNA cytosine 3-methyltransferase activity" EXACT [] synonym: "tRNA cytosine-3-methyltransferase activity" EXACT [] is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity [Term] id: GO:0052736 name: beta-glucanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds." [Wikipedia:Beta-glucan] synonym: "beta-D-glucanase activity" EXACT [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds creation_date: 2011-08-19T03:40:56Z [Term] id: GO:0052737 name: pyruvate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2." [EC:1.2.5.1] synonym: "pyruvate dehydrogenase activity" BROAD [EC:1.2.5.1] synonym: "pyruvate:ubiquinone oxidoreductase activity" EXACT systematic_synonym [EC:1.2.5.1] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.5.1] synonym: "pyruvic dehydrogenase activity" BROAD [EC:1.2.5.1] xref: EC:1.2.5.1 xref: KEGG_REACTION:R03145 xref: MetaCyc:RXN-11496 xref: RHEA:27405 is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor [Term] id: GO:0052738 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [EC:1.2.5] xref: EC:1.2.5 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0052739 name: phosphatidylserine 1-acylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG_REACTION:R04034] synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32] xref: EC:3.1.1.32 xref: KEGG_REACTION:R04034 xref: Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS" is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0052740 name: 1-acyl-2-lysophosphatidylserine acylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32] xref: EC:3.1.1.32 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0052741 name: (R)-limonene 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+." [EC:1.14.14.53, RHEA:18957] synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.14.53] synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.14.53] synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT systematic_synonym [EC:1.14.14.53] xref: EC:1.14.14.53 xref: KEGG_REACTION:R06119 xref: MetaCyc:1.14.13.84-RXN xref: RHEA:18957 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0052742 name: phosphatidylinositol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation created_by: gwg creation_date: 2011-09-14T01:21:47Z [Term] id: GO:0052743 name: inositol tetrakisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate." [GOC:ai] is_a: GO:0052745 ! inositol phosphate phosphatase activity created_by: gwg creation_date: 2011-09-14T01:31:39Z [Term] id: GO:0052744 name: phosphatidylinositol monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate." [GOC:ai] is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity created_by: gwg creation_date: 2011-09-14T01:36:39Z [Term] id: GO:0052745 name: inositol phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai] is_a: GO:0016791 ! phosphatase activity created_by: gwg creation_date: 2011-09-14T01:50:04Z [Term] id: GO:0052746 name: inositol phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [CHEBI:24848, ISBN:0198506732] synonym: "inositol and derivative phosphorylation" RELATED [] synonym: "myo-inositol and derivative phosphorylation" RELATED [] synonym: "myo-inositol phosphorylation" NARROW [] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation created_by: gwg creation_date: 2011-09-14T01:55:23Z [Term] id: GO:0052747 name: sinapyl alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+." [GOC:mengo_curators, MetaCyc:RXN-1125] synonym: "sinapyl-alcohol dehydrogenase activity" EXACT [EC:1.1.1.195] synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.1.1.195] xref: EC:1.1.1.195 xref: KEGG_REACTION:R03918 xref: MetaCyc:RXN-1125 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor creation_date: 2011-09-21T12:42:06Z [Term] id: GO:0052748 name: baicalin beta-D-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate." [GOC:mengo_curators, RHEA:28130] synonym: "5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity" EXACT [EC:3.2.1.167] synonym: "baicalinase activity" BROAD [EC:3.2.1.167] xref: EC:3.2.1.167 xref: KEGG_REACTION:R09533 xref: MetaCyc:RXN-11760 xref: RHEA:28130 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-09-21T12:58:43Z [Term] id: GO:0052749 name: glucose-6-phosphate dehydrogenase (coenzyme F420) activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420." [EC:1.1.98.2, GOC:mengo_curators, RHEA:27294] synonym: "coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity" EXACT [EC:1.1.98.2] synonym: "D-glucose-6-phosphate:F420 1-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.98.2] synonym: "F420-dependent glucose-6-phosphate dehydrogenase activity" EXACT [EC:1.1.98.2] xref: EC:1.1.98.2 xref: KEGG_REACTION:R09550 xref: MetaCyc:RXN-11283 xref: RHEA:27294 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: gwg creation_date: 2011-09-21T01:21:54Z [Term] id: GO:0052750 name: reactive-black-5:hydrogen-peroxide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O." [KEGG_REACTION:R07612, MetaCyc:RXN-8666] synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16] xref: EC:1.11.1.16 xref: KEGG_REACTION:R07612 xref: MetaCyc:RXN-8666 is_a: GO:0004601 ! peroxidase activity created_by: gwg creation_date: 2011-09-21T02:33:34Z [Term] id: GO:0052751 name: GDP-mannose hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate." [PMID:16766526] synonym: "GDP-mannose pyrophosphatase activity" RELATED [PMID:16766526] is_a: GO:0016462 ! pyrophosphatase activity created_by: gwg creation_date: 2011-09-21T04:11:30Z [Term] id: GO:0052752 name: reduced coenzyme F420:heterodisulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH." [GOC:mengo_curators, PMID:9914308] synonym: "coenzyme F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308] synonym: "F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308] synonym: "F420H2:heterodisulfide oxidoreductase activity" EXACT [] is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors created_by: gwg creation_date: 2011-09-21T04:21:16Z [Term] id: GO:0052753 name: propan-2-ol:coenzyme F420 oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420." [GOC:mengo_curators, PMID:15016352, PMID:1879431, PMID:8706724] synonym: "F420-dependent propan-2-ol dehydrogenase activity" EXACT [] synonym: "F420-dependent secondary alcohol dehydrogenase activity" BROAD [] synonym: "isopropanol:coenzyme F420 oxidoreductase activity" EXACT [] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors creation_date: 2011-09-21T05:15:28Z [Term] id: GO:0052754 name: GTP:coenzyme F420 guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate." [GOC:mengo_curators, MetaCyc:MONOMER-13942, MetaCyc:RXN-9385] synonym: "coenzyme F390-G synthetase activity" EXACT [] synonym: "GTP:coenzyme F420 guanylyltransferase activity" EXACT [] is_a: GO:0070568 ! guanylyltransferase activity created_by: gwg creation_date: 2011-09-22T03:25:30Z [Term] id: GO:0052755 name: reduced coenzyme F420:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone." [GOC:mengo_curators, PMID:10971593, PMID:8055920] synonym: "F420H2-dependent quinone oxidoreductase activity" EXACT [] synonym: "F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity" EXACT [] synonym: "F420H2:quinone oxidoreductase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity created_by: gwg creation_date: 2011-09-22T04:08:13Z [Term] id: GO:0052756 name: chitobiose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units." [GOC:mengo_curators, PMID:15274915, Wikipedia:chitobiose] is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity created_by: gwg creation_date: 2011-09-27T04:04:53Z [Term] id: GO:0052757 name: chondroitin hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]." [GOC:mengo_curators, PMID:18390555] synonym: "chondroitin endo-beta-galactosaminidase activity" EXACT [PMID:18390555] xref: EC:2.4.1 is_a: GO:0033931 ! endogalactosaminidase activity created_by: gwg creation_date: 2011-09-28T10:31:53Z [Term] id: GO:0052758 name: coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1065] synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity" EXACT [] synonym: "TNP reductase activity" BROAD [] xref: EC:1.3.99 xref: UM-BBD_reactionID:r1065 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors created_by: gwg creation_date: 2011-09-28T11:06:03Z [Term] id: GO:0052759 name: coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity namespace: molecular_function def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, UM-BBD_reactionID:r1066] synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity" EXACT [] xref: EC:1.3.99 xref: UM-BBD_reactionID:r1066 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors creation_date: 2011-09-28T01:50:17Z [Term] id: GO:0052760 name: coenzyme F420-dependent 2,4-dinitrophenol reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1071] synonym: "coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity" EXACT [] synonym: "DNP reductase activity" BROAD [] xref: EC:1.3.99 xref: UM-BBD_reactionID:r1071 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors created_by: gwg creation_date: 2011-09-28T02:47:31Z [Term] id: GO:0052761 name: exo-1,4-beta-D-glucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units." [EC:3.2.1.165, GOC:mengo_curators, MetaCyc:3.2.1.165-RXN] synonym: "chitosan exo-1,4-beta-D-glucosaminidase activity" EXACT [KEGG_REACTION:R08715] synonym: "chitosan glucosaminohydrolase activity" EXACT [KEGG_REACTION:R08715] synonym: "exo-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.165] synonym: "exochitosanase activity" EXACT [EC:3.2.1.165] xref: EC:3.2.1.165 xref: KEGG_REACTION:R08715 xref: MetaCyc:3.2.1.165-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-09-28T03:30:54Z [Term] id: GO:0052762 name: gellan lyase activity namespace: molecular_function def: "Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)." [GOC:mengo_curators, MetaCyc:RXN-12269] xref: EC:4.2.2.25 xref: MetaCyc:RXN-12269 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides created_by: gwg creation_date: 2011-09-29T03:19:25Z [Term] id: GO:0052763 name: ulvan lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end." [GOC:mengo_curators, PMID:9468631] is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides created_by: gwg creation_date: 2011-09-29T03:39:23Z [Term] id: GO:0052764 name: exo-oligoalginate lyase activity namespace: molecular_function def: "Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [GOC:mengo_curators, PMID:20925655] xref: EC:4.2.2.26 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides created_by: gwg creation_date: 2011-09-29T04:05:44Z [Term] id: GO:0052765 name: reduced coenzyme F420 oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O." [GOC:mengo_curators, PMID:15340796] synonym: "coenzyme F420H2 oxidase activity" EXACT [] synonym: "F420H2 oxidase activity" EXACT [] synonym: "F420H2:oxygen oxidoreductase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity created_by: gwg creation_date: 2011-09-29T04:33:54Z [Term] id: GO:0052766 name: mannoside alpha-1,4-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [GOC:mengo_curators, PMID:20081828] synonym: "alpha-1,4-exomannosidase activity" BROAD [] synonym: "alpha-1,4-mannosidase activity" BROAD [] synonym: "mannoside alpha-1,4-exomannosidase activity" EXACT [] synonym: "mannoside exo-alpha-1,4-mannosidase activity" EXACT [] is_a: GO:0004559 ! alpha-mannosidase activity created_by: gwg creation_date: 2011-09-30T12:55:24Z [Term] id: GO:0052767 name: mannosyl-oligosaccharide 1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081] synonym: "1,6-alpha-mannosidase activity" BROAD [] synonym: "1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] synonym: "alpha-1,6-mannosidase activity" BROAD [] synonym: "alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] xref: EC:3.1.1 is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity created_by: gwg creation_date: 2011-09-30T12:55:24Z [Term] id: GO:0052768 name: mannosyl-oligosaccharide 1,3-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081] synonym: "1,3-alpha-mannosidase activity" BROAD [] synonym: "1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] synonym: "alpha-1,3-mannosidase activity" BROAD [] synonym: "alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] xref: EC:3.1.1 is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity created_by: gwg creation_date: 2011-09-30T12:55:24Z [Term] id: GO:0052769 name: beta-6-sulfate-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative." [GOC:mengo_curators, PMID:15716424] synonym: "beta-6-SO3-N-acetylglucosaminidase activity" BROAD [] synonym: "exosulfoglycosidase activity" BROAD [] synonym: "sulfoglycosidase activity" BROAD [] synonym: "sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity" EXACT [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-09-30T12:55:24Z [Term] id: GO:0052770 name: coenzyme F390-A hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911] synonym: "8-hydroxyadenylylated-coenzyme F420 hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity created_by: gwg creation_date: 2011-10-03T12:00:00Z [Term] id: GO:0052771 name: coenzyme F390-G hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911] synonym: "8-hydroxyguanylylated-coenzyme F420 hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity created_by: gwg creation_date: 2011-10-03T12:00:00Z [Term] id: GO:0052772 name: brefeldin A esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone." [GOC:mengo_curators, PMID:10201402, PMID:8106385] synonym: "BFA esterase activity" BROAD [] synonym: "brefeldin A hydrolase activity" EXACT [] is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: gwg creation_date: 2011-10-03T12:01:00Z [Term] id: GO:0052773 name: diacetylchitobiose deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)." [GOC:bf, GOC:mengo_curators, MetaCyc:RXN-12543, PMID:15136574, PMID:16232910, PMID:16736587] comment: In this reaction N,N'-diacetylchitobiose is deacetylated at the non-reducing residue to produce 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). This is in contrast to EC:3.5.1.105 in which N,N'-diacetylchitobiose is deacetylated at the reducing residue to produce 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine (GlcNAc-GlcN). For the latter reaction, see GO:0036311. synonym: "N,N'-diacetylchitobiose deacetylase (nonreducing end)" EXACT [MetaCyc:RXN-12543] xref: MetaCyc:RXN-12543 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: gwg creation_date: 2011-10-03T12:01:05Z [Term] id: GO:0052774 name: glucosyl-N-acetylglucosamine glucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine." [GOC:mengo_curators, PMID:15136574, PMID:16232910, PMID:16736587] is_a: GO:0015929 ! hexosaminidase activity created_by: gwg creation_date: 2011-10-03T12:01:05Z [Term] id: GO:0052775 name: endo-1,3-alpha-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain." [GOC:mengo_curators, PMID:10439404] synonym: "endo-(1,3)-alpha-L-rhamnosidase activity" EXACT [] synonym: "endo-(1->3)-alpha-L-rhamnosidase activity" EXACT [] synonym: "endorhamnosidase activity" BROAD [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-10-05T03:30:33Z [Term] id: GO:0052776 name: diacetylchitobiose catabolic process to glucosamine and acetate namespace: biological_process def: "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587] is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:0006083 ! acetate metabolic process is_a: GO:0052777 ! diacetylchitobiose catabolic process relationship: has_part GO:0050119 ! N-acetylglucosamine deacetylase activity relationship: has_part GO:0052761 ! exo-1,4-beta-D-glucosaminidase activity relationship: has_part GO:0052773 ! diacetylchitobiose deacetylase activity [Term] id: GO:0052777 name: diacetylchitobiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products." [PMID:22797760] synonym: "diacetylchitobiose catabolism" EXACT [GOC:obol] is_a: GO:0052778 ! diacetylchitobiose metabolic process is_a: GO:0052782 ! amino disaccharide catabolic process [Term] id: GO:0052778 name: diacetylchitobiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose." [PMID:22797760] synonym: "diacetylchitobiose metabolism" EXACT [GOC:obol] is_a: GO:0052779 ! amino disaccharide metabolic process [Term] id: GO:0052779 name: amino disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [CHEBI:22480] is_a: GO:1901135 ! carbohydrate derivative metabolic process creation_date: 2011-10-03T08:47:05Z [Term] id: GO:0052780 name: chitobiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [CHEBI:50674] is_a: GO:0052779 ! amino disaccharide metabolic process created_by: gwg creation_date: 2011-10-03T08:48:09Z [Term] id: GO:0052781 name: chitobiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [CHEBI:50674] is_a: GO:0052782 ! amino disaccharide catabolic process created_by: gwg creation_date: 2011-10-03T08:54:17Z [Term] id: GO:0052782 name: amino disaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [CHEBI:22480] is_a: GO:0052779 ! amino disaccharide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process created_by: gwg creation_date: 2011-10-03T08:56:04Z [Term] id: GO:0052783 name: reuteran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [PMID:15256553, PMID:16000808] is_a: GO:0030978 ! alpha-glucan metabolic process created_by: gwg creation_date: 2011-10-04T09:16:35Z [Term] id: GO:0052784 name: reuteran biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [GOC:mengo_curators, PMID:15256553, PMID:16000808] synonym: "reuteransucrase-mediated reuteran biosynthesis" NARROW [] is_a: GO:0030979 ! alpha-glucan biosynthetic process is_a: GO:0052783 ! reuteran metabolic process created_by: gwg creation_date: 2011-10-04T09:20:35Z [Term] id: GO:0052785 name: cellulose catabolism by endo-processive cellulases namespace: biological_process def: "The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments." [GOC:mengo_curators, PMID:18035374] synonym: "endo-processive cellulase activity" RELATED [] is_a: GO:0030245 ! cellulose catabolic process created_by: gwg creation_date: 2011-10-04T09:31:16Z [Term] id: GO:0052786 name: alpha-linked polysaccharide catabolism to maltotriose namespace: biological_process def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose." [GOC:mengo_curators, PMID:7511484, PMID:9406414] synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltotriose" EXACT [] synonym: "maltotriose-forming alpha-amylase activity" RELATED [] is_a: GO:0000272 ! polysaccharide catabolic process created_by: gwg creation_date: 2011-10-04T09:59:59Z [Term] id: GO:0052787 name: alpha-linked polysaccharide catabolism to maltopentaose namespace: biological_process def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose." [GOC:mengo_curators, PMID:7511484, PMID:9406414] synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose" EXACT [] synonym: "maltopentaose-forming alpha-amylase activity" RELATED [] is_a: GO:0000272 ! polysaccharide catabolic process created_by: gwg creation_date: 2011-10-04T10:06:44Z [Term] id: GO:0052788 name: d-4,5 unsaturated beta-glucuronyl hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue." [GOC:mengo_curators, PMID:12729728] synonym: "unsaturated beta-glucuronyl hydrolase activity" EXACT [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-10-04T12:59:37Z [Term] id: GO:0052789 name: mannan 1,3-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose." [EC:3.2.1.78, GOC:mengo_curators] synonym: "1,3-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-1,3-mannan 3-mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "exo-1,3-beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "exo-1,3-mannanase activity" EXACT [EC:3.2.1.78] synonym: "exo-beta-1,3-mannase activity" EXACT [EC:3.2.1.78] is_a: GO:0004567 ! beta-mannosidase activity created_by: gwg creation_date: 2011-10-04T01:11:41Z [Term] id: GO:0052790 name: chitooligosaccharide deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions." [GOC:mengo_curators, PMID:8421697, PMID:8986807] xref: EC:3.5.1 is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: gwg creation_date: 2011-10-04T03:48:35Z [Term] id: GO:0052791 name: 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain." [GOC:mengo_curators, PMID:21247893] synonym: "2-keto-3-deoxynononic acid sialidase activity" EXACT [] is_a: GO:0016997 ! alpha-sialidase activity created_by: gwg creation_date: 2011-10-04T04:53:49Z [Term] id: GO:0052792 name: endo-xylogalacturonan hydrolase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position." [GOC:mengo_curators, PMID:10618200] synonym: "endo-galacturonase activity" BROAD [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: gwg creation_date: 2011-10-05T03:57:30Z [Term] id: GO:0052793 name: pectin acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin." [GOC:mengo_curators, PMID:9218776] is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: gwg creation_date: 2011-10-05T05:17:21Z [Term] id: GO:0052794 name: exo-alpha-(2->3)-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] synonym: "exo-alpha-(2,3)-sialidase activity" EXACT [] synonym: "exo-alpha-2,3-sialidase activity" EXACT [] xref: EC:3.2.1.18 is_a: GO:0004308 ! exo-alpha-sialidase activity [Term] id: GO:0052795 name: exo-alpha-(2->6)-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] synonym: "exo-alpha-(2,6)-sialidase activity" EXACT [] synonym: "exo-alpha-2,6-sialidase activity" EXACT [] xref: EC:3.2.1.18 is_a: GO:0004308 ! exo-alpha-sialidase activity [Term] id: GO:0052796 name: exo-alpha-(2->8)-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] synonym: "exo-alpha-(2,8)-sialidase activity" EXACT [] synonym: "exo-alpha-2,8-sialidase activity" EXACT [] xref: EC:3.2.1.18 is_a: GO:0004308 ! exo-alpha-sialidase activity [Term] id: GO:0052797 name: 4-O-methyl-glucuronoyl methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]." [GOC:mengo_curators, PMID:16876163] synonym: "glucuronoyl esterase activity" BROAD [PMID:16876163] is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0052798 name: beta-galactoside alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor." [GOC:mengo_curators, PMID:7826016, PMID:8405811] synonym: "trans-sialidase activity" BROAD [] is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0052799 name: coenzyme F420-dependent bicyclic nitroimidazole catabolic process namespace: biological_process def: "The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates." [GOC:mengo_curators, PMID:16387854, PMID:19039139] synonym: "coenzyme F420-dependent nitroimidazole breakdown" EXACT [] synonym: "coenzyme F420-dependent nitroimidazole catabolism" EXACT [] synonym: "coenzyme F420-dependent nitroimidazole reduction" EXACT [] synonym: "coenzyme F420-dependent nitroreductase activity" RELATED [] is_a: GO:0052800 ! bicyclic nitroimidazole catabolic process [Term] id: GO:0052800 name: bicyclic nitroimidazole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole." [PMID:16387854, PMID:19039139] synonym: "bicyclic nitroimidazole breakdown" EXACT [] synonym: "bicyclic nitroimidazole catabolism" EXACT [] synonym: "bicyclic nitroimidazole degradation" EXACT [] is_a: GO:0052801 ! bicyclic nitroimidazole metabolic process is_a: GO:0052804 ! nitroimidazole catabolic process [Term] id: GO:0052801 name: bicyclic nitroimidazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring." [PMID:16387854, PMID:19039139] synonym: "bicyclic nitroimidazole metabolism" EXACT [] is_a: GO:0052802 ! nitroimidazole metabolic process [Term] id: GO:0052802 name: nitroimidazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139] synonym: "nitroimidazole metabolism" EXACT [] is_a: GO:0052803 ! imidazole-containing compound metabolic process [Term] id: GO:0052803 name: imidazole-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [CHEBI:24780] synonym: "imidazole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0052804 name: nitroimidazole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139] synonym: "nitroimidazole breakdown" EXACT [] synonym: "nitroimidazole catabolism" EXACT [] synonym: "nitroimidazole degradation" EXACT [] is_a: GO:0052805 ! imidazole-containing compound catabolic process [Term] id: GO:0052805 name: imidazole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [CHEBI:24780] synonym: "imidazole breakdown" EXACT [] synonym: "imidazole catabolism" EXACT [] synonym: "imidazole degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0052806 name: sulfite reductase (coenzyme F420) activity namespace: molecular_function def: "Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:16048999] synonym: "coenzyme F420-dependent sulfite reductase activity" EXACT [] synonym: "coenzyme F420-sulfite reductase activity" EXACT [] synonym: "hydrogen-sulfide:coenzyme F420 oxidoreductase activity" EXACT [] synonym: "sulfite:reduced coenzyme F420 reductase activity" EXACT [] is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors created_by: gwg creation_date: 2011-09-22T04:08:13Z [Term] id: GO:0052807 name: aflatoxin reductase (coenzyme F420) activity namespace: molecular_function def: "Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:20807200] synonym: "aflatoxin:coenzyme F420 oxidoreductase activity" EXACT [] synonym: "aflatoxin:reduced coenzyme F420 reductase activity" EXACT [] synonym: "coenzyme F420-aflatoxin reductase activity" EXACT [] synonym: "coenzyme F420-dependent aflatoxin reductase activity" EXACT [] is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors relationship: part_of GO:0046223 ! aflatoxin catabolic process created_by: gwg creation_date: 2011-09-22T04:08:13Z [Term] id: GO:0052808 name: reduced coenzyme F420:NADP+ oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:11726492] synonym: "coenzyme F420-dependent NADP oxidoreductase activity" EXACT [] synonym: "coenzyme F420-dependent NADP reductase activity" EXACT [] synonym: "F420H2:NADP oxidoreductase activity" EXACT [] synonym: "F420H2:NADP+ oxidoreductase activity" EXACT [] synonym: "NADP+:F420 oxidoreductase activity" EXACT [] xref: EC:1.5.1.40 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H created_by: gwg creation_date: 2011-09-22T04:08:13Z [Term] id: GO:0052809 name: acharan sulfate lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid." [GOC:mengo_curators, PMID:19566715] is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides created_by: gwg creation_date: 2011-09-26T02:58:28Z [Term] id: GO:0052810 name: 1-phosphatidylinositol-5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.137] synonym: "1-phosphatidylinositol 5-kinase activity" EXACT [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity" EXACT [EC:2.7.1.137] xref: EC:2.7.1 xref: Reactome:R-HSA-1675810 "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane" xref: Reactome:R-HSA-1675866 "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane" is_a: GO:0052742 ! phosphatidylinositol kinase activity created_by: gwg creation_date: 2011-10-21T03:37:20Z [Term] id: GO:0052811 name: 1-phosphatidylinositol-3-phosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 4-kinase activity" EXACT [EC:2.7.1.150] xref: Reactome:R-HSA-1676145 "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane" is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity created_by: gwg creation_date: 2011-10-21T03:47:58Z [Term] id: GO:0052812 name: phosphatidylinositol-3,4-bisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.153] xref: EC:2.7.1.153 xref: Reactome:R-HSA-1675773 "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane" is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity created_by: gwg creation_date: 2011-10-21T03:52:02Z [Term] id: GO:0052813 name: phosphatidylinositol bisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate." [GOC:ai] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation created_by: gwg creation_date: 2011-10-21T03:55:36Z [Term] id: GO:0052814 name: medium-chain-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons." [EC:1.2.1.48] synonym: "medium-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "medium-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "medium-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] xref: EC:1.2.1 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity creation_date: 2011-10-25T03:04:41Z [Term] id: GO:0052815 name: medium-chain acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length." [EC:3.1.2.19] synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] is_a: GO:0047617 ! acyl-CoA hydrolase activity created_by: gwg creation_date: 2011-10-25T05:26:29Z [Term] id: GO:0052816 name: long-chain acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length." [EC:3.1.2.19] synonym: "long-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "long-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "long-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "long-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] is_a: GO:0047617 ! acyl-CoA hydrolase activity created_by: gwg creation_date: 2011-10-25T05:31:11Z [Term] id: GO:0052817 name: very long chain acyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18." [EC:3.1.2.19] synonym: "very long-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] synonym: "very long-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] synonym: "very long-chain hydrolase activity" EXACT [EC:3.1.2.19] synonym: "very long-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] is_a: GO:0052816 ! long-chain acyl-CoA hydrolase activity created_by: gwg creation_date: 2011-10-27T12:18:28Z [Term] id: GO:0052818 name: heteroglycan 3-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:RXN-7992] synonym: "GDP mannose 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "heteropolysaccharide 3-alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.48 xref: KEGG_REACTION:R03769 xref: MetaCyc:RXN-7992 is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity created_by: gwg creation_date: 2011-10-27T12:36:10Z [Term] id: GO:0052819 name: heteroglycan 2-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN] synonym: "GDP mannose 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] synonym: "heteropolysaccharide 2-alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.48 xref: KEGG_REACTION:R03768 xref: MetaCyc:2.4.1.48-RXN is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity created_by: gwg creation_date: 2011-10-27T12:36:19Z [Term] id: GO:0052820 name: DNA-1,N6-ethenoadenine N-glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar." [PMID:21960007] synonym: "1,N(6)-ethenoadenine N-glycosylase activity" EXACT [] synonym: "1,N6-ethenoadenine glycosylase activity" EXACT [] is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity creation_date: 2011-10-28T01:17:21Z [Term] id: GO:0052821 name: DNA-7-methyladenine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site." [GOC:jl, PMID:16468998] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity created_by: gwg creation_date: 2011-10-28T02:27:39Z [Term] id: GO:0052822 name: DNA-3-methylguanine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] synonym: "3-methylguanine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methylguanine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity created_by: gwg creation_date: 2011-10-28T02:28:19Z [Term] id: GO:0052823 name: 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+." [RHEA:25046] synonym: "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14] synonym: "2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r1622] xref: EC:3.7.1.14 xref: MetaCyc:RXN-12070 xref: RHEA:25046 xref: UM-BBD_reactionID:r1622 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances created_by: gwg creation_date: 2011-10-28T03:28:37Z [Term] id: GO:0052824 name: dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol." [PMID:10336995] is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity created_by: gwg creation_date: 2011-10-28T03:57:17Z [Term] id: GO:0052825 name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855219 "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol" is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity creation_date: 2011-11-29T09:49:22Z [Term] id: GO:0052826 name: inositol hexakisphosphate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.62] xref: EC:3.1.3.62 xref: Reactome:R-HSA-1855225 "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen" is_a: GO:0004446 ! inositol-hexakisphosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T09:52:14Z [Term] id: GO:0052827 name: inositol pentakisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate." [GOC:bf] is_a: GO:0052745 ! inositol phosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T09:55:04Z [Term] id: GO:0052828 name: inositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] xref: Reactome:R-HSA-1855202 "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol" is_a: GO:0016312 ! inositol bisphosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T09:57:00Z [Term] id: GO:0052829 name: inositol-1,3,4-trisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855232 "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol" is_a: GO:0046030 ! inositol trisphosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T09:58:00Z [Term] id: GO:0052830 name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855171 "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol" is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T10:56:59Z [Term] id: GO:0052831 name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: Reactome:R-HSA-1855159 "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol" is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T10:58:27Z [Term] id: GO:0052832 name: inositol monophosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN xref: Reactome:R-HSA-1855210 "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol" is_a: GO:0052834 ! inositol monophosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T11:00:09Z [Term] id: GO:0052833 name: inositol monophosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [] xref: EC:3.1.3.25 xref: MetaCyc:RXN-10952 xref: Reactome:R-HSA-1855211 "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol" is_a: GO:0052834 ! inositol monophosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T11:02:15Z [Term] id: GO:0052834 name: inositol monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] synonym: "inositol phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "L-myo-inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol monophosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:RXN-10949 is_a: GO:0052745 ! inositol phosphate phosphatase activity created_by: gwg creation_date: 2011-11-29T11:15:58Z [Term] id: GO:0052835 name: inositol-3,4,6-trisphosphate 1-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] synonym: "1D-myo-inositol-trisphosphate 1-kinase activity" BROAD [] synonym: "ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 3,4,6-trisphosphate 1-kinase activity" EXACT [] synonym: "inositol-trisphosphate 1-kinase activity" BROAD [] synonym: "ins(3,4,6)P(3) 1-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(3,4,6)P3 1-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 1-kinase activity" BROAD [EC:2.7.1.127] xref: EC:2.7.1 xref: Reactome:R-HSA-1855169 "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol" is_a: GO:0051766 ! inositol trisphosphate kinase activity created_by: gwg creation_date: 2011-11-29T01:06:01Z [Term] id: GO:0052836 name: inositol 5-diphosphate pentakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate." [PMID:11502751, PMID:18355727] xref: Reactome:R-HSA-1855158 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol" xref: Reactome:R-HSA-1855224 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: gwg creation_date: 2011-11-29T01:14:22Z [Term] id: GO:0052837 name: thiazole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [CHEBI:43732, GOC:curators] synonym: "thiazole anabolism" EXACT [] synonym: "thiazole biosynthesis" EXACT [] synonym: "thiazole formation" EXACT [] synonym: "thiazole synthesis" EXACT [] is_a: GO:0018131 ! oxazole or thiazole biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052838 ! thiazole metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: gwg creation_date: 2011-11-29T03:33:05Z [Term] id: GO:0052838 name: thiazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [CHEBI:43732, GOC:curators] synonym: "thiazole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046484 ! oxazole or thiazole metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: gwg creation_date: 2011-11-29T03:35:50Z [Term] id: GO:0052839 name: inositol diphosphate tetrakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate." [PMID:10827188, PMID:11502751, PMID:18355727] xref: Reactome:R-HSA-1855193 "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol" xref: Reactome:R-HSA-1855230 "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: gwg creation_date: 2011-11-29T04:14:22Z [Term] id: GO:0052840 name: inositol diphosphate tetrakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate." [MetaCyc:RXN-10963, PMID:10827188, PMID:11502751] xref: EC:3.6.1.52 xref: MetaCyc:RXN-10963 xref: Reactome:R-HSA-1855166 "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol" is_a: GO:0016462 ! pyrophosphatase activity created_by: gwg creation_date: 2011-11-29T04:14:22Z [Term] id: GO:0052841 name: inositol bisdiphosphate tetrakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate." [MetaCyc:RXN-10965, MetaCyc:RXN-10975, MetaCyc:RXN-10976, PMID:10827188, PMID:11502751] xref: Reactome:R-HSA-1855165 "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol" xref: Reactome:R-HSA-2023973 "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol" is_a: GO:0016462 ! pyrophosphatase activity created_by: gwg creation_date: 2011-11-29T04:14:22Z [Term] id: GO:0052842 name: inositol diphosphate pentakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate." [MetaCyc:RXN-10964, MetaCyc:RXN-10977, MetaCyc:RXN-10978, PMID:10827188, PMID:11502751] xref: EC:3.6.1.52 xref: KEGG_REACTION:R05779 xref: Reactome:R-HSA-1855198 "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" xref: Reactome:R-HSA-2023971 "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" is_a: GO:0016462 ! pyrophosphatase activity created_by: gwg creation_date: 2011-11-29T04:14:22Z [Term] id: GO:0052843 name: inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10977, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10977 is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T10:42:00Z [Term] id: GO:0052844 name: inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10978, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10978 is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T10:59:26Z [Term] id: GO:0052845 name: inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10964, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10964 is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T10:59:20Z [Term] id: GO:0052846 name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10965, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10965 is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T11:02:23Z [Term] id: GO:0052847 name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10975 is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T11:02:23Z [Term] id: GO:0052848 name: inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10976, PMID:10827188, PMID:11502751] xref: MetaCyc:RXN-10976 is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity created_by: gwg creation_date: 2011-12-05T11:02:23Z [Term] id: GO:0052849 name: NADPH-dependent curcumin reductase activity namespace: molecular_function def: "Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+." [MetaCyc:RXN0-6676] xref: EC:1.3.1.n3 xref: MetaCyc:RXN0-6676 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2011-12-05T11:03:23Z [Term] id: GO:0052850 name: NADPH-dependent dihydrocurcumin reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+." [MetaCyc:RXN0-6677] synonym: "dihydrocurcumin reductase (NADPH) activity" EXACT [] xref: MetaCyc:RXN0-6677 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: gwg creation_date: 2011-12-05T11:04:23Z [Term] id: GO:0052851 name: ferric-chelate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ ." [MetaCyc:RXN0-6555] synonym: "Fe(II):NADP+ oxidoreductase activity" EXACT [] synonym: "ferric chelate reductase activity" BROAD [] synonym: "ferric reductase, NADPH-dependent activity" EXACT [] synonym: "iron chelate reductase activity" BROAD [] synonym: "NADPH:Fe3+-EDTA reductase activity" EXACT [] xref: EC:1.16.1.9 xref: KEGG_REACTION:R09541 xref: MetaCyc:RXN0-6555 xref: RHEA:28795 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor created_by: gwg creation_date: 2011-12-05T11:04:23Z [Term] id: GO:0052852 name: very-long-chain-(S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons." [EC:1.1.3.15] synonym: "oxidase, very-long-chain L-2-hydroxy acid" EXACT [EC:1.1.3.15] synonym: "very-long-chain L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "very-long-chain L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "very-long-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "very-long-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "very-long-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "very-long-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15] xref: EC:1.1.3.15 is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity creation_date: 2011-12-05T12:55:03Z [Term] id: GO:0052853 name: long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons." [EC:1.1.3.15] synonym: "long-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "long-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "long-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "long-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "long-chain-L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "long-chain-L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, long-chain-L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: Reactome:R-HSA-6787811 "HAO2 tetramer oxidises 2OH-PALM" is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity creation_date: 2011-12-05T12:55:03Z [Term] id: GO:0052854 name: medium-chain-(S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons." [EC:1.1.3.15] synonym: "medium-chain-(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "medium-chain-hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "medium-chain-hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "medium-chain-hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "medium-chain-L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "medium-chain-L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, medium-chain-L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity creation_date: 2011-12-05T12:55:03Z [Term] id: GO:0052855 name: ADP-dependent NAD(P)H-hydrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, PMID:21994945] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)" EXACT [EC:4.2.1.136] synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.136] synonym: "ADP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] synonym: "ADP-dependent H4NAD(P)OH dehydratase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93] xref: EC:4.2.1.136 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0052856 name: NADHX epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-NADHX = (S)-NADHX." [PMID:21994945] xref: EC:5.1.99.6 xref: RHEA:32215 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0052857 name: NADPHX epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX." [PMID:21994945] xref: EC:5.1.99.6 xref: Reactome:R-HSA-6806966 "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX" xref: RHEA:32227 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0052858 name: peptidyl-lysine acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine." [GOC:tb] synonym: "acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity" EXACT [] synonym: "acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity" EXACT [] synonym: "peptidyl-lysine N(6)-acetyltransferase activity" EXACT [] synonym: "peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" EXACT [] synonym: "peptidyl-lysine N6-acetyltransferase activity" EXACT [] is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0052859 name: glucan endo-1,4-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans." [EC:3.2.1.75] synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [] synonym: "beta-1,4-glucan 4-glucanohydrolase activity" EXACT [] synonym: "beta-1,4-glucan hydrolase activity" EXACT [] synonym: "beta-1,4-glucanase activity" EXACT [] synonym: "beta-1->4-glucan hydrolase activity" EXACT [] synonym: "endo-(1,4)-beta-D-glucanase activity" EXACT [] synonym: "endo-(1->4)-beta-D-glucanase activity" EXACT [] synonym: "endo-1,4-beta-D-glucanase activity" EXACT [] synonym: "endo-1,4-beta-glucanase activity" EXACT [] synonym: "endo-beta-1,4-glucanase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0008422 ! beta-glucosidase activity created_by: gwg creation_date: 2011-12-06T03:48:44Z [Term] id: GO:0052860 name: 2'-deoxymugineic-acid 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25] synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25] xref: EC:1.14.11.25 xref: KEGG_REACTION:R07187 xref: MetaCyc:RXN-7983 xref: RHEA:20065 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity created_by: gwg creation_date: 2011-12-05T06:00:58Z [Term] id: GO:0052861 name: glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] synonym: "1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.6] synonym: "laminaranase activity" RELATED [EC:3.2.1.6] synonym: "laminarinase activity" RELATED [EC:3.2.1.6] xref: EC:3.2.1.6 xref: MetaCyc:3.2.1.6-RXN is_a: GO:0052736 ! beta-glucanase activity created_by: gwg creation_date: 2011-12-06T04:49:36Z [Term] id: GO:0052862 name: glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] synonym: "1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.6] synonym: "laminaranase activity" RELATED [EC:3.2.1.6] synonym: "laminarinase activity" RELATED [EC:3.2.1.6] xref: EC:3.2.1.6 xref: MetaCyc:3.2.1.6-RXN is_a: GO:0052736 ! beta-glucanase activity created_by: gwg creation_date: 2011-12-06T05:27:26Z [Term] id: GO:0052863 name: 1-deoxy-D-xylulose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0052864 name: 1-deoxy-D-xylulose 5-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate breakdown" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate catabolism" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate degradation" EXACT [] is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0052865 name: 1-deoxy-D-xylulose 5-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [CHEBI:16493, KEGG:C11437, PubChem:13609] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation" EXACT [] synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate anabolism" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate biosynthesis" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate formation" EXACT [] synonym: "1-deoxy-D-xylulose 5-phosphate synthesis" EXACT [] xref: UniPathway:UPA00064 is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0052866 name: phosphatidylinositol phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate." [GOC:ai] synonym: "phosphoinositide phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity created_by: gwg creation_date: 2011-12-13T01:20:17Z [Term] id: GO:0052867 name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.-] synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-] synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-] synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [EC:3.1.3.-] synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [EC:3.1.3.-] synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [EC:3.1.3.-] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.-] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.-] xref: EC:3.1.3 is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity creation_date: 2012-01-11T12:07:50Z [Term] id: GO:0052868 name: protein-lysine lysyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine." [PMID:20729861] is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups created_by: gwg creation_date: 2012-01-11T03:05:27Z [Term] id: GO:0052869 name: arachidonic acid omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG_REACTION:R07041] synonym: "arachidonic acid hydroxylase activity" BROAD [] synonym: "arachidonic acid:oxygen 1-oxidoreductase activity" EXACT systematic_synonym [] xref: EC:1.14.15.3 xref: KEGG_REACTION:R07041 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen created_by: gwg creation_date: 2012-01-30T03:05:27Z [Term] id: GO:0052870 name: tocopherol omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] synonym: "tocopherol 13-hydroxylase activity" EXACT systematic_synonym [] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: gwg creation_date: 2012-01-30T03:06:27Z [Term] id: GO:0052871 name: alpha-tocopherol omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] synonym: "alpha-tocopherol 13-hydroxylase activity" EXACT [] xref: MetaCyc:RXN-11003 is_a: GO:0052870 ! tocopherol omega-hydroxylase activity created_by: gwg creation_date: 2012-01-30T03:06:27Z [Term] id: GO:0052872 name: tocotrienol omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ." [MetaCyc:RXN-11003] synonym: "tocotrienol 13-hydroxylase activity" EXACT [] xref: EC:1.14.13 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: gwg creation_date: 2012-01-30T03:07:27Z [Term] id: GO:0052873 name: FMN reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+." [RHEA:21624] synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "FMNH2:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH dehydrogenase (FMN) activity" EXACT [] synonym: "NADPH(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NADPH(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH2 dehydrogenase (FMN)" EXACT [EC:1.5.1.3] synonym: "NADPH2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADPH:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] xref: EC:1.5.1.38 xref: EC:1.5.1.39 xref: KEGG_REACTION:R05706 xref: Reactome:R-HSA-1222399 "Iron is reduced and separates from mycobactin" xref: RHEA:21624 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0052874 name: FMN reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+." [RHEA:21620] synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "FMNH2:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADH dehydrogenase (FMN) activity" EXACT [] synonym: "NADH(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NADH(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADH-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NADH-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NADH2 dehydrogenase (FMN)" EXACT [EC:1.5.1.3] synonym: "NADH2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADH:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NADH:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] xref: EC:1.5.1.39 xref: KEGG_REACTION:R05705 xref: RHEA:21620 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0052875 name: riboflavin reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+." [RHEA:31455] synonym: "flavin mononucleotide reductase activity" RELATED [EC:1.5.1.41] synonym: "flavine mononucleotide reductase activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H-dependent FMN reductase activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H-FMN reductase activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H2 dehydrogenase (FMN) activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H2:FMN oxidoreductase activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H:FMN oxidoreductase activity" RELATED [EC:1.5.1.41] synonym: "NAD(P)H:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.41] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.41] synonym: "riboflavin mononucleotide reductase activity" RELATED [EC:1.5.1.41] synonym: "riboflavine mononucleotide reductase activity" RELATED [EC:1.5.1.41] xref: EC:1.5.1.41 xref: KEGG_REACTION:R09750 xref: MetaCyc:RXN-12445 xref: RHEA:31455 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0052876 name: methylamine dehydrogenase (amicyanin) activity namespace: molecular_function def: "Catalysis of the reaction: methylamine + H2O + amicyanin = formaldehyde + ammonia + reduced amicyanin." [KEGG_REACTION:R00606] synonym: "amine dehydrogenase activity" BROAD [EC:1.4.9.1] synonym: "amine:(acceptor) oxidoreductase (deaminating) activity" BROAD [EC:1.4.9.1] synonym: "MADH activity" BROAD [EC:1.4.9.1] synonym: "methylamine dehydrogenase activity" BROAD [EC:1.4.9.1] synonym: "methylamine:amicyanin oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.9.1] synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.9.1] synonym: "primary-amine:(acceptor) oxidoreductase (deaminating) activity" BROAD [EC:1.4.9.1] xref: EC:1.4.9.1 xref: KEGG_REACTION:R00606 xref: UM-BBD_reactionID:r0075 is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor [Term] id: GO:0052877 name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor." [GOC:ai] xref: EC:1.4.9 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0052878 name: linoleate 8R-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate." [RHEA:25395] synonym: "5,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] synonym: "5,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] synonym: "7,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] synonym: "7,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44] xref: EC:1.13.11.60 xref: KEGG_REACTION:R07061 xref: MetaCyc:1.13.11.44-RXN xref: RHEA:25395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0052879 name: 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate." [RHEA:25399] synonym: "(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity" EXACT [EC:5.4.4.6] synonym: "8-hydroperoxide isomerase activity" BROAD [EC:5.4.4.6] synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44] xref: EC:5.4.4.6 xref: KEGG_REACTION:R07062 xref: MetaCyc:1.13.11.44-RXN xref: RHEA:25399 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0052880 name: oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl] xref: EC:1.10.9 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0052881 name: 4-hydroxyphenylacetate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O." [RHEA:30595] synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.14.9] synonym: "4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT systematic_synonym [] synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" BROAD [EC:1.14.14.9] synonym: "p-hydroxyphenylacetate 3-hydroxylase (FAD) activity" EXACT [EC:1.14.14.9] synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.14.9] synonym: "p-hydroxyphenylacetate hydroxylase (FAD) activity" EXACT [EC:1.14.14.9] synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.14.9] xref: EC:1.14.14.9 xref: MetaCyc:RXN-8505 xref: RHEA:30595 xref: UM-BBD_reactionID:r0301 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0052882 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl] xref: EC:1.20.9 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0052883 name: tyrosine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate." [RHEA:24906] synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.23] synonym: "TAL activity" BROAD [EC:4.3.1.23] synonym: "tyrase activity" BROAD [EC:4.3.1.23] xref: EC:4.3.1.23 xref: EC:4.3.1.25 xref: RHEA:24906 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0052884 name: all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate." [RHEA:31775] synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64] synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64] synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64] synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64] xref: EC:3.1.1.64 xref: Reactome:R-HSA-2453833 "RPE65 isomero-hydrolyses atREs to 11cROL" xref: RHEA:31775 is_a: GO:0052689 ! carboxylic ester hydrolase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0052885 name: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid." [RHEA:31771] synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64] synonym: "all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity" EXACT [EC:3.1.1.64] synonym: "all-trans-retinylester 11-cis isomerohydrolase activity" EXACT [EC:3.1.1.64] synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64] synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64] xref: EC:3.1.1.64 xref: KEGG_REACTION:R08388 xref: MetaCyc:RXN-12550 xref: RHEA:31771 is_a: GO:0052689 ! carboxylic ester hydrolase activity relationship: part_of GO:0042572 ! retinol metabolic process [Term] id: GO:0052886 name: 9,9'-dicis-carotene:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol." [EC:1.3.5.6] synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] synonym: "ZDS activity" BROAD [EC:1.3.5.6] synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] xref: EC:1.3.5.6 xref: KEGG_REACTION:R09656 xref: MetaCyc:RXN-11356 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0052887 name: 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol." [EC:1.3.5.6] synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] synonym: "ZDS activity" BROAD [EC:1.3.5.6] synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] xref: EC:1.3.5.6 xref: KEGG_REACTION:R09658 xref: MetaCyc:RXN-11357 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0052888 name: obsolete dihydroorotate oxidase (fumarate) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [EC:1.3.98.1, RHEA:30059] comment: EC has determined that this reaction in fact does not exist and have withdrawn EC 1.3.3.1. Note: If fumarate is not shown to be involved, you may want to consider GO:0004152, dihydroorotate dehydrogenase activity (parent term); if the reaction involves fumarate, then use GO:0052888 dihydroorotate oxidase (fumarate) activity. Details at http://sourceforge.net/p/geneontology/ontology-requests/10770/ synonym: "DHOD activity" BROAD [EC:1.3.98.1] synonym: "DHOdase activity" BROAD [EC:1.3.98.1] synonym: "DHodehase activity" BROAD [EC:1.3.98.1] synonym: "dihydoorotic acid dehydrogenase activity" BROAD [EC:1.3.98.1] synonym: "dihydroorotate dehydrogenase activity" BROAD [EC:1.3.98.1] synonym: "dihydroorotate oxidase (fumarate) activity" EXACT [] synonym: "dihydroorotate oxidase activity" BROAD [EC:1.3.98.1] xref: EC:1.3.98.1 xref: KEGG_REACTION:R01867 xref: MetaCyc:RXN-9929 xref: RHEA:30059 is_obsolete: true [Term] id: GO:0052889 name: 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene namespace: biological_process def: "The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene." [EC:1.3.5.6, KEGG_REACTION:R07511] synonym: "7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene" EXACT [] synonym: "9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene" EXACT [] synonym: "9,9'-di-cis-zeta-carotene desaturase activity" EXACT [EC:1.3.5.6] synonym: "9,9'-dicis-zeta-carotene:quinone oxidoreductase activity" EXACT [KEGG_REACTION:R07511] synonym: "ZDS activity" BROAD [EC:1.3.5.6] synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] xref: KEGG_REACTION:R07511 xref: MetaCyc:RXN-12242 is_a: GO:0016119 ! carotene metabolic process relationship: has_part GO:0052886 ! 9,9'-dicis-carotene:quinone oxidoreductase activity relationship: has_part GO:0052887 ! 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity [Term] id: GO:0052890 name: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] xref: EC:1.3.8 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0052891 name: aliphatic (S)-hydroxynitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide." [EC:4.1.2.47] synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47] synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47] synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47] xref: EC:4.1.2.47 xref: MetaCyc:RXN-11731 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0052892 name: aromatic (S)-hydroxynitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide." [EC:4.1.2.47, KEGG_REACTION:R09359] synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47] synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47] synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47] xref: EC:4.1.2.47 xref: KEGG_REACTION:R09359 xref: MetaCyc:RXN-11732 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0052893 name: N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide." [MetaCyc:RXN-10465] synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] xref: EC:1.5.3.14 xref: MetaCyc:RXN-10465 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052894 name: norspermine:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:RXN-10464] synonym: "norspermine oxidase activity" BROAD [EC:1.5.3.16] xref: EC:1.5.3.16 xref: MetaCyc:RXN-10464 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052895 name: N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:POLYAMINE-OXIDASE-RXN] synonym: "N1-acetylspermine oxidase activity" BROAD [EC:1.5.3.16] xref: EC:1.5.3.16 xref: MetaCyc:POLYAMINE-OXIDASE-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052896 name: spermidine oxidase (propane-1,3-diamine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2)." [RHEA:25820] synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] synonym: "spermidine:(acceptor) oxidoreductase activity" BROAD [EC:1.5.3.14] xref: EC:1.5.3.14 xref: KEGG_REACTION:R01914 xref: MetaCyc:RXN-10747 xref: RHEA:25820 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052897 name: N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25972] synonym: "N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.15] xref: EC:1.5.3.15 xref: KEGG_REACTION:R09075 xref: MetaCyc:RXN-10463 xref: RHEA:25972 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052898 name: N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25864] xref: EC:1.5.3.15 xref: RHEA:25864 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052899 name: N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine." [RHEA:25868] synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] xref: EC:1.5.3.13 xref: MetaCyc:RXN-10460 xref: RHEA:25868 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052900 name: spermine oxidase (propane-1,3-diamine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal." [RHEA:25824] synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] xref: EC:1.5.3.14 xref: MetaCyc:RXN-6421 xref: RHEA:25824 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052901 name: spermine:oxygen oxidoreductase (spermidine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine." [RHEA:25804] synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] synonym: "spermine oxidase activity" BROAD [EC:1.5.3.16] xref: EC:1.5.3.13 xref: EC:1.5.3.16 xref: EC:1.5.3.17 xref: KEGG_REACTION:R09076 xref: MetaCyc:1.5.3.17-RXN xref: MetaCyc:RXN-9015 xref: Reactome:R-HSA-141341 "SMOX-3 oxidises SPN to SPM" xref: RHEA:25804 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052902 name: spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine." [RHEA:25808] synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] xref: EC:1.5.3.13 xref: EC:1.5.3.17 xref: KEGG_REACTION:R09077 xref: MetaCyc:RXN-10461 xref: MetaCyc:RXN-12089 xref: RHEA:25808 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052903 name: N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine." [RHEA:25800] synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] xref: EC:1.5.3.13 xref: EC:1.5.3.17 xref: KEGG_REACTION:R03899 xref: MetaCyc:RXN-12090 xref: MetaCyc:RXN-9940 xref: RHEA:25800 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052904 name: N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine." [RHEA:25812] synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] xref: EC:1.5.3.13 xref: EC:1.5.3.17 xref: KEGG_REACTION:R09074 xref: MetaCyc:RXN-12091 xref: MetaCyc:RXN-9942 xref: Reactome:R-HSA-141348 "PAO:FAD oxidises NASPM to PTCN" xref: Reactome:R-HSA-141351 "PAOX:FAD oxidises NASPN to SPM" xref: RHEA:25812 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0052905 name: tRNA (guanine(9)-N(1))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.221] synonym: "tRNA (guanine-N(1)-)-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA m(1)G(9) Mtase activity" EXACT [EC:2.1.1.221] synonym: "tRNA m(1)G(9)-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" EXACT [EC:2.1.1.221] xref: EC:2.1.1.221 xref: MetaCyc:RXN-12459 is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity [Term] id: GO:0052906 name: tRNA (guanine(37)-N(1))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.228] synonym: "transfer RNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228] synonym: "tRNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228] synonym: "tRNA-(N(1)G37) methyltransferase activity" EXACT [EC:2.1.1.228] xref: EC:2.1.1.228 xref: MetaCyc:RXN-12458 is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity [Term] id: GO:0052907 name: 23S rRNA (adenine(1618)-N(6))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA." [EC:2.1.1.181] synonym: "M(6)A(1618) activity" BROAD [EC:2.1.1.181] synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181] xref: EC:2.1.1.181 xref: KEGG_REACTION:R07232 xref: MetaCyc:RXN-11596 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] id: GO:0052908 name: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA." [EC:2.1.1.182] synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" EXACT [EC:2.1.1.182] xref: EC:2.1.1.182 xref: MetaCyc:RXN-11633 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] id: GO:0052909 name: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA." [EC:2.1.1.183] synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183] xref: EC:2.1.1.183 xref: MetaCyc:RXN-11634 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] id: GO:0052910 name: 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA." [EC:2.1.1.184] synonym: "ermC 23S rRNA methyltransferase activity" RELATED [EC:2.1.1.184] synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184] synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184] xref: EC:2.1.1.184 xref: MetaCyc:RXN-11597 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] id: GO:0052911 name: 23S rRNA (guanine(745)-N(1))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.187] synonym: "23S rRNA m(1)G(745) methyltransferase activity" EXACT [EC:2.1.1.187] synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" BROAD [EC:2.1.1.187] synonym: "ribosomal RNA(m(1)G)-methylase activity" BROAD [EC:2.1.1.187] synonym: "rlmA(I) methyltransferase activity" BROAD [EC:2.1.1.187] synonym: "rRNA(m(1)G)methylase activity" BROAD [EC:2.1.1.187] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" BROAD [EC:2.1.1.187] xref: EC:2.1.1.187 xref: KEGG_REACTION:R07233 xref: MetaCyc:RXN-11573 xref: RHEA:42900 is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity [Term] id: GO:0052912 name: 23S rRNA (guanine(748)-N(1))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.188] synonym: "23S rRNA m(1)G(748) methyltransferase activity" BROAD [EC:2.1.1.188] xref: EC:2.1.1.188 xref: KEGG_REACTION:R07233 xref: MetaCyc:RXN-11599 xref: RHEA:42904 is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity [Term] id: GO:0052913 name: 16S rRNA (guanine(966)-N(2))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.171] xref: EC:2.1.1.171 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN0-6515 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] id: GO:0052914 name: 16S rRNA (guanine(1207)-N(2))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.172] synonym: "M(2)G1207 methyltransferase activity" EXACT [EC:2.1.1.172] xref: EC:2.1.1.172 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11576 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] id: GO:0052915 name: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.173] xref: EC:2.1.1.173 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11574 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] id: GO:0052916 name: 23S rRNA (guanine(1835)-N(2))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.174] xref: EC:2.1.1.174 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11635 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] id: GO:0052917 name: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.260, RHEA:29535] synonym: "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase activity" EXACT [EC:2.4.1.260] synonym: "dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.260] xref: EC:2.4.1.260 xref: KEGG_REACTION:R06260 xref: MetaCyc:RXN-5468 xref: RHEA:29535 is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity [Term] id: GO:0052918 name: dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.261, RHEA:29539] xref: EC:2.4.1.261 xref: KEGG_REACTION:R06261 xref: MetaCyc:RXN-5469 xref: RHEA:29539 is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity [Term] id: GO:0052919 name: aliphatic (R)-hydroxynitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide." [EC:4.1.2.46] synonym: "(R)-HNL activity" BROAD [EC:4.1.2.46] synonym: "(R)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.46] synonym: "(R)-oxynitrilase activity" BROAD [EC:4.1.2.46] xref: EC:4.1.2.46 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0052920 name: (2R)-2-hydroxy-2-methylbutanenitrile lyase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide." [EC:4.1.2.46] xref: EC:4.1.2.46 xref: KEGG_REACTION:R09358 xref: MetaCyc:RXN-11733 xref: RHEA:28170 is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity [Term] id: GO:0052921 name: acetone-cyanohydrin acetone-lyase (cyanide-forming) activity namespace: molecular_function def: "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone." [KEGG_REACTION:R01553, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] xref: EC:4.1.2.46 xref: KEGG_REACTION:R01553 xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity [Term] id: GO:0052922 name: hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate." [RHEA:27555] synonym: "(all-E) hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82] synonym: "(all-trans)-hexaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.82] synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82] synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.82] xref: EC:2.5.1.82 xref: KEGG_REACTION:R09246 xref: MetaCyc:RXN-11485 xref: RHEA:27555 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052923 name: all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.84, RHEA:27563] synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.84] synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.84] synonym: "solanesyl-diphosphate synthase activity" BROAD [EC:2.5.1.84] synonym: "solPP synthase activity" BROAD [EC:2.5.1.84] synonym: "SPP synthase activity" BROAD [EC:2.5.1.84] synonym: "SPP-synthase activity" BROAD [EC:2.5.1.84] xref: EC:2.5.1.84 xref: KEGG_REACTION:R09250 xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN xref: RHEA:27563 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052924 name: all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.85] synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.85] synonym: "solanesyl diphosphate synthase activity" BROAD [EC:2.5.1.85] synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.85] xref: EC:2.5.1.85 xref: KEGG_REACTION:R09251 xref: MetaCyc:RXN-11486 xref: RHEA:27594 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0052925 name: dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29527] synonym: "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.258] synonym: "man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity" EXACT [EC:2.4.1.258] xref: EC:2.4.1.258 xref: KEGG_REACTION:R06258 xref: MetaCyc:RXN-5466 xref: RHEA:29527 is_a: GO:0000033 ! alpha-1,3-mannosyltransferase activity [Term] id: GO:0052926 name: dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.259, RHEA:29531] synonym: "dolichylphosphomannose-dependent ALG9 mannosyltransferase activity" RELATED [EC:2.4.1.259] xref: EC:2.4.1.259 xref: KEGG_REACTION:R06259 xref: MetaCyc:RXN-5467 xref: RHEA:29531 is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity [Term] id: GO:0052927 name: CTP:tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate." [KEGG_REACTION:R09383] xref: EC:2.7.7.72 xref: KEGG_REACTION:R09383 is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0052928 name: CTP:3'-cytidine-tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate." [KEGG_REACTION:R09384] xref: EC:2.7.7.72 xref: KEGG_REACTION:R09384 is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0052929 name: ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate." [KEGG_REACTION:R09386] synonym: "ATP:3'-CC-tRNA adenylyltransferase activity" EXACT [] synonym: "ATP:tRNA adenylyltransferase activity" BROAD [] xref: EC:2.7.7.72 xref: KEGG_REACTION:R09386 is_a: GO:0004810 ! tRNA adenylyltransferase activity [Term] id: GO:0052930 name: methanol ferricytochrome-c oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: methanol + 2 ferricytochrome c = formaldehyde + 2 ferrocytochrome c + 2 H+." [KEGG_REACTION:R01146] synonym: "methanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7] synonym: "methanol dehydrogenase activity" BROAD [EC:1.1.2.7] xref: EC:1.1.2.7 xref: KEGG_REACTION:R01146 xref: MetaCyc:RXN-2861 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0052931 name: ethanol cytochrome-c oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: ethanol + 2 cytochrome c(L) = acetaldehyde + 2 reduced cytochrome c(L) + 2 H+." [KEGG_REACTION:R09127] synonym: "ethanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7] synonym: "ethanol dehydrogenase activity" BROAD [EC:1.1.2.7] xref: EC:1.1.2.7 xref: KEGG_REACTION:R09127 is_a: GO:0052933 ! alcohol dehydrogenase (cytochrome c(L)) activity [Term] id: GO:0052932 name: 2-chloroethanol cytochrome-c oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c(L) = chloroacetaldehyde + 2 reduced cytochrome c(L)." [KEGG_REACTION:R09128] synonym: "2-chloroethanol dehydrogenase (cytochrome c) activity" BROAD [EC:1.1.2.7] synonym: "2-chloroethanol dehydrogenase activity" BROAD [EC:1.1.2.7] xref: EC:1.1.2.7 xref: KEGG_REACTION:R09128 is_a: GO:0052933 ! alcohol dehydrogenase (cytochrome c(L)) activity [Term] id: GO:0052933 name: alcohol dehydrogenase (cytochrome c(L)) activity namespace: molecular_function def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c(L) = 2 reduced cytochrome c(L) + an aldehyde + 2 H+." [EC:1.1.2.7] synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.7] xref: EC:1.1.2.7 xref: MetaCyc:RXN-11332 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0052934 name: alcohol dehydrogenase (cytochrome c) activity namespace: molecular_function def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c = 2 reduced cytochrome c + an aldehyde + 2 H+." [EC:1.1.2.8] synonym: "alcohol:cytochrome c oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.8] synonym: "quinoprotein alcohol dehydrogenase activity" RELATED [EC:1.1.2.8] xref: EC:1.1.2.8 xref: MetaCyc:RXN-11333 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0052935 name: ethanol:cytochrome c oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: ethanol + 2 cytochrome c = 2 reduced cytochrome c + acetaldehyde." [KEGG_REACTION:R05198] synonym: "ethanol dehydrogenase (cytochrome c) activity" EXACT [EC:1.1.2.8] xref: EC:1.1.2.8 xref: KEGG_REACTION:R05198 xref: RHEA:51020 is_a: GO:0052934 ! alcohol dehydrogenase (cytochrome c) activity [Term] id: GO:0052936 name: 2-chloroethanol:cytochrome c oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c = chloroacetaldehyde + 2 reduced cytochrome c." [KEGG_REACTION:R05285] xref: KEGG_REACTION:R05285 xref: RHEA:55947 is_a: GO:0052934 ! alcohol dehydrogenase (cytochrome c) activity [Term] id: GO:0055001 name: muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] is_a: GO:0048468 ! cell development relationship: part_of GO:0042692 ! muscle cell differentiation [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development relationship: part_of GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0055003 name: cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "cardiac myofibril development" EXACT [] synonym: "cardiac myofibril morphogenesis" EXACT [] synonym: "heart myofibril assembly" RELATED [] is_a: GO:0030239 ! myofibril assembly relationship: part_of GO:0055013 ! cardiac muscle cell development [Term] id: GO:0055004 name: atrial cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "atrial cardiac myofibril development" EXACT [GOC:dph] synonym: "atrial heart myofibril development" EXACT [] is_a: GO:0055003 ! cardiac myofibril assembly relationship: part_of GO:0055014 ! atrial cardiac muscle cell development [Term] id: GO:0055005 name: ventricular cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "ventricular cardiac myofibril development" RELATED [] synonym: "ventricular heart myofibril development" EXACT [] is_a: GO:0055003 ! cardiac myofibril assembly relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development [Term] id: GO:0055006 name: cardiac cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] synonym: "cardiocyte development" EXACT [GOC:dph] synonym: "heart cell development" RELATED [] is_a: GO:0048468 ! cell development relationship: part_of GO:0035051 ! cardiocyte differentiation [Term] id: GO:0055007 name: cardiac muscle cell differentiation namespace: biological_process def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte differentiation" EXACT [] synonym: "heart muscle cell differentiation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055008 name: cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] synonym: "heart muscle morphogenesis" EXACT [] synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055009 name: atrial cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] synonym: "atrial heart muscle morphogenesis" EXACT [] synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac atrium muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development [Term] id: GO:0055010 name: ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] synonym: "cardiac ventricle muscle morphogenesis" EXACT [] synonym: "ventricular heart muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development [Term] id: GO:0055011 name: atrial cardiac muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart] synonym: "atrial cardiomyocyte differentiation" EXACT [] synonym: "atrial heart muscle cell differentiation" EXACT [] is_a: GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055012 name: ventricular cardiac muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart] synonym: "ventricular cardiomyocyte differentiation" EXACT [] synonym: "ventricular heart muscle cell differentiation" EXACT [] is_a: GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055013 name: cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] synonym: "heart muscle cell development" EXACT [] is_a: GO:0055002 ! striated muscle cell development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0055007 ! cardiac muscle cell differentiation [Term] id: GO:0055014 name: atrial cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol] synonym: "atrial cardiomyocyte development" EXACT [] synonym: "atrial heart muscle development" EXACT [] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation [Term] id: GO:0055015 name: ventricular cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle] synonym: "ventricular cardiomyocyte development" EXACT [] synonym: "ventricular heart muscle cell development" EXACT [] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation [Term] id: GO:0055016 name: hypochord development namespace: biological_process def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb] synonym: "subnotochordal rod development" EXACT [] is_a: GO:0009888 ! tissue development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0055017 name: cardiac muscle tissue growth namespace: biological_process def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] synonym: "heart muscle growth" EXACT [] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0060419 ! heart growth [Term] id: GO:0055018 name: regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "regulation of cardiac muscle fibre development" EXACT [] synonym: "regulation of heart muscle fiber development" EXACT [] is_a: GO:0060284 ! regulation of cell development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048739 ! cardiac muscle fiber development relationship: regulates GO:0048739 ! cardiac muscle fiber development [Term] id: GO:0055019 name: negative regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "down regulation of cardiac muscle fiber development" EXACT [] synonym: "down-regulation of cardiac muscle fiber development" EXACT [] synonym: "downregulation of cardiac muscle fiber development" EXACT [] synonym: "inhibition of cardiac muscle fiber development" NARROW [] synonym: "negative regulation of cardiac muscle fibre development" EXACT [] synonym: "negative regulation of heart muscle fiber development" RELATED [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0055018 ! regulation of cardiac muscle fiber development is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048739 ! cardiac muscle fiber development relationship: negatively_regulates GO:0048739 ! cardiac muscle fiber development [Term] id: GO:0055020 name: positive regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "activation of cardiac muscle fiber development" NARROW [] synonym: "positive regulation of cardiac muscle fibre development" EXACT [] synonym: "positive regulation of heart muscle fiber development" EXACT [] synonym: "stimulation of cardiac muscle fiber development" NARROW [] synonym: "up regulation of cardiac muscle fiber development" EXACT [] synonym: "up-regulation of cardiac muscle fiber development" EXACT [] synonym: "upregulation of cardiac muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0055018 ! regulation of cardiac muscle fiber development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048739 ! cardiac muscle fiber development relationship: positively_regulates GO:0048739 ! cardiac muscle fiber development [Term] id: GO:0055021 name: regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055017 ! cardiac muscle tissue growth relationship: regulates GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0055022 name: negative regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "down regulation of cardiac muscle growth" EXACT [] synonym: "down-regulation of cardiac muscle growth" EXACT [] synonym: "downregulation of cardiac muscle growth" EXACT [] synonym: "inhibition of cardiac muscle growth" NARROW [] synonym: "negative regulation of heart muscle growth" RELATED [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development is_a: GO:0061117 ! negative regulation of heart growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055017 ! cardiac muscle tissue growth relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0055023 name: positive regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "activation of cardiac muscle growth" NARROW [] synonym: "positive regulation of heart muscle growth" EXACT [] synonym: "stimulation of cardiac muscle growth" NARROW [] synonym: "up regulation of cardiac muscle growth" EXACT [] synonym: "up-regulation of cardiac muscle growth" EXACT [] synonym: "upregulation of cardiac muscle growth" EXACT [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0055025 ! positive regulation of cardiac muscle tissue development is_a: GO:0060421 ! positive regulation of heart growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055017 ! cardiac muscle tissue growth relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0055024 name: regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "regulation of heart muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048738 ! cardiac muscle tissue development relationship: regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055025 name: positive regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "activation of cardiac muscle development" NARROW [] synonym: "positive regulation of heart muscle development" EXACT [] synonym: "stimulation of cardiac muscle development" NARROW [] synonym: "up regulation of cardiac muscle development" EXACT [] synonym: "up-regulation of cardiac muscle development" EXACT [] synonym: "upregulation of cardiac muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048738 ! cardiac muscle tissue development relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055026 name: negative regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "down regulation of cardiac muscle development" EXACT [] synonym: "down-regulation of cardiac muscle development" EXACT [] synonym: "downregulation of cardiac muscle development" EXACT [] synonym: "inhibition of cardiac muscle development" NARROW [] synonym: "negative regulation of heart muscle development" EXACT [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048738 ! cardiac muscle tissue development relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0055028 name: cortical microtubule namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu] is_a: GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton [Term] id: GO:0055029 name: nuclear DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] is_a: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0055031 name: gamma-tubulin large complex, equatorial microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, eMTOC" EXACT [] synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex intersection_of: GO:0000931 ! gamma-tubulin large complex intersection_of: part_of GO:0000923 ! equatorial microtubule organizing center relationship: part_of GO:0000923 ! equatorial microtubule organizing center [Term] id: GO:0055032 name: gamma-tubulin large complex, spindle pole body namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu] is_a: GO:0000931 ! gamma-tubulin large complex intersection_of: GO:0000931 ! gamma-tubulin large complex intersection_of: part_of GO:0005816 ! spindle pole body relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0055033 name: gamma-tubulin large complex, interphase microtubule organizing center namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu] synonym: "gamma-tubulin large complex, iMTOC" EXACT [] synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex intersection_of: GO:0000931 ! gamma-tubulin large complex intersection_of: part_of GO:0031021 ! interphase microtubule organizing center relationship: part_of GO:0031021 ! interphase microtubule organizing center [Term] id: GO:0055034 name: Bolwig's organ development namespace: biological_process def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu] is_a: GO:0001654 ! eye development [Term] id: GO:0055035 name: plastid thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jid, GOC:rph] is_a: GO:0042651 ! thylakoid membrane relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0055036 name: virion membrane namespace: cellular_component def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106] subset: goslim_chembl is_a: GO:0016020 ! membrane is_a: GO:0044423 ! virion part [Term] id: GO:0055037 name: recycling endosome namespace: cellular_component def: "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] synonym: "endosomal recycling compartment" EXACT [PMID:20820847] synonym: "endosome recycling compartment" RELATED [GOC:dph, PMID:12370264] synonym: "ERC" RELATED [GOC:dph, PMID:1237064] is_a: GO:0005768 ! endosome [Term] id: GO:0055038 name: recycling endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0055037 ! recycling endosome [Term] id: GO:0055039 name: trichocyst namespace: cellular_component def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jid, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715] xref: Wikipedia:Trichocyst is_a: GO:0043264 ! extracellular non-membrane-bounded organelle [Term] id: GO:0055040 name: periplasmic flagellum namespace: cellular_component def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463] is_a: GO:0009288 ! bacterial-type flagellum relationship: part_of GO:0042597 ! periplasmic space [Term] id: GO:0055041 name: cyclopentanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH." [EC:1.1.1.163, RHEA:11728] synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163] synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163] xref: EC:1.1.1.163 xref: KEGG_REACTION:R02553 xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN xref: RHEA:11728 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0055042 name: 5-valerolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jid, GOC:mlg] is_a: GO:0046573 ! lactonohydrolase activity [Term] id: GO:0055043 name: 5-oxovalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jid, GOC:mlg] is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0055044 name: symplast namespace: cellular_component def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu] subset: goslim_pir xref: Wikipedia:Symplast is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0055045 name: antipodal cell degeneration namespace: biological_process def: "The process in which the antipodal cells undergo programmed cell death." [GOC:mtg_plant] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0055046 name: microgametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant] synonym: "pollen development from the microspore" EXACT systematic_synonym [] xref: Wikipedia:Microgametogenesis is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0055047 name: generative cell mitosis namespace: biological_process def: "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140014 ! mitotic nuclear division relationship: part_of GO:0048232 ! male gamete generation [Term] id: GO:0055048 name: anastral spindle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926] is_a: GO:0051225 ! spindle assembly [Term] id: GO:0055049 name: astral spindle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb] is_a: GO:0051225 ! spindle assembly [Term] id: GO:0055050 name: astral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055049 ! astral spindle assembly intersection_of: GO:0055049 ! astral spindle assembly intersection_of: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0055051 name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding namespace: cellular_component def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex [Term] id: GO:0055052 name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing namespace: cellular_component def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex [Term] id: GO:0055053 name: mannose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct] synonym: "mannose:hydrogen symporter activity" EXACT [] is_a: GO:0009679 ! hexose:proton symporter activity is_a: GO:0015578 ! mannose transmembrane transporter activity [Term] id: GO:0055054 name: fructose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct] synonym: "fructose:hydrogen symporter activity" EXACT [] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0009679 ! hexose:proton symporter activity [Term] id: GO:0055055 name: D-glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct] synonym: "D-glucose:hydrogen symporter activity" EXACT [] is_a: GO:0005356 ! glucose:proton symporter activity is_a: GO:0055056 ! D-glucose transmembrane transporter activity [Term] id: GO:0055056 name: D-glucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:jid, GOC:jsg, GOC:mah] xref: Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region" xref: Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol" xref: Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" is_a: GO:0005355 ! glucose transmembrane transporter activity [Term] id: GO:0055057 name: neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] synonym: "neuroblast cell division" EXACT [] is_a: GO:0036445 ! neuronal stem cell division relationship: part_of GO:0007405 ! neuroblast proliferation [Term] id: GO:0055058 name: symmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph] is_a: GO:0055057 ! neuroblast division [Term] id: GO:0055059 name: asymmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] is_a: GO:0045165 ! cell fate commitment is_a: GO:0055057 ! neuroblast division is_a: GO:0098722 ! asymmetric stem cell division [Term] id: GO:0055060 name: asymmetric neuroblast division resulting in ganglion mother cell formation namespace: biological_process def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph] is_a: GO:0014017 ! neuroblast fate commitment is_a: GO:0055059 ! asymmetric neuroblast division [Term] id: GO:0055061 name: obsolete di-, tri-valent inorganic anion homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] comment: This term was made obsolete because it has been split. synonym: "di-, tri-valent inorganic anion homeostasis" EXACT [] is_obsolete: true consider: GO:0072505 consider: GO:0072506 [Term] id: GO:0055062 name: phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis is_a: GO:0072505 ! divalent inorganic anion homeostasis is_a: GO:0072506 ! trivalent inorganic anion homeostasis [Term] id: GO:0055063 name: sulfate ion homeostasis namespace: biological_process alt_id: GO:0080174 def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah] synonym: "sulfate homeostasis" EXACT [] synonym: "sulphate ion homeostasis" EXACT [] is_a: GO:0072505 ! divalent inorganic anion homeostasis [Term] id: GO:0055064 name: chloride ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0055065 name: metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: goslim_pombe is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis [Term] id: GO:0055066 name: obsolete di-, tri-valent inorganic cation homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] comment: This term was made obsolete because it has been split. synonym: "di-, tri-valent inorganic cation homeostasis" EXACT [] is_obsolete: true consider: GO:0072507 consider: GO:0072508 [Term] id: GO:0055067 name: monovalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis [Term] id: GO:0055068 name: cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0055069 name: zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055070 name: copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "copper homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0055071 name: manganese ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." [GOC:jid, GOC:mah] synonym: "manganese homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0055072 name: iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "iron homeostasis" BROAD [] is_a: GO:0055076 ! transition metal ion homeostasis [Term] id: GO:0055073 name: cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] synonym: "cadmium homeostasis" EXACT [] is_a: GO:0055076 ! transition metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055074 name: calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] synonym: "regulation of calcium ion concentration" EXACT [] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0055075 name: potassium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0055076 name: transition metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732] is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0055077 name: gap junction hemi-channel activity namespace: molecular_function def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh] synonym: "connexon channel activity" EXACT [] is_a: GO:0022829 ! wide pore channel activity relationship: part_of GO:0005243 ! gap junction channel activity [Term] id: GO:0055078 name: sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0055079 name: aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah] synonym: "aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0055080 name: cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055081 name: anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0055082 name: cellular chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0055083 name: monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process alt_id: GO:0090662 def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] is_a: GO:0006810 ! transport created_by: tanyaberardini creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_pombe subset: goslim_yeast synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055087 name: Ski complex namespace: cellular_component def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677] xref: Wikipedia:Ski_complex is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0055088 name: lipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0055089 name: fatty acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055081 ! anion homeostasis is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055090 name: acylglycerol homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl] synonym: "glyceride homeostasis" EXACT [] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055091 name: phospholipid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055081 ! anion homeostasis is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055092 name: sterol homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0055093 name: response to hyperoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv] synonym: "response to hyperoxic stress" EXACT [] synonym: "response to increased oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0036296 ! response to increased oxygen levels [Term] id: GO:0055094 name: response to lipoprotein particle namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:BHF, GOC:rl] synonym: "response to lipoprotein particle stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0055095 name: lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of a lipoprotein particle." [GOC:BHF, GOC:rl] synonym: "lipoprotein mediated signalling" EXACT [] synonym: "lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] synonym: "lipoprotein particle-mediated signaling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071402 ! cellular response to lipoprotein particle stimulus [Term] id: GO:0055096 name: low-density lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of low-density lipoprotein particle." [GOC:BHF, GOC:rl, PMID:16013438] synonym: "low-density lipoprotein mediated signalling" EXACT [] synonym: "low-density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] synonym: "low-density lipoprotein particle-mediated signaling" EXACT [] is_a: GO:0055095 ! lipoprotein particle mediated signaling relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein particle stimulus [Term] id: GO:0055097 name: high density lipoprotein particle mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of high density lipoprotein particle." [GOC:BHF, GOC:rl] synonym: "high density lipoprotein mediated signalling" EXACT [] synonym: "high density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] synonym: "high density lipoprotein particle-mediated signaling" EXACT [] is_a: GO:0055095 ! lipoprotein particle mediated signaling relationship: part_of GO:0071403 ! cellular response to high density lipoprotein particle stimulus [Term] id: GO:0055100 name: adiponectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937] is_a: GO:0005515 ! protein binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0055101 name: obsolete glycerophospholipase inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature. synonym: "glycerophospholipase inhibitor activity" EXACT [] is_obsolete: true [Term] id: GO:0055102 name: lipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0016298 ! lipase activity [Term] id: GO:0055103 name: ligase regulator activity namespace: molecular_function def: "Modulates the activity of a ligase." [GOC:BHF, GOC:rl] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0016874 ! ligase activity [Term] id: GO:0055104 name: ligase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0016874 ! ligase activity [Term] id: GO:0055105 name: ubiquitin-protein transferase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity relationship: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: part_of GO:0031397 ! negative regulation of protein ubiquitination [Term] id: GO:0055106 name: ubiquitin-protein transferase regulator activity namespace: molecular_function def: "Modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0004842 ! ubiquitin-protein transferase activity [Term] id: GO:0055107 name: Golgi to secretory granule transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] is_a: GO:0046907 ! intracellular transport relationship: occurs_in GO:0005737 ! cytoplasm [Term] id: GO:0055108 name: Golgi to transport vesicle transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] is_a: GO:0046907 ! intracellular transport relationship: occurs_in GO:0005737 ! cytoplasm relationship: part_of GO:0048193 ! Golgi vesicle transport [Term] id: GO:0055109 name: invagination involved in gastrulation with mouth forming second namespace: biological_process def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055110 name: involution involved in gastrulation with mouth forming second namespace: biological_process def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055111 name: ingression involved in gastrulation with mouth forming second namespace: biological_process def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0042074 ! cell migration involved in gastrulation intersection_of: GO:0001667 ! ameboidal-type cell migration intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055112 name: delamination involved in gastrulation with mouth forming second namespace: biological_process def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0060232 ! delamination intersection_of: GO:0060232 ! delamination intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055113 name: epiboly involved in gastrulation with mouth forming second namespace: biological_process def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0090504 ! epiboly intersection_of: GO:0090504 ! epiboly intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second relationship: part_of GO:0001702 ! gastrulation with mouth forming second [Term] id: GO:0055114 name: oxidation-reduction process namespace: biological_process def: "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] subset: goslim_pir synonym: "oxidation reduction" EXACT [] synonym: "oxidoreductase process" EXACT systematic_synonym [] xref: Wikipedia:Redox is_a: GO:0008152 ! metabolic process [Term] id: GO:0055115 name: entry into diapause namespace: biological_process def: "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid, GOC:mah] xref: Wikipedia:Diapause is_a: GO:0022611 ! dormancy process [Term] id: GO:0055116 name: entry into reproductive diapause namespace: biological_process def: "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid, GOC:mah] is_a: GO:0055115 ! entry into diapause [Term] id: GO:0055117 name: regulation of cardiac muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060048 ! cardiac muscle contraction relationship: regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0055118 name: negative regulation of cardiac muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0045822 ! negative regulation of heart contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060048 ! cardiac muscle contraction relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0055119 name: relaxation of cardiac muscle namespace: biological_process def: "The process in which the extent of cardiac muscle contraction is reduced." [GOC:ecd] is_a: GO:0090075 ! relaxation of muscle [Term] id: GO:0055120 name: striated muscle dense body namespace: cellular_component def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043292 ! contractile fiber [Term] id: GO:0055121 name: response to high fluence blue light stimulus by blue high-fluence system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red] synonym: "response to high fluence blue light" BROAD [] synonym: "response to high fluence blue light by bhf system" RELATED [] is_a: GO:0009637 ! response to blue light is_a: GO:0009644 ! response to high light intensity [Term] id: GO:0055122 name: response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0055123 name: digestive system development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] is_a: GO:0048731 ! system development [Term] id: GO:0055124 name: obsolete premature neural plate formation namespace: biological_process def: "OBSOLETE. The formation of the neural plate before the appropriate time." [GOC:jid] synonym: "premature neural plate formation" EXACT [] is_obsolete: true [Term] id: GO:0055125 name: obsolete Nic96 complex namespace: cellular_component def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174] synonym: "Nic96 complex" EXACT [] is_obsolete: true consider: GO:0044612 created_by: Jennifer I Deegan creation_date: 2009-10-12T08:35:18Z [Term] id: GO:0055126 name: obsolete Nup82 complex namespace: cellular_component def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174] synonym: "Nup82 complex" EXACT [] is_obsolete: true consider: GO:0044612 created_by: Jennifer I Deegan creation_date: 2009-10-12T08:35:34Z [Term] id: GO:0055127 name: vibrational conductance of sound to the inner ear namespace: biological_process def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007605 ! sensory perception of sound created_by: Jennifer I Deegan creation_date: 2009-10-13T10:59:39Z [Term] id: GO:0055129 name: L-proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD [] is_a: GO:0006561 ! proline biosynthetic process is_a: GO:0017144 ! drug metabolic process created_by: Jennifer I Deegan creation_date: 2009-10-22T01:59:56Z [Term] id: GO:0055130 name: D-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd] synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046436 ! D-alanine metabolic process created_by: Jennifer I Deegan creation_date: 2009-10-22T02:02:42Z [Term] id: GO:0055131 name: C3HC4-type RING finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957] is_a: GO:0019904 ! protein domain specific binding created_by: Jennifer I Deegan creation_date: 2009-10-22T02:20:33Z [Term] id: GO:0060001 name: minus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph] is_a: GO:0000146 ! microfilament motor activity [Term] id: GO:0060002 name: plus-end directed microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557] synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph] synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph] synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph] is_a: GO:0000146 ! microfilament motor activity [Term] id: GO:0060003 name: copper ion export namespace: biological_process def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph] synonym: "copper export" EXACT [GOC:dph] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0060004 name: reflex namespace: biological_process def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:0877797099] xref: Wikipedia:Reflex is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0060005 name: vestibular reflex namespace: biological_process def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757] is_a: GO:0060004 ! reflex [Term] id: GO:0060006 name: angular vestibuloocular reflex namespace: biological_process def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] is_a: GO:0060005 ! vestibular reflex [Term] id: GO:0060007 name: linear vestibuloocular reflex namespace: biological_process def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] is_a: GO:0060005 ! vestibular reflex [Term] id: GO:0060008 name: Sertoli cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0060009 name: Sertoli cell development namespace: biological_process def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph] is_a: GO:0002064 ! epithelial cell development is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0060008 ! Sertoli cell differentiation [Term] id: GO:0060010 name: Sertoli cell fate commitment namespace: biological_process def: "The process in which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0060008 ! Sertoli cell differentiation [Term] id: GO:0060011 name: Sertoli cell proliferation namespace: biological_process def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0008584 ! male gonad development [Term] id: GO:0060012 name: synaptic transmission, glycinergic namespace: biological_process def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] synonym: "glycinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0060013 name: righting reflex namespace: biological_process def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460] synonym: "righting response" EXACT [GOC:dph] is_a: GO:0060004 ! reflex [Term] id: GO:0060014 name: granulosa cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0060015 name: granulosa cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0060014 ! granulosa cell differentiation [Term] id: GO:0060016 name: granulosa cell development namespace: biological_process def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0060014 ! granulosa cell differentiation [Term] id: GO:0060017 name: parathyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0060018 name: astrocyte fate commitment namespace: biological_process def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph] is_a: GO:0021781 ! glial cell fate commitment relationship: part_of GO:0048708 ! astrocyte differentiation [Term] id: GO:0060019 name: radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] is_a: GO:0010001 ! glial cell differentiation [Term] id: GO:0060020 name: Bergmann glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] is_a: GO:0048708 ! astrocyte differentiation [Term] id: GO:0060021 name: roof of mouth development namespace: biological_process def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544] synonym: "palatum development" EXACT [ISBN:0721662544] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060022 name: hard palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544] synonym: "palatum durum development" EXACT [ISBN:0721662544] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0062009 ! secondary palate development [Term] id: GO:0060023 name: soft palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544] synonym: "palatum molle development" EXACT [ISBN:0721662544] synonym: "velum palatum development" EXACT [ISBN:0721662544] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0062009 ! secondary palate development [Term] id: GO:0060024 name: rhythmic synaptic transmission namespace: biological_process def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph] is_a: GO:0050804 ! modulation of chemical synaptic transmission [Term] id: GO:0060025 name: regulation of synaptic activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] is_a: GO:0050804 ! modulation of chemical synaptic transmission relationship: part_of GO:0050803 ! regulation of synapse structure or activity [Term] id: GO:0060026 name: convergent extension namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082] xref: Wikipedia:Convergent_extension is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0060027 name: convergent extension involved in gastrulation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0060028 name: convergent extension involved in axis elongation namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0003401 ! axis elongation relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0060029 name: convergent extension involved in organogenesis namespace: biological_process def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082] is_a: GO:0060026 ! convergent extension intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0048513 ! animal organ development relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0060030 name: dorsal convergence namespace: biological_process def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:dgf, GOC:dph, PMID:12062082] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0060027 ! convergent extension involved in gastrulation [Term] id: GO:0060031 name: mediolateral intercalation namespace: biological_process def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0060027 ! convergent extension involved in gastrulation [Term] id: GO:0060032 name: notochord regression namespace: biological_process def: "The developmental process in which the stucture of the notochord is destroyed in an embryo." [GOC:dph] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0048570 ! notochord morphogenesis [Term] id: GO:0060033 name: anatomical structure regression namespace: biological_process def: "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph] synonym: "histolysis" RELATED [GOC:mtg_apoptosis] synonym: "tissue death" RELATED [GOC:mtg_apoptosis] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0060034 name: notochord cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030903 ! notochord development [Term] id: GO:0060035 name: notochord cell development namespace: biological_process def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0060034 ! notochord cell differentiation [Term] id: GO:0060036 name: notochord cell vacuolation namespace: biological_process def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477] is_a: GO:0007033 ! vacuole organization relationship: part_of GO:0060035 ! notochord cell development [Term] id: GO:0060037 name: pharyngeal system development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] is_a: GO:0048731 ! system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0060038 name: cardiac muscle cell proliferation namespace: biological_process def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] synonym: "cardiac myocyte proliferation" EXACT [] synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] synonym: "heart muscle cell proliferation" EXACT [] is_a: GO:0014855 ! striated muscle cell proliferation relationship: part_of GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0060039 name: pericardium development namespace: biological_process def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060040 name: retinal bipolar neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:1905962 ! glutamatergic neuron differentiation relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060041 name: retina development in camera-type eye namespace: biological_process alt_id: GO:0002073 def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] synonym: "retina development in camera-style eye" EXACT [] synonym: "retinal development" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0060042 name: retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] synonym: "retina morphogenesis in camera-style eye" EXACT [] synonym: "retinogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0060043 name: regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] synonym: "regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060038 ! cardiac muscle cell proliferation relationship: regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060044 name: negative regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "negative regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060045 name: positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "positive regulation of heart muscle cell proliferation" RELATED [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060038 ! cardiac muscle cell proliferation relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation [Term] id: GO:0060046 name: regulation of acrosome reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph] is_a: GO:0080154 ! regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007340 ! acrosome reaction relationship: regulates GO:0007340 ! acrosome reaction [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0060048 name: cardiac muscle contraction namespace: biological_process def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] synonym: "heart muscle contraction" EXACT [] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0060047 ! heart contraction [Term] id: GO:0060049 name: regulation of protein glycosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006486 ! protein glycosylation relationship: regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060050 name: positive regulation of protein glycosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006486 ! protein glycosylation relationship: positively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060051 name: negative regulation of protein glycosylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006486 ! protein glycosylation relationship: negatively_regulates GO:0006486 ! protein glycosylation [Term] id: GO:0060052 name: neurofilament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph] synonym: "neurofilament cytoskeleton organisation" EXACT [GOC:mah] synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045104 ! intermediate filament cytoskeleton organization [Term] id: GO:0060053 name: neurofilament cytoskeleton namespace: cellular_component def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph] is_a: GO:0045111 ! intermediate filament cytoskeleton relationship: has_part GO:0005883 ! neurofilament [Term] id: GO:0060054 name: positive regulation of epithelial cell proliferation involved in wound healing namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060055 name: angiogenesis involved in wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0060056 name: mammary gland involution namespace: biological_process def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0060443 ! mammary gland morphogenesis [Term] id: GO:0060057 name: apoptotic process involved in mammary gland involution namespace: biological_process def: "Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in mammary gland involution" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0060056 ! mammary gland involution relationship: part_of GO:0060056 ! mammary gland involution [Term] id: GO:0060058 name: positive regulation of apoptotic process involved in mammary gland involution namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution." [GOC:dph, GOC:mtg_apoptosis, PMID:15282149] synonym: "positive regulation of apoptosis involved in mammary gland involution" NARROW [] is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis is_a: GO:1903521 ! positive regulation of mammary gland involution intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution relationship: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution [Term] id: GO:0060059 name: embryonic retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage." [GOC:dgh, GOC:dph] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060060 name: post-embryonic retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage." [GOC:dgh, GOC:dph] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060061 name: Spemann organizer formation namespace: biological_process def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph] synonym: "Spemann's organizer formation" EXACT [] synonym: "Spemann-Mangold organizer formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0031128 ! developmental induction [Term] id: GO:0060062 name: Spemann organizer formation at the dorsal lip of the blastopore namespace: biological_process def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883] comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT [] synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060063 name: Spemann organizer formation at the embryonic shield namespace: biological_process def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883] comment: Occurs in Teleost fish. synonym: "Spemann's organizer formation at the embryonic shield" EXACT [] synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060064 name: Spemann organizer formation at the anterior end of the primitive streak namespace: biological_process def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883] comment: Occurs in reptiles, birds and mammals. synonym: "Spemann organizer formation in amniotes" RELATED [] synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT [] synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED [] is_a: GO:0060061 ! Spemann organizer formation [Term] id: GO:0060065 name: uterus development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060066 name: oviduct development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct] synonym: "fallopian tube development" NARROW [GOC:bf] synonym: "Mullerian tract development" RELATED [] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060067 name: cervix development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] synonym: "Mullerian tract development" RELATED [] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0060068 name: vagina development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] is_a: GO:0030540 ! female genitalia development [Term] id: GO:0060069 name: Wnt signaling pathway, regulating spindle positioning namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397] synonym: "non-canonical Wnt signaling pathway" BROAD [] synonym: "Wnt receptor signaling pathway, regulating spindle positioning" EXACT [] synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT [] synonym: "Wnt-activated signaling pathway, regulating spindle positioning" EXACT [GOC:signaling] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0035567 ! non-canonical Wnt signaling pathway is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: regulates GO:0040001 ! establishment of mitotic spindle localization relationship: regulates GO:0040001 ! establishment of mitotic spindle localization [Term] id: GO:0060070 name: canonical Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "frizzled-1 receptor signaling pathway" NARROW [] synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT [] synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT [] is_a: GO:0016055 ! Wnt signaling pathway [Term] id: GO:0060071 name: Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf] synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "planar cell polarity pathway" EXACT [GOC:cjm] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf] synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph] is_a: GO:0035567 ! non-canonical Wnt signaling pathway is_a: GO:0090175 ! regulation of establishment of planar polarity [Term] id: GO:0060072 name: large conductance calcium-activated potassium channel activity namespace: molecular_function alt_id: GO:0022895 def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074] synonym: "BK calcium-activated potassium channel activity" EXACT [] synonym: "BK channel activity" RELATED [] synonym: "BK KCa channels" EXACT [] synonym: "large conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0060073 name: micturition namespace: biological_process def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] synonym: "urination" EXACT [] synonym: "urine voiding" EXACT [] xref: Wikipedia:Urination is_a: GO:0003014 ! renal system process is_a: GO:0007588 ! excretion [Term] id: GO:0060074 name: synapse maturation namespace: biological_process def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef] subset: goslim_synapse synonym: "synaptic maturation" EXACT [] is_a: GO:0021700 ! developmental maturation is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0060075 name: regulation of resting membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433] synonym: "regulation of resting potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060076 name: excitatory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: Wikipedia:Excitatory_synapse is_a: GO:0045202 ! synapse disjoint_from: GO:0060077 ! inhibitory synapse [Term] id: GO:0060077 name: inhibitory synapse namespace: cellular_component def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] xref: Wikipedia:Inhibitory_postsynaptic_potential is_a: GO:0045202 ! synapse [Term] id: GO:0060078 name: regulation of postsynaptic membrane potential namespace: biological_process def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef] subset: goslim_synapse synonym: "regulation of post-synaptic membrane potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060079 name: excitatory postsynaptic potential namespace: biological_process def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] synonym: "regulation of EPSP" RELATED [] synonym: "regulation of excitatory post-synaptic membrane potential" EXACT [] is_a: GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic [Term] id: GO:0060080 name: inhibitory postsynaptic potential namespace: biological_process def: "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef] synonym: "IPSP" RELATED [] synonym: "regulation of inhibitory post-synaptic membrane potential" EXACT [] is_a: GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic [Term] id: GO:0060081 name: membrane hyperpolarization namespace: biological_process def: "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential." [GOC:dph] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0060082 name: eye blink reflex namespace: biological_process def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208] synonym: "nictitating membrane reflex" EXACT [] is_a: GO:0060004 ! reflex [Term] id: GO:0060083 name: smooth muscle contraction involved in micturition namespace: biological_process def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347] synonym: "smooth muscle contraction involved in urination" RELATED [] synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph] is_a: GO:0014832 ! urinary bladder smooth muscle contraction intersection_of: GO:0006939 ! smooth muscle contraction intersection_of: part_of GO:0060073 ! micturition relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060084 name: synaptic transmission involved in micturition namespace: biological_process def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] synonym: "synaptic transmission involved in urination" RELATED [] is_a: GO:0007274 ! neuromuscular synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: part_of GO:0060073 ! micturition relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060085 name: smooth muscle relaxation of the bladder outlet namespace: biological_process def: "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] synonym: "synaptic transmission involved in urination" EXACT [] is_a: GO:0044557 ! relaxation of smooth muscle is_a: GO:0045986 ! negative regulation of smooth muscle contraction relationship: part_of GO:0060073 ! micturition [Term] id: GO:0060086 name: circadian temperature homeostasis namespace: biological_process def: "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb] synonym: "circadian regulation of body temperature" RELATED [] synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb] is_a: GO:0001659 ! temperature homeostasis is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0060087 name: relaxation of vascular smooth muscle namespace: biological_process alt_id: GO:1905657 alt_id: GO:1905658 alt_id: GO:1905659 def: "A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411] synonym: "negative regulation of relaxation of vascular smooth muscle" RELATED [] synonym: "positive regulation of relaxation of vascular smooth muscle" RELATED [] synonym: "regulation of relaxation of vascular smooth muscle" RELATED [] synonym: "vascular smooth muscle relaxation" EXACT [] is_a: GO:0044557 ! relaxation of smooth muscle is_a: GO:0045986 ! negative regulation of smooth muscle contraction relationship: part_of GO:0042311 ! vasodilation [Term] id: GO:0060088 name: auditory receptor cell stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835] synonym: "auditory receptor cell stereocilium organisation" EXACT [] synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0060122 ! inner ear receptor cell stereocilium organization relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis [Term] id: GO:0060089 name: molecular transducer activity namespace: molecular_function def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt] subset: gocheck_do_not_manually_annotate subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0060090 name: molecular adaptor activity namespace: molecular_function alt_id: GO:0032947 def: "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] subset: goslim_drosophila subset: goslim_pir synonym: "binding, bridging" EXACT [] synonym: "protein complex scaffold activity" RELATED [] synonym: "protein-containing complex scaffold activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0060091 name: kinocilium namespace: cellular_component def: "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:cilia, GOC:dph, PMID:15882574] xref: Wikipedia:Kinocilium is_a: GO:0043005 ! neuron projection is_a: GO:0097732 ! 9+2 non-motile cilium relationship: part_of GO:0032421 ! stereocilium bundle relationship: part_of GO:0043226 ! organelle [Term] id: GO:0060092 name: regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060012 ! synaptic transmission, glycinergic relationship: regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060093 name: negative regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060094 name: positive regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060012 ! synaptic transmission, glycinergic relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic [Term] id: GO:0060095 name: zinc potentiation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT [] is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic [Term] id: GO:0060096 name: serotonin secretion, neurotransmission namespace: biological_process def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph] synonym: "serotonin release, neurotransmission" RELATED [GOC:tb] is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion [Term] id: GO:0060097 name: cytoskeletal rearrangement involved in phagocytosis, engulfment namespace: biological_process def: "The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0007010 ! cytoskeleton organization intersection_of: part_of GO:0006911 ! phagocytosis, engulfment relationship: part_of GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060098 name: membrane reorganization involved in phagocytosis, engulfment namespace: biological_process def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] synonym: "membrane reorganisation involved in phagocytosis, engulfment" EXACT [GOC:mah] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060099 name: regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006911 ! phagocytosis, engulfment relationship: regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060100 name: positive regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0060099 ! regulation of phagocytosis, engulfment is_a: GO:1905155 ! positive regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006911 ! phagocytosis, engulfment relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060101 name: negative regulation of phagocytosis, engulfment namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:0060099 ! regulation of phagocytosis, engulfment is_a: GO:1905154 ! negative regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006911 ! phagocytosis, engulfment relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment [Term] id: GO:0060102 name: collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0060103 name: obsolete collagen and cuticulin-based cuticle extracellular matrix part namespace: cellular_component def: "OBSOLETE. Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: GO:0060102 [Term] id: GO:0060104 name: surface coat of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060105 name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060106 name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060107 name: annuli extracellular matrix namespace: cellular_component def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "annulae" RELATED [] synonym: "annular rings" RELATED [] synonym: "annule(s)" RELATED [] synonym: "annulus" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060108 name: annular furrow extracellular matrix namespace: cellular_component def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060109 name: medial layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "medial layer struts" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060110 name: basal layer of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060111 name: alae of collagen and cuticulin-based cuticle extracellular matrix namespace: cellular_component def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507] synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix [Term] id: GO:0060112 name: generation of ovulation cycle rhythm namespace: biological_process def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph] synonym: "generation of estrus cycle rhythm" EXACT [] synonym: "generation of menstrual cycle rhythm" RELATED [] synonym: "generation of oestrus cycle rhythm" EXACT [] is_a: GO:0022602 ! ovulation cycle process [Term] id: GO:0060113 name: inner ear receptor cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph] synonym: "inner ear hair cell differentiation" EXACT [] is_a: GO:0042490 ! mechanoreceptor differentiation relationship: part_of GO:0048839 ! inner ear development [Term] id: GO:0060114 name: vestibular receptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph] synonym: "vestibular hair cell differentiation" EXACT [] is_a: GO:0035315 ! hair cell differentiation is_a: GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060115 name: vestibular receptor cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a vestibular receptor cell." [GOC:dph] synonym: "vestibular hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment relationship: part_of GO:0060114 ! vestibular receptor cell differentiation [Term] id: GO:0060116 name: vestibular receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb] synonym: "vestibular hair cell morphogenesis" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060118 ! vestibular receptor cell development [Term] id: GO:0060117 name: auditory receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "auditory hair cell development" EXACT [] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development is_a: GO:0060119 ! inner ear receptor cell development relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0060118 name: vestibular receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "vestibular hair cell development" EXACT [] is_a: GO:0060119 ! inner ear receptor cell development relationship: part_of GO:0060114 ! vestibular receptor cell differentiation [Term] id: GO:0060119 name: inner ear receptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] synonym: "inner ear hair cell development" EXACT [] is_a: GO:0048666 ! neuron development relationship: part_of GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060120 name: inner ear receptor cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become an inner ear receptor cell." [GOC:dph] synonym: "inner ear hair cell fate commitment" EXACT [] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0060113 ! inner ear receptor cell differentiation [Term] id: GO:0060121 name: vestibular receptor cell stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph] synonym: "vestibular hair cell stereocilium organization" EXACT [] synonym: "vestibular receptor cell stereocilium organisation" EXACT [GOC:mah] synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0060122 ! inner ear receptor cell stereocilium organization is_a: GO:0106027 ! neuron projection organization relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis [Term] id: GO:0060122 name: inner ear receptor cell stereocilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph] synonym: "inner ear hair cell receptor stereocilium organization" EXACT [] synonym: "inner ear receptor stereocilium organisation" EXACT [GOC:mah] synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031175 ! neuron projection development relationship: part_of GO:0060119 ! inner ear receptor cell development [Term] id: GO:0060123 name: regulation of growth hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030252 ! growth hormone secretion relationship: regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060124 name: positive regulation of growth hormone secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030252 ! growth hormone secretion relationship: positively_regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060125 name: negative regulation of growth hormone secretion namespace: biological_process def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030252 ! growth hormone secretion relationship: negatively_regulates GO:0030252 ! growth hormone secretion [Term] id: GO:0060126 name: somatotropin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell differentiation" EXACT [] synonym: "somatotrope differentiation" RELATED [] synonym: "somatotroph differentiation" RELATED [] synonym: "somatotrophin secreting cell differentiation" EXACT [] synonym: "somatotropic cell differentiation" RELATED [] synonym: "somatrophic cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060127 name: prolactin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil differentiation" EXACT [] synonym: "lactotrope differentiation" EXACT [] synonym: "lactotroph differentiation" EXACT [] synonym: "lactotropic cell differentiation" EXACT [] synonym: "mammotrope differentiation" EXACT [] synonym: "mammotroph differentiation" EXACT [] synonym: "mammotrophic cell differentiation" EXACT [] synonym: "mammotropic cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060128 name: corticotropin hormone secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] synonym: "corticotrope differentiation" EXACT [] synonym: "corticotroph differentiation" EXACT [] synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060129 name: thyroid-stimulating hormone-secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil differentiation" EXACT [] synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT [] synonym: "thyrotrope differentiation" EXACT [] synonym: "thyrotroph differentiation" EXACT [] synonym: "TSH-secreting cell differentiation" EXACT [] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0021984 ! adenohypophysis development [Term] id: GO:0060130 name: thyroid-stimulating hormone-secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] synonym: "beta-basophil development" EXACT [] synonym: "thyroid stimulating hormone secreting cell development" EXACT [] synonym: "thyrotrope development" EXACT [] synonym: "thyrotroph development" EXACT [] synonym: "TSH-secreting cell development" EXACT [] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0060129 ! thyroid-stimulating hormone-secreting cell differentiation [Term] id: GO:0060131 name: corticotropin hormone secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] synonym: "corticotrope development" EXACT [] synonym: "corticotroph development" RELATED [] synonym: "corticotrophin hormone secreting cell development" RELATED [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060128 ! corticotropin hormone secreting cell differentiation [Term] id: GO:0060132 name: prolactin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil development" EXACT [] synonym: "lactotrope development" EXACT [] synonym: "lactotroph development" EXACT [] synonym: "lactotropic cell development" EXACT [] synonym: "mammotrope development" EXACT [] synonym: "mammotroph development" EXACT [] synonym: "mammotrophic cell development" EXACT [] synonym: "mammotropic cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060127 ! prolactin secreting cell differentiation [Term] id: GO:0060133 name: somatotropin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell development" EXACT [] synonym: "somatotrope development" RELATED [] synonym: "somatotroph development" RELATED [] synonym: "somatotrophin secreting cell development" EXACT [] synonym: "somatotropic cell development" EXACT [] synonym: "somatrophic cell development" RELATED [] is_a: GO:0048468 ! cell development relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation [Term] id: GO:0060134 name: prepulse inhibition namespace: biological_process def: "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260] synonym: "PPI" RELATED [] synonym: "pre-pulse inhibition" EXACT [] xref: Wikipedia:Prepulse_inhibition is_a: GO:0032102 ! negative regulation of response to external stimulus relationship: part_of GO:0001964 ! startle response [Term] id: GO:0060135 name: maternal process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0060136 name: embryonic process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: part_of GO:0007565 ! female pregnancy intersection_of: part_of GO:0009790 ! embryo development relationship: part_of GO:0007565 ! female pregnancy relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0060137 name: maternal process involved in parturition namespace: biological_process def: "A reproductive process occurring in the mother that results in birth." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007567 ! parturition [Term] id: GO:0060138 name: fetal process involved in parturition namespace: biological_process def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007567 ! parturition relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0060139 name: positive regulation of apoptotic process by virus namespace: biological_process def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:dph, GOC:mtg_apoptosis] synonym: "positive regulation of apoptosis by virus" NARROW [] is_a: GO:0039526 ! modulation by virus of host apoptotic process is_a: GO:0052151 ! positive regulation by symbiont of host apoptotic process intersection_of: GO:0019048 ! modulation by virus of host morphology or physiology intersection_of: positively_regulates GO:0006915 ! apoptotic process [Term] id: GO:0060140 name: modulation by virus of syncytium formation via plasma membrane fusion namespace: biological_process def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion [Term] id: GO:0060141 name: positive regulation of syncytium formation by virus namespace: biological_process def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] synonym: "syncytium formation induced by viral infection" EXACT [UniProtKB-KW:KW-1180] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0060140 ! modulation by virus of syncytium formation via plasma membrane fusion is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion [Term] id: GO:0060142 name: regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000768 ! syncytium formation by plasma membrane fusion relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0060143 name: positive regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion [Term] id: GO:0060144 name: host cellular process involved in virus induced gene silencing namespace: biological_process def: "A cellular process occurring in the host cell that contributes to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph] is_a: GO:0051702 ! interaction with symbiont relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060145 name: viral gene silencing in virus induced gene silencing namespace: biological_process def: "The posttranscriptional gene silencing of viral genes after viral infection." [GOC:dph] is_a: GO:0016441 ! posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060146 name: host gene silencing in virus induced gene silencing namespace: biological_process def: "The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph] is_a: GO:0016441 ! posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060147 name: regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016441 ! posttranscriptional gene silencing relationship: regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060148 name: positive regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060147 ! regulation of posttranscriptional gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016441 ! posttranscriptional gene silencing relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060149 name: negative regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060969 ! negative regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016441 ! posttranscriptional gene silencing relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0060150 name: viral triggering of virus induced gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression of both viral genes and host homologues to those genes by a posttranscriptional mechanism in a virally infected cell." [GOC:dph] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing relationship: part_of GO:0009616 ! virus induced gene silencing [Term] id: GO:0060151 name: peroxisome localization namespace: biological_process def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] synonym: "peroxisome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0060152 name: microtubule-based peroxisome localization namespace: biological_process def: "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] synonym: "microtubule-based peroxisome localisation" EXACT [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0060151 ! peroxisome localization [Term] id: GO:0060153 name: modulation by virus of host cell cycle namespace: biological_process def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph, UniProtKB-KW:KW-1121, VZ:1636] synonym: "modulation of host cell cycle by virus" EXACT [UniProtKB-KW:KW-1121] synonym: "regulation by virus of host cell cycle" EXACT [] synonym: "regulation of host cell cycle by virus" EXACT [] synonym: "viral process regulating host cell cycle" EXACT [] xref: VZ:1636 "Modulation of host cell cycle by virus" is_a: GO:0019055 ! modification by virus of host cell cycle regulation [Term] id: GO:0060154 name: obsolete cellular process regulating host cell cycle in response to virus namespace: biological_process def: "OBSOLETE. Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph] comment: The reason for obsoletion is that based on the definition, it is not clear that this process exists. is_obsolete: true [Term] id: GO:0060155 name: platelet dense granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378] synonym: "bull's eye body organization and biogenesis" RELATED [] synonym: "platelet dense body organization and biogenesis" RELATED [] synonym: "platelet dense granule organisation" EXACT [GOC:mah] synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033363 ! secretory granule organization [Term] id: GO:0060156 name: milk ejection reflex namespace: biological_process def: "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:cjm, GOC:dph, GOC:mr, GOC:st] synonym: "milk ejection" EXACT [] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue is_a: GO:0060004 ! reflex relationship: part_of GO:0007595 ! lactation [Term] id: GO:0060157 name: urinary bladder development namespace: biological_process def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, http://en.wikipedia.org/wiki/Rhea_(bird), PMID:11768524, PMID:18276178, PMID:538956] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0060158 name: phospholipase C-activating dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914] synonym: "activation of phospholipase C activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" RELATED [GOC:mah] synonym: "dopamine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060159 name: regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007212 ! dopamine receptor signaling pathway relationship: regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060160 name: negative regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway is_a: GO:2001039 ! negative regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060161 name: positive regulation of dopamine receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway is_a: GO:2001040 ! positive regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007212 ! dopamine receptor signaling pathway relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0060162 name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423] synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway is_a: GO:1900737 ! negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway relationship: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway [Term] id: GO:0060163 name: subpallium neuron fate commitment namespace: biological_process def: "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] synonym: "subpallium neuronal precursor fate commitment" RELATED [] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0060164 name: regulation of timing of neuron differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0048505 ! regulation of timing of cell differentiation [Term] id: GO:0060165 name: regulation of timing of subpallium neuron differentiation namespace: biological_process def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] is_a: GO:0060164 ! regulation of timing of neuron differentiation relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0060166 name: olfactory pit development namespace: biological_process def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043584 ! nose development [Term] id: GO:0060167 name: regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001973 ! adenosine receptor signaling pathway relationship: regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060168 name: positive regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001973 ! adenosine receptor signaling pathway relationship: positively_regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060169 name: negative regulation of adenosine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway relationship: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway [Term] id: GO:0060170 name: ciliary membrane namespace: cellular_component alt_id: GO:0020017 def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial membrane" EXACT [] synonym: "cilium membrane" EXACT [] synonym: "flagellar membrane" NARROW [] synonym: "flagellum membrane" NARROW [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005929 ! cilium [Term] id: GO:0060171 name: stereocilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph] is_a: GO:0032589 ! neuron projection membrane relationship: part_of GO:0005622 ! intracellular relationship: part_of GO:0032420 ! stereocilium [Term] id: GO:0060172 name: astral microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0030953 ! astral microtubule organization [Term] id: GO:0060173 name: limb development namespace: biological_process def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] synonym: "limb bud development" NARROW [GOC:dph] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development [Term] id: GO:0060174 name: limb bud formation namespace: biological_process def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph] synonym: "limb formation" EXACT [] synonym: "limbbud formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035108 ! limb morphogenesis [Term] id: GO:0060175 name: brain-derived neurotrophic factor-activated receptor activity namespace: molecular_function def: "Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:dph] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand BDNF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "BDNF receptor activity" RELATED [GOC:dph] synonym: "BDNF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0005030 ! neurotrophin receptor activity relationship: has_part GO:0048403 ! brain-derived neurotrophic factor binding relationship: part_of GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0060176 name: regulation of aggregation involved in sorocarp development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0031156 ! regulation of sorocarp development is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031152 ! aggregation involved in sorocarp development relationship: regulates GO:0031152 ! aggregation involved in sorocarp development [Term] id: GO:0060177 name: regulation of angiotensin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb] synonym: "regulation of angiotensin metabolism" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process [Term] id: GO:0060178 name: regulation of exocyst localization namespace: biological_process def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:dph, GOC:tb] synonym: "regulation of exocyst localisation" EXACT [GOC:mah] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051601 ! exocyst localization relationship: regulates GO:0051601 ! exocyst localization [Term] id: GO:0060179 name: male mating behavior namespace: biological_process def: "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] is_a: GO:0007617 ! mating behavior [Term] id: GO:0060180 name: female mating behavior namespace: biological_process def: "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] is_a: GO:0007617 ! mating behavior [Term] id: GO:0060182 name: apelin receptor activity namespace: molecular_function def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: part_of GO:0060183 ! apelin receptor signaling pathway [Term] id: GO:0060183 name: apelin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph] synonym: "apelin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0060184 name: cell cycle switching namespace: biological_process def: "The process in which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0060185 name: outer ear unfolding namespace: biological_process def: "The opening and spreading out of the outer ear." [GOC:dph] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0042473 ! outer ear morphogenesis [Term] id: GO:0060186 name: outer ear emergence namespace: biological_process def: "The growth of the outer ear." [GOC:dph] synonym: "ear elevation" RELATED [GOC:dph] synonym: "ear extroversion" RELATED [GOC:dph] synonym: "outer ear growth" RELATED [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0042473 ! outer ear morphogenesis [Term] id: GO:0060187 name: cell pole namespace: cellular_component def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] comment: Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal. is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0060188 name: regulation of protein desumoylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016926 ! protein desumoylation relationship: regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060189 name: positive regulation of protein desumoylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0060188 ! regulation of protein desumoylation is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016926 ! protein desumoylation relationship: positively_regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060190 name: negative regulation of protein desumoylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0060188 ! regulation of protein desumoylation is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016926 ! protein desumoylation relationship: negatively_regulates GO:0016926 ! protein desumoylation [Term] id: GO:0060191 name: regulation of lipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016298 ! lipase activity relationship: regulates GO:0016298 ! lipase activity [Term] id: GO:0060192 name: negative regulation of lipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0060191 ! regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016298 ! lipase activity relationship: negatively_regulates GO:0016298 ! lipase activity [Term] id: GO:0060193 name: positive regulation of lipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0060191 ! regulation of lipase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016298 ! lipase activity relationship: positively_regulates GO:0016298 ! lipase activity [Term] id: GO:0060194 name: regulation of antisense RNA transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009300 ! antisense RNA transcription relationship: regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060195 name: negative regulation of antisense RNA transcription namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0060194 ! regulation of antisense RNA transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009300 ! antisense RNA transcription relationship: negatively_regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060196 name: positive regulation of antisense RNA transcription namespace: biological_process def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0060194 ! regulation of antisense RNA transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009300 ! antisense RNA transcription relationship: positively_regulates GO:0009300 ! antisense RNA transcription [Term] id: GO:0060197 name: cloacal septation namespace: biological_process def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st] synonym: "cloaca septation" EXACT [GOC:cjm] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0035844 ! cloaca development [Term] id: GO:0060198 name: clathrin-sculpted vesicle namespace: cellular_component def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph] synonym: "clathrin sculpted vesicle" EXACT [GOC:sl] is_a: GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0060199 name: clathrin-sculpted glutamate transport vesicle namespace: cellular_component def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph] synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle" EXACT [] synonym: "clathrin sculpted glutamate transport vesicle" EXACT [GOC:sl] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin-sculpted vesicle [Term] id: GO:0060200 name: clathrin-sculpted acetylcholine transport vesicle namespace: cellular_component def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph] synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle" EXACT [] synonym: "clathrin sculpted acetylcholine transport vesicle" EXACT [GOC:sl] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin-sculpted vesicle [Term] id: GO:0060201 name: clathrin-sculpted acetylcholine transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle." [GOC:dph] synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "clathrin sculpted acetylcholine transport vesicle membrane" EXACT [GOC:sl] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle [Term] id: GO:0060202 name: clathrin-sculpted acetylcholine transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle." [GOC:dph] synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen" EXACT [] synonym: "clathrin sculpted acetylcholine transport vesicle lumen" EXACT [GOC:sl] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle [Term] id: GO:0060203 name: clathrin-sculpted glutamate transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle." [GOC:dph] synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "clathrin sculpted glutamate transport vesicle membrane" EXACT [GOC:sl] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle [Term] id: GO:0060204 name: clathrin-sculpted glutamate transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle." [GOC:dph] synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen" EXACT [] synonym: "clathrin sculpted glutamate transport vesicle lumen" EXACT [GOC:sl] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle [Term] id: GO:0060205 name: cytoplasmic vesicle lumen namespace: cellular_component def: "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] synonym: "cytoplasmic membrane-bounded vesicle lumen" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle lumen" RELATED [] is_a: GO:0031983 ! vesicle lumen is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0060206 name: estrous cycle phase namespace: biological_process def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0060207 name: diestrus namespace: biological_process def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544] subset: gocheck_do_not_annotate is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060208 name: proestrus namespace: biological_process def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544] subset: gocheck_do_not_annotate is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060209 name: estrus namespace: biological_process def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544] subset: gocheck_do_not_annotate synonym: "oestrus" EXACT [] is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060210 name: metestrus namespace: biological_process def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544] subset: gocheck_do_not_annotate is_a: GO:0060206 ! estrous cycle phase [Term] id: GO:0060211 name: regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED [] synonym: "regulation of mRNA deadenylation" RELATED [] synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060212 name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060213 name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening is_a: GO:1900153 ! positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening [Term] id: GO:0060214 name: endocardium formation namespace: biological_process def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003160 ! endocardium morphogenesis [Term] id: GO:0060215 name: primitive hemopoiesis namespace: biological_process def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] synonym: "primitive haematopoiesis" EXACT [] synonym: "primitive haemopoiesis" EXACT [] synonym: "primitive hematopoiesis" RELATED [] is_a: GO:0035162 ! embryonic hemopoiesis [Term] id: GO:0060216 name: definitive hemopoiesis namespace: biological_process def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] synonym: "definitive haematopoiesis" RELATED [] synonym: "definitive haemopoiesis" EXACT [] synonym: "definitive hematopoiesis" EXACT [] is_a: GO:0030097 ! hemopoiesis [Term] id: GO:0060217 name: hemangioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018] is_a: GO:0048333 ! mesodermal cell differentiation relationship: part_of GO:0060215 ! primitive hemopoiesis [Term] id: GO:0060218 name: hematopoietic stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] synonym: "haematopoietic stem cell differentiation" EXACT [] synonym: "haemopoietic stem cell differentiation" EXACT [] synonym: "hemopoietic stem cell differentiation" EXACT [] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0060219 name: camera-type eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0060220 name: camera-type eye photoreceptor cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0060221 name: retinal rod cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation [Term] id: GO:0060222 name: regulation of retinal cone cell fate commitment namespace: biological_process def: "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0061074 ! regulation of neural retina development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046551 ! retinal cone cell fate commitment relationship: regulates GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0060223 name: retinal rod cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment relationship: part_of GO:0060221 ! retinal rod cell differentiation [Term] id: GO:0060224 name: regulation of retinal rod cell fate commitment namespace: biological_process def: "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0061074 ! regulation of neural retina development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060223 ! retinal rod cell fate commitment relationship: regulates GO:0060223 ! retinal rod cell fate commitment [Term] id: GO:0060225 name: positive regulation of retinal rod cell fate commitment namespace: biological_process def: "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0060224 ! regulation of retinal rod cell fate commitment is_a: GO:0061075 ! positive regulation of neural retina development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060223 ! retinal rod cell fate commitment relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment [Term] id: GO:0060226 name: negative regulation of retinal cone cell fate commitment namespace: biological_process def: "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0060222 ! regulation of retinal cone cell fate commitment is_a: GO:0061076 ! negative regulation of neural retina development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046551 ! retinal cone cell fate commitment relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment [Term] id: GO:0060227 name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph] synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment [Term] id: GO:0060228 name: phosphatidylcholine-sterol O-acyltransferase activator activity namespace: molecular_function def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615] synonym: "LCAT activator activity" NARROW [GOC:tb] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0004607 ! phosphatidylcholine-sterol O-acyltransferase activity [Term] id: GO:0060229 name: lipase activator activity namespace: molecular_function def: "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0016298 ! lipase activity [Term] id: GO:0060230 name: lipoprotein lipase activator activity namespace: molecular_function def: "Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238] is_a: GO:0060229 ! lipase activator activity relationship: positively_regulates GO:0004465 ! lipoprotein lipase activity [Term] id: GO:0060231 name: mesenchymal to epithelial transition namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0060232 name: delamination namespace: biological_process def: "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] is_a: GO:0022408 ! negative regulation of cell-cell adhesion [Term] id: GO:0060233 name: oenocyte delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet." [GOC:dph] is_a: GO:0060232 ! delamination [Term] id: GO:0060234 name: neuroblast delamination namespace: biological_process def: "The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet." [GOC:dph] is_a: GO:0060232 ! delamination [Term] id: GO:0060235 name: lens induction in camera-type eye namespace: biological_process def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437] is_a: GO:0031128 ! developmental induction relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye [Term] id: GO:0060236 name: regulation of mitotic spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah] synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0090224 ! regulation of spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007052 ! mitotic spindle organization relationship: regulates GO:0007052 ! mitotic spindle organization [Term] id: GO:0060237 name: regulation of fungal-type cell wall organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb] synonym: "regulation of fungal-type cell wall organisation" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031505 ! fungal-type cell wall organization relationship: regulates GO:0031505 ! fungal-type cell wall organization [Term] id: GO:0060238 name: regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031137 ! regulation of conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion relationship: regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion [Term] id: GO:0060239 name: positive regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion relationship: positively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion [Term] id: GO:0060240 name: negative regulation of signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion relationship: negatively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion [Term] id: GO:0060241 name: lysozyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a lysozyme, an enzyme that hydrolyses the beta- (1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan." [GOC:dph] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0003796 ! lysozyme activity [Term] id: GO:0060242 name: contact inhibition namespace: biological_process alt_id: GO:0060246 alt_id: GO:0060248 def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph, PMID:17376520] synonym: "detection of cell density by contact stimulus" RELATED [] synonym: "detection of cell density by contact stimulus involved in contact inhibition" RELATED [] xref: Wikipedia:Contact_inhibition is_a: GO:0060245 ! detection of cell density [Term] id: GO:0060243 name: negative regulation of cell growth involved in contact inhibition namespace: biological_process def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph] is_a: GO:0030308 ! negative regulation of cell growth intersection_of: GO:0030308 ! negative regulation of cell growth intersection_of: part_of GO:0060242 ! contact inhibition relationship: part_of GO:0060242 ! contact inhibition [Term] id: GO:0060244 name: negative regulation of cell proliferation involved in contact inhibition namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation intersection_of: GO:0008285 ! negative regulation of cell population proliferation intersection_of: part_of GO:0060242 ! contact inhibition relationship: part_of GO:0060242 ! contact inhibition [Term] id: GO:0060245 name: detection of cell density namespace: biological_process def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph] is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0060249 name: anatomical structure homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] synonym: "anatomical structure maintenance" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process [Term] id: GO:0060250 name: germ-line stem-cell niche homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph] synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph] synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph] synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph] is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0060251 name: regulation of glial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014009 ! glial cell proliferation relationship: regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060252 name: positive regulation of glial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014009 ! glial cell proliferation relationship: positively_regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060253 name: negative regulation of glial cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014009 ! glial cell proliferation relationship: negatively_regulates GO:0014009 ! glial cell proliferation [Term] id: GO:0060254 name: regulation of N-terminal protein palmitoylation namespace: biological_process def: "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] is_a: GO:1903059 ! regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006500 ! N-terminal protein palmitoylation relationship: regulates GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043170 ! macromolecule metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0060256 name: regulation of flocculation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000128 ! flocculation relationship: regulates GO:0000128 ! flocculation [Term] id: GO:0060257 name: negative regulation of flocculation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0060256 ! regulation of flocculation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000128 ! flocculation relationship: negatively_regulates GO:0000128 ! flocculation [Term] id: GO:0060258 name: negative regulation of filamentous growth namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] is_a: GO:0010570 ! regulation of filamentous growth is_a: GO:0045926 ! negative regulation of growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030447 ! filamentous growth relationship: negatively_regulates GO:0030447 ! filamentous growth [Term] id: GO:0060259 name: regulation of feeding behavior namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007631 ! feeding behavior relationship: regulates GO:0007631 ! feeding behavior [Term] id: GO:0060260 name: regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0060261 name: positive regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter is_a: GO:2000144 ! positive regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0060262 name: negative regulation of N-terminal protein palmitoylation namespace: biological_process def: "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation is_a: GO:1903060 ! negative regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation [Term] id: GO:0060263 name: regulation of respiratory burst namespace: biological_process def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045730 ! respiratory burst relationship: regulates GO:0045730 ! respiratory burst [Term] id: GO:0060264 name: regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002536 ! respiratory burst involved in inflammatory response relationship: regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060265 name: positive regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060267 ! positive regulation of respiratory burst intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response relationship: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060266 name: negative regulation of respiratory burst involved in inflammatory response namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response is_a: GO:0060268 ! negative regulation of respiratory burst is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response relationship: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response [Term] id: GO:0060267 name: positive regulation of respiratory burst namespace: biological_process def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045730 ! respiratory burst relationship: positively_regulates GO:0045730 ! respiratory burst [Term] id: GO:0060268 name: negative regulation of respiratory burst namespace: biological_process def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060263 ! regulation of respiratory burst intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045730 ! respiratory burst relationship: negatively_regulates GO:0045730 ! respiratory burst [Term] id: GO:0060269 name: centripetally migrating follicle cell migration namespace: biological_process def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0060270 name: main body follicle cell migration namespace: biological_process def: "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte." [GOC:dph] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0060271 name: cilium assembly namespace: biological_process alt_id: GO:0042384 def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium assembly" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833.2 is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: has_part GO:0035082 ! axoneme assembly relationship: has_part GO:0035735 ! intraciliary transport involved in cilium assembly relationship: has_part GO:0061512 ! protein localization to cilium relationship: has_part GO:0097712 ! vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: has_part GO:1905349 ! ciliary transition zone assembly [Term] id: GO:0060272 name: embryonic skeletal joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton." [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982] is_a: GO:0048704 ! embryonic skeletal system morphogenesis relationship: part_of GO:0072498 ! embryonic skeletal joint development [Term] id: GO:0060273 name: crying behavior namespace: biological_process def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph] is_a: GO:0007610 ! behavior [Term] id: GO:0060274 name: maintenance of stationary phase namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph] is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0060275 name: maintenance of stationary phase in response to starvation namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph] is_a: GO:0042594 ! response to starvation is_a: GO:0060274 ! maintenance of stationary phase [Term] id: GO:0060276 name: maintenance of stationary phase in response to toxin namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph] is_a: GO:0060274 ! maintenance of stationary phase relationship: part_of GO:0009636 ! response to toxic substance [Term] id: GO:0060277 name: obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0071930 [Term] id: GO:0060278 name: regulation of ovulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030728 ! ovulation relationship: regulates GO:0030728 ! ovulation [Term] id: GO:0060279 name: positive regulation of ovulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030728 ! ovulation relationship: positively_regulates GO:0030728 ! ovulation [Term] id: GO:0060280 name: negative regulation of ovulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060278 ! regulation of ovulation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030728 ! ovulation relationship: negatively_regulates GO:0030728 ! ovulation [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048599 ! oocyte development relationship: regulates GO:0048599 ! oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1905881 ! positive regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048599 ! oocyte development relationship: positively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1905880 ! negative regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048599 ! oocyte development relationship: negatively_regulates GO:0048599 ! oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048468 ! cell development relationship: regulates GO:0048468 ! cell development [Term] id: GO:0060285 name: cilium-dependent cell motility namespace: biological_process alt_id: GO:0071974 def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. synonym: "ciliary cell motility" RELATED [] synonym: "cilium cell motility" EXACT [] synonym: "microtubule-based flagellar cell motility" EXACT [] is_a: GO:0001539 ! cilium or flagellum-dependent cell motility relationship: has_part GO:0003341 ! cilium movement [Term] id: GO:0060286 name: obsolete flagellar cell motility namespace: biological_process def: "OBSOLETE. Cell motility due to the motion of one or more flagella." [GOC:dgh, GOC:dph, GOC:mlg] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "flagellar cell motility" EXACT [] is_obsolete: true consider: GO:0060285 consider: GO:0071973 [Term] id: GO:0060287 name: epithelial cilium movement involved in determination of left/right asymmetry namespace: biological_process def: "The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579] synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT [] synonym: "Kuppfer's vesicle cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia] synonym: "nodal cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia] is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement intersection_of: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement intersection_of: part_of GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0060288 name: formation of a compartment boundary namespace: biological_process def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] synonym: "compartment boundary formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007386 ! compartment pattern specification [Term] id: GO:0060289 name: compartment boundary maintenance namespace: biological_process def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] is_a: GO:0001894 ! tissue homeostasis relationship: part_of GO:0007386 ! compartment pattern specification [Term] id: GO:0060290 name: transdifferentiation namespace: biological_process def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv] xref: Wikipedia:Transdifferentiation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0060291 name: long-term synaptic potentiation namespace: biological_process def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] synonym: "long-term potentiation" BROAD [GOC:dph] synonym: "LTP" RELATED [GOC:dph] is_a: GO:0048167 ! regulation of synaptic plasticity is_a: GO:0050806 ! positive regulation of synaptic transmission [Term] id: GO:0060292 name: long-term synaptic depression namespace: biological_process def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] synonym: "long term depression" BROAD [GOC:dph] synonym: "long term synaptic depression" EXACT [] synonym: "LTD" RELATED [GOC:dph] is_a: GO:0048167 ! regulation of synaptic plasticity is_a: GO:0050805 ! negative regulation of synaptic transmission [Term] id: GO:0060293 name: germ plasm namespace: cellular_component def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph] xref: Wikipedia:Germ_plasm is_a: GO:0045495 ! pole plasm [Term] id: GO:0060294 name: cilium movement involved in cell motility namespace: biological_process def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement intersection_of: GO:0003341 ! cilium movement intersection_of: part_of GO:0048870 ! cell motility relationship: part_of GO:0060285 ! cilium-dependent cell motility [Term] id: GO:0060295 name: regulation of cilium movement involved in cell motility namespace: biological_process def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:1902019 ! regulation of cilium-dependent cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060294 ! cilium movement involved in cell motility relationship: regulates GO:0060294 ! cilium movement involved in cell motility [Term] id: GO:0060296 name: regulation of cilium beat frequency involved in ciliary motility namespace: biological_process def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb] is_a: GO:0003356 ! regulation of cilium beat frequency is_a: GO:0060295 ! regulation of cilium movement involved in cell motility is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0060284 ! regulation of cell development is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902115 ! regulation of organelle assembly is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045214 ! sarcomere organization relationship: regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045214 ! sarcomere organization relationship: positively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045214 ! sarcomere organization relationship: negatively_regulates GO:0045214 ! sarcomere organization [Term] id: GO:0060300 name: regulation of cytokine activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005125 ! cytokine activity relationship: regulates GO:0005125 ! cytokine activity [Term] id: GO:0060301 name: positive regulation of cytokine activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060300 ! regulation of cytokine activity is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005125 ! cytokine activity relationship: positively_regulates GO:0005125 ! cytokine activity [Term] id: GO:0060302 name: negative regulation of cytokine activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060300 ! regulation of cytokine activity is_a: GO:1900121 ! negative regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005125 ! cytokine activity relationship: negatively_regulates GO:0005125 ! cytokine activity [Term] id: GO:0060303 name: regulation of nucleosome density namespace: biological_process def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb] is_a: GO:0034728 ! nucleosome organization is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060304 name: regulation of phosphatidylinositol dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol." [GOC:dph, GOC:tb] synonym: "regulation of phosphoinositide dephosphorylation" EXACT [] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046856 ! phosphatidylinositol dephosphorylation relationship: regulates GO:0046856 ! phosphatidylinositol dephosphorylation [Term] id: GO:0060305 name: regulation of cell diameter namespace: biological_process def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb] synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb] is_a: GO:0008361 ! regulation of cell size [Term] id: GO:0060306 name: regulation of membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0042391 ! regulation of membrane potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086009 ! membrane repolarization relationship: regulates GO:0086009 ! membrane repolarization [Term] id: GO:0060307 name: regulation of ventricular cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiomyocyte membrane repolarization" EXACT [] synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization relationship: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization [Term] id: GO:0060308 name: GTP cyclohydrolase I regulator activity namespace: molecular_function def: "Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0044549 ! GTP cyclohydrolase binding relationship: regulates GO:0003934 ! GTP cyclohydrolase I activity [Term] id: GO:0060309 name: elastin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb] synonym: "elastin breakdown" EXACT [] synonym: "elastin catabolism" EXACT [] synonym: "elastin degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051541 ! elastin metabolic process [Term] id: GO:0060310 name: regulation of elastin catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb] synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060309 ! elastin catabolic process relationship: regulates GO:0060309 ! elastin catabolic process [Term] id: GO:0060311 name: negative regulation of elastin catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down-regulation of elastin catabolic process" EXACT [] synonym: "negative regulation of elastin breakdown" EXACT [] synonym: "negative regulation of elastin catabolism" EXACT [] synonym: "negative regulation of elastin degradation" EXACT [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0060310 ! regulation of elastin catabolic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060309 ! elastin catabolic process relationship: negatively_regulates GO:0060309 ! elastin catabolic process [Term] id: GO:0060312 name: regulation of blood vessel remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001974 ! blood vessel remodeling relationship: regulates GO:0001974 ! blood vessel remodeling [Term] id: GO:0060313 name: negative regulation of blood vessel remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001974 ! blood vessel remodeling relationship: negatively_regulates GO:0001974 ! blood vessel remodeling [Term] id: GO:0060314 name: regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity relationship: regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity [Term] id: GO:0060315 name: negative regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity relationship: negatively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity [Term] id: GO:0060316 name: positive regulation of ryanodine-sensitive calcium-release channel activity namespace: biological_process def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity relationship: positively_regulates GO:0005219 ! ryanodine-sensitive calcium-release channel activity [Term] id: GO:0060317 name: cardiac epithelial to mesenchymal transition namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351] synonym: "heart epithelial to mesenchymal transition" EXACT [] is_a: GO:0001837 ! epithelial to mesenchymal transition relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0060318 name: definitive erythrocyte differentiation namespace: biological_process def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] synonym: "definitive erythropoiesis" EXACT [] synonym: "definitive RBC differentiation" EXACT [CL:0000232] synonym: "definitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation relationship: part_of GO:0060216 ! definitive hemopoiesis [Term] id: GO:0060319 name: primitive erythrocyte differentiation namespace: biological_process def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "primitive RBC differentiation" EXACT [CL:0000232] synonym: "primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation relationship: part_of GO:0060215 ! primitive hemopoiesis [Term] id: GO:0060320 name: rejection of self pollen namespace: biological_process def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb] is_a: GO:0048544 ! recognition of pollen [Term] id: GO:0060321 name: acceptance of pollen namespace: biological_process def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb] synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb] synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb] is_a: GO:0048544 ! recognition of pollen [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0060323 name: head morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0010171 ! body morphogenesis relationship: part_of GO:0060322 ! head development [Term] id: GO:0060324 name: face development namespace: biological_process def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060322 ! head development [Term] id: GO:0060325 name: face morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060323 ! head morphogenesis relationship: part_of GO:0060324 ! face development [Term] id: GO:0060326 name: cell chemotaxis namespace: biological_process def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration relationship: part_of GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0060327 name: cytoplasmic actin-based contraction involved in cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] is_a: GO:0070252 ! actin-mediated cell contraction intersection_of: GO:0070252 ! actin-mediated cell contraction intersection_of: part_of GO:0048870 ! cell motility relationship: part_of GO:0048870 ! cell motility [Term] id: GO:0060328 name: cytoplasmic actin-based contraction involved in forward cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph] synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED [] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility [Term] id: GO:0060329 name: cytoplasmic actin-based contraction involved in rearward cell motility namespace: biological_process def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph] synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED [] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility [Term] id: GO:0060330 name: regulation of response to interferon-gamma namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "regulation of response to gamma-interferon" RELATED [] synonym: "regulation of response to immune interferon" EXACT [] synonym: "regulation of response to type II IFN" BROAD [] synonym: "regulation of response to type II interferon" BROAD [] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034341 ! response to interferon-gamma relationship: regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060331 name: negative regulation of response to interferon-gamma namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "negative regulation of response to gamma-interferon" RELATED [] synonym: "negative regulation of response to immune interferon" EXACT [] synonym: "negative regulation of response to type II IFN" BROAD [] synonym: "negative regulation of response to type II interferon" BROAD [] is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0060330 ! regulation of response to interferon-gamma is_a: GO:0060761 ! negative regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034341 ! response to interferon-gamma relationship: negatively_regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060332 name: positive regulation of response to interferon-gamma namespace: biological_process def: "Any process that increases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] synonym: "positive regulation of response to gamma-interferon" RELATED [] synonym: "positive regulation of response to immune interferon" EXACT [] synonym: "positive regulation of response to type II IFN" BROAD [] synonym: "positive regulation of response to type II interferon" BROAD [] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0060330 ! regulation of response to interferon-gamma is_a: GO:0060760 ! positive regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034341 ! response to interferon-gamma relationship: positively_regulates GO:0034341 ! response to interferon-gamma [Term] id: GO:0060333 name: interferon-gamma-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling, PR:000000017] synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "immune interferon signaling pathway" EXACT [GOC:dph] synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "type II IFN-mediated signaling pathway" BROAD [] synonym: "type II interferon-mediated signaling pathway" BROAD [GOC:dph] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071346 ! cellular response to interferon-gamma [Term] id: GO:0060334 name: regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph] synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph] synonym: "regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0060330 ! regulation of response to interferon-gamma intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060335 name: positive regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of type II IFN-mediated pathway" BROAD [GOC:dph] synonym: "positive regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0060332 ! positive regulation of response to interferon-gamma is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060336 name: negative regulation of interferon-gamma-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph] synonym: "negative regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0060331 ! negative regulation of response to interferon-gamma is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway [Term] id: GO:0060337 name: type I interferon signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling, PR:000025848] synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling] synonym: "type I interferon-mediated signaling pathway" RELATED [GOC:signaling] synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071357 ! cellular response to type I interferon [Term] id: GO:0060338 name: regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060337 ! type I interferon signaling pathway relationship: regulates GO:0060337 ! type I interferon signaling pathway [Term] id: GO:0060339 name: negative regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060337 ! type I interferon signaling pathway relationship: negatively_regulates GO:0060337 ! type I interferon signaling pathway [Term] id: GO:0060340 name: positive regulation of type I interferon-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060337 ! type I interferon signaling pathway relationship: positively_regulates GO:0060337 ! type I interferon signaling pathway [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051641 ! cellular localization relationship: regulates GO:0051641 ! cellular localization [Term] id: GO:0060342 name: photoreceptor inner segment membrane namespace: cellular_component def: "The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0001917 ! photoreceptor inner segment [Term] id: GO:0060343 name: trabecula formation namespace: biological_process def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] synonym: "trabecula biogenesis" RELATED [GOC:dph] synonym: "trabeculation" EXACT [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0061383 ! trabecula morphogenesis [Term] id: GO:0060344 name: liver trabecula formation namespace: biological_process def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "liver trabecula biogenesis" RELATED [] synonym: "liver trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0001889 ! liver development [Term] id: GO:0060345 name: spleen trabecula formation namespace: biological_process def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] synonym: "spleen trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0048536 ! spleen development [Term] id: GO:0060346 name: bone trabecula formation namespace: biological_process def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "bone trabecula biogenesis" RELATED [GOC:dph] synonym: "bone trabeculation" EXACT [GOC:dph] synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph] synonym: "skeletal trabecula formation" EXACT [GOC:dph] synonym: "skeletal trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0061430 ! bone trabecula morphogenesis [Term] id: GO:0060347 name: heart trabecula formation namespace: biological_process def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] synonym: "cardiac trabecula formation" EXACT [GOC:dph] synonym: "cardiac trabeculation" EXACT [GOC:dph] synonym: "heart trabecula biogenesis" RELATED [GOC:dph] synonym: "heart trabeculation" EXACT [GOC:dph] is_a: GO:0060343 ! trabecula formation relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0061384 ! heart trabecula morphogenesis [Term] id: GO:0060348 name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0001501 ! skeletal system development [Term] id: GO:0060349 name: bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0060348 ! bone development [Term] id: GO:0060350 name: endochondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] is_a: GO:0060349 ! bone morphogenesis [Term] id: GO:0060351 name: cartilage development involved in endochondral bone morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0051216 ! cartilage development intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0060352 name: cell adhesion molecule production namespace: biological_process def: "The appearance of a cell adhesion molecule due to biosynthesis or secretion." [GOC:BHF, GOC:rl] is_a: GO:0009987 ! cellular process [Term] id: GO:0060353 name: regulation of cell adhesion molecule production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060352 ! cell adhesion molecule production relationship: regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060354 name: negative regulation of cell adhesion molecule production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060353 ! regulation of cell adhesion molecule production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060352 ! cell adhesion molecule production relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060355 name: positive regulation of cell adhesion molecule production namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060353 ! regulation of cell adhesion molecule production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060352 ! cell adhesion molecule production relationship: positively_regulates GO:0060352 ! cell adhesion molecule production [Term] id: GO:0060357 name: regulation of leucine import namespace: biological_process def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb] synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb] synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:1905532 ! regulation of leucine import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903801 ! L-leucine import across plasma membrane relationship: regulates GO:1903801 ! L-leucine import across plasma membrane [Term] id: GO:0060358 name: negative regulation of leucine import namespace: biological_process def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0060357 ! regulation of leucine import is_a: GO:1905533 ! negative regulation of leucine import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903801 ! L-leucine import across plasma membrane relationship: negatively_regulates GO:1903801 ! L-leucine import across plasma membrane [Term] id: GO:0060359 name: response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb] is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0060360 name: negative regulation of leucine import in response to ammonium ion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT [] is_a: GO:0060358 ! negative regulation of leucine import relationship: part_of GO:0071242 ! cellular response to ammonium ion [Term] id: GO:0060361 name: flight namespace: biological_process def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] is_a: GO:0040011 ! locomotion [Term] id: GO:0060362 name: flight involved in flight behavior namespace: biological_process def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph] is_a: GO:0031987 ! locomotion involved in locomotory behavior is_a: GO:0060361 ! flight intersection_of: GO:0060361 ! flight intersection_of: part_of GO:0007629 ! flight behavior relationship: part_of GO:0007629 ! flight behavior [Term] id: GO:0060363 name: cranial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl] is_a: GO:0097094 ! craniofacial suture morphogenesis [Term] id: GO:0060364 name: frontal suture morphogenesis namespace: biological_process def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl] synonym: "interfrontal suture morphogenesis" EXACT [] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060365 name: coronal suture morphogenesis namespace: biological_process def: "The process in which the coronal suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060366 name: lambdoid suture morphogenesis namespace: biological_process def: "The process in which the lambdoid suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060367 name: sagittal suture morphogenesis namespace: biological_process def: "The process in which the sagittal suture is generated and organized." [GOC:dph, GOC:sl] is_a: GO:0060363 ! cranial suture morphogenesis [Term] id: GO:0060368 name: regulation of Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:dph, GOC:tb] synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway [Term] id: GO:0060369 name: positive regulation of Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0050778 ! positive regulation of immune response is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway [Term] id: GO:0060370 name: susceptibility to T cell mediated cytotoxicity namespace: biological_process def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity [Term] id: GO:0060371 name: regulation of atrial cardiac muscle cell membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiomyocyte membrane depolarization" EXACT [] is_a: GO:0003254 ! regulation of membrane depolarization [Term] id: GO:0060372 name: regulation of atrial cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] synonym: "regulation of atrial cardiomyocyte membrane repolarization" EXACT [] is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization relationship: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization [Term] id: GO:0060373 name: regulation of ventricular cardiac muscle cell membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiomyocyte membrane depolarization" EXACT [] synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0003254 ! regulation of membrane depolarization [Term] id: GO:0060374 name: mast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0060375 name: regulation of mast cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060374 ! mast cell differentiation relationship: regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060376 name: positive regulation of mast cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060374 ! mast cell differentiation relationship: positively_regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060377 name: negative regulation of mast cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0060375 ! regulation of mast cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060374 ! mast cell differentiation relationship: negatively_regulates GO:0060374 ! mast cell differentiation [Term] id: GO:0060378 name: regulation of brood size namespace: biological_process def: "Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation is_a: GO:0045445 ! myoblast differentiation [Term] id: GO:0060380 name: regulation of single-stranded telomeric DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb] synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:1904742 ! regulation of telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043047 ! single-stranded telomeric DNA binding relationship: regulates GO:0043047 ! single-stranded telomeric DNA binding [Term] id: GO:0060381 name: positive regulation of single-stranded telomeric DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah] is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding is_a: GO:1904744 ! positive regulation of telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043047 ! single-stranded telomeric DNA binding relationship: positively_regulates GO:0043047 ! single-stranded telomeric DNA binding [Term] id: GO:0060382 name: regulation of DNA strand elongation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022616 ! DNA strand elongation relationship: regulates GO:0022616 ! DNA strand elongation [Term] id: GO:0060383 name: positive regulation of DNA strand elongation namespace: biological_process def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0060382 ! regulation of DNA strand elongation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022616 ! DNA strand elongation relationship: positively_regulates GO:0022616 ! DNA strand elongation [Term] id: GO:0060384 name: innervation namespace: biological_process def: "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0021675 ! nerve development [Term] id: GO:0060385 name: axonogenesis involved in innervation namespace: biological_process def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart] is_a: GO:0007409 ! axonogenesis intersection_of: GO:0007409 ! axonogenesis intersection_of: part_of GO:0060384 ! innervation relationship: part_of GO:0060384 ! innervation [Term] id: GO:0060386 name: synapse assembly involved in innervation namespace: biological_process def: "The assembly of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:pr, GOC:sart] synonym: "synapse biogenesis involved in innervation" EXACT [] synonym: "synaptogenesis involved in innervation" EXACT [] is_a: GO:0007416 ! synapse assembly intersection_of: GO:0007416 ! synapse assembly intersection_of: part_of GO:0060384 ! innervation relationship: part_of GO:0060384 ! innervation [Term] id: GO:0060387 name: fertilization envelope namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437] synonym: "fertilization membrane" RELATED [] is_a: GO:0035805 ! egg coat [Term] id: GO:0060388 name: vitelline envelope namespace: cellular_component def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437] synonym: "fertilization membrane" RELATED [] is_a: GO:0035805 ! egg coat [Term] id: GO:0060389 name: pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782] synonym: "pathway restricted SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "R-SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "receptor regulated SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "receptor-regulated SMAD protein phosphorylation" EXACT [GOC:rl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0060390 name: regulation of SMAD protein signal transduction namespace: biological_process alt_id: GO:0007184 def: "Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] synonym: "SMAD protein import into nucleus" NARROW [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060395 ! SMAD protein signal transduction relationship: regulates GO:0060395 ! SMAD protein signal transduction [Term] id: GO:0060391 name: positive regulation of SMAD protein signal transduction namespace: biological_process def: "Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of SMAD protein import into nucleus" NARROW [] synonym: "positive regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0060390 ! regulation of SMAD protein signal transduction is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060395 ! SMAD protein signal transduction relationship: positively_regulates GO:0060395 ! SMAD protein signal transduction [Term] id: GO:0060392 name: negative regulation of SMAD protein signal transduction namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of SMAD protein import into nucleus" NARROW [] synonym: "negative regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] is_a: GO:0060390 ! regulation of SMAD protein signal transduction is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060395 ! SMAD protein signal transduction relationship: negatively_regulates GO:0060395 ! SMAD protein signal transduction [Term] id: GO:0060393 name: regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0060394 name: negative regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0060395 name: SMAD protein signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0060396 name: growth hormone receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442] synonym: "cellular response to growth hormone" RELATED [GOC:dph] synonym: "GH receptor signaling pathway" RELATED [GOC:dph] synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0071378 ! cellular response to growth hormone stimulus [Term] id: GO:0060397 name: growth hormone receptor signaling pathway via JAK-STAT namespace: biological_process def: "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442] synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph] is_a: GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060398 name: regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060396 ! growth hormone receptor signaling pathway relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060399 name: positive regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060400 name: negative regulation of growth hormone receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph] synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway [Term] id: GO:0060401 name: cytosolic calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the cytosol." [GOC:dph, GOC:tb] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0060402 name: calcium ion transport into cytosol namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0060401 ! cytosolic calcium ion transport [Term] id: GO:0060403 name: post-mating oviposition namespace: biological_process def: "The deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb] is_a: GO:0018991 ! oviposition is_a: GO:0045297 ! post-mating behavior [Term] id: GO:0060404 name: axonemal microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010938 ! cytoplasmic microtubule depolymerization is_a: GO:0061523 ! cilium disassembly intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: occurs_in GO:0005930 ! axoneme relationship: occurs_in GO:0005930 ! axoneme [Term] id: GO:0060405 name: regulation of penile erection namespace: biological_process def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043084 ! penile erection relationship: regulates GO:0043084 ! penile erection [Term] id: GO:0060406 name: positive regulation of penile erection namespace: biological_process def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060405 ! regulation of penile erection is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043084 ! penile erection relationship: positively_regulates GO:0043084 ! penile erection [Term] id: GO:0060407 name: negative regulation of penile erection namespace: biological_process def: "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060405 ! regulation of penile erection is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043084 ! penile erection relationship: negatively_regulates GO:0043084 ! penile erection [Term] id: GO:0060408 name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008291 ! acetylcholine metabolic process relationship: regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008291 ! acetylcholine metabolic process relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060410 name: negative regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008291 ! acetylcholine metabolic process relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process [Term] id: GO:0060411 name: cardiac septum morphogenesis namespace: biological_process alt_id: GO:0003280 def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] synonym: "heart septum morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003279 ! cardiac septum development [Term] id: GO:0060412 name: ventricular septum morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003281 ! ventricular septum development [Term] id: GO:0060413 name: atrial septum morphogenesis namespace: biological_process alt_id: GO:0003287 def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003209 ! cardiac atrium morphogenesis relationship: part_of GO:0003283 ! atrial septum development [Term] id: GO:0060414 name: aorta smooth muscle tissue morphogenesis namespace: biological_process def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0035909 ! aorta morphogenesis relationship: part_of GO:0048745 ! smooth muscle tissue development [Term] id: GO:0060415 name: muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048644 ! muscle organ morphogenesis [Term] id: GO:0060416 name: response to growth hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph] synonym: "response to growth hormone stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0060417 name: yolk namespace: cellular_component def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0060418 name: yolk plasma namespace: cellular_component def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0060417 ! yolk [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth relationship: part_of GO:0007507 ! heart development [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060419 ! heart growth relationship: regulates GO:0060419 ! heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060419 ! heart growth relationship: positively_regulates GO:0060419 ! heart growth [Term] id: GO:0060422 name: peptidyl-dipeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb] is_a: GO:0030414 ! peptidase inhibitor activity [Term] id: GO:0060423 name: foregut regionalization namespace: biological_process def: "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung] is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0060424 name: lung field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0010092 ! specification of animal organ identity is_a: GO:0060423 ! foregut regionalization relationship: part_of GO:0060431 ! primary lung bud formation [Term] id: GO:0060425 name: lung morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060426 name: lung vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0001944 ! vasculature development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060427 name: lung connective tissue development namespace: biological_process def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary connective tissue development" EXACT [] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060428 name: lung epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] subset: goslim_drosophila is_a: GO:0009888 ! tissue development [Term] id: GO:0060430 name: lung saccule development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung] synonym: "lung saccular development" BROAD [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048286 ! lung alveolus development [Term] id: GO:0060431 name: primary lung bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] synonym: "lung formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis is_a: GO:0060572 ! morphogenesis of an epithelial bud [Term] id: GO:0060432 name: lung pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060433 name: bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0030323 ! respiratory tube development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0060434 name: bronchus morphogenesis namespace: biological_process def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0060433 ! bronchus development [Term] id: GO:0060435 name: bronchiole development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0030323 ! respiratory tube development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060436 name: bronchiole morphogenesis namespace: biological_process def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0060435 ! bronchiole development [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060438 name: trachea development namespace: biological_process def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0060439 name: trachea morphogenesis namespace: biological_process def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0060438 ! trachea development [Term] id: GO:0060440 name: trachea formation namespace: biological_process def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048645 ! animal organ formation relationship: part_of GO:0060439 ! trachea morphogenesis [Term] id: GO:0060441 name: epithelial tube branching involved in lung morphogenesis namespace: biological_process def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] synonym: "lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060425 ! lung morphogenesis [Term] id: GO:0060442 name: branching involved in prostate gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] synonym: "prostate branching" RELATED [GOC:dph] synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0060512 ! prostate gland morphogenesis [Term] id: GO:0060443 name: mammary gland morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0060444 name: branching involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0060603 ! mammary gland duct morphogenesis relationship: part_of GO:0060603 ! mammary gland duct morphogenesis [Term] id: GO:0060445 name: branching involved in salivary gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0007435 ! salivary gland morphogenesis relationship: part_of GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0060446 name: branching involved in open tracheal system development namespace: biological_process def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0007424 ! open tracheal system development relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0060447 name: bud outgrowth involved in lung branching namespace: biological_process def: "The process in which a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung] synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060448 name: dichotomous subdivision of terminal units involved in lung branching namespace: biological_process def: "The process in which a lung bud bifurcates." [GOC:dph, GOC:mtg_lung] synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060449 name: bud elongation involved in lung branching namespace: biological_process def: "The process in which a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung] is_a: GO:0060602 ! branch elongation of an epithelium relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060450 name: positive regulation of hindgut contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043133 ! hindgut contraction relationship: positively_regulates GO:0043133 ! hindgut contraction [Term] id: GO:0060451 name: negative regulation of hindgut contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] is_a: GO:0043134 ! regulation of hindgut contraction is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043133 ! hindgut contraction relationship: negatively_regulates GO:0043133 ! hindgut contraction [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060048 ! cardiac muscle contraction relationship: positively_regulates GO:0060048 ! cardiac muscle contraction [Term] id: GO:0060453 name: regulation of gastric acid secretion namespace: biological_process def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001696 ! gastric acid secretion relationship: regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060454 name: positive regulation of gastric acid secretion namespace: biological_process def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060456 ! positive regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001696 ! gastric acid secretion relationship: positively_regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060455 name: negative regulation of gastric acid secretion namespace: biological_process def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060453 ! regulation of gastric acid secretion is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001696 ! gastric acid secretion relationship: negatively_regulates GO:0001696 ! gastric acid secretion [Term] id: GO:0060456 name: positive regulation of digestive system process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022600 ! digestive system process relationship: positively_regulates GO:0022600 ! digestive system process [Term] id: GO:0060457 name: negative regulation of digestive system process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022600 ! digestive system process relationship: negatively_regulates GO:0022600 ! digestive system process [Term] id: GO:0060458 name: right lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0030324 ! lung development [Term] id: GO:0060459 name: left lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "left pulmonary development" EXACT [GOC:dph] is_a: GO:0030324 ! lung development [Term] id: GO:0060460 name: left lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] is_a: GO:0060425 ! lung morphogenesis relationship: part_of GO:0060459 ! left lung development [Term] id: GO:0060461 name: right lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] is_a: GO:0060425 ! lung morphogenesis relationship: part_of GO:0060458 ! right lung development [Term] id: GO:0060462 name: lung lobe development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060463 name: lung lobe morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060462 ! lung lobe development [Term] id: GO:0060464 name: lung lobe formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060463 ! lung lobe morphogenesis [Term] id: GO:0060465 name: pharynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] synonym: "pharyngeal development" RELATED [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0060466 name: activation of meiosis involved in egg activation namespace: biological_process def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph] synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph] synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0090427 ! activation of meiosis intersection_of: GO:0090427 ! activation of meiosis intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009566 ! fertilization relationship: negatively_regulates GO:0009566 ! fertilization [Term] id: GO:0060468 name: prevention of polyspermy namespace: biological_process def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] synonym: "polyspermy block" EXACT [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0060467 ! negative regulation of fertilization intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060469 name: positive regulation of transcription involved in egg activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph] synonym: "activation of the egg genome" RELATED [GOC:dph] synonym: "activation of the maternal genome" RELATED [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060470 name: positive regulation of cytosolic calcium ion concentration involved in egg activation namespace: biological_process def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph] synonym: "elevation of cytosolic calcium ion concentration involved in egg activation" EXACT [] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0022414 ! reproductive process intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: part_of GO:0007343 ! egg activation relationship: part_of GO:0007343 ! egg activation [Term] id: GO:0060471 name: cortical granule exocytosis namespace: biological_process def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph] synonym: "cortical granule release" RELATED [GOC:dph] synonym: "cortical reaction" RELATED [PMID:22088197] is_a: GO:0017156 ! calcium-ion regulated exocytosis is_a: GO:0022414 ! reproductive process relationship: part_of GO:0060468 ! prevention of polyspermy [Term] id: GO:0060472 name: positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph] synonym: "positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:0060470 ! positive regulation of cytosolic calcium ion concentration involved in egg activation is_a: GO:1905516 ! positive regulation of fertilization relationship: positively_regulates GO:0060471 ! cortical granule exocytosis [Term] id: GO:0060473 name: cortical granule namespace: cellular_component def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph] synonym: "cortical vesicle" RELATED [GOC:dph] is_a: GO:0030141 ! secretory granule [Term] id: GO:0060474 name: positive regulation of flagellated sperm motility involved in capacitation namespace: biological_process def: "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." [GOC:cilia, GOC:dph, GOC:krc] synonym: "positive regulation of sperm motility involved in capacitation" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:1902093 ! positive regulation of flagellated sperm motility intersection_of: GO:1902093 ! positive regulation of flagellated sperm motility intersection_of: part_of GO:0048240 ! sperm capacitation relationship: part_of GO:0048240 ! sperm capacitation [Term] id: GO:0060475 name: positive regulation of actin filament polymerization involved in acrosome reaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph] synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0030838 ! positive regulation of actin filament polymerization intersection_of: GO:0030838 ! positive regulation of actin filament polymerization intersection_of: part_of GO:0007340 ! acrosome reaction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060476 name: protein localization involved in acrosome reaction namespace: biological_process def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph] synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0030029 ! actin filament-based process is_a: GO:0034613 ! cellular protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0007340 ! acrosome reaction relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060477 name: obsolete peptidyl-serine phosphorylation involved in acrosome reaction namespace: biological_process def: "OBSOLETE. The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph] comment: The reason for obsoletion is that this term does not represent a specific process. See https://github.com/geneontology/go-ontology/issues/14281 is_obsolete: true [Term] id: GO:0060478 name: acrosomal vesicle exocytosis namespace: biological_process def: "The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction." [GOC:dph] synonym: "acrosomal granule exocytosis" RELATED [GOC:dph] synonym: "acrosome exocytosis" EXACT [GOC:dph] is_a: GO:0017156 ! calcium-ion regulated exocytosis is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0060479 name: lung cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060480 name: lung goblet cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary goblet cell differentiation" EXACT [] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0061140 ! lung secretory cell differentiation relationship: part_of GO:0060481 ! lobar bronchus epithelium development [Term] id: GO:0060481 name: lobar bronchus epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060482 ! lobar bronchus development [Term] id: GO:0060482 name: lobar bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung] is_a: GO:0060433 ! bronchus development [Term] id: GO:0060483 name: lobar bronchus mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung] is_a: GO:0060484 ! lung-associated mesenchyme development relationship: part_of GO:0060482 ! lobar bronchus development [Term] id: GO:0060484 name: lung-associated mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung] synonym: "lung mesenchyme development" EXACT [GOC:dph] synonym: "pulmonary mesenchyme development" EXACT [GOC:dph] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060485 name: mesenchyme development namespace: biological_process def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] synonym: "mesenchymal development" EXACT [GOC:dph] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0060486 name: club cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung, PMID:28144783] synonym: "Clara cell differentiation" EXACT [PMID:28144783] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0060487 name: lung epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060479 ! lung cell differentiation relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060488 name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis namespace: biological_process def: "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching [Term] id: GO:0060489 name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis namespace: biological_process def: "The process in which a lung bud bifurcates parallel to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching [Term] id: GO:0060490 name: lateral sprouting involved in lung morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030031 ! cell projection assembly relationship: regulates GO:0030031 ! cell projection assembly [Term] id: GO:0060492 name: lung induction namespace: biological_process def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph] is_a: GO:0001759 ! organ induction is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis intersection_of: GO:0001759 ! organ induction intersection_of: positively_regulates GO:0060424 ! lung field specification relationship: positively_regulates GO:0060424 ! lung field specification [Term] id: GO:0060493 name: mesenchymal-endodermal cell signaling involved in lung induction namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-endodermal cell signalling involved in lung induction" EXACT [GOC:mah] is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling is_a: GO:0060496 ! mesenchymal-epithelial cell signaling involved in lung development is_a: GO:0060497 ! mesenchymal-endodermal cell signaling intersection_of: GO:0060497 ! mesenchymal-endodermal cell signaling intersection_of: part_of GO:0060492 ! lung induction relationship: part_of GO:0060492 ! lung induction [Term] id: GO:0060494 name: inductive mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung] synonym: "inductive mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0060495 name: cell-cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0030324 ! lung development relationship: part_of GO:0030324 ! lung development [Term] id: GO:0060496 name: mesenchymal-epithelial cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: part_of GO:0030324 ! lung development [Term] id: GO:0060497 name: mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling [Term] id: GO:0060498 name: retinoic acid receptor signaling pathway involved in lung bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung] synonym: "retinoic acid receptor signalling pathway involved in lung bud formation" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0060431 ! primary lung bud formation [Term] id: GO:0060499 name: fibroblast growth factor receptor signaling pathway involved in lung induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung] synonym: "fibroblast growth factor receptor signalling pathway involved in lung induction" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0031131 ! reception of an inductive signal is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0060492 ! lung induction relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction [Term] id: GO:0060500 name: obsolete regulation of transcription from RNA polymerase II promoter involved in lung bud formation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0060501 name: positive regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis [Term] id: GO:0060502 name: epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060503 name: bud dilation involved in lung branching namespace: biological_process def: "The process in which a bud in the lung increases radially." [GOC:dph] synonym: "bud expansion" EXACT [GOC:dph] is_a: GO:0003401 ! axis elongation relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis [Term] id: GO:0060504 name: positive regulation of epithelial cell proliferation involved in lung bud dilation namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation [Term] id: GO:0060505 name: epithelial cell proliferation involved in lung bud dilation namespace: biological_process def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph] is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0060503 ! bud dilation involved in lung branching relationship: part_of GO:0060503 ! bud dilation involved in lung branching [Term] id: GO:0060506 name: smoothened signaling pathway involved in lung development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] synonym: "hedgehog signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in lung development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0030324 ! lung development relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development [Term] id: GO:0060507 name: epidermal growth factor receptor signaling pathway involved in lung development namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] synonym: "epidermal growth factor receptor signalling pathway involved in lung development" EXACT [GOC:mah] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: part_of GO:0030324 ! lung development relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development [Term] id: GO:0060508 name: lung basal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary basal cell differentiation" BROAD [GOC:dph, GOC:mtg_lung] is_a: GO:0060479 ! lung cell differentiation relationship: part_of GO:0060428 ! lung epithelium development [Term] id: GO:0060509 name: type I pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544] synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] is_a: GO:0060487 ! lung epithelial cell differentiation [Term] id: GO:0060510 name: type II pneumocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544] synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544] synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] is_a: GO:0061140 ! lung secretory cell differentiation [Term] id: GO:0060511 name: creation of an inductive signal by a mesenchymal cell involved in lung induction namespace: biological_process def: "The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung] is_a: GO:0031130 ! creation of an inductive signal relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction [Term] id: GO:0060512 name: prostate gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060513 name: prostatic bud formation namespace: biological_process def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204] synonym: "primary prostate bud formation" EXACT [GOC:dph] synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393] synonym: "prostate gland formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0060601 ! lateral sprouting from an epithelium is_a: GO:0060740 ! prostate gland epithelium morphogenesis [Term] id: GO:0060514 name: prostate induction namespace: biological_process def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204] is_a: GO:0001759 ! organ induction is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0001759 ! organ induction intersection_of: positively_regulates GO:0060515 ! prostate field specification relationship: positively_regulates GO:0060515 ! prostate field specification [Term] id: GO:0060515 name: prostate field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010092 ! specification of animal organ identity relationship: part_of GO:0060513 ! prostatic bud formation [Term] id: GO:0060516 name: primary prostatic bud elongation namespace: biological_process def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204] synonym: "prostate bud elongation" BROAD [GOC:dph] synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium is_a: GO:0060737 ! prostate gland morphogenetic growth is_a: GO:0060740 ! prostate gland epithelium morphogenesis [Term] id: GO:0060517 name: epithelial cell proliferation involved in prostatic bud elongation namespace: biological_process def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0060516 ! primary prostatic bud elongation relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060518 name: cell migration involved in prostatic bud elongation namespace: biological_process def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0022414 ! reproductive process intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0060516 ! primary prostatic bud elongation relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060519 name: cell adhesion involved in prostatic bud elongation namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] is_a: GO:0007155 ! cell adhesion is_a: GO:0022414 ! reproductive process relationship: part_of GO:0060516 ! primary prostatic bud elongation [Term] id: GO:0060520 name: activation of prostate induction by androgen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204] synonym: "activation of prostate induction by androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0030521 ! androgen receptor signaling pathway is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0060514 ! prostate induction [Term] id: GO:0060521 name: mesenchymal-epithelial cell signaling involved in prostate induction namespace: biological_process def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204] synonym: "mesenchymal-epithelial cell signalling involved in prostate induction" EXACT [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: part_of GO:0060514 ! prostate induction relationship: part_of GO:0060514 ! prostate induction [Term] id: GO:0060522 name: inductive mesenchymal to epithelial cell signaling namespace: biological_process def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph] synonym: "inductive mesenchymal to epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0060523 name: prostate epithelial cord elongation namespace: biological_process def: "The developmental growth process in which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204] is_a: GO:0060602 ! branch elongation of an epithelium is_a: GO:0060737 ! prostate gland morphogenetic growth is_a: GO:0060740 ! prostate gland epithelium morphogenesis relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis [Term] id: GO:0060524 name: dichotomous subdivision of prostate epithelial cord terminal unit namespace: biological_process def: "The process in which a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204] synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis [Term] id: GO:0060525 name: prostate glandular acinus development namespace: biological_process def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0030850 ! prostate gland development [Term] id: GO:0060526 name: prostate glandular acinus morphogenesis namespace: biological_process def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph] is_a: GO:0060740 ! prostate gland epithelium morphogenesis relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060527 name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis namespace: biological_process def: "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204] is_a: GO:0060442 ! branching involved in prostate gland morphogenesis relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis [Term] id: GO:0060528 name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060529 name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0048863 ! stem cell differentiation is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060530 name: smooth muscle cell differentiation involved in prostate glandular acinus development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0051145 ! smooth muscle cell differentiation intersection_of: part_of GO:0060525 ! prostate glandular acinus development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060531 name: neuroendocrine cell differentiation involved in prostate gland acinus development namespace: biological_process def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204] is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development is_a: GO:0061101 ! neuroendocrine cell differentiation intersection_of: GO:0061101 ! neuroendocrine cell differentiation intersection_of: part_of GO:0060525 ! prostate glandular acinus development relationship: part_of GO:0060525 ! prostate glandular acinus development [Term] id: GO:0060532 name: bronchus cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cartilage development" EXACT [] is_a: GO:0051216 ! cartilage development relationship: part_of GO:0060433 ! bronchus development created_by: dph creation_date: 2009-04-10T08:12:06Z [Term] id: GO:0060533 name: bronchus cartilage morphogenesis namespace: biological_process def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0060434 ! bronchus morphogenesis relationship: part_of GO:0060532 ! bronchus cartilage development created_by: dph creation_date: 2009-04-10T08:47:41Z [Term] id: GO:0060534 name: trachea cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051216 ! cartilage development relationship: part_of GO:0060438 ! trachea development created_by: dph creation_date: 2009-04-10T09:00:18Z [Term] id: GO:0060535 name: trachea cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0060439 ! trachea morphogenesis relationship: part_of GO:0060534 ! trachea cartilage development created_by: dph creation_date: 2009-04-10T09:07:48Z [Term] id: GO:0060536 name: cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0051216 ! cartilage development created_by: dph creation_date: 2009-04-10T09:13:27Z [Term] id: GO:0060537 name: muscle tissue development namespace: biological_process def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] is_a: GO:0009888 ! tissue development created_by: dph creation_date: 2009-04-10T08:05:37Z [Term] id: GO:0060538 name: skeletal muscle organ development namespace: biological_process def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] is_a: GO:0007517 ! muscle organ development created_by: dph creation_date: 2009-04-10T08:25:12Z [Term] id: GO:0060539 name: diaphragm development namespace: biological_process def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] is_a: GO:0060538 ! skeletal muscle organ development relationship: part_of GO:0060541 ! respiratory system development created_by: dph creation_date: 2009-04-10T08:44:56Z [Term] id: GO:0060540 name: diaphragm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] is_a: GO:0048644 ! muscle organ morphogenesis relationship: part_of GO:0060539 ! diaphragm development created_by: dph creation_date: 2009-04-10T08:47:51Z [Term] id: GO:0060541 name: respiratory system development namespace: biological_process def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] subset: goslim_drosophila is_a: GO:0048731 ! system development created_by: dph creation_date: 2009-04-10T08:55:42Z [Term] id: GO:0060542 name: regulation of strand invasion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042148 ! strand invasion relationship: regulates GO:0042148 ! strand invasion created_by: dph creation_date: 2009-04-13T01:28:41Z [Term] id: GO:0060543 name: negative regulation of strand invasion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb] synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh] synonym: "negative regulation of D-loop formation" RELATED [GOC:elh] synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh] is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0060542 ! regulation of strand invasion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042148 ! strand invasion relationship: negatively_regulates GO:0042148 ! strand invasion created_by: dph creation_date: 2009-04-13T01:32:36Z [Term] id: GO:0060544 name: regulation of necroptotic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of necroptosis" NARROW [] is_a: GO:0062098 ! regulation of programmed necrotic cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070266 ! necroptotic process relationship: regulates GO:0070266 ! necroptotic process created_by: dph creation_date: 2009-04-13T01:43:22Z [Term] id: GO:0060545 name: positive regulation of necroptotic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of necroptosis" NARROW [] is_a: GO:0060544 ! regulation of necroptotic process is_a: GO:0062100 ! positive regulation of programmed necrotic cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070266 ! necroptotic process relationship: positively_regulates GO:0070266 ! necroptotic process created_by: dph creation_date: 2009-04-13T01:47:27Z [Term] id: GO:0060546 name: negative regulation of necroptotic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of necroptosis" NARROW [] is_a: GO:0060544 ! regulation of necroptotic process is_a: GO:0062099 ! negative regulation of programmed necrotic cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070266 ! necroptotic process relationship: negatively_regulates GO:0070266 ! necroptotic process created_by: dph creation_date: 2009-04-13T01:49:36Z [Term] id: GO:0060547 name: negative regulation of necrotic cell death namespace: biological_process def: "Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0060548 ! negative regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070265 ! necrotic cell death relationship: negatively_regulates GO:0070265 ! necrotic cell death created_by: dph creation_date: 2009-04-13T01:51:25Z [Term] id: GO:0060548 name: negative regulation of cell death namespace: biological_process def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008219 ! cell death relationship: negatively_regulates GO:0008219 ! cell death created_by: dph creation_date: 2009-04-13T01:56:10Z [Term] id: GO:0060549 name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity relationship: regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity created_by: dph creation_date: 2009-04-13T02:07:32Z [Term] id: GO:0060550 name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity relationship: positively_regulates GO:0042132 ! fructose 1,6-bisphosphate 1-phosphatase activity created_by: dph creation_date: 2009-04-13T02:12:33Z [Term] id: GO:0060551 name: regulation of fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process created_by: dph creation_date: 2009-04-13T02:20:04Z [Term] id: GO:0060552 name: positive regulation of fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process created_by: dph creation_date: 2009-04-13T02:23:40Z [Term] id: GO:0060556 name: regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042368 ! vitamin D biosynthetic process relationship: regulates GO:0042368 ! vitamin D biosynthetic process created_by: dph creation_date: 2009-04-13T02:42:15Z [Term] id: GO:0060557 name: positive regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042368 ! vitamin D biosynthetic process relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process created_by: dph creation_date: 2009-04-13T02:46:14Z [Term] id: GO:0060558 name: regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004498 ! calcidiol 1-monooxygenase activity relationship: regulates GO:0004498 ! calcidiol 1-monooxygenase activity created_by: dph creation_date: 2009-04-13T02:52:18Z [Term] id: GO:0060559 name: positive regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0060557 ! positive regulation of vitamin D biosynthetic process is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity relationship: positively_regulates GO:0004498 ! calcidiol 1-monooxygenase activity created_by: dph creation_date: 2009-04-13T02:57:28Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis created_by: dph creation_date: 2009-04-28T09:33:36Z [Term] id: GO:0060563 name: neuroepithelial cell differentiation namespace: biological_process def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation created_by: dph creation_date: 2009-04-29T01:50:05Z [Term] id: GO:0060565 name: obsolete inhibition of APC-Cdc20 complex activity namespace: biological_process def: "OBSOLETE. Any process that prevents the activation of APC-Cdc20 complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb] comment: This term was made obsolete because it was not clearly defined and thus used incorrectly in annotation. synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of APC-Cdc20 complex activity" EXACT [] synonym: "inhibition of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "inhibition of mitotic anaphase-promoting complex activity" RELATED [GOC:vw] is_obsolete: true consider: GO:1990948 created_by: dph creation_date: 2009-04-29T02:29:31Z [Term] id: GO:0060566 name: positive regulation of DNA-templated transcription, termination namespace: biological_process def: "Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "positive regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "positive regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "positive regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] is_a: GO:0031554 ! regulation of DNA-templated transcription, termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006353 ! DNA-templated transcription, termination relationship: positively_regulates GO:0006353 ! DNA-templated transcription, termination created_by: dph creation_date: 2009-04-29T02:54:50Z [Term] id: GO:0060567 name: negative regulation of DNA-templated transcription, termination namespace: biological_process def: "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "negative regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "negative regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "negative regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] is_a: GO:0031554 ! regulation of DNA-templated transcription, termination is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006353 ! DNA-templated transcription, termination relationship: negatively_regulates GO:0006353 ! DNA-templated transcription, termination created_by: dph creation_date: 2009-04-29T02:59:12Z [Term] id: GO:0060568 name: regulation of peptide hormone processing namespace: biological_process def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0070613 ! regulation of protein processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016486 ! peptide hormone processing relationship: regulates GO:0016486 ! peptide hormone processing created_by: dph creation_date: 2009-04-29T03:16:05Z [Term] id: GO:0060569 name: positive regulation of peptide hormone processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010954 ! positive regulation of protein processing is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016486 ! peptide hormone processing relationship: positively_regulates GO:0016486 ! peptide hormone processing created_by: dph creation_date: 2009-04-29T03:22:05Z [Term] id: GO:0060570 name: negative regulation of peptide hormone processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] is_a: GO:0010955 ! negative regulation of protein processing is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0060568 ! regulation of peptide hormone processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016486 ! peptide hormone processing relationship: negatively_regulates GO:0016486 ! peptide hormone processing created_by: dph creation_date: 2009-04-29T03:24:55Z [Term] id: GO:0060571 name: morphogenesis of an epithelial fold namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] synonym: "epithelial folding" EXACT [GOC:dph] synonym: "folding of an epithelial sheet" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium created_by: dph creation_date: 2009-04-30T09:27:17Z [Term] id: GO:0060572 name: morphogenesis of an epithelial bud namespace: biological_process def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] is_a: GO:0060571 ! morphogenesis of an epithelial fold created_by: dph creation_date: 2009-04-30T09:38:35Z [Term] id: GO:0060573 name: cell fate specification involved in pattern specification namespace: biological_process def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb] is_a: GO:0001708 ! cell fate specification intersection_of: GO:0001708 ! cell fate specification intersection_of: part_of GO:0007389 ! pattern specification process relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification created_by: dph creation_date: 2009-05-05T02:19:14Z [Term] id: GO:0060574 name: intestinal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0060576 ! intestinal epithelial cell development created_by: dph creation_date: 2009-05-06T08:10:41Z [Term] id: GO:0060575 name: intestinal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation relationship: part_of GO:0048565 ! digestive tract development created_by: dph creation_date: 2009-05-06T08:17:56Z [Term] id: GO:0060576 name: intestinal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation created_by: dph creation_date: 2009-05-06T08:20:24Z [Term] id: GO:0060577 name: pulmonary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis created_by: dph creation_date: 2009-05-06T08:44:04Z [Term] id: GO:0060578 name: superior vena cava morphogenesis namespace: biological_process def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis created_by: dph creation_date: 2009-05-06T08:47:21Z [Term] id: GO:0060579 name: ventral spinal cord interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] is_a: GO:0048663 ! neuron fate commitment is_a: GO:0060581 ! cell fate commitment involved in pattern specification relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation created_by: dph creation_date: 2009-05-07T12:21:13Z [Term] id: GO:0060580 name: ventral spinal cord interneuron fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] is_a: GO:0048664 ! neuron fate determination is_a: GO:0060582 ! cell fate determination involved in pattern specification relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment created_by: dph creation_date: 2009-05-07T12:24:50Z [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: part_of GO:0007389 ! pattern specification process relationship: part_of GO:0007389 ! pattern specification process created_by: dph creation_date: 2009-05-07T12:40:55Z [Term] id: GO:0060582 name: cell fate determination involved in pattern specification namespace: biological_process def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph] is_a: GO:0001709 ! cell fate determination intersection_of: GO:0001709 ! cell fate determination intersection_of: part_of GO:0007389 ! pattern specification process relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification created_by: dph creation_date: 2009-05-07T12:48:08Z [Term] id: GO:0060583 name: regulation of actin cortical patch localization namespace: biological_process def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb] synonym: "regulation of actin cortical patch localisation" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051666 ! actin cortical patch localization relationship: regulates GO:0051666 ! actin cortical patch localization created_by: dph creation_date: 2009-05-08T01:58:42Z [Term] id: GO:0060584 name: regulation of prostaglandin-endoperoxide synthase activity namespace: biological_process def: "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "regulation of PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity relationship: regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity created_by: dph creation_date: 2009-05-08T02:08:37Z [Term] id: GO:0060585 name: positive regulation of prostaglandin-endoperoxide synthase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of (PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "positive regulation of prostaglandin synthetase activity" EXACT [EC:1.14.99.1] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity relationship: positively_regulates GO:0004666 ! prostaglandin-endoperoxide synthase activity created_by: dph creation_date: 2009-05-08T02:12:34Z [Term] id: GO:0060586 name: multicellular organismal iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0048871 ! multicellular organismal homeostasis is_a: GO:0055072 ! iron ion homeostasis created_by: dph creation_date: 2009-05-08T02:18:21Z [Term] id: GO:0060587 name: regulation of lipoprotein lipid oxidation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0034442 ! regulation of lipoprotein oxidation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034439 ! lipoprotein lipid oxidation relationship: regulates GO:0034439 ! lipoprotein lipid oxidation created_by: dph creation_date: 2009-05-08T02:27:02Z [Term] id: GO:0060588 name: negative regulation of lipoprotein lipid oxidation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0034443 ! negative regulation of lipoprotein oxidation is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation created_by: dph creation_date: 2009-05-08T02:30:49Z [Term] id: GO:0060589 name: nucleoside-triphosphatase regulator activity namespace: molecular_function def: "Modulates the rate of NTP hydrolysis by a NTPase." [GOC:dph, GOC:tb] synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0017111 ! nucleoside-triphosphatase activity created_by: dph creation_date: 2009-05-08T02:49:24Z [Term] id: GO:0060590 name: ATPase regulator activity namespace: molecular_function def: "Modulates the rate of ATP hydrolysis by an ATPase." [GOC:dph, GOC:tb] is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity relationship: regulates GO:0016887 ! ATPase activity created_by: dph creation_date: 2009-05-08T02:49:24Z [Term] id: GO:0060591 name: chondroblast differentiation namespace: biological_process def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development created_by: dph creation_date: 2009-05-11T07:47:36Z [Term] id: GO:0060592 name: mammary gland formation namespace: biological_process def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154] synonym: "mammary bud formation" RELATED [GOC:dph] synonym: "mammary line formation" NARROW [GOC:dph] synonym: "mammary placode formation" NARROW [GOC:dph] synonym: "mammary sprout formation" RELATED [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060443 ! mammary gland morphogenesis created_by: dph creation_date: 2009-05-13T08:47:52Z [Term] id: GO:0060593 name: Wnt signaling pathway involved in mammary gland specification namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] synonym: "Wnt receptor signaling pathway involved in mammary gland specification" EXACT [] synonym: "Wnt receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in mammary gland specification" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0060594 ! mammary gland specification relationship: part_of GO:0060594 ! mammary gland specification created_by: dph creation_date: 2009-05-13T09:41:37Z [Term] id: GO:0060594 name: mammary gland specification namespace: biological_process def: "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph] synonym: "mammary line specification" RELATED [GOC:dph] is_a: GO:0010092 ! specification of animal organ identity is_a: GO:0060592 ! mammary gland formation created_by: dph creation_date: 2009-05-13T10:09:10Z [Term] id: GO:0060595 name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification namespace: biological_process def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] synonym: "fibroblast growth factor receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0060594 ! mammary gland specification relationship: part_of GO:0060594 ! mammary gland specification created_by: dph creation_date: 2009-05-13T10:38:18Z [Term] id: GO:0060596 name: mammary placode formation namespace: biological_process def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0060592 ! mammary gland formation created_by: dph creation_date: 2009-05-13T11:55:20Z [Term] id: GO:0060597 name: obsolete regulation of transcription from RNA polymerase II promoter involved in mammary gland formation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2009-05-13T12:04:53Z [Term] id: GO:0060598 name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154] synonym: "primary mammary duct branching" EXACT [GOC:dph] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching created_by: dph creation_date: 2009-05-13T12:16:29Z [Term] id: GO:0060599 name: lateral sprouting involved in mammary gland duct morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154] synonym: "mammary gland duct secondary branching" EXACT [GOC:dph] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis created_by: dph creation_date: 2009-05-13T12:38:06Z [Term] id: GO:0060600 name: dichotomous subdivision of an epithelial terminal unit namespace: biological_process def: "The process in which an epithelial cord, rod or tube bifurcates at its end." [GOC:dph] synonym: "primary branching of an epithelium" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium created_by: dph creation_date: 2009-05-14T02:14:50Z [Term] id: GO:0060601 name: lateral sprouting from an epithelium namespace: biological_process def: "The process in which a branch forms along the side of an epithelium." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium created_by: dph creation_date: 2009-05-14T02:33:01Z [Term] id: GO:0060602 name: branch elongation of an epithelium namespace: biological_process def: "The growth process in which a branch increases in length from its base to its tip." [GOC:dph] is_a: GO:0003401 ! axis elongation relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium created_by: dph creation_date: 2009-05-14T02:45:44Z [Term] id: GO:0060603 name: mammary gland duct morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0060443 ! mammary gland morphogenesis relationship: part_of GO:0061180 ! mammary gland epithelium development created_by: dph creation_date: 2009-05-15T09:22:25Z [Term] id: GO:0060604 name: mammary gland duct cavitation namespace: biological_process def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154] synonym: "milk duct cavitation" RELATED [GOC:dph] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0060603 ! mammary gland duct morphogenesis created_by: dph creation_date: 2009-05-15T09:34:07Z [Term] id: GO:0060605 name: tube lumen cavitation namespace: biological_process def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph] is_a: GO:0035148 ! tube formation created_by: dph creation_date: 2009-05-15T09:39:49Z [Term] id: GO:0060606 name: tube closure namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph] is_a: GO:0035148 ! tube formation created_by: dph creation_date: 2009-05-15T09:44:07Z [Term] id: GO:0060607 name: cell-cell adhesion involved in sealing an epithelial fold namespace: biological_process def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph] is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0060606 ! tube closure created_by: dph creation_date: 2009-05-15T09:48:49Z [Term] id: GO:0060608 name: cell-cell adhesion involved in neural tube closure namespace: biological_process def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph] is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0001843 ! neural tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: dph creation_date: 2009-05-15T09:56:14Z [Term] id: GO:0060609 name: apoptotic process involved in tube lumen cavitation namespace: biological_process def: "Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in tube lumen cavitation" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0060605 ! tube lumen cavitation relationship: part_of GO:0060605 ! tube lumen cavitation created_by: dph creation_date: 2009-05-15T10:05:39Z [Term] id: GO:0060610 name: mesenchymal cell differentiation involved in mammary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph] synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0030879 ! mammary gland development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2009-05-15T12:17:06Z [Term] id: GO:0060611 name: mammary gland fat development namespace: biological_process def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph] is_a: GO:0060612 ! adipose tissue development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2009-05-15T12:27:57Z [Term] id: GO:0060612 name: adipose tissue development namespace: biological_process def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0048513 ! animal organ development created_by: dph creation_date: 2009-05-15T12:36:28Z [Term] id: GO:0060613 name: fat pad development namespace: biological_process def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph] is_a: GO:0060612 ! adipose tissue development created_by: dph creation_date: 2009-05-15T12:42:08Z [Term] id: GO:0060614 name: negative regulation of mammary gland development in males by androgen receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph] synonym: "negative regulation of mammary gland development in males by androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030521 ! androgen receptor signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: negatively_regulates GO:0030879 ! mammary gland development created_by: dph creation_date: 2009-05-18T08:34:40Z [Term] id: GO:0060615 name: mammary gland bud formation namespace: biological_process def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060648 ! mammary gland bud morphogenesis created_by: dph creation_date: 2009-05-18T08:43:14Z [Term] id: GO:0060616 name: mammary gland cord formation namespace: biological_process def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0060652 ! mammary gland cord morphogenesis created_by: dph creation_date: 2009-05-18T08:57:58Z [Term] id: GO:0060617 name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599] synonym: "positive regulation of mammary placode formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:0110110 ! positive regulation of animal organ morphogenesis relationship: positively_regulates GO:0060596 ! mammary placode formation created_by: dph creation_date: 2009-05-18T09:16:07Z [Term] id: GO:0060618 name: nipple development namespace: biological_process def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2009-05-18T09:29:38Z [Term] id: GO:0060619 name: cell migration involved in mammary placode formation namespace: biological_process def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060596 ! mammary placode formation relationship: part_of GO:0060596 ! mammary placode formation created_by: dph creation_date: 2009-05-18T09:41:49Z [Term] id: GO:0060620 name: regulation of cholesterol import namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:2000909 ! regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070508 ! cholesterol import relationship: regulates GO:0070508 ! cholesterol import created_by: dph creation_date: 2009-05-18T01:41:08Z [Term] id: GO:0060621 name: negative regulation of cholesterol import namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0060620 ! regulation of cholesterol import is_a: GO:2000910 ! negative regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070508 ! cholesterol import relationship: negatively_regulates GO:0070508 ! cholesterol import created_by: dph creation_date: 2009-05-18T01:46:21Z [Term] id: GO:0060622 name: regulation of ascospore wall beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process created_by: dph creation_date: 2009-05-18T02:01:26Z [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030261 ! chromosome condensation relationship: regulates GO:0030261 ! chromosome condensation created_by: dph creation_date: 2009-05-18T02:12:13Z [Term] id: GO:0060624 name: regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] synonym: "regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD [] synonym: "regulation of ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process is_a: GO:0090334 ! regulation of cell wall (1->3)-beta-D-glucan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process relationship: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process created_by: dph creation_date: 2009-05-18T02:18:10Z [Term] id: GO:0060625 name: regulation of protein deneddylation namespace: biological_process alt_id: GO:0060626 def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb] synonym: "regulation of cullin deneddylation" NARROW [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000338 ! protein deneddylation relationship: regulates GO:0000338 ! protein deneddylation created_by: dph creation_date: 2009-05-18T02:22:07Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016192 ! vesicle-mediated transport relationship: regulates GO:0016192 ! vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060628 name: regulation of ER to Golgi vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport relationship: regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:37:00Z [Term] id: GO:0060629 name: regulation of homologous chromosome segregation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0060631 ! regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045143 ! homologous chromosome segregation relationship: regulates GO:0045143 ! homologous chromosome segregation created_by: dph creation_date: 2009-05-18T02:41:02Z [Term] id: GO:0060630 name: obsolete regulation of M/G1 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "regulation of M/G1 transition of mitotic cell cycle" EXACT [] is_obsolete: true created_by: dph creation_date: 2009-05-18T02:48:58Z [Term] id: GO:0060631 name: regulation of meiosis I namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] is_a: GO:0040020 ! regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007127 ! meiosis I relationship: regulates GO:0007127 ! meiosis I created_by: dph creation_date: 2009-05-18T02:55:19Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007018 ! microtubule-based movement relationship: regulates GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060633 name: negative regulation of transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter is_a: GO:2000143 ! negative regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter relationship: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter created_by: dph creation_date: 2009-05-18T03:11:26Z [Term] id: GO:0060634 name: regulation of 4,6-pyruvylated galactose residue biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process created_by: dph creation_date: 2009-05-18T03:15:39Z [Term] id: GO:0060635 name: positive regulation of (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb] synonym: "positive regulation of 1,3-beta-D-glucan biosynthetic process" EXACT [] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process relationship: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process created_by: dph creation_date: 2009-05-18T03:22:44Z [Term] id: GO:0060636 name: negative regulation of (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb] synonym: "negative regulation of 1,3-beta-D-glucan biosynthetic process" EXACT [] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process relationship: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process created_by: dph creation_date: 2009-05-18T03:24:02Z [Term] id: GO:0060637 name: positive regulation of lactation by mesenchymal-epithelial cell signaling namespace: biological_process def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599] synonym: "positive regulation of lactation by mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:1903489 ! positive regulation of lactation created_by: dph creation_date: 2009-05-19T03:39:24Z [Term] id: GO:0060638 name: mesenchymal-epithelial cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling created_by: dph creation_date: 2009-05-19T03:59:05Z [Term] id: GO:0060639 name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph] synonym: "positive regulation of salivary gland formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:0110110 ! positive regulation of animal organ morphogenesis relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis created_by: dph creation_date: 2009-05-20T04:26:43Z [Term] id: GO:0060640 name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph] synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling" RELATED [] synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth is_a: GO:0060638 ! mesenchymal-epithelial cell signaling created_by: dph creation_date: 2009-05-20T04:33:52Z [Term] id: GO:0060641 name: mammary gland duct regression in males namespace: biological_process def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0060603 ! mammary gland duct morphogenesis created_by: dph creation_date: 2009-05-20T04:50:57Z [Term] id: GO:0060642 name: white fat cell differentiation involved in mammary gland fat development namespace: biological_process def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599] is_a: GO:0050872 ! white fat cell differentiation intersection_of: GO:0050872 ! white fat cell differentiation intersection_of: part_of GO:0060611 ! mammary gland fat development relationship: part_of GO:0060611 ! mammary gland fat development created_by: dph creation_date: 2009-05-27T05:50:56Z [Term] id: GO:0060643 name: epithelial cell differentiation involved in mammary gland bud morphogenesis namespace: biological_process def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0060648 ! mammary gland bud morphogenesis relationship: part_of GO:0060615 ! mammary gland bud formation created_by: dph creation_date: 2009-05-29T07:58:13Z [Term] id: GO:0060644 name: mammary gland epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0061180 ! mammary gland epithelium development created_by: dph creation_date: 2009-05-29T08:03:07Z [Term] id: GO:0060645 name: peripheral mammary gland bud epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599] is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis created_by: dph creation_date: 2009-05-29T08:06:16Z [Term] id: GO:0060646 name: internal mammary gland bud epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599] is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis created_by: dph creation_date: 2009-05-29T08:10:48Z [Term] id: GO:0060647 name: mesenchymal cell condensation involved in mammary fat development namespace: biological_process def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: part_of GO:0060611 ! mammary gland fat development relationship: part_of GO:0060611 ! mammary gland fat development created_by: dph creation_date: 2009-05-29T08:33:29Z [Term] id: GO:0060648 name: mammary gland bud morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599] is_a: GO:0060572 ! morphogenesis of an epithelial bud relationship: part_of GO:0060603 ! mammary gland duct morphogenesis created_by: dph creation_date: 2009-05-29T08:42:22Z [Term] id: GO:0060649 name: mammary gland bud elongation namespace: biological_process def: "The process in which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060648 ! mammary gland bud morphogenesis created_by: dph creation_date: 2009-05-29T08:50:39Z [Term] id: GO:0060650 name: epithelial cell proliferation involved in mammary gland bud elongation namespace: biological_process def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599] is_a: GO:0033598 ! mammary gland epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0060649 ! mammary gland bud elongation relationship: part_of GO:0060649 ! mammary gland bud elongation created_by: dph creation_date: 2009-05-29T08:54:54Z [Term] id: GO:0060651 name: regulation of epithelial cell proliferation involved in mammary gland bud elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599] is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation is_a: GO:0048638 ! regulation of developmental growth is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation created_by: dph creation_date: 2009-05-29T08:57:18Z [Term] id: GO:0060652 name: mammary gland cord morphogenesis namespace: biological_process def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599] synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0060603 ! mammary gland duct morphogenesis created_by: dph creation_date: 2009-05-29T09:06:56Z [Term] id: GO:0060653 name: epithelial cell differentiation involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599] synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0060652 ! mammary gland cord morphogenesis relationship: part_of GO:0060652 ! mammary gland cord morphogenesis created_by: dph creation_date: 2009-05-29T09:17:16Z [Term] id: GO:0060654 name: mammary gland cord elongation namespace: biological_process def: "The process in which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599] is_a: GO:0060751 ! branch elongation involved in mammary gland duct branching relationship: part_of GO:0060652 ! mammary gland cord morphogenesis created_by: dph creation_date: 2009-05-29T09:26:15Z [Term] id: GO:0060655 name: branching involved in mammary gland cord morphogenesis namespace: biological_process def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599] is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0060652 ! mammary gland cord morphogenesis relationship: part_of GO:0060652 ! mammary gland cord morphogenesis created_by: dph creation_date: 2009-05-29T09:29:32Z [Term] id: GO:0060656 name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599] synonym: "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis created_by: dph creation_date: 2009-05-29T09:34:31Z [Term] id: GO:0060657 name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599] synonym: "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis relationship: regulates GO:0060654 ! mammary gland cord elongation created_by: dph creation_date: 2009-05-29T09:43:08Z [Term] id: GO:0060658 name: nipple morphogenesis namespace: biological_process def: "The process in which the nipple is generated and organized." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060618 ! nipple development created_by: dph creation_date: 2009-05-29T10:45:44Z [Term] id: GO:0060659 name: nipple sheath formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060658 ! nipple morphogenesis created_by: dph creation_date: 2009-05-29T10:48:39Z [Term] id: GO:0060660 name: epidermis morphogenesis involved in nipple formation namespace: biological_process def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599] is_a: GO:0048730 ! epidermis morphogenesis intersection_of: GO:0048730 ! epidermis morphogenesis intersection_of: part_of GO:0060658 ! nipple morphogenesis relationship: part_of GO:0060658 ! nipple morphogenesis created_by: dph creation_date: 2009-05-29T11:04:04Z [Term] id: GO:0060661 name: submandibular salivary gland formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007435 ! salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T08:07:16Z [Term] id: GO:0060662 name: salivary gland cavitation namespace: biological_process def: "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph] synonym: "salivary gland invagination" EXACT [] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0007435 ! salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T08:22:55Z [Term] id: GO:0060663 name: apoptotic process involved in salivary gland cavitation namespace: biological_process def: "Any apoptotic process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, GOC:mtg_apoptosis, PMID:17336109] synonym: "apoptosis involved in salivary gland cavitation" NARROW [] is_a: GO:0060609 ! apoptotic process involved in tube lumen cavitation intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0060662 ! salivary gland cavitation relationship: part_of GO:0060662 ! salivary gland cavitation created_by: dph creation_date: 2009-06-01T08:27:16Z [Term] id: GO:0060664 name: epithelial cell proliferation involved in salivary gland morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0007435 ! salivary gland morphogenesis relationship: part_of GO:0007435 ! salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T08:36:13Z [Term] id: GO:0060665 name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109] synonym: "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling" EXACT [GOC:mah] is_a: GO:0060638 ! mesenchymal-epithelial cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T08:42:36Z [Term] id: GO:0060666 name: dichotomous subdivision of terminal units involved in salivary gland branching namespace: biological_process def: "The process in which a salivary epithelial cord bifurcates at its end." [GOC:dph] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: part_of GO:0060445 ! branching involved in salivary gland morphogenesis relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T09:38:40Z [Term] id: GO:0060667 name: branch elongation involved in salivary gland morphogenesis namespace: biological_process def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium intersection_of: GO:0060602 ! branch elongation of an epithelium intersection_of: part_of GO:0007435 ! salivary gland morphogenesis relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T09:42:13Z [Term] id: GO:0060668 name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph] synonym: "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0035426 ! extracellular matrix-cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-01T09:47:56Z [Term] id: GO:0060669 name: embryonic placenta morphogenesis namespace: biological_process def: "The process in which the embryonic placenta is generated and organized." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-02T09:33:37Z [Term] id: GO:0060670 name: branching involved in labyrinthine layer morphogenesis namespace: biological_process def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0060713 ! labyrinthine layer morphogenesis relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis created_by: dph creation_date: 2009-06-02T10:40:40Z [Term] id: GO:0060671 name: epithelial cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0001892 ! embryonic placenta development relationship: part_of GO:0060711 ! labyrinthine layer development created_by: dph creation_date: 2009-06-02T11:40:52Z [Term] id: GO:0060672 name: epithelial cell morphogenesis involved in placental branching namespace: biological_process def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0003382 ! epithelial cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060670 ! branching involved in labyrinthine layer morphogenesis relationship: part_of GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-06-02T12:44:52Z [Term] id: GO:0060673 name: cell-cell signaling involved in placenta development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377] synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0022414 ! reproductive process intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0001890 ! placenta development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-02T12:58:03Z [Term] id: GO:0060674 name: placenta blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377] is_a: GO:0001568 ! blood vessel development is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0001890 ! placenta development created_by: dph creation_date: 2009-06-02T01:09:43Z [Term] id: GO:0060675 name: ureteric bud morphogenesis namespace: biological_process def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis relationship: part_of GO:0001657 ! ureteric bud development created_by: dph creation_date: 2009-06-02T01:31:41Z [Term] id: GO:0060676 name: ureteric bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378] is_a: GO:0072172 ! mesonephric tubule formation relationship: part_of GO:0060675 ! ureteric bud morphogenesis created_by: dph creation_date: 2009-06-02T01:47:23Z [Term] id: GO:0060677 name: ureteric bud elongation namespace: biological_process def: "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated." [GOC:dph, PMID:16916378] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060675 ! ureteric bud morphogenesis created_by: dph creation_date: 2009-06-02T02:13:29Z [Term] id: GO:0060678 name: dichotomous subdivision of terminal units involved in ureteric bud branching namespace: biological_process def: "The process in which a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378] synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378] is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: dph creation_date: 2009-06-02T02:18:17Z [Term] id: GO:0060679 name: trifid subdivision of terminal units involved in ureteric bud branching namespace: biological_process def: "The process in which a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: dph creation_date: 2009-06-02T02:37:42Z [Term] id: GO:0060680 name: lateral sprouting involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378] is_a: GO:0060601 ! lateral sprouting from an epithelium intersection_of: GO:0060601 ! lateral sprouting from an epithelium intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: dph creation_date: 2009-06-02T02:44:27Z [Term] id: GO:0060681 name: branch elongation involved in ureteric bud branching namespace: biological_process def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378] is_a: GO:0060602 ! branch elongation of an epithelium intersection_of: GO:0060602 ! branch elongation of an epithelium intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: part_of GO:0060677 ! ureteric bud elongation created_by: dph creation_date: 2009-06-02T02:52:55Z [Term] id: GO:0060682 name: primary ureteric bud growth namespace: biological_process def: "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060677 ! ureteric bud elongation created_by: dph creation_date: 2009-06-02T02:56:01Z [Term] id: GO:0060683 name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345] synonym: "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling" EXACT [GOC:mah] is_a: GO:0060684 ! epithelial-mesenchymal cell signaling is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-03T06:30:56Z [Term] id: GO:0060684 name: epithelial-mesenchymal cell signaling namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling created_by: dph creation_date: 2009-06-03T06:36:46Z [Term] id: GO:0060685 name: regulation of prostatic bud formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060513 ! prostatic bud formation relationship: regulates GO:0060513 ! prostatic bud formation created_by: dph creation_date: 2009-06-05T12:29:26Z [Term] id: GO:0060686 name: negative regulation of prostatic bud formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0060685 ! regulation of prostatic bud formation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060513 ! prostatic bud formation relationship: negatively_regulates GO:0060513 ! prostatic bud formation created_by: dph creation_date: 2009-06-05T12:35:25Z [Term] id: GO:0060687 name: regulation of branching involved in prostate gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060442 ! branching involved in prostate gland morphogenesis relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis created_by: dph creation_date: 2009-06-05T12:37:14Z [Term] id: GO:0060688 name: regulation of morphogenesis of a branching structure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001763 ! morphogenesis of a branching structure relationship: regulates GO:0001763 ! morphogenesis of a branching structure created_by: dph creation_date: 2009-06-05T12:41:44Z [Term] id: GO:0060689 name: cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0007431 ! salivary gland development relationship: part_of GO:0007431 ! salivary gland development created_by: dph creation_date: 2009-06-08T01:01:35Z [Term] id: GO:0060690 name: epithelial cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0007431 ! salivary gland development created_by: dph creation_date: 2009-06-08T01:04:19Z [Term] id: GO:0060691 name: epithelial cell maturation involved in salivary gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0002070 ! epithelial cell maturation intersection_of: part_of GO:0007431 ! salivary gland development relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development created_by: dph creation_date: 2009-06-08T01:06:00Z [Term] id: GO:0060692 name: mesenchymal cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0007431 ! salivary gland development created_by: dph creation_date: 2009-06-08T01:08:44Z [Term] id: GO:0060693 name: regulation of branching involved in salivary gland morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060445 ! branching involved in salivary gland morphogenesis relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis created_by: dph creation_date: 2009-06-08T01:14:44Z [Term] id: GO:0060694 name: regulation of cholesterol transporter activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032371 ! regulation of sterol transport is_a: GO:0110112 ! regulation of lipid transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120020 ! cholesterol transfer activity relationship: regulates GO:0120020 ! cholesterol transfer activity created_by: dph creation_date: 2009-06-08T02:05:27Z [Term] id: GO:0060695 name: negative regulation of cholesterol transporter activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0060694 ! regulation of cholesterol transporter activity is_a: GO:0110114 ! negative regulation of lipid transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120020 ! cholesterol transfer activity relationship: negatively_regulates GO:0120020 ! cholesterol transfer activity created_by: dph creation_date: 2009-06-08T02:08:34Z [Term] id: GO:0060696 name: regulation of phospholipid catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009395 ! phospholipid catabolic process relationship: regulates GO:0009395 ! phospholipid catabolic process created_by: dph creation_date: 2009-06-08T02:25:45Z [Term] id: GO:0060697 name: positive regulation of phospholipid catabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009395 ! phospholipid catabolic process relationship: positively_regulates GO:0009395 ! phospholipid catabolic process created_by: dph creation_date: 2009-06-08T02:28:38Z [Term] id: GO:0060698 name: endoribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0008428 ! ribonuclease inhibitor activity relationship: negatively_regulates GO:0004521 ! endoribonuclease activity relationship: part_of GO:0060702 ! negative regulation of endoribonuclease activity created_by: dph creation_date: 2009-06-08T02:37:19Z [Term] id: GO:0060699 name: regulation of endoribonuclease activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0060700 ! regulation of ribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004521 ! endoribonuclease activity relationship: regulates GO:0004521 ! endoribonuclease activity created_by: dph creation_date: 2009-06-08T02:43:10Z [Term] id: GO:0060700 name: regulation of ribonuclease activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004540 ! ribonuclease activity relationship: regulates GO:0004540 ! ribonuclease activity created_by: dph creation_date: 2009-06-08T02:45:46Z [Term] id: GO:0060701 name: negative regulation of ribonuclease activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:0060700 ! regulation of ribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004540 ! ribonuclease activity relationship: negatively_regulates GO:0004540 ! ribonuclease activity created_by: dph creation_date: 2009-06-08T02:49:46Z [Term] id: GO:0060702 name: negative regulation of endoribonuclease activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] is_a: GO:0060699 ! regulation of endoribonuclease activity is_a: GO:0060701 ! negative regulation of ribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004521 ! endoribonuclease activity relationship: negatively_regulates GO:0004521 ! endoribonuclease activity created_by: dph creation_date: 2009-06-08T02:52:27Z [Term] id: GO:0060703 name: deoxyribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb] synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004536 ! deoxyribonuclease activity relationship: part_of GO:0032076 ! negative regulation of deoxyribonuclease activity created_by: dph creation_date: 2009-06-08T03:00:35Z [Term] id: GO:0060704 name: acinar cell differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph, GOC:tb] is_a: GO:0060690 ! epithelial cell differentiation involved in salivary gland development is_a: GO:0090425 ! acinar cell differentiation intersection_of: GO:0090425 ! acinar cell differentiation intersection_of: part_of GO:0007431 ! salivary gland development created_by: dph creation_date: 2009-06-09T09:32:46Z [Term] id: GO:0060705 name: neuron differentiation involved in salivary gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060689 ! cell differentiation involved in salivary gland development intersection_of: GO:0030182 ! neuron differentiation intersection_of: part_of GO:0007431 ! salivary gland development created_by: dph creation_date: 2009-06-09T09:35:52Z [Term] id: GO:0060706 name: cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0001892 ! embryonic placenta development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-09T10:26:42Z [Term] id: GO:0060707 name: trophoblast giant cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-06-09T10:32:12Z [Term] id: GO:0060708 name: spongiotrophoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175] synonym: "spongiotrophoblast cell differentiation" EXACT [GOC:cjm] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060712 ! spongiotrophoblast layer development created_by: dph creation_date: 2009-06-09T10:38:10Z [Term] id: GO:0060709 name: glycogen cell differentiation involved in embryonic placenta development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060712 ! spongiotrophoblast layer development created_by: dph creation_date: 2009-06-09T10:41:08Z [Term] id: GO:0060710 name: chorio-allantoic fusion namespace: biological_process def: "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois." [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis created_by: dph creation_date: 2009-06-09T03:24:27Z [Term] id: GO:0060711 name: labyrinthine layer development namespace: biological_process def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-09T03:27:43Z [Term] id: GO:0060712 name: spongiotrophoblast layer development namespace: biological_process def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph] is_a: GO:0009888 ! tissue development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-09T03:33:40Z [Term] id: GO:0060713 name: labyrinthine layer morphogenesis namespace: biological_process def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060669 ! embryonic placenta morphogenesis relationship: part_of GO:0060711 ! labyrinthine layer development created_by: dph creation_date: 2009-06-10T08:10:19Z [Term] id: GO:0060714 name: labyrinthine layer formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis created_by: dph creation_date: 2009-06-10T08:13:14Z [Term] id: GO:0060715 name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development namespace: biological_process def: "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph] is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: part_of GO:0060711 ! labyrinthine layer development created_by: dph creation_date: 2009-06-11T08:56:18Z [Term] id: GO:0060716 name: labyrinthine layer blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph] is_a: GO:0048568 ! embryonic organ development is_a: GO:0048608 ! reproductive structure development is_a: GO:0060674 ! placenta blood vessel development relationship: part_of GO:0060711 ! labyrinthine layer development created_by: dph creation_date: 2009-06-11T09:04:38Z [Term] id: GO:0060717 name: chorion development namespace: biological_process def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph] is_a: GO:1903867 ! extraembryonic membrane development created_by: dph creation_date: 2009-06-11T02:37:50Z [Term] id: GO:0060718 name: chorionic trophoblast cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060717 ! chorion development created_by: dph creation_date: 2009-06-11T02:48:27Z [Term] id: GO:0060719 name: chorionic trophoblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation created_by: dph creation_date: 2009-06-11T02:58:45Z [Term] id: GO:0060720 name: spongiotrophoblast cell proliferation namespace: biological_process def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph] is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth created_by: dph creation_date: 2009-06-11T09:50:35Z [Term] id: GO:0060721 name: regulation of spongiotrophoblast cell proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060720 ! spongiotrophoblast cell proliferation relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation created_by: dph creation_date: 2009-06-11T09:57:27Z [Term] id: GO:0060722 name: cell proliferation involved in embryonic placenta development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph] is_a: GO:0008283 ! cell population proliferation is_a: GO:0022414 ! reproductive process intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001892 ! embryonic placenta development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-12T12:46:04Z [Term] id: GO:0060723 name: regulation of cell proliferation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development created_by: dph creation_date: 2009-06-12T12:50:23Z [Term] id: GO:0060724 name: coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: molecular_function def: "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0015026 ! coreceptor activity intersection_of: GO:0015026 ! coreceptor activity intersection_of: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway created_by: dph creation_date: 2009-06-12T01:06:08Z [Term] id: GO:0060725 name: regulation of coreceptor activity namespace: biological_process def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015026 ! coreceptor activity relationship: regulates GO:0015026 ! coreceptor activity created_by: dph creation_date: 2009-06-12T01:20:11Z [Term] id: GO:0060726 name: regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0060725 ! regulation of coreceptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway relationship: regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway created_by: dph creation_date: 2009-06-12T01:25:20Z [Term] id: GO:0060727 name: positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway relationship: positively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway created_by: dph creation_date: 2009-06-12T01:30:50Z [Term] id: GO:0060728 name: negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] synonym: "negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway relationship: negatively_regulates GO:0060724 ! coreceptor activity involved in epidermal growth factor receptor signaling pathway created_by: dph creation_date: 2009-06-12T01:32:38Z [Term] id: GO:0060729 name: intestinal epithelial structure maintenance namespace: biological_process def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb] synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb] is_a: GO:0030277 ! maintenance of gastrointestinal epithelium created_by: dph creation_date: 2009-06-12T01:44:52Z [Term] id: GO:0060730 name: regulation of intestinal epithelial structure maintenance namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060729 ! intestinal epithelial structure maintenance relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance created_by: dph creation_date: 2009-06-12T01:49:34Z [Term] id: GO:0060731 name: positive regulation of intestinal epithelial structure maintenance namespace: biological_process def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb] is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance created_by: dph creation_date: 2009-06-12T01:51:50Z [Term] id: GO:0060732 name: positive regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process created_by: dph creation_date: 2009-06-12T01:58:23Z [Term] id: GO:0060733 name: regulation of eIF2 alpha phosphorylation by amino acid starvation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation." [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0034198 ! cellular response to amino acid starvation is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation created_by: dph creation_date: 2009-06-12T02:08:50Z [Term] id: GO:0060734 name: regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb] synonym: "regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress" EXACT [] synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb] synonym: "regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress relationship: regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress created_by: dph creation_date: 2009-06-12T02:15:16Z [Term] id: GO:0060735 name: regulation of eIF2 alpha phosphorylation by dsRNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb] synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph] synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0080135 ! regulation of cellular response to stress relationship: part_of GO:0071359 ! cellular response to dsRNA relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation created_by: dph creation_date: 2009-06-12T02:27:14Z [Term] id: GO:0060736 name: prostate gland growth namespace: biological_process def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035265 ! organ growth relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-06-15T09:21:52Z [Term] id: GO:0060737 name: prostate gland morphogenetic growth namespace: biological_process def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph] synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis is_a: GO:0060736 ! prostate gland growth intersection_of: GO:0060736 ! prostate gland growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060512 ! prostate gland morphogenesis created_by: dph creation_date: 2009-06-15T09:24:40Z [Term] id: GO:0060738 name: epithelial-mesenchymal signaling involved in prostate gland development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph] synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-06-15T09:31:31Z [Term] id: GO:0060739 name: mesenchymal-epithelial cell signaling involved in prostate gland development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-06-15T09:35:08Z [Term] id: GO:0060740 name: prostate gland epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0060512 ! prostate gland morphogenesis created_by: dph creation_date: 2009-06-16T09:23:22Z [Term] id: GO:0060741 name: prostate gland stromal morphogenesis namespace: biological_process def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060512 ! prostate gland morphogenesis relationship: part_of GO:0061448 ! connective tissue development created_by: dph creation_date: 2009-06-16T09:27:01Z [Term] id: GO:0060742 name: epithelial cell differentiation involved in prostate gland development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-06-16T09:32:34Z [Term] id: GO:0060743 name: epithelial cell maturation involved in prostate gland development namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] synonym: "prostate gland epithelial cell development" EXACT [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0002070 ! epithelial cell maturation intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development created_by: dph creation_date: 2009-06-16T09:34:42Z [Term] id: GO:0060744 name: mammary gland branching involved in thelarche namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859] synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis intersection_of: GO:0060444 ! branching involved in mammary gland duct morphogenesis intersection_of: part_of GO:0042695 ! thelarche relationship: part_of GO:0042695 ! thelarche created_by: dph creation_date: 2009-06-22T08:12:17Z [Term] id: GO:0060745 name: mammary gland branching involved in pregnancy namespace: biological_process def: "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060135 ! maternal process involved in female pregnancy is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis created_by: dph creation_date: 2009-06-22T08:25:19Z [Term] id: GO:0060746 name: parental behavior namespace: biological_process def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph] is_a: GO:0019098 ! reproductive behavior created_by: dph creation_date: 2009-06-22T09:05:26Z [Term] id: GO:0060747 name: oral incubation namespace: biological_process def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph] is_a: GO:0060746 ! parental behavior created_by: dph creation_date: 2009-06-22T09:08:58Z [Term] id: GO:0060748 name: tertiary branching involved in mammary gland duct morphogenesis namespace: biological_process def: "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy created_by: dph creation_date: 2009-06-22T10:44:51Z [Term] id: GO:0060749 name: mammary gland alveolus development namespace: biological_process def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061377 ! mammary gland lobule development created_by: dph creation_date: 2009-06-22T10:52:12Z [Term] id: GO:0060750 name: epithelial cell proliferation involved in mammary gland duct elongation namespace: biological_process def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph] is_a: GO:0033598 ! mammary gland epithelial cell proliferation intersection_of: GO:0033598 ! mammary gland epithelial cell proliferation intersection_of: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching created_by: dph creation_date: 2009-06-22T10:58:12Z [Term] id: GO:0060751 name: branch elongation involved in mammary gland duct branching namespace: biological_process def: "The developmental growth process in which a branch of a mammary gland duct elongates." [GOC:dph] synonym: "mammary gland duct branch elongation" EXACT [GOC:dph] is_a: GO:0060602 ! branch elongation of an epithelium intersection_of: GO:0060602 ! branch elongation of an epithelium intersection_of: part_of GO:0060603 ! mammary gland duct morphogenesis relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis created_by: dph creation_date: 2009-06-22T11:02:44Z [Term] id: GO:0060752 name: intestinal phytosterol absorption namespace: biological_process def: "Any process in which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0098856 ! intestinal lipid absorption created_by: dph creation_date: 2009-06-22T02:08:43Z [Term] id: GO:0060753 name: regulation of mast cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002551 ! mast cell chemotaxis relationship: regulates GO:0002551 ! mast cell chemotaxis created_by: dph creation_date: 2009-06-22T02:36:06Z [Term] id: GO:0060754 name: positive regulation of mast cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002551 ! mast cell chemotaxis relationship: positively_regulates GO:0002551 ! mast cell chemotaxis created_by: dph creation_date: 2009-06-22T02:38:19Z [Term] id: GO:0060755 name: negative regulation of mast cell chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0060753 ! regulation of mast cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002551 ! mast cell chemotaxis relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis created_by: dph creation_date: 2009-06-22T02:40:58Z [Term] id: GO:0060756 name: foraging behavior namespace: biological_process def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb] is_a: GO:0007610 ! behavior created_by: dph creation_date: 2009-06-22T02:46:25Z [Term] id: GO:0060757 name: adult foraging behavior namespace: biological_process def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb] is_a: GO:0060756 ! foraging behavior created_by: dph creation_date: 2009-06-22T02:50:56Z [Term] id: GO:0060758 name: foraging behavior by probing substrate namespace: biological_process def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb] is_a: GO:0060756 ! foraging behavior created_by: dph creation_date: 2009-06-22T02:53:09Z [Term] id: GO:0060759 name: regulation of response to cytokine stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034097 ! response to cytokine relationship: regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:56:12Z [Term] id: GO:0060760 name: positive regulation of response to cytokine stimulus namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034097 ! response to cytokine relationship: positively_regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:58:04Z [Term] id: GO:0060761 name: negative regulation of response to cytokine stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034097 ! response to cytokine relationship: negatively_regulates GO:0034097 ! response to cytokine created_by: dph creation_date: 2009-06-22T02:59:57Z [Term] id: GO:0060762 name: regulation of branching involved in mammary gland duct morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis created_by: dph creation_date: 2009-06-22T05:20:33Z [Term] id: GO:0060763 name: mammary duct terminal end bud growth namespace: biological_process def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060603 ! mammary gland duct morphogenesis created_by: dph creation_date: 2009-07-06T07:33:50Z [Term] id: GO:0060764 name: cell-cell signaling involved in mammary gland development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph] synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0030879 ! mammary gland development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2009-07-06T09:24:53Z [Term] id: GO:0060765 name: regulation of androgen receptor signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] synonym: "regulation of androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030521 ! androgen receptor signaling pathway relationship: regulates GO:0030521 ! androgen receptor signaling pathway created_by: dph creation_date: 2009-07-06T11:07:38Z [Term] id: GO:0060766 name: negative regulation of androgen receptor signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] synonym: "negative regulation of androgen receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:0060765 ! regulation of androgen receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030521 ! androgen receptor signaling pathway relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway created_by: dph creation_date: 2009-07-06T11:09:36Z [Term] id: GO:0060767 name: epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0022414 ! reproductive process is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-07-08T07:32:34Z [Term] id: GO:0060768 name: regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development created_by: dph creation_date: 2009-07-08T07:34:56Z [Term] id: GO:0060769 name: positive regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development created_by: dph creation_date: 2009-07-08T07:38:02Z [Term] id: GO:0060770 name: negative regulation of epithelial cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development created_by: dph creation_date: 2009-07-08T07:40:27Z [Term] id: GO:0060771 name: phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009956 ! radial pattern formation created_by: dph creation_date: 2009-07-25T06:20:33Z [Term] id: GO:0060772 name: leaf phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060771 ! phyllotactic patterning created_by: dph creation_date: 2009-07-25T06:27:15Z [Term] id: GO:0060773 name: flower phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060771 ! phyllotactic patterning created_by: dph creation_date: 2009-07-25T06:28:38Z [Term] id: GO:0060774 name: auxin mediated signaling pathway involved in phyllotactic patterning namespace: biological_process def: "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "auxin mediated signalling pathway involved in phyllotactic patterning" EXACT [GOC:mah] is_a: GO:0009734 ! auxin-activated signaling pathway intersection_of: GO:0009734 ! auxin-activated signaling pathway intersection_of: part_of GO:0060771 ! phyllotactic patterning relationship: part_of GO:0060771 ! phyllotactic patterning created_by: dph creation_date: 2009-07-25T06:31:13Z [Term] id: GO:0060775 name: planar cell polarity pathway involved in gastrula mediolateral intercalation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: part_of GO:0060031 ! mediolateral intercalation created_by: dph creation_date: 2009-07-25T06:52:50Z [Term] id: GO:0060776 name: simple leaf morphogenesis namespace: biological_process def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009965 ! leaf morphogenesis created_by: dph creation_date: 2009-07-25T07:08:44Z [Term] id: GO:0060777 name: compound leaf morphogenesis namespace: biological_process def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009965 ! leaf morphogenesis created_by: dph creation_date: 2009-07-25T07:12:30Z [Term] id: GO:0060778 name: primary leaflet morphogenesis namespace: biological_process def: "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis created_by: dph creation_date: 2009-07-25T07:15:48Z [Term] id: GO:0060779 name: secondary leaflet morphogenesis namespace: biological_process def: "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis created_by: dph creation_date: 2009-07-25T07:19:02Z [Term] id: GO:0060780 name: intercalary leaflet morphogenesis namespace: biological_process def: "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060794 ! leaflet morphogenesis created_by: dph creation_date: 2009-07-25T07:20:46Z [Term] id: GO:0060781 name: mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0022414 ! reproductive process intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: part_of GO:0030850 ! prostate gland development relationship: part_of GO:0030850 ! prostate gland development created_by: dph creation_date: 2009-07-28T11:50:56Z [Term] id: GO:0060782 name: regulation of mesenchymal cell proliferation involved in prostate gland development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development created_by: dph creation_date: 2009-07-28T11:54:20Z [Term] id: GO:0060783 name: mesenchymal smoothened signaling pathway involved in prostate gland development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011] synonym: "mesenchymal hedgehog signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] synonym: "mesenchymal hh signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] synonym: "mesenchymal smoothened signalling pathway involved in prostate gland development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0022414 ! reproductive process is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development created_by: dph creation_date: 2009-07-28T11:57:59Z [Term] id: GO:0060784 name: regulation of cell proliferation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue created_by: dph creation_date: 2009-07-31T01:46:28Z [Term] id: GO:0060785 name: regulation of apoptosis involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0042981 ! regulation of apoptotic process intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue created_by: dph creation_date: 2009-07-31T01:49:54Z [Term] id: GO:0060786 name: regulation of cell differentiation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0045595 ! regulation of cell differentiation intersection_of: part_of GO:0001894 ! tissue homeostasis relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue created_by: dph creation_date: 2009-07-31T01:55:19Z [Term] id: GO:0060787 name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: positively_regulates GO:0090018 ! posterior neural plate formation created_by: dph creation_date: 2009-08-04T09:48:31Z [Term] id: GO:0060788 name: ectodermal placode formation namespace: biological_process def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0071697 ! ectodermal placode morphogenesis created_by: dph creation_date: 2009-08-04T12:15:57Z [Term] id: GO:0060789 name: hair follicle placode formation namespace: biological_process def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0001942 ! hair follicle development created_by: dph creation_date: 2009-08-04T12:18:26Z [Term] id: GO:0060790 name: tooth placode formation namespace: biological_process def: "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth created_by: dph creation_date: 2009-08-04T12:21:47Z [Term] id: GO:0060791 name: sebaceous gland placode formation namespace: biological_process def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048733 ! sebaceous gland development created_by: dph creation_date: 2009-08-04T12:23:09Z [Term] id: GO:0060792 name: sweat gland development namespace: biological_process def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048732 ! gland development created_by: dph creation_date: 2009-08-04T12:35:12Z [Term] id: GO:0060793 name: sweat gland placode formation namespace: biological_process def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0060792 ! sweat gland development created_by: dph creation_date: 2009-08-04T12:38:10Z [Term] id: GO:0060794 name: leaflet morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the leaflet are generated and organized." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060777 ! compound leaf morphogenesis created_by: dph creation_date: 2009-08-04T02:58:14Z [Term] id: GO:0060795 name: cell fate commitment involved in formation of primary germ layer namespace: biological_process def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: part_of GO:0001704 ! formation of primary germ layer relationship: part_of GO:0001704 ! formation of primary germ layer created_by: dph creation_date: 2009-08-04T03:11:22Z [Term] id: GO:0060796 name: regulation of transcription involved in primary germ layer cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer created_by: dph creation_date: 2009-08-04T03:40:21Z [Term] id: GO:0060797 name: transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer created_by: dph creation_date: 2009-08-04T03:41:44Z [Term] id: GO:0060798 name: transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0007501 ! mesodermal cell fate specification created_by: dph creation_date: 2009-08-06T11:16:11Z [Term] id: GO:0060799 name: transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0001714 ! endodermal cell fate specification relationship: part_of GO:0001714 ! endodermal cell fate specification created_by: dph creation_date: 2009-08-06T11:24:01Z [Term] id: GO:0060800 name: regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-08-06T01:20:25Z [Term] id: GO:0060801 name: negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway namespace: biological_process def: "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway" EXACT [GOC:mah] is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-08-06T01:24:24Z [Term] id: GO:0060802 name: epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification namespace: biological_process def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: dph creation_date: 2009-08-06T01:36:13Z [Term] id: GO:0060803 name: BMP signaling pathway involved in mesodermal cell fate specification namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "BMP signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0060796 ! regulation of transcription involved in primary germ layer cell fate commitment intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0007501 ! mesodermal cell fate specification relationship: part_of GO:0007501 ! mesodermal cell fate specification created_by: dph creation_date: 2009-08-06T01:47:39Z [Term] id: GO:0060804 name: positive regulation of Wnt signaling pathway by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of WNT receptor signaling pathway by BMP signaling pathway" EXACT [GOC:bf] synonym: "positive regulation of Wnt receptor signaling pathway by BMP signaling pathway" EXACT [] synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: positively_regulates GO:0016055 ! Wnt signaling pathway created_by: dph creation_date: 2009-08-06T01:52:48Z [Term] id: GO:0060805 name: negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-08-06T01:58:25Z [Term] id: GO:0060806 name: negative regulation of cell differentiation involved in embryonic placenta development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development created_by: dph creation_date: 2009-08-06T02:02:18Z [Term] id: GO:0060807 name: regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060796 ! regulation of transcription involved in primary germ layer cell fate commitment relationship: part_of GO:0001714 ! endodermal cell fate specification created_by: dph creation_date: 2009-08-06T02:14:09Z [Term] id: GO:0060808 name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation created_by: dph creation_date: 2009-08-06T02:32:53Z [Term] id: GO:0060809 name: mesodermal to mesenchymal transition involved in gastrulation namespace: biological_process def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007369 ! gastrulation created_by: dph creation_date: 2009-08-06T02:42:09Z [Term] id: GO:0060810 name: intracellular mRNA localization involved in pattern specification process namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "intracellular mRNA localisation involved in pattern specification process" EXACT [GOC:mah] is_a: GO:0008298 ! intracellular mRNA localization intersection_of: GO:0008298 ! intracellular mRNA localization intersection_of: part_of GO:0007389 ! pattern specification process relationship: part_of GO:0007389 ! pattern specification process created_by: dph creation_date: 2009-08-07T09:19:58Z [Term] id: GO:0060811 name: intracellular mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "intracellular mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process intersection_of: GO:0008298 ! intracellular mRNA localization intersection_of: part_of GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: dph creation_date: 2009-08-07T09:26:22Z [Term] id: GO:0060812 name: orthodenticle mRNA localization namespace: biological_process def: "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "orthodenticle mRNA localisation" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification created_by: dph creation_date: 2009-08-07T09:39:01Z [Term] id: GO:0060813 name: anterior mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "anterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification created_by: dph creation_date: 2009-08-07T09:51:47Z [Term] id: GO:0060814 name: posterior mRNA localization involved in anterior/posterior axis specification namespace: biological_process def: "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "posterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification created_by: dph creation_date: 2009-08-07T09:54:54Z [Term] id: GO:0060815 name: regulation of translation involved in anterior/posterior axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0006417 ! regulation of translation intersection_of: part_of GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: dph creation_date: 2009-08-07T10:02:31Z [Term] id: GO:0060816 name: random inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: dph creation_date: 2009-08-11T10:47:30Z [Term] id: GO:0060817 name: inactivation of paternal X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: dph creation_date: 2009-08-11T10:50:20Z [Term] id: GO:0060818 name: inactivation of paternal X chromosome by genetic imprinting namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060817 ! inactivation of paternal X chromosome is_a: GO:0060819 ! inactivation of X chromosome by genetic imprinting created_by: dph creation_date: 2009-08-11T10:52:31Z [Term] id: GO:0060819 name: inactivation of X chromosome by genetic imprinting namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006349 ! regulation of gene expression by genetic imprinting is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: dph creation_date: 2009-08-11T10:56:06Z [Term] id: GO:0060820 name: inactivation of X chromosome by heterochromatin assembly namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "inactivation of X chromosome by heterochromatin formation" EXACT [] is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome is_a: GO:0031507 ! heterochromatin assembly created_by: dph creation_date: 2009-08-11T10:58:06Z [Term] id: GO:0060821 name: inactivation of X chromosome by DNA methylation namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: dph creation_date: 2009-08-11T11:02:19Z [Term] id: GO:0060822 name: transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification" EXACT [GOC:mah] is_a: GO:0060798 ! transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0048327 ! axial mesodermal cell fate specification relationship: part_of GO:0048327 ! axial mesodermal cell fate specification created_by: dph creation_date: 2009-08-11T12:55:33Z [Term] id: GO:0060823 name: canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling] synonym: "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization created_by: dph creation_date: 2009-08-11T01:22:42Z [Term] id: GO:0060824 name: retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization created_by: dph creation_date: 2009-08-11T01:30:57Z [Term] id: GO:0060825 name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization created_by: dph creation_date: 2009-08-11T01:40:03Z [Term] id: GO:0060826 name: transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization created_by: dph creation_date: 2009-08-11T01:43:29Z [Term] id: GO:0060827 name: regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [] synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation relationship: regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation created_by: dph creation_date: 2009-08-11T01:48:52Z [Term] id: GO:0060828 name: regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035411 alt_id: GO:0035412 def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] comment: Merged regulation of catenin import into nucleus into regulation of canonical Wnt signaling pathway, see https://github.com/geneontology/go-ontology/issues/15268 and catenin import into nucleus https://github.com/geneontology/go-ontology/issues/13686 synonym: "catenin import into nucleus" NARROW [] synonym: "regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "regulation of catenin import into nucleus" NARROW [] synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060070 ! canonical Wnt signaling pathway relationship: regulates GO:0060070 ! canonical Wnt signaling pathway created_by: dph creation_date: 2009-08-11T01:54:47Z [Term] id: GO:0060829 name: negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern" EXACT [] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern" EXACT [GOC:signaling] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0060827 ! regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation relationship: negatively_regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation created_by: dph creation_date: 2009-08-11T01:58:33Z [Term] id: GO:0060830 name: ciliary receptor clustering involved in smoothened signaling pathway namespace: biological_process def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:cilia, GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "ciliary receptor clustering involved in hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "ciliary receptor clustering involved in hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "ciliary receptor clustering involved in smoothened signalling pathway" EXACT [GOC:mah] is_a: GO:0043113 ! receptor clustering relationship: occurs_in GO:0005929 ! cilium relationship: part_of GO:0007224 ! smoothened signaling pathway created_by: dph creation_date: 2009-08-11T02:06:33Z [Term] id: GO:0060831 name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway intersection_of: GO:0007224 ! smoothened signaling pathway intersection_of: part_of GO:0021904 ! dorsal/ventral neural tube patterning relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning created_by: dph creation_date: 2009-08-11T02:12:58Z [Term] id: GO:0060832 name: oocyte animal/vegetal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007309 ! oocyte axis specification created_by: dph creation_date: 2009-08-11T03:11:06Z [Term] id: GO:0060833 name: Wnt signaling pathway involved in animal/vegetal axis specification namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Wnt receptor signaling pathway involved in animal/vegetal axis specification" EXACT [] synonym: "Wnt receptor signalling pathway involved in animal/vegetal axis specification" EXACT [GOC:mah] synonym: "Wnt- activated signaling pathway involved in animal/vegetal axis specification" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0060832 ! oocyte animal/vegetal axis specification created_by: dph creation_date: 2009-08-11T03:20:39Z [Term] id: GO:0060834 name: oral/aboral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "oral/aboral axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification created_by: dph creation_date: 2009-08-11T03:25:26Z [Term] id: GO:0060835 name: transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0060834 ! oral/aboral axis specification relationship: part_of GO:0060834 ! oral/aboral axis specification created_by: dph creation_date: 2009-08-11T03:30:40Z [Term] id: GO:0060836 name: lymphatic endothelial cell differentiation namespace: biological_process def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation relationship: part_of GO:0001945 ! lymph vessel development created_by: dph creation_date: 2009-08-11T03:45:20Z [Term] id: GO:0060837 name: blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation relationship: part_of GO:0001568 ! blood vessel development created_by: dph creation_date: 2009-08-11T03:47:36Z [Term] id: GO:0060838 name: lymphatic endothelial cell fate commitment namespace: biological_process def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060839 ! endothelial cell fate commitment relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation created_by: dph creation_date: 2009-08-11T03:51:45Z [Term] id: GO:0060839 name: endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0045446 ! endothelial cell differentiation created_by: dph creation_date: 2009-08-11T03:52:53Z [Term] id: GO:0060840 name: artery development namespace: biological_process def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development created_by: dph creation_date: 2009-08-12T10:10:51Z [Term] id: GO:0060841 name: venous blood vessel development namespace: biological_process def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development created_by: dph creation_date: 2009-08-12T10:14:07Z [Term] id: GO:0060842 name: arterial endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation created_by: dph creation_date: 2009-08-12T10:41:34Z [Term] id: GO:0060843 name: venous endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation created_by: dph creation_date: 2009-08-12T10:43:40Z [Term] id: GO:0060844 name: arterial endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060846 ! blood vessel endothelial cell fate commitment relationship: part_of GO:0060842 ! arterial endothelial cell differentiation created_by: dph creation_date: 2009-08-12T10:49:00Z [Term] id: GO:0060845 name: venous endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060846 ! blood vessel endothelial cell fate commitment relationship: part_of GO:0060843 ! venous endothelial cell differentiation created_by: dph creation_date: 2009-08-12T10:51:23Z [Term] id: GO:0060846 name: blood vessel endothelial cell fate commitment namespace: biological_process def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060839 ! endothelial cell fate commitment relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation created_by: dph creation_date: 2009-08-12T10:56:14Z [Term] id: GO:0060847 name: endothelial cell fate specification namespace: biological_process def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0060839 ! endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:00:04Z [Term] id: GO:0060848 name: endothelial cell fate determination namespace: biological_process def: "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0060839 ! endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:11:14Z [Term] id: GO:0060849 name: regulation of transcription involved in lymphatic endothelial cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0060838 ! lymphatic endothelial cell fate commitment relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:19:14Z [Term] id: GO:0060850 name: regulation of transcription involved in cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0045165 ! cell fate commitment relationship: part_of GO:0045165 ! cell fate commitment created_by: dph creation_date: 2009-08-12T11:40:09Z [Term] id: GO:0060851 name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment" EXACT [GOC:mah] is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway intersection_of: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway intersection_of: part_of GO:0060838 ! lymphatic endothelial cell fate commitment relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:45:19Z [Term] id: GO:0060852 name: regulation of transcription involved in venous endothelial cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0060845 ! venous endothelial cell fate commitment relationship: part_of GO:0060845 ! venous endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:49:49Z [Term] id: GO:0060853 name: Notch signaling pathway involved in arterial endothelial cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Notch signalling pathway involved in arterial endothelial cell fate commitment" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0060844 ! arterial endothelial cell fate commitment relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment created_by: dph creation_date: 2009-08-12T11:54:49Z [Term] id: GO:0060854 name: branching involved in lymph vessel morphogenesis namespace: biological_process def: "The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "patterning of lymph vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: part_of GO:0036303 ! lymph vessel morphogenesis relationship: part_of GO:0001946 ! lymphangiogenesis created_by: dph creation_date: 2009-08-12T12:00:48Z [Term] id: GO:0060855 name: venous endothelial cell migration involved in lymph vessel development namespace: biological_process def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0001945 ! lymph vessel development created_by: dph creation_date: 2009-08-12T12:07:27Z [Term] id: GO:0060856 name: establishment of blood-brain barrier namespace: biological_process def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] synonym: "establishment of BBB" EXACT [PMID:20080302] is_a: GO:0048468 ! cell development created_by: dph creation_date: 2009-08-12T12:12:59Z [Term] id: GO:0060857 name: establishment of glial blood-brain barrier namespace: biological_process def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart] synonym: "establishment of glial BBB" EXACT [PMID:20080302] is_a: GO:0021782 ! glial cell development is_a: GO:0060856 ! establishment of blood-brain barrier created_by: dph creation_date: 2009-08-12T12:17:51Z [Term] id: GO:0060858 name: vesicle-mediated transport involved in floral organ abscission namespace: biological_process def: "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0022414 ! reproductive process intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: part_of GO:0010227 ! floral organ abscission relationship: part_of GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T03:48:54Z [Term] id: GO:0060859 name: regulation of vesicle-mediated transport involved in floral organ abscission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:0060860 ! regulation of floral organ abscission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission relationship: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission created_by: dph creation_date: 2009-08-12T03:56:21Z [Term] id: GO:0060860 name: regulation of floral organ abscission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009909 ! regulation of flower development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010227 ! floral organ abscission relationship: regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T03:59:45Z [Term] id: GO:0060861 name: positive regulation of floral organ abscission namespace: biological_process def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009911 ! positive regulation of flower development is_a: GO:0060860 ! regulation of floral organ abscission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010227 ! floral organ abscission relationship: positively_regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T04:03:09Z [Term] id: GO:0060862 name: negative regulation of floral organ abscission namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009910 ! negative regulation of flower development is_a: GO:0060860 ! regulation of floral organ abscission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010227 ! floral organ abscission relationship: negatively_regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T04:05:23Z [Term] id: GO:0060863 name: regulation of floral organ abscission by signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007165 ! signal transduction is_a: GO:0060860 ! regulation of floral organ abscission intersection_of: GO:0007165 ! signal transduction intersection_of: regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T04:07:41Z [Term] id: GO:0060864 name: positive regulation of floral organ abscission by small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007264 ! small GTPase mediated signal transduction is_a: GO:0060861 ! positive regulation of floral organ abscission is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction intersection_of: GO:0007264 ! small GTPase mediated signal transduction intersection_of: positively_regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T04:34:56Z [Term] id: GO:0060865 name: negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0060862 ! negative regulation of floral organ abscission is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: negatively_regulates GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T04:42:14Z [Term] id: GO:0060866 name: leaf abscission namespace: biological_process def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009838 ! abscission created_by: dph creation_date: 2009-08-12T06:33:55Z [Term] id: GO:0060867 name: fruit abscission namespace: biological_process def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009838 ! abscission created_by: dph creation_date: 2009-08-12T06:35:28Z [Term] id: GO:0060868 name: regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007264 ! small GTPase mediated signal transduction is_a: GO:0060859 ! regulation of vesicle-mediated transport involved in floral organ abscission is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction intersection_of: GO:0007264 ! small GTPase mediated signal transduction intersection_of: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission created_by: dph creation_date: 2009-08-12T06:52:13Z [Term] id: GO:0060869 name: transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:signaling, GOC:tb] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission" EXACT [GOC:mah] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0022414 ! reproductive process intersection_of: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: part_of GO:0010227 ! floral organ abscission relationship: part_of GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T07:02:07Z [Term] id: GO:0060870 name: cell wall disassembly involved in floral organ abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009830 ! cell wall modification involved in abscission is_a: GO:0022414 ! reproductive process intersection_of: GO:0044277 ! cell wall disassembly intersection_of: part_of GO:0010227 ! floral organ abscission relationship: part_of GO:0010227 ! floral organ abscission created_by: dph creation_date: 2009-08-12T07:15:36Z [Term] id: GO:0060872 name: semicircular canal development namespace: biological_process def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0035295 ! tube development relationship: part_of GO:0048839 ! inner ear development created_by: dph creation_date: 2009-08-13T09:36:37Z [Term] id: GO:0060873 name: anterior semicircular canal development namespace: biological_process def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development created_by: dph creation_date: 2009-08-13T09:39:49Z [Term] id: GO:0060874 name: posterior semicircular canal development namespace: biological_process def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development created_by: dph creation_date: 2009-08-13T09:42:39Z [Term] id: GO:0060875 name: lateral semicircular canal development namespace: biological_process def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060872 ! semicircular canal development created_by: dph creation_date: 2009-08-13T09:43:25Z [Term] id: GO:0060876 name: semicircular canal formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0035148 ! tube formation relationship: part_of GO:0048752 ! semicircular canal morphogenesis created_by: dph creation_date: 2009-08-13T09:45:07Z [Term] id: GO:0060877 name: regionalization involved in semicircular canal formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization intersection_of: GO:0003002 ! regionalization intersection_of: part_of GO:0060876 ! semicircular canal formation relationship: part_of GO:0060876 ! semicircular canal formation created_by: dph creation_date: 2009-08-13T09:56:45Z [Term] id: GO:0060878 name: pouch outgrowth involved in semicircular canal formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: part_of GO:0060876 ! semicircular canal formation relationship: part_of GO:0060876 ! semicircular canal formation created_by: dph creation_date: 2009-08-13T10:01:01Z [Term] id: GO:0060879 name: semicircular canal fusion namespace: biological_process def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060606 ! tube closure relationship: part_of GO:0060876 ! semicircular canal formation created_by: dph creation_date: 2009-08-13T10:05:51Z [Term] id: GO:0060880 name: cell morphogenesis involved in semicircular canal fusion namespace: biological_process def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0060879 ! semicircular canal fusion relationship: part_of GO:0060879 ! semicircular canal fusion created_by: dph creation_date: 2009-08-13T10:13:25Z [Term] id: GO:0060882 name: basement membrane disassembly involved in semicircular canal fusion namespace: biological_process def: "A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "basal lamina disassembly involved in semicircular canal fusion" RELATED [] is_a: GO:0034769 ! basement membrane disassembly intersection_of: GO:0034769 ! basement membrane disassembly intersection_of: part_of GO:0060879 ! semicircular canal fusion relationship: part_of GO:0060879 ! semicircular canal fusion created_by: dph creation_date: 2009-08-13T11:29:52Z [Term] id: GO:0060883 name: regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication" RELATED [] is_a: GO:0007154 ! cell communication is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0110011 ! regulation of basement membrane organization is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: regulates GO:0060882 ! basement membrane disassembly involved in semicircular canal fusion created_by: dph creation_date: 2009-08-13T11:31:56Z [Term] id: GO:0060884 name: clearance of cells from fusion plate namespace: biological_process def: "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048752 ! semicircular canal morphogenesis created_by: dph creation_date: 2009-08-13T12:25:59Z [Term] id: GO:0060885 name: clearance of cells from fusion plate by apoptotic process namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:mtg_apoptosis, GOC:sdb_2009, GOC:tb] synonym: "clearance of cells from fusion plate by apoptosis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis is_a: GO:0060884 ! clearance of cells from fusion plate created_by: dph creation_date: 2009-08-13T12:30:17Z [Term] id: GO:0060886 name: clearance of cells from fusion plate by epithelial to mesenchymal transition namespace: biological_process def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0060884 ! clearance of cells from fusion plate created_by: dph creation_date: 2009-08-13T12:34:19Z [Term] id: GO:0060887 name: limb epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0098773 ! skin epidermis development relationship: part_of GO:0060173 ! limb development created_by: dph creation_date: 2009-08-13T12:39:39Z [Term] id: GO:0060888 name: limb epidermis stratification namespace: biological_process def: "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060887 ! limb epidermis development created_by: dph creation_date: 2009-08-13T12:45:48Z [Term] id: GO:0060889 name: limb basal epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0060887 ! limb epidermis development created_by: dph creation_date: 2009-08-13T01:22:12Z [Term] id: GO:0060890 name: limb spinous cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0030216 ! keratinocyte differentiation relationship: part_of GO:0060887 ! limb epidermis development created_by: dph creation_date: 2009-08-13T01:31:30Z [Term] id: GO:0060891 name: limb granular cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0030216 ! keratinocyte differentiation relationship: part_of GO:0060887 ! limb epidermis development created_by: dph creation_date: 2009-08-13T01:33:14Z [Term] id: GO:0060892 name: limb basal epidermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation created_by: dph creation_date: 2009-08-13T01:41:47Z [Term] id: GO:0060893 name: limb granular cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060891 ! limb granular cell differentiation created_by: dph creation_date: 2009-08-13T01:44:14Z [Term] id: GO:0060894 name: limb spinous cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0060888 ! limb epidermis stratification relationship: part_of GO:0060890 ! limb spinous cell differentiation created_by: dph creation_date: 2009-08-13T01:46:23Z [Term] id: GO:0060895 name: retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0021513 ! spinal cord dorsal/ventral patterning relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning created_by: dph creation_date: 2009-08-13T01:51:50Z [Term] id: GO:0060896 name: neural plate pattern specification namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0007389 ! pattern specification process created_by: dph creation_date: 2009-08-13T02:06:27Z [Term] id: GO:0060897 name: neural plate regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060896 ! neural plate pattern specification created_by: dph creation_date: 2009-08-13T02:09:04Z [Term] id: GO:0060898 name: eye field cell fate commitment involved in camera-type eye formation namespace: biological_process def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060581 ! cell fate commitment involved in pattern specification relationship: part_of GO:0046619 ! optic placode formation involved in camera-type eye formation relationship: part_of GO:0060897 ! neural plate regionalization created_by: dph creation_date: 2009-08-13T02:10:58Z [Term] id: GO:0060899 name: obsolete regulation of transcription involved in eye field cell fate commitment of camera-type eye namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2009-08-13T02:11:48Z [Term] id: GO:0060900 name: embryonic camera-type eye formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis created_by: dph creation_date: 2009-08-13T02:26:54Z [Term] id: GO:0060901 name: regulation of hair cycle by canonical Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of hair cycle by canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of hair cycle by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of hair cycle by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0042634 ! regulation of hair cycle is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: regulates GO:0042633 ! hair cycle created_by: dph creation_date: 2009-08-13T02:41:10Z [Term] id: GO:0060902 name: regulation of hair cycle by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of hair cycle by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0042634 ! regulation of hair cycle intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: regulates GO:0042633 ! hair cycle created_by: dph creation_date: 2009-08-13T02:45:12Z [Term] id: GO:0060903 name: positive regulation of meiosis I namespace: biological_process def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] is_a: GO:0045836 ! positive regulation of meiotic nuclear division is_a: GO:0060631 ! regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007127 ! meiosis I relationship: positively_regulates GO:0007127 ! meiosis I created_by: dph creation_date: 2009-08-14T01:06:57Z [Term] id: GO:0060904 name: regulation of protein folding in endoplasmic reticulum namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb] is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034975 ! protein folding in endoplasmic reticulum relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum created_by: dph creation_date: 2009-08-14T01:12:00Z [Term] id: GO:0060905 name: regulation of induction of conjugation upon nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation created_by: dph creation_date: 2009-08-14T01:17:50Z [Term] id: GO:0060906 name: negative regulation of chromatin silencing by small RNA namespace: biological_process def: "Any process that decreases the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb] is_a: GO:0010964 ! regulation of chromatin silencing by small RNA is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0060967 ! negative regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031048 ! chromatin silencing by small RNA relationship: negatively_regulates GO:0031048 ! chromatin silencing by small RNA created_by: dph creation_date: 2009-08-14T01:22:24Z [Term] id: GO:0060907 name: positive regulation of macrophage cytokine production namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb] is_a: GO:0010935 ! regulation of macrophage cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010934 ! macrophage cytokine production relationship: positively_regulates GO:0010934 ! macrophage cytokine production created_by: dph creation_date: 2009-09-04T02:32:18Z [Term] id: GO:0060908 name: plasmid copy number maintenance namespace: biological_process def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb] is_a: GO:0006276 ! plasmid maintenance created_by: dph creation_date: 2009-09-04T02:49:08Z [Term] id: GO:0060909 name: regulation of DNA replication initiation involved in plasmid copy number maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation relationship: part_of GO:0060908 ! plasmid copy number maintenance created_by: dph creation_date: 2009-09-04T02:51:48Z [Term] id: GO:0060910 name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance namespace: biological_process def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance created_by: dph creation_date: 2009-09-04T02:56:29Z [Term] id: GO:0060911 name: cardiac cell fate commitment namespace: biological_process def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart] synonym: "cardiocyte cell fate commitment" EXACT [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0035051 ! cardiocyte differentiation created_by: dph creation_date: 2009-09-17T08:47:00Z [Term] id: GO:0060912 name: cardiac cell fate specification namespace: biological_process def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart] synonym: "cardiocyte cell fate specification" EXACT [GOC:dph] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0060911 ! cardiac cell fate commitment created_by: dph creation_date: 2009-09-17T08:53:21Z [Term] id: GO:0060913 name: cardiac cell fate determination namespace: biological_process def: "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart] synonym: "cardiocyte cell fate determination" RELATED [GOC:dph] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0060911 ! cardiac cell fate commitment created_by: dph creation_date: 2009-09-17T08:55:29Z [Term] id: GO:0060914 name: heart formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "cardiogenesis" RELATED [GOC:mtg_heart] is_a: GO:0048645 ! animal organ formation relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-09-17T09:02:13Z [Term] id: GO:0060915 name: mesenchymal cell differentiation involved in lung development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0030324 ! lung development relationship: part_of GO:0030324 ! lung development created_by: dph creation_date: 2009-09-18T11:45:33Z [Term] id: GO:0060916 name: mesenchymal cell proliferation involved in lung development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: part_of GO:0030324 ! lung development relationship: part_of GO:0030324 ! lung development created_by: dph creation_date: 2009-09-18T11:50:17Z [Term] id: GO:0060917 name: regulation of (1->6)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:dph, GOC:tb] synonym: "regulation of 1,6-beta-glucan biosynthetic process" EXACT [] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process relationship: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process created_by: dph creation_date: 2009-09-18T02:15:01Z [Term] id: GO:0060918 name: auxin transport namespace: biological_process def: "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0009914 ! hormone transport created_by: dph creation_date: 2009-09-28T02:44:54Z [Term] id: GO:0060919 name: auxin influx namespace: biological_process def: "The process involved in the transport of auxin into the cell." [GOC:dph, GOC:tb] is_a: GO:0060918 ! auxin transport created_by: dph creation_date: 2009-09-28T02:49:18Z [Term] id: GO:0060920 name: cardiac pacemaker cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell differentiation" BROAD [] is_a: GO:0055007 ! cardiac muscle cell differentiation created_by: dph creation_date: 2009-09-29T11:01:31Z [Term] id: GO:0060921 name: sinoatrial node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060920 ! cardiac pacemaker cell differentiation relationship: part_of GO:0003163 ! sinoatrial node development created_by: dph creation_date: 2009-09-29T11:03:30Z [Term] id: GO:0060922 name: atrioventricular node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] is_a: GO:0003292 ! cardiac septum cell differentiation is_a: GO:0060920 ! cardiac pacemaker cell differentiation relationship: part_of GO:0003162 ! atrioventricular node development created_by: dph creation_date: 2009-09-29T11:07:06Z [Term] id: GO:0060923 name: cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0042693 ! muscle cell fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0055007 ! cardiac muscle cell differentiation created_by: dph creation_date: 2009-09-29T11:13:32Z [Term] id: GO:0060924 name: atrial cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart] synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation created_by: dph creation_date: 2009-09-29T11:46:10Z [Term] id: GO:0060925 name: ventricular cardiac muscle cell fate commitment namespace: biological_process def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation created_by: dph creation_date: 2009-09-29T11:49:39Z [Term] id: GO:0060926 name: cardiac pacemaker cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell development" BROAD [] is_a: GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation created_by: dph creation_date: 2009-09-29T11:51:55Z [Term] id: GO:0060927 name: cardiac pacemaker cell fate commitment namespace: biological_process def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell fate commitment" BROAD [] is_a: GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation created_by: dph creation_date: 2009-09-29T11:54:22Z [Term] id: GO:0060928 name: atrioventricular node cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "AV node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! cardiac pacemaker cell development relationship: part_of GO:0060922 ! atrioventricular node cell differentiation created_by: dph creation_date: 2009-09-29T11:59:26Z [Term] id: GO:0060929 name: atrioventricular node cell fate commitment namespace: biological_process def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart] synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060927 ! cardiac pacemaker cell fate commitment relationship: part_of GO:0060922 ! atrioventricular node cell differentiation created_by: dph creation_date: 2009-09-29T12:01:24Z [Term] id: GO:0060930 name: sinoatrial node cell fate commitment namespace: biological_process def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell commitment" EXACT [GOC:mtg_heart] synonym: "SAN cell commitment" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell commitment" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060927 ! cardiac pacemaker cell fate commitment relationship: part_of GO:0060921 ! sinoatrial node cell differentiation created_by: dph creation_date: 2009-09-29T12:03:38Z [Term] id: GO:0060931 name: sinoatrial node cell development namespace: biological_process def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell development" EXACT [GOC:mtg_heart] synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060926 ! cardiac pacemaker cell development relationship: part_of GO:0060921 ! sinoatrial node cell differentiation created_by: dph creation_date: 2009-09-29T12:05:47Z [Term] id: GO:0060932 name: His-Purkinje system cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation relationship: part_of GO:0003164 ! His-Purkinje system development created_by: dph creation_date: 2009-09-29T01:10:32Z [Term] id: GO:0060933 name: His-Purkinje system cell development namespace: biological_process def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation created_by: dph creation_date: 2009-09-29T01:15:02Z [Term] id: GO:0060934 name: His-Purkinje system cell fate commitment namespace: biological_process def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation created_by: dph creation_date: 2009-09-29T01:17:00Z [Term] id: GO:0060935 name: cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation created_by: dph creation_date: 2009-09-29T01:20:04Z [Term] id: GO:0060936 name: cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:23:03Z [Term] id: GO:0060937 name: cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:24:59Z [Term] id: GO:0060938 name: epicardium-derived cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060935 ! cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:28:03Z [Term] id: GO:0060939 name: epicardium-derived cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060936 ! cardiac fibroblast cell development relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:29:19Z [Term] id: GO:0060940 name: epithelial to mesenchymal transition involved in cardiac fibroblast development namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: GO:0060317 ! cardiac epithelial to mesenchymal transition intersection_of: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development created_by: dph creation_date: 2009-09-29T01:32:36Z [Term] id: GO:0060941 name: epicardium-derived cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060937 ! cardiac fibroblast cell fate commitment relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:44:36Z [Term] id: GO:0060942 name: neural crest-derived cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060935 ! cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T01:54:19Z [Term] id: GO:0060943 name: neural crest-derived cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060936 ! cardiac fibroblast cell development relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T02:31:24Z [Term] id: GO:0060944 name: neural crest-derived cardiac fibroblast cell fate commitment namespace: biological_process def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0060937 ! cardiac fibroblast cell fate commitment relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation created_by: dph creation_date: 2009-09-29T02:42:39Z [Term] id: GO:0060945 name: cardiac neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] is_a: GO:0030182 ! neuron differentiation is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0048483 ! autonomic nervous system development created_by: dph creation_date: 2009-09-29T02:45:33Z [Term] id: GO:0060946 name: cardiac blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0060837 ! blood vessel endothelial cell differentiation created_by: dph creation_date: 2009-09-29T02:48:55Z [Term] id: GO:0060947 name: cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0035886 ! vascular smooth muscle cell differentiation relationship: part_of GO:0060976 ! coronary vasculature development created_by: dph creation_date: 2009-09-29T02:56:08Z [Term] id: GO:0060948 name: cardiac vascular smooth muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development is_a: GO:0097084 ! vascular smooth muscle cell development relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-09-29T03:00:24Z [Term] id: GO:0060949 name: cardiac vascular smooth muscle cell fate commitment namespace: biological_process def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment is_a: GO:0097081 ! vascular smooth muscle cell fate commitment relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-09-29T03:02:45Z [Term] id: GO:0060950 name: cardiac glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0035051 ! cardiocyte differentiation created_by: dph creation_date: 2009-09-29T03:06:37Z [Term] id: GO:0060951 name: neural crest-derived cardiac glial cell differentiation namespace: biological_process def: "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0060950 ! cardiac glial cell differentiation created_by: dph creation_date: 2009-09-29T03:08:06Z [Term] id: GO:0060952 name: cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] is_a: GO:0021782 ! glial cell development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060950 ! cardiac glial cell differentiation created_by: dph creation_date: 2009-09-29T03:09:24Z [Term] id: GO:0060953 name: cardiac glial cell fate commitment namespace: biological_process def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060950 ! cardiac glial cell differentiation created_by: dph creation_date: 2009-09-29T03:11:23Z [Term] id: GO:0060954 name: neural crest-derived cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart] is_a: GO:0060952 ! cardiac glial cell development relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation created_by: dph creation_date: 2009-09-29T03:14:15Z [Term] id: GO:0060955 name: neural crest-derived cardiac glial cell fate commitment namespace: biological_process def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] is_a: GO:0060953 ! cardiac glial cell fate commitment relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation created_by: dph creation_date: 2009-09-29T03:15:04Z [Term] id: GO:0060956 name: endocardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2009-09-29T03:20:39Z [Term] id: GO:0060957 name: endocardial cell fate commitment namespace: biological_process def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0060839 ! endothelial cell fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060956 ! endocardial cell differentiation created_by: dph creation_date: 2009-09-29T03:24:29Z [Term] id: GO:0060958 name: endocardial cell development namespace: biological_process def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0001885 ! endothelial cell development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060956 ! endocardial cell differentiation created_by: dph creation_date: 2009-09-29T03:26:59Z [Term] id: GO:0060959 name: cardiac neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart neuron development" EXACT [GOC:mtg_heart] is_a: GO:0048666 ! neuron development is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0060945 ! cardiac neuron differentiation created_by: dph creation_date: 2009-09-30T10:14:56Z [Term] id: GO:0060960 name: cardiac neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0048663 ! neuron fate commitment is_a: GO:0060911 ! cardiac cell fate commitment relationship: part_of GO:0060945 ! cardiac neuron differentiation created_by: dph creation_date: 2009-09-30T10:23:47Z [Term] id: GO:0060961 name: phospholipase D inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [GOC:dph, GOC:tb] is_a: GO:0004859 ! phospholipase inhibitor activity relationship: negatively_regulates GO:0004630 ! phospholipase D activity created_by: dph creation_date: 2009-10-05T02:47:26Z [Term] id: GO:0060962 name: regulation of ribosomal protein gene transcription by RNA polymerase II namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II created_by: dph creation_date: 2009-10-05T03:00:40Z [Term] id: GO:0060963 name: positive regulation of ribosomal protein gene transcription by RNA polymerase II namespace: biological_process def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II created_by: dph creation_date: 2009-10-05T03:04:05Z [Term] id: GO:0060964 name: regulation of gene silencing by miRNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604] synonym: "regulation of gene silencing by microRNA" EXACT [GOC:pr] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035195 ! gene silencing by miRNA relationship: regulates GO:0035195 ! gene silencing by miRNA created_by: dph creation_date: 2009-10-05T03:10:28Z [Term] id: GO:0060965 name: negative regulation of gene silencing by miRNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing by miRNA." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604] synonym: "negative regulation of gene silencing by microRNA" EXACT [GOC:bf, GOC:pr] is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing is_a: GO:0060964 ! regulation of gene silencing by miRNA is_a: GO:0060967 ! negative regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035195 ! gene silencing by miRNA relationship: negatively_regulates GO:0035195 ! gene silencing by miRNA created_by: dph creation_date: 2009-10-05T03:14:14Z [Term] id: GO:0060966 name: regulation of gene silencing by RNA namespace: biological_process def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031047 ! gene silencing by RNA relationship: regulates GO:0031047 ! gene silencing by RNA created_by: dph creation_date: 2009-10-05T03:17:02Z [Term] id: GO:0060967 name: negative regulation of gene silencing by RNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] is_a: GO:0060966 ! regulation of gene silencing by RNA is_a: GO:0060969 ! negative regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031047 ! gene silencing by RNA relationship: negatively_regulates GO:0031047 ! gene silencing by RNA created_by: dph creation_date: 2009-10-05T03:21:05Z [Term] id: GO:0060968 name: regulation of gene silencing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016458 ! gene silencing relationship: regulates GO:0016458 ! gene silencing created_by: dph creation_date: 2009-10-05T03:23:56Z [Term] id: GO:0060969 name: negative regulation of gene silencing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016458 ! gene silencing relationship: negatively_regulates GO:0016458 ! gene silencing created_by: dph creation_date: 2009-10-05T03:26:19Z [Term] id: GO:0060970 name: embryonic heart tube dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0035050 ! embryonic heart tube development created_by: dph creation_date: 2009-10-06T10:14:53Z [Term] id: GO:0060971 name: embryonic heart tube left/right pattern formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart] is_a: GO:0060972 ! left/right pattern formation relationship: part_of GO:0035050 ! embryonic heart tube development created_by: dph creation_date: 2009-10-06T10:22:11Z [Term] id: GO:0060972 name: left/right pattern formation namespace: biological_process def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart] is_a: GO:0003002 ! regionalization created_by: dph creation_date: 2009-10-06T10:25:58Z [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-06T10:53:49Z [Term] id: GO:0060974 name: cell migration involved in heart formation namespace: biological_process def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060914 ! heart formation relationship: part_of GO:0060914 ! heart formation created_by: dph creation_date: 2009-10-06T10:56:33Z [Term] id: GO:0060975 name: cardioblast migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart] synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0060029 ! convergent extension involved in organogenesis created_by: dph creation_date: 2009-10-06T10:59:36Z [Term] id: GO:0060976 name: coronary vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart vasculature development" EXACT [GOC:mtg_heart] is_a: GO:0001568 ! blood vessel development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-06T12:15:23Z [Term] id: GO:0060977 name: coronary vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0060976 ! coronary vasculature development created_by: dph creation_date: 2009-10-06T12:28:23Z [Term] id: GO:0060978 name: angiogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: part_of GO:0060976 ! coronary vasculature development relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-06T02:02:12Z [Term] id: GO:0060979 name: vasculogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-06T02:19:42Z [Term] id: GO:0060980 name: cell migration involved in coronary vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] is_a: GO:0035441 ! cell migration involved in vasculogenesis is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis created_by: dph creation_date: 2009-10-06T02:33:06Z [Term] id: GO:0060981 name: cell migration involved in coronary angiogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis created_by: dph creation_date: 2009-10-06T02:49:12Z [Term] id: GO:0060982 name: coronary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart] is_a: GO:0048844 ! artery morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-06T02:58:52Z [Term] id: GO:0060983 name: epicardium-derived cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-10-06T03:05:33Z [Term] id: GO:0060984 name: epicardium-derived cardiac vascular smooth muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart] is_a: GO:0060948 ! cardiac vascular smooth muscle cell development relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-10-06T03:07:09Z [Term] id: GO:0060985 name: epicardium-derived cardiac vascular smooth muscle cell fate commitment namespace: biological_process def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-10-06T03:11:11Z [Term] id: GO:0060986 name: endocrine hormone secretion namespace: biological_process def: "The regulated release of a hormone into the circulatory system." [GOC:dph] is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0050886 ! endocrine process created_by: dph creation_date: 2010-01-11T09:03:48Z [Term] id: GO:0060987 name: lipid tube namespace: cellular_component def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032994 ! protein-lipid complex created_by: dph creation_date: 2010-01-11T01:54:25Z [Term] id: GO:0060988 name: lipid tube assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0065005 ! protein-lipid complex assembly created_by: dph creation_date: 2010-01-11T01:56:59Z [Term] id: GO:0060989 name: lipid tube assembly involved in organelle fusion namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060988 ! lipid tube assembly intersection_of: GO:0060988 ! lipid tube assembly intersection_of: part_of GO:0048284 ! organelle fusion relationship: part_of GO:0048284 ! organelle fusion created_by: dph creation_date: 2010-01-11T02:06:50Z [Term] id: GO:0060990 name: lipid tube assembly involved in organelle fission namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060988 ! lipid tube assembly intersection_of: GO:0060988 ! lipid tube assembly intersection_of: part_of GO:0048285 ! organelle fission relationship: part_of GO:0048285 ! organelle fission created_by: dph creation_date: 2010-01-11T02:14:48Z [Term] id: GO:0060991 name: obsolete lipid tube assembly involved in cytokinesis namespace: biological_process def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: This term was made obsolete because there is no evidence the process exists. synonym: "lipid tube assembly involved in cytokinesis" EXACT [] synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_obsolete: true created_by: dph creation_date: 2010-01-11T02:22:25Z [Term] id: GO:0060992 name: response to fungicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph] is_a: GO:0009636 ! response to toxic substance is_a: GO:0046677 ! response to antibiotic created_by: dph creation_date: 2010-01-13T08:05:58Z [Term] id: GO:0060993 name: kidney morphogenesis namespace: biological_process def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2010-01-19T08:16:55Z [Term] id: GO:0060994 name: regulation of transcription from RNA polymerase II promoter involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2010-01-19T08:24:46Z [Term] id: GO:0060995 name: cell-cell signaling involved in kidney development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2010-01-19T08:33:40Z [Term] id: GO:0060996 name: dendritic spine development namespace: biological_process def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0016358 ! dendrite development created_by: dph creation_date: 2010-01-20T09:06:33Z [Term] id: GO:0060997 name: dendritic spine morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0031175 ! neuron projection development is_a: GO:0048812 ! neuron projection morphogenesis is_a: GO:0097061 ! dendritic spine organization relationship: part_of GO:0048813 ! dendrite morphogenesis relationship: part_of GO:0060996 ! dendritic spine development created_by: dph creation_date: 2010-01-20T09:09:57Z [Term] id: GO:0060998 name: regulation of dendritic spine development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060996 ! dendritic spine development relationship: regulates GO:0060996 ! dendritic spine development created_by: dph creation_date: 2010-01-20T09:17:06Z [Term] id: GO:0060999 name: positive regulation of dendritic spine development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0060998 ! regulation of dendritic spine development is_a: GO:1900006 ! positive regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060996 ! dendritic spine development relationship: positively_regulates GO:0060996 ! dendritic spine development created_by: dph creation_date: 2010-01-20T09:27:21Z [Term] id: GO:0061000 name: negative regulation of dendritic spine development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0060998 ! regulation of dendritic spine development is_a: GO:2000171 ! negative regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060996 ! dendritic spine development relationship: negatively_regulates GO:0060996 ! dendritic spine development created_by: dph creation_date: 2010-01-20T09:29:18Z [Term] id: GO:0061001 name: regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0060998 ! regulation of dendritic spine development is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060997 ! dendritic spine morphogenesis relationship: regulates GO:0060997 ! dendritic spine morphogenesis created_by: dph creation_date: 2010-01-20T09:31:52Z [Term] id: GO:0061002 name: negative regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0050774 ! negative regulation of dendrite morphogenesis is_a: GO:0061000 ! negative regulation of dendritic spine development is_a: GO:0061001 ! regulation of dendritic spine morphogenesis is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060997 ! dendritic spine morphogenesis relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis created_by: dph creation_date: 2010-01-20T09:34:49Z [Term] id: GO:0061003 name: positive regulation of dendritic spine morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] is_a: GO:0050775 ! positive regulation of dendrite morphogenesis is_a: GO:0060999 ! positive regulation of dendritic spine development is_a: GO:0061001 ! regulation of dendritic spine morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060997 ! dendritic spine morphogenesis relationship: positively_regulates GO:0060997 ! dendritic spine morphogenesis created_by: dph creation_date: 2010-01-20T09:36:54Z [Term] id: GO:0061004 name: pattern specification involved in kidney development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0007389 ! pattern specification process intersection_of: GO:0007389 ! pattern specification process intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development relationship: part_of GO:0072048 ! renal system pattern specification created_by: dph creation_date: 2010-01-21T09:05:54Z [Term] id: GO:0061005 name: cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2010-01-21T09:13:55Z [Term] id: GO:0061006 name: regulation of cell proliferation involved in kidney morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: part_of GO:0060993 ! kidney morphogenesis relationship: part_of GO:0060993 ! kidney morphogenesis created_by: dph creation_date: 2010-01-21T11:25:23Z [Term] id: GO:0061007 name: hepaticobiliary system process namespace: biological_process def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system process" EXACT [GOC:dph] is_a: GO:0003008 ! system process created_by: dph creation_date: 2010-01-22T09:09:10Z [Term] id: GO:0061008 name: hepaticobiliary system development namespace: biological_process def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system development" EXACT [GOC:dph] is_a: GO:0048731 ! system development created_by: dph creation_date: 2010-01-22T09:11:59Z [Term] id: GO:0061009 name: common bile duct development namespace: biological_process def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine." [PMID:20614624] synonym: "bile duct development" EXACT [GOC:dph] synonym: "CBD development" EXACT [PMID:20614624] synonym: "EHBD development" BROAD [PMID:20614624] synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] is_a: GO:0035295 ! tube development relationship: part_of GO:0061008 ! hepaticobiliary system development created_by: dph creation_date: 2010-01-22T09:17:13Z [Term] id: GO:0061010 name: gall bladder development namespace: biological_process def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOC:dph] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0061008 ! hepaticobiliary system development created_by: dph creation_date: 2010-01-22T09:38:44Z [Term] id: GO:0061011 name: hepatic duct development namespace: biological_process def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] is_a: GO:0061009 ! common bile duct development created_by: dph creation_date: 2010-01-22T09:44:39Z [Term] id: GO:0061013 name: regulation of mRNA catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006402 ! mRNA catabolic process relationship: regulates GO:0006402 ! mRNA catabolic process created_by: dph creation_date: 2010-01-29T01:48:10Z [Term] id: GO:0061014 name: positive regulation of mRNA catabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0061013 ! regulation of mRNA catabolic process is_a: GO:1903313 ! positive regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006402 ! mRNA catabolic process relationship: positively_regulates GO:0006402 ! mRNA catabolic process created_by: dph creation_date: 2010-01-29T01:58:03Z [Term] id: GO:0061015 name: snRNA import into nucleus namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006404 ! RNA import into nucleus is_a: GO:0051030 ! snRNA transport created_by: dph creation_date: 2010-01-29T02:36:00Z [Term] id: GO:0061016 name: snRNA localization to Cajal body namespace: biological_process def: "The directed movement of snRNA, small nuclear ribonucleic acid, to a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090670 ! RNA localization to Cajal body created_by: dph creation_date: 2010-01-29T02:40:50Z [Term] id: GO:0061017 name: hepatoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0001889 ! liver development created_by: dph creation_date: 2010-02-02T09:08:03Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: janelomax creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process alt_id: GO:0006944 alt_id: GO:0044801 def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] synonym: "single-organism membrane fusion" RELATED [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization created_by: janelomax creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061026 name: cardiac muscle tissue regeneration namespace: biological_process def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] is_a: GO:0042246 ! tissue regeneration created_by: dph creation_date: 2010-02-09T08:25:51Z [Term] id: GO:0061027 name: umbilical cord development namespace: biological_process def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph] is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2010-02-09T09:09:22Z [Term] id: GO:0061028 name: establishment of endothelial barrier namespace: biological_process def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph] is_a: GO:0001885 ! endothelial cell development created_by: dph creation_date: 2010-02-09T09:26:59Z [Term] id: GO:0061029 name: eyelid development in camera-type eye namespace: biological_process def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development created_by: dph creation_date: 2010-02-09T09:36:11Z [Term] id: GO:0061030 name: epithelial cell differentiation involved in mammary gland alveolus development namespace: biological_process def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph, GOC:yaf] is_a: GO:0060644 ! mammary gland epithelial cell differentiation intersection_of: GO:0030855 ! epithelial cell differentiation intersection_of: part_of GO:0060749 ! mammary gland alveolus development relationship: part_of GO:0060749 ! mammary gland alveolus development created_by: dph creation_date: 2010-02-09T09:43:00Z [Term] id: GO:0061031 name: endodermal digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf] is_a: GO:0048546 ! digestive tract morphogenesis created_by: dph creation_date: 2010-02-09T09:46:43Z [Term] id: GO:0061032 name: visceral serous pericardium development namespace: biological_process def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf] synonym: "epicardium development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060039 ! pericardium development created_by: dph creation_date: 2010-02-09T09:52:49Z [Term] id: GO:0061033 name: secretion by lung epithelial cell involved in lung growth namespace: biological_process def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph] synonym: "fetal lung liquid secretion" RELATED [GOC:dph] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0060437 ! lung growth created_by: dph creation_date: 2010-02-09T10:02:55Z [Term] id: GO:0061034 name: olfactory bulb mitral cell layer development namespace: biological_process def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021772 ! olfactory bulb development created_by: dph creation_date: 2010-02-09T03:30:23Z [Term] id: GO:0061035 name: regulation of cartilage development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051216 ! cartilage development relationship: regulates GO:0051216 ! cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061036 name: positive regulation of cartilage development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051216 ! cartilage development relationship: positively_regulates GO:0051216 ! cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061037 name: negative regulation of cartilage development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051216 ! cartilage development relationship: negatively_regulates GO:0051216 ! cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061038 name: uterus morphogenesis namespace: biological_process def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0060065 ! uterus development created_by: dph creation_date: 2010-02-22T11:12:35Z [Term] id: GO:0061040 name: female gonad morphogenesis namespace: biological_process def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035262 ! gonad morphogenesis relationship: part_of GO:0008585 ! female gonad development created_by: dph creation_date: 2010-02-22T11:29:28Z [Term] id: GO:0061041 name: regulation of wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042060 ! wound healing relationship: regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:14:37Z [Term] id: GO:0061042 name: vascular wound healing namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0060055 ! angiogenesis involved in wound healing created_by: dph creation_date: 2010-02-25T10:18:26Z [Term] id: GO:0061043 name: regulation of vascular wound healing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0061041 ! regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061042 ! vascular wound healing relationship: regulates GO:0061042 ! vascular wound healing created_by: dph creation_date: 2010-02-25T10:21:59Z [Term] id: GO:0061044 name: negative regulation of vascular wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:0061043 ! regulation of vascular wound healing is_a: GO:0061045 ! negative regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061042 ! vascular wound healing relationship: negatively_regulates GO:0061042 ! vascular wound healing created_by: dph creation_date: 2010-02-25T10:24:28Z [Term] id: GO:0061045 name: negative regulation of wound healing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042060 ! wound healing relationship: negatively_regulates GO:0042060 ! wound healing created_by: dph creation_date: 2010-02-25T10:33:30Z [Term] id: GO:0061046 name: regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:41:38Z [Term] id: GO:0061047 name: positive regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:50:01Z [Term] id: GO:0061048 name: negative regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis created_by: dph creation_date: 2010-02-25T10:51:31Z [Term] id: GO:0061049 name: cell growth involved in cardiac muscle cell development namespace: biological_process def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] synonym: "cardiomyocyte growth" RELATED [GOC:dph] synonym: "heart muscle cell growth" RELATED [GOC:dph] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0016049 ! cell growth intersection_of: part_of GO:0055013 ! cardiac muscle cell development relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy relationship: part_of GO:0055013 ! cardiac muscle cell development created_by: dph creation_date: 2010-02-25T12:56:07Z [Term] id: GO:0061050 name: regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060284 ! regulation of cell development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:05:16Z [Term] id: GO:0061051 name: positive regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:08:08Z [Term] id: GO:0061052 name: negative regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development created_by: dph creation_date: 2010-02-25T01:11:30Z [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0009790 ! embryo development created_by: dph creation_date: 2010-03-02T12:05:13Z [Term] id: GO:0061054 name: dermatome development namespace: biological_process def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061053 ! somite development created_by: dph creation_date: 2010-03-02T12:07:37Z [Term] id: GO:0061055 name: myotome development namespace: biological_process def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061053 ! somite development created_by: dph creation_date: 2010-03-02T12:11:01Z [Term] id: GO:0061056 name: sclerotome development namespace: biological_process def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0061053 ! somite development created_by: dph creation_date: 2010-03-02T12:12:40Z [Term] id: GO:0061057 name: peptidoglycan recognition protein signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] synonym: "Imd signaling pathway" EXACT [GOC:dph] synonym: "Imd signalling pathway" EXACT [GOC:dph] synonym: "immune deficiency pathway" RELATED [GOC:dph] synonym: "immune deficiency signaling pathway" RELATED [GOC:dph] synonym: "PGRP signaling pathway" RELATED [GOC:dph] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0042742 ! defense response to bacterium created_by: dph creation_date: 2010-03-02T12:20:10Z [Term] id: GO:0061058 name: regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway relationship: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway created_by: dph creation_date: 2010-03-02T12:35:40Z [Term] id: GO:0061059 name: positive regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "positive regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway is_a: GO:1900426 ! positive regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway relationship: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway created_by: dph creation_date: 2010-03-02T12:37:44Z [Term] id: GO:0061060 name: negative regulation of peptidoglycan recognition protein signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] synonym: "negative regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway is_a: GO:1900425 ! negative regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway relationship: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway created_by: dph creation_date: 2010-03-02T12:38:42Z [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] subset: goslim_drosophila is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2010-03-09T08:55:14Z [Term] id: GO:0061062 name: regulation of nematode larval development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002119 ! nematode larval development relationship: regulates GO:0002119 ! nematode larval development created_by: dph creation_date: 2010-03-11T12:59:21Z [Term] id: GO:0061063 name: positive regulation of nematode larval development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002119 ! nematode larval development relationship: positively_regulates GO:0002119 ! nematode larval development created_by: dph creation_date: 2010-03-11T01:03:34Z [Term] id: GO:0061064 name: negative regulation of nematode larval development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002119 ! nematode larval development relationship: negatively_regulates GO:0002119 ! nematode larval development created_by: dph creation_date: 2010-03-11T01:04:39Z [Term] id: GO:0061065 name: regulation of dauer larval development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061062 ! regulation of nematode larval development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0040024 ! dauer larval development relationship: regulates GO:0040024 ! dauer larval development created_by: dph creation_date: 2010-03-11T01:07:07Z [Term] id: GO:0061066 name: positive regulation of dauer larval development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061063 ! positive regulation of nematode larval development is_a: GO:0061065 ! regulation of dauer larval development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0040024 ! dauer larval development relationship: positively_regulates GO:0040024 ! dauer larval development created_by: dph creation_date: 2010-03-11T01:09:11Z [Term] id: GO:0061067 name: negative regulation of dauer larval development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] is_a: GO:0061064 ! negative regulation of nematode larval development is_a: GO:0061065 ! regulation of dauer larval development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0040024 ! dauer larval development relationship: negatively_regulates GO:0040024 ! dauer larval development created_by: dph creation_date: 2010-03-11T01:10:23Z [Term] id: GO:0061068 name: urethra development namespace: biological_process def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development created_by: dph creation_date: 2010-03-12T08:24:52Z [Term] id: GO:0061069 name: male urethra development namespace: biological_process def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph] is_a: GO:0061068 ! urethra development created_by: dph creation_date: 2010-03-12T08:28:19Z [Term] id: GO:0061070 name: female urethra development namespace: biological_process def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph] is_a: GO:0061068 ! urethra development created_by: dph creation_date: 2010-03-12T08:29:43Z [Term] id: GO:0061071 name: urethra epithelium development namespace: biological_process def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0061068 ! urethra development created_by: dph creation_date: 2010-03-12T08:36:53Z [Term] id: GO:0061072 name: iris morphogenesis namespace: biological_process def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2010-03-16T10:48:42Z [Term] id: GO:0061073 name: ciliary body morphogenesis namespace: biological_process def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2010-03-16T10:55:19Z [Term] id: GO:0061074 name: regulation of neural retina development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003407 ! neural retina development relationship: regulates GO:0003407 ! neural retina development created_by: dph creation_date: 2010-03-16T11:47:05Z [Term] id: GO:0061075 name: positive regulation of neural retina development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902868 ! positive regulation of retina development in camera-type eye intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003407 ! neural retina development relationship: positively_regulates GO:0003407 ! neural retina development created_by: dph creation_date: 2010-03-16T11:59:48Z [Term] id: GO:0061076 name: negative regulation of neural retina development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902867 ! negative regulation of retina development in camera-type eye intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003407 ! neural retina development relationship: negatively_regulates GO:0003407 ! neural retina development created_by: dph creation_date: 2010-03-16T12:46:11Z [Term] id: GO:0061077 name: chaperone-mediated protein folding namespace: biological_process def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] is_a: GO:0006457 ! protein folding created_by: dph creation_date: 2010-04-06T03:28:55Z [Term] id: GO:0061078 name: positive regulation of prostaglandin secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of prostaglandin secretion during immune response" RELATED [GOC:dph] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0032308 ! positive regulation of prostaglandin secretion is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response relationship: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response created_by: dph creation_date: 2010-04-08T01:53:45Z [Term] id: GO:0061079 name: left horn of sinus venosus development namespace: biological_process def: "The progression of the left horn of the sinus venosus from its initial formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003235 ! sinus venosus development created_by: dph creation_date: 2010-04-08T02:40:27Z [Term] id: GO:0061080 name: right horn of sinus venosus development namespace: biological_process def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003235 ! sinus venosus development created_by: dph creation_date: 2010-04-08T02:45:10Z [Term] id: GO:0061081 name: positive regulation of myeloid leukocyte cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production relationship: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production created_by: dph creation_date: 2010-04-13T11:26:41Z [Term] id: GO:0061082 name: myeloid leukocyte cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph] is_a: GO:0002367 ! cytokine production involved in immune response created_by: dph creation_date: 2010-04-13T11:29:42Z [Term] id: GO:0061083 name: regulation of protein refolding namespace: biological_process def: "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:dph, GOC:tb] is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042026 ! protein refolding relationship: regulates GO:0042026 ! protein refolding created_by: dph creation_date: 2010-04-26T01:07:54Z [Term] id: GO:0061084 name: negative regulation of protein refolding namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0061083 ! regulation of protein refolding is_a: GO:1903333 ! negative regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042026 ! protein refolding relationship: negatively_regulates GO:0042026 ! protein refolding created_by: dph creation_date: 2010-04-26T01:11:29Z [Term] id: GO:0061085 name: regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070734 ! histone H3-K27 methylation relationship: regulates GO:0070734 ! histone H3-K27 methylation created_by: dph creation_date: 2010-04-26T01:23:52Z [Term] id: GO:0061086 name: negative regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0061085 ! regulation of histone H3-K27 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070734 ! histone H3-K27 methylation relationship: negatively_regulates GO:0070734 ! histone H3-K27 methylation created_by: dph creation_date: 2010-04-26T01:23:52Z [Term] id: GO:0061087 name: positive regulation of histone H3-K27 methylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0061085 ! regulation of histone H3-K27 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070734 ! histone H3-K27 methylation relationship: positively_regulates GO:0070734 ! histone H3-K27 methylation created_by: dph creation_date: 2010-04-26T01:23:52Z [Term] id: GO:0061088 name: regulation of sequestering of zinc ion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process is_a: GO:0050801 ! ion homeostasis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032119 ! sequestering of zinc ion relationship: regulates GO:0032119 ! sequestering of zinc ion created_by: dph creation_date: 2010-04-26T01:38:53Z [Term] id: GO:0061089 name: negative regulation of sequestering of zinc ion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0061088 ! regulation of sequestering of zinc ion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032119 ! sequestering of zinc ion relationship: negatively_regulates GO:0032119 ! sequestering of zinc ion created_by: dph creation_date: 2010-04-26T01:38:53Z [Term] id: GO:0061090 name: positive regulation of sequestering of zinc ion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0061088 ! regulation of sequestering of zinc ion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032119 ! sequestering of zinc ion relationship: positively_regulates GO:0032119 ! sequestering of zinc ion created_by: dph creation_date: 2010-04-26T01:38:53Z [Term] id: GO:0061091 name: regulation of phospholipid translocation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0097035 ! regulation of membrane lipid distribution is_a: GO:2001138 ! regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045332 ! phospholipid translocation relationship: regulates GO:0045332 ! phospholipid translocation created_by: dph creation_date: 2010-04-26T01:54:22Z [Term] id: GO:0061092 name: positive regulation of phospholipid translocation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0061091 ! regulation of phospholipid translocation is_a: GO:2001140 ! positive regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045332 ! phospholipid translocation relationship: positively_regulates GO:0045332 ! phospholipid translocation created_by: dph creation_date: 2010-04-26T01:54:22Z [Term] id: GO:0061093 name: negative regulation of phospholipid translocation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0061091 ! regulation of phospholipid translocation is_a: GO:2001139 ! negative regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045332 ! phospholipid translocation relationship: negatively_regulates GO:0045332 ! phospholipid translocation created_by: dph creation_date: 2010-04-26T01:54:22Z [Term] id: GO:0061094 name: regulation of turning behavior involved in mating namespace: biological_process def: "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:1902435 ! regulation of male mating behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034607 ! turning behavior involved in mating relationship: regulates GO:0034607 ! turning behavior involved in mating created_by: dph creation_date: 2010-04-26T02:12:24Z [Term] id: GO:0061095 name: positive regulation of turning behavior involved in mating namespace: biological_process def: "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:0061094 ! regulation of turning behavior involved in mating is_a: GO:1902437 ! positive regulation of male mating behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034607 ! turning behavior involved in mating relationship: positively_regulates GO:0034607 ! turning behavior involved in mating created_by: dph creation_date: 2010-04-26T02:12:24Z [Term] id: GO:0061096 name: negative regulation of turning behavior involved in mating namespace: biological_process def: "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] is_a: GO:0061094 ! regulation of turning behavior involved in mating is_a: GO:1902436 ! negative regulation of male mating behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034607 ! turning behavior involved in mating relationship: negatively_regulates GO:0034607 ! turning behavior involved in mating created_by: dph creation_date: 2010-04-26T02:12:24Z [Term] id: GO:0061097 name: regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004713 ! protein tyrosine kinase activity relationship: regulates GO:0004713 ! protein tyrosine kinase activity created_by: dph creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061098 name: positive regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004713 ! protein tyrosine kinase activity relationship: positively_regulates GO:0004713 ! protein tyrosine kinase activity created_by: dph creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061099 name: negative regulation of protein tyrosine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004713 ! protein tyrosine kinase activity relationship: negatively_regulates GO:0004713 ! protein tyrosine kinase activity created_by: dph creation_date: 2010-04-26T02:34:53Z [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] is_a: GO:0061101 ! neuroendocrine cell differentiation is_a: GO:0061140 ! lung secretory cell differentiation created_by: dph creation_date: 2010-04-27T03:28:46Z [Term] id: GO:0061101 name: neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] is_a: GO:0060563 ! neuroepithelial cell differentiation created_by: dph creation_date: 2010-04-28T09:42:20Z [Term] id: GO:0061102 name: stomach neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746] synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph] is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0062094 ! stomach development created_by: dph creation_date: 2010-04-28T09:47:07Z [Term] id: GO:0061103 name: carotid body glomus cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386] is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0048513 ! animal organ development created_by: dph creation_date: 2010-04-28T10:59:24Z [Term] id: GO:0061104 name: adrenal chromaffin cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph] is_a: GO:0002067 ! glandular epithelial cell differentiation is_a: GO:0061101 ! neuroendocrine cell differentiation relationship: part_of GO:0030325 ! adrenal gland development created_by: dph creation_date: 2010-04-29T08:27:53Z [Term] id: GO:0061105 name: regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061102 ! stomach neuroendocrine cell differentiation relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation created_by: dph creation_date: 2010-04-29T12:19:37Z [Term] id: GO:0061106 name: negative regulation of stomach neuroendocrine cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation created_by: dph creation_date: 2010-04-29T12:23:05Z [Term] id: GO:0061107 name: seminal vesicle development namespace: biological_process def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development created_by: dph creation_date: 2010-04-30T10:17:30Z [Term] id: GO:0061108 name: seminal vesicle epithelium development namespace: biological_process def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0061107 ! seminal vesicle development created_by: dph creation_date: 2010-04-30T10:19:54Z [Term] id: GO:0061109 name: dense core granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] synonym: "dense core granule organisation" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization created_by: dph creation_date: 2010-05-01T09:34:37Z [Term] id: GO:0061110 name: dense core granule biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule." [GOC:dph] is_a: GO:0044085 ! cellular component biogenesis created_by: dph creation_date: 2010-05-01T09:40:11Z [Term] id: GO:0061111 name: epithelial-mesenchymal cell signaling involved in lung development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: part_of GO:0030324 ! lung development created_by: dph creation_date: 2010-05-05T11:14:38Z [Term] id: GO:0061112 name: negative regulation of bud outgrowth involved in lung branching namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching." [GOC:dph] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061048 ! negative regulation of branching involved in lung morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching relationship: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching created_by: dph creation_date: 2010-05-05T11:20:42Z [Term] id: GO:0061113 name: pancreas morphogenesis namespace: biological_process def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0031016 ! pancreas development created_by: dph creation_date: 2010-05-05T11:55:30Z [Term] id: GO:0061114 name: branching involved in pancreas morphogenesis namespace: biological_process def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0061113 ! pancreas morphogenesis relationship: part_of GO:0061113 ! pancreas morphogenesis created_by: dph creation_date: 2010-05-05T12:03:04Z [Term] id: GO:0061115 name: lung proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli." [GOC:dph] is_a: GO:0009946 ! proximal/distal axis specification is_a: GO:0060432 ! lung pattern specification process created_by: dph creation_date: 2010-05-10T12:30:40Z [Term] id: GO:0061116 name: ductus venosus closure namespace: biological_process def: "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis created_by: dph creation_date: 2010-05-17T07:21:53Z [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060419 ! heart growth relationship: negatively_regulates GO:0060419 ! heart growth created_by: dph creation_date: 2010-05-17T07:31:28Z [Term] id: GO:0061118 name: regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050926 ! regulation of positive chemotaxis relationship: regulates GO:0043327 ! chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T07:47:47Z [Term] id: GO:0061119 name: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph, PMID:19684855] is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T07:53:58Z [Term] id: GO:0061120 name: regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:10:20Z [Term] id: GO:0061121 name: regulation of positive chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:16:21Z [Term] id: GO:0061122 name: positive regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050927 ! positive regulation of positive chemotaxis is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP relationship: positively_regulates GO:0043327 ! chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T08:25:55Z [Term] id: GO:0061123 name: negative regulation of positive chemotaxis to cAMP namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] is_a: GO:0050928 ! negative regulation of positive chemotaxis is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP relationship: negatively_regulates GO:0043327 ! chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T08:27:20Z [Term] id: GO:0061124 name: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone is_a: GO:0061122 ! positive regulation of positive chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T08:33:40Z [Term] id: GO:0061125 name: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone is_a: GO:0061123 ! negative regulation of positive chemotaxis to cAMP created_by: dph creation_date: 2010-05-17T08:36:55Z [Term] id: GO:0061126 name: positive regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:41:04Z [Term] id: GO:0061127 name: negative regulation of positive chemotaxis to cAMP by DIF-1 namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:45:03Z [Term] id: GO:0061128 name: positive regulation of chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:48:17Z [Term] id: GO:0061129 name: negative regulation of positive chemotaxis to cAMP by DIF-2 namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone created_by: dph creation_date: 2010-05-17T08:50:33Z [Term] id: GO:0061130 name: pancreatic bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] is_a: GO:0048645 ! animal organ formation is_a: GO:0061114 ! branching involved in pancreas morphogenesis is_a: GO:0072175 ! epithelial tube formation created_by: dph creation_date: 2010-05-17T09:33:40Z [Term] id: GO:0061131 name: pancreas field specification namespace: biological_process def: "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop." [GOC:dph] is_a: GO:0010092 ! specification of animal organ identity relationship: part_of GO:0061130 ! pancreatic bud formation created_by: dph creation_date: 2010-05-17T09:39:49Z [Term] id: GO:0061132 name: pancreas induction namespace: biological_process def: "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas." [GOC:dph] is_a: GO:0001759 ! organ induction is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905278 ! positive regulation of epithelial tube formation intersection_of: GO:0001759 ! organ induction intersection_of: positively_regulates GO:0061131 ! pancreas field specification relationship: positively_regulates GO:0061131 ! pancreas field specification created_by: dph creation_date: 2010-05-17T09:45:32Z [Term] id: GO:0061133 name: endopeptidase activator activity namespace: molecular_function def: "Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] is_a: GO:0016504 ! peptidase activator activity is_a: GO:0061135 ! endopeptidase regulator activity relationship: part_of GO:0010950 ! positive regulation of endopeptidase activity relationship: positively_regulates GO:0004175 ! endopeptidase activity created_by: dph creation_date: 2010-05-17T01:08:29Z [Term] id: GO:0061134 name: peptidase regulator activity namespace: molecular_function def: "Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity relationship: has_part GO:0002020 ! protease binding relationship: part_of GO:0052547 ! regulation of peptidase activity relationship: regulates GO:0008233 ! peptidase activity created_by: dph creation_date: 2010-05-17T01:15:24Z [Term] id: GO:0061135 name: endopeptidase regulator activity namespace: molecular_function def: "Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] is_a: GO:0061134 ! peptidase regulator activity relationship: part_of GO:0052548 ! regulation of endopeptidase activity relationship: regulates GO:0004175 ! endopeptidase activity created_by: dph creation_date: 2010-05-17T01:19:36Z [Term] id: GO:0061136 name: regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010498 ! proteasomal protein catabolic process relationship: regulates GO:0010498 ! proteasomal protein catabolic process created_by: dph creation_date: 2010-05-17T01:33:20Z [Term] id: GO:0061137 name: bud dilation namespace: biological_process def: "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch." [GOC:dph] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0001763 ! morphogenesis of a branching structure created_by: dph creation_date: 2010-05-20T07:54:42Z [Term] id: GO:0061138 name: morphogenesis of a branching epithelium namespace: biological_process def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0002009 ! morphogenesis of an epithelium created_by: dph creation_date: 2010-05-25T09:05:34Z [Term] id: GO:0061139 name: bud field specification namespace: biological_process def: "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph] is_a: GO:0003002 ! regionalization relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium created_by: dph creation_date: 2010-05-25T09:21:01Z [Term] id: GO:0061140 name: lung secretory cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation created_by: dph creation_date: 2010-05-25T09:28:53Z [Term] id: GO:0061141 name: lung ciliated cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells." [GOC:cilia, GOC:dph, GOC:krc] is_a: GO:0060487 ! lung epithelial cell differentiation created_by: dph creation_date: 2010-05-25T09:31:14Z [Term] id: GO:0061142 name: mesothelial-mesenchymal cell signaling involved in early lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung." [GOC:dph] synonym: "mesothelial-mesenchymal cell signalling involved in early lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development created_by: dph creation_date: 2010-05-25T09:35:32Z [Term] id: GO:0061143 name: alveolar primary septum development namespace: biological_process def: "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms." [GOC:dph] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060430 ! lung saccule development created_by: dph creation_date: 2010-05-25T10:21:27Z [Term] id: GO:0061144 name: alveolar secondary septum development namespace: biological_process def: "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule." [GOC:dph] is_a: GO:0060428 ! lung epithelium development relationship: part_of GO:0060430 ! lung saccule development created_by: dph creation_date: 2010-05-25T10:43:55Z [Term] id: GO:0061145 name: lung smooth muscle development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0030324 ! lung development created_by: dph creation_date: 2010-05-25T10:46:35Z [Term] id: GO:0061146 name: Peyer's patch morphogenesis namespace: biological_process def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048541 ! Peyer's patch development created_by: dph creation_date: 2010-05-26T06:46:23Z [Term] id: GO:0061147 name: endocardial endothelium development namespace: biological_process def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0003158 ! endothelium development relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2010-06-03T09:15:31Z [Term] id: GO:0061148 name: extracellular matrix organization involved in endocardium development namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0030198 ! extracellular matrix organization intersection_of: part_of GO:0003157 ! endocardium development relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2010-06-03T09:18:02Z [Term] id: GO:0061149 name: BMP signaling pathway involved in ureter morphogenesis namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "BMP signalling pathway involved in ureter morphogenesis" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0072197 ! ureter morphogenesis relationship: part_of GO:0072197 ! ureter morphogenesis created_by: dph creation_date: 2010-06-02T09:11:46Z [Term] id: GO:0061150 name: renal system segmentation namespace: biological_process def: "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis." [GOC:dph, GOC:yaf] synonym: "urinary tract segmentation" EXACT [GOC:dph] is_a: GO:0035282 ! segmentation is_a: GO:0072048 ! renal system pattern specification created_by: dph creation_date: 2010-06-02T09:23:01Z [Term] id: GO:0061151 name: BMP signaling pathway involved in renal system segmentation namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system." [GOC:dph, GOC:yaf] synonym: "BMP signalling pathway involved in renal system segmentation" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0061150 ! renal system segmentation relationship: part_of GO:0061150 ! renal system segmentation created_by: dph creation_date: 2010-06-02T09:29:43Z [Term] id: GO:0061152 name: trachea submucosa development namespace: biological_process def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060438 ! trachea development created_by: dph creation_date: 2010-06-07T09:58:40Z [Term] id: GO:0061153 name: trachea gland development namespace: biological_process def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0061152 ! trachea submucosa development created_by: dph creation_date: 2010-06-07T10:10:51Z [Term] id: GO:0061154 name: endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf] is_a: GO:0003159 ! morphogenesis of an endothelium is_a: GO:0060562 ! epithelial tube morphogenesis created_by: dph creation_date: 2010-06-15T09:05:00Z [Term] id: GO:0061155 name: pulmonary artery endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf] is_a: GO:0061154 ! endothelial tube morphogenesis relationship: part_of GO:0061156 ! pulmonary artery morphogenesis created_by: dph creation_date: 2010-06-15T09:09:04Z [Term] id: GO:0061156 name: pulmonary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf] is_a: GO:0048844 ! artery morphogenesis created_by: dph creation_date: 2010-06-15T09:13:47Z [Term] id: GO:0061157 name: mRNA destabilization namespace: biological_process def: "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043488 ! regulation of mRNA stability is_a: GO:0050779 ! RNA destabilization is_a: GO:0061014 ! positive regulation of mRNA catabolic process created_by: dph creation_date: 2010-06-22T08:42:10Z [Term] id: GO:0061158 name: 3'-UTR-mediated mRNA destabilization namespace: biological_process def: "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh] is_a: GO:0061157 ! mRNA destabilization created_by: dph creation_date: 2010-06-22T08:44:39Z [Term] id: GO:0061159 name: establishment of bipolar cell polarity involved in cell morphogenesis namespace: biological_process def: "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:0061171 ! establishment of bipolar cell polarity intersection_of: GO:0061171 ! establishment of bipolar cell polarity intersection_of: part_of GO:0000902 ! cell morphogenesis relationship: part_of GO:0000902 ! cell morphogenesis created_by: dph creation_date: 2010-06-23T09:14:39Z [Term] id: GO:0061160 name: regulation of establishment of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-06-23T09:21:36Z [Term] id: GO:0061161 name: positive regulation of establishment of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0061160 ! regulation of establishment of bipolar cell polarity regulating cell shape is_a: GO:0061173 ! positive regulation of establishment of bipolar cell polarity is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-06-23T09:26:45Z [Term] id: GO:0061162 name: establishment of monopolar cell polarity namespace: biological_process def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity created_by: dph creation_date: 2010-06-23T09:30:59Z [Term] id: GO:0061163 name: endoplasmic reticulum polarization namespace: biological_process def: "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell." [GOC:dph, GOC:vw] is_a: GO:0007029 ! endoplasmic reticulum organization is_a: GO:0007163 ! establishment or maintenance of cell polarity created_by: dph creation_date: 2010-06-25T09:51:48Z [Term] id: GO:0061164 name: transitional endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The endoplasmic reticulum polarization process that results in the structure being polarized at the site of future cell division." [GOC:dph, GOC:vw] is_a: GO:0061163 ! endoplasmic reticulum polarization created_by: dph creation_date: 2010-06-25T09:56:51Z [Term] id: GO:0061165 name: endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The process in which endoplasmic reticulum is transiently localized to the site where a cell will divide." [GOC:dph, GOC:vw] synonym: "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah] synonym: "ER localization involved in ER polarization at cell division site" EXACT [GOC:dph] is_a: GO:0051643 ! endoplasmic reticulum localization intersection_of: GO:0051643 ! endoplasmic reticulum localization intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site relationship: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site created_by: dph creation_date: 2010-06-25T10:11:09Z [Term] id: GO:0061166 name: establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The directed movement of the endoplasmic reticulum to the site where a cell will divide." [GOC:dph, GOC:vw] synonym: "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" EXACT [GOC:mah] is_a: GO:0051686 ! establishment of ER localization is_a: GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site intersection_of: GO:0051686 ! establishment of ER localization intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site created_by: dph creation_date: 2010-06-25T10:16:34Z [Term] id: GO:0061167 name: maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site namespace: biological_process def: "The process in which the endoplasmic reticulum is maintained at the site of cell division and is prevented from moving elsewhere." [GOC:dph, GOC:vw] is_a: GO:0051685 ! maintenance of ER location is_a: GO:0061165 ! endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site intersection_of: GO:0051685 ! maintenance of ER location intersection_of: part_of GO:0061164 ! transitional endoplasmic reticulum polarization at cell division site created_by: dph creation_date: 2010-06-25T10:18:36Z [Term] id: GO:0061168 name: regulation of hair follicle placode formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051797 ! regulation of hair follicle development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060789 ! hair follicle placode formation relationship: regulates GO:0060789 ! hair follicle placode formation created_by: dph creation_date: 2010-06-25T01:03:29Z [Term] id: GO:0061169 name: positive regulation of hair placode formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051798 ! positive regulation of hair follicle development is_a: GO:0061168 ! regulation of hair follicle placode formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060789 ! hair follicle placode formation relationship: positively_regulates GO:0060789 ! hair follicle placode formation created_by: dph creation_date: 2010-06-25T01:08:50Z [Term] id: GO:0061170 name: negative regulation of hair follicle placode formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] is_a: GO:0051799 ! negative regulation of hair follicle development is_a: GO:0061168 ! regulation of hair follicle placode formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060789 ! hair follicle placode formation relationship: negatively_regulates GO:0060789 ! hair follicle placode formation created_by: dph creation_date: 2010-06-25T01:10:48Z [Term] id: GO:0061171 name: establishment of bipolar cell polarity namespace: biological_process def: "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:0030010 ! establishment of cell polarity created_by: dph creation_date: 2010-06-30T08:49:38Z [Term] id: GO:0061172 name: regulation of establishment of bipolar cell polarity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] is_a: GO:2000114 ! regulation of establishment of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061171 ! establishment of bipolar cell polarity relationship: regulates GO:0061171 ! establishment of bipolar cell polarity created_by: dph creation_date: 2010-06-30T08:51:27Z [Term] id: GO:0061173 name: positive regulation of establishment of bipolar cell polarity namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity." [GOC:dph, GOC:vw] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061171 ! establishment of bipolar cell polarity relationship: positively_regulates GO:0061171 ! establishment of bipolar cell polarity created_by: dph creation_date: 2010-06-30T08:59:20Z [Term] id: GO:0061174 name: type I terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] synonym: "type I terminal button" EXACT [GOC:dph] is_a: GO:0043195 ! terminal bouton created_by: dph creation_date: 2010-07-13T09:13:05Z [Term] id: GO:0061175 name: type II terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] synonym: "type II terminal button" EXACT [GOC:dph] is_a: GO:0043195 ! terminal bouton created_by: dph creation_date: 2010-07-13T09:18:01Z [Term] id: GO:0061176 name: type Ib terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc] synonym: "type Ib terminal button" EXACT [GOC:dph] is_a: GO:0061174 ! type I terminal bouton created_by: dph creation_date: 2010-07-13T09:20:04Z [Term] id: GO:0061177 name: type Is terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc] synonym: "type Is terminal button" RELATED [GOC:dph] is_a: GO:0061174 ! type I terminal bouton created_by: dph creation_date: 2010-07-13T09:25:15Z [Term] id: GO:0061178 name: regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus created_by: dph creation_date: 2010-07-13T09:38:42Z [Term] id: GO:0061179 name: negative regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph] synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] is_a: GO:0046676 ! negative regulation of insulin secretion is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus created_by: dph creation_date: 2010-07-13T09:41:46Z [Term] id: GO:0061180 name: mammary gland epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf] synonym: "breast epithelium development" EXACT [GOC:dph] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2010-07-14T08:18:24Z [Term] id: GO:0061181 name: regulation of chondrocyte development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002063 ! chondrocyte development relationship: regulates GO:0002063 ! chondrocyte development created_by: dph creation_date: 2010-07-14T08:28:52Z [Term] id: GO:0061182 name: negative regulation of chondrocyte development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0032331 ! negative regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002063 ! chondrocyte development relationship: negatively_regulates GO:0002063 ! chondrocyte development created_by: dph creation_date: 2010-07-14T08:33:05Z [Term] id: GO:0061183 name: regulation of dermatome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061054 ! dermatome development relationship: regulates GO:0061054 ! dermatome development created_by: dph creation_date: 2010-07-14T08:40:26Z [Term] id: GO:0061184 name: positive regulation of dermatome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061054 ! dermatome development relationship: positively_regulates GO:0061054 ! dermatome development created_by: dph creation_date: 2010-07-14T08:42:03Z [Term] id: GO:0061185 name: negative regulation of dermatome development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061054 ! dermatome development relationship: negatively_regulates GO:0061054 ! dermatome development created_by: dph creation_date: 2010-07-14T08:43:08Z [Term] id: GO:0061186 name: negative regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: negatively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: dph creation_date: 2010-07-14T08:59:11Z [Term] id: GO:0061187 name: regulation of chromatin silencing at rDNA namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031935 ! regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000183 ! chromatin silencing at rDNA relationship: regulates GO:0000183 ! chromatin silencing at rDNA created_by: dph creation_date: 2010-07-14T09:04:16Z [Term] id: GO:0061188 name: negative regulation of chromatin silencing at rDNA namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin." [GOC:dph, PMID:10388812] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0061187 ! regulation of chromatin silencing at rDNA intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000183 ! chromatin silencing at rDNA relationship: negatively_regulates GO:0000183 ! chromatin silencing at rDNA created_by: dph creation_date: 2010-07-14T09:07:59Z [Term] id: GO:0061189 name: positive regulation of sclerotome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061190 ! regulation of sclerotome development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061056 ! sclerotome development relationship: positively_regulates GO:0061056 ! sclerotome development created_by: dph creation_date: 2010-07-14T09:17:23Z [Term] id: GO:0061190 name: regulation of sclerotome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061056 ! sclerotome development relationship: regulates GO:0061056 ! sclerotome development created_by: dph creation_date: 2010-07-14T09:19:47Z [Term] id: GO:0061191 name: positive regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic is_a: GO:0044090 ! positive regulation of vacuole organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic relationship: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic created_by: dph creation_date: 2010-07-14T09:33:31Z [Term] id: GO:0061192 name: negative regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic relationship: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic created_by: dph creation_date: 2010-07-14T09:35:18Z [Term] id: GO:0061193 name: taste bud development namespace: biological_process def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0043586 ! tongue development created_by: dph creation_date: 2010-07-27T10:55:08Z [Term] id: GO:0061194 name: taste bud morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0043587 ! tongue morphogenesis relationship: part_of GO:0061193 ! taste bud development created_by: dph creation_date: 2010-07-27T11:01:31Z [Term] id: GO:0061195 name: taste bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0061194 ! taste bud morphogenesis created_by: dph creation_date: 2010-07-27T12:22:26Z [Term] id: GO:0061196 name: fungiform papilla development namespace: biological_process def: "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043586 ! tongue development created_by: dph creation_date: 2010-07-27T12:23:48Z [Term] id: GO:0061197 name: fungiform papilla morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0043587 ! tongue morphogenesis relationship: part_of GO:0061196 ! fungiform papilla development created_by: dph creation_date: 2010-07-27T12:26:40Z [Term] id: GO:0061198 name: fungiform papilla formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0061197 ! fungiform papilla morphogenesis created_by: dph creation_date: 2010-07-27T12:29:03Z [Term] id: GO:0061199 name: striated muscle contraction involved in embryonic body morphogenesis namespace: biological_process def: "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology." [GOC:dph, GOC:kmv] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006941 ! striated muscle contraction intersection_of: part_of GO:0010172 ! embryonic body morphogenesis relationship: part_of GO:0010172 ! embryonic body morphogenesis created_by: dph creation_date: 2010-07-28T04:07:23Z [Term] id: GO:0061200 name: clathrin-sculpted gamma-aminobutyric acid transport vesicle namespace: cellular_component def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle" EXACT [GOC:dph] synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle" EXACT [GOC:sl] is_a: GO:0060198 ! clathrin-sculpted vesicle created_by: dph creation_date: 2010-07-29T10:40:43Z [Term] id: GO:0061201 name: clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle lumen" EXACT [GOC:dph] synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle lumen" EXACT [GOC:sl] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle created_by: dph creation_date: 2010-07-29T10:45:05Z [Term] id: GO:0061202 name: clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] synonym: "clathrin sculpted GABA transport vesicle membrane" EXACT [GOC:dph] synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle membrane" EXACT [GOC:sl] is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle created_by: dph creation_date: 2010-07-29T10:54:33Z [Term] id: GO:0061203 name: striated muscle paramyosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle." [GOC:dph, GOC:kmv] is_a: GO:0061204 ! paramyosin filament assembly or disassembly relationship: part_of GO:0030239 ! myofibril assembly created_by: dph creation_date: 2010-07-29T12:22:31Z [Term] id: GO:0061204 name: paramyosin filament assembly or disassembly namespace: biological_process def: "The formation or disassembly of a filament composed of paramyosin molecules." [GOC:dph, GOC:kmv] is_a: GO:0030036 ! actin cytoskeleton organization created_by: dph creation_date: 2010-07-29T12:26:38Z [Term] id: GO:0061205 name: paramesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf] synonym: "Mullerian duct development" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035295 ! tube development created_by: dph creation_date: 2010-07-30T10:54:47Z [Term] id: GO:0061206 name: mesonephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10] synonym: "Wolffian body morphogenesis" EXACT [GOC:dph] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:11:10Z [Term] id: GO:0061207 name: mesonephric juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072052 ! juxtaglomerulus cell differentiation relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development created_by: dph creation_date: 2010-08-19T12:54:08Z [Term] id: GO:0061208 name: cell differentiation involved in mesonephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0001823 ! mesonephros development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:21:23Z [Term] id: GO:0061209 name: cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001823 ! mesonephros development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:22:46Z [Term] id: GO:0061210 name: cell-cell signaling involved in mesonephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0001823 ! mesonephros development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:24:08Z [Term] id: GO:0061211 name: mesonephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:25:51Z [Term] id: GO:0061212 name: mesonephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:27:36Z [Term] id: GO:0061213 name: positive regulation of mesonephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090184 ! positive regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001823 ! mesonephros development relationship: positively_regulates GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:39:35Z [Term] id: GO:0061214 name: mesonephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:29:54Z [Term] id: GO:0061215 name: mesonephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:31:08Z [Term] id: GO:0061216 name: regulation of transcription from RNA polymerase II promoter involved in mesonephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0001823 ! mesonephros development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:32:27Z [Term] id: GO:0061217 name: regulation of mesonephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001823 ! mesonephros development relationship: regulates GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:35:31Z [Term] id: GO:0061218 name: negative regulation of mesonephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090185 ! negative regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001823 ! mesonephros development relationship: negatively_regulates GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:43:06Z [Term] id: GO:0061219 name: mesonephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-17T03:45:44Z [Term] id: GO:0061220 name: mesonephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072024 ! macula densa development relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development created_by: dph creation_date: 2010-08-19T01:11:41Z [Term] id: GO:0061221 name: mesonephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0061219 ! mesonephric mesenchyme development created_by: dph creation_date: 2010-08-19T01:17:38Z [Term] id: GO:0061222 name: mesonephric mesenchymal cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population." [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072135 ! kidney mesenchymal cell proliferation relationship: part_of GO:0061219 ! mesonephric mesenchyme development created_by: dph creation_date: 2010-08-19T01:20:14Z [Term] id: GO:0061223 name: mesonephric mesenchymal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development relationship: part_of GO:0061219 ! mesonephric mesenchyme development created_by: dph creation_date: 2010-08-19T01:21:48Z [Term] id: GO:0061224 name: mesonephric glomerulus development namespace: biological_process def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-08-19T01:26:00Z [Term] id: GO:0061225 name: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "mesonephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "mesonephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072122 ! extraglomerular mesangial cell proliferation relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-08-19T01:34:59Z [Term] id: GO:0061226 name: proximal/distal pattern formation involved in mesonephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end)." [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-08-19T02:10:25Z [Term] id: GO:0061227 name: pattern specification involved in mesonephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: part_of GO:0001823 ! mesonephros development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-08-19T02:22:22Z [Term] id: GO:0061228 name: mesonephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0061206 ! mesonephros morphogenesis relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-08-19T02:26:24Z [Term] id: GO:0061229 name: mesonephric juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072142 ! juxtaglomerulus cell development relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation created_by: dph creation_date: 2010-08-19T02:34:25Z [Term] id: GO:0061230 name: mesonephric juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0072150 ! juxtaglomerulus cell fate commitment relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation created_by: dph creation_date: 2010-08-19T02:36:23Z [Term] id: GO:0061231 name: mesonephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-08-19T02:47:06Z [Term] id: GO:0061232 name: mesonephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072010 ! glomerular epithelium development relationship: part_of GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-08-19T02:49:46Z [Term] id: GO:0061233 name: mesonephric glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] is_a: GO:0032836 ! glomerular basement membrane development relationship: part_of GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-08-19T02:52:18Z [Term] id: GO:0061234 name: mesonephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0061224 ! mesonephric glomerulus development relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T02:53:35Z [Term] id: GO:0061235 name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T02:57:11Z [Term] id: GO:0061236 name: mesonephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:00:21Z [Term] id: GO:0061237 name: convergent extension involved in mesonephric nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:02:44Z [Term] id: GO:0061238 name: establishment of planar polarity involved in mesonephric nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in mesonephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis intersection_of: GO:0001736 ! establishment of planar polarity intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:04:40Z [Term] id: GO:0061239 name: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:06:46Z [Term] id: GO:0061240 name: mesonephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072171 ! mesonephric tubule morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis relationship: part_of GO:0061242 ! mesonephric nephron tubule development created_by: dph creation_date: 2010-08-19T03:09:26Z [Term] id: GO:0061241 name: mesonephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072163 ! mesonephric epithelium development relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-08-19T03:11:59Z [Term] id: GO:0061242 name: mesonephric nephron tubule development namespace: biological_process def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061241 ! mesonephric nephron epithelium development is_a: GO:0072080 ! nephron tubule development is_a: GO:0072164 ! mesonephric tubule development created_by: dph creation_date: 2010-08-19T03:17:00Z [Term] id: GO:0061243 name: mesonephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:20:21Z [Term] id: GO:0061244 name: mesonephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: dph creation_date: 2010-08-19T03:23:55Z [Term] id: GO:0061245 name: establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity created_by: dph creation_date: 2010-08-23T09:42:05Z [Term] id: GO:0061246 name: establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell." [GOC:dph, GOC:vw] is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: dph creation_date: 2010-08-23T09:46:01Z [Term] id: GO:0061247 name: mesonephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development created_by: dph creation_date: 2010-08-30T12:59:25Z [Term] id: GO:0061248 name: mesonephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development relationship: part_of GO:0061234 ! mesonephric glomerulus morphogenesis created_by: dph creation_date: 2010-08-30T01:11:34Z [Term] id: GO:0061249 name: mesonephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation relationship: part_of GO:0061248 ! mesonephric glomerulus vasculature morphogenesis created_by: dph creation_date: 2010-08-30T01:17:08Z [Term] id: GO:0061250 name: mesonephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: part_of GO:0061232 ! mesonephric glomerular epithelium development created_by: dph creation_date: 2010-08-30T01:20:03Z [Term] id: GO:0061251 name: mesonephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation created_by: dph creation_date: 2010-08-30T01:20:45Z [Term] id: GO:0061252 name: mesonephric glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation created_by: dph creation_date: 2010-08-30T01:23:50Z [Term] id: GO:0061253 name: mesonephric glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation created_by: dph creation_date: 2010-08-30T01:26:47Z [Term] id: GO:0061254 name: mesonephric glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072016 ! glomerular parietal epithelial cell development relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation created_by: dph creation_date: 2010-08-30T01:30:36Z [Term] id: GO:0061255 name: mesonephric glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] is_a: GO:0061252 ! mesonephric glomerular epithelial cell fate commitment is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation created_by: dph creation_date: 2010-08-30T01:33:52Z [Term] id: GO:0061256 name: mesonephric glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation created_by: dph creation_date: 2010-08-30T02:03:38Z [Term] id: GO:0061257 name: mesonephric glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072015 ! glomerular visceral epithelial cell development relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation created_by: dph creation_date: 2010-08-30T02:10:40Z [Term] id: GO:0061258 name: mesonephric glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0061251 ! mesonephric glomerular epithelial cell development is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation created_by: dph creation_date: 2010-08-30T02:13:33Z [Term] id: GO:0061259 name: mesonephric glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061260 ! mesonephric mesangial cell differentiation is_a: GO:0072008 ! glomerular mesangial cell differentiation relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development created_by: dph creation_date: 2010-08-30T02:22:45Z [Term] id: GO:0061260 name: mesonephric mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072007 ! mesangial cell differentiation created_by: dph creation_date: 2010-08-30T02:25:08Z [Term] id: GO:0061261 name: mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition is_a: GO:0061208 ! cell differentiation involved in mesonephros development intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: part_of GO:0061206 ! mesonephros morphogenesis relationship: part_of GO:0061206 ! mesonephros morphogenesis created_by: dph creation_date: 2010-08-30T02:35:15Z [Term] id: GO:0061262 name: mesonephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis created_by: dph creation_date: 2010-08-30T02:41:20Z [Term] id: GO:0061263 name: mesonephric glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072144 ! glomerular mesangial cell development relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation created_by: dph creation_date: 2010-08-30T02:52:55Z [Term] id: GO:0061264 name: mesonephric glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072152 ! glomerular mesangial cell fate commitment relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation created_by: dph creation_date: 2010-08-30T02:59:11Z [Term] id: GO:0061265 name: mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072160 ! nephron tubule epithelial cell differentiation relationship: part_of GO:0061242 ! mesonephric nephron tubule development created_by: dph creation_date: 2010-08-30T03:02:09Z [Term] id: GO:0061266 name: mesonephric interstitial fibroblast differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "mesonephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072071 ! kidney interstitial fibroblast differentiation created_by: dph creation_date: 2010-08-30T03:12:17Z [Term] id: GO:0061267 name: mesonephric interstitial fibroblast development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "mesonephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072141 ! renal interstitial fibroblast development relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation created_by: dph creation_date: 2010-08-30T03:14:31Z [Term] id: GO:0061268 name: mesonephric interstitial fibroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast." [GOC:mtg_kidney_jan10] is_a: GO:0072153 ! renal interstitial fibroblast fate commitment relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation created_by: dph creation_date: 2010-08-30T03:16:52Z [Term] id: GO:0061269 name: mesonephric glomerular mesangial cell proliferation involved in mesonephros development namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0061209 ! cell proliferation involved in mesonephros development is_a: GO:0072110 ! glomerular mesangial cell proliferation relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development created_by: dph creation_date: 2010-08-30T03:20:57Z [Term] id: GO:0061270 name: mesonephric intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development is_a: GO:0072123 ! intraglomerular mesangial cell proliferation created_by: dph creation_date: 2010-08-30T03:23:10Z [Term] id: GO:0061271 name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: part_of GO:0061262 ! mesonephric renal vesicle formation relationship: part_of GO:0061262 ! mesonephric renal vesicle formation created_by: dph creation_date: 2010-08-30T03:26:30Z [Term] id: GO:0061272 name: mesonephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10] synonym: "mesonephric collecting tubule development" EXACT [GOC:dph] synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072027 ! connecting tubule development created_by: dph creation_date: 2010-09-02T12:00:56Z [Term] id: GO:0061273 name: mesonephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072156 ! distal tubule morphogenesis relationship: part_of GO:0061274 ! mesonephric distal tubule development created_by: dph creation_date: 2010-09-02T12:12:00Z [Term] id: GO:0061274 name: mesonephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072017 ! distal tubule development created_by: dph creation_date: 2010-09-02T12:16:25Z [Term] id: GO:0061275 name: mesonephric proximal tubule development namespace: biological_process def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061242 ! mesonephric nephron tubule development is_a: GO:0072014 ! proximal tubule development created_by: dph creation_date: 2010-09-02T01:08:05Z [Term] id: GO:0061276 name: mesonephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis is_a: GO:0072158 ! proximal tubule morphogenesis relationship: part_of GO:0061275 ! mesonephric proximal tubule development created_by: dph creation_date: 2010-09-02T01:11:02Z [Term] id: GO:0061277 name: mesonephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072172 ! mesonephric tubule formation relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:16:21Z [Term] id: GO:0061278 name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:18:53Z [Term] id: GO:0061279 name: epithelial cell migration involved in mesonephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0061273 ! mesonephric distal tubule morphogenesis relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:20:56Z [Term] id: GO:0061280 name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:23:43Z [Term] id: GO:0061281 name: specification of mesonephric connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] synonym: "specification of mesonephric collecting tubule identity" EXACT [GOC:dph] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072085 ! specification of connecting tubule identity relationship: part_of GO:0061272 ! mesonephric connecting tubule development created_by: dph creation_date: 2010-09-02T01:26:09Z [Term] id: GO:0061282 name: specification of mesonephric nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0061226 ! proximal/distal pattern formation involved in mesonephric nephron development relationship: part_of GO:0061277 ! mesonephric nephron tubule formation created_by: dph creation_date: 2010-09-02T01:37:44Z [Term] id: GO:0061283 name: specification of mesonephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072084 ! specification of distal tubule identity relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:42:10Z [Term] id: GO:0061284 name: specification of mesonephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0061282 ! specification of mesonephric nephron tubule identity is_a: GO:0072082 ! specification of proximal tubule identity relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis created_by: dph creation_date: 2010-09-02T01:44:24Z [Term] id: GO:0061285 name: mesonephric capsule development namespace: biological_process def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development relationship: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-09-02T01:50:06Z [Term] id: GO:0061286 name: mesonephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis relationship: part_of GO:0061285 ! mesonephric capsule development created_by: dph creation_date: 2010-09-02T01:53:31Z [Term] id: GO:0061287 name: mesonephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis created_by: dph creation_date: 2010-09-02T01:55:03Z [Term] id: GO:0061288 name: mesonephric capsule specification namespace: biological_process def: "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072130 ! renal capsule specification relationship: part_of GO:0061287 ! mesonephric capsule formation created_by: dph creation_date: 2010-09-02T01:56:20Z [Term] id: GO:0061289 name: Wnt signaling pathway involved in kidney development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time." [GOC:mtg_kidney_jan10] synonym: "Wnt receptor signaling pathway involved in kidney development" EXACT [] synonym: "Wnt receptor signalling pathway involved in kidney development" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in kidney development" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2010-09-03T12:04:50Z [Term] id: GO:0061290 name: canonical Wnt signaling pathway involved in metanephric kidney development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signaling pathway involved in metanephric kidney development" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in metanephric kidney development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in metanephric kidney development" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development is_a: GO:0072204 ! cell-cell signaling involved in metanephros development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0001656 ! metanephros development created_by: dph creation_date: 2010-09-03T12:06:10Z [Term] id: GO:0061291 name: canonical Wnt signaling pathway involved in ureteric bud branching namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signaling pathway involved in ureteric bud branching" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in ureteric bud branching" EXACT [GOC:mah] is_a: GO:0061290 ! canonical Wnt signaling pathway involved in metanephric kidney development is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: dph creation_date: 2010-09-03T12:15:19Z [Term] id: GO:0061292 name: canonical Wnt signaling pathway involved in mesonephros development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signaling pathway involved in mesonephros development" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in mesonephros development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in mesonephros development" EXACT [GOC:signaling] is_a: GO:0060070 ! canonical Wnt signaling pathway is_a: GO:0061210 ! cell-cell signaling involved in mesonephros development is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0001823 ! mesonephros development created_by: dph creation_date: 2010-09-03T12:23:09Z [Term] id: GO:0061293 name: canonical Wnt signaling pathway involved in mesonephric nephron development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] synonym: "canonical Wnt receptor signaling pathway involved in mesonephric nephron development" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in mesonephric nephron development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in mesonephric nephron development" EXACT [GOC:signaling] is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0061215 ! mesonephric nephron development relationship: part_of GO:0061215 ! mesonephric nephron development created_by: dph creation_date: 2010-09-03T12:49:43Z [Term] id: GO:0061294 name: mesonephric renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0072034 ! renal vesicle induction relationship: positively_regulates GO:0061262 ! mesonephric renal vesicle formation created_by: dph creation_date: 2010-09-03T12:57:59Z [Term] id: GO:0061295 name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis created_by: dph creation_date: 2010-09-06T09:48:56Z [Term] id: GO:0061296 name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis created_by: dph creation_date: 2010-09-06T09:54:49Z [Term] id: GO:0061297 name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis relationship: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis created_by: dph creation_date: 2010-09-06T09:58:59Z [Term] id: GO:0061298 name: retina vasculature development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] synonym: "retinal vasculature development" EXACT [GOC:dph] is_a: GO:0001944 ! vasculature development relationship: part_of GO:0060041 ! retina development in camera-type eye created_by: dph creation_date: 2010-09-06T03:27:06Z [Term] id: GO:0061299 name: retina vasculature morphogenesis in camera-type eye namespace: biological_process def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye created_by: dph creation_date: 2010-09-06T03:28:25Z [Term] id: GO:0061300 name: cerebellum vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0001944 ! vasculature development created_by: dph creation_date: 2010-09-06T03:36:40Z [Term] id: GO:0061301 name: cerebellum vasculature morphogenesis namespace: biological_process def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0061300 ! cerebellum vasculature development created_by: dph creation_date: 2010-09-06T03:38:05Z [Term] id: GO:0061302 name: smooth muscle cell-matrix adhesion namespace: biological_process def: "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules." [GOC:BHF, GOC:dph, PMID:8837777] is_a: GO:0007160 ! cell-matrix adhesion created_by: dph creation_date: 2010-09-14T11:08:00Z [Term] id: GO:0061303 name: cornea development in camera-type eye namespace: biological_process def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development created_by: dph creation_date: 2010-09-14T02:09:08Z [Term] id: GO:0061304 name: retinal blood vessel morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye created_by: dph creation_date: 2010-09-16T09:02:59Z [Term] id: GO:0061305 name: maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell." [GOC:dph, GOC:vw] is_a: GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-09-16T09:25:18Z [Term] id: GO:0061306 name: DNA strand renaturation involved in double-strand break repair namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair." [GOC:dph] is_a: GO:0000733 ! DNA strand renaturation intersection_of: GO:0000733 ! DNA strand renaturation intersection_of: part_of GO:0006302 ! double-strand break repair relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing created_by: dph creation_date: 2010-09-21T09:36:47Z [Term] id: GO:0061307 name: cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] is_a: GO:0014033 ! neural crest cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T08:50:56Z [Term] id: GO:0061308 name: cardiac neural crest cell development involved in heart development namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0014032 ! neural crest cell development intersection_of: GO:0014032 ! neural crest cell development intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development created_by: dph creation_date: 2010-09-23T09:01:49Z [Term] id: GO:0061309 name: cardiac neural crest cell development involved in outflow tract morphogenesis namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development intersection_of: GO:0014032 ! neural crest cell development intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2010-09-23T09:08:37Z [Term] id: GO:0061310 name: canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation." [GOC:dph, GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling] is_a: GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development created_by: dph creation_date: 2010-09-23T09:12:36Z [Term] id: GO:0061311 name: cell surface receptor signaling pathway involved in heart development namespace: biological_process def: "Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T09:18:32Z [Term] id: GO:0061312 name: BMP signaling pathway involved in heart development namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-23T11:02:14Z [Term] id: GO:0061313 name: fibroblast growth factor receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-24T08:15:08Z [Term] id: GO:0061314 name: Notch signaling involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time." [GOC:mtg_heart] synonym: "Notch signalling involved in heart development" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-24T08:25:22Z [Term] id: GO:0061315 name: canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:signaling] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation relationship: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation created_by: dph creation_date: 2010-09-24T08:53:58Z [Term] id: GO:0061316 name: canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003306 ! Wnt signaling pathway involved in heart development is_a: GO:0060070 ! canonical Wnt signaling pathway intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-24T09:25:03Z [Term] id: GO:0061317 name: canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart, PMID:17576928] synonym: "canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] synonym: "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0060923 ! cardiac muscle cell fate commitment relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment created_by: dph creation_date: 2010-09-24T09:29:21Z [Term] id: GO:0061318 name: renal filtration cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0072001 ! renal system development created_by: dph creation_date: 2010-09-24T12:18:35Z [Term] id: GO:0061319 name: nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0061318 ! renal filtration cell differentiation created_by: dph creation_date: 2010-09-24T12:23:29Z [Term] id: GO:0061320 name: pericardial nephrocyte differentiation namespace: biological_process alt_id: GO:0007513 def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] synonym: "pericardial cell differentiation" NARROW [] is_a: GO:0061319 ! nephrocyte differentiation created_by: dph creation_date: 2010-09-24T12:25:53Z [Term] id: GO:0061321 name: garland nephrocyte differentiation namespace: biological_process alt_id: GO:0007514 def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] synonym: "garland cell differentiation" EXACT [] is_a: GO:0061319 ! nephrocyte differentiation relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm created_by: dph creation_date: 2010-09-24T12:28:16Z [Term] id: GO:0061322 name: disseminated nephrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0061319 ! nephrocyte differentiation created_by: dph creation_date: 2010-09-24T12:30:46Z [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-28T09:05:26Z [Term] id: GO:0061324 name: canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation namespace: biological_process def: "The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells." [GOC:dph, GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:signaling] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis created_by: dph creation_date: 2010-09-28T09:19:37Z [Term] id: GO:0061325 name: cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2010-09-28T09:29:30Z [Term] id: GO:0061326 name: renal tubule development namespace: biological_process def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0072001 ! renal system development created_by: dph creation_date: 2010-09-28T12:50:43Z [Term] id: GO:0061327 name: anterior Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0072002 ! Malpighian tubule development created_by: dph creation_date: 2010-09-28T01:23:18Z [Term] id: GO:0061328 name: posterior Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0072002 ! Malpighian tubule development created_by: dph creation_date: 2010-09-28T01:24:35Z [Term] id: GO:0061329 name: Malpighian tubule principal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development created_by: dph creation_date: 2010-09-28T01:26:33Z [Term] id: GO:0061330 name: Malpighian tubule stellate cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development created_by: dph creation_date: 2010-09-28T01:32:55Z [Term] id: GO:0061331 name: epithelial cell proliferation involved in Malpighian tubule morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-09-28T02:01:02Z [Term] id: GO:0061332 name: Malpighian tubule bud morphogenesis namespace: biological_process def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] synonym: "Malpighian tubule formation" EXACT [GOC:dph] is_a: GO:0060572 ! morphogenesis of an epithelial bud is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-09-28T01:39:32Z [Term] id: GO:0061333 name: renal tubule morphogenesis namespace: biological_process def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0061326 ! renal tubule development created_by: dph creation_date: 2010-09-28T01:43:04Z [Term] id: GO:0061334 name: cell rearrangement involved in Malpighian tubule morphogenesis namespace: biological_process def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10] synonym: "cell migration involved in Malpighian tubule morphogenesis" EXACT [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-09-28T02:04:05Z [Term] id: GO:0061335 name: cell growth involved in Malpighian tubule morphogenesis namespace: biological_process def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0048588 ! developmental cell growth intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-09-28T02:08:25Z [Term] id: GO:0061336 name: cell morphogenesis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-09-28T02:11:47Z [Term] id: GO:0061337 name: cardiac conduction namespace: biological_process def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0035637 ! multicellular organismal signaling created_by: dph creation_date: 2010-09-29T08:46:05Z [Term] id: GO:0061338 name: obsolete atrioventricular node impulse conduction delay namespace: biological_process def: "OBSOLETE. A heart process that modulates the propagation of the signal that causes the heart muscle to contract." [GOC:dph] comment: This term was made obsolete because it was created before the cardiac conduction overhaul, and represents a measurement rather than a process. synonym: "atrioventricular node impulse conduction delay" EXACT [] is_obsolete: true consider: GO:0086016 created_by: dph creation_date: 2010-09-29T08:55:53Z [Term] id: GO:0061339 name: establishment or maintenance of monopolar cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] is_a: GO:0007163 ! establishment or maintenance of cell polarity created_by: dph creation_date: 2010-09-29T09:10:05Z [Term] id: GO:0061340 name: establishment or maintenance of monopolar cell polarity regulating cell shape namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:dph, GOC:vw] is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: dph creation_date: 2010-09-29T09:13:55Z [Term] id: GO:0061341 name: non-canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783] synonym: "non-canonical Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "non-canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003306 ! Wnt signaling pathway involved in heart development is_a: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-09-29T11:27:34Z [Term] id: GO:0061342 name: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart." [PMID:16860783] synonym: "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway" EXACT [GOC:mah] is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development is_a: GO:0061344 ! regulation of cell adhesion involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T11:30:15Z [Term] id: GO:0061343 name: cell adhesion involved in heart morphogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-29T11:34:06Z [Term] id: GO:0061344 name: regulation of cell adhesion involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T11:35:27Z [Term] id: GO:0061345 name: planar cell polarity pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development created_by: dph creation_date: 2010-09-30T12:39:05Z [Term] id: GO:0061346 name: planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2010-09-30T12:47:24Z [Term] id: GO:0061347 name: planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2010-10-01T10:38:56Z [Term] id: GO:0061348 name: planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis created_by: dph creation_date: 2010-10-01T10:47:49Z [Term] id: GO:0061349 name: planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis created_by: dph creation_date: 2010-10-01T10:52:01Z [Term] id: GO:0061350 name: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis created_by: dph creation_date: 2010-10-01T10:57:33Z [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] is_a: GO:0008283 ! cell population proliferation created_by: dph creation_date: 2010-10-01T11:06:04Z [Term] id: GO:0061352 name: cell chemotaxis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0060326 ! cell chemotaxis is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis intersection_of: GO:0060326 ! cell chemotaxis intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph creation_date: 2010-10-01T11:57:28Z [Term] id: GO:0061353 name: BMP signaling pathway involved in Malpighian tubule cell chemotaxis namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] synonym: "bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis relationship: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis created_by: dph creation_date: 2010-10-01T12:01:00Z [Term] id: GO:0061354 name: planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium." [GOC:dph, GOC:mtg_heart, PMID:19056682] is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: part_of GO:0003344 ! pericardium morphogenesis created_by: dph creation_date: 2010-10-01T03:12:53Z [Term] id: GO:0061355 name: Wnt protein secretion namespace: biological_process def: "The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] is_a: GO:0009306 ! protein secretion is_a: GO:0023061 ! signal release relationship: part_of GO:0198738 ! cell-cell signaling by wnt created_by: dph creation_date: 2010-10-08T01:07:48Z [Term] id: GO:0061356 name: regulation of Wnt protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061355 ! Wnt protein secretion relationship: regulates GO:0061355 ! Wnt protein secretion created_by: dph creation_date: 2010-10-08T01:09:51Z [Term] id: GO:0061357 name: positive regulation of Wnt protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0061356 ! regulation of Wnt protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061355 ! Wnt protein secretion relationship: positively_regulates GO:0061355 ! Wnt protein secretion created_by: dph creation_date: 2010-10-08T01:12:21Z [Term] id: GO:0061358 name: negative regulation of Wnt protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0061356 ! regulation of Wnt protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061355 ! Wnt protein secretion relationship: negatively_regulates GO:0061355 ! Wnt protein secretion created_by: dph creation_date: 2010-10-08T01:15:15Z [Term] id: GO:0061359 name: regulation of Wnt signaling pathway by Wnt protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell." [GOC:bf, GOC:jl, PMID:19223472] synonym: "regulation of Wnt receptor signaling pathway by Wnt protein secretion" EXACT [] synonym: "regulation of Wnt receptor signalling pathway by Wnt protein secretion" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway by Wnt protein secretion" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:0061355 ! Wnt protein secretion intersection_of: GO:0061355 ! Wnt protein secretion intersection_of: regulates GO:0016055 ! Wnt signaling pathway created_by: dph creation_date: 2010-10-08T01:18:02Z [Term] id: GO:0061360 name: optic chiasma development namespace: biological_process def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph] synonym: "optic chiasm development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021554 ! optic nerve development created_by: dph creation_date: 2010-10-13T08:00:29Z [Term] id: GO:0061361 name: positive regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape relationship: positively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-10-13T09:00:59Z [Term] id: GO:0061362 name: negative regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape is_a: GO:2000750 ! negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape relationship: negatively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-10-13T09:03:42Z [Term] id: GO:0061363 name: negative regulation of progesterone biosynthesis involved in luteolysis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis." [GOC:dph] synonym: "functional luteolysis" EXACT [GOC:dph] is_a: GO:0022602 ! ovulation cycle process is_a: GO:2000183 ! negative regulation of progesterone biosynthetic process intersection_of: GO:2000183 ! negative regulation of progesterone biosynthetic process intersection_of: part_of GO:0001554 ! luteolysis relationship: part_of GO:0001554 ! luteolysis created_by: dph creation_date: 2010-10-14T03:08:41Z [Term] id: GO:0061364 name: apoptotic process involved in luteolysis namespace: biological_process def: "The apoptotic process that contributes to luteolysis." [GOC:mtg_apoptosis, PMID:18566128] synonym: "apoptosis involved in luteolysis" NARROW [] synonym: "structural luteolysis" EXACT [GOC:dph] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0001554 ! luteolysis relationship: part_of GO:0001554 ! luteolysis created_by: dph creation_date: 2010-10-14T03:18:49Z [Term] id: GO:0061365 name: positive regulation of triglyceride lipase activity namespace: biological_process def: "Any process that increases the activity of triglyceride lipase." [GOC:dph] synonym: "positive regulation of TAG activity" EXACT [PMID:16054079] is_a: GO:0060193 ! positive regulation of lipase activity intersection_of: GO:0065009 ! regulation of molecular function intersection_of: positively_regulates GO:0004806 ! triglyceride lipase activity relationship: positively_regulates GO:0004806 ! triglyceride lipase activity created_by: dph creation_date: 2010-10-15T08:27:22Z [Term] id: GO:0061366 name: behavioral response to chemical pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus." [GOC:dph] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0048266 ! behavioral response to pain created_by: dph creation_date: 2010-10-21T03:25:01Z [Term] id: GO:0061367 name: behavioral response to acetic acid induced pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus." [GOC:dph] is_a: GO:0061366 ! behavioral response to chemical pain created_by: dph creation_date: 2010-10-21T03:26:31Z [Term] id: GO:0061368 name: behavioral response to formalin induced pain namespace: biological_process def: "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus." [GOC:dph] is_a: GO:0061366 ! behavioral response to chemical pain created_by: dph creation_date: 2010-10-21T03:29:48Z [Term] id: GO:0061369 name: negative regulation of testicular blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle." [GOC:BHF, GOC:dph] synonym: "negative regulation of testicular vasculature morphogenesis" BROAD [GOC:BHF, GOC:dph] is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis created_by: dph creation_date: 2010-10-27T02:47:14Z [Term] id: GO:0061370 name: testosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: dph creation_date: 2010-10-27T02:50:48Z [Term] id: GO:0061371 name: determination of heart left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart] synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2010-11-03T02:13:58Z [Term] id: GO:0061372 name: activin receptor signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "activin receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0032924 ! activin receptor signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0032924 ! activin receptor signaling pathway intersection_of: part_of GO:0003146 ! heart jogging relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2010-11-03T02:24:46Z [Term] id: GO:0061373 name: mammillary axonal complex development namespace: biological_process def: "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain." [GOC:dph, GOC:yaf, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021767 ! mammillary body development created_by: dph creation_date: 2010-11-09T08:49:59Z [Term] id: GO:0061374 name: mammillothalamic axonal tract development namespace: biological_process def: "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit." [GOC:dph, GOC:yaf, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development created_by: dph creation_date: 2010-11-09T08:54:43Z [Term] id: GO:0061375 name: mammillotectal axonal tract development namespace: biological_process def: "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus." [GOC:dph, GOC:yaf, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development created_by: dph creation_date: 2010-11-09T09:01:14Z [Term] id: GO:0061376 name: mammillotegmental axonal tract development namespace: biological_process def: "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons." [GOC:dph, GOC:yaf, PMID:10662642] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061373 ! mammillary axonal complex development created_by: dph creation_date: 2010-11-09T09:09:29Z [Term] id: GO:0061377 name: mammary gland lobule development namespace: biological_process def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030879 ! mammary gland development created_by: dph creation_date: 2010-11-09T09:36:29Z [Term] id: GO:0061378 name: corpora quadrigemina development namespace: biological_process def: "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030901 ! midbrain development created_by: dph creation_date: 2010-11-09T09:45:36Z [Term] id: GO:0061379 name: inferior colliculus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061378 ! corpora quadrigemina development created_by: dph creation_date: 2010-11-09T09:49:24Z [Term] id: GO:0061380 name: superior colliculus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061378 ! corpora quadrigemina development created_by: dph creation_date: 2010-11-09T09:51:00Z [Term] id: GO:0061381 name: cell migration in diencephalon namespace: biological_process def: "The orderly movement of a cell that will reside in the diencephalon." [GOC:dph] is_a: GO:0021885 ! forebrain cell migration relationship: part_of GO:0021536 ! diencephalon development created_by: dph creation_date: 2010-11-09T09:54:27Z [Term] id: GO:0061382 name: Malpighian tubule tip cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0072002 ! Malpighian tubule development created_by: dph creation_date: 2010-11-23T09:52:44Z [Term] id: GO:0061383 name: trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: dph creation_date: 2010-12-02T08:51:45Z [Term] id: GO:0061384 name: heart trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] is_a: GO:0061383 ! trabecula morphogenesis created_by: dph creation_date: 2010-12-02T08:54:20Z [Term] id: GO:0061385 name: fibroblast proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] is_a: GO:0048144 ! fibroblast proliferation is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0048144 ! fibroblast proliferation intersection_of: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2011-02-10T01:41:59Z [Term] id: GO:0061386 name: closure of optic fissure namespace: biological_process def: "The closure of the temporary ventral gap in the optic cup that contributes to its shaping." [GOC:dph] synonym: "closure or choriod fissure" RELATED [GOC:dph] is_a: GO:0002011 ! morphogenesis of an epithelial sheet relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development created_by: dph creation_date: 2011-03-30T08:14:59Z [Term] id: GO:0061387 name: regulation of extent of cell growth namespace: biological_process def: "Any process that modulates the extent of cell growth." [GOC:mah, GOC:vw] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0008361 ! regulation of cell size created_by: dph creation_date: 2011-07-14T10:15:42Z [Term] id: GO:0061388 name: regulation of rate of cell growth namespace: biological_process def: "Any process that modulates the rate of cell growth." [GOC:mah, GOC:vw] is_a: GO:0001558 ! regulation of cell growth created_by: dph creation_date: 2011-07-14T10:18:06Z [Term] id: GO:0061389 name: regulation of direction of cell growth namespace: biological_process def: "Any process that modulates the direction of cell growth." [GOC:mah, GOC:vw] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0008360 ! regulation of cell shape created_by: dph creation_date: 2011-07-14T10:19:46Z [Term] id: GO:0061390 name: positive regulation of direction of cell growth namespace: biological_process def: "Any process that increases the direction of cell growth." [GOC:mah, GOC:vw] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0061389 ! regulation of direction of cell growth created_by: dph creation_date: 2011-07-14T10:22:55Z [Term] id: GO:0061391 name: negative regulation of direction of cell growth namespace: biological_process def: "Any process that decreases the direction of cell growth." [GOC:mah, GOC:vw] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0061389 ! regulation of direction of cell growth created_by: dph creation_date: 2011-07-14T10:25:55Z [Term] id: GO:0061392 name: regulation of transcription from RNA polymerase II promoter in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0071470 ! cellular response to osmotic stress created_by: dph creation_date: 2011-12-13T08:52:04Z [Term] id: GO:0061393 name: positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress created_by: dph creation_date: 2011-12-13T08:58:20Z [Term] id: GO:0061394 name: regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph] is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress relationship: part_of GO:0071243 ! cellular response to arsenic-containing substance created_by: dph creation_date: 2011-12-14T08:48:36Z [Term] id: GO:0061395 name: positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0061394 ! regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus created_by: dph creation_date: 2011-12-14T08:53:20Z [Term] id: GO:0061396 name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2012-01-10T09:07:08Z [Term] id: GO:0061397 name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to copper ion namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2012-01-10T09:14:51Z [Term] id: GO:0061398 name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to copper ion namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2012-01-10T09:17:02Z [Term] id: GO:0061399 name: positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus." [GOC:dph] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0071279 ! cellular response to cobalt ion created_by: dph creation_date: 2012-01-10T09:28:52Z [Term] id: GO:0061400 name: positive regulation of transcription from RNA polymerase II promoter in response to calcium ion namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus." [GOC:dph] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0071277 ! cellular response to calcium ion created_by: dph creation_date: 2012-01-10T09:36:02Z [Term] id: GO:0061401 name: positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress is_a: GO:0071476 ! cellular hypotonic response created_by: dph creation_date: 2012-01-10T09:43:08Z [Term] id: GO:0061402 name: positive regulation of transcription from RNA polymerase II promoter in response to acidic pH namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7." [GOC:dph, GOC:go_curators] synonym: "positive regulation of transcription from RNA polymerase II promoter in response to acidity" BROAD [] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0071468 ! cellular response to acidic pH created_by: dph creation_date: 2012-01-10T03:06:32Z [Term] id: GO:0061403 name: positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0071500 ! cellular response to nitrosative stress created_by: dph creation_date: 2012-01-10T03:15:30Z [Term] id: GO:0061404 name: positive regulation of transcription from RNA polymerase II promoter in response to increased salt namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] is_a: GO:0036251 ! positive regulation of transcription from RNA polymerase II promoter in response to salt stress is_a: GO:0071475 ! cellular hyperosmotic salinity response created_by: dph creation_date: 2012-01-10T03:20:40Z [Term] id: GO:0061405 name: positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0071464 ! cellular response to hydrostatic pressure created_by: dph creation_date: 2012-01-10T03:24:51Z [Term] id: GO:0061406 name: positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0042149 ! cellular response to glucose starvation created_by: dph creation_date: 2012-01-12T11:16:10Z [Term] id: GO:0061407 name: positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:dph] is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide created_by: dph creation_date: 2012-01-12T11:39:10Z [Term] id: GO:0061408 name: positive regulation of transcription from RNA polymerase II promoter in response to heat stress namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph] is_a: GO:0034605 ! cellular response to heat is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress created_by: dph creation_date: 2012-01-12T11:50:30Z [Term] id: GO:0061409 name: positive regulation of transcription from RNA polymerase II promoter in response to freezing namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:dph] is_a: GO:0061411 ! positive regulation of transcription from RNA polymerase II promoter in response to cold is_a: GO:0071497 ! cellular response to freezing created_by: dph creation_date: 2012-01-12T12:11:06Z [Term] id: GO:0061410 name: positive regulation of transcription from RNA polymerase II promoter in response to ethanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus." [GOC:dph] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0071361 ! cellular response to ethanol created_by: dph creation_date: 2012-01-12T12:17:35Z [Term] id: GO:0061411 name: positive regulation of transcription from RNA polymerase II promoter in response to cold namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0070417 ! cellular response to cold created_by: dph creation_date: 2012-01-12T12:31:33Z [Term] id: GO:0061412 name: positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids." [GOC:dph] is_a: GO:0034198 ! cellular response to amino acid starvation is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress created_by: dph creation_date: 2012-01-12T12:54:05Z [Term] id: GO:0061413 name: regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source namespace: biological_process def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter created_by: dph creation_date: 2012-01-23T11:13:06Z [Term] id: GO:0061414 name: positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source namespace: biological_process def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source created_by: dph creation_date: 2012-01-23T11:31:27Z [Term] id: GO:0061415 name: negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source namespace: biological_process def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source created_by: dph creation_date: 2012-01-23T11:33:08Z [Term] id: GO:0061416 name: regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581] is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress is_a: GO:0071472 ! cellular response to salt stress created_by: dph creation_date: 2012-01-23T12:56:36Z [Term] id: GO:0061417 name: negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:dph, PMID:9767597] is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress created_by: dph creation_date: 2012-01-23T01:02:10Z [Term] id: GO:0061418 name: regulation of transcription from RNA polymerase II promoter in response to hypoxia namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:12511571] is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress relationship: part_of GO:0071456 ! cellular response to hypoxia created_by: dph creation_date: 2012-01-23T01:05:59Z [Term] id: GO:0061419 name: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus created_by: dph creation_date: 2012-01-23T01:07:43Z [Term] id: GO:0061420 name: regulation of transcription from RNA polymerase II promoter in response to biotin starvation namespace: biological_process def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin." [GOC:dph, PMID:16533810] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress created_by: dph creation_date: 2012-01-25T09:55:39Z [Term] id: GO:0061421 name: positive regulation of transcription by oleic acid namespace: biological_process def: "Any process involving oleic acid that activates or increases the rate of transcription." [GOC:dph, PMID:20395639] is_a: GO:0045991 ! carbon catabolite activation of transcription created_by: dph creation_date: 2012-01-25T10:11:39Z [Term] id: GO:0061422 name: positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0." [GOC:dph, PMID:11523797, PMID:15299026, PMID:21749328] synonym: "positive regulation of transcription from RNA polymerase II promoter in response to alkalinity" BROAD [] is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress is_a: GO:0071469 ! cellular response to alkaline pH created_by: dph creation_date: 2012-01-26T12:42:21Z [Term] id: GO:0061423 name: positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, PMID:11523797] is_a: GO:0010765 ! positive regulation of sodium ion transport is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006814 ! sodium ion transport created_by: dph creation_date: 2012-01-26T12:52:05Z [Term] id: GO:0061424 name: obsolete positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization." [GOC:dph, PMID:7500953] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "positive regulation of peroxisome organisation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:mah] is_obsolete: true created_by: dph creation_date: 2012-02-02T12:50:36Z [Term] id: GO:0061425 name: positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process." [GOC:dph, PMID:10608811, PMID:7760841] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1900066 ! positive regulation of ethanol catabolic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006068 ! ethanol catabolic process created_by: dph creation_date: 2012-02-02T01:12:36Z [Term] id: GO:0061426 name: positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport." [GOC:dph, PMID:10234785, PMID:10870099] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1900072 ! positive regulation of sulfite transport intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0000316 ! sulfite transport created_by: dph creation_date: 2012-02-02T01:21:46Z [Term] id: GO:0061427 name: negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph, PMID:15302821] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0046513 ! ceramide biosynthetic process created_by: dph creation_date: 2012-02-02T01:30:41Z [Term] id: GO:0061428 name: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:17785431] is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress created_by: dph creation_date: 2012-02-06T09:26:05Z [Term] id: GO:0061429 name: positive regulation of transcription from RNA polymerase II promoter by oleic acid namespace: biological_process def: "Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dph, PMID:20395639] is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0061421 ! positive regulation of transcription by oleic acid created_by: dph creation_date: 2012-02-07T09:54:49Z [Term] id: GO:0061430 name: bone trabecula morphogenesis namespace: biological_process def: "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:BHF, GOC:dph, GOC:vk] is_a: GO:0061383 ! trabecula morphogenesis created_by: dph creation_date: 2012-02-07T10:15:36Z [Term] id: GO:0061431 name: cellular response to methionine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GOC:dph, PMID:7891681] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1904640 ! response to methionine created_by: dph creation_date: 2012-02-07T10:27:01Z [Term] id: GO:0061432 name: obsolete regulation of transcription from RNA polymerase II promoter in response to methionine namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus." [GOC:dph, PMID:7891681] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2012-02-07T10:33:35Z [Term] id: GO:0061433 name: cellular response to caloric restriction namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." [GOC:dph, PMID:17914901] is_a: GO:0033554 ! cellular response to stress is_a: GO:0061771 ! response to caloric restriction created_by: dph creation_date: 2012-02-09T09:03:15Z [Term] id: GO:0061434 name: obsolete regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus." [GOC:dph, PMID:17914901] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2012-02-09T09:06:09Z [Term] id: GO:0061435 name: positive regulation of transcription from a mobile element promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter." [GOC:dph, PMID:12230120, PMID:9271107] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated created_by: dph creation_date: 2012-02-09T10:01:33Z [Term] id: GO:0061436 name: establishment of skin barrier namespace: biological_process def: "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability." [GOC:dph] synonym: "epithelial barrier development" RELATED [GOC:dph] synonym: "establishment of epithelial barrier" BROAD [GOC:dph] synonym: "skin barrier development" RELATED [GOC:dph] is_a: GO:0033561 ! regulation of water loss via skin relationship: part_of GO:0043588 ! skin development created_by: dph creation_date: 2012-03-02T09:14:26Z [Term] id: GO:0061437 name: renal system vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0001944 ! vasculature development relationship: part_of GO:0072001 ! renal system development created_by: dph creation_date: 2012-03-08T12:16:24Z [Term] id: GO:0061438 name: renal system vasculature morphogenesis namespace: biological_process def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0061437 ! renal system vasculature development created_by: dph creation_date: 2012-03-08T12:21:56Z [Term] id: GO:0061439 name: kidney vasculature morphogenesis namespace: biological_process def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0061438 ! renal system vasculature morphogenesis relationship: part_of GO:0061440 ! kidney vasculature development created_by: dph creation_date: 2012-03-08T12:30:11Z [Term] id: GO:0061440 name: kidney vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0061437 ! renal system vasculature development relationship: part_of GO:0001822 ! kidney development created_by: dph creation_date: 2012-03-08T12:39:09Z [Term] id: GO:0061441 name: renal artery morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195] is_a: GO:0048844 ! artery morphogenesis relationship: part_of GO:0061439 ! kidney vasculature morphogenesis created_by: dph creation_date: 2012-03-08T12:42:09Z [Term] id: GO:0061442 name: cardiac muscle cell fate determination namespace: biological_process def: "The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph] is_a: GO:0007521 ! muscle cell fate determination is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment created_by: dph creation_date: 2012-03-13T08:59:57Z [Term] id: GO:0061443 name: endocardial cushion cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:dph] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003197 ! endocardial cushion development created_by: dph creation_date: 2012-03-13T09:05:38Z [Term] id: GO:0061444 name: endocardial cushion cell development namespace: biological_process def: "The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state." [GOC:BHF, GOC:dph] is_a: GO:0055006 ! cardiac cell development relationship: part_of GO:0061443 ! endocardial cushion cell differentiation created_by: dph creation_date: 2012-03-13T09:07:46Z [Term] id: GO:0061445 name: endocardial cushion cell fate commitment namespace: biological_process def: "The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell." [GOC:BHF, GOC:dph] is_a: GO:0060957 ! endocardial cell fate commitment relationship: part_of GO:0061443 ! endocardial cushion cell differentiation created_by: dph creation_date: 2012-03-13T09:11:03Z [Term] id: GO:0061446 name: endocardial cushion cell fate determination namespace: biological_process def: "The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph] is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment created_by: dph creation_date: 2012-03-13T09:22:13Z [Term] id: GO:0061447 name: endocardial cushion cell fate specification namespace: biological_process def: "The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:BHF, GOC:dph] is_a: GO:0060912 ! cardiac cell fate specification relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment created_by: dph creation_date: 2012-03-13T09:25:56Z [Term] id: GO:0061448 name: connective tissue development namespace: biological_process def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] is_a: GO:0009888 ! tissue development created_by: dph creation_date: 2012-03-22T12:53:41Z [Term] id: GO:0061449 name: olfactory bulb tufted cell development namespace: biological_process def: "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021772 ! olfactory bulb development created_by: dph creation_date: 2012-05-15T12:30:21Z [Term] id: GO:0061450 name: trophoblast cell migration namespace: biological_process def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph] is_a: GO:0001667 ! ameboidal-type cell migration is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007566 ! embryo implantation created_by: dph creation_date: 2012-07-10T08:38:37Z [Term] id: GO:0061451 name: retrotrapezoid nucleus development namespace: biological_process def: "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration." [GOC:dph] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development created_by: dph creation_date: 2012-07-19T12:38:30Z [Term] id: GO:0061452 name: retrotrapezoid nucleus neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus." [GOC:dph] is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0061451 ! retrotrapezoid nucleus development created_by: dph creation_date: 2012-07-19T12:43:18Z [Term] id: GO:0061453 name: interstitial cell of Cajal differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph] synonym: "ICC differentiation" RELATED [GOC:dph] is_a: GO:0060563 ! neuroepithelial cell differentiation is_a: GO:0060575 ! intestinal epithelial cell differentiation created_by: dph creation_date: 2012-07-20T08:20:50Z [Term] id: GO:0061454 name: release of sequestered calcium ion into cytosol by Golgi namespace: biological_process def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb] synonym: "Golgi calcium ion export" BROAD [] is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0061856 ! Golgi calcium ion transmembrane transport created_by: dph creation_date: 2012-07-27T02:29:43Z [Term] id: GO:0061455 name: integral component of muscle cell projection membrane namespace: cellular_component def: "The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:dph, GOC:tb] synonym: "integral to muscle cell projection membrane" EXACT [] is_a: GO:0005887 ! integral component of plasma membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0036195 ! muscle cell projection membrane relationship: part_of GO:0036195 ! muscle cell projection membrane created_by: dph creation_date: 2012-07-27T02:38:01Z [Term] id: GO:0061456 name: mesenchymal stem cell migration involved in uteric bud morphogenesis namespace: biological_process def: "The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:dph, GOC:tb] is_a: GO:0035787 ! cell migration involved in kidney development relationship: part_of GO:0060675 ! ureteric bud morphogenesis created_by: dph creation_date: 2012-08-22T17:19:22Z [Term] id: GO:0061457 name: mesonephric cell migration involved in male gonad development namespace: biological_process def: "The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development." [GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration created_by: dph creation_date: 2012-08-22T17:31:00Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development created_by: dph creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061459 name: L-arginine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015598 alt_id: GO:0102022 def: "Enables the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:dph] synonym: "arginine porter activity" NARROW [] synonym: "arginine-importing ATPase activity" NARROW [] synonym: "ATP-dependent L-arginine transmembrane transporter activity" NARROW [] synonym: "ATPase-coupled L-arginine transmembrane transporter activity" NARROW [] synonym: "L-arginine-importing ATPase activity" NARROW [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity relationship: part_of GO:1903400 ! L-arginine transmembrane transport created_by: dph creation_date: 2012-09-25T08:37:29Z [Term] id: GO:0061462 name: protein localization to lysosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph] is_a: GO:0072665 ! protein localization to vacuole created_by: dph creation_date: 2012-10-05T10:50:51Z [Term] id: GO:0061463 name: O-acetyl-ADP-ribose deacetylase activity namespace: molecular_function def: "Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate." [GOC:dph] is_a: GO:0019213 ! deacetylase activity created_by: dph creation_date: 2012-10-05T11:05:06Z [Term] id: GO:0061464 name: obsolete plasma membrane part of cell-substrate junction namespace: cellular_component def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell-substrate junction." [GOC:dph] comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. is_obsolete: true created_by: dph creation_date: 2012-10-19T11:04:48Z [Term] id: GO:0061465 name: obsolete plasma membrane part of hemidesmosome namespace: cellular_component def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a hemidesmosome." [GOC:dph] comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. is_obsolete: true created_by: dph creation_date: 2012-10-19T13:47:25Z [Term] id: GO:0061466 name: obsolete plasma membrane part of cell junction namespace: cellular_component def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell junction." [GOC:dph] comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. is_obsolete: true created_by: dph creation_date: 2012-10-19T13:53:44Z [Term] id: GO:0061468 name: karyomere namespace: cellular_component def: "A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division." [GOC:dph, PMID:12734396, PMID:22863006] is_a: GO:0043231 ! intracellular membrane-bounded organelle created_by: dph creation_date: 2012-10-22T14:19:29Z [Term] id: GO:0061469 name: regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044342 ! type B pancreatic cell proliferation relationship: regulates GO:0044342 ! type B pancreatic cell proliferation created_by: dph creation_date: 2012-11-01T13:16:23Z [Term] id: GO:0061470 name: T follicular helper cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell." [GOC:dph, PMID:21572431] synonym: "T-helper follicular cell differentiation" EXACT [GOC:dph] is_a: GO:0042093 ! T-helper cell differentiation created_by: dph creation_date: 2012-11-02T09:01:48Z [Term] id: GO:0061471 name: karyomere assembly namespace: biological_process def: "The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle." [GOC:dph, PMID:9732278] is_a: GO:0070925 ! organelle assembly is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly created_by: dph creation_date: 2012-11-02T09:13:59Z [Term] id: GO:0061472 name: karyomere membrane fusion namespace: biological_process def: "Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus." [GOC:dph, PMID:2734396] is_a: GO:0090174 ! organelle membrane fusion is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly created_by: dph creation_date: 2012-11-02T09:25:41Z [Term] id: GO:0061473 name: murein tripeptide carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate." [GOC:dph, PMID:22970852] is_a: GO:0004181 ! metallocarboxypeptidase activity created_by: dph creation_date: 2012-11-06T12:23:39Z [Term] id: GO:0061474 name: phagolysosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a phagolysosome." [GOC:dph, PMID:22073313] is_a: GO:0005765 ! lysosomal membrane is_a: GO:0030670 ! phagocytic vesicle membrane relationship: part_of GO:0032010 ! phagolysosome created_by: dph creation_date: 2012-11-06T12:26:18Z [Term] id: GO:0061475 name: cytosolic valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:dph] is_a: GO:0006438 ! valyl-tRNA aminoacylation intersection_of: GO:0006438 ! valyl-tRNA aminoacylation intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol created_by: dph creation_date: 2012-11-06T12:29:42Z [Term] id: GO:0061476 name: response to anticoagulant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus." [GOC:dph] is_a: GO:0042493 ! response to drug created_by: dph creation_date: 2012-11-07T09:07:00Z [Term] id: GO:0061477 name: response to aromatase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus." [GOC:dph] is_a: GO:0042221 ! response to chemical created_by: dph creation_date: 2012-11-07T09:08:36Z [Term] id: GO:0061478 name: response to platelet aggregation inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus." [GOC:dph] is_a: GO:0042493 ! response to drug created_by: dph creation_date: 2012-11-07T09:09:37Z [Term] id: GO:0061479 name: response to reverse transcriptase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus." [GOC:dph] is_a: GO:0046677 ! response to antibiotic created_by: dph creation_date: 2012-11-07T09:10:51Z [Term] id: GO:0061480 name: response to asparaginase namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus." [GOC:dph] is_a: GO:0042221 ! response to chemical created_by: dph creation_date: 2012-11-07T09:13:08Z [Term] id: GO:0061481 name: response to TNF agonist namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus." [GOC:dph] is_a: GO:0042221 ! response to chemical created_by: dph creation_date: 2012-11-07T09:14:07Z [Term] id: GO:0061482 name: response to irinotecan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus." [GOC:dph] is_a: GO:0042221 ! response to chemical created_by: dph creation_date: 2012-11-07T09:15:03Z [Term] id: GO:0061483 name: sulfinylpropanyl adenylate synthase namespace: molecular_function def: "Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate." [GOC:dph, PMID:8346915] synonym: "SPA synthase" RELATED [PMID:8346915] is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds created_by: dph creation_date: 2012-11-16T10:08:15Z [Term] id: GO:0061484 name: hematopoietic stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411] is_a: GO:0048872 ! homeostasis of number of cells created_by: dph creation_date: 2012-12-04T09:41:02Z [Term] id: GO:0061485 name: memory T cell proliferation namespace: biological_process def: "The expansion of a memory T cell population by cell division." [GOC:dph, PMID:14647273] is_a: GO:0042098 ! T cell proliferation created_by: dph creation_date: 2012-12-04T09:52:54Z [Term] id: GO:0061486 name: high-affinity fructose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:dph, PMID:10735857] synonym: "high affinity fructose transmembrane transporter activity" EXACT [] is_a: GO:0005353 ! fructose transmembrane transporter activity created_by: dph creation_date: 2012-12-04T10:34:55Z [Term] id: GO:0061487 name: obsolete DNA replication initiation from late origin namespace: biological_process def: "OBSOLETE. The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase." [GOC:dph, PMID:19221029] comment: The reason for obsoletion is that there is no evidence that this is a different process from its parent term (DNA replication initiation, GO:0006270), but only that regulation of initiation at late origins differs from regulation of initiation at early origins. synonym: "late replication origin firing" EXACT [GOC:dph, PMID:19221029] is_obsolete: true consider: GO:0101017 created_by: dph creation_date: 2012-12-06T11:21:48Z [Term] id: GO:0061492 name: asymmetric protein localization to old or new spindle pole body namespace: biological_process def: "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, PMID:22119525] is_a: GO:0071988 ! protein localization to spindle pole body created_by: dph creation_date: 2012-12-06T15:23:15Z [Term] id: GO:0061493 name: central plaque of mitotic spindle pole body namespace: cellular_component def: "One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope." [GOC:dph] is_a: GO:0005823 ! central plaque of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:08:26Z [Term] id: GO:0061494 name: gamma-tubulin large complex, mitotic spindle pole body namespace: cellular_component def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the mitotic spindle pole body." [GOC:dph] is_a: GO:0055032 ! gamma-tubulin large complex, spindle pole body intersection_of: GO:0000931 ! gamma-tubulin large complex intersection_of: part_of GO:0044732 ! mitotic spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:10:00Z [Term] id: GO:0061495 name: gamma-tubulin small complex, mitotic spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the mitotic spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:dph] is_a: GO:0000928 ! gamma-tubulin small complex, spindle pole body intersection_of: GO:0008275 ! gamma-tubulin small complex intersection_of: part_of GO:0044732 ! mitotic spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:11:27Z [Term] id: GO:0061496 name: half bridge of mitotic spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the mitotic spindle pole body." [GOC:dph] is_a: GO:0005825 ! half bridge of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:13:52Z [Term] id: GO:0061497 name: inner plaque of mitotic spindle pole body namespace: cellular_component def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus." [GOC:dph, GOC:vw] is_a: GO:0005822 ! inner plaque of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:15:12Z [Term] id: GO:0061498 name: intermediate layer of mitotic spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the mitotic spindle pole body." [GOC:dph] is_a: GO:0005821 ! intermediate layer of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:17:14Z [Term] id: GO:0061499 name: outer plaque of mitotic spindle pole body namespace: cellular_component def: "One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm." [GOC:dph] is_a: GO:0005824 ! outer plaque of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph creation_date: 2012-12-11T09:18:43Z [Term] id: GO:0061500 name: gene conversion at mating-type locus, termination of copy-synthesis namespace: biological_process def: "A DNA replication termination process that is part of gene conversion at a mating-type locus and takes place at a specific termination site." [GOC:dph, PMID:10716938] is_a: GO:0022414 ! reproductive process is_a: GO:0071170 ! site-specific DNA replication termination intersection_of: GO:0071170 ! site-specific DNA replication termination intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus relationship: part_of GO:0007534 ! gene conversion at mating-type locus created_by: dph creation_date: 2012-12-11T09:32:31Z [Term] id: GO:0061501 name: cyclic-GMP-AMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [GOC:dph, PMID:23258413] xref: Reactome:R-HSA-3244614 "cGAS produces cyclic GMP-AMP" is_a: GO:0016779 ! nucleotidyltransferase activity created_by: dph creation_date: 2013-01-04T07:17:57Z [Term] id: GO:0061502 name: early endosome to recycling endosome transport namespace: biological_process def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes." [GOC:dph, GOC:kmv, PMID:21474295] is_a: GO:0016482 ! cytosolic transport is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments created_by: dph creation_date: 2013-01-04T07:24:56Z [Term] id: GO:0061503 name: tRNA threonylcarbamoyladenosine dehydratase namespace: molecular_function def: "Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A." [GOC:dph, PMID:23242255] is_a: GO:0016836 ! hydro-lyase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: dph creation_date: 2013-01-22T14:22:14Z [Term] id: GO:0061504 name: cyclic threonylcarbamoyladenosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [PMID:23242255] is_a: GO:0006400 ! tRNA modification created_by: dph creation_date: 2013-01-22T14:25:00Z [Term] id: GO:0061506 name: obsolete DNA topoisomerase type II (ATP-independent) activity namespace: molecular_function def: "OBSOLETE. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:dph] comment: This term was made obsolete because there is no evidence that this function exists. There are no known type II topoisomerase enzymes that are ATP-independent; as far as we know, ALL type II topoisomerase enzymes utilize hydrolysis of ATP. is_obsolete: true created_by: dph creation_date: 2013-01-23T10:41:58Z [Term] id: GO:0061507 name: cyclic-GMP-AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide." [GOC:dph, PMID:23258412] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding created_by: dph creation_date: 2013-01-24T15:38:27Z [Term] id: GO:0061508 name: CDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into CDP to produce a CTP." [PMID:7499258] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation created_by: dph creation_date: 2013-02-21T13:38:11Z [Term] id: GO:0061509 name: asymmetric protein localization to old mitotic spindle pole body namespace: biological_process def: "Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw] is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body is_a: GO:1902440 ! protein localization to mitotic spindle pole body created_by: dph creation_date: 2013-02-21T13:49:26Z [Term] id: GO:0061510 name: asymmetric protein localization to new mitotic spindle pole body namespace: biological_process def: "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw] is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body is_a: GO:1902440 ! protein localization to mitotic spindle pole body created_by: dph creation_date: 2013-02-21T13:49:54Z [Term] id: GO:0061511 name: centriole elongation namespace: biological_process def: "The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007099 ! centriole replication created_by: dph creation_date: 2013-03-22T09:06:27Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle created_by: dph creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061513 name: glucose 6-phosphate:inorganic phosphate antiporter activity namespace: molecular_function alt_id: GO:0008524 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out)." [GOC:dph, PMID:18337460] synonym: "glucose 6-phosphate:phosphate antiporter activity" BROAD [] xref: Reactome:R-HSA-198513 "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4" xref: Reactome:R-HSA-3229118 "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane" xref: Reactome:R-HSA-3257122 "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015526 ! hexose-phosphate:inorganic phosphate antiporter activity created_by: dph creation_date: 2013-04-17T08:47:40Z [Term] id: GO:0061514 name: interleukin-34-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-34 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:18467591] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: dph creation_date: 2013-04-18T13:00:33Z [Term] id: GO:0061515 name: myeloid cell development namespace: biological_process def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030099 ! myeloid cell differentiation created_by: dph creation_date: 2013-04-18T13:03:16Z [Term] id: GO:0061516 name: monocyte proliferation namespace: biological_process def: "The expansion of a monocyte population by cell division." [GOC:dph, PMID:18467591] is_a: GO:0070661 ! leukocyte proliferation created_by: dph creation_date: 2013-04-18T13:14:24Z [Term] id: GO:0061517 name: macrophage proliferation namespace: biological_process def: "The expansion of a macrophage population by cell division." [GOC:dph, PMID:12614284, PMID:19466391] is_a: GO:0070661 ! leukocyte proliferation created_by: dph creation_date: 2013-04-18T13:17:56Z [Term] id: GO:0061518 name: microglial cell proliferation namespace: biological_process def: "The expansion of a microglial cell population by cell division." [GOC:dph, PMID:17344397] is_a: GO:0014009 ! glial cell proliferation is_a: GO:0061517 ! macrophage proliferation created_by: dph creation_date: 2013-04-18T13:20:21Z [Term] id: GO:0061519 name: macrophage homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis created_by: dph creation_date: 2013-04-18T13:25:33Z [Term] id: GO:0061520 name: Langerhans cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a Langerhans cell." [GOC:dph, PMID:22729249] is_a: GO:0043011 ! myeloid dendritic cell differentiation created_by: dph creation_date: 2013-04-18T13:29:07Z [Term] id: GO:0061521 name: hepatic stellate cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell." [GOC:dph, PMID:9407545] is_a: GO:0030154 ! cell differentiation created_by: dph creation_date: 2013-04-18T13:36:08Z [Term] id: GO:0061522 name: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA." [GOC:dph] is_a: GO:0016289 ! CoA hydrolase activity created_by: dph creation_date: 2013-04-18T14:37:32Z [Term] id: GO:0061523 name: cilium disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "cilium resorption" EXACT [GOC:dph] is_a: GO:0044782 ! cilium organization is_a: GO:1903008 ! organelle disassembly created_by: dph creation_date: 2013-04-18T14:59:59Z [Term] id: GO:0061524 name: central canal development namespace: biological_process def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development created_by: dph creation_date: 2013-04-20T08:18:31Z [Term] id: GO:0061525 name: hindgut development namespace: biological_process def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph] is_a: GO:0048565 ! digestive tract development created_by: dph creation_date: 2013-06-14T11:22:21Z [Term] id: GO:0061526 name: acetylcholine secretion namespace: biological_process def: "The regulated release of acetylcholine by a cell." [GOC:dph] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0032940 ! secretion by cell created_by: dph creation_date: 2013-06-21T15:40:39Z [Term] id: GO:0061527 name: dopamine secretion, neurotransmission namespace: biological_process def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0099124 ! axonal dopamine secretion relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic created_by: dph creation_date: 2013-06-21T15:43:15Z [Term] id: GO:0061528 name: aspartate secretion namespace: biological_process def: "The regulated release of aspartate by a cell." [GOC:dph] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion created_by: dph creation_date: 2013-06-21T15:45:37Z [Term] id: GO:0061529 name: epinephrine secretion, neurotransmission namespace: biological_process def: "The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter." [GOC:dph] synonym: "adrenaline secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048242 ! epinephrine secretion created_by: dph creation_date: 2013-06-21T15:47:22Z [Term] id: GO:0061530 name: aspartate secretion, neurotransmission namespace: biological_process def: "The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061528 ! aspartate secretion created_by: dph creation_date: 2013-06-21T15:50:10Z [Term] id: GO:0061531 name: primary amine secretion namespace: biological_process def: "The regulated release of a primary amine by a cell." [GOC:dph] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015837 ! amine transport is_a: GO:0032940 ! secretion by cell created_by: dph creation_date: 2013-06-21T15:56:08Z [Term] id: GO:0061532 name: primary amine secretion, neurotransmission namespace: biological_process def: "The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter." [GOC:dph] is_a: GO:0061545 ! tyramine secretion created_by: dph creation_date: 2013-06-21T15:57:12Z [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission namespace: biological_process def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph] synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0048243 ! norepinephrine secretion created_by: dph creation_date: 2013-06-21T16:05:08Z [Term] id: GO:0061534 name: gamma-aminobutyric acid secretion, neurotransmission namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014051 ! gamma-aminobutyric acid secretion relationship: part_of GO:0051932 ! synaptic transmission, GABAergic created_by: dph creation_date: 2013-06-21T16:10:50Z [Term] id: GO:0061535 name: glutamate secretion, neurotransmission namespace: biological_process def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014047 ! glutamate secretion relationship: part_of GO:0035249 ! synaptic transmission, glutamatergic created_by: dph creation_date: 2013-06-21T16:14:47Z [Term] id: GO:0061536 name: glycine secretion namespace: biological_process def: "The controlled release of glycine by a cell." [GOC:dph] is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion created_by: dph creation_date: 2013-06-21T16:18:23Z [Term] id: GO:0061537 name: glycine secretion, neurotransmission namespace: biological_process def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061536 ! glycine secretion relationship: part_of GO:0060012 ! synaptic transmission, glycinergic created_by: dph creation_date: 2013-06-21T16:19:02Z [Term] id: GO:0061538 name: histamine secretion, neurotransmission namespace: biological_process def: "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter." [GOC:dph] is_a: GO:0001821 ! histamine secretion is_a: GO:0007269 ! neurotransmitter secretion created_by: dph creation_date: 2013-06-21T16:21:21Z [Term] id: GO:0061539 name: octopamine secretion namespace: biological_process def: "The controlled release of octopamine by a cell." [GOC:dph] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0032940 ! secretion by cell created_by: dph creation_date: 2013-06-21T16:24:02Z [Term] id: GO:0061540 name: octopamine secretion, neurotransmission namespace: biological_process def: "The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061539 ! octopamine secretion created_by: dph creation_date: 2013-06-21T16:24:47Z [Term] id: GO:0061541 name: rhabdomere morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [GOC:dph, PMID:22113834] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0008594 ! photoreceptor cell morphogenesis relationship: part_of GO:0042052 ! rhabdomere development created_by: dph creation_date: 2013-06-24T07:59:25Z [Term] id: GO:0061542 name: 3-demethylubiquinone-n 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n." [EC:2.1.1.64, GOC:dph] synonym: "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase" NARROW [] synonym: "5-demethylubiquinone-10 methyltransferase" NARROW [] synonym: "5-demethylubiquinone-9 methyltransferase" NARROW [] synonym: "OMHMB-methyltransferase" RELATED [] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase" RELATED [] is_a: GO:0008171 ! O-methyltransferase activity created_by: dph creation_date: 2013-06-25T08:01:46Z [Term] id: GO:0061543 name: 3-demethylubiquinone-6 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-6 = S-adenosyl-L-homocysteine + ubiquinone-6." [GOC:dph] is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity created_by: dph creation_date: 2013-06-25T08:05:14Z [Term] id: GO:0061544 name: peptide secretion, neurotransmission namespace: biological_process def: "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter." [GOC:dph] is_a: GO:0002790 ! peptide secretion is_a: GO:0007269 ! neurotransmitter secretion created_by: dph creation_date: 2013-06-25T09:10:10Z [Term] id: GO:0061545 name: tyramine secretion namespace: biological_process def: "The regulated release of a tyramine by a cell." [GOC:dph] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0061531 ! primary amine secretion created_by: dph creation_date: 2013-06-25T09:14:07Z [Term] id: GO:0061546 name: tyramine secretion, neurotransmission namespace: biological_process def: "The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter." [GOC:dph] is_a: GO:0061532 ! primary amine secretion, neurotransmission created_by: dph creation_date: 2013-06-25T09:16:47Z [Term] id: GO:0061547 name: glycogen synthase activity, transferring glucose-1-phosphate namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517] xref: Reactome:R-HSA-3780994 "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2" xref: Reactome:R-HSA-3781024 "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups created_by: dph creation_date: 2013-07-02T09:59:18Z [Term] id: GO:0061548 name: ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "ganglia development" RELATED [GOC:dph] synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl] is_a: GO:0009888 ! tissue development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007399 ! nervous system development created_by: dph creation_date: 2013-07-10T08:36:12Z [Term] id: GO:0061549 name: sympathetic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl] synonym: "sympathetic ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development relationship: part_of GO:0048485 ! sympathetic nervous system development created_by: dph creation_date: 2013-07-10T08:38:01Z [Term] id: GO:0061550 name: cranial ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "cranial ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development relationship: part_of GO:0021545 ! cranial nerve development created_by: dph creation_date: 2013-07-10T08:40:14Z [Term] id: GO:0061551 name: trigeminal ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "trigeminal ganglia development" RELATED [GOC:dph] is_a: GO:0061550 ! cranial ganglion development created_by: dph creation_date: 2013-07-10T08:42:19Z [Term] id: GO:0061552 name: ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph] synonym: "ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0061548 ! ganglion development created_by: dph creation_date: 2013-07-10T08:44:57Z [Term] id: GO:0061553 name: ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] synonym: "ganglia maturation" RELATED [GOC:dph] is_a: GO:0048799 ! animal organ maturation relationship: part_of GO:0061548 ! ganglion development created_by: dph creation_date: 2013-07-10T08:45:59Z [Term] id: GO:0061554 name: ganglion formation namespace: biological_process def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "ganglia formation" RELATED [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0061552 ! ganglion morphogenesis created_by: dph creation_date: 2013-07-10T08:51:50Z [Term] id: GO:0061555 name: ganglion structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] synonym: "ganglia structural organization" RELATED [GOC:dph] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0061552 ! ganglion morphogenesis created_by: dph creation_date: 2013-07-10T08:54:39Z [Term] id: GO:0061556 name: trigeminal ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph] synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061559 ! cranial ganglion morphogenesis relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis relationship: part_of GO:0061551 ! trigeminal ganglion development created_by: dph creation_date: 2013-07-10T08:57:12Z [Term] id: GO:0061557 name: trigeminal ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] is_a: GO:0061558 ! cranial ganglion maturation relationship: part_of GO:0021635 ! trigeminal nerve maturation relationship: part_of GO:0061551 ! trigeminal ganglion development created_by: dph creation_date: 2013-07-10T08:58:24Z [Term] id: GO:0061558 name: cranial ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] synonym: "cranial ganglia maturation" RELATED [GOC:dph] is_a: GO:0061553 ! ganglion maturation relationship: part_of GO:0021605 ! cranial nerve maturation relationship: part_of GO:0061550 ! cranial ganglion development created_by: dph creation_date: 2013-07-10T08:59:52Z [Term] id: GO:0061559 name: cranial ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph] synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061552 ! ganglion morphogenesis relationship: part_of GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0061550 ! cranial ganglion development created_by: dph creation_date: 2013-07-10T09:02:15Z [Term] id: GO:0061560 name: cranial ganglion formation namespace: biological_process def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "cranial ganglia formation" RELATED [GOC:dph] is_a: GO:0061554 ! ganglion formation relationship: part_of GO:0061559 ! cranial ganglion morphogenesis created_by: dph creation_date: 2013-07-10T09:07:27Z [Term] id: GO:0061561 name: trigeminal ganglion formation namespace: biological_process def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "trigeminal ganglia formation" RELATED [GOC:dph] is_a: GO:0061560 ! cranial ganglion formation relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis created_by: dph creation_date: 2013-07-10T09:08:13Z [Term] id: GO:0061562 name: cranial ganglion structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] synonym: "cranial ganglia structural organization" RELATED [GOC:dph] is_a: GO:0061555 ! ganglion structural organization relationship: part_of GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0061559 ! cranial ganglion morphogenesis created_by: dph creation_date: 2013-07-10T09:10:52Z [Term] id: GO:0061563 name: trigeminal ganglion structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] synonym: "trigeminal ganglia organization" RELATED [GOC:dph] is_a: GO:0061562 ! cranial ganglion structural organization relationship: part_of GO:0021637 ! trigeminal nerve structural organization relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis created_by: dph creation_date: 2013-07-10T09:12:11Z [Term] id: GO:0061564 name: axon development namespace: biological_process def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] is_a: GO:0031175 ! neuron projection development created_by: dph creation_date: 2013-07-18T14:43:01Z [Term] id: GO:0061565 name: dAMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP." [GOC:dph, PMID:23416111] is_a: GO:0046940 ! nucleoside monophosphate phosphorylation created_by: dph creation_date: 2013-08-01T12:50:38Z [Term] id: GO:0061566 name: CMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP." [GOC:dph, PMID:23416111] is_a: GO:0046940 ! nucleoside monophosphate phosphorylation created_by: dph creation_date: 2013-08-01T12:52:39Z [Term] id: GO:0061567 name: dCMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP." [GOC:dph, PMID:23416111] is_a: GO:0046940 ! nucleoside monophosphate phosphorylation created_by: dph creation_date: 2013-08-01T12:54:21Z [Term] id: GO:0061568 name: GDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP." [GOC:dph, PMID:23416111] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation created_by: dph creation_date: 2013-08-01T12:57:12Z [Term] id: GO:0061569 name: UDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP." [GOC:dph, PMID:23416111] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation created_by: dph creation_date: 2013-08-01T12:59:32Z [Term] id: GO:0061570 name: dCDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dCDP to produce a dCTP." [GOC:dph, PMID:23416111] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation created_by: dph creation_date: 2013-08-01T13:02:16Z [Term] id: GO:0061571 name: TDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into TDP to produce a TTP." [GOC:dph, PMID:23416111] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation created_by: dph creation_date: 2013-08-01T13:03:34Z [Term] id: GO:0061572 name: actin filament bundle organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] synonym: "actin filament cable organization" RELATED [GOC:dph] is_a: GO:0007015 ! actin filament organization created_by: dph creation_date: 2013-08-02T11:24:11Z [Term] id: GO:0061573 name: actin filament bundle retrograde transport namespace: biological_process def: "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell." [GOC:dph] synonym: "actin filament cable retrograde transport" RELATED [GOC:dph] is_a: GO:0070650 ! actin filament bundle distribution created_by: dph creation_date: 2013-08-02T11:31:04Z [Term] id: GO:0061574 name: ASAP complex namespace: cellular_component def: "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2013-10-08T13:09:16Z [Term] id: GO:0061575 name: cyclin-dependent protein serine/threonine kinase activator activity namespace: molecular_function alt_id: GO:0016534 alt_id: GO:0016535 def: "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] synonym: "cyclin-dependent protein kinase 5 activator activity" NARROW [] is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity is_a: GO:0043539 ! protein serine/threonine kinase activator activity relationship: part_of GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity created_by: dph creation_date: 2013-10-08T13:50:35Z [Term] id: GO:0061576 name: acyl-CoA ceramide synthase complex namespace: cellular_component def: "A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1." [GOC:dph, PMID:15692566] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2013-10-24T14:42:06Z [Term] id: GO:0061577 name: calcium ion transmembrane transport via high voltage-gated calcium channel namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel." [GOC:dph] synonym: "generation of L-type calcium current" RELATED [] is_a: GO:0070588 ! calcium ion transmembrane transport relationship: has_part GO:0008331 ! high voltage-gated calcium channel activity created_by: dph creation_date: 2013-11-15T16:20:27Z [Term] id: GO:0061578 name: Lys63-specific deubiquitinase activity namespace: molecular_function def: "Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:dph, GOC:pg, PMID:18313383] xref: Reactome:R-HSA-5357845 "RIPK1 is deubiquitinated" xref: Reactome:R-HSA-5690856 "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1" xref: Reactome:R-HSA-5691411 "BRCA1-A complex deubiquitinates K63polyUb-histone H2A" xref: Reactome:R-HSA-5691431 "PSMD14 cleaves K63-linked ubiquitin" xref: Reactome:R-HSA-5691439 "BRISC complex deubiquitinates NLRP3" xref: Reactome:R-HSA-5696547 "STAMBPL1 is a deubiquitinase" xref: Reactome:R-HSA-688136 "TNFAIP3 (A20) deubiquitinates RIP2" xref: Reactome:R-HSA-741411 "CYLD deubiquitinates NEMO" xref: Reactome:R-HSA-8869506 "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6" xref: Reactome:R-HSA-936381 "OTUD5 deubiquitinates TRAF3" xref: Reactome:R-HSA-936390 "CYLD mediated deubiquitination of DDX58 (RIG-I)" is_a: GO:0101005 ! ubiquitinyl hydrolase activity relationship: part_of GO:0070536 ! protein K63-linked deubiquitination created_by: dph creation_date: 2013-11-15T19:13:12Z [Term] id: GO:0061579 name: N-acyl homoserine lactone synthase activity namespace: molecular_function def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph] synonym: "autoinducer-1 synthase" RELATED [GOC:dph] xref: EC:2.3.1.184 is_a: GO:0016410 ! N-acyltransferase activity created_by: dph creation_date: 2013-11-15T19:48:23Z [Term] id: GO:0061580 name: colon epithelial cell migration namespace: biological_process def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0061582 ! intestinal epithelial cell migration created_by: dph creation_date: 2013-12-23T07:26:54Z [Term] id: GO:0061581 name: corneal epithelial cell migration namespace: biological_process def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0010631 ! epithelial cell migration created_by: dph creation_date: 2013-12-23T07:28:29Z [Term] id: GO:0061582 name: intestinal epithelial cell migration namespace: biological_process def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0010631 ! epithelial cell migration created_by: dph creation_date: 2013-12-23T07:30:55Z [Term] id: GO:0061583 name: colon epithelial cell chemotaxis namespace: biological_process def: "The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] is_a: GO:0060326 ! cell chemotaxis is_a: GO:0061580 ! colon epithelial cell migration created_by: dph creation_date: 2013-12-23T07:46:57Z [Term] id: GO:0061584 name: hypocretin secretion namespace: biological_process def: "The controlled release of hypocretin from a cell or a tissue." [GOC:dph] synonym: "orexin secretion" EXACT [GOC:dph] is_a: GO:0002790 ! peptide secretion created_by: dph creation_date: 2013-12-26T10:07:38Z [Term] id: GO:0061585 name: hypocretin secretion, neurotransmission namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter." [GOC:dph] synonym: "orexin secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0061544 ! peptide secretion, neurotransmission is_a: GO:0061584 ! hypocretin secretion created_by: dph creation_date: 2013-12-26T10:09:37Z [Term] id: GO:0061586 name: positive regulation of transcription by transcription factor localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph] is_a: GO:0034613 ! cellular protein localization is_a: GO:0045893 ! positive regulation of transcription, DNA-templated created_by: dph creation_date: 2014-01-31T08:43:43Z [Term] id: GO:0061587 name: transfer RNA gene-mediated silencing namespace: biological_process def: "The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes." [GOC:dph, PMID:23707796] synonym: "tgm silencing" EXACT [PMID:23707796] synonym: "transfer RNA gene-mediated chromatin silencing" EXACT [GOC:dph] synonym: "transfer RNA gene-mediated gene silencing" EXACT [GOC:dph] synonym: "tRNA gene-mediated chromatin silencing" EXACT [GOC:dph] synonym: "tRNA gene-mediated gene silencing" EXACT [GOC:dph] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0006342 ! chromatin silencing created_by: dph creation_date: 2014-02-05T09:03:59Z [Term] id: GO:0061588 name: calcium activated phospholipid scrambling namespace: biological_process def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] is_a: GO:0017121 ! plasma membrane phospholipid scrambling created_by: dph creation_date: 2014-02-05T15:14:34Z [Term] id: GO:0061589 name: calcium activated phosphatidylserine scrambling namespace: biological_process def: "The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] is_a: GO:0061588 ! calcium activated phospholipid scrambling created_by: dph creation_date: 2014-02-05T15:17:21Z [Term] id: GO:0061590 name: calcium activated phosphatidylcholine scrambling namespace: biological_process def: "The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] is_a: GO:0061588 ! calcium activated phospholipid scrambling created_by: dph creation_date: 2014-02-05T15:23:03Z [Term] id: GO:0061591 name: calcium activated galactosylceramide scrambling namespace: biological_process def: "The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] is_a: GO:0061588 ! calcium activated phospholipid scrambling created_by: dph creation_date: 2014-02-05T15:25:52Z [Term] id: GO:0061592 name: phosphatidylserine exposure on osteoblast involved in bone mineralization namespace: biological_process def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization." [GOC:krc, PMID:22936354] is_a: GO:0017121 ! plasma membrane phospholipid scrambling relationship: part_of GO:0030282 ! bone mineralization created_by: dph creation_date: 2014-02-05T15:27:39Z [Term] id: GO:0061593 name: sulfoquinovose isomerase activity namespace: molecular_function def: "Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose." [GOC:dph, PMID:24463506] is_a: GO:0016853 ! isomerase activity created_by: dph creation_date: 2014-02-10T09:56:04Z [Term] id: GO:0061594 name: 6-deoxy-6-sulfofructose kinase activity namespace: molecular_function def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506] xref: EC:2.7.1.184 xref: MetaCyc:RXN-15297 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: dph creation_date: 2014-02-10T09:59:26Z [Term] id: GO:0061595 name: 6-deoxy-6-sulfofructose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate." [PMID:24463506] is_a: GO:0016832 ! aldehyde-lyase activity created_by: dph creation_date: 2014-02-10T10:05:27Z [Term] id: GO:0061596 name: 3-sulfolactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [EC:1.1.1.373, GOC:dph, PMID:24463506] xref: EC:1.1.1.373 xref: MetaCyc:RXN-15299 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: dph creation_date: 2014-02-10T10:09:43Z [Term] id: GO:0061597 name: obsolete cyclic pyranopterin monophosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309] comment: This term was made obsolete because it represents two distinct molecular functions. is_obsolete: true created_by: dph creation_date: 2014-02-10T13:54:19Z [Term] id: GO:0061598 name: molybdopterin adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin." [EC:2.7.7.75, GOC:dph] xref: EC:2.7.7.75 xref: RHEA:31331 is_a: GO:0070566 ! adenylyltransferase activity created_by: dph creation_date: 2014-02-10T14:14:06Z [Term] id: GO:0061599 name: molybdopterin molybdotransferase activity namespace: molecular_function def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph] xref: EC:2.10.1.1 xref: Reactome:R-HSA-947531 "Molybdenum ion transfer onto molybdopterin" is_a: GO:0016740 ! transferase activity created_by: dph creation_date: 2014-02-10T14:30:31Z [Term] id: GO:0061602 name: molybdenum cofactor cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph] xref: EC:2.7.7.76 is_a: GO:0070567 ! cytidylyltransferase activity created_by: dph creation_date: 2014-02-10T14:46:38Z [Term] id: GO:0061603 name: molybdenum cofactor guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph] xref: EC:2.7.7.77 is_a: GO:0070568 ! guanylyltransferase activity created_by: dph creation_date: 2014-02-10T14:54:36Z [Term] id: GO:0061604 name: molybdopterin-synthase sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186] xref: EC:2.8.1.11 is_a: GO:0016783 ! sulfurtransferase activity created_by: dph creation_date: 2014-02-11T11:56:16Z [Term] id: GO:0061605 name: molybdopterin-synthase adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186] xref: EC:2.7.7.80 is_a: GO:0070566 ! adenylyltransferase activity created_by: dph creation_date: 2014-02-11T12:01:32Z [Term] id: GO:0061606 name: N-terminal protein amino acid propionylation namespace: biological_process def: "The propionylation of the N-terminal amino acid of proteins." [GOC:dph, PMID:17267393, PMID:23043182] is_a: GO:0043687 ! post-translational protein modification created_by: dph creation_date: 2014-02-11T14:13:05Z [Term] id: GO:0061607 name: peptide alpha-N-propionyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein." [GOC:dph, PMID:23043182] synonym: "N-terminal propionyltransferase activity" EXACT [PMID:23043182] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0061606 ! N-terminal protein amino acid propionylation created_by: dph creation_date: 2014-02-11T14:24:35Z [Term] id: GO:0061608 name: nuclear import signal receptor activity namespace: molecular_function def: "Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport] comment: Changed parents, updated definition see https://github.com/geneontology/go-ontology/issues/14336 synonym: "importin activity" RELATED [] is_a: GO:0140142 ! nucleocytoplasmic carrier activity intersection_of: GO:0140142 ! nucleocytoplasmic carrier activity intersection_of: part_of GO:0051170 ! import into nucleus relationship: part_of GO:0051170 ! import into nucleus created_by: dph creation_date: 2014-03-03T07:58:18Z [Term] id: GO:0061609 name: fructose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde." [GOC:dph, GOC:glycolysis, ISBN:0201090910, RHEA:30851] xref: Reactome:R-HSA-5656438 "Defective ALDOB does not cleave Fru 1-P to GA and DHAP" xref: Reactome:R-HSA-70342 "ALDOB tetramer cleaves Fru-1-P to GA and DHAP" xref: RHEA:30851 is_a: GO:0016832 ! aldehyde-lyase activity created_by: dph creation_date: 2014-03-28T08:54:24Z [Term] id: GO:0061610 name: glycerol to glycerone phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate." [GOC:dph, ISBN:0201090910] synonym: "glycerol metabolism to DHAP" EXACT [GOC:dph] synonym: "glycerol metabolism to dihydroxyacetone phosphate" EXACT [GOC:dph] synonym: "glycerol metabolism to glycerone phosphate" EXACT [GOC:dph] synonym: "glycerol to DHAP metabolic process" EXACT [GOC:dph] synonym: "glycerol to dihydroxyacetone phosphate metabolic process" EXACT [GOC:dph] is_a: GO:0006071 ! glycerol metabolic process relationship: has_part GO:0004367 ! glycerol-3-phosphate dehydrogenase [NAD+] activity created_by: dph creation_date: 2014-04-03T13:26:21Z [Term] id: GO:0061611 name: mannose to fructose-6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] synonym: "mannose metabolism to fructose-6-phosphate" EXACT [GOC:dph] is_a: GO:0006013 ! mannose metabolic process created_by: dph creation_date: 2014-04-03T13:38:50Z [Term] id: GO:0061612 name: galactose to glucose-1-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] is_a: GO:0006012 ! galactose metabolic process relationship: has_part GO:0003978 ! UDP-glucose 4-epimerase activity created_by: dph creation_date: 2014-04-04T08:18:49Z [Term] id: GO:0061613 name: glycolytic process from glycerol namespace: biological_process def: "The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH." [GOC:dph, ISBN:0201090910] is_a: GO:0006096 ! glycolytic process is_a: GO:0019563 ! glycerol catabolic process relationship: has_part GO:0004807 ! triose-phosphate isomerase activity created_by: dph creation_date: 2014-04-04T08:26:57Z [Term] id: GO:0061614 name: pri-miRNA transcription by RNA polymerase II namespace: biological_process def: "The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "pri-miRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006366 ! transcription by RNA polymerase II created_by: dph creation_date: 2014-04-08T08:42:54Z [Term] id: GO:0061615 name: glycolytic process through fructose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] synonym: "glycolysis through fructose-6-phosphate" EXACT [GOC:dph] xref: MetaCyc:PWY-5484 is_a: GO:0006096 ! glycolytic process intersection_of: GO:0006096 ! glycolytic process intersection_of: has_part GO:0003872 ! 6-phosphofructokinase activity intersection_of: has_part GO:0004332 ! fructose-bisphosphate aldolase activity intersection_of: has_part GO:0004807 ! triose-phosphate isomerase activity relationship: has_part GO:0003872 ! 6-phosphofructokinase activity relationship: has_part GO:0004332 ! fructose-bisphosphate aldolase activity relationship: has_part GO:0004807 ! triose-phosphate isomerase activity created_by: dph creation_date: 2014-04-08T10:08:49Z [Term] id: GO:0061616 name: glycolytic process from fructose through fructose-6-phosphate namespace: biological_process def: "The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] synonym: "glycolysis from fructose through fructose-6-phosphate" EXACT [GOC:dph] xref: MetaCyc:PWY-5484 is_a: GO:0006001 ! fructose catabolic process is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate created_by: dph creation_date: 2014-04-08T10:20:37Z [Term] id: GO:0061617 name: MICOS complex namespace: cellular_component def: "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277] synonym: "Fcj1 complex" EXACT [GOC:dph] synonym: "MINOS complex" EXACT [GOC:dph] synonym: "mitochondrial contact site and cristae organizing system" EXACT [GOC:dph] synonym: "MitOS complex" EXACT [GOC:dph] is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane created_by: dph creation_date: 2014-04-14T07:18:13Z [Term] id: GO:0061618 name: obsolete sublamina densa namespace: cellular_component def: "OBSOLETE. The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers." [GOC:BHF, PMID:15623520] comment: This term was made obsolete because it is thought to be an experimental artefact. is_obsolete: true created_by: dph creation_date: 2014-04-14T08:43:13Z [Term] id: GO:0061619 name: glycolytic process from mannose through fructose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] is_a: GO:0019309 ! mannose catabolic process is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate created_by: dph creation_date: 2014-04-14T09:13:13Z [Term] id: GO:0061620 name: glycolytic process through glucose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] xref: MetaCyc:GLYCOLYSIS is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate relationship: has_part GO:0004347 ! glucose-6-phosphate isomerase activity created_by: dph creation_date: 2014-04-14T09:17:48Z [Term] id: GO:0061621 name: canonical glycolysis namespace: biological_process def: "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] xref: MetaCyc:ANAGLYCOLYSIS-PWY xref: MetaCyc:PWY66-400 xref: Reactome:R-HSA-70171 "Glycolysis, Homo sapiens" xref: Wikipedia:Glycolysis is_a: GO:0006735 ! NADH regeneration is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate is_a: GO:0061718 ! glucose catabolic process to pyruvate relationship: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity created_by: dph creation_date: 2014-04-14T09:21:54Z [Term] id: GO:0061622 name: glycolytic process through glucose-1-phosphate namespace: biological_process def: "The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910] is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate intersection_of: GO:0061620 ! glycolytic process through glucose-6-phosphate intersection_of: has_part GO:0004614 ! phosphoglucomutase activity relationship: has_part GO:0004614 ! phosphoglucomutase activity created_by: dph creation_date: 2014-04-28T08:08:01Z [Term] id: GO:0061623 name: glycolytic process from galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910] is_a: GO:0019388 ! galactose catabolic process is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate created_by: dph creation_date: 2014-04-28T08:13:38Z [Term] id: GO:0061624 name: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate." [GOC:dph, ISBN:0201090910] is_a: GO:0006001 ! fructose catabolic process is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process relationship: has_part GO:0050354 ! triokinase activity relationship: has_part GO:0061609 ! fructose-1-phosphate aldolase activity created_by: dph creation_date: 2014-04-29T12:58:28Z [Term] id: GO:0061625 name: glycolytic process through fructose-1-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910] is_a: GO:0006001 ! fructose catabolic process is_a: GO:0006096 ! glycolytic process relationship: has_part GO:0004807 ! triose-phosphate isomerase activity created_by: dph creation_date: 2014-04-29T13:04:10Z [Term] id: GO:0061626 name: pharyngeal arch artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914] synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph] is_a: GO:0048844 ! artery morphogenesis relationship: part_of GO:0060037 ! pharyngeal system development created_by: dph creation_date: 2014-05-09T15:34:06Z [Term] id: GO:0061627 name: S-methylmethionine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+." [EC:2.1.1.10, GOC:BHF, GOC:dph] synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10] synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] xref: Reactome:R-HSA-5696838 "BHMT2 tetramer transfers CH3 group from SMM to LHCYS" xref: RHEA:26337 is_a: GO:0008172 ! S-methyltransferase activity created_by: dph creation_date: 2014-05-14T14:32:02Z [Term] id: GO:0061628 name: H3K27me3 modified histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 27 has been modified by trimethylation." [GOC:dph, PMID:23948251] synonym: "H3-K27me3 modified histone binding" EXACT [GOC:dph] is_a: GO:0035064 ! methylated histone binding created_by: dph creation_date: 2014-05-14T15:36:53Z [Term] id: GO:0061629 name: RNA polymerase II-specific DNA-binding transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT [] synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT [] is_a: GO:0140297 ! DNA-binding transcription factor binding created_by: dph creation_date: 2014-05-15T09:12:24Z [Term] id: GO:0061630 name: ubiquitin protein ligase activity namespace: molecular_function alt_id: GO:0090302 alt_id: GO:0090622 alt_id: GO:1904264 alt_id: GO:1904822 def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777] comment: This enzyme catalyzes a transferase reaction. synonym: "APC-Cdc20 complex activity" NARROW [GOC:vw] synonym: "APC-fizzy related complex activity" NARROW [GOC:vw] synonym: "E3" RELATED [GOC:dph] synonym: "E3 involved in endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] synonym: "ER-associated E3 ligase" RELATED [PMID:24019521] synonym: "protein ubiquitination activity" EXACT [GOC:dph] synonym: "ubiquitin ligase activity" EXACT [GOC:dph] synonym: "ubiquitin ligase activity involved in ER-associated degradation pathway" NARROW [GOC:TermGenie] synonym: "ubiquitin protein ligase activity involved in chloroplast disassembly" NARROW [] synonym: "ubiquitin protein ligase activity involved in ER-associated degradation pathway" NARROW [GOC:TermGenie] synonym: "ubiquitin protein ligase activity involved in ERAD pathway" NARROW [] synonym: "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition" NARROW [GOC:dph, GOC:mah, GOC:tb] xref: Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL" xref: Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1" xref: Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8" xref: Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE" xref: Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN" xref: Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1" xref: Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2" xref: Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1" xref: Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization" xref: Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation" xref: Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated" xref: Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1" xref: Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1" xref: Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3" xref: Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1" xref: Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1" xref: Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2" xref: Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3" xref: Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4" xref: Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1" xref: Reactome:R-HSA-5674022 "BRAP autoubiquitinates" xref: Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX" xref: Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1" xref: Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal" xref: Reactome:R-HSA-5689111 "PARK2 autoubiquitinates" xref: Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1" xref: Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II" xref: Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC" xref: Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI" xref: Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC" xref: Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2" xref: Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY" xref: Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53" xref: Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4" xref: Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53" xref: Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate" xref: Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination" xref: Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN" xref: Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin" xref: Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex" xref: Reactome:R-HSA-8848829 "CBL autoubiquitinates" xref: Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN" xref: Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA" xref: Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7" xref: Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839" xref: Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR" xref: Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del" xref: Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5" xref: Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET" xref: Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination" xref: Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET" xref: Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex" xref: Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC" xref: Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA" xref: Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10" xref: Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2" xref: Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B" xref: Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA" xref: Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA" xref: Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11" xref: Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN" xref: Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN" xref: Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3" xref: Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3" xref: Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11" xref: Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5" xref: Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73" xref: Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2" xref: Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2" xref: Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2" xref: Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2" xref: Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1" xref: Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3" xref: Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11" xref: Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL" xref: Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation" xref: Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216" xref: Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4" xref: Reactome:R-HSA-990526 "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1" is_a: GO:0004842 ! ubiquitin-protein transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-05-18T09:11:21Z [Term] id: GO:0061631 name: ubiquitin conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph] synonym: "E2" RELATED [GOC:dph] synonym: "HECT E3" RELATED [GOC:dph] is_a: GO:0004842 ! ubiquitin-protein transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-05-18T09:25:19Z [Term] id: GO:0061632 name: RNA lariat debranching enzyme activator activity namespace: molecular_function def: "Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [GOC:dph, PMID:24919400] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0008419 ! RNA lariat debranching enzyme activity created_by: dph creation_date: 2014-06-17T10:07:31Z [Term] id: GO:0061633 name: transport-coupled glycolytic process through glucose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport." [GOC:dph] is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate is_a: GO:0061718 ! glucose catabolic process to pyruvate created_by: dph creation_date: 2014-06-19T09:12:37Z [Term] id: GO:0061634 name: alpha-D-xyloside xylohydrolase namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose." [EC:3.2.1.177] synonym: "alpha-xylosidase" EXACT [EC:3.2.1.177] xref: EC:3.2.1.177 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: dph creation_date: 2014-07-28T08:12:39Z [Term] id: GO:0061635 name: regulation of protein complex stability namespace: biological_process def: "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly." [GOC:dph] is_a: GO:0065008 ! regulation of biological quality created_by: dph creation_date: 2014-08-13T14:40:21Z [Term] id: GO:0061638 name: CENP-A containing chromatin namespace: cellular_component def: "The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment." [GOC:vw, PMID:20206496, PMID:22729156] synonym: "centromeric core domain chromatin" RELATED [GOC:vw] synonym: "centromeric core region chromatin" EXACT [GOC:vw] is_a: GO:0000785 ! chromatin relationship: part_of GO:0034506 ! chromosome, centromeric core domain created_by: dph creation_date: 2014-08-20T14:06:35Z [Term] id: GO:0061639 name: Cdv-dependent cytokinesis namespace: biological_process def: "A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells." [GOC:dph, PMID:18987308] is_a: GO:0000910 ! cytokinesis created_by: dph creation_date: 2014-08-21T14:55:04Z [Term] id: GO:0061640 name: cytoskeleton-dependent cytokinesis namespace: biological_process def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph] is_a: GO:0000910 ! cytokinesis created_by: dph creation_date: 2014-08-22T14:21:35Z [Term] id: GO:0061641 name: CENP-A containing chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin." [GOC:dph] synonym: "centromeric chromatin organization" RELATED [GOC:dph] is_a: GO:0006325 ! chromatin organization created_by: dph creation_date: 2014-08-27T12:26:14Z [Term] id: GO:0061642 name: chemoattraction of axon namespace: biological_process def: "The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:dph, GOC:krc] is_a: GO:0050918 ! positive chemotaxis intersection_of: GO:0050918 ! positive chemotaxis intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance relationship: part_of GO:0070887 ! cellular response to chemical stimulus created_by: dph creation_date: 2014-08-29T08:21:24Z [Term] id: GO:0061643 name: chemorepulsion of axon namespace: biological_process def: "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:dph, GOC:krc] is_a: GO:0050919 ! negative chemotaxis intersection_of: GO:0050919 ! negative chemotaxis intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance relationship: part_of GO:0070887 ! cellular response to chemical stimulus created_by: dph creation_date: 2014-08-29T08:35:40Z [Term] id: GO:0061644 name: protein localization to CENP-A containing chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin." [GOC:dph, GOC:vw] is_a: GO:0071168 ! protein localization to chromatin is_a: GO:0071459 ! protein localization to chromosome, centromeric region created_by: dph creation_date: 2014-08-29T12:17:05Z [Term] id: GO:0061645 name: endocytic patch namespace: cellular_component def: "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005938 ! cell cortex created_by: dph creation_date: 2014-09-02T09:23:38Z [Term] id: GO:0061646 name: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter." [GOC:pad, GOC:PARL] is_a: GO:0051716 ! cellular response to stimulus is_a: GO:1903296 ! positive regulation of glutamate secretion, neurotransmission created_by: dph creation_date: 2014-10-02T14:18:49Z [Term] id: GO:0061647 name: histone H3-K9 modification namespace: biological_process def: "The modification of histone H3 at a lysine in position 9 of the histone." [GOC:vw] is_a: GO:0016570 ! histone modification created_by: dph creation_date: 2014-10-02T15:07:42Z [Term] id: GO:0061648 name: tooth replacement namespace: biological_process def: "The process whose specific outcome is the replacement of an existing tooth with another tooth." [GOC:dph, PMID:15170864] is_a: GO:0042476 ! odontogenesis created_by: dph creation_date: 2014-10-02T15:26:53Z [Term] id: GO:0061649 name: ubiquitin modification-dependent histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:dph, PMID:24526689] synonym: "ubiquitinated histone binding" RELATED [] is_a: GO:0042393 ! histone binding is_a: GO:0140036 ! ubiquitin-dependent protein binding created_by: dph creation_date: 2014-11-04T10:21:04Z [Term] id: GO:0061650 name: ubiquitin-like protein conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [] synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:15:27Z [Term] id: GO:0061651 name: Atg12 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:17:36Z [Term] id: GO:0061652 name: FAT10 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0019775 ! FAT10 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:21:50Z [Term] id: GO:0061653 name: ISG15 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0042296 ! ISG15 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:24:50Z [Term] id: GO:0061654 name: NEDD8 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0019788 ! NEDD8 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:27:56Z [Term] id: GO:0061655 name: Pup conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity is_a: GO:0072496 ! Pup transferase activity created_by: dph creation_date: 2014-11-06T13:30:46Z [Term] id: GO:0061656 name: SUMO conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0019789 ! SUMO transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:33:20Z [Term] id: GO:0061657 name: UFM1 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity is_a: GO:0071568 ! UFM1 transferase activity created_by: dph creation_date: 2014-11-06T13:35:13Z [Term] id: GO:0061658 name: URM1 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" RELATED [GOC:dph] is_a: GO:0042294 ! URM1 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:37:26Z [Term] id: GO:0061659 name: ubiquitin-like protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:46:23Z [Term] id: GO:0061660 name: Atg12 ligase activity namespace: molecular_function def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:50:42Z [Term] id: GO:0061661 name: FAT10 ligase activity namespace: molecular_function def: "Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0019775 ! FAT10 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:53:10Z [Term] id: GO:0061662 name: ISG15 ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0042296 ! ISG15 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:54:48Z [Term] id: GO:0061663 name: NEDD8 ligase activity namespace: molecular_function def: "Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0019788 ! NEDD8 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:57:00Z [Term] id: GO:0061664 name: Pup ligase activity namespace: molecular_function def: "Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0061659 ! ubiquitin-like protein ligase activity is_a: GO:0072496 ! Pup transferase activity created_by: dph creation_date: 2014-11-06T13:59:09Z [Term] id: GO:0061665 name: SUMO ligase activity namespace: molecular_function def: "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0019789 ! SUMO transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T14:00:44Z [Term] id: GO:0061666 name: UFM1 ligase activity namespace: molecular_function def: "Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0061659 ! ubiquitin-like protein ligase activity is_a: GO:0071568 ! UFM1 transferase activity created_by: dph creation_date: 2014-11-06T14:02:37Z [Term] id: GO:0061667 name: URM1 ligase activity namespace: molecular_function def: "Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] is_a: GO:0042294 ! URM1 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T14:04:43Z [Term] id: GO:0061668 name: mitochondrial ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph] is_a: GO:0042255 ! ribosome assembly created_by: dph creation_date: 2014-11-07T15:32:20Z [Term] id: GO:0061669 name: spontaneous neurotransmitter secretion namespace: biological_process def: "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193] synonym: "stimulus-independent neurotransmitter secretion" EXACT [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion relationship: part_of GO:0098814 ! spontaneous synaptic transmission created_by: dph creation_date: 2014-11-17T07:52:35Z [Term] id: GO:0061670 name: evoked neurotransmitter secretion namespace: biological_process def: "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193] synonym: "stimulus-dependant neurotransmitter secretion" EXACT [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion created_by: dph creation_date: 2014-11-17T08:06:21Z [Term] id: GO:0061671 name: Cbp3p-Cbp6 complex namespace: cellular_component def: "A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly." [GOC:dph, GOC:rb, PMID:21670217] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2014-11-18T15:08:30Z [Term] id: GO:0061672 name: glutathione hydrolase complex namespace: cellular_component def: "Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly." [GOC:dph] synonym: "gamma-glutamyltranspeptidase complex" EXACT [GOC:dph] synonym: "glutamine amidotransferase II complex" NARROW [PMID:22277648] synonym: "glutathionase complex" EXACT [GOC:dph] is_a: GO:1905368 ! peptidase complex created_by: dph creation_date: 2014-11-24T14:38:08Z [Term] id: GO:0061673 name: mitotic spindle astral microtubule namespace: cellular_component def: "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] is_a: GO:0000235 ! astral microtubule intersection_of: GO:0000235 ! astral microtubule intersection_of: part_of GO:0072686 ! mitotic spindle relationship: part_of GO:0072686 ! mitotic spindle created_by: dph creation_date: 2014-12-08T18:27:20Z [Term] id: GO:0061674 name: gap filling involved in double-strand break repair via nonhomologous end joining namespace: biological_process def: "Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining." [GOC:dph] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: dph creation_date: 2015-01-05T10:07:32Z [Term] id: GO:0061675 name: RBL family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose." [PMID:22312473] synonym: "rhamnose-binding lectin family protein binding" EXACT [] is_a: GO:0005515 ! protein binding created_by: dph creation_date: 2015-01-10T18:22:42Z [Term] id: GO:0061676 name: importin-alpha family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the importin-alpha family." [PMID:15350979, PMID:17170104, PMID:23734157] is_a: GO:0005515 ! protein binding created_by: dph creation_date: 2015-01-10T18:25:22Z [Term] id: GO:0061677 name: 2-dehydro-3-deoxy-D-gluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate <=> pyruvate + D-glyceraldehyde." [EC:4.1.2.51, GOC:dph] xref: EC:4.1.2.51 xref: MetaCyc:4.1.2.51-RXN xref: RHEA:35583 is_a: GO:0016832 ! aldehyde-lyase activity created_by: dph creation_date: 2015-01-15T13:46:25Z [Term] id: GO:0061678 name: Entner-Doudoroff pathway namespace: biological_process def: "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate." [GOC:dph, PMID:12921536] xref: MetaCyc:Entner-Doudoroff-Pathways is_a: GO:0044275 ! cellular carbohydrate catabolic process created_by: dph creation_date: 2015-01-16T15:28:25Z [Term] id: GO:0061679 name: Entner-Doudoroff pathway through gluconate namespace: biological_process def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate." [GOC:dph, PMID:12921536] synonym: "gluconate pathway" RELATED [] is_a: GO:0061678 ! Entner-Doudoroff pathway relationship: has_part GO:0047929 ! gluconate dehydratase activity relationship: has_part GO:0047935 ! glucose 1-dehydrogenase (NADP+) activity created_by: dph creation_date: 2015-01-16T15:41:22Z [Term] id: GO:0061680 name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde namespace: biological_process def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde." [GOC:dph, MetaCyc:ENTNER-DOUDOROFF-PWY-II, PMID:12921536] xref: MetaCyc:ENTNER-DOUDOROFF-PWY-II is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate created_by: dph creation_date: 2015-01-22T08:51:31Z [Term] id: GO:0061681 name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate namespace: biological_process def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536] xref: MetaCyc:ENTNER-DOUDOROFF-PWY-III is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate relationship: has_part GO:0008673 ! 2-dehydro-3-deoxygluconokinase activity created_by: dph creation_date: 2015-01-22T08:55:22Z [Term] id: GO:0061682 name: seminal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0061107 ! seminal vesicle development created_by: dph creation_date: 2015-03-04T13:33:49Z [Term] id: GO:0061683 name: branching involved in seminal vesicle morphogenesis namespace: biological_process def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376] synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph] synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph] synonym: "seminal vesicle branching" EXACT [GOC:dph] synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0061682 ! seminal vesicle morphogenesis relationship: part_of GO:0061108 ! seminal vesicle epithelium development relationship: part_of GO:0061682 ! seminal vesicle morphogenesis created_by: dph creation_date: 2015-03-04T13:39:47Z [Term] id: GO:0061684 name: chaperone-mediated autophagy namespace: biological_process def: "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281] synonym: "CASA" BROAD [PMID:23434281] synonym: "chaperone-assisted selective autophagy" EXACT [PMID:23434281] synonym: "CMA" BROAD [PMID:22743996] xref: Wikipedia:Chaperone-mediated_autophagy is_a: GO:0006914 ! autophagy is_a: GO:0030163 ! protein catabolic process relationship: has_part GO:0005102 ! signaling receptor binding relationship: has_part GO:0072321 ! chaperone-mediated protein transport created_by: dph creation_date: 2015-03-04T14:35:26Z [Term] id: GO:0061685 name: diphthine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: diphthine methyl ester + H2O <=> diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656] xref: EC:3.1.1.97 xref: RHEA:42656 is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: dph creation_date: 2015-03-04T16:00:21Z [Term] id: GO:0061686 name: hercynylcysteine sulfoxide synthase namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:28577] synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen relationship: part_of GO:0052699 ! ergothioneine biosynthetic process created_by: dph creation_date: 2015-03-06T15:08:51Z [Term] id: GO:0061687 name: detoxification of inorganic compound namespace: biological_process def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw] is_a: GO:0098754 ! detoxification created_by: dph creation_date: 2015-03-09T09:16:23Z [Term] id: GO:0061688 name: glycolytic process via Entner-Doudoroff Pathway namespace: biological_process def: "A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes." [GOC:dph, PMID:9657988] synonym: "gluconate pathway" RELATED [] is_a: GO:0006096 ! glycolytic process created_by: dph creation_date: 2015-03-12T14:39:00Z [Term] id: GO:0061689 name: tricellular tight junction namespace: cellular_component def: "An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet." [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906] is_a: GO:0070160 ! tight junction created_by: dph creation_date: 2015-04-12T10:34:19Z [Term] id: GO:0061690 name: lipoamidase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein." [GOC:dph, PMID:14086741] synonym: "lipoyl-X-hydrolase" EXACT [PMID:14086741] xref: MetaCyc:RXN-13031 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: dph creation_date: 2015-05-05T10:06:49Z [Term] id: GO:0061691 name: detoxification of hydrogen peroxide namespace: biological_process def: "Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph] is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:0042542 ! response to hydrogen peroxide created_by: dph creation_date: 2015-05-05T12:42:18Z [Term] id: GO:0061692 name: cellular detoxification of hydrogen peroxide namespace: biological_process def: "Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph, GOC:vw] is_a: GO:0061691 ! detoxification of hydrogen peroxide is_a: GO:0098869 ! cellular oxidant detoxification relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide created_by: dph creation_date: 2015-05-05T12:46:20Z [Term] id: GO:0061693 name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine." [EC:2.7.8.37, GOC:dph, PMID:22089136] xref: EC:2.7.8.37 xref: MetaCyc:RXN0-6732 xref: RHEA:34679 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups created_by: dph creation_date: 2015-05-06T10:04:04Z [Term] id: GO:0061694 name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex namespace: cellular_component def: "A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity." [GOC:dph, PMID:22089136] comment: An example of this complex is PhnI (P16687) in Escherichia coli. is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: dph creation_date: 2015-05-06T10:12:02Z [Term] id: GO:0061695 name: transferase complex, transferring phosphorus-containing groups namespace: cellular_component def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] is_a: GO:1990234 ! transferase complex created_by: dph creation_date: 2015-05-06T11:22:38Z [Term] id: GO:0061696 name: pituitary gonadotropin complex namespace: cellular_component def: "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." [GOC:dph, PMID:11420129] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005576 ! extracellular region created_by: dph creation_date: 2015-05-06T13:11:18Z [Term] id: GO:0061697 name: protein-glutaryllysine deglutarylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:dph, PMID:24703693] comment: This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide. xref: RHEA:47664 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides relationship: part_of GO:0061699 ! peptidyl-lysine deglutarylation created_by: dph creation_date: 2015-05-07T10:55:53Z [Term] id: GO:0061698 name: protein deglutarylation namespace: biological_process def: "The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:dph, PMID:24703693] is_a: GO:0035601 ! protein deacylation created_by: dph creation_date: 2015-05-07T11:02:31Z [Term] id: GO:0061699 name: peptidyl-lysine deglutarylation namespace: biological_process def: "The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein." [GOC:dph, PMID:24703693] is_a: GO:0061698 ! protein deglutarylation created_by: dph creation_date: 2015-05-07T11:04:42Z [Term] id: GO:0061700 name: GATOR2 complex namespace: cellular_component def: "A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13." [GOC:rb, PMID:23723238] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0035859 ! Seh1-associated complex created_by: dph creation_date: 2015-05-07T11:13:27Z [Term] id: GO:0061701 name: bacterial outer membrane vesicle namespace: cellular_component def: "A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes." [GOC:dph, GOC:pr, PMID:20596524] is_a: GO:1903561 ! extracellular vesicle created_by: dph creation_date: 2015-05-07T13:53:47Z [Term] id: GO:0061702 name: inflammasome complex namespace: cellular_component def: "A cytosolic protein complex that is capable of activating caspase-1." [GOC:dph, PMID:17599095] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: dph creation_date: 2015-05-08T14:30:54Z [Term] id: GO:0061703 name: pyroptosome complex namespace: cellular_component def: "A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis." [GOC:dph, PMID:17599095] synonym: "ASC pyroptosome" EXACT [PMID:17599095] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2015-05-08T14:43:37Z [Term] id: GO:0061704 name: glycolytic process from sucrose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, PMID:15012287] is_a: GO:0005987 ! sucrose catabolic process is_a: GO:0006096 ! glycolytic process created_by: dph creation_date: 2015-06-11T13:26:28Z [Term] id: GO:0061705 name: sucrose catabolic process to fructose-6-phosphate through glucose and fructose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-621, PMID:15012287] xref: MetaCyc:PWY-621 is_a: GO:0005987 ! sucrose catabolic process relationship: has_part GO:0004340 ! glucokinase activity relationship: has_part GO:0008865 ! fructokinase activity created_by: dph creation_date: 2015-06-11T13:32:05Z [Term] id: GO:0061706 name: glycolytic process from sucrose through glucose and fructose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-1042, PMID:15012287] xref: MetaCyc:PWY-1042 is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate is_a: GO:0061704 ! glycolytic process from sucrose created_by: dph creation_date: 2015-06-11T13:40:32Z [Term] id: GO:0061707 name: extracellular exosome macropinocytosis namespace: biological_process def: "The single-organism macropinocytosis process that results in the uptake of an extracellular exosome." [GOC:dph, PMID:24951588] is_a: GO:0044351 ! macropinocytosis is_a: GO:0051650 ! establishment of vesicle localization created_by: dph creation_date: 2015-06-15T16:02:38Z [Term] id: GO:0061708 name: tRNA-5-taurinomethyluridine 2-sulfurtransferase namespace: molecular_function def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579] xref: MetaCyc:RXN-16821 xref: Reactome:R-HSA-6787447 "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA" is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: dph creation_date: 2015-06-16T09:02:23Z [Term] id: GO:0061709 name: reticulophagy namespace: biological_process alt_id: GO:1990766 def: "The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717] synonym: "autophagy of the endoplasmic reticulum" EXACT [] synonym: "autophagy of the ER" EXACT [] synonym: "endoplasmic reticulum degradation" RELATED [] synonym: "ER degradation" RELATED [] synonym: "ER-phagy" EXACT [] is_a: GO:0061912 ! selective autophagy is_a: GO:1903008 ! organelle disassembly relationship: has_part GO:1905692 ! endoplasmic reticulum disassembly created_by: dph creation_date: 2015-06-18T15:15:48Z [Term] id: GO:0061710 name: L-threonylcarbamoyladenylate synthase namespace: molecular_function def: "Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O." [EC:2.7.7.87] xref: EC:2.7.7.87 xref: MetaCyc:RXN-14569 xref: RHEA:36407 is_a: GO:0016779 ! nucleotidyltransferase activity created_by: dph creation_date: 2015-06-23T08:25:14Z [Term] id: GO:0061711 name: N(6)-L-threonylcarbamoyladenine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA." [EC:2.3.1.234] xref: EC:2.3.1.234 xref: MetaCyc:RXN-14570 xref: Reactome:R-HSA-6784494 "EKC complex threonylcarbamoylates A37 of tRNAs" xref: RHEA:37059 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: dph creation_date: 2015-06-23T08:34:44Z [Term] id: GO:0061712 name: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase namespace: molecular_function def: "Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine." [EC:2.8.4.5] xref: EC:2.8.4.5 xref: MetaCyc:RXN-14531 xref: RHEA:37075 is_a: GO:0035596 ! methylthiotransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: dph creation_date: 2015-06-23T08:47:10Z [Term] id: GO:0061713 name: anterior neural tube closure namespace: biological_process def: "The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline." [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298] is_a: GO:0060606 ! tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: dph creation_date: 2015-06-23T10:13:41Z [Term] id: GO:0061714 name: folic acid receptor activity namespace: molecular_function def: "Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis." [GOC:BHF, GOC:hal] synonym: "folate receptor activity" EXACT [] is_a: GO:0038024 ! cargo receptor activity relationship: has_part GO:0005542 ! folic acid binding relationship: part_of GO:0015884 ! folic acid transport relationship: part_of GO:0071231 ! cellular response to folic acid created_by: dph creation_date: 2015-06-23T13:36:07Z [Term] id: GO:0061715 name: miRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20705645] is_a: GO:0001510 ! RNA methylation is_a: GO:0010586 ! miRNA metabolic process created_by: dph creation_date: 2015-06-29T08:41:03Z [Term] id: GO:0061716 name: miRNA export from nucleus namespace: biological_process def: "The directed movement of a processed miRNA from the nucleus to the cytoplasm." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756] is_a: GO:0097064 ! ncRNA export from nucleus is_a: GO:1990428 ! miRNA transport created_by: dph creation_date: 2015-06-29T08:54:41Z [Term] id: GO:0061718 name: glucose catabolic process to pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph] synonym: "glucose catabolism to pyruvate" EXACT [GOC:dph] is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006090 ! pyruvate metabolic process created_by: dph creation_date: 2015-06-30T13:17:26Z [Term] id: GO:0061719 name: glucose catabolic process to pyruvate utilizing ADP namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions." [GOC:dph, MetaCyc:P341-PWY] xref: MetaCyc:P341-PWY is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0061718 ! glucose catabolic process to pyruvate relationship: has_part GO:0004332 ! fructose-bisphosphate aldolase activity relationship: has_part GO:0004347 ! glucose-6-phosphate isomerase activity relationship: has_part GO:0004618 ! phosphoglycerate kinase activity relationship: has_part GO:0004619 ! phosphoglycerate mutase activity relationship: has_part GO:0004807 ! triose-phosphate isomerase activity relationship: has_part GO:0043797 ! glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity relationship: has_part GO:0043844 ! ADP-specific phosphofructokinase activity created_by: dph creation_date: 2015-06-30T13:23:42Z [Term] id: GO:0061720 name: 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)." [GOC:dph, PMID:24463506] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process relationship: has_part GO:0061594 ! 6-deoxy-6-sulfofructose kinase activity created_by: dph creation_date: 2015-07-01T08:47:30Z [Term] id: GO:0061721 name: 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-) namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-)." [GOC:dph, PMID:14602517, PMID:24463506] xref: MetaCyc:PWY-7446 is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:0051143 ! propanediol metabolic process is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process created_by: dph creation_date: 2015-07-01T09:20:08Z [Term] id: GO:0061722 name: sulphoglycolysis namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate." [GOC:dph, PMID:24463506] synonym: "sulfoglycolysis" EXACT [PMID:14602597] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019674 ! NAD metabolic process is_a: GO:0046034 ! ATP metabolic process is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process relationship: has_part GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity relationship: has_part GO:0004618 ! phosphoglycerate kinase activity relationship: has_part GO:0004619 ! phosphoglycerate mutase activity relationship: has_part GO:0004634 ! phosphopyruvate hydratase activity relationship: has_part GO:0004807 ! triose-phosphate isomerase activity created_by: dph creation_date: 2015-07-01T09:44:30Z [Term] id: GO:0061723 name: glycophagy namespace: biological_process def: "The selective autophagy process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:21893048] is_a: GO:0005980 ! glycogen catabolic process is_a: GO:0061912 ! selective autophagy created_by: dph creation_date: 2015-07-08T13:36:51Z [Term] id: GO:0061724 name: lipophagy namespace: biological_process def: "The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:23708524, PMID:26076903] is_a: GO:0061912 ! selective autophagy relationship: has_part GO:1905691 ! lipid droplet disassembly created_by: dph creation_date: 2015-07-08T13:38:19Z [Term] id: GO:0061725 name: cytosolic lipolysis namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy] is_a: GO:0044242 ! cellular lipid catabolic process relationship: occurs_in GO:0005829 ! cytosol created_by: dph creation_date: 2015-07-08T13:42:15Z [Term] id: GO:0061726 name: mitochondrion disassembly namespace: biological_process def: "The disaggregation of a mitochondrion into its constituent components." [GOC:autophagy, PMID:25009776] synonym: "mitochondrion degradation" EXACT [GOC:autophagy] is_a: GO:0007005 ! mitochondrion organization is_a: GO:1903008 ! organelle disassembly created_by: dph creation_date: 2015-07-08T13:59:16Z [Term] id: GO:0061727 name: methylglyoxal catabolic process to lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." [GOC:dph, PMID:2198020] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0051596 ! methylglyoxal catabolic process created_by: dph creation_date: 2015-07-21T17:25:57Z [Term] id: GO:0061728 name: GDP-mannose biosynthetic process from mannose namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose." [GOC:dph, PMID:16339137, PMID:24218558] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0009298 ! GDP-mannose biosynthetic process created_by: dph creation_date: 2015-07-24T14:44:04Z [Term] id: GO:0061729 name: GDP-mannose biosynthetic process from fructose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate." [GOC:dph, PMID:16339137] xref: Reactome:R-HSA-446205 "Synthesis of GDP-mannose, Homo sapiens" is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0009298 ! GDP-mannose biosynthetic process is_a: GO:0019637 ! organophosphate metabolic process created_by: dph creation_date: 2015-07-24T14:50:44Z [Term] id: GO:0061730 name: C-rich strand telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with C-rich, single-stranded, telomere-associated DNA." [GOC:dph, GOC:kmv, PMID:18329362] is_a: GO:0043047 ! single-stranded telomeric DNA binding created_by: dph creation_date: 2015-08-20T09:08:27Z [Term] id: GO:0061731 name: ribonucleoside-diphosphate reductase activity namespace: molecular_function def: "Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [GOC:dph, GOC:vw, PMID:16756507] synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [] synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [] synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [] synonym: "class I ribonucleotide reductase activity" RELATED [] synonym: "class II ribonucleoside-diphosphate reductase activity" RELATED [] synonym: "class II ribonucleotide reductase activity" RELATED [] synonym: "class III ribonucleotide reductase activity" RELATED [] synonym: "nucleoside diphosphate reductase activity" RELATED [] synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [] synonym: "ribonucleotide diphosphate reductase activity" EXACT [] synonym: "ribonucleotide reductase activity" BROAD [] synonym: "RNR" RELATED [] is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor created_by: dph creation_date: 2015-08-24T07:25:59Z [Term] id: GO:0061732 name: mitochondrial acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA." [GOC:dph, ISBN:0201090910] xref: Reactome:R-HSA-372342.1 xref: Reactome:R-HSA-71397.1 is_a: GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate created_by: dph creation_date: 2015-08-24T13:44:02Z [Term] id: GO:0061733 name: peptide-lysine-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide." [GOC:dph] xref: Reactome:R-HSA-6811508 "ING2-bound EP300 acetylates TP53" xref: Reactome:R-HSA-8951966 "EP300 acetylates RUNX3" xref: Reactome:R-HSA-9617758 "EP300,CREBBP acetylate FOXO4" xref: Reactome:R-HSA-9620515 "KAT2B,EP300 acetylate FOXO3 under oxidative stress" xref: Reactome:R-HSA-9626945 "CREBBP acetylates FOXO1" is_a: GO:0034212 ! peptide N-acetyltransferase activity created_by: dph creation_date: 2015-09-10T10:22:19Z [Term] id: GO:0061734 name: parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190] synonym: "Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] synonym: "PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] is_a: GO:0098779 ! positive regulation of mitophagy in response to mitochondrial depolarization created_by: dph creation_date: 2015-09-14T13:48:57Z [Term] id: GO:0061735 name: DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190] synonym: "dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] is_a: GO:0098779 ! positive regulation of mitophagy in response to mitochondrial depolarization created_by: dph creation_date: 2015-09-14T14:00:43Z [Term] id: GO:0061736 name: engulfment of target by autophagosome namespace: biological_process def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] is_a: GO:0010324 ! membrane invagination intersection_of: GO:0010324 ! membrane invagination intersection_of: part_of GO:0000045 ! autophagosome assembly relationship: part_of GO:0000045 ! autophagosome assembly created_by: dph creation_date: 2015-09-14T14:10:24Z [Term] id: GO:0061737 name: leukotriene signaling pathway namespace: biological_process def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:21771892] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: dph creation_date: 2015-09-15T12:58:21Z [Term] id: GO:0061738 name: late endosomal microautophagy namespace: biological_process def: "The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931] is_a: GO:0006914 ! autophagy created_by: dph creation_date: 2015-09-24T14:40:02Z [Term] id: GO:0061739 name: protein lipidation involved in autophagosome assembly namespace: biological_process def: "The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly." [GOC:autophagy, GOC:dph, PMID:11096062, PMID:11100732, PMID:15277523] is_a: GO:0006501 ! C-terminal protein lipidation intersection_of: GO:0006501 ! C-terminal protein lipidation intersection_of: part_of GO:0000045 ! autophagosome assembly relationship: has_part GO:0019779 ! Atg8 activating enzyme activity relationship: part_of GO:0000045 ! autophagosome assembly created_by: dph creation_date: 2015-10-14T12:02:01Z [Term] id: GO:0061740 name: protein targeting to lysosome involved in chaperone-mediated autophagy namespace: biological_process def: "The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor." [GOC:dph, GOC:pad, GOC:PARL, PMID:22748206] is_a: GO:0006622 ! protein targeting to lysosome is_a: GO:0071211 ! protein targeting to vacuole involved in autophagy intersection_of: GO:0006622 ! protein targeting to lysosome intersection_of: part_of GO:0061684 ! chaperone-mediated autophagy relationship: has_part GO:0005102 ! signaling receptor binding relationship: has_part GO:0051087 ! chaperone binding relationship: part_of GO:0061684 ! chaperone-mediated autophagy created_by: dph creation_date: 2015-10-21T08:41:29Z [Term] id: GO:0061741 name: chaperone-mediated protein transport involved in chaperone-mediated autophagy namespace: biological_process def: "The chaperone-mediated protein transport process in which a protein that is bound to a chaperone and a lysosomal receptor is unfolded and transported into the lysosome as part of chaperone-mediated autophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:22748206] is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072321 ! chaperone-mediated protein transport intersection_of: GO:0072321 ! chaperone-mediated protein transport intersection_of: part_of GO:0061684 ! chaperone-mediated autophagy relationship: has_part GO:0043335 ! protein unfolding relationship: part_of GO:0061684 ! chaperone-mediated autophagy created_by: dph creation_date: 2015-10-21T08:56:33Z [Term] id: GO:0061742 name: chaperone-mediated autophagy translocation complex namespace: cellular_component def: "A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy." [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626] synonym: "chaperone-mediated autophagy receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL] synonym: "CMA receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL] synonym: "CMA translocation complex" EXACT [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005765 ! lysosomal membrane created_by: dph creation_date: 2015-10-23T07:39:04Z [Term] id: GO:0061743 name: motor learning namespace: biological_process def: "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience." [GOC:bf, GOC:PARL, Wikipedia:Motor_learning] is_a: GO:0007612 ! learning created_by: dph creation_date: 2015-11-09T12:40:29Z [Term] id: GO:0061744 name: motor behavior namespace: biological_process def: "The specific neuromuscular movement of a single organism in response to external or internal stimuli." [GOC:bf, GOC:PARL, PMID:25318560] is_a: GO:0007610 ! behavior created_by: dph creation_date: 2015-11-09T12:43:11Z [Term] id: GO:0061745 name: GTPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction directly drives some other reaction." [GOC:dph, PMID:26277776] is_a: GO:0003924 ! GTPase activity created_by: dph creation_date: 2015-11-11T12:47:56Z [Term] id: GO:0061746 name: single-stranded DNA-dependent GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776] is_a: GO:0061745 ! GTPase activity, coupled created_by: dph creation_date: 2015-11-11T12:50:19Z [Term] id: GO:0061747 name: CTPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate; this reaction directly drives some other reaction." [GOC:dph, PMID:26277776] is_a: GO:0043273 ! CTPase activity created_by: dph creation_date: 2015-11-11T13:02:49Z [Term] id: GO:0061748 name: single-stranded DNA-dependent CTPase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776] is_a: GO:0061747 ! CTPase activity, coupled created_by: dph creation_date: 2015-11-11T13:05:32Z [Term] id: GO:0061749 name: forked DNA-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA helix containing forked DNA." [GOC:dph, PMID:26277776] is_a: GO:0003678 ! DNA helicase activity created_by: dph creation_date: 2015-11-11T13:10:51Z [Term] id: GO:0061750 name: acid sphingomyelin phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment." [GOC:dph, PMID:26493087] synonym: "acid SMase" RELATED [PMID:26493087] synonym: "acid sphingomyelinase" EXACT [PMID:26493087] is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity created_by: dph creation_date: 2015-11-11T14:47:45Z [Term] id: GO:0061751 name: neutral sphingomyelin phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in a neutral environment." [GOC:dph, PMID:26493087] synonym: "neutral SMase" EXACT [PMID:26493087] synonym: "neutral sphingomyelinase" EXACT [GOC:26493087] is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity created_by: dph creation_date: 2015-11-11T14:48:08Z [Term] id: GO:0061752 name: telomeric repeat-containing RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats." [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916] synonym: "TERRA binding" EXACT [PMID:20655916] is_a: GO:0003723 ! RNA binding created_by: dph creation_date: 2015-11-13T07:55:06Z [Term] id: GO:0061753 name: substrate localization to autophagosome namespace: biological_process def: "The localization process by which an autophagic substrate is delivered to a forming autophagosome." [GOC:dph, GOC:pad, GOC:PARL, PMID:23545414] synonym: "substrate sequestration to autophagosome" EXACT [] synonym: "substrate sequestration to phagophore" EXACT [] is_a: GO:0051649 ! establishment of localization in cell relationship: part_of GO:0000045 ! autophagosome assembly created_by: dph creation_date: 2015-11-20T11:14:22Z [Term] id: GO:0061754 name: negative regulation of circulating fibrinogen levels namespace: biological_process def: "Any process that reduces the quantity of fibrinogen circulating in the bloodstream." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20570858] is_a: GO:0044537 ! regulation of circulating fibrinogen levels created_by: dph creation_date: 2016-02-29T16:19:09Z [Term] id: GO:0061755 name: positive regulation of circulating fibrinogen levels namespace: biological_process def: "Any process that increases the quantity of fibrinogen circulating in the bloodstream." [GOC:bf, GOC:BHF, GOC:BHF_miRNA, PMID:20570858] is_a: GO:0044537 ! regulation of circulating fibrinogen levels created_by: dph creation_date: 2016-02-29T16:26:49Z [Term] id: GO:0061756 name: leukocyte adhesion to vascular endothelial cell namespace: biological_process def: "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866] is_a: GO:0007159 ! leukocyte cell-cell adhesion created_by: dph creation_date: 2016-02-29T16:42:11Z [Term] id: GO:0061757 name: leukocyte adhesion to arterial endothelial cell namespace: biological_process def: "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480] is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell created_by: dph creation_date: 2016-02-29T16:49:38Z [Term] id: GO:0061758 name: 2-hydroxyglutarate dehydrogenase activity, forward reaction namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, GOC:dph, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] synonym: "alpha-ketoglutarate reductase activity, reverse reaction" EXACT [GOC:dph] xref: RHEA:21253 is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity created_by: dph creation_date: 2016-03-07T08:28:58Z [Term] id: GO:0061759 name: alpha-ketoglutarate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + reduced acceptor -> (S)-2-hydroxyglutarate + acceptor." [EC:1.1.99.2, GOC:dph, PMID:26774271] synonym: "2-hydroxyglutarate dehydrogenase activity, reverse reaction" EXACT [GOC:dph] synonym: "2-ketoglutarate reductase activity" RELATED [GOC:dph] synonym: "2-oxoglutarate reductase activity" RELATED [GOC:dph] synonym: "D-2HG reductase activity" RELATED [GOC:dph] xref: RHEA:21254 is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity created_by: dph creation_date: 2016-03-07T08:38:57Z [Term] id: GO:0061760 name: antifungal innate immune response namespace: biological_process def: "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:dph, PMID:22470487] is_a: GO:0045087 ! innate immune response is_a: GO:0050832 ! defense response to fungus created_by: dph creation_date: 2016-03-07T08:53:08Z [Term] id: GO:0061761 name: alpha-latrotoxin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-latrotoxin receptor." [GOC:dph, PMID:21724987] synonym: "lasso receptor binding" EXACT [GOC:dph, PMID:21724987] synonym: "latrophilin binding" EXACT [GOC:dph, PMID:21724987] is_a: GO:0001664 ! G protein-coupled receptor binding created_by: dph creation_date: 2016-04-13T10:46:42Z [Term] id: GO:0061762 name: CAMKK-AMPK signaling cascade namespace: biological_process def: "A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity." [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372] synonym: "stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:dph] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0099004 ! calmodulin dependent kinase signaling pathway relationship: has_part GO:0005516 ! calmodulin binding created_by: dph creation_date: 2016-04-14T12:59:31Z [Term] id: GO:0061763 name: multivesicular body-lysosome fusion namespace: biological_process def: "The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle." [GOC:dph, GOC:pad, GOC:PARL, PMID:21118109] synonym: "fusion of multivesicular body to lysosome" EXACT [GOC:dph] synonym: "fusion of MVB to lysosome" EXACT [GOC:dph] synonym: "MVB-lysosome fusion" EXACT [GOC:dph] is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway created_by: dph creation_date: 2016-04-15T07:12:40Z [Term] id: GO:0061764 name: late endosome to lysosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:dph] is_a: GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway is_a: GO:0045324 ! late endosome to vacuole transport is_a: GO:1902774 ! late endosome to lysosome transport created_by: dph creation_date: 2016-04-19T09:29:57Z [Term] id: GO:0061765 name: modulation by virus of host NIK/NF-kappaB signaling namespace: biological_process def: "Any process in which a virus effect a change in the frequency, rate or extent of NIK/NF-kappaB signaling in the host." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:26764146] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling created_by: dph creation_date: 2016-04-19T10:41:22Z [Term] id: GO:0061766 name: positive regulation of lung blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22161164] synonym: "positive regulation of pulmonary blood pressure" EXACT [GOC:dph] is_a: GO:0014916 ! regulation of lung blood pressure created_by: dph creation_date: 2016-04-27T11:54:34Z [Term] id: GO:0061767 name: negative regulation of lung blood pressure namespace: biological_process def: "The process that decreases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:dph, PMID:22161164] synonym: "negative regulation of pulmonary blood pressure" EXACT [GOC:dph] is_a: GO:0014916 ! regulation of lung blood pressure created_by: dph creation_date: 2016-04-27T11:58:55Z [Term] id: GO:0061768 name: magnesium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)." [GOC:pad, GOC:PARL, PMID:22031603] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity created_by: dph creation_date: 2016-05-04T14:45:45Z [Term] id: GO:0061769 name: ribosylnicotinate kinase activity namespace: molecular_function def: "Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H(+) + nicotinate mononucleotide." [GOC:dph, PMID:17914902] xref: Reactome:R-HSA-8869606 "NMRK1 phosphorylates NAR to yield NAMN" xref: Reactome:R-HSA-8869607 "NMRK2 phosphorylates NAR to yield NAMN" is_a: GO:0016301 ! kinase activity created_by: dph creation_date: 2016-05-05T14:41:44Z [Term] id: GO:0061770 name: translation elongation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation." [GOC:dph] is_a: GO:0005515 ! protein binding created_by: dph creation_date: 2016-07-09T09:31:11Z [Term] id: GO:0061771 name: response to caloric restriction namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake." [GOC:dph, PMID:15520862] is_a: GO:0006950 ! response to stress is_a: GO:0031667 ! response to nutrient levels created_by: dph creation_date: 2016-07-09T09:40:32Z [Term] id: GO:0061772 name: xenobiotic transport across blood-nerve barrier namespace: biological_process def: "The directed movement of a xenobiotic through the blood-nerve barrier." [GOC:dph, PMID:22733753] synonym: "drug transport across blood-nerve barrier" RELATED [] synonym: "drug transport across perineurial barrier" EXACT [PMID:22733753] is_a: GO:0042908 ! xenobiotic transport created_by: dph creation_date: 2016-07-09T09:59:59Z [Term] id: GO:0061773 name: eNoSc complex namespace: cellular_component def: "A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation." [GOC:BHM, Intact:EBI-11789632, Intact:EBI-11790279, PMID:18485871] synonym: "energy dependent nucleolar silencing complex" EXACT [] is_a: GO:0005677 ! chromatin silencing complex relationship: part_of GO:0005730 ! nucleolus created_by: dph creation_date: 2016-07-09T10:12:30Z [Term] id: GO:0061774 name: cohesin unloading namespace: biological_process def: "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA." [GOC:dph, GOC:vw, PMID:26687354] synonym: "DNA exit from the cohesin ring" EXACT [GOC:dph, GOC:vw] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:0045875 ! negative regulation of sister chromatid cohesion created_by: dph creation_date: 2016-07-13T12:40:25Z [Term] id: GO:0061775 name: cohesin ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, coupled to the topological linking or unlinking of a cohesin ring complex around homologous chromosomes.'" [GOC:dph, GOC:vw, PMID:26687354] is_a: GO:0008094 ! DNA-dependent ATPase activity created_by: dph creation_date: 2016-07-13T12:54:43Z [Term] id: GO:0061776 name: topological DNA entrapment activity namespace: molecular_function def: "The DNA binding activity by which a protein complex interacts selectively and non-covalently with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring." [GOC:dph, GOC:vw, PMID:16179255, PMID:26687354, PMID:27797071] is_a: GO:0003690 ! double-stranded DNA binding created_by: dph creation_date: 2016-07-13T13:10:15Z [Term] id: GO:0061777 name: obsolete DNA clamp activity namespace: molecular_function def: "OBSOLETE. A DNA binding activity in which a protein complex interacts selectively and non-covalently with single DNA duplex to tightly encircle the DNA." [GOC:dph, GOC:vw, PMID:1349852] comment: The reason for obsoletion is that the term captures the structure of a complex, not a specific function. is_obsolete: true created_by: dph creation_date: 2016-07-13T13:15:24Z [Term] id: GO:0061778 name: intracellular chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:dph, PMID:23092411] is_a: GO:0005254 ! chloride channel activity created_by: dph creation_date: 2016-08-02T09:37:15Z [Term] id: GO:0061779 name: Tapasin-ERp57 complex namespace: cellular_component def: "Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role." [GOC:bhm, GOC:dph, Intact:EBI-11896237, Intact:EBI-9013963, PMID:17603487] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0042824 ! MHC class I peptide loading complex created_by: dph creation_date: 2016-08-05T12:12:08Z [Term] id: GO:0061780 name: mitotic cohesin loading namespace: biological_process def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:vw] is_a: GO:0071921 ! cohesin loading intersection_of: GO:0071921 ! cohesin loading intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0034087 ! establishment of mitotic sister chromatid cohesion created_by: dph creation_date: 2016-08-23T13:00:34Z [Term] id: GO:0061781 name: mitotic cohesin unloading namespace: biological_process def: "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:vw] is_a: GO:0061774 ! cohesin unloading intersection_of: GO:0061774 ! cohesin unloading intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle created_by: dph creation_date: 2016-08-24T09:43:07Z [Term] id: GO:0061782 name: vesicle fusion with vesicle namespace: biological_process def: "Fusion of the membrane of a transport vesicle with a target membrane on another vesicle." [GOC:bf, GOC:PARL, PMID:16618809] synonym: "vesicle to vesicle fusion" EXACT [GOC:dph] synonym: "vesicle-vesicle fusion" EXACT [GOC:dph] is_a: GO:0006906 ! vesicle fusion created_by: dph creation_date: 2016-09-06T13:29:49Z [Term] id: GO:0061783 name: peptidoglycan muralytic activity namespace: molecular_function def: "A catalytic activity that contributes to the degradation of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] is_a: GO:0003824 ! catalytic activity created_by: dph creation_date: 2016-09-07T15:47:49Z [Term] id: GO:0061784 name: peptidoglycan N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] is_a: GO:0015929 ! hexosaminidase activity is_a: GO:0061783 ! peptidoglycan muralytic activity created_by: dph creation_date: 2016-09-07T16:17:03Z [Term] id: GO:0061785 name: peptidoglycan endopeptidase activity namespace: molecular_function def: "An endopeptidase activity that uses peptidoglycan as a substrate." [GOC:dph, GOC:jh, PMID:22748813] is_a: GO:0004175 ! endopeptidase activity is_a: GO:0061783 ! peptidoglycan muralytic activity created_by: dph creation_date: 2016-09-07T16:30:48Z [Term] id: GO:0061786 name: peptidoglycan stem peptide endopeptidase activity namespace: molecular_function def: "A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] is_a: GO:0061785 ! peptidoglycan endopeptidase activity created_by: dph creation_date: 2016-09-07T16:47:04Z [Term] id: GO:0061787 name: peptidoglycan cross-bridge peptide endopeptidase activity namespace: molecular_function def: "A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge." [GOC:dph, GOC:jh, PMID:22748813] synonym: "lysostaphin activity" NARROW [GOC:dph, GOC:jh, PMID:22748813] is_a: GO:0061785 ! peptidoglycan endopeptidase activity created_by: dph creation_date: 2016-09-07T16:54:02Z [Term] id: GO:0061788 name: EGF repeat binding namespace: molecular_function def: "Interacting selectively and non-covalently with Epidermal Growth Factor (EGF) repeats." [GOC:25700513, GOC:dph, PMID:25155514] synonym: "Epidermal growth factor domain binding" BROAD [GOC:dph] synonym: "Epidermal Growth Factor repeat binding" RELATED [GOC:dph] is_a: GO:0019904 ! protein domain specific binding created_by: dph creation_date: 2016-09-08T15:22:28Z [Term] id: GO:0061789 name: dense core granule priming namespace: biological_process def: "A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking." [GOC:bf, GOC:PARL, PMID:10899113, PMID:26575293] synonym: "dense core vesicle priming" EXACT [PMID:26575293] synonym: "large dense-core vesicle priming" EXACT [PMID:10899113] synonym: "LDCV priming" EXACT [PMID:26575293] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0140029 ! exocytic process relationship: part_of GO:1990504 ! dense core granule exocytosis created_by: dph creation_date: 2016-09-08T15:41:30Z [Term] id: GO:0061790 name: dense core granule docking namespace: biological_process def: "The initial attachment of a dense core granule membrane to the plasma membrane." [GOC:bf, GOC:PARL, PMID:26575293] is_a: GO:0006904 ! vesicle docking involved in exocytosis intersection_of: GO:0048278 ! vesicle docking intersection_of: part_of GO:1990504 ! dense core granule exocytosis relationship: part_of GO:1990504 ! dense core granule exocytosis created_by: dph creation_date: 2016-09-08T15:51:49Z [Term] id: GO:0061791 name: GTPase motor activity namespace: molecular_function def: "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of GTP." [GOC:dph, GOC:vw] is_a: GO:0003774 ! motor activity is_a: GO:0003924 ! GTPase activity created_by: dph creation_date: 2016-09-09T13:17:29Z [Term] id: GO:0061792 name: secretory granule maturation namespace: biological_process def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] is_a: GO:0021700 ! developmental maturation is_a: GO:0033363 ! secretory granule organization created_by: dph creation_date: 2016-09-09T13:24:34Z [Term] id: GO:0061793 name: chromatin lock complex namespace: cellular_component def: "A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping." [GOC:bhm, GOC:dph, PMID:17540172] synonym: "nucleosome bridging complex" RELATED [GOC:dph] xref: IntAct:EBI-11790939 xref: IntAct:EBI-11792170 is_a: GO:0005677 ! chromatin silencing complex created_by: dph creation_date: 2016-09-09T13:47:27Z [Term] id: GO:0061794 name: conidium development namespace: biological_process def: "The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:dph] is_a: GO:0048468 ! cell development created_by: dph creation_date: 2016-09-17T09:53:51Z [Term] id: GO:0061795 name: Golgi lumen acidification namespace: biological_process def: "Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion." [GOC:dph, PMID:23447592] is_a: GO:0051452 ! intracellular pH reduction created_by: dph creation_date: 2016-10-05T08:42:40Z [Term] id: GO:0061796 name: membrane addition at site of mitotic cytokinesis namespace: biological_process def: "A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:dph, GOC:vw] is_a: GO:0007107 ! membrane addition at site of cytokinesis is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0007107 ! membrane addition at site of cytokinesis intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: dph creation_date: 2016-10-05T12:06:11Z [Term] id: GO:0061797 name: pH-gated chloride channel activity namespace: molecular_function def: "A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH." [GOC:dph, PMID:27358471] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022836 ! gated channel activity created_by: dph creation_date: 2016-10-06T07:11:14Z [Term] id: GO:0061798 name: GTP 3',8'-cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate." [GOC:dph, GOC:ik, PMID:25896388] xref: EC:4.1.99.22 xref: MetaCyc:RXN-8340 is_a: GO:0016830 ! carbon-carbon lyase activity created_by: dph creation_date: 2016-10-06T14:26:11Z [Term] id: GO:0061799 name: cyclic pyranopterin monophosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388] xref: EC:4.6.1.17 xref: MetaCyc:RXN-17809 is_a: GO:0016849 ! phosphorus-oxygen lyase activity created_by: dph creation_date: 2016-10-06T14:36:56Z [Term] id: GO:0061800 name: fibronectin fibril namespace: cellular_component def: "A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks." [GOC:dph, PMID:20690820] is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0031012 ! extracellular matrix created_by: dph creation_date: 2016-10-24T14:04:21Z [Term] id: GO:0061801 name: laminin-5B complex namespace: cellular_component def: "A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains." [GOC:dph, PMID:15979864] synonym: "laminin 3B32 complex" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex created_by: dph creation_date: 2016-10-26T15:05:15Z [Term] id: GO:0061802 name: anterior cell cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis." [GOC:15666355, GOC:17981131, GOC:dph, GOC:kmv] is_a: GO:0099738 ! cell cortex region created_by: dph creation_date: 2016-11-06T22:54:21Z [Term] id: GO:0061803 name: posterior cell cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis." [GOC:dph, GOC:kmv, PMID:15666355, PMID:17981131] is_a: GO:0099738 ! cell cortex region created_by: dph creation_date: 2016-11-06T22:55:45Z [Term] id: GO:0061804 name: mitotic spindle formation (spindle phase one) namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase." [GOC:dph, GOC:vw, PMID:21920317] synonym: "mitotic spindle elongation during mitotic prophase" EXACT [] synonym: "mitotic spindle elongation during prophase" EXACT [] synonym: "mitotic spindle elongation during prophase and prometaphase" EXACT [] is_a: GO:0007052 ! mitotic spindle organization intersection_of: GO:0007051 ! spindle organization intersection_of: happens_during GO:0000088 ! mitotic prophase intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000088 ! mitotic prophase relationship: part_of GO:0000022 ! mitotic spindle elongation relationship: part_of GO:0090307 ! mitotic spindle assembly created_by: dph creation_date: 2016-11-06T23:08:01Z [Term] id: GO:0061805 name: mitotic spindle elongation (spindle phase three) namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B." [GOC:dph, GOC:vw, PMID:21920317] synonym: "mitotic anaphase spindle elongation" EXACT [] synonym: "mitotic spindle elongation during anaphase" EXACT [] synonym: "mitotic spindle elongation during mitotic anaphase" EXACT [] is_a: GO:0007052 ! mitotic spindle organization intersection_of: GO:0007051 ! spindle organization intersection_of: happens_during GO:0000092 ! mitotic anaphase B intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000092 ! mitotic anaphase B relationship: part_of GO:0000022 ! mitotic spindle elongation created_by: dph creation_date: 2016-11-06T23:09:43Z [Term] id: GO:0061806 name: regulation of DNA recombination at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA." [GOC:dph, GOC:mah, PMID:27697832] synonym: "regulation of centromeric recombination" EXACT [GOC:mah] is_a: GO:0000018 ! regulation of DNA recombination created_by: dph creation_date: 2016-11-10T15:17:11Z [Term] id: GO:0061807 name: positive regulation of DNA recombination at centromere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere." [GOC:dph, GOC:mah] synonym: "positive regulation of centromeric recombination" EXACT [GOC:mah] is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0061806 ! regulation of DNA recombination at centromere created_by: dph creation_date: 2016-11-10T15:20:04Z [Term] id: GO:0061808 name: negative regulation of DNA recombination at centromere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere." [GOC:dph, GOC:mah] synonym: "negative regulation of centromeric recombination" EXACT [GOC:dph] is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:0061806 ! regulation of DNA recombination at centromere created_by: dph creation_date: 2016-11-10T15:24:50Z [Term] id: GO:0061809 name: NAD+ nucleotidase, cyclic ADP-ribose generating namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] xref: EC:3.2.2.6 xref: MetaCyc:NADNUCLEOSID-RXN is_a: GO:0003953 ! NAD+ nucleosidase activity relationship: has_part GO:0061811 ! ADP-ribosyl cyclase activity relationship: has_part GO:0061812 ! cyclic ADP-ribose hydrolase created_by: dph creation_date: 2016-11-11T13:14:13Z [Term] id: GO:0061810 name: NAD glycohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] xref: EC:3.2.2.5 is_a: GO:0003953 ! NAD+ nucleosidase activity created_by: dph creation_date: 2016-11-11T13:18:54Z [Term] id: GO:0061811 name: ADP-ribosyl cyclase activity namespace: molecular_function def: "Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528] is_a: GO:0009975 ! cyclase activity created_by: dph creation_date: 2016-11-11T13:25:18Z [Term] id: GO:0061812 name: cyclic ADP-ribose hydrolase namespace: molecular_function def: "Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR)." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: dph creation_date: 2016-11-11T13:32:43Z [Term] id: GO:0061813 name: obsolete ARID domain binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a ARID domain. The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors." [GOC:dph, InterPro:IPR001606, PMID:18270511] is_obsolete: true created_by: dph creation_date: 2016-11-11T13:57:55Z [Term] id: GO:0061814 name: condensin I complex namespace: cellular_component def: "A condensin complex that associates with chromosomes after nuclear envelope breakdown." [GOC:dph, PMID:21795393] is_a: GO:0000796 ! condensin complex created_by: dph creation_date: 2016-11-23T10:34:33Z [Term] id: GO:0061815 name: ubiquitinyl hydrolase activity, acting on linear ubiquitin namespace: molecular_function def: "Catalysis of the hydrolysis of ubiquitin units from linear ubiquitin chains." [GOC:dph, PMID:26503766, PMID:27702987] synonym: "linear ubiquitin specific deubiquitinase activity" EXACT [] synonym: "Met1 linkage specific DUB" EXACT [] is_a: GO:0101005 ! ubiquitinyl hydrolase activity created_by: dph creation_date: 2016-11-28T13:58:44Z [Term] id: GO:0061816 name: proteaphagy namespace: biological_process def: "The selective autophagy process that clears 26S proteasomes; homeostatic mechanism within the ubiquitin system that modulates proteolytic capacity and eliminates damaged particles." [GOC:dph, GOC:se, PMID:26670610, PMID:27477278] is_a: GO:0035973 ! aggrephagy created_by: dph creation_date: 2016-12-01T20:21:28Z [Term] id: GO:0061817 name: endoplasmic reticulum-plasma membrane tethering namespace: biological_process def: "The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684] synonym: "ER-plasma membrane tethering" EXACT [GOC:dph] is_a: GO:0051643 ! endoplasmic reticulum localization is_a: GO:0140056 ! organelle localization by membrane tethering created_by: dph creation_date: 2016-12-05T14:43:58Z [Term] id: GO:0061818 name: tRNA folding namespace: biological_process def: "The process of assisting in the folding of tRNAs into the correct tertiary structure." [GOC:dph, PMID:27849601] is_a: GO:0034337 ! RNA folding created_by: dph creation_date: 2016-12-13T15:54:40Z [Term] id: GO:0061819 name: telomeric DNA-containing double minutes formation namespace: biological_process def: "A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:14690602, PMID:2397458] synonym: "TDMs formation" EXACT [] is_a: GO:0000722 ! telomere maintenance via recombination created_by: dph creation_date: 2016-12-20T09:49:03Z [Term] id: GO:0061820 name: telomeric D-loop disassembly namespace: biological_process def: "A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755] is_a: GO:0090657 ! telomeric loop disassembly created_by: dph [Term] id: GO:0061821 name: telomeric D-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19734539] synonym: "telomeric Displacement-loop binding" EXACT [] is_a: GO:0062037 ! D-loop DNA binding created_by: dph [Term] id: GO:0061822 name: ciliary cap namespace: cellular_component def: "An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole." [PMID:25447994, PMID:27646273] synonym: "spermatid ciliary cap" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium created_by: dph creation_date: 2017-01-14T14:14:11Z [Term] id: GO:0061823 name: ring centriole namespace: cellular_component def: "A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum." [PMID:25447994, PMID:4903810] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium created_by: dph creation_date: 2017-01-14T14:18:29Z [Term] id: GO:0061824 name: cytosolic ciliogenesis namespace: biological_process def: "The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm." [PMID:25447994, PMID:26654377] synonym: "intracellular ciliogenesis" RELATED [] is_a: GO:0060271 ! cilium assembly created_by: dph creation_date: 2017-01-14T14:24:17Z [Term] id: GO:0061825 name: podosome core namespace: cellular_component def: "The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [PMID:23158496] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0002102 ! podosome created_by: dph creation_date: 2017-01-14T14:42:45Z [Term] id: GO:0061826 name: podosome ring namespace: cellular_component def: "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0002102 ! podosome created_by: dph creation_date: 2017-01-14T14:44:53Z [Term] id: GO:0061827 name: sperm head namespace: cellular_component def: "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome." [PMID:22797892, PMID:24665388] is_a: GO:0110165 ! cellular anatomical entity created_by: dph creation_date: 2017-01-15T10:39:00Z [Term] id: GO:0061828 name: apical tubulobulbar complex namespace: cellular_component def: "Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [PMID:20403871, PMID:22510523] synonym: "apical TBC" EXACT [] is_a: GO:0036284 ! tubulobulbar complex created_by: dph creation_date: 2017-01-15T10:41:00Z [Term] id: GO:0061829 name: basal tubulobulbar complex namespace: cellular_component def: "Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell." [PMID:20403871, PMID:22510523] synonym: "basal TBC" EXACT [] is_a: GO:0036284 ! tubulobulbar complex created_by: dph creation_date: 2017-01-15T10:42:31Z [Term] id: GO:0061830 name: concave side of sperm head namespace: cellular_component def: "The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species." [PMID:22332112, PMID:23403943, PMID:26990065] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0061827 ! sperm head [Term] id: GO:0061831 name: apical ectoplasmic specialization namespace: cellular_component def: "Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604] synonym: "apical ES" EXACT [] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0061832 name: basal ectoplasmic specialization namespace: cellular_component def: "Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604] synonym: "basal ES" EXACT [] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0061833 name: protein localization to tricellular tight junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction." [PMID:24889144] is_a: GO:0150105 ! protein localization to cell-cell junction [Term] id: GO:0061834 name: actin filament branch point namespace: cellular_component def: "The part of an actin filament where the structure forks." [PMID:18256280] synonym: "microfilament branch point" EXACT [GOC:dph] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005884 ! actin filament [Term] id: GO:0061835 name: ventral surface of cell namespace: cellular_component def: "The surface of a migrating cell that is in contact with the substratum or cell layer." [PMID:11598004] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0061836 name: intranuclear rod namespace: cellular_component def: "A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions." [PMID:28074884] synonym: "intranuclear actin rod" EXACT [] is_a: GO:0099512 ! supramolecular fiber [Term] id: GO:0061837 name: neuropeptide processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide." [PMID:12657671, PMID:17564681] is_a: GO:0016485 ! protein processing [Term] id: GO:0061838 name: CENP-T-W-S-X complex namespace: cellular_component def: "A histone-variant containing protein complex which forms a centromere specific nucleosomal structure, involved in centromeric chromatin organization." [PMID:22304909, PMID:22304917] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0061840 name: high-affinity ferrous iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:bhm, PMID:9413439] synonym: "high affinity ferrous uptake transmembrane transporter activity" EXACT [] synonym: "high-affinity ferrous iron uptake transmembrane transporter activity" EXACT [] is_a: GO:0015093 ! ferrous iron transmembrane transporter activity [Term] id: GO:0061841 name: high-affinity iron exporter complex namespace: cellular_component def: "A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment." [GOC:bhm, PMID:10608875, PMID:9413439] comment: An example of this is FET5 in Saccharomyces cerevisiae (P43561) in PMID:9413439. synonym: "FET5-FTH1 high affinity iron exporter complex" NARROW [] synonym: "FET5-FTH1 high-affinity iron exporter complex" NARROW [] synonym: "high affinity iron exporter complex" EXACT [] xref: IntAct:EBI-12592993 is_a: GO:1902495 ! transmembrane transporter complex is_a: GO:1905862 ! ferroxidase complex relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0061842 name: microtubule organizing center localization namespace: biological_process def: "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell." [PMID:21281821] synonym: "microtubule organizing center polarity" NARROW [] synonym: "MTOC localization" EXACT [] synonym: "MTOC polarity" NARROW [] is_a: GO:0051179 ! localization [Term] id: GO:0061843 name: Sertoli cell barrier remodeling namespace: biological_process def: "The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle." [PMID:20534520, PMID:24467744] synonym: "blood testis barrier restructuring" BROAD [] synonym: "restructuring of blood-testis barrier" BROAD [] synonym: "restructuring of BTB" BROAD [] synonym: "restructuring of SCB" EXACT [] synonym: "SCB remodeling" EXACT [] synonym: "Sertoli cell barrier restructuring" EXACT [] is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0061844 name: antimicrobial humoral immune response mediated by antimicrobial peptide namespace: biological_process def: "An immune response against microbes mediated by anti-microbial peptides in body fluid." [PMID:15761415, PMID:24287494] synonym: "antimicrobial peptide-mediated antimicrobial humoral response" EXACT [] synonym: "peptide-mediated antimicrobial humoral response" BROAD [] is_a: GO:0019730 ! antimicrobial humoral response [Term] id: GO:0061845 name: neuron projection branch point namespace: cellular_component def: "The location where a secondary projection arises from a neuron projection." [PMID:25586189] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0061846 name: dendritic spine cytoplasm namespace: cellular_component def: "The region of the neuronal cytoplasm located in dendritic spines." [PMID:15673667] is_a: GO:0032839 ! dendrite cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0043197 ! dendritic spine relationship: part_of GO:0043197 ! dendritic spine [Term] id: GO:0061847 name: response to cholecystokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0061848 name: cellular response to cholecystokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] is_a: GO:0061847 ! response to cholecystokinin is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0061849 name: telomeric G-quadruplex DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:16142245, PMID:9512530] is_a: GO:0042162 ! telomeric DNA binding is_a: GO:0051880 ! G-quadruplex DNA binding [Term] id: GO:0061850 name: growth cone leading edge namespace: cellular_component def: "That part of the growth cone which represents the distal part of the structure." [PMID:10797548] is_a: GO:0031252 ! cell leading edge intersection_of: GO:0031252 ! cell leading edge intersection_of: part_of GO:0090725 ! peripheral region of growth cone relationship: part_of GO:0090725 ! peripheral region of growth cone [Term] id: GO:0061851 name: leading edge of lamellipodium namespace: cellular_component def: "That part of the lamellipodium which represents the distal part of the structure." [PMID:22339865] is_a: GO:0031252 ! cell leading edge intersection_of: GO:0031252 ! cell leading edge intersection_of: part_of GO:0030027 ! lamellipodium relationship: part_of GO:0030027 ! lamellipodium [Term] id: GO:0061852 name: retrograte transporter complex, Golgi to ER namespace: cellular_component def: "Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles." [GOC:bhm, PMID:16093310] comment: An example of this is ERV41 in Saccharomyces cerevisiae (Q04651) in PMID:16093310 (inferred from direct assay). synonym: "ERV41-ERV46 retrograde receptor complex" NARROW [] synonym: "retrograte receptor complex, Golgi to endoplasmic reticulum" EXACT [] synonym: "retrograte receptor complex, Golgi to ER" EXACT [] synonym: "retrograte transporter complex, Golgi to endoplasmic reticulum" EXACT [] is_a: GO:1990351 ! transporter complex created_by: dph creation_date: 2017-02-28T13:56:56Z [Term] id: GO:0061853 name: regulation of neuroblast migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097402 ! neuroblast migration relationship: regulates GO:0097402 ! neuroblast migration created_by: dph creation_date: 2017-03-08T18:17:07Z [Term] id: GO:0061854 name: positive regulation of neuroblast migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097402 ! neuroblast migration relationship: positively_regulates GO:0097402 ! neuroblast migration created_by: dph creation_date: 2017-03-08T18:22:30Z [Term] id: GO:0061855 name: negative regulation of neuroblast migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097402 ! neuroblast migration relationship: negatively_regulates GO:0097402 ! neuroblast migration created_by: dph creation_date: 2017-03-08T18:26:21Z [Term] id: GO:0061856 name: Golgi calcium ion transmembrane transport namespace: biological_process def: "A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore." [PMID:21811607] is_a: GO:0032472 ! Golgi calcium ion transport is_a: GO:0070588 ! calcium ion transmembrane transport created_by: dph creation_date: 2017-03-14T16:08:23Z [Term] id: GO:0061857 name: endoplasmic reticulum stress-induced pre-emptive quality control namespace: biological_process def: "The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome." [PMID:17129784, PMID:26565908] synonym: "ER pQC" EXACT [] synonym: "ER stress-indiced pre-emptive quality control" EXACT [] is_a: GO:0034976 ! response to endoplasmic reticulum stress created_by: dph creation_date: 2017-03-28T13:05:03Z [Term] id: GO:0061860 name: DNA clamp unloader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex." [GOC:vw, PMID:23499004] is_a: GO:0003677 ! DNA binding is_a: GO:0042623 ! ATPase activity, coupled relationship: part_of GO:0090618 ! DNA clamp unloading created_by: dph creation_date: 2017-04-03T11:49:46Z [Term] id: GO:0061862 name: cellular response to differentiation-inducing factor 2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [PMID:19684855] synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT [] synonym: "cellular response to DIF-2" RELATED [] synonym: "cellular response to DIF2" RELATED [] is_a: GO:0051716 ! cellular response to stimulus is_a: GO:1905960 ! response to differentiation-inducing factor 2 created_by: dph creation_date: 2017-04-07T17:14:16Z [Term] id: GO:0061863 name: microtubule plus end polymerase namespace: molecular_function def: "Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers." [PMID:27872152] is_a: GO:0016740 ! transferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0000226 ! microtubule cytoskeleton organization created_by: dph creation_date: 2017-04-07T17:36:57Z [Term] id: GO:0061864 name: basement membrane constituent secretion namespace: biological_process def: "The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell." [PMID:26610918, PMID:28228250] is_a: GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2017-04-07T18:23:39Z [Term] id: GO:0061865 name: polarized secretion of basement membrane proteins in epithelium namespace: biological_process def: "The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium." [PMID:26610918, PMID:28228250] is_a: GO:0061864 ! basement membrane constituent secretion created_by: dph creation_date: 2017-04-07T18:26:02Z [Term] id: GO:0061866 name: negative regulation of histone H3-S10 phosphorylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to histone H3 on a serine residue at position 10." [PMID:27521428] is_a: GO:0033128 ! negative regulation of histone phosphorylation is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043987 ! histone H3-S10 phosphorylation relationship: negatively_regulates GO:0043987 ! histone H3-S10 phosphorylation created_by: dph creation_date: 2017-04-07T18:45:51Z [Term] id: GO:0061867 name: establishment of mitotic spindle asymmetry namespace: biological_process def: "The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure." [PMID:26659188] is_a: GO:0007052 ! mitotic spindle organization created_by: dph creation_date: 2017-04-28T12:39:13Z [Term] id: GO:0061868 name: hepatic stellate cell migration namespace: biological_process def: "The orderly movement of a hepatic stellate cell from one site to another." [PMID:24204762] is_a: GO:0010761 ! fibroblast migration created_by: dph creation_date: 2017-05-01T13:01:40Z [Term] id: GO:0061869 name: regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010762 ! regulation of fibroblast migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061868 ! hepatic stellate cell migration relationship: regulates GO:0061868 ! hepatic stellate cell migration created_by: dph creation_date: 2017-05-01T13:04:20Z [Term] id: GO:0061870 name: positive regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that increases the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010763 ! positive regulation of fibroblast migration is_a: GO:0061869 ! regulation of hepatic stellate cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061868 ! hepatic stellate cell migration relationship: positively_regulates GO:0061868 ! hepatic stellate cell migration created_by: dph creation_date: 2017-05-01T13:17:23Z [Term] id: GO:0061871 name: negative regulation of hepatic stellate cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] is_a: GO:0010764 ! negative regulation of fibroblast migration is_a: GO:0061869 ! regulation of hepatic stellate cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061868 ! hepatic stellate cell migration relationship: negatively_regulates GO:0061868 ! hepatic stellate cell migration created_by: dph creation_date: 2017-05-01T13:20:51Z [Term] id: GO:0061872 name: hepatic stellate cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell." [PMID:24204762] is_a: GO:0070252 ! actin-mediated cell contraction created_by: dph creation_date: 2017-05-01T13:25:18Z [Term] id: GO:0061873 name: regulation of hepatic stellate cell contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061872 ! hepatic stellate cell contraction relationship: regulates GO:0061872 ! hepatic stellate cell contraction created_by: dph creation_date: 2017-05-01T13:26:49Z [Term] id: GO:0061874 name: positive regulation of hepatic stellate cell contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] is_a: GO:0061873 ! regulation of hepatic stellate cell contraction is_a: GO:1903116 ! positive regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061872 ! hepatic stellate cell contraction relationship: positively_regulates GO:0061872 ! hepatic stellate cell contraction created_by: dph creation_date: 2017-05-01T13:29:30Z [Term] id: GO:0061875 name: negative regulation of hepatic stellate cell contraction namespace: biological_process def: "Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0061873 ! regulation of hepatic stellate cell contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061872 ! hepatic stellate cell contraction relationship: negatively_regulates GO:0061872 ! hepatic stellate cell contraction created_by: dph creation_date: 2017-05-01T13:31:42Z [Term] id: GO:0061880 name: regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098957 ! anterograde axonal transport of mitochondrion relationship: regulates GO:0098957 ! anterograde axonal transport of mitochondrion created_by: dph creation_date: 2017-05-30T14:15:46Z [Term] id: GO:0061881 name: positive regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion relationship: positively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion created_by: dph creation_date: 2017-05-30T14:21:08Z [Term] id: GO:0061882 name: negative regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion relationship: negatively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion created_by: dph creation_date: 2017-05-30T14:25:16Z [Term] id: GO:0061883 name: clathrin-dependent endocytosis involved in vitellogenesis namespace: biological_process def: "A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition." [PMID:26265702] synonym: "clathrin-dependent endocytosis involved in yolk formation" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0072583 ! clathrin-dependent endocytosis intersection_of: GO:0072583 ! clathrin-dependent endocytosis intersection_of: part_of GO:0007296 ! vitellogenesis relationship: part_of GO:0007296 ! vitellogenesis created_by: dph creation_date: 2017-05-30T14:41:21Z [Term] id: GO:0061884 name: regulation of mini excitatory postsynaptic potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098816 ! mini excitatory postsynaptic potential relationship: regulates GO:0098816 ! mini excitatory postsynaptic potential created_by: dph creation_date: 2017-05-30T15:35:46Z [Term] id: GO:0061885 name: positive regulation of mini excitatory postsynaptic potential namespace: biological_process def: "Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential is_a: GO:2000463 ! positive regulation of excitatory postsynaptic potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098816 ! mini excitatory postsynaptic potential relationship: positively_regulates GO:0098816 ! mini excitatory postsynaptic potential created_by: dph creation_date: 2017-05-30T15:46:16Z [Term] id: GO:0061886 name: negative regulation of mini excitatory postsynaptic potential namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential is_a: GO:0090394 ! negative regulation of excitatory postsynaptic potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098816 ! mini excitatory postsynaptic potential relationship: negatively_regulates GO:0098816 ! mini excitatory postsynaptic potential created_by: dph creation_date: 2017-05-30T15:50:08Z [Term] id: GO:0061887 name: reproduction of symbiont in host namespace: biological_process def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms, occurring within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23460907, PMID:25713147] is_a: GO:0000003 ! reproduction is_a: GO:0044403 ! symbiotic process created_by: dph creation_date: 2017-06-01T18:07:47Z [Term] id: GO:0061888 name: regulation of astrocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048710 ! regulation of astrocyte differentiation is_a: GO:0050865 ! regulation of cell activation is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048143 ! astrocyte activation relationship: regulates GO:0048143 ! astrocyte activation created_by: dph creation_date: 2017-06-01T22:26:29Z [Term] id: GO:0061889 name: negative regulation of astrocyte activation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048712 ! negative regulation of astrocyte differentiation is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048143 ! astrocyte activation relationship: negatively_regulates GO:0048143 ! astrocyte activation created_by: dph creation_date: 2017-06-01T22:29:43Z [Term] id: GO:0061890 name: positive regulation of astrocyte activation namespace: biological_process def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048711 ! positive regulation of astrocyte differentiation is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048143 ! astrocyte activation relationship: positively_regulates GO:0048143 ! astrocyte activation created_by: dph creation_date: 2017-06-01T22:31:50Z [Term] id: GO:0061891 name: calcium ion sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)." [PMID:16005298, PMID:17020874, PMID:28151650] is_a: GO:0005509 ! calcium ion binding is_a: GO:0140299 ! small molecule sensor activity created_by: dph creation_date: 2017-06-01T23:37:01Z [Term] id: GO:0061896 name: all-trans retinol 3,4-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] xref: RHEA:50292 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2017-06-12T14:49:30Z [Term] id: GO:0061897 name: all-trans retinal 3,4-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2017-06-12T14:56:58Z [Term] id: GO:0061898 name: all-trans retinoic acid 3,4-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinoic acid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2017-06-12T15:01:23Z [Term] id: GO:0061899 name: 11-cis-retinal 3,4-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2017-06-12T15:03:57Z [Term] id: GO:0061900 name: glial cell activation namespace: biological_process def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082] is_a: GO:0001775 ! cell activation relationship: part_of GO:0150076 ! neuroinflammatory response created_by: dph creation_date: 2017-06-13T13:06:23Z [Term] id: GO:0061901 name: regulation of 1-phosphatidylinositol-3-kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity relationship: regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity created_by: dph creation_date: 2017-06-22T19:34:56Z [Term] id: GO:0061902 name: negative regulation of 1-phosphatidylinositol-3-kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process is_a: GO:0043553 ! negative regulation of phosphatidylinositol 3-kinase activity is_a: GO:0061901 ! regulation of 1-phosphatidylinositol-3-kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity relationship: negatively_regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity created_by: dph creation_date: 2017-06-22T19:51:34Z [Term] id: GO:0061903 name: positive regulation of 1-phosphatidylinositol-3-kinase activity namespace: biological_process def: "Any process that starts or increases the frequency or rate of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] is_a: GO:0010513 ! positive regulation of phosphatidylinositol biosynthetic process is_a: GO:0043552 ! positive regulation of phosphatidylinositol 3-kinase activity is_a: GO:0061901 ! regulation of 1-phosphatidylinositol-3-kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity relationship: positively_regulates GO:0016303 ! 1-phosphatidylinositol-3-kinase activity created_by: dph creation_date: 2017-06-22T19:54:53Z [Term] id: GO:0061906 name: autophagosome localization namespace: biological_process def: "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell." [PMID:26763909] is_a: GO:0051640 ! organelle localization created_by: dph creation_date: 2017-06-28T17:27:57Z [Term] id: GO:0061907 name: negative regulation of AMPA receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity." [GOC:aruk, GOC:bc, PMID:20739563] is_a: GO:1900450 ! negative regulation of glutamate receptor signaling pathway is_a: GO:2000272 ! negative regulation of signaling receptor activity is_a: GO:2000311 ! regulation of AMPA receptor activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004971 ! AMPA glutamate receptor activity relationship: negatively_regulates GO:0004971 ! AMPA glutamate receptor activity created_by: dph creation_date: 2017-06-29T11:55:11Z [Term] id: GO:0061908 name: phagophore namespace: cellular_component def: "A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle." [PMID:22664348, PMID:24201109] synonym: "isolation membrane" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: dph creation_date: 2017-06-29T16:59:19Z [Term] id: GO:0061909 name: autophagosome-lysosome fusion namespace: biological_process def: "The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [PMID:28077293] synonym: "autophagosome fusion" BROAD [] synonym: "autophagosome-vacuole fusion" EXACT [] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0016236 ! macroautophagy created_by: dph creation_date: 2017-06-29T17:07:52Z [Term] id: GO:0061910 name: autophagosome-endosome fusion namespace: biological_process def: "The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome." [PMID:24219988] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0016236 ! macroautophagy created_by: dph creation_date: 2017-06-29T17:10:43Z [Term] id: GO:0061911 name: amphisome-lysosome fusion namespace: biological_process def: "The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome." [PMID:24219988] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0016236 ! macroautophagy created_by: dph creation_date: 2017-07-05T18:54:52Z [Term] id: GO:0061912 name: selective autophagy namespace: biological_process def: "The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490] is_a: GO:0016236 ! macroautophagy created_by: dph creation_date: 2017-07-07T17:27:37Z [Term] id: GO:0061913 name: positive regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0061036 ! positive regulation of cartilage development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1903012 ! positive regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation relationship: positively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2017-07-10T17:31:09Z [Term] id: GO:0061914 name: negative regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0061037 ! negative regulation of cartilage development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1903011 ! negative regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation relationship: negatively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2017-07-10T17:39:17Z [Term] id: GO:0061915 name: actin fusion focus localization namespace: biological_process def: "Any process in which an actin fusion focus are transported to, or maintained in, a specific location. The actin fusion focus is an aster-like, F-actin-containing structure at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion." [PMID:28410370] synonym: "actin fusion focus localisation" EXACT [] is_a: GO:0051641 ! cellular localization created_by: dph creation_date: 2017-07-10T18:11:47Z [Term] id: GO:0061916 name: leading edge of axonal growth cone namespace: cellular_component def: "That part of the axonal growth cone which represents the distal part of the structure." [PMID:16098134] synonym: "axonal growth cone leading edge" EXACT [] synonym: "distal tip of axonal growth cone" EXACT [] is_a: GO:0061850 ! growth cone leading edge intersection_of: GO:0031252 ! cell leading edge intersection_of: part_of GO:0044295 ! axonal growth cone intersection_of: part_of GO:0090725 ! peripheral region of growth cone relationship: part_of GO:0044295 ! axonal growth cone created_by: dph creation_date: 2017-07-10T19:17:21Z [Term] id: GO:0061917 name: leading edge of dendritic growth cone namespace: cellular_component def: "That part of the dendritic growth cone which represents the distal part of the structure." [PMID:16098134] synonym: "dendritic growth cone leading edge" EXACT [] synonym: "distal tip of dendritic growth cone" EXACT [] is_a: GO:0061850 ! growth cone leading edge intersection_of: GO:0031252 ! cell leading edge intersection_of: part_of GO:0044294 ! dendritic growth cone intersection_of: part_of GO:0090725 ! peripheral region of growth cone relationship: part_of GO:0044294 ! dendritic growth cone created_by: dph creation_date: 2017-07-10T19:25:23Z [Term] id: GO:0061919 name: process utilizing autophagic mechanism namespace: biological_process def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process created_by: dph creation_date: 2017-07-13T19:42:14Z [Term] id: GO:0061920 name: protein propionyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide." [PMID:17267393] is_a: GO:0016410 ! N-acyltransferase activity created_by: dph creation_date: 2017-08-02T13:35:22Z [Term] id: GO:0061921 name: peptidyl-lysine propionylation namespace: biological_process def: "The propionylation of peptidyl-lysine." [PMID:17267393] is_a: GO:0043543 ! protein acylation created_by: dph creation_date: 2017-08-02T13:37:14Z [Term] id: GO:0061922 name: histone propionyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone." [PMID:17267393] is_a: GO:0061920 ! protein propionyltransferase activity created_by: dph creation_date: 2017-08-02T13:38:50Z [Term] id: GO:0061923 name: (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene." [PMID:27862766] synonym: "protoillud-7-ene synthase activity" RELATED [] is_a: GO:0010334 ! sesquiterpene synthase activity created_by: dph creation_date: 2017-08-02T15:48:21Z [Term] id: GO:0061924 name: regulation of formation of radial glial scaffolds namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441] synonym: "regulation of Bergmann fiber biosynthesis" RELATED [] synonym: "regulation of Bergmann fiber formation" RELATED [] synonym: "regulation of radial glial scaffold formation" EXACT [] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0021943 ! formation of radial glial scaffolds relationship: regulates GO:0021943 ! formation of radial glial scaffolds created_by: dph creation_date: 2017-08-02T16:17:31Z [Term] id: GO:0061925 name: negative regulation of formation of radial glial scaffolds namespace: biological_process def: "Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441] synonym: "negative regulation of Bergmann fiber biosynthesis" RELATED [] synonym: "negative regulation of Bergmann fiber formation" RELATED [] synonym: "negative regulation of radial glial scaffold formation" EXACT [] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0061924 ! regulation of formation of radial glial scaffolds intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021943 ! formation of radial glial scaffolds relationship: negatively_regulates GO:0021943 ! formation of radial glial scaffolds created_by: dph creation_date: 2017-08-02T16:24:27Z [Term] id: GO:0061926 name: positive regulation of formation of radial glial scaffolds namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds." [PMID:22076441] synonym: "positive regulation of Bergmann fiber biosynthesis" RELATED [] synonym: "positive regulation of Bergmann fiber formation" RELATED [] synonym: "positive regulation of radial glial scaffold formation" EXACT [] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0061924 ! regulation of formation of radial glial scaffolds intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0021943 ! formation of radial glial scaffolds relationship: positively_regulates GO:0021943 ! formation of radial glial scaffolds created_by: dph creation_date: 2017-08-02T16:29:37Z [Term] id: GO:0061927 name: TOC-TIC supercomplex I namespace: cellular_component def: "The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110." [PMID:28745032] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0009507 ! chloroplast created_by: dph creation_date: 2017-08-28T13:18:20Z [Term] id: GO:0061928 name: glutathione specific gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623] xref: EC:4.3.2.7 is_a: GO:0016842 ! amidine-lyase activity created_by: dph creation_date: 2017-08-29T14:55:30Z [Term] id: GO:0061929 name: gamma-glutamylaminecyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907] xref: EC:4.3.2.8 is_a: GO:0016842 ! amidine-lyase activity created_by: dph creation_date: 2017-08-29T14:57:39Z [Term] id: GO:0061930 name: regulation of erythrocyte enucleation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] is_a: GO:0045646 ! regulation of erythrocyte differentiation is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043131 ! erythrocyte enucleation relationship: regulates GO:0043131 ! erythrocyte enucleation created_by: dph creation_date: 2017-09-05T12:48:05Z [Term] id: GO:0061931 name: positive regulation of erythrocyte enucleation namespace: biological_process def: "Any process that increases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] is_a: GO:0045648 ! positive regulation of erythrocyte differentiation is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0061930 ! regulation of erythrocyte enucleation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043131 ! erythrocyte enucleation relationship: positively_regulates GO:0043131 ! erythrocyte enucleation created_by: dph creation_date: 2017-09-05T12:57:33Z [Term] id: GO:0061932 name: negative regulation of erythrocyte enucleation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] is_a: GO:0045647 ! negative regulation of erythrocyte differentiation is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0061930 ! regulation of erythrocyte enucleation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043131 ! erythrocyte enucleation relationship: negatively_regulates GO:0043131 ! erythrocyte enucleation created_by: dph creation_date: 2017-09-05T13:00:15Z [Term] id: GO:0061934 name: regulation of adenine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adenine biosynthetic process." [PMID:19933844] is_a: GO:0006141 ! regulation of purine nucleobase metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046084 ! adenine biosynthetic process relationship: regulates GO:0046084 ! adenine biosynthetic process created_by: dph creation_date: 2017-09-05T14:58:46Z [Term] id: GO:0061935 name: fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes namespace: biological_process def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes." [GOC:dph] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0009677 ! double fertilization forming two zygotes created_by: dph creation_date: 2017-09-05T18:38:08Z [Term] id: GO:0061936 name: fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm namespace: biological_process def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm." [PMID:21123745] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0009567 ! double fertilization forming a zygote and endosperm created_by: dph creation_date: 2017-09-05T18:43:24Z [Term] id: GO:0061938 name: protein localization to somatodendritic compartment namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993] synonym: "somatodendritic protein localization" EXACT [] is_a: GO:0008104 ! protein localization created_by: dph creation_date: 2017-09-08T13:22:26Z [Term] id: GO:0061939 name: c-di-GMP signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal." [PMID:22864416, PMID:28057864] synonym: "3',5'-cyclic di-GMP signaling" EXACT [] synonym: "cyclic di-(3':5')-guanosine monophosphate signaling" EXACT [] synonym: "cyclic di-GMP signaling" EXACT [] synonym: "cyclic diguanylate signaling" EXACT [] is_a: GO:0007267 ! cell-cell signaling created_by: dph creation_date: 2017-09-14T18:59:04Z [Term] id: GO:0061940 name: regulation of c-di-GMP signaling namespace: biological_process def: "Any process that modulates the rate frequency or extent of c-di-GMP signaling." [PMID:22864416] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061939 ! c-di-GMP signaling relationship: regulates GO:0061939 ! c-di-GMP signaling created_by: dph creation_date: 2017-09-14T19:07:41Z [Term] id: GO:0061941 name: positive regulation of c-di-GMP signaling namespace: biological_process def: "Any process that increases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0061940 ! regulation of c-di-GMP signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061939 ! c-di-GMP signaling relationship: positively_regulates GO:0061939 ! c-di-GMP signaling created_by: dph creation_date: 2017-09-14T19:11:15Z [Term] id: GO:0061942 name: negative regulation of c-di-GMP signaling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0061940 ! regulation of c-di-GMP signaling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061939 ! c-di-GMP signaling relationship: negatively_regulates GO:0061939 ! c-di-GMP signaling created_by: dph creation_date: 2017-09-14T19:13:44Z [Term] id: GO:0061944 name: negative regulation of protein K48-linked ubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:BHF, GOC:rph, PMID:23460740] is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination is_a: GO:1902915 ! negative regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070936 ! protein K48-linked ubiquitination relationship: negatively_regulates GO:0070936 ! protein K48-linked ubiquitination created_by: dph creation_date: 2017-09-22T11:37:18Z [Term] id: GO:0061945 name: regulation of protein K48-linked ubiquitination namespace: biological_process def: "Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [PMID:23460740] is_a: GO:1902914 ! regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070936 ! protein K48-linked ubiquitination relationship: regulates GO:0070936 ! protein K48-linked ubiquitination created_by: dph creation_date: 2017-09-22T11:45:43Z [Term] id: GO:0061948 name: premature acrosome loss namespace: biological_process def: "The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:19153666, PMID:21380641, PMID:26655718] comment: If the release of the acrosome content when the sperm reaches to the zona pellucida, consider using acrosome reaction. synonym: "spontaneous acrosome loss" EXACT [] is_a: GO:0022414 ! reproductive process created_by: dph creation_date: 2017-10-25T17:46:55Z [Term] id: GO:0061949 name: regulation of premature acrosome loss namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248] is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061948 ! premature acrosome loss relationship: regulates GO:0061948 ! premature acrosome loss created_by: dph creation_date: 2017-10-25T17:51:32Z [Term] id: GO:0061950 name: negative regulation of premature acrosome loss namespace: biological_process def: "Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248] synonym: "negative regulation of spontaneous acrosome loss" EXACT [] is_a: GO:0061949 ! regulation of premature acrosome loss is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061948 ! premature acrosome loss relationship: negatively_regulates GO:0061948 ! premature acrosome loss created_by: dph creation_date: 2017-10-25T17:56:47Z [Term] id: GO:0061951 name: establishment of protein localization to plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] is_a: GO:0072659 ! protein localization to plasma membrane is_a: GO:0090150 ! establishment of protein localization to membrane created_by: dph creation_date: 2017-10-26T12:55:15Z [Term] id: GO:0061952 name: midbody abscission namespace: biological_process def: "The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934] synonym: "cell separation during cytokinesis" EXACT [] synonym: "cytokinetic abscission" EXACT [] is_a: GO:0061024 ! membrane organization is_a: GO:1902410 ! mitotic cytokinetic process created_by: dph creation_date: 2017-11-07T19:44:37Z [Term] id: GO:0061953 name: mRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA." [PMID:29072297] is_a: GO:0008174 ! mRNA methyltransferase activity created_by: dph creation_date: 2017-11-08T13:26:35Z [Term] id: GO:0061954 name: positive regulation of actin filament polymerization involved in sperm capacitation namespace: biological_process def: "Any process that icreases the rate or extent of actin polymerization as part of sperm capacitation. This process prevents a spontaneous acrosome reaction." [PMID:15749953, PMID:25966627, PMID:26514336, PMID:27178669] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030838 ! positive regulation of actin filament polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0048240 ! sperm capacitation intersection_of: positively_regulates GO:0030041 ! actin filament polymerization relationship: part_of GO:0048240 ! sperm capacitation created_by: dph creation_date: 2017-11-10T19:40:00Z [Term] id: GO:0061955 name: positive regulation of actin filament depolymerization involved in acrosome reaction namespace: biological_process def: "Any process that increases the rate or exent of actin depolymerization as part of the acrosome reaction. This allows the acrosomal membrane and plasma membrane to fuse." [PMID:20937821] is_a: GO:0022414 ! reproductive process is_a: GO:0030836 ! positive regulation of actin filament depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0007340 ! acrosome reaction intersection_of: positively_regulates GO:0030042 ! actin filament depolymerization relationship: part_of GO:0007340 ! acrosome reaction created_by: dph creation_date: 2017-11-10T19:43:18Z [Term] id: GO:0061956 name: penetration of cumulus oophorus namespace: biological_process def: "The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [PMID:21380641] synonym: "penetration of cumulus cells layer" EXACT [] synonym: "penetration of cumulus mass" EXACT [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007338 ! single fertilization created_by: dph creation_date: 2017-11-10T20:14:18Z [Term] id: GO:0061957 name: NVT complex namespace: cellular_component def: "A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1." [PMID:26365378] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2017-12-01T17:01:17Z [Term] id: GO:0061959 name: response to (R)-carnitine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus." [PMID:28102299] synonym: "response to L-carnitine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug is_a: GO:0060359 ! response to ammonium ion created_by: dph creation_date: 2018-01-19T13:31:39Z [Term] id: GO:0061960 name: regulation of heme oxygenase activity namespace: biological_process def: "Any process that modulates the frequency, or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004392 ! heme oxygenase (decyclizing) activity relationship: regulates GO:0004392 ! heme oxygenase (decyclizing) activity created_by: dph creation_date: 2018-01-22T20:24:06Z [Term] id: GO:0061961 name: positive regulation of heme oxygenase activity namespace: biological_process def: "Any process that activates or increases the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:0061960 ! regulation of heme oxygenase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004392 ! heme oxygenase (decyclizing) activity relationship: positively_regulates GO:0004392 ! heme oxygenase (decyclizing) activity created_by: dph creation_date: 2018-01-22T20:32:05Z [Term] id: GO:0061962 name: negative regulation of heme oxygenase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:0061960 ! regulation of heme oxygenase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004392 ! heme oxygenase (decyclizing) activity relationship: negatively_regulates GO:0004392 ! heme oxygenase (decyclizing) activity created_by: dph creation_date: 2018-01-22T20:37:03Z [Term] id: GO:0061963 name: regulation of entry into reproductive diapause namespace: biological_process def: "Any process that modulates the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0055116 ! entry into reproductive diapause relationship: regulates GO:0055116 ! entry into reproductive diapause created_by: dph creation_date: 2018-02-05T15:02:16Z [Term] id: GO:0061964 name: negative regulation of entry into reproductive diapause namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0061963 ! regulation of entry into reproductive diapause intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0055116 ! entry into reproductive diapause relationship: negatively_regulates GO:0055116 ! entry into reproductive diapause created_by: dph creation_date: 2018-02-05T15:04:33Z [Term] id: GO:0061965 name: positive regulation of entry into reproductive diapause namespace: biological_process def: "Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061963 ! regulation of entry into reproductive diapause intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0055116 ! entry into reproductive diapause relationship: positively_regulates GO:0055116 ! entry into reproductive diapause created_by: dph creation_date: 2018-02-05T15:06:51Z [Term] id: GO:0061966 name: establishment of left/right asymmetry namespace: biological_process def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] is_a: GO:0007368 ! determination of left/right symmetry created_by: dph creation_date: 2018-02-12T16:27:20Z [Term] id: GO:0061967 name: establishment of left sidedness namespace: biological_process def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side." [GOC:18629866, GOC:BHF] is_a: GO:0061966 ! establishment of left/right asymmetry created_by: dph creation_date: 2018-02-12T16:32:41Z [Term] id: GO:0061968 name: maintenance of left/right asymmetry namespace: biological_process def: "The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] is_a: GO:0007389 ! pattern specification process created_by: dph creation_date: 2018-02-12T16:38:47Z [Term] id: GO:0061969 name: maintenance of left sidedness namespace: biological_process def: "The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] is_a: GO:0061968 ! maintenance of left/right asymmetry created_by: dph creation_date: 2018-02-12T16:41:30Z [Term] id: GO:0061970 name: maintenance of right sidedness namespace: biological_process def: "The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] is_a: GO:0061968 ! maintenance of left/right asymmetry created_by: dph creation_date: 2018-02-12T16:45:33Z [Term] id: GO:0061971 name: replacement bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [DOI:10.1002/(SICI)1097-4687(199608)229\:2<121\:\:AID-JMOR1>3.0.CO;2-4] is_a: GO:0060349 ! bone morphogenesis created_by: dph creation_date: 2018-02-12T18:10:59Z [Term] id: GO:0061972 name: dermal bone morphogenesis namespace: biological_process def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632] is_a: GO:0061973 ! membrane bone morphogenesis created_by: dph creation_date: 2018-02-12T18:16:21Z [Term] id: GO:0061973 name: membrane bone morphogenesis namespace: biological_process def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374] is_a: GO:0060349 ! bone morphogenesis created_by: dph creation_date: 2018-02-12T18:21:09Z [Term] id: GO:0061974 name: perichondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone." [PMID:21901110] is_a: GO:0060350 ! endochondral bone morphogenesis is_a: GO:0061973 ! membrane bone morphogenesis created_by: dph creation_date: 2018-02-12T18:26:10Z [Term] id: GO:0061975 name: articular cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure." [PMID:20097540, PMID:20679519] synonym: "articular cartilage of joint development" EXACT [] is_a: GO:0051216 ! cartilage development created_by: dph creation_date: 2018-02-12T19:57:31Z [Term] id: GO:0061976 name: temporomandibular joint articular cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure." [PMID:20679519] is_a: GO:0061975 ! articular cartilage development created_by: dph creation_date: 2018-02-12T20:01:00Z [Term] id: GO:0061977 name: hip joint articular cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure." [PMID:20097540] is_a: GO:0061975 ! articular cartilage development created_by: dph creation_date: 2018-02-12T20:03:22Z [Term] id: GO:0061978 name: mandibular condyle articular cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure." [PMID:20679519] is_a: GO:0061976 ! temporomandibular joint articular cartilage development created_by: dph creation_date: 2018-02-12T20:04:49Z [Term] id: GO:0061979 name: femoral head articular cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure." [PMID:20097540] is_a: GO:0061977 ! hip joint articular cartilage development created_by: dph creation_date: 2018-02-12T20:06:21Z [Term] id: GO:0061980 name: regulatory RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961] is_a: GO:0003723 ! RNA binding created_by: dph creation_date: 2018-02-13T21:46:08Z [Term] id: GO:0061981 name: 3-hydroxykynureninase activity namespace: molecular_function def: "Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine." [PMID:17300176] xref: RHEA:25143 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances created_by: dph creation_date: 2018-02-14T16:12:49Z [Term] id: GO:0061982 name: meiosis I cell cycle process namespace: biological_process def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] synonym: "first meiotic cell division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:27:20Z [Term] id: GO:0061983 name: meiosis II cell cycle process namespace: biological_process def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] synonym: "second meiotic division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:37:44Z [Term] id: GO:0061984 name: catabolite repression namespace: biological_process def: "A process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources." [GOC:dph, PMID:29197127, PMID:29295552] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031670 ! cellular response to nutrient created_by: dph creation_date: 2018-02-15T16:34:14Z [Term] id: GO:0061985 name: carbon catabolite repression namespace: biological_process def: "A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources." [PMID:29295552] is_a: GO:0061984 ! catabolite repression created_by: dph creation_date: 2018-02-15T16:49:48Z [Term] id: GO:0061986 name: negative regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that decreases the frequency, rate or extent or transcription." [PMID:11875061] is_a: GO:0046015 ! regulation of transcription by glucose created_by: dph creation_date: 2018-02-15T17:39:14Z [Term] id: GO:0061987 name: negative regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter." [PMID:11875061] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0061986 ! negative regulation of transcription by glucose created_by: dph creation_date: 2018-02-15T17:48:00Z [Term] id: GO:0061988 name: karyosome formation namespace: biological_process def: "The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0007276 ! gamete generation created_by: dph creation_date: 2018-02-15T21:24:08Z [Term] id: GO:0061989 name: sperm karyosome formation namespace: biological_process def: "The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886] is_a: GO:0061988 ! karyosome formation relationship: part_of GO:0007283 ! spermatogenesis created_by: dph creation_date: 2018-02-15T21:29:47Z [Term] id: GO:0061990 name: beta-ketodecanoyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2" [EC:2.3.1.207, PMID:22753057] xref: MetaCyc:RXN-13613 is_a: GO:0016415 ! octanoyltransferase activity created_by: dph creation_date: 2018-02-15T22:29:03Z [Term] id: GO:0061992 name: ATP-dependent chaperone mediated protein folding namespace: biological_process def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and dependent on ATP hydrolysis." [PMID:18311152] is_a: GO:0061077 ! chaperone-mediated protein folding created_by: dph creation_date: 2018-02-15T23:34:28Z [Term] id: GO:0061993 name: calcium:proton antiporter complex namespace: cellular_component def: "A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [GOC:bhm, PMID:19098009, PMID:28645169] synonym: "CAX1 homodimer" NARROW [GOC:bhm] synonym: "CAX1-CAX3 complex" NARROW [GOC:bhm] synonym: "CAX3 homodimer" NARROW [GOC:bhm] xref: IntAct:EBI-16693477 xref: IntAct:EBI-16710427 xref: IntAct:EBI-2292448 is_a: GO:1902495 ! transmembrane transporter complex created_by: dph creation_date: 2018-02-16T02:17:10Z [Term] id: GO:0061994 name: ATP-dependent protein-nucleic acid complex displacement activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate coupled to the displacement of proteins or protein complexes from nucleic acid, sometimes in a 'wire stripping' fashion." [PMID:18593879] is_a: GO:0008094 ! DNA-dependent ATPase activity created_by: dph creation_date: 2018-02-16T15:42:22Z [Term] id: GO:0061995 name: ATP-dependent protein-DNA complex displacement activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate coupled to the displacement of proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion." [PMID:18593879] is_a: GO:0061994 ! ATP-dependent protein-nucleic acid complex displacement activity created_by: dph creation_date: 2018-02-16T15:46:47Z [Term] id: GO:0061999 name: regulation of cardiac endothelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140074 ! cardiac endothelial to mesenchymal transition relationship: regulates GO:0140074 ! cardiac endothelial to mesenchymal transition created_by: dph creation_date: 2018-02-16T16:26:51Z [Term] id: GO:0062000 name: positive regulation of cardiac endothelial to mesenchymal transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition relationship: positively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition created_by: dph creation_date: 2018-02-16T16:31:06Z [Term] id: GO:0062001 name: negative regulation of cardiac endothelial to mesenchymal transition namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition relationship: negatively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition created_by: dph creation_date: 2018-02-16T16:36:48Z [Term] id: GO:0062002 name: regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity namespace: biological_process def: "Any process that modulates the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0051336 ! regulation of hydrolase activity is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity relationship: regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity created_by: dph creation_date: 2018-02-26T13:16:39Z [Term] id: GO:0062003 name: negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity namespace: biological_process def: "Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0062002 ! regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity relationship: negatively_regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity created_by: dph creation_date: 2018-02-26T13:23:20Z [Term] id: GO:0062009 name: secondary palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences." [PMID:28784960] is_a: GO:0060021 ! roof of mouth development created_by: dph creation_date: 2018-02-26T22:55:20Z [Term] id: GO:0062010 name: primitive palate development namespace: biological_process def: "The biological process whose specific outcome is the progression of the primitive palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure." [GOC:dph] is_a: GO:0060021 ! roof of mouth development created_by: dph creation_date: 2018-02-26T23:00:48Z [Term] id: GO:0062011 name: mitochondrial respiratory chain complex IV pre-assembly complex namespace: cellular_component def: "A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components." [GOC:lnp, PMID:21068384] synonym: "COX pre-assemply complex" BROAD [GOC:lnp] synonym: "COX1 preassemply complex" EXACT [GOC:lnp] is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:0101031 ! chaperone complex created_by: dph creation_date: 2018-02-28T14:50:26Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044281 ! small molecule metabolic process relationship: regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044281 ! small molecule metabolic process relationship: positively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044281 ! small molecule metabolic process relationship: negatively_regulates GO:0044281 ! small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0062021 name: mitotic cohesin dsDNA (leading strand) loading namespace: biological_process def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle." [GOC:vw, PMID:29358048] is_a: GO:0061780 ! mitotic cohesin loading created_by: dph creation_date: 2018-04-06T13:04:41Z [Term] id: GO:0062022 name: mitotic cohesin ssDNA (lagging strand) loading namespace: biological_process def: "The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle." [GOC:vw, PMID:29358048] synonym: "second-DNA capture" EXACT [GOC:vw] is_a: GO:0061780 ! mitotic cohesin loading created_by: dph creation_date: 2018-04-06T13:06:36Z [Term] id: GO:0062023 name: collagen-containing extracellular matrix namespace: cellular_component def: "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617] is_a: GO:0031012 ! extracellular matrix created_by: dph creation_date: 2018-04-13T12:47:21Z [Term] id: GO:0062025 name: regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process created_by: dph creation_date: 2018-04-16T13:54:43Z [Term] id: GO:0062026 name: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process namespace: biological_process def: "Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process created_by: dph creation_date: 2018-04-16T14:02:20Z [Term] id: GO:0062027 name: positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process namespace: biological_process def: "Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process created_by: dph creation_date: 2018-04-16T14:05:19Z [Term] id: GO:0062028 name: regulation of stress granule assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034063 ! stress granule assembly relationship: regulates GO:0034063 ! stress granule assembly created_by: dph creation_date: 2018-04-16T19:12:41Z [Term] id: GO:0062029 name: positive regulation of stress granule assembly namespace: biological_process def: "Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] is_a: GO:0062028 ! regulation of stress granule assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034063 ! stress granule assembly relationship: positively_regulates GO:0034063 ! stress granule assembly created_by: dph creation_date: 2018-04-16T19:17:10Z [Term] id: GO:0062030 name: negative regulation of stress granule assembly namespace: biological_process def: "Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] is_a: GO:0062028 ! regulation of stress granule assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034063 ! stress granule assembly relationship: negatively_regulates GO:0034063 ! stress granule assembly created_by: dph creation_date: 2018-04-16T19:19:32Z [Term] id: GO:0062031 name: filamentous growth MAPK cascade namespace: biological_process def: "The MAPK cascade which is activated as a result of partial nutrient deprivation and which results in filamentous growth." [PMID:17604854] is_a: GO:0051403 ! stress-activated MAPK cascade created_by: dph creation_date: 2018-04-17T15:18:44Z [Term] id: GO:0062032 name: cichorine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi." [PMID:24244835] synonym: "cichorine anabolism" EXACT [] synonym: "cichorine biosynthesis" EXACT [] synonym: "cichorine formation" EXACT [] synonym: "cichorine synthesis" EXACT [] is_a: GO:0044550 ! secondary metabolite biosynthetic process created_by: dph creation_date: 2018-04-19T16:22:09Z [Term] id: GO:0062033 name: positive regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000070 ! mitotic sister chromatid segregation relationship: positively_regulates GO:0000070 ! mitotic sister chromatid segregation created_by: dph creation_date: 2018-04-23T14:32:23Z [Term] id: GO:0062034 name: L-pipecolic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine." [PMID:27758894, PMID:28330936] synonym: "L-pipecolate biosynthetic process" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: dph creation_date: 2018-04-24T12:19:36Z [Term] id: GO:0062035 name: sensory perception of cold stimulus namespace: biological_process def: "The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241] is_a: GO:0050955 ! thermoception created_by: dph creation_date: 2018-04-30T13:48:10Z [Term] id: GO:0062036 name: sensory perception of hot stimulus namespace: biological_process def: "The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241] is_a: GO:0050955 ! thermoception created_by: dph creation_date: 2018-04-30T13:50:47Z [Term] id: GO:0062037 name: D-loop DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind." [PMID:20924116] synonym: "DNA displacement loop binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding created_by: dph creation_date: 2018-04-30T15:21:21Z [Term] id: GO:0062038 name: positive regulation of pheromone response MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade." [PMID:9315645] is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0090028 ! positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0071507 ! pheromone response MAPK cascade relationship: positively_regulates GO:0071507 ! pheromone response MAPK cascade created_by: dph creation_date: 2018-05-01T13:00:56Z [Term] id: GO:0062039 name: biofilm matrix namespace: cellular_component def: "A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells." [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088] is_a: GO:0031012 ! extracellular matrix created_by: dph creation_date: 2018-05-04T12:49:17Z [Term] id: GO:0062040 name: fungal biofilm matrix namespace: cellular_component def: "An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses." [GOC:BHF, PMID:27129222, PMID:28516088] is_a: GO:0062039 ! biofilm matrix created_by: dph creation_date: 2018-05-04T12:54:39Z [Term] id: GO:0062041 name: positive regulation of meiotic sister chromatid arm separation namespace: biological_process def: "Any process that increases the rate or exent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [PMID:20383139] is_a: GO:0060903 ! positive regulation of meiosis I is_a: GO:1905134 ! positive regulation of meiotic chromosome separation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051755 ! meiotic sister chromatid arm separation relationship: positively_regulates GO:0051755 ! meiotic sister chromatid arm separation created_by: dph creation_date: 2018-05-04T18:20:28Z [Term] id: GO:0062042 name: regulation of cardiac epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: regulates GO:0060317 ! cardiac epithelial to mesenchymal transition created_by: dph creation_date: 2018-05-10T18:09:31Z [Term] id: GO:0062043 name: positive regulation of cardiac epithelial to mesenchymal transition namespace: biological_process def: "Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: positively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition created_by: dph creation_date: 2018-05-10T18:15:54Z [Term] id: GO:0062044 name: negative regulation of cardiac epithelial to mesenchymal transition namespace: biological_process def: "Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BFH, GOC:rph, PMID:20951801] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition is_a: GO:0110111 ! negative regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: negatively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition created_by: dph creation_date: 2018-05-10T18:21:00Z [Term] id: GO:0062045 name: L-lysine alpha-aminotransferase namespace: molecular_function def: "Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine." [PMID:27758894, PMID:28330936] is_a: GO:0008483 ! transaminase activity created_by: dph creation_date: 2018-05-11T12:13:57Z [Term] id: GO:0062046 name: dehydropipecolic acid reductase namespace: molecular_function def: "Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+." [PMID:27758894, PMID:28330936] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor created_by: dph creation_date: 2018-05-11T12:16:00Z [Term] id: GO:0062047 name: pipecolic acid N-hydroxylase namespace: molecular_function def: "Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O." [PMID:27758894, PMID:28330936] is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen created_by: dph creation_date: 2018-05-11T12:17:15Z [Term] id: GO:0062048 name: lymphotoxin complex namespace: cellular_component def: "A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations." [PMID:1733951] synonym: "lymphotoxin alpha-beta" NARROW [] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2018-05-18T18:34:55Z [Term] id: GO:0062049 name: protein phosphatase inhibitor complex namespace: cellular_component def: "A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase." [GOC:bhm, PMID:19407142, PMID:19933100] xref: ComplexPortal:CPX-1620 is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2018-05-30T19:03:26Z [Term] id: GO:0062050 name: GPI-mannose ethanolamine phosphate phosphodiesterase activity namespace: molecular_function def: "A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor." [PMID:19837036] is_a: GO:0008081 ! phosphoric diester hydrolase activity created_by: dph creation_date: 2018-06-01T18:26:54Z [Term] id: GO:0062051 name: lipopolysaccharide transport system namespace: cellular_component def: "A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner." [PMID:29449493] is_a: GO:1990351 ! transporter complex created_by: dph creation_date: 2018-06-04T18:44:40Z [Term] id: GO:0062052 name: starch granule initiation namespace: biological_process def: "The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts." [PMID:28684429] is_a: GO:0019252 ! starch biosynthetic process created_by: dph creation_date: 2018-06-08T17:18:57Z [Term] id: GO:0062054 name: fluoride channel activity namespace: molecular_function def: "Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [PMID:23991286, PMID:25156118] is_a: GO:0005253 ! anion channel activity is_a: GO:1903425 ! fluoride transmembrane transporter activity created_by: dph creation_date: 2018-06-25T13:30:23Z [Term] id: GO:0062055 name: photosynthetic state transition namespace: biological_process def: "A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems." [PMID:29967049] is_a: GO:0042548 ! regulation of photosynthesis, light reaction created_by: dph creation_date: 2018-07-16T14:00:57Z [Term] id: GO:0062056 name: compound eye pigment cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia." [GOC:ha, PMID:8929534] is_a: GO:0050931 ! pigment cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis created_by: dph creation_date: 2018-08-01T12:59:42Z [Term] id: GO:0062057 name: L-aspartate:fumarate antiporter activity namespace: molecular_function def: "Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)." [PMID:29995997] is_a: GO:0015138 ! fumarate transmembrane transporter activity is_a: GO:0015183 ! L-aspartate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity created_by: dph creation_date: 2018-08-09T14:25:45Z [Term] id: GO:0062058 name: transcription factor TFIIH holo complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor TFIIH holo complex." [PMID:11259578] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:44:17Z [Term] id: GO:0062059 name: FACT complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FACT complex." [PMID:10682845] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:49:30Z [Term] id: GO:0062060 name: NuA4 histone acetyltransferase complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a NuA4 histone acetyltransferase complex." [PMID:15528408] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:51:45Z [Term] id: GO:0062061 name: TAP complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a TAP complex." [PMID:17947644] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:54:22Z [Term] id: GO:0062062 name: oligosaccharyltransferase complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an oligosaccharyltransferase complex." [PMID:12887896] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:56:32Z [Term] id: GO:0062063 name: BBSome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a BBSome complex." [PMID:20603001] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T13:59:18Z [Term] id: GO:0062064 name: box C/D snoRNP complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a box C/D snoRNP complex." [PMID:10679015] is_a: GO:0030519 ! snoRNP binding created_by: dph creation_date: 2018-08-31T14:01:03Z [Term] id: GO:0062065 name: box H/ACA snoRNP complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a box H/ACA snoRNP complex." [PMID:10679015] is_a: GO:0030519 ! snoRNP binding created_by: dph creation_date: 2018-08-31T14:03:43Z [Term] id: GO:0062066 name: PSII associated light-harvesting complex II binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PSII associated light-harvesting complex II." [PMID:17400553] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T14:06:01Z [Term] id: GO:0062067 name: chloroplast photosystem I binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chloroplast photosystem I." [PMID:17400553] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T14:07:46Z [Term] id: GO:0062068 name: chloroplast photosystem II binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chloroplast photosystem II." [PMID:17400553] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T14:09:17Z [Term] id: GO:0062069 name: GARP complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GARP complex." [PMID:20163565] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T14:11:17Z [Term] id: GO:0062070 name: SAGA complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SAGA complex." [PMID:27185460] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-08-31T14:13:36Z [Term] id: GO:0062071 name: Pi Mi complex namespace: cellular_component def: "A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis." [PMID:30089908] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: dph creation_date: 2018-09-04T13:40:52Z [Term] id: GO:0062072 name: H3K9me3 modified histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 9 has been modified by trimethylation." [PMID:30110338] is_a: GO:0035064 ! methylated histone binding created_by: dph creation_date: 2018-09-05T12:58:43Z [Term] id: GO:0062073 name: histone mRNA stem-loop binding complex namespace: cellular_component def: "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export." [GOC:bhm, PMID:18025107, PMID:23286197] synonym: "SLBP-MIF4GD complex" NARROW [] synonym: "SLBP-SLIP1 complex" NARROW [] xref: ComplexPortal:CPX-1305 xref: ComplexPortal:CPX-1311 xref: ComplexPortal:CPX-1312 xref: ComplexPortal:CPX-1313 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: dph creation_date: 2018-09-10T13:46:56Z [Term] id: GO:0062074 name: pollen aperture namespace: cellular_component def: "An area where exine is reduced or absent, in the pollen wall." [PMID:30150313] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043667 ! pollen wall created_by: dph creation_date: 2018-09-19T19:19:58Z [Term] id: GO:0062075 name: pollen aperture formation namespace: biological_process def: "The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall." [PMID:30150313] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0010208 ! pollen wall assembly created_by: dph creation_date: 2018-09-19T19:25:59Z [Term] id: GO:0062076 name: acyl-CoA delta5-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O." [PMID:10601301, PMID:10769175] synonym: "Acyl-CoA (8-3)-desaturase" EXACT [] synonym: "acyl-CoA D5-desaturase activity" EXACT [] synonym: "acyl-CoA delta(5)-desaturase activity" EXACT [] xref: EC:1.14.19.44 is_a: GO:0016215 ! acyl-CoA desaturase activity created_by: dph creation_date: 2018-09-24T15:33:59Z [Term] id: GO:0062077 name: phenylacetyl-CoA 1,2-epoxidase complex namespace: cellular_component def: "A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)." [GOC:bhm, PMID:21247899] synonym: "paaABCE complex" NARROW [] xref: ComplexPortal:CPX-2844 is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005623 ! cell created_by: dph creation_date: 2018-09-27T12:40:04Z [Term] id: GO:0062078 name: TSC1-TSC2 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a TSC1-TSC2 complex." [PMID:28561066] synonym: "tuberin sclerosis complex binding" EXACT [] synonym: "tuberin-hamartin complex binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: dph creation_date: 2018-10-11T12:31:42Z [Term] id: GO:0062079 name: ATG2-ATG18 complex namespace: cellular_component def: "A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae." [GOC:bhm, PMID:23230146] xref: ComplexPortal:CPX-361 is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0034045 ! phagophore assembly site membrane created_by: dph creation_date: 2018-10-12T13:47:25Z [Term] id: GO:0062080 name: inhibitory MHC class Ib receptor activity namespace: molecular_function def: "Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] is_a: GO:0032394 ! MHC class Ib receptor activity created_by: dph creation_date: 2018-10-15T15:03:44Z [Term] id: GO:0062081 name: activating MHC class Ib receptor activity namespace: molecular_function def: "Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte." [DOI:10.1002/9780470015902.a0024246] is_a: GO:0032394 ! MHC class Ib receptor activity created_by: dph creation_date: 2018-10-15T15:05:07Z [Term] id: GO:0062082 name: HLA-E specific inhibitory MHC class Ib receptor activity namespace: molecular_function def: "Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity created_by: dph creation_date: 2018-10-15T15:06:22Z [Term] id: GO:0062083 name: HLA-G specific inhibitory MHC class Ib receptor activity namespace: molecular_function def: "Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity created_by: dph creation_date: 2018-10-15T15:06:44Z [Term] id: GO:0062084 name: regulation of capsule polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:1901913 ! regulation of capsule organization is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045227 ! capsule polysaccharide biosynthetic process relationship: regulates GO:0045227 ! capsule polysaccharide biosynthetic process created_by: dph creation_date: 2018-10-31T15:58:08Z [Term] id: GO:0062085 name: positive regulation of capsule polysaccharide biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062084 ! regulation of capsule polysaccharide biosynthetic process is_a: GO:1901915 ! positive regulation of capsule organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045227 ! capsule polysaccharide biosynthetic process relationship: positively_regulates GO:0045227 ! capsule polysaccharide biosynthetic process created_by: dph creation_date: 2018-10-31T16:02:00Z [Term] id: GO:0062086 name: regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] is_a: GO:0003056 ! regulation of vascular smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014826 ! vein smooth muscle contraction relationship: regulates GO:0014826 ! vein smooth muscle contraction created_by: dph creation_date: 2018-11-02T15:17:26Z [Term] id: GO:0062087 name: positive regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] is_a: GO:0062086 ! regulation of vein smooth muscle contraction is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014826 ! vein smooth muscle contraction relationship: positively_regulates GO:0014826 ! vein smooth muscle contraction created_by: dph creation_date: 2018-11-02T15:20:47Z [Term] id: GO:0062088 name: negative regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] is_a: GO:0062086 ! regulation of vein smooth muscle contraction is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014826 ! vein smooth muscle contraction relationship: negatively_regulates GO:0014826 ! vein smooth muscle contraction created_by: dph creation_date: 2018-11-02T15:28:32Z [Term] id: GO:0062089 name: regulation of taurine biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042412 ! taurine biosynthetic process relationship: regulates GO:0042412 ! taurine biosynthetic process created_by: dph creation_date: 2018-11-07T14:05:44Z [Term] id: GO:0062090 name: positive regulation of taurine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0062089 ! regulation of taurine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042412 ! taurine biosynthetic process relationship: positively_regulates GO:0042412 ! taurine biosynthetic process created_by: dph creation_date: 2018-11-07T14:10:58Z [Term] id: GO:0062091 name: Ycf2/FtsHi complex namespace: cellular_component def: "A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma." [PMID:30309901] synonym: "TIC complex associated chloroplast protein import motor" EXACT [] is_a: GO:1904949 ! ATPase complex created_by: dph creation_date: 2018-11-08T20:06:11Z [Term] id: GO:0062092 name: Yae1-Lto1 complex namespace: cellular_component def: "A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p." [PMID:26182403] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: dph creation_date: 2018-11-15T17:39:46Z [Term] id: GO:0062093 name: lysophagy namespace: biological_process def: "The selective autophagy process in which a damaged lysosome is degraded by macroautophagy." [PMID:28743755] is_a: GO:0061912 ! selective autophagy created_by: dph creation_date: 2018-11-20T16:47:11Z [Term] id: GO:0062094 name: stomach development namespace: biological_process def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0048565 ! digestive tract development created_by: dph creation_date: 2018-11-20T18:15:45Z [Term] id: GO:0062095 name: endoplasmic reticulum-peroxisome tethering namespace: biological_process def: "The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:28463579] is_a: GO:0060151 ! peroxisome localization is_a: GO:0140056 ! organelle localization by membrane tethering created_by: dph creation_date: 2018-11-21T13:28:50Z [Term] id: GO:0062096 name: kinetochore disassembly namespace: biological_process def: "The disaggregation of a kinetochore into its constituent components." [GOC:mah, PMID:27611693] is_a: GO:0051383 ! kinetochore organization is_a: GO:1903008 ! organelle disassembly created_by: dph creation_date: 2018-11-26T16:34:55Z [Term] id: GO:0062097 name: chemosynthesis namespace: biological_process def: "The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane." [PMID:25050523] xref: Wikipedia:Chemosynthesis is_a: GO:0044237 ! cellular metabolic process created_by: dph creation_date: 2018-11-29T13:18:55Z [Term] id: GO:0062098 name: regulation of programmed necrotic cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097300 ! programmed necrotic cell death relationship: regulates GO:0097300 ! programmed necrotic cell death created_by: dph creation_date: 2018-11-29T14:58:26Z [Term] id: GO:0062099 name: negative regulation of programmed necrotic cell death namespace: biological_process def: "Any process that decreases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0060547 ! negative regulation of necrotic cell death is_a: GO:0062098 ! regulation of programmed necrotic cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097300 ! programmed necrotic cell death relationship: negatively_regulates GO:0097300 ! programmed necrotic cell death created_by: dph creation_date: 2018-11-29T15:05:56Z [Term] id: GO:0062100 name: positive regulation of programmed necrotic cell death namespace: biological_process def: "Any process that increases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] is_a: GO:0010940 ! positive regulation of necrotic cell death is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0062098 ! regulation of programmed necrotic cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097300 ! programmed necrotic cell death relationship: positively_regulates GO:0097300 ! programmed necrotic cell death created_by: dph creation_date: 2018-11-29T15:08:35Z [Term] id: GO:0062101 name: peptidyl-aspartic acid 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2." [PMID:1378441, PMID:1856229] xref: EC:1.14.11.16 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN xref: RHEA:11508 is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: dph creation_date: 2018-12-06T14:01:15Z [Term] id: GO:0062102 name: female germline stem cell symmetric division namespace: biological_process def: "Division of a female germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:ha, PMID:30248087] is_a: GO:0098729 ! germline stem cell symmetric division created_by: dph creation_date: 2018-12-18T14:17:54Z [Term] id: GO:0062103 name: double-stranded RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of double-stranded RNA." [PMID:19701182] synonym: "double-stranded RNA biosynthesis" EXACT [] synonym: "dsRNA biosynthesis" EXACT [] synonym: "dsRNA biosynthetic process" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] is_a: GO:0032774 ! RNA biosynthetic process created_by: dph creation_date: 2019-01-07T13:29:47Z [Term] id: GO:0062104 name: pumilio-response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA." [PMID:30601114] synonym: "PRE binding" EXACT [PMID:30601114] is_a: GO:0003723 ! RNA binding created_by: dph creation_date: 2019-01-11T13:38:26Z [Term] id: GO:0062105 name: RNA 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide." [PMID:30626973, RHEA:58956] xref: RHEA:58956 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008173 ! RNA methyltransferase activity created_by: dph creation_date: 2019-01-23T14:23:00Z [Term] id: GO:0062107 name: regulation of protein localization to non-growing cell tip namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707] is_a: GO:1903066 ! regulation of protein localization to cell tip intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902487 ! protein localization to non-growing cell tip relationship: regulates GO:1902487 ! protein localization to non-growing cell tip created_by: dph creation_date: 2019-02-05T12:59:18Z [Term] id: GO:0062108 name: negative regulation of protein localization to non-growing cell tip namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707] is_a: GO:0062107 ! regulation of protein localization to non-growing cell tip is_a: GO:1903067 ! negative regulation of protein localization to cell tip intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902487 ! protein localization to non-growing cell tip relationship: negatively_regulates GO:1902487 ! protein localization to non-growing cell tip created_by: dph creation_date: 2019-02-05T13:03:52Z [Term] id: GO:0062109 name: regulation of DNA recombinase disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of DNA recombinase disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990986 ! DNA recombinase disassembly relationship: regulates GO:1990986 ! DNA recombinase disassembly created_by: dph creation_date: 2019-02-05T13:53:19Z [Term] id: GO:0062110 name: negative regulation of DNA recombinase disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419] is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:0062109 ! regulation of DNA recombinase disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990986 ! DNA recombinase disassembly relationship: negatively_regulates GO:1990986 ! DNA recombinase disassembly created_by: dph creation_date: 2019-02-05T13:57:35Z [Term] id: GO:0062111 name: zinc ion import into organelle namespace: biological_process def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle." [PMID:29529046] is_a: GO:0071577 ! zinc ion transmembrane transport created_by: dph creation_date: 2019-02-05T15:27:38Z [Term] id: GO:0062112 name: fatty acid primary amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a fatty acid primary amide." [PMID:10079066, PMID:15952893] synonym: "FAPA biosynthesis" EXACT [] synonym: "FAPA biosynthetic process" EXACT [] synonym: "fatty acid amide biosynthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0062126 ! fatty acid primary amide metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process created_by: dph creation_date: 2019-02-20T12:49:43Z [Term] id: GO:0062113 name: early phagosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an eary phagosome." [PMID:18813294] synonym: "early phagocytic vesicle lumen" EXACT [] is_a: GO:0097013 ! phagocytic vesicle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0032009 ! early phagosome relationship: part_of GO:0032009 ! early phagosome created_by: dph creation_date: 2019-02-22T12:58:47Z [Term] id: GO:0062116 name: phenyloplast namespace: cellular_component def: "A chloroplast-derived plastid in which the solid form of phenol is stored." [PMID:24683183] is_a: GO:0009536 ! plastid created_by: dph creation_date: 2019-03-15T11:57:05Z [Term] id: GO:0062119 name: LinE complex namespace: cellular_component def: "A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: dph creation_date: 2019-03-19T14:00:26Z [Term] id: GO:0062120 name: LinE complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030999 ! linear element assembly created_by: dph creation_date: 2019-03-19T14:14:25Z [Term] id: GO:0062121 name: linear element maturation namespace: biological_process def: "The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements." [PMID:30640914] synonym: "LinE chromosome loading" EXACT [GOC:mah] synonym: "LinE focus formation" EXACT [GOC:mah] is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0030999 ! linear element assembly created_by: dph creation_date: 2019-03-19T14:19:27Z [Term] id: GO:0062122 name: histone methyltransferase activity (H3-K37 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group onto lysine at position 37 of the histone H3 protein." [PMID:30773398] synonym: "histone lysine N-methyltransferase activity (H3-K37 specific)" EXACT [] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity created_by: dph creation_date: 2019-04-01T13:30:11Z [Term] id: GO:0062123 name: regulation of linear element maturation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of linear element maturation." [PMID:30640914] is_a: GO:0090006 ! regulation of linear element assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0062121 ! linear element maturation relationship: regulates GO:0062121 ! linear element maturation created_by: dph creation_date: 2019-04-23T13:36:20Z [Term] id: GO:0062124 name: 4-hydroxybutyrate receptor activity namespace: molecular_function def: "Combining with 4-hydroxybutyrte to initiate a change in cell activity." [PMID:17197387] synonym: "gamma-hydroxybutyrate receptor activity" EXACT [PMID:17197387] is_a: GO:0038023 ! signaling receptor activity created_by: dph creation_date: 2019-05-15T12:22:38Z [Term] id: GO:0062125 name: regulation of mitochondrial gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA)." [PMID:28285835] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140053 ! mitochondrial gene expression relationship: regulates GO:0140053 ! mitochondrial gene expression created_by: dph creation_date: 2019-05-30T16:45:04Z [Term] id: GO:0062126 name: fatty acid primary amide metabolic process namespace: biological_process def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides." [PMID:11128635] synonym: "primary fatty amide metabolic process" EXACT [] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process created_by: dph creation_date: 2019-05-30T18:23:02Z [Term] id: GO:0062127 name: fatty acid primary amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary fatty amides." [PMID:11128635] synonym: "primary fatty amide catabolic process" EXACT [] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0062126 ! fatty acid primary amide metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901569 ! fatty acid derivative catabolic process created_by: dph creation_date: 2019-05-30T18:26:49Z [Term] id: GO:0062128 name: MutSgamma complex namespace: cellular_component def: "A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5." [PMID:27648641, PMID:7622037, PMID:8001134, PMID:9374523] synonym: "Msh4-Msh5 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: dph creation_date: 2019-06-04T14:48:15Z [Term] id: GO:0062129 name: chitin-based extracellular matrix namespace: cellular_component def: "Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet." [PMID:23955854] synonym: "chitin-based ECM" EXACT [GOC:dph] is_a: GO:0031012 ! extracellular matrix created_by: dph creation_date: 2019-06-13T12:57:13Z [Term] id: GO:0062130 name: adhesive extracellular matrix namespace: cellular_component def: "A extracellular matrix which attaches an organism to a substrate." [GOC:dph, GOC:ha, PMID:825230] synonym: "puparial glue" NARROW [GOC:ha] is_a: GO:0031012 ! extracellular matrix created_by: dph creation_date: 2019-06-21T12:35:06Z [Term] id: GO:0062131 name: 3-butenylglucosinolate 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O." [PMID:18945935] synonym: "But-3-enyl Glucosinolate-2-hydroxylase activity" EXACT [] xref: MetaCyc:RXNQT-4343 xref: RHEA:60628 is_a: GO:0051213 ! dioxygenase activity created_by: dph creation_date: 2019-06-24T16:45:18Z [Term] id: GO:0062132 name: regulation of L-glutamine biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901704 ! L-glutamine biosynthetic process relationship: regulates GO:1901704 ! L-glutamine biosynthetic process created_by: dph creation_date: 2019-06-27T13:44:21Z [Term] id: GO:0062133 name: negative regulation of L-glutamine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901704 ! L-glutamine biosynthetic process relationship: negatively_regulates GO:1901704 ! L-glutamine biosynthetic process created_by: dph creation_date: 2019-06-27T13:47:21Z [Term] id: GO:0062134 name: positive regulation of L-glutamine biosynthetic process namespace: biological_process def: "Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901704 ! L-glutamine biosynthetic process relationship: positively_regulates GO:1901704 ! L-glutamine biosynthetic process created_by: dph creation_date: 2019-06-27T13:49:29Z [Term] id: GO:0062136 name: low-density lipoprotein receptor complex namespace: cellular_component def: "A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors." [GOC:bhm, PMID:26005850] synonym: "LDL receptor complex" EXACT [GOC:dph] synonym: "LDLR complex" EXACT [GOC:dph] synonym: "low-density lipoprotein particle receptor complex" EXACT [GOC:dph] is_a: GO:0062137 ! cargo receptor complex is_a: GO:0098797 ! plasma membrane protein complex created_by: dph creation_date: 2019-07-02T13:41:28Z [Term] id: GO:0062137 name: cargo receptor complex namespace: cellular_component def: "Any protein complex that is part of a membrane and which functions as a cargo receptor." [PMID:27903609] is_a: GO:0098796 ! membrane protein complex created_by: dph creation_date: 2019-07-08T18:09:01Z [Term] id: GO:0062139 name: camera-type eye photoreceptor cell development namespace: biological_process def: "The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure." [PMID:20648062, PMID:30237290] is_a: GO:0042462 ! eye photoreceptor cell development relationship: part_of GO:0043010 ! camera-type eye development created_by: dph creation_date: 2019-08-06T12:40:36Z [Term] id: GO:0062140 name: septin collar of invasive hyphae namespace: cellular_component def: "A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell." [PMID:29567712] is_a: GO:0032173 ! septin collar created_by: dph creation_date: 2019-08-06T14:31:04Z [Term] id: GO:0062141 name: nuclear exosome targeting complex namespace: cellular_component def: "A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts." [PMID:21855801, PMID:29844170] synonym: "NEXT complex" EXACT [PMID:21855801, PMID:29844170] is_a: GO:0032991 ! protein-containing complex created_by: dph creation_date: 2019-08-29T14:46:59Z [Term] id: GO:0062142 name: L-beta-ethynylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria." [PMID:3082841, PMID:30867596] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043453 ! alkyne biosynthetic process created_by: dph creation_date: 2019-09-02T16:39:59Z [Term] id: GO:0062143 name: L-propargylglycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria." [PMID:30867596] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043453 ! alkyne biosynthetic process created_by: dph creation_date: 2019-09-02T16:45:12Z [Term] id: GO:0062144 name: L-propargylglycine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine." [PMID:30867596, RHEA:59892] xref: RHEA:58892 is_a: GO:0016848 ! carbon-halide lyase activity created_by: dph creation_date: 2019-09-02T16:48:52Z [Term] id: GO:0062145 name: L-propargylglycine--L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate." [PMID:30867596, RHEA:59896] xref: RHEA:59896 is_a: GO:0016881 ! acid-amino acid ligase activity created_by: dph creation_date: 2019-09-02T16:56:59Z [Term] id: GO:0062146 name: 4-chloro-allylglycine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)." [PMID:30867596, RHEA:59888] xref: RHEA:59888 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2019-09-02T16:59:30Z [Term] id: GO:0062147 name: L-lysine 4-chlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate." [PMID:30867596, RHEA:59884] xref: RHEA:59884 is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated created_by: dph creation_date: 2019-09-02T17:01:46Z [Term] id: GO:0062148 name: L-gamma-glutamyl-L-propargylglycine hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate." [PMID:30867596, RHEA:59900] xref: RHEA:59900 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity created_by: dph creation_date: 2019-09-02T17:04:43Z [Term] id: GO:0062149 name: detection of stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0019233 ! sensory perception of pain relationship: part_of GO:0019233 ! sensory perception of pain created_by: dph creation_date: 2019-09-13T13:48:47Z [Term] id: GO:0062150 name: amorpha-4,11-diene 12-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]" [EC:1.14.14.114, PMID:16458889, PMID:16612385, PMID:23246612, RHEA:32999] xref: EC:1.14.14.114 xref: RHEA:32999 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: dph creation_date: 2019-09-13T14:48:12Z [Term] id: GO:0062151 name: catalase complex namespace: cellular_component def: "A protein-containing complex that is capable of catalase activity." [GOC:bhm, PMID:10656833] is_a: GO:1990204 ! oxidoreductase complex created_by: dph creation_date: 2019-09-17T12:18:02Z [Term] id: GO:0062152 name: mRNA (cytidine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine." [PMID:22395603, PMID:23871666, RHEA:61464] synonym: "mRNA (cytosine-5-)-methyltransferase activity" EXACT [] xref: RHEA:61464 is_a: GO:0008174 ! mRNA methyltransferase activity created_by: dph creation_date: 2019-09-18T14:40:32Z [Term] id: GO:0062153 name: C5-methylcytidine-containing RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule modified by C5-methylcytidine." [PMID:28418038] synonym: "C5-methylcytosine-containing RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding created_by: dph creation_date: 2019-09-18T14:46:22Z [Term] id: GO:0062154 name: N6-mAMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + H2O + N6-methyl-AMP = IMP + methylamine." [PMID:29884623, RHEA:16001] synonym: "MAPDA" EXACT [PMID:29884623] xref: RHEA:16001 is_a: GO:0019239 ! deaminase activity created_by: dph creation_date: 2019-09-20T13:16:37Z [Term] id: GO:0062155 name: curli secretion complex namespace: cellular_component def: "A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms." [PMID:25219853] is_a: GO:1902495 ! transmembrane transporter complex relationship: part_of GO:0009279 ! cell outer membrane created_by: dph creation_date: 2019-09-20T14:05:13Z [Term] id: GO:0062156 name: mitochondrial ATP-gated potassium channel activity namespace: molecular_function def: "Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016] synonym: "mitochondrial potassium channel activity" EXACT [] synonym: "mitoK-ATP activity" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0035381 ! ATP-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity created_by: dph creation_date: 2019-09-20T16:07:07Z [Term] id: GO:0062157 name: mitochondrial ATP-gated potassium channel complex namespace: cellular_component def: "A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016] is_a: GO:0034705 ! potassium channel complex created_by: dph creation_date: 2019-09-20T16:17:05Z [Term] id: GO:0062158 name: chloride:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)." [PMID:14985752] is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity created_by: dph creation_date: 2019-09-24T19:26:32Z [Term] id: GO:0062159 name: contractile vacuole complex namespace: cellular_component def: "A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory." [PMID:23890380] synonym: "CVC" RELATED [PMID:23890380] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle created_by: dph creation_date: 2019-09-26T14:20:14Z [Term] id: GO:0062160 name: spongiome namespace: cellular_component def: "A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory." [PMID:23890380] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0062159 ! contractile vacuole complex created_by: dph creation_date: 2019-09-26T14:30:41Z [Term] id: GO:0062161 name: regulation of pyocyanine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477] synonym: "regulation of pyocyanin biosynthetic process" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0106220 ! pyocyanine biosynthetic process relationship: regulates GO:0106220 ! pyocyanine biosynthetic process created_by: dph creation_date: 2019-11-06T14:36:27Z [Term] id: GO:0062162 name: positive regulation of pyocyanine biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477] synonym: "positive regulation of pyocyanin biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0062161 ! regulation of pyocyanine biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0106220 ! pyocyanine biosynthetic process relationship: positively_regulates GO:0106220 ! pyocyanine biosynthetic process created_by: dph creation_date: 2019-11-06T14:40:35Z [Term] id: GO:0062163 name: pseudohyphal septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form a tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection." [PMID:29567712] is_a: GO:0000921 ! septin ring assembly created_by: dph creation_date: 2019-11-07T15:46:26Z [Term] id: GO:0062164 name: regulation of pseudohyphal septin ring assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0062163 ! pseudohyphal septin ring assembly relationship: regulates GO:0062163 ! pseudohyphal septin ring assembly created_by: dph creation_date: 2019-11-07T15:52:20Z [Term] id: GO:0062165 name: positive regulation of pseudohyphal septin ring assembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation." [PMID:29567712] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0062163 ! pseudohyphal septin ring assembly relationship: positively_regulates GO:0062163 ! pseudohyphal septin ring assembly created_by: dph creation_date: 2019-11-07T15:55:38Z [Term] id: GO:0062166 name: negative regulation of pseudohyphal septin ring assembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0062163 ! pseudohyphal septin ring assembly relationship: negatively_regulates GO:0062163 ! pseudohyphal septin ring assembly created_by: dph creation_date: 2019-11-07T15:57:39Z [Term] id: GO:0062167 name: complement component C1q complex namespace: cellular_component def: "A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning." [PMID:29449492] synonym: "C1q" EXACT [] synonym: "Complement 1q" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: dph creation_date: 2019-11-12T13:21:57Z [Term] id: GO:0062168 name: negative regulation of plus-end directed microtubule sliding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183] is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0062169 ! regulation of plus-end directed microtubule sliding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031535 ! plus-end directed microtubule sliding relationship: negatively_regulates GO:0031535 ! plus-end directed microtubule sliding created_by: dph creation_date: 2019-11-12T17:56:47Z [Term] id: GO:0062169 name: regulation of plus-end directed microtubule sliding namespace: biological_process def: "Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183] is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031535 ! plus-end directed microtubule sliding relationship: regulates GO:0031535 ! plus-end directed microtubule sliding created_by: dph creation_date: 2019-11-12T18:01:32Z [Term] id: GO:0062170 name: lutein metabolic process namespace: biological_process def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform lutein." [PMID:24397433] synonym: "lutein metabolism" EXACT [] is_a: GO:0016122 ! xanthophyll metabolic process created_by: dph creation_date: 2019-11-18T15:56:36Z [Term] id: GO:0062171 name: lutein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lutein." [PMID:24397433] synonym: "lutein anabolism" EXACT [] synonym: "lutein biosynthesis" EXACT [] synonym: "lutein formation" EXACT [] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:0062170 ! lutein metabolic process created_by: dph creation_date: 2019-11-18T16:01:00Z [Term] id: GO:0062172 name: lutein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lutein." [PMID:24397433] synonym: "lutein breakdown" EXACT [] synonym: "lutein catabolism" EXACT [] synonym: "lutein degradation" EXACT [] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:0062170 ! lutein metabolic process created_by: dph creation_date: 2019-11-18T16:06:07Z [Term] id: GO:0062173 name: brexanolone metabolic process namespace: biological_process def: "The chemical reactions and pathways by which living organisms transform brexanolone." [PMID:24390875] synonym: "allopregnanolone metabolic process" EXACT [] synonym: "allopregnanolone metabolism" EXACT [] synonym: "allotetrahydroprogesterone metabolic process" EXACT [] synonym: "allotetrahydroprogesterone metabolism" EXACT [] synonym: "brexanolone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: dph creation_date: 2019-11-18T19:42:45Z [Term] id: GO:0062174 name: brexanolone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of brexanolone." [PMID:24390875] synonym: "allopregnanolone anabolism" EXACT [] synonym: "allopregnanolone biosynthesis" EXACT [] synonym: "allopregnanolone biosynthetic process" EXACT [] synonym: "allopregnanolone synthesis" EXACT [] synonym: "allotetrahydroprogesterone anabolism" EXACT [] synonym: "allotetrahydroprogesterone biosynthesis" EXACT [] synonym: "allotetrahydroprogesterone biosynthetic process" EXACT [] synonym: "allotetrahydroprogesterone synthesis" EXACT [] synonym: "brexanolone anabolism" EXACT [] synonym: "brexanolone biosynthesis" EXACT [] synonym: "brexanolone synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0062173 ! brexanolone metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: dph creation_date: 2019-11-18T19:48:14Z [Term] id: GO:0062175 name: brexanolone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of brexanolone." [PMID:24390875] synonym: "allopregnanolone breakdown" EXACT [] synonym: "allopregnanolone catabolic process" EXACT [] synonym: "allopregnanolone catabolism" EXACT [] synonym: "allopregnanolone degradation" EXACT [] synonym: "allotetrahydroprogesterone breakdown" EXACT [] synonym: "allotetrahydroprogesterone catabolic process" EXACT [] synonym: "allotetrahydroprogesterone catabolism" EXACT [] synonym: "allotetrahydroprogesterone degradation" EXACT [] synonym: "brexanolone breakdown" EXACT [] synonym: "brexanolone catabolism" EXACT [] synonym: "brexanolone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0062173 ! brexanolone metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process created_by: dph creation_date: 2019-11-18T19:57:46Z [Term] id: GO:0062176 name: R-loop disassembly namespace: biological_process def: "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability." [PMID:28790157] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication created_by: dph creation_date: 2019-11-19T12:47:04Z [Term] id: GO:0062177 name: radial spoke assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules." [PMID:21613541, PMID:21692193, PMID:24124175, PMID:27940518, PMID:8408197] is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0035082 ! axoneme assembly created_by: dph creation_date: 2019-11-20T17:50:08Z [Term] id: GO:0062178 name: stationary phase namespace: biological_process def: "A single-celled organism vegetative growth phase when, due to nutrient limitation, growth rate and death rate are equal." [PMID:8393130] is_a: GO:0072690 ! single-celled organism vegetative growth phase created_by: dph creation_date: 2019-11-26T15:58:40Z [Term] id: GO:0062179 name: vitamin D 23-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-23 of any form of vitamin D." [PMID:22100522, PMID:30205156] is_a: GO:0004497 ! monooxygenase activity created_by: dph creation_date: 2019-11-26T17:10:29Z [Term] id: GO:0062180 name: 25-hydroxycholecalciferol-23-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:46616] xref: RHEA:46616 is_a: GO:0062179 ! vitamin D 23-hydroxylase activity created_by: dph creation_date: 2019-11-26T17:12:22Z [Term] id: GO:0062181 name: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity namespace: molecular_function def: "Catatlysis of the reaction: calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:49192] xref: RHEA:49192 is_a: GO:0062179 ! vitamin D 23-hydroxylase activity created_by: dph creation_date: 2019-11-26T17:16:39Z [Term] id: GO:0062182 name: all-trans retinoic acid 4-hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]" [PMID:9250660, PMID:9716180, RHEA:51492] xref: RHEA:51492 is_a: GO:0008401 ! retinoic acid 4-hydroxylase activity created_by: dph creation_date: 2019-11-26T18:36:06Z [Term] id: GO:0062183 name: all-trans retinoic acid 18-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:22020119, RHEA:55856] xref: RHEA:55856 is_a: GO:0004497 ! monooxygenase activity created_by: dph creation_date: 2019-11-26T18:41:32Z [Term] id: GO:0062184 name: testosterone 16-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:46304] xref: RHEA:46304 is_a: GO:0004497 ! monooxygenase activity created_by: dph creation_date: 2019-11-26T18:43:43Z [Term] id: GO:0062185 name: secalciferol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction:2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]." [PMID:10518789, RHEA:49064] xref: RHEA:49064 is_a: GO:0004497 ! monooxygenase activity created_by: dph creation_date: 2019-11-26T18:46:18Z [Term] id: GO:0062186 name: anandamide epoxidase activity namespace: molecular_function def: "Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide." [PMID:21289075] synonym: "arachidonoylethanolamide epoxidase activity" EXACT [PMID:21289075] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: dph creation_date: 2019-11-26T18:49:50Z [Term] id: GO:0062187 name: anandamide 8,9 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53140] xref: RHEA:53140 is_a: GO:0062186 ! anandamide epoxidase activity created_by: dph creation_date: 2019-11-26T18:51:34Z [Term] id: GO:0062188 name: anandamide 11,12 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53144] xref: RHEA:53144 is_a: GO:0062186 ! anandamide epoxidase activity created_by: dph creation_date: 2019-11-26T18:53:52Z [Term] id: GO:0062189 name: anandamide 14,15 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53148] xref: RHEA:53148 is_a: GO:0062186 ! anandamide epoxidase activity created_by: dph creation_date: 2019-11-26T18:57:55Z [Term] id: GO:0062191 name: galactoxylomannan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals." [PMID:16441437, PMID:18952901, PMID:19684080, PMID:21843086] synonym: "galactoxylomannan anabolism" EXACT [] synonym: "galactoxylomannan biosynthesis" EXACT [] synonym: "galactoxylomannan formation" EXACT [] synonym: "galactoxylomannan synthesis" EXACT [] synonym: "GalXM biosynthetic process" EXACT [] synonym: "glucuronoxylomannogalactan biosynthetic process" EXACT [] is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process created_by: dph creation_date: 2019-12-06T14:44:36Z [Term] id: GO:0062192 name: L-rhamnose mutarotase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose." [RHEA:25584] xref: EC:5.1.3.32 xref: RHEA:25584 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives created_by: dph creation_date: 2019-12-09T16:45:45Z [Term] id: GO:0062193 name: D-ribose pyranase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose." [RHEA:25432] xref: EC:5.4.99.62 xref: RHEA:25432 is_a: GO:0016866 ! intramolecular transferase activity created_by: dph creation_date: 2019-12-09T16:49:07Z [Term] id: GO:0062194 name: cytoplasmic microtubule minus-end namespace: cellular_component def: "A microtubule minus end that is part of a cytoplasmic microtubule." [PMID:18061564] is_a: GO:0036449 ! microtubule minus-end intersection_of: GO:0036449 ! microtubule minus-end intersection_of: part_of GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005881 ! cytoplasmic microtubule created_by: dph creation_date: 2019-12-09T19:06:36Z [Term] id: GO:0062195 name: microtubule bundle maintenance namespace: biological_process def: "The organization process that preserves a microtubule bundle in a stable functional or structural state." [PMID:18061564] is_a: GO:0043954 ! cellular component maintenance created_by: dph creation_date: 2019-12-09T19:10:30Z [Term] id: GO:0062196 name: regulation of lysosome size namespace: biological_process def: "Any process that modulates the size of a lysosome." [PMID:31314175] is_a: GO:0032535 ! regulation of cellular component size created_by: dph creation_date: 2019-12-09T21:06:44Z [Term] id: GO:0062197 name: cellular response to chemical stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus created_by: dph creation_date: 2019-12-10T14:42:03Z [Term] id: GO:0062198 name: rDNA replication pause site heterochromatin namespace: cellular_component def: "A region of heterochromatin associated with sites in rDNA repeats where replication forks pause." [PMID:25417108] is_a: GO:0098687 ! chromosomal region created_by: dph creation_date: 2019-12-11T20:32:24Z [Term] id: GO:0062199 name: chromosome, centromeric inner repeat region namespace: cellular_component def: "The portion of the centromeric region of a chromosome that contains the inner inverted repeat region of a modular centromere and part of the central core surrounding a non-conserved central region. This region is adjacent to the central core, on each chromosome arm." [PMID:21437270] synonym: "chromosome, centric outer repeat region" RELATED [] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0000775 ! chromosome, centromeric region created_by: dph creation_date: 2019-12-11T20:38:14Z [Term] id: GO:0062200 name: RAM/MOR signaling pathway namespace: biological_process def: "An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase." [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372] synonym: "MOR signaling pathway" NARROW [] synonym: "morphogenesis Orb6 network" EXACT [] synonym: "RAM signaling pathway" NARROW [] is_a: GO:0035556 ! intracellular signal transduction created_by: dph creation_date: 2019-12-17T20:21:12Z [Term] id: GO:0065001 name: specification of axis polarity namespace: biological_process def: "The pattern specification process in which the polarity of a body or organ axis is established and maintained." [GOC:mah] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009798 ! axis specification [Term] id: GO:0065002 name: intracellular protein transmembrane transport namespace: biological_process def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "intracellular membrane translocation of a protein" EXACT [] synonym: "intracellular protein membrane transport" EXACT [] synonym: "intracellular protein transport across a membrane" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0065004 name: protein-DNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] synonym: "DNA-protein complex assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0065005 name: protein-lipid complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle [Term] id: GO:0070001 name: aspartic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070002 name: glutamic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070003 name: threonine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0070004 name: cysteine-type exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] is_a: GO:0008234 ! cysteine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0070005 name: cysteine-type aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] xref: EC:3.4.18 is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0070004 ! cysteine-type exopeptidase activity [Term] id: GO:0070006 name: metalloaminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0070007 name: glutamic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070002 ! glutamic-type peptidase activity [Term] id: GO:0070008 name: serine-type exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE, ISBN:0716720094] xref: EC:3.4.21 is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0070009 name: serine-type aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0070010 name: peptidase activity, acting on D-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070011 name: peptidase activity, acting on L-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070012 name: oligopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] subset: goslim_mouse is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043229 ! intracellular organelle relationship: part_of GO:0043229 ! intracellular organelle [Term] id: GO:0070014 name: sucrase-isomaltase complex namespace: cellular_component def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777] synonym: "oligo-1,6-glucosidase complex" RELATED [] xref: Wikipedia:Sucrase-isomaltase is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1902687 ! glucosidase complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0070016 name: armadillo repeat domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225] synonym: "Arm repeat domain binding" EXACT [] synonym: "armadillo domain binding" EXACT [] synonym: "armadillo repeat binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070017 name: alphav-beta3 integrin-thrombospondin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219] synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070018 name: obsolete transforming growth factor beta type I receptor homodimeric complex namespace: cellular_component def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:R-HSA-170864] comment: This term was made obsolete because it does not represent a physiological complex, see https://github.com/geneontology/go-ontology/issues/12676 synonym: "TGF-beta type I receptor complex" EXACT [] synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:R-HSA-170864] synonym: "TGFBR1 homodimer" EXACT [Reactome:R-HSA-170864] synonym: "transforming growth factor beta type I receptor complex" EXACT [GOC:bf] is_obsolete: true [Term] id: GO:0070019 name: obsolete transforming growth factor beta type II receptor homodimeric complex namespace: cellular_component def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:R-HSA-170866] comment: This term was made obsolete because it does not represent a physiological complex, see https://github.com/geneontology/go-ontology/issues/12676 synonym: "TGF-beta type II receptor complex" EXACT [] synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:R-HSA-170866] synonym: "TGFBR2 homodimer" EXACT [Reactome:R-HSA-170866] synonym: "transforming growth factor beta type II receptor complex" EXACT [GOC:bf] is_obsolete: true [Term] id: GO:0070020 name: obsolete transforming growth factor beta1-type II receptor complex namespace: cellular_component def: "OBSOLETE. A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:R-HSA-170865] comment: This term was made obsolete because it does not represent a physiological complex, see https://github.com/geneontology/go-ontology/issues/12676 synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT [] synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:R-HSA-170865] is_obsolete: true [Term] id: GO:0070021 name: transforming growth factor beta ligand-receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand." [Reactome:R-HSA-170840] synonym: "TGF-beta 1:type II receptor:type I receptor complex" NARROW [Reactome:R-HSA-170840] synonym: "TGF-beta ligand-receptor complex" EXACT [] synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" NARROW [] synonym: "TGF-beta1 ligand-receptor complex" NARROW [] synonym: "TGF-beta1-beta2 ligand-receptor complex" NARROW [] synonym: "TGF-beta1-type II receptor-type I receptor complex" NARROW [] synonym: "TGF-beta2 ligand-receptor complex" NARROW [] synonym: "TGFb ligand-receptor complex" EXACT [] synonym: "TGFbeta ligand-receptor complex" EXACT [] synonym: "TGFbeta1 ligand-receptor complex" NARROW [] synonym: "TGFbeta1-beta2 ligand-receptor complex" NARROW [] synonym: "TGFbeta2 ligand-receptor complex" NARROW [] synonym: "transforming growth factor beta1-type II receptor-type I receptor complex" NARROW [] is_a: GO:0098802 ! plasma membrane signaling receptor complex is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0070022 name: obsolete transforming growth factor beta receptor complex namespace: cellular_component def: "OBSOLETE. A homodimeric receptor complex that consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:R-HSA-170864, Reactome:R-HSA-170866] comment: This term was made obsolete because it does not represent a physiological complex, see https://github.com/geneontology/go-ontology/issues/12676 synonym: "TGF-beta receptor complex" BROAD [] synonym: "transforming growth factor beta receptor complex" EXACT [GOC:bf] is_obsolete: true [Term] id: GO:0070023 name: interleukin-12-interleukin-12 receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991] synonym: "IL12-IL12 receptor complex" EXACT [] synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070024 name: CD19-Vav-PIK3R1 complex namespace: cellular_component def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218] synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070025 name: carbon monoxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd] synonym: "CO binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] id: GO:0070026 name: nitric oxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with nitric oxide (NO)." [GOC:ecd] synonym: "nitrogen monoxide binding" EXACT [] synonym: "nitrosyl binding" EXACT [CHEBI:16480] synonym: "NO binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0070027 name: carbon monoxide sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd] is_a: GO:0070025 ! carbon monoxide binding is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0070028 name: obsolete regulation of transcription by carbon monoxide namespace: biological_process def: "OBSOLETE. Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of transcription by CO" EXACT [] is_obsolete: true [Term] id: GO:0070029 name: alphav-beta3 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190] synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070030 name: alphav-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829] synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070031 name: alphav-beta5 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829] synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070032 name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862] synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795] synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070033 name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862] synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796] synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070034 name: telomerase RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the telomerase RNA template." [GOC:krc, PMID:16884717] synonym: "TERC binding" RELATED [GOC:dph] is_a: GO:0003723 ! RNA binding [Term] id: GO:0070035 name: obsolete purine NTP-dependent helicase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo), therefore this term was an unnecessary grouping term. is_obsolete: true [Term] id: GO:0070036 name: obsolete GTP-dependent helicase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo). is_obsolete: true [Term] id: GO:0070037 name: rRNA (pseudouridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah] xref: Reactome:R-HSA-6790906 "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248" is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0070038 name: rRNA (pseudouridine-N3-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah] is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity [Term] id: GO:0070039 name: rRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah] xref: Reactome:R-HSA-6793096 "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370" xref: Reactome:R-HSA-6793122 "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145" is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity relationship: part_of GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0070040 name: rRNA (adenine-C2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA." [GOC:imk, PMID:20007606, PMID:20184321, PMID:21368151, PMID:21415317, PMID:21527678] xref: EC:2.1.1.192 xref: MetaCyc:RXN-11586 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0070041 name: rRNA (uridine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0070042 name: rRNA (uridine-N3-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah] is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0070043 name: rRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah] xref: Reactome:R-HSA-6790982 "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity relationship: part_of GO:0070476 ! rRNA (guanine-N7)-methylation [Term] id: GO:0070044 name: synaptobrevin 2-SNAP-25-syntaxin-1a complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] synonym: "Snap25-Stx1a-Vamp2 complex" NARROW [] synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998] synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841] synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070045 name: synaptobrevin 2-SNAP-25-syntaxin-2 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851] synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070046 name: synaptobrevin 2-SNAP-25-syntaxin-3 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852] synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070047 name: synaptobrevin 2-SNAP-25-syntaxin-4 complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853] synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070048 name: endobrevin-SNAP-25-syntaxin-1a complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854] synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070049 name: endobrevin-SNAP-25-syntaxin-2 complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855] synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070050 name: neuron cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] synonym: "neuron maintenance" EXACT [] is_a: GO:0019725 ! cellular homeostasis is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0070051 name: fibrinogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0070052 name: collagen V binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type V collagen trimer." [GOC:BHF, GOC:mah] is_a: GO:0005518 ! collagen binding [Term] id: GO:0070053 name: thrombospondin receptor activity namespace: molecular_function def: "Combining with thrombospondin and transmitting the signal to initiate a change in cell activity." [GOC:BHF, GOC:signaling, GOC:vk] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0070054 name: mRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process alt_id: GO:0061012 def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. synonym: "cytosolic mRNA splicing" RELATED [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0006397 ! mRNA processing [Term] id: GO:0070055 name: obsolete mRNA endonucleolytic cleavage involved in unfolded protein response namespace: biological_process def: "OBSOLETE. The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response." [GOC:bf, GOC:krc, GOC:mah, PMID:10357823] comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). synonym: "ERN1-mediated XBP-1 mRNA cleavage" RELATED [HGNC:3449] synonym: "HAC1 mRNA cleavage" NARROW [GOC:bf] synonym: "HAC1-type intron splice site recognition and cleavage" NARROW [] synonym: "IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:bf] synonym: "XBP1 mRNA cleavage" NARROW [GOC:bf] is_obsolete: true consider: GO:0036498 [Term] id: GO:0070056 name: prospore membrane leading edge namespace: cellular_component def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385] synonym: "forespore membrane leading edge" EXACT [] is_a: GO:0098589 ! membrane region relationship: part_of GO:0005628 ! prospore membrane [Term] id: GO:0070057 name: prospore membrane spindle pole body attachment site namespace: cellular_component def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385] synonym: "forespore membrane SPB attachment site" EXACT [] synonym: "forespore membrane spindle pole body attachment site" EXACT [] synonym: "prospore membrane SPB attachment site" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005628 ! prospore membrane [Term] id: GO:0070058 name: tRNA gene clustering namespace: biological_process def: "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0070059 name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] synonym: "apoptosis in response to endoplasmic reticulum stress" BROAD [] synonym: "apoptosis in response to ER stress" EXACT [] synonym: "apoptosis triggered by ER stress" EXACT [] synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT [] synonym: "ER stress-induced apoptosis" EXACT [] synonym: "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [] is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0097193 ! intrinsic apoptotic signaling pathway [Term] id: GO:0070060 name: 'de novo' actin filament nucleation namespace: biological_process def: "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841] synonym: "formin-mediated actin filament nucleation" NARROW [] synonym: "unbranched actin filament nucleation" RELATED [] is_a: GO:0045010 ! actin nucleation [Term] id: GO:0070061 name: fructose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0070062 name: extracellular exosome namespace: cellular_component def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] synonym: "exosome" EXACT [GOC:pr] synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0070063 name: RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0070064 name: proline-rich region binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0070065 name: cellubrevin-VAMP4-syntaxin-16 complex namespace: cellular_component def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875] synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070066 name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex namespace: cellular_component def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874] synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070067 name: syntaxin-6-syntaxin-16-Vti1a complex namespace: cellular_component def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070068 name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex namespace: cellular_component def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877] synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070069 name: cytochrome complex namespace: cellular_component def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0070070 name: proton-transporting V-type ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah] synonym: "V-ATPase assembly" RELATED [] synonym: "V-ATPase complex assembly" RELATED [] is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly [Term] id: GO:0070071 name: proton-transporting two-sector ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0070072 name: vacuolar proton-transporting V-type ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah] synonym: "V-ATPase assembly" BROAD [] synonym: "V-ATPase complex assembly" BROAD [] is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly [Term] id: GO:0070073 name: clustering of voltage-gated calcium channels namespace: biological_process def: "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325] synonym: "clustering of voltage gated calcium channels" EXACT [] synonym: "clustering of voltage-dependent calcium channels" EXACT [] synonym: "voltage-gated calcium channel clustering" EXACT [] is_a: GO:0045161 ! neuronal ion channel clustering [Term] id: GO:0070074 name: mononeme namespace: cellular_component def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0070075 name: tear secretion namespace: biological_process def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0070076 name: histone lysine demethylation namespace: biological_process def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah] is_a: GO:0016577 ! histone demethylation [Term] id: GO:0070077 name: histone arginine demethylation namespace: biological_process def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah] is_a: GO:0016577 ! histone demethylation [Term] id: GO:0070078 name: histone H3-R2 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:BHF, GOC:vk] is_a: GO:0070077 ! histone arginine demethylation [Term] id: GO:0070079 name: histone H4-R3 demethylation namespace: biological_process def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:BHF, GOC:vk] is_a: GO:0070077 ! histone arginine demethylation [Term] id: GO:0070080 name: titin Z domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129] synonym: "Z repeat domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070081 name: clathrin-sculpted monoamine transport vesicle namespace: cellular_component def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2] synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle" EXACT [] synonym: "clathrin sculpted monoamine transport vesicle" EXACT [GOC:sl] is_a: GO:0030133 ! transport vesicle is_a: GO:0060198 ! clathrin-sculpted vesicle [Term] id: GO:0070082 name: clathrin-sculpted monoamine transport vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle." [GOC:mg2] synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen" EXACT [] synonym: "clathrin sculpted monoamine transport vesicle lumen" EXACT [GOC:sl] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle [Term] id: GO:0070083 name: clathrin-sculpted monoamine transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle." [GOC:mg2] synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "clathrin sculpted monoamine transport vesicle membrane" EXACT [GOC:sl] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle [Term] id: GO:0070084 name: protein initiator methionine removal namespace: biological_process def: "The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah] synonym: "removal of initiator methionine from protein" EXACT [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0070085 name: glycosylation namespace: biological_process def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah] xref: Wikipedia:Glycosylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0070086 name: ubiquitin-dependent endocytosis namespace: biological_process def: "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540] synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp] is_a: GO:0006897 ! endocytosis is_a: GO:0015031 ! protein transport is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0070087 name: chromo shadow domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093] synonym: "chromoshadow domain binding" EXACT [GOC:vk] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070088 name: PHA granule namespace: cellular_component def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612] synonym: "PHB granule" NARROW [] synonym: "polyhydroxyalkanoate granule" EXACT [] is_a: GO:0016234 ! inclusion body is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0070089 name: chloride-activated potassium channel activity namespace: molecular_function def: "Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0070090 name: metaphase plate namespace: cellular_component def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0070091 name: glucagon secretion namespace: biological_process def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070092 name: regulation of glucagon secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070091 ! glucagon secretion relationship: regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070093 name: negative regulation of glucagon secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "down regulation of glucagon secretion" EXACT [] synonym: "down-regulation of glucagon secretion" EXACT [] synonym: "downregulation of glucagon secretion" EXACT [] synonym: "inhibition of glucagon secretion" NARROW [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070091 ! glucagon secretion relationship: negatively_regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070094 name: positive regulation of glucagon secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] synonym: "activation of glucagon secretion" NARROW [] synonym: "stimulation of glucagon secretion" NARROW [] synonym: "up regulation of glucagon secretion" EXACT [] synonym: "up-regulation of glucagon secretion" EXACT [] synonym: "upregulation of glucagon secretion" EXACT [] is_a: GO:0070092 ! regulation of glucagon secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070091 ! glucagon secretion relationship: positively_regulates GO:0070091 ! glucagon secretion [Term] id: GO:0070095 name: fructose-6-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with fructose 6-phosphate." [GOC:mah] synonym: "D-fructose 6-phosphate binding" NARROW [] synonym: "fructose 6-phosphate binding" EXACT [] is_a: GO:0043168 ! anion binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0070096 name: mitochondrial outer membrane translocase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk] synonym: "TOM complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007008 ! outer mitochondrial membrane organization [Term] id: GO:0070097 name: delta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the delta subunit of the catenin complex." [GOC:rph] is_a: GO:0005515 ! protein binding [Term] id: GO:0070098 name: chemokine-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:1990869 ! cellular response to chemokine [Term] id: GO:0070099 name: regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070098 ! chemokine-mediated signaling pathway relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070100 name: negative regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070101 name: positive regulation of chemokine-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway [Term] id: GO:0070102 name: interleukin-6-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] synonym: "IL-6-mediated signaling pathway" RELATED [] synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071354 ! cellular response to interleukin-6 [Term] id: GO:0070103 name: regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070102 ! interleukin-6-mediated signaling pathway relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070104 name: negative regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070105 name: positive regulation of interleukin-6-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway [Term] id: GO:0070106 name: interleukin-27-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070107 name: regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070106 ! interleukin-27-mediated signaling pathway relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070108 name: negative regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070109 name: positive regulation of interleukin-27-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway [Term] id: GO:0070110 name: ciliary neurotrophic factor receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0070111 name: organellar chromatophore namespace: cellular_component def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055] synonym: "Paulinella-type chromatophore" EXACT [] is_a: GO:0043660 ! bacteroid-containing symbiosome [Term] id: GO:0070112 name: organellar chromatophore membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070113 name: organellar chromatophore inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah] is_a: GO:0070112 ! organellar chromatophore membrane [Term] id: GO:0070114 name: organellar chromatophore outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah] is_a: GO:0043661 ! peribacteroid membrane is_a: GO:0070112 ! organellar chromatophore membrane [Term] id: GO:0070115 name: organellar chromatophore intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070116 name: organellar chromatophore thylakoid namespace: cellular_component def: "A thylakoid located in an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah] is_a: GO:0009579 ! thylakoid relationship: part_of GO:0070111 ! organellar chromatophore [Term] id: GO:0070117 name: organellar chromatophore thylakoid lumen namespace: cellular_component def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah] synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah] is_a: GO:0031977 ! thylakoid lumen relationship: part_of GO:0070116 ! organellar chromatophore thylakoid [Term] id: GO:0070118 name: organellar chromatophore thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah] synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah] is_a: GO:0042651 ! thylakoid membrane relationship: part_of GO:0070116 ! organellar chromatophore thylakoid [Term] id: GO:0070119 name: ciliary neurotrophic factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah] synonym: "CNTF binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0070120 name: ciliary neurotrophic factor-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah] synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah] synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl] is_a: GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0070121 name: Kupffer's vesicle development namespace: biological_process def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh] synonym: "KV development" EXACT [GOC:dgh] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0070122 name: isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, http://128.240.24.212/cgi-bin/omd?isopeptide+bond] is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070123 name: transforming growth factor beta receptor activity, type III namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503] synonym: "betaglycan" NARROW [] synonym: "endoglin" NARROW [] synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] synonym: "type III TGF-beta receptor activity" EXACT [] synonym: "type III TGFbeta receptor activity" EXACT [] synonym: "type III transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity [Term] id: GO:0070124 name: mitochondrial translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] synonym: "mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070125 name: mitochondrial translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] synonym: "mitochondrial translation elongation" EXACT [GOC:mah] is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070126 name: mitochondrial translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria] synonym: "mitochondrial translation termination" EXACT [GOC:mah] is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070127 name: tRNA aminoacylation for mitochondrial protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006418 ! tRNA aminoacylation for protein translation relationship: part_of GO:0032543 ! mitochondrial translation [Term] id: GO:0070129 name: regulation of mitochondrial translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0006417 ! regulation of translation is_a: GO:0062125 ! regulation of mitochondrial gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032543 ! mitochondrial translation relationship: regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070130 name: negative regulation of mitochondrial translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032543 ! mitochondrial translation relationship: negatively_regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070131 name: positive regulation of mitochondrial translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032543 ! mitochondrial translation relationship: positively_regulates GO:0032543 ! mitochondrial translation [Term] id: GO:0070132 name: regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070124 ! mitochondrial translational initiation relationship: regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070133 name: negative regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:0070130 ! negative regulation of mitochondrial translation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070124 ! mitochondrial translational initiation relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070134 name: positive regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:0070131 ! positive regulation of mitochondrial translation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070124 ! mitochondrial translational initiation relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation [Term] id: GO:0070135 name: beta-1,2-oligomannoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0070136 name: beta-1,2-oligomannoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah] synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah] is_a: GO:0046354 ! mannan biosynthetic process is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process [Term] id: GO:0070137 name: ubiquitin-like protein-specific endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah] synonym: "small conjugating protein-specific endopeptidase activity" EXACT [] is_a: GO:0004197 ! cysteine-type endopeptidase activity is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0070138 name: ubiquitin-like protein-specific isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah] synonym: "small conjugating protein-specific isopeptidase activity" EXACT [GOC:dph] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity is_a: GO:0070122 ! isopeptidase activity [Term] id: GO:0070139 name: SUMO-specific endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah] xref: Reactome:R-HSA-2990840 "SENP1,2,5 proteolytically process SUMO1" xref: Reactome:R-HSA-2990842 "SEN1,2,5 proteolytically process SUMO2" xref: Reactome:R-HSA-2993763 "SENP1,2,5 proteolytically process SUMO3" is_a: GO:0016929 ! SUMO-specific protease activity is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity [Term] id: GO:0070140 name: SUMO-specific isopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah] is_a: GO:0016929 ! SUMO-specific protease activity is_a: GO:0070138 ! ubiquitin-like protein-specific isopeptidase activity [Term] id: GO:0070141 name: response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:BHF, GOC:mah] synonym: "response to UV-A light stimulus" EXACT [] synonym: "response to UV-A radiation stimulus" EXACT [] synonym: "response to UVA light stimulus" EXACT [] synonym: "response to UVA radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0070142 name: synaptic vesicle budding namespace: biological_process def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah] is_a: GO:0006900 ! vesicle budding from membrane relationship: part_of GO:0048489 ! synaptic vesicle transport [Term] id: GO:0070143 name: mitochondrial alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006419 ! alanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006419 ! alanyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070144 name: mitochondrial arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006420 ! arginyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006420 ! arginyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070145 name: mitochondrial asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006421 ! asparaginyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070146 name: mitochondrial aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006422 ! aspartyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006422 ! aspartyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070147 name: mitochondrial cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006423 ! cysteinyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070148 name: mitochondrial glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006425 ! glutaminyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070149 name: mitochondrial glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006424 ! glutamyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006424 ! glutamyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070150 name: mitochondrial glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006426 ! glycyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006426 ! glycyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070151 name: mitochondrial histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006427 ! histidyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006427 ! histidyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070152 name: mitochondrial isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006428 ! isoleucyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070153 name: mitochondrial leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006429 ! leucyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006429 ! leucyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070154 name: mitochondrial lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006430 ! lysyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006430 ! lysyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070155 name: mitochondrial methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006431 ! methionyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006431 ! methionyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070156 name: mitochondrial phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006432 ! phenylalanyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070157 name: mitochondrial prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006433 ! prolyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006433 ! prolyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070158 name: mitochondrial seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006434 ! seryl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006434 ! seryl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070159 name: mitochondrial threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006435 ! threonyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006435 ! threonyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070160 name: tight junction namespace: cellular_component def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] synonym: "occluding cell junction" EXACT [GOC:mah] synonym: "occluding junction" EXACT [GOC:mah] xref: Wikipedia:Tight_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0070161 name: anchoring junction namespace: cellular_component def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] synonym: "anchoring cell junction" EXACT [GOC:mah] is_a: GO:0030054 ! cell junction [Term] id: GO:0070162 name: adiponectin secretion namespace: biological_process def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl] is_a: GO:0009306 ! protein secretion is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0070163 name: regulation of adiponectin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:mah] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070162 ! adiponectin secretion relationship: regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070164 name: negative regulation of adiponectin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah] synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah] synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070163 ! regulation of adiponectin secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070162 ! adiponectin secretion relationship: negatively_regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070165 name: positive regulation of adiponectin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah] synonym: "activation of adiponectin secretion" NARROW [GOC:mah] synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah] synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah] synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070163 ! regulation of adiponectin secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070162 ! adiponectin secretion relationship: positively_regulates GO:0070162 ! adiponectin secretion [Term] id: GO:0070166 name: enamel mineralization namespace: biological_process def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346] synonym: "enamel formation" RELATED [PMID:16931858] is_a: GO:0034505 ! tooth mineralization relationship: part_of GO:0097186 ! amelogenesis [Term] id: GO:0070167 name: regulation of biomineral tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:0110149 ! regulation of biomineralization is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031214 ! biomineral tissue development relationship: regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070168 name: negative regulation of biomineral tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070167 ! regulation of biomineral tissue development is_a: GO:0110150 ! negative regulation of biomineralization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031214 ! biomineral tissue development relationship: negatively_regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070169 name: positive regulation of biomineral tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070167 ! regulation of biomineral tissue development is_a: GO:0110151 ! positive regulation of biomineralization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031214 ! biomineral tissue development relationship: positively_regulates GO:0031214 ! biomineral tissue development [Term] id: GO:0070170 name: regulation of tooth mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0042481 ! regulation of odontogenesis is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034505 ! tooth mineralization relationship: regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070171 name: negative regulation of tooth mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0042483 ! negative regulation of odontogenesis is_a: GO:0070168 ! negative regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034505 ! tooth mineralization relationship: negatively_regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070172 name: positive regulation of tooth mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] is_a: GO:0042482 ! positive regulation of odontogenesis is_a: GO:0070169 ! positive regulation of biomineral tissue development is_a: GO:0070170 ! regulation of tooth mineralization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034505 ! tooth mineralization relationship: positively_regulates GO:0034505 ! tooth mineralization [Term] id: GO:0070173 name: regulation of enamel mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth is_a: GO:0070170 ! regulation of tooth mineralization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070166 ! enamel mineralization relationship: regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070174 name: negative regulation of enamel mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0042489 ! negative regulation of odontogenesis of dentin-containing tooth is_a: GO:0070171 ! negative regulation of tooth mineralization is_a: GO:0070173 ! regulation of enamel mineralization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070166 ! enamel mineralization relationship: negatively_regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070175 name: positive regulation of enamel mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth is_a: GO:0070172 ! positive regulation of tooth mineralization is_a: GO:0070173 ! regulation of enamel mineralization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070166 ! enamel mineralization relationship: positively_regulates GO:0070166 ! enamel mineralization [Term] id: GO:0070176 name: DRM complex namespace: cellular_component def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059] synonym: "DP/Rb/MuvB" EXACT [PMID:17075059] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0070177 name: contractile vacuole discharge namespace: biological_process def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671] is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0070178 name: D-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah] synonym: "D-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0070179 name: D-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah] synonym: "D-serine anabolism" EXACT [] synonym: "D-serine biosynthesis" EXACT [] synonym: "D-serine formation" EXACT [] synonym: "D-serine synthesis" EXACT [] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0046437 ! D-amino acid biosynthetic process is_a: GO:0070178 ! D-serine metabolic process [Term] id: GO:0070180 name: large ribosomal subunit rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] synonym: "25S rRNA binding" EXACT [GOC:elh] synonym: "LSU rRNA binding" EXACT [] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0070181 name: small ribosomal subunit rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh] synonym: "18S rRNA binding" EXACT [GOC:elh] synonym: "SSU rRNA binding" EXACT [] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0070182 name: DNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA polymerase." [GOC:BHF, GOC:mah] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0070183 name: mitochondrial tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006436 ! tryptophanyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070184 name: mitochondrial tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006437 ! tyrosyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070185 name: mitochondrial valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] is_a: GO:0006438 ! valyl-tRNA aminoacylation is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation intersection_of: GO:0006438 ! valyl-tRNA aminoacylation intersection_of: occurs_in GO:0005739 ! mitochondrion [Term] id: GO:0070186 name: growth hormone activity namespace: molecular_function def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442] synonym: "GH activity" EXACT [PMID:11445442] synonym: "pituitary growth hormone activity" NARROW [GOC:vk] synonym: "placental growth hormone activity" NARROW [GOC:vk] is_a: GO:0005179 ! hormone activity [Term] id: GO:0070187 name: shelterin complex namespace: cellular_component def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880] synonym: "Pot1 complex" EXACT [GOC:vw] synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw] synonym: "telosome" EXACT [GOC:mah, GOC:vw] is_a: GO:0000783 ! nuclear telomere cap complex [Term] id: GO:0070188 name: obsolete Stn1-Ten1 complex namespace: cellular_component def: "OBSOLETE. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932] comment: This term was made obsolete because it was inaccurate. is_obsolete: true replaced_by: GO:1990879 [Term] id: GO:0070189 name: kynurenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph] synonym: "kynurenine metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0070190 name: obsolete inositol hexakisphosphate 1-kinase or 3-kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] comment: This term was made obsolete because it represents two reactions, and should be two separate terms. synonym: "inositol hexakisphosphate 1-kinase or 3-kinase activity" EXACT [] is_obsolete: true consider: GO:0052723 consider: GO:0052724 [Term] id: GO:0070191 name: methionine-R-sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972] is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0070193 name: synaptonemal complex organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah] synonym: "synaptonemal complex organisation" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0070194 name: synaptonemal complex disassembly namespace: biological_process def: "The controlled breakdown of a synaptonemal complex." [GOC:mah] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0070193 ! synaptonemal complex organization [Term] id: GO:0070195 name: growth hormone receptor complex namespace: cellular_component def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442] is_a: GO:0043235 ! receptor complex [Term] id: GO:0070196 name: eukaryotic translation initiation factor 3 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah] synonym: "eIF-3 assembly" EXACT [GOC:mah] synonym: "eIF3 assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0070197 name: meiotic attachment of telomere to nuclear envelope namespace: biological_process def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742] synonym: "attachment of telomeres to nuclear envelope" BROAD [] synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD [] synonym: "attachment of telomeric heterochromatin to nuclear envelope" EXACT [] is_a: GO:0097240 ! chromosome attachment to the nuclear envelope is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0044821 ! meiotic telomere tethering at nuclear periphery [Term] id: GO:0070198 name: protein localization to chromosome, telomeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah] synonym: "protein localization to telomere" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome [Term] id: GO:0070199 name: establishment of protein localization to chromosome namespace: biological_process def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0070200 name: establishment of protein localization to telomere namespace: biological_process def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to telomere" EXACT [GOC:mah] synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah] is_a: GO:0070198 ! protein localization to chromosome, telomeric region is_a: GO:0070199 ! establishment of protein localization to chromosome [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045184 ! establishment of protein localization relationship: regulates GO:0045184 ! establishment of protein localization [Term] id: GO:0070202 name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070199 ! establishment of protein localization to chromosome relationship: regulates GO:0070199 ! establishment of protein localization to chromosome [Term] id: GO:0070203 name: regulation of establishment of protein localization to telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to telomere" EXACT [GOC:mah] is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070200 ! establishment of protein localization to telomere relationship: regulates GO:0070200 ! establishment of protein localization to telomere [Term] id: GO:0070204 name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2)." [EC:2.2.1.9, RHEA:25593] comment: Note that this function was formerly EC:4.1.3.18. synonym: "MenD" RELATED [EC:2.2.1.9] synonym: "SEPHCHC synthase activity" EXACT [EC:2.2.1.9] xref: EC:2.2.1.9 xref: KEGG_REACTION:R08165 xref: MetaCyc:2.5.1.64-RXN xref: RHEA:25593 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0070205 name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, RHEA:25597] synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:4.2.99.20] synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:4.2.99.20] synonym: "MenH" RELATED [EC:4.2.99.20] synonym: "SHCHC synthase activity" EXACT [EC:4.2.99.20] synonym: "YfbB" RELATED [EC:4.2.99.20] xref: EC:4.2.99.20 xref: KEGG_REACTION:R08166 xref: MetaCyc:RXN-9310 xref: RHEA:25597 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0070206 name: protein trimerization namespace: biological_process def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd] synonym: "protein trimer assembly" EXACT [GOC:hjd] synonym: "protein trimer biosynthesis" EXACT [GOC:hjd] synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein trimer formation" EXACT [GOC:hjd] is_a: GO:0051259 ! protein complex oligomerization [Term] id: GO:0070207 name: protein homotrimerization namespace: biological_process def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd] synonym: "protein homotrimer assembly" EXACT [GOC:hjd] synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd] synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein homotrimer formation" EXACT [GOC:hjd] is_a: GO:0051260 ! protein homooligomerization is_a: GO:0070206 ! protein trimerization [Term] id: GO:0070208 name: protein heterotrimerization namespace: biological_process def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd] synonym: "protein heterotrimer assembly" EXACT [GOC:hjd] synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd] synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd] synonym: "protein heterotrimer formation" EXACT [GOC:hjd] is_a: GO:0051291 ! protein heterooligomerization is_a: GO:0070206 ! protein trimerization [Term] id: GO:0070209 name: ASTRA complex namespace: cellular_component def: "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:0110078 ! TTT complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0070210 name: Rpd3L-Expanded complex namespace: cellular_component def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720] synonym: "Clr6-LE complex" EXACT [GOC:vw] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0070211 name: Snt2C complex namespace: cellular_component def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0070212 name: protein poly-ADP-ribosylation namespace: biological_process def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379] synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl] synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl] synonym: "protein amino acid poly-ADP-ribosylation" EXACT [GOC:bf] synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl] synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl] is_a: GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0070213 name: protein auto-ADP-ribosylation namespace: biological_process def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl] synonym: "protein amino acid auto-ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0070214 name: CSK-GAP-A.p62 complex namespace: cellular_component def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0070215 name: obsolete MDM2 binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "MDM2 binding" EXACT [] is_obsolete: true replaced_by: GO:0097371 [Term] id: GO:0070216 name: obsolete MDM4 binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "MDM4 binding" EXACT [] synonym: "MDMX binding" EXACT [GOC:nln] is_obsolete: true replaced_by: GO:0097371 [Term] id: GO:0070217 name: transcription factor TFIIIB complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah] synonym: "TFIIIB assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0070218 name: sulfide ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell." [GOC:mah] synonym: "sulfide generation" RELATED [GOC:mah] synonym: "sulfide homeostasis" EXACT [GOC:mah] synonym: "sulfide production" RELATED [GOC:mah] synonym: "sulphide generation" RELATED [GOC:mah] synonym: "sulphide homeostasis" EXACT [GOC:mah] synonym: "sulphide ion homeostasis" EXACT [GOC:mah] synonym: "sulphide production" RELATED [GOC:mah] is_a: GO:0055083 ! monovalent inorganic anion homeostasis is_a: GO:0072505 ! divalent inorganic anion homeostasis [Term] id: GO:0070219 name: cellular sulfide ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell." [GOC:mah] synonym: "cellular sulfide homeostasis" EXACT [GOC:mah] synonym: "cellular sulphide homeostasis" EXACT [GOC:mah] synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah] is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0070218 ! sulfide ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis [Term] id: GO:0070220 name: aerobic sulfur oxidation namespace: biological_process def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY] synonym: "aerobic sulphur oxidation" EXACT [GOC:mah] xref: MetaCyc:SULFUROX-PWY is_a: GO:0019417 ! sulfur oxidation [Term] id: GO:0070221 name: sulfide oxidation, using sulfide:quinone oxidoreductase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY] synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY] synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah] xref: MetaCyc:P222-PWY is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070222 name: sulfide oxidation, using sulfide dehydrogenase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274] synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah] xref: MetaCyc:PWY-5274 is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070223 name: sulfide oxidation, using sulfur dioxygenase namespace: biological_process def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285] synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah] xref: MetaCyc:PWY-5285 is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0070224 name: sulfide:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN] synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314] synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah] xref: MetaCyc:R17-RXN xref: Reactome:R-HSA-1614665 "SQR oxidizes sulfide to bound persulfide" is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] id: GO:0070225 name: sulfide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S0 + reduced cytochrome c." [MetaCyc:RXN-8156] synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156] synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah] xref: EC:1.8.2 xref: MetaCyc:RXN-8156 is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] id: GO:0070226 name: sulfur:ferric ion oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN] synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN] xref: MetaCyc:SULFFEOXIDO-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0070227 name: lymphocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "lymphocyte apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process [Term] id: GO:0070228 name: regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "regulation of lymphocyte apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070227 ! lymphocyte apoptotic process relationship: regulates GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0070229 name: negative regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of lymphocyte apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070227 ! lymphocyte apoptotic process relationship: negatively_regulates GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0070230 name: positive regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of lymphocyte apoptosis" NARROW [] synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070227 ! lymphocyte apoptotic process relationship: positively_regulates GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0070231 name: T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "T cell apoptosis" NARROW [] synonym: "T lymphocyte apoptosis" EXACT [GOC:add] synonym: "T-cell apoptosis" EXACT [GOC:add] synonym: "T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0070232 name: regulation of T cell apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "regulation of T cell apoptosis" NARROW [] synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070231 ! T cell apoptotic process relationship: regulates GO:0070231 ! T cell apoptotic process [Term] id: GO:0070233 name: negative regulation of T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of T cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "downregulation of T cell apoptosis" EXACT [GOC:add] synonym: "inhibition of T cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "negative regulation of T cell apoptosis" NARROW [] synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070231 ! T cell apoptotic process relationship: negatively_regulates GO:0070231 ! T cell apoptotic process [Term] id: GO:0070234 name: positive regulation of T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of T cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "positive regulation of T cell apoptosis" NARROW [] synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add] synonym: "stimulation of T cell apoptosis" NARROW [GOC:add] synonym: "up regulation of T cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "upregulation of T cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070231 ! T cell apoptotic process relationship: positively_regulates GO:0070231 ! T cell apoptotic process [Term] id: GO:0070235 name: regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "regulation of AICD" BROAD [GOC:add] synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0065008 ! regulation of biological quality is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006924 ! activation-induced cell death of T cells relationship: regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070236 name: negative regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "negative regulation of AICD" BROAD [GOC:add] synonym: "negative regulation of antigen-driven apoptosis" BROAD [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:0070235 ! regulation of activation-induced cell death of T cells intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006924 ! activation-induced cell death of T cells relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070237 name: positive regulation of activation-induced cell death of T cells namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "positive regulation of AICD" BROAD [GOC:add] synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add] synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add] synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add] synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:0070235 ! regulation of activation-induced cell death of T cells intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006924 ! activation-induced cell death of T cells relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells [Term] id: GO:0070238 name: activated T cell autonomous cell death namespace: biological_process def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "ACAD" BROAD [GOC:add] synonym: "activated cell autonomous cell death" BROAD [GOC:add] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0070231 ! T cell apoptotic process relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0070239 name: regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that modulates the occurrence or rate of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of ACAD" BROAD [GOC:add] synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0065008 ! regulation of biological quality is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070238 ! activated T cell autonomous cell death relationship: regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070240 name: negative regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "negative regulation of ACAD" BROAD [GOC:add] synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:0070239 ! regulation of activated T cell autonomous cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070238 ! activated T cell autonomous cell death relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070241 name: positive regulation of activated T cell autonomous cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "positive regulation of ACAD" BROAD [GOC:add] synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add] synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add] synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add] synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add] synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:0070239 ! regulation of activated T cell autonomous cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070238 ! activated T cell autonomous cell death relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death [Term] id: GO:0070242 name: thymocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a thymocyte, an immature T cell located in the thymus." [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "immature T cell apoptosis" RELATED [GOC:add] synonym: "thymocyte apoptosis" NARROW [] is_a: GO:0070231 ! T cell apoptotic process [Term] id: GO:0070243 name: regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "regulation of thymocyte apoptosis" NARROW [] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070242 ! thymocyte apoptotic process relationship: regulates GO:0070242 ! thymocyte apoptotic process [Term] id: GO:0070244 name: negative regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "negative regulation of thymocyte apoptosis" NARROW [] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:0070243 ! regulation of thymocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070242 ! thymocyte apoptotic process relationship: negatively_regulates GO:0070242 ! thymocyte apoptotic process [Term] id: GO:0070245 name: positive regulation of thymocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). synonym: "activation of thymocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add] synonym: "positive regulation of thymocyte apoptosis" NARROW [] synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:0070243 ! regulation of thymocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070242 ! thymocyte apoptotic process relationship: positively_regulates GO:0070242 ! thymocyte apoptotic process [Term] id: GO:0070246 name: natural killer cell apoptotic process namespace: biological_process def: "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation." [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472] synonym: "natural killer cell apoptosis" NARROW [] synonym: "NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0070247 name: regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of natural killer cell apoptosis" NARROW [] synonym: "regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070246 ! natural killer cell apoptotic process relationship: regulates GO:0070246 ! natural killer cell apoptotic process [Term] id: GO:0070248 name: negative regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of natural killer cell apoptosis" NARROW [] synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process is_a: GO:0070247 ! regulation of natural killer cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070246 ! natural killer cell apoptotic process relationship: negatively_regulates GO:0070246 ! natural killer cell apoptotic process [Term] id: GO:0070249 name: positive regulation of natural killer cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of natural killer cell apoptosis" NARROW [] synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add] synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add] synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add] synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process is_a: GO:0070247 ! regulation of natural killer cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070246 ! natural killer cell apoptotic process relationship: positively_regulates GO:0070246 ! natural killer cell apoptotic process [Term] id: GO:0070250 name: mating projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp] synonym: "shmoo membrane" NARROW [GOC:jp] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0070251 name: pristanate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260] synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah] synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-389632 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate" is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0070252 name: actin-mediated cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement [Term] id: GO:0070253 name: somatostatin secretion namespace: biological_process def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070254 name: mucus secretion namespace: biological_process def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] synonym: "mucus production" EXACT [GOC:add] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0070255 name: regulation of mucus secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "regulation of mucus production" EXACT [GOC:add] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070254 ! mucus secretion relationship: regulates GO:0070254 ! mucus secretion [Term] id: GO:0070256 name: negative regulation of mucus secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "negative regulation of mucus production" EXACT [GOC:add] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070254 ! mucus secretion relationship: negatively_regulates GO:0070254 ! mucus secretion [Term] id: GO:0070257 name: positive regulation of mucus secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] synonym: "positive regulation of mucus production" EXACT [GOC:add] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070255 ! regulation of mucus secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070254 ! mucus secretion relationship: positively_regulates GO:0070254 ! mucus secretion [Term] id: GO:0070258 name: inner membrane pellicle complex namespace: cellular_component def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714] synonym: "inner membrane complex" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020039 ! pellicle [Term] id: GO:0070259 name: tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0070260 name: 5'-tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity [Term] id: GO:0070262 name: peptidyl-serine dephosphorylation namespace: biological_process def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf] is_a: GO:0006470 ! protein dephosphorylation [Term] id: GO:0070263 name: external side of fungal-type cell wall namespace: cellular_component def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah] is_a: GO:0010339 ! external side of cell wall relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0070264 name: transcription factor TFIIIE complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0070265 name: necrotic cell death namespace: biological_process def: "A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910] comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'. synonym: "cellular necrosis" EXACT [GOC:add] synonym: "necrosis" BROAD [GOC:mah] is_a: GO:0008219 ! cell death [Term] id: GO:0070266 name: necroptotic process namespace: biological_process alt_id: GO:0060553 alt_id: GO:0060554 alt_id: GO:0060555 def: "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097. synonym: "activation of necroptosis" RELATED [] synonym: "activation of necroptosis by extracellular signals" RELATED [] synonym: "activation of necroptosis in response to extracellular signals" RELATED [] synonym: "activation of necroptosis of activated-T cells" RELATED [] synonym: "establishment of necroptosis" RELATED [] synonym: "establishment of necroptosis of activated-T cells" RELATED [] synonym: "extracellular signal-induced necroptosis" RELATED [] synonym: "induction of necroptosis" BROAD [] synonym: "induction of necroptosis by extracellular signals" BROAD [] synonym: "induction of necroptosis of activated-T cells" BROAD [] synonym: "necroptosis" NARROW [] synonym: "PARP-dependent cell death" RELATED [] synonym: "parthanatos" RELATED [] synonym: "programmed necrosis" BROAD [Reactome:R-HSA-5213460.1] synonym: "programmed necrotic cell death" BROAD [GOC:mah] synonym: "RIPK1-mediated regulated necrosis" EXACT [Reactome:R-HSA-5213460.1] synonym: "TNF-induced necroptosis" NARROW [PMID:21876153] is_a: GO:0097300 ! programmed necrotic cell death [Term] id: GO:0070267 name: oncosis namespace: biological_process def: "A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107] comment: Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death. is_a: GO:0045793 ! positive regulation of cell size relationship: part_of GO:0070265 ! necrotic cell death [Term] id: GO:0070268 name: cornification namespace: biological_process def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [GOC:krc, PMID:18846107] is_a: GO:0012501 ! programmed cell death relationship: has_part GO:1903575 ! cornified envelope assembly relationship: part_of GO:0031424 ! keratinization [Term] id: GO:0070269 name: pyroptosis namespace: biological_process def: "A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18." [GOC:mtg_apoptosis, PMID:18846107, PMID:21760595] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0070270 name: obsolete mitotic catastrophe namespace: biological_process def: "OBSOLETE. A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107] comment: This term was made obsolete because it does not refer to a true process, but rather to the consequences of aberrations occurred during mitosis. synonym: "cell death occurring during metaphase" RELATED [PMID:18846107] synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107] synonym: "mitotic catastrophe" EXACT [] is_obsolete: true [Term] id: GO:0070271 name: obsolete protein complex biogenesis namespace: biological_process def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah] synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0070272 name: obsolete proton-transporting ATP synthase complex biogenesis namespace: biological_process def: "OBSOLETE. The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0070273 name: phosphatidylinositol-4-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0070274 name: RES complex namespace: cellular_component def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360] synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070275 name: aerobic ammonia oxidation to nitrite via pyruvic oxime namespace: biological_process def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242] xref: MetaCyc:PWY-2242 is_a: GO:0019329 ! ammonia oxidation [Term] id: GO:0070276 name: halogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [CHEBI:22473, GOC:mah] synonym: "halogen metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0070277 name: iodide oxidation namespace: biological_process def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN] is_a: GO:0055114 ! oxidation-reduction process is_a: GO:0070276 ! halogen metabolic process [Term] id: GO:0070278 name: extracellular matrix constituent secretion namespace: biological_process def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] synonym: "ECM constituent secretion" EXACT [GOC:mah] synonym: "ECM secretion" EXACT [GOC:mah] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0030198 ! extracellular matrix organization [Term] id: GO:0070279 name: vitamin B6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0070280 name: pyridoxal binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] is_a: GO:0043169 ! cation binding is_a: GO:0048037 ! cofactor binding is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0070281 name: pyridoxamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16410, GOC:mah] is_a: GO:0070279 ! vitamin B6 binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0070282 name: pyridoxine binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah] is_a: GO:0048037 ! cofactor binding is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0070284 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine." [PMID:18953358] synonym: "HMP-P synthase activity" EXACT [PMID:18953358] synonym: "ThiC" RELATED [PMID:18953358] is_a: GO:0016853 ! isomerase activity [Term] id: GO:0070285 name: pigment cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] is_a: GO:0048468 ! cell development relationship: part_of GO:0050931 ! pigment cell differentiation [Term] id: GO:0070286 name: axonemal dynein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621] synonym: "dynein arm assembly" EXACT [GOC:vk, PMID:19944405] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0035082 ! axoneme assembly [Term] id: GO:0070287 name: ferritin receptor activity namespace: molecular_function def: "Combining with ferritin, and delivering ferritin into the cell via endocytosis." [GOC:bf, PMID:17459943, PMID:19154717] synonym: "ferritin complex receptor activity" EXACT [GOC:mah] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0070288 name: ferritin complex namespace: cellular_component def: "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." [GOC:mah, PMID:19154717] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0070289 name: extracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717] synonym: "serum ferritin complex" RELATED [PMID:19154717] is_a: GO:0070288 ! ferritin complex relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0070290 name: N-acylphosphatidylethanolamine-specific phospholipase D activity namespace: molecular_function def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693] subset: goslim_chembl synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT [] synonym: "NAPE-specific phospholipase D activity" EXACT [] xref: EC:3.1.4.4 xref: Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0070291 name: N-acylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693] synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process [Term] id: GO:0070292 name: N-acylphosphatidylethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693] synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693] synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0070293 name: renal absorption namespace: biological_process def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:dph, GOC:mah, GOC:yaf] synonym: "nephron absorption" EXACT [GOC:mah] synonym: "renal reabsorption" EXACT [GOC:dph] is_a: GO:0003014 ! renal system process [Term] id: GO:0070294 name: renal sodium ion absorption namespace: biological_process def: "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah] synonym: "nephron sodium ion absorption" EXACT [GOC:mah] synonym: "renal sodium ion reabsorption" EXACT [GOC:dph] is_a: GO:0003096 ! renal sodium ion transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0070295 name: renal water absorption namespace: biological_process def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah] synonym: "nephron water absorption" EXACT [GOC:mah] synonym: "renal water reabsorption" EXACT [GOC:dph] is_a: GO:0003097 ! renal water transport is_a: GO:0070293 ! renal absorption [Term] id: GO:0070296 name: sarcoplasmic reticulum calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:BHF, GOC:vk] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0070297 name: regulation of phosphorelay signal transduction system namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "regulation of two-component signal transduction system" EXACT [GOC:bf, GOC:mah] synonym: "regulation of two-component signal transduction system (phosphorelay)" NARROW [] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000160 ! phosphorelay signal transduction system relationship: regulates GO:0000160 ! phosphorelay signal transduction system [Term] id: GO:0070298 name: negative regulation of phosphorelay signal transduction system namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah] synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah] synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "negative regulation of two-component signal transduction system (phosphorelay)" NARROW [] is_a: GO:0070297 ! regulation of phosphorelay signal transduction system is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000160 ! phosphorelay signal transduction system relationship: negatively_regulates GO:0000160 ! phosphorelay signal transduction system [Term] id: GO:0070299 name: positive regulation of phosphorelay signal transduction system namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] synonym: "activation of two-component signal transduction" NARROW [GOC:mah] synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] synonym: "positive regulation of two-component signal transduction system (phosphorelay)" NARROW [] synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah] synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah] synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah] is_a: GO:0070297 ! regulation of phosphorelay signal transduction system is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000160 ! phosphorelay signal transduction system relationship: positively_regulates GO:0000160 ! phosphorelay signal transduction system [Term] id: GO:0070300 name: phosphatidic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732] synonym: "phosphatidate binding" EXACT [GOC:jp] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0070301 name: cellular response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah] is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0035690 ! cellular response to drug is_a: GO:0042542 ! response to hydrogen peroxide is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097237 ! cellular response to toxic substance [Term] id: GO:0070302 name: regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070303 name: negative regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070304 name: positive regulation of stress-activated protein kinase signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT [] synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0070305 name: response to cGMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl] synonym: "response to 3',5' cGMP" EXACT [GOC:mah] synonym: "response to 3',5'-cGMP" EXACT [GOC:mah] synonym: "response to cyclic GMP" EXACT [GOC:mah] synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0070306 name: lens fiber cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735] synonym: "lens fibre cell differentiation" EXACT [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0002088 ! lens development in camera-type eye [Term] id: GO:0070307 name: lens fiber cell development namespace: biological_process def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "lens fibre cell development" EXACT [GOC:mah] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0070306 ! lens fiber cell differentiation [Term] id: GO:0070308 name: lens fiber cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "lens fibre cell fate commitment" EXACT [GOC:mah] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0070306 ! lens fiber cell differentiation [Term] id: GO:0070309 name: lens fiber cell morphogenesis namespace: biological_process def: "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk] synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah] synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye relationship: part_of GO:0070307 ! lens fiber cell development [Term] id: GO:0070310 name: ATR-ATRIP complex namespace: cellular_component def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280] synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343] synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070311 name: nucleosomal methylation activator complex namespace: cellular_component def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568] synonym: "NUMAC" EXACT [PMID:14729568] is_a: GO:0035097 ! histone methyltransferase complex [Term] id: GO:0070312 name: RAD52-ERCC4-ERCC1 complex namespace: cellular_component def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070313 name: RGS6-DNMT1-DMAP1 complex namespace: cellular_component def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070314 name: G1 to G0 transition namespace: biological_process def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194] synonym: "cell cycle quiescence" RELATED [GOC:mah] synonym: "establishment of cell quiescence" EXACT [GOC:mah] synonym: "G1/G0 transition" EXACT [GOC:mah] synonym: "stationary phase" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0070315 name: G1 to G0 transition involved in cell differentiation namespace: biological_process def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194] synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah] is_a: GO:0070314 ! G1 to G0 transition intersection_of: GO:0070314 ! G1 to G0 transition intersection_of: part_of GO:0030154 ! cell differentiation relationship: part_of GO:0030154 ! cell differentiation [Term] id: GO:0070316 name: regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045023 ! G0 to G1 transition relationship: regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070317 name: negative regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah] synonym: "maintenance of cell quiescence" EXACT [GOC:mah] synonym: "maintenance of G0 arrest" EXACT [GOC:mah] synonym: "maintenance of G0 phase" EXACT [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0070316 ! regulation of G0 to G1 transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045023 ! G0 to G1 transition relationship: negatively_regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070318 name: positive regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] is_a: GO:0070316 ! regulation of G0 to G1 transition is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045023 ! G0 to G1 transition relationship: positively_regulates GO:0045023 ! G0 to G1 transition [Term] id: GO:0070319 name: Golgi to plasma membrane transport vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "Golgi to plasma membrane constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah] is_a: GO:0070382 ! exocytic vesicle [Term] id: GO:0070320 name: inward rectifier potassium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah] is_a: GO:0019870 ! potassium channel inhibitor activity [Term] id: GO:0070321 name: regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0070322 name: negative regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation [Term] id: GO:0070323 name: positive regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah] synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah] synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation [Term] id: GO:0070324 name: thyroid hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph] subset: goslim_chembl synonym: "thyroxine binding" NARROW [GOC:mah] synonym: "triiodothyronine binding" NARROW [GOC:mah] is_a: GO:0042562 ! hormone binding [Term] id: GO:0070325 name: lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipoprotein particle receptor." [GOC:BHF, GOC:rl] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0070326 name: very-low-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah] synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl] synonym: "very-low-density lipoprotein receptor binding" EXACT [GOC:bf, GOC:dph] synonym: "VLDL receptor binding" EXACT [GOC:mah] synonym: "VLDLR binding" EXACT [GOC:mah] is_a: GO:0070325 ! lipoprotein particle receptor binding [Term] id: GO:0070327 name: thyroid hormone transport namespace: biological_process def: "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:rph] synonym: "thyroxine transport" NARROW [GOC:mah] synonym: "triiodothyronine transport" NARROW [GOC:mah] is_a: GO:0009914 ! hormone transport [Term] id: GO:0070328 name: triglyceride homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] synonym: "triacylglycerol homeostasis" EXACT [GOC:rl] is_a: GO:0055090 ! acylglycerol homeostasis [Term] id: GO:0070329 name: tRNA seleno-modification namespace: biological_process def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807] synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0006400 ! tRNA modification [Term] id: GO:0070330 name: aromatase activity namespace: molecular_function def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] synonym: "estrogen synthetase activity" NARROW [] xref: EC:1.14.14.1 xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0551 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0070331 name: CD20-Lck-Fyn complex namespace: cellular_component def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0070332 name: CD20-Lck-Lyn-Fyn complex namespace: cellular_component def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0070333 name: alpha6-beta4 integrin-Shc-Grb2 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090] synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070334 name: alpha6-beta4 integrin-laminin 5 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090] synonym: "alpha6-beta4 integrin-laminin-332 complex" EXACT [GOC:sl, PMID:15979864] synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070335 name: aspartate binding namespace: molecular_function def: "Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4." [CHEBI:29995, GOC:mah] synonym: "aspartic acid binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0070336 name: flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] is_a: GO:0003677 ! DNA binding [Term] id: GO:0070337 name: 3'-flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] is_a: GO:0070336 ! flap-structured DNA binding [Term] id: GO:0070338 name: 5'-flap-structured DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154] is_a: GO:0070336 ! flap-structured DNA binding [Term] id: GO:0070339 name: response to bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222] is_a: GO:0032493 ! response to bacterial lipoprotein [Term] id: GO:0070340 name: detection of bacterial lipopeptide namespace: biological_process def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222] is_a: GO:0042494 ! detection of bacterial lipoprotein is_a: GO:0070339 ! response to bacterial lipopeptide [Term] id: GO:0070341 name: fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] synonym: "adipocyte proliferation" EXACT [GOC:sl] synonym: "adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0070342 name: brown fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl] synonym: "brown adipocyte proliferation" EXACT [GOC:sl] synonym: "brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation [Term] id: GO:0070343 name: white fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl] synonym: "white adipocyte proliferation" EXACT [GOC:sl] synonym: "white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070341 ! fat cell proliferation [Term] id: GO:0070344 name: regulation of fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070341 ! fat cell proliferation relationship: regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070345 name: negative regulation of fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070341 ! fat cell proliferation relationship: negatively_regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070346 name: positive regulation of fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070341 ! fat cell proliferation relationship: positively_regulates GO:0070341 ! fat cell proliferation [Term] id: GO:0070347 name: regulation of brown fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070342 ! brown fat cell proliferation relationship: regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070348 name: negative regulation of brown fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070342 ! brown fat cell proliferation relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070349 name: positive regulation of brown fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070347 ! regulation of brown fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070342 ! brown fat cell proliferation relationship: positively_regulates GO:0070342 ! brown fat cell proliferation [Term] id: GO:0070350 name: regulation of white fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070343 ! white fat cell proliferation relationship: regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070351 name: negative regulation of white fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0070345 ! negative regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070343 ! white fat cell proliferation relationship: negatively_regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070352 name: positive regulation of white fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of white fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah] is_a: GO:0070346 ! positive regulation of fat cell proliferation is_a: GO:0070350 ! regulation of white fat cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070343 ! white fat cell proliferation relationship: positively_regulates GO:0070343 ! white fat cell proliferation [Term] id: GO:0070353 name: GATA1-TAL1-TCF3-Lmo2 complex namespace: cellular_component def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070354 name: GATA2-TAL1-TCF3-Lmo2 complex namespace: cellular_component def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070355 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227] synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247] synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070356 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227] synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244] synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070357 name: alphav-beta3 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831] synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070358 name: actin polymerization-dependent cell motility namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977] synonym: "cell motility by actin tail formation" EXACT [PMID:15773977] is_a: GO:0048870 ! cell motility [Term] id: GO:0070359 name: actin polymerization-dependent cell motility involved in migration of symbiont in host namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell." [GOC:jl, GOC:mah, PMID:15773977] synonym: "actin polymerization-dependent cell motility involved in migration of symbiont within host" EXACT [] is_a: GO:0070358 ! actin polymerization-dependent cell motility relationship: part_of GO:0070360 ! migration of symbiont within host by polymerization of host actin [Term] id: GO:0070360 name: migration of symbiont within host by polymerization of host actin namespace: biological_process def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah] is_a: GO:0044001 ! migration in host [Term] id: GO:0070365 name: hepatocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] synonym: "liver cell differentiation" EXACT [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001889 ! liver development [Term] id: GO:0070366 name: regulation of hepatocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070365 ! hepatocyte differentiation relationship: regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070367 name: negative regulation of hepatocyte differentiation namespace: biological_process def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070365 ! hepatocyte differentiation relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070368 name: positive regulation of hepatocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0070366 ! regulation of hepatocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070365 ! hepatocyte differentiation relationship: positively_regulates GO:0070365 ! hepatocyte differentiation [Term] id: GO:0070369 name: beta-catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402] synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402] is_a: GO:0071664 ! catenin-TCF7L2 complex is_a: GO:1990907 ! beta-catenin-TCF complex [Term] id: GO:0070370 name: cellular heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp] synonym: "cellular thermotolerance" EXACT [GOC:jp] is_a: GO:0010286 ! heat acclimation is_a: GO:0034605 ! cellular response to heat [Term] id: GO:0070371 name: ERK1 and ERK2 cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0121245462, ISBN:0896039986, PMID:20811974, PMID:28903453] comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases. synonym: "ERK cascade" BROAD [GOC:add] synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "ERK1 cascade" NARROW [GOC:add] synonym: "ERK1/2 cascade" EXACT [GOC:add] synonym: "ERK2 cascade" NARROW [GOC:add] synonym: "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974] synonym: "extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974] synonym: "MAPK1 cascade" NARROW [GOC:add] synonym: "MAPK3 cascade" NARROW [GOC:add] is_a: GO:0000165 ! MAPK cascade [Term] id: GO:0070372 name: regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "regulation of ERK cascade" BROAD [GOC:add] synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "regulation of ERK1 cascade" NARROW [GOC:add] synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "regulation of ERK2 cascade" NARROW [GOC:add] synonym: "regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "regulation of MAPK3 cascade" NARROW [GOC:add] is_a: GO:0043408 ! regulation of MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070371 ! ERK1 and ERK2 cascade relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070373 name: negative regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "negative regulation of ERK cascade" BROAD [GOC:add] synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add] synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add] synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add] is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070374 name: positive regulation of ERK1 and ERK2 cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah] synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "positive regulation of ERK cascade" BROAD [GOC:add] synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add] synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add] synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add] synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add] synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add] synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah] synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade [Term] id: GO:0070375 name: ERK5 cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0896039986, PMID:16376520, PMID:16880823, PMID:20811974, PMID:28903453] synonym: "big MAP kinase signaling cascade" EXACT [PMID:20811974] synonym: "BMK cascade" EXACT [PMID:20811974] synonym: "BMK signaling pathway" EXACT [GOC:mah] synonym: "BMK signalling pathway" EXACT [GOC:mah] synonym: "BMK1 cascade" EXACT [GOC:add] synonym: "ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974] synonym: "MAPK7 cascade" EXACT [GOC:add] is_a: GO:0000165 ! MAPK cascade [Term] id: GO:0070376 name: regulation of ERK5 cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "regulation of BMK cascade" EXACT [GOC:signaling] synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "regulation of BMK1 cascade" EXACT [GOC:add] synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "regulation of MAPK7 cascade" EXACT [GOC:add] is_a: GO:0043408 ! regulation of MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070375 ! ERK5 cascade relationship: regulates GO:0070375 ! ERK5 cascade [Term] id: GO:0070377 name: negative regulation of ERK5 cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] synonym: "down regulation of BMK cascade" EXACT [GOC:mah] synonym: "down-regulation of BMK cascade" EXACT [GOC:mah] synonym: "downregulation of BMK cascade" EXACT [GOC:mah] synonym: "inhibition of BMK cascade" NARROW [GOC:mah] synonym: "negative regulation of BMK cascade" EXACT [GOC:signaling] synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add] synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add] is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0070376 ! regulation of ERK5 cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070375 ! ERK5 cascade relationship: negatively_regulates GO:0070375 ! ERK5 cascade [Term] id: GO:0070378 name: positive regulation of ERK5 cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:mah] synonym: "activation of BMK cascade" NARROW [GOC:mah] synonym: "positive regulation of BMK cascade" EXACT [GOC:signaling] synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add] synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520] synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add] synonym: "stimulation of BMK cascade" NARROW [GOC:mah] synonym: "up regulation of BMK cascade" EXACT [GOC:mah] synonym: "up-regulation of BMK cascade" EXACT [GOC:mah] synonym: "upregulation of BMK cascade" EXACT [GOC:mah] is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0070376 ! regulation of ERK5 cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070375 ! ERK5 cascade relationship: positively_regulates GO:0070375 ! ERK5 cascade [Term] id: GO:0070379 name: high mobility group box 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461] synonym: "HMGB1 binding" EXACT [GOC:add] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0070380 name: high mobility group box 1 receptor activity namespace: molecular_function def: "Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, PMID:18431461] synonym: "HMGB1 receptor activity" EXACT [GOC:add] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0070379 ! high mobility group box 1 binding [Term] id: GO:0070381 name: endosome to plasma membrane transport vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576] synonym: "endosome to plasma membrane constitutive secretory pathway transport vesicle" EXACT [] synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah] is_a: GO:0070382 ! exocytic vesicle [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle is_a: GO:0099503 ! secretory vesicle [Term] id: GO:0070383 name: DNA cytosine deamination namespace: biological_process def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah] is_a: GO:0045006 ! DNA deamination [Term] id: GO:0070384 name: Harderian gland development namespace: biological_process def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104] comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages. is_a: GO:0048732 ! gland development [Term] id: GO:0070385 name: egasyn-beta-glucuronidase complex namespace: cellular_component def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0070386 name: procollagen-proline 4-dioxygenase complex, alpha(I) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822] synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070387 name: procollagen-proline 4-dioxygenase complex, alpha(II) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822] synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070388 name: procollagen-proline 4-dioxygenase complex, alpha(III) type namespace: cellular_component def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733] synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474] is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex [Term] id: GO:0070390 name: transcription export complex 2 namespace: cellular_component def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829] synonym: "Sac3-Thp1-Sus1-Sem1-Cdc31 complex" EXACT [PMID:17786152] synonym: "TREX-2 complex" EXACT [GOC:dgf] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070391 name: response to lipoteichoic acid namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "response to LTA" EXACT [GOC:add] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0070392 name: detection of lipoteichoic acid namespace: biological_process def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "detection of LTA" EXACT [GOC:add] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0070391 ! response to lipoteichoic acid [Term] id: GO:0070393 name: teichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680] synonym: "teichoic acid breakdown" EXACT [GOC:add] synonym: "teichoic acid catabolism" EXACT [GOC:add] synonym: "teichoic acid degradation" EXACT [GOC:add] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0046374 ! teichoic acid metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0070394 name: lipoteichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "lipoteichoic acid metabolism" EXACT [GOC:add] synonym: "LTA metabolic process" EXACT [GOC:add] is_a: GO:0046374 ! teichoic acid metabolic process [Term] id: GO:0070395 name: lipoteichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] synonym: "lipoteichoic acid anabolism" EXACT [GOC:add] synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add] synonym: "lipoteichoic acid formation" EXACT [GOC:add] synonym: "lipoteichoic acid synthesis" EXACT [GOC:add] synonym: "LTA biosynthetic process" BROAD [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:0070394 ! lipoteichoic acid metabolic process [Term] id: GO:0070396 name: lipoteichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680] synonym: "lipoteichoic acid breakdown" EXACT [GOC:add] synonym: "lipoteichoic acid catabolism" EXACT [GOC:add] synonym: "lipoteichoic acid degradation" EXACT [GOC:add] is_a: GO:0070393 ! teichoic acid catabolic process is_a: GO:0070394 ! lipoteichoic acid metabolic process [Term] id: GO:0070397 name: wall teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] synonym: "wall teichoic acid metabolism" EXACT [GOC:add] synonym: "WTA metabolic process" EXACT [GOC:add] is_a: GO:0046374 ! teichoic acid metabolic process [Term] id: GO:0070398 name: wall teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] synonym: "wall teichoic acid anabolism" EXACT [GOC:add] synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add] synonym: "wall teichoic acid formation" EXACT [GOC:add] synonym: "wall teichoic acid synthesis" EXACT [GOC:add] synonym: "WTA biosynthetic process" EXACT [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:0070397 ! wall teichoic acid metabolic process [Term] id: GO:0070399 name: wall teichoic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680] synonym: "wall teichoic acid breakdown" EXACT [GOC:add] synonym: "wall teichoic acid catabolism" EXACT [GOC:add] synonym: "wall teichoic acid degradation" EXACT [GOC:add] is_a: GO:0070397 ! wall teichoic acid metabolic process [Term] id: GO:0070400 name: teichoic acid D-alanylation namespace: biological_process def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688] synonym: "teichoic acid alanylation" EXACT [GOC:add] is_a: GO:0019350 ! teichoic acid biosynthetic process [Term] id: GO:0070401 name: NADP+ binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NADP (oxidized) binding" EXACT [GOC:mah] synonym: "NADP binding" RELATED [GOC:mah] synonym: "oxidized NADP binding" EXACT [GOC:mah] synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0050661 ! NADP binding [Term] id: GO:0070402 name: NADPH binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NADP (reduced) binding" EXACT [GOC:mah] synonym: "reduced NADP binding" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0050661 ! NADP binding [Term] id: GO:0070403 name: NAD+ binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NAD (oxidized) binding" EXACT [GOC:mah] synonym: "NAD binding" RELATED [GOC:mah] synonym: "oxidized NAD binding" EXACT [GOC:mah] synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0051287 ! NAD binding [Term] id: GO:0070404 name: NADH binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] synonym: "NAD (reduced) binding" EXACT [GOC:mah] synonym: "reduced NAD binding" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0051287 ! NAD binding [Term] id: GO:0070405 name: ammonium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd] synonym: "ammonium binding" RELATED [] is_a: GO:0043169 ! cation binding [Term] id: GO:0070406 name: glutamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamine, 2,5-diamino-5-oxopentanoic acid." [CHEBI:28300, GOC:ecd] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding [Term] id: GO:0070407 name: oxidation-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah] synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah] synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah] synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah] synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah] synonym: "oxidized protein catabolic process" EXACT [GOC:mah] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0070408 name: carbamoyl phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah] xref: UM-BBD_pathwayID:bzn is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0070409 name: carbamoyl phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] synonym: "carbamoyl phosphate anabolism" EXACT [] synonym: "carbamoyl phosphate biosynthesis" EXACT [] synonym: "carbamoyl phosphate formation" EXACT [] synonym: "carbamoyl phosphate synthesis" EXACT [] synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0070408 ! carbamoyl phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0070410 name: co-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] synonym: "common mediator SMAD binding" EXACT [GOC:rl] synonym: "common partner SMAD binding" EXACT [GOC:rl] synonym: "common-mediator SMAD binding" EXACT [GOC:rl] synonym: "common-partner SMAD binding" EXACT [GOC:rl] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070411 name: I-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070412 name: R-SMAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] synonym: "pathway restricted SMAD binding" EXACT [GOC:rl] synonym: "pathway-restricted SMAD binding" EXACT [GOC:rl] synonym: "receptor regulated SMAD binding" EXACT [GOC:rl] synonym: "receptor-regulated SMAD binding" EXACT [GOC:rl] is_a: GO:0046332 ! SMAD binding [Term] id: GO:0070413 name: trehalose metabolism in response to stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0005991 ! trehalose metabolic process intersection_of: GO:0005991 ! trehalose metabolic process intersection_of: part_of GO:0006950 ! response to stress relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0070414 name: trehalose metabolism in response to heat stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0070413 ! trehalose metabolism in response to stress relationship: part_of GO:0034605 ! cellular response to heat [Term] id: GO:0070415 name: trehalose metabolism in response to cold stress namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah] is_a: GO:0070413 ! trehalose metabolism in response to stress is_a: GO:0070417 ! cellular response to cold [Term] id: GO:0070416 name: trehalose metabolism in response to water deprivation namespace: biological_process def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333] synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah] is_a: GO:0070413 ! trehalose metabolism in response to stress intersection_of: GO:0005991 ! trehalose metabolic process intersection_of: part_of GO:0009414 ! response to water deprivation relationship: part_of GO:0009414 ! response to water deprivation [Term] id: GO:0070417 name: cellular response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp] synonym: "cellular response to cold stress" EXACT [GOC:jp] is_a: GO:0009409 ! response to cold is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0070418 name: DNA-dependent protein kinase complex namespace: cellular_component def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW [] synonym: "DNA-PK complex" EXACT [] synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355] is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070419 name: nonhomologous end joining complex namespace: cellular_component def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] synonym: "NHEJ complex" EXACT [GOC:mah] synonym: "non-homologous end joining complex" EXACT [GOC:mah] is_a: GO:1990391 ! DNA repair complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0070420 name: Ku-DNA ligase complex namespace: cellular_component def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628] is_a: GO:0070419 ! nonhomologous end joining complex [Term] id: GO:0070421 name: DNA ligase III-XRCC1 complex namespace: cellular_component def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070422 name: G-protein beta/gamma-Raf-1 complex namespace: cellular_component def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0070423 name: nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [Term] id: GO:0070424 name: regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway relationship: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070425 name: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "negative regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway relationship: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070426 name: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] synonym: "positive regulation of NOD signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway relationship: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070427 name: nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1)." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD1 signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070428 name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070429 name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070430 name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway [Term] id: GO:0070431 name: nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2)." [GOC:add, PMID:17944960, PMID:18585455] synonym: "NOD2 signaling pathway" EXACT [GOC:add] synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway [Term] id: GO:0070432 name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070433 name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070434 name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add] synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway [Term] id: GO:0070435 name: Shc-EGFR complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070436 name: Grb2-EGFR complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070437 name: Grb2-Shc complex namespace: cellular_component def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070438 name: obsolete mTOR-FKBP12-rapamycin complex namespace: cellular_component def: "OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus)." [GOC:sl, PMID:20005306, PMID:7822316] comment: This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally. synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987] synonym: "mTOR-FKBP12-rapamycin complex" EXACT [] is_obsolete: true [Term] id: GO:0070439 name: Mad-Max-mSin3A complex namespace: cellular_component def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0070440 name: Mad-Max-mSin3B complex namespace: cellular_component def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0070441 name: G-protein beta/gamma-Btk complex namespace: cellular_component def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615] synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0070442 name: integrin alphaIIb-beta3 complex namespace: cellular_component def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042] synonym: "alphaIIb-beta3 integrin complex" EXACT [] synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381] is_a: GO:0008305 ! integrin complex [Term] id: GO:0070443 name: Mad-Max complex namespace: cellular_component def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0070444 name: oligodendrocyte progenitor proliferation namespace: biological_process def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915] synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0070445 name: regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070444 ! oligodendrocyte progenitor proliferation relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070446 name: negative regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070447 name: positive regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation [Term] id: GO:0070448 name: laricitrin 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [MetaCyc:RXN-8452] comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149. synonym: "CrCOMT2" RELATED [EC:2.1.1.149] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149] synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149] xref: EC:2.1.1.149 xref: KEGG_REACTION:R06816 xref: MetaCyc:RXN-8452 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0070449 name: elongin complex namespace: cellular_component def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits." [PMID:12676794] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "elongin (SIII) complex" EXACT [CORUM:56] synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0070450 name: interleukin4-interleukin-4 receptor complex namespace: cellular_component def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772] synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah] synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070451 name: cell hair namespace: cellular_component def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah] synonym: "non-sensory hair" EXACT [GOC:bf] xref: Wikipedia:Membrane_nanotube is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0070452 name: positive regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] synonym: "activation of ergosterol biosynthetic process" NARROW [] synonym: "positive regulation of ergosterol anabolism" EXACT [] synonym: "positive regulation of ergosterol biosynthesis" EXACT [] synonym: "positive regulation of ergosterol formation" EXACT [] synonym: "positive regulation of ergosterol synthesis" EXACT [] synonym: "stimulation of ergosterol biosynthetic process" NARROW [] synonym: "up regulation of ergosterol biosynthetic process" EXACT [] synonym: "up-regulation of ergosterol biosynthetic process" EXACT [] synonym: "upregulation of ergosterol biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032443 ! regulation of ergosterol biosynthetic process is_a: GO:0106120 ! positive regulation of sterol biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006696 ! ergosterol biosynthetic process relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0070453 name: regulation of heme biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] synonym: "regulation of haem biosynthesis" EXACT [GOC:mah] synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "regulation of heme anabolism" EXACT [GOC:mah] synonym: "regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "regulation of heme formation" EXACT [GOC:mah] synonym: "regulation of heme synthesis" EXACT [GOC:mah] is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006783 ! heme biosynthetic process relationship: regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070454 name: negative regulation of heme biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "negative regulation of heme anabolism" EXACT [GOC:mah] synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of heme formation" EXACT [GOC:mah] synonym: "negative regulation of heme synthesis" EXACT [GOC:mah] is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006783 ! heme biosynthetic process relationship: negatively_regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070455 name: positive regulation of heme biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] synonym: "activation of heme biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah] synonym: "positive regulation of heme anabolism" EXACT [GOC:mah] synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of heme formation" EXACT [GOC:mah] synonym: "positive regulation of heme synthesis" EXACT [GOC:mah] synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah] is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006783 ! heme biosynthetic process relationship: positively_regulates GO:0006783 ! heme biosynthetic process [Term] id: GO:0070456 name: galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah] is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0070457 name: D-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881] is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0070458 name: cellular detoxification of nitrogen compound namespace: biological_process def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah] synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah] is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1990748 ! cellular detoxification relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0070459 name: prolactin secretion namespace: biological_process def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070460 name: thyroid-stimulating hormone secretion namespace: biological_process def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah] synonym: "TSH secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0070461 name: SAGA-type complex namespace: cellular_component def: "A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012] synonym: "SAGA family complex" EXACT [PMID:17337012] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0070462 name: plus-end specific microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148] is_a: GO:0007019 ! microtubule depolymerization [Term] id: GO:0070463 name: tubulin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148] synonym: "tubulin-activated ATPase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0070464 name: alphav-beta3 integrin-collagen alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070465 name: alpha1-beta1 integrin-alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070466 name: alpha2-beta1 integrin-alpha3(VI) complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070467 name: RC-1 DNA recombination complex namespace: cellular_component def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910] synonym: "DNA recombination complex RC-1" EXACT [GOC:mah] synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070468 name: dentin secretion namespace: biological_process def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin." [GOC:mah, http://herkules.oulu.fi/isbn9514270355/html/i259726.html, PMID:12856968] synonym: "dentine secretion" EXACT [GOC:mah] synonym: "predentin secretion" EXACT [http://herkules.oulu.fi/isbn9514270355/html/i259726.html] is_a: GO:0070278 ! extracellular matrix constituent secretion relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth [Term] id: GO:0070469 name: respirasome namespace: cellular_component def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684, Wikipedia:Respirasome] comment: Changed label as requested\nhttps://github.com/geneontology/go-ontology/issues/12846 synonym: "membrane electron transport chain" EXACT [GOC:mah] synonym: "respiratory chain" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016020 ! membrane [Term] id: GO:0070470 name: plasma membrane respirasome namespace: cellular_component def: "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:imk, GOC:mah, ISBN:0198547684] comment: Changed label as requested\nhttps://github.com/geneontology/go-ontology/issues/12846 synonym: "plasma membrane electron transport chain" EXACT [GOC:mah] synonym: "plasma membrane respiratory chain" EXACT [] is_a: GO:0070469 ! respirasome relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0070471 name: uterine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl] synonym: "myometrial contraction" EXACT [GOC:sl] synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "myometrium contraction" EXACT [GOC:sl] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0070472 name: regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "regulation of myometrial contraction" EXACT [GOC:sl] synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "regulation of myometrium contraction" EXACT [GOC:sl] is_a: GO:0006940 ! regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070471 ! uterine smooth muscle contraction relationship: regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070473 name: negative regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl] synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl] synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:0070472 ! regulation of uterine smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070471 ! uterine smooth muscle contraction relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070474 name: positive regulation of uterine smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl] synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl] synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah] synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:0070472 ! regulation of uterine smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070471 ! uterine smooth muscle contraction relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction [Term] id: GO:0070475 name: rRNA base methylation namespace: biological_process def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0070476 name: rRNA (guanine-N7)-methylation namespace: biological_process def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah] is_a: GO:0036265 ! RNA (guanine-N7)-methylation is_a: GO:0070475 ! rRNA base methylation [Term] id: GO:0070477 name: endospore core namespace: cellular_component def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0070478 name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863] synonym: "3'-5' NMD" EXACT [GOC:jp] synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp] synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay is_a: GO:0034427 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [Term] id: GO:0070479 name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525] synonym: "5'-3' NMD" EXACT [GOC:jp] synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp] synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay is_a: GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' is_a: GO:0070480 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay [Term] id: GO:0070480 name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay." [GOC:jp] synonym: "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay" EXACT [GOC:mah] synonym: "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay" EXACT [GOC:mah] synonym: "exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay" EXACT [GOC:mah] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic intersection_of: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [Term] id: GO:0070481 name: nuclear-transcribed mRNA catabolic process, non-stop decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110] synonym: "non-stop decay" EXACT [GOC:jp] synonym: "non-stop mRNA decay" EXACT [GOC:jp] synonym: "nonstop mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah] synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0070483 name: detection of hypoxia namespace: biological_process def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] is_a: GO:0001666 ! response to hypoxia is_a: GO:0003032 ! detection of oxygen [Term] id: GO:0070484 name: dehydro-D-arabinono-1,4-lactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah] is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901334 ! lactone metabolic process [Term] id: GO:0070485 name: dehydro-D-arabinono-1,4-lactone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [CHEBI:17803, GOC:cjk, GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah] is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process is_a: GO:1901336 ! lactone biosynthetic process [Term] id: GO:0070486 name: leukocyte aggregation namespace: biological_process def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "immune cell aggregation" EXACT [CL:0000738] synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl] synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl] synonym: "white corpuscle aggregation" EXACT [GOC:sl] is_a: GO:0007159 ! leukocyte cell-cell adhesion [Term] id: GO:0070487 name: monocyte aggregation namespace: biological_process def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl] is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0070488 name: neutrophil aggregation namespace: biological_process def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah] synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah] is_a: GO:0070486 ! leukocyte aggregation [Term] id: GO:0070489 name: T cell aggregation namespace: biological_process def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508] synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl] synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah] synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah] is_a: GO:0071593 ! lymphocyte aggregation [Term] id: GO:0070490 name: protein pupylation namespace: biological_process def: "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670] synonym: "Pup-protein conjugation" EXACT [GOC:mah] synonym: "pupylation" EXACT [GOC:mah] is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0070491 name: repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah, GOC:txnOH] is_a: GO:0140297 ! DNA-binding transcription factor binding [Term] id: GO:0070492 name: oligosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah] is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0070493 name: thrombin-activated receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265] synonym: "thrombin receptor signaling pathway" EXACT [] synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0070494 name: regulation of thrombin-activated receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] synonym: "regulation of thrombin receptor signaling pathway" EXACT [] synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070493 ! thrombin-activated receptor signaling pathway relationship: regulates GO:0070493 ! thrombin-activated receptor signaling pathway [Term] id: GO:0070495 name: negative regulation of thrombin-activated receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] synonym: "negative regulation of thrombin receptor signaling pathway" EXACT [] synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway relationship: negatively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway [Term] id: GO:0070496 name: positive regulation of thrombin-activated receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] synonym: "positive regulation of thrombin receptor signaling pathway" EXACT [] synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway relationship: positively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway [Term] id: GO:0070497 name: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+." [GOC:imk, MetaCyc:RXN0-5507, PMID:19231875] xref: EC:4.1.2.50 xref: MetaCyc:RXN0-5507 xref: RHEA:27966 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0070498 name: interleukin-1-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add] synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add] synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah] synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add] synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add] synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0071347 ! cellular response to interleukin-1 [Term] id: GO:0070499 name: exosporium assembly namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah] synonym: "exosporium formation" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0045229 ! external encapsulating structure organization [Term] id: GO:0070500 name: poly-gamma-glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0070501 name: poly-gamma-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah] synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah] synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah] is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0070500 ! poly-gamma-glutamate metabolic process [Term] id: GO:0070502 name: capsule poly-gamma-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787] synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah] synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah] is_a: GO:0045230 ! capsule organization is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process [Term] id: GO:0070503 name: selenium-containing prosthetic group metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0051189 ! prosthetic group metabolic process [Term] id: GO:0070504 name: selenium-containing prosthetic group biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah] synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah] is_a: GO:0051191 ! prosthetic group biosynthetic process is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process [Term] id: GO:0070505 name: pollen coat namespace: cellular_component def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271] synonym: "pollenkitt" EXACT [PMID:15012271] synonym: "tryphine" EXACT [PMID:15012271] is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0070506 name: high-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis." [GOC:bf, GOC:BHF, GOC:rl, PMID:9211901] synonym: "HDL receptor" EXACT [GOC:rl] synonym: "high-density lipoprotein receptor activity" EXACT [GOC:dph] is_a: GO:0030228 ! lipoprotein particle receptor activity relationship: has_part GO:0008035 ! high-density lipoprotein particle binding [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000226 ! microtubule cytoskeleton organization relationship: regulates GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0070508 name: cholesterol import namespace: biological_process def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl] synonym: "cholesterol uptake" EXACT [GOC:rl] is_a: GO:0030301 ! cholesterol transport is_a: GO:0035376 ! sterol import [Term] id: GO:0070509 name: calcium ion import namespace: biological_process def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah] synonym: "calcium ion uptake" EXACT [GOC:mah] synonym: "transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0070510 name: regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034770 ! histone H4-K20 methylation relationship: regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070511 name: negative regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:0070510 ! regulation of histone H4-K20 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034770 ! histone H4-K20 methylation relationship: negatively_regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070512 name: positive regulation of histone H4-K20 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah] synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah] synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah] synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:0070510 ! regulation of histone H4-K20 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034770 ! histone H4-K20 methylation relationship: positively_regulates GO:0034770 ! histone H4-K20 methylation [Term] id: GO:0070513 name: death domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'. is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0070514 name: SRF-myogenin-E12 complex namespace: cellular_component def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0070515 name: alphaIIb-beta3 integrin-talin complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236] synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070516 name: CAK-ERCC2 complex namespace: cellular_component def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070517 name: DNA replication factor C core complex namespace: cellular_component def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326] synonym: "RFC core complex" EXACT [CORUM:278] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex [Term] id: GO:0070518 name: alpha4-beta1 integrin-CD53 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325] synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070519 name: alpha4-beta1 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325] synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070520 name: alpha4-beta1 integrin-CD81 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325] synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070521 name: alpha4-beta1 integrin-CD82 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070522 name: ERCC4-ERCC1 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "Rad1-Rad10 complex" EXACT [GOC:mah] synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0070523 name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [Term] id: GO:0070524 name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] xref: EC:1.1.1.146 xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [Term] id: GO:0070525 name: tRNA threonylcarbamoyladenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007] synonym: "t6A metabolic process" EXACT [PMID:19287007] synonym: "t6A metabolism" EXACT [PMID:19287007] synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0070527 name: platelet aggregation namespace: biological_process def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] synonym: "blood platelet aggregation" EXACT [CL:0000233] synonym: "thrombocyte aggregation" RELATED [CL:0000233] is_a: GO:0034109 ! homotypic cell-cell adhesion relationship: part_of GO:0030168 ! platelet activation [Term] id: GO:0070528 name: protein kinase C signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah] synonym: "PKC signal transduction" EXACT [GOC:signaling] synonym: "PKC signaling cascade" RELATED [GOC:mah] synonym: "protein kinase C signal transduction" EXACT [GOC:signaling] synonym: "protein kinase C signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase C signalling cascade" RELATED [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0070529 name: L-tryptophan aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070530 name: K63-linked polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341] is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding [Term] id: GO:0070531 name: BRCA1-A complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070532 name: BRCA1-B complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070533 name: BRCA1-C complex namespace: cellular_component def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070534 name: protein K63-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404] synonym: "protein K63-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination [Term] id: GO:0070535 name: histone H2A K63-linked ubiquitination namespace: biological_process def: "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235] is_a: GO:0033522 ! histone H2A ubiquitination is_a: GO:0070534 ! protein K63-linked ubiquitination [Term] id: GO:0070536 name: protein K63-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193] is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0070537 name: histone H2A K63-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193] is_a: GO:0016578 ! histone deubiquitination is_a: GO:0070536 ! protein K63-linked deubiquitination [Term] id: GO:0070538 name: oleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [CHEBI:16196, GOC:lp, GOC:mah] is_a: GO:0036041 ! long-chain fatty acid binding [Term] id: GO:0070539 name: linoleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [CHEBI:17351, GOC:lp, GOC:mah] is_a: GO:0036041 ! long-chain fatty acid binding [Term] id: GO:0070540 name: stearic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [CHEBI:28842, GOC:lp, GOC:mah] is_a: GO:0036041 ! long-chain fatty acid binding [Term] id: GO:0070541 name: response to platinum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl] synonym: "response to platinum" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0070542 name: response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [CHEBI:35366, GOC:lp] is_a: GO:0001101 ! response to acid chemical is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0070543 name: response to linoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [CHEBI:17351, GOC:lp] synonym: "response to linoleate" EXACT [GOC:mah] is_a: GO:0070542 ! response to fatty acid [Term] id: GO:0070544 name: histone H3-K36 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644] synonym: "H3K36 demethylation" RELATED [] is_a: GO:0070076 ! histone lysine demethylation [Term] id: GO:0070545 name: PeBoW complex namespace: cellular_component def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005730 ! nucleolus relationship: part_of GO:0030686 ! 90S preribosome [Term] id: GO:0070546 name: L-phenylalanine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070547 name: L-tyrosine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070548 name: L-glutamine aminotransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0070549 name: negative regulation of translation involved in RNA interference namespace: biological_process def: "A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA." [GOC:mah, PMID:18771919] synonym: "down regulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "down-regulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "downregulation of translation involved in RNA interference" EXACT [GOC:mah] synonym: "inhibition of translation involved in RNA interference" NARROW [GOC:mah] synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah] is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated intersection_of: GO:0017148 ! negative regulation of translation intersection_of: part_of GO:0016246 ! RNA interference relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0070550 name: rDNA condensation namespace: biological_process def: "The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:dgf, PMID:10811823, PMID:15137940] synonym: "rDNA packaging" EXACT [] is_a: GO:0006323 ! DNA packaging relationship: part_of GO:0030261 ! chromosome condensation [Term] id: GO:0070551 name: endoribonuclease activity, cleaving siRNA-paired mRNA namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377] synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0070552 name: BRISC complex namespace: cellular_component def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070553 name: nicotinic acid receptor activity namespace: molecular_function def: "Combining with nicotinic acid to initiate a change in cell activity." [CHEBI:15940, GOC:mah, PMID:12522134] synonym: "niacin receptor activity" EXACT [CHEBI:15940, GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0070554 name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex namespace: cellular_component def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312] synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842] synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842] is_a: GO:0031201 ! SNARE complex [Term] id: GO:0070555 name: response to interleukin-1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah] synonym: "response to IL-1" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine [Term] id: GO:0070556 name: TAF4B-containing transcription factor TFIID complex namespace: cellular_component def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156] synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485] is_a: GO:0005669 ! transcription factor TFIID complex [Term] id: GO:0070557 name: PCNA-p21 complex namespace: cellular_component def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0070558 name: alphaM-beta2 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662] synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0070559 name: lysosomal multienzyme complex namespace: cellular_component def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459] synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0070560 name: protein secretion by platelet namespace: biological_process def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah] is_a: GO:0009306 ! protein secretion is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002576 ! platelet degranulation created_by: midori creation_date: 2009-04-09T02:38:05Z [Term] id: GO:0070561 name: vitamin D receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589] synonym: "calcitriol signaling pathway" NARROW [GOC:bf] synonym: "VDR signaling pathway" EXACT [PMID:12637589] synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0030522 ! intracellular receptor signaling pathway relationship: part_of GO:0071305 ! cellular response to vitamin D created_by: midori creation_date: 2009-04-14T01:43:59Z [Term] id: GO:0070562 name: regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589] synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0032107 ! regulation of response to nutrient levels intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070561 ! vitamin D receptor signaling pathway relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway created_by: midori creation_date: 2009-04-14T01:46:03Z [Term] id: GO:0070563 name: negative regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah] synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah] synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway created_by: midori creation_date: 2009-04-14T01:59:21Z [Term] id: GO:0070564 name: positive regulation of vitamin D receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah] synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah] synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway created_by: midori creation_date: 2009-04-14T02:02:54Z [Term] id: GO:0070565 name: telomere-telomerase complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0032993 ! protein-DNA complex relationship: part_of GO:0000781 ! chromosome, telomeric region created_by: midori creation_date: 2009-04-14T03:07:50Z [Term] id: GO:0070566 name: adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah] is_a: GO:0016779 ! nucleotidyltransferase activity created_by: midori creation_date: 2009-04-15T11:04:22Z [Term] id: GO:0070567 name: cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah] is_a: GO:0016779 ! nucleotidyltransferase activity created_by: midori creation_date: 2009-04-15T11:05:22Z [Term] id: GO:0070568 name: guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah] is_a: GO:0016779 ! nucleotidyltransferase activity created_by: midori creation_date: 2009-04-15T11:05:47Z [Term] id: GO:0070569 name: uridylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah] synonym: "uridyl transferase activity" EXACT [] synonym: "uridyltransferase activity" EXACT [] is_a: GO:0016779 ! nucleotidyltransferase activity created_by: midori creation_date: 2009-04-15T11:06:07Z [Term] id: GO:0070570 name: regulation of neuron projection regeneration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031102 ! neuron projection regeneration relationship: regulates GO:0031102 ! neuron projection regeneration created_by: midori creation_date: 2009-04-15T01:23:48Z [Term] id: GO:0070571 name: negative regulation of neuron projection regeneration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] synonym: "growth cone collapse" RELATED [GOC:pr] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0070570 ! regulation of neuron projection regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031102 ! neuron projection regeneration relationship: negatively_regulates GO:0031102 ! neuron projection regeneration created_by: midori creation_date: 2009-04-15T01:43:19Z [Term] id: GO:0070572 name: positive regulation of neuron projection regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0070570 ! regulation of neuron projection regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031102 ! neuron projection regeneration relationship: positively_regulates GO:0031102 ! neuron projection regeneration created_by: midori creation_date: 2009-04-15T01:45:27Z [Term] id: GO:0070573 name: metallodipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb] synonym: "metalloexodipeptidase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-2022398 "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)" xref: Reactome:R-HSA-2022405 "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-2065355 "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" is_a: GO:0008235 ! metalloexopeptidase activity is_a: GO:0016805 ! dipeptidase activity created_by: midori creation_date: 2009-04-15T03:11:29Z [Term] id: GO:0070574 name: cadmium ion transmembrane transport namespace: biological_process def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "cadmium ion membrane transport" EXACT [] synonym: "transmembrane cadmium transport" EXACT [GOC:mah] is_a: GO:0015691 ! cadmium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: midori creation_date: 2009-04-20T03:31:47Z [Term] id: GO:0070575 name: peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation namespace: biological_process def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah] synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0007323 ! peptide pheromone maturation is_a: GO:0046999 ! regulation of conjugation relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation created_by: midori creation_date: 2009-04-20T04:32:07Z [Term] id: GO:0070576 name: vitamin D 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903] synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl] synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl] synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl] is_a: GO:0004497 ! monooxygenase activity created_by: midori creation_date: 2009-04-21T02:20:52Z [Term] id: GO:0070577 name: lysine-acetylated histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821] synonym: "acetylated histone residue binding" BROAD [GOC:rl] is_a: GO:0042393 ! histone binding is_a: GO:0140033 ! acetylation-dependent protein binding created_by: midori creation_date: 2009-04-21T03:03:35Z [Term] id: GO:0070578 name: RISC-loading complex namespace: cellular_component def: "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710] synonym: "microRNA loading complex" EXACT [GOC:ab] synonym: "miRLC" EXACT [GOC:ab] synonym: "RLC" RELATED [GOC:ab, GOC:mah] is_a: GO:1902555 ! endoribonuclease complex created_by: midori creation_date: 2009-04-22T01:40:19Z [Term] id: GO:0070579 name: methylcytosine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2." [PMID:19372391] xref: Reactome:R-HSA-5220952 "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine" xref: Reactome:R-HSA-5220990 "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine" xref: Reactome:R-HSA-5221014 "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine" is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity created_by: midori creation_date: 2009-04-22T02:29:41Z [Term] id: GO:0070580 name: base J metabolic process namespace: biological_process def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062] synonym: "base J metabolism" EXACT [GOC:mah] synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah] synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062] is_a: GO:0006304 ! DNA modification created_by: midori creation_date: 2009-04-22T02:37:23Z [Term] id: GO:0070581 name: rolling circle DNA replication namespace: biological_process def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732] synonym: "rolling circle replication" EXACT [GOC:cb] is_a: GO:0006261 ! DNA-dependent DNA replication created_by: midori creation_date: 2009-04-22T02:53:52Z [Term] id: GO:0070582 name: theta DNA replication namespace: biological_process def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732] synonym: "theta replication" EXACT [GOC:cb] is_a: GO:0006261 ! DNA-dependent DNA replication created_by: midori creation_date: 2009-04-22T02:54:50Z [Term] id: GO:0070583 name: spore membrane bending pathway namespace: biological_process def: "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:dgf, PMID:18756268] synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah] synonym: "forespore membrane bending" EXACT [GOC:mah] synonym: "FSM bending" EXACT [GOC:mah] is_a: GO:0061024 ! membrane organization is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0032120 ! ascospore-type prospore membrane assembly created_by: midori creation_date: 2009-04-24T10:48:09Z [Term] id: GO:0070584 name: mitochondrion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah] comment: This term was added by GO_REF:0000021. Note that this term is intended for annotation of gene products involved in mitochondrial shape changes associated with development; an example is the morphogenesis of the Nebenkern during spermatogenesis. is_a: GO:0007005 ! mitochondrion organization is_a: GO:0032990 ! cell part morphogenesis created_by: midori creation_date: 2009-04-24T10:54:19Z [Term] id: GO:0070585 name: protein localization to mitochondrion namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] synonym: "protein localization in mitochondrion" EXACT [] is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2009-04-24T02:31:18Z [Term] id: GO:0070586 name: cell-cell adhesion involved in gastrulation namespace: biological_process def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] comment: This term was added by GO_REF:0000021. is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0007369 ! gastrulation relationship: part_of GO:0007369 ! gastrulation created_by: midori creation_date: 2009-04-24T02:48:23Z [Term] id: GO:0070587 name: regulation of cell-cell adhesion involved in gastrulation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation created_by: midori creation_date: 2009-04-24T02:51:07Z [Term] id: GO:0070588 name: calcium ion transmembrane transport namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "calcium ion membrane transport" EXACT [] synonym: "transmembrane calcium transport" EXACT [GOC:mah] is_a: GO:0006816 ! calcium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: midori creation_date: 2009-04-28T10:44:09Z [Term] id: GO:0070589 name: cellular component macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah] synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah] is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0044085 ! cellular component biogenesis created_by: midori creation_date: 2009-04-28T11:01:25Z [Term] id: GO:0070590 name: spore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore created_by: midori creation_date: 2009-04-28T01:06:10Z [Term] id: GO:0070591 name: ascospore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah] is_a: GO:0009272 ! fungal-type cell wall biogenesis is_a: GO:0070590 ! spore wall biogenesis is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030437 ! ascospore formation created_by: midori creation_date: 2009-04-28T01:12:11Z [Term] id: GO:0070592 name: cell wall polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah] synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah] synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah] synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process created_by: midori creation_date: 2009-04-28T01:25:54Z [Term] id: GO:0070593 name: dendrite self-avoidance namespace: biological_process def: "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] synonym: "dendrite repulsion" EXACT [GOC:sart] is_a: GO:0008038 ! neuron recognition created_by: midori creation_date: 2009-04-28T03:29:14Z [Term] id: GO:0070594 name: juvenile hormone response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "JHRE binding" EXACT [GOC:mah] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: midori creation_date: 2009-04-28T03:31:27Z [Term] id: GO:0070595 name: (1->3)-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "1,3-alpha-glucan metabolic process" EXACT [GOC:mah] synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0030978 ! alpha-glucan metabolic process created_by: midori creation_date: 2009-04-28T03:35:03Z [Term] id: GO:0070596 name: (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah] synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah] synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah] is_a: GO:0030979 ! alpha-glucan biosynthetic process is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-28T03:39:24Z [Term] id: GO:0070597 name: cell wall (1->3)-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-28T04:03:00Z [Term] id: GO:0070598 name: cell wall (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process is_a: GO:0070596 ! (1->3)-alpha-glucan biosynthetic process is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-28T04:04:59Z [Term] id: GO:0070599 name: fungal-type cell wall (1->3)-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "ascospore wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process created_by: midori creation_date: 2009-04-28T04:07:23Z [Term] id: GO:0070600 name: fungal-type cell wall (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process is_a: GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process is_a: GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-28T04:09:48Z [Term] id: GO:0070601 name: centromeric sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah] synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah] is_a: GO:0007062 ! sister chromatid cohesion created_by: midori creation_date: 2009-04-28T04:31:00Z [Term] id: GO:0070602 name: regulation of centromeric sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah] synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah] is_a: GO:0007063 ! regulation of sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070601 ! centromeric sister chromatid cohesion relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion created_by: midori creation_date: 2009-04-28T04:32:53Z [Term] id: GO:0070603 name: SWI/SNF superfamily-type complex namespace: cellular_component alt_id: GO:0090544 def: "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] subset: gocheck_do_not_manually_annotate synonym: "BAF-type complex" EXACT [] synonym: "SWI-SNF global transcription activator complex" RELATED [CORUM:224] synonym: "SWI-SNF-type complex" EXACT [GOC:mah] synonym: "SWI/SNF-type complex" RELATED [GOC:krc] synonym: "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex" RELATED [GOC:krc] is_a: GO:1904949 ! ATPase complex relationship: part_of GO:0000790 ! nuclear chromatin created_by: midori creation_date: 2009-04-29T12:55:46Z [Term] id: GO:0070605 name: regulation of (1->3)-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "regulation of 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0032948 ! regulation of alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process relationship: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-29T01:20:12Z [Term] id: GO:0070606 name: regulation of (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah] synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah] is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process relationship: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process created_by: midori creation_date: 2009-04-29T01:22:45Z [Term] id: GO:0070607 name: regulation of cell wall (1->3)-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process relationship: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-29T01:24:57Z [Term] id: GO:0070608 name: regulation of cell wall (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0070606 ! regulation of (1->3)-alpha-glucan biosynthetic process is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process relationship: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process created_by: midori creation_date: 2009-04-29T01:27:15Z [Term] id: GO:0070609 name: regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process relationship: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process created_by: midori creation_date: 2009-04-29T01:29:02Z [Term] id: GO:0070610 name: regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis is_a: GO:0070608 ! regulation of cell wall (1->3)-alpha-glucan biosynthetic process is_a: GO:0070609 ! regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process relationship: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process created_by: midori creation_date: 2009-04-29T01:32:19Z [Term] id: GO:0070611 name: histone methyltransferase activity (H3-R2 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [GOC:mah, PMID:17898714] synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity relationship: part_of GO:0034970 ! histone H3-R2 methylation created_by: midori creation_date: 2009-04-29T02:04:44Z [Term] id: GO:0070612 name: histone methyltransferase activity (H2A-R3 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A." [GOC:mah, PMID:17898714] synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah] synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah] is_a: GO:0008469 ! histone-arginine N-methyltransferase activity created_by: midori creation_date: 2009-04-29T02:06:45Z [Term] id: GO:0070613 name: regulation of protein processing namespace: biological_process alt_id: GO:0010953 def: "Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of protein maturation by peptide bond cleavage" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016485 ! protein processing relationship: regulates GO:0016485 ! protein processing created_by: midori creation_date: 2009-04-29T02:49:14Z [Term] id: GO:0070614 name: tungstate ion transport namespace: biological_process def: "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh] is_a: GO:0015698 ! inorganic anion transport created_by: midori creation_date: 2009-04-29T03:07:40Z [Term] id: GO:0070615 name: nucleosome-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes." [GOC:mah, PMID:19165147] synonym: "nucleosome-activated ATPase activity" EXACT [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled created_by: midori creation_date: 2009-04-29T03:15:31Z [Term] id: GO:0070616 name: regulation of thiamine diphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] synonym: "regulation of thiamin diphosphate biosynthetic process" EXACT [] synonym: "regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate formation" EXACT [GOC:mah] synonym: "regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009229 ! thiamine diphosphate biosynthetic process relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process created_by: midori creation_date: 2009-04-29T03:37:35Z [Term] id: GO:0070617 name: negative regulation of thiamine diphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] synonym: "down regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of thiamine diphosphate biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of thiamin diphosphate biosynthetic process" EXACT [] synonym: "negative regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate formation" EXACT [GOC:mah] synonym: "negative regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process relationship: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process created_by: midori creation_date: 2009-04-29T03:39:48Z [Term] id: GO:0070618 name: Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-04-29T04:19:02Z [Term] id: GO:0070619 name: Shc-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013] synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-04-29T04:30:00Z [Term] id: GO:0070620 name: EGFR-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-04-29T04:36:30Z [Term] id: GO:0070621 name: EGFR-Shc-Grb2-Sos complex namespace: cellular_component def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-04-29T04:38:10Z [Term] id: GO:0070622 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex namespace: cellular_component def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155] synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406] synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups relationship: part_of GO:0005764 ! lysosome created_by: midori creation_date: 2009-04-29T04:50:35Z [Term] id: GO:0070623 name: regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] synonym: "regulation of thiamin biosynthetic process" EXACT [] synonym: "regulation of thiamine anabolism" EXACT [GOC:mah] synonym: "regulation of thiamine biosynthesis" EXACT [GOC:mah] synonym: "regulation of thiamine formation" EXACT [GOC:mah] synonym: "regulation of thiamine synthesis" EXACT [GOC:mah] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009228 ! thiamine biosynthetic process relationship: regulates GO:0009228 ! thiamine biosynthetic process created_by: midori creation_date: 2009-05-01T03:15:49Z [Term] id: GO:0070624 name: negative regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] synonym: "down regulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of thiamine biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of thiamine biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of thiamin biosynthetic process" EXACT [] synonym: "negative regulation of thiamine anabolism" EXACT [GOC:mah] synonym: "negative regulation of thiamine biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of thiamine formation" EXACT [GOC:mah] synonym: "negative regulation of thiamine synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0070623 ! regulation of thiamine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009228 ! thiamine biosynthetic process relationship: negatively_regulates GO:0009228 ! thiamine biosynthetic process created_by: midori creation_date: 2009-05-01T03:20:41Z [Term] id: GO:0070625 name: zymogen granule exocytosis namespace: biological_process def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889] is_a: GO:0017156 ! calcium-ion regulated exocytosis created_by: midori creation_date: 2009-05-01T03:56:02Z [Term] id: GO:0070626 name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG_REACTION:R04559 xref: MetaCyc:AICARSYN-RXN is_a: GO:0016842 ! amidine-lyase activity created_by: midori creation_date: 2009-05-01T04:13:49Z [Term] id: GO:0070628 name: proteasome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] subset: goslim_chembl is_a: GO:0044877 ! protein-containing complex binding created_by: midori creation_date: 2009-05-01T04:38:58Z [Term] id: GO:0070629 name: (1->4)-alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "(1->4)-alpha-D-glucan metabolism" EXACT [GOC:mah] synonym: "1,4-alpha-D-glucan metabolism" EXACT [GOC:mah] synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah] synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah] synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah] is_a: GO:0030978 ! alpha-glucan metabolic process created_by: midori creation_date: 2009-05-01T04:45:42Z [Term] id: GO:0070630 name: (1->4)-alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah] synonym: "(1->4)-alpha-D-glucan anabolism" EXACT [GOC:mah] synonym: "(1->4)-alpha-D-glucan biosynthesis" EXACT [GOC:mah] synonym: "(1->4)-alpha-D-glucan formation" EXACT [GOC:mah] synonym: "(1->4)-alpha-D-glucan synthesis" EXACT [GOC:mah] synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah] synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah] synonym: "1,4-alpha-glucan biosynthetic process" EXACT [GOC:mah] synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah] synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah] synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah] synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah] synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah] synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah] synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah] is_a: GO:0030979 ! alpha-glucan biosynthetic process is_a: GO:0070629 ! (1->4)-alpha-glucan metabolic process created_by: midori creation_date: 2009-05-01T04:46:34Z [Term] id: GO:0070631 name: spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah] synonym: "spindle pole body localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization is_a: GO:0061842 ! microtubule organizing center localization created_by: midori creation_date: 2009-05-06T02:21:38Z [Term] id: GO:0070632 name: establishment of spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment of spindle pole body localisation" EXACT [GOC:mah] synonym: "spindle pole body positioning" EXACT [GOC:vw] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0070631 ! spindle pole body localization created_by: midori creation_date: 2009-05-06T02:35:32Z [Term] id: GO:0070633 name: transepithelial transport namespace: biological_process def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] is_a: GO:0006810 ! transport created_by: midori creation_date: 2009-05-06T03:31:02Z [Term] id: GO:0070634 name: transepithelial ammonium transport namespace: biological_process def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] is_a: GO:0015696 ! ammonium transport is_a: GO:0070633 ! transepithelial transport created_by: midori creation_date: 2009-05-06T03:34:43Z [Term] id: GO:0070635 name: nicotinamide riboside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417] synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [CHEBI:15927] synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [CHEBI:15927] xref: MetaCyc:RXN-8441 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: midori creation_date: 2009-05-07T02:01:42Z [Term] id: GO:0070636 name: nicotinic acid riboside hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417] synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah] synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [CHEBI:27748] synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah] synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah] synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: midori creation_date: 2009-05-07T02:12:00Z [Term] id: GO:0070637 name: pyridine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: midori creation_date: 2009-05-07T02:24:21Z [Term] id: GO:0070638 name: pyridine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah] synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah] synonym: "pyridine nucleoside degradation" EXACT [GOC:mah] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0070637 ! pyridine nucleoside metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process created_by: midori creation_date: 2009-05-07T02:27:14Z [Term] id: GO:0070639 name: vitamin D2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [CHEBI:28934, GOC:BHF, GOC:mah] synonym: "calciferol metabolic process" EXACT [CHEBI:28934] synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934] synonym: "vitamin D2 metabolism" EXACT [GOC:mah] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042359 ! vitamin D metabolic process created_by: midori creation_date: 2009-05-08T02:11:35Z [Term] id: GO:0070640 name: vitamin D3 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [CHEBI:28940, GOC:BHF, GOC:mah] synonym: "calciol metabolic process" EXACT [CHEBI:28940] synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940] synonym: "vitamin D3 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: midori creation_date: 2009-05-08T02:24:24Z [Term] id: GO:0070641 name: vitamin D4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [CHEBI:33237, GOC:BHF, GOC:mah] synonym: "vitamin D4 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process created_by: midori creation_date: 2009-05-08T02:33:01Z [Term] id: GO:0070642 name: vitamin D5 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700] synonym: "vitamin D5 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process created_by: midori creation_date: 2009-05-08T02:47:41Z [Term] id: GO:0070643 name: vitamin D 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah] synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah] synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah] is_a: GO:0004497 ! monooxygenase activity created_by: midori creation_date: 2009-05-08T03:42:29Z [Term] id: GO:0070644 name: vitamin D response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: midori creation_date: 2009-05-08T04:23:44Z [Term] id: GO:0070645 name: Ubisch body namespace: cellular_component def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248] synonym: "orbicule" EXACT [PMID:14612572] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031012 ! extracellular matrix created_by: midori creation_date: 2009-05-11T11:35:33Z [Term] id: GO:0070646 name: protein modification by small protein removal namespace: biological_process def: "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah] is_a: GO:0006508 ! proteolysis is_a: GO:0070647 ! protein modification by small protein conjugation or removal created_by: midori creation_date: 2009-05-11T01:58:15Z [Term] id: GO:0070647 name: protein modification by small protein conjugation or removal namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] subset: goslim_drosophila subset: goslim_pombe subset: goslim_yeast is_a: GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2009-05-11T02:54:03Z [Term] id: GO:0070648 name: formin-nucleated actin cable namespace: cellular_component def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963] is_a: GO:0097518 ! parallel actin filament bundle created_by: midori creation_date: 2009-05-12T02:09:57Z [Term] id: GO:0070649 name: formin-nucleated actin cable assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963] synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah] is_a: GO:0030046 ! parallel actin filament bundle assembly is_a: GO:0110009 ! formin-nucleated actin cable organization created_by: midori creation_date: 2009-05-12T02:14:36Z [Term] id: GO:0070650 name: actin filament bundle distribution namespace: biological_process def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah] is_a: GO:0061572 ! actin filament bundle organization created_by: midori creation_date: 2009-05-12T02:20:58Z [Term] id: GO:0070651 name: nonfunctional rRNA decay namespace: biological_process def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089] synonym: "NRD" RELATED [GOC:rn] is_a: GO:0016075 ! rRNA catabolic process created_by: midori creation_date: 2009-05-28T02:22:49Z [Term] id: GO:0070652 name: HAUS complex namespace: cellular_component def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217] synonym: "HAUS augmin complex" EXACT [GOC:mm2] is_a: GO:0005875 ! microtubule associated complex created_by: midori creation_date: 2009-05-28T03:21:01Z [Term] id: GO:0070653 name: high-density lipoprotein particle receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a high-density lipoprotein receptor." [GOC:BHF, GOC:mah] synonym: "HDL receptor binding" EXACT [GOC:mah] synonym: "high-density lipoprotein receptor binding" EXACT [GOC:dph] is_a: GO:0070325 ! lipoprotein particle receptor binding created_by: midori creation_date: 2009-05-28T03:44:33Z [Term] id: GO:0070654 name: sensory epithelium regeneration namespace: biological_process def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250] is_a: GO:1990399 ! epithelium regeneration created_by: midori creation_date: 2009-05-28T04:02:27Z [Term] id: GO:0070655 name: mechanosensory epithelium regeneration namespace: biological_process def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250] is_a: GO:0070654 ! sensory epithelium regeneration created_by: midori creation_date: 2009-05-28T04:05:18Z [Term] id: GO:0070656 name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration namespace: biological_process def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0042490 ! mechanoreceptor differentiation intersection_of: GO:0042490 ! mechanoreceptor differentiation intersection_of: part_of GO:0070655 ! mechanosensory epithelium regeneration relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration created_by: midori creation_date: 2009-05-28T04:08:13Z [Term] id: GO:0070657 name: neuromast regeneration namespace: biological_process def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250] is_a: GO:0070655 ! mechanosensory epithelium regeneration created_by: midori creation_date: 2009-05-28T04:11:44Z [Term] id: GO:0070658 name: neuromast hair cell differentiation involved in neuromast regeneration namespace: biological_process def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0048886 ! neuromast hair cell differentiation is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration intersection_of: GO:0048886 ! neuromast hair cell differentiation intersection_of: part_of GO:0070657 ! neuromast regeneration relationship: part_of GO:0070657 ! neuromast regeneration created_by: midori creation_date: 2009-05-28T04:16:27Z [Term] id: GO:0070659 name: inner ear sensory epithelium regeneration namespace: biological_process def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250] is_a: GO:0070655 ! mechanosensory epithelium regeneration created_by: midori creation_date: 2009-05-28T04:21:09Z [Term] id: GO:0070660 name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration namespace: biological_process def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] is_a: GO:0060113 ! inner ear receptor cell differentiation is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration intersection_of: GO:0060113 ! inner ear receptor cell differentiation intersection_of: part_of GO:0070659 ! inner ear sensory epithelium regeneration relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration created_by: midori creation_date: 2009-05-28T04:24:23Z [Term] id: GO:0070661 name: leukocyte proliferation namespace: biological_process def: "The expansion of a leukocyte population by cell division." [GOC:add] is_a: GO:0008283 ! cell population proliferation created_by: midori creation_date: 2009-05-28T05:25:28Z [Term] id: GO:0070662 name: mast cell proliferation namespace: biological_process def: "The expansion of a mast cell population by cell division." [GOC:add] is_a: GO:0070661 ! leukocyte proliferation created_by: midori creation_date: 2009-05-28T05:27:51Z [Term] id: GO:0070663 name: regulation of leukocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070661 ! leukocyte proliferation relationship: regulates GO:0070661 ! leukocyte proliferation created_by: midori creation_date: 2009-05-28T05:30:39Z [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070661 ! leukocyte proliferation relationship: negatively_regulates GO:0070661 ! leukocyte proliferation created_by: midori creation_date: 2009-05-28T05:34:50Z [Term] id: GO:0070665 name: positive regulation of leukocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070661 ! leukocyte proliferation relationship: positively_regulates GO:0070661 ! leukocyte proliferation created_by: midori creation_date: 2009-05-28T05:36:46Z [Term] id: GO:0070666 name: regulation of mast cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070662 ! mast cell proliferation relationship: regulates GO:0070662 ! mast cell proliferation created_by: midori creation_date: 2009-05-28T05:40:43Z [Term] id: GO:0070667 name: negative regulation of mast cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah] synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070662 ! mast cell proliferation relationship: negatively_regulates GO:0070662 ! mast cell proliferation created_by: midori creation_date: 2009-05-28T05:45:11Z [Term] id: GO:0070668 name: positive regulation of mast cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] synonym: "activation of mast cell proliferation" NARROW [GOC:mah] synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah] synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah] synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0070666 ! regulation of mast cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070662 ! mast cell proliferation relationship: positively_regulates GO:0070662 ! mast cell proliferation created_by: midori creation_date: 2009-05-28T05:48:30Z [Term] id: GO:0070669 name: response to interleukin-2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] synonym: "response to IL-2" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-05-29T09:59:43Z [Term] id: GO:0070670 name: response to interleukin-4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] synonym: "response to IL-4" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-05-29T10:01:46Z [Term] id: GO:0070671 name: response to interleukin-12 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] synonym: "response to IL-12" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-05-29T10:02:31Z [Term] id: GO:0070672 name: response to interleukin-15 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] synonym: "response to IL-15" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-05-29T10:03:09Z [Term] id: GO:0070673 name: response to interleukin-18 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] synonym: "response to IL-18" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-05-29T10:03:52Z [Term] id: GO:0070674 name: hypoxanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde] synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "hypoxanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "hypoxanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "NAD-hypoxanthine dehydrogenase activity" EXACT [EC:1.17.1.4] is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor created_by: midori creation_date: 2009-05-29T01:02:13Z [Term] id: GO:0070675 name: hypoxanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde] synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "hypoxanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor created_by: midori creation_date: 2009-05-29T01:12:55Z [Term] id: GO:0070676 name: intralumenal vesicle formation namespace: biological_process def: "The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome." [GOC:jp, PMID:19234443] synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah] is_a: GO:0006900 ! vesicle budding from membrane is_a: GO:0007032 ! endosome organization relationship: occurs_in GO:0010008 ! endosome membrane created_by: midori creation_date: 2009-05-29T02:02:30Z [Term] id: GO:0070677 name: rRNA (cytosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805] is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity created_by: midori creation_date: 2009-05-29T03:37:53Z [Term] id: GO:0070678 name: preprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940] synonym: "unprocessed protein binding" EXACT [GOC:imk] is_a: GO:0005515 ! protein binding created_by: midori creation_date: 2009-05-29T03:41:54Z [Term] id: GO:0070679 name: inositol 1,4,5 trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah] synonym: "InsP3 binding" EXACT [GOC:mah] synonym: "IP3 binding" EXACT [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding created_by: midori creation_date: 2009-05-29T04:07:00Z [Term] id: GO:0070680 name: asparaginyl-tRNAAsn biosynthesis via transamidation namespace: biological_process def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4] xref: MetaCyc:PWY490-4 is_a: GO:0043039 ! tRNA aminoacylation created_by: midori creation_date: 2009-06-02T03:11:19Z [Term] id: GO:0070681 name: glutaminyl-tRNAGln biosynthesis via transamidation namespace: biological_process def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] xref: MetaCyc:PWY-5921 is_a: GO:0043039 ! tRNA aminoacylation created_by: midori creation_date: 2009-06-02T03:15:57Z [Term] id: GO:0070682 name: proteasome regulatory particle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159] synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah] is_a: GO:0043248 ! proteasome assembly created_by: midori creation_date: 2009-06-02T03:46:29Z [Term] id: GO:0070684 name: seminal clot liquefaction namespace: biological_process def: "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984] synonym: "semen liquefaction" EXACT [PMID:18482984] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007320 ! insemination created_by: midori creation_date: 2009-06-02T04:33:54Z [Term] id: GO:0070685 name: macropinocytic cup namespace: cellular_component def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041] synonym: "crown" EXACT [GOC:pf, PMID:9044041] is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: midori creation_date: 2009-06-03T10:18:00Z [Term] id: GO:0070686 name: macropinocytic cup membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah] synonym: "crown membrane" EXACT [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0070685 ! macropinocytic cup created_by: midori creation_date: 2009-06-03T10:52:25Z [Term] id: GO:0070687 name: macropinocytic cup cytoskeleton namespace: cellular_component def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah] synonym: "crown cytoskeleton" EXACT [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030864 ! cortical actin cytoskeleton relationship: part_of GO:0070685 ! macropinocytic cup created_by: midori creation_date: 2009-06-03T10:59:50Z [Term] id: GO:0070688 name: obsolete MLL5-L complex namespace: cellular_component def: "OBSOLETE. A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461] comment: This term was made obsolete because there is no evidence for the existence of this complex. is_obsolete: true created_by: midori creation_date: 2009-06-03T11:50:18Z [Term] id: GO:0070689 name: L-threonine catabolic process to propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:bf, GOC:mah, MetaCyc:PWY-5437] synonym: "L-threonine breakdown to propionate" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to propionate" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to propionate" EXACT [GOC:bf, GOC:mah] synonym: "threonine catabolic process to propionate" BROAD [GOC:bf] xref: MetaCyc:PWY-5437 is_a: GO:0006567 ! threonine catabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0042737 ! drug catabolic process created_by: midori creation_date: 2009-06-03T01:36:54Z [Term] id: GO:0070690 name: L-threonine catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA." [GOC:bf, GOC:mah, MetaCyc:PWY-5436] synonym: "L-threonine breakdown to acetyl-CoA" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to acetyl-CoA" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to acetyl-CoA" EXACT [GOC:bf, GOC:mah] synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf] xref: MetaCyc:PWY-5436 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0006567 ! threonine catabolic process is_a: GO:0042737 ! drug catabolic process created_by: midori creation_date: 2009-06-03T01:40:22Z [Term] id: GO:0070691 name: P-TEFb complex namespace: cellular_component def: "A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T." [GOC:mah, GOC:vw, http://en.wikipedia.org/wiki/P-TEFb, PMID:16721054, PMID:19328067] synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067] synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex" NARROW [GOC:vw] synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex" NARROW [GOC:bhm] synonym: "dimeric positive transcription elongation factor complex b" RELATED [] synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah] is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex created_by: midori creation_date: 2009-06-03T03:12:56Z [Term] id: GO:0070692 name: CTDK-1 complex namespace: cellular_component def: "A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638)." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067] synonym: "C-terminal domain kinase I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067] synonym: "CTDK-I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067] synonym: "Ctk complex" EXACT [PMID:16721054] synonym: "trimeric positive transcription elongation factor complex b" RELATED [] is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex created_by: midori creation_date: 2009-06-03T03:18:04Z [Term] id: GO:0070693 name: P-TEFb-cap methyltransferase complex namespace: cellular_component def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067] synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw] synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2009-06-04T02:38:58Z [Term] id: GO:0070694 name: deoxyribonucleoside 5'-monophosphate N-glycosidase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634] synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" EXACT [] xref: EC:3.2.2 xref: IMG:03312 xref: Reactome:R-HSA-8953339 "DNPH1 hydrolyses dGMP" is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: midori creation_date: 2009-06-04T03:06:57Z [Term] id: GO:0070695 name: FHF complex namespace: cellular_component def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-06-04T03:17:29Z [Term] id: GO:0070696 name: transmembrane receptor protein serine/threonine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] is_a: GO:0033612 ! receptor serine/threonine kinase binding created_by: midori creation_date: 2009-06-04T03:57:42Z [Term] id: GO:0070697 name: activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding created_by: midori creation_date: 2009-06-04T04:02:13Z [Term] id: GO:0070698 name: type I activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type I activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070697 ! activin receptor binding created_by: midori creation_date: 2009-06-04T04:15:21Z [Term] id: GO:0070699 name: type II activin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II activin receptor." [GOC:BHF, GOC:vk] is_a: GO:0070697 ! activin receptor binding created_by: midori creation_date: 2009-06-04T04:16:26Z [Term] id: GO:0070700 name: BMP receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a BMP receptor." [GOC:BHF, GOC:vk] synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah] is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding created_by: midori creation_date: 2009-06-04T04:24:16Z [Term] id: GO:0070701 name: mucus layer namespace: cellular_component def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, http://en.wikipedia.org/wiki/Mucin, PMID:18806221, PMID:19432394] synonym: "extracellular proteinaceous gel" BROAD [] synonym: "mucous" EXACT [] synonym: "mucous layer" EXACT [] synonym: "mucus" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region created_by: midori creation_date: 2009-06-08T02:31:34Z [Term] id: GO:0070702 name: inner mucus layer namespace: cellular_component def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] is_a: GO:0070701 ! mucus layer created_by: midori creation_date: 2009-06-08T02:38:55Z [Term] id: GO:0070703 name: outer mucus layer namespace: cellular_component def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] is_a: GO:0070701 ! mucus layer created_by: midori creation_date: 2009-06-08T02:44:51Z [Term] id: GO:0070704 name: sterol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: midori creation_date: 2009-06-08T03:53:44Z [Term] id: GO:0070705 name: RNA nucleotide insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah] is_a: GO:0009451 ! RNA modification created_by: midori creation_date: 2009-06-08T04:48:35Z [Term] id: GO:0070706 name: RNA nucleotide deletion namespace: biological_process def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah] synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah] is_a: GO:0009451 ! RNA modification created_by: midori creation_date: 2009-06-08T04:50:51Z [Term] id: GO:0070707 name: RNA dinucleotide insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion created_by: midori creation_date: 2009-06-08T04:50:59Z [Term] id: GO:0070708 name: RNA cytidine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA C insertion" EXACT [GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion created_by: midori creation_date: 2009-06-08T04:52:49Z [Term] id: GO:0070709 name: RNA guanosine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA G insertion" EXACT [GOC:mah] is_a: GO:0070705 ! RNA nucleotide insertion created_by: midori creation_date: 2009-06-08T04:57:26Z [Term] id: GO:0070710 name: RNA uridine deletion namespace: biological_process def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah] synonym: "RNA U deletion" EXACT [GOC:mah] synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah] is_a: GO:0070706 ! RNA nucleotide deletion created_by: midori creation_date: 2009-06-08T05:12:43Z [Term] id: GO:0070711 name: RNA adenosine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA AU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion created_by: midori creation_date: 2009-06-08T05:16:39Z [Term] id: GO:0070712 name: RNA cytidine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA CU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion created_by: midori creation_date: 2009-06-08T05:27:01Z [Term] id: GO:0070713 name: RNA guanosine-cytidine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA GC insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion created_by: midori creation_date: 2009-06-08T05:31:43Z [Term] id: GO:0070714 name: RNA guanosine-uridine insertion namespace: biological_process def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah] synonym: "RNA GU insertion" EXACT [GOC:mah] is_a: GO:0070707 ! RNA dinucleotide insertion created_by: midori creation_date: 2009-06-08T05:33:20Z [Term] id: GO:0070715 name: sodium-dependent organic cation transport namespace: biological_process def: "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0015695 ! organic cation transport created_by: midori creation_date: 2009-06-09T03:26:27Z [Term] id: GO:0070716 name: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication namespace: biological_process def: "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication." [GOC:BHF, GOC:mah] synonym: "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] is_a: GO:0006298 ! mismatch repair intersection_of: GO:0006298 ! mismatch repair intersection_of: part_of GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity relationship: part_of GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity created_by: midori creation_date: 2009-06-09T04:00:29Z [Term] id: GO:0070717 name: poly-purine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] is_a: GO:0003727 ! single-stranded RNA binding created_by: midori creation_date: 2009-06-10T03:32:15Z [Term] id: GO:0070718 name: alphaPDGFR-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-10T05:00:43Z [Term] id: GO:0070719 name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-10T05:04:20Z [Term] id: GO:0070720 name: Grb2-SHP-2 complex namespace: cellular_component def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-10T05:08:21Z [Term] id: GO:0070721 name: ISGF3 complex namespace: cellular_component def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351] synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-06-10T05:22:05Z [Term] id: GO:0070722 name: Tle3-Aes complex namespace: cellular_component def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148] synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex created_by: midori creation_date: 2009-06-10T05:45:28Z [Term] id: GO:0070723 name: response to cholesterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk] is_a: GO:0036314 ! response to sterol is_a: GO:0097305 ! response to alcohol created_by: midori creation_date: 2009-06-15T02:28:27Z [Term] id: GO:0070724 name: BMP receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468] synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: midori creation_date: 2009-06-15T02:34:27Z [Term] id: GO:0070725 name: Yb body namespace: cellular_component def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-06-15T05:17:28Z [Term] id: GO:0070726 name: cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0071555 ! cell wall organization relationship: part_of GO:0042546 ! cell wall biogenesis created_by: midori creation_date: 2009-06-16T03:58:20Z [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: midori creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070728 name: leucine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid." [CHEBI:25017, GOC:BHF, GOC:mah] synonym: "Leu binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding created_by: midori creation_date: 2009-06-17T03:16:30Z [Term] id: GO:0070729 name: cyclic nucleotide transport namespace: biological_process def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732] is_a: GO:0006862 ! nucleotide transport created_by: midori creation_date: 2009-06-17T03:49:56Z [Term] id: GO:0070730 name: cAMP transport namespace: biological_process def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732] synonym: "cyclic AMP transport" EXACT [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:0070729 ! cyclic nucleotide transport created_by: midori creation_date: 2009-06-17T03:53:45Z [Term] id: GO:0070731 name: cGMP transport namespace: biological_process def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732] synonym: "cyclic GMP transport" EXACT [GOC:mah] is_a: GO:0001408 ! guanine nucleotide transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0070729 ! cyclic nucleotide transport created_by: midori creation_date: 2009-06-17T04:40:27Z [Term] id: GO:0070732 name: spindle envelope namespace: cellular_component def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] subset: goslim_candida is_a: GO:0031967 ! organelle envelope created_by: midori creation_date: 2009-06-18T12:00:59Z [Term] id: GO:0070733 name: protein adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins." [GOC:mah, PMID:19039103, PMID:19362538] synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah] synonym: "AMPylator" RELATED [GOC:mah] xref: EC:2.7.7.n1 is_a: GO:0070566 ! adenylyltransferase activity relationship: part_of GO:0018117 ! protein adenylylation created_by: midori creation_date: 2009-06-18T01:09:15Z [Term] id: GO:0070734 name: histone H3-K27 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone." [GOC:mah, GOC:pr] synonym: "histone H3 K27 methylation" EXACT [GOC:mah] synonym: "histone H3K27me" EXACT [GOC:mah] synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah] is_a: GO:0034968 ! histone lysine methylation created_by: midori creation_date: 2009-06-19T11:44:37Z [Term] id: GO:0070735 name: protein-glycine ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-8867370 "TTLL3, TTLL8, TTLL10 polyglycylate tubulin" is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: midori creation_date: 2009-06-19T01:51:21Z [Term] id: GO:0070736 name: protein-glycine ligase activity, initiating namespace: molecular_function def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity, initiating" EXACT [GOC:mah] is_a: GO:0070735 ! protein-glycine ligase activity created_by: midori creation_date: 2009-06-19T01:56:32Z [Term] id: GO:0070737 name: protein-glycine ligase activity, elongating namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510] synonym: "protein glycylase activity, elongating" EXACT [GOC:mah] is_a: GO:0070735 ! protein-glycine ligase activity created_by: midori creation_date: 2009-06-19T02:00:21Z [Term] id: GO:0070738 name: tubulin-glycine ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510] synonym: "tubulin glycylase activity" EXACT [GOC:mah] is_a: GO:0070735 ! protein-glycine ligase activity created_by: midori creation_date: 2009-06-19T02:02:01Z [Term] id: GO:0070739 name: protein-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510] synonym: "protein glutamylase activity" EXACT [GOC:mah] synonym: "protein-glutamate ligase activity" EXACT [GOC:mah] is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: midori creation_date: 2009-06-19T02:23:22Z [Term] id: GO:0070740 name: tubulin-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510] synonym: "tubulin glutamylase activity" EXACT [GOC:mah] synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-8865774 "TTLLs polyglutamylate tubulin" xref: Reactome:R-HSA-8955869 "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin" is_a: GO:0070739 ! protein-glutamic acid ligase activity created_by: midori creation_date: 2009-06-19T02:26:15Z [Term] id: GO:0070741 name: response to interleukin-6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] synonym: "response to IL-6" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-06-19T03:39:12Z [Term] id: GO:0070742 name: C2H2 zinc finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-06-23T11:26:02Z [Term] id: GO:0070743 name: interleukin-23 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093] comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12. synonym: "IL-23 complex" EXACT [GOC:add] synonym: "IL12B" NARROW [GOC:add] synonym: "IL23A" NARROW [GOC:add] synonym: "p19" NARROW [GOC:add] synonym: "p40" NARROW [GOC:add] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: midori creation_date: 2009-06-23T01:06:02Z [Term] id: GO:0070744 name: interleukin-27 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428] comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits. synonym: "EBI3" NARROW [GOC:add] synonym: "IL-27 complex" EXACT [GOC:add] synonym: "IL27" NARROW [GOC:add] synonym: "p28" NARROW [GOC:add] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: midori creation_date: 2009-06-23T01:09:58Z [Term] id: GO:0070745 name: interleukin-35 complex namespace: cellular_component def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429] comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene. synonym: "EBI3" NARROW [GOC:add] synonym: "IL-35 complex" EXACT [GOC:add] synonym: "IL12A" NARROW [GOC:add] synonym: "p35" NARROW [GOC:add] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: midori creation_date: 2009-06-23T01:13:14Z [Term] id: GO:0070746 name: interleukin-35 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-35." [GOC:add] synonym: "IL-35 binding" EXACT [GOC:add] is_a: GO:0019955 ! cytokine binding created_by: midori creation_date: 2009-06-23T01:15:36Z [Term] id: GO:0070747 name: interleukin-35 receptor activity namespace: molecular_function def: "Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling] synonym: "IL-35 receptor activity" EXACT [GOC:add] synonym: "IL-35R" EXACT [GOC:add] is_a: GO:0004896 ! cytokine receptor activity relationship: has_part GO:0070746 ! interleukin-35 binding relationship: part_of GO:0070757 ! interleukin-35-mediated signaling pathway created_by: midori creation_date: 2009-06-23T01:18:09Z [Term] id: GO:0070748 name: interleukin-35 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-35 receptor." [GOC:add] synonym: "IL-35" NARROW [GOC:add] synonym: "interleukin-35 receptor ligand" NARROW [GOC:add] is_a: GO:0005126 ! cytokine receptor binding created_by: midori creation_date: 2009-06-23T01:21:54Z [Term] id: GO:0070749 name: interleukin-35 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "IL-35 biosynthesis" EXACT [GOC:mah] synonym: "IL-35 biosynthetic process" EXACT [GOC:add] synonym: "interleukin-35 anabolism" EXACT [GOC:mah] synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "interleukin-35 formation" EXACT [GOC:mah] synonym: "interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0070753 ! interleukin-35 production created_by: midori creation_date: 2009-06-23T01:25:11Z [Term] id: GO:0070750 name: regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0070754 ! regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070749 ! interleukin-35 biosynthetic process relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process created_by: midori creation_date: 2009-06-23T01:29:17Z [Term] id: GO:0070751 name: negative regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process is_a: GO:0070755 ! negative regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process created_by: midori creation_date: 2009-06-23T01:34:54Z [Term] id: GO:0070752 name: positive regulation of interleukin-35 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add] synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah] synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah] synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process is_a: GO:0070756 ! positive regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process created_by: midori creation_date: 2009-06-23T01:39:45Z [Term] id: GO:0070753 name: interleukin-35 production namespace: biological_process def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-35 production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production created_by: midori creation_date: 2009-06-23T01:42:04Z [Term] id: GO:0070754 name: regulation of interleukin-35 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "regulation of IL-35 production" EXACT [GOC:add] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070753 ! interleukin-35 production relationship: regulates GO:0070753 ! interleukin-35 production created_by: midori creation_date: 2009-06-23T01:44:37Z [Term] id: GO:0070755 name: negative regulation of interleukin-35 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah] synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah] synonym: "negative regulation of IL-35 production" EXACT [GOC:add] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0070754 ! regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070753 ! interleukin-35 production relationship: negatively_regulates GO:0070753 ! interleukin-35 production created_by: midori creation_date: 2009-06-23T01:48:25Z [Term] id: GO:0070756 name: positive regulation of interleukin-35 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "activation of interleukin-35 production" NARROW [GOC:mah] synonym: "positive regulation of IL-35 production" EXACT [GOC:add] synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah] synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0070754 ! regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070753 ! interleukin-35 production relationship: positively_regulates GO:0070753 ! interleukin-35 production created_by: midori creation_date: 2009-06-23T01:52:31Z [Term] id: GO:0070757 name: interleukin-35-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:mah, GOC:signaling] synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: midori creation_date: 2009-06-23T01:55:02Z [Term] id: GO:0070758 name: regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor." [GOC:mah] synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah] synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070757 ! interleukin-35-mediated signaling pathway relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway created_by: midori creation_date: 2009-06-23T01:58:43Z [Term] id: GO:0070759 name: negative regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway created_by: midori creation_date: 2009-06-23T02:02:07Z [Term] id: GO:0070760 name: positive regulation of interleukin-35-mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway created_by: midori creation_date: 2009-06-23T02:06:16Z [Term] id: GO:0070761 name: pre-snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390] synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl] is_a: GO:1990904 ! ribonucleoprotein complex created_by: midori creation_date: 2009-06-23T02:32:10Z [Term] id: GO:0070762 name: nuclear pore transmembrane ring namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "NDC1 complex" EXACT [] synonym: "NDC1 subcomplex" EXACT [PMID:19414609] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005643 ! nuclear pore created_by: midori creation_date: 2009-06-29T11:02:56Z [Term] id: GO:0070763 name: Delta1 complex namespace: cellular_component def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186] synonym: "Delta1 homodimer complex" EXACT [CORUM:3271] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T01:04:12Z [Term] id: GO:0070764 name: gamma-secretase-Delta1 complex namespace: cellular_component def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T01:11:51Z [Term] id: GO:0070765 name: gamma-secretase complex namespace: cellular_component def: "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368] synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142] synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466] synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468] synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" RELATED [CORUM:3128] synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T01:33:19Z [Term] id: GO:0070766 name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex namespace: cellular_component def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549] synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876] synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876] is_a: GO:0031201 ! SNARE complex created_by: midori creation_date: 2009-06-29T04:41:55Z [Term] id: GO:0070767 name: BRCA1-Rad51 complex namespace: cellular_component def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2009-06-29T05:04:21Z [Term] id: GO:0070768 name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex namespace: cellular_component def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968] synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873] synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873] is_a: GO:0031201 ! SNARE complex created_by: midori creation_date: 2009-06-29T05:14:04Z [Term] id: GO:0070769 name: alphaIIb-beta3 integrin-CIB complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514] synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T05:20:01Z [Term] id: GO:0070770 name: alphaIIb-beta3 integrin-CD47-FAK complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439] synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T05:43:59Z [Term] id: GO:0070771 name: alphaIIb-beta3 integrin-CD47-Src complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439] synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-06-29T05:46:53Z [Term] id: GO:0070772 name: PAS complex namespace: cellular_component def: "A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662] synonym: "autophagy-specific phosphatidylinositol 3-kinase complex" RELATED [PMID:24165940] is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III relationship: part_of GO:0005774 ! vacuolar membrane created_by: midori creation_date: 2009-06-30T11:13:32Z [Term] id: GO:0070773 name: protein-N-terminal glutamine amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein." [PMID:19560421] synonym: "NtQ-amidase activity" EXACT [PMID:19560421] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: midori creation_date: 2009-06-30T11:34:08Z [Term] id: GO:0070774 name: phytoceramidase activity namespace: molecular_function def: "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846] xref: KEGG_REACTION:R06528 xref: MetaCyc:CERAMIDASE-YEAST-RXN xref: Reactome:R-HSA-428262 "phytoceramide + H2O => stearate + phytosphingosine" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! N-acylsphingosine amidohydrolase activity created_by: midori creation_date: 2009-07-02T10:52:42Z [Term] id: GO:0070775 name: H3 histone acetyltransferase complex namespace: cellular_component def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah] synonym: "H3 HAT complex" EXACT [GOC:mah] is_a: GO:0000123 ! histone acetyltransferase complex created_by: midori creation_date: 2009-07-02T11:56:48Z [Term] id: GO:0070776 name: MOZ/MORF histone acetyltransferase complex namespace: cellular_component def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358] is_a: GO:0070775 ! H3 histone acetyltransferase complex created_by: midori creation_date: 2009-07-02T12:06:04Z [Term] id: GO:0070777 name: D-aspartate transport namespace: biological_process def: "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17364, GOC:mah, GOC:rph] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0042940 ! D-amino acid transport created_by: midori creation_date: 2009-07-02T01:42:57Z [Term] id: GO:0070778 name: L-aspartate transmembrane transport namespace: biological_process alt_id: GO:0089712 def: "The directed movement of L-aspartate across a membrane." [PMID:21307582] synonym: "L-aspartate transport" BROAD [] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: midori creation_date: 2009-07-02T01:46:31Z [Term] id: GO:0070779 name: D-aspartate import across plasma membrane namespace: biological_process alt_id: GO:0140016 def: "The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:7914198] synonym: "D-aspartate import" BROAD [] synonym: "D-aspartate import into cell" EXACT [] synonym: "D-aspartate uptake" EXACT [GOC:mah] is_a: GO:0070777 ! D-aspartate transport is_a: GO:0089718 ! amino acid import across plasma membrane created_by: midori creation_date: 2009-07-02T01:57:00Z [Term] id: GO:0070780 name: dihydrosphingosine-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058] synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah] synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah] xref: MetaCyc:RXN3DJ-25 xref: Reactome:R-HSA-428664 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate" is_a: GO:0016791 ! phosphatase activity created_by: midori creation_date: 2009-07-02T02:13:49Z [Term] id: GO:0070781 name: response to biotin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl] synonym: "response to Bios IIB" EXACT [GOC:sl] synonym: "response to coenzyme R" EXACT [GOC:sl] synonym: "response to vitamin B7" EXACT [GOC:sl] synonym: "response to vitamin H" EXACT [GOC:sl] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2009-07-02T02:34:43Z [Term] id: GO:0070782 name: phosphatidylserine exposure on apoptotic cell surface namespace: biological_process def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005] comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure. synonym: "externalization of phosphatidylserine" EXACT [GOC:rk] is_a: GO:0017121 ! plasma membrane phospholipid scrambling relationship: has_part GO:0017128 ! phospholipid scramblase activity relationship: part_of GO:0097194 ! execution phase of apoptosis created_by: midori creation_date: 2009-07-02T02:41:44Z [Term] id: GO:0070783 name: growth of unicellular organism as a thread of attached cells namespace: biological_process def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc] subset: goslim_candida is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: midori creation_date: 2009-07-07T02:21:14Z [Term] id: GO:0070784 name: regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells created_by: midori creation_date: 2009-07-07T02:34:59Z [Term] id: GO:0070785 name: negative regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells created_by: midori creation_date: 2009-07-07T02:37:21Z [Term] id: GO:0070786 name: positive regulation of growth of unicellular organism as a thread of attached cells namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells created_by: midori creation_date: 2009-07-07T02:39:48Z [Term] id: GO:0070787 name: conidiophore development namespace: biological_process def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886] is_a: GO:0075259 ! spore-bearing structure development created_by: midori creation_date: 2009-07-08T01:30:36Z [Term] id: GO:0070788 name: conidiophore stalk development namespace: biological_process def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T01:31:44Z [Term] id: GO:0070789 name: metula development namespace: biological_process def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886] synonym: "development of primary sterigmata" EXACT [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development relationship: part_of GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T01:33:46Z [Term] id: GO:0070790 name: phialide development namespace: biological_process def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886] synonym: "development of secondary sterigmata" EXACT [PMID:9529886] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development relationship: part_of GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T02:32:30Z [Term] id: GO:0070791 name: cleistothecium development namespace: biological_process def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882] is_a: GO:0000909 ! sporocarp development involved in sexual reproduction created_by: midori creation_date: 2009-07-08T02:52:32Z [Term] id: GO:0070792 name: Hulle cell development namespace: biological_process def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625] synonym: "Huelle cell development" EXACT [GOC:mah] synonym: "Hulle cell formation" NARROW [PMID:19210625] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048468 ! cell development relationship: part_of GO:0070791 ! cleistothecium development created_by: midori creation_date: 2009-07-08T02:54:30Z [Term] id: GO:0070793 name: regulation of conidiophore development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070787 ! conidiophore development relationship: regulates GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T03:04:29Z [Term] id: GO:0070794 name: negative regulation of conidiophore development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development is_a: GO:0075262 ! negative regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070787 ! conidiophore development relationship: negatively_regulates GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T03:06:48Z [Term] id: GO:0070795 name: positive regulation of conidiophore development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development is_a: GO:0075261 ! positive regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070787 ! conidiophore development relationship: positively_regulates GO:0070787 ! conidiophore development created_by: midori creation_date: 2009-07-08T03:08:29Z [Term] id: GO:0070796 name: regulation of cleistothecium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070791 ! cleistothecium development relationship: regulates GO:0070791 ! cleistothecium development created_by: midori creation_date: 2009-07-08T03:30:04Z [Term] id: GO:0070797 name: negative regulation of cleistothecium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:0070796 ! regulation of cleistothecium development is_a: GO:1902059 ! negative regulation of sporocarp development involved in sexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070791 ! cleistothecium development relationship: negatively_regulates GO:0070791 ! cleistothecium development created_by: midori creation_date: 2009-07-08T03:36:12Z [Term] id: GO:0070798 name: positive regulation of cleistothecium development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] is_a: GO:0070796 ! regulation of cleistothecium development is_a: GO:1902060 ! positive regulation of sporocarp development involved in sexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070791 ! cleistothecium development relationship: positively_regulates GO:0070791 ! cleistothecium development created_by: midori creation_date: 2009-07-08T03:36:43Z [Term] id: GO:0070799 name: regulation of conidiophore stalk development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0070793 ! regulation of conidiophore development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070788 ! conidiophore stalk development relationship: regulates GO:0070788 ! conidiophore stalk development created_by: midori creation_date: 2009-07-08T04:03:40Z [Term] id: GO:0070800 name: negative regulation of conidiophore stalk development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0070794 ! negative regulation of conidiophore development is_a: GO:0070799 ! regulation of conidiophore stalk development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070788 ! conidiophore stalk development relationship: negatively_regulates GO:0070788 ! conidiophore stalk development created_by: midori creation_date: 2009-07-08T04:10:42Z [Term] id: GO:0070801 name: positive regulation of conidiophore stalk development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] is_a: GO:0070795 ! positive regulation of conidiophore development is_a: GO:0070799 ! regulation of conidiophore stalk development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070788 ! conidiophore stalk development relationship: positively_regulates GO:0070788 ! conidiophore stalk development created_by: midori creation_date: 2009-07-08T04:11:22Z [Term] id: GO:0070802 name: regulation of metula development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070793 ! regulation of conidiophore development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070789 ! metula development relationship: regulates GO:0070789 ! metula development created_by: midori creation_date: 2009-07-08T04:14:34Z [Term] id: GO:0070803 name: negative regulation of metula development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070794 ! negative regulation of conidiophore development is_a: GO:0070802 ! regulation of metula development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070789 ! metula development relationship: negatively_regulates GO:0070789 ! metula development created_by: midori creation_date: 2009-07-08T04:38:04Z [Term] id: GO:0070804 name: positive regulation of metula development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070795 ! positive regulation of conidiophore development is_a: GO:0070802 ! regulation of metula development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070789 ! metula development relationship: positively_regulates GO:0070789 ! metula development created_by: midori creation_date: 2009-07-08T04:38:33Z [Term] id: GO:0070805 name: regulation of phialide development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070793 ! regulation of conidiophore development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070790 ! phialide development relationship: regulates GO:0070790 ! phialide development created_by: midori creation_date: 2009-07-08T04:45:03Z [Term] id: GO:0070806 name: negative regulation of phialide development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070794 ! negative regulation of conidiophore development is_a: GO:0070805 ! regulation of phialide development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070790 ! phialide development relationship: negatively_regulates GO:0070790 ! phialide development created_by: midori creation_date: 2009-07-08T04:47:16Z [Term] id: GO:0070807 name: positive regulation of phialide development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070795 ! positive regulation of conidiophore development is_a: GO:0070805 ! regulation of phialide development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070790 ! phialide development relationship: positively_regulates GO:0070790 ! phialide development created_by: midori creation_date: 2009-07-08T04:48:08Z [Term] id: GO:0070808 name: regulation of Hulle cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0060284 ! regulation of cell development is_a: GO:0070796 ! regulation of cleistothecium development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070792 ! Hulle cell development relationship: regulates GO:0070792 ! Hulle cell development created_by: midori creation_date: 2009-07-08T04:51:33Z [Term] id: GO:0070809 name: negative regulation of Hulle cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0070797 ! negative regulation of cleistothecium development is_a: GO:0070808 ! regulation of Hulle cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070792 ! Hulle cell development relationship: negatively_regulates GO:0070792 ! Hulle cell development created_by: midori creation_date: 2009-07-08T04:53:11Z [Term] id: GO:0070810 name: positive regulation of Hulle cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0070798 ! positive regulation of cleistothecium development is_a: GO:0070808 ! regulation of Hulle cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070792 ! Hulle cell development relationship: positively_regulates GO:0070792 ! Hulle cell development created_by: midori creation_date: 2009-07-08T04:54:12Z [Term] id: GO:0070811 name: glycerol-2-phosphate transmembrane transport namespace: biological_process def: "The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah] synonym: "glycerol-2-phosphate transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport created_by: midori creation_date: 2009-07-08T04:57:38Z [Term] id: GO:0070812 name: ATPase-coupled glycerol-2-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-2-phosphate(out) = ADP + phosphate + glycerol-2-phosphate(in)." [GOC:mah] synonym: "ATP-dependent glycerol-2-phosphate transmembrane transporter activity" EXACT [] synonym: "glycerol-2-phosphate-transporting ATPase activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0070811 ! glycerol-2-phosphate transmembrane transport created_by: midori creation_date: 2009-07-08T05:01:33Z [Term] id: GO:0070813 name: hydrogen sulfide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009404 ! toxin metabolic process is_a: GO:0017144 ! drug metabolic process created_by: midori creation_date: 2009-07-09T10:37:32Z [Term] id: GO:0070814 name: hydrogen sulfide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah] synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulfide formation" EXACT [GOC:mah] synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0070813 ! hydrogen sulfide metabolic process created_by: midori creation_date: 2009-07-09T10:45:02Z [Term] id: GO:0070815 name: peptidyl-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390] synonym: "lysine hydroxylase activity" BROAD [GOC:mah] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah] synonym: "lysyl hydroxylase activity" BROAD [GOC:mah] synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah] synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah] synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah] synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: midori creation_date: 2009-07-09T11:42:07Z [Term] id: GO:0070816 name: phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process alt_id: GO:0016245 def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc] synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2009-07-13T04:01:19Z [Term] id: GO:0070817 name: P-TEFb-cap methyltransferase complex localization namespace: biological_process def: "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH] synonym: "P-TEFb-cap methyltransferase complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization created_by: midori creation_date: 2009-07-13T04:20:17Z [Term] id: GO:0070818 name: protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor." [EC:1.3.3.4, GOC:mah, PMID:19583219] synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4] synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors created_by: midori creation_date: 2009-07-20T02:41:12Z [Term] id: GO:0070819 name: menaquinone-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone." [GOC:mah, PMID:19583219] synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah] is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity created_by: midori creation_date: 2009-07-20T02:46:06Z [Term] id: GO:0070820 name: tertiary granule namespace: cellular_component def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] synonym: "gelatinase granule" EXACT [PMID:23650620] is_a: GO:0030141 ! secretory granule created_by: midori creation_date: 2009-07-20T03:57:00Z [Term] id: GO:0070821 name: tertiary granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0070820 ! tertiary granule created_by: midori creation_date: 2009-07-20T03:59:41Z [Term] id: GO:0070822 name: Sin3-type complex namespace: cellular_component def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin created_by: midori creation_date: 2009-07-20T04:32:33Z [Term] id: GO:0070823 name: HDA1 complex namespace: cellular_component def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin created_by: midori creation_date: 2009-07-20T04:47:11Z [Term] id: GO:0070824 name: SHREC complex namespace: cellular_component def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: midori creation_date: 2009-07-20T05:02:12Z [Term] id: GO:0070825 name: micropyle namespace: cellular_component def: "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0042600 ! chorion created_by: midori creation_date: 2009-07-21T05:33:09Z [Term] id: GO:0070826 name: paraferritin complex namespace: cellular_component def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-07-23T03:05:08Z [Term] id: GO:0070827 name: chromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0006325 ! chromatin organization is_a: GO:0043954 ! cellular component maintenance created_by: midori creation_date: 2009-07-23T04:09:59Z [Term] id: GO:0070828 name: heterochromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] synonym: "heterochromatin organisation" EXACT [GOC:mah] is_a: GO:0006325 ! chromatin organization created_by: midori creation_date: 2009-07-23T04:12:48Z [Term] id: GO:0070829 name: heterochromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0070827 ! chromatin maintenance is_a: GO:0070828 ! heterochromatin organization created_by: midori creation_date: 2009-07-23T04:14:49Z [Term] id: GO:0070830 name: bicellular tight junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah] synonym: "tight junction formation" EXACT [GOC:mah] is_a: GO:0120192 ! tight junction assembly relationship: part_of GO:0043297 ! apical junction assembly created_by: midori creation_date: 2009-07-23T04:32:38Z [Term] id: GO:0070831 name: basement membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. is_a: GO:0071711 ! basement membrane organization is_a: GO:0085029 ! extracellular matrix assembly created_by: midori creation_date: 2009-07-23T05:01:51Z [Term] id: GO:0070832 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2] xref: MetaCyc:PWY4FS-2 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: midori creation_date: 2009-07-29T03:49:14Z [Term] id: GO:0070833 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3] xref: MetaCyc:PWY4FS-3 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process is_a: GO:1901160 ! primary amino compound metabolic process created_by: midori creation_date: 2009-07-29T03:51:39Z [Term] id: GO:0070834 name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4] xref: MetaCyc:PWY4FS-4 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: midori creation_date: 2009-07-29T03:54:47Z [Term] id: GO:0070835 name: chromium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah, GOC:yaf] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity created_by: midori creation_date: 2009-07-30T03:04:09Z [Term] id: GO:0070836 name: caveola assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858] synonym: "caveola formation" EXACT [GOC:mah] synonym: "caveolar biogenesis" RELATED [PMID:12633858] is_a: GO:0044854 ! plasma membrane raft assembly created_by: midori creation_date: 2009-07-30T04:45:54Z [Term] id: GO:0070837 name: dehydroascorbic acid transport namespace: biological_process def: "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl] synonym: "dehydroascorbate transport" EXACT [GOC:sl] is_a: GO:0015711 ! organic anion transport is_a: GO:0051180 ! vitamin transport created_by: midori creation_date: 2009-07-30T05:24:31Z [Term] id: GO:0070838 name: divalent metal ion transport namespace: biological_process def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0030001 ! metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport created_by: midori creation_date: 2009-07-31T01:02:39Z [Term] id: GO:0070839 name: divalent metal ion export namespace: biological_process def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle." [GOC:mah] is_a: GO:0070838 ! divalent metal ion transport created_by: midori creation_date: 2009-07-31T01:07:46Z [Term] id: GO:0070840 name: dynein complex binding namespace: molecular_function alt_id: GO:0045502 def: "Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah] synonym: "dynein binding" RELATED [] is_a: GO:0044877 ! protein-containing complex binding created_by: midori creation_date: 2009-07-31T01:22:47Z [Term] id: GO:0070841 name: inclusion body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] is_a: GO:0022607 ! cellular component assembly created_by: midori creation_date: 2009-07-31T01:28:14Z [Term] id: GO:0070842 name: aggresome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537] is_a: GO:0070841 ! inclusion body assembly created_by: midori creation_date: 2009-07-31T01:30:25Z [Term] id: GO:0070843 name: misfolded protein transport namespace: biological_process def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] is_a: GO:0006886 ! intracellular protein transport created_by: midori creation_date: 2009-07-31T12:50:00Z [Term] id: GO:0070844 name: polyubiquitinated protein transport namespace: biological_process def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] synonym: "polyubiquitylated protein transport" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport created_by: midori creation_date: 2009-07-31T12:51:10Z [Term] id: GO:0070845 name: polyubiquitinated misfolded protein transport namespace: biological_process def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah] synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah] is_a: GO:0070843 ! misfolded protein transport is_a: GO:0070844 ! polyubiquitinated protein transport created_by: midori creation_date: 2009-07-31T12:52:26Z [Term] id: GO:0070846 name: Hsp90 deacetylation namespace: biological_process def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah] is_a: GO:0006476 ! protein deacetylation created_by: midori creation_date: 2009-07-31T12:58:47Z [Term] id: GO:0070847 name: core mediator complex namespace: cellular_component def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] comment: Changed subclasses, see https://github.com/geneontology/go-ontology/issues/15979 synonym: "C mediator complex" EXACT [PMID:17870225] synonym: "S mediator complex" EXACT [PMID:17043218] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-08-04T02:56:11Z [Term] id: GO:0070848 name: response to growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] synonym: "response to growth factor stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance created_by: midori creation_date: 2009-08-04T04:24:18Z [Term] id: GO:0070849 name: response to epidermal growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah] synonym: "response to EGF stimulus" EXACT [GOC:mah] synonym: "response to epidermal growth factor stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: midori creation_date: 2009-08-04T04:26:26Z [Term] id: GO:0070850 name: TACC/TOG complex namespace: cellular_component def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-08-05T03:06:08Z [Term] id: GO:0070851 name: growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a growth factor receptor." [GOC:mah, GOC:vw] is_a: GO:0005102 ! signaling receptor binding created_by: midori creation_date: 2009-08-07T11:23:02Z [Term] id: GO:0070852 name: cell body fiber namespace: cellular_component def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah] synonym: "cell body fibre" EXACT [] synonym: "primary neurite" RELATED [GOC:dos, GOC:mah] is_a: GO:0043005 ! neuron projection created_by: midori creation_date: 2009-08-11T04:38:53Z [Term] id: GO:0070853 name: myosin VI binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855] is_a: GO:0017022 ! myosin binding created_by: midori creation_date: 2009-08-13T01:28:36Z [Term] id: GO:0070854 name: myosin VI heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin VI complex." [GOC:sart] is_a: GO:0032036 ! myosin heavy chain binding is_a: GO:0070853 ! myosin VI binding created_by: midori creation_date: 2009-08-13T01:44:05Z [Term] id: GO:0070855 name: myosin VI head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin VI heavy chain." [GOC:sart] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0070854 ! myosin VI heavy chain binding created_by: midori creation_date: 2009-08-13T01:45:08Z [Term] id: GO:0070856 name: myosin VI light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin VI complex." [GOC:sart] is_a: GO:0032027 ! myosin light chain binding is_a: GO:0070853 ! myosin VI binding created_by: midori creation_date: 2009-08-13T01:46:13Z [Term] id: GO:0070857 name: regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "regulation of bile acid formation" EXACT [GOC:mah] synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006699 ! bile acid biosynthetic process relationship: regulates GO:0006699 ! bile acid biosynthetic process created_by: midori creation_date: 2009-08-14T03:09:02Z [Term] id: GO:0070858 name: negative regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process is_a: GO:1904252 ! negative regulation of bile acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006699 ! bile acid biosynthetic process relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process created_by: midori creation_date: 2009-08-14T03:16:40Z [Term] id: GO:0070859 name: positive regulation of bile acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0070857 ! regulation of bile acid biosynthetic process is_a: GO:1904253 ! positive regulation of bile acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006699 ! bile acid biosynthetic process relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process created_by: midori creation_date: 2009-08-14T03:22:58Z [Term] id: GO:0070860 name: RNA polymerase I core factor complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872] comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does. is_a: GO:0000120 ! RNA polymerase I transcription factor complex created_by: midori creation_date: 2009-08-14T05:00:44Z [Term] id: GO:0070861 name: regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "regulation of protein exit from ER" EXACT [GOC:mah] synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "regulation of protein export from ER" EXACT [GOC:mah] is_a: GO:0033157 ! regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032527 ! protein exit from endoplasmic reticulum relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum created_by: midori creation_date: 2009-08-17T03:39:18Z [Term] id: GO:0070862 name: negative regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah] synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "negative regulation of protein export from ER" EXACT [GOC:mah] is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum is_a: GO:0090317 ! negative regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum created_by: midori creation_date: 2009-08-17T03:45:56Z [Term] id: GO:0070863 name: positive regulation of protein exit from endoplasmic reticulum namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah] synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah] synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "positive regulation of protein export from ER" EXACT [GOC:mah] synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum is_a: GO:0090316 ! positive regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum created_by: midori creation_date: 2009-08-17T03:50:04Z [Term] id: GO:0070864 name: sperm individualization complex namespace: cellular_component def: "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716] is_a: GO:0032991 ! protein-containing complex created_by: midori creation_date: 2009-08-19T01:25:33Z [Term] id: GO:0070865 name: investment cone namespace: cellular_component def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] synonym: "F-actin cone" EXACT [PMID:15829565] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0070864 ! sperm individualization complex created_by: midori creation_date: 2009-08-19T01:29:33Z [Term] id: GO:0070866 name: sterol-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) in the presence of sterols." [GOC:ecd] is_a: GO:0005515 ! protein binding created_by: midori creation_date: 2009-08-19T01:43:35Z [Term] id: GO:0070867 name: mating projection tip membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah] synonym: "mating projection membrane fusion domain" EXACT [PMID:29134248] synonym: "shmoo tip membrane" NARROW [GOC:mah] is_a: GO:0031520 ! plasma membrane of cell tip intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0043332 ! mating projection tip relationship: part_of GO:0043332 ! mating projection tip created_by: midori creation_date: 2009-08-19T04:05:58Z [Term] id: GO:0070868 name: heterochromatin organization involved in chromatin silencing namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] synonym: "heterochromatin organisation involved in chromatin silencing" EXACT [GOC:mah] is_a: GO:0070828 ! heterochromatin organization is_a: GO:0097549 ! chromatin organization involved in negative regulation of transcription intersection_of: GO:0070828 ! heterochromatin organization intersection_of: part_of GO:0006342 ! chromatin silencing relationship: part_of GO:0006342 ! chromatin silencing created_by: midori creation_date: 2009-08-20T12:45:52Z [Term] id: GO:0070869 name: heterochromatin assembly involved in chromatin silencing namespace: biological_process def: "Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing." [GOC:mah] synonym: "heterochromatin formation involved in chromatin silencing" EXACT [] is_a: GO:0031507 ! heterochromatin assembly is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing intersection_of: GO:0031507 ! heterochromatin assembly intersection_of: part_of GO:0006342 ! chromatin silencing created_by: midori creation_date: 2009-08-20T01:04:27Z [Term] id: GO:0070870 name: heterochromatin maintenance involved in chromatin silencing namespace: biological_process def: "A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing." [GOC:mah] is_a: GO:0070829 ! heterochromatin maintenance is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing intersection_of: GO:0070829 ! heterochromatin maintenance intersection_of: part_of GO:0006342 ! chromatin silencing created_by: midori creation_date: 2009-08-20T01:08:43Z [Term] id: GO:0070871 name: cell wall organization involved in conjugation with cellular fusion namespace: biological_process def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah] synonym: "cell wall organisation involved in conjugation with cellular fusion" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0071555 ! cell wall organization intersection_of: GO:0071555 ! cell wall organization intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2009-08-20T02:23:19Z [Term] id: GO:0070873 name: regulation of glycogen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005977 ! glycogen metabolic process relationship: regulates GO:0005977 ! glycogen metabolic process created_by: midori creation_date: 2009-08-20T02:44:53Z [Term] id: GO:0070874 name: negative regulation of glycogen metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005977 ! glycogen metabolic process relationship: negatively_regulates GO:0005977 ! glycogen metabolic process created_by: midori creation_date: 2009-08-20T02:50:41Z [Term] id: GO:0070875 name: positive regulation of glycogen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005977 ! glycogen metabolic process relationship: positively_regulates GO:0005977 ! glycogen metabolic process created_by: midori creation_date: 2009-08-20T02:53:55Z [Term] id: GO:0070876 name: SOSS complex namespace: cellular_component def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2009-08-20T03:30:48Z [Term] id: GO:0070877 name: microprocessor complex namespace: cellular_component def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994] xref: IntAct:EBI-9519039 xref: IntAct:EBI-9519056 is_a: GO:1903095 ! ribonuclease III complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2009-08-20T03:56:26Z [Term] id: GO:0070878 name: primary miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [GOC:sl, PMID:15531877, PMID:15574589] synonym: "pri-miRNA binding" EXACT [] synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589] is_a: GO:0003723 ! RNA binding created_by: midori creation_date: 2009-08-20T04:11:36Z [Term] id: GO:0070879 name: fungal-type cell wall beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah, GOC:vw] synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah] is_a: GO:0034406 ! cell wall beta-glucan metabolic process is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis created_by: midori creation_date: 2009-08-21T02:46:09Z [Term] id: GO:0070880 name: fungal-type cell wall beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah] synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah] is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process created_by: midori creation_date: 2009-08-21T02:48:24Z [Term] id: GO:0070881 name: regulation of proline transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah] is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015824 ! proline transport relationship: regulates GO:0015824 ! proline transport created_by: midori creation_date: 2009-08-21T04:48:34Z [Term] id: GO:0070883 name: pre-miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094] synonym: "pre-microRNA binding" EXACT [GOC:pr] synonym: "precursor microRNA binding" EXACT [PMID:18951094] is_a: GO:0003723 ! RNA binding created_by: midori creation_date: 2009-08-24T04:36:24Z [Term] id: GO:0070884 name: regulation of calcineurin-NFAT signaling cascade namespace: biological_process alt_id: GO:0051531 alt_id: GO:0051532 def: "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] synonym: "NFAT protein import into nucleus" NARROW [] synonym: "regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] synonym: "regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] synonym: "regulation of NFAT protein import into nucleus" NARROW [] is_a: GO:0106056 ! regulation of calcineurin-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033173 ! calcineurin-NFAT signaling cascade relationship: regulates GO:0033173 ! calcineurin-NFAT signaling cascade created_by: midori creation_date: 2009-08-26T03:25:30Z [Term] id: GO:0070885 name: negative regulation of calcineurin-NFAT signaling cascade namespace: biological_process alt_id: GO:0051534 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah] synonym: "down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] synonym: "down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] synonym: "downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] synonym: "inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] synonym: "inhibition of NFAT protein import into nucleus" NARROW [] synonym: "negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] synonym: "negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] synonym: "negative regulation of NFAT protein import into nucleus" NARROW [] synonym: "termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf] is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade is_a: GO:0106057 ! negative regulation of calcineurin-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade created_by: midori creation_date: 2009-08-26T03:29:33Z [Term] id: GO:0070886 name: positive regulation of calcineurin-NFAT signaling cascade namespace: biological_process alt_id: GO:0051533 def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah] synonym: "activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] synonym: "positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] synonym: "positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] synonym: "positive regulation of NFAT protein import into nucleus" NARROW [] synonym: "stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] synonym: "up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] synonym: "up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] synonym: "upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade is_a: GO:0106058 ! positive regulation of calcineurin-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade created_by: midori creation_date: 2009-08-26T03:37:10Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070888 name: E-box binding namespace: molecular_function def: "Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "E-box promoter binding" EXACT [GOC:vk] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: midori creation_date: 2009-08-28T10:37:01Z [Term] id: GO:0070889 name: platelet alpha granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220] synonym: "platelet alpha granule organisation" EXACT [GOC:mah] synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah] synonym: "platelet alpha-granule organization" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization created_by: midori creation_date: 2009-08-28T10:43:31Z [Term] id: GO:0070890 name: sodium-dependent L-ascorbate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143] is_a: GO:0008520 ! L-ascorbate:sodium symporter activity created_by: midori creation_date: 2009-09-01T02:25:22Z [Term] id: GO:0070891 name: lipoteichoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680] is_a: GO:0097367 ! carbohydrate derivative binding created_by: midori creation_date: 2009-09-01T02:56:36Z [Term] id: GO:0070892 name: lipoteichoic acid immune receptor activity namespace: molecular_function def: "Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response." [GOC:add, PMID:14665680] synonym: "lipoteichoic acid receptor activity" BROAD [] is_a: GO:0038187 ! pattern recognition receptor activity relationship: has_part GO:0070891 ! lipoteichoic acid binding created_by: midori creation_date: 2009-09-01T02:59:24Z [Term] id: GO:0070893 name: transposon integration namespace: biological_process def: "Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723] is_a: GO:0015074 ! DNA integration is_a: GO:0032196 ! transposition created_by: midori creation_date: 2009-09-01T04:08:19Z [Term] id: GO:0070894 name: regulation of transposon integration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] is_a: GO:0010528 ! regulation of transposition is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070893 ! transposon integration relationship: regulates GO:0070893 ! transposon integration created_by: midori creation_date: 2009-09-01T04:14:09Z [Term] id: GO:0070895 name: negative regulation of transposon integration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] synonym: "down regulation of transposon integration" EXACT [GOC:mah] synonym: "down-regulation of transposon integration" EXACT [GOC:mah] synonym: "downregulation of transposon integration" EXACT [GOC:mah] synonym: "inhibition of transposon integration" NARROW [GOC:mah] is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0070894 ! regulation of transposon integration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070893 ! transposon integration relationship: negatively_regulates GO:0070893 ! transposon integration created_by: midori creation_date: 2009-09-01T04:20:36Z [Term] id: GO:0070896 name: positive regulation of transposon integration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] synonym: "activation of transposon integration" NARROW [GOC:mah] synonym: "stimulation of transposon integration" NARROW [GOC:mah] synonym: "up regulation of transposon integration" EXACT [GOC:mah] synonym: "up-regulation of transposon integration" EXACT [GOC:mah] synonym: "upregulation of transposon integration" EXACT [GOC:mah] is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0070894 ! regulation of transposon integration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070893 ! transposon integration relationship: positively_regulates GO:0070893 ! transposon integration created_by: midori creation_date: 2009-09-01T04:25:06Z [Term] id: GO:0070897 name: transcription preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription." [GOC:jp, GOC:txnOH] synonym: "DNA-dependent transcriptional preinitiation complex assembly" EXACT [GOC:txnOH] synonym: "DNA-templated transcriptional preinitiation complex assembly" EXACT [] synonym: "transcription PIC biosynthesis" BROAD [GOC:mah] synonym: "transcription PIC formation" BROAD [GOC:mah] synonym: "transcriptional preinitiation complex formation" BROAD [GOC:mah] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006352 ! DNA-templated transcription, initiation created_by: midori creation_date: 2009-09-01T04:33:47Z [Term] id: GO:0070898 name: RNA polymerase III preinitiation complex assembly namespace: biological_process alt_id: GO:0000999 alt_id: GO:0001020 alt_id: GO:0001021 alt_id: GO:0001043 def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter." [GOC:jp, GOC:txnOH, PMID:11387215, PMID:12381659] synonym: "RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly" NARROW [] synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah] synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah] synonym: "RNA polymerase III transcriptional preinitiation complex assembly" EXACT [] synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah] synonym: "RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly" NARROW [] synonym: "RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly" NARROW [] synonym: "RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly" NARROW [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter created_by: midori creation_date: 2010-08-19T04:16:04Z [Term] id: GO:0070899 name: mitochondrial tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0070900 ! mitochondrial tRNA modification intersection_of: GO:0002098 ! tRNA wobble uridine modification intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2009-09-02T03:14:13Z [Term] id: GO:0070900 name: mitochondrial tRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc] is_a: GO:0006400 ! tRNA modification is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process is_a: GO:0090646 ! mitochondrial tRNA processing is_a: GO:1900864 ! mitochondrial RNA modification intersection_of: GO:0006400 ! tRNA modification intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2009-09-02T03:16:53Z [Term] id: GO:0070901 name: mitochondrial tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0030488 ! tRNA methylation is_a: GO:0070900 ! mitochondrial tRNA modification intersection_of: GO:0030488 ! tRNA methylation intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2009-09-02T04:08:00Z [Term] id: GO:0070902 name: mitochondrial tRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0031119 ! tRNA pseudouridine synthesis is_a: GO:0070900 ! mitochondrial tRNA modification intersection_of: GO:0031119 ! tRNA pseudouridine synthesis intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2009-09-02T04:09:48Z [Term] id: GO:0070903 name: mitochondrial tRNA thio-modification namespace: biological_process def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] is_a: GO:0034227 ! tRNA thio-modification is_a: GO:0070900 ! mitochondrial tRNA modification intersection_of: GO:0034227 ! tRNA thio-modification intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2009-09-02T04:11:17Z [Term] id: GO:0070904 name: transepithelial L-ascorbic acid transport namespace: biological_process def: "The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf] synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah] synonym: "transepithelial vitamin C transport" EXACT [GOC:mah] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0070633 ! transepithelial transport created_by: midori creation_date: 2009-09-03T02:21:25Z [Term] id: GO:0070905 name: serine binding namespace: molecular_function def: "Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid." [CHEBI:17822, GOC:rph] synonym: "Ser binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding created_by: midori creation_date: 2009-09-04T03:28:29Z [Term] id: GO:0070906 name: aspartate:alanine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh] synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah] synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah] xref: RHEA:33139 is_a: GO:0015298 ! solute:cation antiporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity created_by: midori creation_date: 2009-09-04T03:44:15Z [Term] id: GO:0070907 name: histidine:histamine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh] synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah] synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:1901474 ! azole transmembrane transporter activity created_by: midori creation_date: 2009-09-04T03:47:07Z [Term] id: GO:0070908 name: tyrosine:tyramine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh] synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah] synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah] is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity created_by: midori creation_date: 2009-09-04T03:49:45Z [Term] id: GO:0070909 name: glutamate:gamma-aminobutyric acid antiporter activity namespace: molecular_function def: "Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)." [GOC:dh] synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity created_by: midori creation_date: 2009-09-04T03:51:32Z [Term] id: GO:0070910 name: cell wall macromolecule catabolic process involved in cell wall disassembly namespace: biological_process def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah] is_a: GO:0016998 ! cell wall macromolecule catabolic process intersection_of: GO:0016998 ! cell wall macromolecule catabolic process intersection_of: part_of GO:0044277 ! cell wall disassembly relationship: part_of GO:0044277 ! cell wall disassembly created_by: midori creation_date: 2009-09-09T02:40:57Z [Term] id: GO:0070911 name: global genome nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354] synonym: "GG-NER" EXACT [PMID:10197977] synonym: "GGR" EXACT [GOC:vw, PMID:18794354] synonym: "global genome NER" EXACT [GOC:mah] synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw] synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354] is_a: GO:0006289 ! nucleotide-excision repair created_by: midori creation_date: 2009-09-09T03:13:11Z [Term] id: GO:0070912 name: Ddb1-Ckn1 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] is_a: GO:0000109 ! nucleotide-excision repair complex created_by: midori creation_date: 2009-09-09T03:41:04Z [Term] id: GO:0070913 name: Ddb1-Wdr21 complex namespace: cellular_component def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] is_a: GO:0000109 ! nucleotide-excision repair complex created_by: midori creation_date: 2009-09-09T03:47:54Z [Term] id: GO:0070914 name: UV-damage excision repair namespace: biological_process def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100] synonym: "AER" RELATED [GOC:mah, PMID:10704216] synonym: "alternative excision repair" RELATED [GOC:mah, PMID:10704216] synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw] synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100] synonym: "UVER" EXACT [GOC:vw, PMID:9619100] is_a: GO:0006281 ! DNA repair is_a: GO:0034644 ! cellular response to UV created_by: midori creation_date: 2009-09-10T03:14:06Z [Term] id: GO:0070915 name: lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:52288, GOC:bf, GOC:mah, PMID:15755723] synonym: "LPA receptor activity" EXACT [PMID:15755723] is_a: GO:0045125 ! bioactive lipid receptor activity relationship: has_part GO:0035727 ! lysophosphatidic acid binding created_by: midori creation_date: 2009-09-10T05:05:13Z [Term] id: GO:0070916 name: inositol phosphoceramide synthase complex namespace: cellular_component def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565] synonym: "IPC synthase complex" EXACT [GOC:mah] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005794 ! Golgi apparatus created_by: midori creation_date: 2009-09-10T05:23:21Z [Term] id: GO:0070917 name: inositol phosphoceramide synthase regulator activity namespace: molecular_function def: "Modulates the activity of inositol phosphoceramide synthase." [GOC:mah] comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "IPC synthase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: regulates GO:0045140 ! inositol phosphoceramide synthase activity created_by: midori creation_date: 2009-09-10T05:27:06Z [Term] id: GO:0070918 name: production of small RNA involved in gene silencing by RNA namespace: biological_process def: "The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." [GOC:mah, PMID:19239886] synonym: "gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] synonym: "gene silencing by RNA, production of small RNA" EXACT [GOC:mah] is_a: GO:0031050 ! dsRNA processing relationship: part_of GO:0031047 ! gene silencing by RNA created_by: midori creation_date: 2009-09-11T03:32:19Z [Term] id: GO:0070919 name: production of siRNA involved in chromatin silencing by small RNA namespace: biological_process def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT [] synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0031048 ! chromatin silencing by small RNA created_by: midori creation_date: 2009-09-11T03:39:18Z [Term] id: GO:0070920 name: regulation of production of small RNA involved in gene silencing by RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah] synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah] is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA created_by: midori creation_date: 2009-09-11T03:41:59Z [Term] id: GO:0070921 name: regulation of production of siRNA involved in chromatin silencing by small RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah] synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] is_a: GO:0010964 ! regulation of chromatin silencing by small RNA is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA relationship: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA created_by: midori creation_date: 2009-09-11T03:42:51Z [Term] id: GO:0070922 name: small RNA loading onto RISC namespace: biological_process def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "gene silencing by RNA, small RNA loading onto RISC" EXACT [GOC:mah] synonym: "RISC assembly" RELATED [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0031047 ! gene silencing by RNA created_by: midori creation_date: 2009-09-11T03:57:38Z [Term] id: GO:0070923 name: siRNA loading onto RISC involved in chromatin silencing by small RNA namespace: biological_process def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, siRNA loading onto RISC" EXACT [GOC:mah] is_a: GO:0070922 ! small RNA loading onto RISC relationship: part_of GO:0031048 ! chromatin silencing by small RNA created_by: midori creation_date: 2009-09-11T04:01:44Z [Term] id: GO:0070924 name: heterochromatin assembly involved in chromatin silencing by small RNA namespace: biological_process def: "The process in which an siRNA-associated RNA-induced silencing complex (siRISC) associates with nascent transcripts and RNA polymerase to induce the formation of heterochromatin." [GOC:mah, PMID:19239886] synonym: "chromatin silencing by small RNA, heterochromatin formation" EXACT [GOC:mah] synonym: "heterochromatin formation involved in chromatin silencing by small RNA" EXACT [] synonym: "small RNA-mediated heterochromatin biosynthesis" EXACT [GOC:mah] synonym: "small RNA-mediated heterochromatin formation" EXACT [GOC:mah] is_a: GO:0070869 ! heterochromatin assembly involved in chromatin silencing intersection_of: GO:0031507 ! heterochromatin assembly intersection_of: part_of GO:0031048 ! chromatin silencing by small RNA relationship: part_of GO:0031048 ! chromatin silencing by small RNA created_by: midori creation_date: 2009-09-11T04:10:51Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly created_by: midori creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070926 name: regulation of ATP:ADP antiporter activity namespace: biological_process def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1903959 ! regulation of anion transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005471 ! ATP:ADP antiporter activity relationship: regulates GO:0005471 ! ATP:ADP antiporter activity created_by: midori creation_date: 2009-09-16T02:56:35Z [Term] id: GO:0070927 name: negative regulation of ATP:ADP antiporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah] synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity relationship: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity created_by: midori creation_date: 2009-09-16T02:58:02Z [Term] id: GO:0070928 name: regulation of mRNA stability, ncRNA-mediated namespace: biological_process def: "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2] synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah] synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah] is_a: GO:0043488 ! regulation of mRNA stability created_by: midori creation_date: 2009-09-16T03:26:21Z [Term] id: GO:0070929 name: trans-translation namespace: biological_process def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah] is_a: GO:0006414 ! translational elongation created_by: midori creation_date: 2009-09-16T04:06:12Z [Term] id: GO:0070930 name: trans-translation-dependent protein tagging namespace: biological_process def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:jsg, GOC:mah] comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus. synonym: "co-translational protein tagging" EXACT [GOC:jh2, GOC:jsg] synonym: "cotranslational protein tagging" EXACT [GOC:mah] synonym: "protein modification by trans-translation" EXACT [GOC:mah] is_a: GO:0006464 ! cellular protein modification process relationship: has_part GO:0070929 ! trans-translation created_by: midori creation_date: 2009-09-16T04:10:49Z [Term] id: GO:0070931 name: Golgi-associated vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005798 ! Golgi-associated vesicle created_by: midori creation_date: 2009-09-16T04:26:50Z [Term] id: GO:0070932 name: histone H3 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] is_a: GO:0016575 ! histone deacetylation created_by: midori creation_date: 2009-09-16T04:50:55Z [Term] id: GO:0070933 name: histone H4 deacetylation namespace: biological_process def: "The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] is_a: GO:0016575 ! histone deacetylation created_by: midori creation_date: 2009-09-16T04:53:06Z [Term] id: GO:0070934 name: CRD-mediated mRNA stabilization namespace: biological_process def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah] is_a: GO:0048255 ! mRNA stabilization created_by: midori creation_date: 2009-09-21T02:57:06Z [Term] id: GO:0070935 name: 3'-UTR-mediated mRNA stabilization namespace: biological_process def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303] synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah] is_a: GO:0048255 ! mRNA stabilization created_by: midori creation_date: 2009-09-21T03:08:20Z [Term] id: GO:0070936 name: protein K48-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] synonym: "protein K48-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination created_by: midori creation_date: 2009-09-21T03:25:27Z [Term] id: GO:0070937 name: CRD-mediated mRNA stability complex namespace: cellular_component def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. synonym: "coding-region determinant of instability-mediated mRNA stability complex" EXACT [] synonym: "coding-region instability determinant -mediated mRNA stability complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-09-22T02:00:22Z [Term] id: GO:0070938 name: contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] synonym: "constriction ring" RELATED [GOC:mah] synonym: "cytokinetic ring" RELATED [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity created_by: midori creation_date: 2009-09-22T02:41:32Z [Term] id: GO:0070939 name: Dsl1/NZR complex namespace: cellular_component def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. synonym: "CATCHR family complex" BROAD [] synonym: "Dsl1p complex" EXACT [PMID:19151722] synonym: "NZR complex" EXACT [PMID:25364732] is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0005783 ! endoplasmic reticulum created_by: midori creation_date: 2009-09-22T03:41:38Z [Term] id: GO:0070940 name: dephosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0006470 ! protein dephosphorylation created_by: midori creation_date: 2009-09-29T04:34:14Z [Term] id: GO:0070941 name: eisosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane." [GOC:al, GOC:jp, GOC:mah, PMID:19564405] is_a: GO:0022607 ! cellular component assembly created_by: midori creation_date: 2009-09-30T02:49:30Z [Term] id: GO:0070942 name: neutrophil mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196] synonym: "neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002446 ! neutrophil mediated immunity created_by: midori creation_date: 2009-10-01T01:49:30Z [Term] id: GO:0070943 name: neutrophil mediated killing of symbiont cell namespace: biological_process def: "The directed killing of a symbiont target cell by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0051873 ! killing by host of symbiont cells is_a: GO:0070942 ! neutrophil mediated cytotoxicity created_by: midori creation_date: 2009-10-01T01:52:03Z [Term] id: GO:0070944 name: neutrophil mediated killing of bacterium namespace: biological_process def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: part_of GO:0042742 ! defense response to bacterium created_by: midori creation_date: 2009-10-01T01:55:56Z [Term] id: GO:0070945 name: neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070944 ! neutrophil mediated killing of bacterium relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium created_by: midori creation_date: 2009-10-01T01:59:12Z [Term] id: GO:0070946 name: neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070944 ! neutrophil mediated killing of bacterium relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium created_by: midori creation_date: 2009-10-01T02:04:15Z [Term] id: GO:0070947 name: neutrophil mediated killing of fungus namespace: biological_process def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196] is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: part_of GO:0050832 ! defense response to fungus created_by: midori creation_date: 2009-10-01T02:07:44Z [Term] id: GO:0070948 name: regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070942 ! neutrophil mediated cytotoxicity relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070949 name: regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0051709 ! regulation of killing of cells of other organism is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070950 name: regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070944 ! neutrophil mediated killing of bacterium relationship: regulates GO:0070944 ! neutrophil mediated killing of bacterium created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070951 name: regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium relationship: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070952 name: regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium relationship: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070953 name: regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:1900150 ! regulation of defense response to fungus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070947 ! neutrophil mediated killing of fungus relationship: regulates GO:0070947 ! neutrophil mediated killing of fungus created_by: midori creation_date: 2009-10-01T02:14:36Z [Term] id: GO:0070954 name: negative regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070955 name: negative regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0051711 ! negative regulation of killing of cells of other organism is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070956 name: negative regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell is_a: GO:1900425 ! negative regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium relationship: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070957 name: negative regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium relationship: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070958 name: negative regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium relationship: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070959 name: negative regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah] is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus relationship: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus created_by: midori creation_date: 2009-10-01T02:20:17Z [Term] id: GO:0070960 name: positive regulation of neutrophil mediated cytotoxicity namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add] synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070961 name: positive regulation of neutrophil mediated killing of symbiont cell namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell relationship: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070962 name: positive regulation of neutrophil mediated killing of bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell is_a: GO:1900426 ! positive regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium relationship: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070963 name: positive regulation of neutrophil mediated killing of gram-negative bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium relationship: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070964 name: positive regulation of neutrophil mediated killing of gram-positive bacterium namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium relationship: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070965 name: positive regulation of neutrophil mediated killing of fungus namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah] synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah] synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus relationship: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus created_by: midori creation_date: 2009-10-01T02:28:49Z [Term] id: GO:0070966 name: nuclear-transcribed mRNA catabolic process, no-go decay namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824] synonym: "no-go decay" EXACT [GOC:jp] synonym: "no-go mRNA decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp] synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process created_by: midori creation_date: 2009-10-01T02:36:22Z [Term] id: GO:0070967 name: coenzyme F420 binding namespace: molecular_function def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:16848, GOC:dh] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding created_by: midori creation_date: 2009-10-02T11:33:26Z [Term] id: GO:0070968 name: pyrroloquinoline quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [CHEBI:18315, GOC:dh] synonym: "PQQ binding" EXACT [GOC:dh] is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0048038 ! quinone binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: midori creation_date: 2009-10-02T11:39:13Z [Term] id: GO:0070970 name: interleukin-2 secretion namespace: biological_process def: "The regulated release of interleukin-2 from a cell." [GOC:mah, PMID:16930574] synonym: "IL-2 secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032623 ! interleukin-2 production created_by: midori creation_date: 2009-10-02T12:03:07Z [Term] id: GO:0070971 name: endoplasmic reticulum exit site namespace: cellular_component def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052] synonym: "ER exit site" EXACT [GOC:mah] synonym: "transitional ER" EXACT [PMID:15623529] xref: NIF_Subcellular:sao124393998 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005783 ! endoplasmic reticulum created_by: midori creation_date: 2009-10-02T12:19:23Z [Term] id: GO:0070972 name: protein localization to endoplasmic reticulum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah] synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein localization in endoplasmic reticulum" EXACT [] synonym: "protein localization in ER" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2009-10-02T12:43:34Z [Term] id: GO:0070973 name: protein localization to endoplasmic reticulum exit site namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah] synonym: "protein localisation to endoplasmic reticulum exit site" EXACT [GOC:mah] synonym: "protein localization to ER exit site" EXACT [GOC:mah] is_a: GO:0070972 ! protein localization to endoplasmic reticulum created_by: midori creation_date: 2009-10-02T12:45:41Z [Term] id: GO:0070974 name: POU domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-10-02T12:53:02Z [Term] id: GO:0070975 name: FHA domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253] synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-10-02T01:09:20Z [Term] id: GO:0070976 name: TIR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] subset: goslim_chembl synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-10-02T01:17:29Z [Term] id: GO:0070977 name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0048799 ! animal organ maturation relationship: part_of GO:0060348 ! bone development created_by: midori creation_date: 2009-10-05T04:35:31Z [Term] id: GO:0070978 name: voltage-gated calcium channel complex assembly namespace: biological_process def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: midori creation_date: 2009-10-06T04:51:13Z [Term] id: GO:0070979 name: protein K11-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135] is_a: GO:0000209 ! protein polyubiquitination created_by: midori creation_date: 2009-10-26T04:50:57Z [Term] id: GO:0070980 name: biphenyl catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [CHEBI:17097, PMID:16310831, PMID:16339959, UniPathway:UPA00155] synonym: "biphenyl breakdown" EXACT [GOC:mah] synonym: "biphenyl catabolism" EXACT [GOC:mah] synonym: "biphenyl degradation" EXACT [GOC:mah] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018879 ! biphenyl metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: midori creation_date: 2009-10-27T11:24:59Z [Term] id: GO:0070981 name: L-asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] synonym: "L-asparagine anabolism" EXACT [GOC:mah] synonym: "L-asparagine biosynthesis" EXACT [GOC:mah] synonym: "L-asparagine formation" EXACT [GOC:mah] synonym: "L-asparagine synthesis" EXACT [GOC:mah] is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0070982 ! L-asparagine metabolic process created_by: midori creation_date: 2009-10-27T12:59:42Z [Term] id: GO:0070982 name: L-asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [CHEBI:17196, GOC:mah] synonym: "L-asparagine metabolism" EXACT [GOC:mah] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0017144 ! drug metabolic process created_by: midori creation_date: 2009-10-27T01:03:46Z [Term] id: GO:0070983 name: dendrite guidance namespace: biological_process def: "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] synonym: "dendritic guidance" EXACT [GOC:sart] is_a: GO:0097485 ! neuron projection guidance relationship: part_of GO:0048813 ! dendrite morphogenesis created_by: midori creation_date: 2009-10-27T03:53:23Z [Term] id: GO:0070984 name: SET domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990] synonym: "SET binding" EXACT [GOC:sart] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-10-27T04:09:28Z [Term] id: GO:0070985 name: transcription factor TFIIK complex namespace: cellular_component def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] synonym: "cyclin H-CDK7 complex" RELATED [] synonym: "Mcs6/Mcs2/Pmh1 complex" NARROW [GOC:vw, PMID:19328067] synonym: "TFIIK complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex created_by: midori creation_date: 2009-10-27T04:19:37Z [Term] id: GO:0070986 name: left/right axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah] synonym: "left-right axis specification" EXACT [GOC:mah] synonym: "left/right axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0060972 ! left/right pattern formation created_by: midori creation_date: 2009-10-29T01:43:34Z [Term] id: GO:0070987 name: error-free translesion synthesis namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh] comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. is_a: GO:0019985 ! translesion synthesis created_by: midori creation_date: 2009-10-29T02:45:42Z [Term] id: GO:0070988 name: demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl] is_a: GO:0008152 ! metabolic process created_by: midori creation_date: 2009-10-29T03:12:51Z [Term] id: GO:0070989 name: oxidative demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] subset: goslim_chembl is_a: GO:0055114 ! oxidation-reduction process is_a: GO:0070988 ! demethylation created_by: midori creation_date: 2009-10-29T03:33:25Z [Term] id: GO:0070990 name: snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0043021 ! ribonucleoprotein complex binding created_by: midori creation_date: 2009-10-29T03:54:25Z [Term] id: GO:0070991 name: medium-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:BHF, GOC:mah] synonym: "MCAD activity" EXACT [GOC:mah] xref: EC:1.3.99 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity created_by: midori creation_date: 2009-10-29T04:11:49Z [Term] id: GO:0070992 name: translation initiation complex namespace: cellular_component def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-10-30T01:23:52Z [Term] id: GO:0070993 name: translation preinitiation complex namespace: cellular_component def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-10-30T01:25:00Z [Term] id: GO:0070994 name: detection of oxidative stress namespace: biological_process def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah] is_a: GO:0006979 ! response to oxidative stress created_by: midori creation_date: 2009-10-30T02:54:35Z [Term] id: GO:0070995 name: NADPH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah] synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah] synonym: "NADP (reduced) oxidation" EXACT [GOC:mah] synonym: "NADPH dehydrogenation" EXACT [GOC:mah] synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah] synonym: "reduced NADP oxidation" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah] synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0055114 ! oxidation-reduction process created_by: midori creation_date: 2009-11-03T12:02:15Z [Term] id: GO:0070996 name: type 1 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 melanocortin receptor." [GOC:BHF, GOC:mah] synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah] is_a: GO:0031779 ! melanocortin receptor binding created_by: midori creation_date: 2009-11-03T01:50:53Z [Term] id: GO:0070997 name: neuron death namespace: biological_process def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl] synonym: "neuronal cell death" EXACT [GOC:mah] is_a: GO:0008219 ! cell death created_by: midori creation_date: 2009-11-03T02:37:17Z [Term] id: GO:0070998 name: sensory perception of gravity namespace: biological_process def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah] is_a: GO:0007600 ! sensory perception created_by: midori creation_date: 2009-11-03T03:25:12Z [Term] id: GO:0070999 name: detection of mechanical stimulus involved in sensory perception of gravity namespace: biological_process def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah] is_a: GO:0009590 ! detection of gravity is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0070998 ! sensory perception of gravity relationship: part_of GO:0070998 ! sensory perception of gravity created_by: midori creation_date: 2009-11-03T03:27:30Z [Term] id: GO:0071000 name: response to magnetism namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl] synonym: "response to magnetic stimulus" EXACT [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus created_by: midori creation_date: 2009-11-04T12:02:03Z [Term] id: GO:0071001 name: U4/U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs." [GOC:mah, PMID:14685174] is_a: GO:0097525 ! spliceosomal snRNP complex relationship: has_part GO:0005687 ! U4 snRNP relationship: has_part GO:0005688 ! U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071002 name: U4atac/U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains base-paired U4atac and U6atac small nuclear RNAs." [GOC:mah, PMID:14685174] is_a: GO:0097525 ! spliceosomal snRNP complex relationship: has_part GO:0005690 ! U4atac snRNP relationship: has_part GO:0005691 ! U6atac snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071003 name: penta-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:11804584, PMID:12724403] synonym: "penta-RNP complex" EXACT [GOC:rb] is_a: GO:0097525 ! spliceosomal snRNP complex relationship: has_part GO:0005682 ! U5 snRNP relationship: has_part GO:0005685 ! U1 snRNP relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0071001 ! U4/U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071004 name: U2-type prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071010 ! prespliceosome relationship: has_part GO:0005685 ! U1 snRNP relationship: has_part GO:0005686 ! U2 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071005 name: U2-type precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071011 ! precatalytic spliceosome relationship: has_part GO:0005685 ! U1 snRNP relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0046540 ! U4/U6 x U5 tri-snRNP complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071006 name: U2-type catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071012 ! catalytic step 1 spliceosome relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005688 ! U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071007 name: U2-type catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071013 ! catalytic step 2 spliceosome relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005688 ! U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071008 name: U2-type post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "U2/U5/U6 snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941, PMID:24442611] synonym: "U2/U5/U6 tri-snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071014 ! post-mRNA release spliceosomal complex relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005688 ! U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071009 name: U4atac/U6atac x U5 tri-snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex formed by the association of the U4atac/U6atac and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:mah, GOC:pr, PMID:16201866] synonym: "U4atac/U6atac.U5 snRNP complex" EXACT [] is_a: GO:0097526 ! spliceosomal tri-snRNP complex relationship: has_part GO:0005682 ! U5 snRNP relationship: has_part GO:0071002 ! U4atac/U6atac snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071010 name: prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "prespliceosomal complex" EXACT [GOC:vw] synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071011 name: precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071012 name: catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex is_a: GO:1902494 ! catalytic complex relationship: has_part GO:0000974 ! Prp19 complex relationship: has_part GO:0005682 ! U5 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071013 name: catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex is_a: GO:1902494 ! catalytic complex relationship: has_part GO:0000974 ! Prp19 complex relationship: has_part GO:0005682 ! U5 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071014 name: post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex relationship: has_part GO:0005682 ! U5 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071015 name: U12-type prespliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866] synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071010 ! prespliceosome relationship: has_part GO:0034693 ! U11/U12 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071016 name: U12-type precatalytic spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866] synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071011 ! precatalytic spliceosome relationship: has_part GO:0005692 ! U11 snRNP relationship: has_part GO:0005693 ! U12 snRNP relationship: has_part GO:0071009 ! U4atac/U6atac x U5 tri-snRNP complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071017 name: U12-type catalytic step 1 spliceosome namespace: cellular_component def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071012 ! catalytic step 1 spliceosome relationship: has_part GO:0005691 ! U6atac snRNP relationship: has_part GO:0005693 ! U12 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071018 name: U12-type catalytic step 2 spliceosome namespace: cellular_component def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071013 ! catalytic step 2 spliceosome relationship: has_part GO:0005691 ! U6atac snRNP relationship: has_part GO:0005693 ! U12 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071019 name: U12-type post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0005691 ! U6atac snRNP is_a: GO:0005693 ! U12 snRNP is_a: GO:0071014 ! post-mRNA release spliceosomal complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071020 name: post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex relationship: has_part GO:0005682 ! U5 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071021 name: U2-type post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071020 ! post-spliceosomal complex relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005688 ! U6 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071022 name: U12-type post-spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005689 ! U12-type spliceosomal complex is_a: GO:0071020 ! post-spliceosomal complex relationship: has_part GO:0005691 ! U6atac snRNP relationship: has_part GO:0005693 ! U12 snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071023 name: trans spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex relationship: has_part GO:0005682 ! U5 snRNP relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005687 ! U4 snRNP relationship: has_part GO:0005688 ! U6 snRNP relationship: has_part GO:0071024 ! SL snRNP created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071024 name: SL snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA." [GOC:krc, ISBN:0879697393] is_a: GO:0097525 ! spliceosomal snRNP complex created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071025 name: RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0006401 ! RNA catabolic process created_by: kchris creation_date: 2009-07-28T03:10:28Z [Term] id: GO:0071026 name: cytoplasmic RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "cytoplasmic RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071025 ! RNA surveillance intersection_of: GO:0071025 ! RNA surveillance intersection_of: occurs_in GO:0005737 ! cytoplasm relationship: occurs_in GO:0005737 ! cytoplasm created_by: kchris creation_date: 2009-07-28T03:14:03Z [Term] id: GO:0071027 name: nuclear RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear RNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071025 ! RNA surveillance intersection_of: GO:0071025 ! RNA surveillance intersection_of: occurs_in GO:0005634 ! nucleus relationship: occurs_in GO:0005634 ! nucleus created_by: kchris creation_date: 2009-07-28T03:45:02Z [Term] id: GO:0071028 name: nuclear mRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0071027 ! nuclear RNA surveillance created_by: kchris creation_date: 2009-07-28T04:14:29Z [Term] id: GO:0071029 name: nuclear ncRNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear ncRNA quality control" EXACT [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0071027 ! nuclear RNA surveillance created_by: kchris creation_date: 2009-07-28T04:22:31Z [Term] id: GO:0071030 name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing namespace: biological_process def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance relationship: has_part GO:0071042 ! nuclear polyadenylation-dependent mRNA catabolic process created_by: kchris creation_date: 2009-07-28T04:24:04Z [Term] id: GO:0071031 name: nuclear mRNA surveillance of mRNA 3'-end processing namespace: biological_process def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance relationship: has_part GO:0071042 ! nuclear polyadenylation-dependent mRNA catabolic process created_by: kchris creation_date: 2009-07-28T04:29:17Z [Term] id: GO:0071032 name: nuclear mRNA surveillance of mRNP export namespace: biological_process def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] is_a: GO:0071028 ! nuclear mRNA surveillance created_by: kchris creation_date: 2009-07-28T04:31:57Z [Term] id: GO:0071033 name: nuclear retention of pre-mRNA at the site of transcription namespace: biological_process def: "The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474] is_a: GO:0008298 ! intracellular mRNA localization relationship: occurs_in GO:0005634 ! nucleus relationship: part_of GO:0071028 ! nuclear mRNA surveillance created_by: kchris creation_date: 2009-07-28T04:35:54Z [Term] id: GO:0071034 name: CUT catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:dgf, GOC:krc] synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0071043 ! CUT metabolic process created_by: kchris creation_date: 2009-07-29T12:38:04Z [Term] id: GO:0071035 name: nuclear polyadenylation-dependent rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258] synonym: "nuclear poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] is_a: GO:0016075 ! rRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process created_by: kchris creation_date: 2009-07-29T12:42:39Z [Term] id: GO:0071036 name: nuclear polyadenylation-dependent snoRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:dgf, GOC:krc, PMID:15935758] synonym: "nuclear poly(A)-dependent snoRNA catabolic process" RELATED [GOC:tb] is_a: GO:0016077 ! snoRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process relationship: has_part GO:0071050 ! snoRNA polyadenylation created_by: kchris creation_date: 2009-07-29T01:04:44Z [Term] id: GO:0071037 name: nuclear polyadenylation-dependent snRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:dgf, GOC:krc] synonym: "nuclear poly(A)-dependent snRNA catabolic process" RELATED [GOC:vw] is_a: GO:0016076 ! snRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process created_by: kchris creation_date: 2009-07-29T01:07:18Z [Term] id: GO:0071038 name: nuclear polyadenylation-dependent tRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." [GOC:dgf, GOC:krc] synonym: "nuclear poly(A)-dependent tRNA catabolic process" RELATED [GOC:vw] is_a: GO:0016078 ! tRNA catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process created_by: kchris creation_date: 2009-07-29T01:08:14Z [Term] id: GO:0071039 name: nuclear polyadenylation-dependent CUT catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258] synonym: "nuclear poly(A)-dependent CUT catabolic process" RELATED [GOC:vw] is_a: GO:0071034 ! CUT catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process created_by: kchris creation_date: 2009-07-29T01:10:34Z [Term] id: GO:0071040 name: nuclear polyadenylation-dependent antisense transcript catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:dgf, GOC:krc, PMID:18022365] synonym: "nuclear poly(A)-dependent antisense transcript catabolic process" RELATED [GOC:vw] is_a: GO:0071041 ! antisense RNA transcript catabolic process is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process created_by: kchris creation_date: 2009-07-29T01:25:21Z [Term] id: GO:0071041 name: antisense RNA transcript catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:dgf, GOC:krc] is_a: GO:0034661 ! ncRNA catabolic process is_a: GO:0042868 ! antisense RNA metabolic process created_by: kchris creation_date: 2009-07-29T01:39:36Z [Term] id: GO:0071042 name: nuclear polyadenylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474] synonym: "nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process created_by: kchris creation_date: 2009-07-29T02:06:19Z [Term] id: GO:0071043 name: CUT metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436] is_a: GO:0034660 ! ncRNA metabolic process created_by: kchris creation_date: 2009-07-29T02:31:31Z [Term] id: GO:0071044 name: histone mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0008334 ! histone mRNA metabolic process created_by: kchris creation_date: 2009-07-30T09:48:10Z [Term] id: GO:0071045 name: nuclear histone mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] is_a: GO:0071044 ! histone mRNA catabolic process created_by: kchris creation_date: 2009-07-30T09:52:44Z [Term] id: GO:0071046 name: nuclear polyadenylation-dependent ncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208] synonym: "nuclear poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process is_a: GO:0071029 ! nuclear ncRNA surveillance created_by: kchris creation_date: 2009-08-06T02:14:53Z [Term] id: GO:0071047 name: polyadenylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc] synonym: "poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] is_a: GO:0006402 ! mRNA catabolic process is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process relationship: has_part GO:0006378 ! mRNA polyadenylation created_by: kchris creation_date: 2009-08-07T09:57:56Z [Term] id: GO:0071048 name: nuclear retention of unspliced pre-mRNA at the site of transcription namespace: biological_process def: "The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:14718167] is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription relationship: part_of GO:0071030 ! nuclear mRNA surveillance of spliceosomal pre-mRNA splicing created_by: kchris creation_date: 2009-08-11T02:19:03Z [Term] id: GO:0071049 name: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription namespace: biological_process def: "The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728] is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription relationship: part_of GO:0071031 ! nuclear mRNA surveillance of mRNA 3'-end processing created_by: kchris creation_date: 2009-08-11T02:40:56Z [Term] id: GO:0071050 name: snoRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:dgf, GOC:krc, PMID:18951092] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0043629 ! ncRNA polyadenylation created_by: kchris creation_date: 2009-08-25T03:33:44Z [Term] id: GO:0071051 name: polyadenylation-dependent snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092] synonym: "poly(A)-dependent snoRNA 3'-end processing" RELATED [GOC:vw] is_a: GO:0031126 ! snoRNA 3'-end processing relationship: has_part GO:0071050 ! snoRNA polyadenylation created_by: kchris creation_date: 2009-08-25T03:47:24Z [Term] id: GO:0071052 name: alpha9-beta1 integrin-ADAM1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T03:55:15Z [Term] id: GO:0071053 name: alpha9-beta1 integrin-ADAM2 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T03:58:22Z [Term] id: GO:0071054 name: alpha9-beta1 integrin-ADAM3 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T03:59:02Z [Term] id: GO:0071055 name: alpha9-beta1 integrin-ADAM9 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T03:59:24Z [Term] id: GO:0071056 name: alpha9-beta1 integrin-ADAM15 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657] synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T03:59:49Z [Term] id: GO:0071057 name: alphav-beta3 integrin-ADAM15 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657] synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:00:14Z [Term] id: GO:0071058 name: alpha3-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516] synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:00:39Z [Term] id: GO:0071059 name: alpha6-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:01:23Z [Term] id: GO:0071060 name: alpha7-beta1 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:02:01Z [Term] id: GO:0071061 name: alpha6-beta4 integrin-CD151 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835] synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:02:37Z [Term] id: GO:0071062 name: alphav-beta3 integrin-vitronectin complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423] synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:02:57Z [Term] id: GO:0071063 name: sensory perception of wind namespace: biological_process def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637] synonym: "perception of wind" EXACT [GOC:mah] synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637] is_a: GO:0050954 ! sensory perception of mechanical stimulus created_by: midori creation_date: 2009-11-04T02:40:34Z [Term] id: GO:0071064 name: alphaE-beta7 integrin-E-cadherin complex namespace: cellular_component def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471] synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:03:37Z [Term] id: GO:0071065 name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034] synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:04:01Z [Term] id: GO:0071066 name: detection of mechanical stimulus involved in sensory perception of wind namespace: biological_process def: "The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah, PMID:19279637] synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah] synonym: "detection of wind" EXACT [GOC:mah] synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah] synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah] synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah] synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah] synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah] synonym: "sensory transduction of wind" EXACT [GOC:mah] is_a: GO:0050877 ! nervous system process is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception intersection_of: GO:0050982 ! detection of mechanical stimulus intersection_of: part_of GO:0071063 ! sensory perception of wind relationship: part_of GO:0071063 ! sensory perception of wind created_by: midori creation_date: 2009-11-04T02:47:36Z [Term] id: GO:0071067 name: alphav-beta3 integrin-ADAM23 complex namespace: cellular_component def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942] synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:04:40Z [Term] id: GO:0071068 name: alpha9-beta1 integrin-ADAM12 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520] synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:05:15Z [Term] id: GO:0071069 name: alpha4-beta1 integrin-thrombospondin-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922] synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:05:35Z [Term] id: GO:0071070 name: alpha4-beta1 integrin-thrombospondin-2 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922] synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-03T04:05:56Z [Term] id: GO:0071071 name: regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "regulation of phospholipid formation" EXACT [GOC:mah] synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008654 ! phospholipid biosynthetic process relationship: regulates GO:0008654 ! phospholipid biosynthetic process created_by: midori creation_date: 2009-11-04T03:05:11Z [Term] id: GO:0071072 name: negative regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma] synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah] synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008654 ! phospholipid biosynthetic process relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process created_by: midori creation_date: 2009-11-04T03:14:08Z [Term] id: GO:0071073 name: positive regulation of phospholipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah] synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah] synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah] synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008654 ! phospholipid biosynthetic process relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process created_by: midori creation_date: 2009-11-04T03:18:51Z [Term] id: GO:0071074 name: eukaryotic initiation factor eIF2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd] is_a: GO:0031369 ! translation initiation factor binding created_by: midori creation_date: 2009-11-06T01:39:02Z [Term] id: GO:0071075 name: CUGBP1-eIF2 complex namespace: cellular_component def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-11-06T01:43:30Z [Term] id: GO:0071076 name: RNA 3' uridylation namespace: biological_process def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462] is_a: GO:0031123 ! RNA 3'-end processing created_by: midori creation_date: 2009-11-06T02:41:23Z [Term] id: GO:0071077 name: adenosine 3',5'-bisphosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [CHEBI:37240, GOC:mah, PubChem_Compound:159296] synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem_Compound:159296] synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem_Compound:159296] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity relationship: part_of GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport created_by: midori creation_date: 2009-11-06T03:44:14Z [Term] id: GO:0071078 name: fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262] synonym: "FN-TGM2 complex" NARROW [CORUM:2375] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:42:22Z [Term] id: GO:0071079 name: alpha2-beta1 integrin-chondroadherin complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592] synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:42:55Z [Term] id: GO:0071080 name: alpha3-beta1 integrin-basigin complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995] synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:43:26Z [Term] id: GO:0071081 name: alpha3-beta1 integrin-CD63 complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079] synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:43:43Z [Term] id: GO:0071082 name: alpha9-beta1 integrin-tenascin complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552] synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:43:58Z [Term] id: GO:0071083 name: alphaV-beta3 integrin-CD47-FCER2 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797] synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:44:20Z [Term] id: GO:0071084 name: alpha2-beta1 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731] synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:44:35Z [Term] id: GO:0071085 name: alphaIIb-beta3 integrin-CD9 complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193] synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:44:52Z [Term] id: GO:0071086 name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193] synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872] is_a: GO:0090665 ! glycoprotein complex is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:45:08Z [Term] id: GO:0071087 name: alpha11-beta1 integrin-collagen type I complex namespace: cellular_component def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311] synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:45:27Z [Term] id: GO:0071088 name: alpha5-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:45:47Z [Term] id: GO:0071089 name: alphaV-beta3 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:46:02Z [Term] id: GO:0071090 name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:46:24Z [Term] id: GO:0071091 name: alpha1-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:46:44Z [Term] id: GO:0071092 name: alpha3-beta1 integrin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:47:04Z [Term] id: GO:0071093 name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:47:22Z [Term] id: GO:0071094 name: alpha6-beta4 integrin-CD9 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425] synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:47:44Z [Term] id: GO:0071095 name: alpha3-beta1 integrin-thrombospondin complex namespace: cellular_component def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957] synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:48:03Z [Term] id: GO:0071096 name: alphaV-beta3 integrin-gelsolin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104] synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:49:31Z [Term] id: GO:0071097 name: alphaV-beta3 integrin-paxillin-Pyk2 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411] synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:51:52Z [Term] id: GO:0071098 name: alpha6-beta4 integrin-Fyn complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709] synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:52:10Z [Term] id: GO:0071099 name: alphaV-beta6 integrin-TGFbeta-3 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050] synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:52:27Z [Term] id: GO:0071100 name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960] synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:52:43Z [Term] id: GO:0071101 name: alpha4-beta1 integrin-JAM2 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135] synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:52:59Z [Term] id: GO:0071102 name: alpha4-beta1 integrin-paxillin complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126] synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-06T04:53:22Z [Term] id: GO:0071103 name: DNA conformation change namespace: biological_process def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] subset: goslim_metagenomics synonym: "DNA conformation modification" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization created_by: midori creation_date: 2009-11-09T11:36:34Z [Term] id: GO:0071104 name: response to interleukin-9 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah, GOC:yaf] synonym: "response to IL-9" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-11-09T12:50:25Z [Term] id: GO:0071105 name: response to interleukin-11 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah, GOC:yaf] synonym: "response to IL-11" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine created_by: midori creation_date: 2009-11-09T12:52:51Z [Term] id: GO:0071106 name: adenosine 3',5'-bisphosphate transmembrane transport namespace: biological_process def: "The process in which adenosine 3',5'-bisphosphate is transported across a membrane." [CHEBI:37240, GOC:mah, PubChem_Compound:159296] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "adenosine 3',5'-bisphosphate membrane transport" EXACT [] synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem_Compound:159296] synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem_Compound:159296] is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: midori creation_date: 2009-11-12T10:40:49Z [Term] id: GO:0071107 name: response to parathyroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah, GOC:yaf] synonym: "response to parathyroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone created_by: midori creation_date: 2009-11-12T10:58:45Z [Term] id: GO:0071108 name: protein K48-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah] is_a: GO:0016579 ! protein deubiquitination created_by: midori creation_date: 2009-11-12T01:34:01Z [Term] id: GO:0071109 name: superior temporal gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021987 ! cerebral cortex development created_by: midori creation_date: 2009-11-12T02:19:23Z [Term] id: GO:0071110 name: histone biotinylation namespace: biological_process def: "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] is_a: GO:0009305 ! protein biotinylation is_a: GO:0016570 ! histone modification created_by: midori creation_date: 2009-11-13T01:22:59Z [Term] id: GO:0071111 name: cyclic-guanylate-specific phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)." [EC:3.1.4.52, RHEA:24902] synonym: "c-di-GMP phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "c-di-GMP-specific phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" EXACT [EC:3.1.4.52] synonym: "PDEA1" RELATED [EC:3.1.4.52] synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52] synonym: "VieA" RELATED [EC:3.1.4.52] xref: EC:3.1.4.52 xref: KEGG_REACTION:R08991 xref: MetaCyc:RXN0-4181 xref: RHEA:24902 is_a: GO:0008081 ! phosphoric diester hydrolase activity created_by: midori creation_date: 2009-11-13T02:10:39Z [Term] id: GO:0071112 name: alpha4-beta4 integrin-EMILIN-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677] synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:17:11Z [Term] id: GO:0071113 name: alphaIIb-beta3 integrin-ICAM-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717] synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:17:59Z [Term] id: GO:0071114 name: alphaV-beta3 integrin-tumstatin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293] synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:18:29Z [Term] id: GO:0071115 name: alpha5-beta1 integrin-endostatin complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293] synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:18:57Z [Term] id: GO:0071116 name: alpha6-beta1 integrin-CYR61 complex namespace: cellular_component def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661] synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:19:23Z [Term] id: GO:0071117 name: alpha5-beta1 integrin-fibronectin-NOV complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636] synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:19:52Z [Term] id: GO:0071118 name: alphaV-beta3 integrin-NOV complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636] synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:20:20Z [Term] id: GO:0071119 name: alpha7-beta1 integrin-nicotinamide riboside kinase complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630] synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:20:44Z [Term] id: GO:0071120 name: alpha4-beta1 integrin-CD47 complex namespace: cellular_component def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185] synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:21:10Z [Term] id: GO:0071121 name: alpha9-beta1 integrin-VEGF-D complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642] synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:21:37Z [Term] id: GO:0071122 name: alpha9-beta1 integrin-VEGF-A complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377] synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:22:01Z [Term] id: GO:0071123 name: alpha9-beta1 integrin-VEGF-C complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642] synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:22:27Z [Term] id: GO:0071124 name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex namespace: cellular_component def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458] synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:22:51Z [Term] id: GO:0071125 name: alphaV-beta3 integrin-EGFR complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425] synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:23:18Z [Term] id: GO:0071126 name: alphaV-beta6 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:23:43Z [Term] id: GO:0071127 name: alpha9-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:24:09Z [Term] id: GO:0071128 name: alpha5-beta1 integrin-osteopontin complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200] synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:24:43Z [Term] id: GO:0071129 name: alphaV-beta3 integrin-LPP3 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:25:17Z [Term] id: GO:0071130 name: alpha5-beta1 integrin-LPP3 complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:25:47Z [Term] id: GO:0071131 name: alphaV-beta3 integrin-laminin alpha-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487] synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:26:11Z [Term] id: GO:0071132 name: alphaX-beta2 integrin-ICAM-4 complex namespace: cellular_component def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175] synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:28:30Z [Term] id: GO:0071133 name: alpha9-beta1 integrin-ADAM8 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821] synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:28:49Z [Term] id: GO:0071134 name: alpha9-beta1 integrin-thrombospondin-1 complex namespace: cellular_component def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041] synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:29:07Z [Term] id: GO:0071135 name: alpha7-beta1 integrin-focal adhesion kinase complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176] synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:29:24Z [Term] id: GO:0071136 name: alpha7-beta1 integrin-laminin alpha-2 complex namespace: cellular_component def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176] synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:29:42Z [Term] id: GO:0071137 name: alphaV-beta3 integrin-CD98 complex namespace: cellular_component def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696] synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:29:59Z [Term] id: GO:0071138 name: alpha5-beta5-fibronectin-SFRP2 complex namespace: cellular_component def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558] synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-13T02:30:31Z [Term] id: GO:0071139 name: resolution of recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination created_by: midori creation_date: 2009-11-16T12:02:21Z [Term] id: GO:0071140 name: resolution of mitotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] is_a: GO:0071139 ! resolution of recombination intermediates relationship: part_of GO:0006312 ! mitotic recombination created_by: midori creation_date: 2009-11-16T12:06:05Z [Term] id: GO:0071141 name: SMAD protein complex namespace: cellular_component def: "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] synonym: "SMAD complex" EXACT [GOC:mah] is_a: GO:0005622 ! intracellular is_a: GO:0032991 ! protein-containing complex created_by: midori creation_date: 2009-11-16T02:28:59Z [Term] id: GO:0071142 name: homomeric SMAD protein complex namespace: cellular_component alt_id: GO:0071143 def: "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive." [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020] synonym: "SMAD1 homotrimer complex" NARROW [] synonym: "SMAD1 protein complex" NARROW [] synonym: "SMAD2 homotrimer complex" NARROW [] synonym: "SMAD2 protein complex" NARROW [] synonym: "SMAD3 homotrimer complex" NARROW [CORUM:3003] synonym: "SMAD3 protein complex" NARROW [] xref: IntAct:EBI-10043504 xref: IntAct:EBI-10043549 xref: IntAct:EBI-10043574 xref: IntAct:EBI-10043586 xref: IntAct:EBI-10828213 xref: IntAct:EBI-10828300 is_a: GO:0071141 ! SMAD protein complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-11-16T02:41:19Z [Term] id: GO:0071144 name: heteromeric SMAD protein complex namespace: cellular_component alt_id: GO:0071145 alt_id: GO:0071146 def: "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] synonym: "SMAD1-SMAD4 protein complex" NARROW [] synonym: "SMAD2-SMAD3-SMAD4 protein complex" NARROW [] synonym: "SMAD2-SMAD4 protein complex" NARROW [CORUM:3001] synonym: "SMAD3-SMAD4 protein complex" NARROW [] xref: IntAct:EBI-10021614 xref: IntAct:EBI-10043452 xref: IntAct:EBI-10127301 xref: IntAct:EBI-10828741 xref: IntAct:EBI-9692430 xref: IntAct:EBI-9826270 xref: IntAct:EBI-9826300 xref: IntAct:EBI-9990274 is_a: GO:0071141 ! SMAD protein complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex creation_date: 2009-11-16T02:44:37Z [Term] id: GO:0071147 name: TEAD-2 multiprotein complex namespace: cellular_component def: "A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others." [GOC:mah, PMID:11358867] xref: CORUM:2870 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-16T03:31:35Z [Term] id: GO:0071148 name: TEAD-1-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA binding protein TEAD-1 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-11-16T03:38:43Z [Term] id: GO:0071149 name: TEAD-2-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA binding protein TEAD-2 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-11-16T03:58:10Z [Term] id: GO:0071150 name: TEAD-3-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA binding protein TEAD-3 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-11-16T03:58:31Z [Term] id: GO:0071151 name: TEAD-4-YAP complex namespace: cellular_component def: "A transcription factor complex that is composed of the DNA binding protein TEAD-4 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2009-11-16T03:58:48Z [Term] id: GO:0071152 name: G-protein alpha(q)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-16T04:48:05Z [Term] id: GO:0071153 name: G-protein alpha(o)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172] synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-16T04:55:00Z [Term] id: GO:0071154 name: G-protein alpha(i)1-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170] synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-16T04:57:46Z [Term] id: GO:0071155 name: G-protein alpha(13)-synembrin complex namespace: cellular_component def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-16T05:01:55Z [Term] id: GO:0071156 name: regulation of cell cycle arrest namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007050 ! cell cycle arrest relationship: regulates GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2009-11-17T01:38:39Z [Term] id: GO:0071157 name: negative regulation of cell cycle arrest namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0071156 ! regulation of cell cycle arrest intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007050 ! cell cycle arrest relationship: negatively_regulates GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2009-11-17T01:42:57Z [Term] id: GO:0071158 name: positive regulation of cell cycle arrest namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases." [GOC:mah] is_a: GO:0071156 ! regulation of cell cycle arrest is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007050 ! cell cycle arrest relationship: positively_regulates GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2009-11-17T01:43:47Z [Term] id: GO:0071159 name: NF-kappaB complex namespace: cellular_component def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2009-11-17T02:03:34Z [Term] id: GO:0071160 name: cyanophycin synthetase activity (L-aspartate-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29] xref: EC:6.3.2.29 is_a: GO:0043860 ! cyanophycin synthetase activity created_by: midori creation_date: 2009-11-17T05:18:17Z [Term] id: GO:0071161 name: cyanophycin synthetase activity (L-arginine-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30] xref: EC:6.3.2.30 is_a: GO:0043860 ! cyanophycin synthetase activity created_by: midori creation_date: 2009-11-17T05:19:54Z [Term] id: GO:0071162 name: CMG complex namespace: cellular_component def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] synonym: "unwindosome" EXACT [PMID:19228417] is_a: GO:0031261 ! DNA replication preinitiation complex relationship: has_part GO:0000811 ! GINS complex relationship: part_of GO:0000228 ! nuclear chromosome created_by: midori creation_date: 2009-11-19T11:04:13Z [Term] id: GO:0071163 name: DNA replication preinitiation complex assembly namespace: biological_process alt_id: GO:1902293 alt_id: GO:1902316 def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah] synonym: "pre-IC complex assembly" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0033260 ! nuclear DNA replication created_by: midori creation_date: 2009-11-19T11:13:41Z [Term] id: GO:0071164 name: RNA trimethylguanosine synthase activity namespace: molecular_function def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [GOC:BHF, PMID:11983179, PMID:18775984] synonym: "cap hypermethylase activity" EXACT [PMID:11983179] synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl] synonym: "snRNA methyltransferase activity" RELATED [GOC:rl] is_a: GO:0008173 ! RNA methyltransferase activity relationship: part_of GO:0036261 ! 7-methylguanosine cap hypermethylation created_by: midori creation_date: 2009-11-19T03:23:20Z [Term] id: GO:0071165 name: GINS complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792] is_a: GO:0071163 ! DNA replication preinitiation complex assembly created_by: midori creation_date: 2009-11-19T03:37:20Z [Term] id: GO:0071166 name: ribonucleoprotein complex localization namespace: biological_process def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "RNP localization" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization created_by: midori creation_date: 2009-11-19T04:46:05Z [Term] id: GO:0071167 name: obsolete ribonucleoprotein complex import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah] synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl] synonym: "RNP import into nucleus" EXACT [GOC:mah] is_obsolete: true consider: GO:0006606 created_by: midori creation_date: 2009-11-19T04:48:42Z [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome created_by: midori creation_date: 2009-11-20T11:51:20Z [Term] id: GO:0071169 name: establishment of protein localization to chromatin namespace: biological_process def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome is_a: GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2009-11-20T11:52:43Z [Term] id: GO:0071170 name: site-specific DNA replication termination namespace: biological_process def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894] comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children. is_a: GO:0006274 ! DNA replication termination created_by: midori creation_date: 2009-11-20T01:07:30Z [Term] id: GO:0071171 name: site-specific DNA replication termination at RTS1 barrier namespace: biological_process def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894] is_a: GO:0071170 ! site-specific DNA replication termination relationship: part_of GO:0071516 ! establishment of imprinting at mating-type locus created_by: midori creation_date: 2009-11-20T01:24:41Z [Term] id: GO:0071172 name: dihydromonapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor created_by: midori creation_date: 2009-11-23T11:10:17Z [Term] id: GO:0071173 name: spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic). subset: gocheck_do_not_manually_annotate synonym: "SAC" BROAD [GOC:mah] is_a: GO:0031577 ! spindle checkpoint created_by: midori creation_date: 2009-11-23T12:36:57Z [Term] id: GO:0071174 name: mitotic spindle checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent). subset: gocheck_do_not_manually_annotate synonym: "mitotic cell cycle spindle checkpoint" EXACT [] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031577 ! spindle checkpoint intersection_of: GO:0031577 ! spindle checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: midori creation_date: 2009-11-23T12:41:36Z [Term] id: GO:0071175 name: MAML2-RBP-Jkappa-ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:36:28Z [Term] id: GO:0071176 name: MAML2-RBP-Jkappa-ICN2 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:42:24Z [Term] id: GO:0071177 name: MAML2-RBP-Jkappa-ICN3 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:48:56Z [Term] id: GO:0071178 name: MAML2-RBP-Jkappa-ICN4 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:49:21Z [Term] id: GO:0071179 name: MAML3-RBP-Jkappa-ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:50:39Z [Term] id: GO:0071180 name: MAML3-RBP-Jkappa-ICN2 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:51:29Z [Term] id: GO:0071181 name: MAML3-RBP-Jkappa-ICN3 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:52:05Z [Term] id: GO:0071182 name: MAML3-RBP-Jkappa-ICN4 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2009-11-23T02:52:35Z [Term] id: GO:0071183 name: protocadherin-alpha-protocadherin-gamma complex namespace: cellular_component def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] is_a: GO:0098797 ! plasma membrane protein complex created_by: midori creation_date: 2009-11-23T04:10:30Z [Term] id: GO:0071184 name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:11:47Z [Term] id: GO:0071185 name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:16:47Z [Term] id: GO:0071186 name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:21:33Z [Term] id: GO:0071187 name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:22:08Z [Term] id: GO:0071188 name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:23:25Z [Term] id: GO:0071189 name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:24:28Z [Term] id: GO:0071190 name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:30:12Z [Term] id: GO:0071191 name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex namespace: cellular_component def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020] is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex created_by: midori creation_date: 2009-11-23T04:30:51Z [Term] id: GO:0071192 name: Kv4.2-KChIP1 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:606 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T04:51:42Z [Term] id: GO:0071193 name: Kv4.2-KChIP2 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:607 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T04:58:09Z [Term] id: GO:0071194 name: Kv4.2-KChIP3 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:608 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T04:58:41Z [Term] id: GO:0071195 name: Kv4.2-KChIP4 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] xref: CORUM:3090 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T04:59:06Z [Term] id: GO:0071196 name: Kv4.3-KChIP1 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203] xref: CORUM:3091 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T04:59:38Z [Term] id: GO:0071197 name: Kv4.2-Kv4.3 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203] xref: CORUM:609 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:00:33Z [Term] id: GO:0071198 name: Kv4.1-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:600 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:14:37Z [Term] id: GO:0071199 name: Kv4.1-DPP10 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355] xref: CORUM:601 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:17:50Z [Term] id: GO:0071200 name: Kv4.2-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355] synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:603 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:18:31Z [Term] id: GO:0071201 name: Kv4.3-DPP6 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355] synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355] xref: CORUM:599 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:20:54Z [Term] id: GO:0071202 name: Kv4.3-DPP10 channel complex namespace: cellular_component def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355] synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355] xref: CORUM:598 is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: midori creation_date: 2009-11-23T05:21:37Z [Term] id: GO:0071203 name: WASH complex namespace: cellular_component def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-11-25T11:01:33Z [Term] id: GO:0071204 name: histone pre-mRNA 3'end processing complex namespace: cellular_component def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752] synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2009-11-25T11:11:02Z [Term] id: GO:0071205 name: protein localization to juxtaparanode region of axon namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] synonym: "protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0099612 ! protein localization to axon created_by: midori creation_date: 2009-11-25T01:13:55Z [Term] id: GO:0071206 name: establishment of protein localization to juxtaparanode region of axon namespace: biological_process def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071205 ! protein localization to juxtaparanode region of axon created_by: midori creation_date: 2009-11-25T01:15:23Z [Term] id: GO:0071207 name: histone pre-mRNA stem-loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752] is_a: GO:0036002 ! pre-mRNA binding created_by: midori creation_date: 2009-11-25T01:25:15Z [Term] id: GO:0071208 name: histone pre-mRNA DCP binding namespace: molecular_function def: "Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752] is_a: GO:0003723 ! RNA binding created_by: midori creation_date: 2009-11-25T01:41:35Z [Term] id: GO:0071209 name: U7 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding created_by: midori creation_date: 2009-11-25T01:46:50Z [Term] id: GO:0071210 name: protein insertion into membrane raft namespace: biological_process def: "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "establishment of protein localization to membrane raft" BROAD [GOC:mah, GOC:vw] is_a: GO:0051205 ! protein insertion into membrane is_a: GO:1903044 ! protein localization to membrane raft relationship: part_of GO:0031579 ! membrane raft organization created_by: midori creation_date: 2009-11-25T02:11:46Z [Term] id: GO:0071211 name: protein targeting to vacuole involved in autophagy namespace: biological_process def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm." [GOC:mah] synonym: "protein targeting to autophagosome" RELATED [GOC:pad] is_a: GO:0006623 ! protein targeting to vacuole intersection_of: GO:0006623 ! protein targeting to vacuole intersection_of: part_of GO:0006914 ! autophagy relationship: part_of GO:0006914 ! autophagy created_by: midori creation_date: 2009-11-25T02:25:27Z [Term] id: GO:0071212 name: subsynaptic reticulum namespace: cellular_component def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331] synonym: "SSR" EXACT [PMID:19244343] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0061174 ! type I terminal bouton created_by: midori creation_date: 2009-12-01T05:05:21Z [Term] id: GO:0071213 name: cellular response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah] is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid is_a: GO:0071230 ! cellular response to amino acid stimulus created_by: midori creation_date: 2009-12-03T12:10:11Z [Term] id: GO:0071214 name: cellular response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "cellular response to abiotic stress" NARROW [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0104004 ! cellular response to environmental stimulus created_by: midori creation_date: 2009-12-03T01:02:11Z [Term] id: GO:0071215 name: cellular response to abscisic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah] is_a: GO:0009737 ! response to abscisic acid is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2009-12-03T01:04:18Z [Term] id: GO:0071216 name: cellular response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "cellular response to biotic stress" NARROW [GOC:mah] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2009-12-03T01:09:08Z [Term] id: GO:0071217 name: cellular response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071496 ! cellular response to external stimulus created_by: midori creation_date: 2009-12-03T01:14:27Z [Term] id: GO:0071218 name: cellular response to misfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah] is_a: GO:0035967 ! cellular response to topologically incorrect protein is_a: GO:0051788 ! response to misfolded protein created_by: midori creation_date: 2009-12-03T01:17:46Z [Term] id: GO:0071219 name: cellular response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah] synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah] synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah] synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0071216 ! cellular response to biotic stimulus created_by: midori creation_date: 2009-12-03T01:22:00Z [Term] id: GO:0071220 name: cellular response to bacterial lipoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah] is_a: GO:0032493 ! response to bacterial lipoprotein is_a: GO:0071219 ! cellular response to molecule of bacterial origin created_by: midori creation_date: 2009-12-03T01:26:36Z [Term] id: GO:0071221 name: cellular response to bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah] is_a: GO:0070339 ! response to bacterial lipopeptide is_a: GO:0071220 ! cellular response to bacterial lipoprotein created_by: midori creation_date: 2009-12-03T01:28:03Z [Term] id: GO:0071222 name: cellular response to lipopolysaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah] synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl] synonym: "cellular response to LPS" EXACT [GOC:mah] is_a: GO:0032496 ! response to lipopolysaccharide is_a: GO:0071219 ! cellular response to molecule of bacterial origin is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T01:29:29Z [Term] id: GO:0071223 name: cellular response to lipoteichoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah] synonym: "cellular response to LTA" EXACT [GOC:mah] is_a: GO:0070391 ! response to lipoteichoic acid is_a: GO:0071219 ! cellular response to molecule of bacterial origin is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T01:31:00Z [Term] id: GO:0071224 name: cellular response to peptidoglycan namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah] is_a: GO:0032494 ! response to peptidoglycan is_a: GO:0071219 ! cellular response to molecule of bacterial origin is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T01:36:38Z [Term] id: GO:0071225 name: cellular response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah] is_a: GO:0032495 ! response to muramyl dipeptide is_a: GO:0035690 ! cellular response to drug is_a: GO:1901653 ! cellular response to peptide created_by: midori creation_date: 2009-12-03T01:41:23Z [Term] id: GO:0071226 name: cellular response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah] synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah] is_a: GO:0002238 ! response to molecule of fungal origin is_a: GO:0071216 ! cellular response to biotic stimulus created_by: midori creation_date: 2009-12-03T01:50:01Z [Term] id: GO:0071227 name: cellular response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah] synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah] is_a: GO:0002240 ! response to molecule of oomycetes origin is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071310 ! cellular response to organic substance relationship: part_of GO:0009620 ! response to fungus created_by: midori creation_date: 2009-12-03T01:55:09Z [Term] id: GO:0071228 name: cellular response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah] is_a: GO:0002347 ! response to tumor cell is_a: GO:0071216 ! cellular response to biotic stimulus created_by: midori creation_date: 2009-12-03T02:04:43Z [Term] id: GO:0071229 name: cellular response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "cellular response to acid" BROAD [] synonym: "cellular response to acid anion" RELATED [] synonym: "cellular response to oxoanion" RELATED [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-03T02:07:23Z [Term] id: GO:0071230 name: cellular response to amino acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:mah] synonym: "cellular response to amino acid" EXACT [GOC:mah] is_a: GO:0043200 ! response to amino acid is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:08:11Z [Term] id: GO:0071231 name: cellular response to folic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah] synonym: "response to folate" EXACT [GOC:mah] synonym: "response to vitamin B9" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0051593 ! response to folic acid is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:08:32Z [Term] id: GO:0071232 name: cellular response to histidine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0080052 ! response to histidine created_by: midori creation_date: 2009-12-03T02:09:15Z [Term] id: GO:0071233 name: cellular response to leucine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mah] is_a: GO:0043201 ! response to leucine is_a: GO:0071230 ! cellular response to amino acid stimulus created_by: midori creation_date: 2009-12-03T02:09:26Z [Term] id: GO:0071234 name: cellular response to phenylalanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0080053 ! response to phenylalanine created_by: midori creation_date: 2009-12-03T02:09:36Z [Term] id: GO:0071235 name: cellular response to proline namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah] is_a: GO:0010238 ! response to proline is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-03T02:09:45Z [Term] id: GO:0071236 name: cellular response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah] is_a: GO:0046677 ! response to antibiotic is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-03T02:23:49Z [Term] id: GO:0071237 name: cellular response to bacteriocin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah] is_a: GO:0046678 ! response to bacteriocin is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1901653 ! cellular response to peptide created_by: midori creation_date: 2009-12-03T02:25:43Z [Term] id: GO:0071238 name: cellular response to brefeldin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] is_a: GO:0031001 ! response to brefeldin A is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:25:52Z [Term] id: GO:0071239 name: cellular response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0046679 ! response to streptomycin is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:25:59Z [Term] id: GO:0071240 name: cellular response to food namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah] is_a: GO:0032094 ! response to food is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-03T02:28:35Z [Term] id: GO:0071241 name: cellular response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah] is_a: GO:0010035 ! response to inorganic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-03T02:35:49Z [Term] id: GO:0071242 name: cellular response to ammonium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah] is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901699 ! cellular response to nitrogen compound created_by: midori creation_date: 2009-12-03T02:39:40Z [Term] id: GO:0071243 name: cellular response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah] synonym: "cellular response to arsenic" EXACT [] is_a: GO:0046685 ! response to arsenic-containing substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-03T02:41:05Z [Term] id: GO:0071244 name: cellular response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah] is_a: GO:0010037 ! response to carbon dioxide is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:41:21Z [Term] id: GO:0071245 name: cellular response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah] is_a: GO:0034465 ! response to carbon monoxide is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:44:43Z [Term] id: GO:0071246 name: cellular response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah] is_a: GO:0010157 ! response to chlorate is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:45:36Z [Term] id: GO:0071247 name: cellular response to chromate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah] is_a: GO:0046687 ! response to chromate is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T02:46:01Z [Term] id: GO:0071248 name: cellular response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] synonym: "cellular response to heavy metal" NARROW [GOC:mah] synonym: "cellular response to metal" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion is_a: GO:0071241 ! cellular response to inorganic substance created_by: midori creation_date: 2009-12-03T02:46:31Z [Term] id: GO:0071249 name: cellular response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah] is_a: GO:0010167 ! response to nitrate is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902170 ! cellular response to reactive nitrogen species created_by: midori creation_date: 2009-12-03T03:02:06Z [Term] id: GO:0071250 name: cellular response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:mah] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0080033 ! response to nitrite is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902170 ! cellular response to reactive nitrogen species created_by: midori creation_date: 2009-12-03T03:03:49Z [Term] id: GO:0071251 name: cellular response to silicon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah] synonym: "cellular response to silica" EXACT [GOC:mah] synonym: "cellular response to silox" EXACT [GOC:mah] is_a: GO:0034021 ! response to silicon dioxide is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T03:09:41Z [Term] id: GO:0071252 name: cellular response to sulfur dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah] is_a: GO:0010477 ! response to sulfur dioxide is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-03T03:10:16Z [Term] id: GO:0071253 name: connexin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490] is_a: GO:0005515 ! protein binding created_by: midori creation_date: 2009-12-04T10:07:54Z [Term] id: GO:0071254 name: cytoplasmic U snRNP body namespace: cellular_component def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] synonym: "U body" EXACT [GOC:sart, PMID:17595295] synonym: "U-body" EXACT [GOC:mah] is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2009-12-04T10:31:29Z [Term] id: GO:0071255 name: Cvt vesicle assembly namespace: biological_process def: "A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977] synonym: "Cvt vesicle biosynthesis" RELATED [GOC:mah] synonym: "Cvt vesicle formation" EXACT [GOC:mah] synonym: "cytoplasm to vacuole targeting vesicle assembly" EXACT [] synonym: "cytoplasm-to-vacuole targetin vesicle assembly" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0032258 ! cytoplasm to vacuole transport by the Cvt pathway created_by: midori creation_date: 2009-12-04T10:39:50Z [Term] id: GO:0071256 name: translocon complex namespace: cellular_component alt_id: GO:0031206 def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571] subset: goslim_pir synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane created_by: midori creation_date: 2009-12-08T02:08:03Z [Term] id: GO:0071257 name: cellular response to electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah] synonym: "cellular response to electricity" RELATED [GOC:mah] is_a: GO:0051602 ! response to electrical stimulus is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-04T03:27:03Z [Term] id: GO:0071258 name: cellular response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah] synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah] is_a: GO:0009629 ! response to gravity is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-04T03:31:36Z [Term] id: GO:0071259 name: cellular response to magnetism namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah] synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah] is_a: GO:0071000 ! response to magnetism is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-04T03:54:53Z [Term] id: GO:0071260 name: cellular response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah] synonym: "cellular mechanical stimulus response" EXACT [GOC:mah] is_a: GO:0009612 ! response to mechanical stimulus is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0071496 ! cellular response to external stimulus created_by: midori creation_date: 2009-12-04T03:55:44Z [Term] id: GO:0071261 name: Ssh1 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571] synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex created_by: midori creation_date: 2009-12-08T02:22:55Z [Term] id: GO:0071262 name: regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043558 ! regulation of translational initiation in response to stress created_by: midori creation_date: 2009-12-08T05:31:05Z [Term] id: GO:0071263 name: negative regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0071262 ! regulation of translational initiation in response to starvation created_by: midori creation_date: 2009-12-08T05:33:12Z [Term] id: GO:0071264 name: positive regulation of translational initiation in response to starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah] synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah] synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah] synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0071262 ! regulation of translational initiation in response to starvation created_by: midori creation_date: 2009-12-08T05:35:45Z [Term] id: GO:0071265 name: L-methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [CHEBI:16643, GOC:ecd] synonym: "L-methionine anabolism" EXACT [GOC:mah] synonym: "L-methionine biosynthesis" EXACT [GOC:mah] synonym: "L-methionine formation" EXACT [GOC:mah] synonym: "L-methionine synthesis" EXACT [GOC:mah] is_a: GO:0009086 ! methionine biosynthetic process is_a: GO:0017144 ! drug metabolic process created_by: midori creation_date: 2009-12-09T04:28:15Z [Term] id: GO:0071266 name: 'de novo' L-methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [CHEBI:16643, GOC:ecd] synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah] synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah] synonym: "'de novo' L-methionine formation" EXACT [GOC:mah] synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah] is_a: GO:0071265 ! L-methionine biosynthetic process created_by: midori creation_date: 2009-12-09T04:34:41Z [Term] id: GO:0071267 name: L-methionine salvage namespace: biological_process def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [CHEBI:16643, GOC:ecd] is_a: GO:0043102 ! amino acid salvage is_a: GO:0071265 ! L-methionine biosynthetic process created_by: midori creation_date: 2009-12-09T04:36:49Z [Term] id: GO:0071268 name: homocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [CHEBI:17230, GOC:ecd, GOC:mah] synonym: "homocysteine anabolism" EXACT [GOC:mah] synonym: "homocysteine biosynthesis" EXACT [GOC:mah] synonym: "homocysteine formation" EXACT [GOC:mah] synonym: "homocysteine synthesis" EXACT [GOC:mah] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0050667 ! homocysteine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process created_by: midori creation_date: 2009-12-09T05:32:48Z [Term] id: GO:0071269 name: L-homocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [CHEBI:17588, GOC:ecd, GOC:mah] synonym: "L-homocysteine anabolism" EXACT [GOC:mah] synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah] synonym: "L-homocysteine formation" EXACT [GOC:mah] synonym: "L-homocysteine synthesis" EXACT [GOC:mah] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0071268 ! homocysteine biosynthetic process created_by: midori creation_date: 2009-12-09T05:36:37Z [Term] id: GO:0071270 name: 1-butanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah] synonym: "1-butanol metabolism" EXACT [GOC:mah] synonym: "butan-1-ol metabolic process" EXACT [CHEBI:28885] synonym: "butanol metabolic process" BROAD [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process created_by: midori creation_date: 2009-12-10T10:23:11Z [Term] id: GO:0071271 name: 1-butanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [CHEBI:28885, GOC:ecd, GOC:mah] synonym: "1-butanol anabolism" EXACT [GOC:mah] synonym: "1-butanol biosynthesis" EXACT [GOC:mah] synonym: "1-butanol formation" EXACT [GOC:mah] synonym: "1-butanol synthesis" EXACT [GOC:mah] synonym: "butan-1-ol biosynthetic process" EXACT [CHEBI:28885] synonym: "butanol biosynthetic process" BROAD [GOC:mah] is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0071270 ! 1-butanol metabolic process created_by: midori creation_date: 2009-12-10T10:27:24Z [Term] id: GO:0071272 name: morphine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:mah] synonym: "morphine metabolism" EXACT [GOC:mah] xref: Wikipedia:Morphine is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: midori creation_date: 2009-12-10T11:11:51Z [Term] id: GO:0071273 name: morphine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:ecd, GOC:mah] synonym: "morphine breakdown" EXACT [GOC:mah] synonym: "morphine catabolism" EXACT [GOC:mah] synonym: "morphine degradation" EXACT [GOC:mah] xref: UniPathway:Q02198 is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0071272 ! morphine metabolic process is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process created_by: midori creation_date: 2009-12-10T11:16:28Z [Term] id: GO:0071274 name: isoquinoline alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah] synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah] synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah] synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: midori creation_date: 2009-12-10T11:17:49Z [Term] id: GO:0071275 name: cellular response to aluminum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah] synonym: "cellular response to aluminium ion" EXACT [GOC:mah] synonym: "cellular response to aluminum" EXACT [GOC:mah] is_a: GO:0010044 ! response to aluminum ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:52:20Z [Term] id: GO:0071276 name: cellular response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah] synonym: "cellular response to cadmium" EXACT [GOC:mah] is_a: GO:0046686 ! response to cadmium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:54:49Z [Term] id: GO:0071277 name: cellular response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] is_a: GO:0051592 ! response to calcium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:55:01Z [Term] id: GO:0071278 name: cellular response to cesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah] synonym: "cellular response to cesium" EXACT [GOC:mah] is_a: GO:0010164 ! response to cesium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:55:44Z [Term] id: GO:0071279 name: cellular response to cobalt ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] is_a: GO:0032025 ! response to cobalt ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:55:55Z [Term] id: GO:0071280 name: cellular response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah] synonym: "cellular response to copper" EXACT [GOC:mah] is_a: GO:0046688 ! response to copper ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:57:03Z [Term] id: GO:0071281 name: cellular response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah] synonym: "cellular response to iron" EXACT [GOC:mah] is_a: GO:0010039 ! response to iron ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T03:57:22Z [Term] id: GO:0071282 name: cellular response to iron(II) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah] synonym: "cellular response to iron(II)" EXACT [GOC:mah] is_a: GO:0010040 ! response to iron(II) ion is_a: GO:0071281 ! cellular response to iron ion created_by: midori creation_date: 2009-12-10T03:57:49Z [Term] id: GO:0071283 name: cellular response to iron(III) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah] synonym: "cellular response to iron(III)" EXACT [GOC:mah] is_a: GO:0010041 ! response to iron(III) ion is_a: GO:0071281 ! cellular response to iron ion created_by: midori creation_date: 2009-12-10T03:58:00Z [Term] id: GO:0071284 name: cellular response to lead ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah] is_a: GO:0010288 ! response to lead ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:00:41Z [Term] id: GO:0071285 name: cellular response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah] is_a: GO:0010226 ! response to lithium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:04:13Z [Term] id: GO:0071286 name: cellular response to magnesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] is_a: GO:0032026 ! response to magnesium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:05:50Z [Term] id: GO:0071287 name: cellular response to manganese ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah] synonym: "cellular response to manganese" EXACT [GOC:mah] is_a: GO:0010042 ! response to manganese ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:06:18Z [Term] id: GO:0071288 name: cellular response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah] synonym: "cellular response to mercuric ion" EXACT [GOC:mah] synonym: "cellular response to mercury" EXACT [GOC:mah] is_a: GO:0046689 ! response to mercury ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:06:37Z [Term] id: GO:0071289 name: cellular response to nickel ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah] synonym: "cellular response to nickel" EXACT [GOC:mah] is_a: GO:0010045 ! response to nickel cation is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:07:31Z [Term] id: GO:0071290 name: cellular response to platinum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah] synonym: "cellular response to platinum" EXACT [GOC:mah] is_a: GO:0070541 ! response to platinum ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:08:06Z [Term] id: GO:0071291 name: cellular response to selenium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah] is_a: GO:0010269 ! response to selenium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:15:52Z [Term] id: GO:0071292 name: cellular response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah] is_a: GO:0010272 ! response to silver ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:16:30Z [Term] id: GO:0071293 name: cellular response to tellurium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah] synonym: "cellular response to tellurium" EXACT [GOC:mah] is_a: GO:0046690 ! response to tellurium ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:16:52Z [Term] id: GO:0071294 name: cellular response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah] synonym: "cellular response to zinc" EXACT [GOC:mah] is_a: GO:0010043 ! response to zinc ion is_a: GO:0071248 ! cellular response to metal ion created_by: midori creation_date: 2009-12-10T04:17:10Z [Term] id: GO:0071295 name: cellular response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0033273 ! response to vitamin created_by: midori creation_date: 2009-12-10T04:27:24Z [Term] id: GO:0071296 name: cellular response to biotin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah] synonym: "cellular response to Bios IIB" EXACT [GOC:sl] synonym: "cellular response to coenzyme R" EXACT [GOC:sl] synonym: "cellular response to vitamin B7" EXACT [GOC:sl] synonym: "cellular response to vitamin H" EXACT [GOC:sl] is_a: GO:0035690 ! cellular response to drug is_a: GO:0070781 ! response to biotin is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:28:22Z [Term] id: GO:0071297 name: cellular response to cobalamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah] synonym: "cellular response to vitamin B12" EXACT [GOC:mah] is_a: GO:0033590 ! response to cobalamin is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-10T04:28:45Z [Term] id: GO:0071298 name: cellular response to L-ascorbic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah] synonym: "cellular response to ascorbic acid" BROAD [GOC:mah] synonym: "cellular response to L-ascorbate" EXACT [GOC:mah] synonym: "cellular response to vitamin C" EXACT [GOC:mah] is_a: GO:0033591 ! response to L-ascorbic acid is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071326 ! cellular response to monosaccharide stimulus created_by: midori creation_date: 2009-12-10T04:29:19Z [Term] id: GO:0071299 name: cellular response to vitamin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah] synonym: "cellular response to retinol" NARROW [GOC:mah] is_a: GO:0033189 ! response to vitamin A is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071396 ! cellular response to lipid created_by: midori creation_date: 2009-12-10T04:29:30Z [Term] id: GO:0071300 name: cellular response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah] synonym: "cellular response to vitamin A acid" EXACT [GOC:mah] is_a: GO:0032526 ! response to retinoic acid is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:30:34Z [Term] id: GO:0071301 name: cellular response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah] synonym: "cellular response to thiamin" EXACT [GOC:mah] synonym: "cellular response to thiamine" EXACT [GOC:mah] is_a: GO:0010266 ! response to vitamin B1 is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-10T04:32:09Z [Term] id: GO:0071302 name: cellular response to vitamin B2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah] synonym: "cellular response to riboflavin" EXACT [GOC:mah] is_a: GO:0033274 ! response to vitamin B2 is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-10T04:34:52Z [Term] id: GO:0071303 name: cellular response to vitamin B3 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah] synonym: "cellular response to niacin" NARROW [GOC:mah] synonym: "cellular response to nicotinamide" NARROW [GOC:mah] is_a: GO:0033552 ! response to vitamin B3 is_a: GO:0071295 ! cellular response to vitamin created_by: midori creation_date: 2009-12-10T04:35:04Z [Term] id: GO:0071304 name: cellular response to vitamin B6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] is_a: GO:0034516 ! response to vitamin B6 is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-10T04:35:23Z [Term] id: GO:0071305 name: cellular response to vitamin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah] synonym: "cellular response to calciferol" EXACT [GOC:mah] synonym: "cellular response to cholecalciferol" NARROW [GOC:mah] synonym: "cellular response to ergocalciferol" NARROW [GOC:mah] is_a: GO:0033280 ! response to vitamin D is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:35:37Z [Term] id: GO:0071306 name: cellular response to vitamin E namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah] synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah] synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah] synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah] is_a: GO:0033197 ! response to vitamin E is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:35:58Z [Term] id: GO:0071307 name: cellular response to vitamin K namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah] is_a: GO:0032571 ! response to vitamin K is_a: GO:0071295 ! cellular response to vitamin created_by: midori creation_date: 2009-12-10T04:36:09Z [Term] id: GO:0071308 name: cellular response to menaquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah] synonym: "cellular response to menatetrenone" EXACT [GOC:mah] synonym: "cellular response to vitamin K2" EXACT [GOC:mah] is_a: GO:0032572 ! response to menaquinone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-10T04:37:08Z [Term] id: GO:0071309 name: cellular response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah] synonym: "cellular response to vitamin K1" EXACT [GOC:mah] is_a: GO:0032573 ! response to phylloquinone is_a: GO:0071295 ! cellular response to vitamin is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-10T04:37:18Z [Term] id: GO:0071310 name: cellular response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-10T04:46:04Z [Term] id: GO:0071311 name: cellular response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah] is_a: GO:0010034 ! response to acetate is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:48:16Z [Term] id: GO:0071312 name: cellular response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah] is_a: GO:0043279 ! response to alkaloid is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-10T04:50:58Z [Term] id: GO:0071313 name: cellular response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah] is_a: GO:0031000 ! response to caffeine is_a: GO:0035690 ! cellular response to drug is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071415 ! cellular response to purine-containing compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: midori creation_date: 2009-12-10T04:52:51Z [Term] id: GO:0071314 name: cellular response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0042220 ! response to cocaine is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T04:53:20Z [Term] id: GO:0071315 name: cellular response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0043278 ! response to morphine is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071317 ! cellular response to isoquinoline alkaloid is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: midori creation_date: 2009-12-10T04:53:46Z [Term] id: GO:0071316 name: cellular response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah] is_a: GO:0035094 ! response to nicotine is_a: GO:0035690 ! cellular response to drug is_a: GO:0097237 ! cellular response to toxic substance created_by: midori creation_date: 2009-12-10T05:05:05Z [Term] id: GO:0071317 name: cellular response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah] is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-10T05:06:08Z [Term] id: GO:0071318 name: cellular response to ATP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah] synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah] synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0033198 ! response to ATP is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:09:47Z [Term] id: GO:0071319 name: cellular response to benzoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0080021 ! response to benzoic acid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:10:20Z [Term] id: GO:0071320 name: cellular response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah] synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah] synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah] synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah] synonym: "cellular response to cyclic AMP" EXACT [GOC:mah] is_a: GO:0051591 ! response to cAMP is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:12:15Z [Term] id: GO:0071321 name: cellular response to cGMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah] synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah] synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah] synonym: "cellular response to cyclic GMP" EXACT [GOC:mah] synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] is_a: GO:0070305 ! response to cGMP is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:12:58Z [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:13:33Z [Term] id: GO:0071323 name: cellular response to chitin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah] is_a: GO:0010200 ! response to chitin is_a: GO:0035690 ! cellular response to drug is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-10T05:25:54Z [Term] id: GO:0071324 name: cellular response to disaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah] is_a: GO:0034285 ! response to disaccharide is_a: GO:0071322 ! cellular response to carbohydrate stimulus created_by: midori creation_date: 2009-12-10T05:26:14Z [Term] id: GO:0071325 name: cellular response to mannitol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [GOC:mah] is_a: GO:0010555 ! response to mannitol is_a: GO:0071322 ! cellular response to carbohydrate stimulus created_by: midori creation_date: 2009-12-10T05:27:00Z [Term] id: GO:0071326 name: cellular response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0034284 ! response to monosaccharide is_a: GO:0071322 ! cellular response to carbohydrate stimulus created_by: midori creation_date: 2009-12-10T05:27:18Z [Term] id: GO:0071327 name: cellular response to trehalose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah] is_a: GO:0010353 ! response to trehalose is_a: GO:0071324 ! cellular response to disaccharide stimulus created_by: midori creation_date: 2009-12-10T05:27:54Z [Term] id: GO:0071328 name: cellular response to maltose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah] is_a: GO:0034286 ! response to maltose is_a: GO:0071324 ! cellular response to disaccharide stimulus created_by: midori creation_date: 2009-12-10T05:30:45Z [Term] id: GO:0071329 name: cellular response to sucrose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah] is_a: GO:0009744 ! response to sucrose is_a: GO:0071324 ! cellular response to disaccharide stimulus created_by: midori creation_date: 2009-12-10T05:31:22Z [Term] id: GO:0071330 name: cellular response to trehalose-6-phosphate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah] is_a: GO:0071324 ! cellular response to disaccharide stimulus is_a: GO:0080094 ! response to trehalose-6-phosphate created_by: midori creation_date: 2009-12-10T05:32:52Z [Term] id: GO:0071331 name: cellular response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] is_a: GO:0009746 ! response to hexose is_a: GO:0071326 ! cellular response to monosaccharide stimulus created_by: midori creation_date: 2009-12-10T05:37:00Z [Term] id: GO:0071332 name: cellular response to fructose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah] is_a: GO:0009750 ! response to fructose is_a: GO:0071331 ! cellular response to hexose stimulus created_by: midori creation_date: 2009-12-10T05:37:39Z [Term] id: GO:0071333 name: cellular response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] is_a: GO:0001678 ! cellular glucose homeostasis is_a: GO:0009749 ! response to glucose is_a: GO:0071331 ! cellular response to hexose stimulus created_by: midori creation_date: 2009-12-10T05:38:03Z [Term] id: GO:0071334 name: cellular response to rhamnose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah] synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah] is_a: GO:0032149 ! response to rhamnose is_a: GO:0071331 ! cellular response to hexose stimulus created_by: midori creation_date: 2009-12-10T05:38:38Z [Term] id: GO:0071335 name: hair follicle cell proliferation namespace: biological_process def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254] is_a: GO:0008283 ! cell population proliferation created_by: midori creation_date: 2009-12-11T10:49:53Z [Term] id: GO:0071336 name: regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071335 ! hair follicle cell proliferation relationship: regulates GO:0071335 ! hair follicle cell proliferation created_by: midori creation_date: 2009-12-11T10:53:40Z [Term] id: GO:0071337 name: negative regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah] synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "downregulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0071336 ! regulation of hair follicle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071335 ! hair follicle cell proliferation relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation created_by: midori creation_date: 2009-12-11T10:59:20Z [Term] id: GO:0071338 name: positive regulation of hair follicle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah] synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah] synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah] synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah] synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0071336 ! regulation of hair follicle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071335 ! hair follicle cell proliferation relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation created_by: midori creation_date: 2009-12-11T11:00:57Z [Term] id: GO:0071339 name: MLL1 complex namespace: cellular_component def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975] is_a: GO:0044665 ! MLL1/2 complex created_by: midori creation_date: 2009-12-11T11:11:36Z [Term] id: GO:0071340 name: skeletal muscle acetylcholine-gated channel clustering namespace: biological_process def: "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:bf, GOC:dsf, PMID:19285469] synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah] synonym: "skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:bf] is_a: GO:0043113 ! receptor clustering relationship: part_of GO:0001941 ! postsynaptic membrane organization relationship: part_of GO:0007528 ! neuromuscular junction development created_by: midori creation_date: 2009-12-11T11:13:55Z [Term] id: GO:0071341 name: medial cortical node namespace: cellular_component def: "A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363] synonym: "mid1p medial cortical dot" EXACT [GOC:vw] synonym: "midsome" EXACT [GOC:vw, PMID:19959363] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031097 ! medial cortex created_by: midori creation_date: 2009-12-11T11:40:36Z [Term] id: GO:0071342 name: regulation of establishment of actomyosin contractile ring localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1901648 ! regulation of actomyosin contractile ring localization is_a: GO:2000073 ! regulation of cytokinesis, site selection intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032188 ! establishment of actomyosin contractile ring localization relationship: regulates GO:0032188 ! establishment of actomyosin contractile ring localization created_by: midori creation_date: 2009-12-11T01:22:11Z [Term] id: GO:0071343 name: obsolete negative regulation of establishment of actomyosin contractile ring localization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location." [GOC:mah] comment: This term was made obsolete because it does not describe a wild-type or normal process. synonym: "negative regulation of establishment of actomyosin contractile ring localization" EXACT [] synonym: "negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_obsolete: true created_by: midori creation_date: 2009-12-11T01:33:14Z [Term] id: GO:0071344 name: diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [CHEBI:35782, GOC:pde] synonym: "pyrophosphate metabolism" EXACT [GOC:mah] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0043436 ! oxoacid metabolic process created_by: midori creation_date: 2009-12-11T01:43:41Z [Term] id: GO:0071345 name: cellular response to cytokine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] is_a: GO:0034097 ! response to cytokine is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-11T02:41:12Z [Term] id: GO:0071346 name: cellular response to interferon-gamma namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah, PR:000000017] synonym: "cellular response to gamma-interferon" RELATED [GOC:mah] synonym: "cellular response to immune interferon" EXACT [GOC:mah] synonym: "cellular response to type II IFN" BROAD [GOC:mah] synonym: "cellular response to type II interferon" BROAD [GOC:mah] is_a: GO:0034341 ! response to interferon-gamma is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:48:00Z [Term] id: GO:0071347 name: cellular response to interleukin-1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah] synonym: "cellular response to IL-1" EXACT [GOC:mah] is_a: GO:0070555 ! response to interleukin-1 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:49:17Z [Term] id: GO:0071348 name: cellular response to interleukin-11 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah] synonym: "cellular response to IL-11" EXACT [GOC:mah] is_a: GO:0071105 ! response to interleukin-11 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:49:29Z [Term] id: GO:0071349 name: cellular response to interleukin-12 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] synonym: "cellular response to IL-12" EXACT [GOC:mah] is_a: GO:0070671 ! response to interleukin-12 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:49:40Z [Term] id: GO:0071350 name: cellular response to interleukin-15 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] synonym: "cellular response to IL-15" EXACT [GOC:mah] is_a: GO:0070672 ! response to interleukin-15 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:49:51Z [Term] id: GO:0071351 name: cellular response to interleukin-18 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] synonym: "cellular response to IL-18" EXACT [GOC:mah] is_a: GO:0070673 ! response to interleukin-18 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:50:03Z [Term] id: GO:0071352 name: cellular response to interleukin-2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] synonym: "cellular response to IL-2" EXACT [GOC:mah] is_a: GO:0070669 ! response to interleukin-2 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:50:48Z [Term] id: GO:0071353 name: cellular response to interleukin-4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] synonym: "cellular response to IL-4" EXACT [GOC:mah] is_a: GO:0070670 ! response to interleukin-4 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:51:00Z [Term] id: GO:0071354 name: cellular response to interleukin-6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] synonym: "cellular response to IL-6" EXACT [GOC:mah] is_a: GO:0070741 ! response to interleukin-6 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:51:14Z [Term] id: GO:0071355 name: cellular response to interleukin-9 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah] synonym: "cellular response to IL-9" EXACT [GOC:mah] is_a: GO:0071104 ! response to interleukin-9 is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:51:26Z [Term] id: GO:0071356 name: cellular response to tumor necrosis factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] synonym: "cellular response to TNF" EXACT [GOC:mah] is_a: GO:0034612 ! response to tumor necrosis factor is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:51:37Z [Term] id: GO:0071357 name: cellular response to type I interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah, PR:000025848] synonym: "cellular response to type I IFN" EXACT [GOC:mah] is_a: GO:0034340 ! response to type I interferon is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:51:47Z [Term] id: GO:0071358 name: cellular response to type III interferon namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:mah] synonym: "cellular response to interferon-lambda" NARROW [GOC:mah] synonym: "cellular response to type III IFN" EXACT [GOC:mah] is_a: GO:0034342 ! response to type III interferon is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: midori creation_date: 2009-12-11T02:52:00Z [Term] id: GO:0071359 name: cellular response to dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah] synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah] is_a: GO:0043331 ! response to dsRNA is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901699 ! cellular response to nitrogen compound created_by: midori creation_date: 2009-12-11T03:00:32Z [Term] id: GO:0071360 name: cellular response to exogenous dsRNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah] synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah] synonym: "cellular response to viral dsRNA" NARROW [GOC:mah] is_a: GO:0043330 ! response to exogenous dsRNA is_a: GO:0071359 ! cellular response to dsRNA created_by: midori creation_date: 2009-12-11T03:02:00Z [Term] id: GO:0071361 name: cellular response to ethanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0045471 ! response to ethanol is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2009-12-11T03:02:59Z [Term] id: GO:0071362 name: cellular response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah] is_a: GO:0045472 ! response to ether is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T03:03:22Z [Term] id: GO:0071363 name: cellular response to growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] is_a: GO:0070848 ! response to growth factor is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-11T03:05:07Z [Term] id: GO:0071364 name: cellular response to epidermal growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah] synonym: "cellular response to EGF stimulus" EXACT [GOC:mah] is_a: GO:0070849 ! response to epidermal growth factor is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus created_by: midori creation_date: 2009-12-11T03:05:34Z [Term] id: GO:0071365 name: cellular response to auxin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah] is_a: GO:0009733 ! response to auxin is_a: GO:0032870 ! cellular response to hormone stimulus created_by: midori creation_date: 2009-12-11T03:10:22Z [Term] id: GO:0071366 name: cellular response to indolebutyric acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah] synonym: "cellular response to IBA stimulus" EXACT [GOC:mah] synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071365 ! cellular response to auxin stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0080026 ! response to indolebutyric acid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T03:12:14Z [Term] id: GO:0071367 name: cellular response to brassinosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah] is_a: GO:0009741 ! response to brassinosteroid is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T03:13:33Z [Term] id: GO:0071368 name: cellular response to cytokinin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah] is_a: GO:0009735 ! response to cytokinin is_a: GO:0032870 ! cellular response to hormone stimulus created_by: midori creation_date: 2009-12-11T03:13:47Z [Term] id: GO:0071369 name: cellular response to ethylene stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah] synonym: "cellular response to ethene stimulus" EXACT [GOC:mah] is_a: GO:0009723 ! response to ethylene is_a: GO:0032870 ! cellular response to hormone stimulus created_by: midori creation_date: 2009-12-11T03:13:57Z [Term] id: GO:0071370 name: cellular response to gibberellin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah] synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah] is_a: GO:0009739 ! response to gibberellin is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T03:14:21Z [Term] id: GO:0071371 name: cellular response to gonadotropin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah] synonym: "cellular response to gonadotrophin stimulus" EXACT [GOC:dph] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0034698 ! response to gonadotropin created_by: midori creation_date: 2009-12-11T03:14:35Z [Term] id: GO:0071372 name: cellular response to follicle-stimulating hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] synonym: "cellular response to follicle stimulating hormone stimulus" EXACT [] synonym: "cellular response to FSH stimulus" EXACT [] is_a: GO:0032354 ! response to follicle-stimulating hormone is_a: GO:0071371 ! cellular response to gonadotropin stimulus created_by: midori creation_date: 2009-12-11T03:15:56Z [Term] id: GO:0071373 name: cellular response to luteinizing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah] is_a: GO:0034699 ! response to luteinizing hormone is_a: GO:0071371 ! cellular response to gonadotropin stimulus is_a: GO:0071375 ! cellular response to peptide hormone stimulus created_by: midori creation_date: 2009-12-11T03:16:02Z [Term] id: GO:0071374 name: cellular response to parathyroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071107 ! response to parathyroid hormone created_by: midori creation_date: 2009-12-11T03:19:29Z [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901653 ! cellular response to peptide created_by: midori creation_date: 2009-12-11T03:24:18Z [Term] id: GO:0071376 name: cellular response to corticotropin-releasing hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah] synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah] synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah] synonym: "cellular response to CRF stimulus" EXACT [GOC:mah] synonym: "cellular response to CRH stimulus" EXACT [GOC:mah] is_a: GO:0043435 ! response to corticotropin-releasing hormone is_a: GO:0071375 ! cellular response to peptide hormone stimulus created_by: midori creation_date: 2009-12-11T03:24:56Z [Term] id: GO:0071377 name: cellular response to glucagon stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah] is_a: GO:0033762 ! response to glucagon is_a: GO:0071375 ! cellular response to peptide hormone stimulus created_by: midori creation_date: 2009-12-11T03:25:07Z [Term] id: GO:0071378 name: cellular response to growth hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah] is_a: GO:0060416 ! response to growth hormone is_a: GO:0071375 ! cellular response to peptide hormone stimulus created_by: midori creation_date: 2009-12-11T03:25:17Z [Term] id: GO:0071379 name: cellular response to prostaglandin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0034694 ! response to prostaglandin is_a: GO:0071398 ! cellular response to fatty acid created_by: midori creation_date: 2009-12-11T03:33:52Z [Term] id: GO:0071380 name: cellular response to prostaglandin E stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah] is_a: GO:0034695 ! response to prostaglandin E is_a: GO:0071379 ! cellular response to prostaglandin stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T03:34:43Z [Term] id: GO:0071381 name: cellular response to prostaglandin F stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah] is_a: GO:0034696 ! response to prostaglandin F is_a: GO:0071379 ! cellular response to prostaglandin stimulus created_by: midori creation_date: 2009-12-11T03:34:57Z [Term] id: GO:0071382 name: cellular response to prostaglandin I stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah] is_a: GO:0034697 ! response to prostaglandin I is_a: GO:0071379 ! cellular response to prostaglandin stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-11T03:45:10Z [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-11T03:49:02Z [Term] id: GO:0071384 name: cellular response to corticosteroid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah] is_a: GO:0031960 ! response to corticosteroid is_a: GO:0071383 ! cellular response to steroid hormone stimulus created_by: midori creation_date: 2009-12-11T03:52:07Z [Term] id: GO:0071385 name: cellular response to glucocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah] is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0071384 ! cellular response to corticosteroid stimulus created_by: midori creation_date: 2009-12-11T03:53:56Z [Term] id: GO:0071386 name: cellular response to corticosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah] is_a: GO:0051412 ! response to corticosterone is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T03:57:44Z [Term] id: GO:0071387 name: cellular response to cortisol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah] synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0051414 ! response to cortisol is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T03:57:55Z [Term] id: GO:0071388 name: cellular response to cortisone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah] is_a: GO:0051413 ! response to cortisone is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T03:57:59Z [Term] id: GO:0071389 name: cellular response to mineralocorticoid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah] is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0071384 ! cellular response to corticosteroid stimulus created_by: midori creation_date: 2009-12-11T03:59:02Z [Term] id: GO:0071390 name: cellular response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035075 ! response to ecdysone is_a: GO:0036315 ! cellular response to sterol is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T04:03:57Z [Term] id: GO:0071391 name: cellular response to estrogen stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah] synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah] is_a: GO:0043627 ! response to estrogen is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-11T04:09:56Z [Term] id: GO:0071392 name: cellular response to estradiol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah] synonym: "cellular response to E2 stimulus" EXACT [GOC:mah] is_a: GO:0032355 ! response to estradiol is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T04:10:31Z [Term] id: GO:0071393 name: cellular response to progesterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah] is_a: GO:0032570 ! response to progesterone is_a: GO:0035690 ! cellular response to drug is_a: GO:0071383 ! cellular response to steroid hormone stimulus is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T04:11:13Z [Term] id: GO:0071394 name: cellular response to testosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0033574 ! response to testosterone is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-11T04:11:29Z [Term] id: GO:0071395 name: cellular response to jasmonic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah] is_a: GO:0009753 ! response to jasmonic acid is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T04:13:34Z [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-11T04:37:10Z [Term] id: GO:0071397 name: cellular response to cholesterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah] is_a: GO:0036315 ! cellular response to sterol is_a: GO:0070723 ! response to cholesterol is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2009-12-11T04:39:31Z [Term] id: GO:0071398 name: cellular response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah] is_a: GO:0070542 ! response to fatty acid is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T04:39:56Z [Term] id: GO:0071399 name: cellular response to linoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah] synonym: "cellular response to linoleate" EXACT [GOC:mah] is_a: GO:0070543 ! response to linoleic acid is_a: GO:0071398 ! cellular response to fatty acid created_by: midori creation_date: 2009-12-11T04:40:22Z [Term] id: GO:0071400 name: cellular response to oleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah] synonym: "cellular response to oleate" EXACT [GOC:mah] is_a: GO:0034201 ! response to oleic acid is_a: GO:0071398 ! cellular response to fatty acid created_by: midori creation_date: 2009-12-11T04:40:38Z [Term] id: GO:0071401 name: cellular response to triglyceride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah] synonym: "cellular response to triacylglyceride" EXACT [GOC:mah] synonym: "cellular response to triacylglycerol" EXACT [GOC:mah] is_a: GO:0034014 ! response to triglyceride is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-11T04:40:56Z [Term] id: GO:0071402 name: cellular response to lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah] is_a: GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2009-12-14T02:48:51Z [Term] id: GO:0071403 name: cellular response to high density lipoprotein particle stimulus namespace: biological_process alt_id: GO:0055099 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:mah] synonym: "cellular response to high-density lipoprotein particle stimulus" EXACT [] synonym: "response to high density lipoprotein particle" BROAD [] synonym: "response to high density lipoprotein particle stimulus" BROAD [GOC:dos] is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus created_by: midori creation_date: 2009-12-14T02:51:43Z [Term] id: GO:0071404 name: cellular response to low-density lipoprotein particle stimulus namespace: biological_process alt_id: GO:0055098 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:mah] synonym: "response to low density lipoprotein particle" BROAD [] synonym: "response to low-density lipoprotein particle" BROAD [GOC:dos] synonym: "response to low-density lipoprotein particle stimulus" BROAD [] is_a: GO:0055094 ! response to lipoprotein particle is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus created_by: midori creation_date: 2009-12-14T02:51:57Z [Term] id: GO:0071405 name: cellular response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah] is_a: GO:0033986 ! response to methanol is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2009-12-14T02:54:44Z [Term] id: GO:0071406 name: cellular response to methylmercury namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah] synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah] synonym: "cellular response to MeHg+" EXACT [GOC:mah] is_a: GO:0051597 ! response to methylmercury is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-14T02:55:12Z [Term] id: GO:0071407 name: cellular response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah] synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-14T02:55:58Z [Term] id: GO:0071408 name: cellular response to cycloalkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah] is_a: GO:0014071 ! response to cycloalkane is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-14T02:57:15Z [Term] id: GO:0071409 name: cellular response to cycloheximide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah] synonym: "cellular response to actidione" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0046898 ! response to cycloheximide is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2009-12-14T02:57:24Z [Term] id: GO:0071410 name: cellular response to cyclopentenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah] is_a: GO:0010583 ! response to cyclopentenone is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-14T03:09:49Z [Term] id: GO:0071411 name: cellular response to fluoxetine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah, GOC:pr] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014076 ! response to fluoxetine is_a: GO:0035690 ! cellular response to drug is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: midori creation_date: 2009-12-14T03:09:58Z [Term] id: GO:0071412 name: cellular response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0033595 ! response to genistein is_a: GO:0035690 ! cellular response to drug is_a: GO:0071413 ! cellular response to hydroxyisoflavone created_by: midori creation_date: 2009-12-14T03:10:04Z [Term] id: GO:0071413 name: cellular response to hydroxyisoflavone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah] is_a: GO:0033594 ! response to hydroxyisoflavone is_a: GO:1901655 ! cellular response to ketone is_a: GO:1905546 ! cellular response to phenylpropanoid created_by: midori creation_date: 2009-12-14T03:10:09Z [Term] id: GO:0071414 name: cellular response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah] is_a: GO:0031427 ! response to methotrexate is_a: GO:0035690 ! cellular response to drug is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-14T03:10:30Z [Term] id: GO:0071415 name: cellular response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:mah] synonym: "cellular response to purine" RELATED [] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-14T03:12:20Z [Term] id: GO:0071416 name: cellular response to tropane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah] is_a: GO:0014073 ! response to tropane is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound created_by: midori creation_date: 2009-12-14T03:12:24Z [Term] id: GO:0071417 name: cellular response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, GOC:mah] synonym: "cellular response to organic nitrogen" EXACT [GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:1901699 ! cellular response to nitrogen compound created_by: midori creation_date: 2009-12-14T04:07:27Z [Term] id: GO:0071418 name: cellular response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] is_a: GO:0014075 ! response to amine is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-14T04:08:17Z [Term] id: GO:0071419 name: cellular response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah] is_a: GO:0001975 ! response to amphetamine is_a: GO:0035690 ! cellular response to drug is_a: GO:0071418 ! cellular response to amine stimulus is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0097237 ! cellular response to toxic substance created_by: midori creation_date: 2009-12-14T04:09:02Z [Term] id: GO:0071420 name: cellular response to histamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah] synonym: "cellular response to histamine stimulus" EXACT [GOC:mah] is_a: GO:0034776 ! response to histamine is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound created_by: midori creation_date: 2009-12-14T04:09:25Z [Term] id: GO:0071421 name: manganese ion transmembrane transport namespace: biological_process def: "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "manganese ion membrane transport" EXACT [] synonym: "transmembrane manganese transport" EXACT [GOC:mah] is_a: GO:0006828 ! manganese ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: midori creation_date: 2009-12-15T02:41:31Z [Term] id: GO:0071422 name: succinate transmembrane transport namespace: biological_process def: "The process in which succinate is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "succinate membrane transport" EXACT [] synonym: "transmembrane succinate transport" EXACT [GOC:mah] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015744 ! succinate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: midori creation_date: 2009-12-15T03:29:44Z [Term] id: GO:0071423 name: malate transmembrane transport namespace: biological_process def: "A process in which a malate ion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "malate membrane transport" EXACT [] synonym: "transmembrane malate transport" EXACT [GOC:mah] is_a: GO:0015743 ! malate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: midori creation_date: 2009-12-15T03:31:37Z [Term] id: GO:0071424 name: rRNA (cytosine-N4-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine." [GOC:imk, PMID:19965768] is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity created_by: midori creation_date: 2009-12-15T03:46:52Z [Term] id: GO:0071425 name: hematopoietic stem cell proliferation namespace: biological_process def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl] synonym: "hemopoietic stem cell proliferation" EXACT [] is_a: GO:0072089 ! stem cell proliferation relationship: part_of GO:0030097 ! hemopoiesis created_by: midori creation_date: 2009-12-16T10:22:52Z [Term] id: GO:0071426 name: ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah] synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0006611 ! protein export from nucleus is_a: GO:0031503 ! protein-containing complex localization relationship: part_of GO:0071166 ! ribonucleoprotein complex localization created_by: midori creation_date: 2009-12-16T10:13:01Z [Term] id: GO:0071427 name: mRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus created_by: midori creation_date: 2009-12-16T10:13:59Z [Term] id: GO:0071428 name: rRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus created_by: midori creation_date: 2009-12-16T10:15:07Z [Term] id: GO:0071429 name: snRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus relationship: has_part GO:0006408 ! snRNA export from nucleus created_by: midori creation_date: 2009-12-16T10:15:38Z [Term] id: GO:0071430 name: pre-miRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah, GOC:sl] synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "pre-microRNA-containing ribonucleoprotein complex export from nucleus" EXACT [] synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus relationship: has_part GO:0035281 ! pre-miRNA export from nucleus created_by: midori creation_date: 2009-12-16T10:26:16Z [Term] id: GO:0071431 name: tRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus created_by: midori creation_date: 2009-12-16T10:27:03Z [Term] id: GO:0071432 name: peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah] synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw] synonym: "alpha-factor maturation" NARROW [GOC:vw] synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah] is_a: GO:0007323 ! peptide pheromone maturation is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion created_by: midori creation_date: 2009-12-16T10:46:50Z [Term] id: GO:0071433 name: cell wall repair namespace: biological_process def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw] is_a: GO:0071555 ! cell wall organization created_by: midori creation_date: 2009-12-16T11:00:50Z [Term] id: GO:0071434 name: cell chemotaxis to angiotensin namespace: biological_process def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah] synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah] synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah] is_a: GO:0060326 ! cell chemotaxis created_by: midori creation_date: 2009-12-16T11:07:15Z [Term] id: GO:0071437 name: invadopodium namespace: cellular_component def: "A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459] is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: midori creation_date: 2009-12-16T02:19:58Z [Term] id: GO:0071438 name: invadopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding an invadopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0071437 ! invadopodium created_by: midori creation_date: 2009-12-16T03:00:30Z [Term] id: GO:0071439 name: clathrin complex namespace: cellular_component def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411] synonym: "clathrin triskelion" EXACT [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030118 ! clathrin coat created_by: midori creation_date: 2009-12-16T03:17:58Z [Term] id: GO:0071440 name: regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah] is_a: GO:0035065 ! regulation of histone acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044154 ! histone H3-K14 acetylation relationship: regulates GO:0044154 ! histone H3-K14 acetylation created_by: midori creation_date: 2009-12-16T03:24:53Z [Term] id: GO:0071441 name: negative regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:0071440 ! regulation of histone H3-K14 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044154 ! histone H3-K14 acetylation relationship: negatively_regulates GO:0044154 ! histone H3-K14 acetylation created_by: midori creation_date: 2009-12-16T03:28:23Z [Term] id: GO:0071442 name: positive regulation of histone H3-K14 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah] synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah] synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah] synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:0071440 ! regulation of histone H3-K14 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044154 ! histone H3-K14 acetylation relationship: positively_regulates GO:0044154 ! histone H3-K14 acetylation created_by: midori creation_date: 2009-12-16T03:29:49Z [Term] id: GO:0071443 name: tDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding transfer RNA." [GOC:mah] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding created_by: midori creation_date: 2009-12-16T03:47:31Z [Term] id: GO:0071444 name: cellular response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah] synonym: "cellular pheromone response" EXACT [GOC:mah] is_a: GO:0019236 ! response to pheromone is_a: GO:0071310 ! cellular response to organic substance created_by: midori creation_date: 2009-12-16T04:05:33Z [Term] id: GO:0071445 name: obsolete cellular response to protein stimulus namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah] comment: This term was made obsolete because more specific terms exist. synonym: "cellular response to protein stimulus" EXACT [] is_obsolete: true consider: GO:0032870 consider: GO:0034620 consider: GO:0071218 consider: GO:0071345 consider: GO:0071363 created_by: midori creation_date: 2009-12-16T04:12:04Z [Term] id: GO:0071446 name: cellular response to salicylic acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah] synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph] is_a: GO:0009751 ! response to salicylic acid is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035690 ! cellular response to drug is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-16T04:14:16Z [Term] id: GO:0071447 name: cellular response to hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah] is_a: GO:0033194 ! response to hydroperoxide is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-16T04:16:42Z [Term] id: GO:0071448 name: cellular response to alkyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah] is_a: GO:0033195 ! response to alkyl hydroperoxide is_a: GO:0071447 ! cellular response to hydroperoxide created_by: midori creation_date: 2009-12-16T04:17:52Z [Term] id: GO:0071449 name: cellular response to lipid hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah] synonym: "cellular response to LHPO" EXACT [GOC:mah] is_a: GO:0006982 ! response to lipid hydroperoxide is_a: GO:0071447 ! cellular response to hydroperoxide created_by: midori creation_date: 2009-12-16T04:17:57Z [Term] id: GO:0071450 name: cellular response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah] is_a: GO:0000305 ! response to oxygen radical is_a: GO:0034614 ! cellular response to reactive oxygen species created_by: midori creation_date: 2009-12-16T04:38:52Z [Term] id: GO:0071451 name: cellular response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah] is_a: GO:0000303 ! response to superoxide is_a: GO:0071450 ! cellular response to oxygen radical created_by: midori creation_date: 2009-12-16T04:39:14Z [Term] id: GO:0071452 name: cellular response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah] is_a: GO:0000304 ! response to singlet oxygen is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0035690 ! cellular response to drug created_by: midori creation_date: 2009-12-16T04:39:46Z [Term] id: GO:0071453 name: cellular response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] synonym: "cellular response to oxygen" RELATED [GOC:al] is_a: GO:0070482 ! response to oxygen levels is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-16T04:43:59Z [Term] id: GO:0071454 name: cellular response to anoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah] comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'. synonym: "cellular response to anaerobic conditions" EXACT [GOC:elh] synonym: "cellular response to anoxic stress" EXACT [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034059 ! response to anoxia is_a: GO:0036294 ! cellular response to decreased oxygen levels created_by: midori creation_date: 2009-12-16T04:44:20Z [Term] id: GO:0071455 name: cellular response to hyperoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah] synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah] synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah] is_a: GO:0036295 ! cellular response to increased oxygen levels is_a: GO:0055093 ! response to hyperoxia is_a: GO:0062197 ! cellular response to chemical stress created_by: midori creation_date: 2009-12-16T04:44:41Z [Term] id: GO:0071456 name: cellular response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "cellular response to hypoxic stress" EXACT [GOC:mah] synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah] is_a: GO:0001666 ! response to hypoxia is_a: GO:0033554 ! cellular response to stress is_a: GO:0036294 ! cellular response to decreased oxygen levels created_by: midori creation_date: 2009-12-16T04:45:20Z [Term] id: GO:0071457 name: cellular response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah] is_a: GO:0010193 ! response to ozone is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0035690 ! cellular response to drug is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071236 ! cellular response to antibiotic created_by: midori creation_date: 2009-12-16T04:45:59Z [Term] id: GO:0071458 name: integral component of cytoplasmic side of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos, GOC:mah] synonym: "integral to cytosolic leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab] synonym: "integral to cytosolic side of endoplasmic reticulum membrane" EXACT [] synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah] synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw] is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane intersection_of: GO:0030176 ! integral component of endoplasmic reticulum membrane intersection_of: part_of GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane relationship: part_of GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane created_by: midori creation_date: 2009-12-17T01:43:33Z [Term] id: GO:0071459 name: protein localization to chromosome, centromeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah] synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah] synonym: "protein localization to centromere" EXACT [GOC:mah] synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome created_by: midori creation_date: 2009-12-17T02:11:23Z [Term] id: GO:0071460 name: cellular response to cell-matrix adhesion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869] is_a: GO:0031668 ! cellular response to extracellular stimulus created_by: midori creation_date: 2009-12-17T02:25:45Z [Term] id: GO:0071461 name: cellular response to redox state namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah] synonym: "cellular redox signal response" EXACT [GOC:mah] is_a: GO:0051775 ! response to redox state created_by: midori creation_date: 2009-12-18T11:30:21Z [Term] id: GO:0071462 name: cellular response to water stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] is_a: GO:0009415 ! response to water is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-18T11:32:44Z [Term] id: GO:0071463 name: cellular response to humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah] is_a: GO:0009270 ! response to humidity is_a: GO:0071462 ! cellular response to water stimulus created_by: midori creation_date: 2009-12-18T11:33:55Z [Term] id: GO:0071464 name: cellular response to hydrostatic pressure namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah] synonym: "cellular response to biomechanical stress" BROAD [GOC:mah] synonym: "cellular response to static fluid pressure" EXACT [GOC:mah] is_a: GO:0051599 ! response to hydrostatic pressure is_a: GO:0062197 ! cellular response to chemical stress is_a: GO:0071462 ! cellular response to water stimulus created_by: midori creation_date: 2009-12-18T11:34:07Z [Term] id: GO:0071465 name: cellular response to desiccation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] synonym: "desiccation tolerance" RELATED [GOC:mah] is_a: GO:0009269 ! response to desiccation is_a: GO:0042631 ! cellular response to water deprivation created_by: midori creation_date: 2009-12-18T11:35:19Z [Term] id: GO:0071466 name: cellular response to xenobiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:mah] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0070887 ! cellular response to chemical stimulus created_by: midori creation_date: 2009-12-18T11:38:48Z [Term] id: GO:0071467 name: cellular response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, http://en.wikipedia.org/wiki/PH] is_a: GO:0009268 ! response to pH is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-18T11:41:54Z [Term] id: GO:0071468 name: cellular response to acidic pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/PH] comment: This term should be used to annotate instances where a cell is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0071229 'cellular response to acid chemical'. synonym: "cellular response to acidity" BROAD [] is_a: GO:0010447 ! response to acidic pH is_a: GO:0071467 ! cellular response to pH created_by: midori creation_date: 2009-12-18T11:42:35Z [Term] id: GO:0071469 name: cellular response to alkaline pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/PH] synonym: "cellular response to alkalinity" BROAD [] synonym: "cellular response to basic pH" EXACT [GOC:mah] is_a: GO:0010446 ! response to alkaline pH is_a: GO:0071467 ! cellular response to pH created_by: midori creation_date: 2009-12-18T11:42:47Z [Term] id: GO:0071470 name: cellular response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "cellular osmotic response" EXACT [GOC:mah] synonym: "cellular osmotic stress response" EXACT [GOC:mah] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0062197 ! cellular response to chemical stress is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-18T11:45:33Z [Term] id: GO:0071471 name: cellular response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah] is_a: GO:0010335 ! response to non-ionic osmotic stress is_a: GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2009-12-18T11:47:59Z [Term] id: GO:0071472 name: cellular response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah] synonym: "cellular salinity response" EXACT [GOC:mah] is_a: GO:0009651 ! response to salt stress is_a: GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2009-12-18T11:48:23Z [Term] id: GO:0071473 name: cellular response to cation stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah] is_a: GO:0043157 ! response to cation stress is_a: GO:0071472 ! cellular response to salt stress created_by: midori creation_date: 2009-12-18T11:49:46Z [Term] id: GO:0071474 name: cellular hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular HOG response" EXACT [GOC:mah] synonym: "cellular hypertonic response" EXACT [GOC:mah] synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2009-12-18T11:51:36Z [Term] id: GO:0071475 name: cellular hyperosmotic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah] is_a: GO:0042538 ! hyperosmotic salinity response is_a: GO:0071472 ! cellular response to salt stress is_a: GO:0071474 ! cellular hyperosmotic response created_by: midori creation_date: 2009-12-18T11:52:06Z [Term] id: GO:0071476 name: cellular hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular hypo-osmotic response" EXACT [GOC:mah] is_a: GO:0006971 ! hypotonic response is_a: GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2009-12-18T11:52:59Z [Term] id: GO:0071477 name: cellular hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah] is_a: GO:0042539 ! hypotonic salinity response is_a: GO:0071472 ! cellular response to salt stress is_a: GO:0071476 ! cellular hypotonic response created_by: midori creation_date: 2009-12-18T11:53:20Z [Term] id: GO:0071478 name: cellular response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to radiation stimulus" EXACT [GOC:mah] is_a: GO:0009314 ! response to radiation is_a: GO:0071214 ! cellular response to abiotic stimulus created_by: midori creation_date: 2009-12-18T01:59:37Z [Term] id: GO:0071479 name: cellular response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] synonym: "cellular response to ionising radiation" EXACT [GOC:mah] synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah] is_a: GO:0010212 ! response to ionizing radiation is_a: GO:0071478 ! cellular response to radiation created_by: midori creation_date: 2009-12-18T02:00:31Z [Term] id: GO:0071480 name: cellular response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] synonym: "cellular response to gamma ray" RELATED [GOC:mah] synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah] is_a: GO:0010332 ! response to gamma radiation is_a: GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2009-12-18T02:00:50Z [Term] id: GO:0071481 name: cellular response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah] is_a: GO:0010165 ! response to X-ray is_a: GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2009-12-18T02:00:59Z [Term] id: GO:0071482 name: cellular response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] is_a: GO:0009416 ! response to light stimulus is_a: GO:0071478 ! cellular response to radiation created_by: midori creation_date: 2009-12-18T02:03:49Z [Term] id: GO:0071483 name: cellular response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah] synonym: "cellular response to blue light stimulus" EXACT [GOC:mah] is_a: GO:0009637 ! response to blue light is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:09:48Z [Term] id: GO:0071484 name: cellular response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah] is_a: GO:0009642 ! response to light intensity is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:11:03Z [Term] id: GO:0071485 name: cellular response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah] synonym: "cellular response to darkness" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:12Z [Term] id: GO:0071486 name: cellular response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah] is_a: GO:0009644 ! response to high light intensity is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:23Z [Term] id: GO:0071487 name: cellular response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:29Z [Term] id: GO:0071488 name: cellular response to very low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah] is_a: GO:0055122 ! response to very low light intensity stimulus is_a: GO:0071484 ! cellular response to light intensity created_by: midori creation_date: 2009-12-18T02:13:40Z [Term] id: GO:0071489 name: cellular response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] is_a: GO:0009639 ! response to red or far red light is_a: GO:0071482 ! cellular response to light stimulus created_by: midori creation_date: 2009-12-18T02:18:25Z [Term] id: GO:0071490 name: cellular response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to far red light stimulus" EXACT [GOC:mah] is_a: GO:0010218 ! response to far red light is_a: GO:0071489 ! cellular response to red or far red light created_by: midori creation_date: 2009-12-18T02:19:40Z [Term] id: GO:0071491 name: cellular response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] synonym: "cellular response to red light stimulus" EXACT [GOC:mah] is_a: GO:0010114 ! response to red light is_a: GO:0071489 ! cellular response to red or far red light created_by: midori creation_date: 2009-12-18T02:19:47Z [Term] id: GO:0071492 name: cellular response to UV-A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:mah] synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah] is_a: GO:0034644 ! cellular response to UV is_a: GO:0070141 ! response to UV-A created_by: midori creation_date: 2009-12-18T02:21:51Z [Term] id: GO:0071493 name: cellular response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:mah] synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah] is_a: GO:0010224 ! response to UV-B is_a: GO:0034644 ! cellular response to UV created_by: midori creation_date: 2009-12-18T02:21:56Z [Term] id: GO:0071494 name: cellular response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:mah] synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah] synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah] synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah] synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah] is_a: GO:0010225 ! response to UV-C is_a: GO:0034644 ! cellular response to UV created_by: midori creation_date: 2009-12-18T02:22:01Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009719 ! response to endogenous stimulus created_by: midori creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071496 name: cellular response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009605 ! response to external stimulus created_by: midori creation_date: 2009-12-18T02:36:52Z [Term] id: GO:0071497 name: cellular response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah] synonym: "antifreeze activity" RELATED [GOC:mah] synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah] is_a: GO:0050826 ! response to freezing is_a: GO:0070417 ! cellular response to cold created_by: midori creation_date: 2009-12-18T02:41:02Z [Term] id: GO:0071498 name: cellular response to fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034405 ! response to fluid shear stress created_by: midori creation_date: 2009-12-18T02:41:44Z [Term] id: GO:0071499 name: cellular response to laminar fluid shear stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah] is_a: GO:0034616 ! response to laminar fluid shear stress is_a: GO:0071498 ! cellular response to fluid shear stress created_by: midori creation_date: 2009-12-18T02:43:02Z [Term] id: GO:0071500 name: cellular response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah] is_a: GO:0051409 ! response to nitrosative stress is_a: GO:0062197 ! cellular response to chemical stress created_by: midori creation_date: 2009-12-18T02:49:46Z [Term] id: GO:0071501 name: cellular response to sterol depletion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah] synonym: "cellular sterol depletion response" EXACT [GOC:mah] is_a: GO:0006991 ! response to sterol depletion is_a: GO:0033554 ! cellular response to stress created_by: midori creation_date: 2009-12-18T02:54:14Z [Term] id: GO:0071502 name: cellular response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah] synonym: "cellular response to thermal stimulus" EXACT [GOC:mah] is_a: GO:0009266 ! response to temperature stimulus created_by: midori creation_date: 2009-12-18T02:56:45Z [Term] id: GO:0071503 name: response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2009-12-18T03:33:49Z [Term] id: GO:0071504 name: cellular response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0071503 ! response to heparin is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-18T03:34:38Z [Term] id: GO:0071505 name: response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah, GOC:yaf] synonym: "response to mycophenolate" EXACT [GOC:mah] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010046 ! response to mycotoxin is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2009-12-18T03:46:00Z [Term] id: GO:0071506 name: cellular response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [CHEBI:168396, GOC:mah, GOC:yaf] synonym: "cellular response to mycophenolate" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0036146 ! cellular response to mycotoxin is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0071505 ! response to mycophenolic acid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2009-12-18T03:47:25Z [Term] id: GO:0071507 name: pheromone response MAPK cascade namespace: biological_process def: "A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion." [GOC:mah, GOC:vw] {comment="PMID:17604854"} synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah] synonym: "Fus3 signaling cascade" NARROW [PMID:20880736] synonym: "MAPK cascade involved in conjugation with cellular fusion" EXACT [] synonym: "MAPK signaling in response to pheromone" RELATED [PMID:20880736] synonym: "MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling] synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah] synonym: "pheromone MAPK module" RELATED [PMID:20880736] is_a: GO:0000165 ! MAPK cascade is_a: GO:0022414 ! reproductive process intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion created_by: midori creation_date: 2010-01-05T01:43:47Z [Term] id: GO:0071508 name: activation of MAPK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-01-05T02:09:35Z [Term] id: GO:0071509 name: activation of MAPKK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-01-05T02:09:58Z [Term] id: GO:0071510 name: activation of MAPKKK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah] is_a: GO:0000185 ! activation of MAPKKK activity is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-01-05T02:10:18Z [Term] id: GO:0071511 name: inactivation of MAPK activity involved in conjugation with cellular fusion namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah] synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah] synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah] is_a: GO:0000188 ! inactivation of MAPK activity is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-01-05T02:10:47Z [Term] id: GO:0071512 name: obsolete MAPK import into nucleus involved in conjugation with cellular fusion namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "conjugation with cellular fusion, MAPK import into nucleus" EXACT [GOC:mah] synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in mating response" RELATED [GOC:mah] synonym: "nuclear translocation of MAPK involved in conjugation with cellular fusion" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah] is_obsolete: true consider: GO:0006606 created_by: midori creation_date: 2010-01-05T02:11:08Z [Term] id: GO:0071513 name: phosphopantothenoylcysteine decarboxylase complex namespace: cellular_component def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2010-01-05T05:23:13Z [Term] id: GO:0071514 name: genetic imprinting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GOC:mah, GOC:vw] synonym: "DNA imprinting" EXACT [GOC:mah] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process created_by: midori creation_date: 2010-01-06T11:56:31Z [Term] id: GO:0071515 name: genetic imprinting at mating-type locus namespace: biological_process def: "A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] synonym: "mating type determination, imprinting" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0031494 ! regulation of mating type switching is_a: GO:0071514 ! genetic imprinting created_by: midori creation_date: 2010-01-06T12:58:56Z [Term] id: GO:0071516 name: establishment of imprinting at mating-type locus namespace: biological_process def: "The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:18723894] synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus created_by: midori creation_date: 2010-01-06T01:16:27Z [Term] id: GO:0071517 name: maintenance of imprinting at mating-type locus namespace: biological_process def: "Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus created_by: midori creation_date: 2010-01-06T01:17:05Z [Term] id: GO:0071518 name: autoinducer-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244] synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:425228, GOC:mah] xref: MetaCyc:RXN0-5461 is_a: GO:0016301 ! kinase activity created_by: midori creation_date: 2010-01-06T05:08:17Z [Term] id: GO:0071519 name: actomyosin contractile ring actin filament bundle assembly namespace: biological_process def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940] synonym: "actin filament bundle assembly involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb] synonym: "actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly" EXACT [] is_a: GO:0051017 ! actin filament bundle assembly is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization intersection_of: GO:0051017 ! actin filament bundle assembly intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2010-01-06T05:27:59Z [Term] id: GO:0071520 name: actomyosin contractile ring assembly actin filament bundle convergence namespace: biological_process def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940] synonym: "actin filament bundle convergence involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb] synonym: "actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly" EXACT [] is_a: GO:0090426 ! actin filament bundle convergence is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization intersection_of: GO:0090426 ! actin filament bundle convergence intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2010-01-06T05:33:16Z [Term] id: GO:0071521 name: Cdc42 GTPase complex namespace: cellular_component def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016] synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2010-01-07T01:29:12Z [Term] id: GO:0071522 name: ureidoglycine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185] xref: EC:3.5.3.26 xref: MetaCyc:URUR-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines created_by: midori creation_date: 2010-01-07T01:43:58Z [Term] id: GO:0071523 name: obsolete TIR domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. is_obsolete: true created_by: midori creation_date: 2010-01-07T02:11:47Z [Term] id: GO:0071524 name: pyrrolysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:dh, PMID:17204561] synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [CHEBI:21860] synonym: "pyrrolysine anabolism" EXACT [GOC:mah] synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah] synonym: "pyrrolysine formation" EXACT [GOC:mah] synonym: "pyrrolysine synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0071525 ! pyrrolysine metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: midori creation_date: 2010-01-07T02:40:24Z [Term] id: GO:0071525 name: pyrrolysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [CHEBI:21860, GOC:mah, PMID:17204561] synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [CHEBI:21860] synonym: "pyrrolysine metabolism" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: midori creation_date: 2010-01-07T02:44:49Z [Term] id: GO:0071526 name: semaphorin-plexin signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] synonym: "semaphorin-plexin signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: midori creation_date: 2010-01-07T03:48:07Z [Term] id: GO:0071527 name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis namespace: biological_process def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] synonym: "semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:mah] is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development is_a: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: midori creation_date: 2010-01-07T03:49:33Z [Term] id: GO:0071528 name: tRNA re-export from nucleus namespace: biological_process def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305] synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc] is_a: GO:0006409 ! tRNA export from nucleus created_by: midori creation_date: 2010-01-07T04:17:05Z [Term] id: GO:0071529 name: cementum mineralization namespace: biological_process def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865] synonym: "cementum formation" RELATED [GOC:mah] is_a: GO:0034505 ! tooth mineralization created_by: midori creation_date: 2010-01-07T04:18:54Z [Term] id: GO:0071530 name: obsolete FHA domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-08T01:57:36Z [Term] id: GO:0071531 name: obsolete Rel homology domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a Rel homology domain (RHD) interaction." [GOC:amm, InterPro:IPR011539] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-08T02:16:39Z [Term] id: GO:0071532 name: ankyrin repeat binding namespace: molecular_function def: "Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110] synonym: "ANK repeat binding" EXACT [GOC:amm] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-01-08T02:21:02Z [Term] id: GO:0071533 name: obsolete ankyrin repeat-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm] is_obsolete: true created_by: midori creation_date: 2010-01-08T02:27:56Z [Term] id: GO:0071534 name: obsolete zf-TRAF domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah] synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah] synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-08T02:40:50Z [Term] id: GO:0071535 name: RING-like zinc finger domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-01-08T03:10:14Z [Term] id: GO:0071536 name: obsolete RING-like zinc finger domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-08T03:19:47Z [Term] id: GO:0071537 name: obsolete C3HC4-type RING finger domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm] is_obsolete: true created_by: midori creation_date: 2010-01-08T03:42:46Z [Term] id: GO:0071538 name: obsolete SH2 domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. is_obsolete: true created_by: midori creation_date: 2010-01-08T03:46:16Z [Term] id: GO:0071539 name: protein localization to centrosome namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] synonym: "protein localisation to centrosome" EXACT [GOC:mah] is_a: GO:1905508 ! protein localization to microtubule organizing center created_by: midori creation_date: 2010-01-12T02:09:45Z [Term] id: GO:0071540 name: eukaryotic translation initiation factor 3 complex, eIF3e namespace: cellular_component def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex created_by: midori creation_date: 2010-01-12T02:20:24Z [Term] id: GO:0071541 name: eukaryotic translation initiation factor 3 complex, eIF3m namespace: cellular_component def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex created_by: midori creation_date: 2010-01-12T02:26:41Z [Term] id: GO:0071542 name: dopaminergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph] is_a: GO:0030182 ! neuron differentiation created_by: midori creation_date: 2010-01-12T02:28:44Z [Term] id: GO:0071543 name: diphosphoinositol polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah] is_a: GO:0043647 ! inositol phosphate metabolic process created_by: midori creation_date: 2010-01-12T05:04:00Z [Term] id: GO:0071544 name: diphosphoinositol polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah] synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah] synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah] is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process is_a: GO:0071545 ! inositol phosphate catabolic process created_by: midori creation_date: 2010-01-12T05:07:10Z [Term] id: GO:0071545 name: inositol phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] comment: See also the biological process term 'inositol phosphate dephosphorylation ; GO:0046855'. synonym: "inositol phosphate breakdown" EXACT [GOC:mah] synonym: "inositol phosphate catabolism" EXACT [GOC:mah] synonym: "inositol phosphate degradation" EXACT [GOC:mah] synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah] is_a: GO:0043647 ! inositol phosphate metabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:0046434 ! organophosphate catabolic process created_by: midori creation_date: 2010-01-12T05:07:45Z [Term] id: GO:0071546 name: pi-body namespace: cellular_component def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505] synonym: "intermitochondrial cement" EXACT [GOC:sp] is_a: GO:0043186 ! P granule created_by: midori creation_date: 2010-01-12T05:44:12Z [Term] id: GO:0071547 name: piP-body namespace: cellular_component def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505] is_a: GO:0043186 ! P granule created_by: midori creation_date: 2010-01-12T05:47:47Z [Term] id: GO:0071548 name: response to dexamethasone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] synonym: "response to dexamethasone stimulus" EXACT [GOC:dos] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: midori creation_date: 2010-01-13T01:24:40Z [Term] id: GO:0071549 name: cellular response to dexamethasone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0071548 ! response to dexamethasone is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2010-01-13T01:24:49Z [Term] id: GO:0071550 name: death-inducing signaling complex assembly namespace: biological_process def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway." [GOC:amm, GOC:mtg_apoptosis, InterPro:IPR000488] synonym: "DD-mediated complex assembly" EXACT [GOC:mah] synonym: "death domain-mediated complex assembly" EXACT [] synonym: "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [] synonym: "death-inducing signaling complex formation" EXACT [] synonym: "death-inducing signalling complex assembly" EXACT [] synonym: "DISC assembly" EXACT [] synonym: "DISC formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway created_by: midori creation_date: 2010-01-13T02:48:38Z [Term] id: GO:0071551 name: RIP homotypic interaction motif binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559] synonym: "RHIM binding" EXACT [GOC:mah] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-01-13T03:03:51Z [Term] id: GO:0071552 name: obsolete RIP homotypic interaction motif-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-13T03:08:30Z [Term] id: GO:0071553 name: G protein-coupled pyrimidinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906] synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] synonym: "G-protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT [] synonym: "pyrimidinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001608 ! G protein-coupled nucleotide receptor activity is_a: GO:0016502 ! nucleotide receptor activity relationship: has_part GO:0019103 ! pyrimidine nucleotide binding created_by: midori creation_date: 2010-01-13T03:13:22Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0009987 ! cellular process created_by: midori creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071555 name: cell wall organization namespace: biological_process alt_id: GO:0007047 alt_id: GO:0044234 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir synonym: "cell wall organisation" EXACT [] synonym: "cell wall organisation in other organism" EXACT [GOC:mah] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cell wall organization in other organism" EXACT [] synonym: "cellular cell wall organisation" EXACT [] synonym: "cellular cell wall organization" EXACT [] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0071554 ! cell wall organization or biogenesis created_by: midori creation_date: 2010-01-13T03:33:07Z [Term] id: GO:0071556 name: integral component of lumenal side of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah] synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw] synonym: "integral to lumenal leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab] synonym: "integral to lumenal side of endoplasmic reticulum membrane" NARROW [] synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah] is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098553 ! lumenal side of endoplasmic reticulum membrane relationship: part_of GO:0098553 ! lumenal side of endoplasmic reticulum membrane created_by: midori creation_date: 2010-01-15T10:56:58Z [Term] id: GO:0071557 name: histone H3-K27 demethylation namespace: biological_process def: "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638] synonym: "H3K27 demethylation" RELATED [GOC:mah] is_a: GO:0070076 ! histone lysine demethylation created_by: midori creation_date: 2010-01-15T10:59:50Z [Term] id: GO:0071558 name: histone demethylase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20622853] xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16-INK4A promoter" xref: Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin" xref: Reactome:R-HSA-5617887 "HOXC4 chromatin is activated" is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0071557 ! histone H3-K27 demethylation created_by: midori creation_date: 2010-01-15T11:33:17Z [Term] id: GO:0071559 name: response to transforming growth factor beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] synonym: "response to TGF-beta stimulus" EXACT [GOC:mah] synonym: "response to TGFbeta stimulus" EXACT [GOC:mah] synonym: "response to transforming growth factor beta stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: midori creation_date: 2010-01-20T11:49:59Z [Term] id: GO:0071560 name: cellular response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah] synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071559 ! response to transforming growth factor beta created_by: midori creation_date: 2010-01-20T11:51:18Z [Term] id: GO:0071561 name: nucleus-vacuole junction namespace: cellular_component def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880] synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah] synonym: "NV junction" EXACT [GOC:jp, PMID:16709156] synonym: "NVJ" EXACT [GOC:mah, PMID:16806880] is_a: GO:0044232 ! organelle membrane contact site created_by: midori creation_date: 2010-01-20T02:09:42Z [Term] id: GO:0071562 name: nucleus-vacuole junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156] synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp] synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156] synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156] synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880] synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880] is_a: GO:0022607 ! cellular component assembly is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0034727 ! piecemeal microautophagy of the nucleus created_by: midori creation_date: 2010-01-20T02:16:36Z [Term] id: GO:0071563 name: Myo2p-Vac17p-Vac8p transport complex namespace: cellular_component def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2010-01-20T03:03:24Z [Term] id: GO:0071564 name: npBAF complex namespace: cellular_component def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: midori creation_date: 2010-01-20T03:33:42Z [Term] id: GO:0071565 name: nBAF complex namespace: cellular_component def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: midori creation_date: 2010-01-20T03:41:19Z [Term] id: GO:0071566 name: UFM1 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity created_by: midori creation_date: 2010-01-20T04:06:05Z [Term] id: GO:0071567 name: UFM1 hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates." [GOC:sp, PMID:20018847] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity created_by: midori creation_date: 2010-01-20T04:08:34Z [Term] id: GO:0071568 name: UFM1 transferase activity namespace: molecular_function def: "Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages." [GOC:sp, PMID:20018847] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: midori creation_date: 2010-01-20T04:10:11Z [Term] id: GO:0071569 name: protein ufmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847] is_a: GO:0032446 ! protein modification by small protein conjugation created_by: midori creation_date: 2010-01-20T04:12:01Z [Term] id: GO:0071570 name: cement gland development namespace: biological_process def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf] is_a: GO:0048732 ! gland development created_by: midori creation_date: 2010-01-20T04:31:04Z [Term] id: GO:0071571 name: obsolete LRR domain-mediated complex assembly namespace: biological_process def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611] comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-01-20T04:33:49Z [Term] id: GO:0071572 name: histone H3-K56 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah] is_a: GO:0070932 ! histone H3 deacetylation created_by: midori creation_date: 2010-01-20T04:50:03Z [Term] id: GO:0071573 name: shelterin complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw] synonym: "Pot1 complex assembly" RELATED [GOC:mah, GOC:vw] synonym: "Pot1-Tpz1 complex assembly" RELATED [GIOC:vw, GOC:mah] synonym: "shelterin complex formation" RELATED [GOC:mah, GOC:vw] synonym: "telosome assembly" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0032200 ! telomere organization created_by: midori creation_date: 2010-01-26T01:45:20Z [Term] id: GO:0071574 name: protein localization to medial cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah] synonym: "protein localisation to medial cortex" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2010-01-26T05:17:50Z [Term] id: GO:0071575 name: integral component of external side of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane." [GOC:dos, GOC:mah] synonym: "integral to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "integral to external side of plasma membrane" NARROW [] is_a: GO:0005887 ! integral component of plasma membrane is_a: GO:0031233 ! intrinsic component of external side of plasma membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009897 ! external side of plasma membrane created_by: midori creation_date: 2010-01-26T05:20:28Z [Term] id: GO:0071576 name: tetrahydrodictyopterin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [CHEBI:52447, GOC:mah, GOC:vw] synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah] synonym: "DH4 binding" EXACT [GOC:mah] is_a: GO:0034617 ! tetrahydrobiopterin binding created_by: midori creation_date: 2010-01-26T05:24:59Z [Term] id: GO:0071577 name: zinc ion transmembrane transport namespace: biological_process def: "A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "zinc II ion transmembrane transport" EXACT [] synonym: "zinc ion membrane transport" EXACT [] synonym: "zinc transmembrane transport" EXACT [GOC:mah] is_a: GO:0006829 ! zinc ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: midori creation_date: 2010-01-28T02:17:12Z [Term] id: GO:0071578 name: zinc ion import across plasma membrane namespace: biological_process alt_id: GO:0006830 alt_id: GO:0006831 alt_id: GO:0044749 alt_id: GO:0140160 def: "The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:18637840] synonym: "high-affinity zinc II ion transmembrane import" NARROW [] synonym: "high-affinity zinc II ion transport" NARROW [] synonym: "low-affinity zinc II ion transport" NARROW [] synonym: "zinc II ion plasma membrane import" EXACT [] synonym: "zinc II ion transmembrane import" EXACT [] synonym: "zinc import" EXACT [GOC:mah] synonym: "zinc ion transmembrane import" RELATED [] synonym: "zinc uptake" EXACT [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: janelomax creation_date: 2010-01-28T02:22:02Z [Term] id: GO:0071579 name: regulation of zinc ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006829 ! zinc ion transport relationship: regulates GO:0006829 ! zinc ion transport created_by: midori creation_date: 2010-01-28T03:02:15Z [Term] id: GO:0071580 name: regulation of zinc ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] synonym: "regulation of zinc ion membrane transport" EXACT [] is_a: GO:0071579 ! regulation of zinc ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071577 ! zinc ion transmembrane transport relationship: regulates GO:0071577 ! zinc ion transmembrane transport created_by: midori creation_date: 2010-01-28T03:05:53Z [Term] id: GO:0071581 name: regulation of zinc ion transmembrane import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah] is_a: GO:0071580 ! regulation of zinc ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071578 ! zinc ion import across plasma membrane relationship: regulates GO:0071578 ! zinc ion import across plasma membrane created_by: midori creation_date: 2010-01-28T03:09:19Z [Term] id: GO:0071582 name: negative regulation of zinc ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0071579 ! regulation of zinc ion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006829 ! zinc ion transport relationship: negatively_regulates GO:0006829 ! zinc ion transport created_by: midori creation_date: 2010-01-28T03:14:25Z [Term] id: GO:0071583 name: negative regulation of zinc ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] synonym: "negative regulation of zinc ion membrane transport" EXACT [] is_a: GO:0071580 ! regulation of zinc ion transmembrane transport is_a: GO:0071582 ! negative regulation of zinc ion transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071577 ! zinc ion transmembrane transport relationship: negatively_regulates GO:0071577 ! zinc ion transmembrane transport created_by: midori creation_date: 2010-01-28T03:15:54Z [Term] id: GO:0071584 name: negative regulation of zinc ion transmembrane import namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah] is_a: GO:0071581 ! regulation of zinc ion transmembrane import is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071578 ! zinc ion import across plasma membrane relationship: negatively_regulates GO:0071578 ! zinc ion import across plasma membrane created_by: midori creation_date: 2010-01-28T03:17:21Z [Term] id: GO:0071585 name: detoxification of cadmium ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:1990170 ! stress response to cadmium ion created_by: midori creation_date: 2010-01-28T03:38:48Z [Term] id: GO:0071586 name: CAAX-box protein processing namespace: biological_process def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah] is_a: GO:0016485 ! protein processing relationship: part_of GO:0080120 ! CAAX-box protein maturation created_by: midori creation_date: 2010-01-28T04:42:45Z [Term] id: GO:0071587 name: CAAX-box protein modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah] is_a: GO:0043687 ! post-translational protein modification relationship: part_of GO:0080120 ! CAAX-box protein maturation created_by: midori creation_date: 2010-01-28T04:48:56Z [Term] id: GO:0071588 name: hydrogen peroxide mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891] synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah] synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction created_by: midori creation_date: 2010-01-29T11:18:58Z [Term] id: GO:0071589 name: pyridine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [CHEBI:47896, GOC:mah] synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah] synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah] synonym: "pyridine nucleoside formation" EXACT [GOC:mah] synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0070637 ! pyridine nucleoside metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process created_by: midori creation_date: 2010-01-29T11:35:30Z [Term] id: GO:0071590 name: nicotinamide riboside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [CHEBI:15927, GOC:mah, PMID:19846558] synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [CHEBI:15927] synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah] synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah] synonym: "nicotinamide riboside formation" EXACT [GOC:mah] synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0071589 ! pyridine nucleoside biosynthetic process created_by: midori creation_date: 2010-01-29T11:39:27Z [Term] id: GO:0071591 name: nicotinic acid riboside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558] synonym: "D-ribosylnicotinic acid metabolic process" EXACT [CHEBI:27748] synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah] is_a: GO:0070637 ! pyridine nucleoside metabolic process created_by: midori creation_date: 2010-01-29T11:50:42Z [Term] id: GO:0071592 name: nicotinic acid riboside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [CHEBI:27748, GOC:mah, PMID:19846558] synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [CHEBI:27748] synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah] synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah] synonym: "nicotinic acid riboside formation" EXACT [GOC:mah] synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah] is_a: GO:0071589 ! pyridine nucleoside biosynthetic process is_a: GO:0071591 ! nicotinic acid riboside metabolic process created_by: midori creation_date: 2010-01-29T12:01:25Z [Term] id: GO:0071593 name: lymphocyte aggregation namespace: biological_process def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl] is_a: GO:0070486 ! leukocyte aggregation created_by: midori creation_date: 2010-01-29T01:37:30Z [Term] id: GO:0071594 name: thymocyte aggregation namespace: biological_process def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990] synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl] synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah] synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah] synonym: "T cell precursor aggregation" EXACT [GOC:sl] synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl] is_a: GO:0070489 ! T cell aggregation created_by: midori creation_date: 2010-01-29T01:38:49Z [Term] id: GO:0071595 name: Nem1-Spo7 phosphatase complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network created_by: midori creation_date: 2010-01-29T02:17:29Z [Term] id: GO:0071596 name: ubiquitin-dependent protein catabolic process via the N-end rule pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437] synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2010-01-29T03:01:09Z [Term] id: GO:0071597 name: cellular birth scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2010-02-02T02:42:44Z [Term] id: GO:0071598 name: neuronal ribonucleoprotein granule namespace: cellular_component def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989] synonym: "neuronal RNA granule" NARROW [] synonym: "neuronal RNP granule" EXACT [] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule relationship: part_of GO:0120111 ! neuron projection cytoplasm created_by: midori creation_date: 2010-02-04T04:01:57Z [Term] id: GO:0071599 name: otic vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0007423 ! sensory organ development is_a: GO:0035295 ! tube development is_a: GO:0048839 ! inner ear development is_a: GO:0060429 ! epithelium development created_by: midori creation_date: 2010-02-04T04:07:17Z [Term] id: GO:0071600 name: otic vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] is_a: GO:0042472 ! inner ear morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0071599 ! otic vesicle development created_by: midori creation_date: 2010-02-04T04:07:27Z [Term] id: GO:0071601 name: sphere organelle namespace: cellular_component def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728] is_a: GO:0016604 ! nuclear body created_by: midori creation_date: 2010-02-04T04:26:41Z [Term] id: GO:0071602 name: phytosphingosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [CHEBI:46961, GOC:mah] synonym: "phytosphingosine anabolism" EXACT [GOC:mah] synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah] synonym: "phytosphingosine formation" EXACT [GOC:mah] synonym: "phytosphingosine synthesis" EXACT [GOC:mah] is_a: GO:0006671 ! phytosphingosine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046520 ! sphingoid biosynthetic process created_by: midori creation_date: 2010-02-04T05:15:59Z [Term] id: GO:0071603 name: endothelial cell-cell adhesion namespace: biological_process def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF] is_a: GO:0090136 ! epithelial cell-cell adhesion created_by: midori creation_date: 2010-02-04T05:21:30Z [Term] id: GO:0071604 name: transforming growth factor beta production namespace: biological_process def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv] synonym: "TGF-B production" EXACT [GOC:mah] synonym: "TGF-beta production" EXACT [GOC:mah] synonym: "TGFB production" EXACT [GOC:mah] synonym: "TGFb production" EXACT [GOC:rv] synonym: "transforming growth factor-beta production" EXACT [GOC:bf] is_a: GO:0001816 ! cytokine production created_by: midori creation_date: 2010-02-05T03:56:57Z [Term] id: GO:0071605 name: monocyte chemotactic protein-1 production namespace: biological_process def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL2 production" EXACT [GOC:add, GOC:rv] synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:09:53Z [Term] id: GO:0071606 name: chemokine (C-C motif) ligand 4 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL4 production" EXACT [GOC:add, GOC:rv] synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:16:42Z [Term] id: GO:0071607 name: macrophage inflammatory protein-1 gamma production namespace: biological_process def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL9 production" EXACT [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv] synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:19:52Z [Term] id: GO:0071608 name: macrophage inflammatory protein-1 alpha production namespace: biological_process def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL3 production" EXACT [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv] synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:24:17Z [Term] id: GO:0071609 name: chemokine (C-C motif) ligand 5 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL5 production" EXACT [GOC:add, GOC:rv] synonym: "RANTES production" EXACT [GOC:bf] synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:32:35Z [Term] id: GO:0071610 name: chemokine (C-C motif) ligand 1 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "CCL1 production" EXACT [GOC:add, GOC:rv] synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv] synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:35:00Z [Term] id: GO:0071611 name: granulocyte colony-stimulating factor production namespace: biological_process def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add] synonym: "CSF3 production" EXACT [GOC:add] synonym: "filgrastim production" EXACT [GOC:add] synonym: "G-CSF production" EXACT [GOC:add] synonym: "granulocyte colony stimulating factor production" EXACT [] synonym: "lenograstim production" EXACT [GOC:add] synonym: "pluripoietin production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production created_by: midori creation_date: 2010-02-05T04:38:11Z [Term] id: GO:0071612 name: IP-10 production namespace: biological_process def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv] synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-02-05T04:43:56Z [Term] id: GO:0071613 name: granzyme B production namespace: biological_process def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: midori creation_date: 2010-02-05T04:47:15Z [Term] id: GO:0071614 name: linoleic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099] synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: midori creation_date: 2010-02-05T06:05:22Z [Term] id: GO:0071615 name: oxidative deethylation namespace: biological_process def: "The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0055114 ! oxidation-reduction process created_by: midori creation_date: 2010-02-05T06:11:41Z [Term] id: GO:0071616 name: acyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] synonym: "acyl-CoA anabolism" EXACT [GOC:mah] synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah] synonym: "acyl-CoA formation" EXACT [GOC:mah] synonym: "acyl-CoA synthesis" EXACT [GOC:mah] is_a: GO:0006637 ! acyl-CoA metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process is_a: GO:0035384 ! thioester biosynthetic process is_a: GO:0043604 ! amide biosynthetic process created_by: midori creation_date: 2010-02-08T04:43:31Z [Term] id: GO:0071617 name: lysophospholipid acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: midori creation_date: 2010-02-08T04:53:37Z [Term] id: GO:0071618 name: lysophosphatidylethanolamine acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk] is_a: GO:0071617 ! lysophospholipid acyltransferase activity created_by: midori creation_date: 2010-02-08T04:59:07Z [Term] id: GO:0071619 name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: midori creation_date: 2010-02-09T02:37:02Z [Term] id: GO:0071620 name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: midori creation_date: 2010-02-09T02:39:52Z [Term] id: GO:0071621 name: granulocyte chemotaxis namespace: biological_process def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097530 ! granulocyte migration created_by: midori creation_date: 2010-02-09T04:08:17Z [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071621 ! granulocyte chemotaxis relationship: regulates GO:0071621 ! granulocyte chemotaxis created_by: midori creation_date: 2010-02-09T04:09:24Z [Term] id: GO:0071623 name: negative regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071621 ! granulocyte chemotaxis relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis created_by: midori creation_date: 2010-02-09T04:13:19Z [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071621 ! granulocyte chemotaxis relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis created_by: midori creation_date: 2010-02-09T04:15:36Z [Term] id: GO:0071625 name: vocalization behavior namespace: biological_process def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah] synonym: "vocalisation behaviour" EXACT [GOC:mah] is_a: GO:0007610 ! behavior created_by: midori creation_date: 2010-02-10T11:02:58Z [Term] id: GO:0071626 name: mastication namespace: biological_process def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] synonym: "chewing" EXACT [GOC:mah] is_a: GO:0022600 ! digestive system process created_by: midori creation_date: 2010-02-10T11:19:48Z [Term] id: GO:0071627 name: integral component of fungal-type vacuolar membrane namespace: cellular_component def: "The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to fungal-type vacuolar membrane" NARROW [] is_a: GO:0031166 ! integral component of vacuolar membrane is_a: GO:0071628 ! intrinsic component of fungal-type vacuolar membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane created_by: midori creation_date: 2010-02-10T03:45:23Z [Term] id: GO:0071628 name: intrinsic component of fungal-type vacuolar membrane namespace: cellular_component def: "The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] is_a: GO:0031310 ! intrinsic component of vacuolar membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane relationship: part_of GO:0000329 ! fungal-type vacuole membrane created_by: midori creation_date: 2010-02-10T03:53:00Z [Term] id: GO:0071629 name: cytoplasm protein quality control by the ubiquitin-proteasome system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] synonym: "ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome" EXACT [] is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: part_of GO:0071218 ! cellular response to misfolded protein created_by: midori creation_date: 2010-02-11T03:06:57Z [Term] id: GO:0071630 name: nuclear protein quality control by the ubiquitin-proteasome system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635, PMID:21211726, PMID:21324894] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] synonym: "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome" EXACT [] is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: part_of GO:0071218 ! cellular response to misfolded protein created_by: midori creation_date: 2010-02-11T03:31:46Z [Term] id: GO:0071631 name: mating pheromone secretion involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that positively regulates a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] synonym: "mating-type pheromone secretion involved in conjugation with cellular fusion" EXACT [GOC:vw] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0071834 ! mating pheromone secretion intersection_of: GO:0071834 ! mating pheromone secretion intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-02-11T03:36:57Z [Term] id: GO:0071632 name: optomotor response namespace: biological_process def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] xref: Wikipedia:Optomotor_response is_a: GO:0007634 ! optokinetic behavior created_by: midori creation_date: 2010-02-11T04:06:41Z [Term] id: GO:0071633 name: dihydroceramidase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! N-acylsphingosine amidohydrolase activity created_by: midori creation_date: 2010-02-11T04:24:12Z [Term] id: GO:0071634 name: regulation of transforming growth factor beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "regulation of TGF-B production" EXACT [GOC:mah] synonym: "regulation of TGF-beta production" EXACT [GOC:mah] synonym: "regulation of TGFB production" EXACT [GOC:mah] synonym: "regulation of transforming growth factor-beta production" EXACT [GOC:bf] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071604 ! transforming growth factor beta production relationship: regulates GO:0071604 ! transforming growth factor beta production created_by: midori creation_date: 2010-02-12T10:33:07Z [Term] id: GO:0071635 name: negative regulation of transforming growth factor beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "negative regulation of TGF-B production" EXACT [GOC:mah] synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah] synonym: "negative regulation of TGFB production" EXACT [GOC:mah] synonym: "negative regulation of transforming growth factor-beta production" EXACT [GOC:bf] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071604 ! transforming growth factor beta production relationship: negatively_regulates GO:0071604 ! transforming growth factor beta production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071636 name: positive regulation of transforming growth factor beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] synonym: "positive regulation of TGF-B production" EXACT [GOC:mah] synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah] synonym: "positive regulation of TGFB production" EXACT [GOC:mah] synonym: "positive regulation of transforming growth factor-beta production" EXACT [GOC:bf] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071604 ! transforming growth factor beta production relationship: positively_regulates GO:0071604 ! transforming growth factor beta production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071637 name: regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "regulation of CCL2 production" EXACT [GOC:mah] synonym: "regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071605 ! monocyte chemotactic protein-1 production relationship: regulates GO:0071605 ! monocyte chemotactic protein-1 production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071638 name: negative regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "negative regulation of CCL2 production" EXACT [GOC:mah] synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production relationship: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071639 name: positive regulation of monocyte chemotactic protein-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] synonym: "positive regulation of CCL2 production" EXACT [GOC:mah] synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production relationship: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071640 name: regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "regulation of CCL3 production" EXACT [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071641 name: negative regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "negative regulation of CCL3 production" EXACT [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071642 name: positive regulation of macrophage inflammatory protein 1 alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] synonym: "positive regulation of CCL3 production" EXACT [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071643 name: regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "regulation of CCL4 production" EXACT [GOC:mah] synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production created_by: midori creation_date: 2010-02-12T10:39:51Z [Term] id: GO:0071644 name: negative regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "negative regulation of CCL4 production" EXACT [GOC:mah] synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071645 name: positive regulation of chemokine (C-C motif) ligand 4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] synonym: "positive regulation of CCL4 production" EXACT [GOC:mah] synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071646 name: regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "regulation of CCL9 production" EXACT [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071647 name: negative regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "negative regulation of CCL9 production" EXACT [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071648 name: positive regulation of macrophage inflammatory protein-1 gamma production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] synonym: "positive regulation of CCL9 production" EXACT [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071649 name: regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "regulation of CCL5 production" EXACT [GOC:mah] synonym: "regulation of RANTES production" EXACT [GOC:bf] synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production relationship: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071650 name: negative regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "negative regulation of CCL5 production" EXACT [GOC:mah] synonym: "negative regulation of RANTES production" EXACT [GOC:bf] synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production relationship: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071651 name: positive regulation of chemokine (C-C motif) ligand 5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] synonym: "positive regulation of CCL5 production" EXACT [GOC:mah] synonym: "positive regulation of RANTES production" EXACT [GOC:bf] synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production relationship: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071652 name: regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "regulation of CCL1 production" EXACT [GOC:mah] synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production created_by: midori creation_date: 2010-02-12T10:40:19Z [Term] id: GO:0071653 name: negative regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "negative regulation of CCL1 production" EXACT [GOC:mah] synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071654 name: positive regulation of chemokine (C-C motif) ligand 1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] synonym: "positive regulation of CCL1 production" EXACT [GOC:mah] synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah] synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071655 name: regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "regulation of CSF3 production" EXACT [GOC:mah] synonym: "regulation of filgrastim production" EXACT [GOC:mah] synonym: "regulation of G-CSF production" EXACT [GOC:mah] synonym: "regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "regulation of lenograstim production" EXACT [GOC:mah] synonym: "regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071611 ! granulocyte colony-stimulating factor production relationship: regulates GO:0071611 ! granulocyte colony-stimulating factor production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071656 name: negative regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah] synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "negative regulation of CSF3 production" EXACT [GOC:mah] synonym: "negative regulation of filgrastim production" EXACT [GOC:mah] synonym: "negative regulation of G-CSF production" EXACT [GOC:mah] synonym: "negative regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "negative regulation of lenograstim production" EXACT [GOC:mah] synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production is_a: GO:1901257 ! negative regulation of macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production relationship: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071657 name: positive regulation of granulocyte colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] synonym: "positive regulation of CSF3 production" EXACT [GOC:mah] synonym: "positive regulation of filgrastim production" EXACT [GOC:mah] synonym: "positive regulation of G-CSF production" EXACT [GOC:mah] synonym: "positive regulation of granulocyte colony stimulating factor production" EXACT [] synonym: "positive regulation of lenograstim production" EXACT [GOC:mah] synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah] is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production is_a: GO:1901258 ! positive regulation of macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production relationship: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071658 name: regulation of IP-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071612 ! IP-10 production relationship: regulates GO:0071612 ! IP-10 production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071659 name: negative regulation of IP-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0071658 ! regulation of IP-10 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071612 ! IP-10 production relationship: negatively_regulates GO:0071612 ! IP-10 production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071660 name: positive regulation of IP-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah] synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0071658 ! regulation of IP-10 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071612 ! IP-10 production relationship: positively_regulates GO:0071612 ! IP-10 production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071661 name: regulation of granzyme B production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071613 ! granzyme B production relationship: regulates GO:0071613 ! granzyme B production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071662 name: negative regulation of granzyme B production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0071661 ! regulation of granzyme B production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071613 ! granzyme B production relationship: negatively_regulates GO:0071613 ! granzyme B production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071663 name: positive regulation of granzyme B production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0071661 ! regulation of granzyme B production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071613 ! granzyme B production relationship: positively_regulates GO:0071613 ! granzyme B production created_by: midori creation_date: 2010-02-12T10:41:14Z [Term] id: GO:0071664 name: catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054] synonym: "catenin-TCF4 complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: midori creation_date: 2010-02-12T03:19:16Z [Term] id: GO:0071665 name: gamma-catenin-TCF7L2 complex namespace: cellular_component def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah] synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054] is_a: GO:0071664 ! catenin-TCF7L2 complex created_by: midori creation_date: 2010-02-12T03:23:08Z [Term] id: GO:0071666 name: Slit-Robo signaling complex namespace: cellular_component def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766] synonym: "Slit-Robo signalling complex" EXACT [GOC:mah] is_a: GO:0032992 ! protein-carbohydrate complex created_by: midori creation_date: 2010-02-12T03:35:28Z [Term] id: GO:0071667 name: DNA/RNA hybrid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA/DNA hybrid." [GOC:ecd] synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd] is_a: GO:0003676 ! nucleic acid binding created_by: midori creation_date: 2010-02-15T01:51:44Z [Term] id: GO:0071668 name: plant-type cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah] synonym: "plant cell wall assembly" NARROW [] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0009832 ! plant-type cell wall biogenesis created_by: midori creation_date: 2010-02-15T02:19:39Z [Term] id: GO:0071669 name: plant-type cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah] synonym: "plant-type cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071554 ! cell wall organization or biogenesis created_by: midori creation_date: 2010-02-15T02:32:10Z [Term] id: GO:0071670 name: smooth muscle cell chemotaxis namespace: biological_process def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah] is_a: GO:0014909 ! smooth muscle cell migration is_a: GO:0060326 ! cell chemotaxis created_by: midori creation_date: 2010-02-16T01:32:59Z [Term] id: GO:0071671 name: regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071670 ! smooth muscle cell chemotaxis relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis created_by: midori creation_date: 2010-02-16T01:42:03Z [Term] id: GO:0071672 name: negative regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis created_by: midori creation_date: 2010-02-16T01:44:28Z [Term] id: GO:0071673 name: positive regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis created_by: midori creation_date: 2010-02-16T01:48:14Z [Term] id: GO:0071674 name: mononuclear cell migration namespace: biological_process def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0050900 ! leukocyte migration created_by: midori creation_date: 2010-02-16T02:11:00Z [Term] id: GO:0071675 name: regulation of mononuclear cell migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071674 ! mononuclear cell migration relationship: regulates GO:0071674 ! mononuclear cell migration created_by: midori creation_date: 2010-02-16T02:11:53Z [Term] id: GO:0071676 name: negative regulation of mononuclear cell migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071674 ! mononuclear cell migration relationship: negatively_regulates GO:0071674 ! mononuclear cell migration created_by: midori creation_date: 2010-02-16T02:13:55Z [Term] id: GO:0071677 name: positive regulation of mononuclear cell migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "activation of mononuclear cell migration" NARROW [GOC:mah] synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah] synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071674 ! mononuclear cell migration relationship: positively_regulates GO:0071674 ! mononuclear cell migration created_by: midori creation_date: 2010-02-16T02:15:29Z [Term] id: GO:0071678 name: olfactory bulb axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk] is_a: GO:0007411 ! axon guidance created_by: midori creation_date: 2010-02-17T02:09:34Z [Term] id: GO:0071679 name: commissural neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk] is_a: GO:0007411 ! axon guidance created_by: midori creation_date: 2010-02-17T02:21:36Z [Term] id: GO:0071680 name: response to indole-3-methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah, GOC:yaf] synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent created_by: midori creation_date: 2010-02-18T04:05:09Z [Term] id: GO:0071681 name: cellular response to indole-3-methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [CHEBI:24814, GOC:mah, GOC:yaf] synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0071680 ! response to indole-3-methanol is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2010-02-18T04:05:29Z [Term] id: GO:0071682 name: endocytic vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0030139 ! endocytic vesicle relationship: part_of GO:0030139 ! endocytic vesicle created_by: midori creation_date: 2010-02-18T04:21:53Z [Term] id: GO:0071683 name: sensory dendrite namespace: cellular_component def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] is_a: GO:0030425 ! dendrite created_by: midori creation_date: 2010-02-19T04:17:05Z [Term] id: GO:0071684 name: organism emergence from protective structure namespace: biological_process def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah] is_a: GO:0032501 ! multicellular organismal process created_by: midori creation_date: 2010-02-19T04:23:55Z [Term] id: GO:0071685 name: NADH dehydrogenase complex (plastoquinone) namespace: cellular_component def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah] is_a: GO:0010598 ! NAD(P)H dehydrogenase complex (plastoquinone) is_a: GO:0030964 ! NADH dehydrogenase complex relationship: part_of GO:0031976 ! plastid thylakoid created_by: midori creation_date: 2010-02-19T05:20:45Z [Term] id: GO:0071686 name: obsolete horsetail nucleus namespace: cellular_component def: "OBSOLETE. The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757] comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions. is_obsolete: true created_by: midori creation_date: 2010-02-22T04:52:01Z [Term] id: GO:0071687 name: obsolete horsetail nucleus leading edge namespace: cellular_component def: "OBSOLETE. The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757] comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions. is_obsolete: true created_by: midori creation_date: 2010-02-22T05:04:40Z [Term] id: GO:0071688 name: striated muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031034 ! myosin filament assembly relationship: part_of GO:0030239 ! myofibril assembly created_by: midori creation_date: 2010-02-25T03:52:21Z [Term] id: GO:0071689 name: muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0030239 ! myofibril assembly created_by: midori creation_date: 2010-02-25T03:54:06Z [Term] id: GO:0071690 name: cardiac muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah] is_a: GO:0071688 ! striated muscle myosin thick filament assembly relationship: part_of GO:0055003 ! cardiac myofibril assembly created_by: midori creation_date: 2010-02-25T03:55:44Z [Term] id: GO:0071691 name: cardiac muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0055003 ! cardiac myofibril assembly created_by: midori creation_date: 2010-02-25T03:57:01Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: GO:0008104 ! protein localization created_by: midori creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071693 name: protein transport within extracellular region namespace: biological_process def: "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015031 ! protein transport is_a: GO:0035592 ! establishment of protein localization to extracellular region created_by: midori creation_date: 2010-02-25T04:02:35Z [Term] id: GO:0071694 name: maintenance of protein location in extracellular region namespace: biological_process def: "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0045185 ! maintenance of protein location relationship: part_of GO:0071692 ! protein localization to extracellular region created_by: midori creation_date: 2010-02-25T04:04:41Z [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0048856 ! anatomical structure development created_by: midori creation_date: 2010-03-02T11:43:38Z [Term] id: GO:0071696 name: ectodermal placode development namespace: biological_process def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0048856 ! anatomical structure development created_by: midori creation_date: 2010-03-02T11:48:01Z [Term] id: GO:0071697 name: ectodermal placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0071696 ! ectodermal placode development created_by: midori creation_date: 2010-03-02T11:49:51Z [Term] id: GO:0071698 name: olfactory placode development namespace: biological_process def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071696 ! ectodermal placode development created_by: midori creation_date: 2010-03-02T12:45:14Z [Term] id: GO:0071699 name: olfactory placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0071697 ! ectodermal placode morphogenesis relationship: part_of GO:0071698 ! olfactory placode development created_by: midori creation_date: 2010-03-02T12:45:45Z [Term] id: GO:0071700 name: olfactory placode maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0071698 ! olfactory placode development created_by: midori creation_date: 2010-03-02T01:10:54Z [Term] id: GO:0071701 name: regulation of MAPK export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:dgf] synonym: "regulation of cytoplasmic translocation of MAP kinase" EXACT [GOC:mah] synonym: "regulation of cytoplasmic translocation of mitogen-activated protein kinase" EXACT [GOC:mah] synonym: "regulation of MAPK export from cell nucleus" EXACT [GOC:mah] synonym: "regulation of MAPK export out of nucleus" EXACT [GOC:mah] synonym: "regulation of MAPK transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "regulation of MAPK-nucleus export" EXACT [GOC:mah] is_a: GO:0046825 ! regulation of protein export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045204 ! MAPK export from nucleus relationship: regulates GO:0045204 ! MAPK export from nucleus created_by: midori creation_date: 2010-03-02T01:24:12Z [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [CHEBI:50860, GOC:mah] is_a: GO:0006810 ! transport created_by: midori creation_date: 2010-03-08T02:15:14Z [Term] id: GO:0071703 name: detection of organic substance namespace: biological_process def: "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010033 ! response to organic substance created_by: midori creation_date: 2010-03-08T03:18:44Z [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [CHEBI:50860, GOC:mah] synonym: "organic molecular entity metabolic process" EXACT [] synonym: "organic molecular entity metabolism" EXACT [] synonym: "organic substance metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: midori creation_date: 2010-03-08T03:32:18Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:51143, GOC:mah] is_a: GO:0006810 ! transport created_by: midori creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071706 name: tumor necrosis factor superfamily cytokine production namespace: biological_process def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] synonym: "TNF superfamily production" RELATED [GOC:rv] synonym: "TNFSF cytokine production" EXACT [GOC:add] is_a: GO:0001816 ! cytokine production created_by: midori creation_date: 2010-03-09T02:40:35Z [Term] id: GO:0071707 name: immunoglobulin heavy chain V-D-J recombination namespace: biological_process def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination created_by: midori creation_date: 2010-03-09T04:20:31Z [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination namespace: biological_process def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] synonym: "immunoglobulin V-J joining" EXACT [GOC:add] is_a: GO:0033152 ! immunoglobulin V(D)J recombination created_by: midori creation_date: 2010-03-09T04:22:29Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061024 ! membrane organization relationship: part_of GO:0044091 ! membrane biogenesis created_by: midori creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071710 name: membrane macromolecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell." [GOC:mah] synonym: "membrane macromolecule anabolism" EXACT [GOC:mah] synonym: "membrane macromolecule biosynthesis" EXACT [GOC:mah] synonym: "membrane macromolecule formation" EXACT [GOC:mah] synonym: "membrane macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0070589 ! cellular component macromolecule biosynthetic process relationship: part_of GO:0044091 ! membrane biogenesis created_by: midori creation_date: 2010-03-10T11:29:52Z [Term] id: GO:0071711 name: basement membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. synonym: "basement membrane organisation" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization created_by: midori creation_date: 2010-03-10T11:57:10Z [Term] id: GO:0071712 name: ER-associated misfolded protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:vw, PMID:14607247, PMID:19520858] comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "endoplasmic reticulum-associated misfolded protein catabolic process" EXACT [GOC:mah] synonym: "endoplasmic reticulum-associated misfolded protein catabolism" EXACT [GOC:mah] synonym: "ER-associated misfolded protein breakdown" EXACT [GOC:mah] synonym: "ER-associated misfolded protein catabolism" EXACT [GOC:mah] synonym: "ER-associated misfolded protein degradation" EXACT [GOC:mah] synonym: "proteasomal protein catabolism of misfolded ER proteins" EXACT [GOC:bf] is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins is_a: GO:0036503 ! ERAD pathway relationship: part_of GO:0071218 ! cellular response to misfolded protein created_by: midori creation_date: 2010-03-10T12:53:27Z [Term] id: GO:0071713 name: para-aminobenzoyl-glutamate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate." [GOC:imk, PMID:20190044] is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: midori creation_date: 2010-03-10T01:25:31Z [Term] id: GO:0071714 name: icosanoid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of icosanoids from one side of a membrane to the other." [GOC:sl] synonym: "eicosanoid transmembrane transporter activity" EXACT [GOC:sl] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0071715 ! icosanoid transport created_by: midori creation_date: 2010-03-10T01:50:08Z [Term] id: GO:0071715 name: icosanoid transport namespace: biological_process def: "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah] synonym: "eicosanoid transport" EXACT [GOC:sl] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901571 ! fatty acid derivative transport created_by: midori creation_date: 2010-03-10T02:47:22Z [Term] id: GO:0071716 name: leukotriene transport namespace: biological_process def: "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah] is_a: GO:0071715 ! icosanoid transport created_by: midori creation_date: 2010-03-10T02:53:59Z [Term] id: GO:0071717 name: thromboxane transport namespace: biological_process def: "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah] is_a: GO:0015908 ! fatty acid transport is_a: GO:0071715 ! icosanoid transport created_by: midori creation_date: 2010-03-10T03:03:49Z [Term] id: GO:0071718 name: sodium-independent icosanoid transport namespace: biological_process def: "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [CHEBI:23899, GOC:mah, GOC:sl] synonym: "sodium-independent eicosanoid transport" EXACT [GOC:sl] is_a: GO:0071715 ! icosanoid transport created_by: midori creation_date: 2010-03-10T03:05:13Z [Term] id: GO:0071719 name: sodium-independent leukotriene transport namespace: biological_process def: "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [CHEBI:25029, GOC:mah] is_a: GO:0071716 ! leukotriene transport is_a: GO:0071718 ! sodium-independent icosanoid transport created_by: midori creation_date: 2010-03-10T03:08:42Z [Term] id: GO:0071720 name: sodium-independent prostaglandin transport namespace: biological_process def: "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015732 ! prostaglandin transport is_a: GO:0071718 ! sodium-independent icosanoid transport created_by: midori creation_date: 2010-03-10T03:09:10Z [Term] id: GO:0071721 name: sodium-independent thromboxane transport namespace: biological_process def: "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [CHEBI:26995, GOC:mah] is_a: GO:0071717 ! thromboxane transport is_a: GO:0071718 ! sodium-independent icosanoid transport created_by: midori creation_date: 2010-03-10T03:10:45Z [Term] id: GO:0071722 name: detoxification of arsenic-containing substance namespace: biological_process def: "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439] synonym: "detoxification of arsenic" EXACT [] is_a: GO:0098754 ! detoxification relationship: part_of GO:0046685 ! response to arsenic-containing substance created_by: midori creation_date: 2010-03-17T01:35:56Z [Term] id: GO:0071723 name: lipopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "bacterial lipopeptide binding" NARROW [GOC:add] synonym: "bacterial lipoprotein binding" RELATED [GOC:add] is_a: GO:0008289 ! lipid binding is_a: GO:0042277 ! peptide binding created_by: midori creation_date: 2010-03-17T02:13:21Z [Term] id: GO:0071724 name: response to diacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "response to diacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0070339 ! response to bacterial lipopeptide created_by: midori creation_date: 2010-03-17T02:14:41Z [Term] id: GO:0071725 name: response to triacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "response to triacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0070339 ! response to bacterial lipopeptide created_by: midori creation_date: 2010-03-17T02:16:40Z [Term] id: GO:0071726 name: cellular response to diacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "cellular response to diacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0071221 ! cellular response to bacterial lipopeptide is_a: GO:0071724 ! response to diacyl bacterial lipopeptide created_by: midori creation_date: 2010-03-17T02:17:02Z [Term] id: GO:0071727 name: cellular response to triacyl bacterial lipopeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. synonym: "cellular response to triacylated bacterial lipoprotein" EXACT [GOC:add] is_a: GO:0071221 ! cellular response to bacterial lipopeptide is_a: GO:0071725 ! response to triacyl bacterial lipopeptide created_by: midori creation_date: 2010-03-17T02:17:49Z [Term] id: GO:0071728 name: beak development namespace: biological_process def: "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development created_by: midori creation_date: 2010-03-17T03:52:48Z [Term] id: GO:0071729 name: beak morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0071728 ! beak development created_by: midori creation_date: 2010-03-17T03:54:34Z [Term] id: GO:0071730 name: beak formation namespace: biological_process def: "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0071729 ! beak morphogenesis created_by: midori creation_date: 2010-03-17T03:57:07Z [Term] id: GO:0071731 name: response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance is_a: GO:0097366 ! response to bronchodilator is_a: GO:1901698 ! response to nitrogen compound created_by: midori creation_date: 2010-03-17T04:03:38Z [Term] id: GO:0071732 name: cellular response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0071731 ! response to nitric oxide is_a: GO:1902170 ! cellular response to reactive nitrogen species created_by: midori creation_date: 2010-03-17T04:12:52Z [Term] id: GO:0071733 name: transcriptional activation by promoter-enhancer looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429] synonym: "long-range enhancer-promoter communication" RELATED [PMID:15060134] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0090202 ! gene looping created_by: midori creation_date: 2010-03-19T02:01:19Z [Term] id: GO:0071734 name: biotin-[pyruvate-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)." [GOC:mah, PMID:10551847] synonym: "biotin-[pyruvate carboxylase] ligase activity" EXACT [GOC:jp] synonym: "biotin-[pyruvate carboxylase] synthetase activity" EXACT [GOC:mah] synonym: "biotin-pyruvate carboxylase synthetase activity" EXACT [GOC:mah] synonym: "biotin-pyruvate-carboxylase ligase activity" EXACT [GOC:mah] synonym: "biotin:apo-pyruvate-carboxylase ligase" EXACT [GOC:mah] xref: EC:6.3.4 is_a: GO:0018271 ! biotin-protein ligase activity created_by: midori creation_date: 2010-03-19T02:37:24Z [Term] id: GO:0071735 name: IgG immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG1" NARROW [GOC:add] synonym: "IgG2" NARROW [GOC:add] synonym: "IgG2a" NARROW [GOC:add] synonym: "IgG2b" NARROW [GOC:add] synonym: "IgG2c" NARROW [GOC:add] synonym: "IgG3" NARROW [GOC:add] synonym: "IgG4" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071736 name: IgG immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "IgG antibody" NARROW [GOC:add] synonym: "IgG1 antibody" NARROW [GOC:add] synonym: "IgG2 antibody" NARROW [GOC:add] synonym: "IgG2a antibody" NARROW [GOC:add] synonym: "IgG2b antibody" NARROW [GOC:add] synonym: "IgG2c antibody" NARROW [GOC:add] synonym: "IgG3 antibody" NARROW [GOC:add] synonym: "IgG4 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071735 ! IgG immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071737 name: IgG B cell receptor complex namespace: cellular_component def: "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. synonym: "membrane-bound IgG" NARROW [GOC:add] synonym: "membrane-bound IgG1" NARROW [GOC:add] synonym: "membrane-bound IgG2" NARROW [GOC:add] synonym: "membrane-bound IgG2a" NARROW [GOC:add] synonym: "membrane-bound IgG2b" NARROW [GOC:add] synonym: "membrane-bound IgG2c" NARROW [GOC:add] synonym: "membrane-bound IgG3" NARROW [GOC:add] synonym: "membrane-bound IgG4" NARROW [GOC:add] synonym: "surface IgG" NARROW [GOC:add] synonym: "surface IgG1" NARROW [GOC:add] synonym: "surface IgG2" NARROW [GOC:add] synonym: "surface IgG2a" NARROW [GOC:add] synonym: "surface IgG2b" NARROW [GOC:add] synonym: "surface IgG2c" NARROW [GOC:add] synonym: "surface IgG3" NARROW [GOC:add] synonym: "surface IgG4" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071735 ! IgG immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071738 name: IgD immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071739 name: IgD immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgD antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071738 ! IgD immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071740 name: IgD B cell receptor complex namespace: cellular_component def: "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgD" EXACT [GOC:add] synonym: "surface IgD" EXACT [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071738 ! IgD immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071741 name: IgD immunoglobulin complex, GPI-anchored namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392] comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "GPI-anchored IgD" EXACT [GOC:add] is_a: GO:0071738 ! IgD immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071742 name: IgE immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071743 name: IgE immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgE antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071742 ! IgE immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071744 name: IgE B cell receptor complex namespace: cellular_component def: "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgE" EXACT [GOC:add] synonym: "surface IgE" EXACT [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071742 ! IgE immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071745 name: IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071746 name: IgA immunoglobulin complex, circulating namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgA antibody" EXACT [GOC:add] synonym: "IgA1 antibody" NARROW [GOC:add] synonym: "IgA2 antibody" NARROW [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071745 ! IgA immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071747 name: IgA B cell receptor complex namespace: cellular_component def: "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgA" NARROW [GOC:add] synonym: "membrane-bound IgA1" NARROW [GOC:add] synonym: "membrane-bound IgA2" NARROW [GOC:add] synonym: "surface IgA" NARROW [GOC:add] synonym: "surface IgA1" NARROW [GOC:add] synonym: "surface IgA2" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071745 ! IgA immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071748 name: monomeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "monomeric IgA antibody" EXACT [GOC:add] synonym: "monomeric IgA1 antibody" NARROW [GOC:add] synonym: "monomeric IgA2 antibody" NARROW [GOC:add] is_a: GO:0071746 ! IgA immunoglobulin complex, circulating created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071749 name: polymeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms. synonym: "pIgA antibody" EXACT [GOC:add] synonym: "pIgA1 antibody" NARROW [GOC:add] synonym: "polymeric IgA antibody" EXACT [GOC:add] synonym: "polymeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071746 ! IgA immunoglobulin complex, circulating created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071750 name: dimeric IgA immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. synonym: "dimeric IgA antibody" EXACT [GOC:add] synonym: "dimeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071749 ! polymeric IgA immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071751 name: secretory IgA immunoglobulin complex namespace: cellular_component def: "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA. synonym: "secretory IgA antibody" EXACT [GOC:add] synonym: "sIgA antibody" EXACT [GOC:add] synonym: "sIgA1 antibody" NARROW [GOC:add] is_a: GO:0071749 ! polymeric IgA immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071752 name: secretory dimeric IgA immunoglobulin complex namespace: cellular_component def: "A dimeric form of secretory IgA immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985] comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. synonym: "secretory dimeric IgA antibody" EXACT [GOC:add] synonym: "secretory dimeric IgA1 antibody" NARROW [GOC:add] is_a: GO:0071750 ! dimeric IgA immunoglobulin complex is_a: GO:0071751 ! secretory IgA immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071753 name: IgM immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071754 name: IgM immunoglobulin complex, circulating namespace: cellular_component def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "IgM antibody" EXACT [GOC:add] is_a: GO:0042571 ! immunoglobulin complex, circulating is_a: GO:0071753 ! IgM immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071755 name: IgM B cell receptor complex namespace: cellular_component def: "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "membrane-bound IgM" NARROW [GOC:add] synonym: "surface IgM" NARROW [GOC:add] is_a: GO:0019815 ! B cell receptor complex is_a: GO:0071753 ! IgM immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071756 name: pentameric IgM immunoglobulin complex namespace: cellular_component def: "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "pentameric IgM antibody" EXACT [GOC:add] is_a: GO:0071754 ! IgM immunoglobulin complex, circulating created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071757 name: hexameric IgM immunoglobulin complex namespace: cellular_component def: "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "hexameric IgM antibody" EXACT [GOC:add] is_a: GO:0071754 ! IgM immunoglobulin complex, circulating created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071758 name: IgW immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071759 name: IgX immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071760 name: IgY immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] comment: Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds. is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071761 name: IgZ immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish." [GOC:add, ISBN:0781765196] comment: Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout. synonym: "IgT antibody" NARROW [GOC:add] synonym: "IgT immunoglobulin complex" EXACT [ISBN:0781765196] synonym: "IgZ antibody" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071762 name: heavy chain immunoglobulin complex namespace: cellular_component def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains." [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357] comment: Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains. synonym: "HCab" NARROW [GOC:add] synonym: "Ig NAR immunoglobulin complex" NARROW [GOC:add] synonym: "IgNAR antibody" NARROW [GOC:add] synonym: "IgNAR immunoglobulin complex" NARROW [GOC:add] is_a: GO:0019814 ! immunoglobulin complex created_by: midori creation_date: 2010-03-24T01:44:53Z [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0006998 ! nuclear envelope organization created_by: midori creation_date: 2010-03-29T03:59:35Z [Term] id: GO:0071764 name: nuclear outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization created_by: midori creation_date: 2010-03-29T04:03:37Z [Term] id: GO:0071765 name: nuclear inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane." [GOC:mah] synonym: "nuclear inner membrane organisation" EXACT [GOC:mah] synonym: "nuclear inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization created_by: midori creation_date: 2010-03-29T04:04:57Z [Term] id: GO:0071766 name: Actinobacterium-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface." [GOC:mah, PMID:15653820, PMID:3149973] is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis created_by: midori creation_date: 2010-03-29T04:12:51Z [Term] id: GO:0071767 name: mycolic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, PMID:15653820] synonym: "mycolate metabolic process" EXACT [GOC:mah] synonym: "mycolic acid metabolism" EXACT [GOC:mah] is_a: GO:0006631 ! fatty acid metabolic process created_by: midori creation_date: 2010-03-29T04:33:31Z [Term] id: GO:0071768 name: mycolic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, MetaCyc:PWYG-321, PMID:15653820] synonym: "mycolate biosynthetic process" EXACT [GOC:mah] synonym: "mycolic acid anabolism" EXACT [GOC:mah] synonym: "mycolic acid biosynthesis" EXACT [GOC:mah] synonym: "mycolic acid formation" EXACT [GOC:mah] synonym: "mycolic acid synthesis" EXACT [GOC:mah] xref: MetaCyc:PWYG-321 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0071767 ! mycolic acid metabolic process relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis created_by: midori creation_date: 2010-03-29T04:36:10Z [Term] id: GO:0071769 name: mycolate cell wall layer assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer." [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973] synonym: "mycolate cell wall layer biogenesis" RELATED [GOC:mah] xref: MetaCyc:PWY-6397 is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis created_by: midori creation_date: 2010-03-29T04:40:45Z [Term] id: GO:0071770 name: DIM/DIP cell wall layer assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall." [GOC:mah, GOC:pr, PMID:15653820, PMID:3149973] synonym: "DIM cell wall layer assembly" EXACT [GOC:mah] synonym: "DIM/DIP cell wall layer biogenesis" RELATED [GOC:mah] synonym: "PDIM cell wall layer assembly" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis created_by: midori creation_date: 2010-03-29T04:47:19Z [Term] id: GO:0071771 name: aldehyde decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO." [GOC:kad, PMID:6593720, PMID:8718622] synonym: "decarbonylase activity" EXACT [GOC:kad, GOC:mah] is_a: GO:0016830 ! carbon-carbon lyase activity created_by: midori creation_date: 2010-04-01T12:02:50Z [Term] id: GO:0071772 name: response to BMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] synonym: "response to BMP stimulus" EXACT [GOC:dos] synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: midori creation_date: 2010-08-31T11:02:11Z [Term] id: GO:0071773 name: cellular response to BMP stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:0071772 ! response to BMP created_by: midori creation_date: 2010-08-31T11:04:45Z [Term] id: GO:0071774 name: response to fibroblast growth factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah] synonym: "response to FGF stimulus" EXACT [GOC:mah] synonym: "response to fibroblast growth factor stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: midori creation_date: 2010-08-31T11:06:32Z [Term] id: GO:0071778 name: obsolete WINAC complex namespace: cellular_component def: "OBSOLETE. A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors." [GOC:BHF, PMID:12837248] comment: This term was made obsolete because the paper describing the characterization of this complex, which was used to create this term, has been retracted. synonym: "WINAC complex" EXACT [] is_obsolete: true created_by: midori creation_date: 2010-08-31T12:19:54Z [Term] id: GO:0071781 name: endoplasmic reticulum cisternal network namespace: cellular_component def: "A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "ER cisternal network" EXACT [GOC:mah] is_a: GO:0098827 ! endoplasmic reticulum subcompartment created_by: midori creation_date: 2010-09-01T01:29:54Z [Term] id: GO:0071782 name: endoplasmic reticulum tubular network namespace: cellular_component def: "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "ER tubular network" EXACT [GOC:mah] is_a: GO:0098827 ! endoplasmic reticulum subcompartment created_by: midori creation_date: 2010-09-01T01:32:55Z [Term] id: GO:0071783 name: endoplasmic reticulum cisternal network organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum cisternal network organisation" EXACT [GOC:mah] synonym: "ER cisternal network organisation" EXACT [GOC:mah] synonym: "ER cisternal network organization" EXACT [GOC:mah] is_a: GO:0007029 ! endoplasmic reticulum organization created_by: midori creation_date: 2010-09-01T01:47:28Z [Term] id: GO:0071784 name: endoplasmic reticulum cisternal network assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum cisternal network formation" EXACT [GOC:mah] synonym: "ER cisternal network assembly" EXACT [GOC:mah] synonym: "ER cisternal network formation" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization created_by: midori creation_date: 2010-09-01T01:50:49Z [Term] id: GO:0071785 name: endoplasmic reticulum cisternal network maintenance namespace: biological_process def: "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "ER cisternal network maintenance" EXACT [GOC:mah] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization created_by: midori creation_date: 2010-09-01T01:52:26Z [Term] id: GO:0071786 name: endoplasmic reticulum tubular network organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum tubular network organisation" EXACT [GOC:mah] synonym: "ER tubular network organisation" EXACT [GOC:mah] synonym: "ER tubular network organization" EXACT [GOC:mah] is_a: GO:0007029 ! endoplasmic reticulum organization created_by: midori creation_date: 2010-09-01T01:53:51Z [Term] id: GO:0071787 name: endoplasmic reticulum tubular network formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, GOC:vw, PMID:16469703, PMID:20434336] synonym: "endoplasmic reticulum tubular network assembly" EXACT [] synonym: "ER tubular network assembly" EXACT [GOC:mah] synonym: "ER tubular network formation" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0071786 ! endoplasmic reticulum tubular network organization created_by: midori creation_date: 2010-09-01T01:54:29Z [Term] id: GO:0071788 name: endoplasmic reticulum tubular network maintenance namespace: biological_process def: "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] synonym: "ER tubular network maintenance" EXACT [GOC:mah] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0071786 ! endoplasmic reticulum tubular network organization created_by: midori creation_date: 2010-09-01T01:55:06Z [Term] id: GO:0071789 name: spindle pole body localization to nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "spindle pole body docking" EXACT [GOC:vw] synonym: "spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] synonym: "spindle pole body localization in nuclear envelope" EXACT [] is_a: GO:0070631 ! spindle pole body localization created_by: midori creation_date: 2010-09-01T02:22:44Z [Term] id: GO:0071790 name: establishment of spindle pole body localization to nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT [] is_a: GO:0070632 ! establishment of spindle pole body localization is_a: GO:0071789 ! spindle pole body localization to nuclear envelope created_by: midori creation_date: 2010-09-01T02:25:44Z [Term] id: GO:0071791 name: chemokine (C-C motif) ligand 5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with chemokine (C-C motif) ligand 5." [GOC:add, GOC:amm] synonym: "CCL5 binding" EXACT [GOC:add, GOC:amm] synonym: "RANTES binding" EXACT [GOC:bf] synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted binding" EXACT [GOC:add] is_a: GO:0019957 ! C-C chemokine binding created_by: midori creation_date: 2010-09-01T02:28:22Z [Term] id: GO:0071792 name: bacillithiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] synonym: "bacillithiol metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0051186 ! cofactor metabolic process created_by: midori creation_date: 2010-09-02T11:13:47Z [Term] id: GO:0071793 name: bacillithiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] synonym: "bacillithiol anabolism" EXACT [GOC:mah] synonym: "bacillithiol biosynthesis" EXACT [GOC:mah] synonym: "bacillithiol formation" EXACT [GOC:mah] synonym: "bacillithiol synthesis" EXACT [GOC:mah] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0071792 ! bacillithiol metabolic process created_by: midori creation_date: 2010-09-02T11:16:04Z [Term] id: GO:0071794 name: CAP-Gly domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets." [GOC:mah, InterPro:IPR000938] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-09-02T02:02:53Z [Term] id: GO:0071795 name: K11-linked polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein." [GOC:sp, PMID:18775313] is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding created_by: midori creation_date: 2010-09-02T02:11:41Z [Term] id: GO:0071796 name: K6-linked polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein." [GOC:sp, PMID:17525341, PMID:20351172] is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding created_by: midori creation_date: 2010-09-02T02:13:07Z [Term] id: GO:0071797 name: LUBAC complex namespace: cellular_component def: "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180] is_a: GO:0000151 ! ubiquitin ligase complex created_by: midori creation_date: 2010-09-02T04:09:55Z [Term] id: GO:0071798 name: response to prostaglandin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] synonym: "response to prostaglandin D stimulus" EXACT [GOC:dos] is_a: GO:0034694 ! response to prostaglandin is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: midori creation_date: 2010-09-03T10:48:03Z [Term] id: GO:0071799 name: cellular response to prostaglandin D stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] is_a: GO:0071379 ! cellular response to prostaglandin stimulus is_a: GO:0071798 ! response to prostaglandin D is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2010-09-03T10:48:35Z [Term] id: GO:0071800 name: podosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [GOC:mah, GOC:sl] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0070925 ! organelle assembly created_by: midori creation_date: 2010-09-03T11:00:45Z [Term] id: GO:0071801 name: regulation of podosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of podosome assembly." [GOC:mah, GOC:sl] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071800 ! podosome assembly relationship: regulates GO:0071800 ! podosome assembly created_by: midori creation_date: 2010-09-03T01:34:29Z [Term] id: GO:0071802 name: negative regulation of podosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of podosome assembly." [GOC:mah, GOC:sl] synonym: "down regulation of podosome assembly" EXACT [GOC:mah] synonym: "down-regulation of podosome assembly" EXACT [GOC:mah] synonym: "downregulation of podosome assembly" EXACT [GOC:mah] synonym: "inhibition of podosome assembly" NARROW [GOC:mah] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0071801 ! regulation of podosome assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071800 ! podosome assembly relationship: negatively_regulates GO:0071800 ! podosome assembly created_by: midori creation_date: 2010-09-03T01:49:14Z [Term] id: GO:0071803 name: positive regulation of podosome assembly namespace: biological_process def: "Any process that activates or increases the rate or extent of podosome assembly." [GOC:mah, GOC:sl] synonym: "activation of podosome assembly" NARROW [GOC:mah] synonym: "stimulation of podosome assembly" NARROW [GOC:mah] synonym: "up regulation of podosome assembly" EXACT [GOC:mah] synonym: "up-regulation of podosome assembly" EXACT [GOC:mah] synonym: "upregulation of podosome assembly" EXACT [GOC:mah] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0071801 ! regulation of podosome assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071800 ! podosome assembly relationship: positively_regulates GO:0071800 ! podosome assembly created_by: midori creation_date: 2010-09-03T01:50:50Z [Term] id: GO:0071805 name: potassium ion transmembrane transport namespace: biological_process alt_id: GO:0010163 def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "high affinity potassium ion import" NARROW [] synonym: "high affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] synonym: "high-affinity potassium ion import" NARROW [] synonym: "high-affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] synonym: "potassium ion membrane transport" EXACT [] is_a: GO:0006813 ! potassium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: midori creation_date: 2010-09-03T02:43:49Z [Term] id: GO:0071806 name: protein transmembrane transport namespace: biological_process def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_drosophila synonym: "protein membrane transport" EXACT [] is_a: GO:0015031 ! protein transport is_a: GO:0055085 ! transmembrane transport created_by: midori creation_date: 2010-09-03T02:54:26Z [Term] id: GO:0071807 name: replication fork arrest involved in DNA replication termination namespace: biological_process def: "A replication fork arrest process that contributes to the termination of DNA replication." [GOC:mah, PMID:17347517, PMID:20797631] is_a: GO:0043111 ! replication fork arrest intersection_of: GO:0043111 ! replication fork arrest intersection_of: part_of GO:0006274 ! DNA replication termination relationship: part_of GO:0006274 ! DNA replication termination created_by: midori creation_date: 2010-09-03T03:26:38Z [Term] id: GO:0071808 name: satellite fibril namespace: cellular_component def: "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section)." [GOC:mah, GOC:sl, PMID:20108326] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005930 ! axoneme created_by: midori creation_date: 2010-09-03T03:42:14Z [Term] id: GO:0071809 name: regulation of fever generation by regulation of prostaglandin biosynthesis namespace: biological_process def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0031620 ! regulation of fever generation intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process relationship: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process created_by: midori creation_date: 2010-09-03T05:07:17Z [Term] id: GO:0071810 name: regulation of fever generation by regulation of prostaglandin secretion namespace: biological_process def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031620 ! regulation of fever generation is_a: GO:0032306 ! regulation of prostaglandin secretion intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion relationship: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion created_by: midori creation_date: 2010-09-03T05:09:27Z [Term] id: GO:0071811 name: positive regulation of fever generation by positive regulation of prostaglandin biosynthesis namespace: biological_process def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031394 ! positive regulation of prostaglandin biosynthetic process is_a: GO:0031622 ! positive regulation of fever generation intersection_of: GO:0031394 ! positive regulation of prostaglandin biosynthetic process intersection_of: positively_regulates GO:0001660 ! fever generation created_by: midori creation_date: 2010-09-03T05:10:05Z [Term] id: GO:0071812 name: positive regulation of fever generation by positive regulation of prostaglandin secretion namespace: biological_process def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah] is_a: GO:0031622 ! positive regulation of fever generation is_a: GO:0032308 ! positive regulation of prostaglandin secretion intersection_of: GO:0031622 ! positive regulation of fever generation intersection_of: positively_regulates GO:0032310 ! prostaglandin secretion created_by: midori creation_date: 2010-09-03T05:10:36Z [Term] id: GO:0071813 name: lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:BHF, GOC:mah] synonym: "lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein binding" RELATED [GOC:mah] synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah] is_a: GO:0071814 ! protein-lipid complex binding created_by: midori creation_date: 2010-09-06T03:16:01Z [Term] id: GO:0071814 name: protein-lipid complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah] is_a: GO:0044877 ! protein-containing complex binding created_by: midori creation_date: 2010-09-06T04:26:27Z [Term] id: GO:0071815 name: intermediate-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm." [GOC:BHF, GOC:mah] synonym: "IDL binding" EXACT [GOC:BHF] synonym: "intermediate-density lipoprotein binding" EXACT [GOC:dph] is_a: GO:0071813 ! lipoprotein particle binding created_by: midori creation_date: 2010-09-06T04:28:35Z [Term] id: GO:0071816 name: tail-anchored membrane protein insertion into ER membrane namespace: biological_process def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083] synonym: "protein insertion of tail-anchored membrane proteins into ER membrane" EXACT [GOC:sp] synonym: "tail-anchored membrane protein insertion into endoplasmic reticulum membrane" EXACT [GOC:mah] synonym: "type II transmembrane protein insertion into ER membrane" EXACT [GOC:mah, GOC:sp] is_a: GO:0045048 ! protein insertion into ER membrane created_by: midori creation_date: 2010-09-06T04:55:16Z [Term] id: GO:0071817 name: MMXD complex namespace: cellular_component def: "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation." [GOC:sp, PMID:20797633] synonym: "MMS19-MIP18-XPD complex" EXACT [GOC:sp, PMID:20797633] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005819 ! spindle created_by: midori creation_date: 2010-09-07T10:53:42Z [Term] id: GO:0071818 name: BAT3 complex namespace: cellular_component def: "A protein complex consisting of BAT3 (BAG6) and its cofactors. In mammals these cofactors are TRC35 (GET4) and UBL4A. It facilitates tail-anchored protein capture by ASNA1/TRC4 and also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD)." [GOC:bf, GOC:mah, GOC:sp, PMID:20676083, PMID:21636303] synonym: "Bag6 complex" EXACT [PMID:21636303] synonym: "BAG6-UBL4A-TRC35 complex" EXACT [PMID:21636303] synonym: "BAT3-TRC35-UBL4A complex" RELATED [PMID:20676083] is_a: GO:0072379 ! ER membrane insertion complex created_by: midori creation_date: 2010-09-07T11:01:38Z [Term] id: GO:0071819 name: DUBm complex namespace: cellular_component def: "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473] synonym: "deubiquitinating module" EXACT [GOC:jp, PMID:20395473] synonym: "deubiquitination module" EXACT [PMID:19226466] synonym: "SAGA DUBm complex" NARROW [GOC:jp] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2010-09-07T11:19:28Z [Term] id: GO:0071820 name: N-box binding namespace: molecular_function def: "Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses." [GOC:yaf, PMID:11498047] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "N box binding" EXACT [GOC:mah] synonym: "N-box promoter binding" EXACT [GOC:mah] is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding created_by: midori creation_date: 2010-09-07T11:55:32Z [Term] id: GO:0071821 name: FANCM-MHF complex namespace: cellular_component def: "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: midori creation_date: 2010-09-07T12:08:38Z [Term] id: GO:0071823 name: protein-carbohydrate complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." [GOC:mah] synonym: "protein-carbohydrate complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization created_by: midori creation_date: 2010-09-08T10:03:03Z [Term] id: GO:0071824 name: protein-DNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah] synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization created_by: midori creation_date: 2010-09-08T10:03:26Z [Term] id: GO:0071825 name: protein-lipid complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah] synonym: "protein-lipid complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization created_by: midori creation_date: 2010-09-08T10:04:36Z [Term] id: GO:0071826 name: ribonucleoprotein complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization created_by: midori creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071827 name: plasma lipoprotein particle organization namespace: biological_process def: "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins." [GOC:BHF, GOC:mah] synonym: "plasma lipoprotein particle organisation" EXACT [GOC:mah] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0071825 ! protein-lipid complex subunit organization created_by: midori creation_date: 2010-09-08T10:32:26Z [Term] id: GO:0071828 name: apolipoprotein E recycling namespace: biological_process def: "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle." [GOC:BHF, PMID:16373604] synonym: "APOE recycling" EXACT [GOC:BHF] is_a: GO:0015031 ! protein transport relationship: part_of GO:0034380 ! high-density lipoprotein particle assembly relationship: part_of GO:0034382 ! chylomicron remnant clearance created_by: midori creation_date: 2010-09-08T11:05:15Z [Term] id: GO:0071829 name: plasma lipoprotein particle disassembly namespace: biological_process def: "The disaggregation of a plasma lipoprotein particle into its constituent components." [GOC:mah] is_a: GO:0032987 ! protein-lipid complex disassembly is_a: GO:0071827 ! plasma lipoprotein particle organization relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels created_by: midori creation_date: 2010-09-08T11:14:21Z [Term] id: GO:0071830 name: triglyceride-rich lipoprotein particle clearance namespace: biological_process def: "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] is_a: GO:0034381 ! plasma lipoprotein particle clearance created_by: midori creation_date: 2010-09-08T11:23:55Z [Term] id: GO:0071831 name: intermediate-density lipoprotein particle clearance namespace: biological_process def: "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] synonym: "IDL clearance" EXACT [GOC:BHF] is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance created_by: midori creation_date: 2010-09-08T11:26:12Z [Term] id: GO:0071832 name: peptide pheromone export involved in regulation of conjugation namespace: biological_process def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] is_a: GO:0000770 ! peptide pheromone export is_a: GO:0046999 ! regulation of conjugation intersection_of: GO:0000770 ! peptide pheromone export intersection_of: regulates GO:0000746 ! conjugation created_by: midori creation_date: 2010-09-09T11:06:46Z [Term] id: GO:0071833 name: peptide pheromone export involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0071832 ! peptide pheromone export involved in regulation of conjugation intersection_of: GO:0000770 ! peptide pheromone export intersection_of: positively_regulates GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2010-09-09T11:09:43Z [Term] id: GO:0071834 name: mating pheromone secretion namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction." [GOC:mah] synonym: "mating-type pheromone secretion" EXACT [GOC:vw] is_a: GO:0030072 ! peptide hormone secretion created_by: midori creation_date: 2010-09-09T11:22:35Z [Term] id: GO:0071835 name: mating pheromone secretion involved in regulation of conjugation namespace: biological_process def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] synonym: "mating-type pheromone secretion involved in conjugation" EXACT [GOC:mah, GOC:vw] is_a: GO:0071834 ! mating pheromone secretion intersection_of: GO:0071834 ! mating pheromone secretion intersection_of: part_of GO:0000746 ! conjugation relationship: part_of GO:0000746 ! conjugation created_by: midori creation_date: 2010-09-09T11:23:19Z [Term] id: GO:0071836 name: nectar secretion namespace: biological_process def: "The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins." [GOC:kad, PMID:19861655] synonym: "nectar production" RELATED [GOC:kad] is_a: GO:0046903 ! secretion created_by: midori creation_date: 2010-09-09T01:06:04Z [Term] id: GO:0071837 name: HMG box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin." [GOC:yaf, InterPro:IPR009071, PMID:18445004] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-09-10T12:05:45Z [Term] id: GO:0071838 name: cell proliferation in bone marrow namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] synonym: "bone marrow cell proliferation" EXACT [GOC:yaf] is_a: GO:0008283 ! cell population proliferation created_by: midori creation_date: 2010-09-10T12:15:41Z [Term] id: GO:0071839 name: apoptotic process in bone marrow cell namespace: biological_process def: "The apoptotic process in cells in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, PMID:17063141] synonym: "apoptosis in bone marrow" NARROW [] synonym: "apoptotic process in bone marrow cell" EXACT [] synonym: "bone marrow cell apoptosis" EXACT [GOC:yaf] synonym: "bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of bone marrow cells" EXACT [GOC:mah] synonym: "programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, bone marrow cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptotic process created_by: midori creation_date: 2010-09-10T12:19:18Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0008150 ! biological_process created_by: midori creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071846 name: actin filament debranching namespace: biological_process def: "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points." [GOC:jh, GOC:mah, PMID:20362448] is_a: GO:0051014 ! actin filament severing created_by: midori creation_date: 2010-09-10T02:15:42Z [Term] id: GO:0071847 name: TNFSF11-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301, PR:000002107] synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF] synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL] synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL] synonym: "TNFSF11-mediated signalling pathway" EXACT [GOC:mah] synonym: "tumor necrosis factor superfamily member 11-mediated signaling pathway" EXACT [Wikipedia:RANKL] is_a: GO:0033209 ! tumor necrosis factor-mediated signaling pathway created_by: midori creation_date: 2010-09-10T02:22:42Z [Term] id: GO:0071848 name: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling namespace: biological_process def: "Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade." [GOC:BHF, PMID:18606301] synonym: "positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling" EXACT [GOC:BHF] synonym: "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling" EXACT [GOC:mah] is_a: GO:0070374 ! positive regulation of ERK1 and ERK2 cascade is_a: GO:0071847 ! TNFSF11-mediated signaling pathway created_by: midori creation_date: 2010-09-10T02:25:31Z [Term] id: GO:0071849 name: G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] is_a: GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2010-09-10T02:46:11Z [Term] id: GO:0071850 name: mitotic cell cycle arrest namespace: biological_process def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah] synonym: "arrest of mitotic cell cycle progression" EXACT [GOC:mah] synonym: "cessation of mitotic cell cycle" EXACT [GOC:mah] synonym: "termination of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0007050 ! cell cycle arrest is_a: GO:0045930 ! negative regulation of mitotic cell cycle created_by: midori creation_date: 2010-09-10T02:56:30Z [Term] id: GO:0071851 name: mitotic G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] synonym: "G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:vw] is_a: GO:0071849 ! G1 cell cycle arrest in response to nitrogen starvation is_a: GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2010-09-10T02:58:09Z [Term] id: GO:0071852 name: fungal-type cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah] synonym: "fungal-type cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071554 ! cell wall organization or biogenesis created_by: midori creation_date: 2010-09-10T03:07:55Z [Term] id: GO:0071853 name: fungal-type cell wall disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a fungal-type cell wall." [GOC:mah] is_a: GO:0031505 ! fungal-type cell wall organization is_a: GO:0044277 ! cell wall disassembly created_by: midori creation_date: 2010-09-10T03:10:47Z [Term] id: GO:0071854 name: cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly namespace: biological_process def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall." [GOC:mah] is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly intersection_of: GO:0016998 ! cell wall macromolecule catabolic process intersection_of: part_of GO:0071853 ! fungal-type cell wall disassembly relationship: part_of GO:0071853 ! fungal-type cell wall disassembly created_by: midori creation_date: 2010-09-10T03:12:08Z [Term] id: GO:0071855 name: neuropeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide receptor." [GOC:kmv, GOC:mah] is_a: GO:0001664 ! G protein-coupled receptor binding created_by: midori creation_date: 2010-09-10T03:21:43Z [Term] id: GO:0071857 name: beta-endorphin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-endorphin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding created_by: midori creation_date: 2010-09-10T03:23:01Z [Term] id: GO:0071858 name: corazonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a corazonin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding created_by: midori creation_date: 2010-09-10T03:23:40Z [Term] id: GO:0071859 name: neuropeptide F receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide F receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding created_by: midori creation_date: 2010-09-10T03:23:56Z [Term] id: GO:0071860 name: proctolin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proctolin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding created_by: midori creation_date: 2010-09-10T03:24:19Z [Term] id: GO:0071861 name: tachykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tachykinin receptor." [GOC:kmv, GOC:mah] is_a: GO:0071855 ! neuropeptide receptor binding created_by: midori creation_date: 2010-09-10T03:24:34Z [Term] id: GO:0071863 name: regulation of cell proliferation in bone marrow namespace: biological_process def: "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] synonym: "regulation of bone marrow cell proliferation" EXACT [GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071838 ! cell proliferation in bone marrow relationship: regulates GO:0071838 ! cell proliferation in bone marrow created_by: midori creation_date: 2010-09-13T02:11:08Z [Term] id: GO:0071864 name: positive regulation of cell proliferation in bone marrow namespace: biological_process def: "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] synonym: "activation of cell proliferation in bone marrow" NARROW [GOC:mah] synonym: "positive regulation of bone marrow cell proliferation" EXACT [GOC:yaf] synonym: "stimulation of cell proliferation in bone marrow" NARROW [GOC:mah] synonym: "up regulation of cell proliferation in bone marrow" EXACT [GOC:mah] synonym: "up-regulation of cell proliferation in bone marrow" EXACT [GOC:mah] synonym: "upregulation of cell proliferation in bone marrow" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0071863 ! regulation of cell proliferation in bone marrow intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071838 ! cell proliferation in bone marrow relationship: positively_regulates GO:0071838 ! cell proliferation in bone marrow created_by: midori creation_date: 2010-09-13T02:12:36Z [Term] id: GO:0071865 name: regulation of apoptotic process in bone marrow cell namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141] synonym: "regulation of apoptosis in bone marrow" NARROW [] synonym: "regulation of apoptotic process in bone marrow" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071839 ! apoptotic process in bone marrow cell relationship: regulates GO:0071839 ! apoptotic process in bone marrow cell created_by: midori creation_date: 2010-09-13T02:16:43Z [Term] id: GO:0071866 name: negative regulation of apoptotic process in bone marrow cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141] synonym: "down regulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "down-regulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "downregulation of apoptosis in bone marrow" EXACT [GOC:mah] synonym: "inhibition of apoptosis in bone marrow" NARROW [GOC:mah] synonym: "negative regulation of apoptosis in bone marrow" NARROW [] synonym: "negative regulation of apoptotic process in bone marrow" EXACT [] synonym: "negative regulation of bone marrow cell apoptosis" EXACT [GOC:mah, GOC:yaf] synonym: "negative regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "negative regulation of killing of bone marrow cells" EXACT [GOC:mah] synonym: "negative regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] synonym: "negative regulation of programmed cell death, bone marrow cells" EXACT [GOC:mah] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071839 ! apoptotic process in bone marrow cell relationship: negatively_regulates GO:0071839 ! apoptotic process in bone marrow cell created_by: midori creation_date: 2010-09-13T02:17:38Z [Term] id: GO:0071867 name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] is_a: GO:0010243 ! response to organonitrogen compound created_by: midori creation_date: 2010-09-13T02:36:37Z [Term] id: GO:0071868 name: cellular response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [CHEBI:35375, GOC:mah] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0071867 ! response to monoamine created_by: midori creation_date: 2010-09-13T02:38:52Z [Term] id: GO:0071869 name: response to catecholamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah] synonym: "response to catecholamine stimulus" EXACT [GOC:dos] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2010-09-13T02:51:13Z [Term] id: GO:0071870 name: cellular response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [CHEBI:33567, GOC:BHF, GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:0071869 ! response to catecholamine is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2010-09-13T02:54:50Z [Term] id: GO:0071871 name: response to epinephrine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to adrenaline stimulus" EXACT [GOC:mah] synonym: "response to epinephrine stimulus" EXACT [GOC:dos] is_a: GO:0071869 ! response to catecholamine created_by: midori creation_date: 2010-09-13T03:27:48Z [Term] id: GO:0071872 name: cellular response to epinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [CHEBI:33568, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to adrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071871 ! response to epinephrine created_by: midori creation_date: 2010-09-13T03:31:40Z [Term] id: GO:0071873 name: response to norepinephrine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] is_a: GO:0071869 ! response to catecholamine created_by: midori creation_date: 2010-09-13T03:31:53Z [Term] id: GO:0071874 name: cellular response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [CHEBI:33569, GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine created_by: midori creation_date: 2010-09-13T03:33:32Z [Term] id: GO:0071875 name: adrenergic receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF] synonym: "adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "adrenoceptor signaling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: midori creation_date: 2010-09-13T03:44:44Z [Term] id: GO:0071876 name: obsolete initiation of adrenergic receptor signal transduction namespace: biological_process def: "OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor." [GOC:BHF, GOC:mah] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "initiation of adrenergic receptor signal transduction" EXACT [] is_obsolete: true consider: GO:0004935 consider: GO:0005179 consider: GO:0071872 consider: GO:0071874 consider: GO:0071875 created_by: midori creation_date: 2010-09-13T04:05:38Z [Term] id: GO:0071877 name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "false" BROAD [] synonym: "regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway relationship: regulates GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:12:10Z [Term] id: GO:0071878 name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "false" BROAD [] synonym: "negative regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway relationship: negatively_regulates GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:15:34Z [Term] id: GO:0071879 name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] synonym: "positive regulation of adrenergic receptor signaling pathway" BROAD [] synonym: "positive regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway relationship: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:15:57Z [Term] id: GO:0071880 name: adenylate cyclase-activating adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "activation of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylate cyclase activating pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylyl cyclase activating pathway" EXACT [GOC:mah] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0071875 ! adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:21:28Z [Term] id: GO:0071881 name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "adrenergic receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:mah] synonym: "adrenergic receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:mah] synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway" RELATED [GOC:mah] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0071875 ! adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:22:53Z [Term] id: GO:0071882 name: phospholipase C-activating adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "activation of phospholipase C activity by adrenergic receptor signaling pathway" RELATED [GOC:bf] synonym: "activation of phospholipase C activity by adrenergic receptor signalling pathway" RELATED [GOC:mah] synonym: "adrenergic receptor, phospholipase C activating pathway" RELATED [GOC:mah] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0071875 ! adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:32:03Z [Term] id: GO:0071883 name: activation of MAPK activity by adrenergic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, followed by the activation of a MAP kinase." [GOC:BHF, GOC:mah] synonym: "activation of MAP kinase activity by adrenergic receptor signaling pathway" EXACT [GOC:mah] synonym: "activation of MAP kinase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] synonym: "activation of MAPK activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0071875 ! adrenergic receptor signaling pathway created_by: midori creation_date: 2010-09-13T04:34:47Z [Term] id: GO:0071885 name: N-terminal protein N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588] synonym: "X-Pro-Lys N-terminal methyltransferase" NARROW [GOC:rn] is_a: GO:0008276 ! protein methyltransferase activity created_by: midori creation_date: 2010-09-13T04:53:57Z [Term] id: GO:0071886 name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding namespace: molecular_function def: "Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug." [CHEBI:100436, GOC:yaf, PMID:19057895] synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436] synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895] synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229] is_a: GO:0008144 ! drug binding is_a: GO:0043176 ! amine binding is_a: GO:0097159 ! organic cyclic compound binding created_by: midori creation_date: 2010-09-14T12:29:36Z [Term] id: GO:0071887 name: leukocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "leukocyte apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process created_by: midori creation_date: 2010-09-14T12:44:09Z [Term] id: GO:0071888 name: macrophage apoptotic process namespace: biological_process def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation-induced cell death" RELATED [GOC:yaf] synonym: "AICD" RELATED [GOC:yaf] synonym: "macrophage apoptosis" NARROW [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process created_by: midori creation_date: 2010-09-14T12:50:40Z [Term] id: GO:0071889 name: 14-3-3 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237] is_a: GO:0005515 ! protein binding created_by: midori creation_date: 2010-09-14T01:21:50Z [Term] id: GO:0071890 name: bicarbonate binding namespace: molecular_function def: "Interacting selectively and non-covalently with bicarbonate (CHO3-) ions." [CHEBI:17544] synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544] is_a: GO:0043168 ! anion binding created_by: midori creation_date: 2010-09-14T01:47:43Z [Term] id: GO:0071891 name: N-terminal peptidyl-proline dimethylation involved in translation namespace: biological_process def: "An N-terminal peptidyl-proline dimethylation process that contributes to translation." [GOC:mah] is_a: GO:0018016 ! N-terminal peptidyl-proline dimethylation intersection_of: GO:0018016 ! N-terminal peptidyl-proline dimethylation intersection_of: part_of GO:0006412 ! translation relationship: part_of GO:0006412 ! translation created_by: midori creation_date: 2010-09-14T02:19:40Z [Term] id: GO:0071892 name: thrombocyte activation namespace: biological_process def: "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals." [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901] synonym: "blood coagulation, thrombocyte activation" EXACT [GOC:mah] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation created_by: midori creation_date: 2010-09-14T03:06:33Z [Term] id: GO:0071893 name: BMP signaling pathway involved in nephric duct formation namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "BMP signalling pathway involved in nephric duct formation" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: part_of GO:0072179 ! nephric duct formation relationship: part_of GO:0072179 ! nephric duct formation created_by: midori creation_date: 2010-09-14T03:14:59Z [Term] id: GO:0071894 name: histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:mah, GOC:vw] synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw] synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw] synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw] is_a: GO:0033523 ! histone H2B ubiquitination created_by: midori creation_date: 2010-09-14T03:43:46Z [Term] id: GO:0071895 name: odontoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin." [GOC:sl, PMID:20425127] is_a: GO:0060563 ! neuroepithelial cell differentiation created_by: midori creation_date: 2010-09-14T04:00:40Z [Term] id: GO:0071896 name: protein localization to adherens junction namespace: biological_process alt_id: GO:1904696 def: "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237] synonym: "protein localisation in adherens junction" EXACT [] synonym: "protein localisation in cell-cell adherens junction" EXACT [] synonym: "protein localisation to adherens junction" EXACT [GOC:mah] synonym: "protein localisation to cell-cell adherens junction" EXACT [] synonym: "protein localization in adherens junction" EXACT [] synonym: "protein localization in cell-cell adherens junction" EXACT [] synonym: "protein localization to cell-cell adherens junction" EXACT [] is_a: GO:0150105 ! protein localization to cell-cell junction created_by: midori creation_date: 2010-09-14T04:03:27Z [Term] id: GO:0071897 name: DNA biosynthetic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah] synonym: "DNA anabolism" EXACT [GOC:mah] synonym: "DNA biosynthesis" EXACT [GOC:mah] synonym: "DNA formation" EXACT [GOC:mah] synonym: "DNA synthesis" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process created_by: midori creation_date: 2010-09-15T02:14:33Z [Term] id: GO:0071898 name: regulation of estrogen receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor." [GOC:BHF, GOC:mah] is_a: GO:0050789 ! regulation of biological process is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0030331 ! estrogen receptor binding relationship: regulates GO:0030331 ! estrogen receptor binding created_by: midori creation_date: 2010-09-15T02:48:49Z [Term] id: GO:0071899 name: negative regulation of estrogen receptor binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor." [GOC:BHF, GOC:mah] is_a: GO:0071898 ! regulation of estrogen receptor binding is_a: GO:1900121 ! negative regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030331 ! estrogen receptor binding relationship: negatively_regulates GO:0030331 ! estrogen receptor binding created_by: midori creation_date: 2010-09-15T02:51:10Z [Term] id: GO:0071900 name: regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004674 ! protein serine/threonine kinase activity relationship: regulates GO:0004674 ! protein serine/threonine kinase activity created_by: midori creation_date: 2010-09-15T03:08:35Z [Term] id: GO:0071901 name: negative regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity created_by: midori creation_date: 2010-09-15T03:09:43Z [Term] id: GO:0071902 name: positive regulation of protein serine/threonine kinase activity namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004674 ! protein serine/threonine kinase activity relationship: positively_regulates GO:0004674 ! protein serine/threonine kinase activity created_by: midori creation_date: 2010-09-15T03:09:57Z [Term] id: GO:0071903 name: protein N-linked N-acetylglucosaminylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0151] synonym: "protein amino acid N-linked N-acetylglucosaminylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0151 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: midori creation_date: 2010-09-15T03:49:16Z [Term] id: GO:0071904 name: protein N-linked N-acetylgalactosaminylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0420] synonym: "protein amino acid N-linked N-acetylgalactosaminylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0420 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: midori creation_date: 2010-09-15T03:52:28Z [Term] id: GO:0071905 name: protein N-linked glucosylation via asparagine namespace: biological_process def: "A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0421] synonym: "protein amino acid N-linked glucosylation via asparagine" EXACT [GOC:bf] xref: RESID:AA0421 is_a: GO:0018279 ! protein N-linked glycosylation via asparagine created_by: midori creation_date: 2010-09-15T03:54:25Z [Term] id: GO:0071906 name: CRD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins." [GOC:yaf, PMID:19460168] synonym: "context dependent regulatory domain binding" EXACT [GOC:mah] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-09-21T04:08:53Z [Term] id: GO:0071907 name: determination of digestive tract left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs] synonym: "determination of gut left/right asymmetry" EXACT [GOC:cvs] synonym: "determination of left/right asymmetry of the digestive tract" EXACT [GOC:cvs] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048565 ! digestive tract development created_by: midori creation_date: 2010-09-22T10:14:29Z [Term] id: GO:0071908 name: determination of intestine left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0071907 ! determination of digestive tract left/right asymmetry created_by: midori creation_date: 2010-09-22T10:24:33Z [Term] id: GO:0071909 name: determination of stomach left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0071907 ! determination of digestive tract left/right asymmetry relationship: part_of GO:0062094 ! stomach development created_by: midori creation_date: 2010-09-22T10:25:30Z [Term] id: GO:0071910 name: determination of liver left/right asymmetry namespace: biological_process def: "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism." [GOC:cvs] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0001889 ! liver development created_by: midori creation_date: 2010-09-22T10:26:47Z [Term] id: GO:0071911 name: synchronous neurotransmitter secretion namespace: biological_process def: "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] is_a: GO:0007269 ! neurotransmitter secretion created_by: midori creation_date: 2010-09-22T01:38:36Z [Term] id: GO:0071912 name: asynchronous neurotransmitter secretion namespace: biological_process def: "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] is_a: GO:0007269 ! neurotransmitter secretion created_by: midori creation_date: 2010-09-22T01:45:35Z [Term] id: GO:0071913 name: citrate secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mah, GOC:mtg_transport, GOC:vw] synonym: "citrate carrier activity" EXACT [GOC:mah] is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity is_a: GO:0015137 ! citrate transmembrane transporter activity created_by: midori creation_date: 2010-09-22T02:18:54Z [Term] id: GO:0071914 name: prominosome namespace: cellular_component def: "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known." [GOC:vesicles, PMID:15976444, PMID:17109118, PMID:17283184] synonym: "prominin-containing extracellular membrane vesicle" EXACT [] is_a: GO:1903561 ! extracellular vesicle created_by: midori creation_date: 2010-09-24T09:24:36Z [Term] id: GO:0071915 name: protein-lysine lysylation namespace: biological_process def: "The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:imk, GOC:jsg, PMID:20729861] synonym: "protein amino acid lysylation" EXACT [GOC:imk] is_a: GO:0018205 ! peptidyl-lysine modification relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification created_by: midori creation_date: 2010-09-24T10:01:57Z [Term] id: GO:0071916 name: dipeptide transmembrane transporter activity namespace: molecular_function alt_id: GO:0042936 def: "Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:mah] synonym: "dipeptide transporter activity" RELATED [] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity relationship: part_of GO:0035442 ! dipeptide transmembrane transport created_by: midori creation_date: 2010-09-24T10:32:36Z [Term] id: GO:0071917 name: triose-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a triose phosphate from one side of a membrane to the other." [GOC:mah, GOC:vw] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0035436 ! triose phosphate transmembrane transport created_by: midori creation_date: 2010-09-24T10:35:26Z [Term] id: GO:0071918 name: urea transmembrane transport namespace: biological_process def: "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "urea membrane transport" EXACT [] is_a: GO:0015840 ! urea transport is_a: GO:0055085 ! transmembrane transport created_by: midori creation_date: 2010-09-24T10:41:36Z [Term] id: GO:0071919 name: G-quadruplex DNA formation namespace: biological_process def: "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422] synonym: "G quadruplex DNA formation" EXACT [GOC:mah] synonym: "G quartet DNA formation" EXACT [GOC:mah] synonym: "G-quartet DNA formation" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process created_by: midori creation_date: 2010-09-24T10:57:43Z [Term] id: GO:0071920 name: cleavage body namespace: cellular_component def: "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386] is_a: GO:0016604 ! nuclear body created_by: midori creation_date: 2010-09-28T10:35:05Z [Term] id: GO:0071921 name: cohesin loading namespace: biological_process def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA." [GOC:dph, GOC:mah, GOC:vw, PMID:10882066, PMID:17113138, PMID:26687354] synonym: "cohesin association with chromatin" EXACT [GOC:lb] synonym: "cohesin localisation to chromatin" EXACT [GOC:mah] synonym: "cohesin localization to chromatin" EXACT [GOC:vw] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:0071168 ! protein localization to chromatin relationship: part_of GO:0034085 ! establishment of sister chromatid cohesion created_by: midori creation_date: 2010-09-28T11:07:26Z [Term] id: GO:0071922 name: regulation of cohesin loading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] synonym: "regulation of cohesin association with chromatin" EXACT [GOC:lb] synonym: "regulation of cohesin localisation to chromatin" EXACT [GOC:mah] synonym: "regulation of cohesin localization to chromatin" EXACT [GOC:vw] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0051101 ! regulation of DNA binding is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071921 ! cohesin loading relationship: regulates GO:0071921 ! cohesin loading created_by: midori creation_date: 2010-09-28T11:13:35Z [Term] id: GO:0071923 name: negative regulation of cohesin loading namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] synonym: "negative regulation of cohesin association with chromatin" EXACT [GOC:lb] synonym: "negative regulation of cohesin localisation to chromatin" EXACT [GOC:mah] synonym: "negative regulation of cohesin localization to chromatin" RELATED [GOC:vw] is_a: GO:0045875 ! negative regulation of sister chromatid cohesion is_a: GO:0071922 ! regulation of cohesin loading is_a: GO:0120186 ! negative regulation of protein localization to chromatin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071921 ! cohesin loading relationship: negatively_regulates GO:0071921 ! cohesin loading created_by: midori creation_date: 2010-09-28T11:17:50Z [Term] id: GO:0071924 name: chemokine (C-C motif) ligand 22 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724] synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah] synonym: "CCL-22 production" EXACT [GOC:mah] synonym: "CCL22 production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-09-28T11:33:13Z [Term] id: GO:0071925 name: thymic stromal lymphopoietin production namespace: biological_process def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180] synonym: "TSLP production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-09-28T11:38:55Z [Term] id: GO:0071926 name: endocannabinoid signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol." [GOC:bf, GOC:mah, PMID:15550444] synonym: "endocannabinoid signalling pathway" EXACT [GOC:mah] is_a: GO:0038171 ! cannabinoid signaling pathway created_by: midori creation_date: 2010-09-28T11:52:03Z [Term] id: GO:0071927 name: octopamine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245] synonym: "octopamine signalling pathway" EXACT [GOC:mah] is_a: GO:0007211 ! octopamine or tyramine signaling pathway created_by: midori creation_date: 2010-09-28T01:18:57Z [Term] id: GO:0071928 name: tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245] synonym: "tyramine signalling pathway" EXACT [GOC:mah] is_a: GO:0007211 ! octopamine or tyramine signaling pathway created_by: midori creation_date: 2010-09-28T01:20:10Z [Term] id: GO:0071929 name: alpha-tubulin acetylation namespace: biological_process def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050] is_a: GO:0018393 ! internal peptidyl-lysine acetylation created_by: midori creation_date: 2010-09-28T01:46:38Z [Term] id: GO:0071930 name: negative regulation of transcription involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] synonym: "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2010-09-29T11:12:11Z [Term] id: GO:0071931 name: positive regulation of transcription involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] synonym: "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2010-09-29T11:15:34Z [Term] id: GO:0071932 name: replication fork reversal namespace: biological_process def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929] is_a: GO:0031297 ! replication fork processing created_by: midori creation_date: 2010-09-29T02:34:22Z [Term] id: GO:0071933 name: Arp2/3 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah] is_a: GO:0044877 ! protein-containing complex binding created_by: midori creation_date: 2010-09-29T02:48:41Z [Term] id: GO:0071934 name: thiamine transmembrane transport namespace: biological_process def: "The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "thiamin transmembrane transport" EXACT [GOC:mah] synonym: "thiamine membrane transport" EXACT [] synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015888 ! thiamine transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport created_by: midori creation_date: 2010-09-29T02:59:39Z [Term] id: GO:0071935 name: octopamine signaling pathway involved in response to food namespace: biological_process def: "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus." [GOC:mah, PMID:19609300] synonym: "octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0071927 ! octopamine signaling pathway intersection_of: GO:0071927 ! octopamine signaling pathway intersection_of: part_of GO:0032094 ! response to food relationship: part_of GO:0032094 ! response to food created_by: midori creation_date: 2010-09-30T11:55:59Z [Term] id: GO:0071936 name: coreceptor activity involved in Wnt signaling pathway namespace: molecular_function def: "In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway." [GOC:BHF, GOC:mah] synonym: "coreceptor activity involved in Wnt receptor signaling pathway" EXACT [] synonym: "coreceptor activity involved in Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "coreceptor activity involved in Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "Wnt co-receptor activity" EXACT [GOC:bf] is_a: GO:0015026 ! coreceptor activity intersection_of: GO:0015026 ! coreceptor activity intersection_of: part_of GO:0016055 ! Wnt signaling pathway relationship: part_of GO:0016055 ! Wnt signaling pathway created_by: midori creation_date: 2010-09-30T03:54:34Z [Term] id: GO:0071938 name: vitamin A transport namespace: biological_process def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake and transport" RELATED [GOC:rs] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0034633 ! retinol transport is_a: GO:0051180 ! vitamin transport created_by: midori creation_date: 2010-09-30T04:15:10Z [Term] id: GO:0071939 name: vitamin A import namespace: biological_process def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0071938 ! vitamin A transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: midori creation_date: 2010-09-30T04:36:22Z [Term] id: GO:0071940 name: fungal-type cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah, GOC:vw, PMID:19646873] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] is_a: GO:0031505 ! fungal-type cell wall organization is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis created_by: midori creation_date: 2010-09-30T04:59:36Z [Term] id: GO:0071941 name: nitrogen cycle metabolic process namespace: biological_process def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe xref: Wikipedia:Nitrogen_cycle is_a: GO:0006807 ! nitrogen compound metabolic process created_by: midori creation_date: 2010-09-30T05:21:03Z [Term] id: GO:0071942 name: XPC complex namespace: cellular_component def: "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824] is_a: GO:0000109 ! nucleotide-excision repair complex created_by: midori creation_date: 2010-10-01T11:09:36Z [Term] id: GO:0071943 name: Myc-Max complex namespace: cellular_component def: "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max." [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: midori creation_date: 2010-10-01T11:56:17Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical entity created_by: midori creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071945 name: regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed namespace: biological_process def: "A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein." [GOC:cilia, GOC:jl, PMID:20371342] synonym: "regulation of bacterial-type flagellar cell motility by regulation of motor speed" RELATED [] synonym: "regulation of bacterial-type flagellum cell motility by regulation of motor speed" EXACT [] synonym: "regulation of flagellar cell motility by regulation of motor speed" BROAD [] is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility created_by: midori creation_date: 2010-10-05T04:10:27Z [Term] id: GO:0071946 name: cis-acting DNA replication termination namespace: biological_process def: "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing." [GOC:vw, PMID:20850009] synonym: "cis acting DNA replication termination" EXACT [GOC:vw] is_a: GO:0071170 ! site-specific DNA replication termination created_by: midori creation_date: 2010-10-06T01:08:48Z [Term] id: GO:0071947 name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process namespace: biological_process def: "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah] is_a: GO:0016579 ! protein deubiquitination is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process intersection_of: GO:0016579 ! protein deubiquitination intersection_of: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2010-10-06T02:06:10Z [Term] id: GO:0071948 name: activation-induced B cell apoptotic process namespace: biological_process def: "B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death." [GOC:mtg_apoptosis, GOC:tfm, PMID:11032170, PMID:19300454] synonym: "activated B cell apoptosis" BROAD [GOC:tfm] synonym: "activation-induced B cell apoptosis" NARROW [] synonym: "activation-induced B-cell apoptosis" EXACT [GOC:tfm] synonym: "activation-induced cell death of B cells" EXACT [GOC:tfm] synonym: "activation-induced cell death of B lymphocytes" EXACT [GOC:tfm] synonym: "activation-induced cell death of B-cells" EXACT [GOC:tfm] synonym: "activation-induced cell death of B-lymphocytes" EXACT [GOC:tfm] synonym: "AICD" BROAD [GOC:tfm] synonym: "antigen-driven apoptosis" BROAD [GOC:tfm] is_a: GO:0001783 ! B cell apoptotic process created_by: midori creation_date: 2010-10-06T02:47:46Z [Term] id: GO:0071949 name: FAD binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] synonym: "oxidized flavin adenine dinucleotide binding" EXACT [GOC:mah] synonym: "oxidized flavine-adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0050660 ! flavin adenine dinucleotide binding created_by: midori creation_date: 2010-10-07T12:30:28Z [Term] id: GO:0071950 name: FADH2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] synonym: "reduced flavin adenine dinucleotide binding" EXACT [GOC:mah] synonym: "reduced flavine-adenine dinucleotide binding" EXACT [GOC:mah] is_a: GO:0050660 ! flavin adenine dinucleotide binding created_by: midori creation_date: 2010-10-07T12:31:34Z [Term] id: GO:0071951 name: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045] is_a: GO:0019988 ! charged-tRNA amino acid modification created_by: midori creation_date: 2010-10-08T11:54:38Z [Term] id: GO:0071952 name: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA." [GOC:jsg, PMID:17351629, PMID:18559341] comment: Note that this process has been observed in some archaeal and bacterial species. is_a: GO:0019988 ! charged-tRNA amino acid modification created_by: midori creation_date: 2010-10-08T12:02:00Z [Term] id: GO:0071953 name: elastic fiber namespace: cellular_component def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] synonym: "elastic fibre" EXACT [GOC:mah] synonym: "elastin fiber" EXACT [GOC:BHF] is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0031012 ! extracellular matrix created_by: midori creation_date: 2010-10-11T11:44:57Z [Term] id: GO:0071954 name: chemokine (C-C motif) ligand 11 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9600955] synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah] synonym: "CCL-11 production" EXACT [GOC:mah] synonym: "CCL11 production" EXACT [GOC:mah] synonym: "eotaxin production" BROAD [GOC:mah] synonym: "eotaxin-1 production" EXACT [GOC:mah] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2010-10-08T12:10:34Z [Term] id: GO:0071955 name: recycling endosome to Golgi transport namespace: biological_process def: "The directed movement of substances from recycling endosomes to the Golgi." [GOC:lb] is_a: GO:0042147 ! retrograde transport, endosome to Golgi is_a: GO:0048193 ! Golgi vesicle transport created_by: midori creation_date: 2010-10-08T01:19:00Z [Term] id: GO:0071957 name: old mitotic spindle pole body namespace: cellular_component def: "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis." [GOC:mah, GOC:vw, PMID:15132994] synonym: "old SPB" EXACT [GOC:mah] is_a: GO:0044732 ! mitotic spindle pole body created_by: midori creation_date: 2011-06-01T02:32:10Z [Term] id: GO:0071958 name: new mitotic spindle pole body namespace: cellular_component def: "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize." [GOC:mah, GOC:vw, PMID:15132994] synonym: "new SPB" EXACT [GOC:mah] is_a: GO:0044732 ! mitotic spindle pole body created_by: midori creation_date: 2011-06-01T02:34:34Z [Term] id: GO:0071959 name: maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] synonym: "maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:mah] synonym: "maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:mah] is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: part_of GO:0071961 ! mitotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-01T04:08:43Z [Term] id: GO:0071960 name: maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] synonym: "maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] synonym: "maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:mah] synonym: "maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:mah] is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-01T04:10:59Z [Term] id: GO:0071961 name: mitotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis." [GOC:mah] synonym: "mitotic sister chromatid cohesion along arms" EXACT [GOC:mah] synonym: "sister chromatid cohesion along arms at mitosis" EXACT [GOC:mah] is_a: GO:0007064 ! mitotic sister chromatid cohesion created_by: midori creation_date: 2011-06-02T11:21:13Z [Term] id: GO:0071962 name: mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah] synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah] synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah] is_a: GO:0007064 ! mitotic sister chromatid cohesion is_a: GO:0070601 ! centromeric sister chromatid cohesion created_by: midori creation_date: 2011-06-02T11:24:17Z [Term] id: GO:0071963 name: establishment or maintenance of cell polarity regulating cell shape namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity is_a: GO:0008360 ! regulation of cell shape created_by: midori creation_date: 2011-06-21T03:47:21Z [Term] id: GO:0071964 name: establishment of cell polarity regulating cell shape namespace: biological_process def: "Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell." [GOC:mah] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-22T03:10:08Z [Term] id: GO:0071965 name: multicellular organismal locomotion namespace: biological_process def: "Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another." [GOC:mah] is_a: GO:0040011 ! locomotion is_a: GO:0050879 ! multicellular organismal movement created_by: midori creation_date: 2010-10-14T10:34:35Z [Term] id: GO:0071966 name: fungal-type cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall." [GOC:mah] is_a: GO:0010383 ! cell wall polysaccharide metabolic process relationship: part_of GO:0071852 ! fungal-type cell wall organization or biogenesis created_by: midori creation_date: 2010-10-14T11:56:47Z [Term] id: GO:0071967 name: lipopolysaccharide core heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122] synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5122 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity created_by: midori creation_date: 2010-10-14T05:13:31Z [Term] id: GO:0071968 name: lipid A-core heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127] xref: MetaCyc:RXN0-5127 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity created_by: midori creation_date: 2010-10-14T05:15:22Z [Term] id: GO:0071969 name: fungal-type cell wall (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi." [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-D-glucan metabolic process" EXACT [] synonym: "fungal-type cell wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3 glucan metabolism" EXACT [GOC:mah] is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process created_by: midori creation_date: 2010-10-18T03:25:38Z [Term] id: GO:0071970 name: fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls." [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-D-glucan biosynthetic process" EXACT [] synonym: "fungal-type cell wall 1,3-beta-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall 1,3-beta-glucan synthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan anabolism" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan biosynthesis" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan biosynthetic process" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan formation" EXACT [GOC:mah] synonym: "fungal-type cell wall beta-1,3-glucan synthesis" EXACT [GOC:mah] is_a: GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process created_by: midori creation_date: 2010-10-18T03:25:56Z [Term] id: GO:0071971 name: extracellular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0097734 ! extracellular exosome biogenesis created_by: midori creation_date: 2010-10-18T03:44:18Z [Term] id: GO:0071972 name: peptidoglycan L,D-transpeptidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine." [MetaCyc:RXN-11349] xref: MetaCyc:RXN-11349 is_a: GO:0004185 ! serine-type carboxypeptidase activity created_by: midori creation_date: 2010-10-18T04:36:19Z [Term] id: GO:0071973 name: bacterial-type flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:krc, GOC:mah] subset: goslim_metagenomics synonym: "bacterial-type flagellar cell motility" RELATED [] synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah] is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility created_by: midori creation_date: 2010-10-21T12:00:53Z [Term] id: GO:0071975 name: cell swimming namespace: biological_process def: "Cell motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074] synonym: "cell swimming motility" EXACT [GOC:mah] is_a: GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-21T02:31:34Z [Term] id: GO:0071976 name: cell gliding namespace: biological_process def: "Cell motility that results in the smooth movement of a cell along a solid surface." [PMID:18461074] synonym: "cell gliding motility" EXACT [GOC:mah] is_a: GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-21T02:33:24Z [Term] id: GO:0071977 name: bacterial-type flagellum-dependent swimming motility namespace: biological_process def: "Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium." [GOC:cilia, PMID:18461074] synonym: "bacterial-type flagellar swimming motility" RELATED [] synonym: "bacterial-type flagellum-mediated cell swimming" EXACT [GOC:mah] is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility is_a: GO:0071975 ! cell swimming created_by: midori creation_date: 2010-10-21T02:58:51Z [Term] id: GO:0071978 name: bacterial-type flagellum-dependent swarming motility namespace: biological_process def: "Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria." [GOC:cilia, PMID:14527279, PMID:18461074] synonym: "bacterial-type flagellar swarming motility" RELATED [] synonym: "bacterial-type flagellum-mediated cell swarming" EXACT [GOC:mah] is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility created_by: midori creation_date: 2010-10-21T03:00:14Z [Term] id: GO:0071979 name: cytoskeleton-mediated cell swimming namespace: biological_process def: "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium." [PMID:18461074] synonym: "cytoskeleton-mediated swimming motility" EXACT [GOC:mah] is_a: GO:0071975 ! cell swimming created_by: midori creation_date: 2010-10-21T03:02:36Z [Term] id: GO:0071980 name: cell surface adhesin-mediated gliding motility namespace: biological_process def: "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." [PMID:18461074] is_a: GO:0071976 ! cell gliding created_by: midori creation_date: 2010-10-21T03:03:44Z [Term] id: GO:0071981 name: exit from diapause namespace: biological_process def: "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] is_a: GO:0022611 ! dormancy process created_by: midori creation_date: 2010-10-21T04:45:40Z [Term] id: GO:0071982 name: maintenance of diapause namespace: biological_process def: "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] is_a: GO:0022611 ! dormancy process created_by: midori creation_date: 2010-10-21T04:46:32Z [Term] id: GO:0071983 name: exit from reproductive diapause namespace: biological_process def: "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] is_a: GO:0071981 ! exit from diapause created_by: midori creation_date: 2010-10-21T04:48:12Z [Term] id: GO:0071984 name: maintenance of reproductive diapause namespace: biological_process def: "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] is_a: GO:0071982 ! maintenance of diapause created_by: midori creation_date: 2010-10-21T04:49:28Z [Term] id: GO:0071985 name: multivesicular body sorting pathway namespace: biological_process def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537] is_a: GO:0016192 ! vesicle-mediated transport created_by: midori creation_date: 2010-10-22T12:04:16Z [Term] id: GO:0071986 name: Ragulator complex namespace: cellular_component def: "A eukaryotically conserved protein complex; in humans, it is comprised of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via LAMTOR1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases." [GOC:krc, GOC:lb, GOC:vw, PMID:19177150, PMID:20381137, PMID:22980980, PMID:29199950] synonym: "MAPKSP1/ROBLD3/C11orf59 complex" EXACT [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031902 ! late endosome membrane relationship: part_of GO:0045121 ! membrane raft created_by: midori creation_date: 2010-10-22T02:42:13Z [Term] id: GO:0071987 name: WD40-repeat domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain." [GOC:yaf, InterPro:IPR017986] synonym: "beta-transducin repeat domain binding" EXACT [GOC:yaf] synonym: "WD domain binding" EXACT [GOC:yaf] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2010-10-22T02:53:29Z [Term] id: GO:0071988 name: protein localization to spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah] synonym: "protein localisation to spindle pole body" EXACT [GOC:mah] is_a: GO:1905508 ! protein localization to microtubule organizing center created_by: midori creation_date: 2010-10-25T10:56:33Z [Term] id: GO:0071989 name: establishment of protein localization to spindle pole body namespace: biological_process def: "The directed movement of a protein to a specific location at the spindle pole body." [GOC:mah] synonym: "establishment of protein localisation to spindle pole body" EXACT [GOC:mah] is_a: GO:0071988 ! protein localization to spindle pole body is_a: GO:0072594 ! establishment of protein localization to organelle created_by: midori creation_date: 2010-10-25T11:01:17Z [Term] id: GO:0071990 name: maintenance of protein location to spindle pole body namespace: biological_process def: "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere." [GOC:mah, GOC:vw] synonym: "maintenance of protein location at spindle pole body" EXACT [] synonym: "maintenance of protein location in spindle pole body" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005816 ! spindle pole body relationship: occurs_in GO:0005816 ! spindle pole body relationship: part_of GO:0051300 ! spindle pole body organization relationship: part_of GO:0071988 ! protein localization to spindle pole body created_by: midori creation_date: 2010-10-25T11:02:31Z [Term] id: GO:0071993 name: phytochelatin transport namespace: biological_process def: "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] synonym: "cadystin transport" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] is_a: GO:0015833 ! peptide transport created_by: midori creation_date: 2010-10-25T01:57:55Z [Term] id: GO:0071994 name: phytochelatin transmembrane transport namespace: biological_process def: "The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "cadystin transmembrane transport" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "phytochelatin membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071993 ! phytochelatin transport created_by: midori creation_date: 2010-10-25T01:58:50Z [Term] id: GO:0071995 name: phytochelatin import into vacuole namespace: biological_process def: "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] synonym: "cadystin import into vacuole" RELATED [GOC:vw, http://en.wikipedia.org/wiki/Phytochelatin#History] synonym: "phytochelatin transport into vacuole" EXACT [GOC:vw] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0071994 ! phytochelatin transmembrane transport created_by: midori creation_date: 2010-10-25T02:01:59Z [Term] id: GO:0071996 name: glutathione transmembrane import into vacuole namespace: biological_process def: "The directed movement of glutathione into the vacuole across the vacuolar membrane." [GOC:mah] synonym: "glutathione transport into vacuole" EXACT [GOC:vw] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0034775 ! glutathione transmembrane transport created_by: midori creation_date: 2010-10-25T02:12:01Z [Term] id: GO:0071998 name: ascospore release from ascus namespace: biological_process def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah] synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048869 ! cellular developmental process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore created_by: midori creation_date: 2010-10-25T03:41:44Z [Term] id: GO:0071999 name: extracellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw] synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah] synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah] synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah] is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0046379 ! extracellular polysaccharide metabolic process created_by: midori creation_date: 2010-10-25T05:11:25Z [Term] id: GO:0072000 name: extracellular polysaccharide catabolic process involved in ascospore release from ascus namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah, GOC:vw] synonym: "ascus catabolic process" RELATED [GOC:vw] synonym: "ascus endolysis" RELATED [GOC:vw] synonym: "extracellular polysaccharide breakdown involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "extracellular polysaccharide catabolism involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "extracellular polysaccharide degradation involved in ascospore release from ascus" EXACT [GOC:mah] is_a: GO:0071999 ! extracellular polysaccharide catabolic process is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0071999 ! extracellular polysaccharide catabolic process intersection_of: part_of GO:0071998 ! ascospore release from ascus relationship: part_of GO:0071998 ! ascospore release from ascus created_by: midori creation_date: 2010-10-25T05:30:41Z [Term] id: GO:0072001 name: renal system development namespace: biological_process def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System] subset: gocheck_do_not_annotate synonym: "urinary system development" BROAD [GOC:yaf] synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] is_a: GO:0048731 ! system development relationship: part_of GO:0001655 ! urogenital system development created_by: midori creation_date: 2010-01-25T10:31:00Z [Term] id: GO:0072002 name: Malpighian tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135] is_a: GO:0048513 ! animal organ development is_a: GO:0061326 ! renal tubule development created_by: midori creation_date: 2010-01-25T10:54:30Z [Term] id: GO:0072003 name: kidney rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060993 ! kidney morphogenesis created_by: midori creation_date: 2010-01-25T11:18:58Z [Term] id: GO:0072004 name: kidney field specification namespace: biological_process def: "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10] synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010092 ! specification of animal organ identity is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0072003 ! kidney rudiment formation created_by: midori creation_date: 2010-01-25T11:24:33Z [Term] id: GO:0072005 name: maintenance of kidney identity namespace: biological_process def: "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048496 ! maintenance of animal organ identity relationship: part_of GO:0072003 ! kidney rudiment formation created_by: midori creation_date: 2010-01-25T11:57:41Z [Term] id: GO:0072006 name: nephron development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] synonym: "nephrogenesis" RELATED [GOC:rph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T01:37:16Z [Term] id: GO:0072007 name: mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:1904238 ! pericyte cell differentiation created_by: midori creation_date: 2010-01-25T01:59:09Z [Term] id: GO:0072008 name: glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0072007 ! mesangial cell differentiation relationship: part_of GO:0072109 ! glomerular mesangium development created_by: midori creation_date: 2010-01-25T01:59:33Z [Term] id: GO:0072009 name: nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T02:01:39Z [Term] id: GO:0072010 name: glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development relationship: part_of GO:0032835 ! glomerulus development created_by: midori creation_date: 2010-01-25T02:02:14Z [Term] id: GO:0072011 name: glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0003158 ! endothelium development is_a: GO:0072010 ! glomerular epithelium development relationship: part_of GO:0072012 ! glomerulus vasculature development created_by: midori creation_date: 2010-01-25T02:02:57Z [Term] id: GO:0072012 name: glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0001568 ! blood vessel development is_a: GO:0061440 ! kidney vasculature development relationship: part_of GO:0032835 ! glomerulus development created_by: midori creation_date: 2010-01-25T02:05:04Z [Term] id: GO:0072013 name: glomus development namespace: biological_process def: "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318] synonym: "pronephric glomus development" EXACT [GOC:mtg_kidney_jan10, PMID:15895368] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048793 ! pronephros development created_by: midori creation_date: 2010-01-25T02:23:19Z [Term] id: GO:0072014 name: proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-01-25T02:33:46Z [Term] id: GO:0072015 name: glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation created_by: midori creation_date: 2010-01-25T02:12:45Z [Term] id: GO:0072016 name: glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation created_by: midori creation_date: 2010-01-25T02:13:16Z [Term] id: GO:0072017 name: distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-01-25T02:34:19Z [Term] id: GO:0072019 name: proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0072014 ! proximal tubule development created_by: midori creation_date: 2010-01-25T02:35:35Z [Term] id: GO:0072020 name: proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0072014 ! proximal tubule development created_by: midori creation_date: 2010-01-25T02:36:14Z [Term] id: GO:0072021 name: ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0072070 ! loop of Henle development created_by: midori creation_date: 2010-01-25T02:37:13Z [Term] id: GO:0072022 name: descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072070 ! loop of Henle development created_by: midori creation_date: 2010-01-25T02:37:47Z [Term] id: GO:0072023 name: thick ascending limb development namespace: biological_process alt_id: GO:0072026 def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0072017 ! distal tubule development created_by: midori creation_date: 2010-01-25T02:39:51Z [Term] id: GO:0072024 name: macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development relationship: part_of GO:0072051 ! juxtaglomerular apparatus development created_by: midori creation_date: 2010-01-25T02:40:15Z [Term] id: GO:0072025 name: distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development relationship: part_of GO:0072017 ! distal tubule development created_by: midori creation_date: 2010-01-25T02:40:45Z [Term] id: GO:0072027 name: connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10] synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-01-25T02:42:05Z [Term] id: GO:0072028 name: nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060993 ! kidney morphogenesis relationship: part_of GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T02:45:52Z [Term] id: GO:0072029 name: long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10] synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T02:49:08Z [Term] id: GO:0072030 name: short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T02:49:32Z [Term] id: GO:0072031 name: proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612] synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0072019 ! proximal convoluted tubule development created_by: midori creation_date: 2010-01-25T02:55:57Z [Term] id: GO:0072032 name: proximal convoluted tubule segment 2 development namespace: biological_process def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613] synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0072019 ! proximal convoluted tubule development created_by: midori creation_date: 2010-01-25T02:56:36Z [Term] id: GO:0072033 name: renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072077 ! renal vesicle morphogenesis created_by: midori creation_date: 2010-01-25T02:57:03Z [Term] id: GO:0072034 name: renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10] synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10] synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0031128 ! developmental induction is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium relationship: positively_regulates GO:0072033 ! renal vesicle formation created_by: midori creation_date: 2010-01-25T02:58:18Z [Term] id: GO:0072035 name: pre-tubular aggregate formation namespace: biological_process def: "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10] synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0072033 ! renal vesicle formation created_by: midori creation_date: 2010-01-25T03:03:10Z [Term] id: GO:0072036 name: mesenchymal to epithelial transition involved in renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: part_of GO:0072033 ! renal vesicle formation relationship: part_of GO:0072033 ! renal vesicle formation created_by: midori creation_date: 2010-01-25T03:04:24Z [Term] id: GO:0072037 name: mesenchymal stem cell differentiation involved in nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:07:39Z [Term] id: GO:0072038 name: mesenchymal stem cell maintenance involved in nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0035019 ! somatic stem cell population maintenance relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:08:05Z [Term] id: GO:0072039 name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:0090183 ! regulation of kidney development is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904672 ! regulation of somatic stem cell population maintenance is_a: GO:2000027 ! regulation of animal organ morphogenesis is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:08:34Z [Term] id: GO:0072040 name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:09:30Z [Term] id: GO:0072041 name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:10:32Z [Term] id: GO:0072042 name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:11:26Z [Term] id: GO:0072043 name: regulation of pre-tubular aggregate formation by cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] synonym: "regulation of pre-tubular aggregate formation by cell-cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0090183 ! regulation of kidney development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072035 ! pre-tubular aggregate formation relationship: regulates GO:0072035 ! pre-tubular aggregate formation created_by: midori creation_date: 2010-01-25T03:12:03Z [Term] id: GO:0072044 name: collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T03:18:06Z [Term] id: GO:0072045 name: convergent extension involved in nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:22:47Z [Term] id: GO:0072046 name: establishment of planar polarity involved in nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0001736 ! establishment of planar polarity intersection_of: GO:0001736 ! establishment of planar polarity intersection_of: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:24:04Z [Term] id: GO:0072047 name: proximal/distal pattern formation involved in nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10] synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0009954 ! proximal/distal pattern formation is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0009954 ! proximal/distal pattern formation intersection_of: part_of GO:0072006 ! nephron development relationship: part_of GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T03:30:48Z [Term] id: GO:0072048 name: renal system pattern specification namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10] synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0072001 ! renal system development created_by: midori creation_date: 2010-01-25T03:31:51Z [Term] id: GO:0072049 name: comma-shaped body morphogenesis namespace: biological_process def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:44:48Z [Term] id: GO:0072050 name: S-shaped body morphogenesis namespace: biological_process def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-01-25T03:45:19Z [Term] id: GO:0072051 name: juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T03:52:23Z [Term] id: GO:0072052 name: juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072051 ! juxtaglomerular apparatus development created_by: midori creation_date: 2010-01-25T03:58:01Z [Term] id: GO:0072053 name: renal inner medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10] synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T03:59:37Z [Term] id: GO:0072054 name: renal outer medulla development namespace: biological_process def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10] synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T04:00:42Z [Term] id: GO:0072055 name: renal cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T04:01:12Z [Term] id: GO:0072056 name: pyramid development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "kidney pyramid development" EXACT [GOC:mah] synonym: "pyramids development" EXACT [GOC:mah] synonym: "renal medulla development" EXACT [GOC:mah] synonym: "renal pyramid development" EXACT [GOC:mah] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T04:01:36Z [Term] id: GO:0072057 name: inner stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072054 ! renal outer medulla development created_by: midori creation_date: 2010-01-25T04:01:58Z [Term] id: GO:0072058 name: outer stripe development namespace: biological_process def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072054 ! renal outer medulla development created_by: midori creation_date: 2010-01-25T04:02:56Z [Term] id: GO:0072059 name: cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0048856 ! anatomical structure development created_by: midori creation_date: 2010-01-25T04:07:07Z [Term] id: GO:0072060 name: outer medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development created_by: midori creation_date: 2010-01-25T04:08:18Z [Term] id: GO:0072061 name: inner medullary collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development created_by: midori creation_date: 2010-01-25T04:08:45Z [Term] id: GO:0072062 name: proximal convoluted tubule segment 1 cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072031 ! proximal convoluted tubule segment 1 development created_by: midori creation_date: 2010-01-25T04:11:17Z [Term] id: GO:0072063 name: short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072030 ! short nephron development created_by: midori creation_date: 2010-01-25T04:12:39Z [Term] id: GO:0072064 name: long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072029 ! long nephron development created_by: midori creation_date: 2010-01-25T04:13:17Z [Term] id: GO:0072065 name: long descending thin limb bend development namespace: biological_process def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0072064 ! long descending thin limb development created_by: midori creation_date: 2010-01-25T04:13:38Z [Term] id: GO:0072066 name: prebend segment development namespace: biological_process def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development relationship: part_of GO:0072022 ! descending thin limb development created_by: midori creation_date: 2010-01-25T04:14:02Z [Term] id: GO:0072067 name: early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development relationship: part_of GO:0072025 ! distal convoluted tubule development created_by: midori creation_date: 2010-01-25T04:15:17Z [Term] id: GO:0072068 name: late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development relationship: part_of GO:0072025 ! distal convoluted tubule development created_by: midori creation_date: 2010-01-25T04:15:50Z [Term] id: GO:0072069 name: DCT cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072025 ! distal convoluted tubule development created_by: midori creation_date: 2010-01-25T04:17:22Z [Term] id: GO:0072070 name: loop of Henle development namespace: biological_process alt_id: GO:0072018 def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "intermediate tubule development" EXACT [] is_a: GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-01-25T04:20:27Z [Term] id: GO:0072071 name: kidney interstitial fibroblast differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development created_by: midori creation_date: 2010-01-25T04:34:31Z [Term] id: GO:0072072 name: kidney stroma development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061448 ! connective tissue development is_a: GO:0072074 ! kidney mesenchyme development created_by: midori creation_date: 2010-01-25T04:35:36Z [Term] id: GO:0072073 name: kidney epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T04:37:42Z [Term] id: GO:0072074 name: kidney mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-01-25T04:39:04Z [Term] id: GO:0072075 name: metanephric mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-01-25T04:40:11Z [Term] id: GO:0072076 name: nephrogenic mesenchyme development namespace: biological_process def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072074 ! kidney mesenchyme development relationship: part_of GO:0072006 ! nephron development created_by: midori creation_date: 2010-01-25T04:40:44Z [Term] id: GO:0072077 name: renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0072087 ! renal vesicle development relationship: part_of GO:0072088 ! nephron epithelium morphogenesis created_by: midori creation_date: 2010-02-01T02:21:06Z [Term] id: GO:0072078 name: nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061333 ! renal tubule morphogenesis is_a: GO:0072088 ! nephron epithelium morphogenesis relationship: part_of GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-02-01T02:25:14Z [Term] id: GO:0072079 name: nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0072078 ! nephron tubule morphogenesis created_by: midori creation_date: 2010-02-01T02:29:26Z [Term] id: GO:0072080 name: nephron tubule development namespace: biological_process def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0061326 ! renal tubule development is_a: GO:0072009 ! nephron epithelium development created_by: midori creation_date: 2010-02-01T02:32:12Z [Term] id: GO:0072081 name: specification of nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0007379 ! segment specification is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development relationship: part_of GO:0072079 ! nephron tubule formation created_by: midori creation_date: 2010-02-01T02:42:34Z [Term] id: GO:0072082 name: specification of proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072158 ! proximal tubule morphogenesis created_by: midori creation_date: 2010-02-01T02:44:34Z [Term] id: GO:0072084 name: specification of distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072156 ! distal tubule morphogenesis created_by: midori creation_date: 2010-02-01T02:47:53Z [Term] id: GO:0072085 name: specification of connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072027 ! connecting tubule development created_by: midori creation_date: 2010-02-01T02:49:11Z [Term] id: GO:0072086 name: specification of loop of Henle identity namespace: biological_process alt_id: GO:0072083 def: "The process in which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "specification of intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072070 ! loop of Henle development created_by: midori creation_date: 2010-02-01T02:49:35Z [Term] id: GO:0072087 name: renal vesicle development namespace: biological_process def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0072009 ! nephron epithelium development created_by: midori creation_date: 2010-02-08T01:18:31Z [Term] id: GO:0072088 name: nephron epithelium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0072009 ! nephron epithelium development relationship: part_of GO:0072028 ! nephron morphogenesis created_by: midori creation_date: 2010-02-08T01:19:06Z [Term] id: GO:0072089 name: stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell population proliferation relationship: has_part GO:0017145 ! stem cell division created_by: midori creation_date: 2010-02-08T02:03:36Z [Term] id: GO:0072090 name: mesenchymal stem cell proliferation involved in nephron morphogenesis namespace: biological_process def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] is_a: GO:0097168 ! mesenchymal stem cell proliferation created_by: midori creation_date: 2010-02-08T02:05:54Z [Term] id: GO:0072091 name: regulation of stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072089 ! stem cell proliferation relationship: regulates GO:0072089 ! stem cell proliferation created_by: midori creation_date: 2010-02-08T02:09:03Z [Term] id: GO:0072092 name: ureteric bud invasion namespace: biological_process def: "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060677 ! ureteric bud elongation relationship: part_of GO:0072093 ! metanephric renal vesicle formation created_by: midori creation_date: 2010-02-10T01:15:13Z [Term] id: GO:0072093 name: metanephric renal vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072033 ! renal vesicle formation relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis created_by: midori creation_date: 2010-02-10T01:17:11Z [Term] id: GO:0072094 name: metanephric renal vesicle induction namespace: biological_process def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] synonym: "positive regulation of metanephros formation" BROAD [GOC:mtg_kidney_jan10] is_a: GO:0072034 ! renal vesicle induction is_a: GO:0072216 ! positive regulation of metanephros development relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation created_by: midori creation_date: 2010-02-10T01:23:20Z [Term] id: GO:0072095 name: regulation of branch elongation involved in ureteric bud branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060681 ! branch elongation involved in ureteric bud branching relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching created_by: midori creation_date: 2010-02-10T01:41:18Z [Term] id: GO:0072096 name: negative regulation of branch elongation involved in ureteric bud branching namespace: biological_process def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching is_a: GO:0090191 ! negative regulation of branching involved in ureteric bud morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching created_by: midori creation_date: 2010-02-10T01:52:09Z [Term] id: GO:0072097 name: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] synonym: "negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0072096 ! negative regulation of branch elongation involved in ureteric bud branching intersection_of: GO:0030509 ! BMP signaling pathway intersection_of: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching created_by: midori creation_date: 2010-02-10T02:00:34Z [Term] id: GO:0072098 name: anterior/posterior pattern specification involved in kidney development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-02-10T02:06:24Z [Term] id: GO:0072099 name: anterior/posterior pattern specification involved in ureteric bud development namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development intersection_of: GO:0009952 ! anterior/posterior pattern specification intersection_of: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0001657 ! ureteric bud development created_by: midori creation_date: 2010-02-10T02:12:09Z [Term] id: GO:0072100 name: specification of ureteric bud anterior/posterior symmetry namespace: biological_process def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] synonym: "specification of ureteric bud anterior/posterior asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry is_a: GO:0072099 ! anterior/posterior pattern specification involved in ureteric bud development created_by: midori creation_date: 2010-02-10T02:18:16Z [Term] id: GO:0072101 name: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] synonym: "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway" EXACT [GOC:dph] synonym: "specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:0061216 ! regulation of transcription from RNA polymerase II promoter involved in mesonephros development is_a: GO:0072100 ! specification of ureteric bud anterior/posterior symmetry created_by: midori creation_date: 2010-02-10T02:21:03Z [Term] id: GO:0072102 name: glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032835 ! glomerulus development created_by: midori creation_date: 2010-02-10T02:32:09Z [Term] id: GO:0072103 name: glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061439 ! kidney vasculature morphogenesis relationship: part_of GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0072102 ! glomerulus morphogenesis created_by: midori creation_date: 2010-02-10T02:34:54Z [Term] id: GO:0072104 name: glomerular capillary formation namespace: biological_process def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0001525 ! angiogenesis relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis created_by: midori creation_date: 2010-02-10T02:40:40Z [Term] id: GO:0072105 name: ureteric peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0014849 ! ureter smooth muscle contraction is_a: GO:0030432 ! peristalsis created_by: midori creation_date: 2010-02-10T03:07:54Z [Term] id: GO:0072106 name: regulation of ureteric bud formation namespace: biological_process def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060676 ! ureteric bud formation relationship: regulates GO:0060676 ! ureteric bud formation created_by: midori creation_date: 2010-02-12T02:34:40Z [Term] id: GO:0072107 name: positive regulation of ureteric bud formation namespace: biological_process def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0072106 ! regulation of ureteric bud formation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905278 ! positive regulation of epithelial tube formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060676 ! ureteric bud formation relationship: positively_regulates GO:0060676 ! ureteric bud formation created_by: midori creation_date: 2010-02-12T02:37:28Z [Term] id: GO:0072108 name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis created_by: midori creation_date: 2010-02-12T02:45:57Z [Term] id: GO:0072109 name: glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0072012 ! glomerulus vasculature development created_by: midori creation_date: 2010-02-22T10:35:24Z [Term] id: GO:0072110 name: glomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072109 ! glomerular mesangium development created_by: midori creation_date: 2010-02-22T10:45:47Z [Term] id: GO:0072111 name: cell proliferation involved in kidney development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-02-22T10:48:45Z [Term] id: GO:0072112 name: glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061318 ! renal filtration cell differentiation is_a: GO:0072311 ! glomerular epithelial cell differentiation created_by: midori creation_date: 2010-02-22T10:52:11Z [Term] id: GO:0072113 name: head kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0048534 ! hematopoietic or lymphoid organ development is_a: GO:0048793 ! pronephros development created_by: midori creation_date: 2010-02-22T11:09:38Z [Term] id: GO:0072114 name: pronephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0048793 ! pronephros development created_by: midori creation_date: 2010-02-22T11:12:15Z [Term] id: GO:0072115 name: head kidney morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072114 ! pronephros morphogenesis relationship: part_of GO:0072113 ! head kidney development created_by: midori creation_date: 2010-02-22T11:13:37Z [Term] id: GO:0072116 name: pronephros formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048645 ! animal organ formation is_a: GO:0072003 ! kidney rudiment formation relationship: part_of GO:0072114 ! pronephros morphogenesis created_by: midori creation_date: 2010-02-22T11:16:26Z [Term] id: GO:0072117 name: head kidney formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072116 ! pronephros formation relationship: part_of GO:0072115 ! head kidney morphogenesis created_by: midori creation_date: 2010-02-22T11:17:20Z [Term] id: GO:0072118 name: pronephros structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney structural organization" EXACT [GOC:mtg_kidney_jan10] synonym: "pronephros structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0072114 ! pronephros morphogenesis created_by: midori creation_date: 2010-02-22T11:21:38Z [Term] id: GO:0072119 name: head kidney structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] synonym: "head kidney structural organisation" EXACT [GOC:mah] is_a: GO:0072118 ! pronephros structural organization relationship: part_of GO:0072115 ! head kidney morphogenesis created_by: midori creation_date: 2010-02-22T11:22:12Z [Term] id: GO:0072120 name: pronephros maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048799 ! animal organ maturation relationship: part_of GO:0048793 ! pronephros development created_by: midori creation_date: 2010-02-22T11:25:48Z [Term] id: GO:0072121 name: head kidney maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] is_a: GO:0072120 ! pronephros maturation relationship: part_of GO:0072113 ! head kidney development created_by: midori creation_date: 2010-02-22T11:28:08Z [Term] id: GO:0072122 name: extraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072006 ! nephron development created_by: midori creation_date: 2010-02-22T01:42:23Z [Term] id: GO:0072123 name: intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0072110 ! glomerular mesangial cell proliferation created_by: midori creation_date: 2010-02-22T01:44:29Z [Term] id: GO:0072124 name: regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0090192 ! regulation of glomerulus development is_a: GO:1901342 ! regulation of vasculature development is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072110 ! glomerular mesangial cell proliferation relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation created_by: midori creation_date: 2010-02-22T01:46:12Z [Term] id: GO:0072125 name: negative regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:0090194 ! negative regulation of glomerulus development is_a: GO:1901343 ! negative regulation of vasculature development is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation created_by: midori creation_date: 2010-02-22T01:48:49Z [Term] id: GO:0072126 name: positive regulation of glomerular mesangial cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:0090193 ! positive regulation of glomerulus development is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation created_by: midori creation_date: 2010-02-22T01:49:31Z [Term] id: GO:0072127 name: renal capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-02-22T02:02:55Z [Term] id: GO:0072128 name: renal capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0072127 ! renal capsule development created_by: midori creation_date: 2010-02-22T02:06:19Z [Term] id: GO:0072129 name: renal capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072128 ! renal capsule morphogenesis created_by: midori creation_date: 2010-02-22T02:08:14Z [Term] id: GO:0072130 name: renal capsule specification namespace: biological_process def: "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0003002 ! regionalization is_a: GO:0061004 ! pattern specification involved in kidney development relationship: part_of GO:0072129 ! renal capsule formation created_by: midori creation_date: 2010-02-22T02:12:34Z [Term] id: GO:0072131 name: kidney mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0072074 ! kidney mesenchyme development created_by: midori creation_date: 2010-02-22T02:16:43Z [Term] id: GO:0072132 name: mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0060485 ! mesenchyme development created_by: midori creation_date: 2010-02-22T02:17:15Z [Term] id: GO:0072133 name: metanephric mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0072075 ! metanephric mesenchyme development created_by: midori creation_date: 2010-02-22T02:20:14Z [Term] id: GO:0072134 name: nephrogenic mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] is_a: GO:0072131 ! kidney mesenchyme morphogenesis relationship: part_of GO:0072076 ! nephrogenic mesenchyme development created_by: midori creation_date: 2010-02-22T02:21:16Z [Term] id: GO:0072135 name: kidney mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0072111 ! cell proliferation involved in kidney development relationship: part_of GO:0072074 ! kidney mesenchyme development created_by: midori creation_date: 2010-02-22T02:33:10Z [Term] id: GO:0072136 name: metanephric mesenchymal cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10] is_a: GO:0072135 ! kidney mesenchymal cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072075 ! metanephric mesenchyme development created_by: midori creation_date: 2010-02-22T02:34:56Z [Term] id: GO:0072137 name: condensed mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation created_by: midori creation_date: 2010-02-22T02:38:54Z [Term] id: GO:0072138 name: mesenchymal cell proliferation involved in ureteric bud development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10] synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0061209 ! cell proliferation involved in mesonephros development intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: part_of GO:0001657 ! ureteric bud development relationship: part_of GO:0001657 ! ureteric bud development created_by: midori creation_date: 2010-02-22T02:40:38Z [Term] id: GO:0072139 name: glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0072311 ! glomerular epithelial cell differentiation created_by: midori creation_date: 2010-02-24T01:33:05Z [Term] id: GO:0072140 name: DCT cell development namespace: biological_process def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072069 ! DCT cell differentiation created_by: midori creation_date: 2010-02-24T01:36:21Z [Term] id: GO:0072141 name: renal interstitial fibroblast development namespace: biological_process def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation created_by: midori creation_date: 2010-02-24T01:39:05Z [Term] id: GO:0072142 name: juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation created_by: midori creation_date: 2010-02-24T01:42:53Z [Term] id: GO:0072143 name: mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072007 ! mesangial cell differentiation created_by: midori creation_date: 2010-02-24T01:44:28Z [Term] id: GO:0072144 name: glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development is_a: GO:0072143 ! mesangial cell development relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation created_by: midori creation_date: 2010-02-24T01:53:13Z [Term] id: GO:0072145 name: proximal convoluted tubule segment 1 cell development namespace: biological_process def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0048468 ! cell development relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation created_by: midori creation_date: 2010-02-24T01:54:56Z [Term] id: GO:0072146 name: DCT cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10] synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072069 ! DCT cell differentiation created_by: midori creation_date: 2010-02-24T01:59:04Z [Term] id: GO:0072147 name: glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072148 ! epithelial cell fate commitment is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation created_by: midori creation_date: 2010-02-24T02:00:52Z [Term] id: GO:0072148 name: epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030855 ! epithelial cell differentiation created_by: midori creation_date: 2010-02-24T02:05:03Z [Term] id: GO:0072149 name: glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] synonym: "podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072148 ! epithelial cell fate commitment is_a: GO:0072314 ! glomerular epithelial cell fate commitment relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation created_by: midori creation_date: 2010-02-24T02:08:03Z [Term] id: GO:0072150 name: juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation created_by: midori creation_date: 2010-02-24T02:09:49Z [Term] id: GO:0072151 name: mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072007 ! mesangial cell differentiation created_by: midori creation_date: 2010-02-24T02:11:13Z [Term] id: GO:0072152 name: glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072151 ! mesangial cell fate commitment relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation created_by: midori creation_date: 2010-02-24T02:14:58Z [Term] id: GO:0072153 name: renal interstitial fibroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast." [GOC:mtg_kidney_jan10] synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation created_by: midori creation_date: 2010-02-24T02:16:53Z [Term] id: GO:0072154 name: proximal convoluted tubule segment 1 cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "S1 cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation created_by: midori creation_date: 2010-02-24T02:18:19Z [Term] id: GO:0072155 name: epithelial cell migration involved in nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0035787 ! cell migration involved in kidney development intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072078 ! nephron tubule morphogenesis created_by: midori creation_date: 2010-02-24T02:21:25Z [Term] id: GO:0072156 name: distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072017 ! distal tubule development created_by: midori creation_date: 2010-02-24T02:32:03Z [Term] id: GO:0072157 name: epithelial cell migration involved in distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072156 ! distal tubule morphogenesis relationship: part_of GO:0072156 ! distal tubule morphogenesis created_by: midori creation_date: 2010-02-24T02:33:33Z [Term] id: GO:0072158 name: proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072014 ! proximal tubule development created_by: midori creation_date: 2010-02-24T02:35:36Z [Term] id: GO:0072159 name: epithelial cell migration involved in proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072158 ! proximal tubule morphogenesis relationship: part_of GO:0072158 ! proximal tubule morphogenesis created_by: midori creation_date: 2010-02-24T02:37:08Z [Term] id: GO:0072160 name: nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: part_of GO:0072080 ! nephron tubule development created_by: midori creation_date: 2010-02-24T02:40:11Z [Term] id: GO:0072161 name: mesenchymal cell differentiation involved in kidney development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0001822 ! kidney development relationship: part_of GO:0072074 ! kidney mesenchyme development created_by: midori creation_date: 2010-02-26T01:31:49Z [Term] id: GO:0072162 name: metanephric mesenchymal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072075 ! metanephric mesenchyme development created_by: midori creation_date: 2010-02-26T01:35:00Z [Term] id: GO:0072163 name: mesonephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0001823 ! mesonephros development created_by: midori creation_date: 2010-02-26T01:40:43Z [Term] id: GO:0072164 name: mesonephric tubule development namespace: biological_process def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072163 ! mesonephric epithelium development created_by: midori creation_date: 2010-02-26T01:45:58Z [Term] id: GO:0072165 name: anterior mesonephric tubule development namespace: biological_process def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072164 ! mesonephric tubule development created_by: midori creation_date: 2010-02-26T01:47:26Z [Term] id: GO:0072166 name: posterior mesonephric tubule development namespace: biological_process def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072164 ! mesonephric tubule development created_by: midori creation_date: 2010-02-26T01:47:50Z [Term] id: GO:0072167 name: specification of mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0061227 ! pattern specification involved in mesonephros development is_a: GO:0072081 ! specification of nephron tubule identity relationship: part_of GO:0072172 ! mesonephric tubule formation created_by: midori creation_date: 2010-02-26T01:51:03Z [Term] id: GO:0072168 name: specification of anterior mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development is_a: GO:0072167 ! specification of mesonephric tubule identity relationship: part_of GO:0072165 ! anterior mesonephric tubule development created_by: midori creation_date: 2010-02-26T01:52:36Z [Term] id: GO:0072169 name: specification of posterior mesonephric tubule identity namespace: biological_process def: "The process in which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development is_a: GO:0072167 ! specification of mesonephric tubule identity relationship: part_of GO:0072166 ! posterior mesonephric tubule development created_by: midori creation_date: 2010-02-26T01:54:06Z [Term] id: GO:0072170 name: metanephric tubule development namespace: biological_process def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072207 ! metanephric epithelium development created_by: midori creation_date: 2010-02-26T01:58:18Z [Term] id: GO:0072171 name: mesonephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis relationship: part_of GO:0072164 ! mesonephric tubule development created_by: midori creation_date: 2010-02-26T02:02:13Z [Term] id: GO:0072172 name: mesonephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis created_by: midori creation_date: 2010-02-26T02:02:37Z [Term] id: GO:0072173 name: metanephric tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0072170 ! metanephric tubule development created_by: midori creation_date: 2010-02-26T02:06:42Z [Term] id: GO:0072174 name: metanephric tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0072173 ! metanephric tubule morphogenesis created_by: midori creation_date: 2010-02-26T02:07:41Z [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation relationship: part_of GO:0060562 ! epithelial tube morphogenesis created_by: midori creation_date: 2010-02-26T02:15:40Z [Term] id: GO:0072176 name: nephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0072073 ! kidney epithelium development created_by: midori creation_date: 2010-02-26T02:27:31Z [Term] id: GO:0072177 name: mesonephric duct development namespace: biological_process def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct development" EXACT [GOC:dph] is_a: GO:0072164 ! mesonephric tubule development is_a: GO:0072176 ! nephric duct development created_by: midori creation_date: 2010-02-26T02:32:22Z [Term] id: GO:0072178 name: nephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0072176 ! nephric duct development created_by: midori creation_date: 2010-02-26T02:35:29Z [Term] id: GO:0072179 name: nephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0072178 ! nephric duct morphogenesis created_by: midori creation_date: 2010-02-26T02:35:55Z [Term] id: GO:0072180 name: mesonephric duct morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph] is_a: GO:0072171 ! mesonephric tubule morphogenesis is_a: GO:0072178 ! nephric duct morphogenesis relationship: part_of GO:0072177 ! mesonephric duct development created_by: midori creation_date: 2010-02-26T02:37:13Z [Term] id: GO:0072181 name: mesonephric duct formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10] synonym: "Wolffian duct formation" EXACT [GOC:dph] is_a: GO:0072172 ! mesonephric tubule formation is_a: GO:0072179 ! nephric duct formation is_a: GO:0072180 ! mesonephric duct morphogenesis created_by: midori creation_date: 2010-02-26T02:38:03Z [Term] id: GO:0072182 name: regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072160 ! nephron tubule epithelial cell differentiation relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation created_by: midori creation_date: 2010-02-26T02:45:09Z [Term] id: GO:0072183 name: negative regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation created_by: midori creation_date: 2010-02-26T02:47:25Z [Term] id: GO:0072184 name: renal vesicle progenitor cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072087 ! renal vesicle development created_by: midori creation_date: 2010-02-26T02:52:54Z [Term] id: GO:0072185 name: metanephric cap development namespace: biological_process def: "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0072075 ! metanephric mesenchyme development created_by: midori creation_date: 2010-03-01T01:20:22Z [Term] id: GO:0072186 name: metanephric cap morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0072133 ! metanephric mesenchyme morphogenesis relationship: part_of GO:0072185 ! metanephric cap development created_by: midori creation_date: 2010-03-01T01:22:51Z [Term] id: GO:0072187 name: metanephric cap formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0072186 ! metanephric cap morphogenesis created_by: midori creation_date: 2010-03-01T01:26:53Z [Term] id: GO:0072188 name: metanephric cap specification namespace: biological_process def: "The process in which the metanephric cap acquires its identity." [GOC:mtg_kidney_jan10] is_a: GO:0072048 ! renal system pattern specification is_a: GO:0072187 ! metanephric cap formation is_a: GO:0072268 ! pattern specification involved in metanephros development created_by: midori creation_date: 2010-03-01T01:35:25Z [Term] id: GO:0072189 name: ureter development namespace: biological_process def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development created_by: midori creation_date: 2010-03-01T01:44:14Z [Term] id: GO:0072190 name: ureter urothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0072189 ! ureter development created_by: midori creation_date: 2010-03-01T01:46:31Z [Term] id: GO:0072191 name: ureter smooth muscle development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0072189 ! ureter development created_by: midori creation_date: 2010-03-01T01:48:53Z [Term] id: GO:0072192 name: ureter epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0072190 ! ureter urothelium development created_by: midori creation_date: 2010-03-01T01:53:17Z [Term] id: GO:0072193 name: ureter smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0072191 ! ureter smooth muscle development created_by: midori creation_date: 2010-03-01T01:55:01Z [Term] id: GO:0072194 name: kidney smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0048745 ! smooth muscle tissue development relationship: part_of GO:0001822 ! kidney development created_by: midori creation_date: 2010-03-01T02:05:30Z [Term] id: GO:0072195 name: kidney smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0051145 ! smooth muscle cell differentiation is_a: GO:0061005 ! cell differentiation involved in kidney development relationship: part_of GO:0072194 ! kidney smooth muscle tissue development created_by: midori creation_date: 2010-03-01T02:07:52Z [Term] id: GO:0072196 name: proximal/distal pattern formation involved in pronephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros." [GOC:mtg_kidney_jan10] synonym: "pronephros proximal/distal pattern formation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0039017 ! pattern specification involved in pronephros development is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development intersection_of: GO:0009954 ! proximal/distal pattern formation intersection_of: part_of GO:0039019 ! pronephric nephron development relationship: part_of GO:0039019 ! pronephric nephron development created_by: midori creation_date: 2010-03-01T02:11:07Z [Term] id: GO:0072197 name: ureter morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0072189 ! ureter development created_by: midori creation_date: 2010-03-01T02:24:55Z [Term] id: GO:0072198 name: mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10] synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: part_of GO:0072189 ! ureter development relationship: part_of GO:0072189 ! ureter development created_by: midori creation_date: 2010-03-01T03:24:41Z [Term] id: GO:0072199 name: regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development created_by: midori creation_date: 2010-03-01T03:38:13Z [Term] id: GO:0072200 name: negative regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development created_by: midori creation_date: 2010-03-01T03:42:31Z [Term] id: GO:0072201 name: negative regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010463 ! mesenchymal cell proliferation relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation created_by: midori creation_date: 2010-03-01T03:43:29Z [Term] id: GO:0072202 name: cell differentiation involved in metanephros development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10] is_a: GO:0061005 ! cell differentiation involved in kidney development intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T10:40:14Z [Term] id: GO:0072203 name: cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072111 ! cell proliferation involved in kidney development intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T10:42:27Z [Term] id: GO:0072204 name: cell-cell signaling involved in metanephros development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah] is_a: GO:0060995 ! cell-cell signaling involved in kidney development intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T10:54:36Z [Term] id: GO:0072205 name: metanephric collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] is_a: GO:0072044 ! collecting duct development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T11:15:37Z [Term] id: GO:0072206 name: metanephric juxtaglomerular apparatus development namespace: biological_process def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] is_a: GO:0072051 ! juxtaglomerular apparatus development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T11:17:47Z [Term] id: GO:0072207 name: metanephric epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] is_a: GO:0072073 ! kidney epithelium development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T11:50:37Z [Term] id: GO:0072208 name: metanephric smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072194 ! kidney smooth muscle tissue development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T11:51:59Z [Term] id: GO:0072209 name: metanephric mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072007 ! mesangial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development created_by: midori creation_date: 2010-03-18T11:56:44Z [Term] id: GO:0072210 name: metanephric nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] is_a: GO:0072006 ! nephron development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T12:52:57Z [Term] id: GO:0072211 name: metanephric pyramids development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] synonym: "metanephric kidney pyramid development" EXACT [GOC:mah] synonym: "metanephric pyramid development" EXACT [GOC:mah] synonym: "metanephric renal medulla development" EXACT [GOC:mah] synonym: "metanephric renal pyramid development" EXACT [GOC:mah] is_a: GO:0072056 ! pyramid development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:04:51Z [Term] id: GO:0072212 name: regulation of transcription from RNA polymerase II promoter involved in metanephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:14:09Z [Term] id: GO:0072213 name: metanephric capsule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072127 ! renal capsule development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:25:19Z [Term] id: GO:0072214 name: metanephric cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0060485 ! mesenchyme development is_a: GO:0072055 ! renal cortex development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:29:49Z [Term] id: GO:0072215 name: regulation of metanephros development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001656 ! metanephros development relationship: regulates GO:0001656 ! metanephros development [Term] id: GO:0072216 name: positive regulation of metanephros development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090184 ! positive regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001656 ! metanephros development relationship: positively_regulates GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:40:12Z [Term] id: GO:0072217 name: negative regulation of metanephros development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090185 ! negative regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001656 ! metanephros development relationship: negatively_regulates GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-18T01:45:48Z [Term] id: GO:0072218 name: metanephric ascending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] is_a: GO:0072021 ! ascending thin limb development is_a: GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072236 ! metanephric loop of Henle development created_by: midori creation_date: 2010-03-18T03:34:42Z [Term] id: GO:0072219 name: metanephric cortical collecting duct development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] is_a: GO:0072059 ! cortical collecting duct development created_by: midori creation_date: 2010-03-18T03:34:52Z [Term] id: GO:0072220 name: metanephric descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10] is_a: GO:0072022 ! descending thin limb development relationship: part_of GO:0072236 ! metanephric loop of Henle development created_by: midori creation_date: 2010-03-18T03:35:05Z [Term] id: GO:0072221 name: metanephric distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] is_a: GO:0072025 ! distal convoluted tubule development is_a: GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072235 ! metanephric distal tubule development created_by: midori creation_date: 2010-03-18T03:35:27Z [Term] id: GO:0072222 name: metanephric early distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072067 ! early distal convoluted tubule development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development created_by: midori creation_date: 2010-03-18T03:35:46Z [Term] id: GO:0072223 name: metanephric glomerular mesangium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072109 ! glomerular mesangium development relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development created_by: midori creation_date: 2010-03-18T03:35:56Z [Term] id: GO:0072224 name: metanephric glomerulus development namespace: biological_process def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah] synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0032835 ! glomerulus development relationship: part_of GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-18T03:36:20Z [Term] id: GO:0072225 name: metanephric late distal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] is_a: GO:0072068 ! late distal convoluted tubule development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development created_by: midori creation_date: 2010-03-18T03:37:04Z [Term] id: GO:0072226 name: metanephric long descending thin limb bend development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072065 ! long descending thin limb bend development relationship: part_of GO:0072220 ! metanephric descending thin limb development relationship: part_of GO:0072269 ! metanephric long descending thin limb development created_by: midori creation_date: 2010-03-18T03:37:16Z [Term] id: GO:0072227 name: metanephric macula densa development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072024 ! macula densa development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development created_by: midori creation_date: 2010-03-18T03:37:26Z [Term] id: GO:0072228 name: metanephric prebend segment development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] is_a: GO:0072066 ! prebend segment development relationship: part_of GO:0072220 ! metanephric descending thin limb development created_by: midori creation_date: 2010-03-18T03:37:46Z [Term] id: GO:0072229 name: metanephric proximal convoluted tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072019 ! proximal convoluted tubule development is_a: GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072237 ! metanephric proximal tubule development created_by: midori creation_date: 2010-03-18T03:37:56Z [Term] id: GO:0072230 name: metanephric proximal straight tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072020 ! proximal straight tubule development is_a: GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072237 ! metanephric proximal tubule development created_by: midori creation_date: 2010-03-18T03:38:53Z [Term] id: GO:0072231 name: metanephric proximal convoluted tubule segment 1 development namespace: biological_process def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072031 ! proximal convoluted tubule segment 1 development relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development created_by: midori creation_date: 2010-03-18T03:39:10Z [Term] id: GO:0072232 name: metanephric proximal convoluted tubule segment 2 development namespace: biological_process def: "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "metanephric S2 development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072032 ! proximal convoluted tubule segment 2 development relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development created_by: midori creation_date: 2010-03-18T03:39:28Z [Term] id: GO:0072233 name: metanephric thick ascending limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072023 ! thick ascending limb development is_a: GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072235 ! metanephric distal tubule development created_by: midori creation_date: 2010-03-18T03:39:36Z [Term] id: GO:0072234 name: metanephric nephron tubule development namespace: biological_process def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072080 ! nephron tubule development is_a: GO:0072170 ! metanephric tubule development is_a: GO:0072243 ! metanephric nephron epithelium development created_by: midori creation_date: 2010-03-18T03:41:23Z [Term] id: GO:0072235 name: metanephric distal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072017 ! distal tubule development is_a: GO:0072234 ! metanephric nephron tubule development created_by: midori creation_date: 2010-03-18T03:45:37Z [Term] id: GO:0072236 name: metanephric loop of Henle development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric intermediate tubule development" EXACT [] is_a: GO:0072070 ! loop of Henle development is_a: GO:0072234 ! metanephric nephron tubule development created_by: midori creation_date: 2010-03-18T03:46:18Z [Term] id: GO:0072237 name: metanephric proximal tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072014 ! proximal tubule development is_a: GO:0072234 ! metanephric nephron tubule development created_by: midori creation_date: 2010-03-18T03:46:54Z [Term] id: GO:0072238 name: metanephric long nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072029 ! long nephron development is_a: GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-18T03:48:23Z [Term] id: GO:0072239 name: metanephric glomerulus vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072012 ! glomerulus vasculature development relationship: part_of GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-03-18T03:50:29Z [Term] id: GO:0072240 name: metanephric DCT cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072069 ! DCT cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development created_by: midori creation_date: 2010-03-19T03:24:25Z [Term] id: GO:0072241 name: metanephric DCT cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072140 ! DCT cell development relationship: part_of GO:0072240 ! metanephric DCT cell differentiation created_by: midori creation_date: 2010-03-19T03:26:44Z [Term] id: GO:0072242 name: metanephric DCT cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell." [GOC:mtg_kidney_jan10] synonym: "metanephric distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072146 ! DCT cell fate commitment relationship: part_of GO:0072240 ! metanephric DCT cell differentiation created_by: midori creation_date: 2010-03-19T03:27:00Z [Term] id: GO:0072243 name: metanephric nephron epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072009 ! nephron epithelium development is_a: GO:0072207 ! metanephric epithelium development created_by: midori creation_date: 2010-03-19T03:29:49Z [Term] id: GO:0072244 name: metanephric glomerular epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072010 ! glomerular epithelium development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-03-19T03:38:47Z [Term] id: GO:0072245 name: metanephric glomerular parietal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:41:26Z [Term] id: GO:0072246 name: metanephric glomerular parietal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] synonym: "metanephric Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072016 ! glomerular parietal epithelial cell development is_a: GO:0072313 ! metanephric glomerular epithelial cell development relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:42:13Z [Term] id: GO:0072247 name: metanephric glomerular parietal epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] synonym: "metanephric Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:42:27Z [Term] id: GO:0072248 name: metanephric glomerular visceral epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:44:57Z [Term] id: GO:0072249 name: metanephric glomerular visceral epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072015 ! glomerular visceral epithelial cell development is_a: GO:0072313 ! metanephric glomerular epithelial cell development relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:46:26Z [Term] id: GO:0072250 name: metanephric glomerular visceral epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation created_by: midori creation_date: 2010-03-19T03:46:41Z [Term] id: GO:0072251 name: metanephric juxtaglomerulus cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072052 ! juxtaglomerulus cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development created_by: midori creation_date: 2010-03-19T03:54:35Z [Term] id: GO:0072252 name: metanephric juxtaglomerulus cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072142 ! juxtaglomerulus cell development relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation created_by: midori creation_date: 2010-03-19T03:55:31Z [Term] id: GO:0072253 name: metanephric juxtaglomerulus cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] is_a: GO:0072150 ! juxtaglomerulus cell fate commitment relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation created_by: midori creation_date: 2010-03-19T03:55:47Z [Term] id: GO:0072254 name: metanephric glomerular mesangial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072008 ! glomerular mesangial cell differentiation is_a: GO:0072209 ! metanephric mesangial cell differentiation relationship: part_of GO:0072223 ! metanephric glomerular mesangium development created_by: midori creation_date: 2010-03-19T04:04:02Z [Term] id: GO:0072255 name: metanephric glomerular mesangial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] is_a: GO:0072144 ! glomerular mesangial cell development relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation created_by: midori creation_date: 2010-03-19T04:06:58Z [Term] id: GO:0072256 name: metanephric glomerular mesangial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] is_a: GO:0072152 ! glomerular mesangial cell fate commitment relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation created_by: midori creation_date: 2010-03-19T04:07:10Z [Term] id: GO:0072257 name: metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] is_a: GO:0072160 ! nephron tubule epithelial cell differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072234 ! metanephric nephron tubule development created_by: midori creation_date: 2010-03-19T04:11:02Z [Term] id: GO:0072258 name: metanephric interstitial fibroblast differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072071 ! kidney interstitial fibroblast differentiation is_a: GO:0072202 ! cell differentiation involved in metanephros development created_by: midori creation_date: 2010-03-19T04:17:32Z [Term] id: GO:0072259 name: metanephric interstitial fibroblast development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072141 ! renal interstitial fibroblast development relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation created_by: midori creation_date: 2010-03-19T04:18:00Z [Term] id: GO:0072260 name: metanephric interstitial fibroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast." [GOC:mtg_kidney_jan10] synonym: "metanephros interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072153 ! renal interstitial fibroblast fate commitment relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation created_by: midori creation_date: 2010-03-19T04:18:10Z [Term] id: GO:0072261 name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] synonym: "metanephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] synonym: "metanephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0072122 ! extraglomerular mesangial cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-30T02:14:17Z [Term] id: GO:0072262 name: metanephric glomerular mesangial cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] is_a: GO:0072110 ! glomerular mesangial cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072223 ! metanephric glomerular mesangium development created_by: midori creation_date: 2010-03-30T02:27:27Z [Term] id: GO:0072263 name: metanephric intraglomerular mesangial cell proliferation namespace: biological_process def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] is_a: GO:0072123 ! intraglomerular mesangial cell proliferation is_a: GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development created_by: midori creation_date: 2010-03-30T02:27:53Z [Term] id: GO:0072264 name: metanephric glomerular endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072011 ! glomerular endothelium development is_a: GO:0072244 ! metanephric glomerular epithelium development relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development created_by: midori creation_date: 2010-03-30T02:42:26Z [Term] id: GO:0072265 name: metanephric capsule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072128 ! renal capsule morphogenesis relationship: part_of GO:0072213 ! metanephric capsule development created_by: midori creation_date: 2010-03-30T02:54:49Z [Term] id: GO:0072266 name: metanephric capsule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] is_a: GO:0072129 ! renal capsule formation relationship: part_of GO:0072265 ! metanephric capsule morphogenesis created_by: midori creation_date: 2010-03-30T02:56:35Z [Term] id: GO:0072267 name: metanephric capsule specification namespace: biological_process def: "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] is_a: GO:0072130 ! renal capsule specification is_a: GO:0072268 ! pattern specification involved in metanephros development relationship: part_of GO:0072266 ! metanephric capsule formation created_by: midori creation_date: 2010-03-30T02:57:36Z [Term] id: GO:0072268 name: pattern specification involved in metanephros development namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10] synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10] synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10] is_a: GO:0061004 ! pattern specification involved in kidney development intersection_of: GO:0007389 ! pattern specification process intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: midori creation_date: 2010-03-30T03:06:30Z [Term] id: GO:0072269 name: metanephric long descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] is_a: GO:0072064 ! long descending thin limb development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072238 ! metanephric long nephron development created_by: midori creation_date: 2010-03-30T03:12:05Z [Term] id: GO:0072270 name: metanephric short nephron development namespace: biological_process def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] is_a: GO:0072030 ! short nephron development is_a: GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-30T03:15:18Z [Term] id: GO:0072271 name: metanephric short descending thin limb development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072063 ! short descending thin limb development is_a: GO:0072243 ! metanephric nephron epithelium development relationship: part_of GO:0072270 ! metanephric short nephron development created_by: midori creation_date: 2010-03-30T03:16:25Z [Term] id: GO:0072272 name: proximal/distal pattern formation involved in metanephric nephron development namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] synonym: "proximal-distal pattern formation involved in metanephric nephron development" EXACT [GOC:mtg_kidney_jan10] synonym: "proximal/distal metanephric nephron patterning" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development is_a: GO:0072268 ! pattern specification involved in metanephros development intersection_of: GO:0009954 ! proximal/distal pattern formation intersection_of: part_of GO:0072210 ! metanephric nephron development relationship: part_of GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-30T03:25:37Z [Term] id: GO:0072273 name: metanephric nephron morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072028 ! nephron morphogenesis relationship: part_of GO:0003338 ! metanephros morphogenesis relationship: part_of GO:0072210 ! metanephric nephron development created_by: midori creation_date: 2010-03-30T03:33:19Z [Term] id: GO:0072274 name: metanephric glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] is_a: GO:0032836 ! glomerular basement membrane development relationship: part_of GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-04-01T02:43:51Z [Term] id: GO:0072275 name: metanephric glomerulus morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072102 ! glomerulus morphogenesis relationship: part_of GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-04-01T02:46:58Z [Term] id: GO:0072276 name: metanephric glomerulus vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] is_a: GO:0072103 ! glomerulus vasculature morphogenesis relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development relationship: part_of GO:0072275 ! metanephric glomerulus morphogenesis created_by: midori creation_date: 2010-04-01T02:47:32Z [Term] id: GO:0072277 name: metanephric glomerular capillary formation namespace: biological_process def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] is_a: GO:0072104 ! glomerular capillary formation relationship: part_of GO:0072276 ! metanephric glomerulus vasculature morphogenesis created_by: midori creation_date: 2010-04-01T02:47:56Z [Term] id: GO:0072278 name: metanephric comma-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072049 ! comma-shaped body morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:14:42Z [Term] id: GO:0072279 name: convergent extension involved in metanephric nephron morphogenesis namespace: biological_process def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:16:11Z [Term] id: GO:0072280 name: establishment of planar polarity involved in metanephric nephron morphogenesis namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] synonym: "establishment of planar cell polarity involved in metanephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis intersection_of: GO:0001736 ! establishment of planar polarity intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:17:18Z [Term] id: GO:0072281 name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0061208 ! cell differentiation involved in mesonephros development is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis is_a: GO:0072202 ! cell differentiation involved in metanephros development intersection_of: GO:0072497 ! mesenchymal stem cell differentiation intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:22:06Z [Term] id: GO:0072282 name: metanephric nephron tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072078 ! nephron tubule morphogenesis is_a: GO:0072173 ! metanephric tubule morphogenesis relationship: part_of GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:25:11Z [Term] id: GO:0072283 name: metanephric renal vesicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072077 ! renal vesicle morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:28:00Z [Term] id: GO:0072284 name: metanephric S-shaped body morphogenesis namespace: biological_process def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072050 ! S-shaped body morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-01T03:41:36Z [Term] id: GO:0072285 name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation intersection_of: GO:0060231 ! mesenchymal to epithelial transition intersection_of: part_of GO:0072093 ! metanephric renal vesicle formation relationship: part_of GO:0072093 ! metanephric renal vesicle formation created_by: midori creation_date: 2010-04-01T03:43:31Z [Term] id: GO:0072286 name: metanephric connecting tubule development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10] synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072027 ! connecting tubule development is_a: GO:0072234 ! metanephric nephron tubule development created_by: midori creation_date: 2010-04-09T03:30:09Z [Term] id: GO:0072287 name: metanephric distal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] is_a: GO:0072156 ! distal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis relationship: part_of GO:0072235 ! metanephric distal tubule development created_by: midori creation_date: 2010-04-09T03:41:47Z [Term] id: GO:0072288 name: metanephric proximal tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] is_a: GO:0072158 ! proximal tubule morphogenesis is_a: GO:0072282 ! metanephric nephron tubule morphogenesis relationship: part_of GO:0072237 ! metanephric proximal tubule development created_by: midori creation_date: 2010-04-09T03:42:03Z [Term] id: GO:0072289 name: metanephric nephron tubule formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072079 ! nephron tubule formation is_a: GO:0072174 ! metanephric tubule formation relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis created_by: midori creation_date: 2010-04-09T03:47:44Z [Term] id: GO:0072290 name: epithelial cell migration involved in metanephric nephron tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0035788 ! cell migration involved in metanephros development is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072282 ! metanephric nephron tubule morphogenesis relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis created_by: midori creation_date: 2010-04-09T03:52:29Z [Term] id: GO:0072291 name: epithelial cell migration involved in metanephric distal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072287 ! metanephric distal tubule morphogenesis relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis created_by: midori creation_date: 2010-04-09T03:53:37Z [Term] id: GO:0072292 name: epithelial cell migration involved in metanephric proximal tubule morphogenesis namespace: biological_process def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis intersection_of: GO:0010631 ! epithelial cell migration intersection_of: part_of GO:0072288 ! metanephric proximal tubule morphogenesis relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis created_by: midori creation_date: 2010-04-09T03:54:28Z [Term] id: GO:0072293 name: specification of metanephric nephron tubule identity namespace: biological_process def: "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072081 ! specification of nephron tubule identity is_a: GO:0072268 ! pattern specification involved in metanephros development relationship: part_of GO:0072272 ! proximal/distal pattern formation involved in metanephric nephron development relationship: part_of GO:0072289 ! metanephric nephron tubule formation created_by: midori creation_date: 2010-04-09T03:58:10Z [Term] id: GO:0072294 name: specification of metanephric connecting tubule identity namespace: biological_process def: "The process in which the connecting tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072085 ! specification of connecting tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072286 ! metanephric connecting tubule development created_by: midori creation_date: 2010-04-09T04:00:31Z [Term] id: GO:0072295 name: specification of metanephric distal tubule identity namespace: biological_process def: "The process in which the distal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072084 ! specification of distal tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis created_by: midori creation_date: 2010-04-09T04:01:42Z [Term] id: GO:0072296 name: specification of metanephric loop of Henle identity namespace: biological_process def: "The process in which the loop of Henle of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] synonym: "specification of metanephric intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] is_a: GO:0072086 ! specification of loop of Henle identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072236 ! metanephric loop of Henle development created_by: midori creation_date: 2010-04-09T04:08:05Z [Term] id: GO:0072297 name: specification of metanephric proximal tubule identity namespace: biological_process def: "The process in which the proximal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] is_a: GO:0072082 ! specification of proximal tubule identity is_a: GO:0072293 ! specification of metanephric nephron tubule identity relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis created_by: midori creation_date: 2010-04-09T04:08:20Z [Term] id: GO:0072298 name: regulation of metanephric glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0001656 ! metanephros development is_a: GO:0072215 ! regulation of metanephros development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072224 ! metanephric glomerulus development relationship: regulates GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-04-09T05:03:14Z [Term] id: GO:0072299 name: negative regulation of metanephric glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090194 ! negative regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072224 ! metanephric glomerulus development relationship: negatively_regulates GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072300 name: positive regulation of metanephric glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:0090193 ! positive regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072224 ! metanephric glomerulus development relationship: positively_regulates GO:0072224 ! metanephric glomerulus development created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072301 name: regulation of metanephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:0072298 ! regulation of metanephric glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development relationship: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072302 name: negative regulation of metanephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation is_a: GO:0072299 ! negative regulation of metanephric glomerulus development is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development relationship: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072303 name: positive regulation of glomerular metanephric mesangial cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation is_a: GO:0072300 ! positive regulation of metanephric glomerulus development is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development relationship: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072304 name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072305 name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072306 name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis relationship: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072307 name: regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:0072215 ! regulation of metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072308 name: negative regulation of metanephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072309 name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis namespace: biological_process def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: midori creation_date: 2010-04-09T05:03:41Z [Term] id: GO:0072310 name: glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation created_by: midori creation_date: 2010-04-09T06:47:31Z [Term] id: GO:0072311 name: glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: part_of GO:0072010 ! glomerular epithelium development created_by: midori creation_date: 2010-04-09T06:49:21Z [Term] id: GO:0072312 name: metanephric glomerular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072202 ! cell differentiation involved in metanephros development is_a: GO:0072311 ! glomerular epithelial cell differentiation relationship: part_of GO:0072244 ! metanephric glomerular epithelium development created_by: midori creation_date: 2010-04-09T06:54:15Z [Term] id: GO:0072313 name: metanephric glomerular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072310 ! glomerular epithelial cell development relationship: part_of GO:0072312 ! metanephric glomerular epithelial cell differentiation created_by: midori creation_date: 2010-04-09T06:57:26Z [Term] id: GO:0072314 name: glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation created_by: midori creation_date: 2010-04-09T07:02:25Z [Term] id: GO:0072315 name: metanephric glomerular epithelial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] is_a: GO:0072314 ! glomerular epithelial cell fate commitment created_by: midori creation_date: 2010-04-09T07:03:50Z [Term] id: GO:0072316 name: alpha-glucan catabolic process involved in ascospore release from ascus namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah] synonym: "alpha-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "alpha-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah] synonym: "alpha-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah] is_a: GO:0030980 ! alpha-glucan catabolic process is_a: GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus intersection_of: GO:0030980 ! alpha-glucan catabolic process intersection_of: part_of GO:0071998 ! ascospore release from ascus created_by: midori creation_date: 2010-10-25T05:43:52Z [Term] id: GO:0072317 name: obsolete glucan endo-1,3-beta-D-glucosidase activity involved in ascospore release from ascus namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans that contributes to the release of ascospores from the ascus." [GOC:jl] comment: This term was obsoleted because it should be captured as a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/15204 is_obsolete: true created_by: midori creation_date: 2010-10-25T05:46:13Z [Term] id: GO:0072318 name: clathrin coat disassembly namespace: biological_process def: "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399] synonym: "clathrin-coat disassembly" EXACT [GOC:rb] synonym: "clathrin-coat uncoating" EXACT [GOC:rb] synonym: "clathrin-coated vesicle uncoating" EXACT [GOC:mah] is_a: GO:0072319 ! vesicle uncoating created_by: midori creation_date: 2010-10-26T12:03:37Z [Term] id: GO:0072319 name: vesicle uncoating namespace: biological_process def: "A protein depolymerization process that results in the disassembly of vesicle coat proteins." [GOC:mah] synonym: "vesicle coat disassembly" EXACT [GOC:mah] is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: midori creation_date: 2010-10-26T12:09:21Z [Term] id: GO:0072320 name: volume-sensitive chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah] synonym: "swell-activated chloride channel" RELATED [GOC:sart, PMID:23056495] is_a: GO:0005225 ! volume-sensitive anion channel activity is_a: GO:0005254 ! chloride channel activity created_by: midori creation_date: 2010-10-26T12:53:38Z [Term] id: GO:0072321 name: chaperone-mediated protein transport namespace: biological_process def: "The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773] is_a: GO:0015031 ! protein transport created_by: midori creation_date: 2010-10-28T04:23:20Z [Term] id: GO:0072322 name: protein transport across periplasmic space namespace: biological_process def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall." [GOC:mah] is_a: GO:0015031 ! protein transport created_by: midori creation_date: 2010-10-28T04:24:59Z [Term] id: GO:0072323 name: chaperone-mediated protein transport across periplasmic space namespace: biological_process def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane, mediated by chaperone molecules that bind to the transported proteins. This process has been observed in Gram-negative bacteria." [GOC:mah, PMID:20378773] is_a: GO:0072321 ! chaperone-mediated protein transport is_a: GO:0072322 ! protein transport across periplasmic space created_by: midori creation_date: 2010-10-28T04:26:53Z [Term] id: GO:0072324 name: ascus epiplasm namespace: cellular_component def: "Ascus cytoplasm that is not packaged into ascospores." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mcc] comment: Note that this term is an is_a child of 'cell part' because the epiplasm is extracellular to the spore (each of which is a cell) but within the ascus structure, and originated from cytoplasm. is_a: GO:0110165 ! cellular anatomical entity created_by: midori creation_date: 2010-10-28T04:37:46Z [Term] id: GO:0072325 name: vulval cell fate commitment namespace: biological_process def: "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0040025 ! vulval development created_by: midori creation_date: 2010-11-01T02:02:16Z [Term] id: GO:0072326 name: vulval cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0072325 ! vulval cell fate commitment created_by: midori creation_date: 2010-11-01T02:04:46Z [Term] id: GO:0072327 name: vulval cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0072325 ! vulval cell fate commitment created_by: midori creation_date: 2010-11-01T02:14:06Z [Term] id: GO:0072328 name: alkene binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:mah] is_a: GO:0005488 ! binding created_by: midori creation_date: 2010-11-02T12:39:40Z [Term] id: GO:0072329 name: monocarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process created_by: midori creation_date: 2010-11-02T04:41:55Z [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process created_by: midori creation_date: 2010-11-02T04:51:32Z [Term] id: GO:0072331 name: signal transduction by p53 class mediator namespace: biological_process def: "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction created_by: midori creation_date: 2010-11-03T01:32:59Z [Term] id: GO:0072332 name: intrinsic apoptotic signaling pathway by p53 class mediator namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] synonym: "intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [] synonym: "signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [] is_a: GO:0072331 ! signal transduction by p53 class mediator is_a: GO:0097193 ! intrinsic apoptotic signaling pathway created_by: midori creation_date: 2010-11-03T01:47:56Z [Term] id: GO:0072333 name: obsolete anoikis by p53 class mediator namespace: biological_process def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because it is misleading, since anoikis occurs following detachment of cells from each other and/or from the culture surface; it is not p53 that induces such separation. synonym: "anoikis by p53 class mediator" EXACT [] synonym: "anoikis by signal transduction by p53 class mediator" EXACT [] synonym: "signal transduction by p53 class mediator resulting in induction of anoikis" RELATED [] is_obsolete: true created_by: midori creation_date: 2010-11-03T01:52:56Z [Term] id: GO:0072334 name: UDP-galactose transmembrane transport namespace: biological_process alt_id: GO:0015785 def: "The process in which UDP-galactose is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "UDP-galactose membrane transport" EXACT [] synonym: "UDP-galactose transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport created_by: midori creation_date: 2010-11-03T02:03:36Z [Term] id: GO:0072335 name: regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway is_a: GO:1905292 ! regulation of neural crest cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation relationship: regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation created_by: midori creation_date: 2010-11-03T03:12:38Z [Term] id: GO:0072336 name: negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" RELATED [] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1905293 ! negative regulation of neural crest cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation relationship: negatively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation created_by: midori creation_date: 2010-11-03T03:16:10Z [Term] id: GO:0072337 name: modified amino acid transport namespace: biological_process def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:83821, GOC:mah] synonym: "amino acid derivative transport" EXACT [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport created_by: midori creation_date: 2010-11-04T12:18:23Z [Term] id: GO:0072338 name: cellular lactam metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] synonym: "cellular lactam metabolism" EXACT [GOC:mah] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: midori creation_date: 2010-11-04T04:31:21Z [Term] id: GO:0072339 name: cellular lactam biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] synonym: "cellular lactam anabolism" EXACT [GOC:mah] synonym: "cellular lactam biosynthesis" EXACT [GOC:mah] synonym: "cellular lactam formation" EXACT [GOC:mah] synonym: "cellular lactam synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072338 ! cellular lactam metabolic process created_by: midori creation_date: 2010-11-04T04:33:01Z [Term] id: GO:0072340 name: cellular lactam catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:24995, GOC:mah] synonym: "cellular lactam breakdown" EXACT [GOC:mah] synonym: "cellular lactam catabolism" EXACT [GOC:mah] synonym: "cellular lactam degradation" EXACT [GOC:mah] is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072338 ! cellular lactam metabolic process created_by: midori creation_date: 2010-11-04T04:33:22Z [Term] id: GO:0072341 name: modified amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a modified amino acid." [CHEBI:83821, GOC:mah] synonym: "amino acid derivative binding" EXACT [] is_a: GO:0005488 ! binding created_by: midori creation_date: 2010-11-04T05:45:32Z [Term] id: GO:0072342 name: response to anion stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment." [GOC:cvs, PMID:19641131] is_a: GO:0009651 ! response to salt stress created_by: midori creation_date: 2010-11-05T02:25:28Z [Term] id: GO:0072343 name: pancreatic stellate cell proliferation namespace: biological_process def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706] is_a: GO:0048144 ! fibroblast proliferation created_by: midori creation_date: 2010-11-05T03:04:50Z [Term] id: GO:0072344 name: rescue of stalled ribosome namespace: biological_process def: "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543] is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation created_by: midori creation_date: 2010-11-10T11:54:26Z [Term] id: GO:0072345 name: NAADP-sensitive calcium-release channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428] xref: Reactome:R-HSA-2685505 "TPCN1/2 transport lysosomal Ca2+ to cytosol" is_a: GO:0015278 ! calcium-release channel activity created_by: midori creation_date: 2010-11-10T01:03:35Z [Term] id: GO:0072346 name: cADPR-sensitive calcium-release channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts." [PMID:11752598] is_a: GO:0015278 ! calcium-release channel activity created_by: midori creation_date: 2010-11-10T01:10:51Z [Term] id: GO:0072347 name: response to anesthetic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [CHEBI:38867, GOC:sart] synonym: "response to anaesthetic" EXACT [GOC:mah] is_a: GO:0042493 ! response to drug created_by: midori creation_date: 2010-11-10T01:26:18Z [Term] id: GO:0072348 name: sulfur compound transport namespace: biological_process def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport created_by: midori creation_date: 2010-11-11T11:43:56Z [Term] id: GO:0072349 name: modified amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [CHEBI:83821, GOC:mah] synonym: "amino acid derivative transmembrane transporter activity" EXACT [] synonym: "modified amino acid transporter activity" BROAD [GOC:mah] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0072337 ! modified amino acid transport created_by: midori creation_date: 2010-11-11T11:50:31Z [Term] id: GO:0072350 name: tricarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [CHEBI:27093, GOC:mah] synonym: "tricarboxylic acid metabolism" EXACT [GOC:mah] is_a: GO:0019752 ! carboxylic acid metabolic process created_by: midori creation_date: 2010-11-11T05:07:30Z [Term] id: GO:0072351 name: tricarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah] synonym: "tricarboxylate biosynthesis" EXACT [GOC:mah] synonym: "tricarboxylate biosynthetic process" EXACT [GOC:mah] synonym: "tricarboxylic acid anabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "tricarboxylic acid formation" EXACT [GOC:mah] synonym: "tricarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0072350 ! tricarboxylic acid metabolic process created_by: midori creation_date: 2010-11-11T05:08:54Z [Term] id: GO:0072352 name: tricarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [CHEBI:27093, GOC:mah] synonym: "tricarboxylate catabolic process" EXACT [GOC:mah] synonym: "tricarboxylate catabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid breakdown" EXACT [GOC:mah] synonym: "tricarboxylic acid catabolism" EXACT [GOC:mah] synonym: "tricarboxylic acid degradation" EXACT [GOC:mah] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process created_by: midori creation_date: 2010-11-11T05:11:24Z [Term] id: GO:0072353 name: cellular age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:mah] is_a: GO:0001315 ! age-dependent response to reactive oxygen species is_a: GO:0034614 ! cellular response to reactive oxygen species created_by: midori creation_date: 2010-11-12T11:27:27Z [Term] id: GO:0072354 name: histone kinase activity (H3-T3 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3." [GOC:mah] synonym: "histone threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] synonym: "histone-threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] is_a: GO:0035184 ! histone threonine kinase activity relationship: part_of GO:0072355 ! histone H3-T3 phosphorylation created_by: midori creation_date: 2010-11-12T04:27:57Z [Term] id: GO:0072355 name: histone H3-T3 phosphorylation namespace: biological_process def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone." [GOC:mah] is_a: GO:0035405 ! histone-threonine phosphorylation created_by: midori creation_date: 2010-11-12T04:28:56Z [Term] id: GO:0072356 name: chromosome passenger complex localization to kinetochore namespace: biological_process def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] synonym: "chromosomal passenger complex localization to kinetochore" EXACT [GOC:mah] synonym: "chromosome passenger complex localisation to kinetochore" RELATED [GOC:mah] synonym: "CPC complex localization to kinetochore" EXACT [GOC:vw] synonym: "CPC localization to kinetochore" EXACT [GOC:mah] is_a: GO:0034501 ! protein localization to kinetochore is_a: GO:0034629 ! cellular protein-containing complex localization created_by: midori creation_date: 2010-11-15T11:30:38Z [Term] id: GO:0072357 name: PTW/PP1 phosphatase complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061] is_a: GO:0008287 ! protein serine/threonine phosphatase complex created_by: midori creation_date: 2010-11-15T03:32:27Z [Term] id: GO:0072358 name: cardiovascular system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535] is_a: GO:0048731 ! system development relationship: part_of GO:0072359 ! circulatory system development created_by: midori creation_date: 2010-11-16T11:25:49Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] is_a: GO:0048731 ! system development created_by: midori creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0072360 name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072358 ! cardiovascular system development created_by: midori creation_date: 2010-11-16T11:46:55Z [Term] id: GO:0072361 name: obsolete regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: midori creation_date: 2010-11-16T02:57:18Z [Term] id: GO:0072362 name: obsolete regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] comment: The reason for obsoletion is that this term represented a GO-CAM model. synonym: "regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] is_obsolete: true created_by: midori creation_date: 2010-11-16T02:59:32Z [Term] id: GO:0072363 name: obsolete regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] is_obsolete: true created_by: midori creation_date: 2010-11-16T03:08:25Z [Term] id: GO:0072364 name: regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] synonym: "regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0010565 ! regulation of cellular ketone metabolic process intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: regulates GO:0042180 ! cellular ketone metabolic process created_by: midori creation_date: 2010-11-16T03:11:39Z [Term] id: GO:0072365 name: regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] synonym: "regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: regulates GO:0042180 ! cellular ketone metabolic process created_by: midori creation_date: 2010-11-16T03:12:09Z [Term] id: GO:0072366 name: regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] synonym: "regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0072364 ! regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0042180 ! cellular ketone metabolic process created_by: midori creation_date: 2010-11-16T03:12:47Z [Term] id: GO:0072367 name: regulation of lipid transport by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0032368 ! regulation of lipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006869 ! lipid transport created_by: midori creation_date: 2010-11-16T03:17:54Z [Term] id: GO:0072368 name: regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006869 ! lipid transport created_by: midori creation_date: 2010-11-16T03:18:13Z [Term] id: GO:0072369 name: regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] synonym: "regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0072367 ! regulation of lipid transport by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006869 ! lipid transport created_by: midori creation_date: 2010-11-16T03:23:53Z [Term] id: GO:0072370 name: histone H2A-S121 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone." [GOC:mah, PMID:19965387] synonym: "histone H2A phosphorylation at S121" EXACT [GOC:mah] synonym: "histone H2AS121 phosphorylation" EXACT [GOC:mah] is_a: GO:0035404 ! histone-serine phosphorylation is_a: GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2010-11-16T03:42:52Z [Term] id: GO:0072371 name: histone kinase activity (H2A-S121 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A." [GOC:mah, PMID:19965387] synonym: "histone serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] synonym: "histone-serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] is_a: GO:0035174 ! histone serine kinase activity relationship: part_of GO:0072370 ! histone H2A-S121 phosphorylation created_by: midori creation_date: 2010-11-16T03:42:59Z [Term] id: GO:0072373 name: alpha-carotene epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] xref: EC:1.14.99 is_a: GO:0072374 ! carotene epsilon hydroxylase activity created_by: midori creation_date: 2010-11-19T03:52:25Z [Term] id: GO:0072374 name: carotene epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] xref: EC:1.14.99 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: midori creation_date: 2010-11-19T03:57:55Z [Term] id: GO:0072375 name: medium-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375] synonym: "middle-term memory" EXACT [GOC:sart] synonym: "MTM" NARROW [GOC:sart] is_a: GO:0007613 ! memory created_by: midori creation_date: 2010-11-22T11:26:54Z [Term] id: GO:0072376 name: protein activation cascade namespace: biological_process def: "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde] synonym: "protein activation pathway" EXACT [GOC:add] synonym: "protein activitory cascade" EXACT [GOC:add] is_a: GO:0019538 ! protein metabolic process is_a: GO:0050896 ! response to stimulus created_by: midori creation_date: 2010-11-22T02:54:18Z [Term] id: GO:0072377 name: blood coagulation, common pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." [GOC:add, GOC:mah, GOC:pde, PMID:1931959] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation created_by: midori creation_date: 2010-11-22T03:01:12Z [Term] id: GO:0072378 name: blood coagulation, fibrin clot formation namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0007596 ! blood coagulation created_by: midori creation_date: 2010-11-22T03:09:32Z [Term] id: GO:0072379 name: ER membrane insertion complex namespace: cellular_component def: "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast." [GOC:mah, PMID:20676083, PMID:20850366] synonym: "endoplasmic reticulum membrane insertion complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: midori creation_date: 2010-11-24T02:07:09Z [Term] id: GO:0072380 name: TRC complex namespace: cellular_component def: "An ER membrane insertion complex that contains subunits that recognize two types of transmembrane domain signals. In budding yeast the complex contains Get4p, Get5p, Sgt2p, and at least two heat shock proteins (HSPs)." [GOC:mah, PMID:20850366] synonym: "TMD recognition complex" EXACT [PMID:20850366] is_a: GO:0072379 ! ER membrane insertion complex created_by: midori creation_date: 2010-11-24T02:43:41Z [Term] id: GO:0072381 name: positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway is_a: GO:1905294 ! positive regulation of neural crest cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation relationship: positively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation created_by: midori creation_date: 2010-11-24T03:10:15Z [Term] id: GO:0072382 name: minus-end-directed vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule minus-end-directed vesicle distribution" NARROW [GOC:rl] synonym: "microtubule minus-end-directed vesicle localization" EXACT [GOC:rl] is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0072385 ! minus-end-directed organelle transport along microtubule created_by: midori creation_date: 2010-12-01T04:12:59Z [Term] id: GO:0072383 name: plus-end-directed vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule plus-end-directed vesicle distribution" NARROW [GOC:rl] synonym: "microtubule plus-end-directed vesicle localization" EXACT [GOC:rl] is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0072386 ! plus-end-directed organelle transport along microtubule created_by: midori creation_date: 2010-12-01T04:24:51Z [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! transport along microtubule is_a: GO:0051656 ! establishment of organelle localization created_by: midori creation_date: 2010-12-01T04:59:11Z [Term] id: GO:0072385 name: minus-end-directed organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule minus-end-directed organelle distribution" NARROW [GOC:rl] synonym: "microtubule minus-end-directed organelle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule created_by: midori creation_date: 2010-12-01T05:01:20Z [Term] id: GO:0072386 name: plus-end-directed organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] synonym: "microtubule plus-end-directed organelle distribution" NARROW [GOC:rl] synonym: "microtubule plus-end-directed organelle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule created_by: midori creation_date: 2010-12-01T05:02:09Z [Term] id: GO:0072387 name: flavin adenine dinucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 metabolic process" EXACT [] synonym: "flavin adenine dinucleotide metabolism" EXACT [] synonym: "flavin-adenine dinucleotide metabolic process" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process created_by: midori creation_date: 2010-12-02T04:21:43Z [Term] id: GO:0072388 name: flavin adenine dinucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 biosynthetic process" EXACT [] synonym: "flavin adenine dinucleotide anabolism" EXACT [] synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] synonym: "flavin adenine dinucleotide formation" EXACT [] synonym: "flavin adenine dinucleotide synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process created_by: midori creation_date: 2010-12-02T04:26:34Z [Term] id: GO:0072389 name: flavin adenine dinucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [CHEBI:24040, GOC:mah] synonym: "FAD or FADH2 catabolic process" EXACT [] synonym: "flavin adenine dinucleotide breakdown" EXACT [] synonym: "flavin adenine dinucleotide catabolism" EXACT [] synonym: "flavin adenine dinucleotide degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process created_by: midori creation_date: 2010-12-02T04:28:02Z [Term] id: GO:0072390 name: phenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process created_by: midori creation_date: 2010-12-06T04:05:51Z [Term] id: GO:0072391 name: phenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072390 ! phenol metabolic process created_by: midori creation_date: 2010-12-06T04:08:04Z [Term] id: GO:0072392 name: phenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [CHEBI:15882, GOC:mah] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072390 ! phenol metabolic process created_by: midori creation_date: 2010-12-06T04:08:44Z [Term] id: GO:0072393 name: microtubule anchoring at microtubule organizing center namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah] synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF] is_a: GO:0034453 ! microtubule anchoring created_by: midori creation_date: 2010-12-07T11:54:35Z [Term] id: GO:0072394 name: detection of stimulus involved in cell cycle checkpoint namespace: biological_process alt_id: GO:0072403 alt_id: GO:0072406 def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint." [GOC:mtg_cell_cycle] synonym: "cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "detection of stimulus involved in G1/S transition checkpoint" RELATED [] synonym: "detection of stimulus involved in G2/M transition checkpoint" RELATED [] synonym: "G1/S transition checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G1/S transition checkpoint sensor process" RELATED [GOC:mah] synonym: "G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in cell cycle checkpoint" RELATED [GOC:mah] synonym: "sensing involved in G1/S transition checkpoint" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0090429 ! detection of endogenous biotic stimulus intersection_of: GO:0090429 ! detection of endogenous biotic stimulus intersection_of: part_of GO:0000075 ! cell cycle checkpoint relationship: part_of GO:0000075 ! cell cycle checkpoint created_by: midori creation_date: 2010-12-08T02:55:56Z [Term] id: GO:0072395 name: signal transduction involved in cell cycle checkpoint namespace: biological_process alt_id: GO:0072404 alt_id: GO:0072407 def: "A signal transduction process that contributes to a cell cycle checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in G2/M transition checkpoint" EXACT [] is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0000075 ! cell cycle checkpoint relationship: part_of GO:0000075 ! cell cycle checkpoint created_by: midori creation_date: 2010-12-08T02:59:45Z [Term] id: GO:0072396 name: response to cell cycle checkpoint signaling namespace: biological_process alt_id: GO:0072405 alt_id: GO:0072408 def: "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "G1/S transition checkpoint effector process" RELATED [GOC:mah] synonym: "G2/M transition checkpoint effector process" RELATED [GOC:mah] synonym: "response to G1/S transition checkpoint signaling" RELATED [] synonym: "response to G2/M transition checkpoint signaling" RELATED [] synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah] synonym: "response to signal involved in G1/S transition checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus created_by: midori creation_date: 2010-12-08T03:05:46Z [Term] id: GO:0072397 name: detection of stimulus involved in cytokinesis checkpoint namespace: biological_process alt_id: GO:0072418 def: "The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint." [GOC:mtg_cell_cycle] synonym: "cytokinesis checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cytokinesis checkpoint sensor process" RELATED [GOC:mah] synonym: "detection of stimulus involved in septin checkpoint" RELATED [] synonym: "sensing involved in cytokinesis checkpoint" RELATED [GOC:mah] synonym: "sensing involved in septin checkpoint" RELATED [GOC:mah] synonym: "septin checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "septin checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:18:11Z [Term] id: GO:0072398 name: signal transduction involved in cytokinesis checkpoint namespace: biological_process alt_id: GO:0072419 def: "A signal transduction process that contributes to a cytokinesis checkpoint." [GOC:mtg_cell_cycle] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:22:21Z [Term] id: GO:0072399 name: response to cytokinesis checkpoint signaling namespace: biological_process alt_id: GO:0072420 def: "A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "cytokinesis checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in cytokinesis checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-08T03:23:32Z [Term] id: GO:0072400 name: detection of stimulus involved in mitotic DNA integrity checkpoint namespace: biological_process alt_id: GO:0072457 def: "The series of events in which information about DNA integrity is received and converted into a molecular signal, contributing to a mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in mitotic G2/M transition decatenation checkpoint" RELATED [] synonym: "DNA integrity checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA integrity checkpoint sensor process" RELATED [GOC:mah] synonym: "mitotic G2/M transition decatenation checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic G2/M transition decatenation checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA integrity checkpoint" RELATED [GOC:mah] synonym: "sensing involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044774 ! mitotic DNA integrity checkpoint relationship: part_of GO:0044774 ! mitotic DNA integrity checkpoint created_by: midori creation_date: 2010-12-08T03:29:11Z [Term] id: GO:0072401 name: signal transduction involved in DNA integrity checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA integrity checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031570 ! DNA integrity checkpoint relationship: part_of GO:0031570 ! DNA integrity checkpoint created_by: midori creation_date: 2010-12-08T03:31:56Z [Term] id: GO:0072402 name: response to DNA integrity checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-08T03:32:17Z [Term] id: GO:0072409 name: detection of stimulus involved in meiotic cell cycle checkpoint namespace: biological_process def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint." [GOC:mah, GOC:mtg_cell_cycle] synonym: "meiotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic cell cycle checkpoint" RELATED [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint intersection_of: GO:0090429 ! detection of endogenous biotic stimulus intersection_of: part_of GO:0033313 ! meiotic cell cycle checkpoint relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:47:50Z [Term] id: GO:0072410 name: response to meiotic cell cycle checkpoint signaling namespace: biological_process def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint." [GOC:mah] synonym: "meiotic cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic cell cycle checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-08T03:48:38Z [Term] id: GO:0072411 name: signal transduction involved in meiotic cell cycle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic cell cycle checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0033313 ! meiotic cell cycle checkpoint relationship: part_of GO:0033313 ! meiotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:48:45Z [Term] id: GO:0072412 name: detection of stimulus involved in mitotic cell cycle checkpoint namespace: biological_process alt_id: GO:0072454 alt_id: GO:0072472 def: "The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in mitotic cell cycle G1/S checkpoint" RELATED [] synonym: "mitotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle checkpoint sensor process" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007093 ! mitotic cell cycle checkpoint relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:48:57Z [Term] id: GO:0072413 name: signal transduction involved in mitotic cell cycle checkpoint namespace: biological_process alt_id: GO:0072456 alt_id: GO:0072474 def: "A signal transduction process that contributes to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in mitotic cell cycle G1/S checkpoint" RELATED [] synonym: "signal transduction involved in mitotic G2/M transition checkpoint" RELATED [] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0007093 ! mitotic cell cycle checkpoint relationship: part_of GO:0007093 ! mitotic cell cycle checkpoint created_by: midori creation_date: 2010-12-08T03:50:28Z [Term] id: GO:0072414 name: response to mitotic cell cycle checkpoint signaling namespace: biological_process alt_id: GO:0072455 alt_id: GO:0072473 def: "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint effector process" RELATED [GOC:mah] synonym: "mitotic G2/M transition checkpoint effector process" RELATED [GOC:mah] synonym: "response to mitotic cell cycle G1/S checkpoint signaling" RELATED [] synonym: "response to mitotic G2/M transition checkpoint signal" RELATED [] synonym: "response to signal involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-08T03:50:43Z [Term] id: GO:0072415 name: detection of stimulus involved in spindle checkpoint namespace: biological_process def: "The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint." [GOC:mah, GOC:mtg_cell_cycle] synonym: "sensing involved in spindle checkpoint" RELATED [GOC:mah] synonym: "spindle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "spindle checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072394 ! detection of stimulus involved in cell cycle checkpoint intersection_of: GO:0090429 ! detection of endogenous biotic stimulus intersection_of: part_of GO:0031577 ! spindle checkpoint relationship: part_of GO:0031577 ! spindle checkpoint created_by: midori creation_date: 2010-12-08T03:54:50Z [Term] id: GO:0072416 name: signal transduction involved in spindle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a spindle checkpoint." [GOC:mah] is_a: GO:0072395 ! signal transduction involved in cell cycle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031577 ! spindle checkpoint relationship: part_of GO:0031577 ! spindle checkpoint created_by: midori creation_date: 2010-12-08T03:55:51Z [Term] id: GO:0072417 name: response to spindle checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of spindle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah] synonym: "spindle checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-08T03:56:04Z [Term] id: GO:0072421 name: detection of DNA damage stimulus involved in DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: part_of GO:0000077 ! DNA damage checkpoint relationship: part_of GO:0000077 ! DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:16:04Z [Term] id: GO:0072422 name: signal transduction involved in DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] is_a: GO:0042770 ! signal transduction in response to DNA damage is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0000077 ! DNA damage checkpoint relationship: part_of GO:0000077 ! DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:18:11Z [Term] id: GO:0072423 name: response to DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072402 ! response to DNA integrity checkpoint signaling created_by: midori creation_date: 2010-12-08T04:20:25Z [Term] id: GO:0072424 name: detection of DNA damage stimulus involved in G2 DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint" EXACT [] synonym: "G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: part_of GO:0031572 ! G2 DNA damage checkpoint relationship: part_of GO:0031572 ! G2 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:24:59Z [Term] id: GO:0072425 name: signal transduction involved in G2 DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031572 ! G2 DNA damage checkpoint relationship: part_of GO:0031572 ! G2 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:25:26Z [Term] id: GO:0072426 name: response to G2 DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072423 ! response to DNA damage checkpoint signaling created_by: midori creation_date: 2010-12-08T04:26:35Z [Term] id: GO:0072427 name: detection of DNA damage stimulus involved in intra-S DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint." [GOC:mah] synonym: "intra-S DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "intra-S DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in intra-S DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: part_of GO:0031573 ! intra-S DNA damage checkpoint relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:30:27Z [Term] id: GO:0072428 name: signal transduction involved in intra-S DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to an intra-S DNA damage checkpoint." [GOC:mah] is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031573 ! intra-S DNA damage checkpoint relationship: part_of GO:0031573 ! intra-S DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:31:08Z [Term] id: GO:0072429 name: response to intra-S DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072423 ! response to DNA damage checkpoint signaling created_by: midori creation_date: 2010-12-08T04:31:56Z [Term] id: GO:0072430 name: detection of DNA damage stimulus involved in mitotic G1 DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072421 ! detection of DNA damage stimulus involved in DNA damage checkpoint is_a: GO:1902399 ! detection of stimulus involved in G1 DNA damage checkpoint is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint relationship: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:37:40Z [Term] id: GO:0072431 name: signal transduction involved in mitotic G1 DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] is_a: GO:1902400 ! intracellular signal transduction involved in G1 DNA damage checkpoint is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint relationship: part_of GO:0031571 ! mitotic G1 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:37:55Z [Term] id: GO:0072432 name: response to G1 DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072423 ! response to DNA damage checkpoint signaling created_by: midori creation_date: 2010-12-08T04:38:04Z [Term] id: GO:0072433 name: detection of DNA damage stimulus involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint" EXACT [] synonym: "mitotic G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic G2/M transition DNA damage checkpoint" RELATED [GOC:mah] is_a: GO:0072424 ! detection of DNA damage stimulus involved in G2 DNA damage checkpoint is_a: GO:1902401 ! detection of stimulus involved in mitotic DNA damage checkpoint is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint relationship: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:43:14Z [Term] id: GO:0072434 name: signal transduction involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle is_a: GO:0072425 ! signal transduction involved in G2 DNA damage checkpoint is_a: GO:1902402 ! signal transduction involved in mitotic DNA damage checkpoint intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint relationship: part_of GO:0007095 ! mitotic G2 DNA damage checkpoint created_by: midori creation_date: 2010-12-08T04:43:48Z [Term] id: GO:0072435 name: response to mitotic G2 DNA damage checkpoint signaling namespace: biological_process alt_id: GO:0072458 def: "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic G2/M transition decatenation checkpoint effector process" RELATED [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic G2/M transition decatenation checkpoint signaling" RELATED [] synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072426 ! response to G2 DNA damage checkpoint signaling created_by: midori creation_date: 2010-12-08T04:44:01Z [Term] id: GO:0072436 name: detection of stimulus involved in DNA replication checkpoint namespace: biological_process def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint." [GOC:mtg_cell_cycle] synonym: "DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in DNA replication checkpoint" RELATED [GOC:mah] is_a: GO:0042769 ! DNA damage response, detection of DNA damage intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0000076 ! DNA replication checkpoint relationship: part_of GO:0000076 ! DNA replication checkpoint created_by: midori creation_date: 2010-12-08T04:52:09Z [Term] id: GO:0072437 name: signal transduction involved in DNA replication checkpoint namespace: biological_process def: "A signal transduction process that contributes to a DNA replication checkpoint." [GOC:mah] is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0000076 ! DNA replication checkpoint relationship: part_of GO:0000076 ! DNA replication checkpoint created_by: midori creation_date: 2010-12-08T04:52:31Z [Term] id: GO:0072438 name: response to DNA replication checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA replication checkpoint" EXACT [GOC:mah] is_a: GO:0072402 ! response to DNA integrity checkpoint signaling created_by: midori creation_date: 2010-12-08T04:53:12Z [Term] id: GO:0072439 name: detection of stimulus involved in meiotic DNA replication checkpoint namespace: biological_process def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint." [GOC:mtg_cell_cycle] synonym: "meiotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic DNA replication checkpoint" RELATED [GOC:mah] is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0033315 ! meiotic G2/MI DNA replication checkpoint relationship: part_of GO:0033315 ! meiotic G2/MI DNA replication checkpoint created_by: midori creation_date: 2010-12-08T04:59:08Z [Term] id: GO:0072440 name: signal transduction involved in meiotic DNA replication checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic DNA replication checkpoint." [GOC:mah] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0033315 ! meiotic G2/MI DNA replication checkpoint relationship: part_of GO:0033315 ! meiotic G2/MI DNA replication checkpoint created_by: midori creation_date: 2010-12-08T04:59:18Z [Term] id: GO:0072441 name: response to meiotic DNA replication checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "meiotic DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic DNA replication checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling is_a: GO:0072438 ! response to DNA replication checkpoint signaling created_by: midori creation_date: 2010-12-08T04:59:26Z [Term] id: GO:0072442 name: detection of stimulus involved in mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0072445 def: "The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in S-M checkpoint" RELATED [] synonym: "mitotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic DNA replication checkpoint sensor process" RELATED [GOC:mah] synonym: "S-M checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "S-M checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic DNA replication checkpoint" RELATED [GOC:mah] synonym: "sensing involved in S-M checkpoint" RELATED [GOC:mah] is_a: GO:0072400 ! detection of stimulus involved in mitotic DNA integrity checkpoint is_a: GO:0072436 ! detection of stimulus involved in DNA replication checkpoint is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0033314 ! mitotic DNA replication checkpoint relationship: part_of GO:0033314 ! mitotic DNA replication checkpoint created_by: midori creation_date: 2010-12-08T05:12:49Z [Term] id: GO:0072443 name: signal transduction involved in mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0072446 alt_id: GO:0072459 def: "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in mitotic G2/M transition decatenation checkpoint" RELATED [] synonym: "signal transduction involved in S-M checkpoint" EXACT [] is_a: GO:0072437 ! signal transduction involved in DNA replication checkpoint is_a: GO:1902403 ! signal transduction involved in mitotic DNA integrity checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0033314 ! mitotic DNA replication checkpoint relationship: part_of GO:0033314 ! mitotic DNA replication checkpoint created_by: midori creation_date: 2010-12-08T05:12:56Z [Term] id: GO:0072444 name: response to mitotic DNA replication checkpoint signaling namespace: biological_process alt_id: GO:0072447 def: "A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic DNA replication checkpoint effector process" EXACT [GOC:mah] synonym: "response to S-M checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic DNA replication checkpoint" EXACT [GOC:mah] synonym: "response to signal involved in S-M checkpoint" EXACT [GOC:mah] synonym: "S-M checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072438 ! response to DNA replication checkpoint signaling created_by: midori creation_date: 2010-12-08T05:13:27Z [Term] id: GO:0072448 name: detection of stimulus involved in G1 cell size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [] synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [GOC:mah] is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0031568 ! G1 cell size control checkpoint relationship: part_of GO:0031568 ! G1 cell size control checkpoint created_by: midori creation_date: 2010-12-09T10:56:32Z [Term] id: GO:0072449 name: response to G1 cell size control checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072470 ! response to cell size control checkpoint signaling created_by: midori creation_date: 2010-12-09T10:56:39Z [Term] id: GO:0072450 name: signal transduction involved in G1 cell size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of mitosis." [GOC:mah] synonym: "signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [] is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031568 ! G1 cell size control checkpoint relationship: part_of GO:0031568 ! G1 cell size control checkpoint created_by: midori creation_date: 2010-12-09T10:56:44Z [Term] id: GO:0072451 name: detection of stimulus involved in G2 cell size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in G2/M transition size control checkpoint" EXACT [] synonym: "detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah] synonym: "G2/M transition size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "G2/M transition size control checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in G2/M transition size control checkpoint" RELATED [GOC:mah] is_a: GO:0072469 ! detection of stimulus involved in cell size control checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0031569 ! mitotic G2 cell size control checkpoint relationship: part_of GO:0031569 ! mitotic G2 cell size control checkpoint created_by: midori creation_date: 2010-12-09T11:14:00Z [Term] id: GO:0072452 name: response to G2 transition size control checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "G2/M transition size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to G2/M transition size control checkpoint signaling" EXACT [] synonym: "response to mitotic cell cycle G2/M transition size control checkpoint signaling" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072470 ! response to cell size control checkpoint signaling created_by: midori creation_date: 2010-12-09T11:14:12Z [Term] id: GO:0072453 name: signal transduction involved in G2 cell size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell size control checkpoint during the G2/M transition of mitosis." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in G2/M transition size control checkpoint" EXACT [] synonym: "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0072471 ! signal transduction involved in cell size control checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031569 ! mitotic G2 cell size control checkpoint relationship: part_of GO:0031569 ! mitotic G2 cell size control checkpoint created_by: midori creation_date: 2010-12-09T11:14:22Z [Term] id: GO:0072460 name: detection of stimulus involved in meiotic recombination checkpoint namespace: biological_process def: "The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint." [GOC:mah] synonym: "meiotic recombination checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic recombination checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic recombination checkpoint" RELATED [GOC:mah] is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint intersection_of: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint intersection_of: part_of GO:0051598 ! meiotic recombination checkpoint relationship: part_of GO:0051598 ! meiotic recombination checkpoint created_by: midori creation_date: 2010-12-09T11:36:42Z [Term] id: GO:0072461 name: response to meiotic recombination checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "meiotic recombination checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic recombination checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0051598 ! meiotic recombination checkpoint created_by: midori creation_date: 2010-12-09T11:37:01Z [Term] id: GO:0072462 name: signal transduction involved in meiotic recombination checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic recombination checkpoint." [GOC:mah] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0051598 ! meiotic recombination checkpoint relationship: part_of GO:0051598 ! meiotic recombination checkpoint created_by: midori creation_date: 2010-12-09T11:37:17Z [Term] id: GO:0072463 name: detection of stimulus involved in meiotic spindle assembly checkpoint namespace: biological_process def: "The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint." [GOC:mah] synonym: "meiotic spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "meiotic spindle assembly checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in meiotic spindle assembly checkpoint" RELATED [GOC:mah] is_a: GO:0072409 ! detection of stimulus involved in meiotic cell cycle checkpoint is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint is_a: GO:1902397 ! detection of stimulus involved in meiotic spindle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0033316 ! meiotic spindle assembly checkpoint relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T11:37:41Z [Term] id: GO:0072464 name: response to meiotic spindle assembly checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "meiotic spindle assembly checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in meiotic spindle assembly checkpoint" EXACT [GOC:mah] is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling is_a: GO:0072485 ! response to spindle assembly checkpoint signaling created_by: midori creation_date: 2010-12-09T11:37:48Z [Term] id: GO:0072465 name: signal transduction involved in meiotic spindle assembly checkpoint namespace: biological_process def: "A signal transduction process that contributes to a meiotic spindle assembly checkpoint." [GOC:mtg_cell_cycle] is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint is_a: GO:1902398 ! intracellular signal transduction involved in meiotic spindle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0033316 ! meiotic spindle assembly checkpoint relationship: part_of GO:0033316 ! meiotic spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T11:37:54Z [Term] id: GO:0072466 name: obsolete detection of stimulus involved in cell shape checkpoint namespace: biological_process def: "OBSOLETE. The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint." [GOC:mah, GOC:mtg_cell_cycle] comment: This term was made obsolete because it was ambiguous. synonym: "cell shape checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell shape checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in cell shape checkpoint" RELATED [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-12-09T11:43:58Z [Term] id: GO:0072467 name: obsolete response to cell shape checkpoint signaling namespace: biological_process def: "OBSOLETE. A process that occurs in response to signals generated as a result of cell shape checkpoint signaling." [GOC:mtg_cell_cycle] comment: This term was made obsolete because it was ambiguous. synonym: "cell shape checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in cell shape checkpoint" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2010-12-09T11:44:11Z [Term] id: GO:0072468 name: obsolete signal transduction involved in cell shape checkpoint namespace: biological_process def: "OBSOLETE. A signal transduction process that contributes to a cell shape checkpoint." [GOC:mah] comment: This term was made obsolete because it was ambiguous. is_obsolete: true created_by: midori creation_date: 2010-12-09T11:45:12Z [Term] id: GO:0072469 name: detection of stimulus involved in cell size control checkpoint namespace: biological_process def: "The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint." [GOC:mtg_cell_cycle] synonym: "cell size control checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "cell size control checkpoint sensor process" RELATED [GOC:mah] synonym: "detection of stimulus involved in mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] synonym: "sensing involved in cell size control checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0031567 ! mitotic cell size control checkpoint relationship: part_of GO:0031567 ! mitotic cell size control checkpoint created_by: midori creation_date: 2010-12-09T11:46:08Z [Term] id: GO:0072470 name: response to cell size control checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of cell size control checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "cell size control checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle cell size control checkpoint signaling" EXACT [GOC:mah] synonym: "response to signal involved in cell size control checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling created_by: midori creation_date: 2010-12-09T11:46:13Z [Term] id: GO:0072471 name: signal transduction involved in cell size control checkpoint namespace: biological_process def: "A signal transduction process that contributes to a cell size control checkpoint during mitosis." [GOC:mtg_cell_cycle] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031567 ! mitotic cell size control checkpoint relationship: part_of GO:0031567 ! mitotic cell size control checkpoint created_by: midori creation_date: 2010-12-09T11:46:18Z [Term] id: GO:0072475 name: detection of stimulus involved in mitotic spindle checkpoint namespace: biological_process def: "The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in mitotic cell cycle spindle checkpoint" EXACT [] synonym: "mitotic cell cycle spindle checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle spindle checkpoint" RELATED [GOC:mah] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0071174 ! mitotic spindle checkpoint relationship: part_of GO:0071174 ! mitotic spindle checkpoint created_by: midori creation_date: 2010-12-09T11:49:55Z [Term] id: GO:0072476 name: response to mitotic spindle checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle spindle checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072417 ! response to spindle checkpoint signaling created_by: midori creation_date: 2010-12-09T11:50:09Z [Term] id: GO:0072477 name: signal transduction involved in mitotic spindle checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in mitotic cell cycle spindle checkpoint" EXACT [] is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint is_a: GO:0072416 ! signal transduction involved in spindle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0071174 ! mitotic spindle checkpoint relationship: part_of GO:0071174 ! mitotic spindle checkpoint created_by: midori creation_date: 2010-12-09T11:50:16Z [Term] id: GO:0072478 name: detection of stimulus involved in mitotic spindle assembly checkpoint namespace: biological_process alt_id: GO:1902419 def: "The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in Dma1-dependent checkpoint" NARROW [] synonym: "detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint" EXACT [] synonym: "detection of stimulus involved in SAC-independent checkpoint" EXACT [GOC:TermGenie] synonym: "mitotic cell cycle spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle assembly checkpoint sensor process" RELATED [GOC:mah] synonym: "perception of stimulus involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "perception of stimulus involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] synonym: "sensing involved in mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:mah] synonym: "stimulus detection involved in DMA1-dependent checkpoint" NARROW [GOC:TermGenie] synonym: "stimulus detection involved in SAC-independent checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus sensing involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072475 ! detection of stimulus involved in mitotic spindle checkpoint is_a: GO:0072484 ! detection of stimulus involved in spindle assembly checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0007094 ! mitotic spindle assembly checkpoint relationship: part_of GO:0007094 ! mitotic spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T12:11:18Z [Term] id: GO:0072479 name: response to mitotic cell cycle spindle assembly checkpoint signaling namespace: biological_process alt_id: GO:0044811 def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle spindle assembly checkpoint effector process" EXACT [GOC:mah] synonym: "response to Dma1-dependent checkpoint signaling" NARROW [] synonym: "response to Dma1-dependent checkpoint signalling" NARROW [] synonym: "response to signal involved in mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:mah] is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling is_a: GO:0072485 ! response to spindle assembly checkpoint signaling created_by: midori creation_date: 2010-12-09T12:11:31Z [Term] id: GO:0072480 name: signal transduction involved in mitotic spindle assembly checkpoint namespace: biological_process alt_id: GO:1902420 def: "A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle] synonym: "signal transduction involved in Dma1-dependent checkpoint" NARROW [] synonym: "signal transduction involved in mitotic cell cycle spindle assembly checkpoint" EXACT [] synonym: "signal transduction involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] synonym: "signaling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie] synonym: "signaling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "signaling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie] synonym: "signalling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "signalling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072477 ! signal transduction involved in mitotic spindle checkpoint is_a: GO:0072486 ! signal transduction involved in spindle assembly checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0007094 ! mitotic spindle assembly checkpoint relationship: part_of GO:0007094 ! mitotic spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T12:11:42Z [Term] id: GO:0072481 name: detection of stimulus involved in mitotic spindle orientation checkpoint namespace: biological_process def: "The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle] synonym: "detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint" EXACT [] synonym: "mitotic cell cycle spindle orientation checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "mitotic cell cycle spindle orientation checkpoint sensor process" RELATED [GOC:mah] synonym: "sensing involved in mitotic cell cycle spindle orientation checkpoint" RELATED [GOC:mah] is_a: GO:0072475 ! detection of stimulus involved in mitotic spindle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0031578 ! mitotic spindle orientation checkpoint relationship: part_of GO:0031578 ! mitotic spindle orientation checkpoint created_by: midori creation_date: 2010-12-09T12:11:52Z [Term] id: GO:0072482 name: response to mitotic cell cycle spindle orientation checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle spindle orientation checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in mitotic cell cycle spindle orientation checkpoint" EXACT [GOC:mah] is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling created_by: midori creation_date: 2010-12-09T12:11:56Z [Term] id: GO:0072483 name: signal transduction involved in mitotic cell cycle spindle orientation checkpoint namespace: biological_process def: "A signal transduction process that contributes to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle] is_a: GO:0072477 ! signal transduction involved in mitotic spindle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0031578 ! mitotic spindle orientation checkpoint relationship: part_of GO:0031578 ! mitotic spindle orientation checkpoint created_by: midori creation_date: 2010-12-09T12:12:00Z [Term] id: GO:0072484 name: detection of stimulus involved in spindle assembly checkpoint namespace: biological_process def: "The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint." [GOC:mah] synonym: "sensing involved in spindle assembly checkpoint" RELATED [GOC:mah] synonym: "spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] synonym: "spindle assembly checkpoint sensor process" RELATED [GOC:mah] is_a: GO:0072415 ! detection of stimulus involved in spindle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0071173 ! spindle assembly checkpoint relationship: part_of GO:0071173 ! spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T12:19:16Z [Term] id: GO:0072485 name: response to spindle assembly checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "response to signal involved in spindle assembly checkpoint" EXACT [GOC:mah] synonym: "spindle assembly checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072417 ! response to spindle checkpoint signaling created_by: midori creation_date: 2010-12-09T12:19:35Z [Term] id: GO:0072486 name: signal transduction involved in spindle assembly checkpoint namespace: biological_process def: "A signal transduction process that contributes to a spindle assembly checkpoint." [GOC:mtg_cell_cycle] is_a: GO:0072416 ! signal transduction involved in spindle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0071173 ! spindle assembly checkpoint relationship: part_of GO:0071173 ! spindle assembly checkpoint created_by: midori creation_date: 2010-12-09T12:19:51Z [Term] id: GO:0072487 name: MSL complex namespace: cellular_component def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852] is_a: GO:1902562 ! H4 histone acetyltransferase complex created_by: midori creation_date: 2010-12-10T10:15:11Z [Term] id: GO:0072488 name: ammonium transmembrane transport namespace: biological_process def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ammonium membrane transport" EXACT [] is_a: GO:0015696 ! ammonium transport is_a: GO:0098655 ! cation transmembrane transport created_by: midori creation_date: 2010-12-10T10:29:57Z [Term] id: GO:0072489 name: methylammonium transmembrane transport namespace: biological_process def: "The process in which methylammonium is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "methylammonium membrane transport" EXACT [] is_a: GO:0015843 ! methylammonium transport is_a: GO:0072488 ! ammonium transmembrane transport created_by: midori creation_date: 2010-12-10T10:36:33Z [Term] id: GO:0072490 name: toluene-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah] synonym: "toluene and derivative metabolic process" EXACT [GOC:mah] synonym: "toluene-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: midori creation_date: 2010-12-14T03:46:52Z [Term] id: GO:0072491 name: toluene-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives." [CHEBI:27024, GOC:mah] synonym: "toluene and derivative catabolic process" EXACT [GOC:mah] synonym: "toluene-containing compound breakdown" EXACT [GOC:mah] synonym: "toluene-containing compound catabolism" EXACT [GOC:mah] synonym: "toluene-containing compound degradation" EXACT [GOC:mah] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: midori creation_date: 2010-12-14T03:51:03Z [Term] id: GO:0072492 name: host cell mitochondrial intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope." [GOC:ecd] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044190 ! host cell mitochondrial envelope created_by: midori creation_date: 2010-12-15T11:44:02Z [Term] id: GO:0072493 name: host cell endosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of the host cell endosome." [GOC:ecd] synonym: "host endosome lumen" EXACT [GOC:mah] is_a: GO:0033655 ! host cell cytoplasm part relationship: part_of GO:0044174 ! host cell endosome created_by: midori creation_date: 2010-12-15T11:45:53Z [Term] id: GO:0072494 name: host multivesicular body namespace: cellular_component def: "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm." [GOC:rph] synonym: "host cell multivesicular body" EXACT [GOC:mah] is_a: GO:0044184 ! host cell late endosome created_by: midori creation_date: 2010-12-15T11:48:39Z [Term] id: GO:0072495 name: host cell Cajal body namespace: cellular_component def: "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:rph] synonym: "coiled body of host" EXACT [GOC:rph] synonym: "host cell coiled body" EXACT [GOC:mah] is_a: GO:0044094 ! host cell nuclear part relationship: part_of GO:0044095 ! host cell nucleoplasm created_by: midori creation_date: 2010-12-15T11:51:12Z [Term] id: GO:0072496 name: Pup transferase activity namespace: molecular_function def: "Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages." [GOC:sp] synonym: "Pup conjugating enzyme activity" NARROW [GOC:mah] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: midori creation_date: 2010-12-15T11:58:13Z [Term] id: GO:0072497 name: mesenchymal stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF] is_a: GO:0048863 ! stem cell differentiation created_by: midori creation_date: 2010-12-15T12:59:30Z [Term] id: GO:0072498 name: embryonic skeletal joint development namespace: biological_process def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure." [GOC:BHF, GOC:vk] is_a: GO:0048706 ! embryonic skeletal system development created_by: midori creation_date: 2010-12-15T04:14:42Z [Term] id: GO:0072499 name: photoreceptor cell axon guidance namespace: biological_process def: "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] synonym: "photoreceptor cell axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance created_by: midori creation_date: 2010-12-15T05:34:10Z [Term] id: GO:0072500 name: obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah] comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand. synonym: "negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] is_obsolete: true consider: GO:0000122 consider: GO:0004879 consider: GO:0030374 consider: GO:0030522 created_by: midori creation_date: 2010-12-16T11:47:39Z [Term] id: GO:0072501 name: cellular divalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular trivalent inorganic anion homeostasis' ; GO:0072502'). is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0072505 ! divalent inorganic anion homeostasis created_by: midori creation_date: 2010-12-16T12:53:05Z [Term] id: GO:0072502 name: cellular trivalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular divalent inorganic anion homeostasis' ; GO:0072501'). is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0072506 ! trivalent inorganic anion homeostasis created_by: midori creation_date: 2010-12-16T12:53:42Z [Term] id: GO:0072503 name: cellular divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504'). is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: midori creation_date: 2010-12-16T01:25:40Z [Term] id: GO:0072504 name: cellular trivalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell." [GOC:mah] comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular divalent inorganic cation homeostasis' ; GO:0072503'). is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0072508 ! trivalent inorganic cation homeostasis created_by: midori creation_date: 2010-12-16T01:26:43Z [Term] id: GO:0072505 name: divalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506'). is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T01:39:00Z [Term] id: GO:0072506 name: trivalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505'). is_a: GO:0055081 ! anion homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T01:39:39Z [Term] id: GO:0072507 name: divalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T03:22:48Z [Term] id: GO:0072508 name: trivalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell." [GOC:mah] comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'divalent inorganic cation homeostasis' ; GO:0072507'). is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis created_by: midori creation_date: 2010-12-16T03:26:40Z [Term] id: GO:0072509 name: divalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic cations with a valency of two from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0072511 ! divalent inorganic cation transport created_by: midori creation_date: 2010-12-16T04:01:36Z [Term] id: GO:0072510 name: trivalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic cations with a valency of three from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:mah] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0072512 ! trivalent inorganic cation transport created_by: midori creation_date: 2010-12-16T04:03:00Z [Term] id: GO:0072511 name: divalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] is_a: GO:0006812 ! cation transport created_by: midori creation_date: 2010-12-16T04:11:02Z [Term] id: GO:0072512 name: trivalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] is_a: GO:0006812 ! cation transport created_by: midori creation_date: 2010-12-16T04:12:40Z [Term] id: GO:0072513 name: positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:BHF, GOC:mah, GOC:rl] synonym: "negative regulation of second heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0003266 ! regulation of secondary heart field cardioblast proliferation is_a: GO:0008284 ! positive regulation of cell population proliferation created_by: midori creation_date: 2010-12-17T10:16:43Z [Term] id: GO:0072514 name: trehalose transport in response to water deprivation namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water." [GOC:mah] is_a: GO:0015771 ! trehalose transport relationship: part_of GO:0042631 ! cellular response to water deprivation created_by: midori creation_date: 2010-12-21T11:26:14Z [Term] id: GO:0072515 name: trehalose transport in response to desiccation namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] is_a: GO:0072514 ! trehalose transport in response to water deprivation relationship: part_of GO:0071465 ! cellular response to desiccation created_by: midori creation_date: 2010-12-21T11:30:31Z [Term] id: GO:0072516 name: viral assembly compartment namespace: cellular_component def: "A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place." [GOC:BHF, PMID:20374631] synonym: "viral assembly site" RELATED [GOC:BHF] synonym: "virion assembly compartment" EXACT [GOC:mah] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm created_by: midori creation_date: 2010-12-21T03:08:42Z [Term] id: GO:0072517 name: host cell viral assembly compartment namespace: cellular_component def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631] synonym: "host cell viral assembly site" RELATED [GOC:BHF] synonym: "host cell virion assembly compartment" EXACT [GOC:mah] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0039714 ! cytoplasmic viral factory created_by: midori creation_date: 2010-12-21T03:14:06Z [Term] id: GO:0072518 name: Rho-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho." [GOC:ecd, PMID:12778124, PMID:20230755] synonym: "Rho-associated protein kinase activity" EXACT [GOC:ecd] synonym: "ROCK kinase activity" EXACT [GOC:ecd] is_a: GO:0004674 ! protein serine/threonine kinase activity created_by: midori creation_date: 2010-12-22T11:07:29Z [Term] id: GO:0072520 name: seminiferous tubule development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0008584 ! male gonad development created_by: midori creation_date: 2011-01-04T12:50:36Z [Term] id: GO:0072521 name: purine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative metabolic process" EXACT [] synonym: "purine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: midori creation_date: 2011-01-04T03:03:59Z [Term] id: GO:0072522 name: purine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative biosynthetic process" EXACT [] synonym: "purine-containing compound anabolism" EXACT [GOC:mah] synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "purine-containing compound formation" EXACT [GOC:mah] synonym: "purine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072521 ! purine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: midori creation_date: 2011-01-04T03:15:29Z [Term] id: GO:0072523 name: purine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative catabolic process" EXACT [] synonym: "purine-containing compound breakdown" EXACT [GOC:mah] synonym: "purine-containing compound catabolism" EXACT [GOC:mah] synonym: "purine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072521 ! purine-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: midori creation_date: 2011-01-04T03:17:20Z [Term] id: GO:0072524 name: pyridine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative metabolic process" EXACT [] synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: midori creation_date: 2011-01-04T03:21:47Z [Term] id: GO:0072525 name: pyridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative biosynthetic process" EXACT [] synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyridine-containing compound formation" EXACT [GOC:mah] synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072524 ! pyridine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: midori creation_date: 2011-01-04T03:23:01Z [Term] id: GO:0072526 name: pyridine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative catabolic process" EXACT [] synonym: "pyridine-containing compound breakdown" EXACT [GOC:mah] synonym: "pyridine-containing compound catabolism" EXACT [GOC:mah] synonym: "pyridine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: midori creation_date: 2011-01-04T03:23:14Z [Term] id: GO:0072527 name: pyrimidine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative metabolic process" EXACT [] synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: midori creation_date: 2011-01-04T03:27:19Z [Term] id: GO:0072528 name: pyrimidine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative biosynthetic process" EXACT [] synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah] synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: midori creation_date: 2011-01-04T03:27:36Z [Term] id: GO:0072529 name: pyrimidine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative catabolic process" EXACT [] synonym: "pyrimidine-containing compound breakdown" EXACT [GOC:mah] synonym: "pyrimidine-containing compound catabolism" EXACT [GOC:mah] synonym: "pyrimidine-containing compound degradation" EXACT [GOC:mah] is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: midori creation_date: 2011-01-04T03:27:51Z [Term] id: GO:0072530 name: purine-containing compound transmembrane transport namespace: biological_process def: "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "purine-containing compound membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport created_by: midori creation_date: 2011-01-05T01:45:14Z [Term] id: GO:0072531 name: pyrimidine-containing compound transmembrane transport namespace: biological_process def: "The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pyrimidine-containing compound membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport created_by: midori creation_date: 2011-01-05T01:47:22Z [Term] id: GO:0072532 name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives." [GOC:kad, PMID:19779199] comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986). is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: midori creation_date: 2011-01-12T01:54:31Z [Term] id: GO:0072533 name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives." [GOC:kad, PMID:19779199] comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260). is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: midori creation_date: 2011-01-12T02:03:07Z [Term] id: GO:0072534 name: perineuronal net namespace: cellular_component def: "A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019] synonym: "PNN" EXACT [GOC:sl] is_a: GO:0098966 ! perisynaptic extracellular matrix created_by: midori creation_date: 2011-01-14T01:37:40Z [Term] id: GO:0072535 name: tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "RANKL production" EXACT [GOC:ebc, PR:000002107] synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107] synonym: "tumor necrosis factor ligand superfamily member 11 production" EXACT [GOC:bf, PR:000002107] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production created_by: midori creation_date: 2011-01-14T01:42:23Z [Term] id: GO:0072536 name: interleukin-23 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:BHF, GOC:mah, PMID:12023369] synonym: "IL-23 receptor complex" EXACT [GOC:mah] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: midori creation_date: 2011-01-14T02:51:14Z [Term] id: GO:0072537 name: fibroblast activation namespace: biological_process def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah] is_a: GO:0001775 ! cell activation created_by: midori creation_date: 2011-01-14T04:35:08Z [Term] id: GO:0072538 name: T-helper 17 type immune response namespace: biological_process def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc] synonym: "Th17 immune response" EXACT [GOC:mah] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains created_by: midori creation_date: 2011-01-17T11:13:53Z [Term] id: GO:0072539 name: T-helper 17 cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T-helper 17 cell development" RELATED [GOC:mah] is_a: GO:0042093 ! T-helper cell differentiation relationship: part_of GO:0072538 ! T-helper 17 type immune response created_by: midori creation_date: 2011-01-17T11:18:47Z [Term] id: GO:0072540 name: T-helper 17 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] synonym: "T-helper 17 cell fate commitment" EXACT [GOC:mah] synonym: "Th17 cell lineage commitment" EXACT [CL:0000899, GOC:mah] synonym: "Th17 fate commitment" EXACT [CL:0000899] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0072539 ! T-helper 17 cell differentiation created_by: midori creation_date: 2011-01-17T11:19:48Z [Term] id: GO:0072541 name: peroxynitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O." [GOC:rs, PMID:11001062] comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent. synonym: "peroxynitritase activity" EXACT [GOC:rs] is_a: GO:0051920 ! peroxiredoxin activity created_by: midori creation_date: 2011-01-17T11:43:37Z [Term] id: GO:0072542 name: protein phosphatase activator activity namespace: molecular_function alt_id: GO:0071862 alt_id: GO:0072543 def: "Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:mah] synonym: "protein phosphatase 2 activator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase type 1 activator activity" NARROW [] synonym: "protein phosphatase type 2A activator activity" NARROW [] is_a: GO:0019211 ! phosphatase activator activity is_a: GO:0019888 ! protein phosphatase regulator activity created_by: midori creation_date: 2010-09-10T03:39:56Z [Term] id: GO:0072544 name: L-DOPA binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [CHEBI:15765, GOC:mah, GOC:vw] synonym: "L-dopa binding" EXACT [CHEBI:15765] is_a: GO:0008144 ! drug binding is_a: GO:0016597 ! amino acid binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:0097159 ! organic cyclic compound binding created_by: midori creation_date: 2011-01-19T05:40:04Z [Term] id: GO:0072545 name: tyrosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid." [CHEBI:18186, GOC:mah] synonym: "Tyr binding" EXACT [GOC:mah] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding is_a: GO:0097159 ! organic cyclic compound binding created_by: midori creation_date: 2011-01-19T05:43:55Z [Term] id: GO:0072546 name: ER membrane protein complex namespace: cellular_component def: "A transmembrane protein complex located in the ER that is involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [GOC:dgf, GOC:krc, GOC:vw, PMID:19325107, PMID:25313861] synonym: "EMC" EXACT [] synonym: "endoplasmic reticulum membrane protein complex" EXACT [GOC:mah] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane created_by: midori creation_date: 2011-01-19T06:16:53Z [Term] id: GO:0072547 name: tricoumaroylspermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] synonym: "tricoumaroyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] xref: MetaCyc:RXN-11260 is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T02:49:37Z [Term] id: GO:0072548 name: dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T02:57:22Z [Term] id: GO:0072549 name: monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T02:58:04Z [Term] id: GO:0072550 name: triferuloylspermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] synonym: "triferuloyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] xref: MetaCyc:RXN-11262 is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T02:58:56Z [Term] id: GO:0072551 name: diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T03:04:16Z [Term] id: GO:0072552 name: monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity created_by: midori creation_date: 2011-01-25T03:15:31Z [Term] id: GO:0072553 name: terminal button organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah] synonym: "bouton organization" EXACT [GOC:mah] synonym: "presynaptic bouton organization" EXACT [GOC:mah] synonym: "synaptic bouton organization" EXACT [GOC:mah] synonym: "terminal bouton organization" EXACT [GOC:mah] synonym: "terminal button organisation" EXACT [GOC:mah] is_a: GO:0099172 ! presynapse organization created_by: midori creation_date: 2011-01-25T04:09:35Z [Term] id: GO:0072554 name: blood vessel lumenization namespace: biological_process def: "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow." [GOC:dsf, PMID:16799567, PMID:20926893] is_a: GO:0061154 ! endothelial tube morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: midori creation_date: 2011-01-25T05:19:30Z [Term] id: GO:0072555 name: 17-beta-ketosteroid reductase activity namespace: molecular_function def: "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+." [GOC:kad, PMID:17074428] synonym: "17-beta-ketosteroid reductase (NADPH) activity" EXACT [GOC:kad] synonym: "7beta-ketosteroid reductase activity" EXACT [GOC:kad] is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: midori creation_date: 2011-01-27T11:36:14Z [Term] id: GO:0072557 name: IPAF inflammasome complex namespace: cellular_component def: "A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] is_a: GO:0061702 ! inflammasome complex created_by: midori creation_date: 2011-01-27T12:01:44Z [Term] id: GO:0072558 name: NLRP1 inflammasome complex namespace: cellular_component def: "A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] synonym: "NALP1 inflammasome complex" EXACT [] is_a: GO:0061702 ! inflammasome complex created_by: midori creation_date: 2011-01-27T12:03:50Z [Term] id: GO:0072559 name: NLRP3 inflammasome complex namespace: cellular_component def: "A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] synonym: "NALP3 inflammasome complex" EXACT [] is_a: GO:0061702 ! inflammasome complex created_by: midori creation_date: 2011-01-27T12:04:30Z [Term] id: GO:0072560 name: type B pancreatic cell maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] comment: These processes continue to 60 DPA in Gossypium spp. synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] is_a: GO:0002071 ! glandular epithelial cell maturation relationship: part_of GO:0003323 ! type B pancreatic cell development created_by: midori creation_date: 2011-01-27T01:57:14Z [Term] id: GO:0072562 name: blood microparticle namespace: cellular_component def: "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184] synonym: "cell membrane microparticle" EXACT [PMID:16373184] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005615 ! extracellular space created_by: midori creation_date: 2011-01-28T11:50:56Z [Term] id: GO:0072563 name: endothelial microparticle namespace: cellular_component def: "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] is_a: GO:0072562 ! blood microparticle created_by: midori creation_date: 2011-01-28T01:53:25Z [Term] id: GO:0072564 name: blood microparticle formation namespace: biological_process def: "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell." [GOC:BHF, GOC:mah, PMID:16373184] synonym: "microparticle generation" EXACT [PMID:20978343] synonym: "microparticle release" EXACT [PMID:16373184] is_a: GO:0016043 ! cellular component organization is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis created_by: midori creation_date: 2011-01-28T02:15:50Z [Term] id: GO:0072565 name: endothelial microparticle formation namespace: biological_process def: "The cellular component organization process in which microparticles bud off from an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] synonym: "endothelial microparticle generation" EXACT [GOC:mah, PMID:20978343] synonym: "endothelial microparticle release" EXACT [GOC:mah, PMID:16373184] is_a: GO:0072564 ! blood microparticle formation created_by: midori creation_date: 2011-01-28T02:21:58Z [Term] id: GO:0072566 name: chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "CXCL1 production" EXACT [GOC:BHF] synonym: "KC production" EXACT [GOC:BHF] synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF] synonym: "SCYB1 production" EXACT [GOC:BHF] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2011-01-31T11:31:58Z [Term] id: GO:0072567 name: chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] synonym: "CXCL2 production" EXACT [GOC:mah] synonym: "MIP-2 production" EXACT [GOC:BHF] synonym: "MIP2 production" EXACT [GOC:BHF] synonym: "SCYB2 production" EXACT [GOC:BHF] is_a: GO:0032602 ! chemokine production created_by: midori creation_date: 2011-01-31T11:33:40Z [Term] id: GO:0072570 name: ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964] synonym: "ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0043168 ! anion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding created_by: midori creation_date: 2011-01-31T02:37:30Z [Term] id: GO:0072571 name: mono-ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [CHEBI:16864, GOC:mah, GOC:sart, PMID:20088964] synonym: "mADPr binding" EXACT [PMID:20088964] synonym: "mono-ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0072570 ! ADP-D-ribose binding created_by: midori creation_date: 2011-01-31T02:39:12Z [Term] id: GO:0072572 name: poly-ADP-D-ribose binding namespace: molecular_function def: "Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [CHEBI:61151, GOC:mah, GOC:sart, PMID:20088964] synonym: "pADPr binding" EXACT [PMID:20088964] synonym: "poly-ADP-ribose binding" BROAD [GOC:mah] is_a: GO:0097367 ! carbohydrate derivative binding created_by: midori creation_date: 2011-01-31T02:49:04Z [Term] id: GO:0072573 name: tolerance induction to lipopolysaccharide namespace: biological_process def: "Tolerance induction directed at lipopolysaccharide antigens." [GOC:BHF, GOC:mah] synonym: "tolerance induction to endotoxin" BROAD [GOC:add, GOC:mah] synonym: "tolerance induction to LPS" EXACT [GOC:add, GOC:mah] is_a: GO:0002507 ! tolerance induction is_a: GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide created_by: midori creation_date: 2011-02-02T03:05:19Z [Term] id: GO:0072574 name: hepatocyte proliferation namespace: biological_process def: "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [CL:0000182, GOC:BHF, GOC:mah] is_a: GO:0072575 ! epithelial cell proliferation involved in liver morphogenesis created_by: midori creation_date: 2011-02-02T03:34:49Z [Term] id: GO:0072575 name: epithelial cell proliferation involved in liver morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0072576 ! liver morphogenesis relationship: part_of GO:0072576 ! liver morphogenesis created_by: midori creation_date: 2011-02-02T03:37:50Z [Term] id: GO:0072576 name: liver morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0001889 ! liver development created_by: midori creation_date: 2011-02-02T03:41:30Z [Term] id: GO:0072577 name: endothelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] synonym: "endothelial cell apoptosis" NARROW [] synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of endothelial cells" EXACT [GOC:mah] synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: midori creation_date: 2011-02-02T03:56:24Z [Term] id: GO:0072578 name: neurotransmitter-gated ion channel clustering namespace: biological_process def: "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816] is_a: GO:0043113 ! receptor clustering relationship: part_of GO:0050808 ! synapse organization created_by: midori creation_date: 2011-02-03T01:45:48Z [Term] id: GO:0072579 name: glycine receptor clustering namespace: biological_process def: "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane." [GOC:dsf, GOC:mah, GOC:pr, PMID:20843816] is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering relationship: part_of GO:0001941 ! postsynaptic membrane organization created_by: midori creation_date: 2011-02-03T01:47:40Z [Term] id: GO:0072580 name: bacterial-type EF-P lysine modification namespace: biological_process def: "The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P)." [GOC:curators, GOC:imk, GOC:mah, PMID:20729861, PMID:22706199, RESID:AA0530, RESID:AA0531] comment: The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34. synonym: "EF-P modification pathway" EXACT [PMID:22706199] is_a: GO:0018205 ! peptidyl-lysine modification created_by: midori creation_date: 2011-02-07T11:47:33Z [Term] id: GO:0072581 name: protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine namespace: biological_process def: "The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531] is_a: GO:0018205 ! peptidyl-lysine modification relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification created_by: midori creation_date: 2011-02-07T11:51:02Z [Term] id: GO:0072582 name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+." [GOC:kad, PMID:17074428] xref: RHEA:24616 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: midori creation_date: 2011-02-07T01:54:21Z [Term] id: GO:0072583 name: clathrin-dependent endocytosis namespace: biological_process def: "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] synonym: "clathrin coated pit-dependent endocytosis" EXACT [GOC:BHF] synonym: "clathrin-dependent endocytosis" EXACT [GOC:mah] synonym: "clathrin-mediated endocytosis" EXACT [] synonym: "CME" EXACT [PMID:20074057] is_a: GO:0006898 ! receptor-mediated endocytosis created_by: midori creation_date: 2011-02-08T03:59:18Z [Term] id: GO:0072584 name: caveolin-mediated endocytosis namespace: biological_process def: "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers." [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965] synonym: "caveolae-dependent endocytosis" EXACT [GOC:mah] synonym: "caveolae-mediated endocytosis" EXACT [GOC:mah] synonym: "caveolin-dependent endocytosis" EXACT [GOC:BHF] is_a: GO:0006897 ! endocytosis created_by: midori creation_date: 2011-02-08T04:08:33Z [Term] id: GO:0072585 name: xanthosine nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647] synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad] xref: MetaCyc:RXN0-363 is_a: GO:0008477 ! purine nucleosidase activity created_by: midori creation_date: 2011-02-08T04:38:31Z [Term] id: GO:0072586 name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity namespace: molecular_function def: "Modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] is_a: GO:0060590 ! ATPase regulator activity relationship: part_of GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity relationship: regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity created_by: midori creation_date: 2011-02-09T05:31:50Z [Term] id: GO:0072587 name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity namespace: molecular_function def: "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] is_a: GO:0001671 ! ATPase activator activity is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity relationship: part_of GO:2000373 ! positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity relationship: positively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity created_by: midori creation_date: 2011-02-09T05:34:47Z [Term] id: GO:0072588 name: box H/ACA RNP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365] synonym: "box H/ACA snoRNP pseudouridylase complex" RELATED [GOC:mah] synonym: "sRNP complex" NARROW [GOC:mah, PMID:17284456, PMID:20227365] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex created_by: midori creation_date: 2011-02-10T01:43:37Z [Term] id: GO:0072589 name: box H/ACA scaRNP complex namespace: cellular_component def: "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs." [GOC:mah, PMID:17284456, PMID:20227365] synonym: "nucleoplasmic box H/ACA RNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:20227365] is_a: GO:0072588 ! box H/ACA RNP complex is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0015030 ! Cajal body created_by: midori creation_date: 2011-02-10T02:47:17Z [Term] id: GO:0072590 name: N-acetyl-L-aspartate-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate." [PMID:20643647, PMID:20657015] xref: Reactome:R-HSA-8942575 "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds created_by: midori creation_date: 2011-02-10T03:20:41Z [Term] id: GO:0072591 name: citrate-L-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate." [PMID:20657015] is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds created_by: midori creation_date: 2011-02-10T03:24:26Z [Term] id: GO:0072592 name: oxygen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [CHEBI:33263, GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] is_a: GO:0017144 ! drug metabolic process created_by: midori creation_date: 2011-02-11T10:46:51Z [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [CHEBI:26523, GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: GO:0044237 ! cellular metabolic process created_by: midori creation_date: 2011-02-11T10:50:06Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0045184 ! establishment of protein localization created_by: midori creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072595 name: maintenance of protein localization in organelle namespace: biological_process def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah] synonym: "maintenance of protein localization to organelle" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0043226 ! organelle relationship: occurs_in GO:0043226 ! organelle relationship: part_of GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2011-02-14T02:09:13Z [Term] id: GO:0072596 name: establishment of protein localization to chloroplast namespace: biological_process def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah] synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072598 ! protein localization to chloroplast created_by: midori creation_date: 2011-02-14T02:16:13Z [Term] id: GO:0072597 name: maintenance of protein location in chloroplast namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0009507 ! chloroplast relationship: occurs_in GO:0009507 ! chloroplast relationship: part_of GO:0072598 ! protein localization to chloroplast created_by: midori creation_date: 2011-02-14T02:17:48Z [Term] id: GO:0072598 name: protein localization to chloroplast namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd] synonym: "protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2011-02-14T02:20:30Z [Term] id: GO:0072599 name: establishment of protein localization to endoplasmic reticulum namespace: biological_process def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah] synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah] synonym: "establishment of protein localisation to ER" EXACT [GOC:mah] synonym: "establishment of protein localization in endoplasmic reticulum" EXACT [] synonym: "establishment of protein localization to ER" EXACT [GOC:mah] is_a: GO:0070972 ! protein localization to endoplasmic reticulum is_a: GO:0072594 ! establishment of protein localization to organelle created_by: midori creation_date: 2011-02-14T02:23:41Z [Term] id: GO:0072601 name: interleukin-3 secretion namespace: biological_process def: "The regulated release of interleukin-3 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-3 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032632 ! interleukin-3 production [Term] id: GO:0072602 name: interleukin-4 secretion namespace: biological_process def: "The regulated release of interleukin-4 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-4 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032633 ! interleukin-4 production [Term] id: GO:0072603 name: interleukin-5 secretion namespace: biological_process def: "The regulated release of interleukin-5 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-5 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032634 ! interleukin-5 production [Term] id: GO:0072604 name: interleukin-6 secretion namespace: biological_process def: "The regulated release of interleukin-6 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-6 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032635 ! interleukin-6 production [Term] id: GO:0072605 name: interleukin-7 secretion namespace: biological_process def: "The regulated release of interleukin-7 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-7 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032636 ! interleukin-7 production [Term] id: GO:0072606 name: interleukin-8 secretion namespace: biological_process def: "The regulated release of interleukin-8 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-8 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032637 ! interleukin-8 production [Term] id: GO:0072607 name: interleukin-9 secretion namespace: biological_process def: "The regulated release of interleukin-9 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-9 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032638 ! interleukin-9 production [Term] id: GO:0072608 name: interleukin-10 secretion namespace: biological_process def: "The regulated release of interleukin-10 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-10 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032613 ! interleukin-10 production [Term] id: GO:0072609 name: interleukin-11 secretion namespace: biological_process def: "The regulated release of interleukin-11 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-11 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032614 ! interleukin-11 production [Term] id: GO:0072610 name: interleukin-12 secretion namespace: biological_process def: "The regulated release of interleukin-12 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "CLMF secretion" NARROW [GOC:BHF] synonym: "IL-12 secretion" EXACT [GOC:BHF] synonym: "IL12 secretion" EXACT [GOC:BHF] synonym: "interleukin-12 complex secretion" EXACT [GOC:BHF] synonym: "NKSF secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032615 ! interleukin-12 production [Term] id: GO:0072611 name: interleukin-13 secretion namespace: biological_process def: "The regulated release of interleukin-13 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-13 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032616 ! interleukin-13 production [Term] id: GO:0072612 name: interleukin-14 secretion namespace: biological_process def: "The regulated release of interleukin-14 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-14 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032617 ! interleukin-14 production [Term] id: GO:0072613 name: interleukin-15 secretion namespace: biological_process def: "The regulated release of interleukin-15 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-15 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032618 ! interleukin-15 production [Term] id: GO:0072614 name: interleukin-16 secretion namespace: biological_process def: "The regulated release of interleukin-16 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-16 secretion" EXACT [GOC:BHF] synonym: "IL16 secretion" EXACT [GOC:BHF] synonym: "LCF secretion" NARROW [GOC:BHF] synonym: "pro-interleukin-16 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032619 ! interleukin-16 production [Term] id: GO:0072615 name: interleukin-17 secretion namespace: biological_process def: "The regulated release of any member of the interleukin-17 family of cytokines from a cell." [GOC:add, GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "CTLA-8 secretion" EXACT [GOC:BHF] synonym: "Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:BHF] synonym: "IL-17 secretion" EXACT [GOC:BHF] synonym: "IL-17A secretion" EXACT [GOC:BHF] synonym: "IL17A secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032620 ! interleukin-17 production [Term] id: GO:0072616 name: interleukin-18 secretion namespace: biological_process def: "The regulated release of interleukin-18 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IGIF secretion" EXACT [GOC:BHF] synonym: "IL-18 secretion" EXACT [GOC:BHF] synonym: "IL1F4 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032621 ! interleukin-18 production [Term] id: GO:0072617 name: interleukin-19 secretion namespace: biological_process def: "The regulated release of interleukin-19 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-19 secretion" EXACT [GOC:BHF] synonym: "ZMDA1 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032622 ! interleukin-19 production [Term] id: GO:0072618 name: interleukin-20 secretion namespace: biological_process def: "The regulated release of interleukin-20 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-20 secretion" EXACT [GOC:BHF] synonym: "ZCYTO10 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032624 ! interleukin-20 production [Term] id: GO:0072619 name: interleukin-21 secretion namespace: biological_process def: "The regulated release of interleukin-21 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-21 secretion" EXACT [GOC:BHF] synonym: "IL21 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032625 ! interleukin-21 production [Term] id: GO:0072620 name: interleukin-22 secretion namespace: biological_process def: "The regulated release of interleukin-22 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-22 secretion" EXACT [GOC:BHF] synonym: "IL22 secretion" EXACT [GOC:BHF] synonym: "ILTIF secretion" EXACT [GOC:BHF] synonym: "ZCYTO18 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032626 ! interleukin-22 production [Term] id: GO:0072621 name: interleukin-23 secretion namespace: biological_process def: "The regulated release of interleukin-23 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-23 secretion" EXACT [GOC:BHF] synonym: "IL23 secretion" EXACT [GOC:BHF] synonym: "interleukin-23 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032627 ! interleukin-23 production [Term] id: GO:0072622 name: interleukin-24 secretion namespace: biological_process def: "The regulated release of interleukin-24 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-24 secretion" EXACT [GOC:BHF] synonym: "IL24 secretion" EXACT [GOC:BHF] synonym: "MDA7 secretion" EXACT [GOC:BHF] synonym: "ST16 secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032628 ! interleukin-24 production [Term] id: GO:0072623 name: interleukin-25 secretion namespace: biological_process def: "The regulated release of interleukin-25 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-25 secretion" EXACT [GOC:BHF] synonym: "IL17E secretion" EXACT [GOC:BHF] synonym: "IL25 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032629 ! interleukin-25 production [Term] id: GO:0072624 name: interleukin-26 secretion namespace: biological_process def: "The regulated release of interleukin-26 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "AK155 secretion" NARROW [GOC:BHF] synonym: "IL-26 secretion" EXACT [GOC:BHF] synonym: "IL26 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032630 ! interleukin-26 production [Term] id: GO:0072625 name: interleukin-27 secretion namespace: biological_process def: "The regulated release of interleukin-27 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-27 secretion" EXACT [GOC:BHF] synonym: "IL27 secretion" EXACT [GOC:BHF] synonym: "interleukin-27 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032631 ! interleukin-27 production [Term] id: GO:0072626 name: interleukin-35 secretion namespace: biological_process def: "The regulated release of interleukin-35 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-35 secretion" EXACT [GOC:BHF] synonym: "IL35 secretion" EXACT [GOC:BHF] synonym: "interleukin-35 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0070753 ! interleukin-35 production [Term] id: GO:0072627 name: interleukin-28A production namespace: biological_process def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28A production" EXACT [GOC:BHF] synonym: "IL28A production" EXACT [GOC:BHF] synonym: "interferon lambda 2 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072628 name: interleukin-28A secretion namespace: biological_process def: "The regulated release of interleukin-28A from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28A secretion" EXACT [GOC:BHF] synonym: "IL28A secretion" EXACT [GOC:BHF] synonym: "interferon lambda 2 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072627 ! interleukin-28A production [Term] id: GO:0072629 name: interleukin-28B production namespace: biological_process def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28B production" EXACT [GOC:BHF] synonym: "IL28B production" EXACT [GOC:BHF] synonym: "interferon lambda 3 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072630 name: interleukin-28B secretion namespace: biological_process def: "The regulated release of interleukin-28B from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-28B secretion" EXACT [GOC:BHF] synonym: "IL28B secretion" EXACT [GOC:BHF] synonym: "interferon lambda 3 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072629 ! interleukin-28B production [Term] id: GO:0072631 name: interleukin-29 production namespace: biological_process def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-29 production" EXACT [GOC:BHF] synonym: "IL29 production" EXACT [GOC:BHF] synonym: "interferon lambda 1 production" EXACT [GOC:BHF] is_a: GO:0034343 ! type III interferon production [Term] id: GO:0072632 name: interleukin-29 secretion namespace: biological_process def: "The regulated release of interleukin-29 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-29 secretion" EXACT [GOC:BHF] synonym: "IL29 secretion" EXACT [GOC:BHF] synonym: "interferon lambda 1 secretion" EXACT [GOC:BHF] is_a: GO:0072644 ! type III interferon secretion relationship: part_of GO:0072631 ! interleukin-29 production [Term] id: GO:0072633 name: interleukin-30 production namespace: biological_process def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-30 production" EXACT [GOC:BHF] synonym: "interleukin-30 complex production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072634 name: interleukin-30 secretion namespace: biological_process def: "The regulated release of interleukin-30 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-30 secretion" EXACT [GOC:BHF] synonym: "interleukin-30 complex secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072633 ! interleukin-30 production [Term] id: GO:0072635 name: interleukin-31 production namespace: biological_process def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-31 production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072636 name: interleukin-31 secretion namespace: biological_process def: "The regulated release of interleukin-31 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-31 secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072635 ! interleukin-31 production [Term] id: GO:0072637 name: interleukin-32 production namespace: biological_process def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-32 production" EXACT [GOC:BHF] synonym: "IL32 production" EXACT [GOC:BHF] synonym: "NK4 production" NARROW [GOC:BHF] synonym: "TAIF production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072638 name: interleukin-32 secretion namespace: biological_process def: "The regulated release of interleukin-32 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-32 secretion" EXACT [GOC:BHF] synonym: "IL32 secretion" EXACT [GOC:BHF] synonym: "NK4 secretion" NARROW [GOC:BHF] synonym: "TAIF secretion" NARROW [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072637 ! interleukin-32 production [Term] id: GO:0072639 name: interleukin-33 production namespace: biological_process def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "C9orf26 production" NARROW [GOC:BHF] synonym: "IL-33 production" EXACT [GOC:BHF] synonym: "IL1F11 production" NARROW [GOC:BHF] synonym: "IL33 production" EXACT [GOC:BHF] synonym: "NF-HEV production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0072640 name: interleukin-33 secretion namespace: biological_process def: "The regulated release of interleukin-33 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "C9orf26 secretion" NARROW [GOC:BHF] synonym: "IL-33 secretion" EXACT [GOC:BHF] synonym: "IL1F11 secretion" NARROW [GOC:BHF] synonym: "IL33 secretion" EXACT [GOC:BHF] synonym: "NF-HEV secretion" EXACT [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0072639 ! interleukin-33 production [Term] id: GO:0072641 name: type I interferon secretion namespace: biological_process def: "The regulated release of type I interferon from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "type I IFN secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032606 ! type I interferon production [Term] id: GO:0072642 name: interferon-alpha secretion namespace: biological_process def: "The regulated release of interferon-alpha from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-alpha secretion" EXACT [GOC:mah] synonym: "IFNA secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0032607 ! interferon-alpha production [Term] id: GO:0072643 name: interferon-gamma secretion namespace: biological_process def: "The regulated release of interferon-gamma from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-gamma secretion" EXACT [GOC:mah] synonym: "IFNG secretion" EXACT [GOC:BHF] synonym: "type II IFN secretion" BROAD [GOC:mah] synonym: "type II interferon secretion" BROAD [GOC:BHF] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032609 ! interferon-gamma production [Term] id: GO:0072644 name: type III interferon secretion namespace: biological_process def: "The regulated release of type III interferon from a cell. Interferon lambda is the only member of the type III interferon found so far." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "type III IFN secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0034343 ! type III interferon production [Term] id: GO:0072645 name: interferon-delta production namespace: biological_process def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-delta production" EXACT [GOC:mah] synonym: "IFND production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072646 name: interferon-delta secretion namespace: biological_process def: "The regulated release of interferon-delta from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-delta secretion" EXACT [GOC:mah] synonym: "IFND secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072645 ! interferon-delta production [Term] id: GO:0072647 name: interferon-epsilon production namespace: biological_process def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-epsilon production" EXACT [GOC:mah] synonym: "IFNE production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072648 name: interferon-epsilon secretion namespace: biological_process def: "The regulated release of interferon-epsilon from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-epsilon secretion" EXACT [GOC:mah] synonym: "IFNE secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072647 ! interferon-epsilon production [Term] id: GO:0072649 name: interferon-kappa production namespace: biological_process def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-kappa production" EXACT [GOC:mah] synonym: "IFNK production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072650 name: interferon-kappa secretion namespace: biological_process def: "The regulated release of interferon-kappa from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-kappa secretion" EXACT [GOC:mah] synonym: "IFNK secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072649 ! interferon-kappa production [Term] id: GO:0072651 name: interferon-tau production namespace: biological_process def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-tau production" EXACT [GOC:mah] synonym: "IFNT production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072652 name: interferon-tau secretion namespace: biological_process def: "The regulated release of interferon-tau from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-tau secretion" EXACT [GOC:mah] synonym: "IFNT secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072651 ! interferon-tau production [Term] id: GO:0072653 name: interferon-omega production namespace: biological_process def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-omega production" EXACT [GOC:mah] synonym: "IFNW production" EXACT [GOC:BHF] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0072654 name: interferon-omega secretion namespace: biological_process def: "The regulated release of interferon-omega from a cell." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-omega secretion" EXACT [GOC:mah] synonym: "IFNW secretion" EXACT [GOC:BHF] is_a: GO:0072641 ! type I interferon secretion relationship: part_of GO:0072653 ! interferon-omega production [Term] id: GO:0072655 name: establishment of protein localization to mitochondrion namespace: biological_process def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrion" EXACT [] is_a: GO:0070585 ! protein localization to mitochondrion is_a: GO:0072594 ! establishment of protein localization to organelle created_by: midori creation_date: 2011-02-14T02:28:54Z [Term] id: GO:0072656 name: maintenance of protein location in mitochondrion namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0070585 ! protein localization to mitochondrion created_by: midori creation_date: 2011-02-14T02:30:43Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] is_a: GO:0034613 ! cellular protein localization created_by: midori creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072658 name: maintenance of protein location in membrane namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0072657 ! protein localization to membrane created_by: midori creation_date: 2011-02-14T02:39:41Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process alt_id: GO:0072661 alt_id: GO:0090002 def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] subset: goslim_pombe synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "protein localization in plasma membrane" RELATED [] synonym: "protein targeting to plasma membrane" RELATED [] synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery created_by: tanyaberardini creation_date: 2009-07-10T10:29:23Z [Term] id: GO:0072660 name: maintenance of protein location in plasma membrane namespace: biological_process def: "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072658 ! maintenance of protein location in membrane relationship: part_of GO:0072659 ! protein localization to plasma membrane created_by: midori creation_date: 2011-02-14T02:46:08Z [Term] id: GO:0072662 name: protein localization to peroxisome namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome." [GOC:ecd] synonym: "protein localisation to peroxisome" EXACT [GOC:mah] is_a: GO:0007031 ! peroxisome organization is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2011-02-14T02:50:04Z [Term] id: GO:0072663 name: establishment of protein localization to peroxisome namespace: biological_process def: "The directed movement of a protein to a specific location in a peroxisome." [GOC:mah] synonym: "establishment of protein localisation to peroxisome" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072662 ! protein localization to peroxisome created_by: midori creation_date: 2011-02-14T02:50:36Z [Term] id: GO:0072664 name: maintenance of protein location in peroxisome namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005777 ! peroxisome relationship: occurs_in GO:0005777 ! peroxisome relationship: part_of GO:0072662 ! protein localization to peroxisome created_by: midori creation_date: 2011-02-14T02:51:51Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle created_by: midori creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072665 ! protein localization to vacuole created_by: midori creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072667 name: maintenance of protein location in vacuole namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole relationship: part_of GO:0072665 ! protein localization to vacuole created_by: midori creation_date: 2011-02-14T02:56:57Z [Term] id: GO:0072668 name: obsolete tubulin complex biogenesis namespace: biological_process def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled." [GOC:mah] comment: This term was obsoleted becuase biogenesis should only be used for complexes where synthesis of some non-protein component is necessary for assembly. synonym: "tubulin complex biogenesis" EXACT [] is_obsolete: true replaced_by: GO:0007021 created_by: midori creation_date: 2011-02-14T03:25:18Z [Term] id: GO:0072669 name: tRNA-splicing ligase complex namespace: cellular_component def: "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021] synonym: "tRNA splicing ligase complex" EXACT [GOC:mah] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: midori creation_date: 2011-02-18T10:55:26Z [Term] id: GO:0072670 name: mitochondrial tRNA threonylcarbamoyladenosine modification namespace: biological_process def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base)." [GOC:mcc, PMID:21183954] synonym: "mitochondrial tRNA t6A modification" EXACT [GOC:mcc] is_a: GO:0002949 ! tRNA threonylcarbamoyladenosine modification is_a: GO:0070900 ! mitochondrial tRNA modification created_by: midori creation_date: 2011-02-18T11:34:35Z [Term] id: GO:0072671 name: mitochondria-associated ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions." [GOC:mcc, PMID:21070972, PMID:21109188] synonym: "MAD" EXACT [GOC:mcc] synonym: "mitochondria-associated protein catabolic process" EXACT [] synonym: "mitochondria-associated protein degradation" EXACT [GOC:mcc] synonym: "mitochondrion-associated protein catabolic process" EXACT [GOC:mah] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2011-02-18T11:53:28Z [Term] id: GO:0072672 name: neutrophil extravasation namespace: biological_process def: "The migration of a neutrophil from the blood vessels into the surrounding tissue." [CL:0000775, GOC:BHF] is_a: GO:0045123 ! cellular extravasation is_a: GO:1990266 ! neutrophil migration created_by: midori creation_date: 2011-02-21T03:03:52Z [Term] id: GO:0072673 name: lamellipodium morphogenesis namespace: biological_process def: "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized." [GOC:BHF, GOC:mah] synonym: "lamellipodium organization" RELATED [GOC:mah] is_a: GO:0097581 ! lamellipodium organization is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis created_by: midori creation_date: 2011-02-21T03:11:55Z [Term] id: GO:0072674 name: multinuclear osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016] synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah] synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah] is_a: GO:0030316 ! osteoclast differentiation created_by: midori creation_date: 2011-02-22T02:10:38Z [Term] id: GO:0072675 name: osteoclast fusion namespace: biological_process def: "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast." [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0072674 ! multinuclear osteoclast differentiation created_by: midori creation_date: 2011-02-22T02:14:34Z [Term] id: GO:0072676 name: lymphocyte migration namespace: biological_process def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah] is_a: GO:0050900 ! leukocyte migration created_by: midori creation_date: 2011-02-22T03:38:12Z [Term] id: GO:0072677 name: eosinophil migration namespace: biological_process def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah] is_a: GO:0097530 ! granulocyte migration created_by: midori creation_date: 2011-02-22T03:39:31Z [Term] id: GO:0072678 name: T cell migration namespace: biological_process def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte migration" EXACT [CL:0000084] synonym: "T-cell migration" EXACT [CL:0000084] synonym: "T-lymphocyte migration" EXACT [CL:0000084] is_a: GO:0072676 ! lymphocyte migration created_by: midori creation_date: 2011-02-22T03:40:40Z [Term] id: GO:0072679 name: thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah] synonym: "immature T cell migration" RELATED [CL:0000893] synonym: "immature T lymphocyte migration" RELATED [CL:0000893] synonym: "immature T-cell migration" RELATED [CL:0000893] synonym: "immature T-lymphocyte migration" RELATED [CL:0000893] synonym: "thymic lymphocyte migration" EXACT [CL:0000893] is_a: GO:0072678 ! T cell migration created_by: midori creation_date: 2011-02-22T03:47:51Z [Term] id: GO:0072680 name: extracellular matrix-dependent thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] synonym: "extracellular matrix-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "extracellular matrix-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] is_a: GO:0006929 ! substrate-dependent cell migration is_a: GO:0072679 ! thymocyte migration created_by: midori creation_date: 2011-02-22T03:49:57Z [Term] id: GO:0072681 name: fibronectin-dependent thymocyte migration namespace: biological_process def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] synonym: "fibronectin-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] synonym: "fibronectin-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] is_a: GO:0072680 ! extracellular matrix-dependent thymocyte migration created_by: midori creation_date: 2011-02-22T03:53:06Z [Term] id: GO:0072682 name: eosinophil extravasation namespace: biological_process def: "The migration of an eosinophil from the blood vessels into the surrounding tissue." [CL:0000771, GOC:BHF, GOC:mah] is_a: GO:0045123 ! cellular extravasation is_a: GO:0072677 ! eosinophil migration created_by: midori creation_date: 2011-02-22T04:02:22Z [Term] id: GO:0072683 name: T cell extravasation namespace: biological_process def: "The migration of a T cell from the blood vessels into the surrounding tissue." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte extravasation" EXACT [CL:0000084] synonym: "T-cell extravasation" EXACT [CL:0000084] synonym: "T-lymphocyte extravasation" EXACT [CL:0000084] is_a: GO:0045123 ! cellular extravasation is_a: GO:0072678 ! T cell migration created_by: midori creation_date: 2011-02-22T04:05:45Z [Term] id: GO:0072684 name: mitochondrial tRNA 3'-trailer cleavage, endonucleolytic namespace: biological_process def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah] synonym: "mitochondrial endonucleolytic tRNA 3'-end cleavage" EXACT [GOC:mah] synonym: "mitochondrial endonucleolytic tRNA 3'-trailer cleavage" RELATED [GOC:mah] synonym: "mitochondrial tRNA 3'-end cleavage, endonucleolytic" EXACT [GOC:mah] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic intersection_of: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2011-02-23T01:32:52Z [Term] id: GO:0072685 name: Mre11 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838] synonym: "MRN complex assembly" EXACT [GOC:mah] synonym: "MRX complex assembly" EXACT [GOC:mah] synonym: "Rad50 complex assembly" EXACT [GOC:mah] synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah] synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah] synonym: "RMX complex assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: midori creation_date: 2011-05-12T02:52:06Z [Term] id: GO:0072686 name: mitotic spindle namespace: cellular_component def: "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] is_a: GO:0005819 ! spindle created_by: midori creation_date: 2011-07-08T05:08:16Z [Term] id: GO:0072687 name: meiotic spindle namespace: cellular_component def: "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] is_a: GO:0005819 ! spindle created_by: midori creation_date: 2011-07-08T05:17:08Z [Term] id: GO:0072688 name: SHREC complex localization namespace: biological_process def: "Any process in which a SHREC complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of SHREC complex localization" EXACT [GOC:mah] synonym: "SHREC complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization created_by: midori creation_date: 2011-07-20T12:51:49Z [Term] id: GO:0072689 name: MCM complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:mah, PMID:21813639] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: midori creation_date: 2011-08-12T10:57:29Z [Term] id: GO:0072690 name: single-celled organism vegetative growth phase namespace: biological_process def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw] subset: gocheck_do_not_annotate synonym: "vegetative growth of a single-celled organism" EXACT [] is_a: GO:0044848 ! biological phase created_by: midori creation_date: 2011-08-19T12:05:19Z [Term] id: GO:0072691 name: initiation of premeiotic DNA replication namespace: biological_process def: "A process of DNA-dependent DNA replication initiation that occurs as part of premeiotic DNA replication." [GOC:mah, PMID:10888871] synonym: "initiation of meiotic DNA synthesis" RELATED [GOC:mah] synonym: "initiation of premeiotic DNA synthesis" RELATED [GOC:mah] synonym: "meiotic DNA replication initiation" RELATED [GOC:mah] synonym: "premeiotic DNA replication initiation" EXACT [GOC:mah] is_a: GO:1902974 ! meiotic DNA replication initiation intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: midori creation_date: 2011-08-19T03:16:20Z [Term] id: GO:0072692 name: obsolete chromatin silencing at centromere central core namespace: biological_process def: "OBSOLETE. Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin." [GOC:mah] comment: This term was made obsolete because the process does not exist. synonym: "centromere central core chromatin silencing" EXACT [GOC:mah] synonym: "chromatin silencing at centromeric central core" EXACT [GOC:vw] synonym: "chromatin silencing at chromosome kinetochore domain" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere central core" EXACT [GOC:mah] is_obsolete: true created_by: midori creation_date: 2011-09-12T03:16:41Z [Term] id: GO:0072694 name: obsolete cell cycle arrest in response to caffeine namespace: biological_process def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus." [GOC:mah] comment: This term was made obsolete because it does not represent a real process. is_obsolete: true created_by: midori creation_date: 2011-12-05T01:29:00Z [Term] id: GO:0072695 name: regulation of DNA recombination at telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah] synonym: "regulation of telomeric recombination" EXACT [GOC:mah] is_a: GO:0000018 ! regulation of DNA recombination created_by: midori creation_date: 2012-04-03T10:31:50Z [Term] id: GO:0072696 name: positive regulation of DNA recombination at telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah] synonym: "activation of telomeric recombination at telomere" NARROW [GOC:mah] synonym: "positive regulation of telomeric recombination" EXACT [GOC:mah] synonym: "up regulation of telomeric recombination at telomere" EXACT [GOC:mah] synonym: "up-regulation of telomeric recombination at telomere" EXACT [GOC:mah] synonym: "upregulation of telomeric recombination at telomere" EXACT [GOC:mah] is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0072695 ! regulation of DNA recombination at telomere created_by: midori creation_date: 2012-04-03T11:28:19Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery created_by: midori creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0072698 name: protein localization to microtubule cytoskeleton namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0044380 ! protein localization to cytoskeleton created_by: midori creation_date: 2012-04-11T01:19:35Z [Term] id: GO:0072699 name: protein localization to cortical microtubule cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to cortical microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072698 ! protein localization to microtubule cytoskeleton created_by: midori creation_date: 2012-04-11T01:23:36Z [Term] id: GO:0072700 name: response to bismuth namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [CHEBI:33301, GOC:mah] synonym: "response to bismuth ion" EXACT [] is_a: GO:0010035 ! response to inorganic substance created_by: midori creation_date: 2012-04-11T02:56:35Z [Term] id: GO:0072701 name: cellular response to bismuth namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [CHEBI:33301, GOC:mah] synonym: "cellular response to bismuth ion" EXACT [] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072700 ! response to bismuth created_by: midori creation_date: 2012-04-11T02:56:42Z [Term] id: GO:0072702 name: response to methyl methanesulfonate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah] synonym: "response to MMS" EXACT [CHEBI:25255, GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2012-04-11T03:04:12Z [Term] id: GO:0072703 name: cellular response to methyl methanesulfonate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah] synonym: "cellular response to MMS" EXACT [CHEBI:25255, GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0072702 ! response to methyl methanesulfonate is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-04-11T03:04:18Z [Term] id: GO:0072704 name: response to mercaptoethanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [CHEBI:41218, GOC:mah] synonym: "response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah] is_a: GO:0097305 ! response to alcohol created_by: midori creation_date: 2012-04-11T03:27:02Z [Term] id: GO:0072705 name: cellular response to mercaptoethanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [CHEBI:41218, GOC:mah] synonym: "cellular response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah] is_a: GO:0072704 ! response to mercaptoethanol is_a: GO:0097306 ! cellular response to alcohol created_by: midori creation_date: 2012-04-11T03:27:40Z [Term] id: GO:0072706 name: response to sodium dodecyl sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [CHEBI:8984, GOC:mah] synonym: "response to SDS" EXACT [CHEBI:8984, GOC:mah] is_a: GO:1902074 ! response to salt created_by: midori creation_date: 2012-04-11T03:35:07Z [Term] id: GO:0072707 name: cellular response to sodium dodecyl sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [CHEBI:8984, GOC:mah] synonym: "cellular response to SDS" EXACT [CHEBI:8984, GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0072706 ! response to sodium dodecyl sulfate is_a: GO:1902075 ! cellular response to salt created_by: midori creation_date: 2012-04-11T03:35:15Z [Term] id: GO:0072708 name: response to sorbitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah] synonym: "response to glucitol" EXACT [CHEBI:30911, GOC:mah] is_a: GO:0009743 ! response to carbohydrate created_by: midori creation_date: 2012-04-11T03:40:57Z [Term] id: GO:0072709 name: cellular response to sorbitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah] synonym: "cellular response to glucitol" EXACT [CHEBI:30911, GOC:mah] is_a: GO:0071322 ! cellular response to carbohydrate stimulus is_a: GO:0072708 ! response to sorbitol created_by: midori creation_date: 2012-04-11T03:41:03Z [Term] id: GO:0072710 name: response to hydroxyurea namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah] synonym: "response to HU" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901698 ! response to nitrogen compound created_by: midori creation_date: 2012-04-11T04:15:42Z [Term] id: GO:0072711 name: cellular response to hydroxyurea namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah] synonym: "cellular response to HU" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072710 ! response to hydroxyurea is_a: GO:1901699 ! cellular response to nitrogen compound created_by: midori creation_date: 2012-04-11T04:15:56Z [Term] id: GO:0072712 name: response to thiabendazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah] synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0060992 ! response to fungicide created_by: midori creation_date: 2012-04-11T04:23:56Z [Term] id: GO:0072713 name: cellular response to thiabendazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah] synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072712 ! response to thiabendazole is_a: GO:0097237 ! cellular response to toxic substance created_by: midori creation_date: 2012-04-11T04:24:19Z [Term] id: GO:0072714 name: response to selenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah] is_a: GO:0010035 ! response to inorganic substance created_by: midori creation_date: 2012-04-19T02:46:28Z [Term] id: GO:0072715 name: cellular response to selenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072714 ! response to selenite ion created_by: midori creation_date: 2012-04-19T02:47:50Z [Term] id: GO:0072716 name: response to actinomycin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [CHEBI:27666, GOC:mah] is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: midori creation_date: 2012-04-26T02:06:40Z [Term] id: GO:0072717 name: cellular response to actinomycin D namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [CHEBI:27666, GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0072716 ! response to actinomycin D is_a: GO:1901653 ! cellular response to peptide created_by: midori creation_date: 2012-04-26T02:06:55Z [Term] id: GO:0072718 name: response to cisplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [CHEBI:27899, GOC:mah] is_a: GO:0009636 ! response to toxic substance is_a: GO:0097327 ! response to antineoplastic agent created_by: midori creation_date: 2012-04-30T11:31:05Z [Term] id: GO:0072719 name: cellular response to cisplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [CHEBI:27899, GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0072718 ! response to cisplatin is_a: GO:0097237 ! cellular response to toxic substance created_by: midori creation_date: 2012-04-30T11:31:12Z [Term] id: GO:0072720 name: response to dithiothreitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [CHEBI:18320, GOC:mah] synonym: "response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah] synonym: "response to DTT" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2012-05-09T11:08:58Z [Term] id: GO:0072721 name: cellular response to dithiothreitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [CHEBI:18320, GOC:mah] synonym: "cellular response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah] synonym: "cellular response to DTT" EXACT [GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0072720 ! response to dithiothreitol is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-05-09T11:09:08Z [Term] id: GO:0072722 name: response to amitrole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [CHEBI:40036, GOC:mah] synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah] is_a: GO:0009635 ! response to herbicide is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound created_by: midori creation_date: 2012-05-31T10:51:45Z [Term] id: GO:0072723 name: cellular response to amitrole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [CHEBI:40036, GOC:mah] synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072722 ! response to amitrole is_a: GO:0097237 ! cellular response to toxic substance created_by: midori creation_date: 2012-05-31T10:51:52Z [Term] id: GO:0072724 name: response to 4-nitroquinoline N-oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [CHEBI:16907, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2012-05-31T11:00:37Z [Term] id: GO:0072725 name: cellular response to 4-nitroquinoline N-oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [CHEBI:16907, GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072724 ! response to 4-nitroquinoline N-oxide is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-05-31T11:00:42Z [Term] id: GO:0072726 name: response to CCCP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [CHEBI:3259, GOC:mah] synonym: "response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound created_by: midori creation_date: 2012-05-31T11:16:38Z [Term] id: GO:0072727 name: cellular response to CCCP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [CHEBI:3259, GOC:mah] synonym: "cellular response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072726 ! response to CCCP created_by: midori creation_date: 2012-05-31T11:16:43Z [Term] id: GO:0072728 name: response to Gentian violet namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [CHEBI:198346, GOC:mah] synonym: "response to crystal violet" EXACT [GOC:mah] synonym: "response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah] is_a: GO:0010033 ! response to organic substance created_by: midori creation_date: 2012-05-31T11:23:25Z [Term] id: GO:0072729 name: cellular response to Gentian violet namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [CHEBI:198346, GOC:mah] synonym: "cellular response to crystal violet" EXACT [GOC:mah] synonym: "cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0072728 ! response to Gentian violet created_by: midori creation_date: 2012-05-31T11:23:40Z [Term] id: GO:0072730 name: response to papulacandin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [CHEBI:569624, GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: midori creation_date: 2012-05-31T11:30:32Z [Term] id: GO:0072731 name: cellular response to papulacandin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [CHEBI:569624, GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0072730 ! response to papulacandin B is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-05-31T11:30:39Z [Term] id: GO:0072732 name: cellular response to calcium ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions." [GOC:mah] synonym: "cellular response to calcium starvation" EXACT [GOC:mah] is_a: GO:0009267 ! cellular response to starvation created_by: midori creation_date: 2012-07-06T02:42:26Z [Term] id: GO:0072733 name: response to staurosporine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [CHEBI:15738, GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:0060359 ! response to ammonium ion created_by: midori creation_date: 2012-07-17T10:32:28Z [Term] id: GO:0072734 name: cellular response to staurosporine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [CHEBI:15738, GOC:mah] is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0072733 ! response to staurosporine created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072735 name: response to t-BOOH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [CHEBI:365419, GOC:mah] synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419] synonym: "response to tert-butyl hydroperoxide" EXACT [GOC:mah] is_a: GO:0033195 ! response to alkyl hydroperoxide is_a: GO:0046677 ! response to antibiotic created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072736 name: cellular response to t-BOOH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [CHEBI:365419, GOC:mah] synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419] synonym: "cellular response to tert-butyl hydroperoxide" EXACT [GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071448 ! cellular response to alkyl hydroperoxide is_a: GO:0072735 ! response to t-BOOH created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072737 name: response to diamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [CHEBI:48958, GOC:mah] synonym: "response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] is_a: GO:1901698 ! response to nitrogen compound created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072738 name: cellular response to diamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [CHEBI:48958, GOC:mah] synonym: "cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] is_a: GO:0072737 ! response to diamide is_a: GO:1901699 ! cellular response to nitrogen compound created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072739 name: response to anisomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [CHEBI:338412, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072740 name: cellular response to anisomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [CHEBI:338412, GOC:mah] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072739 ! response to anisomycin created_by: midori creation_date: 2012-07-17T10:33:00Z [Term] id: GO:0072741 name: protein localization to cell division site namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689] synonym: "protein localisation to cell division site" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization created_by: midori creation_date: 2012-08-16T11:51:48Z [Term] id: GO:0072742 name: SAGA complex localization to transcription regulatory region namespace: biological_process def: "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene." [GOC:mah] synonym: "SAGA complex localization to promoter" EXACT [GOC:mah] synonym: "SAGA complex recruitment" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization created_by: midori creation_date: 2012-08-24T10:36:03Z [Term] id: GO:0072743 name: cellular response to erythromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901323 ! response to erythromycin is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-08-31T12:24:52Z [Term] id: GO:0072744 name: cellular response to trichodermin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901324 ! response to trichodermin created_by: midori creation_date: 2012-08-31T12:29:38Z [Term] id: GO:0072745 name: cellular response to antimycin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901325 ! response to antimycin A is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-08-31T12:31:08Z [Term] id: GO:0072746 name: cellular response to tetracycline namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901326 ! response to tetracycline is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2012-08-31T12:32:43Z [Term] id: GO:0072747 name: cellular response to chloramphenicol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901322 ! response to chloramphenicol is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-08-31T12:33:30Z [Term] id: GO:0072748 name: cellular response to tacrolimus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:mah] synonym: "cellular response to FK506" EXACT [CHEBI:61057] synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057] is_a: GO:0035690 ! cellular response to drug is_a: GO:1901327 ! response to tacrolimus created_by: midori creation_date: 2012-08-31T12:34:32Z [Term] id: GO:0072749 name: cellular response to cytochalasin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0036146 ! cellular response to mycotoxin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901328 ! response to cytochalasin B is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-08-31T12:37:15Z [Term] id: GO:0072750 name: cellular response to leptomycin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901344 ! response to leptomycin B created_by: midori creation_date: 2012-09-10T14:07:32Z [Term] id: GO:0072751 name: cellular response to L-thialysine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:mah] synonym: "cellular response to thialysine" BROAD [GOC:mah] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901345 ! response to L-thialysine created_by: midori creation_date: 2012-09-10T14:12:21Z [Term] id: GO:0072752 name: cellular response to rapamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901355 ! response to rapamycin is_a: GO:1901655 ! cellular response to ketone created_by: midori creation_date: 2012-09-14T11:13:34Z [Term] id: GO:0072753 name: cellular response to glutathione namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:mah] is_a: GO:1901370 ! response to glutathione is_a: GO:1901653 ! cellular response to peptide created_by: midori creation_date: 2012-09-25T12:27:39Z [Term] id: GO:0072754 name: cellular response to purvalanol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:mah] is_a: GO:0071415 ! cellular response to purine-containing compound is_a: GO:1901560 ! response to purvalanol A created_by: midori creation_date: 2012-11-07T12:05:57Z [Term] id: GO:0072755 name: cellular response to benomyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901561 ! response to benomyl is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-07T12:06:58Z [Term] id: GO:0072756 name: cellular response to paraquat namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901562 ! response to paraquat created_by: midori creation_date: 2012-11-07T12:08:59Z [Term] id: GO:0072757 name: cellular response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah] synonym: "cellular response to CPT" EXACT [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901563 ! response to camptothecin created_by: midori creation_date: 2012-11-07T12:12:35Z [Term] id: GO:0072758 name: response to topoisomerase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah] is_a: GO:0042221 ! response to chemical created_by: midori creation_date: 2012-11-09T11:34:51Z [Term] id: GO:0072759 name: cellular response to topoisomerase inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0072758 ! response to topoisomerase inhibitor created_by: midori creation_date: 2012-11-09T11:38:08Z [Term] id: GO:0072760 name: cellular response to GW 7647 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901593 ! response to GW 7647 is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-09T11:46:28Z [Term] id: GO:0072761 name: cellular response to capsazepine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901594 ! response to capsazepine is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-09T11:47:53Z [Term] id: GO:0072762 name: cellular response to carbendazim namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901597 ! response to carbendazim is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-09T11:48:11Z [Term] id: GO:0072763 name: cellular response to hesperadin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071418 ! cellular response to amine stimulus is_a: GO:1901595 ! response to hesperadin is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-09T11:50:58Z [Term] id: GO:0072764 name: cellular response to reversine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071415 ! cellular response to purine-containing compound is_a: GO:1901596 ! response to reversine is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: midori creation_date: 2012-11-09T11:52:22Z [Term] id: GO:0072765 name: centromere localization namespace: biological_process def: "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of kinetochore localization" EXACT [GOC:mah] synonym: "kinetochore localisation" EXACT [GOC:mah] synonym: "kinetochore localization" EXACT [] is_a: GO:0034629 ! cellular protein-containing complex localization is_a: GO:0051640 ! organelle localization created_by: midori creation_date: 2012-11-21T13:30:53Z [Term] id: GO:0072766 name: centromere clustering at the mitotic nuclear envelope namespace: biological_process def: "A cellular localization process in which kinetochores/centromeres are coupled together at the nuclear periphery. This process is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. In fission yeast this occurs at a location near the old mitotic spindle pole body." [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349] synonym: "centromere clustering at the nuclear periphery" EXACT [] synonym: "centromere-SPB clustering" RELATED [GOC:vw, PMID:18158900] synonym: "kinetochore clustering at SPB" RELATED [GOC:mah] synonym: "kinetochore clustering at spindle pole body" RELATED [] synonym: "kinetochore clustering at the old mitotic spindle pole body" RELATED [] synonym: "kinetochore localization at spindle pole body" RELATED [GOC:pr] synonym: "rabl configuration" RELATED [PMID:17881496] is_a: GO:0098653 ! centromere clustering relationship: part_of GO:0000278 ! mitotic cell cycle created_by: midori creation_date: 2012-11-21T13:32:22Z [Term] id: GO:0075000 name: response to host osmotic environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response of symbiont to host osmotic environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075001 name: adhesion of symbiont infection structure to host namespace: biological_process def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT [] synonym: "attachment of symbiont infection structure to host" EXACT [] is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0075002 name: adhesion of symbiont germination tube to host namespace: biological_process def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075003 name: adhesion of symbiont appressorium to host namespace: biological_process def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075004 name: adhesion of symbiont spore to host namespace: biological_process def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT [] is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0075005 name: spore germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0009847 ! spore germination is_a: GO:0044132 ! development of symbiont on or near host is_a: GO:0051701 ! interaction with host [Term] id: GO:0075006 name: modulation of spore germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:1904359 ! regulation of spore germination relationship: regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075007 name: positive regulation of spore germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075006 ! modulation of spore germination on or near host is_a: GO:1904361 ! positive regulation of spore germination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075005 ! spore germination on or near host relationship: positively_regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075008 name: negative regulation of spore germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075006 ! modulation of spore germination on or near host is_a: GO:1904360 ! negative regulation of spore germination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075005 ! spore germination on or near host relationship: negatively_regulates GO:0075005 ! spore germination on or near host [Term] id: GO:0075009 name: germ tube formation on or near host namespace: biological_process def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044132 ! development of symbiont on or near host relationship: part_of GO:0075005 ! spore germination on or near host [Term] id: GO:0075010 name: modulation of germ tube formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075006 ! modulation of spore germination on or near host relationship: regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075011 name: positive regulation of germ tube formation on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075007 ! positive regulation of spore germination on or near host is_a: GO:0075010 ! modulation of germ tube formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075009 ! germ tube formation on or near host relationship: positively_regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075012 name: negative regulation of germ tube formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075008 ! negative regulation of spore germination on or near host is_a: GO:0075010 ! modulation of germ tube formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075009 ! germ tube formation on or near host relationship: negatively_regulates GO:0075009 ! germ tube formation on or near host [Term] id: GO:0075013 name: obsolete growth or development of symbiont on or near host phyllosphere namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host phyllosphere ; GO:0044135' and 'development of symbiont on or near host phyllosphere ; GO:0044134'. synonym: "growth or development of symbiont on or near host phyllosphere" EXACT [] is_obsolete: true consider: GO:0044134 consider: GO:0044135 [Term] id: GO:0075014 name: obsolete growth or development of symbiont on or near host rhizosphere namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host rhizosphere ; GO:0044137' and 'development of symbiont on or near host rhizosphere ; GO:0044136'. synonym: "growth or development of symbiont on or near host rhizosphere" EXACT [] is_obsolete: true consider: GO:0044136 consider: GO:0044137 [Term] id: GO:0075015 name: formation of infection structure on or near host namespace: biological_process def: "The process in which a symbiont structure that serves to infect the host is formed on or near its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "formation by symbiont of infection structure on or near host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0075016 name: appressorium formation on or near host namespace: biological_process def: "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium formation for entry into host, on or near host" EXACT [] synonym: "formation of an appressorium by symbiont on or near host" EXACT [] is_a: GO:0044134 ! development of symbiont on or near host phyllosphere is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075017 name: regulation of appressorium formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075016 ! appressorium formation on or near host relationship: regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075018 name: positive regulation of appressorium formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075017 ! regulation of appressorium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075016 ! appressorium formation on or near host relationship: positively_regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075019 name: negative regulation of appressorium formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075017 ! regulation of appressorium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075016 ! appressorium formation on or near host relationship: negatively_regulates GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075020 name: calcium or calmodulin-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT [] synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075021 name: cAMP-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "cyclic AMP mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075022 name: ethylene-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075023 name: MAPK-mediated regulation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075024 name: phospholipase C-mediated activation of appressorium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075018 ! positive regulation of appressorium formation on or near host [Term] id: GO:0075025 name: initiation of appressorium on or near host namespace: biological_process def: "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium initiation on or near host" EXACT [] synonym: "initiation of appressorium by symbiont on or near host" EXACT [] synonym: "initiation of symbiont appressorium on or near host" EXACT [] is_a: GO:0044111 ! development involved in symbiotic interaction relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075026 name: regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075017 ! regulation of appressorium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075025 ! initiation of appressorium on or near host relationship: regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075027 name: positive regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host is_a: GO:0075026 ! regulation of appressorium initiation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075025 ! initiation of appressorium on or near host relationship: positively_regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075028 name: negative regulation of appressorium initiation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of initiation of appressorium on or near host" EXACT [] is_a: GO:0075019 ! negative regulation of appressorium formation on or near host is_a: GO:0075026 ! regulation of appressorium initiation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075025 ! initiation of appressorium on or near host relationship: negatively_regulates GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075029 name: formation of symbiont germ tube hook structure on or near host namespace: biological_process def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT [] synonym: "symbiont germ tube hook structure formation on or near host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075025 ! initiation of appressorium on or near host [Term] id: GO:0075030 name: modulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] is_a: GO:0075026 ! regulation of appressorium initiation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host relationship: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075031 name: positive regulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] is_a: GO:0075027 ! positive regulation of appressorium initiation on or near host is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host relationship: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075032 name: negative regulation of symbiont germ tube hook structure formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] is_a: GO:0075028 ! negative regulation of appressorium initiation on or near host is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host relationship: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host [Term] id: GO:0075033 name: septum formation involved in appressorium formation on or near host namespace: biological_process def: "The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring on or near the exterior of its host organism during appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "septum formation during appressorium formation on or near host" RELATED [GOC:tb] is_a: GO:0044132 ! development of symbiont on or near host relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075034 name: nuclear division involved in appressorium formation on or near host namespace: biological_process def: "The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "nuclear division during appressorium formation on or near host" RELATED [GOC:dph] is_a: GO:0000280 ! nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0075016 ! appressorium formation on or near host relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075035 name: maturation of appressorium on or near host namespace: biological_process def: "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "appressorium maturation on or near host" EXACT [] synonym: "maturation of symbiont appressorium on or near host" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host relationship: part_of GO:0075016 ! appressorium formation on or near host [Term] id: GO:0075036 name: regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of maturation of appressorium on or near host" EXACT [] is_a: GO:0075017 ! regulation of appressorium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075035 ! maturation of appressorium on or near host relationship: regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075037 name: positive regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation maturation of appressorium on or near host" EXACT [] is_a: GO:0075018 ! positive regulation of appressorium formation on or near host is_a: GO:0075036 ! regulation of appressorium maturation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075035 ! maturation of appressorium on or near host relationship: positively_regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075038 name: negative regulation of appressorium maturation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation in, near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of maturation of appressorium on or near host" EXACT [] is_a: GO:0075019 ! negative regulation of appressorium formation on or near host is_a: GO:0075036 ! regulation of appressorium maturation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075035 ! maturation of appressorium on or near host relationship: negatively_regulates GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075039 name: establishment of turgor in appressorium namespace: biological_process def: "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT [] synonym: "formation of turgor in appressorium" EXACT [] synonym: "generation of turgor in appressorium" EXACT [] is_a: GO:0044115 ! development of symbiont involved in interaction with host relationship: part_of GO:0075035 ! maturation of appressorium on or near host [Term] id: GO:0075040 name: regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of turgor formation in appressorium" RELATED [] is_a: GO:0075036 ! regulation of appressorium maturation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075039 ! establishment of turgor in appressorium relationship: regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075041 name: positive regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075037 ! positive regulation of appressorium maturation on or near host is_a: GO:0075040 ! regulation of establishment of turgor in appressorium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075039 ! establishment of turgor in appressorium relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075042 name: negative regulation of establishment of turgor in appressorium namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075038 ! negative regulation of appressorium maturation on or near host is_a: GO:0075040 ! regulation of establishment of turgor in appressorium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075039 ! establishment of turgor in appressorium relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium [Term] id: GO:0075043 name: maintenance of turgor in appressorium by melanization namespace: biological_process def: "The process in which melanin is produced in the appressorium of the symbiont on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "melanization of appressorium to maintain turgor pressure" EXACT [] is_a: GO:0042438 ! melanin biosynthetic process is_a: GO:0075040 ! regulation of establishment of turgor in appressorium [Term] id: GO:0075044 name: positive regulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism increases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "autophagy of host cells during interaction with symbiont" RELATED [GOC:dph] synonym: "autophagy of host cells involved in interaction with symbiont" RELATED [] synonym: "positive regulation by symbiont of host autophagotic process" RELATED [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0075071 ! modulation by symbiont of host autophagy intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0075045 name: regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:0044127 ! regulation of development of symbiont in host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host relationship: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075046 name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044129 ! positive regulation of development of symbiont in host is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host relationship: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075047 name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044131 ! negative regulation of development of symbiont in host is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host relationship: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host [Term] id: GO:0075048 name: cell wall strengthening in symbiont involved in entry into host namespace: biological_process def: "A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "cell wall strengthening in symbiont during entry into host" RELATED [GOC:tb] synonym: "cell wall thickening in symbiont during entry into host" RELATED [] synonym: "symbiont cell wall strengthening during entry into host" RELATED [] is_a: GO:0052386 ! cell wall thickening relationship: part_of GO:0044409 ! entry into host [Term] id: GO:0075049 name: obsolete modulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for the obsoletion is that there is no evidence that those processes exist. synonym: "modulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0075050 name: obsolete positive regulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for the obsoletion is that there is no evidence that those processes exist. synonym: "positive regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0075051 name: obsolete negative regulation of symbiont cell wall strengthening involved in entry into host namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for the obsoletion is that there is no evidence that those processes exist. synonym: "negative regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0075052 name: entry into host cell via penetration peg namespace: biological_process def: "Penetration of a symbiont into the body, tissues, or cells of a host organism via a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "entry into host via a specialized structure during symbiotic interaction" EXACT [] synonym: "penetration into host via a specialized structure" EXACT [GOC:vw] synonym: "penetration into host via a specialized structure during symbiotic interaction" EXACT [GOC:vw] is_a: GO:0044409 ! entry into host [Term] id: GO:0075053 name: formation of symbiont penetration peg for entry into host namespace: biological_process def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration peg formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host cell via penetration peg [Term] id: GO:0075054 name: modulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075055 name: positive regulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host relationship: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075056 name: negative regulation of symbiont penetration peg formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host relationship: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075057 name: initiation of symbiont penetration peg namespace: biological_process def: "The process in which a relatively unspecialized cell of the symbiont starts to acquire the characteristics of a mature penetration peg to penetrate into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration peg initiation" EXACT [] is_a: GO:0044111 ! development involved in symbiotic interaction relationship: part_of GO:0075053 ! formation of symbiont penetration peg for entry into host [Term] id: GO:0075058 name: modulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of penetration peg initiation, the process in which a relatively unspecialized cell start to acquire the characteristics of a mature penetration peg when the symbiont penetrates its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host relationship: regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075059 name: positive regulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075055 ! positive regulation of symbiont penetration peg formation for entry into host is_a: GO:0075058 ! modulation of symbiont penetration peg initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075057 ! initiation of symbiont penetration peg relationship: positively_regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075060 name: negative regulation of symbiont penetration peg initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg initiation, the process in which a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075056 ! negative regulation of symbiont penetration peg formation for entry into host is_a: GO:0075058 ! modulation of symbiont penetration peg initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg relationship: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg [Term] id: GO:0075061 name: invasive hyphal growth namespace: biological_process def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of invasive growth within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of symbiont invasive hypha in host" EXACT [] synonym: "formation of symbiont invasive hypha within host" EXACT [] synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] synonym: "symbiont invasive hypha formation within host" EXACT [] is_a: GO:0030448 ! hyphal growth is_a: GO:0044114 ! development of symbiont in host [Term] id: GO:0075062 name: regulation of invasive hypha growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "regulation of symbiont invasive hypha formation in host" EXACT [] synonym: "regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0010570 ! regulation of filamentous growth is_a: GO:0044127 ! regulation of development of symbiont in host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075061 ! invasive hyphal growth relationship: regulates GO:0075061 ! invasive hyphal growth [Term] id: GO:0075063 name: positive regulation of invasive hypha growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "positive regulation of symbiont invasive hypha formation in host" EXACT [] synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044129 ! positive regulation of development of symbiont in host is_a: GO:0075062 ! regulation of invasive hypha growth is_a: GO:0090033 ! positive regulation of filamentous growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075061 ! invasive hyphal growth relationship: positively_regulates GO:0075061 ! invasive hyphal growth [Term] id: GO:0075064 name: negative regulation invasive hypha growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "negative regulation of symbiont invasive hypha formation in host" EXACT [] synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT [] is_a: GO:0044131 ! negative regulation of development of symbiont in host is_a: GO:0060258 ! negative regulation of filamentous growth is_a: GO:0075062 ! regulation of invasive hypha growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075061 ! invasive hyphal growth relationship: negatively_regulates GO:0075061 ! invasive hyphal growth [Term] id: GO:0075065 name: obsolete growth or development of symbiont in host cell namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host cell ; GO:0044118' and 'growth of symbiont in host cell ; GO:0044119'. synonym: "growth or development of symbiont in host cell" EXACT [] is_obsolete: true consider: GO:0044118 consider: GO:0044119 [Term] id: GO:0075066 name: obsolete growth or development of symbiont in host organelle namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host organelle ; GO:0044120' and 'growth of symbiont in host organelle ; GO:0044121'. synonym: "growth or development of symbiont in host organelle" EXACT [] is_obsolete: true consider: GO:0044120 consider: GO:0044121 [Term] id: GO:0075067 name: obsolete growth or development of symbiont in host intercellular space namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth of symbiont in host intercellular space ; GO:0044125'. synonym: "growth or development of symbiont in host intercellular space" EXACT [] is_obsolete: true consider: GO:0044114 consider: GO:0044117 [Term] id: GO:0075068 name: obsolete growth or development of symbiont in host vascular tissue namespace: biological_process def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'. synonym: "growth or development of symbiont in host vascular tissue" EXACT [] is_obsolete: true consider: GO:0044114 consider: GO:0044117 [Term] id: GO:0075069 name: adhesion of symbiont infection cushion to host namespace: biological_process def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075070 name: adhesion of symbiont hyphopodium to host namespace: biological_process def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075071 name: modulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph] synonym: "autophagy involved in symbiotic interaction" RELATED [] synonym: "modulation by symbiont of host autophagic process" RELATED [] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0006914 ! autophagy [Term] id: GO:0075072 name: obsolete autophagy of symbiont cells involved in interaction with host namespace: biological_process def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. synonym: "autophagy of symbiont cells during interaction with host" RELATED [GOC:dph] is_obsolete: true [Term] id: GO:0075073 name: obsolete autophagy of symbiont cells on or near host surface namespace: biological_process def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. is_obsolete: true [Term] id: GO:0075074 name: obsolete spore autophagy involved in appressorium formation on or near host namespace: biological_process def: "OBSOLETE. The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. synonym: "autophagy of spores during appressorium formation on or near host" EXACT [] synonym: "spore autophagy during appressorium formation on or near host" RELATED [GOC:tb] is_obsolete: true [Term] id: GO:0075075 name: modulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase activity ; GO:0075106". is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0052422 ! modulation by host of symbiont catalytic activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075076 name: positive regulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0043947 ! positive regulation by host of symbiont catalytic activity is_a: GO:0045762 ! positive regulation of adenylate cyclase activity is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: positively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075077 name: negative regulation by host of symbiont adenylate cyclase activity namespace: biological_process def: "Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host adenylate cyclase activity ; GO:0075108". is_a: GO:0007194 ! negative regulation of adenylate cyclase activity is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: negatively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075078 name: obsolete modulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075079 name: obsolete positive regulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075080 name: obsolete negative regulation by host of symbiont receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075081 name: obsolete modulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075082 name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075083 name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075084 name: obsolete modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] is_obsolete: true [Term] id: GO:0075085 name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT [] synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075086 name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] is_obsolete: true [Term] id: GO:0075087 name: obsolete modulation by host of symbiont G protein-coupled receptor signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "modulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075088 name: obsolete positive regulation by host of symbiont G protein-coupled receptor signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "positive regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075089 name: obsolete negative regulation by host of symbiont G protein-coupled receptor signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075090 name: obsolete modulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075091 name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075092 name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075093 name: obsolete modulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075094 name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075095 name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075096 name: obsolete modulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075097 name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075098 name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075099 name: obsolete modulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075100 name: obsolete positive regulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075101 name: obsolete negative regulation by host of symbiont protein kinase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075102 name: obsolete negative regulation by host of symbiont MAP kinase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075103 name: obsolete modulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075104 name: obsolete positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075105 name: obsolete negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075106 name: modulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont adenylate cyclase activity ; GO:0075075". synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED [] is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0052148 ! modulation by symbiont of host catalytic activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075107 name: positive regulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont adenylate cyclase activity ; GO:0075076". synonym: "positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "positive regulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "positive regulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "positive regulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] is_a: GO:0043948 ! induction by symbiont of host catalytic activity is_a: GO:0045762 ! positive regulation of adenylate cyclase activity is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: positively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075108 name: negative regulation by symbiont of host adenylate cyclase activity namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase activity ; GO:0075077". synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED [] is_a: GO:0007194 ! negative regulation of adenylate cyclase activity is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity intersection_of: GO:0052055 ! modulation by symbiont of host molecular function intersection_of: negatively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0075109 name: modulation by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075110 name: induction by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". synonym: "positive regulation by symbiont of host receptor-mediated signal transduction" EXACT [] is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075111 name: suppression by symbiont of host receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080". synonym: "negative regulation by symbiont of host receptor-mediated signal transduction" EXACT [] is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075112 name: modulation by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081". is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction [Term] id: GO:0075113 name: induction by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". synonym: "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT [] is_a: GO:0075110 ! induction by symbiont of host receptor-mediated signal transduction is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075114 name: suppression by symbiont of host transmembrane receptor-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083". synonym: "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT [] is_a: GO:0075111 ! suppression by symbiont of host receptor-mediated signal transduction is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075115 name: obsolete modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that this process exists. synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] is_obsolete: true [Term] id: GO:0075116 name: obsolete induction by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that this process exists. synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] is_obsolete: true [Term] id: GO:0075117 name: obsolete suppression by symbiont of host transmembrane receptor-mediated cAMP signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that this process exists. synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] is_obsolete: true [Term] id: GO:0075118 name: modulation by symbiont of host G protein-coupled receptor signal transduction namespace: biological_process alt_id: GO:0075121 alt_id: GO:0075124 alt_id: GO:0075127 def: "Any process in which the symbiont modulates the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075087". synonym: "modulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] synonym: "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] synonym: "modulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] synonym: "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction [Term] id: GO:0075119 name: induction by symbiont of host G protein-coupled receptor signal transduction namespace: biological_process alt_id: GO:0075122 alt_id: GO:0075125 alt_id: GO:0075128 def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G protein-coupled receptor signal transduction ; GO:0075088". synonym: "positive regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [] synonym: "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0075113 ! induction by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075118 ! modulation by symbiont of host G protein-coupled receptor signal transduction [Term] id: GO:0075120 name: suppression by symbiont of host G protein-coupled receptor signal transduction namespace: biological_process alt_id: GO:0075123 alt_id: GO:0075126 alt_id: GO:0075129 def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075089". synonym: "negative regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [] synonym: "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0075114 ! suppression by symbiont of host transmembrane receptor-mediated signal transduction is_a: GO:0075118 ! modulation by symbiont of host G protein-coupled receptor signal transduction [Term] id: GO:0075130 name: modulation by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075131 name: induction by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100". synonym: "positive regulation by symbiont of host protein kinase-mediated signal transduction" EXACT [] is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0075132 name: suppression by symbiont of host protein kinase-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101". synonym: "negative regulation by symbiont of host protein kinase-mediated signal transduction" EXACT [] is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction [Term] id: GO:0075133 name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075134 name: induction by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104". synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] synonym: "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction [Term] id: GO:0075135 name: suppression by symbiont of host calcium or calmodulin-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] synonym: "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction" EXACT [] is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction [Term] id: GO:0075136 name: response to host namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host" RELATED [] is_a: GO:0051701 ! interaction with host is_a: GO:0051707 ! response to other organism [Term] id: GO:0075137 name: response to host redox environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host redox environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075138 name: response to host oxygen tension environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host oxygen tension environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075139 name: response to host iron concentration namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host iron concentration" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075140 name: response to host defense molecules namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting host defense molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "response of symbiont to host defense molecules" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075141 name: maintenance of symbiont tolerance to host environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075136 ! response to host [Term] id: GO:0075142 name: maintenance of symbiont tolerance to host oxygen tension environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against oxygen tension environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075138 ! response to host oxygen tension environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075143 name: maintenance of symbiont tolerance to host redox environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against redox environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075137 ! response to host redox environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075144 name: maintenance of symbiont tolerance to host iron concentration namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against iron concentration environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075139 ! response to host iron concentration is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075145 name: maintenance of symbiont tolerance to host defense molecules namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against defense molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075140 ! response to host defense molecules is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075146 name: maintenance of symbiont tolerance to host osmotic environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against osmotic environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075000 ! response to host osmotic environment is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment [Term] id: GO:0075147 name: obsolete regulation of signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075148 name: obsolete positive regulation of signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075149 name: obsolete negative regulation of signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075150 name: obsolete regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075151 name: obsolete positive regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075152 name: obsolete negative regulation of receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075153 name: obsolete regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075154 name: obsolete positive regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true [Term] id: GO:0075155 name: obsolete negative regulation of transmembrane receptor-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075156 name: obsolete regulation of G protein-coupled receptor signaling pathway in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075157 name: obsolete positive regulation of G protein-coupled receptor signaling pathway in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075158 name: obsolete negative regulation of G protein-coupled receptor signaling pathway in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075159 name: obsolete regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075160 name: obsolete positive regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075161 name: obsolete negative regulation of G-protein alpha subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075162 name: obsolete regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075163 name: obsolete positive regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075164 name: obsolete negative regulation of G-protein beta subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075165 name: obsolete regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075166 name: obsolete positive regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075167 name: obsolete negative regulation of G-protein gamma subunit-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075168 name: obsolete regulation of protein kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075169 name: obsolete positive regulation of symbiont protein kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true [Term] id: GO:0075170 name: obsolete negative regulation of protein kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075171 name: obsolete regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075172 name: obsolete positive regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075173 name: obsolete negative regulation of MAP kinase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075174 name: obsolete regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075175 name: obsolete positive regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075176 name: obsolete negative regulation of cAMP-mediated signaling in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT [] synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT [] synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075177 name: obsolete regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075178 name: obsolete positive regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075179 name: obsolete negative regulation of calcium or calmodulin-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075180 name: regulation of transcription in response to host namespace: biological_process def: "Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. synonym: "regulation of symbiont transcription in response to host" EXACT [] is_a: GO:0075136 ! response to host is_a: GO:2001141 ! regulation of RNA biosynthetic process [Term] id: GO:0075181 name: positive regulation of symbiont transcription in response to host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0075180 ! regulation of transcription in response to host [Term] id: GO:0075182 name: negative regulation of symbiont transcription in response to host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0075180 ! regulation of transcription in response to host [Term] id: GO:0075183 name: infection cushion formation on or near host namespace: biological_process def: "The process in which an organized mass of hyphae is formed on or near the host organism, and numerous infective hyphae develop from the hyphae mass. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075184 name: regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075183 ! infection cushion formation on or near host relationship: regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075185 name: positive regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075184 ! regulation of infection cushion formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075183 ! infection cushion formation on or near host relationship: positively_regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075186 name: negative regulation of infection cushion formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0075184 ! regulation of infection cushion formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075183 ! infection cushion formation on or near host relationship: negatively_regulates GO:0075183 ! infection cushion formation on or near host [Term] id: GO:0075187 name: hyphopodium formation on or near host namespace: biological_process def: "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075188 name: regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075187 ! hyphopodium formation on or near host relationship: regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075189 name: positive regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075188 ! regulation of hyphopodium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075187 ! hyphopodium formation on or near host relationship: positively_regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075190 name: negative regulation of hyphopodium formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075188 ! regulation of hyphopodium formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075187 ! hyphopodium formation on or near host relationship: negatively_regulates GO:0075187 ! hyphopodium formation on or near host [Term] id: GO:0075191 name: obsolete autophagy of host cells on or near symbiont surface namespace: biological_process def: "OBSOLETE. The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. is_obsolete: true [Term] id: GO:0075192 name: haustorium mother cell formation on or near host namespace: biological_process def: "The process in which a symbiont cell is formed on or near its host organism, via separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075015 ! formation of infection structure on or near host [Term] id: GO:0075193 name: regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044138 ! modulation of development of symbiont on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075192 ! haustorium mother cell formation on or near host relationship: regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075194 name: positive regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host relationship: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075195 name: negative regulation of haustorium mother cell formation on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host [Term] id: GO:0075196 name: adhesion of symbiont haustorium mother cell to host namespace: biological_process def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT [] is_a: GO:0075001 ! adhesion of symbiont infection structure to host [Term] id: GO:0075197 name: formation of symbiont haustorium neck for entry into host namespace: biological_process def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont haustorium neck formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host cell via penetration peg [Term] id: GO:0075198 name: modulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075199 name: positive regulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host relationship: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075200 name: negative regulation of symbiont haustorium neck formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host relationship: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host [Term] id: GO:0075201 name: formation of symbiont penetration hypha for entry into host namespace: biological_process def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "symbiont penetration hypha formation for entry into host" EXACT [] is_a: GO:0075015 ! formation of infection structure on or near host relationship: part_of GO:0075052 ! entry into host cell via penetration peg [Term] id: GO:0075202 name: modulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0052372 ! modulation by symbiont of entry into host relationship: regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075203 name: positive regulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host is_a: GO:0075294 ! positive regulation by symbiont of entry into host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host relationship: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075204 name: negative regulation of symbiont penetration hypha formation for entry into host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0052374 ! negative regulation by symbiont of entry into host is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host relationship: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host [Term] id: GO:0075205 name: obsolete modulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED [] synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT [] synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_obsolete: true [Term] id: GO:0075206 name: obsolete positive regulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_obsolete: true [Term] id: GO:0075207 name: obsolete negative regulation by host of symbiont cAMP-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT [] is_obsolete: true [Term] id: GO:0075208 name: modulation by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0043949 ! regulation of cAMP-mediated signaling is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway [Term] id: GO:0075209 name: induction by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". synonym: "positive regulation by symbiont of host cAMP-mediated signal transduction" EXACT [] synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075210 name: suppression by symbiont of host cAMP-mediated signal transduction namespace: biological_process def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207". synonym: "negative regulation by symbiont of host cAMP-mediated signal transduction" EXACT [] synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction [Term] id: GO:0075211 name: obsolete regulation of transmembrane receptor-mediated cAMP signaling in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075212 name: obsolete positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED [] is_obsolete: true [Term] id: GO:0075213 name: obsolete negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] is_obsolete: true [Term] id: GO:0075214 name: spore encystment on host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:kmv, GOC:pamgo_curators] is_a: GO:0022611 ! dormancy process is_a: GO:0044132 ! development of symbiont on or near host [Term] id: GO:0075215 name: modulation of spore encystment on host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044138 ! modulation of development of symbiont on or near host relationship: regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075216 name: positive regulation of spore encystment on host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075215 ! modulation of spore encystment on host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075214 ! spore encystment on host relationship: positively_regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075217 name: negative regulation of spore encystment on host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075215 ! modulation of spore encystment on host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075214 ! spore encystment on host relationship: negatively_regulates GO:0075214 ! spore encystment on host [Term] id: GO:0075218 name: zoospore encystment on host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075214 ! spore encystment on host [Term] id: GO:0075219 name: modulation of zoospore encystment on host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075215 ! modulation of spore encystment on host relationship: regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075220 name: positive regulation of zoospore encystment on host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075216 ! positive regulation of spore encystment on host is_a: GO:0075219 ! modulation of zoospore encystment on host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075218 ! zoospore encystment on host relationship: positively_regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075221 name: negative regulation of zoospore encystment on host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075217 ! negative regulation of spore encystment on host is_a: GO:0075219 ! modulation of zoospore encystment on host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075218 ! zoospore encystment on host relationship: negatively_regulates GO:0075218 ! zoospore encystment on host [Term] id: GO:0075222 name: sporangium germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth occurring on or near its host organism. A sporangium is a structure producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "direct germination on or near host" NARROW [] synonym: "germination of symbiont sporangium on or near host" EXACT [] synonym: "symbiont sporangium germination on or near host" EXACT [] is_a: GO:0043582 ! sporangium development is_a: GO:0044132 ! development of symbiont on or near host is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0075223 name: modulation of sporangium germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangium germination. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044138 ! modulation of development of symbiont on or near host is_a: GO:0075310 ! regulation of sporangium development relationship: regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075224 name: positive regulation of sporangium germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface is_a: GO:0075223 ! modulation of sporangium germination on or near host is_a: GO:0075311 ! positive regulation of sporangium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075222 ! sporangium germination on or near host relationship: positively_regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075225 name: negative regulation of sporangium germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface is_a: GO:0075223 ! modulation of sporangium germination on or near host is_a: GO:0075312 ! negative regulation of sporangium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075222 ! sporangium germination on or near host relationship: negatively_regulates GO:0075222 ! sporangium germination on or near host [Term] id: GO:0075226 name: encysted zoospore germination on or near host namespace: biological_process def: "The physiological, developmental and morphological changes that occur in the symbiont encysted zoospore, which is on or near its host organism and germinates by developing a germ tube that may penetrate the host directly or indirectly through an appresorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075005 ! spore germination on or near host [Term] id: GO:0075227 name: modulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075006 ! modulation of spore germination on or near host relationship: regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075228 name: positive regulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075007 ! positive regulation of spore germination on or near host is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075226 ! encysted zoospore germination on or near host relationship: positively_regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075229 name: negative regulation of encysted zoospore germination on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0075008 ! negative regulation of spore germination on or near host is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host relationship: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host [Term] id: GO:0075230 name: spore movement on or near host namespace: biological_process def: "Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052127 ! movement on or near host [Term] id: GO:0075231 name: modulation of spore movement on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism relationship: regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075232 name: positive regulation of spore movement on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0075231 ! modulation of spore movement on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075230 ! spore movement on or near host relationship: positively_regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075233 name: negative regulation of spore movement on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0075231 ! modulation of spore movement on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075230 ! spore movement on or near host relationship: negatively_regulates GO:0075230 ! spore movement on or near host [Term] id: GO:0075234 name: zoospore movement on or near host namespace: biological_process def: "Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "zoospore motility on or near host" EXACT [] is_a: GO:0075230 ! spore movement on or near host [Term] id: GO:0075235 name: modulation of zoospore movement on or near host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "regulation of zoospore motility on or near host" EXACT [] is_a: GO:0075231 ! modulation of spore movement on or near host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075234 ! zoospore movement on or near host relationship: regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075236 name: positive regulation of zoospore movement on or near host namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075232 ! positive regulation of spore movement on or near host is_a: GO:0075235 ! modulation of zoospore movement on or near host intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075234 ! zoospore movement on or near host relationship: positively_regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075237 name: negative regulation of zoospore movement on or near host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0075233 ! negative regulation of spore movement on or near host is_a: GO:0075235 ! modulation of zoospore movement on or near host intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075234 ! zoospore movement on or near host relationship: negatively_regulates GO:0075234 ! zoospore movement on or near host [Term] id: GO:0075238 name: maintenance of symbiont tolerance to host pH environment namespace: biological_process def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against pH environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is used to annotate gene products of the symbiont. is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment is_a: GO:0075293 ! response to host pH environment [Term] id: GO:0075239 name: zoospore formation namespace: biological_process def: "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0034300 ! sporangiospore formation [Term] id: GO:0075240 name: regulation of zoospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075286 ! regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075239 ! zoospore formation relationship: regulates GO:0075239 ! zoospore formation [Term] id: GO:0075241 name: positive regulation of zoospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075240 ! regulation of zoospore formation is_a: GO:0075287 ! positive regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075239 ! zoospore formation relationship: positively_regulates GO:0075239 ! zoospore formation [Term] id: GO:0075242 name: negative regulation of zoospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] is_a: GO:0075240 ! regulation of zoospore formation is_a: GO:0075288 ! negative regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075239 ! zoospore formation relationship: negatively_regulates GO:0075239 ! zoospore formation [Term] id: GO:0075243 name: oospore formation namespace: biological_process def: "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi." [GOC:pamgo_curators] is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075244 name: regulation of oospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075243 ! oospore formation relationship: regulates GO:0075243 ! oospore formation [Term] id: GO:0075245 name: positive regulation of oospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075244 ! regulation of oospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075243 ! oospore formation relationship: positively_regulates GO:0075243 ! oospore formation [Term] id: GO:0075246 name: negative regulation of oospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075244 ! regulation of oospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075243 ! oospore formation relationship: negatively_regulates GO:0075243 ! oospore formation [Term] id: GO:0075247 name: aeciospore formation namespace: biological_process def: "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075248 name: regulation of aeciospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075247 ! aeciospore formation relationship: regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075249 name: positive regulation of aeciospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075248 ! regulation of aeciospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075247 ! aeciospore formation relationship: positively_regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075250 name: negative regulation of aeciospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075248 ! regulation of aeciospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075247 ! aeciospore formation relationship: negatively_regulates GO:0075247 ! aeciospore formation [Term] id: GO:0075251 name: uredospore formation namespace: biological_process def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators] synonym: "urediniospore formation" EXACT [] synonym: "ureidospore formation" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075252 name: regulation of uredospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "regulation of ureidospore formation" EXACT [] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075251 ! uredospore formation relationship: regulates GO:0075251 ! uredospore formation [Term] id: GO:0075253 name: positive regulation of uredospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "positive regulation of ureidospore formation" EXACT [] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075252 ! regulation of uredospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075251 ! uredospore formation relationship: positively_regulates GO:0075251 ! uredospore formation [Term] id: GO:0075254 name: negative regulation of uredospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] synonym: "negative regulation of ureidospore formation" EXACT [] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075252 ! regulation of uredospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075251 ! uredospore formation relationship: negatively_regulates GO:0075251 ! uredospore formation [Term] id: GO:0075255 name: teliospore formation namespace: biological_process def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0075256 name: regulation of teliospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075255 ! teliospore formation relationship: regulates GO:0075255 ! teliospore formation [Term] id: GO:0075257 name: positive regulation of teliospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075256 ! regulation of teliospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075255 ! teliospore formation relationship: positively_regulates GO:0075255 ! teliospore formation [Term] id: GO:0075258 name: negative regulation of teliospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075256 ! regulation of teliospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075255 ! teliospore formation relationship: negatively_regulates GO:0075255 ! teliospore formation [Term] id: GO:0075259 name: spore-bearing structure development namespace: biological_process def: "The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] synonym: "fruiting structure development" EXACT [] synonym: "sporangium development" BROAD [] synonym: "spore-bearing organ development" RELATED [] synonym: "sporophore development" EXACT [] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0075260 name: regulation of spore-bearing organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075259 ! spore-bearing structure development relationship: regulates GO:0075259 ! spore-bearing structure development [Term] id: GO:0075261 name: positive regulation of spore-bearing organ development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0075260 ! regulation of spore-bearing organ development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075259 ! spore-bearing structure development relationship: positively_regulates GO:0075259 ! spore-bearing structure development [Term] id: GO:0075262 name: negative regulation of spore-bearing organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0075260 ! regulation of spore-bearing organ development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075259 ! spore-bearing structure development relationship: negatively_regulates GO:0075259 ! spore-bearing structure development [Term] id: GO:0075263 name: oogonium development namespace: biological_process def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075264 name: regulation of oogonium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075263 ! oogonium development relationship: regulates GO:0075263 ! oogonium development [Term] id: GO:0075265 name: positive regulation of oogonium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075264 ! regulation of oogonium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075263 ! oogonium development relationship: positively_regulates GO:0075263 ! oogonium development [Term] id: GO:0075266 name: negative regulation of oogonium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075264 ! regulation of oogonium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075263 ! oogonium development relationship: negatively_regulates GO:0075263 ! oogonium development [Term] id: GO:0075267 name: aecium development namespace: biological_process def: "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators] is_a: GO:0030582 ! reproductive fruiting body development [Term] id: GO:0075268 name: regulation of aecium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0031155 ! regulation of reproductive fruiting body development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075267 ! aecium development relationship: regulates GO:0075267 ! aecium development [Term] id: GO:0075269 name: positive regulation of aecium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075268 ! regulation of aecium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075267 ! aecium development relationship: positively_regulates GO:0075267 ! aecium development [Term] id: GO:0075270 name: negative regulation of aecium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075268 ! regulation of aecium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075267 ! aecium development relationship: negatively_regulates GO:0075267 ! aecium development [Term] id: GO:0075271 name: zygosporangium development namespace: biological_process def: "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075272 name: regulation of zygosporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075271 ! zygosporangium development relationship: regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075273 name: positive regulation of zygosporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075272 ! regulation of zygosporangium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075271 ! zygosporangium development relationship: positively_regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075274 name: negative regulation of zygosporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075272 ! regulation of zygosporangium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075271 ! zygosporangium development relationship: negatively_regulates GO:0075271 ! zygosporangium development [Term] id: GO:0075275 name: telium development namespace: biological_process def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075276 name: regulation of telium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075275 ! telium development relationship: regulates GO:0075275 ! telium development [Term] id: GO:0075277 name: positive regulation of telium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075276 ! regulation of telium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075275 ! telium development relationship: positively_regulates GO:0075275 ! telium development [Term] id: GO:0075278 name: negative regulation of telium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075276 ! regulation of telium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075275 ! telium development relationship: negatively_regulates GO:0075275 ! telium development [Term] id: GO:0075279 name: uredinium development namespace: biological_process def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] synonym: "development of uredium" EXACT [] is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075280 name: regulation of uredinium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075279 ! uredinium development relationship: regulates GO:0075279 ! uredinium development [Term] id: GO:0075281 name: positive regulation of uredinium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075280 ! regulation of uredinium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075279 ! uredinium development relationship: positively_regulates GO:0075279 ! uredinium development [Term] id: GO:0075282 name: negative regulation of uredinium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075280 ! regulation of uredinium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075279 ! uredinium development relationship: negatively_regulates GO:0075279 ! uredinium development [Term] id: GO:0075283 name: sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators] synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb] is_a: GO:0043934 ! sporulation [Term] id: GO:0075284 name: asexual sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators] is_a: GO:0030436 ! asexual sporulation is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore [Term] id: GO:0075285 name: sexual sporulation resulting in formation of a multicellular or syncytial spore namespace: biological_process def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0034293 ! sexual sporulation is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore intersection_of: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore intersection_of: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0075286 name: regulation of sporangiospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034300 ! sporangiospore formation relationship: regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075287 name: positive regulation of sporangiospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075286 ! regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034300 ! sporangiospore formation relationship: positively_regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075288 name: negative regulation of sporangiospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore is_a: GO:0075286 ! regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034300 ! sporangiospore formation relationship: negatively_regulates GO:0034300 ! sporangiospore formation [Term] id: GO:0075289 name: aplanospore formation namespace: biological_process def: "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0034300 ! sporangiospore formation [Term] id: GO:0075290 name: regulation of aplanospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075286 ! regulation of sporangiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075289 ! aplanospore formation relationship: regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075291 name: positive regulation of aplanospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075287 ! positive regulation of sporangiospore formation is_a: GO:0075290 ! regulation of aplanospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075289 ! aplanospore formation relationship: positively_regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075292 name: negative regulation of aplanospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] is_a: GO:0075288 ! negative regulation of sporangiospore formation is_a: GO:0075290 ! regulation of aplanospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075289 ! aplanospore formation relationship: negatively_regulates GO:0075289 ! aplanospore formation [Term] id: GO:0075293 name: response to host pH environment namespace: biological_process def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "response of symbiont to host pH environment" EXACT [] is_a: GO:0075136 ! response to host [Term] id: GO:0075294 name: positive regulation by symbiont of entry into host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by symbiont of entry into host" NARROW [] synonym: "up regulation by symbiont of entry into host" EXACT [] synonym: "up-regulation by symbiont of entry into host" EXACT [] synonym: "upregulation by symbiont of entry into host" EXACT [] is_a: GO:0052372 ! modulation by symbiont of entry into host is_a: GO:0075295 ! positive regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0075295 name: positive regulation by organism of entry into other organism involved in symbiotic interaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW [] synonym: "positive regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "up regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "upregulation by organism of entry into other organism during symbiotic interaction" RELATED [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0052371 ! regulation by organism of entry into other organism involved in symbiotic interaction [Term] id: GO:0075296 name: positive regulation of ascospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030437 ! ascospore formation relationship: positively_regulates GO:0030437 ! ascospore formation [Term] id: GO:0075297 name: negative regulation of ascospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030437 ! ascospore formation relationship: negatively_regulates GO:0030437 ! ascospore formation [Term] id: GO:0075298 name: regulation of zygospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034296 ! zygospore formation relationship: regulates GO:0034296 ! zygospore formation [Term] id: GO:0075299 name: positive regulation of zygospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034296 ! zygospore formation relationship: positively_regulates GO:0034296 ! zygospore formation [Term] id: GO:0075300 name: negative regulation of zygospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075298 ! regulation of zygospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034296 ! zygospore formation relationship: negatively_regulates GO:0034296 ! zygospore formation [Term] id: GO:0075301 name: obsolete cell differentiation involved in spore germination namespace: biological_process def: "OBSOLETE. The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl] comment: This term was made obsolete because it describes a process that doesn't exist. is_obsolete: true [Term] id: GO:0075302 name: regulation of basidiospore formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034295 ! basidiospore formation relationship: regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075303 name: positive regulation of basidiospore formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034295 ! basidiospore formation relationship: positively_regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075304 name: negative regulation of basidiospore formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore is_a: GO:0075302 ! regulation of basidiospore formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034295 ! basidiospore formation relationship: negatively_regulates GO:0034295 ! basidiospore formation [Term] id: GO:0075305 name: obsolete modulation of growth or development of symbiont on or near host namespace: biological_process def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of growth of symbiont on or near host ; GO:0044139' and 'modulation of development of symbiont on or near host ; GO:0044138'. synonym: "modulation of growth or development of symbiont on or near host" EXACT [] synonym: "modulation of growth or development of symbiont on or near host surface" EXACT [] is_obsolete: true consider: GO:0044138 [Term] id: GO:0075306 name: regulation of conidium formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048315 ! conidium formation relationship: regulates GO:0048315 ! conidium formation [Term] id: GO:0075307 name: positive regulation of conidium formation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0075306 ! regulation of conidium formation is_a: GO:1903666 ! positive regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048315 ! conidium formation relationship: positively_regulates GO:0048315 ! conidium formation [Term] id: GO:0075308 name: negative regulation of conidium formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0075306 ! regulation of conidium formation is_a: GO:1903665 ! negative regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048315 ! conidium formation relationship: negatively_regulates GO:0048315 ! conidium formation [Term] id: GO:0075309 name: obsolete negative regulation of growth or development of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont on or near host surface ; GO:0044141' and 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'. synonym: "negative regulation of growth or development of symbiont on or near host surface" EXACT [] is_obsolete: true consider: GO:0044141 [Term] id: GO:0075310 name: regulation of sporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043582 ! sporangium development relationship: regulates GO:0043582 ! sporangium development [Term] id: GO:0075311 name: positive regulation of sporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075310 ! regulation of sporangium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043582 ! sporangium development relationship: positively_regulates GO:0043582 ! sporangium development [Term] id: GO:0075312 name: negative regulation of sporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075310 ! regulation of sporangium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043582 ! sporangium development relationship: negatively_regulates GO:0043582 ! sporangium development [Term] id: GO:0075313 name: basidium development namespace: biological_process def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075314 name: regulation of basidium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075313 ! basidium development relationship: regulates GO:0075313 ! basidium development [Term] id: GO:0075315 name: positive regulation of basidium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075314 ! regulation of basidium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075313 ! basidium development relationship: positively_regulates GO:0075313 ! basidium development [Term] id: GO:0075316 name: negative regulation of basidium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075314 ! regulation of basidium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075313 ! basidium development relationship: negatively_regulates GO:0075313 ! basidium development [Term] id: GO:0075317 name: ascus development namespace: biological_process def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0075318 name: regulation of ascus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075260 ! regulation of spore-bearing organ development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075317 ! ascus development relationship: regulates GO:0075317 ! ascus development [Term] id: GO:0075319 name: positive regulation of ascus development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:0075318 ! regulation of ascus development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075317 ! ascus development relationship: positively_regulates GO:0075317 ! ascus development [Term] id: GO:0075320 name: negative regulation of ascus development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:0075318 ! regulation of ascus development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075317 ! ascus development relationship: negatively_regulates GO:0075317 ! ascus development [Term] id: GO:0075321 name: oomycete sporangium development namespace: biological_process def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators] is_a: GO:0030436 ! asexual sporulation is_a: GO:0043582 ! sporangium development [Term] id: GO:0075322 name: regulation of oomycete sporangium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0075310 ! regulation of sporangium development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075321 ! oomycete sporangium development relationship: regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075323 name: positive regulation of oomycete sporangium development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0043938 ! positive regulation of sporulation is_a: GO:0075311 ! positive regulation of sporangium development is_a: GO:0075322 ! regulation of oomycete sporangium development is_a: GO:1903666 ! positive regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075321 ! oomycete sporangium development relationship: positively_regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075324 name: negative regulation of oomycete sporangium development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] is_a: GO:0043939 ! negative regulation of sporulation is_a: GO:0075312 ! negative regulation of sporangium development is_a: GO:0075322 ! regulation of oomycete sporangium development is_a: GO:1903665 ! negative regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075321 ! oomycete sporangium development relationship: negatively_regulates GO:0075321 ! oomycete sporangium development [Term] id: GO:0075325 name: spore dispersal on or near host namespace: biological_process def: "Any process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0075326 name: active spore dispersal on or near host namespace: biological_process def: "Any active process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "active spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0075325 ! spore dispersal on or near host [Term] id: GO:0075327 name: passive spore dispersal on or near host namespace: biological_process def: "Any passive process in which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "passive spore dispersal on or near host during symbiotic interaction" EXACT [] is_a: GO:0075325 ! spore dispersal on or near host [Term] id: GO:0075328 name: formation by symbiont of arbuscule for nutrient acquisition from host namespace: biological_process def: "The assembly by an organism of an arbuscule, a fine, tree-like hyphal structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host [Term] id: GO:0075329 name: regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0044145 ! modulation of development of symbiont involved in interaction with host is_a: GO:0060259 ! regulation of feeding behavior relationship: regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075330 name: positive regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044149 ! positive regulation of development of symbiont involved in interaction with host is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host relationship: positively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075331 name: negative regulation of arbuscule formation for nutrient acquisition from host namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0044147 ! negative regulation of development of symbiont involved in interaction with host is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host relationship: negatively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host [Term] id: GO:0075332 name: obsolete modulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075333 name: obsolete positive regulation by host of symbiont adenylate cyclase-mediated signal transduction namespace: biological_process def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. is_obsolete: true [Term] id: GO:0075334 name: obsolete modulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true [Term] id: GO:0075335 name: obsolete positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true [Term] id: GO:0075336 name: obsolete negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host namespace: biological_process def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true [Term] id: GO:0075337 name: obsolete positive regulation of growth or development of symbiont on or near host surface namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont on or near host surface ; GO:0044143' and 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'. synonym: "positive regulation of growth or development of symbiont on or near host surface" EXACT [] is_obsolete: true consider: GO:0044143 [Term] id: GO:0075338 name: obsolete modulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of development of symbiont during interaction with host ; GO:0044145' and 'modulation of growth of symbiont during interaction with host ; GO:0044144'. synonym: "modulation of growth or development of symbiont during interaction with host" EXACT [] is_obsolete: true consider: GO:0044145 [Term] id: GO:0075339 name: obsolete positive regulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont during interaction with host ; GO:0044149' and 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. synonym: "positive regulation of growth or development of symbiont during interaction with host" EXACT [] is_obsolete: true [Term] id: GO:0075340 name: obsolete negative regulation of growth or development of symbiont during interaction with host namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with 'negative regulation of development of symbiont during interaction with host ; GO:0044147'. synonym: "negative regulation of growth or development of symbiont during interaction with host" EXACT [] is_obsolete: true consider: GO:0044147 [Term] id: GO:0075341 name: host cell PML body namespace: cellular_component def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl] synonym: "host cell PML NB" EXACT [] synonym: "host cell PML nuclear body" EXACT [] is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0075342 name: disruption by symbiont of host cell PML body namespace: biological_process def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl] synonym: "catabolism by symbiont of host cell PML body" EXACT [] synonym: "degradation by symbiont of host cell PML body" EXACT [] synonym: "disassembly by symbiont of host cell PML body" EXACT [] synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT [] synonym: "disassembly by symbiont of host cell PML NB" EXACT [] synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT [] is_a: GO:0052008 ! disruption by symbiont of host cellular component [Term] id: GO:0075343 name: modulation by symbiont of abscisic acid levels in host namespace: biological_process def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'. is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels [Term] id: GO:0075344 name: modulation by symbiont of host protein levels namespace: biological_process def: "The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. is_a: GO:0051817 ! modification of morphology or physiology of other organism involved in symbiotic interaction [Term] id: GO:0075345 name: modification by symbiont of host protein namespace: biological_process def: "The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that modify host proteins, consider annotation to 'protein modification process' GO:0006464. is_a: GO:0052228 ! metabolism by symbiont of host protein [Term] id: GO:0075346 name: modification by symbiont of host protein by ubiquitination namespace: biological_process def: "The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that ubiquitinate host proteins, consider annotation to 'protein ubiquitination ; GO:0016567'. synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT [] synonym: "modification by symbiont of host protein by ubiquitylation" EXACT [] is_a: GO:0075345 ! modification by symbiont of host protein [Term] id: GO:0075502 name: endosome membrane permeabilization involved in viral entry into host cell namespace: biological_process alt_id: GO:0075518 def: "Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization" RELATED [GOC:bf, GOC:jl] is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell created_by: jane creation_date: 2010-06-02T02:40:25Z [Term] id: GO:0075503 name: fusion of virus membrane with host macropinosome membrane namespace: biological_process def: "Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane" EXACT [] synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane" RELATED [GOC:bf, GOC:jl] is_a: GO:0039654 ! fusion of virus membrane with host endosome membrane created_by: jane creation_date: 2010-06-02T02:45:47Z [Term] id: GO:0075504 name: macropinosomal membrane permeabilization involved in viral entry into host cell namespace: biological_process def: "Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization" RELATED [GOC:bf, GOC:jl] is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell created_by: jane creation_date: 2010-06-02T02:48:36Z [Term] id: GO:0075505 name: entry of intact viral capsid into host nucleus through nuclear pore complex namespace: biological_process def: "Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC)." [PMID:22929056, VZ:989] comment: This mechanism is used by viruses with capsids small enough to cross the nuclear pore complex, such as the single-stranded (ss) DNA viruses Parvoviridae, Circoviridae and Geminiviridae. is_a: GO:0075732 ! viral penetration into host nucleus created_by: janelomax creation_date: 2011-07-26T04:35:03Z [Term] id: GO:0075506 name: entry of viral genome into host nucleus through nuclear pore complex via importin namespace: biological_process def: "Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery." [PMID:22929056, VZ:989] comment: This mechanism is used by some RNA viruses (e.g. Orthomyxoviridae), some dsDNA viruses (e.g. Polyomaviridae) and some ssRNA viruses (e.g. Lentivirus). synonym: "entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex" EXACT [GOC:jl] is_a: GO:0075732 ! viral penetration into host nucleus created_by: janelomax creation_date: 2011-07-26T04:36:46Z [Term] id: GO:0075507 name: entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome namespace: biological_process def: "Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm." [PMID:22929056, VZ:989] comment: This mechanism is used by viruses such as Herpesvirales whose capsid is too large to enter the nuclear pore complex (NPC) pore. is_a: GO:0075732 ! viral penetration into host nucleus created_by: janelomax creation_date: 2011-07-26T04:52:51Z [Term] id: GO:0075508 name: entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm namespace: biological_process def: "Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm." [PMID:22929056, VZ:989] comment: This mechanism is used by viruses such as Hepadnaviridae whose capsids enter the NPC but are too big to pass intact into the nucleus. synonym: "entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm" EXACT [GOC:jl] is_a: GO:0075732 ! viral penetration into host nucleus created_by: janelomax creation_date: 2011-07-26T04:56:10Z [Term] id: GO:0075509 name: endocytosis involved in viral entry into host cell namespace: biological_process def: "Any endocytosis that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, VZ:977] synonym: "viral entry into host cell via endocytosis" RELATED [GOC:bf, GOC:jl] synonym: "viral penetration via endocytosis followed by endosome disruption" EXACT [] synonym: "virus endocytosis by host" EXACT [UniProtKB-KW:KW-1164] xref: VZ:977 "Virus endocytosis by host" is_a: GO:0006897 ! endocytosis is_a: GO:0046794 ! transport of virus intersection_of: GO:0006897 ! endocytosis intersection_of: part_of GO:0046718 ! viral entry into host cell relationship: part_of GO:0046718 ! viral entry into host cell created_by: janelomax creation_date: 2011-07-27T11:06:34Z [Term] id: GO:0075510 name: macropinocytosis involved in viral entry into host cell namespace: biological_process def: "Any macropinocytosis that is involved in the uptake of a virus into a host cell." [GOC:jl, GOC:sp, PMID:17077125, PMID:19404330, VZ:800] synonym: "viral entry into host cell via macropinocytosis" RELATED [GOC:bf, GOC:jl] xref: VZ:800 "Macropinocytosis of virus by host" is_a: GO:0075509 ! endocytosis involved in viral entry into host cell is_a: GO:1902539 ! multi-organism macropinocytosis intersection_of: GO:1902539 ! multi-organism macropinocytosis intersection_of: part_of GO:0046718 ! viral entry into host cell created_by: janelomax creation_date: 2011-07-27T11:24:59Z [Term] id: GO:0075511 name: macropinosome lysis involved in viral entry into host cell namespace: biological_process def: "Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl] is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell created_by: janelomax creation_date: 2011-07-27T11:38:07Z [Term] id: GO:0075512 name: clathrin-dependent endocytosis of virus by host cell namespace: biological_process alt_id: GO:0075516 def: "Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus." [GOC:bf, GOC:jl, VZ:957] synonym: "clathrin-mediated endocytosis of virus by host cell" EXACT [] synonym: "viral entry into host cell via clathrin-mediated endocytosis" RELATED [GOC:bf, GOC:jl] synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis" NARROW [] synonym: "viral penetration via clathrin-mediated endocytosis" EXACT [GOC:sp] xref: VZ:957 "Clathrin-mediated endocytosis of virus by host" is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell is_a: GO:0072583 ! clathrin-dependent endocytosis intersection_of: GO:0072583 ! clathrin-dependent endocytosis intersection_of: part_of GO:0046718 ! viral entry into host cell created_by: janelomax creation_date: 2011-07-27T02:08:54Z [Term] id: GO:0075513 name: caveolin-mediated endocytosis of virus by host cell namespace: biological_process def: "Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus." [GOC:bf, GOC:jl, VZ:976] synonym: "viral entry into host cell via caveolae-mediated endocytosis" EXACT [GOC:bf, GOC:jl] synonym: "viral entry into host cell via caveolin-mediated endocytosis" RELATED [GOC:bf, GOC:jl] synonym: "viral penetration via caveolae-mediated endocytosis followed by endosome disruption" EXACT [] xref: VZ:976 "Caveolin-mediated endocytosis of virus by host" is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell is_a: GO:0072584 ! caveolin-mediated endocytosis intersection_of: GO:0072584 ! caveolin-mediated endocytosis intersection_of: part_of GO:0046718 ! viral entry into host cell created_by: janelomax creation_date: 2011-07-27T02:40:04Z [Term] id: GO:0075514 name: endosome lysis involved in viral entry into host cell namespace: biological_process def: "Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis" EXACT [GOC:bf, GOC:jl] is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell created_by: janelomax creation_date: 2011-07-27T02:56:15Z [Term] id: GO:0075515 name: obsolete viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane namespace: biological_process def: "OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl, VZ:976] comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis. synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [GOC:bf, GOC:jl] synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [] is_obsolete: true created_by: janelomax creation_date: 2011-07-27T02:57:55Z [Term] id: GO:0075519 name: microtubule-dependent intracellular transport of viral material namespace: biological_process def: "The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus." [VZ:983] is_a: GO:0075733 ! intracellular transport of virus created_by: janelomax creation_date: 2011-08-03T01:45:25Z [Term] id: GO:0075520 name: actin-dependent intracellular transport of virus namespace: biological_process def: "The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions." [UniProtKB-KW:KW-1178, VZ:991] synonym: "actin-dependent intracellular transport of viral material" EXACT [] xref: VZ:991 "Actin-dependent inwards viral transport" is_a: GO:0075733 ! intracellular transport of virus created_by: janelomax creation_date: 2011-08-03T01:45:55Z [Term] id: GO:0075521 name: microtubule-dependent intracellular transport of viral material towards nucleus namespace: biological_process def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983] synonym: "microtubule-dependent intracellular transport of viral material to nucleus" EXACT [GOC:jl] xref: VZ:983 "Microtubular inwards viral transport" is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material is_a: GO:0075606 ! transport of viral material towards nucleus created_by: janelomax creation_date: 2011-08-03T02:09:21Z [Term] id: GO:0075522 name: IRES-dependent viral translational initiation namespace: biological_process def: "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867] xref: VZ:867 "Viral initiation of translation: IRES and DLP" is_a: GO:0016032 ! viral process relationship: part_of GO:0019081 ! viral translation created_by: janelomax creation_date: 2011-08-03T02:25:03Z [Term] id: GO:0075523 name: viral translational frameshifting namespace: biological_process def: "A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins." [GOC:bf, GOC:ch, GOC:jl, PMID:24825891, PMID:8852897, VZ:860] comment: This term is intended to annotate gene products involved in the process of viral translational frameshifting, not viral proteins produced by this translation process. synonym: "ribosomal frameshifting involved in viral translation" EXACT [GOC:jl] xref: VZ:860 "Ribosomal frameshifting" is_a: GO:0016032 ! viral process relationship: part_of GO:0019081 ! viral translation created_by: janelomax creation_date: 2011-08-03T02:48:46Z [Term] id: GO:0075524 name: ribosomal skipping namespace: biological_process def: "A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue." [GOC:bf, GOC:ch, GOC:jl, VZ:914] comment: This term is intended to annotate gene products involved in the process of ribosomal skipping, not viral proteins produced by this translation process. xref: VZ:914 "Ribosomal skipping" is_a: GO:0016032 ! viral process relationship: part_of GO:0019081 ! viral translation created_by: janelomax creation_date: 2011-08-03T03:19:37Z [Term] id: GO:0075525 name: viral translational termination-reinitiation namespace: biological_process def: "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF." [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858] comment: This term is intended to annotate gene products involved in the process of viral translational termination-reinitiation, not viral proteins produced by this translation process. synonym: "termination reinitiation involved in viral translation" EXACT [GO:jl] synonym: "viral translation involving termination re-initiation" EXACT [GO:jl] synonym: "viral translation involving termination-reinitiation" EXACT [GO:jl] synonym: "viral translation involving translational stop-start" EXACT [GO:jl] xref: VZ:858 "RNA termination-reinitiation" is_a: GO:0016032 ! viral process relationship: part_of GO:0019081 ! viral translation created_by: janelomax creation_date: 2011-08-04T12:01:22Z [Term] id: GO:0075526 name: cap snatching namespace: biological_process def: "A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs." [GOC:bf, GOC:jl, VZ:839] synonym: "cap snatching involved in viral mRNA transcription" EXACT [GO:jl] xref: VZ:839 is_a: GO:0016032 ! viral process relationship: part_of GO:0039697 ! negative stranded viral RNA transcription created_by: janelomax creation_date: 2011-08-04T01:19:00Z [Term] id: GO:0075527 name: viral RNA editing namespace: biological_process def: "The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon." [PMID:1629949, VZ:857] synonym: "RNA editing involved in viral mRNA transcription" EXACT [GO:jl] xref: VZ:857 "RNA editing" is_a: GO:0016032 ! viral process relationship: part_of GO:0019083 ! viral transcription created_by: janelomax creation_date: 2011-08-04T02:07:03Z [Term] id: GO:0075528 name: modulation by virus of host immune response namespace: biological_process def: "The process in which a virus effects a change in the host immune response." [GOC:bf, GOC:jl] synonym: "regulation by virus of host immune system process" EXACT [GOC:jl] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052553 ! modulation by symbiont of host immune response created_by: janelomax creation_date: 2011-08-04T02:47:57Z [Term] id: GO:0075529 name: establishment of latency as a circular episome namespace: biological_process def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure." [GOC:jl] synonym: "establishment of circular plasmid latency" EXACT [] synonym: "establishment of latency as a circular plasmid" EXACT [] xref: PHI:0000054 is_a: GO:0075720 ! establishment of episomal latency created_by: janelomax creation_date: 2011-08-04T03:08:17Z [Term] id: GO:0075530 name: establishment of latency as a linear episome namespace: biological_process def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure." [GOC:jl] synonym: "establishment of latency as a linear plasmid" EXACT [] synonym: "establishment of linear plasmid latency" EXACT [] xref: PHI:0000053 is_a: GO:0075720 ! establishment of episomal latency created_by: janelomax creation_date: 2011-08-04T03:14:23Z [Term] id: GO:0075606 name: transport of viral material towards nucleus namespace: biological_process def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane." [GOC:bf, GOC:jl, VZ:990] comment: This process does not include the viral material crossing the nuclear membrane. For transport of viral material into the nucleus, consider instead: 'viral penetration into host nucleus ; GO:0075732'. synonym: "cytoplasmic inwards viral transport" EXACT [UniProtKB-KW:KW-1176, VZ:990] synonym: "transport of viral material to nucleus" EXACT [GOC:jl] synonym: "viral genome transport to host cell nucleus" EXACT [] xref: VZ:990 "Cytoplasmic inwards viral transport" is_a: GO:0075733 ! intracellular transport of virus created_by: jane creation_date: 2009-11-05T03:33:36Z [Term] id: GO:0075705 name: obsolete viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane namespace: biological_process def: "OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl] comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis. synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [] synonym: "viral penetration via endocytosis followed by genetic injection through the endosome membrane" EXACT [] is_obsolete: true created_by: jane creation_date: 2009-04-23T02:08:06Z [Term] id: GO:0075713 name: establishment of integrated proviral latency namespace: biological_process alt_id: GO:0019047 def: "A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage." [GOC:jl] synonym: "prophage integration" EXACT [] synonym: "provirus integration" EXACT [] xref: PHI:0000055 xref: VZ:980 "Viral genome integration" is_a: GO:0019043 ! establishment of viral latency relationship: has_part GO:0044826 ! viral genome integration into host DNA created_by: jane creation_date: 2009-05-07T02:28:41Z [Term] id: GO:0075720 name: establishment of episomal latency namespace: biological_process def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity." [GOC:jl] synonym: "establishment as a plasmid prophage" NARROW [] synonym: "establishment of plasmid latency" EXACT [] xref: PHI:0000051 is_a: GO:0019043 ! establishment of viral latency created_by: jane creation_date: 2009-11-26T03:57:44Z [Term] id: GO:0075732 name: viral penetration into host nucleus namespace: biological_process def: "The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid." [PMID:22929056, VZ:989] synonym: "viral entry into host nucleus" EXACT [] synonym: "viral import into host nucleus" EXACT [] xref: VZ:989 "Viral penetration into host nucleus" is_a: GO:0075733 ! intracellular transport of virus is_a: GO:1902594 ! multi-organism nuclear import created_by: jane creation_date: 2009-05-01T02:43:16Z [Term] id: GO:0075733 name: intracellular transport of virus namespace: biological_process alt_id: GO:0046788 alt_id: GO:0046795 alt_id: GO:0046796 def: "The directed movement of a virus, or part of a virus, within the host cell." [GOC:ai, GOC:bf, GOC:jl, PMID:11733033] synonym: "egress of virus within host cell" EXACT [] synonym: "intracellular transport of viral material" EXACT [GOC:bf, GOC:jl] synonym: "intracellular virion transport" RELATED [] synonym: "movement of virus within host cell" EXACT [] synonym: "viral egress" RELATED [] synonym: "viral genome transport in host cell" EXACT [] is_a: GO:0046794 ! transport of virus intersection_of: GO:0046794 ! transport of virus intersection_of: occurs_in GO:0043657 ! host cell relationship: occurs_in GO:0043657 ! host cell relationship: part_of GO:0019058 ! viral life cycle created_by: jane creation_date: 2009-05-01T04:01:33Z [Term] id: GO:0080001 name: mucilage extrusion from seed coat namespace: biological_process def: "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922] synonym: "mucilage release from seed coat" RELATED [] synonym: "secretion of mucilage from seed coat" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0009845 ! seed germination relationship: part_of GO:0048316 ! seed development [Term] id: GO:0080002 name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129] synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED [] synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED [] synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED [] xref: MetaCyc:RXN-6142 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080003 name: thalianol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490] synonym: "thalianol metabolism" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process [Term] id: GO:0080004 name: thalian-diol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490] xref: EC:1.14.21 xref: MetaCyc:RXN-9637 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0080005 name: photosystem stoichiometry adjustment namespace: biological_process def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105] is_a: GO:0010109 ! regulation of photosynthesis [Term] id: GO:0080006 name: internode patterning namespace: biological_process def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0080007 name: S-nitrosoglutathione reductase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+." [MetaCyc:RXN-10742, PMID:11260719] xref: MetaCyc:RXN-10742 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0080008 name: Cul4-RING E3 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0080009 name: mRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] is_a: GO:0001510 ! RNA methylation is_a: GO:0016556 ! mRNA modification [Term] id: GO:0080010 name: obsolete regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "regulation of oxygen and reactive oxygen species metabolic process" EXACT [] is_obsolete: true consider: GO:2000374 consider: GO:2000377 [Term] id: GO:0080011 name: baruol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [MetaCyc:RXN-9685, PMID:17705488] xref: EC:5.4.99 xref: MetaCyc:RXN-9685 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0080012 name: trihydroxyferuloyl spermidine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+." [PMID:18557837] synonym: "N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity" EXACT [MetaCyc:RXN-11263] xref: MetaCyc:RXN-11263 is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0080013 name: (E,E)-geranyllinalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052] xref: MetaCyc:RXN-10441 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0080014 name: thalianol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X." [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490] comment: In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008). xref: EC:1.14.13 xref: MetaCyc:RXN-9631 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0080015 name: sabinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540] xref: EC:4.2.3 xref: MetaCyc:RXN-5103 is_a: GO:0009975 ! cyclase activity is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0080016 name: (-)-E-beta-caryophyllene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047] xref: EC:4.2.3 xref: MetaCyc:RXN-8414 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0080017 name: alpha-humulene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047] xref: EC:4.2.3 xref: MetaCyc:RXN-8415 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity [Term] id: GO:0080018 name: anthocyanin 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP." [PMID:15807784] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080019 name: fatty-acyl-CoA reductase (alcohol-forming) activity namespace: molecular_function def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] synonym: "fatty acyl CoA reductase (alcohol-forming) activity" EXACT [] synonym: "fatty acyl-CoA reductase (alcohol-forming) activity" EXACT [GOC:mah] is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0080020 name: regulation of coenzyme A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975] is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015937 ! coenzyme A biosynthetic process relationship: regulates GO:0015937 ! coenzyme A biosynthetic process [Term] id: GO:0080021 name: response to benzoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285] synonym: "response to benzoic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0080022 name: primary root development namespace: biological_process def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl] is_a: GO:0048364 ! root development [Term] id: GO:0080023 name: 3R-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622] xref: Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0080024 name: indolebutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356] synonym: "IBA metabolic process" EXACT [] synonym: "IBA metabolism" EXACT [] synonym: "indole-3-butyric acid metabolic process" NARROW [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0080025 name: phosphatidylinositol-3,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324] synonym: "PtdIns(3,5)P2 binding" EXACT [] is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding [Term] id: GO:0080026 name: response to indolebutyric acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356] synonym: "response to IBA stimulus" EXACT [] synonym: "response to indole-3-butyric acid stimulus" NARROW [] synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009733 ! response to auxin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0080027 name: response to herbivore namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211] is_a: GO:0051707 ! response to other organism [Term] id: GO:0080028 name: nitrile biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0050898 ! nitrile metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0080029 name: cellular response to boron-containing substance levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances." [PMID:18952773] synonym: "cellular response to boron levels" EXACT [] is_a: GO:0010036 ! response to boron-containing substance is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0080030 name: methyl indole-3-acetate esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+." [MetaCyc:RXN-10711, PMID:18467465] synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT [] synonym: "MeIAA esterase activity" EXACT [] synonym: "Methyl IAA esterase activity" EXACT [] synonym: "methyl indole-3-acetate esterase activity" RELATED [] xref: EC:3.1.1.1 xref: MetaCyc:RXN-10711 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080031 name: methyl salicylate esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+." [MetaCyc:RXNQT-4366, PMID:18467465, PMID:18643994] synonym: "MESA esterase activity" EXACT [] synonym: "methyl SA esterase activity" EXACT [] synonym: "methylsalicylate esterase activity" EXACT [] synonym: "salicylic acid methyl ester esterase activity" EXACT [] xref: MetaCyc:RXNQT-4366 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080032 name: methyl jasmonate esterase activity namespace: molecular_function def: "Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol." [PMID:15233793, PMID:18467465] synonym: "jasmonic acid methyl ester esterase activity" EXACT [] synonym: "MEJA esterase activity" EXACT [] synonym: "methyl JA esterase activity" EXACT [] xref: MetaCyc:RXN-10767 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0080033 name: response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:dhl, PMID:17951451] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0080034 name: host response to induction by symbiont of tumor, nodule or growth in host namespace: biological_process def: "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0080035 name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935] synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT [] synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" EXACT [] synonym: "progoitrin biosynthesis" EXACT [] synonym: "progoitrin biosynthetic process" EXACT [] synonym: "progoitrin synthesis" EXACT [] is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0080036 name: regulation of cytokinin-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokinin signaling." [GOC:dhl] synonym: "regulation of cytokinin mediated signaling pathway" RELATED [] synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009736 ! cytokinin-activated signaling pathway relationship: regulates GO:0009736 ! cytokinin-activated signaling pathway [Term] id: GO:0080037 name: negative regulation of cytokinin-activated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling." [GOC:dhl, PMID:14973166] synonym: "negative regulation of cytokinin mediated signaling pathway" RELATED [] synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway relationship: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway [Term] id: GO:0080038 name: positive regulation of cytokinin-activated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokinin signaling." [GOC:dhl] synonym: "positive regulation of cytokinin mediated signaling pathway" RELATED [] synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway relationship: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway [Term] id: GO:0080040 name: positive regulation of cellular response to phosphate starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0140255 ! regulation of cellular response to phosphate starvation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016036 ! cellular response to phosphate starvation relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation [Term] id: GO:0080041 name: ADP-ribose pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb] is_a: GO:0019144 ! ADP-sugar diphosphatase activity [Term] id: GO:0080042 name: ADP-glucose pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb] is_a: GO:0019144 ! ADP-sugar diphosphatase activity [Term] id: GO:0080043 name: quercetin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080044 name: quercetin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080045 name: quercetin 3'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060] is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080046 name: quercetin 4'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060] xref: MetaCyc:RXN-10788 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0080047 name: GDP-L-galactose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [EC:2.7.7.69, PMID:18463094] xref: EC:2.7.7.69 xref: MetaCyc:RXNQT-4141 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0080048 name: GDP-D-glucose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094] xref: EC:2.7.7.78 xref: MetaCyc:RXN-12486 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] id: GO:0080049 name: L-gulono-1,4-lactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525] xref: MetaCyc:RXN-1439 is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: GO:0080050 name: regulation of seed development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048316 ! seed development relationship: regulates GO:0048316 ! seed development [Term] id: GO:0080051 name: cutin transport namespace: biological_process def: "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0080052 name: response to histidine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid [Term] id: GO:0080053 name: response to phenylalanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid [Term] id: GO:0080054 name: low-affinity nitrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168] synonym: "low affinity nitrate transmembrane transporter activity" EXACT [] is_a: GO:0015112 ! nitrate transmembrane transporter activity [Term] id: GO:0080056 name: petal vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435] is_a: GO:0010051 ! xylem and phloem pattern formation created_by: donghui creation_date: 2009-04-13T02:25:01Z [Term] id: GO:0080057 name: sepal vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435] is_a: GO:0010051 ! xylem and phloem pattern formation created_by: donghui creation_date: 2009-04-13T02:26:19Z [Term] id: GO:0080058 name: protein deglutathionylation namespace: biological_process def: "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb] synonym: "protein amino acid deglutathionylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process created_by: donghui creation_date: 2009-04-13T02:48:06Z [Term] id: GO:0080059 name: flavonol 3-O-arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557] is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0052636 ! arabinosyltransferase activity created_by: donghui creation_date: 2009-04-13T02:55:11Z [Term] id: GO:0080060 name: integument development namespace: biological_process def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0048481 ! plant ovule development created_by: donghui creation_date: 2009-04-13T02:58:07Z [Term] id: GO:0080061 name: indole-3-acetonitrile nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3." [EC:3.5.5.1, MetaCyc:RXN-1404] is_a: GO:0000257 ! nitrilase activity created_by: donghui creation_date: 2009-04-13T03:30:42Z [Term] id: GO:0080062 name: cytokinin 9-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [KEGG_REACTION:R08369, PMID:15342621] xref: EC:2.4.1 xref: KEGG_REACTION:R08369 is_a: GO:0035251 ! UDP-glucosyltransferase activity created_by: donghui creation_date: 2009-04-13T03:34:38Z [Term] id: GO:0080064 name: 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation namespace: biological_process def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780] synonym: "4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity" RELATED [] is_a: GO:0034440 ! lipid oxidation created_by: donghui creation_date: 2009-04-13T03:39:58Z [Term] id: GO:0080065 name: 4-alpha-methyl-delta7-sterol oxidation namespace: biological_process def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780] synonym: "4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity" RELATED [] is_a: GO:0034440 ! lipid oxidation created_by: donghui creation_date: 2009-04-13T03:41:50Z [Term] id: GO:0080066 name: 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXN-2209 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:04:08Z [Term] id: GO:0080067 name: 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXNQT-4329 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:05:53Z [Term] id: GO:0080068 name: 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXNQT-4330 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:06:59Z [Term] id: GO:0080069 name: 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXNQT-4332 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:07:32Z [Term] id: GO:0080070 name: 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXNQT-4333 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:07:58Z [Term] id: GO:0080071 name: indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] xref: MetaCyc:RXN-1443 is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity created_by: donghui creation_date: 2009-04-13T04:08:33Z [Term] id: GO:0080072 name: spermidine:sinapoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity created_by: donghui creation_date: 2009-04-13T04:16:28Z [Term] id: GO:0080073 name: spermidine:coumaroyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity created_by: donghui creation_date: 2009-04-13T04:16:59Z [Term] id: GO:0080074 name: spermidine:caffeoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity created_by: donghui creation_date: 2009-04-13T04:17:23Z [Term] id: GO:0080075 name: spermidine:feruloyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] is_a: GO:0016410 ! N-acyltransferase activity created_by: donghui creation_date: 2009-04-13T04:17:50Z [Term] id: GO:0080076 name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity created_by: donghui creation_date: 2009-04-14T03:55:49Z [Term] id: GO:0080077 name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity created_by: donghui creation_date: 2009-04-14T04:00:45Z [Term] id: GO:0080078 name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165] is_a: GO:0008171 ! O-methyltransferase activity created_by: donghui creation_date: 2009-04-14T04:01:25Z [Term] id: GO:0080079 name: cellobiose glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cellobiose + H2O = 2 D-glucose." [PMID:15604686] synonym: "cellobiose glucohydrolase activity" EXACT [] xref: MetaCyc:RXN-10773 is_a: GO:0008422 ! beta-glucosidase activity created_by: donghui creation_date: 2009-04-14T04:07:16Z [Term] id: GO:0080081 name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity created_by: donghui creation_date: 2009-04-14T04:09:06Z [Term] id: GO:0080082 name: esculin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity created_by: donghui creation_date: 2009-04-14T04:09:42Z [Term] id: GO:0080083 name: beta-gentiobiose beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686] is_a: GO:0008422 ! beta-glucosidase activity created_by: donghui creation_date: 2009-04-14T04:10:14Z [Term] id: GO:0080084 name: 5S rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688] is_a: GO:0000182 ! rDNA binding created_by: donghui creation_date: 2009-04-22T02:32:20Z [Term] id: GO:0080085 name: signal recognition particle, chloroplast targeting namespace: cellular_component def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500] is_a: GO:0048500 ! signal recognition particle created_by: donghui creation_date: 2009-04-22T02:36:01Z [Term] id: GO:0080086 name: stamen filament development namespace: biological_process def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067] synonym: "filament development" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048443 ! stamen development created_by: donghui creation_date: 2009-04-22T03:12:03Z [Term] id: GO:0080088 name: spermidine hydroxycinnamate conjugate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165] is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: donghui creation_date: 2009-04-22T03:24:03Z [Term] id: GO:0080089 name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative." [PMID:19168716] is_a: GO:0016410 ! N-acyltransferase activity created_by: donghui creation_date: 2009-04-22T03:27:55Z [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044238 ! primary metabolic process relationship: regulates GO:0044238 ! primary metabolic process created_by: donghui creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080091 name: regulation of raffinose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694] is_a: GO:0006109 ! regulation of carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033530 ! raffinose metabolic process relationship: regulates GO:0033530 ! raffinose metabolic process created_by: donghui creation_date: 2009-04-22T04:36:27Z [Term] id: GO:0080092 name: regulation of pollen tube growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0051510 ! regulation of unidimensional cell growth is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009860 ! pollen tube growth relationship: regulates GO:0009860 ! pollen tube growth created_by: donghui creation_date: 2009-04-22T04:41:29Z [Term] id: GO:0080093 name: regulation of photorespiration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009853 ! photorespiration relationship: regulates GO:0009853 ! photorespiration created_by: donghui creation_date: 2009-04-22T04:44:48Z [Term] id: GO:0080094 name: response to trehalose-6-phosphate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861] synonym: "response to trehalose-6-phosphate stimulus" EXACT [GOC:dos] is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound created_by: donghui creation_date: 2009-04-22T04:49:13Z [Term] id: GO:0080095 name: phosphatidylethanolamine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547] is_a: GO:0008374 ! O-acyltransferase activity created_by: donghui creation_date: 2009-04-23T03:39:33Z [Term] id: GO:0080096 name: phosphatidate-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547] is_a: GO:0008374 ! O-acyltransferase activity created_by: donghui creation_date: 2009-04-23T03:41:42Z [Term] id: GO:0080097 name: L-tryptophan:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine." [MetaCyc:RXN-10139] comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate = 3-(indol-3-yl)pyruvate). xref: EC:2.6.1.28 xref: MetaCyc:RXN-10139 xref: RHEA:27587 is_a: GO:0070529 ! L-tryptophan aminotransferase activity created_by: donghui creation_date: 2009-04-23T03:45:23Z [Term] id: GO:0080098 name: L-tyrosine:pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine." [MetaCyc:RXN3O-4157] xref: EC:2.6.1.58 xref: MetaCyc:RXN3O-4157 is_a: GO:0070547 ! L-tyrosine aminotransferase activity created_by: donghui creation_date: 2009-04-23T03:47:53Z [Term] id: GO:0080099 name: L-methionine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5). synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT [] is_a: GO:0010326 ! methionine-oxo-acid transaminase activity created_by: donghui creation_date: 2009-04-23T03:51:20Z [Term] id: GO:0080100 name: L-glutamine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50). synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT [] xref: EC:2.6.1.50 is_a: GO:0070548 ! L-glutamine aminotransferase activity created_by: donghui creation_date: 2009-04-23T03:56:16Z [Term] id: GO:0080101 name: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [EC:2.1.1.71, PMID:19366698] xref: EC:2.1.1.71 xref: KEGG_REACTION:R01320 xref: MetaCyc:RXN4FS-2 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: donghui creation_date: 2009-04-23T04:02:41Z [Term] id: GO:0080102 name: 3-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate." [PMID:18799661] xref: MetaCyc:RXN-2221 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:26:41Z [Term] id: GO:0080103 name: 4-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:27:45Z [Term] id: GO:0080104 name: 5-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:28:25Z [Term] id: GO:0080105 name: 6-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:28:55Z [Term] id: GO:0080106 name: 7-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:29:37Z [Term] id: GO:0080107 name: 8-methylthiopropyl glucosinolate S-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate." [PMID:18799661] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: donghui creation_date: 2009-04-23T04:30:08Z [Term] id: GO:0080108 name: S-alkylthiohydroximate lyase activity namespace: molecular_function def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316] synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW [] is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: donghui creation_date: 2009-04-23T04:35:14Z [Term] id: GO:0080109 name: indole-3-acetonitrile nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide." [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025] xref: EC:4.2.1.84 xref: KEGG_REACTION:R04020 xref: MetaCyc:RXN-7567 is_a: GO:0018822 ! nitrile hydratase activity created_by: donghui creation_date: 2009-04-23T04:37:57Z [Term] id: GO:0080110 name: sporopollenin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397] synonym: "sporopollenin biosynthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process relationship: part_of GO:0010584 ! pollen exine formation created_by: donghui creation_date: 2009-04-23T04:44:16Z [Term] id: GO:0080111 name: DNA demethylation namespace: biological_process def: "The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187] is_a: GO:0035510 ! DNA dealkylation is_a: GO:0044728 ! DNA methylation or demethylation is_a: GO:0070988 ! demethylation created_by: donghui creation_date: 2009-04-27T02:42:05Z [Term] id: GO:0080112 name: seed growth namespace: biological_process def: "The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048316 ! seed development created_by: donghui creation_date: 2009-04-27T02:52:07Z [Term] id: GO:0080113 name: regulation of seed growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706] synonym: "regulation of seed size" EXACT [] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0080050 ! regulation of seed development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080112 ! seed growth relationship: regulates GO:0080112 ! seed growth created_by: donghui creation_date: 2009-04-27T02:55:01Z [Term] id: GO:0080114 name: positive regulation of glycine hydroxymethyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1, PMID:19223513] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051347 ! positive regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004372 ! glycine hydroxymethyltransferase activity relationship: positively_regulates GO:0004372 ! glycine hydroxymethyltransferase activity created_by: donghui creation_date: 2009-04-27T03:27:15Z [Term] id: GO:0080115 name: myosin XI tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin XI heavy chain." [PMID:18703495] is_a: GO:0032029 ! myosin tail binding created_by: donghui creation_date: 2009-04-27T03:31:45Z [Term] id: GO:0080116 name: glucuronoxylan glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649] is_a: GO:0015020 ! glucuronosyltransferase activity created_by: donghui creation_date: 2009-04-27T03:33:49Z [Term] id: GO:0080117 name: secondary growth namespace: biological_process def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium." [ISBN:0471245208, PMID:19074290, PO:0005598, PO:0025004] comment: Occurs in vascular plants, including gymnosperms and most dicotyledons. Commonly supplemented by activity of the cork cambium or phellogen (PO:0005599). Monocotyledons do not have secondary growth, but may undergo primary thickening (GO:0080192) or secondary thickening (GO:0080191), which can give the appearance of secondary growth. Primary and secondary growth can occur simultaneously in the same organism. synonym: "cambial secondary growth" EXACT [] is_a: GO:0080190 ! lateral growth created_by: donghui creation_date: 2009-04-27T03:36:28Z [Term] id: GO:0080118 name: brassinosteroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative." [CHEBI:22921, PMID:10409637, PMID:17039368] is_a: GO:0008146 ! sulfotransferase activity created_by: donghui creation_date: 2009-04-27T03:39:36Z [Term] id: GO:0080119 name: ER body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648] synonym: "endoplasmic reticulum body organization" EXACT [] synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah] synonym: "ER body organisation" EXACT [GOC:mah] synonym: "ER body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization created_by: donghui creation_date: 2009-04-27T04:01:26Z [Term] id: GO:0080120 name: CAAX-box protein maturation namespace: biological_process def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086] synonym: "CAAX-box protein processing" RELATED [] synonym: "farnesylated protein maturation" RELATED [GOC:vw] is_a: GO:0044267 ! cellular protein metabolic process is_a: GO:0051604 ! protein maturation relationship: has_part GO:0016485 ! protein processing relationship: has_part GO:0018342 ! protein prenylation created_by: donghui creation_date: 2009-04-28T03:06:13Z [Term] id: GO:0080121 name: AMP transport namespace: biological_process def: "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18923018] synonym: "adenosine monophosphate transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0015893 ! drug transport is_a: GO:0051503 ! adenine nucleotide transport created_by: donghui creation_date: 2009-04-28T04:01:37Z [Term] id: GO:0080122 name: AMP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018] synonym: "adenosine monophosphate transmembrane transporter activity" EXACT [] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity relationship: part_of GO:0080121 ! AMP transport created_by: donghui creation_date: 2009-04-28T04:05:39Z [Term] id: GO:0080123 name: jasmonate-amino synthetase activity namespace: molecular_function def: "Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)." [PMID:15258265, PMID:17291501] synonym: "ja-amino synthetase activity" EXACT [] synonym: "jasmonate-amido synthetase activity" EXACT [] synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT [] synonym: "jasmonate-amino acid synthetase activity" EXACT [] synonym: "jasmonate:amino acid synthetase activity" EXACT [] synonym: "jasmonic acid-amino synthetase activity" EXACT [] synonym: "jasmonyl-amino synthetase activity" EXACT [] is_a: GO:0016881 ! acid-amino acid ligase activity created_by: donghui creation_date: 2009-04-28T04:08:35Z [Term] id: GO:0080124 name: pheophytinase activity namespace: molecular_function def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936] synonym: "pheophytin pheophorbide hydrolase activity" EXACT [] is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: donghui creation_date: 2009-04-28T04:16:11Z [Term] id: GO:0080125 name: obsolete multicellular structure septum development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl] comment: This term was made obsolete because it is not a useful grouping term. is_obsolete: true created_by: donghui creation_date: 2009-04-28T04:31:14Z [Term] id: GO:0080126 name: ovary septum development namespace: biological_process def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:1905328 ! plant septum development relationship: part_of GO:0035670 ! plant-type ovary development created_by: donghui creation_date: 2009-04-28T04:34:39Z [Term] id: GO:0080127 name: fruit septum development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009791 ! post-embryonic development is_a: GO:1905328 ! plant septum development relationship: part_of GO:0010154 ! fruit development created_by: donghui creation_date: 2009-04-28T04:37:19Z [Term] id: GO:0080128 name: anther septum development namespace: biological_process def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:1905328 ! plant septum development relationship: part_of GO:0048653 ! anther development created_by: donghui creation_date: 2009-04-28T04:41:16Z [Term] id: GO:0080129 name: proteasome core complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041] synonym: "20S proteasome assembly" EXACT [] is_a: GO:0043248 ! proteasome assembly created_by: donghui creation_date: 2009-04-29T03:34:50Z [Term] id: GO:0080130 name: L-phenylalanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57). synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT [] xref: EC:2.6.1.57 xref: KEGG_REACTION:R00694 xref: MetaCyc:PHEAMINOTRANS-RXN xref: MetaCyc:RXN-10814 xref: RHEA:25152 is_a: GO:0008793 ! aromatic-amino-acid:2-oxoglutarate aminotransferase activity is_a: GO:0070546 ! L-phenylalanine aminotransferase activity created_by: donghui creation_date: 2009-04-29T03:42:47Z [Term] id: GO:0080131 name: hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate." [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544] synonym: "11-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "11-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "11-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10453] synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "12-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10451] synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT [] synonym: "OHJA sulfotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity created_by: donghui creation_date: 2009-04-29T03:47:12Z [Term] id: GO:0080132 name: fatty acid alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355] synonym: "fatty acid 2-hydroxylase" EXACT [] xref: Reactome:R-HSA-5693761 "FA2H hydroxylates CERA" is_a: GO:0016491 ! oxidoreductase activity created_by: donghui creation_date: 2009-05-06T04:43:36Z [Term] id: GO:0080133 name: midchain alkane hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869] is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen created_by: donghui creation_date: 2009-05-06T04:46:17Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006950 ! response to stress relationship: regulates GO:0006950 ! response to stress created_by: donghui creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033554 ! cellular response to stress relationship: regulates GO:0033554 ! cellular response to stress created_by: donghui creation_date: 2009-05-06T05:02:52Z [Term] id: GO:0080136 name: priming of cellular response to stress namespace: biological_process def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610] synonym: "priming of response to stress" BROAD [] synonym: "priming of stress response" BROAD [] is_a: GO:0080135 ! regulation of cellular response to stress relationship: part_of GO:0033554 ! cellular response to stress created_by: donghui creation_date: 2009-05-06T05:05:15Z [Term] id: GO:0080139 name: borate efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465] synonym: "boron efflux transmembrane transporter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity relationship: part_of GO:0035445 ! borate transmembrane transport created_by: donghui creation_date: 2009-05-19T04:11:45Z [Term] id: GO:0080140 name: regulation of jasmonic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009694 ! jasmonic acid metabolic process relationship: regulates GO:0009694 ! jasmonic acid metabolic process created_by: donghui creation_date: 2009-05-19T04:24:55Z [Term] id: GO:0080141 name: regulation of jasmonic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0080140 ! regulation of jasmonic acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009695 ! jasmonic acid biosynthetic process relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process created_by: donghui creation_date: 2009-05-19T04:28:39Z [Term] id: GO:0080142 name: regulation of salicylic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl] is_a: GO:0010337 ! regulation of salicylic acid metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009697 ! salicylic acid biosynthetic process relationship: regulates GO:0009697 ! salicylic acid biosynthetic process created_by: donghui creation_date: 2009-05-19T04:38:23Z [Term] id: GO:0080143 name: regulation of amino acid export namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1903789 ! regulation of amino acid transmembrane transport relationship: regulates GO:0032973 ! amino acid export across plasma membrane created_by: donghui creation_date: 2010-01-20T04:43:56Z [Term] id: GO:0080144 name: amino acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell." [PMID:19955263] is_a: GO:0055081 ! anion homeostasis created_by: donghui creation_date: 2010-01-27T04:47:27Z [Term] id: GO:0080145 name: cysteine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell." [PMID:19955263] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: donghui creation_date: 2010-01-27T04:49:14Z [Term] id: GO:0080146 name: L-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263] xref: EC:4.4.1.1 xref: MetaCyc:LCYSDESULF-RXN xref: Reactome:R-HSA-1614591 "Excess cysteine yields lanthionine and H2S" xref: Reactome:R-HSA-1614614 "Cysteine is degraded to serine and H2S" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: donghui creation_date: 2010-01-27T04:50:43Z [Term] id: GO:0080147 name: root hair cell development namespace: biological_process def: "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state." [PMID:19675148] is_a: GO:0048468 ! cell development relationship: part_of GO:0048765 ! root hair cell differentiation created_by: donghui creation_date: 2010-03-26T01:45:08Z [Term] id: GO:0080148 name: negative regulation of response to water deprivation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [PMID:18835996] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000070 ! regulation of response to water deprivation relationship: negatively_regulates GO:0009414 ! response to water deprivation created_by: donghui creation_date: 2010-03-26T01:58:11Z [Term] id: GO:0080149 name: sucrose induced translational repression namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level." [PMID:19403731] synonym: "negative regulation of translation in response to sucrose" EXACT [] is_a: GO:0032055 ! negative regulation of translation in response to stress created_by: donghui creation_date: 2010-03-26T04:13:15Z [Term] id: GO:0080150 name: S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939] synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT [] xref: MetaCyc:RXN-6722 is_a: GO:0008171 ! O-methyltransferase activity created_by: donghui creation_date: 2010-03-26T04:19:39Z [Term] id: GO:0080151 name: positive regulation of salicylic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction." [PMID:20181750] synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway is_a: GO:2001040 ! positive regulation of cellular response to drug relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway created_by: donghui creation_date: 2010-05-20T03:10:46Z [Term] id: GO:0080152 name: regulation of reductive pentose-phosphate cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle." [PMID:17031544] synonym: "regulation of C3 photosynthesis" NARROW [] synonym: "regulation of Calvin cycle" NARROW [] is_a: GO:0010110 ! regulation of photosynthesis, dark reaction relationship: regulates GO:0019253 ! reductive pentose-phosphate cycle created_by: donghui creation_date: 2010-07-01T02:49:55Z [Term] id: GO:0080153 name: negative regulation of reductive pentose-phosphate cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle." [PMID:17031544, PMID:20399532] synonym: "negative regulation of C3 photosynthesis" NARROW [] synonym: "negative regulation of Calvin cycle" NARROW [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0080152 ! regulation of reductive pentose-phosphate cycle is_a: GO:1905156 ! negative regulation of photosynthesis relationship: negatively_regulates GO:0019253 ! reductive pentose-phosphate cycle created_by: donghui creation_date: 2010-07-01T02:55:27Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009566 ! fertilization relationship: regulates GO:0009566 ! fertilization created_by: donghui creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0080155 name: regulation of double fertilization forming a zygote and endosperm namespace: biological_process def: "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:DHL, PMID:20478994] is_a: GO:0080154 ! regulation of fertilization relationship: regulates GO:0009567 ! double fertilization forming a zygote and endosperm created_by: donghui creation_date: 2010-09-01T03:46:39Z [Term] id: GO:0080156 name: mitochondrial mRNA modification namespace: biological_process def: "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [PMID:20566637] synonym: "mitochondrial mRNA editing" NARROW [] synonym: "mitochondrial RNA editing" BROAD [] is_a: GO:0016556 ! mRNA modification is_a: GO:1900864 ! mitochondrial RNA modification intersection_of: GO:0016556 ! mRNA modification intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: donghui creation_date: 2010-09-01T03:55:48Z [Term] id: GO:0080157 name: regulation of plant-type cell wall organization or biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [PMID:20530756] synonym: "regulation of plant-type cell wall organisation or biogenesis" EXACT [GOC:mah] is_a: GO:1903338 ! regulation of cell wall organization or biogenesis relationship: regulates GO:0071669 ! plant-type cell wall organization or biogenesis created_by: donghui creation_date: 2010-09-01T04:02:37Z [Term] id: GO:0080158 name: obsolete chloroplast ribulose bisphosphate carboxylase complex biogenesis namespace: biological_process def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [PMID:20561259] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 is_obsolete: true created_by: donghui creation_date: 2010-09-01T04:05:55Z [Term] id: GO:0080159 name: zygote elongation namespace: biological_process def: "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana." [GOC:tb] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0048598 ! embryonic morphogenesis created_by: donghui creation_date: 2010-09-01T04:07:51Z [Term] id: GO:0080160 name: selenate transport namespace: biological_process def: "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18761637] is_a: GO:0015698 ! inorganic anion transport created_by: donghui creation_date: 2010-09-01T04:17:38Z [Term] id: GO:0080161 name: auxin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth." [PMID:19506555] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0060918 ! auxin transport created_by: donghui creation_date: 2010-09-23T03:37:43Z [Term] id: GO:0080162 name: intracellular auxin transport namespace: biological_process def: "The directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth." [PMID:19506555] is_a: GO:0046907 ! intracellular transport is_a: GO:0060919 ! auxin influx intersection_of: GO:0060918 ! auxin transport intersection_of: occurs_in GO:0005622 ! intracellular created_by: donghui creation_date: 2010-09-23T03:46:29Z [Term] id: GO:0080163 name: regulation of protein serine/threonine phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142] synonym: "regulation of protein phosphatase type 2c activity" NARROW [] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity relationship: regulates GO:0004722 ! protein serine/threonine phosphatase activity created_by: donghui creation_date: 2010-09-23T03:51:37Z [Term] id: GO:0080164 name: regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: regulates GO:0046209 ! nitric oxide metabolic process created_by: donghui creation_date: 2010-09-23T04:02:50Z [Term] id: GO:0080165 name: callose deposition in phloem sieve plate namespace: biological_process def: "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [PMID:19470642] is_a: GO:0052545 ! callose localization created_by: donghui creation_date: 2010-09-23T04:12:49Z [Term] id: GO:0080166 name: stomium development namespace: biological_process def: "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048653 ! anther development created_by: donghui creation_date: 2010-09-23T05:03:40Z [Term] id: GO:0080167 name: response to karrikin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants)." [PMID:20351290] is_a: GO:0009628 ! response to abiotic stimulus created_by: donghui creation_date: 2010-09-23T05:07:22Z [Term] id: GO:0080168 name: abscisic acid transport namespace: biological_process def: "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:20133881] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0046865 ! terpenoid transport created_by: donghui creation_date: 2010-09-23T05:08:56Z [Term] id: GO:0080169 name: cellular response to boron-containing substance deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances." [PMID:20059736] synonym: "cellular response to boron deprivation" EXACT [] synonym: "cellular response to boron starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0062197 ! cellular response to chemical stress is_a: GO:0080029 ! cellular response to boron-containing substance levels created_by: donghui creation_date: 2010-09-23T05:10:00Z [Term] id: GO:0080170 name: hydrogen peroxide transmembrane transport namespace: biological_process def: "The process in which hydrogen peroxide is transported across a membrane." [GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hydrogen peroxide membrane transport" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0051181 ! cofactor transport created_by: donghui creation_date: 2010-09-23T05:12:14Z [Term] id: GO:0080171 name: lytic vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380] synonym: "lytic vacuolar assembly" NARROW [] synonym: "lytic vacuole biogenesis" RELATED [] synonym: "lytic vacuole organisation" EXACT [] synonym: "lytic vacuole organization and biogenesis" RELATED [] is_a: GO:0007033 ! vacuole organization created_by: donghui creation_date: 2011-04-25T04:40:46Z [Term] id: GO:0080172 name: petal epidermis patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis." [GOC:tb] is_a: GO:0003002 ! regionalization created_by: donghui creation_date: 2011-04-25T04:44:06Z [Term] id: GO:0080173 name: male-female gamete recognition during double fertilization forming a zygote and endosperm namespace: biological_process def: "The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana." [PMID:21123745] synonym: "gamete recognition" BROAD [] synonym: "male-female gamete recognition" EXACT [] is_a: GO:0009988 ! cell-cell recognition is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0061936 ! fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm created_by: donghui creation_date: 2011-04-26T04:58:58Z [Term] id: GO:0080175 name: phragmoplast microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells." [PMID:19383896] synonym: "phragmoplast microtubule cytoskeleton organization" EXACT [] synonym: "phragmoplast microtubule organisation" EXACT [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: occurs_in GO:0009524 ! phragmoplast relationship: occurs_in GO:0009524 ! phragmoplast created_by: donghui creation_date: 2011-04-28T03:54:11Z [Term] id: GO:0080176 name: xyloglucan 1,6-alpha-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus." [PMID:20801759] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: donghui creation_date: 2011-04-28T04:08:39Z [Term] id: GO:0080177 name: plastoglobule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [PMID:20813909] synonym: "plastoglobule organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0009658 ! chloroplast organization created_by: donghui creation_date: 2011-04-28T04:13:07Z [Term] id: GO:0080178 name: 5-carbamoylmethyl uridine residue modification namespace: biological_process def: "The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA." [GOC:dph, GOC:tb] synonym: "5-carbamoylmethyluridine metabolic process" RELATED [] is_a: GO:0030488 ! tRNA methylation created_by: donghui creation_date: 2011-04-28T04:36:23Z [Term] id: GO:0080179 name: 1-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-methylguanosine." [GOC:tb] is_a: GO:1901068 ! guanosine-containing compound metabolic process created_by: donghui creation_date: 2011-04-28T04:38:13Z [Term] id: GO:0080180 name: 2-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-methylguanosine." [GOC:tb] is_a: GO:1901068 ! guanosine-containing compound metabolic process created_by: donghui creation_date: 2011-04-28T04:41:01Z [Term] id: GO:0080181 name: lateral root branching namespace: biological_process def: "Any process involved in the formation of branches in lateral roots." [GOC:tb] is_a: GO:0001763 ! morphogenesis of a branching structure relationship: part_of GO:0010102 ! lateral root morphogenesis created_by: donghui creation_date: 2011-08-10T04:13:33Z [Term] id: GO:0080182 name: histone H3-K4 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone." [GOC:BHF, GOC:se, GOC:tb] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0051568 ! histone H3-K4 methylation created_by: donghui creation_date: 2011-08-10T04:18:36Z [Term] id: GO:0080183 name: response to photooxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [DOI:10.1111/j.1399-3054.1994.tb03042.x] is_a: GO:0006979 ! response to oxidative stress created_by: donghui creation_date: 2011-08-10T04:26:11Z [Term] id: GO:0080184 name: response to phenylpropanoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin." [CHEBI:26004, GOC:tb] is_a: GO:0014070 ! response to organic cyclic compound created_by: donghui creation_date: 2011-08-10T04:28:21Z [Term] id: GO:0080185 name: effector-triggered induction of plant hypersensitive response by symbiont namespace: biological_process alt_id: GO:0052101 alt_id: GO:0052286 alt_id: GO:0052423 alt_id: GO:0052527 def: "A symbiont process whereby a molecule secreted by the symbiont activates plant effector-triggered immunity (ETI) signalling and the subsequent activation of a plant hypersensitive response to induce necrosis. In the plant, ETI involves the direct or indirect recognition of an effector protein by the host. for example through plant resistance receptor or R proteins." [PMID:16497589, PMID:22241993, PMID:23411798, PMID:27641772, Wikipedia:Effector-triggered_immunity] comment: Note that this term should probably be only used to annotate plant pathogens. Evidence of direct recognition of pathogen effectors in animals is currently lacking, see PMID:23411798. synonym: "activation by organism of defense response in host by specific elicitors" BROAD [] synonym: "activation by organism of host gene-for-gene resistance" EXACT [] synonym: "activation by organism of host resistance gene-dependent defense response" EXACT [] synonym: "activation by symbiont of host resistance gene-dependent defense response" EXACT [] synonym: "effector-triggered induction of host innate immune response" EXACT [] synonym: "effector-triggered necrosis" EXACT [PMID:27641772] synonym: "ETI triggered of host innate immune response" EXACT [] synonym: "ETI-triggered of host innate immune response" EXACT [] synonym: "induction by organism of defense response in host by specific elicitors" BROAD [] synonym: "induction by organism of host gene-for-gene resistance" EXACT [] synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" BROAD [] synonym: "induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [] synonym: "induction by symbiont of host resistance gene-dependent defense response" EXACT [] synonym: "induction of effector-triggered immunity (ETI)" EXACT [] synonym: "positive regulation by organism of defense response in host by specific elicitors" BROAD [] synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT [] synonym: "positive regulation by symbiont of host resistance gene-dependent defense response" RELATED [] is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response is_a: GO:0052390 ! induction by symbiont of host innate immune response is_a: GO:0140404 ! effector-mediated modulation of host immune response by symbiont created_by: donghui creation_date: 2011-08-10T04:33:53Z [Term] id: GO:0080186 name: developmental vegetative growth namespace: biological_process def: "The increase in size or mass of non-reproductive plant parts." [PO:0007134] is_a: GO:0048589 ! developmental growth created_by: donghui creation_date: 2011-08-17T03:45:53Z [Term] id: GO:0080187 name: floral organ senescence namespace: biological_process def: "An organ senescence that has as a participant a floral organ." [PMID:21689171, PO:0025395] comment: Includes senescence of petals, sepals, anthers, and any other plant organ that is part of a flower. Floral organ senescence may follow pollination. In some flowers, the organs of the corolla abscise before they senesce. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090693 ! plant organ senescence relationship: part_of GO:0048437 ! floral organ development created_by: donghui creation_date: 2012-03-09T04:08:50Z [Term] id: GO:0080188 name: RNA-directed DNA methylation namespace: biological_process def: "An epigenetic RNA-based gene silencing process first elucidated in plants whereby 24-nt small interfering RNAs (siRNAs) guide DNA methyltransferases to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci." [PMID:21420348] synonym: "RdDM" EXACT [] is_a: GO:0006306 ! DNA methylation is_a: GO:0031047 ! gene silencing by RNA created_by: donghui creation_date: 2012-05-22T02:22:50Z [Term] id: GO:0080189 name: primary growth namespace: biological_process def: "Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed." [ISBN:0471245208] comment: Has its inception in the apical meristems (PO:0020144) and continues in their derivative meristems - protoderm (PO:0006210) and procambium (PO:0025275) - even in older tissues. Primary and secondary growth can occur simultaneously in the same organism. is_a: GO:0032501 ! multicellular organismal process is_a: GO:0040007 ! growth created_by: donghui creation_date: 2012-12-06T15:20:41Z [Term] id: GO:0080190 name: lateral growth namespace: biological_process def: "Growth of a plant axis (shoot axis or root) that originates from a lateral meristem." [PO:0020145] comment: Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons. is_a: GO:0040007 ! growth created_by: donghui creation_date: 2012-12-06T15:42:28Z [Term] id: GO:0080191 name: secondary thickening namespace: biological_process def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem." [JSTOR:4354165, PO:0025004, PO:0025414] comment: Occurs in shoot axes in some monocotyledons such as Dracaena, and rarely in roots of monocotyledons. Distinct from primary thickening, because it is distant from and generally discontinuous with the apical meristem. is_a: GO:0080190 ! lateral growth created_by: donghui creation_date: 2012-12-06T15:50:33Z [Term] id: GO:0080192 name: primary thickening namespace: biological_process def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem." [ISBN:0471245208, JSTOR:4354165, PO:0005039, PO:0025004] comment: Occurs in shoot axes and rarely in roots in many monocotyledons. is_a: GO:0080190 ! lateral growth created_by: donghui creation_date: 2012-12-06T15:55:18Z [Term] id: GO:0080193 name: diffuse secondary thickening namespace: biological_process def: "Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem." [GOC:dhl] comment: Occurs in the stems (PO:0009047) of some Arecaceae (palms). is_a: GO:0080190 ! lateral growth created_by: donghui creation_date: 2012-12-06T15:57:50Z [Term] id: GO:0085000 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type V secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-07-09T03:08:54Z [Term] id: GO:0085001 name: formation by symbiont of stylet for nutrient acquisition from host namespace: biological_process def: "The assembly by a symbiont of a stylet, a hollow protrusible spear-like structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host created_by: jane creation_date: 2010-02-24T01:49:06Z [Term] id: GO:0085002 name: obsolete interaction with host mediated by secreted substance released by symbiont from symbiotic structure namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T02:38:10Z [Term] id: GO:0085003 name: obsolete interaction with host via secreted substance released from stylet namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T02:53:56Z [Term] id: GO:0085004 name: obsolete interaction with host via secreted substance released from haustorium namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T02:58:39Z [Term] id: GO:0085005 name: obsolete interaction with host via secreted substance released from invasive hyphae namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T02:59:51Z [Term] id: GO:0085006 name: obsolete interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-02-10T03:00:56Z [Term] id: GO:0085007 name: obsolete interaction with host via secreted substance released from rhoptry namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secreaton system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T03:02:08Z [Term] id: GO:0085008 name: obsolete interaction with host via secreted substance released from microneme namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T03:03:16Z [Term] id: GO:0085009 name: obsolete interaction with host mediated by symbiont secreted substance released from Maurer's cleft namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-02-10T03:08:39Z [Term] id: GO:0085010 name: obsolete interaction with host mediated by secreted substance entering host via endocytosis namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T03:12:31Z [Term] id: GO:0085011 name: obsolete interaction with host via protein secreted by Sec complex namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with host via protein secreted by Sec secretion system" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-02-10T03:18:36Z [Term] id: GO:0085012 name: obsolete interaction with host via protein secreted by Tat complex namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "interaction with host via protein secreted by Tat secretion system" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-02-10T03:29:37Z [Term] id: GO:0085013 name: obsolete interaction with host via protein secreted by type VII secretion system namespace: biological_process def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-02-10T03:31:07Z [Term] id: GO:0085014 name: dormancy entry of symbiont in host namespace: biological_process def: "Entry into a dormant state of the symbiont within the host organism." [GOC:jl] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2010-05-19T02:33:26Z [Term] id: GO:0085015 name: dormancy maintenance of symbiont in host namespace: biological_process def: "Any process in which a dormant state is maintained by the symbiont within the host organism." [GOC:jl] synonym: "non-replicating persistence" EXACT [] synonym: "NRP" EXACT [] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2010-05-19T03:17:32Z [Term] id: GO:0085016 name: dormancy exit of symbiont in host namespace: biological_process def: "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism." [GOC:jl] synonym: "resuscitation of symbiont" EXACT [] is_a: GO:0022611 ! dormancy process is_a: GO:0044114 ! development of symbiont in host created_by: jane creation_date: 2010-05-19T03:23:07Z [Term] id: GO:0085017 name: entry into host cell by a symbiont-containing vacuole namespace: biological_process def: "The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole." [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555] synonym: "symbiont entry into host cell forming a parasitophorous vacuole" EXACT [] synonym: "symbiont entry into host cell forming a pathogen-containing vacuole" EXACT [] synonym: "symbiont entry into host cell forming a symbiont-containing vacuole" RELATED [] is_a: GO:0030260 ! entry into host cell created_by: jane creation_date: 2010-05-20T02:55:34Z [Term] id: GO:0085018 name: maintenance of symbiont-containing vacuole by host namespace: biological_process def: "The process in which a host organism maintains the structure and function of a symbiont-containing vacuole. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides, and can serve to reduce pathogenicity of invading symbionts by restricting them to the vacuolar compartment." [GOC:jl, GOC:yaf, PMID:18665841] synonym: "maintenance of parasitophorous vacuole" EXACT [] synonym: "maintenance of pathogen-containing vacuole" EXACT [] synonym: "maintenance of vacuolar integrity during bacterial infection" NARROW [] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology created_by: jane creation_date: 2010-05-20T03:58:51Z [Term] id: GO:0085019 name: formation by symbiont of a tubovesicular network for nutrient acquisition from host namespace: biological_process def: "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "formation of a symbiont- induced tubovesicular network for nutrient acquisition from host" EXACT [] is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host created_by: jane creation_date: 2010-05-20T04:29:24Z [Term] id: GO:0085020 name: protein K6-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp] synonym: "protein K6-linked polyubiquitination" EXACT [GOC:mah] is_a: GO:0000209 ! protein polyubiquitination created_by: jane creation_date: 2010-06-01T03:05:03Z [Term] id: GO:0085021 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type I secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-07-09T03:20:44Z [Term] id: GO:0085022 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-07-09T03:32:02Z [Term] id: GO:0085023 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system namespace: biological_process def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. is_obsolete: true created_by: jane creation_date: 2010-07-09T03:35:02Z [Term] id: GO:0085024 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Sec complex namespace: biological_process def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-07-09T03:44:31Z [Term] id: GO:0085025 name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Tat complex namespace: biological_process def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system" EXACT [] is_obsolete: true created_by: jane creation_date: 2010-07-09T03:47:01Z [Term] id: GO:0085026 name: tubovesicular membrane network namespace: cellular_component def: "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains." [GOC:pamgo_curators] synonym: "TVM network" EXACT [] synonym: "TVN" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0043264 ! extracellular non-membrane-bounded organelle created_by: jane creation_date: 2010-07-09T03:55:41Z [Term] id: GO:0085027 name: entry into host via enzymatic degradation of host anatomical structure namespace: biological_process def: "Penetration by symbiont of a host anatomical structure which provides a barrier to symbiont entry, mediated by symbiont degradative enzymes." [GOC:pamgo_curators] is_a: GO:0044409 ! entry into host created_by: jane creation_date: 2010-07-09T04:00:22Z [Term] id: GO:0085028 name: entry into host via enzymatic degradation of host cuticle namespace: biological_process def: "Penetration by symbiont of host physical barriers, mediated by symbiont degradative enzymes." [GOC:pamgo_curators] is_a: GO:0085027 ! entry into host via enzymatic degradation of host anatomical structure created_by: jane creation_date: 2010-07-09T04:02:41Z [Term] id: GO:0085029 name: extracellular matrix assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030198 ! extracellular matrix organization created_by: jane creation_date: 2010-07-14T12:52:49Z [Term] id: GO:0085030 name: symbiotic process benefiting host namespace: biological_process def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt] synonym: "mutualism" RELATED [] is_a: GO:0044403 ! symbiotic process created_by: janelomax creation_date: 2010-07-27T01:25:21Z [Term] id: GO:0085032 name: modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway created_by: janelomax creation_date: 2010-07-27T02:13:37Z [Term] id: GO:0085033 name: induction by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "induction by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] synonym: "positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway" EXACT [] synonym: "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] synonym: "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:0085032 ! modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade created_by: janelomax creation_date: 2010-07-27T02:47:01Z [Term] id: GO:0085034 name: suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway created_by: janelomax creation_date: 2010-07-27T03:32:44Z [Term] id: GO:0085035 name: haustorium namespace: cellular_component def: "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane." [GOC:pamgo_curators] comment: See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037. is_a: GO:0042995 ! cell projection created_by: janelomax creation_date: 2010-07-27T03:42:24Z [Term] id: GO:0085036 name: extrahaustorial matrix namespace: cellular_component def: "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host." [GOC:pamgo_curators] comment: See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region relationship: part_of GO:0043655 ! host extracellular space created_by: janelomax creation_date: 2010-07-27T03:58:20Z [Term] id: GO:0085037 name: extrahaustorial membrane namespace: cellular_component def: "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane." [GOC:pamgo_curators] comment: See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036. is_a: GO:0033644 ! host cell membrane relationship: part_of GO:0020002 ! host cell plasma membrane created_by: janelomax creation_date: 2010-07-27T04:00:49Z [Term] id: GO:0085039 name: extra-invasive hyphal membrane namespace: cellular_component def: "A host-derived membrane surrounding the symbiont invasive hypha during symbiosis." [GOC:pamgo_curators] comment: See also: extra-invasive hyphal space ; GO:0085040. is_a: GO:0033644 ! host cell membrane created_by: janelomax creation_date: 2010-07-27T04:19:46Z [Term] id: GO:0085040 name: extra-invasive hyphal space namespace: cellular_component def: "The space between the symbiont plasma membrane and the extra-invasive hyphal membrane." [GOC:pamgo_curators] comment: See also: 'extra-invasive hyphal membrane ; GO:0085039'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005576 ! extracellular region relationship: part_of GO:0043655 ! host extracellular space created_by: janelomax creation_date: 2010-07-27T04:21:26Z [Term] id: GO:0085041 name: arbuscule namespace: cellular_component def: "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange." [GOC:pamgo_curators] comment: See also: periarbuscular membrane ; GO:0085042. is_a: GO:0085035 ! haustorium created_by: janelomax creation_date: 2010-07-27T04:29:03Z [Term] id: GO:0085042 name: periarbuscular membrane namespace: cellular_component def: "A host-derived membrane surrounding the symbiont arbuscule during symbiosis." [GOC:pamgo_curators] comment: See also: arbuscule ; GO:0085041. is_a: GO:0033644 ! host cell membrane created_by: janelomax creation_date: 2010-07-27T04:31:37Z [Term] id: GO:0085044 name: disassembly by symbiont of host cuticle namespace: biological_process def: "The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] synonym: "catabolism of host cuticle" EXACT [] synonym: "degradation of host cuticle" RELATED [] is_a: GO:0052111 ! modification by symbiont of host structure created_by: janelomax creation_date: 2010-07-27T01:08:15Z [Term] id: GO:0086001 name: cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0001508 ! action potential created_by: tanyaberardini creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086002 name: cardiac muscle cell action potential involved in contraction namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell and is involved in its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0086001 ! cardiac muscle cell action potential intersection_of: part_of GO:0086003 ! cardiac muscle cell contraction relationship: part_of GO:0086003 ! cardiac muscle cell contraction created_by: tanyaberardini creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086003 name: cardiac muscle cell contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0060048 ! cardiac muscle contraction created_by: tanyaberardini creation_date: 2011-11-10T07:48:15Z [Term] id: GO:0086004 name: regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0055117 ! regulation of cardiac muscle contraction is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086003 ! cardiac muscle cell contraction relationship: regulates GO:0086003 ! cardiac muscle cell contraction created_by: tanyaberardini creation_date: 2011-11-10T07:49:10Z [Term] id: GO:0086005 name: ventricular cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction created_by: tanyaberardini creation_date: 2011-11-10T07:59:36Z [Term] id: GO:0086006 name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005248 ! voltage-gated sodium channel activity intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential relationship: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:34:49Z [Term] id: GO:0086007 name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005245 ! voltage-gated calcium channel activity intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential relationship: part_of GO:0086012 ! membrane depolarization during cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:04:42Z [Term] id: GO:0086008 name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005249 ! voltage-gated potassium channel activity intersection_of: GO:0005249 ! voltage-gated potassium channel activity intersection_of: part_of GO:0086013 ! membrane repolarization during cardiac muscle cell action potential relationship: part_of GO:0086013 ! membrane repolarization during cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:38:09Z [Term] id: GO:0086009 name: membrane repolarization namespace: biological_process def: "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0034220 ! ion transmembrane transport is_a: GO:0042391 ! regulation of membrane potential created_by: tanyaberardini creation_date: 2011-11-10T08:13:18Z [Term] id: GO:0086010 name: membrane depolarization during action potential namespace: biological_process def: "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0051899 ! membrane depolarization intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0001508 ! action potential relationship: part_of GO:0001508 ! action potential created_by: tanyaberardini creation_date: 2011-11-10T08:15:05Z [Term] id: GO:0086011 name: membrane repolarization during action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086009 ! membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0001508 ! action potential relationship: part_of GO:0001508 ! action potential created_by: tanyaberardini creation_date: 2011-11-10T08:15:05Z [Term] id: GO:0086012 name: membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086010 ! membrane depolarization during action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086001 ! cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:20:33Z [Term] id: GO:0086013 name: membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086011 ! membrane repolarization during action potential is_a: GO:0099622 ! cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086001 ! cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:23:25Z [Term] id: GO:0086014 name: atrial cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in an atrial cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction relationship: part_of GO:0086026 ! atrial cardiac muscle cell to AV node cell signaling created_by: tanyaberardini creation_date: 2011-11-10T08:49:13Z [Term] id: GO:0086015 name: SA node cell action potential namespace: biological_process def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell action potential" EXACT [] synonym: "SAN cardiac muscle cell action potential" EXACT [] synonym: "sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signaling created_by: tanyaberardini creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0086016 name: AV node cell action potential namespace: biological_process def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling created_by: tanyaberardini creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086017 name: Purkinje myocyte action potential namespace: biological_process def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling created_by: tanyaberardini creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086018 name: SA node cell to atrial cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW [] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication created_by: tanyaberardini creation_date: 2011-11-10T09:15:01Z [Term] id: GO:0086019 name: cell-cell signaling involved in cardiac conduction namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0086065 ! cell communication involved in cardiac conduction intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-16T03:43:52Z [Term] id: GO:0086020 name: gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling" EXACT [] synonym: "gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling" EXACT [] synonym: "gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling" EXACT [] synonym: "gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling" NARROW [] is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086021 ! SA node cell to atrial cardiac muscle cell communication by electrical coupling relationship: part_of GO:0086021 ! SA node cell to atrial cardiac muscle cell communication by electrical coupling created_by: tanyaberardini creation_date: 2011-11-11T02:08:19Z [Term] id: GO:0086021 name: SA node cell to atrial cardiac muscle cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" NARROW [] is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication created_by: tanyaberardini creation_date: 2011-11-10T09:20:39Z [Term] id: GO:0086022 name: SA node cell-atrial cardiac muscle cell adhesion involved in cell communication namespace: biological_process def: "The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication" EXACT [] synonym: "SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] synonym: "SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] synonym: "sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] synonym: "sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" NARROW [] is_a: GO:0034113 ! heterotypic cell-cell adhesion is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion relationship: part_of GO:0086070 ! SA node cell to atrial cardiac muscle cell communication created_by: tanyaberardini creation_date: 2011-11-10T09:26:52Z [Term] id: GO:0086023 name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "A series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "adrenergic receptor signaling pathway involved in heart process" EXACT [] synonym: "adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:bf] is_a: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: tanyaberardini creation_date: 2011-11-11T02:51:03Z [Term] id: GO:0086024 name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate namespace: biological_process def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118] synonym: "activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] synonym: "adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] synonym: "adrenergic receptor signaling pathway involved in positive regulation of heart rate" BROAD [] synonym: "adrenergic receptor signalling pathway involved in positive regulation of heart rate" BROAD [GOC:bf] synonym: "beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:mtg_cardiac_conduct_nov11] synonym: "Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:mtg_cardiac_conduct_nov11] synonym: "If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine is_a: GO:0140200 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate intersection_of: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway intersection_of: part_of GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0010460 ! positive regulation of heart rate created_by: tanyaberardini creation_date: 2011-11-10T09:38:49Z [Term] id: GO:0086026 name: atrial cardiac muscle cell to AV node cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte to atrioventricular node cell signaling" EXACT [] synonym: "atrial cardiomyocyte to AV node cell signaling" EXACT [] synonym: "atrial cardiomyocyte to AV node cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication created_by: tanyaberardini creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086027 name: AV node cell to bundle of His cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node to bundle of His cell signaling" EXACT [] synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086067 ! AV node cell to bundle of His cell communication created_by: tanyaberardini creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086028 name: bundle of His cell to Purkinje myocyte signaling namespace: biological_process def: "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signaling" EXACT [] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication created_by: tanyaberardini creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086029 name: Purkinje myocyte to ventricular cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication created_by: tanyaberardini creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086030 name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation namespace: biological_process def: "An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541] synonym: "adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11] synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [] synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED [GOC:mtg_cardiac_conduct_nov11] synonym: "adrenergic receptor-induced cardiac relaxation" RELATED [PMID:10571541] synonym: "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway intersection_of: part_of GO:0055119 ! relaxation of cardiac muscle relationship: part_of GO:0055119 ! relaxation of cardiac muscle created_by: tanyaberardini creation_date: 2011-11-11T02:53:24Z [Term] id: GO:0086033 name: G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] synonym: "M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT [] is_a: GO:0086093 ! G protein-coupled acetylcholine receptor signaling pathway involved in heart process intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: part_of GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003063 ! negative regulation of heart rate by acetylcholine created_by: tanyaberardini creation_date: 2011-11-11T03:11:58Z [Term] id: GO:0086036 name: regulation of cardiac muscle cell membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0042391 ! regulation of membrane potential created_by: tanyaberardini creation_date: 2011-11-11T03:23:36Z [Term] id: GO:0086037 name: sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005391 ! sodium:potassium-exchanging ATPase activity intersection_of: GO:0005391 ! sodium:potassium-exchanging ATPase activity intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential created_by: tanyaberardini creation_date: 2011-11-11T03:33:44Z [Term] id: GO:0086038 name: calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005432 ! calcium:sodium antiporter activity intersection_of: GO:0005432 ! calcium:sodium antiporter activity intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential created_by: tanyaberardini creation_date: 2011-11-11T03:33:44Z [Term] id: GO:0086039 name: calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential created_by: tanyaberardini creation_date: 2011-11-11T03:33:44Z [Term] id: GO:0086040 name: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential" EXACT [] is_a: GO:0015385 ! sodium:proton antiporter activity intersection_of: GO:0015385 ! sodium:proton antiporter activity intersection_of: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential relationship: part_of GO:0086036 ! regulation of cardiac muscle cell membrane potential created_by: tanyaberardini creation_date: 2011-11-11T03:33:44Z [Term] id: GO:0086041 name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in SAN cell action potential depolarization" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization" NARROW [] is_a: GO:0005249 ! voltage-gated potassium channel activity intersection_of: GO:0005267 ! potassium channel activity intersection_of: part_of GO:0086046 ! membrane depolarization during SA node cell action potential relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential created_by: tanyaberardini creation_date: 2011-11-11T03:37:42Z [Term] id: GO:0086042 name: cardiac muscle cell-cardiac muscle cell adhesion namespace: biological_process def: "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cardiomyocyte-cardiomyocyte adhesion" EXACT [] is_a: GO:0034109 ! homotypic cell-cell adhesion created_by: tanyaberardini creation_date: 2011-11-11T04:06:25Z [Term] id: GO:0086043 name: bundle of His cell action potential namespace: biological_process def: "An action potential that occurs in a bundle of His cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086028 ! bundle of His cell to Purkinje myocyte signaling created_by: dph creation_date: 2011-11-15T12:01:18Z [Term] id: GO:0086044 name: atrial cardiac muscle cell to AV node cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling" EXACT [] synonym: "atrial cardiomyocyte to AV node cell communication by electrical coupling" EXACT [] is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication created_by: dph creation_date: 2011-11-15T02:51:29Z [Term] id: GO:0086045 name: membrane depolarization during AV node cell action potential namespace: biological_process def: "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization during AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086016 ! AV node cell action potential relationship: part_of GO:0086016 ! AV node cell action potential created_by: dph creation_date: 2011-11-16T10:45:18Z [Term] id: GO:0086046 name: membrane depolarization during SA node cell action potential namespace: biological_process def: "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086015 ! SA node cell action potential relationship: part_of GO:0086015 ! SA node cell action potential created_by: dph creation_date: 2011-11-16T10:52:57Z [Term] id: GO:0086047 name: membrane depolarization during Purkinje myocyte cell action potential namespace: biological_process def: "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential relationship: part_of GO:0086017 ! Purkinje myocyte action potential created_by: dph creation_date: 2011-11-16T10:54:47Z [Term] id: GO:0086048 name: membrane depolarization during bundle of His cell action potential namespace: biological_process def: "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane depolarization during bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086043 ! bundle of His cell action potential relationship: part_of GO:0086043 ! bundle of His cell action potential created_by: dph creation_date: 2011-11-16T10:56:26Z [Term] id: GO:0086049 name: membrane repolarization during AV node cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086016 ! AV node cell action potential relationship: part_of GO:0086016 ! AV node cell action potential created_by: dph creation_date: 2011-11-16T11:43:38Z [Term] id: GO:0086050 name: membrane repolarization during bundle of His cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization during bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086043 ! bundle of His cell action potential relationship: part_of GO:0086043 ! bundle of His cell action potential created_by: dph creation_date: 2011-11-16T11:50:41Z [Term] id: GO:0086051 name: membrane repolarization during Purkinje myocyte action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential relationship: part_of GO:0086017 ! Purkinje myocyte action potential created_by: dph creation_date: 2011-11-16T11:51:56Z [Term] id: GO:0086052 name: membrane repolarization during SA node cell action potential namespace: biological_process def: "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086015 ! SA node cell action potential relationship: part_of GO:0086015 ! SA node cell action potential created_by: dph creation_date: 2011-11-16T11:54:12Z [Term] id: GO:0086053 name: AV node cell to bundle of His cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell to bundle of His cell communication by electrical coupling" EXACT [] is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction is_a: GO:0086067 ! AV node cell to bundle of His cell communication created_by: dph creation_date: 2011-11-16T12:31:08Z [Term] id: GO:0086054 name: bundle of His cell to Purkinje myocyte communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling" EXACT [] is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication created_by: dph creation_date: 2011-11-17T10:46:43Z [Term] id: GO:0086055 name: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication created_by: dph creation_date: 2011-11-17T10:51:59Z [Term] id: GO:0086056 name: voltage-gated calcium channel activity involved in AV node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0086016 ! AV node cell action potential relationship: part_of GO:0086045 ! membrane depolarization during AV node cell action potential created_by: dph creation_date: 2011-11-17T12:24:22Z [Term] id: GO:0086057 name: voltage-gated calcium channel activity involved in bundle of His cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0086043 ! bundle of His cell action potential relationship: part_of GO:0086048 ! membrane depolarization during bundle of His cell action potential created_by: dph creation_date: 2011-11-17T12:32:51Z [Term] id: GO:0086058 name: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential relationship: part_of GO:0086047 ! membrane depolarization during Purkinje myocyte cell action potential created_by: dph creation_date: 2011-11-17T12:35:02Z [Term] id: GO:0086059 name: voltage-gated calcium channel activity involved SA node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0086015 ! SA node cell action potential relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential created_by: dph creation_date: 2011-11-17T12:39:27Z [Term] id: GO:0086060 name: voltage-gated sodium channel activity involved in AV node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: part_of GO:0086016 ! AV node cell action potential relationship: part_of GO:0086045 ! membrane depolarization during AV node cell action potential created_by: dph creation_date: 2011-11-17T12:52:48Z [Term] id: GO:0086061 name: voltage-gated sodium channel activity involved in bundle of His cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: part_of GO:0086043 ! bundle of His cell action potential relationship: part_of GO:0086048 ! membrane depolarization during bundle of His cell action potential created_by: dph creation_date: 2011-11-17T12:58:13Z [Term] id: GO:0086062 name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: part_of GO:0086017 ! Purkinje myocyte action potential relationship: part_of GO:0086047 ! membrane depolarization during Purkinje myocyte cell action potential created_by: dph creation_date: 2011-11-17T01:50:43Z [Term] id: GO:0086063 name: voltage-gated sodium channel activity involved in SA node cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: part_of GO:0086015 ! SA node cell action potential relationship: part_of GO:0086046 ! membrane depolarization during SA node cell action potential created_by: dph creation_date: 2011-11-17T01:53:08Z [Term] id: GO:0086064 name: cell communication by electrical coupling involved in cardiac conduction namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010644 ! cell communication by electrical coupling is_a: GO:0086065 ! cell communication involved in cardiac conduction intersection_of: GO:0010644 ! cell communication by electrical coupling intersection_of: part_of GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-22T08:49:44Z [Term] id: GO:0086065 name: cell communication involved in cardiac conduction namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007154 ! cell communication intersection_of: GO:0007154 ! cell communication intersection_of: part_of GO:0061337 ! cardiac conduction relationship: part_of GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-22T08:57:02Z [Term] id: GO:0086066 name: atrial cardiac muscle cell to AV node cell communication namespace: biological_process def: "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte to atrioventricular node cell communication" EXACT [] synonym: "atrial cardiomyocyte to AV node cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:05:09Z [Term] id: GO:0086067 name: AV node cell to bundle of His cell communication namespace: biological_process def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell to bundle of His cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:11:44Z [Term] id: GO:0086068 name: Purkinje myocyte to ventricular cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:14:49Z [Term] id: GO:0086069 name: bundle of His cell to Purkinje myocyte communication namespace: biological_process def: "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:18:49Z [Term] id: GO:0086070 name: SA node cell to atrial cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW [] is_a: GO:0086065 ! cell communication involved in cardiac conduction created_by: dph creation_date: 2011-11-22T09:32:45Z [Term] id: GO:0086071 name: atrial cardiac muscle cell-AV node cell adhesion involved in cell communication namespace: biological_process def: "The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication" EXACT [] synonym: "atrial cardiomyocyte-AV node cell adhesion involved in cell communication" EXACT [] is_a: GO:0034113 ! heterotypic cell-cell adhesion is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion intersection_of: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion intersection_of: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication relationship: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication created_by: dph creation_date: 2011-11-22T09:46:33Z [Term] id: GO:0086072 name: AV node cell-bundle of His cell adhesion involved in cell communication namespace: biological_process def: "The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell-bundle of His cell adhesion involved in cell communication" EXACT [] is_a: GO:0034113 ! heterotypic cell-cell adhesion is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion relationship: part_of GO:0086067 ! AV node cell to bundle of His cell communication created_by: dph creation_date: 2011-11-22T09:49:59Z [Term] id: GO:0086073 name: bundle of His cell-Purkinje myocyte adhesion involved in cell communication namespace: biological_process def: "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0034113 ! heterotypic cell-cell adhesion is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion relationship: part_of GO:0086069 ! bundle of His cell to Purkinje myocyte communication created_by: dph creation_date: 2011-11-22T10:00:30Z [Term] id: GO:0086074 name: Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication namespace: biological_process def: "The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0034113 ! heterotypic cell-cell adhesion is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion relationship: part_of GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication created_by: dph creation_date: 2011-11-22T10:02:24Z [Term] id: GO:0086075 name: gap junction channel activity involved in cardiac conduction electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:1903763 ! gap junction channel activity involved in cell communication by electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction relationship: part_of GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction created_by: dph creation_date: 2011-11-22T10:08:29Z [Term] id: GO:0086076 name: gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling" EXACT [] synonym: "gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling" RELATED [] is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086044 ! atrial cardiac muscle cell to AV node cell communication by electrical coupling relationship: part_of GO:0086044 ! atrial cardiac muscle cell to AV node cell communication by electrical coupling created_by: dph creation_date: 2011-11-22T10:26:27Z [Term] id: GO:0086077 name: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling" EXACT [] is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086053 ! AV node cell to bundle of His cell communication by electrical coupling relationship: part_of GO:0086053 ! AV node cell to bundle of His cell communication by electrical coupling created_by: dph creation_date: 2011-11-22T10:29:53Z [Term] id: GO:0086078 name: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086054 ! bundle of His cell to Purkinje myocyte communication by electrical coupling relationship: part_of GO:0086054 ! bundle of His cell to Purkinje myocyte communication by electrical coupling created_by: dph creation_date: 2011-11-22T10:34:13Z [Term] id: GO:0086079 name: gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling namespace: molecular_function def: "A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0086055 ! Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling relationship: part_of GO:0086055 ! Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling created_by: dph creation_date: 2011-11-22T10:36:23Z [Term] id: GO:0086080 name: protein binding involved in heterotypic cell-cell adhesion namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098632 ! cell-cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: part_of GO:0034113 ! heterotypic cell-cell adhesion relationship: part_of GO:0034113 ! heterotypic cell-cell adhesion created_by: dph creation_date: 2011-11-22T10:53:52Z [Term] id: GO:0086081 name: cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication" EXACT [] synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication" EXACT [] is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: part_of GO:0086071 ! atrial cardiac muscle cell-AV node cell adhesion involved in cell communication relationship: part_of GO:0086071 ! atrial cardiac muscle cell-AV node cell adhesion involved in cell communication created_by: dph creation_date: 2011-11-22T11:00:47Z [Term] id: GO:0086082 name: cell adhesive protein binding involved in AV node cell-bundle of His cell communication namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication" EXACT [] is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: part_of GO:0086072 ! AV node cell-bundle of His cell adhesion involved in cell communication relationship: part_of GO:0086072 ! AV node cell-bundle of His cell adhesion involved in cell communication created_by: dph creation_date: 2011-11-22T11:09:37Z [Term] id: GO:0086083 name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: part_of GO:0086073 ! bundle of His cell-Purkinje myocyte adhesion involved in cell communication relationship: part_of GO:0086073 ! bundle of His cell-Purkinje myocyte adhesion involved in cell communication created_by: dph creation_date: 2011-11-22T11:11:03Z [Term] id: GO:0086084 name: cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: part_of GO:0086074 ! Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication relationship: part_of GO:0086074 ! Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication created_by: dph creation_date: 2011-11-22T11:13:16Z [Term] id: GO:0086085 name: cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication" EXACT [] is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion intersection_of: part_of GO:0086022 ! SA node cell-atrial cardiac muscle cell adhesion involved in cell communication relationship: part_of GO:0086022 ! SA node cell-atrial cardiac muscle cell adhesion involved in cell communication created_by: dph creation_date: 2011-11-22T11:15:07Z [Term] id: GO:0086086 name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization" EXACT [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0086049 ! membrane repolarization during AV node cell action potential created_by: dph creation_date: 2011-11-22T01:26:32Z [Term] id: GO:0086087 name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0086050 ! membrane repolarization during bundle of His cell action potential created_by: dph creation_date: 2011-11-22T01:30:20Z [Term] id: GO:0086088 name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0086051 ! membrane repolarization during Purkinje myocyte action potential created_by: dph creation_date: 2011-11-22T01:32:02Z [Term] id: GO:0086089 name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential created_by: dph creation_date: 2011-11-22T01:33:01Z [Term] id: GO:0086090 name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "voltage-gated potassium channel activity involved in SAN cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential" EXACT [] synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential" NARROW [] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0086052 ! membrane repolarization during SA node cell action potential created_by: dph creation_date: 2011-11-22T01:38:08Z [Term] id: GO:0086091 name: regulation of heart rate by cardiac conduction namespace: biological_process def: "A cardiac conduction process that modulates the frequency or rate of heart contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-29T01:04:19Z [Term] id: GO:0086092 name: regulation of the force of heart contraction by cardiac conduction namespace: biological_process def: "A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0002026 ! regulation of the force of heart contraction is_a: GO:0061337 ! cardiac conduction created_by: dph creation_date: 2011-11-29T01:26:41Z [Term] id: GO:0086093 name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT [] synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: rfoulger [Term] id: GO:0086094 name: positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction namespace: biological_process def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118] synonym: "adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation" NARROW [PMID:21099118] is_a: GO:0140200 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate relationship: part_of GO:0060452 ! positive regulation of cardiac muscle contraction created_by: rfoulger [Term] id: GO:0086095 name: positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel] synonym: "cardiac muscarinic receptor signaling via Gbeta/gamma" RELATED [GOC:mtg_cardiac_conduct_nov11] synonym: "Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signaling pathway involved in activation of IKACH" EXACT [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signaling pathway involved in ion channel activation" BROAD [GOC:mtg_cardiac_conduct_nov11] synonym: "positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling" EXACT [] is_a: GO:0086033 ! G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate is_a: GO:1900129 ! positive regulation of G-protein activated inward rectifier potassium channel activity intersection_of: GO:0086033 ! G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate intersection_of: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity created_by: rfoulger [Term] id: GO:0086096 name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "An adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart, where the activated adrenergic receptor transmits the signal by Gi-mediated inhibition of adenylate cyclase activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541] comment: Although Beta1-adrenergic receptors couple exclusively to the Gs protein, Beta2-adrenergic receptors couple to both Gs and Gi proteins. Coupling to Gi proteins may localize the Gs-mediated signaling. synonym: "cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:bf] synonym: "G-inhibitory-coupled Beta2AR signaling pathway involved in heart process" EXACT [PMID:17376402] synonym: "Gi-coupled adrenergic receptor signaling pathway involved in heart process" EXACT [PMID:10571541] synonym: "Gi-coupled Beta2-AR signaling pathway involved in heart process" EXACT [PMID:10571541] is_a: GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: rfoulger [Term] id: GO:0086097 name: phospholipase C-activating angiotensin-activated signaling pathway namespace: biological_process def: "An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "angiotensin-mediated signaling pathway via activation of phospholipase C" EXACT [GOC:bf] synonym: "Gq-coupled angiotensin receptor signaling pathway" EXACT [GOC:bf] synonym: "phospholipase C-activating angiotensin receptor signaling pathway" EXACT [GOC:bf] synonym: "phospholipase C-activating angiotensin-mediated signaling pathway" RELATED [] synonym: "PLC-activating angiotensin receptor signaling pathway" EXACT [GOC:bf] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0038166 ! angiotensin-activated signaling pathway created_by: rfoulger creation_date: 2012-06-13T11:28:15Z [Term] id: GO:0086098 name: angiotensin-activated signaling pathway involved in heart process namespace: biological_process def: "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf] synonym: "angiotensin receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "angiotensin-mediated signaling pathway involved in heart process" RELATED [] is_a: GO:0038166 ! angiotensin-activated signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0038166 ! angiotensin-activated signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: rfoulger [Term] id: GO:0086099 name: phospholipase C-activating angiotensin-activated signaling pathway involved in heart process namespace: biological_process def: "An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" EXACT [GOC:bf] synonym: "cardiac angiotensin receptor signaling pathway via activation of PLC" EXACT [GOC:bf] synonym: "Gq-coupled angiotensin receptor signaling pathway involved in heart process" EXACT [PMID:17376402] synonym: "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process" RELATED [] synonym: "PLC-activating angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf] is_a: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway is_a: GO:0086098 ! angiotensin-activated signaling pathway involved in heart process intersection_of: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: rfoulger [Term] id: GO:0086100 name: endothelin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869] synonym: "endothelin signaling pathway" RELATED [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: rfoulger [Term] id: GO:0086101 name: endothelin receptor signaling pathway involved in heart process namespace: biological_process def: "An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "endothelin receptor signalling pathway involved in heart process" EXACT [GOC:bf] is_a: GO:0086100 ! endothelin receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0086100 ! endothelin receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process created_by: rfoulger [Term] id: GO:0086102 name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to an decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:bf] synonym: "adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity" EXACT [GOC:bf] synonym: "Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" BROAD [GOC:bf] synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current" EXACT [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel" EXACT [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007197 ! adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway is_a: GO:0086033 ! G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate intersection_of: GO:0007197 ! adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway intersection_of: part_of GO:0010459 ! negative regulation of heart rate created_by: rfoulger [Term] id: GO:0086103 name: G protein-coupled receptor signaling pathway involved in heart process namespace: biological_process def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf] synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process relationship: part_of GO:0003015 ! heart process created_by: rfoulger creation_date: 2012-03-19T01:28:23Z [Term] id: GO:0089700 name: protein kinase D signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dos, GOC:mah] synonym: "PKD signal transduction" EXACT [GOC:signaling] synonym: "PKD signaling cascade" RELATED [GOC:mah] synonym: "protein kinase D signal transduction" EXACT [GOC:signaling] synonym: "protein kinase D signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase D signalling cascade" RELATED [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0089701 name: U2AF namespace: cellular_component def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565] synonym: "U2 accessory factor" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0089702 name: undecaprenyl-phosphate glucose phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.31, GOC:dos, GOC:imk] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0089703 name: L-aspartate transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0034487 ! vacuolar amino acid transmembrane transport is_a: GO:0070778 ! L-aspartate transmembrane transport [Term] id: GO:0089704 name: L-glutamate transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0046618 ! drug export is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] id: GO:0089705 name: protein localization to outer membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane." [GOC:dos, PMID:12823819] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0089706 name: L-ornithine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0046618 ! drug export is_a: GO:1903352 ! L-ornithine transmembrane transport [Term] id: GO:0089707 name: L-lysine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0046618 ! drug export is_a: GO:1903401 ! L-lysine transmembrane transport [Term] id: GO:0089708 name: L-histidine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0046618 ! drug export is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:1902024 ! L-histidine transport is_a: GO:1990822 ! basic amino acid transmembrane transport [Term] id: GO:0089709 name: L-histidine transmembrane transport namespace: biological_process def: "The directed movement of L-histidine across a membrane." [PMID:21307582] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] id: GO:0089710 name: endocytic targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits." [PMID:8918456] is_a: GO:0005515 ! protein binding [Term] id: GO:0089713 name: Cbf1-Met4-Met28 complex namespace: cellular_component def: "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation." [PMID:8665859, PMID:9171357] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0089714 name: UDP-N-acetyl-D-mannosamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336] xref: EC:1.1.1.336 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0089715 name: tRNA m6t6A37 methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine." [PMID:25063302] comment: This activity is distinct from 'tRNA (adenine-N6-)-methyltransferase activity' (GO:0016430) in that it requires the presence of a threonylcarbamoyl modification. xref: MetaCyc:RXN0-7114 is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0089716 name: Pip2-Oaf1 complex namespace: cellular_component def: "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins." [PMID:8972187, PMID:9288897] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0089717 name: spanning component of membrane namespace: cellular_component def: "The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:dos] is_a: GO:0016021 ! integral component of membrane [Term] id: GO:0089718 name: amino acid import across plasma membrane namespace: biological_process alt_id: GO:0043092 alt_id: GO:0044745 alt_id: GO:1902837 def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "amino acid import into cell" EXACT [] synonym: "amino acid transmembrane import" BROAD [] synonym: "L-amino acid import" BROAD [] synonym: "L-amino acid uptake" NARROW [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0043090 ! amino acid import is_a: GO:0098739 ! import across plasma membrane created_by: janelomax creation_date: 2012-11-14T14:21:41Z [Term] id: GO:0089719 name: RHG protein domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)." [GOC:dos, GOC:ha] synonym: "iap binding domain binding" EXACT [] synonym: "inhibitor of apoptosis binding domain binding" EXACT [] synonym: "reaper hid grim domain binding" EXACT [] synonym: "RHG domain binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0089720 name: caspase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a caspase family protein." [GOC:dos, GOC:ha] is_a: GO:0002020 ! protease binding [Term] id: GO:0089721 name: phosphoenolpyruvate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other." [GOC:dos] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity relationship: part_of GO:0089722 ! phosphoenolpyruvate transmembrane transport [Term] id: GO:0089722 name: phosphoenolpyruvate transmembrane transport namespace: biological_process def: "The directed movement of phosphoenolpytuvate across a membrane." [GOC:dos] is_a: GO:0015714 ! phosphoenolpyruvate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0090001 name: replication fork arrest at tRNA locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest created_by: tanyaberardini creation_date: 2009-06-24T11:36:15Z [Term] id: GO:0090006 name: regulation of linear element assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb] synonym: "regulation of linear element assembly" RELATED [GOC:dph] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0060629 ! regulation of homologous chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030999 ! linear element assembly relationship: regulates GO:0030999 ! linear element assembly created_by: tanyaberardini creation_date: 2009-07-17T01:05:13Z [Term] id: GO:0090007 name: obsolete regulation of mitotic anaphase namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "regulation of mitotic anaphase" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2009-07-17T01:08:58Z [Term] id: GO:0090008 name: hypoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009888 ! tissue development created_by: tanyaberardini creation_date: 2009-07-29T10:25:54Z [Term] id: GO:0090009 name: primitive streak formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001702 ! gastrulation with mouth forming second relationship: part_of GO:0009948 ! anterior/posterior axis specification created_by: tanyaberardini creation_date: 2009-07-29T10:31:31Z [Term] id: GO:0090010 name: transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0090009 ! primitive streak formation relationship: part_of GO:0090009 ! primitive streak formation created_by: tanyaberardini creation_date: 2009-07-29T10:38:40Z [Term] id: GO:0090011 name: Wnt signaling pathway involved in primitive streak formation namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "Wnt receptor signaling pathway involved in primitive streak formation" EXACT [] synonym: "Wnt receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in primitive streak formation" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0090009 ! primitive streak formation relationship: part_of GO:0090009 ! primitive streak formation created_by: tanyaberardini creation_date: 2009-07-29T10:44:53Z [Term] id: GO:0090012 name: negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090013 ! regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation relationship: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation created_by: tanyaberardini creation_date: 2009-07-29T10:51:57Z [Term] id: GO:0090013 name: regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation relationship: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation created_by: tanyaberardini creation_date: 2009-07-29T10:54:44Z [Term] id: GO:0090014 name: leaflet formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0060794 ! leaflet morphogenesis created_by: tanyaberardini creation_date: 2009-07-29T11:05:37Z [Term] id: GO:0090015 name: positive regulation of leaflet formation by auxin mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of leaflet formation by auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009734 ! auxin-activated signaling pathway is_a: GO:0090016 ! regulation of leaflet formation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis is_a: GO:1905623 ! positive regulation of leaf development relationship: positively_regulates GO:0090014 ! leaflet formation created_by: tanyaberardini creation_date: 2009-07-29T11:18:45Z [Term] id: GO:0090016 name: regulation of leaflet formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:1901371 ! regulation of leaf morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090014 ! leaflet formation relationship: regulates GO:0090014 ! leaflet formation created_by: tanyaberardini creation_date: 2009-07-29T11:23:48Z [Term] id: GO:0090017 name: anterior neural plate formation namespace: biological_process def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021990 ! neural plate formation created_by: tanyaberardini creation_date: 2009-07-29T11:31:35Z [Term] id: GO:0090018 name: posterior neural plate formation namespace: biological_process def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021990 ! neural plate formation created_by: tanyaberardini creation_date: 2009-07-29T11:32:08Z [Term] id: GO:0090019 name: obsolete regulation of transcription involved in anterior neural plate formation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: tanyaberardini creation_date: 2009-07-29T11:38:28Z [Term] id: GO:0090020 name: obsolete regulation of transcription involved in posterior neural plate formation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: tanyaberardini creation_date: 2009-07-29T11:39:29Z [Term] id: GO:0090021 name: positive regulation of posterior neural plate formation by Wnt signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb] synonym: "positive regulation of posterior neural plate formation by Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of posterior neural plate formation by Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of posterior neural plate formation by Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: positively_regulates GO:0090018 ! posterior neural plate formation created_by: tanyaberardini creation_date: 2009-07-29T11:44:13Z [Term] id: GO:0090022 name: regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030593 ! neutrophil chemotaxis relationship: regulates GO:0030593 ! neutrophil chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:09:34Z [Term] id: GO:0090023 name: positive regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902624 ! positive regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030593 ! neutrophil chemotaxis relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:12:23Z [Term] id: GO:0090024 name: negative regulation of neutrophil chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis is_a: GO:0090022 ! regulation of neutrophil chemotaxis is_a: GO:1902623 ! negative regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030593 ! neutrophil chemotaxis relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:13:09Z [Term] id: GO:0090025 name: regulation of monocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002548 ! monocyte chemotaxis relationship: regulates GO:0002548 ! monocyte chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:17:03Z [Term] id: GO:0090026 name: positive regulation of monocyte chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002548 ! monocyte chemotaxis relationship: positively_regulates GO:0002548 ! monocyte chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:18:54Z [Term] id: GO:0090027 name: negative regulation of monocyte chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002548 ! monocyte chemotaxis relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis created_by: tanyaberardini creation_date: 2009-08-03T10:19:40Z [Term] id: GO:0090028 name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion created_by: tanyaberardini creation_date: 2009-08-03T10:25:27Z [Term] id: GO:0090029 name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion created_by: tanyaberardini creation_date: 2009-08-03T10:27:04Z [Term] id: GO:0090030 name: regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process created_by: tanyaberardini creation_date: 2009-08-03T10:38:27Z [Term] id: GO:0090031 name: positive regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process created_by: tanyaberardini creation_date: 2009-08-03T10:40:32Z [Term] id: GO:0090032 name: negative regulation of steroid hormone biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process created_by: tanyaberardini creation_date: 2009-08-03T10:41:35Z [Term] id: GO:0090033 name: positive regulation of filamentous growth namespace: biological_process def: "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] is_a: GO:0010570 ! regulation of filamentous growth is_a: GO:0045927 ! positive regulation of growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030447 ! filamentous growth relationship: positively_regulates GO:0030447 ! filamentous growth created_by: tanyaberardini creation_date: 2009-08-03T11:04:21Z [Term] id: GO:0090034 name: regulation of chaperone-mediated protein complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051131 ! chaperone-mediated protein complex assembly relationship: regulates GO:0051131 ! chaperone-mediated protein complex assembly created_by: tanyaberardini creation_date: 2009-08-03T11:12:37Z [Term] id: GO:0090035 name: positive regulation of chaperone-mediated protein complex assembly namespace: biological_process def: "Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0090034 ! regulation of chaperone-mediated protein complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly relationship: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly created_by: tanyaberardini creation_date: 2009-08-03T11:15:25Z [Term] id: GO:0090036 name: regulation of protein kinase C signaling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] synonym: "regulation of protein kinase C signalling cascade" RELATED [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070528 ! protein kinase C signaling relationship: regulates GO:0070528 ! protein kinase C signaling created_by: tanyaberardini creation_date: 2009-08-03T11:27:26Z [Term] id: GO:0090037 name: positive regulation of protein kinase C signaling namespace: biological_process def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "positive regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of protein kinase C signalling cascade" EXACT [GOC:mah] is_a: GO:0090036 ! regulation of protein kinase C signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070528 ! protein kinase C signaling relationship: positively_regulates GO:0070528 ! protein kinase C signaling created_by: tanyaberardini creation_date: 2009-08-03T11:28:44Z [Term] id: GO:0090038 name: negative regulation of protein kinase C signaling namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] synonym: "negative regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of protein kinase C signalling cascade" RELATED [GOC:mah] is_a: GO:0090036 ! regulation of protein kinase C signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070528 ! protein kinase C signaling relationship: negatively_regulates GO:0070528 ! protein kinase C signaling created_by: tanyaberardini creation_date: 2009-08-03T11:29:33Z [Term] id: GO:0090042 name: tubulin deacetylation namespace: biological_process def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0006476 ! protein deacetylation created_by: tanyaberardini creation_date: 2009-08-03T11:50:47Z [Term] id: GO:0090043 name: regulation of tubulin deacetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090311 ! regulation of protein deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090042 ! tubulin deacetylation relationship: regulates GO:0090042 ! tubulin deacetylation created_by: tanyaberardini creation_date: 2009-08-03T11:53:07Z [Term] id: GO:0090044 name: positive regulation of tubulin deacetylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090043 ! regulation of tubulin deacetylation is_a: GO:0090312 ! positive regulation of protein deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090042 ! tubulin deacetylation relationship: positively_regulates GO:0090042 ! tubulin deacetylation created_by: tanyaberardini creation_date: 2009-08-03T11:54:18Z [Term] id: GO:0090045 name: positive regulation of deacetylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0150065 ! regulation of deacetylase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019213 ! deacetylase activity relationship: positively_regulates GO:0019213 ! deacetylase activity created_by: tanyaberardini creation_date: 2009-08-03T12:00:14Z [Term] id: GO:0090046 name: obsolete regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. synonym: "regulation of transcription regulator activity" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2009-08-07T10:19:57Z [Term] id: GO:0090047 name: obsolete positive regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. synonym: "positive regulation of transcription regulator activity" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2009-08-07T10:24:24Z [Term] id: GO:0090048 name: obsolete negative regulation of transcription regulator activity namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. synonym: "negative regulation of transcription regulator activity" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2009-08-07T10:25:04Z [Term] id: GO:0090049 name: regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration is_a: GO:1903670 ! regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis created_by: tanyaberardini creation_date: 2009-08-07T10:37:16Z [Term] id: GO:0090050 name: positive regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis is_a: GO:1903672 ! positive regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis created_by: tanyaberardini creation_date: 2009-08-07T10:41:09Z [Term] id: GO:0090051 name: negative regulation of cell migration involved in sprouting angiogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis is_a: GO:1903671 ! negative regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis created_by: tanyaberardini creation_date: 2009-08-07T10:42:00Z [Term] id: GO:0090052 name: regulation of chromatin silencing at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030702 ! chromatin silencing at centromere relationship: regulates GO:0030702 ! chromatin silencing at centromere created_by: tanyaberardini creation_date: 2009-08-07T10:47:41Z [Term] id: GO:0090053 name: positive regulation of chromatin silencing at centromere namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090052 ! regulation of chromatin silencing at centromere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030702 ! chromatin silencing at centromere relationship: positively_regulates GO:0030702 ! chromatin silencing at centromere created_by: tanyaberardini creation_date: 2009-08-07T10:49:40Z [Term] id: GO:0090054 name: regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: tanyaberardini creation_date: 2009-08-07T10:52:59Z [Term] id: GO:0090055 name: positive regulation of chromatin silencing at silent mating-type cassette namespace: biological_process def: "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: tanyaberardini creation_date: 2009-08-07T10:54:36Z [Term] id: GO:0090056 name: regulation of chlorophyll metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb] is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015994 ! chlorophyll metabolic process relationship: regulates GO:0015994 ! chlorophyll metabolic process created_by: tanyaberardini creation_date: 2009-08-07T11:47:27Z [Term] id: GO:0090057 name: root radial pattern formation namespace: biological_process def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0009956 ! radial pattern formation relationship: part_of GO:0048364 ! root development created_by: tanyaberardini creation_date: 2009-08-11T02:58:06Z [Term] id: GO:0090058 name: metaxylem development namespace: biological_process def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0010089 ! xylem development created_by: tanyaberardini creation_date: 2009-08-11T03:05:15Z [Term] id: GO:0090059 name: protoxylem development namespace: biological_process def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0010089 ! xylem development created_by: tanyaberardini creation_date: 2009-08-11T03:08:06Z [Term] id: GO:0090060 name: regulation of metaxylem development namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090058 ! metaxylem development relationship: regulates GO:0090058 ! metaxylem development created_by: tanyaberardini creation_date: 2009-08-11T03:14:54Z [Term] id: GO:0090062 name: regulation of trehalose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005991 ! trehalose metabolic process relationship: regulates GO:0005991 ! trehalose metabolic process created_by: tanyaberardini creation_date: 2009-08-12T11:24:29Z [Term] id: GO:0090063 name: positive regulation of microtubule nucleation namespace: biological_process def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031116 ! positive regulation of microtubule polymerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007020 ! microtubule nucleation relationship: positively_regulates GO:0007020 ! microtubule nucleation created_by: tanyaberardini creation_date: 2009-08-12T11:33:09Z [Term] id: GO:0090064 name: activation of microtubule nucleation namespace: biological_process def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0090063 ! positive regulation of microtubule nucleation created_by: tanyaberardini creation_date: 2009-08-12T11:36:15Z [Term] id: GO:0090065 name: regulation of production of siRNA involved in RNA interference namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah] is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030422 ! production of siRNA involved in RNA interference relationship: regulates GO:0030422 ! production of siRNA involved in RNA interference created_by: tanyaberardini creation_date: 2009-08-12T11:41:09Z [Term] id: GO:0090066 name: regulation of anatomical structure size namespace: biological_process def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality created_by: tanyaberardini creation_date: 2009-09-02T11:00:08Z [Term] id: GO:0090067 name: regulation of thalamus size namespace: biological_process def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb] is_a: GO:0090066 ! regulation of anatomical structure size created_by: tanyaberardini creation_date: 2009-09-02T11:03:03Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022402 ! cell cycle process relationship: positively_regulates GO:0022402 ! cell cycle process created_by: tanyaberardini creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090069 name: regulation of ribosome biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042254 ! ribosome biogenesis relationship: regulates GO:0042254 ! ribosome biogenesis created_by: tanyaberardini creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090070 name: positive regulation of ribosome biogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042254 ! ribosome biogenesis relationship: positively_regulates GO:0042254 ! ribosome biogenesis created_by: tanyaberardini creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090071 name: negative regulation of ribosome biogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042254 ! ribosome biogenesis relationship: negatively_regulates GO:0042254 ! ribosome biogenesis created_by: tanyaberardini creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090072 name: obsolete positive regulation of sodium ion transport via voltage-gated sodium channel activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "positive regulation of sodium ion transport via voltage-gated sodium channel activity" EXACT [] is_obsolete: true consider: GO:0005248 created_by: tanyaberardini creation_date: 2009-09-11T10:46:13Z [Term] id: GO:0090073 name: positive regulation of protein homodimerization activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0043496 ! regulation of protein homodimerization activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042803 ! protein homodimerization activity relationship: positively_regulates GO:0042803 ! protein homodimerization activity created_by: tanyaberardini creation_date: 2009-09-11T11:15:40Z [Term] id: GO:0090074 name: negative regulation of protein homodimerization activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0043496 ! regulation of protein homodimerization activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042803 ! protein homodimerization activity relationship: negatively_regulates GO:0042803 ! protein homodimerization activity created_by: tanyaberardini creation_date: 2009-09-11T11:15:40Z [Term] id: GO:0090075 name: relaxation of muscle namespace: biological_process def: "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain." [GOC:BHF, GOC:rl, PMID:19996365] is_a: GO:0003012 ! muscle system process created_by: tanyaberardini creation_date: 2009-09-11T11:43:38Z [Term] id: GO:0090076 name: relaxation of skeletal muscle namespace: biological_process def: "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:BHF, GOC:rl] is_a: GO:0090075 ! relaxation of muscle created_by: tanyaberardini creation_date: 2009-09-11T11:44:32Z [Term] id: GO:0090077 name: foam cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation created_by: tanyaberardini creation_date: 2009-09-15T03:46:30Z [Term] id: GO:0090078 name: smooth muscle derived foam cell differentiation namespace: biological_process def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation created_by: tanyaberardini creation_date: 2009-09-15T03:48:10Z [Term] id: GO:0090079 name: translation regulator activity, nucleic acid binding namespace: molecular_function def: "Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0003676 ! nucleic acid binding is_a: GO:0045182 ! translation regulator activity created_by: tanyaberardini creation_date: 2009-10-19T10:19:05Z [Term] id: GO:0090080 name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb] synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0043410 ! positive regulation of MAPK cascade intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: positively_regulates GO:0000165 ! MAPK cascade created_by: tanyaberardini creation_date: 2009-10-19T11:30:22Z [Term] id: GO:0090081 name: regulation of heart induction by regulation of canonical Wnt signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart] synonym: "regulation of heart induction by regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of heart induction by regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway is_a: GO:0090381 ! regulation of heart induction intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway relationship: regulates GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway created_by: tanyaberardini creation_date: 2009-10-23T10:55:18Z [Term] id: GO:0090082 name: positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart, PMID:16860783] synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development is_a: GO:0090081 ! regulation of heart induction by regulation of canonical Wnt signaling pathway is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1901321 ! positive regulation of heart induction created_by: tanyaberardini creation_date: 2009-10-23T10:58:03Z [Term] id: GO:0090083 name: regulation of inclusion body assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070841 ! inclusion body assembly relationship: regulates GO:0070841 ! inclusion body assembly created_by: tanyaberardini creation_date: 2009-10-23T11:07:22Z [Term] id: GO:0090084 name: negative regulation of inclusion body assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0090083 ! regulation of inclusion body assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070841 ! inclusion body assembly relationship: negatively_regulates GO:0070841 ! inclusion body assembly created_by: tanyaberardini creation_date: 2009-10-23T11:08:56Z [Term] id: GO:0090085 name: regulation of protein deubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016579 ! protein deubiquitination relationship: regulates GO:0016579 ! protein deubiquitination created_by: tanyaberardini creation_date: 2009-10-23T11:16:32Z [Term] id: GO:0090086 name: negative regulation of protein deubiquitination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0090085 ! regulation of protein deubiquitination is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016579 ! protein deubiquitination relationship: negatively_regulates GO:0016579 ! protein deubiquitination created_by: tanyaberardini creation_date: 2009-10-23T11:18:06Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015833 ! peptide transport relationship: regulates GO:0015833 ! peptide transport created_by: tanyaberardini creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090088 name: regulation of oligopeptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb] is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006857 ! oligopeptide transport relationship: regulates GO:0006857 ! oligopeptide transport created_by: tanyaberardini creation_date: 2009-10-23T11:23:18Z [Term] id: GO:0090089 name: regulation of dipeptide transport namespace: biological_process def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0090088 ! regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042938 ! dipeptide transport relationship: regulates GO:0042938 ! dipeptide transport created_by: tanyaberardini creation_date: 2009-10-23T11:24:36Z [Term] id: GO:0090090 name: negative regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035414 def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] synonym: "negative regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "negative regulation of catenin import into nucleus" NARROW [] synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway relationship: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway created_by: tanyaberardini creation_date: 2009-10-30T11:27:17Z [Term] id: GO:0090091 name: positive regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022617 ! extracellular matrix disassembly relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly created_by: tanyaberardini creation_date: 2009-11-04T10:03:25Z [Term] id: GO:0090092 name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tanyaberardini creation_date: 2009-11-04T11:46:40Z [Term] id: GO:0090093 name: regulation of fungal-type cell wall beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process created_by: tanyaberardini creation_date: 2009-11-13T10:10:38Z [Term] id: GO:0090094 name: metanephric cap mesenchymal cell proliferation involved in metanephros development namespace: biological_process def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf, PMID:19161241] is_a: GO:0010463 ! mesenchymal cell proliferation is_a: GO:0072203 ! cell proliferation involved in metanephros development relationship: part_of GO:0072186 ! metanephric cap morphogenesis created_by: tanyaberardini creation_date: 2009-11-13T10:34:10Z [Term] id: GO:0090095 name: regulation of metanephric cap mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development created_by: tanyaberardini creation_date: 2009-11-13T10:40:32Z [Term] id: GO:0090096 name: positive regulation of metanephric cap mesenchymal cell proliferation namespace: biological_process def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development created_by: tanyaberardini creation_date: 2009-11-13T10:40:32Z [Term] id: GO:0090100 name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tanyaberardini creation_date: 2009-11-13T10:55:53Z [Term] id: GO:0090101 name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway created_by: tanyaberardini creation_date: 2009-11-13T10:56:52Z [Term] id: GO:0090102 name: cochlea development namespace: biological_process def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048839 ! inner ear development created_by: tanyaberardini creation_date: 2009-11-18T11:42:15Z [Term] id: GO:0090103 name: cochlea morphogenesis namespace: biological_process def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0090102 ! cochlea development created_by: tanyaberardini creation_date: 2009-11-18T11:45:11Z [Term] id: GO:0090104 name: pancreatic epsilon cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb] synonym: "pancreatic E cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: tanyaberardini creation_date: 2009-11-18T11:48:52Z [Term] id: GO:0090105 name: pancreatic E cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation created_by: tanyaberardini creation_date: 2009-11-18T11:51:00Z [Term] id: GO:0090106 name: pancreatic E cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation created_by: tanyaberardini creation_date: 2009-11-18T11:51:41Z [Term] id: GO:0090107 name: regulation of high-density lipoprotein particle assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034380 ! high-density lipoprotein particle assembly relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly created_by: tanyaberardini creation_date: 2009-11-25T10:50:18Z [Term] id: GO:0090108 name: positive regulation of high-density lipoprotein particle assembly namespace: biological_process def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly created_by: tanyaberardini creation_date: 2009-11-25T10:50:18Z [Term] id: GO:0090109 name: regulation of cell-substrate junction assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] is_a: GO:0150116 ! regulation of cell-substrate junction organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007044 ! cell-substrate junction assembly relationship: regulates GO:0007044 ! cell-substrate junction assembly created_by: tanyaberardini creation_date: 2009-11-25T11:00:58Z [Term] id: GO:0090110 name: COPII-coated vesicle cargo loading namespace: biological_process def: "The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb] synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cargo loading into COPII-coated vesicle" EXACT [] synonym: "cargo selection into COPII-coated vesicle" EXACT [GOC:vw] synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0035459 ! vesicle cargo loading is_a: GO:0046907 ! intracellular transport is_a: GO:0051668 ! localization within membrane relationship: part_of GO:0090114 ! COPII-coated vesicle budding created_by: tanyaberardini creation_date: 2009-12-06T08:28:34Z [Term] id: GO:0090111 name: regulation of COPII vesicle uncoating namespace: biological_process def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090112 ! COPII vesicle uncoating relationship: regulates GO:0090112 ! COPII vesicle uncoating created_by: tanyaberardini creation_date: 2009-12-06T08:34:01Z [Term] id: GO:0090112 name: COPII vesicle uncoating namespace: biological_process def: "The process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0072319 ! vesicle uncoating relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: tanyaberardini creation_date: 2009-12-06T08:56:50Z [Term] id: GO:0090113 name: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis namespace: biological_process def: "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport created_by: tanyaberardini creation_date: 2009-12-06T09:16:14Z [Term] id: GO:0090114 name: COPII-coated vesicle budding namespace: biological_process def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0048194 ! Golgi vesicle budding relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: tanyaberardini creation_date: 2009-12-06T09:21:16Z [Term] id: GO:0090115 name: C-5 methylation on cytosine involved in chromatin silencing namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090116 ! C-5 methylation of cytosine relationship: part_of GO:0006346 ! methylation-dependent chromatin silencing created_by: tanyaberardini creation_date: 2009-12-07T11:55:16Z [Term] id: GO:0090116 name: C-5 methylation of cytosine namespace: biological_process def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine created_by: tanyaberardini creation_date: 2009-12-07T11:58:47Z [Term] id: GO:0090117 name: endosome to lysosome transport of low-density lipoprotein particle namespace: biological_process def: "The directed movement of low-density lipoprotein particle from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008333 ! endosome to lysosome transport is_a: GO:0090119 ! vesicle-mediated cholesterol transport created_by: tanyaberardini creation_date: 2009-12-07T12:04:34Z [Term] id: GO:0090118 name: receptor-mediated endocytosis involved in cholesterol transport namespace: biological_process def: "A receptor-mediated endocytosis process involved in intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb] synonym: "receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [] synonym: "receptor-mediated endocytosis of LDL" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:dph] synonym: "receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006898 ! receptor-mediated endocytosis intersection_of: part_of GO:0032367 ! intracellular cholesterol transport relationship: part_of GO:0032367 ! intracellular cholesterol transport created_by: tanyaberardini creation_date: 2009-12-07T12:06:05Z [Term] id: GO:0090119 name: vesicle-mediated cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport is_a: GO:0032367 ! intracellular cholesterol transport created_by: tanyaberardini creation_date: 2009-12-07T12:14:37Z [Term] id: GO:0090120 name: lysosome to ER cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum." [GOC:mah] synonym: "lysosome to endoplasmic reticulum cholesterol transport" EXACT [GOC:mah] is_a: GO:0007041 ! lysosomal transport is_a: GO:0090119 ! vesicle-mediated cholesterol transport relationship: occurs_in GO:0005737 ! cytoplasm created_by: tanyaberardini creation_date: 2009-12-07T12:22:12Z [Term] id: GO:0090121 name: low-density lipoprotein particle disassembly involved in cholesterol transport namespace: biological_process def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090495 ! low-density lipoprotein particle disassembly intersection_of: GO:0090495 ! low-density lipoprotein particle disassembly intersection_of: part_of GO:0030301 ! cholesterol transport relationship: part_of GO:0030301 ! cholesterol transport created_by: tanyaberardini creation_date: 2009-12-07T12:59:14Z [Term] id: GO:0090122 name: cholesterol ester hydrolysis involved in cholesterol transport namespace: biological_process def: "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008203 ! cholesterol metabolic process relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport created_by: tanyaberardini creation_date: 2009-12-07T01:06:54Z [Term] id: GO:0090123 name: lysosomal glycocalyx namespace: cellular_component def: "The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005764 ! lysosome created_by: tanyaberardini creation_date: 2009-12-07T01:16:20Z [Term] id: GO:0090124 name: N-4 methylation of cytosine namespace: biological_process def: "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine created_by: tanyaberardini creation_date: 2009-12-07T02:40:38Z [Term] id: GO:0090125 name: cell-cell adhesion involved in synapse maturation namespace: biological_process def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: part_of GO:0060074 ! synapse maturation relationship: part_of GO:0060074 ! synapse maturation created_by: tanyaberardini creation_date: 2009-12-07T02:43:24Z [Term] id: GO:0090126 name: protein-containing complex assembly involved in synapse maturation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "protein complex assembly involved in synapse maturation" RELATED [] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0065003 ! protein-containing complex assembly intersection_of: part_of GO:0060074 ! synapse maturation relationship: part_of GO:0060074 ! synapse maturation created_by: tanyaberardini creation_date: 2009-12-07T02:49:28Z [Term] id: GO:0090127 name: positive regulation of synapse maturation by synaptic transmission namespace: biological_process def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007268 ! chemical synaptic transmission is_a: GO:0090129 ! positive regulation of synapse maturation intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: positively_regulates GO:0060074 ! synapse maturation created_by: tanyaberardini creation_date: 2009-12-07T02:57:21Z [Term] id: GO:0090128 name: regulation of synapse maturation namespace: biological_process def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] subset: goslim_synapse is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060074 ! synapse maturation relationship: regulates GO:0060074 ! synapse maturation created_by: tanyaberardini creation_date: 2009-12-07T03:00:58Z [Term] id: GO:0090129 name: positive regulation of synapse maturation namespace: biological_process def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0090128 ! regulation of synapse maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060074 ! synapse maturation relationship: positively_regulates GO:0060074 ! synapse maturation created_by: tanyaberardini creation_date: 2009-12-07T03:00:58Z [Term] id: GO:0090130 name: tissue migration namespace: biological_process def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process created_by: tanyaberardini creation_date: 2009-12-07T03:13:55Z [Term] id: GO:0090131 name: mesenchyme migration namespace: biological_process def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration relationship: part_of GO:0072132 ! mesenchyme morphogenesis created_by: tanyaberardini creation_date: 2009-12-07T03:15:17Z [Term] id: GO:0090132 name: epithelium migration namespace: biological_process def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration created_by: tanyaberardini creation_date: 2009-12-07T03:19:34Z [Term] id: GO:0090133 name: mesendoderm migration namespace: biological_process def: "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090132 ! epithelium migration relationship: part_of GO:0007369 ! gastrulation relationship: part_of GO:0048382 ! mesendoderm development created_by: tanyaberardini creation_date: 2009-12-07T03:22:08Z [Term] id: GO:0090134 name: cell migration involved in mesendoderm migration namespace: biological_process def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042074 ! cell migration involved in gastrulation intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0090133 ! mesendoderm migration relationship: part_of GO:0090133 ! mesendoderm migration created_by: tanyaberardini creation_date: 2009-12-07T03:28:11Z [Term] id: GO:0090135 name: actin filament branching namespace: biological_process def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007015 ! actin filament organization created_by: tanyaberardini creation_date: 2009-12-08T01:53:14Z [Term] id: GO:0090136 name: epithelial cell-cell adhesion namespace: biological_process def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098609 ! cell-cell adhesion created_by: tanyaberardini creation_date: 2009-12-08T01:56:53Z [Term] id: GO:0090137 name: epithelial cell-cell adhesion involved in epithelium migration namespace: biological_process def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090136 ! epithelial cell-cell adhesion intersection_of: GO:0090136 ! epithelial cell-cell adhesion intersection_of: part_of GO:0090132 ! epithelium migration relationship: part_of GO:0090132 ! epithelium migration created_by: tanyaberardini creation_date: 2009-12-08T01:58:19Z [Term] id: GO:0090138 name: regulation of actin cytoskeleton organization by cell-cell adhesion namespace: biological_process def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: regulates GO:0030036 ! actin cytoskeleton organization created_by: tanyaberardini creation_date: 2009-12-08T02:05:00Z [Term] id: GO:0090139 name: mitochondrial DNA packaging namespace: biological_process def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: tanyaberardini creation_date: 2009-12-08T02:12:19Z [Term] id: GO:0090140 name: regulation of mitochondrial fission namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000266 ! mitochondrial fission relationship: regulates GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090141 name: positive regulation of mitochondrial fission namespace: biological_process def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000266 ! mitochondrial fission relationship: positively_regulates GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090143 name: nucleoid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "nucleoid organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization created_by: tanyaberardini creation_date: 2009-12-08T02:35:48Z [Term] id: GO:0090144 name: mitochondrial nucleoid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mitochondrial nucleoid organisation" EXACT [GOC:mah] is_a: GO:0090143 ! nucleoid organization intersection_of: GO:0090143 ! nucleoid organization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: tanyaberardini creation_date: 2009-12-08T02:38:26Z [Term] id: GO:0090145 name: mitochondrial nucleoid organization involved in mitochondrial fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mitochondrial nucleoid organisation involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] is_a: GO:0090144 ! mitochondrial nucleoid organization intersection_of: GO:0090144 ! mitochondrial nucleoid organization intersection_of: part_of GO:0000266 ! mitochondrial fission relationship: part_of GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T02:39:34Z [Term] id: GO:0090146 name: establishment of mitochondrion localization involved in mitochondrial fission namespace: biological_process def: "The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] synonym: "mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] is_a: GO:0051654 ! establishment of mitochondrion localization intersection_of: GO:0051654 ! establishment of mitochondrion localization intersection_of: part_of GO:0000266 ! mitochondrial fission relationship: part_of GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T02:53:15Z [Term] id: GO:0090147 name: regulation of establishment of mitochondrion localization involved in mitochondrial fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] synonym: "regulation of mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090146 ! establishment of mitochondrion localization involved in mitochondrial fission relationship: regulates GO:0090146 ! establishment of mitochondrion localization involved in mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T03:01:01Z [Term] id: GO:0090148 name: membrane fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "membrane scission" EXACT [] is_a: GO:0061024 ! membrane organization created_by: tanyaberardini creation_date: 2009-12-08T03:06:36Z [Term] id: GO:0090149 name: mitochondrial membrane fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "membrane fission involved in mitochondrial fission" EXACT [] synonym: "mitochondrial membrane scission" EXACT [] is_a: GO:0090148 ! membrane fission intersection_of: GO:0090148 ! membrane fission intersection_of: part_of GO:0000266 ! mitochondrial fission relationship: part_of GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T03:08:57Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0072657 ! protein localization to membrane created_by: tanyaberardini creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090151 name: establishment of protein localization to mitochondrial membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:0090150 ! establishment of protein localization to membrane created_by: tanyaberardini creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090152 name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT [] is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: part_of GO:0000266 ! mitochondrial fission relationship: part_of GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090153 name: regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1905038 ! regulation of membrane lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030148 ! sphingolipid biosynthetic process relationship: regulates GO:0030148 ! sphingolipid biosynthetic process created_by: tanyaberardini creation_date: 2009-12-08T03:25:49Z [Term] id: GO:0090154 name: positive regulation of sphingolipid biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030148 ! sphingolipid biosynthetic process relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process created_by: tanyaberardini creation_date: 2009-12-08T03:27:33Z [Term] id: GO:0090155 name: negative regulation of sphingolipid biosynthetic process namespace: biological_process alt_id: GO:0090157 def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis" RELATED [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process created_by: tanyaberardini creation_date: 2009-12-08T03:33:39Z [Term] id: GO:0090156 name: cellular sphingolipid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0055088 ! lipid homeostasis created_by: tanyaberardini creation_date: 2009-12-08T08:21:36Z [Term] id: GO:0090158 name: endoplasmic reticulum membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "endoplasmic reticulum membrane organisation" EXACT [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0007029 ! endoplasmic reticulum organization created_by: tanyaberardini creation_date: 2009-12-08T08:27:17Z [Term] id: GO:0090159 name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation" EXACT [GOC:mah] is_a: GO:0030148 ! sphingolipid biosynthetic process intersection_of: GO:0030148 ! sphingolipid biosynthetic process intersection_of: part_of GO:0090158 ! endoplasmic reticulum membrane organization relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization created_by: tanyaberardini creation_date: 2009-12-08T08:31:13Z [Term] id: GO:0090160 name: Golgi to lysosome transport namespace: biological_process def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006896 ! Golgi to vacuole transport is_a: GO:0007041 ! lysosomal transport is_a: GO:0016482 ! cytosolic transport created_by: tanyaberardini creation_date: 2009-12-08T08:35:13Z [Term] id: GO:0090161 name: Golgi ribbon formation namespace: biological_process def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization created_by: tanyaberardini creation_date: 2009-12-08T08:38:14Z [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity created_by: tanyaberardini creation_date: 2009-12-08T08:58:27Z [Term] id: GO:0090163 name: establishment of epithelial cell planar polarity namespace: biological_process def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090162 ! establishment of epithelial cell polarity created_by: tanyaberardini creation_date: 2009-12-08T08:59:57Z [Term] id: GO:0090164 name: asymmetric Golgi ribbon formation namespace: biological_process def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090161 ! Golgi ribbon formation relationship: part_of GO:0090162 ! establishment of epithelial cell polarity created_by: tanyaberardini creation_date: 2009-12-08T09:02:45Z [Term] id: GO:0090165 name: regulation of secretion by asymmetric Golgi ribbon formation namespace: biological_process def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090164 ! asymmetric Golgi ribbon formation intersection_of: GO:0090164 ! asymmetric Golgi ribbon formation intersection_of: regulates GO:0046903 ! secretion created_by: tanyaberardini creation_date: 2009-12-08T09:05:16Z [Term] id: GO:0090166 name: Golgi disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:1903008 ! organelle disassembly relationship: part_of GO:0048313 ! Golgi inheritance created_by: tanyaberardini creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090167 name: Golgi distribution to daughter cells namespace: biological_process def: "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:0051645 ! Golgi localization relationship: part_of GO:0048313 ! Golgi inheritance created_by: tanyaberardini creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090168 name: Golgi reassembly namespace: biological_process def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007030 ! Golgi organization is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0048313 ! Golgi inheritance created_by: tanyaberardini creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090169 name: regulation of spindle assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090224 ! regulation of spindle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051225 ! spindle assembly relationship: regulates GO:0051225 ! spindle assembly created_by: tanyaberardini creation_date: 2009-12-11T10:17:51Z [Term] id: GO:0090170 name: regulation of Golgi inheritance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048313 ! Golgi inheritance relationship: regulates GO:0048313 ! Golgi inheritance created_by: tanyaberardini creation_date: 2009-12-11T10:21:59Z [Term] id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002063 ! chondrocyte development created_by: tanyaberardini creation_date: 2009-12-11T10:36:02Z [Term] id: GO:0090172 name: microtubule cytoskeleton organization involved in homologous chromosome segregation namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "microtubule cytoskeleton organisation involved in homologous chromosome segregation" EXACT [GOC:mah] synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0045143 ! homologous chromosome segregation relationship: part_of GO:0045143 ! homologous chromosome segregation created_by: tanyaberardini creation_date: 2009-12-11T11:07:42Z [Term] id: GO:0090173 name: regulation of synaptonemal complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0060629 ! regulation of homologous chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007130 ! synaptonemal complex assembly relationship: regulates GO:0007130 ! synaptonemal complex assembly created_by: tanyaberardini creation_date: 2009-12-11T11:40:36Z [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048284 ! organelle fusion is_a: GO:0061025 ! membrane fusion created_by: tanyaberardini creation_date: 2009-12-11T11:44:58Z [Term] id: GO:0090175 name: regulation of establishment of planar polarity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001736 ! establishment of planar polarity relationship: regulates GO:0001736 ! establishment of planar polarity created_by: tanyaberardini creation_date: 2009-12-14T10:29:41Z [Term] id: GO:0090176 name: microtubule cytoskeleton organization involved in establishment of planar polarity namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "microtubule cytoskeleton organisation involved in establishment of planar polarity" EXACT [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0001736 ! establishment of planar polarity relationship: part_of GO:0001736 ! establishment of planar polarity created_by: tanyaberardini creation_date: 2009-12-14T10:34:25Z [Term] id: GO:0090177 name: establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0001736 ! establishment of planar polarity intersection_of: part_of GO:0001843 ! neural tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: tanyaberardini creation_date: 2009-12-14T10:38:46Z [Term] id: GO:0090178 name: regulation of establishment of planar polarity involved in neural tube closure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0090175 ! regulation of establishment of planar polarity is_a: GO:1905276 ! regulation of epithelial tube formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure created_by: tanyaberardini creation_date: 2009-12-14T11:14:27Z [Term] id: GO:0090179 name: planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0001843 ! neural tube closure relationship: part_of GO:0001843 ! neural tube closure created_by: tanyaberardini creation_date: 2009-12-14T11:20:27Z [Term] id: GO:0090180 name: positive regulation of thiamine biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:dph, GOC:tb] synonym: "positive regulation of thiamin biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0070623 ! regulation of thiamine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009228 ! thiamine biosynthetic process relationship: positively_regulates GO:0009228 ! thiamine biosynthetic process created_by: tanyaberardini creation_date: 2009-12-18T10:30:07Z [Term] id: GO:0090181 name: regulation of cholesterol metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008203 ! cholesterol metabolic process relationship: regulates GO:0008203 ! cholesterol metabolic process created_by: tanyaberardini creation_date: 2009-12-18T10:33:49Z [Term] id: GO:0090182 name: regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033299 ! secretion of lysosomal enzymes relationship: regulates GO:0033299 ! secretion of lysosomal enzymes created_by: tanyaberardini creation_date: 2009-12-18T10:40:46Z [Term] id: GO:0090183 name: regulation of kidney development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001822 ! kidney development relationship: regulates GO:0001822 ! kidney development created_by: tanyaberardini creation_date: 2009-12-18T10:50:56Z [Term] id: GO:0090184 name: positive regulation of kidney development namespace: biological_process def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001822 ! kidney development relationship: positively_regulates GO:0001822 ! kidney development created_by: tanyaberardini creation_date: 2009-12-18T10:52:01Z [Term] id: GO:0090185 name: negative regulation of kidney development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001822 ! kidney development relationship: negatively_regulates GO:0001822 ! kidney development created_by: tanyaberardini creation_date: 2009-12-18T10:58:45Z [Term] id: GO:0090186 name: regulation of pancreatic juice secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030157 ! pancreatic juice secretion relationship: regulates GO:0030157 ! pancreatic juice secretion created_by: tanyaberardini creation_date: 2009-12-18T11:03:24Z [Term] id: GO:0090187 name: positive regulation of pancreatic juice secretion namespace: biological_process def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0090186 ! regulation of pancreatic juice secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030157 ! pancreatic juice secretion relationship: positively_regulates GO:0030157 ! pancreatic juice secretion created_by: tanyaberardini creation_date: 2009-12-18T11:03:24Z [Term] id: GO:0090188 name: negative regulation of pancreatic juice secretion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:0090186 ! regulation of pancreatic juice secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030157 ! pancreatic juice secretion relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion created_by: tanyaberardini creation_date: 2009-12-18T11:03:24Z [Term] id: GO:0090189 name: regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: tanyaberardini creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090190 name: positive regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: tanyaberardini creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090191 name: negative regulation of branching involved in ureteric bud morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis created_by: tanyaberardini creation_date: 2009-12-18T11:11:17Z [Term] id: GO:0090192 name: regulation of glomerulus development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032835 ! glomerulus development relationship: regulates GO:0032835 ! glomerulus development created_by: tanyaberardini creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090193 name: positive regulation of glomerulus development namespace: biological_process def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032835 ! glomerulus development relationship: positively_regulates GO:0032835 ! glomerulus development created_by: tanyaberardini creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090194 name: negative regulation of glomerulus development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032835 ! glomerulus development relationship: negatively_regulates GO:0032835 ! glomerulus development created_by: tanyaberardini creation_date: 2009-12-18T11:17:13Z [Term] id: GO:0090195 name: chemokine secretion namespace: biological_process def: "The regulated release of chemokines from a cell." [GOC:BHF, GOC:rl] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032602 ! chemokine production created_by: tanyaberardini creation_date: 2009-12-18T11:26:20Z [Term] id: GO:0090196 name: regulation of chemokine secretion namespace: biological_process def: "Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl] is_a: GO:0032642 ! regulation of chemokine production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090195 ! chemokine secretion relationship: regulates GO:0090195 ! chemokine secretion created_by: tanyaberardini creation_date: 2009-12-18T11:28:00Z [Term] id: GO:0090197 name: positive regulation of chemokine secretion namespace: biological_process def: "Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0090196 ! regulation of chemokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090195 ! chemokine secretion relationship: positively_regulates GO:0090195 ! chemokine secretion created_by: tanyaberardini creation_date: 2009-12-18T11:28:00Z [Term] id: GO:0090198 name: negative regulation of chemokine secretion namespace: biological_process def: "Any process that decreases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell." [GOC:BHF, GOC:rl] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0090196 ! regulation of chemokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090195 ! chemokine secretion relationship: negatively_regulates GO:0090195 ! chemokine secretion created_by: tanyaberardini creation_date: 2009-12-18T11:28:00Z [Term] id: GO:0090199 name: regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly regulate this process. is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001836 ! release of cytochrome c from mitochondria relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria created_by: tanyaberardini creation_date: 2009-12-18T11:35:20Z [Term] id: GO:0090200 name: positive regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process. is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria created_by: tanyaberardini creation_date: 2009-12-18T11:35:20Z [Term] id: GO:0090201 name: negative regulation of release of cytochrome c from mitochondria namespace: biological_process def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process. is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria created_by: tanyaberardini creation_date: 2009-12-18T11:35:20Z [Term] id: GO:0090202 name: gene looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150] is_a: GO:0006325 ! chromatin organization is_a: GO:0090579 ! dsDNA loop formation created_by: tanyaberardini creation_date: 2009-12-18T11:56:00Z [Term] id: GO:0090203 name: transcriptional activation by promoter-terminator looping namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb] synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0090202 ! gene looping created_by: tanyaberardini creation_date: 2009-12-18T11:58:32Z [Term] id: GO:0090204 name: protein localization to nuclear pore namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb] synonym: "protein localisation to nuclear pore" EXACT [GOC:mah] is_a: GO:0090435 ! protein localization to nuclear envelope created_by: tanyaberardini creation_date: 2009-12-18T12:05:01Z [Term] id: GO:0090205 name: positive regulation of cholesterol metabolic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0090181 ! regulation of cholesterol metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008203 ! cholesterol metabolic process relationship: positively_regulates GO:0008203 ! cholesterol metabolic process created_by: tanyaberardini creation_date: 2009-12-23T10:27:37Z [Term] id: GO:0090206 name: negative regulation of cholesterol metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0090181 ! regulation of cholesterol metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008203 ! cholesterol metabolic process relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process created_by: tanyaberardini creation_date: 2009-12-23T10:27:37Z [Term] id: GO:0090207 name: regulation of triglyceride metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006641 ! triglyceride metabolic process relationship: regulates GO:0006641 ! triglyceride metabolic process created_by: tanyaberardini creation_date: 2009-12-23T10:35:06Z [Term] id: GO:0090208 name: positive regulation of triglyceride metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006641 ! triglyceride metabolic process relationship: positively_regulates GO:0006641 ! triglyceride metabolic process created_by: tanyaberardini creation_date: 2009-12-23T10:35:06Z [Term] id: GO:0090209 name: negative regulation of triglyceride metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006641 ! triglyceride metabolic process relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process created_by: tanyaberardini creation_date: 2009-12-23T10:35:06Z [Term] id: GO:0090210 name: regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] synonym: "regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060856 ! establishment of blood-brain barrier relationship: regulates GO:0060856 ! establishment of blood-brain barrier created_by: tanyaberardini creation_date: 2009-12-23T12:15:53Z [Term] id: GO:0090211 name: positive regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0090210 ! regulation of establishment of blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060856 ! establishment of blood-brain barrier relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier created_by: tanyaberardini creation_date: 2009-12-23T12:15:53Z [Term] id: GO:0090212 name: negative regulation of establishment of blood-brain barrier namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] synonym: "negative regulation of establishment of BBB" EXACT [PMID:20080302] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0090210 ! regulation of establishment of blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060856 ! establishment of blood-brain barrier relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier created_by: tanyaberardini creation_date: 2009-12-23T12:15:53Z [Term] id: GO:0090213 name: regulation of radial pattern formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb] synonym: "regulation of radial pattern specification" NARROW [GOC:tb] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009956 ! radial pattern formation relationship: regulates GO:0009956 ! radial pattern formation created_by: tanyaberardini creation_date: 2010-01-05T10:59:10Z [Term] id: GO:0090214 name: spongiotrophoblast layer developmental growth namespace: biological_process def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060712 ! spongiotrophoblast layer development created_by: tanyaberardini creation_date: 2010-01-08T12:10:44Z [Term] id: GO:0090215 name: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity relationship: regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity created_by: tanyaberardini creation_date: 2010-01-12T10:00:45Z [Term] id: GO:0090216 name: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity is_a: GO:0090218 ! positive regulation of lipid kinase activity is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity relationship: positively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity created_by: tanyaberardini creation_date: 2010-01-12T10:00:45Z [Term] id: GO:0090217 name: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity is_a: GO:0090219 ! negative regulation of lipid kinase activity is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity relationship: negatively_regulates GO:0016308 ! 1-phosphatidylinositol-4-phosphate 5-kinase activity created_by: tanyaberardini creation_date: 2010-01-12T10:00:45Z [Term] id: GO:0090218 name: positive regulation of lipid kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001727 ! lipid kinase activity relationship: positively_regulates GO:0001727 ! lipid kinase activity created_by: tanyaberardini creation_date: 2010-01-12T10:18:30Z [Term] id: GO:0090219 name: negative regulation of lipid kinase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0043550 ! regulation of lipid kinase activity is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001727 ! lipid kinase activity relationship: negatively_regulates GO:0001727 ! lipid kinase activity created_by: tanyaberardini creation_date: 2010-01-12T10:18:30Z [Term] id: GO:0090220 name: chromosome localization to nuclear envelope involved in homologous chromosome segregation namespace: biological_process def: "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287] synonym: "chromosome localisation to nuclear envelope involved in homologous chromosome segregation" EXACT [GOC:mah] is_a: GO:0022414 ! reproductive process is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0045143 ! homologous chromosome segregation created_by: tanyaberardini creation_date: 2010-01-13T10:20:33Z [Term] id: GO:0090221 name: mitotic spindle-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007020 ! microtubule nucleation created_by: tanyaberardini creation_date: 2010-01-13T10:42:37Z [Term] id: GO:0090222 name: centrosome-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center created_by: tanyaberardini creation_date: 2010-01-13T10:52:36Z [Term] id: GO:0090223 name: chromatin-templated microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007020 ! microtubule nucleation created_by: tanyaberardini creation_date: 2010-01-13T10:53:35Z [Term] id: GO:0090224 name: regulation of spindle organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of spindle organisation" EXACT [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007051 ! spindle organization relationship: regulates GO:0007051 ! spindle organization created_by: tanyaberardini creation_date: 2010-01-13T11:04:53Z [Term] id: GO:0090225 name: regulation of spindle density namespace: biological_process def: "Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality is_a: GO:0090224 ! regulation of spindle organization created_by: tanyaberardini creation_date: 2010-01-13T11:24:53Z [Term] id: GO:0090226 name: regulation of microtubule nucleation by Ran protein signal transduction namespace: biological_process def: "Any series of molecular signals in which a Ran GTPase relays one or more of the signals resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031291 ! Ran protein signal transduction intersection_of: GO:0031291 ! Ran protein signal transduction intersection_of: regulates GO:0007020 ! microtubule nucleation created_by: tanyaberardini creation_date: 2010-01-13T11:35:31Z [Term] id: GO:0090227 name: regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:2000030 ! regulation of response to red or far red light intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010017 ! red or far-red light signaling pathway relationship: regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090228 name: positive regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010017 ! red or far-red light signaling pathway relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090229 name: negative regulation of red or far-red light signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb] synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0090227 ! regulation of red or far-red light signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010017 ! red or far-red light signaling pathway relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway created_by: tanyaberardini creation_date: 2010-01-19T04:03:29Z [Term] id: GO:0090230 name: regulation of centromere complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034508 ! centromere complex assembly relationship: regulates GO:0034508 ! centromere complex assembly created_by: tanyaberardini creation_date: 2010-01-20T10:20:49Z [Term] id: GO:0090231 name: regulation of spindle checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate is_a: GO:1901976 ! regulation of cell cycle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031577 ! spindle checkpoint relationship: regulates GO:0031577 ! spindle checkpoint created_by: tanyaberardini creation_date: 2010-01-20T10:29:43Z [Term] id: GO:0090232 name: positive regulation of spindle checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] subset: gocheck_do_not_manually_annotate synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090231 ! regulation of spindle checkpoint is_a: GO:1901978 ! positive regulation of cell cycle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031577 ! spindle checkpoint relationship: positively_regulates GO:0031577 ! spindle checkpoint created_by: tanyaberardini creation_date: 2010-01-20T10:29:43Z [Term] id: GO:0090233 name: negative regulation of spindle checkpoint namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090231 ! regulation of spindle checkpoint is_a: GO:1901977 ! negative regulation of cell cycle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031577 ! spindle checkpoint relationship: negatively_regulates GO:0031577 ! spindle checkpoint created_by: tanyaberardini creation_date: 2010-01-20T10:29:43Z [Term] id: GO:0090234 name: regulation of kinetochore assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090230 ! regulation of centromere complex assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051382 ! kinetochore assembly relationship: regulates GO:0051382 ! kinetochore assembly created_by: tanyaberardini creation_date: 2010-01-20T10:46:56Z [Term] id: GO:0090235 name: regulation of metaphase plate congression namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051310 ! metaphase plate congression relationship: regulates GO:0051310 ! metaphase plate congression created_by: tanyaberardini creation_date: 2010-01-20T11:05:55Z [Term] id: GO:0090236 name: obsolete regulation of transcription from RNA polymerase II promoter involved in somitogenesis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: tanyaberardini creation_date: 2010-01-20T11:12:29Z [Term] id: GO:0090237 name: regulation of arachidonic acid secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:dph, GOC:tb] is_a: GO:0032303 ! regulation of icosanoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050482 ! arachidonic acid secretion relationship: regulates GO:0050482 ! arachidonic acid secretion created_by: tanyaberardini creation_date: 2010-01-20T03:32:22Z [Term] id: GO:0090238 name: positive regulation of arachidonic acid secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032305 ! positive regulation of icosanoid secretion is_a: GO:0090237 ! regulation of arachidonic acid secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050482 ! arachidonic acid secretion relationship: positively_regulates GO:0050482 ! arachidonic acid secretion created_by: tanyaberardini creation_date: 2010-01-20T03:32:22Z [Term] id: GO:0090239 name: regulation of histone H4 acetylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035065 ! regulation of histone acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043967 ! histone H4 acetylation relationship: regulates GO:0043967 ! histone H4 acetylation created_by: tanyaberardini creation_date: 2010-01-20T03:48:09Z [Term] id: GO:0090240 name: positive regulation of histone H4 acetylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:0090239 ! regulation of histone H4 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043967 ! histone H4 acetylation relationship: positively_regulates GO:0043967 ! histone H4 acetylation created_by: tanyaberardini creation_date: 2010-01-20T03:48:09Z [Term] id: GO:0090241 name: negative regulation of histone H4 acetylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:0090239 ! regulation of histone H4 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043967 ! histone H4 acetylation relationship: negatively_regulates GO:0043967 ! histone H4 acetylation created_by: tanyaberardini creation_date: 2010-01-20T03:48:09Z [Term] id: GO:0090242 name: retinoic acid receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "retinoic acid receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: GO:0048384 ! retinoic acid receptor signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T10:42:54Z [Term] id: GO:0090243 name: fibroblast growth factor receptor signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T10:46:15Z [Term] id: GO:0090244 name: Wnt signaling pathway involved in somitogenesis namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Wnt receptor signaling pathway involved in somitogenesis" EXACT [] synonym: "Wnt receptor signalling" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in somitogenesis" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T10:47:59Z [Term] id: GO:0090245 name: axis elongation involved in somitogenesis namespace: biological_process def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003401 ! axis elongation intersection_of: GO:0003401 ! axis elongation intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T10:54:29Z [Term] id: GO:0090246 name: convergent extension involved in somitogenesis namespace: biological_process def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060028 ! convergent extension involved in axis elongation intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T10:59:06Z [Term] id: GO:0090247 name: cell motility involved in somitogenic axis elongation namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: part_of GO:0090245 ! axis elongation involved in somitogenesis relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:07:17Z [Term] id: GO:0090248 name: cell migration involved in somitogenic axis elongation namespace: biological_process def: "The orderly movement of a presomitic mesoderm cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration is_a: GO:0090247 ! cell motility involved in somitogenic axis elongation intersection_of: GO:0016477 ! cell migration intersection_of: part_of GO:0090245 ! axis elongation involved in somitogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:13:59Z [Term] id: GO:0090249 name: regulation of cell motility involved in somitogenic axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0014807 ! regulation of somitogenesis is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation relationship: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation created_by: tanyaberardini creation_date: 2010-01-22T11:20:05Z [Term] id: GO:0090250 name: cell-cell adhesion involved in establishment of planar polarity namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules intersection_of: part_of GO:0001736 ! establishment of planar polarity relationship: part_of GO:0001736 ! establishment of planar polarity created_by: tanyaberardini creation_date: 2010-01-22T11:28:03Z [Term] id: GO:0090251 name: protein localization involved in establishment of planar polarity namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0001736 ! establishment of planar polarity relationship: part_of GO:0001736 ! establishment of planar polarity created_by: tanyaberardini creation_date: 2010-01-22T11:31:32Z [Term] id: GO:0090252 name: epithelium migration involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090132 ! epithelium migration intersection_of: GO:0090132 ! epithelium migration intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:40:46Z [Term] id: GO:0090253 name: convergent extension involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:40:46Z [Term] id: GO:0090254 name: cell elongation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0009886 ! post-embryonic animal morphogenesis intersection_of: GO:0009826 ! unidimensional cell growth intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:40:46Z [Term] id: GO:0090255 name: cell proliferation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:40:46Z [Term] id: GO:0090256 name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis created_by: tanyaberardini creation_date: 2010-01-22T11:40:46Z [Term] id: GO:0090257 name: regulation of muscle system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003012 ! muscle system process relationship: regulates GO:0003012 ! muscle system process created_by: tanyaberardini creation_date: 2010-02-03T11:48:13Z [Term] id: GO:0090258 name: negative regulation of mitochondrial fission namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb] synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000266 ! mitochondrial fission relationship: negatively_regulates GO:0000266 ! mitochondrial fission created_by: tanyaberardini creation_date: 2010-02-03T04:05:32Z [Term] id: GO:0090259 name: regulation of retinal ganglion cell axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031290 ! retinal ganglion cell axon guidance relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance created_by: tanyaberardini creation_date: 2010-02-03T04:13:59Z [Term] id: GO:0090260 name: negative regulation of retinal ganglion cell axon guidance namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf] comment: Note that growth cone collapse has been observed only in assays performed in vitro. synonym: "axon growth cone collapse" RELATED [] is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance is_a: GO:1902668 ! negative regulation of axon guidance intersection_of: GO:0048519 ! negative regulation of biological process intersection_of: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance created_by: tanyaberardini creation_date: 2010-02-03T04:13:59Z [Term] id: GO:0090261 name: positive regulation of inclusion body assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090083 ! regulation of inclusion body assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070841 ! inclusion body assembly relationship: positively_regulates GO:0070841 ! inclusion body assembly created_by: tanyaberardini creation_date: 2010-02-03T04:23:54Z [Term] id: GO:0090262 name: regulation of transcription-coupled nucleotide-excision repair namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb] is_a: GO:2000819 ! regulation of nucleotide-excision repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair created_by: tanyaberardini creation_date: 2010-02-03T04:27:42Z [Term] id: GO:0090263 name: positive regulation of canonical Wnt signaling pathway namespace: biological_process alt_id: GO:0035413 def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] synonym: "positive regulation of canonical Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "positive regulation of catenin import into nucleus" NARROW [] synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah] synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060070 ! canonical Wnt signaling pathway relationship: positively_regulates GO:0060070 ! canonical Wnt signaling pathway created_by: tanyaberardini creation_date: 2010-02-03T04:32:16Z [Term] id: GO:0090264 name: regulation of immune complex clearance by monocytes and macrophages namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages created_by: tanyaberardini creation_date: 2010-02-04T04:31:29Z [Term] id: GO:0090265 name: positive regulation of immune complex clearance by monocytes and macrophages namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages created_by: tanyaberardini creation_date: 2010-02-04T04:32:18Z [Term] id: GO:0090266 name: regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:1903504 ! regulation of mitotic spindle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007094 ! mitotic spindle assembly checkpoint relationship: regulates GO:0007094 ! mitotic spindle assembly checkpoint created_by: tanyaberardini creation_date: 2010-02-05T02:06:37Z [Term] id: GO:0090267 name: positive regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:0090232 ! positive regulation of spindle checkpoint is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint relationship: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint created_by: tanyaberardini creation_date: 2010-02-05T02:09:44Z [Term] id: GO:0090268 name: activation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw] is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint created_by: tanyaberardini creation_date: 2010-02-05T02:09:44Z [Term] id: GO:0090269 name: fibroblast growth factor production namespace: biological_process def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production created_by: tanyaberardini creation_date: 2010-02-05T02:33:33Z [Term] id: GO:0090270 name: regulation of fibroblast growth factor production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090269 ! fibroblast growth factor production relationship: regulates GO:0090269 ! fibroblast growth factor production created_by: tanyaberardini creation_date: 2010-02-05T02:33:33Z [Term] id: GO:0090271 name: positive regulation of fibroblast growth factor production namespace: biological_process def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0090270 ! regulation of fibroblast growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090269 ! fibroblast growth factor production relationship: positively_regulates GO:0090269 ! fibroblast growth factor production created_by: tanyaberardini creation_date: 2010-02-05T02:33:33Z [Term] id: GO:0090272 name: negative regulation of fibroblast growth factor production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0090270 ! regulation of fibroblast growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090269 ! fibroblast growth factor production relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production created_by: tanyaberardini creation_date: 2010-02-05T02:33:33Z [Term] id: GO:0090273 name: regulation of somatostatin secretion namespace: biological_process def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070253 ! somatostatin secretion relationship: regulates GO:0070253 ! somatostatin secretion created_by: tanyaberardini creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090274 name: positive regulation of somatostatin secretion namespace: biological_process def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070253 ! somatostatin secretion relationship: positively_regulates GO:0070253 ! somatostatin secretion created_by: tanyaberardini creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090275 name: negative regulation of somatostatin secretion namespace: biological_process def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] is_a: GO:0090273 ! regulation of somatostatin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070253 ! somatostatin secretion relationship: negatively_regulates GO:0070253 ! somatostatin secretion created_by: tanyaberardini creation_date: 2010-02-05T02:54:14Z [Term] id: GO:0090276 name: regulation of peptide hormone secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030072 ! peptide hormone secretion relationship: regulates GO:0030072 ! peptide hormone secretion created_by: tanyaberardini creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090277 name: positive regulation of peptide hormone secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030072 ! peptide hormone secretion relationship: positively_regulates GO:0030072 ! peptide hormone secretion created_by: tanyaberardini creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090278 name: negative regulation of peptide hormone secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030072 ! peptide hormone secretion relationship: negatively_regulates GO:0030072 ! peptide hormone secretion created_by: tanyaberardini creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090279 name: regulation of calcium ion import namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070509 ! calcium ion import relationship: regulates GO:0070509 ! calcium ion import created_by: tanyaberardini creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090280 name: positive regulation of calcium ion import namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "positive regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070509 ! calcium ion import relationship: positively_regulates GO:0070509 ! calcium ion import created_by: tanyaberardini creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090281 name: negative regulation of calcium ion import namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] synonym: "negative regulation of transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:0090279 ! regulation of calcium ion import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070509 ! calcium ion import relationship: negatively_regulates GO:0070509 ! calcium ion import created_by: tanyaberardini creation_date: 2010-02-08T05:11:20Z [Term] id: GO:0090282 name: positive regulation of transcription involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837] synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] synonym: "activation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn] synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" EXACT [GOC:rn] synonym: "up-regulation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn] is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle created_by: tanyaberardini creation_date: 2010-02-09T02:13:26Z [Term] id: GO:0090283 name: regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033578 ! protein glycosylation in Golgi relationship: regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090284 name: positive regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060050 ! positive regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090285 name: negative regulation of protein glycosylation in Golgi namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] is_a: GO:0060051 ! negative regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi created_by: tanyaberardini creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090286 name: cytoskeletal anchoring at nuclear membrane namespace: biological_process def: "The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell created_by: tanyaberardini creation_date: 2010-02-18T02:56:26Z [Term] id: GO:0090287 name: regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071363 ! cellular response to growth factor stimulus relationship: regulates GO:0071363 ! cellular response to growth factor stimulus created_by: tanyaberardini creation_date: 2010-02-18T03:01:25Z [Term] id: GO:0090288 name: negative regulation of cellular response to growth factor stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus created_by: tanyaberardini creation_date: 2010-02-18T03:01:25Z [Term] id: GO:0090289 name: regulation of osteoclast proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002158 ! osteoclast proliferation relationship: regulates GO:0002158 ! osteoclast proliferation created_by: tanyaberardini creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090290 name: positive regulation of osteoclast proliferation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002158 ! osteoclast proliferation relationship: positively_regulates GO:0002158 ! osteoclast proliferation created_by: tanyaberardini creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090291 name: negative regulation of osteoclast proliferation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002158 ! osteoclast proliferation relationship: negatively_regulates GO:0002158 ! osteoclast proliferation created_by: tanyaberardini creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090292 name: nuclear matrix anchoring at nuclear membrane namespace: biological_process def: "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb] synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb] is_a: GO:0043578 ! nuclear matrix organization is_a: GO:0051457 ! maintenance of protein location in nucleus created_by: tanyaberardini creation_date: 2010-02-22T03:05:13Z [Term] id: GO:0090293 name: nitrogen catabolite regulation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:0031670 ! cellular response to nutrient relationship: part_of GO:0071417 ! cellular response to organonitrogen compound created_by: tanyaberardini creation_date: 2010-02-24T02:31:53Z [Term] id: GO:0090294 name: nitrogen catabolite activation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "positive regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0090293 ! nitrogen catabolite regulation of transcription created_by: tanyaberardini creation_date: 2010-02-24T02:31:53Z [Term] id: GO:0090295 name: nitrogen catabolite repression of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] synonym: "negative regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] synonym: "nitrogen catabolite repression" EXACT [GOC:mah, GOC:rb] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0061984 ! catabolite repression is_a: GO:0090293 ! nitrogen catabolite regulation of transcription created_by: tanyaberardini creation_date: 2010-02-24T02:31:53Z [Term] id: GO:0090296 name: regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] synonym: "regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006264 ! mitochondrial DNA replication relationship: regulates GO:0006264 ! mitochondrial DNA replication created_by: tanyaberardini creation_date: 2010-03-12T03:58:25Z [Term] id: GO:0090297 name: positive regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] synonym: "positive regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] is_a: GO:0090296 ! regulation of mitochondrial DNA replication is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006264 ! mitochondrial DNA replication relationship: positively_regulates GO:0006264 ! mitochondrial DNA replication created_by: tanyaberardini creation_date: 2010-03-12T03:58:25Z [Term] id: GO:0090298 name: negative regulation of mitochondrial DNA replication namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] synonym: "negative regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] is_a: GO:0090296 ! regulation of mitochondrial DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006264 ! mitochondrial DNA replication relationship: negatively_regulates GO:0006264 ! mitochondrial DNA replication created_by: tanyaberardini creation_date: 2010-03-12T03:58:25Z [Term] id: GO:0090299 name: regulation of neural crest formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014029 ! neural crest formation relationship: regulates GO:0014029 ! neural crest formation created_by: tanyaberardini creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090300 name: positive regulation of neural crest formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014029 ! neural crest formation relationship: positively_regulates GO:0014029 ! neural crest formation created_by: tanyaberardini creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090301 name: negative regulation of neural crest formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014029 ! neural crest formation relationship: negatively_regulates GO:0014029 ! neural crest formation created_by: tanyaberardini creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090303 name: positive regulation of wound healing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042060 ! wound healing relationship: positively_regulates GO:0042060 ! wound healing created_by: tanyaberardini creation_date: 2010-03-22T02:12:03Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process created_by: tanyaberardini creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090305 name: nucleic acid phosphodiester bond hydrolysis namespace: biological_process def: "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb] is_a: GO:0090304 ! nucleic acid metabolic process created_by: tanyaberardini creation_date: 2010-04-07T10:26:30Z [Term] id: GO:0090306 name: spindle assembly involved in meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] synonym: "meiotic spindle assembly" EXACT [GOC:vw] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140013 ! meiotic nuclear division relationship: part_of GO:0140013 ! meiotic nuclear division created_by: tanyaberardini creation_date: 2010-04-09T11:21:56Z [Term] id: GO:0090307 name: mitotic spindle assembly namespace: biological_process def: "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] synonym: "spindle assembly involved in mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0140014 ! mitotic nuclear division relationship: part_of GO:0140014 ! mitotic nuclear division created_by: tanyaberardini creation_date: 2010-04-09T11:31:28Z [Term] id: GO:0090308 name: regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0031935 ! regulation of chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006346 ! methylation-dependent chromatin silencing relationship: regulates GO:0006346 ! methylation-dependent chromatin silencing created_by: tanyaberardini creation_date: 2010-04-09T02:12:53Z [Term] id: GO:0090309 name: positive regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006346 ! methylation-dependent chromatin silencing relationship: positively_regulates GO:0006346 ! methylation-dependent chromatin silencing created_by: tanyaberardini creation_date: 2010-04-09T02:12:53Z [Term] id: GO:0090310 name: negative regulation of methylation-dependent chromatin silencing namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0090308 ! regulation of methylation-dependent chromatin silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006346 ! methylation-dependent chromatin silencing relationship: negatively_regulates GO:0006346 ! methylation-dependent chromatin silencing created_by: tanyaberardini creation_date: 2010-04-09T02:12:53Z [Term] id: GO:0090311 name: regulation of protein deacetylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:tb] synonym: "regulation of protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006476 ! protein deacetylation relationship: regulates GO:0006476 ! protein deacetylation created_by: tanyaberardini creation_date: 2010-04-14T01:30:45Z [Term] id: GO:0090312 name: positive regulation of protein deacetylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ecd, PMID:20027304] synonym: "positive regulation of protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0090311 ! regulation of protein deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006476 ! protein deacetylation relationship: positively_regulates GO:0006476 ! protein deacetylation created_by: tanyaberardini creation_date: 2010-04-14T01:30:45Z [Term] id: GO:0090313 name: regulation of protein targeting to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:1903533 ! regulation of protein targeting is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006612 ! protein targeting to membrane relationship: regulates GO:0006612 ! protein targeting to membrane created_by: tanyaberardini creation_date: 2010-04-16T03:42:22Z [Term] id: GO:0090314 name: positive regulation of protein targeting to membrane namespace: biological_process def: "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:0090313 ! regulation of protein targeting to membrane is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006612 ! protein targeting to membrane relationship: positively_regulates GO:0006612 ! protein targeting to membrane created_by: tanyaberardini creation_date: 2010-04-16T03:42:22Z [Term] id: GO:0090315 name: negative regulation of protein targeting to membrane namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] is_a: GO:0090313 ! regulation of protein targeting to membrane is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006612 ! protein targeting to membrane relationship: negatively_regulates GO:0006612 ! protein targeting to membrane created_by: tanyaberardini creation_date: 2010-04-16T03:42:22Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006886 ! intracellular protein transport relationship: positively_regulates GO:0006886 ! intracellular protein transport created_by: tanyaberardini creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport created_by: tanyaberardini creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090318 name: regulation of chylomicron remodeling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034371 ! chylomicron remodeling relationship: regulates GO:0034371 ! chylomicron remodeling created_by: tanyaberardini creation_date: 2010-04-30T10:09:08Z [Term] id: GO:0090319 name: positive regulation of chylomicron remodeling namespace: biological_process def: "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090318 ! regulation of chylomicron remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034371 ! chylomicron remodeling relationship: positively_regulates GO:0034371 ! chylomicron remodeling created_by: tanyaberardini creation_date: 2010-04-30T10:09:08Z [Term] id: GO:0090320 name: regulation of chylomicron remnant clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034382 ! chylomicron remnant clearance relationship: regulates GO:0034382 ! chylomicron remnant clearance created_by: tanyaberardini creation_date: 2010-04-30T10:20:26Z [Term] id: GO:0090321 name: positive regulation of chylomicron remnant clearance namespace: biological_process def: "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF] is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance is_a: GO:0090320 ! regulation of chylomicron remnant clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034382 ! chylomicron remnant clearance relationship: positively_regulates GO:0034382 ! chylomicron remnant clearance created_by: tanyaberardini creation_date: 2010-04-30T10:20:26Z [Term] id: GO:0090322 name: regulation of superoxide metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb] synonym: "regulation of superoxide metabolism" EXACT [GOC:tb] is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006801 ! superoxide metabolic process relationship: regulates GO:0006801 ! superoxide metabolic process created_by: tanyaberardini creation_date: 2010-05-06T02:29:05Z [Term] id: GO:0090323 name: prostaglandin secretion involved in immune response namespace: biological_process def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb] is_a: GO:0002440 ! production of molecular mediator of immune response is_a: GO:0032310 ! prostaglandin secretion intersection_of: GO:0032310 ! prostaglandin secretion intersection_of: part_of GO:0006955 ! immune response relationship: part_of GO:0006955 ! immune response created_by: tanyaberardini creation_date: 2010-05-12T10:41:04Z [Term] id: GO:0090324 name: negative regulation of oxidative phosphorylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:BHF] is_a: GO:0002082 ! regulation of oxidative phosphorylation is_a: GO:0042326 ! negative regulation of phosphorylation is_a: GO:1903579 ! negative regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006119 ! oxidative phosphorylation relationship: negatively_regulates GO:0006119 ! oxidative phosphorylation created_by: tanyaberardini creation_date: 2010-05-14T10:21:33Z [Term] id: GO:0090325 name: regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:24:29Z [Term] id: GO:0090326 name: positive regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090327 name: negative regulation of locomotion involved in locomotory behavior namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior created_by: tanyaberardini creation_date: 2010-05-14T10:26:58Z [Term] id: GO:0090328 name: regulation of olfactory learning namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008355 ! olfactory learning relationship: regulates GO:0008355 ! olfactory learning created_by: tanyaberardini creation_date: 2010-05-14T10:37:22Z [Term] id: GO:0090329 name: regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:dph, GOC:tb] is_a: GO:0006275 ! regulation of DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006261 ! DNA-dependent DNA replication relationship: regulates GO:0006261 ! DNA-dependent DNA replication created_by: tanyaberardini creation_date: 2010-05-14T10:42:04Z [Term] id: GO:0090330 name: regulation of platelet aggregation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070527 ! platelet aggregation relationship: regulates GO:0070527 ! platelet aggregation created_by: tanyaberardini creation_date: 2010-05-14T10:46:08Z [Term] id: GO:0090331 name: negative regulation of platelet aggregation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF] synonym: "platelet disaggregation" NARROW [GOC:dph, PMID:12871378] is_a: GO:0010544 ! negative regulation of platelet activation is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion is_a: GO:0090330 ! regulation of platelet aggregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070527 ! platelet aggregation relationship: negatively_regulates GO:0070527 ! platelet aggregation created_by: tanyaberardini creation_date: 2010-05-14T10:46:08Z [Term] id: GO:0090332 name: stomatal closure namespace: biological_process def: "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] is_a: GO:0010118 ! stomatal movement created_by: tanyaberardini creation_date: 2010-05-26T02:14:49Z [Term] id: GO:0090333 name: regulation of stomatal closure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] is_a: GO:0010119 ! regulation of stomatal movement relationship: regulates GO:0090332 ! stomatal closure created_by: tanyaberardini creation_date: 2010-05-26T02:14:49Z [Term] id: GO:0090334 name: regulation of cell wall (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:tb] synonym: "regulation of cell wall 1,3-beta-D-glucan biosynthetic process" BROAD [] synonym: "regulation of cell wall 1,3-beta-glucan biosynthetic process" BROAD [] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process relationship: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process created_by: tanyaberardini creation_date: 2010-06-01T03:11:34Z [Term] id: GO:0090335 name: regulation of brown fat cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb] is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050873 ! brown fat cell differentiation relationship: regulates GO:0050873 ! brown fat cell differentiation created_by: tanyaberardini creation_date: 2010-06-01T03:16:57Z [Term] id: GO:0090336 name: positive regulation of brown fat cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF] is_a: GO:0045600 ! positive regulation of fat cell differentiation is_a: GO:0090335 ! regulation of brown fat cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050873 ! brown fat cell differentiation relationship: positively_regulates GO:0050873 ! brown fat cell differentiation created_by: tanyaberardini creation_date: 2010-06-01T03:19:26Z [Term] id: GO:0090337 name: regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032231 ! regulation of actin filament bundle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070649 ! formin-nucleated actin cable assembly relationship: regulates GO:0070649 ! formin-nucleated actin cable assembly created_by: tanyaberardini creation_date: 2010-06-01T03:26:31Z [Term] id: GO:0090338 name: positive regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032233 ! positive regulation of actin filament bundle assembly is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly relationship: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly created_by: tanyaberardini creation_date: 2010-06-01T03:26:31Z [Term] id: GO:0090339 name: negative regulation of formin-nucleated actin cable assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] is_a: GO:0032232 ! negative regulation of actin filament bundle assembly is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly relationship: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly created_by: tanyaberardini creation_date: 2010-06-01T03:26:31Z [Term] id: GO:0090340 name: positive regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033299 ! secretion of lysosomal enzymes relationship: positively_regulates GO:0033299 ! secretion of lysosomal enzymes created_by: tanyaberardini creation_date: 2010-06-01T03:35:57Z [Term] id: GO:0090341 name: negative regulation of secretion of lysosomal enzymes namespace: biological_process def: "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes relationship: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes created_by: tanyaberardini creation_date: 2010-06-01T03:35:57Z [Term] id: GO:0090342 name: regulation of cell aging namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007569 ! cell aging relationship: regulates GO:0007569 ! cell aging created_by: tanyaberardini creation_date: 2010-06-02T10:12:37Z [Term] id: GO:0090343 name: positive regulation of cell aging namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090342 ! regulation of cell aging intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007569 ! cell aging relationship: positively_regulates GO:0007569 ! cell aging created_by: tanyaberardini creation_date: 2010-06-02T10:12:37Z [Term] id: GO:0090344 name: negative regulation of cell aging namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090342 ! regulation of cell aging intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007569 ! cell aging relationship: negatively_regulates GO:0007569 ! cell aging created_by: tanyaberardini creation_date: 2010-06-02T10:12:37Z [Term] id: GO:0090345 name: cellular organohalogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0044237 ! cellular metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090346 name: cellular organofluorine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090345 ! cellular organohalogen metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090347 name: regulation of cellular organohalogen metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090345 ! cellular organohalogen metabolic process relationship: regulates GO:0090345 ! cellular organohalogen metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090348 name: regulation of cellular organofluorine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090346 ! cellular organofluorine metabolic process relationship: regulates GO:0090346 ! cellular organofluorine metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090349 name: negative regulation of cellular organohalogen metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process relationship: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090350 name: negative regulation of cellular organofluorine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] is_a: GO:0090348 ! regulation of cellular organofluorine metabolic process is_a: GO:0090349 ! negative regulation of cellular organohalogen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process relationship: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process created_by: tanyaberardini creation_date: 2010-06-02T10:36:42Z [Term] id: GO:0090351 name: seedling development namespace: biological_process def: "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge." [GOC:tb, PO:0007131] xref: PO:0008037 is_a: GO:0009791 ! post-embryonic development created_by: tanyaberardini creation_date: 2010-06-10T03:33:10Z [Term] id: GO:0090352 name: regulation of nitrate assimilation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042128 ! nitrate assimilation relationship: regulates GO:0042128 ! nitrate assimilation created_by: tanyaberardini creation_date: 2010-06-10T04:11:13Z [Term] id: GO:0090353 name: polygalacturonase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a polygalacturonase. Polygalacturonases catalyze the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity created_by: tanyaberardini creation_date: 2010-06-15T04:19:49Z [Term] id: GO:0090354 name: regulation of auxin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009850 ! auxin metabolic process relationship: regulates GO:0009850 ! auxin metabolic process created_by: tanyaberardini creation_date: 2010-06-29T01:51:18Z [Term] id: GO:0090355 name: positive regulation of auxin metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "positive regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0090354 ! regulation of auxin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009850 ! auxin metabolic process relationship: positively_regulates GO:0009850 ! auxin metabolic process created_by: tanyaberardini creation_date: 2010-06-29T01:51:18Z [Term] id: GO:0090356 name: negative regulation of auxin metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] synonym: "negative regulation of auxin metabolism" EXACT [GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0090354 ! regulation of auxin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009850 ! auxin metabolic process relationship: negatively_regulates GO:0009850 ! auxin metabolic process created_by: tanyaberardini creation_date: 2010-06-29T01:51:18Z [Term] id: GO:0090357 name: regulation of tryptophan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] synonym: "regulation of tryptophan metabolism" EXACT [GOC:tb] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006568 ! tryptophan metabolic process relationship: regulates GO:0006568 ! tryptophan metabolic process created_by: tanyaberardini creation_date: 2010-06-29T02:38:48Z [Term] id: GO:0090358 name: positive regulation of tryptophan metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] synonym: "positive regulation of tryptophan metabolism" EXACT [GOC:tb] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0090357 ! regulation of tryptophan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006568 ! tryptophan metabolic process relationship: positively_regulates GO:0006568 ! tryptophan metabolic process created_by: tanyaberardini creation_date: 2010-06-29T02:38:48Z [Term] id: GO:0090359 name: negative regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:tb] synonym: "negative regulation of abscisic acid biosynthesis" EXACT [GOC:tb] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process relationship: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process created_by: tanyaberardini creation_date: 2010-06-29T02:47:12Z [Term] id: GO:0090360 name: platelet-derived growth factor production namespace: biological_process def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001816 ! cytokine production created_by: tanyaberardini creation_date: 2010-07-12T10:32:27Z [Term] id: GO:0090361 name: regulation of platelet-derived growth factor production namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090360 ! platelet-derived growth factor production relationship: regulates GO:0090360 ! platelet-derived growth factor production created_by: tanyaberardini creation_date: 2010-07-12T10:32:27Z [Term] id: GO:0090362 name: positive regulation of platelet-derived growth factor production namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0090361 ! regulation of platelet-derived growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090360 ! platelet-derived growth factor production relationship: positively_regulates GO:0090360 ! platelet-derived growth factor production created_by: tanyaberardini creation_date: 2010-07-12T10:32:27Z [Term] id: GO:0090363 name: regulation of proteasome core complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [GOC:dph, GOC:elh, GOC:tb] is_a: GO:0090364 ! regulation of proteasome assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080129 ! proteasome core complex assembly relationship: regulates GO:0080129 ! proteasome core complex assembly created_by: tanyaberardini creation_date: 2010-07-12T10:48:57Z [Term] id: GO:0090364 name: regulation of proteasome assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043248 ! proteasome assembly relationship: regulates GO:0043248 ! proteasome assembly created_by: tanyaberardini creation_date: 2010-07-12T10:55:21Z [Term] id: GO:0090365 name: regulation of mRNA modification namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb, PMID:14559896] synonym: "regulation of mRNA editing" NARROW [] is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016556 ! mRNA modification relationship: regulates GO:0016556 ! mRNA modification created_by: tanyaberardini creation_date: 2010-07-12T11:04:45Z [Term] id: GO:0090366 name: positive regulation of mRNA modification namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0090365 ! regulation of mRNA modification is_a: GO:1903313 ! positive regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016556 ! mRNA modification relationship: positively_regulates GO:0016556 ! mRNA modification created_by: tanyaberardini creation_date: 2010-07-12T11:04:45Z [Term] id: GO:0090367 name: negative regulation of mRNA modification namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0090365 ! regulation of mRNA modification is_a: GO:1903312 ! negative regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016556 ! mRNA modification relationship: negatively_regulates GO:0016556 ! mRNA modification created_by: tanyaberardini creation_date: 2010-07-12T11:04:45Z [Term] id: GO:0090368 name: regulation of ornithine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006591 ! ornithine metabolic process relationship: regulates GO:0006591 ! ornithine metabolic process created_by: tanyaberardini creation_date: 2010-07-12T11:14:12Z [Term] id: GO:0090369 name: ornithine carbamoyltransferase inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces ornithine carbamoyltransferase activity, the catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004585 ! ornithine carbamoyltransferase activity relationship: part_of GO:0090368 ! regulation of ornithine metabolic process created_by: tanyaberardini creation_date: 2010-07-12T11:19:55Z [Term] id: GO:0090370 name: negative regulation of cholesterol efflux namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:dph, GOC:tb, GOC:yaf] is_a: GO:0010874 ! regulation of cholesterol efflux is_a: GO:0032375 ! negative regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033344 ! cholesterol efflux relationship: negatively_regulates GO:0033344 ! cholesterol efflux created_by: tanyaberardini creation_date: 2010-07-12T11:26:04Z [Term] id: GO:0090371 name: regulation of glycerol transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015793 ! glycerol transport relationship: regulates GO:0015793 ! glycerol transport created_by: tanyaberardini creation_date: 2010-07-12T11:30:22Z [Term] id: GO:0090372 name: positive regulation of glycerol transport namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0090371 ! regulation of glycerol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015793 ! glycerol transport relationship: positively_regulates GO:0015793 ! glycerol transport created_by: tanyaberardini creation_date: 2010-07-12T11:30:22Z [Term] id: GO:0090373 name: negative regulation of glycerol transport namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0090371 ! regulation of glycerol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015793 ! glycerol transport relationship: negatively_regulates GO:0015793 ! glycerol transport created_by: tanyaberardini creation_date: 2010-07-12T11:30:22Z [Term] id: GO:0090374 name: oligopeptide export from mitochondrion namespace: biological_process def: "The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: tanyaberardini creation_date: 2010-08-27T04:38:18Z [Term] id: GO:0090375 name: negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:tb] synonym: "negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:tb] is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress created_by: tanyaberardini creation_date: 2010-09-01T01:22:23Z [Term] id: GO:0090376 name: seed trichome differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function." [GOC:tb, PMID:17905721] synonym: "cotton fiber development" NARROW [GOC:tb] synonym: "seed hair differentiation" EXACT [PO:0004511] synonym: "seed trichome development" RELATED [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010026 ! trichome differentiation is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048316 ! seed development created_by: tanyaberardini creation_date: 2010-09-15T02:07:10Z [Term] id: GO:0090377 name: seed trichome initiation namespace: biological_process def: "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis." [PMID:17905721] comment: These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp. synonym: "seed trichome fate commitment" EXACT [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0090376 ! seed trichome differentiation created_by: tanyaberardini creation_date: 2010-09-15T02:13:59Z [Term] id: GO:0090378 name: seed trichome elongation namespace: biological_process def: "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [GOC:tb] comment: The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0090376 ! seed trichome differentiation created_by: tanyaberardini creation_date: 2010-09-15T02:20:47Z [Term] id: GO:0090379 name: secondary cell wall biogenesis involved in seed trichome differentiation namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete." [GOC:tb] comment: The processes involved in the massive amount of secondary wall cellulose synthesis in seed trichomes continue to 30 DPA in Gossypium spp. synonym: "secondary cell wall biosynthesis involved in seed trichome differentiation" EXACT [GOC:tb] synonym: "seed trichome secondary wall biosynthesis" RELATED [GOC:tb] is_a: GO:0009834 ! plant-type secondary cell wall biogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism intersection_of: GO:0009834 ! plant-type secondary cell wall biogenesis intersection_of: part_of GO:0090376 ! seed trichome differentiation relationship: part_of GO:0090376 ! seed trichome differentiation created_by: tanyaberardini creation_date: 2010-09-15T02:24:34Z [Term] id: GO:0090380 name: seed trichome maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state." [GOC:tb] comment: These processes continue to 60 DPA in Gossypium spp. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0090376 ! seed trichome differentiation created_by: tanyaberardini creation_date: 2010-09-15T02:29:42Z [Term] id: GO:0090381 name: regulation of heart induction namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:dph, GOC:tb] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003129 ! heart induction relationship: regulates GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2010-10-04T10:23:43Z [Term] id: GO:0090382 name: phagosome maturation namespace: biological_process def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] is_a: GO:0006996 ! organelle organization created_by: tanyaberardini creation_date: 2010-10-19T11:10:34Z [Term] id: GO:0090383 name: phagosome acidification namespace: biological_process def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion." [GOC:kmv, GOC:tb] synonym: "phagosomal acidification" EXACT [GOC:kmv, GOC:tb] is_a: GO:0051452 ! intracellular pH reduction relationship: part_of GO:0090382 ! phagosome maturation created_by: tanyaberardini creation_date: 2010-10-27T10:20:22Z [Term] id: GO:0090384 name: phagosome-lysosome docking namespace: biological_process def: "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] synonym: "lysosome recruitment to phagosome" EXACT [GOC:kmv, GOC:tb] is_a: GO:0048278 ! vesicle docking relationship: part_of GO:0001845 ! phagolysosome assembly created_by: tanyaberardini creation_date: 2010-10-27T10:24:28Z [Term] id: GO:0090385 name: phagosome-lysosome fusion namespace: biological_process def: "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0001845 ! phagolysosome assembly created_by: tanyaberardini creation_date: 2010-10-27T10:24:28Z [Term] id: GO:0090386 name: phagosome maturation involved in apoptotic cell clearance namespace: biological_process def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] is_a: GO:0090382 ! phagosome maturation intersection_of: GO:0090382 ! phagosome maturation intersection_of: part_of GO:0043277 ! apoptotic cell clearance relationship: part_of GO:0043277 ! apoptotic cell clearance created_by: tanyaberardini creation_date: 2010-10-27T10:57:39Z [Term] id: GO:0090387 name: phagolysosome assembly involved in apoptotic cell clearance namespace: biological_process def: "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0001845 ! phagolysosome assembly intersection_of: GO:0001845 ! phagolysosome assembly intersection_of: part_of GO:0043277 ! apoptotic cell clearance relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance created_by: tanyaberardini creation_date: 2010-10-27T10:57:39Z [Term] id: GO:0090388 name: phagosome-lysosome docking involved in apoptotic cell clearance namespace: biological_process def: "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] is_a: GO:0090384 ! phagosome-lysosome docking intersection_of: GO:0090384 ! phagosome-lysosome docking intersection_of: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance created_by: tanyaberardini creation_date: 2010-10-27T10:57:39Z [Term] id: GO:0090389 name: phagosome-lysosome fusion involved in apoptotic cell clearance namespace: biological_process def: "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0090385 ! phagosome-lysosome fusion intersection_of: GO:0090385 ! phagosome-lysosome fusion intersection_of: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance created_by: tanyaberardini creation_date: 2010-10-27T10:57:39Z [Term] id: GO:0090390 name: phagosome acidification involved in apoptotic cell clearance namespace: biological_process def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] is_a: GO:0090383 ! phagosome acidification intersection_of: GO:0090383 ! phagosome acidification intersection_of: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance created_by: tanyaberardini creation_date: 2010-10-27T10:57:39Z [Term] id: GO:0090391 name: granum assembly namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts." [GOC:tb] synonym: "grana formation" EXACT [GOC:tb] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0009658 ! chloroplast organization created_by: tanyaberardini creation_date: 2010-12-08T04:25:46Z [Term] id: GO:0090392 name: sepal giant cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C." [GOC:tb, PMID:20485493] is_a: GO:0090627 ! plant epidermal cell differentiation created_by: tanyaberardini creation_date: 2010-12-14T04:38:06Z [Term] id: GO:0090393 name: sepal giant cell development namespace: biological_process def: "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:tb] synonym: "sepal giant cell formation" RELATED [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0090392 ! sepal giant cell differentiation created_by: tanyaberardini creation_date: 2010-12-14T04:44:34Z [Term] id: GO:0090394 name: negative regulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF] synonym: "negative regulation of EPSP" RELATED [] synonym: "negative regulation of excitatory post-synaptic membrane potential" EXACT [] synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: negatively_regulates GO:0060079 ! excitatory postsynaptic potential relationship: negatively_regulates GO:0060079 ! excitatory postsynaptic potential created_by: tanyaberardini creation_date: 2010-12-15T01:43:12Z [Term] id: GO:0090395 name: plant cell papilla namespace: cellular_component def: "A cell projection that is a short, rounded projection from a plant epidermal cell." [GOC:tb] comment: Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001). is_a: GO:0042995 ! cell projection created_by: tanyaberardini creation_date: 2010-12-15T03:26:20Z [Term] id: GO:0090396 name: leaf papilla namespace: cellular_component def: "A plant cell papilla that is part of a leaf papilla cell." [GOC:tb] comment: Part of leaf papilla cell (PO:0025167). is_a: GO:0090395 ! plant cell papilla created_by: tanyaberardini creation_date: 2010-12-15T03:26:20Z [Term] id: GO:0090397 name: stigma papilla namespace: cellular_component def: "A plant cell papilla that is part of a stigma papilla cell." [GOC:tb] comment: Part of stigma papilla cell (PO:0025168). is_a: GO:0090395 ! plant cell papilla created_by: tanyaberardini creation_date: 2010-12-15T03:26:20Z [Term] id: GO:0090398 name: cellular senescence namespace: biological_process def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF] is_a: GO:0007569 ! cell aging is_a: GO:0033554 ! cellular response to stress created_by: tanyaberardini creation_date: 2011-01-05T02:27:08Z [Term] id: GO:0090399 name: replicative senescence namespace: biological_process def: "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." [GOC:BHF] is_a: GO:0007569 ! cell aging created_by: tanyaberardini creation_date: 2011-01-05T02:32:29Z [Term] id: GO:0090400 name: stress-induced premature senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays." [GOC:BHF] synonym: "SIPS" EXACT [GOC:BHF] is_a: GO:0090398 ! cellular senescence created_by: tanyaberardini creation_date: 2011-01-05T02:32:29Z [Term] id: GO:0090401 name: obsolete viral-induced premature senescence namespace: biological_process def: "OBSOLETE. A cellular senescence process associated with the dismantling of a cell as a response to viral infection." [GOC:BHF] comment: The reason for obsoletion is that it is not clear what the term is meant to be used for; there are no annotations and no references. There is nothing in the literature that mentions this process; there are papers that mention viral proteins overcoming premature senescence, for example, PMID:22326283. is_obsolete: true created_by: tanyaberardini creation_date: 2011-01-05T02:37:57Z [Term] id: GO:0090402 name: oncogene-induced cell senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family." [GOC:BHF] synonym: "OIS" EXACT [GOC:BHF] is_a: GO:0090398 ! cellular senescence created_by: tanyaberardini creation_date: 2011-01-05T02:37:57Z [Term] id: GO:0090403 name: oxidative stress-induced premature senescence namespace: biological_process def: "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals." [GOC:BHF] is_a: GO:0090400 ! stress-induced premature senescence relationship: part_of GO:0034599 ! cellular response to oxidative stress created_by: tanyaberardini creation_date: 2011-01-05T02:37:57Z [Term] id: GO:0090404 name: pollen tube tip namespace: cellular_component def: "The region at growing end of the pollen tube cell, where polarized growth occurs." [GOC:tb, PO:0025195, PO:0025281] is_a: GO:0035838 ! growing cell tip relationship: part_of GO:0090406 ! pollen tube created_by: tanyaberardini creation_date: 2011-01-10T10:25:58Z [Term] id: GO:0090405 name: unicellular trichome branch namespace: cellular_component def: "A cell projection part that is a branch of a unicellular trichome." [GOC:tb, PO:0025537] comment: Unicellular trichome (PO:0025537) is a trichome(PO:0000282) that is a single plant cell (PO:0009002). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163). is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0090552 ! unicellular trichome apex relationship: part_of GO:0042995 ! cell projection created_by: tanyaberardini creation_date: 2011-01-10T10:30:39Z [Term] id: GO:0090406 name: pollen tube namespace: cellular_component def: "A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain." [GOC:tb, PO:0025195, PO:0025281] comment: Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195). is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: tanyaberardini creation_date: 2011-01-10T01:59:40Z [Term] id: GO:0090407 name: organophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: tanyaberardini creation_date: 2011-02-26T02:22:41Z [Term] id: GO:0090408 name: phloem nitrate loading namespace: biological_process def: "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:tb] is_a: GO:0015706 ! nitrate transport is_a: GO:0110126 ! phloem loading created_by: tanyaberardini creation_date: 2011-06-01T10:06:21Z [Term] id: GO:0090409 name: malonyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate." [MetaCyc:RXN-12359] xref: EC:6.2.1.n3 xref: MetaCyc:RXN-12359 xref: RHEA:32139 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity created_by: tanyaberardini creation_date: 2011-06-10T01:51:16Z [Term] id: GO:0090410 name: malonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion." [GOC:tb] is_a: GO:0043649 ! dicarboxylic acid catabolic process created_by: tanyaberardini creation_date: 2011-06-10T01:53:43Z [Term] id: GO:0090411 name: brassinosteroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a brassinosteroid." [GOC:tb] is_a: GO:0005496 ! steroid binding created_by: tanyaberardini creation_date: 2011-08-11T02:25:30Z [Term] id: GO:0090412 name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process namespace: biological_process def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2011-09-01T03:10:41Z [Term] id: GO:0090413 name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process namespace: biological_process def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT [] is_obsolete: true created_by: tanyaberardini creation_date: 2011-09-01T03:10:41Z [Term] id: GO:0090414 name: molybdate ion export from vacuole namespace: biological_process def: "The directed movement of molybdate ions out of the vacuole." [GOC:tb] is_a: GO:0015689 ! molybdate ion transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: tanyaberardini creation_date: 2011-09-15T02:08:43Z [Term] id: GO:0090415 name: 7-hydroxymethyl chlorophyll a reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O." [GOC:kad, PMID:21934147] is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor created_by: tanyaberardini creation_date: 2011-10-03T12:08:27Z [Term] id: GO:0090416 name: nicotinate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nicotinate from one side of a membrane to the other." [GOC:tb] xref: Reactome:R-HSA-8869603 "SLC22A13 transports NCA from extracellular region to cytosol" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:2001142 ! nicotinate transport created_by: tanyaberardini creation_date: 2011-10-19T11:09:59Z [Term] id: GO:0090417 name: N-methylnicotinate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of N-methylnicotinate from one side of a membrane to the other." [GOC:tb] synonym: "N-methylnicotinate transporter activity" RELATED [] is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity relationship: part_of GO:2001143 ! N-methylnicotinate transport created_by: tanyaberardini creation_date: 2011-10-19T11:09:59Z [Term] id: GO:0090418 name: obsolete positive regulation of transcription involved in S-phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle." [PMID:16912276] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "activation of S phase specific transcription in the mitotic cell cycle" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] synonym: "activation of transcription involved in S phase of mitotic cell cycle" RELATED [] synonym: "positive regulation of S phase specific transcription in the mitotic cell cycle" RELATED [] synonym: "positive regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] synonym: "positive regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] synonym: "up-regulation of S phase specific transcription in the mitotic cell cycle" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] synonym: "up-regulation of transcription involved in S phase of mitotic cell cycle" RELATED [] is_obsolete: true created_by: tanyaberardini creation_date: 2011-10-26T03:54:00Z [Term] id: GO:0090419 name: negative regulation of transcription involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:10747051] synonym: "down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle" RELATED [] synonym: "negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" RELATED [] is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle created_by: tanyaberardini creation_date: 2011-10-26T03:59:41Z [Term] id: GO:0090420 name: naphthalene-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving naphthalene-containing compounds." [GOC:dph, GOC:tb] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: tanyaberardini creation_date: 2011-12-12T11:32:34Z [Term] id: GO:0090421 name: embryonic meristem initiation namespace: biological_process def: "Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:tb] is_a: GO:0010014 ! meristem initiation created_by: tanyaberardini creation_date: 2012-04-13T02:52:34Z [Term] id: GO:0090422 name: thiamine pyrophosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other." [GOC:tb] synonym: "thiamine diphosphate transporter activity" EXACT [GOC:tb] synonym: "thiamine pyrophosphate transporter activity" NARROW [] xref: Reactome:R-HSA-8875838 "SLC25A19 transports ThDP from cytosol to mitochondrial matrix" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0030974 ! thiamine pyrophosphate transmembrane transport created_by: tanyaberardini creation_date: 2012-04-17T12:28:11Z [Term] id: GO:0090423 name: phytochelatin-metal complex formation namespace: biological_process def: "A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex." [GOC:tb] synonym: "low molecular weight phytochelatin complex formation" RELATED [] synonym: "LWM phytochelatin complex formation" RELATED [] is_a: GO:0046937 ! phytochelatin metabolic process created_by: tanyaberardini creation_date: 2012-04-20T03:46:45Z [Term] id: GO:0090424 name: phytochelatin-metal-sulfur complex formation namespace: biological_process def: "A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex." [GOC:tb] synonym: "high molecular weight phytochelatin complex formation" RELATED [] synonym: "HWM phytochelatin complex formation" RELATED [] is_a: GO:0046937 ! phytochelatin metabolic process created_by: tanyaberardini creation_date: 2012-04-20T03:46:45Z [Term] id: GO:0090425 name: acinar cell differentiation namespace: biological_process def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] is_a: GO:0002067 ! glandular epithelial cell differentiation created_by: tanyaberardini creation_date: 2012-05-04T09:24:48Z [Term] id: GO:0090426 name: actin filament bundle convergence namespace: biological_process def: "A process of actin filament bundle distribution that results in the compaction of actin filaments." [GOC:dph, GOC:tb] is_a: GO:0070650 ! actin filament bundle distribution created_by: tanyaberardini creation_date: 2012-05-04T09:33:09Z [Term] id: GO:0090427 name: activation of meiosis namespace: biological_process def: "Any process that starts the inactive process of meiosis." [GOC:dph, GOC:tb] is_a: GO:0045836 ! positive regulation of meiotic nuclear division created_by: tanyaberardini creation_date: 2012-05-04T09:50:19Z [Term] id: GO:0090428 name: perianth development namespace: biological_process def: "The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals." [GOC:tb, PO:0009058] is_a: GO:0048438 ! floral whorl development created_by: tanyaberardini creation_date: 2012-05-08T06:02:15Z [Term] id: GO:0090429 name: detection of endogenous biotic stimulus namespace: biological_process def: "The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal." [GOC:dph, GOC:tb] is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009726 ! detection of endogenous stimulus created_by: tanyaberardini creation_date: 2012-05-11T09:19:39Z [Term] id: GO:0090430 name: caffeoyl-CoA: alcohol caffeoyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA." [GOC:pz] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: tanyaberardini creation_date: 2012-07-25T10:48:15Z [Term] id: GO:0090431 name: alkyl caffeate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate." [GOC:pz] synonym: "alkyl caffeate ester anabolism" EXACT [GOC:tb] synonym: "alkyl caffeate ester biosynthesis" EXACT [GOC:tb] synonym: "alkyl caffeate ester formation" EXACT [GOC:tb] synonym: "alkyl caffeate ester synthesis" EXACT [GOC:tb] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0009802 ! cinnamic acid ester biosynthetic process created_by: tanyaberardini creation_date: 2012-07-25T11:12:09Z [Term] id: GO:0090432 name: myristoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA." [GOC:al, PMID:18071249] synonym: "myristoyl-CoA synthetase activity" EXACT [] is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090433 name: palmitoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA." [GOC:al, PMID:18071249] synonym: "palmitoyl-CoA synthetase activity" EXACT [] xref: Reactome:R-HSA-434382 "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell" is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090434 name: oleoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA." [GOC:al, PMID:18071249] synonym: "oleoyl-CoA synthetase activity" EXACT [] is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090435 name: protein localization to nuclear envelope namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] synonym: "protein localization in nuclear envelope" EXACT [] is_a: GO:0034504 ! protein localization to nucleus created_by: tanyaberardini creation_date: 2012-07-30T01:50:41Z [Term] id: GO:0090436 name: leaf pavement cell development namespace: biological_process def: "The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate." [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0048366 ! leaf development created_by: tanyaberardini creation_date: 2012-07-31T16:08:53Z [Term] id: GO:0090437 name: socket cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support." [GOC:tb] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0090558 ! plant epidermis development created_by: tanyaberardini creation_date: 2012-07-31T17:01:28Z [Term] id: GO:0090438 name: camelliol C synthase activity namespace: molecular_function def: "Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C." [GOC:tb, PMID:17985917] synonym: "(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)" EXACT [] is_a: GO:0016866 ! intramolecular transferase activity created_by: tanyaberardini creation_date: 2012-08-08T15:41:45Z [Term] id: GO:0090439 name: tetraketide alpha-pyrone synthase activity namespace: molecular_function def: "Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ." [MetaCyc:RXN-12183, PMID:21193570] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: tanyaberardini creation_date: 2012-08-09T14:35:06Z [Term] id: GO:0090440 name: abscisic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of abscisic acid from one side of a membrane to the other." [GOC:tb] synonym: "abscisic acid transporter activity" EXACT [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity relationship: part_of GO:0080168 ! abscisic acid transport created_by: tanyaberardini creation_date: 2012-08-20T14:29:42Z [Term] id: GO:0090441 name: trehalose biosynthesis in response to heat stress namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb] synonym: "trehalose biosynthetic process in response to heat stress" EXACT systematic_synonym [GOC:tb] is_a: GO:0005992 ! trehalose biosynthetic process is_a: GO:0070414 ! trehalose metabolism in response to heat stress created_by: tanyaberardini creation_date: 2012-08-23T13:53:07Z [Term] id: GO:0090442 name: trehalose catabolism in response to heat stress namespace: biological_process def: "The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb] synonym: "trehalose catabolic process in response to heat stress" EXACT systematic_synonym [GOC:tb] is_a: GO:0070414 ! trehalose metabolism in response to heat stress is_a: GO:1903134 ! trehalose catabolic process involved in cellular response to stress created_by: tanyaberardini creation_date: 2012-08-23T13:53:07Z [Term] id: GO:0090443 name: FAR/SIN/STRIPAK complex namespace: cellular_component def: "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525] synonym: "FAR complex" RELATED [GOC:vw] synonym: "SIP complex" EXACT [PMID:22119525] synonym: "striatin interacting phosphatase and kinase complex" EXACT [GOC:vw] synonym: "STRIPAK signalling complex" RELATED [GOC:vw] is_a: GO:0032991 ! protein-containing complex created_by: tanyaberardini creation_date: 2012-08-23T14:20:39Z [Term] id: GO:0090444 name: regulation of nematode larval development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:17550772] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0061062 ! regulation of nematode larval development created_by: tanyaberardini creation_date: 2012-08-24T13:24:43Z [Term] id: GO:0090445 name: positive regulation of nematode larval development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [PMID:17550772] is_a: GO:0045962 ! positive regulation of development, heterochronic is_a: GO:0061063 ! positive regulation of nematode larval development is_a: GO:0090444 ! regulation of nematode larval development, heterochronic created_by: tanyaberardini creation_date: 2012-08-24T13:24:43Z [Term] id: GO:0090446 name: negative regulation of nematode larval development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [PMID:17550772] is_a: GO:0045961 ! negative regulation of development, heterochronic is_a: GO:0061064 ! negative regulation of nematode larval development is_a: GO:0090444 ! regulation of nematode larval development, heterochronic created_by: tanyaberardini creation_date: 2012-08-24T13:24:43Z [Term] id: GO:0090447 name: glycerol-3-phosphate 2-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.198] is_a: GO:0008374 ! O-acyltransferase activity created_by: tanyaberardini creation_date: 2012-08-31T09:23:12Z [Term] id: GO:0090448 name: glucosinolate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)." [PMID:22864417] synonym: "glucosinolate:hydrogen symporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity created_by: tanyaberardini creation_date: 2012-09-07T16:10:37Z [Term] id: GO:0090449 name: phloem glucosinolate loading namespace: biological_process def: "The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [PMID:22864417] is_a: GO:0110126 ! phloem loading is_a: GO:1901349 ! glucosinolate transport created_by: tanyaberardini creation_date: 2012-09-07T16:21:22Z [Term] id: GO:0090451 name: cotyledon boundary formation namespace: biological_process def: "The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained." [GOC:tb] is_a: GO:0090691 ! formation of plant organ boundary created_by: tanyaberardini creation_date: 2012-09-19T10:26:54Z [Term] id: GO:0090452 name: lithium ion transmembrane transport namespace: biological_process def: "The directed movement of lithium ions across a membrane." [GOC:tb] synonym: "lithium ion import" NARROW [] synonym: "lithium ion uptake" EXACT [GOC:tb] is_a: GO:0010351 ! lithium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:04:41Z [Term] id: GO:0090453 name: aspartate transmembrane import into vacuole namespace: biological_process def: "The directed movement of aspartate into the vacuole across the vacuolar membrane." [GOC:tb] synonym: "vacuolar aspartate import" EXACT [GOC:tb] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0034487 ! vacuolar amino acid transmembrane transport is_a: GO:0043090 ! amino acid import created_by: tanyaberardini creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090454 name: glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb] synonym: "vacuolar glutamate import" RELATED [GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole created_by: tanyaberardini creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090455 name: ornithine transmembrane import into vacuole namespace: biological_process def: "The directed movement of ornithine into the vacuole across the vacuolar membrane." [GOC:tb] synonym: "vacuolar ornithine import" RELATED [GOC:tb] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015822 ! ornithine transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0043090 ! amino acid import is_a: GO:0098655 ! cation transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090459 name: aspartate homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell." [GOC:tb] is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090460 name: threonine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of threonine within an organism or cell." [GOC:tb] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090461 name: glutamate homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell." [GOC:tb] is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090462 name: ornithine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell." [GOC:tb] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090463 name: lysine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of lysine within an organism or cell." [GOC:tb] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090464 name: histidine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of histidine within an organism or cell." [GOC:tb] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090465 name: arginine homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of arginine within an organism or cell." [GOC:tb] is_a: GO:0055080 ! cation homeostasis is_a: GO:0080144 ! amino acid homeostasis created_by: tanyaberardini creation_date: 2012-09-24T14:22:02Z [Term] id: GO:0090470 name: shoot organ boundary specification namespace: biological_process def: "The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained." [PMID:18757555] is_a: GO:0090691 ! formation of plant organ boundary created_by: tanyaberardini creation_date: 2012-09-24T16:22:03Z [Term] id: GO:0090471 name: 9,15,9'-tri-cis-zeta-carotene isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene." [EC:5.2.1.12] synonym: "9,15,9'-tricis-zeta-carotene cis-trans-isomerase" RELATED [] is_a: GO:0016859 ! cis-trans isomerase activity created_by: tanyaberardini creation_date: 2012-09-24T16:29:49Z [Term] id: GO:0090472 name: dibasic protein processing namespace: biological_process def: "Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein." [GOC:al] is_a: GO:0016485 ! protein processing created_by: tanyaberardini creation_date: 2012-10-01T10:39:26Z [Term] id: GO:0090473 name: lys-arg specific dibasic protein processing namespace: biological_process def: "Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein." [GOC:al] is_a: GO:0090472 ! dibasic protein processing created_by: tanyaberardini creation_date: 2012-10-01T10:42:30Z [Term] id: GO:0090474 name: arg-arg specific dibasic protein processing namespace: biological_process def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein." [GOC:al] is_a: GO:0090472 ! dibasic protein processing created_by: tanyaberardini creation_date: 2012-10-01T10:42:30Z [Term] id: GO:0090475 name: lys-lys specific dibasic protein processing namespace: biological_process def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein." [GOC:al] is_a: GO:0090472 ! dibasic protein processing created_by: tanyaberardini creation_date: 2012-10-01T10:42:30Z [Term] id: GO:0090480 name: purine nucleotide-sugar transmembrane transport namespace: biological_process alt_id: GO:0036079 def: "The process in which a purine nucleotide-sugar is transported across a membrane.\nPurine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "purine nucleotide-sugar membrane transport" EXACT [] synonym: "purine nucleotide-sugar transport" RELATED [] is_a: GO:0015780 ! nucleotide-sugar transmembrane transport created_by: tanyaberardini creation_date: 2011-12-19T03:22:58Z [Term] id: GO:0090481 name: pyrimidine nucleotide-sugar transmembrane transport namespace: biological_process alt_id: GO:0015781 def: "The process in which a pyrimidine nucleotide-sugar is transported across a membrane.\nPyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pyrimidine nucleotide-sugar membrane transport" EXACT [] synonym: "pyrimidine nucleotide-sugar transport" RELATED [] is_a: GO:0015780 ! nucleotide-sugar transmembrane transport created_by: tanyaberardini creation_date: 2012-10-01T16:43:54Z [Term] id: GO:0090482 name: vitamin transmembrane transporter activity namespace: molecular_function alt_id: GO:0051183 def: "Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb] synonym: "vitamin or cofactor transporter activity" BROAD [] synonym: "vitamin transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0035461 ! vitamin transmembrane transport created_by: tanyaberardini creation_date: 2012-10-02T16:50:50Z [Term] id: GO:0090483 name: phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine." [PMID:22988102] synonym: "cardiolipin synthase" RELATED [GOC:tb] is_a: GO:0030572 ! phosphatidyltransferase activity created_by: tanyaberardini creation_date: 2012-10-03T14:20:05Z [Term] id: GO:0090485 name: obsolete chromosome number maintenance namespace: biological_process def: "OBSOLETE. The maintenance of the standard number of chromosomes in a cell." [GOC:tb] comment: The reason for obsoletion is that this term represents a phenotype, and could be captured by other terms such as GO:0007059 chromosome segregation or GO:1903467 negative regulation of mitotic DNA replication initiation. synonym: "diploidization" RELATED [GOC:tb] synonym: "haploidization" RELATED [GOC:tb] is_obsolete: true consider: GO:0007059 consider: GO:1903467 created_by: tanyaberardini creation_date: 2012-10-05T11:21:45Z [Term] id: GO:0090486 name: small RNA 2'-O-methyltransferase namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide." [EC:2.1.1.n8, GOC:tb, GOC:vw] is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity created_by: tanyaberardini creation_date: 2012-10-15T16:32:49Z [Term] id: GO:0090487 name: secondary metabolite catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:tb] synonym: "secondary metabolite breakdown" EXACT [GOC:tb] synonym: "secondary metabolite catabolism" EXACT [GOC:tb] synonym: "secondary metabolite degradation" EXACT [GOC:tb] is_a: GO:0009056 ! catabolic process is_a: GO:0019748 ! secondary metabolic process created_by: tanyaberardini creation_date: 2012-10-15T16:43:09Z [Term] id: GO:0090488 name: polo box domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases." [GOC:al, GOC:tb, Pfam:PF00659, PMID:12352953] is_a: GO:0019904 ! protein domain specific binding created_by: tanyaberardini creation_date: 2012-10-16T10:47:30Z [Term] id: GO:0090489 name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) namespace: molecular_function def: "Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O." [EC:1.14.13.125, KEGG_REACTION:R08160] synonym: "tryptophan N-monooxygenase activity" RELATED [] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen relationship: has_part GO:0090490 ! L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) relationship: has_part GO:0090491 ! N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) relationship: has_part GO:0090492 ! N,N-Dihydroxy-L-tryptophan decarboxylase activity created_by: tanyaberardini creation_date: 2012-10-16T16:22:19Z [Term] id: GO:0090490 name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) namespace: molecular_function def: "Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09583] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: tanyaberardini creation_date: 2012-10-16T16:27:19Z [Term] id: GO:0090491 name: N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) namespace: molecular_function def: "Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09584] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: tanyaberardini creation_date: 2012-10-16T16:27:19Z [Term] id: GO:0090492 name: N,N-Dihydroxy-L-tryptophan decarboxylase activity namespace: molecular_function def: "Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O." [KEGG_REACTION:R09585] is_a: GO:0016831 ! carboxy-lyase activity created_by: tanyaberardini creation_date: 2012-10-16T16:32:30Z [Term] id: GO:0090493 name: catecholamine uptake namespace: biological_process def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0051937 ! catecholamine transport is_a: GO:0098657 ! import into cell created_by: tanyaberardini creation_date: 2012-10-17T11:06:17Z [Term] id: GO:0090494 name: dopamine uptake namespace: biological_process def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0015872 ! dopamine transport is_a: GO:0090493 ! catecholamine uptake created_by: tanyaberardini creation_date: 2012-10-17T11:12:09Z [Term] id: GO:0090495 name: low-density lipoprotein particle disassembly namespace: biological_process def: "The disaggregation of a low-density lipoprotein particle into its constituent components." [GOC:dph, GOC:tb] is_a: GO:0071829 ! plasma lipoprotein particle disassembly created_by: tanyaberardini creation_date: 2012-10-17T11:48:56Z [Term] id: GO:0090496 name: mesenchyme migration involved in limb bud formation namespace: biological_process def: "The migration of mesenchymal tissue that contributes to the formation of a limb bud." [GOC:dph, GOC:tb] is_a: GO:0090131 ! mesenchyme migration intersection_of: GO:0090131 ! mesenchyme migration intersection_of: part_of GO:0060174 ! limb bud formation relationship: part_of GO:0060174 ! limb bud formation created_by: tanyaberardini creation_date: 2012-10-17T12:04:20Z [Term] id: GO:0090497 name: mesenchymal cell migration namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal-type cell migration created_by: tanyaberardini creation_date: 2012-10-17T12:08:17Z [Term] id: GO:0090498 name: extrinsic component of Golgi membrane namespace: cellular_component def: "The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, PMID:21337012] synonym: "extrinsic to Golgi membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0000139 ! Golgi membrane relationship: part_of GO:0000139 ! Golgi membrane created_by: tanyaberardini creation_date: 2012-10-18T14:12:48Z [Term] id: GO:0090499 name: pimelyl-[acyl-carrier protein] methyl ester esterase activity namespace: molecular_function def: "Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol." [EC:3.1.1.85, PMID:23045647] comment: Note that while this reaction occurs on a modified protein (acyl-carrier protein), the ACP only acts as a carrier that later releases the end product. synonym: "pimelyl-[acyl-carrier protein] methyl ester hydrolase activity" RELATED [] is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: tanyaberardini creation_date: 2012-10-19T12:10:01Z [Term] id: GO:0090500 name: endocardial cushion to mesenchymal transition namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition created_by: tanyaberardini creation_date: 2012-10-22T11:51:44Z [Term] id: GO:0090501 name: RNA phosphodiester bond hydrolysis namespace: biological_process def: "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis created_by: tanyaberardini creation_date: 2012-10-22T12:05:27Z [Term] id: GO:0090502 name: RNA phosphodiester bond hydrolysis, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis created_by: tanyaberardini creation_date: 2012-10-22T12:05:27Z [Term] id: GO:0090503 name: RNA phosphodiester bond hydrolysis, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis created_by: tanyaberardini creation_date: 2012-10-22T12:05:27Z [Term] id: GO:0090504 name: epiboly namespace: biological_process def: "The expansion of one cell sheet over other cells or yolk." [GOC:dph, GOC:tb] is_a: GO:0002011 ! morphogenesis of an epithelial sheet created_by: tanyaberardini creation_date: 2012-10-22T12:29:52Z [Term] id: GO:0090505 name: epiboly involved in wound healing namespace: biological_process def: "The expansion of one cell sheet over other cells involved in wound healing." [GOC:dph, GOC:tb] is_a: GO:0090504 ! epiboly intersection_of: GO:0090504 ! epiboly intersection_of: part_of GO:0042060 ! wound healing relationship: part_of GO:0042060 ! wound healing created_by: tanyaberardini creation_date: 2012-10-22T12:38:51Z [Term] id: GO:0090506 name: axillary shoot meristem initiation namespace: biological_process def: "A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf." [GOC:tb] synonym: "axillary bud meristem initiation" RELATED [] is_a: GO:0010014 ! meristem initiation relationship: part_of GO:0010223 ! secondary shoot formation created_by: tanyaberardini creation_date: 2012-10-23T14:47:00Z [Term] id: GO:0090507 name: phenylethylamine metabolic process involved in synaptic transmission namespace: biological_process def: "The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission." [GOC:tb] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042443 ! phenylethylamine metabolic process intersection_of: GO:0042443 ! phenylethylamine metabolic process intersection_of: part_of GO:0007268 ! chemical synaptic transmission relationship: part_of GO:0007268 ! chemical synaptic transmission created_by: tanyaberardini creation_date: 2012-11-15T15:06:08Z [Term] id: GO:0090508 name: phenylethylamine biosynthetic process involved in synaptic transmission namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission." [GOC:tb] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042444 ! phenylethylamine biosynthetic process is_a: GO:0090507 ! phenylethylamine metabolic process involved in synaptic transmission intersection_of: GO:0042444 ! phenylethylamine biosynthetic process intersection_of: part_of GO:0007268 ! chemical synaptic transmission created_by: tanyaberardini creation_date: 2012-11-15T15:10:23Z [Term] id: GO:0090510 name: anticlinal cell division namespace: biological_process def: "A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file." [GOC:tair_curators, PMID:21391814] is_a: GO:0051301 ! cell division created_by: tanyaberardini creation_date: 2012-11-21T11:52:40Z [Term] id: GO:0090511 name: periclinal cell division namespace: biological_process def: "A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file." [GOC:tair_curators, PMID:21391814] is_a: GO:0051301 ! cell division created_by: tanyaberardini creation_date: 2012-11-21T11:52:40Z [Term] id: GO:0090512 name: eisosome membrane domain/MCC namespace: cellular_component def: "A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins." [GOC:al, GOC:vw, PMID:22368779] is_a: GO:0044853 ! plasma membrane raft relationship: part_of GO:0032126 ! eisosome created_by: tanyaberardini creation_date: 2012-12-07T17:00:19Z [Term] id: GO:0090513 name: L-histidine transmembrane import into vacuole namespace: biological_process alt_id: GO:0090457 def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al] synonym: "histidine transmembrane import into vacuole" BROAD [] synonym: "vacuolar histidine import" BROAD [GOC:tb] is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:1902024 ! L-histidine transport created_by: tanyaberardini creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090514 name: L-tyrosine transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015828 ! tyrosine transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: tanyaberardini creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090515 name: L-glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0051938 ! L-glutamate import is_a: GO:0090454 ! glutamate transmembrane import into vacuole created_by: tanyaberardini creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090516 name: L-serine transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-serine into the vacuole across the vacuolar membrane." [GOC:al] is_a: GO:0015825 ! L-serine transport is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: tanyaberardini creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090517 name: L-lysine transmembrane import into vacuole namespace: biological_process alt_id: GO:0090456 def: "The directed movement of L-lysine into the vacuole across the vacuolar membrane." [GOC:al] synonym: "lysine transmembrane import into vacuole" BROAD [] synonym: "vacuolar lysine import" BROAD [GOC:tb] is_a: GO:0015819 ! lysine transport is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole is_a: GO:1903401 ! L-lysine transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090518 name: L-arginine transmembrane import into vacuole namespace: biological_process alt_id: GO:0090458 def: "The directed movement of L-arginine into the vacuole across the vacuolar membrane." [GOC:al] synonym: "arginine transmembrane import into vacuole" BROAD [] synonym: "vacuolar arginine import" EXACT [GOC:tb] is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole is_a: GO:1903400 ! L-arginine transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090519 name: anoxia protection namespace: biological_process def: "Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia." [GOC:tb, PMID:19372430] is_a: GO:0034059 ! response to anoxia created_by: tanyaberardini creation_date: 2012-12-21T15:37:37Z [Term] id: GO:0090520 name: sphingolipid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid." [PMID:9525917] synonym: "ceramide 1-phosphate signaling pathway" NARROW [PMID:20870412] synonym: "ceramide signaling pathway" NARROW [PMID:20870412] synonym: "sphingolipid mediated signal transduction" EXACT [GOC:signaling] synonym: "sphingolipid signaling pathway" RELATED [] synonym: "sphingolipid-mediated signaling pathway" EXACT [GOC:signaling] synonym: "sphingosine signaling pathway" NARROW [PMID:20870412] is_a: GO:0007165 ! signal transduction created_by: tanyaberardini creation_date: 2013-01-08T09:30:54Z [Term] id: GO:0090521 name: glomerular visceral epithelial cell migration namespace: biological_process def: "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell." [GOC:pm, PMID:21402783] synonym: "podocyte cell migration" RELATED [GOC:pm] is_a: GO:0010631 ! epithelial cell migration created_by: tanyaberardini creation_date: 2013-01-08T11:08:57Z [Term] id: GO:0090522 name: vesicle tethering involved in exocytosis namespace: biological_process def: "The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008] synonym: "vesicle tethering to plasma membrane" NARROW [] is_a: GO:0099022 ! vesicle tethering is_a: GO:0140029 ! exocytic process intersection_of: GO:0099022 ! vesicle tethering intersection_of: part_of GO:0006887 ! exocytosis created_by: tanyaberardini creation_date: 2013-01-08T15:07:50Z [Term] id: GO:0090523 name: cytochrome-b5 reductase activity, acting on NADPH namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)." [GOC:tb] synonym: "cytochrome-b5 reductase activity" BROAD [] is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H created_by: tanyaberardini creation_date: 2013-01-11T12:21:41Z [Term] id: GO:0090524 name: cytochrome-b5 reductase activity, acting on NADH namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [GOC:tb] synonym: "cytochrome b5 reductase activity" BROAD [] is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H created_by: tanyaberardini creation_date: 2013-01-11T12:21:50Z [Term] id: GO:0090527 name: actin filament reorganization namespace: biological_process def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0031532 ! actin cytoskeleton reorganization created_by: tanyaberardini creation_date: 2013-01-23T10:27:44Z [Term] id: GO:0090528 name: smooth septate junction assembly namespace: biological_process def: "The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:22854041] is_a: GO:0019991 ! septate junction assembly created_by: tanyaberardini creation_date: 2013-02-05T14:47:40Z [Term] id: GO:0090529 name: cell septum assembly namespace: biological_process alt_id: GO:0090530 def: "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cell septum assembly involved in cell cycle cytokinesis" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process created_by: tanyaberardini creation_date: 2013-02-06T10:26:38Z [Term] id: GO:0090531 name: L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose." [GOC:yaf, PMID:11153268] synonym: "L-ascorbic acid biosynthesis via GDP-alpha-D-mannose" RELATED [] synonym: "Smirnoff-Wheeler's pathway" RELATED [] xref: BioCyc:PWY-882 is_a: GO:0019853 ! L-ascorbic acid biosynthetic process created_by: tanyaberardini creation_date: 2013-02-06T15:31:01Z [Term] id: GO:0090532 name: L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate." [BioCyc:PWY3DJ-35471, GOC:yaf, PMID:11153268, UniPathway:UPA00991] comment: This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans. synonym: "L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate" RELATED [] is_a: GO:0019853 ! L-ascorbic acid biosynthetic process created_by: tanyaberardini creation_date: 2013-02-06T15:31:01Z [Term] id: GO:0090533 name: cation-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:BHF] is_a: GO:0098533 ! ATPase dependent transmembrane transport complex created_by: tanyaberardini creation_date: 2013-02-07T15:50:28Z [Term] id: GO:0090534 name: calcium ion-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF] is_a: GO:0090533 ! cation-transporting ATPase complex created_by: tanyaberardini creation_date: 2013-02-07T15:52:58Z [Term] id: GO:0090535 name: WICH complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179] is_a: GO:0031010 ! ISWI-type complex created_by: tanyaberardini creation_date: 2013-02-11T14:07:14Z [Term] id: GO:0090536 name: NoRC complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc] is_a: GO:0031010 ! ISWI-type complex created_by: tanyaberardini creation_date: 2013-02-11T14:07:14Z [Term] id: GO:0090537 name: CERF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters." [GOC:krc] is_a: GO:0031010 ! ISWI-type complex created_by: tanyaberardini creation_date: 2013-02-11T14:07:14Z [Term] id: GO:0090538 name: peptide pheromone secretion namespace: biological_process def: "The regulated release of a peptide pheromone from a cell." [GOC:al, GOC:tb, GOC:vw] is_a: GO:0000770 ! peptide pheromone export is_a: GO:0030072 ! peptide hormone secretion created_by: tanyaberardini creation_date: 2013-02-11T15:38:29Z [Term] id: GO:0090539 name: peptide pheromone export by transmembrane transport namespace: biological_process def: "The directed movement of a peptide pheromone across a membrane and out of a cell." [GOC:al, GOC:tb, GOC:vw] synonym: "peptide pheromone export by membrane transport" EXACT [] is_a: GO:0000770 ! peptide pheromone export is_a: GO:0140115 ! export across plasma membrane created_by: tanyaberardini creation_date: 2013-02-11T15:44:51Z [Term] id: GO:0090540 name: bacterial cellulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria." [DOI:10.1016/S0268-005X(87)80024-3, DOI:10.1023/A\:1009272904582, GOC:tb, GOC:yaf, UniPathway:UPA00694] synonym: "bacterial cellulose biosynthesis" EXACT [GOC:yaf] is_a: GO:0030244 ! cellulose biosynthetic process created_by: tanyaberardini creation_date: 2013-02-11T16:32:44Z [Term] id: GO:0090541 name: MIT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking." [GOC:pm, InterPro:IPR007330] is_a: GO:0019904 ! protein domain specific binding created_by: tanyaberardini creation_date: 2013-02-14T17:11:29Z [Term] id: GO:0090542 name: ELYC domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ELYC domain of a protein. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC." [GOC:pm, PMID:18032582, PMID:19525971] is_a: GO:0019904 ! protein domain specific binding created_by: tanyaberardini creation_date: 2013-02-14T17:11:29Z [Term] id: GO:0090543 name: Flemming body namespace: cellular_component def: "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge." [GOC:pm, PMID:18641129, PMID:22522702] synonym: "Midbody ring" RELATED [PMID:18329369] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030496 ! midbody created_by: tanyaberardini creation_date: 2013-02-14T17:24:43Z [Term] id: GO:0090545 name: CHD-type complex namespace: cellular_component def: "A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure." [GOC:krc, GOC:tb, PMID:17350655] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: tanyaberardini creation_date: 2013-02-15T12:11:57Z [Term] id: GO:0090546 name: chlorophyll fluorescence namespace: biological_process def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light." [PMID:10938857] is_a: GO:1990066 ! energy quenching created_by: tanyaberardini creation_date: 2013-03-27T14:23:27Z [Term] id: GO:0090547 name: response to low humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere." [GOC:tb] is_a: GO:0009270 ! response to humidity created_by: tanyaberardini creation_date: 2013-04-17T13:46:28Z [Term] id: GO:0090548 name: response to nitrate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate." [GOC:tair_curators] is_a: GO:0042594 ! response to starvation created_by: tanyaberardini creation_date: 2013-04-22T13:57:16Z [Term] id: GO:0090549 name: response to carbon starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source." [GOC:tair_curators, PMID:18245858] is_a: GO:0042594 ! response to starvation created_by: tanyaberardini creation_date: 2013-04-22T13:57:16Z [Term] id: GO:0090550 name: response to molybdenum starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum." [GOC:tair_curators] is_a: GO:0042594 ! response to starvation created_by: tanyaberardini creation_date: 2013-04-22T13:57:16Z [Term] id: GO:0090551 name: response to manganese starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese." [GOC:tair_curators] is_a: GO:0042594 ! response to starvation created_by: tanyaberardini creation_date: 2013-04-22T13:57:16Z [Term] id: GO:0090552 name: unicellular trichome apex namespace: cellular_component def: "A cell projection part that is the apical most portion of a unicellular trichome." [GOC:PO_curators, PO:0025537] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0042995 ! cell projection created_by: tanyaberardini creation_date: 2013-04-25T11:56:56Z [Term] id: GO:0090553 name: unicellular trichome tip namespace: cellular_component def: "A cell projection part that is the apical most portion of a unicellular trichome apex." [GOC:PO_curators] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0090552 ! unicellular trichome apex created_by: tanyaberardini creation_date: 2013-04-25T11:56:56Z [Term] id: GO:0090554 name: phosphatidylcholine floppase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [CHEBI:64612, GOC:ab, PMID:16452632, RHEA:38584] synonym: "ATP-dependent phosphatidylcholine transporter activity" BROAD [] synonym: "ATPase-coupled phosphatidylcholine transporter activity" BROAD [] synonym: "phosphatidylcholine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "phosphatidylcholine-translocating ATPase activity" BROAD [] is_a: GO:0008525 ! phosphatidylcholine transporter activity is_a: GO:0140328 ! floppase activity created_by: tanyaberardini creation_date: 2013-10-24T16:07:20Z [Term] id: GO:0090555 name: phosphatidylethanolamine flippase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [CHEBI:64612, GOC:ab, PMID:16452632, RHEA:36440] comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED [] synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD [] synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] synonym: "phosphatidylethanolamine-translocating ATPase activity" RELATED [] is_a: GO:0140333 ! glycerophospholipid flippase activity created_by: tanyaberardini creation_date: 2013-10-24T16:07:20Z [Term] id: GO:0090556 name: phosphatidylserine floppase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [CHEBI:57262, GOC:ab, PMID:16452632, PMID:20224745, RHEA:38568] synonym: "ATPase-coupled phosphatidylserine transporter activity" BROAD [] synonym: "ATPase-dependent phosphatidylserine transporter activity" BROAD [] synonym: "phosphatidylserine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "phosphatidylserine-translocating ATPase activity" BROAD [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140328 ! floppase activity created_by: tanyaberardini creation_date: 2013-10-24T16:07:20Z [Term] id: GO:0090557 name: establishment of endothelial intestinal barrier namespace: biological_process def: "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:krc, PMID:22155109] is_a: GO:0061028 ! establishment of endothelial barrier created_by: tanyaberardini creation_date: 2013-10-29T15:08:27Z [Term] id: GO:0090558 name: plant epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0009888 ! tissue development created_by: tanyaberardini creation_date: 2014-02-27T15:17:37Z [Term] id: GO:0090559 name: regulation of membrane permeability namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] is_a: GO:0065008 ! regulation of biological quality created_by: tanyaberardini creation_date: 2014-03-27T13:48:35Z [Term] id: GO:0090560 name: 2-(3-amino-3-carboxypropyl)histidine synthase activity namespace: molecular_function def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [BRENDA:2.5.1.108, GOC:pde, PMID:15485916] xref: MetaCyc:RXN-11371 xref: Reactome:R-HSA-5358494 "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: tanyaberardini creation_date: 2014-03-27T14:58:50Z [Term] id: GO:0090561 name: nuclear migration during mitotic telophase namespace: biological_process def: "The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis." [GOC:vw, PMID:23087209] is_a: GO:0030473 ! nuclear migration along microtubule created_by: tanyaberardini creation_date: 2014-03-27T15:17:10Z [Term] id: GO:0090562 name: protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-04-08T14:55:02Z [Term] id: GO:0090563 name: protein-phosphocysteine-sugar phosphotransferase activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0022804 ! active transmembrane transporter activity created_by: tanyaberardini creation_date: 2014-04-08T14:58:00Z [Term] id: GO:0090564 name: protein-phosphocysteine-glucose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-04-08T15:03:08Z [Term] id: GO:0090565 name: protein-phosphocysteine-mannitol phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-04-08T15:03:08Z [Term] id: GO:0090566 name: protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-04-08T15:08:43Z [Term] id: GO:0090567 name: reproductive shoot system development namespace: biological_process def: "The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure." [GOC:pj] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048367 ! shoot system development is_a: GO:0048608 ! reproductive structure development created_by: tanyaberardini creation_date: 2014-04-25T15:42:03Z [Term] id: GO:0090568 name: nuclear transcriptional repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription." [GOC:tb] is_a: GO:0017053 ! transcriptional repressor complex intersection_of: GO:0017053 ! transcriptional repressor complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005654 ! nucleoplasm created_by: tanyaberardini creation_date: 2014-05-09T13:23:51Z [Term] id: GO:0090569 name: cytoplasmic transcriptional repressor complex namespace: cellular_component def: "A protein complex, located in the cytoplasm, that possesses activity that prevents or downregulates transcription." [GOC:tb] is_a: GO:0017053 ! transcriptional repressor complex intersection_of: GO:0017053 ! transcriptional repressor complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm created_by: tanyaberardini creation_date: 2014-05-09T13:23:51Z [Term] id: GO:0090570 name: RNA polymerase I transcription repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter." [GOC:tb] is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: tanyaberardini creation_date: 2014-05-09T13:26:16Z [Term] id: GO:0090571 name: RNA polymerase II transcription repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb] is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: tanyaberardini creation_date: 2014-05-09T13:26:16Z [Term] id: GO:0090572 name: RNA polymerase III transcription repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter." [GOC:tb] is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: tanyaberardini creation_date: 2014-05-09T13:26:16Z [Term] id: GO:0090573 name: RNA polymerase IV transcription repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter." [GOC:tb] is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: tanyaberardini creation_date: 2014-05-09T13:26:16Z [Term] id: GO:0090574 name: RNA polymerase V transcription repressor complex namespace: cellular_component def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter." [GOC:tb] is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: tanyaberardini creation_date: 2014-05-09T13:26:16Z [Term] id: GO:0090575 name: RNA polymerase II transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] is_a: GO:0044798 ! nuclear transcription factor complex created_by: tanyaberardini creation_date: 2014-05-09T14:04:37Z [Term] id: GO:0090576 name: RNA polymerase III transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III." [GOC:tb] is_a: GO:0044798 ! nuclear transcription factor complex created_by: tanyaberardini creation_date: 2014-05-09T14:04:37Z [Term] id: GO:0090577 name: RNA polymerase IV transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV." [GOC:tb] is_a: GO:0044798 ! nuclear transcription factor complex created_by: tanyaberardini creation_date: 2014-05-09T14:04:37Z [Term] id: GO:0090578 name: RNA polymerase V transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V." [GOC:tb] is_a: GO:0044798 ! nuclear transcription factor complex created_by: tanyaberardini creation_date: 2014-05-09T14:04:37Z [Term] id: GO:0090579 name: dsDNA loop formation namespace: biological_process def: "The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule." [GOC:jh, PMID:15950878] synonym: "chromatin looping" RELATED [GOC:dph] synonym: "dsDNA looping" EXACT [GOC:dph] is_a: GO:0051276 ! chromosome organization created_by: tanyaberardini creation_date: 2014-05-12T14:45:58Z [Term] id: GO:0090580 name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands namespace: molecular_function def: "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand." [GOC:pde, GOC:rb, PMID:11238902] is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140097 ! catalytic activity, acting on DNA created_by: tanyaberardini creation_date: 2014-05-14T15:52:41Z [Term] id: GO:0090581 name: protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)." [PMID:14645248] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090582 name: protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)." [PMID:8626640] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090583 name: protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)." [PMID:8875915] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090584 name: protein-phosphocysteine-galactitol-phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)." [PMID:8955298] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090585 name: protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)." [PMID:15153772] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090586 name: protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)." [PMID:8246840] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090587 name: protein-phosphocysteine-glucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)." [PMID:8246840] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090588 name: protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)." [PMID:15060041] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090589 name: protein-phosphocysteine-trehalose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)." [PMID:7608078] is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:22:31Z [Term] id: GO:0090590 name: protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)." [PMID:8246840] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:33:01Z [Term] id: GO:0090591 name: protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)." [PMID:9864311] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity created_by: tanyaberardini creation_date: 2014-06-04T16:33:01Z [Term] id: GO:0090592 name: DNA synthesis involved in DNA replication namespace: biological_process def: "Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA." [GOC:vw] is_a: GO:0071897 ! DNA biosynthetic process intersection_of: GO:0071897 ! DNA biosynthetic process intersection_of: part_of GO:0006260 ! DNA replication relationship: part_of GO:0006260 ! DNA replication created_by: tanyaberardini creation_date: 2014-06-06T13:54:36Z [Term] id: GO:0090593 name: peptidyl-histidine autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein." [PMID:15947782, PMID:8962061] is_a: GO:0046777 ! protein autophosphorylation created_by: tanyaberardini creation_date: 2014-06-06T14:19:46Z [Term] id: GO:0090594 name: inflammatory response to wounding namespace: biological_process def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add] is_a: GO:0006954 ! inflammatory response is_a: GO:0009611 ! response to wounding created_by: tanyaberardini creation_date: 2014-08-12T12:13:53Z [Term] id: GO:0090595 name: acetyl-CoA:L-lysine N6-acetyltransferase namespace: molecular_function def: "Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+)." [MetaCyc:LYSACET-RXN] is_a: GO:0008080 ! N-acetyltransferase activity created_by: tanyaberardini creation_date: 2014-08-21T17:19:06Z [Term] id: GO:0090596 name: sensory organ morphogenesis namespace: biological_process def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007423 ! sensory organ development created_by: tanyaberardini creation_date: 2014-08-22T13:23:20Z [Term] id: GO:0090597 name: nematode male tail mating organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules." [GOC:kmv, PMID:1782863, PMID:18050419, PMID:7409314] is_a: GO:0048808 ! male genitalia morphogenesis is_a: GO:0090596 ! sensory organ morphogenesis created_by: tanyaberardini creation_date: 2014-08-22T13:25:22Z [Term] id: GO:0090598 name: male anatomical structure morphogenesis namespace: biological_process def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0046661 ! male sex differentiation created_by: tanyaberardini creation_date: 2014-08-22T13:29:45Z [Term] id: GO:0090599 name: alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb] xref: EC:3.2.1.20 xref: Reactome:R-HSA-9036727 "GAA hydrolyzes lysosomal glycogen" xref: Reactome:R-HSA-9036729 "Defective GAA does not hydrolyze lysosomal glycogen" is_a: GO:0015926 ! glucosidase activity created_by: tanyaberardini creation_date: 2014-08-22T14:33:31Z [Term] id: GO:0090600 name: alpha-1,3-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose." [GOC:sd, GOC:tb] is_a: GO:0090599 ! alpha-glucosidase activity created_by: tanyaberardini creation_date: 2014-08-22T15:00:45Z [Term] id: GO:0090601 name: enucleation namespace: biological_process def: "The process in which nucleated precursor cells lose their nucleus." [GOC:tb] is_a: GO:0022411 ! cellular component disassembly created_by: tanyaberardini creation_date: 2014-09-05T16:25:16Z [Term] id: GO:0090602 name: sieve element enucleation namespace: biological_process def: "The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded." [GOC:tb, PMID:25081480] is_a: GO:0090601 ! enucleation relationship: part_of GO:0090603 ! sieve element differentiation created_by: tanyaberardini creation_date: 2014-09-05T16:25:16Z [Term] id: GO:0090603 name: sieve element differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve element." [GOC:tb] is_a: GO:0030154 ! cell differentiation created_by: tanyaberardini creation_date: 2014-09-05T16:38:20Z [Term] id: GO:0090604 name: surface biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] is_a: GO:0042710 ! biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:38:45Z [Term] id: GO:0090605 name: submerged biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] synonym: "solid substrate biofilm formation" RELATED [] is_a: GO:0042710 ! biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:44:46Z [Term] id: GO:0090606 name: single-species surface biofilm formation namespace: biological_process alt_id: GO:0032022 def: "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml] synonym: "multicellular pellicle formation" RELATED [] is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0090604 ! surface biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:47:11Z [Term] id: GO:0090607 name: multi-species surface biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of different species grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] is_a: GO:0044399 ! multi-species biofilm formation is_a: GO:0090604 ! surface biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:49:35Z [Term] id: GO:0090608 name: multi-species submerged biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of different species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] is_a: GO:0044399 ! multi-species biofilm formation is_a: GO:0090605 ! submerged biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:49:35Z [Term] id: GO:0090609 name: single-species submerged biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] is_a: GO:0044010 ! single-species biofilm formation is_a: GO:0090605 ! submerged biofilm formation created_by: tanyaberardini creation_date: 2014-09-16T14:55:15Z [Term] id: GO:0090610 name: bundle sheath cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:tb, PMID:24517883] is_a: GO:0001708 ! cell fate specification created_by: tanyaberardini creation_date: 2014-09-26T13:17:05Z [Term] id: GO:0090611 name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination." [PMID:22547407] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: has_part GO:0007039 ! protein catabolic process in the vacuole relationship: has_part GO:0071985 ! multivesicular body sorting pathway created_by: tanyaberardini creation_date: 2014-10-23T15:27:12Z [Term] id: GO:0090612 name: cAMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3." [PMID:24074367] synonym: "cyclic adenosine monophosphate deaminase activity" EXACT [] is_a: GO:0019239 ! deaminase activity created_by: tanyaberardini creation_date: 2014-10-23T15:46:42Z [Term] id: GO:0090613 name: 5'-deoxyadenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3." [PMID:23968233] is_a: GO:0019239 ! deaminase activity created_by: tanyaberardini creation_date: 2014-10-23T15:59:38Z [Term] id: GO:0090614 name: 5'-methylthioadenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3." [PMID:23968233] is_a: GO:0019239 ! deaminase activity created_by: tanyaberardini creation_date: 2014-10-23T15:59:38Z [Term] id: GO:0090615 name: mitochondrial mRNA processing namespace: biological_process def: "Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs." [GOC:tb, PMID:25181358] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0006397 ! mRNA processing intersection_of: GO:0006397 ! mRNA processing intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: tanyaberardini creation_date: 2014-10-24T12:43:27Z [Term] id: GO:0090616 name: mitochondrial mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358] is_a: GO:0000965 ! mitochondrial RNA 3'-end processing is_a: GO:0031124 ! mRNA 3'-end processing is_a: GO:0090615 ! mitochondrial mRNA processing intersection_of: GO:0031124 ! mRNA 3'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: tanyaberardini creation_date: 2014-10-24T12:45:08Z [Term] id: GO:0090617 name: mitochondrial mRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358] is_a: GO:0090615 ! mitochondrial mRNA processing created_by: tanyaberardini creation_date: 2014-10-24T12:45:08Z [Term] id: GO:0090618 name: DNA clamp unloading namespace: biological_process def: "The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates." [GOC:rb, PMID:23499004] synonym: "PCNA unloading" RELATED [GOC:rb, PMID:23499004] is_a: GO:0009987 ! cellular process created_by: tanyaberardini creation_date: 2014-10-29T12:57:05Z [Term] id: GO:0090619 name: meiotic spindle pole namespace: cellular_component def: "Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:ha, PMID:18250200] is_a: GO:0000922 ! spindle pole relationship: part_of GO:0072687 ! meiotic spindle created_by: tanyaberardini creation_date: 2014-12-16T16:38:34Z [Term] id: GO:0090620 name: obsolete APC-Cdc20 complex namespace: cellular_component def: "OBSOLETE. An anaphase promoting complex bound to the \"fizzy family\" APC activator Cdc20/Slp1 which regulates the metaphase anaphase transition by activating the APC/C to target the anaphase inhibitor securin and promotes sister chromatid separation." [GOC:vw, PMID:10921876] comment: This term was made obsolete because it is too fine-grained for GO. Consider Complex Portal EBI-1252490, Anaphase-Promoting Complex variant 2 as an alternate term. synonym: "APC-fizzy complex" EXACT [GOC:vw] synonym: "APC-Slp1 complex" EXACT [GOC:vw] synonym: "mitotic anaphase promotic complex" RELATED [GOC:vw] is_obsolete: true consider: GO:0005680 created_by: tanyaberardini creation_date: 2014-12-17T17:01:38Z [Term] id: GO:0090621 name: obsolete APC-fizzy-related complex namespace: cellular_component def: "OBSOLETE. An anaphase promoting complex bound to the \"fizzy-related family\" APC activator FZR1/Cdh1/Srw1 that regulates mitotic exit by activating the APC/C to target mitotic cyclins for destruction during anaphase and telophase. Is also active during G1." [GOC:vw, PMID:10921876] comment: This term was made obsolete because it is too fine-grained for GO. synonym: "APC-Hct1/Cdh1 complex" EXACT [GOC:vw] synonym: "APC-Srw1 complex" EXACT [GOC:vw] is_obsolete: true consider: GO:0005680 created_by: tanyaberardini creation_date: 2014-12-17T17:01:38Z [Term] id: GO:0090624 name: endoribonuclease activity, cleaving miRNA-paired mRNA namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters relationship: part_of GO:0035279 ! mRNA cleavage involved in gene silencing by miRNA created_by: tanyaberardini creation_date: 2015-01-21T16:28:52Z [Term] id: GO:0090625 name: mRNA cleavage involved in gene silencing by siRNA namespace: biological_process def: "The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970] is_a: GO:0098795 ! mRNA cleavage involved in gene silencing intersection_of: GO:0006379 ! mRNA cleavage intersection_of: part_of GO:0016246 ! RNA interference relationship: part_of GO:0016246 ! RNA interference created_by: tanyaberardini creation_date: 2015-01-21T17:15:13Z [Term] id: GO:0090626 name: plant epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the plant epidermis are generated and organized." [GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0090558 ! plant epidermis development created_by: tanyaberardini creation_date: 2015-01-29T14:54:03Z [Term] id: GO:0090627 name: plant epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell." [GOC:tb] is_a: GO:0030154 ! cell differentiation created_by: tanyaberardini creation_date: 2015-02-05T14:23:28Z [Term] id: GO:0090628 name: plant epidermal cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0090627 ! plant epidermal cell differentiation created_by: tanyaberardini creation_date: 2015-02-06T17:32:21Z [Term] id: GO:0090629 name: lagging strand initiation namespace: biological_process def: "The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started." [GOC:mah, GOC:tb] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006273 ! lagging strand elongation created_by: tanyaberardini creation_date: 2015-02-11T14:37:13Z [Term] id: GO:0090630 name: activation of GTPase activity namespace: biological_process alt_id: GO:0032856 alt_id: GO:0032857 alt_id: GO:0032858 alt_id: GO:0032859 alt_id: GO:0032860 alt_id: GO:0032861 alt_id: GO:0032862 alt_id: GO:0032863 alt_id: GO:0032864 def: "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of ARF GTPase activity" NARROW [] synonym: "activation of Cdc42 GTPase activity" NARROW [] synonym: "activation of Rab GTPase activity" NARROW [] synonym: "activation of Rac GTPase activity" NARROW [] synonym: "activation of Ral GTPase activity" NARROW [] synonym: "activation of Ran GTPase activity" NARROW [] synonym: "activation of Rap GTPase activity" NARROW [] synonym: "activation of Ras GTPase activity" NARROW [] synonym: "activation of Rho GTPase activity" NARROW [] synonym: "ARF GTPase activation" NARROW [] synonym: "Cdc42 GTPase activation" NARROW [] synonym: "Rab GTPase activation" NARROW [] synonym: "Rac GTPase activation" NARROW [] synonym: "Ral GTPase activation" NARROW [] synonym: "Ran GTPase activation" NARROW [] synonym: "Rap GTPase activation" NARROW [] synonym: "Ras GTPase activation" NARROW [] synonym: "Rho GTPase activation" NARROW [] is_a: GO:0043547 ! positive regulation of GTPase activity created_by: tanyaberardini creation_date: 2015-02-11T16:09:19Z [Term] id: GO:0090632 name: N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411] synonym: "CMP-Neu5Gc synthetase activity" EXACT [] is_a: GO:0070567 ! cytidylyltransferase activity created_by: tanyaberardini creation_date: 2015-03-19T15:05:54Z [Term] id: GO:0090633 name: keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411] synonym: "CMP-KDN synthetase activity" EXACT [] synonym: "cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity" EXACT [] is_a: GO:0070567 ! cytidylyltransferase activity created_by: tanyaberardini creation_date: 2015-03-19T15:05:54Z [Term] id: GO:0090634 name: microglial cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a microglial cell." [GOC:BHF, GOC:nc, PMID:19100238] is_a: GO:0001909 ! leukocyte mediated cytotoxicity created_by: tanyaberardini creation_date: 2015-04-14T14:04:54Z [Term] id: GO:0090635 name: extracellular core region of desmosome namespace: cellular_component def: "The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner." [PMID:20066089] synonym: "desmoglea" EXACT [PMID:20066089] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030057 ! desmosome created_by: tanyaberardini creation_date: 2015-04-20T16:10:51Z [Term] id: GO:0090636 name: outer dense plaque of desmosome namespace: cellular_component def: "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030057 ! desmosome created_by: tanyaberardini creation_date: 2015-04-20T16:10:51Z [Term] id: GO:0090637 name: inner dense plaque of desmosome namespace: cellular_component def: "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030057 ! desmosome created_by: tanyaberardini creation_date: 2015-04-20T16:10:51Z [Term] id: GO:0090638 name: phosphatidylcholine biosynthesis from phosphatidylethanolamine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations." [MetaCyc:PWY-6825] is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2015-04-23T15:56:12Z [Term] id: GO:0090639 name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol namespace: biological_process def: "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine." [MetaCyc:PWY-6826] is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2015-04-23T15:56:12Z [Term] id: GO:0090640 name: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine namespace: biological_process def: "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine." [MetaCyc:PWY-7470, PMID:24329598, PMID:27758859] is_a: GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2015-04-23T15:56:12Z [Term] id: GO:0090641 name: microsporidian-type endospore namespace: cellular_component def: "The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins." [PMID:19457051] comment: Microsporidian biology uses the term endospore differently than GO:0043593 endospore coat which is for a spore formed inside of another cell. Microsporidian endospore refers to the inner layer of the spore wall itself. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031160 ! spore wall created_by: tanyaberardini creation_date: 2015-05-04T14:17:06Z [Term] id: GO:0090642 name: microsporidian-type exospore namespace: cellular_component def: "The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore." [PMID:19457051, PMID:25363531] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031160 ! spore wall created_by: tanyaberardini creation_date: 2015-05-04T14:17:06Z [Term] id: GO:0090643 name: inflorescence phyllotactic patterning namespace: biological_process def: "The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem." [PMID:25352850] is_a: GO:0060771 ! phyllotactic patterning created_by: tanyaberardini creation_date: 2015-05-05T14:25:09Z [Term] id: GO:0090644 name: age-related resistance namespace: biological_process def: "An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR)." [PMID:17635216, PMID:19694953] synonym: "adult seedling resistance" NARROW [] synonym: "ARR" EXACT [] synonym: "developmental resistance" BROAD [] synonym: "flowering-induced resistance" NARROW [] synonym: "mature seedling resistance" NARROW [] synonym: "ontogenic resistance" BROAD [] synonym: "senescence-induced resistance" NARROW [] is_a: GO:0032502 ! developmental process is_a: GO:0045087 ! innate immune response created_by: tanyaberardini creation_date: 2015-05-19T10:36:38Z [Term] id: GO:0090646 name: mitochondrial tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0008033 ! tRNA processing created_by: tanyaberardini creation_date: 2015-06-12T15:57:13Z [Term] id: GO:0090647 name: modulation of age-related behavioral decline namespace: biological_process def: "Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:cjm, GOC:kmv, PMID:20523893] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007568 ! aging created_by: tanyaberardini creation_date: 2015-06-15T12:45:44Z [Term] id: GO:0090648 name: response to environmental enrichment namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment." [GOC:sl, PMID:23644055, PMID:25934034] synonym: "response to the introduction of novel objects" NARROW [] is_a: GO:0009605 ! response to external stimulus created_by: tanyaberardini creation_date: 2015-07-01T10:20:37Z [Term] id: GO:0090649 name: response to oxygen-glucose deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936] synonym: "response to OGD" EXACT [GOC:sl] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0036293 ! response to decreased oxygen levels created_by: tanyaberardini creation_date: 2015-07-01T10:27:29Z [Term] id: GO:0090650 name: cellular response to oxygen-glucose deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936] synonym: "cellular response to OGD" EXACT [GOC:sl] is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0036294 ! cellular response to decreased oxygen levels is_a: GO:0090649 ! response to oxygen-glucose deprivation created_by: tanyaberardini creation_date: 2015-07-01T10:27:29Z [Term] id: GO:0090651 name: apical cytoplasm namespace: cellular_component def: "The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0045177 ! apical part of cell created_by: tanyaberardini creation_date: 2015-07-01T15:46:19Z [Term] id: GO:0090652 name: basolateral cytoplasm namespace: cellular_component def: "The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: tanyaberardini creation_date: 2015-07-01T15:46:19Z [Term] id: GO:0090653 name: apical recycling endosome namespace: cellular_component def: "Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells." [PMID:12669082, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315] is_a: GO:0055037 ! recycling endosome relationship: part_of GO:0090651 ! apical cytoplasm created_by: tanyaberardini creation_date: 2015-07-01T15:46:19Z [Term] id: GO:0090654 name: basolateral recycling endosome namespace: cellular_component def: "Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells." [PMID:11389442, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315] is_a: GO:0055037 ! recycling endosome relationship: part_of GO:0090652 ! basolateral cytoplasm created_by: tanyaberardini creation_date: 2015-07-01T15:46:19Z [Term] id: GO:0090655 name: double-stranded/single-stranded junction telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang." [GOC:BHF, GOC:BHF_telomere, GOC:bhm, GOC:nc, PMID:21852327] is_a: GO:0000406 ! double-strand/single-strand DNA junction binding is_a: GO:0042162 ! telomeric DNA binding created_by: tanyaberardini creation_date: 2015-07-02T11:33:39Z [Term] id: GO:0090656 name: t-circle formation namespace: biological_process def: "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100] synonym: "telomeric circle formation" EXACT [] is_a: GO:0001325 ! formation of extrachromosomal circular DNA relationship: part_of GO:0090737 ! telomere maintenance via telomere trimming created_by: tanyaberardini creation_date: 2015-07-02T11:44:23Z [Term] id: GO:0090657 name: telomeric loop disassembly namespace: biological_process def: "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284] synonym: "T loop disassembly" EXACT [] synonym: "t-loop disassembly" EXACT [] is_a: GO:0000723 ! telomere maintenance created_by: tanyaberardini creation_date: 2015-07-07T13:53:40Z [Term] id: GO:0090658 name: cone matrix sheath namespace: cellular_component def: "A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments." [GOC:mr, PMID:2055688] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0033165 ! interphotoreceptor matrix created_by: tanyaberardini creation_date: 2015-07-15T13:35:32Z [Term] id: GO:0090659 name: walking behavior namespace: biological_process def: "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:tb] synonym: "locomotor gait pattern" NARROW [] is_a: GO:0007626 ! locomotory behavior created_by: tanyaberardini creation_date: 2015-08-27T16:34:28Z [Term] id: GO:0090660 name: cerebrospinal fluid circulation namespace: biological_process def: "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional." [GOC:mgi_curators, PMID:22100360, PMID:24229449] synonym: "cerebrospinal fluid flow" EXACT [] synonym: "CSF circulation" EXACT [] synonym: "CSF flow" EXACT [] is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement is_a: GO:0050877 ! nervous system process created_by: tanyaberardini creation_date: 2015-09-11T15:49:59Z [Term] id: GO:0090661 name: box H/ACA telomerase RNP complex namespace: cellular_component def: "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283] is_a: GO:0072588 ! box H/ACA RNP complex relationship: part_of GO:0005697 ! telomerase holoenzyme complex created_by: tanyaberardini creation_date: 2015-09-21T14:46:16Z [Term] id: GO:0090663 name: galanin-activated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor." [GOC:lb, PMID:25691535] synonym: "galanin signaling pathway" RELATED [] synonym: "galanin signalling pathway" RELATED [] synonym: "galanin-activated signalling pathway" EXACT [] is_a: GO:0007218 ! neuropeptide signaling pathway created_by: tanyaberardini creation_date: 2015-10-21T13:38:04Z [Term] id: GO:0090664 name: response to high population density namespace: biological_process def: "Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area." [GOC:mr, PMID:26439857] synonym: "response to crowding" EXACT [GOC:mr] is_a: GO:0006950 ! response to stress is_a: GO:0032501 ! multicellular organismal process created_by: tanyaberardini creation_date: 2015-10-21T16:00:30Z [Term] id: GO:0090665 name: glycoprotein complex namespace: cellular_component def: "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds." [GOC:pf, PMID:7693675, PMID:8662961] comment: An example is the Dictyostelium multi protein pspB complex, which is secreted from prespore vesicles and incorporated into the spore coat. is_a: GO:0032991 ! protein-containing complex created_by: tanyaberardini creation_date: 2015-12-11T17:45:23Z [Term] id: GO:0090666 name: scaRNA localization to Cajal body namespace: biological_process def: "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] is_a: GO:0090670 ! RNA localization to Cajal body created_by: tanyaberardini creation_date: 2015-12-15T10:57:05Z [Term] id: GO:0090667 name: cell chemotaxis to vascular endothelial growth factor namespace: biological_process def: "The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851] is_a: GO:0060326 ! cell chemotaxis relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus created_by: tanyaberardini creation_date: 2015-12-15T11:27:12Z [Term] id: GO:0090668 name: endothelial cell chemotaxis to vascular endothelial growth factor namespace: biological_process def: "The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851] is_a: GO:0090667 ! cell chemotaxis to vascular endothelial growth factor created_by: tanyaberardini creation_date: 2015-12-15T11:31:43Z [Term] id: GO:0090669 name: telomerase RNA stabilization namespace: biological_process def: "Prevention of degradation of telomerase RNA (TERC) molecules." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] synonym: "TERC stabilization" EXACT [] is_a: GO:0043489 ! RNA stabilization created_by: tanyaberardini creation_date: 2015-12-17T14:01:11Z [Term] id: GO:0090670 name: RNA localization to Cajal body namespace: biological_process def: "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] is_a: GO:0090685 ! RNA localization to nucleus created_by: tanyaberardini creation_date: 2015-12-17T14:04:40Z [Term] id: GO:0090671 name: telomerase RNA localization to Cajal body namespace: biological_process def: "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] is_a: GO:0090670 ! RNA localization to Cajal body is_a: GO:0090672 ! telomerase RNA localization created_by: tanyaberardini creation_date: 2015-12-17T14:06:21Z [Term] id: GO:0090672 name: telomerase RNA localization namespace: biological_process def: "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] is_a: GO:0006403 ! RNA localization created_by: tanyaberardini creation_date: 2015-12-17T14:08:01Z [Term] id: GO:0090673 name: endothelial cell-matrix adhesion namespace: biological_process def: "The binding of an endothelial cell to the extracellular matrix via adhesion molecules." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962] is_a: GO:0007160 ! cell-matrix adhesion created_by: tanyaberardini creation_date: 2016-01-15T15:38:11Z [Term] id: GO:0090674 name: endothelial cell-matrix adhesion via fibronectin namespace: biological_process def: "The binding of an endothelial cell to the extracellular matrix via fibronectin." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962] is_a: GO:0090673 ! endothelial cell-matrix adhesion created_by: tanyaberardini creation_date: 2016-01-15T15:40:58Z [Term] id: GO:0090675 name: intermicrovillar adhesion namespace: biological_process def: "The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin." [GOC:lb, PMID:24725409] is_a: GO:0022610 ! biological adhesion relationship: part_of GO:1904970 ! brush border assembly created_by: tanyaberardini creation_date: 2016-02-19T13:34:07Z [Term] id: GO:0090676 name: calcium ion transmembrane transport via low voltage-gated calcium channel namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel." [GOC:bf, GOC:PARL, PMID:20371816] synonym: "generation of T-type calcium current" RELATED [] is_a: GO:0070588 ! calcium ion transmembrane transport relationship: has_part GO:0008332 ! low voltage-gated calcium channel activity created_by: tanyaberardini creation_date: 2016-03-23T10:15:23Z [Term] id: GO:0090677 name: reversible differentiation namespace: biological_process def: "A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another." [GOC:curators] is_a: GO:0036166 ! phenotypic switching created_by: tanyaberardini creation_date: 2016-04-28T17:32:40Z [Term] id: GO:0090678 name: cell dedifferentiation involved in phenotypic switching namespace: biological_process def: "A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators] is_a: GO:0043697 ! cell dedifferentiation relationship: part_of GO:0090677 ! reversible differentiation created_by: tanyaberardini creation_date: 2016-04-28T17:32:40Z [Term] id: GO:0090679 name: cell differentiation involved in phenotypic switching namespace: biological_process def: "A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: part_of GO:0090677 ! reversible differentiation relationship: part_of GO:0090677 ! reversible differentiation created_by: tanyaberardini creation_date: 2016-04-28T17:32:40Z [Term] id: GO:0090680 name: disruption by virus of host outer membrane namespace: biological_process def: "A process by which a virus has a negative effect on the functioning of a host outer membrane." [PMID:17900620] is_a: GO:0044662 ! disruption by virus of host cell membrane created_by: tanyaberardini creation_date: 2016-05-04T15:52:02Z [Term] id: GO:0090681 name: GPCR taste receptor activity namespace: molecular_function def: "A G protein-coupled receptor activity that is responsible for the sense of taste." [GOC:hat, GOC:tb] synonym: "G-protein coupled taste receptor activity" EXACT [] synonym: "G-protein-coupled taste receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0008527 ! taste receptor activity created_by: tanyaberardini creation_date: 2016-05-20T15:47:18Z [Term] id: GO:0090682 name: GPCR bitter taste receptor activity namespace: molecular_function def: "A G protein-coupled receptor activity that is responsible for the sense of bitter taste." [GOC:hat, GOC:tb] synonym: "G protein-coupled receptor bitter taste receptor activity" EXACT [] synonym: "G-protein coupled receptor bitter taste receptor activity" EXACT [] is_a: GO:0033038 ! bitter taste receptor activity is_a: GO:0090681 ! GPCR taste receptor activity created_by: tanyaberardini creation_date: 2016-05-20T15:49:18Z [Term] id: GO:0090683 name: GPCR sweet taste receptor activity namespace: molecular_function def: "A G protein-coupled receptor activity that is responsible for the sense of sweet taste." [GOC:hat, GOC:tb] synonym: "G-protein coupled receptor sweet taste receptor activity" EXACT [] is_a: GO:0033041 ! sweet taste receptor activity is_a: GO:0090681 ! GPCR taste receptor activity created_by: tanyaberardini creation_date: 2016-05-20T15:49:18Z [Term] id: GO:0090684 name: contact chemoreceptor activity namespace: molecular_function def: "A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception." [GOC:hat, GOC:tb] synonym: "contact chemosensation receptor activity" EXACT [] is_a: GO:0008527 ! taste receptor activity created_by: tanyaberardini creation_date: 2016-05-20T15:53:01Z [Term] id: GO:0090685 name: RNA localization to nucleus namespace: biological_process def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] synonym: "RNA localisation to nucleus" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization created_by: tanyaberardini creation_date: 2016-07-19T17:00:49Z [Term] id: GO:0090686 name: glycine betaine-activated nonselective monovalent cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a monovalent cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts." [GOC:kmv, PMID:24212673] is_a: GO:0099094 ! ligand-gated cation channel activity created_by: tanyaberardini creation_date: 2016-07-20T16:29:01Z [Term] id: GO:0090687 name: activation of meiosis I spindle assembly checkpoint namespace: biological_process def: "Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint." [GOC:mah] is_a: GO:1905326 ! positive regulation of meiosis I spindle assembly checkpoint created_by: tanyaberardini creation_date: 2016-07-20T16:49:17Z [Term] id: GO:0090688 name: cleavage furrow rim namespace: cellular_component def: "The part of the cleavage furrow closest to the cell surface." [GOC:vw, PMID:27082518] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032154 ! cleavage furrow created_by: tanyaberardini creation_date: 2016-07-26T16:00:10Z [Term] id: GO:0090689 name: cleavage furrow leading edge namespace: cellular_component def: "The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring." [GOC:vw, PMID:27082518] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032154 ! cleavage furrow created_by: tanyaberardini creation_date: 2016-07-26T16:00:10Z [Term] id: GO:0090690 name: obsolete heteroreceptor complex namespace: cellular_component def: "OBSOLETE. A receptor complex that consists of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger. The formation of the higher level complex initiates a change in cell function." [GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794] comment: This term was obsoleted as it was created in error. is_obsolete: true created_by: tanyaberardini creation_date: 2016-08-24T09:47:15Z [Term] id: GO:0090691 name: formation of plant organ boundary namespace: biological_process def: "The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:tb] is_a: GO:0048859 ! formation of anatomical boundary created_by: tanyaberardini creation_date: 2016-08-24T10:16:28Z [Term] id: GO:0090692 name: mitochondrial membrane scission site namespace: cellular_component def: "The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission." [GOC:bc, GOC:PARL, PMID:26618722] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031966 ! mitochondrial membrane created_by: tanyaberardini creation_date: 2016-08-24T10:46:09Z [Term] id: GO:0090693 name: plant organ senescence namespace: biological_process def: "The process that occurs in a plant organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb] is_a: GO:0007568 ! aging relationship: part_of GO:0099402 ! plant organ development created_by: tanyaberardini creation_date: 2016-08-24T10:50:29Z [Term] id: GO:0090694 name: Scc2-Scc4 cohesin loading complex namespace: cellular_component def: "A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA." [GOC:vw, PMID:24291789] synonym: "Mis4-Ssl3 cohesin loading complex" EXACT [GOC:vw] is_a: GO:0032116 ! SMC loading complex created_by: tanyaberardini creation_date: 2016-08-24T17:09:11Z [Term] id: GO:0090695 name: Wpl/Pds5 cohesin loading/unloading complex namespace: cellular_component def: "A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA." [GOC:vw, PMID:26687354] is_a: GO:0032116 ! SMC loading complex created_by: tanyaberardini creation_date: 2016-08-24T17:09:11Z [Term] id: GO:0090696 name: post-embryonic plant organ development namespace: biological_process def: "Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb] is_a: GO:0009791 ! post-embryonic development is_a: GO:0099402 ! plant organ development created_by: tanyaberardini creation_date: 2016-08-25T16:35:55Z [Term] id: GO:0090697 name: post-embryonic plant organ morphogenesis namespace: biological_process def: "Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb] is_a: GO:0090698 ! post-embryonic plant morphogenesis is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0090696 ! post-embryonic plant organ development created_by: tanyaberardini creation_date: 2016-08-25T17:04:35Z [Term] id: GO:0090698 name: post-embryonic plant morphogenesis namespace: biological_process def: "The process, occurring after plant embryonic development, by which anatomical structures are generated and organized." [GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: tanyaberardini creation_date: 2016-08-25T17:08:33Z [Term] id: GO:0090699 name: repair of merotelic kinetochore attachment defect, meiosis I namespace: biological_process def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with meiotic spindle microtubules emanating from both spindle poles at meiosis I." [GOC:vw, PMID:21920317] synonym: "correction of merotelic kinetochore attachment, meiosis I" EXACT [] is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0043060 ! meiotic metaphase I plate congression created_by: tanyaberardini creation_date: 2016-08-29T14:03:26Z [Term] id: GO:0090700 name: maintenance of plant organ identity namespace: biological_process def: "The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb, PMID:9090883] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0099402 ! plant organ development created_by: tanyaberardini creation_date: 2016-08-29T15:01:08Z [Term] id: GO:0090701 name: specification of plant organ identity namespace: biological_process def: "The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization relationship: part_of GO:1905393 ! plant organ formation created_by: tanyaberardini creation_date: 2016-08-29T15:09:18Z [Term] id: GO:0090702 name: non-reproductive fruiting body development namespace: biological_process def: "The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies." [GOC:pf] is_a: GO:0099120 ! socially cooperative development created_by: tanyaberardini creation_date: 2016-09-09T16:14:21Z [Term] id: GO:0090703 name: obsolete triplex DNA unwinding namespace: biological_process def: "OBSOLETE. The process by which a three-stranded D-loop DNA is unwound or 'melted'." [PMID:26503245] comment: This term was made obsolete because it was created in error. is_obsolete: true created_by: tanyaberardini creation_date: 2016-09-20T16:37:15Z [Term] id: GO:0090704 name: nicotinate-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP." [GOC:tb, PMID:26116607] is_a: GO:0035251 ! UDP-glucosyltransferase activity created_by: tanyaberardini creation_date: 2016-09-21T12:46:21Z [Term] id: GO:0090705 name: trichome papilla namespace: cellular_component def: "A plant cell papilla that is part of a trichome cell." [GOC:tb, PMID:24014871] comment: Part of trichome cell (PO:0008030). is_a: GO:0090395 ! plant cell papilla created_by: tanyaberardini creation_date: 2016-09-26T12:49:36Z [Term] id: GO:0090706 name: specification of plant organ position namespace: biological_process def: "The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ." [GOC:tb, PMID:9611175] is_a: GO:0003002 ! regionalization relationship: part_of GO:1905392 ! plant organ morphogenesis created_by: tanyaberardini creation_date: 2016-10-05T12:33:21Z [Term] id: GO:0090707 name: establishment of plant organ orientation namespace: biological_process def: "The process that determines the orientation of a plant organ or tissue with reference to an axis." [GOC:tb] is_a: GO:0048560 ! establishment of anatomical structure orientation relationship: part_of GO:1905392 ! plant organ morphogenesis created_by: tanyaberardini creation_date: 2016-10-05T12:42:47Z [Term] id: GO:0090708 name: specification of plant organ axis polarity namespace: biological_process def: "The process in which the polarity of a plant organ axis is specified." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:1905392 ! plant organ morphogenesis created_by: tanyaberardini creation_date: 2016-10-05T12:47:11Z [Term] id: GO:0090709 name: regulation of timing of plant organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development." [GOC:tb] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:1905428 ! regulation of plant organ formation created_by: tanyaberardini creation_date: 2016-10-05T12:49:58Z [Term] id: GO:0090710 name: phosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate." [EC:4.1.1.99, MetaCyc:RXN-10067, PMID:24375100] is_a: GO:0016831 ! carboxy-lyase activity created_by: tanyaberardini creation_date: 2016-10-21T15:59:34Z [Term] id: GO:0090711 name: FMN hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: FMN + H2O = riboflavin + phosphate." [EC:3.1.3.102, PMID:16183635] is_a: GO:0016791 ! phosphatase activity created_by: tanyaberardini creation_date: 2016-10-21T16:27:34Z [Term] id: GO:0090712 name: basal pole of outer hair cell namespace: cellular_component def: "The end of the outer hair cell which receives and transmits neural signals." [GOC:sl, PMID:12845523] is_a: GO:0060187 ! cell pole created_by: tanyaberardini creation_date: 2016-11-01T12:57:03Z [Term] id: GO:0090713 name: immunological memory process namespace: biological_process def: "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] is_a: GO:0002376 ! immune system process relationship: part_of GO:0006955 ! immune response created_by: tanyaberardini creation_date: 2016-11-11T12:20:30Z [Term] id: GO:0090714 name: innate immunity memory response namespace: biological_process def: "An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus." [GOC:add, PMID:26086132] is_a: GO:0045087 ! innate immune response is_a: GO:0090713 ! immunological memory process created_by: tanyaberardini creation_date: 2016-11-11T12:23:03Z [Term] id: GO:0090715 name: immunological memory formation process namespace: biological_process def: "Any immunological memory process that can contribute to the formation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] is_a: GO:0090713 ! immunological memory process created_by: tanyaberardini creation_date: 2016-11-11T12:25:47Z [Term] id: GO:0090716 name: adaptive immune memory response namespace: biological_process def: "An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526] is_a: GO:0002250 ! adaptive immune response is_a: GO:0090713 ! immunological memory process created_by: tanyaberardini creation_date: 2016-11-11T12:32:42Z [Term] id: GO:0090717 name: adaptive immune memory response involving T cells and B cells namespace: biological_process def: "An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0090716 ! adaptive immune memory response created_by: tanyaberardini creation_date: 2016-11-11T12:35:19Z [Term] id: GO:0090718 name: adaptive immune effector response namespace: biological_process def: "An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response." [GOC:add, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response relationship: has_part GO:0002252 ! immune effector process created_by: tanyaberardini creation_date: 2016-11-11T12:37:26Z [Term] id: GO:0090719 name: adaptive immune effector response involving T cells and B lineage cells namespace: biological_process def: "An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells." [GOC:add, ISBN:1405196831] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0090718 ! adaptive immune effector response created_by: tanyaberardini creation_date: 2016-11-11T12:43:26Z [Term] id: GO:0090720 name: primary adaptive immune response namespace: biological_process def: "An adaptive immune response against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526] is_a: GO:0002250 ! adaptive immune response created_by: tanyaberardini creation_date: 2016-11-11T12:44:55Z [Term] id: GO:0090721 name: primary adaptive immune response involving T cells and B cells namespace: biological_process def: "An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0090720 ! primary adaptive immune response created_by: tanyaberardini creation_date: 2016-11-11T12:46:29Z [Term] id: GO:0090722 name: receptor-receptor interaction namespace: molecular_function def: "The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function." [GOC:dox, GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794] synonym: "hetero-receptor complex formation" EXACT [] is_a: GO:0005102 ! signaling receptor binding created_by: tanyaberardini creation_date: 2016-11-11T17:41:56Z [Term] id: GO:0090723 name: obsolete growth cone part namespace: cellular_component def: "OBSOLETE. Any constituent part of a growth cone, the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, GOC:tb] is_obsolete: true consider: GO:0030426 created_by: tanyaberardini creation_date: 2016-11-18T09:36:19Z [Term] id: GO:0090724 name: central region of growth cone namespace: cellular_component def: "The center of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030426 ! growth cone created_by: tanyaberardini creation_date: 2016-11-18T12:44:25Z [Term] id: GO:0090725 name: peripheral region of growth cone namespace: cellular_component def: "The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030426 ! growth cone created_by: tanyaberardini creation_date: 2016-11-18T12:44:25Z [Term] id: GO:0090726 name: cortical dynamic polarity patch namespace: cellular_component def: "A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation." [GOC:mah, PMID:23200991] synonym: "dynamic polarity patch at the cell cortex" EXACT [GOC:mah] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005938 ! cell cortex created_by: tanyaberardini creation_date: 2016-11-22T16:17:02Z [Term] id: GO:0090727 name: positive regulation of brood size namespace: biological_process def: "Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] is_a: GO:0060378 ! regulation of brood size created_by: tanyaberardini creation_date: 2016-12-19T15:07:32Z [Term] id: GO:0090728 name: negative regulation of brood size namespace: biological_process def: "Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] is_a: GO:0060378 ! regulation of brood size created_by: tanyaberardini creation_date: 2016-12-19T15:07:32Z [Term] id: GO:0090729 name: toxin activity namespace: molecular_function alt_id: GO:0050827 def: "Interacting selectively with one or more biological molecules in another organism (the \"target\" organism), initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt] synonym: "toxin receptor binding" EXACT [] xref: Wikipedia:Toxin is_a: GO:0003674 ! molecular_function created_by: tanyaberardini creation_date: 2016-12-19T15:23:27Z [Term] id: GO:0090730 name: Las1 complex namespace: cellular_component def: "A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448)." [GOC:vw, PMID:26638174] synonym: "Las1-Grc3-Rat1-Rai1" NARROW [GOC:vw] is_a: GO:1902555 ! endoribonuclease complex is_a: GO:1902911 ! protein kinase complex is_a: GO:1905354 ! exoribonuclease complex relationship: part_of GO:0005829 ! cytosol created_by: tanyaberardini creation_date: 2017-01-05T16:51:46Z [Term] id: GO:0090731 name: cellular response to very-low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus." [GOC:aruk, GOC:bc] synonym: "cellular response to VLDL particle stimulus" EXACT [] is_a: GO:0055094 ! response to lipoprotein particle is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus created_by: tanyaberardini creation_date: 2017-01-31T17:10:08Z [Term] id: GO:0090732 name: cofilin-actin rod namespace: cellular_component def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers." [GOC:sl, PMID:22573689, PMID:24760020] is_a: GO:0031002 ! actin rod created_by: tanyaberardini creation_date: 2017-01-31T17:44:04Z [Term] id: GO:0090733 name: tenascin complex namespace: cellular_component def: "A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R." [GOC:bhm, PMID:11731446, PMID:12845616, PMID:17909022, PMID:23658023] comment: An example is Tenascin-N (Q9UQP3) in PMID:17909022 (IDA). synonym: "Tenascin-C" NARROW [] synonym: "Tenascin-N" NARROW [] synonym: "Tenascin-R" NARROW [] synonym: "Tenascin-W" NARROW [] synonym: "Tenascin-X" NARROW [] xref: IntAct:EBI-11789587 xref: IntAct:EBI-13640819 is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: tanyaberardini creation_date: 2017-02-01T16:29:55Z [Term] id: GO:0090734 name: site of DNA damage namespace: cellular_component def: "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] xref: Wikipedia:DNA_repair is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome created_by: tanyaberardini creation_date: 2017-02-03T17:24:08Z [Term] id: GO:0090735 name: DNA repair complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex." [GOC:pg, PMID:27113759, PMID:27233470] is_a: GO:0065003 ! protein-containing complex assembly created_by: tanyaberardini creation_date: 2017-02-06T16:42:27Z [Term] id: GO:0090736 name: MATH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a meprin and TRAF homology (MATH) domain." [InterPro:IPR002083, PMID:22621901] is_a: GO:0019904 ! protein domain specific binding created_by: tanyaberardini creation_date: 2017-02-06T17:08:28Z [Term] id: GO:0090737 name: telomere maintenance via telomere trimming namespace: biological_process def: "A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:27918544] is_a: GO:0000723 ! telomere maintenance created_by: tanyaberardini creation_date: 2017-02-07T16:51:24Z [Term] id: GO:0090740 name: integral component of pigment granule membrane namespace: cellular_component def: "The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [PMID:11294610] is_a: GO:0031301 ! integral component of organelle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0090741 ! pigment granule membrane relationship: part_of GO:0090741 ! pigment granule membrane created_by: tanyaberardini creation_date: 2017-05-16T17:48:35Z [Term] id: GO:0090741 name: pigment granule membrane namespace: cellular_component def: "Any membrane that is part of a pigment granule." [PMID:11294610] is_a: GO:0098588 ! bounding membrane of organelle created_by: tanyaberardini creation_date: 2017-05-16T22:33:39Z [Term] id: GO:0093001 name: glycolysis from storage polysaccharide through glucose-1-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH." [GOC:dph, GOC:glycolysis] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate [Term] id: GO:0093002 name: response to nematicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes." [GOC:kvm, PMID:22301316] synonym: "response to antihelmintic" EXACT [GOC:kvm] synonym: "response to nematocide" EXACT [GOC:kvm] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0095500 name: acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "acetylcholine receptor signalling pathway" EXACT [] is_a: GO:0098926 ! postsynaptic signal transduction is_a: GO:1903831 ! signal transduction involved in cellular response to ammonium ion relationship: part_of GO:1905145 ! cellular response to acetylcholine [Term] id: GO:0097001 name: ceramide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any ceramide, a class of lipids that is composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [CHEBI:17761, GOC:sart] is_a: GO:0033218 ! amide binding is_a: GO:0046625 ! sphingolipid binding created_by: paola creation_date: 2011-03-09T11:34:09Z [Term] id: GO:0097002 name: mitochondrial inner boundary membrane namespace: cellular_component def: "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane." [GOC:mcc, PMID:16054341, PMID:19019989] synonym: "inner bounding mitochondrial membrane" EXACT [NIF_Subcellular:sao18461326] xref: NIF_Subcellular:sao18461326 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005743 ! mitochondrial inner membrane created_by: paola creation_date: 2011-03-10T04:11:50Z [Term] id: GO:0097003 name: adipokinetic hormone receptor activity namespace: molecular_function def: "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity relationship: has_part GO:0055100 ! adiponectin binding relationship: has_part GO:0097004 ! adipokinetic hormone binding created_by: paola creation_date: 2011-03-14T10:24:08Z [Term] id: GO:0097004 name: adipokinetic hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding created_by: paola creation_date: 2011-03-14T12:50:02Z [Term] id: GO:0097005 name: adipokinetic hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] synonym: "AKH receptor binding" EXACT [] is_a: GO:0051428 ! peptide hormone receptor binding created_by: paola creation_date: 2011-03-14T12:58:19Z [Term] id: GO:0097006 name: regulation of plasma lipoprotein particle levels namespace: biological_process def: "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism." [GOC:BHF] synonym: "plasma lipoprotein particle homeostasis" NARROW [] is_a: GO:0050789 ! regulation of biological process created_by: paola creation_date: 2011-03-15T09:52:53Z [Term] id: GO:0097007 name: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone." [GOC:kad, MetaCyc:RXN-8620, PMID:21088219] synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT [] synonym: "TMTT synthase activity" EXACT [] xref: MetaCyc:RXN-8620 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: paola creation_date: 2011-03-16T04:37:20Z [Term] id: GO:0097008 name: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone." [GOC:kad, MetaCyc:RXN-8619, PMID:21088219] synonym: "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity" EXACT [] synonym: "DNMT synthase activity" RELATED [] xref: MetaCyc:RXN-8619 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: paola creation_date: 2011-03-17T10:38:01Z [Term] id: GO:0097009 name: energy homeostasis namespace: biological_process alt_id: GO:2000505 alt_id: GO:2000506 alt_id: GO:2000507 def: "Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751] synonym: "negative regulation of energy homeostasis" RELATED [] synonym: "positive regulation of energy homeostasis" RELATED [] synonym: "regulation of energy homeostasis" RELATED [] is_a: GO:0048871 ! multicellular organismal homeostasis created_by: pr creation_date: 2011-03-21T10:52:44Z [Term] id: GO:0097010 name: eukaryotic translation initiation factor 4F complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex." [GOC:BHF, GOC:ebc, PMID:18337562] synonym: "eIF-4F assembly" EXACT [GOC:pr] synonym: "eIF4F assembly" EXACT [GOC:pr] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: paola creation_date: 2011-03-21T04:19:26Z [Term] id: GO:0097011 name: cellular response to granulocyte macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:BHF, GOC:ebc, PMID:7901744] synonym: "cellular response to GM-CSF stimulus" EXACT [] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0097012 ! response to granulocyte macrophage colony-stimulating factor created_by: paola creation_date: 2011-03-21T05:25:06Z [Term] id: GO:0097012 name: response to granulocyte macrophage colony-stimulating factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:pr] synonym: "response to GM-CSF" EXACT [] synonym: "response to granulocyte macrophage colony-stimulating factor stimulus" EXACT [GOC:dos] is_a: GO:0034097 ! response to cytokine created_by: paola creation_date: 2011-03-22T01:12:15Z [Term] id: GO:0097013 name: phagocytic vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs] is_a: GO:0071682 ! endocytic vesicle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0045335 ! phagocytic vesicle relationship: part_of GO:0045335 ! phagocytic vesicle created_by: paola creation_date: 2011-03-22T01:44:47Z [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005929 ! cilium relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097015 name: obsolete bacterial-type flagellar cytoplasm namespace: cellular_component def: "OBSOLETE. All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF] comment: The reason for obsoletion is that this term describes a cellular component that does not exist. synonym: "bacterial-type flagellum cytoplasm" EXACT [] is_obsolete: true created_by: paola creation_date: 2011-03-23T01:59:44Z [Term] id: GO:0097016 name: L27 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner." [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022] is_a: GO:0019904 ! protein domain specific binding created_by: paola creation_date: 2011-03-23T02:17:51Z [Term] id: GO:0097017 name: renal protein absorption namespace: biological_process def: "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:yaf, PMID:18431508] is_a: GO:0070293 ! renal absorption created_by: paola creation_date: 2011-03-23T03:13:04Z [Term] id: GO:0097018 name: renal albumin absorption namespace: biological_process def: "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508] is_a: GO:0097017 ! renal protein absorption created_by: paola creation_date: 2011-03-23T03:15:04Z [Term] id: GO:0097019 name: neurotransmitter receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors." [GOC:kmv] synonym: "neurotransmitter receptor breakdown" EXACT [] synonym: "neurotransmitter receptor catabolism" EXACT [] synonym: "neurotransmitter receptor degradation" EXACT [] is_a: GO:0032801 ! receptor catabolic process is_a: GO:0045213 ! neurotransmitter receptor metabolic process created_by: paola creation_date: 2011-03-23T04:16:11Z [Term] id: GO:0097020 name: COPII adaptor activity namespace: molecular_function def: "Bringing together a cargo protein with the COPII coat complex component to allow its uptake by the COPII vesicle." [GOC:rb, PMID:16957051, PMID:20236934] is_a: GO:0140312 ! cargo adaptor activity created_by: paola creation_date: 2011-03-24T04:19:55Z [Term] id: GO:0097021 name: lymphocyte migration into lymphoid organs namespace: biological_process def: "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] synonym: "lymphocyte homing" NARROW [] is_a: GO:0072676 ! lymphocyte migration created_by: paola creation_date: 2011-03-29T04:26:08Z [Term] id: GO:0097022 name: lymphocyte migration into lymph node namespace: biological_process def: "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] synonym: "lymphocyte homing" EXACT [] is_a: GO:0097021 ! lymphocyte migration into lymphoid organs created_by: paola creation_date: 2011-03-29T04:29:27Z [Term] id: GO:0097023 name: fructose 6-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate." [GOC:imk, PMID:11120740, PMID:21290439] xref: RHEA:28002 is_a: GO:0016832 ! aldehyde-lyase activity created_by: paola creation_date: 2011-03-29T04:54:05Z [Term] id: GO:0097025 name: MPP7-DLG1-LIN7 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions." [GOC:BHF, PMID:17237226] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005912 ! adherens junction created_by: paola creation_date: 2011-03-30T05:03:33Z [Term] id: GO:0097026 name: dendritic cell dendrite assembly namespace: biological_process def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351] comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. synonym: "dendritic extension" BROAD [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly created_by: paola creation_date: 2011-03-31T04:52:53Z [Term] id: GO:0097027 name: ubiquitin-protein transferase activator activity namespace: molecular_function def: "Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rb, PMID:18321851] is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity relationship: positively_regulates GO:0004842 ! ubiquitin-protein transferase activity created_by: paola creation_date: 2011-03-31T05:19:23Z [Term] id: GO:0097028 name: dendritic cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002521 ! leukocyte differentiation created_by: paola creation_date: 2011-04-01T10:08:42Z [Term] id: GO:0097029 name: mature conventional dendritic cell differentiation namespace: biological_process def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation created_by: paola creation_date: 2011-04-01T10:10:22Z [Term] id: GO:0097030 name: CENP-A containing nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:jp, PMID:21412236] synonym: "centromere-specific nucleosome binding" RELATED [GOC:vw] synonym: "centromeric nucleosome binding" RELATED [] is_a: GO:0031491 ! nucleosome binding created_by: paola creation_date: 2011-04-01T03:19:35Z [Term] id: GO:0097031 name: obsolete mitochondrial respiratory chain complex I biogenesis namespace: biological_process def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 is_obsolete: true created_by: paola creation_date: 2011-04-05T02:53:14Z [Term] id: GO:0097032 name: obsolete mitochondrial respiratory chain complex II biogenesis namespace: biological_process def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 is_obsolete: true created_by: paola creation_date: 2011-04-05T02:57:33Z [Term] id: GO:0097033 name: obsolete mitochondrial respiratory chain complex III biogenesis namespace: biological_process def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 synonym: "mitochondrial cytochrome bc(1) complex biogenesis" EXACT [GOC:pr] is_obsolete: true created_by: paola creation_date: 2011-04-05T03:00:31Z [Term] id: GO:0097034 name: obsolete mitochondrial respiratory chain complex IV biogenesis namespace: biological_process def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. See https://github.com/geneontology/go-ontology/issues/15173 synonym: "mitochondrial cytochrome c oxidase complex biogenesis" EXACT [GOC:pr] is_obsolete: true created_by: paola creation_date: 2011-04-05T03:02:54Z [Term] id: GO:0097035 name: regulation of membrane lipid distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0061024 ! membrane organization is_a: GO:0065008 ! regulation of biological quality created_by: paola creation_date: 2011-04-08T02:01:19Z [Term] id: GO:0097036 name: regulation of plasma membrane sterol distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [CHEBI:15889, GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0097035 ! regulation of membrane lipid distribution created_by: paola creation_date: 2011-04-08T02:08:08Z [Term] id: GO:0097037 name: heme export namespace: biological_process def: "The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401] is_a: GO:0015886 ! heme transport created_by: paola creation_date: 2011-04-11T10:39:22Z [Term] id: GO:0097038 name: perinuclear endoplasmic reticulum namespace: cellular_component def: "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "perinuclear ER" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0048471 ! perinuclear region of cytoplasm created_by: paola creation_date: 2011-04-12T10:51:05Z [Term] id: GO:0097039 name: protein linear polyubiquitination namespace: biological_process def: "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181] synonym: "M1 linkage" NARROW [] is_a: GO:0000209 ! protein polyubiquitination created_by: paola creation_date: 2011-04-13T01:52:51Z [Term] id: GO:0097040 name: phthiocerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents." [CHEBI:59240, GOC:dph, GOC:ecd, PMID:9201977] synonym: "phthiocerol anabolism" EXACT [] synonym: "phthiocerol biosynthesis" EXACT [] synonym: "phthiocerol formation" EXACT [] synonym: "phthiocerol synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0042845 ! glycol biosynthetic process created_by: paola creation_date: 2011-04-15T01:18:17Z [Term] id: GO:0097041 name: phenolic phthiocerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position." [CHEBI:59237, GOC:dph, GOC:ecd, PMID:9201977] synonym: "phenolic phthiocerol anabolism" EXACT [] synonym: "phenolic phthiocerol biosynthesis" EXACT [] synonym: "phenolic phthiocerol formation" EXACT [] synonym: "phenolic phthiocerol synthesis" EXACT [] synonym: "phenolphthiocerol biosynthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process created_by: paola creation_date: 2011-04-15T01:25:59Z [Term] id: GO:0097042 name: extrinsic component of fungal-type vacuolar membrane namespace: cellular_component def: "The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:jh, PMID:21454883] synonym: "extrinsic to fungal-type vacuolar membrane" NARROW [] is_a: GO:0000306 ! extrinsic component of vacuolar membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0000329 ! fungal-type vacuole membrane relationship: part_of GO:0000329 ! fungal-type vacuole membrane created_by: paola creation_date: 2011-04-19T03:42:39Z [Term] id: GO:0097043 name: histone H3-K56 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr] is_a: GO:0043966 ! histone H3 acetylation created_by: paola creation_date: 2011-04-19T05:18:29Z [Term] id: GO:0097044 name: histone H3-K56 acetylation in response to DNA damage namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell." [GOC:pr, GOC:vw, PMID:18344406] is_a: GO:0097043 ! histone H3-K56 acetylation relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus created_by: paola creation_date: 2011-04-19T05:22:54Z [Term] id: GO:0097045 name: phosphatidylserine exposure on blood platelet namespace: biological_process def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system." [GOC:bf, GOC:lf, GOC:pr, PMID:21107324] is_a: GO:0017121 ! plasma membrane phospholipid scrambling is_a: GO:0030194 ! positive regulation of blood coagulation created_by: paola creation_date: 2011-04-20T12:54:35Z [Term] id: GO:0097046 name: replication fork progression beyond termination site namespace: biological_process def: "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks." [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631] is_a: GO:2000621 ! regulation of DNA replication termination created_by: paola creation_date: 2011-05-03T03:34:01Z [Term] id: GO:0097047 name: DNA replication termination region namespace: cellular_component def: "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks." [GOC:mcc, GOC:pr, PMID:20797631] synonym: "TER" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome created_by: paola creation_date: 2011-05-03T03:38:40Z [Term] id: GO:0097048 name: dendritic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845] synonym: "dendritic cell apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process created_by: paola creation_date: 2011-05-04T02:18:59Z [Term] id: GO:0097049 name: motor neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086] synonym: "motoneuron apoptosis" EXACT [] synonym: "motor neuron apoptosis" NARROW [] is_a: GO:0051402 ! neuron apoptotic process created_by: paola creation_date: 2011-05-04T02:21:43Z [Term] id: GO:0097050 name: type B pancreatic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305] synonym: "pancreatic B cell apoptosis" EXACT [] synonym: "pancreatic beta cell apoptosis" EXACT [] synonym: "type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: paola creation_date: 2011-05-04T02:24:38Z [Term] id: GO:0097051 name: establishment of protein localization to endoplasmic reticulum membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane." [GOC:rb, PMID:9388185] synonym: "establishment of protein localisation in endoplasmic reticulum membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in endoplasmic reticulum membrane" EXACT [] is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum is_a: GO:0090150 ! establishment of protein localization to membrane created_by: paola creation_date: 2011-05-04T05:55:26Z [Term] id: GO:0097052 name: L-kynurenine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf] synonym: "L-kynurenine metabolism" EXACT [] is_a: GO:0070189 ! kynurenine metabolic process created_by: paola creation_date: 2011-05-24T03:28:44Z [Term] id: GO:0097053 name: L-kynurenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [CHEBI:16946, GOC:yaf] synonym: "L-kynurenine breakdown" EXACT [] synonym: "L-kynurenine catabolism" EXACT [] synonym: "L-kynurenine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0097052 ! L-kynurenine metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process created_by: paola creation_date: 2011-05-24T03:30:58Z [Term] id: GO:0097054 name: L-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf] synonym: "L-glutamate anabolism" EXACT [] synonym: "L-glutamate biosynthesis" EXACT [] synonym: "L-glutamate formation" EXACT [] synonym: "L-glutamate synthesis" EXACT [] is_a: GO:0006537 ! glutamate biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process created_by: paola creation_date: 2011-05-24T04:30:38Z [Term] id: GO:0097055 name: agmatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase." [CHEBI:17431, GOC:pr, GOC:yaf] synonym: "agmatine anabolism" EXACT [] synonym: "agmatine biosynthesis" EXACT [] synonym: "agmatine formation" EXACT [] synonym: "agmatine synthesis" EXACT [] is_a: GO:1901162 ! primary amino compound biosynthetic process created_by: paola creation_date: 2011-05-25T03:56:17Z [Term] id: GO:0097056 name: selenocysteinyl-tRNA(Sec) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [CHEBI:13166, GOC:yaf, PMID:15317934, UniPathway:UPA00906] synonym: "selenocysteinyl-tRNA(Sec) anabolism" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) biosynthesis" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) formation" EXACT [] synonym: "selenocysteinyl-tRNA(Sec) synthesis" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process created_by: paola creation_date: 2011-05-25T05:33:19Z [Term] id: GO:0097057 name: TRAF2-GSTP1 complex namespace: cellular_component def: "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses." [GOC:BHF, PMID:16636664] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2011-05-26T10:35:45Z [Term] id: GO:0097058 name: CRLF-CLCF1 complex namespace: cellular_component def: "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex." [GOC:BHF, PMID:10966616] synonym: "CLF-CLC complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: paola creation_date: 2011-05-26T10:37:55Z [Term] id: GO:0097059 name: CNTFR-CLCF1 complex namespace: cellular_component def: "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space." [GOC:BHF, PMID:11285233] synonym: "sCNTFR-CLC complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: paola creation_date: 2011-05-26T10:43:22Z [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] subset: goslim_synapse is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0045202 ! synapse relationship: part_of GO:0045202 ! synapse created_by: paola creation_date: 2011-06-07T11:22:09Z [Term] id: GO:0097061 name: dendritic spine organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] synonym: "dendritic spine organisation" EXACT [] is_a: GO:0099173 ! postsynapse organization is_a: GO:0106027 ! neuron projection organization created_by: paola creation_date: 2011-06-07T11:26:53Z [Term] id: GO:0097062 name: dendritic spine maintenance namespace: biological_process def: "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0097061 ! dendritic spine organization created_by: paola creation_date: 2011-06-07T11:29:03Z [Term] id: GO:0097063 name: cadmium ion sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)." [GOC:rs, PMID:19456862] is_a: GO:0046870 ! cadmium ion binding is_a: GO:0140299 ! small molecule sensor activity created_by: paola creation_date: 2011-06-08T09:46:14Z [Term] id: GO:0097064 name: ncRNA export from nucleus namespace: biological_process def: "The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm." [GOC:dgf, PMID:11352936] synonym: "non-coding RNA export from nucleus" EXACT [GOC:pr] is_a: GO:0006405 ! RNA export from nucleus created_by: paola creation_date: 2011-06-08T12:34:34Z [Term] id: GO:0097065 name: anterior head development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure." [GOC:yaf, PMID:14695376, PMID:15857913] is_a: GO:0060322 ! head development created_by: paola creation_date: 2011-06-08T12:38:11Z [Term] id: GO:0097066 name: response to thyroid hormone namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872] synonym: "response to thyroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone created_by: paola creation_date: 2011-06-14T05:01:18Z [Term] id: GO:0097067 name: cellular response to thyroid hormone stimulus namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0097066 ! response to thyroid hormone created_by: paola creation_date: 2011-06-14T05:02:47Z [Term] id: GO:0097068 name: response to thyroxine namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872] synonym: "response to T4" EXACT [Wikipedia:Thyroxine] synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine] synonym: "response to thyroxine stimulus" EXACT [GOC:dos] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid is_a: GO:0097066 ! response to thyroid hormone is_a: GO:1904386 ! response to L-phenylalanine derivative created_by: paola creation_date: 2011-06-14T05:05:07Z [Term] id: GO:0097069 name: cellular response to thyroxine stimulus namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872] synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097067 ! cellular response to thyroid hormone stimulus is_a: GO:0097068 ! response to thyroxine is_a: GO:1904387 ! cellular response to L-phenylalanine derivative created_by: paola creation_date: 2011-06-14T05:06:48Z [Term] id: GO:0097070 name: ductus arteriosus closure namespace: biological_process def: "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs." [GOC:hw] is_a: GO:0048844 ! artery morphogenesis created_by: paola creation_date: 2011-06-15T04:00:46Z [Term] id: GO:0097071 name: interferon regulatory factor complex namespace: cellular_component def: "A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit." [GOC:cna, PMID:20043992] synonym: "IRF complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2011-06-15T04:22:30Z [Term] id: GO:0097072 name: interferon regulatory factor 3 complex namespace: cellular_component def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3." [GOC:cna, PMID:12855817, PMID:14556004, Reactome:R-HSA-166272] synonym: "IRF3:IRF3 complex" EXACT [] is_a: GO:0097071 ! interferon regulatory factor complex created_by: paola creation_date: 2011-06-15T04:26:10Z [Term] id: GO:0097073 name: interferon regulatory factor 5 complex namespace: cellular_component def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5." [GOC:cna, PMID:12138184, PMID:16751392] synonym: "IRF5:IRF5 complex" EXACT [] is_a: GO:0097071 ! interferon regulatory factor complex created_by: paola creation_date: 2011-06-15T04:28:57Z [Term] id: GO:0097074 name: interferon regulatory factor 7 complex namespace: cellular_component def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:R-HSA-450344] synonym: "IRF7:IRF7 complex" EXACT [] is_a: GO:0097071 ! interferon regulatory factor complex created_by: paola creation_date: 2011-06-15T04:31:04Z [Term] id: GO:0097075 name: interferon regulatory factor 3-interferon regulatory factor 7 complex namespace: cellular_component def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:R-HSA-1027367] synonym: "IRF3:IRF7 complex" EXACT [] is_a: GO:0097071 ! interferon regulatory factor complex created_by: paola creation_date: 2011-06-15T04:33:36Z [Term] id: GO:0097076 name: transforming growth factor beta activated kinase 1 complex namespace: cellular_component def: "A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits)." [GOC:cna, PMID:16410796, PMID:17496917, PMID:18021073] synonym: "TAK1 kinase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2011-06-15T04:55:32Z [Term] id: GO:0097077 name: copper ion sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)." [GOC:rs, PMID:19928961] is_a: GO:0005507 ! copper ion binding is_a: GO:0140299 ! small molecule sensor activity created_by: paola creation_date: 2011-06-17T09:57:11Z [Term] id: GO:0097078 name: FAL1-SGD1 complex namespace: cellular_component def: "A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits." [GOC:rb, PMID:21576267] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2011-06-17T09:59:10Z [Term] id: GO:0097079 name: selenite:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)." [GOC:mcc, PMID:20861301] synonym: "selenite:H+ symporter activity" EXACT [] synonym: "selenite:hydrogen symporter activity" EXACT [] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity created_by: paola creation_date: 2011-06-17T10:01:11Z [Term] id: GO:0097080 name: plasma membrane selenite transport namespace: biological_process def: "The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane." [GOC:mcc, PMID:20861301] synonym: "plasma membrane hydrogenselenite transport" EXACT [] is_a: GO:0098656 ! anion transmembrane transport created_by: paola creation_date: 2011-06-17T10:03:55Z [Term] id: GO:0097081 name: vascular smooth muscle cell fate commitment namespace: biological_process def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] is_a: GO:0042693 ! muscle cell fate commitment relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation created_by: paola creation_date: 2011-06-20T03:51:52Z [Term] id: GO:0097082 name: vascular smooth muscle cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] is_a: GO:0042694 ! muscle cell fate specification relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment created_by: paola creation_date: 2011-06-20T03:56:21Z [Term] id: GO:0097083 name: vascular smooth muscle cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] is_a: GO:0007521 ! muscle cell fate determination relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment created_by: paola creation_date: 2011-06-20T04:00:28Z [Term] id: GO:0097084 name: vascular smooth muscle cell development namespace: biological_process def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] is_a: GO:0055001 ! muscle cell development relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation created_by: paola creation_date: 2011-06-20T04:03:08Z [Term] id: GO:0097085 name: interferon regulatory factor 3-interferon regulatory factor 5 complex namespace: cellular_component def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5." [GOC:cna, PMID:12138184] synonym: "IRF3:IRF5 complex" EXACT [] is_a: GO:0097071 ! interferon regulatory factor complex created_by: paola creation_date: 2011-06-21T06:30:30Z [Term] id: GO:0097086 name: amniotic stem cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone." [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells] is_a: GO:0072497 ! mesenchymal stem cell differentiation created_by: paola creation_date: 2011-06-22T11:17:52Z [Term] id: GO:0097087 name: interleukin-17A production namespace: biological_process def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001138, Wikipedia:Interleukin_17] synonym: "IL-17A production" EXACT [] is_a: GO:0032620 ! interleukin-17 production created_by: paola creation_date: 2011-06-23T11:31:10Z [Term] id: GO:0097088 name: interleukin-17F production namespace: biological_process def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001142, Wikipedia:Interleukin_17] synonym: "IL-17F production" EXACT [] is_a: GO:0032620 ! interleukin-17 production created_by: paola creation_date: 2011-06-23T11:32:59Z [Term] id: GO:0097089 name: methyl-branched fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain." [CHEBI:62499, GOC:rs, PMID:19933331] synonym: "methyl-branched fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process created_by: paola creation_date: 2011-07-01T01:06:15Z [Term] id: GO:0097090 name: presynaptic membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411] comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. synonym: "pre-synaptic membrane organization" EXACT [] synonym: "presynaptic membrane organisation" EXACT [] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0050808 ! synapse organization created_by: paola creation_date: 2011-07-04T01:45:30Z [Term] id: GO:0097091 name: synaptic vesicle clustering namespace: biological_process def: "The process that results in grouping synaptic vesicles in presynaptic structures." [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108] comment: Updated definition as requested by SynGO group, see https://github.com/geneontology/synapse/issues/163. subset: goslim_synapse is_a: GO:0097479 ! synaptic vesicle localization relationship: part_of GO:0099504 ! synaptic vesicle cycle created_by: paola creation_date: 2011-07-04T01:48:24Z [Term] id: GO:0097092 name: polyacyltrehalose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [CHEBI:62547, GOC:rs, PMID:19729090] synonym: "polyacyltrehalose metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process created_by: paola creation_date: 2011-07-05T01:58:28Z [Term] id: GO:0097093 name: polyacyltrehalose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [CHEBI:62547, GOC:rs, PMID:19729090] synonym: "polyacyltrehalose anabolism" EXACT [] synonym: "polyacyltrehalose biosynthesis" EXACT [] synonym: "polyacyltrehalose formation" EXACT [] synonym: "polyacyltrehalose synthesis" EXACT [] is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0097092 ! polyacyltrehalose metabolic process created_by: paola creation_date: 2011-07-05T02:01:08Z [Term] id: GO:0097094 name: craniofacial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060349 ! bone morphogenesis relationship: part_of GO:1904888 ! cranial skeletal system development created_by: paola creation_date: 2011-07-05T02:51:54Z [Term] id: GO:0097095 name: frontonasal suture morphogenesis namespace: biological_process def: "The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized." [GOC:pr, GOC:sl, PMID:12416537, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] synonym: "nasofrontal suture morphogenesis" EXACT [] is_a: GO:0097094 ! craniofacial suture morphogenesis created_by: paola creation_date: 2011-07-05T02:57:46Z [Term] id: GO:0097096 name: facial suture morphogenesis namespace: biological_process def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: GO:0097094 ! craniofacial suture morphogenesis created_by: paola creation_date: 2011-07-05T03:06:27Z [Term] id: GO:0097097 name: nasal suture morphogenesis namespace: biological_process def: "The process in which the nasal suture is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] synonym: "internasal suture morphogenesis" EXACT [] is_a: GO:0097096 ! facial suture morphogenesis created_by: paola creation_date: 2011-07-05T03:09:04Z [Term] id: GO:0097098 name: DNA/RNA hybrid annealing activity namespace: molecular_function def: "Facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops." [GOC:imk, PMID:21699496] is_a: GO:0071667 ! DNA/RNA hybrid binding is_a: GO:0097617 ! annealing activity created_by: paola creation_date: 2011-07-07T11:20:44Z [Term] id: GO:0097099 name: structural constituent of albumen namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo." [GOC:jj, Wikipedia:Albumen] synonym: "structural constituent of egg white" EXACT [] is_a: GO:0005198 ! structural molecule activity created_by: paola creation_date: 2011-07-07T02:12:51Z [Term] id: GO:0097100 name: supercoiled DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil] is_a: GO:0003690 ! double-stranded DNA binding created_by: paola creation_date: 2011-07-12T03:28:57Z [Term] id: GO:0097101 name: blood vessel endothelial cell fate specification namespace: biological_process def: "The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [CL:0002139, GOC:dgh, PMID:21521739] is_a: GO:0060847 ! endothelial cell fate specification relationship: part_of GO:0060846 ! blood vessel endothelial cell fate commitment created_by: paola creation_date: 2011-07-27T10:24:32Z [Term] id: GO:0097102 name: endothelial tip cell fate specification namespace: biological_process def: "The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels." [CL:0000704, GOC:dgh, PMID:21521739] synonym: "angiogenic tip cell fate specification" EXACT [] is_a: GO:0097101 ! blood vessel endothelial cell fate specification relationship: part_of GO:0002040 ! sprouting angiogenesis created_by: paola creation_date: 2011-07-27T10:29:00Z [Term] id: GO:0097103 name: endothelial stalk cell fate specification namespace: biological_process def: "The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout." [CL:0002671, GOC:dgh, PMID:21521739] synonym: "angiogenic stalk cell fate specification" EXACT [] is_a: GO:0097101 ! blood vessel endothelial cell fate specification relationship: part_of GO:0002040 ! sprouting angiogenesis created_by: paola creation_date: 2011-07-27T10:32:38Z [Term] id: GO:0097104 name: postsynaptic membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692] subset: goslim_synapse synonym: "post-synaptic membrane assembly" EXACT [] is_a: GO:0001941 ! postsynaptic membrane organization is_a: GO:0071709 ! membrane assembly relationship: part_of GO:0099068 ! postsynapse assembly created_by: paola creation_date: 2011-07-27T01:26:49Z [Term] id: GO:0097105 name: presynaptic membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748] comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. subset: goslim_synapse synonym: "pre-synaptic membrane assembly" EXACT [] is_a: GO:0071709 ! membrane assembly is_a: GO:0097090 ! presynaptic membrane organization relationship: part_of GO:0099054 ! presynapse assembly created_by: paola creation_date: 2011-07-27T01:30:45Z [Term] id: GO:0097106 name: postsynaptic density organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] synonym: "post synaptic density organization" EXACT [] synonym: "post-synaptic density organization" EXACT [] synonym: "postsynaptic density organisation" EXACT [] synonym: "PSD organization" EXACT [] is_a: GO:0099084 ! postsynaptic specialization organization created_by: paola creation_date: 2011-07-27T05:17:12Z [Term] id: GO:0097107 name: postsynaptic density assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] subset: goslim_synapse synonym: "post synaptic density assembly" EXACT [] synonym: "post-synaptic density assembly" EXACT [] synonym: "PSD assembly" EXACT [] is_a: GO:0097106 ! postsynaptic density organization is_a: GO:0098698 ! postsynaptic specialization assembly relationship: part_of GO:1904861 ! excitatory synapse assembly created_by: paola creation_date: 2011-07-27T05:21:39Z [Term] id: GO:0097108 name: hedgehog family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2011-07-28T10:06:45Z [Term] id: GO:0097109 name: neuroligin family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692] is_a: GO:0005102 ! signaling receptor binding created_by: paola creation_date: 2011-07-28T05:15:22Z [Term] id: GO:0097110 name: scaffold protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2011-07-28T05:16:53Z [Term] id: GO:0097111 name: endoplasmic reticulum-Golgi intermediate compartment organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment." [GOC:br, PMID:18287528] synonym: "endoplasmic reticulum-Golgi intermediate compartment organisation" EXACT [] synonym: "endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis" RELATED [] synonym: "ER-Golgi intermediate compartment organization" EXACT [] synonym: "ERGIC organization" EXACT [] is_a: GO:0006996 ! organelle organization created_by: paola creation_date: 2011-07-29T04:45:54Z [Term] id: GO:0097112 name: gamma-aminobutyric acid receptor clustering namespace: biological_process def: "The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359] synonym: "GABA receptor clustering" EXACT [] is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering relationship: part_of GO:0001941 ! postsynaptic membrane organization created_by: paola creation_date: 2011-07-31T05:21:08Z [Term] id: GO:0097113 name: AMPA glutamate receptor clustering namespace: biological_process def: "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785] synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [] synonym: "AMPA receptor clustering" EXACT [] is_a: GO:0097688 ! glutamate receptor clustering relationship: part_of GO:0001941 ! postsynaptic membrane organization created_by: paola creation_date: 2011-07-31T05:25:53Z [Term] id: GO:0097114 name: NMDA glutamate receptor clustering namespace: biological_process def: "The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359] synonym: "N-methyl-D-aspartate receptor clustering" EXACT [] synonym: "NMDA receptor clustering" EXACT [] is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering relationship: part_of GO:0001941 ! postsynaptic membrane organization created_by: paola creation_date: 2011-07-31T05:30:15Z [Term] id: GO:0097115 name: neurexin clustering involved in presynaptic membrane assembly namespace: biological_process def: "The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals." [GOC:BHF, GOC:sjp, PMID:12796785] synonym: "neurexin clustering" BROAD [] synonym: "Nrxn clustering" BROAD [] synonym: "presynaptic neurexin clustering" EXACT [] is_a: GO:0043113 ! receptor clustering intersection_of: GO:0043113 ! receptor clustering intersection_of: part_of GO:0097105 ! presynaptic membrane assembly relationship: part_of GO:0097105 ! presynaptic membrane assembly created_by: paola creation_date: 2011-07-31T05:40:00Z [Term] id: GO:0097116 name: gephyrin clustering involved in postsynaptic density assembly namespace: biological_process def: "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses." [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192] synonym: "Geph clustering" BROAD [] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0035418 ! protein localization to synapse intersection_of: part_of GO:0097107 ! postsynaptic density assembly relationship: part_of GO:0097107 ! postsynaptic density assembly created_by: paola creation_date: 2011-07-31T05:42:29Z [Term] id: GO:0097117 name: guanylate kinase-associated protein clustering namespace: biological_process def: "The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons." [GOC:BHF, GOC:sjp, PMID:15620359] synonym: "GKAP clustering" EXACT [] is_a: GO:0072657 ! protein localization to membrane relationship: part_of GO:0001941 ! postsynaptic membrane organization created_by: paola creation_date: 2011-07-31T05:44:35Z [Term] id: GO:0097118 name: neuroligin clustering involved in postsynaptic membrane assembly namespace: biological_process def: "The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons." [GOC:BHF, GOC:sjp, PMID:12796785] synonym: "neuroligin clustering" BROAD [] synonym: "Nlgn clustering" BROAD [] synonym: "postsynaptic neuroligin clustering" EXACT [] is_a: GO:0043113 ! receptor clustering intersection_of: GO:0043113 ! receptor clustering intersection_of: part_of GO:0097104 ! postsynaptic membrane assembly relationship: part_of GO:0097104 ! postsynaptic membrane assembly created_by: paola creation_date: 2011-07-31T05:47:25Z [Term] id: GO:0097119 name: postsynaptic density protein 95 clustering namespace: biological_process def: "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins." [GOC:BHF, GOC:sjp, PMID:10433269] synonym: "Dlg4 clustering" EXACT [] synonym: "post-synaptic density protein 95 clustering" EXACT [] synonym: "PSD-95 clustering" EXACT [] is_a: GO:0072657 ! protein localization to membrane relationship: part_of GO:0001941 ! postsynaptic membrane organization relationship: part_of GO:0097106 ! postsynaptic density organization created_by: paola creation_date: 2011-07-31T05:49:44Z [Term] id: GO:0097120 name: receptor localization to synapse namespace: biological_process def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273] synonym: "receptor localisation to synapse" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0035418 ! protein localization to synapse created_by: paola creation_date: 2011-07-31T09:20:30Z [Term] id: GO:0097121 name: cyclin A1-CDK1 complex namespace: cellular_component def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:41:25Z [Term] id: GO:0097122 name: cyclin A2-CDK1 complex namespace: cellular_component def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:42:24Z [Term] id: GO:0097123 name: cyclin A1-CDK2 complex namespace: cellular_component def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:43:18Z [Term] id: GO:0097124 name: cyclin A2-CDK2 complex namespace: cellular_component def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:44:19Z [Term] id: GO:0097125 name: cyclin B1-CDK1 complex namespace: cellular_component def: "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:45:15Z [Term] id: GO:0097126 name: cyclin B2-CDK1 complex namespace: cellular_component def: "A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:46:17Z [Term] id: GO:0097127 name: cyclin B3-CDK2 complex namespace: cellular_component def: "A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:47:16Z [Term] id: GO:0097128 name: cyclin D1-CDK4 complex namespace: cellular_component def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026740] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:48:36Z [Term] id: GO:0097129 name: cyclin D2-CDK4 complex namespace: cellular_component def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:53:15Z [Term] id: GO:0097130 name: cyclin D3-CDK4 complex namespace: cellular_component def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:54:17Z [Term] id: GO:0097131 name: cyclin D1-CDK6 complex namespace: cellular_component def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:55:26Z [Term] id: GO:0097132 name: cyclin D2-CDK6 complex namespace: cellular_component def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:56:34Z [Term] id: GO:0097133 name: cyclin D3-CDK6 complex namespace: cellular_component def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:57:41Z [Term] id: GO:0097134 name: cyclin E1-CDK2 complex namespace: cellular_component def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026745] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:58:42Z [Term] id: GO:0097135 name: cyclin E2-CDK2 complex namespace: cellular_component def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026746] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: paola creation_date: 2011-08-01T01:59:57Z [Term] id: GO:0097136 name: Bcl-2 family protein complex namespace: cellular_component def: "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2011-08-02T01:34:19Z [Term] id: GO:0097137 name: BAD-BCL-xl complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:36:06Z [Term] id: GO:0097138 name: BAD-BCL-2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:37:50Z [Term] id: GO:0097139 name: BID-BCL-2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:40:31Z [Term] id: GO:0097140 name: BIM-BCL-xl complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:41:30Z [Term] id: GO:0097141 name: BIM-BCL-2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:42:31Z [Term] id: GO:0097142 name: PUMA-BCL-2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:43:18Z [Term] id: GO:0097143 name: PUMA-BCL-xl complex namespace: cellular_component def: "A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:44:10Z [Term] id: GO:0097144 name: BAX complex namespace: cellular_component def: "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:45:15Z [Term] id: GO:0097145 name: BAK complex namespace: cellular_component def: "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:48:11Z [Term] id: GO:0097146 name: NOXA-BCL-xl complex namespace: cellular_component def: "A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:49:00Z [Term] id: GO:0097147 name: NOXA-BCL-2 complex namespace: cellular_component def: "A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:50:14Z [Term] id: GO:0097148 name: BCL-2 complex namespace: cellular_component def: "A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, GOC:so, PMID:14634621] is_a: GO:0097136 ! Bcl-2 family protein complex created_by: paola creation_date: 2011-08-02T01:51:16Z [Term] id: GO:0097149 name: centralspindlin complex namespace: cellular_component def: "A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0072686 ! mitotic spindle created_by: paola creation_date: 2011-08-04T11:15:37Z [Term] id: GO:0097150 name: neuronal stem cell population maintenance namespace: biological_process def: "Any process in by an organism or tissue maintains a population of neuronal stem cells." [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758] is_a: GO:0019827 ! stem cell population maintenance created_by: paola creation_date: 2011-08-04T11:18:28Z [Term] id: GO:0097151 name: positive regulation of inhibitory postsynaptic potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:BHF, GOC:sjp, PMID:18550748] synonym: "positive regulation of inhibitory post-synaptic membrane potential" EXACT [] synonym: "positive regulation of IPSP" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0098828 ! modulation of inhibitory postsynaptic potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0060080 ! inhibitory postsynaptic potential relationship: positively_regulates GO:0060080 ! inhibitory postsynaptic potential created_by: paola creation_date: 2011-08-12T10:07:45Z [Term] id: GO:0097152 name: mesenchymal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833] synonym: "mesenchymal cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-09-06T02:31:59Z [Term] id: GO:0097153 name: cysteine-type endopeptidase activity involved in apoptotic process namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis] synonym: "caspase activity" BROAD [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] xref: Reactome:R-HSA-6800797 "The PIDDosome activates CASP2" is_a: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: part_of GO:0006915 ! apoptotic process relationship: part_of GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-09-09T10:21:56Z [Term] id: GO:0097154 name: GABAergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269] is_a: GO:0030182 ! neuron differentiation created_by: paola creation_date: 2011-09-14T09:39:11Z [Term] id: GO:0097155 name: fasciculation of sensory neuron axon namespace: biological_process def: "The collection of sensory neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711] is_a: GO:0007413 ! axonal fasciculation created_by: paola creation_date: 2011-09-16T09:17:34Z [Term] id: GO:0097156 name: fasciculation of motor neuron axon namespace: biological_process def: "The collection of motor neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711] is_a: GO:0007413 ! axonal fasciculation created_by: paola creation_date: 2011-09-16T09:20:46Z [Term] id: GO:0097157 name: pre-mRNA intronic binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624] synonym: "pre-messenger RNA intronic binding" EXACT [] is_a: GO:0036002 ! pre-mRNA binding created_by: paola creation_date: 2011-09-23T11:27:01Z [Term] id: GO:0097158 name: pre-mRNA intronic pyrimidine-rich binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844] synonym: "pre-messenger RNA intronic pyrimidine-rich binding" EXACT [] is_a: GO:0097157 ! pre-mRNA intronic binding created_by: paola creation_date: 2011-09-23T11:29:03Z [Term] id: GO:0097159 name: organic cyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [CHEBI:33832, GOC:sjw, PMID:7583672] is_a: GO:0005488 ! binding created_by: paola creation_date: 2011-09-23T02:31:01Z [Term] id: GO:0097160 name: polychlorinated biphenyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [CHEBI:53156, GOC:sjw, PMID:7583672] synonym: "PCB binding" EXACT [] synonym: "polychlorobiphenyl binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding created_by: paola creation_date: 2011-09-23T02:33:22Z [Term] id: GO:0097161 name: DH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket." [GOC:yaf, InterPro:IPR000219, PMID:12775584] is_a: GO:0019904 ! protein domain specific binding created_by: paola creation_date: 2011-09-27T10:06:09Z [Term] id: GO:0097162 name: MADS box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs." [GOC:yaf, InterPro:IPR002100, PMID:18296735, Wikipedia:MADS-box] is_a: GO:0019904 ! protein domain specific binding created_by: paola creation_date: 2011-09-27T10:10:59Z [Term] id: GO:0097163 name: sulfur carrier activity namespace: molecular_function def: "Covalently binding to sulfur and delivering it to an acceptor molecule." [GOC:imk, PMID:16387657] comment: Moved and updated definition https://github.com/geneontology/go-ontology/issues/14455 is_a: GO:0140104 ! molecular carrier activity created_by: paola creation_date: 2011-09-27T10:15:41Z [Term] id: GO:0097164 name: ammonium ion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the ammonium ion." [CHEBI:35274, GOC:dhl, GOC:tb, PMID:14671018] synonym: "ammonium ion metabolism" EXACT [] synonym: "ammonium metabolic process" RELATED [] is_a: GO:0006807 ! nitrogen compound metabolic process created_by: paola creation_date: 2011-09-28T04:21:30Z [Term] id: GO:0097165 name: nuclear stress granule namespace: cellular_component def: "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:10359787, PMID:12865437] is_a: GO:0035770 ! ribonucleoprotein granule relationship: part_of GO:0005634 ! nucleus created_by: paola creation_date: 2011-09-28T07:49:55Z [Term] id: GO:0097166 name: lens epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [CL:0002224, GOC:yaf, PMID:18423449, Wikipedia:Lens_%28anatomy%29#Lens_epithelium] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0002088 ! lens development in camera-type eye created_by: paola creation_date: 2011-09-29T01:27:50Z [Term] id: GO:0097167 name: circadian regulation of translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215] synonym: "regulation of mRNA translation in response to circadian clock" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0007623 ! circadian rhythm is_a: GO:0032501 ! multicellular organismal process created_by: paola creation_date: 2011-09-29T03:13:31Z [Term] id: GO:0097168 name: mesenchymal stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0000134, GOC:yaf, PMID:20626275] synonym: "MSC proliferation" EXACT [] is_a: GO:0072089 ! stem cell proliferation created_by: paola creation_date: 2011-09-29T04:44:48Z [Term] id: GO:0097169 name: AIM2 inflammasome complex namespace: cellular_component def: "A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA." [GOC:vp, PMID:20303873] is_a: GO:0061702 ! inflammasome complex created_by: paola creation_date: 2011-10-03T07:36:21Z [Term] id: GO:0097170 name: ADP-L-glycero-beta-D-manno-heptose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [CHEBI:61530, GOC:yaf] synonym: "ADP-L-glycero-beta-D-manno-heptose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process created_by: paola creation_date: 2011-10-03T09:12:58Z [Term] id: GO:0097171 name: ADP-L-glycero-beta-D-manno-heptose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [CHEBI:61530, GOC:yaf, UniPathway:UPA00356] synonym: "ADP-L-glycero-beta-D-manno-heptose anabolism" EXACT [] synonym: "ADP-L-glycero-beta-D-manno-heptose biosynthesis" EXACT [] synonym: "ADP-L-glycero-beta-D-manno-heptose formation" EXACT [] synonym: "ADP-L-glycero-beta-D-manno-heptose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0097170 ! ADP-L-glycero-beta-D-manno-heptose metabolic process created_by: paola creation_date: 2011-10-03T09:15:03Z [Term] id: GO:0097172 name: N-acetylmuramic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [CHEBI:47978, GOC:yaf, PubChem_Compound:5462244] synonym: "N-acetylmuramate metabolic process" EXACT [] synonym: "N-acetylmuramate metabolism" EXACT [] synonym: "N-acetylmuramic acid metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process created_by: paola creation_date: 2011-10-07T12:45:24Z [Term] id: GO:0097173 name: N-acetylmuramic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [CHEBI:47978, GOC:yaf, PubChem_Compound:5462244, UniPathway:UPA00342] synonym: "N-acetylmuramate breakdown" EXACT [] synonym: "N-acetylmuramate catabolic process" EXACT [] synonym: "N-acetylmuramate catabolism" EXACT [] synonym: "N-acetylmuramate degradation" EXACT [] synonym: "N-acetylmuramic acid breakdown" EXACT [] synonym: "N-acetylmuramic acid catabolism" EXACT [] synonym: "N-acetylmuramic acid degradation" EXACT [] is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0097172 ! N-acetylmuramic acid metabolic process created_by: paola creation_date: 2011-10-07T12:48:47Z [Term] id: GO:0097174 name: 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [CHEBI:58690, GOC:yaf, PMID:15901686] synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolic process" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolism" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramic acid metabolism" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid metabolic process" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: paola creation_date: 2011-10-07T12:54:36Z [Term] id: GO:0097175 name: 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [CHEBI:58690, GOC:yaf, PMID:15901686, UniPathway:UPA00343] synonym: "1,6-anhydro-N-acetyl-beta-muramate breakdown" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolic process" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolism" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramate degradation" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramic acid breakdown" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramic acid catabolism" EXACT [] synonym: "1,6-anhydro-N-acetyl-beta-muramic acid degradation" EXACT [] synonym: "1,6-anhydro-N-acetylmuramate breakdown" EXACT [] synonym: "1,6-anhydro-N-acetylmuramate catabolic process" EXACT [] synonym: "1,6-anhydro-N-acetylmuramate catabolism" EXACT [] synonym: "1,6-anhydro-N-acetylmuramate degradation" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid breakdown" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid catabolic process" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid catabolism" EXACT [] synonym: "1,6-anhydro-N-acetylmuramic acid degradation" EXACT [] is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0097174 ! 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process created_by: paola creation_date: 2011-10-07T12:58:32Z [Term] id: GO:0097176 name: epoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [CHEBI:37407, GOC:rs, PMID:15822179] synonym: "epoxide metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: paola creation_date: 2011-10-10T11:29:49Z [Term] id: GO:0097177 name: mitochondrial ribosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell." [GOC:ans, PMID:20739282] is_a: GO:0043022 ! ribosome binding created_by: paola creation_date: 2011-10-11T03:03:03Z [Term] id: GO:0097178 name: ruffle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481] synonym: "membrane ruffle formation" EXACT [] synonym: "membrane ruffling" EXACT [] is_a: GO:0031529 ! ruffle organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly created_by: paola creation_date: 2011-10-16T01:46:09Z [Term] id: GO:0097179 name: protease inhibitor complex namespace: cellular_component def: "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity." [GOC:ans, PMID:6323392] synonym: "peptidase inhibitor complex" BROAD [] is_a: GO:1904090 ! peptidase inhibitor complex created_by: paola creation_date: 2011-10-16T08:53:44Z [Term] id: GO:0097180 name: serine protease inhibitor complex namespace: cellular_component def: "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity." [GOC:ans, PMID:6323392] synonym: "serine-type endopeptidase inhibitor complex" EXACT [GOC:bf, GOC:pr] synonym: "serpin complex" EXACT [] is_a: GO:0097179 ! protease inhibitor complex created_by: paola creation_date: 2011-10-16T08:55:17Z [Term] id: GO:0097181 name: protein C inhibitor-coagulation factor V complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V." [GOC:ans, PMID:6323392] synonym: "PCI-coagulation factor V complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-coagulation factor V complex" EXACT [PR:000014685] synonym: "protein C inhibitor-F5 complex" EXACT [PR:000007300] synonym: "serpin A5-coagulation factor V complex" EXACT [PR:000014685] synonym: "SERPINA5-coagulation factor V complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: paola creation_date: 2011-10-16T08:57:03Z [Term] id: GO:0097182 name: protein C inhibitor-coagulation factor Xa complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa." [GOC:ans, PMID:6323392] synonym: "PCI-coagulation factor Xa complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-coagulation factor Xa complex" EXACT [PR:000014685] synonym: "serpin A5-coagulation factor Xa complex" EXACT [PR:000014685] synonym: "SERPINA5-coagulation factor Xa complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: paola creation_date: 2011-10-16T09:01:29Z [Term] id: GO:0097183 name: protein C inhibitor-coagulation factor XI complex namespace: cellular_component def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI." [GOC:ans, PMID:2844223] synonym: "PCI-coagulation factor XI complex" EXACT [PR:000014685] synonym: "plasma serine protease inhibitor-coagulation factor XI complex" EXACT [PR:000014685] synonym: "protein C inhibitor-F11 complex" EXACT [PR:000007295] synonym: "serpin A5-coagulation factor XI complex" EXACT [PR:000014685] synonym: "SERPINA5-coagulation factor XI complex" EXACT [PR:000014685] is_a: GO:0097180 ! serine protease inhibitor complex created_by: paola creation_date: 2011-10-16T09:03:22Z [Term] id: GO:0097184 name: response to azide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [CHEBI:40910, GOC:yaf, PMID:16846222] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound created_by: paola creation_date: 2011-11-16T10:00:58Z [Term] id: GO:0097185 name: cellular response to azide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [CHEBI:40910, GOC:yaf, PMID:16846222] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0097184 ! response to azide is_a: GO:1901699 ! cellular response to nitrogen compound created_by: paola creation_date: 2011-11-16T10:04:41Z [Term] id: GO:0097186 name: amelogenesis namespace: biological_process def: "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] synonym: "enamel development" EXACT [] is_a: GO:0042475 ! odontogenesis of dentin-containing tooth is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis created_by: paola creation_date: 2011-11-21T09:01:24Z [Term] id: GO:0097187 name: dentinogenesis namespace: biological_process def: "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] synonym: "dentin development" EXACT [] synonym: "dentine development" EXACT [] is_a: GO:0042475 ! odontogenesis of dentin-containing tooth is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis created_by: paola creation_date: 2011-11-21T09:04:17Z [Term] id: GO:0097188 name: dentin mineralization namespace: biological_process def: "The process in which calcium salts are deposited into the calcareous tooth structure known as dentin." [GOC:sl, PMID:10206335, PMID:21196346] synonym: "dentine mineralization" EXACT [] is_a: GO:0034505 ! tooth mineralization relationship: part_of GO:0097187 ! dentinogenesis created_by: paola creation_date: 2011-11-21T09:05:43Z [Term] id: GO:0097189 name: apoptotic body namespace: cellular_component def: "A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um." [GOC:mtg_apoptosis, GOC:vesicles, http://en.wikipedia.org/wiki/Apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:15242875, PMID:24223256] synonym: "apoptotic bleb" RELATED [GOC:vesicles] synonym: "apoptotic vesicle" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle created_by: paola creation_date: 2011-11-22T08:05:20Z [Term] id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process alt_id: GO:0008624 def: "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-11-23T09:30:23Z [Term] id: GO:0097191 name: extrinsic apoptotic signaling pathway namespace: biological_process def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. synonym: "death receptor-mediated apoptosis" NARROW [] synonym: "extrinsic apoptosis" NARROW [] synonym: "extrinsic apoptotic pathway" EXACT [] synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW [] synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0097190 ! apoptotic signaling pathway created_by: paola creation_date: 2011-11-23T09:34:28Z [Term] id: GO:0097192 name: extrinsic apoptotic signaling pathway in absence of ligand namespace: biological_process def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] comment: For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154). synonym: "dependence receptor signaling pathway" RELATED [] synonym: "extrinsic apoptosis in absence of ligand" NARROW [] synonym: "extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] is_a: GO:0038034 ! signal transduction in absence of ligand is_a: GO:0097191 ! extrinsic apoptotic signaling pathway created_by: paola creation_date: 2011-11-23T09:37:09Z [Term] id: GO:0097193 name: intrinsic apoptotic signaling pathway namespace: biological_process alt_id: GO:0008629 def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] comment: The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595. synonym: "induction of apoptosis by intracellular signals" RELATED [] synonym: "intrinsic apoptosis" NARROW [] synonym: "intrinsic apoptotic pathway" EXACT [] synonym: "intrinsic apoptotic signalling pathway" EXACT [GOC:mah] synonym: "mitochondrial-mediated apoptotic pathway" EXACT [] is_a: GO:0035556 ! intracellular signal transduction is_a: GO:0097190 ! apoptotic signaling pathway created_by: paola creation_date: 2011-11-23T09:40:50Z [Term] id: GO:0097194 name: execution phase of apoptosis namespace: biological_process def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] synonym: "apoptosis" NARROW [] synonym: "execution phase of apoptotic process" EXACT [] is_a: GO:0009987 ! cellular process relationship: has_part GO:0032060 ! bleb assembly relationship: part_of GO:0006915 ! apoptotic process created_by: paola creation_date: 2011-11-23T09:45:24Z [Term] id: GO:0097195 name: pilomotor reflex namespace: biological_process def: "The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect." [GOC:BHF, http://en.wikipedia.org/wiki/Pilomotor_reflex, PMID:21335239] synonym: "goosebump reflex" EXACT [] synonym: "horripilation" EXACT [] synonym: "piloerection" EXACT [] is_a: GO:0060004 ! reflex created_by: paola creation_date: 2011-12-01T05:08:14Z [Term] id: GO:0097196 name: Shu complex namespace: cellular_component def: "A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932] is_a: GO:1990391 ! DNA repair complex created_by: paola creation_date: 2011-12-01T05:11:08Z [Term] id: GO:0097197 name: tetraspanin-enriched microdomain namespace: cellular_component def: "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities." [GOC:ans, PMID:19709882, PMID:21930792] synonym: "membrane tetraspanin-enriched microdomain" EXACT [] synonym: "TEM" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane created_by: paola creation_date: 2011-12-02T04:21:37Z [Term] id: GO:0097198 name: histone H3-K36 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059] is_a: GO:0010452 ! histone H3-K36 methylation is_a: GO:0018023 ! peptidyl-lysine trimethylation created_by: paola creation_date: 2011-12-05T01:19:45Z [Term] id: GO:0097199 name: cysteine-type endopeptidase activity involved in apoptotic signaling pathway namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase, PMID:11717445] comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases. synonym: "activator caspase activity" NARROW [] synonym: "apical caspase activity" NARROW [] synonym: "cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] synonym: "initiator caspase activity" NARROW [] is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process intersection_of: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: part_of GO:0097190 ! apoptotic signaling pathway relationship: part_of GO:0097190 ! apoptotic signaling pathway created_by: paola creation_date: 2011-12-12T01:43:00Z [Term] id: GO:0097200 name: cysteine-type endopeptidase activity involved in execution phase of apoptosis namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Caspase] comment: Examples of gene products that may be annotated to this term include CASP3, CASP6 and CASP7, also called effector (or executioner) caspases. synonym: "effector caspase activity" NARROW [] synonym: "executioner caspase activity" NARROW [] is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process intersection_of: GO:0004197 ! cysteine-type endopeptidase activity intersection_of: part_of GO:0097194 ! execution phase of apoptosis relationship: part_of GO:0097194 ! execution phase of apoptosis created_by: paola creation_date: 2011-12-12T01:46:06Z [Term] id: GO:0097201 name: negative regulation of transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:rn, PMID:11027285, PMID:15575969, PMID:16556235, PMID:18086556, PMID:18627600] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress created_by: paola creation_date: 2011-12-14T09:16:22Z [Term] id: GO:0097202 name: activation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810] comment: This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919. synonym: "activation of caspase activity" NARROW [] synonym: "activation of metacaspase activity" RELATED [] is_a: GO:0031638 ! zymogen activation is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity created_by: paola creation_date: 2011-12-19T02:44:04Z [Term] id: GO:0097203 name: phagocytic cup lip namespace: cellular_component def: "The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome." [GOC:pf, PMID:20200225] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0001891 ! phagocytic cup created_by: paola creation_date: 2011-12-21T10:26:41Z [Term] id: GO:0097204 name: phagocytic cup base namespace: cellular_component def: "The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking." [GOC:pf, PMID:20200225] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0001891 ! phagocytic cup created_by: paola creation_date: 2011-12-21T10:29:07Z [Term] id: GO:0097205 name: renal filtration namespace: biological_process def: "A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart] is_a: GO:0003014 ! renal system process created_by: paola creation_date: 2012-01-03T03:10:17Z [Term] id: GO:0097206 name: nephrocyte filtration namespace: biological_process def: "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] is_a: GO:0097205 ! renal filtration created_by: paola creation_date: 2012-01-03T03:13:31Z [Term] id: GO:0097207 name: bud dormancy process namespace: biological_process def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud." [GOC:PO_curators, PO_REF:00009] comment: Bud dormancy may precede dormancy of the whole plant. synonym: "bud dormancy" RELATED [] is_a: GO:0022611 ! dormancy process is_a: GO:0032501 ! multicellular organismal process created_by: paola creation_date: 2012-01-04T01:18:24Z [Term] id: GO:0097208 name: alveolar lamellar body namespace: cellular_component def: "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:cjm, http://en.wikipedia.org/wiki/Lamellar_granule] is_a: GO:0042599 ! lamellar body created_by: paola creation_date: 2012-01-04T02:33:04Z [Term] id: GO:0097209 name: epidermal lamellar body namespace: cellular_component def: "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:cjm, http://en.wikipedia.org/wiki/Lamellar_granule] is_a: GO:0042599 ! lamellar body created_by: paola creation_date: 2012-01-04T02:34:27Z [Term] id: GO:0097210 name: response to gonadotropin-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007] synonym: "response to GnRH" EXACT [] is_a: GO:0043434 ! response to peptide hormone created_by: paola creation_date: 2012-01-09T08:48:56Z [Term] id: GO:0097211 name: cellular response to gonadotropin-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007] synonym: "cellular response to GnRH" EXACT [] synonym: "cellular response to gonadotrophin-releasing hormone" EXACT [GOC:dph] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:0097210 ! response to gonadotropin-releasing hormone created_by: paola creation_date: 2012-01-09T08:51:23Z [Term] id: GO:0097212 name: lysosomal membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854] synonym: "lysosomal membrane organisation" EXACT [GOC:mah] synonym: "lysosome membrane organization" EXACT [] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0007040 ! lysosome organization created_by: paola creation_date: 2012-01-12T10:16:15Z [Term] id: GO:0097213 name: regulation of lysosomal membrane permeability namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] synonym: "regulation of lysosome membrane permeability" EXACT [] is_a: GO:0090559 ! regulation of membrane permeability is_a: GO:0097212 ! lysosomal membrane organization created_by: paola creation_date: 2012-01-12T10:19:44Z [Term] id: GO:0097214 name: positive regulation of lysosomal membrane permeability namespace: biological_process def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] synonym: "positive regulation of lysosome membrane permeability" EXACT [] is_a: GO:0097213 ! regulation of lysosomal membrane permeability is_a: GO:1905710 ! positive regulation of membrane permeability created_by: paola creation_date: 2012-01-12T10:22:17Z [Term] id: GO:0097215 name: negative regulation of lysosomal membrane permeability namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] synonym: "negative regulation of lysosome membrane permeability" EXACT [] is_a: GO:0097213 ! regulation of lysosomal membrane permeability is_a: GO:1905709 ! negative regulation of membrane permeability created_by: paola creation_date: 2012-01-12T10:23:42Z [Term] id: GO:0097216 name: guanosine tetraphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions." [CHEBI:17633, GOC:imk, PMID:15109491, PMID:16968770, PMID:18359660] synonym: "5'-ppGpp-3' binding" EXACT [] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding created_by: paola creation_date: 2012-01-13T08:35:50Z [Term] id: GO:0097217 name: sieve area namespace: cellular_component def: "A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements." [ISBN:0471738433, POC:curators] comment: Part of a sieve element (PO:0025406). is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009505 ! plant-type cell wall created_by: paola creation_date: 2012-01-13T05:39:03Z [Term] id: GO:0097218 name: sieve plate namespace: cellular_component def: "A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas." [ISBN:0471738433, POC:curators] comment: Typical of angiosperms. Part of sieve tube member (PO:0000289). is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097217 ! sieve area relationship: part_of GO:0009505 ! plant-type cell wall created_by: paola creation_date: 2012-01-13T05:42:48Z [Term] id: GO:0097219 name: compound sieve plate namespace: cellular_component def: "A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement." [ISBN:0471738433, POC:curators] comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. is_a: GO:0097218 ! sieve plate created_by: paola creation_date: 2012-01-13T05:45:23Z [Term] id: GO:0097220 name: simple sieve plate namespace: cellular_component def: "A sieve plate that contains a single specialized sieve area." [ISBN:0471738433, POC:curators] comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. is_a: GO:0097218 ! sieve plate created_by: paola creation_date: 2012-01-13T05:46:46Z [Term] id: GO:0097221 name: M/G1 phase-specific MADS box-forkhead transcription factor complex namespace: cellular_component def: "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2." [GOC:mah, PMID:18057023] synonym: "PBF complex" NARROW [] synonym: "PBF transcription complex" NARROW [GOC:vw] synonym: "PCB binding factor complex" NARROW [] synonym: "pombe cell cycle box binding factor complex" NARROW [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: paola creation_date: 2012-01-18T08:18:27Z [Term] id: GO:0097222 name: mitochondrial mRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails." [GOC:ans, PMID:18083837] is_a: GO:0006378 ! mRNA polyadenylation is_a: GO:0090616 ! mitochondrial mRNA 3'-end processing intersection_of: GO:0006378 ! mRNA polyadenylation intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: paola creation_date: 2012-01-24T02:47:19Z [Term] id: GO:0097223 name: obsolete sperm part namespace: cellular_component def: "OBSOLETE. Any constituent part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cjm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_obsolete: true consider: CL:0000019 created_by: paola creation_date: 2012-01-25T01:19:35Z [Term] id: GO:0097224 name: sperm connecting piece namespace: cellular_component def: "The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:21:02Z [Term] id: GO:0097225 name: sperm midpiece namespace: cellular_component def: "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:23:41Z [Term] id: GO:0097226 name: sperm mitochondrial sheath namespace: cellular_component def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:25:08Z [Term] id: GO:0097227 name: sperm annulus namespace: cellular_component def: "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity." [GOC:cjm, MP:0009834] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:26:17Z [Term] id: GO:0097228 name: sperm principal piece namespace: cellular_component def: "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:27:27Z [Term] id: GO:0097229 name: sperm end piece namespace: cellular_component def: "The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane." [GOC:cjm, GOC:sart, MP:0009837] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum created_by: paola creation_date: 2012-01-25T01:29:04Z [Term] id: GO:0097230 name: cell motility in response to potassium ion namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624] synonym: "K+ facilitation of cell motility" EXACT [] synonym: "potassium ion facilitation of cell motility" EXACT [] is_a: GO:0048870 ! cell motility relationship: part_of GO:0035865 ! cellular response to potassium ion created_by: paola creation_date: 2012-01-25T04:39:45Z [Term] id: GO:0097231 name: cell motility in response to calcium ion namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624, PMID:8937985] synonym: "Ca2+ facilitation of cell motility" EXACT [] synonym: "calcium ion facilitation of cell motility" EXACT [] is_a: GO:0048870 ! cell motility relationship: part_of GO:0071277 ! cellular response to calcium ion created_by: paola creation_date: 2012-01-25T04:42:45Z [Term] id: GO:0097232 name: lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:sl, PMID:11940594] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042599 ! lamellar body created_by: paola creation_date: 2012-01-26T10:28:42Z [Term] id: GO:0097233 name: alveolar lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:sl, PMID:11940594] is_a: GO:0097232 ! lamellar body membrane relationship: part_of GO:0097208 ! alveolar lamellar body created_by: paola creation_date: 2012-01-26T10:30:24Z [Term] id: GO:0097234 name: epidermal lamellar body membrane namespace: cellular_component def: "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:sl, PMID:11940594] is_a: GO:0097232 ! lamellar body membrane relationship: part_of GO:0097209 ! epidermal lamellar body created_by: paola creation_date: 2012-01-26T10:32:13Z [Term] id: GO:0097235 name: obsolete positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:1899286] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: paola creation_date: 2012-02-01T05:07:12Z [Term] id: GO:0097236 name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions." [GOC:dgf, PMID:19702872] comment: This entity was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: paola creation_date: 2012-02-01T09:33:11Z [Term] id: GO:0097237 name: cellular response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] is_a: GO:0009636 ! response to toxic substance is_a: GO:0070887 ! cellular response to chemical stimulus created_by: paola creation_date: 2012-02-02T12:23:31Z [Term] id: GO:0097238 name: cellular response to methylglyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:pr] is_a: GO:0051595 ! response to methylglyoxal is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1901655 ! cellular response to ketone created_by: paola creation_date: 2012-02-02T12:26:35Z [Term] id: GO:0097239 name: positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus." [GOC:dgf, PMID:15773992] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0097238 ! cellular response to methylglyoxal created_by: paola creation_date: 2012-02-02T12:28:46Z [Term] id: GO:0097240 name: chromosome attachment to the nuclear envelope namespace: biological_process def: "The process in which chromatin is anchored to the nuclear envelope." [GOC:vw, PMID:22156749] synonym: "attachment of chromatin to nuclear envelope" RELATED [] is_a: GO:0022402 ! cell cycle process is_a: GO:0050000 ! chromosome localization created_by: paola creation_date: 2012-02-07T01:11:37Z [Term] id: GO:0097241 name: hematopoietic stem cell migration to bone marrow namespace: biological_process def: "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:yaf, PMID:17368745] synonym: "hematopoietic stem cell homing" BROAD [] synonym: "hemopoietic stem cell migration to bone marrow" EXACT [] synonym: "progenitor cell homing" BROAD [] is_a: GO:0035701 ! hematopoietic stem cell migration created_by: paola creation_date: 2012-02-09T01:08:32Z [Term] id: GO:0097242 name: amyloid-beta clearance namespace: biological_process def: "The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors." [GOC:aruk, GOC:bc, GOC:BHF, PMID:18289866, PMID:19098903, PMID:26005850] synonym: "beta-amyloid clearance" EXACT [] is_a: GO:0032501 ! multicellular organismal process created_by: paola creation_date: 2012-02-16T05:32:29Z [Term] id: GO:0097243 name: flavonoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge." [CHEBI:47916, GOC:sl, PMID:20599706] is_a: GO:0005488 ! binding created_by: paola creation_date: 2012-02-17T03:49:16Z [Term] id: GO:0097244 name: flavonol binding namespace: molecular_function def: "Interacting selectively and non-covalently with a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone." [CHEBI:5078, GOC:sl] is_a: GO:0043168 ! anion binding is_a: GO:0097243 ! flavonoid binding created_by: paola creation_date: 2012-02-17T03:50:45Z [Term] id: GO:0097245 name: flavanol binding namespace: molecular_function def: "Interacting selectively and non-covalently with a flavanol." [CHEBI:24036, GOC:sl] synonym: "flavan-3-ol binding" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097243 ! flavonoid binding is_a: GO:1901363 ! heterocyclic compound binding created_by: paola creation_date: 2012-02-17T03:52:10Z [Term] id: GO:0097246 name: catechin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure." [CHEBI:23053, GOC:sl] is_a: GO:0097245 ! flavanol binding created_by: paola creation_date: 2012-02-17T03:53:54Z [Term] id: GO:0097247 name: epigallocatechin 3-gallate binding namespace: molecular_function def: "Interacting selectively and non-covalently with epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [CHEBI:4806, GOC:sl, PMID:21307292] synonym: "catechin gallate binding" BROAD [] synonym: "EGCG binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097243 ! flavonoid binding is_a: GO:1901363 ! heterocyclic compound binding created_by: paola creation_date: 2012-02-17T03:55:05Z [Term] id: GO:0097248 name: maintenance of protein location in cell cortex of cell tip namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell." [GOC:al, PMID:19646873] is_a: GO:0032065 ! maintenance of protein location in cell cortex created_by: paola creation_date: 2012-02-20T04:27:31Z [Term] id: GO:0097250 name: mitochondrial respirasome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701] comment: Changed label as requested\nhttps://github.com/geneontology/go-ontology/issues/12846 synonym: "mitochondrial respiratory chain supercomplex assembly" EXACT [] synonym: "mitochondrial respiratory supercomplex assembly" EXACT [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: paola creation_date: 2012-02-23T05:18:41Z [Term] id: GO:0097251 name: leukotriene B4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:yaf, UniPathway:UPA00878] synonym: "leukotriene B4 anabolism" EXACT [] synonym: "leukotriene B4 biosynthesis" EXACT [] synonym: "leukotriene B4 formation" EXACT [] synonym: "leukotriene B4 synthesis" EXACT [] synonym: "LTB4 anabolism" EXACT [] synonym: "LTB4 biosynthesis" EXACT [] synonym: "LTB4 formation" EXACT [] synonym: "LTB4 synthesis" EXACT [] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0019370 ! leukotriene biosynthetic process is_a: GO:0036102 ! leukotriene B4 metabolic process is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: paola creation_date: 2012-02-24T09:34:01Z [Term] id: GO:0097252 name: oligodendrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520] synonym: "oligodendrocyte apoptosis" NARROW [] is_a: GO:0034349 ! glial cell apoptotic process created_by: paola creation_date: 2012-03-05T10:51:15Z [Term] id: GO:0097253 name: beta-hydroxybutyrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid." [CHEBI:10983, GOC:dsf, PMID:22302940] synonym: "(R)-3-hydroxybutyrate transmembrane transporter activity" EXACT [] synonym: "3-hydroxybutanoic acid transmembrane transporter activity" EXACT [] is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity created_by: paola creation_date: 2012-03-05T01:22:37Z [Term] id: GO:0097254 name: renal tubular secretion namespace: biological_process def: "Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, http://en.wikipedia.org/wiki/Renal_secretion#Secretion, http://fau.pearlashes.com/anatomy/Chapter%2041B/Chapter%2041B.htm, PMID:10049739] is_a: GO:0003014 ! renal system process is_a: GO:0046903 ! secretion created_by: paola creation_date: 2012-03-05T02:03:58Z [Term] id: GO:0097255 name: R2TP complex namespace: cellular_component def: "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2012-03-06T11:16:33Z [Term] id: GO:0097256 name: phenyllactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidation of phenyllactate to produce phenylpyruvate." [GOC:pde, PMID:15421980] comment: This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU). is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: paola creation_date: 2012-03-07T11:39:39Z [Term] id: GO:0097257 name: leukotriene B4 12-hydroxy dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497] synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT [] xref: Reactome:R-HSA-2161567 "LTB4 is oxidised to 12-oxoLTB4 by PTGR1" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: paola creation_date: 2012-03-07T02:07:41Z [Term] id: GO:0097258 name: 20-hydroxy-leukotriene B4 omega oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + NADPH + H(+) = 20-aldehyde-leukotriene B4 + 2H2O + NADP(+)." [GOC:mw, PMID:2836406] synonym: "20-hydroxy-leukotriene B4 omega-oxidase activity" EXACT [] synonym: "20-hydroxy-leukotriene B4 omega-oxidation" RELATED [] xref: Reactome:R-HSA-2161745 "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: paola creation_date: 2012-03-07T03:37:53Z [Term] id: GO:0097259 name: 20-aldehyde-leukotriene B4 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 20-aldehyde-leukotriene B4 + O2 + NADPH + H(+) = 20-carboxy-leukotriene B4 + H2O + NADP(+)." [GOC:mw, PMID:2549038, PMID:2836406] xref: Reactome:R-HSA-2161792 "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3" xref: Reactome:R-HSA-2161979 "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH" is_a: GO:0004497 ! monooxygenase activity created_by: paola creation_date: 2012-03-07T03:40:05Z [Term] id: GO:0097260 name: eoxin A4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene A4 = eoxin A4." [GOC:mw, PMID:18184802, PMID:18647347] xref: Reactome:R-HSA-2162019 "LTA4 is converted to EXA4 by ALOX15" is_a: GO:0016853 ! isomerase activity created_by: paola creation_date: 2012-03-08T02:57:23Z [Term] id: GO:0097261 name: eoxin C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4." [GOC:mw, PMID:18184802, PMID:18647347] xref: Reactome:R-HSA-2161768 "EXA4 is converted to EXC4 by LTC4S" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: paola creation_date: 2012-03-08T02:59:00Z [Term] id: GO:0097262 name: eoxin D4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid." [GOC:mw, PMID:18184802, PMID:18647347] xref: Reactome:R-HSA-2161945 "EXC4 is converted to EXD4 by GGT" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups created_by: paola creation_date: 2012-03-08T03:01:00Z [Term] id: GO:0097263 name: eoxin E4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine." [GOC:mw, PMID:18184802, PMID:18647347] xref: Reactome:R-HSA-2161868 "EXD4 is converted to EXE4 by DPEP" is_a: GO:0008238 ! exopeptidase activity created_by: paola creation_date: 2012-03-08T03:02:48Z [Term] id: GO:0097264 name: self proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [GOC:yaf, PMID:18676612, PMID:19144634] synonym: "autolysis" BROAD [] synonym: "self-proteolysis" EXACT [] is_a: GO:0006508 ! proteolysis created_by: paola creation_date: 2012-03-09T12:43:24Z [Term] id: GO:0097265 name: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-HETE + NADP(+) = 5-oxo-ETE + NADPH + H(+)." [GOC:mw, PMID:1326548] synonym: "5(S)-HETE dehydrogenase activity" EXACT [] synonym: "5-HETE dehydrogenase activity" EXACT [] synonym: "5-hydroxy-eicosatetraenoic acid dehydrogenase activity" EXACT [] xref: Reactome:R-HSA-2161776 "5S-HETE is oxidised to 5-oxoETE by 5-HEDH" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: paola creation_date: 2012-03-09T12:46:02Z [Term] id: GO:0097266 name: phenylacetyl-CoA 1,2-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)." [EC:1.14.13.149, GOC:bf, GOC:gk, PMID:20660314, PMID:21247899] synonym: "phenylacetyl-CoA epoxidase activity" EXACT [GOC:bf] synonym: "phenylacetyl-CoA monooxygenase activity" EXACT [EC:1.14.13.149] synonym: "ring 1,2-phenylacetyl-CoA epoxidase activity" EXACT [EC:1.14.13.149] xref: EC:1.14.13.149 xref: KEGG_REACTION:R09838 xref: RHEA:32171 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: paola creation_date: 2012-03-13T09:22:47Z [Term] id: GO:0097267 name: omega-hydroxylase P450 pathway namespace: biological_process def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation." [GOC:mw, PMID:10681399] synonym: "P450 omega-hydroxylase pathway" EXACT [] is_a: GO:0019369 ! arachidonic acid metabolic process created_by: paola creation_date: 2012-03-15T12:58:15Z [Term] id: GO:0097268 name: cytoophidium namespace: cellular_component def: "A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, http://en.wikipedia.org/wiki/CTP_synthase#Cytoophidium, PMID:20513629, PMID:21930098] is_a: GO:0110165 ! cellular anatomical entity created_by: paola creation_date: 2012-03-15T01:00:20Z [Term] id: GO:0097269 name: all-trans-decaprenyl-diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate." [EC:2.5.1.91, GOC:mw, PMID:16262699] synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [] synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT [] xref: Reactome:R-HSA-2162253 "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: paola creation_date: 2012-03-20T01:00:23Z [Term] id: GO:0097270 name: dishabituation namespace: biological_process def: "The temporary recovery of response to a stimulus when a novel stimulus is added." [GOC:kmv, http://en.wikipedia.org/wiki/Habituation, PMID:11390637] is_a: GO:0046958 ! nonassociative learning created_by: paola creation_date: 2012-03-20T01:39:25Z [Term] id: GO:0097271 name: protein localization to bud neck namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a cellular bud neck." [GOC:rb, PMID:22344253] synonym: "protein localisation to bud neck" EXACT [GOC:mah] synonym: "protein localization to cellular bud neck" EXACT [] is_a: GO:0034613 ! cellular protein localization created_by: paola creation_date: 2012-03-20T03:39:20Z [Term] id: GO:0097272 name: ammonia homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of ammonia." [GOC:yaf, PMID:12695560] is_a: GO:0048878 ! chemical homeostasis created_by: paola creation_date: 2012-03-22T02:51:22Z [Term] id: GO:0097273 name: creatinine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of creatinine." [GOC:yaf, PMID:12695560] is_a: GO:0048878 ! chemical homeostasis created_by: paola creation_date: 2012-03-22T02:52:50Z [Term] id: GO:0097274 name: urea homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of urea." [GOC:yaf, PMID:12695560] is_a: GO:0048878 ! chemical homeostasis created_by: paola creation_date: 2012-03-22T02:53:39Z [Term] id: GO:0097275 name: cellular ammonia homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of ammonia at the level of the cell." [GOC:yaf, PMID:12695560] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0097272 ! ammonia homeostasis created_by: paola creation_date: 2012-03-22T02:54:38Z [Term] id: GO:0097276 name: cellular creatinine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell." [GOC:yaf, PMID:12695560] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0097273 ! creatinine homeostasis created_by: paola creation_date: 2012-03-22T02:55:46Z [Term] id: GO:0097277 name: cellular urea homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell." [GOC:yaf, PMID:12695560] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:0097274 ! urea homeostasis created_by: paola creation_date: 2012-03-22T02:57:08Z [Term] id: GO:0097278 name: complement-dependent cytotoxicity namespace: biological_process def: "Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complement proteins to that antibody." [GOC:add, GOC:rv] is_a: GO:0001906 ! cell killing relationship: has_part GO:0006956 ! complement activation created_by: paola creation_date: 2012-03-22T05:04:04Z [Term] id: GO:0097279 name: histamine secretion mediated by IgE immunoglobulin namespace: biological_process def: "Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen." [GOC:add, GOC:rv] synonym: "histamine secretion mediated by IgE antibody" EXACT [] synonym: "Ig-mediated histamine release" BROAD [] is_a: GO:0097280 ! histamine secretion mediated by immunoglobulin created_by: paola creation_date: 2012-03-22T06:42:13Z [Term] id: GO:0097280 name: histamine secretion mediated by immunoglobulin namespace: biological_process def: "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." [GOC:add, GOC:rv, PMID:11490155, PMID:1719184] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: has_part GO:0003823 ! antigen binding created_by: paola creation_date: 2012-03-26T01:30:25Z [Term] id: GO:0097281 name: immune complex formation namespace: biological_process def: "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." [GOC:add, GOC:rv] synonym: "antibody-mediated agglutination" EXACT [] is_a: GO:0016064 ! immunoglobulin mediated immune response relationship: has_part GO:0003823 ! antigen binding created_by: paola creation_date: 2012-03-26T01:35:21Z [Term] id: GO:0097282 name: immunoglobulin-mediated neutralization namespace: biological_process def: "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." [GOC:add, GOC:rv] synonym: "antibody-mediated neutralization" EXACT [] is_a: GO:0016064 ! immunoglobulin mediated immune response relationship: has_part GO:0003823 ! antigen binding created_by: paola creation_date: 2012-03-26T01:55:24Z [Term] id: GO:0097283 name: keratinocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527] synonym: "keratinocyte apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: paola creation_date: 2012-03-29T10:20:51Z [Term] id: GO:0097284 name: hepatocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020] synonym: "hepatocyte apoptosis" NARROW [] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: paola creation_date: 2012-03-29T10:23:21Z [Term] id: GO:0097285 name: obsolete cell-type specific apoptotic process namespace: biological_process def: "OBSOLETE. Any apoptotic process in a specific cell type." [GOC:mtg_apoptosis] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "cell-type specific apoptosis" NARROW [] is_obsolete: true consider: GO:0006915 created_by: paola creation_date: 2012-03-29T04:00:25Z [Term] id: GO:0097287 name: 7-cyano-7-deazaguanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [CHEBI:45075, GOC:yaf, PMID:364423] synonym: "7-cyano-7-deazaguanine metabolism" EXACT [] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0050898 ! nitrile metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: paola creation_date: 2012-04-25T10:50:50Z [Term] id: GO:0097288 name: 7-cyano-7-deazaguanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [CHEBI:45075, GOC:yaf, PMID:364423, UniPathway:UPA00391] synonym: "7-cyano-7-deazaguanine anabolism" EXACT [] synonym: "7-cyano-7-deazaguanine biosynthesis" EXACT [] synonym: "7-cyano-7-deazaguanine formation" EXACT [] synonym: "7-cyano-7-deazaguanine synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0080028 ! nitrile biosynthetic process is_a: GO:0097287 ! 7-cyano-7-deazaguanine metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: paola creation_date: 2012-04-25T10:53:47Z [Term] id: GO:0097289 name: alpha-ribazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [CHEBI:10329, GOC:yaf] synonym: "alpha-ribazole metabolism" EXACT [] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process created_by: paola creation_date: 2012-04-25T11:49:24Z [Term] id: GO:0097290 name: alpha-ribazole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [CHEBI:10329, GOC:yaf, MetaCyc:PWY-5508, MetaCyc:PWY-6269, UniPathway:UPA00061] synonym: "alpha-ribazole anabolism" EXACT [] synonym: "alpha-ribazole biosynthesis" EXACT [] synonym: "alpha-ribazole formation" EXACT [] synonym: "alpha-ribazole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0097289 ! alpha-ribazole metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process created_by: paola creation_date: 2012-04-25T11:51:07Z [Term] id: GO:0097291 name: renal phosphate ion absorption namespace: biological_process def: "A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:lb, PMID:18784102, PMID:22506049] synonym: "renal phosphate absorption" EXACT [] is_a: GO:0070293 ! renal absorption created_by: paola creation_date: 2012-04-25T03:34:48Z [Term] id: GO:0097292 name: XMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving XMP, xanthosine monophosphate." [CHEBI:15652, GOC:yaf] synonym: "XMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process created_by: paola creation_date: 2012-04-26T09:51:16Z [Term] id: GO:0097293 name: XMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate." [CHEBI:15652, GOC:yaf] synonym: "XMP anabolism" EXACT [] synonym: "XMP biosynthesis" EXACT [] synonym: "XMP formation" EXACT [] synonym: "XMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0097292 ! XMP metabolic process created_by: paola creation_date: 2012-04-26T09:54:13Z [Term] id: GO:0097294 name: 'de novo' XMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [CHEBI:15652, GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, UniPathway:UPA00601] synonym: "'de novo' XMP anabolism" EXACT [] synonym: "'de novo' XMP biosynthesis" EXACT [] synonym: "'de novo' XMP formation" EXACT [] synonym: "'de novo' XMP synthesis" EXACT [] is_a: GO:0097293 ! XMP biosynthetic process created_by: paola creation_date: 2012-04-26T09:57:49Z [Term] id: GO:0097295 name: morphine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [CHEBI:17303, GOC:yaf, UniPathway:UPA00852] synonym: "morphine anabolism" EXACT [] synonym: "morphine biosynthesis" EXACT [] synonym: "morphine formation" EXACT [] synonym: "morphine synthesis" EXACT [] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0071272 ! morphine metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process created_by: paola creation_date: 2012-05-02T09:51:19Z [Term] id: GO:0097296 name: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway namespace: biological_process def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway." [GOC:mtg_apoptosis] comment: Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. synonym: "activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [] synonym: "activation of initiator caspase activity" NARROW [] is_a: GO:2001269 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway created_by: paola creation_date: 2012-05-02T03:19:35Z [Term] id: GO:0097297 name: activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis namespace: biological_process def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis." [GOC:mtg_apoptosis] comment: Note that this term should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the execution phase of apoptosis (also known as an effector caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. synonym: "activation of effector caspase activity" NARROW [] is_a: GO:2001272 ! positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis created_by: paola creation_date: 2012-05-02T03:23:01Z [Term] id: GO:0097298 name: regulation of nucleus size namespace: biological_process def: "Any process that modulates the size of the nucleus." [GOC:al, GOC:mah, PMID:19366728] synonym: "regulation of nuclear size" EXACT [] synonym: "regulation of nuclear volume" EXACT [] is_a: GO:0032535 ! regulation of cellular component size created_by: paola creation_date: 2012-05-03T06:21:43Z [Term] id: GO:0097299 name: obsolete cysteine-type endopeptidase activity involved in plant-type hypersensitive response namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to plant-type hypersensitive response, the rapid, localized death of plant cells in response to invasion by a pathogen." [GOC:mtg_apoptosis] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "metacaspase activity involved in plant-type hypersensitive response" NARROW [] is_obsolete: true created_by: paola creation_date: 2012-05-04T02:09:55Z [Term] id: GO:0097300 name: programmed necrotic cell death namespace: biological_process def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595] comment: This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples. synonym: "programmed cell death by necrosis" EXACT [] synonym: "regulated necrosis" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0070265 ! necrotic cell death created_by: paola creation_date: 2012-05-04T03:03:39Z [Term] id: GO:0097301 name: regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:20412803] synonym: "cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" BROAD [] is_a: GO:0030007 ! cellular potassium ion homeostasis is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II created_by: paola creation_date: 2012-05-09T09:03:02Z [Term] id: GO:0097302 name: lipoprotein biosynthetic process via diacylglyceryl transfer namespace: biological_process def: "The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00664] synonym: "lipoprotein biosynthesis (diacylglyceryl transfer)" EXACT [] is_a: GO:0042158 ! lipoprotein biosynthetic process created_by: paola creation_date: 2012-05-15T01:02:02Z [Term] id: GO:0097303 name: lipoprotein biosynthetic process via N-acyl transfer namespace: biological_process def: "The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00666] synonym: "lipoprotein biosynthesis (N-acyl transfer)" EXACT [] is_a: GO:0042158 ! lipoprotein biosynthetic process created_by: paola creation_date: 2012-05-15T01:03:59Z [Term] id: GO:0097304 name: lipoprotein biosynthetic process via signal peptide cleavage namespace: biological_process def: "The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00665] synonym: "lipoprotein biosynthesis (signal peptide cleavage)" EXACT [] is_a: GO:0042158 ! lipoprotein biosynthetic process created_by: paola creation_date: 2012-05-15T01:05:17Z [Term] id: GO:0097305 name: response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-05-15T03:48:45Z [Term] id: GO:0097306 name: cellular response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0097305 ! response to alcohol is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: paola creation_date: 2012-05-15T03:49:51Z [Term] id: GO:0097307 name: response to farnesol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [CHEBI:28600, GOC:pr] is_a: GO:0033993 ! response to lipid is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol created_by: paola creation_date: 2012-05-15T03:51:31Z [Term] id: GO:0097308 name: cellular response to farnesol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [CHEBI:28600, GOC:di, PMID:11425711] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol is_a: GO:0097307 ! response to farnesol created_by: paola creation_date: 2012-05-15T03:54:01Z [Term] id: GO:0097309 name: cap1 mRNA methylation namespace: biological_process def: "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356] synonym: "cap1 mRNA capping" BROAD [] is_a: GO:0036451 ! cap mRNA methylation created_by: paola creation_date: 2012-05-23T04:03:13Z [Term] id: GO:0097310 name: cap2 mRNA methylation namespace: biological_process def: "Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA." [GOC:sp, PMID:20713356] synonym: "cap2 mRNA capping" BROAD [] is_a: GO:0036451 ! cap mRNA methylation created_by: paola creation_date: 2012-05-23T04:05:07Z [Term] id: GO:0097311 name: bacterial biofilm matrix namespace: cellular_component def: "A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672] is_a: GO:0062039 ! biofilm matrix created_by: paola creation_date: 2012-05-24T11:20:50Z [Term] id: GO:0097312 name: obsolete bacterial biofilm matrix component namespace: cellular_component def: "OBSOLETE. Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "biofilm matrix part" EXACT [] is_obsolete: true consider: GO:0097311 created_by: paola creation_date: 2012-05-24T11:22:56Z [Term] id: GO:0097313 name: bacterial biofilm matrix surface namespace: cellular_component def: "The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, http://en.wikipedia.org/wiki/Biofilm, PMID:22571672] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097311 ! bacterial biofilm matrix created_by: paola creation_date: 2012-05-24T11:25:47Z [Term] id: GO:0097314 name: apoptosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process." [GOC:mtg_apoptosis] synonym: "apoptosome formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0097190 ! apoptotic signaling pathway created_by: paola creation_date: 2012-05-28T03:39:49Z [Term] id: GO:0097315 name: response to N-acetyl-D-glucosamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [CHEBI:506227, GOC:di, PMID:21700702] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-05-30T03:58:54Z [Term] id: GO:0097316 name: cellular response to N-acetyl-D-glucosamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [CHEBI:506227, GOC:di, PMID:21700702] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0097315 ! response to N-acetyl-D-glucosamine is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: paola creation_date: 2012-05-30T04:01:02Z [Term] id: GO:0097317 name: invasive growth in response to biotic stimulus namespace: biological_process def: "The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus." [GOC:di, PMID:18679170] is_a: GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus is_a: GO:0036267 ! invasive filamentous growth created_by: paola creation_date: 2012-05-31T10:38:16Z [Term] id: GO:0097318 name: invasive growth in response to abiotic stimulus namespace: biological_process def: "The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans." [GOC:di, PMID:18679170] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0036267 ! invasive filamentous growth created_by: paola creation_date: 2012-05-31T10:39:31Z [Term] id: GO:0097320 name: plasma membrane tubulation namespace: biological_process def: "A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103] synonym: "membrane tubulation" BROAD [] synonym: "vesicle scission" RELATED [] is_a: GO:0007009 ! plasma membrane organization created_by: paola creation_date: 2012-05-31T10:01:22Z [Term] id: GO:0097321 name: cell growth mode switching, filamentous to budding namespace: biological_process def: "The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans." [GOC:di, PMID:14617167] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells created_by: paola creation_date: 2012-06-05T11:28:06Z [Term] id: GO:0097322 name: 7SK snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533] synonym: "7SK small nuclear RNA binding" EXACT [] is_a: GO:0017069 ! snRNA binding created_by: paola creation_date: 2012-06-05T11:42:23Z [Term] id: GO:0097323 name: B cell adhesion namespace: biological_process def: "The attachment of a B cell to another cell via adhesion molecules." [GOC:jc] is_a: GO:0007159 ! leukocyte cell-cell adhesion created_by: paola creation_date: 2012-06-06T01:59:19Z [Term] id: GO:0097324 name: melanocyte migration namespace: biological_process def: "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532] is_a: GO:0010631 ! epithelial cell migration created_by: paola creation_date: 2012-06-08T10:08:18Z [Term] id: GO:0097325 name: melanocyte proliferation namespace: biological_process def: "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532] is_a: GO:0050673 ! epithelial cell proliferation created_by: paola creation_date: 2012-06-08T10:10:12Z [Term] id: GO:0097326 name: melanocyte adhesion namespace: biological_process def: "The attachment of a melanocyte to another cell via adhesion molecules." [CL:0000148, GOC:uh, PMID:22637532] is_a: GO:0090136 ! epithelial cell-cell adhesion created_by: paola creation_date: 2012-06-08T10:12:03Z [Term] id: GO:0097327 name: response to antineoplastic agent namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms." [CHEBI:35610, GOC:pr] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-06-12T10:48:28Z [Term] id: GO:0097328 name: response to carboplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [CHEBI:31355, GOC:pr] is_a: GO:0097327 ! response to antineoplastic agent created_by: paola creation_date: 2012-06-12T10:50:34Z [Term] id: GO:0097329 name: response to antimetabolite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [CHEBI:35221, GOC:pr] is_a: GO:0042221 ! response to chemical created_by: paola creation_date: 2012-06-12T10:52:01Z [Term] id: GO:0097330 name: response to 5-fluoro-2'-deoxyuridine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [CHEBI:60761, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-06-12T10:53:35Z [Term] id: GO:0097331 name: response to cytarabine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [CHEBI:28680, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1903416 ! response to glycoside created_by: paola creation_date: 2012-06-12T10:55:29Z [Term] id: GO:0097332 name: response to antipsychotic drug namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [CHEBI:35476, GOC:pr] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-06-12T10:58:13Z [Term] id: GO:0097333 name: response to olanzapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [CHEBI:7735, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:00:04Z [Term] id: GO:0097334 name: response to perphenazine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [CHEBI:8028, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:01:14Z [Term] id: GO:0097335 name: response to quetiapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [CHEBI:8707, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:03:22Z [Term] id: GO:0097336 name: response to risperidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [CHEBI:8871, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: paola creation_date: 2012-06-12T11:04:31Z [Term] id: GO:0097337 name: response to ziprasidone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [CHEBI:10119, GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:05:31Z [Term] id: GO:0097338 name: response to clozapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [CHEBI:3766, GOC:pr] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097332 ! response to antipsychotic drug created_by: paola creation_date: 2012-06-12T11:07:01Z [Term] id: GO:0097339 name: glycolate transmembrane transport namespace: biological_process def: "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [CHEBI:29805, GOC:am, PMID:11283302, PMID:11785976] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "glycolate membrane transport" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1900866 ! glycolate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: paola creation_date: 2012-06-12T05:12:35Z [Term] id: GO:0097340 name: inhibition of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739] synonym: "inhibition of caspase activity" NARROW [] synonym: "prevention of caspase activity" NARROW [] synonym: "prevention of cysteine-type endopeptidase activity" EXACT [] is_a: GO:0097341 ! zymogen inhibition is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity created_by: paola creation_date: 2012-06-18T11:23:05Z [Term] id: GO:0097341 name: zymogen inhibition namespace: biological_process def: "Any process that prevents the proteolytic processing of an inactive enzyme to an active form." [GOC:mtg_apoptosis, PMID:20383739] synonym: "prevention of zymogen activation" EXACT [] is_a: GO:0010955 ! negative regulation of protein processing created_by: paola creation_date: 2012-06-18T11:25:45Z [Term] id: GO:0097342 name: ripoptosome namespace: cellular_component def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400] comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330). synonym: "necrosome" RELATED [] synonym: "TNFR1 complex II" NARROW [PMID:22089168] synonym: "Tnfr1-CII" NARROW [PMID:22089168] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005829 ! cytosol created_by: paola creation_date: 2012-06-18T12:55:34Z [Term] id: GO:0097343 name: ripoptosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:mtg_apoptosis, PMID:22274400] is_a: GO:0065003 ! protein-containing complex assembly created_by: paola creation_date: 2012-06-18T12:57:20Z [Term] id: GO:0097344 name: Rix1 complex namespace: cellular_component def: "A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes." [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875] synonym: "IPI complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2012-06-18T01:38:49Z [Term] id: GO:0097345 name: mitochondrial outer membrane permeabilization namespace: biological_process def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309] comment: BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively). synonym: "mitochondrial outer membrane permeabilization" BROAD [] synonym: "mitochondrial outer membrane permeabilization during apoptotic cell death" BROAD [] synonym: "MOMP" EXACT [] is_a: GO:1902110 ! positive regulation of mitochondrial membrane permeability involved in apoptotic process relationship: part_of GO:0097190 ! apoptotic signaling pathway created_by: paola creation_date: 2012-06-19T04:06:54Z [Term] id: GO:0097346 name: INO80-type complex namespace: cellular_component def: "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: paola creation_date: 2012-06-20T11:26:55Z [Term] id: GO:0097347 name: TAM protein secretion complex namespace: cellular_component def: "A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane." [GOC:am, PMID:22466966] synonym: "translocation and assembly module protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2012-06-21T10:44:15Z [Term] id: GO:0097348 name: host cell endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a host cell endocytic vesicle." [GOC:ecd] is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane created_by: paola creation_date: 2012-06-25T10:31:34Z [Term] id: GO:0097350 name: neutrophil clearance namespace: biological_process def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127] is_a: GO:0048771 ! tissue remodeling relationship: has_part GO:0006909 ! phagocytosis relationship: part_of GO:0001780 ! neutrophil homeostasis created_by: paola creation_date: 2012-06-27T03:53:38Z [Term] id: GO:0097351 name: toxin-antitoxin pair type II binding namespace: molecular_function def: "Interacting selectively and non-covalently with a toxic protein, disabling its function. There may be more than one antitoxin to a toxic protein. Instances of this activity are known only in prokaryotes, where the toxic protein may be a ribonuclease, a DNA gyrase, or other." [GOC:rs, http://en.wikipedia.org/wiki/Toxin-antitoxin_system#Type_II, PMID:19143615, PMID:19325885, PMID:21819231, PMID:22545240] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2012-06-28T11:41:38Z [Term] id: GO:0097352 name: autophagosome maturation namespace: biological_process alt_id: GO:0000046 def: "Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293] synonym: "autophagic vacuole fusion" EXACT [GOC:autophagy] synonym: "autophagic vacuole maturation" EXACT [GOC:autophagy] synonym: "autophagosome fusion" RELATED [] is_a: GO:0032984 ! protein-containing complex disassembly relationship: part_of GO:0016236 ! macroautophagy created_by: paola creation_date: 2012-06-28T03:12:18Z [Term] id: GO:0097353 name: centrolateral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment." [GOC:dsz] synonym: "mediolateral pattern formation" EXACT [] is_a: GO:0003002 ! regionalization created_by: paola creation_date: 2012-07-02T11:34:08Z [Term] id: GO:0097354 name: prenylation namespace: biological_process def: "The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, PMID:18029206, PMID:21351751, PMID:22123822, PMID:22642693, PMID:22660767] is_a: GO:0044237 ! cellular metabolic process created_by: paola creation_date: 2012-07-03T01:12:19Z [Term] id: GO:0097355 name: protein localization to heterochromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin created_by: paola creation_date: 2012-07-03T03:19:07Z [Term] id: GO:0097356 name: perinucleolar compartment namespace: cellular_component def: "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC." [GOC:vw, http://en.wikipedia.org/wiki/Perinucleolar_compartment, PMID:21385875] synonym: "perinucleolar region" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031981 ! nuclear lumen created_by: paola creation_date: 2012-07-03T05:11:01Z [Term] id: GO:0097358 name: D-leucyl-tRNA(Leu) deacylase activity namespace: molecular_function def: "Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)." [GOC:se, PMID:10918062] is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity created_by: paola creation_date: 2012-07-04T09:18:12Z [Term] id: GO:0097359 name: UDP-glucosylation namespace: biological_process def: "The covalent attachment of a UDP-glucose residue to a substrate molecule." [GOC:al] is_a: GO:0006011 ! UDP-glucose metabolic process created_by: paola creation_date: 2012-07-06T02:26:35Z [Term] id: GO:0097360 name: chorionic trophoblast cell proliferation namespace: biological_process def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278] is_a: GO:0008283 ! cell population proliferation created_by: paola creation_date: 2012-07-19T10:17:37Z [Term] id: GO:0097361 name: CIA complex namespace: cellular_component def: "The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362] synonym: "cytosolic iron-sulfur protein assembly complex" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: paola creation_date: 2012-07-20T02:07:22Z [Term] id: GO:0097362 name: MCM8-MCM9 complex namespace: cellular_component def: "A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links." [GOC:sp, PMID:22771115, PMID:22771120] is_a: GO:0042555 ! MCM complex created_by: paola creation_date: 2012-07-20T02:10:12Z [Term] id: GO:0097363 name: protein O-GlcNAc transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [EC:2.4.1.255, GOC:jsg, GOC:sart, PMID:22158438] synonym: "O-GlcNAc transferase" EXACT [] synonym: "O-linked N-acetylglucosaminyltransferase" EXACT [] synonym: "OGTase" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase" EXACT [] is_a: GO:0008194 ! UDP-glycosyltransferase activity created_by: paola creation_date: 2012-07-24T01:46:51Z [Term] id: GO:0097364 name: stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758] is_a: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity intersection_of: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity intersection_of: regulates GO:0001508 ! action potential relationship: regulates GO:0001508 ! action potential created_by: paola creation_date: 2012-07-25T04:08:33Z [Term] id: GO:0097365 name: stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758] is_a: GO:0097364 ! stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential intersection_of: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential relationship: regulates GO:0086001 ! cardiac muscle cell action potential created_by: paola creation_date: 2012-07-26T02:39:10Z [Term] id: GO:0097366 name: response to bronchodilator namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [CHEBI:35523, GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to bronchodilator agent" EXACT [] synonym: "response to broncholytic agent" RELATED [] is_a: GO:0042493 ! response to drug created_by: paola creation_date: 2012-08-01T16:13:31Z [Term] id: GO:0097367 name: carbohydrate derivative binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carbohydrate derivative." [GOC:pr] subset: goslim_agr subset: goslim_mouse is_a: GO:0005488 ! binding created_by: paola creation_date: 2012-08-02T13:03:39Z [Term] id: GO:0097368 name: establishment of Sertoli cell barrier namespace: biological_process def: "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions." [GOC:sl, http://en.wikipedia.org/wiki/Blood-testis_barrier, PMID:19509333] synonym: "establishment of blood-testis barrier" EXACT [] synonym: "establishment of BTB" EXACT [] synonym: "establishment of SCB" EXACT [] is_a: GO:0060009 ! Sertoli cell development created_by: paola creation_date: 2012-08-02T17:05:55Z [Term] id: GO:0097370 name: protein O-GlcNAcylation via threonine namespace: biological_process def: "The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438] is_a: GO:0018243 ! protein O-linked glycosylation via threonine is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: paola creation_date: 2012-08-06T16:57:37Z [Term] id: GO:0097371 name: MDM2/MDM4 family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53." [InterPro:IPR016495] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2012-08-08T16:20:59Z [Term] id: GO:0097372 name: NAD-dependent histone deacetylase activity (H3-K18 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [EC:3.5.1.17, GOC:sp, PMID:22722849, RHEA:24548] is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific) created_by: paola creation_date: 2012-09-05T13:16:39Z [Term] id: GO:0097373 name: MCM core complex namespace: cellular_component def: "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated." [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914] synonym: "MCM4/6/7 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2012-09-12T10:41:42Z [Term] id: GO:0097374 name: sensory neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr] is_a: GO:0007411 ! axon guidance created_by: paola creation_date: 2012-10-01T10:16:22Z [Term] id: GO:0097375 name: spinal sensory neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord." [CL:0009000, GOC:pr, GOC:yaf] is_a: GO:0097374 ! sensory neuron axon guidance created_by: paola creation_date: 2012-10-01T10:17:20Z [Term] id: GO:0097376 name: interneuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions." [CL:0000099, GOC:pr] is_a: GO:0007411 ! axon guidance created_by: paola creation_date: 2012-10-01T10:18:35Z [Term] id: GO:0097377 name: spinal cord interneuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord." [CL:0005000, GOC:pr] is_a: GO:0097376 ! interneuron axon guidance created_by: paola creation_date: 2012-10-01T10:19:42Z [Term] id: GO:0097378 name: dorsal spinal cord interneuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord." [GOC:yaf] synonym: "dorsal interneuron axon guidance" EXACT [] is_a: GO:0097377 ! spinal cord interneuron axon guidance created_by: paola creation_date: 2012-10-01T10:20:48Z [Term] id: GO:0097379 name: dorsal spinal cord interneuron posterior axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367] synonym: "dorsal interneuron caudal axon projection" RELATED [] is_a: GO:0033564 ! anterior/posterior axon guidance is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance created_by: paola creation_date: 2012-10-01T10:22:38Z [Term] id: GO:0097380 name: dorsal spinal cord interneuron anterior axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367] synonym: "dorsal interneuron rostral axon projection" RELATED [] is_a: GO:0033564 ! anterior/posterior axon guidance is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance created_by: paola creation_date: 2012-10-01T10:24:41Z [Term] id: GO:0097381 name: photoreceptor disc membrane namespace: cellular_component def: "Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane." [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907] is_a: GO:0016020 ! membrane relationship: part_of GO:0001750 ! photoreceptor outer segment created_by: paola creation_date: 2012-10-05T11:01:22Z [Term] id: GO:0097382 name: deoxynucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate." [GOC:pde] is_a: GO:0016462 ! pyrophosphatase activity created_by: paola creation_date: 2012-10-11T16:03:22Z [Term] id: GO:0097383 name: dIDP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate." [GOC:pde, PMID:20385596] synonym: "deoxyinosine-diphosphatase activity" EXACT [] xref: Reactome:R-HSA-2509793 "NUDT16 hydrolyses dIDP to dIMP" is_a: GO:0097382 ! deoxynucleoside-diphosphatase activity created_by: paola creation_date: 2012-10-11T16:04:40Z [Term] id: GO:0097384 name: cellular lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells." [GOC:pr] synonym: "cellular lipid anabolism" EXACT [] synonym: "cellular lipid biosynthesis" EXACT [] synonym: "cellular lipid formation" EXACT [] synonym: "cellular lipid synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044255 ! cellular lipid metabolic process created_by: paola creation_date: 2012-10-16T16:47:09Z [Term] id: GO:0097385 name: programmed necrotic cell death in response to starvation namespace: biological_process def: "A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment)." [GOC:mtg_apoptosis, GOC:pg, PMID:13679856] synonym: "necrotic cell death in response to starvation" BROAD [] is_a: GO:0042594 ! response to starvation is_a: GO:0097300 ! programmed necrotic cell death created_by: paola creation_date: 2012-10-22T09:02:18Z [Term] id: GO:0097386 name: glial cell projection namespace: cellular_component def: "A prolongation or process extending from a glial cell." [GOC:mc] synonym: "glial process" RELATED [] synonym: "glial projection" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: paola creation_date: 2012-10-22T13:55:54Z [Term] id: GO:0097387 name: capitate projection namespace: cellular_component def: "Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies)." [GOC:mc, PMID:3098431] is_a: GO:0097386 ! glial cell projection created_by: paola creation_date: 2012-10-22T13:57:10Z [Term] id: GO:0097388 name: chemokine (C-C motif) ligand 19 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CCL19 production" EXACT [] synonym: "EBI1 ligand chemokine production" EXACT [] synonym: "ELC production" EXACT [] synonym: "macrophage inflammatory protein-3-beta production" EXACT [] synonym: "MIP-3-beta production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: paola creation_date: 2012-10-23T07:54:10Z [Term] id: GO:0097389 name: chemokine (C-C motif) ligand 21 production namespace: biological_process def: "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CCL21 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: paola creation_date: 2012-10-23T07:56:26Z [Term] id: GO:0097390 name: chemokine (C-X-C motif) ligand 12 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CXCL12 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: paola creation_date: 2012-10-23T07:57:28Z [Term] id: GO:0097391 name: chemokine (C-X-C motif) ligand 13 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CXCL13 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: paola creation_date: 2012-10-23T07:58:28Z [Term] id: GO:0097392 name: chemokine (C-X-C motif) ligand 16 production namespace: biological_process def: "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] synonym: "CXCL16 production" EXACT [] is_a: GO:0032602 ! chemokine production created_by: paola creation_date: 2012-10-23T07:59:43Z [Term] id: GO:0097393 name: telomeric repeat-containing RNA transcription namespace: biological_process def: "The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome." [GOC:al, PMID:22139915] synonym: "TERRA transcription" EXACT [PMID:22139915] is_a: GO:0006351 ! transcription, DNA-templated created_by: paola creation_date: 2012-10-23T10:06:17Z [Term] id: GO:0097394 name: telomeric repeat-containing RNA transcription by RNA polymerase II namespace: biological_process def: "The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter." [GOC:al, PMID:22139915] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "telomeric repeat-containing RNA transcription from RNA pol II promoter" EXACT [] synonym: "telomeric RNA transcription from Pol II promoter" RELATED [] synonym: "TERRA RNA transcription from RNA pol II promoter" RELATED [GOC:22139915] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0097393 ! telomeric repeat-containing RNA transcription created_by: paola creation_date: 2012-10-23T10:09:15Z [Term] id: GO:0097395 name: response to interleukin-32 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr] synonym: "response to IL-32" EXACT [] is_a: GO:0034097 ! response to cytokine created_by: paola creation_date: 2012-10-23T13:21:16Z [Term] id: GO:0097396 name: response to interleukin-17 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] synonym: "response to IL-17" EXACT [] is_a: GO:0034097 ! response to cytokine created_by: paola creation_date: 2012-10-23T13:22:28Z [Term] id: GO:0097397 name: cellular response to interleukin-32 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr] synonym: "cellular response to IL-32" EXACT [] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0097395 ! response to interleukin-32 created_by: paola creation_date: 2012-10-23T13:23:22Z [Term] id: GO:0097398 name: cellular response to interleukin-17 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] synonym: "cellular response to IL-17" EXACT [] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0097396 ! response to interleukin-17 created_by: paola creation_date: 2012-10-23T13:25:43Z [Term] id: GO:0097399 name: interleukin-32-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-32 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] synonym: "IL-32-mediated signaling pathway" EXACT [] synonym: "IL-32-mediated signalling pathway" EXACT [] synonym: "interleukin-32-mediated signalling pathway" EXACT [] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0097397 ! cellular response to interleukin-32 created_by: paola creation_date: 2012-10-23T13:27:22Z [Term] id: GO:0097400 name: interleukin-17-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-17 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] synonym: "IL-17-mediated signaling pathway" EXACT [] synonym: "IL-17-mediated signalling pathway" EXACT [] synonym: "interleukin-17-mediated signalling pathway" EXACT [] is_a: GO:0019221 ! cytokine-mediated signaling pathway relationship: part_of GO:0097398 ! cellular response to interleukin-17 created_by: paola creation_date: 2012-10-23T13:30:03Z [Term] id: GO:0097401 name: synaptic vesicle lumen acidification namespace: biological_process def: "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading." [GOC:dsf, PMID:21172605, PMID:22875945] subset: goslim_synapse synonym: "synaptic vesicle lumen pH reduction" EXACT [] synonym: "synaptic vesicle proton loading" EXACT syngo_official_label [] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0070050 ! neuron cellular homeostasis is_a: GO:1902600 ! proton transmembrane transport relationship: part_of GO:0016188 ! synaptic vesicle maturation relationship: part_of GO:0099504 ! synaptic vesicle cycle created_by: paola creation_date: 2012-10-25T09:03:34Z [Term] id: GO:0097402 name: neuroblast migration namespace: biological_process def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145] is_a: GO:0016477 ! cell migration created_by: paola creation_date: 2012-10-29T08:24:37Z [Term] id: GO:0097403 name: cellular response to raffinose namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:al] is_a: GO:0071322 ! cellular response to carbohydrate stimulus is_a: GO:1901545 ! response to raffinose created_by: paola creation_date: 2012-10-29T10:30:46Z [Term] id: GO:0097407 name: Bunina body namespace: cellular_component def: "Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles." [NIF_Subcellular:nlx_subcell_20090101, PMID:18026741] xref: NIF_Subcellular:nlx_subcell_20090101 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-10-31T13:52:30Z [Term] id: GO:0097408 name: fibrillary inclusion namespace: cellular_component def: "Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra." [NIF_Subcellular:sao967812059] xref: NIF_Subcellular:sao967812059 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-10-31T13:53:58Z [Term] id: GO:0097409 name: glial cytoplasmic inclusion namespace: cellular_component def: "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165] synonym: "GCI" EXACT [] synonym: "Papp-Lantos body" RELATED [] xref: NIF_Subcellular:nlx_subcell_20090703 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-10-31T13:55:11Z [Term] id: GO:0097410 name: hippocampal interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron." [CL:1001569, GOC:jc, PMID:19655320] is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0021895 ! cerebral cortex neuron differentiation relationship: part_of GO:0021766 ! hippocampus development created_by: paola creation_date: 2012-11-04T10:58:28Z [Term] id: GO:0097411 name: hypoxia-inducible factor-1alpha signaling pathway namespace: biological_process def: "A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia." [GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway] synonym: "HIF1alpha pathway" EXACT [] synonym: "hypoxia-inducible factor signaling" EXACT [GOC:bf] synonym: "hypoxia-inducible factor-1alpha signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071456 ! cellular response to hypoxia created_by: paola creation_date: 2012-11-06T10:46:33Z [Term] id: GO:0097412 name: hyaline inclusion namespace: cellular_component def: "A glass-like, pale intracellular inclusion." [NIF_Subcellular:nlx_subcell_20090104] synonym: "pale body" RELATED [] xref: NIF_Subcellular:nlx_subcell_20090104 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T16:24:58Z [Term] id: GO:0097413 name: Lewy body namespace: cellular_component def: "Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein." [NIF_Subcellular:sao4933778419] synonym: "cytoplasmic inclusion" RELATED [] xref: NIF_Subcellular:sao4933778419 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T16:26:08Z [Term] id: GO:0097414 name: classical Lewy body namespace: cellular_component def: "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545] synonym: "brainstem Lewy body" RELATED [] xref: NIF_Subcellular:sao4749542545 is_a: GO:0097413 ! Lewy body created_by: paola creation_date: 2012-11-06T16:27:41Z [Term] id: GO:0097415 name: cortical Lewy body namespace: cellular_component def: "Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils." [NIF_Subcellular:sao4040591221] xref: NIF_Subcellular:sao4040591221 is_a: GO:0097413 ! Lewy body created_by: paola creation_date: 2012-11-06T16:29:11Z [Term] id: GO:0097416 name: Lewy body-like hyaline inclusion namespace: cellular_component def: "Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments." [NIF_Subcellular:nlx_subcell_20090105, PMID:18026741] synonym: "LBHI" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090105 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T16:46:15Z [Term] id: GO:0097417 name: nematosome namespace: cellular_component def: "Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles." [NIF_Subcellular:sao138430598, PMID:5458990] xref: NIF_Subcellular:sao138430598 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T16:47:56Z [Term] id: GO:0097418 name: neurofibrillary tangle namespace: cellular_component def: "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926] comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). synonym: "flame-shaped neurofibrillary tangle" NARROW [] synonym: "star-shaped neurofibrillary tangle" NARROW [] xref: NIF_Subcellular:nlx_subcell_20090201 xref: NIF_Subcellular:nlx_subcell_20090202 xref: NIF_Subcellular:sao2409833926 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T16:49:35Z [Term] id: GO:0097419 name: Pick body namespace: cellular_component def: "Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E." [NIF_Subcellular:nlx_subcell_20090102] xref: NIF_Subcellular:nlx_subcell_20090102 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T20:57:02Z [Term] id: GO:0097420 name: skein-like inclusion namespace: cellular_component def: "Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin." [NIF_Subcellular:nlx_subcell_20090103, PMID:18026741] xref: NIF_Subcellular:nlx_subcell_20090103 is_a: GO:0016234 ! inclusion body created_by: paola creation_date: 2012-11-06T20:58:35Z [Term] id: GO:0097421 name: liver regeneration namespace: biological_process def: "The regrowth of lost or destroyed liver." [GOC:gap, PMID:19447520] is_a: GO:0001889 ! liver development is_a: GO:0031100 ! animal organ regeneration created_by: paola creation_date: 2012-11-07T10:22:43Z [Term] id: GO:0097422 name: tubular endosome namespace: cellular_component def: "A network of fine tubules in the vicinity of the Golgi complex and around the centriole." [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161] synonym: "coated tip" RELATED [] xref: NIF_Subcellular:sao1570660411 xref: NIF_Subcellular:sao694815499 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005768 ! endosome created_by: paola creation_date: 2012-11-07T13:36:26Z [Term] id: GO:0097423 name: mitochondrion-associated adherens complex namespace: cellular_component def: "An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans." [NIF_Subcellular:sao1933817066, PMID:20089910] synonym: "MAC" RELATED [] synonym: "mitochondrial adhaerens complex" EXACT [] xref: NIF_Subcellular:sao1933817066 is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005739 ! mitochondrion relationship: has_part GO:0005911 ! cell-cell junction created_by: paola creation_date: 2012-11-07T13:38:50Z [Term] id: GO:0097424 name: nucleolus-associated heterochromatin namespace: cellular_component def: "Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus." [NIF_Subcellular:sao1210952635] xref: NIF_Subcellular:sao1210952635 is_a: GO:0030874 ! nucleolar chromatin created_by: paola creation_date: 2012-11-07T13:43:17Z [Term] id: GO:0097425 name: obsolete smooth endoplasmic reticulum part namespace: cellular_component def: "OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER)." [NIF_Subcellular:sao184202831] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "SER subcomponent" RELATED [NIF_Subcellular:sao1842028314] xref: NIF_Subcellular:sao184202831 is_obsolete: true consider: GO:0005790 created_by: paola creation_date: 2012-11-07T13:45:14Z [Term] id: GO:0097426 name: glial filament namespace: cellular_component def: "An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes." [NIF_Subcellular:sao1863852493] xref: NIF_Subcellular:sao1863852493 is_a: GO:0005882 ! intermediate filament created_by: paola creation_date: 2012-11-07T14:59:55Z [Term] id: GO:0097427 name: microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] synonym: "microtubule fascicle" EXACT [] xref: NIF_Subcellular:sao1872343973 is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005874 ! microtubule relationship: part_of GO:0005856 ! cytoskeleton created_by: paola creation_date: 2012-11-07T15:01:27Z [Term] id: GO:0097428 name: protein maturation by iron-sulfur cluster transfer namespace: biological_process def: "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977] is_a: GO:0051604 ! protein maturation created_by: paola creation_date: 2012-11-15T09:59:06Z [Term] id: GO:0097429 name: amino acid ligation activity by nonribosomal peptide synthase namespace: molecular_function def: "Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase." [GOC:vw] is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process created_by: paola creation_date: 2012-11-16T12:34:22Z [Term] id: GO:0097430 name: copper ion import across prospore membrane namespace: biological_process def: "The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol." [GOC:al, GOC:vw, PMID:21828039] synonym: "copper ion import across prospore membrane" EXACT [] synonym: "copper ion import into ascospore-type prospore" RELATED [] synonym: "copper ion transport into forespores" RELATED [] is_a: GO:0015677 ! copper ion import is_a: GO:0035434 ! copper ion transmembrane transport created_by: paola creation_date: 2012-11-16T12:37:05Z [Term] id: GO:0097431 name: mitotic spindle pole namespace: cellular_component def: "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw] is_a: GO:0000922 ! spindle pole relationship: part_of GO:0072686 ! mitotic spindle created_by: paola creation_date: 2012-11-20T09:03:16Z [Term] id: GO:0097432 name: hippocampal pyramidal neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus." [CL:1001571, GOC:jc, PMID:19342486] is_a: GO:1905270 ! Meynert cell differentiation created_by: paola creation_date: 2012-11-22T09:33:31Z [Term] id: GO:0097433 name: dense body namespace: cellular_component def: "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736] xref: NIF_Subcellular:sao730872736 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: paola creation_date: 2012-11-22T15:34:04Z [Term] id: GO:0097434 name: succinate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)." [GOC:al, PMID:1293882] synonym: "succinate:hydrogen symporter activity" EXACT [] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity created_by: paola creation_date: 2012-11-26T18:19:42Z [Term] id: GO:0097435 name: supramolecular fiber organization namespace: biological_process alt_id: GO:0043206 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] synonym: "extracellular fibril organisation" NARROW [] synonym: "extracellular fibril organization" NARROW [] synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] synonym: "fibril organisation" RELATED [] synonym: "fibril organization" RELATED [] is_a: GO:0016043 ! cellular component organization created_by: paola creation_date: 2012-11-27T15:46:25Z [Term] id: GO:0097436 name: entry into dormancy namespace: biological_process def: "The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] synonym: "induction of dormancy" EXACT [] is_a: GO:0022611 ! dormancy process created_by: paola creation_date: 2012-12-05T14:55:49Z [Term] id: GO:0097437 name: maintenance of dormancy namespace: biological_process def: "The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] is_a: GO:0022611 ! dormancy process created_by: paola creation_date: 2012-12-05T15:00:24Z [Term] id: GO:0097438 name: exit from dormancy namespace: biological_process def: "The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] synonym: "release from dormancy" EXACT [] is_a: GO:0022611 ! dormancy process created_by: paola creation_date: 2012-12-05T15:01:24Z [Term] id: GO:0097439 name: acquisition of desiccation tolerance namespace: biological_process def: "The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state." [GOC:PO_curators] is_a: GO:0022611 ! dormancy process created_by: paola creation_date: 2012-12-05T15:09:52Z [Term] id: GO:0097440 name: apical dendrite namespace: cellular_component def: "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon." [NIF_Subcellular:sao273773228] xref: NIF_Subcellular:sao273773228 is_a: GO:0030425 ! dendrite created_by: paola creation_date: 2012-12-06T13:45:18Z [Term] id: GO:0097441 name: basal dendrite namespace: cellular_component def: "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681] synonym: "basilar dendrite" EXACT [NIF_Subcellular:sao1079900774] xref: NIF_Subcellular:sao1079900774 is_a: GO:0030425 ! dendrite created_by: paola creation_date: 2012-12-06T13:46:28Z [Term] id: GO:0097442 name: CA3 pyramidal cell dendrite namespace: cellular_component def: "A dendrite of a hippocampal CA3 pyramidal cell." [NIF_Subcellular:nlx_subcell_1005001] xref: NIF_Subcellular:nlx_subcell_1005001 is_a: GO:0030425 ! dendrite created_by: paola creation_date: 2012-12-06T13:47:23Z [Term] id: GO:0097443 name: sorting endosome namespace: cellular_component def: "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles." [NIF_Subcellular:sao1028571114] synonym: "MVB-tubule complex" RELATED [] xref: NIF_Subcellular:sao1028571114 is_a: GO:0005768 ! endosome created_by: paola creation_date: 2012-12-06T14:04:14Z [Term] id: GO:0097444 name: spine apparatus namespace: cellular_component def: "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748] subset: goslim_synapse synonym: "dense material" NARROW [NIF_Subcellular:sao1004601938] xref: NIF_Subcellular:sao725931194 is_a: GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0012505 ! endomembrane system relationship: part_of GO:0043197 ! dendritic spine created_by: paola creation_date: 2012-12-06T14:05:58Z [Term] id: GO:0097445 name: presynaptic active zone dense projection namespace: cellular_component def: "Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered." [NIF_Subcellular:sao494258938, PMID:15381754] synonym: "active zone dense projection" EXACT [] synonym: "pre-synaptic active zone dense projection" EXACT [] xref: NIF_Subcellular:sao494258938 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0048786 ! presynaptic active zone created_by: paola creation_date: 2012-12-06T14:08:21Z [Term] id: GO:0097446 name: protein localization to eisosome filament namespace: biological_process def: "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945] synonym: "protein localization to linear eisosome" EXACT [] is_a: GO:0044380 ! protein localization to cytoskeleton is_a: GO:0072697 ! protein localization to cell cortex created_by: paola creation_date: 2012-12-17T09:37:49Z [Term] id: GO:0097447 name: dendritic tree namespace: cellular_component def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] xref: NIF_Subcellular:sao172297168 is_a: GO:0043005 ! neuron projection relationship: has_part GO:0030425 ! dendrite relationship: part_of GO:0036477 ! somatodendritic compartment created_by: paola creation_date: 2012-12-17T12:31:49Z [Term] id: GO:0097448 name: spine mat namespace: cellular_component def: "A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma." [NIF_Subcellular:sao2128156969, PMID:10818137] xref: NIF_Subcellular:sao2128156969 is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0044309 ! neuron spine created_by: paola creation_date: 2012-12-17T12:34:16Z [Term] id: GO:0097449 name: astrocyte projection namespace: cellular_component def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580] synonym: "astrocyte process" EXACT [] synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894] synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993] xref: NIF_Subcellular:sao1630537580 is_a: GO:0097386 ! glial cell projection created_by: paola creation_date: 2012-12-17T13:29:55Z [Term] id: GO:0097450 name: astrocyte end-foot namespace: cellular_component def: "Terminal process of astrocyte abutting non-neuronal surfaces in the brain." [NIF_Subcellular:sao388182739] synonym: "astrocyte endfoot" EXACT [] xref: NIF_Subcellular:sao388182739 is_a: GO:0097449 ! astrocyte projection created_by: paola creation_date: 2012-12-17T13:33:55Z [Term] id: GO:0097451 name: glial limiting end-foot namespace: cellular_component def: "Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans." [NIF_Subcellular:sao181458425] synonym: "glial limiting endfoot" EXACT [] xref: NIF_Subcellular:sao181458425 is_a: GO:0097450 ! astrocyte end-foot created_by: paola creation_date: 2012-12-17T13:36:34Z [Term] id: GO:0097452 name: GAIT complex namespace: cellular_component def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094] synonym: "gamma interferon-activated inhibitor of translation complex" EXACT [] synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: paola creation_date: 2012-12-19T09:32:25Z [Term] id: GO:0097453 name: mesaxon namespace: cellular_component def: "Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide." [ISBN:0195065719, NIF_Subcellular:sao2127666702] synonym: "mesaxon of Schwann cell" NARROW [] xref: NIF_Subcellular:sao2127666702 is_a: GO:1990015 ! ensheathing process created_by: paola creation_date: 2012-12-19T12:59:13Z [Term] id: GO:0097454 name: Schwann cell microvillus namespace: cellular_component def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042] xref: NIF_Subcellular:sao1890444066 is_a: GO:0005902 ! microvillus is_a: GO:0097386 ! glial cell projection created_by: paola creation_date: 2012-12-19T13:01:02Z [Term] id: GO:0097455 name: spiny bracelet of Nageotte namespace: cellular_component def: "Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin." [NIF_Subcellular:sao937871668, PMID:15988042] xref: NIF_Subcellular:sao937871668 is_a: GO:0097386 ! glial cell projection created_by: paola creation_date: 2012-12-19T13:02:33Z [Term] id: GO:0097456 name: terminal loop namespace: cellular_component def: "Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath." [NIF_Subcellular:sao924713546] synonym: "terminal loop of Schwann cell" EXACT [] xref: NIF_Subcellular:sao924713546 is_a: GO:0097386 ! glial cell projection created_by: paola creation_date: 2012-12-19T13:04:06Z [Term] id: GO:0097457 name: hippocampal mossy fiber namespace: cellular_component def: "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709] xref: NIF_Subcellular:nlx_subcell_100312 is_a: GO:0044302 ! dentate gyrus mossy fiber created_by: paola creation_date: 2012-12-19T16:51:57Z [Term] id: GO:0097458 name: obsolete neuron part namespace: cellular_component def: "OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [GOC:pr, http://en.wikipedia.org/wiki/Neuron] subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon is_obsolete: true consider: CL:0000540 created_by: paola creation_date: 2012-12-19T16:53:50Z [Term] id: GO:0097462 name: Lewy neurite namespace: cellular_component def: "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597] xref: NIF_Subcellular:sao601362597 is_a: GO:0043005 ! neuron projection created_by: paola creation_date: 2012-12-21T07:57:58Z [Term] id: GO:0097463 name: gemmule namespace: cellular_component def: "Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex." [NIF_Subcellular:nlx_subcell_1005003] xref: NIF_Subcellular:nlx_subcell_1005003 is_a: GO:0043005 ! neuron projection created_by: paola creation_date: 2012-12-21T07:59:04Z [Term] id: GO:0097464 name: thorny excrescence namespace: cellular_component def: "Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads." [NIF_Subcellular:nlx_467, PMID:730852] xref: NIF_Subcellular:nlx_467 is_a: GO:0043197 ! dendritic spine created_by: paola creation_date: 2012-12-21T08:00:13Z [Term] id: GO:0097465 name: somatic spine namespace: cellular_component def: "Spine emanating from the cell soma of a neuron." [NIF_Subcellular:sao2048514053] xref: NIF_Subcellular:sao2048514053 is_a: GO:0044309 ! neuron spine created_by: paola creation_date: 2012-12-21T08:02:37Z [Term] id: GO:0097466 name: ubiquitin-dependent glycoprotein ERAD pathway namespace: biological_process def: "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177] synonym: "ER-associated glycoprotein degradation" EXACT [GOC:bf] synonym: "glycoprotein ERAD" EXACT [GOC:bf] synonym: "gpERAD" EXACT [PMID:25092655] synonym: "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0030433 ! ubiquitin-dependent ERAD pathway is_a: GO:1904587 ! response to glycoprotein created_by: paola creation_date: 2013-02-05T16:37:13Z [Term] id: GO:0097467 name: type III terminal bouton namespace: cellular_component def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones." [GOC:mc, PMID:10218156] synonym: "type III terminal button" EXACT [] is_a: GO:0043195 ! terminal bouton created_by: paola creation_date: 2013-02-06T09:39:18Z [Term] id: GO:0097468 name: programmed cell death in response to reactive oxygen species namespace: biological_process def: "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mtg_apoptosis] synonym: "PCD in response to oxidative stress" BROAD [] synonym: "PCD in response to reactive oxygen species" EXACT [] synonym: "programmed cell death in response to oxidative stress" BROAD [] synonym: "reactive oxygen species-mediated PCD" EXACT [] synonym: "reactive oxygen species-mediated programmed cell death" EXACT [] is_a: GO:0012501 ! programmed cell death is_a: GO:0036473 ! cell death in response to oxidative stress relationship: part_of GO:0034614 ! cellular response to reactive oxygen species created_by: paola creation_date: 2013-02-19T10:03:36Z [Term] id: GO:0097469 name: obsolete cyclin-dependent protein tyrosine kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit." [GOC:al, GOC:vw, PMID:1372994] comment: This term was made obsolete because it was added in error; the specific activity it refers to has never been observed. synonym: "cyclin-dependent protein tyrosine kinase activity" EXACT [] is_obsolete: true created_by: paola creation_date: 2013-02-19T12:42:11Z [Term] id: GO:0097470 name: ribbon synapse namespace: cellular_component def: "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm." [NIF_Subcellular:sao1884931180, PMID:15626493] synonym: "synapsis fasciolaris" EXACT [Wikipedia:Ribbon_synapse&oldid=757407851] xref: NIF_Subcellular:sao1884931180 is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: has_part GO:0098681 ! synaptic ribbon relationship: has_part GO:0098681 ! synaptic ribbon created_by: paola creation_date: 2013-02-21T07:40:01Z [Term] id: GO:0097471 name: mossy fiber rosette namespace: cellular_component def: "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes." [http://en.wikipedia.org/wiki/Mossy_fiber_(cerebellum), NIF_Subcellular:nlx_subcell_091021] subset: goslim_synapse synonym: "cerebellar mossy fiber to granule cell synapse" EXACT syngo_official_label [] xref: NIF_Subcellular:nlx_subcell_091021 is_a: GO:0032279 ! asymmetric synapse created_by: paola creation_date: 2013-02-21T07:42:52Z [Term] id: GO:0097472 name: cyclin-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr] is_a: GO:0004672 ! protein kinase activity relationship: has_part GO:0030332 ! cyclin binding relationship: part_of GO:0051726 ! regulation of cell cycle created_by: paola creation_date: 2013-03-06T13:46:04Z [Term] id: GO:0097473 name: retinal rod cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487] synonym: "rod photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process created_by: paola creation_date: 2013-03-21T09:44:45Z [Term] id: GO:0097474 name: retinal cone cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc] synonym: "cone photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process created_by: paola creation_date: 2013-03-21T09:46:22Z [Term] id: GO:0097475 name: motor neuron migration namespace: biological_process def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475] is_a: GO:0001764 ! neuron migration created_by: paola creation_date: 2013-04-23T13:00:46Z [Term] id: GO:0097476 name: spinal cord motor neuron migration namespace: biological_process def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475] is_a: GO:0097475 ! motor neuron migration created_by: paola creation_date: 2013-04-23T13:03:46Z [Term] id: GO:0097477 name: lateral motor column neuron migration namespace: biological_process def: "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [CL:0011002, GOC:yaf, PMID:20711475] is_a: GO:0097476 ! spinal cord motor neuron migration created_by: paola creation_date: 2013-04-23T13:05:32Z [Term] id: GO:0097478 name: leaflet of membrane bilayer namespace: cellular_component def: "Any of the two layers of lipid molecules that constitute a membrane." [GOC:cjm] synonym: "membrane leaflet" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016020 ! membrane created_by: paola creation_date: 2013-05-07T14:24:37Z [Term] id: GO:0097479 name: synaptic vesicle localization namespace: biological_process def: "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:pr] synonym: "establishment and maintenance of synaptic vesicle localization" EXACT [] synonym: "establishment and maintenance of synaptic vesicle position" EXACT [] synonym: "synaptic vesicle localisation" EXACT [] is_a: GO:0051648 ! vesicle localization created_by: paola creation_date: 2013-05-22T14:29:55Z [Term] id: GO:0097480 name: establishment of synaptic vesicle localization namespace: biological_process def: "The directed movement of a synaptic vesicle or vesicles to a specific location." [GOC:pr] synonym: "establishment of synaptic vesicle localisation" EXACT [] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0097479 ! synaptic vesicle localization created_by: paola creation_date: 2013-05-22T14:32:12Z [Term] id: GO:0097482 name: muscle cell postsynaptic specialization namespace: cellular_component def: "A postsynaptic specialization that is part of a neuromuscular junction." [GOC:pr] synonym: "muscle cell postsynaptic density" EXACT [] synonym: "muscle fiber postsynaptic density" EXACT [] is_a: GO:0099572 ! postsynaptic specialization intersection_of: GO:0099572 ! postsynaptic specialization intersection_of: part_of GO:0098975 ! postsynapse of neuromuscular junction relationship: part_of GO:0098975 ! postsynapse of neuromuscular junction created_by: paola creation_date: 2013-07-02T09:47:40Z [Term] id: GO:0097484 name: dendrite extension namespace: biological_process def: "Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl] is_a: GO:1990138 ! neuron projection extension created_by: paola creation_date: 2013-07-08T09:52:31Z [Term] id: GO:0097485 name: neuron projection guidance namespace: biological_process def: "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "neurite guidance" NARROW [] synonym: "neuron process guidance" EXACT [] synonym: "neuron protrusion guidance" EXACT [] synonym: "neuronal cell projection guidance" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component relationship: part_of GO:0006935 ! chemotaxis relationship: part_of GO:0048812 ! neuron projection morphogenesis created_by: paola creation_date: 2013-07-08T13:32:37Z [Term] id: GO:0097486 name: multivesicular body lumen namespace: cellular_component def: "The volume enclosed by the outermost membrane of a multivesicular body." [GOC:pde, PMID:21183070] is_a: GO:0031906 ! late endosome lumen relationship: part_of GO:0005771 ! multivesicular body created_by: paola creation_date: 2013-07-08T20:32:56Z [Term] id: GO:0097487 name: multivesicular body, internal vesicle namespace: cellular_component def: "A membrane-bounded vesicle wholly contained within a multivesicular body." [GOC:pde, PMID:21183070] is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0005771 ! multivesicular body created_by: paola creation_date: 2013-07-08T20:34:51Z [Term] id: GO:0097488 name: multivesicular body, internal vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a multivesicular body internal vesicle." [GOC:pde, PMID:21183070] is_a: GO:0012506 ! vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0097487 ! multivesicular body, internal vesicle created_by: paola creation_date: 2013-07-08T20:36:33Z [Term] id: GO:0097489 name: multivesicular body, internal vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of the multivesicular body internal vesicle." [GOC:pde, PMID:21183070] is_a: GO:0031983 ! vesicle lumen is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0097487 ! multivesicular body, internal vesicle created_by: paola creation_date: 2013-07-08T20:38:36Z [Term] id: GO:0097490 name: sympathetic neuron projection extension namespace: biological_process def: "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "sympathetic neurite extension" NARROW [] synonym: "sympathetic neuron process extension" EXACT [] synonym: "sympathetic neuron protrusion extension" EXACT [] synonym: "sympathetic neuronal cell projection extension" EXACT [] is_a: GO:1990138 ! neuron projection extension created_by: paola creation_date: 2013-07-10T11:47:53Z [Term] id: GO:0097491 name: sympathetic neuron projection guidance namespace: biological_process def: "The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "sympathetic neurite guidance" NARROW [] synonym: "sympathetic neuron process guidance" EXACT [] synonym: "sympathetic neuron protrusion guidance" EXACT [] synonym: "sympathetic neuronal cell projection guidance" EXACT [] is_a: GO:0097485 ! neuron projection guidance created_by: paola creation_date: 2013-07-10T11:49:21Z [Term] id: GO:0097492 name: sympathetic neuron axon guidance namespace: biological_process def: "The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "sympathetic neuron axon chemotaxis" RELATED [] synonym: "sympathetic neuron axon growth cone guidance" NARROW [] synonym: "sympathetic neuron axon pathfinding" EXACT [] is_a: GO:0007411 ! axon guidance created_by: paola creation_date: 2013-07-10T11:50:52Z [Term] id: GO:0097493 name: structural molecule activity conferring elasticity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling." [GOC:BHF, GOC:rl, PMID:23283722] is_a: GO:0005198 ! structural molecule activity created_by: paola creation_date: 2013-07-26T09:47:26Z [Term] id: GO:0097494 name: regulation of vesicle size namespace: biological_process def: "Any process that modulates the size of a vesicle." [GOC:pm, PMID:20007772] is_a: GO:0032535 ! regulation of cellular component size created_by: paola creation_date: 2013-08-06T11:48:51Z [Term] id: GO:0097495 name: H-NS-Hha complex namespace: cellular_component def: "A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:21600204] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990121 ! H-NS complex relationship: part_of GO:0005829 ! cytosol created_by: paola creation_date: 2013-08-08T14:37:33Z [Term] id: GO:0097496 name: blood vessel lumen ensheathment namespace: biological_process def: "A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel." [GOC:dgh, PMID:23698350] is_a: GO:0072554 ! blood vessel lumenization created_by: paola creation_date: 2013-08-12T13:46:45Z [Term] id: GO:0097497 name: blood vessel endothelial cell delamination namespace: biological_process def: "The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet." [GOC:dgh, PMID:23698350] is_a: GO:0060232 ! delamination created_by: paola creation_date: 2013-08-12T13:48:34Z [Term] id: GO:0097498 name: endothelial tube lumen extension namespace: biological_process def: "Any endothelial tube morphogenesis process by which the tube is increased in length." [GOC:dgh, PMID:23698350] is_a: GO:0061154 ! endothelial tube morphogenesis created_by: paola creation_date: 2013-08-12T13:49:54Z [Term] id: GO:0097499 name: protein localization to non-motile cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241] synonym: "protein localization to nonmotile primary cilium" RELATED [] is_a: GO:0061512 ! protein localization to cilium created_by: paola creation_date: 2013-08-13T12:16:26Z [Term] id: GO:0097500 name: receptor localization to non-motile cilium namespace: biological_process def: "A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241] synonym: "receptor localization to nonmotile primary cilium" RELATED [] is_a: GO:0097499 ! protein localization to non-motile cilium is_a: GO:1903441 ! protein localization to ciliary membrane created_by: paola creation_date: 2013-08-13T12:17:34Z [Term] id: GO:0097501 name: stress response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus." [GOC:kmv] synonym: "response to excess metal ion" RELATED [] synonym: "response to metal ion stress" EXACT [] synonym: "response to metal ion toxicity" RELATED [] synonym: "response to metal toxicity" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0010038 ! response to metal ion created_by: paola creation_date: 2013-08-15T10:37:45Z [Term] id: GO:0097502 name: mannosylation namespace: biological_process def: "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm] is_a: GO:0070085 ! glycosylation created_by: paola creation_date: 2013-09-20T09:47:40Z [Term] id: GO:0097503 name: sialylation namespace: biological_process def: "The covalent attachment of sialic acid to a substrate molecule." [GOC:cjm] is_a: GO:0043412 ! macromolecule modification created_by: paola creation_date: 2013-09-20T09:53:10Z [Term] id: GO:0097504 name: Gemini of coiled bodies namespace: cellular_component def: "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, http://en.wikipedia.org/wiki/Cell_nucleus#Cajal_bodies_and_gems, PMID:11031238, PMID:9683623] synonym: "Gems" EXACT [] is_a: GO:0016604 ! nuclear body created_by: paola creation_date: 2013-09-24T15:20:12Z [Term] id: GO:0097505 name: Rad6-Rad18 complex namespace: cellular_component def: "A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity." [GOC:jd, PMID:9287349] is_a: GO:0000151 ! ubiquitin ligase complex created_by: paola creation_date: 2013-09-26T13:42:58Z [Term] id: GO:0097506 name: deaminated base DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated bases." [GOC:al, PMID:18789404] synonym: "deaminated base DNA glycosylase activity" EXACT [] synonym: "DNA glycosylase activity acting on deaminated bases" EXACT [] is_a: GO:0019104 ! DNA N-glycosylase activity created_by: paola creation_date: 2013-09-26T16:00:40Z [Term] id: GO:0097507 name: hypoxanthine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)." [GOC:al, PMID:18789404] synonym: "hypoxanthine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity created_by: paola creation_date: 2013-09-26T16:02:08Z [Term] id: GO:0097508 name: xanthine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated guanine (xanthine)." [GOC:al, PMID:18789404] synonym: "xanthine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity created_by: paola creation_date: 2013-09-26T16:03:10Z [Term] id: GO:0097509 name: oxanine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination." [GOC:al, PMID:18789404] synonym: "oxanine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity created_by: paola creation_date: 2013-09-26T16:03:58Z [Term] id: GO:0097510 name: base-excision repair, AP site formation via deaminated base removal namespace: biological_process def: "A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404] is_a: GO:0006285 ! base-excision repair, AP site formation relationship: has_part GO:0097506 ! deaminated base DNA N-glycosylase activity created_by: paola creation_date: 2013-10-08T14:44:01Z [Term] id: GO:0097511 name: dendritic cell dendrite namespace: cellular_component def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351] is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: paola creation_date: 2013-10-16T13:02:25Z [Term] id: GO:0097512 name: cardiac myofibril namespace: cellular_component def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol] is_a: GO:0030016 ! myofibril created_by: paola creation_date: 2013-10-16T13:04:58Z [Term] id: GO:0097513 name: myosin II filament namespace: cellular_component def: "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah] is_a: GO:0032982 ! myosin filament created_by: paola creation_date: 2013-10-16T13:06:20Z [Term] id: GO:0097514 name: sexual spore wall namespace: cellular_component def: "A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:cjm, GOC:mah] is_a: GO:0031160 ! spore wall created_by: paola creation_date: 2013-10-16T15:10:32Z [Term] id: GO:0097515 name: asexual spore wall namespace: cellular_component def: "A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species." [GOC:cjm, GOC:mah] is_a: GO:0031160 ! spore wall created_by: paola creation_date: 2013-10-16T15:11:21Z [Term] id: GO:0097516 name: microvillar actin bundle namespace: cellular_component def: "A parallel bundle of actin filaments at the core of a microvillus." [GOC:cjm, GOC:mah] is_a: GO:0098859 ! actin filament bundle of actin-based cell projection intersection_of: GO:0097518 ! parallel actin filament bundle intersection_of: part_of GO:0005902 ! microvillus relationship: part_of GO:0005902 ! microvillus created_by: paola creation_date: 2013-10-16T15:12:13Z [Term] id: GO:0097517 name: contractile actin filament bundle namespace: cellular_component def: "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] is_a: GO:0032432 ! actin filament bundle disjoint_from: GO:0097518 ! parallel actin filament bundle created_by: paola creation_date: 2013-10-16T15:41:14Z [Term] id: GO:0097518 name: parallel actin filament bundle namespace: cellular_component def: "An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:cjm, GOC:mah, ISBN:0815316194] is_a: GO:0032432 ! actin filament bundle created_by: paola creation_date: 2013-10-16T15:42:17Z [Term] id: GO:0097519 name: DNA recombinase complex namespace: cellular_component def: "A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA." [GOC:cjm, PMID:10357855] is_a: GO:0032993 ! protein-DNA complex created_by: paola creation_date: 2013-10-16T15:43:22Z [Term] id: GO:0097520 name: nucleotide-excision repair, preincision complex namespace: cellular_component def: "A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage." [GOC:cjm, GOC:elh, PMID:10197977] synonym: "UvrA(2)-UvrB(2) complex" NARROW [PMID:12145219] synonym: "UvrA(2)B(2) complex" NARROW [GOC:bhm, PMID:12145219] synonym: "UvrB dimer" NARROW [GOC:bhm, PMID:12145219] is_a: GO:0032993 ! protein-DNA complex created_by: paola creation_date: 2013-10-17T14:32:37Z [Term] id: GO:0097522 name: protein-DNA ISRE complex namespace: cellular_component def: "A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, GOC:cjm, PMID:11747630] is_a: GO:0032993 ! protein-DNA complex created_by: paola creation_date: 2013-10-17T14:35:07Z [Term] id: GO:0097523 name: transcription ternary complex namespace: cellular_component def: "A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript." [GOC:cjm, GOC:txnOH] synonym: "transcription protein-DNA-RNA complex" EXACT [] is_a: GO:0001114 ! protein-DNA-RNA complex created_by: paola creation_date: 2013-10-18T11:29:57Z [Term] id: GO:0097524 name: sperm plasma membrane namespace: cellular_component def: "A plasma membrane that is part of a sperm cell." [GOC:cjm] is_a: GO:0005886 ! plasma membrane created_by: paola creation_date: 2013-10-18T11:31:17Z [Term] id: GO:0097525 name: spliceosomal snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex involved in formation of the spliceosome and composed of one or more snRNA and multiple protein components." [GOC:pr, ISBN:0879695897] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex created_by: paola creation_date: 2013-10-18T15:57:45Z [Term] id: GO:0097526 name: spliceosomal tri-snRNP complex namespace: cellular_component def: "A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins." [GOC:pr, ISBN:0879695897, PMID:9452384] is_a: GO:0097525 ! spliceosomal snRNP complex created_by: paola creation_date: 2013-10-18T15:58:47Z [Term] id: GO:0097527 name: necroptotic signaling pathway namespace: biological_process def: "A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered." [GOC:mtg_apoptosis, PMID:20823910] comment: Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality. synonym: "necroptosis signaling" RELATED [] synonym: "necroptosis signaling pathway" EXACT [] synonym: "necroptotic signal transduction" EXACT [GOC:signaling] synonym: "necroptotic signalling pathway" RELATED [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0070266 ! necroptotic process created_by: paola creation_date: 2013-11-05T14:17:28Z [Term] id: GO:0097528 name: execution phase of necroptosis namespace: biological_process def: "A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died." [GOC:mtg_apoptosis, PMID:20823910] synonym: "execution phase of necroptotic process" EXACT [] synonym: "necroptosis" BROAD [] synonym: "necroptotic execution phase" EXACT [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0070266 ! necroptotic process created_by: paola creation_date: 2013-11-05T14:23:53Z [Term] id: GO:0097529 name: myeloid leukocyte migration namespace: biological_process def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461] is_a: GO:0050900 ! leukocyte migration created_by: paola creation_date: 2013-11-11T13:59:43Z [Term] id: GO:0097530 name: granulocyte migration namespace: biological_process def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336] is_a: GO:0097529 ! myeloid leukocyte migration created_by: paola creation_date: 2013-11-11T14:00:44Z [Term] id: GO:0097531 name: mast cell migration namespace: biological_process def: "The movement of a mast cell within or between different tissues and organs of the body." [GOC:cvs, PMID:24152847] is_a: GO:0097529 ! myeloid leukocyte migration created_by: paola creation_date: 2013-11-11T14:01:41Z [Term] id: GO:0097532 name: stress response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, http://en.wikipedia.org/wiki/Acid, PMID:10615049, PMID:19170886] synonym: "response to acid stress" BROAD [] synonym: "stress response to acid" BROAD [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0006950 ! response to stress created_by: paola creation_date: 2013-11-12T13:04:15Z [Term] id: GO:0097533 name: cellular stress response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, http://en.wikipedia.org/wiki/Acid, PMID:10615049, PMID:19170886] synonym: "cellular response to acid stress" BROAD [] synonym: "cellular stress response to acid" BROAD [] is_a: GO:0097532 ! stress response to acid chemical relationship: part_of GO:0033554 ! cellular response to stress relationship: part_of GO:0071229 ! cellular response to acid chemical created_by: paola creation_date: 2013-11-12T13:07:12Z [Term] id: GO:0097534 name: lymphoid lineage cell migration namespace: biological_process def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843] synonym: "lymphoid lineage restricted progenitor cell migration" EXACT [] is_a: GO:0016477 ! cell migration created_by: paola creation_date: 2013-11-28T10:47:15Z [Term] id: GO:0097535 name: lymphoid lineage cell migration into thymus namespace: biological_process def: "The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process." [GOC:cvs, PMID:22342843] synonym: "lymphoid lineage restricted progenitor cell migration into thymus" EXACT [] is_a: GO:0097534 ! lymphoid lineage cell migration created_by: paola creation_date: 2013-11-28T10:48:58Z [Term] id: GO:0097536 name: thymus epithelium morphogenesis namespace: biological_process def: "The process in which the thymus epithelium is generated and organized." [GOC:pr, PMID:22342843] synonym: "thymic epithelium morphogenesis" EXACT [] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0048538 ! thymus development created_by: paola creation_date: 2013-11-28T10:51:03Z [Term] id: GO:0097537 name: Y-shaped link namespace: cellular_component def: "A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium." [GOC:cilia, PMID:22653444, PMID:4554367] synonym: "membrane-microtubule complex" RELATED [] synonym: "Y-link" RELATED [] synonym: "Y-link structure" RELATED [] synonym: "Y-shaped assemblage" RELATED [] synonym: "Y-shaped fiber" RELATED [] synonym: "Y-shaped fibre" RELATED [] synonym: "Y-shaped linker" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0035869 ! ciliary transition zone created_by: paola creation_date: 2013-12-03T16:34:34Z [Term] id: GO:0097538 name: ciliary necklace namespace: cellular_component def: "A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links." [GOC:cilia, PMID:22653444, PMID:4554367] synonym: "cilial necklace" EXACT [] synonym: "cilium necklace" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0035869 ! ciliary transition zone relationship: part_of GO:0060170 ! ciliary membrane created_by: paola creation_date: 2013-12-03T16:43:41Z [Term] id: GO:0097539 name: ciliary transition fiber namespace: cellular_component def: "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827] comment: In mammals, ciliary transition fibers comprise at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) (PMID:24469809). synonym: "centriolar distal appendage" RELATED [PMID:24469809] synonym: "cilial transition fiber" EXACT [] synonym: "cilial transition fibre" EXACT [] synonym: "ciliary transition fibre" EXACT [] synonym: "cilium transition fiber" EXACT [] synonym: "cilium transition fibre" EXACT [] synonym: "distal appendage of basal body" RELATED [GOC:krc] synonym: "distal appendage of centriole" RELATED [GOC:krc] synonym: "distal appendage of mother centriole" RELATED [GOC:krc] synonym: "transition fiber" BROAD [] synonym: "transition fibre" BROAD [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2013-12-03T16:46:37Z [Term] id: GO:0097540 name: axonemal central pair namespace: cellular_component def: "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia." [GOC:cilia, GOC:krc, PMID:24283352] synonym: "axonemal microtubule central pair" EXACT [] synonym: "axoneme central pair" EXACT [] synonym: "axoneme microtubule central pair" EXACT [] synonym: "central pair" BROAD [] synonym: "central-pair microtubules" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:1990719 ! C1 axonemal microtubule relationship: has_part GO:1990720 ! C2 axonemal microtubule relationship: part_of GO:1990716 ! axonemal central apparatus created_by: paola creation_date: 2013-12-12T11:07:09Z [Term] id: GO:0097541 name: axonemal basal plate namespace: cellular_component def: "Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure." [GOC:cilia, PMID:23352055, PMID:4554367] synonym: "axoneme basal plate" EXACT [] synonym: "basal plate" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005930 ! axoneme created_by: paola creation_date: 2013-12-12T11:10:39Z [Term] id: GO:0097542 name: ciliary tip namespace: cellular_component def: "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial tip" EXACT [] synonym: "cilium tip" EXACT [] synonym: "flagellar tip" EXACT [] synonym: "flagellum tip" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2013-12-12T11:12:22Z [Term] id: GO:0097543 name: ciliary inversin compartment namespace: cellular_component def: "Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium." [GOC:cilia, PMID:19050042] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial inversin compartment" EXACT [] synonym: "cilium inversin compartment" EXACT [] synonym: "flagellar inversin compartment" EXACT [] synonym: "flagellum inversin compartment" EXACT [] synonym: "Inv compartment of the cilium" EXACT [] synonym: "inversin compartment" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2013-12-12T11:14:36Z [Term] id: GO:0097544 name: ciliary shaft namespace: cellular_component def: "The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space." [GOC:cilia, GOC:krc, PMID:19866682] comment: Note that 'ciliary shaft' is sparingly used in the literature to denote the projecting part of the cilium; many authors would refer to the axoneme instead. However, the definition of GO:0005930 'axoneme' is rather stringent, and the localization of many ciliary proteins would not fit that definition. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial shaft" EXACT [] synonym: "cilium shaft" EXACT [] synonym: "flagellar shaft" EXACT [] synonym: "flagellum shaft" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005930 ! axoneme relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2013-12-12T11:17:30Z [Term] id: GO:0097545 name: axonemal outer doublet namespace: cellular_component def: "Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium." [GOC:cilia, GOC:krc, GOC:pr, http://en.wikipedia.org/wiki/Axoneme, PMID:5044758, PMID:5664206] synonym: "axoneme outer doublet" EXACT [] synonym: "outer doublet" BROAD [] synonym: "outer-doublet microtubules" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097649 ! A axonemal microtubule relationship: has_part GO:0097650 ! B axonemal microtubule relationship: part_of GO:0005930 ! axoneme created_by: paola creation_date: 2013-12-12T11:19:29Z [Term] id: GO:0097546 name: ciliary base namespace: cellular_component def: "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] comment: Due to resolution issues, researchers are often unable to assign protein localization to more specific ciliary compartments such as the basal body, transition fibers or transition zone, and instead refer to 'ciliary base'. The terms GO:0036064 'ciliary basal body', GO:0097539 'ciliary transition fiber' and GO:0035869 'ciliary transition zone' represent strictly defined compartments at the ciliary base and should be used for annotation whenever possible. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial base" EXACT [] synonym: "cilium base" EXACT [] synonym: "flagellar base" EXACT [] synonym: "flagellum base" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0035869 ! ciliary transition zone relationship: has_part GO:0097539 ! ciliary transition fiber relationship: part_of GO:0005929 ! cilium created_by: paola creation_date: 2013-12-17T14:16:04Z [Term] id: GO:0097547 name: synaptic vesicle protein transport vesicle namespace: cellular_component def: "A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270] comment: This term should not be confused with GO:0008021 'synaptic vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. synonym: "STV" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle created_by: paola creation_date: 2013-12-20T09:22:03Z [Term] id: GO:0097548 name: seed abscission namespace: biological_process def: "The controlled shedding of a seed." [GOC:lmo] is_a: GO:0009838 ! abscission created_by: paola creation_date: 2014-01-22T07:57:41Z [Term] id: GO:0097549 name: chromatin organization involved in negative regulation of transcription namespace: biological_process alt_id: GO:1903758 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093] subset: gocheck_do_not_manually_annotate synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription by chromatin organization" EXACT [] synonym: "negative regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] is_a: GO:0034401 ! chromatin organization involved in regulation of transcription intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0045892 ! negative regulation of transcription, DNA-templated relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated created_by: paola creation_date: 2014-01-22T08:20:50Z [Term] id: GO:0097550 name: transcriptional preinitiation complex namespace: cellular_component def: "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016] synonym: "DNA-templated transcriptional preinitiation complex" EXACT [] synonym: "PIC" NARROW [] synonym: "preinitiation complex" NARROW [] synonym: "transcription preinitiation complex" EXACT [] synonym: "transcriptional pre-initiation complex" EXACT [] is_a: GO:0032993 ! protein-DNA complex created_by: paola creation_date: 2014-01-22T09:33:44Z [Term] id: GO:0097551 name: mitochondrial double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:di, PMID:22214610] comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. synonym: "mtDSB repair" EXACT [] is_a: GO:0006302 ! double-strand break repair created_by: paola creation_date: 2014-01-22T10:06:54Z [Term] id: GO:0097552 name: mitochondrial double-strand break repair via homologous recombination namespace: biological_process def: "The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610] comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. synonym: "mtDSB repair via homologous recombination" EXACT [] is_a: GO:0000725 ! recombinational repair is_a: GO:0097551 ! mitochondrial double-strand break repair created_by: paola creation_date: 2014-01-22T10:09:10Z [Term] id: GO:0097553 name: calcium ion transmembrane import into cytosol namespace: biological_process def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw] synonym: "calcium transmembrane import into cytosol" BROAD [] is_a: GO:0060402 ! calcium ion transport into cytosol is_a: GO:0070588 ! calcium ion transmembrane transport created_by: paola creation_date: 2014-01-23T11:05:13Z [Term] id: GO:0097554 name: left anterior flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "left anterior cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T12:47:41Z [Term] id: GO:0097555 name: right anterior flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "right anterior cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:18:36Z [Term] id: GO:0097556 name: left posteriolateral flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "left posteriolateral cilium" EXACT [] synonym: "left posterolateral cilium" EXACT [] synonym: "left posterolateral flagellum" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:21:09Z [Term] id: GO:0097557 name: right posteriolateral flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "right posteriolateral cilium" EXACT [] synonym: "right posterolateral cilium" EXACT [] synonym: "right posterolateral flagellum" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:24:55Z [Term] id: GO:0097558 name: left ventral flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "left ventral cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:26:51Z [Term] id: GO:0097559 name: right ventral flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "right ventral cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:28:20Z [Term] id: GO:0097560 name: left caudal flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "left caudal cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:29:44Z [Term] id: GO:0097561 name: right caudal flagellum namespace: cellular_component def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "right caudal cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-02-05T13:31:15Z [Term] id: GO:0097562 name: left lateral basal body pair namespace: cellular_component def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:1902671 ! left anterior basal body relationship: has_part GO:1902675 ! left ventral basal body relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:09:11Z [Term] id: GO:0097563 name: left middle basal body pair namespace: cellular_component def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:1902673 ! left posteriolateral basal body relationship: has_part GO:1902677 ! left caudal basal body relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:11:14Z [Term] id: GO:0097564 name: right lateral basal body pair namespace: cellular_component def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:1902672 ! right anterior basal body relationship: has_part GO:1902676 ! right ventral basal body relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:12:42Z [Term] id: GO:0097565 name: right middle basal body pair namespace: cellular_component def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:1902674 ! right posteriolateral basal body relationship: has_part GO:1902678 ! right caudal basal body relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:14:05Z [Term] id: GO:0097566 name: left tetrad namespace: cellular_component def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097562 ! left lateral basal body pair relationship: has_part GO:0097563 ! left middle basal body pair relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:30:43Z [Term] id: GO:0097567 name: right tetrad namespace: cellular_component def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097564 ! right lateral basal body pair relationship: has_part GO:0097565 ! right middle basal body pair relationship: part_of GO:0042995 ! cell projection created_by: paola creation_date: 2014-02-05T16:32:33Z [Term] id: GO:0097568 name: median body namespace: cellular_component def: "A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc." [GOC:giardia, PMID:5961344] comment: Note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "parabasal body" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005874 ! microtubule relationship: part_of GO:0005856 ! cytoskeleton created_by: paola creation_date: 2014-02-11T13:34:19Z [Term] id: GO:0097569 name: lateral shield namespace: cellular_component def: "Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella." [GOC:giardia, ISBN:9780124260207] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044297 ! cell body created_by: paola creation_date: 2014-02-11T13:37:10Z [Term] id: GO:0097570 name: cyst wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, PMID:15134259, PMID:2026212] is_a: GO:0005618 ! cell wall created_by: paola creation_date: 2014-02-18T10:25:53Z [Term] id: GO:0097571 name: left nucleus namespace: cellular_component def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0005634 ! nucleus created_by: paola creation_date: 2014-02-18T11:21:31Z [Term] id: GO:0097572 name: right nucleus namespace: cellular_component def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. is_a: GO:0005634 ! nucleus created_by: paola creation_date: 2014-02-18T11:23:01Z [Term] id: GO:0097573 name: glutathione oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione." [GOC:jd, PMID:18992757] comment: Note that this activity is different from GO:0015038 'glutathione disulfide oxidoreductase activity'. See PMID:18992757: "Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism". is_a: GO:0015035 ! protein disulfide oxidoreductase activity created_by: paola creation_date: 2014-02-19T13:41:38Z [Term] id: GO:0097574 name: lateral part of cell namespace: cellular_component def: "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells." [GOC:pr] is_a: GO:0110165 ! cellular anatomical entity created_by: paola creation_date: 2014-02-26T13:27:27Z [Term] id: GO:0097575 name: lateral cell cortex namespace: cellular_component def: "The region directly beneath the plasma membrane of the lateral portion of the cell." [GOC:mah, PMID:24146635] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0097574 ! lateral part of cell relationship: part_of GO:0097574 ! lateral part of cell created_by: paola creation_date: 2014-02-26T13:29:22Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, http://en.wikipedia.org/wiki/Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion created_by: paola creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097577 name: sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] synonym: "iron ion retention" EXACT [] synonym: "iron ion sequestering" EXACT [] synonym: "iron ion sequestration" EXACT [] synonym: "iron ion storage" EXACT [] synonym: "retention of iron ion" EXACT [] synonym: "sequestration of iron ion" EXACT [] synonym: "storage of iron ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0006879 ! cellular iron ion homeostasis created_by: paola creation_date: 2014-02-28T11:10:53Z [Term] id: GO:0097578 name: sequestering of copper ion namespace: biological_process def: "The process of binding or confining copper ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] synonym: "copper ion retention" EXACT [] synonym: "copper ion sequestering" EXACT [] synonym: "copper ion sequestration" EXACT [] synonym: "copper ion storage" EXACT [] synonym: "retention of copper ion" EXACT [] synonym: "sequestration of copper ion" EXACT [] synonym: "storage of copper ion" EXACT [] is_a: GO:0006878 ! cellular copper ion homeostasis is_a: GO:0051238 ! sequestering of metal ion created_by: paola creation_date: 2014-02-28T11:15:02Z [Term] id: GO:0097579 name: extracellular sequestering of copper ion namespace: biological_process def: "The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] synonym: "extracellular copper ion retention" EXACT [] synonym: "extracellular copper ion sequestering" EXACT [] synonym: "extracellular copper ion sequestration" EXACT [] synonym: "extracellular copper ion storage" EXACT [] synonym: "extracellular retention of copper ion" EXACT [] synonym: "extracellular sequestration of copper ion" EXACT [] synonym: "extracellular storage of copper ion" EXACT [] is_a: GO:0097578 ! sequestering of copper ion intersection_of: GO:0097578 ! sequestering of copper ion intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region relationship: part_of GO:0006878 ! cellular copper ion homeostasis created_by: paola creation_date: 2014-02-28T11:18:04Z [Term] id: GO:0097580 name: intracellular sequestering of copper ion namespace: biological_process def: "The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] synonym: "intracellular copper ion retention" EXACT [] synonym: "intracellular copper ion sequestering" EXACT [] synonym: "intracellular copper ion sequestration" EXACT [] synonym: "intracellular copper ion storage" EXACT [] synonym: "intracellular retention of copper ion" EXACT [] synonym: "intracellular sequestration of copper ion" EXACT [] synonym: "intracellular storage of copper ion" EXACT [] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0097578 ! sequestering of copper ion intersection_of: GO:0097578 ! sequestering of copper ion intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular relationship: part_of GO:0006878 ! cellular copper ion homeostasis created_by: paola creation_date: 2014-02-28T11:21:39Z [Term] id: GO:0097581 name: lamellipodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [GOC:als, PMID:16054028] is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: paola creation_date: 2014-02-28T16:08:56Z [Term] id: GO:0097582 name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex namespace: cellular_component def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p." [GOC:jd, PMID:12551906] synonym: "Pmt1p-Pmt2p complex" NARROW [] is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex created_by: paola creation_date: 2014-03-02T18:13:34Z [Term] id: GO:0097583 name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex namespace: cellular_component def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p." [GOC:jd, PMID:12551906] synonym: "Pmt1p-Pmt3p complex" NARROW [] is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex created_by: paola creation_date: 2014-03-02T18:16:29Z [Term] id: GO:0097584 name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex namespace: cellular_component def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p." [GOC:jd, PMID:12551906] synonym: "Pmt5p-Pmt2p complex" NARROW [] is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex created_by: paola creation_date: 2014-03-02T18:17:22Z [Term] id: GO:0097585 name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex namespace: cellular_component def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p." [GOC:jd, PMID:12551906] synonym: "Pmt5p-Pmt3p complex" NARROW [] is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex created_by: paola creation_date: 2014-03-02T18:18:28Z [Term] id: GO:0097586 name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex namespace: cellular_component def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p." [GOC:bhm, GOC:jd, PMID:12551906] synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer" EXACT [] synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex" EXACT [] synonym: "Pmt4p-Pmt4p complex" NARROW [] is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex created_by: paola creation_date: 2014-03-02T18:19:05Z [Term] id: GO:0097587 name: MutLgamma complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3." [GOC:jd, PMID:10570173] is_a: GO:0032300 ! mismatch repair complex created_by: paola creation_date: 2014-03-06T11:48:12Z [Term] id: GO:0097588 name: archaeal or bacterial-type flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of bacterial- or archaeal-type flagella." [GOC:cilia, GOC:krc] comment: Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. This term was added for mapping to the UniProt keyword "flagellar rotation". For manual annotation, please use one of the child terms of GO:0097588 that refer specifically to either archaeal- or bacterial-type flagella. is_a: GO:0001539 ! cilium or flagellum-dependent cell motility created_by: paola creation_date: 2014-03-25T16:51:19Z [Term] id: GO:0097589 name: archaeal-type flagellum namespace: cellular_component def: "A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function." [GOC:cilia, GOC:krc, http://en.wikipedia.org/wiki/Flagellum#Archaeal, PMID:21265748, PMID:23146836, PMID:23204365, PMID:24330313] synonym: "archaeal flagellum" RELATED [] synonym: "archaella" RELATED [] synonym: "archaellum" EXACT [] is_a: GO:0042995 ! cell projection is_a: GO:0043228 ! non-membrane-bounded organelle created_by: paola creation_date: 2014-03-25T20:36:24Z [Term] id: GO:0097590 name: archaeal-type flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel." [GOC:cilia, GOC:krc, http://en.wikipedia.org/wiki/Flagellum#Archaeal] synonym: "archaeal-type flagellar cell motility" RELATED [] is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility created_by: paola creation_date: 2014-03-25T20:40:50Z [Term] id: GO:0097591 name: ventral disc lateral crest namespace: cellular_component def: "Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet." [GOC:giardia] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "lateral crest" BROAD [] synonym: "ventral disk lateral crest" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T10:47:48Z [Term] id: GO:0097592 name: ventral disc overlap zone namespace: cellular_component def: "A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself)." [GOC:giardia] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "overlap zone" BROAD [] synonym: "ventral disk overlap zone" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097593 ! ventral disc microtubule array relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T11:12:50Z [Term] id: GO:0097593 name: ventral disc microtubule array namespace: cellular_component def: "A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane." [GOC:giardia] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "spiral microtubule array" BROAD [] synonym: "ventral disc spiral microtubule array" EXACT [] synonym: "ventral disk microtubule array" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005874 ! microtubule relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T11:17:17Z [Term] id: GO:0097594 name: ventral disc dorsal microribbon namespace: cellular_component def: "Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons." [GOC:giardia, PMID:11432808] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "dorsal microribbon" BROAD [] synonym: "dorsal ribbon" BROAD [] synonym: "microribbon" BROAD [] synonym: "ventral disk dorsal microribbon" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T11:20:06Z [Term] id: GO:0097595 name: ventral disc crossbridge namespace: cellular_component def: "Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet." [GOC:giardia] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "crossbridge" BROAD [] synonym: "ventral disk crossbridge" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T11:23:33Z [Term] id: GO:0097596 name: ventral disc supernumerary microtubule array namespace: cellular_component def: "A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage)." [GOC:giardia, ISBN:9780124260207] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "supernumerary microtubule array" BROAD [] synonym: "ventral disk supernumerary microtubule array" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005874 ! microtubule relationship: part_of GO:0097597 ! ventral disc created_by: paola creation_date: 2014-04-03T11:25:07Z [Term] id: GO:0097597 name: ventral disc namespace: cellular_component def: "Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence." [GOC:giardia, ISBN:9780124260207, PMID:11432808, PMID:4777416, PMID:5961344] comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "adhesive disc" RELATED [] synonym: "ventral adhesive disc" EXACT [] synonym: "ventral disk" RELATED [] is_a: GO:0043226 ! organelle relationship: has_part GO:0097591 ! ventral disc lateral crest relationship: has_part GO:0097592 ! ventral disc overlap zone relationship: has_part GO:0097594 ! ventral disc dorsal microribbon relationship: has_part GO:0097595 ! ventral disc crossbridge created_by: paola creation_date: 2014-04-03T11:29:58Z [Term] id: GO:0097598 name: sperm cytoplasmic droplet namespace: cellular_component def: "A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce \"residual bodies\". Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from \"excessive residual cytoplasm\" that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted." [GOC:krc, GOC:vesicles, PMID:12672117, PMID:21076437, PMID:23159014] synonym: "sperm residual cytoplasm" EXACT [] is_a: GO:0097708 ! intracellular vesicle created_by: paola creation_date: 2014-04-10T14:03:30Z [Term] id: GO:0097599 name: xylanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues." [GOC:jh2, ISBN:81-7736-269-0] synonym: "xylosidase activity" RELATED [] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds created_by: paola creation_date: 2014-05-06T13:46:48Z [Term] id: GO:0097600 name: exoxylanase activity namespace: molecular_function def: "A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains." [GOC:jh2, ISBN:81-7736-269-0, PMID:16535010] is_a: GO:0097599 ! xylanase activity created_by: paola creation_date: 2014-05-06T13:48:27Z [Term] id: GO:0097601 name: retina blood vessel maintenance namespace: biological_process def: "A retina homeostatic process preventing the degeneration of a retina blood vessel." [GOC:jh2, PMID:23093773] synonym: "maintenance of choriocapillaris" NARROW [] synonym: "maintenance of retina blood vessel" EXACT [] synonym: "maintenance of retinal blood vessel" EXACT [] is_a: GO:0001895 ! retina homeostasis created_by: paola creation_date: 2014-05-11T18:42:24Z [Term] id: GO:0097602 name: cullin family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375] synonym: "cullin binding" NARROW [] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2014-05-11T20:41:10Z [Term] id: GO:0097603 name: temperature-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824] synonym: "heat-activated ion channel activity" NARROW [] synonym: "temperature gated ion channel activity" EXACT [] synonym: "temperature-activated ion channel activity" EXACT [] synonym: "temperature-dependent ion channel activity" EXACT [] is_a: GO:0005216 ! ion channel activity is_a: GO:0022836 ! gated channel activity created_by: paola creation_date: 2014-05-12T13:10:42Z [Term] id: GO:0097604 name: temperature-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824] synonym: "heat-activated cation channel activity" NARROW [] synonym: "temperature gated cation channel activity" EXACT [] synonym: "temperature-activated cation channel activity" EXACT [] synonym: "temperature-dependent cation channel activity" EXACT [] is_a: GO:0005261 ! cation channel activity is_a: GO:0097603 ! temperature-gated ion channel activity created_by: paola creation_date: 2014-05-12T13:13:46Z [Term] id: GO:0097605 name: obsolete regulation of nuclear envelope permeability namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. synonym: "regulation of nuclear membrane permeability" RELATED [] is_obsolete: true created_by: paola creation_date: 2014-05-14T15:41:44Z [Term] id: GO:0097606 name: obsolete positive regulation of nuclear envelope permeability namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. synonym: "positive regulation of nuclear membrane permeability" RELATED [] is_obsolete: true created_by: paola creation_date: 2014-05-14T15:43:06Z [Term] id: GO:0097607 name: obsolete negative regulation of nuclear envelope permeability namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. synonym: "negative regulation of nuclear membrane permeability" RELATED [] is_obsolete: true created_by: paola creation_date: 2014-05-14T15:43:47Z [Term] id: GO:0097608 name: transverse flagellum namespace: cellular_component def: "A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. synonym: "transverse cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-06-09T11:14:37Z [Term] id: GO:0097609 name: longitudinal flagellum namespace: cellular_component def: "A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. synonym: "longitudinal cilium" EXACT [] is_a: GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2014-06-09T11:21:10Z [Term] id: GO:0097610 name: cell surface furrow namespace: cellular_component def: "A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates." [GOC:pr] synonym: "cell surface groove" RELATED [] synonym: "furrow" BROAD [] synonym: "groove" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009986 ! cell surface created_by: paola creation_date: 2014-06-09T11:22:38Z [Term] id: GO:0097611 name: dinoflagellate cingulum namespace: cellular_component def: "A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "cingulum" BROAD [] synonym: "girdle" RELATED [] synonym: "transverse groove" RELATED [] is_a: GO:0097610 ! cell surface furrow created_by: paola creation_date: 2014-06-09T11:28:22Z [Term] id: GO:0097612 name: dinoflagellate sulcus namespace: cellular_component def: "A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). synonym: "longitudinal furrow" RELATED [] synonym: "longitudinal groove" RELATED [] synonym: "sulcus" BROAD [] is_a: GO:0097610 ! cell surface furrow created_by: paola creation_date: 2014-06-09T11:31:05Z [Term] id: GO:0097613 name: dinoflagellate epicone namespace: cellular_component def: "The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "epicone" BROAD [] synonym: "episome" RELATED [] synonym: "epitheca" RELATED [] is_a: GO:0110165 ! cellular anatomical entity created_by: paola creation_date: 2014-06-09T11:32:48Z [Term] id: GO:0097614 name: dinoflagellate hypocone namespace: cellular_component def: "The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "hypocone" BROAD [] synonym: "hyposome" RELATED [] synonym: "hypotheca" RELATED [] is_a: GO:0110165 ! cellular anatomical entity created_by: paola creation_date: 2014-06-09T11:35:07Z [Term] id: GO:0097615 name: modulation by host of symbiont type IV pilus-dependent motility namespace: biological_process def: "The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568] synonym: "modulation by host of bacterial type IV pilus-dependent motility" EXACT [] is_a: GO:0051851 ! modification by host of symbiont morphology or physiology created_by: paola creation_date: 2014-06-10T13:17:13Z [Term] id: GO:0097616 name: positive regulation by host of symbiont type IV pilus-dependent motility namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568] synonym: "positive regulation by host of bacterial type IV pilus-dependent motility" EXACT [] is_a: GO:0097615 ! modulation by host of symbiont type IV pilus-dependent motility created_by: paola creation_date: 2014-06-10T13:19:51Z [Term] id: GO:0097617 name: annealing activity namespace: molecular_function def: "A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide." [GOC:mba, http://en.wikipedia.org/wiki/Nucleic_acid_thermodynamics#Annealing] comment: The term 'annealing' is often used to describe the binding of a DNA probe, or the binding of a primer to a DNA strand during a polymerase chain reaction. The term is also often used to describe the reformation (renaturation) of complementary strands that were separated by heat (thermally denatured). For example, proteins such as RAD52 can help DNA anneal. If at all possible, please annotate to the more specific terms GO:0036310 'annealing helicase activity', GO:0097098 'DNA/RNA hybrid annealing activity' or GO:0033592 'RNA strand annealing activity'. synonym: "renaturation" RELATED [] xref: Reactome:R-HSA-5686642 "RAD52 promotes single strand annealing at resected DNA DSBs" is_a: GO:0003676 ! nucleic acid binding created_by: paola creation_date: 2014-06-13T10:18:43Z [Term] id: GO:0097618 name: dinoflagellate sulcal notch namespace: cellular_component def: "A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). The term 'sulcal notch' appears mostly in older literature; more recently, indication of a bilobed hypocone is used to express the same. synonym: "dinoflagellate sulcus notch" EXACT [] synonym: "sulcal notch" RELATED [] is_a: GO:0097612 ! dinoflagellate sulcus created_by: paola creation_date: 2014-06-27T16:28:49Z [Term] id: GO:0097619 name: PTEX complex namespace: cellular_component def: "A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components." [GOC:pr, PMID:19536257, PMID:25043010, PMID:25043043] synonym: "Plasmodium translocon of exported proteins" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane created_by: paola creation_date: 2014-07-29T16:05:32Z [Term] id: GO:0097620 name: (R)-mandelate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor." [GOC:pr, PMID:1731758, RHEA:43112] comment: In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate. synonym: "D-mandelate dehydrogenase activity" EXACT [] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: paola creation_date: 2014-07-30T09:53:23Z [Term] id: GO:0097621 name: monoamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2." [EC:1.4.3.4, GOC:pr, RHEA:26414] comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. synonym: "amine:oxygen oxidoreductase (deaminating) activity" EXACT [] is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor created_by: paola creation_date: 2014-07-30T10:23:57Z [Term] id: GO:0097622 name: cytoplasmic translational elongation through polyproline stretches namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm." [GOC:mcc, PMID:24923804] is_a: GO:0002182 ! cytoplasmic translational elongation created_by: paola creation_date: 2014-08-06T16:29:10Z [Term] id: GO:0097623 name: potassium ion export across plasma membrane namespace: biological_process alt_id: GO:0071435 alt_id: GO:0098668 def: "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:11932440] comment: Merged as of ticket of related term https://github.com/geneontology/go-ontology/issues/14265 synonym: "potassium export" BROAD [GOC:mah] synonym: "potassium export across plasma membrane" EXACT [] synonym: "potassium ion export" BROAD [] synonym: "potassium ion export from cell" EXACT [] is_a: GO:0071805 ! potassium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: paola creation_date: 2009-12-16T11:10:45Z [Term] id: GO:0097624 name: UDP-galactose transmembrane import into Golgi lumen namespace: biological_process def: "The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane." [GOC:vw, PMID:11378902] synonym: "UDP-galactose import into Golgi lumen" BROAD [] is_a: GO:0072334 ! UDP-galactose transmembrane transport created_by: paola creation_date: 2014-08-18T14:59:23Z [Term] id: GO:0097625 name: low-affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:pr] synonym: "low affinity basic amino acid transmembrane transporter activity" EXACT [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity created_by: paola creation_date: 2014-08-20T14:23:18Z [Term] id: GO:0097626 name: low-affinity L-arginine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:krc, PMID:8195186] synonym: "low affinity L-arginine transmembrane transporter activity" EXACT [] is_a: GO:0061459 ! L-arginine transmembrane transporter activity is_a: GO:0097625 ! low-affinity basic amino acid transmembrane transporter activity created_by: paola creation_date: 2014-08-20T14:24:22Z [Term] id: GO:0097627 name: high-affinity L-ornithine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:krc, PMID:8195186] synonym: "high affinity L-ornithine transmembrane transporter activity" EXACT [] is_a: GO:0000064 ! L-ornithine transmembrane transporter activity created_by: paola creation_date: 2014-08-20T14:26:33Z [Term] id: GO:0097628 name: distal tip cell migration namespace: biological_process def: "The orderly movement of a distal tip cell." [CL:0000661, GOC:mm2, PMID:24968003] is_a: GO:0016477 ! cell migration created_by: paola creation_date: 2014-08-20T16:06:53Z [Term] id: GO:0097629 name: extrinsic component of omegasome membrane namespace: cellular_component def: "The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf, PMID:18725538, PMID:24591649] synonym: "extrinsic to omegasome membrane" EXACT [] synonym: "omegasome peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:1903349 ! omegasome membrane relationship: part_of GO:1903349 ! omegasome membrane [Term] id: GO:0097630 name: intrinsic component of omegasome membrane namespace: cellular_component def: "The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf, PMID:18725538, PMID:24591649] synonym: "intrinsic to omegasome membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:1903349 ! omegasome membrane relationship: part_of GO:1903349 ! omegasome membrane [Term] id: GO:0097631 name: integral component of omegasome membrane namespace: cellular_component def: "The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf, PMID:18725538, PMID:24591649] synonym: "integral to omegasome membrane" NARROW [] synonym: "omegasome integral membrane protein" RELATED [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0097630 ! intrinsic component of omegasome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:1903349 ! omegasome membrane [Term] id: GO:0097632 name: extrinsic component of phagophore assembly site membrane namespace: cellular_component def: "The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf] synonym: "extrinsic component of pre-autophagosomal structure membrane" NARROW [] synonym: "extrinsic to phagophore assembly site membrane" EXACT [] synonym: "phagophore assembly site peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0034045 ! phagophore assembly site membrane relationship: part_of GO:0034045 ! phagophore assembly site membrane [Term] id: GO:0097633 name: intrinsic component of phagophore assembly site membrane namespace: cellular_component def: "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf] synonym: "intrinsic to phagophore assembly site membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0034045 ! phagophore assembly site membrane relationship: part_of GO:0034045 ! phagophore assembly site membrane [Term] id: GO:0097634 name: integral component of phagophore assembly site membrane namespace: cellular_component def: "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf] synonym: "integral to phagophore assembly site membrane" NARROW [] synonym: "phagophore assembly site integral membrane protein" RELATED [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0097633 ! intrinsic component of phagophore assembly site membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0034045 ! phagophore assembly site membrane [Term] id: GO:0097635 name: extrinsic component of autophagosome membrane namespace: cellular_component def: "The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] synonym: "autophagic vacuole peripheral membrane" RELATED [] synonym: "extrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy] synonym: "extrinsic to autophagic vacuole membrane" EXACT [] is_a: GO:0000306 ! extrinsic component of vacuolar membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0000421 ! autophagosome membrane relationship: part_of GO:0000421 ! autophagosome membrane [Term] id: GO:0097636 name: intrinsic component of autophagosome membrane namespace: cellular_component def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:autophagy, GOC:mf] synonym: "intrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy] synonym: "intrinsic to autophagic vacuole membrane" NARROW [] is_a: GO:0031310 ! intrinsic component of vacuolar membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0000421 ! autophagosome membrane relationship: part_of GO:0000421 ! autophagosome membrane [Term] id: GO:0097637 name: integral component of autophagosome membrane namespace: cellular_component def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:autophagy, GOC:mf] synonym: "autophagic vacuole integral membrane protein" RELATED [] synonym: "integral component of autophagic vacuole membrane" EXACT [GOC:autophagy] synonym: "integral to autophagic vacuole membrane" NARROW [] is_a: GO:0031166 ! integral component of vacuolar membrane is_a: GO:0097636 ! intrinsic component of autophagosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0000421 ! autophagosome membrane [Term] id: GO:0097638 name: L-arginine import across plasma membrane namespace: biological_process alt_id: GO:0090467 alt_id: GO:1902765 def: "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "arginine import" BROAD [] synonym: "L-arginine import into cell" EXACT [] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1903400 ! L-arginine transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:0097639 name: L-lysine import across plasma membrane namespace: biological_process alt_id: GO:1903410 def: "The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "L-lysine import into cell" EXACT [] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1903401 ! L-lysine transmembrane transport created_by: pr creation_date: 2014-09-03T09:32:57Z [Term] id: GO:0097640 name: L-ornithine import across plasma membrane namespace: biological_process alt_id: GO:1903411 def: "The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "L-ornithine import into cell" EXACT [] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1903352 ! L-ornithine transmembrane transport created_by: pr creation_date: 2014-09-03T09:48:14Z [Term] id: GO:0097641 name: alpha-ketoglutarate-dependent xanthine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate." [GOC:vw, PMID:15948966, PMID:17429948, RHEA:43120] synonym: "2-oxoglutarate-dependent xanthine dioxygenase activity" EXACT [] synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity" RELATED [] synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity" RELATED [] is_a: GO:0051213 ! dioxygenase activity created_by: paola creation_date: 2014-09-03T14:55:42Z [Term] id: GO:0097642 name: calcitonin family receptor activity namespace: molecular_function def: "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity." [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0008528 ! G protein-coupled peptide receptor activity created_by: paola creation_date: 2014-09-08T15:32:19Z [Term] id: GO:0097643 name: amylin receptor activity namespace: molecular_function def: "Combining with amylin to initiate a change in cell activity." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0097642 ! calcitonin family receptor activity created_by: paola creation_date: 2014-09-08T15:34:16Z [Term] id: GO:0097644 name: calcitonin family binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))." [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0017046 ! peptide hormone binding created_by: paola creation_date: 2014-09-08T20:50:52Z [Term] id: GO:0097645 name: amylin binding namespace: molecular_function def: "Interacting selectively and non-covalently with amylin." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0097644 ! calcitonin family binding created_by: paola creation_date: 2014-09-08T20:53:03Z [Term] id: GO:0097646 name: calcitonin family receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) combining with a calcitonin family receptor on the surface of the target cell. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] synonym: "calcitonin family receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway created_by: paola creation_date: 2014-09-09T17:48:05Z [Term] id: GO:0097647 name: amylin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] synonym: "amilyn receptor signalling pathway" EXACT [] is_a: GO:0097646 ! calcitonin family receptor signaling pathway created_by: paola creation_date: 2014-09-09T17:49:52Z [Term] id: GO:0097648 name: G protein-coupled receptor complex namespace: cellular_component def: "A protein complex that contains G protein-coupled receptors." [GOC:bhm] synonym: "G-protein coupled receptor complex" EXACT [] is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: paola creation_date: 2014-09-10T09:14:30Z [Term] id: GO:0097649 name: A axonemal microtubule namespace: cellular_component def: "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule." [GOC:cilia, ISBN:0716731363] synonym: "A tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: part_of GO:0097545 ! axonemal outer doublet created_by: paola creation_date: 2014-09-10T20:41:28Z [Term] id: GO:0097650 name: B axonemal microtubule namespace: cellular_component def: "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet." [GOC:cilia, ISBN:0716731363] synonym: "B tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: part_of GO:0097545 ! axonemal outer doublet created_by: paola creation_date: 2014-09-10T20:43:18Z [Term] id: GO:0097651 name: phosphatidylinositol 3-kinase complex, class I namespace: cellular_component def: "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488] synonym: "class I phosphatidylinositol 3-kinase complex" EXACT [] synonym: "class I PI3K complex" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex created_by: paola creation_date: 2014-09-16T11:19:58Z [Term] id: GO:0097652 name: phosphatidylinositol 3-kinase complex, class II namespace: cellular_component def: "A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488] synonym: "class II phosphatidylinositol 3-kinase complex" EXACT [] synonym: "class II PI3K complex" EXACT [] is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex created_by: paola creation_date: 2014-09-16T13:14:17Z [Term] id: GO:0097653 name: unencapsulated part of cell namespace: cellular_component def: "The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures." [GOC:curators] synonym: "non-encapsulated part of cell" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005622 ! intracellular relationship: has_part GO:0005886 ! plasma membrane created_by: paola creation_date: 2014-09-23T12:57:14Z [Term] id: GO:0097654 name: platelet SNARE complex namespace: cellular_component def: "A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4." [GOC:bhm, PMID:12130530, PMID:19450911] is_a: GO:0031201 ! SNARE complex created_by: paola creation_date: 2014-09-24T13:50:49Z [Term] id: GO:0097655 name: serpin family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors." [GOC:mr, InterPro:IPR000215, PMID:16737556] synonym: "SERPIN family protein binding" EXACT [] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2014-09-24T16:19:31Z [Term] id: GO:0097656 name: cell-cell self recognition namespace: biological_process def: "A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development." [GOC:pf, PMID:21700835, PMID:23910661] comment: Examples are the membrane proteins TgrB1 and TgrC1 in the social amoeba Dictyostelium discoideum. synonym: "kin discrimination" RELATED [] synonym: "kin recognition" BROAD [] synonym: "self recognition" BROAD [] is_a: GO:0009988 ! cell-cell recognition created_by: paola creation_date: 2014-09-24T20:58:35Z [Term] id: GO:0097657 name: 3',5'-nucleotide bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3',5'-nucleotide bisphosphate + H20 = 5'-nucleotide monophosphate + phosphate." [GOC:jh2, PMID:24401123, RHEA:43532] is_a: GO:0016791 ! phosphatase activity created_by: paola creation_date: 2014-09-25T11:21:39Z [Term] id: GO:0097658 name: Asi complex namespace: cellular_component def: "A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p." [GOC:mcc, PMID:25236469] is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005637 ! nuclear inner membrane created_by: paola creation_date: 2014-09-29T15:08:29Z [Term] id: GO:0097659 name: nucleic acid-templated transcription namespace: biological_process def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_mouse is_a: GO:0032774 ! RNA biosynthetic process created_by: paola creation_date: 2014-10-01T13:49:27Z [Term] id: GO:0097660 name: SCF-Cdc4 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:9346238] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:23:13Z [Term] id: GO:0097661 name: SCF-Ctf13 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:25:56Z [Term] id: GO:0097662 name: SCF-Das1 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:26:27Z [Term] id: GO:0097663 name: SCF-Dia2/Pof3 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:26:44Z [Term] id: GO:0097664 name: SCF-Grr1/Pof2 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe)." [GOC:jd, GOC:vw, PMID:10213692, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:27:10Z [Term] id: GO:0097665 name: SCF-Mdm30 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:27:30Z [Term] id: GO:0097666 name: SCF-Met30/Pof1 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe)." [GOC:jd, GOC:vw, PMID:15147268, PMID:9499404] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:27:49Z [Term] id: GO:0097667 name: SCF-Rcy1/Pof6 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:28:09Z [Term] id: GO:0097668 name: SCF-Saf1/Pof9 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe)." [GOC:jd, GOC:vw, PMID:11283612, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:28:30Z [Term] id: GO:0097669 name: SCF-Skp2 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:28:52Z [Term] id: GO:0097670 name: SCF-Ufo1/Pof10 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:29:13Z [Term] id: GO:0097671 name: SCF-YDR131C ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:29:35Z [Term] id: GO:0097672 name: SCF-Pof5 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] synonym: "SCF-YDR306C ubiquitin ligase complex" RELATED [] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:30:10Z [Term] id: GO:0097673 name: SCF-Ucc1 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994, PMID:25982115] synonym: "SCF-YLR224W ubiquitin ligase complex" EXACT [PMID:14747994] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:30:31Z [Term] id: GO:0097674 name: SCF-YLR352W ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:19882662] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:30:54Z [Term] id: GO:0097675 name: SCF-Hrt3/Pof7 ubiquitin ligase complex namespace: cellular_component def: "An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] is_a: GO:0019005 ! SCF ubiquitin ligase complex created_by: paola creation_date: 2014-10-06T10:31:14Z [Term] id: GO:0097676 name: histone H3-K36 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone." [GOC:lb, PMID:21187428] is_a: GO:0010452 ! histone H3-K36 methylation is_a: GO:0018027 ! peptidyl-lysine dimethylation created_by: paola creation_date: 2014-11-04T10:38:05Z [Term] id: GO:0097677 name: STAT family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses." [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978] synonym: "signal transducers and activators of transcription family protein binding" EXACT [] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2014-11-04T11:31:03Z [Term] id: GO:0097678 name: SOCS family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions." [GOC:mr, InterPro:IPR028413, PMID:23885323, PMID:24705897] synonym: "suppressor of cytokine signaling family protein binding" EXACT [] is_a: GO:0005515 ! protein binding created_by: paola creation_date: 2014-11-04T11:32:49Z [Term] id: GO:0097680 name: double-strand break repair via classical nonhomologous end joining namespace: biological_process def: "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining)." [GOC:rph, PMID:18584027] synonym: "C-NHEJ" RELATED [] synonym: "canonical nonhomologous end joining" EXACT [] is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: paola creation_date: 2014-12-17T15:15:18Z [Term] id: GO:0097681 name: double-strand break repair via alternative nonhomologous end joining namespace: biological_process def: "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, http://en.wikipedia.org/wiki/Microhomology-mediated_end_joining, PMID:18584027, PMID:21655080] synonym: "A-NHEJ" RELATED [] synonym: "alt-NHEJ" RELATED [] synonym: "double-strand break repair via microhomology-mediated end joining" EXACT [] synonym: "MMEJ" RELATED [] is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: paola creation_date: 2014-12-17T15:17:45Z [Term] id: GO:0097682 name: intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:ha, PMID:24375408] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity created_by: paola creation_date: 2014-12-17T16:50:30Z [Term] id: GO:0097683 name: dinoflagellate apex namespace: cellular_component def: "The anterior most point of a dinoflagellate epicone." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "apex" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097613 ! dinoflagellate epicone created_by: paola creation_date: 2014-12-18T09:29:51Z [Term] id: GO:0097684 name: dinoflagellate antapex namespace: cellular_component def: "The anterior most point of a dinoflagellate hypocone." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "antapex" BROAD [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097614 ! dinoflagellate hypocone created_by: paola creation_date: 2014-12-18T09:32:10Z [Term] id: GO:0097685 name: dinoflagellate apical groove namespace: cellular_component def: "A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate#Morphology, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. synonym: "apical groove" BROAD [] is_a: GO:0097610 ! cell surface furrow relationship: part_of GO:0097613 ! dinoflagellate epicone created_by: paola creation_date: 2014-12-18T09:34:52Z [Term] id: GO:0097686 name: dinoflagellate apical horn namespace: cellular_component def: "A horn-shaped dinoflagellate apex found in thecate species." [GOC:at, http://species-identification.org] is_a: GO:0097683 ! dinoflagellate apex created_by: paola creation_date: 2014-12-18T09:38:15Z [Term] id: GO:0097687 name: dinoflagellate antapical horn namespace: cellular_component def: "A horn-shaped dinoflagellate antapex found in thecate species." [GOC:at, http://species-identification.org] is_a: GO:0097684 ! dinoflagellate antapex created_by: paola creation_date: 2014-12-18T09:39:57Z [Term] id: GO:0097688 name: glutamate receptor clustering namespace: biological_process def: "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane." [GOC:krc, PMID:19723286] synonym: "glutamatergic receptor clustering" EXACT [] is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering created_by: paola creation_date: 2015-02-11T11:49:13Z [Term] id: GO:0097690 name: iron ion transmembrane transporter inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an iron ion transmembrane transporter." [GOC:BHF, GOC:kom, PMID:15514116] comment: An example of this is human hepcidin (UniProt symbol P81172), which regulates iron transport out of cells (see PMID:15514116). synonym: "iron channel inhibitor activity" EXACT [] is_a: GO:0098772 ! molecular function regulator intersection_of: GO:0098772 ! molecular function regulator intersection_of: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity relationship: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity [Term] id: GO:0097691 name: bacterial extracellular vesicle namespace: cellular_component def: "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells." [GOC:aa, PMID:25704309] is_a: GO:1903561 ! extracellular vesicle created_by: paola creation_date: 2015-09-24T11:31:44Z [Term] id: GO:0097692 name: histone H3-K4 monomethylation namespace: biological_process def: "The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone." [GOC:jh2, PMID:26320581] is_a: GO:0051568 ! histone H3-K4 methylation created_by: paola creation_date: 2015-11-05T11:23:15Z [Term] id: GO:0097693 name: ocelloid namespace: cellular_component def: "Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids." [GOC:ar, PMID:26131935] is_a: GO:0043229 ! intracellular organelle relationship: has_part GO:0005739 ! mitochondrion relationship: has_part GO:0009536 ! plastid created_by: paola creation_date: 2015-11-13T14:27:01Z [Term] id: GO:0097694 name: establishment of RNA localization to telomere namespace: biological_process def: "The directed movement of RNA to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433] synonym: "establishment of RNA localisation to telomere" EXACT [] is_a: GO:0051236 ! establishment of RNA localization created_by: paola creation_date: 2015-12-22T09:33:43Z [Term] id: GO:0097695 name: establishment of protein-containing complex localization to telomere namespace: biological_process def: "The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433] synonym: "establishment of macromolecular complex localisation to telomere" EXACT [] synonym: "establishment of macromolecular complex localization to telomere" RELATED [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0070200 ! establishment of protein localization to telomere relationship: part_of GO:0070727 ! cellular macromolecule localization created_by: paola creation_date: 2015-12-22T09:38:13Z [Term] id: GO:0097696 name: receptor signaling pathway via STAT namespace: biological_process def: "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:rjd, PMID:21534947, PMID:24587195] comment: In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins. synonym: "kinase activated-STAT cascade" EXACT [] synonym: "kinase-STAT cascade" EXACT [] synonym: "STAT signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: paola creation_date: 2015-12-22T10:40:14Z [Term] id: GO:0097697 name: tRNA 5-carboxymethoxyuridine methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule." [GOC:imk, PMID:26681692] is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity created_by: paola creation_date: 2016-01-07T10:36:46Z [Term] id: GO:0097698 name: telomere maintenance via base-excision repair namespace: biological_process def: "A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:24703901] is_a: GO:0006284 ! base-excision repair is_a: GO:0043247 ! telomere maintenance in response to DNA damage created_by: paola creation_date: 2016-01-07T11:15:39Z [Term] id: GO:0097699 name: vascular endothelial cell response to fluid shear stress namespace: biological_process def: "Any response to fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] synonym: "blood vessel endothelial cell response to fluid shear stress" EXACT [] is_a: GO:0071498 ! cellular response to fluid shear stress created_by: paola creation_date: 2016-01-27T12:37:32Z [Term] id: GO:0097700 name: vascular endothelial cell response to laminar fluid shear stress namespace: biological_process def: "Any response to laminar fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] synonym: "blood vessel endothelial cell response to laminar fluid shear stress" EXACT [] is_a: GO:0071499 ! cellular response to laminar fluid shear stress is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress created_by: paola creation_date: 2016-01-27T12:42:01Z [Term] id: GO:0097701 name: response to pulsatile fluid shear stress namespace: biological_process def: "Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] is_a: GO:0034405 ! response to fluid shear stress created_by: paola creation_date: 2016-01-27T14:13:31Z [Term] id: GO:0097702 name: response to oscillatory fluid shear stress namespace: biological_process def: "Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] is_a: GO:0034405 ! response to fluid shear stress created_by: paola creation_date: 2016-01-27T14:17:08Z [Term] id: GO:0097703 name: cellular response to pulsatile fluid shear stress namespace: biological_process def: "Any response to pulsatile fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] is_a: GO:0071498 ! cellular response to fluid shear stress is_a: GO:0097701 ! response to pulsatile fluid shear stress created_by: paola creation_date: 2016-01-27T14:18:23Z [Term] id: GO:0097704 name: cellular response to oscillatory fluid shear stress namespace: biological_process def: "Any response to oscillatory fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] is_a: GO:0071498 ! cellular response to fluid shear stress is_a: GO:0097702 ! response to oscillatory fluid shear stress created_by: paola creation_date: 2016-01-27T14:20:54Z [Term] id: GO:0097705 name: vascular endothelial cell response to pulsatile fluid shear stress namespace: biological_process def: "Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] synonym: "blood vessel endothelial cell response to pulsatile fluid shear stress" EXACT [] is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress is_a: GO:0097703 ! cellular response to pulsatile fluid shear stress created_by: paola creation_date: 2016-01-27T14:22:44Z [Term] id: GO:0097706 name: vascular endothelial cell response to oscillatory fluid shear stress namespace: biological_process def: "Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] synonym: "blood vessel endothelial cell response to oscillatory fluid shear stress" EXACT [] is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress is_a: GO:0097704 ! cellular response to oscillatory fluid shear stress created_by: paola creation_date: 2016-01-27T14:25:34Z [Term] id: GO:0097707 name: ferroptosis namespace: biological_process def: "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes." [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443] synonym: "iron-dependent programmed cell death" RELATED [] is_a: GO:0012501 ! programmed cell death created_by: paola creation_date: 2016-03-03T12:51:18Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005622 ! intracellular created_by: paola creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097709 name: connective tissue replacement namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:25590961] is_a: GO:0048771 ! tissue remodeling created_by: paola creation_date: 2016-05-17T10:49:10Z [Term] id: GO:0097710 name: viral terminase, small subunit namespace: cellular_component def: "The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit." [GOC:ch, GOC:jh2, PMID:18687036] comment: This term should only be used when the small subunit consists of more than one polypeptide. synonym: "virus terminase, small subunit" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043493 ! viral terminase complex created_by: paola creation_date: 2016-06-07T12:45:00Z [Term] id: GO:0097711 name: ciliary basal body-plasma membrane docking namespace: biological_process def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235, Reactome:R-HSA-5620912.1] comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. synonym: "anchoring of the basal body to the plasma membrane" RELATED [] synonym: "ciliary basal body docking" EXACT [] xref: Reactome:R-HSA-5620912.1 is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0060271 ! cilium assembly created_by: paola creation_date: 2016-08-05T16:12:33Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: part_of GO:0060271 ! cilium assembly created_by: paola creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097713 name: dolichol-phosphate-mannose synthase regulator activity namespace: molecular_function def: "Binds to and modulates the activity of dolichol-phosphate-mannose synthase." [GOC:vw, PMID:10835346] is_a: GO:0030234 ! enzyme regulator activity created_by: paola creation_date: 2016-08-23T11:19:37Z [Term] id: GO:0097714 name: response to viscosity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416] is_a: GO:0009628 ! response to abiotic stimulus created_by: paola creation_date: 2016-08-23T14:32:46Z [Term] id: GO:0097715 name: cellular response to viscosity namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416] is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0097714 ! response to viscosity created_by: paola creation_date: 2016-08-23T14:34:05Z [Term] id: GO:0097716 name: copper ion transport across blood-brain barrier namespace: biological_process def: "The directed movement of copper (Cu) ions passing through the blood-brain barrier." [GOC:sl, PMID:24614235] synonym: "copper ion transport across BBB" RELATED [] is_a: GO:0006825 ! copper ion transport is_a: GO:0150104 ! transport across blood-brain barrier created_by: paola creation_date: 2016-08-23T14:35:54Z [Term] id: GO:0097717 name: copper ion transport across blood-cerebrospinal fluid barrier namespace: biological_process def: "The directed movement of copper (Cu) ions passing through the blood-cerebrospinal fluid barrier." [GOC:sl, PMID:24614235] synonym: "copper ion transport across BCB" RELATED [] synonym: "copper ion transport across blood-CSF barrier" EXACT [] is_a: GO:0006825 ! copper ion transport created_by: paola creation_date: 2016-08-23T14:37:33Z [Term] id: GO:0097718 name: disordered domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a disordered domain of a protein." [GOC:gg, PMID:11746698] synonym: "disordered protein domain specific binding" RELATED [] is_a: GO:0019904 ! protein domain specific binding created_by: paola creation_date: 2016-08-23T16:42:51Z [Term] id: GO:0097719 name: neural tissue regeneration namespace: biological_process def: "The regrowth of neural tissue following its loss or destruction." [http://en.wikipedia.org/wiki/Neuroregeneration] synonym: "neuroregeneration" RELATED [] is_a: GO:0042246 ! tissue regeneration created_by: paola creation_date: 2016-08-25T13:14:27Z [Term] id: GO:0097720 name: calcineurin-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] synonym: "calcineurin signaling" RELATED [] synonym: "calcineurin-mediated signalling" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling created_by: paola creation_date: 2016-08-25T15:22:21Z [Term] id: GO:0097721 name: ciliary vesicle namespace: cellular_component def: "A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle." [GOC:cilia, PMID:13978319, PMID:25686250] synonym: "CV" RELATED [PMID:2568625] synonym: "primary ciliary vesicle" EXACT [PMID:20427320] is_a: GO:0031410 ! cytoplasmic vesicle created_by: paola creation_date: 2016-08-30T13:54:38Z [Term] id: GO:0097722 name: sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc] subset: gocheck_do_not_annotate synonym: "sperm movement" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0048870 ! cell motility created_by: paola creation_date: 2016-09-01T12:00:45Z [Term] id: GO:0097723 name: amoeboid sperm motility namespace: biological_process def: "Any process involved in the controlled movement of an amoeboid sperm cell." [GOC:cilia, GOC:krc] synonym: "ameboid sperm motility" EXACT [] synonym: "ameboid sperm movement" EXACT [] synonym: "amoeboid sperm movement" EXACT [] is_a: GO:0097722 ! sperm motility created_by: paola creation_date: 2016-09-01T12:02:19Z [Term] id: GO:0097725 name: histone H3-K79 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone." [GOC:hbye, PMID:27541139] synonym: "histone H3 K79 dimethylation" EXACT [] synonym: "histone lysine H3 K79 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0034729 ! histone H3-K79 methylation created_by: paola creation_date: 2016-09-15T12:41:13Z [Term] id: GO:0097726 name: LEM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)." [GOC:rz, InterPro:IPR003887, PMID:22399800] synonym: "lamina-associated polypeptide, emerin, MAN1 domain binding" EXACT [] synonym: "LAP2, emerin, MAN1 domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding created_by: paola creation_date: 2016-09-19T10:19:02Z [Term] id: GO:0097727 name: blepharoplast namespace: cellular_component def: "An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell." [GOC:cilia, GOC:tb, PMID:22691130, PMID:25047614] comment: The blepharoplast should not be confused with a basal body; rather, it acts as the precursor assembly zone for multiple basal bodies. is_a: GO:0043232 ! intracellular non-membrane-bounded organelle created_by: paola creation_date: 2016-09-23T10:57:18Z [Term] id: GO:0097728 name: 9+0 motile cilium namespace: cellular_component def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:10330409, PMID:22118931] comment: This type of cilia may be present in solitary (classic nodal cilia in embryonic nodes) or in multiple copies (e.g. in the choroid plexus epithelium). synonym: "motile 9+0 cilium" EXACT [] synonym: "nodal cilium" NARROW [] is_a: GO:0031514 ! motile cilium relationship: has_part GO:0036156 ! inner dynein arm relationship: has_part GO:0036157 ! outer dynein arm relationship: has_part GO:0097545 ! axonemal outer doublet created_by: paola creation_date: 2016-09-27T15:24:37Z [Term] id: GO:0097729 name: 9+2 motile cilium namespace: cellular_component def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931] comment: This type of cilia may be present in solitary (so-called flagella, e.g. in sperm) or in multiple copies (so-called conventional motile cilia, e.g. in tracheal epithelium, ependyma or oviduct epithelium). synonym: "conventional motile cilium" NARROW [] synonym: "motile 9+2 cilium" EXACT [] synonym: "sperm flagellum" NARROW [] is_a: GO:0031514 ! motile cilium relationship: has_part GO:0036156 ! inner dynein arm relationship: has_part GO:0036157 ! outer dynein arm relationship: has_part GO:0097540 ! axonemal central pair relationship: has_part GO:0097545 ! axonemal outer doublet created_by: paola creation_date: 2016-09-27T15:26:34Z [Term] id: GO:0097730 name: non-motile cilium namespace: cellular_component alt_id: GO:0031513 def: "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "immotile cilium" EXACT [] synonym: "immotile primary cilium" RELATED [] synonym: "nonmotile cilium" EXACT [] synonym: "nonmotile primary cilia" RELATED [] synonym: "nonmotile primary cilium" RELATED [] synonym: "sensory cilium" RELATED [] is_a: GO:0005929 ! cilium created_by: paola creation_date: 2016-09-29T14:02:11Z [Term] id: GO:0097731 name: 9+0 non-motile cilium namespace: cellular_component def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931] comment: This type of cilia may be present in solitary (authentic primary cilia in many cell types) or in multiple copies (e.g. in Grueneberg ganglion neurons). synonym: "9+0 immotile cilium" EXACT [] synonym: "non-motile 9+0 cilium" EXACT [] synonym: "primary cilium" NARROW [] is_a: GO:0097730 ! non-motile cilium created_by: paola creation_date: 2016-09-29T14:05:03Z [Term] id: GO:0097732 name: 9+2 non-motile cilium namespace: cellular_component def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:21307074, PMID:22118931] comment: This type of cilia may be present in solitary (e.g. in inner hair cells) or in multiple copies (e.g. in olfactory neurons). synonym: "9+2 immotile cilium" RELATED [] synonym: "non-motile 9+2 cilium" EXACT [] is_a: GO:0097730 ! non-motile cilium relationship: has_part GO:0036157 ! outer dynein arm created_by: paola creation_date: 2016-09-29T14:07:33Z [Term] id: GO:0097733 name: photoreceptor cell cilium namespace: cellular_component def: "A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, http://en.wikipedia.org/wiki/Photoreceptor_cell#Histology] synonym: "photoreceptor cilium" EXACT [] is_a: GO:0043005 ! neuron projection is_a: GO:0097731 ! 9+0 non-motile cilium created_by: paola creation_date: 2016-09-30T10:50:11Z [Term] id: GO:0097734 name: extracellular exosome biogenesis namespace: biological_process def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] synonym: "exosome assembly or secretion" EXACT [] synonym: "exosome biogenesis" EXACT [] synonym: "exosome production" EXACT [] synonym: "ILV assembly" RELATED [] synonym: "intraluminal vesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis created_by: paola creation_date: 2016-10-03T14:35:25Z [Term] id: GO:0097735 name: DIM/DIP cell wall layer namespace: cellular_component def: "A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds." [GOC:pr] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009275 ! Gram-positive-bacterium-type cell wall created_by: paola creation_date: 2016-10-05T14:55:30Z [Term] id: GO:0097736 name: aerial mycelium formation namespace: biological_process def: "The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae." [GOC:di, PMID:12832397] synonym: "aerial hyphal growth" RELATED [] synonym: "fertile mycelium formation" RELATED [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0048856 ! anatomical structure development created_by: paola creation_date: 2016-10-14T14:25:22Z [Term] id: GO:0097737 name: acquisition of mycelium reproductive competence namespace: biological_process def: "A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium." [GOC:di, PMID:23864594] synonym: "mycelium developmental competence" RELATED [] is_a: GO:0032502 ! developmental process created_by: paola creation_date: 2016-10-14T16:36:09Z [Term] id: GO:0097738 name: substrate mycelium formation namespace: biological_process def: "The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate." [GOC:di, PMID:10021365] is_a: GO:0019954 ! asexual reproduction is_a: GO:0048856 ! anatomical structure development created_by: paola creation_date: 2016-10-18T16:21:05Z [Term] id: GO:0097739 name: negative regulation of ferrichrome biosynthetic process in response to iron namespace: biological_process def: "Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus." [GOC:al] is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process relationship: part_of GO:0071281 ! cellular response to iron ion created_by: paola creation_date: 2016-10-18T17:00:24Z [Term] id: GO:0097740 name: paraflagellar rod namespace: cellular_component def: "A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling." [GOC:cilia, PMID:19879876, PMID:26199333, PMID:26688619] synonym: "PFR" RELATED [] is_a: GO:0099080 ! supramolecular complex relationship: part_of GO:0097729 ! 9+2 motile cilium created_by: paola creation_date: 2016-10-19T11:30:08Z [Term] id: GO:0097741 name: mastigoneme namespace: cellular_component def: "A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum." [GOC:cilia, http://en.wikipedia.org/wiki/Mastigoneme, PMID:943397] is_a: GO:0099080 ! supramolecular complex relationship: part_of GO:0031514 ! motile cilium created_by: paola creation_date: 2016-10-19T11:33:38Z [Term] id: GO:0097742 name: de novo centriole assembly namespace: biological_process def: "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects." [GOC:cilia, PMID:25047614, PMID:25291643] synonym: "acentriolar basal body biogenesis" RELATED [] synonym: "de novo basal body amplification" RELATED [] synonym: "de novo basal body assembly" RELATED [] synonym: "de novo basal body biogenesis" RELATED [] synonym: "de novo basal body generation" RELATED [] synonym: "de novo centriole amplification" RELATED [] synonym: "de novo ciliary basal body assembly" RELATED [] synonym: "multiciliation" RELATED [] synonym: "multiciliogenesis" RELATED [] is_a: GO:0098534 ! centriole assembly created_by: paola creation_date: 2016-10-19T15:13:50Z [Term] id: GO:0097743 name: de novo centriole assembly via blepharoplast namespace: biological_process def: "A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface." [GOC:cilia, PMID:25047614] synonym: "multiciliation" RELATED [] synonym: "multiciliogenesis" RELATED [] is_a: GO:0097742 ! de novo centriole assembly created_by: paola creation_date: 2016-10-19T15:18:34Z [Term] id: GO:0097744 name: urate salt excretion namespace: biological_process def: "The elimination by an organism of urate salt or uric acid." [CHEBI:46819, GOC:jl, http://en.wikipedia.org/wiki/Uric_acid#Biology] synonym: "urate excretion" BROAD [] is_a: GO:0007588 ! excretion created_by: paola creation_date: 2016-10-27T11:35:59Z [Term] id: GO:0097745 name: mitochondrial tRNA 5'-end processing namespace: biological_process def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477] is_a: GO:0000964 ! mitochondrial RNA 5'-end processing is_a: GO:0090646 ! mitochondrial tRNA processing is_a: GO:0099116 ! tRNA 5'-end processing created_by: paola creation_date: 2016-11-08T10:50:51Z [Term] id: GO:0097746 name: regulation of blood vessel diameter namespace: biological_process alt_id: GO:0042312 alt_id: GO:0050880 def: "Any process that modulates the diameter of blood vessels." [GOC:pr] synonym: "regulation of blood vessel size" RELATED [] synonym: "regulation of vasodilatation" RELATED [] synonym: "regulation of vasodilation" RELATED [] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0035296 ! regulation of tube diameter relationship: part_of GO:0008015 ! blood circulation created_by: paola creation_date: 2016-11-24T15:45:05Z [Term] id: GO:0097747 name: RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [GOC:pf] is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: paola creation_date: 2016-12-02T11:48:55Z [Term] id: GO:0097748 name: 3'-5' RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end." [GOC:pf, PMID:22456265, PMID:27484477] xref: RHEA:57528 is_a: GO:0097747 ! RNA polymerase activity created_by: paola creation_date: 2016-12-02T11:51:31Z [Term] id: GO:0097749 name: membrane tubulation namespace: biological_process def: "A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules)." [GOC:pr] is_a: GO:0061024 ! membrane organization created_by: paola creation_date: 2016-12-21T12:32:24Z [Term] id: GO:0097750 name: endosome membrane tubulation namespace: biological_process def: "A membrane tubulation process occurring in an endosome membrane." [GOC:bc, GOC:PARL, PMID:26911690] synonym: "endosomal membrane tubulation" EXACT [] is_a: GO:0007032 ! endosome organization is_a: GO:0097749 ! membrane tubulation created_by: paola creation_date: 2016-12-21T12:33:09Z [Term] id: GO:0097751 name: spore-bearing structure formation namespace: biological_process def: "The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di] synonym: "sporangium formation" BROAD [] synonym: "sporophore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0075259 ! spore-bearing structure development created_by: paola creation_date: 2017-01-11T13:55:24Z [Term] id: GO:0097752 name: regulation of DNA stability namespace: biological_process def: "Any process that modulates the stability of DNA." [GOC:pr] is_a: GO:0065008 ! regulation of biological quality created_by: paola creation_date: 2017-01-24T11:23:01Z [Term] id: GO:0097753 name: membrane bending namespace: biological_process def: "A membrane organization process resulting in the bending of a membrane." [GOC:krc, GOC:pr, GOC:vw, http://en.wikipedia.org/wiki/Membrane_curvature] synonym: "membrane curvature" RELATED [] is_a: GO:0061024 ! membrane organization created_by: paola creation_date: 2017-01-25T16:37:06Z [Term] id: GO:0097754 name: clathrin-mediated membrane bending namespace: biological_process def: "A membrane bending process mediated by clathrin." [GOC:pr, http://en.wikipedia.org/wiki/Membrane_curvature] is_a: GO:0097753 ! membrane bending relationship: has_part GO:0048268 ! clathrin coat assembly created_by: paola creation_date: 2017-01-25T16:38:42Z [Term] id: GO:0097755 name: positive regulation of blood vessel diameter namespace: biological_process alt_id: GO:0045909 def: "Any process that increases the diameter of blood vessels." [GOC:pr] synonym: "positive regulation of vasodilation" RELATED [] is_a: GO:0097746 ! regulation of blood vessel diameter created_by: paola creation_date: 2017-02-08T15:33:21Z [Term] id: GO:0097756 name: negative regulation of blood vessel diameter namespace: biological_process alt_id: GO:0045908 def: "Any process that decreases the diameter of blood vessels." [GOC:pr] synonym: "negative regulation of vasodilation" RELATED [] is_a: GO:0097746 ! regulation of blood vessel diameter created_by: paola creation_date: 2017-02-08T15:36:16Z [Term] id: GO:0098001 name: receptor-mediated bacteriophage reversible attachment to host cell namespace: biological_process def: "Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection." [GOC:bm, PHI:0000005] comment: This process was historically defined by the release, by Waring blending or sonication, by dilution and centrifugation, or by filtration and washing, of infective virions from their complexes with cells, thus contrary to what is observed after irreversible adsorption. synonym: "phage reversible adsorption" RELATED [GOC:bm] synonym: "reversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] is_a: GO:0098671 ! adhesion receptor-mediated virion attachment to host cell created_by: brenley [Term] id: GO:0098002 name: receptor-mediated bacteriophage irreversible attachment to host cell namespace: biological_process def: "The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell." [GOC:bm, PHI:0000006] synonym: "irreversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] synonym: "phage irreversible adsorption" RELATED [GOC:bm] is_a: GO:0098670 ! entry receptor-mediated virion attachment to host cell created_by: brenley [Term] id: GO:0098003 name: viral tail assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm, PHI:0000015] synonym: "bacteriophage tail assembly" NARROW [GOC:bm] synonym: "virus tail assembly" EXACT [GOC:bf, GOC:jl] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly created_by: brenley creation_date: 2012-07-18T16:01:59Z [Term] id: GO:0098004 name: virus tail fiber assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm, PHI:0000011] is_a: GO:0016032 ! viral process relationship: part_of GO:0098003 ! viral tail assembly created_by: brenley creation_date: 2012-07-18T16:08:15Z [Term] id: GO:0098005 name: viral head-tail joining namespace: biological_process def: "Process by which virus heads and tails are attached to each other." [GOC:bm, PHI:0000012] synonym: "phage head tail joining" NARROW [GOC:bm] synonym: "virus head-tail joining" EXACT [GOC:bf, GOC:jl] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly created_by: brenley creation_date: 2012-07-18T16:11:59Z [Term] id: GO:0098006 name: viral DNA genome packaging, headful namespace: biological_process def: "The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full." [GOC:bm, PHI:0000020] comment: Generalized transducing phages usually use this mode of DNA packaging. synonym: "phage headful packaging" NARROW [GOC:bm] is_a: GO:0019073 ! viral DNA genome packaging created_by: brenley creation_date: 2012-07-18T16:15:09Z [Term] id: GO:0098009 name: viral terminase, large subunit namespace: cellular_component def: "The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit." [GOC:bm, GOC:ch, GOC:jh2, PHI:0000073, PMID:18687036] comment: This term should only be used when the large subunit consists of more than one polypeptide. synonym: "virus terminase, large subunit" EXACT [] is_a: GO:1904949 ! ATPase complex relationship: part_of GO:0043493 ! viral terminase complex created_by: brenley creation_date: 2012-07-25T10:13:00Z [Term] id: GO:0098015 name: virus tail namespace: cellular_component def: "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm, PHI:0000174] comment: Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell. synonym: "bacteriophage tail" NARROW [GOC:bm] synonym: "viral tail" RELATED [GOC:bf] is_a: GO:0044423 ! virion part created_by: brenley creation_date: 2012-07-18T17:04:46Z [Term] id: GO:0098017 name: viral capsid, major subunit namespace: cellular_component def: "The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits." [GOC:bm, PHI:0000066] synonym: "major capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl] synonym: "major head protein" RELATED [PHI:0000066] is_a: GO:0046727 ! capsomere created_by: brenley creation_date: 2012-07-19T11:21:21Z [Term] id: GO:0098018 name: viral capsid, minor subunit namespace: cellular_component def: "The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits." [GOC:bm, PHI:00000185] synonym: "minor capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl] synonym: "minor head protein" RELATED [PHI:0000185] is_a: GO:0046727 ! capsomere created_by: brenley creation_date: 2012-07-19T11:28:18Z [Term] id: GO:0098019 name: obsolete virus tail, major subunit namespace: cellular_component def: "OBSOLETE. The part of the viral tail that comprises the most common subunit type." [GOC:bm, PHI:0000082] comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages. synonym: "major tail protein" RELATED [PHI:0000082] is_obsolete: true created_by: brenley creation_date: 2012-07-19T11:32:55Z [Term] id: GO:0098020 name: obsolete virus tail, minor subunit namespace: cellular_component def: "OBSOLETE. The part of the viral tail that comprises the least common subunit type." [GOC:bm, PHI:0000178] comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages. synonym: "bacteriophage minor protein subunit" NARROW [GOC:bm] synonym: "minor tail protein" RELATED [GOC:bm] is_obsolete: true created_by: brenley creation_date: 2012-07-19T11:36:25Z [Term] id: GO:0098021 name: viral capsid, decoration namespace: cellular_component def: "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm, PHI:0000069] synonym: "decoration protein" RELATED [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid created_by: brenley creation_date: 2012-07-19T11:52:53Z [Term] id: GO:0098022 name: viral capsid, fiber namespace: cellular_component def: "A type of capsid decoration composed of fiber structures." [GOC:bm, PHI:0000070, PHI:0000176] synonym: "head/capsid fiber" RELATED [GOC:bm] xref: PHI:0000070 "phage head/capsid fiber protein" xref: PHI:0000176 "phage head/capsid fiber" is_a: GO:0098021 ! viral capsid, decoration created_by: brenley creation_date: 2012-07-19T11:56:32Z [Term] id: GO:0098023 name: virus tail, tip namespace: cellular_component def: "The basal end of the virus tail, which is used by the virus to attach to the host cell." [GOC:bm, PHI:0000087] synonym: "bacteriophage tail tip" NARROW [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:13:02Z [Term] id: GO:0098024 name: virus tail, fiber namespace: cellular_component def: "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm, PHI:0000024, PHI:0000175] comment: For tailed bacteriophages, fibers typically bind to particular Lipopolysaccharide (LPS), polysaccharide or protein receptors on the cell surface. synonym: "bacteriophage tail fiber" NARROW [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:14:50Z [Term] id: GO:0098025 name: virus tail, baseplate namespace: cellular_component def: "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm, PHI:0000088] comment: Tail fibers are often attached to the baseplate of Caudovirales (tailed bacteriophages with dsDNA genomes). Sometimes referred to as the tail tip or tip structure in Siphoviridae. synonym: "bacteriophage baseplate" NARROW [GOC:bm] synonym: "tail structure" RELATED [GOC:bm] synonym: "tail tip" RELATED [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:16:51Z [Term] id: GO:0098026 name: virus tail, tube namespace: cellular_component def: "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm, PHI:0000026] comment: Applies in particular the Myoviridae bacteriophages. synonym: "bacteriophage tail tube" NARROW [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:21:28Z [Term] id: GO:0098027 name: virus tail, sheath namespace: cellular_component def: "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm, PHI:0000084] synonym: "bacteriophage tail sheath" NARROW [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:23:27Z [Term] id: GO:0098028 name: virus tail, shaft namespace: cellular_component def: "The tube of the non-contractile tails of some viruses." [GOC:bm, PHI:0000085] comment: This term applies in particular to the Siphoviridae bacteriophages, where the shaft is the channel for DNA translocation into the host cytoplasm. synonym: "bacteriophage tail shaft" NARROW [GOC:bm] is_a: GO:0044423 ! virion part relationship: part_of GO:0098015 ! virus tail created_by: brenley creation_date: 2012-07-19T14:24:28Z [Term] id: GO:0098029 name: icosahedral viral capsid, spike namespace: cellular_component def: "A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell." [GOC:bm, PHI:0000208] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: brenley creation_date: 2012-07-19T14:37:11Z [Term] id: GO:0098030 name: icosahedral viral capsid, neck namespace: cellular_component def: "A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae)." [GOC:bm, PHI:0000205, PHI:0000309] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: brenley creation_date: 2012-07-19T14:56:28Z [Term] id: GO:0098031 name: icosahedral viral capsid, collar namespace: cellular_component def: "A small disk located at the base of some icosahedral virus capsids." [GOC:bm, PHI:0000206, PHI:0000308] is_a: GO:0044423 ! virion part relationship: part_of GO:0019030 ! icosahedral viral capsid created_by: brenley creation_date: 2012-07-19T15:01:12Z [Term] id: GO:0098032 name: icosahedral viral capsid, collar fiber namespace: cellular_component def: "A fiber attached to the collar structure of some icosahedral viral capsids." [GOC:bm, PHI:0000207, PHI:0000307] is_a: GO:0098022 ! viral capsid, fiber relationship: part_of GO:0098031 ! icosahedral viral capsid, collar created_by: brenley creation_date: 2012-07-19T15:05:16Z [Term] id: GO:0098033 name: icosahedral viral capsid, neck fiber namespace: cellular_component def: "A fiber attached to the neck at the base of some icosahedral viral capsids." [GOC:bm, PHI:0000075, PHI:0000310] is_a: GO:0098022 ! viral capsid, fiber relationship: part_of GO:0098030 ! icosahedral viral capsid, neck created_by: brenley creation_date: 2012-07-19T15:07:39Z [Term] id: GO:0098035 name: viral DNA genome packaging via site-specific sequence recognition namespace: biological_process def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase." [GOC:bm] is_a: GO:0019073 ! viral DNA genome packaging relationship: has_part GO:0019071 ! viral DNA cleavage involved in viral genome maturation created_by: brenley creation_date: 2012-07-20T11:36:49Z [Term] id: GO:0098036 name: viral DNA genome packaging, 3' extended cos packaging namespace: biological_process def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends." [GOC:bm, PHI:0000021] is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition created_by: brenley creation_date: 2012-07-20T11:38:40Z [Term] id: GO:0098037 name: viral DNA genome packaging, 5' extended cos packaging namespace: biological_process def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends." [GOC:bm, PHI:0000022] is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition created_by: brenley creation_date: 2012-07-20T11:40:47Z [Term] id: GO:0098038 name: non-replicative transposition, DNA-mediated namespace: biological_process def: "Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition." [GOC:bm, PHI:0000137, PMID:2553270] synonym: "cut-and-paste transposition" EXACT [GOC:bm] is_a: GO:0006313 ! transposition, DNA-mediated created_by: brenley creation_date: 2012-07-20T16:47:50Z [Term] id: GO:0098039 name: replicative transposition, DNA-mediated namespace: biological_process def: "Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition." [GOC:bm, PMID:10540284] synonym: "copy-and-paste transposition" EXACT [GOC:bm] synonym: "transpositional DNA genome replication" EXACT [PHI:0000037] is_a: GO:0006313 ! transposition, DNA-mediated relationship: has_part GO:0006260 ! DNA replication created_by: brenley creation_date: 2012-07-20T16:52:02Z [Term] id: GO:0098045 name: virus baseplate assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a virus baseplate." [GOC:bm, PHI:0000328] is_a: GO:0016032 ! viral process relationship: part_of GO:0098003 ! viral tail assembly created_by: brenley creation_date: 2012-07-25T14:50:32Z [Term] id: GO:0098046 name: type V protein secretion system complex namespace: cellular_component def: "A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc)." [GOC:bf, GOC:bhm, PMID:15119822, PMID:15590781] comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. synonym: "autotransporter system complex" NARROW [PMID:15590781, Wikipedia:Secretion] synonym: "T5SS complex" EXACT [Wikipedia:Secretion] is_a: GO:0032991 ! protein-containing complex created_by: rfoulger creation_date: 2012-08-01T10:05:49Z [Term] id: GO:0098061 name: viral capsid, internal space namespace: cellular_component def: "The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins." [GOC:bm] synonym: "internal head protein" EXACT [GOC:bm] is_a: GO:0044423 ! virion part created_by: brenley creation_date: 2012-08-01T12:12:47Z [Term] id: GO:0098501 name: polynucleotide dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a polynucleotide." [GOC:DOS] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0016311 ! dephosphorylation is_a: GO:0043170 ! macromolecule metabolic process created_by: davidos creation_date: 2013-09-18T14:49:10Z [Term] id: GO:0098502 name: DNA dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a DNA molecule." [GOC:DOS] is_a: GO:0016311 ! dephosphorylation created_by: davidos creation_date: 2013-09-18T14:50:16Z [Term] id: GO:0098503 name: obsolete DNA 3' dephosphorylation namespace: biological_process def: "OBSOLETE. The process of removing a 3' phosphate group from a DNA molecule." [GOC:DOS] comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process. is_obsolete: true created_by: davidos creation_date: 2013-09-18T14:51:17Z [Term] id: GO:0098504 name: obsolete DNA 3' dephosphorylation involved in DNA repair namespace: biological_process def: "OBSOLETE. Any 3' DNA dephosphorylation that is involved in the process of DNA repair." [GOC:DOS, PMID:11729194] comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process. is_obsolete: true created_by: davidos creation_date: 2013-09-18T14:52:15Z [Term] id: GO:0098505 name: G-rich strand telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] is_a: GO:0043047 ! single-stranded telomeric DNA binding created_by: davidos creation_date: 2013-09-23T13:16:24Z [Term] id: GO:0098506 name: polynucleotide 3' dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from the 3' end of a polynucleotide." [GOC:dos] is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0098507 name: polynucleotide 5' dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from the 5' end of a polynucleotide." [GOC:dos] is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0098508 name: endothelial to hematopoietic transition namespace: biological_process def: "The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium." [PMID:20154732, PMID:22521721] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0060232 ! delamination created_by: davidos creation_date: 2013-09-24T15:20:39Z [Term] id: GO:0098509 name: sensory perception of humidity namespace: biological_process def: "The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908, PMID:8650222] comment: Note, this is not classified under 'detection of chemical stimulus' as there are various potential mechanisms of hygroperception including detection of mechanical stimulus. synonym: "hygrosensory perception" EXACT [PMID:8650222] is_a: GO:0007600 ! sensory perception created_by: davidos creation_date: 2013-09-25T13:52:27Z [Term] id: GO:0098510 name: sensory perception of high humidity namespace: biological_process def: "The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908] is_a: GO:0098509 ! sensory perception of humidity created_by: davidos creation_date: 2013-09-25T13:57:27Z [Term] id: GO:0098511 name: sensory perception of low humidity namespace: biological_process def: "The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908] is_a: GO:0098509 ! sensory perception of humidity created_by: davidos creation_date: 2013-09-25T14:02:02Z [Term] id: GO:0098512 name: detection of humidity stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity." [GOC:dos, PMID:8650222] is_a: GO:0050906 ! detection of stimulus involved in sensory perception is_a: GO:0098513 ! detection of humidity intersection_of: GO:0098513 ! detection of humidity intersection_of: part_of GO:0098509 ! sensory perception of humidity relationship: part_of GO:0098509 ! sensory perception of humidity created_by: davidos creation_date: 2013-09-25T14:09:25Z [Term] id: GO:0098513 name: detection of humidity namespace: biological_process def: "The series of events in which a humidity stimulus is received and converted into a molecular signal." [GOC:dos] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus created_by: davidos creation_date: 2013-09-25T14:11:13Z [Term] id: GO:0098514 name: detection of high humidity stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity." [GOC:dos, PMID:18269908] is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception is_a: GO:0098516 ! detection of high humidity intersection_of: GO:0098516 ! detection of high humidity intersection_of: part_of GO:0098510 ! sensory perception of high humidity relationship: part_of GO:0098510 ! sensory perception of high humidity created_by: davidos creation_date: 2013-09-25T14:20:54Z [Term] id: GO:0098515 name: detection of low humidity stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity." [GOC:dos, PMID:18269908] is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception is_a: GO:0098517 ! detection of low humidity intersection_of: GO:0098517 ! detection of low humidity intersection_of: part_of GO:0098511 ! sensory perception of low humidity relationship: part_of GO:0098511 ! sensory perception of low humidity created_by: davidos creation_date: 2013-09-25T14:24:29Z [Term] id: GO:0098516 name: detection of high humidity namespace: biological_process def: "The series of events in which high humidity is detected and converted into a molecular signal." [GOC:dos] is_a: GO:0098513 ! detection of humidity created_by: davidos creation_date: 2013-09-25T14:26:47Z [Term] id: GO:0098517 name: detection of low humidity namespace: biological_process def: "The series of events in which low humidity is detected and converted into a molecular signal." [GOC:dos] is_a: GO:0098513 ! detection of humidity created_by: davidos creation_date: 2013-09-25T14:27:18Z [Term] id: GO:0098518 name: polynucleotide phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] is_a: GO:0016791 ! phosphatase activity relationship: part_of GO:0098501 ! polynucleotide dephosphorylation created_by: davidos creation_date: 2013-09-26T11:02:35Z [Term] id: GO:0098519 name: nucleotide phosphatase activity, acting on free nucleotides namespace: molecular_function def: "Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate." [GOC:dos] comment: To be used for NTP->NDP or NDP -> NMP. For nucleotide -> nucleoside (all phosphates removed) use nucleotidase. synonym: "nucleotide phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity created_by: davidos creation_date: 2013-09-26T11:04:45Z [Term] id: GO:0098520 name: excitatory neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction." [GOC:dos] is_a: GO:0031594 ! neuromuscular junction is_a: GO:0060076 ! excitatory synapse created_by: davidos creation_date: 2013-10-14T12:02:51Z [Term] id: GO:0098521 name: inhibitory neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction." [GOC:dos] comment: Inhibitory neuromuscular junctions are found in arthropods but not in vertebrates. is_a: GO:0031594 ! neuromuscular junction is_a: GO:0060077 ! inhibitory synapse created_by: davidos creation_date: 2013-10-14T12:04:08Z [Term] id: GO:0098522 name: neuromuscular junction of skeletal muscle fiber namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. is_a: GO:0098520 ! excitatory neuromuscular junction is_a: GO:0098523 ! neuromuscular junction of myotube is_a: GO:0098981 ! cholinergic synapse created_by: davidos creation_date: 2013-10-14T12:04:32Z [Term] id: GO:0098523 name: neuromuscular junction of myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. is_a: GO:0031594 ! neuromuscular junction created_by: davidos creation_date: 2013-10-14T12:05:12Z [Term] id: GO:0098524 name: neuromuscular junction of somatic muscle myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell." [GOC:dos] is_a: GO:0098523 ! neuromuscular junction of myotube is_a: GO:0098527 ! neuromuscular junction of somatic muscle created_by: davidos creation_date: 2013-10-14T12:05:43Z [Term] id: GO:0098525 name: excitatory neuromuscular junction of somatic myotube namespace: cellular_component def: "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells." [GOC:dos] is_a: GO:0098520 ! excitatory neuromuscular junction is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube created_by: davidos creation_date: 2013-10-14T12:06:08Z [Term] id: GO:0098526 name: inhibitory neuromuscular junction of somatic myotube namespace: cellular_component def: "A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods." [GOC:dos] is_a: GO:0098521 ! inhibitory neuromuscular junction is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube created_by: davidos creation_date: 2013-10-14T12:06:43Z [Term] id: GO:0098527 name: neuromuscular junction of somatic muscle namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods." [GOC:dos] is_a: GO:0031594 ! neuromuscular junction created_by: davidos creation_date: 2013-10-14T12:07:05Z [Term] id: GO:0098528 name: skeletal muscle fiber differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos] is_a: GO:0014902 ! myotube differentiation is_a: GO:0035914 ! skeletal muscle cell differentiation created_by: davidos creation_date: 2013-10-15T14:00:34Z [Term] id: GO:0098529 name: neuromuscular junction development, skeletal muscle fiber namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber." [GOC:mtg_OBO2OWL_2013] is_a: GO:0007528 ! neuromuscular junction development relationship: part_of GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0098530 name: positive regulation of strand invasion namespace: biological_process def: "Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dos, GOC:dph, GOC:elh, GOC:tb] synonym: "positive regulation of D-loop biosynthesis" RELATED [GOC:elh] synonym: "positive regulation of D-loop formation" RELATED [GOC:elh] synonym: "positive regulation of Rad51-mediated strand invasion" EXACT [GOC:elh] is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0060542 ! regulation of strand invasion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042148 ! strand invasion relationship: positively_regulates GO:0042148 ! strand invasion created_by: davidos creation_date: 2013-10-16T12:15:59Z [Term] id: GO:0098531 name: ligand-activated transcription factor activity namespace: molecular_function def: "A DNA-binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors." [GOC:dos, http://www.ecocyc.org/ECOLI/NEW-IMAGE?object=BC-3.1.2.3] synonym: "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity, direct ligand regulated sequence-specific DNA binding" EXACT [] is_a: GO:0003700 ! DNA-binding transcription factor activity created_by: davidos creation_date: 2013-10-17T15:51:30Z [Term] id: GO:0098532 name: histone H3-K27 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone." [PMID:19270745] is_a: GO:0070734 ! histone H3-K27 methylation created_by: davidos creation_date: 2013-10-18T14:11:17Z [Term] id: GO:0098533 name: ATPase dependent transmembrane transport complex namespace: cellular_component def: "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane." [GOC:dos] comment: The location of this complex is implicit in its activity, so its location is asserted as a regular relationship rather than as a part of an intersection. is_a: GO:1902495 ! transmembrane transporter complex created_by: davidos creation_date: 2013-10-22T12:12:52Z [Term] id: GO:0098534 name: centriole assembly namespace: biological_process def: "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0070925 ! organelle assembly created_by: davidos creation_date: 2013-10-22T15:55:22Z [Term] id: GO:0098535 name: de novo centriole assembly involved in multi-ciliated epithelial cell differentiation namespace: biological_process def: "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997] comment: In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "centriole amplification" RELATED [PMID:24075808] synonym: "de novo centriole assembly" BROAD [] synonym: "de novo centriole assembly via deuterosome" EXACT [] synonym: "deuterosomal basal body biogenesis" RELATED [] synonym: "deuterosome pathway" RELATED [PMID:25047614] synonym: "deuterosome-mediated centriole biogenesis" RELATED [PMID:24075808] synonym: "multiciliation" RELATED [] synonym: "multiciliogenesis" RELATED [] is_a: GO:0097742 ! de novo centriole assembly intersection_of: GO:0097742 ! de novo centriole assembly intersection_of: part_of GO:1903251 ! multi-ciliated epithelial cell differentiation relationship: part_of GO:1903251 ! multi-ciliated epithelial cell differentiation created_by: davidos creation_date: 2013-10-22T16:03:13Z [Term] id: GO:0098536 name: deuterosome namespace: cellular_component def: "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles." [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle created_by: davidos creation_date: 2013-10-22T16:21:19Z [Term] id: GO:0098537 name: lobed nucleus namespace: cellular_component def: "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm] is_a: GO:0005634 ! nucleus created_by: davidos creation_date: 2013-10-22T18:31:36Z [Term] id: GO:0098538 name: lumenal side of transport vesicle membrane namespace: cellular_component def: "The side (leaflet) of the transport vesicle membrane that faces the lumen." [GOC:ab] synonym: "internal side of transport vesicle membrane" EXACT [] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0030658 ! transport vesicle membrane created_by: davidos creation_date: 2013-10-24T11:43:55Z [Term] id: GO:0098539 name: cytoplasmic side of transport vesicle membrane namespace: cellular_component def: "The side (leaflet) of the transport vesicle membrane that faces the cytoplasm." [GOC:ab] synonym: "external side of transport vesicle membrane" EXACT [] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0030658 ! transport vesicle membrane created_by: davidos creation_date: 2013-10-24T11:48:07Z [Term] id: GO:0098540 name: lumenal side of trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen." [GOC:ab] synonym: "internal side of trans-Golgi network transport vesicle membrane" RELATED [] is_a: GO:0098538 ! lumenal side of transport vesicle membrane relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane created_by: davidos creation_date: 2013-10-24T11:55:02Z [Term] id: GO:0098541 name: cytoplasmic side of trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm." [GOC:ab] synonym: "external side of trans-Golgi network transport vesicle membrane" EXACT [] is_a: GO:0098539 ! cytoplasmic side of transport vesicle membrane relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane created_by: davidos creation_date: 2013-10-24T11:56:30Z [Term] id: GO:0098542 name: defense response to other organism namespace: biological_process def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism created_by: davidos creation_date: 2013-11-11T12:59:11Z [Term] id: GO:0098543 name: detection of other organism namespace: biological_process alt_id: GO:0051824 def: "The series of events in which a stimulus from another organism is received and converted into a molecular signal." [GOC:dos] comment: Merged terms, see https://github.com/geneontology/go-ontology/issues/17977 synonym: "recognition of other organism during symbiotic interaction" NARROW [GOC:dph] synonym: "recognition of other organism involved in symbiotic interaction" NARROW [] is_a: GO:0044419 ! interspecies interaction between organisms is_a: GO:0051707 ! response to other organism is_a: GO:0098581 ! detection of external biotic stimulus created_by: davidos creation_date: 2013-11-11T14:28:54Z [Term] id: GO:0098544 name: maintenance of protein complex location namespace: biological_process def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0051235 ! maintenance of location created_by: davidos creation_date: 2013-11-15T18:20:16Z [Term] id: GO:0098545 name: maintenance of protein complex location in cytoplasm namespace: biological_process def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0098544 ! maintenance of protein complex location relationship: occurs_in GO:0005737 ! cytoplasm created_by: davidos creation_date: 2013-11-15T20:49:15Z [Term] id: GO:0098546 name: 2',5-3',5'-cyclic GMP-AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with c[G(2',5')pA(2',5')p], a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages." [GOC:dos, PMID:23910378] synonym: "c[G(2',5')pA(3',5')p] binding" EXACT [PMID:23910378] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding created_by: davidos creation_date: 2013-12-03T15:31:39Z [Term] id: GO:0098547 name: lumenal side of Golgi membrane namespace: cellular_component def: "The side of the Golgi membrane that faces the lumen." [GOC:ab, GOC:dos] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0000139 ! Golgi membrane created_by: davidos creation_date: 2013-12-03T10:44:23Z [Term] id: GO:0098548 name: cytoplasmic side of Golgi membrane namespace: cellular_component def: "The side (leaflet) of the Golgi membrane that faces the cytoplasm." [GOC:ab, GOC:dos] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0000139 ! Golgi membrane created_by: davidos creation_date: 2013-12-03T10:49:33Z [Term] id: GO:0098549 name: somatic ring canal namespace: cellular_component def: "A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects." [GOC:dos, PMID:22135360, PMID:670316] is_a: GO:0045171 ! intercellular bridge [Term] id: GO:0098550 name: lumenal side of early endosome membrane namespace: cellular_component def: "The side (leaflet) of the early endosome membrane that faces the lumen." [GOC:lr] synonym: "internal leaflet of early endosome membrane" EXACT [GOC:ab] synonym: "internal side of early endosome membrane" EXACT [] is_a: GO:0098565 ! lumenal side of endosome membrane relationship: part_of GO:0031901 ! early endosome membrane [Term] id: GO:0098551 name: lumenal side of late endosome membrane namespace: cellular_component def: "The side (leaflet) of the late endosome membrane that faces the lumen." [GOC:lr] synonym: "internal leaflet of late endosome membrane" EXACT [GOC:ab] synonym: "internal side of late endosome membrane" EXACT [] is_a: GO:0098565 ! lumenal side of endosome membrane relationship: part_of GO:0031902 ! late endosome membrane [Term] id: GO:0098552 name: side of membrane namespace: cellular_component def: "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0097478 ! leaflet of membrane bilayer relationship: part_of GO:0016020 ! membrane created_by: davidos creation_date: 2013-12-03T11:28:04Z [Term] id: GO:0098553 name: lumenal side of endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:08:37Z [Term] id: GO:0098554 name: cytoplasmic side of endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:09:47Z [Term] id: GO:0098555 name: lumenal side of rough endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos] is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:13:24Z [Term] id: GO:0098556 name: cytoplasmic side of rough endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:15:44Z [Term] id: GO:0098557 name: cytoplasmic side of smooth endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:17:58Z [Term] id: GO:0098558 name: lumenal side of smooth endoplasmic reticulum membrane namespace: cellular_component def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos] is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane created_by: davidos creation_date: 2013-12-03T12:19:28Z [Term] id: GO:0098559 name: cytoplasmic side of early endosome membrane namespace: cellular_component def: "The side (leaflet) of the early endosome membrane that faces the cytoplasm." [GOC:lr] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "external leaflet of early endosome membrane" EXACT [GOC:ab] synonym: "external side of early endosome membrane" EXACT [] is_a: GO:0010009 ! cytoplasmic side of endosome membrane relationship: part_of GO:0031901 ! early endosome membrane [Term] id: GO:0098560 name: cytoplasmic side of late endosome membrane namespace: cellular_component def: "The side (leaflet) of the late endosome membrane that faces the cytoplasm." [GOC:lr] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "external leaflet of late endosome membrane" EXACT [GOC:ab] synonym: "external side of late endosome membrane" EXACT [] is_a: GO:0010009 ! cytoplasmic side of endosome membrane relationship: part_of GO:0031902 ! late endosome membrane [Term] id: GO:0098561 name: methyl accepting chemotaxis protein complex namespace: cellular_component def: "A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus." [GOC:dos, PMID:1326408, PMID:15802240] comment: A number of complexes of this class are found in E.coli. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0098562 name: cytoplasmic side of membrane namespace: cellular_component def: "The side of a membrane that faces the cytoplasm." [GOC:dos] is_a: GO:0098552 ! side of membrane created_by: davidos creation_date: 2013-12-12T11:21:30Z [Term] id: GO:0098563 name: intrinsic component of synaptic vesicle membrane namespace: cellular_component def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0030672 ! synaptic vesicle membrane relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0098564 name: trans-Golgi network transport vesicle lumen namespace: cellular_component def: "The volume enclosed within the membrane of a trans-Golgi network transport vesicle." [GOC:dos] is_a: GO:0005796 ! Golgi lumen is_a: GO:0098566 ! transport vesicle lumen relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0098565 name: lumenal side of endosome membrane namespace: cellular_component def: "The side (leaflet) of the endosome membrane that faces the lumen." [GOC:dos] synonym: "internal leaflet of endosome membrane" EXACT [GOC:ab] synonym: "internal side of endosome membrane" EXACT [] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0098566 name: transport vesicle lumen namespace: cellular_component def: "The volume enclosed within the membrane of a transport vesicle." [GOC:dos] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0098567 name: periplasmic side of plasma membrane namespace: cellular_component def: "The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface." [GOC:dos] is_a: GO:0009897 ! external side of plasma membrane created_by: davidos creation_date: 2013-12-19T09:31:30Z [Term] id: GO:0098568 name: external side of mycolate outer membrane namespace: cellular_component def: "The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface." [GOC:dos, PMID:18316738, PMID:18567661] is_a: GO:0031240 ! external side of cell outer membrane [Term] id: GO:0098569 name: internal side of mycolate outer membrane namespace: cellular_component def: "The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network." [GOC:dos, PMID:18316738, PMID:18567661] is_a: GO:0098552 ! side of membrane [Term] id: GO:0098570 name: stromal side of plastid inner membrane namespace: cellular_component def: "The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0098571 name: lumenal side of plastid thylakoid membrane namespace: cellular_component def: "The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0055035 ! plastid thylakoid membrane [Term] id: GO:0098572 name: stromal side of plastid thylakoid membrane namespace: cellular_component def: "The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0055035 ! plastid thylakoid membrane [Term] id: GO:0098573 name: intrinsic component of mitochondrial membrane namespace: cellular_component def: "The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] synonym: "intrinsic to mitochondrial membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031966 ! mitochondrial membrane relationship: part_of GO:0031966 ! mitochondrial membrane [Term] id: GO:0098574 name: cytoplasmic side of lysosomal membrane namespace: cellular_component def: "The side (leaflet) of the lysosomal membrane that faces the cytoplasm." [GOC:ab, GOC:dos] synonym: "external leaflet of lysosomal membrane" EXACT [GOC:dos] synonym: "external side of lysosomal membrane" EXACT [] is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0098575 name: lumenal side of lysosomal membrane namespace: cellular_component def: "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] synonym: "internal leaflet of lysosomal membrane" EXACT [GOC:ab] synonym: "internal side of lysosomal membrane" EXACT [] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0098576 name: lumenal side of membrane namespace: cellular_component def: "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] is_a: GO:0098552 ! side of membrane relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0098577 name: inactive sex chromosome namespace: cellular_component def: "A sex chromosome that has been inactivated." [GOC:dos] synonym: "inactivated sex chromosome" EXACT [] is_a: GO:0000803 ! sex chromosome [Term] id: GO:0098578 name: condensed chromatin of inactivated sex chromosome namespace: cellular_component def: "A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation." [GOC:dos] is_a: GO:0001739 ! sex chromatin intersection_of: GO:0005720 ! nuclear heterochromatin intersection_of: part_of GO:0098577 ! inactive sex chromosome relationship: part_of GO:0098577 ! inactive sex chromosome [Term] id: GO:0098579 name: active sex chromosome namespace: cellular_component def: "A sex chromosome that has not been inactivated." [GOC:dos] is_a: GO:0000803 ! sex chromosome [Term] id: GO:0098580 name: chromatin of active sex chromosome namespace: cellular_component def: "Chromatin that is part of an active sex chromosome." [GOC:dos, PMID:23816838] comment: Some gene products are known to be associated with the chromatin of active sex chromosome, but not that of inactive sex chromosomes or autosome, e.g. see: Froberg et al., 2003 (PMID:23816838). is_a: GO:0001739 ! sex chromatin intersection_of: GO:0000790 ! nuclear chromatin intersection_of: part_of GO:0098579 ! active sex chromosome relationship: part_of GO:0098579 ! active sex chromosome [Term] id: GO:0098581 name: detection of external biotic stimulus namespace: biological_process def: "The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated." [GOC:dos] synonym: "detection of exogenous biotic stimulus" EXACT [] is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0043207 ! response to external biotic stimulus created_by: davidos creation_date: 2014-01-22T14:20:16Z [Term] id: GO:0098582 name: innate vocalization behavior namespace: biological_process def: "A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur." [GOC:BHF, GOC:dos, GOC:rl] is_a: GO:0071625 ! vocalization behavior created_by: davidos creation_date: 2014-01-24T12:47:01Z [Term] id: GO:0098583 name: learned vocalization behavior namespace: biological_process def: "A vocalization behavior that is the result of learning." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] comment: Examples include human speech and learned bird song. is_a: GO:0071625 ! vocalization behavior is_a: GO:0098598 ! learned vocalization behavior or vocal learning created_by: davidos creation_date: 2014-01-24T12:48:57Z [Term] id: GO:0098584 name: host cell synaptic vesicle namespace: cellular_component def: "A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [GOC:dos] is_a: GO:0044161 ! host cell cytoplasmic vesicle relationship: part_of GO:0044221 ! host cell synapse created_by: davidos creation_date: 2014-01-24T13:14:13Z [Term] id: GO:0098585 name: host cell synaptic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a host synaptic vesicle." [GOC:dos] is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane relationship: part_of GO:0098584 ! host cell synaptic vesicle created_by: davidos creation_date: 2014-01-24T13:15:14Z [Term] id: GO:0098586 name: cellular response to virus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos] is_a: GO:0009615 ! response to virus created_by: davidos creation_date: 2014-01-24T14:54:08Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane created_by: davidos creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098589 name: membrane region namespace: cellular_component def: "A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0098805 ! whole membrane disjoint_from: GO:0098805 ! whole membrane relationship: part_of GO:0098805 ! whole membrane creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_manually_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane created_by: davidos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098591 name: external side of apical plasma membrane namespace: cellular_component def: "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:ab, GOC:dos] is_a: GO:0009897 ! external side of plasma membrane relationship: part_of GO:0016324 ! apical plasma membrane created_by: davidos creation_date: 2014-03-06T12:04:33Z [Term] id: GO:0098592 name: cytoplasmic side of apical plasma membrane namespace: cellular_component def: "The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos] is_a: GO:0009898 ! cytoplasmic side of plasma membrane relationship: part_of GO:0016324 ! apical plasma membrane created_by: davidos creation_date: 2014-03-06T12:07:32Z [Term] id: GO:0098593 name: goblet cell theca namespace: cellular_component def: "A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel." [PMID:6541604] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005856 ! cytoskeleton created_by: davidos creation_date: 2014-03-11T14:52:33Z [Term] id: GO:0098594 name: mucin granule namespace: cellular_component def: "A secretory granule that contains mucin." [PMID:16377632] is_a: GO:0030141 ! secretory granule created_by: davidos creation_date: 2014-03-11T15:59:11Z [Term] id: GO:0098595 name: perivitelline space namespace: cellular_component def: "The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane)." [GOC:dos] is_a: GO:0005576 ! extracellular region created_by: davidos creation_date: 2014-04-08T16:07:31Z [Term] id: GO:0098596 name: imitative learning namespace: biological_process def: "Learning in which new behaviors are acquired through imitation." [GOC:dos, Wikipedia:Imitative_learning&oldid=593192364] xref: Wikipedia:Imitative_learning xref: Wikipedia:Observational_learning#Observational_learning_compared_to_imitation is_a: GO:0098597 ! observational learning created_by: davidos creation_date: 2014-04-10T11:00:39Z [Term] id: GO:0098597 name: observational learning namespace: biological_process def: "Learning that occurs through observing the behavior of others." [GOC:dos, Wikipedia:Observational_learning&oldid=603524137] comment: Observation here is used in a broad sense to include perception of the behavior of others via any form or combination of forms of sensory perception (visual, auditory etc). Observational learning is broader than imitative learning in that it does not require a duplication of the behavior exhibited by the model. xref: Wikipedia:Observational_learning is_a: GO:0007612 ! learning created_by: davidos creation_date: 2014-04-10T11:07:10Z [Term] id: GO:0098598 name: learned vocalization behavior or vocal learning namespace: biological_process def: "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] comment: This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior. is_a: GO:0007611 ! learning or memory created_by: davidos creation_date: 2014-04-10T11:34:33Z [Term] id: GO:0098599 name: palmitoyl hydrolase activity namespace: molecular_function def: "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate." [GOC:dos, GOC:pg] xref: Reactome:R-HSA-5690046 "PPT2 hydrolyses PALMCoA to PALM" xref: Reactome:R-HSA-9027670 "ESTG binding induces ESR depalmitoylation" is_a: GO:0016787 ! hydrolase activity relationship: part_of GO:0098734 ! macromolecule depalmitoylation created_by: davidos creation_date: 2014-04-11T17:57:36Z [Term] id: GO:0098600 name: selenomethionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005] xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by CTH" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: davidos creation_date: 2014-04-15T15:00:28Z [Term] id: GO:0098601 name: selenomethionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986] xref: Reactome:R-HSA-2408551 "SeMet is converted to AdoSeMet by MAT" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: davidos creation_date: 2014-04-15T15:15:03Z [Term] id: GO:0098603 name: selenol Se-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine." [PMID:1711890] xref: Reactome:R-HSA-2408544 "AdoSeMet is converted to AdeSeHCys by MetTrans(1)" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0098604 name: adenosylselenohomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine." [GOC:dos, PMID:1711890, PMID:7305945] xref: Reactome:R-HSA-2408532 "AdeSeHCys is hydrolysed to SeHCys by AHCY" is_a: GO:0016802 ! trialkylsulfonium hydrolase activity created_by: davidos creation_date: 2014-04-16T10:53:22Z [Term] id: GO:0098605 name: selenocystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O." [PMID:6456763] xref: Reactome:R-HSA-2408559 "SeHCys and Ser are dehydrated into SeCysta by CBS" is_a: GO:0016836 ! hydro-lyase activity created_by: davidos creation_date: 2014-04-16T11:07:50Z [Term] id: GO:0098606 name: selenocystathionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763] xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by CTH" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: davidos creation_date: 2014-04-16T11:20:00Z [Term] id: GO:0098607 name: methylselenocysteine deselenhydrase activity namespace: molecular_function def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543] xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by CTH" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: davidos creation_date: 2014-04-16T11:24:12Z [Term] id: GO:0098608 name: methylselenol demethylase activity namespace: molecular_function def: "Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH." [PMID:17451884, PMID:17988700] xref: Reactome:R-HSA-2408530 "MeSeH is hydrolysed to H2Se by methylselenol demethylase" is_a: GO:0032451 ! demethylase activity created_by: davidos creation_date: 2014-04-16T11:28:00Z [Term] id: GO:0098609 name: cell-cell adhesion namespace: biological_process alt_id: GO:0016337 def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] synonym: "single organismal cell-cell adhesion" RELATED [] is_a: GO:0007155 ! cell adhesion created_by: davidos creation_date: 2014-04-16T13:40:03Z [Term] id: GO:0098610 name: adhesion between unicellular organisms namespace: biological_process def: "The attachment of two unicellular organisms to each other." [GOC:dos] synonym: "multi-organismal cell-cell adhesion" BROAD [] is_a: GO:0098609 ! cell-cell adhesion is_a: GO:0098740 ! multi organism cell adhesion [Term] id: GO:0098611 name: cell-cell adhesion involved in galactose-specific flocculation namespace: biological_process def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:dos, PMID:22098069] is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0036349 ! galactose-specific flocculation relationship: part_of GO:0036349 ! galactose-specific flocculation [Term] id: GO:0098612 name: cell-cell adhesion involved in mannose-specific flocculation namespace: biological_process def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:dos, PMID:22098069] is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0036350 ! mannose-specific flocculation relationship: part_of GO:0036350 ! mannose-specific flocculation [Term] id: GO:0098613 name: methaneselenol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-Adenosyl-L-methionine + Methaneselenol => S-Adenosyl-L-homocysteine + Dimethyl selenide." [PMID:14705, PMID:17988700, PMID:4380351] xref: Reactome:R-HSA-2408541 "MeSeH is methylated to Me2Se by MeSeH methyltransferase" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0098614 name: hydrogen selenide methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-Adenosyl-L-methionine + Hydrogen selenide => S-Adenosyl-L-homocysteine + Methaneselenol." [PMID:14705, PMID:17988700] xref: Reactome:R-HSA-2408536 "H2Se is methylated to MeSeH by H2Se methyltransferase" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0098615 name: dimethyl selenide methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium." [PMID:17988700, PMID:3350800] xref: Reactome:R-HSA-2408554 "Me2Se is methylated to Me3Se+ by INMT" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0098616 name: selenate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2SeO4 => Diphosphate + Adenylylselenate." [PMID:2537056] xref: Reactome:R-HSA-2408525 "H2SeO4 is converted to APSe by PAPSS1,2" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0098617 name: adenylylselenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + Adenylylselenate => ADP + 3'-Phosphoadenylylselenate." [PMID:2537056] xref: Reactome:R-HSA-2408540 "APSe is phosphorylated to PAPSe by PAPSS1,2" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0098618 name: selenomethionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-Selenomethionine + tRNA(Met) => AMP + Diphosphate + Selenomethionyl-tRNA(Met)." [PMID:16661668, PMID:16661782] xref: Reactome:R-HSA-2408546 "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0098619 name: selenocysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: tRNASec + L-Ser + ATP ---> Ser-tRNASec + AMP + Diphosphate." [PMID:8890909, PMID:9431993, PMID:9637248] xref: Reactome:R-HSA-2408526 "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0098620 name: seryl-selenocysteinyl-tRNA kinase activity namespace: molecular_function def: "Catalysis of the reaction: Ser-tRNA(Sec) + ATP ---> Sep-tRNA(Sec) + ADP" [PMID:15317934] xref: Reactome:R-HSA-2408507 "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0098621 name: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: O-Phosphoseryl-tRNA(Sec) + Selenophosphoric acid + H2O => L-Selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919] xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by SEPSECS tetramer" is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0098622 name: selenodiglutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+." [PMID:1569062] xref: Reactome:R-HSA-2408542 "GSSeSG is reduced to GSSeH and GSH by GSR" is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0098623 name: selenite reductase activity namespace: molecular_function def: "Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ ---> H2Se + 3NADP+ + 3H2O." [PMID:1321713] xref: Reactome:R-HSA-2408558 "SeO3(2-) is reduced to H2Se by TXNRD1" is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0098624 name: 3'-Phosphoadenylylselenate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-Phosphoadenylylselenate + NADPH => Adenosine 3',5'-bisphosphate + Selenite + NADP+ + H+." [PMID:14723223] synonym: "PAPSe reductase activity" EXACT [PMID:14723223] xref: Reactome:R-HSA-2408548 "PAPSe is reduced to SeO3(2-) by PAPSe reductase" is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0098625 name: methylselenol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O" [PMID:11782468] xref: Reactome:R-HSA-5263614 "MeSeOH is reduced to MeSeH by TXNRD1" is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0098626 name: methylseleninic acid reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O." [PMID:11782468] xref: Reactome:R-HSA-5263616 "MeSeO2H is reduced to MeSeOH by TXNRD1" is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0098627 name: protein arginine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate." [PMID:23770242] comment: Made part of peptidyl-N-phospho-arginine phosphatase activity on the assumption that arginine phosphorylation in proteins occurs via an N link. is_a: GO:0004721 ! phosphoprotein phosphatase activity relationship: part_of GO:0098628 ! peptidyl-N-phospho-arginine dephosphorylation created_by: davidos creation_date: 2014-04-17T17:57:39Z [Term] id: GO:0098628 name: peptidyl-N-phospho-arginine dephosphorylation namespace: biological_process def: "The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine" [PMID:23770242] is_a: GO:0006470 ! protein dephosphorylation created_by: davidos creation_date: 2014-04-17T18:03:31Z [Term] id: GO:0098629 name: trans-Golgi network membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane." [GOC:di, GOC:dos, PMID:23345439] is_a: GO:0061024 ! membrane organization [Term] id: GO:0098630 name: aggregation of unicellular organisms namespace: biological_process def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos] synonym: "aggregation of single cell organisms" EXACT [] is_a: GO:0051704 ! multi-organism process is_a: GO:0098743 ! cell aggregation [Term] id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell." [Wikipedia:Cell_adhesion] synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: part_of GO:0007155 ! cell adhesion relationship: part_of GO:0007155 ! cell adhesion [Term] id: GO:0098632 name: cell-cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] synonym: "cell-cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell-cell adhesion" EXACT [] is_a: GO:0005515 ! protein binding is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: part_of GO:0098609 ! cell-cell adhesion relationship: part_of GO:0098609 ! cell-cell adhesion [Term] id: GO:0098633 name: collagen fibril binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collagen fibril." [GOC:dos, PMID:21421911] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0098634 name: cell-matrix adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix." [Wikipedia:Cell_adhesion] synonym: "cell-matrix adhesion molecule" EXACT [] synonym: "protein binding involved in cell-matrix adhesion" EXACT [] is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005488 ! binding intersection_of: part_of GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0098635 name: protein complex involved in cell-cell adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0098636 ! protein complex involved in cell adhesion [Term] id: GO:0098636 name: protein complex involved in cell adhesion namespace: cellular_component alt_id: GO:1990307 def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos] synonym: "cell adhesion complex" RELATED [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0098637 name: protein complex involved in cell-matrix adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion." [GOC:dos] is_a: GO:0098636 ! protein complex involved in cell adhesion [Term] id: GO:0098638 name: laminin binding involved in cell-matrix adhesion namespace: molecular_function def: "Any laminin protein binding that occurs as part of cell-matrix adhesion." [GOC:dos] is_a: GO:0043236 ! laminin binding is_a: GO:0098634 ! cell-matrix adhesion mediator activity intersection_of: GO:0043236 ! laminin binding intersection_of: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0098639 name: collagen binding involved in cell-matrix adhesion namespace: molecular_function def: "Any collagen binding that occurs as part of cell-matrix adhesion." [GOC:dos] is_a: GO:0005518 ! collagen binding is_a: GO:0098634 ! cell-matrix adhesion mediator activity intersection_of: GO:0005518 ! collagen binding intersection_of: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0098640 name: integrin binding involved in cell-matrix adhesion namespace: molecular_function def: "Any integrin binding that occurs as part of the process of cell-matrix adhesion." [GOC:dos] is_a: GO:0005178 ! integrin binding is_a: GO:0098634 ! cell-matrix adhesion mediator activity intersection_of: GO:0005178 ! integrin binding intersection_of: part_of GO:0007160 ! cell-matrix adhesion [Term] id: GO:0098641 name: cadherin binding involved in cell-cell adhesion namespace: molecular_function def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0045296 ! cadherin binding is_a: GO:0098632 ! cell-cell adhesion mediator activity intersection_of: GO:0045296 ! cadherin binding intersection_of: part_of GO:0098609 ! cell-cell adhesion [Term] id: GO:0098642 name: network-forming collagen trimer namespace: cellular_component def: "A collagen trimer that forms networks." [PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098645 ! collagen network relationship: part_of GO:0098645 ! collagen network [Term] id: GO:0098643 name: banded collagen fibril namespace: cellular_component def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers is_a: GO:0099512 ! supramolecular fiber [Term] id: GO:0098644 name: complex of collagen trimers namespace: cellular_component def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos] synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541] synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911] is_a: GO:0099080 ! supramolecular complex relationship: has_part GO:0005581 ! collagen trimer relationship: part_of GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0098645 name: collagen network namespace: cellular_component def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers is_a: GO:0099081 ! supramolecular polymer [Term] id: GO:0098646 name: collagen sheet namespace: cellular_component def: "A protein complex that consists of collagen triple helices associated to form a sheet-like network." [GOC:dos, PMID:21421911] synonym: "collagen hexagonal network" EXACT [PMID:21421911] is_a: GO:0098645 ! collagen network [Term] id: GO:0098647 name: collagen beaded filament namespace: cellular_component def: "A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure." [GOC:dos, PMID:19693541] synonym: "beads on a string" RELATED [PMID:19693541] is_a: GO:0099512 ! supramolecular fiber [Term] id: GO:0098648 name: collagen anchoring fibril namespace: cellular_component def: "A specialised collagen fibril that functions as an anchor, binding to other collagen structures." [GOC:dos] is_a: GO:0098644 ! complex of collagen trimers [Term] id: GO:0098649 name: response to peptidyl-dipeptidase A inhibitor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos] synonym: "response to ACE inhibitor" NARROW [] synonym: "response to angiotensin-converting enzyme inhibitor" NARROW [] is_a: GO:0042493 ! response to drug [Term] id: GO:0098650 name: peptidyl-proline 4-dioxygenase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a peptidyl-proline 4-dioxygenase." [GOC:dos, GOC:kvm] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0098651 name: basement membrane collagen trimer namespace: cellular_component def: "Any collagen timer that is part of a basement membrane." [GOC:dos, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0005604 ! basement membrane relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0098652 name: collagen type VII anchoring fibril namespace: cellular_component def: "An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis." [PMID:19693541] is_a: GO:0098648 ! collagen anchoring fibril [Term] id: GO:0098653 name: centromere clustering namespace: biological_process alt_id: GO:0098587 def: "The process by which centromeres/kinetochores become localized to clusters." [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732] comment: As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process. synonym: "kinetochore clustering" EXACT [] is_a: GO:0050000 ! chromosome localization is_a: GO:0072765 ! centromere localization created_by: davidos creation_date: 2014-05-23T19:03:37Z [Term] id: GO:0098654 name: CENP-A recruiting complex namespace: cellular_component def: "A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere." [PMID:24774534] synonym: "MIS18 complex" NARROW [GOC:bhm, GOC:vw] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0098655 name: cation transmembrane transport namespace: biological_process alt_id: GO:0099132 def: "The process in which a cation is transported across a membrane." [GOC:dos, GOC:vw] synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0098656 name: anion transmembrane transport namespace: biological_process alt_id: GO:0099133 def: "The process in which an anion is transported across a membrane." [GOC:dos, GOC:vw] synonym: "ATP hydrolysis coupled anion transmembrane transport" NARROW [] is_a: GO:0006820 ! anion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0006810 ! transport [Term] id: GO:0098658 name: inorganic anion import across plasma membrane namespace: biological_process def: "The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic anion import into cell" EXACT [] is_a: GO:0098661 ! inorganic anion transmembrane transport is_a: GO:0099587 ! inorganic ion import across plasma membrane [Term] id: GO:0098659 name: inorganic cation import across plasma membrane namespace: biological_process def: "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic cation import into cell" EXACT [] is_a: GO:0098662 ! inorganic cation transmembrane transport is_a: GO:0099587 ! inorganic ion import across plasma membrane [Term] id: GO:0098660 name: inorganic ion transmembrane transport namespace: biological_process def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic ion membrane transport" EXACT [] synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0098661 name: inorganic anion transmembrane transport namespace: biological_process def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic anion membrane transport" EXACT [] synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:0098660 ! inorganic ion transmembrane transport [Term] id: GO:0098662 name: inorganic cation transmembrane transport namespace: biological_process def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic cation membrane transport" EXACT [] synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0098655 ! cation transmembrane transport is_a: GO:0098660 ! inorganic ion transmembrane transport [Term] id: GO:0098663 name: obsolete transmembrane transporter activity involved in import into cell namespace: molecular_function def: "OBSOLETE. Any transmembrane transporter activity that is involved in importing some substance into a cell." [GOC:dos] comment: The reason for obsoletion is that this terms partly represents a process ("import into cell"). See https://github.com/geneontology/go-ontology/issues/14322 for discussion. is_obsolete: true [Term] id: GO:0098664 name: G protein-coupled serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway created_by: dos creation_date: 2016-12-21T12:07:58Z [Term] id: GO:0098665 name: serotonin receptor complex namespace: cellular_component def: "A protein complex that is capable of serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] synonym: "5-HT receptor complex" EXACT [] synonym: "5-hydroxytryptamine receptor complex" EXACT [] synonym: "5HT receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex created_by: dos creation_date: 2016-12-21T12:24:56Z [Term] id: GO:0098666 name: G protein-coupled serotonin receptor complex namespace: cellular_component def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie] synonym: "G-protein coupled serotonin receptor complex" EXACT [] is_a: GO:0098665 ! serotonin receptor complex is_a: GO:0098878 ! neurotransmitter receptor complex created_by: dos creation_date: 2016-12-21T12:28:12Z [Term] id: GO:0098669 name: superinfection exclusion namespace: biological_process def: "The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented." [PMID:11985726, PMID:23692331, PMID:24089557, PMID:8012757, VZ:3971] xref: VZ:3971 is_a: GO:0016032 ! viral process created_by: dos creation_date: 2017-01-16T17:25:21Z [Term] id: GO:0098670 name: entry receptor-mediated virion attachment to host cell namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration." [PMID:18351291, VZ:3942] synonym: "viral attachment to host entry receptor" EXACT [VZ:3942] xref: VZ:3942 is_a: GO:0046813 ! receptor-mediated virion attachment to host cell created_by: dos creation_date: 2017-01-16T13:18:27Z [Term] id: GO:0098671 name: adhesion receptor-mediated virion attachment to host cell namespace: biological_process def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located." [PMID:18351291, VZ:3943] synonym: "viral attachment to host adhesion receptor" EXACT [VZ:3943] xref: VZ:3943 is_a: GO:0046813 ! receptor-mediated virion attachment to host cell created_by: dos creation_date: 2017-01-16T13:22:54Z [Term] id: GO:0098672 name: evasion by virus of CRISPR-cas system namespace: biological_process def: "Any process, either active or passive, by which a virus evades the CRISPR-cas system of its host. Some viruses can directly suppress the CRISPR system." [PMID:23242138, PMID:23446421, PMID:26416740, VZ:3962] synonym: "CRISPR-cas system evasion by virus" EXACT [VZ:3962] xref: VZ:3962 is_a: GO:0019049 ! mitigation of host defenses by virus created_by: dos creation_date: 2017-01-16T13:38:27Z [Term] id: GO:0098673 name: inhibition of host DNA replication by virus namespace: biological_process def: "Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication." [PMID:17010157, PMID:21205014] is_a: GO:0019054 ! modulation by virus of host cellular process created_by: dos creation_date: 2017-01-17T15:58:15Z [Term] id: GO:0098674 name: extrinsic component of neuronal dense core vesicle membrane namespace: cellular_component def: "The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] subset: goslim_synapse is_a: GO:0098922 ! extrinsic component of dense core granule membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0099012 ! neuronal dense core vesicle membrane relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane created_by: dos creation_date: 2017-01-17T16:20:56Z [Term] id: GO:0098675 name: intrinsic component of neuronal dense core vesicle membrane namespace: cellular_component def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to neuronal dense core granule membrane" EXACT [] is_a: GO:0098956 ! intrinsic component of dense core granule membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0099012 ! neuronal dense core vesicle membrane relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane created_by: dos creation_date: 2017-01-17T16:22:44Z [Term] id: GO:0098676 name: modulation of host virulence by virus namespace: biological_process def: "Any process by which a virus modulates the ability of its host to infect and/or damage an organism for which it is a host. Typically this involves a phage modulating the virulence of a bacterium. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production exotoxins or provide protection against host immune defenses." [PMID:10913072, PMID:11553559, PMID:23981100, VZ:3965] xref: VZ:3965 is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0009405 ! pathogenesis created_by: dos creation_date: 2017-01-19T11:59:46Z [Term] id: GO:0098677 name: virion maturation namespace: biological_process def: "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection." [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946] synonym: "viral particle maturation" EXACT [] synonym: "virus particle maturation" RELATED [] xref: UniProtKB-KW:KW-0917 xref: VZ:1946 is_a: GO:0016032 ! viral process relationship: part_of GO:0019075 ! virus maturation created_by: dos creation_date: 2017-01-19T12:49:22Z [Term] id: GO:0098678 name: viral tropism switching namespace: biological_process def: "A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase." [PMID:6232613, VZ:4498] xref: VZ:4498 is_a: GO:0016032 ! viral process created_by: dos creation_date: 2017-01-19T13:05:51Z [Term] id: GO:0098679 name: obsolete regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate catabloism." [PMID:16408318] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of carbohydrate catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [] is_obsolete: true created_by: dos creation_date: 2017-01-31T14:46:21Z [Term] id: GO:0098680 name: template-free RNA nucleotidyltransferase namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:nc, PMID:15994230] is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: dos creation_date: 2017-01-31T15:51:56Z [Term] id: GO:0098681 name: synaptic ribbon namespace: cellular_component def: "A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical." [PMID:15626493] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle created_by: dos creation_date: 2017-02-05T15:59:43Z [Term] id: GO:0098682 name: arciform density namespace: cellular_component def: "An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane." [PMID:15626493] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0097470 ! ribbon synapse created_by: dos creation_date: 2017-02-05T16:12:22Z [Term] id: GO:0098683 name: cochlear hair cell ribbon synapse namespace: cellular_component def: "A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density." [PMID:15626493] subset: goslim_synapse is_a: GO:0097470 ! ribbon synapse created_by: dos creation_date: 2017-02-05T16:16:49Z [Term] id: GO:0098684 name: photoreceptor ribbon synapse namespace: cellular_component def: "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon." [PMID:15626493] subset: goslim_synapse is_a: GO:0097470 ! ribbon synapse created_by: dos creation_date: 2017-02-05T16:26:27Z [Term] id: GO:0098685 name: Schaffer collateral - CA1 synapse namespace: cellular_component def: "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689] subset: goslim_synapse is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-02-05T16:29:43Z [Term] id: GO:0098686 name: hippocampal mossy fiber to CA3 synapse namespace: cellular_component def: "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell." [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762] subset: goslim_synapse is_a: GO:0098984 ! neuron to neuron synapse intersection_of: GO:0045202 ! synapse intersection_of: has_part GO:0097464 ! thorny excrescence intersection_of: has_part GO:1990026 ! hippocampal mossy fiber expansion relationship: has_part GO:0097464 ! thorny excrescence relationship: has_part GO:1990026 ! hippocampal mossy fiber expansion created_by: dos creation_date: 2017-02-05T16:29:58Z [Term] id: GO:0098687 name: chromosomal region namespace: cellular_component def: "Any subdivision of a chromosome along its length." [GOC:dos] comment: Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome region" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome [Term] id: GO:0098688 name: parallel fiber to Purkinje cell synapse namespace: cellular_component def: "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells." [PMID:16623829, PMID:3209740] subset: goslim_synapse is_a: GO:0060076 ! excitatory synapse created_by: dos creation_date: 2017-02-21T18:32:05Z [Term] id: GO:0098689 name: latency-replication decision namespace: biological_process def: "The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic swtich controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli." [PMID:19416825, PMID:24339346, VZ:3964] synonym: "Latency-replication switch" EXACT [] synonym: "lytic switch" EXACT [] synonym: "prophage induction" NARROW [] synonym: "proviral induction" EXACT [] synonym: "proviral switch" EXACT [] synonym: "reactivation of latent virus" EXACT [] xref: PHI:0000062 xref: VZ:3964 is_a: GO:0016032 ! viral process is_a: GO:0050792 ! regulation of viral process relationship: regulates GO:0019046 ! release from viral latency created_by: dos creation_date: 2017-02-28T11:24:26Z [Term] id: GO:0098690 name: glycinergic synapse namespace: cellular_component def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-03-07T14:50:33Z [Term] id: GO:0098691 name: dopaminergic synapse namespace: cellular_component def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-03-07T14:51:52Z [Term] id: GO:0098692 name: noradrenergic synapse namespace: cellular_component def: "A synapse that uses noradrenaline as a neurotransmitter." [GOC:dos] is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-03-07T14:57:24Z [Term] id: GO:0098693 name: regulation of synaptic vesicle cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle." [GOC:dos] subset: goslim_synapse is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099504 ! synaptic vesicle cycle relationship: regulates GO:0099504 ! synaptic vesicle cycle created_by: dos creation_date: 2017-03-21T16:06:48Z [Term] id: GO:0098694 name: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0033043 ! regulation of organelle organization is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis is_a: GO:1902803 ! regulation of synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane relationship: regulates GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane created_by: dos creation_date: 2017-04-04T17:03:29Z [Term] id: GO:0098695 name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels namespace: molecular_function def: "Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos] subset: goslim_synapse synonym: "IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT [] is_a: GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity intersection_of: GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2017-04-04T17:07:09Z [Term] id: GO:0098696 name: regulation of neurotransmitter receptor localization to postsynaptic specialization membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0065008 ! regulation of biological quality is_a: GO:1902683 ! regulation of receptor localization to synapse is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane relationship: regulates GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane created_by: dos creation_date: 2017-04-04T16:33:38Z [Term] id: GO:0098697 name: ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels namespace: molecular_function def: "Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos] subset: goslim_synapse is_a: GO:0005219 ! ryanodine-sensitive calcium-release channel activity intersection_of: GO:0005219 ! ryanodine-sensitive calcium-release channel activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2017-04-04T17:11:38Z [Term] id: GO:0098698 name: postsynaptic specialization assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0070925 ! organelle assembly is_a: GO:0099084 ! postsynaptic specialization organization relationship: part_of GO:0099068 ! postsynapse assembly created_by: dos creation_date: 2017-04-04T17:22:01Z [Term] id: GO:0098699 name: structural constituent of presynaptic actin cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0005200 ! structural constituent of cytoskeleton is_a: GO:0099181 ! structural constituent of presynapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0099143 ! presynaptic actin cytoskeleton intersection_of: part_of GO:0099140 ! presynaptic actin cytoskeleton organization relationship: occurs_in GO:0099143 ! presynaptic actin cytoskeleton relationship: part_of GO:0099140 ! presynaptic actin cytoskeleton organization created_by: dos creation_date: 2017-06-09T18:33:07Z [Term] id: GO:0098700 name: neurotransmitter loading into synaptic vesicle namespace: biological_process def: "The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps." [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342] subset: goslim_synapse synonym: "neurotransmitter import into synaptic vesicle" EXACT [] synonym: "neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342] synonym: "synaptic vesicle neurotransmitter loading" EXACT syngo_official_label [] is_a: GO:0006836 ! neurotransmitter transport relationship: part_of GO:0099504 ! synaptic vesicle cycle [Term] id: GO:0098702 name: adenine import across plasma membrane namespace: biological_process alt_id: GO:0061488 def: "The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "adenine import into cell" EXACT [] is_a: GO:0015853 ! adenine transport is_a: GO:0098739 ! import across plasma membrane is_a: GO:1904823 ! purine nucleobase transmembrane transport created_by: dph creation_date: 2012-12-06T14:51:42Z [Term] id: GO:0098703 name: calcium ion import across plasma membrane namespace: biological_process alt_id: GO:1990035 def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "calcium ion import into cell" EXACT [] synonym: "calcium ion uptake into cell" EXACT [GOC:vw] is_a: GO:0097553 ! calcium ion transmembrane import into cytosol is_a: GO:0098659 ! inorganic cation import across plasma membrane is_a: GO:1902656 ! calcium ion import into cytosol created_by: mah creation_date: 2013-02-07T13:07:59Z [Term] id: GO:0098704 name: carbohydrate import across plasma membrane namespace: biological_process alt_id: GO:0097319 def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "carbohydrate import into cell" EXACT [] is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: paola creation_date: 2012-05-31T02:45:02Z [Term] id: GO:0098705 name: copper ion import across plasma membrane namespace: biological_process alt_id: GO:0015678 alt_id: GO:1902861 def: "The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "copper cation import into cell" EXACT [CHEBI:23378] synonym: "copper ion import into cell" EXACT [] synonym: "high affinity copper ion transport" NARROW [] synonym: "high affinity copper transport" NARROW [] synonym: "high-affinity copper ion transport" NARROW [] is_a: GO:0015677 ! copper ion import is_a: GO:0015679 ! plasma membrane copper ion transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: mah creation_date: 2014-04-03T13:26:04Z [Term] id: GO:0098706 name: iron ion import across cell outer membrane namespace: biological_process alt_id: GO:0015683 alt_id: GO:0097461 def: "The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space." [GOC:mah, PMID:23192658] synonym: "ferric ion import into cell" EXACT [GOC:mah] synonym: "ferric iron import across cell outer membrane" NARROW [] synonym: "ferric iron import into cell" EXACT [] synonym: "ferric iron transmembrane transport" BROAD [] synonym: "high affinity ferric iron transport" NARROW [] synonym: "high-affinity ferric iron transmembrane transport" NARROW [] is_a: GO:0034755 ! iron ion transmembrane transport created_by: paola creation_date: 2012-12-20T08:33:03Z [Term] id: GO:0098708 name: glucose import across plasma membrane namespace: biological_process alt_id: GO:0061490 alt_id: GO:1990821 def: "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "glucose import into cell" EXACT [] synonym: "high affinity glucose import" NARROW [] is_a: GO:0046323 ! glucose import is_a: GO:0140271 ! hexose import across plasma membrane created_by: al creation_date: 2012-12-06T14:54:07Z [Term] id: GO:0098709 name: glutathione import across plasma membrane namespace: biological_process alt_id: GO:0036347 def: "The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "glutathione import into cell" EXACT [] synonym: "glutathione uptake" EXACT [GOC:bf] is_a: GO:0034775 ! glutathione transmembrane transport is_a: GO:0140207 ! tripeptide import across plasma membrane created_by: rfoulger creation_date: 2012-09-18T14:29:19Z [Term] id: GO:0098710 name: guanine import across plasma membrane namespace: biological_process alt_id: GO:0061489 def: "The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "guanine import into cell" EXACT [] is_a: GO:0098739 ! import across plasma membrane is_a: GO:1903716 ! guanine transmembrane transport created_by: dph creation_date: 2012-12-06T14:52:43Z [Term] id: GO:0098711 name: iron ion import across plasma membrane namespace: biological_process alt_id: GO:0097459 alt_id: GO:0097460 alt_id: GO:0098707 def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:mah, PMID:8321236] synonym: "ferrous ion import into cell" RELATED [GOC:mah] synonym: "ferrous iron import across plasma membrane" RELATED [] synonym: "ferrous iron import into cell" RELATED [] synonym: "iron import into cell" RELATED [GOC:mah] synonym: "iron ion import into cell" EXACT [] is_a: GO:0033212 ! iron import into cell is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: paola creation_date: 2012-12-20T08:29:00Z [Term] id: GO:0098712 name: L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1903802 alt_id: GO:1990123 def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "L-glutamate import into cell" EXACT [] synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] synonym: "L-glutamate(1-) import into cell" EXACT [] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0051938 ! L-glutamate import is_a: GO:0089718 ! amino acid import across plasma membrane created_by: mah creation_date: 2013-06-12T12:32:47Z [Term] id: GO:0098713 name: leucine import across plasma membrane namespace: biological_process alt_id: GO:1990122 def: "The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "L-leucine import into cell" NARROW [GOC:mah] synonym: "leucine import into cell" EXACT [] is_a: GO:0015820 ! leucine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport created_by: mah creation_date: 2013-06-12T12:27:47Z [Term] id: GO:0098714 name: malate import across plasma membrane namespace: biological_process alt_id: GO:0097405 def: "The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "malate import into cell" EXACT [] is_a: GO:0071423 ! malate transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: paola creation_date: 2012-10-29T11:18:48Z [Term] id: GO:0098715 name: malonic acid import across plasma membrane namespace: biological_process alt_id: GO:0097406 def: "The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "malonate import into cell" EXACT [] synonym: "malonic acid import into cell" EXACT [] is_a: GO:0098739 ! import across plasma membrane is_a: GO:1901553 ! malonic acid transmembrane transport created_by: paola creation_date: 2012-10-30T15:33:37Z [Term] id: GO:0098716 name: nickel cation import across plasma membrane namespace: biological_process alt_id: GO:0090509 def: "The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "nickel cation import into cell" EXACT [] is_a: GO:0035444 ! nickel cation transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: tanyaberardini creation_date: 2012-11-16T16:12:53Z [Term] id: GO:0098717 name: pantothenate import across plasma membrane namespace: biological_process alt_id: GO:0044755 alt_id: GO:1901688 def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "pantothenate import" RELATED [] synonym: "pantothenate import into cell" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:0098739 ! import across plasma membrane is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: jl creation_date: 2012-12-06T13:02:23Z [Term] id: GO:0098718 name: serine import across plasma membrane namespace: biological_process alt_id: GO:0061491 def: "The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "serine import into cell" EXACT [] is_a: GO:0032329 ! serine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport created_by: dph creation_date: 2012-12-06T14:55:29Z [Term] id: GO:0098719 name: sodium ion import across plasma membrane namespace: biological_process alt_id: GO:0097369 alt_id: GO:1990118 def: "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "sodium import" EXACT [] synonym: "sodium ion import" RELATED [] synonym: "sodium ion import into cell" EXACT [] is_a: GO:0035725 ! sodium ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: pr creation_date: 2012-08-03T16:55:52Z [Term] id: GO:0098720 name: succinate import across plasma membrane namespace: biological_process alt_id: GO:0097404 def: "The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "succinate import into cell" EXACT [] is_a: GO:0071422 ! succinate transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: paola creation_date: 2012-10-29T11:17:44Z [Term] id: GO:0098721 name: uracil import across plasma membrane namespace: biological_process alt_id: GO:1902431 def: "The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "uracil import into cell" EXACT [] is_a: GO:0098739 ! import across plasma membrane is_a: GO:1903791 ! uracil transmembrane transport created_by: tb creation_date: 2013-09-27T17:54:23Z [Term] id: GO:0098722 name: asymmetric stem cell division namespace: biological_process def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0017145 ! stem cell division [Term] id: GO:0098723 name: skeletal muscle myofibril namespace: cellular_component def: "A myofibril of a skeletal muscle fiber." [GOC:dos] is_a: GO:0030016 ! myofibril [Term] id: GO:0098724 name: symmetric stem cell division namespace: biological_process def: "Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population." [PMID:19948499, PMID:23303905] comment: Examples include the self-renewal of spermatogonial stem cells and (some) division during amplification of skeletal muscle satellite cell populations. is_a: GO:0017145 ! stem cell division is_a: GO:0098725 ! symmetric cell division [Term] id: GO:0098725 name: symmetric cell division namespace: biological_process def: "Cell division in which both daughter cells are of the same type." [GOC:dos] is_a: GO:0051301 ! cell division [Term] id: GO:0098726 name: symmetric division of skeletal muscle satellite stem cell namespace: biological_process def: "The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells. This process is involved in amplification of the pool of these cells." [PMID:23303905] is_a: GO:0098724 ! symmetric stem cell division [Term] id: GO:0098727 name: maintenance of cell number namespace: biological_process def: "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos] is_a: GO:0032502 ! developmental process [Term] id: GO:0098728 name: germline stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] is_a: GO:0042078 ! germ-line stem cell division is_a: GO:0098722 ! asymmetric stem cell division [Term] id: GO:0098729 name: germline stem cell symmetric division namespace: biological_process def: "Division of a germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:dos, PMID:19948499] is_a: GO:0042078 ! germ-line stem cell division is_a: GO:0098724 ! symmetric stem cell division [Term] id: GO:0098730 name: male germline stem cell symmetric division namespace: biological_process def: "The symmetric division of a male germline stem cell to produce two male germline stem cells. An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic." [GOC:dos, PMID:19948499] is_a: GO:0098729 ! germline stem cell symmetric division [Term] id: GO:0098731 name: skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells." [PMID:23303905] is_a: GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration is_a: GO:0035019 ! somatic stem cell population maintenance [Term] id: GO:0098732 name: macromolecule deacylation namespace: biological_process def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule." [GOC:dos] is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0098733 name: hemidesmosome associated protein complex namespace: cellular_component def: "Any protein complex that is part of or has some part in a hemidesmosome." [GOC:dos] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0098734 name: macromolecule depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a macromolecule." [GOC:dos] is_a: GO:0098732 ! macromolecule deacylation [Term] id: GO:0098735 name: positive regulation of the force of heart contraction namespace: biological_process def: "Any process that increases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0098736 name: negative regulation of the force of heart contraction namespace: biological_process def: "Any process that decreases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0098737 name: protein insertion into plasma membrane namespace: biological_process def: "The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:DOS] is_a: GO:0051205 ! protein insertion into membrane is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0098739 name: import across plasma membrane namespace: biological_process def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0098657 ! import into cell [Term] id: GO:0098740 name: multi organism cell adhesion namespace: biological_process def: "Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms." [GOC:dos] is_a: GO:0007155 ! cell adhesion is_a: GO:0051704 ! multi-organism process [Term] id: GO:0098741 name: adhesion between unicellular organisms via cell-wall interaction namespace: biological_process def: "The attachment of two unicellular organisms to each other via interaction between cell-wall components." [GOC:dos] is_a: GO:0098610 ! adhesion between unicellular organisms [Term] id: GO:0098742 name: cell-cell adhesion via plasma-membrane adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos] is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0098743 name: cell aggregation namespace: biological_process def: "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos] is_a: GO:0008150 ! biological_process [Term] id: GO:0098744 name: 1-phosphatidylinositol 4-kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of 1-phosphatidylinositol 4-kinase." [PMID:21288895] is_a: GO:0019209 ! kinase activator activity [Term] id: GO:0098745 name: Dcp1-Dcp2 complex namespace: cellular_component def: "A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA." [GOC:dos, GOC:vw, PMID:22323607] comment: Additional components may be present, for example in ascomycetes this complex includes an additional regulatory subunit, Edc1. is_a: GO:0005845 ! mRNA cap binding complex [Term] id: GO:0098746 name: fast, calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release." [GOC:dos, GOC:pad, GOC:PARL, PMID:4405553, PMID:7809151, PMID:7954835] synonym: "synchronous, calcium ion-dependent exocytosis of neurotransmitter" EXACT [PMID:7954835] is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter [Term] id: GO:0098747 name: slow, calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release." [GOC:dos, GOC:pad, GOC:parl, PMID:7809151, PMID:7954835] is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter [Term] id: GO:0098749 name: cerebellar neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0098750 name: FYXD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FXYD domain." [GOC:dos, GOC:mr, PMID:10950925, PMID:16403837, PMID:18000745] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0098751 name: bone cell development namespace: biological_process def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. subset: gocheck_do_not_annotate is_a: GO:0048468 ! cell development relationship: part_of GO:0060348 ! bone development [Term] id: GO:0098752 name: integral component of the cytoplasmic side of the plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos] is_a: GO:0005887 ! integral component of plasma membrane is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0098753 name: anchored component of the cytoplasmic side of the plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane." [GOC:dos] comment: Examples include many myristoylated proteins. is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane is_a: GO:0046658 ! anchored component of plasma membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0098754 name: detoxification namespace: biological_process def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] subset: goslim_pombe is_a: GO:0008150 ! biological_process relationship: part_of GO:0009636 ! response to toxic substance [Term] id: GO:0098755 name: maintenance of seed dormancy by absisic acid namespace: biological_process def: "The process by which seed dormancy is maintained by the presence of absisic acid." [GOC:dos, PMID:9580097] is_a: GO:0010231 ! maintenance of seed dormancy intersection_of: GO:0010231 ! maintenance of seed dormancy intersection_of: part_of GO:0009737 ! response to abscisic acid relationship: part_of GO:0009737 ! response to abscisic acid [Term] id: GO:0098756 name: response to interleukin-21 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah] synonym: "response to IL-21" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine [Term] id: GO:0098757 name: cellular response to interleukin-21 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah] synonym: "cellular response to IL-21" EXACT [GOC:mah] is_a: GO:0098756 ! response to interleukin-21 [Term] id: GO:0098758 name: response to interleukin-8 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah] synonym: "response to IL-8" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine [Term] id: GO:0098759 name: cellular response to interleukin-8 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah] synonym: "cellular response to IL-8" EXACT [GOC:mah] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0098758 ! response to interleukin-8 [Term] id: GO:0098760 name: response to interleukin-7 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] synonym: "response to IL-7" EXACT [GOC:mah] is_a: GO:0034097 ! response to cytokine [Term] id: GO:0098761 name: cellular response to interleukin-7 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] synonym: "cellular response to IL-7" EXACT [GOC:mah] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:0098760 ! response to interleukin-7 [Term] id: GO:0098762 name: meiotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle relationship: happens_during GO:0051321 ! meiotic cell cycle [Term] id: GO:0098763 name: mitotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000278 ! mitotic cell cycle [Term] id: GO:0098764 name: meiosis I cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098765 name: meiosis II cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098766 name: obsolete meiosis I M phase namespace: biological_process def: "OBSOLETE. M phase during meiosis I." [GOC:dos] comment: Obsoleted because added in error. is_obsolete: true consider: GO:0098762 [Term] id: GO:0098767 name: obsolete meiosis II M phase namespace: biological_process def: "OBSOLETE. M phase during meiosis II" [GOC:dos] comment: Obsoleted because added in error. is_obsolete: true consider: GO:0098762 [Term] id: GO:0098768 name: meiotic prometaphase I namespace: biological_process def: "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate." [PMID:16012859] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0098769 name: TIMP family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family" [PMID:22078297] is_a: GO:0005515 ! protein binding [Term] id: GO:0098770 name: FBXO family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction." [PMID:11178263] is_a: GO:0005515 ! protein binding [Term] id: GO:0098771 name: inorganic ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos] is_a: GO:0050801 ! ion homeostasis [Term] id: GO:0098772 name: molecular function regulator namespace: molecular_function def: "A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators." [GOC:dos, GOC:pt] subset: goslim_flybase_ribbon is_a: GO:0003674 ! molecular_function relationship: part_of GO:0065009 ! regulation of molecular function [Term] id: GO:0098773 name: skin epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos] is_a: GO:0008544 ! epidermis development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043588 ! skin development [Term] id: GO:0098774 name: curli namespace: cellular_component def: "A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization." [PMID:16704339] synonym: "tafi" NARROW [PMID:16704339] synonym: "thin aggregative fimbrae" NARROW [PMID:16704339] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0097311 ! bacterial biofilm matrix [Term] id: GO:0098775 name: curli assembly namespace: biological_process def: "The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex." [PMID:16704339] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0098776 name: protein transport across the cell outer membrane namespace: biological_process def: "The directed movement of proteins across the cell outer membrane." [GOC:dos] is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0098777 name: protein secretion by the type VIII secretion system namespace: biological_process def: "Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits." [PMID:19299134, PMID:24080089] comment: This term is defined so as to leave open the possibility that things other than curli subunits are secreted via same secretory system as that used by curli subunits. synonym: "T8SS" EXACT [PMID:19299134] is_a: GO:0098776 ! protein transport across the cell outer membrane [Term] id: GO:0098778 name: curli subunit secretion coupled to curli assembly namespace: biological_process def: "The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface." [PMID:24080089] synonym: "extracellular nucleation-precipitation pathway" EXACT [PMID:19299134] is_a: GO:0098777 ! protein secretion by the type VIII secretion system [Term] id: GO:0098779 name: positive regulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GOC:PARL, PMID:18200046, PMID:23985961] synonym: "positive regulation of macromitophagy in response to mitochondrial depolarization" EXACT [] is_a: GO:1901526 ! positive regulation of mitophagy is_a: GO:1904925 ! positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization intersection_of: GO:0098780 ! response to mitochondrial depolarisation intersection_of: positively_regulates GO:0000423 ! mitophagy [Term] id: GO:0098780 name: response to mitochondrial depolarisation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria." [GOC:dos] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0098781 name: ncRNA transcription namespace: biological_process def: "The transcription of non (protein) coding RNA from a DNA template." [GOC:dos] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0098782 name: mechanosensitived potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress." [PMID:22282805, PMID:25471887, PMID:25500157] synonym: "mechanically-gated potassium channel activity" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0140135 ! mechanosensitive cation channel activity [Term] id: GO:0098783 name: repair of mitotic merotelic kinetochore attachment defect namespace: biological_process def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with mitotic spindle microtubules emanating from both spindle poles (otherwise known as merotelic attachment to the spindle)." [PMID:21306900] synonym: "correction of merotelic kinetochore attachment, mitotic" EXACT [] synonym: "repair of mitotic merotelic kinetochore attachment defects" EXACT [] is_a: GO:1990598 ! repair of mitotic mono-orientation defect [Term] id: GO:0098784 name: biofilm matrix organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah] synonym: "biofilm matrix organization and biogenesis" RELATED [GOC:dos] is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0098785 name: biofilm matrix assembly namespace: biological_process def: "A process that results in the assembly of a biofilm matrix." [GOC:mah] is_a: GO:0085029 ! extracellular matrix assembly is_a: GO:0098784 ! biofilm matrix organization relationship: part_of GO:0042710 ! biofilm formation [Term] id: GO:0098786 name: biofilm matrix disassembly namespace: biological_process def: "A process that results in the disassembly of a biofilm matrix." [GOC:mah] is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0098784 ! biofilm matrix organization [Term] id: GO:0098787 name: mRNA cleavage involved in mRNA processing namespace: biological_process def: "Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide." [GOC:dos] is_a: GO:0006379 ! mRNA cleavage intersection_of: GO:0006379 ! mRNA cleavage intersection_of: part_of GO:0006397 ! mRNA processing relationship: part_of GO:0006397 ! mRNA processing [Term] id: GO:0098788 name: dendritic knob namespace: cellular_component def: "The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium." [PMID:20801626] synonym: "apical dendritic knob" EXACT [] is_a: GO:0044292 ! dendrite terminus [Term] id: GO:0098789 name: pre-mRNA cleavage required for polyadenylation namespace: biological_process def: "The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "pre-mRNA cleavage factor activity" EXACT [] is_a: GO:0098787 ! mRNA cleavage involved in mRNA processing relationship: has_part GO:0004521 ! endoribonuclease activity relationship: part_of GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0098790 name: ncRNA transcription associated with protein coding gene TSS/TES namespace: biological_process def: "The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes." [PMID:20502517] synonym: "pasRNA transcription" NARROW [PMID:20502517] is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0098791 name: Golgi subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi Apparatus." [GOC:dos] is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0031984 ! organelle subcompartment intersection_of: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus [Term] id: GO:0098792 name: xenophagy namespace: biological_process def: "The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents." [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060] comment: While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation. is_a: GO:0061912 ! selective autophagy relationship: part_of GO:0098542 ! defense response to other organism [Term] id: GO:0098793 name: presynapse namespace: cellular_component def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos] subset: goslim_synapse synonym: "presynaptic terminal" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045202 ! synapse [Term] id: GO:0098794 name: postsynapse namespace: cellular_component def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045202 ! synapse [Term] id: GO:0098795 name: mRNA cleavage involved in gene silencing namespace: biological_process def: "Cleavage of an mRNA occurring as part of the mechanism of gene silencing." [GOC:BHF, GOC:BHF_miRNA, GOC:dos] is_a: GO:0006379 ! mRNA cleavage intersection_of: GO:0006379 ! mRNA cleavage intersection_of: part_of GO:0016458 ! gene silencing relationship: part_of GO:0016458 ! gene silencing [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0098798 name: mitochondrial protein complex namespace: cellular_component def: "A protein complex that is part of a mitochondrion." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion [Term] id: GO:0098799 name: outer mitochondrial membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005741 ! mitochondrial outer membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0098800 name: inner mitochondrial membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0098801 name: regulation of renal system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003014 ! renal system process relationship: regulates GO:0003014 ! renal system process [Term] id: GO:0098802 name: plasma membrane signaling receptor complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0043235 ! receptor complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0098803 name: respiratory chain complex namespace: cellular_component def: "Any protein complex that is part of a respiratory chain" [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0070469 ! respirasome relationship: part_of GO:0070469 ! respirasome [Term] id: GO:0098804 name: non-motile cilium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a non-motile cilium." [GOC:cilia, GOC:dos] synonym: "nonmotile primary cilium membrane" RELATED [] is_a: GO:0060170 ! ciliary membrane [Term] id: GO:0098805 name: whole membrane namespace: cellular_component def: "Any lipid bilayer that completely encloses some structure, and all the proteins embedded in it or attached to it. Examples include the plasma membrane and most organelle membranes." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0016020 ! membrane [Term] id: GO:0098806 name: deadenylation involved in gene silencing by miRNA namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA following miRNA binding to mRNA, resulting in destabilization of the mRNA and a reduction in the efficiency of its translation." [GOC:BHF, GOC:dos, PMID:21118121, PMID:23209154] is_a: GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening intersection_of: GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening intersection_of: part_of GO:0035195 ! gene silencing by miRNA relationship: part_of GO:0035195 ! gene silencing by miRNA [Term] id: GO:0098807 name: chloroplast thylakoid membrane protein complex namespace: cellular_component def: "A protein complex that is part of a chloroplast thylakoid membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: part_of GO:0009535 ! chloroplast thylakoid membrane relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0098808 name: mRNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule." [GOC:dos] is_a: GO:0000339 ! RNA cap binding is_a: GO:0003729 ! mRNA binding [Term] id: GO:0098809 name: nitrite reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor." [GOC:dos, GOC:jh] is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0098810 name: neurotransmitter reuptake namespace: biological_process def: "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0001504 ! neurotransmitter uptake relationship: occurs_in GO:0098793 ! presynapse [Term] id: GO:0098811 name: obsolete transcriptional repressor activity, RNA polymerase II activating transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription." [GOC:BHF, GOC:dos, GOC:rl, GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II activating transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT [] synonym: "RNA polymerase II activating transcription factor binding transcription repressor activity" EXACT [] synonym: "RNA polymerase II transcription repressor activity" BROAD [] is_obsolete: true consider: GO:0001102 consider: GO:0001227 created_by: kchris creation_date: 2011-08-25T02:12:30Z [Term] id: GO:0098812 name: nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process namespace: biological_process def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus." [GOC:dph, GOC:jl, GOC:tb] synonym: "nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0043630 ! ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process relationship: part_of GO:0071035 ! nuclear polyadenylation-dependent rRNA catabolic process [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process [Term] id: GO:0098814 name: spontaneous synaptic transmission namespace: biological_process def: "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential." [PMID:20200227] comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs). subset: goslim_synapse synonym: "basal synaptic transmission" EXACT [PMID:16899074] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: has_part GO:0061669 ! spontaneous neurotransmitter secretion relationship: has_part GO:0061669 ! spontaneous neurotransmitter secretion [Term] id: GO:0098815 name: modulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0060079 ! excitatory postsynaptic potential relationship: regulates GO:0060079 ! excitatory postsynaptic potential [Term] id: GO:0098816 name: mini excitatory postsynaptic potential namespace: biological_process def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:dos] is_a: GO:0060079 ! excitatory postsynaptic potential [Term] id: GO:0098817 name: evoked excitatory postsynaptic potential namespace: biological_process def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse." [GOC:dos] is_a: GO:0060079 ! excitatory postsynaptic potential [Term] id: GO:0098818 name: hyperpolarization of postsynaptic membrane namespace: biological_process def: "A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold." [GOC:dos] is_a: GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0098819 name: depolarization of postsynaptic membrane namespace: biological_process def: "A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold." [GOC:dos] is_a: GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0098820 name: trans-synaptic protein complex namespace: cellular_component def: "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes." [PMID:20200227] subset: goslim_synapse is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0098821 name: BMP receptor activity namespace: molecular_function def: "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity." [GOC:BHF, GOC:dos] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity relationship: part_of GO:0030509 ! BMP signaling pathway [Term] id: GO:0098822 name: peptidyl-cysteine modification to L-cysteine persulfide namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide." [PMID:11592406] xref: RESID:AA0269 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0098823 name: peptidyl-cysteine modification to S-amindino-L-cysteine namespace: biological_process def: "The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] xref: RESID:AA0335 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0098824 name: peptidyl-cysteine sulfation namespace: biological_process def: "The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] xref: RESID:AA0171 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0098825 name: peptidyl-histidine guanylation namespace: biological_process def: "The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] xref: RESID:AA0325 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0098826 name: endoplasmic reticulum tubular network membrane namespace: cellular_component def: "The membrane of the endoplasmic reticulum tubular network." [PMID:16469703] is_a: GO:0016020 ! membrane [Term] id: GO:0098827 name: endoplasmic reticulum subcompartment namespace: cellular_component def: "A distinct region of the endoplasmic reticulum" [GOC:dos] is_a: GO:0031984 ! organelle subcompartment intersection_of: GO:0031984 ! organelle subcompartment intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum [Term] id: GO:0098828 name: modulation of inhibitory postsynaptic potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dos] synonym: "regulation of inhibitory postsynaptic potential" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0060080 ! inhibitory postsynaptic potential relationship: regulates GO:0060080 ! inhibitory postsynaptic potential [Term] id: GO:0098829 name: intestinal folate absorption namespace: biological_process def: "Uptake of folic into the blood by absorption from the small intestine." [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432] is_a: GO:0015884 ! folic acid transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0098830 name: presynaptic endosome namespace: cellular_component def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282] comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details. subset: goslim_synapse is_a: GO:0005768 ! endosome relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0098831 name: presynaptic active zone cytoplasmic component namespace: cellular_component def: "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos] subset: goslim_synapse synonym: "cortex of presynaptic active zone" EXACT [] synonym: "presynaptic zone cortex" EXACT [] is_a: GO:0099738 ! cell cortex region relationship: part_of GO:0048786 ! presynaptic active zone [Term] id: GO:0098832 name: peri-centrosomal recycling endosome namespace: cellular_component def: "A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes." [PMID:19696797, PMID:20820847] is_a: GO:0055037 ! recycling endosome [Term] id: GO:0098833 name: presynaptic endocytic zone namespace: cellular_component def: "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288] comment: May be identical to periactive zone? subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0098834 name: presynaptic endocytic zone cytoplasmic component namespace: cellular_component def: "The cytoplasmic component of the presynaptic endocytic zone." [GOC:dos] subset: goslim_synapse synonym: "cortex of presynaptic endocytic zone" EXACT [] is_a: GO:0099738 ! cell cortex region relationship: part_of GO:0098833 ! presynaptic endocytic zone [Term] id: GO:0098835 name: presynaptic endocytic zone membrane namespace: cellular_component def: "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos] subset: goslim_synapse is_a: GO:0097060 ! synaptic membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0042734 ! presynaptic membrane intersection_of: part_of GO:0098833 ! presynaptic endocytic zone relationship: part_of GO:0042734 ! presynaptic membrane relationship: part_of GO:0098833 ! presynaptic endocytic zone [Term] id: GO:0098836 name: cytoskeleton of dendritic spine namespace: cellular_component def: "The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling." [PMID:24854120] is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0043197 ! dendritic spine relationship: part_of GO:0043197 ! dendritic spine [Term] id: GO:0098837 name: postsynaptic recycling endosome namespace: cellular_component def: "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation." [PMID:20820847] subset: goslim_synapse synonym: "postsynaptic endosomal recycling compartment" BROAD [PMID:20820847] synonym: "postsynaptic recycling outpost" EXACT [PMID:20820847] is_a: GO:0055037 ! recycling endosome is_a: GO:0098845 ! postsynaptic endosome intersection_of: GO:0055037 ! recycling endosome intersection_of: part_of GO:0098794 ! postsynapse [Term] id: GO:0098838 name: folate transmembrane transport namespace: biological_process def: "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane." [PMID:24745983] comment: Changed term label, see https://github.com/geneontology/go-ontology/issues/15461 synonym: "folic acid transmembrane transport" RELATED [] synonym: "reduced folate transmembrane transport" NARROW [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015884 ! folic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0098839 name: postsynaptic density membrane namespace: cellular_component def: "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] subset: goslim_synapse is_a: GO:0099634 ! postsynaptic specialization membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0014069 ! postsynaptic density intersection_of: part_of GO:0045211 ! postsynaptic membrane relationship: part_of GO:0014069 ! postsynaptic density [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport [Term] id: GO:0098841 name: protein localization to cell division site after cytokinesis namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis." [PMID:25411334] is_a: GO:0072741 ! protein localization to cell division site [Term] id: GO:0098842 name: postsynaptic early endosome namespace: cellular_component def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling." [PMID:19603039, PMID:20820847, PMID:24727350] comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1. subset: goslim_synapse is_a: GO:0005769 ! early endosome is_a: GO:0098845 ! postsynaptic endosome intersection_of: GO:0005769 ! early endosome intersection_of: part_of GO:0098794 ! postsynapse [Term] id: GO:0098843 name: postsynaptic endocytic zone namespace: cellular_component def: "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0030118 ! clathrin coat relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0098844 name: postsynaptic endocytic zone membrane namespace: cellular_component def: "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta." [PMID:17880892] subset: goslim_synapse is_a: GO:0097060 ! synaptic membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane intersection_of: part_of GO:0098843 ! postsynaptic endocytic zone relationship: part_of GO:0045211 ! postsynaptic membrane relationship: part_of GO:0098843 ! postsynaptic endocytic zone [Term] id: GO:0098845 name: postsynaptic endosome namespace: cellular_component def: "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse." [PMID:20820847] subset: goslim_synapse is_a: GO:0005768 ! endosome intersection_of: GO:0005768 ! endosome intersection_of: part_of GO:0098794 ! postsynapse relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0098846 name: podocyte foot namespace: cellular_component def: "A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms." [PMID:25324828] synonym: "pedicel" EXACT [Wikipedia:Podocyte] synonym: "podocyte foot process" EXACT [PMID:25324828] synonym: "secondary podocyte projection" EXACT [] xref: Wikipedia:Podocyte is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0098847 name: sequence-specific single stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with single-stranded DNA of a specific nucleotide composition." [PMID:9531483] is_a: GO:0003697 ! single-stranded DNA binding is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0098848 name: alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik] synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" EXACT [EC:4.7.1.1] xref: EC:4.7.1.1 is_a: GO:0018835 ! carbon phosphorus lyase activity [Term] id: GO:0098849 name: cellular detoxification of cadmium ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw] is_a: GO:0071585 ! detoxification of cadmium ion is_a: GO:1990748 ! cellular detoxification relationship: part_of GO:0071276 ! cellular response to cadmium ion [Term] id: GO:0098850 name: extrinsic component of synaptic vesicle membrane namespace: cellular_component def: "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] subset: goslim_synapse is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0030672 ! synaptic vesicle membrane relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0098851 name: double-stranded miRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19966796] synonym: "miRNA duplex binding" EXACT [] is_a: GO:0003725 ! double-stranded RNA binding [Term] id: GO:0098852 name: lytic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] is_a: GO:0005774 ! vacuolar membrane [Term] id: GO:0098853 name: endoplasmic reticulum-vacuole membrane contact site namespace: cellular_component def: "A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes." [GOC:dos, PMID:26283797] synonym: "endoplasmic reticulum-vacuole membrane contact site" EXACT [] synonym: "ER-vacuole membrane contact site" EXACT [] is_a: GO:0044232 ! organelle membrane contact site [Term] id: GO:0098854 name: podocyte primary projection namespace: cellular_component def: "A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot." [PMID:24309184, PMID:25324828] synonym: "glomerular visceral epithelial cell primary projection" EXACT [] synonym: "podocyte major process" EXACT [] synonym: "primary podocyte process" EXACT [] is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0098855 name: HCN channel complex namespace: cellular_component alt_id: GO:1990746 alt_id: GO:1990759 def: "A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353] synonym: "HCN1 channel complex" NARROW [] synonym: "HCN2 channel complex" NARROW [] synonym: "HCN3 channel complex" NARROW [] synonym: "HCN4 channel complex" NARROW [] synonym: "K/Na hyperpolarization-activated channel 3 complex" NARROW [] synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW [] synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW [] synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW [] synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT [] synonym: "potassium/sodium hyperpolarization-activated channel 3 complex" NARROW [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer" RELATED [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer" RELATED [] synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT [] is_a: GO:0008076 ! voltage-gated potassium channel complex [Term] id: GO:0098856 name: intestinal lipid absorption namespace: biological_process def: "Any process in which lipids are taken up from the contents of the intestine." [GOC:dos, GOC:sl, PMID:18768481] is_a: GO:0006869 ! lipid transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0098857 name: membrane microdomain namespace: cellular_component def: "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] is_a: GO:0098589 ! membrane region [Term] id: GO:0098858 name: actin-based cell projection namespace: cellular_component def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: has_part GO:0005884 ! actin filament [Term] id: GO:0098859 name: actin filament bundle of actin-based cell projection namespace: cellular_component def: "A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments." [PMID:12566431, PMID:15661519] is_a: GO:0097518 ! parallel actin filament bundle intersection_of: GO:0097518 ! parallel actin filament bundle intersection_of: part_of GO:0098858 ! actin-based cell projection relationship: part_of GO:0098858 ! actin-based cell projection [Term] id: GO:0098860 name: actin filament bundle of stereocilium namespace: cellular_component def: "A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane." [PMID:15661519] is_a: GO:0098859 ! actin filament bundle of actin-based cell projection intersection_of: GO:0097518 ! parallel actin filament bundle intersection_of: part_of GO:0032420 ! stereocilium relationship: part_of GO:0032420 ! stereocilium [Term] id: GO:0098861 name: actin filament bundle of filopodium namespace: cellular_component def: "A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex." [PMID:12566431] is_a: GO:0098859 ! actin filament bundle of actin-based cell projection intersection_of: GO:0097518 ! parallel actin filament bundle intersection_of: part_of GO:0030175 ! filopodium relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0098862 name: cluster of actin-based cell projections namespace: cellular_component def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0098858 ! actin-based cell projection [Term] id: GO:0098863 name: nuclear migration by microtubule mediated pushing forces namespace: biological_process def: "The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules." [GOC:vw, PMID:11309419, PMID:16611238] is_a: GO:0007097 ! nuclear migration is_a: GO:0099098 ! microtubule polymerization based movement is_a: GO:0099111 ! microtubule-based transport [Term] id: GO:0098864 name: modification by symbiont of host tight cell-cell junction namespace: biological_process def: "The process in which a symbiont organism effects a change in the structure or function of its host tight junction, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [PMID:24287273] is_a: GO:0044067 ! modification by symbiont of host intercellular junctions [Term] id: GO:0098865 name: modification by symbiont of host bicellular tight junctions namespace: biological_process def: "The process in which an organism effects a change in the structure or function of its host bicellular tight junctions, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet" [PMID:24287273] is_a: GO:0098864 ! modification by symbiont of host tight cell-cell junction [Term] id: GO:0098866 name: multivesicular body fusion to apical plasma membrane namespace: biological_process def: "The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell." [PMID:26459596] is_a: GO:0090174 ! organelle membrane fusion is_a: GO:0140029 ! exocytic process relationship: part_of GO:1990182 ! exosomal secretion [Term] id: GO:0098867 name: intramembranous bone growth namespace: biological_process def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686] is_a: GO:0098868 ! bone growth [Term] id: GO:0098868 name: bone growth namespace: biological_process def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos] is_a: GO:0035265 ! organ growth [Term] id: GO:0098869 name: cellular oxidant detoxification namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw] is_a: GO:1990748 ! cellular detoxification [Term] id: GO:0098870 name: action potential propagation namespace: biological_process def: "The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold." [GOC:dos] is_a: GO:0001508 ! action potential [Term] id: GO:0098871 name: postsynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a postsynapse" [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse [Term] id: GO:0098872 name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse." [GOC:dos] subset: goslim_synapse synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [] synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099583 ! neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration intersection_of: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration [Term] id: GO:0098873 name: neuronal action potential back-propagation namespace: biological_process def: "Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma." [GOC:dos] is_a: GO:0098870 ! action potential propagation [Term] id: GO:0098874 name: spike train namespace: biological_process alt_id: GO:0099603 def: "A series of sequential, propagated action potentials occurring in a single cell." [ISBN:978-0071390118] synonym: "burst of action potentials" EXACT [] synonym: "spike-train" EXACT [] is_a: GO:0042391 ! regulation of membrane potential relationship: has_part GO:0001508 ! action potential [Term] id: GO:0098875 name: epididymosome namespace: cellular_component def: "A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins." [GOC:dos, GOC:mg, PMID:23177142, PMID:26112475] is_a: GO:1990742 ! microvesicle [Term] id: GO:0098876 name: vesicle-mediated transport to the plasma membrane namespace: biological_process def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0098877 name: neurotransmitter receptor transport to plasma membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0098878 name: neurotransmitter receptor complex namespace: cellular_component def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos] is_a: GO:0098802 ! plasma membrane signaling receptor complex [Term] id: GO:0098879 name: structural constituent of postsynaptic specialization namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization." [GOC:dos] subset: goslim_synapse is_a: GO:0099186 ! structural constituent of postsynapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0099572 ! postsynaptic specialization intersection_of: part_of GO:0098880 ! maintenance of postsynaptic specialization structure relationship: occurs_in GO:0099572 ! postsynaptic specialization relationship: part_of GO:0098880 ! maintenance of postsynaptic specialization structure [Term] id: GO:0098880 name: maintenance of postsynaptic specialization structure namespace: biological_process def: "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization." [GOC:dos] subset: goslim_synapse is_a: GO:0097106 ! postsynaptic density organization is_a: GO:0099558 ! maintenance of synapse structure [Term] id: GO:0098881 name: exocytic insertion of neurotransmitter receptor to plasma membrane namespace: biological_process def: "The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion." [GOC:aruk, GOC:bc, PMID:19503082] subset: goslim_synapse synonym: "neurotransmitter receptor insertion" EXACT [] is_a: GO:0006904 ! vesicle docking involved in exocytosis is_a: GO:0090522 ! vesicle tethering involved in exocytosis relationship: part_of GO:0098877 ! neurotransmitter receptor transport to plasma membrane [Term] id: GO:0098882 name: structural constituent of presynaptic active zone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos] subset: goslim_synapse synonym: "structural constituent of active zone" EXACT syngo_official_label [] is_a: GO:0098918 ! structural constituent of synapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0048786 ! presynaptic active zone intersection_of: part_of GO:0048790 ! maintenance of presynaptic active zone structure relationship: occurs_in GO:0048786 ! presynaptic active zone relationship: part_of GO:0048790 ! maintenance of presynaptic active zone structure [Term] id: GO:0098883 name: synapse pruning namespace: biological_process def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190] subset: goslim_synapse synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716] synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020] synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190] synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0050808 ! synapse organization [Term] id: GO:0098884 name: postsynaptic neurotransmitter receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos] comment: Added parent as requested in https://github.com/geneontology/synapse/issues/230. subset: goslim_synapse synonym: "postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label [] is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:0099590 ! neurotransmitter receptor internalization is_a: GO:0140239 ! postsynaptic endocytosis [Term] id: GO:0098885 name: modification of postsynaptic actin cytoskeleton namespace: biological_process def: "Any process that modifies the structure of a postsynaptic actin cytoskeleton." [GOC:dos] comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. subset: goslim_synapse synonym: "postsynaptic actin cytoskeleton remodelling" EXACT [] is_a: GO:0099010 ! modification of postsynaptic structure [Term] id: GO:0098886 name: modification of dendritic spine namespace: biological_process def: "Any process that modifies the structure of a dendritic spine." [GOC:dos] comment: This class does not cover assembly or disassembly of dendritic spines, only the modification/remodelling of existing ones. is_a: GO:0099010 ! modification of postsynaptic structure [Term] id: GO:0098887 name: neurotransmitter receptor transport, endosome to postsynaptic membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD [] is_a: GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane is_a: GO:0099639 ! neurotransmitter receptor transport, endosome to plasma membrane [Term] id: GO:0098888 name: extrinsic component of presynaptic membrane namespace: cellular_component def: "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse synonym: "extrinsic component of presynaptic plasma membrane" EXACT [] is_a: GO:0099243 ! extrinsic component of synaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0042734 ! presynaptic membrane relationship: part_of GO:0042734 ! presynaptic membrane [Term] id: GO:0098889 name: intrinsic component of presynaptic membrane namespace: cellular_component def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to presynaptic membrane" NARROW [] is_a: GO:0099240 ! intrinsic component of synaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0042734 ! presynaptic membrane relationship: part_of GO:0042734 ! presynaptic membrane [Term] id: GO:0098890 name: extrinsic component of postsynaptic membrane namespace: cellular_component def: "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0099243 ! extrinsic component of synaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane relationship: part_of GO:0045211 ! postsynaptic membrane [Term] id: GO:0098891 name: extrinsic component of presynaptic active zone membrane namespace: cellular_component def: "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098888 ! extrinsic component of presynaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0048787 ! presynaptic active zone membrane relationship: part_of GO:0048787 ! presynaptic active zone membrane [Term] id: GO:0098892 name: extrinsic component of postsynaptic specialization membrane namespace: cellular_component def: "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098890 ! extrinsic component of postsynaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0099634 ! postsynaptic specialization membrane relationship: part_of GO:0099634 ! postsynaptic specialization membrane [Term] id: GO:0098893 name: extrinsic component of postsynaptic endocytic zone namespace: cellular_component def: "The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098890 ! extrinsic component of postsynaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098844 ! postsynaptic endocytic zone membrane relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane [Term] id: GO:0098894 name: extrinsic component of presynaptic endocytic zone membrane namespace: cellular_component def: "The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098888 ! extrinsic component of presynaptic membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098835 ! presynaptic endocytic zone membrane relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane [Term] id: GO:0098895 name: postsynaptic endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a postsynaptic endosome." [GOC:pz] subset: goslim_synapse is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0098845 ! postsynaptic endosome [Term] id: GO:0098896 name: postsynaptic early endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a postsynaptic early endosome." [GOC:pz] subset: goslim_synapse is_a: GO:0031901 ! early endosome membrane is_a: GO:0098895 ! postsynaptic endosome membrane relationship: part_of GO:0098842 ! postsynaptic early endosome [Term] id: GO:0098897 name: spine apparatus membrane namespace: cellular_component def: "The lipid bilayer surrounding the spine apparatus." [GOC:mah] subset: goslim_synapse is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0097444 ! spine apparatus [Term] id: GO:0098898 name: dense core granule lumen namespace: cellular_component def: "The volume enclosed by the dense core granule membrane." [GOC:dos] synonym: "dense core vesicle lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0031045 ! dense core granule relationship: part_of GO:0031045 ! dense core granule [Term] id: GO:0098899 name: spine apparatus lumen namespace: cellular_component def: "The volume enclosed by the spine apparatus membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0097444 ! spine apparatus relationship: part_of GO:0097444 ! spine apparatus [Term] id: GO:0098900 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0001508 ! action potential relationship: regulates GO:0001508 ! action potential [Term] id: GO:0098901 name: regulation of cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential relationship: regulates GO:0086001 ! cardiac muscle cell action potential [Term] id: GO:0098902 name: regulation of membrane depolarization during action potential namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086010 ! membrane depolarization during action potential relationship: regulates GO:0086010 ! membrane depolarization during action potential [Term] id: GO:0098903 name: regulation of membrane repolarization during action potential namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] is_a: GO:0060306 ! regulation of membrane repolarization is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086011 ! membrane repolarization during action potential relationship: regulates GO:0086011 ! membrane repolarization during action potential [Term] id: GO:0098904 name: regulation of AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086016 ! AV node cell action potential relationship: regulates GO:0086016 ! AV node cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098905 name: regulation of bundle of His cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of bundle of His cardiac muscle cell action potential" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086043 ! bundle of His cell action potential relationship: regulates GO:0086043 ! bundle of His cell action potential created_by: dph creation_date: 2011-11-15T12:01:18Z [Term] id: GO:0098906 name: regulation of Purkinje myocyte action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086017 ! Purkinje myocyte action potential relationship: regulates GO:0086017 ! Purkinje myocyte action potential created_by: tanyaberardini creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098907 name: regulation of SA node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086015 ! SA node cell action potential relationship: regulates GO:0086015 ! SA node cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0098908 name: regulation of neuronal action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0051969 ! regulation of transmission of nerve impulse is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0019228 ! neuronal action potential relationship: regulates GO:0019228 ! neuronal action potential [Term] id: GO:0098909 name: regulation of cardiac muscle cell action potential involved in regulation of contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0086004 ! regulation of cardiac muscle cell contraction intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential relationship: part_of GO:0086004 ! regulation of cardiac muscle cell contraction created_by: tanyaberardini creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0098910 name: regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086014 ! atrial cardiac muscle cell action potential relationship: regulates GO:0086014 ! atrial cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T08:49:13Z [Term] id: GO:0098911 name: regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086005 ! ventricular cardiac muscle cell action potential relationship: regulates GO:0086005 ! ventricular cardiac muscle cell action potential created_by: tanyaberardini creation_date: 2011-11-10T07:59:36Z [Term] id: GO:0098912 name: membrane depolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "atrial cardiac muscle cell depolarization" BROAD [GOC:dph, GOC:tb] synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086014 ! atrial cardiac muscle cell action potential relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential [Term] id: GO:0098913 name: membrane depolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0051899 ! membrane depolarization intersection_of: part_of GO:0086005 ! ventricular cardiac muscle cell action potential relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential [Term] id: GO:0098914 name: membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential is_a: GO:0099624 ! atrial cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086014 ! atrial cardiac muscle cell action potential relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential [Term] id: GO:0098915 name: membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential is_a: GO:0099625 ! ventricular cardiac muscle cell membrane repolarization intersection_of: GO:0086009 ! membrane repolarization intersection_of: part_of GO:0086005 ! ventricular cardiac muscle cell action potential relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential [Term] id: GO:0098916 name: anterograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft" [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0098917 name: retrograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft" [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0098918 name: structural constituent of synapse namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0045202 ! synapse intersection_of: part_of GO:0050808 ! synapse organization relationship: occurs_in GO:0045202 ! synapse relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0098919 name: structural constituent of postsynaptic density namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a postsynaptic density." [GOC:dos] subset: goslim_synapse is_a: GO:0098879 ! structural constituent of postsynaptic specialization intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0014069 ! postsynaptic density intersection_of: part_of GO:0099562 ! maintenance of postsynaptic density structure relationship: occurs_in GO:0014069 ! postsynaptic density relationship: part_of GO:0099562 ! maintenance of postsynaptic density structure [Term] id: GO:0098920 name: retrograde trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099541 ! trans-synaptic signaling by lipid [Term] id: GO:0098921 name: retrograde trans-synaptic signaling by endocannabinoid namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098920 ! retrograde trans-synaptic signaling by lipid is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid [Term] id: GO:0098922 name: extrinsic component of dense core granule membrane namespace: cellular_component def: "The component of the dense core granule membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0032127 ! dense core granule membrane relationship: part_of GO:0032127 ! dense core granule membrane [Term] id: GO:0098923 name: retrograde trans-synaptic signaling by soluble gas namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099543 ! trans-synaptic signaling by soluble gas [Term] id: GO:0098924 name: retrograde trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide [Term] id: GO:0098925 name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission [Term] id: GO:0098926 name: postsynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos] comment: Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts. subset: gocheck_do_not_manually_annotate subset: goslim_synapse synonym: "postsynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0099536 ! synaptic signaling [Term] id: GO:0098927 name: vesicle-mediated transport between endosomal compartments namespace: biological_process def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome." [GOC:dos, PMID:10930469] is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0098928 name: presynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] comment: Do not directly annotate. This term intended for grouping. Annotate to either a subclass or to some other subclass of signal transduction extended with has_start_location/occurs_in presynapse or one of its parts. Such extensions will result in automatic annotation to this term. subset: gocheck_do_not_manually_annotate subset: goslim_synapse synonym: "presynaptic signaling pathway" EXACT syngo_official_label [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0098929 name: extrinsic component of spine apparatus membrane namespace: cellular_component def: "The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] subset: goslim_synapse is_a: GO:0031312 ! extrinsic component of organelle membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098897 ! spine apparatus membrane relationship: part_of GO:0098897 ! spine apparatus membrane [Term] id: GO:0098930 name: axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" EXACT [] synonym: "axoplasmic transport" EXACT [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0008088 ! axo-dendritic transport relationship: occurs_in GO:0030424 ! axon [Term] id: GO:0098931 name: virion attachment to host cell flagellum namespace: biological_process def: "The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface." [GOC:dos, VZ:3949] xref: VZ:3949 is_a: GO:0019062 ! virion attachment to host cell [Term] id: GO:0098932 name: disruption by virus of host cell wall peptidoglycan during virus entry namespace: biological_process def: "A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry." [GOC:dos, VZ:3940] synonym: "catabolism of host cell wall peptidoglycan by virus" EXACT [] synonym: "degradation of host cell wall peptidoglycan by virus" EXACT [] synonym: "degradation of host peptidoglycans during virus entry" EXACT [VZ:3940] synonym: "disassembly by virus of host cell wall peptidoglycan" EXACT [] xref: VZ:3940 is_a: GO:0044661 ! disruption by virus of host cell is_a: GO:0052009 ! disruption by symbiont of host cell wall is_a: GO:0098994 ! disruption of host cell envelope during viral entry [Term] id: GO:0098933 name: disruption by symbiont of host cell envelope namespace: biological_process def: "The process by which a symbiont breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] is_a: GO:0052008 ! disruption by symbiont of host cellular component is_a: GO:0052020 ! modification by symbiont of host cell wall is_a: GO:0052339 ! disruption by organism of cell wall of other organism involved in symbiotic interaction [Term] id: GO:0098934 name: retrograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport relationship: occurs_in GO:0032839 ! dendrite cytoplasm [Term] id: GO:0098935 name: dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194] subset: goslim_synapse synonym: "dendrite cargo transport" EXACT [] is_a: GO:0008088 ! axo-dendritic transport relationship: occurs_in GO:0030425 ! dendrite [Term] id: GO:0098936 name: intrinsic component of postsynaptic membrane namespace: cellular_component def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic membrane" NARROW [] is_a: GO:0099240 ! intrinsic component of synaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane relationship: part_of GO:0045211 ! postsynaptic membrane [Term] id: GO:0098937 name: anterograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport relationship: occurs_in GO:0032839 ! dendrite cytoplasm [Term] id: GO:0098938 name: actin cytoskeleton of dendritic spine namespace: cellular_component def: "The actin cytoskeleton that is part of a dendritic spine." [GOC:dos] subset: goslim_synapse is_a: GO:0098836 ! cytoskeleton of dendritic spine is_a: GO:0098871 ! postsynaptic actin cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: part_of GO:0043197 ! dendritic spine [Term] id: GO:0098939 name: dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai] subset: goslim_synapse is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098935 ! dendritic transport relationship: occurs_in GO:0032839 ! dendrite cytoplasm [Term] id: GO:0098940 name: anterograde trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0098916 ! anterograde trans-synaptic signaling is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide [Term] id: GO:0098941 name: anterograde trans-synaptic signaling by trans-synaptic protein complex namespace: biological_process def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex." [GOC:dos] subset: goslim_synapse is_a: GO:0098916 ! anterograde trans-synaptic signaling is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex [Term] id: GO:0098942 name: retrograde trans-synaptic signaling by trans-synaptic protein complex namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex [Term] id: GO:0098943 name: neurotransmitter receptor transport, postsynaptic endosome to lysosome namespace: biological_process def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD [] is_a: GO:0007041 ! lysosomal transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0061462 ! protein localization to lysosome is_a: GO:0072666 ! establishment of protein localization to vacuole is_a: GO:0099637 ! neurotransmitter receptor transport [Term] id: GO:0098944 name: postsynaptic recycling endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a postsynaptic recycling endosome." [GOC:pz] subset: goslim_synapse is_a: GO:0098895 ! postsynaptic endosome membrane relationship: part_of GO:0098837 ! postsynaptic recycling endosome [Term] id: GO:0098945 name: intrinsic component of presynaptic active zone membrane namespace: cellular_component def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to presynaptic acive zone membrane" NARROW [] is_a: GO:0098889 ! intrinsic component of presynaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0048787 ! presynaptic active zone membrane relationship: part_of GO:0048787 ! presynaptic active zone membrane [Term] id: GO:0098946 name: intrinsic component of presynaptic endocytic zone membrane namespace: cellular_component def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to presynaptic acive zone membrane" NARROW [] is_a: GO:0098889 ! intrinsic component of presynaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098835 ! presynaptic endocytic zone membrane relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane [Term] id: GO:0098947 name: intrinsic component of postsynaptic endocytic zone membrane namespace: cellular_component def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic acive zone membrane" NARROW [] is_a: GO:0098936 ! intrinsic component of postsynaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098844 ! postsynaptic endocytic zone membrane relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane [Term] id: GO:0098948 name: intrinsic component of postsynaptic specialization membrane namespace: cellular_component def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic specialization membrane" NARROW [] is_a: GO:0098936 ! intrinsic component of postsynaptic membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0099634 ! postsynaptic specialization membrane relationship: part_of GO:0099634 ! postsynaptic specialization membrane [Term] id: GO:0098949 name: intrinsic component of postsynaptic endosome membrane namespace: cellular_component def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic endosome membrane" NARROW [] is_a: GO:0031302 ! intrinsic component of endosome membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098895 ! postsynaptic endosome membrane relationship: part_of GO:0098895 ! postsynaptic endosome membrane [Term] id: GO:0098950 name: intrinsic component of postsynaptic early endosome membrane namespace: cellular_component def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic early endosome membrane" NARROW [] is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098896 ! postsynaptic early endosome membrane relationship: part_of GO:0098896 ! postsynaptic early endosome membrane [Term] id: GO:0098951 name: intrinsic component of postsynaptic recycling endosome membrane namespace: cellular_component def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic recycling endosome membrane" EXACT [] is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098944 ! postsynaptic recycling endosome membrane relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane [Term] id: GO:0098952 name: intrinsic component of spine apparatus membrane namespace: cellular_component def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to spine apparatus membrane" EXACT [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098897 ! spine apparatus membrane relationship: part_of GO:0098897 ! spine apparatus membrane [Term] id: GO:0098953 name: receptor diffusion trapping namespace: biological_process def: "The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix." [PMID:18832033] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0051668 ! localization within membrane is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery relationship: occurs_in GO:0005886 ! plasma membrane [Term] id: GO:0098954 name: presynaptic endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a presynaptic endosome." [GOC:pz] subset: goslim_synapse is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0098830 ! presynaptic endosome [Term] id: GO:0098955 name: intrinsic component of presynaptic endosome membrane namespace: cellular_component def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to presynaptic endosome membrane" EXACT [] is_a: GO:0031302 ! intrinsic component of endosome membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098954 ! presynaptic endosome membrane relationship: part_of GO:0098954 ! presynaptic endosome membrane [Term] id: GO:0098956 name: intrinsic component of dense core granule membrane namespace: cellular_component def: "The component of the dense core granule membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to dense core granule membrane" EXACT [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0032127 ! dense core granule membrane relationship: part_of GO:0032127 ! dense core granule membrane [Term] id: GO:0098957 name: anterograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon transport of mitochondria" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion [Term] id: GO:0098958 name: retrograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde axon transport of mitochondria" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion [Term] id: GO:0098959 name: retrograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde dendrite transport of mitochondria" EXACT [] is_a: GO:0098939 ! dendritic transport of mitochondrion [Term] id: GO:0098960 name: postsynaptic neurotransmitter receptor activity namespace: molecular_function def: "Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling] synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission." EXACT [] is_a: GO:0030594 ! neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: part_of GO:0007268 ! chemical synaptic transmission relationship: occurs_in GO:0045211 ! postsynaptic membrane relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic [Term] id: GO:0098961 name: dendritic transport of ribonucleoprotein complex namespace: biological_process def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] subset: goslim_synapse synonym: "dendritic transport of RNP complex" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0050658 ! RNA transport is_a: GO:0098935 ! dendritic transport is_a: GO:0099640 ! axo-dendritic protein transport relationship: occurs_in GO:0032839 ! dendrite cytoplasm [Term] id: GO:0098962 name: regulation of postsynaptic neurotransmitter receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] subset: goslim_synapse is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099601 ! regulation of neurotransmitter receptor activity intersection_of: GO:0065009 ! regulation of molecular function intersection_of: regulates GO:0098960 ! postsynaptic neurotransmitter receptor activity relationship: regulates GO:0098960 ! postsynaptic neurotransmitter receptor activity [Term] id: GO:0098963 name: dendritic transport of messenger ribonucleoprotein complex namespace: biological_process def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] subset: goslim_synapse synonym: "dendritic transport of mRNA RNP complex" EXACT [] is_a: GO:0098961 ! dendritic transport of ribonucleoprotein complex [Term] id: GO:0098964 name: anterograde dendritic transport of messenger ribonucleoprotein complex namespace: biological_process def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] subset: goslim_synapse synonym: "anterograde dendritic transport of mRNA RNP complex" EXACT [] is_a: GO:0035418 ! protein localization to synapse is_a: GO:0098937 ! anterograde dendritic transport is_a: GO:0098963 ! dendritic transport of messenger ribonucleoprotein complex [Term] id: GO:0098965 name: extracellular matrix of synaptic cleft namespace: cellular_component def: "The portion of the extracellular matrix that lies within the synaptic cleft." [GOC:dos] subset: goslim_synapse synonym: "ECM of synaptic cleft" EXACT [] synonym: "synaptic cleft ECM" EXACT [] is_a: GO:0062023 ! collagen-containing extracellular matrix relationship: part_of GO:0043083 ! synaptic cleft relationship: part_of GO:0099535 ! synapse-associated extracellular matrix [Term] id: GO:0098966 name: perisynaptic extracellular matrix namespace: cellular_component def: "The portion of the extracellular matrix that lies within the perisynaptic space." [GOC:dos] subset: goslim_synapse synonym: "extrasynaptic extracellular matrix" EXACT [] synonym: "perisynaptic ECM" EXACT [] is_a: GO:0062023 ! collagen-containing extracellular matrix relationship: part_of GO:0099535 ! synapse-associated extracellular matrix relationship: part_of GO:0099544 ! perisynaptic space [Term] id: GO:0098967 name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082] subset: goslim_synapse is_a: GO:0006887 ! exocytosis is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels intersection_of: GO:0006887 ! exocytosis intersection_of: part_of GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane relationship: part_of GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane [Term] id: GO:0098968 name: neurotransmitter receptor transport postsynaptic membrane to endosome namespace: biological_process def: "Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos] subset: goslim_synapse is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:1902946 ! protein localization to early endosome [Term] id: GO:0098969 name: neurotransmitter receptor transport to postsynaptic membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane [Term] id: GO:0098970 name: postsynaptic neurotransmitter receptor diffusion trapping namespace: biological_process def: "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization." [PMID:18832033] subset: goslim_synapse is_a: GO:0099628 ! neurotransmitter receptor diffusion trapping is_a: GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane relationship: occurs_in GO:0045211 ! postsynaptic membrane relationship: occurs_in GO:0099634 ! postsynaptic specialization membrane [Term] id: GO:0098971 name: anterograde dendritic transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098937 ! anterograde dendritic transport is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:0099640 ! axo-dendritic protein transport [Term] id: GO:0098972 name: anterograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098937 ! anterograde dendritic transport is_a: GO:0098939 ! dendritic transport of mitochondrion [Term] id: GO:0098973 name: structural constituent of postsynaptic actin cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0005200 ! structural constituent of cytoskeleton is_a: GO:0099186 ! structural constituent of postsynapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0098871 ! postsynaptic actin cytoskeleton intersection_of: part_of GO:0098974 ! postsynaptic actin cytoskeleton organization relationship: occurs_in GO:0098871 ! postsynaptic actin cytoskeleton relationship: part_of GO:0098974 ! postsynaptic actin cytoskeleton organization [Term] id: GO:0098974 name: postsynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization [Term] id: GO:0098975 name: postsynapse of neuromuscular junction namespace: cellular_component def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502] is_a: GO:0098794 ! postsynapse relationship: part_of GO:0031594 ! neuromuscular junction [Term] id: GO:0098976 name: excitatory chemical synaptic transmission namespace: biological_process def: "Synaptic transmission that results in an excitatory postsynaptic potential." [GOC:dos] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: has_part GO:0060079 ! excitatory postsynaptic potential relationship: has_part GO:0060079 ! excitatory postsynaptic potential [Term] id: GO:0098977 name: inhibitory chemical synaptic transmission namespace: biological_process def: "Synaptic transmission that results in an inhibitory postsynaptic potential." [GOC:dos] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: has_part GO:0060080 ! inhibitory postsynaptic potential relationship: has_part GO:0060080 ! inhibitory postsynaptic potential [Term] id: GO:0098978 name: glutamatergic synapse namespace: cellular_component def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse [Term] id: GO:0098979 name: polyadic synapse namespace: cellular_component def: "A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems." [PMID:26780543] is_a: GO:0045202 ! synapse [Term] id: GO:0098980 name: presynaptic density namespace: cellular_component def: "An electron dense specialization of the presynaptic active zone cytoskeleton." [GOC:dos, PMID:26780543] is_a: GO:0048788 ! cytoskeleton of presynaptic active zone [Term] id: GO:0098981 name: cholinergic synapse namespace: cellular_component def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse [Term] id: GO:0098982 name: GABA-ergic synapse namespace: cellular_component def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse [Term] id: GO:0098983 name: symmetric, GABA-ergic, inhibitory synapse namespace: cellular_component def: "A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials." [GOC:dos] is_a: GO:0032280 ! symmetric synapse is_a: GO:0060077 ! inhibitory synapse is_a: GO:0098982 ! GABA-ergic synapse [Term] id: GO:0098984 name: neuron to neuron synapse namespace: cellular_component def: "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] is_a: GO:0045202 ! synapse [Term] id: GO:0098985 name: asymmetric, glutamatergic, excitatory synapse namespace: cellular_component def: "A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials." [GOC:dos] is_a: GO:0032279 ! asymmetric synapse is_a: GO:0060076 ! excitatory synapse is_a: GO:0098978 ! glutamatergic synapse [Term] id: GO:0098986 name: T-bar namespace: cellular_component def: "A T-shaped presynpatic density. These are common in arhropod central nervous systems." [GOC:dos, PMID:26780543] is_a: GO:0098980 ! presynaptic density [Term] id: GO:0098987 name: regulation of modification of synapse structure, modulating synaptic transmission namespace: biological_process def: "Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:1905244 ! regulation of modification of synaptic structure intersection_of: GO:1905244 ! regulation of modification of synaptic structure intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0098988 name: G protein-coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos] synonym: "G-protein coupled glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0098989 name: NMDA selective glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005] is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway [Term] id: GO:0098990 name: AMPA selective glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005] subset: goslim_synapse is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway [Term] id: GO:0098991 name: kainate selective glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:9780071120005] subset: goslim_synapse is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway [Term] id: GO:0098992 name: neuronal dense core vesicle namespace: cellular_component def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] subset: goslim_synapse is_a: GO:0031045 ! dense core granule [Term] id: GO:0098993 name: anchored component of synaptic vesicle membrane namespace: cellular_component def: "The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0031225 ! anchored component of membrane is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0098994 name: disruption of host cell envelope during viral entry namespace: biological_process def: "The disruption of host cell envelope by viral proteins during virus entry" [GOC:dos] xref: VZ:3938 is_a: GO:0098933 ! disruption by symbiont of host cell envelope intersection_of: GO:0098933 ! disruption by symbiont of host cell envelope intersection_of: part_of GO:0046718 ! viral entry into host cell relationship: part_of GO:0046718 ! viral entry into host cell [Term] id: GO:0098995 name: disruption by virus of host envelope lipopolysaccharide during virus entry namespace: biological_process def: "The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides." [GOC:dos, VZ:3940] synonym: "degradation of host cell envelope lipopolysaccharide during viral entry" EXACT [] synonym: "degradation of host lipopolysaccharide during virus entry" EXACT [VZ:3940] synonym: "disassembly by virus of outer membrane lipopolysaccharide during viral entry" NARROW [] xref: VZ:3939 is_a: GO:0044661 ! disruption by virus of host cell is_a: GO:0052009 ! disruption by symbiont of host cell wall is_a: GO:0098994 ! disruption of host cell envelope during viral entry [Term] id: GO:0098996 name: disruption of host cell glycocalyx during viral entry namespace: biological_process def: "The disruption of host cell glycocalyx by viral proteins during virus entry" [GOC:dos] synonym: "catabolism of host glycocalyx during viral entry" EXACT [] synonym: "degradation of host capsule during virus entry" EXACT [VZ:3896] synonym: "degradation of host glycocalyx during viral entry" EXACT [] synonym: "disassembly of glycocalyx during viral entry" EXACT [] xref: VZ:3938 is_a: GO:0098994 ! disruption of host cell envelope during viral entry [Term] id: GO:0098997 name: fusion of virus membrane with host outer membrane namespace: biological_process def: "Fusion of a viral membrane with the host cell outer membrane during viral entry." [GOC:dos, VZ:3941] synonym: "fusion of viral membrane with host outer membrane" RELATED [GOC:dos, VZ:3941] synonym: "viral envelope fusion" BROAD [] synonym: "viral envelope fusion with host outer membrane" EXACT [] synonym: "viral penetration via membrane fusion" BROAD [] synonym: "viral-cell fusion molecule activity" RELATED [] xref: VZ:3941 "Fusion of virus membrane with host cell membrane" is_a: GO:0019064 ! fusion of virus membrane with host plasma membrane [Term] id: GO:0098998 name: extrinsic component of postsynaptic early endosome membrane namespace: cellular_component def: "The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098896 ! postsynaptic early endosome membrane relationship: part_of GO:0098896 ! postsynaptic early endosome membrane [Term] id: GO:0098999 name: extrinsic component of postsynaptic endosome membrane namespace: cellular_component def: "The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0031313 ! extrinsic component of endosome membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098895 ! postsynaptic endosome membrane relationship: part_of GO:0098895 ! postsynaptic endosome membrane [Term] id: GO:0099000 name: viral genome ejection through host cell envelope, contractile tail mechanism namespace: biological_process def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope." [GOC:dos, PMID:26283379, VZ:3950] synonym: "viral contractile tail ejection system" EXACT [VZ:3950] xref: VZ:3950 is_a: GO:0039678 ! viral genome ejection through host cell envelope [Term] id: GO:0099001 name: viral genome ejection through host cell envelope, long flexible tail mechanism namespace: biological_process def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm." [GOC:dos, PMID:22297512, VZ:3952] synonym: "viral long flexible tail ejection system" EXACT [VZ:3952] xref: VZ:3952 is_a: GO:0039678 ! viral genome ejection through host cell envelope is_a: GO:0046794 ! transport of virus [Term] id: GO:0099002 name: viral genome ejection through host cell envelope, short tail mechanism namespace: biological_process def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties." [GOC:dos, PMID:22297513, VZ:3954] synonym: "viral short tail ejection system" EXACT [VZ:3954] xref: VZ:3954 is_a: GO:0039678 ! viral genome ejection through host cell envelope is_a: GO:0046794 ! transport of virus [Term] id: GO:0099003 name: vesicle-mediated transport in synapse namespace: biological_process def: "Any vesicle-mediated transport that occurs in a synapse" [GOC:dos] subset: goslim_synapse is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse [Term] id: GO:0099004 name: calmodulin dependent kinase signaling pathway namespace: biological_process def: "Any signal transduction pathway involving calmodulin dependent kinase activity." [GOC:dos] synonym: "CAMK signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: has_part GO:0004683 ! calmodulin-dependent protein kinase activity relationship: has_part GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0099005 name: extrinsic component of postsynaptic recycling endosome membrane namespace: cellular_component def: "The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098944 ! postsynaptic recycling endosome membrane relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane [Term] id: GO:0099006 name: viral entry via permeabilization of endosomal membrane namespace: biological_process def: "The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen." [PMID:15329727, PMID:25055856, VZ:985] synonym: "viral penetration via permeabilization of host membrane" BROAD [vz:985] xref: VZ:985 is_a: GO:0140267 ! viral entry via permeabilization of host membrane [Term] id: GO:0099007 name: extrinsic component of presynaptic endosome membrane namespace: cellular_component def: "The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0031313 ! extrinsic component of endosome membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098954 ! presynaptic endosome membrane relationship: part_of GO:0098954 ! presynaptic endosome membrane [Term] id: GO:0099008 name: viral entry via permeabilization of inner membrane namespace: biological_process def: "The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane." [PMID:15795287, PMID:20427561, VZ:985] synonym: "viral penetration via permeabilization of host membrane" BROAD [vz:985] xref: VZ:985 is_a: GO:0140267 ! viral entry via permeabilization of host membrane [Term] id: GO:0099009 name: viral genome circularization namespace: biological_process def: "The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities" [PMID:11894948, PMID:15489417, PMID:19523475, PMID:319596, VZ:3968] xref: VZ:3968 is_a: GO:0016032 ! viral process [Term] id: GO:0099010 name: modification of postsynaptic structure namespace: biological_process def: "Any process that modifies the structure of a postsynapse." [GOC:dos] comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones. subset: goslim_synapse synonym: "synapse remodelling" BROAD [] is_a: GO:0099563 ! modification of synaptic structure [Term] id: GO:0099011 name: neuronal dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] is_a: GO:1990504 ! dense core granule exocytosis created_by: kmv [Term] id: GO:0099012 name: neuronal dense core vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] subset: goslim_synapse is_a: GO:0032127 ! dense core granule membrane relationship: part_of GO:0098992 ! neuronal dense core vesicle [Term] id: GO:0099013 name: neuronal dense core vesicle lumen namespace: cellular_component def: "The volume enclosed by a neuronal dense core vesicle membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098898 ! dense core granule lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0098992 ! neuronal dense core vesicle relationship: part_of GO:0098992 ! neuronal dense core vesicle [Term] id: GO:0099014 name: neuronal dense core vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] is_a: GO:0061109 ! dense core granule organization [Term] id: GO:0099015 name: degradation of host chromosome by virus namespace: biological_process def: "The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis." [PMID:163355, PMID:335083, PMID:3972821, PMID:5263754, VZ:3947] xref: VZ:3947 is_a: GO:0039637 ! catabolism by virus of host DNA [Term] id: GO:0099016 name: DNA end degradation evasion by virus namespace: biological_process def: "Any process, either active or passive, by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases." [GOC:dos, VZ:3963] xref: VZ:3963 is_a: GO:0019049 ! mitigation of host defenses by virus [Term] id: GO:0099017 name: maintenance of protein localization at cell tip namespace: biological_process def: "Any process in which localization of a protein is maintained at the cell tip." [GOC:dos, GOC:vw, PMID:12894167] synonym: "maintenance of protein location at cell tip" EXACT [] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0051286 ! cell tip relationship: occurs_in GO:0051286 ! cell tip property_value: http://purl.org/dc/elements/1.1/creator "dos" xsd:string property_value: http://purl.org/dc/elements/1.1/date 2016-06-30T15:17:41Z xsd:dateTime [Term] id: GO:0099018 name: restriction-modification system evasion by virus namespace: biological_process def: "Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction." [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966] xref: VZ:3966 is_a: GO:0019049 ! mitigation of host defenses by virus [Term] id: GO:0099019 name: maintenance of protein localization at growing cell tip namespace: biological_process def: "Any process in which localization of a protein is maintained at the growing cell tip." [GOC:dos, GOC:vw, PMID:24146635] synonym: "maintenance of protein location at growing cell tip" EXACT [] is_a: GO:0099017 ! maintenance of protein localization at cell tip intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0035838 ! growing cell tip relationship: occurs_in GO:0035838 ! growing cell tip created_by: dos creation_date: 2016-06-30T15:17:41Z [Term] id: GO:0099020 name: perinuclear endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the perinuclear endoplasmic reticulum." [GOC:dos, GOC:vw] is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0097038 ! perinuclear endoplasmic reticulum relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum [Term] id: GO:0099021 name: cortical endoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the cortical endoplasmic reticulum." [GOC:dos, GOC:vw] is_a: GO:0005788 ! endoplasmic reticulum lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0032541 ! cortical endoplasmic reticulum relationship: part_of GO:0032541 ! cortical endoplasmic reticulum [Term] id: GO:0099022 name: vesicle tethering namespace: biological_process def: "The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion." [PMID:27243008] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0006903 ! vesicle targeting [Term] id: GO:0099023 name: vesicle tethering complex namespace: cellular_component def: "Any protein complex that plays a role in vesicle tethering." [GOC:dos, GOC:vw, PMID:27243008] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0099024 name: plasma membrane invagination namespace: biological_process def: "An infolding of the plasma membrane." [GOC:dos, GOC:vw] is_a: GO:0010324 ! membrane invagination [Term] id: GO:0099025 name: anchored component of postsynaptic membrane namespace: cellular_component def: "The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098936 ! intrinsic component of postsynaptic membrane is_a: GO:0099144 ! anchored component of synaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane [Term] id: GO:0099026 name: anchored component of presynaptic membrane namespace: cellular_component def: "The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse synonym: "anchored component of presynaptic plasma membrane" EXACT [] is_a: GO:0098889 ! intrinsic component of presynaptic membrane is_a: GO:0099144 ! anchored component of synaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0042734 ! presynaptic membrane [Term] id: GO:0099027 name: anchored component of presynaptic endocytic zone membrane namespace: cellular_component def: "The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane is_a: GO:0099026 ! anchored component of presynaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098835 ! presynaptic endocytic zone membrane [Term] id: GO:0099028 name: anchored component of postynaptic endocytic zone membrane namespace: cellular_component def: "The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane is_a: GO:0099025 ! anchored component of postsynaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098844 ! postsynaptic endocytic zone membrane [Term] id: GO:0099029 name: anchored component of presynaptic active zone membrane namespace: cellular_component def: "The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane is_a: GO:0099026 ! anchored component of presynaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0048787 ! presynaptic active zone membrane [Term] id: GO:0099030 name: anchored component of postsynaptic specialization membrane namespace: cellular_component def: "The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane is_a: GO:0099025 ! anchored component of postsynaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0099634 ! postsynaptic specialization membrane [Term] id: GO:0099031 name: anchored component of postsynaptic density membrane namespace: cellular_component def: "The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098839 ! postsynaptic density membrane [Term] id: GO:0099032 name: anchored component of postsynaptic early endosome membrane namespace: cellular_component def: "The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098896 ! postsynaptic early endosome membrane [Term] id: GO:0099033 name: anchored component of postsynaptic recycling endosome membrane namespace: cellular_component def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098944 ! postsynaptic recycling endosome membrane [Term] id: GO:0099034 name: anchored component of postsynaptic endosome membrane namespace: cellular_component def: "The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0031225 ! anchored component of membrane is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098895 ! postsynaptic endosome membrane [Term] id: GO:0099035 name: anchored component of spine apparatus membrane namespace: cellular_component def: "The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0031225 ! anchored component of membrane is_a: GO:0098952 ! intrinsic component of spine apparatus membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098897 ! spine apparatus membrane [Term] id: GO:0099036 name: anchored component of neuronal dense core vesicle membrane namespace: cellular_component def: "The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0031225 ! anchored component of membrane is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0099012 ! neuronal dense core vesicle membrane [Term] id: GO:0099037 name: anchored component of presynaptic endosome membrane namespace: cellular_component def: "The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0031225 ! anchored component of membrane is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0098954 ! presynaptic endosome membrane [Term] id: GO:0099038 name: ceramide floppase activity namespace: molecular_function def: "Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:BHF, GOC:dos, GOC:rl] synonym: "ATP-dependent ceramide transporter activity" BROAD [] synonym: "ATPase-coupled ceramide transporter activity" BROAD [] synonym: "ceramide floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] synonym: "ceramide-translocating ATPase activity" BROAD [] is_a: GO:0046623 ! sphingolipid floppase activity relationship: part_of GO:0099040 ! ceramide translocation [Term] id: GO:0099039 name: sphingolipid translocation namespace: biological_process def: "The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl] is_a: GO:0034204 ! lipid translocation is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0099040 name: ceramide translocation namespace: biological_process def: "The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl] is_a: GO:0035627 ! ceramide transport is_a: GO:0099039 ! sphingolipid translocation [Term] id: GO:0099041 name: vesicle tethering to Golgi namespace: biological_process def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008] is_a: GO:0099022 ! vesicle tethering created_by: tanyaberardini creation_date: 2013-01-08T15:07:50Z [Term] id: GO:0099042 name: nucleation of clathrin-coated pit namespace: biological_process def: "The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit." [GOC:dos, GOC:vw, PMID:21779028] is_a: GO:0099024 ! plasma membrane invagination relationship: part_of GO:0072583 ! clathrin-dependent endocytosis [Term] id: GO:0099043 name: cargo loading involved in clathrin-dependent endocytosis namespace: biological_process def: "Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat." [GOC:dos, GOC:lb, GOC:vw, PMID:21779028] is_a: GO:0035652 ! clathrin-coated vesicle cargo loading intersection_of: GO:0035652 ! clathrin-coated vesicle cargo loading intersection_of: part_of GO:0072583 ! clathrin-dependent endocytosis relationship: part_of GO:0072583 ! clathrin-dependent endocytosis [Term] id: GO:0099044 name: vesicle tethering to endoplasmic reticulum namespace: biological_process def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008] is_a: GO:0099022 ! vesicle tethering created_by: tanyaberardini creation_date: 2013-01-08T15:07:50Z [Term] id: GO:0099045 name: viral extrusion namespace: biological_process def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:2024582831, VZ:3951] xref: VZ:3951 is_a: GO:0046753 ! non-lytic viral release [Term] id: GO:0099046 name: clearance of foreign intracellular nucleic acids namespace: biological_process def: "A defense process that protects an organism from invading foreign DNA or RNA." [GO:dos] is_a: GO:0006952 ! defense response [Term] id: GO:0099047 name: clearance of foreign intracellular RNA namespace: biological_process def: "A defense process that protects an organism from invading foreign RNA." [GO:dos] is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids [Term] id: GO:0099048 name: CRISPR-cas system namespace: biological_process def: "An adaptive immune response of bacteria that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci." [PMID:23495939] is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids [Term] id: GO:0099049 name: clathrin coat assembly involved in endocytosis namespace: biological_process def: "The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation." [PMID:21779028] is_a: GO:0048268 ! clathrin coat assembly relationship: part_of GO:0072583 ! clathrin-dependent endocytosis [Term] id: GO:0099050 name: vesicle scission namespace: biological_process def: "The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane." [PMID:21779028] is_a: GO:0090148 ! membrane fission [Term] id: GO:0099051 name: vesicle scission involved in endocytosis namespace: biological_process def: "The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane." [PMID:21779028] is_a: GO:0099050 ! vesicle scission intersection_of: GO:0099050 ! vesicle scission intersection_of: part_of GO:0006897 ! endocytosis relationship: part_of GO:0006897 ! endocytosis [Term] id: GO:0099052 name: vesicle scission involved in clathrin-mediated endocytosis namespace: biological_process def: "The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane." [PMID:21779028] comment: Like other vesicle scission events this involves dynamin. At least some of the dynamin recruiting factors are distinct to scission of clathrin-coated vesicles (PMID:21779028). is_a: GO:0099051 ! vesicle scission involved in endocytosis intersection_of: GO:0099050 ! vesicle scission intersection_of: part_of GO:0072583 ! clathrin-dependent endocytosis relationship: part_of GO:0072583 ! clathrin-dependent endocytosis [Term] id: GO:0099053 name: activating signal cointegrator 1 complex namespace: cellular_component def: "A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3." [PMID:12077347] synonym: "ASC-1 complex" EXACT [PMID:12077347] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0099054 name: presynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494] subset: goslim_synapse synonym: "presynapse biogenesis" EXACT [GOC:mah] synonym: "presynaptic terminal assembly" EXACT [PMID:24449494] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099172 ! presynapse organization relationship: part_of GO:0007416 ! synapse assembly [Term] id: GO:0099055 name: integral component of postsynaptic membrane namespace: cellular_component def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098936 ! intrinsic component of postsynaptic membrane is_a: GO:0099699 ! integral component of synaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane [Term] id: GO:0099056 name: integral component of presynaptic membrane namespace: cellular_component def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse synonym: "integral component of presynaptic plasma membrane" EXACT [] is_a: GO:0098889 ! intrinsic component of presynaptic membrane is_a: GO:0099699 ! integral component of synaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0042734 ! presynaptic membrane [Term] id: GO:0099057 name: integral component of presynaptic endocytic zone membrane namespace: cellular_component def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane is_a: GO:0099056 ! integral component of presynaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098835 ! presynaptic endocytic zone membrane [Term] id: GO:0099058 name: integral component of postsynaptic endocytic zone membrane namespace: cellular_component def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane is_a: GO:0099055 ! integral component of postsynaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098844 ! postsynaptic endocytic zone membrane [Term] id: GO:0099059 name: integral component of presynaptic active zone membrane namespace: cellular_component def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane is_a: GO:0099056 ! integral component of presynaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0048787 ! presynaptic active zone membrane [Term] id: GO:0099060 name: integral component of postsynaptic specialization membrane namespace: cellular_component def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane is_a: GO:0099055 ! integral component of postsynaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0099634 ! postsynaptic specialization membrane [Term] id: GO:0099061 name: integral component of postsynaptic density membrane namespace: cellular_component def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0099060 ! integral component of postsynaptic specialization membrane is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098839 ! postsynaptic density membrane [Term] id: GO:0099062 name: integral component of postsynaptic early endosome membrane namespace: cellular_component def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane is_a: GO:0099064 ! integral component of postsynaptic endosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098896 ! postsynaptic early endosome membrane [Term] id: GO:0099063 name: integral component of postsynaptic recycling endosome membrane namespace: cellular_component def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane is_a: GO:0099064 ! integral component of postsynaptic endosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098944 ! postsynaptic recycling endosome membrane [Term] id: GO:0099064 name: integral component of postsynaptic endosome membrane namespace: cellular_component def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0031303 ! integral component of endosome membrane is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098895 ! postsynaptic endosome membrane [Term] id: GO:0099065 name: integral component of spine apparatus membrane namespace: cellular_component def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098952 ! intrinsic component of spine apparatus membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098897 ! spine apparatus membrane [Term] id: GO:0099066 name: integral component of neuronal dense core vesicle membrane namespace: cellular_component def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0099012 ! neuronal dense core vesicle membrane [Term] id: GO:0099067 name: integral component of presynaptic endosome membrane namespace: cellular_component def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0031303 ! integral component of endosome membrane is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0098954 ! presynaptic endosome membrane [Term] id: GO:0099068 name: postsynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL] synonym: "postsynapse biogenesis" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099173 ! postsynapse organization relationship: part_of GO:0007416 ! synapse assembly [Term] id: GO:0099069 name: synaptic vesicle tethering involved in synaptic vesicle exocytosis namespace: biological_process def: "The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion." [GOC:rn] is_a: GO:0090522 ! vesicle tethering involved in exocytosis relationship: part_of GO:0016081 ! synaptic vesicle docking [Term] id: GO:0099070 name: static microtubule bundle namespace: cellular_component def: "A microtubule bundle that has a constant length, and in which microtubule sliding does not take place." [GOC:vw, PMID:26124291] comment: In fission yeast, quiescent cells contain only static microtubule bundles. synonym: "Q-MT bundle" NARROW [] synonym: "quiescent cell microtubule bundle" NARROW [] synonym: "quiescent cell MT bundle" NARROW [] is_a: GO:0097427 ! microtubule bundle [Term] id: GO:0099071 name: dynamic microtubule bundle namespace: cellular_component def: "A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place." [GOC:vw, PMID:26124291] is_a: GO:0097427 ! microtubule bundle [Term] id: GO:0099072 name: regulation of postsynaptic membrane neurotransmitter receptor levels namespace: biological_process def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0099073 name: mitochondrion-derived vesicle namespace: cellular_component def: "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790] synonym: "MDV" EXACT [PMID:26618722] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0099074 name: mitochondrion to lysosome transport namespace: biological_process def: "Transport from the mitochondrion to the lysosome, mediated by mitochondrion-derived vesicles" [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] is_a: GO:0007041 ! lysosomal transport is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport [Term] id: GO:0099075 name: mitochondrion-derived vesicle mediated transport namespace: biological_process def: "Transport from the mitochondrion, mediated by mitochondrion derived vesicles." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:2061965, PMID:20619655] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0099076 name: mitochondrion to peroxisome transport namespace: biological_process def: "Transport from the mitochondrion to the peroxisome, mediated by mitochondrion-derived vesicles." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport [Term] id: GO:0099077 name: histone-dependent DNA binding namespace: molecular_function def: "DNA-binding activity that is dependent on binding to a histone." [PMID:11691835] is_a: GO:0003677 ! DNA binding [Term] id: GO:0099078 name: BORC complex namespace: cellular_component def: "A protein complex that is invovled in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0099079 name: actin body namespace: cellular_component def: "An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin." [PMID:16914523] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0099080 name: supramolecular complex namespace: cellular_component def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0099081 name: supramolecular polymer namespace: cellular_component def: "A polymeric supramolecular structure." [GOC:dos] is_a: GO:0099080 ! supramolecular complex [Term] id: GO:0099082 name: retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide [Term] id: GO:0099083 name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission [Term] id: GO:0099084 name: postsynaptic specialization organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:BHF, GOC:sjp, PMID:21525273, PMID:26834556] subset: goslim_synapse synonym: "post synaptic specialization organization" EXACT [] synonym: "post-synaptic specialization organization" EXACT [] synonym: "postsynaptic specialization organisation" EXACT [] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0099173 ! postsynapse organization created_by: paola creation_date: 2011-07-27T05:17:12Z [Term] id: GO:0099085 name: DIF dechlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-" [PMID:1521542, PMID:22035794] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity" EXACT [] synonym: "1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity" EXACT [] synonym: "DIF-1 3(5)-dechlorinase activity" EXACT [] synonym: "DIF-1 dechlorinase activity" EXACT [] synonym: "differentiation-inducing factor 1 dechlorinase activity" EXACT [] synonym: "differentiation-inducing factor dechlorinase activity" EXACT [] is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0099086 name: synaptonemal structure namespace: cellular_component def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh, GOC:vw] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0099087 name: anterograde axonal transport of messenger ribonucleoprotein complex namespace: biological_process def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse." [GOC:dos, PMID:26586091] subset: goslim_synapse synonym: "anterograde axonal transport of mRNA RNP complex" EXACT [] is_a: GO:0099088 ! axonal transport of messenger ribonucleoprotein complex is_a: GO:0099641 ! anterograde axonal protein transport [Term] id: GO:0099088 name: axonal transport of messenger ribonucleoprotein complex namespace: biological_process def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons." [GOC:dos, PMID:26586091] subset: goslim_synapse synonym: "axonal transport of mRNA RNP complex" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0050658 ! RNA transport is_a: GO:0098930 ! axonal transport is_a: GO:0099640 ! axo-dendritic protein transport relationship: occurs_in GO:1904115 ! axon cytoplasm [Term] id: GO:0099089 name: establishment of endoplasmic reticulum localization to postsynapse namespace: biological_process def: "The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine." [GOC:dos, PMID:21151132] subset: goslim_synapse synonym: "establishment of ER localization to postsynapse" EXACT [GOC:dos] is_a: GO:0051686 ! establishment of ER localization [Term] id: GO:0099091 name: postsynaptic specialization, intracellular component namespace: cellular_component def: "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] subset: goslim_synapse is_a: GO:0043228 ! non-membrane-bounded organelle intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0099572 ! postsynaptic specialization relationship: part_of GO:0099572 ! postsynaptic specialization [Term] id: GO:0099092 name: postsynaptic density, intracellular component namespace: cellular_component def: "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] subset: goslim_synapse is_a: GO:0099091 ! postsynaptic specialization, intracellular component intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0014069 ! postsynaptic density relationship: part_of GO:0014069 ! postsynaptic density [Term] id: GO:0099093 name: calcium export from the mitochondrion namespace: biological_process def: "A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol." [GOC:dos, GOC:vw] synonym: "calcium ion transmembrane export from mitochondrion" EXACT [] synonym: "mitochondrial calcium ion export" BROAD [GOC:vw] synonym: "mitochondrial calcium release" EXACT [] is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:1901660 ! calcium ion export is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0099094 name: ligand-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0099095 name: ligand-gated anion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005253 ! anion channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0099096 name: vestibular calyx terminal namespace: cellular_component def: "The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell." [PMID:10706428, PMID:25355208] is_a: GO:0043679 ! axon terminus [Term] id: GO:0099097 name: prospore membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a prospore membrane." [GOC:dos, GOC:vw, PMID:27630265] is_a: GO:0044091 ! membrane biogenesis [Term] id: GO:0099098 name: microtubule polymerization based movement namespace: biological_process def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194] is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: has_part GO:0046785 ! microtubule polymerization relationship: has_part GO:0046785 ! microtubule polymerization [Term] id: GO:0099099 name: G-protein gated ion channel activity namespace: molecular_function def: "An ion channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022836 ! gated channel activity [Term] id: GO:0099100 name: G-protein gated cation channel activity namespace: molecular_function def: "A cation channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos] is_a: GO:0005261 ! cation channel activity is_a: GO:0099099 ! G-protein gated ion channel activity [Term] id: GO:0099101 name: G-protein gated potassium channel activity namespace: molecular_function def: "A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos, PMID:9429760] is_a: GO:0005267 ! potassium channel activity is_a: GO:0099100 ! G-protein gated cation channel activity [Term] id: GO:0099102 name: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential." [GOC:dos, PMID:9429760] subset: goslim_synapse is_a: GO:0099101 ! G-protein gated potassium channel activity intersection_of: GO:0099101 ! G-protein gated potassium channel activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0099103 name: channel activator activity namespace: molecular_function def: "Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos] synonym: "channel gating activity" EXACT [] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0099104 name: potassium channel activator activity namespace: molecular_function def: "Direct interaction with a potassium channel (binding or modification), resulting in its opening." [GOC:dos] is_a: GO:0015459 ! potassium channel regulator activity is_a: GO:0099103 ! channel activator activity [Term] id: GO:0099105 name: ion channel modulating, G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel." [GOC:dos] synonym: "ion channel modulating, G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: has_part GO:0005216 ! ion channel activity intersection_of: has_part GO:0099106 ! ion channel regulator activity relationship: has_part GO:0005216 ! ion channel activity relationship: has_part GO:0099106 ! ion channel regulator activity [Term] id: GO:0099106 name: ion channel regulator activity namespace: molecular_function def: "Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos] is_a: GO:0016247 ! channel regulator activity relationship: regulates GO:0015267 ! channel activity [Term] id: GO:0099107 name: ion channel regulator activity involved in G protein-coupled receptor signaling pathway namespace: molecular_function def: "Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling." [GOC:dos] synonym: "ion channel regulator activity involved in G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0099106 ! ion channel regulator activity intersection_of: GO:0099106 ! ion channel regulator activity intersection_of: part_of GO:0007186 ! G protein-coupled receptor signaling pathway relationship: part_of GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0099108 name: potassium channel activator activity involved in G protein-coupled receptor signaling pathway namespace: molecular_function def: "Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling." [PMID:9429760] comment: Examples include G-protein beta-gamma complexes that bind to and activate potassium channels. subset: goslim_synapse synonym: "potassium channel activator activity involved in G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0099104 ! potassium channel activator activity is_a: GO:0099107 ! ion channel regulator activity involved in G protein-coupled receptor signaling pathway intersection_of: GO:0099104 ! potassium channel activator activity intersection_of: part_of GO:0007186 ! G protein-coupled receptor signaling pathway relationship: part_of GO:0099109 ! potassium channel activating, G protein-coupled receptor signaling pathway [Term] id: GO:0099109 name: potassium channel activating, G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel." [GOC:dos, PMID:9429760] synonym: "potassium channel activating, G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0099105 ! ion channel modulating, G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: has_part GO:0005267 ! potassium channel activity intersection_of: has_part GO:0099104 ! potassium channel activator activity relationship: has_part GO:0005267 ! potassium channel activity relationship: has_part GO:0099104 ! potassium channel activator activity [Term] id: GO:0099110 name: microtubule polymerization based protein transport to cell tip cortex namespace: biological_process def: "The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached." [GOC:dos, GOC:vw, PMID:11018050] is_a: GO:0099112 ! microtubule polymerization based protein transport is_a: GO:1990896 ! protein localization to cell cortex of cell tip [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0099112 name: microtubule polymerization based protein transport namespace: biological_process def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0099098 ! microtubule polymerization based movement is_a: GO:0099118 ! microtubule-based protein transport [Term] id: GO:0099113 name: negative regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0051481 ! negative regulation of cytosolic calcium ion concentration is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration intersection_of: GO:0051481 ! negative regulation of cytosolic calcium ion concentration intersection_of: occurs_in GO:0098793 ! presynapse [Term] id: GO:0099114 name: chromatin silencing at subtelomere namespace: biological_process def: "Repression of transcription of subtelomeric DNA by altering the structure of chromatin." [PMID:22771823, PMID:26205977] synonym: "heterochromatic silencing at subtelomere" EXACT [] synonym: "subtelomere chromatin silencing" EXACT [GOC:mah] synonym: "subtelomeric silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing intersection_of: GO:0006342 ! chromatin silencing intersection_of: occurs_in GO:0099115 ! chromosome, subtelomeric region relationship: occurs_in GO:0099115 ! chromosome, subtelomeric region [Term] id: GO:0099115 name: chromosome, subtelomeric region namespace: cellular_component def: "A heterochromatic region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes." [GOC:mah, PMID:22771823, PMID:26205977] synonym: "subtelomere" EXACT [] xref: SO:0001997 is_a: GO:0098687 ! chromosomal region [Term] id: GO:0099116 name: tRNA 5'-end processing namespace: biological_process def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:dos, GOC:pf, PMID:27484477] synonym: "tRNA 5' processing" EXACT [] is_a: GO:0008033 ! tRNA processing is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0099117 name: protein transport along microtubule to cell tip namespace: biological_process def: "The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins." [PMID:15177031] is_a: GO:0098840 ! protein transport along microtubule is_a: GO:1990151 ! protein localization to cell tip created_by: vw creation_date: 2015-09-15T11:09:54Z [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport [Term] id: GO:0099119 name: 3-demethylubiquinone-8 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-8 = S-adenosyl-L-homocysteine + ubiquinone-8." [GOC:ic] is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity [Term] id: GO:0099120 name: socially cooperative development namespace: biological_process def: "Development a structure consisting of multiple co-operating unicellular organisms of the same species. Examples include sorocarp development in Dictystelia and co-operative colonial structures formed by Myxococcus xanthus for the purpose of predation and fruiting body formation." [PMID:12448714] synonym: "colonial development" EXACT [] synonym: "socially co-operative development" EXACT [] is_a: GO:0048856 ! anatomical structure development is_a: GO:0051703 ! intraspecies interaction between organisms [Term] id: GO:0099121 name: fungal sorus development namespace: biological_process def: "The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure." [GOC:dos] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0099122 name: RNA polymerase II C-terminal domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." [PMID:20889714] synonym: "RNAP II C-terminal binding" EXACT [] is_a: GO:0000993 ! RNA polymerase II complex binding [Term] id: GO:0099123 name: somato-dendritic dopamine secretion namespace: biological_process def: "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." [GOC:bf, GOC:PARL, PMID:21576241] synonym: "somatodendritic dopamine release" EXACT [PMID:21576241] synonym: "STD DA release" EXACT [PMID:21576241] synonym: "STD dopamine release" EXACT [PMID:21576241] is_a: GO:0014046 ! dopamine secretion intersection_of: GO:0014046 ! dopamine secretion intersection_of: occurs_in GO:0036477 ! somatodendritic compartment relationship: occurs_in GO:0036477 ! somatodendritic compartment [Term] id: GO:0099124 name: axonal dopamine secretion namespace: biological_process def: "The regulated release of dopamine from an axon." [GOC:bf, GOC:PARL, PMID:21576241] synonym: "axonal DA release" EXACT [PMID:21576241] synonym: "axonal dopamine release" EXACT [PMID:21576241] is_a: GO:0014046 ! dopamine secretion intersection_of: GO:0014046 ! dopamine secretion intersection_of: occurs_in GO:0030424 ! axon relationship: occurs_in GO:0030424 ! axon [Term] id: GO:0099125 name: PAK family kinase-Sog2 complex namespace: cellular_component def: "A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network." [PMID:23462181] is_a: GO:1902911 ! protein kinase complex [Term] id: GO:0099126 name: transforming growth factor beta complex namespace: cellular_component def: "A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP." [GOC:bhm, PMID:22943793] synonym: "TGF-beta complex" EXACT [] synonym: "TGF-beta dimer" EXACT [] synonym: "TGFB complex" EXACT [] synonym: "TGFB dimer" EXACT [] synonym: "TGFbeta complex" EXACT [] synonym: "TGFbeta dimer" EXACT [] xref: IntAct:EBI-12501958 xref: IntAct:EBI-12502251 xref: IntAct:EBI-12502440 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0099127 name: envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism." [PMID:19491403] is_a: GO:0035738 ! envenomation resulting in modification of morphology or physiology of other organism relationship: has_part GO:1905753 ! positive regulation of argininosuccinate synthase activity [Term] id: GO:0099128 name: mitochondrial iron-sulfur cluster assembly complex namespace: cellular_component def: "A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine." [PMID:27519411] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0099129 name: cochlear outer hair cell electromotile response namespace: biological_process def: "A rapid, force generating length change of an outer hair cell in response to electical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification." [PMID:12239568, PMID:2187727] is_a: GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0099130 name: estrogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with any estrogen." [GOC:dos] is_a: GO:0042562 ! hormone binding [Term] id: GO:0099134 name: chimeric sorocarp development namespace: biological_process def: "Development of a sorocarp formed by aggregation of cells with different genotypes." [PMID:18272966] subset: gocheck_do_not_manually_annotate is_a: GO:0030587 ! sorocarp development is_a: GO:0099136 ! chimeric non-reproductive fruiting body development [Term] id: GO:0099135 name: chimeric colonial development namespace: biological_process def: "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype." [PMID:18272966] subset: gocheck_do_not_manually_annotate is_a: GO:0099120 ! socially cooperative development [Term] id: GO:0099136 name: chimeric non-reproductive fruiting body development namespace: biological_process def: "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes." [PMID:18272966] subset: gocheck_do_not_manually_annotate is_a: GO:0090702 ! non-reproductive fruiting body development is_a: GO:0099135 ! chimeric colonial development [Term] id: GO:0099137 name: altruistic, chimeric, non-reproductive fruiting body development namespace: biological_process def: "Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966] synonym: "fully co-operative, chimeric, non-reproductive fruiting body development" EXACT [] is_a: GO:0099136 ! chimeric non-reproductive fruiting body development [Term] id: GO:0099138 name: altruistic, chimeric sorocarp development namespace: biological_process def: "Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966] synonym: "fully co-operative, chimeric sorocarp development" EXACT [] is_a: GO:0099134 ! chimeric sorocarp development is_a: GO:0099137 ! altruistic, chimeric, non-reproductive fruiting body development [Term] id: GO:0099139 name: cheating during chimeric sorocarp development namespace: biological_process def: "Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes." [PMID:18272966] is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation relationship: part_of GO:0099134 ! chimeric sorocarp development [Term] id: GO:0099140 name: presynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099187 ! presynaptic cytoskeleton organization created_by: dos creation_date: 2017-06-09T18:34:19Z [Term] id: GO:0099141 name: cellular response to protozoan namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:dos] is_a: GO:0001562 ! response to protozoan [Term] id: GO:0099142 name: intracellularly ATP-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:9755289] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0035381 ! ATP-gated ion channel activity [Term] id: GO:0099143 name: presynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a presynapse" [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: part_of GO:0098793 ! presynapse created_by: dos creation_date: 2017-06-09T18:36:19Z [Term] id: GO:0099144 name: anchored component of synaptic membrane namespace: cellular_component def: "The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0046658 ! anchored component of plasma membrane is_a: GO:0099240 ! intrinsic component of synaptic membrane intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0097060 ! synaptic membrane created_by: dos creation_date: 2017-05-25T17:25:19Z [Term] id: GO:0099145 name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0051223 ! regulation of protein transport is_a: GO:0065008 ! regulation of biological quality is_a: GO:1902683 ! regulation of receptor localization to synapse is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098967 ! exocytic insertion of neurotransmitter receptor to postsynaptic membrane relationship: regulates GO:0098967 ! exocytic insertion of neurotransmitter receptor to postsynaptic membrane created_by: dos creation_date: 2017-06-09T18:49:26Z [Term] id: GO:0099146 name: intrinsic component of postsynaptic density membrane namespace: cellular_component def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to postsynaptic specialization membrane" NARROW [] is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0098839 ! postsynaptic density membrane relationship: part_of GO:0098839 ! postsynaptic density membrane created_by: dos creation_date: 2017-07-05T10:43:24Z [Term] id: GO:0099147 name: extrinsic component of postsynaptic density membrane namespace: cellular_component def: "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] subset: goslim_synapse is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0098839 ! postsynaptic density membrane relationship: part_of GO:0098839 ! postsynaptic density membrane created_by: dos creation_date: 2017-07-05T10:44:43Z [Term] id: GO:0099148 name: regulation of synaptic vesicle docking namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle docking." [GOC:dos] subset: goslim_synapse is_a: GO:0106020 ! regulation of vesicle docking is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016081 ! synaptic vesicle docking relationship: regulates GO:0016081 ! synaptic vesicle docking created_by: dos creation_date: 2017-07-05T13:10:10Z [Term] id: GO:0099149 name: regulation of postsynaptic neurotransmitter receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse." [GOC:ai] subset: goslim_synapse synonym: "regulation of postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0051223 ! regulation of protein transport is_a: GO:0065008 ! regulation of biological quality is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098884 ! postsynaptic neurotransmitter receptor internalization relationship: regulates GO:0098884 ! postsynaptic neurotransmitter receptor internalization created_by: dos creation_date: 2017-07-05T13:13:49Z [Term] id: GO:0099150 name: regulation of postsynaptic specialization assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization." [GOC:dos] subset: goslim_synapse is_a: GO:0150052 ! regulation of postsynapse assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098698 ! postsynaptic specialization assembly relationship: regulates GO:0098698 ! postsynaptic specialization assembly created_by: dos creation_date: 2017-07-05T13:20:48Z [Term] id: GO:0099151 name: regulation of postsynaptic density assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density." [GOC:dos] subset: goslim_synapse is_a: GO:0099150 ! regulation of postsynaptic specialization assembly is_a: GO:1904889 ! regulation of excitatory synapse assembly is_a: GO:1905874 ! regulation of postsynaptic density organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097107 ! postsynaptic density assembly relationship: regulates GO:0097107 ! postsynaptic density assembly created_by: dos creation_date: 2017-07-05T13:20:48Z [Term] id: GO:0099152 name: regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos, PMID:20098723] subset: goslim_synapse is_a: GO:0065008 ! regulation of biological quality is_a: GO:1902683 ! regulation of receptor localization to synapse is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098887 ! neurotransmitter receptor transport, endosome to postsynaptic membrane relationship: regulates GO:0098887 ! neurotransmitter receptor transport, endosome to postsynaptic membrane created_by: dos creation_date: 2017-08-25T15:01:11Z [Term] id: GO:0099153 name: synaptic transmission, serotonergic namespace: biological_process def: "The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] is_a: GO:0007268 ! chemical synaptic transmission created_by: dos creation_date: 2017-07-05T14:16:51Z [Term] id: GO:0099154 name: serotonergic synapse namespace: cellular_component def: "A synapse that uses serotonin as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-07-05T14:22:05Z [Term] id: GO:0099155 name: synaptic transmission, noradrenergic namespace: biological_process def: "The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] is_a: GO:0007268 ! chemical synaptic transmission created_by: dos creation_date: 2017-07-05T14:36:55Z [Term] id: GO:0099156 name: cell-cell signaling via exosome namespace: biological_process def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038] synonym: "exosome mediated" EXACT [] is_a: GO:0007267 ! cell-cell signaling created_by: dos creation_date: 2017-07-05T16:40:45Z [Term] id: GO:0099157 name: trans-synaptic signalling via exosome namespace: biological_process def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] subset: goslim_synapse synonym: "exosome mediated transynaptic signalling" EXACT [] is_a: GO:0099156 ! cell-cell signaling via exosome is_a: GO:0099537 ! trans-synaptic signaling created_by: dos creation_date: 2017-07-05T16:49:44Z [Term] id: GO:0099158 name: regulation of recycling endosome localization within postsynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse." [GOC:dos, PMID:20098723] subset: goslim_synapse is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:1903421 ! regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036466 ! synaptic vesicle recycling via endosome relationship: regulates GO:0036466 ! synaptic vesicle recycling via endosome created_by: dos creation_date: 2017-08-25T15:37:50Z [Term] id: GO:0099159 name: regulation of modification of postsynaptic structure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure." [GOC:dos] subset: goslim_synapse synonym: "regulation of postsynapse remodelling" EXACT [] is_a: GO:1905244 ! regulation of modification of synaptic structure intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099010 ! modification of postsynaptic structure relationship: regulates GO:0099010 ! modification of postsynaptic structure created_by: dos creation_date: 2017-08-25T15:47:55Z [Term] id: GO:0099160 name: postsynaptic intermediate filament cytoskeleton namespace: cellular_component def: "The intermediate filament cytoskeleton that is part of a postsynapse" [GOC:dos, PMID:25869803] subset: goslim_synapse is_a: GO:0045111 ! intermediate filament cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0045111 ! intermediate filament cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse created_by: dos creation_date: 2017-08-28T15:26:08Z [Term] id: GO:0099161 name: regulation of presynaptic dense core granule exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis." [GOC:dos, PMID:17881523] subset: goslim_synapse synonym: "regulation of presynaptic dense core vesicle exocytosis" EXACT syngo_official_label [] is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099525 ! presynaptic dense core vesicle exocytosis relationship: regulates GO:0099525 ! presynaptic dense core vesicle exocytosis created_by: dos creation_date: 2017-09-10T10:59:08Z [Term] id: GO:0099162 name: regulation of neurotransmitter loading into synaptic vesicle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles." [GOC:dos, PMID:25176177] subset: goslim_synapse synonym: "regulation of neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342] synonym: "regulation of synaptic vesicle neurotransmitter loading" EXACT syngo_official_label [] is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0098693 ! regulation of synaptic vesicle cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098700 ! neurotransmitter loading into synaptic vesicle relationship: regulates GO:0098700 ! neurotransmitter loading into synaptic vesicle created_by: dos creation_date: 2017-09-10T11:07:57Z [Term] id: GO:0099163 name: synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by nitric oxide." [GOC:dos, PMID:19038221] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099164 name: postsynaptic specialization membrane of symmetric synapse namespace: cellular_component def: "The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] subset: goslim_synapse is_a: GO:0099634 ! postsynaptic specialization membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane intersection_of: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse created_by: dos creation_date: 2017-09-10T11:50:44Z [Term] id: GO:0099165 name: postsynaptic specialization of symmetric synapse, intracellular component namespace: cellular_component def: "A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses." [GOC:dos] subset: goslim_synapse is_a: GO:0099091 ! postsynaptic specialization, intracellular component intersection_of: GO:0043228 ! non-membrane-bounded organelle intersection_of: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse created_by: dos creation_date: 2017-09-10T11:54:15Z [Term] id: GO:0099166 name: intrinsic component of postsynaptic specialization membrane of symmetric synapse namespace: cellular_component def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] subset: goslim_synapse synonym: "intrinsic to postsynaptic specialization membrane of symmetric synapse" NARROW [] is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse created_by: dos creation_date: 2017-09-10T11:56:47Z [Term] id: GO:0099167 name: integral component of postsynaptic specialization membrane of symmetric synapse namespace: cellular_component def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0099060 ! integral component of postsynaptic specialization membrane is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse created_by: dos creation_date: 2017-09-10T11:58:46Z [Term] id: GO:0099168 name: extrinsic component of postsynaptic specialization membrane of symmetric synapse namespace: cellular_component def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] subset: goslim_synapse is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse created_by: dos creation_date: 2017-09-10T12:00:26Z [Term] id: GO:0099169 name: anchored component of postsynaptic specialization membrane of symmetric synapse namespace: cellular_component def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] subset: goslim_synapse is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse intersection_of: GO:0031225 ! anchored component of membrane intersection_of: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse created_by: dos creation_date: 2017-09-10T12:01:53Z [Term] id: GO:0099170 name: postsynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse created_by: dos creation_date: 2017-09-11T17:09:17Z [Term] id: GO:0099171 name: presynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: occurs_in GO:0098793 ! presynapse relationship: occurs_in GO:0098793 ! presynapse created_by: dos creation_date: 2017-09-11T17:09:31Z [Term] id: GO:0099172 name: presynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynapse development" EXACT [] synonym: "presynapse morphogenesis" RELATED [GOC:BHF] synonym: "presynapse organisation" EXACT [] synonym: "presynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0099173 name: postsynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynapse development" EXACT [] synonym: "postsynapse morphogenesis" RELATED [GOC:BHF] synonym: "postsynapse organisation" EXACT [] synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0099174 name: regulation of presynapse organization namespace: biological_process def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of presynapse organisation" EXACT [GOC:mah] synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of presynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099172 ! presynapse organization relationship: regulates GO:0099172 ! presynapse organization [Term] id: GO:0099175 name: regulation of postsynapse organization namespace: biological_process def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of postsynapse organisation" EXACT [GOC:mah] synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of postsynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099173 ! postsynapse organization relationship: regulates GO:0099173 ! postsynapse organization [Term] id: GO:0099176 name: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex." [GOC:dos, PMID:23209303] subset: goslim_synapse synonym: "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098942 ! retrograde trans-synaptic signaling by trans-synaptic protein complex relationship: regulates GO:0098942 ! retrograde trans-synaptic signaling by trans-synaptic protein complex [Term] id: GO:0099177 name: regulation of trans-synaptic signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099537 ! trans-synaptic signaling relationship: regulates GO:0099537 ! trans-synaptic signaling [Term] id: GO:0099178 name: regulation of retrograde trans-synaptic signaling by endocanabinoid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid." [GOC:dos, PMID:15664177] synonym: "regulation of endocannabinoid-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid relationship: regulates GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid [Term] id: GO:0099179 name: regulation of synaptic membrane adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes." [GOC:dos] subset: goslim_synapse synonym: "regulation of synapse adhesion between pre- and post-synapse" EXACT [] {synonymtypedef="syngo_official_label"} is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099560 ! synaptic membrane adhesion relationship: regulates GO:0099560 ! synaptic membrane adhesion [Term] id: GO:0099180 name: zinc ion import into synaptic vesicle namespace: biological_process def: "The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle." [PMID:9990090] subset: goslim_synapse synonym: "zinc import into synaptic vesicle" EXACT [] synonym: "Zn2+ import into synaptic vesicle" EXACT [] is_a: GO:0062111 ! zinc ion import into organelle [Term] id: GO:0099181 name: structural constituent of presynapse namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a presynapse." [GOC:dos, PMID:23751498] subset: goslim_synapse is_a: GO:0098918 ! structural constituent of synapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: part_of GO:0099172 ! presynapse organization relationship: occurs_in GO:0098793 ! presynapse relationship: part_of GO:0099172 ! presynapse organization created_by: dos creation_date: 2017-12-20T13:42:46Z [Term] id: GO:0099182 name: presynaptic intermediate filament cytoskeleton namespace: cellular_component def: "The intermediate filament cytoskeleton that is part of a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0045111 ! intermediate filament cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0045111 ! intermediate filament cytoskeleton intersection_of: part_of GO:0098793 ! presynapse created_by: dos creation_date: 2017-12-01T18:10:21Z [Term] id: GO:0099183 name: trans-synaptic signaling by BDNF, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099191 ! trans-synaptic signaling by BDNF is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission created_by: dos creation_date: 2017-12-01T18:25:24Z [Term] id: GO:0099184 name: structural constituent of postsynaptic intermediate filament cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0005200 ! structural constituent of cytoskeleton is_a: GO:0099186 ! structural constituent of postsynapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0099160 ! postsynaptic intermediate filament cytoskeleton intersection_of: part_of GO:0099185 ! postsynaptic intermediate filament cytoskeleton organization relationship: occurs_in GO:0099160 ! postsynaptic intermediate filament cytoskeleton relationship: part_of GO:0099185 ! postsynaptic intermediate filament cytoskeleton organization created_by: dos creation_date: 2017-12-20T13:45:35Z [Term] id: GO:0099185 name: postsynaptic intermediate filament cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0045104 ! intermediate filament cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization created_by: dos creation_date: 2017-12-20T13:47:30Z [Term] id: GO:0099186 name: structural constituent of postsynapse namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0098918 ! structural constituent of synapse intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: part_of GO:0099173 ! postsynapse organization relationship: occurs_in GO:0098794 ! postsynapse relationship: part_of GO:0099173 ! postsynapse organization created_by: dos creation_date: 2017-12-20T14:54:33Z [Term] id: GO:0099187 name: presynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos] is_a: GO:0007010 ! cytoskeleton organization relationship: part_of GO:0099172 ! presynapse organization created_by: dos creation_date: 2017-12-20T15:05:34Z [Term] id: GO:0099188 name: postsynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0007010 ! cytoskeleton organization relationship: part_of GO:0099173 ! postsynapse organization created_by: dos creation_date: 2017-12-20T15:06:57Z [Term] id: GO:0099189 name: postsynaptic spectrin-associated cytoskeleton namespace: cellular_component def: "The portion of the spectrin-associated cytoskeleton contained within the postsynapse." [GOC:dos, PMID:28576936] subset: goslim_synapse is_a: GO:0014731 ! spectrin-associated cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0014731 ! spectrin-associated cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse created_by: dos creation_date: 2017-12-20T15:29:09Z [Term] id: GO:0099190 name: postsynaptic spectrin-associated cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse." [GOC:dos, PMID:28576936] subset: goslim_synapse is_a: GO:0099188 ! postsynaptic cytoskeleton organization created_by: dos creation_date: 2017-12-20T15:34:26Z [Term] id: GO:0099191 name: trans-synaptic signaling by BDNF namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse synonym: "trans-synaptic signaling by brain-derived neurotrophic factor" EXACT [] is_a: GO:0099537 ! trans-synaptic signaling created_by: dos creation_date: 2017-12-20T15:48:33Z [Term] id: GO:0099192 name: cerebellar Golgi cell to granule cell synapse namespace: cellular_component def: "A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell." [PMID:26134650] subset: goslim_synapse is_a: GO:0045202 ! synapse created_by: dos creation_date: 2017-12-20T16:12:25Z [Term] id: GO:0099240 name: intrinsic component of synaptic membrane namespace: cellular_component def: "The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] subset: goslim_synapse synonym: "intrinsic to synaptic membrane" NARROW [] is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0097060 ! synaptic membrane relationship: part_of GO:0097060 ! synaptic membrane created_by: dos creation_date: 2017-05-25T17:23:21Z [Term] id: GO:0099243 name: extrinsic component of synaptic membrane namespace: cellular_component def: "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] subset: goslim_synapse is_a: GO:0019897 ! extrinsic component of plasma membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0097060 ! synaptic membrane relationship: part_of GO:0097060 ! synaptic membrane created_by: dos creation_date: 2017-05-25T17:24:23Z [Term] id: GO:0099400 name: caveola neck namespace: cellular_component def: "A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it." [GOC:pad, GOC:PARL, PMID:17227843] is_a: GO:0098590 ! plasma membrane region is_a: GO:0098857 ! membrane microdomain relationship: part_of GO:0005901 ! caveola [Term] id: GO:0099401 name: caveola bulb namespace: cellular_component def: "The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins." [GOC:PARL, GOC:POD, PMID:17227843] synonym: "caveola crater" EXACT [] is_a: GO:0098857 ! membrane microdomain [Term] id: GO:0099402 name: plant organ development namespace: biological_process def: "Development of a plant organ, a multi-tissue plant structure that forms a functional unit." [GOC:dos] synonym: "development of a plant organ" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development [Term] id: GO:0099403 name: maintenance of mitotic sister chromatid cohesion, telomeric namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:rph, PMID:26373281] synonym: "maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:mah] synonym: "maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:mah] synonym: "maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah] is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion relationship: part_of GO:0099404 ! mitotic sister chromatid cohesion, telomeric [Term] id: GO:0099404 name: mitotic sister chromatid cohesion, telomeric namespace: biological_process def: "The cell cycle process in which telomeres of sister chromatids are joined during mitosis." [GOC:BHF, GOC:BHF_telomere, GOC:mah, GOC:rph, PMID:26373281] synonym: "mitotic sister chromatid cohesion at telomere" EXACT [GOC:mah] synonym: "sister chromatid cohesion at telomere at mitosis" EXACT [GOC:mah] synonym: "telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah] is_a: GO:0007064 ! mitotic sister chromatid cohesion [Term] id: GO:0099500 name: vesicle fusion to plasma membrane namespace: biological_process def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] is_a: GO:0006906 ! vesicle fusion is_a: GO:0140029 ! exocytic process [Term] id: GO:0099501 name: exocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an exocytic vesicle" [GOC:dos] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030658 ! transport vesicle membrane [Term] id: GO:0099502 name: calcium-dependent activation of synaptic vesicle fusion namespace: biological_process def: "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane." [PMID:23060190] subset: goslim_synapse is_a: GO:0031632 ! positive regulation of synaptic vesicle fusion to presynaptic active zone membrane is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0099504 name: synaptic vesicle cycle namespace: biological_process def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342] subset: goslim_synapse is_a: GO:0099003 ! vesicle-mediated transport in synapse relationship: occurs_in GO:0098793 ! presynapse [Term] id: GO:0099505 name: regulation of presynaptic membrane potential namespace: biological_process def: "Any process that modulates the potential difference across a presynaptic membrane." [GOC:dph, GOC:ef] subset: goslim_synapse synonym: "regulation of pre-synaptic membrane potential" EXACT [] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0099506 name: synaptic vesicle transport along actin filament namespace: biological_process def: "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors." [GOC:dos] subset: goslim_synapse is_a: GO:0030050 ! vesicle transport along actin filament is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport [Term] id: GO:0099507 name: ligand-gated ion channel activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:15145529, PMID:19558451] subset: goslim_synapse synonym: "ligand gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] synonym: "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] synonym: "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] synonym: "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] is_a: GO:0015276 ! ligand-gated ion channel activity intersection_of: GO:0015276 ! ligand-gated ion channel activity intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential relationship: occurs_in GO:0042734 ! presynaptic membrane relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential [Term] id: GO:0099508 name: voltage-gated ion channel activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse." [GOC:dos] subset: goslim_synapse synonym: "voltage gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] synonym: "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] synonym: "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] synonym: "voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] is_a: GO:0005244 ! voltage-gated ion channel activity intersection_of: GO:0005244 ! voltage-gated ion channel activity intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential relationship: occurs_in GO:0042734 ! presynaptic membrane relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential [Term] id: GO:0099509 name: regulation of presynaptic cytosolic calcium ion concentration namespace: biological_process def: "Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos] subset: goslim_synapse synonym: "regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration is_a: GO:0070050 ! neuron cellular homeostasis intersection_of: GO:0051480 ! regulation of cytosolic calcium ion concentration intersection_of: occurs_in GO:0098793 ! presynapse relationship: occurs_in GO:0098793 ! presynapse [Term] id: GO:0099510 name: calcium ion binding involved in regulation of cytosolic calcium ion concentration namespace: molecular_function def: "The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] synonym: "regulation of cytosolic calcium ion concentration by calcium ion buffering" EXACT [] is_a: GO:0005509 ! calcium ion binding intersection_of: GO:0005509 ! calcium ion binding intersection_of: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration relationship: occurs_in GO:0005829 ! cytosol relationship: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0099511 name: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels namespace: molecular_function def: "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel." [GOC:dos] subset: goslim_synapse is_a: GO:0005245 ! voltage-gated calcium channel activity intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration relationship: part_of GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0099512 name: supramolecular fiber namespace: cellular_component alt_id: GO:0043205 def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] synonym: "fibril" RELATED [] is_a: GO:0099081 ! supramolecular polymer [Term] id: GO:0099513 name: polymeric cytoskeletal fiber namespace: cellular_component def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] is_a: GO:0099512 ! supramolecular fiber relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0099514 name: synaptic vesicle cytoskeletal transport namespace: biological_process def: "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors." [GOC:dos] subset: goslim_synapse is_a: GO:0048489 ! synaptic vesicle transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking [Term] id: GO:0099515 name: actin filament-based transport namespace: biological_process def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport created_by: tanyaberardini creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0099517 name: synaptic vesicle transport along microtubule namespace: biological_process def: "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors." [GOC:dos] subset: goslim_synapse is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport [Term] id: GO:0099518 name: vesicle cytoskeletal trafficking namespace: biological_process def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl] synonym: "vesicle cytoskeletal transport" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0051650 ! establishment of vesicle localization [Term] id: GO:0099519 name: dense core granule cytoskeletal transport namespace: biological_process def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451] synonym: "dense core granule cytoskeletal transport" EXACT [] synonym: "dense core vesicle cytoskeletal trafficking" EXACT [] is_a: GO:0099518 ! vesicle cytoskeletal trafficking is_a: GO:1901950 ! dense core granule transport relationship: occurs_in GO:0030424 ! axon [Term] id: GO:0099520 name: ion antiporter activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential" [GOC:dos] subset: goslim_synapse synonym: "ion antiporter activity involved in regulation of pre-synaptic membrane potential" EXACT [] is_a: GO:0015297 ! antiporter activity relationship: occurs_in GO:0042734 ! presynaptic membrane [Term] id: GO:0099521 name: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:17220883] subset: goslim_synapse synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential" EXACT [] synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" EXACT [] is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity intersection_of: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential relationship: occurs_in GO:0042734 ! presynaptic membrane relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential [Term] id: GO:0099522 name: region of cytosol namespace: cellular_component def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol" [GOC:dos] is_a: GO:0005829 ! cytosol intersection_of: GO:0005829 ! cytosol intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0099523 name: presynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! region of cytosol intersection_of: GO:0005829 ! cytosol intersection_of: part_of GO:0005829 ! cytosol intersection_of: part_of GO:0098793 ! presynapse relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0099524 name: postsynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! region of cytosol intersection_of: GO:0005829 ! cytosol intersection_of: part_of GO:0005829 ! cytosol intersection_of: part_of GO:0098794 ! postsynapse relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099525 name: presynaptic dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208] subset: goslim_synapse is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter is_a: GO:0099011 ! neuronal dense core vesicle exocytosis [Term] id: GO:0099526 name: presynapse to nucleus signaling pathway namespace: biological_process def: "A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077] comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term. subset: goslim_synapse synonym: "presynaptic signaling to nucleus" EXACT [] is_a: GO:0098928 ! presynaptic signal transduction [Term] id: GO:0099527 name: postsynapse to nucleus signaling pathway namespace: biological_process def: "A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077] subset: goslim_synapse synonym: "postsynaptic signaling to nucleus" EXACT [] is_a: GO:0098926 ! postsynaptic signal transduction [Term] id: GO:0099528 name: G protein-coupled neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "G-protein coupled neurotransmitter receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0099529 name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.)" [GOC:dos] subset: goslim_synapse is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0099530 name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos] subset: goslim_synapse synonym: "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential relationship: occurs_in GO:0045211 ! postsynaptic membrane relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0099531 name: presynaptic process involved in chemical synaptic transmission namespace: biological_process def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] subset: gocheck_do_not_annotate subset: goslim_synapse is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: part_of GO:0007268 ! chemical synaptic transmission relationship: occurs_in GO:0098793 ! presynapse relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099532 name: synaptic vesicle endosomal processing namespace: biological_process def: "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:aruk, GOC:bc, GOC:dos] comment: This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. subset: goslim_synapse synonym: "synaptic vesicle processing via endosome" EXACT [] is_a: GO:0016197 ! endosomal transport [Term] id: GO:0099533 name: positive regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: occurs_in GO:0098793 ! presynapse [Term] id: GO:0099534 name: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration namespace: molecular_function def: "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] subset: goslim_synapse synonym: "calcium ion binding involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "presynaptic calcium ion buffering" EXACT [] synonym: "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" EXACT [] is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration intersection_of: GO:0005509 ! calcium ion binding intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: occurs_in GO:0099523 ! presynaptic cytosol relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration [Term] id: GO:0099535 name: synapse-associated extracellular matrix namespace: cellular_component def: "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:dos] subset: goslim_synapse synonym: "extra-synaptic extracellular matrix" EXACT [] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0099536 name: synaptic signaling namespace: biological_process def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse [Term] id: GO:0099537 name: trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099538 name: synaptic signaling via neuropeptide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099539 name: neuropeptide secretion from presynapse namespace: biological_process def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208] subset: goslim_synapse synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT [] is_a: GO:0002790 ! peptide secretion is_a: GO:0099525 ! presynaptic dense core vesicle exocytosis relationship: part_of GO:0099538 ! synaptic signaling via neuropeptide [Term] id: GO:0099540 name: trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling is_a: GO:0099538 ! synaptic signaling via neuropeptide [Term] id: GO:0099541 name: trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0099542 name: trans-synaptic signaling by endocannabinoid namespace: biological_process def: "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0099541 ! trans-synaptic signaling by lipid [Term] id: GO:0099543 name: trans-synaptic signaling by soluble gas namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0099544 name: perisynaptic space namespace: cellular_component def: "The extracellular region immediately adjacent to to a synapse." [GOC:dos] subset: goslim_synapse synonym: "extrasynaptic space" EXACT syngo_official_label [] is_a: GO:0005576 ! extracellular region [Term] id: GO:0099545 name: trans-synaptic signaling by trans-synaptic complex namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling [Term] id: GO:0099546 name: protein catabolic process, modulating synaptic transmission namespace: biological_process def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140246 ! protein catabolic process at synapse [Term] id: GO:0099547 name: regulation of translation at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0045202 ! synapse intersection_of: regulates GO:0006412 ! translation intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099548 name: trans-synaptic signaling by nitric oxide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos] subset: goslim_synapse is_a: GO:0099163 ! synaptic signaling by nitric oxide is_a: GO:0099543 ! trans-synaptic signaling by soluble gas [Term] id: GO:0099549 name: trans-synaptic signaling by carbon monoxide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide." [GOC:dos] subset: goslim_synapse is_a: GO:0099543 ! trans-synaptic signaling by soluble gas [Term] id: GO:0099550 name: trans-synaptic signaling, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099551 name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission [Term] id: GO:0099552 name: trans-synaptic signaling by lipid, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099541 ! trans-synaptic signaling by lipid is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission [Term] id: GO:0099553 name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid is_a: GO:0099552 ! trans-synaptic signaling by lipid, modulating synaptic transmission [Term] id: GO:0099554 name: trans-synaptic signaling by soluble gas, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099543 ! trans-synaptic signaling by soluble gas is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission [Term] id: GO:0099555 name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission [Term] id: GO:0099556 name: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099549 ! trans-synaptic signaling by carbon monoxide is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission [Term] id: GO:0099557 name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:19029886] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission [Term] id: GO:0099558 name: maintenance of synapse structure namespace: biological_process def: "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds." [GOC:dos, PMID:24449494, PMID:25611509] subset: goslim_synapse synonym: "synaptic maintenance" EXACT [] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0050808 ! synapse organization [Term] id: GO:0099559 name: maintenance of alignment of postsynaptic density and presynaptic active zone namespace: biological_process def: "The process by which alignment between postsynaptic density and presynaptic active zone is maintained." [GOC:dos] subset: goslim_synapse is_a: GO:0099558 ! maintenance of synapse structure [Term] id: GO:0099560 name: synaptic membrane adhesion namespace: biological_process def: "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos] subset: goslim_synapse synonym: "synapse adhesion between pre- and post-synapse" EXACT syngo_official_label [] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0099561 name: synaptic membrane adhesion to extracellular matrix namespace: biological_process def: "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules." [GOC:dos] subset: goslim_synapse is_a: GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0050808 ! synapse organization [Term] id: GO:0099562 name: maintenance of postsynaptic density structure namespace: biological_process def: "A process which maintains the organization and the arrangement of proteins in the presynaptic density." [GOC:dos] subset: goslim_synapse is_a: GO:0098880 ! maintenance of postsynaptic specialization structure [Term] id: GO:0099563 name: modification of synaptic structure namespace: biological_process def: "Any process that modifies the structure/morphology of a synapse." [GOC:dos] comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. subset: goslim_synapse synonym: "synapse remodelling" EXACT [] is_a: GO:0050808 ! synapse organization [Term] id: GO:0099564 name: modification of synaptic structure, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission via modification of the structure of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099563 ! modification of synaptic structure [Term] id: GO:0099565 name: chemical synaptic transmission, postsynaptic namespace: biological_process def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos] subset: gocheck_do_not_annotate subset: goslim_synapse synonym: "postsynaptic process involved in chemical synaptic transmission" RELATED syngo_official_label [] is_a: GO:0050877 ! nervous system process is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: part_of GO:0007268 ! chemical synaptic transmission relationship: occurs_in GO:0098794 ! postsynapse relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099566 name: regulation of postsynaptic cytosolic calcium ion concentration namespace: biological_process def: "Any process that regulates the concentration of calcium in the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse synonym: "regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration intersection_of: GO:0051480 ! regulation of cytosolic calcium ion concentration intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse [Term] id: GO:0099567 name: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] subset: goslim_synapse synonym: "calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "postsynaptic calcium ion buffering" EXACT [] synonym: "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED [] is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration intersection_of: GO:0005509 ! calcium ion binding intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: occurs_in GO:0099524 ! postsynaptic cytosol relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\"" [GOC:dos] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0099569 name: presynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0098793 ! presynapse relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0099571 name: postsynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: part_of GO:0098794 ! postsynapse relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099572 name: postsynaptic specialization namespace: cellular_component def: "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] subset: goslim_synapse is_a: GO:0043226 ! organelle relationship: part_of GO:0098794 ! postsynapse [Term] id: GO:0099573 name: glutamatergic postsynaptic density namespace: cellular_component def: "The post-synaptic specialization of a glutamatergic excitatory synapse." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic specialization, glutamatergic neuron-to-neuron synapse" EXACT syngo_official_label [] is_a: GO:0014069 ! postsynaptic density [Term] id: GO:0099574 name: regulation of protein catabolic process at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140250 ! regulation protein catabolic process at synapse [Term] id: GO:0099575 name: regulation of protein catabolic process at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099576 name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099577 name: regulation of translation at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140244 ! regulation of translation at presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: regulates GO:0006412 ! translation intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099578 name: regulation of translation at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140245 ! regulation of translation at postsynapse intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: regulates GO:0006412 ! translation intersection_of: regulates GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099579 name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential." [GOC:dos] subset: goslim_synapse synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential intersection_of: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0099580 name: ion antiporter activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential" [GOC:dos] subset: goslim_synapse synonym: "ion antiporter activity involved in regulation of post-synaptic membrane potential" EXACT [] is_a: GO:0015297 ! antiporter activity relationship: occurs_in GO:0045211 ! postsynaptic membrane [Term] id: GO:0099581 name: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos] subset: goslim_synapse synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential" EXACT [] synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity intersection_of: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential relationship: occurs_in GO:0045211 ! postsynaptic membrane relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential [Term] id: GO:0099582 name: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos] subset: goslim_synapse synonym: "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0030594 ! neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: occurs_in GO:0042734 ! presynaptic membrane relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration [Term] id: GO:0099583 name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse synonym: "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration [Term] id: GO:0099585 name: release of sequestered calcium ion into presynaptic cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration [Term] id: GO:0099586 name: release of sequestered calcium ion into postsynaptic cytosol namespace: biological_process def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0051209 ! release of sequestered calcium ion into cytosol is_a: GO:0099588 ! positive regulation of postsynaptic cytosolic calcium concentration [Term] id: GO:0099587 name: inorganic ion import across plasma membrane namespace: biological_process def: "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "inorganic ion import into cell" EXACT [] is_a: GO:0098660 ! inorganic ion transmembrane transport is_a: GO:0098739 ! import across plasma membrane [Term] id: GO:0099588 name: positive regulation of postsynaptic cytosolic calcium concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration intersection_of: GO:0007204 ! positive regulation of cytosolic calcium ion concentration intersection_of: occurs_in GO:0098794 ! postsynapse [Term] id: GO:0099589 name: serotonin receptor activity namespace: molecular_function def: "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:dos] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0099590 name: neurotransmitter receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos] is_a: GO:0031623 ! receptor internalization is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0099637 ! neurotransmitter receptor transport [Term] id: GO:0099592 name: endocytosed synaptic vesicle processing via endosome namespace: biological_process def: "The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos] synonym: "synaptic vesicle processing via endosome involved in synaptic vesicle recycling" EXACT [] is_a: GO:0099003 ! vesicle-mediated transport in synapse is_a: GO:0099532 ! synaptic vesicle endosomal processing intersection_of: GO:0099532 ! synaptic vesicle endosomal processing intersection_of: part_of GO:0036466 ! synaptic vesicle recycling via endosome relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome [Term] id: GO:0099593 name: endocytosed synaptic vesicle to endosome fusion namespace: biological_process def: "Fusion of an endocytosed synaptic vesicle with an endosome." [GOC:dos] is_a: GO:0016189 ! synaptic vesicle to endosome fusion intersection_of: GO:0016189 ! synaptic vesicle to endosome fusion intersection_of: part_of GO:0036466 ! synaptic vesicle recycling via endosome relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome [Term] id: GO:0099601 name: regulation of neurotransmitter receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] subset: goslim_synapse is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030594 ! neurotransmitter receptor activity relationship: regulates GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0099602 name: neurotransmitter receptor regulator activity namespace: molecular_function def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:25172949] is_a: GO:0030545 ! receptor regulator activity relationship: part_of GO:0099601 ! regulation of neurotransmitter receptor activity [Term] id: GO:0099604 name: ligand-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos] is_a: GO:0005262 ! calcium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity relationship: part_of GO:0019722 ! calcium-mediated signaling [Term] id: GO:0099605 name: regulation of action potential firing rate namespace: biological_process def: "Any process that regulates the frequency of action potentials in a spike train." [ISBN:978-0071390118] is_a: GO:0098900 ! regulation of action potential [Term] id: GO:0099606 name: microtubule plus-end directed mitotic chromosome migration namespace: biological_process def: "The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression." [GOC:dos, PMID:26258632, PMID:26705896] synonym: "plus-end directed chromosome gliding" EXACT [PMID:26258632] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0051303 ! establishment of chromosome localization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007080 ! mitotic metaphase plate congression [Term] id: GO:0099607 name: lateral attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate)." [PMID:26258632, PMID:26705896] is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore [Term] id: GO:0099608 name: regulation of action potential firing pattern namespace: biological_process def: "Any process that regulates the temporal pattern of a sequence of action potentials in a neuron." [ISBN:978-0071390118] synonym: "spike train sculpting" EXACT [] is_a: GO:0098900 ! regulation of action potential relationship: regulates GO:0098874 ! spike train [Term] id: GO:0099609 name: microtubule lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with the side of a microtubule." [GOC:dos] is_a: GO:0008017 ! microtubule binding [Term] id: GO:0099610 name: action potential initiation namespace: biological_process def: "The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate." [ISBN:978-0071390118, PMID:19439602] synonym: "action potential firing" EXACT [] synonym: "action potential triggering" EXACT [] is_a: GO:0001508 ! action potential [Term] id: GO:0099611 name: regulation of action potential firing threshold namespace: biological_process def: "Any process that regulates the potential at which an axon potential is triggered." [ISBN:978-0071390118] is_a: GO:0098900 ! regulation of action potential [Term] id: GO:0099612 name: protein localization to axon namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139] is_a: GO:0008104 ! protein localization [Term] id: GO:0099613 name: protein localization to cell wall namespace: biological_process def: "The process of directing proteins towards the cell-wall." [ISBN:0716731363] is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0099614 name: protein localization to spore cell wall namespace: biological_process def: "A process in which a protein is transported, tethered to or otherwise maintained in a spore cell wall." [GOC:dos] synonym: "protein targeting to spore cell wall" RELATED [] is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0099615 name: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor." [PMID:26774271] synonym: "D-2HG-pyruvate transhydrogenase activity" EXACT [] synonym: "R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity" EXACT [] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0099616 name: extrinsic component of matrix side of mitochondrial inner membrane namespace: cellular_component def: "The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.\"\n" [GOC:dos] is_a: GO:0031314 ! extrinsic component of mitochondrial inner membrane intersection_of: GO:0019898 ! extrinsic component of membrane intersection_of: part_of GO:0099617 ! matrix side of mitochondrial inner membrane relationship: part_of GO:0099617 ! matrix side of mitochondrial inner membrane [Term] id: GO:0099617 name: matrix side of mitochondrial inner membrane namespace: cellular_component def: "The side (leaflet) of the mitochondrial inner membrane that faces the matrix." [GOC:dos] is_a: GO:0098576 ! lumenal side of membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0099618 name: UDP-glucuronic acid dehydrogenase activity namespace: molecular_function def: "Catalytis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+" [GOC:al, GOC:dos] synonym: "UDP-GlcUA decarboxylase activity" EXACT [] xref: EC:1.1.1.305 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0099619 name: UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose" [PMID:15695810, PMID:15807526, PMID:15809294, PMID:15939024, PMID:17928292] synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity" EXACT [] synonym: "ArnAFT activity" EXACT [] synonym: "UDP-L-Ara4N formyltransferase activity" EXACT [] xref: EC:2.1.2.13 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0099620 name: UDP-4-amino-4-deoxy-L-arabinose aminotransferase namespace: molecular_function def: "Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate" [GOC:al, GOC:dos, PMID:12429098, PMID:12704196] synonym: "UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase" EXACT [] synonym: "UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase" EXACT [] synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT [] synonym: "UDP-Ara4O aminotransferase" EXACT [] synonym: "UDP-L-Ara4N transaminase" EXACT [] xref: EC:2.6.1.87 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0099621 name: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity namespace: molecular_function alt_id: GO:0103019 def: "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate." [GOC:al, GOC:dos, PMID:11706007, PMID:15695810] synonym: "Ara4FN transferase activity" EXACT [] synonym: "undecaprenyl phosphate-L-Ara4FN transferase activity" EXACT [] synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT [] xref: EC:2.4.2.53 xref: MetaCyc:RXN0-3521 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0099622 name: cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] is_a: GO:0086009 ! membrane repolarization [Term] id: GO:0099623 name: regulation of cardiac muscle cell membrane repolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte." [GOC:BHF, GOC:dos, GOC:rl] synonym: "heart repolarization" RELATED [] synonym: "regulation of cardiac muscle cell repolarization" EXACT [] synonym: "regulation of cardiomyocyte membrane repolarization" EXACT [] is_a: GO:0060306 ! regulation of membrane repolarization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099622 ! cardiac muscle cell membrane repolarization relationship: regulates GO:0099622 ! cardiac muscle cell membrane repolarization [Term] id: GO:0099624 name: atrial cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] is_a: GO:0099622 ! cardiac muscle cell membrane repolarization [Term] id: GO:0099625 name: ventricular cardiac muscle cell membrane repolarization namespace: biological_process def: "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0099622 ! cardiac muscle cell membrane repolarization [Term] id: GO:0099626 name: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels namespace: molecular_function def: "Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels." [GOC:dos, PMID:15548655] subset: goslim_synapse synonym: "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: occurs_in GO:0098793 ! presynapse relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration [Term] id: GO:0099627 name: neurotransmitter receptor cycle namespace: biological_process def: "The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping)." [GOC:dos] is_a: GO:0099637 ! neurotransmitter receptor transport [Term] id: GO:0099628 name: neurotransmitter receptor diffusion trapping namespace: biological_process def: "The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane." [PMID:18832033] subset: goslim_synapse is_a: GO:0098953 ! receptor diffusion trapping relationship: occurs_in GO:0098590 ! plasma membrane region [Term] id: GO:0099629 name: postsynaptic specialization of symmetric synapse namespace: cellular_component def: "A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses." [PMID:18832033] subset: goslim_synapse synonym: "postsynaptic density of inhibitory synapse" EXACT [PMID:18832033] is_a: GO:0099572 ! postsynaptic specialization intersection_of: GO:0099572 ! postsynaptic specialization intersection_of: part_of GO:0032280 ! symmetric synapse relationship: part_of GO:0032280 ! symmetric synapse [Term] id: GO:0099630 name: postsynaptic neurotransmitter receptor cycle namespace: biological_process def: "The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane." [PMID:18832033] is_a: GO:0099627 ! neurotransmitter receptor cycle intersection_of: GO:0099627 ! neurotransmitter receptor cycle intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse [Term] id: GO:0099631 name: postsynaptic endocytic zone cytoplasmic component namespace: cellular_component def: "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos] subset: goslim_synapse synonym: "postsynaptic endocytic zone cytoplasmic component" EXACT [] is_a: GO:0099738 ! cell cortex region relationship: part_of GO:0098843 ! postsynaptic endocytic zone [Term] id: GO:0099632 name: protein transport within plasma membrane namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer relationship: occurs_in GO:0005886 ! plasma membrane [Term] id: GO:0099633 name: protein localization to postsynaptic specialization membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density)." [GOC:dos] synonym: "protein localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie] is_a: GO:0033365 ! protein localization to organelle is_a: GO:1903539 ! protein localization to postsynaptic membrane [Term] id: GO:0099634 name: postsynaptic specialization membrane namespace: cellular_component def: "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] subset: goslim_synapse is_a: GO:0097060 ! synaptic membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0045211 ! postsynaptic membrane intersection_of: part_of GO:0099572 ! postsynaptic specialization relationship: part_of GO:0045211 ! postsynaptic membrane relationship: part_of GO:0099572 ! postsynaptic specialization [Term] id: GO:0099635 name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels namespace: molecular_function def: "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission" [GOC:dos] subset: goslim_synapse is_a: GO:0099626 ! voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration relationship: part_of GO:0099703 ! induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration [Term] id: GO:0099636 name: cytoplasmic streaming namespace: biological_process def: "The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains." [GOC:dos, Wikipedia:Cytoplasmic_streaming&oldid=706214009] xref: Wikipedia:Cytoplasmic_streaming is_a: GO:0016482 ! cytosolic transport [Term] id: GO:0099637 name: neurotransmitter receptor transport namespace: biological_process def: "The directed movement of neurotransmitter receptors." [GOC:dos] subset: goslim_synapse is_a: GO:0015031 ! protein transport is_a: GO:0031503 ! protein-containing complex localization [Term] id: GO:0099638 name: endosome to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles." [GOC:dos] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0061951 ! establishment of protein localization to plasma membrane is_a: GO:1990126 ! retrograde transport, endosome to plasma membrane [Term] id: GO:0099639 name: neurotransmitter receptor transport, endosome to plasma membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane is_a: GO:0099638 ! endosome to plasma membrane protein transport [Term] id: GO:0099640 name: axo-dendritic protein transport namespace: biological_process def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axonal protein transport" NARROW [] is_a: GO:0008088 ! axo-dendritic transport is_a: GO:0098840 ! protein transport along microtubule [Term] id: GO:0099641 name: anterograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon cargo transport" BROAD [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport is_a: GO:1905383 ! protein localization to presynapse [Term] id: GO:0099642 name: retrograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" BROAD [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport [Term] id: GO:0099643 name: signal release from synapse namespace: biological_process def: "Any signal release from a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0023061 ! signal release intersection_of: GO:0023061 ! signal release intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse relationship: part_of GO:0099536 ! synaptic signaling [Term] id: GO:0099644 name: protein localization to presynaptic membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane." [GOC:dos] synonym: "protein localisation in presynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to presynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localization in presynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1905383 ! protein localization to presynapse is_a: GO:1990778 ! protein localization to cell periphery [Term] id: GO:0099645 name: neurotransmitter receptor localization to postsynaptic specialization membrane namespace: biological_process def: "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density)." [GOC:dos] subset: goslim_synapse synonym: "neurotransmitter receptor localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie] is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:0099633 ! protein localization to postsynaptic specialization membrane [Term] id: GO:0099646 name: neurotransmitter receptor transport, plasma membrane to endosome namespace: biological_process def: "Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome." [GOC:dos] subset: goslim_synapse is_a: GO:0036010 ! protein localization to endosome is_a: GO:0048227 ! plasma membrane to endosome transport is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0099637 ! neurotransmitter receptor transport [Term] id: GO:0099699 name: integral component of synaptic membrane namespace: cellular_component def: "The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0005887 ! integral component of plasma membrane is_a: GO:0099240 ! intrinsic component of synaptic membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0097060 ! synaptic membrane created_by: dos creation_date: 2017-05-25T17:22:18Z [Term] id: GO:0099703 name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration namespace: biological_process def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005] subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration intersection_of: positively_regulates GO:0016079 ! synaptic vesicle exocytosis relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane" [GOC:dos] synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0100001 name: regulation of skeletal muscle contraction by action potential namespace: biological_process def: "Any action potential process that regulates skeletal muscle contraction" [GOC:cjm, GOC:obol] is_a: GO:0001508 ! action potential is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0001508 ! action potential intersection_of: regulates GO:0003009 ! skeletal muscle contraction created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100002 name: negative regulation of protein kinase activity by protein phosphorylation namespace: biological_process def: "Any protein phosphorylation process that negatively_regulates protein kinase activity" [GOC:cjm, GOC:obol] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0006469 ! negative regulation of protein kinase activity intersection_of: GO:0006468 ! protein phosphorylation intersection_of: negatively_regulates GO:0004672 ! protein kinase activity created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100003 name: obsolete positive regulation of sodium ion transport by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates sodium ion transport" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100004 name: obsolete positive regulation of peroxisome organization by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates peroxisome organization" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100005 name: obsolete positive regulation of ethanol catabolic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates ethanol catabolic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100006 name: obsolete positive regulation of sulfite transport by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates sulfite transport" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100007 name: obsolete negative regulation of ceramide biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates ceramide biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100008 name: regulation of fever generation by prostaglandin biosynthetic process namespace: biological_process def: "Any prostaglandin biosynthetic process process that regulates fever generation" [GOC:cjm, GOC:obol] is_a: GO:0001516 ! prostaglandin biosynthetic process is_a: GO:0031620 ! regulation of fever generation intersection_of: GO:0001516 ! prostaglandin biosynthetic process intersection_of: regulates GO:0001660 ! fever generation created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100009 name: regulation of fever generation by prostaglandin secretion namespace: biological_process def: "Any prostaglandin secretion process that regulates fever generation" [GOC:cjm, GOC:obol] is_a: GO:0031620 ! regulation of fever generation is_a: GO:0032310 ! prostaglandin secretion intersection_of: GO:0032310 ! prostaglandin secretion intersection_of: regulates GO:0001660 ! fever generation created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100010 name: positive regulation of fever generation by prostaglandin biosynthetic process namespace: biological_process def: "Any prostaglandin biosynthetic process process that positively_regulates fever generation" [GOC:cjm, GOC:obol] is_a: GO:0031622 ! positive regulation of fever generation is_a: GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process intersection_of: GO:0001516 ! prostaglandin biosynthetic process intersection_of: positively_regulates GO:0001660 ! fever generation created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100011 name: positive regulation of fever generation by prostaglandin secretion namespace: biological_process def: "Any prostaglandin secretion process that positively_regulates fever generation" [GOC:cjm, GOC:obol] is_a: GO:0031622 ! positive regulation of fever generation is_a: GO:0100009 ! regulation of fever generation by prostaglandin secretion intersection_of: GO:0032310 ! prostaglandin secretion intersection_of: positively_regulates GO:0001660 ! fever generation created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100012 name: regulation of heart induction by canonical Wnt signaling pathway namespace: biological_process def: "Any canonical Wnt signaling pathway process that regulates heart induction" [GOC:cjm, GOC:obol] is_a: GO:0060070 ! canonical Wnt signaling pathway is_a: GO:0090381 ! regulation of heart induction intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: regulates GO:0003129 ! heart induction created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100013 name: obsolete positive regulation of fatty acid beta-oxidation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates fatty acid beta-oxidation" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100014 name: obsolete positive regulation of mating type switching by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates mating type switching" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100015 name: obsolete positive regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates inositol biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100016 name: obsolete regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates thiamine biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100017 name: obsolete negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates single organismal cell-cell adhesion" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100018 name: obsolete regulation of glucose import by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates glucose import" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100019 name: obsolete regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cAMP-mediated signaling" [GOC:cjm, GOC:obol] comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter. Consistent with this, there were no annotations to the term. https://github.com/geneontology/go-ontology/issues/14279 is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100020 name: regulation of transport by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that regulates transport" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0051049 ! regulation of transport intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006810 ! transport created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100021 name: regulation of iron ion transport by transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0100022 def: "Any transcription from RNA polymerase II promoter process that regulates iron ion transport" [GOC:cjm, GOC:obol] synonym: "regulation of iron ion import by transcription from RNA polymerase II promoter" RELATED [] is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0100020 ! regulation of transport by transcription from RNA polymerase II promoter intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006826 ! iron ion transport created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100023 name: obsolete regulation of meiotic nuclear division by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100024 name: obsolete regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100025 name: obsolete negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates cellular amino acid biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100026 name: positive regulation of DNA repair by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that positively_regulates DNA repair" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0045739 ! positive regulation of DNA repair intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0006281 ! DNA repair created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100027 name: obsolete regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cell separation after cytokinesis" [GOC:cjm, GOC:obol] is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100028 name: obsolete regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates conjugation with cellular fusion" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100029 name: obsolete regulation of histone modification by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone modification." [GOC:cjm, GOC:obol] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100030 name: obsolete regulation of histone acetylation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone acetylation." [GOC:cjm, GOC:obol] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100031 name: obsolete regulation of histone methylation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone methylation." [GOC:cjm, GOC:obol] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100032 name: obsolete positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates phospholipid biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100033 name: obsolete regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fungal-type cell wall biogenesis" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100034 name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates 4,6-pyruvylated galactose residue biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100035 name: obsolete negative regulation of transmembrane transport by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates transmembrane transport" [GOC:cjm, GOC:obol] comment: The term was obsoleted because it is better represented by a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100036 name: positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that positively_regulates purine nucleotide biosynthetic process" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100037 name: obsolete positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates cellular alcohol catabolic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100038 name: obsolete regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cellular response to oxidative stress" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100039 name: obsolete regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates pyrimidine nucleotide biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100040 name: obsolete negative regulation of invasive growth in response to glucose limitation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates invasive growth in response to glucose limitation" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100041 name: obsolete positive regulation of pseudohyphal growth by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates pseudohyphal growth" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100042 name: obsolete negative regulation of pseudohyphal growth by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates pseudohyphal growth" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100043 name: obsolete negative regulation of cellular response to alkaline pH by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates cellular response to alkaline pH" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100044 name: obsolete negative regulation of cellular hyperosmotic salinity response by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates cellular hyperosmotic salinity response" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100045 name: negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that negatively_regulates arginine catabolic process" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:1900082 ! negative regulation of arginine catabolic process intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: negatively_regulates GO:0006527 ! arginine catabolic process created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100046 name: obsolete positive regulation of arginine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates arginine biosynthetic process" [GOC:cjm, GOC:obol] comment: GO:0100046 is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100047 name: obsolete negative regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates inositol biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100048 name: obsolete positive regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates phosphatidylcholine biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100049 name: obsolete negative regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates phosphatidylcholine biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100050 name: obsolete negative regulation of mating type switching by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates mating type switching" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100051 name: obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates meiotic nuclear division" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100052 name: obsolete negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates G1/S transition of mitotic cell cycle" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100053 name: obsolete positive regulation of sulfate assimilation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates sulfate assimilation" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100054 name: positive regulation of flocculation via cell wall protein-carbohydrate interaction by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that positively_regulates flocculation via cell wall protein-carbohydrate interaction" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:1900479 ! positive regulation of flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100055 name: obsolete positive regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates phosphatidylserine biosynthetic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100056 name: negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that negatively_regulates phosphatidylserine biosynthetic process" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:1900469 ! negative regulation of phosphatidylserine biosynthetic process intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100057 name: regulation of phenotypic switching by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that regulates phenotypic switching" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0036166 ! phenotypic switching created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100058 name: obsolete positive regulation of phenotypic switching by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates phenotypic switching" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100059 name: obsolete negative regulation of phenotypic switching by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates phenotypic switching" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100060 name: obsolete negative regulation of SREBP signaling pathway by DNA binding namespace: molecular_function def: "OBSOLETE. Any DNA binding that negatively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100061 name: obsolete negative regulation of SREBP signaling pathway by transcription factor catabolic process namespace: biological_process def: "OBSOLETE. Any transcription factor catabolic process process that negatively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100062 name: obsolete positive regulation of SREBP signaling pathway by transcription factor catabolic process namespace: biological_process def: "OBSOLETE. Any transcription factor catabolic process process that positively_regulates SREBP signaling pathway" [GOC:cjm, GOC:obol] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100063 name: obsolete regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates dipeptide transmembrane transport" [GOC:cjm, GOC:obol] comment: The term was obsoleted because it is better represented by a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100064 name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates filamentous growth of a population of unicellular organisms in response to starvation" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100065 name: obsolete negative regulation of leucine import by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates leucine import" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100066 name: obsolete negative regulation of induction of conjugation with cellular fusion by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates induction of conjugation with cellular fusion" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100067 name: positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway namespace: biological_process def: "Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation" [GOC:cjm, GOC:obol] is_a: GO:0060070 ! canonical Wnt signaling pathway is_a: GO:1902831 ! positive regulation of spinal cord association neuron differentiation intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: positively_regulates GO:0021527 ! spinal cord association neuron differentiation created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100068 name: obsolete positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively_regulates pyrimidine-containing compound salvage" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100069 name: obsolete negative regulation of neuron apoptotic process by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively_regulates neuron apoptotic process" [GOC:cjm, GOC:obol] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0100070 name: regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter namespace: biological_process def: "Any transcription from RNA polymerase II promoter process that regulates fatty acid biosynthetic process" [GOC:cjm, GOC:obol] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0042304 ! regulation of fatty acid biosynthetic process intersection_of: GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0006633 ! fatty acid biosynthetic process created_by: cjm creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0101002 name: ficolin-1-rich granule namespace: cellular_component def: "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] synonym: "ficolin granule" RELATED [] synonym: "ficolin-1 rich granule" EXACT [] is_a: GO:0030141 ! secretory granule [Term] id: GO:0101003 name: ficolin-1-rich granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0070820 ! tertiary granule created_by: melanie [Term] id: GO:0101004 name: cytolytic granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the cytolytic granule." [PMID:17272266, PMID:21247065] is_a: GO:0005765 ! lysosomal membrane created_by: mec creation_date: 2015-12-15T04:32:00Z [Term] id: GO:0101005 name: ubiquitinyl hydrolase activity namespace: molecular_function alt_id: GO:1904265 def: "Catalysis of the hydrolysis of ubiquitin from proteins and other molecules." [GOC:mec] comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. synonym: "deubiquitinase activity" EXACT [] synonym: "ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol" NARROW [] is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: mec creation_date: 2016-02-08T09:39:38Z [Term] id: GO:0101006 name: protein histidine phosphatase activity namespace: molecular_function alt_id: GO:0008969 def: "Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate" [GOC:mec] synonym: "phosphohistidine phosphatase activity" BROAD [] is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0101007 name: negative regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress created_by: GOC:mec [Term] id: GO:0101008 name: negative regulation of transcription from RNA polymerase II promoter in response to increased salt namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] is_a: GO:0101007 ! negative regulation of transcription from RNA polymerase II promoter in response to salt stress created_by: mec [Term] id: GO:0101010 name: pulmonary blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec] is_a: GO:0001974 ! blood vessel remodeling [Term] id: GO:0101011 name: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate." [GOC:mah, PMID:26422458] synonym: "inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity" EXACT [] is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0101012 name: inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate + H2O = myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + phosphate." [GOC:mah, PMID:26422458] synonym: "inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity" EXACT [] is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0101013 name: mechanosensitive voltage-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:21041530, PMID:26838316] synonym: "mechanically-modulated voltage-gated sodium channel activity" EXACT [] is_a: GO:0005248 ! voltage-gated sodium channel activity is_a: GO:0140135 ! mechanosensitive cation channel activity intersection_of: GO:0005248 ! voltage-gated sodium channel activity intersection_of: GO:0008381 ! mechanosensitive ion channel activity [Term] id: GO:0101014 name: [isocitrate dehydrogenase (NADP+)] phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate." [PMID:6292732] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] xref: MetaCyc:ICITDEHASE-KIN-PHOSPHA is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0101016 name: FMN-binding domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the FMN-binding domain of a protein." [PMID:15752726] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0101017 name: regulation of mitotic DNA replication initiation from late origin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] synonym: "regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029] is_a: GO:1903466 ! regulation of mitotic DNA replication initiation created_by: mec [Term] id: GO:0101018 name: negative regulation of mitotic DNA replication initiation from late origin namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] synonym: "negative regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029] is_a: GO:0101017 ! regulation of mitotic DNA replication initiation from late origin is_a: GO:1903467 ! negative regulation of mitotic DNA replication initiation created_by: mec [Term] id: GO:0101019 name: nucleolar exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] is_a: GO:0000176 ! nuclear exosome (RNase complex) intersection_of: GO:0000178 ! exosome (RNase complex) intersection_of: part_of GO:0005730 ! nucleolus relationship: part_of GO:0005730 ! nucleolus created_by: bhm [Term] id: GO:0101020 name: estrogen 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O." [GOC:BHF] synonym: "oestrogen 16-alpha-hydroxylase activity" EXACT [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0101021 name: estrogen 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O." [GOC:BHF, GOC:rl, PMID:14559847] synonym: "oestrogen 2-hydroxylase activity" EXACT [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0101023 name: vascular endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774] is_a: GO:0001935 ! endothelial cell proliferation [Term] id: GO:0101024 name: nuclear membrane organization involved in mitotic nuclear division namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane during mitotic nuclear division." [GOC:vw, PMID:15147872] comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. is_a: GO:0071763 ! nuclear membrane organization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0101025 name: nuclear membrane biogenesis namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0071763 ! nuclear membrane organization [Term] id: GO:0101026 name: nuclear membrane biogenesis involved in mitotic nuclear division namespace: biological_process def: "A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division." [GOC:vw, PMID:26869222] is_a: GO:0061024 ! membrane organization is_a: GO:0101025 ! nuclear membrane biogenesis is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0101027 name: optical nerve axon regeneration namespace: biological_process def: "The regrowth of axons of the optical nerve following their loss or damage." [GOC:pga, PMID:16699509] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0101028 name: positive regulation of liquid surface tension namespace: biological_process def: "Any process that activates or increases the surface tension of a liquid." [GOC:sl, PMID:20949060] synonym: "positive regulation of surface tension of a liquid" EXACT [] is_a: GO:0050828 ! regulation of liquid surface tension [Term] id: GO:0101029 name: negative regulation of liquid surface tension namespace: biological_process def: "Any process that prevents or reduces the surface tension of a liquid." [GOC:sl, PMID:20949060] synonym: "negative regulation of surface tension of a liquid" EXACT [] is_a: GO:0050828 ! regulation of liquid surface tension [Term] id: GO:0101030 name: tRNA-guanine transglycosylation namespace: biological_process def: "The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0101031 name: chaperone complex namespace: cellular_component def: "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] comment: An example of this is HSP90AB1 in human (P08238) in PMID:21855797 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0102001 name: isoleucine N-monooxygenase (oxime forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.39] xref: EC:1.14.14.39 xref: MetaCyc:1.14.13.117-RXN xref: RHEA:28602 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102002 name: valine N-monooxygenase (oxime forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.38] xref: EC:1.14.14.38 xref: MetaCyc:1.14.13.118-RXN xref: RHEA:28606 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102003 name: Delta8-sphingolipid desaturase activity namespace: molecular_function def: "Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.4] xref: EC:1.14.19.4 xref: MetaCyc:1.14.19.4-RXN is_a: GO:0052631 ! sphingolipid delta-8 desaturase activity [Term] id: GO:0102004 name: 2-octaprenyl-6-hydroxyphenol methylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [EC:2.1.1.222] xref: MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN is_a: GO:1990888 ! 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity [Term] id: GO:0102006 name: 4-methyl-2-oxopentanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-] xref: MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102007 name: acyl-L-homoserine-lactone lactonohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine." [EC:3.1.1.81] xref: EC:3.1.1.81 xref: MetaCyc:3.1.1.81-RXN xref: Reactome:R-HSA-8932633 "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE" is_a: GO:0046573 ! lactonohydrolase activity [Term] id: GO:0102008 name: cytosolic dipeptidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a dipeptide <=> 2 a standard alpha amino acid that occurs in the cytosol" [EC:3.4.13.18] xref: EC:3.4.13.18 xref: MetaCyc:3.4.13.18-RXN is_a: GO:0016805 ! dipeptidase activity [Term] id: GO:0102009 name: proline dipeptidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid." [EC:3.4.13.9] xref: EC:3.4.13.9 xref: MetaCyc:3.4.13.9-RXN is_a: GO:0016805 ! dipeptidase activity [Term] id: GO:0102013 name: ATPase-coupled L-glutamate tranmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)." [EC:7.4.2.1] synonym: "L-glutamate-importing ATPase activity" RELATED [] xref: MetaCyc:ABC-13-RXN is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity [Term] id: GO:0102014 name: beta-D-galactose-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [EC:3.6.3.17] xref: MetaCyc:ABC-18-RXN is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity [Term] id: GO:0102025 name: ATPase-coupled thiosulfate transmembrane transporter activity namespace: molecular_function alt_id: GO:0032146 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [EC:7.3.2.3, GOC:mlg, GOC:pz] comment: Merged, see https://github.com/geneontology/go-ontology/issues/14642 synonym: "thiosulfate transmembrane-transporting ATPase activity" RELATED [] synonym: "thiosulphate ABC transporter activity" EXACT [] xref: EC:7.3.2.3 xref: MetaCyc:ABC-7-RXN is_a: GO:0015117 ! thiosulfate transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0102027 name: S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine." [EC:2.1.1.163, GOC:pz] xref: MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102028 name: cystathionine gamma-synthase activity (acts on O-phosphohomoserine) namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate" [EC:2.5.1.-, GOC:pz] xref: MetaCyc:CYSPH-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102029 name: D-lactate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol" [EC:1.1.5.-, GOC:pz] xref: MetaCyc:DLACTDEHYDROGFAD-RXN is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0102030 name: dTDP-L-rhamnose synthetase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+" [EC:1.1.1.-, GOC:pz, MetaCyc:DTDPRHAMSYNTHMULTI-RXN] xref: MetaCyc:DTDPRHAMSYNTHMULTI-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102031 name: 4-acetamido-4,6-dideoxy-D-galactose transferase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP" [EC:2.4.1.325, GOC:pz] xref: EC:2.4.1.325 xref: MetaCyc:FUC4NACTRANS-RXN xref: RHEA:28759 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102033 name: fatty acid omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: long-chain fatty acid + NADPH + H+ + O2 = an omega-hydroxy-long-chain fatty acid + NADP+ + H2O." [EC:1.14.13.205, GOC:pz] comment: Changed label, definition and cross references, see https://github.com/geneontology/go-ontology/issues/14194 synonym: "cytochrome P450 fatty acid omega-hydroxylase activity" RELATED [] xref: MetaCyc:RXN-16394 xref: PMID:18544608 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102035 name: isobutyryl-CoA:FAD oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2" [EC:1.3.8.-, GOC:pz, MetaCyc:MEPROPCOA-FAD-RXN] xref: MetaCyc:MEPROPCOA-FAD-RXN is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102036 name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]" [EC:2.1.1.258, GOC:pz] xref: EC:2.1.1.258 xref: MetaCyc:METHCOCLTH-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102037 name: 4-nitrotoluene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O" [EC:1.14.13.-, GOC:pz, MetaCyc:R361-RXN] xref: MetaCyc:R361-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102038 name: 4-nitrobenzyl alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide" [EC:1.1.3.-, GOC:pz] xref: MetaCyc:R362-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0102039 name: alkylhydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide" [EC:1.8.1.-, GOC:pz] xref: MetaCyc:R4-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0102040 name: fumarate reductase (menaquinone) namespace: molecular_function def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone" [EC:1.3.5.4, GOC:pz] xref: EC:1.3.5.4 xref: MetaCyc:R601-RXN is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0102041 name: 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase namespace: molecular_function def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid" [EC:2.5.1.105, GOC:pz] xref: EC:2.5.1.105 xref: MetaCyc:RXN-10009 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102042 name: dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+" [EC:1.4.1.24, GOC:pz] xref: EC:1.4.1.24 xref: MetaCyc:RXN-10032 xref: RHEA:25956 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0102043 name: isopentenyl phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)" [EC:2.7.4.26, GOC:pz] xref: EC:2.7.4.26 xref: MetaCyc:RXN-10068 xref: RHEA:33963 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0102044 name: 3-chlorobenzoate-4,5-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor" [EC:1.14.12.-, GOC:pz] xref: MetaCyc:RXN-10421 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0102045 name: 3-chlorobenzoate-3,4-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor" [EC:1.14.12.-, GOC:pz] xref: MetaCyc:RXN-10422 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0102046 name: 3,4-dichlorobenzoate-4,5-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor" [EC:1.14.12.-, GOC:pz] xref: MetaCyc:RXN-10427 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0102047 name: indole-3-acetyl-glycine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10429 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102048 name: indole-3-acetyl-isoleucine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10430 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102049 name: indole-3-acetyl-methionine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10431 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102050 name: indole-3-acetyl-tyrosine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10432 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102051 name: indole-3-acetyl-tryptophan synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10433 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102052 name: indole-3-acetyl-proline synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10434 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102053 name: (-)-jasmonoyl-isoleucine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10435 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102054 name: maleylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate" [EC:3.7.1.-, GOC:pz] xref: MetaCyc:RXN-10447 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102055 name: 12-hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate" [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-10451 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0102056 name: 11-hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate" [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-10453 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0102057 name: jasmonoyl-valine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10457 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102058 name: jasmonoyl-leucine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10459 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102059 name: 2-cis,6-cis-farnesyl pyrophosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: prenyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphoric acid + 2-cis,6-cis-farnesyl diphosphate" [EC:2.5.1.92, GOC:pz] xref: EC:2.5.1.92 xref: MetaCyc:RXN-10481 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102060 name: endo-alpha-bergamontene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid" [EC:4.2.3.54, GOC:pz] xref: EC:4.2.3.54 xref: MetaCyc:RXN-10482 xref: RHEA:30471 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102061 name: endo-beta-bergamontene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid" [EC:4.2.3.53, GOC:pz] xref: EC:4.2.3.53 xref: MetaCyc:RXN-10483 xref: RHEA:30467 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102062 name: alpha-santalene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid" [EC:4.2.3.50, GOC:pz] xref: EC:4.2.3.50 xref: MetaCyc:RXN-10567 xref: RHEA:30463 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102063 name: beta-curcumene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-10598 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102064 name: gamma-curcumene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid" [EC:4.2.3.94, GOC:pz] xref: EC:4.2.3.94 xref: MetaCyc:RXN-10599 xref: RHEA:32031 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102065 name: patchoulene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-10602 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102066 name: alpha-patchoulene synthase activityy namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-10603 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102067 name: geranylgeranyl diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+" [EC:1.3.1.83, GOC:pz] xref: EC:1.3.1.83 xref: MetaCyc:RXN-10625 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102068 name: alpha-humulene 10-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O" [EC:1.14.14.113, GOC:pz] xref: EC:1.14.14.113 xref: MetaCyc:RXN-10628 xref: RHEA:32491 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102069 name: zerumbone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+" [EC:1.1.1.326, GOC:pz] xref: EC:1.1.1.326 xref: MetaCyc:RXN-10629 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102070 name: 18-hydroxyoleate peroxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol" [EC:1.11.-.-, GOC:pz] xref: MetaCyc:RXN-1064 is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0102071 name: 9,10-epoxy-18-hydroxystearate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate" [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-1065 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0102072 name: 3-oxo-cis-Delta9-hexadecenoyl-[acp] reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP + a 3R-hydroxy cis Delta9-hexadecenoyl-[acp] <=> NADPH + H+ + a 3-oxo-cis-Delta9-hexadecenoyl-[acp]" [EC:1.1.1.100, GOC:pz] xref: MetaCyc:RXN-10659 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102073 name: OPC8-trans-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA <=> OPC8-trans-2-enoyl-CoA + H2O" [EC:4.2.1.17, GOC:pz] xref: MetaCyc:RXN-10697 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102074 name: OPC6-trans-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA <=> OPC6-trans-2-enoyl-CoA + H2O" [EC:4.2.1.17, GOC:pz] xref: MetaCyc:RXN-10704 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102075 name: OPC4-trans-2-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA <=> OPC4-trans-2-enoyl-CoA + H2O" [EC:4.2.1.17, GOC:pz] xref: MetaCyc:RXN-10705 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102076 name: beta,beta-carotene-9',10'-cleaving oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone" [EC:1.13.11.71, GOC:pz] xref: EC:1.13.11.71 xref: MetaCyc:RXN-10741 xref: RHEA:26389 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102077 name: oleamide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleamide + H2O <=> oleate + ammonium" [EC:3.5.1.99, GOC:pz] xref: EC:3.5.1.99 xref: MetaCyc:RXN-10756 xref: RHEA:26506 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0102078 name: methyl jasmonate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonic acid <=> S-adenosyl-L-homocysteine + a methyl jasmonate" [EC:2.1.1.141, GOC:pz] xref: EC:2.1.1.141 xref: MetaCyc:RXN-10768 xref: RHEA:13349 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102080 name: phenylacetyl-coenzyme A:glycine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A" [EC:2.3.1.192, GOC:pz] xref: EC:2.3.1.192 xref: MetaCyc:RXN-10821 xref: RHEA:27850 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102081 name: homotaurine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-)" [EC:2.6.1.-, GOC:pz] xref: MetaCyc:RXN-10822 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0102082 name: demethylrebeccamycin--D-glucose O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine" [EC:2.1.1.164, GOC:pz] xref: EC:2.1.1.164 xref: MetaCyc:RXN-10847 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102083 name: 7,8-dihydromonapterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol" [GOC:pz, PMID:15107504] xref: MetaCyc:RXN-10857 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0102084 name: L-dopa O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.6, GOC:pz] xref: EC:2.1.1.6 xref: MetaCyc:RXN-10870 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102085 name: N-(4-aminobenzoyl)-L-glutamate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10884 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102086 name: N-vanillate-L-glutamate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10885 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102087 name: N-benzoyl-L-glutamate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10886 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102088 name: N-(4-hydroxybenzoyl)-L-glutamate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-10887 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102089 name: dehydroscoulerine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+" [EC:1.21.3.-, GOC:pz] xref: MetaCyc:RXN-10888 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0102090 name: adrenaline O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.6, GOC:pz] xref: MetaCyc:RXN-10909 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102091 name: phosphatidylinositol-5-phosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = hydrogenphosphate + an L-1-phosphatidyl-inositol" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-10962 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102092 name: 5-diphosphoinositol pentakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP" [EC:2.7.4.24, GOC:pz] xref: EC:2.7.4.24 xref: MetaCyc:RXN-10979 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0102093 name: acrylate:acyl-coA CoA transferase activity namespace: molecular_function def: "Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-10985 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102094 name: S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol" [EC:2.1.1.163, GOC:pz] xref: MetaCyc:RXN-11046 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102096 name: decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+" [EC:2.4.1.289, GOC:pz] xref: EC:2.4.1.289 xref: MetaCyc:RXN-11070 xref: RHEA:34487 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102097 name: (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O" [EC:1.14.14.147, GOC:pz] xref: EC:1.14.14.147 xref: MetaCyc:RXN-11101 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102098 name: D-galacturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+" [EC:1.1.1.365, GOC:pz] xref: EC:1.1.1.365 xref: MetaCyc:RXN-11151 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102099 name: FAD-dependent urate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O" [EC:1.14.13.113, GOC:pz] xref: EC:1.14.13.113 xref: MetaCyc:RXN-11186 xref: RHEA:27329 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102100 name: mycothiol-arsenate ligase activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O" [EC:2.8.4.2, GOC:pz] xref: EC:2.8.4.2 xref: MetaCyc:RXN-11187 xref: RHEA:27349 is_a: GO:0050497 ! transferase activity, transferring alkylthio groups [Term] id: GO:0102101 name: sterol 24C methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 26,27-dehydrozymosterol + S-adenosyl-L-methionine <=> 24-alkyl sterol 1 + S-adenosyl-L-homocysteine" [EC:2.1.1.43, GOC:pz] xref: MetaCyc:RXN-11201 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102102 name: homocarnosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate" [EC:6.3.2.11, GOC:pz] xref: EC:6.3.2.11 xref: MetaCyc:RXN-11222 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0102103 name: demethoxycurcumin synthase namespace: molecular_function def: "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide" [EC:2.3.1.219, GOC:pz] xref: EC:2.3.1.219 xref: MetaCyc:RXN-11223 xref: RHEA:35119 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102104 name: demethoxycurcumin synthase activity namespace: molecular_function def: "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-11224 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102105 name: demethoxycurcumin synthase activity from feruloylacetyl-CoA namespace: molecular_function def: "Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide" [EC:2.3.1.219, GOC:pz] xref: EC:2.3.1.219 xref: MetaCyc:RXN-11225 xref: RHEA:35139 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102106 name: curcumin synthase activity namespace: molecular_function def: "Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide" [EC:2.3.1.217, GOC:pz] xref: EC:2.3.1.217 xref: MetaCyc:RXN-11226 xref: RHEA:34823 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102109 name: tricaffeoyl spermidine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11261 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102111 name: gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-113 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102113 name: hypoxia-inducible factor-asparagine oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O2 + a hypoxia inducible factor (HIF) alpha subunit = succinate + carbon dioxide + a (3S)-3-hydroxy-L-asparagine-HIF alpha subunit" [EC:1.14.11.30, GOC:pz] xref: EC:1.14.11.30 xref: MetaCyc:RXN-11321 xref: RHEA:54268 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102114 name: caprate dehydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: decanoate + NADPH + O2 + H+ <=> 10-hydroxycaprate + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11325 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102115 name: peptidoglycan asparagine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid" [EC:6.3.1.-, GOC:pz] xref: MetaCyc:RXN-11338 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0102116 name: laurate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11340 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102117 name: gibberellin A9 carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine" [EC:2.1.1.275, GOC:pz] xref: EC:2.1.1.275 xref: MetaCyc:RXN-11358 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102118 name: gibberellin A4 carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine" [EC:2.1.1.276, GOC:pz] xref: EC:2.1.1.276 xref: MetaCyc:RXN-11359 xref: RHEA:36107 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102119 name: gibberellin A20 carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11360 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102121 name: ceramidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid" [EC:3.5.1.23, GOC:pz] xref: EC:3.5.1.23 xref: MetaCyc:RXN-11375 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0102122 name: gibberellin A34 carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11384 xref: RHEA:36127 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102123 name: gibberellin A4 16alpha,17 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-11385 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102124 name: gibberellin A12 16alpha,17 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-11387 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102125 name: gibberellin A9 16alpha,17 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-11388 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102126 name: coniferyl aldehyde 5-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-1142 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102127 name: 8-oxoguanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium" [EC:3.5.4.32, GOC:pz] xref: EC:3.5.4.32 xref: MetaCyc:RXN-11455 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0102128 name: chalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-11468 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102130 name: malonyl-CoA methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester" [EC:2.1.1.197, GOC:pz] xref: EC:2.1.1.197 xref: MetaCyc:RXN-11475 xref: RHEA:17105 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102131 name: 3-oxo-glutaryl-[acp] methyl ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP + a 3R-hydroxyglutaryl-[acp] methyl ester <=> NADPH + H+ + a 3-oxo-glutaryl-[acp] methyl ester" [EC:1.1.1.100, GOC:pz] xref: EC:1.1.1.100 xref: MetaCyc:RXN-11476 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102132 name: 3-oxo-pimeloyl-[acp] methyl ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP + a 3R-hydroxypimeloyl-[acp] methyl ester <=> NADPH + H+ + a 3-oxo-pimeloyl-[acp] methyl ester." [EC:1.1.1.100, GOC:pz] xref: EC:1.1.1.100 xref: MetaCyc:RXN-11480 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102133 name: limonene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11493 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102134 name: (22S)-22-hydroxy-campesterol C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11529 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102135 name: (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11530 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102136 name: 3-epi-6-deoxocathasterone C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + NADPH + O2 <=> 6-deoxotyphasterol + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11531 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102137 name: 7-oxateasterone synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11537 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102138 name: 7-oxatyphasterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11538 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102139 name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate." [EC:3.7.1.13, GOC:pz] xref: EC:3.7.1.13 xref: MetaCyc:RXN-11543 xref: RHEA:27870 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102140 name: heparan sulfate N-deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine" [EC:3.1.1.-, GOC:pz] xref: MetaCyc:RXN-11557 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102141 name: [chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate" [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-11560 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0102142 name: [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate" [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-11561 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0102143 name: carboxynorspermidine dehydrogenase I activity namespace: molecular_function def: "Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+" [EC:1.5.1.43, GOC:pz] xref: MetaCyc:RXN-11565 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0102144 name: carboxyspermidine dehydrogenase II activity namespace: molecular_function def: "Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+" [EC:1.5.1.43, GOC:pz] xref: MetaCyc:RXN-11566 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0102145 name: (3R)-(E)-nerolidol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid" [EC:4.2.3.49, GOC:pz] xref: EC:4.2.3.49 xref: MetaCyc:RXN-11575 xref: RHEA:27534 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102146 name: tricetin O-methytransferase activity namespace: molecular_function def: "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11582 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102147 name: 3'-O-methyltricetin O methyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11583 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102148 name: N-acetyl-beta-D-galactosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan" [EC:3.2.1.52, GOC:pz] xref: EC:3.2.1.52 xref: MetaCyc:RXN-11622 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102149 name: farnesylcysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide" [EC:1.8.3.6, GOC:pz] xref: EC:1.8.3.6 xref: MetaCyc:RXN-11623 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0102150 name: 3-oxo-myristoyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+" [EC:3.1.2.-, GOC:pz] xref: MetaCyc:RXN-11668 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102151 name: 3-oxo-myristate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide" [EC:4.1.1.56, GOC:pz] xref: EC:4.1.1.56 xref: MetaCyc:RXN-11669 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0102152 name: Delta12-linoleate epoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11671 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102154 name: 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-11685 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102155 name: S-sulfolactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+" [EC:1.1.1.310, GOC:pz] xref: EC:1.1.1.310 xref: MetaCyc:RXN-11689 xref: RHEA:28194 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102156 name: 2,5-DHBA UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-11705 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102157 name: (R)-sulfopropanediol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102158 name: very-long-chain 3-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain trans-2,3-dehydroacyl-CoA" [EC:4.2.1.134, GOC:pz] xref: EC:4.2.1.134 xref: MetaCyc:RXN-11750 xref: RHEA:45812 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102159 name: baicalein 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin" [EC:2.4.1.253, GOC:pz] xref: EC:2.4.1.253 xref: MetaCyc:RXN-11755 xref: RHEA:28314 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102160 name: cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP" [EC:2.4.1.254, GOC:pz] xref: EC:2.4.1.254 xref: MetaCyc:RXN-11756 xref: RHEA:28258 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102161 name: copal-8-ol diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O" [EC:4.2.1.133, GOC:pz] xref: EC:4.2.1.133 xref: MetaCyc:RXN-11772 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102162 name: all-trans-8'-apo-beta-carotenal 15,15'-oxygenase namespace: molecular_function def: "Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial" [EC:1.13.11.75, GOC:pz] xref: EC:1.13.11.75 xref: MetaCyc:RXN-11783 xref: RHEA:26385 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102163 name: 3-hydroxyacyl-CoA-acyl carrier protein transferase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-11785 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102164 name: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O" [EC:1.14.13.182, GOC:pz] xref: EC:1.14.13.182 xref: MetaCyc:RXN-11849 xref: RHEA:37871 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102165 name: (Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A" [EC:2.3.1.195, GOC:pz] xref: EC:2.3.1.195 xref: MetaCyc:RXN-11852 xref: RHEA:28254 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102166 name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine" [EC:3.2.1.169, GOC:pz] xref: EC:3.2.1.169 xref: MetaCyc:RXN-11891 xref: RHEA:48892 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102167 name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine" [EC:3.2.1.169, GOC:pz] xref: EC:3.2.1.169 xref: MetaCyc:RXN-11892 xref: RHEA:48876 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102168 name: 5-methyl-phenazine-1-carboxylate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11897 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102169 name: pyocyanin hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11898 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102170 name: 5-epi-aristolochene-1,3-dihydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O" [EC:1.14.14.149, GOC:pz] xref: EC:1.14.14.149 xref: MetaCyc:RXN-11908 xref: RHEA:28226 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102171 name: DMNT synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11911 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102172 name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11925 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102173 name: 24-methylenecycloartanol 4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11926 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102174 name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11927 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102175 name: 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD <=> cycloeucalenone + NADH + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11928 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102176 name: cycloeucalenone reductase activity namespace: molecular_function def: "Catalysis of the reaction: cycloeucalenone + NADPH + H+ <=> cycloeucalenol + NADP" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11929 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102177 name: 24-methylenelophenol methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11930 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102178 name: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11932 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102179 name: 24-ethylidenelophenol 4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11935 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102180 name: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11936 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102181 name: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11937 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102182 name: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11938 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102183 name: avenastenone reductase activity namespace: molecular_function def: "Catalysis of the reaction: avenastenone + NADPH + H+ <=> avenasterol + NADP" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11939 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102184 name: cycloartenol 4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11946 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102185 name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11947 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102186 name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11948 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102187 name: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) <=> 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11949 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102188 name: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11956 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102189 name: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11957 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102190 name: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11958 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102191 name: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11959 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102192 name: neryl-diphosphate:isopentenyl-diphosphate cistransferase activity namespace: molecular_function def: "Catalysis of the reaction: neryl diphosphate(3-) + isopentenyl diphosphate(3-) <=> diphosphoric acid + 2-cis,6-cis-farnesyl diphosphate(3-)" [EC:2.5.1.92, GOC:pz] xref: EC:2.5.1.92 xref: MetaCyc:RXN-11973 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102193 name: protein-ribulosamine 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine" [EC:2.7.1.172, GOC:pz] xref: EC:2.7.1.172 xref: MetaCyc:RXN-12003 xref: RHEA:48432 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0102194 name: protein-fructosamine 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine" [EC:2.7.1.171, GOC:pz] xref: EC:2.7.1.171 xref: MetaCyc:RXN-12005 xref: RHEA:59832 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0102195 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+" [EC:6.3.2.37, GOC:pz] xref: EC:6.3.2.37 xref: MetaCyc:RXN-12042 xref: RHEA:25273 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0102196 name: cortisol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-12085 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102197 name: vinylacetate caboxylester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate" [EC:3.1.1.-, GOC:pz] xref: MetaCyc:RXN-12087 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102198 name: L-idonate 5-dehydrogenase activity (NAD-dependent) namespace: molecular_function def: "Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+" [EC:1.1.1.366, GOC:pz] xref: EC:1.1.1.366 xref: MetaCyc:RXN-12107 xref: RHEA:21172 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102199 name: nitric oxide reductase activity (NAD(P)H-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H" [EC:1.7.1.14, GOC:pz] xref: EC:1.7.1.14 xref: MetaCyc:RXN-12112 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0102200 name: N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate" [EC:3.1.4.54, GOC:pz] xref: EC:3.1.4.54 xref: MetaCyc:RXN-12116 xref: RHEA:33159 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0102201 name: (+)-2-epi-prezizaene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-12117 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102202 name: soladodine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+" [EC:2.4.1.173, GOC:pz] xref: EC:2.4.1.173 xref: MetaCyc:RXN-12123 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102203 name: brassicasterol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+" [EC:2.4.1.173, GOC:pz] xref: EC:2.4.1.173 xref: MetaCyc:RXN-12125 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102205 name: cholesterol alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+" [EC:2.4.1.173, GOC:pz] synonym: "cholesterol allpha-glucosyltransferase activity" EXACT [] xref: EC:2.4.1.173 xref: MetaCyc:RXN-12127 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102207 name: very long chain fatty acid omega-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: behenate + NADPH + O2 + H+ = 22-hydroxydocosanoate + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-12155 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102208 name: 2-polyprenyl-6-hydroxyphenol methylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol" [EC:2.1.1.222, GOC:pz] xref: MetaCyc:RXN-12160 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102209 name: trans-permethrin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate" [EC:3.1.1.88, GOC:pz] xref: EC:3.1.1.88 xref: MetaCyc:RXN-12167 xref: RHEA:30283 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102210 name: rhamnogalacturonan endolyase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]" [EC:4.2.2.23, GOC:pz] xref: EC:4.2.2.23 xref: MetaCyc:RXN-12173 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0102211 name: unsaturated rhamnogalacturonyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose" [EC:3.2.1.172, GOC:pz] xref: EC:3.2.1.172 xref: MetaCyc:RXN-12174 xref: RHEA:30927 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102212 name: unsaturated chondroitin disaccharide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate" [EC:3.2.1.180, GOC:pz] xref: EC:3.2.1.180 xref: MetaCyc:RXN-12177 xref: RHEA:31647 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102213 name: in-chain hydroxy fatty acyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN-12184 is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0102214 name: omega-hydroxy fatty acyl-CoA synthetase activity. namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN-12185 is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0102215 name: thiocyanate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-12189 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102216 name: maltodextrin water dikinase namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin" [EC:2.7.9.4, GOC:pz] xref: EC:2.7.9.4 xref: MetaCyc:RXN-12201 is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0102217 name: 6-phosphoglucan, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin" [EC:2.7.9.5, GOC:pz] xref: EC:2.7.9.5 xref: MetaCyc:RXN-12202 xref: RHEA:10256 is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0102218 name: starch, H2O dikinase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin" [EC:2.7.9.4, GOC:pz] xref: EC:2.7.9.4 xref: MetaCyc:RXN-12203 is_a: GO:0050521 ! alpha-glucan, water dikinase activity [Term] id: GO:0102219 name: phosphogluco-amylopectin water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin" [EC:2.7.9.5, GOC:pz] xref: EC:2.7.9.5 xref: MetaCyc:RXN-12204 is_a: GO:0051752 ! phosphoglucan, water dikinase activity [Term] id: GO:0102220 name: hydrogenase activity (NAD+, ferredoxin) namespace: molecular_function def: "Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin" [EC:1.12.1.4, GOC:pz] xref: EC:1.12.1.4 xref: MetaCyc:RXN-12215 xref: RHEA:30279 is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor [Term] id: GO:0102222 name: 6-phosophogluco-3-phosphogluco-starch phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: m+q H2O + a 6-phosphogluco-3-phosphogluco-amylopectin <=> m+q hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-12218 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102223 name: 4,4'-diapophytoene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2" [EC:1.3.8.2, GOC:pz] xref: EC:1.3.8.2 xref: MetaCyc:RXN-12224 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102224 name: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-12236 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102225 name: 4,4'-diaponeurosporene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2" [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-12258 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102229 name: amylopectin maltohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose" [EC:3.2.1.2, GOC:pz] xref: EC:3.2.1.2 xref: MetaCyc:RXN-12278 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102232 name: acrolein reductase activity namespace: molecular_function def: "Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-12281 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102233 name: crotonaldehyde redutase activity namespace: molecular_function def: "Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP." [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-12292 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102234 name: but-1-en-3-one reductase activity namespace: molecular_function def: "Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-12293 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102235 name: 1-penten-3-one reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-12295 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102236 name: trans-4-hexen-3-one reductase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-12296 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102237 name: ATP-dependent farnesol kinase activity namespace: molecular_function def: "Catalysis of the reaction: (2-trans,6-trans)-farnesol + ATP(4-) <=> H+ + 2-trans,-6-trans-farnesyl monophosphate + ADP(3-)" [EC:2.7.1.-, GOC:pz] xref: MetaCyc:RXN-12304 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0102238 name: geraniol kinase activity (ATP-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+" [EC:2.7.1.-, GOC:pz] xref: MetaCyc:RXN-12307 is_a: GO:0052670 ! geraniol kinase activity [Term] id: GO:0102240 name: soyasapogenol B glucuronide galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III" [EC:2.4.1.272, GOC:pz] xref: EC:2.4.1.272 xref: MetaCyc:RXN-12319 xref: RHEA:31487 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102241 name: soyasaponin III rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I" [EC:2.4.1.273, GOC:pz] xref: EC:2.4.1.273 xref: MetaCyc:RXN-12320 xref: RHEA:31491 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102243 name: ATP:geranylgeraniol phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (E,E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP" [EC:2.7.1.-, GOC:pz] xref: MetaCyc:RXN-12325 is_a: GO:0052671 ! geranylgeraniol kinase activity [Term] id: GO:0102244 name: 3-aminopropanal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH" [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-12332 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102245 name: lupan-3beta,20-diol synthase activity namespace: molecular_function def: "Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O" [EC:4.2.1.128, GOC:pz] xref: EC:4.2.1.128 xref: MetaCyc:RXN-12338 xref: RHEA:31351 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102246 name: 6-amino-6-deoxyfutalosine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine." [EC:3.2.2.30, GOC:pz] xref: EC:3.2.2.30 xref: MetaCyc:RXN-12346 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0102247 name: malonyl-malonyl acyl carrier protein-condensing enzyme activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12361 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102248 name: diacylglycerol transacylase activity namespace: molecular_function def: "Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12383 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102249 name: phosphatidylcholine:diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine" [EC:2.7.8.-, GOC:pz] xref: MetaCyc:RXN-12386 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0102250 name: linear malto-oligosaccharide phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide" [EC:2.4.1.1, GOC:pz] xref: EC:2.4.1.1 xref: MetaCyc:RXN-12392 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102251 name: all-trans-beta-apo-10'-carotenal cleavage oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial" [EC:1.13.11.70, GOC:pz] xref: EC:1.13.11.70 xref: MetaCyc:RXN-12393 xref: RHEA:26401 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102252 name: cellulose 1,4-beta-cellobiosidase activity (reducing end) namespace: molecular_function def: "Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains." [EC:3.2.1.176, GOC:pz] xref: EC:3.2.1.176 xref: MetaCyc:RXN-12420 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102253 name: neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside." [EC:3.2.1.159, GOC:pz] xref: EC:3.2.1.159 xref: MetaCyc:RXN-12426 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102254 name: neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose." [EC:3.2.1.159, GOC:pz] xref: EC:3.2.1.159 xref: MetaCyc:RXN-12427 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102255 name: neo-lambda-carrahexaose hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose" [EC:3.2.1.162, GOC:pz] xref: EC:3.2.1.162 xref: MetaCyc:RXN-12428 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102256 name: neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity namespace: molecular_function def: "Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose." [EC:3.2.1.159, GOC:pz] xref: EC:3.2.1.159 xref: MetaCyc:RXN-12429 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102257 name: 1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+" [EC:3.1.1.32, GOC:pz] xref: MetaCyc:RXN-12430 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102258 name: 1,3-diacylglycerol acylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid" [EC:3.1.1.-, GOC:pz] xref: MetaCyc:RXN-12433 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102259 name: 1,2-diacylglycerol acylhydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid" [EC:3.1.1.-, GOC:pz] xref: MetaCyc:RXN-12434 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102260 name: germacrene A alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP + H2O <=> germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+" [EC:1.1.1.314, GOC:pz] xref: EC:1.1.1.314 xref: MetaCyc:RXN-12449 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102261 name: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420" [EC:1.5.1.40, GOC:pz] xref: EC:1.5.1.40 xref: MetaCyc:RXN-12450 xref: RHEA:31363 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0102262 name: tRNA-dihydrouridine16 synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) <=> H+ + a uracil16 in tRNA + NAD(P)H" [EC:1.3.1.88, GOC:pz] xref: MetaCyc:RXN-12454 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102263 name: tRNA-dihydrouridine17 synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) <=> H+ + a uracil17 in tRNA + NAD(P)H" [EC:1.3.1.88, GOC:pz] xref: EC:1.3.1.88 xref: MetaCyc:RXN-12455 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102264 name: tRNA-dihydrouridine20 synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) <=> H+ + a uracil20 in tRNA + NAD(P)H" [EC:1.3.1.91, GOC:pz] xref: EC:1.3.1.91 xref: MetaCyc:RXN-12456 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102265 name: tRNA-dihydrouridine47 synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H" [EC:1.3.1.89, GOC:pz] xref: EC:1.3.1.89 xref: MetaCyc:RXN-12457 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102266 name: tRNA-dihydrouridine20a synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) <=> H+ + a uracil20a in tRNA + NAD(P)H" [EC:1.3.1.90, GOC:pz] xref: EC:1.3.1.90 xref: MetaCyc:RXN-12475 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102267 name: tRNA-dihydrouridine20b synthase activity namespace: molecular_function def: "Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) <=> H+ + a uracil20b in tRNA + NAD(P)H" [EC:1.3.1.90, GOC:pz] xref: MetaCyc:RXN-12476 is_a: GO:0017150 ! tRNA dihydrouridine synthase activity [Term] id: GO:0102272 name: homophytochelatin synthase activity (polymer-forming) namespace: molecular_function def: "Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine" [EC:2.3.2.-, GOC:pz] xref: MetaCyc:RXN-12528 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0102273 name: homophytochelatin synthase (dimmer forming) activity namespace: molecular_function def: "Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine" [EC:2.3.2.-, GOC:pz] xref: MetaCyc:RXN-12529 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0102274 name: glutathione S-conjugate carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate" [EC:3.4.17.-, GOC:pz] xref: MetaCyc:RXN-12532 is_a: GO:0004181 ! metallocarboxypeptidase activity [Term] id: GO:0102275 name: cysteine-S-conjugate N-malonyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12534 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102276 name: 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O" [EC:1.13.12.19, GOC:pz] xref: EC:1.13.12.19 xref: MetaCyc:RXN-12538 xref: RHEA:31523 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0102277 name: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-12544 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102278 name: N,N'-diacetylchitobiose synthase activity namespace: molecular_function def: "Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-12554 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102279 name: lecithin:11-cis retinol acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine" [EC:2.3.1.135, GOC:pz] xref: EC:2.3.1.135 xref: MetaCyc:RXN-12563 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102280 name: choline monooxygenase activity (NADP-dependent) namespace: molecular_function def: "Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-12582 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102281 name: formylaminopyrimidine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate" [EC:3.5.1.-, GOC:pz] xref: MetaCyc:RXN-12612 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0102282 name: 3-ketodihydrosphinganine (C18) reductase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(1-) + a sphinganine <=> 3-dehydrosphinganinium(1+) + NADH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-12641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102283 name: 3-ketodihydrosphinganine (C20) reductase activity namespace: molecular_function def: "Catalysis of the reaction: C20 sphinganine(1+) + NADP <=> C20 3-dehydrosphinganine(1+) + NADPH + H+" [EC:1.1.1.102, GOC:pz] xref: MetaCyc:RXN-12642 xref: RHEA:22640 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102284 name: L-threo-sphinganine reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-threo-sphinganine + NADP <=> H+ + NADPH + 3-dehydrosphinganinium(1+)" [EC:1.1.1.102, GOC:pz] xref: MetaCyc:RXN-12645 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102285 name: 1-deoxy-11-oxopentalenate oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP" [EC:1.14.13.170, GOC:pz] xref: EC:1.14.13.170 xref: MetaCyc:RXN-12654 xref: RHEA:34635 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102286 name: ornithine N-delta-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12667 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102287 name: 4-coumaroylhexanoylmethane synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12668 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102289 name: beta-amyrin 11-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP." [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12680 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102290 name: beta-amyrin monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP" [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12681 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102291 name: 11alpha-hydroxy-beta-amyrin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP" [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12682 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102292 name: 30-hydroxy-beta-amyrin 11-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-12683 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102293 name: pheophytinase b activity namespace: molecular_function def: "Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol." [EC:3.1.1.14, GOC:pz] xref: EC:3.1.1.14 xref: MetaCyc:RXN-12686 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102294 name: cholesterol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+" [EC:1.1.1.145, GOC:pz] xref: EC:1.1.1.145 xref: MetaCyc:RXN-12693 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102295 name: 4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12699 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102296 name: 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+." [EC:3.7.1.17, GOC:pz] xref: EC:3.7.1.17 xref: MetaCyc:RXN-12718 xref: RHEA:32035 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102297 name: selenate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid" [EC:2.7.7.4, GOC:pz] xref: MetaCyc:RXN-12720 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0102298 name: selenocystathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine" [EC:2.5.1.-, GOC:pz] xref: MetaCyc:RXN-12728 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102299 name: linolenate 9R-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate" [EC:1.13.11.61, GOC:pz] xref: EC:1.13.11.61 xref: MetaCyc:RXN-12759 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102300 name: linoleate 9R-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE" [EC:1.13.11.61, GOC:pz] xref: EC:1.13.11.61 xref: MetaCyc:RXN-12760 xref: RHEA:31691 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102301 name: gamma-linolenate elongase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-12777 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102302 name: mycinamicin VI 2''-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+." [EC:2.1.1.238, GOC:pz] xref: EC:2.1.1.238 xref: MetaCyc:RXN-12801 xref: RHEA:31643 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102303 name: resveratrol 3,5-O-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+" [EC:2.1.1.240, GOC:pz] xref: EC:2.1.1.240 xref: MetaCyc:RXN-12805 xref: RHEA:32103 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102304 name: sesquithujene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid." [EC:4.2.3.102, GOC:pz] xref: EC:4.2.3.102 xref: MetaCyc:RXN-12838 xref: RHEA:31991 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102305 name: (13E)-labda-7,13-dien-15-ol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid" [EC:3.1.7.10, GOC:pz] xref: EC:3.1.7.10 xref: MetaCyc:RXN-12892 is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0102306 name: benzil reductase [(S)-benzoin-forming] activity namespace: molecular_function def: "Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+" [EC:1.1.1.320, GOC:pz] xref: EC:1.1.1.320 xref: MetaCyc:RXN-12898 xref: RHEA:25968 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102307 name: erythromycin C 3''-o-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+" [EC:2.1.1.254, GOC:pz] xref: EC:2.1.1.254 xref: MetaCyc:RXN-12923 xref: RHEA:32647 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102308 name: erythromycin D 3''-o-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+" [EC:2.1.1.254, GOC:pz] xref: EC:2.1.1.254 xref: MetaCyc:RXN-12924 xref: RHEA:32651 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102309 name: dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-D-oliose + NADP <=> dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-12930 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102310 name: dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H" [EC:1.17.1.-, GOC:pz] xref: MetaCyc:RXN-12940 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0102311 name: 8-hydroxygeraniol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+" [EC:1.1.1.324, GOC:pz] xref: EC:1.1.1.324 xref: MetaCyc:RXN-12961 xref: RHEA:32659 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102312 name: 4-coumaroyl 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-12963 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102313 name: 1,8-cineole synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid" [EC:4.2.3.108, GOC:pz] xref: EC:4.2.3.108 xref: MetaCyc:RXN-12980 xref: RHEA:32543 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102316 name: L-dopa oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-dopa + 0.5 O2 = L-dopaquinone + H2O" [EC:1.10.3.-, GOC:pz] xref: MetaCyc:RXN-13061 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0102317 name: 4-methylaminobutyrate oxidase (demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide" [EC:1.5.3.19, GOC:pz] xref: EC:1.5.3.19 xref: MetaCyc:RXN-13067 xref: RHEA:33907 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0102318 name: 2-deoxystreptamine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+" [EC:2.4.1.284, GOC:pz] xref: EC:2.4.1.284 xref: MetaCyc:RXN-13121 xref: RHEA:34063 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102319 name: 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-)" [EC:2.4.1.283, GOC:pz] xref: EC:2.4.1.283 xref: MetaCyc:RXN-13122 xref: RHEA:33947 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102320 name: 1,8-cineole 2-exo-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O" [EC:1.14.14.56, GOC:pz] xref: EC:1.14.14.56 xref: MetaCyc:RXN-13133 xref: RHEA:32895 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102321 name: 2,2'-hydroxybiphenyl monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD" [EC:1.14.13.44, GOC:pz] xref: EC:1.14.13.44 xref: MetaCyc:RXN-13150 xref: RHEA:11996 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102322 name: 2-propylphenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13151 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102323 name: 2-isopropylphenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13152 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102324 name: 2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+" [EC:3.7.1.-, GOC:pz] xref: MetaCyc:RXN-13157 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102325 name: 2,2',3-trihydroxybiphenyl monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13169 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102326 name: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+" [EC:3.7.1.8, GOC:pz] xref: MetaCyc:RXN-13171 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102327 name: 3-oxoacyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid" [EC:3.1.2.-, GOC:pz] xref: MetaCyc:RXN-13247 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102328 name: 3-oxoacid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone" [EC:4.1.1.-, GOC:pz] xref: MetaCyc:RXN-13248 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0102329 name: hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP <=> hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13251 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102330 name: palmitoyl-[acp] elongase/decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-13258 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102331 name: heptadecanoyl-[acp] elongase/decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-13259 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102332 name: fatty-acyl-[acp] elongase/decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-13260 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102333 name: stearoyl-[acp] elongase/decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-13261 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102334 name: N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity namespace: molecular_function def: "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP." [EC:2.7.8.36, GOC:pz] xref: EC:2.7.8.36 xref: MetaCyc:RXN-13269 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0102335 name: N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+." [EC:2.4.1.290, GOC:pz] xref: EC:2.4.1.290 xref: MetaCyc:RXN-13274 xref: RHEA:34511 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102336 name: 3-oxo-arachidoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A." [EC:2.3.1.199, GOC:pz] xref: EC:2.3.1.199 xref: MetaCyc:RXN-13294 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102337 name: 3-oxo-cerotoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A." [EC:2.3.1.199, GOC:pz] xref: EC:2.3.1.199 xref: MetaCyc:RXN-13296 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102338 name: 3-oxo-lignoceronyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A." [EC:2.3.1.199, GOC:pz] xref: EC:2.3.1.199 xref: MetaCyc:RXN-13297 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102339 name: 3-oxo-arachidoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) <=> 3-oxoicosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] xref: EC:1.1.1.330 xref: MetaCyc:RXN-13298 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102340 name: 3-oxo-behenoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] xref: EC:1.1.1.330 xref: MetaCyc:RXN-13299 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102341 name: 3-oxo-lignoceroyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP <=> 3-oxotetracosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] xref: EC:1.1.1.330 xref: MetaCyc:RXN-13300 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102342 name: 3-oxo-cerotoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP <=> 3-oxohexacosanoyl-CoA + NADPH + H+" [EC:1.1.1.330, GOC:pz] xref: EC:1.1.1.330 xref: MetaCyc:RXN-13301 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102343 name: 3-hydroxy-arachidoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA <=> trans-2-icosenoyl-CoA + H2O" [EC:4.2.1.134, GOC:pz] xref: EC:4.2.1.134 xref: MetaCyc:RXN-13302 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102344 name: 3-hydroxy-behenoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA <=> trans-2-docosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz] xref: EC:4.2.1.134 xref: MetaCyc:RXN-13303 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102345 name: 3-hydroxy-lignoceroyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) <=> trans-2-tetracosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz] xref: EC:4.2.1.134 xref: MetaCyc:RXN-13304 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102346 name: 3-hydroxy-cerotoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) <=> trans-2-hexacosenoyl-CoA(4-) + H2O" [EC:4.2.1.134, GOC:pz] xref: MetaCyc:RXN-13305 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102347 name: trans-arachidon-2-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) <=> trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+" [EC:1.3.1.93, GOC:pz] xref: MetaCyc:RXN-13306 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102348 name: trans-docosan-2-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: behenoyl-CoA + NADP <=> trans-2-docosenoyl-CoA + NADPH + H+" [EC:1.3.1.93, GOC:pz] xref: MetaCyc:RXN-13307 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102349 name: trans-lignocero-2-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: tetracosanoyl-CoA + NADP <=> trans-2-tetracosenoyl-CoA + NADPH + H+" [EC:1.3.1.93, GOC:pz] xref: MetaCyc:RXN-13308 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102350 name: trans-cerot-2-enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) <=> trans-2-hexacosenoyl-CoA + NADPH + H+" [EC:1.3.1.93, GOC:pz] xref: MetaCyc:RXN-13309 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102351 name: gamma-aminobutyrate transaminase (glyoxylate dependent) activity namespace: molecular_function def: "Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine" [EC:2.6.1.96, GOC:pz] xref: EC:2.6.1.96 xref: MetaCyc:RXN-13328 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0102352 name: phosphatidate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate" [EC:2.7.4.-, GOC:pz] xref: MetaCyc:RXN-13336 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0102353 name: multiradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate <=> miltiradiene + diphosphoric acid" [EC:4.2.3.131, GOC:pz] xref: EC:4.2.3.131 xref: MetaCyc:RXN-13338 xref: RHEA:33983 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102354 name: 11-cis-retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13363 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102355 name: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+" [EC:3.1.1.91, GOC:pz] xref: EC:3.1.1.91 xref: MetaCyc:RXN-13371 xref: RHEA:33967 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102356 name: isoitalicene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-13373 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102357 name: mithramycin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: mithramycin + NADP <=> mithramycin DK + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13385 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102358 name: daphnetin-8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13448 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102359 name: daphnetin 4-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+" [EC:2.4.1.126, GOC:pz] xref: EC:2.4.1.126 xref: MetaCyc:RXN-13450 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102360 name: daphnetin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+" [EC:2.4.1.91, GOC:pz] xref: EC:2.4.1.91 xref: MetaCyc:RXN-13452 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102361 name: esculetin 4-O-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+" [EC:2.4.1.126, GOC:pz] xref: EC:2.4.1.126 xref: MetaCyc:RXN-13471 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102362 name: esculetin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13472 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102363 name: isoscopoletin-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13475 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102365 name: taxusin 2-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13486 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102366 name: 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13487 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102367 name: 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13488 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102368 name: beta-amyrin 30-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13489 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102369 name: 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-13491 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102370 name: lupeol 28-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13497 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102371 name: betulin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-13498 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102372 name: alpha-amyrin 28-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13500 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102373 name: uvaol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-13501 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102374 name: ursolic aldehyde 28-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13502 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102375 name: 11-oxo-beta-amyrin 30-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O" [EC:1.14.14.115, GOC:pz] xref: EC:1.14.14.115 xref: MetaCyc:RXN-13506 xref: RHEA:35499 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102376 name: lupeol 28-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13507 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102377 name: steviol 13-O glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13511 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102378 name: steviolmonoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13512 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102379 name: steviolbioside glucosyltransferase activity (stevioside forming) namespace: molecular_function def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13514 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102380 name: steviolbioside glucosyltransferase activity (rebaudioside B forming) namespace: molecular_function def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13516 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102381 name: stevioside glucosyltransferase activity (rebaudioside A forming) namespace: molecular_function def: "Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13517 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102382 name: rebaudioside B glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13518 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102383 name: steviol 19-O glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13520 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102384 name: 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13521 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102385 name: patchoulol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-13522 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102386 name: phenylacetaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13536 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102387 name: 2-phenylethanol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A" [EC:2.3.1.224, GOC:pz] xref: EC:2.3.1.224 xref: MetaCyc:RXN-13542 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102388 name: UDP-N,N'-diacetylbacillosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+" [EC:3.2.1.184, GOC:pz] xref: EC:3.2.1.184 xref: MetaCyc:RXN-13574 xref: RHEA:34491 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102389 name: polyprenol reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol" [EC:1.3.1.94, GOC:pz] xref: EC:1.3.1.94 xref: MetaCyc:RXN-13604 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102390 name: mycophenolic acid acyl-glucuronide esterase activity namespace: molecular_function def: "Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate" [EC:3.1.1.93, GOC:pz] xref: EC:3.1.1.93 xref: MetaCyc:RXN-13605 xref: RHEA:34179 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102391 name: decanoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: decanoate + ATP(4-) + coenzyme A(4-) <=> decanoyl-CoA(4-) + AMP(2-) + diphosphoric acid" [EC:6.2.1.3, GOC:pz] xref: EC:6.2.1.3 xref: MetaCyc:RXN-13614 is_a: GO:0031956 ! medium-chain fatty acid-CoA ligase activity [Term] id: GO:0102392 name: decanoate-[HmqF protein] ligase activity namespace: molecular_function def: "Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN-13623 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0102393 name: decanoyl-[acp] 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein <=> FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF" [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-13624 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102394 name: 4-hydroxy-L-isoleucine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD <=> (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13637 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102395 name: 9-cis-beta-carotene 9',10'-cleavage oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone" [EC:1.13.11.68, GOC:pz] xref: EC:1.13.11.68 xref: MetaCyc:RXN-13642 xref: RHEA:34399 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102396 name: 9-cis-10'-apo-beta-carotenal cleavage oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal" [EC:1.13.11.69, GOC:pz] xref: EC:1.13.11.69 xref: MetaCyc:RXN-13643 xref: RHEA:34403 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102398 name: dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13657 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102399 name: dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13658 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102400 name: dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13667 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102402 name: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose" [EC:3.2.1.149, GOC:pz] xref: EC:3.2.1.149 xref: MetaCyc:RXN-13694 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102404 name: linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity namespace: molecular_function def: "Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool" [EC:3.2.1.149, GOC:pz] xref: EC:3.2.1.149 xref: MetaCyc:RXN-13701 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102405 name: (+)-taxifolin 5'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13718 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102406 name: omega-hydroxypalmitate O-sinapoyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate" [EC:2.3.1.188, GOC:pz] xref: EC:2.3.1.188 xref: MetaCyc:RXN-13728 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102407 name: sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate <=> coenzyme A + 2-C22:0-DCA-LPA" [EC:2.3.1.198, GOC:pz] xref: MetaCyc:RXN-13734 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102408 name: sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA" [EC:2.3.1.198, GOC:pz] xref: MetaCyc:RXN-13735 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102409 name: sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) <=> coenzyme A + 2-docosanoyl-glycerol 3-phosphate" [EC:2.3.1.198, GOC:pz] xref: MetaCyc:RXN-13736 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102410 name: quercetin-4',3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13765 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102411 name: quercetin-3,4'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13766 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102412 name: valerena-4,7(11)-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid" [EC:4.2.3.139, GOC:pz] xref: EC:4.2.3.139 xref: MetaCyc:RXN-13769 xref: RHEA:34467 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102413 name: 6-O-methyl-deacetylisoipecoside beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-13791 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102414 name: quercetin-3-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13797 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102415 name: quercetin gentiobioside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13798 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102416 name: quercetin gentiotrioside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13799 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102417 name: apigenin-7-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13800 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102418 name: luteolin-7-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13801 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102419 name: sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA" [EC:2.3.1.198, GOC:pz] xref: EC:2.3.1.198 xref: MetaCyc:RXN-13803 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102420 name: sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate" [EC:2.3.1.15, GOC:pz] xref: EC:2.3.1.15 xref: MetaCyc:RXN-13805 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102421 name: curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13813 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102422 name: curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13814 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102423 name: (+)-sesaminol 2-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13818 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102424 name: sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13821 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102425 name: myricetin 3-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP" [EC:2.4.1.91, GOC:pz] xref: EC:2.4.1.91 xref: MetaCyc:RXN-13822 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102426 name: myricetin-3-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13823 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102427 name: allocryptopine 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-13828 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102428 name: kaempferol-3-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13830 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102429 name: genistein-3-O-glucoside 1,6-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-13831 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102430 name: alpha-linolenate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-13857 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102431 name: linoleate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 + a reduced electron acceptor = pinolenate + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-13858 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102432 name: quercetin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13906 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102433 name: phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine" [EC:1.14.16.1, GOC:pz] xref: MetaCyc:RXN-13907 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102434 name: pterin-4alpha-carbinolamine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate" [GOC:pz, PMID:18245455, PMID:20959559] xref: MetaCyc:RXN-13908 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102435 name: myricetin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13910 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102436 name: 7-methylmyricetin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13911 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102437 name: myricetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 3-O-methylmyricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13912 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102438 name: laricitrin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13914 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102439 name: 3',4',5'-trimethylmyricetin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13916 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102440 name: 3',4',5'-trimethylmyricetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13918 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102441 name: syringetin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13919 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102442 name: syringetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13920 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102443 name: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate" [EC:1.1.1.337, GOC:pz] xref: EC:1.1.1.337 xref: MetaCyc:RXN-13927 xref: RHEA:34555 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102444 name: isorhamnetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13929 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102445 name: 3-methylquercetin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13930 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102446 name: rhamnetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13932 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102447 name: rhamnetin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13933 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102448 name: rhamnetin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13934 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102449 name: kaempferol 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13935 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102450 name: kaempferide 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13936 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102451 name: kaempferide 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-13937 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102452 name: bisdemethoxycurcumin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide" [EC:2.3.1.211, GOC:pz] xref: EC:2.3.1.211 xref: MetaCyc:RXN-13958 xref: RHEA:34803 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102453 name: anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]" [EC:2.3.1.215, GOC:pz] xref: EC:2.3.1.215 xref: MetaCyc:RXN-13959 xref: RHEA:35411 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102454 name: cyanidin 3-O-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP" [EC:2.4.1.294, GOC:pz] xref: EC:2.4.1.294 xref: MetaCyc:RXN-13960 xref: RHEA:35631 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102455 name: anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside" [EC:2.4.1.297, GOC:pz] xref: EC:2.4.1.297 xref: MetaCyc:RXN-13965 xref: RHEA:35419 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102456 name: cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+" [EC:2.4.1.299, GOC:pz] xref: MetaCyc:RXN-13967 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102457 name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate" [EC:2.4.1.300, GOC:pz] xref: EC:2.4.1.300 xref: MetaCyc:RXN-13969 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102458 name: cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+" [EC:2.4.1.299, GOC:pz] xref: EC:2.4.1.299 xref: MetaCyc:RXN-13970 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102459 name: 8-oxo-deoxyadenine diphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+" [EC:3.6.1.-, GOC:pz] xref: MetaCyc:RXN-14005 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102460 name: kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14008 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102461 name: kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14009 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102462 name: quercetin 3-sophoroside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14011 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102463 name: quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14012 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102464 name: zeaxanthin 2-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14016 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102465 name: zeaxanthin 2,2'-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14018 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102466 name: beta-carotene 2,2'-beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14019 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102467 name: scutellarein 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+" [EC:2.4.1.253, GOC:pz] xref: EC:2.4.1.253 xref: MetaCyc:RXN-14058 xref: RHEA:28318 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102468 name: wogonin 7-O-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+" [EC:2.4.1.253, GOC:pz] xref: EC:2.4.1.253 xref: MetaCyc:RXN-14060 xref: RHEA:28322 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102469 name: naringenin 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14069 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102470 name: 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14075 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102471 name: 2-hydroxynaringenin-6C-glucoside dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-14076 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102472 name: eriodictyol 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14077 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102473 name: eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14079 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102474 name: eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14080 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102475 name: 2-hydroxyeriodictyol 6C-glucoside dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-14081 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102476 name: pinocembrin 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14083 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102477 name: 2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-14088 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102478 name: beta-L-arabinofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose" [EC:3.2.1.185, GOC:pz] xref: EC:3.2.1.185 xref: MetaCyc:RXN-14089 xref: RHEA:36051 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102479 name: quercetin 3-O-beta:-D-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+" [EC:2.4.1.234, GOC:pz] xref: EC:2.4.1.234 xref: MetaCyc:RXN-14109 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102480 name: 5-fluorocytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium" [EC:3.5.4.1, GOC:pz] xref: EC:3.5.4.1 xref: MetaCyc:RXN-14129 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0102481 name: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+" [EC:3.7.1.22, GOC:pz] xref: EC:3.7.1.22 xref: MetaCyc:RXN-14149 xref: RHEA:25836 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0102482 name: 5-deoxy-D-glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate" [EC:5.3.1.30, GOC:pz] xref: EC:5.3.1.30 xref: MetaCyc:RXN-14150 xref: RHEA:25840 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0102483 name: scopolin beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin" [EC:3.2.1.21, GOC:pz] xref: EC:3.2.1.21 xref: MetaCyc:RXN-14179 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102484 name: esculetin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14182 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102485 name: dATP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14195 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102486 name: dCTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14198 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102487 name: dUTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14199 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102488 name: dTTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14200 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102489 name: GTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14201 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102490 name: 8-oxo-dGTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14205 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102491 name: dGTP phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+" [EC:3.6.1.5, GOC:pz] xref: EC:3.6.1.5 xref: MetaCyc:RXN-14208 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0102493 name: wogonin 7-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14239 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102494 name: GA20 2,3-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-14317 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102495 name: GA5 3beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-14318 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102496 name: GA5 2,3 epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-14327 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102497 name: scyllo-inositol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+" [EC:1.1.1.371, GOC:pz] xref: EC:1.1.1.371 xref: MetaCyc:RXN-14347 xref: RHEA:39063 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102498 name: maltose glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + maltose = 2 glucose" [GOC:pz, PMID:16343940] xref: MetaCyc:RXN-15910 is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0102499 name: SHG alpha-glucan phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan" [EC:2.4.1.1, GOC:pz] xref: EC:2.4.1.1 xref: MetaCyc:RXN-14353 xref: RHEA:41732 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102500 name: beta-maltose 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose" [EC:2.4.1.25, GOC:pz] xref: EC:2.4.1.25 xref: MetaCyc:RXN-14354 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102501 name: D-fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-14368 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102502 name: ADP-glucose-starch glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose" [EC:2.4.1.242, GOC:pz] xref: EC:2.4.1.242 xref: MetaCyc:RXN-14378 is_a: GO:0033840 ! NDP-glucose-starch glucosyltransferase activity [Term] id: GO:0102504 name: luteolinidin 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14424 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102505 name: apigeninidin 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-14427 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102506 name: cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+" [EC:2.4.1.299, GOC:pz] xref: EC:2.4.1.299 xref: MetaCyc:RXN-14432 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102507 name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+" [EC:2.4.1.300, GOC:pz] xref: EC:2.4.1.300 xref: MetaCyc:RXN-14434 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102508 name: cyanidin 3,7-diglucoside glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-14435 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102509 name: cyanidin 3,5-diglucoside glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-14436 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102510 name: pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+" [EC:2.4.1.299, GOC:pz] xref: EC:2.4.1.299 xref: MetaCyc:RXN-14439 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102511 name: pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+" [EC:2.4.1.300, GOC:pz] xref: EC:2.4.1.300 xref: MetaCyc:RXN-14440 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102512 name: delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+" [EC:2.4.1.299, GOC:pz] xref: EC:2.4.1.299 xref: MetaCyc:RXN-14441 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102513 name: delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+" [EC:2.4.1.300, GOC:pz] xref: MetaCyc:RXN-14442 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102514 name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+" [EC:2.4.1.300, GOC:pz] xref: EC:2.4.1.300 xref: MetaCyc:RXN-14446 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102515 name: pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+" [EC:2.4.1.300, GOC:pz] xref: MetaCyc:RXN-14447 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102516 name: delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+" [EC:2.4.1.300, GOC:pz] xref: MetaCyc:RXN-14448 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102517 name: oleate 12-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14487 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102518 name: (11Z)-eicosenoate 14-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14488 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102520 name: L-threonine O-3-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-14505 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102521 name: tRNA-4-demethylwyosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe" [EC:4.1.3.44, GOC:pz] xref: EC:4.1.3.44 xref: MetaCyc:RXN-14516 xref: RHEA:36347 is_a: GO:0016833 ! oxo-acid-lyase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0102522 name: tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe" [EC:2.5.1.114, GOC:pz] xref: EC:2.5.1.114 xref: MetaCyc:RXN-14518 xref: RHEA:36355 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0102523 name: 2-chloroacrylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+" [EC:1.3.1.103, GOC:pz] xref: EC:1.3.1.103 xref: MetaCyc:RXN-14536 xref: RHEA:36591 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102524 name: tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe" [EC:1.14.11.42, GOC:pz] xref: EC:1.14.11.42 xref: MetaCyc:RXN-14538 xref: RHEA:37899 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0102525 name: 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide" [EC:1.14.11.41, GOC:pz] xref: EC:1.14.11.41 xref: MetaCyc:RXN-14542 xref: RHEA:36607 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102526 name: 8-demethylnovobiocic acid C8-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+" [EC:2.1.1.284, GOC:pz] xref: EC:2.1.1.284 xref: MetaCyc:RXN-14543 xref: RHEA:36651 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102527 name: 8-demethylnovobiocate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid" [EC:6.3.1.15, GOC:pz] xref: EC:6.3.1.15 xref: MetaCyc:RXN-14547 xref: RHEA:36699 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0102528 name: 7,8,4'-trihydroxyflavone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-14658 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102529 name: apigenin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-14661 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102530 name: aclacinomycin T methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+" [EC:3.1.1.95, GOC:pz] xref: EC:3.1.1.95 xref: MetaCyc:RXN-14703 xref: RHEA:37891 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102531 name: ecdysteroid-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate <=> hydrogenphosphate + an ecdysteroid" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-14734 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102532 name: genkwanin 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14748 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102533 name: genkwanin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-14750 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102534 name: apigenin-7,4'-dimethyl ether 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14751 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102535 name: ladanein 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-14752 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102536 name: sakuranetin 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14754 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102537 name: ecdysone-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-14766 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102538 name: UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-14767 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102539 name: UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-14769 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102540 name: D-mannose 6-phosphate 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate" [EC:5.1.3.-, GOC:pz] xref: MetaCyc:RXN-14815 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0102541 name: D-galactose 6-phosphate 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate" [EC:5.1.3.-, GOC:pz] xref: MetaCyc:RXN-14816 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0102542 name: aclacinomycin A methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+" [EC:3.1.1.95, GOC:pz] xref: EC:3.1.1.95 xref: MetaCyc:RXN-14863 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102543 name: epsilon-rhodomycinone methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+" [EC:3.1.1.95, GOC:pz] xref: EC:3.1.1.95 xref: MetaCyc:RXN-14865 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102544 name: ornaline synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O" [EC:1.5.1.-, GOC:pz] xref: MetaCyc:RXN-14880 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0102545 name: phosphatidyl phospholipase B activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate" [EC:3.1.1.5, GOC:pz] xref: MetaCyc:RXN-14899 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102546 name: mannosylglycerate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate" [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-14900 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0102547 name: glucosylglycerate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate" [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-14901 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0102549 name: 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+" [EC:3.1.1.26, GOC:pz] xref: EC:3.1.1.26 xref: MetaCyc:RXN-14912 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102550 name: 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+" [EC:2.1.1.295, GOC:pz] xref: EC:2.1.1.295 xref: MetaCyc:RXN-14917 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102551 name: homogentisate geranylgeranyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide" [EC:2.5.1.116, GOC:pz] xref: EC:2.5.1.116 xref: MetaCyc:RXN-14929 xref: RHEA:38003 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102552 name: lipoyl synthase activity (acting on glycine-cleavage complex H protein namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]" [EC:2.8.1.8, GOC:pz] xref: MetaCyc:RXN-14950 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0102553 name: lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]" [EC:2.8.1.8, GOC:pz] xref: MetaCyc:RXN-14957 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0102554 name: lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]" [EC:2.8.1.8, GOC:pz] xref: MetaCyc:RXN-14959 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0102555 name: octanoyl transferase activity (acting on glycine-cleavage complex H protein) namespace: molecular_function def: "Catalysis of the reaction: [glycine cleavage system lipoyl-carrier protein]-L-lysine + OCTANOYL-ACP = H+ + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein]" [EC:2.3.1.181, GOC:pz] xref: EC:2.3.1.181 xref: MetaCyc:RXN-14966 xref: RHEA:17665 is_a: GO:0016415 ! octanoyltransferase activity [Term] id: GO:0102556 name: dammarenediol 12-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O" [EC:1.14.14.120, GOC:pz] xref: EC:1.14.14.120 xref: MetaCyc:RXN-14975 xref: RHEA:38579 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102557 name: protopanaxadiol 6-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O" [EC:1.14.14.121, GOC:pz] xref: EC:1.14.14.121 xref: MetaCyc:RXN-14978 xref: RHEA:22272 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102559 name: protein-(glutamine-N5) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine" [EC:2.1.1.297, GOC:pz] xref: EC:2.1.1.297 xref: MetaCyc:RXN-14992 xref: RHEA:42896 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102560 name: 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+." [EC:3.1.4.57, GOC:pz] synonym: "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase" EXACT [] xref: EC:3.1.4.57 xref: MetaCyc:RXN-14995 xref: RHEA:41612 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0102561 name: D-ribose 2,5-bisphosphate 2-phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate." [EC:3.1.4.57, GOC:pz] xref: EC:3.1.4.57 xref: MetaCyc:RXN-14996 xref: RHEA:41617 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0102562 name: hydroxyproline O-arbinofuranose transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline" [EC:2.4.2.-, GOC:pz] xref: MetaCyc:RXN-15011 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0102563 name: aurachin C monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15029 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102564 name: aurachin C epoxide hydrolase/isomerase activity namespace: molecular_function def: "Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)" [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-15030 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0102566 name: 1-acyl dihydroxyacetone phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP" [EC:1.1.1.101, GOC:pz] xref: EC:1.1.1.101 xref: MetaCyc:RXN-15046 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102567 name: phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+" [EC:3.1.1.4, GOC:pz] xref: EC:3.1.1.4 xref: MetaCyc:RXN-15065 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102568 name: phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:1-phosphatidylethanolamine + H2O = 1-oleoyl-sn-glycero-3-phosphoethanolamine + oleate + H+" [EC:3.1.1.4, GOC:pz] xref: EC:3.1.1.4 xref: MetaCyc:RXN-15067 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102569 name: FR-33289 synthase activity namespace: molecular_function def: "Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-15082 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102570 name: tyrosine:phenylpyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate" [EC:2.6.1.-, GOC:pz] xref: MetaCyc:RXN-15200 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0102571 name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)" [EC:3.2.1.169, GOC:pz] xref: EC:3.2.1.169 xref: MetaCyc:RXN-15215 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102572 name: N-glutamylanilide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+" [EC:3.5.1.-, GOC:pz] xref: MetaCyc:RXN-15251 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0102573 name: aminodeoxyfutalosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+" [EC:2.5.1.120, GOC:pz] xref: EC:2.5.1.120 xref: MetaCyc:RXN-15264 xref: RHEA:33075 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102574 name: 3-oxo-myristoyl-ACP hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]" [EC:3.1.2.-, GOC:pz] xref: MetaCyc:RXN-15280 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102575 name: 3-oxo-dodecanoyl-ACP hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]" [EC:3.1.2.-, GOC:pz] xref: MetaCyc:RXN-15281 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102576 name: 3-oxo-palmitoyl-ACP hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]" [EC:3.1.2.-, GOC:pz] xref: MetaCyc:RXN-15282 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102577 name: 3-oxo-palmitate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide" [EC:4.1.1.56, GOC:pz] xref: EC:4.1.1.56 xref: MetaCyc:RXN-15283 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0102580 name: cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP" [EC:2.4.2.51, GOC:pz] xref: EC:2.4.2.51 xref: MetaCyc:RXN-15326 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0102581 name: cyanidin 3-O-glucoside-p-coumaroyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15327 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102582 name: cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+." [EC:2.4.2.-, GOC:pz] xref: MetaCyc:RXN-15328 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0102583 name: cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15329 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102584 name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15330 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102585 name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15331 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102586 name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15332 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102587 name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15333 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102588 name: cyanidin 3-O-glucoside 6''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A." [EC:2.3.1.171, GOC:pz] xref: EC:2.3.1.171 xref: MetaCyc:RXN-15335 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102589 name: cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15336 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102590 name: delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15351 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102591 name: delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15352 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102592 name: delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15354 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102593 name: UDP-glucose: N-methylanthranilate glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15371 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102594 name: cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15372 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102595 name: cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15374 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102596 name: cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O" [EC:1.14.14.70, GOC:pz] xref: EC:1.14.14.70 xref: MetaCyc:RXN-15379 xref: RHEA:41464 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102597 name: 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O" [EC:1.14.14.122, GOC:pz] xref: EC:1.14.14.122 xref: MetaCyc:RXN-15381 xref: RHEA:41468 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102598 name: 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O" [EC:1.14.14.123, GOC:pz] xref: EC:1.14.14.123 xref: MetaCyc:RXN-15382 xref: RHEA:41472 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102599 name: cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15383 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102600 name: cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15384 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102601 name: cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 16beta-hydroxy-beta-amyrin + H2O + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15385 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102602 name: cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity namespace: molecular_function def: "Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15386 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102603 name: 12-demethyl-elloramycin C12a O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15402 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102604 name: naringenin,NADPH:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin(1-) + O2 + NADPH + H+ <=> 2-hydroxy-2,3-dihydrogenistein-7-olate + NADP + H2O" [EC:1.14.14.87, GOC:pz] xref: EC:1.14.14.87 xref: MetaCyc:RXN-1541 xref: RHEA:35487 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102605 name: cyclooctat-9-en-5,7-diol C18-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15430 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102606 name: octat-9-en-7-ol 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15431 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102607 name: 3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15433 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102608 name: tetracenomycin B3 8-O-methyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15435 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102609 name: 9-beta-stemod-13(17)-ene oxidase activity namespace: molecular_function def: "Catalysis of the reaction: stemod-13(17)-ene + 3 NADPH + 3 O2 + 3 H+ <=> 9beta-stemod-13(17)-en-19-oate + 3 NADP + 4 H2O" [EC:1.14.13.144, GOC:pz] xref: EC:1.14.13.144 xref: MetaCyc:RXN-15437 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102610 name: (+)-secoisolariciresinol glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15442 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102611 name: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-15443 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102612 name: syn-pimaradiene 6beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15452 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102613 name: trimethyluric acid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15454 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102614 name: germacrene A acid 8beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15460 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102615 name: ent-cassadiene-C2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15462 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102616 name: oryzalexin A synthase activity namespace: molecular_function def: "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin A + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15464 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102617 name: oryzalexin C synthase (oryzalexin B dependent) activity namespace: molecular_function def: "Catalysis of the reaction: oryzalexin B + NAD(P) <=> oryzalexin C + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15465 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102618 name: oryzalexin B synthase activity namespace: molecular_function def: "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin B + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15466 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102619 name: oryzalexin C synthase (oryzalexin A dependent) activity namespace: molecular_function def: "Catalysis of the reaction: oryzalexin A + NAD(P) <=> oryzalexin C + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15467 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102620 name: 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15495 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102621 name: emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity namespace: molecular_function def: "Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15496 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102622 name: linuron hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline" [EC:3.5.1.-, GOC:pz] xref: MetaCyc:RXN-15526 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0102623 name: scutellarein 7-methyl ether 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15528 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102624 name: scutellarein 7-methyl ether 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15529 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102625 name: cirsimaritin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15530 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102626 name: parthenolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15531 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102627 name: parthenolide 3beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15532 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102628 name: costunolide 3beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15533 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102629 name: patuletin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15534 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102630 name: gossypetin 8-methyl ester 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15536 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102631 name: caffeoylglucose 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-15537 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102632 name: (S)-nandinine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + NADPH + H+ + O2 <=> (S)-nandinine + NADP + 2 H2O" [GOC:pz] xref: MetaCyc:RXN-15538 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0102633 name: flaviolin monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15585 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102634 name: 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity namespace: molecular_function def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+" [EC:1.13.12.-, GOC:pz] xref: MetaCyc:RXN-15586 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0102635 name: 11-deoxycorticosterone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15607 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102636 name: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine <=> 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate" [EC:2.3.2.-, GOC:pz] xref: MetaCyc:RXN-15681 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0102637 name: 5-aminolevulinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN-15714 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0102638 name: [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid" [EC:2.5.1.105, GOC:pz] xref: EC:2.5.1.105 xref: MetaCyc:RXN-15734 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102639 name: paspalicine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15737 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102640 name: paspalinine synthase activity namespace: molecular_function def: "Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15738 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102641 name: (R)-lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15743 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102643 name: scalarane-17alpha-19-diol synthase activity namespace: molecular_function def: "Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-15755 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102644 name: monocyclic sesterterpenediol synthase activity namespace: molecular_function def: "Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-15756 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102645 name: 17(E)-cheilanthenediol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-15758 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102646 name: 14betaH-scalarane-17alpha-19-diol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O" [EC:4.2.1.-, GOC:pz] xref: MetaCyc:RXN-15759 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102647 name: D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate" [EC:2.2.1.-, GOC:pz] xref: MetaCyc:RXN-15789 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0102648 name: D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate" [EC:2.2.1.-, GOC:pz] xref: MetaCyc:RXN-15790 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0102649 name: acetoacetyl-ACP synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-15810 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102650 name: cyclo-acetoacetyl-L-tryptophan synthetase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]" [EC:6.3.2.-, GOC:pz] xref: MetaCyc:RXN-15811 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0102652 name: gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-171 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102653 name: gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-172 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102654 name: 1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-1725 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102655 name: 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-1726 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102656 name: 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-1727 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102657 name: 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-1728 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102658 name: 2-oxo-5-methylthiopentanoate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate" [EC:2.6.1.-, GOC:pz] xref: MetaCyc:RXN-2205 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0102659 name: UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXN-2208 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102660 name: caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity namespace: molecular_function def: "Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-2621 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102661 name: homogentisate solanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid" [EC:2.5.1.117, GOC:pz] xref: EC:2.5.1.117 xref: MetaCyc:RXN-2761 xref: RHEA:37995 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102662 name: malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-)" [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-2902 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102663 name: gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-292 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102664 name: indole-3-acetyl-leucine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-2945 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102665 name: indole-3-acetyl-glutamate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-2947 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102666 name: indole-3-acetyl-beta-4-D-glucose hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose" [EC:3.1.-.-, GOC:pz] xref: MetaCyc:RXN-3164 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0102667 name: indole-3-acetyl-beta-1-D-glucose hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose" [EC:3.1.-.-, GOC:pz] xref: MetaCyc:RXN-3165 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0102668 name: liquiritigenin,NADPH:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: liquiritigenin + NADPH + O2 + H+ <=> 2,4',7-trihydroxyisoflavanone + NADP(3-) + H2O" [EC:1.14.14.87, GOC:pz] xref: EC:1.14.14.87 xref: MetaCyc:RXN-3283 xref: RHEA:31723 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102669 name: isoflavone-7-O-glucoside beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-3591 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102670 name: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine" [EC:2.1.1.212, GOC:pz] xref: EC:2.1.1.212 xref: MetaCyc:RXN-3624 xref: RHEA:31371 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102671 name: 6a-hydroxymaackiain-3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine" [EC:2.1.1.270, GOC:pz] xref: EC:2.1.1.270 xref: MetaCyc:RXN-4002 xref: RHEA:35471 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102672 name: fatty acid alpha-oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid" [EC:1.13.11.-, GOC:pz] xref: MetaCyc:RXN-4121 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102673 name: fatty aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid" [EC:1.2.1.3, GOC:pz] xref: MetaCyc:RXN-4142 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102674 name: C4-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylenelophenol + a demethylated methyl acceptor <=> 9xi-episterol + a methylated methyl acceptor" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-4181 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102675 name: C4-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 24-ethylidenelophenol + a demethylated methyl acceptor <=> avenasterol + a methylated methyl acceptor" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-4208 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102676 name: avenasterol-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-4209 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102677 name: campesterol,NADPH:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-4225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102678 name: 22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-4229 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102679 name: (5alpha)-campestan-3-one hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-4230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102680 name: campest-4-en-3-one hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-4231 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102681 name: isoamylase (maltodextrin-releasing) activity namespace: molecular_function def: "Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin" [EC:3.2.1.68, GOC:pz] xref: MetaCyc:RXN-4301 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102682 name: N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate" [EC:3.2.2.-, GOC:pz] xref: MetaCyc:RXN-4313 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0102684 name: L-phenylalanine N-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide" [EC:1.14.14.40, GOC:pz] xref: EC:1.14.14.40 xref: MetaCyc:RXN-4602 xref: RHEA:33263 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102685 name: UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4721 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102686 name: UDP-glucose:trans-zeatin 9-N-glucosyltransferase namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4722 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102687 name: UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4724 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102688 name: dihydrozeatin UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4725 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102689 name: UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4727 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102690 name: isopentenyladenine UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4728 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102691 name: UDP-glucose:benzyladenine 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4729 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102692 name: benzyladenine UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4730 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102693 name: UDP-glucose:kinetin 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4731 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102694 name: kinetin UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4732 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102695 name: UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4733 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102696 name: cis-zeatin UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4734 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102697 name: trans-zeatin-O-glucoside UDP glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-4736 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102698 name: 5-epi-aristolochene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid" [EC:4.2.3.61, GOC:pz] xref: EC:4.2.3.61 xref: MetaCyc:RXN-4781 xref: RHEA:28635 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102699 name: 2-methylpropionitrile hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-5082 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102700 name: alpha-thujene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-5105 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102701 name: tricyclene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid" [EC:4.2.3.105, GOC:pz] xref: EC:4.2.3.105 xref: MetaCyc:RXN-5121 xref: RHEA:32687 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102702 name: 2-carene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-5122 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102703 name: camphene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid" [EC:4.2.3.117, GOC:pz] xref: EC:4.2.3.117 xref: MetaCyc:RXN-5142 xref: RHEA:25484 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102704 name: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol" [EC:2.4.1.257, GOC:pz] xref: EC:2.4.1.257 xref: MetaCyc:RXN-5463 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102705 name: serine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide" [EC:4.1.1.-, GOC:pz] xref: MetaCyc:RXN-5641 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0102706 name: butein:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+" [EC:1.21.3.6, GOC:pz] xref: EC:1.21.3.6 xref: MetaCyc:RXN-6242 xref: RHEA:34203 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0102707 name: S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine" [EC:2.1.1.49, GOC:pz] xref: EC:2.1.1.49 xref: MetaCyc:RXN-6461 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0102708 name: S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-6462 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0102709 name: S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-6464 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0102710 name: D-inositol-3-phosphate glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+" [EC:2.4.1.250, GOC:pz] xref: EC:2.4.1.250 xref: MetaCyc:RXN-6501 xref: RHEA:26188 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102711 name: gibberellin A25,oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6541 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102712 name: gibberellin A13,oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6542 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102713 name: gibberellin A25 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6543 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102714 name: gibberellin A12,oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6544 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102715 name: gibberellin A17,oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6546 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102716 name: gibberellin A28,oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-6547 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102717 name: DIBOA-glucoside oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide" [EC:1.14.11.59, GOC:pz] xref: EC:1.14.11.59 xref: MetaCyc:RXN-6685 xref: RHEA:32115 is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [Term] id: GO:0102718 name: TRIBOA-glucoside methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.241, GOC:pz] xref: EC:2.1.1.241 xref: MetaCyc:RXN-6687 xref: RHEA:32099 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102719 name: S-adenosyl-L-methionine:eugenol-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine" [EC:2.1.1.146, GOC:pz] xref: EC:2.1.1.146 xref: MetaCyc:RXN-6741 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102720 name: acetyl-coenzyme A:acetyl alcohol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A" [EC:2.3.1.224, GOC:pz] xref: EC:2.3.1.224 xref: MetaCyc:RXN-6762 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102721 name: ubiquinol:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone" [EC:1.10.3.11, GOC:pz] xref: EC:1.10.3.11 xref: MetaCyc:RXN-6883 xref: RHEA:30255 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0102722 name: gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-6903 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102723 name: UDP-glucose:curcumin glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-7062 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102724 name: UDP-glucose:curcumin monoglucoside glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-7063 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102725 name: 24-methyldesmosterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP" [EC:1.3.-.-, GOC:pz] xref: MetaCyc:RXN-708 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0102726 name: DIMBOA glucoside beta-D-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose" [EC:3.2.1.182, GOC:pz] xref: EC:3.2.1.182 xref: MetaCyc:RXN-7082 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102727 name: 3beta-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-710 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102728 name: campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-711 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102729 name: 6-oxocampestanol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-715 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102730 name: cathasterone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-716 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102731 name: D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP" [EC:2.7.1.-, GOC:pz] xref: MetaCyc:RXN-7185 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0102732 name: myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP" [EC:2.7.1.140, GOC:pz] xref: EC:2.7.1.140 xref: MetaCyc:RXN-7186 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0102733 name: typhasterol C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-719 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102734 name: brassinolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-720 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102735 name: trihydroxybenzophenone synthase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide" [EC:2.3.1.220, GOC:pz] xref: EC:2.3.1.220 xref: MetaCyc:RXN-7481 xref: RHEA:35143 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102737 name: p-coumaroyltriacetic acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-7577 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102738 name: (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-7589 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102739 name: (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-7591 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102740 name: theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine" [EC:2.1.1.160, GOC:pz] xref: EC:2.1.1.160 xref: MetaCyc:RXN-7599 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102741 name: paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine" [EC:2.1.1.160, GOC:pz] xref: EC:2.1.1.160 xref: MetaCyc:RXN-7601 xref: RHEA:10280 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102742 name: R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP" [EC:1.1.1.237, GOC:pz] xref: EC:1.1.1.237 xref: MetaCyc:RXN-7632 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102743 name: eriodictyol,NADPH:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7653 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102744 name: all-trans-geranyl-geranyl diphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7658 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102745 name: dihydrogeranylgeranyl-PP reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7659 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102746 name: tetrahydrogeranylgeranyl-PP reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7660 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102747 name: chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid" [EC:2.5.1.-, GOC:pz] xref: MetaCyc:RXN-7663 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102748 name: geranylgeranyl-chlorophyll a reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7664 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102749 name: dihydrogeranylgeranyl-chlorophyll a reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7665 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102750 name: tetrahydrogeranylgeranyl-chlorophyll a reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-7666 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102751 name: UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+" [EC:2.4.1.186, GOC:pz] xref: EC:2.4.1.186 xref: MetaCyc:RXN-7667 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102752 name: 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) namespace: molecular_function def: "Catalysis of the reaction: a glucosylated glycogenin = a glycogen" [EC:2.4.1.18, GOC:pz] xref: EC:2.4.1.18 xref: MetaCyc:RXN-7669 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102753 name: chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid" [EC:2.5.1.-, GOC:pz] xref: MetaCyc:RXN-7673 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102754 name: chlorophyllide-b:phytyl-diphosphate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid" [EC:2.5.1.-, GOC:pz] xref: MetaCyc:RXN-7674 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102755 name: gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-7680 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102756 name: very-long-chain 3-ketoacyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA" [EC:2.3.1.199, GOC:pz] xref: EC:2.3.1.199 xref: MetaCyc:RXN-7697 xref: RHEA:32727 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102757 name: NADPH phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-7703 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0102758 name: very-long-chain enoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA" [EC:1.3.1.93, GOC:pz] xref: EC:1.3.1.93 xref: MetaCyc:RXN-7711 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102759 name: campestanol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-773 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102760 name: 6-deoxocathasterone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-774 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102761 name: eriodictyol 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-7753 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102762 name: eriodictyol 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-7754 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102763 name: phytyl-P kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate" [EC:2.7.4.-, GOC:pz] xref: MetaCyc:RXN-7763 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0102764 name: 6-deoxotyphasterol C-23 hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor" [EC:1.14.-.-, GOC:pz] xref: MetaCyc:RXN-777 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0102765 name: UDP-D-apiose synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide" [EC:4.1.1.-, GOC:pz] xref: MetaCyc:RXN-7770 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0102766 name: naringenin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.232, GOC:pz] xref: EC:2.1.1.232 xref: MetaCyc:RXN-7773 xref: RHEA:31539 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102767 name: flavanone 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine" [EC:2.1.1.231, GOC:pz] xref: EC:2.1.1.231 xref: MetaCyc:RXN-7777 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102768 name: anthocyanidin synthase activity namespace: molecular_function def: "Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-7785 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102769 name: dihydroceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine" [EC:2.4.1.80, GOC:pz] xref: EC:2.4.1.80 xref: MetaCyc:RXN-7793 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102770 name: inositol phosphorylceramide synthase activity namespace: molecular_function def: "Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol" [EC:2.7.1.-, GOC:pz] xref: MetaCyc:RXN-7795 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0102771 name: sphingolipid very long chain fatty acid alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7796 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102772 name: sphingolipid long-chain base 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P)" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7797 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102773 name: dihydroceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate" [EC:2.7.1.138, GOC:pz] xref: EC:2.7.1.138 xref: MetaCyc:RXN-7799 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0102774 name: p-coumaroyltriacetic acid lactone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-7822 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102775 name: 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-7826 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102776 name: UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-7828 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102777 name: caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)" [EC:2.3.1.153, GOC:pz] xref: EC:2.3.1.153 xref: MetaCyc:RXN-7842 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102778 name: Delta9-tetrahydrocannabinolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide" [EC:1.21.3.7, GOC:pz] xref: EC:1.21.3.7 xref: MetaCyc:RXN-7854 xref: RHEA:34143 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0102779 name: cannabidiolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide" [EC:1.21.3.8, GOC:pz] xref: EC:1.21.3.8 xref: MetaCyc:RXN-7855 xref: RHEA:34411 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0102780 name: sitosterol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7876 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102781 name: isofucosterol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7877 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102782 name: cholestanol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7878 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102783 name: beta-carotene oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial" [EC:1.13.11.-, GOC:pz] xref: MetaCyc:RXN-7883 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102784 name: lutein oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial" [EC:1.13.11.-, GOC:pz] xref: MetaCyc:RXN-7884 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102785 name: violaxanthin oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial" [EC:1.13.11.-, GOC:pz] xref: MetaCyc:RXN-7886 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102786 name: stearoyl-[acp] desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin" [EC:1.14.19.2, GOC:pz] xref: EC:1.14.19.2 xref: MetaCyc:RXN-7903 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102787 name: caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-7997 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102788 name: 4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-7998 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102789 name: UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8005 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102790 name: cyanidin 5,3-O-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8006 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102791 name: sulfuretin synthase activity namespace: molecular_function def: "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O" [EC:1.21.3.6, GOC:pz] xref: EC:1.21.3.6 xref: MetaCyc:RXN-8008 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0102792 name: sinapaldehyde:NAD(P)+ oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH" [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-8014 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102793 name: soyasapogenol B glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate" [EC:2.4.1.262, GOC:pz] xref: EC:2.4.1.262 xref: MetaCyc:RXN-8086 xref: RHEA:31475 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102794 name: cinnamaldehyde:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide" [EC:1.2.3.9, GOC:pz] xref: EC:1.2.3.9 xref: MetaCyc:RXN-8089 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0102795 name: 1-naphthaldehyde:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide" [EC:1.2.3.9, GOC:pz] xref: EC:1.2.3.9 xref: MetaCyc:RXN-8090 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0102796 name: protocatechualdehyde:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide" [EC:1.2.3.9, GOC:pz] xref: EC:1.2.3.9 xref: MetaCyc:RXN-8091 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0102797 name: geranial:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide" [EC:1.2.3.1, GOC:pz] xref: EC:1.2.3.1 xref: MetaCyc:RXN-8093 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0102798 name: heptaldehyde:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide" [EC:1.2.3.1, GOC:pz] xref: EC:1.2.3.1 xref: MetaCyc:RXN-8094 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0102799 name: glucosinolate glucohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides." [EC:3.2.1.147, GOC:pz] xref: EC:3.2.1.147 xref: MetaCyc:RXN-8134 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102800 name: caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8138 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102801 name: anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A" [EC:2.3.1.214, GOC:pz] xref: EC:2.3.1.214 xref: MetaCyc:RXN-8139 xref: RHEA:35515 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102802 name: thebaine 6-O-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide" [EC:1.14.11.31, GOC:pz] xref: EC:1.14.11.31 xref: MetaCyc:RXN-8147 xref: RHEA:27477 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102803 name: thebane O-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide" [EC:1.14.11.32, GOC:pz] xref: EC:1.14.11.32 xref: MetaCyc:RXN-8149 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102804 name: oripavine 6-O-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide" [EC:1.14.11.31, GOC:pz] xref: EC:1.14.11.31 xref: MetaCyc:RXN-8151 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102805 name: codeine O-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide" [EC:1.14.11.32, GOC:pz] xref: EC:1.14.11.32 xref: MetaCyc:RXN-8152 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102806 name: 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8170 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102807 name: cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8176 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102808 name: pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8177 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102809 name: delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8178 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102810 name: glutarate-semialdehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+" [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-8182 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102811 name: geraniol 10-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O" [EC:1.14.14.83, GOC:pz] xref: EC:1.14.14.83 xref: MetaCyc:RXN-8197 xref: RHEA:32495 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102812 name: 4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8204 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102813 name: UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8205 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102814 name: caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8232 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102815 name: caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A" [EC:2.3.1.153, GOC:pz] xref: EC:2.3.1.153 xref: MetaCyc:RXN-8233 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102816 name: UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP" [EC:2.4.1.298, GOC:pz] xref: EC:2.4.1.298 xref: MetaCyc:RXN-8234 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102817 name: caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8235 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102818 name: lycopene cleavage oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde" [EC:1.13.12.-, GOC:pz] xref: MetaCyc:RXN-8236 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0102819 name: bixin aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+" [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-8237 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102820 name: norbixin methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8238 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102821 name: bixin methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8239 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102822 name: quercetin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine" [EC:2.1.1.42, GOC:pz] xref: EC:2.1.1.42 xref: MetaCyc:RXN-8262 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102823 name: kaempferol-3-rhamnoside-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8266 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102824 name: UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8267 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102825 name: quercetin 3-O-rhamnoside-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8268 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102826 name: kaempferol-3-glucoside-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8270 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102827 name: galactosylononitol-raffinose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol" [EC:2.4.1.67, GOC:pz] xref: MetaCyc:RXN-8282 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102828 name: stachyose galactinol:verbascose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8284 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102829 name: ajugose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8285 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102830 name: verbascose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8286 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102831 name: stachyose synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8287 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102832 name: verbascose galactinol:ajugose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8288 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102833 name: sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8292 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102834 name: 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8294 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102835 name: 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8295 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102836 name: 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8296 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102837 name: 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8297 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102838 name: 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8298 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102839 name: 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8299 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102840 name: 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8301 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102841 name: 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8302 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102842 name: 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8303 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102843 name: 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8304 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102844 name: 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8305 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102845 name: 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8307 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102846 name: 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8308 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102847 name: 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8309 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102848 name: 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8310 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102849 name: 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8314 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102850 name: 1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8316 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102851 name: 1-18:2-2-16:0-phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8318 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102852 name: 1-18:3-2-16:0-phosphatidylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8319 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102853 name: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8320 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102854 name: 1-18:2-2-18:1-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8321 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102855 name: 1-18:1-2-18:2-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8322 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102856 name: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8323 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102857 name: 1-18:1-2-18:3-phosphatidylcholinedesaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8324 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102858 name: 1-18:2-2-18:3-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8325 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102859 name: 1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8326 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102860 name: 1-18:1-2-18:2-phosphatidylcholine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:1-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8327 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102861 name: 1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8328 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102862 name: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming) namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8329 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102863 name: 1-18:3-2-18:1-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8330 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102864 name: 1-18:3-2-18:2-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8331 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102865 name: Delta6-acyl-lipid desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid gamma-linolenoyl group + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8343 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102866 name: di-homo-gamma-linolenate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8346 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102867 name: molybdenum cofactor sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O" [EC:2.8.1.9, GOC:pz] xref: EC:2.8.1.9 xref: MetaCyc:RXN-8351 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0102868 name: 24-epi-campsterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-8352 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102869 name: 6-hydroxyflavone-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8354 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102870 name: 7-hydroxyflavone-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8355 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102871 name: 1-16:0-2-18:1-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8360 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102872 name: 1-16:0-2-18:2-phosphatidylcholine desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8361 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102873 name: 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8363 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102874 name: 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8365 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102875 name: 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8366 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102876 name: psoralen synthase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O" [EC:1.14.14.141, GOC:pz] xref: EC:1.14.14.141 xref: MetaCyc:RXN-8386 xref: RHEA:19281 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102877 name: alpha-copaene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid" [EC:4.2.3.133, GOC:pz] xref: EC:4.2.3.133 xref: MetaCyc:RXN-8416 xref: RHEA:33991 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102878 name: (+)-alpha-barbatene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid" [EC:4.2.3.69, GOC:pz] xref: EC:4.2.3.69 xref: MetaCyc:RXN-8417 xref: RHEA:29499 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102879 name: (+)-thujopsene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid" [EC:4.2.3.79, GOC:pz] xref: EC:4.2.3.79 xref: MetaCyc:RXN-8418 xref: RHEA:30375 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102880 name: isobazzanene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8419 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102881 name: (+)-beta-barbatene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8421 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102882 name: beta-acoradiene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8423 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102883 name: (+)-beta-chamigrene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid" [EC:4.2.3.78, GOC:pz] xref: EC:4.2.3.78 xref: MetaCyc:RXN-8424 xref: RHEA:30379 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102884 name: alpha-zingiberene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid" [EC:4.2.3.65, GOC:pz] xref: EC:4.2.3.65 xref: MetaCyc:RXN-8425 xref: RHEA:28643 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102885 name: alpha-cuprenene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid" [EC:4.2.3.95, GOC:pz] xref: EC:4.2.3.95 xref: MetaCyc:RXN-8426 xref: RHEA:32027 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102886 name: alpha-chamigrene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8428 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102887 name: beta-sesquiphellandrene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid" [EC:4.2.3.123, GOC:pz] xref: EC:4.2.3.123 xref: MetaCyc:RXN-8430 xref: RHEA:32699 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102888 name: delta-cuprenene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8431 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102889 name: beta-elemene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8432 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102890 name: naringenin chalcone 4'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+" [EC:2.4.1.286, GOC:pz] xref: EC:2.4.1.286 xref: MetaCyc:RXN-8453 xref: RHEA:34291 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102891 name: 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP" [EC:2.4.1.286, GOC:pz] xref: EC:2.4.1.286 xref: MetaCyc:RXN-8455 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102892 name: betanidin 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8479 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102893 name: betanidin 6-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8480 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102894 name: UDPG:cyclo-DOPA 5-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8481 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102895 name: colneleate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O" [EC:4.2.1.121, GOC:pz] xref: EC:4.2.1.121 xref: MetaCyc:RXN-8496 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102896 name: colnelenate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O" [EC:4.2.1.121, GOC:pz] xref: MetaCyc:RXN-8498 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0102897 name: abietadienal hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8510 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102898 name: levopimaradienol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8517 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102899 name: dehydroabietadienol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8532 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102900 name: dehydroabietadienal hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8534 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102901 name: isopimaradienol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8536 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102902 name: isopimaradienal hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8538 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102903 name: gamma-terpinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid" [EC:4.2.3.114, GOC:pz] xref: EC:4.2.3.114 xref: MetaCyc:RXN-8547 xref: RHEA:32559 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102904 name: germacrene C synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid" [EC:4.2.3.60, GOC:pz] xref: EC:4.2.3.60 xref: MetaCyc:RXN-8561 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102905 name: valencene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid" [EC:4.2.3.73, GOC:pz] xref: EC:4.2.3.73 xref: MetaCyc:RXN-8608 xref: RHEA:29511 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102906 name: 7-epi-alpha-selinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid" [EC:4.2.3.86, GOC:pz] xref: EC:4.2.3.86 xref: MetaCyc:RXN-8609 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102907 name: sesquisabinene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8622 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102909 name: alpha-ketoglutarate reductase activity (NADH-dependent) namespace: molecular_function def: "Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-8645 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102910 name: dirigent protein activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O" [EC:1.10.3.-, GOC:pz] xref: MetaCyc:RXN-8677 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0102911 name: (-)-secoisolariciresinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-8680 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102912 name: (-)-lactol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-8681 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102913 name: 3-aminomethylindole N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8686 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102914 name: N-methyl-3-aminomethylindole N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8687 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102915 name: piperitol synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8695 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102916 name: sesamin synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8696 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102917 name: (S)-reticuline 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine." [EC:2.1.1.291, GOC:pz] xref: EC:2.1.1.291 xref: MetaCyc:RXN-8700 xref: RHEA:10444 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102918 name: (R)-reticuline 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.291, GOC:pz] xref: EC:2.1.1.291 xref: MetaCyc:RXN-8701 xref: RHEA:38907 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102919 name: 5,6-dimethylbenzimidazole synthase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid" [EC:1.13.11.79, GOC:pz] xref: EC:1.13.11.79 xref: MetaCyc:RXN-8771 xref: RHEA:27345 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0102920 name: acyl coenzyme A: isopenicillin N acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate" [EC:2.3.1.164, GOC:pz] xref: EC:2.3.1.164 xref: MetaCyc:RXN-8809 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102921 name: mannosylglycerate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP" [EC:2.4.1.269, GOC:pz] xref: EC:2.4.1.269 xref: MetaCyc:RXN-8849 xref: RHEA:30639 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102922 name: phenylpropanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8857 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102923 name: 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8859 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102924 name: gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-886 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102925 name: solanine UDP-galactose galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8875 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102926 name: solanidine glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8882 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102927 name: beta-chaconine rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8883 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102928 name: beta-solanine rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8884 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102929 name: lachrymatory factor synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide" [EC:5.3.-.-, GOC:pz] xref: MetaCyc:RXN-8911 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0102930 name: 4-hydroxybenzoate geranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid" [EC:2.5.1.93, GOC:pz] xref: EC:2.5.1.93 xref: MetaCyc:RXN-8920 xref: RHEA:27854 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102931 name: (Z,E)-alpha- farnesene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid" [EC:4.2.3.-, GOC:pz] xref: MetaCyc:RXN-8931 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0102932 name: pterocarpan reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-8936 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102933 name: GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate" [EC:2.6.1.102, GOC:pz] xref: EC:2.6.1.102 xref: MetaCyc:RXN-8953 xref: RHEA:36779 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0102934 name: costunolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP" [EC:1.14.14.150, GOC:pz] xref: EC:1.14.14.150 xref: MetaCyc:RXN-8971 xref: RHEA:28230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102935 name: gypsogenin-UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9012 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102936 name: gypsogenate-UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9013 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102937 name: 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9014 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102938 name: orcinol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine" [EC:2.1.1.6, GOC:pz] xref: EC:2.1.1.6 xref: MetaCyc:RXN-9017 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102939 name: 3-methoxy-5-hydroxytoluene O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9018 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102940 name: phloroglucinol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9020 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102941 name: 3,5-dihydroxyanisole O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9021 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102942 name: 3,5-dimethoxyphenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9022 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102943 name: trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate" [EC:5.3.3.17, GOC:pz] xref: EC:5.3.3.17 xref: MetaCyc:RXN-9031 xref: RHEA:28182 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0102944 name: medicagenate UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9035 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102945 name: soyasapogenol B UDP-glucosyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9037 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102946 name: soyasapogenol E UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9038 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102947 name: (+)-delta-cadinene-8-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9045 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102948 name: luteolin C-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9081 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102949 name: 1,2-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2''-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9082 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102950 name: indole-3-acetyl-valine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-9083 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102951 name: indole-3-acetyl-phenylalanine synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid" [EC:6.3.-.-, GOC:pz] xref: MetaCyc:RXN-9084 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0102952 name: UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-91 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102953 name: hypoglycin A gamma-glutamyl transpeptidase activity namespace: molecular_function def: "Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B" [EC:2.3.2.2, GOC:pz] xref: EC:2.3.2.2 xref: MetaCyc:RXN-9157 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0102954 name: dalcochinase activity namespace: molecular_function def: "Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose" [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-9162 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0102955 name: S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+" [EC:2.1.1.163, GOC:pz] xref: EC:2.1.1.163 xref: MetaCyc:RXN-9191 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102956 name: UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-92 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102960 name: momilactone-A synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H" [EC:1.1.1.295, GOC:pz] xref: EC:1.1.1.295 xref: MetaCyc:RXN-9290 xref: RHEA:25367 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102961 name: 4,4'-diapophytofluene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2" [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-9304 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102962 name: 4,4'-diapo-zeta-carotene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2" [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-9305 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102963 name: (S)-corytuberine synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O" [EC:1.14.21.-, GOC:pz] xref: MetaCyc:RXN-9314 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] id: GO:0102964 name: S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9315 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102965 name: alcohol-forming fatty acyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol" [EC:1.2.1.84, GOC:pz] xref: EC:1.2.1.84 xref: MetaCyc:RXN-9344 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102966 name: arachidoyl-CoA:1-dodecanol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A" [EC:2.3.1.75, GOC:pz] xref: EC:2.3.1.75 xref: MetaCyc:RXN-9356 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102967 name: 10-hydroxygeraniol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9367 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102968 name: 10-hydroxygeranial oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9369 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102969 name: 10-oxogeraniol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9370 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102970 name: 7-deoxyloganetic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP" [EC:2.4.1.323, GOC:pz] xref: EC:2.4.1.323 xref: MetaCyc:RXN-9372 xref: RHEA:39895 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102971 name: phosphinothricin N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate" [EC:2.3.1.183, GOC:pz] xref: EC:2.3.1.183 xref: MetaCyc:RXN-9382 xref: RHEA:12597 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102972 name: gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) namespace: molecular_function def: "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-947 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0102973 name: norsolorinate anthrone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]." [EC:2.3.1.221, GOC:pz] synonym: "norsolorinic acid synthase" EXACT [] xref: EC:2.3.1.221 xref: MetaCyc:RXN-9479 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102974 name: hydroxyversicolorone reductase activity namespace: molecular_function def: "Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH" [EC:1.1.1.353, GOC:pz] xref: EC:1.1.1.353 xref: MetaCyc:RXN-9489 xref: RHEA:35691 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102975 name: versiconal hemiacetal acetate reductase activity namespace: molecular_function def: "Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH" [EC:1.1.1.353, GOC:pz] xref: EC:1.1.1.353 xref: MetaCyc:RXN-9490 xref: RHEA:35695 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102976 name: versiconal reductase activity namespace: molecular_function def: "Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+" [EC:1.1.1.353, GOC:pz] xref: EC:1.1.1.353 xref: MetaCyc:RXN-9491 xref: RHEA:35699 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102977 name: nitrilotriacetate monooxygenase activity (FMN-dependent) namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN" [EC:1.14.14.10, GOC:pz] xref: EC:1.14.14.10 xref: MetaCyc:RXN-9508 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102978 name: furaneol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+" [EC:1.3.1.105, GOC:pz] xref: EC:1.3.1.105 xref: MetaCyc:RXN-9563 xref: RHEA:39111 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102979 name: homofuraneol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-9564 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102980 name: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-9565 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102981 name: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-9567 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102982 name: UDP-3-dehydro-alpha-D-glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9578 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0102983 name: xylogalacturonan beta-1,3-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan" [EC:2.4.2.41, GOC:pz] xref: EC:2.4.2.41 xref: MetaCyc:RXN-9589 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0102984 name: sulfoacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+" [EC:1.2.1.73, GOC:pz] xref: EC:1.2.1.73 xref: MetaCyc:RXN-9592 xref: RHEA:25637 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0102985 name: Delta12-fatty-acid desaturase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.6, GOC:pz] xref: EC:1.14.19.6 xref: MetaCyc:RXN-9601 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102986 name: trehalose synthase activity namespace: molecular_function def: "Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate" [EC:2.4.1.245, GOC:pz] xref: EC:2.4.1.245 xref: MetaCyc:RXN-9603 xref: RHEA:47416 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102987 name: palmitoleic acid delta 12 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9616 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102988 name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9617 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102989 name: 5-pentadecatrienylresorcinol synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide" [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-9618 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0102990 name: 5-n-alk(en)ylresorcinol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9619 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102991 name: myristoyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A" [EC:3.1.2.2, GOC:pz] xref: EC:3.1.2.2 xref: MetaCyc:RXN-9626 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0102992 name: 2-methylbutyronitrile hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9642 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102993 name: linolenate Delta15 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor" [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9667 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0102995 name: angelicin synthase activity namespace: molecular_function def: "Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O" [EC:1.14.14.148, GOC:pz] xref: EC:1.14.14.148 xref: MetaCyc:RXN-9689 xref: RHEA:27481 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102996 name: beta,beta digalactosyldiacylglycerol galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol" [EC:2.4.1.184, GOC:pz] xref: EC:2.4.1.184 xref: MetaCyc:RXN-9721 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0102997 name: progesterone 5beta- reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP" [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-9726 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0102998 name: 4-sulfomuconolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+" [EC:3.1.1.92, GOC:pz] xref: EC:3.1.1.92 xref: MetaCyc:RXN-9733 xref: RHEA:33711 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0102999 name: UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9743 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103000 name: UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-9748 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103001 name: dimethylsulfoxide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9767 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103002 name: 16-hydroxypalmitate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9802 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103003 name: oleate peroxygenase activity namespace: molecular_function def: "Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol" [EC:1.11.-.-, GOC:pz] xref: MetaCyc:RXN-9804 is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0103004 name: 9,10-epoxystearate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9805 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103005 name: 9,10-epoxystearate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate" [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-9806 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0103006 name: 9,10-dihydroxystearate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9807 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103007 name: indole-3-acetate carboxyl methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine" [EC:2.1.1.278, GOC:pz] xref: EC:2.1.1.278 xref: MetaCyc:RXN-9825 xref: RHEA:36131 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0103008 name: 4-chloro-2-methylphenoxyacetate oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-9864 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103009 name: 3-chlorotoluene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9908 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103010 name: gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) namespace: molecular_function def: "Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-991 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103011 name: mannosylfructose-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP" [EC:2.4.1.246, GOC:pz] xref: EC:2.4.1.246 xref: MetaCyc:RXN-9935 xref: RHEA:26039 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103012 name: ferredoxin-thioredoxin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin" [EC:1.8.7.2, GOC:pz] xref: EC:1.8.7.2 xref: MetaCyc:RXN-9944 is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor [Term] id: GO:0103014 name: beta-keto ester reductase activity namespace: molecular_function def: "Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-1941 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103015 name: 4-amino-4-deoxy-L-arabinose transferase activity namespace: molecular_function def: "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate" [EC:2.4.2.43, GOC:pz] xref: EC:2.4.2.43 xref: MetaCyc:RXN0-2001 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0103016 name: tRNA-specific 2-thiouridylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine" [GOC:pz, PMID:12949933] xref: MetaCyc:RXN0-2023 is_a: GO:0016874 ! ligase activity [Term] id: GO:0103020 name: 1-deoxy-D-xylulose kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP" [GOC:pz, PMID:11168365, PMID:16920870] xref: MetaCyc:RXN0-382 xref: RHEA:27990 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0103023 name: ITPase activity namespace: molecular_function def: "Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate" [EC:3.6.1.-, GOC:pz] xref: MetaCyc:RXN0-5073 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0103024 name: XTPase activity namespace: molecular_function def: "Catalysis of the reaction: XTP + H2O <=> H+ + XDP + monophosphate." [EC:3.6.1.-, GOC:pg, GOC:pz, PMID:16216582, PMID:22531138] comment: While XTP is not produced by cells, deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP, XTP, and dXTP. XTPase contributes to the removal of these abnormal bases from the cellular pool of nucleotide triphosphates. xref: MetaCyc:RXN0-5074 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0103025 name: alpha-amylase activity (releasing maltohexaose) namespace: molecular_function def: "Catalysis of the reaction: n H2O + a 1,4-alpha-D-glucan = alpha-maltohexaose + a 1,4-alpha-D-glucan" [EC:3.2.1.1, GOC:pz] xref: EC:3.2.1.1 xref: MetaCyc:RXN0-5181 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0103026 name: fructose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN0-5186 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0103027 name: FMN phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate" [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN0-5187 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0103028 name: murein hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide" [EC:4.2.2.-, GOC:pz] xref: MetaCyc:RXN0-5190 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0103030 name: ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5213 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103031 name: L-Ala-D/L-Glu epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate" [EC:5.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5228 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0103032 name: tartronate semialdehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5289 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103033 name: beta-galactosidase activity (lactose isomerization) namespace: molecular_function def: "Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose" [EC:5.4.1.-, GOC:pz] xref: MetaCyc:RXN0-5363 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0103035 name: NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP" [EC:1.6.5.-, GOC:pz] xref: MetaCyc:RXN0-5387 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0103036 name: NADH:menaquinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol" [GOC:pz] xref: MetaCyc:RXN0-5388 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0103037 name: L-glyceraldehyde 3-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5410 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103039 name: protein methylthiotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor" [EC:2.8.4.4, GOC:pz] xref: EC:2.8.4.4 xref: MetaCyc:RXN0-6366 is_a: GO:0035596 ! methylthiotransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0103040 name: aldose sugar dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor" [EC:1.1.5.-, GOC:pz] xref: MetaCyc:RXN0-6371 is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0103041 name: thiosulfate-thioredoxin sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin" [EC:2.8.1.-, GOC:pz] xref: MetaCyc:RXN0-6385 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0103042 name: 4-hydroxy-L-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine" [EC:4.1.2.-, GOC:pz] xref: MetaCyc:RXN0-6563 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0103043 name: 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate." [EC:3.1.4.55, GOC:pz] xref: EC:3.1.4.55 xref: MetaCyc:RXN0-6710 xref: RHEA:34795 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0103044 name: ribosomal protein S6 glutamate-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate" [EC:6.3.2.-, GOC:pz] xref: MetaCyc:RXN0-6726 is_a: GO:0018169 ! ribosomal S6-glutamic acid ligase activity [Term] id: GO:0103045 name: methione N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+" [EC:2.3.1.1, GOC:pz] xref: EC:2.3.1.1 xref: MetaCyc:RXN0-6948 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0103046 name: alanylglutamate dipeptidase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate" [EC:3.4.13.18, GOC:pz] xref: EC:3.4.13.18 xref: MetaCyc:RXN0-6981 is_a: GO:0016805 ! dipeptidase activity [Term] id: GO:0103047 name: methyl beta-D-glucoside 6-phosphate glucohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol" [EC:3.2.1.86, GOC:pz] xref: EC:3.2.1.86 xref: MetaCyc:RXN0-6994 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0103048 name: tRNA m2A37 methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA" [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN0-7007 is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0103050 name: isobutyraldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: isobutanol + NADP <=> isobutyraldehyde + NADPH + H+" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-7119 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103051 name: N1-methyladenine demethylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-methyladenine + O2 + 2-oxoglutarate <=> adenine + carbon dioxide + formaldehyde + succinate" [EC:1.14.11.33, GOC:pz] xref: MetaCyc:RXN0-984 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103052 name: N3-methylcytosine demethylase activity namespace: molecular_function def: "Catalysis of the reaction: N3-methylcytosine + O2 + 2-oxoglutarate <=> H+ + cytosine + carbon dioxide + formaldehyde + succinate" [EC:1.14.11.33, GOC:pz] xref: MetaCyc:RXN0-985 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103053 name: 1-ethyladenine demethylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-ethyladenine + O2 + 2-oxoglutarate(2-) <=> adenine + carbon dioxide + acetaldehyde + succinate" [EC:1.14.11.33, GOC:pz] xref: EC:1.14.11.33 xref: MetaCyc:RXN0-986 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103054 name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) namespace: molecular_function def: "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-162 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103055 name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-163 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103056 name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-167 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103057 name: gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate" [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-169 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0103058 name: kaempferol 3-glucoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN1F-443 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103059 name: UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN1F-474 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103060 name: kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN1F-475 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103061 name: trans-methoxy-C60-meroacyl-AMP ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN1G-4141 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0103062 name: cis-keto-C60-meroacyl-AMP ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN1G-4142 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0103063 name: trans-keto-C61-meroacyl-AMP ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]" [EC:6.2.1.-, GOC:pz] xref: MetaCyc:RXN1G-4143 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0103064 name: inositol phosphorylceramide mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + an inositol-phospho-alpha hydroxyphytoceramide = H+ + GDP + a mannosyl-inositol-phospho-alpha hydroxyphytoceramide" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN3O-663 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103066 name: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H" [EC:1.1.1.170, GOC:pz] xref: EC:1.1.1.170 xref: MetaCyc:RXN66-18 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103067 name: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H" [EC:1.1.1.170, GOC:pz] xref: EC:1.1.1.170 xref: MetaCyc:RXN66-23 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103068 name: leukotriene C4 gamma-glutamyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid" [EC:2.3.2.2, GOC:pz, PMID:1676842, PMID:9139674] xref: EC:2.3.2.2 xref: MetaCyc:RXN66-336 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0103069 name: 17-hydroxyprogesterone 21-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 17alpha-hydroxyprogesterone + NADPH + H+ + O2 <=> NADP + H2O + 11-deoxycortisol" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN66-356 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103071 name: 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA <=> formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde" [EC:4.1.-.-, GOC:pz] xref: MetaCyc:RXN66-471 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0103072 name: straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde" [EC:4.1.-.-, GOC:pz] xref: MetaCyc:RXN66-475 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0103073 name: anandamide amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+)" [EC:3.5.1.99, GOC:pz] xref: EC:3.5.1.99 xref: MetaCyc:RXN6666-2 xref: RHEA:26136 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0103074 name: glucose-6-phosphate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate" [EC:1.1.1.361, GOC:pz] xref: EC:1.1.1.361 xref: MetaCyc:RXN8J2-136 xref: RHEA:37547 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103075 name: indole-3-pyruvate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O" [EC:1.14.13.168, GOC:pz] xref: EC:1.14.13.168 xref: MetaCyc:RXNDQC-2 xref: RHEA:34331 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103077 name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4161 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103078 name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4162 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103079 name: 2-(3'-methylthio)propylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A" [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4163 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0103080 name: methylthiopropylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate" [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4164 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0103081 name: methylthiopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3'-methylthio)propylmalate <=> H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXNQT-4165 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103082 name: 2-(4'-methylthio)butylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A" [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4166 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0103083 name: methylthiobutylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate" [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4167 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0103084 name: methylthiobutylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(4'-methylthio)butylmalate <=> H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXNQT-4168 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103085 name: 2-(5'-methylthio)pentylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A" [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4169 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0103086 name: methylthiopentylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate" [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4170 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0103087 name: methylthiopentylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(5'-methylthio)pentylmalate <=> H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXNQT-4171 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103088 name: 2-(6'-methylthio)hexylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A" [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4172 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0103089 name: methylthiohexylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate" [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4173 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0103090 name: methylthiohexylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(6'-methylthio)hexylmalate <=> H+ + 2-oxo-9-methylthiononanoate + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXNQT-4174 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103091 name: 2-(7'-methylthio)heptylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A" [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4175 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0103092 name: methylthioalkylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate" [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4176 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0103093 name: methylthioalkylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(7'-methylthio)heptylmalate <=> H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide" [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXNQT-4178 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0103096 name: CYP79F1 dihomomethionine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXNQT-4309 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103097 name: CYP79F1 trihomomethionine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXNQT-4310 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103098 name: CYP79F1 tetrahomomethionine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime" [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXNQT-4311 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0103099 name: UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXNQT-4324 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103100 name: UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXNQT-4325 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103101 name: UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXNQT-4326 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103102 name: UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXNQT-4327 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103103 name: UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+" [EC:2.4.1.195, GOC:pz] xref: EC:2.4.1.195 xref: MetaCyc:RXNQT-4328 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103104 name: 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate" [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXNQT-4331 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0103105 name: 2-oxo-6-methylthiohexanoate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate" [EC:2.6.1.-, GOC:pz] xref: MetaCyc:RXNQT-4345 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0103106 name: brassinolide 23-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4397 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103107 name: castasterone 23-O-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+" [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4398 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0103111 name: D-glucosamine PTS permease activity namespace: molecular_function def: "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine" [EC:2.7.1.69, GOC:pz] xref: EC:2.7.1.69 xref: MetaCyc:TRANS-RXN-167A is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0103113 name: glucosyl-oleandomycin-exporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: glucosyl-oleandomycin + ATP + H2O <=> glucosyl-oleandomycin + ADP + hydrogenphosphate + H+" [EC:3.6.3.-, GOC:pz] xref: MetaCyc:TRANS-RXN-220 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0103116 name: ATPase-coupled alpha-D-galactofuranose transporter activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+" [GOC:pz] synonym: "alpha-D-galactofuranose transporter activity" EXACT [] synonym: "ATP-dependent alpha-D-galactofuranose transporter activity" EXACT [] xref: MetaCyc:TRANS-RXN0-491 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] id: GO:0103117 name: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate" [EC:3.5.1.108, GOC:pz] xref: EC:3.5.1.108 xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0103118 name: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]" [EC:2.3.1.191, GOC:pz] xref: EC:2.3.1.191 xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN xref: RHEA:17817 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0104004 name: cellular response to environmental stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] is_a: GO:0051716 ! cellular response to stimulus created_by: dos creation_date: 2017-02-17T16:02:42Z [Term] id: GO:0104005 name: obsolete hijacked molecular function namespace: molecular_function def: "OBSOLETE. A function that was not selected for in the evolution of an organism, but arises from co-option by another organism, e.g. a human protein used as a virus receptor." [GOC:pdt] comment: This term was obsoleted because it was an unnecessary grouping class, see https://github.com/geneontology/go-ontology/issues/16741 is_obsolete: true created_by: dos creation_date: 2017-08-04T02:12:09Z [Term] id: GO:0106001 name: intestinal hexose absorption namespace: biological_process def: "Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine." [GOC:hjd] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0106002 name: mCRD-mediated mRNA stability complex namespace: cellular_component def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] comment: This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA. synonym: "major coding region determinant of instability-mediated mRNA stability complex" EXACT [] synonym: "major coding region instability determinant-mediated mRNA stability complex" EXACT [] synonym: "major coding region instability determinant-poly(A)-bridging complex" EXACT [] synonym: "major coding-region determinant of instability - poly(A) tail-bridging complex" EXACT [] synonym: "mCRD-poly(A)-bridging complex" EXACT [] xref: IntAct:EBI-13948957 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0106003 name: amyloid-beta complex namespace: cellular_component def: "Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease." [GOC:bhm, PMID:18568035] comment: An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay). synonym: "Abeta complex" EXACT [] synonym: "Abeta-derived diffusible ligand complex" NARROW [] synonym: "ADDL complex" NARROW [] synonym: "amyloid beta complex" EXACT [] synonym: "amyloid beta dimer" NARROW [] synonym: "amyloid beta heterodimer" NARROW [] synonym: "amyloid beta heterooligomer" NARROW [] synonym: "amyloid beta heterotrimer" NARROW [] synonym: "amyloid beta homodimer" NARROW [] synonym: "amyloid beta homooligomer" NARROW [] synonym: "amyloid beta homotrimer" NARROW [] synonym: "amyloid beta oligomer" NARROW [] synonym: "amyloid beta trimer" NARROW [] synonym: "amyloid-beta protein 40 complex" NARROW [] synonym: "amyloid-beta protein 40/42 complex" NARROW [] synonym: "amyloid-beta protein 42 complex" NARROW [] synonym: "beta amyloid complex" EXACT [] synonym: "beta-amyloid complex" EXACT [] synonym: "betaA complex" EXACT [] synonym: "heterodimer of amyloid beta protein" NARROW [] synonym: "heterooligomer of amyloid beta protein" NARROW [] synonym: "heterotrimer of amyloid beta protein" NARROW [] synonym: "homodimer of amyloid beta protein" NARROW [] synonym: "homooligomer of amyloid beta protein" NARROW [] synonym: "homotrimer of amyloid beta protein" NARROW [] is_a: GO:0032991 ! protein-containing complex created_by: hjd creation_date: 2017-03-15T19:19:29Z [Term] id: GO:0106004 name: tRNA (guanine-N7)-methylation namespace: biological_process def: "The process whereby a guanine in a tRNA is methylated at the N7 position of guanine." [GOC:hjd, PMID:17382321] is_a: GO:0030488 ! tRNA methylation is_a: GO:0036265 ! RNA (guanine-N7)-methylation created_by: hjd creation_date: 2017-04-07T18:17:38Z [Term] id: GO:0106005 name: RNA 5'-cap (guanine-N7)-methylation namespace: biological_process def: "The process whereby a guanine in 5-cap is methylated at the N7 position of guanine." [GOC:hjd] is_a: GO:0036265 ! RNA (guanine-N7)-methylation relationship: part_of GO:0009452 ! 7-methylguanosine RNA capping created_by: hjd creation_date: 2017-04-07T19:19:57Z [Term] id: GO:0106006 name: microtubule cortical anchor activity namespace: molecular_function def: "The binding activity that attaches a microtubule to the cell cortex." [GOC:hjd, PMID:25736293] is_a: GO:0008093 ! cytoskeletal adaptor activity created_by: hjd creation_date: 2017-04-14T15:11:13Z [Term] id: GO:0106007 name: microtubule anchoring at cell cortex of cell tip namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex." [GOC:mah, PMID:25736293] is_a: GO:0034453 ! microtubule anchoring created_by: hjd creation_date: 2017-04-19T15:12:45Z [Term] id: GO:0106008 name: 2-oxoglutaramate amidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3)." [EC:3.5.1.111, PMID:21288482] xref: EC:3.5.1.111 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: hjd creation_date: 2017-04-25T14:10:02Z [Term] id: GO:0106009 name: (4S)-4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418] xref: EC:4.1.3.42 is_a: GO:0016833 ! oxo-acid-lyase activity created_by: hjd creation_date: 2017-04-25T14:14:58Z [Term] id: GO:0106011 name: regulation of protein localization to medial cortex namespace: biological_process def: "Any process that regulates the localization of a protein to the medial cortex." [GOC:hjd] is_a: GO:1901900 ! regulation of protein localization to cell division site is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071574 ! protein localization to medial cortex relationship: regulates GO:0071574 ! protein localization to medial cortex created_by: hjd creation_date: 2017-04-27T17:29:56Z [Term] id: GO:0106012 name: positive regulation of protein localization to medial cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex." [GOC:hjd, PMID:19474789] is_a: GO:0106011 ! regulation of protein localization to medial cortex is_a: GO:1904778 ! positive regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071574 ! protein localization to medial cortex relationship: positively_regulates GO:0071574 ! protein localization to medial cortex created_by: hjd creation_date: 2017-04-27T17:36:17Z [Term] id: GO:0106013 name: negative regulation of protein localization to cell cortex of cell tip namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip." [GOC:vw, PMID:19474792] is_a: GO:1990895 ! regulation of protein localization to cell cortex of cell tip created_by: hjd creation_date: 2017-04-28T13:45:38Z [Term] id: GO:0106014 name: regulation of inflammatory response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090594 ! inflammatory response to wounding relationship: regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:03:14Z [Term] id: GO:0106015 name: negative regulation of inflammatory response to wounding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903035 ! negative regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0090594 ! inflammatory response to wounding relationship: negatively_regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:09:46Z [Term] id: GO:0106016 name: positive regulation of inflammatory response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1903036 ! positive regulation of response to wounding intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0090594 ! inflammatory response to wounding relationship: positively_regulates GO:0090594 ! inflammatory response to wounding created_by: hjd creation_date: 2017-04-28T20:16:31Z [Term] id: GO:0106017 name: phosphatidylinositol-3,4-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity created_by: hjd creation_date: 2017-05-10T14:08:06Z [Term] id: GO:0106018 name: phosphatidylinositol-3,5-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity created_by: hjd creation_date: 2017-05-10T14:19:13Z [Term] id: GO:0106019 name: phosphatidylinositol-4,5-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity created_by: hjd creation_date: 2017-05-10T14:22:12Z [Term] id: GO:0106020 name: regulation of vesicle docking namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle docking." [PMID:22810233] synonym: "regulation of vesicle to membrane docking" EXACT [] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048278 ! vesicle docking relationship: regulates GO:0048278 ! vesicle docking created_by: hjd creation_date: 2017-05-16T13:58:54Z [Term] id: GO:0106021 name: negative regulation of vesicle docking namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking." [PMID:22810233] synonym: "negative regulation of vesicle to membrane docking" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport is_a: GO:0106020 ! regulation of vesicle docking intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048278 ! vesicle docking relationship: negatively_regulates GO:0048278 ! vesicle docking created_by: hjd creation_date: 2017-05-16T14:05:29Z [Term] id: GO:0106022 name: positive regulation of vesicle docking namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle docking." [PMID:22810233] synonym: "positive regulation of vesicle to membrane docking" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport is_a: GO:0106020 ! regulation of vesicle docking intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048278 ! vesicle docking relationship: positively_regulates GO:0048278 ! vesicle docking created_by: hjd creation_date: 2017-05-16T14:12:32Z [Term] id: GO:0106023 name: regulation of pupariation namespace: biological_process def: "Any process that modulates the onset of pupariation." [PMID:26510564] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035073 ! pupariation relationship: regulates GO:0035073 ! pupariation created_by: hjd creation_date: 2017-05-24T19:31:39Z [Term] id: GO:0106024 name: negative regulation of pupariation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of onset of pupariation." [PMID:26510564] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0106023 ! regulation of pupariation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035073 ! pupariation relationship: negatively_regulates GO:0035073 ! pupariation created_by: hjd creation_date: 2017-05-24T19:35:29Z [Term] id: GO:0106025 name: positive regulation of pupariation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of onset of pupariation." [GOC:hjd] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0106023 ! regulation of pupariation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035073 ! pupariation relationship: positively_regulates GO:0035073 ! pupariation created_by: hjd creation_date: 2017-05-24T19:37:50Z [Term] id: GO:0106026 name: Gly-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)." [PMID:28362257] is_a: GO:0002161 ! aminoacyl-tRNA editing activity created_by: hjd creation_date: 2017-06-16T17:13:33Z [Term] id: GO:0106027 name: neuron projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: hjd creation_date: 2017-06-23T18:30:18Z [Term] id: GO:0106028 name: neuron projection retraction namespace: biological_process def: "The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:aruk, GOC:bc, PMID:11585923.] synonym: "neuron projection disassembly" EXACT [] is_a: GO:0106027 ! neuron projection organization created_by: hjd creation_date: 2017-06-23T18:32:42Z [Term] id: GO:0106029 name: tRNA pseudouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:11095668] synonym: "Mitochondrial tRNA pseudouridine(27/28) synthase" NARROW [EC:5.4.99.44] synonym: "transfer ribonucleate pseudouridine synthetase activity" EXACT [] synonym: "transfer RNA pseudouridine synthetase activity" EXACT [] synonym: "tRNA pseudouridine(13) synthase" NARROW [EC:5.4.99.27] synonym: "tRNA pseudouridine(31) synthase" NARROW [EC:5.4.99.42] synonym: "tRNA pseudouridine(32) synthase" NARROW [EC:5.4.99.28] synonym: "tRNA pseudouridine(38-40) synthase" NARROW [EC:5.4.99.12] synonym: "tRNA pseudouridine(38/39) synthase" NARROW [EC:5.4.99.45] synonym: "tRNA pseudouridine(55) synthase" NARROW [EC:5.4.99.25] synonym: "tRNA pseudouridine(65) synthase" NARROW [EC:5.4.99.26] synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] synonym: "tRNA-pseudouridine synthase activity" EXACT [] synonym: "tRNA-pseudouridine synthase I activity" NARROW [EC:5.4.99.12] synonym: "tRNA-uridine isomerase activity" EXACT [] synonym: "tRNA-uridine uracilmutase activity" EXACT [] xref: EC:5.4.99.12 xref: EC:5.4.99.25 xref: EC:5.4.99.26 xref: EC:5.4.99.27 xref: EC:5.4.99.28 xref: EC:5.4.99.42 xref: EC:5.4.99.44 xref: EC:5.4.99.45 xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN is_a: GO:0009982 ! pseudouridine synthase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: hjd creation_date: 2017-06-26T17:37:30Z [Term] id: GO:0106030 name: neuron projection fasciculation namespace: biological_process def: "The collection of neuronal projections into a bundle of rods, known as a fascicle." [GOC:aruk, GOC:bc., PMID:12761826] is_a: GO:0031175 ! neuron projection development created_by: hjd creation_date: 2017-06-26T19:43:23Z [Term] id: GO:0106032 name: snRNA pseudouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181] is_a: GO:0009982 ! pseudouridine synthase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: hjd creation_date: 2017-06-28T17:44:20Z [Term] id: GO:0106033 name: spine synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine." [PMID:15028757] synonym: "dendritic spine synapse" EXACT [] is_a: GO:0032279 ! asymmetric synapse created_by: hjd creation_date: 2017-07-05T19:20:48Z [Term] id: GO:0106034 name: protein maturation by [2Fe-2S] cluster transfer namespace: biological_process def: "The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440] is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer created_by: hjd creation_date: 2017-07-07T17:24:59Z [Term] id: GO:0106035 name: protein maturation by [4Fe-4S] cluster transfer namespace: biological_process def: "The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440] is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer created_by: hjd creation_date: 2017-07-07T17:26:10Z [Term] id: GO:0106036 name: assembly of apicomedial cortex actomyosin namespace: biological_process def: "A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin." [PMID:28263180] is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0031032 ! actomyosin structure organization created_by: hjd creation_date: 2017-07-12T16:57:06Z [Term] id: GO:0106037 name: apicomedial cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell." [PMID:23831726, PMID:28263180] synonym: "medioapical cortex" EXACT [] is_a: GO:0045179 ! apical cortex relationship: part_of GO:0045179 ! apical cortex created_by: hjd creation_date: 2017-07-12T16:59:52Z [Term] id: GO:0106038 name: obsolete vesicle assembly namespace: biological_process def: "OBSOLETE. A process carried out at the cellular level, which results in the arrangement of constituent parts of a vesicle. Vesicle assembly begins with membrane bending (GO:0097753) and ends with fusion of the vesicle after vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166] comment: This term was made obsolete because it is an exact synonym of 'membrane budding'. synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle formation" EXACT [] is_obsolete: true created_by: hjd creation_date: 2017-07-17T13:52:28Z [Term] id: GO:0106039 name: obsolete vesicle fusion involved in vesicle assembly namespace: biological_process def: "OBSOLETE. A process carried out at the cellular level, which is the final step in vesicle assembly. Vesicle fusion occurs when a newly assembled vesicle closes up, following vesicle vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166] comment: This term was made obsolete becausethat 'fusion' should only be used for two membranes getting joined together, whereas in this case it would be one membrane 'closing/sealing up'. is_obsolete: true created_by: hjd creation_date: 2017-07-17T13:56:31Z [Term] id: GO:0106040 name: regulation of GABA-A receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004890 ! GABA-A receptor activity relationship: regulates GO:0004890 ! GABA-A receptor activity created_by: hjd creation_date: 2017-07-27T18:47:02Z [Term] id: GO:0106041 name: positive regulation of GABA-A receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] is_a: GO:0106040 ! regulation of GABA-A receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004890 ! GABA-A receptor activity relationship: positively_regulates GO:0004890 ! GABA-A receptor activity created_by: hjd creation_date: 2017-07-27T18:51:30Z [Term] id: GO:0106042 name: negative regulation of GABA-A receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] is_a: GO:0106040 ! regulation of GABA-A receptor activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004890 ! GABA-A receptor activity relationship: negatively_regulates GO:0004890 ! GABA-A receptor activity created_by: hjd creation_date: 2017-07-27T18:55:03Z [Term] id: GO:0106044 name: guanine deglycation namespace: biological_process def: "The removal of a sugar or dicarbonyl from a glycated guanine." [PMID:28596309] is_a: GO:0009117 ! nucleotide metabolic process created_by: hjd creation_date: 2017-08-01T18:15:28Z [Term] id: GO:0106045 name: guanine deglycation, methylglyoxal removal namespace: biological_process def: "The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine." [PMID:28596309] is_a: GO:0106044 ! guanine deglycation is_a: GO:0140041 ! cellular detoxification of methylglyoxal created_by: hjd creation_date: 2017-08-01T18:17:28Z [Term] id: GO:0106046 name: guanine deglycation, glyoxal removal namespace: biological_process def: "The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine." [PMID:28596309] is_a: GO:0106044 ! guanine deglycation created_by: hjd creation_date: 2017-08-01T18:19:30Z [Term] id: GO:0106047 name: polyamine deacetylation namespace: biological_process def: "The modification of acetylpolyamine by the removal of acetyl groups." [PMID:28516954] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0098732 ! macromolecule deacylation created_by: hjd creation_date: 2017-08-01T18:36:46Z [Term] id: GO:0106048 name: spermidine deacetylation namespace: biological_process def: "The modification of acetylspermadine by the removal of acetyl groups." [PMID:28516954] synonym: "N8-acetylspermidine deacetylation" EXACT [] is_a: GO:0008216 ! spermidine metabolic process is_a: GO:0106047 ! polyamine deacetylation created_by: hjd creation_date: 2017-08-01T18:39:17Z [Term] id: GO:0106049 name: regulation of cellular response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress." [PMID:10398679] is_a: GO:0047484 ! regulation of response to osmotic stress is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071470 ! cellular response to osmotic stress relationship: regulates GO:0071470 ! cellular response to osmotic stress created_by: hjd creation_date: 2017-08-04T14:53:47Z [Term] id: GO:0106050 name: tRNA 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide." [PMID:17242307] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity created_by: hjd creation_date: 2017-08-11T20:30:31Z [Term] id: GO:0106054 name: tRNA U34 thiol-transferase activity namespace: molecular_function def: "Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [PMID:12549933, PMID:16387657] synonym: "tRNA U34 2-thiouridylase" EXACT [] synonym: "tRNA-specific 2-thiouridylase" RELATED [] is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0002098 ! tRNA wobble uridine modification created_by: hjd creation_date: 2017-09-05T19:10:12Z [Term] id: GO:0106055 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase complex namespace: cellular_component def: "A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bhm, PMID:21700223] comment: An example is MNL1 (P38888) in Saccharomyces cerevisiae. PMID:19124653 (by physical interaction evidence). xref: IntAct:EBI-16411902 is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005788 ! endoplasmic reticulum lumen created_by: hjd creation_date: 2017-09-14T15:23:28Z [Term] id: GO:0106056 name: regulation of calcineurin-mediated signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] is_a: GO:0050848 ! regulation of calcium-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097720 ! calcineurin-mediated signaling relationship: regulates GO:0097720 ! calcineurin-mediated signaling created_by: hjd creation_date: 2017-09-18T16:44:05Z [Term] id: GO:0106057 name: negative regulation of calcineurin-mediated signaling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signalling." [PMID:25081204] is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:0106056 ! regulation of calcineurin-mediated signaling intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097720 ! calcineurin-mediated signaling relationship: negatively_regulates GO:0097720 ! calcineurin-mediated signaling created_by: hjd creation_date: 2017-09-18T16:50:11Z [Term] id: GO:0106058 name: positive regulation of calcineurin-mediated signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0106056 ! regulation of calcineurin-mediated signaling intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097720 ! calcineurin-mediated signaling relationship: positively_regulates GO:0097720 ! calcineurin-mediated signaling created_by: hjd creation_date: 2017-09-18T16:57:06Z [Term] id: GO:0106059 name: tRNA (cytidine56-2'-O)-methyltransferase namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA" [EC:2.1.1.206] is_a: GO:0052666 ! tRNA (cytosine-2'-O-)-methyltransferase activity created_by: hjd creation_date: 2017-10-05T19:02:22Z [Term] id: GO:0106060 name: regulation of exit from meiosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exit from mitosis." [GOC:al, PMID:11493649] is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990947 ! exit from meiosis relationship: regulates GO:1990947 ! exit from meiosis created_by: hjd creation_date: 2017-10-18T16:48:01Z [Term] id: GO:0106061 name: negative regulation of exit from meiosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649] is_a: GO:0106060 ! regulation of exit from meiosis is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990947 ! exit from meiosis relationship: negatively_regulates GO:1990947 ! exit from meiosis created_by: hjd creation_date: 2017-10-18T16:51:15Z [Term] id: GO:0106062 name: positive regulation of exit from meiosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649] is_a: GO:0106060 ! regulation of exit from meiosis is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990947 ! exit from meiosis relationship: positively_regulates GO:1990947 ! exit from meiosis created_by: hjd creation_date: 2017-10-18T16:57:01Z [Term] id: GO:0106063 name: G protein-coupled folate receptor activity namespace: molecular_function def: "Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [PMID:26906738] synonym: "G-protein coupled folate receptor activity" EXACT [] synonym: "G-protein coupled folic acid receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity created_by: hjd creation_date: 2017-10-27T17:10:07Z [Term] id: GO:0106064 name: regulation of cobalamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009235 ! cobalamin metabolic process relationship: regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2017-10-27T17:33:05Z [Term] id: GO:0106068 name: SUMO ligase complex namespace: cellular_component def: "A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex." [PMID:16847351] synonym: "SUMO transferase complex" EXACT [] synonym: "SUMO-protein ligase complex" EXACT [] synonym: "Sumoylation complex" EXACT [] is_a: GO:1990234 ! transferase complex created_by: hjd creation_date: 2017-11-22T18:46:00Z [Term] id: GO:0106069 name: synapsis initiation complex namespace: cellular_component def: "A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase." [PMID:16847351] xref: IntAct:EBI-16586568 is_a: GO:0106068 ! SUMO ligase complex relationship: part_of GO:0000794 ! condensed nuclear chromosome created_by: hjd creation_date: 2017-11-22T18:50:26Z [Term] id: GO:0106070 name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway" [GOC:hjd, PMID:19246489] synonym: "regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0043949 ! regulation of cAMP-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway relationship: regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway created_by: hjd creation_date: 2017-11-28T18:28:22Z [Term] id: GO:0106071 name: positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489] synonym: "positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0043950 ! positive regulation of cAMP-mediated signaling is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway relationship: positively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway created_by: hjd creation_date: 2017-11-28T18:38:52Z [Term] id: GO:0106072 name: negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489] synonym: "negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway relationship: negatively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway created_by: hjd creation_date: 2017-11-28T18:41:31Z [Term] id: GO:0106073 name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543] xref: EC:2.4.1.256 is_a: GO:0046527 ! glucosyltransferase activity created_by: hjd creation_date: 2017-11-28T19:16:37Z [Term] id: GO:0106074 name: aminoacyl-tRNA metabolism involved in translational fidelity namespace: biological_process def: "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation." [GOC:hjd] synonym: "aminoacyl-tRNA correction" RELATED [] synonym: "aminoacyl-tRNA editin" RELATED [] synonym: "aminoacyl-tRNA proofreading" RELATED [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0006450 ! regulation of translational fidelity created_by: hjd creation_date: 2017-11-29T17:48:39Z [Term] id: GO:0106075 name: peptide N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide." [PMID:29211711] is_a: GO:0016410 ! N-acyltransferase activity created_by: hjd creation_date: 2017-12-15T18:23:58Z [Term] id: GO:0106076 name: peptide-lysine-N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide." [PMID:29211711] is_a: GO:0106075 ! peptide N-succinyltransferase activity created_by: hjd creation_date: 2017-12-15T18:25:16Z [Term] id: GO:0106077 name: histone succinylation namespace: biological_process def: "The modification of a histone by the addition of an succinyl group." [PMID:29211711] is_a: GO:0018335 ! protein succinylation created_by: hjd creation_date: 2017-12-15T18:27:16Z [Term] id: GO:0106078 name: histone succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone." [PMID:29211711] is_a: GO:0106075 ! peptide N-succinyltransferase activity created_by: hjd creation_date: 2017-12-15T18:29:40Z [Term] id: GO:0106080 name: GATOR1 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GATOR1 complex." [PMID:28199306] is_a: GO:0044877 ! protein-containing complex binding created_by: hjd creation_date: 2017-12-22T14:49:54Z [Term] id: GO:0106081 name: maltose import across plasma membrane namespace: biological_process def: "The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464] is_a: GO:0098704 ! carbohydrate import across plasma membrane is_a: GO:1904981 ! maltose transmembrane transport created_by: hjd creation_date: 2017-12-28T18:14:16Z [Term] id: GO:0106082 name: sucrose import across plasma membrane namespace: biological_process def: "The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464] is_a: GO:0098704 ! carbohydrate import across plasma membrane is_a: GO:1904982 ! sucrose transmembrane transport created_by: hjd creation_date: 2017-12-28T18:16:29Z [Term] id: GO:0106083 name: nuclear membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the nuclear membrane." [GOC:lnp, PMID:28356353] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005635 ! nuclear envelope relationship: part_of GO:0031224 ! intrinsic component of membrane created_by: hjd creation_date: 2018-01-05T19:51:26Z [Term] id: GO:0106084 name: nuclear membrane mitotic spindle pole body tethering complex namespace: cellular_component def: "A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane." [GOC:lnp, PMID:28356353] comment: In S. cerevisae Mps2-Bpb1 is the membrane anchor sub complex and Spc29 is the spindle pole body linker molecule. synonym: "Mps2-Bbp1-Spc29 complex" RELATED [] xref: IntAct:EBI-16412392 is_a: GO:0106083 ! nuclear membrane protein complex created_by: hjd creation_date: 2018-01-05T19:55:37Z [Term] id: GO:0106088 name: regulation of cell adhesion involved in sprouting angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:1903670 ! regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis relationship: regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis created_by: hjd creation_date: 2018-01-22T18:24:12Z [Term] id: GO:0106089 name: negative regulation of cell adhesion involved in sprouting angiogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis is_a: GO:1903671 ! negative regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis relationship: negatively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis created_by: hjd creation_date: 2018-01-22T18:28:08Z [Term] id: GO:0106090 name: positive regulation of cell adhesion involved in sprouting angiogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] is_a: GO:0045785 ! positive regulation of cell adhesion is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis is_a: GO:1903672 ! positive regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis relationship: positively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis created_by: hjd creation_date: 2018-01-22T18:31:02Z [Term] id: GO:0106091 name: glial cell projection elongation namespace: biological_process def: "The process of creating an elongation or projection from a glial cell." [GOC:ha, PMID:27131624] is_a: GO:0048858 ! cell projection morphogenesis relationship: part_of GO:0021782 ! glial cell development created_by: hjd creation_date: 2018-01-26T19:40:19Z [Term] id: GO:0106092 name: glial cell projection elongation involved in axon ensheathment namespace: biological_process def: "The extension of a glial cell process or projection to wrap around an axon." [GOC:ha, PMID:27131624] is_a: GO:0008366 ! axon ensheathment is_a: GO:0106091 ! glial cell projection elongation created_by: hjd creation_date: 2018-01-26T19:43:00Z [Term] id: GO:0106093 name: EDS1 disease-resistance complex namespace: cellular_component def: "A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes." [GOC:bhm, PMID:11574472, PMID:16040633] comment: Interacts with the R genes triggering ETI and systemic resistance. synonym: "EDS1-PAD4 complex" NARROW [] synonym: "EDS1-PAD4-SAG101 complex" NARROW [] synonym: "EDS1-SAG101 complex" NARROW [] xref: IntAct:EBI-16422538 xref: IntAct:EBI-16423002 xref: IntAct:EBI-16423498 xref: IntAct:EBI-16748636 xref: IntAct:EBI-16748699 xref: IntAct:EBI-16748728 is_a: GO:0032991 ! protein-containing complex created_by: hjd creation_date: 2018-01-29T20:02:47Z [Term] id: GO:0106094 name: nuclear membrane microtubule tethering complex namespace: cellular_component def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules." [GOC:vw, PMID:19225124] is_a: GO:0106083 ! nuclear membrane protein complex created_by: hjd creation_date: 2018-02-02T18:58:35Z [Term] id: GO:0106095 name: m7G(5')pppN diphosphatase complex namespace: cellular_component def: "A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide." [GOC:lnp, PMID:22985415, PMID:26258763] synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme" EXACT [] synonym: "DCS1 decapping scavenger complex" EXACT [] synonym: "M(7)G(5')pppN pyrophosphatase enzyme" EXACT [] synonym: "m7G(5')pppN diphosphatase enzyme" EXACT [] synonym: "m7G(5')pppN pyrophosphatase enzyme" EXACT [] xref: IntAct:EBI-15484673 is_a: GO:0034518 ! RNA cap binding complex is_a: GO:1903293 ! phosphatase complex created_by: hjd creation_date: 2018-02-07T17:52:03Z [Term] id: GO:0106096 name: response to ceramide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463] is_a: GO:0033993 ! response to lipid created_by: hjd creation_date: 2018-02-12T19:48:43Z [Term] id: GO:0106097 name: cellular response to ceramide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463] is_a: GO:0071396 ! cellular response to lipid created_by: hjd creation_date: 2018-02-12T19:52:55Z [Term] id: GO:0106098 name: NAGS/NAGK complex namespace: cellular_component def: "A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate." [GOC:lnp, PMID:11553611] xref: IntAct:EBI-15101175 is_a: GO:0031248 ! protein acetyltransferase complex is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix created_by: hjd creation_date: 2018-02-15T00:22:31Z [Term] id: GO:0106099 name: 2-keto-3-deoxy-L-rhamnonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde." [EC:4.1.2.53, GOC:imk, PMID:18754683] xref: EC:4.1.2.53 is_a: GO:0016832 ! aldehyde-lyase activity created_by: hjd creation_date: 2018-02-15T16:12:17Z [Term] id: GO:0106100 name: beta-pinacene synthase activity namespace: molecular_function def: "Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene." [GOC:rjd, PMID:28696553] is_a: GO:0010333 ! terpene synthase activity created_by: hjd creation_date: 2018-02-15T16:51:59Z [Term] id: GO:0106101 name: ER-dependent peroxisome localization namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum." [GOC:pga, PMID:19479899, PMID:26408931] is_a: GO:0072662 ! protein localization to peroxisome created_by: hjd creation_date: 2018-02-15T17:54:20Z [Term] id: GO:0106103 name: COPII vesicles tethering complex namespace: cellular_component def: "A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae." [GOC:lnp, PMID:21482742, PMID:9628863] synonym: "Bug1-Grh1 complex" NARROW [] synonym: "GRASP65-GM130 complex" EXACT [] xref: IntAct:EBI-14061261 is_a: GO:0098796 ! membrane protein complex is_a: GO:0099023 ! vesicle tethering complex relationship: part_of GO:0033106 ! cis-Golgi network membrane created_by: hjd creation_date: 2018-02-15T23:36:12Z [Term] id: GO:0106104 name: regulation of glutamate receptor clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate receptor clustering." [GOC:ha, PMID:28455372] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:1903909 ! regulation of receptor clustering intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097688 ! glutamate receptor clustering relationship: regulates GO:0097688 ! glutamate receptor clustering created_by: hjd creation_date: 2018-03-06T15:54:33Z [Term] id: GO:0106105 name: Ala-tRNA(Thr) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated ala-tRNA(thr)." [PMID:29410408] synonym: "L-alanyl-tRNA(Thr) deacylase" EXACT [] is_a: GO:0002161 ! aminoacyl-tRNA editing activity created_by: hjd creation_date: 2018-03-14T22:03:29Z [Term] id: GO:0106106 name: cold-induced thermogenesis namespace: biological_process def: "The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature." [PMID:27876809] synonym: "CIT" RELATED [] is_a: GO:0001659 ! temperature homeostasis is_a: GO:1990845 ! adaptive thermogenesis created_by: hjd creation_date: 2018-03-21T20:30:52Z [Term] id: GO:0106107 name: regulation of (R)-mevalonic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process" [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process relationship: regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process created_by: hjd creation_date: 2018-03-27T14:08:59Z [Term] id: GO:0106108 name: negative regulation of (R)-mevalonic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process" [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process relationship: negatively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process created_by: hjd creation_date: 2018-03-27T14:15:55Z [Term] id: GO:0106109 name: positive regulation of (R)-mevalonic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process" [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process relationship: positively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process created_by: hjd creation_date: 2018-03-27T14:20:47Z [Term] id: GO:0106110 name: vomitoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [http://www.inchem.org/documents/jecfa/jecmono/v47je05.htm, https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056] synonym: "deoxynivalenol biosynthetic process" EXACT [] synonym: "DON biosynthetic process" EXACT [] synonym: "vomitoxin anabolism" EXACT [] synonym: "vomitoxin biosynthesis" EXACT [] synonym: "vomitoxin formation" EXACT [] synonym: "vomitoxin synthesis" EXACT [] is_a: GO:0043386 ! mycotoxin biosynthetic process created_by: hjd creation_date: 2018-04-16T19:06:06Z [Term] id: GO:0106111 name: regulation of mitotic cohesin ssDNA (lagging strand) loading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] is_a: GO:1905405 ! regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading relationship: regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading created_by: hjd creation_date: 2018-04-18T14:36:47Z [Term] id: GO:0106112 name: negative regulation of mitotic cohesin ssDNA (lagging strand) loading namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] is_a: GO:0106111 ! regulation of mitotic cohesin ssDNA (lagging strand) loading is_a: GO:1905412 ! negative regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading relationship: negatively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading created_by: hjd creation_date: 2018-04-18T14:41:50Z [Term] id: GO:0106113 name: positive regulation of mitotic cohesin ssDNA (lagging strand) loading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] is_a: GO:0106111 ! regulation of mitotic cohesin ssDNA (lagging strand) loading is_a: GO:1905406 ! positive regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading relationship: positively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading created_by: hjd creation_date: 2018-04-18T14:46:03Z [Term] id: GO:0106114 name: regulation of mitotic cohesin dsDNA (leading strand) loading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] is_a: GO:1905405 ! regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading relationship: regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading created_by: hjd creation_date: 2018-04-18T14:48:13Z [Term] id: GO:0106115 name: negative regulation of mitotic cohesin dsDNA (leading strand) loading namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] is_a: GO:0106114 ! regulation of mitotic cohesin dsDNA (leading strand) loading is_a: GO:1905412 ! negative regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading relationship: negatively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading created_by: hjd creation_date: 2018-04-18T14:50:12Z [Term] id: GO:0106116 name: positive regulation of mitotic cohesin dsDNA (leading strand) loading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] is_a: GO:0106114 ! regulation of mitotic cohesin dsDNA (leading strand) loading is_a: GO:1905406 ! positive regulation of mitotic cohesin loading intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading relationship: positively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading created_by: hjd creation_date: 2018-04-18T14:52:21Z [Term] id: GO:0106117 name: acidocalcisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GO:0020022, PMID:25964650, PMID:26523947] synonym: "acidocalcisome biogenesis" EXACT [] synonym: "acidocalcisome organisation" EXACT [] synonym: "acidocalcisome organization and biogenesis" EXACT [] synonym: "metachromatic granule organization" EXACT [] synonym: "polyphosphate vacuole organization" RELATED [] synonym: "volutin granule organization" EXACT [] is_a: GO:0006996 ! organelle organization created_by: hjd creation_date: 2018-04-19T17:18:01Z [Term] id: GO:0106118 name: regulation of sterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016126 ! sterol biosynthetic process relationship: regulates GO:0016126 ! sterol biosynthetic process created_by: hjd creation_date: 2018-04-19T17:41:06Z [Term] id: GO:0106119 name: negative regulation of sterol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0106118 ! regulation of sterol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016126 ! sterol biosynthetic process relationship: negatively_regulates GO:0016126 ! sterol biosynthetic process created_by: hjd creation_date: 2018-04-19T17:44:46Z [Term] id: GO:0106120 name: positive regulation of sterol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0106118 ! regulation of sterol biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016126 ! sterol biosynthetic process relationship: positively_regulates GO:0016126 ! sterol biosynthetic process created_by: hjd creation_date: 2018-04-19T17:48:21Z [Term] id: GO:0106121 name: positive regulation of cobalamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009235 ! cobalamin metabolic process relationship: positively_regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2018-05-01T18:07:12Z [Term] id: GO:0106122 name: negative regulation of cobalamin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009235 ! cobalamin metabolic process relationship: negatively_regulates GO:0009235 ! cobalamin metabolic process created_by: hjd creation_date: 2018-05-01T18:12:48Z [Term] id: GO:0106123 name: reservosome namespace: cellular_component def: "A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes." [GOC:ach, PMID:12204365, PMID:15521631, PMID:1845219, PMID:19288526, PMID:21818313, PMID:22425988] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole created_by: hjd creation_date: 2018-05-03T17:48:59Z [Term] id: GO:0106124 name: reservosome lumen namespace: cellular_component def: "The volume enclosed by the membranes of a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0106123 ! reservosome created_by: hjd creation_date: 2018-05-03T17:54:46Z [Term] id: GO:0106125 name: reservosome matrix namespace: cellular_component def: "A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0106123 ! reservosome created_by: hjd creation_date: 2018-05-03T18:00:03Z [Term] id: GO:0106126 name: reservosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0106123 ! reservosome created_by: hjd creation_date: 2018-05-03T18:01:26Z [Term] id: GO:0106128 name: negative regulation of store-operated calcium entry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642] is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:2001256 ! regulation of store-operated calcium entry intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002115 ! store-operated calcium entry relationship: negatively_regulates GO:0002115 ! store-operated calcium entry created_by: hjd creation_date: 2018-05-10T18:59:12Z [Term] id: GO:0106129 name: positive regulation of store-operated calcium entry namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642] is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:2001256 ! regulation of store-operated calcium entry intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002115 ! store-operated calcium entry relationship: positively_regulates GO:0002115 ! store-operated calcium entry created_by: hjd creation_date: 2018-05-10T19:02:40Z [Term] id: GO:0106130 name: purine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate." [PMID:5123876] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups created_by: hjd creation_date: 2018-06-14T17:38:53Z [Term] id: GO:0106134 name: positive regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] is_a: GO:0060452 ! positive regulation of cardiac muscle contraction is_a: GO:0086004 ! regulation of cardiac muscle cell contraction is_a: GO:1903116 ! positive regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0086003 ! cardiac muscle cell contraction relationship: positively_regulates GO:0086003 ! cardiac muscle cell contraction created_by: hjd creation_date: 2018-07-26T16:05:16Z [Term] id: GO:0106135 name: negative regulation of cardiac muscle cell contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0055118 ! negative regulation of cardiac muscle contraction is_a: GO:0086004 ! regulation of cardiac muscle cell contraction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0086003 ! cardiac muscle cell contraction relationship: negatively_regulates GO:0086003 ! cardiac muscle cell contraction created_by: hjd creation_date: 2018-07-26T16:10:17Z [Term] id: GO:0106136 name: lectin-induced modified bacterial internalization namespace: biological_process def: "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:30049880] {comment="GOC:rjd"} synonym: "LIMBI" EXACT [] is_a: GO:0051702 ! interaction with symbiont created_by: hjd creation_date: 2018-08-09T17:27:18Z [Term] id: GO:0106137 name: IkappaB kinase complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the IkappaB kinase complex." [GOC:pga, PMID:12492477] is_a: GO:0044877 ! protein-containing complex binding created_by: hjd creation_date: 2018-08-15T14:05:10Z [Term] id: GO:0106138 name: Sec61 translocon complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Sec61 translocon complex." [GOC:pga, PMID:9792704] is_a: GO:0044877 ! protein-containing complex binding created_by: hjd creation_date: 2018-08-15T14:50:29Z [Term] id: GO:0106139 name: symbiont cell surface namespace: cellular_component def: "The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:rjd, PMID:30049880] synonym: "endosymbiont cell surface" EXACT [] is_a: GO:0044217 ! other organism part relationship: part_of GO:0044216 ! other organism cell created_by: hjd creation_date: 2018-08-15T18:56:57Z [Term] id: GO:0106140 name: P-TEFb complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the P-TEFb complex." [GOC:pga, PMID:18391197] is_a: GO:0044877 ! protein-containing complex binding created_by: hjd creation_date: 2018-08-17T18:17:50Z [Term] id: GO:0106141 name: flavin prenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate." [GOC:imk, PMID:26083743] xref: EC:2.5.1.129 xref: RHEA:37743 is_a: GO:0004659 ! prenyltransferase activity created_by: hjd creation_date: 2018-08-17T18:50:00Z [Term] id: GO:0106142 name: rRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA." [EC:2.1.1.287, PMID:23180764] comment: The m(1)A modification at position 645 in the large rRNA is highly conserved in eukaryotes. synonym: "25S rRNA (adenine(645)-N(1))-methyltransferase" EXACT [EC:2.1.1.287] synonym: "25S rRNA m(1)A(645) methyltransferase" EXACT [EC:2.1.1.287] xref: EC:2.1.1.287 is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity created_by: hjd creation_date: 2018-08-22T20:13:21Z [Term] id: GO:0106143 name: tRNA (m7G46) methyltransferase complex namespace: cellular_component def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat)." [GOC:vw, PMID:15811913, PMID:1738232, PMID:18164779, PMID:18184583] synonym: "Trm8-Trm82 complex" EXACT [] synonym: "tRNA (m7G46) methyltransferase" EXACT [] synonym: "tRNA m7G methylation complex" EXACT [] is_a: GO:0043527 ! tRNA methyltransferase complex created_by: hjd creation_date: 2018-09-07T14:53:29Z [Term] id: GO:0106144 name: fraxetin 5-hydroxylase activity namespace: molecular_function def: "Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20." [GOC:lr, PMID:29581584] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: hjd creation_date: 2018-09-07T18:24:41Z [Term] id: GO:0106145 name: scopoletin 8-hydroxylase activity namespace: molecular_function def: "Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)." [GOC:lr, PMID:29361149, PMID:29581584] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: hjd creation_date: 2018-09-07T18:28:16Z [Term] id: GO:0106146 name: sideretin biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sideretin." [GOC:lr, PMID:29581584] is_a: GO:0009805 ! coumarin biosynthetic process created_by: hjd creation_date: 2018-09-07T18:31:30Z [Term] id: GO:0106147 name: fraxetin biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fraxetin." [GOC:lr, PMID:29581584] is_a: GO:0009805 ! coumarin biosynthetic process created_by: hjd creation_date: 2018-09-07T18:32:47Z [Term] id: GO:0106148 name: 4-hydroxyindole-3- carbonyl nitrile biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside." [GOC:lr, PMID:26352477] is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process created_by: hjd creation_date: 2018-09-10T19:42:16Z [Term] id: GO:0106149 name: indole-3-carbonyl nitrile 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP(+) + H20." [GOC:lr, PMID:26352477] is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: hjd creation_date: 2018-09-10T19:44:15Z [Term] id: GO:0106150 name: zearalenone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals." [GOC:ach, PMID:16517624, PMID:20578001] is_a: GO:0033068 ! macrolide biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process created_by: hjd creation_date: 2018-09-14T17:08:18Z [Term] id: GO:0106151 name: CNBH domain intrinsic ligand binding namespace: molecular_function def: "Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide." [GOC:cvs, PMID:27025590, PMID:29567795] comment: It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids. is_a: GO:0005515 ! protein binding created_by: hjd creation_date: 2018-09-18T20:47:35Z [Term] id: GO:0106153 name: phosphorylated histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone in which a residue has been modified by phosphorylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:mah, PMID:20679485] is_a: GO:0042393 ! histone binding is_a: GO:0140031 ! phosphorylation-dependent protein binding created_by: hjd creation_date: 2018-09-19T17:23:06Z [Term] id: GO:0106154 name: perithecium formation namespace: biological_process def: "The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, GOC:ach, PMID:19547974, PMID:21134480, PMID:25311923] is_a: GO:0120165 ! perithecium development created_by: hjd creation_date: 2018-09-19T19:12:53Z [Term] id: GO:0106155 name: peptidyl-lysine 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2." [GOC:al, PMID:29915238] xref: RHEA:57153 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: hjd creation_date: 2018-11-15T20:09:45Z [Term] id: GO:0106156 name: peptidyl-lysine 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2." [GOC:pde, PMID:24486019] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: hjd creation_date: 2018-11-26T14:59:18Z [Term] id: GO:0106157 name: peptidyl-arginine 3-dioxygenase activity namespace: molecular_function def: "Proposed def: Catalysis of the reaction: protein L-arginie + 2-oxoglutarate + O2 = protein 3-hydroxy-L-arginine + succinate + CO2." [GOC:pde, PMID:29563586] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: hjd creation_date: 2018-11-26T15:05:57Z [Term] id: GO:0106158 name: glycero-3-phosphocholine acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine." [PMID:18430972, PMID:27758859] synonym: "glycero-3-phosphocholine acyltransferase activity" RELATED [] synonym: "glycerophosphocholine O-acyltransferase activity" RELATED [] synonym: "GPCAT activity" RELATED [] xref: BRENDA:EC2.3.1.B36 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: hjd creation_date: 2018-11-26T21:21:03Z [Term] id: GO:0106159 name: regulation of small RNA loading onto RISC namespace: biological_process def: "Any process that modulates the frequency, rate or extent small RNA loading onto RISC." [GOC:ha, PMID:29775584] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070922 ! small RNA loading onto RISC relationship: regulates GO:0070922 ! small RNA loading onto RISC created_by: hjd creation_date: 2018-11-30T15:38:50Z [Term] id: GO:0106160 name: negative regulation of small RNA loading onto RISC namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0060967 ! negative regulation of gene silencing by RNA is_a: GO:0106159 ! regulation of small RNA loading onto RISC intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070922 ! small RNA loading onto RISC relationship: negatively_regulates GO:0070922 ! small RNA loading onto RISC created_by: hjd creation_date: 2018-11-30T15:42:16Z [Term] id: GO:0106161 name: positive regulation of small RNA loading onto RISC namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0106159 ! regulation of small RNA loading onto RISC intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070922 ! small RNA loading onto RISC relationship: positively_regulates GO:0070922 ! small RNA loading onto RISC created_by: hjd creation_date: 2018-11-30T15:45:53Z [Term] id: GO:0106162 name: mRNA N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate." [GOC:sp, PMID:30449621] xref: RHEA:58480 is_a: GO:0008080 ! N-acetyltransferase activity created_by: hjd creation_date: 2018-12-18T19:19:06Z [Term] id: GO:0106163 name: regulation of exonucleolytic catabolism of deadenylated mRNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114] is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA relationship: regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA created_by: hjd creation_date: 2019-01-15T15:33:08Z [Term] id: GO:0106164 name: positive regulation of exonucleolytic catabolism of deadenylated mRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay" [GOC:vw, PMID:30601114] is_a: GO:0106163 ! regulation of exonucleolytic catabolism of deadenylated mRNA is_a: GO:1900153 ! positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA relationship: positively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA created_by: hjd creation_date: 2019-01-15T15:39:19Z [Term] id: GO:0106165 name: negative regulation of exonucleolytic catabolism of deadenylated mRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114] is_a: GO:0106163 ! regulation of exonucleolytic catabolism of deadenylated mRNA is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA relationship: negatively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA created_by: hjd creation_date: 2019-01-15T15:42:13Z [Term] id: GO:0106166 name: spindle pole body anchor namespace: molecular_function def: "Interacting selectively and non-covalently with a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body." [GOC:vw, PMID:9763447] is_a: GO:0043495 ! protein membrane adaptor created_by: hjd creation_date: 2019-01-18T15:57:42Z [Term] id: GO:0106167 name: extracellular ATP signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of extracellular ATP." [GOC:tb, PMID:12948585, PMID:20817461, PMID:29274390] is_a: GO:0007165 ! signal transduction is_a: GO:0071318 ! cellular response to ATP created_by: hjd creation_date: 2019-02-06T19:21:44Z [Term] id: GO:0106172 name: COPI-coated vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a COPI-coated endocytic vesicle." [GOC:pde, PMID:29535154] is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0030137 ! COPI-coated vesicle created_by: hjd creation_date: 2019-02-11T18:04:08Z [Term] id: GO:0106173 name: COPII-coated vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a COPII-coated endocytic vesicle." [GOC:pde, PMID:21172817] is_a: GO:0060205 ! cytoplasmic vesicle lumen created_by: hjd creation_date: 2019-02-11T18:16:22Z [Term] id: GO:0106174 name: phagolysosome vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a phagolysosome." [GOC:pde, PMID:29471269] is_a: GO:0005775 ! vacuolar lumen is_a: GO:0060205 ! cytoplasmic vesicle lumen is_a: GO:0097013 ! phagocytic vesicle lumen relationship: part_of GO:0032010 ! phagolysosome created_by: hjd creation_date: 2019-02-11T19:10:46Z [Term] id: GO:0106175 name: phagolysosome vesicle membrane namespace: cellular_component def: "The lipid bylayer surrounding a phagolysosome." [GOC:pde, PMID:29471269] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0032010 ! phagolysosome created_by: hjd creation_date: 2019-02-11T19:12:53Z [Term] id: GO:0106176 name: clathrin-coated endocytic vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane of a clathrin-coated endocytic vesicle." [GOC:pde, PMID:2516741] is_a: GO:0071682 ! endocytic vesicle lumen relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle created_by: hjd creation_date: 2019-02-12T15:44:51Z [Term] id: GO:0106177 name: cyclic-GMP-AMP hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP." [GOC:sp, PMID:25344812, RHEA:58808] is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides created_by: hjd creation_date: 2019-03-07T21:06:24Z [Term] id: GO:0106178 name: obsolete translocase activity namespace: molecular_function def: "OBSOLETE. Catalysis the movement of ions or molecules across membranes or their separation within membranes." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:41:06Z [Term] id: GO:0106179 name: obsolete translocase activity acting on inorganic cations and their chelates namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.2 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:45:41Z [Term] id: GO:0106180 name: obsolete translocase activty of hydrons namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of hydrons (hydron being the general name for H+ in its natural abundance)." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.1 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:48:44Z [Term] id: GO:0106181 name: obsolete translocase activity acting on inorganic anions namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic anions." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.3 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:50:54Z [Term] id: GO:0106182 name: obsolete translocase activity acting on amino acids and peptides. namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.4 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:52:34Z [Term] id: GO:0106183 name: obsolete translocase activity acting on carbohydrates and their derivatives. namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of carbohydrates and their derivatives." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.5 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:54:25Z [Term] id: GO:0106184 name: obsolete translocation activity acting on other compounds namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of other compounds not included in EC:7.1 through EC:7.5 ." [GOC:hjd, http://www.enzyme-database.org/] comment: This term was made obsolete because the name and scope ( other compounds not included in EC:7.1 through EC:7.5 ) is not good ontological practice. xref: EC:7.6 is_obsolete: true created_by: hjd creation_date: 2019-04-05T15:56:19Z [Term] id: GO:0106185 name: histone H3-K37 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone." [GOC:mah, PMID:30773398] synonym: "histone H3 K37 methylation" EXACT [] synonym: "histone H3K37me" EXACT [] synonym: "histone lysine H3 K37 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation created_by: hjd creation_date: 2019-04-24T14:36:23Z [Term] id: GO:0106186 name: cytoplasmic side of plasma membrane, cell tip namespace: cellular_component def: "The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:vw, PMID:28292899] is_a: GO:0009898 ! cytoplasmic side of plasma membrane relationship: part_of GO:0031520 ! plasma membrane of cell tip created_by: hjd creation_date: 2019-05-01T17:48:02Z [Term] id: GO:0106187 name: obsolete translocase activity acting on hydrons linked to oxidoreductase reactions namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of hydrons linked to an oxidoreduction reaction." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.1.1 is_obsolete: true created_by: hjd creation_date: 2019-05-07T18:04:40Z [Term] id: GO:0106188 name: obsolete translocase activity acting on hydrons linked the hydrolysis of a nucleoside triphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.1.2 is_obsolete: true created_by: hjd creation_date: 2019-05-07T18:09:07Z [Term] id: GO:0106189 name: obsolete translocase activity acting on hydrons linked to the hydrolysis of a diphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.1.3 is_obsolete: true created_by: hjd creation_date: 2019-05-07T18:12:33Z [Term] id: GO:0106190 name: obsolete translocase activity acting on hydrons linked to a decarboxylation reaction namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of hydrons linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.1.4 is_obsolete: true created_by: hjd creation_date: 2019-05-07T18:17:17Z [Term] id: GO:0106191 name: obsolete translocase activity acting on inogranic cations linked to oxidoreductase reactions namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic cations linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.2.1 is_obsolete: true created_by: hjd creation_date: 2019-05-08T16:50:07Z [Term] id: GO:0106192 name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.2.2 is_obsolete: true created_by: hjd creation_date: 2019-05-08T16:52:54Z [Term] id: GO:0106193 name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a diphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.2.3 is_obsolete: true created_by: hjd creation_date: 2019-05-08T16:55:24Z [Term] id: GO:0106194 name: obsolete translocase activity acting on inorganic cations and their chelates linked to a decarboxylation reaction namespace: molecular_function def: "OBSOLETE. Catalysis of the transocation of inorganic cations and their chelates linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.2.4 is_obsolete: true created_by: hjd creation_date: 2019-05-08T16:58:50Z [Term] id: GO:0106195 name: obsolete translocase activty acting on inorganic anions linked to oxidoreductase reactions namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.3.1 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:13:05Z [Term] id: GO:0106196 name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a nucleoside triphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.3.2 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:15:35Z [Term] id: GO:0106197 name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a diphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of inorganic anions llinked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.3.3 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:17:37Z [Term] id: GO:0106198 name: obsolete translocase activity acting on inorganic anions linked to a decarboxylation reaction namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of an inorganic anion linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.3.4 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:20:14Z [Term] id: GO:0106199 name: obsolete translocase activity acting on amino acids and peptides linked to oxidoreductase reactions namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.4.1 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:23:04Z [Term] id: GO:0106200 name: obsolete translocase activity acting on amio acids and peptides linked to the hydrolysis of a nucleoside triphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.4.2 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:25:56Z [Term] id: GO:0106201 name: obsolete translocase activity acting on amino acids and peptides linked to the hydrolysis of a diphosphate namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.4.3 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:28:18Z [Term] id: GO:0106202 name: obsolete translocase activity acting on amino acids and peptides linked to a decarboxylation reaction namespace: molecular_function def: "OBSOLETE. Catalysis of the translocation of amno acids and peptides linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. xref: EC:7.4.4 is_obsolete: true created_by: hjd creation_date: 2019-05-08T18:30:36Z [Term] id: GO:0106210 name: culmorin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris." [CHEBI:143197, GOC:ach, PMID:19880637, PMID:26673640] synonym: "culmorin anabolism" EXACT [] synonym: "culmorin biosynthesis" EXACT [] synonym: "culmorin formation" EXACT [] synonym: "culmorin synthesis" EXACT [] is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0051762 ! sesquiterpene biosynthetic process created_by: hjd creation_date: 2019-05-13T17:30:41Z [Term] id: GO:0106211 name: inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate." [GOC:rn, PMID:29540476] synonym: "5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT [] synonym: "5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT [] synonym: "5-PP-InsP4 activity" EXACT [] xref: RHEA:59500 is_a: GO:0052840 ! inositol diphosphate tetrakisphosphate diphosphatase activity created_by: hjd creation_date: 2019-06-06T19:26:38Z [Term] id: GO:0106212 name: centromere detachment from spindle pole body involved in meiotic chromosome organization namespace: biological_process def: "The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693] synonym: "centromere detachment from SPB involved in meiotic chromosome organization" EXACT [] synonym: "centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT [] is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle created_by: hjd creation_date: 2019-06-25T18:28:39Z [Term] id: GO:0106213 name: kinetochore disassembly involved in meiotic chromosome organization namespace: biological_process def: "The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693] synonym: "kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT [] is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle created_by: hjd creation_date: 2019-06-25T18:31:06Z [Term] id: GO:0106214 name: regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031338 ! regulation of vesicle fusion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048280 ! vesicle fusion with Golgi apparatus relationship: regulates GO:0048280 ! vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:12:22Z [Term] id: GO:0106215 name: negative regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus relationship: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:17:17Z [Term] id: GO:0106216 name: positive regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus relationship: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus created_by: hjd creation_date: 2019-06-27T15:20:59Z [Term] id: GO:0106217 name: tRNA C3-cytosine methylation namespace: biological_process def: "The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine." [PMID:28655767] is_a: GO:0030488 ! tRNA methylation created_by: hjd creation_date: 2019-07-19T19:52:40Z [Term] id: GO:0106218 name: galactosaminogalactan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN)." [PMID:173713, PMID:22102815, PMID:24257745, PMID:26492565, PMID:26932183, PMID:27048799, PMID:30667338] synonym: "GAG biosynthetic process" RELATED [] synonym: "galactosaminogalactan anabolism" RELATED [] synonym: "galactosaminogalactan biosynthesis" RELATED [] synonym: "galactosaminogalactan formation" RELATED [] synonym: "galactosaminogalactan synthesis" RELATED [] is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process created_by: hjd creation_date: 2019-08-05T14:46:56Z [Term] id: GO:0106219 name: zinc ion sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of zinc." [GOC:vw, PMID:31239353] is_a: GO:0008270 ! zinc ion binding is_a: GO:0140299 ! small molecule sensor activity created_by: hjd creation_date: 2019-08-15T16:45:43Z [Term] id: GO:0106220 name: pyocyanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group." [PMID:28715477] synonym: "pyocyanin biosynthetic process" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: hjd creation_date: 2019-08-19T17:15:48Z [Term] id: GO:0106222 name: long noncoding RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a long noncoding RNA (lncRNA)." [PMID:25578728] synonym: "lncRNA binding" EXACT [] is_a: GO:0003723 ! RNA binding created_by: hjd creation_date: 2019-08-27T14:52:58Z [Term] id: GO:0106223 name: germacrene A hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:11299372, PMID:20351109] xref: EC:1.14.14.95 xref: RHEA:30303 is_a: GO:0004497 ! monooxygenase activity created_by: hjd creation_date: 2019-09-06T16:36:25Z [Term] id: GO:0106225 name: peptidyl-lysine 2-hydroxyisobutyrylation namespace: biological_process def: "The 2-hydroxyisobutyrylation of a lysine residue in a protein." [GOC:sp, PMID:29775581] is_a: GO:0043543 ! protein acylation created_by: hjd creation_date: 2019-10-17T18:51:15Z [Term] id: GO:0106226 name: peptide 2-hydroxyisobutyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide." [GOC:sp, PMID:29775581] xref: RHEA:24180 is_a: GO:0016410 ! N-acyltransferase activity created_by: hjd creation_date: 2019-10-17T18:55:24Z [Term] id: GO:0106227 name: peptidyl-lysine glutarylation namespace: biological_process def: "The glutarylation of a lysine residue in a protein." [GOC:sp, PMID:31542297] is_a: GO:0043543 ! protein acylation created_by: hjd creation_date: 2019-10-17T18:57:19Z [Term] id: GO:0106228 name: peptide glutaryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]." [GOC:sp, PMID:31542297] xref: RHEA:18009 is_a: GO:0016410 ! N-acyltransferase activity created_by: hjd creation_date: 2019-10-17T18:58:56Z [Term] id: GO:0106229 name: histone glutaryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone." [GOC:sp, PMID:31542297] is_a: GO:0106228 ! peptide glutaryltransferase activity created_by: hjd creation_date: 2019-10-17T19:01:48Z [Term] id: GO:0106230 name: protein depropionylation namespace: biological_process def: "The removal of a propionyl group from a residue in a peptide or protein." [GOC:sp, PMID:30026585] is_a: GO:0035601 ! protein deacylation created_by: hjd creation_date: 2019-10-17T19:10:50Z [Term] id: GO:0106231 name: protein-propionyllysine depropionylase activity namespace: molecular_function def: "Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:30026585] comment: This reaction is the removal of a propionyl group from a propionylated lysine residue of a protein or peptide. is_a: GO:0016410 ! N-acyltransferase activity created_by: hjd creation_date: 2019-10-18T14:14:47Z [Term] id: GO:0106232 name: hydroxyisourate hydrolase complex namespace: cellular_component def: "A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin." [GOC:bhm, PMID:21795808] synonym: "5-hydroxyisourate hydrolase complex" NARROW [] synonym: "HIU hydrolase complex" NARROW [] synonym: "HIUH complex" NARROW [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm created_by: hjd creation_date: 2019-10-31T16:34:19Z [Term] id: GO:0106233 name: glycosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:ach, PMID:15539076, PMID:28426655, PMID:31341002, PMID:8056787] synonym: "glycosome biogenesis" RELATED [] synonym: "glycosome organisation" EXACT [] synonym: "glycosome organization and biogenesis" RELATED [] is_a: GO:0006996 ! organelle organization created_by: hjd creation_date: 2019-11-01T18:29:46Z [Term] id: GO:0106234 name: outer membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC." [GOC:am, PMID:25267629, PMID:27282389] is_a: GO:0098796 ! membrane protein complex created_by: hjd creation_date: 2019-11-07T19:20:43Z [Term] id: GO:0106235 name: ceramide-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate." [GOC:lb, PubMed:10359651] xref: RHEA:50888 is_a: GO:0042577 ! lipid phosphatase activity created_by: hjd creation_date: 2019-11-21T20:40:39Z [Term] id: GO:0106236 name: rhamnolipid biosynthesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal." [GOC:vw, PMID:28715477] synonym: "rhamnolipid production" RELATED [] is_a: GO:0009247 ! glycolipid biosynthetic process created_by: hjd creation_date: 2019-12-09T18:37:49Z [Term] id: GO:0106237 name: arachidonate 12(R)-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2)=(5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate" [GOC:gap, PMID:10100631, PMID:11256953] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen created_by: hjd creation_date: 2019-12-18T21:03:02Z [Term] id: GO:0106238 name: peregrinol diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O." [GOC:emb, PMID:24990389, PMID:29315936, RHEA:54652] xref: EC:4.2.1.174 xref: RHEA:54652 is_a: GO:0016836 ! hydro-lyase activity created_by: hjd creation_date: 2019-12-19T15:28:28Z [Term] id: GO:0106239 name: 9,13-epoxylabda-14-ene synthase activity namespace: molecular_function def: "Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate." [GOC:emb, PMID:24990389, RHEA:54512] xref: EC:4.2.3.189 xref: RHEA:54512 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates created_by: hjd creation_date: 2019-12-19T16:00:49Z [Term] id: GO:0106240 name: labd-13Z-ene-9,15,16-triol synthase activity namespace: molecular_function def: "Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29315936] is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: hjd creation_date: 2019-12-19T17:43:00Z [Term] id: GO:0106242 name: kolavenyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate." [GOC:eab, PMID:29315936, RHEA:54676] xref: EC:5.5.1.29 xref: RHEA:54676 is_a: GO:0016872 ! intramolecular lyase activity created_by: hjd creation_date: 2019-12-19T18:31:00Z [Term] id: GO:0106243 name: syn-isopimara-7,15-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene." [GOC:emb, PMID:29315936] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates created_by: hjd creation_date: 2019-12-19T19:04:32Z [Term] id: GO:0106244 name: eupatolide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29758164, RHEA:57972] xref: EC:1.14.14.169 xref: RHEA:57972 is_a: GO:0004497 ! monooxygenase activity created_by: hjd creation_date: 2019-12-20T14:50:15Z [Term] id: GO:0110001 name: toxin-antitoxin complex namespace: cellular_component def: "A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon." [GOC:bhm, PMID:16109374, PMID:25093388] comment: An example is YoeB (P69348) in Escherichia coli in PMID:16109374 (inferred by direct evidence). xref: IntAct:EBI-10919614 xref: IntAct:EBI-13949147 xref: IntAct:EBI-13949218 xref: IntAct:EBI-13949593 xref: IntAct:EBI-13949715 xref: IntAct:EBI-13949851 is_a: GO:0005667 ! transcription factor complex is_a: GO:0017053 ! transcriptional repressor complex created_by: kmv [Term] id: GO:0110002 name: regulation of tRNA methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation." [GOC:vw, PMID:23074192] is_a: GO:2000235 ! regulation of tRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030488 ! tRNA methylation relationship: regulates GO:0030488 ! tRNA methylation created_by: kmv [Term] id: GO:0110003 name: regulation of tRNA C5-cytosine methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192] is_a: GO:0110002 ! regulation of tRNA methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002946 ! tRNA C5-cytosine methylation relationship: regulates GO:0002946 ! tRNA C5-cytosine methylation created_by: kmv [Term] id: GO:0110004 name: positive regulation of tRNA methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA methylation." [GOC:vw, PMID:23074192] is_a: GO:0110002 ! regulation of tRNA methylation is_a: GO:2000237 ! positive regulation of tRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030488 ! tRNA methylation relationship: positively_regulates GO:0030488 ! tRNA methylation created_by: kmv [Term] id: GO:0110005 name: positive regulation of tRNA C5-cytosine methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192] is_a: GO:0110003 ! regulation of tRNA C5-cytosine methylation is_a: GO:0110004 ! positive regulation of tRNA methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002946 ! tRNA C5-cytosine methylation relationship: positively_regulates GO:0002946 ! tRNA C5-cytosine methylation created_by: kmv [Term] id: GO:0110008 name: ncRNA deadenylation namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed ncRNA." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:26950371] is_a: GO:0034660 ! ncRNA metabolic process created_by: kmv [Term] id: GO:0110009 name: formin-nucleated actin cable organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable." [GOC:mah] is_a: GO:0061572 ! actin filament bundle organization created_by: kmv [Term] id: GO:0110010 name: basolateral protein secretion namespace: biological_process def: "The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base." [GOC:ha, PMID:27404358] is_a: GO:0009306 ! protein secretion created_by: kmv [Term] id: GO:0110011 name: regulation of basement membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071711 ! basement membrane organization relationship: regulates GO:0071711 ! basement membrane organization created_by: kmv [Term] id: GO:0110012 name: protein localization to P-body namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a P-body." [GOC:mah, PMID:28031482] synonym: "protein localisation to P-body" EXACT [GOC:mah] synonym: "protein localization to cytoplasmic mRNA processing body" EXACT [] synonym: "protein localization to P body" EXACT [] is_a: GO:0033365 ! protein localization to organelle created_by: kmv creation_date: 2017-05-03T14:04:51Z [Term] id: GO:0110013 name: positive regulation of aggregation involved in sorocarp development namespace: biological_process def: "Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031152 ! aggregation involved in sorocarp development relationship: positively_regulates GO:0031152 ! aggregation involved in sorocarp development created_by: kmv creation_date: 2017-05-10T12:52:46Z [Term] id: GO:0110014 name: negative regulation of aggregation involved in sorocarp development namespace: biological_process def: "Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031152 ! aggregation involved in sorocarp development relationship: negatively_regulates GO:0031152 ! aggregation involved in sorocarp development created_by: kmv creation_date: 2017-05-10T12:53:12Z [Term] id: GO:0110015 name: positive regulation of elastin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0060310 ! regulation of elastin catabolic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060309 ! elastin catabolic process relationship: positively_regulates GO:0060309 ! elastin catabolic process created_by: kmv creation_date: 2017-05-10T14:54:12Z [Term] id: GO:0110016 name: B-WICH complex namespace: cellular_component def: "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184] comment: An example is BAZ1B (Q9UIG0) in human in PMID:16603771 (by IPI). xref: IntAct:EBI-13952597 is_a: GO:0070603 ! SWI/SNF superfamily-type complex relationship: part_of GO:0005730 ! nucleolus created_by: kmv creation_date: 2017-05-26T19:53:53Z [Term] id: GO:0110017 name: cap-independent translational initiation of linear mRNA namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [GOC:kmv] is_a: GO:0002190 ! cap-independent translational initiation created_by: kmv creation_date: 2017-06-08T15:13:55Z [Term] id: GO:0110018 name: cap-independent translational initiation of circular RNA namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082] synonym: "cap-independent translational initiation of circRNA" EXACT [] is_a: GO:0002190 ! cap-independent translational initiation created_by: kmv creation_date: 2017-06-08T15:22:35Z [Term] id: GO:0110019 name: IRES-dependent translational initiation of circular RNA namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082] synonym: "IRES-dependent translational initiation of circRNA" EXACT [] is_a: GO:0110018 ! cap-independent translational initiation of circular RNA created_by: kmv creation_date: 2017-06-08T15:36:38Z [Term] id: GO:0110020 name: regulation of actomyosin structure organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031032 ! actomyosin structure organization relationship: regulates GO:0031032 ! actomyosin structure organization created_by: kmv creation_date: 2017-06-20T19:28:58Z [Term] id: GO:0110021 name: cardiac muscle myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0051450 ! myoblast proliferation created_by: kmv creation_date: 2017-06-29T14:35:24Z [Term] id: GO:0110022 name: regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0110021 ! cardiac muscle myoblast proliferation relationship: regulates GO:0110021 ! cardiac muscle myoblast proliferation created_by: kmv creation_date: 2017-06-29T15:11:47Z [Term] id: GO:0110023 name: negative regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000818 ! negative regulation of myoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation relationship: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation created_by: kmv creation_date: 2017-06-29T15:18:30Z [Term] id: GO:0110024 name: positive regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000288 ! positive regulation of myoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation relationship: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation created_by: kmv creation_date: 2017-06-29T15:24:16Z [Term] id: GO:0110025 name: DNA strand resection involved in replication fork processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0035312 ! 5'-3' exodeoxyribonuclease activity relationship: part_of GO:0031297 ! replication fork processing created_by: kmv creation_date: 2017-07-05T14:43:36Z [Term] id: GO:0110026 name: regulation of DNA strand resection involved in replication fork processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0110025 ! DNA strand resection involved in replication fork processing relationship: regulates GO:0110025 ! DNA strand resection involved in replication fork processing created_by: kmv creation_date: 2017-07-05T18:21:06Z [Term] id: GO:0110027 name: negative regulation of DNA strand resection involved in replication fork processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0110026 ! regulation of DNA strand resection involved in replication fork processing is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing relationship: negatively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing created_by: kmv creation_date: 2017-07-05T18:39:49Z [Term] id: GO:0110028 name: positive regulation of mitotic spindle organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization." [GOC:bhm, PMID:17576815] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007052 ! mitotic spindle organization relationship: positively_regulates GO:0007052 ! mitotic spindle organization created_by: kmv creation_date: 2017-07-06T14:14:08Z [Term] id: GO:0110029 name: negative regulation of meiosis I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:vw] is_a: GO:0045835 ! negative regulation of meiotic nuclear division is_a: GO:0060631 ! regulation of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007127 ! meiosis I relationship: negatively_regulates GO:0007127 ! meiosis I created_by: kmv creation_date: 2017-07-12T18:47:33Z [Term] id: GO:0110030 name: regulation of G2/MI transition of meiotic cell cycle namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw] is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008315 ! G2/MI transition of meiotic cell cycle relationship: regulates GO:0008315 ! G2/MI transition of meiotic cell cycle created_by: kmv creation_date: 2017-07-12T19:02:19Z [Term] id: GO:0110031 name: negative regulation of G2/MI transition of meiotic cell cycle namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle relationship: negatively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle created_by: kmv creation_date: 2017-07-12T20:36:35Z [Term] id: GO:0110032 name: positive regulation of G2/MI transition of meiotic cell cycle namespace: biological_process def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle relationship: positively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle created_by: kmv creation_date: 2017-07-12T20:40:54Z [Term] id: GO:0110033 name: regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:al, PMID:24297439] synonym: "regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:1902659 ! regulation of glucose mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway relationship: regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway created_by: kmv creation_date: 2017-07-17T20:22:20Z [Term] id: GO:0110034 name: negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway." [GOC:al, PMID:24297439] synonym: "negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0110033 ! regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway is_a: GO:1902660 ! negative regulation of glucose mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway relationship: negatively_regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway created_by: kmv creation_date: 2017-07-17T20:35:55Z [Term] id: GO:0110035 name: rDNA spacer replication fork barrier binding, bending namespace: molecular_function def: "The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:al, GOC:vw, PMID:27035982] is_a: GO:0043110 ! rDNA spacer replication fork barrier binding is_a: GO:0044374 ! sequence-specific DNA binding, bending created_by: kmv creation_date: 2017-07-17T21:09:50Z [Term] id: GO:0110036 name: C2 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes." [GOC:sl, PMID:24882364] is_a: GO:0019904 ! protein domain specific binding created_by: kmv creation_date: 2017-07-20T20:45:56Z [Term] id: GO:0110037 name: regulation of nematode male tail tip morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized." [GOC:rz, PMID:28068334] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045138 ! nematode male tail tip morphogenesis relationship: regulates GO:0045138 ! nematode male tail tip morphogenesis created_by: kmv creation_date: 2017-07-24T20:21:34Z [Term] id: GO:0110038 name: negative regulation of nematode male tail tip morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045138 ! nematode male tail tip morphogenesis relationship: negatively_regulates GO:0045138 ! nematode male tail tip morphogenesis created_by: kmv creation_date: 2017-07-24T20:29:00Z [Term] id: GO:0110039 name: positive regulation of nematode male tail tip morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045138 ! nematode male tail tip morphogenesis relationship: positively_regulates GO:0045138 ! nematode male tail tip morphogenesis created_by: kmv creation_date: 2017-07-24T20:32:58Z [Term] id: GO:0110040 name: pharynx morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pharynx are generated and organized." [GOC:rz, PMID:20805556] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: kmv creation_date: 2017-07-24T20:51:28Z [Term] id: GO:0110041 name: regulation of pharynx morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized." [GOC:rz, PMID:20805556] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0110040 ! pharynx morphogenesis relationship: regulates GO:0110040 ! pharynx morphogenesis created_by: kmv creation_date: 2017-07-24T21:00:20Z [Term] id: GO:0110042 name: negative regulation of pharynx morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0110041 ! regulation of pharynx morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0110040 ! pharynx morphogenesis relationship: negatively_regulates GO:0110040 ! pharynx morphogenesis created_by: kmv creation_date: 2017-07-24T21:05:08Z [Term] id: GO:0110043 name: positive regulation of pharynx morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0110041 ! regulation of pharynx morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0110040 ! pharynx morphogenesis relationship: positively_regulates GO:0110040 ! pharynx morphogenesis created_by: kmv creation_date: 2017-07-24T21:09:48Z [Term] id: GO:0110044 name: regulation of cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle relationship: regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle created_by: kmv creation_date: 2017-08-08T21:24:45Z [Term] id: GO:0110045 name: negative regulation of cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0110044 ! regulation of cell cycle switching, mitotic to meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle relationship: negatively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle created_by: kmv creation_date: 2017-08-08T21:33:28Z [Term] id: GO:0110046 name: signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle namespace: biological_process def: "A signal transduction process that contributes to cell cycle switching, mitotic to meiotic cell cycle." [GOC:al, PMID:17674143] is_a: GO:0022402 ! cell cycle process is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle relationship: part_of GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle created_by: kmv creation_date: 2017-08-09T12:28:08Z [Term] id: GO:0110050 name: deaminated glutathione amidase activity namespace: molecular_function def: "Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O = 2-oxoglutarate + L-cysteinylglycine" [GOC:ka, PMID:28373563] comment: N-(4-oxoglutarate)-L-cysteinylglycine = deaminated glutathione is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: kmv creation_date: 2017-08-31T19:19:11Z [Term] id: GO:0110051 name: metabolite repair namespace: biological_process def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563] is_a: GO:0044237 ! cellular metabolic process created_by: kmv creation_date: 2017-09-08T15:16:01Z [Term] id: GO:0110052 name: toxic metabolite repair namespace: biological_process def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, GOC:vw, PMID:23334546] is_a: GO:0110051 ! metabolite repair is_a: GO:1990748 ! cellular detoxification created_by: kmv creation_date: 2017-09-08T15:19:16Z [Term] id: GO:0110053 name: regulation of actin filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007015 ! actin filament organization relationship: regulates GO:0007015 ! actin filament organization created_by: kmv creation_date: 2017-09-20T19:52:57Z [Term] id: GO:0110054 name: regulation of actin filament annealing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:15743909, PMID:19244341] is_a: GO:0110053 ! regulation of actin filament organization created_by: kmv creation_date: 2017-09-20T20:07:58Z [Term] id: GO:0110055 name: negative regulation of actin filament annealing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:15743909] is_a: GO:0110054 ! regulation of actin filament annealing created_by: kmv creation_date: 2017-09-20T20:10:55Z [Term] id: GO:0110056 name: positive regulation of actin filament annealing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:19244341] is_a: GO:0110054 ! regulation of actin filament annealing created_by: kmv creation_date: 2017-09-20T20:13:09Z [Term] id: GO:0110057 name: regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045601 ! regulation of endothelial cell differentiation is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060837 ! blood vessel endothelial cell differentiation relationship: regulates GO:0060837 ! blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:32:09Z [Term] id: GO:0110058 name: positive regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045603 ! positive regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation relationship: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:38:19Z [Term] id: GO:0110059 name: negative regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation relationship: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation created_by: kmv creation_date: 2017-10-23T14:47:29Z [Term] id: GO:0110061 name: regulation of angiotensin-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038166 ! angiotensin-activated signaling pathway relationship: regulates GO:0038166 ! angiotensin-activated signaling pathway created_by: kmv creation_date: 2017-10-26T17:37:37Z [Term] id: GO:0110062 name: negative regulation of angiotensin-activated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038166 ! angiotensin-activated signaling pathway relationship: negatively_regulates GO:0038166 ! angiotensin-activated signaling pathway created_by: kmv creation_date: 2017-10-26T17:42:17Z [Term] id: GO:0110063 name: positive regulation of angiotensin-activated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038166 ! angiotensin-activated signaling pathway relationship: positively_regulates GO:0038166 ! angiotensin-activated signaling pathway created_by: kmv creation_date: 2017-10-26T17:47:37Z [Term] id: GO:0110064 name: lncRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length." [GOC:al, PMID:24493644] synonym: "lncRNA breakdown" EXACT [] synonym: "lncRNA catabolism" EXACT [] synonym: "lncRNA degradation" EXACT [] is_a: GO:0034661 ! ncRNA catabolic process created_by: kmv creation_date: 2017-11-06T13:49:49Z [Term] id: GO:0110065 name: regulation of interphase mitotic telomere clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919] synonym: "regulation of mitotic telomere clustering during interphase" EXACT [] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120110 ! interphase mitotic telomere clustering relationship: regulates GO:0120110 ! interphase mitotic telomere clustering created_by: kmv creation_date: 2017-11-17T22:03:40Z [Term] id: GO:0110066 name: negative regulation of interphase mitotic telomere clustering namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919] synonym: "negative regulation of mitotic telomere clustering during interphase" EXACT [] synonym: "telomere dispersion during interphase" EXACT [GOC:vw, PMID:25778919] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0110065 ! regulation of interphase mitotic telomere clustering intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120110 ! interphase mitotic telomere clustering relationship: negatively_regulates GO:0120110 ! interphase mitotic telomere clustering created_by: kmv creation_date: 2017-11-17T22:11:59Z [Term] id: GO:0110067 name: ammonium transmembrane transporter complex namespace: cellular_component def: "High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other." [GOC:bhm, PMID:17026539, PMID:23463773] synonym: "AMT1 complex" NARROW [GOC:bhm] xref: IntAct:EBI-16426073 is_a: GO:1902495 ! transmembrane transporter complex created_by: kmv creation_date: 2017-11-20T15:21:10Z [Term] id: GO:0110068 name: glucosylglycerate phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate" [GOC:imk, PMID:28754708] is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity created_by: kmv creation_date: 2017-11-21T21:50:10Z [Term] id: GO:0110069 name: syncytial embryo cellularization namespace: biological_process def: "The separation of a syncytial embryo into individual cells." [GOC:ha, PMID:27226317] is_a: GO:0007349 ! cellularization is_a: GO:0051301 ! cell division relationship: part_of GO:0009790 ! embryo development created_by: kmv creation_date: 2017-11-22T19:59:19Z [Term] id: GO:0110070 name: cellularization cleavage furrow namespace: cellular_component def: "A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells." [GOC:ha, PMID:27226317] is_a: GO:0032154 ! cleavage furrow created_by: kmv creation_date: 2017-11-22T20:10:14Z [Term] id: GO:0110071 name: cellularization cleavage furrow invagination front namespace: cellular_component def: "The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane." [GOC:ha, PMID:27226317] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0110070 ! cellularization cleavage furrow created_by: kmv creation_date: 2017-11-22T20:13:21Z [Term] id: GO:0110072 name: apical constriction involved in ventral furrow formation namespace: biological_process def: "The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [GOC:ha, PMID:28495958] is_a: GO:0003384 ! apical constriction involved in gastrulation intersection_of: GO:0003383 ! apical constriction intersection_of: part_of GO:0007370 ! ventral furrow formation relationship: part_of GO:0007370 ! ventral furrow formation created_by: kmv creation_date: 2017-12-06T17:04:49Z [Term] id: GO:0110073 name: regulation of apical constriction involved in ventral furrow formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0110072 ! apical constriction involved in ventral furrow formation relationship: regulates GO:0110072 ! apical constriction involved in ventral furrow formation created_by: kmv creation_date: 2017-12-06T17:30:29Z [Term] id: GO:0110074 name: positive regulation of apical constriction involved in ventral furrow formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0110073 ! regulation of apical constriction involved in ventral furrow formation is_a: GO:1903116 ! positive regulation of actin filament-based movement is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0110072 ! apical constriction involved in ventral furrow formation relationship: positively_regulates GO:0110072 ! apical constriction involved in ventral furrow formation created_by: kmv creation_date: 2017-12-06T17:39:00Z [Term] id: GO:0110075 name: regulation of ferroptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097707 ! ferroptosis relationship: regulates GO:0097707 ! ferroptosis created_by: kmv creation_date: 2018-01-11T17:51:48Z [Term] id: GO:0110076 name: negative regulation of ferroptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0110075 ! regulation of ferroptosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097707 ! ferroptosis relationship: negatively_regulates GO:0097707 ! ferroptosis created_by: kmv creation_date: 2018-01-11T18:00:05Z [Term] id: GO:0110077 name: vesicle-mediated intercellular transport namespace: biological_process def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] is_a: GO:0010496 ! intercellular transport is_a: GO:0016192 ! vesicle-mediated transport created_by: kmv creation_date: 2018-01-29T14:46:52Z [Term] id: GO:0110078 name: TTT complex namespace: cellular_component def: "A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209)." [GOC:lnp, PMID:20810650, PMID:22505622, PMID:28827813] synonym: "Tel2-Tti1-Tti2" EXACT [GOC:lnp, PMID:28827813] synonym: "TELO2-TTI1-TTI2" EXACT [GOC:lnp] synonym: "Triple T complex" EXACT [GOC:lnp, PMID:20810650] xref: IntAct:EBI-16631004 is_a: GO:0032991 ! protein-containing complex created_by: kmv creation_date: 2018-01-29T21:39:52Z [Term] id: GO:0110079 name: regulation of placenta blood vessel development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:1901342 ! regulation of vasculature development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060674 ! placenta blood vessel development relationship: regulates GO:0060674 ! placenta blood vessel development created_by: kmv creation_date: 2018-02-01T14:49:12Z [Term] id: GO:0110080 name: positive regulation of placenta blood vessel development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:0110079 ! regulation of placenta blood vessel development is_a: GO:1904018 ! positive regulation of vasculature development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060674 ! placenta blood vessel development relationship: positively_regulates GO:0060674 ! placenta blood vessel development created_by: kmv creation_date: 2018-02-01T14:55:30Z [Term] id: GO:0110081 name: negative regulation of placenta blood vessel development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] is_a: GO:0110079 ! regulation of placenta blood vessel development is_a: GO:1901343 ! negative regulation of vasculature development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060674 ! placenta blood vessel development relationship: negatively_regulates GO:0060674 ! placenta blood vessel development created_by: kmv creation_date: 2018-02-01T15:01:11Z [Term] id: GO:0110082 name: regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] is_a: GO:1901900 ! regulation of protein localization to cell division site is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly relationship: regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly created_by: kmv creation_date: 2018-02-01T19:25:06Z [Term] id: GO:0110083 name: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly is_a: GO:1903501 ! positive regulation of mitotic actomyosin contractile ring assembly is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly relationship: positively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly created_by: kmv creation_date: 2018-02-01T19:30:03Z [Term] id: GO:0110084 name: negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly relationship: negatively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly created_by: kmv creation_date: 2018-02-01T19:33:51Z [Term] id: GO:0110085 name: mitotic actomyosin contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:vw, PMID:27505246] is_a: GO:0005826 ! actomyosin contractile ring created_by: kmv creation_date: 2018-02-12T17:04:02Z [Term] id: GO:0110086 name: meiotic actomyosin contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis." [GOC:vw, PMID:22526418] is_a: GO:0005826 ! actomyosin contractile ring created_by: kmv creation_date: 2018-02-12T17:26:17Z [Term] id: GO:0110087 name: suppression by virus of host protease activator activity namespace: biological_process def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protease activator activity." [PMID:23303392] is_a: GO:0039507 ! suppression by virus of host molecular function created_by: kmv creation_date: 2018-02-12T20:17:29Z [Term] id: GO:0110088 name: hippocampal neuron apoptotic process namespace: biological_process def: "Any apoptotic process that occurs in a hippocampal neuron." [GOC:sl, PMID:18940801] is_a: GO:0051402 ! neuron apoptotic process created_by: kmv creation_date: 2018-02-13T21:06:23Z [Term] id: GO:0110089 name: regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0110088 ! hippocampal neuron apoptotic process relationship: regulates GO:0110088 ! hippocampal neuron apoptotic process created_by: kmv creation_date: 2018-02-13T21:18:29Z [Term] id: GO:0110090 name: positive regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0110088 ! hippocampal neuron apoptotic process relationship: positively_regulates GO:0110088 ! hippocampal neuron apoptotic process created_by: kmv creation_date: 2018-02-13T21:22:18Z [Term] id: GO:0110091 name: negative regulation of hippocampal neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0110088 ! hippocampal neuron apoptotic process relationship: negatively_regulates GO:0110088 ! hippocampal neuron apoptotic process created_by: kmv creation_date: 2018-02-13T21:25:01Z [Term] id: GO:0110092 name: nucleus leading edge namespace: cellular_component def: "The area of a motile nucleus closest to the direction of movement." [GOC:al, GOC:mah, GOC:vw, PMID:15030757, PMID:24335254] synonym: "horsetail nucleus leading edge" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005634 ! nucleus created_by: kmv creation_date: 2018-02-14T22:39:58Z [Term] id: GO:0110093 name: nucleus lagging edge namespace: cellular_component def: "The area of a motile nucleus furthest from the direction of movement." [GOC:kmv, PMID:24335254] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005634 ! nucleus created_by: kmv creation_date: 2018-02-14T22:56:12Z [Term] id: GO:0110094 name: polyphosphate-mediated signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal." [GOC:rjd, PMID:27519410, PMID:28584190] synonym: "polyphosphate signaling" EXACT [GOC:rjd] is_a: GO:0007267 ! cell-cell signaling created_by: kmv creation_date: 2018-02-15T16:42:30Z [Term] id: GO:0110095 name: cellular detoxification of aldehyde namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw, PMID:25656103] is_a: GO:1990748 ! cellular detoxification relationship: part_of GO:0110096 ! cellular response to aldehyde created_by: kmv creation_date: 2018-02-16T21:19:20Z [Term] id: GO:0110096 name: cellular response to aldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus." [GOC:vw, PMID:25656103] is_a: GO:0010033 ! response to organic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: kmv creation_date: 2018-02-16T21:29:18Z [Term] id: GO:0110097 name: regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:0090279 ! regulation of calcium ion import is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0036444 ! calcium import into the mitochondrion relationship: regulates GO:0036444 ! calcium import into the mitochondrion created_by: kmv creation_date: 2018-02-28T00:33:51Z [Term] id: GO:0110098 name: positive regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:0090280 ! positive regulation of calcium ion import is_a: GO:0110097 ! regulation of calcium import into the mitochondrion is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0036444 ! calcium import into the mitochondrion relationship: positively_regulates GO:0036444 ! calcium import into the mitochondrion created_by: kmv creation_date: 2018-02-28T00:39:13Z [Term] id: GO:0110099 name: negative regulation of calcium import into the mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion." [GOC:sl, PMID:24085037] is_a: GO:0090281 ! negative regulation of calcium ion import is_a: GO:0110097 ! regulation of calcium import into the mitochondrion is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0036444 ! calcium import into the mitochondrion relationship: negatively_regulates GO:0036444 ! calcium import into the mitochondrion created_by: kmv creation_date: 2018-02-28T00:42:06Z [Term] id: GO:0110100 name: spindle pole body separation namespace: biological_process def: "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble." [GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization created_by: kmv creation_date: 2018-03-06T15:09:28Z [Term] id: GO:0110101 name: L-valine transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-valine into the vacuole across the vacuolar membrane." [GOC:al, PMID:20944394] is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole is_a: GO:1903785 ! L-valine transmembrane transport created_by: kmv creation_date: 2018-03-14T19:56:06Z [Term] id: GO:0110102 name: chloroplast ribulose bisphosphate carboxylase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a chloroplast ribulose bisphosphate carboxylase complex." [GOC:tb, PMID:29396988] synonym: "chloroplast rubisco assembly" EXACT [GOC:tb] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: kmv creation_date: 2018-03-15T17:24:14Z [Term] id: GO:0110103 name: RNA polymerase II termination complex namespace: cellular_component def: "A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end." [GOC:lnp, PMID:23200120, PMID:25722373] comment: In S. cerevisiae, this complex is formed by RAI1 and RAT1; in H. sapiens it is formed by Twi12, Xrn2 and Tan1. synonym: "TXT complex" EXACT [PMID:23084833] xref: IntAct:EBI-16426399 is_a: GO:1905354 ! exoribonuclease complex created_by: kmv creation_date: 2018-03-16T18:55:17Z [Term] id: GO:0110104 name: mRNA alternative polyadenylation namespace: biological_process def: "The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085] is_a: GO:1900363 ! regulation of mRNA polyadenylation created_by: kmv creation_date: 2018-03-27T19:26:56Z [Term] id: GO:0110105 name: mRNA cleavage and polyadenylation specificity factor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex." [GOC:mah, PMID:27401558] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0031123 ! RNA 3'-end processing created_by: kmv creation_date: 2018-04-13T19:05:17Z [Term] id: GO:0110107 name: regulation of imaginal disc-derived wing vein specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007474 ! imaginal disc-derived wing vein specification relationship: regulates GO:0007474 ! imaginal disc-derived wing vein specification created_by: kmv creation_date: 2018-07-05T13:44:08Z [Term] id: GO:0110108 name: positive regulation of imaginal disc-derived wing vein specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007474 ! imaginal disc-derived wing vein specification relationship: positively_regulates GO:0007474 ! imaginal disc-derived wing vein specification created_by: kmv creation_date: 2018-07-05T13:52:31Z [Term] id: GO:0110109 name: negative regulation of imaginal disc-derived wing vein specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007474 ! imaginal disc-derived wing vein specification relationship: negatively_regulates GO:0007474 ! imaginal disc-derived wing vein specification created_by: kmv creation_date: 2018-07-05T13:55:37Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009887 ! animal organ morphogenesis relationship: positively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009887 ! animal organ morphogenesis relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110112 name: regulation of lipid transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032409 ! regulation of transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005319 ! lipid transporter activity relationship: regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T18:53:55Z [Term] id: GO:0110113 name: positive regulation of lipid transporter activity namespace: biological_process def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0110112 ! regulation of lipid transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0005319 ! lipid transporter activity relationship: positively_regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:14:13Z [Term] id: GO:0110114 name: negative regulation of lipid transporter activity namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0110112 ! regulation of lipid transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0005319 ! lipid transporter activity relationship: negatively_regulates GO:0005319 ! lipid transporter activity created_by: kmv creation_date: 2018-07-06T19:21:44Z [Term] id: GO:0110115 name: Cdr2 medial cortical node complex namespace: cellular_component def: "A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase." [GOC:vw, PMID:29514920] synonym: "interphase cortical node" EXACT [GOC:vw] synonym: "interphase node" EXACT [GOC:vw] is_a: GO:1902911 ! protein kinase complex relationship: part_of GO:0071341 ! medial cortical node created_by: kmv creation_date: 2018-07-10T14:02:26Z [Term] id: GO:0110116 name: regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001751 ! compound eye photoreceptor cell differentiation relationship: regulates GO:0001751 ! compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:08:49Z [Term] id: GO:0110117 name: positive regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation relationship: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:13:28Z [Term] id: GO:0110118 name: negative regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation relationship: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation created_by: kmv creation_date: 2018-07-16T18:15:52Z [Term] id: GO:0110119 name: positive regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:25510864] is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance relationship: positively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance created_by: kmv creation_date: 2018-07-27T14:13:47Z [Term] id: GO:0110120 name: gamma-tubulin complex localization to nuclear side of mitotic spindle pole body namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body." [GOC:vw, PMID:19942852] is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body created_by: kmv creation_date: 2018-07-27T15:42:46Z [Term] id: GO:0110121 name: gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body." [GOC:vw, PMID:19001497] is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body created_by: kmv creation_date: 2018-07-27T15:49:05Z [Term] id: GO:0110122 name: myotube cell migration namespace: biological_process def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742] is_a: GO:0014812 ! muscle cell migration created_by: kmv creation_date: 2018-08-22T20:58:09Z [Term] id: GO:0110123 name: regulation of myotube cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0110122 ! myotube cell migration relationship: regulates GO:0110122 ! myotube cell migration created_by: kmv creation_date: 2018-08-22T21:06:53Z [Term] id: GO:0110124 name: positive regulation of myotube cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0110122 ! myotube cell migration relationship: positively_regulates GO:0110122 ! myotube cell migration created_by: kmv creation_date: 2018-08-22T21:09:38Z [Term] id: GO:0110125 name: negative regulation of myotube cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0110122 ! myotube cell migration relationship: negatively_regulates GO:0110122 ! myotube cell migration created_by: kmv creation_date: 2018-08-22T21:12:47Z [Term] id: GO:0110126 name: phloem loading namespace: biological_process def: "The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:lr, PMID:19025382] is_a: GO:0010233 ! phloem transport created_by: kmv creation_date: 2018-09-07T21:24:54Z [Term] id: GO:0110127 name: phloem unloading namespace: biological_process def: "The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:19025382] is_a: GO:0010233 ! phloem transport created_by: kmv creation_date: 2018-09-07T21:33:07Z [Term] id: GO:0110128 name: phloem sucrose unloading namespace: biological_process def: "The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:30018170] is_a: GO:0015770 ! sucrose transport is_a: GO:0110127 ! phloem unloading created_by: kmv creation_date: 2018-09-07T21:38:52Z [Term] id: GO:0110129 name: SHREC2 complex namespace: cellular_component def: "A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2." [GOC:mah, PMID:19111658] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0090568 ! nuclear transcriptional repressor complex relationship: has_part GO:0070824 ! SHREC complex created_by: kmv creation_date: 2018-09-25T21:25:41Z [Term] id: GO:0110130 name: ribitol-5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate." [GOC:rn, PMID:30240188] xref: RHEA:47648 is_a: GO:0016791 ! phosphatase activity created_by: kmv creation_date: 2018-10-08T19:47:57Z [Term] id: GO:0110131 name: Aim21-Tda2 complex namespace: cellular_component def: "A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables." [GOC:rn, PMID:28706108, PMID:29467252] synonym: "Aim21/Tda2 complex" EXACT [] xref: ComplexPortal:CPX-3541 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030479 ! actin cortical patch created_by: kmv creation_date: 2018-10-09T21:08:36Z [Term] id: GO:0110132 name: regulation of CRISPR-cas system namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099048 ! CRISPR-cas system relationship: regulates GO:0099048 ! CRISPR-cas system created_by: kmv creation_date: 2018-11-14T17:13:16Z [Term] id: GO:0110133 name: negative regulation of CRISPR-cas system namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0110132 ! regulation of CRISPR-cas system intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0099048 ! CRISPR-cas system relationship: negatively_regulates GO:0099048 ! CRISPR-cas system created_by: kmv creation_date: 2018-11-14T17:23:07Z [Term] id: GO:0110134 name: meiotic drive namespace: biological_process def: "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis." [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907] is_a: GO:0022414 ! reproductive process created_by: kmv creation_date: 2019-01-02T17:37:09Z [Term] id: GO:0110135 name: Norrin signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state." [GOC:BHF, GOC:rl, PMID:15035989, PMID:17955262] is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling created_by: kmv creation_date: 2019-01-18T19:07:18Z [Term] id: GO:0110136 name: protein-RNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex." [GOC:rn, PMID:19737519, PMID:20542003, PMID:24240281] is_a: GO:0034367 ! protein-containing complex remodeling is_a: GO:0071826 ! ribonucleoprotein complex subunit organization created_by: kmv creation_date: 2019-01-22T19:23:17Z [Term] id: GO:0110137 name: regulation of imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized." [GOC:ha, PMID:25329825] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007480 ! imaginal disc-derived leg morphogenesis relationship: regulates GO:0007480 ! imaginal disc-derived leg morphogenesis created_by: kmv creation_date: 2019-02-12T15:31:25Z [Term] id: GO:0110138 name: positive regulation of imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis relationship: positively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis created_by: kmv creation_date: 2019-02-12T15:37:05Z [Term] id: GO:0110139 name: negative regulation of imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis relationship: negatively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis created_by: kmv creation_date: 2019-02-12T15:40:09Z [Term] id: GO:0110140 name: flagellum attachment zone organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [GOC:ach, PMID:26776656] synonym: "FAZ organization" EXACT [] synonym: "flagellum attachment zone organisation" EXACT [] is_a: GO:0034330 ! cell junction organization created_by: kmv creation_date: 2019-03-04T19:55:50Z [Term] id: GO:0110141 name: L-glutamate import into mitochondrion namespace: biological_process def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0051938 ! L-glutamate import is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: kmv creation_date: 2019-04-24T19:13:46Z [Term] id: GO:0110142 name: ubiquinone biosynthesis complex namespace: cellular_component def: "The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K." [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758] synonym: "CoQ metabolon" EXACT [PMID:28927698] synonym: "Ubi complex" EXACT [PMID:30686758] is_a: GO:0032991 ! protein-containing complex created_by: kmv creation_date: 2019-04-25T15:48:21Z [Term] id: GO:0110143 name: magnetosome namespace: cellular_component def: "A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles." [GOC:aa, PMID:27620945] is_a: GO:0043226 ! organelle created_by: kmv creation_date: 2019-05-30T17:31:21Z [Term] id: GO:0110144 name: obsolete magnetosome part namespace: cellular_component def: "OBSOLETE. Any constituent part of a magnetosome, a membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria." [GOC:aa, PMID:27620945] is_obsolete: true consider: GO:0110143 created_by: kmv creation_date: 2019-05-30T17:36:02Z [Term] id: GO:0110145 name: magnetosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a magnetosome." [GOC:aa, PMID:27620945] is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0110143 ! magnetosome relationship: part_of GO:0110143 ! magnetosome created_by: kmv creation_date: 2019-05-30T17:42:14Z [Term] id: GO:0110146 name: magnetosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a magnetosome." [GOC:aa, PMID:27620945] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0110143 ! magnetosome created_by: kmv creation_date: 2019-05-30T17:51:09Z [Term] id: GO:0110147 name: protein maturation by nickel ion transfer namespace: biological_process def: "A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation." [GOC:al, PMID:24115911] is_a: GO:0051604 ! protein maturation created_by: kmv creation_date: 2019-05-31T14:41:20Z [Term] id: GO:0110148 name: biomineralization namespace: biological_process def: "The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products." [GOC:aa, PMID:24395694, PMID:28229486] synonym: "biomineral formation" NARROW [] synonym: "biomineralisation" EXACT [] synonym: "mineralisation" EXACT [] synonym: "mineralization" EXACT [] xref: Wikipedia:Biomineralization is_a: GO:0008150 ! biological_process created_by: kmv creation_date: 2019-06-10T17:55:28Z [Term] id: GO:0110149 name: regulation of biomineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] synonym: "regulation of biomineral formation" NARROW [] synonym: "regulation of biomineralisation" EXACT [] synonym: "regulation of mineralisation" EXACT [] synonym: "regulation of mineralization" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0110148 ! biomineralization relationship: regulates GO:0110148 ! biomineralization created_by: kmv creation_date: 2019-06-10T18:06:59Z [Term] id: GO:0110150 name: negative regulation of biomineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] synonym: "negative regulation of biomineral formation" NARROW [] synonym: "negative regulation of biomineralisation" EXACT [] synonym: "negative regulation of mineralisation" EXACT [] synonym: "negative regulation of mineralization" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0110149 ! regulation of biomineralization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0110148 ! biomineralization relationship: negatively_regulates GO:0110148 ! biomineralization created_by: kmv creation_date: 2019-06-10T18:12:24Z [Term] id: GO:0110151 name: positive regulation of biomineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] synonym: "positive regulation of biomineral formation" NARROW [] synonym: "positive regulation of biomineralisation" EXACT [] synonym: "positive regulation of mineralisation" EXACT [] synonym: "positive regulation of mineralization" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0110149 ! regulation of biomineralization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0110148 ! biomineralization relationship: positively_regulates GO:0110148 ! biomineralization created_by: kmv creation_date: 2019-06-10T18:18:01Z [Term] id: GO:0110152 name: RNA NAD-cap (NAD-forming) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058] comment: This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides created_by: kmv creation_date: 2019-07-08T15:55:11Z [Term] id: GO:0110153 name: RNA NAD-cap (NMN-forming) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)." [GOC:sp, PMID:25533955, PMID:31101919] comment: This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides created_by: kmv creation_date: 2019-07-08T17:15:59Z [Term] id: GO:0110154 name: RNA decapping namespace: biological_process def: "Cleavage of the 5'-cap of an RNA." [GOC:sp, PMID:25533955, PMID:31101919] is_a: GO:0016070 ! RNA metabolic process created_by: kmv creation_date: 2019-07-08T17:23:59Z [Term] id: GO:0110155 name: NAD-cap decapping namespace: biological_process def: "Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919] is_a: GO:0110154 ! RNA decapping created_by: kmv creation_date: 2019-07-08T17:27:56Z [Term] id: GO:0110156 name: methylguanosine-cap decapping namespace: biological_process def: "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA." [PMID:23287066] is_a: GO:0110154 ! RNA decapping created_by: kmv creation_date: 2019-07-08T17:31:07Z [Term] id: GO:0110157 name: reelin complex namespace: cellular_component def: "An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain." [GOC:bhm, PMID:21844191, PMID:28887403] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005615 ! extracellular space created_by: kmv creation_date: 2019-07-15T15:10:58Z [Term] id: GO:0110158 name: calpain complex namespace: cellular_component def: "A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate." [GOC:bhm, PMID:10639123] synonym: "M-calpain" NARROW [] synonym: "mu-calpain" NARROW [] is_a: GO:0008303 ! caspase complex relationship: part_of GO:0005737 ! cytoplasm created_by: kmv creation_date: 2019-07-15T18:30:51Z [Term] id: GO:0110159 name: regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:1901673 ! regulation of mitotic spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:10:26Z [Term] id: GO:0110160 name: negative regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902845 ! negative regulation of mitotic spindle elongation is_a: GO:1905831 ! negative regulation of spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:18:32Z [Term] id: GO:0110161 name: positive regulation of mitotic spindle formation (spindle phase one) namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902846 ! positive regulation of mitotic spindle elongation is_a: GO:1905832 ! positive regulation of spindle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) relationship: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) created_by: kmv creation_date: 2019-08-12T15:21:08Z [Term] id: GO:0110162 name: regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0032888 ! regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) relationship: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) created_by: kmv creation_date: 2019-08-12T15:26:01Z [Term] id: GO:0110163 name: negative regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) is_a: GO:1902845 ! negative regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) relationship: negatively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) created_by: kmv creation_date: 2019-08-12T15:29:43Z [Term] id: GO:0110164 name: positive regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) is_a: GO:1902846 ! positive regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) relationship: positively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) created_by: kmv creation_date: 2019-08-12T15:32:20Z [Term] id: GO:0110165 name: cellular anatomical entity namespace: cellular_component def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv] is_a: GO:0005575 ! cellular_component created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120001 name: apical plasma membrane urothelial plaque namespace: cellular_component def: "A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array." [GOC:krc, PMID:21468280, PMID:21887288] synonym: "asymmetric unit membrane" EXACT [] synonym: "AUM" RELATED [] is_a: GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0016324 ! apical plasma membrane created_by: kchris creation_date: 2017-02-23T21:10:27Z [Term] id: GO:0120002 name: fusiform vesicle namespace: cellular_component def: "A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder." [GOC:krc, PMID:21468280, PMID:21887288] is_a: GO:0031410 ! cytoplasmic vesicle created_by: kchris creation_date: 2017-02-23T21:12:27Z [Term] id: GO:0120003 name: hinge region between urothelial plaques of apical plasma membrane namespace: cellular_component def: "A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane." [GOC:krc, PMID:21468280, PMID:21887288] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0016324 ! apical plasma membrane created_by: kchris creation_date: 2017-02-23T22:13:27Z [Term] id: GO:0120006 name: regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905962 ! glutamatergic neuron differentiation relationship: regulates GO:1905962 ! glutamatergic neuron differentiation created_by: kchris creation_date: 2017-03-01T16:10:27Z [Term] id: GO:0120007 name: negative regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905962 ! glutamatergic neuron differentiation relationship: negatively_regulates GO:1905962 ! glutamatergic neuron differentiation created_by: kchris creation_date: 2017-03-01T16:25:50Z [Term] id: GO:0120008 name: positive regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905962 ! glutamatergic neuron differentiation relationship: positively_regulates GO:1905962 ! glutamatergic neuron differentiation created_by: kchris creation_date: 2017-03-01T16:35:45Z [Term] id: GO:0120009 name: intermembrane lipid transfer namespace: biological_process def: "The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] is_a: GO:0006869 ! lipid transport is_a: GO:0061024 ! membrane organization created_by: kchris creation_date: 2017-03-16T20:30:42Z [Term] id: GO:0120010 name: intermembrane phospholipid transfer namespace: biological_process def: "The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] is_a: GO:0015914 ! phospholipid transport is_a: GO:0120009 ! intermembrane lipid transfer created_by: kchris creation_date: 2017-03-16T20:56:03Z [Term] id: GO:0120011 name: intermembrane sterol transfer namespace: biological_process def: "The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] is_a: GO:0015918 ! sterol transport is_a: GO:0120009 ! intermembrane lipid transfer created_by: kchris creation_date: 2017-03-16T22:15:40Z [Term] id: GO:0120012 name: intermembrane sphingolipid transfer namespace: biological_process def: "The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0120009 ! intermembrane lipid transfer created_by: kchris creation_date: 2017-03-16T22:20:45Z [Term] id: GO:0120013 name: lipid transfer activity namespace: molecular_function def: "Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane lipid transfer activity" NARROW [] synonym: "lipid carrier activity" EXACT [] is_a: GO:0005319 ! lipid transporter activity created_by: kchris creation_date: 2017-03-17T03:17:29Z [Term] id: GO:0120014 name: phospholipid transfer activity namespace: molecular_function def: "Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane phospholipid transfer activity" NARROW [] synonym: "phospholipid carrier activity" EXACT [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0120013 ! lipid transfer activity relationship: has_part GO:0005543 ! phospholipid binding created_by: kchris creation_date: 2017-03-17T03:34:17Z [Term] id: GO:0120015 name: sterol transfer activity namespace: molecular_function def: "Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane sterol transfer activity" NARROW [] synonym: "sterol carrier activity" EXACT [] is_a: GO:0015248 ! sterol transporter activity is_a: GO:0120013 ! lipid transfer activity relationship: has_part GO:0032934 ! sterol binding created_by: kchris creation_date: 2017-03-17T03:46:28Z [Term] id: GO:0120016 name: sphingolipid transfer activity namespace: molecular_function def: "Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane sphingolipid transfer activity" NARROW [] synonym: "sphingolipid carrier activity" NARROW [] is_a: GO:0046624 ! sphingolipid transporter activity is_a: GO:0120013 ! lipid transfer activity relationship: has_part GO:0046625 ! sphingolipid binding created_by: kchris creation_date: 2017-03-17T03:52:30Z [Term] id: GO:0120017 name: ceramide transfer activity namespace: molecular_function alt_id: GO:0035620 def: "Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "ceramide carrier activity" EXACT [] synonym: "ceramide transporter activity" BROAD [] synonym: "intermembrane ceramide transfer activity" NARROW [] is_a: GO:0120016 ! sphingolipid transfer activity relationship: has_part GO:0097001 ! ceramide binding created_by: kchris creation_date: 2010-12-08T12:32:50Z [Term] id: GO:0120019 name: phosphatidylcholine transfer activity namespace: molecular_function def: "Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane phosphatidylcholine transfer activity" NARROW [] synonym: "phosphatidylcholine carrier activity" EXACT [] is_a: GO:0008525 ! phosphatidylcholine transporter activity is_a: GO:0120014 ! phospholipid transfer activity relationship: has_part GO:0031210 ! phosphatidylcholine binding created_by: kchris creation_date: 2017-03-17T04:22:47Z [Term] id: GO:0120020 name: cholesterol transfer activity namespace: molecular_function alt_id: GO:0017127 def: "Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "cholesterol carrier activity" EXACT [] synonym: "cholesterol transporter activity" BROAD [] synonym: "intermembrane cholesterol transfer activity" NARROW [] is_a: GO:0120015 ! sterol transfer activity relationship: has_part GO:0015485 ! cholesterol binding created_by: kchris creation_date: 2017-03-17T04:46:12Z [Term] id: GO:0120021 name: oxysterol transfer activity namespace: molecular_function def: "Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] synonym: "intermembrane oxysterol transfer activity" NARROW [] synonym: "oxysterol carrier activity" EXACT [] is_a: GO:0120015 ! sterol transfer activity relationship: has_part GO:0008142 ! oxysterol binding created_by: kchris creation_date: 2017-03-17T04:50:30Z [Term] id: GO:0120022 name: glucagon binding namespace: molecular_function def: "Interacting selectively and non-covalently with glucagon, a polypeptide hormone involved in glucose response. It is produced by pancreatic alpha cells and raises the concentration of glucose in the blood." [GOC:cvs] is_a: GO:0017046 ! peptide hormone binding created_by: kchris creation_date: 2017-03-17T14:46:29Z [Term] id: GO:0120023 name: somatostatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin." [GOC:cvs, PMID:20472043] is_a: GO:0017046 ! peptide hormone binding created_by: kchris creation_date: 2017-03-17T14:54:21Z [Term] id: GO:0120024 name: glucagon-like peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with glucagon-like peptide, a antihyperglycemic hormone. Glucagon-like peptide is derived from the glucagon gene produced by pancreatic alpha cells." [GOC:cvs] is_a: GO:0017046 ! peptide hormone binding created_by: kchris creation_date: 2017-03-17T14:57:26Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: has_part GO:0098590 ! plasma membrane region relationship: has_part GO:0098590 ! plasma membrane region created_by: kchris creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120026 name: host cell uropod namespace: cellular_component def: "A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [PMID:24965475] synonym: "host cell uropodium" EXACT [] is_a: GO:0044157 ! host cell projection created_by: kchris creation_date: 2017-03-22T21:33:31Z [Term] id: GO:0120027 name: regulation of osmosensory signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0106049 ! regulation of cellular response to osmotic stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007231 ! osmosensory signaling pathway relationship: regulates GO:0007231 ! osmosensory signaling pathway created_by: kchris creation_date: 2017-03-31T14:45:01Z [Term] id: GO:0120028 name: negative regulation of osmosensory signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0120027 ! regulation of osmosensory signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007231 ! osmosensory signaling pathway relationship: negatively_regulates GO:0007231 ! osmosensory signaling pathway created_by: kchris creation_date: 2017-03-31T15:00:28Z [Term] id: GO:0120029 name: proton export across plasma membrane namespace: biological_process def: "The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:9762918] synonym: "hydrogen ion export across plasma membrane" EXACT [] synonym: "hydrogen ion export from cell" BROAD [] synonym: "proton export across plasma membrane" EXACT [] synonym: "proton export from cell" BROAD [] is_a: GO:0140115 ! export across plasma membrane is_a: GO:1902600 ! proton transmembrane transport created_by: kchris creation_date: 2017-03-31T17:39:03Z [Term] id: GO:0120030 name: positive regulation of cilium beat frequency involved in ciliary motility namespace: biological_process def: "Any process that activates or increases the frequency of cilium beating involved in ciliary motility." [PMID:28035044] is_a: GO:0060296 ! regulation of cilium beat frequency involved in ciliary motility created_by: kchris creation_date: 2017-04-19T14:32:16Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: kchris creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly created_by: kchris creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120036 ! plasma membrane bounded cell projection organization relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization created_by: kchris creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization created_by: kchris creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120038 name: obsolete plasma membrane bounded cell projection part namespace: cellular_component def: "OBSOLETE. Any constituent part of a plasma membrane bounded cell projection, a prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_obsolete: true consider: GO:0120025 created_by: kchris creation_date: 2017-04-28T17:20:43Z [Term] id: GO:0120039 name: plasma membrane bounded cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] is_a: GO:0048858 ! cell projection morphogenesis created_by: kchris creation_date: 2017-04-28T23:39:37Z [Term] id: GO:0120040 name: regulation of macrophage proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061517 ! macrophage proliferation relationship: regulates GO:0061517 ! macrophage proliferation created_by: kchris creation_date: 2017-05-10T20:38:19Z [Term] id: GO:0120041 name: positive regulation of macrophage proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0120040 ! regulation of macrophage proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061517 ! macrophage proliferation relationship: positively_regulates GO:0061517 ! macrophage proliferation created_by: kchris creation_date: 2017-05-10T20:45:01Z [Term] id: GO:0120042 name: negative regulation of macrophage proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0120040 ! regulation of macrophage proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061517 ! macrophage proliferation relationship: negatively_regulates GO:0061517 ! macrophage proliferation created_by: kchris creation_date: 2017-05-10T20:51:40Z [Term] id: GO:0120043 name: stereocilium shaft namespace: cellular_component def: "The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle." [GOC:krc, PMID:20170899] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032420 ! stereocilium created_by: kchris creation_date: 2017-05-15T20:38:32Z [Term] id: GO:0120044 name: stereocilium base namespace: cellular_component def: "The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium." [GOC:krc, PMID:20170899] synonym: "stereocilium taper" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032420 ! stereocilium created_by: kchris creation_date: 2017-05-15T20:45:06Z [Term] id: GO:0120045 name: stereocilium maintenance namespace: biological_process def: "The organization process that preserves a stereocilium in a stable functional or structural state." [GOC:krc, PMID:27693694] is_a: GO:0043954 ! cellular component maintenance is_a: GO:0060122 ! inner ear receptor cell stereocilium organization created_by: kchris creation_date: 2017-05-15T20:55:13Z [Term] id: GO:0120046 name: regulation of protein localization to medial cortical node namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789] is_a: GO:0106011 ! regulation of protein localization to medial cortex intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902577 ! protein localization to medial cortical node relationship: regulates GO:1902577 ! protein localization to medial cortical node created_by: kchris creation_date: 2017-06-02T17:29:23Z [Term] id: GO:0120047 name: positive regulation of protein localization to medial cortical node namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789] is_a: GO:0106012 ! positive regulation of protein localization to medial cortex is_a: GO:0120046 ! regulation of protein localization to medial cortical node intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902577 ! protein localization to medial cortical node relationship: positively_regulates GO:1902577 ! protein localization to medial cortical node created_by: kchris creation_date: 2017-06-02T17:30:38Z [Term] id: GO:0120048 name: U6 snRNA (adenine-(43)-N(6))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA" [PMID:28525753] is_a: GO:0008173 ! RNA methyltransferase activity created_by: kchris creation_date: 2017-06-02T20:37:40Z [Term] id: GO:0120049 name: snRNA (adenine-N6)-methylation namespace: biological_process def: "The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule." [PMID:28525753] is_a: GO:0040031 ! snRNA modification created_by: kchris creation_date: 2017-06-02T20:56:51Z [Term] id: GO:0120053 name: ribitol beta-1,4-xylosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R." [PMID:27733679] is_a: GO:0035252 ! UDP-xylosyltransferase activity created_by: kchris creation_date: 2017-06-13T19:35:01Z [Term] id: GO:0120054 name: intestinal motility namespace: biological_process def: "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth)." [GOC:sl, PMID:15890336] is_a: GO:0022600 ! digestive system process created_by: kchris creation_date: 2017-06-13T20:42:24Z [Term] id: GO:0120055 name: small intestinal transit namespace: biological_process def: "Migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] synonym: "small bowel transit" EXACT [] synonym: "small intestine transit" EXACT [] is_a: GO:0120054 ! intestinal motility created_by: kchris creation_date: 2017-06-13T20:46:41Z [Term] id: GO:0120056 name: large intestinal transit namespace: biological_process def: "Migration of ingested material along the length of the large intestine." [GOC:sl, PMID:28157109] synonym: "colon transit" EXACT [] synonym: "colonic transit" EXACT [] synonym: "large bowel transit" EXACT [] synonym: "large intestine transit" EXACT [] is_a: GO:0120054 ! intestinal motility created_by: kchris creation_date: 2017-06-13T20:52:01Z [Term] id: GO:0120057 name: regulation of small intestinal transit namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] synonym: "regulation of small bowel transit" EXACT [] synonym: "regulation of small intestine transit" EXACT [] is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120055 ! small intestinal transit relationship: regulates GO:0120055 ! small intestinal transit created_by: kchris creation_date: 2017-06-13T20:56:46Z [Term] id: GO:0120058 name: positive regulation of small intestinal transit namespace: biological_process def: "Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] synonym: "positive regulation of small bowel transit" EXACT [] synonym: "positive regulation of small intestine transit" EXACT [] is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0120057 ! regulation of small intestinal transit intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0120055 ! small intestinal transit relationship: positively_regulates GO:0120055 ! small intestinal transit created_by: kchris creation_date: 2017-06-13T20:58:23Z [Term] id: GO:0120059 name: negative regulation of small intestinal transit namespace: biological_process def: "Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] synonym: "negative regulation of small bowel transit" EXACT [] synonym: "negative regulation of small intestine transit" EXACT [] is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:0120057 ! regulation of small intestinal transit intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120055 ! small intestinal transit relationship: negatively_regulates GO:0120055 ! small intestinal transit created_by: kchris creation_date: 2017-06-13T20:58:23Z [Term] id: GO:0120060 name: regulation of gastric emptying namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] synonym: "regulation of small bowel emptying" EXACT [] synonym: "regulation of small intestine emptying" EXACT [] is_a: GO:1905333 ! regulation of gastric motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035483 ! gastric emptying relationship: regulates GO:0035483 ! gastric emptying created_by: kchris creation_date: 2017-06-13T21:47:16Z [Term] id: GO:0120061 name: negative regulation of gastric emptying namespace: biological_process def: "Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:0120060 ! regulation of gastric emptying intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035483 ! gastric emptying relationship: negatively_regulates GO:0035483 ! gastric emptying created_by: kchris creation_date: 2017-06-13T21:54:49Z [Term] id: GO:0120062 name: positive regulation of gastric emptying namespace: biological_process def: "Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:0120060 ! regulation of gastric emptying intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035483 ! gastric emptying relationship: positively_regulates GO:0035483 ! gastric emptying created_by: kchris creation_date: 2017-06-13T21:55:08Z [Term] id: GO:0120063 name: stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach." [GOC:sl, PMID:15890336] is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction created_by: kchris creation_date: 2017-06-13T22:20:16Z [Term] id: GO:0120064 name: stomach pylorus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach." [GOC:sl, PMID:15890336] is_a: GO:0014828 ! distal stomach smooth muscle contraction created_by: kchris creation_date: 2017-06-13T22:32:04Z [Term] id: GO:0120065 name: pyloric antrum smooth muscle contraction namespace: biological_process def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach." [GOC:sl, PMID:15890336] synonym: "antrum smooth muscle contraction" EXACT [] is_a: GO:0120064 ! stomach pylorus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T22:36:20Z [Term] id: GO:0120066 name: pyloric canal smooth muscle contraction namespace: biological_process def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter." [GOC:sl, PMID:15890336] is_a: GO:0120064 ! stomach pylorus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T22:37:51Z [Term] id: GO:0120067 name: pyloric sphincter smooth muscle contraction namespace: biological_process def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum." [GOC:sl, PMID:15890336] is_a: GO:0120064 ! stomach pylorus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T22:38:26Z [Term] id: GO:0120068 name: regulation of stomach fundus smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014825 ! stomach fundus smooth muscle contraction relationship: regulates GO:0014825 ! stomach fundus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:22:52Z [Term] id: GO:0120069 name: positive regulation of stomach fundus smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014825 ! stomach fundus smooth muscle contraction relationship: positively_regulates GO:0014825 ! stomach fundus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:27:25Z [Term] id: GO:0120070 name: negative regulation of stomach fundus smooth muscle contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014825 ! stomach fundus smooth muscle contraction relationship: negatively_regulates GO:0014825 ! stomach fundus smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:27:40Z [Term] id: GO:0120071 name: regulation of pyloric antrum smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0120065 ! pyloric antrum smooth muscle contraction relationship: regulates GO:0120065 ! pyloric antrum smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:32:39Z [Term] id: GO:0120072 name: positive regulation of pyloric antrum smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction relationship: positively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:32:56Z [Term] id: GO:0120073 name: negative regulation of pyloric antrum smooth muscle contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction relationship: negatively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction created_by: kchris creation_date: 2017-06-13T23:33:11Z [Term] id: GO:0120074 name: regulation of endocardial cushion cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061443 ! endocardial cushion cell differentiation relationship: regulates GO:0061443 ! endocardial cushion cell differentiation created_by: kchris creation_date: 2017-06-26T23:32:00Z [Term] id: GO:0120075 name: positive regulation of endocardial cushion cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061443 ! endocardial cushion cell differentiation relationship: positively_regulates GO:0061443 ! endocardial cushion cell differentiation created_by: kchris creation_date: 2017-06-26T23:36:59Z [Term] id: GO:0120076 name: negative regulation of endocardial cushion cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061443 ! endocardial cushion cell differentiation relationship: negatively_regulates GO:0061443 ! endocardial cushion cell differentiation created_by: kchris creation_date: 2017-06-26T23:37:23Z [Term] id: GO:0120077 name: angiogenic sprout fusion namespace: biological_process def: "Def: The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis." [GOC:cvs, PMID:28264837] synonym: "angiogenic sprout fusion" EXACT [] synonym: "blood vessel anastomosis" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: has_part GO:0120078 ! cell adhesion involved in sprouting angiogenesis relationship: part_of GO:0002040 ! sprouting angiogenesis created_by: kchris creation_date: 2017-06-27T21:16:55Z [Term] id: GO:0120078 name: cell adhesion involved in sprouting angiogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a vascular network.\n\n\nDef: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network." [GOC:cvs, PMID:28264837] synonym: "cell adhesion involved in blood vessel anastomosis" EXACT [] synonym: "cell adhesion involved in vascular anastomosis" RELATED [] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: part_of GO:0120077 ! angiogenic sprout fusion relationship: part_of GO:0120077 ! angiogenic sprout fusion created_by: kchris creation_date: 2017-06-27T21:29:47Z [Term] id: GO:0120079 name: regulation of microfilament motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471] synonym: "regulation of actin filament motor activity" EXACT [] synonym: "regulation of actin-filament motor activity" EXACT [] synonym: "regulation of muscle motor activity" NARROW [] synonym: "regulation of myosin ATPase activity" RELATED [] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000146 ! microfilament motor activity relationship: regulates GO:0000146 ! microfilament motor activity created_by: kchris creation_date: 2017-07-05T20:53:49Z [Term] id: GO:0120080 name: negative regulation of microfilament motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471] synonym: "negative regulation of actin filament motor activity" EXACT [] synonym: "negative regulation of actin-filament motor activity" EXACT [] synonym: "negative regulation of muscle motor activity" NARROW [] synonym: "negative regulation of myosin ATPase activity" RELATED [] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0120079 ! regulation of microfilament motor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000146 ! microfilament motor activity relationship: negatively_regulates GO:0000146 ! microfilament motor activity created_by: kchris creation_date: 2017-07-05T21:36:47Z [Term] id: GO:0120081 name: positive regulation of microfilament motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471] synonym: "positive regulation of actin filament motor activity" EXACT [] synonym: "positive regulation of actin-filament motor activity" EXACT [] synonym: "positive regulation of muscle motor activity" NARROW [] synonym: "positive regulation of myosin ATPase activity" BROAD [] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0120079 ! regulation of microfilament motor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000146 ! microfilament motor activity relationship: positively_regulates GO:0000146 ! microfilament motor activity created_by: kchris creation_date: 2017-07-05T21:48:56Z [Term] id: GO:0120082 name: smooth endoplasmic reticulum cisterna namespace: cellular_component def: "A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005790 ! smooth endoplasmic reticulum relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network created_by: kchris creation_date: 2017-07-05T23:32:11Z [Term] id: GO:0120083 name: rough endoplasmic reticulum cisterna namespace: cellular_component def: "A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network created_by: kchris creation_date: 2017-07-05T23:38:49Z [Term] id: GO:0120084 name: endothelial tip cell filopodium assembly namespace: biological_process def: "The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout." [GOC:cvs, PMID:28264837] is_a: GO:0046847 ! filopodium assembly created_by: kchris creation_date: 2017-07-07T18:05:10Z [Term] id: GO:0120085 name: transposon integration involved in RNA-mediated transposition namespace: biological_process def: "Any transposon integration that contributes to a process of RNA-mediated transposition." [GOC:mah, PMID:26358720] synonym: "retrotransposon integration" EXACT [] is_a: GO:0070893 ! transposon integration intersection_of: GO:0070893 ! transposon integration intersection_of: part_of GO:0032197 ! transposition, RNA-mediated relationship: part_of GO:0032197 ! transposition, RNA-mediated created_by: kchris creation_date: 2017-07-07T22:17:32Z [Term] id: GO:0120086 name: (3S)-(+)-asterisca-2(9),6-diene synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene" [CHEBI:137531, PMID:27862766] synonym: "asterisca-2(9),6-diene synthase activity" BROAD [] is_a: GO:0010334 ! sesquiterpene synthase activity created_by: kchris creation_date: 2017-08-02T14:55:38Z [Term] id: GO:0120091 name: jasmonic acid hydrolase namespace: molecular_function def: "Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid." [PMID:28559313, PMID:28760569] synonym: "2-oxoglutarate dioxygenase" BROAD [] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds created_by: kchris creation_date: 2017-08-18T23:25:52Z [Term] id: GO:0120092 name: crotonyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." [PMID:28803779] xref: RHEA:45584 is_a: GO:0016836 ! hydro-lyase activity created_by: kchris creation_date: 2017-08-22T20:13:55Z [Term] id: GO:0120093 name: regulation of peptidyl-lysine crotonylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein." [PMID:28803779] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140066 ! peptidyl-lysine crotonylation relationship: regulates GO:0140066 ! peptidyl-lysine crotonylation created_by: kchris creation_date: 2017-08-22T20:25:51Z [Term] id: GO:0120094 name: negative regulation of peptidyl-lysine crotonylation namespace: biological_process def: "Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein." [PMID:28803779] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0120093 ! regulation of peptidyl-lysine crotonylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140066 ! peptidyl-lysine crotonylation relationship: negatively_regulates GO:0140066 ! peptidyl-lysine crotonylation created_by: kchris creation_date: 2017-08-22T20:36:36Z [Term] id: GO:0120095 name: vacuole-isolation membrane contact site namespace: cellular_component def: "An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome." [PMID:23549786] synonym: "vacuole-IM contact site" EXACT [] synonym: "vacuole-phagophore contact site" EXACT [] synonym: "VICS" RELATED [] is_a: GO:0044232 ! organelle membrane contact site created_by: kchris creation_date: 2017-09-18T20:01:35Z [Term] id: GO:0120097 name: glycosylphosphatidylinositol-mannosyltransferase II complex namespace: cellular_component def: "A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p." [GOC:bhm, PMID:17615295] synonym: "GPI-MT-I complex" RELATED [] xref: IntAct:EBI-16398134 is_a: GO:0031501 ! mannosyltransferase complex relationship: part_of GO:0005783 ! endoplasmic reticulum created_by: kchris creation_date: 2017-09-18T20:51:56Z [Term] id: GO:0120098 name: procentriole namespace: cellular_component def: "A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primative land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells." [GOC:bhm, GOC:krc, PMID:18620859, PMID:21289083, PMID:25047614] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: kchris creation_date: 2017-09-28T21:22:56Z [Term] id: GO:0120099 name: procentriole replication complex namespace: cellular_component def: "A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates." [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597] xref: IntAct:EBI-15188467 xref: IntAct:EBI-15189349 xref: IntAct:EBI-15316456 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: kchris creation_date: 2017-09-28T21:41:34Z [Term] id: GO:0120100 name: bacterial-type flagellum motor namespace: cellular_component def: "A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009425 ! bacterial-type flagellum basal body created_by: kchris creation_date: 2017-10-03T15:44:35Z [Term] id: GO:0120101 name: bacterial-type flagellum stator complex namespace: cellular_component def: "A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] synonym: "bacterial-type flagellum motor force generator complex" EXACT [PMID:24697492] synonym: "bacterial-type flagellum torque generator complex" EXACT [DOI:10.1002/9780470015902.a0000744.pub4] is_a: GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0120100 ! bacterial-type flagellum motor created_by: kchris creation_date: 2017-10-03T16:06:16Z [Term] id: GO:0120102 name: bacterial-type flagellum secretion apparatus namespace: cellular_component def: "A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] synonym: "bacterial-type flagellum export apparatus" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0009425 ! bacterial-type flagellum basal body created_by: kchris creation_date: 2017-10-03T16:13:24Z [Term] id: GO:0120103 name: centriolar subdistal appendage namespace: cellular_component def: "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092] synonym: "subdistal appendage of basal body" EXACT [GOC:krc] synonym: "subdistal appendage of centriole" EXACT [GOC:krc] synonym: "subdistal appendage of mother centriole" EXACT [GOC:krc] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005929 ! cilium created_by: kchris creation_date: 2017-10-10T15:31:40Z [Term] id: GO:0120104 name: actomyosin contractile ring, proximal layer namespace: cellular_component def: "The region of the actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005826 ! actomyosin contractile ring created_by: kchris creation_date: 2017-10-11T22:49:58Z [Term] id: GO:0120105 name: actomyosin contractile ring, intermediate layer namespace: cellular_component def: "The region of the actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005826 ! actomyosin contractile ring created_by: kchris creation_date: 2017-10-11T22:54:40Z [Term] id: GO:0120106 name: actomyosin contractile ring, distal actin filament layer namespace: cellular_component def: "The region of the actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005826 ! actomyosin contractile ring created_by: kchris creation_date: 2017-10-11T22:56:44Z [Term] id: GO:0120107 name: bacterial-type flagellum rotor complex namespace: cellular_component def: "The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:25251856] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0120100 ! bacterial-type flagellum motor created_by: kchris creation_date: 2017-10-17T20:54:45Z [Term] id: GO:0120108 name: DNA-3'-diphospho-5'-guanosine diphosphatase namespace: molecular_function def: "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP." [PMID:26007660] synonym: "DNA-3'pp5'G guanylate hydrolase" EXACT [] xref: EC:3.1.12.2 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds created_by: kchris creation_date: 2017-10-17T22:12:59Z [Term] id: GO:0120109 name: mitotic telomere clustering and tethering at nuclear periphery namespace: biological_process def: "The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle." [PMID:25778919] is_a: GO:0034397 ! telomere localization created_by: kchris creation_date: 2017-11-01T18:04:37Z [Term] id: GO:0120110 name: interphase mitotic telomere clustering namespace: biological_process def: "The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope." [PMID:25778919] comment: It is likely that both intra chromosome telomere clustering and inter-chromosome occur because a single focus is sometimes observed, although this has yet to be proven. synonym: "mitotic telomere clustering during interphase" EXACT [] is_a: GO:0034397 ! telomere localization relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery created_by: kchris creation_date: 2017-11-01T18:09:08Z [Term] id: GO:0120111 name: neuron projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0043005 ! neuron projection relationship: part_of GO:0043005 ! neuron projection created_by: kchris creation_date: 2017-11-01T18:58:12Z [Term] id: GO:0120112 name: UDP-glucose transmembrane transport into endoplasmic reticulum namespace: biological_process def: "The directed movement of UDP-glucose from cytosol to endoplasmic reticulum." [PMID:27587357] is_a: GO:0015786 ! UDP-glucose transmembrane transport is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport created_by: kchris creation_date: 2017-11-02T15:56:51Z [Term] id: GO:0120113 name: cytoplasm to vacuole transport by the NVT pathway namespace: biological_process def: "A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe." [PMID:26365378] synonym: "cytoplasm to vacuole targeting" BROAD [] synonym: "cytoplasm-to-vacuole targeting" BROAD [] synonym: "protein localization by the Nbr1-mediated vacuolar targeting pathway" EXACT [] synonym: "protein localization by the NVT pathway" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole relationship: has_part GO:0006624 ! vacuolar protein processing created_by: kchris creation_date: 2017-11-03T16:07:55Z [Term] id: GO:0120114 name: Sm-like protein family complex namespace: cellular_component def: "A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles." [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834] is_a: GO:0032991 ! protein-containing complex created_by: kchris creation_date: 2017-11-06T18:46:43Z [Term] id: GO:0120115 name: Lsm2-8 complex namespace: cellular_component def: "A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular the U6 snRNA, and also to unspliced transcripts localized within the nucleus." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202] xref: IntAct:EBI-16419597 is_a: GO:0120114 ! Sm-like protein family complex created_by: kchris creation_date: 2017-11-06T18:56:22Z [Term] id: GO:0120116 name: glucagon processing namespace: biological_process def: "The formation of mature glucagon by proteolysis of the precursor proglucagon." [PMID:28719828] is_a: GO:0016486 ! peptide hormone processing created_by: kchris creation_date: 2017-11-08T19:31:42Z [Term] id: GO:0120117 name: T cell meandering migration namespace: biological_process def: "The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs)." [GOC:add, GOC:krc, PMID:25083865] synonym: "lymph node surveillance" RELATED [] synonym: "T cell meandering search" EXACT [] is_a: GO:0072678 ! T cell migration created_by: kchris creation_date: 2017-11-22T18:13:01Z [Term] id: GO:0120118 name: flagella connector namespace: cellular_component def: "A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum" [PMID:11641501, PMID:15075226, PMID:16954145, PMID:26820516] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. is_a: GO:0030054 ! cell junction created_by: kchris creation_date: 2017-12-11T22:24:17Z [Term] id: GO:0120119 name: flagellum attachment zone namespace: cellular_component def: "A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [PMID:10361731, PMID:16414276, PMID:17945531, PMID:20541452, PMID:25972344, PMID:2606941, PMID:26746239, PMID:26776656] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. synonym: "FAZ" RELATED [] is_a: GO:0070161 ! anchoring junction created_by: kchris creation_date: 2017-12-11T22:46:43Z [Term] id: GO:0120120 name: bilobe structure namespace: cellular_component def: "A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone)." [PMID:22327007, PMID:22445359, PMID:26540076] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. synonym: "kinetoplastid flagellar hook complex" EXACT [PMID:26540076] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton created_by: kchris creation_date: 2017-12-11T23:47:20Z [Term] id: GO:0120121 name: tripartite attachment complex namespace: cellular_component def: "A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body." [PMID:12802053, PMID:18059470, PMID:24821793, PMID:27168148] synonym: "TAC" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton created_by: kchris creation_date: 2017-12-12T00:07:37Z [Term] id: GO:0120122 name: prolactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals." [PMID:11015620] synonym: "prolactin metabolism" EXACT [] is_a: GO:0034754 ! cellular hormone metabolic process created_by: kchris creation_date: 2018-01-25T17:28:40Z [Term] id: GO:0120123 name: ubiquitin activating enzyme complex namespace: cellular_component def: "A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:lnp, PMID:9545234] synonym: "E1 complex" EXACT [GOC:lnp] synonym: "E1 ubiquitin-activating enzyme" RELATED [GOC:lnp] xref: IntAct:EBI-16629455 is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular created_by: kchris creation_date: 2018-01-29T19:28:56Z [Term] id: GO:0120124 name: membrane fusion priming complex namespace: cellular_component def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:90153011] synonym: "GATE-16 complex" EXACT [] synonym: "LMA1 complex" EXACT [] xref: IntAct:EBI-16411729 is_a: GO:0032991 ! protein-containing complex created_by: kchris creation_date: 2018-02-06T22:22:47Z [Term] id: GO:0120125 name: PNGase complex namespace: cellular_component def: "A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [GOC:lnp, PMID:15964983, PMID:16249333] xref: IntAct:EBI-16422385 is_a: GO:1905368 ! peptidase complex created_by: kchris creation_date: 2018-02-12T16:31:57Z [Term] id: GO:0120126 name: response to copper ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion." [GOC:sl, PMID:24024382] is_a: GO:0042594 ! response to starvation created_by: kchris creation_date: 2018-02-12T19:49:19Z [Term] id: GO:0120127 name: response to zinc ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion." [GOC:sl, PMID:24024381] is_a: GO:0042594 ! response to starvation created_by: kchris creation_date: 2018-02-12T19:57:02Z [Term] id: GO:0120132 name: positive regulation of apoptotic process in bone marrow cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27908889] synonym: "activation of apoptosis in bone marrow" NARROW [GOC:krc] synonym: "positive regulation of apoptosis in bone marrow" NARROW [GO:krc] synonym: "positive regulation of apoptotic process in bone marrow" EXACT [] synonym: "positive regulation of bone marrow cell apoptosis" EXACT [GOC:krc] synonym: "positive regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:krc] synonym: "positive regulation of killing of bone marrow cells" EXACT [GOC:krc] synonym: "positive regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:krc] synonym: "positive regulation of programmed cell death, bone marrow cells" EXACT [GOC:krc] synonym: "up regulation of apoptosis in bone marrow" EXACT [GOC:krc] synonym: "up-regulation of apoptosis in bone marrow" EXACT [GOC:krc] synonym: "upregulation of apoptosis in bone marrow" EXACT [GOC:krc] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071839 ! apoptotic process in bone marrow cell relationship: positively_regulates GO:0071839 ! apoptotic process in bone marrow cell created_by: kchris creation_date: 2018-02-19T16:51:46Z [Term] id: GO:0120133 name: negative regulation of actin cortical patch assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches." [PMID:19962315] synonym: "down regulation of actin cortical patch assembly" EXACT [] synonym: "down-regulation of actin cortical patch assembly" EXACT [] synonym: "downregulation of actin cortical patch assembly" EXACT [] synonym: "inhibition of actin cortical patch assembly" NARROW [] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000147 ! actin cortical patch assembly relationship: negatively_regulates GO:0000147 ! actin cortical patch assembly created_by: kchris creation_date: 2018-02-20T16:23:53Z [Term] id: GO:0120134 name: proximal portion of axoneme namespace: cellular_component def: "The portion of the axoneme that is close to the base of the cilium." [GOC:krc] synonym: "proximal part of axoneme" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005930 ! axoneme created_by: kchris creation_date: 2018-03-10T01:41:06Z [Term] id: GO:0120135 name: distal portion of axoneme namespace: cellular_component def: "The portion of the axoneme that is close to the tip of the cilium." [GOC:krc] synonym: "distal part of axoneme" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005930 ! axoneme created_by: kchris creation_date: 2018-03-10T01:45:34Z [Term] id: GO:0120136 name: dUMP kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dUMP = ADP + dUDP." [PMID:3010881] synonym: "ATP:dUMP phosphotransferase activity" EXACT [] synonym: "deoxyuridine monophosphate kinase activity" EXACT [] synonym: "dUMP-kinase activity" EXACT [] is_a: GO:0009041 ! uridylate kinase activity created_by: kchris creation_date: 2018-03-21T21:16:06Z [Term] id: GO:0120137 name: positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity namespace: biological_process def: "Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0062002 ! regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity relationship: positively_regulates GO:0052885 ! all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity created_by: kchris creation_date: 2018-03-21T21:59:55Z [Term] id: GO:0120138 name: regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity relationship: regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity created_by: kchris creation_date: 2018-03-22T16:15:08Z [Term] id: GO:0120139 name: positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0120138 ! regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity relationship: positively_regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity created_by: kchris creation_date: 2018-03-22T16:24:20Z [Term] id: GO:0120140 name: negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:0120138 ! regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity relationship: negatively_regulates GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity created_by: kchris creation_date: 2018-03-22T16:32:59Z [Term] id: GO:0120141 name: regulation of ecdysone receptor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway relationship: regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway created_by: kchris creation_date: 2018-03-22T17:10:29Z [Term] id: GO:0120142 name: positive regulation of ecdysone receptor-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:0120141 ! regulation of ecdysone receptor-mediated signaling pathway is_a: GO:1905959 ! positive regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway relationship: positively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway created_by: kchris creation_date: 2018-03-22T17:25:00Z [Term] id: GO:0120143 name: negative regulation of ecdysone receptor-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:0120141 ! regulation of ecdysone receptor-mediated signaling pathway is_a: GO:1905958 ! negative regulation of cellular response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway relationship: negatively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway created_by: kchris creation_date: 2018-03-22T17:28:29Z [Term] id: GO:0120145 name: protein localization to basal ectoplasmic specialization namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization." [PMID:22872576] synonym: "protein localisation in basal ectoplasmic specialization" EXACT [GOC:krc] synonym: "protein localisation to basal ectoplasmic specialization" EXACT [GOC:krc] synonym: "protein localization in basal ectoplasmic specialization" EXACT [GOC:krc] is_a: GO:0150105 ! protein localization to cell-cell junction created_by: kchris creation_date: 2018-03-27T20:16:09Z [Term] id: GO:0120146 name: sulfatide binding namespace: molecular_function def: "Interacting selectively and non-covalently with sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group." [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide] synonym: "3-O-sulfogalactosylceramide binding" EXACT [] synonym: "SM4 binding" EXACT [] synonym: "sulfated galactocerebroside binding" EXACT [] is_a: GO:0051861 ! glycolipid binding created_by: kchris creation_date: 2018-03-30T20:44:03Z [Term] id: GO:0120147 name: Formylglycine-generating oxidase activity namespace: molecular_function def: "Catalysis of the reaction: A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O." [EC:1.8.3.7, RHEA:51152] xref: EC:1.8.3.7 xref: MetaCyc:RXN-16226 xref: RHEA:51152 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor created_by: kchris creation_date: 2018-04-06T15:38:52Z [Term] id: GO:0120148 name: host cell centrosome namespace: cellular_component def: "A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [ISBN:0198547684] synonym: "host centrosome" EXACT [] is_a: GO:0044163 ! host cytoskeleton created_by: kchris creation_date: 2018-04-13T15:22:54Z [Term] id: GO:0120149 name: host cell peroxisome namespace: cellular_component def: "A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [PMID:9302272] synonym: "host peroxisome" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0033655 ! host cell cytoplasm part created_by: kchris creation_date: 2018-04-13T15:36:40Z [Term] id: GO:0120150 name: regulation of mitotic actomyosin contractile ring disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423] synonym: "regulation of mitotic actomyosin ring disassembly" EXACT [PMID:19109423] synonym: "regulation of mitotic CAR disassembly" EXACT [PMID:19109423] synonym: "regulation of mitotic constriction ring disassembly" EXACT [PMID:19109423] synonym: "regulation of mitotic contractile actomyosin ring disassembly" EXACT [PMID:19109423] synonym: "regulation of mitotic cytokinetic ring disassembly" EXACT [PMID:19109423] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly relationship: regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly created_by: kchris creation_date: 2018-04-24T15:06:28Z [Term] id: GO:0120151 name: positive regulation of mitotic actomyosin contractile ring disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423] synonym: "positive regulation of mitotic actomyosin ring disassembly" EXACT [PMID:19109423] synonym: "positive regulation of mitotic CAR disassembly" EXACT [PMID:19109423] synonym: "positive regulation of mitotic constriction ring disassembly" EXACT [PMID:19109423] synonym: "positive regulation of mitotic contractile actomyosin ring disassembly" EXACT [PMID:19109423] synonym: "positive regulation of mitotic cytokinetic ring disassembly" EXACT [PMID:19109423] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0120150 ! regulation of mitotic actomyosin contractile ring disassembly is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly relationship: positively_regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly created_by: kchris creation_date: 2018-04-24T15:06:51Z [Term] id: GO:0120152 name: calcium-dependent outer dynein arm binding namespace: molecular_function def: "Interacting selectively and non-covalently with an outer dynein arm in the presence of calcium." [GOC:krc, PMID:18620543] is_a: GO:0048306 ! calcium-dependent protein binding created_by: kchris creation_date: 2018-04-27T16:33:39Z [Term] id: GO:0120153 name: calcium-dependent carbohydrate binding namespace: molecular_function def: "Interacting selectively and non-covalently with any carbohydrate in the presence of calcium." [PMID:25912189] is_a: GO:0030246 ! carbohydrate binding created_by: kchris creation_date: 2018-04-27T16:42:21Z [Term] id: GO:0120154 name: negative regulation of ERBB4 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway." [PMID:15219672] is_a: GO:1901185 ! negative regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038130 ! ERBB4 signaling pathway relationship: negatively_regulates GO:0038130 ! ERBB4 signaling pathway created_by: kchris creation_date: 2018-05-01T17:12:23Z [Term] id: GO:0120155 name: MIH complex namespace: cellular_component def: "A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins." [GOC:rn, PMID:24413167, PMID:24895401] synonym: "Mlc1p-Iqg1p-Hof1p complex" EXACT [GOC:rn] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005935 ! cellular bud neck created_by: kchris creation_date: 2018-05-01T17:50:23Z [Term] id: GO:0120157 name: PAR polarity complex namespace: cellular_component def: "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC." [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236] comment: "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4. synonym: "apical polarity complex" EXACT [GOC:lnp] synonym: "BEM1-CDC24-CLA4 complex" NARROW [] synonym: "Cdc42p GEF-PAK complex" NARROW [] synonym: "PAR3-PAR6-atypical PKC" NARROW [GOC:lnp] synonym: "PAR3/PAR6/aPKC" NARROW [GOC:lnp] synonym: "PAR6-PAR3-aPKC complex" NARROW [PMID:18005931] xref: ComplexPortal:CPX-3462 is_a: GO:1902554 ! serine/threonine protein kinase complex created_by: kchris creation_date: 2018-05-11T15:41:30Z [Term] id: GO:0120158 name: positive regulation of collagen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010714 ! positive regulation of collagen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030574 ! collagen catabolic process relationship: positively_regulates GO:0030574 ! collagen catabolic process created_by: kchris creation_date: 2018-05-11T16:31:42Z [Term] id: GO:0120159 name: rRNA pseudouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181] synonym: "16S rRNA pseudouridine(516) synthase" NARROW [EC:5.4.99.19] synonym: "21S rRNA pseudouridine(2819) synthase" NARROW [EC:5.4.99.43] synonym: "23S rRNA pseudouridine(1911/1915/1917) synthase" NARROW [EC:5.4.99.23] synonym: "23S rRNA pseudouridine(2457) synthase" NARROW [EC:5.4.99.20] synonym: "23S rRNA pseudouridine(2604) synthase" NARROW [EC:5.4.99.21] synonym: "23S rRNA pseudouridine(2605) synthase" NARROW [EC:5.4.99.22] synonym: "23S rRNA pseudouridine(746) synthase" NARROW [EC:5.4.99.29] synonym: "23S rRNA pseudouridine(955/2504/2580) synthase" NARROW [EC:5.4.99.24] xref: EC:5.4.99.19 xref: EC:5.4.99.20 xref: EC:5.4.99.21 xref: EC:5.4.99.22 xref: EC:5.4.99.23 xref: EC:5.4.99.24 xref: EC:5.4.99.29 xref: EC:5.4.99.43 is_a: GO:0009982 ! pseudouridine synthase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: kchris creation_date: 2018-05-11T21:24:19Z [Term] id: GO:0120160 name: intraciliary transport particle A binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intraciliary transport particle A (IFT A) complex." [PMID:20889716] synonym: "IFT A complex binding" RELATED [] synonym: "intraciliary transport complex A binding" EXACT [] synonym: "intraflagellar transport complex A binding" EXACT [] synonym: "intraflagellar transport particle A binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2018-05-11T22:28:11Z [Term] id: GO:0120161 name: regulation of cold-induced thermogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809] synonym: "regulation of CIT" RELATED [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0106106 ! cold-induced thermogenesis relationship: regulates GO:0106106 ! cold-induced thermogenesis created_by: kchris creation_date: 2018-05-14T17:03:19Z [Term] id: GO:0120162 name: positive regulation of cold-induced thermogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809] synonym: "positive regulation of CIT" RELATED [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0120161 ! regulation of cold-induced thermogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0106106 ! cold-induced thermogenesis relationship: positively_regulates GO:0106106 ! cold-induced thermogenesis created_by: kchris creation_date: 2018-05-14T17:14:51Z [Term] id: GO:0120163 name: negative regulation of cold-induced thermogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis." [PMID:27876809] synonym: "negative regulation of CIT" RELATED [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0120161 ! regulation of cold-induced thermogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0106106 ! cold-induced thermogenesis relationship: negatively_regulates GO:0106106 ! cold-induced thermogenesis created_by: kchris creation_date: 2018-05-14T17:18:59Z [Term] id: GO:0120164 name: conidium germination namespace: biological_process def: "The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination." [DOI:10.1128/9781555815523.ch10, PMID:10835388, PMID:11377860, PMID:17950638, PMID:18944978, PMID:25063657, PMID:27355215, PMID:9529886] is_a: GO:0009847 ! spore germination created_by: kchris creation_date: 2018-05-17T17:03:32Z [Term] id: GO:0120165 name: perithecium development namespace: biological_process def: "The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:19547974, PMID:20739093, PMID:25311923] is_a: GO:0030582 ! reproductive fruiting body development created_by: kchris creation_date: 2018-05-17T17:17:44Z [Term] id: GO:0120166 name: protoperithecium formation namespace: biological_process def: "The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:20739093, PMID:25311923, PMID:4410944, PMID:6235211, PMID:6235212] comment: Note that this term represents protoperithecium formation across homothallic and heterothallic species that do not have the same mechanism. is_a: GO:0030582 ! reproductive fruiting body development created_by: kchris creation_date: 2018-05-17T17:27:16Z [Term] id: GO:0120168 name: detection of hot stimulus involved in thermoception namespace: biological_process def: "The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241] synonym: "sensory detection of heat stimulus during thermoception" EXACT [] synonym: "sensory detection of hot stimulus during thermoception" EXACT [] synonym: "sensory transduction of heat stimulus during thermoception" EXACT [] synonym: "sensory transduction of hot stimulus during thermoception" EXACT [] synonym: "thermoception, sensory detection of heat stimulus" EXACT [] synonym: "thermoception, sensory detection of hot stimulus" EXACT [] synonym: "thermoception, sensory transduction of heat stimulus" EXACT [] synonym: "thermoception, sensory transduction of hot stimulus" EXACT [] is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception relationship: part_of GO:0062036 ! sensory perception of hot stimulus created_by: kchris creation_date: 2018-05-21T20:35:47Z [Term] id: GO:0120169 name: detection of cold stimulus involved in thermoception namespace: biological_process def: "The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241] synonym: "sensory detection of cold stimulus during thermoception" EXACT [] synonym: "sensory transduction of cold stimulus during thermoception" EXACT [] synonym: "thermoception, sensory detection of cold stimulus" EXACT [] synonym: "thermoception, sensory transduction of cold stimulus" EXACT [] is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception relationship: part_of GO:0062035 ! sensory perception of cold stimulus created_by: kchris creation_date: 2018-05-21T20:36:05Z [Term] id: GO:0120170 name: intraciliary transport particle B binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intraciliary transport particle B (IFT B) complex." [PMID:20889716] synonym: "IFT B complex binding" RELATED [] synonym: "intraciliary transport complex B binding" EXACT [] synonym: "intraflagellar transport complex B binding" EXACT [] synonym: "intraflagellar transport particle B binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: kchris creation_date: 2018-05-11T22:28:11Z [Term] id: GO:0120171 name: Cdc24p-Far1p-Gbetagamma complex namespace: cellular_component def: "A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit)." [PMID:10087263] synonym: "CDC24-FAR1-BG complex" EXACT [GOC:bm] synonym: "CDC24-FAR1-Gbetagamma complex" EXACT [GOC:bm] synonym: "Cdc24p-Far1p-BG complex" EXACT [GOC:rn, PMID:10087263] xref: ComplexPortal:CPX-977 is_a: GO:0032991 ! protein-containing complex created_by: kchris creation_date: 2018-05-31T17:11:20Z [Term] id: GO:0120172 name: positive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735] is_a: GO:0120173 ! regulation of actin filament bundle convergence involved in mitotic contractile ring assembly is_a: GO:1903482 ! positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly relationship: positively_regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly created_by: kchris creation_date: 2018-05-31T17:54:35Z [Term] id: GO:0120173 name: regulation of actin filament bundle convergence involved in mitotic contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735] is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly relationship: regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly created_by: kchris creation_date: 2018-05-31T18:08:01Z [Term] id: GO:0120174 name: stress-induced homeostatically regulated protein degradation pathway namespace: biological_process def: "A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway." [GOC:rl, GOC:rn, PMID:29861160] comment: Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct. synonym: "SHRED pathway" RELATED [GOC:rn] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0033554 ! cellular response to stress is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: kchris creation_date: 2018-06-07T16:16:43Z [Term] id: GO:0120175 name: regulation of torso signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008293 ! torso signaling pathway relationship: regulates GO:0008293 ! torso signaling pathway created_by: kchris creation_date: 2018-06-07T16:47:42Z [Term] id: GO:0120176 name: positive regulation of torso signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0120175 ! regulation of torso signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008293 ! torso signaling pathway relationship: positively_regulates GO:0008293 ! torso signaling pathway created_by: kchris creation_date: 2018-06-07T16:52:52Z [Term] id: GO:0120177 name: negative regulation of torso signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0120175 ! regulation of torso signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008293 ! torso signaling pathway relationship: negatively_regulates GO:0008293 ! torso signaling pathway created_by: kchris creation_date: 2018-06-07T16:58:08Z [Term] id: GO:0120178 name: steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process created_by: kchris creation_date: 2019-05-20T22:34:00Z [Term] id: GO:0120179 name: adherens junction disassembly namespace: biological_process def: "The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, PMID:25490267] is_a: GO:0034332 ! adherens junction organization is_a: GO:0150147 ! cell-cell junction disassembly created_by: kchris creation_date: 2018-07-12T17:29:56Z [Term] id: GO:0120180 name: cell-substrate junction disassembly namespace: biological_process def: "The disaggregation of a cell-substrate junction into its constituent components." [GOC:aruk, GOC:bc, PMID:25490267] is_a: GO:0150115 ! cell-substrate junction organization is_a: GO:0150146 ! cell junction disassembly created_by: kchris creation_date: 2018-07-12T17:33:35Z [Term] id: GO:0120181 name: focal adhesion disassembly namespace: biological_process def: "The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity." [PMID:25490267] is_a: GO:0120180 ! cell-substrate junction disassembly created_by: kchris creation_date: 2018-07-12T17:37:14Z [Term] id: GO:0120182 name: regulation of focal adhesion disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267] is_a: GO:0150116 ! regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0120181 ! focal adhesion disassembly relationship: regulates GO:0120181 ! focal adhesion disassembly created_by: kchris creation_date: 2018-07-12T17:44:29Z [Term] id: GO:0120183 name: positive regulation of focal adhesion disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267] is_a: GO:0120182 ! regulation of focal adhesion disassembly is_a: GO:0150117 ! positive regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0120181 ! focal adhesion disassembly relationship: positively_regulates GO:0120181 ! focal adhesion disassembly created_by: kchris creation_date: 2018-07-12T18:27:19Z [Term] id: GO:0120184 name: negative regulation of focal adhesion disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components." [PMID:25490267] is_a: GO:0120182 ! regulation of focal adhesion disassembly is_a: GO:0150118 ! negative regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0120181 ! focal adhesion disassembly relationship: negatively_regulates GO:0120181 ! focal adhesion disassembly created_by: kchris creation_date: 2018-07-12T18:30:06Z [Term] id: GO:0120185 name: MBF transcription complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex." [PMID:9303312] synonym: "DSC1 transcription factor complex assembly" EXACT [] synonym: "MBF complex assembly" EXACT [] synonym: "Mlu1-box binding factor assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: kchris creation_date: 2018-07-13T23:21:43Z [Term] id: GO:0120186 name: negative regulation of protein localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071168 ! protein localization to chromatin relationship: negatively_regulates GO:0071168 ! protein localization to chromatin created_by: kchris creation_date: 2018-07-14T00:19:32Z [Term] id: GO:0120187 name: positive regulation of protein localization to chromatin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071168 ! protein localization to chromatin relationship: positively_regulates GO:0071168 ! protein localization to chromatin created_by: kchris creation_date: 2018-07-14T00:21:28Z [Term] id: GO:0120188 name: regulation of bile acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0044070 ! regulation of anion transport is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032782 ! bile acid secretion relationship: regulates GO:0032782 ! bile acid secretion created_by: kchris creation_date: 2018-07-16T22:28:58Z [Term] id: GO:0120189 name: positive regulation of bile acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion is_a: GO:1903793 ! positive regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032782 ! bile acid secretion relationship: positively_regulates GO:0032782 ! bile acid secretion created_by: kchris creation_date: 2018-07-16T22:36:17Z [Term] id: GO:0120190 name: negative regulation of bile acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion is_a: GO:1903792 ! negative regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032782 ! bile acid secretion relationship: negatively_regulates GO:0032782 ! bile acid secretion created_by: kchris creation_date: 2018-07-16T22:38:34Z [Term] id: GO:0120191 name: negative regulation of termination of RNA polymerase II transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription." [GOC:krc, GOC:vw, PMID:29899453] synonym: "down regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] synonym: "down regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] synonym: "down regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] synonym: "down regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] synonym: "down regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] synonym: "down regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] synonym: "down-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] synonym: "down-regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] synonym: "down-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] synonym: "down-regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] synonym: "down-regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] synonym: "down-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] synonym: "downregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] synonym: "downregulation of RNA polymerase II transcription termination" EXACT [GOC:krc] synonym: "downregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] synonym: "downregulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] synonym: "downregulation of transcription termination from Pol II promoter" EXACT [GOC:krc] synonym: "downregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] synonym: "negative regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] synonym: "negative regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] synonym: "negative regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] synonym: "negative regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] synonym: "negative regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] synonym: "repression of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:krc] synonym: "repression of RNA polymerase II transcription termination" NARROW [GOC:krc] synonym: "repression of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] synonym: "repression of termination of RNA polymerase II transcription" NARROW [GOC:krc] synonym: "repression of transcription termination from Pol II promoter" NARROW [GOC:krc] synonym: "repression of transcription termination from RNA polymerase II promoter" NARROW [GOC:krc] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006369 ! termination of RNA polymerase II transcription relationship: negatively_regulates GO:0006369 ! termination of RNA polymerase II transcription created_by: kchris creation_date: 2018-07-18T15:43:40Z [Term] id: GO:0120192 name: tight junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl] synonym: "occluding cell junction assembly" EXACT [GOC:rl] synonym: "occluding junction assembly" EXACT [GOC:rl] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0120193 ! tight junction organization created_by: kchris creation_date: 2018-08-14T22:48:05Z [Term] id: GO:0120193 name: tight junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl] synonym: "occluding cell junction organization" EXACT [GOC:rl] synonym: "occluding junction organization" EXACT [] is_a: GO:0045216 ! cell-cell junction organization created_by: kchris creation_date: 2018-08-14T23:05:40Z [Term] id: GO:0120194 name: regulation of anther dehiscence namespace: biological_process def: "Any process involved in the dehiscence of an anther to release the pollen grains contained within it." [GOC:lr, PMID:30911018] is_a: GO:0009909 ! regulation of flower development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009901 ! anther dehiscence relationship: regulates GO:0009901 ! anther dehiscence created_by: kchris creation_date: 2019-04-09T21:40:39Z [Term] id: GO:0120195 name: positive regulation of anther dehiscence namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anther dehiscence" [GOC:lr, PMID:30911018] is_a: GO:0009911 ! positive regulation of flower development is_a: GO:0120194 ! regulation of anther dehiscence intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009901 ! anther dehiscence relationship: positively_regulates GO:0009901 ! anther dehiscence created_by: kchris creation_date: 2019-04-09T21:58:31Z [Term] id: GO:0120196 name: negative regulation of anther dehiscence namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence." [GOC:lr, PMID:30911018] is_a: GO:0009910 ! negative regulation of flower development is_a: GO:0120194 ! regulation of anther dehiscence intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009901 ! anther dehiscence relationship: negatively_regulates GO:0009901 ! anther dehiscence created_by: kchris creation_date: 2019-04-09T22:03:16Z [Term] id: GO:0120197 name: mucociliary clearance namespace: biological_process def: "The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways." [GOC:krc, PMID:24119105, PMID:27864314] synonym: "MCC" RELATED [PMID:24119105, PMID:27864314] synonym: "MCT" RELATED [PMID:28289722] synonym: "mucociliary transport" EXACT [PMID:28289722] is_a: GO:0003016 ! respiratory system process is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement created_by: kchris creation_date: 2019-04-26T16:16:50Z [Term] id: GO:0120198 name: positive regulation of imaginal disc-derived wing size namespace: biological_process def: "Any process that increases the size of an imaginal disc-derived wing." [GOC:ha, PIMD:23485686] is_a: GO:0044719 ! regulation of imaginal disc-derived wing size created_by: kchris creation_date: 2019-04-30T21:47:06Z [Term] id: GO:0120199 name: cone photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0001750 ! photoreceptor outer segment created_by: kchris creation_date: 2019-05-07T22:23:28Z [Term] id: GO:0120200 name: rod photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0001750 ! photoreceptor outer segment created_by: kchris creation_date: 2019-05-07T22:47:20Z [Term] id: GO:0120201 name: cone photoreceptor disc membrane namespace: cellular_component def: "Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0060170 ! ciliary membrane is_a: GO:0097381 ! photoreceptor disc membrane created_by: kchris creation_date: 2019-05-07T23:17:43Z [Term] id: GO:0120202 name: rod photoreceptor disc membrane namespace: cellular_component def: "Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0097381 ! photoreceptor disc membrane created_by: kchris creation_date: 2019-05-07T23:27:06Z [Term] id: GO:0120203 name: rod photoreceptor disc lumen namespace: cellular_component def: "The volume enclosed by the membrane of a rod photoreceptor cell disc membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] is_a: GO:0043233 ! organelle lumen relationship: part_of GO:0120200 ! rod photoreceptor outer segment created_by: kchris creation_date: 2019-05-07T23:49:50Z [Term] id: GO:0120204 name: methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2." [PMID:31043749] xref: RHEA:60132 xref: RHEA:60136 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen created_by: kchris creation_date: 2019-05-10T15:58:47Z [Term] id: GO:0120205 name: photoreceptor proximal connecting cilium namespace: cellular_component def: "The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR." [GOC:krc, PMID:29899041] synonym: "PCC" RELATED [PMID:29899041] synonym: "photoreceptor PCC" RELATED [PMID:29899041] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032391 ! photoreceptor connecting cilium created_by: kchris creation_date: 2019-05-10T22:47:08Z [Term] id: GO:0120206 name: photoreceptor distal connecting cilium namespace: cellular_component def: "The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability." [GOC:krc, PMID:29899041] synonym: "DCC" RELATED [PMID:29899041] synonym: "photoreceptor DCC" RELATED [PMID:29899041] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0032391 ! photoreceptor connecting cilium created_by: kchris creation_date: 2019-05-10T22:54:05Z [Term] id: GO:0120207 name: endocytosis, site selection namespace: biological_process def: "The process of selecting and or marking the position where endocytosis will occur." [GOC:vw, PMID:30044717] is_a: GO:1990778 ! protein localization to cell periphery relationship: part_of GO:0006897 ! endocytosis created_by: kchris creation_date: 2019-05-15T21:25:49Z [Term] id: GO:0120208 name: telodendria namespace: cellular_component def: "Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons." [GOC:cvs, GOC:krc, PMID:11074451, PMID:11506430, PMID:14755521, PMID:1646866, PMID:20533354, PMID:29127712, PMID:451992, PMID:8390352] is_a: GO:0043005 ! neuron projection created_by: kchris creation_date: 2019-05-20T23:50:28Z [Term] id: GO:0120209 name: cone teleodendria namespace: cellular_component def: "Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:29127712] is_a: GO:0120208 ! telodendria created_by: kchris creation_date: 2019-05-21T00:01:34Z [Term] id: GO:0120210 name: rod teleodendria namespace: cellular_component def: "Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:14755521] is_a: GO:0120208 ! telodendria created_by: kchris creation_date: 2019-05-21T00:34:22Z [Term] id: GO:0120211 name: proacrosomal vesicle fusion namespace: biological_process def: "Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome." [GOC:krc, PMID:29991750] is_a: GO:0006906 ! vesicle fusion is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0001675 ! acrosome assembly created_by: kchris creation_date: 2019-05-22T17:12:55Z [Term] id: GO:0120212 name: sperm head-tail coupling apparatus namespace: cellular_component def: "A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head." [GOC:krc, PMID:24415959, PMID:30032984] synonym: "head-tail coupling apparatus" EXACT [PMID:24415959, PMID:30032984] synonym: "HTCA" RELATED [PMID:24415959] is_a: GO:0110165 ! cellular anatomical entity created_by: kchris creation_date: 2019-06-07T23:08:46Z [Term] id: GO:0120213 name: regulation of histidine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "regulation of histidine anabolism" EXACT [GOC:krc] synonym: "regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "regulation of histidine formation" EXACT [GOC:krc] synonym: "regulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000105 ! histidine biosynthetic process relationship: regulates GO:0000105 ! histidine biosynthetic process created_by: kchris creation_date: 2019-06-27T20:55:42Z [Term] id: GO:0120214 name: negative regulation of histidine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "down regulation of histidine anabolism" EXACT [GOC:krc] synonym: "down regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "down regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "down regulation of histidine formation" EXACT [GOC:krc] synonym: "down regulation of histidine synthesis" EXACT [GOC:krc] synonym: "down-regulation of histidine anabolism" EXACT [GOC:krc] synonym: "down-regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "down-regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "down-regulation of histidine formation" EXACT [GOC:krc] synonym: "down-regulation of histidine synthesis" EXACT [GOC:krc] synonym: "downregulation of histidine anabolism" EXACT [GOC:krc] synonym: "downregulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "downregulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "downregulation of histidine formation" EXACT [GOC:krc] synonym: "downregulation of histidine synthesis" EXACT [GOC:krc] synonym: "inhibition of histidine anabolism" NARROW [GOC:krc] synonym: "inhibition of histidine biosynthesis" NARROW [GOC:krc] synonym: "inhibition of histidine biosynthetic process" NARROW [GOC:krc] synonym: "inhibition of histidine formation" NARROW [GOC:krc] synonym: "inhibition of histidine synthesis" NARROW [GOC:krc] synonym: "negative regulation of histidine anabolism" EXACT [GOC:krc] synonym: "negative regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "negative regulation of histidine formation" EXACT [GOC:krc] synonym: "negative regulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:0120213 ! regulation of histidine biosynthetic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000105 ! histidine biosynthetic process relationship: negatively_regulates GO:0000105 ! histidine biosynthetic process created_by: krc creation_date: 2019-06-27T20:56:35Z [Term] id: GO:0120215 name: positive regulation of histidine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] synonym: "activation of histidine anabolism" NARROW [GOC:krc] synonym: "activation of histidine biosynthesis" NARROW [GOC:krc] synonym: "activation of histidine biosynthetic process" NARROW [GOC:krc] synonym: "activation of histidine formation" NARROW [GOC:krc] synonym: "activation of histidine synthesis" NARROW [GOC:krc] synonym: "positive regulation of histidine anabolism" EXACT [GOC:krc] synonym: "positive regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "positive regulation of histidine formation" EXACT [GOC:krc] synonym: "positive regulation of histidine synthesis" EXACT [GOC:krc] synonym: "up regulation of histidine anabolism" EXACT [GOC:krc] synonym: "up regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "up regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "up regulation of histidine formation" EXACT [GOC:krc] synonym: "up regulation of histidine synthesis" EXACT [GOC:krc] synonym: "up-regulation of histidine anabolism" EXACT [GOC:krc] synonym: "up-regulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "up-regulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "up-regulation of histidine formation" EXACT [GOC:krc] synonym: "up-regulation of histidine synthesis" EXACT [GOC:krc] synonym: "upregulation of histidine anabolism" EXACT [GOC:krc] synonym: "upregulation of histidine biosynthesis" EXACT [GOC:krc] synonym: "upregulation of histidine biosynthetic process" EXACT [GOC:krc] synonym: "upregulation of histidine formation" EXACT [GOC:krc] synonym: "upregulation of histidine synthesis" EXACT [GOC:krc] is_a: GO:0120213 ! regulation of histidine biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000105 ! histidine biosynthetic process relationship: positively_regulates GO:0000105 ! histidine biosynthetic process created_by: krc creation_date: 2019-06-27T20:57:28Z [Term] id: GO:0120216 name: matrilin complex namespace: cellular_component def: "A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer." [GOC:bhm, PMID:10367731, PMID:15075323, PMID:9699631] synonym: "matrilin family complex" RELATED [GOC:bhm] synonym: "matrilin-1 complex" NARROW [GOC:bhm] synonym: "matrilin-2 complex" NARROW [GOC:bhm] synonym: "matrilin-3 complex" NARROW [GOC:bhm] synonym: "matrilin-4 complex" NARROW [GOC:bhm] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: kchris creation_date: 2019-07-09T22:05:11Z [Term] id: GO:0120217 name: DNA gyrase complex namespace: cellular_component def: "A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB)." [GOC:bhm, GOC:krc, PMID:1657531, PMID:20675723, Wikipedia:DNA_gyrase] synonym: "topoisomerase II complex" EXACT [GOC:bhm, GOC:krc, Wikipedia:DNA_gyrase] is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex relationship: part_of GO:0005737 ! cytoplasm created_by: kchris creation_date: 2019-08-20T18:36:35Z [Term] id: GO:0120218 name: host interaction involved in quorum sensing namespace: biological_process def: "A quorum sensing process that is modulated by some interaction with a host cell or organism." [GOC:krc, GOC:mlg, PMID:11780122, PMID:16630813] is_a: GO:0009372 ! quorum sensing created_by: kchris creation_date: 2019-11-01T21:52:08Z [Term] id: GO:0120219 name: subapical part of cell namespace: cellular_component def: "The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina." [GOC:krc, PMID:29891944] synonym: "subapical region of cell" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical entity created_by: kchris creation_date: 2019-11-15T17:08:22Z [Term] id: GO:0120220 name: basal body patch namespace: cellular_component def: "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster." [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944] synonym: "centriolar patch" EXACT [GOC:krc, PMID:29891944] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045177 ! apical part of cell created_by: kchris creation_date: 2019-11-15T17:19:24Z [Term] id: GO:0120221 name: maintenance of ciliary planar beating movement pattern namespace: biological_process def: "Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement." [GOC:krc, PMID:26506310] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0003352 ! regulation of cilium movement created_by: kchris creation_date: 2019-12-10T21:34:54Z [Term] id: GO:0140007 name: KICSTOR complex namespace: cellular_component def: "A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2." [PMID:28199306] is_a: GO:0032991 ! protein-containing complex created_by: pg creation_date: 2017-03-10T12:47:30Z [Term] id: GO:0140009 name: L-aspartate import across plasma membrane namespace: biological_process def: "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000069, PMID:7914198] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0070778 ! L-aspartate transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane created_by: pg creation_date: 2017-03-13T10:59:51Z [Term] id: GO:0140010 name: D-aspartate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-aspartate from one side of a membrane to the other." [GO_REF:0000070, PMID:7914198] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity is_a: GO:0042943 ! D-amino acid transmembrane transporter activity relationship: part_of GO:0070777 ! D-aspartate transport created_by: pg creation_date: 2017-03-13T11:15:15Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: pg creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140018 name: regulation of cytoplasmic translational fidelity namespace: biological_process def: "Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code." [PMID:22768388] is_a: GO:0006450 ! regulation of translational fidelity is_a: GO:1900247 ! regulation of cytoplasmic translational elongation created_by: pg creation_date: 2017-04-06T12:27:10Z [Term] id: GO:0140020 name: DNA methyltransferase complex namespace: cellular_component def: "A protein complex that possesses DNA methyltransferase activity." [PMID:20939822, PMID:24947342] is_a: GO:0034708 ! methyltransferase complex created_by: pg creation_date: 2017-04-06T19:12:09Z [Term] id: GO:0140021 name: mitochondrial ADP transmembrane transport namespace: biological_process def: "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:2541251] is_a: GO:0015866 ! ADP transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: pg creation_date: 2017-04-10T15:14:34Z [Term] id: GO:0140022 name: cnida namespace: cellular_component def: "A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria." [http://en.wikipedia.org/wiki/Cnida#Structure_and_function] synonym: "cnidae (plural)" EXACT [] is_a: GO:0110165 ! cellular anatomical entity created_by: cjm creation_date: 2017-04-12T15:12:20Z [Term] id: GO:0140023 name: tRNA adenosine deamination to inosine namespace: biological_process def: "The removal of an amine group from an adenosine to produce inosine within a tRNA molecule." [PMID:27974624] synonym: "A-to-I tRNA editing" EXACT [] is_a: GO:0006400 ! tRNA modification created_by: pg creation_date: 2017-04-26T05:56:51Z [Term] id: GO:0140024 name: plus-end-directed endosome transport along mitotic spindle midzone microtubule namespace: biological_process def: "The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination." [PMID:24803650, PMID:25706234] is_a: GO:0072383 ! plus-end-directed vesicle transport along microtubule created_by: pg creation_date: 2017-04-29T11:34:23Z [Term] id: GO:0140025 name: contractile vacuole tethering involved in discharge namespace: biological_process def: "The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [PMID:22323285] synonym: "contractile vacuole tethering to plasma membrane" NARROW [] is_a: GO:0006903 ! vesicle targeting is_a: GO:0090522 ! vesicle tethering involved in exocytosis intersection_of: GO:0006903 ! vesicle targeting intersection_of: part_of GO:0070177 ! contractile vacuole discharge relationship: part_of GO:0070177 ! contractile vacuole discharge created_by: pg creation_date: 2017-05-02T09:50:10Z [Term] id: GO:0140026 name: contractile vacuole dissociation from plasma membrane namespace: biological_process def: "The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network." [PMID:22323285] synonym: "contractile vacuole detethering from plasma membrane" EXACT [] is_a: GO:0016192 ! vesicle-mediated transport created_by: pg creation_date: 2017-05-02T10:16:12Z [Term] id: GO:0140027 name: establishment of contractile vacuole localization namespace: biological_process def: "The directed movement of the contractile vacuole to a specific location." [PMID:19687255] is_a: GO:0051656 ! establishment of organelle localization created_by: pg creation_date: 2017-05-02T10:23:26Z [Term] id: GO:0140028 name: pore formation during contractile vacuole discharge namespace: biological_process def: "The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes." [PMID:22323285, Wikipedia:Exocytosis] is_a: GO:0140029 ! exocytic process relationship: part_of GO:0070177 ! contractile vacuole discharge created_by: pg creation_date: 2017-05-15T12:20:27Z [Term] id: GO:0140029 name: exocytic process namespace: biological_process def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0006887 ! exocytosis relationship: part_of GO:0006887 ! exocytosis created_by: pg creation_date: 2017-05-15T13:20:45Z [Term] id: GO:0140030 name: modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon post-translation modification of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. synonym: "modified protein binding" RELATED [] is_a: GO:0005515 ! protein binding created_by: pg creation_date: 2017-05-17T11:50:41Z [Term] id: GO:0140031 name: phosphorylation-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon phosphorylation of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of the protein to another region; this type of phosphorylation-dependent protein binding is valid for annotation to this term. is_a: GO:0140030 ! modification-dependent protein binding created_by: pg creation_date: 2017-05-17T15:15:19Z [Term] id: GO:0140032 name: glycosylation-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon glycosylation of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the protein to another region; this type of glycosylation-dependent protein binding is valid for annotation to this term. is_a: GO:0140030 ! modification-dependent protein binding created_by: pg creation_date: 2017-05-17T15:20:50Z [Term] id: GO:0140033 name: acetylation-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon acetylation of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term. is_a: GO:0140030 ! modification-dependent protein binding created_by: pg creation_date: 2017-05-17T15:35:43Z [Term] id: GO:0140034 name: methylation-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon methylation of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein to another region; this type of methylation-dependent protein binding is valid for annotation to this term. is_a: GO:0140030 ! modification-dependent protein binding created_by: pg creation_date: 2017-05-17T15:40:02Z [Term] id: GO:0140035 name: ubiquitination-like modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon modification by a ubiquitin-like protein of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. is_a: GO:0140030 ! modification-dependent protein binding created_by: pg creation_date: 2017-05-18T06:11:27Z [Term] id: GO:0140036 name: ubiquitin-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon ubiquitination of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the protein to another region; this type of ubiquitination-dependent protein binding is valid for annotation to this term. is_a: GO:0140035 ! ubiquitination-like modification-dependent protein binding created_by: pg creation_date: 2017-05-18T06:29:14Z [Term] id: GO:0140037 name: sumo-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon sumoylation of the target protein." [PMID:26060076] comment: This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein to another region; this type of sumoylation-dependent protein binding is valid for annotation to this term. is_a: GO:0140035 ! ubiquitination-like modification-dependent protein binding created_by: pg creation_date: 2017-05-18T06:29:27Z [Term] id: GO:0140039 name: cell-cell adhesion in response to extracellular stimulus namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031668 ! cellular response to extracellular stimulus created_by: pg creation_date: 2017-05-24T11:37:30Z [Term] id: GO:0140040 name: mitochondrial polycistronic RNA processing namespace: biological_process def: "The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs." [PMID:20211597] is_a: GO:0031426 ! polycistronic mRNA processing is_a: GO:0090615 ! mitochondrial mRNA processing intersection_of: GO:0031426 ! polycistronic mRNA processing intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: pg creation_date: 2017-06-16T07:18:38Z [Term] id: GO:0140041 name: cellular detoxification of methylglyoxal namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal." [PMID:15042280] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0098754 ! detoxification relationship: occurs_in GO:0005623 ! cell relationship: part_of GO:0097238 ! cellular response to methylglyoxal created_by: pg creation_date: 2017-06-16T09:43:30Z [Term] id: GO:0140042 name: lipid droplet formation namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631] synonym: "adiposome formation" EXACT [] synonym: "lipid body formation" EXACT [] synonym: "lipid particle formation" EXACT [] is_a: GO:0034389 ! lipid droplet organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0019915 ! lipid storage created_by: pg creation_date: 2017-06-19T09:18:43Z [Term] id: GO:0140043 name: lipid droplet localization to prospore membrane leading edge namespace: biological_process def: "Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge." [PMID:28011631] synonym: "adiposome localization to ascospore-type prospore membrane leading edge" EXACT [] synonym: "adiposome localization to forespore membrane leading edge" RELATED [] synonym: "adiposome localization to FSM membrane leading edge" EXACT [] synonym: "lipid body localization to ascospore-type prospore membrane leading edge" EXACT [] synonym: "lipid body localization to forespore membrane leading edge" RELATED [] synonym: "lipid body localization to FSM membrane leading edge" EXACT [] synonym: "lipid particle localization to ascospore-type prospore membrane leading edge" EXACT [] synonym: "lipid particle localization to forespore membrane leading edge" RELATED [] synonym: "lipid particle localization to FSM membrane leading edge" EXACT [] is_a: GO:0010876 ! lipid localization created_by: pg creation_date: 2017-06-19T09:20:13Z [Term] id: GO:0140048 name: manganese ion export across plasma membrane namespace: biological_process def: "The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:25319704] synonym: "manganese ion export from cell" EXACT [] is_a: GO:0071421 ! manganese ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: pg creation_date: 2017-06-23T14:25:00Z [Term] id: GO:0140049 name: regulation of endocardial cushion to mesenchymal transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090500 ! endocardial cushion to mesenchymal transition relationship: regulates GO:0090500 ! endocardial cushion to mesenchymal transition created_by: pg creation_date: 2017-06-23T15:57:00Z [Term] id: GO:0140050 name: negative regulation of endocardial cushion to mesenchymal transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition relationship: negatively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition created_by: pg creation_date: 2017-06-26T09:02:27Z [Term] id: GO:0140051 name: positive regulation of endocardial cushion to mesenchymal transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition relationship: positively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition created_by: pg creation_date: 2017-06-26T09:11:03Z [Term] id: GO:0140052 name: cellular response to oxidised low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus." [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416] synonym: "cellular response to ox-LDL particle stimulus" EXACT [] synonym: "cellular response to oxidised LDL particle stimulus" EXACT [] synonym: "cellular response to oxidized LDL particle stimulus" EXACT [] synonym: "cellular response to oxidized low-density lipoprotein particle stimulus" EXACT [] synonym: "cellular response to oxLDL particle stimulus" EXACT [] is_a: GO:0055094 ! response to lipoprotein particle is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus created_by: pg creation_date: 2017-06-26T09:40:00Z [Term] id: GO:0140053 name: mitochondrial gene expression namespace: biological_process def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] subset: goslim_pombe is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: pg creation_date: 2017-06-26T10:57:45Z [Term] id: GO:0140056 name: organelle localization by membrane tethering namespace: biological_process def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] subset: goslim_pombe is_a: GO:0022406 ! membrane docking is_a: GO:0051640 ! organelle localization created_by: pg creation_date: 2017-06-27T09:58:51Z [Term] id: GO:0140057 name: vacuole-mitochondria membrane tethering namespace: biological_process def: "The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:27875684] is_a: GO:0140056 ! organelle localization by membrane tethering created_by: pg creation_date: 2017-06-27T10:31:12Z [Term] id: GO:0140058 name: neuron projection arborization namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:aruk, GOC:bc, PMID:17114044, PMID:23270857, PMID:23764288] synonym: "branching morphogenesis of a neurite" RELATED [] synonym: "branching morphogenesis of a neuron projection" RELATED [] synonym: "neurite arborization" EXACT [] synonym: "neurite branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044] synonym: "neuron projection branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044] is_a: GO:0048812 ! neuron projection morphogenesis created_by: pg creation_date: 2017-07-12T12:25:31Z [Term] id: GO:0140059 name: dendrite arborization namespace: biological_process def: "The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:23270857] is_a: GO:0048813 ! dendrite morphogenesis is_a: GO:0140058 ! neuron projection arborization created_by: pg creation_date: 2017-07-12T15:12:07Z [Term] id: GO:0140060 name: axon arborization namespace: biological_process def: "The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches." [GOC:aruk, GOC:bc, PMID:23764288] is_a: GO:0007409 ! axonogenesis is_a: GO:0140058 ! neuron projection arborization created_by: pg creation_date: 2017-07-12T15:17:22Z [Term] id: GO:0140061 name: 5-hydroxymethylcytosine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2." [PMID:27918559] synonym: "5hmC dioxygenase" EXACT [] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity created_by: pg creation_date: 2017-07-20T09:54:50Z [Term] id: GO:0140062 name: 5-formylcytosine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2." [PMID:27918559] synonym: "5fC dioxygenase" EXACT [] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity created_by: pg creation_date: 2017-07-20T09:57:16Z [Term] id: GO:0140064 name: peptide crotonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide." [PMID:25818647] synonym: "protein crotonyltransferase activity" RELATED [] is_a: GO:0016410 ! N-acyltransferase activity created_by: pg creation_date: 2017-07-20T16:40:57Z [Term] id: GO:0140065 name: peptide butyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide." [PMID:27105113] synonym: "protein butyryltransferase activity" RELATED [] is_a: GO:0016410 ! N-acyltransferase activity created_by: pg creation_date: 2017-07-20T16:46:49Z [Term] id: GO:0140066 name: peptidyl-lysine crotonylation namespace: biological_process def: "The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid." [PMID:25818647, Wikipedia:crotonyl] is_a: GO:0043543 ! protein acylation created_by: pg creation_date: 2017-07-20T16:48:58Z [Term] id: GO:0140067 name: peptidyl-lysine butyrylation namespace: biological_process def: "The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid." [PMID:27105113, Wikipedia:butyryl] is_a: GO:0043543 ! protein acylation created_by: pg creation_date: 2017-07-20T16:52:19Z [Term] id: GO:0140068 name: histone crotonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone." [PMID:25818647] is_a: GO:0140064 ! peptide crotonyltransferase activity created_by: pg creation_date: 2017-07-20T16:55:16Z [Term] id: GO:0140069 name: histone butyryltransferase activity namespace: molecular_function def: "Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone." [PMID:27105113] is_a: GO:0140065 ! peptide butyryltransferase activity created_by: pg creation_date: 2017-07-20T16:56:33Z [Term] id: GO:0140074 name: cardiac endothelial to mesenchymal transition namespace: biological_process def: "A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes." [GOC:BHF, GOC:nc, PMID:16162442, PMID:26053665] synonym: "EndMT" EXACT [PMID:28181491] synonym: "EndoMT" EXACT [] is_a: GO:0048762 ! mesenchymal cell differentiation created_by: pg creation_date: 2017-07-21T09:39:49Z [Term] id: GO:0140075 name: regulation of lipoprotein transport namespace: biological_process def: "Any process that controls lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042953 ! lipoprotein transport relationship: regulates GO:0042953 ! lipoprotein transport created_by: pg creation_date: 2017-07-21T15:35:47Z [Term] id: GO:0140076 name: negative regulation of lipoprotein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:0140075 ! regulation of lipoprotein transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042953 ! lipoprotein transport relationship: negatively_regulates GO:0042953 ! lipoprotein transport created_by: pg creation_date: 2017-07-21T15:39:50Z [Term] id: GO:0140077 name: positive regulation of lipoprotein transport namespace: biological_process def: "Any process that activates or increases the rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:0140075 ! regulation of lipoprotein transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042953 ! lipoprotein transport relationship: positively_regulates GO:0042953 ! lipoprotein transport created_by: pg creation_date: 2017-07-21T15:41:54Z [Term] id: GO:0140078 name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, Wikipedia:AP_endonuclease] synonym: "AP endonuclease class I activity" RELATED [] synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [] synonym: "class I DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [] synonym: "DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] xref: EC:4.2.99.18 xref: MetaCyc:4.2.99.18-RXN is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity is_a: GO:0016835 ! carbon-oxygen lyase activity created_by: pg creation_date: 2017-07-24T11:33:34Z [Term] id: GO:0140080 name: class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH." [PMID:2519777, Wikipedia:AP_endonuclease] synonym: "endonuclease III" RELATED [] synonym: "endonuclease IV" RELATED [] is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters created_by: pg creation_date: 2017-07-24T11:48:18Z [Term] id: GO:0140081 name: glycosylated region protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycosylated region of a protein." [GOC:pg] is_a: GO:0005515 ! protein binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: pg creation_date: 2017-07-25T10:58:31Z [Term] id: GO:0140082 name: SUMO-ubiquitin ligase activity namespace: molecular_function def: "Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [PMID:28552615] is_a: GO:0061665 ! SUMO ligase activity created_by: pg creation_date: 2017-08-08T14:46:50Z [Term] id: GO:0140083 name: protein-DNA unloading ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate , this reaction drives the unwinding of the DNA helix and drives the removal of a protein or protein complex from a DNA molecule, by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction." [PMID:28552615] is_a: GO:0042623 ! ATPase activity, coupled created_by: pg creation_date: 2017-08-08T14:50:27Z [Term] id: GO:0140084 name: sexual macrocyst formation namespace: biological_process def: "The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum." [PMID:16592095, PMID:20089169] synonym: "macrocyst formation" RELATED [] synonym: "sexual fusion" RELATED [] is_a: GO:0019953 ! sexual reproduction created_by: pg creation_date: 2017-08-14T20:11:03Z [Term] id: GO:0140090 name: membrane curvature sensor activity namespace: molecular_function def: "Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins." [PMID:25898166] is_a: GO:0008289 ! lipid binding created_by: pg creation_date: 2017-08-19T20:37:54Z [Term] id: GO:0140091 name: mBAF complex namespace: cellular_component def: "A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof." [GO:bhm, PMID:11175787, PMID:12620226, PMID:15525990, PMID:8804307, PMID:8895581] synonym: "muscle-specific BAF complex" EXACT [] synonym: "muscle-specific SWI/SNF complex" EXACT [] synonym: "muscle-type BAF complex" EXACT [] synonym: "muscle-type SWI/SNF complex" EXACT [] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: pg creation_date: 2017-09-05T09:20:45Z [Term] id: GO:0140092 name: bBAF complex namespace: cellular_component def: "A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180." [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581] synonym: "brain-specific BAF complex" EXACT [] synonym: "brain-specific SWI/SNF complex" EXACT [] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: pg creation_date: 2017-09-05T09:22:41Z [Term] id: GO:0140093 name: esBAF complex namespace: cellular_component def: "An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C." [GOC:bhm, PMID:19279218, PMID:19279220, PMID:2620226, PMID:8804307, PMID:8895581] synonym: "embryonic stem cell-specific BAF complex" EXACT [] synonym: "embryonic stem cell-specific SWI/SNF complex" EXACT [] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: pg creation_date: 2017-09-05T09:23:51Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:pdt] comment: https://github.com/geneontology/go-ontology/issues/14225 is_a: GO:0003824 ! catalytic activity created_by: pg creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140097 name: catalytic activity, acting on DNA namespace: molecular_function def: "Catalytic activity that acts to modify DNA." [GOC:pdt] comment: https://github.com/geneontology/go-ontology/issues/14225 is_a: GO:0003824 ! catalytic activity created_by: pg creation_date: 2017-09-14T12:03:51Z [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA." [GOC:pdt] comment: https://github.com/geneontology/go-ontology/issues/14225 is_a: GO:0003824 ! catalytic activity created_by: pg creation_date: 2017-09-14T12:05:21Z [Term] id: GO:0140101 name: catalytic activity, acting on a tRNA namespace: molecular_function def: "Catalytic activity that acts to modify a tRNA." [GOC:pg] is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: pg creation_date: 2017-09-15T18:41:41Z [Term] id: GO:0140102 name: catalytic activity, acting on a rRNA namespace: molecular_function def: "Catalytic activity that acts to modify a ribosomal RNA." [GOC:pg] is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: pg creation_date: 2017-09-15T19:00:57Z [Term] id: GO:0140103 name: catalytic activity, acting on a glycoprotein namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:pg] is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: pg creation_date: 2017-09-15T19:27:54Z [Term] id: GO:0140104 name: molecular carrier activity namespace: molecular_function def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:pdt] comment: https://github.com/geneontology/go-ontology/issues/14221 subset: gocheck_do_not_annotate is_a: GO:0003674 ! molecular_function relationship: has_part GO:0051536 ! iron-sulfur cluster binding created_by: pg creation_date: 2017-09-19T13:10:18Z [Term] id: GO:0140105 name: interleukin-10-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of interleukin-10 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:11244051] synonym: "IL-10-mediated signaling pathway" EXACT [] synonym: "interleukin-10-mediated signalling pathway" EXACT [] is_a: GO:0019221 ! cytokine-mediated signaling pathway created_by: pg creation_date: 2017-09-22T16:04:42Z [Term] id: GO:0140107 name: high-affinity potassium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:10629185] is_a: GO:0015079 ! potassium ion transmembrane transporter activity created_by: pg creation_date: 2017-10-12T09:54:39Z [Term] id: GO:0140108 name: high-affinity glucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:25411338] comment: Requested in https://github.com/geneontology/go-ontology/issues/14212 is_a: GO:0005355 ! glucose transmembrane transporter activity created_by: pg creation_date: 2017-10-12T10:06:19Z [Term] id: GO:0140110 name: transcription regulator activity namespace: molecular_function def: "A molecular function that controls the rate, timing and/or magnitude of transcription of genetic information. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] comment: https://github.com/geneontology/go-ontology/issues/13588 subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon subset: goslim_plant is_a: GO:0003674 ! molecular_function created_by: pg creation_date: 2017-10-18T07:05:44Z [Term] id: GO:0140111 name: [choline trimethylamine-lyase]-activating enzyme activity namespace: molecular_function def: "Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [PMID:24854437] comment: Term request: https://github.com/geneontology/go-ontology/issues/14190 xref: MetaCyc:RXN-16470 is_a: GO:0043364 ! glycyl-radical enzyme activating activity created_by: pg creation_date: 2017-10-20T13:57:38Z [Term] id: GO:0140112 name: extracellular vesicle biogenesis namespace: biological_process def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] comment: Term request https://github.com/geneontology/go-ontology/issues/14256 synonym: "extracellular vesicle assembly" EXACT [] is_a: GO:0044085 ! cellular component biogenesis created_by: pg creation_date: 2017-10-23T11:53:42Z [Term] id: GO:0140113 name: extracellular microvesicle biogenesis namespace: biological_process def: "The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding." [PMID:28736435] comment: Term request https://github.com/geneontology/go-ontology/issues/14256 synonym: "extracellular microvesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis created_by: pg creation_date: 2017-10-23T12:00:11Z [Term] id: GO:0140114 name: cellular detoxification of fluoride namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] comment: Term request: https://github.com/geneontology/go-ontology/issues/14391 is_a: GO:1990748 ! cellular detoxification relationship: part_of GO:1902618 ! cellular response to fluoride created_by: pg creation_date: 2017-10-23T15:39:43Z [Term] id: GO:0140115 name: export across plasma membrane namespace: biological_process def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0140352 ! export from cell created_by: pg creation_date: 2017-10-24T14:38:16Z [Term] id: GO:0140116 name: fluoride export across plasma membrane namespace: biological_process def: "The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:27327046] is_a: GO:0140115 ! export across plasma membrane is_a: GO:1903424 ! fluoride transmembrane transport created_by: pg creation_date: 2017-10-24T14:51:01Z [Term] id: GO:0140121 name: Lewy body formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Lewy body." [PMID:15158159] comment: Term request https://github.com/geneontology/go-ontology/issues/14160 is_a: GO:0070841 ! inclusion body assembly created_by: pg creation_date: 2017-10-25T06:59:12Z [Term] id: GO:0140122 name: regulation of Lewy body formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Lewy body formation." [GOC:sl] comment: Term request https://github.com/geneontology/go-ontology/issues/14160 is_a: GO:0090083 ! regulation of inclusion body assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140121 ! Lewy body formation relationship: regulates GO:0140121 ! Lewy body formation created_by: pg creation_date: 2017-10-25T07:03:29Z [Term] id: GO:0140123 name: negative regulation of Lewy body formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation." [GOC:sl] comment: Term request https://github.com/geneontology/go-ontology/issues/14160 is_a: GO:0090084 ! negative regulation of inclusion body assembly is_a: GO:0140122 ! regulation of Lewy body formation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140121 ! Lewy body formation relationship: negatively_regulates GO:0140121 ! Lewy body formation created_by: pg creation_date: 2017-10-25T07:08:56Z [Term] id: GO:0140124 name: positive regulation of Lewy body formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Lewy body formation." [GOC:sl] comment: Term request https://github.com/geneontology/go-ontology/issues/14160 is_a: GO:0090261 ! positive regulation of inclusion body assembly is_a: GO:0140122 ! regulation of Lewy body formation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140121 ! Lewy body formation relationship: positively_regulates GO:0140121 ! Lewy body formation created_by: pg creation_date: 2017-10-25T07:10:14Z [Term] id: GO:0140125 name: thiamine import across plasma membrane namespace: biological_process def: "The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] is_a: GO:0071934 ! thiamine transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: pg creation_date: 2017-10-25T11:09:23Z [Term] id: GO:0140131 name: positive regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000403 ! positive regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048247 ! lymphocyte chemotaxis relationship: positively_regulates GO:0048247 ! lymphocyte chemotaxis created_by: pg creation_date: 2017-11-02T10:26:40Z [Term] id: GO:0140132 name: iron-sulfur cluster carrier activity namespace: molecular_function def: "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule." [PMID:22966982, PMID:29051382] comment: New term request https://github.com/geneontology/go-ontology/issues/14539 is_a: GO:0140104 ! molecular carrier activity created_by: pg creation_date: 2017-11-10T08:55:38Z [Term] id: GO:0140133 name: suppression by symbiont of host cytokine secretion namespace: biological_process def: "Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine secretion in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23083102] comment: New term request https://github.com/geneontology/go-ontology/issues/14553 synonym: "negative regulation by symbiont of host cytokine secretion" EXACT [] is_a: GO:0052170 ! suppression by symbiont of host innate immune response created_by: pg creation_date: 2017-11-14T07:07:04Z [Term] id: GO:0140135 name: mechanosensitive cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a mechanical stress." [GOC:ha, PMID:22343900] comment: Term request https://github.com/geneontology/go-ontology/issues/14588 synonym: "mechanically-gated cation channel activity" EXACT [] is_a: GO:0005261 ! cation channel activity is_a: GO:0008381 ! mechanosensitive ion channel activity created_by: pg creation_date: 2017-11-17T12:40:37Z [Term] id: GO:0140140 name: mitochondrial guanine nucleotide transmembrane transport namespace: biological_process def: "The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:14998997] is_a: GO:1903716 ! guanine transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: pg creation_date: 2017-11-24T13:26:17Z [Term] id: GO:0140141 name: mitochondrial potassium ion transmembrane transport namespace: biological_process def: "The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:20197279] is_a: GO:0071805 ! potassium ion transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: pg creation_date: 2017-11-24T13:26:42Z [Term] id: GO:0140142 name: nucleocytoplasmic carrier activity namespace: molecular_function alt_id: GO:0061717 alt_id: GO:0090631 def: "Carries substances between the nucleus and the cytoplasm of a cell by moving along with the target protein." [GOC:pg] comment: New term created for https://github.com/geneontology/go-ontology/issues/14336. subset: gocheck_do_not_annotate synonym: "miRNA transporter activity" NARROW [] synonym: "nucleocytoplasmic importin/exportin activity" EXACT [] synonym: "pre-miRNA transporter activity" NARROW [] is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: part_of GO:0006913 ! nucleocytoplasmic transport relationship: part_of GO:0006913 ! nucleocytoplasmic transport created_by: pg creation_date: 2017-12-06T13:40:40Z [Term] id: GO:0140145 name: copper ion export from vacuole namespace: biological_process def: "The directed movement of copper ions out of the vacuole across the vacuolar membrane." [GOC:vw, PMID:12244050] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0060003 ! copper ion export created_by: pg creation_date: 2017-12-13T15:02:39Z [Term] id: GO:0140146 name: calcium ion import into vacuole namespace: biological_process def: "The directed movement of calcium cations into the vacuole across the vacuolar membrane." [GOC:vw, PMID:8628289] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0060401 ! cytosolic calcium ion transport is_a: GO:0070588 ! calcium ion transmembrane transport is_a: GO:1901660 ! calcium ion export created_by: pg creation_date: 2017-12-13T15:15:29Z [Term] id: GO:0140147 name: zinc ion export from vacuole namespace: biological_process def: "The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol." [GOC:vw, PMC:PMC203372] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0070839 ! divalent metal ion export is_a: GO:0071577 ! zinc ion transmembrane transport created_by: pg creation_date: 2017-12-13T15:21:10Z [Term] id: GO:0140157 name: ammonium import across plasma membrane namespace: biological_process def: "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:16999738] is_a: GO:0072488 ! ammonium transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: pg creation_date: 2018-01-26T12:39:56Z [Term] id: GO:0140159 name: borate export across plasma membrane namespace: biological_process def: "The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:17459946] is_a: GO:0035445 ! borate transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: pg creation_date: 2018-02-02T10:21:37Z [Term] id: GO:0140161 name: monocarboxylate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)." [GOC:ln, PMID:15322102] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity created_by: pg creation_date: 2018-02-05T10:33:55Z [Term] id: GO:0140164 name: Golgi transport complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Golgi transport complex, a multisubunit tethering complex of the CATCHR family." [GOC:ha, PMID:28100664] synonym: "COG complex binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: pg creation_date: 2018-02-08T11:49:38Z [Term] id: GO:0140192 name: regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0044057 ! regulation of system process is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process relationship: regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:06:38Z [Term] id: GO:0140193 name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0044057 ! regulation of system process is_a: GO:0071877 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process relationship: regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:08:49Z [Term] id: GO:0140194 name: negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0140193 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process relationship: negatively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:13:02Z [Term] id: GO:0140195 name: positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway is_a: GO:0140193 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process relationship: positively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:13:11Z [Term] id: GO:0140196 name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway is_a: GO:0106071 ! positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0140192 ! regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process relationship: positively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:13:29Z [Term] id: GO:0140199 name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0071878 ! negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway is_a: GO:0140192 ! regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process relationship: negatively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process created_by: pg creation_date: 2018-02-15T19:31:23Z [Term] id: GO:0140200 name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate namespace: biological_process def: "An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction." [GOC:BHF] is_a: GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process intersection_of: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway intersection_of: part_of GO:0002027 ! regulation of heart rate relationship: has_part GO:0086010 ! membrane depolarization during action potential relationship: part_of GO:0003062 ! regulation of heart rate by chemical signal created_by: pg creation_date: 2018-02-16T14:33:06Z [Term] id: GO:0140201 name: urea import across plasma membrane namespace: biological_process def: "The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313] is_a: GO:0071918 ! urea transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: pg creation_date: 2018-02-20T10:15:45Z [Term] id: GO:0140202 name: polyamine import across plasma membrane namespace: biological_process def: "The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0098739 ! import across plasma membrane created_by: pg creation_date: 2018-02-20T10:24:54Z [Term] id: GO:0140203 name: spermidine import across plasma membrane namespace: biological_process def: "The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] is_a: GO:0140157 ! ammonium import across plasma membrane is_a: GO:0140202 ! polyamine import across plasma membrane is_a: GO:1903711 ! spermidine transmembrane transport created_by: pg creation_date: 2018-02-21T19:10:07Z [Term] id: GO:0140204 name: pyridoxal import across plasma membrane namespace: biological_process def: "The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] is_a: GO:0098739 ! import across plasma membrane is_a: GO:1903090 ! pyridoxal transmembrane transport created_by: pg creation_date: 2018-02-21T19:17:27Z [Term] id: GO:0140205 name: oligopeptide import across plasma membrane namespace: biological_process def: "The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] is_a: GO:0035672 ! oligopeptide transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: pg creation_date: 2018-02-22T15:48:21Z [Term] id: GO:0140206 name: dipeptide import across plasma membrane namespace: biological_process def: "The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] is_a: GO:0035442 ! dipeptide transmembrane transport is_a: GO:0140205 ! oligopeptide import across plasma membrane created_by: pg creation_date: 2018-02-22T15:49:19Z [Term] id: GO:0140207 name: tripeptide import across plasma membrane namespace: biological_process def: "The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] is_a: GO:0035443 ! tripeptide transmembrane transport is_a: GO:0140205 ! oligopeptide import across plasma membrane created_by: pg creation_date: 2018-02-22T15:49:55Z [Term] id: GO:0140208 name: apoptotic process in response to mitochondrial fragmentation namespace: biological_process def: "Any apoptotic process that occurs as a result of mitochondrial fragmentation." [PMID:18940801] synonym: "apoptosis in response to mitochondrial fragmentation" EXACT [] is_a: GO:0006915 ! apoptotic process created_by: pg creation_date: 2018-03-08T16:54:17Z [Term] id: GO:0140209 name: zinc ion import into endoplasmic reticulum namespace: biological_process def: "The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum." [PMID:11886869, PMID:29529046] comment: This term covers zinc(2+) import *across* the endoplasmic reticulum membrane through a channel or pore. It does not cover import via vesicle fusion with endoplasmic reticulum membrane, as in this case transport does not involve crossing the membrane. synonym: "zinc ion import across endoplasmic reticulum" EXACT [] synonym: "zinc ion import into ER" EXACT [] synonym: "zinc(2+) import across endoplasmic reticulum" EXACT [] synonym: "zinc(2+) import into endoplasmic reticulum" EXACT [] is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport is_a: GO:0062111 ! zinc ion import into organelle created_by: pg creation_date: 2018-03-19T10:40:01Z [Term] id: GO:0140210 name: protein transport along microtubule to kinetochore namespace: biological_process def: "Any process in which a protein is transported to the kinetochore along a microtubule." [PMID:25472718] is_a: GO:0034501 ! protein localization to kinetochore is_a: GO:0070199 ! establishment of protein localization to chromosome is_a: GO:0098840 ! protein transport along microtubule created_by: pg creation_date: 2018-03-22T07:05:21Z [Term] id: GO:0140211 name: folic acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid." [PMID:24745983] xref: TC:2.A.1.50.1 is_a: GO:0008517 ! folic acid transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity created_by: pg creation_date: 2018-03-30T08:00:09Z [Term] id: GO:0140212 name: regulation of long-chain fatty acid import into cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239] is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044539 ! long-chain fatty acid import into cell relationship: regulates GO:0044539 ! long-chain fatty acid import into cell created_by: pg creation_date: 2018-04-10T15:10:41Z [Term] id: GO:0140213 name: negative regulation of long-chain fatty acid import into cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell" [PMID:28178239] is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell is_a: GO:2000192 ! negative regulation of fatty acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044539 ! long-chain fatty acid import into cell relationship: negatively_regulates GO:0044539 ! long-chain fatty acid import into cell created_by: pg creation_date: 2018-04-10T15:13:28Z [Term] id: GO:0140214 name: positive regulation of long-chain fatty acid import into cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239] is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell is_a: GO:2000193 ! positive regulation of fatty acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044539 ! long-chain fatty acid import into cell relationship: positively_regulates GO:0044539 ! long-chain fatty acid import into cell created_by: pg creation_date: 2018-04-10T15:15:03Z [Term] id: GO:0140215 name: regulation of D-aspartate import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] comment: New term requested https://github.com/geneontology/go-ontology/issues/15041 is_a: GO:0010958 ! regulation of amino acid import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070779 ! D-aspartate import across plasma membrane relationship: regulates GO:0070779 ! D-aspartate import across plasma membrane created_by: pg creation_date: 2018-04-11T15:33:35Z [Term] id: GO:0140216 name: negative regulation of D-aspartate import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] comment: New term requested https://github.com/geneontology/go-ontology/issues/15041 is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070779 ! D-aspartate import across plasma membrane relationship: negatively_regulates GO:0070779 ! D-aspartate import across plasma membrane created_by: pg creation_date: 2018-04-11T15:43:25Z [Term] id: GO:0140217 name: positive regulation of D-aspartate import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] comment: New term requested https://github.com/geneontology/go-ontology/issues/15041 is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070779 ! D-aspartate import across plasma membrane relationship: positively_regulates GO:0070779 ! D-aspartate import across plasma membrane created_by: pg creation_date: 2018-04-11T15:45:22Z [Term] id: GO:0140220 name: pathogen-containing vacuole namespace: cellular_component def: "A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides." [PMID:10560000, PMID:26842840] comment: New term request: https://github.com/geneontology/go-ontology/issues/15580 synonym: "pathogen inclusion" RELATED [] synonym: "pathogen-containing compartment" RELATED [] is_a: GO:0033643 ! host cell part created_by: pg creation_date: 2018-04-20T06:02:14Z [Term] id: GO:0140221 name: pathogen-containing vacuole membrane namespace: cellular_component def: "Host-derived membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840] comment: New term request: https://github.com/geneontology/go-ontology/issues/15580 synonym: "pathogen inclusion membrane" RELATED [] synonym: "pathogen-containing compartment membrane" EXACT [] is_a: GO:0016020 ! membrane relationship: part_of GO:0140220 ! pathogen-containing vacuole created_by: pg creation_date: 2018-04-20T06:18:25Z [Term] id: GO:0140222 name: pathogen-containing vacuole lumen namespace: cellular_component def: "The enclosed volume within the sealed membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840] comment: New term request: https://github.com/geneontology/go-ontology/issues/15580 synonym: "lumen of a pathogen-containing vacuole" EXACT [] synonym: "pathogen inclusion lumen" RELATED [] synonym: "pathogen-containing compartment lumen" EXACT [] synonym: "pathogen-containing vacuolar lumen" EXACT [] is_a: GO:0031974 ! membrane-enclosed lumen relationship: part_of GO:0140220 ! pathogen-containing vacuole created_by: pg creation_date: 2018-04-20T06:24:02Z [Term] id: GO:0140223 name: general transcription initiation factor activity namespace: molecular_function def: "An activity that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur. subset: gocheck_do_not_annotate synonym: "basal transcription factor activity" EXACT [] synonym: "general transcription factor activity" EXACT [] synonym: "GTF activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity relationship: part_of GO:0006351 ! transcription, DNA-templated created_by: pg creation_date: 2018-05-24T07:51:23Z [Term] id: GO:0140224 name: SLAC complex namespace: cellular_component def: "A protein complex that regulates Arp2/3 complex-mediated actin nucleation." [GOC:lnp, PMID:22973053] xref: IntAct:EBI-7506670 is_a: GO:0032991 ! protein-containing complex created_by: pg creation_date: 2018-05-29T09:54:08Z [Term] id: GO:0140225 name: DNA topoisomerase III-beta-TDRD3 complex namespace: cellular_component def: "A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities." [GOC:lnp, PMID:23912945, PMID:28176834] synonym: "Top3-beta-TDRD3 complex" EXACT [GOC:krc] is_a: GO:0032991 ! protein-containing complex created_by: pg creation_date: 2018-05-29T10:05:33Z [Term] id: GO:0140226 name: RNA topoisomerase activity namespace: molecular_function def: "Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA" [GOC:lnp, PMID:23912945, PMID:27257063] is_a: GO:0016853 ! isomerase activity is_a: GO:0140098 ! catalytic activity, acting on RNA created_by: pg creation_date: 2018-05-29T11:06:37Z [Term] id: GO:0140227 name: serotonin-gated cation-selective signaling pathway namespace: biological_process def: "A series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25392484, PMID:27764665] synonym: "5-HT-gated cation-selective signaling pathway" EXACT [] synonym: "5-HT-gated cation-selective signalling pathway" EXACT [] synonym: "5-hydroxytryptamine-gated cation-selective signaling pathway" EXACT [] synonym: "5-hydroxytryptamine-gated cation-selective signalling pathway" EXACT [] synonym: "serotonin-gated cation-selective signalling pathway" EXACT [] xref: ComplexPortal:CPX-2175 xref: ComplexPortal:CPX-271 xref: ComplexPortal:CPX-272 xref: ComplexPortal:CPX-273 xref: ComplexPortal:CPX-274 xref: ComplexPortal:CPX-275 xref: ComplexPortal:CPX-276 xref: ComplexPortal:CPX-277 xref: ComplexPortal:CPX-278 is_a: GO:0007210 ! serotonin receptor signaling pathway is_a: GO:1990806 ! ligand-gated ion channel signaling pathway created_by: pg creation_date: 2018-06-02T13:34:51Z [Term] id: GO:0140231 name: anterograde axonal transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:0099641 ! anterograde axonal protein transport created_by: pg creation_date: 2018-07-09T09:41:37Z [Term] id: GO:0140232 name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential." [PMID:21358644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231 subset: goslim_synapse synonym: "intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential" EXACT [] is_a: GO:0005222 ! intracellular cAMP-activated cation channel activity relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential created_by: pg creation_date: 2018-07-09T11:30:40Z [Term] id: GO:0140233 name: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential." [GOC:pvn] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231 subset: goslim_synapse synonym: "intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential" EXACT [] is_a: GO:0005222 ! intracellular cAMP-activated cation channel activity relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential created_by: pg creation_date: 2018-07-09T11:31:18Z [Term] id: GO:0140235 name: RNA polyadenylation at postsynapse namespace: biological_process def: "A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse." [PMID:22727665] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0043631 ! RNA polyadenylation intersection_of: GO:0043631 ! RNA polyadenylation intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-13T12:03:28Z [Term] id: GO:0140236 name: translation at presynapse namespace: biological_process def: "Translation that occurs at the presynapse." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216 subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0098793 ! presynapse relationship: occurs_in GO:0098793 ! presynapse created_by: pg creation_date: 2018-07-13T13:00:33Z [Term] id: GO:0140237 name: translation at presynapse, modulating chemical synaptic transmission namespace: biological_process def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216 subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0140236 ! translation at presynapse intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: regulates GO:0007268 ! chemical synaptic transmission created_by: pg creation_date: 2018-07-13T13:07:23Z [Term] id: GO:0140238 name: presynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230 subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: occurs_in GO:0098793 ! presynapse relationship: occurs_in GO:0098793 ! presynapse created_by: pg creation_date: 2018-07-15T07:33:55Z [Term] id: GO:0140239 name: postsynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230 subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-15T07:38:27Z [Term] id: GO:0140240 name: perforant pathway to dendrate granule cell synapse namespace: cellular_component def: "A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus." [PMID:22727665, PMID:29199135] comment: New term request https://github.com/geneontology/synapse/issues/234 subset: goslim_synapse synonym: "perforant pathway to DG granule cell synapse" EXACT [] is_a: GO:0045202 ! synapse created_by: pg creation_date: 2018-07-15T08:21:43Z [Term] id: GO:0140241 name: translation at synapse namespace: biological_process def: "Translation that occurs at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. subset: goslim_synapse is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0045202 ! synapse relationship: occurs_in GO:0045202 ! synapse created_by: pg creation_date: 2018-07-15T09:23:12Z [Term] id: GO:0140242 name: translation at postsynapse namespace: biological_process def: "Translation that occurs at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-15T09:26:27Z [Term] id: GO:0140243 name: regulation of translation at synapse namespace: biological_process def: "Any process that regulates translation occurring at the synapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. subset: goslim_synapse is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0045202 ! synapse intersection_of: regulates GO:0006412 ! translation relationship: occurs_in GO:0045202 ! synapse created_by: pg creation_date: 2018-07-15T09:38:26Z [Term] id: GO:0140244 name: regulation of translation at presynapse namespace: biological_process def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: regulates GO:0006412 ! translation relationship: occurs_in GO:0098793 ! presynapse created_by: pg creation_date: 2018-07-15T09:38:33Z [Term] id: GO:0140245 name: regulation of translation at postsynapse namespace: biological_process def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: regulates GO:0006412 ! translation relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-15T09:38:54Z [Term] id: GO:0140246 name: protein catabolic process at synapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0030163 ! protein catabolic process relationship: occurs_in GO:0045202 ! synapse created_by: pg creation_date: 2018-07-15T10:12:51Z [Term] id: GO:0140247 name: protein catabolic process at presynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse relationship: occurs_in GO:0098793 ! presynapse created_by: pg creation_date: 2018-07-15T10:23:49Z [Term] id: GO:0140249 name: protein catabolic process at postsynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-15T10:25:04Z [Term] id: GO:0140250 name: regulation protein catabolic process at synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0009894 ! regulation of catabolic process relationship: occurs_in GO:0045202 ! synapse created_by: pg creation_date: 2018-07-15T10:34:56Z [Term] id: GO:0140251 name: regulation protein catabolic process at presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse relationship: occurs_in GO:0098793 ! presynapse created_by: pg creation_date: 2018-07-15T10:35:39Z [Term] id: GO:0140252 name: regulation protein catabolic process at postsynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse relationship: occurs_in GO:0098794 ! postsynapse created_by: pg creation_date: 2018-07-15T10:35:56Z [Term] id: GO:0140253 name: cell-cell fusion namespace: biological_process def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion] comment: Created new term, see https://github.com/geneontology/go-ontology/issues/15939. synonym: "cell cell fusion" EXACT [] synonym: "cell fusion" BROAD [] is_a: GO:0009987 ! cellular process relationship: has_part GO:0045026 ! plasma membrane fusion created_by: pg creation_date: 2018-08-13T18:38:18Z [Term] id: GO:0140255 name: regulation of cellular response to phosphate starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016036 ! cellular response to phosphate starvation relationship: regulates GO:0016036 ! cellular response to phosphate starvation created_by: pg creation_date: 2018-09-07T17:11:42Z [Term] id: GO:0140256 name: negative regulation of cellular response to phosphate starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0140255 ! regulation of cellular response to phosphate starvation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016036 ! cellular response to phosphate starvation relationship: negatively_regulates GO:0016036 ! cellular response to phosphate starvation created_by: pg creation_date: 2018-09-07T17:11:42Z [Term] id: GO:0140259 name: PRC1 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PRC1 complex." [PMID:15280237] is_a: GO:0044877 ! protein-containing complex binding created_by: pg creation_date: 2018-09-10T16:48:18Z [Term] id: GO:0140260 name: mitochondrial proton-transporting ATP synthase complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitochondrial proton-transporting ATP synthase complex." [PMID:12110673] is_a: GO:0044877 ! protein-containing complex binding created_by: pg creation_date: 2018-09-10T19:38:26Z [Term] id: GO:0140261 name: BCOR complex namespace: cellular_component def: "A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes.\nIn mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10." [PMID:16943429, PMID:22325352, PMID:24515802] synonym: "BCL6 corepressor (BCOR) complex" EXACT [] synonym: "BCOR/BCORL1 complex" EXACT [] synonym: "non-canonical BCOR-PRC1.1 complex" EXACT [] synonym: "non-canonical PRC1-BCOR complex" EXACT [] synonym: "PRC1.1 complex" EXACT [] is_a: GO:0000152 ! nuclear ubiquitin ligase complex created_by: pg creation_date: 2018-09-11T09:35:05Z [Term] id: GO:0140262 name: mRNA cap binding complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mRNA cap binding complex." [PMID:16938833] is_a: GO:0044877 ! protein-containing complex binding created_by: pg creation_date: 2018-09-12T12:56:16Z [Term] id: GO:0140266 name: Woronin body namespace: cellular_component def: "Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes." [PMID:12640443, PMID:15155882, PMID:18227279, PMID:20707002, PMID:23882222] is_a: GO:0042579 ! microbody created_by: pg creation_date: 2018-09-24T14:53:37Z [Term] id: GO:0140267 name: viral entry via permeabilization of host membrane namespace: biological_process def: "The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm." [PMID:20427561, PMID:25055856] subset: gocheck_do_not_annotate is_a: GO:0046718 ! viral entry into host cell created_by: pg creation_date: 2018-09-25T14:33:03Z [Term] id: GO:0140268 name: endoplasmic reticulum-plasma membrane contact site namespace: cellular_component def: "A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696] synonym: "endoplasmic reticulum-plasma membrane contact junction" EXACT [] synonym: "EPCS" EXACT [] synonym: "ER-plasma membrane contact site" EXACT [] synonym: "ER-PM contact site" EXACT [] is_a: GO:0044232 ! organelle membrane contact site created_by: pg creation_date: 2018-09-26T09:29:41Z [Term] id: GO:0140270 name: gluconate import across plasma membrane namespace: biological_process def: "The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] is_a: GO:0035429 ! gluconate transmembrane transport is_a: GO:0098704 ! carbohydrate import across plasma membrane created_by: pg creation_date: 2018-10-01T08:47:35Z [Term] id: GO:0140271 name: hexose import across plasma membrane namespace: biological_process def: "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] is_a: GO:0008645 ! hexose transmembrane transport is_a: GO:0098704 ! carbohydrate import across plasma membrane created_by: pg creation_date: 2018-10-01T08:49:49Z [Term] id: GO:0140272 name: exogenous protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex from a different species, for example a pathogen molecule binding to a host protein (a complex of two or more proteins that may include other nonprotein molecules)." [PMID:28861068] comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant. is_a: GO:0005488 ! binding created_by: pg creation_date: 2018-10-01T10:03:21Z [Term] id: GO:0140273 name: repair of mitotic kinetochore microtubule attachment defect namespace: biological_process def: "The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536] synonym: "correction of mitotic kinetochore microtubule attachment defects" EXACT [] synonym: "repair of mitotic kinetochore microtubule attachment defects" EXACT [] is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007080 ! mitotic metaphase plate congression created_by: pg creation_date: 2018-10-01T11:29:24Z [Term] id: GO:0140274 name: repair of kinetochore microtubule attachment defect namespace: biological_process def: "The cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536] synonym: "correction of kinetochore microtubule attachment defects" EXACT [] synonym: "repair of kinetochore microtubule attachment defects" EXACT [] is_a: GO:0022402 ! cell cycle process created_by: pg creation_date: 2018-10-01T11:30:19Z [Term] id: GO:0140275 name: MIB complex namespace: cellular_component def: "A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1." [PMID:26477565] synonym: "mitochondrial intermembrane space bridging complex" EXACT [] synonym: "mitofilin complex" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane created_by: pg creation_date: 2018-10-01T17:10:27Z [Term] id: GO:0140278 name: mitotic division septum assembly namespace: biological_process def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [PMID:22786806] is_a: GO:0000917 ! division septum assembly is_a: GO:1902410 ! mitotic cytokinetic process created_by: pg creation_date: 2018-10-08T09:46:11Z [Term] id: GO:0140279 name: regulation of mitotic division septum assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] synonym: "regulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "regulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0032955 ! regulation of division septum assembly is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0140278 ! mitotic division septum assembly relationship: regulates GO:0140278 ! mitotic division septum assembly created_by: pg creation_date: 2018-10-08T09:55:51Z [Term] id: GO:0140280 name: negative regulation of mitotic division septum assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] synonym: "down regulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "down regulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "down regulation of mitotic division septum assembly" EXACT [] synonym: "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [] synonym: "down regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "down-regulation of mitotic division septum assembly" EXACT [] synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "downregulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "downregulation of mitotic division septum assembly" EXACT [] synonym: "downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "inhibition of division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic division septum assembly" NARROW [GOC:TermGenie] synonym: "inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "inhibition of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of division septum formation involved in mitotic cell cycle" EXACT [] synonym: "negative regulation of formation of division septum involved in mitotic cell cycle" EXACT [] synonym: "negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0010974 ! negative regulation of division septum assembly is_a: GO:0140279 ! regulation of mitotic division septum assembly is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0140278 ! mitotic division septum assembly relationship: negatively_regulates GO:0140278 ! mitotic division septum assembly created_by: pg creation_date: 2018-10-08T10:03:22Z [Term] id: GO:0140281 name: positive regulation of mitotic division septum assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] synonym: "activation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "activation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "activation of mitotic division septum assembly" EXACT [GOC:TermGenie] synonym: "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "activation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic division septum assembly" EXACT [] synonym: "positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic division septum assembly" EXACT [GOC:TermGenie] synonym: "up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic division septum assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0010973 ! positive regulation of division septum assembly is_a: GO:0140279 ! regulation of mitotic division septum assembly is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0140278 ! mitotic division septum assembly relationship: positively_regulates GO:0140278 ! mitotic division septum assembly created_by: pg creation_date: 2018-10-08T10:03:30Z [Term] id: GO:0140282 name: carbon-nitrogen ligase activity on lipid II namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate." [PMID:22291598, PMID:30093673, PMID:30154570] synonym: "carbon-nitrogen ligase activity on lipid II" EXACT [] synonym: "L-glutamate--lipid II transaminase activity" EXACT [] synonym: "undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity" EXACT [] xref: RHEA:57928 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor created_by: pg creation_date: 2018-10-08T19:12:57Z [Term] id: GO:0140284 name: endoplasmic reticulum-endosome membrane contact site namespace: cellular_component def: "A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460] synonym: "ER-endosome membrane contact site" EXACT [] is_a: GO:0044232 ! organelle membrane contact site created_by: pg creation_date: 2018-10-30T10:29:28Z [Term] id: GO:0140285 name: endosome fission namespace: biological_process def: "The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460] is_a: GO:0048285 ! organelle fission created_by: pg creation_date: 2018-10-30T10:36:33Z [Term] id: GO:0140288 name: GBAF complex namespace: cellular_component def: "A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM." [PMID:29374058] is_a: GO:0070603 ! SWI/SNF superfamily-type complex created_by: pg creation_date: 2018-11-20T09:13:52Z [Term] id: GO:0140289 name: protein mono-ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379] is_a: GO:0006471 ! protein ADP-ribosylation created_by: pg creation_date: 2018-11-22T13:52:54Z [Term] id: GO:0140290 name: peptidyl-serine ADP-deribosylation namespace: biological_process def: "The removal of ADP-ribose from ADP-ribosylserine." [PMID:28650317, PMID:29234005] is_a: GO:0051725 ! protein de-ADP-ribosylation created_by: pg creation_date: 2018-11-22T14:32:30Z [Term] id: GO:0140291 name: peptidyl-glutamate ADP-deribosylation namespace: biological_process def: "The removal of ADP-ribose from ADP-ribosylglutamate." [PMID:23481255] is_a: GO:0051725 ! protein de-ADP-ribosylation created_by: pg creation_date: 2018-11-22T14:34:24Z [Term] id: GO:0140292 name: ADP-ribosylserine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose." [PMID:28650317, PMID:29234005] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: pg creation_date: 2018-11-22T14:35:39Z [Term] id: GO:0140293 name: ADP-ribosylglutamate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose." [PMID:23481255] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds created_by: pg creation_date: 2018-11-22T14:36:37Z [Term] id: GO:0140294 name: NAD DNA ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA." [PMID:27471034, PMID:29361132, PMID:29520010] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups created_by: pg creation_date: 2018-11-22T15:45:35Z [Term] id: GO:0140295 name: pathogen-derived receptor ligand activity namespace: molecular_function def: "The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity." [PMID:20601497] synonym: "innate receptor ligand activity" RELATED [] is_a: GO:0048018 ! receptor ligand activity created_by: pg creation_date: 2018-11-26T13:30:21Z [Term] id: GO:0140296 name: general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] is_a: GO:0008134 ! transcription factor binding created_by: pg creation_date: 2018-11-28T12:48:06Z [Term] id: GO:0140297 name: DNA-binding transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] is_a: GO:0008134 ! transcription factor binding created_by: pg creation_date: 2018-11-28T12:48:20Z [Term] id: GO:0140298 name: endocytic iron import into cell namespace: biological_process def: "Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis." [PMID:23092063] synonym: "iron import into cell by endocytosis" EXACT [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0033212 ! iron import into cell created_by: pg creation_date: 2018-12-10T10:31:31Z [Term] id: GO:0140299 name: small molecule sensor activity namespace: molecular_function def: "Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879] synonym: "small molecular sensor activity" EXACT [] is_a: GO:0003674 ! molecular_function created_by: pg creation_date: 2018-12-10T14:30:28Z [Term] id: GO:0140300 name: serine import into mitochondrion namespace: biological_process def: "The process in which serine is transported from the cytosol, into the mitochondrial matrix." [PMID:30442778] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0032329 ! serine transport is_a: GO:0043090 ! amino acid import is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: pg creation_date: 2018-12-13T15:17:50Z [Term] id: GO:0140301 name: pollen-stigma interaction namespace: biological_process def: "The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae." [PMID:27899537] is_a: GO:0009875 ! pollen-pistil interaction created_by: pg creation_date: 2019-02-22T13:58:21Z [Term] id: GO:0140302 name: pollen-style interaction namespace: biological_process def: "The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte." [PMID:27899537] is_a: GO:0009875 ! pollen-pistil interaction created_by: pg creation_date: 2019-02-22T13:59:33Z [Term] id: GO:0140303 name: intramembrane lipid transporter activity namespace: molecular_function def: "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084] synonym: "flippase activity" RELATED [] is_a: GO:0005319 ! lipid transporter activity created_by: pg creation_date: 2019-03-01T20:14:09Z [Term] id: GO:0140306 name: lipoprotein releasing activity namespace: molecular_function def: "The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex." [PMID:10783239, PMID:21670534] comment: Created new term see https://github.com/geneontology/go-ontology/issues/17058 is_a: GO:0140318 ! protein transporter activity created_by: pg creation_date: 2019-03-22T14:25:43Z [Term] id: GO:0140311 name: protein sequestering activity namespace: molecular_function def: "The selective interaction of a protein with a specific protein, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333] is_a: GO:0140313 ! molecular sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005515 ! protein binding relationship: has_part GO:0005515 ! protein binding created_by: pg creation_date: 2019-03-26T14:34:16Z [Term] id: GO:0140312 name: cargo adaptor activity namespace: molecular_function alt_id: GO:0098748 def: "Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo, and membrane deformation machinery." [PMID:25795254] synonym: "endocytic adaptor activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0060090 ! molecular adaptor activity relationship: part_of GO:0016192 ! vesicle-mediated transport created_by: pg creation_date: 2019-03-26T17:01:45Z [Term] id: GO:0140313 name: molecular sequestering activity namespace: molecular_function def: "The selective interaction of a protein with a specific molecule, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005488 ! binding created_by: pg creation_date: 2019-03-28T10:00:25Z [Term] id: GO:0140314 name: calcium ion sequestering activity namespace: molecular_function def: "The selective interaction of a protein with a calcium ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] is_a: GO:0140313 ! molecular sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005509 ! calcium ion binding relationship: has_part GO:0005509 ! calcium ion binding created_by: pg creation_date: 2019-03-28T10:07:18Z [Term] id: GO:0140315 name: iron ion sequestering activity namespace: molecular_function def: "The selective interaction of a protein with an iron ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864] is_a: GO:0140313 ! molecular sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005506 ! iron ion binding relationship: has_part GO:0005506 ! iron ion binding created_by: pg creation_date: 2019-03-28T10:10:33Z [Term] id: GO:0140316 name: obsolete vesicular transport adaptor activity namespace: molecular_function def: "OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway." [PMID:25795254] comment: Thi sterm was obsoleted because it represented an unnecessary grouping class. is_obsolete: true created_by: pg creation_date: 2019-03-28T12:03:57Z [Term] id: GO:0140317 name: export across cell outer membrane namespace: biological_process def: "The directed movement of a substance across the outer membrane in cells with two membranes." [PMID:15968039] is_a: GO:0055085 ! transmembrane transport created_by: pg creation_date: 2019-04-01T08:12:23Z [Term] id: GO:0140318 name: protein transporter activity namespace: molecular_function def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. Created new term see https://github.com/geneontology/go-ontology/issues/17073 synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] is_a: GO:0005215 ! transporter activity created_by: pg creation_date: 2019-04-01T10:41:38Z [Term] id: GO:0140319 name: receptor decoy activity namespace: molecular_function alt_id: GO:0005040 def: "Recognizing, binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor." [Wikipedia:Decoy_receptors] synonym: "decoy death receptor activity" NARROW [] synonym: "decoy receptor" EXACT [] is_a: GO:0140313 ! molecular sequestering activity created_by: pg creation_date: 2019-04-02T10:57:46Z [Term] id: GO:0140320 name: PAMP receptor decoy activity namespace: molecular_function def: "A gene product which recognizes, binds and sequesters PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response." [PMID:20724636] synonym: "pathogen-associated molecular pattern receptor decoy activity" EXACT [] synonym: "pattern recognition receptor decoy activity" EXACT [] is_a: GO:0140319 ! receptor decoy activity created_by: pg creation_date: 2019-04-02T11:07:13Z [Term] id: GO:0140321 name: negative regulation by symbiont of host autophagy namespace: biological_process def: "Any process in which a symbiont organism decreases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0075071 ! modulation by symbiont of host autophagy intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: negatively_regulates GO:0006914 ! autophagy created_by: pg creation_date: 2019-04-03T09:21:48Z [Term] id: GO:0140323 name: solute:anion antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in)." [GOC:pg] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015297 ! antiporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity created_by: pg creation_date: 2019-04-03T16:23:14Z [Term] id: GO:0140325 name: negative regulation of protein localization to medial cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex." [PMID:30853434] is_a: GO:0106011 ! regulation of protein localization to medial cortex is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane is_a: GO:1904777 ! negative regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0071574 ! protein localization to medial cortex relationship: negatively_regulates GO:0071574 ! protein localization to medial cortex created_by: pg creation_date: 2019-04-17T11:58:27Z [Term] id: GO:0140326 name: ATPase-coupled intramembrane lipid transporter activity namespace: molecular_function alt_id: GO:0004012 alt_id: GO:0008557 def: "Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases." [PMID:16828084] synonym: "aminophospholipid-transporting ATPase" RELATED [] synonym: "ATPase-coupled phospholipid transporter activity" RELATED [] synonym: "ATPase-dependent phospholipid transporter activity" RELATED [] synonym: "phospholipid flippase activity" NARROW [] synonym: "phospholipid translocating ATPase activity" RELATED [] synonym: "phospholipid-translocating ATPase activity" RELATED [] synonym: "phospholipid-transporting ATPase activity" RELATED [EC:7.6.2.1] xref: EC:7.6.2.1 xref: MetaCyc:3.6.3.1-RXN xref: Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane" xref: Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" xref: RHEA:14989 is_a: GO:0140303 ! intramembrane lipid transporter activity created_by: pg creation_date: 2019-04-29T12:42:26Z [Term] id: GO:0140327 name: flippase activity namespace: molecular_function def: "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. synonym: "flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity created_by: pg creation_date: 2019-04-29T12:51:21Z [Term] id: GO:0140328 name: floppase activity namespace: molecular_function def: "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. synonym: "floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity relationship: has_part GO:0016887 ! ATPase activity created_by: pg creation_date: 2019-04-29T12:58:53Z [Term] id: GO:0140329 name: lysophospholipid translocation namespace: biological_process def: "The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [PMID:15661733] is_a: GO:0045332 ! phospholipid translocation is_a: GO:0051977 ! lysophospholipid transport created_by: pg creation_date: 2019-05-03T07:26:52Z [Term] id: GO:0140330 name: xenobiotic detoxification by transmembrane export across the cell outer membrane namespace: biological_process def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane." [PMID:11948170] is_a: GO:0042908 ! xenobiotic transport is_a: GO:0140317 ! export across cell outer membrane relationship: part_of GO:0098754 ! detoxification created_by: pg creation_date: 2019-05-03T10:35:57Z [Term] id: GO:0140331 name: aminophospholipid translocation namespace: biological_process def: "The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:pg] is_a: GO:0015917 ! aminophospholipid transport is_a: GO:0045332 ! phospholipid translocation created_by: pg creation_date: 2019-05-10T13:46:34Z [Term] id: GO:0140332 name: lipopolysaccharide transfer activity namespace: molecular_function def: "Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:24639492] synonym: "intermembrane lipopolysaccharide transfer activity" EXACT [] synonym: "intermembrane lipopolysaccharide transporter activity" EXACT [] synonym: "intermembrane LPS transporter activity" EXACT [] synonym: "lipopolysaccharide carrier activity" EXACT [] is_a: GO:0120013 ! lipid transfer activity relationship: part_of GO:0015920 ! lipopolysaccharide transport created_by: pg creation_date: 2019-05-13T08:17:35Z [Term] id: GO:0140333 name: glycerophospholipid flippase activity namespace: molecular_function def: "Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:26212235] synonym: "glycerophospholipid flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140327 ! flippase activity created_by: pg creation_date: 2019-05-13T11:14:56Z [Term] id: GO:0140334 name: lipopolysaccharide localization to cell outer membrane namespace: biological_process def: "A process in which a lipopolysaccharide is transported to the cell outer membrane." [PMID:24639492] synonym: "LPS localization to cell outer membrane" EXACT [] is_a: GO:0010876 ! lipid localization created_by: pg creation_date: 2019-05-13T12:23:36Z [Term] id: GO:0140337 name: diacylglyceride transfer activity namespace: molecular_function def: "Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] synonym: "diacylglyceride carrier activity" EXACT [] is_a: GO:0120013 ! lipid transfer activity created_by: pg creation_date: 2019-05-16T11:28:08Z [Term] id: GO:0140338 name: sphingomyelin transfer activity namespace: molecular_function alt_id: GO:0010175 def: "Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:9132017] synonym: "sphingomyelin carrier activity" EXACT [] synonym: "sphingosine transmembrane transporter activity" BROAD [] is_a: GO:0120014 ! phospholipid transfer activity is_a: GO:0120016 ! sphingolipid transfer activity created_by: pg creation_date: 2019-05-16T11:31:58Z [Term] id: GO:0140339 name: phosphatidylglycerol transfer activity namespace: molecular_function def: "Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] synonym: "phosphatidylglycerol carrier activity" EXACT [] is_a: GO:0120014 ! phospholipid transfer activity created_by: pg creation_date: 2019-05-16T11:34:45Z [Term] id: GO:0140340 name: cerebroside transfer activity namespace: molecular_function def: "Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] synonym: "cerebroside carrier activity" EXACT [] is_a: GO:0017089 ! glycolipid transfer activity is_a: GO:0120017 ! ceramide transfer activity created_by: pg creation_date: 2019-05-16T11:37:31Z [Term] id: GO:0140341 name: phosphatidylethanolamine floppase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:10029989] synonym: "phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140328 ! floppase activity created_by: pg creation_date: 2019-05-16T11:40:45Z [Term] id: GO:0140343 name: phosphatidylserine transfer activity namespace: molecular_function def: "Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:26206935] synonym: "intermembrane phosphatidylserine carrier activity" NARROW [] is_a: GO:0120014 ! phospholipid transfer activity created_by: pg creation_date: 2019-05-16T11:46:19Z [Term] id: GO:0140344 name: triglyceride transfer activity namespace: molecular_function def: "Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:23475612] synonym: "triglyceride carrier activity" EXACT [] is_a: GO:0120013 ! lipid transfer activity created_by: pg creation_date: 2019-05-16T11:53:59Z [Term] id: GO:0140345 name: phosphatidylcholine flippase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854] synonym: "phosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0008525 ! phosphatidylcholine transporter activity is_a: GO:0140333 ! glycerophospholipid flippase activity created_by: pg creation_date: 2019-05-16T13:43:47Z [Term] id: GO:0140346 name: phosphatidylserine flippase activity namespace: molecular_function def: "Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854] synonym: "phosphatidylserine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0015247 ! aminophospholipid flippase activity is_a: GO:0140333 ! glycerophospholipid flippase activity created_by: pg creation_date: 2019-05-16T13:44:23Z [Term] id: GO:0140347 name: N-retinylidene-phosphatidylethanolamine flippase activity namespace: molecular_function def: "Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:10412977] synonym: "N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0140333 ! glycerophospholipid flippase activity created_by: pg creation_date: 2019-05-16T13:44:51Z [Term] id: GO:0140348 name: lysophosphatidylcholine flippase activity namespace: molecular_function def: "Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:26945070] synonym: "lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0140333 ! glycerophospholipid flippase activity created_by: pg creation_date: 2019-05-16T13:45:17Z [Term] id: GO:0140351 name: glycosylceramide flippase activity namespace: molecular_function def: "Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar." [PMID:30530492] synonym: "galactocerebroside flippase activity" NARROW [] synonym: "galactosylceramide flippase activity" NARROW [] synonym: "glucosylceramide flippase activity" NARROW [] synonym: "glycoceramide flippase activity" EXACT [] synonym: "glycosylceramide flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0046624 ! sphingolipid transporter activity is_a: GO:0140327 ! flippase activity created_by: pg creation_date: 2019-05-20T13:29:48Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process created_by: pg creation_date: 2019-05-22T11:20:45Z [Term] id: GO:0140353 name: lipid export from cell namespace: biological_process def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell created_by: pg creation_date: 2019-05-22T11:33:07Z [Term] id: GO:0140354 name: lipid import into cell namespace: biological_process def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0098657 ! import into cell created_by: pg creation_date: 2019-05-22T11:38:15Z [Term] id: GO:0140355 name: cargo receptor ligand activity namespace: molecular_function def: "The activity of a gene product that interacts with a cargo receptor and initiates endocytosis." [PMID:15797858] synonym: "cargo" RELATED [] is_a: GO:0005488 ! binding created_by: pg creation_date: 2019-05-27T09:56:50Z [Term] id: GO:0140357 name: heme export from vacuole to cytoplasm namespace: biological_process def: "The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol." [PMID:28193844] comment: Create new term see https://github.com/geneontology/go-ontology/issues/17407 is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0035351 ! heme transmembrane transport is_a: GO:0097037 ! heme export created_by: pg creation_date: 2019-05-28T07:40:48Z [Term] id: GO:0140358 name: P-type transmembrane transporter activity namespace: molecular_function def: "Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [Wikipedia:P-type_ATPase] synonym: "E1-E2 ATPase" EXACT [Wikipedia:P-type_ATPase] synonym: "P-type ATPase" EXACT [] {comment="Wikipedia:P-type_ATPase"} xref: TC:3.A.3 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity created_by: pg creation_date: 2019-06-25T19:07:46Z [Term] id: GO:0140359 name: ABC-type transmembrane transporter activity namespace: molecular_function def: "Primary transporter characterized by two nucleotide-binding domains and two transmembrane domains. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [Wikipedia:ATP-binding_cassette_transporter] {comment="PMID:26517899"} synonym: "ABC transporter" EXACT [] synonym: "ABC-type efflux permease activity" EXACT [] synonym: "ABC-type efflux porter activity" EXACT [] synonym: "ABC-type uptake permease activity" EXACT [] synonym: "ATP binding cassette transporter" EXACT [] synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] synonym: "ATP-binding cassette transporter" EXACT [] xref: TC:3.A.1 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity created_by: pg creation_date: 2019-06-25T19:08:14Z [Term] id: GO:0140360 name: cyclic-GMP-AMP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other." [PMID:31126740] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity created_by: pg creation_date: 2019-07-02T14:49:32Z [Term] id: GO:0140361 name: cyclic-GMP-AMP transmembrane import across plasma membrane namespace: biological_process def: "The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol." [PMID:31126740] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:0070729 ! cyclic nucleotide transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:0098739 ! import across plasma membrane is_a: GO:1903790 ! guanine nucleotide transmembrane transport created_by: pg creation_date: 2019-07-02T15:49:24Z [Term] id: GO:0140362 name: cytoskeletal protein membrane adaptor namespace: molecular_function def: "Interacting selectively and non-covalently with both a cytoskeletal protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific membrane location." [PMID:30840879] synonym: "BAR domain adaptor" NARROW [] synonym: "F-BAR domain adaptor" NARROW [] is_a: GO:0008093 ! cytoskeletal adaptor activity is_a: GO:0043495 ! protein membrane adaptor relationship: has_part GO:0008289 ! lipid binding created_by: pg creation_date: 2019-07-08T14:05:20Z [Term] id: GO:0140363 name: TIS granule namespace: cellular_component def: "A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER)." [PMID:30449617, PMID:30479375, Wikipedia:TIGER_domain] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule created_by: pg creation_date: 2019-07-25T19:20:58Z [Term] id: GO:0140364 name: GW body namespace: cellular_component def: "A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs." [PMID:16418578, PMID:26930655, PMID:29576456] synonym: "GW-body" EXACT [] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule created_by: pg creation_date: 2019-07-25T19:26:48Z [Term] id: GO:0140365 name: RNP body namespace: cellular_component def: "A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules." [PMID:30197298] synonym: "BR-body" EXACT [] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule created_by: pg creation_date: 2019-07-25T19:31:17Z [Term] id: GO:0140366 name: galectin lattice namespace: cellular_component def: "A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids." [PMID:19021578, PMID:26092931, PMID:28893908, PMID:30951647] is_a: GO:0098635 ! protein complex involved in cell-cell adhesion created_by: pg creation_date: 2019-07-25T19:35:05Z [Term] id: GO:0140367 name: antibacterial innate immune response namespace: biological_process def: "An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:16177355, PMID:23006328] is_a: GO:0042742 ! defense response to bacterium is_a: GO:0045087 ! innate immune response created_by: pg creation_date: 2019-09-09T11:02:47Z [Term] id: GO:0140368 name: decoy receptor complex namespace: cellular_component def: "A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound." [GOC:bhm, PMID:30621730, PMID:9168977] synonym: "osteoclastogenesis inhibitory factor" NARROW [] synonym: "osteoprotegerin complex" NARROW [] is_a: GO:0043235 ! receptor complex created_by: pg creation_date: 2019-09-13T16:39:24Z [Term] id: GO:0140372 name: histone H3 ubiquitination namespace: biological_process def: "The modification of histone H3 by the addition of one or more ubiquitin groups." [GOC:mah, PMID:31468675] synonym: "histone H3 ubiquitylation" EXACT [] is_a: GO:0016574 ! histone ubiquitination created_by: pg creation_date: 2019-10-03T15:29:54Z [Term] id: GO:0140373 name: histone H3-K14 ubiquitination namespace: biological_process def: "The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone." [GOC:mah, PMID:31468675] synonym: "histone H3 ubiquitination at K14" EXACT [] synonym: "histone H3-K14 ubiquitylation" EXACT [] synonym: "histone H3K14 ubiquitination" EXACT [] is_a: GO:0140372 ! histone H3 ubiquitination created_by: pg creation_date: 2019-10-03T15:31:15Z [Term] id: GO:0140374 name: antiviral innate immune response namespace: biological_process def: "A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:31006531] is_a: GO:0045087 ! innate immune response is_a: GO:0051607 ! defense response to virus created_by: pg creation_date: 2019-10-10T16:41:12Z [Term] id: GO:0140375 name: immune receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor] is_a: GO:0038023 ! signaling receptor activity created_by: pg creation_date: 2019-10-18T14:11:15Z [Term] id: GO:0140376 name: innate immune receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in a cell to initiate an innate immune response." [PMID:28921463, PMID:31415752] is_a: GO:0140375 ! immune receptor activity created_by: pg creation_date: 2019-10-18T14:21:28Z [Term] id: GO:0140380 name: psilocybin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product." [PMID:28763571] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process relationship: has_part GO:0140382 ! tryptamine 4-monooxygenase activity relationship: has_part GO:0140383 ! 4-hydroxytryptamine kinase activity created_by: pg creation_date: 2019-11-20T10:03:05Z [Term] id: GO:0140381 name: 4-hydroxytryptamine 4-phosphate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin." [PMID:28763571] synonym: "norbaeocystin methyltransferase" EXACT [] synonym: "psilocybin synthase" EXACT [] xref: EC:2.1.1.345 xref: RHEA:55568 is_a: GO:0008168 ! methyltransferase activity created_by: pg creation_date: 2019-11-20T10:16:28Z [Term] id: GO:0140382 name: tryptamine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tryptamine + reduced acceptor + O(2) <=> 4-hydroxytryptamine + acceptor + H(2)O." [PMID:28763571] xref: EC:1.14.99.59 xref: RHEA:15865 is_a: GO:0004497 ! monooxygenase activity created_by: pg creation_date: 2019-11-20T10:26:21Z [Term] id: GO:0140383 name: 4-hydroxytryptamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)." [PMID:28763571] xref: EC:2.7.1.222 xref: RHEA:55564 is_a: GO:0016301 ! kinase activity created_by: pg creation_date: 2019-11-20T10:30:05Z [Term] id: GO:0140384 name: metacyclogenesis namespace: biological_process def: "The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania." [PMID:12152483, PMID:21514274, PMID:2659372, PMID:29091711, PMID:29409544] is_a: GO:0044114 ! development of symbiont in host created_by: pg creation_date: 2019-11-20T13:25:55Z [Term] id: GO:0140393 name: norsolorinic acid ketoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (1'S)-averantin + NADP(+) <=> norsolorinic acid + NADPH." [PMID:10584035, PMID:8368836, RHEA:35447] xref: EC:1.1.1.349 xref: KEGG_REACTION:R10309 xref: MetaCyc:RXN-9480 xref: RHEA:35447 is_a: GO:0045703 ! ketoreductase activity created_by: pg creation_date: 2019-11-28T14:38:12Z [Term] id: GO:0140394 name: ATPase-coupled azole transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)." [PMID:31501141] synonym: "azole ABC transporter activity" EXACT [] is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity created_by: pg creation_date: 2019-11-28T18:29:48Z [Term] id: GO:0140395 name: averantin hydroxylase activity namespace: molecular_function def: "Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O. Involved in aflatoxin biosynthesis." [EC:1.14.14.116, PMID:8368836] xref: EC:1.14.14.116 xref: MetaCyc:RXN-9482 xref: RHEA:35575 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen relationship: part_of GO:0045122 ! aflatoxin biosynthetic process created_by: pg creation_date: 2019-11-29T08:48:23Z [Term] id: GO:0140396 name: 5'-hydroxyaverantin dehydrogenase activity namespace: molecular_function def: "Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD(+) <=> 5'-oxoaverantin + NADH." [EC:1.1.1.352, PMID:14602595] xref: EC:1.1.1.352 xref: RHEA:35475 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: pg creation_date: 2019-11-29T08:56:49Z [Term] id: GO:0140397 name: versiconal hemiacetal acetate esterase activity namespace: molecular_function def: "Catalyzes the reactions: versiconal hemiacetal acetate + H(2)O <=> versiconal + acetate, as well as versiconol acetate + H(2)O <=> versiconol + acetate." [EC:3.1.1.94, PMID:15006741, PMID:15932995, PMID:8368837] xref: EC:3.1.1.94 xref: MetaCyc:RXN-9488 xref: MetaCyc:RXN-9493 xref: RHEA:35715 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds created_by: pg creation_date: 2019-11-29T10:14:17Z [Term] id: GO:0140398 name: versicolorin B desaturase activity namespace: molecular_function def: "Catalyzes the reaction: versicolorin B + NADPH + O(2) <=> versicolorin A + NADP(+) + 2 H(2)O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus." [PMID:15006741, PMID:8368837] xref: KEGG_REACTION:R10479 xref: MetaCyc:RXN-9495 xref: RHEA:35743 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water created_by: pg creation_date: 2019-11-29T10:30:25Z [Term] id: GO:0140399 name: aflatoxin B synthase activity namespace: molecular_function def: "Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H(2)O + methanol + CO(2). Produces both aflatoxin B(1) and aflatoxin B(2)." [EC:1.14.14.117] xref: EC:1.14.14.117 xref: MetaCyc:RXN-9497 xref: MetaCyc:RXN-9502 xref: RHEA:35759 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen relationship: part_of GO:0045122 ! aflatoxin biosynthetic process created_by: pg creation_date: 2019-11-29T11:06:07Z [Term] id: GO:0140403 name: effector-mediated suppression of host innate immune response by symbiont namespace: biological_process def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214, PMID:30584105] synonym: "effector dependent suppression of host immune innate response by symbiont" EXACT [] synonym: "effector triggered suppression of host immune innate response by symbiont" EXACT [] synonym: "effector-dependent suppression of host immune innate response by symbiont" EXACT [] synonym: "effector-mediated suppression of host immune innate response by symbiont" EXACT [] synonym: "effector-triggered suppression of host immune innate response by symbiont" EXACT [] synonym: "suppression of effector-triggered immunity (PTI)" EXACT [] is_a: GO:0140404 ! effector-mediated modulation of host immune response by symbiont created_by: pg creation_date: 2019-12-05T11:34:55Z [Term] id: GO:0140404 name: effector-mediated modulation of host immune response by symbiont namespace: biological_process def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214] synonym: "effector mediated modulation of host immune response by symbiont" EXACT [] synonym: "effector triggered modulation of host immune response by symbiont" EXACT [] synonym: "effector-dependent modulation of host immune response by symbiont" EXACT [] synonym: "effector-triggered modulation of host immune response by symbiont" EXACT [] is_a: GO:0052553 ! modulation by symbiont of host immune response created_by: pg creation_date: 2019-12-05T11:38:44Z [Term] id: GO:0140405 name: spindle pole body-led chromosome movement during mitotic interphase namespace: biological_process def: "A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase." [PMID:31483748] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0051303 ! establishment of chromosome localization is_a: GO:0070632 ! establishment of spindle pole body localization relationship: happens_during GO:0051329 ! mitotic interphase created_by: pg creation_date: 2019-12-10T09:13:47Z [Term] id: GO:0140406 name: L-alanine export across the plasma membrane namespace: biological_process def: "The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:26073055, PMID:31591285] is_a: GO:0032973 ! amino acid export across plasma membrane is_a: GO:1904557 ! L-alanine transmembrane transport created_by: pg creation_date: 2019-12-11T14:13:07Z [Term] id: GO:0140407 name: L-alanine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)." [PMID:26073055, PMID:31591285] is_a: GO:0015180 ! L-alanine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity created_by: pg creation_date: 2019-12-11T14:17:48Z [Term] id: GO:0140408 name: regulation of mRNA alternative polyadenylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755] comment: Created new term as requested in https://github.com/geneontology/go-ontology/issues/15389. is_a: GO:1900363 ! regulation of mRNA polyadenylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0110104 ! mRNA alternative polyadenylation relationship: regulates GO:0110104 ! mRNA alternative polyadenylation created_by: pg creation_date: 2019-12-13T12:48:14Z [Term] id: GO:0140409 name: positive regulation of mRNA alternative polyadenylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755] comment: Created new term as requested in https://github.com/geneontology/go-ontology/issues/15389. is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0140408 ! regulation of mRNA alternative polyadenylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0110104 ! mRNA alternative polyadenylation relationship: positively_regulates GO:0110104 ! mRNA alternative polyadenylation created_by: pg creation_date: 2019-12-13T12:48:31Z [Term] id: GO:0150001 name: primary dendrite namespace: cellular_component def: "A dendrite emerging from the cell body (the soma) of a neuron." [GOC:aruk, GOC:bc] is_a: GO:0030425 ! dendrite [Term] id: GO:0150002 name: distal dendrite namespace: cellular_component def: "The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:20629984] is_a: GO:0030425 ! dendrite [Term] id: GO:0150003 name: regulation of spontaneous synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission." [GOC:aruk, GOC:bc, PMID:15457210] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098814 ! spontaneous synaptic transmission relationship: regulates GO:0098814 ! spontaneous synaptic transmission [Term] id: GO:0150004 name: dendritic spine origin namespace: cellular_component def: "The part of the dendritic spine neck where the spine arises from the dendritic shaft." [GOC:aruk, GOC:bc, PMID:9030614] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0044326 ! dendritic spine neck [Term] id: GO:0150005 name: enzyme activator complex namespace: cellular_component def: "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active." [GOC:bhm, PMID:16244137, PMID:28710280] xref: IntAct:EBI-16417801 is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0150006 name: urease activator complex namespace: cellular_component def: "A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function." [GOC:bhm, PMID:16244137, PMID:28710280] xref: IntAct:EBI-16417801 is_a: GO:0150005 ! enzyme activator complex [Term] id: GO:0150007 name: clathrin-dependent synaptic vesicle endocytosis namespace: biological_process def: "Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786] is_a: GO:0046907 ! intracellular transport is_a: GO:0048488 ! synaptic vesicle endocytosis is_a: GO:0072583 ! clathrin-dependent endocytosis relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome created_by: BarbaraCzub creation_date: 2017-12-01T10:11:35Z [Term] id: GO:0150008 name: bulk synaptic vesicle endocytosis namespace: biological_process def: "Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse." [GOC:aruk, GOC:bc, GOC:ha, PMID:18250322, PMID:18579735, PMID:19266323, PMID:26430111, PMID:28391090] synonym: "activity-dependent bulk endocytosis" EXACT [] synonym: "activity-dependent bulk synaptic vesicle endocytosis" EXACT [] synonym: "ADBE" EXACT [] synonym: "bulk endocytosis" EXACT [] is_a: GO:0048488 ! synaptic vesicle endocytosis created_by: BarbaraCzub creation_date: 2017-12-01T10:20:18Z [Term] id: GO:0150011 name: regulation of neuron projection arborization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] synonym: "regulation of neurite arborization" EXACT [] synonym: "regulation of neurite branching" EXACT [] synonym: "regulation of neuron projection branching" EXACT [] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0140058 ! neuron projection arborization relationship: regulates GO:0140058 ! neuron projection arborization created_by: BarbaraCzub creation_date: 2017-12-13T16:32:34Z [Term] id: GO:0150012 name: positive regulation of neuron projection arborization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] synonym: "positive regulation of neurite arborization" EXACT [] synonym: "positive regulation of neurite branching" EXACT [] synonym: "positive regulation of neuron projection branching" EXACT [] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0150011 ! regulation of neuron projection arborization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0140058 ! neuron projection arborization relationship: positively_regulates GO:0140058 ! neuron projection arborization created_by: BarbaraCzub creation_date: 2017-12-13T16:46:57Z [Term] id: GO:0150013 name: negative regulation of neuron projection arborization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] synonym: "negative regulation of neurite arborization" EXACT [] synonym: "negative regulation of neurite branching" EXACT [] synonym: "negative regulation of neuron projection branching" EXACT [] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0150011 ! regulation of neuron projection arborization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0140058 ! neuron projection arborization relationship: negatively_regulates GO:0140058 ! neuron projection arborization created_by: BarbaraCzub creation_date: 2017-12-13T16:50:53Z [Term] id: GO:0150014 name: apical distal dendrite namespace: cellular_component def: "Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma)." [GO:bc, GOC:aruk, PMID:1720142, PMID:20629984, PMID:9214543] is_a: GO:0097440 ! apical dendrite is_a: GO:0150002 ! distal dendrite created_by: BarbaraCzub creation_date: 2017-12-21T12:03:28Z [Term] id: GO:0150015 name: apical proximal dendrite namespace: cellular_component def: "The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:1720142, PMID:9214543] is_a: GO:0097440 ! apical dendrite is_a: GO:1990635 ! proximal dendrite created_by: BarbaraCzub creation_date: 2017-12-21T12:09:26Z [Term] id: GO:0150016 name: basal distal dendrite namespace: cellular_component def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:17046728, PMID:1720142, PMID:20629984, PMID:22683681, PMID:9214543] is_a: GO:0097441 ! basal dendrite is_a: GO:0150002 ! distal dendrite created_by: BarbaraCzub creation_date: 2017-12-21T12:11:47Z [Term] id: GO:0150017 name: basal proximal dendrite namespace: cellular_component def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:17046728, PMID:1720142, PMID:22683681, PMID:9214543] is_a: GO:0097441 ! basal dendrite is_a: GO:1990635 ! proximal dendrite created_by: BarbaraCzub creation_date: 2017-12-21T12:17:00Z [Term] id: GO:0150018 name: basal dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0016358 ! dendrite development created_by: BarbaraCzub creation_date: 2017-12-22T11:09:53Z [Term] id: GO:0150019 name: basal dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a basal dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0048813 ! dendrite morphogenesis relationship: part_of GO:0150018 ! basal dendrite development created_by: BarbaraCzub creation_date: 2017-12-22T11:26:07Z [Term] id: GO:0150020 name: basal dendrite arborization namespace: biological_process def: "The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0140059 ! dendrite arborization is_a: GO:0150019 ! basal dendrite morphogenesis created_by: BarbaraCzub creation_date: 2017-12-22T11:32:31Z [Term] id: GO:0150021 name: apical dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an apical dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0048813 ! dendrite morphogenesis relationship: part_of GO:0150022 ! apical dendrite development created_by: BarbaraCzub creation_date: 2017-12-22T11:50:00Z [Term] id: GO:0150022 name: apical dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0016358 ! dendrite development created_by: BarbaraCzub creation_date: 2017-12-22T11:52:40Z [Term] id: GO:0150023 name: apical dendrite arborization namespace: biological_process def: "The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681] is_a: GO:0140059 ! dendrite arborization is_a: GO:0150021 ! apical dendrite morphogenesis created_by: BarbaraCzub creation_date: 2017-12-22T11:56:05Z [Term] id: GO:0150024 name: oxidised low-density lipoprotein particle clearance namespace: biological_process def: "The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:aruk, GOC:bc, PMID:27607416] synonym: "ox-LDL particle clearance" EXACT [] synonym: "oxidised LDL particle clearance" EXACT [] synonym: "oxidized LDL particle clearance" EXACT [] synonym: "oxidized low-density lipoprotein particle clearance" EXACT [] synonym: "oxLDL particle clearance" EXACT [] is_a: GO:0034381 ! plasma lipoprotein particle clearance created_by: BarbaraCzub creation_date: 2018-02-05T16:14:05Z [Term] id: GO:0150025 name: oxidised low-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis." [GOC:aruk, GOC:bc, PMID:27607416] synonym: "ox-LDL particle receptor activity" EXACT [] synonym: "ox-LDL receptor activity" RELATED [] synonym: "oxidised LDL particle receptor activity" EXACT [] synonym: "oxidised LDL receptor activity" RELATED [] synonym: "oxidised low-density lipoprotein receptor activity" RELATED [] synonym: "oxidized LDL particle receptor activity" EXACT [] synonym: "oxidized LDL receptor activity" RELATED [] synonym: "oxidized low-density lipoprotein particle receptor activity" EXACT [] synonym: "oxidized low-density lipoprotein receptor activity" RELATED [] synonym: "oxLDL particle receptor activity" EXACT [] synonym: "oxLDL receptor activity" RELATED [] is_a: GO:0030228 ! lipoprotein particle receptor activity created_by: BarbaraCzub creation_date: 2018-02-06T14:17:33Z [Term] id: GO:0150031 name: regulation of protein localization to lysosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061462 ! protein localization to lysosome relationship: regulates GO:0061462 ! protein localization to lysosome created_by: BarbaraCzub creation_date: 2018-02-06T17:07:03Z [Term] id: GO:0150032 name: positive regulation of protein localization to lysosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061462 ! protein localization to lysosome relationship: positively_regulates GO:0061462 ! protein localization to lysosome created_by: BarbaraCzub creation_date: 2018-02-06T17:11:02Z [Term] id: GO:0150033 name: negative regulation of protein localization to lysosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061462 ! protein localization to lysosome relationship: negatively_regulates GO:0061462 ! protein localization to lysosome created_by: BarbaraCzub creation_date: 2018-02-06T17:14:16Z [Term] id: GO:0150034 name: distal axon namespace: cellular_component def: "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] synonym: "distal part of axon" EXACT [] synonym: "distal part of the axon" EXACT [PMID:17202468] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon created_by: BarbaraCzub creation_date: 2018-02-19T15:04:24Z [Term] id: GO:0150035 name: regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:19448629] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099183 ! trans-synaptic signaling by BDNF, modulating synaptic transmission relationship: regulates GO:0099183 ! trans-synaptic signaling by BDNF, modulating synaptic transmission created_by: BarbaraCzub creation_date: 2018-04-17T13:56:34Z [Term] id: GO:0150036 name: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:27296803] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099553 ! trans-synaptic signaling by endocannabinoid, modulating synaptic transmission relationship: regulates GO:0099553 ! trans-synaptic signaling by endocannabinoid, modulating synaptic transmission created_by: BarbaraCzub creation_date: 2018-04-18T09:54:49Z [Term] id: GO:0150037 name: regulation of calcium-dependent activation of synaptic vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion." [GOC:aruk, GOC:bc, PMID:27052163] subset: goslim_synapse is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099502 ! calcium-dependent activation of synaptic vesicle fusion relationship: regulates GO:0099502 ! calcium-dependent activation of synaptic vesicle fusion created_by: BarbaraCzub creation_date: 2018-04-18T12:47:38Z [Term] id: GO:0150038 name: postsynaptic dense core vesicle exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels." [GOC:aruk, GOC:bc, PMID:19448629] subset: goslim_synapse is_a: GO:0099003 ! vesicle-mediated transport in synapse is_a: GO:0099011 ! neuronal dense core vesicle exocytosis intersection_of: GO:0099011 ! neuronal dense core vesicle exocytosis intersection_of: occurs_in GO:0098794 ! postsynapse relationship: occurs_in GO:0098794 ! postsynapse created_by: BarbaraCzub creation_date: 2018-04-18T14:32:16Z [Term] id: GO:0150043 name: structural constituent of synapse-associated extracellular matrix namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:aruk, GOC:bc, PMID:17189701] subset: goslim_synapse synonym: "extra-synaptic extracellular matrix structural constituent" EXACT [] synonym: "structural constituent of extra-synaptic extracellular matrix" EXACT [] synonym: "synapse-associated extracellular matrix structural constituent" EXACT [] is_a: GO:0005201 ! extracellular matrix structural constituent intersection_of: GO:0005201 ! extracellular matrix structural constituent intersection_of: occurs_in GO:0099535 ! synapse-associated extracellular matrix relationship: occurs_in GO:0099535 ! synapse-associated extracellular matrix created_by: BarbaraCzub creation_date: 2018-04-19T13:42:40Z [Term] id: GO:0150044 name: regulation of postsynaptic dense core vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis." [GOC:aruk, GOC:bc, PMID:19448629] subset: goslim_synapse is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150038 ! postsynaptic dense core vesicle exocytosis relationship: regulates GO:0150038 ! postsynaptic dense core vesicle exocytosis created_by: BarbaraCzub creation_date: 2018-04-20T13:34:32Z [Term] id: GO:0150045 name: regulation of synaptic signaling by nitric oxide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide." [GOC:aruk, GOC:bc, PMID:26311509] subset: goslim_synapse is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099163 ! synaptic signaling by nitric oxide relationship: regulates GO:0099163 ! synaptic signaling by nitric oxide created_by: BarbaraCzub creation_date: 2018-04-23T09:42:25Z [Term] id: GO:0150047 name: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential namespace: molecular_function def: "G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential." [GOC:aruk, GOC:bc, PMID:11498050] subset: goslim_synapse synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential" EXACT [] is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: part_of GO:0099505 ! regulation of presynaptic membrane potential relationship: occurs_in GO:0042734 ! presynaptic membrane relationship: part_of GO:0099505 ! regulation of presynaptic membrane potential created_by: BarbaraCzub creation_date: 2018-04-23T10:51:20Z [Term] id: GO:0150048 name: cerebellar granule cell to Purkinje cell synapse namespace: cellular_component def: "A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum." [GOC:aruk, GOC:bc, PMID:12427822] subset: goslim_synapse synonym: "cerebellar parallel fiber to Purkinje cell synapse" EXACT [] is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse created_by: BarbaraCzub creation_date: 2018-04-23T14:44:40Z [Term] id: GO:0150050 name: postsynaptic septin cytoskeleton namespace: cellular_component def: "The portion of the septin cytoskeleton contained within the postsynapse." [GOC:aruk, GOC:bc, PMID:28065648] subset: goslim_synapse is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton created_by: BarbaraCzub creation_date: 2018-04-26T14:45:52Z [Term] id: GO:0150051 name: postsynaptic Golgi apparatus namespace: cellular_component def: "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184] subset: goslim_synapse synonym: "Golgi outpost" RELATED [GOC:aruk, GOC:bc, PMID:21215635] is_a: GO:0005794 ! Golgi apparatus relationship: part_of GO:0098794 ! postsynapse created_by: BarbaraCzub creation_date: 2018-05-08T15:42:56Z [Term] id: GO:0150052 name: regulation of postsynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854] subset: goslim_synapse is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099068 ! postsynapse assembly relationship: regulates GO:0099068 ! postsynapse assembly created_by: BarbaraCzub creation_date: 2018-05-08T16:38:55Z [Term] id: GO:0150053 name: cerebellar climbing fiber to Purkinje cell synapse namespace: cellular_component def: "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata." [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254] subset: goslim_synapse synonym: "cerebellar climbing fibre to Purkinje cell synapse" EXACT [] is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse created_by: BarbaraCzub creation_date: 2018-05-09T09:57:20Z [Term] id: GO:0150054 name: regulation of postsynaptic neurotransmitter receptor diffusion trapping namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping." [GOC:aruk, GOC:bc, PMID:20935643] subset: goslim_synapse is_a: GO:0098696 ! regulation of neurotransmitter receptor localization to postsynaptic specialization membrane intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0098970 ! postsynaptic neurotransmitter receptor diffusion trapping relationship: regulates GO:0098970 ! postsynaptic neurotransmitter receptor diffusion trapping created_by: BarbaraCzub creation_date: 2018-05-10T14:26:59Z [Term] id: GO:0150056 name: amylin receptor complex 1 namespace: cellular_component def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY1 complex" EXACT [] is_a: GO:1903440 ! amylin receptor complex created_by: BarbaraCzub creation_date: 2018-06-21T10:47:10Z [Term] id: GO:0150057 name: amylin receptor complex 2 namespace: cellular_component def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY2 complex" EXACT [] is_a: GO:1903440 ! amylin receptor complex created_by: BarbaraCzub creation_date: 2018-06-21T10:51:35Z [Term] id: GO:0150058 name: amylin receptor complex 3 namespace: cellular_component def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signalling pathways." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY3 complex" EXACT [] is_a: GO:1903440 ! amylin receptor complex created_by: BarbaraCzub creation_date: 2018-06-21T10:54:00Z [Term] id: GO:0150059 name: amylin receptor 1 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY1 signaling pathway" EXACT [] is_a: GO:0097647 ! amylin receptor signaling pathway created_by: BarbaraCzub creation_date: 2018-06-21T10:58:02Z [Term] id: GO:0150060 name: amylin receptor 2 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY2 signaling pathway" EXACT [] is_a: GO:0097647 ! amylin receptor signaling pathway created_by: BarbaraCzub creation_date: 2018-06-21T11:00:22Z [Term] id: GO:0150061 name: amylin receptor 3 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos." [GOC:aruk, GOC:bc, PMID:22500019] synonym: "AMY3 signaling pathway" EXACT [] is_a: GO:0097647 ! amylin receptor signaling pathway created_by: BarbaraCzub creation_date: 2018-06-21T11:02:09Z [Term] id: GO:0150062 name: complement-mediated synapse pruning namespace: biological_process def: "Synaptic pruning mediated by complement system signalling." [GOC:aruk, GOC:bc, PMID:18083105, PMID:22632727, PMID:29844190] synonym: "complement-dependent synapse pruning" EXACT [] synonym: "synapse clearance" BROAD [] synonym: "synapse disassembly" BROAD [] synonym: "synapse elimination" BROAD [] synonym: "synapse removal" BROAD [] is_a: GO:0098883 ! synapse pruning created_by: BarbaraCzub creation_date: 2018-07-16T17:44:59Z [Term] id: GO:0150063 name: visual system development namespace: biological_process def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727] synonym: "optic pathway development" RELATED [] synonym: "visual pathway development" RELATED [] is_a: GO:0048880 ! sensory system development created_by: BarbaraCzub creation_date: 2018-07-23T10:31:58Z [Term] id: GO:0150064 name: vertebrate eye-specific patterning namespace: biological_process def: "Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus." [GOC:aruk, GOC:bc, PMID:16025107, PMID:22632727, PMID:29322522] synonym: "binocular vision development" RELATED [] synonym: "eye-specific patterning" BROAD [] synonym: "eye-specific segregation" BROAD [] synonym: "vertebrate eye-specific segregation" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0150063 ! visual system development created_by: BarbaraCzub creation_date: 2018-07-23T10:39:44Z [Term] id: GO:0150065 name: regulation of deacetylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019213 ! deacetylase activity relationship: regulates GO:0019213 ! deacetylase activity created_by: BarbaraCzub creation_date: 2018-07-23T12:24:28Z [Term] id: GO:0150066 name: negative regulation of deacetylase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0150065 ! regulation of deacetylase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019213 ! deacetylase activity relationship: negatively_regulates GO:0019213 ! deacetylase activity created_by: BarbaraCzub creation_date: 2018-07-23T12:37:57Z [Term] id: GO:0150067 name: regulation of tubulin deacetylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] is_a: GO:0090043 ! regulation of tubulin deacetylation is_a: GO:0150065 ! regulation of deacetylase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042903 ! tubulin deacetylase activity relationship: regulates GO:0042903 ! tubulin deacetylase activity created_by: BarbaraCzub creation_date: 2018-07-24T10:29:49Z [Term] id: GO:0150068 name: positive regulation of tubulin deacetylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc] is_a: GO:0090044 ! positive regulation of tubulin deacetylation is_a: GO:0090045 ! positive regulation of deacetylase activity is_a: GO:0150067 ! regulation of tubulin deacetylase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042903 ! tubulin deacetylase activity relationship: positively_regulates GO:0042903 ! tubulin deacetylase activity created_by: BarbaraCzub creation_date: 2018-07-24T10:35:51Z [Term] id: GO:0150069 name: negative regulation of tubulin deacetylase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] is_a: GO:0150066 ! negative regulation of deacetylase activity is_a: GO:0150067 ! regulation of tubulin deacetylase activity is_a: GO:1904428 ! negative regulation of tubulin deacetylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042903 ! tubulin deacetylase activity relationship: negatively_regulates GO:0042903 ! tubulin deacetylase activity created_by: BarbaraCzub creation_date: 2018-07-24T10:40:19Z [Term] id: GO:0150070 name: regulation of arginase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004053 ! arginase activity relationship: regulates GO:0004053 ! arginase activity created_by: BarbaraCzub creation_date: 2018-07-25T09:17:30Z [Term] id: GO:0150071 name: negative regulation of arginase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0150070 ! regulation of arginase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004053 ! arginase activity relationship: negatively_regulates GO:0004053 ! arginase activity created_by: BarbaraCzub creation_date: 2018-07-25T09:22:32Z [Term] id: GO:0150072 name: positive regulation of arginase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0150070 ! regulation of arginase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004053 ! arginase activity relationship: positively_regulates GO:0004053 ! arginase activity created_by: BarbaraCzub creation_date: 2018-07-25T09:26:20Z [Term] id: GO:0150073 name: regulation of protein-glutamine gamma-glutamyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity relationship: regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity created_by: BarbaraCzub creation_date: 2018-07-25T10:03:10Z [Term] id: GO:0150074 name: positive regulation of protein-glutamine gamma-glutamyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity relationship: positively_regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity created_by: BarbaraCzub creation_date: 2018-07-25T10:08:19Z [Term] id: GO:0150075 name: negative regulation of protein-glutamine gamma-glutamyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity relationship: negatively_regulates GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity created_by: BarbaraCzub creation_date: 2018-07-25T10:10:24Z [Term] id: GO:0150076 name: neuroinflammatory response namespace: biological_process def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] synonym: "nerve tissue inflammatory response" EXACT [] synonym: "nervous tissue inflammatory response" EXACT [] synonym: "neural tissue inflammatory response" EXACT [] is_a: GO:0006954 ! inflammatory response created_by: BarbaraCzub creation_date: 2018-07-26T12:25:34Z [Term] id: GO:0150077 name: regulation of neuroinflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150076 ! neuroinflammatory response relationship: regulates GO:0150076 ! neuroinflammatory response created_by: BarbaraCzub creation_date: 2018-07-26T12:32:18Z [Term] id: GO:0150078 name: positive regulation of neuroinflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150076 ! neuroinflammatory response relationship: positively_regulates GO:0150076 ! neuroinflammatory response created_by: BarbaraCzub creation_date: 2018-07-26T12:35:50Z [Term] id: GO:0150079 name: negative regulation of neuroinflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150076 ! neuroinflammatory response relationship: negatively_regulates GO:0150076 ! neuroinflammatory response created_by: BarbaraCzub creation_date: 2018-07-26T12:38:08Z [Term] id: GO:0150086 name: multiple synapse bouton namespace: cellular_component def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344] synonym: "MSB" EXACT [] synonym: "multi-synapse" RELATED [] synonym: "multi-synapse bouton" EXACT [] synonym: "multi-synaptic bouton" EXACT [] synonym: "multiple spine synapse bouton" EXACT [] synonym: "multiple synapse" RELATED [] synonym: "multiple-synapse bouton" EXACT [] synonym: "multisynapse" RELATED [] synonym: "multisynapse bouton" EXACT [] synonym: "multisynaptic bouton" EXACT [] is_a: GO:0043195 ! terminal bouton created_by: BarbaraCzub creation_date: 2018-08-08T13:21:17Z [Term] id: GO:0150087 name: multiple synapse bouton, contacting single dendrite namespace: cellular_component def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234] synonym: "MSB1" EXACT [PMID:24487234] synonym: "type 1 multi-synapse bouton" EXACT [PMID:24487234] synonym: "type 1 multi-synaptic bouton" EXACT [PMID:24487234] synonym: "type 1 multiple spine synapse bouton" EXACT [PMID:24487234] synonym: "type 1 multiple-synapse bouton" EXACT [PMID:24487234] synonym: "type 1 multisynapse bouton" EXACT [PMID:24487234] synonym: "type 1 multisynaptic bouton" EXACT [PMID:24487234] is_a: GO:0150086 ! multiple synapse bouton created_by: BarbaraCzub creation_date: 2018-08-08T13:26:34Z [Term] id: GO:0150088 name: multiple synapse bouton, contacting multiple dendrites namespace: cellular_component def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344] synonym: "MSB2" EXACT [PMID:24487234] synonym: "type 2 multi-synapse bouton" EXACT [PMID:24487234] synonym: "type 2 multi-synaptic bouton" EXACT [PMID:24487234] synonym: "type 2 multiple spine synapse bouton" EXACT [PMID:24487234] synonym: "type 2 multiple-synapse bouton" EXACT [PMID:24487234] synonym: "type 2 multisynapse bouton" EXACT [PMID:24487234] synonym: "type 2 multisynaptic bouton" EXACT [PMID:24487234] is_a: GO:0150086 ! multiple synapse bouton created_by: BarbaraCzub creation_date: 2018-08-08T13:31:43Z [Term] id: GO:0150089 name: multiple spine synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344] synonym: "multi-synapse organisation" BROAD [] synonym: "multi-synapse organization" BROAD [] synonym: "multi-synaptic organisation" BROAD [] synonym: "multi-synaptic organization" BROAD [] synonym: "multiple spine synapse organisation" EXACT [] synonym: "multisynapse organisation" BROAD [] synonym: "multisynapse organization" BROAD [] synonym: "multisynaptic organisation" BROAD [] synonym: "multisynaptic organization" BROAD [] is_a: GO:0050808 ! synapse organization created_by: BarbaraCzub creation_date: 2018-08-08T14:54:50Z [Term] id: GO:0150090 name: multiple spine synapse organization, single dendrite namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234] is_a: GO:0150089 ! multiple spine synapse organization created_by: BarbaraCzub creation_date: 2018-08-08T14:59:49Z [Term] id: GO:0150091 name: multiple spine synapse organization, multiple dendrites namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344] is_a: GO:0150089 ! multiple spine synapse organization created_by: BarbaraCzub creation_date: 2018-08-08T15:05:29Z [Term] id: GO:0150092 name: regulation of synaptic scaling namespace: biological_process def: "A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell." [GOC:aruk, GOC:bc, PMID:14630218, PMID:14735113, PMID:16547515] synonym: "homeostatic synaptic scaling" RELATED [PMID:16547515] synonym: "regulation of homeostatic synaptic scaling" RELATED [] is_a: GO:0048167 ! regulation of synaptic plasticity created_by: BarbaraCzub creation_date: 2018-08-09T16:27:28Z [Term] id: GO:0150093 name: amyloid-beta clearance by transcytosis namespace: biological_process def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:26005850] is_a: GO:0045056 ! transcytosis is_a: GO:0097242 ! amyloid-beta clearance created_by: BarbaraCzub creation_date: 2018-08-16T14:33:47Z [Term] id: GO:0150094 name: amyloid-beta clearance by cellular catabolic process namespace: biological_process def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation." [GOC:aruk, GOC:bc, PMID:18289866] synonym: "amyloid-beta clearance by phagocytosis" NARROW [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0097242 ! amyloid-beta clearance created_by: BarbaraCzub creation_date: 2018-08-16T14:38:09Z [Term] id: GO:0150098 name: glial cell-neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] synonym: "glia-neuron signaling" EXACT [] synonym: "glia-neuron signalling" EXACT [] synonym: "glia-neurone signaling" EXACT [] synonym: "glia-neurone signalling" EXACT [] synonym: "glial cell- neuron signalling" EXACT [] synonym: "glial cell-neurone signalling" EXACT [] synonym: "glial cell-neurone singaling" EXACT [] is_a: GO:0007267 ! cell-cell signaling created_by: BarbaraCzub creation_date: 2018-12-17T12:28:09Z [Term] id: GO:0150099 name: neuron-glial cell signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] synonym: "neuron-glia signaling" EXACT [] synonym: "neuron-glia signalling" EXACT [] synonym: "neuron-glial cell signalling" EXACT [] synonym: "neurone-glia signaling" EXACT [] synonym: "neurone-glia signalling" EXACT [] synonym: "neurone-glial cell signaling" EXACT [] synonym: "neurone-glial cell signalling" EXACT [] is_a: GO:0007267 ! cell-cell signaling created_by: BarbaraCzub creation_date: 2018-12-17T12:30:12Z [Term] id: GO:0150100 name: RNA binding involved in posttranscriptional gene silencing namespace: molecular_function def: "Any RNA binding that is involved in posttranscriptional gene silencing." [GOC:aruk, GOC:bc, GOC:rl, PMID:23985560, PMID:28379604] synonym: "RNA binding involved in cosuppression" RELATED [] synonym: "RNA binding involved in post-transcriptional gene silencing" EXACT [] synonym: "RNA binding involved in PTGS" EXACT [] synonym: "RNA binding involved in quelling" EXACT [] is_a: GO:0003723 ! RNA binding intersection_of: GO:0003723 ! RNA binding intersection_of: part_of GO:0016441 ! posttranscriptional gene silencing relationship: part_of GO:0016441 ! posttranscriptional gene silencing created_by: BarbaraCzub creation_date: 2019-03-11T11:48:27Z [Term] id: GO:0150101 name: regulation of microtubule anchoring at centrosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome." [GOC:aruk, GOC:bc, PMID:17139249] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034454 ! microtubule anchoring at centrosome relationship: regulates GO:0034454 ! microtubule anchoring at centrosome created_by: BarbaraCzub creation_date: 2019-04-17T11:24:52Z [Term] id: GO:0150102 name: negative regulation of monocyte activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323] synonym: "repression of monocyte activation" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042117 ! monocyte activation relationship: regulates GO:0042117 ! monocyte activation created_by: BarbaraCzub creation_date: 2019-04-26T20:01:24Z [Term] id: GO:0150103 name: reactive gliosis namespace: biological_process def: "A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells." [GOC:aruk, GOC:bc, PMID:24462092] synonym: "gliosis" BROAD [] is_a: GO:0150076 ! neuroinflammatory response created_by: BarbaraCzub creation_date: 2019-05-21T12:37:31Z [Term] id: GO:0150104 name: transport across blood-brain barrier namespace: biological_process def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008] synonym: "transport across BBB" EXACT [] synonym: "transport across blood brain barrier" EXACT [] is_a: GO:0006810 ! transport created_by: BarbaraCzub creation_date: 2019-05-27T09:12:03Z [Term] id: GO:0150105 name: protein localization to cell-cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:1902414 ! protein localization to cell junction created_by: BarbaraCzub creation_date: 2019-06-11T11:00:18Z [Term] id: GO:0150106 name: regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150105 ! protein localization to cell-cell junction relationship: regulates GO:0150105 ! protein localization to cell-cell junction created_by: BarbaraCzub creation_date: 2019-06-11T11:17:15Z [Term] id: GO:0150107 name: positive regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0150106 ! regulation of protein localization to cell-cell junction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150105 ! protein localization to cell-cell junction relationship: positively_regulates GO:0150105 ! protein localization to cell-cell junction created_by: BarbaraCzub creation_date: 2019-06-11T11:23:58Z [Term] id: GO:0150110 name: negative regulation of cholesterol esterification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification." [GOC:aruk, GOC:bc, PMID:21810484, PMID:24201375] is_a: GO:0010872 ! regulation of cholesterol esterification is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034435 ! cholesterol esterification relationship: negatively_regulates GO:0034435 ! cholesterol esterification created_by: BarbaraCzub creation_date: 2019-07-23T15:34:42Z [Term] id: GO:0150111 name: regulation of transepithelial transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070633 ! transepithelial transport relationship: regulates GO:0070633 ! transepithelial transport created_by: BarbaraCzub creation_date: 2019-09-15T07:16:49Z [Term] id: GO:0150112 name: regulation of interleukin-7 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782] is_a: GO:0032676 ! regulation of interleukin-7 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072605 ! interleukin-7 secretion relationship: regulates GO:0072605 ! interleukin-7 secretion created_by: BarbaraCzub creation_date: 2019-10-27T08:50:42Z [Term] id: GO:0150113 name: negative regulation of interleukin-7 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782] is_a: GO:0032716 ! negative regulation of interleukin-7 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0150112 ! regulation of interleukin-7 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072605 ! interleukin-7 secretion relationship: negatively_regulates GO:0072605 ! interleukin-7 secretion created_by: BarbaraCzub creation_date: 2019-10-27T08:53:35Z [Term] id: GO:0150114 name: positive regulation of interleukin-7 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk] is_a: GO:0032756 ! positive regulation of interleukin-7 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0150112 ! regulation of interleukin-7 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072605 ! interleukin-7 secretion relationship: positively_regulates GO:0072605 ! interleukin-7 secretion created_by: BarbaraCzub creation_date: 2019-10-27T08:55:49Z [Term] id: GO:0150115 name: cell-substrate junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] is_a: GO:0034330 ! cell junction organization created_by: BarbaraCzub creation_date: 2019-11-14T11:06:29Z [Term] id: GO:0150116 name: regulation of cell-substrate junction organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150115 ! cell-substrate junction organization relationship: regulates GO:0150115 ! cell-substrate junction organization created_by: BarbaraCzub creation_date: 2019-11-14T12:12:27Z [Term] id: GO:0150117 name: positive regulation of cell-substrate junction organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0150116 ! regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150115 ! cell-substrate junction organization relationship: positively_regulates GO:0150115 ! cell-substrate junction organization created_by: BarbaraCzub creation_date: 2019-11-14T12:15:07Z [Term] id: GO:0150118 name: negative regulation of cell-substrate junction organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0150116 ! regulation of cell-substrate junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150115 ! cell-substrate junction organization relationship: negatively_regulates GO:0150115 ! cell-substrate junction organization created_by: BarbaraCzub creation_date: 2019-11-14T12:16:32Z [Term] id: GO:0150119 name: negative regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc] synonym: "negative regulation of protein localisation to cell-cell junction" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0150106 ! regulation of protein localization to cell-cell junction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150105 ! protein localization to cell-cell junction relationship: negatively_regulates GO:0150105 ! protein localization to cell-cell junction created_by: BarbaraCzub creation_date: 2019-11-21T13:53:34Z [Term] id: GO:0150120 name: regulation of interleukin-18 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316] is_a: GO:0032661 ! regulation of interleukin-18 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072616 ! interleukin-18 secretion relationship: regulates GO:0072616 ! interleukin-18 secretion created_by: BarbaraCzub creation_date: 2019-11-27T11:37:50Z [Term] id: GO:0150121 name: negative regulation of interleukin-18 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316] is_a: GO:0032701 ! negative regulation of interleukin-18 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0150120 ! regulation of interleukin-18 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072616 ! interleukin-18 secretion relationship: negatively_regulates GO:0072616 ! interleukin-18 secretion created_by: BarbaraCzub creation_date: 2019-11-27T11:40:37Z [Term] id: GO:0150122 name: positive regulation of interleukin-18 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk] is_a: GO:0032741 ! positive regulation of interleukin-18 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0150120 ! regulation of interleukin-18 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072616 ! interleukin-18 secretion relationship: positively_regulates GO:0072616 ! interleukin-18 secretion created_by: BarbaraCzub creation_date: 2019-11-27T11:44:29Z [Term] id: GO:0150123 name: regulation of interleukin-33 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524] is_a: GO:0042035 ! regulation of cytokine biosynthetic process is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150126 ! interleukin-33 biosynthetic process relationship: regulates GO:0150126 ! interleukin-33 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-01T16:39:17Z [Term] id: GO:0150124 name: negative regulation of interleukin-33 biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process is_a: GO:0150128 ! negative regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process relationship: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-01T16:39:36Z [Term] id: GO:0150125 name: positive regulation of interleukin-33 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process is_a: GO:0150129 ! positive regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process relationship: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-01T16:39:45Z [Term] id: GO:0150126 name: interleukin-33 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-33." [GOC:aruk, PMID:29778524] is_a: GO:0042089 ! cytokine biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process relationship: part_of GO:0072639 ! interleukin-33 production created_by: BarbaraCzub creation_date: 2019-12-01T16:46:17Z [Term] id: GO:0150127 name: regulation of interleukin-33 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072639 ! interleukin-33 production relationship: regulates GO:0072639 ! interleukin-33 production created_by: BarbaraCzub creation_date: 2019-12-01T17:05:01Z [Term] id: GO:0150128 name: negative regulation of interleukin-33 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072639 ! interleukin-33 production relationship: negatively_regulates GO:0072639 ! interleukin-33 production created_by: BarbaraCzub creation_date: 2019-12-01T17:08:31Z [Term] id: GO:0150129 name: positive regulation of interleukin-33 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 production." [GOC:aruk] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072639 ! interleukin-33 production relationship: positively_regulates GO:0072639 ! interleukin-33 production created_by: BarbaraCzub creation_date: 2019-12-01T17:10:56Z [Term] id: GO:0150130 name: regulation of interleukin-33 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524] is_a: GO:0050707 ! regulation of cytokine secretion is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072640 ! interleukin-33 secretion relationship: regulates GO:0072640 ! interleukin-33 secretion created_by: BarbaraCzub creation_date: 2019-12-03T05:54:03Z [Term] id: GO:0150131 name: negative regulation of interleukin-33 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0150128 ! negative regulation of interleukin-33 production is_a: GO:0150130 ! regulation of interleukin-33 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072640 ! interleukin-33 secretion relationship: negatively_regulates GO:0072640 ! interleukin-33 secretion created_by: BarbaraCzub creation_date: 2019-12-03T05:54:24Z [Term] id: GO:0150132 name: positive regulation of interleukin-33 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0150129 ! positive regulation of interleukin-33 production is_a: GO:0150130 ! regulation of interleukin-33 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072640 ! interleukin-33 secretion relationship: positively_regulates GO:0072640 ! interleukin-33 secretion created_by: BarbaraCzub creation_date: 2019-12-03T05:54:37Z [Term] id: GO:0150133 name: regulation of interleukin-4 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524] is_a: GO:0032673 ! regulation of interleukin-4 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072602 ! interleukin-4 secretion relationship: regulates GO:0072602 ! interleukin-4 secretion created_by: BarbaraCzub creation_date: 2019-12-03T11:33:28Z [Term] id: GO:0150134 name: negative regulation of interleukin-4 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524] is_a: GO:0032713 ! negative regulation of interleukin-4 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0150133 ! regulation of interleukin-4 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072602 ! interleukin-4 secretion relationship: negatively_regulates GO:0072602 ! interleukin-4 secretion created_by: BarbaraCzub creation_date: 2019-12-03T11:33:56Z [Term] id: GO:0150135 name: positive regulation of interleukin-4 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk] is_a: GO:0032753 ! positive regulation of interleukin-4 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0150133 ! regulation of interleukin-4 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072602 ! interleukin-4 secretion relationship: positively_regulates GO:0072602 ! interleukin-4 secretion created_by: BarbaraCzub creation_date: 2019-12-03T11:35:42Z [Term] id: GO:0150136 name: regulation of interleukin-37 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558] is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150137 ! interleukin-37 biosynthetic process relationship: regulates GO:0150137 ! interleukin-37 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T08:39:07Z [Term] id: GO:0150137 name: interleukin-37 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-37." [GOC:aruk, PMID:30362558] is_a: GO:0042089 ! cytokine biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T08:43:09Z [Term] id: GO:0150138 name: negative regulation of interleukin-37 biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process relationship: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T08:45:29Z [Term] id: GO:0150139 name: positive regulation of interleukin-37 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process relationship: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T08:47:29Z [Term] id: GO:0150140 name: regulation of CD86 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035781 ! CD86 biosynthetic process relationship: regulates GO:0035781 ! CD86 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T09:31:00Z [Term] id: GO:0150141 name: negative regulation of CD86 biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0150140 ! regulation of CD86 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035781 ! CD86 biosynthetic process relationship: negatively_regulates GO:0035781 ! CD86 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T09:33:39Z [Term] id: GO:0150142 name: positive regulation of CD86 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0150140 ! regulation of CD86 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035781 ! CD86 biosynthetic process relationship: positively_regulates GO:0035781 ! CD86 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T09:35:35Z [Term] id: GO:0150143 name: regulation of CD80 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035780 ! CD80 biosynthetic process relationship: regulates GO:0035780 ! CD80 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T10:23:43Z [Term] id: GO:0150144 name: negative regulation of CD80 biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process is_a: GO:0150143 ! regulation of CD80 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035780 ! CD80 biosynthetic process relationship: negatively_regulates GO:0035780 ! CD80 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T10:26:42Z [Term] id: GO:0150145 name: positive regulation of CD80 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:0150143 ! regulation of CD80 biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035780 ! CD80 biosynthetic process relationship: positively_regulates GO:0035780 ! CD80 biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-08T10:29:00Z [Term] id: GO:0150146 name: cell junction disassembly namespace: biological_process def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0034330 ! cell junction organization created_by: BarbaraCzub creation_date: 2019-12-08T11:12:13Z [Term] id: GO:0150147 name: cell-cell junction disassembly namespace: biological_process def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0045216 ! cell-cell junction organization is_a: GO:0150146 ! cell junction disassembly created_by: BarbaraCzub creation_date: 2019-12-08T11:16:14Z [Term] id: GO:0150148 name: regulation of interleukin-25 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018] is_a: GO:0032669 ! regulation of interleukin-25 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072623 ! interleukin-25 secretion relationship: regulates GO:0072623 ! interleukin-25 secretion created_by: BarbaraCzub creation_date: 2019-12-09T16:51:07Z [Term] id: GO:0150149 name: negative regulation of interleukin-25 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018] is_a: GO:0032709 ! negative regulation of interleukin-25 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:0150148 ! regulation of interleukin-25 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072623 ! interleukin-25 secretion relationship: negatively_regulates GO:0072623 ! interleukin-25 secretion created_by: BarbaraCzub creation_date: 2019-12-09T16:51:28Z [Term] id: GO:0150150 name: positive regulation of interleukin-25 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk] is_a: GO:0032749 ! positive regulation of interleukin-25 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:0150148 ! regulation of interleukin-25 secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072623 ! interleukin-25 secretion relationship: positively_regulates GO:0072623 ! interleukin-25 secretion created_by: BarbaraCzub creation_date: 2019-12-09T16:51:44Z [Term] id: GO:0150151 name: regulation of interleukin-17A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018] is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150154 ! interleukin-17A biosynthetic process relationship: regulates GO:0150154 ! interleukin-17A biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-11T07:44:52Z [Term] id: GO:0150152 name: negative regulation of interleukin-17A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018] is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process relationship: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-11T07:45:24Z [Term] id: GO:0150153 name: positive regulation of interleukin-17A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk] is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process relationship: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-11T07:45:44Z [Term] id: GO:0150154 name: interleukin-17A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of interleukin-17A." [GOC:aruk, PMID:27901018] is_a: GO:0042089 ! cytokine biosynthetic process created_by: BarbaraCzub creation_date: 2019-12-11T07:55:52Z [Term] id: GO:0198738 name: cell-cell signaling by wnt namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell." [GOC:dos] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:1900000 name: regulation of anthocyanin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] synonym: "regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] synonym: "regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] synonym: "regulation of anthocyanin degradation" EXACT [GOC:TermGenie] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046284 ! anthocyanin-containing compound catabolic process relationship: regulates GO:0046284 ! anthocyanin-containing compound catabolic process created_by: tb creation_date: 2011-12-20T07:12:07Z [Term] id: GO:1900001 name: negative regulation of anthocyanin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] synonym: "down regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of anthocyanin degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of anthocyanin degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process is_a: GO:1900000 ! regulation of anthocyanin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process relationship: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process created_by: tb creation_date: 2011-12-20T07:12:11Z [Term] id: GO:1900002 name: positive regulation of anthocyanin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] synonym: "positive regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of anthocyanin degradation" EXACT [GOC:TermGenie] synonym: "up regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of anthocyanin degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process is_a: GO:1900000 ! regulation of anthocyanin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process relationship: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process created_by: tb creation_date: 2011-12-20T07:12:15Z [Term] id: GO:1900003 name: regulation of serine-type endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] synonym: "regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] is_a: GO:0052548 ! regulation of endopeptidase activity is_a: GO:1902571 ! regulation of serine-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004252 ! serine-type endopeptidase activity relationship: regulates GO:0004252 ! serine-type endopeptidase activity created_by: kmv creation_date: 2012-01-09T10:03:15Z [Term] id: GO:1900004 name: negative regulation of serine-type endopeptidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] synonym: "down regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] synonym: "down regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:1900003 ! regulation of serine-type endopeptidase activity is_a: GO:1902572 ! negative regulation of serine-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004252 ! serine-type endopeptidase activity relationship: negatively_regulates GO:0004252 ! serine-type endopeptidase activity created_by: kmv creation_date: 2012-01-09T10:03:20Z [Term] id: GO:1900005 name: positive regulation of serine-type endopeptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] synonym: "positive regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] synonym: "up regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] synonym: "up regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie] is_a: GO:0010950 ! positive regulation of endopeptidase activity is_a: GO:1900003 ! regulation of serine-type endopeptidase activity is_a: GO:1902573 ! positive regulation of serine-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004252 ! serine-type endopeptidase activity relationship: positively_regulates GO:0004252 ! serine-type endopeptidase activity created_by: kmv creation_date: 2012-01-09T10:03:29Z [Term] id: GO:1900006 name: positive regulation of dendrite development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie] synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016358 ! dendrite development relationship: positively_regulates GO:0016358 ! dendrite development created_by: hjd creation_date: 2012-01-09T10:41:31Z [Term] id: GO:1900007 name: regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] is_a: GO:1900062 ! regulation of replicative cell aging is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging relationship: regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging created_by: se creation_date: 2012-01-09T10:44:07Z [Term] id: GO:1900008 name: negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie] synonym: "down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] is_a: GO:0090344 ! negative regulation of cell aging is_a: GO:1900007 ! regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging relationship: negatively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging created_by: se creation_date: 2012-01-09T10:44:10Z [Term] id: GO:1900009 name: positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] synonym: "up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie] synonym: "up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] is_a: GO:0090343 ! positive regulation of cell aging is_a: GO:1900007 ! regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging relationship: positively_regulates GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging created_by: se creation_date: 2012-01-09T10:44:18Z [Term] id: GO:1900010 name: regulation of corticotropin-releasing hormone receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] synonym: "regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] synonym: "regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] synonym: "regulation of CRF receptor activity" EXACT [GOC:TermGenie] synonym: "regulation of CRH receptor activity" EXACT [GOC:TermGenie] is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043404 ! corticotropin-releasing hormone receptor activity relationship: regulates GO:0043404 ! corticotropin-releasing hormone receptor activity created_by: pr creation_date: 2012-01-10T02:27:23Z [Term] id: GO:1900011 name: negative regulation of corticotropin-releasing hormone receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] synonym: "down regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie] synonym: "down regulation of CRF receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of CRH receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CRF receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CRH receptor activity" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity relationship: negatively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity created_by: pr creation_date: 2012-01-10T02:27:27Z [Term] id: GO:1900012 name: positive regulation of corticotropin-releasing hormone receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] synonym: "positive regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CRF receptor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CRH receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie] synonym: "up regulation of CRF receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of CRH receptor activity" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity relationship: positively_regulates GO:0043404 ! corticotropin-releasing hormone receptor activity created_by: pr creation_date: 2012-01-10T02:27:30Z [Term] id: GO:1900013 name: obsolete cellular response to potassium ion involved in chemotaxis to cAMP namespace: biological_process def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624] comment: This term was made obsolete because it was added by mistake. synonym: "cellular response to K+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to K+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to K+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] synonym: "cellular response to K+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to K+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] synonym: "cellular response to potassium ion involved in chemotaxis to cAMP" EXACT [] synonym: "cellular response to potassium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to potassium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to potassium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie] synonym: "cellular response to potassium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to potassium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie] synonym: "cellular response to potassium of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to potassium of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to potassium of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] synonym: "cellular response to potassium of chemotaxis to cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to potassium of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2012-01-11T07:59:57Z [Term] id: GO:1900014 name: obsolete cellular response to calcium ion involved in chemotaxis to cAMP namespace: biological_process def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624, PMID:8937985] synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] synonym: "cellular response to Ca2+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] synonym: "cellular response to Ca2+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to Ca2+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] synonym: "cellular response to calcium ion involved in chemotaxis to cAMP" EXACT [] synonym: "cellular response to calcium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to calcium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to calcium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie] synonym: "cellular response to calcium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] synonym: "cellular response to calcium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2012-01-11T08:06:58Z [Term] id: GO:1900015 name: regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002534 ! cytokine production involved in inflammatory response relationship: regulates GO:0002534 ! cytokine production involved in inflammatory response created_by: rph creation_date: 2012-01-11T09:34:27Z [Term] id: GO:1900016 name: negative regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response relationship: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response created_by: rph creation_date: 2012-01-11T09:34:31Z [Term] id: GO:1900017 name: positive regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response relationship: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response created_by: rph creation_date: 2012-01-11T09:34:35Z [Term] id: GO:1900018 name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex namespace: biological_process def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex." [GOC:rb, GOC:TermGenie, PMID:10594013, PMID:19666497] is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues intersection_of: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues intersection_of: part_of GO:0036031 ! recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex relationship: part_of GO:0036031 ! recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex created_by: bf creation_date: 2012-01-11T11:40:41Z [Term] id: GO:1900019 name: regulation of protein kinase C activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie] synonym: "regulation of PKC" RELATED [GOC:TermGenie] synonym: "regulation of PKC activity" EXACT [GOC:TermGenie] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004697 ! protein kinase C activity relationship: regulates GO:0004697 ! protein kinase C activity created_by: bf creation_date: 2012-01-11T03:50:47Z [Term] id: GO:1900020 name: positive regulation of protein kinase C activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie] synonym: "positive regulation of PKC" RELATED [GOC:TermGenie] synonym: "positive regulation of PKC activity" EXACT [GOC:TermGenie] synonym: "up regulation of PKC" RELATED [GOC:TermGenie] synonym: "up regulation of PKC activity" EXACT [GOC:TermGenie] is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity is_a: GO:1900019 ! regulation of protein kinase C activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004697 ! protein kinase C activity relationship: positively_regulates GO:0004697 ! protein kinase C activity created_by: bf creation_date: 2012-01-11T03:50:55Z [Term] id: GO:1900022 name: regulation of D-erythro-sphingosine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie] synonym: "regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017050 ! D-erythro-sphingosine kinase activity relationship: regulates GO:0017050 ! D-erythro-sphingosine kinase activity created_by: bf creation_date: 2012-01-11T04:30:29Z [Term] id: GO:1900023 name: positive regulation of D-erythro-sphingosine kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie] synonym: "positive regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of D-erythro-sphingosine kinase activity" RELATED [GOC:TermGenie] synonym: "up regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:1900022 ! regulation of D-erythro-sphingosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017050 ! D-erythro-sphingosine kinase activity relationship: positively_regulates GO:0017050 ! D-erythro-sphingosine kinase activity created_by: bf creation_date: 2012-01-11T04:30:33Z [Term] id: GO:1900024 name: regulation of substrate adhesion-dependent cell spreading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] synonym: "regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] synonym: "regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0010810 ! regulation of cell-substrate adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034446 ! substrate adhesion-dependent cell spreading relationship: regulates GO:0034446 ! substrate adhesion-dependent cell spreading created_by: yaf creation_date: 2012-01-12T05:00:39Z [Term] id: GO:1900025 name: negative regulation of substrate adhesion-dependent cell spreading namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] synonym: "down regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie] synonym: "negative regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] synonym: "negative regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:0010812 ! negative regulation of cell-substrate adhesion is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading relationship: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading created_by: yaf creation_date: 2012-01-12T05:00:43Z [Term] id: GO:1900026 name: positive regulation of substrate adhesion-dependent cell spreading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] synonym: "positive regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] synonym: "positive regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] synonym: "up regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] synonym: "up regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0010811 ! positive regulation of cell-substrate adhesion is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading relationship: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading created_by: yaf creation_date: 2012-01-12T05:00:46Z [Term] id: GO:1900027 name: regulation of ruffle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] synonym: "regulation of membrane ruffle formation" EXACT [GOC:TermGenie] synonym: "regulation of membrane ruffling" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097178 ! ruffle assembly relationship: regulates GO:0097178 ! ruffle assembly created_by: yaf creation_date: 2012-01-12T05:00:49Z [Term] id: GO:1900028 name: negative regulation of ruffle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of membrane ruffle formation" EXACT [GOC:TermGenie] synonym: "down regulation of membrane ruffling" EXACT [GOC:TermGenie] synonym: "down regulation of ruffle assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of membrane ruffle formation" EXACT [GOC:TermGenie] synonym: "negative regulation of membrane ruffling" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1900027 ! regulation of ruffle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097178 ! ruffle assembly relationship: negatively_regulates GO:0097178 ! ruffle assembly created_by: yaf creation_date: 2012-01-12T05:00:53Z [Term] id: GO:1900029 name: positive regulation of ruffle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] synonym: "positive regulation of membrane ruffle formation" EXACT [GOC:TermGenie] synonym: "positive regulation of membrane ruffling" EXACT [GOC:TermGenie] synonym: "up regulation of membrane ruffle formation" EXACT [GOC:TermGenie] synonym: "up regulation of membrane ruffling" EXACT [GOC:TermGenie] synonym: "up regulation of ruffle assembly" RELATED [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1900027 ! regulation of ruffle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097178 ! ruffle assembly relationship: positively_regulates GO:0097178 ! ruffle assembly created_by: yaf creation_date: 2012-01-12T05:00:56Z [Term] id: GO:1900030 name: regulation of pectin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pectin biosynthetic process." [GOC:TermGenie] synonym: "regulation of pectin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of pectin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of pectin formation" EXACT [GOC:TermGenie] synonym: "regulation of pectin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045489 ! pectin biosynthetic process relationship: regulates GO:0045489 ! pectin biosynthetic process created_by: tb creation_date: 2012-01-13T02:03:37Z [Term] id: GO:1900031 name: obsolete regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling namespace: biological_process def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036] synonym: "global transcription regulation from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signalling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signalling" RELATED [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-01-13T04:09:19Z [Term] id: GO:1900032 name: regulation of trichome patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trichome patterning." [GOC:TermGenie] synonym: "regulation of trichome distribution" BROAD [GOC:TermGenie] synonym: "regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "regulation of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "regulation of trichome spacing" EXACT [GOC:TermGenie] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048629 ! trichome patterning relationship: regulates GO:0048629 ! trichome patterning created_by: tb creation_date: 2012-01-13T11:10:46Z [Term] id: GO:1900033 name: negative regulation of trichome patterning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning." [GOC:TermGenie] synonym: "down regulation of trichome distribution" BROAD [GOC:TermGenie] synonym: "down regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "down regulation of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "down regulation of trichome patterning" RELATED [GOC:TermGenie] synonym: "down regulation of trichome spacing" EXACT [GOC:TermGenie] synonym: "down-regulation of trichome distribution" BROAD [GOC:TermGenie] synonym: "down-regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "down-regulation of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "down-regulation of trichome patterning" RELATED [GOC:TermGenie] synonym: "down-regulation of trichome spacing" EXACT [GOC:TermGenie] synonym: "downregulation of trichome distribution" BROAD [GOC:TermGenie] synonym: "downregulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "downregulation of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "downregulation of trichome patterning" RELATED [GOC:TermGenie] synonym: "downregulation of trichome spacing" EXACT [GOC:TermGenie] synonym: "inhibition of trichome distribution" BROAD [GOC:TermGenie] synonym: "inhibition of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "inhibition of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "inhibition of trichome patterning" RELATED [GOC:TermGenie] synonym: "inhibition of trichome spacing" EXACT [GOC:TermGenie] synonym: "negative regulation of trichome distribution" BROAD [GOC:TermGenie] synonym: "negative regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of trichome pattern formation" EXACT [GOC:TermGenie] synonym: "negative regulation of trichome pattern specification" RELATED [GOC:TermGenie] synonym: "negative regulation of trichome spacing" EXACT [GOC:TermGenie] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1900032 ! regulation of trichome patterning intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048629 ! trichome patterning relationship: negatively_regulates GO:0048629 ! trichome patterning created_by: tb creation_date: 2012-01-13T11:10:50Z [Term] id: GO:1900034 name: regulation of cellular response to heat namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] synonym: "regulation of cellular response to heat stress" EXACT [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034605 ! cellular response to heat relationship: regulates GO:0034605 ! cellular response to heat created_by: yaf creation_date: 2012-01-17T09:27:40Z [Term] id: GO:1900035 name: negative regulation of cellular response to heat namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to heat" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to heat stress" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900034 ! regulation of cellular response to heat intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034605 ! cellular response to heat relationship: negatively_regulates GO:0034605 ! cellular response to heat created_by: yaf creation_date: 2012-01-17T09:27:44Z [Term] id: GO:1900036 name: positive regulation of cellular response to heat namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "activation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to heat stress" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to heat" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to heat stress" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900034 ! regulation of cellular response to heat intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034605 ! cellular response to heat relationship: positively_regulates GO:0034605 ! cellular response to heat created_by: yaf creation_date: 2012-01-17T09:27:47Z [Term] id: GO:1900037 name: regulation of cellular response to hypoxia namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] synonym: "regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071456 ! cellular response to hypoxia relationship: regulates GO:0071456 ! cellular response to hypoxia created_by: yaf creation_date: 2012-01-17T09:29:03Z [Term] id: GO:1900038 name: negative regulation of cellular response to hypoxia namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900037 ! regulation of cellular response to hypoxia intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071456 ! cellular response to hypoxia relationship: negatively_regulates GO:0071456 ! cellular response to hypoxia created_by: yaf creation_date: 2012-01-17T09:29:16Z [Term] id: GO:1900039 name: positive regulation of cellular response to hypoxia namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "activation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "activation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to hypoxia" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900037 ! regulation of cellular response to hypoxia intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071456 ! cellular response to hypoxia relationship: positively_regulates GO:0071456 ! cellular response to hypoxia created_by: yaf creation_date: 2012-01-17T09:29:19Z [Term] id: GO:1900040 name: regulation of interleukin-2 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] synonym: "regulation of IL-2 secretion" EXACT [GOC:TermGenie] is_a: GO:0032663 ! regulation of interleukin-2 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070970 ! interleukin-2 secretion relationship: regulates GO:0070970 ! interleukin-2 secretion created_by: yaf creation_date: 2012-01-17T11:20:57Z [Term] id: GO:1900041 name: negative regulation of interleukin-2 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "down-regulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "downregulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "inhibition of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "inhibition of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "negative regulation of IL-2 secretion" EXACT [GOC:TermGenie] is_a: GO:0032703 ! negative regulation of interleukin-2 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1900040 ! regulation of interleukin-2 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070970 ! interleukin-2 secretion relationship: negatively_regulates GO:0070970 ! interleukin-2 secretion created_by: yaf creation_date: 2012-01-17T11:21:06Z [Term] id: GO:1900042 name: positive regulation of interleukin-2 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] synonym: "activation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "activation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "positive regulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "up-regulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] synonym: "upregulation of IL-2 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-2 secretion" RELATED [GOC:TermGenie] is_a: GO:0032743 ! positive regulation of interleukin-2 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1900040 ! regulation of interleukin-2 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070970 ! interleukin-2 secretion relationship: positively_regulates GO:0070970 ! interleukin-2 secretion created_by: yaf creation_date: 2012-01-17T11:21:10Z [Term] id: GO:1900043 name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite namespace: biological_process def: "OBSOLETE. Any leptin-mediated signaling pathway that is involved in negative regulation of appetite." [GOC:BHF, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "adipocytokine signaling pathway of appetite suppression" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] synonym: "adipocytokine signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway involved in negative regulation of appetite" EXACT [] synonym: "leptin-mediated signaling pathway of appetite suppression" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of appetite suppression" RELATED [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of down regulation of appetite" EXACT [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of down-regulation of appetite" EXACT [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of downregulation of appetite" EXACT [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of inhibition of appetite" NARROW [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] synonym: "leptin-mediated signalling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] is_obsolete: true created_by: vk creation_date: 2012-01-19T11:10:22Z [Term] id: GO:1900044 name: regulation of protein K63-linked ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie] synonym: "regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] is_a: GO:1902914 ! regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070534 ! protein K63-linked ubiquitination relationship: regulates GO:0070534 ! protein K63-linked ubiquitination created_by: bf creation_date: 2012-01-19T11:44:37Z [Term] id: GO:1900045 name: negative regulation of protein K63-linked ubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie] synonym: "down regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] synonym: "down-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] synonym: "downregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] synonym: "inhibition of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "inhibition of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] synonym: "negative regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination is_a: GO:1902915 ! negative regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination relationship: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination created_by: bf creation_date: 2012-01-19T11:44:41Z [Term] id: GO:1900046 name: regulation of hemostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie] is_a: GO:0050789 ! regulation of biological process is_a: GO:0050878 ! regulation of body fluid levels intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007599 ! hemostasis relationship: regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:38Z [Term] id: GO:1900047 name: negative regulation of hemostasis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie] synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007599 ! hemostasis relationship: negatively_regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:42Z [Term] id: GO:1900048 name: positive regulation of hemostasis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie] synonym: "activation of hemostasis" NARROW [GOC:TermGenie] synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie] synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1900046 ! regulation of hemostasis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007599 ! hemostasis relationship: positively_regulates GO:0007599 ! hemostasis created_by: jl creation_date: 2012-01-19T03:23:45Z [Term] id: GO:1900049 name: regulation of histone exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] synonym: "regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "regulation of histone displacement" EXACT [GOC:TermGenie] synonym: "regulation of histone replacement" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043486 ! histone exchange relationship: regulates GO:0043486 ! histone exchange created_by: se creation_date: 2012-01-19T10:59:02Z [Term] id: GO:1900050 name: negative regulation of histone exchange namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] synonym: "down regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "down regulation of histone exchange" RELATED [GOC:TermGenie] synonym: "down regulation of histone replacement" EXACT [GOC:TermGenie] synonym: "down-regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "down-regulation of histone exchange" RELATED [GOC:TermGenie] synonym: "down-regulation of histone replacement" EXACT [GOC:TermGenie] synonym: "downregulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "downregulation of histone exchange" RELATED [GOC:TermGenie] synonym: "downregulation of histone replacement" EXACT [GOC:TermGenie] synonym: "inhibition of histone chaperone" RELATED [GOC:TermGenie] synonym: "inhibition of histone exchange" RELATED [GOC:TermGenie] synonym: "inhibition of histone replacement" EXACT [GOC:TermGenie] synonym: "negative regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "negative regulation of histone replacement" EXACT [GOC:TermGenie] is_a: GO:1900049 ! regulation of histone exchange is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043486 ! histone exchange relationship: negatively_regulates GO:0043486 ! histone exchange created_by: se creation_date: 2012-01-19T10:59:09Z [Term] id: GO:1900051 name: positive regulation of histone exchange namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] synonym: "activation of histone chaperone" RELATED [GOC:TermGenie] synonym: "activation of histone exchange" RELATED [GOC:TermGenie] synonym: "activation of histone replacement" EXACT [GOC:TermGenie] synonym: "positive regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "positive regulation of histone replacement" EXACT [GOC:TermGenie] synonym: "up regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "up regulation of histone exchange" RELATED [GOC:TermGenie] synonym: "up regulation of histone replacement" EXACT [GOC:TermGenie] synonym: "up-regulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "up-regulation of histone exchange" RELATED [GOC:TermGenie] synonym: "up-regulation of histone replacement" EXACT [GOC:TermGenie] synonym: "upregulation of histone chaperone" RELATED [GOC:TermGenie] synonym: "upregulation of histone exchange" RELATED [GOC:TermGenie] synonym: "upregulation of histone replacement" EXACT [GOC:TermGenie] is_a: GO:1900049 ! regulation of histone exchange is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043486 ! histone exchange relationship: positively_regulates GO:0043486 ! histone exchange created_by: se creation_date: 2012-01-19T10:59:12Z [Term] id: GO:1900052 name: regulation of retinoic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002138 ! retinoic acid biosynthetic process relationship: regulates GO:0002138 ! retinoic acid biosynthetic process created_by: yaf creation_date: 2012-01-20T09:55:45Z [Term] id: GO:1900053 name: negative regulation of retinoic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process relationship: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process created_by: yaf creation_date: 2012-01-20T09:55:49Z [Term] id: GO:1900054 name: positive regulation of retinoic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "activation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002138 ! retinoic acid biosynthetic process relationship: positively_regulates GO:0002138 ! retinoic acid biosynthetic process created_by: yaf creation_date: 2012-01-20T09:55:52Z [Term] id: GO:1900055 name: regulation of leaf senescence namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf senescence." [GOC:TermGenie] is_a: GO:2000024 ! regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010150 ! leaf senescence relationship: regulates GO:0010150 ! leaf senescence created_by: tb creation_date: 2012-01-24T11:51:24Z [Term] id: GO:1900056 name: negative regulation of leaf senescence namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence." [GOC:TermGenie] synonym: "down regulation of leaf senescence" RELATED [GOC:TermGenie] synonym: "down-regulation of leaf senescence" RELATED [GOC:TermGenie] synonym: "downregulation of leaf senescence" RELATED [GOC:TermGenie] synonym: "inhibition of leaf senescence" RELATED [GOC:TermGenie] is_a: GO:1900055 ! regulation of leaf senescence is_a: GO:1905622 ! negative regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010150 ! leaf senescence relationship: negatively_regulates GO:0010150 ! leaf senescence created_by: tb creation_date: 2012-01-24T11:51:32Z [Term] id: GO:1900057 name: positive regulation of leaf senescence namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leaf senescence." [GOC:TermGenie] synonym: "activation of leaf senescence" RELATED [GOC:TermGenie] synonym: "up regulation of leaf senescence" RELATED [GOC:TermGenie] synonym: "up-regulation of leaf senescence" RELATED [GOC:TermGenie] synonym: "upregulation of leaf senescence" RELATED [GOC:TermGenie] is_a: GO:1900055 ! regulation of leaf senescence is_a: GO:1905623 ! positive regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010150 ! leaf senescence relationship: positively_regulates GO:0010150 ! leaf senescence created_by: tb creation_date: 2012-01-24T11:51:36Z [Term] id: GO:1900058 name: regulation of sulfate assimilation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681] synonym: "regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "regulation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] is_a: GO:0042762 ! regulation of sulfur metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000103 ! sulfate assimilation relationship: regulates GO:0000103 ! sulfate assimilation created_by: dph creation_date: 2012-01-25T03:14:40Z [Term] id: GO:1900059 name: positive regulation of sulfate assimilation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681] synonym: "activation of sulfate assimilation" RELATED [GOC:TermGenie] synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "activation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "positive regulation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "up regulation of sulfate assimilation" RELATED [GOC:TermGenie] synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "up regulation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "up-regulation of sulfate assimilation" RELATED [GOC:TermGenie] synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "up-regulation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "upregulation of sulfate assimilation" RELATED [GOC:TermGenie] synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] synonym: "upregulation of sulphate assimilation" EXACT [GOC:TermGenie] synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900058 ! regulation of sulfate assimilation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000103 ! sulfate assimilation relationship: positively_regulates GO:0000103 ! sulfate assimilation created_by: dph creation_date: 2012-01-25T03:14:47Z [Term] id: GO:1900060 name: negative regulation of ceramide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:TermGenie, PMID:15302821] synonym: "down regulation of ceramide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of ceramide formation" EXACT [GOC:TermGenie] synonym: "down regulation of ceramide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ceramide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of ceramide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ceramide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ceramide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ceramide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of ceramide formation" EXACT [GOC:TermGenie] synonym: "downregulation of ceramide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ceramide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ceramide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ceramide biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of ceramide formation" EXACT [GOC:TermGenie] synonym: "inhibition of ceramide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ceramide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ceramide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ceramide synthesis" EXACT [GOC:TermGenie] is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process is_a: GO:2000303 ! regulation of ceramide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046513 ! ceramide biosynthetic process relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process created_by: dph creation_date: 2012-01-25T03:18:07Z [Term] id: GO:1900061 name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling namespace: biological_process def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036] comment: This term was made obsolete because it represents a GO-CAM model. synonym: "activation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signaling" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] is_obsolete: true created_by: dph creation_date: 2012-01-26T01:42:53Z [Term] id: GO:1900062 name: regulation of replicative cell aging namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replicative cell aging." [GOC:TermGenie, PMID:17914901] synonym: "regulation of replicative cell ageing" EXACT [GOC:TermGenie] is_a: GO:0090342 ! regulation of cell aging intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001302 ! replicative cell aging relationship: regulates GO:0001302 ! replicative cell aging created_by: dph creation_date: 2012-01-26T01:46:47Z [Term] id: GO:1900063 name: regulation of peroxisome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953] synonym: "regulation of peroxisome organisation" EXACT [GOC:TermGenie] synonym: "regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007031 ! peroxisome organization relationship: regulates GO:0007031 ! peroxisome organization created_by: dph creation_date: 2012-01-26T01:49:05Z [Term] id: GO:1900064 name: positive regulation of peroxisome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953] synonym: "activation of peroxisome organisation" NARROW [GOC:TermGenie] synonym: "activation of peroxisome organization" NARROW [GOC:TermGenie] synonym: "activation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "activation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of peroxisome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] synonym: "up regulation of peroxisome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of peroxisome organization" RELATED [GOC:TermGenie] synonym: "up regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of peroxisome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of peroxisome organization" RELATED [GOC:TermGenie] synonym: "up-regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] synonym: "upregulation of peroxisome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of peroxisome organization" RELATED [GOC:TermGenie] synonym: "upregulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1900063 ! regulation of peroxisome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007031 ! peroxisome organization relationship: positively_regulates GO:0007031 ! peroxisome organization created_by: dph creation_date: 2012-01-26T01:49:09Z [Term] id: GO:1900065 name: regulation of ethanol catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841] synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006068 ! ethanol catabolic process relationship: regulates GO:0006068 ! ethanol catabolic process created_by: dph creation_date: 2012-01-26T01:51:40Z [Term] id: GO:1900066 name: positive regulation of ethanol catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841] synonym: "activation of ethanol breakdown" NARROW [GOC:TermGenie] synonym: "activation of ethanol catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ethanol catabolism" NARROW [GOC:TermGenie] synonym: "activation of ethanol degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ethanol degradation" EXACT [GOC:TermGenie] synonym: "up regulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of ethanol catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ethanol degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of ethanol catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ethanol degradation" EXACT [GOC:TermGenie] synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900065 ! regulation of ethanol catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006068 ! ethanol catabolic process relationship: positively_regulates GO:0006068 ! ethanol catabolic process created_by: dph creation_date: 2012-01-26T01:51:44Z [Term] id: GO:1900067 name: regulation of cellular response to alkaline pH namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] synonym: "regulation of cellular response to alkalinity" BROAD [] synonym: "regulation of cellular response to basic pH" EXACT [GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071469 ! cellular response to alkaline pH relationship: regulates GO:0071469 ! cellular response to alkaline pH created_by: pr creation_date: 2012-01-26T02:34:59Z [Term] id: GO:1900068 name: negative regulation of cellular response to alkaline pH namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] synonym: "down regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to alkalinity" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to basic pH" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to alkalinity" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to basic pH" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to alkalinity" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to basic pH" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to alkaline pH" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to alkalinity" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to basic pH" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to alkalinity" BROAD [] synonym: "negative regulation of cellular response to basic pH" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900067 ! regulation of cellular response to alkaline pH intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071469 ! cellular response to alkaline pH relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH created_by: pr creation_date: 2012-01-26T02:35:03Z [Term] id: GO:1900069 name: regulation of cellular hyperosmotic salinity response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455] synonym: "regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] is_a: GO:0106049 ! regulation of cellular response to osmotic stress is_a: GO:1901000 ! regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071475 ! cellular hyperosmotic salinity response relationship: regulates GO:0071475 ! cellular hyperosmotic salinity response created_by: pr creation_date: 2012-01-26T02:45:39Z [Term] id: GO:1900070 name: negative regulation of cellular hyperosmotic salinity response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455] synonym: "down regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] synonym: "downregulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] synonym: "inhibition of cellular hyperosmotic salinity response" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to hyperosmotic salt stress" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900069 ! regulation of cellular hyperosmotic salinity response is_a: GO:1901001 ! negative regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response created_by: pr creation_date: 2012-01-26T02:45:43Z [Term] id: GO:1900071 name: regulation of sulfite transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099] synonym: "regulation of sulphite transport" EXACT [GOC:TermGenie] is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000316 ! sulfite transport relationship: regulates GO:0000316 ! sulfite transport created_by: dph creation_date: 2012-01-26T08:41:10Z [Term] id: GO:1900072 name: positive regulation of sulfite transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099] synonym: "activation of sulfite transport" NARROW [GOC:TermGenie] synonym: "activation of sulphite transport" NARROW [GOC:TermGenie] synonym: "positive regulation of sulphite transport" EXACT [GOC:TermGenie] synonym: "up regulation of sulfite transport" RELATED [GOC:TermGenie] synonym: "up regulation of sulphite transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sulfite transport" RELATED [GOC:TermGenie] synonym: "up-regulation of sulphite transport" EXACT [GOC:TermGenie] synonym: "upregulation of sulfite transport" RELATED [GOC:TermGenie] synonym: "upregulation of sulphite transport" EXACT [GOC:TermGenie] is_a: GO:1900071 ! regulation of sulfite transport is_a: GO:1903793 ! positive regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000316 ! sulfite transport relationship: positively_regulates GO:0000316 ! sulfite transport created_by: dph creation_date: 2012-01-26T08:41:16Z [Term] id: GO:1900073 name: regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007274 ! neuromuscular synaptic transmission relationship: regulates GO:0007274 ! neuromuscular synaptic transmission created_by: kmv creation_date: 2012-01-26T10:14:10Z [Term] id: GO:1900074 name: negative regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission relationship: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission created_by: kmv creation_date: 2012-01-26T10:14:18Z [Term] id: GO:1900075 name: positive regulation of neuromuscular synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007274 ! neuromuscular synaptic transmission relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmission created_by: kmv creation_date: 2012-01-26T10:14:22Z [Term] id: GO:1900076 name: regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032869 ! cellular response to insulin stimulus relationship: regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:22:22Z [Term] id: GO:1900077 name: negative regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032869 ! cellular response to insulin stimulus relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:23:15Z [Term] id: GO:1900078 name: positive regulation of cellular response to insulin stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900076 ! regulation of cellular response to insulin stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032869 ! cellular response to insulin stimulus relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus created_by: yaf creation_date: 2012-01-31T11:24:30Z [Term] id: GO:1900079 name: regulation of arginine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie] synonym: "regulation of arginine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of arginine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of arginine formation" EXACT [GOC:TermGenie] synonym: "regulation of arginine synthesis" EXACT [GOC:TermGenie] is_a: GO:0000821 ! regulation of arginine metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006526 ! arginine biosynthetic process relationship: regulates GO:0006526 ! arginine biosynthetic process created_by: pr creation_date: 2012-02-01T03:57:36Z [Term] id: GO:1900080 name: positive regulation of arginine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie] synonym: "activation of arginine anabolism" NARROW [GOC:TermGenie] synonym: "activation of arginine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of arginine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of arginine formation" NARROW [GOC:TermGenie] synonym: "activation of arginine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of arginine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of arginine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of arginine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of arginine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of arginine formation" EXACT [GOC:TermGenie] synonym: "up regulation of arginine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of arginine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of arginine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of arginine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of arginine formation" EXACT [GOC:TermGenie] synonym: "upregulation of arginine synthesis" EXACT [GOC:TermGenie] is_a: GO:1900079 ! regulation of arginine biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006526 ! arginine biosynthetic process relationship: positively_regulates GO:0006526 ! arginine biosynthetic process created_by: pr creation_date: 2012-02-01T03:57:41Z [Term] id: GO:1900081 name: regulation of arginine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie] synonym: "regulation of arginine breakdown" EXACT [GOC:TermGenie] synonym: "regulation of arginine catabolism" EXACT [GOC:TermGenie] synonym: "regulation of arginine degradation" EXACT [GOC:TermGenie] is_a: GO:0000821 ! regulation of arginine metabolic process is_a: GO:0033241 ! regulation of cellular amine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006527 ! arginine catabolic process relationship: regulates GO:0006527 ! arginine catabolic process created_by: pr creation_date: 2012-02-01T04:04:39Z [Term] id: GO:1900082 name: negative regulation of arginine catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie] synonym: "down regulation of arginine breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of arginine catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of arginine catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of arginine degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of arginine breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of arginine catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of arginine catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of arginine degradation" EXACT [GOC:TermGenie] synonym: "downregulation of arginine breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of arginine catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of arginine catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of arginine degradation" EXACT [GOC:TermGenie] synonym: "inhibition of arginine breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of arginine catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of arginine catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of arginine degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of arginine breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of arginine catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of arginine degradation" EXACT [GOC:TermGenie] is_a: GO:0033242 ! negative regulation of cellular amine catabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:1900081 ! regulation of arginine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006527 ! arginine catabolic process relationship: negatively_regulates GO:0006527 ! arginine catabolic process created_by: pr creation_date: 2012-02-01T04:04:45Z [Term] id: GO:1900083 name: obsolete regulation of Sertoli cell proliferation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation." [GOC:pr, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of Sertoli cell proliferation" EXACT [] is_obsolete: true created_by: pr creation_date: 2012-02-02T03:10:50Z [Term] id: GO:1900084 name: regulation of peptidyl-tyrosine autophosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] synonym: "regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] is_a: GO:0031952 ! regulation of protein autophosphorylation is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation relationship: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation created_by: bf creation_date: 2012-02-03T10:17:07Z [Term] id: GO:1900085 name: negative regulation of peptidyl-tyrosine autophosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] synonym: "down regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "down regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "down regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "down-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "downregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "inhibition of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine autophosphorylation" NARROW [GOC:TermGenie] synonym: "negative regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "negative regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] is_a: GO:0031953 ! negative regulation of protein autophosphorylation is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation relationship: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation created_by: bf creation_date: 2012-02-03T10:17:12Z [Term] id: GO:1900086 name: positive regulation of peptidyl-tyrosine autophosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] synonym: "activation of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie] synonym: "activation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "activation of tyrosine autophosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "up regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "up-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] synonym: "upregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] is_a: GO:0031954 ! positive regulation of protein autophosphorylation is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation relationship: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation created_by: bf creation_date: 2012-02-03T10:17:15Z [Term] id: GO:1900087 name: positive regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "activation of G1/S transition of mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "up regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902808 ! positive regulation of cell cycle G1/S phase transition is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle relationship: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle created_by: rph creation_date: 2012-02-08T12:24:39Z [Term] id: GO:1900088 name: regulation of inositol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006021 ! inositol biosynthetic process relationship: regulates GO:0006021 ! inositol biosynthetic process created_by: dhl creation_date: 2012-02-08T06:27:11Z [Term] id: GO:1900089 name: negative regulation of inositol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "down regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "down regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of inositol formation" EXACT [GOC:TermGenie] synonym: "downregulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of inositol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of inositol formation" EXACT [GOC:TermGenie] synonym: "inhibition of inositol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900088 ! regulation of inositol biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006021 ! inositol biosynthetic process relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process created_by: dhl creation_date: 2012-02-08T06:27:28Z [Term] id: GO:1900090 name: positive regulation of inositol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "activation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "activation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of inositol formation" EXACT [GOC:TermGenie] synonym: "activation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "activation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "up regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of inositol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of inositol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of inositol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of inositol formation" EXACT [GOC:TermGenie] synonym: "upregulation of inositol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900088 ! regulation of inositol biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006021 ! inositol biosynthetic process relationship: positively_regulates GO:0006021 ! inositol biosynthetic process created_by: dhl creation_date: 2012-02-08T06:27:31Z [Term] id: GO:1900091 name: regulation of raffinose biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "regulation of raffinose synthesis" EXACT [GOC:TermGenie] is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0080091 ! regulation of raffinose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033529 ! raffinose biosynthetic process relationship: regulates GO:0033529 ! raffinose biosynthetic process created_by: dhl creation_date: 2012-02-08T06:31:54Z [Term] id: GO:1900092 name: negative regulation of raffinose biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "down regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "down regulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "down-regulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "downregulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of raffinose biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of raffinose formation" EXACT [GOC:TermGenie] synonym: "inhibition of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "negative regulation of raffinose synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1900091 ! regulation of raffinose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033529 ! raffinose biosynthetic process relationship: negatively_regulates GO:0033529 ! raffinose biosynthetic process created_by: dhl creation_date: 2012-02-08T06:31:58Z [Term] id: GO:1900093 name: positive regulation of raffinose biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] synonym: "activation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "activation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of raffinose biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of raffinose formation" EXACT [GOC:TermGenie] synonym: "activation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "positive regulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "up regulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "up-regulation of raffinose synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of raffinose anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of raffinose biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of raffinose formation" EXACT [GOC:TermGenie] synonym: "upregulation of raffinose synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900091 ! regulation of raffinose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033529 ! raffinose biosynthetic process relationship: positively_regulates GO:0033529 ! raffinose biosynthetic process created_by: dhl creation_date: 2012-02-08T06:32:01Z [Term] id: GO:1900094 name: regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry." [GOC:BHF, GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: vk creation_date: 2012-02-14T10:58:20Z [Term] id: GO:1900095 name: regulation of dosage compensation by inactivation of X chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:mr, GOC:TermGenie, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] synonym: "regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "regulation of X chromosome inactivation" EXACT [GOC:TermGenie] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009048 ! dosage compensation by inactivation of X chromosome relationship: regulates GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: hjd creation_date: 2012-02-14T07:29:45Z [Term] id: GO:1900096 name: negative regulation of dosage compensation by inactivation of X chromosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie] synonym: "down regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "down regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "down regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "down regulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "down-regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "down-regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "down-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "down-regulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "downregulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "downregulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "downregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "downregulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "inhibition of Barr body formation" RELATED [GOC:TermGenie] synonym: "inhibition of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "inhibition of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie] synonym: "inhibition of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "negative regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "negative regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "negative regulation of X chromosome inactivation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome relationship: negatively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: hjd creation_date: 2012-02-14T07:29:49Z [Term] id: GO:1900097 name: positive regulation of dosage compensation by inactivation of X chromosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie] synonym: "activation of Barr body formation" RELATED [GOC:TermGenie] synonym: "activation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "activation of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie] synonym: "activation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "positive regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "positive regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "positive regulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "up regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "up regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "up regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "up regulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "up-regulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "up-regulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "up-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "up-regulation of X chromosome inactivation" EXACT [GOC:TermGenie] synonym: "upregulation of Barr body formation" RELATED [GOC:TermGenie] synonym: "upregulation of chromosome inactivation" BROAD [GOC:TermGenie] synonym: "upregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] synonym: "upregulation of X chromosome inactivation" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome relationship: positively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome created_by: hjd creation_date: 2012-02-14T07:29:52Z [Term] id: GO:1900098 name: regulation of plasma cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "regulation of plasma cell development" RELATED [GOC:TermGenie] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0045577 ! regulation of B cell differentiation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002317 ! plasma cell differentiation relationship: regulates GO:0002317 ! plasma cell differentiation created_by: bf creation_date: 2012-02-15T10:46:00Z [Term] id: GO:1900099 name: negative regulation of plasma cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "down regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "down regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "down-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "downregulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of plasma cell development" RELATED [GOC:TermGenie] synonym: "inhibition of plasma cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of plasma cell development" RELATED [GOC:TermGenie] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0045578 ! negative regulation of B cell differentiation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1900098 ! regulation of plasma cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002317 ! plasma cell differentiation relationship: negatively_regulates GO:0002317 ! plasma cell differentiation created_by: bf creation_date: 2012-02-15T10:46:05Z [Term] id: GO:1900100 name: positive regulation of plasma cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] synonym: "activation of plasma cell development" RELATED [GOC:TermGenie] synonym: "activation of plasma cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "up-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of plasma cell development" RELATED [GOC:TermGenie] synonym: "upregulation of plasma cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0045579 ! positive regulation of B cell differentiation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1900098 ! regulation of plasma cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002317 ! plasma cell differentiation relationship: positively_regulates GO:0002317 ! plasma cell differentiation created_by: bf creation_date: 2012-02-15T10:46:08Z [Term] id: GO:1900101 name: regulation of endoplasmic reticulum unfolded protein response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] synonym: "regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "regulation of erUPR" EXACT [GOC:TermGenie] synonym: "regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response relationship: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: ppm creation_date: 2012-02-15T11:15:27Z [Term] id: GO:1900102 name: negative regulation of endoplasmic reticulum unfolded protein response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of erUPR" EXACT [GOC:TermGenie] synonym: "down regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of erUPR" EXACT [GOC:TermGenie] synonym: "down-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of erUPR" EXACT [GOC:TermGenie] synonym: "downregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "inhibition of erUPR" EXACT [GOC:TermGenie] synonym: "inhibition of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "negative regulation of erUPR" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response relationship: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: ppm creation_date: 2012-02-15T11:15:31Z [Term] id: GO:1900103 name: positive regulation of endoplasmic reticulum unfolded protein response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] synonym: "activation of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "activation of erUPR" EXACT [GOC:TermGenie] synonym: "activation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "positive regulation of erUPR" EXACT [GOC:TermGenie] synonym: "positive regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of erUPR" EXACT [GOC:TermGenie] synonym: "up regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of erUPR" EXACT [GOC:TermGenie] synonym: "up-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of ER unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of erUPR" EXACT [GOC:TermGenie] synonym: "upregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response relationship: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response created_by: ppm creation_date: 2012-02-15T11:15:35Z [Term] id: GO:1900104 name: regulation of hyaluranon cable assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] synonym: "regulation of HA cable assembly" EXACT [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036118 ! hyaluranon cable assembly relationship: regulates GO:0036118 ! hyaluranon cable assembly created_by: yaf creation_date: 2012-02-16T01:00:41Z [Term] id: GO:1900105 name: negative regulation of hyaluranon cable assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] synonym: "downregulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] synonym: "inhibition of HA cable assembly" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluranon cable assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of HA cable assembly" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1900104 ! regulation of hyaluranon cable assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036118 ! hyaluranon cable assembly relationship: negatively_regulates GO:0036118 ! hyaluranon cable assembly created_by: yaf creation_date: 2012-02-16T01:00:50Z [Term] id: GO:1900106 name: positive regulation of hyaluranon cable assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] synonym: "activation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "activation of hyaluranon cable assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "up regulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] synonym: "upregulation of HA cable assembly" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1900104 ! regulation of hyaluranon cable assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036118 ! hyaluranon cable assembly relationship: positively_regulates GO:0036118 ! hyaluranon cable assembly created_by: yaf creation_date: 2012-02-16T01:00:54Z [Term] id: GO:1900107 name: regulation of nodal signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "regulation of nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032925 ! regulation of activin receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038092 ! nodal signaling pathway relationship: regulates GO:0038092 ! nodal signaling pathway created_by: bf creation_date: 2012-02-16T03:34:19Z [Term] id: GO:1900108 name: negative regulation of nodal signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "down regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "down regulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of nodal signaling" NARROW [GOC:TermGenie] synonym: "inhibition of nodal signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of nodal signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of nodal signalling pathway" EXACT [GOC:mah] is_a: GO:0032926 ! negative regulation of activin receptor signaling pathway is_a: GO:1900107 ! regulation of nodal signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038092 ! nodal signaling pathway relationship: negatively_regulates GO:0038092 ! nodal signaling pathway created_by: bf creation_date: 2012-02-16T03:34:23Z [Term] id: GO:1900109 name: regulation of histone H3-K9 dimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] synonym: "regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] is_a: GO:0051570 ! regulation of histone H3-K9 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036123 ! histone H3-K9 dimethylation relationship: regulates GO:0036123 ! histone H3-K9 dimethylation created_by: bf creation_date: 2012-02-21T09:06:18Z [Term] id: GO:1900110 name: negative regulation of histone H3-K9 dimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] synonym: "down regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3 K9 dimethylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone H3-K9 dimethylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie] synonym: "negative regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "negative regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036123 ! histone H3-K9 dimethylation relationship: negatively_regulates GO:0036123 ! histone H3-K9 dimethylation created_by: bf creation_date: 2012-02-21T09:06:22Z [Term] id: GO:1900111 name: positive regulation of histone H3-K9 dimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] synonym: "activation of histone H3 K9 dimethylation" NARROW [GOC:TermGenie] synonym: "activation of histone H3-K9 dimethylation" NARROW [GOC:TermGenie] synonym: "activation of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie] synonym: "positive regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "positive regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036123 ! histone H3-K9 dimethylation relationship: positively_regulates GO:0036123 ! histone H3-K9 dimethylation created_by: bf creation_date: 2012-02-21T09:06:26Z [Term] id: GO:1900112 name: regulation of histone H3-K9 trimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] is_a: GO:0051570 ! regulation of histone H3-K9 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036124 ! histone H3-K9 trimethylation relationship: regulates GO:0036124 ! histone H3-K9 trimethylation created_by: bf creation_date: 2012-02-21T09:09:49Z [Term] id: GO:1900113 name: negative regulation of histone H3-K9 trimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] synonym: "down regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3-K9 trimethylation" NARROW [GOC:TermGenie] is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036124 ! histone H3-K9 trimethylation relationship: negatively_regulates GO:0036124 ! histone H3-K9 trimethylation created_by: bf creation_date: 2012-02-21T09:09:54Z [Term] id: GO:1900114 name: positive regulation of histone H3-K9 trimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] synonym: "activation of histone H3-K9 trimethylation" NARROW [GOC:TermGenie] synonym: "up regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036124 ! histone H3-K9 trimethylation relationship: positively_regulates GO:0036124 ! histone H3-K9 trimethylation created_by: bf creation_date: 2012-02-21T09:09:58Z [Term] id: GO:1900115 name: extracellular regulation of signal transduction namespace: biological_process def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0009966 ! regulation of signal transduction intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region created_by: bf creation_date: 2012-02-22T10:21:48Z [Term] id: GO:1900116 name: extracellular negative regulation of signal transduction namespace: biological_process def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900115 ! extracellular regulation of signal transduction intersection_of: GO:0009968 ! negative regulation of signal transduction intersection_of: occurs_in GO:0005576 ! extracellular region created_by: bf creation_date: 2012-02-22T10:27:56Z [Term] id: GO:1900117 name: regulation of execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097194 ! execution phase of apoptosis relationship: regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:20Z [Term] id: GO:1900118 name: negative regulation of execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097194 ! execution phase of apoptosis relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:24Z [Term] id: GO:1900119 name: positive regulation of execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097194 ! execution phase of apoptosis relationship: positively_regulates GO:0097194 ! execution phase of apoptosis created_by: pr creation_date: 2012-02-22T11:26:27Z [Term] id: GO:1900120 name: regulation of receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005102 ! signaling receptor binding relationship: regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:40:53Z [Term] id: GO:1900121 name: negative regulation of receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005102 ! signaling receptor binding relationship: negatively_regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:40:57Z [Term] id: GO:1900122 name: positive regulation of receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] synonym: "activation of receptor binding" NARROW [GOC:TermGenie] synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005102 ! signaling receptor binding relationship: positively_regulates GO:0005102 ! signaling receptor binding created_by: bf creation_date: 2012-02-22T11:41:00Z [Term] id: GO:1900123 name: regulation of nodal receptor complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104] synonym: "regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] synonym: "regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:1900107 ! regulation of nodal signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038099 ! nodal receptor complex assembly relationship: regulates GO:0038099 ! nodal receptor complex assembly created_by: bf creation_date: 2012-02-22T04:21:49Z [Term] id: GO:1900124 name: negative regulation of nodal receptor complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104] synonym: "down regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of nodal receptor complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of ActRIIB.ALK4.EGF-CFC complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of nodal receptor complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of nodal receptor complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1900108 ! negative regulation of nodal signaling pathway is_a: GO:1900123 ! regulation of nodal receptor complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038099 ! nodal receptor complex assembly relationship: negatively_regulates GO:0038099 ! nodal receptor complex assembly created_by: bf creation_date: 2012-02-22T04:21:53Z [Term] id: GO:1900125 name: regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030213 ! hyaluronan biosynthetic process relationship: regulates GO:0030213 ! hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:21Z [Term] id: GO:1900126 name: negative regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process relationship: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:29Z [Term] id: GO:1900127 name: positive regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030213 ! hyaluronan biosynthetic process relationship: positively_regulates GO:0030213 ! hyaluronan biosynthetic process created_by: yaf creation_date: 2012-02-23T01:09:33Z [Term] id: GO:1900128 name: regulation of G-protein activated inward rectifier potassium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie] synonym: "regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity relationship: regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity created_by: bf creation_date: 2012-02-23T03:12:53Z [Term] id: GO:1900129 name: positive regulation of G-protein activated inward rectifier potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie] synonym: "activation of G protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of G protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of G-protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of G-protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of G-protein-activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of G-protein-enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] is_a: GO:1900128 ! regulation of G-protein activated inward rectifier potassium channel activity is_a: GO:1901980 ! positive regulation of inward rectifier potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity relationship: positively_regulates GO:0015467 ! G-protein activated inward rectifier potassium channel activity created_by: bf creation_date: 2012-02-23T03:12:58Z [Term] id: GO:1900130 name: regulation of lipid binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008289 ! lipid binding relationship: regulates GO:0008289 ! lipid binding created_by: pm creation_date: 2012-02-23T04:05:03Z [Term] id: GO:1900131 name: negative regulation of lipid binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie] synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1900130 ! regulation of lipid binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008289 ! lipid binding relationship: negatively_regulates GO:0008289 ! lipid binding created_by: pm creation_date: 2012-02-23T04:05:07Z [Term] id: GO:1900132 name: positive regulation of lipid binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] synonym: "activation of lipid binding" NARROW [GOC:TermGenie] synonym: "up regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "upregulation of lipid binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1900130 ! regulation of lipid binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008289 ! lipid binding relationship: positively_regulates GO:0008289 ! lipid binding created_by: pm creation_date: 2012-02-23T04:05:11Z [Term] id: GO:1900133 name: regulation of renin secretion into blood stream namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "regulation of renin release into blood stream" EXACT [GOC:TermGenie] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0098801 ! regulation of renal system process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002001 ! renin secretion into blood stream relationship: regulates GO:0002001 ! renin secretion into blood stream created_by: rph creation_date: 2012-02-27T10:32:01Z [Term] id: GO:1900134 name: negative regulation of renin secretion into blood stream namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "down regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "down regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "down-regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "down-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "downregulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "downregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "inhibition of renin release into blood stream" NARROW [GOC:TermGenie] synonym: "inhibition of renin secretion into blood stream" NARROW [GOC:TermGenie] synonym: "negative regulation of renin release into blood stream" EXACT [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:1900133 ! regulation of renin secretion into blood stream is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002001 ! renin secretion into blood stream relationship: negatively_regulates GO:0002001 ! renin secretion into blood stream created_by: rph creation_date: 2012-02-27T10:32:05Z [Term] id: GO:1900135 name: positive regulation of renin secretion into blood stream namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] synonym: "activation of renin release into blood stream" NARROW [GOC:TermGenie] synonym: "activation of renin secretion into blood stream" NARROW [GOC:TermGenie] synonym: "positive regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "up-regulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "up-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] synonym: "upregulation of renin release into blood stream" EXACT [GOC:TermGenie] synonym: "upregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:1900133 ! regulation of renin secretion into blood stream is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002001 ! renin secretion into blood stream relationship: positively_regulates GO:0002001 ! renin secretion into blood stream created_by: rph creation_date: 2012-02-27T10:32:08Z [Term] id: GO:1900136 name: regulation of chemokine activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine activity." [GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0060300 ! regulation of cytokine activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008009 ! chemokine activity relationship: regulates GO:0008009 ! chemokine activity created_by: bf creation_date: 2012-02-28T01:36:29Z [Term] id: GO:1900137 name: negative regulation of chemokine activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity." [GOC:TermGenie] synonym: "down regulation of chemokine activity" EXACT [GOC:TermGenie] synonym: "down-regulation of chemokine activity" EXACT [GOC:TermGenie] synonym: "downregulation of chemokine activity" EXACT [GOC:TermGenie] synonym: "inhibition of chemokine activity" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0060302 ! negative regulation of cytokine activity is_a: GO:1900136 ! regulation of chemokine activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008009 ! chemokine activity relationship: negatively_regulates GO:0008009 ! chemokine activity created_by: bf creation_date: 2012-02-28T01:36:33Z [Term] id: GO:1900138 name: negative regulation of phospholipase A2 activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity." [GOC:TermGenie] synonym: "down regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "down regulation of lecithinase A activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidase activity" RELATED [GOC:TermGenie] synonym: "down regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phospholipase A" RELATED [GOC:TermGenie] synonym: "down regulation of phospholipase A2 activity" EXACT [GOC:TermGenie] synonym: "down regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of lecithinase A activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipase A" RELATED [GOC:TermGenie] synonym: "down-regulation of phospholipase A2 activity" EXACT [GOC:TermGenie] synonym: "down-regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "downregulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "downregulation of lecithinase A activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidase activity" RELATED [GOC:TermGenie] synonym: "downregulation of phosphatidolipase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipase A" RELATED [GOC:TermGenie] synonym: "downregulation of phospholipase A2 activity" EXACT [GOC:TermGenie] synonym: "downregulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "inhibition of lecithinase A activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidase activity" RELATED [GOC:TermGenie] synonym: "inhibition of phosphatidolipase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylcholine 2-acylhydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phospholipase A" RELATED [GOC:TermGenie] synonym: "inhibition of phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "inhibition of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of lecithinase A activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phospholipase A" RELATED [GOC:TermGenie] synonym: "negative regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] is_a: GO:0010519 ! negative regulation of phospholipase activity is_a: GO:0032429 ! regulation of phospholipase A2 activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004623 ! phospholipase A2 activity relationship: negatively_regulates GO:0004623 ! phospholipase A2 activity created_by: rph creation_date: 2012-03-01T09:18:24Z [Term] id: GO:1900139 name: negative regulation of arachidonic acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion." [GOC:TermGenie] synonym: "down regulation of arachidonic acid secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of arachidonic acid secretion" EXACT [GOC:TermGenie] synonym: "downregulation of arachidonic acid secretion" EXACT [GOC:TermGenie] synonym: "inhibition of arachidonic acid secretion" NARROW [GOC:TermGenie] is_a: GO:0032304 ! negative regulation of icosanoid secretion is_a: GO:0090237 ! regulation of arachidonic acid secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050482 ! arachidonic acid secretion relationship: negatively_regulates GO:0050482 ! arachidonic acid secretion created_by: rph creation_date: 2012-03-01T09:21:19Z [Term] id: GO:1900140 name: regulation of seedling development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seedling development." [GOC:TermGenie] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090351 ! seedling development relationship: regulates GO:0090351 ! seedling development created_by: dhl creation_date: 2012-03-01T09:26:07Z [Term] id: GO:1900141 name: regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034350 ! regulation of glial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097252 ! oligodendrocyte apoptotic process relationship: regulates GO:0097252 ! oligodendrocyte apoptotic process created_by: yaf creation_date: 2012-03-06T10:22:45Z [Term] id: GO:1900142 name: negative regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034351 ! negative regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process relationship: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process created_by: yaf creation_date: 2012-03-06T10:22:50Z [Term] id: GO:1900143 name: positive regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034352 ! positive regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process relationship: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process created_by: yaf creation_date: 2012-03-06T10:22:54Z [Term] id: GO:1900144 name: positive regulation of BMP secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of BMP secretion." [GOC:sart, GOC:TermGenie] synonym: "activation of BMP protein secretion" NARROW [GOC:TermGenie] synonym: "activation of BMP secretion" NARROW [GOC:TermGenie] synonym: "activation of bone morphogenetic protein secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of BMP protein secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] synonym: "up regulation of BMP protein secretion" EXACT [GOC:TermGenie] synonym: "up regulation of BMP secretion" EXACT [GOC:TermGenie] synonym: "up regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP protein secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] synonym: "upregulation of BMP protein secretion" EXACT [GOC:TermGenie] synonym: "upregulation of BMP secretion" EXACT [GOC:TermGenie] synonym: "upregulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:2001284 ! regulation of BMP secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038055 ! BMP secretion relationship: positively_regulates GO:0038055 ! BMP secretion created_by: sart creation_date: 2012-03-06T10:31:47Z [Term] id: GO:1900145 name: regulation of nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] synonym: "regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:1900107 ! regulation of nodal signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry relationship: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry created_by: bf creation_date: 2012-03-06T11:00:32Z [Term] id: GO:1900146 name: negative regulation of nodal signaling pathway involved in determination of left/right asymmetry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] synonym: "down regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] synonym: "inhibition of nodal signaling pathway involved in determination of left/right asymmetry" NARROW [GOC:TermGenie] synonym: "negative regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1900108 ! negative regulation of nodal signaling pathway is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry relationship: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry created_by: bf creation_date: 2012-03-06T11:00:36Z [Term] id: GO:1900147 name: regulation of Schwann cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036135 ! Schwann cell migration relationship: regulates GO:0036135 ! Schwann cell migration created_by: bf creation_date: 2012-03-06T04:14:50Z [Term] id: GO:1900148 name: negative regulation of Schwann cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903976 ! negative regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036135 ! Schwann cell migration relationship: negatively_regulates GO:0036135 ! Schwann cell migration created_by: bf creation_date: 2012-03-06T04:14:55Z [Term] id: GO:1900149 name: positive regulation of Schwann cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903977 ! positive regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036135 ! Schwann cell migration relationship: positively_regulates GO:0036135 ! Schwann cell migration created_by: bf creation_date: 2012-03-06T04:14:58Z [Term] id: GO:1900150 name: regulation of defense response to fungus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006] synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie] synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie] synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050832 ! defense response to fungus relationship: regulates GO:0050832 ! defense response to fungus created_by: dhl creation_date: 2012-03-06T10:00:16Z [Term] id: GO:1900151 name: regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] synonym: "regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] is_a: GO:0061013 ! regulation of mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay relationship: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay created_by: bf creation_date: 2012-03-07T09:14:43Z [Term] id: GO:1900152 name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] synonym: "down regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "downregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "inhibition of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "negative regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay is_a: GO:1902373 ! negative regulation of mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay relationship: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay created_by: bf creation_date: 2012-03-07T09:14:49Z [Term] id: GO:1900153 name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] synonym: "activation of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie] synonym: "activation of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "activation of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie] synonym: "activation of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie] synonym: "activation of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie] synonym: "activation of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie] synonym: "activation of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "activation of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] synonym: "positive regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "upregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay relationship: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay created_by: bf creation_date: 2012-03-07T09:14:52Z [Term] id: GO:1900154 name: regulation of bone trabecula formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "regulation of skeletal trabeculation" EXACT [GOC:TermGenie] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060346 ! bone trabecula formation relationship: regulates GO:0060346 ! bone trabecula formation created_by: vk creation_date: 2012-03-07T01:47:03Z [Term] id: GO:1900155 name: negative regulation of bone trabecula formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "down regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "down regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "down regulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "down-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "down-regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "downregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "downregulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "inhibition of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of bone trabecula formation" NARROW [GOC:TermGenie] synonym: "inhibition of bone trabeculation" NARROW [GOC:TermGenie] synonym: "inhibition of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of skeletal trabecula formation" NARROW [GOC:TermGenie] synonym: "inhibition of skeletal trabeculation" NARROW [GOC:TermGenie] synonym: "negative regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "negative regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "negative regulation of skeletal trabeculation" EXACT [GOC:TermGenie] is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1900154 ! regulation of bone trabecula formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060346 ! bone trabecula formation relationship: negatively_regulates GO:0060346 ! bone trabecula formation created_by: vk creation_date: 2012-03-07T01:47:07Z [Term] id: GO:1900156 name: positive regulation of bone trabecula formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] synonym: "activation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "activation of bone trabecula formation" NARROW [GOC:TermGenie] synonym: "activation of bone trabeculation" NARROW [GOC:TermGenie] synonym: "activation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "activation of skeletal trabecula formation" NARROW [GOC:TermGenie] synonym: "activation of skeletal trabeculation" NARROW [GOC:TermGenie] synonym: "positive regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "positive regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "positive regulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "up regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "up regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "up regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "up regulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "up-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "up-regulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal trabeculation" EXACT [GOC:TermGenie] synonym: "upregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of bone trabecula formation" EXACT [GOC:TermGenie] synonym: "upregulation of bone trabeculation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of skeletal trabecula formation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal trabeculation" EXACT [GOC:TermGenie] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1900154 ! regulation of bone trabecula formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060346 ! bone trabecula formation relationship: positively_regulates GO:0060346 ! bone trabecula formation created_by: vk creation_date: 2012-03-07T01:47:10Z [Term] id: GO:1900157 name: regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035630 ! bone mineralization involved in bone maturation relationship: regulates GO:0035630 ! bone mineralization involved in bone maturation created_by: vk creation_date: 2012-03-07T08:55:07Z [Term] id: GO:1900158 name: negative regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "downregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "inhibition of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] is_a: GO:0030502 ! negative regulation of bone mineralization is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation is_a: GO:1903011 ! negative regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation relationship: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation created_by: vk creation_date: 2012-03-07T08:55:12Z [Term] id: GO:1900159 name: positive regulation of bone mineralization involved in bone maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] synonym: "activation of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] synonym: "up regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] synonym: "upregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] is_a: GO:0030501 ! positive regulation of bone mineralization is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation is_a: GO:1903012 ! positive regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation relationship: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation created_by: vk creation_date: 2012-03-07T08:55:16Z [Term] id: GO:1900160 name: plastid DNA packaging namespace: biological_process def: "Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] synonym: "plastidial DNA packaging" EXACT [GOC:emb] is_a: GO:0036385 ! nucleoid DNA packaging intersection_of: GO:0006323 ! DNA packaging intersection_of: occurs_in GO:0009536 ! plastid relationship: occurs_in GO:0009536 ! plastid created_by: bf creation_date: 2012-03-08T10:51:50Z [Term] id: GO:1900161 name: regulation of phospholipid scramblase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] is_a: GO:0061091 ! regulation of phospholipid translocation is_a: GO:0110112 ! regulation of lipid transporter activity is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017128 ! phospholipid scramblase activity relationship: regulates GO:0017128 ! phospholipid scramblase activity created_by: rph creation_date: 2012-03-08T10:57:19Z [Term] id: GO:1900162 name: negative regulation of phospholipid scramblase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] synonym: "down regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] synonym: "inhibition of phospholipid scramblase activity" NARROW [GOC:TermGenie] is_a: GO:0061093 ! negative regulation of phospholipid translocation is_a: GO:0110114 ! negative regulation of lipid transporter activity is_a: GO:1900161 ! regulation of phospholipid scramblase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017128 ! phospholipid scramblase activity relationship: negatively_regulates GO:0017128 ! phospholipid scramblase activity created_by: rph creation_date: 2012-03-08T10:57:23Z [Term] id: GO:1900163 name: positive regulation of phospholipid scramblase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] synonym: "activation of phospholipid scramblase activity" NARROW [GOC:TermGenie] synonym: "up regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] is_a: GO:0061092 ! positive regulation of phospholipid translocation is_a: GO:0110113 ! positive regulation of lipid transporter activity is_a: GO:1900161 ! regulation of phospholipid scramblase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017128 ! phospholipid scramblase activity relationship: positively_regulates GO:0017128 ! phospholipid scramblase activity created_by: rph creation_date: 2012-03-08T10:57:26Z [Term] id: GO:1900164 name: nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry intersection_of: GO:0038092 ! nodal signaling pathway intersection_of: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm created_by: bf creation_date: 2012-03-08T02:58:39Z [Term] id: GO:1900165 name: negative regulation of interleukin-6 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of IL-6 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-6 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-6 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-6 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IL-6 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-6 secretion" EXACT [GOC:TermGenie] synonym: "inhibition of IL-6 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-6 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of IL-6 secretion" EXACT [GOC:TermGenie] is_a: GO:0032715 ! negative regulation of interleukin-6 production is_a: GO:0050710 ! negative regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072604 ! interleukin-6 secretion relationship: negatively_regulates GO:0072604 ! interleukin-6 secretion created_by: yaf creation_date: 2012-03-08T03:27:05Z [Term] id: GO:1900166 name: regulation of glial cell-derived neurotrophic factor secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf] synonym: "regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion relationship: regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion created_by: yaf creation_date: 2012-03-08T03:44:39Z [Term] id: GO:1900167 name: negative regulation of glial cell-derived neurotrophic factor secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "down regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] synonym: "downregulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "downregulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] synonym: "inhibition of GDNF secretion" NARROW [GOC:TermGenie] synonym: "inhibition of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion relationship: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion created_by: yaf creation_date: 2012-03-08T03:44:43Z [Term] id: GO:1900168 name: positive regulation of glial cell-derived neurotrophic factor secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor secretion." [GOC:TermGenie, GOC:yaf] synonym: "activation of GDNF secretion" NARROW [GOC:TermGenie] synonym: "activation of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] synonym: "up regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "up regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] synonym: "upregulation of GDNF secretion" EXACT [GOC:TermGenie] synonym: "upregulation of glial cell line-derived neurotrophic factor secretion" EXACT [GOC:TermGenie] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion relationship: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor secretion created_by: yaf creation_date: 2012-03-08T03:44:47Z [Term] id: GO:1900169 name: regulation of glucocorticoid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] synonym: "regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043402 ! glucocorticoid mediated signaling pathway relationship: regulates GO:0043402 ! glucocorticoid mediated signaling pathway created_by: hjd creation_date: 2012-03-08T08:33:16Z [Term] id: GO:1900170 name: negative regulation of glucocorticoid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] synonym: "down regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "down-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "downregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "inhibition of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of glucocorticoid mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway relationship: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway created_by: hjd creation_date: 2012-03-08T08:33:20Z [Term] id: GO:1900171 name: positive regulation of glucocorticoid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] synonym: "activation of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of glucocorticoid mediated signalling" NARROW [GOC:TermGenie] synonym: "positive regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "up regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "up-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] synonym: "upregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway relationship: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway created_by: hjd creation_date: 2012-03-08T08:33:23Z [Term] id: GO:1900175 name: regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk] synonym: "regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: bf creation_date: 2012-03-09T10:39:10Z [Term] id: GO:1900176 name: negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk, PMID:15084459] synonym: "down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:1900146 ! negative regulation of nodal signaling pathway involved in determination of left/right asymmetry is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: negatively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: bf creation_date: 2012-03-09T10:39:14Z [Term] id: GO:1900177 name: regulation of aflatoxin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] synonym: "regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045122 ! aflatoxin biosynthetic process relationship: regulates GO:0045122 ! aflatoxin biosynthetic process created_by: di creation_date: 2012-03-09T11:23:35Z [Term] id: GO:1900178 name: negative regulation of aflatoxin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] synonym: "down regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "down regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "downregulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of aflatoxin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aflatoxin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of aflatoxin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of aflatoxin formation" NARROW [GOC:TermGenie] synonym: "inhibition of aflatoxin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process relationship: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process created_by: di creation_date: 2012-03-09T11:23:42Z [Term] id: GO:1900179 name: positive regulation of aflatoxin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] synonym: "activation of aflatoxin anabolism" NARROW [GOC:TermGenie] synonym: "activation of aflatoxin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of aflatoxin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of aflatoxin formation" NARROW [GOC:TermGenie] synonym: "activation of aflatoxin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "up regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of aflatoxin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of aflatoxin formation" EXACT [GOC:TermGenie] synonym: "upregulation of aflatoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045122 ! aflatoxin biosynthetic process relationship: positively_regulates GO:0045122 ! aflatoxin biosynthetic process created_by: di creation_date: 2012-03-09T11:23:46Z [Term] id: GO:1900180 name: regulation of protein localization to nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034504 ! protein localization to nucleus relationship: regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:44Z [Term] id: GO:1900181 name: negative regulation of protein localization to nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034504 ! protein localization to nucleus relationship: negatively_regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:48Z [Term] id: GO:1900182 name: positive regulation of protein localization to nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034504 ! protein localization to nucleus relationship: positively_regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:52Z [Term] id: GO:1900183 name: regulation of xanthone-containing compound biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001307 ! xanthone-containing compound biosynthetic process relationship: regulates GO:2001307 ! xanthone-containing compound biosynthetic process created_by: di creation_date: 2012-03-16T03:30:14Z [Term] id: GO:1900184 name: negative regulation of xanthone-containing compound biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "down regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "down-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "downregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "inhibition of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "negative regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of xanthones anabolism" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process relationship: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process created_by: di creation_date: 2012-03-16T03:30:24Z [Term] id: GO:1900185 name: positive regulation of xanthone-containing compound biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "activation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "activation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "positive regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "up regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "up-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of xanthone biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] synonym: "upregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process relationship: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process created_by: di creation_date: 2012-03-16T03:30:32Z [Term] id: GO:1900186 name: negative regulation of clathrin-dependent endocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:TermGenie] synonym: "down regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of clathrin-mediated endocytosis" NARROW [GOC:TermGenie] synonym: "negative regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "negative regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] synonym: "negative regulation of clathrin-mediated endocytosis" EXACT [] is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072583 ! clathrin-dependent endocytosis relationship: negatively_regulates GO:0072583 ! clathrin-dependent endocytosis created_by: hjd creation_date: 2012-03-16T05:25:02Z [Term] id: GO:1900187 name: regulation of cell adhesion involved in single-species biofilm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] is_a: GO:0010810 ! regulation of cell-substrate adhesion is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation relationship: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation created_by: di creation_date: 2012-03-19T12:38:45Z [Term] id: GO:1900188 name: negative regulation of cell adhesion involved in single-species biofilm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "down regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "down regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "downregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "downregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "inhibition of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "inhibition of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie] synonym: "negative regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] is_a: GO:0010812 ! negative regulation of cell-substrate adhesion is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation is_a: GO:1900191 ! negative regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation relationship: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation created_by: di creation_date: 2012-03-19T12:38:54Z [Term] id: GO:1900189 name: positive regulation of cell adhesion involved in single-species biofilm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "activation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "activation of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie] synonym: "positive regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "up regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "up regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "upregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] synonym: "upregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] is_a: GO:0010811 ! positive regulation of cell-substrate adhesion is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation is_a: GO:1900192 ! positive regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation relationship: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation created_by: di creation_date: 2012-03-19T12:39:03Z [Term] id: GO:1900190 name: regulation of single-species biofilm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044010 ! single-species biofilm formation relationship: regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:04Z [Term] id: GO:1900191 name: negative regulation of single-species biofilm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "down regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "downregulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "inhibition of single-species biofilm formation" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044010 ! single-species biofilm formation relationship: negatively_regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:13Z [Term] id: GO:1900192 name: positive regulation of single-species biofilm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] synonym: "activation of single-species biofilm formation" NARROW [GOC:TermGenie] synonym: "up regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] synonym: "upregulation of single-species biofilm formation" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044010 ! single-species biofilm formation relationship: positively_regulates GO:0044010 ! single-species biofilm formation created_by: di creation_date: 2012-03-19T12:42:21Z [Term] id: GO:1900193 name: regulation of oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001556 ! oocyte maturation relationship: regulates GO:0001556 ! oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:18Z [Term] id: GO:1900194 name: negative regulation of oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:0060283 ! negative regulation of oocyte development is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001556 ! oocyte maturation relationship: negatively_regulates GO:0001556 ! oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:27Z [Term] id: GO:1900195 name: positive regulation of oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:0060282 ! positive regulation of oocyte development is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001556 ! oocyte maturation relationship: positively_regulates GO:0001556 ! oocyte maturation created_by: kmv creation_date: 2012-03-19T09:41:35Z [Term] id: GO:1900196 name: regulation of penicillin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "regulation of penicillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0033244 ! regulation of penicillin metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042318 ! penicillin biosynthetic process relationship: regulates GO:0042318 ! penicillin biosynthetic process created_by: di creation_date: 2012-03-20T03:56:33Z [Term] id: GO:1900197 name: negative regulation of penicillin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "down regulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "downregulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of penicillin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of penicillin formation" EXACT [GOC:TermGenie] synonym: "inhibition of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of penicillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0033245 ! negative regulation of penicillin metabolic process is_a: GO:1900196 ! regulation of penicillin biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042318 ! penicillin biosynthetic process relationship: negatively_regulates GO:0042318 ! penicillin biosynthetic process created_by: di creation_date: 2012-03-20T03:56:43Z [Term] id: GO:1900198 name: positive regulation of penicillin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "activation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of penicillin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of penicillin formation" EXACT [GOC:TermGenie] synonym: "activation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "up regulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of penicillin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of penicillin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of penicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of penicillin formation" EXACT [GOC:TermGenie] synonym: "upregulation of penicillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0033246 ! positive regulation of penicillin metabolic process is_a: GO:1900196 ! regulation of penicillin biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042318 ! penicillin biosynthetic process relationship: positively_regulates GO:0042318 ! penicillin biosynthetic process created_by: di creation_date: 2012-03-20T03:56:52Z [Term] id: GO:1900199 name: positive regulation of protein export from nucleus during meiotic anaphase II namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II." [GOC:al, GOC:TermGenie, PMID:20970342] synonym: "positive regulation of protein export from nucleus involved in meiotic anaphase II" BROAD [GOC:pr] is_a: GO:0046827 ! positive regulation of protein export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: happens_during GO:0007138 ! meiotic anaphase II intersection_of: positively_regulates GO:0006611 ! protein export from nucleus relationship: happens_during GO:0007138 ! meiotic anaphase II created_by: pr creation_date: 2012-03-20T06:35:19Z [Term] id: GO:1900200 name: mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:0097152 ! mesenchymal cell apoptotic process is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: part_of GO:0001656 ! metanephros development relationship: part_of GO:0001656 ! metanephros development created_by: yaf creation_date: 2012-03-21T11:58:05Z [Term] id: GO:1900201 name: obsolete regulation of spread of virus in host, cell to cell namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "regulation of spread of virus in host, cell to cell" EXACT [] synonym: "regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: pm creation_date: 2012-03-21T01:15:41Z [Term] id: GO:1900202 name: obsolete negative regulation of spread of virus in host, cell to cell namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "down regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "down regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "down regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "down-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "down-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "down-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "downregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "downregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "downregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "downregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "inhibition of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "inhibition of spread of virus in host, cell to cell" NARROW [GOC:TermGenie] synonym: "inhibition of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "inhibition of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "negative regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "negative regulation of spread of virus in host, cell to cell" EXACT [] synonym: "negative regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "negative regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: pm creation_date: 2012-03-21T01:15:51Z [Term] id: GO:1900203 name: obsolete positive regulation of spread of virus in host, cell to cell namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "activation of spread of virus in host, cell to cell" NARROW [GOC:TermGenie] synonym: "activation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "activation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "positive regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "positive regulation of spread of virus in host, cell to cell" EXACT [] synonym: "positive regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "positive regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "up regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "up regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "up regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "up regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "up-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "up-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "up-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] synonym: "upregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] synonym: "upregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] synonym: "upregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] synonym: "upregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: pm creation_date: 2012-03-21T01:16:00Z [Term] id: GO:1900204 name: apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0072205 ! metanephric collecting duct development relationship: part_of GO:0072205 ! metanephric collecting duct development created_by: yaf creation_date: 2012-03-21T01:21:32Z [Term] id: GO:1900205 name: apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0072234 ! metanephric nephron tubule development relationship: part_of GO:0072234 ! metanephric nephron tubule development created_by: yaf creation_date: 2012-03-21T01:21:45Z [Term] id: GO:1900206 name: regulation of pronephric nephron tubule development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie] is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039020 ! pronephric nephron tubule development relationship: regulates GO:0039020 ! pronephric nephron tubule development created_by: bf creation_date: 2012-03-22T09:23:13Z [Term] id: GO:1900207 name: negative regulation of pronephric nephron tubule development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706] synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:1900206 ! regulation of pronephric nephron tubule development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039020 ! pronephric nephron tubule development relationship: negatively_regulates GO:0039020 ! pronephric nephron tubule development created_by: bf creation_date: 2012-03-22T09:23:23Z [Term] id: GO:1900208 name: regulation of cardiolipin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] synonym: "regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032048 ! cardiolipin metabolic process relationship: regulates GO:0032048 ! cardiolipin metabolic process created_by: jl creation_date: 2012-03-22T10:43:33Z [Term] id: GO:1900209 name: negative regulation of cardiolipin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] synonym: "down regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of cardiolipin metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] is_a: GO:1900208 ! regulation of cardiolipin metabolic process is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032048 ! cardiolipin metabolic process relationship: negatively_regulates GO:0032048 ! cardiolipin metabolic process created_by: jl creation_date: 2012-03-22T10:43:43Z [Term] id: GO:1900210 name: positive regulation of cardiolipin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] synonym: "activation of cardiolipin metabolic process" NARROW [GOC:TermGenie] synonym: "activation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "activation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "activation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cardiolipin metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] is_a: GO:1900208 ! regulation of cardiolipin metabolic process is_a: GO:1903727 ! positive regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032048 ! cardiolipin metabolic process relationship: positively_regulates GO:0032048 ! cardiolipin metabolic process created_by: jl creation_date: 2012-03-22T10:43:51Z [Term] id: GO:1900211 name: regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1904748 ! regulation of apoptotic process involved in development is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development relationship: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development created_by: yaf creation_date: 2012-03-22T10:52:50Z [Term] id: GO:1900212 name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development relationship: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development created_by: yaf creation_date: 2012-03-22T10:53:00Z [Term] id: GO:1900213 name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development relationship: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development created_by: yaf creation_date: 2012-03-22T10:53:09Z [Term] id: GO:1900214 name: regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development relationship: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development created_by: yaf creation_date: 2012-03-22T10:53:21Z [Term] id: GO:1900215 name: negative regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development relationship: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development created_by: yaf creation_date: 2012-03-22T10:53:31Z [Term] id: GO:1900216 name: positive regulation of apoptotic process involved in metanephric collecting duct development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development relationship: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development created_by: yaf creation_date: 2012-03-22T10:53:39Z [Term] id: GO:1900217 name: regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development relationship: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development created_by: yaf creation_date: 2012-03-22T10:53:51Z [Term] id: GO:1900218 name: negative regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development relationship: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development created_by: yaf creation_date: 2012-03-22T10:54:01Z [Term] id: GO:1900219 name: positive regulation of apoptotic process involved in metanephric nephron tubule development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development relationship: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development created_by: yaf creation_date: 2012-03-22T10:54:09Z [Term] id: GO:1900220 name: semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis namespace: biological_process def: "Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:0061430 ! bone trabecula morphogenesis relationship: part_of GO:0061430 ! bone trabecula morphogenesis created_by: vk creation_date: 2012-03-22T01:13:56Z [Term] id: GO:1900221 name: regulation of amyloid-beta clearance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] synonym: "regulation of beta-amyloid clearance" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097242 ! amyloid-beta clearance relationship: regulates GO:0097242 ! amyloid-beta clearance created_by: vk creation_date: 2012-03-22T01:29:32Z [Term] id: GO:1900222 name: negative regulation of amyloid-beta clearance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] synonym: "downregulation of beta-amyloid clearance" EXACT [GOC:TermGenie] synonym: "inhibition of beta-amyloid clearance" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-amyloid clearance" EXACT [] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1900221 ! regulation of amyloid-beta clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097242 ! amyloid-beta clearance relationship: negatively_regulates GO:0097242 ! amyloid-beta clearance created_by: vk creation_date: 2012-03-22T01:29:41Z [Term] id: GO:1900223 name: positive regulation of amyloid-beta clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] synonym: "activation of beta-amyloid clearance" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-amyloid clearance" EXACT [] synonym: "up regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] synonym: "upregulation of beta-amyloid clearance" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1900221 ! regulation of amyloid-beta clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097242 ! amyloid-beta clearance relationship: positively_regulates GO:0097242 ! amyloid-beta clearance created_by: vk creation_date: 2012-03-22T01:29:50Z [Term] id: GO:1900224 name: positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GOC:BHF, GOC:TermGenie] synonym: "activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] synonym: "up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] synonym: "upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] is_a: GO:0032927 ! positive regulation of activin receptor signaling pathway is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: positively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: vk creation_date: 2012-03-22T02:30:13Z [Term] id: GO:1900225 name: regulation of NLRP3 inflammasome complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] synonym: "regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044546 ! NLRP3 inflammasome complex assembly relationship: regulates GO:0044546 ! NLRP3 inflammasome complex assembly created_by: jl creation_date: 2012-03-22T04:18:14Z [Term] id: GO:1900226 name: negative regulation of NLRP3 inflammasome complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] synonym: "down regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "down regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "down-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "downregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "inhibition of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly relationship: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly created_by: jl creation_date: 2012-03-22T04:18:24Z [Term] id: GO:1900227 name: positive regulation of NLRP3 inflammasome complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] synonym: "activation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "activation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "activation of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "up regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "up regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "up-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] synonym: "upregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly relationship: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly created_by: jl creation_date: 2012-03-22T04:18:32Z [Term] id: GO:1900228 name: regulation of single-species biofilm formation in or on host organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044407 ! single-species biofilm formation in or on host organism relationship: regulates GO:0044407 ! single-species biofilm formation in or on host organism created_by: di creation_date: 2012-03-23T04:36:54Z [Term] id: GO:1900229 name: negative regulation of single-species biofilm formation in or on host organism namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] synonym: "down regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] synonym: "down-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] synonym: "downregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] synonym: "inhibition of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie] is_a: GO:1900191 ! negative regulation of single-species biofilm formation is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism relationship: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism created_by: di creation_date: 2012-03-23T04:37:05Z [Term] id: GO:1900230 name: positive regulation of single-species biofilm formation in or on host organism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] synonym: "activation of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie] synonym: "up regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] synonym: "up-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] synonym: "upregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] is_a: GO:1900192 ! positive regulation of single-species biofilm formation is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism relationship: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism created_by: di creation_date: 2012-03-23T04:37:14Z [Term] id: GO:1900231 name: regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:35Z [Term] id: GO:1900232 name: negative regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] synonym: "down regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "down-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "downregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "inhibition of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] is_a: GO:1900191 ! negative regulation of single-species biofilm formation is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:45Z [Term] id: GO:1900233 name: positive regulation of single-species biofilm formation on inanimate substrate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] synonym: "activation of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] synonym: "up regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "up-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] synonym: "upregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] is_a: GO:1900192 ! positive regulation of single-species biofilm formation is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate relationship: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate created_by: di creation_date: 2012-03-23T04:40:53Z [Term] id: GO:1900234 name: regulation of Kit signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] synonym: "regulation of Kit signalling pathway" EXACT [GOC:mah] synonym: "regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038109 ! Kit signaling pathway relationship: regulates GO:0038109 ! Kit signaling pathway created_by: bf creation_date: 2012-03-23T02:54:13Z [Term] id: GO:1900235 name: negative regulation of Kit signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of Kit signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of Kit signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1900234 ! regulation of Kit signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038109 ! Kit signaling pathway relationship: negatively_regulates GO:0038109 ! Kit signaling pathway created_by: bf creation_date: 2012-03-23T02:54:23Z [Term] id: GO:1900236 name: positive regulation of Kit signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] synonym: "activation of Kit signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of Kit signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Kit signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1900234 ! regulation of Kit signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038109 ! Kit signaling pathway relationship: positively_regulates GO:0038109 ! Kit signaling pathway created_by: bf creation_date: 2012-03-23T02:54:32Z [Term] id: GO:1900237 name: positive regulation of induction of conjugation with cellular fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion." [GOC:TermGenie] synonym: "up regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] synonym: "upregulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion created_by: al creation_date: 2012-03-26T10:14:16Z [Term] id: GO:1900238 name: regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway." [GOC:mtg_kidney_jan10, GOC:TermGenie, goc:yaf, PMID:19450854] synonym: "regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] synonym: "regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration intersection_of: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway intersection_of: regulates GO:0035789 ! metanephric mesenchymal cell migration created_by: yaf creation_date: 2012-03-27T03:33:56Z [Term] id: GO:1900239 name: regulation of phenotypic switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] synonym: "regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036166 ! phenotypic switching relationship: regulates GO:0036166 ! phenotypic switching created_by: di creation_date: 2012-03-28T01:49:16Z [Term] id: GO:1900240 name: negative regulation of phenotypic switching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] synonym: "down regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down regulation of phenotypic switching" EXACT [GOC:TermGenie] synonym: "down-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down-regulation of phenotypic switching" EXACT [GOC:TermGenie] synonym: "downregulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "downregulation of phenotypic switching" EXACT [GOC:TermGenie] synonym: "inhibition of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "inhibition of phenotypic switching" NARROW [GOC:TermGenie] synonym: "negative regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036166 ! phenotypic switching relationship: negatively_regulates GO:0036166 ! phenotypic switching created_by: di creation_date: 2012-03-28T01:49:26Z [Term] id: GO:1900241 name: positive regulation of phenotypic switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] synonym: "activation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "activation of phenotypic switching" NARROW [GOC:TermGenie] synonym: "positive regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up regulation of phenotypic switching" EXACT [GOC:TermGenie] synonym: "up-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up-regulation of phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "upregulation of phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036166 ! phenotypic switching relationship: positively_regulates GO:0036166 ! phenotypic switching created_by: di creation_date: 2012-03-28T01:49:34Z [Term] id: GO:1900242 name: regulation of synaptic vesicle endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] subset: goslim_synapse synonym: "regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:1903421 ! regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048488 ! synaptic vesicle endocytosis relationship: regulates GO:0048488 ! synaptic vesicle endocytosis created_by: rl creation_date: 2012-03-28T01:40:26Z [Term] id: GO:1900243 name: negative regulation of synaptic vesicle endocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "downregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "inhibition of synaptic vesicle endocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis is_a: GO:1903422 ! negative regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis relationship: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis created_by: rl creation_date: 2012-03-28T01:40:36Z [Term] id: GO:1900244 name: positive regulation of synaptic vesicle endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] synonym: "activation of synaptic vesicle endocytosis" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "up regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] synonym: "upregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis is_a: GO:1903423 ! positive regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048488 ! synaptic vesicle endocytosis relationship: positively_regulates GO:0048488 ! synaptic vesicle endocytosis created_by: rl creation_date: 2012-03-28T01:40:44Z [Term] id: GO:1900245 name: positive regulation of MDA-5 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway." [GOC:TermGenie] synonym: "activation of IFIH1 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of MDA-5 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of MDA5 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of melanoma differentiation-associated gene 5 signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of MDA-5 signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0039533 ! regulation of MDA-5 signaling pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0039530 ! MDA-5 signaling pathway relationship: positively_regulates GO:0039530 ! MDA-5 signaling pathway created_by: ss creation_date: 2012-04-02T10:55:38Z [Term] id: GO:1900246 name: positive regulation of RIG-I signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway." [GOC:TermGenie] synonym: "activation of DDX58 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of retinoic acid inducible gene I signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of RIG-I signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of RIG-I signalling pathway" EXACT [GOC:mah] synonym: "up regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0039535 ! regulation of RIG-I signaling pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0039529 ! RIG-I signaling pathway relationship: positively_regulates GO:0039529 ! RIG-I signaling pathway created_by: ss creation_date: 2012-04-02T11:00:28Z [Term] id: GO:1900247 name: regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002182 ! cytoplasmic translational elongation relationship: regulates GO:0002182 ! cytoplasmic translational elongation created_by: vw creation_date: 2012-04-03T05:07:02Z [Term] id: GO:1900248 name: negative regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation is_a: GO:2000766 ! negative regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002182 ! cytoplasmic translational elongation relationship: negatively_regulates GO:0002182 ! cytoplasmic translational elongation created_by: vw creation_date: 2012-04-03T05:07:14Z [Term] id: GO:1900249 name: positive regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation is_a: GO:2000767 ! positive regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002182 ! cytoplasmic translational elongation relationship: positively_regulates GO:0002182 ! cytoplasmic translational elongation created_by: vw creation_date: 2012-04-03T05:07:24Z [Term] id: GO:1900256 name: regulation of beta1-adrenergic receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] synonym: "regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004940 ! beta1-adrenergic receptor activity relationship: regulates GO:0004940 ! beta1-adrenergic receptor activity created_by: tb creation_date: 2012-04-03T10:59:21Z [Term] id: GO:1900257 name: negative regulation of beta1-adrenergic receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] synonym: "down regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "down regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "down-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "downregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] synonym: "inhibition of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "inhibition of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004940 ! beta1-adrenergic receptor activity relationship: negatively_regulates GO:0004940 ! beta1-adrenergic receptor activity created_by: tb creation_date: 2012-04-03T10:59:40Z [Term] id: GO:1900258 name: positive regulation of beta1-adrenergic receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] synonym: "activation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "activation of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "up regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "up regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "up-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] synonym: "upregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004940 ! beta1-adrenergic receptor activity relationship: positively_regulates GO:0004940 ! beta1-adrenergic receptor activity created_by: tb creation_date: 2012-04-03T10:59:49Z [Term] id: GO:1900259 name: regulation of RNA-directed 5'-3' RNA polymerase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] synonym: "regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of RDRP" RELATED [GOC:TermGenie] synonym: "regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA-directed RNA polymerase activity" BROAD [] synonym: "regulation of transcriptase" BROAD [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity relationship: regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity created_by: tb creation_date: 2012-04-03T11:01:53Z [Term] id: GO:1900260 name: negative regulation of RNA-directed 5'-3' RNA polymerase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] synonym: "down regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "down regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "down regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "down regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "down regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "down regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RDRP" RELATED [GOC:TermGenie] synonym: "down regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "down regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of transcriptase" BROAD [GOC:TermGenie] synonym: "down-regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "down-regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "down-regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "down-regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "down-regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "down-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RDRP" RELATED [GOC:TermGenie] synonym: "down-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of transcriptase" BROAD [GOC:TermGenie] synonym: "downregulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "downregulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "downregulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "downregulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "downregulation of polymerase L" RELATED [GOC:TermGenie] synonym: "downregulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RDRP" RELATED [GOC:TermGenie] synonym: "downregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "downregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of transcriptase" BROAD [GOC:TermGenie] synonym: "inhibition of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "inhibition of PB1 proteins" RELATED [GOC:TermGenie] synonym: "inhibition of PB2 proteins" RELATED [GOC:TermGenie] synonym: "inhibition of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "inhibition of polymerase L" RELATED [GOC:TermGenie] synonym: "inhibition of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of RDRP" RELATED [GOC:TermGenie] synonym: "inhibition of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "inhibition of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of transcriptase" BROAD [GOC:TermGenie] synonym: "negative regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "negative regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "negative regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "negative regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "negative regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "negative regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RDRP" RELATED [GOC:TermGenie] synonym: "negative regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA-directed RNA polymerase activity" BROAD [] synonym: "negative regulation of transcriptase" BROAD [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1900259 ! regulation of RNA-directed 5'-3' RNA polymerase activity is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity relationship: negatively_regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity created_by: tb creation_date: 2012-04-03T11:02:03Z [Term] id: GO:1900261 name: positive regulation of RNA-directed 5'-3' RNA polymerase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] synonym: "activation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "activation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "activation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "activation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "activation of polymerase L" RELATED [GOC:TermGenie] synonym: "activation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "activation of RDRP" RELATED [GOC:TermGenie] synonym: "activation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "activation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "activation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "activation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "activation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "activation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "activation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "activation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "activation of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of transcriptase" BROAD [GOC:TermGenie] synonym: "positive regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "positive regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "positive regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "positive regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "positive regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "positive regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RDRP" RELATED [GOC:TermGenie] synonym: "positive regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA-directed RNA polymerase activity" BROAD [] synonym: "positive regulation of transcriptase" BROAD [GOC:TermGenie] synonym: "up regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "up regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "up regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "up regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "up regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "up regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RDRP" RELATED [GOC:TermGenie] synonym: "up regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "up regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of transcriptase" BROAD [GOC:TermGenie] synonym: "up-regulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "up-regulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "up-regulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "up-regulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "up-regulation of polymerase L" RELATED [GOC:TermGenie] synonym: "up-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RDRP" RELATED [GOC:TermGenie] synonym: "up-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of transcriptase" BROAD [GOC:TermGenie] synonym: "upregulation of 3D polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] synonym: "upregulation of PB1 proteins" RELATED [GOC:TermGenie] synonym: "upregulation of PB2 proteins" RELATED [GOC:TermGenie] synonym: "upregulation of phage f2 replicase" NARROW [GOC:TermGenie] synonym: "upregulation of polymerase L" RELATED [GOC:TermGenie] synonym: "upregulation of Q-beta replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RDRP" RELATED [GOC:TermGenie] synonym: "upregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] synonym: "upregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthetase activity" RELATED [GOC:TermGenie] synonym: "upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of transcriptase" BROAD [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1900259 ! regulation of RNA-directed 5'-3' RNA polymerase activity is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity relationship: positively_regulates GO:0003968 ! RNA-directed 5'-3' RNA polymerase activity created_by: tb creation_date: 2012-04-03T11:02:11Z [Term] id: GO:1900262 name: regulation of DNA-directed DNA polymerase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] synonym: "regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of duplicase" BROAD [GOC:TermGenie] synonym: "regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of sequenase" RELATED [GOC:TermGenie] synonym: "regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity is_a: GO:0090329 ! regulation of DNA-dependent DNA replication is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003887 ! DNA-directed DNA polymerase activity relationship: regulates GO:0003887 ! DNA-directed DNA polymerase activity created_by: tb creation_date: 2012-04-03T11:07:08Z [Term] id: GO:1900263 name: negative regulation of DNA-directed DNA polymerase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] synonym: "down regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "down regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "down regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "down regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of duplicase" BROAD [GOC:TermGenie] synonym: "down regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "down regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of sequenase" RELATED [GOC:TermGenie] synonym: "down regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "down regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "down regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "down regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of duplicase" BROAD [GOC:TermGenie] synonym: "down-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "down-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of sequenase" RELATED [GOC:TermGenie] synonym: "down-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "down-regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "down-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "down-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "downregulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "downregulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "downregulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of duplicase" BROAD [GOC:TermGenie] synonym: "downregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "downregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of sequenase" RELATED [GOC:TermGenie] synonym: "downregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "downregulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "downregulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "downregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "downregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "inhibition of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "inhibition of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "inhibition of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of duplicase" BROAD [GOC:TermGenie] synonym: "inhibition of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Klenow fragment" NARROW [GOC:TermGenie] synonym: "inhibition of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sequenase" RELATED [GOC:TermGenie] synonym: "inhibition of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "inhibition of Taq Pol I" NARROW [GOC:TermGenie] synonym: "inhibition of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "inhibition of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of duplicase" BROAD [GOC:TermGenie] synonym: "negative regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "negative regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of sequenase" RELATED [GOC:TermGenie] synonym: "negative regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "negative regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "negative regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "negative regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003887 ! DNA-directed DNA polymerase activity relationship: negatively_regulates GO:0003887 ! DNA-directed DNA polymerase activity created_by: tb creation_date: 2012-04-03T11:07:18Z [Term] id: GO:1900264 name: positive regulation of DNA-directed DNA polymerase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] synonym: "activation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "activation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "activation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "activation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of duplicase" BROAD [GOC:TermGenie] synonym: "activation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "activation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of sequenase" RELATED [GOC:TermGenie] synonym: "activation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "activation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "activation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "activation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of duplicase" BROAD [GOC:TermGenie] synonym: "positive regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "positive regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of sequenase" RELATED [GOC:TermGenie] synonym: "positive regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "positive regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "positive regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "positive regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "up regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "up regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of duplicase" BROAD [GOC:TermGenie] synonym: "up regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "up regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of sequenase" RELATED [GOC:TermGenie] synonym: "up regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "up regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "up regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "up regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of duplicase" BROAD [GOC:TermGenie] synonym: "up-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "up-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of sequenase" RELATED [GOC:TermGenie] synonym: "up-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "up-regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "up-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "up-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "upregulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "upregulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of duplicase" BROAD [GOC:TermGenie] synonym: "upregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "upregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of sequenase" RELATED [GOC:TermGenie] synonym: "upregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "upregulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "upregulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "upregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity relationship: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity created_by: tb creation_date: 2012-04-03T11:07:27Z [Term] id: GO:1900265 name: regulation of substance P receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] synonym: "regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "regulation of substance P receptor ligand" NARROW [GOC:TermGenie] is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031835 ! substance P receptor binding relationship: regulates GO:0031835 ! substance P receptor binding created_by: tb creation_date: 2012-04-03T11:11:27Z [Term] id: GO:1900266 name: negative regulation of substance P receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] synonym: "down regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "down-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "downregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "inhibition of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of substance P receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "negative regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "negative regulation of substance P receptor ligand" NARROW [GOC:TermGenie] is_a: GO:1900121 ! negative regulation of receptor binding is_a: GO:1900265 ! regulation of substance P receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031835 ! substance P receptor binding relationship: negatively_regulates GO:0031835 ! substance P receptor binding created_by: tb creation_date: 2012-04-03T11:11:36Z [Term] id: GO:1900267 name: positive regulation of substance P receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] synonym: "activation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "activation of substance P receptor binding" NARROW [GOC:TermGenie] synonym: "activation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "positive regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "positive regulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "up regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "up regulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "up regulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "up-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of substance P receptor ligand" NARROW [GOC:TermGenie] synonym: "upregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of substance P receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of substance P receptor ligand" NARROW [GOC:TermGenie] is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:1900265 ! regulation of substance P receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031835 ! substance P receptor binding relationship: positively_regulates GO:0031835 ! substance P receptor binding created_by: tb creation_date: 2012-04-03T11:11:45Z [Term] id: GO:1900268 name: regulation of reverse transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reverse transcription." [GOC:TermGenie] is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001171 ! reverse transcription relationship: regulates GO:0001171 ! reverse transcription created_by: tb creation_date: 2012-04-03T11:13:26Z [Term] id: GO:1900269 name: negative regulation of reverse transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription." [GOC:TermGenie] synonym: "down regulation of reverse transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of reverse transcription" EXACT [GOC:TermGenie] synonym: "downregulation of reverse transcription" EXACT [GOC:TermGenie] synonym: "inhibition of reverse transcription" NARROW [GOC:TermGenie] is_a: GO:1900268 ! regulation of reverse transcription is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001171 ! reverse transcription relationship: negatively_regulates GO:0001171 ! reverse transcription created_by: tb creation_date: 2012-04-03T11:13:35Z [Term] id: GO:1900270 name: positive regulation of reverse transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reverse transcription." [GOC:TermGenie] synonym: "activation of reverse transcription" NARROW [GOC:TermGenie] synonym: "up regulation of reverse transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of reverse transcription" EXACT [GOC:TermGenie] synonym: "upregulation of reverse transcription" EXACT [GOC:TermGenie] is_a: GO:1900268 ! regulation of reverse transcription is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001171 ! reverse transcription relationship: positively_regulates GO:0001171 ! reverse transcription created_by: tb creation_date: 2012-04-03T11:13:43Z [Term] id: GO:1900271 name: regulation of long-term synaptic potentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "regulation of LTP" RELATED [GOC:TermGenie] is_a: GO:0048167 ! regulation of synaptic plasticity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060291 ! long-term synaptic potentiation relationship: regulates GO:0060291 ! long-term synaptic potentiation created_by: rl creation_date: 2012-04-04T07:17:13Z [Term] id: GO:1900272 name: negative regulation of long-term synaptic potentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "down regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "down regulation of LTP" RELATED [GOC:TermGenie] synonym: "down-regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "down-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of LTP" RELATED [GOC:TermGenie] synonym: "downregulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "downregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "downregulation of LTP" RELATED [GOC:TermGenie] synonym: "inhibition of long-term potentiation" BROAD [GOC:TermGenie] synonym: "inhibition of long-term synaptic potentiation" NARROW [GOC:TermGenie] synonym: "inhibition of LTP" RELATED [GOC:TermGenie] synonym: "negative regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "negative regulation of LTP" RELATED [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1900271 ! regulation of long-term synaptic potentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060291 ! long-term synaptic potentiation relationship: negatively_regulates GO:0060291 ! long-term synaptic potentiation created_by: rl creation_date: 2012-04-04T07:17:21Z [Term] id: GO:1900273 name: positive regulation of long-term synaptic potentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] synonym: "activation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "activation of long-term synaptic potentiation" NARROW [GOC:TermGenie] synonym: "activation of LTP" RELATED [GOC:TermGenie] synonym: "positive regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "positive regulation of LTP" RELATED [GOC:TermGenie] synonym: "up regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "up regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "up regulation of LTP" RELATED [GOC:TermGenie] synonym: "up-regulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "up-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of LTP" RELATED [GOC:TermGenie] synonym: "upregulation of long-term potentiation" BROAD [GOC:TermGenie] synonym: "upregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "upregulation of LTP" RELATED [GOC:TermGenie] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:1900271 ! regulation of long-term synaptic potentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060291 ! long-term synaptic potentiation relationship: positively_regulates GO:0060291 ! long-term synaptic potentiation created_by: rl creation_date: 2012-04-04T07:17:30Z [Term] id: GO:1900274 name: regulation of phospholipase C activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie] synonym: "regulation of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "regulation of phosphatidase C" RELATED [GOC:TermGenie] is_a: GO:0010517 ! regulation of phospholipase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004629 ! phospholipase C activity relationship: regulates GO:0004629 ! phospholipase C activity created_by: rl creation_date: 2012-04-04T01:19:00Z [Term] id: GO:1900275 name: negative regulation of phospholipase C activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "down regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "down regulation of phosphatidase C" RELATED [GOC:TermGenie] synonym: "down regulation of phospholipase C activity" EXACT [GOC:TermGenie] synonym: "down-regulation of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "down-regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "down-regulation of phosphatidase C" RELATED [GOC:TermGenie] synonym: "down-regulation of phospholipase C activity" EXACT [GOC:TermGenie] synonym: "downregulation of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "downregulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "downregulation of phosphatidase C" RELATED [GOC:TermGenie] synonym: "downregulation of phospholipase C activity" EXACT [GOC:TermGenie] synonym: "inhibition of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "inhibition of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "inhibition of phosphatidase C" RELATED [GOC:TermGenie] synonym: "inhibition of phospholipase C activity" NARROW [GOC:TermGenie] synonym: "negative regulation of lecithinase C activity" RELATED [GOC:TermGenie] synonym: "negative regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] synonym: "negative regulation of phosphatidase C" RELATED [GOC:TermGenie] is_a: GO:0010519 ! negative regulation of phospholipase activity is_a: GO:1900274 ! regulation of phospholipase C activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004629 ! phospholipase C activity relationship: negatively_regulates GO:0004629 ! phospholipase C activity created_by: rl creation_date: 2012-04-04T01:19:10Z [Term] id: GO:1900276 name: regulation of proteinase activated receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001648 ! proteinase activated receptor activity relationship: regulates GO:0001648 ! proteinase activated receptor activity created_by: rl creation_date: 2012-04-04T01:31:20Z [Term] id: GO:1900277 name: negative regulation of proteinase activated receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] synonym: "inhibition of proteinase activated receptor activity" NARROW [GOC:TermGenie] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:1900276 ! regulation of proteinase activated receptor activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001648 ! proteinase activated receptor activity relationship: negatively_regulates GO:0001648 ! proteinase activated receptor activity created_by: rl creation_date: 2012-04-04T01:31:29Z [Term] id: GO:1900278 name: positive regulation of proteinase activated receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] synonym: "activation of proteinase activated receptor activity" NARROW [GOC:TermGenie] synonym: "up regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:1900276 ! regulation of proteinase activated receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001648 ! proteinase activated receptor activity relationship: positively_regulates GO:0001648 ! proteinase activated receptor activity created_by: rl creation_date: 2012-04-04T01:31:37Z [Term] id: GO:1900279 name: regulation of CD4-positive, alpha-beta T cell costimulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] synonym: "regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000523 ! regulation of T cell costimulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation relationship: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation created_by: rl creation_date: 2012-04-04T08:56:15Z [Term] id: GO:1900280 name: negative regulation of CD4-positive, alpha-beta T cell costimulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] synonym: "down regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] synonym: "down-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] synonym: "downregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] synonym: "inhibition of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie] synonym: "negative regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation is_a: GO:2000524 ! negative regulation of T cell costimulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation relationship: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation created_by: rl creation_date: 2012-04-04T08:56:26Z [Term] id: GO:1900281 name: positive regulation of CD4-positive, alpha-beta T cell costimulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] synonym: "activation of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie] synonym: "positive regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] synonym: "up regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] synonym: "up-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] synonym: "upregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000525 ! positive regulation of T cell costimulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation relationship: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation created_by: rl creation_date: 2012-04-04T08:56:45Z [Term] id: GO:1900282 name: regulation of cellobiose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of cellobiose catabolism" EXACT [GOC:TermGenie] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:2000930 ! regulation of cellobiose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000892 ! cellobiose catabolic process relationship: regulates GO:2000892 ! cellobiose catabolic process created_by: tt creation_date: 2012-04-05T12:28:50Z [Term] id: GO:1900283 name: negative regulation of cellobiose catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of cellobiose catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellobiose catabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of cellobiose catabolism" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:1900282 ! regulation of cellobiose catabolic process is_a: GO:2000931 ! negative regulation of cellobiose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000892 ! cellobiose catabolic process relationship: negatively_regulates GO:2000892 ! cellobiose catabolic process created_by: tt creation_date: 2012-04-05T12:29:00Z [Term] id: GO:1900284 name: positive regulation of cellobiose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of cellobiose catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellobiose catabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellobiose catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellobiose catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellobiose catabolism" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:1900282 ! regulation of cellobiose catabolic process is_a: GO:2000932 ! positive regulation of cellobiose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000892 ! cellobiose catabolic process relationship: positively_regulates GO:2000892 ! cellobiose catabolic process created_by: tt creation_date: 2012-04-05T12:29:09Z [Term] id: GO:1900285 name: regulation of cellotriose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001096 ! cellotriose transport relationship: regulates GO:2001096 ! cellotriose transport created_by: tt creation_date: 2012-04-05T05:56:46Z [Term] id: GO:1900286 name: negative regulation of cellotriose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of cellotriose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cellotriose transport" EXACT [GOC:TermGenie] synonym: "downregulation of cellotriose transport" EXACT [GOC:TermGenie] synonym: "inhibition of cellotriose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900285 ! regulation of cellotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001096 ! cellotriose transport relationship: negatively_regulates GO:2001096 ! cellotriose transport created_by: tt creation_date: 2012-04-05T05:56:56Z [Term] id: GO:1900287 name: positive regulation of cellotriose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of cellotriose transport" NARROW [GOC:TermGenie] synonym: "up regulation of cellotriose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cellotriose transport" EXACT [GOC:TermGenie] synonym: "upregulation of cellotriose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900285 ! regulation of cellotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001096 ! cellotriose transport relationship: positively_regulates GO:2001096 ! cellotriose transport created_by: tt creation_date: 2012-04-05T05:57:05Z [Term] id: GO:1900288 name: regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process relationship: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process created_by: tt creation_date: 2012-04-05T06:02:41Z [Term] id: GO:1900289 name: negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "negative regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process relationship: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process created_by: tt creation_date: 2012-04-05T06:02:51Z [Term] id: GO:1900290 name: positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie] synonym: "activation of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie] synonym: "activation of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie] synonym: "activation of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie] synonym: "activation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "positive regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process relationship: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process created_by: tt creation_date: 2012-04-05T06:02:59Z [Term] id: GO:1900291 name: regulation of galactotriose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001093 ! galactotriose transport relationship: regulates GO:2001093 ! galactotriose transport created_by: tt creation_date: 2012-04-05T07:25:58Z [Term] id: GO:1900292 name: negative regulation of galactotriose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of galactotriose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of galactotriose transport" EXACT [GOC:TermGenie] synonym: "downregulation of galactotriose transport" EXACT [GOC:TermGenie] synonym: "inhibition of galactotriose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900291 ! regulation of galactotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001093 ! galactotriose transport relationship: negatively_regulates GO:2001093 ! galactotriose transport created_by: tt creation_date: 2012-04-05T07:26:08Z [Term] id: GO:1900293 name: positive regulation of galactotriose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of galactotriose transport" NARROW [GOC:TermGenie] synonym: "up regulation of galactotriose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of galactotriose transport" EXACT [GOC:TermGenie] synonym: "upregulation of galactotriose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900291 ! regulation of galactotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001093 ! galactotriose transport relationship: positively_regulates GO:2001093 ! galactotriose transport created_by: tt creation_date: 2012-04-05T07:26:28Z [Term] id: GO:1900294 name: regulation of heptasaccharide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001104 ! heptasaccharide transport relationship: regulates GO:2001104 ! heptasaccharide transport created_by: tt creation_date: 2012-04-05T07:40:40Z [Term] id: GO:1900295 name: negative regulation of heptasaccharide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of heptasaccharide transport" EXACT [GOC:TermGenie] synonym: "down-regulation of heptasaccharide transport" EXACT [GOC:TermGenie] synonym: "downregulation of heptasaccharide transport" EXACT [GOC:TermGenie] synonym: "inhibition of heptasaccharide transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900294 ! regulation of heptasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001104 ! heptasaccharide transport relationship: negatively_regulates GO:2001104 ! heptasaccharide transport created_by: tt creation_date: 2012-04-05T07:40:49Z [Term] id: GO:1900296 name: positive regulation of heptasaccharide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of heptasaccharide transport" NARROW [GOC:TermGenie] synonym: "up regulation of heptasaccharide transport" EXACT [GOC:TermGenie] synonym: "up-regulation of heptasaccharide transport" EXACT [GOC:TermGenie] synonym: "upregulation of heptasaccharide transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900294 ! regulation of heptasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001104 ! heptasaccharide transport relationship: positively_regulates GO:2001104 ! heptasaccharide transport created_by: tt creation_date: 2012-04-05T07:40:58Z [Term] id: GO:1900297 name: regulation of hexasaccharide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001102 ! hexasaccharide transport relationship: regulates GO:2001102 ! hexasaccharide transport created_by: tt creation_date: 2012-04-05T07:44:31Z [Term] id: GO:1900298 name: negative regulation of hexasaccharide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of hexasaccharide transport" EXACT [GOC:TermGenie] synonym: "down-regulation of hexasaccharide transport" EXACT [GOC:TermGenie] synonym: "downregulation of hexasaccharide transport" EXACT [GOC:TermGenie] synonym: "inhibition of hexasaccharide transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900297 ! regulation of hexasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001102 ! hexasaccharide transport relationship: negatively_regulates GO:2001102 ! hexasaccharide transport created_by: tt creation_date: 2012-04-05T07:44:40Z [Term] id: GO:1900299 name: positive regulation of hexasaccharide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of hexasaccharide transport" NARROW [GOC:TermGenie] synonym: "up regulation of hexasaccharide transport" EXACT [GOC:TermGenie] synonym: "up-regulation of hexasaccharide transport" EXACT [GOC:TermGenie] synonym: "upregulation of hexasaccharide transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900297 ! regulation of hexasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001102 ! hexasaccharide transport relationship: positively_regulates GO:2001102 ! hexasaccharide transport created_by: tt creation_date: 2012-04-05T07:44:49Z [Term] id: GO:1900300 name: regulation of laminarabiose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001086 ! laminarabiose transport relationship: regulates GO:2001086 ! laminarabiose transport created_by: tt creation_date: 2012-04-05T07:57:19Z [Term] id: GO:1900301 name: negative regulation of laminarabiose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of laminarabiose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of laminarabiose transport" EXACT [GOC:TermGenie] synonym: "downregulation of laminarabiose transport" EXACT [GOC:TermGenie] synonym: "inhibition of laminarabiose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900300 ! regulation of laminarabiose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001086 ! laminarabiose transport relationship: negatively_regulates GO:2001086 ! laminarabiose transport created_by: tt creation_date: 2012-04-05T07:57:28Z [Term] id: GO:1900302 name: positive regulation of laminarabiose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of laminarabiose transport" NARROW [GOC:TermGenie] synonym: "up regulation of laminarabiose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of laminarabiose transport" EXACT [GOC:TermGenie] synonym: "upregulation of laminarabiose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900300 ! regulation of laminarabiose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001086 ! laminarabiose transport relationship: positively_regulates GO:2001086 ! laminarabiose transport created_by: tt creation_date: 2012-04-05T07:57:37Z [Term] id: GO:1900303 name: regulation of laminaritriose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001097 ! laminaritriose transport relationship: regulates GO:2001097 ! laminaritriose transport created_by: tt creation_date: 2012-04-05T07:57:49Z [Term] id: GO:1900304 name: negative regulation of laminaritriose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of laminaritriose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of laminaritriose transport" EXACT [GOC:TermGenie] synonym: "downregulation of laminaritriose transport" EXACT [GOC:TermGenie] synonym: "inhibition of laminaritriose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900303 ! regulation of laminaritriose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001097 ! laminaritriose transport relationship: negatively_regulates GO:2001097 ! laminaritriose transport created_by: tt creation_date: 2012-04-05T07:57:58Z [Term] id: GO:1900305 name: positive regulation of laminaritriose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of laminaritriose transport" NARROW [GOC:TermGenie] synonym: "up regulation of laminaritriose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of laminaritriose transport" EXACT [GOC:TermGenie] synonym: "upregulation of laminaritriose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900303 ! regulation of laminaritriose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001097 ! laminaritriose transport relationship: positively_regulates GO:2001097 ! laminaritriose transport created_by: tt creation_date: 2012-04-05T07:58:06Z [Term] id: GO:1900306 name: regulation of maltoheptaose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1900294 ! regulation of heptasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001105 ! maltoheptaose transport relationship: regulates GO:2001105 ! maltoheptaose transport created_by: tt creation_date: 2012-04-05T07:58:18Z [Term] id: GO:1900307 name: negative regulation of maltoheptaose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltoheptaose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltoheptaose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltoheptaose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltoheptaose transport" NARROW [GOC:TermGenie] is_a: GO:1900295 ! negative regulation of heptasaccharide transport is_a: GO:1900306 ! regulation of maltoheptaose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001105 ! maltoheptaose transport relationship: negatively_regulates GO:2001105 ! maltoheptaose transport created_by: tt creation_date: 2012-04-05T07:58:27Z [Term] id: GO:1900308 name: positive regulation of maltoheptaose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltoheptaose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltoheptaose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltoheptaose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltoheptaose transport" EXACT [GOC:TermGenie] is_a: GO:1900296 ! positive regulation of heptasaccharide transport is_a: GO:1900306 ! regulation of maltoheptaose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001105 ! maltoheptaose transport relationship: positively_regulates GO:2001105 ! maltoheptaose transport created_by: tt creation_date: 2012-04-05T07:58:35Z [Term] id: GO:1900309 name: regulation of maltoheptaose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] is_a: GO:0006109 ! regulation of carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001122 ! maltoheptaose metabolic process relationship: regulates GO:2001122 ! maltoheptaose metabolic process created_by: tt creation_date: 2012-04-05T07:58:48Z [Term] id: GO:1900310 name: negative regulation of maltoheptaose metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of maltoheptaose metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of maltoheptaose metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1900309 ! regulation of maltoheptaose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001122 ! maltoheptaose metabolic process relationship: negatively_regulates GO:2001122 ! maltoheptaose metabolic process created_by: tt creation_date: 2012-04-05T07:58:58Z [Term] id: GO:1900311 name: positive regulation of maltoheptaose metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltoheptaose metabolic process" NARROW [GOC:TermGenie] synonym: "activation of maltoheptaose metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900309 ! regulation of maltoheptaose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001122 ! maltoheptaose metabolic process relationship: positively_regulates GO:2001122 ! maltoheptaose metabolic process created_by: tt creation_date: 2012-04-05T07:59:06Z [Term] id: GO:1900312 name: regulation of maltohexaose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1900297 ! regulation of hexasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001103 ! maltohexaose transport relationship: regulates GO:2001103 ! maltohexaose transport created_by: tt creation_date: 2012-04-05T07:59:18Z [Term] id: GO:1900313 name: negative regulation of maltohexaose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltohexaose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltohexaose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltohexaose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltohexaose transport" NARROW [GOC:TermGenie] is_a: GO:1900298 ! negative regulation of hexasaccharide transport is_a: GO:1900312 ! regulation of maltohexaose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001103 ! maltohexaose transport relationship: negatively_regulates GO:2001103 ! maltohexaose transport created_by: tt creation_date: 2012-04-05T07:59:26Z [Term] id: GO:1900314 name: positive regulation of maltohexaose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltohexaose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltohexaose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltohexaose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltohexaose transport" EXACT [GOC:TermGenie] is_a: GO:1900299 ! positive regulation of hexasaccharide transport is_a: GO:1900312 ! regulation of maltohexaose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001103 ! maltohexaose transport relationship: positively_regulates GO:2001103 ! maltohexaose transport created_by: tt creation_date: 2012-04-05T07:59:35Z [Term] id: GO:1900315 name: regulation of maltopentaose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1900360 ! regulation of pentasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001101 ! maltopentaose transport relationship: regulates GO:2001101 ! maltopentaose transport created_by: tt creation_date: 2012-04-05T07:59:47Z [Term] id: GO:1900316 name: negative regulation of maltopentaose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltopentaose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltopentaose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltopentaose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltopentaose transport" NARROW [GOC:TermGenie] is_a: GO:1900315 ! regulation of maltopentaose transport is_a: GO:1900361 ! negative regulation of pentasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001101 ! maltopentaose transport relationship: negatively_regulates GO:2001101 ! maltopentaose transport created_by: tt creation_date: 2012-04-05T07:59:56Z [Term] id: GO:1900317 name: positive regulation of maltopentaose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltopentaose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltopentaose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltopentaose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltopentaose transport" EXACT [GOC:TermGenie] is_a: GO:1900315 ! regulation of maltopentaose transport is_a: GO:1900362 ! positive regulation of pentasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001101 ! maltopentaose transport relationship: positively_regulates GO:2001101 ! maltopentaose transport created_by: tt creation_date: 2012-04-05T08:00:04Z [Term] id: GO:1900318 name: regulation of methane biosynthetic process from dimethylamine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001129 ! methane biosynthetic process from dimethylamine relationship: regulates GO:2001129 ! methane biosynthetic process from dimethylamine created_by: tt creation_date: 2012-04-06T01:43:21Z [Term] id: GO:1900319 name: negative regulation of methane biosynthetic process from dimethylamine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine relationship: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine created_by: tt creation_date: 2012-04-06T01:43:31Z [Term] id: GO:1900320 name: positive regulation of methane biosynthetic process from dimethylamine namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine relationship: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine created_by: tt creation_date: 2012-04-06T01:43:40Z [Term] id: GO:1900321 name: regulation of maltotetraose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001099 ! maltotetraose transport relationship: regulates GO:2001099 ! maltotetraose transport created_by: tt creation_date: 2012-04-06T01:45:36Z [Term] id: GO:1900322 name: negative regulation of maltotetraose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltotetraose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltotetraose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltotetraose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltotetraose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900321 ! regulation of maltotetraose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001099 ! maltotetraose transport relationship: negatively_regulates GO:2001099 ! maltotetraose transport created_by: tt creation_date: 2012-04-06T01:45:45Z [Term] id: GO:1900323 name: positive regulation of maltotetraose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltotetraose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltotetraose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltotetraose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltotetraose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900321 ! regulation of maltotetraose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001099 ! maltotetraose transport relationship: positively_regulates GO:2001099 ! maltotetraose transport created_by: tt creation_date: 2012-04-06T01:45:54Z [Term] id: GO:1900324 name: regulation of maltotriulose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001090 ! maltotriulose transport relationship: regulates GO:2001090 ! maltotriulose transport created_by: tt creation_date: 2012-04-06T01:48:06Z [Term] id: GO:1900325 name: negative regulation of maltotriulose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of maltotriulose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltotriulose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltotriulose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltotriulose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900324 ! regulation of maltotriulose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001090 ! maltotriulose transport relationship: negatively_regulates GO:2001090 ! maltotriulose transport created_by: tt creation_date: 2012-04-06T01:48:16Z [Term] id: GO:1900326 name: positive regulation of maltotriulose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of maltotriulose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltotriulose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltotriulose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltotriulose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900324 ! regulation of maltotriulose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001090 ! maltotriulose transport relationship: positively_regulates GO:2001090 ! maltotriulose transport created_by: tt creation_date: 2012-04-06T01:48:25Z [Term] id: GO:1900327 name: regulation of mannotriose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001095 ! mannotriose transport relationship: regulates GO:2001095 ! mannotriose transport created_by: tt creation_date: 2012-04-06T01:50:05Z [Term] id: GO:1900328 name: negative regulation of mannotriose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of mannotriose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of mannotriose transport" EXACT [GOC:TermGenie] synonym: "downregulation of mannotriose transport" EXACT [GOC:TermGenie] synonym: "inhibition of mannotriose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900327 ! regulation of mannotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001095 ! mannotriose transport relationship: negatively_regulates GO:2001095 ! mannotriose transport created_by: tt creation_date: 2012-04-06T01:50:13Z [Term] id: GO:1900329 name: positive regulation of mannotriose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of mannotriose transport" NARROW [GOC:TermGenie] synonym: "up regulation of mannotriose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of mannotriose transport" EXACT [GOC:TermGenie] synonym: "upregulation of mannotriose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900327 ! regulation of mannotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001095 ! mannotriose transport relationship: positively_regulates GO:2001095 ! mannotriose transport created_by: tt creation_date: 2012-04-06T01:50:22Z [Term] id: GO:1900330 name: regulation of methane biosynthetic process from trimethylamine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001130 ! methane biosynthetic process from trimethylamine relationship: regulates GO:2001130 ! methane biosynthetic process from trimethylamine created_by: tt creation_date: 2012-04-06T01:53:03Z [Term] id: GO:1900331 name: negative regulation of methane biosynthetic process from trimethylamine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine relationship: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine created_by: tt creation_date: 2012-04-06T01:53:12Z [Term] id: GO:1900332 name: positive regulation of methane biosynthetic process from trimethylamine namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine relationship: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine created_by: tt creation_date: 2012-04-06T01:53:20Z [Term] id: GO:1900333 name: regulation of methane biosynthetic process from 3-(methylthio)propionic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid relationship: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid created_by: tt creation_date: 2012-04-06T01:56:13Z [Term] id: GO:1900334 name: negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie] is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid relationship: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid created_by: tt creation_date: 2012-04-06T01:56:23Z [Term] id: GO:1900335 name: positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid relationship: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid created_by: tt creation_date: 2012-04-06T01:56:31Z [Term] id: GO:1900336 name: regulation of methane biosynthetic process from carbon monoxide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide relationship: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide created_by: tt creation_date: 2012-04-06T02:03:15Z [Term] id: GO:1900337 name: negative regulation of methane biosynthetic process from carbon monoxide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie] is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide relationship: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide created_by: tt creation_date: 2012-04-06T02:03:24Z [Term] id: GO:1900338 name: positive regulation of methane biosynthetic process from carbon monoxide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide relationship: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide created_by: tt creation_date: 2012-04-06T02:03:33Z [Term] id: GO:1900339 name: regulation of methane biosynthetic process from formic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001127 ! methane biosynthetic process from formic acid relationship: regulates GO:2001127 ! methane biosynthetic process from formic acid created_by: tt creation_date: 2012-04-06T02:04:53Z [Term] id: GO:1900340 name: negative regulation of methane biosynthetic process from formic acid namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie] is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid relationship: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid created_by: tt creation_date: 2012-04-06T02:05:03Z [Term] id: GO:1900341 name: positive regulation of methane biosynthetic process from formic acid namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid relationship: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid created_by: tt creation_date: 2012-04-06T02:05:11Z [Term] id: GO:1900342 name: regulation of methane biosynthetic process from dimethyl sulfide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide relationship: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide created_by: tt creation_date: 2012-04-06T02:06:38Z [Term] id: GO:1900343 name: negative regulation of methane biosynthetic process from dimethyl sulfide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie] is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide relationship: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide created_by: tt creation_date: 2012-04-06T02:06:47Z [Term] id: GO:1900344 name: positive regulation of methane biosynthetic process from dimethyl sulfide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide relationship: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide created_by: tt creation_date: 2012-04-06T02:06:56Z [Term] id: GO:1900345 name: regulation of methane biosynthetic process from methanethiol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001133 ! methane biosynthetic process from methanethiol relationship: regulates GO:2001133 ! methane biosynthetic process from methanethiol created_by: tt creation_date: 2012-04-06T02:09:49Z [Term] id: GO:1900346 name: negative regulation of methane biosynthetic process from methanethiol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie] is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol relationship: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol created_by: tt creation_date: 2012-04-06T02:09:58Z [Term] id: GO:1900347 name: positive regulation of methane biosynthetic process from methanethiol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol relationship: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol created_by: tt creation_date: 2012-04-06T02:10:06Z [Term] id: GO:1900348 name: regulation of methane biosynthetic process from methylamine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001128 ! methane biosynthetic process from methylamine relationship: regulates GO:2001128 ! methane biosynthetic process from methylamine created_by: tt creation_date: 2012-04-06T02:11:54Z [Term] id: GO:1900349 name: negative regulation of methane biosynthetic process from methylamine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] synonym: "down-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] synonym: "downregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] synonym: "inhibition of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine is_a: GO:1901578 ! negative regulation of alkane biosynthetic process is_a: GO:1901856 ! negative regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine relationship: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine created_by: tt creation_date: 2012-04-06T02:12:04Z [Term] id: GO:1900350 name: positive regulation of methane biosynthetic process from methylamine namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie] synonym: "up regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] synonym: "up-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] synonym: "upregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine is_a: GO:1901579 ! positive regulation of alkane biosynthetic process is_a: GO:1901857 ! positive regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine relationship: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine created_by: tt creation_date: 2012-04-06T02:12:12Z [Term] id: GO:1900351 name: regulation of methanofuran biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:1900354 ! regulation of methanofuran metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001120 ! methanofuran biosynthetic process relationship: regulates GO:2001120 ! methanofuran biosynthetic process created_by: tt creation_date: 2012-04-06T02:13:51Z [Term] id: GO:1900352 name: negative regulation of methanofuran biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of methanofuran biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045863 ! negative regulation of pteridine metabolic process is_a: GO:1900351 ! regulation of methanofuran biosynthetic process is_a: GO:1900355 ! negative regulation of methanofuran metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001120 ! methanofuran biosynthetic process relationship: negatively_regulates GO:2001120 ! methanofuran biosynthetic process created_by: tt creation_date: 2012-04-06T02:14:00Z [Term] id: GO:1900353 name: positive regulation of methanofuran biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of methanofuran biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045864 ! positive regulation of pteridine metabolic process is_a: GO:1900351 ! regulation of methanofuran biosynthetic process is_a: GO:1900356 ! positive regulation of methanofuran metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001120 ! methanofuran biosynthetic process relationship: positively_regulates GO:2001120 ! methanofuran biosynthetic process created_by: tt creation_date: 2012-04-06T02:14:09Z [Term] id: GO:1900354 name: regulation of methanofuran metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of methanofuran metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001119 ! methanofuran metabolic process relationship: regulates GO:2001119 ! methanofuran metabolic process created_by: tt creation_date: 2012-04-06T02:15:44Z [Term] id: GO:1900355 name: negative regulation of methanofuran metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of methanofuran metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of methanofuran metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900354 ! regulation of methanofuran metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001119 ! methanofuran metabolic process relationship: negatively_regulates GO:2001119 ! methanofuran metabolic process created_by: tt creation_date: 2012-04-06T02:15:53Z [Term] id: GO:1900356 name: positive regulation of methanofuran metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methanofuran metabolic process" NARROW [GOC:TermGenie] synonym: "activation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methanofuran metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of methanofuran metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of methanofuran metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900354 ! regulation of methanofuran metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001119 ! methanofuran metabolic process relationship: positively_regulates GO:2001119 ! methanofuran metabolic process created_by: tt creation_date: 2012-04-06T02:16:01Z [Term] id: GO:1900357 name: regulation of nigerotriose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001091 ! nigerotriose transport relationship: regulates GO:2001091 ! nigerotriose transport created_by: tt creation_date: 2012-04-06T02:18:06Z [Term] id: GO:1900358 name: negative regulation of nigerotriose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of nigerotriose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of nigerotriose transport" EXACT [GOC:TermGenie] synonym: "downregulation of nigerotriose transport" EXACT [GOC:TermGenie] synonym: "inhibition of nigerotriose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900357 ! regulation of nigerotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001091 ! nigerotriose transport relationship: negatively_regulates GO:2001091 ! nigerotriose transport created_by: tt creation_date: 2012-04-06T02:18:21Z [Term] id: GO:1900359 name: positive regulation of nigerotriose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of nigerotriose transport" NARROW [GOC:TermGenie] synonym: "up regulation of nigerotriose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of nigerotriose transport" EXACT [GOC:TermGenie] synonym: "upregulation of nigerotriose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900357 ! regulation of nigerotriose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001091 ! nigerotriose transport relationship: positively_regulates GO:2001091 ! nigerotriose transport created_by: tt creation_date: 2012-04-06T02:18:29Z [Term] id: GO:1900360 name: regulation of pentasaccharide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001100 ! pentasaccharide transport relationship: regulates GO:2001100 ! pentasaccharide transport created_by: tt creation_date: 2012-04-06T02:19:27Z [Term] id: GO:1900361 name: negative regulation of pentasaccharide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of pentasaccharide transport" EXACT [GOC:TermGenie] synonym: "down-regulation of pentasaccharide transport" EXACT [GOC:TermGenie] synonym: "downregulation of pentasaccharide transport" EXACT [GOC:TermGenie] synonym: "inhibition of pentasaccharide transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1900360 ! regulation of pentasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001100 ! pentasaccharide transport relationship: negatively_regulates GO:2001100 ! pentasaccharide transport created_by: tt creation_date: 2012-04-06T02:19:36Z [Term] id: GO:1900362 name: positive regulation of pentasaccharide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of pentasaccharide transport" NARROW [GOC:TermGenie] synonym: "up regulation of pentasaccharide transport" EXACT [GOC:TermGenie] synonym: "up-regulation of pentasaccharide transport" EXACT [GOC:TermGenie] synonym: "upregulation of pentasaccharide transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1900360 ! regulation of pentasaccharide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001100 ! pentasaccharide transport relationship: positively_regulates GO:2001100 ! pentasaccharide transport created_by: tt creation_date: 2012-04-06T02:19:44Z [Term] id: GO:1900363 name: regulation of mRNA polyadenylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] synonym: "regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] is_a: GO:0031440 ! regulation of mRNA 3'-end processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006378 ! mRNA polyadenylation relationship: regulates GO:0006378 ! mRNA polyadenylation created_by: pr creation_date: 2012-04-12T04:36:21Z [Term] id: GO:1900364 name: negative regulation of mRNA polyadenylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] synonym: "down regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "down regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "down-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "down-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "downregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "downregulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "inhibition of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA polyadenylation" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA polyadenylylation" NARROW [GOC:TermGenie] synonym: "negative regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing is_a: GO:1900363 ! regulation of mRNA polyadenylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006378 ! mRNA polyadenylation relationship: negatively_regulates GO:0006378 ! mRNA polyadenylation created_by: pr creation_date: 2012-04-12T04:36:31Z [Term] id: GO:1900365 name: positive regulation of mRNA polyadenylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] synonym: "activation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "activation of mRNA polyadenylation" NARROW [GOC:TermGenie] synonym: "activation of mRNA polyadenylylation" NARROW [GOC:TermGenie] synonym: "positive regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "up regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "up regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "up-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "up-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] synonym: "upregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] synonym: "upregulation of mRNA polyadenylation" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing is_a: GO:1900363 ! regulation of mRNA polyadenylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006378 ! mRNA polyadenylation relationship: positively_regulates GO:0006378 ! mRNA polyadenylation created_by: pr creation_date: 2012-04-12T04:36:39Z [Term] id: GO:1900366 name: negative regulation of defense response to insect namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie] synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "susceptibility to insect" RELATED [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002213 ! defense response to insect relationship: negatively_regulates GO:0002213 ! defense response to insect created_by: dhl creation_date: 2012-04-12T04:44:00Z [Term] id: GO:1900367 name: positive regulation of defense response to insect namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "activation of defense response to insect" NARROW [GOC:TermGenie] synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002213 ! defense response to insect relationship: positively_regulates GO:0002213 ! defense response to insect created_by: dhl creation_date: 2012-04-12T04:44:10Z [Term] id: GO:1900368 name: regulation of RNA interference namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "regulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060147 ! regulation of posttranscriptional gene silencing is_a: GO:0060966 ! regulation of gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016246 ! RNA interference relationship: regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:28:39Z [Term] id: GO:1900369 name: negative regulation of RNA interference namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "down regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "down regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "down regulation of RNAi" EXACT [GOC:TermGenie] synonym: "down-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "down-regulation of RNAi" EXACT [GOC:TermGenie] synonym: "downregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "downregulation of RNA interference" EXACT [GOC:TermGenie] synonym: "downregulation of RNAi" EXACT [GOC:TermGenie] synonym: "inhibition of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "inhibition of RNA interference" NARROW [GOC:TermGenie] synonym: "inhibition of RNAi" EXACT [GOC:TermGenie] synonym: "negative regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "negative regulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing is_a: GO:0060967 ! negative regulation of gene silencing by RNA is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016246 ! RNA interference relationship: negatively_regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:28:50Z [Term] id: GO:1900370 name: positive regulation of RNA interference namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] synonym: "activation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "activation of RNA interference" NARROW [GOC:TermGenie] synonym: "activation of RNAi" EXACT [GOC:TermGenie] synonym: "positive regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "positive regulation of RNAi" EXACT [GOC:TermGenie] synonym: "up regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "up regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "up regulation of RNAi" EXACT [GOC:TermGenie] synonym: "up-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA interference" EXACT [GOC:TermGenie] synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie] synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie] synonym: "upregulation of RNAi" EXACT [GOC:TermGenie] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016246 ! RNA interference relationship: positively_regulates GO:0016246 ! RNA interference created_by: kmv creation_date: 2012-04-13T08:29:00Z [Term] id: GO:1900371 name: regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:07Z [Term] id: GO:1900372 name: negative regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:27Z [Term] id: GO:1900373 name: positive regulation of purine nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-17T12:32:37Z [Term] id: GO:1900374 name: obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:go_curators, GOC:TermGenie, PMID:8804308] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "stimulation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-04-17T12:39:56Z [Term] id: GO:1900375 name: obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process." [GOC:go_curators, GOC:TermGenie, PMID:2004420] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-04-17T12:45:48Z [Term] id: GO:1900376 name: regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044550 ! secondary metabolite biosynthetic process relationship: regulates GO:0044550 ! secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:23Z [Term] id: GO:1900377 name: negative regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process relationship: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:32Z [Term] id: GO:1900378 name: positive regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process relationship: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:41Z [Term] id: GO:1900379 name: regulation of asperthecin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036184 ! asperthecin biosynthetic process relationship: regulates GO:0036184 ! asperthecin biosynthetic process created_by: di creation_date: 2012-04-17T01:58:27Z [Term] id: GO:1900380 name: negative regulation of asperthecin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "down regulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "downregulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of asperthecin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of asperthecin formation" EXACT [GOC:TermGenie] synonym: "inhibition of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900379 ! regulation of asperthecin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036184 ! asperthecin biosynthetic process relationship: negatively_regulates GO:0036184 ! asperthecin biosynthetic process created_by: di creation_date: 2012-04-17T01:58:37Z [Term] id: GO:1900381 name: positive regulation of asperthecin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of asperthecin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "activation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "up regulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of asperthecin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900379 ! regulation of asperthecin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036184 ! asperthecin biosynthetic process relationship: positively_regulates GO:0036184 ! asperthecin biosynthetic process created_by: di creation_date: 2012-04-17T01:58:45Z [Term] id: GO:1900382 name: obsolete regulation of thiamine biosynthetic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of thiamine biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16874521] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of thiamin biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of thiamine anabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of thiamine biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of thiamine formation by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of thiamine synthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-17T04:05:24Z [Term] id: GO:1900383 name: regulation of synaptic plasticity by receptor localization to synapse namespace: biological_process def: "Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse." [GOC:kmv, GOC:TermGenie, PMID:22464329] synonym: "regulation of synaptic plasticity by receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0097120 ! receptor localization to synapse created_by: kmv creation_date: 2012-04-17T04:44:37Z [Term] id: GO:1900384 name: regulation of flavonol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051555 ! flavonol biosynthetic process relationship: regulates GO:0051555 ! flavonol biosynthetic process created_by: tb creation_date: 2012-04-17T10:22:49Z [Term] id: GO:1900385 name: negative regulation of flavonol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] synonym: "down regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of flavonol biosynthetic process" NARROW [GOC:TermGenie] is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process is_a: GO:1900384 ! regulation of flavonol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051555 ! flavonol biosynthetic process relationship: negatively_regulates GO:0051555 ! flavonol biosynthetic process created_by: tb creation_date: 2012-04-17T10:22:59Z [Term] id: GO:1900386 name: positive regulation of flavonol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] synonym: "activation of flavonol biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process is_a: GO:1900384 ! regulation of flavonol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051555 ! flavonol biosynthetic process relationship: positively_regulates GO:0051555 ! flavonol biosynthetic process created_by: tb creation_date: 2012-04-17T10:23:09Z [Term] id: GO:1900387 name: negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion." [GOC:BHF, GOC:TermGenie, PMID:15737616] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0022408 ! negative regulation of cell-cell adhesion intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0098609 ! cell-cell adhesion created_by: pr creation_date: 2012-04-18T12:01:19Z [Term] id: GO:1900388 name: obsolete regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of vesicle-mediated transport." [GOC:mah, GOC:TermGenie, PMID:18622392] comment: This term was made obsolete because there is no evidence that vesicle-mediated transport is regulated transcriptionally. synonym: "regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter" EXACT [] is_obsolete: true created_by: mah creation_date: 2012-04-18T03:52:29Z [Term] id: GO:1900389 name: obsolete regulation of glucose import by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of glucose import." [GOC:mah, GOC:TermGenie, PMID:18622392] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of glucose uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-18T03:52:43Z [Term] id: GO:1900391 name: obsolete regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cAMP-mediated signaling." [GOC:mah, GOC:TermGenie, PMID:15448137] comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter. See https://github.com/geneontology/go-ontology/issues/14279 synonym: "regulation of cAMP-mediated signalling by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-18T04:19:39Z [Term] id: GO:1900392 name: obsolete regulation of transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport." [GOC:mah, GOC:TermGenie, PMID:17446861] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: mah creation_date: 2012-04-18T04:20:25Z [Term] id: GO:1900394 name: regulation of kojic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "regulation of kojic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001317 ! kojic acid biosynthetic process relationship: regulates GO:2001317 ! kojic acid biosynthetic process created_by: di creation_date: 2012-04-18T04:19:53Z [Term] id: GO:1900395 name: negative regulation of kojic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "down regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "down regulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "down-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "downregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "downregulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "inhibition of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "inhibition of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of kojic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of kojic acid formation" EXACT [GOC:TermGenie] synonym: "inhibition of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "negative regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of kojic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900394 ! regulation of kojic acid biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001317 ! kojic acid biosynthetic process relationship: negatively_regulates GO:2001317 ! kojic acid biosynthetic process created_by: di creation_date: 2012-04-18T04:20:03Z [Term] id: GO:1900396 name: positive regulation of kojic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "activation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "activation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "activation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "activation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "activation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of kojic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "activation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "positive regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "up regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "up regulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "up-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of kojic acid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of C6H6O4 formation" RELATED [GOC:TermGenie] synonym: "upregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of kojic acid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of kojic acid formation" EXACT [GOC:TermGenie] synonym: "upregulation of kojic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900394 ! regulation of kojic acid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001317 ! kojic acid biosynthetic process relationship: positively_regulates GO:2001317 ! kojic acid biosynthetic process created_by: di creation_date: 2012-04-18T04:20:11Z [Term] id: GO:1900397 name: regulation of pyrimidine nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] synonym: "regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process relationship: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process created_by: jh creation_date: 2012-04-19T01:05:31Z [Term] id: GO:1900398 name: negative regulation of pyrimidine nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] synonym: "down regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "downregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "inhibition of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process relationship: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process created_by: jh creation_date: 2012-04-19T01:05:41Z [Term] id: GO:1900399 name: positive regulation of pyrimidine nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] synonym: "activation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "activation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "activation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process relationship: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process created_by: jh creation_date: 2012-04-19T01:05:50Z [Term] id: GO:1900400 name: regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:1900393 def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import." [GOC:mah, GOC:TermGenie, PMID:18622392] synonym: "regulation of iron import by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of iron ion import by regulation of transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter" BROAD [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0034756 ! regulation of iron ion transport is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0006366 ! transcription by RNA polymerase II intersection_of: regulates GO:0033212 ! iron import into cell relationship: regulates GO:0033212 ! iron import into cell creation_date: 2012-04-20T02:34:12Z [Term] id: GO:1900402 name: obsolete regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process." [GOC:mah, GOC:TermGenie, PMID:16408318] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-20T02:45:27Z [Term] id: GO:1900403 name: negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cellular amino acid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:17446861] synonym: "negative regulation of amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular amino acid anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular amino acid biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular amino acid formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular amino acid synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0072365 ! regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process created_by: mah creation_date: 2012-04-20T02:45:42Z [Term] id: GO:1900404 name: positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair." [GOC:mah, GOC:TermGenie, PMID:20299455] synonym: "activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045739 ! positive regulation of DNA repair is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0100026 ! positive regulation of DNA repair by transcription from RNA polymerase II promoter relationship: positively_regulates GO:0100026 ! positive regulation of DNA repair by transcription from RNA polymerase II promoter created_by: mah creation_date: 2012-04-20T02:45:56Z [Term] id: GO:1900405 name: obsolete regulation of cell separation after cytokinesis by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cell separation after cytokinesis." [GOC:mah, GOC:TermGenie, PMID:10491317, PMID:12665550] synonym: "regulation of cytokinetic cell separation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-20T02:46:10Z [Term] id: GO:1900406 name: regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion." [GOC:mah, GOC:TermGenie, PMID:1112904] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0031137 ! regulation of conjugation with cellular fusion intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: regulates GO:0000747 ! conjugation with cellular fusion created_by: mah creation_date: 2012-04-20T02:46:24Z [Term] id: GO:1900407 name: regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034599 ! cellular response to oxidative stress relationship: regulates GO:0034599 ! cellular response to oxidative stress created_by: mah creation_date: 2012-04-20T03:30:52Z [Term] id: GO:1900408 name: negative regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034599 ! cellular response to oxidative stress relationship: negatively_regulates GO:0034599 ! cellular response to oxidative stress created_by: mah creation_date: 2012-04-20T03:31:05Z [Term] id: GO:1900409 name: positive regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034599 ! cellular response to oxidative stress relationship: positively_regulates GO:0034599 ! cellular response to oxidative stress created_by: mah creation_date: 2012-04-20T03:31:16Z [Term] id: GO:1900410 name: obsolete regulation of histone modification by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone modification." [GOC:mah, GOC:TermGenie] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: mah creation_date: 2012-04-20T03:35:08Z [Term] id: GO:1900411 name: obsolete regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone acetylation." [GOC:mah, GOC:TermGenie, PMID:15218150] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: mah creation_date: 2012-04-20T03:35:22Z [Term] id: GO:1900412 name: obsolete regulation of histone methylation by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone methylation." [GOC:mah, GOC:TermGenie, PMID:15218150] comment: This term was obsoleted because it describes a process that does not exist. is_obsolete: true created_by: mah creation_date: 2012-04-20T03:35:36Z [Term] id: GO:1900413 name: positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of phospholipid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16537923] synonym: "positive regulation of phospholipid biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phospholipid synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0008654 ! phospholipid biosynthetic process created_by: mah creation_date: 2012-04-20T03:41:58Z [Term] id: GO:1900414 name: obsolete regulation of cytokinesis by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cytokinesis." [GOC:mah, GOC:TermGenie, PMID:15509866] is_obsolete: true created_by: mah creation_date: 2012-04-20T03:42:13Z [Term] id: GO:1900415 name: obsolete regulation of fungal-type cell wall biogenesis by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of fungal-type cell wall biogenesis." [GOC:mah, GOC:TermGenie, PMID:15509866] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-20T03:42:27Z [Term] id: GO:1900416 name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of 4,6-pyruvylated galactose residue biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:15173185] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: mah creation_date: 2012-04-20T03:42:41Z [Term] id: GO:1900417 name: obsolete negative regulation of transmembrane transport by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of transmembrane transport." [GOC:mah, GOC:TermGenie, PMID:20404084] comment: The term was obsoleted because it is better represented by a GO-CAM model. is_obsolete: true created_by: mah creation_date: 2012-04-20T03:42:55Z [Term] id: GO:1900418 name: positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process." [GOC:curators, GOC:TermGenie, PMID:17573544] synonym: "activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process created_by: krc creation_date: 2012-04-20T10:13:58Z [Term] id: GO:1900419 name: regulation of cellular alcohol catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044109 ! cellular alcohol catabolic process relationship: regulates GO:0044109 ! cellular alcohol catabolic process created_by: krc creation_date: 2012-04-20T10:21:18Z [Term] id: GO:1900420 name: negative regulation of cellular alcohol catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] synonym: "down regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of cellular alcohol catabolic process" NARROW [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900419 ! regulation of cellular alcohol catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044109 ! cellular alcohol catabolic process relationship: negatively_regulates GO:0044109 ! cellular alcohol catabolic process created_by: krc creation_date: 2012-04-20T10:21:28Z [Term] id: GO:1900421 name: positive regulation of cellular alcohol catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] synonym: "activation of cellular alcohol catabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900419 ! regulation of cellular alcohol catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044109 ! cellular alcohol catabolic process relationship: positively_regulates GO:0044109 ! cellular alcohol catabolic process created_by: krc creation_date: 2012-04-20T10:21:46Z [Term] id: GO:1900422 name: obsolete positive regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of cellular alcohol catabolic process." [GOC:curators, GOC:TermGenie, PMID:3305157, PMID:8221926] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-04-24T05:13:25Z [Term] id: GO:1900423 name: obsolete positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:TermGenie, PMID:8804308] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "stimulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: krc creation_date: 2012-04-24T05:50:51Z [Term] id: GO:1900424 name: regulation of defense response to bacterium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042742 ! defense response to bacterium relationship: regulates GO:0042742 ! defense response to bacterium created_by: dhl creation_date: 2012-04-24T10:12:43Z [Term] id: GO:1900425 name: negative regulation of defense response to bacterium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie] synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042742 ! defense response to bacterium relationship: negatively_regulates GO:0042742 ! defense response to bacterium created_by: dhl creation_date: 2012-04-24T10:12:54Z [Term] id: GO:1900426 name: positive regulation of defense response to bacterium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie] synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042742 ! defense response to bacterium relationship: positively_regulates GO:0042742 ! defense response to bacterium created_by: dhl creation_date: 2012-04-24T10:13:13Z [Term] id: GO:1900427 name: obsolete regulation of cellular response to oxidative stress by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie, PMID:10348908] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of adaptive response to oxidative stress by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_obsolete: true created_by: mah creation_date: 2012-04-25T09:11:41Z [Term] id: GO:1900428 name: regulation of filamentous growth of a population of unicellular organisms namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] is_a: GO:0010570 ! regulation of filamentous growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms relationship: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: di creation_date: 2012-04-25T05:53:33Z [Term] id: GO:1900429 name: negative regulation of filamentous growth of a population of unicellular organisms namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie] is_a: GO:0060258 ! negative regulation of filamentous growth is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms relationship: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: di creation_date: 2012-04-25T05:53:43Z [Term] id: GO:1900430 name: positive regulation of filamentous growth of a population of unicellular organisms namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] is_a: GO:0090033 ! positive regulation of filamentous growth is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms relationship: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms created_by: di creation_date: 2012-04-25T05:53:52Z [Term] id: GO:1900431 name: regulation of filamentous growth of a population of unicellular organisms in response to heat namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat relationship: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat created_by: di creation_date: 2012-04-25T05:54:05Z [Term] id: GO:1900432 name: negative regulation of filamentous growth of a population of unicellular organisms in response to heat namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat relationship: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat created_by: di creation_date: 2012-04-25T05:54:15Z [Term] id: GO:1900433 name: positive regulation of filamentous growth of a population of unicellular organisms in response to heat namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat relationship: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat created_by: di creation_date: 2012-04-25T05:54:23Z [Term] id: GO:1900434 name: regulation of filamentous growth of a population of unicellular organisms in response to starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080134 ! regulation of response to stress is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation relationship: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation created_by: di creation_date: 2012-04-25T05:54:46Z [Term] id: GO:1900435 name: negative regulation of filamentous growth of a population of unicellular organisms in response to starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie] is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation relationship: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation created_by: di creation_date: 2012-04-25T05:54:56Z [Term] id: GO:1900436 name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation created_by: di creation_date: 2012-04-25T05:55:05Z [Term] id: GO:1900437 name: regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus relationship: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus created_by: di creation_date: 2012-04-25T05:55:17Z [Term] id: GO:1900438 name: negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus relationship: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus created_by: di creation_date: 2012-04-25T05:55:26Z [Term] id: GO:1900439 name: positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus relationship: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus created_by: di creation_date: 2012-04-25T05:55:35Z [Term] id: GO:1900440 name: regulation of filamentous growth of a population of unicellular organisms in response to neutral pH namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH relationship: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH created_by: di creation_date: 2012-04-25T05:55:48Z [Term] id: GO:1900441 name: negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie] is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH is_a: GO:1900742 ! negative regulation of filamentous growth of a population of unicellular organisms in response to pH intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH relationship: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH created_by: di creation_date: 2012-04-25T05:55:57Z [Term] id: GO:1900442 name: positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH is_a: GO:1900743 ! positive regulation of filamentous growth of a population of unicellular organisms in response to pH intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH relationship: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH created_by: di creation_date: 2012-04-25T05:56:06Z [Term] id: GO:1900443 name: regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus relationship: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus created_by: di creation_date: 2012-04-25T05:56:18Z [Term] id: GO:1900444 name: negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus relationship: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus created_by: di creation_date: 2012-04-25T05:56:27Z [Term] id: GO:1900445 name: positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus relationship: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus created_by: di creation_date: 2012-04-25T05:56:35Z [Term] id: GO:1900446 name: obsolete negative regulation of tRNA transcription from RNA polymerase III promoter namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tRNA transcription from RNA polymerase III promoter." [GOC:sart, GOC:TermGenie] comment: The reason for obsoletion is that there is no specific regulator for negatively regulating tRNA transcription which is separable from general negative regulation of transcription from RNA polymerase III. synonym: "down regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "inhibition of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] synonym: "inhibition of tRNA transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: sart creation_date: 2012-04-26T05:28:34Z [Term] id: GO:1900447 name: regulation of cell morphogenesis involved in phenotypic switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:di, GOC:TermGenie] synonym: "negative regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] synonym: "positive regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "positive regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] synonym: "regulation of cell morphogenesis of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of cell morphogenesis of phenotypic switching" EXACT [GOC:TermGenie] synonym: "regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0022604 ! regulation of cell morphogenesis intersection_of: part_of GO:0036166 ! phenotypic switching relationship: part_of GO:0036166 ! phenotypic switching created_by: di creation_date: 2012-04-27T02:43:32Z [Term] id: GO:1900448 name: obsolete regulation of pyrimidine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:TermGenie] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: jh creation_date: 2012-04-27T02:57:38Z [Term] id: GO:1900449 name: regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007215 ! glutamate receptor signaling pathway relationship: regulates GO:0007215 ! glutamate receptor signaling pathway created_by: rl creation_date: 2012-04-27T03:45:43Z [Term] id: GO:1900450 name: negative regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway relationship: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway created_by: rl creation_date: 2012-04-27T03:45:53Z [Term] id: GO:1900451 name: positive regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007215 ! glutamate receptor signaling pathway relationship: positively_regulates GO:0007215 ! glutamate receptor signaling pathway created_by: rl creation_date: 2012-04-27T03:46:03Z [Term] id: GO:1900452 name: regulation of long-term synaptic depression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] synonym: "regulation of long term depression" BROAD [GOC:TermGenie] synonym: "regulation of long term synaptic depression" EXACT [] synonym: "regulation of LTD" RELATED [GOC:TermGenie] is_a: GO:0048167 ! regulation of synaptic plasticity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060292 ! long-term synaptic depression relationship: regulates GO:0060292 ! long-term synaptic depression created_by: rl creation_date: 2012-04-27T03:54:58Z [Term] id: GO:1900453 name: negative regulation of long-term synaptic depression namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of long term depression" BROAD [GOC:TermGenie] synonym: "down regulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "down regulation of LTD" RELATED [GOC:TermGenie] synonym: "down-regulation of long term depression" BROAD [GOC:TermGenie] synonym: "down-regulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "down-regulation of LTD" RELATED [GOC:TermGenie] synonym: "downregulation of long term depression" BROAD [GOC:TermGenie] synonym: "downregulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "downregulation of LTD" RELATED [GOC:TermGenie] synonym: "inhibition of long term depression" BROAD [GOC:TermGenie] synonym: "inhibition of long term synaptic depression" NARROW [GOC:TermGenie] synonym: "inhibition of LTD" RELATED [GOC:TermGenie] synonym: "negative regulation of long term depression" BROAD [GOC:TermGenie] synonym: "negative regulation of long term synaptic depression" RELATED [] synonym: "negative regulation of LTD" RELATED [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:1900452 ! regulation of long-term synaptic depression intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060292 ! long-term synaptic depression relationship: negatively_regulates GO:0060292 ! long-term synaptic depression created_by: rl creation_date: 2012-04-27T03:55:14Z [Term] id: GO:1900454 name: positive regulation of long-term synaptic depression namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] synonym: "activation of long term depression" BROAD [GOC:TermGenie] synonym: "activation of long term synaptic depression" NARROW [GOC:TermGenie] synonym: "activation of LTD" RELATED [GOC:TermGenie] synonym: "positive regulation of long term depression" BROAD [GOC:TermGenie] synonym: "positive regulation of long term synaptic depression" EXACT [] synonym: "positive regulation of LTD" RELATED [GOC:TermGenie] synonym: "up regulation of long term depression" BROAD [GOC:TermGenie] synonym: "up regulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "up regulation of LTD" RELATED [GOC:TermGenie] synonym: "up-regulation of long term depression" BROAD [GOC:TermGenie] synonym: "up-regulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "up-regulation of LTD" RELATED [GOC:TermGenie] synonym: "upregulation of long term depression" BROAD [GOC:TermGenie] synonym: "upregulation of long term synaptic depression" EXACT [GOC:TermGenie] synonym: "upregulation of LTD" RELATED [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1900452 ! regulation of long-term synaptic depression intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060292 ! long-term synaptic depression relationship: positively_regulates GO:0060292 ! long-term synaptic depression created_by: rl creation_date: 2012-04-27T03:55:23Z [Term] id: GO:1900455 name: regulation of flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252] is_a: GO:0060256 ! regulation of flocculation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction created_by: dianna.fisk creation_date: 2012-05-01T05:03:32Z [Term] id: GO:1900456 name: obsolete regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10373537, PMID:10591965, PMID:12024013, PMID:15466424, PMID:16568252, PMID:8710886, PMID:9811878, PMID:9987114] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of colony morphology by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter" EXACT [] is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T05:42:03Z [Term] id: GO:1900457 name: regulation of brassinosteroid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] synonym: "regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009742 ! brassinosteroid mediated signaling pathway relationship: regulates GO:0009742 ! brassinosteroid mediated signaling pathway created_by: dhl creation_date: 2012-05-01T06:12:04Z [Term] id: GO:1900458 name: negative regulation of brassinosteroid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] synonym: "down regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "down-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "downregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "inhibition of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway relationship: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway created_by: dhl creation_date: 2012-05-01T06:12:13Z [Term] id: GO:1900459 name: positive regulation of brassinosteroid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] synonym: "activation of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "positive regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "up regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "up-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] synonym: "upregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway relationship: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway created_by: dhl creation_date: 2012-05-01T06:12:23Z [Term] id: GO:1900460 name: obsolete negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024013, PMID:15466424, PMID:9811878] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "negative regulation of colony morphology by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T06:09:17Z [Term] id: GO:1900461 name: positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:2000222 ! positive regulation of pseudohyphal growth intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0007124 ! pseudohyphal growth created_by: dianna.fisk creation_date: 2012-05-01T07:01:40Z [Term] id: GO:1900462 name: negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024012, PMID:9811878] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:2000221 ! negative regulation of pseudohyphal growth intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0007124 ! pseudohyphal growth created_by: dianna.fisk creation_date: 2012-05-01T07:01:54Z [Term] id: GO:1900463 name: negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] synonym: "negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter" BROAD [] synonym: "negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1900068 ! negative regulation of cellular response to alkaline pH intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0071469 ! cellular response to alkaline pH created_by: dianna.fisk creation_date: 2012-05-01T07:22:50Z [Term] id: GO:1900464 name: negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:16278455] synonym: "negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1900070 ! negative regulation of cellular hyperosmotic salinity response intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response created_by: dianna.fisk creation_date: 2012-05-01T07:29:19Z [Term] id: GO:1900465 name: negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular arginine catabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631] synonym: "negative regulation of arginine breakdown by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of arginine catabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of arginine degradation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0033243 ! positive regulation of cellular amine catabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0072365 ! regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter is_a: GO:1900081 ! regulation of arginine catabolic process intersection_of: GO:0050789 ! regulation of biological process intersection_of: negatively_regulates GO:0100045 ! negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter relationship: negatively_regulates GO:0100045 ! negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter created_by: dianna.fisk creation_date: 2012-05-01T07:38:01Z [Term] id: GO:1900466 name: positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631] synonym: "activation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0072366 ! regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter is_a: GO:1900080 ! positive regulation of arginine biosynthetic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006526 ! arginine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T07:38:14Z [Term] id: GO:1900467 name: obsolete regulation of cellular potassium ion homeostasis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular potassium ion homeostasis." [GOC:dgf, GOC:TermGenie, PMID:20412803] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of cellular potassium ion homeostasis" EXACT [] is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T07:48:07Z [Term] id: GO:1900468 name: regulation of phosphatidylserine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] synonym: "regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006659 ! phosphatidylserine biosynthetic process relationship: regulates GO:0006659 ! phosphatidylserine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T08:01:01Z [Term] id: GO:1900469 name: negative regulation of phosphatidylserine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] synonym: "down regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process relationship: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T08:01:11Z [Term] id: GO:1900470 name: positive regulation of phosphatidylserine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] synonym: "activation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine formation" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T08:01:19Z [Term] id: GO:1900471 name: obsolete negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of inositol biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "negative regulation of inositol anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of inositol synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of myo-inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of myo-inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of vitamin Bh biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of vitamin Bh biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T08:13:23Z [Term] id: GO:1900472 name: positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] synonym: "positive regulation of phosphatidylcholine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylcholine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylcholine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylcholine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:1900413 ! positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter is_a: GO:2001247 ! positive regulation of phosphatidylcholine biosynthetic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T08:13:36Z [Term] id: GO:1900473 name: negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324] synonym: "negative regulation of phosphatidylcholine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylcholine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylcholine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylcholine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:2001246 ! negative regulation of phosphatidylcholine biosynthetic process intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process created_by: dianna.fisk creation_date: 2012-05-01T08:13:51Z [Term] id: GO:1900474 name: obsolete negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8625408, PMID:8625409] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T08:33:18Z [Term] id: GO:1900477 name: negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19841732] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle created_by: dianna.fisk creation_date: 2012-05-01T09:01:04Z [Term] id: GO:1900478 name: obsolete positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sulfate assimilation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:7601277, PMID:7891681] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_obsolete: true created_by: dianna.fisk creation_date: 2012-05-01T09:08:04Z [Term] id: GO:1900479 name: positive regulation of flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252] synonym: "activation of flocculation via cell wall protein-carbohydrate interaction" NARROW [GOC:TermGenie] synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] is_a: GO:1900455 ! regulation of flocculation via cell wall protein-carbohydrate interaction is_a: GO:1900735 ! positive regulation of flocculation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction created_by: dgf creation_date: 2012-05-01T10:28:57Z [Term] id: GO:1900480 name: regulation of diacylglycerol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] synonym: "regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006651 ! diacylglycerol biosynthetic process relationship: regulates GO:0006651 ! diacylglycerol biosynthetic process created_by: al creation_date: 2012-05-02T10:08:59Z [Term] id: GO:1900481 name: negative regulation of diacylglycerol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] synonym: "down regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "inhibition of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process relationship: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process created_by: al creation_date: 2012-05-02T10:09:09Z [Term] id: GO:1900482 name: positive regulation of diacylglycerol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] synonym: "activation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "activation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "activation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol formation" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process relationship: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process created_by: al creation_date: 2012-05-02T10:09:18Z [Term] id: GO:1900483 name: regulation of protein targeting to vacuolar membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] is_a: GO:0090313 ! regulation of protein targeting to membrane is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044395 ! protein targeting to vacuolar membrane relationship: regulates GO:0044395 ! protein targeting to vacuolar membrane created_by: al creation_date: 2012-05-02T10:13:23Z [Term] id: GO:1900484 name: negative regulation of protein targeting to vacuolar membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] synonym: "down regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie] is_a: GO:0090315 ! negative regulation of protein targeting to membrane is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane is_a: GO:1903336 ! negative regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane relationship: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane created_by: al creation_date: 2012-05-02T10:13:33Z [Term] id: GO:1900485 name: positive regulation of protein targeting to vacuolar membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] synonym: "activation of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie] synonym: "up regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0090314 ! positive regulation of protein targeting to membrane is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane is_a: GO:1903337 ! positive regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane relationship: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane created_by: al creation_date: 2012-05-02T10:13:41Z [Term] id: GO:1900486 name: positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:TermGenie] synonym: "activation of Ac-MVA pathway" EXACT [GOC:TermGenie] synonym: "activation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] synonym: "activation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" NARROW [GOC:TermGenie] synonym: "activation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "activation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] synonym: "up regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Ac-MVA pathway" EXACT [GOC:TermGenie] synonym: "upregulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] synonym: "upregulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "upregulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway relationship: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway created_by: al creation_date: 2012-05-02T10:46:46Z [Term] id: GO:1900487 name: regulation of [2Fe-2S] cluster assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] synonym: "regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044571 ! [2Fe-2S] cluster assembly relationship: regulates GO:0044571 ! [2Fe-2S] cluster assembly created_by: tt creation_date: 2012-05-02T01:22:22Z [Term] id: GO:1900488 name: negative regulation of [2Fe-2S] cluster assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "down regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "down regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie] synonym: "inhibition of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie] synonym: "inhibition of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly relationship: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly created_by: tt creation_date: 2012-05-02T01:22:32Z [Term] id: GO:1900489 name: positive regulation of [2Fe-2S] cluster assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] synonym: "activation of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie] synonym: "activation of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie] synonym: "activation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly relationship: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly created_by: tt creation_date: 2012-05-02T01:22:40Z [Term] id: GO:1900490 name: positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:TermGenie] synonym: "activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] synonym: "activation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] synonym: "activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] synonym: "positive regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] synonym: "up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] synonym: "up regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] synonym: "up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] synonym: "up-regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] synonym: "up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] synonym: "upregulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] synonym: "upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:2001215 ! regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity relationship: positively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity created_by: al creation_date: 2012-05-02T03:01:43Z [Term] id: GO:1900491 name: regulation of [4Fe-4S] cluster assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] synonym: "regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044572 ! [4Fe-4S] cluster assembly relationship: regulates GO:0044572 ! [4Fe-4S] cluster assembly created_by: tt creation_date: 2012-05-02T03:48:49Z [Term] id: GO:1900492 name: negative regulation of [4Fe-4S] cluster assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] synonym: "down regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "down regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "down regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie] synonym: "inhibition of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie] synonym: "inhibition of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly relationship: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly created_by: tt creation_date: 2012-05-02T03:49:00Z [Term] id: GO:1900493 name: positive regulation of [4Fe-4S] cluster assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] synonym: "activation of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie] synonym: "activation of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie] synonym: "activation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly relationship: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly created_by: tt creation_date: 2012-05-02T03:49:10Z [Term] id: GO:1900494 name: regulation of butyryl-CoA biosynthetic process from acetyl-CoA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA relationship: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA created_by: tt creation_date: 2012-05-02T03:51:38Z [Term] id: GO:1900495 name: negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "down regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie] synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA relationship: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA created_by: tt creation_date: 2012-05-02T03:51:49Z [Term] id: GO:1900496 name: positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "activation of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie] synonym: "positive regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA relationship: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA created_by: tt creation_date: 2012-05-02T03:51:58Z [Term] id: GO:1900497 name: regulation of butyryl-CoA catabolic process to butanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol relationship: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol created_by: tt creation_date: 2012-05-02T03:53:20Z [Term] id: GO:1900498 name: negative regulation of butyryl-CoA catabolic process to butanol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "down regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "inhibition of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie] synonym: "inhibition of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "negative regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol relationship: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol created_by: tt creation_date: 2012-05-02T03:53:31Z [Term] id: GO:1900499 name: positive regulation of butyryl-CoA catabolic process to butanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie] synonym: "activation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "positive regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol relationship: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol created_by: tt creation_date: 2012-05-02T03:53:40Z [Term] id: GO:1900500 name: regulation of butyryl-CoA catabolic process to butyrate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate created_by: tt creation_date: 2012-05-02T03:56:19Z [Term] id: GO:1900501 name: negative regulation of butyryl-CoA catabolic process to butyrate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "down regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "down-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "downregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "inhibition of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie] synonym: "inhibition of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "negative regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate relationship: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate created_by: tt creation_date: 2012-05-02T03:56:30Z [Term] id: GO:1900502 name: positive regulation of butyryl-CoA catabolic process to butyrate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie] synonym: "activation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "positive regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "up regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "up-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] synonym: "upregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate relationship: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate created_by: tt creation_date: 2012-05-02T03:56:40Z [Term] id: GO:1900503 name: regulation of cellulosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044575 ! cellulosome assembly relationship: regulates GO:0044575 ! cellulosome assembly created_by: tt creation_date: 2012-05-02T03:58:15Z [Term] id: GO:1900504 name: negative regulation of cellulosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of cellulosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cellulosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cellulosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cellulosome assembly" NARROW [GOC:TermGenie] is_a: GO:1900503 ! regulation of cellulosome assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044575 ! cellulosome assembly relationship: negatively_regulates GO:0044575 ! cellulosome assembly created_by: tt creation_date: 2012-05-02T03:58:26Z [Term] id: GO:1900505 name: positive regulation of cellulosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of cellulosome assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cellulosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cellulosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cellulosome assembly" EXACT [GOC:TermGenie] is_a: GO:1900503 ! regulation of cellulosome assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044575 ! cellulosome assembly relationship: positively_regulates GO:0044575 ! cellulosome assembly created_by: tt creation_date: 2012-05-02T03:58:35Z [Term] id: GO:1900506 name: regulation of iron-sulfur-molybdenum cofactor assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly created_by: tt creation_date: 2012-05-02T04:02:16Z [Term] id: GO:1900507 name: negative regulation of iron-sulfur-molybdenum cofactor assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "down regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "down regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "downregulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "downregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "downregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "inhibition of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "inhibition of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "inhibition of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly created_by: tt creation_date: 2012-05-02T04:02:27Z [Term] id: GO:1900508 name: positive regulation of iron-sulfur-molybdenum cofactor assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "activation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "activation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "activation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "activation of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "up regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "up regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "upregulation of FeMoco assembly" EXACT [GOC:TermGenie] synonym: "upregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly created_by: tt creation_date: 2012-05-02T04:02:37Z [Term] id: GO:1900509 name: regulation of pentose catabolic process to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044576 ! pentose catabolic process to ethanol relationship: regulates GO:0044576 ! pentose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:04:40Z [Term] id: GO:1900510 name: negative regulation of pentose catabolic process to ethanol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "down regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "down-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "down-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "downregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "downregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "inhibition of pentose catabolic process to ethanol" NARROW [GOC:TermGenie] synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044576 ! pentose catabolic process to ethanol relationship: negatively_regulates GO:0044576 ! pentose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:04:51Z [Term] id: GO:1900511 name: positive regulation of pentose catabolic process to ethanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of pentose catabolic process to ethanol" NARROW [GOC:TermGenie] synonym: "activation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "positive regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "up regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "up regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "up-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "up-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044576 ! pentose catabolic process to ethanol relationship: positively_regulates GO:0044576 ! pentose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:05:01Z [Term] id: GO:1900512 name: regulation of starch utilization system complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "regulation of SUS complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044574 ! starch utilization system complex assembly relationship: regulates GO:0044574 ! starch utilization system complex assembly created_by: tt creation_date: 2012-05-02T04:06:44Z [Term] id: GO:1900513 name: negative regulation of starch utilization system complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "down regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "down-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "downregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "inhibition of starch utilization system complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "negative regulation of SUS complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1900512 ! regulation of starch utilization system complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044574 ! starch utilization system complex assembly relationship: negatively_regulates GO:0044574 ! starch utilization system complex assembly created_by: tt creation_date: 2012-05-02T04:06:54Z [Term] id: GO:1900514 name: positive regulation of starch utilization system complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "activation of starch utilization system complex assembly" NARROW [GOC:TermGenie] synonym: "activation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "positive regulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "up regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "up-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of SUS complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] synonym: "upregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of SUS complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1900512 ! regulation of starch utilization system complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044574 ! starch utilization system complex assembly relationship: positively_regulates GO:0044574 ! starch utilization system complex assembly created_by: tt creation_date: 2012-05-02T04:07:04Z [Term] id: GO:1900515 name: regulation of xylose catabolic process to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0043469 ! regulation of D-xylose catabolic process is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044577 ! xylose catabolic process to ethanol relationship: regulates GO:0044577 ! xylose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:09:07Z [Term] id: GO:1900516 name: negative regulation of xylose catabolic process to ethanol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "down regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "down-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "down-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "downregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "downregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "inhibition of xylose catabolic process to ethanol" NARROW [GOC:TermGenie] synonym: "inhibition of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "negative regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:1900510 ! negative regulation of pentose catabolic process to ethanol is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044577 ! xylose catabolic process to ethanol relationship: negatively_regulates GO:0044577 ! xylose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:09:17Z [Term] id: GO:1900517 name: positive regulation of xylose catabolic process to ethanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of xylose catabolic process to ethanol" NARROW [GOC:TermGenie] synonym: "activation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "positive regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "up regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "up regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "up-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "up-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:1900511 ! positive regulation of pentose catabolic process to ethanol is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044577 ! xylose catabolic process to ethanol relationship: positively_regulates GO:0044577 ! xylose catabolic process to ethanol created_by: tt creation_date: 2012-05-02T04:09:26Z [Term] id: GO:1900518 name: regulation of response to pullulan namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044592 ! response to pullulan relationship: regulates GO:0044592 ! response to pullulan created_by: tt creation_date: 2012-05-02T04:11:58Z [Term] id: GO:1900519 name: negative regulation of response to pullulan namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to pullulan" EXACT [GOC:TermGenie] synonym: "down-regulation of response to pullulan" EXACT [GOC:TermGenie] synonym: "downregulation of response to pullulan" EXACT [GOC:TermGenie] synonym: "inhibition of response to pullulan" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900518 ! regulation of response to pullulan intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044592 ! response to pullulan relationship: negatively_regulates GO:0044592 ! response to pullulan created_by: tt creation_date: 2012-05-02T04:12:09Z [Term] id: GO:1900520 name: positive regulation of response to pullulan namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to pullulan" NARROW [GOC:TermGenie] synonym: "up regulation of response to pullulan" EXACT [GOC:TermGenie] synonym: "up-regulation of response to pullulan" EXACT [GOC:TermGenie] synonym: "upregulation of response to pullulan" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900518 ! regulation of response to pullulan intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044592 ! response to pullulan relationship: positively_regulates GO:0044592 ! response to pullulan created_by: tt creation_date: 2012-05-02T04:12:19Z [Term] id: GO:1900521 name: regulation of response to amylopectin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044591 ! response to amylopectin relationship: regulates GO:0044591 ! response to amylopectin created_by: tt creation_date: 2012-05-02T04:13:51Z [Term] id: GO:1900522 name: negative regulation of response to amylopectin namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to amylopectin" EXACT [GOC:TermGenie] synonym: "down-regulation of response to amylopectin" EXACT [GOC:TermGenie] synonym: "downregulation of response to amylopectin" EXACT [GOC:TermGenie] synonym: "inhibition of response to amylopectin" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900521 ! regulation of response to amylopectin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044591 ! response to amylopectin relationship: negatively_regulates GO:0044591 ! response to amylopectin created_by: tt creation_date: 2012-05-02T04:14:01Z [Term] id: GO:1900523 name: positive regulation of response to amylopectin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to amylopectin" NARROW [GOC:TermGenie] synonym: "up regulation of response to amylopectin" EXACT [GOC:TermGenie] synonym: "up-regulation of response to amylopectin" EXACT [GOC:TermGenie] synonym: "upregulation of response to amylopectin" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900521 ! regulation of response to amylopectin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044591 ! response to amylopectin relationship: positively_regulates GO:0044591 ! response to amylopectin created_by: tt creation_date: 2012-05-02T04:14:11Z [Term] id: GO:1900524 name: positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252] synonym: "activation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1900479 ! positive regulation of flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction created_by: dgf creation_date: 2012-05-03T05:13:41Z [Term] id: GO:1900525 name: positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] synonym: "activation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "activation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:1900413 ! positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter is_a: GO:1900470 ! positive regulation of phosphatidylserine biosynthetic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process created_by: dgf creation_date: 2012-05-03T05:13:55Z [Term] id: GO:1900526 name: negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324] synonym: "negative regulation of phosphatidylserine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1900470 ! positive regulation of phosphatidylserine biosynthetic process intersection_of: GO:0050789 ! regulation of biological process intersection_of: negatively_regulates GO:0100056 ! negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter relationship: negatively_regulates GO:0100056 ! negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter created_by: dgf creation_date: 2012-05-03T05:14:10Z [Term] id: GO:1900527 name: obsolete regulation of nucleus size involved in G1 to G0 transition namespace: biological_process def: "OBSOLETE. Any regulation of nucleus size that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728] comment: This term was made obsolete because it represents a phenotype. synonym: "regulation of nuclear size involved in cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "regulation of nuclear size involved in establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "regulation of nuclear size involved in G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of nuclear size involved in G1/G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of nuclear size involved in stationary phase" RELATED [GOC:TermGenie] synonym: "regulation of nuclear volume involved in cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "regulation of nuclear volume involved in establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "regulation of nuclear volume involved in G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of nuclear volume involved in G1/G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of nuclear volume involved in stationary phase" RELATED [GOC:TermGenie] synonym: "regulation of nucleus size involved in cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "regulation of nucleus size involved in establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "regulation of nucleus size involved in G1 to G0 transition" EXACT [] synonym: "regulation of nucleus size involved in G1/G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of nucleus size involved in stationary phase" RELATED [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-05-08T10:39:01Z [Term] id: GO:1900528 name: obsolete regulation of cell shape involved in G1 to G0 transition namespace: biological_process def: "OBSOLETE. Any regulation of cell shape that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728] comment: This term was made obsolete because it represents a phenotype. synonym: "regulation of cell shape involved in cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "regulation of cell shape involved in establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "regulation of cell shape involved in G1 to G0 transition" EXACT [] synonym: "regulation of cell shape involved in G1/G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of cell shape involved in stationary phase" RELATED [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-05-08T10:42:45Z [Term] id: GO:1900529 name: obsolete regulation of cell shape involved in cellular response to glucose starvation namespace: biological_process def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to glucose starvation." [GOC:al, GOC:TermGenie, PMID:9135147] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of cell shape involved in cellular response to glucose starvation" EXACT [] is_obsolete: true created_by: al creation_date: 2012-05-08T01:43:38Z [Term] id: GO:1900530 name: obsolete regulation of cell shape involved in cellular response to salt stress namespace: biological_process def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to salt stress." [GOC:al, GOC:TermGenie, PMID:9135147] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of cell shape involved in cellular response to salt stress" EXACT [] synonym: "regulation of cell shape of cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "regulation of cell shape of cellular response to salt stress" EXACT [GOC:TermGenie] synonym: "regulation of cell shape of cellular salinity response" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-05-08T01:48:01Z [Term] id: GO:1900531 name: obsolete regulation of cell shape involved in cellular response to heat namespace: biological_process def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to heat." [GOC:al, GOC:TermGenie, PMID:9135147] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of cell shape involved in cellular response to heat" EXACT [] synonym: "regulation of cell shape of cellular response to heat" EXACT [GOC:TermGenie] synonym: "regulation of cell shape of cellular response to heat stress" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-05-08T01:51:00Z [Term] id: GO:1900532 name: obsolete negative regulation of cell proliferation involved in cellular hyperosmotic response namespace: biological_process def: "OBSOLETE. negative regulation of cell proliferation during cellular hyperosmotic response" [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] synonym: "inhibition of cell proliferation of cellular HOG response" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation of cellular hyperosmotic response" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation of cellular hypertonic response" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation of cellular response to hypertonicity" NARROW [GOC:TermGenie] synonym: "negative regulation of cell proliferation involved in cellular hyperosmotic response" EXACT [] synonym: "negative regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] synonym: "negative regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] synonym: "negative regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] synonym: "negative regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-05-08T02:42:52Z [Term] id: GO:1900533 name: palmitic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie] is_a: GO:0001676 ! long-chain fatty acid metabolic process created_by: tb creation_date: 2012-05-09T07:03:55Z [Term] id: GO:1900534 name: palmitic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of palmitic acid." [GOC:TermGenie] is_a: GO:0042758 ! long-chain fatty acid catabolic process is_a: GO:1900533 ! palmitic acid metabolic process created_by: tb creation_date: 2012-05-09T07:04:56Z [Term] id: GO:1900535 name: palmitic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie] is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1900533 ! palmitic acid metabolic process created_by: tb creation_date: 2012-05-09T07:05:17Z [Term] id: GO:1900536 name: obsolete regulation of glucose homeostasis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of glucose homeostasis" EXACT [] is_obsolete: true created_by: hjd creation_date: 2012-05-10T06:52:21Z [Term] id: GO:1900537 name: obsolete negative regulation of glucose homeostasis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of glucose homeostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose homeostasis" EXACT [GOC:TermGenie] synonym: "downregulation of glucose homeostasis" EXACT [GOC:TermGenie] synonym: "inhibition of glucose homeostasis" NARROW [GOC:TermGenie] synonym: "negative regulation of glucose homeostasis" EXACT [] is_obsolete: true created_by: hjd creation_date: 2012-05-10T06:53:14Z [Term] id: GO:1900538 name: obsolete positive regulation of glucose homeostasis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of glucose homeostasis" NARROW [GOC:TermGenie] synonym: "positive regulation of glucose homeostasis" EXACT [] synonym: "up regulation of glucose homeostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose homeostasis" EXACT [GOC:TermGenie] synonym: "upregulation of glucose homeostasis" EXACT [GOC:TermGenie] is_obsolete: true created_by: hjd creation_date: 2012-05-10T06:53:38Z [Term] id: GO:1900539 name: fumonisin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie] synonym: "fumonisin metabolism" RELATED [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0043385 ! mycotoxin metabolic process created_by: tb creation_date: 2012-05-11T12:53:29Z [Term] id: GO:1900540 name: fumonisin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumonisin." [GOC:TermGenie] synonym: "fumonisin breakdown" EXACT [] synonym: "fumonisin catabolism" EXACT [] synonym: "fumonisin degradation" RELATED [] is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900539 ! fumonisin metabolic process created_by: tb creation_date: 2012-05-11T12:54:12Z [Term] id: GO:1900541 name: fumonisin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumonisin." [GOC:TermGenie] synonym: "fumonisin anabolism" EXACT [] synonym: "fumonisin biosynthesis" EXACT [] synonym: "fumonisin formation" EXACT [] synonym: "fumonisin synthesis" EXACT [] is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900539 ! fumonisin metabolic process created_by: tb creation_date: 2012-05-11T12:54:37Z [Term] id: GO:1900542 name: regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006140 ! regulation of nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006163 ! purine nucleotide metabolic process relationship: regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:43:15Z [Term] id: GO:1900543 name: negative regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045980 ! negative regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006163 ! purine nucleotide metabolic process relationship: negatively_regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:44:21Z [Term] id: GO:1900544 name: positive regulation of purine nucleotide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine metabolism" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie] synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0045981 ! positive regulation of nucleotide metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006163 ! purine nucleotide metabolic process relationship: positively_regulates GO:0006163 ! purine nucleotide metabolic process created_by: krc creation_date: 2012-05-11T05:44:43Z [Term] id: GO:1900545 name: regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching." [GOC:di, GOC:TermGenie] synonym: "regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: regulates GO:0036166 ! phenotypic switching created_by: di creation_date: 2012-05-14T11:28:41Z [Term] id: GO:1900546 name: obsolete positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of phenotypic switching." [GOC:di, GOC:TermGenie] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "activation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up-regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "upregulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: di creation_date: 2012-05-14T11:36:05Z [Term] id: GO:1900547 name: obsolete negative regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of phenotypic switching." [GOC:di, GOC:TermGenie] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "negative regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] is_obsolete: true created_by: di creation_date: 2012-05-14T11:40:54Z [Term] id: GO:1900548 name: heme b catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5874, UniPathway:UPA00684] synonym: "heme b breakdown" EXACT [GOC:TermGenie] synonym: "heme b catabolism" EXACT [GOC:TermGenie] synonym: "heme b degradation" EXACT [GOC:TermGenie] synonym: "protoheme catabolic process" EXACT [] synonym: "protoheme degradation" EXACT [] is_a: GO:0042167 ! heme catabolic process is_a: GO:0046492 ! heme b metabolic process created_by: pr creation_date: 2012-05-14T12:35:18Z [Term] id: GO:1900549 name: N',N'',N'''-triacetylfusarinine C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C metabolism" EXACT [GOC:TermGenie] is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: di creation_date: 2012-05-15T12:59:06Z [Term] id: GO:1900550 name: N',N'',N'''-triacetylfusarinine C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C breakdown" EXACT [GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C catabolism" EXACT [GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C degradation" EXACT [GOC:TermGenie] is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: di creation_date: 2012-05-15T01:00:07Z [Term] id: GO:1900551 name: N',N'',N'''-triacetylfusarinine C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: di creation_date: 2012-05-15T01:00:58Z [Term] id: GO:1900552 name: asperfuranone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie] synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: di creation_date: 2012-05-15T01:30:48Z [Term] id: GO:1900553 name: asperfuranone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asperfuranone." [GOC:di, GOC:TermGenie] synonym: "asperfuranone breakdown" EXACT [GOC:TermGenie] synonym: "asperfuranone catabolism" EXACT [GOC:TermGenie] synonym: "asperfuranone degradation" EXACT [GOC:TermGenie] is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900552 ! asperfuranone metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T01:31:35Z [Term] id: GO:1900554 name: asperfuranone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asperfuranone." [GOC:di, GOC:TermGenie] synonym: "asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "asperfuranone formation" EXACT [GOC:TermGenie] synonym: "asperfuranone synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1900552 ! asperfuranone metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: di creation_date: 2012-05-15T01:31:58Z [Term] id: GO:1900555 name: emericellamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving emericellamide." [GOC:di, GOC:TermGenie] synonym: "emericellamide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0050761 ! depsipeptide metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: di creation_date: 2012-05-15T01:32:19Z [Term] id: GO:1900556 name: emericellamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of emericellamide." [GOC:di, GOC:TermGenie] synonym: "emericellamide breakdown" EXACT [GOC:TermGenie] synonym: "emericellamide catabolism" EXACT [GOC:TermGenie] synonym: "emericellamide degradation" EXACT [GOC:TermGenie] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0050762 ! depsipeptide catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900555 ! emericellamide metabolic process is_a: GO:1901335 ! lactone catabolic process created_by: di creation_date: 2012-05-15T01:33:07Z [Term] id: GO:1900557 name: emericellamide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of emericellamide." [GOC:di, GOC:TermGenie] synonym: "emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "emericellamide formation" EXACT [GOC:TermGenie] synonym: "emericellamide synthesis" EXACT [GOC:TermGenie] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0050763 ! depsipeptide biosynthetic process is_a: GO:1900555 ! emericellamide metabolic process is_a: GO:1901336 ! lactone biosynthetic process created_by: di creation_date: 2012-05-15T01:33:31Z [Term] id: GO:1900558 name: austinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving austinol." [GOC:di, GOC:TermGenie] synonym: "austinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: di creation_date: 2012-05-15T06:26:58Z [Term] id: GO:1900559 name: austinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of austinol." [GOC:di, GOC:TermGenie] synonym: "austinol breakdown" EXACT [GOC:TermGenie] synonym: "austinol catabolism" EXACT [GOC:TermGenie] synonym: "austinol degradation" EXACT [GOC:TermGenie] is_a: GO:1900558 ! austinol metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: di creation_date: 2012-05-15T06:27:22Z [Term] id: GO:1900560 name: austinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of austinol." [GOC:di, GOC:TermGenie] synonym: "austinol anabolism" EXACT [GOC:TermGenie] synonym: "austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "austinol formation" EXACT [GOC:TermGenie] synonym: "austinol synthesis" EXACT [GOC:TermGenie] is_a: GO:1900558 ! austinol metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: di creation_date: 2012-05-15T06:27:30Z [Term] id: GO:1900561 name: dehydroaustinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dehydroaustinol." [GOC:di, GOC:TermGenie] synonym: "dehydroaustinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: di creation_date: 2012-05-15T06:27:35Z [Term] id: GO:1900562 name: dehydroaustinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dehydroaustinol." [GOC:di, GOC:TermGenie] synonym: "dehydroaustinol breakdown" EXACT [GOC:TermGenie] synonym: "dehydroaustinol catabolism" EXACT [GOC:TermGenie] synonym: "dehydroaustinol degradation" EXACT [GOC:TermGenie] is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900561 ! dehydroaustinol metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: di creation_date: 2012-05-15T06:27:55Z [Term] id: GO:1900563 name: dehydroaustinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dehydroaustinol." [GOC:di, GOC:TermGenie] synonym: "dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "dehydroaustinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900561 ! dehydroaustinol metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: di creation_date: 2012-05-15T06:28:03Z [Term] id: GO:1900564 name: chanoclavine-I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chanoclavine-I." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I metabolism" EXACT [GOC:TermGenie] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0035836 ! ergot alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-05-15T06:30:25Z [Term] id: GO:1900565 name: chanoclavine-I catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I breakdown" EXACT [GOC:TermGenie] synonym: "chanoclavine-I catabolism" EXACT [GOC:TermGenie] synonym: "chanoclavine-I degradation" EXACT [GOC:TermGenie] is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900564 ! chanoclavine-I metabolic process is_a: GO:1900806 ! ergot alkaloid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T06:30:48Z [Term] id: GO:1900566 name: chanoclavine-I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "chanoclavine-I synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0035837 ! ergot alkaloid biosynthetic process is_a: GO:1900564 ! chanoclavine-I metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T06:30:55Z [Term] id: GO:1900567 name: chanoclavine-I aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I aldehyde metabolism" EXACT [GOC:TermGenie] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0035836 ! ergot alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-05-15T06:31:00Z [Term] id: GO:1900568 name: chanoclavine-I aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I aldehyde breakdown" EXACT [GOC:TermGenie] synonym: "chanoclavine-I aldehyde catabolism" EXACT [GOC:TermGenie] synonym: "chanoclavine-I aldehyde degradation" EXACT [GOC:TermGenie] is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process is_a: GO:1900806 ! ergot alkaloid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T06:31:21Z [Term] id: GO:1900569 name: chanoclavine-I aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] synonym: "chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] is_a: GO:0035837 ! ergot alkaloid biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T06:31:28Z [Term] id: GO:1900570 name: diorcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diorcinol." [GOC:di, GOC:TermGenie] synonym: "diorcinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process created_by: di creation_date: 2012-05-15T06:35:01Z [Term] id: GO:1900571 name: diorcinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diorcinol." [GOC:di, GOC:TermGenie] synonym: "diorcinol breakdown" EXACT [GOC:TermGenie] synonym: "diorcinol catabolism" EXACT [GOC:TermGenie] synonym: "diorcinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900570 ! diorcinol metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-05-15T06:35:22Z [Term] id: GO:1900572 name: diorcinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diorcinol." [GOC:di, GOC:TermGenie] synonym: "diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "diorcinol formation" EXACT [GOC:TermGenie] synonym: "diorcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900570 ! diorcinol metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-05-15T06:35:29Z [Term] id: GO:1900573 name: emodin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie] synonym: "emodin metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: di creation_date: 2012-05-15T06:41:44Z [Term] id: GO:1900574 name: emodin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of emodin." [GOC:di, GOC:TermGenie] synonym: "emodin breakdown" EXACT [GOC:TermGenie] synonym: "emodin catabolism" EXACT [GOC:TermGenie] synonym: "emodin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900573 ! emodin metabolic process is_a: GO:1901662 ! quinone catabolic process created_by: di creation_date: 2012-05-15T06:42:06Z [Term] id: GO:1900575 name: emodin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of emodin." [GOC:di, GOC:TermGenie] synonym: "emodin anabolism" EXACT [GOC:TermGenie] synonym: "emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "emodin formation" EXACT [GOC:TermGenie] synonym: "emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900573 ! emodin metabolic process is_a: GO:1901663 ! quinone biosynthetic process created_by: di creation_date: 2012-05-15T06:42:14Z [Term] id: GO:1900576 name: gerfelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gerfelin." [GOC:di, GOC:TermGenie] synonym: "gerfelin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: di creation_date: 2012-05-15T06:42:19Z [Term] id: GO:1900577 name: gerfelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gerfelin." [GOC:di, GOC:TermGenie] synonym: "gerfelin breakdown" EXACT [GOC:TermGenie] synonym: "gerfelin catabolism" EXACT [GOC:TermGenie] synonym: "gerfelin degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900576 ! gerfelin metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-05-15T06:42:39Z [Term] id: GO:1900578 name: gerfelin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gerfelin." [GOC:di, GOC:TermGenie] synonym: "gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "gerfelin formation" EXACT [GOC:TermGenie] synonym: "gerfelin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900576 ! gerfelin metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-05-15T06:42:47Z [Term] id: GO:1900579 name: (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: di creation_date: 2012-05-15T06:47:07Z [Term] id: GO:1900580 name: (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol breakdown" EXACT [GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol catabolism" EXACT [GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol degradation" EXACT [GOC:TermGenie] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process created_by: di creation_date: 2012-05-15T06:47:30Z [Term] id: GO:1900581 name: (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol anabolism" EXACT [GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis" EXACT [GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol formation" EXACT [GOC:TermGenie] synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol synthesis" EXACT [GOC:TermGenie] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0010686 ! tetracyclic triterpenoid biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: di creation_date: 2012-05-15T06:47:38Z [Term] id: GO:1900582 name: o-orsellinic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving o-orsellinic acid." [GOC:di, GOC:TermGenie] synonym: "o-orsellinic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: di creation_date: 2012-05-15T06:47:42Z [Term] id: GO:1900583 name: o-orsellinic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid." [GOC:di, GOC:TermGenie] synonym: "o-orsellinic acid breakdown" EXACT [GOC:TermGenie] synonym: "o-orsellinic acid catabolism" EXACT [GOC:TermGenie] synonym: "o-orsellinic acid degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900582 ! o-orsellinic acid metabolic process created_by: di creation_date: 2012-05-15T06:48:04Z [Term] id: GO:1900584 name: o-orsellinic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of o-orsellinic acid." [GOC:di, GOC:TermGenie] synonym: "o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "o-orsellinic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900582 ! o-orsellinic acid metabolic process created_by: di creation_date: 2012-05-15T06:48:11Z [Term] id: GO:1900585 name: arugosin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arugosin." [GOC:di, GOC:TermGenie] synonym: "arugosin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: di creation_date: 2012-05-15T06:48:15Z [Term] id: GO:1900586 name: arugosin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arugosin." [GOC:di, GOC:TermGenie] synonym: "arugosin breakdown" EXACT [GOC:TermGenie] synonym: "arugosin catabolism" EXACT [GOC:TermGenie] synonym: "arugosin degradation" EXACT [GOC:TermGenie] is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900585 ! arugosin metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: di creation_date: 2012-05-15T06:48:37Z [Term] id: GO:1900587 name: arugosin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arugosin." [GOC:di, GOC:TermGenie] synonym: "arugosin anabolism" EXACT [GOC:TermGenie] synonym: "arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "arugosin formation" EXACT [GOC:TermGenie] synonym: "arugosin synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900585 ! arugosin metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: di creation_date: 2012-05-15T06:48:45Z [Term] id: GO:1900588 name: violaceol I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:TermGenie] synonym: "violaceol I metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0043385 ! mycotoxin metabolic process created_by: di creation_date: 2012-05-15T06:50:48Z [Term] id: GO:1900589 name: violaceol I catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of violaceol I." [GOC:di, GOC:TermGenie] synonym: "violaceol I breakdown" EXACT [GOC:TermGenie] synonym: "violaceol I catabolism" EXACT [GOC:TermGenie] synonym: "violaceol I degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900588 ! violaceol I metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-05-15T06:51:09Z [Term] id: GO:1900590 name: violaceol I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of violaceol I." [GOC:di, GOC:TermGenie] synonym: "violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "violaceol I formation" EXACT [GOC:TermGenie] synonym: "violaceol I synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:1900588 ! violaceol I metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-05-15T06:51:16Z [Term] id: GO:1900591 name: violaceol II metabolic process namespace: biological_process def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC:TermGenie] synonym: "violaceol II metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0043385 ! mycotoxin metabolic process created_by: di creation_date: 2012-05-15T06:51:21Z [Term] id: GO:1900592 name: violaceol II catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of violaceol II." [GOC:di, GOC:TermGenie] synonym: "violaceol II breakdown" EXACT [GOC:TermGenie] synonym: "violaceol II catabolism" EXACT [GOC:TermGenie] synonym: "violaceol II degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900591 ! violaceol II metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-05-15T06:51:43Z [Term] id: GO:1900593 name: violaceol II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of violaceol II." [GOC:di, GOC:TermGenie] synonym: "violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "violaceol II formation" EXACT [GOC:TermGenie] synonym: "violaceol II synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:1900591 ! violaceol II metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-05-15T06:51:51Z [Term] id: GO:1900594 name: (+)-kotanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-kotanin." [GOC:di, GOC:TermGenie] synonym: "(+)-kotanin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-05-15T06:54:19Z [Term] id: GO:1900595 name: (+)-kotanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-kotanin." [GOC:di, GOC:TermGenie] synonym: "(+)-kotanin breakdown" EXACT [GOC:TermGenie] synonym: "(+)-kotanin catabolism" EXACT [GOC:TermGenie] synonym: "(+)-kotanin degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900594 ! (+)-kotanin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T06:54:40Z [Term] id: GO:1900596 name: (+)-kotanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-kotanin." [GOC:di, GOC:TermGenie] synonym: "(+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "(+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "(+)-kotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900594 ! (+)-kotanin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T06:54:47Z [Term] id: GO:1900597 name: demethylkotanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving demethylkotanin." [GOC:di, GOC:TermGenie] synonym: "demethylkotanin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-05-15T06:54:52Z [Term] id: GO:1900598 name: demethylkotanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of demethylkotanin." [GOC:di, GOC:TermGenie] synonym: "demethylkotanin breakdown" EXACT [GOC:TermGenie] synonym: "demethylkotanin catabolism" EXACT [GOC:TermGenie] synonym: "demethylkotanin degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900597 ! demethylkotanin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T06:55:14Z [Term] id: GO:1900599 name: demethylkotanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of demethylkotanin." [GOC:di, GOC:TermGenie] synonym: "demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "demethylkotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900597 ! demethylkotanin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T06:55:21Z [Term] id: GO:1900600 name: endocrocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving endocrocin." [GOC:di, GOC:TermGenie] synonym: "endocrocin metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: di creation_date: 2012-05-15T06:57:14Z [Term] id: GO:1900601 name: endocrocin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of endocrocin." [GOC:di, GOC:TermGenie] synonym: "endocrocin breakdown" EXACT [GOC:TermGenie] synonym: "endocrocin catabolism" EXACT [GOC:TermGenie] synonym: "endocrocin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900600 ! endocrocin metabolic process is_a: GO:1901662 ! quinone catabolic process created_by: di creation_date: 2012-05-15T06:57:34Z [Term] id: GO:1900602 name: endocrocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of endocrocin." [GOC:di, GOC:TermGenie] synonym: "endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "endocrocin formation" EXACT [GOC:TermGenie] synonym: "endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900600 ! endocrocin metabolic process is_a: GO:1901663 ! quinone biosynthetic process created_by: di creation_date: 2012-05-15T06:57:42Z [Term] id: GO:1900603 name: tensidol A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie] synonym: "tensidol A metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: di creation_date: 2012-05-15T06:57:47Z [Term] id: GO:1900604 name: tensidol A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tensidol A." [GOC:di, GOC:TermGenie] synonym: "tensidol A breakdown" EXACT [GOC:TermGenie] synonym: "tensidol A catabolism" EXACT [GOC:TermGenie] synonym: "tensidol A degradation" EXACT [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900603 ! tensidol A metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: di creation_date: 2012-05-15T06:58:09Z [Term] id: GO:1900605 name: tensidol A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tensidol A." [GOC:di, GOC:TermGenie] synonym: "tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "tensidol A formation" EXACT [GOC:TermGenie] synonym: "tensidol A synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900603 ! tensidol A metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: di creation_date: 2012-05-15T06:58:16Z [Term] id: GO:1900606 name: tensidol B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tensidol B." [GOC:di, GOC:TermGenie] synonym: "tensidol B metabolism" EXACT [GOC:TermGenie] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-05-15T06:58:21Z [Term] id: GO:1900607 name: tensidol B catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tensidol B." [GOC:di, GOC:TermGenie] synonym: "tensidol B breakdown" EXACT [GOC:TermGenie] synonym: "tensidol B catabolism" EXACT [GOC:TermGenie] synonym: "tensidol B degradation" EXACT [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900606 ! tensidol B metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-05-15T06:58:43Z [Term] id: GO:1900608 name: tensidol B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tensidol B." [GOC:di, GOC:TermGenie] synonym: "tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "tensidol B formation" EXACT [GOC:TermGenie] synonym: "tensidol B synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900606 ! tensidol B metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T06:58:51Z [Term] id: GO:1900609 name: F-9775A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving F-9775A." [GOC:di, GOC:TermGenie] synonym: "F-9775A metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: di creation_date: 2012-05-15T07:02:27Z [Term] id: GO:1900610 name: F-9775A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of F-9775A." [GOC:di, GOC:TermGenie] synonym: "F-9775A breakdown" EXACT [GOC:TermGenie] synonym: "F-9775A catabolism" EXACT [GOC:TermGenie] synonym: "F-9775A degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:1900609 ! F-9775A metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process created_by: di creation_date: 2012-05-15T07:02:49Z [Term] id: GO:1900611 name: F-9775A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of F-9775A." [GOC:di, GOC:TermGenie] synonym: "F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "F-9775A formation" EXACT [GOC:TermGenie] synonym: "F-9775A synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900609 ! F-9775A metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T07:02:56Z [Term] id: GO:1900612 name: F-9775B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving F-9775B." [GOC:di, GOC:TermGenie] synonym: "F-9775B metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: di creation_date: 2012-05-15T07:03:01Z [Term] id: GO:1900613 name: F-9775B catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of F-9775B." [GOC:di, GOC:TermGenie] synonym: "F-9775B breakdown" EXACT [GOC:TermGenie] synonym: "F-9775B catabolism" EXACT [GOC:TermGenie] synonym: "F-9775B degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:1900612 ! F-9775B metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process created_by: di creation_date: 2012-05-15T07:03:24Z [Term] id: GO:1900614 name: F-9775B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of F-9775B." [GOC:di, GOC:TermGenie] synonym: "F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "F-9775B formation" EXACT [GOC:TermGenie] synonym: "F-9775B synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900612 ! F-9775B metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process created_by: di creation_date: 2012-05-15T07:03:32Z [Term] id: GO:1900615 name: emericellamide A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving emericellamide A." [GOC:di, GOC:TermGenie] synonym: "emericellamide A metabolism" EXACT [GOC:TermGenie] is_a: GO:1900555 ! emericellamide metabolic process created_by: di creation_date: 2012-05-15T07:59:59Z [Term] id: GO:1900616 name: emericellamide A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of emericellamide A." [GOC:di, GOC:TermGenie] synonym: "emericellamide A breakdown" EXACT [GOC:TermGenie] synonym: "emericellamide A catabolism" EXACT [GOC:TermGenie] synonym: "emericellamide A degradation" EXACT [GOC:TermGenie] is_a: GO:1900556 ! emericellamide catabolic process is_a: GO:1900615 ! emericellamide A metabolic process created_by: di creation_date: 2012-05-15T08:00:19Z [Term] id: GO:1900617 name: emericellamide A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of emericellamide A." [GOC:di, GOC:TermGenie] synonym: "emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "emericellamide A formation" EXACT [GOC:TermGenie] synonym: "emericellamide A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900557 ! emericellamide biosynthetic process is_a: GO:1900615 ! emericellamide A metabolic process created_by: di creation_date: 2012-05-15T08:00:27Z [Term] id: GO:1900618 name: regulation of shoot system morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shoot morphogenesis." [GOC:TermGenie] synonym: "regulation of shoot morphogenesis" EXACT [] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048831 ! regulation of shoot system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010016 ! shoot system morphogenesis relationship: regulates GO:0010016 ! shoot system morphogenesis created_by: tb creation_date: 2012-05-15T09:24:37Z [Term] id: GO:1900619 name: acetate ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie] synonym: "acetate ester metabolism" EXACT [GOC:TermGenie] synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622] synonym: "acetyl ester metabolism" EXACT [CHEBI:47622] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-05-16T12:29:51Z [Term] id: GO:1900620 name: acetate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596] synonym: "acetate ester anabolism" EXACT [GOC:TermGenie] synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "acetate ester formation" EXACT [GOC:TermGenie] synonym: "acetate ester synthesis" EXACT [GOC:TermGenie] synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622] synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622] is_a: GO:1900619 ! acetate ester metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-05-16T12:30:12Z [Term] id: GO:1900621 name: obsolete regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling namespace: biological_process def: "OBSOLETE. Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:TermGenie] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-05-18T01:00:39Z [Term] id: GO:1900622 name: positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling namespace: biological_process def: "Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter." [GOC:bf, GOC:BHF, GOC:dgf, GOC:TermGenie, PMID:9407035, PMID:9407036] comment: To be obsoleted, see https://github.com/geneontology/go-ontology/issues/12739. However, need to capture the calcium-mediated signaling pathway that has part regulation of transcription. See PMID:9407035 and PMID:9407036. synonym: "activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "calcineurin-dependent transcription activation" NARROW [PMID:9407036] synonym: "calcineurin-dependent transcriptional induction" NARROW [PMID:9407035] synonym: "calcineurin-mediated activation of transcription" NARROW [PMID:9407035] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0019722 ! calcium-mediated signaling intersection_of: positively_regulates GO:0006366 ! transcription by RNA polymerase II created_by: bf creation_date: 2012-05-18T01:01:04Z [Term] id: GO:1900623 name: regulation of monocyte aggregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070487 ! monocyte aggregation relationship: regulates GO:0070487 ! monocyte aggregation created_by: vk creation_date: 2012-05-21T01:07:17Z [Term] id: GO:1900624 name: negative regulation of monocyte aggregation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "down regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "down-regulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "down-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "downregulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "downregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "inhibition of monocyte aggregation" NARROW [GOC:TermGenie] synonym: "inhibition of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "negative regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] is_a: GO:1900623 ! regulation of monocyte aggregation is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070487 ! monocyte aggregation relationship: negatively_regulates GO:0070487 ! monocyte aggregation created_by: vk creation_date: 2012-05-21T01:07:37Z [Term] id: GO:1900625 name: positive regulation of monocyte aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] synonym: "activation of monocyte aggregation" NARROW [GOC:TermGenie] synonym: "activation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "positive regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of monocyte aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] is_a: GO:1900623 ! regulation of monocyte aggregation is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070487 ! monocyte aggregation relationship: positively_regulates GO:0070487 ! monocyte aggregation created_by: vk creation_date: 2012-05-21T01:07:44Z [Term] id: GO:1900626 name: regulation of arugosin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "regulation of arugosin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900587 ! arugosin biosynthetic process relationship: regulates GO:1900587 ! arugosin biosynthetic process created_by: di creation_date: 2012-05-21T05:47:39Z [Term] id: GO:1900627 name: negative regulation of arugosin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "down regulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "downregulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of arugosin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of arugosin formation" EXACT [GOC:TermGenie] synonym: "inhibition of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of arugosin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900626 ! regulation of arugosin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900587 ! arugosin biosynthetic process relationship: negatively_regulates GO:1900587 ! arugosin biosynthetic process created_by: di creation_date: 2012-05-21T05:48:03Z [Term] id: GO:1900628 name: positive regulation of arugosin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "activation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of arugosin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of arugosin formation" EXACT [GOC:TermGenie] synonym: "activation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "up regulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of arugosin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of arugosin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of arugosin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of arugosin formation" EXACT [GOC:TermGenie] synonym: "upregulation of arugosin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900626 ! regulation of arugosin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900587 ! arugosin biosynthetic process relationship: positively_regulates GO:1900587 ! arugosin biosynthetic process created_by: di creation_date: 2012-05-21T05:48:11Z [Term] id: GO:1900629 name: methanophenazine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanophenazine." [GOC:mengo_curators, GOC:TermGenie] synonym: "methanophenazine metabolism" EXACT [GOC:TermGenie] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: tt creation_date: 2012-05-21T06:12:07Z [Term] id: GO:1900630 name: methanophenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methanophenazine." [GOC:mengo_curators, GOC:TermGenie] synonym: "methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "methanophenazine formation" EXACT [GOC:TermGenie] synonym: "methanophenazine synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1900629 ! methanophenazine metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: tt creation_date: 2012-05-21T06:12:30Z [Term] id: GO:1900631 name: tridecane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tridecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "tridecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0043446 ! cellular alkane metabolic process created_by: tt creation_date: 2012-05-21T06:41:16Z [Term] id: GO:1900632 name: tridecane biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tridecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "tridecane anabolism" EXACT [GOC:TermGenie] synonym: "tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "tridecane formation" EXACT [GOC:TermGenie] synonym: "tridecane synthesis" EXACT [GOC:TermGenie] is_a: GO:0043447 ! alkane biosynthetic process is_a: GO:1900631 ! tridecane metabolic process created_by: tt creation_date: 2012-05-21T06:41:37Z [Term] id: GO:1900633 name: pentadecane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentadecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "pentadecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0043446 ! cellular alkane metabolic process created_by: tt creation_date: 2012-05-21T06:51:34Z [Term] id: GO:1900634 name: pentadecane biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentadecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "pentadecane anabolism" EXACT [GOC:TermGenie] synonym: "pentadecane biosynthesis" EXACT [GOC:TermGenie] synonym: "pentadecane formation" EXACT [GOC:TermGenie] synonym: "pentadecane synthesis" EXACT [GOC:TermGenie] is_a: GO:0043447 ! alkane biosynthetic process is_a: GO:1900633 ! pentadecane metabolic process created_by: tt creation_date: 2012-05-21T06:51:57Z [Term] id: GO:1900635 name: heptadecane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heptadecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "heptadecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0043446 ! cellular alkane metabolic process created_by: tt creation_date: 2012-05-21T07:05:01Z [Term] id: GO:1900636 name: heptadecane biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heptadecane." [GOC:mengo_curators, GOC:TermGenie] synonym: "heptadecane anabolism" EXACT [GOC:TermGenie] synonym: "heptadecane biosynthesis" EXACT [GOC:TermGenie] synonym: "heptadecane formation" EXACT [GOC:TermGenie] synonym: "heptadecane synthesis" EXACT [GOC:TermGenie] is_a: GO:0043447 ! alkane biosynthetic process is_a: GO:1900635 ! heptadecane metabolic process created_by: tt creation_date: 2012-05-21T07:05:21Z [Term] id: GO:1900637 name: regulation of asperfuranone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] is_a: GO:1900732 ! regulation of polyketide biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900554 ! asperfuranone biosynthetic process relationship: regulates GO:1900554 ! asperfuranone biosynthetic process created_by: di creation_date: 2012-05-22T03:49:55Z [Term] id: GO:1900638 name: negative regulation of asperfuranone biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "down regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "down-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "downregulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of asperfuranone biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "inhibition of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "negative regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process relationship: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process created_by: di creation_date: 2012-05-22T03:50:16Z [Term] id: GO:1900639 name: positive regulation of asperfuranone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "activation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of asperfuranone biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "activation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "positive regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "up regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "up-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of asperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of asperfuranone formation" EXACT [GOC:TermGenie] synonym: "upregulation of asperfuranone synthesis" EXACT [GOC:TermGenie] is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900554 ! asperfuranone biosynthetic process relationship: positively_regulates GO:1900554 ! asperfuranone biosynthetic process created_by: di creation_date: 2012-05-22T03:50:24Z [Term] id: GO:1900640 name: regulation of austinol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "regulation of austinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900560 ! austinol biosynthetic process relationship: regulates GO:1900560 ! austinol biosynthetic process created_by: di creation_date: 2012-05-22T03:57:33Z [Term] id: GO:1900641 name: negative regulation of austinol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "down regulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of austinol formation" EXACT [GOC:TermGenie] synonym: "downregulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of austinol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of austinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of austinol formation" EXACT [GOC:TermGenie] synonym: "inhibition of austinol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of austinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1900640 ! regulation of austinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900560 ! austinol biosynthetic process relationship: negatively_regulates GO:1900560 ! austinol biosynthetic process created_by: di creation_date: 2012-05-22T03:57:59Z [Term] id: GO:1900642 name: positive regulation of austinol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "activation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of austinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of austinol formation" EXACT [GOC:TermGenie] synonym: "activation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "up regulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of austinol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of austinol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of austinol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of austinol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of austinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of austinol formation" EXACT [GOC:TermGenie] synonym: "upregulation of austinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1900640 ! regulation of austinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900560 ! austinol biosynthetic process relationship: positively_regulates GO:1900560 ! austinol biosynthetic process created_by: di creation_date: 2012-05-22T03:58:07Z [Term] id: GO:1900643 name: regulation of chanoclavine-I biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900566 ! chanoclavine-I biosynthetic process relationship: regulates GO:1900566 ! chanoclavine-I biosynthetic process created_by: di creation_date: 2012-05-22T04:03:08Z [Term] id: GO:1900644 name: negative regulation of chanoclavine-I biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900566 ! chanoclavine-I biosynthetic process relationship: negatively_regulates GO:1900566 ! chanoclavine-I biosynthetic process created_by: di creation_date: 2012-05-22T04:03:30Z [Term] id: GO:1900645 name: positive regulation of chanoclavine-I biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I formation" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900566 ! chanoclavine-I biosynthetic process relationship: positively_regulates GO:1900566 ! chanoclavine-I biosynthetic process created_by: di creation_date: 2012-05-22T04:03:38Z [Term] id: GO:1900646 name: regulation of chanoclavine-I aldehyde biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process relationship: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process created_by: di creation_date: 2012-05-22T04:04:38Z [Term] id: GO:1900647 name: negative regulation of chanoclavine-I aldehyde biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "down regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "down-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "downregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "inhibition of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "negative regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process relationship: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process created_by: di creation_date: 2012-05-22T04:04:59Z [Term] id: GO:1900648 name: positive regulation of chanoclavine-I aldehyde biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "activation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "positive regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "up regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "up-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] synonym: "upregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process relationship: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process created_by: di creation_date: 2012-05-22T04:05:06Z [Term] id: GO:1900649 name: regulation of dehydroaustinol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900563 ! dehydroaustinol biosynthetic process relationship: regulates GO:1900563 ! dehydroaustinol biosynthetic process created_by: di creation_date: 2012-05-22T04:06:03Z [Term] id: GO:1900650 name: negative regulation of dehydroaustinol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "down regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "downregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "inhibition of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process relationship: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process created_by: di creation_date: 2012-05-22T04:06:22Z [Term] id: GO:1900651 name: positive regulation of dehydroaustinol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "activation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "activation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "up regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of dehydroaustinol formation" EXACT [GOC:TermGenie] synonym: "upregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process relationship: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process created_by: di creation_date: 2012-05-22T04:06:30Z [Term] id: GO:1900652 name: regulation of demethylkotanin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900599 ! demethylkotanin biosynthetic process relationship: regulates GO:1900599 ! demethylkotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:07:18Z [Term] id: GO:1900653 name: negative regulation of demethylkotanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "down regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "downregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "inhibition of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process relationship: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:07:41Z [Term] id: GO:1900654 name: positive regulation of demethylkotanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "activation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "activation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "up regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of demethylkotanin formation" EXACT [GOC:TermGenie] synonym: "upregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process relationship: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:07:49Z [Term] id: GO:1900655 name: regulation of diorcinol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "regulation of diorcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900572 ! diorcinol biosynthetic process relationship: regulates GO:1900572 ! diorcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:08:40Z [Term] id: GO:1900656 name: negative regulation of diorcinol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "down regulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "downregulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of diorcinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of diorcinol formation" EXACT [GOC:TermGenie] synonym: "inhibition of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of diorcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900655 ! regulation of diorcinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900572 ! diorcinol biosynthetic process relationship: negatively_regulates GO:1900572 ! diorcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:09:01Z [Term] id: GO:1900657 name: positive regulation of diorcinol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "activation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of diorcinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "activation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "up regulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of diorcinol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of diorcinol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of diorcinol formation" EXACT [GOC:TermGenie] synonym: "upregulation of diorcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900655 ! regulation of diorcinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900572 ! diorcinol biosynthetic process relationship: positively_regulates GO:1900572 ! diorcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:09:08Z [Term] id: GO:1900658 name: regulation of emericellamide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900557 ! emericellamide biosynthetic process relationship: regulates GO:1900557 ! emericellamide biosynthetic process created_by: di creation_date: 2012-05-22T04:10:19Z [Term] id: GO:1900659 name: negative regulation of emericellamide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of emericellamide formation" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900658 ! regulation of emericellamide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900557 ! emericellamide biosynthetic process relationship: negatively_regulates GO:1900557 ! emericellamide biosynthetic process created_by: di creation_date: 2012-05-22T04:10:44Z [Term] id: GO:1900660 name: positive regulation of emericellamide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "activation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of emericellamide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "activation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide formation" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900658 ! regulation of emericellamide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900557 ! emericellamide biosynthetic process relationship: positively_regulates GO:1900557 ! emericellamide biosynthetic process created_by: di creation_date: 2012-05-22T04:10:51Z [Term] id: GO:1900661 name: regulation of emericellamide A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900658 ! regulation of emericellamide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900617 ! emericellamide A biosynthetic process relationship: regulates GO:1900617 ! emericellamide A biosynthetic process created_by: di creation_date: 2012-05-22T04:13:07Z [Term] id: GO:1900662 name: negative regulation of emericellamide A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "down regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "downregulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide A biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "inhibition of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "negative regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900659 ! negative regulation of emericellamide biosynthetic process is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process relationship: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process created_by: di creation_date: 2012-05-22T04:13:28Z [Term] id: GO:1900663 name: positive regulation of emericellamide A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "activation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of emericellamide A biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "activation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "positive regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "up regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "up-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide A anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide A formation" EXACT [GOC:TermGenie] synonym: "upregulation of emericellamide A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900660 ! positive regulation of emericellamide biosynthetic process is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900617 ! emericellamide A biosynthetic process relationship: positively_regulates GO:1900617 ! emericellamide A biosynthetic process created_by: di creation_date: 2012-05-22T04:13:36Z [Term] id: GO:1900664 name: regulation of emodin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900575 ! emodin biosynthetic process relationship: regulates GO:1900575 ! emodin biosynthetic process created_by: di creation_date: 2012-05-22T04:14:36Z [Term] id: GO:1900665 name: negative regulation of emodin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "down regulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of emodin formation" EXACT [GOC:TermGenie] synonym: "downregulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emodin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of emodin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of emodin formation" EXACT [GOC:TermGenie] synonym: "inhibition of emodin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900664 ! regulation of emodin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900575 ! emodin biosynthetic process relationship: negatively_regulates GO:1900575 ! emodin biosynthetic process created_by: di creation_date: 2012-05-22T04:14:58Z [Term] id: GO:1900666 name: positive regulation of emodin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "activation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of emodin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of emodin formation" EXACT [GOC:TermGenie] synonym: "activation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "up regulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of emodin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emodin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie] synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900664 ! regulation of emodin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900575 ! emodin biosynthetic process relationship: positively_regulates GO:1900575 ! emodin biosynthetic process created_by: di creation_date: 2012-05-22T04:15:06Z [Term] id: GO:1900667 name: regulation of endocrocin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900602 ! endocrocin biosynthetic process relationship: regulates GO:1900602 ! endocrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:16:04Z [Term] id: GO:1900668 name: negative regulation of endocrocin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "down regulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "downregulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of endocrocin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of endocrocin formation" EXACT [GOC:TermGenie] synonym: "inhibition of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900667 ! regulation of endocrocin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900602 ! endocrocin biosynthetic process relationship: negatively_regulates GO:1900602 ! endocrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:16:25Z [Term] id: GO:1900669 name: positive regulation of endocrocin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "activation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of endocrocin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "activation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "up regulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of endocrocin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900667 ! regulation of endocrocin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900602 ! endocrocin biosynthetic process relationship: positively_regulates GO:1900602 ! endocrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:16:35Z [Term] id: GO:1900670 name: regulation of F-9775A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "regulation of F-9775A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900732 ! regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900611 ! F-9775A biosynthetic process relationship: regulates GO:1900611 ! F-9775A biosynthetic process created_by: di creation_date: 2012-05-22T04:24:09Z [Term] id: GO:1900671 name: negative regulation of F-9775A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775A biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of F-9775A formation" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900670 ! regulation of F-9775A biosynthetic process is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900611 ! F-9775A biosynthetic process relationship: negatively_regulates GO:1900611 ! F-9775A biosynthetic process created_by: di creation_date: 2012-05-22T04:24:30Z [Term] id: GO:1900672 name: positive regulation of F-9775A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "activation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of F-9775A biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "activation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775A synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775A anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775A formation" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900670 ! regulation of F-9775A biosynthetic process is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900611 ! F-9775A biosynthetic process relationship: positively_regulates GO:1900611 ! F-9775A biosynthetic process created_by: di creation_date: 2012-05-22T04:24:37Z [Term] id: GO:1900673 name: olefin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving olefin." [GOC:mengo_curators, GOC:TermGenie] synonym: "olefin metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: tt creation_date: 2012-05-22T04:24:42Z [Term] id: GO:1900674 name: olefin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of olefin." [GOC:mengo_curators, GOC:TermGenie] synonym: "olefin anabolism" EXACT [GOC:TermGenie] synonym: "olefin biosynthesis" EXACT [GOC:TermGenie] synonym: "olefin formation" EXACT [GOC:TermGenie] synonym: "olefin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: tt creation_date: 2012-05-22T04:25:03Z [Term] id: GO:1900675 name: regulation of F-9775B biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "regulation of F-9775B synthesis" EXACT [GOC:TermGenie] is_a: GO:1900732 ! regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900614 ! F-9775B biosynthetic process relationship: regulates GO:1900614 ! F-9775B biosynthetic process created_by: di creation_date: 2012-05-22T04:26:31Z [Term] id: GO:1900676 name: negative regulation of F-9775B biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "down regulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "down-regulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "downregulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775B biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of F-9775B formation" EXACT [GOC:TermGenie] synonym: "inhibition of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "negative regulation of F-9775B synthesis" EXACT [GOC:TermGenie] is_a: GO:1900675 ! regulation of F-9775B biosynthetic process is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900614 ! F-9775B biosynthetic process relationship: negatively_regulates GO:1900614 ! F-9775B biosynthetic process created_by: di creation_date: 2012-05-22T04:26:53Z [Term] id: GO:1900677 name: positive regulation of F-9775B biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "activation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of F-9775B biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "activation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "positive regulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "up regulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "up-regulation of F-9775B synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775B anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775B formation" EXACT [GOC:TermGenie] synonym: "upregulation of F-9775B synthesis" EXACT [GOC:TermGenie] is_a: GO:1900675 ! regulation of F-9775B biosynthetic process is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900614 ! F-9775B biosynthetic process relationship: positively_regulates GO:1900614 ! F-9775B biosynthetic process created_by: di creation_date: 2012-05-22T04:27:01Z [Term] id: GO:1900678 name: regulation of ferricrocin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031171 ! ferricrocin biosynthetic process relationship: regulates GO:0031171 ! ferricrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:27:53Z [Term] id: GO:1900679 name: negative regulation of ferricrocin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "down regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down-regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "downregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "downregulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "downregulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ferricrocin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "inhibition of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "inhibition of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "inhibition of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "negative regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "negative regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process relationship: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:28:15Z [Term] id: GO:1900680 name: positive regulation of ferricrocin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "activation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of ferricrocin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "activation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "activation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "activation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "positive regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "positive regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "up regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up-regulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ferricrocin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "upregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "upregulation of ferricrocin formation" EXACT [GOC:TermGenie] synonym: "upregulation of ferricrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process is_a: GO:1905570 ! positive regulation of ferrichrome biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031171 ! ferricrocin biosynthetic process relationship: positively_regulates GO:0031171 ! ferricrocin biosynthetic process created_by: di creation_date: 2012-05-22T04:28:23Z [Term] id: GO:1900681 name: octadecene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octadecene." [GOC:mengo_curators, GOC:TermGenie] synonym: "octadecene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-05-22T04:28:28Z [Term] id: GO:1900682 name: octadecene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octadecene." [GOC:mengo_curators, GOC:TermGenie] synonym: "1-octadecene biosynthetic process" EXACT [GOC:mengo_curators] synonym: "octadecene anabolism" EXACT [GOC:TermGenie] synonym: "octadecene biosynthesis" EXACT [GOC:TermGenie] synonym: "octadecene formation" EXACT [GOC:TermGenie] synonym: "octadecene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900681 ! octadecene metabolic process created_by: tt creation_date: 2012-05-22T04:28:49Z [Term] id: GO:1900683 name: regulation of fumonisin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "regulation of fumonisin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900541 ! fumonisin biosynthetic process relationship: regulates GO:1900541 ! fumonisin biosynthetic process created_by: di creation_date: 2012-05-22T04:29:38Z [Term] id: GO:1900684 name: negative regulation of fumonisin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "down regulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "downregulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of fumonisin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of fumonisin formation" EXACT [GOC:TermGenie] synonym: "inhibition of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of fumonisin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900683 ! regulation of fumonisin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900541 ! fumonisin biosynthetic process relationship: negatively_regulates GO:1900541 ! fumonisin biosynthetic process created_by: di creation_date: 2012-05-22T04:29:59Z [Term] id: GO:1900685 name: positive regulation of fumonisin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "activation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of fumonisin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "activation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "up regulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of fumonisin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of fumonisin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of fumonisin formation" EXACT [GOC:TermGenie] synonym: "upregulation of fumonisin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900683 ! regulation of fumonisin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900541 ! fumonisin biosynthetic process relationship: positively_regulates GO:1900541 ! fumonisin biosynthetic process created_by: di creation_date: 2012-05-22T04:30:06Z [Term] id: GO:1900686 name: regulation of gerfelin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "regulation of gerfelin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900578 ! gerfelin biosynthetic process relationship: regulates GO:1900578 ! gerfelin biosynthetic process created_by: di creation_date: 2012-05-22T04:49:44Z [Term] id: GO:1900687 name: negative regulation of gerfelin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "down regulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "downregulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of gerfelin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of gerfelin formation" EXACT [GOC:TermGenie] synonym: "inhibition of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of gerfelin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900686 ! regulation of gerfelin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900578 ! gerfelin biosynthetic process relationship: negatively_regulates GO:1900578 ! gerfelin biosynthetic process created_by: di creation_date: 2012-05-22T04:50:05Z [Term] id: GO:1900688 name: positive regulation of gerfelin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "activation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of gerfelin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "activation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "up regulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of gerfelin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of gerfelin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of gerfelin formation" EXACT [GOC:TermGenie] synonym: "upregulation of gerfelin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900686 ! regulation of gerfelin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900578 ! gerfelin biosynthetic process relationship: positively_regulates GO:1900578 ! gerfelin biosynthetic process created_by: di creation_date: 2012-05-22T04:50:12Z [Term] id: GO:1900689 name: regulation of gliotoxin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001310 ! gliotoxin biosynthetic process relationship: regulates GO:2001310 ! gliotoxin biosynthetic process created_by: di creation_date: 2012-05-22T04:51:38Z [Term] id: GO:1900690 name: negative regulation of gliotoxin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "down regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "downregulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of gliotoxin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "inhibition of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process relationship: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process created_by: di creation_date: 2012-05-22T04:52:00Z [Term] id: GO:1900691 name: positive regulation of gliotoxin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "activation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of gliotoxin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "activation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "up regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of gliotoxin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of gliotoxin formation" EXACT [GOC:TermGenie] synonym: "upregulation of gliotoxin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001310 ! gliotoxin biosynthetic process relationship: positively_regulates GO:2001310 ! gliotoxin biosynthetic process created_by: di creation_date: 2012-05-22T04:52:08Z [Term] id: GO:1900692 name: regulation of (+)-kotanin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900596 ! (+)-kotanin biosynthetic process relationship: regulates GO:1900596 ! (+)-kotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:53:04Z [Term] id: GO:1900693 name: negative regulation of (+)-kotanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "down regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "downregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "inhibition of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process relationship: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:53:26Z [Term] id: GO:1900694 name: positive regulation of (+)-kotanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "activation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "activation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "up regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of (+)-kotanin formation" EXACT [GOC:TermGenie] synonym: "upregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process relationship: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process created_by: di creation_date: 2012-05-22T04:53:33Z [Term] id: GO:1900695 name: regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process relationship: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process created_by: di creation_date: 2012-05-22T04:54:24Z [Term] id: GO:1900696 name: negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "down regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "downregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "inhibition of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process relationship: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process created_by: di creation_date: 2012-05-22T04:54:45Z [Term] id: GO:1900697 name: positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "activation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "up regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] synonym: "upregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process relationship: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process created_by: di creation_date: 2012-05-22T04:54:56Z [Term] id: GO:1900698 name: regulation of o-orsellinic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900584 ! o-orsellinic acid biosynthetic process relationship: regulates GO:1900584 ! o-orsellinic acid biosynthetic process created_by: di creation_date: 2012-05-22T04:56:46Z [Term] id: GO:1900699 name: negative regulation of o-orsellinic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "down regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "downregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "inhibition of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process relationship: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process created_by: di creation_date: 2012-05-22T04:57:08Z [Term] id: GO:1900700 name: positive regulation of o-orsellinic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "activation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "activation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "up regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] synonym: "upregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process relationship: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process created_by: di creation_date: 2012-05-22T04:57:16Z [Term] id: GO:1900701 name: regulation of orcinol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "regulation of orcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046197 ! orcinol biosynthetic process relationship: regulates GO:0046197 ! orcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:57:59Z [Term] id: GO:1900702 name: negative regulation of orcinol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "down regulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "downregulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of orcinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of orcinol formation" EXACT [GOC:TermGenie] synonym: "inhibition of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of orcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900701 ! regulation of orcinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046197 ! orcinol biosynthetic process relationship: negatively_regulates GO:0046197 ! orcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:58:20Z [Term] id: GO:1900703 name: positive regulation of orcinol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "activation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of orcinol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of orcinol formation" EXACT [GOC:TermGenie] synonym: "activation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "up regulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of orcinol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of orcinol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of orcinol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of orcinol formation" EXACT [GOC:TermGenie] synonym: "upregulation of orcinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900701 ! regulation of orcinol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046197 ! orcinol biosynthetic process relationship: positively_regulates GO:0046197 ! orcinol biosynthetic process created_by: di creation_date: 2012-05-22T04:58:28Z [Term] id: GO:1900704 name: regulation of siderophore biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019290 ! siderophore biosynthetic process relationship: regulates GO:0019290 ! siderophore biosynthetic process created_by: di creation_date: 2012-05-22T04:59:28Z [Term] id: GO:1900705 name: negative regulation of siderophore biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "down regulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down-regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "down-regulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "downregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "downregulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "downregulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of siderophore biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "inhibition of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "inhibition of siderophore formation" EXACT [GOC:TermGenie] synonym: "inhibition of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "negative regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900704 ! regulation of siderophore biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019290 ! siderophore biosynthetic process relationship: negatively_regulates GO:0019290 ! siderophore biosynthetic process created_by: di creation_date: 2012-05-22T04:59:49Z [Term] id: GO:1900706 name: positive regulation of siderophore biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "activation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of siderophore biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "activation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "activation of siderophore formation" EXACT [GOC:TermGenie] synonym: "activation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "positive regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "positive regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "positive regulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "up regulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up-regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "up-regulation of siderophore synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of siderophore anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of siderophore biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "upregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900704 ! regulation of siderophore biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019290 ! siderophore biosynthetic process relationship: positively_regulates GO:0019290 ! siderophore biosynthetic process created_by: di creation_date: 2012-05-22T05:00:00Z [Term] id: GO:1900707 name: regulation of tensidol A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "regulation of tensidol A synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900605 ! tensidol A biosynthetic process relationship: regulates GO:1900605 ! tensidol A biosynthetic process created_by: di creation_date: 2012-05-22T05:01:44Z [Term] id: GO:1900708 name: negative regulation of tensidol A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol A biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tensidol A formation" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol A synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900707 ! regulation of tensidol A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900605 ! tensidol A biosynthetic process relationship: negatively_regulates GO:1900605 ! tensidol A biosynthetic process created_by: di creation_date: 2012-05-22T05:02:04Z [Term] id: GO:1900709 name: positive regulation of tensidol A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "activation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of tensidol A biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "activation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol A synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol A anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol A formation" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol A synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900707 ! regulation of tensidol A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900605 ! tensidol A biosynthetic process relationship: positively_regulates GO:1900605 ! tensidol A biosynthetic process created_by: di creation_date: 2012-05-22T05:02:12Z [Term] id: GO:1900710 name: regulation of tensidol B biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "regulation of tensidol B synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900608 ! tensidol B biosynthetic process relationship: regulates GO:1900608 ! tensidol B biosynthetic process created_by: di creation_date: 2012-05-22T05:02:55Z [Term] id: GO:1900711 name: negative regulation of tensidol B biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "down regulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "downregulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol B biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tensidol B formation" EXACT [GOC:TermGenie] synonym: "inhibition of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tensidol B synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900710 ! regulation of tensidol B biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900608 ! tensidol B biosynthetic process relationship: negatively_regulates GO:1900608 ! tensidol B biosynthetic process created_by: di creation_date: 2012-05-22T05:03:16Z [Term] id: GO:1900712 name: positive regulation of tensidol B biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "activation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of tensidol B biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "activation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "up regulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tensidol B synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol B anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol B formation" EXACT [GOC:TermGenie] synonym: "upregulation of tensidol B synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900710 ! regulation of tensidol B biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900608 ! tensidol B biosynthetic process relationship: positively_regulates GO:1900608 ! tensidol B biosynthetic process created_by: di creation_date: 2012-05-22T05:03:23Z [Term] id: GO:1900713 name: regulation of violaceol I biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "regulation of violaceol I synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900590 ! violaceol I biosynthetic process relationship: regulates GO:1900590 ! violaceol I biosynthetic process created_by: di creation_date: 2012-05-22T05:04:12Z [Term] id: GO:1900714 name: negative regulation of violaceol I biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol I biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of violaceol I formation" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol I synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900713 ! regulation of violaceol I biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900590 ! violaceol I biosynthetic process relationship: negatively_regulates GO:1900590 ! violaceol I biosynthetic process created_by: di creation_date: 2012-05-22T05:04:33Z [Term] id: GO:1900715 name: positive regulation of violaceol I biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "activation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of violaceol I biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "activation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol I synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol I anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol I formation" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol I synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900713 ! regulation of violaceol I biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900590 ! violaceol I biosynthetic process relationship: positively_regulates GO:1900590 ! violaceol I biosynthetic process created_by: di creation_date: 2012-05-22T05:04:41Z [Term] id: GO:1900716 name: regulation of violaceol II biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "regulation of violaceol II synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900593 ! violaceol II biosynthetic process relationship: regulates GO:1900593 ! violaceol II biosynthetic process created_by: di creation_date: 2012-05-22T05:05:37Z [Term] id: GO:1900717 name: negative regulation of violaceol II biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "down regulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "down-regulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "downregulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol II biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of violaceol II formation" EXACT [GOC:TermGenie] synonym: "inhibition of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "negative regulation of violaceol II synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900716 ! regulation of violaceol II biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900593 ! violaceol II biosynthetic process relationship: negatively_regulates GO:1900593 ! violaceol II biosynthetic process created_by: di creation_date: 2012-05-22T05:05:58Z [Term] id: GO:1900718 name: positive regulation of violaceol II biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "activation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of violaceol II biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "activation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "positive regulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "up regulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "up-regulation of violaceol II synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol II anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol II formation" EXACT [GOC:TermGenie] synonym: "upregulation of violaceol II synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900716 ! regulation of violaceol II biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900593 ! violaceol II biosynthetic process relationship: positively_regulates GO:1900593 ! violaceol II biosynthetic process created_by: di creation_date: 2012-05-22T05:06:06Z [Term] id: GO:1900719 name: regulation of uterine smooth muscle relaxation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] synonym: "regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] is_a: GO:1901080 ! regulation of relaxation of smooth muscle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044558 ! uterine smooth muscle relaxation relationship: regulates GO:0044558 ! uterine smooth muscle relaxation created_by: jl creation_date: 2012-05-24T03:12:26Z [Term] id: GO:1900720 name: negative regulation of uterine smooth muscle relaxation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] synonym: "down regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "down regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "down-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "downregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "inhibition of uterine smooth muscle relaxation" NARROW [GOC:TermGenie] synonym: "negative regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation is_a: GO:1901081 ! negative regulation of relaxation of smooth muscle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation relationship: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation created_by: jl creation_date: 2012-05-24T03:12:49Z [Term] id: GO:1900721 name: positive regulation of uterine smooth muscle relaxation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] synonym: "activation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "activation of uterine smooth muscle relaxation" NARROW [GOC:TermGenie] synonym: "positive regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "up regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "up regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "up-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] synonym: "upregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation is_a: GO:1901082 ! positive regulation of relaxation of smooth muscle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044558 ! uterine smooth muscle relaxation relationship: positively_regulates GO:0044558 ! uterine smooth muscle relaxation created_by: jl creation_date: 2012-05-24T03:12:57Z [Term] id: GO:1900722 name: regulation of protein adenylylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] synonym: "regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "regulation of protein AMPylation" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018117 ! protein adenylylation relationship: regulates GO:0018117 ! protein adenylylation created_by: jl creation_date: 2012-05-24T03:15:44Z [Term] id: GO:1900723 name: negative regulation of protein adenylylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] synonym: "down regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein adenylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein adenylylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein AMPylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein AMPylation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1900722 ! regulation of protein adenylylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018117 ! protein adenylylation relationship: negatively_regulates GO:0018117 ! protein adenylylation created_by: jl creation_date: 2012-05-24T03:16:06Z [Term] id: GO:1900724 name: positive regulation of protein adenylylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] synonym: "activation of protein adenylation" EXACT [GOC:TermGenie] synonym: "activation of protein adenylylation" NARROW [GOC:TermGenie] synonym: "activation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "activation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein AMPylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein adenylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein adenylylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein AMPylation" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1900722 ! regulation of protein adenylylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018117 ! protein adenylylation relationship: positively_regulates GO:0018117 ! protein adenylylation created_by: jl creation_date: 2012-05-24T03:16:13Z [Term] id: GO:1900725 name: osmoregulated periplasmic glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] synonym: "osmoregulated periplasmic glucan metabolism" EXACT [GOC:TermGenie] is_a: GO:0044042 ! glucan metabolic process created_by: jl creation_date: 2012-05-24T03:18:32Z [Term] id: GO:1900726 name: osmoregulated periplasmic glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] synonym: "osmoregulated periplasmic glucan breakdown" EXACT [GOC:TermGenie] synonym: "osmoregulated periplasmic glucan catabolism" EXACT [GOC:TermGenie] synonym: "osmoregulated periplasmic glucan degradation" EXACT [GOC:TermGenie] is_a: GO:0009251 ! glucan catabolic process is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process created_by: jl creation_date: 2012-05-24T03:18:54Z [Term] id: GO:1900727 name: osmoregulated periplasmic glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] synonym: "osmoregulated periplasmic glucan anabolism" EXACT [GOC:TermGenie] synonym: "osmoregulated periplasmic glucan biosynthesis" EXACT [GOC:TermGenie] synonym: "osmoregulated periplasmic glucan formation" EXACT [GOC:TermGenie] synonym: "osmoregulated periplasmic glucan synthesis" EXACT [GOC:TermGenie] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process created_by: jl creation_date: 2012-05-24T03:19:02Z [Term] id: GO:1900728 name: cardiac neural crest cell delamination involved in outflow tract morphogenesis namespace: biological_process def: "Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis." [GOC:hjd, GOC:TermGenie, PMID:18539270] is_a: GO:0036036 ! cardiac neural crest cell delamination intersection_of: GO:0036036 ! cardiac neural crest cell delamination intersection_of: part_of GO:0003151 ! outflow tract morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: bf creation_date: 2012-05-25T09:50:24Z [Term] id: GO:1900729 name: regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor" RELATED [PMID:17157995] synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie] synonym: "regulation of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] is_a: GO:2000474 ! regulation of opioid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway relationship: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway created_by: bf creation_date: 2012-05-25T03:20:49Z [Term] id: GO:1900730 name: negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] synonym: "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie] is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway is_a: GO:2000475 ! negative regulation of opioid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway relationship: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway created_by: bf creation_date: 2012-05-25T03:21:12Z [Term] id: GO:1900731 name: positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] synonym: "activation of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] synonym: "up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway is_a: GO:2000476 ! positive regulation of opioid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway relationship: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway created_by: bf creation_date: 2012-05-25T03:21:19Z [Term] id: GO:1900732 name: regulation of polyketide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "regulation of polyketide synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030639 ! polyketide biosynthetic process relationship: regulates GO:0030639 ! polyketide biosynthetic process created_by: di creation_date: 2012-05-26T01:29:40Z [Term] id: GO:1900733 name: negative regulation of polyketide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "down regulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "downregulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of polyketide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of polyketide formation" EXACT [GOC:TermGenie] synonym: "inhibition of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of polyketide synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900732 ! regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030639 ! polyketide biosynthetic process relationship: negatively_regulates GO:0030639 ! polyketide biosynthetic process created_by: di creation_date: 2012-05-26T01:30:02Z [Term] id: GO:1900734 name: positive regulation of polyketide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "activation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of polyketide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of polyketide formation" EXACT [GOC:TermGenie] synonym: "activation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "up regulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of polyketide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of polyketide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of polyketide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of polyketide formation" EXACT [GOC:TermGenie] synonym: "upregulation of polyketide synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900732 ! regulation of polyketide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030639 ! polyketide biosynthetic process relationship: positively_regulates GO:0030639 ! polyketide biosynthetic process created_by: di creation_date: 2012-05-26T01:30:10Z [Term] id: GO:1900735 name: positive regulation of flocculation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flocculation." [GOC:di, GOC:TermGenie] synonym: "activation of flocculation" NARROW [GOC:TermGenie] synonym: "up regulation of flocculation" EXACT [GOC:TermGenie] synonym: "up-regulation of flocculation" EXACT [GOC:TermGenie] synonym: "upregulation of flocculation" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0060256 ! regulation of flocculation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000128 ! flocculation relationship: positively_regulates GO:0000128 ! flocculation created_by: di creation_date: 2012-05-27T08:27:38Z [Term] id: GO:1900736 name: regulation of phospholipase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] synonym: "regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway relationship: regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway created_by: rl creation_date: 2012-05-28T10:07:27Z [Term] id: GO:1900737 name: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "inhibition of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "negative regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] synonym: "negative regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway relationship: negatively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway created_by: rl creation_date: 2012-05-28T10:07:48Z [Term] id: GO:1900738 name: positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "activation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "positive regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] synonym: "positive regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] synonym: "upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway relationship: positively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway created_by: rl creation_date: 2012-05-28T10:07:56Z [Term] id: GO:1900739 name: regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway relationship: regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway created_by: pr creation_date: 2012-05-28T02:28:18Z [Term] id: GO:1900740 name: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "activation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "activation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] is_a: GO:1900739 ! regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway is_a: GO:1901030 ! positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway relationship: positively_regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway created_by: pr creation_date: 2012-05-28T02:28:40Z [Term] id: GO:1900741 name: regulation of filamentous growth of a population of unicellular organisms in response to pH namespace: biological_process def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH relationship: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH created_by: di creation_date: 2012-05-28T02:34:39Z [Term] id: GO:1900742 name: negative regulation of filamentous growth of a population of unicellular organisms in response to pH namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH relationship: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH created_by: di creation_date: 2012-05-28T02:35:03Z [Term] id: GO:1900743 name: positive regulation of filamentous growth of a population of unicellular organisms in response to pH namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] synonym: "activation of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie] synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH relationship: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH created_by: di creation_date: 2012-05-28T02:35:11Z [Term] id: GO:1900744 name: regulation of p38MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie] synonym: "regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038066 ! p38MAPK cascade relationship: regulates GO:0038066 ! p38MAPK cascade created_by: pm creation_date: 2012-05-28T02:40:14Z [Term] id: GO:1900745 name: positive regulation of p38MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie] synonym: "activation of p38 cascade" EXACT [GOC:TermGenie] synonym: "activation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "activation of p38MAPK cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "positive regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "up regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "up regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "up regulation of p38MAPK cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of p38MAPK cascade" EXACT [GOC:TermGenie] synonym: "upregulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "upregulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "upregulation of p38MAPK cascade" EXACT [GOC:TermGenie] is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade is_a: GO:1900744 ! regulation of p38MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038066 ! p38MAPK cascade relationship: positively_regulates GO:0038066 ! p38MAPK cascade created_by: pm creation_date: 2012-05-28T02:40:48Z [Term] id: GO:1900746 name: regulation of vascular endothelial growth factor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] synonym: "regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway relationship: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway created_by: pm creation_date: 2012-05-29T08:28:06Z [Term] id: GO:1900747 name: negative regulation of vascular endothelial growth factor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] synonym: "down regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "down regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "downregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of VEGF signaling" EXACT [GOC:TermGenie] synonym: "inhibition of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway relationship: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway created_by: pm creation_date: 2012-05-29T08:28:29Z [Term] id: GO:1900748 name: positive regulation of vascular endothelial growth factor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] synonym: "activation of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "activation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "activation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "up regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of VEGF signaling" EXACT [GOC:TermGenie] synonym: "upregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway relationship: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway created_by: pm creation_date: 2012-05-29T08:28:36Z [Term] id: GO:1900749 name: (R)-carnitine transport namespace: biological_process def: "The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798] synonym: "(-)-Carnitine transport" RELATED [GOC:TermGenie] synonym: "(-)-L-Carnitine transport" RELATED [GOC:TermGenie] synonym: "(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport" EXACT [GOC:TermGenie] synonym: "(R)-Carnitine transport" EXACT [GOC:TermGenie] synonym: "C7H15NO3 transport" RELATED [GOC:TermGenie] synonym: "Carnicor transport" RELATED [GOC:TermGenie] synonym: "Carnitene transport" RELATED [GOC:TermGenie] synonym: "Carnitine transport" RELATED [GOC:TermGenie] synonym: "Carnitor transport" RELATED [GOC:TermGenie] synonym: "L-Carnitine transport" EXACT [GOC:TermGenie] synonym: "Levocarnitine transport" RELATED [GOC:TermGenie] synonym: "Vitamin BT transport" RELATED [GOC:TermGenie] is_a: GO:0015879 ! carnitine transport is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport created_by: jl creation_date: 2012-05-29T02:01:17Z [Term] id: GO:1900750 name: oligopeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an oligopeptide." [GOC:TermGenie, PMID:21854595] synonym: "Oligopeptid binding" RELATED [GOC:TermGenie] synonym: "oligopeptides binding" EXACT [GOC:TermGenie] synonym: "oligopeptido binding" RELATED [GOC:TermGenie] is_a: GO:0042277 ! peptide binding created_by: jl creation_date: 2012-05-29T02:13:31Z [Term] id: GO:1900751 name: 4-(trimethylammonio)butanoate transport namespace: biological_process def: "The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798] synonym: "4-(N-trimethylamino)butyrate transport" EXACT [GOC:TermGenie] synonym: "4-butyrobetaine transport" EXACT [GOC:TermGenie] synonym: "Actinine transport" RELATED [GOC:TermGenie] synonym: "butyrobetaine transport" RELATED [GOC:TermGenie] synonym: "C7H15NO2 transport" RELATED [GOC:TermGenie] synonym: "deoxycarnitine transport" RELATED [GOC:TermGenie] synonym: "gamma-Butyrobetain transport" EXACT [GOC:TermGenie] synonym: "gamma-butyrobetaine transport" EXACT [GOC:TermGenie] is_a: GO:0015838 ! amino-acid betaine transport created_by: jl creation_date: 2012-05-29T02:32:37Z [Term] id: GO:1900752 name: malonic acid transport namespace: biological_process def: "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9128730, PMID:9573154] synonym: "C3H4O4 transport" RELATED [GOC:TermGenie] synonym: "H2malo transport" RELATED [GOC:TermGenie] synonym: "HOOC-CH2-COOH transport" RELATED [GOC:TermGenie] synonym: "propanedioic acid transport" EXACT [GOC:TermGenie] is_a: GO:0006835 ! dicarboxylic acid transport created_by: jl creation_date: 2012-05-29T02:40:33Z [Term] id: GO:1900753 name: doxorubicin transport namespace: biological_process def: "The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:12057006, PMID:15090538, PMID:19063901, PMID:19651502, PMID:9651400] synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" EXACT [GOC:TermGenie] synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" RELATED [GOC:TermGenie] synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport" RELATED [GOC:TermGenie] synonym: "14-hydroxydaunomycin transport" RELATED [GOC:TermGenie] synonym: "14-hydroxydaunorubicine transport" RELATED [GOC:TermGenie] synonym: "Adriamycin transport" RELATED [GOC:TermGenie] synonym: "doxorubicine transport" RELATED [GOC:TermGenie] synonym: "doxorubicinum transport" RELATED [GOC:TermGenie] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:1901656 ! glycoside transport created_by: jl creation_date: 2012-05-29T02:50:43Z [Term] id: GO:1900754 name: 4-hydroxyphenylacetate transport namespace: biological_process def: "The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9315705] synonym: "(4-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie] synonym: "(p-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie] synonym: "2-(4-hydroxyphenyl)ethanoate transport" EXACT [GOC:TermGenie] synonym: "4-hydroxybenzeneacetate transport" EXACT [GOC:TermGenie] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport created_by: jl creation_date: 2012-05-29T02:59:02Z [Term] id: GO:1900756 name: protein processing in phagocytic vesicle namespace: biological_process def: "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie] synonym: "peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "protein processing in phagosome" EXACT [GOC:TermGenie] is_a: GO:0016485 ! protein processing intersection_of: GO:0016485 ! protein processing intersection_of: occurs_in GO:0045335 ! phagocytic vesicle relationship: occurs_in GO:0045335 ! phagocytic vesicle created_by: rjd creation_date: 2012-05-29T09:55:14Z [Term] id: GO:1900757 name: regulation of D-amino-acid oxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] synonym: "regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of new yellow enzyme" RELATED [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003884 ! D-amino-acid oxidase activity relationship: regulates GO:0003884 ! D-amino-acid oxidase activity created_by: pm creation_date: 2012-05-31T11:23:45Z [Term] id: GO:1900758 name: negative regulation of D-amino-acid oxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] synonym: "down regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "down regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "down-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "down-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "downregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "downregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "inhibition of D-amino-acid oxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "inhibition of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "inhibition of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "negative regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of new yellow enzyme" RELATED [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003884 ! D-amino-acid oxidase activity relationship: negatively_regulates GO:0003884 ! D-amino-acid oxidase activity created_by: pm creation_date: 2012-05-31T11:24:06Z [Term] id: GO:1900759 name: positive regulation of D-amino-acid oxidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] synonym: "activation of D-amino-acid oxidase activity" NARROW [GOC:TermGenie] synonym: "activation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "activation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "activation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "positive regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "up regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "up regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "up-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "up-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of new yellow enzyme" RELATED [GOC:TermGenie] synonym: "upregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] synonym: "upregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of new yellow enzyme" RELATED [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003884 ! D-amino-acid oxidase activity relationship: positively_regulates GO:0003884 ! D-amino-acid oxidase activity created_by: pm creation_date: 2012-05-31T11:24:14Z [Term] id: GO:1900760 name: negative regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] synonym: "down regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of sterigmatocystin formation" EXACT [GOC:TermGenie] synonym: "downregulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of sterigmatocystin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of sterigmatocystin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of sterigmatocystin formation" EXACT [GOC:TermGenie] synonym: "inhibition of sterigmatocystin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process relationship: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process created_by: di creation_date: 2012-06-04T08:38:30Z [Term] id: GO:1900761 name: averantin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving averantin." [GOC:di, GOC:TermGenie] synonym: "averantin metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: di creation_date: 2012-06-04T09:14:22Z [Term] id: GO:1900762 name: averantin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of averantin." [GOC:di, GOC:TermGenie] synonym: "averantin breakdown" EXACT [GOC:TermGenie] synonym: "averantin catabolism" EXACT [GOC:TermGenie] synonym: "averantin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:1900761 ! averantin metabolic process is_a: GO:1901662 ! quinone catabolic process created_by: di creation_date: 2012-06-04T09:14:45Z [Term] id: GO:1900763 name: averantin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of averantin." [GOC:di, GOC:TermGenie] synonym: "averantin anabolism" EXACT [GOC:TermGenie] synonym: "averantin biosynthesis" EXACT [GOC:TermGenie] synonym: "averantin formation" EXACT [GOC:TermGenie] synonym: "averantin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900761 ! averantin metabolic process is_a: GO:1901663 ! quinone biosynthetic process created_by: di creation_date: 2012-06-04T09:14:52Z [Term] id: GO:1900764 name: emericellin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving emericellin." [GOC:di, GOC:TermGenie] synonym: "emericellin metabolism" EXACT [GOC:TermGenie] synonym: "Variecoxanthone B metabolic process" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B metabolism" RELATED [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:2001305 ! xanthone-containing compound metabolic process created_by: di creation_date: 2012-06-04T09:17:58Z [Term] id: GO:1900765 name: emericellin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of emericellin." [GOC:di, GOC:TermGenie] synonym: "emericellin breakdown" EXACT [GOC:TermGenie] synonym: "emericellin catabolism" EXACT [GOC:TermGenie] synonym: "emericellin degradation" EXACT [GOC:TermGenie] synonym: "Variecoxanthone B breakdown" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B catabolic process" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B catabolism" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B degradation" RELATED [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900764 ! emericellin metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-06-04T09:18:22Z [Term] id: GO:1900766 name: emericellin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of emericellin." [GOC:di, GOC:TermGenie] synonym: "emericellin anabolism" EXACT [GOC:TermGenie] synonym: "emericellin biosynthesis" EXACT [GOC:TermGenie] synonym: "emericellin formation" EXACT [GOC:TermGenie] synonym: "emericellin synthesis" EXACT [GOC:TermGenie] synonym: "Variecoxanthone B anabolism" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B formation" RELATED [GOC:TermGenie] synonym: "Variecoxanthone B synthesis" RELATED [GOC:TermGenie] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900764 ! emericellin metabolic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:2001307 ! xanthone-containing compound biosynthetic process created_by: di creation_date: 2012-06-04T09:18:29Z [Term] id: GO:1900767 name: fonsecin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fonsecin." [GOC:di, GOC:TermGenie] synonym: "fonsecin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process created_by: di creation_date: 2012-06-04T09:21:14Z [Term] id: GO:1900768 name: fonsecin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fonsecin." [GOC:di, GOC:TermGenie] synonym: "fonsecin breakdown" EXACT [GOC:TermGenie] synonym: "fonsecin catabolism" EXACT [GOC:TermGenie] synonym: "fonsecin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1900767 ! fonsecin metabolic process is_a: GO:1900786 ! naphtho-gamma-pyrone catabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-06-04T09:21:38Z [Term] id: GO:1900769 name: fonsecin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fonsecin." [GOC:di, GOC:TermGenie] synonym: "fonsecin anabolism" EXACT [GOC:TermGenie] synonym: "fonsecin biosynthesis" EXACT [GOC:TermGenie] synonym: "fonsecin formation" EXACT [GOC:TermGenie] synonym: "fonsecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900767 ! fonsecin metabolic process is_a: GO:1900787 ! naphtho-gamma-pyrone biosynthetic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-06-04T09:21:49Z [Term] id: GO:1900770 name: fumitremorgin B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumitremorgin B." [GOC:di, GOC:TermGenie] synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie] synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie] synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie] is_a: GO:0035834 ! indole alkaloid metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: di creation_date: 2012-06-04T09:25:18Z [Term] id: GO:1900771 name: fumitremorgin B catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumitremorgin B." [GOC:di, GOC:TermGenie] synonym: "fumitremorgin B breakdown" EXACT [GOC:TermGenie] synonym: "fumitremorgin B catabolism" EXACT [GOC:TermGenie] synonym: "fumitremorgin B degradation" EXACT [GOC:TermGenie] synonym: "Lanosulin breakdown" RELATED [GOC:TermGenie] synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie] synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie] synonym: "Lanosulin degradation" RELATED [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900770 ! fumitremorgin B metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process created_by: di creation_date: 2012-06-04T09:25:43Z [Term] id: GO:1900772 name: fumitremorgin B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumitremorgin B." [GOC:di, GOC:TermGenie] synonym: "fumitremorgin B anabolism" EXACT [GOC:TermGenie] synonym: "fumitremorgin B biosynthesis" EXACT [GOC:TermGenie] synonym: "fumitremorgin B formation" EXACT [GOC:TermGenie] synonym: "fumitremorgin B synthesis" EXACT [GOC:TermGenie] synonym: "Lanosulin anabolism" RELATED [GOC:TermGenie] synonym: "Lanosulin biosynthesis" RELATED [GOC:TermGenie] synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie] synonym: "Lanosulin formation" RELATED [GOC:TermGenie] synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie] is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:1900770 ! fumitremorgin B metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process created_by: di creation_date: 2012-06-04T09:25:50Z [Term] id: GO:1900773 name: fumiquinazoline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumiquinazoline." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline metabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazolines metabolic process" RELATED [GOC:TermGenie] synonym: "fumiquinazolines metabolism" RELATED [GOC:TermGenie] is_a: GO:0035834 ! indole alkaloid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-06-04T09:29:22Z [Term] id: GO:1900774 name: fumiquinazoline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline breakdown" EXACT [GOC:TermGenie] synonym: "fumiquinazoline catabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline degradation" EXACT [GOC:TermGenie] synonym: "fumiquinazolines breakdown" RELATED [GOC:TermGenie] synonym: "fumiquinazolines catabolic process" RELATED [GOC:TermGenie] synonym: "fumiquinazolines catabolism" RELATED [GOC:TermGenie] synonym: "fumiquinazolines degradation" RELATED [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900773 ! fumiquinazoline metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-06-04T09:29:46Z [Term] id: GO:1900775 name: fumiquinazoline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline anabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline biosynthesis" EXACT [GOC:TermGenie] synonym: "fumiquinazoline formation" EXACT [GOC:TermGenie] synonym: "fumiquinazoline synthesis" EXACT [GOC:TermGenie] synonym: "fumiquinazolines anabolism" RELATED [GOC:TermGenie] synonym: "fumiquinazolines biosynthesis" RELATED [GOC:TermGenie] synonym: "fumiquinazolines biosynthetic process" RELATED [GOC:TermGenie] synonym: "fumiquinazolines formation" RELATED [GOC:TermGenie] synonym: "fumiquinazolines synthesis" RELATED [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:1900773 ! fumiquinazoline metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-06-04T09:29:54Z [Term] id: GO:1900776 name: fumiquinazoline A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumiquinazoline A." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline A metabolism" EXACT [GOC:TermGenie] is_a: GO:1900773 ! fumiquinazoline metabolic process created_by: di creation_date: 2012-06-04T09:29:58Z [Term] id: GO:1900777 name: fumiquinazoline A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline A breakdown" EXACT [GOC:TermGenie] synonym: "fumiquinazoline A catabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline A degradation" EXACT [GOC:TermGenie] is_a: GO:1900774 ! fumiquinazoline catabolic process is_a: GO:1900776 ! fumiquinazoline A metabolic process created_by: di creation_date: 2012-06-04T09:30:18Z [Term] id: GO:1900778 name: fumiquinazoline A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline A." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline A anabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline A biosynthesis" EXACT [GOC:TermGenie] synonym: "fumiquinazoline A formation" EXACT [GOC:TermGenie] synonym: "fumiquinazoline A synthesis" EXACT [GOC:TermGenie] is_a: GO:1900775 ! fumiquinazoline biosynthetic process is_a: GO:1900776 ! fumiquinazoline A metabolic process created_by: di creation_date: 2012-06-04T09:30:25Z [Term] id: GO:1900779 name: fumiquinazoline C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumiquinazoline C." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline C metabolism" EXACT [GOC:TermGenie] is_a: GO:1900773 ! fumiquinazoline metabolic process created_by: di creation_date: 2012-06-04T09:30:30Z [Term] id: GO:1900780 name: fumiquinazoline C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline C breakdown" EXACT [GOC:TermGenie] synonym: "fumiquinazoline C catabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline C degradation" EXACT [GOC:TermGenie] is_a: GO:1900774 ! fumiquinazoline catabolic process is_a: GO:1900779 ! fumiquinazoline C metabolic process created_by: di creation_date: 2012-06-04T09:30:51Z [Term] id: GO:1900781 name: fumiquinazoline C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline C." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline C anabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline C biosynthesis" EXACT [GOC:TermGenie] synonym: "fumiquinazoline C formation" EXACT [GOC:TermGenie] synonym: "fumiquinazoline C synthesis" EXACT [GOC:TermGenie] is_a: GO:1900775 ! fumiquinazoline biosynthetic process is_a: GO:1900779 ! fumiquinazoline C metabolic process created_by: di creation_date: 2012-06-04T09:30:58Z [Term] id: GO:1900782 name: fumiquinazoline F metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumiquinazoline F." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline F metabolism" EXACT [GOC:TermGenie] is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:1900773 ! fumiquinazoline metabolic process created_by: di creation_date: 2012-06-04T09:31:06Z [Term] id: GO:1900783 name: fumiquinazoline F catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline F breakdown" EXACT [GOC:TermGenie] synonym: "fumiquinazoline F catabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline F degradation" EXACT [GOC:TermGenie] is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1900774 ! fumiquinazoline catabolic process is_a: GO:1900782 ! fumiquinazoline F metabolic process created_by: di creation_date: 2012-06-04T09:31:27Z [Term] id: GO:1900784 name: fumiquinazoline F biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline F." [GOC:di, GOC:TermGenie] synonym: "fumiquinazoline F anabolism" EXACT [GOC:TermGenie] synonym: "fumiquinazoline F biosynthesis" EXACT [GOC:TermGenie] synonym: "fumiquinazoline F formation" EXACT [GOC:TermGenie] synonym: "fumiquinazoline F synthesis" EXACT [GOC:TermGenie] is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:1900775 ! fumiquinazoline biosynthetic process is_a: GO:1900782 ! fumiquinazoline F metabolic process created_by: di creation_date: 2012-06-04T09:31:34Z [Term] id: GO:1900785 name: naphtho-gamma-pyrone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] synonym: "naphtho-gamma-pyrone metabolism" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrones metabolic process" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones metabolism" RELATED [GOC:TermGenie] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-06-04T09:35:32Z [Term] id: GO:1900786 name: naphtho-gamma-pyrone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] synonym: "naphtho-gamma-pyrone breakdown" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrone catabolism" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrone degradation" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrones breakdown" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones catabolic process" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones catabolism" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones degradation" RELATED [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-06-04T09:35:54Z [Term] id: GO:1900787 name: naphtho-gamma-pyrone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] synonym: "naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie] synonym: "naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie] synonym: "naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-06-04T09:36:02Z [Term] id: GO:1900788 name: pseurotin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pseurotin A." [GOC:di, GOC:TermGenie] synonym: "pseurotin A metabolism" EXACT [GOC:TermGenie] synonym: "Pseurotin metabolic process" RELATED [GOC:TermGenie] synonym: "Pseurotin metabolism" RELATED [GOC:TermGenie] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: di creation_date: 2012-06-04T09:37:18Z [Term] id: GO:1900789 name: pseurotin A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pseurotin A." [GOC:di, GOC:TermGenie] synonym: "pseurotin A breakdown" EXACT [GOC:TermGenie] synonym: "pseurotin A catabolism" EXACT [GOC:TermGenie] synonym: "pseurotin A degradation" EXACT [GOC:TermGenie] synonym: "Pseurotin breakdown" RELATED [GOC:TermGenie] synonym: "Pseurotin catabolic process" RELATED [GOC:TermGenie] synonym: "Pseurotin catabolism" RELATED [GOC:TermGenie] synonym: "Pseurotin degradation" RELATED [GOC:TermGenie] is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900788 ! pseurotin A metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: di creation_date: 2012-06-04T09:37:41Z [Term] id: GO:1900790 name: pseurotin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pseurotin A." [GOC:di, GOC:TermGenie] synonym: "pseurotin A anabolism" EXACT [GOC:TermGenie] synonym: "pseurotin A biosynthesis" EXACT [GOC:TermGenie] synonym: "pseurotin A formation" EXACT [GOC:TermGenie] synonym: "pseurotin A synthesis" EXACT [GOC:TermGenie] synonym: "Pseurotin anabolism" RELATED [GOC:TermGenie] synonym: "Pseurotin biosynthesis" RELATED [GOC:TermGenie] synonym: "Pseurotin biosynthetic process" RELATED [GOC:TermGenie] synonym: "Pseurotin formation" RELATED [GOC:TermGenie] synonym: "Pseurotin synthesis" RELATED [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1900788 ! pseurotin A metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: di creation_date: 2012-06-04T09:37:49Z [Term] id: GO:1900791 name: shamixanthone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving shamixanthone." [GOC:di, GOC:TermGenie] synonym: "shamixanthone metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: di creation_date: 2012-06-04T09:40:20Z [Term] id: GO:1900792 name: shamixanthone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of shamixanthone." [GOC:di, GOC:TermGenie] synonym: "shamixanthone breakdown" EXACT [GOC:TermGenie] synonym: "shamixanthone catabolism" EXACT [GOC:TermGenie] synonym: "shamixanthone degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900791 ! shamixanthone metabolic process created_by: di creation_date: 2012-06-04T09:40:42Z [Term] id: GO:1900793 name: shamixanthone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of shamixanthone." [GOC:di, GOC:TermGenie] synonym: "shamixanthone anabolism" EXACT [GOC:TermGenie] synonym: "shamixanthone biosynthesis" EXACT [GOC:TermGenie] synonym: "shamixanthone formation" EXACT [GOC:TermGenie] synonym: "shamixanthone synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900791 ! shamixanthone metabolic process created_by: di creation_date: 2012-06-04T09:40:49Z [Term] id: GO:1900794 name: terrequinone A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terrequinone A." [GOC:di, GOC:TermGenie] synonym: "terrequinone A metabolism" EXACT [GOC:TermGenie] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: di creation_date: 2012-06-04T09:45:20Z [Term] id: GO:1900795 name: terrequinone A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terrequinone A." [GOC:di, GOC:TermGenie] synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie] synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie] synonym: "terrequinone A degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900794 ! terrequinone A metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1901662 ! quinone catabolic process created_by: di creation_date: 2012-06-04T09:45:41Z [Term] id: GO:1900796 name: terrequinone A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terrequinone A." [GOC:di, GOC:TermGenie] synonym: "terrequinone A anabolism" EXACT [GOC:TermGenie] synonym: "terrequinone A biosynthesis" EXACT [GOC:TermGenie] synonym: "terrequinone A formation" EXACT [GOC:TermGenie] synonym: "terrequinone A synthesis" EXACT [GOC:TermGenie] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900794 ! terrequinone A metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process created_by: di creation_date: 2012-06-04T09:45:48Z [Term] id: GO:1900797 name: cordyol C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie] synonym: "cordyol C metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0019748 ! secondary metabolic process created_by: di creation_date: 2012-06-04T09:47:48Z [Term] id: GO:1900798 name: cordyol C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cordyol C." [GOC:di, GOC:TermGenie] synonym: "cordyol C breakdown" EXACT [GOC:TermGenie] synonym: "cordyol C catabolism" EXACT [GOC:TermGenie] synonym: "cordyol C degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900797 ! cordyol C metabolic process is_a: GO:1901502 ! ether catabolic process created_by: di creation_date: 2012-06-04T09:48:10Z [Term] id: GO:1900799 name: cordyol C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cordyol C." [GOC:di, GOC:TermGenie] synonym: "cordyol C anabolism" EXACT [GOC:TermGenie] synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie] synonym: "cordyol C formation" EXACT [GOC:TermGenie] synonym: "cordyol C synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900797 ! cordyol C metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di creation_date: 2012-06-04T09:48:17Z [Term] id: GO:1900800 name: cspyrone B1 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cspyrone B1." [GOC:di, GOC:TermGenie] synonym: "cspyrone B1 metabolism" EXACT [GOC:TermGenie] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: di creation_date: 2012-06-04T09:50:37Z [Term] id: GO:1900801 name: cspyrone B1 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cspyrone B1." [GOC:di, GOC:TermGenie] synonym: "cspyrone B1 breakdown" EXACT [GOC:TermGenie] synonym: "cspyrone B1 catabolism" EXACT [GOC:TermGenie] synonym: "cspyrone B1 degradation" EXACT [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900800 ! cspyrone B1 metabolic process is_a: GO:1901335 ! lactone catabolic process created_by: di creation_date: 2012-06-04T09:50:58Z [Term] id: GO:1900802 name: cspyrone B1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cspyrone B1." [GOC:di, GOC:TermGenie] synonym: "cspyrone B1 anabolism" EXACT [GOC:TermGenie] synonym: "cspyrone B1 biosynthesis" EXACT [GOC:TermGenie] synonym: "cspyrone B1 formation" EXACT [GOC:TermGenie] synonym: "cspyrone B1 synthesis" EXACT [GOC:TermGenie] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900800 ! cspyrone B1 metabolic process is_a: GO:1901336 ! lactone biosynthetic process created_by: di creation_date: 2012-06-04T09:51:06Z [Term] id: GO:1900803 name: brevianamide F metabolic process namespace: biological_process def: "The chemical reactions and pathways involving brevianamide F." [GOC:di, GOC:TermGenie] synonym: "brevianamide F metabolism" EXACT [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) metabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro metabolic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro metabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline metabolic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline metabolism" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride metabolic process" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride metabolism" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride metabolic process" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride metabolism" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine metabolic process" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine metabolism" RELATED [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process created_by: di creation_date: 2012-06-04T09:52:19Z [Term] id: GO:1900804 name: brevianamide F catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of brevianamide F." [GOC:di, GOC:TermGenie] synonym: "brevianamide F breakdown" EXACT [GOC:TermGenie] synonym: "brevianamide F catabolism" EXACT [GOC:TermGenie] synonym: "brevianamide F degradation" EXACT [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) breakdown" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) catabolic process" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) catabolism" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) degradation" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro breakdown" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro catabolic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro catabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro degradation" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline breakdown" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline catabolic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline catabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline degradation" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride breakdown" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride catabolic process" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride catabolism" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride degradation" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride breakdown" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride catabolic process" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride catabolism" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride degradation" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine breakdown" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine catabolic process" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine catabolism" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine degradation" RELATED [GOC:TermGenie] is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900803 ! brevianamide F metabolic process created_by: di creation_date: 2012-06-04T09:52:41Z [Term] id: GO:1900805 name: brevianamide F biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of brevianamide F." [GOC:di, GOC:TermGenie] synonym: "brevianamide F anabolism" EXACT [GOC:TermGenie] synonym: "brevianamide F biosynthesis" EXACT [GOC:TermGenie] synonym: "brevianamide F formation" EXACT [GOC:TermGenie] synonym: "brevianamide F synthesis" EXACT [GOC:TermGenie] synonym: "C16H17N3O2 anabolism" RELATED [GOC:TermGenie] synonym: "C16H17N3O2 biosynthesis" RELATED [GOC:TermGenie] synonym: "C16H17N3O2 biosynthetic process" RELATED [GOC:TermGenie] synonym: "C16H17N3O2 formation" RELATED [GOC:TermGenie] synonym: "C16H17N3O2 synthesis" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) anabolism" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) biosynthesis" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) biosynthetic process" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) formation" RELATED [GOC:TermGenie] synonym: "cyclo-(Trp-Pro) synthesis" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro anabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro biosynthesis" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro biosynthetic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro formation" RELATED [GOC:TermGenie] synonym: "cyclo-L-Trp-L-Pro synthesis" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline anabolism" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline biosynthesis" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline biosynthetic process" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline formation" RELATED [GOC:TermGenie] synonym: "cyclo-L-tryptophanyl-L-proline synthesis" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride anabolism" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride biosynthesis" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride biosynthetic process" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride formation" RELATED [GOC:TermGenie] synonym: "L-prolyl-L-tryptophan anhydride synthesis" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride anabolism" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthesis" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthetic process" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride formation" RELATED [GOC:TermGenie] synonym: "L-tryptophyl-L-proline cyclic anhydride synthesis" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine anabolism" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine biosynthesis" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine formation" RELATED [GOC:TermGenie] synonym: "tryptophan-proline diketopiperazine synthesis" RELATED [GOC:TermGenie] is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900803 ! brevianamide F metabolic process created_by: di creation_date: 2012-06-04T09:52:48Z [Term] id: GO:1900806 name: ergot alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ergot alkaloid." [GOC:di, GOC:TermGenie] synonym: "ergot alkaloid breakdown" EXACT [GOC:TermGenie] synonym: "ergot alkaloid catabolism" EXACT [GOC:TermGenie] synonym: "ergot alkaloid degradation" EXACT [GOC:TermGenie] synonym: "ergot alkaloids breakdown" RELATED [GOC:TermGenie] synonym: "ergot alkaloids catabolic process" RELATED [GOC:TermGenie] synonym: "ergot alkaloids catabolism" RELATED [GOC:TermGenie] synonym: "ergot alkaloids degradation" RELATED [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0035836 ! ergot alkaloid metabolic process is_a: GO:0090487 ! secondary metabolite catabolic process created_by: di creation_date: 2012-06-04T09:57:39Z [Term] id: GO:1900807 name: fumigaclavine C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumigaclavine C." [GOC:di, GOC:TermGenie] synonym: "fumigaclavine C metabolism" EXACT [GOC:TermGenie] is_a: GO:0035836 ! ergot alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1900619 ! acetate ester metabolic process created_by: di creation_date: 2012-06-04T09:59:32Z [Term] id: GO:1900808 name: fumigaclavine C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumigaclavine C." [GOC:di, GOC:TermGenie] synonym: "fumigaclavine C breakdown" EXACT [GOC:TermGenie] synonym: "fumigaclavine C catabolism" EXACT [GOC:TermGenie] synonym: "fumigaclavine C degradation" EXACT [GOC:TermGenie] is_a: GO:1900806 ! ergot alkaloid catabolic process is_a: GO:1900807 ! fumigaclavine C metabolic process created_by: di creation_date: 2012-06-04T09:59:55Z [Term] id: GO:1900809 name: fumigaclavine C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumigaclavine C." [GOC:di, GOC:TermGenie] synonym: "fumigaclavine C anabolism" EXACT [GOC:TermGenie] synonym: "fumigaclavine C biosynthesis" EXACT [GOC:TermGenie] synonym: "fumigaclavine C formation" EXACT [GOC:TermGenie] synonym: "fumigaclavine C synthesis" EXACT [GOC:TermGenie] is_a: GO:0035837 ! ergot alkaloid biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process is_a: GO:1900807 ! fumigaclavine C metabolic process created_by: di creation_date: 2012-06-04T10:00:06Z [Term] id: GO:1900810 name: helvolic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving helvolic acid." [GOC:di, GOC:TermGenie] synonym: "Fumigacin metabolic process" RELATED [GOC:TermGenie] synonym: "Fumigacin metabolism" RELATED [GOC:TermGenie] synonym: "helvolic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process created_by: di creation_date: 2012-06-04T10:02:28Z [Term] id: GO:1900811 name: helvolic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of helvolic acid." [GOC:di, GOC:TermGenie] synonym: "Fumigacin breakdown" RELATED [GOC:TermGenie] synonym: "Fumigacin catabolic process" RELATED [GOC:TermGenie] synonym: "Fumigacin catabolism" RELATED [GOC:TermGenie] synonym: "Fumigacin degradation" RELATED [GOC:TermGenie] synonym: "helvolic acid breakdown" EXACT [GOC:TermGenie] synonym: "helvolic acid catabolism" EXACT [GOC:TermGenie] synonym: "helvolic acid degradation" EXACT [GOC:TermGenie] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900810 ! helvolic acid metabolic process created_by: di creation_date: 2012-06-04T10:02:51Z [Term] id: GO:1900812 name: helvolic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of helvolic acid." [GOC:di, GOC:TermGenie] synonym: "Fumigacin anabolism" RELATED [GOC:TermGenie] synonym: "Fumigacin biosynthesis" RELATED [GOC:TermGenie] synonym: "Fumigacin biosynthetic process" RELATED [GOC:TermGenie] synonym: "Fumigacin formation" RELATED [GOC:TermGenie] synonym: "Fumigacin synthesis" RELATED [GOC:TermGenie] synonym: "helvolic acid anabolism" EXACT [GOC:TermGenie] synonym: "helvolic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "helvolic acid formation" EXACT [GOC:TermGenie] synonym: "helvolic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900810 ! helvolic acid metabolic process created_by: di creation_date: 2012-06-04T10:02:58Z [Term] id: GO:1900813 name: monodictyphenone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monodictyphenone." [GOC:di, GOC:TermGenie] synonym: "monodictyphenone metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: di creation_date: 2012-06-04T10:11:03Z [Term] id: GO:1900814 name: monodictyphenone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monodictyphenone." [GOC:di, GOC:TermGenie] synonym: "monodictyphenone breakdown" EXACT [GOC:TermGenie] synonym: "monodictyphenone catabolism" EXACT [GOC:TermGenie] synonym: "monodictyphenone degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900813 ! monodictyphenone metabolic process created_by: di creation_date: 2012-06-04T10:11:27Z [Term] id: GO:1900815 name: monodictyphenone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monodictyphenone." [GOC:di, GOC:TermGenie] synonym: "monodictyphenone anabolism" EXACT [GOC:TermGenie] synonym: "monodictyphenone biosynthesis" EXACT [GOC:TermGenie] synonym: "monodictyphenone formation" EXACT [GOC:TermGenie] synonym: "monodictyphenone synthesis" EXACT [GOC:TermGenie] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1900813 ! monodictyphenone metabolic process created_by: di creation_date: 2012-06-04T10:11:35Z [Term] id: GO:1900816 name: ochratoxin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC:TermGenie] synonym: "Ochratoxin A metabolic process" EXACT [GOC:TermGenie] synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-06-04T10:13:02Z [Term] id: GO:1900817 name: ochratoxin A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ochratoxin A." [GOC:di, GOC:TermGenie] synonym: "Ochratoxin A breakdown" EXACT [GOC:TermGenie] synonym: "ochratoxin A breakdown" EXACT [GOC:TermGenie] synonym: "Ochratoxin A catabolic process" EXACT [GOC:TermGenie] synonym: "Ochratoxin A catabolism" EXACT [GOC:TermGenie] synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie] synonym: "Ochratoxin A degradation" EXACT [GOC:TermGenie] synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie] is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900816 ! ochratoxin A metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-06-04T10:13:26Z [Term] id: GO:1900818 name: ochratoxin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ochratoxin A." [GOC:di, GOC:TermGenie] synonym: "Ochratoxin A anabolism" EXACT [GOC:TermGenie] synonym: "Ochratoxin A biosynthesis" EXACT [GOC:TermGenie] synonym: "Ochratoxin A biosynthetic process" EXACT [GOC:TermGenie] synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie] synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900816 ! ochratoxin A metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-06-04T10:13:32Z [Term] id: GO:1900819 name: orlandin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving orlandin." [GOC:di, GOC:TermGenie] synonym: "orlandin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2012-06-04T10:14:55Z [Term] id: GO:1900820 name: orlandin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of orlandin." [GOC:di, GOC:TermGenie] synonym: "orlandin breakdown" EXACT [GOC:TermGenie] synonym: "orlandin catabolism" EXACT [GOC:TermGenie] synonym: "orlandin degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900819 ! orlandin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: di creation_date: 2012-06-04T10:15:17Z [Term] id: GO:1900821 name: orlandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of orlandin." [GOC:di, GOC:TermGenie] synonym: "orlandin anabolism" EXACT [GOC:TermGenie] synonym: "orlandin biosynthesis" EXACT [GOC:TermGenie] synonym: "orlandin formation" EXACT [GOC:TermGenie] synonym: "orlandin synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900819 ! orlandin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: di creation_date: 2012-06-04T10:15:24Z [Term] id: GO:1900822 name: regulation of ergot alkaloid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035837 ! ergot alkaloid biosynthetic process relationship: regulates GO:0035837 ! ergot alkaloid biosynthetic process created_by: di creation_date: 2012-06-04T11:12:32Z [Term] id: GO:1900823 name: negative regulation of ergot alkaloid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "down regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "downregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "inhibition of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process relationship: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process created_by: di creation_date: 2012-06-04T11:12:54Z [Term] id: GO:1900824 name: positive regulation of ergot alkaloid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "activation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "activation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "up regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of ergot alkaloid formation" EXACT [GOC:TermGenie] synonym: "upregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process relationship: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process created_by: di creation_date: 2012-06-04T11:13:05Z [Term] id: GO:1900825 name: regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:0098902 ! regulation of membrane depolarization during action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential relationship: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential created_by: rl creation_date: 2012-06-06T04:15:20Z [Term] id: GO:1900826 name: negative regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] synonym: "down regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during of cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential relationship: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential created_by: rl creation_date: 2012-06-06T04:15:40Z [Term] id: GO:1900827 name: positive regulation of membrane depolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] synonym: "activation of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential relationship: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential created_by: rl creation_date: 2012-06-06T04:15:48Z [Term] id: GO:1900828 name: D-tyrosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-tyrosine." [GOC:TermGenie, PMID:10766779] synonym: "D-tyrosine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0046416 ! D-amino acid metabolic process created_by: se creation_date: 2012-06-06T09:27:00Z [Term] id: GO:1900829 name: D-tyrosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-tyrosine." [GOC:TermGenie, PMID:10766779] synonym: "D-tyrosine breakdown" EXACT [GOC:TermGenie] synonym: "D-tyrosine catabolism" EXACT [GOC:TermGenie] synonym: "D-tyrosine degradation" EXACT [GOC:TermGenie] is_a: GO:0006572 ! tyrosine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:1900828 ! D-tyrosine metabolic process created_by: se creation_date: 2012-06-06T09:27:24Z [Term] id: GO:1900830 name: D-tyrosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-tyrosine." [GOC:TermGenie, PMID:10766779] synonym: "D-tyrosine anabolism" EXACT [GOC:TermGenie] synonym: "D-tyrosine biosynthesis" EXACT [GOC:TermGenie] synonym: "D-tyrosine formation" EXACT [GOC:TermGenie] synonym: "D-tyrosine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0046437 ! D-amino acid biosynthetic process is_a: GO:1900828 ! D-tyrosine metabolic process created_by: se creation_date: 2012-06-06T09:27:31Z [Term] id: GO:1900831 name: D-leucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-leucine." [GOC:TermGenie, PMID:10918062] synonym: "D-leucine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006551 ! leucine metabolic process is_a: GO:0046416 ! D-amino acid metabolic process created_by: se creation_date: 2012-06-06T09:37:17Z [Term] id: GO:1900832 name: D-leucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-leucine." [GOC:TermGenie, PMID:10918062] synonym: "D-leucine breakdown" EXACT [GOC:TermGenie] synonym: "D-leucine catabolism" EXACT [GOC:TermGenie] synonym: "D-leucine degradation" EXACT [GOC:TermGenie] is_a: GO:0006552 ! leucine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:1900831 ! D-leucine metabolic process created_by: se creation_date: 2012-06-06T09:37:40Z [Term] id: GO:1900833 name: D-leucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-leucine." [GOC:TermGenie, PMID:10918062] synonym: "D-leucine anabolism" EXACT [GOC:TermGenie] synonym: "D-leucine biosynthesis" EXACT [GOC:TermGenie] synonym: "D-leucine formation" EXACT [GOC:TermGenie] synonym: "D-leucine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009098 ! leucine biosynthetic process is_a: GO:0046437 ! D-amino acid biosynthetic process is_a: GO:1900831 ! D-leucine metabolic process created_by: se creation_date: 2012-06-06T09:37:47Z [Term] id: GO:1900834 name: regulation of emericellin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of emericellin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of emericellin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of emericellin formation" EXACT [GOC:TermGenie] synonym: "regulation of emericellin synthesis" EXACT [GOC:TermGenie] synonym: "regulation of Variecoxanthone B anabolism" RELATED [GOC:TermGenie] synonym: "regulation of Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of Variecoxanthone B formation" RELATED [GOC:TermGenie] synonym: "regulation of Variecoxanthone B synthesis" RELATED [GOC:TermGenie] is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900766 ! emericellin biosynthetic process relationship: regulates GO:1900766 ! emericellin biosynthetic process created_by: di creation_date: 2012-06-07T09:32:02Z [Term] id: GO:1900835 name: negative regulation of emericellin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:1900184 ! negative regulation of xanthone-containing compound biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900834 ! regulation of emericellin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900766 ! emericellin biosynthetic process relationship: negatively_regulates GO:1900766 ! emericellin biosynthetic process created_by: di creation_date: 2012-06-07T09:32:24Z [Term] id: GO:1900836 name: positive regulation of emericellin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] is_a: GO:1900185 ! positive regulation of xanthone-containing compound biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900834 ! regulation of emericellin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900766 ! emericellin biosynthetic process relationship: positively_regulates GO:1900766 ! emericellin biosynthetic process created_by: di creation_date: 2012-06-07T09:32:31Z [Term] id: GO:1900837 name: regulation of fumigaclavine C biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of fumigaclavine C anabolism" EXACT [GOC:TermGenie] synonym: "regulation of fumigaclavine C biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of fumigaclavine C formation" EXACT [GOC:TermGenie] synonym: "regulation of fumigaclavine C synthesis" EXACT [GOC:TermGenie] is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900809 ! fumigaclavine C biosynthetic process relationship: regulates GO:1900809 ! fumigaclavine C biosynthetic process created_by: di creation_date: 2012-06-07T09:36:22Z [Term] id: GO:1900838 name: negative regulation of fumigaclavine C biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "inhibition of fumigaclavine C biosynthetic process" NARROW [GOC:TermGenie] is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process relationship: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process created_by: di creation_date: 2012-06-07T09:36:45Z [Term] id: GO:1900839 name: positive regulation of fumigaclavine C biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process relationship: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process created_by: di creation_date: 2012-06-07T09:36:52Z [Term] id: GO:1900840 name: regulation of helvolic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900812 ! helvolic acid biosynthetic process relationship: regulates GO:1900812 ! helvolic acid biosynthetic process created_by: di creation_date: 2012-06-07T09:38:33Z [Term] id: GO:1900841 name: negative regulation of helvolic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process relationship: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process created_by: di creation_date: 2012-06-07T09:38:57Z [Term] id: GO:1900842 name: positive regulation of helvolic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900812 ! helvolic acid biosynthetic process relationship: positively_regulates GO:1900812 ! helvolic acid biosynthetic process created_by: di creation_date: 2012-06-07T09:39:05Z [Term] id: GO:1900843 name: regulation of monodictyphenone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of monodictyphenone anabolism" EXACT [GOC:TermGenie] synonym: "regulation of monodictyphenone biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of monodictyphenone formation" EXACT [GOC:TermGenie] synonym: "regulation of monodictyphenone synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900815 ! monodictyphenone biosynthetic process relationship: regulates GO:1900815 ! monodictyphenone biosynthetic process created_by: di creation_date: 2012-06-07T09:40:38Z [Term] id: GO:1900844 name: negative regulation of monodictyphenone biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process relationship: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process created_by: di creation_date: 2012-06-07T09:41:00Z [Term] id: GO:1900845 name: positive regulation of monodictyphenone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "upregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process relationship: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process created_by: di creation_date: 2012-06-07T09:41:08Z [Term] id: GO:1900846 name: regulation of naphtho-gamma-pyrone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie] synonym: "regulation of naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process relationship: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process created_by: di creation_date: 2012-06-07T09:42:41Z [Term] id: GO:1900847 name: negative regulation of naphtho-gamma-pyrone biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process relationship: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process created_by: di creation_date: 2012-06-07T09:43:03Z [Term] id: GO:1900848 name: positive regulation of naphtho-gamma-pyrone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process relationship: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process created_by: di creation_date: 2012-06-07T09:43:11Z [Term] id: GO:1900849 name: regulation of pseurotin A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of pseurotin A anabolism" EXACT [GOC:TermGenie] synonym: "regulation of pseurotin A biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of pseurotin A formation" EXACT [GOC:TermGenie] synonym: "regulation of pseurotin A synthesis" EXACT [GOC:TermGenie] synonym: "regulation of Pseurotin anabolism" RELATED [GOC:TermGenie] synonym: "regulation of Pseurotin biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of Pseurotin biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of Pseurotin formation" RELATED [GOC:TermGenie] synonym: "regulation of Pseurotin synthesis" RELATED [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900790 ! pseurotin A biosynthetic process relationship: regulates GO:1900790 ! pseurotin A biosynthetic process created_by: di creation_date: 2012-06-07T09:45:27Z [Term] id: GO:1900850 name: negative regulation of pseurotin A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process relationship: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process created_by: di creation_date: 2012-06-07T09:45:49Z [Term] id: GO:1900851 name: positive regulation of pseurotin A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900790 ! pseurotin A biosynthetic process relationship: positively_regulates GO:1900790 ! pseurotin A biosynthetic process created_by: di creation_date: 2012-06-07T09:45:56Z [Term] id: GO:1900852 name: regulation of terrequinone A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of terrequinone A anabolism" EXACT [GOC:TermGenie] synonym: "regulation of terrequinone A biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of terrequinone A formation" EXACT [GOC:TermGenie] synonym: "regulation of terrequinone A synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900796 ! terrequinone A biosynthetic process relationship: regulates GO:1900796 ! terrequinone A biosynthetic process created_by: di creation_date: 2012-06-07T09:47:09Z [Term] id: GO:1900853 name: negative regulation of terrequinone A biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900796 ! terrequinone A biosynthetic process relationship: negatively_regulates GO:1900796 ! terrequinone A biosynthetic process created_by: di creation_date: 2012-06-07T09:47:30Z [Term] id: GO:1900854 name: positive regulation of terrequinone A biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900796 ! terrequinone A biosynthetic process relationship: positively_regulates GO:1900796 ! terrequinone A biosynthetic process created_by: di creation_date: 2012-06-07T09:47:38Z [Term] id: GO:1900855 name: regulation of fumitremorgin B biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of fumitremorgin B anabolism" EXACT [GOC:TermGenie] synonym: "regulation of fumitremorgin B biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of fumitremorgin B formation" EXACT [GOC:TermGenie] synonym: "regulation of fumitremorgin B synthesis" EXACT [GOC:TermGenie] synonym: "regulation of Lanosulin anabolism" RELATED [GOC:TermGenie] synonym: "regulation of Lanosulin biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of Lanosulin biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of Lanosulin formation" RELATED [GOC:TermGenie] synonym: "regulation of Lanosulin synthesis" RELATED [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900772 ! fumitremorgin B biosynthetic process relationship: regulates GO:1900772 ! fumitremorgin B biosynthetic process created_by: di creation_date: 2012-06-07T09:50:37Z [Term] id: GO:1900856 name: negative regulation of fumitremorgin B biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900772 ! fumitremorgin B biosynthetic process relationship: negatively_regulates GO:1900772 ! fumitremorgin B biosynthetic process created_by: di creation_date: 2012-06-07T09:51:01Z [Term] id: GO:1900857 name: positive regulation of fumitremorgin B biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900772 ! fumitremorgin B biosynthetic process relationship: positively_regulates GO:1900772 ! fumitremorgin B biosynthetic process created_by: di creation_date: 2012-06-07T09:51:09Z [Term] id: GO:1900858 name: regulation of brevianamide F biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of brevianamide F anabolism" EXACT [GOC:TermGenie] synonym: "regulation of brevianamide F biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of brevianamide F formation" EXACT [GOC:TermGenie] synonym: "regulation of brevianamide F synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900805 ! brevianamide F biosynthetic process relationship: regulates GO:1900805 ! brevianamide F biosynthetic process created_by: di creation_date: 2012-06-07T09:52:56Z [Term] id: GO:1900859 name: negative regulation of brevianamide F biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900805 ! brevianamide F biosynthetic process relationship: negatively_regulates GO:1900805 ! brevianamide F biosynthetic process created_by: di creation_date: 2012-06-07T09:53:17Z [Term] id: GO:1900860 name: positive regulation of brevianamide F biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "up regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900805 ! brevianamide F biosynthetic process relationship: positively_regulates GO:1900805 ! brevianamide F biosynthetic process created_by: di creation_date: 2012-06-07T09:53:25Z [Term] id: GO:1900861 name: regulation of cordyol C biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900799 ! cordyol C biosynthetic process relationship: regulates GO:1900799 ! cordyol C biosynthetic process created_by: di creation_date: 2012-06-07T01:56:16Z [Term] id: GO:1900862 name: negative regulation of cordyol C biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900861 ! regulation of cordyol C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900799 ! cordyol C biosynthetic process relationship: negatively_regulates GO:1900799 ! cordyol C biosynthetic process created_by: di creation_date: 2012-06-07T01:56:38Z [Term] id: GO:1900863 name: positive regulation of cordyol C biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of cordyol C biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900861 ! regulation of cordyol C biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900799 ! cordyol C biosynthetic process relationship: positively_regulates GO:1900799 ! cordyol C biosynthetic process created_by: di creation_date: 2012-06-07T01:56:46Z [Term] id: GO:1900864 name: mitochondrial RNA modification namespace: biological_process def: "Any RNA modification that takes place in mitochondrion." [GOC:TermGenie] synonym: "mitochondrial RNA editing" NARROW [GOC:TermGenie] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0009451 ! RNA modification intersection_of: GO:0009451 ! RNA modification intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: tb creation_date: 2012-06-11T10:49:56Z [Term] id: GO:1900865 name: chloroplast RNA modification namespace: biological_process def: "Any RNA modification that takes place in chloroplast." [GOC:TermGenie] synonym: "RNA editing in chloroplast" NARROW [GOC:TermGenie] is_a: GO:0009451 ! RNA modification intersection_of: GO:0009451 ! RNA modification intersection_of: occurs_in GO:0009507 ! chloroplast relationship: occurs_in GO:0009507 ! chloroplast created_by: tb creation_date: 2012-06-11T10:58:04Z [Term] id: GO:1900866 name: glycolate transport namespace: biological_process def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015893 ! drug transport created_by: pr creation_date: 2012-06-12T04:29:56Z [Term] id: GO:1900867 name: sarcinapterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sarcinapterin." [GOC:mengo_curators, GOC:TermGenie] synonym: "sarcinapterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:2001115 ! methanopterin-containing compound metabolic process created_by: tt creation_date: 2012-06-12T04:34:10Z [Term] id: GO:1900868 name: sarcinapterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sarcinapterin." [GOC:mengo_curators, GOC:TermGenie] synonym: "sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "sarcinapterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1900867 ! sarcinapterin metabolic process is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process created_by: tt creation_date: 2012-06-12T04:34:33Z [Term] id: GO:1900869 name: tatiopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tatiopterin." [GOC:mengo_curators, GOC:TermGenie] synonym: "tatiopterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process created_by: tt creation_date: 2012-06-12T04:43:57Z [Term] id: GO:1900870 name: tatiopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tatiopterin." [GOC:mengo_curators, GOC:TermGenie] synonym: "tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "tatiopterin formation" EXACT [GOC:TermGenie] synonym: "tatiopterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900869 ! tatiopterin metabolic process created_by: tt creation_date: 2012-06-12T04:44:19Z [Term] id: GO:1900871 name: chloroplast mRNA modification namespace: biological_process def: "The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:TermGenie, PMID:1653905] synonym: "chloroplast mRNA editing" NARROW [] synonym: "mRNA editing in chloroplast" NARROW [GOC:TermGenie] is_a: GO:0016556 ! mRNA modification is_a: GO:1900865 ! chloroplast RNA modification intersection_of: GO:0016556 ! mRNA modification intersection_of: occurs_in GO:0009507 ! chloroplast created_by: dhl creation_date: 2012-06-12T06:13:58Z [Term] id: GO:1900872 name: pentadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "pentadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T01:45:22Z [Term] id: GO:1900873 name: pentadec-1-ene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "pentadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "pentadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "pentadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "pentadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900872 ! pentadec-1-ene metabolic process created_by: tt creation_date: 2012-06-13T01:45:45Z [Term] id: GO:1900874 name: heptadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T01:49:51Z [Term] id: GO:1900875 name: heptadec-1-ene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0042811 ! pheromone biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900874 ! heptadec-1-ene metabolic process created_by: tt creation_date: 2012-06-13T01:50:11Z [Term] id: GO:1900876 name: nonadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "nonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T01:52:09Z [Term] id: GO:1900877 name: nonadec-1-ene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "nonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900876 ! nonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-13T01:52:37Z [Term] id: GO:1900878 name: (Z)-nonadeca-1,14-diene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie] synonym: "(Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] is_a: GO:1900673 ! olefin metabolic process created_by: tt creation_date: 2012-06-13T02:09:18Z [Term] id: GO:1900879 name: (Z)-nonadeca-1,14-diene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie] synonym: "(Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "(Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "(Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "(Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:1900674 ! olefin biosynthetic process is_a: GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process created_by: tt creation_date: 2012-06-13T02:09:39Z [Term] id: GO:1900880 name: 18-methylnonadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T02:26:28Z [Term] id: GO:1900881 name: 18-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900880 ! 18-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-13T02:26:55Z [Term] id: GO:1900882 name: 17-methylnonadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T02:35:37Z [Term] id: GO:1900883 name: 17-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900882 ! 17-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-13T02:35:59Z [Term] id: GO:1900884 name: regulation of tridecane biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "regulation of tridecane synthesis" EXACT [GOC:TermGenie] is_a: GO:1900893 ! regulation of tridecane metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900632 ! tridecane biosynthetic process relationship: regulates GO:1900632 ! tridecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:00:31Z [Term] id: GO:1900885 name: negative regulation of tridecane biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "down regulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tridecane anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of tridecane biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of tridecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tridecane formation" NARROW [GOC:TermGenie] synonym: "inhibition of tridecane synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tridecane synthesis" EXACT [GOC:TermGenie] is_a: GO:1900884 ! regulation of tridecane biosynthetic process is_a: GO:1900894 ! negative regulation of tridecane metabolic process is_a: GO:1901578 ! negative regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900632 ! tridecane biosynthetic process relationship: negatively_regulates GO:1900632 ! tridecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:00:53Z [Term] id: GO:1900886 name: positive regulation of tridecane biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tridecane anabolism" NARROW [GOC:TermGenie] synonym: "activation of tridecane biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of tridecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tridecane formation" NARROW [GOC:TermGenie] synonym: "activation of tridecane synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane formation" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane synthesis" EXACT [GOC:TermGenie] is_a: GO:1900884 ! regulation of tridecane biosynthetic process is_a: GO:1900895 ! positive regulation of tridecane metabolic process is_a: GO:1901579 ! positive regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900632 ! tridecane biosynthetic process relationship: positively_regulates GO:1900632 ! tridecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:01:01Z [Term] id: GO:1900887 name: regulation of pentadecane biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of pentadecane anabolism" EXACT [GOC:TermGenie] synonym: "regulation of pentadecane biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of pentadecane formation" EXACT [GOC:TermGenie] synonym: "regulation of pentadecane synthesis" EXACT [GOC:TermGenie] is_a: GO:1900890 ! regulation of pentadecane metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900634 ! pentadecane biosynthetic process relationship: regulates GO:1900634 ! pentadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:03:32Z [Term] id: GO:1900888 name: negative regulation of pentadecane biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "down regulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "down-regulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "downregulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "inhibition of pentadecane biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of pentadecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of pentadecane formation" RELATED [GOC:TermGenie] synonym: "inhibition of pentadecane synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "negative regulation of pentadecane synthesis" RELATED [GOC:TermGenie] is_a: GO:1900887 ! regulation of pentadecane biosynthetic process is_a: GO:1900891 ! negative regulation of pentadecane metabolic process is_a: GO:1901578 ! negative regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900634 ! pentadecane biosynthetic process relationship: negatively_regulates GO:1900634 ! pentadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:03:57Z [Term] id: GO:1900889 name: positive regulation of pentadecane biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of pentadecane anabolism" NARROW [GOC:TermGenie] synonym: "activation of pentadecane biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of pentadecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of pentadecane formation" NARROW [GOC:TermGenie] synonym: "activation of pentadecane synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "positive regulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "up regulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "up-regulation of pentadecane synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of pentadecane anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of pentadecane formation" RELATED [GOC:TermGenie] synonym: "upregulation of pentadecane synthesis" RELATED [GOC:TermGenie] is_a: GO:1900887 ! regulation of pentadecane biosynthetic process is_a: GO:1900892 ! positive regulation of pentadecane metabolic process is_a: GO:1901579 ! positive regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900634 ! pentadecane biosynthetic process relationship: positively_regulates GO:1900634 ! pentadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:04:04Z [Term] id: GO:1900890 name: regulation of pentadecane metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of pentadecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900633 ! pentadecane metabolic process relationship: regulates GO:1900633 ! pentadecane metabolic process created_by: tt creation_date: 2012-06-13T03:05:48Z [Term] id: GO:1900891 name: negative regulation of pentadecane metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of pentadecane metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of pentadecane metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of pentadecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900890 ! regulation of pentadecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900633 ! pentadecane metabolic process relationship: negatively_regulates GO:1900633 ! pentadecane metabolic process created_by: tt creation_date: 2012-06-13T03:06:11Z [Term] id: GO:1900892 name: positive regulation of pentadecane metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of pentadecane metabolic process" NARROW [GOC:TermGenie] synonym: "activation of pentadecane metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of pentadecane metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of pentadecane metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of pentadecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900890 ! regulation of pentadecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900633 ! pentadecane metabolic process relationship: positively_regulates GO:1900633 ! pentadecane metabolic process created_by: tt creation_date: 2012-06-13T03:06:20Z [Term] id: GO:1900893 name: regulation of tridecane metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tridecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900631 ! tridecane metabolic process relationship: regulates GO:1900631 ! tridecane metabolic process created_by: tt creation_date: 2012-06-13T03:14:40Z [Term] id: GO:1900894 name: negative regulation of tridecane metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of tridecane metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tridecane metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of tridecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900893 ! regulation of tridecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900631 ! tridecane metabolic process relationship: negatively_regulates GO:1900631 ! tridecane metabolic process created_by: tt creation_date: 2012-06-13T03:15:03Z [Term] id: GO:1900895 name: positive regulation of tridecane metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tridecane metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tridecane metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tridecane metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of tridecane metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tridecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900893 ! regulation of tridecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900631 ! tridecane metabolic process relationship: positively_regulates GO:1900631 ! tridecane metabolic process created_by: tt creation_date: 2012-06-13T03:15:11Z [Term] id: GO:1900896 name: regulation of heptadecane biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of heptadecane anabolism" EXACT [GOC:TermGenie] synonym: "regulation of heptadecane biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of heptadecane formation" EXACT [GOC:TermGenie] synonym: "regulation of heptadecane synthesis" EXACT [GOC:TermGenie] is_a: GO:1900899 ! regulation of heptadecane metabolic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900636 ! heptadecane biosynthetic process relationship: regulates GO:1900636 ! heptadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:27:38Z [Term] id: GO:1900897 name: negative regulation of heptadecane biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "down regulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "down-regulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "downregulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of heptadecane anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of heptadecane biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of heptadecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of heptadecane formation" NARROW [GOC:TermGenie] synonym: "inhibition of heptadecane synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "negative regulation of heptadecane synthesis" RELATED [GOC:TermGenie] is_a: GO:1900896 ! regulation of heptadecane biosynthetic process is_a: GO:1900900 ! negative regulation of heptadecane metabolic process is_a: GO:1901578 ! negative regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900636 ! heptadecane biosynthetic process relationship: negatively_regulates GO:1900636 ! heptadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:28:02Z [Term] id: GO:1900898 name: positive regulation of heptadecane biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of heptadecane anabolism" NARROW [GOC:TermGenie] synonym: "activation of heptadecane biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of heptadecane biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of heptadecane formation" NARROW [GOC:TermGenie] synonym: "activation of heptadecane synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "positive regulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "up regulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "up-regulation of heptadecane synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of heptadecane anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of heptadecane formation" RELATED [GOC:TermGenie] synonym: "upregulation of heptadecane synthesis" RELATED [GOC:TermGenie] is_a: GO:1900896 ! regulation of heptadecane biosynthetic process is_a: GO:1900901 ! positive regulation of heptadecane metabolic process is_a: GO:1901579 ! positive regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900636 ! heptadecane biosynthetic process relationship: positively_regulates GO:1900636 ! heptadecane biosynthetic process created_by: tt creation_date: 2012-06-13T03:28:10Z [Term] id: GO:1900899 name: regulation of heptadecane metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of heptadecane metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900635 ! heptadecane metabolic process relationship: regulates GO:1900635 ! heptadecane metabolic process created_by: tt creation_date: 2012-06-13T03:30:03Z [Term] id: GO:1900900 name: negative regulation of heptadecane metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of heptadecane metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of heptadecane metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of heptadecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900899 ! regulation of heptadecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900635 ! heptadecane metabolic process relationship: negatively_regulates GO:1900635 ! heptadecane metabolic process created_by: tt creation_date: 2012-06-13T03:30:25Z [Term] id: GO:1900901 name: positive regulation of heptadecane metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of heptadecane metabolic process" NARROW [GOC:TermGenie] synonym: "activation of heptadecane metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of heptadecane metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of heptadecane metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of heptadecane metabolism" RELATED [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900899 ! regulation of heptadecane metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900635 ! heptadecane metabolic process relationship: positively_regulates GO:1900635 ! heptadecane metabolic process created_by: tt creation_date: 2012-06-13T03:30:33Z [Term] id: GO:1900902 name: regulation of hexadecanal biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of hexadecanal anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hexadecanal biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hexadecanal formation" EXACT [GOC:TermGenie] synonym: "regulation of hexadecanal synthesis" EXACT [GOC:TermGenie] synonym: "regulation of palmitaldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of palmitaldehyde biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900905 ! regulation of hexadecanal metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006634 ! hexadecanal biosynthetic process relationship: regulates GO:0006634 ! hexadecanal biosynthetic process created_by: tt creation_date: 2012-06-13T03:33:10Z [Term] id: GO:1900903 name: negative regulation of hexadecanal biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "down regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "down-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "downregulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of hexadecanal anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of hexadecanal biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of hexadecanal biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hexadecanal formation" NARROW [GOC:TermGenie] synonym: "inhibition of hexadecanal synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of palmitaldehyde biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "negative regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process is_a: GO:1900906 ! negative regulation of hexadecanal metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process relationship: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process created_by: tt creation_date: 2012-06-13T03:33:34Z [Term] id: GO:1900904 name: positive regulation of hexadecanal biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of hexadecanal anabolism" NARROW [GOC:TermGenie] synonym: "activation of hexadecanal biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of hexadecanal biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hexadecanal formation" NARROW [GOC:TermGenie] synonym: "activation of hexadecanal synthesis" NARROW [GOC:TermGenie] synonym: "activation of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "positive regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "up regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "up-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of hexadecanal anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hexadecanal formation" RELATED [GOC:TermGenie] synonym: "upregulation of hexadecanal synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process is_a: GO:1900907 ! positive regulation of hexadecanal metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006634 ! hexadecanal biosynthetic process relationship: positively_regulates GO:0006634 ! hexadecanal biosynthetic process created_by: tt creation_date: 2012-06-13T03:33:42Z [Term] id: GO:1900905 name: regulation of hexadecanal metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of hexadecanal metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046458 ! hexadecanal metabolic process relationship: regulates GO:0046458 ! hexadecanal metabolic process created_by: tt creation_date: 2012-06-13T03:35:27Z [Term] id: GO:1900906 name: negative regulation of hexadecanal metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of hexadecanal metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900905 ! regulation of hexadecanal metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046458 ! hexadecanal metabolic process relationship: negatively_regulates GO:0046458 ! hexadecanal metabolic process created_by: tt creation_date: 2012-06-13T03:35:54Z [Term] id: GO:1900907 name: positive regulation of hexadecanal metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of hexadecanal metabolic process" NARROW [GOC:TermGenie] synonym: "activation of hexadecanal metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of hexadecanal metabolism" RELATED [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900905 ! regulation of hexadecanal metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046458 ! hexadecanal metabolic process relationship: positively_regulates GO:0046458 ! hexadecanal metabolic process created_by: tt creation_date: 2012-06-13T03:36:02Z [Term] id: GO:1900908 name: regulation of olefin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of olefin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900673 ! olefin metabolic process relationship: regulates GO:1900673 ! olefin metabolic process created_by: tt creation_date: 2012-06-13T04:18:29Z [Term] id: GO:1900909 name: negative regulation of olefin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of olefin metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of olefin metabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of olefin metabolism" RELATED [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900673 ! olefin metabolic process relationship: negatively_regulates GO:1900673 ! olefin metabolic process created_by: tt creation_date: 2012-06-13T04:18:50Z [Term] id: GO:1900910 name: positive regulation of olefin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of olefin metabolic process" NARROW [GOC:TermGenie] synonym: "activation of olefin metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of olefin metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of olefin metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of olefin metabolism" RELATED [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900673 ! olefin metabolic process relationship: positively_regulates GO:1900673 ! olefin metabolic process created_by: tt creation_date: 2012-06-13T04:18:58Z [Term] id: GO:1900911 name: regulation of olefin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of olefin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of olefin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of olefin formation" EXACT [GOC:TermGenie] synonym: "regulation of olefin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900674 ! olefin biosynthetic process relationship: regulates GO:1900674 ! olefin biosynthetic process created_by: tt creation_date: 2012-06-13T04:20:08Z [Term] id: GO:1900912 name: negative regulation of olefin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "down regulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "down-regulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of olefin formation" RELATED [GOC:TermGenie] synonym: "downregulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of olefin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of olefin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of olefin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of olefin formation" NARROW [GOC:TermGenie] synonym: "inhibition of olefin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "negative regulation of olefin synthesis" RELATED [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900911 ! regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900674 ! olefin biosynthetic process relationship: negatively_regulates GO:1900674 ! olefin biosynthetic process created_by: tt creation_date: 2012-06-13T04:20:30Z [Term] id: GO:1900913 name: positive regulation of olefin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of olefin anabolism" NARROW [GOC:TermGenie] synonym: "activation of olefin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of olefin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of olefin formation" NARROW [GOC:TermGenie] synonym: "activation of olefin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "positive regulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "up regulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of olefin formation" RELATED [GOC:TermGenie] synonym: "up-regulation of olefin synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of olefin anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of olefin biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of olefin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of olefin formation" RELATED [GOC:TermGenie] synonym: "upregulation of olefin synthesis" RELATED [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900911 ! regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900674 ! olefin biosynthetic process relationship: positively_regulates GO:1900674 ! olefin biosynthetic process created_by: tt creation_date: 2012-06-13T04:20:38Z [Term] id: GO:1900914 name: regulation of octadecene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 1-octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of octadecene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of octadecene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of octadecene formation" EXACT [GOC:TermGenie] synonym: "regulation of octadecene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900917 ! regulation of octadecene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900682 ! octadecene biosynthetic process relationship: regulates GO:1900682 ! octadecene biosynthetic process created_by: tt creation_date: 2012-06-13T04:24:24Z [Term] id: GO:1900915 name: negative regulation of octadecene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "down regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "down regulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "down-regulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "downregulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "downregulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of 1-octadecene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene formation" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "negative regulation of octadecene synthesis" RELATED [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900914 ! regulation of octadecene biosynthetic process is_a: GO:1900918 ! negative regulation of octadecene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900682 ! octadecene biosynthetic process relationship: negatively_regulates GO:1900682 ! octadecene biosynthetic process created_by: tt creation_date: 2012-06-13T04:24:47Z [Term] id: GO:1900916 name: positive regulation of octadecene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "activation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of octadecene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of octadecene formation" RELATED [GOC:TermGenie] synonym: "activation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "positive regulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "up regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "up regulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "up-regulation of octadecene synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of octadecene anabolism" RELATED [GOC:TermGenie] synonym: "upregulation of octadecene biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of octadecene formation" RELATED [GOC:TermGenie] synonym: "upregulation of octadecene synthesis" RELATED [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900914 ! regulation of octadecene biosynthetic process is_a: GO:1900919 ! positive regulation of octadecene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900682 ! octadecene biosynthetic process relationship: positively_regulates GO:1900682 ! octadecene biosynthetic process created_by: tt creation_date: 2012-06-13T04:24:55Z [Term] id: GO:1900917 name: regulation of octadecene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of octadecene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900681 ! octadecene metabolic process relationship: regulates GO:1900681 ! octadecene metabolic process created_by: tt creation_date: 2012-06-13T04:26:11Z [Term] id: GO:1900918 name: negative regulation of octadecene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of octadecene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of octadecene metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of octadecene metabolism" RELATED [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900917 ! regulation of octadecene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900681 ! octadecene metabolic process relationship: negatively_regulates GO:1900681 ! octadecene metabolic process created_by: tt creation_date: 2012-06-13T04:26:34Z [Term] id: GO:1900919 name: positive regulation of octadecene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of octadecene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of octadecene metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of octadecene metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of octadecene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of octadecene metabolism" RELATED [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900917 ! regulation of octadecene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900681 ! octadecene metabolic process relationship: positively_regulates GO:1900681 ! octadecene metabolic process created_by: tt creation_date: 2012-06-13T04:26:42Z [Term] id: GO:1900923 name: regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "regulation of glycine import" BROAD [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903804 ! glycine import across plasma membrane relationship: regulates GO:1903804 ! glycine import across plasma membrane created_by: al creation_date: 2012-06-13T07:40:11Z [Term] id: GO:1900924 name: negative regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "down regulation of glycine import" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] synonym: "negative regulation of glycine import" BROAD [] is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903804 ! glycine import across plasma membrane relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane created_by: al creation_date: 2012-06-13T07:40:32Z [Term] id: GO:1900925 name: positive regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie] synonym: "activation of glycine import" NARROW [GOC:TermGenie] synonym: "positive regulation of glycine import" BROAD [] synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903804 ! glycine import across plasma membrane relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane created_by: al creation_date: 2012-06-13T07:40:40Z [Term] id: GO:1900926 name: regulation of L-threonine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] synonym: "regulation of L-threonine import" BROAD [] synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903807 ! L-threonine import across plasma membrane relationship: regulates GO:1903807 ! L-threonine import across plasma membrane created_by: al creation_date: 2012-06-13T07:41:32Z [Term] id: GO:1900927 name: negative regulation of L-threonine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] synonym: "down regulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "down regulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "downregulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-threonine import" NARROW [GOC:TermGenie] synonym: "inhibition of L-threonine uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of L-threonine uptake" RELATED [GOC:TermGenie] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane relationship: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane created_by: al creation_date: 2012-06-13T07:41:52Z [Term] id: GO:1900928 name: positive regulation of L-threonine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] synonym: "activation of L-threonine import" NARROW [GOC:TermGenie] synonym: "activation of L-threonine uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-threonine import" BROAD [] synonym: "positive regulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "up regulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "up regulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-threonine uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-threonine import" EXACT [GOC:TermGenie] synonym: "upregulation of L-threonine uptake" RELATED [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903807 ! L-threonine import across plasma membrane relationship: positively_regulates GO:1903807 ! L-threonine import across plasma membrane created_by: al creation_date: 2012-06-13T07:42:00Z [Term] id: GO:1900929 name: regulation of L-tyrosine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] synonym: "regulation of L-tyrosine import" BROAD [] synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: regulates GO:1903808 ! L-tyrosine import across plasma membrane created_by: al creation_date: 2012-06-13T07:42:52Z [Term] id: GO:1900930 name: negative regulation of L-tyrosine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] synonym: "down regulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "down regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "downregulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-tyrosine import" NARROW [GOC:TermGenie] synonym: "inhibition of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "negative regulation of L-tyrosine import" BROAD [] synonym: "negative regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane created_by: al creation_date: 2012-06-13T07:43:14Z [Term] id: GO:1900931 name: positive regulation of L-tyrosine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] synonym: "activation of L-tyrosine import" NARROW [GOC:TermGenie] synonym: "activation of L-tyrosine uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-tyrosine import" BROAD [] synonym: "positive regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "up regulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "up regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-tyrosine import" EXACT [GOC:TermGenie] synonym: "upregulation of L-tyrosine uptake" RELATED [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane created_by: al creation_date: 2012-06-13T07:43:21Z [Term] id: GO:1900932 name: regulation of nonadec-1-ene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900876 ! nonadec-1-ene metabolic process relationship: regulates GO:1900876 ! nonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:11:28Z [Term] id: GO:1900933 name: negative regulation of nonadec-1-ene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process relationship: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:11:50Z [Term] id: GO:1900934 name: positive regulation of nonadec-1-ene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process relationship: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:11:58Z [Term] id: GO:1900935 name: regulation of nonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900877 ! nonadec-1-ene biosynthetic process relationship: regulates GO:1900877 ! nonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:13:34Z [Term] id: GO:1900936 name: negative regulation of nonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "downregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "inhibition of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "negative regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900933 ! negative regulation of nonadec-1-ene metabolic process is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process relationship: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:13:56Z [Term] id: GO:1900937 name: positive regulation of nonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "activation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "activation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "positive regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "upregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900934 ! positive regulation of nonadec-1-ene metabolic process is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process relationship: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:14:04Z [Term] id: GO:1900938 name: regulation of (Z)-nonadeca-1,14-diene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process relationship: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process created_by: tt creation_date: 2012-06-14T03:15:37Z [Term] id: GO:1900939 name: negative regulation of (Z)-nonadeca-1,14-diene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process relationship: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process created_by: tt creation_date: 2012-06-14T03:15:58Z [Term] id: GO:1900940 name: positive regulation of (Z)-nonadeca-1,14-diene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process relationship: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process created_by: tt creation_date: 2012-06-14T03:16:05Z [Term] id: GO:1900941 name: regulation of (Z)-nonadeca-1,14-diene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process relationship: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process created_by: tt creation_date: 2012-06-14T03:17:32Z [Term] id: GO:1900942 name: negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "down regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "down-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "downregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie] synonym: "inhibition of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "negative regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900939 ! negative regulation of (Z)-nonadeca-1,14-diene metabolic process is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process relationship: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process created_by: tt creation_date: 2012-06-14T03:17:54Z [Term] id: GO:1900943 name: positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie] synonym: "activation of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "positive regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "up regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "up-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] synonym: "upregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900940 ! positive regulation of (Z)-nonadeca-1,14-diene metabolic process is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process relationship: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process created_by: tt creation_date: 2012-06-14T03:18:01Z [Term] id: GO:1900944 name: regulation of isoprene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "regulation of isoprene metabolism" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043611 ! isoprene metabolic process relationship: regulates GO:0043611 ! isoprene metabolic process created_by: tt creation_date: 2012-06-14T03:19:13Z [Term] id: GO:1900945 name: negative regulation of isoprene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of hemiterpene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of hemiterpene metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of isoprene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of isoprene metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of isoprene metabolism" EXACT [GOC:TermGenie] is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900944 ! regulation of isoprene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043611 ! isoprene metabolic process relationship: negatively_regulates GO:0043611 ! isoprene metabolic process created_by: tt creation_date: 2012-06-14T03:19:33Z [Term] id: GO:1900946 name: positive regulation of isoprene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie] synonym: "activation of hemiterpene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of hemiterpene metabolism" NARROW [GOC:TermGenie] synonym: "activation of isoprene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of isoprene metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of isoprene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of hemiterpene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of isoprene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of isoprene metabolism" EXACT [GOC:TermGenie] is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900944 ! regulation of isoprene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043611 ! isoprene metabolic process relationship: positively_regulates GO:0043611 ! isoprene metabolic process created_by: tt creation_date: 2012-06-14T03:19:41Z [Term] id: GO:1900947 name: regulation of isoprene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900944 ! regulation of isoprene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043612 ! isoprene biosynthetic process relationship: regulates GO:0043612 ! isoprene biosynthetic process created_by: tt creation_date: 2012-06-14T03:21:26Z [Term] id: GO:1900948 name: negative regulation of isoprene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hemiterpene biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemiterpene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of isoprene biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900945 ! negative regulation of isoprene metabolic process is_a: GO:1900947 ! regulation of isoprene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043612 ! isoprene biosynthetic process relationship: negatively_regulates GO:0043612 ! isoprene biosynthetic process created_by: tt creation_date: 2012-06-14T03:21:47Z [Term] id: GO:1900949 name: positive regulation of isoprene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hemiterpene biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of hemiterpene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of isoprene biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900946 ! positive regulation of isoprene metabolic process is_a: GO:1900947 ! regulation of isoprene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043612 ! isoprene biosynthetic process relationship: positively_regulates GO:0043612 ! isoprene biosynthetic process created_by: tt creation_date: 2012-06-14T03:21:54Z [Term] id: GO:1900950 name: regulation of 18-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process relationship: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:23:34Z [Term] id: GO:1900951 name: negative regulation of 18-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "negative regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process is_a: GO:1900954 ! negative regulation of 18-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process relationship: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:23:55Z [Term] id: GO:1900952 name: positive regulation of 18-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "positive regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process is_a: GO:1900955 ! positive regulation of 18-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process relationship: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:24:02Z [Term] id: GO:1900953 name: regulation of 18-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process relationship: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:25:16Z [Term] id: GO:1900954 name: negative regulation of 18-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process relationship: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:25:37Z [Term] id: GO:1900955 name: positive regulation of 18-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process relationship: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:25:44Z [Term] id: GO:1900956 name: regulation of 17-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process relationship: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:27:18Z [Term] id: GO:1900957 name: negative regulation of 17-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "negative regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process is_a: GO:1900960 ! negative regulation of 17-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process relationship: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:27:39Z [Term] id: GO:1900958 name: positive regulation of 17-methylnonadec-1-ene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "positive regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process is_a: GO:1900961 ! positive regulation of 17-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process relationship: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process created_by: tt creation_date: 2012-06-14T03:27:46Z [Term] id: GO:1900959 name: regulation of 17-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:1900908 ! regulation of olefin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process relationship: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:29:27Z [Term] id: GO:1900960 name: negative regulation of 17-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1900909 ! negative regulation of olefin metabolic process is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process relationship: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:29:51Z [Term] id: GO:1900961 name: positive regulation of 17-methylnonadec-1-ene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1900910 ! positive regulation of olefin metabolic process is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process relationship: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process created_by: tt creation_date: 2012-06-14T03:29:59Z [Term] id: GO:1900962 name: regulation of methanophenazine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900965 ! regulation of methanophenazine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900630 ! methanophenazine biosynthetic process relationship: regulates GO:1900630 ! methanophenazine biosynthetic process created_by: tt creation_date: 2012-06-14T03:53:15Z [Term] id: GO:1900963 name: negative regulation of methanophenazine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "down regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of methanophenazine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "inhibition of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process is_a: GO:1900966 ! negative regulation of methanophenazine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process relationship: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process created_by: tt creation_date: 2012-06-14T03:53:38Z [Term] id: GO:1900964 name: positive regulation of methanophenazine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "activation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of methanophenazine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "activation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine formation" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process is_a: GO:1900967 ! positive regulation of methanophenazine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900630 ! methanophenazine biosynthetic process relationship: positively_regulates GO:1900630 ! methanophenazine biosynthetic process created_by: tt creation_date: 2012-06-14T03:53:46Z [Term] id: GO:1900965 name: regulation of methanophenazine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900629 ! methanophenazine metabolic process relationship: regulates GO:1900629 ! methanophenazine metabolic process created_by: tt creation_date: 2012-06-14T03:55:26Z [Term] id: GO:1900966 name: negative regulation of methanophenazine metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of methanophenazine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900965 ! regulation of methanophenazine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900629 ! methanophenazine metabolic process relationship: negatively_regulates GO:1900629 ! methanophenazine metabolic process created_by: tt creation_date: 2012-06-14T03:55:49Z [Term] id: GO:1900967 name: positive regulation of methanophenazine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methanophenazine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of methanophenazine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900965 ! regulation of methanophenazine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900629 ! methanophenazine metabolic process relationship: positively_regulates GO:1900629 ! methanophenazine metabolic process created_by: tt creation_date: 2012-06-14T03:55:56Z [Term] id: GO:1900968 name: regulation of sarcinapterin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0042068 ! regulation of pteridine metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900867 ! sarcinapterin metabolic process relationship: regulates GO:1900867 ! sarcinapterin metabolic process created_by: tt creation_date: 2012-06-14T03:58:11Z [Term] id: GO:1900969 name: negative regulation of sarcinapterin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of sarcinapterin metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0045863 ! negative regulation of pteridine metabolic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900968 ! regulation of sarcinapterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900867 ! sarcinapterin metabolic process relationship: negatively_regulates GO:1900867 ! sarcinapterin metabolic process created_by: tt creation_date: 2012-06-14T03:58:35Z [Term] id: GO:1900970 name: positive regulation of sarcinapterin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of sarcinapterin metabolic process" NARROW [GOC:TermGenie] synonym: "activation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0045864 ! positive regulation of pteridine metabolic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900968 ! regulation of sarcinapterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900867 ! sarcinapterin metabolic process relationship: positively_regulates GO:1900867 ! sarcinapterin metabolic process created_by: tt creation_date: 2012-06-14T03:58:43Z [Term] id: GO:1900971 name: regulation of sarcinapterin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900968 ! regulation of sarcinapterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900868 ! sarcinapterin biosynthetic process relationship: regulates GO:1900868 ! sarcinapterin biosynthetic process created_by: tt creation_date: 2012-06-14T03:59:44Z [Term] id: GO:1900972 name: negative regulation of sarcinapterin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "down regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "downregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "inhibition of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900969 ! negative regulation of sarcinapterin metabolic process is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process relationship: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process created_by: tt creation_date: 2012-06-14T04:00:06Z [Term] id: GO:1900973 name: positive regulation of sarcinapterin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "activation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "activation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "up regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin formation" EXACT [GOC:TermGenie] synonym: "upregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900970 ! positive regulation of sarcinapterin metabolic process is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process relationship: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process created_by: tt creation_date: 2012-06-14T04:00:14Z [Term] id: GO:1900974 name: regulation of tatiopterin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900977 ! regulation of tatiopterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900870 ! tatiopterin biosynthetic process relationship: regulates GO:1900870 ! tatiopterin biosynthetic process created_by: tt creation_date: 2012-06-14T04:01:42Z [Term] id: GO:1900975 name: negative regulation of tatiopterin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "down regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tatiopterin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "inhibition of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process is_a: GO:1900978 ! negative regulation of tatiopterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process relationship: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process created_by: tt creation_date: 2012-06-14T04:02:06Z [Term] id: GO:1900976 name: positive regulation of tatiopterin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "activation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of tatiopterin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "activation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin formation" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process is_a: GO:1900979 ! positive regulation of tatiopterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900870 ! tatiopterin biosynthetic process relationship: positively_regulates GO:1900870 ! tatiopterin biosynthetic process created_by: tt creation_date: 2012-06-14T04:02:14Z [Term] id: GO:1900977 name: regulation of tatiopterin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900869 ! tatiopterin metabolic process relationship: regulates GO:1900869 ! tatiopterin metabolic process created_by: tt creation_date: 2012-06-14T04:03:06Z [Term] id: GO:1900978 name: negative regulation of tatiopterin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tatiopterin metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900977 ! regulation of tatiopterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900869 ! tatiopterin metabolic process relationship: negatively_regulates GO:1900869 ! tatiopterin metabolic process created_by: tt creation_date: 2012-06-14T04:03:29Z [Term] id: GO:1900979 name: positive regulation of tatiopterin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tatiopterin metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tatiopterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900977 ! regulation of tatiopterin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900869 ! tatiopterin metabolic process relationship: positively_regulates GO:1900869 ! tatiopterin metabolic process created_by: tt creation_date: 2012-06-14T04:03:37Z [Term] id: GO:1900980 name: regulation of phenazine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002047 ! phenazine biosynthetic process relationship: regulates GO:0002047 ! phenazine biosynthetic process created_by: tt creation_date: 2012-06-14T04:04:39Z [Term] id: GO:1900981 name: negative regulation of phenazine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of phenazine biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1900980 ! regulation of phenazine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002047 ! phenazine biosynthetic process relationship: negatively_regulates GO:0002047 ! phenazine biosynthetic process created_by: tt creation_date: 2012-06-14T04:05:03Z [Term] id: GO:1900982 name: positive regulation of phenazine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of phenazine biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acridizine biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1900980 ! regulation of phenazine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002047 ! phenazine biosynthetic process relationship: positively_regulates GO:0002047 ! phenazine biosynthetic process created_by: tt creation_date: 2012-06-14T04:05:10Z [Term] id: GO:1900983 name: vindoline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] synonym: "vindoline metabolism" EXACT [GOC:TermGenie] is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1900619 ! acetate ester metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: yaf creation_date: 2012-06-14T09:16:29Z [Term] id: GO:1900984 name: vindoline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] synonym: "vindoline breakdown" EXACT [GOC:TermGenie] synonym: "vindoline catabolism" EXACT [GOC:TermGenie] synonym: "vindoline degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1900983 ! vindoline metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process created_by: yaf creation_date: 2012-06-14T09:16:56Z [Term] id: GO:1900985 name: vindoline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] synonym: "vindoline anabolism" EXACT [GOC:TermGenie] synonym: "vindoline biosynthesis" EXACT [GOC:TermGenie] synonym: "vindoline formation" EXACT [GOC:TermGenie] synonym: "vindoline synthesis" EXACT [GOC:TermGenie] is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process is_a: GO:1900983 ! vindoline metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process created_by: yaf creation_date: 2012-06-14T09:17:03Z [Term] id: GO:1900986 name: ajmaline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] synonym: "ajmaline metabolism" EXACT [GOC:TermGenie] is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: yaf creation_date: 2012-06-14T09:47:02Z [Term] id: GO:1900987 name: ajmaline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] synonym: "ajmaline breakdown" EXACT [GOC:TermGenie] synonym: "ajmaline catabolism" EXACT [GOC:TermGenie] synonym: "ajmaline degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:1900986 ! ajmaline metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process created_by: yaf creation_date: 2012-06-14T09:47:26Z [Term] id: GO:1900988 name: ajmaline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] synonym: "ajmaline anabolism" EXACT [GOC:TermGenie] synonym: "ajmaline biosynthesis" EXACT [GOC:TermGenie] synonym: "ajmaline formation" EXACT [GOC:TermGenie] synonym: "ajmaline synthesis" EXACT [GOC:TermGenie] is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process is_a: GO:1900986 ! ajmaline metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: yaf creation_date: 2012-06-14T09:47:33Z [Term] id: GO:1900989 name: scopolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] synonym: "scopolamine metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: yaf creation_date: 2012-06-14T09:47:38Z [Term] id: GO:1900990 name: scopolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] synonym: "scopolamine breakdown" EXACT [GOC:TermGenie] synonym: "scopolamine catabolism" EXACT [GOC:TermGenie] synonym: "scopolamine degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900989 ! scopolamine metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process created_by: yaf creation_date: 2012-06-14T09:48:00Z [Term] id: GO:1900991 name: scopolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] synonym: "scopolamine anabolism" EXACT [GOC:TermGenie] synonym: "scopolamine biosynthesis" EXACT [GOC:TermGenie] synonym: "scopolamine formation" EXACT [GOC:TermGenie] synonym: "scopolamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009710 ! tropane alkaloid biosynthetic process is_a: GO:1900989 ! scopolamine metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: yaf creation_date: 2012-06-14T09:48:07Z [Term] id: GO:1900992 name: (-)-secologanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] synonym: "(-)-secologanin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: yaf creation_date: 2012-06-14T09:51:17Z [Term] id: GO:1900993 name: (-)-secologanin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] synonym: "(-)-secologanin breakdown" EXACT [GOC:TermGenie] synonym: "(-)-secologanin catabolism" EXACT [GOC:TermGenie] synonym: "(-)-secologanin degradation" EXACT [GOC:TermGenie] is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900992 ! (-)-secologanin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901805 ! beta-glucoside catabolic process created_by: yaf creation_date: 2012-06-14T09:51:39Z [Term] id: GO:1900994 name: (-)-secologanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] synonym: "(-)-secologanin anabolism" EXACT [GOC:TermGenie] synonym: "(-)-secologanin biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-secologanin formation" EXACT [GOC:TermGenie] synonym: "(-)-secologanin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016099 ! monoterpenoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:1900992 ! (-)-secologanin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process created_by: yaf creation_date: 2012-06-14T09:51:46Z [Term] id: GO:1900995 name: ubiquinone-6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [CHEBI:52971, GOC:al, GOC:TermGenie] is_a: GO:0048039 ! ubiquinone binding created_by: bf creation_date: 2012-06-14T02:49:15Z [Term] id: GO:1900996 name: benzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272] synonym: "benzene breakdown" EXACT [GOC:TermGenie] synonym: "benzene catabolism" EXACT [GOC:TermGenie] synonym: "benzene degradation" EXACT [GOC:TermGenie] is_a: GO:0018910 ! benzene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: yaf creation_date: 2012-06-14T02:53:38Z [Term] id: GO:1900997 name: benzene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272] synonym: "benzene anabolism" EXACT [GOC:TermGenie] synonym: "benzene biosynthesis" EXACT [GOC:TermGenie] synonym: "benzene formation" EXACT [GOC:TermGenie] synonym: "benzene synthesis" EXACT [GOC:TermGenie] is_a: GO:0018910 ! benzene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: yaf creation_date: 2012-06-14T02:54:01Z [Term] id: GO:1900998 name: nitrobenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923] synonym: "nitrobenzene breakdown" EXACT [GOC:TermGenie] synonym: "nitrobenzene catabolism" EXACT [GOC:TermGenie] synonym: "nitrobenzene degradation" EXACT [GOC:TermGenie] is_a: GO:0018916 ! nitrobenzene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: yaf creation_date: 2012-06-14T02:54:09Z [Term] id: GO:1900999 name: nitrobenzene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923] synonym: "nitrobenzene anabolism" EXACT [GOC:TermGenie] synonym: "nitrobenzene biosynthesis" EXACT [GOC:TermGenie] synonym: "nitrobenzene formation" EXACT [GOC:TermGenie] synonym: "nitrobenzene synthesis" EXACT [GOC:TermGenie] is_a: GO:0018916 ! nitrobenzene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: yaf creation_date: 2012-06-14T02:54:32Z [Term] id: GO:1901000 name: regulation of response to salt stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "regulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0047484 ! regulation of response to osmotic stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009651 ! response to salt stress relationship: regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:19Z [Term] id: GO:1901001 name: negative regulation of response to salt stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "down regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "down regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "down regulation of salinity response" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "down-regulation of salinity response" EXACT [GOC:TermGenie] synonym: "downregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "downregulation of salinity response" EXACT [GOC:TermGenie] synonym: "inhibition of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "inhibition of response to salt stress" NARROW [GOC:TermGenie] synonym: "inhibition of salinity response" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "negative regulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901000 ! regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009651 ! response to salt stress relationship: negatively_regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:43Z [Term] id: GO:1901002 name: positive regulation of response to salt stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] synonym: "activation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "activation of response to salt stress" NARROW [GOC:TermGenie] synonym: "activation of salinity response" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of salinity response" EXACT [GOC:TermGenie] synonym: "up regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "up regulation of salinity response" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "up-regulation of salinity response" EXACT [GOC:TermGenie] synonym: "upregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to salt stress" EXACT [GOC:TermGenie] synonym: "upregulation of salinity response" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901000 ! regulation of response to salt stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009651 ! response to salt stress relationship: positively_regulates GO:0009651 ! response to salt stress created_by: dhl creation_date: 2012-06-14T05:41:50Z [Term] id: GO:1901003 name: negative regulation of fermentation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fermentation." [GOC:TermGenie] synonym: "down regulation of fermentation" EXACT [GOC:TermGenie] synonym: "down-regulation of fermentation" EXACT [GOC:TermGenie] synonym: "downregulation of fermentation" EXACT [GOC:TermGenie] synonym: "inhibition of fermentation" NARROW [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0043465 ! regulation of fermentation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006113 ! fermentation relationship: negatively_regulates GO:0006113 ! fermentation created_by: al creation_date: 2012-06-15T08:21:31Z [Term] id: GO:1901004 name: ubiquinone-6 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie, PMID:1409592] synonym: "coenzyme Q6 metabolic process" EXACT [CHEBI:52971] synonym: "coenzyme Q6 metabolism" EXACT [CHEBI:52971] synonym: "ubiquinone-6 metabolism" EXACT [GOC:TermGenie] is_a: GO:0006743 ! ubiquinone metabolic process created_by: bf creation_date: 2012-06-15T09:59:28Z [Term] id: GO:1901005 name: ubiquinone-6 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone-6." [GOC:TermGenie] synonym: "ubiquinone-6 breakdown" EXACT [GOC:TermGenie] synonym: "ubiquinone-6 catabolism" EXACT [GOC:TermGenie] synonym: "ubiquinone-6 degradation" EXACT [GOC:TermGenie] is_a: GO:0032322 ! ubiquinone catabolic process is_a: GO:1901004 ! ubiquinone-6 metabolic process created_by: bf creation_date: 2012-06-15T09:59:51Z [Term] id: GO:1901006 name: ubiquinone-6 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone-6." [GOC:TermGenie] synonym: "ubiquinone-6 anabolism" EXACT [GOC:TermGenie] synonym: "ubiquinone-6 biosynthesis" EXACT [GOC:TermGenie] synonym: "ubiquinone-6 formation" EXACT [GOC:TermGenie] synonym: "ubiquinone-6 synthesis" EXACT [GOC:TermGenie] is_a: GO:0006744 ! ubiquinone biosynthetic process is_a: GO:1901004 ! ubiquinone-6 metabolic process created_by: bf creation_date: 2012-06-15T09:59:58Z [Term] id: GO:1901007 name: (S)-scoulerine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] synonym: "(S)-scoulerine metabolism" EXACT [GOC:TermGenie] is_a: GO:0033076 ! isoquinoline alkaloid metabolic process created_by: yaf creation_date: 2012-06-15T10:45:48Z [Term] id: GO:1901008 name: (S)-scoulerine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] synonym: "(S)-scoulerine breakdown" EXACT [GOC:TermGenie] synonym: "(S)-scoulerine catabolism" EXACT [GOC:TermGenie] synonym: "(S)-scoulerine degradation" EXACT [GOC:TermGenie] is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901007 ! (S)-scoulerine metabolic process created_by: yaf creation_date: 2012-06-15T10:46:10Z [Term] id: GO:1901009 name: (S)-scoulerine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] synonym: "(S)-scoulerine anabolism" EXACT [GOC:TermGenie] synonym: "(S)-scoulerine biosynthesis" EXACT [GOC:TermGenie] synonym: "(S)-scoulerine formation" EXACT [GOC:TermGenie] synonym: "(S)-scoulerine synthesis" EXACT [GOC:TermGenie] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:1901007 ! (S)-scoulerine metabolic process created_by: yaf creation_date: 2012-06-15T10:46:17Z [Term] id: GO:1901010 name: (S)-reticuline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] synonym: "(S)-reticuline metabolism" EXACT [GOC:TermGenie] is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: yaf creation_date: 2012-06-15T10:46:22Z [Term] id: GO:1901011 name: (S)-reticuline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] synonym: "(S)-reticuline breakdown" EXACT [GOC:TermGenie] synonym: "(S)-reticuline catabolism" EXACT [GOC:TermGenie] synonym: "(S)-reticuline degradation" EXACT [GOC:TermGenie] is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901010 ! (S)-reticuline metabolic process created_by: yaf creation_date: 2012-06-15T10:46:45Z [Term] id: GO:1901012 name: (S)-reticuline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] synonym: "(S)-reticuline anabolism" EXACT [GOC:TermGenie] synonym: "(S)-reticuline biosynthesis" EXACT [GOC:TermGenie] synonym: "(S)-reticuline formation" EXACT [GOC:TermGenie] synonym: "(S)-reticuline synthesis" EXACT [GOC:TermGenie] is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process is_a: GO:1901010 ! (S)-reticuline metabolic process created_by: yaf creation_date: 2012-06-15T10:46:52Z [Term] id: GO:1901013 name: 3alpha(S)-strictosidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] synonym: "3alpha(S)-strictosidine metabolism" EXACT [GOC:TermGenie] is_a: GO:0035834 ! indole alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: yaf creation_date: 2012-06-15T10:46:57Z [Term] id: GO:1901014 name: 3alpha(S)-strictosidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] synonym: "3alpha(S)-strictosidine breakdown" EXACT [GOC:TermGenie] synonym: "3alpha(S)-strictosidine catabolism" EXACT [GOC:TermGenie] synonym: "3alpha(S)-strictosidine degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process is_a: GO:1901805 ! beta-glucoside catabolic process created_by: yaf creation_date: 2012-06-15T10:47:19Z [Term] id: GO:1901015 name: 3alpha(S)-strictosidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] synonym: "3alpha(S)-strictosidine anabolism" EXACT [GOC:TermGenie] synonym: "3alpha(S)-strictosidine biosynthesis" EXACT [GOC:TermGenie] synonym: "3alpha(S)-strictosidine formation" EXACT [GOC:TermGenie] synonym: "3alpha(S)-strictosidine synthesis" EXACT [GOC:TermGenie] is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process is_a: GO:1901806 ! beta-glucoside biosynthetic process created_by: yaf creation_date: 2012-06-15T10:47:26Z [Term] id: GO:1901016 name: regulation of potassium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] synonym: "regulation of potassium transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1901379 ! regulation of potassium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015079 ! potassium ion transmembrane transporter activity relationship: regulates GO:0015079 ! potassium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T01:13:49Z [Term] id: GO:1901017 name: negative regulation of potassium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "inhibition of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie] synonym: "inhibition of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "negative regulation of potassium transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015079 ! potassium ion transmembrane transporter activity relationship: negatively_regulates GO:0015079 ! potassium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T01:14:10Z [Term] id: GO:1901018 name: positive regulation of potassium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] synonym: "activation of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie] synonym: "activation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "positive regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "up regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "up regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium transporter activity" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "upregulation of potassium transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015079 ! potassium ion transmembrane transporter activity relationship: positively_regulates GO:0015079 ! potassium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T01:14:18Z [Term] id: GO:1901019 name: regulation of calcium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015085 ! calcium ion transmembrane transporter activity relationship: regulates GO:0015085 ! calcium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T07:54:12Z [Term] id: GO:1901020 name: negative regulation of calcium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015085 ! calcium ion transmembrane transporter activity relationship: negatively_regulates GO:0015085 ! calcium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T07:54:32Z [Term] id: GO:1901021 name: positive regulation of calcium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] synonym: "activation of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015085 ! calcium ion transmembrane transporter activity relationship: positively_regulates GO:0015085 ! calcium ion transmembrane transporter activity created_by: rl creation_date: 2012-06-15T07:54:40Z [Term] id: GO:1901022 name: 4-hydroxyphenylacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] synonym: "4-hydroxyphenylacetate metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process created_by: yaf creation_date: 2012-06-18T02:31:37Z [Term] id: GO:1901023 name: 4-hydroxyphenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] synonym: "4-hydroxyphenylacetate breakdown" EXACT [GOC:TermGenie] synonym: "4-hydroxyphenylacetate catabolism" EXACT [GOC:TermGenie] synonym: "4-hydroxyphenylacetate degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process created_by: yaf creation_date: 2012-06-18T02:31:58Z [Term] id: GO:1901024 name: 4-hydroxyphenylacetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] synonym: "4-hydroxyphenylacetate anabolism" EXACT [GOC:TermGenie] synonym: "4-hydroxyphenylacetate biosynthesis" EXACT [GOC:TermGenie] synonym: "4-hydroxyphenylacetate formation" EXACT [GOC:TermGenie] synonym: "4-hydroxyphenylacetate synthesis" EXACT [GOC:TermGenie] is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process created_by: yaf creation_date: 2012-06-18T02:32:06Z [Term] id: GO:1901025 name: ripoptosome assembly involved in extrinsic apoptotic signaling pathway namespace: biological_process def: "The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400] is_a: GO:0097343 ! ripoptosome assembly intersection_of: GO:0097343 ! ripoptosome assembly intersection_of: part_of GO:0097191 ! extrinsic apoptotic signaling pathway relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway created_by: pr creation_date: 2012-06-19T08:49:33Z [Term] id: GO:1901026 name: ripoptosome assembly involved in necroptotic process namespace: biological_process def: "The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400] synonym: "ripoptosome assembly involved in necroptosis" NARROW [] is_a: GO:0097343 ! ripoptosome assembly intersection_of: GO:0097343 ! ripoptosome assembly intersection_of: part_of GO:0070266 ! necroptotic process relationship: part_of GO:0070266 ! necroptotic process created_by: pr creation_date: 2012-06-19T08:54:28Z [Term] id: GO:1901027 name: dextrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dextrin." [GOC:TermGenie] synonym: "dextrin breakdown" EXACT [GOC:TermGenie] synonym: "dextrin catabolism" EXACT [GOC:TermGenie] synonym: "dextrin degradation" EXACT [GOC:TermGenie] is_a: GO:0009251 ! glucan catabolic process created_by: al creation_date: 2012-06-19T03:12:19Z [Term] id: GO:1901028 name: regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] synonym: "regulation of mitochondrial outer membrane permeabilization" BROAD [] synonym: "regulation of MOMP" EXACT [GOC:TermGenie] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0046902 ! regulation of mitochondrial membrane permeability is_a: GO:0051049 ! regulation of transport is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097345 ! mitochondrial outer membrane permeabilization relationship: regulates GO:0097345 ! mitochondrial outer membrane permeabilization created_by: pr creation_date: 2012-06-20T09:19:16Z [Term] id: GO:1901029 name: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "down regulation of MOMP" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "down-regulation of MOMP" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "downregulation of MOMP" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie] synonym: "inhibition of MOMP" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial outer membrane permeabilization" BROAD [] synonym: "negative regulation of MOMP" EXACT [GOC:TermGenie] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051051 ! negative regulation of transport is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization relationship: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization created_by: pr creation_date: 2012-06-20T09:19:39Z [Term] id: GO:1901030 name: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] comment: Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID. synonym: "activation of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie] synonym: "activation of MOMP" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial outer membrane permeabilization" BROAD [] synonym: "positive regulation of MOMP" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "up regulation of MOMP" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "up-regulation of MOMP" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] synonym: "upregulation of MOMP" EXACT [GOC:TermGenie] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051050 ! positive regulation of transport is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization relationship: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization created_by: pr creation_date: 2012-06-20T09:19:46Z [Term] id: GO:1901031 name: regulation of response to reactive oxygen species namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000302 ! response to reactive oxygen species relationship: regulates GO:0000302 ! response to reactive oxygen species created_by: kmv creation_date: 2012-06-20T07:47:06Z [Term] id: GO:1901032 name: negative regulation of response to reactive oxygen species namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie] synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie] synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000302 ! response to reactive oxygen species relationship: negatively_regulates GO:0000302 ! response to reactive oxygen species created_by: kmv creation_date: 2012-06-20T07:47:28Z [Term] id: GO:1901033 name: positive regulation of response to reactive oxygen species namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "activation of response to AOS" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "activation of response to ROI" EXACT [GOC:TermGenie] synonym: "activation of response to ROS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000302 ! response to reactive oxygen species relationship: positively_regulates GO:0000302 ! response to reactive oxygen species created_by: kmv creation_date: 2012-06-20T07:47:35Z [Term] id: GO:1901034 name: regulation of L-glutamine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie] synonym: "regulation of L-glutamine import" BROAD [] synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2000485 ! regulation of glutamine transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: regulates GO:1903803 ! L-glutamine import across plasma membrane created_by: al creation_date: 2012-06-21T07:31:27Z [Term] id: GO:1901035 name: negative regulation of L-glutamine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import into a cell." [GOC:TermGenie] synonym: "down regulation of L-glutamine import" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamine import" BROAD [GOC:TermGenie] synonym: "down-regulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamine import" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "inhibition of L-glutamine import" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "negative regulation of L-glutamine import" BROAD [] synonym: "negative regulation of L-glutamine uptake" EXACT [GOC:TermGenie] is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2000486 ! negative regulation of glutamine transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane created_by: al creation_date: 2012-06-21T07:31:48Z [Term] id: GO:1901036 name: positive regulation of L-glutamine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie] synonym: "activation of L-glutamine import" NARROW [GOC:TermGenie] synonym: "activation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "positive regulation of L-glutamine import" BROAD [] synonym: "positive regulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamine import" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamine import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamine uptake" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamine import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamine uptake" EXACT [GOC:TermGenie] is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2000487 ! positive regulation of glutamine transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane created_by: al creation_date: 2012-06-21T07:31:56Z [Term] id: GO:1901037 name: obsolete regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed during the M/G1 transition of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:12411492] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "global transcription regulation from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of transcription during M/G1 transition of mitotic cell cycle" BROAD [] synonym: "regulation of transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter involved in M/G1 transition of mitotic cell cycle" RELATED [] is_obsolete: true created_by: pr creation_date: 2012-06-21T10:09:51Z [Term] id: GO:1901038 name: cyanidin 3-O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside." [GOC:TermGenie, PMID:21899608] synonym: "cyanidin 3-O-beta-D-glucoside metabolic process" EXACT [] synonym: "cyanidin 3-O-beta-D-glucoside metabolism" EXACT [GOC:TermGenie] is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: tb creation_date: 2012-06-22T12:16:26Z [Term] id: GO:1901039 name: regulation of peptide antigen transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046968 ! peptide antigen transport relationship: regulates GO:0046968 ! peptide antigen transport created_by: bf creation_date: 2012-06-22T04:07:56Z [Term] id: GO:1901040 name: negative regulation of peptide antigen transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie, PMID:16691491] synonym: "down regulation of peptide antigen transport" EXACT [GOC:TermGenie] synonym: "down-regulation of peptide antigen transport" EXACT [GOC:TermGenie] synonym: "downregulation of peptide antigen transport" EXACT [GOC:TermGenie] synonym: "inhibition of peptide antigen transport" NARROW [GOC:TermGenie] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0051051 ! negative regulation of transport is_a: GO:1901039 ! regulation of peptide antigen transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046968 ! peptide antigen transport relationship: negatively_regulates GO:0046968 ! peptide antigen transport created_by: bf creation_date: 2012-06-22T04:08:18Z [Term] id: GO:1901041 name: positive regulation of peptide antigen transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie] synonym: "activation of peptide antigen transport" NARROW [GOC:TermGenie] synonym: "up regulation of peptide antigen transport" EXACT [GOC:TermGenie] synonym: "up-regulation of peptide antigen transport" EXACT [GOC:TermGenie] synonym: "upregulation of peptide antigen transport" EXACT [GOC:TermGenie] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0051050 ! positive regulation of transport is_a: GO:1901039 ! regulation of peptide antigen transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046968 ! peptide antigen transport relationship: positively_regulates GO:0046968 ! peptide antigen transport created_by: bf creation_date: 2012-06-22T04:08:26Z [Term] id: GO:1901043 name: obsolete protein polyubiquitination involved in cellular response to misfolded protein namespace: biological_process def: "OBSOLETE. Any protein polyubiquitination that is involved in cellular response to misfolded protein." [GOC:al, GOC:TermGenie, PMID:21324894] comment: This term was made obsolete because it was added in error and a more specific term was created. synonym: "polyubiquitin of cellular response to misfolded protein" RELATED [GOC:TermGenie] synonym: "protein polyubiquitination involved in cellular response to misfolded protein" EXACT [] synonym: "protein polyubiquitination of cellular response to misfolded protein" EXACT [GOC:TermGenie] synonym: "protein polyubiquitinylation of cellular response to misfolded protein" EXACT [GOC:TermGenie] synonym: "protein polyubiquitylation of cellular response to misfolded protein" EXACT [GOC:TermGenie] is_obsolete: true consider: GO:1901044 created_by: al creation_date: 2012-06-26T09:40:45Z [Term] id: GO:1901044 name: protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process." [GOC:al, GOC:TermGenie, PMID:21324894] is_a: GO:0000209 ! protein polyubiquitination intersection_of: GO:0000209 ! protein polyubiquitination intersection_of: part_of GO:0071630 ! nuclear protein quality control by the ubiquitin-proteasome system relationship: part_of GO:0071630 ! nuclear protein quality control by the ubiquitin-proteasome system created_by: al creation_date: 2012-06-26T10:59:04Z [Term] id: GO:1901045 name: negative regulation of oviposition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of egg laying" BROAD [GOC:TermGenie] synonym: "down regulation of egg-laying" BROAD [GOC:TermGenie] synonym: "down regulation of oviposition" EXACT [GOC:TermGenie] synonym: "down-regulation of egg laying" BROAD [GOC:TermGenie] synonym: "down-regulation of egg-laying" BROAD [GOC:TermGenie] synonym: "down-regulation of oviposition" EXACT [GOC:TermGenie] synonym: "downregulation of egg laying" BROAD [GOC:TermGenie] synonym: "downregulation of egg-laying" BROAD [GOC:TermGenie] synonym: "downregulation of oviposition" EXACT [GOC:TermGenie] synonym: "inhibition of egg laying" BROAD [GOC:TermGenie] synonym: "inhibition of egg-laying" BROAD [GOC:TermGenie] synonym: "inhibition of oviposition" NARROW [GOC:TermGenie] synonym: "negative regulation of egg laying" BROAD [GOC:TermGenie] synonym: "negative regulation of egg-laying" BROAD [GOC:TermGenie] is_a: GO:0046662 ! regulation of oviposition is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018991 ! oviposition relationship: negatively_regulates GO:0018991 ! oviposition created_by: kmv creation_date: 2012-06-27T06:19:58Z [Term] id: GO:1901046 name: positive regulation of oviposition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie] synonym: "activation of egg laying" BROAD [GOC:TermGenie] synonym: "activation of egg-laying" BROAD [GOC:TermGenie] synonym: "activation of oviposition" NARROW [GOC:TermGenie] synonym: "positive regulation of egg laying" BROAD [GOC:TermGenie] synonym: "positive regulation of egg-laying" BROAD [GOC:TermGenie] synonym: "up regulation of egg laying" BROAD [GOC:TermGenie] synonym: "up regulation of egg-laying" BROAD [GOC:TermGenie] synonym: "up regulation of oviposition" EXACT [GOC:TermGenie] synonym: "up-regulation of egg laying" BROAD [GOC:TermGenie] synonym: "up-regulation of egg-laying" BROAD [GOC:TermGenie] synonym: "up-regulation of oviposition" EXACT [GOC:TermGenie] synonym: "upregulation of egg laying" BROAD [GOC:TermGenie] synonym: "upregulation of egg-laying" BROAD [GOC:TermGenie] synonym: "upregulation of oviposition" EXACT [GOC:TermGenie] is_a: GO:0046662 ! regulation of oviposition is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018991 ! oviposition relationship: positively_regulates GO:0018991 ! oviposition created_by: kmv creation_date: 2012-06-27T06:20:20Z [Term] id: GO:1901047 name: insulin receptor signaling pathway involved in determination of adult lifespan namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin that controls viability and duration in the adult phase of the life-cycle." [GOC:kmv, GOC:TermGenie, PMID:9360933] synonym: "daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] is_a: GO:0008286 ! insulin receptor signaling pathway intersection_of: GO:0008286 ! insulin receptor signaling pathway intersection_of: part_of GO:0008340 ! determination of adult lifespan relationship: part_of GO:0008340 ! determination of adult lifespan created_by: kmv creation_date: 2012-06-27T06:55:18Z [Term] id: GO:1901048 name: transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:kmv, GOC:TermGenie, PMID:9847239] synonym: "TGF-beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0040014 ! regulation of multicellular organism growth relationship: part_of GO:0040014 ! regulation of multicellular organism growth created_by: kmv creation_date: 2012-06-27T07:37:22Z [Term] id: GO:1901049 name: atropine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] synonym: "atropine metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process created_by: yaf creation_date: 2012-06-28T04:51:25Z [Term] id: GO:1901050 name: atropine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] synonym: "atropine breakdown" EXACT [GOC:TermGenie] synonym: "atropine catabolism" EXACT [GOC:TermGenie] synonym: "atropine degradation" EXACT [GOC:TermGenie] is_a: GO:0042737 ! drug catabolic process is_a: GO:1901049 ! atropine metabolic process created_by: yaf creation_date: 2012-06-28T04:51:51Z [Term] id: GO:1901051 name: atropine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] synonym: "atropine anabolism" EXACT [GOC:TermGenie] synonym: "atropine biosynthesis" EXACT [GOC:TermGenie] synonym: "atropine formation" EXACT [GOC:TermGenie] synonym: "atropine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901049 ! atropine metabolic process created_by: yaf creation_date: 2012-06-28T04:51:59Z [Term] id: GO:1901052 name: sarcosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] synonym: "sarcosine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: yaf creation_date: 2012-06-28T04:52:04Z [Term] id: GO:1901053 name: sarcosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] synonym: "sarcosine breakdown" EXACT [GOC:TermGenie] synonym: "sarcosine catabolism" EXACT [GOC:TermGenie] synonym: "sarcosine degradation" EXACT [GOC:TermGenie] is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:1901052 ! sarcosine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process created_by: yaf creation_date: 2012-06-28T04:52:29Z [Term] id: GO:1901054 name: sarcosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] synonym: "sarcosine anabolism" EXACT [GOC:TermGenie] synonym: "sarcosine biosynthesis" EXACT [GOC:TermGenie] synonym: "sarcosine formation" EXACT [GOC:TermGenie] synonym: "sarcosine synthesis" EXACT [GOC:TermGenie] is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:1901052 ! sarcosine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process created_by: yaf creation_date: 2012-06-28T04:52:37Z [Term] id: GO:1901055 name: trimethylenediamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] synonym: "trimethylenediamine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: yaf creation_date: 2012-06-28T04:52:42Z [Term] id: GO:1901056 name: trimethylenediamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] synonym: "trimethylenediamine breakdown" EXACT [GOC:TermGenie] synonym: "trimethylenediamine catabolism" EXACT [GOC:TermGenie] synonym: "trimethylenediamine degradation" EXACT [GOC:TermGenie] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:1901055 ! trimethylenediamine metabolic process created_by: yaf creation_date: 2012-06-28T04:53:06Z [Term] id: GO:1901057 name: trimethylenediamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] synonym: "trimethylenediamine anabolism" EXACT [GOC:TermGenie] synonym: "trimethylenediamine biosynthesis" EXACT [GOC:TermGenie] synonym: "trimethylenediamine formation" EXACT [GOC:TermGenie] synonym: "trimethylenediamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:1901055 ! trimethylenediamine metabolic process created_by: yaf creation_date: 2012-06-28T04:53:14Z [Term] id: GO:1901058 name: p-hydroxyphenyl lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "H-lignin metabolic process" EXACT [GOC:mengo_curators] synonym: "p-hydroxyphenyl lignin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009808 ! lignin metabolic process created_by: tt creation_date: 2012-06-29T12:31:57Z [Term] id: GO:1901059 name: p-hydroxyphenyl lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "H-lignin catabolic process" EXACT [GOC:mengo_curators] synonym: "p-hydroxyphenyl lignin breakdown" EXACT [GOC:TermGenie] synonym: "p-hydroxyphenyl lignin catabolism" EXACT [GOC:TermGenie] synonym: "p-hydroxyphenyl lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0046274 ! lignin catabolic process is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process created_by: tt creation_date: 2012-06-29T12:32:17Z [Term] id: GO:1901060 name: p-hydroxyphenyl lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "H-lignin biosynthetic process" EXACT [GOC:mengo_curators] synonym: "p-hydroxyphenyl lignin anabolism" EXACT [GOC:TermGenie] synonym: "p-hydroxyphenyl lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "p-hydroxyphenyl lignin formation" EXACT [GOC:TermGenie] synonym: "p-hydroxyphenyl lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009809 ! lignin biosynthetic process is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process created_by: tt creation_date: 2012-06-29T02:42:36Z [Term] id: GO:1901061 name: guaiacyl lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "G-lignin metabolic process" EXACT [GOC:mengo_curators] synonym: "guaiacyl lignin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009808 ! lignin metabolic process created_by: tt creation_date: 2012-06-29T02:46:39Z [Term] id: GO:1901062 name: guaiacyl lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "G-lignin catabolic process" EXACT [GOC:mengo_curators] synonym: "guaiacyl lignin breakdown" EXACT [GOC:TermGenie] synonym: "guaiacyl lignin catabolism" EXACT [GOC:TermGenie] synonym: "guaiacyl lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0046274 ! lignin catabolic process is_a: GO:1901061 ! guaiacyl lignin metabolic process created_by: tt creation_date: 2012-06-29T02:47:03Z [Term] id: GO:1901063 name: guaiacyl lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "G-lignin biosynthetic process" EXACT [GOC:mengo_curators] synonym: "guaiacyl lignin anabolism" EXACT [GOC:TermGenie] synonym: "guaiacyl lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "guaiacyl lignin formation" EXACT [GOC:TermGenie] synonym: "guaiacyl lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009809 ! lignin biosynthetic process is_a: GO:1901061 ! guaiacyl lignin metabolic process created_by: tt creation_date: 2012-06-29T03:29:53Z [Term] id: GO:1901064 name: syringal lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving syringal lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "S-lignin metabolic process" EXACT [GOC:mengo_curators] synonym: "syringal lignin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009808 ! lignin metabolic process created_by: tt creation_date: 2012-06-29T03:48:11Z [Term] id: GO:1901065 name: syringal lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of syringal lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "S-lignin catabolic process" EXACT [GOC:mengo_curators] synonym: "syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "syringal lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0046274 ! lignin catabolic process is_a: GO:1901064 ! syringal lignin metabolic process created_by: tt creation_date: 2012-06-29T03:48:33Z [Term] id: GO:1901066 name: syringal lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of syringal lignin." [GOC:mengo_curators, GOC:TermGenie] synonym: "S-lignin biosynthetic process" EXACT [GOC:mengo_curators] synonym: "syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "syringal lignin formation" EXACT [GOC:TermGenie] synonym: "syringal lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009809 ! lignin biosynthetic process is_a: GO:1901064 ! syringal lignin metabolic process created_by: tt creation_date: 2012-06-29T03:48:41Z [Term] id: GO:1901067 name: ferulate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ferulate." [GOC:mengo_curators, GOC:TermGenie] synonym: "ferulate breakdown" EXACT [GOC:TermGenie] synonym: "ferulate catabolism" EXACT [GOC:TermGenie] synonym: "ferulate degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0033494 ! ferulate metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901502 ! ether catabolic process created_by: tt creation_date: 2012-06-29T08:06:37Z [Term] id: GO:1901068 name: guanosine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanosine-containing compounds (guanosines)." [GOC:TermGenie] synonym: "guanosine-containing compound metabolism" EXACT [GOC:bf] synonym: "guanosines metabolic process" EXACT [CHEBI:24458] synonym: "guanosines metabolism" EXACT [GOC:TermGenie] is_a: GO:0046128 ! purine ribonucleoside metabolic process created_by: bf creation_date: 2012-07-02T01:51:37Z [Term] id: GO:1901069 name: guanosine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie] synonym: "guanosine-containing compound breakdown" EXACT [GOC:bf] synonym: "guanosine-containing compound catabolism" EXACT [GOC:bf] synonym: "guanosine-containing compound degradation" EXACT [GOC:bf] synonym: "guanosines breakdown" EXACT [GOC:TermGenie] synonym: "guanosines catabolic process" EXACT [CHEBI:24458] synonym: "guanosines catabolism" EXACT [GOC:TermGenie] synonym: "guanosines degradation" EXACT [GOC:TermGenie] is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process created_by: bf creation_date: 2012-07-02T01:52:00Z [Term] id: GO:1901070 name: guanosine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines)." [GOC:TermGenie] synonym: "guanosine-containing compound anabolism" EXACT [GOC:bf] synonym: "guanosine-containing compound biosynthesis" EXACT [GOC:bf] synonym: "guanosine-containing compound formation" EXACT [GOC:bf] synonym: "guanosine-containing compound synthesis" EXACT [GOC:bf] synonym: "guanosines anabolism" EXACT [GOC:TermGenie] synonym: "guanosines biosynthesis" EXACT [GOC:TermGenie] synonym: "guanosines biosynthetic process" EXACT [CHEBI:24458] synonym: "guanosines formation" EXACT [GOC:TermGenie] synonym: "guanosines synthesis" EXACT [GOC:TermGenie] is_a: GO:0046129 ! purine ribonucleoside biosynthetic process is_a: GO:1901068 ! guanosine-containing compound metabolic process created_by: bf creation_date: 2012-07-02T01:52:09Z [Term] id: GO:1901071 name: glucosamine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] synonym: "glucosamine-containing compound metabolism" EXACT [GOC:bf] synonym: "glucosamines metabolic process" EXACT [CHEBI:24271] synonym: "glucosamines metabolism" EXACT [GOC:TermGenie] is_a: GO:0006040 ! amino sugar metabolic process created_by: bf creation_date: 2012-07-02T03:18:04Z [Term] id: GO:1901072 name: glucosamine-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] synonym: "glucosamine-containing compound breakdown" EXACT [GOC:bf] synonym: "glucosamine-containing compound catabolism" EXACT [GOC:bf] synonym: "glucosamine-containing compound degradation" EXACT [GOC:bf] synonym: "glucosamines breakdown" EXACT [GOC:TermGenie] synonym: "glucosamines catabolic process" EXACT [CHEBI:24271] synonym: "glucosamines catabolism" EXACT [GOC:TermGenie] synonym: "glucosamines degradation" EXACT [GOC:TermGenie] is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:1901071 ! glucosamine-containing compound metabolic process created_by: bf creation_date: 2012-07-02T03:18:25Z [Term] id: GO:1901073 name: glucosamine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] synonym: "glucosamine-containing compound anabolism" EXACT [GOC:bf] synonym: "glucosamine-containing compound biosynthesis" EXACT [GOC:bf] synonym: "glucosamine-containing compound formation" EXACT [GOC:bf] synonym: "glucosamine-containing compound synthesis" EXACT [GOC:bf] synonym: "glucosamines anabolism" EXACT [GOC:TermGenie] synonym: "glucosamines biosynthesis" EXACT [GOC:TermGenie] synonym: "glucosamines biosynthetic process" EXACT [CHEBI:24271] synonym: "glucosamines formation" EXACT [GOC:TermGenie] synonym: "glucosamines synthesis" EXACT [GOC:TermGenie] is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:1901071 ! glucosamine-containing compound metabolic process created_by: bf creation_date: 2012-07-02T03:18:33Z [Term] id: GO:1901074 name: regulation of engulfment of apoptotic cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] synonym: "regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] is_a: GO:0060099 ! regulation of phagocytosis, engulfment is_a: GO:2000425 ! regulation of apoptotic cell clearance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043652 ! engulfment of apoptotic cell relationship: regulates GO:0043652 ! engulfment of apoptotic cell created_by: kmv creation_date: 2012-07-02T07:32:21Z [Term] id: GO:1901075 name: negative regulation of engulfment of apoptotic cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] synonym: "down regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "down regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "down regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "down-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "down-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "down-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "downregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "downregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "downregulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "inhibition of engulfment of apoptotic cell" NARROW [GOC:TermGenie] synonym: "inhibition of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie] synonym: "inhibition of engulfment of cell corpse" NARROW [GOC:TermGenie] synonym: "negative regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "negative regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] is_a: GO:0060101 ! negative regulation of phagocytosis, engulfment is_a: GO:1901074 ! regulation of engulfment of apoptotic cell is_a: GO:2000426 ! negative regulation of apoptotic cell clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043652 ! engulfment of apoptotic cell relationship: negatively_regulates GO:0043652 ! engulfment of apoptotic cell created_by: kmv creation_date: 2012-07-02T07:32:43Z [Term] id: GO:1901076 name: positive regulation of engulfment of apoptotic cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] synonym: "activation of engulfment of apoptotic cell" NARROW [GOC:TermGenie] synonym: "activation of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie] synonym: "activation of engulfment of cell corpse" NARROW [GOC:TermGenie] synonym: "positive regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "positive regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "up regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "up regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "up regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "up-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "up-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "up-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] synonym: "upregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] synonym: "upregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] synonym: "upregulation of engulfment of cell corpse" EXACT [GOC:TermGenie] is_a: GO:0060100 ! positive regulation of phagocytosis, engulfment is_a: GO:1901074 ! regulation of engulfment of apoptotic cell is_a: GO:2000427 ! positive regulation of apoptotic cell clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043652 ! engulfment of apoptotic cell relationship: positively_regulates GO:0043652 ! engulfment of apoptotic cell created_by: kmv creation_date: 2012-07-02T07:32:51Z [Term] id: GO:1901077 name: regulation of relaxation of muscle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090075 ! relaxation of muscle relationship: regulates GO:0090075 ! relaxation of muscle created_by: jl creation_date: 2012-07-04T10:44:30Z [Term] id: GO:1901078 name: negative regulation of relaxation of muscle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] synonym: "down regulation of relaxation of muscle" EXACT [GOC:TermGenie] synonym: "down-regulation of relaxation of muscle" EXACT [GOC:TermGenie] synonym: "downregulation of relaxation of muscle" EXACT [GOC:TermGenie] synonym: "inhibition of relaxation of muscle" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901077 ! regulation of relaxation of muscle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090075 ! relaxation of muscle relationship: negatively_regulates GO:0090075 ! relaxation of muscle created_by: jl creation_date: 2012-07-04T10:44:54Z [Term] id: GO:1901079 name: positive regulation of relaxation of muscle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] synonym: "activation of relaxation of muscle" NARROW [GOC:TermGenie] synonym: "up regulation of relaxation of muscle" EXACT [GOC:TermGenie] synonym: "up-regulation of relaxation of muscle" EXACT [GOC:TermGenie] synonym: "upregulation of relaxation of muscle" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901077 ! regulation of relaxation of muscle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090075 ! relaxation of muscle relationship: positively_regulates GO:0090075 ! relaxation of muscle created_by: jl creation_date: 2012-07-04T10:45:02Z [Term] id: GO:1901080 name: regulation of relaxation of smooth muscle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] synonym: "regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] is_a: GO:1901077 ! regulation of relaxation of muscle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044557 ! relaxation of smooth muscle relationship: regulates GO:0044557 ! relaxation of smooth muscle created_by: jl creation_date: 2012-07-04T10:45:09Z [Term] id: GO:1901081 name: negative regulation of relaxation of smooth muscle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] synonym: "down regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "down regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "down-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "downregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "inhibition of relaxation of smooth muscle" NARROW [GOC:TermGenie] synonym: "inhibition of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "negative regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] is_a: GO:1901078 ! negative regulation of relaxation of muscle is_a: GO:1901080 ! regulation of relaxation of smooth muscle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044557 ! relaxation of smooth muscle relationship: negatively_regulates GO:0044557 ! relaxation of smooth muscle created_by: jl creation_date: 2012-07-04T10:45:31Z [Term] id: GO:1901082 name: positive regulation of relaxation of smooth muscle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] synonym: "activation of relaxation of smooth muscle" NARROW [GOC:TermGenie] synonym: "activation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "positive regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "up regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "up regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "up-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] synonym: "upregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle relaxation" EXACT [GOC:TermGenie] is_a: GO:1901079 ! positive regulation of relaxation of muscle is_a: GO:1901080 ! regulation of relaxation of smooth muscle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044557 ! relaxation of smooth muscle relationship: positively_regulates GO:0044557 ! relaxation of smooth muscle created_by: jl creation_date: 2012-07-04T10:45:39Z [Term] id: GO:1901083 name: pyrrolizidine alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] synonym: "pyrrolizidine alkaloid metabolism" EXACT [GOC:TermGenie] is_a: GO:0009820 ! alkaloid metabolic process created_by: yaf creation_date: 2012-07-05T10:27:56Z [Term] id: GO:1901084 name: pyrrolizidine alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] synonym: "pyrrolizidine alkaloid breakdown" EXACT [GOC:TermGenie] synonym: "pyrrolizidine alkaloid catabolism" EXACT [GOC:TermGenie] synonym: "pyrrolizidine alkaloid degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process created_by: yaf creation_date: 2012-07-05T10:28:20Z [Term] id: GO:1901085 name: pyrrolizidine alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] synonym: "pyrrolizidine alkaloid anabolism" EXACT [GOC:TermGenie] synonym: "pyrrolizidine alkaloid biosynthesis" EXACT [GOC:TermGenie] synonym: "pyrrolizidine alkaloid formation" EXACT [GOC:TermGenie] synonym: "pyrrolizidine alkaloid synthesis" EXACT [GOC:TermGenie] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process created_by: yaf creation_date: 2012-07-05T10:28:28Z [Term] id: GO:1901086 name: benzylpenicillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] synonym: "benzylpenicillin metabolism" EXACT [GOC:TermGenie] synonym: "penicillin G metabolism" EXACT [] is_a: GO:0042316 ! penicillin metabolic process created_by: yaf creation_date: 2012-07-05T10:28:33Z [Term] id: GO:1901087 name: benzylpenicillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] synonym: "benzylpenicillin breakdown" EXACT [GOC:TermGenie] synonym: "benzylpenicillin catabolism" EXACT [GOC:TermGenie] synonym: "benzylpenicillin degradation" EXACT [GOC:TermGenie] synonym: "penicillin G breakdown" EXACT [] synonym: "penicillin G catabolic process" EXACT [] synonym: "penicillin G catabolism" EXACT [] synonym: "penicillin G degradation" EXACT [] is_a: GO:0042317 ! penicillin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901086 ! benzylpenicillin metabolic process created_by: yaf creation_date: 2012-07-05T10:28:59Z [Term] id: GO:1901088 name: benzylpenicillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] synonym: "benzylpenicillin anabolism" EXACT [GOC:TermGenie] synonym: "benzylpenicillin biosynthesis" EXACT [GOC:TermGenie] synonym: "benzylpenicillin formation" EXACT [GOC:TermGenie] synonym: "benzylpenicillin synthesis" EXACT [GOC:TermGenie] synonym: "penicillin G anabolism" EXACT [GOC:yaf] synonym: "penicillin G biosynthesis" EXACT [GOC:yaf] synonym: "penicillin G formation" EXACT [GOC:yaf] synonym: "penicillin G synthesis" EXACT [GOC:yaf] is_a: GO:0042318 ! penicillin biosynthetic process is_a: GO:1901086 ! benzylpenicillin metabolic process created_by: yaf creation_date: 2012-07-05T10:29:07Z [Term] id: GO:1901089 name: acetate ester metabolic process involved in fermentation namespace: biological_process def: "Any acetate ester metabolic process that is involved in fermentation." [GOC:sgd_curators, GOC:TermGenie] synonym: "acetate ester metabolic process during fermentation" EXACT [GOC:sgd_curators] is_a: GO:1900619 ! acetate ester metabolic process intersection_of: GO:1900619 ! acetate ester metabolic process intersection_of: part_of GO:0006113 ! fermentation relationship: part_of GO:0006113 ! fermentation created_by: ramab creation_date: 2012-07-05T11:47:17Z [Term] id: GO:1901090 name: regulation of protein tetramerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] synonym: "regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of protein tetramer formation" EXACT [GOC:TermGenie] is_a: GO:0032459 ! regulation of protein oligomerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051262 ! protein tetramerization relationship: regulates GO:0051262 ! protein tetramerization created_by: pm creation_date: 2012-07-06T12:51:00Z [Term] id: GO:1901091 name: negative regulation of protein tetramerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] synonym: "down regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "down regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "down regulation of protein tetramerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tetramerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "downregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "downregulation of protein tetramerization" EXACT [GOC:TermGenie] synonym: "inhibition of protein tetramer assembly" NARROW [GOC:TermGenie] synonym: "inhibition of protein tetramer biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of protein tetramer biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of protein tetramer formation" NARROW [GOC:TermGenie] synonym: "inhibition of protein tetramerization" NARROW [GOC:TermGenie] synonym: "negative regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein tetramer formation" EXACT [GOC:TermGenie] is_a: GO:0032460 ! negative regulation of protein oligomerization is_a: GO:1901090 ! regulation of protein tetramerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051262 ! protein tetramerization relationship: negatively_regulates GO:0051262 ! protein tetramerization created_by: pm creation_date: 2012-07-06T12:51:24Z [Term] id: GO:1901092 name: positive regulation of protein tetramerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] synonym: "activation of protein tetramer assembly" NARROW [GOC:TermGenie] synonym: "activation of protein tetramer biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of protein tetramer biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of protein tetramer formation" NARROW [GOC:TermGenie] synonym: "activation of protein tetramerization" NARROW [GOC:TermGenie] synonym: "positive regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "up regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "up regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "up regulation of protein tetramerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tetramerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein tetramer assembly" EXACT [GOC:TermGenie] synonym: "upregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein tetramer formation" EXACT [GOC:TermGenie] synonym: "upregulation of protein tetramerization" EXACT [GOC:TermGenie] is_a: GO:0032461 ! positive regulation of protein oligomerization is_a: GO:1901090 ! regulation of protein tetramerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051262 ! protein tetramerization relationship: positively_regulates GO:0051262 ! protein tetramerization created_by: pm creation_date: 2012-07-06T12:51:32Z [Term] id: GO:1901093 name: regulation of protein homotetramerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] synonym: "regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of protein homotetramer formation" EXACT [GOC:TermGenie] is_a: GO:0032462 ! regulation of protein homooligomerization is_a: GO:1901090 ! regulation of protein tetramerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051289 ! protein homotetramerization relationship: regulates GO:0051289 ! protein homotetramerization created_by: pm creation_date: 2012-07-06T12:57:33Z [Term] id: GO:1901094 name: negative regulation of protein homotetramerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] synonym: "down regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "down regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "down regulation of protein homotetramerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein homotetramerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "downregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "downregulation of protein homotetramerization" EXACT [GOC:TermGenie] synonym: "inhibition of protein homotetramer assembly" NARROW [GOC:TermGenie] synonym: "inhibition of protein homotetramer biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of protein homotetramer formation" NARROW [GOC:TermGenie] synonym: "inhibition of protein homotetramerization" NARROW [GOC:TermGenie] synonym: "negative regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein homotetramer formation" EXACT [GOC:TermGenie] is_a: GO:0032463 ! negative regulation of protein homooligomerization is_a: GO:1901091 ! negative regulation of protein tetramerization is_a: GO:1901093 ! regulation of protein homotetramerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051289 ! protein homotetramerization relationship: negatively_regulates GO:0051289 ! protein homotetramerization created_by: pm creation_date: 2012-07-06T12:57:58Z [Term] id: GO:1901095 name: positive regulation of protein homotetramerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] synonym: "activation of protein homotetramer assembly" NARROW [GOC:TermGenie] synonym: "activation of protein homotetramer biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of protein homotetramer formation" NARROW [GOC:TermGenie] synonym: "activation of protein homotetramerization" NARROW [GOC:TermGenie] synonym: "positive regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "up regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "up regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "up regulation of protein homotetramerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein homotetramerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein homotetramer assembly" EXACT [GOC:TermGenie] synonym: "upregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein homotetramer formation" EXACT [GOC:TermGenie] synonym: "upregulation of protein homotetramerization" EXACT [GOC:TermGenie] is_a: GO:0032464 ! positive regulation of protein homooligomerization is_a: GO:1901092 ! positive regulation of protein tetramerization is_a: GO:1901093 ! regulation of protein homotetramerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051289 ! protein homotetramerization relationship: positively_regulates GO:0051289 ! protein homotetramerization created_by: pm creation_date: 2012-07-06T12:58:06Z [Term] id: GO:1901096 name: regulation of autophagosome maturation namespace: biological_process alt_id: GO:1902452 def: "Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] synonym: "regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] synonym: "regulation of autophagosome fusion" EXACT [] synonym: "regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097352 ! autophagosome maturation relationship: regulates GO:0097352 ! autophagosome maturation created_by: lb creation_date: 2012-07-10T07:22:01Z [Term] id: GO:1901097 name: negative regulation of autophagosome maturation namespace: biological_process alt_id: GO:1902453 def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] synonym: "down regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "down regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "down regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "down regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "down regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "down regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "down-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "down-regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "downregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "downregulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "downregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "downregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "downregulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "downregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "inhibition of autolysosome formation" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole fusion" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole maturation" NARROW [GOC:TermGenie] synonym: "inhibition of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "inhibition of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "negative regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "negative regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "negative regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] synonym: "negative regulation of autophagosome fusion" EXACT [] synonym: "negative regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "negative regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:1901096 ! regulation of autophagosome maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097352 ! autophagosome maturation relationship: negatively_regulates GO:0097352 ! autophagosome maturation created_by: lb creation_date: 2012-07-10T07:22:26Z [Term] id: GO:1901098 name: positive regulation of autophagosome maturation namespace: biological_process alt_id: GO:1902454 def: "Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] synonym: "activation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "activation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "activation of autophagic vacuole fusion" NARROW [GOC:TermGenie] synonym: "activation of autophagic vacuole maturation" NARROW [GOC:TermGenie] synonym: "activation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "activation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "positive regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "positive regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "positive regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] synonym: "positive regulation of autophagosome fusion" EXACT [] synonym: "positive regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "positive regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "up regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "up regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "up regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "up regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "up regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "up regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "up-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "up-regulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "up-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] synonym: "upregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] synonym: "upregulation of autolysosome formation" NARROW [GOC:TermGenie] synonym: "upregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] synonym: "upregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] synonym: "upregulation of autophagosome maturation" EXACT [GOC:TermGenie] synonym: "upregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:1901096 ! regulation of autophagosome maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097352 ! autophagosome maturation relationship: positively_regulates GO:0097352 ! autophagosome maturation created_by: lb creation_date: 2012-07-10T07:22:34Z [Term] id: GO:1901099 name: negative regulation of signal transduction in absence of ligand namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie] synonym: "down regulation of basal signaling" NARROW [GOC:TermGenie] synonym: "down regulation of non-classical signal transduction" BROAD [GOC:TermGenie] synonym: "down regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] synonym: "down regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] synonym: "down-regulation of basal signaling" NARROW [GOC:TermGenie] synonym: "down-regulation of non-classical signal transduction" BROAD [GOC:TermGenie] synonym: "down-regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] synonym: "downregulation of basal signaling" NARROW [GOC:TermGenie] synonym: "downregulation of non-classical signal transduction" BROAD [GOC:TermGenie] synonym: "downregulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] synonym: "inhibition of signal transduction in absence of ligand" NARROW [GOC:TermGenie] synonym: "negative regulation of non-classical signal transduction" BROAD [GOC:TermGenie] synonym: "negative regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038034 ! signal transduction in absence of ligand relationship: negatively_regulates GO:0038034 ! signal transduction in absence of ligand created_by: al creation_date: 2012-07-10T10:31:08Z [Term] id: GO:1901101 name: gramicidin S metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] synonym: "gramicidin S metabolism" EXACT [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process created_by: yaf creation_date: 2012-07-11T02:30:26Z [Term] id: GO:1901102 name: gramicidin S catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] synonym: "gramicidin S breakdown" EXACT [GOC:TermGenie] synonym: "gramicidin S catabolism" EXACT [GOC:TermGenie] synonym: "gramicidin S degradation" EXACT [GOC:TermGenie] is_a: GO:0043171 ! peptide catabolic process is_a: GO:1901101 ! gramicidin S metabolic process created_by: yaf creation_date: 2012-07-11T02:30:52Z [Term] id: GO:1901103 name: gramicidin S biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] synonym: "gramicidin S anabolism" EXACT [GOC:TermGenie] synonym: "gramicidin S biosynthesis" EXACT [GOC:TermGenie] synonym: "gramicidin S formation" EXACT [GOC:TermGenie] synonym: "gramicidin S synthesis" EXACT [GOC:TermGenie] is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:1901101 ! gramicidin S metabolic process created_by: yaf creation_date: 2012-07-11T02:31:00Z [Term] id: GO:1901104 name: tetracenomycin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: yaf creation_date: 2012-07-11T02:50:32Z [Term] id: GO:1901105 name: tetracenomycin C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie] synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie] synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1901104 ! tetracenomycin C metabolic process created_by: yaf creation_date: 2012-07-11T02:50:54Z [Term] id: GO:1901106 name: tetracenomycin C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie] synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie] synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie] synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901104 ! tetracenomycin C metabolic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process created_by: yaf creation_date: 2012-07-11T02:51:03Z [Term] id: GO:1901107 name: granaticin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] synonym: "granaticin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: yaf creation_date: 2012-07-11T02:51:08Z [Term] id: GO:1901108 name: granaticin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] synonym: "granaticin breakdown" EXACT [GOC:TermGenie] synonym: "granaticin catabolism" EXACT [GOC:TermGenie] synonym: "granaticin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901107 ! granaticin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901662 ! quinone catabolic process created_by: yaf creation_date: 2012-07-11T02:51:33Z [Term] id: GO:1901109 name: granaticin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] synonym: "granaticin anabolism" EXACT [GOC:TermGenie] synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie] synonym: "granaticin formation" EXACT [GOC:TermGenie] synonym: "granaticin synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:1901107 ! granaticin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process created_by: yaf creation_date: 2012-07-11T02:51:40Z [Term] id: GO:1901110 name: actinorhodin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: yaf creation_date: 2012-07-11T03:05:37Z [Term] id: GO:1901111 name: actinorhodin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie] synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie] synonym: "actinorhodin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901110 ! actinorhodin metabolic process is_a: GO:1901662 ! quinone catabolic process created_by: yaf creation_date: 2012-07-11T03:06:00Z [Term] id: GO:1901112 name: actinorhodin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie] synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie] synonym: "actinorhodin formation" EXACT [GOC:TermGenie] synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901110 ! actinorhodin metabolic process is_a: GO:1901663 ! quinone biosynthetic process created_by: yaf creation_date: 2012-07-11T03:06:08Z [Term] id: GO:1901113 name: erythromycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] synonym: "erythromycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0033067 ! macrolide metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: yaf creation_date: 2012-07-11T03:06:13Z [Term] id: GO:1901114 name: erythromycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] synonym: "erythromycin breakdown" EXACT [GOC:TermGenie] synonym: "erythromycin catabolism" EXACT [GOC:TermGenie] synonym: "erythromycin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901113 ! erythromycin metabolic process is_a: GO:1901335 ! lactone catabolic process created_by: yaf creation_date: 2012-07-11T03:06:38Z [Term] id: GO:1901115 name: erythromycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] synonym: "erythromycin anabolism" EXACT [GOC:TermGenie] synonym: "erythromycin biosynthesis" EXACT [GOC:TermGenie] synonym: "erythromycin formation" EXACT [GOC:TermGenie] synonym: "erythromycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0033068 ! macrolide biosynthetic process is_a: GO:1901113 ! erythromycin metabolic process created_by: yaf creation_date: 2012-07-11T03:06:46Z [Term] id: GO:1901116 name: cephamycin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] synonym: "cephamycin C metabolism" EXACT [GOC:TermGenie] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process created_by: yaf creation_date: 2012-07-11T03:06:51Z [Term] id: GO:1901117 name: cephamycin C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] synonym: "cephamycin C breakdown" EXACT [GOC:TermGenie] synonym: "cephamycin C catabolism" EXACT [GOC:TermGenie] synonym: "cephamycin C degradation" EXACT [GOC:TermGenie] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901116 ! cephamycin C metabolic process created_by: yaf creation_date: 2012-07-11T03:07:13Z [Term] id: GO:1901118 name: cephamycin C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] synonym: "cephamycin C anabolism" EXACT [GOC:TermGenie] synonym: "cephamycin C biosynthesis" EXACT [GOC:TermGenie] synonym: "cephamycin C formation" EXACT [GOC:TermGenie] synonym: "cephamycin C synthesis" EXACT [GOC:TermGenie] is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901116 ! cephamycin C metabolic process created_by: yaf creation_date: 2012-07-11T03:07:21Z [Term] id: GO:1901119 name: tobramycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] synonym: "tobramycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019751 ! polyol metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: yaf creation_date: 2012-07-11T03:15:19Z [Term] id: GO:1901120 name: tobramycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] synonym: "tobramycin breakdown" EXACT [GOC:TermGenie] synonym: "tobramycin catabolism" EXACT [GOC:TermGenie] synonym: "tobramycin degradation" EXACT [GOC:TermGenie] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1901119 ! tobramycin metabolic process created_by: yaf creation_date: 2012-07-11T03:15:43Z [Term] id: GO:1901121 name: tobramycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] synonym: "tobramycin anabolism" EXACT [GOC:TermGenie] synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie] synonym: "tobramycin formation" EXACT [GOC:TermGenie] synonym: "tobramycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901119 ! tobramycin metabolic process created_by: yaf creation_date: 2012-07-11T03:15:51Z [Term] id: GO:1901122 name: bacitracin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016999 ! antibiotic metabolic process created_by: yaf creation_date: 2012-07-11T03:15:56Z [Term] id: GO:1901123 name: bacitracin A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie] synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie] synonym: "bacitracin A degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:1901122 ! bacitracin A metabolic process created_by: yaf creation_date: 2012-07-11T03:16:20Z [Term] id: GO:1901124 name: bacitracin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie] synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie] synonym: "bacitracin A formation" EXACT [GOC:TermGenie] synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:1901122 ! bacitracin A metabolic process created_by: yaf creation_date: 2012-07-11T03:16:27Z [Term] id: GO:1901125 name: candicidin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] synonym: "candicidin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: yaf creation_date: 2012-07-11T03:16:32Z [Term] id: GO:1901126 name: candicidin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] synonym: "candicidin breakdown" EXACT [GOC:TermGenie] synonym: "candicidin catabolism" EXACT [GOC:TermGenie] synonym: "candicidin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901125 ! candicidin metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: yaf creation_date: 2012-07-11T03:16:54Z [Term] id: GO:1901127 name: candicidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] synonym: "candicidin anabolism" EXACT [GOC:TermGenie] synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie] synonym: "candicidin formation" EXACT [GOC:TermGenie] synonym: "candicidin synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:1901125 ! candicidin metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: yaf creation_date: 2012-07-11T03:17:02Z [Term] id: GO:1901128 name: gentamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] synonym: "gentamycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process created_by: yaf creation_date: 2012-07-11T03:26:25Z [Term] id: GO:1901129 name: gentamycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] synonym: "gentamycin breakdown" EXACT [GOC:TermGenie] synonym: "gentamycin catabolism" EXACT [GOC:TermGenie] synonym: "gentamycin degradation" EXACT [GOC:TermGenie] is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901128 ! gentamycin metabolic process created_by: yaf creation_date: 2012-07-11T03:26:51Z [Term] id: GO:1901130 name: gentamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] synonym: "gentamycin anabolism" EXACT [GOC:TermGenie] synonym: "gentamycin biosynthesis" EXACT [GOC:TermGenie] synonym: "gentamycin formation" EXACT [GOC:TermGenie] synonym: "gentamycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901128 ! gentamycin metabolic process created_by: yaf creation_date: 2012-07-11T03:26:59Z [Term] id: GO:1901131 name: kanamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] synonym: "kanamycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process created_by: yaf creation_date: 2012-07-11T03:27:04Z [Term] id: GO:1901132 name: kanamycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] synonym: "kanamycin breakdown" EXACT [GOC:TermGenie] synonym: "kanamycin catabolism" EXACT [GOC:TermGenie] synonym: "kanamycin degradation" EXACT [GOC:TermGenie] is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901131 ! kanamycin metabolic process created_by: yaf creation_date: 2012-07-11T03:27:24Z [Term] id: GO:1901133 name: kanamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] synonym: "kanamycin anabolism" EXACT [GOC:TermGenie] synonym: "kanamycin biosynthesis" EXACT [GOC:TermGenie] synonym: "kanamycin formation" EXACT [GOC:TermGenie] synonym: "kanamycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901131 ! kanamycin metabolic process created_by: yaf creation_date: 2012-07-11T03:27:32Z [Term] id: GO:1901134 name: negative regulation of coflocculation via protein-carbohydrate interaction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of coflocculation via protein-carbohydrate interaction." [GOC:TermGenie, PMID:11472912] synonym: "down regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie] synonym: "down regulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie] synonym: "down-regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie] synonym: "down-regulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie] synonym: "downregulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie] synonym: "downregulation of coflocculation via protein-carbohydrate interaction" EXACT [GOC:TermGenie] synonym: "inhibition of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie] synonym: "inhibition of coflocculation via protein-carbohydrate interaction" NARROW [GOC:TermGenie] synonym: "negative regulation of coflocculation via lectin-mannose interaction" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036282 ! coflocculation via protein-carbohydrate interaction relationship: negatively_regulates GO:0036282 ! coflocculation via protein-carbohydrate interaction created_by: al creation_date: 2012-07-12T07:17:11Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] subset: goslim_agr subset: goslim_mouse synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901136 name: carbohydrate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: bf creation_date: 2012-07-12T04:05:31Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901140 name: p-coumaryl alcohol transport namespace: biological_process def: "The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] synonym: "4-hydroxycinnamyl alcohol transport" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport created_by: tb creation_date: 2012-07-12T09:46:16Z [Term] id: GO:1901141 name: regulation of lignin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lignin biosynthetic process." [GOC:TermGenie] synonym: "regulation of lignin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of lignin formation" EXACT [GOC:TermGenie] synonym: "regulation of lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009809 ! lignin biosynthetic process relationship: regulates GO:0009809 ! lignin biosynthetic process created_by: tb creation_date: 2012-07-12T09:53:09Z [Term] id: GO:1901142 name: insulin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie] synonym: "insulin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019538 ! protein metabolic process created_by: pm creation_date: 2012-07-13T12:32:40Z [Term] id: GO:1901143 name: insulin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie] synonym: "insulin breakdown" EXACT [GOC:TermGenie] synonym: "insulin catabolism" EXACT [GOC:TermGenie] synonym: "insulin degradation" EXACT [GOC:TermGenie] is_a: GO:0030163 ! protein catabolic process is_a: GO:1901142 ! insulin metabolic process created_by: pm creation_date: 2012-07-13T12:33:03Z [Term] id: GO:1901144 name: obsolete insulin biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of insulin." [GOC:TermGenie] synonym: "insulin anabolism" EXACT [GOC:TermGenie] synonym: "insulin biosynthesis" EXACT [GOC:TermGenie] synonym: "insulin biosynthetic process" EXACT [] synonym: "insulin formation" EXACT [GOC:TermGenie] synonym: "insulin synthesis" EXACT [GOC:TermGenie] is_obsolete: true created_by: pm creation_date: 2012-07-13T12:33:10Z [Term] id: GO:1901145 name: mesenchymal cell apoptotic process involved in nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis is_a: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: part_of GO:0072028 ! nephron morphogenesis relationship: part_of GO:0072028 ! nephron morphogenesis created_by: pr creation_date: 2012-07-13T01:43:51Z [Term] id: GO:1901146 name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis created_by: pr creation_date: 2012-07-13T02:40:43Z [Term] id: GO:1901147 name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis namespace: biological_process def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis intersection_of: GO:0097152 ! mesenchymal cell apoptotic process intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: pr creation_date: 2012-07-13T02:41:12Z [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization namespace: biological_process def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] synonym: "extracellular matrix protein production" RELATED [GOC:pg] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: part_of GO:0030198 ! extracellular matrix organization relationship: part_of GO:0030198 ! extracellular matrix organization created_by: bf creation_date: 2012-07-16T03:29:30Z [Term] id: GO:1901149 name: salicylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with salicylic acid." [GOC:TermGenie, PMID:22699612] synonym: "salicylic acid receptor" NARROW [PMID:22699612] is_a: GO:0008144 ! drug binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0042562 ! hormone binding is_a: GO:0097159 ! organic cyclic compound binding created_by: dhl creation_date: 2012-07-16T05:26:38Z [Term] id: GO:1901150 name: vistamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] synonym: "ribostamycin metabolic process" EXACT [GOC:yaf] synonym: "ribostamycin metabolism" EXACT [GOC:yaf] synonym: "vistamycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process created_by: yaf creation_date: 2012-07-17T04:26:45Z [Term] id: GO:1901151 name: vistamycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] synonym: "ribostamycin breakdown" EXACT [GOC:yaf] synonym: "ribostamycin catabolic process" EXACT [GOC:yaf] synonym: "ribostamycin catabolism" EXACT [GOC:yaf] synonym: "ribostamycin degradation" EXACT [GOC:yaf] synonym: "vistamycin breakdown" EXACT [GOC:TermGenie] synonym: "vistamycin catabolism" EXACT [GOC:TermGenie] synonym: "vistamycin degradation" EXACT [GOC:TermGenie] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901150 ! vistamycin metabolic process created_by: yaf creation_date: 2012-07-17T04:27:07Z [Term] id: GO:1901152 name: vistamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] synonym: "ribostamycin anabolism" EXACT [GOC:yaf] synonym: "ribostamycin biosynthesis" EXACT [GOC:yaf] synonym: "ribostamycin biosynthetic process" EXACT [GOC:yaf] synonym: "ribostamycin formation" EXACT [GOC:yaf] synonym: "ribostamycin synthesis" EXACT [GOC:yaf] synonym: "vistamycin anabolism" EXACT [GOC:TermGenie] synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie] synonym: "vistamycin formation" EXACT [GOC:TermGenie] synonym: "vistamycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901150 ! vistamycin metabolic process created_by: yaf creation_date: 2012-07-17T04:27:15Z [Term] id: GO:1901153 name: paromomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] synonym: "paromomycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process created_by: yaf creation_date: 2012-07-17T04:27:20Z [Term] id: GO:1901154 name: paromomycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] synonym: "paromomycin breakdown" EXACT [GOC:TermGenie] synonym: "paromomycin catabolism" EXACT [GOC:TermGenie] synonym: "paromomycin degradation" EXACT [GOC:TermGenie] is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901153 ! paromomycin metabolic process created_by: yaf creation_date: 2012-07-17T04:27:44Z [Term] id: GO:1901155 name: paromomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] synonym: "paromomycin anabolism" EXACT [GOC:TermGenie] synonym: "paromomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "paromomycin formation" EXACT [GOC:TermGenie] synonym: "paromomycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901153 ! paromomycin metabolic process created_by: yaf creation_date: 2012-07-17T04:27:51Z [Term] id: GO:1901156 name: neomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] synonym: "neomycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process created_by: yaf creation_date: 2012-07-17T04:27:57Z [Term] id: GO:1901157 name: neomycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] synonym: "neomycin breakdown" EXACT [GOC:TermGenie] synonym: "neomycin catabolism" EXACT [GOC:TermGenie] synonym: "neomycin degradation" EXACT [GOC:TermGenie] is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901156 ! neomycin metabolic process created_by: yaf creation_date: 2012-07-17T04:28:20Z [Term] id: GO:1901158 name: neomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] synonym: "neomycin anabolism" EXACT [GOC:TermGenie] synonym: "neomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "neomycin formation" EXACT [GOC:TermGenie] synonym: "neomycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901156 ! neomycin metabolic process created_by: yaf creation_date: 2012-07-17T04:28:28Z [Term] id: GO:1901159 name: xylulose 5-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate." [GOC:bf, GOC:TermGenie] synonym: "xylulose 5-phosphate anabolism" EXACT [GOC:TermGenie] synonym: "xylulose 5-phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "xylulose 5-phosphate formation" EXACT [GOC:TermGenie] synonym: "xylulose 5-phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0051167 ! xylulose 5-phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process created_by: bf creation_date: 2012-07-18T04:42:24Z [Term] id: GO:1901160 name: primary amino compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie] synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: bf creation_date: 2012-07-18T04:44:39Z [Term] id: GO:1901161 name: primary amino compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901160 ! primary amino compound metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process created_by: bf creation_date: 2012-07-18T04:45:06Z [Term] id: GO:1901162 name: primary amino compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] synonym: "primary amino compound formation" EXACT [GOC:TermGenie] synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901160 ! primary amino compound metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: bf creation_date: 2012-07-18T04:45:14Z [Term] id: GO:1901163 name: regulation of trophoblast cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061450 ! trophoblast cell migration relationship: regulates GO:0061450 ! trophoblast cell migration created_by: vk creation_date: 2012-07-19T07:53:06Z [Term] id: GO:1901164 name: negative regulation of trophoblast cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061450 ! trophoblast cell migration relationship: negatively_regulates GO:0061450 ! trophoblast cell migration created_by: vk creation_date: 2012-07-19T07:53:28Z [Term] id: GO:1901165 name: positive regulation of trophoblast cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061450 ! trophoblast cell migration relationship: positively_regulates GO:0061450 ! trophoblast cell migration created_by: vk creation_date: 2012-07-19T07:53:35Z [Term] id: GO:1901166 name: neural crest cell migration involved in autonomic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie] is_a: GO:0001755 ! neural crest cell migration intersection_of: GO:0001755 ! neural crest cell migration intersection_of: part_of GO:0048483 ! autonomic nervous system development relationship: part_of GO:0048483 ! autonomic nervous system development created_by: vk creation_date: 2012-07-19T08:39:56Z [Term] id: GO:1901167 name: 3-chlorocatechol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] synonym: "3-chlorocatechol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: yaf creation_date: 2012-07-19T09:33:16Z [Term] id: GO:1901168 name: 3-chlorocatechol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] synonym: "3-chlorocatechol breakdown" EXACT [GOC:TermGenie] synonym: "3-chlorocatechol catabolism" EXACT [GOC:TermGenie] synonym: "3-chlorocatechol degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:1901167 ! 3-chlorocatechol metabolic process created_by: yaf creation_date: 2012-07-19T09:33:38Z [Term] id: GO:1901169 name: 3-chlorocatechol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] synonym: "3-chlorocatechol anabolism" EXACT [GOC:TermGenie] synonym: "3-chlorocatechol biosynthesis" EXACT [GOC:TermGenie] synonym: "3-chlorocatechol formation" EXACT [GOC:TermGenie] synonym: "3-chlorocatechol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:1901167 ! 3-chlorocatechol metabolic process created_by: yaf creation_date: 2012-07-19T09:33:45Z [Term] id: GO:1901170 name: naphthalene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082] synonym: "naphthalene breakdown" EXACT [GOC:TermGenie] synonym: "naphthalene catabolism" EXACT [GOC:TermGenie] synonym: "naphthalene degradation" EXACT [GOC:TermGenie] is_a: GO:0018931 ! naphthalene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: yaf creation_date: 2012-07-19T09:33:50Z [Term] id: GO:1901171 name: naphthalene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082] synonym: "naphthalene anabolism" EXACT [GOC:TermGenie] synonym: "naphthalene biosynthesis" EXACT [GOC:TermGenie] synonym: "naphthalene formation" EXACT [GOC:TermGenie] synonym: "naphthalene synthesis" EXACT [GOC:TermGenie] is_a: GO:0018931 ! naphthalene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: yaf creation_date: 2012-07-19T09:34:11Z [Term] id: GO:1901172 name: phytoene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] synonym: "phytoene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2012-07-19T09:47:46Z [Term] id: GO:1901173 name: phytoene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] synonym: "phytoene breakdown" EXACT [GOC:TermGenie] synonym: "phytoene catabolism" EXACT [GOC:TermGenie] synonym: "phytoene degradation" EXACT [GOC:TermGenie] is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901172 ! phytoene metabolic process created_by: yaf creation_date: 2012-07-19T09:48:07Z [Term] id: GO:1901174 name: phytoene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] synonym: "phytoene anabolism" EXACT [GOC:TermGenie] synonym: "phytoene biosynthesis" EXACT [GOC:TermGenie] synonym: "phytoene formation" EXACT [GOC:TermGenie] synonym: "phytoene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901172 ! phytoene metabolic process created_by: yaf creation_date: 2012-07-19T09:48:15Z [Term] id: GO:1901175 name: lycopene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] synonym: "lycopene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2012-07-19T09:48:20Z [Term] id: GO:1901176 name: lycopene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] synonym: "lycopene breakdown" EXACT [GOC:TermGenie] synonym: "lycopene catabolism" EXACT [GOC:TermGenie] synonym: "lycopene degradation" EXACT [GOC:TermGenie] is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901175 ! lycopene metabolic process created_by: yaf creation_date: 2012-07-19T09:48:41Z [Term] id: GO:1901177 name: lycopene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] synonym: "lycopene anabolism" EXACT [GOC:TermGenie] synonym: "lycopene biosynthesis" EXACT [GOC:TermGenie] synonym: "lycopene formation" EXACT [GOC:TermGenie] synonym: "lycopene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901175 ! lycopene metabolic process created_by: yaf creation_date: 2012-07-19T09:48:49Z [Term] id: GO:1901178 name: spheroidene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] synonym: "spheroidene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process is_a: GO:0018904 ! ether metabolic process created_by: yaf creation_date: 2012-07-19T09:48:54Z [Term] id: GO:1901179 name: spheroidene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] synonym: "spheroidene breakdown" EXACT [GOC:TermGenie] synonym: "spheroidene catabolism" EXACT [GOC:TermGenie] synonym: "spheroidene degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:1901178 ! spheroidene metabolic process is_a: GO:1901502 ! ether catabolic process created_by: yaf creation_date: 2012-07-19T09:49:14Z [Term] id: GO:1901180 name: spheroidene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] synonym: "spheroidene anabolism" EXACT [GOC:TermGenie] synonym: "spheroidene biosynthesis" EXACT [GOC:TermGenie] synonym: "spheroidene formation" EXACT [GOC:TermGenie] synonym: "spheroidene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:1901178 ! spheroidene metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: yaf creation_date: 2012-07-19T09:49:22Z [Term] id: GO:1901181 name: negative regulation of cellular response to caffeine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine." [GOC:TermGenie] synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie] is_a: GO:2001039 ! negative regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071313 ! cellular response to caffeine relationship: negatively_regulates GO:0071313 ! cellular response to caffeine created_by: al creation_date: 2012-07-19T04:11:46Z [Term] id: GO:1901182 name: regulation of camalexin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie] synonym: "regulation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of camalexin formation" EXACT [GOC:TermGenie] synonym: "regulation of camalexin synthesis" EXACT [GOC:TermGenie] is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010120 ! camalexin biosynthetic process relationship: regulates GO:0010120 ! camalexin biosynthetic process created_by: tb creation_date: 2012-07-23T02:16:52Z [Term] id: GO:1901183 name: positive regulation of camalexin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie] synonym: "activation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "activation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of camalexin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of camalexin formation" EXACT [GOC:TermGenie] synonym: "activation of camalexin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of camalexin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of camalexin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of camalexin formation" EXACT [GOC:TermGenie] synonym: "up regulation of camalexin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of camalexin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of camalexin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of camalexin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of camalexin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of camalexin formation" EXACT [GOC:TermGenie] synonym: "upregulation of camalexin synthesis" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process is_a: GO:1901182 ! regulation of camalexin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010120 ! camalexin biosynthetic process relationship: positively_regulates GO:0010120 ! camalexin biosynthetic process created_by: tb creation_date: 2012-07-23T02:17:21Z [Term] id: GO:1901184 name: regulation of ERBB signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038127 ! ERBB signaling pathway relationship: regulates GO:0038127 ! ERBB signaling pathway created_by: rl creation_date: 2012-07-24T07:37:11Z [Term] id: GO:1901185 name: negative regulation of ERBB signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "down regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "downregulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of ErbB signaling" EXACT [GOC:TermGenie] synonym: "inhibition of ERBB signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1901184 ! regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038127 ! ERBB signaling pathway relationship: negatively_regulates GO:0038127 ! ERBB signaling pathway created_by: rl creation_date: 2012-07-24T07:37:35Z [Term] id: GO:1901186 name: positive regulation of ERBB signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "activation of ERBB signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "up regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of ErbB signaling" EXACT [GOC:TermGenie] synonym: "upregulation of ERBB signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of ERBB signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1901184 ! regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038127 ! ERBB signaling pathway relationship: positively_regulates GO:0038127 ! ERBB signaling pathway created_by: rl creation_date: 2012-07-24T07:37:43Z [Term] id: GO:1901187 name: regulation of ephrin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048013 ! ephrin receptor signaling pathway relationship: regulates GO:0048013 ! ephrin receptor signaling pathway created_by: rl creation_date: 2012-07-24T07:41:49Z [Term] id: GO:1901188 name: negative regulation of ephrin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of ephrin receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway relationship: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway created_by: rl creation_date: 2012-07-24T07:42:14Z [Term] id: GO:1901189 name: positive regulation of ephrin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "activation of ephrin receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048013 ! ephrin receptor signaling pathway relationship: positively_regulates GO:0048013 ! ephrin receptor signaling pathway created_by: rl creation_date: 2012-07-24T07:42:21Z [Term] id: GO:1901190 name: regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001677 ! formation of translation initiation ternary complex relationship: regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:26:58Z [Term] id: GO:1901191 name: negative regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:21Z [Term] id: GO:1901192 name: positive regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001677 ! formation of translation initiation ternary complex relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:27:29Z [Term] id: GO:1901193 name: regulation of formation of translation preinitiation complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] synonym: "regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001731 ! formation of translation preinitiation complex relationship: regulates GO:0001731 ! formation of translation preinitiation complex created_by: ss creation_date: 2012-07-25T02:31:20Z [Term] id: GO:1901194 name: negative regulation of formation of translation preinitiation complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] synonym: "down regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "down regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation preinitiation complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "negative regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1901193 ! regulation of formation of translation preinitiation complex is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001731 ! formation of translation preinitiation complex relationship: negatively_regulates GO:0001731 ! formation of translation preinitiation complex created_by: ss creation_date: 2012-07-25T02:31:41Z [Term] id: GO:1901195 name: positive regulation of formation of translation preinitiation complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] synonym: "activation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "activation of formation of translation preinitiation complex" NARROW [GOC:TermGenie] synonym: "activation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "positive regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1901193 ! regulation of formation of translation preinitiation complex is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001731 ! formation of translation preinitiation complex relationship: positively_regulates GO:0001731 ! formation of translation preinitiation complex created_by: ss creation_date: 2012-07-25T02:31:50Z [Term] id: GO:1901196 name: positive regulation of calcium-mediated signaling involved in cellular response to salt stress namespace: biological_process def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress." [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to salt stress" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular salinity response" EXACT [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: part_of GO:0071472 ! cellular response to salt stress relationship: part_of GO:0071472 ! cellular response to salt stress created_by: al creation_date: 2012-07-27T10:52:56Z [Term] id: GO:1901197 name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion namespace: biological_process def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling intersection_of: part_of GO:0071277 ! cellular response to calcium ion relationship: part_of GO:0071277 ! cellular response to calcium ion created_by: al creation_date: 2012-07-27T10:57:56Z [Term] id: GO:1901198 name: positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion namespace: biological_process def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion." [GOC:TermGenie] synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol intersection_of: GO:0010524 ! positive regulation of calcium ion transport into cytosol intersection_of: part_of GO:0071277 ! cellular response to calcium ion relationship: part_of GO:0071277 ! cellular response to calcium ion created_by: al creation_date: 2012-07-27T11:07:43Z [Term] id: GO:1901199 name: positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress namespace: biological_process def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie] synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie] is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol intersection_of: GO:0010524 ! positive regulation of calcium ion transport into cytosol intersection_of: part_of GO:0071472 ! cellular response to salt stress relationship: part_of GO:0071472 ! cellular response to salt stress created_by: al creation_date: 2012-07-27T11:09:37Z [Term] id: GO:1901200 name: negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress namespace: biological_process def: "Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie] synonym: "negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] synonym: "negative regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie] is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol intersection_of: GO:0010523 ! negative regulation of calcium ion transport into cytosol intersection_of: part_of GO:0071472 ! cellular response to salt stress relationship: part_of GO:0071472 ! cellular response to salt stress created_by: al creation_date: 2012-07-27T11:11:09Z [Term] id: GO:1901201 name: regulation of extracellular matrix assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0085029 ! extracellular matrix assembly relationship: regulates GO:0085029 ! extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:00Z [Term] id: GO:1901202 name: negative regulation of extracellular matrix assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie] is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0085029 ! extracellular matrix assembly relationship: negatively_regulates GO:0085029 ! extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:24Z [Term] id: GO:1901203 name: positive regulation of extracellular matrix assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie] synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0085029 ! extracellular matrix assembly relationship: positively_regulates GO:0085029 ! extracellular matrix assembly created_by: rl creation_date: 2012-07-27T04:04:32Z [Term] id: GO:1901204 name: obsolete regulation of adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] is_obsolete: true created_by: hjd creation_date: 2012-07-30T18:32:51Z [Term] id: GO:1901205 name: obsolete negative regulation of adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "down regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "down-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "downregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "inhibition of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "negative regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] is_obsolete: true created_by: hjd creation_date: 2012-07-30T18:33:14Z [Term] id: GO:1901206 name: obsolete positive regulation of adrenergic receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "activation of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "activation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "positive regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "up regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "up-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "upregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] is_obsolete: true created_by: hjd creation_date: 2012-07-30T18:33:22Z [Term] id: GO:1901207 name: regulation of heart looping namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "regulation of cardiac looping" EXACT [GOC:TermGenie] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001947 ! heart looping relationship: regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:15:47Z [Term] id: GO:1901208 name: negative regulation of heart looping namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "down regulation of heart looping" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "down-regulation of heart looping" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "downregulation of heart looping" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac looping" EXACT [GOC:TermGenie] synonym: "inhibition of heart looping" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac looping" EXACT [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1901207 ! regulation of heart looping is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001947 ! heart looping relationship: negatively_regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:16:10Z [Term] id: GO:1901209 name: positive regulation of heart looping namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac looping" EXACT [GOC:TermGenie] synonym: "activation of heart looping" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up regulation of heart looping" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "up-regulation of heart looping" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac looping" EXACT [GOC:TermGenie] synonym: "upregulation of heart looping" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1901207 ! regulation of heart looping is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001947 ! heart looping relationship: positively_regulates GO:0001947 ! heart looping created_by: rl creation_date: 2012-07-31T07:16:18Z [Term] id: GO:1901210 name: regulation of cardiac chamber formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003207 ! cardiac chamber formation relationship: regulates GO:0003207 ! cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:18:35Z [Term] id: GO:1901211 name: negative regulation of cardiac chamber formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003207 ! cardiac chamber formation relationship: negatively_regulates GO:0003207 ! cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:18:57Z [Term] id: GO:1901212 name: positive regulation of cardiac chamber formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003207 ! cardiac chamber formation relationship: positively_regulates GO:0003207 ! cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:19:05Z [Term] id: GO:1901213 name: regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time." [GOC:BHF, GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development relationship: part_of GO:0007507 ! heart development created_by: rl creation_date: 2012-07-31T07:26:45Z [Term] id: GO:1901214 name: regulation of neuron death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] synonym: "regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "regulation of neuronal cell death" EXACT [GOC:TermGenie] is_a: GO:0010941 ! regulation of cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070997 ! neuron death relationship: regulates GO:0070997 ! neuron death created_by: rph creation_date: 2012-08-02T09:57:41Z [Term] id: GO:1901215 name: negative regulation of neuron death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] synonym: "down regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "down regulation of neuron death" EXACT [GOC:TermGenie] synonym: "down regulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron death" EXACT [GOC:TermGenie] synonym: "down-regulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "downregulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "downregulation of neuron death" EXACT [GOC:TermGenie] synonym: "downregulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "inhibition of neuron cell death" NARROW [GOC:TermGenie] synonym: "inhibition of neuron death" NARROW [GOC:TermGenie] synonym: "inhibition of neuronal cell death" NARROW [GOC:TermGenie] synonym: "negative regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "negative regulation of neuronal cell death" EXACT [GOC:TermGenie] is_a: GO:0060548 ! negative regulation of cell death is_a: GO:1901214 ! regulation of neuron death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070997 ! neuron death relationship: negatively_regulates GO:0070997 ! neuron death created_by: rph creation_date: 2012-08-02T09:58:07Z [Term] id: GO:1901216 name: positive regulation of neuron death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] synonym: "activation of neuron cell death" NARROW [GOC:TermGenie] synonym: "activation of neuron death" NARROW [GOC:TermGenie] synonym: "activation of neuronal cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "up regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "up regulation of neuron death" EXACT [GOC:TermGenie] synonym: "up regulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "up-regulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "up-regulation of neuron death" EXACT [GOC:TermGenie] synonym: "up-regulation of neuronal cell death" EXACT [GOC:TermGenie] synonym: "upregulation of neuron cell death" EXACT [GOC:TermGenie] synonym: "upregulation of neuron death" EXACT [GOC:TermGenie] synonym: "upregulation of neuronal cell death" EXACT [GOC:TermGenie] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:1901214 ! regulation of neuron death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070997 ! neuron death relationship: positively_regulates GO:0070997 ! neuron death created_by: rph creation_date: 2012-08-02T09:58:15Z [Term] id: GO:1901217 name: regulation of holin activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0051709 ! regulation of killing of cells of other organism is_a: GO:1902186 ! regulation of viral release from host cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034290 ! holin activity relationship: regulates GO:0034290 ! holin activity created_by: bf creation_date: 2012-08-06T10:47:38Z [Term] id: GO:1901218 name: negative regulation of holin activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie] synonym: "antiholin activity" EXACT [] synonym: "down regulation of holin activity" EXACT [GOC:TermGenie] synonym: "down-regulation of holin activity" EXACT [GOC:TermGenie] synonym: "downregulation of holin activity" EXACT [GOC:TermGenie] synonym: "inhibition of holin activity" NARROW [GOC:TermGenie] synonym: "phage antiholin" NARROW [GOC:bm] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0051711 ! negative regulation of killing of cells of other organism is_a: GO:1901217 ! regulation of holin activity is_a: GO:1902187 ! negative regulation of viral release from host cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034290 ! holin activity relationship: negatively_regulates GO:0034290 ! holin activity created_by: bf creation_date: 2012-08-06T10:48:00Z [Term] id: GO:1901219 name: regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003206 ! cardiac chamber morphogenesis relationship: regulates GO:0003206 ! cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:11Z [Term] id: GO:1901220 name: negative regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis relationship: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:34Z [Term] id: GO:1901221 name: positive regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003206 ! cardiac chamber morphogenesis relationship: positively_regulates GO:0003206 ! cardiac chamber morphogenesis created_by: rl creation_date: 2012-08-06T17:59:42Z [Term] id: GO:1901222 name: regulation of NIK/NF-kappaB signaling namespace: biological_process alt_id: GO:0042345 alt_id: GO:0042348 def: "Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] synonym: "NF-kappaB import into nucleus" NARROW [] synonym: "NF-KB import into nucleus" NARROW [GOC:bf] synonym: "regulation of NF-kappaB import into nucleus" NARROW [] synonym: "regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038061 ! NIK/NF-kappaB signaling relationship: regulates GO:0038061 ! NIK/NF-kappaB signaling created_by: hjd creation_date: 2012-08-06T20:27:17Z [Term] id: GO:1901223 name: negative regulation of NIK/NF-kappaB signaling namespace: biological_process alt_id: GO:0042347 def: "Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] synonym: "down regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "down regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "down regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "down regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "down-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "down-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "down-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "downregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "downregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "downregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "downregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "inhibition of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie] synonym: "inhibition of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "inhibition of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "inhibition of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "negative regulation of NF-kappaB import into nucleus" NARROW [] synonym: "negative regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "negative regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "negative regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "negative regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038061 ! NIK/NF-kappaB signaling relationship: negatively_regulates GO:0038061 ! NIK/NF-kappaB signaling created_by: hjd creation_date: 2012-08-06T20:27:39Z [Term] id: GO:1901224 name: positive regulation of NIK/NF-kappaB signaling namespace: biological_process alt_id: GO:0008588 alt_id: GO:0042346 def: "Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] synonym: "activation of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie] synonym: "activation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "activation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "activation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "negative regulation of cytoplasmic NF-kappaB storage" NARROW [] synonym: "positive regulation of NF-kappaB import into nucleus" NARROW [] synonym: "positive regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "positive regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "positive regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "positive regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "release of cytoplasmic sequestered NF-kappaB" NARROW [] synonym: "release of NF-kappaB sequestered in cytoplasm" NARROW [] synonym: "up regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "up regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "up regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "up regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "up-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "up-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "up-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] synonym: "upregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] synonym: "upregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] synonym: "upregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] synonym: "upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] synonym: "upregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038061 ! NIK/NF-kappaB signaling relationship: positively_regulates GO:0038061 ! NIK/NF-kappaB signaling created_by: hjd creation_date: 2012-08-06T20:27:47Z [Term] id: GO:1901225 name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [] is_obsolete: true created_by: rl creation_date: 2012-08-07T07:04:07Z [Term] id: GO:1901226 name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "activation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "activation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "activation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [] synonym: "up regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "upregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2012-08-07T07:04:32Z [Term] id: GO:1901227 name: negative regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development created_by: pr creation_date: 2012-08-07T12:50:30Z [Term] id: GO:1901228 name: positive regulation of transcription from RNA polymerase II promoter involved in heart development namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007507 ! heart development created_by: pr creation_date: 2012-08-07T12:53:01Z [Term] id: GO:1901229 name: regulation of non-canonical Wnt signaling pathway via JNK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] synonym: "regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] synonym: "regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade relationship: regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade created_by: vk creation_date: 2012-08-07T14:14:16Z [Term] id: GO:1901230 name: negative regulation of non-canonical Wnt signaling pathway via JNK cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie] synonym: "inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] synonym: "negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" RELATED [GOC:signaling] is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade relationship: negatively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade created_by: vk creation_date: 2012-08-07T14:14:39Z [Term] id: GO:1901231 name: positive regulation of non-canonical Wnt signaling pathway via JNK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] synonym: "activation of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie] synonym: "activation of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] synonym: "positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] synonym: "up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] synonym: "upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade relationship: positively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade created_by: vk creation_date: 2012-08-07T14:14:48Z [Term] id: GO:1901232 name: regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060028 ! convergent extension involved in axis elongation relationship: regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:21:46Z [Term] id: GO:1901233 name: negative regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation relationship: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:22:11Z [Term] id: GO:1901234 name: positive regulation of convergent extension involved in axis elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] synonym: "activation of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060028 ! convergent extension involved in axis elongation relationship: positively_regulates GO:0060028 ! convergent extension involved in axis elongation created_by: vk creation_date: 2012-08-07T14:22:19Z [Term] id: GO:1901235 name: (R)-carnitine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of (R)-carnitine from one side of a membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798] xref: RHEA:34959 is_a: GO:0015226 ! carnitine transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:1902270 ! (R)-carnitine transmembrane transport created_by: jl creation_date: 2012-08-07T14:46:17Z [Term] id: GO:1901236 name: 4-(trimethylammonio)butanoate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other." [GOC:TermGenie, PMID:16952940, PMID:21784948] xref: RHEA:32835 is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity created_by: jl creation_date: 2012-08-07T14:46:52Z [Term] id: GO:1901238 name: ATPase-coupled tungstate transmembrane transporter activity namespace: molecular_function alt_id: GO:1901237 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)." [GOC:TermGenie, PMID:16952940, PMID:21784948] synonym: "tungstate transmembrane transporter activity" BROAD [] synonym: "tungstate transmembrane-transporting ATPase activity" RELATED [] xref: EC:7.3.2.6 xref: RHEA:35027 is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity created_by: jl creation_date: 2012-08-07T14:47:36Z [Term] id: GO:1901239 name: malonate(1-) transmembrane transporter activity namespace: molecular_function alt_id: GO:1901549 def: "Enables the transfer of malonate(1-) from one side of a membrane to the other." [GOC:TermGenie, PMID:9128730, PMID:9573154] synonym: "malonic acid uptake transmembrane transporter activity" RELATED [] xref: RHEA:33115 is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:1901553 ! malonic acid transmembrane transport created_by: al creation_date: 2012-08-07T15:09:02Z [Term] id: GO:1901241 name: 4-hydroxyphenylacetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other." [GOC:TermGenie, PMID:9315705] xref: RHEA:33175 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity created_by: jl creation_date: 2012-08-07T15:09:49Z [Term] id: GO:1901242 name: ATPase-coupled doxorubicin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)." [GOC:TermGenie, PMID:12057006] synonym: "doxorubicin transmembrane-transporting ATPase activity" RELATED [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity created_by: jl creation_date: 2012-08-07T15:10:13Z [Term] id: GO:1901243 name: ATPase-coupled methionine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + methionine(in) = ADP + phosphate + methionine(out)." [GOC:TermGenie, PMID:12169620, PMID:12819857] synonym: "ATP-dependent methionine transmembrane transporter activity" EXACT [] synonym: "methionine transmembrane-transporting ATPase activity" RELATED [] xref: RHEA:32827 is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity is_a: GO:0043865 ! methionine transmembrane transporter activity created_by: jl creation_date: 2012-08-07T15:59:50Z [Term] id: GO:1901244 name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus." [GOC:kmv, GOC:TermGenie] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] is_obsolete: true created_by: kmv creation_date: 2012-08-07T18:40:02Z [Term] id: GO:1901245 name: positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization namespace: biological_process def: "The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling." [GOC:amm, GOC:bf, GOC:TermGenie, PMID:18513998] synonym: "BCR-induced TLR9 recruitment" NARROW [PMID:18513998] synonym: "positive regulation of TLR9 signaling pathway by B cell receptor internalization" EXACT [GOC:TermGenie] synonym: "positive regulation of TLR9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of TLR9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] synonym: "positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization" EXACT [GOC:TermGenie] synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] is_a: GO:0034165 ! positive regulation of toll-like receptor 9 signaling pathway is_a: GO:0036300 ! B cell receptor internalization is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization intersection_of: GO:0036300 ! B cell receptor internalization intersection_of: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway created_by: bf creation_date: 2012-08-08T08:12:44Z [Term] id: GO:1901246 name: regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061141 ! lung ciliated cell differentiation relationship: regulates GO:0061141 ! lung ciliated cell differentiation created_by: vk creation_date: 2012-08-08T08:58:34Z [Term] id: GO:1901247 name: negative regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901246 ! regulation of lung ciliated cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061141 ! lung ciliated cell differentiation relationship: negatively_regulates GO:0061141 ! lung ciliated cell differentiation created_by: vk creation_date: 2012-08-08T08:58:58Z [Term] id: GO:1901248 name: positive regulation of lung ciliated cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901246 ! regulation of lung ciliated cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061141 ! lung ciliated cell differentiation relationship: positively_regulates GO:0061141 ! lung ciliated cell differentiation created_by: vk creation_date: 2012-08-08T08:59:05Z [Term] id: GO:1901249 name: regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060480 ! lung goblet cell differentiation relationship: regulates GO:0060480 ! lung goblet cell differentiation created_by: vk creation_date: 2012-08-08T08:59:12Z [Term] id: GO:1901250 name: negative regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lung goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901249 ! regulation of lung goblet cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060480 ! lung goblet cell differentiation relationship: negatively_regulates GO:0060480 ! lung goblet cell differentiation created_by: vk creation_date: 2012-08-08T08:59:36Z [Term] id: GO:1901251 name: positive regulation of lung goblet cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] synonym: "activation of lung goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901249 ! regulation of lung goblet cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060480 ! lung goblet cell differentiation relationship: positively_regulates GO:0060480 ! lung goblet cell differentiation created_by: vk creation_date: 2012-08-08T08:59:44Z [Term] id: GO:1901252 name: regulation of intracellular transport of viral material namespace: biological_process def: "Any process that modulates the frequency, rate or extent of egress of virus within host cell." [GOC:bf, GOC:jl, GOC:TermGenie] synonym: "regulation of egress of virus within host cell" RELATED [] synonym: "regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "regulation of viral egress" EXACT [GOC:TermGenie] is_a: GO:0051049 ! regulation of transport is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0075733 ! intracellular transport of virus relationship: regulates GO:0075733 ! intracellular transport of virus created_by: ss creation_date: 2012-08-09T05:45:25Z [Term] id: GO:1901253 name: negative regulation of intracellular transport of viral material namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie] synonym: "down regulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "down regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "down regulation of viral egress" EXACT [GOC:TermGenie] synonym: "down-regulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "down-regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "down-regulation of viral egress" EXACT [GOC:TermGenie] synonym: "downregulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "downregulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "downregulation of viral egress" EXACT [GOC:TermGenie] synonym: "inhibition of egress of virus within host cell" NARROW [GOC:TermGenie] synonym: "inhibition of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "inhibition of viral egress" EXACT [GOC:TermGenie] synonym: "negative regulation of egress of virus within host cell" RELATED [] synonym: "negative regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "negative regulation of viral egress" EXACT [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1901252 ! regulation of intracellular transport of viral material is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0075733 ! intracellular transport of virus relationship: negatively_regulates GO:0075733 ! intracellular transport of virus created_by: ss creation_date: 2012-08-09T05:45:47Z [Term] id: GO:1901254 name: positive regulation of intracellular transport of viral material namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie] synonym: "activation of egress of virus within host cell" NARROW [GOC:TermGenie] synonym: "activation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "activation of viral egress" EXACT [GOC:TermGenie] synonym: "positive regulation of egress of virus within host cell" RELATED [] synonym: "positive regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "positive regulation of viral egress" EXACT [GOC:TermGenie] synonym: "up regulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "up regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "up regulation of viral egress" EXACT [GOC:TermGenie] synonym: "up-regulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "up-regulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "up-regulation of viral egress" EXACT [GOC:TermGenie] synonym: "upregulation of egress of virus within host cell" EXACT [GOC:TermGenie] synonym: "upregulation of movement of virus within host cell" EXACT [GOC:TermGenie] synonym: "upregulation of viral egress" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1901252 ! regulation of intracellular transport of viral material is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0075733 ! intracellular transport of virus relationship: positively_regulates GO:0075733 ! intracellular transport of virus created_by: ss creation_date: 2012-08-09T05:45:54Z [Term] id: GO:1901255 name: nucleotide-excision repair involved in interstrand cross-link repair namespace: biological_process def: "Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477] synonym: "NER involved in ICL repair" EXACT [GOC:TermGenie] synonym: "NER involved in interstrand cross-link repair" EXACT [GOC:TermGenie] synonym: "nucleotide-excision repair involved in ICL repair" EXACT [GOC:TermGenie] is_a: GO:0006289 ! nucleotide-excision repair intersection_of: GO:0006289 ! nucleotide-excision repair intersection_of: part_of GO:0036297 ! interstrand cross-link repair relationship: part_of GO:0036297 ! interstrand cross-link repair created_by: vw creation_date: 2012-08-09T06:09:50Z [Term] id: GO:1901256 name: regulation of macrophage colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] synonym: "regulation of M-CSF production" EXACT [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036301 ! macrophage colony-stimulating factor production relationship: regulates GO:0036301 ! macrophage colony-stimulating factor production created_by: vk creation_date: 2012-08-10T08:28:08Z [Term] id: GO:1901257 name: negative regulation of macrophage colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "down regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] synonym: "down-regulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] synonym: "downregulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] synonym: "inhibition of M-CSF production" EXACT [GOC:TermGenie] synonym: "inhibition of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie] synonym: "negative regulation of M-CSF production" EXACT [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production relationship: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production created_by: vk creation_date: 2012-08-10T08:28:28Z [Term] id: GO:1901258 name: positive regulation of macrophage colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] synonym: "activation of M-CSF production" EXACT [GOC:TermGenie] synonym: "activation of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie] synonym: "positive regulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "up regulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "up regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] synonym: "up-regulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] synonym: "upregulation of M-CSF production" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production relationship: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production created_by: vk creation_date: 2012-08-10T08:28:36Z [Term] id: GO:1901259 name: chloroplast rRNA processing namespace: biological_process def: "Any rRNA processing that takes place in chloroplast." [GOC:TermGenie] is_a: GO:0006364 ! rRNA processing intersection_of: GO:0006364 ! rRNA processing intersection_of: occurs_in GO:0009507 ! chloroplast relationship: occurs_in GO:0009507 ! chloroplast created_by: tb creation_date: 2012-08-10T17:43:19Z [Term] id: GO:1901260 name: peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification namespace: biological_process def: "Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification." [GOC:imk, GOC:TermGenie, PMID:22706199] synonym: "EF-P lysine hydroxylation" RELATED [PMID:3555234] is_a: GO:0017185 ! peptidyl-lysine hydroxylation intersection_of: GO:0017185 ! peptidyl-lysine hydroxylation intersection_of: part_of GO:0072580 ! bacterial-type EF-P lysine modification relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification created_by: bf creation_date: 2012-08-14T13:20:12Z [Term] id: GO:1901261 name: regulation of sorocarp spore cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] is_a: GO:0031156 ! regulation of sorocarp development is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044671 ! sorocarp spore cell differentiation relationship: regulates GO:0044671 ! sorocarp spore cell differentiation created_by: jl creation_date: 2012-08-15T09:44:30Z [Term] id: GO:1901262 name: negative regulation of sorocarp spore cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] synonym: "down regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of sorocarp spore cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation relationship: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation created_by: jl creation_date: 2012-08-15T09:44:50Z [Term] id: GO:1901263 name: positive regulation of sorocarp spore cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] synonym: "activation of sorocarp spore cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044671 ! sorocarp spore cell differentiation relationship: positively_regulates GO:0044671 ! sorocarp spore cell differentiation created_by: jl creation_date: 2012-08-15T09:44:58Z [Term] id: GO:1901264 name: carbohydrate derivative transport namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0071702 ! organic substance transport created_by: bf creation_date: 2012-08-16T14:51:22Z [Term] id: GO:1901265 name: nucleoside phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with nucleoside phosphate." [GOC:TermGenie] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: bf creation_date: 2012-08-17T12:59:58Z [Term] id: GO:1901266 name: cephalosporin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] synonym: "cephalosporin C metabolism" EXACT [GOC:TermGenie] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0043645 ! cephalosporin metabolic process created_by: yaf creation_date: 2012-08-17T14:25:59Z [Term] id: GO:1901267 name: cephalosporin C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie] synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie] synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901266 ! cephalosporin C metabolic process created_by: yaf creation_date: 2012-08-17T14:26:19Z [Term] id: GO:1901268 name: cephalosporin C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] synonym: "cephalosporin C anabolism" EXACT [GOC:TermGenie] synonym: "cephalosporin C biosynthesis" EXACT [GOC:TermGenie] synonym: "cephalosporin C formation" EXACT [GOC:TermGenie] synonym: "cephalosporin C synthesis" EXACT [GOC:TermGenie] is_a: GO:0043646 ! cephalosporin biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901266 ! cephalosporin C metabolic process created_by: yaf creation_date: 2012-08-17T14:26:31Z [Term] id: GO:1901269 name: lipooligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] synonym: "lipooligosaccharide metabolism" EXACT [GOC:TermGenie] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: yaf creation_date: 2012-08-17T14:31:26Z [Term] id: GO:1901270 name: lipooligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] synonym: "lipooligosaccharide breakdown" EXACT [GOC:TermGenie] synonym: "lipooligosaccharide catabolism" EXACT [GOC:TermGenie] synonym: "lipooligosaccharide degradation" EXACT [GOC:TermGenie] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1901269 ! lipooligosaccharide metabolic process created_by: yaf creation_date: 2012-08-17T14:31:48Z [Term] id: GO:1901271 name: lipooligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] synonym: "lipooligosaccharide anabolism" EXACT [GOC:TermGenie] synonym: "lipooligosaccharide biosynthesis" EXACT [GOC:TermGenie] synonym: "lipooligosaccharide formation" EXACT [GOC:TermGenie] synonym: "lipooligosaccharide synthesis" EXACT [GOC:TermGenie] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901269 ! lipooligosaccharide metabolic process created_by: yaf creation_date: 2012-08-17T14:31:55Z [Term] id: GO:1901272 name: 2-dehydro-3-deoxy-D-gluconic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] synonym: "2-dehydro-3-deoxy-D-gluconic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0019520 ! aldonic acid metabolic process created_by: yaf creation_date: 2012-08-17T14:46:15Z [Term] id: GO:1901273 name: 2-dehydro-3-deoxy-D-gluconic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] synonym: "2-dehydro-3-deoxy-D-gluconic acid breakdown" EXACT [GOC:TermGenie] synonym: "2-dehydro-3-deoxy-D-gluconic acid catabolism" EXACT [GOC:TermGenie] synonym: "2-dehydro-3-deoxy-D-gluconic acid degradation" EXACT [GOC:TermGenie] is_a: GO:0046176 ! aldonic acid catabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process created_by: yaf creation_date: 2012-08-17T14:46:37Z [Term] id: GO:1901274 name: 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] synonym: "2-dehydro-3-deoxy-D-gluconic acid anabolism" EXACT [GOC:TermGenie] synonym: "2-dehydro-3-deoxy-D-gluconic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "2-dehydro-3-deoxy-D-gluconic acid formation" EXACT [GOC:TermGenie] synonym: "2-dehydro-3-deoxy-D-gluconic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0046175 ! aldonic acid biosynthetic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process created_by: yaf creation_date: 2012-08-17T14:46:44Z [Term] id: GO:1901275 name: tartrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] synonym: "tartrate metabolism" EXACT [GOC:TermGenie] is_a: GO:0008152 ! metabolic process created_by: yaf creation_date: 2012-08-17T14:52:19Z [Term] id: GO:1901276 name: tartrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] synonym: "tartrate breakdown" EXACT [GOC:TermGenie] synonym: "tartrate catabolism" EXACT [GOC:TermGenie] synonym: "tartrate degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901275 ! tartrate metabolic process created_by: yaf creation_date: 2012-08-17T14:52:40Z [Term] id: GO:1901277 name: tartrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] synonym: "tartrate anabolism" EXACT [GOC:TermGenie] synonym: "tartrate biosynthesis" EXACT [GOC:TermGenie] synonym: "tartrate formation" EXACT [GOC:TermGenie] synonym: "tartrate synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901275 ! tartrate metabolic process created_by: yaf creation_date: 2012-08-17T14:52:48Z [Term] id: GO:1901278 name: D-ribose 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] synonym: "D-ribose 5-phosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0019693 ! ribose phosphate metabolic process created_by: yaf creation_date: 2012-08-17T14:59:58Z [Term] id: GO:1901279 name: D-ribose 5-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] synonym: "D-ribose 5-phosphate breakdown" EXACT [GOC:TermGenie] synonym: "D-ribose 5-phosphate catabolism" EXACT [GOC:TermGenie] synonym: "D-ribose 5-phosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process created_by: yaf creation_date: 2012-08-17T15:00:19Z [Term] id: GO:1901280 name: D-ribose 5-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] synonym: "D-ribose 5-phosphate anabolism" EXACT [GOC:TermGenie] synonym: "D-ribose 5-phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "D-ribose 5-phosphate formation" EXACT [GOC:TermGenie] synonym: "D-ribose 5-phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0046390 ! ribose phosphate biosynthetic process is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process created_by: yaf creation_date: 2012-08-17T15:00:27Z [Term] id: GO:1901281 name: fructoselysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784] synonym: "fructosyllysine breakdown" EXACT [GOC:TermGenie] synonym: "fructosyllysine catabolic process" EXACT [] synonym: "fructosyllysine catabolism" EXACT [GOC:TermGenie] synonym: "fructosyllysine degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0030392 ! fructosamine catabolic process is_a: GO:0030393 ! fructoselysine metabolic process created_by: yaf creation_date: 2012-08-17T15:04:43Z [Term] id: GO:1901282 name: fructoselysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784] synonym: "fructosyllysine anabolism" EXACT [GOC:TermGenie] synonym: "fructosyllysine biosynthesis" EXACT [GOC:TermGenie] synonym: "fructosyllysine biosynthetic process" EXACT [] synonym: "fructosyllysine formation" EXACT [GOC:TermGenie] synonym: "fructosyllysine synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0030391 ! fructosamine biosynthetic process is_a: GO:0030393 ! fructoselysine metabolic process created_by: yaf creation_date: 2012-08-17T15:05:05Z [Term] id: GO:1901283 name: 5,6,7,8-tetrahydromethanopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] synonym: "5,6,7,8-tetrahydromethanopterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:2001117 ! tetrahydromethanopterin metabolic process created_by: yaf creation_date: 2012-08-17T15:32:33Z [Term] id: GO:1901284 name: 5,6,7,8-tetrahydromethanopterin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] synonym: "5,6,7,8-tetrahydromethanopterin breakdown" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydromethanopterin catabolism" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydromethanopterin degradation" EXACT [GOC:TermGenie] is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process created_by: yaf creation_date: 2012-08-17T15:32:54Z [Term] id: GO:1901285 name: 5,6,7,8-tetrahydromethanopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] synonym: "5,6,7,8-tetrahydromethanopterin anabolism" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydromethanopterin biosynthesis" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydromethanopterin formation" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydromethanopterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process created_by: yaf creation_date: 2012-08-17T15:33:02Z [Term] id: GO:1901286 name: iron-sulfur-molybdenum cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] synonym: "FeMo-co metabolic process" EXACT [GOC:yaf] synonym: "FeMo-co metabolism" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf] synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie] is_a: GO:0051186 ! cofactor metabolic process created_by: yaf creation_date: 2012-08-17T15:39:14Z [Term] id: GO:1901287 name: iron-sulfur-molybdenum cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] synonym: "FeMo-co breakdown" EXACT [GOC:yaf] synonym: "FeMo-co catabolic process" EXACT [GOC:yaf] synonym: "FeMo-co catabolism" EXACT [GOC:yaf] synonym: "FeMo-co degradation" EXACT [GOC:yaf] synonym: "iron-molybdenum breakdown" EXACT [GOC:yaf] synonym: "iron-molybdenum catabolic process" EXACT [GOC:yaf] synonym: "iron-molybdenum catabolism" EXACT [GOC:yaf] synonym: "iron-molybdenum degradation" EXACT [GOC:yaf] synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie] is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process created_by: yaf creation_date: 2012-08-17T15:39:36Z [Term] id: GO:1901288 name: iron-sulfur-molybdenum cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] synonym: "FeMo-co anabolism" EXACT [GOC:yaf] synonym: "FeMo-co biosynthesis" EXACT [GOC:yaf] synonym: "FeMo-co biosynthetic process" EXACT [GOC:yaf] synonym: "FeMo-co formation" EXACT [GOC:yaf] synonym: "FeMo-co synthesis" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor anabolism" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor biosynthesis" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor biosynthetic process" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor formation" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor synthesis" EXACT [GOC:yaf] synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie] is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process created_by: yaf creation_date: 2012-08-17T15:39:48Z [Term] id: GO:1901289 name: succinyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929] synonym: "succinyl-CoA breakdown" EXACT [GOC:TermGenie] synonym: "succinyl-CoA catabolism" EXACT [GOC:TermGenie] synonym: "succinyl-CoA degradation" EXACT [GOC:TermGenie] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0044273 ! sulfur compound catabolic process created_by: yaf creation_date: 2012-08-17T16:13:37Z [Term] id: GO:1901290 name: succinyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929] synonym: "succinyl-CoA anabolism" EXACT [GOC:TermGenie] synonym: "succinyl-CoA biosynthesis" EXACT [GOC:TermGenie] synonym: "succinyl-CoA formation" EXACT [GOC:TermGenie] synonym: "succinyl-CoA synthesis" EXACT [GOC:TermGenie] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process created_by: yaf creation_date: 2012-08-17T16:13:57Z [Term] id: GO:1901291 name: negative regulation of double-strand break repair via single-strand annealing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing." [GOC:sart, GOC:TermGenie] synonym: "down regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] synonym: "down-regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] synonym: "downregulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] synonym: "inhibition of double-strand break repair via single-strand annealing" NARROW [GOC:TermGenie] is_a: GO:2000780 ! negative regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing relationship: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing created_by: sart creation_date: 2012-08-20T09:03:03Z [Term] id: GO:1901292 name: nucleoside phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate breakdown" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate catabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process created_by: bf creation_date: 2012-08-20T12:33:25Z [Term] id: GO:1901293 name: nucleoside phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process created_by: bf creation_date: 2012-08-20T12:33:45Z [Term] id: GO:1901294 name: obsolete negative regulation of SREBP signaling pathway by negative regulation of DNA binding namespace: biological_process def: "OBSOLETE. Negative regulation of DNA binding that results in negative regulation of a SREBP signaling pathway." [GOC:TermGenie, PMID:22017871] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. synonym: "inhibition of SREBP-dependent transcription by blocking DNA binding" EXACT [PMID:22017871] synonym: "negative regulation of SREBP signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-08-20T14:11:03Z [Term] id: GO:1901295 name: regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] synonym: "regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] synonym: "regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment relationship: regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment created_by: vk creation_date: 2012-08-21T09:06:32Z [Term] id: GO:1901296 name: negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment is_a: GO:1905067 ! negative regulation of canonical Wnt signaling pathway involved in heart development is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment relationship: negatively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment created_by: vk creation_date: 2012-08-21T09:06:52Z [Term] id: GO:1901297 name: positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] synonym: "activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] synonym: "up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment is_a: GO:1905068 ! positive regulation of canonical Wnt signaling pathway involved in heart development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment relationship: positively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment created_by: vk creation_date: 2012-08-21T09:06:59Z [Term] id: GO:1901298 name: regulation of hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death relationship: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death created_by: vk creation_date: 2012-08-21T09:44:59Z [Term] id: GO:1901299 name: negative regulation of hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] synonym: "inhibition of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death relationship: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death created_by: vk creation_date: 2012-08-21T09:45:21Z [Term] id: GO:1901300 name: positive regulation of hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] synonym: "activation of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death is_a: GO:1905206 ! positive regulation of hydrogen peroxide-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death relationship: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death created_by: vk creation_date: 2012-08-21T09:45:29Z [Term] id: GO:1901301 name: regulation of cargo loading into COPII-coated vesicle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885] synonym: "regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090110 ! COPII-coated vesicle cargo loading relationship: regulates GO:0090110 ! COPII-coated vesicle cargo loading created_by: bf creation_date: 2012-08-21T13:03:00Z [Term] id: GO:1901303 name: negative regulation of cargo loading into COPII-coated vesicle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885] synonym: "down regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] synonym: "downregulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "inhibition of cargo loading into COPII-coated vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "inhibition of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of COPII vesicle protein binding" NARROW [PMID:15899885] synonym: "inhibition of protein sorting into COPII-coated vesicles" EXACT [PMID:15899885] synonym: "negative regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1901301 ! regulation of cargo loading into COPII-coated vesicle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090110 ! COPII-coated vesicle cargo loading relationship: negatively_regulates GO:0090110 ! COPII-coated vesicle cargo loading created_by: bf creation_date: 2012-08-21T13:05:46Z [Term] id: GO:1901304 name: regulation of spermidine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] synonym: "regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "regulation of spermidine synthesis" EXACT [GOC:TermGenie] is_a: GO:0010967 ! regulation of polyamine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008295 ! spermidine biosynthetic process relationship: regulates GO:0008295 ! spermidine biosynthetic process created_by: pm creation_date: 2012-08-21T13:58:23Z [Term] id: GO:1901305 name: negative regulation of spermidine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] synonym: "down regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "down regulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "downregulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of spermidine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of spermidine formation" EXACT [GOC:TermGenie] synonym: "inhibition of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of spermidine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:1901304 ! regulation of spermidine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008295 ! spermidine biosynthetic process relationship: negatively_regulates GO:0008295 ! spermidine biosynthetic process created_by: pm creation_date: 2012-08-21T13:58:45Z [Term] id: GO:1901307 name: positive regulation of spermidine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] synonym: "activation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "activation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of spermidine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of spermidine formation" EXACT [GOC:TermGenie] synonym: "activation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "up regulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of spermidine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of spermidine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of spermidine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of spermidine formation" EXACT [GOC:TermGenie] synonym: "upregulation of spermidine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:1901304 ! regulation of spermidine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008295 ! spermidine biosynthetic process relationship: positively_regulates GO:0008295 ! spermidine biosynthetic process created_by: pm creation_date: 2012-08-21T14:02:58Z [Term] id: GO:1901308 name: regulation of sterol regulatory element binding protein cleavage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie] synonym: "regulation of SREBP cleavage" EXACT [GOC:TermGenie] is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0070613 ! regulation of protein processing is_a: GO:2000638 ! regulation of SREBP signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035103 ! sterol regulatory element binding protein cleavage relationship: regulates GO:0035103 ! sterol regulatory element binding protein cleavage created_by: bf creation_date: 2012-08-21T16:43:12Z [Term] id: GO:1901309 name: negative regulation of sterol regulatory element binding protein cleavage namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117] synonym: "down regulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "down regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] synonym: "down-regulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "down-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] synonym: "downregulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "downregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] synonym: "inhibition of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "inhibition of SREBP processing" EXACT [GOC:bf] synonym: "inhibition of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie] synonym: "negative regulation of SREBP cleavage" EXACT [GOC:TermGenie] is_a: GO:0010955 ! negative regulation of protein processing is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage is_a: GO:2000639 ! negative regulation of SREBP signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage relationship: negatively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage created_by: bf creation_date: 2012-08-21T16:43:32Z [Term] id: GO:1901310 name: positive regulation of sterol regulatory element binding protein cleavage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117] synonym: "activation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "activation of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie] synonym: "positive regulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "up regulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "up regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] synonym: "up-regulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "up-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] synonym: "upregulation of SREBP cleavage" EXACT [GOC:TermGenie] synonym: "upregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] is_a: GO:0010954 ! positive regulation of protein processing is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage is_a: GO:2000640 ! positive regulation of SREBP signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage relationship: positively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage created_by: bf creation_date: 2012-08-21T16:43:40Z [Term] id: GO:1901311 name: obsolete regulation of gene expression involved in extracellular matrix organization namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. synonym: "regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] is_obsolete: true consider: GO:0010468 created_by: vk creation_date: 2012-08-22T09:18:13Z [Term] id: GO:1901312 name: obsolete negative regulation of gene expression involved in extracellular matrix organization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. synonym: "down regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "down regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "down-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "downregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "inhibition of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "inhibition of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "negative regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] is_obsolete: true consider: GO:0010629 created_by: vk creation_date: 2012-08-22T09:18:35Z [Term] id: GO:1901313 name: obsolete positive regulation of gene expression involved in extracellular matrix organization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. synonym: "activation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "activation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "activation of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "positive regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "up regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "up regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "up-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix protein production" RELATED [GOC:TermGenie] synonym: "upregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] is_obsolete: true consider: GO:0010628 created_by: vk creation_date: 2012-08-22T09:18:42Z [Term] id: GO:1901314 name: regulation of histone H2A K63-linked ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] is_a: GO:0033182 ! regulation of histone ubiquitination is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070535 ! histone H2A K63-linked ubiquitination relationship: regulates GO:0070535 ! histone H2A K63-linked ubiquitination created_by: tb creation_date: 2012-08-22T20:29:04Z [Term] id: GO:1901315 name: negative regulation of histone H2A K63-linked ubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] synonym: "down regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "inhibition of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie] is_a: GO:0033183 ! negative regulation of histone ubiquitination is_a: GO:1900045 ! negative regulation of protein K63-linked ubiquitination is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination relationship: negatively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination created_by: tb creation_date: 2012-08-22T20:29:24Z [Term] id: GO:1901316 name: positive regulation of histone H2A K63-linked ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] synonym: "activation of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie] synonym: "up regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] is_a: GO:0033184 ! positive regulation of histone ubiquitination is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination is_a: GO:1902523 ! positive regulation of protein K63-linked ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination relationship: positively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination created_by: tb creation_date: 2012-08-22T20:29:32Z [Term] id: GO:1901317 name: regulation of flagellated sperm motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "regulation of sperm motility" BROAD [] synonym: "regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030317 ! flagellated sperm motility relationship: regulates GO:0030317 ! flagellated sperm motility created_by: hjd creation_date: 2012-08-22T20:50:14Z [Term] id: GO:1901318 name: negative regulation of flagellated sperm motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie] synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie] synonym: "negative regulation of sperm motility" BROAD [] synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030317 ! flagellated sperm motility relationship: negatively_regulates GO:0030317 ! flagellated sperm motility created_by: hjd creation_date: 2012-08-22T20:50:35Z [Term] id: GO:1901319 name: positive regulation of trehalose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trehalose catabolic process." [GOC:TermGenie] synonym: "activation of mycose catabolic process" EXACT [GOC:TermGenie] synonym: "activation of mycose catabolism" EXACT [GOC:TermGenie] synonym: "activation of mykose catabolic process" EXACT [GOC:TermGenie] synonym: "activation of mykose catabolism" EXACT [GOC:TermGenie] synonym: "activation of trehalose breakdown" EXACT [GOC:TermGenie] synonym: "activation of trehalose catabolic process" NARROW [GOC:TermGenie] synonym: "activation of trehalose catabolism" EXACT [GOC:TermGenie] synonym: "activation of trehalose degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of mycose catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mycose catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mykose catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mykose catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of trehalose breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of trehalose catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of trehalose degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mycose catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mycose catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mykose catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mykose catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of trehalose breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of trehalose catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of trehalose catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of trehalose degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mycose catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mycose catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mykose catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mykose catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of trehalose breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of trehalose catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of trehalose catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of trehalose degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mycose catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mycose catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mykose catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mykose catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of trehalose breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of trehalose catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of trehalose catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of trehalose degradation" EXACT [GOC:TermGenie] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0090062 ! regulation of trehalose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005993 ! trehalose catabolic process relationship: positively_regulates GO:0005993 ! trehalose catabolic process created_by: al creation_date: 2012-08-24T12:57:52Z [Term] id: GO:1901320 name: negative regulation of heart induction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart induction." [GOC:TermGenie] synonym: "down regulation of heart induction" EXACT [GOC:TermGenie] synonym: "down-regulation of heart induction" EXACT [GOC:TermGenie] synonym: "downregulation of heart induction" EXACT [GOC:TermGenie] synonym: "inhibition of heart induction" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090381 ! regulation of heart induction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003129 ! heart induction relationship: negatively_regulates GO:0003129 ! heart induction created_by: bf creation_date: 2012-08-28T15:48:38Z [Term] id: GO:1901321 name: positive regulation of heart induction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart induction." [GOC:TermGenie] synonym: "activation of heart induction" NARROW [GOC:TermGenie] synonym: "up regulation of heart induction" EXACT [GOC:TermGenie] synonym: "up-regulation of heart induction" EXACT [GOC:TermGenie] synonym: "upregulation of heart induction" EXACT [GOC:TermGenie] is_a: GO:0090381 ! regulation of heart induction is_a: GO:0110110 ! positive regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003129 ! heart induction relationship: positively_regulates GO:0003129 ! heart induction created_by: bf creation_date: 2012-08-28T15:49:51Z [Term] id: GO:1901322 name: response to chloramphenicol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: tb creation_date: 2012-08-30T00:01:07Z [Term] id: GO:1901323 name: response to erythromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-08-30T10:09:59Z [Term] id: GO:1901324 name: response to trichodermin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2012-08-30T10:11:07Z [Term] id: GO:1901325 name: response to antimycin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-08-30T10:12:16Z [Term] id: GO:1901326 name: response to tetracycline namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie] is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2012-08-30T10:13:26Z [Term] id: GO:1901327 name: response to tacrolimus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie] synonym: "response to FK506" EXACT [CHEBI:61057] synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057] is_a: GO:0042493 ! response to drug created_by: mah creation_date: 2012-08-30T10:14:40Z [Term] id: GO:1901328 name: response to cytochalasin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie] is_a: GO:0010046 ! response to mycotoxin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-08-30T16:36:35Z [Term] id: GO:1901329 name: regulation of odontoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071895 ! odontoblast differentiation relationship: regulates GO:0071895 ! odontoblast differentiation created_by: hjd creation_date: 2012-08-31T16:50:05Z [Term] id: GO:1901330 name: negative regulation of odontoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] synonym: "down regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of odontoblast differentiation" NARROW [GOC:TermGenie] is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation is_a: GO:1901329 ! regulation of odontoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071895 ! odontoblast differentiation relationship: negatively_regulates GO:0071895 ! odontoblast differentiation created_by: hjd creation_date: 2012-08-31T16:50:27Z [Term] id: GO:1901331 name: positive regulation of odontoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] synonym: "activation of odontoblast differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of odontoblast differentiation" EXACT [GOC:TermGenie] is_a: GO:1901329 ! regulation of odontoblast differentiation is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071895 ! odontoblast differentiation relationship: positively_regulates GO:0071895 ! odontoblast differentiation created_by: hjd creation_date: 2012-08-31T16:50:35Z [Term] id: GO:1901332 name: negative regulation of lateral root development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development." [GOC:TermGenie] synonym: "down regulation of lateral root development" EXACT [GOC:TermGenie] synonym: "down-regulation of lateral root development" EXACT [GOC:TermGenie] synonym: "downregulation of lateral root development" EXACT [GOC:TermGenie] synonym: "inhibition of lateral root development" NARROW [GOC:TermGenie] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000023 ! regulation of lateral root development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048527 ! lateral root development relationship: negatively_regulates GO:0048527 ! lateral root development created_by: tb creation_date: 2012-09-01T00:58:37Z [Term] id: GO:1901333 name: positive regulation of lateral root development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral root development." [GOC:TermGenie] synonym: "activation of lateral root development" NARROW [GOC:TermGenie] synonym: "up regulation of lateral root development" EXACT [GOC:TermGenie] synonym: "up-regulation of lateral root development" EXACT [GOC:TermGenie] synonym: "upregulation of lateral root development" EXACT [GOC:TermGenie] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000023 ! regulation of lateral root development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048527 ! lateral root development relationship: positively_regulates GO:0048527 ! lateral root development created_by: tb creation_date: 2012-09-01T00:59:46Z [Term] id: GO:1901334 name: lactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactone." [GOC:TermGenie] synonym: "lactone metabolism" EXACT [GOC:TermGenie] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: bf creation_date: 2012-09-03T10:26:00Z [Term] id: GO:1901335 name: lactone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactone." [GOC:TermGenie] synonym: "lactone breakdown" EXACT [GOC:TermGenie] synonym: "lactone catabolism" EXACT [GOC:TermGenie] synonym: "lactone degradation" EXACT [GOC:TermGenie] is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901334 ! lactone metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: bf creation_date: 2012-09-03T10:27:11Z [Term] id: GO:1901336 name: lactone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactone." [GOC:TermGenie] synonym: "lactone anabolism" EXACT [GOC:TermGenie] synonym: "lactone biosynthesis" EXACT [GOC:TermGenie] synonym: "lactone formation" EXACT [GOC:TermGenie] synonym: "lactone synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901334 ! lactone metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process created_by: bf creation_date: 2012-09-03T10:27:29Z [Term] id: GO:1901337 name: thioester transport namespace: biological_process def: "The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0071702 ! organic substance transport is_a: GO:0072348 ! sulfur compound transport created_by: bf creation_date: 2012-09-03T13:14:44Z [Term] id: GO:1901338 name: catecholamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with catecholamine." [GOC:TermGenie] is_a: GO:0097159 ! organic cyclic compound binding created_by: bf creation_date: 2012-09-03T14:08:44Z [Term] id: GO:1901339 name: regulation of store-operated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015279 ! store-operated calcium channel activity relationship: regulates GO:0015279 ! store-operated calcium channel activity created_by: pr creation_date: 2012-09-03T14:23:10Z [Term] id: GO:1901340 name: negative regulation of store-operated calcium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] synonym: "down regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of store-operated calcium channel activity" NARROW [GOC:TermGenie] is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:1901339 ! regulation of store-operated calcium channel activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015279 ! store-operated calcium channel activity relationship: negatively_regulates GO:0015279 ! store-operated calcium channel activity created_by: pr creation_date: 2012-09-03T14:24:21Z [Term] id: GO:1901341 name: positive regulation of store-operated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] synonym: "activation of store-operated calcium channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:1901339 ! regulation of store-operated calcium channel activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015279 ! store-operated calcium channel activity relationship: positively_regulates GO:0015279 ! store-operated calcium channel activity created_by: pr creation_date: 2012-09-03T14:24:38Z [Term] id: GO:1901342 name: regulation of vasculature development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001944 ! vasculature development relationship: regulates GO:0001944 ! vasculature development created_by: bf creation_date: 2012-09-06T09:16:15Z [Term] id: GO:1901343 name: negative regulation of vasculature development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001944 ! vasculature development relationship: negatively_regulates GO:0001944 ! vasculature development created_by: bf creation_date: 2012-09-06T09:17:24Z [Term] id: GO:1901344 name: response to leptomycin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0070542 ! response to fatty acid created_by: mah creation_date: 2012-09-07T13:20:47Z [Term] id: GO:1901345 name: response to L-thialysine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:TermGenie] synonym: "response to thialysine" BROAD [GOC:mah] is_a: GO:0043200 ! response to amino acid created_by: mah creation_date: 2012-09-07T13:22:49Z [Term] id: GO:1901346 name: negative regulation of vasculature development involved in avascular cornea development in camera-type eye namespace: biological_process def: "Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye." [GOC:TermGenie, GOC:uh, PMID:16849433, PMID:17051153] synonym: "down regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] synonym: "down regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] synonym: "down regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] synonym: "down-regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] synonym: "down-regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] synonym: "downregulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] synonym: "downregulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] synonym: "inhibition of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development involved in avascular cornea development" NARROW [GOC:TermGenie] synonym: "inhibition of vasculature development involved in avascular cornea development in camera-type eye" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] synonym: "negative regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] synonym: "negative regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:1901343 ! negative regulation of vasculature development intersection_of: part_of GO:0036331 ! avascular cornea development in camera-type eye relationship: part_of GO:0036331 ! avascular cornea development in camera-type eye created_by: bf creation_date: 2012-09-07T15:53:40Z [Term] id: GO:1901347 name: negative regulation of secondary cell wall biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie] synonym: "down regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "down regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "down regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "down regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "down-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "down-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "down-regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "down-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "downregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "downregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "downregulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "downregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "inhibition of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "inhibition of secondary cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "inhibition of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "inhibition of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "negative regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "negative regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "negative regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "negative regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis is_a: GO:2000652 ! regulation of secondary cell wall biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis relationship: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis created_by: tb creation_date: 2012-09-07T17:58:05Z [Term] id: GO:1901348 name: positive regulation of secondary cell wall biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie] synonym: "activation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "activation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "activation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "activation of secondary cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "activation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "activation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "activation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "positive regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "positive regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "positive regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "positive regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "up regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "up regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "up regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "up regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "up-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "up-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "up-regulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "up-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] synonym: "upregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] synonym: "upregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] synonym: "upregulation of secondary cell wall formation" BROAD [GOC:TermGenie] synonym: "upregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis is_a: GO:2000652 ! regulation of secondary cell wall biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis relationship: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis created_by: tb creation_date: 2012-09-07T17:59:14Z [Term] id: GO:1901349 name: glucosinolate transport namespace: biological_process def: "The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0015711 ! organic anion transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0072348 ! sulfur compound transport is_a: GO:1901264 ! carbohydrate derivative transport created_by: tb creation_date: 2012-09-07T22:44:34Z [Term] id: GO:1901350 name: obsolete cell-cell signaling involved in cell-cell junction organization namespace: biological_process def: "OBSOLETE. Any cell-cell signaling that is involved in cell-cell junction organization." [GOC:TermGenie] comment: The reasons for obsoletion are that: (1) the term was created in 2012 and it had been used for only 1 NAS annotation (UniProt) since then; and (2)\nit can be represented as a GO-CAM. synonym: "cell-cell signaling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "cell-cell signaling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie] synonym: "cell-cell signaling involved in cell-cell junction organisation" EXACT [GOC:TermGenie] synonym: "cell-cell signaling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "cell-cell signalling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "cell-cell signalling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie] synonym: "cell-cell signalling involved in cell-cell junction organisation" EXACT [GOC:TermGenie] synonym: "cell-cell signalling involved in cell-cell junction organization" EXACT [GOC:TermGenie] synonym: "cell-cell signalling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie] is_obsolete: true created_by: rph creation_date: 2012-09-11T09:15:04Z [Term] id: GO:1901351 name: regulation of phosphatidylglycerol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] synonym: "regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process relationship: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process created_by: dgf creation_date: 2012-09-12T20:46:37Z [Term] id: GO:1901352 name: negative regulation of phosphatidylglycerol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] synonym: "down regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylglycerol formation" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process relationship: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process created_by: dgf creation_date: 2012-09-12T20:47:53Z [Term] id: GO:1901353 name: positive regulation of phosphatidylglycerol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] synonym: "activation of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylglycerol formation" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process relationship: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process created_by: dgf creation_date: 2012-09-12T20:48:11Z [Term] id: GO:1901354 name: response to L-canavanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie] is_a: GO:0017085 ! response to insecticide is_a: GO:0043200 ! response to amino acid created_by: mah creation_date: 2012-09-13T13:11:17Z [Term] id: GO:1901355 name: response to rapamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2012-09-13T13:12:26Z [Term] id: GO:1901356 name: beta-D-galactofuranose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-D-galactofuranose." [GOC:di, GOC:TermGenie] synonym: "beta-D-galactofuranose metabolism" EXACT [GOC:TermGenie] is_a: GO:0006012 ! galactose metabolic process created_by: di creation_date: 2012-09-13T22:18:20Z [Term] id: GO:1901357 name: beta-D-galactofuranose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose." [GOC:di, GOC:TermGenie] synonym: "beta-D-galactofuranose breakdown" EXACT [GOC:TermGenie] synonym: "beta-D-galactofuranose catabolism" EXACT [GOC:TermGenie] synonym: "beta-D-galactofuranose degradation" EXACT [GOC:TermGenie] is_a: GO:0019388 ! galactose catabolic process is_a: GO:1901356 ! beta-D-galactofuranose metabolic process created_by: di creation_date: 2012-09-13T22:19:30Z [Term] id: GO:1901358 name: beta-D-galactofuranose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose." [GOC:di, GOC:TermGenie] synonym: "beta-D-galactofuranose anabolism" EXACT [GOC:TermGenie] synonym: "beta-D-galactofuranose biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-D-galactofuranose formation" EXACT [GOC:TermGenie] synonym: "beta-D-galactofuranose synthesis" EXACT [GOC:TermGenie] is_a: GO:0046369 ! galactose biosynthetic process is_a: GO:1901356 ! beta-D-galactofuranose metabolic process created_by: di creation_date: 2012-09-13T22:19:47Z [Term] id: GO:1901359 name: tungstate binding namespace: molecular_function def: "Interacting selectively and non-covalently with tungstate." [GOC:TermGenie] is_a: GO:0043168 ! anion binding created_by: cdasilva creation_date: 2012-09-14T08:33:56Z [Term] id: GO:1901360 name: organic cyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: bf creation_date: 2012-09-14T09:03:51Z [Term] id: GO:1901361 name: organic cyclic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie] synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: bf creation_date: 2012-09-14T09:05:04Z [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: bf creation_date: 2012-09-14T09:05:22Z [Term] id: GO:1901363 name: heterocyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with heterocyclic compound." [GOC:TermGenie] is_a: GO:0005488 ! binding created_by: bf creation_date: 2012-09-14T13:53:50Z [Term] id: GO:1901364 name: funalenone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving funalenone." [GOC:di, GOC:TermGenie] synonym: "funalenone metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042180 ! cellular ketone metabolic process created_by: di creation_date: 2012-09-17T18:24:23Z [Term] id: GO:1901365 name: funalenone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of funalenone." [GOC:di, GOC:TermGenie] synonym: "funalenone breakdown" EXACT [GOC:TermGenie] synonym: "funalenone catabolism" EXACT [GOC:TermGenie] synonym: "funalenone degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1901364 ! funalenone metabolic process created_by: di creation_date: 2012-09-17T18:25:29Z [Term] id: GO:1901366 name: funalenone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of funalenone." [GOC:di, GOC:TermGenie] synonym: "funalenone anabolism" EXACT [GOC:TermGenie] synonym: "funalenone biosynthesis" EXACT [GOC:TermGenie] synonym: "funalenone formation" EXACT [GOC:TermGenie] synonym: "funalenone synthesis" EXACT [GOC:TermGenie] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901364 ! funalenone metabolic process created_by: di creation_date: 2012-09-17T18:25:47Z [Term] id: GO:1901367 name: response to L-cysteine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus." [GOC:TermGenie] is_a: GO:0043200 ! response to amino acid created_by: bf creation_date: 2012-09-18T13:49:42Z [Term] id: GO:1901369 name: cyclic 2,3-bisphospho-D-glycerate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid." [GOC:bf, GOC:crds, GOC:TermGenie, PMID:2226838] synonym: "cDPG biosynthesis" EXACT [PMID:2226838] synonym: "cyclic 2,3-bisphospho-D-glyceric acid anabolism" EXACT [GOC:TermGenie] synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthesis" EXACT [GOC:TermGenie] synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process" EXACT [CHEBI:28699] synonym: "cyclic 2,3-bisphospho-D-glyceric acid formation" EXACT [GOC:TermGenie] synonym: "cyclic 2,3-bisphospho-D-glyceric acid synthesis" EXACT [GOC:TermGenie] synonym: "cyclic 2,3-diphosphoglycerate biosynthesis" EXACT [CHEBI:28699] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0046175 ! aldonic acid biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process created_by: bf creation_date: 2012-09-19T14:17:57Z [Term] id: GO:1901370 name: response to glutathione namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:TermGenie] is_a: GO:1901652 ! response to peptide created_by: mah creation_date: 2012-09-21T13:59:24Z [Term] id: GO:1901371 name: regulation of leaf morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf morphogenesis." [GOC:TermGenie] is_a: GO:1900618 ! regulation of shoot system morphogenesis is_a: GO:1905421 ! regulation of plant organ morphogenesis is_a: GO:2000024 ! regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009965 ! leaf morphogenesis relationship: regulates GO:0009965 ! leaf morphogenesis created_by: tb creation_date: 2012-09-24T23:07:17Z [Term] id: GO:1901372 name: trehalose biosynthetic process involved in ascospore formation namespace: biological_process def: "Any trehalose biosynthetic process that is involved in ascospore formation." [GOC:TermGenie] synonym: "mycose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "mycose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "mycose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "mycose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "mykose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "mykose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "mykose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "mykose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "trehalose anabolism involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "trehalose anabolism involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "trehalose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "trehalose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "trehalose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "trehalose formation involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "trehalose formation involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "trehalose synthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "trehalose synthesis involved in ascospore formation" EXACT [GOC:TermGenie] is_a: GO:0005992 ! trehalose biosynthetic process is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0005992 ! trehalose biosynthetic process intersection_of: part_of GO:0030437 ! ascospore formation relationship: part_of GO:0030437 ! ascospore formation created_by: al creation_date: 2012-09-25T11:06:48Z [Term] id: GO:1901373 name: lipid hydroperoxide transport namespace: biological_process def: "The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0071702 ! organic substance transport created_by: tb creation_date: 2012-09-28T00:24:39Z [Term] id: GO:1901374 name: acetate ester transport namespace: biological_process def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0071702 ! organic substance transport created_by: bf creation_date: 2012-09-28T10:42:13Z [Term] id: GO:1901375 name: acetate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1901374 ! acetate ester transport created_by: bf creation_date: 2012-09-28T10:47:08Z [Term] id: GO:1901376 name: organic heteropentacyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic heteropentacyclic compound." [GOC:TermGenie] synonym: "organic heteropentacyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: bf creation_date: 2012-09-28T12:50:41Z [Term] id: GO:1901377 name: organic heteropentacyclic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound." [GOC:TermGenie] synonym: "organic heteropentacyclic compound breakdown" EXACT [GOC:TermGenie] synonym: "organic heteropentacyclic compound catabolism" EXACT [GOC:TermGenie] synonym: "organic heteropentacyclic compound degradation" EXACT [GOC:TermGenie] is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: bf creation_date: 2012-09-28T12:51:51Z [Term] id: GO:1901378 name: organic heteropentacyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound." [GOC:TermGenie] synonym: "organic heteropentacyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic heteropentacyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic heteropentacyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic heteropentacyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: bf creation_date: 2012-09-28T12:52:09Z [Term] id: GO:1901379 name: regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "regulation of potassium ion membrane transport" EXACT [] is_a: GO:0043266 ! regulation of potassium ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071805 ! potassium ion transmembrane transport relationship: regulates GO:0071805 ! potassium ion transmembrane transport created_by: rl creation_date: 2012-09-28T15:58:00Z [Term] id: GO:1901380 name: negative regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of potassium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of potassium ion membrane transport" EXACT [] is_a: GO:0043267 ! negative regulation of potassium ion transport is_a: GO:1901379 ! regulation of potassium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071805 ! potassium ion transmembrane transport relationship: negatively_regulates GO:0071805 ! potassium ion transmembrane transport created_by: rl creation_date: 2012-09-28T15:59:08Z [Term] id: GO:1901381 name: positive regulation of potassium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] synonym: "activation of potassium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of potassium ion membrane transport" EXACT [] synonym: "up regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0043268 ! positive regulation of potassium ion transport is_a: GO:1901379 ! regulation of potassium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071805 ! potassium ion transmembrane transport relationship: positively_regulates GO:0071805 ! potassium ion transmembrane transport created_by: rl creation_date: 2012-09-28T15:59:25Z [Term] id: GO:1901382 name: regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097360 ! chorionic trophoblast cell proliferation relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation created_by: vk creation_date: 2012-10-01T10:03:13Z [Term] id: GO:1901383 name: negative regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation created_by: vk creation_date: 2012-10-01T10:04:23Z [Term] id: GO:1901384 name: positive regulation of chorionic trophoblast cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation created_by: vk creation_date: 2012-10-01T10:04:41Z [Term] id: GO:1901385 name: regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] synonym: "regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005245 ! voltage-gated calcium channel activity relationship: regulates GO:0005245 ! voltage-gated calcium channel activity created_by: vk creation_date: 2012-10-01T10:34:08Z [Term] id: GO:1901386 name: negative regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "down regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "down regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "down-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "downregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "downregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "inhibition of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "negative regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005245 ! voltage-gated calcium channel activity relationship: negatively_regulates GO:0005245 ! voltage-gated calcium channel activity created_by: vk creation_date: 2012-10-01T10:35:15Z [Term] id: GO:1901387 name: positive regulation of voltage-gated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] synonym: "activation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "activation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "activation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "activation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "positive regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "up regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "up-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] synonym: "upregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] synonym: "upregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005245 ! voltage-gated calcium channel activity relationship: positively_regulates GO:0005245 ! voltage-gated calcium channel activity created_by: vk creation_date: 2012-10-01T10:35:32Z [Term] id: GO:1901388 name: regulation of transforming growth factor beta activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] synonym: "regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFbeta activation" EXACT [GOC:TermGenie] is_a: GO:0071634 ! regulation of transforming growth factor beta production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036363 ! transforming growth factor beta activation relationship: regulates GO:0036363 ! transforming growth factor beta activation created_by: bf creation_date: 2012-10-01T10:32:00Z [Term] id: GO:1901389 name: negative regulation of transforming growth factor beta activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] synonym: "down regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "down regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] synonym: "down-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "down-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] synonym: "downregulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "downregulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "downregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] synonym: "inhibition of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "inhibition of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGF-B activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFB activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "inhibition of transforming growth factor beta activation" NARROW [GOC:TermGenie] synonym: "negative regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "negative regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFbeta activation" EXACT [GOC:TermGenie] is_a: GO:0071635 ! negative regulation of transforming growth factor beta production is_a: GO:1901388 ! regulation of transforming growth factor beta activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036363 ! transforming growth factor beta activation relationship: negatively_regulates GO:0036363 ! transforming growth factor beta activation created_by: bf creation_date: 2012-10-01T10:33:09Z [Term] id: GO:1901390 name: positive regulation of transforming growth factor beta activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] synonym: "activation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "activation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "activation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "activation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "activation of TGFB activation" EXACT [GOC:TermGenie] synonym: "activation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "activation of transforming growth factor beta activation" NARROW [GOC:TermGenie] synonym: "positive regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "positive regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "up regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "up regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] synonym: "up-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "up-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] synonym: "upregulation of L-TGF-beta activation" EXACT [GOC:TermGenie] synonym: "upregulation of latent TGF-beta activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGF-B activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGF-beta activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFB activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFbeta activation" EXACT [GOC:TermGenie] synonym: "upregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] is_a: GO:0071636 ! positive regulation of transforming growth factor beta production is_a: GO:1901388 ! regulation of transforming growth factor beta activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036363 ! transforming growth factor beta activation relationship: positively_regulates GO:0036363 ! transforming growth factor beta activation created_by: bf creation_date: 2012-10-01T10:33:26Z [Term] id: GO:1901392 name: regulation of transforming growth factor beta1 activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] synonym: "regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] is_a: GO:0032908 ! regulation of transforming growth factor beta1 production is_a: GO:1901388 ! regulation of transforming growth factor beta activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036364 ! transforming growth factor beta1 activation relationship: regulates GO:0036364 ! transforming growth factor beta1 activation created_by: bf creation_date: 2012-10-01T10:40:06Z [Term] id: GO:1901393 name: negative regulation of transforming growth factor beta1 activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] synonym: "down regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "down regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "downregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "inhibition of transforming growth factor beta1 activation" NARROW [GOC:TermGenie] synonym: "inhibition of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] is_a: GO:0032911 ! negative regulation of transforming growth factor beta1 production is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036364 ! transforming growth factor beta1 activation relationship: negatively_regulates GO:0036364 ! transforming growth factor beta1 activation created_by: bf creation_date: 2012-10-01T10:41:17Z [Term] id: GO:1901394 name: positive regulation of transforming growth factor beta1 activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] synonym: "activation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "activation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "activation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "activation of transforming growth factor beta1 activation" NARROW [GOC:TermGenie] synonym: "activation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "up regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFB1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] synonym: "upregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] is_a: GO:0032914 ! positive regulation of transforming growth factor beta1 production is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036364 ! transforming growth factor beta1 activation relationship: positively_regulates GO:0036364 ! transforming growth factor beta1 activation created_by: bf creation_date: 2012-10-01T10:41:33Z [Term] id: GO:1901395 name: regulation of transforming growth factor beta2 activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] synonym: "regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] is_a: GO:0032909 ! regulation of transforming growth factor beta2 production is_a: GO:1901388 ! regulation of transforming growth factor beta activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036365 ! transforming growth factor beta2 activation relationship: regulates GO:0036365 ! transforming growth factor beta2 activation created_by: bf creation_date: 2012-10-01T10:46:50Z [Term] id: GO:1901396 name: negative regulation of transforming growth factor beta2 activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] synonym: "down regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "down regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "downregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "inhibition of transforming growth factor beta2 activation" NARROW [GOC:TermGenie] synonym: "negative regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] is_a: GO:0032912 ! negative regulation of transforming growth factor beta2 production is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036365 ! transforming growth factor beta2 activation relationship: negatively_regulates GO:0036365 ! transforming growth factor beta2 activation created_by: bf creation_date: 2012-10-01T10:47:59Z [Term] id: GO:1901397 name: positive regulation of transforming growth factor beta2 activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] synonym: "activation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "activation of transforming growth factor beta2 activation" NARROW [GOC:TermGenie] synonym: "positive regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "up regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFB2 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] synonym: "upregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] is_a: GO:0032915 ! positive regulation of transforming growth factor beta2 production is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036365 ! transforming growth factor beta2 activation relationship: positively_regulates GO:0036365 ! transforming growth factor beta2 activation created_by: bf creation_date: 2012-10-01T10:48:15Z [Term] id: GO:1901398 name: regulation of transforming growth factor beta3 activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] synonym: "regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] is_a: GO:0032910 ! regulation of transforming growth factor beta3 production is_a: GO:1901388 ! regulation of transforming growth factor beta activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036366 ! transforming growth factor beta3 activation relationship: regulates GO:0036366 ! transforming growth factor beta3 activation created_by: bf creation_date: 2012-10-01T10:49:25Z [Term] id: GO:1901399 name: negative regulation of transforming growth factor beta3 activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] synonym: "down regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "down regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "down regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "down-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "downregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "downregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "inhibition of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "inhibition of transforming growth factor beta3 activation" NARROW [GOC:TermGenie] synonym: "negative regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "negative regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] is_a: GO:0032913 ! negative regulation of transforming growth factor beta3 production is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036366 ! transforming growth factor beta3 activation relationship: negatively_regulates GO:0036366 ! transforming growth factor beta3 activation created_by: bf creation_date: 2012-10-01T10:50:32Z [Term] id: GO:1901400 name: positive regulation of transforming growth factor beta3 activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] synonym: "activation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "activation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "activation of transforming growth factor beta3 activation" NARROW [GOC:TermGenie] synonym: "positive regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "positive regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "up regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "up regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "up-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFB3 activation" EXACT [GOC:TermGenie] synonym: "upregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] synonym: "upregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] is_a: GO:0032916 ! positive regulation of transforming growth factor beta3 production is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036366 ! transforming growth factor beta3 activation relationship: positively_regulates GO:0036366 ! transforming growth factor beta3 activation created_by: bf creation_date: 2012-10-01T10:50:49Z [Term] id: GO:1901401 name: regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033013 ! tetrapyrrole metabolic process relationship: regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:34:03Z [Term] id: GO:1901402 name: negative regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:11Z [Term] id: GO:1901403 name: positive regulation of tetrapyrrole metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033013 ! tetrapyrrole metabolic process relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:29Z [Term] id: GO:1901404 name: regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033015 ! tetrapyrrole catabolic process relationship: regulates GO:0033015 ! tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:38:12Z [Term] id: GO:1901405 name: negative regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:39:22Z [Term] id: GO:1901406 name: positive regulation of tetrapyrrole catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033015 ! tetrapyrrole catabolic process relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process created_by: tt creation_date: 2012-10-01T14:39:40Z [Term] id: GO:1901407 name: regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:39:50Z [Term] id: GO:1901408 name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "down regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "downregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "downregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "inhibition of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "inhibition of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] synonym: "negative regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:40:58Z [Term] id: GO:1901409 name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] synonym: "activation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "activation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "activation of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] synonym: "positive regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "upregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] synonym: "upregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain relationship: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain created_by: vw creation_date: 2012-10-01T14:41:15Z [Term] id: GO:1901410 name: regulation of tetrapyrrole biosynthetic process from glutamate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate relationship: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate created_by: tt creation_date: 2012-10-01T16:20:56Z [Term] id: GO:1901411 name: negative regulation of tetrapyrrole biosynthetic process from glutamate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process is_a: GO:2000212 ! negative regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate relationship: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate created_by: tt creation_date: 2012-10-01T16:22:03Z [Term] id: GO:1901412 name: positive regulation of tetrapyrrole biosynthetic process from glutamate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process is_a: GO:2000213 ! positive regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate relationship: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate created_by: tt creation_date: 2012-10-01T16:22:21Z [Term] id: GO:1901413 name: regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA relationship: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA created_by: tt creation_date: 2012-10-01T16:27:43Z [Term] id: GO:1901414 name: negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA relationship: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA created_by: tt creation_date: 2012-10-01T16:28:54Z [Term] id: GO:1901415 name: positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA relationship: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA created_by: tt creation_date: 2012-10-01T16:29:12Z [Term] id: GO:1901416 name: regulation of response to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1901419 ! regulation of response to alcohol is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045471 ! response to ethanol relationship: regulates GO:0045471 ! response to ethanol created_by: tt creation_date: 2012-10-01T16:48:24Z [Term] id: GO:1901417 name: negative regulation of response to ethanol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie] is_a: GO:1901416 ! regulation of response to ethanol is_a: GO:1901420 ! negative regulation of response to alcohol is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045471 ! response to ethanol relationship: negatively_regulates GO:0045471 ! response to ethanol created_by: tt creation_date: 2012-10-01T16:49:33Z [Term] id: GO:1901418 name: positive regulation of response to ethanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to ethanol" NARROW [GOC:TermGenie] synonym: "up regulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie] is_a: GO:1901416 ! regulation of response to ethanol is_a: GO:1901421 ! positive regulation of response to alcohol is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045471 ! response to ethanol relationship: positively_regulates GO:0045471 ! response to ethanol created_by: tt creation_date: 2012-10-01T16:49:51Z [Term] id: GO:1901419 name: regulation of response to alcohol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097305 ! response to alcohol relationship: regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:52:13Z [Term] id: GO:1901420 name: negative regulation of response to alcohol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097305 ! response to alcohol relationship: negatively_regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:53:25Z [Term] id: GO:1901421 name: positive regulation of response to alcohol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to alcohol" NARROW [GOC:TermGenie] synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie] synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097305 ! response to alcohol relationship: positively_regulates GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T16:53:42Z [Term] id: GO:1901422 name: response to butan-1-ol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T17:03:54Z [Term] id: GO:1901423 name: response to benzene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound created_by: tt creation_date: 2012-10-01T18:35:11Z [Term] id: GO:1901424 name: response to toluene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0009636 ! response to toxic substance is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug created_by: tt creation_date: 2012-10-01T18:38:32Z [Term] id: GO:1901425 name: response to formic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: tt creation_date: 2012-10-01T18:43:05Z [Term] id: GO:1901426 name: response to furfural namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: tt creation_date: 2012-10-01T18:45:43Z [Term] id: GO:1901427 name: response to propan-1-ol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T18:55:48Z [Term] id: GO:1901428 name: regulation of syringal lignin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] synonym: "regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:1901141 ! regulation of lignin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901066 ! syringal lignin biosynthetic process relationship: regulates GO:1901066 ! syringal lignin biosynthetic process created_by: tb creation_date: 2012-10-01T20:13:41Z [Term] id: GO:1901429 name: negative regulation of syringal lignin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] synonym: "down regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process relationship: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process created_by: tb creation_date: 2012-10-01T20:14:51Z [Term] id: GO:1901430 name: positive regulation of syringal lignin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] synonym: "activation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin formation" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901066 ! syringal lignin biosynthetic process relationship: positively_regulates GO:1901066 ! syringal lignin biosynthetic process created_by: tb creation_date: 2012-10-01T20:15:09Z [Term] id: GO:1901431 name: regulation of response to cycloalkane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014071 ! response to cycloalkane relationship: regulates GO:0014071 ! response to cycloalkane created_by: tt creation_date: 2012-10-01T21:01:58Z [Term] id: GO:1901432 name: negative regulation of response to cycloalkane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to cycloalkane" EXACT [GOC:TermGenie] synonym: "down-regulation of response to cycloalkane" EXACT [GOC:TermGenie] synonym: "downregulation of response to cycloalkane" EXACT [GOC:TermGenie] synonym: "inhibition of response to cycloalkane" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901431 ! regulation of response to cycloalkane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014071 ! response to cycloalkane relationship: negatively_regulates GO:0014071 ! response to cycloalkane created_by: tt creation_date: 2012-10-01T21:03:08Z [Term] id: GO:1901433 name: positive regulation of response to cycloalkane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to cycloalkane" NARROW [GOC:TermGenie] synonym: "up regulation of response to cycloalkane" EXACT [GOC:TermGenie] synonym: "up-regulation of response to cycloalkane" EXACT [GOC:TermGenie] synonym: "upregulation of response to cycloalkane" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901431 ! regulation of response to cycloalkane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014071 ! response to cycloalkane relationship: positively_regulates GO:0014071 ! response to cycloalkane created_by: tt creation_date: 2012-10-01T21:03:26Z [Term] id: GO:1901434 name: regulation of toluene catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "regulation of toluene degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:1901437 ! regulation of toluene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042203 ! toluene catabolic process relationship: regulates GO:0042203 ! toluene catabolic process created_by: tt creation_date: 2012-10-01T21:12:31Z [Term] id: GO:1901435 name: negative regulation of toluene catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "downregulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "inhibition of toluene breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of toluene catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of toluene catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of toluene degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of toluene degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901434 ! regulation of toluene catabolic process is_a: GO:1901438 ! negative regulation of toluene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042203 ! toluene catabolic process relationship: negatively_regulates GO:0042203 ! toluene catabolic process created_by: tt creation_date: 2012-10-01T21:13:41Z [Term] id: GO:1901436 name: positive regulation of toluene catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "activation of toluene catabolic process" NARROW [GOC:TermGenie] synonym: "activation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "activation of toluene degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "up regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene degradation" EXACT [GOC:TermGenie] synonym: "upregulation of toluene breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of toluene catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of toluene catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of toluene degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901434 ! regulation of toluene catabolic process is_a: GO:1901439 ! positive regulation of toluene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042203 ! toluene catabolic process relationship: positively_regulates GO:0042203 ! toluene catabolic process created_by: tt creation_date: 2012-10-01T21:13:57Z [Term] id: GO:1901437 name: regulation of toluene metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "regulation of toluene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018970 ! toluene metabolic process relationship: regulates GO:0018970 ! toluene metabolic process created_by: tt creation_date: 2012-10-01T21:17:41Z [Term] id: GO:1901438 name: negative regulation of toluene metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of toluene metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of toluene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of toluene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1901437 ! regulation of toluene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018970 ! toluene metabolic process relationship: negatively_regulates GO:0018970 ! toluene metabolic process created_by: tt creation_date: 2012-10-01T21:18:50Z [Term] id: GO:1901439 name: positive regulation of toluene metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "activation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "activation of toluene metabolic process" NARROW [GOC:TermGenie] synonym: "activation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of toluene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of methylbenzene metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of toluene metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of toluene metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1901437 ! regulation of toluene metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018970 ! toluene metabolic process relationship: positively_regulates GO:0018970 ! toluene metabolic process created_by: tt creation_date: 2012-10-01T21:19:08Z [Term] id: GO:1901440 name: poly(hydroxyalkanoate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie] synonym: "poly(hydroxyalkanoate) metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: tt creation_date: 2012-10-02T01:47:26Z [Term] id: GO:1901441 name: poly(hydroxyalkanoate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie] synonym: "poly(hydroxyalkanoate) anabolism" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) formation" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) synthesis" EXACT [GOC:TermGenie] is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: tt creation_date: 2012-10-02T01:48:33Z [Term] id: GO:1901442 name: regulation of response to furfural namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901426 ! response to furfural relationship: regulates GO:1901426 ! response to furfural created_by: tt creation_date: 2012-10-02T14:09:26Z [Term] id: GO:1901443 name: negative regulation of response to furfural namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to furfural" EXACT [GOC:TermGenie] synonym: "down-regulation of response to furfural" EXACT [GOC:TermGenie] synonym: "downregulation of response to furfural" EXACT [GOC:TermGenie] synonym: "inhibition of response to furfural" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901442 ! regulation of response to furfural intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901426 ! response to furfural relationship: negatively_regulates GO:1901426 ! response to furfural created_by: tt creation_date: 2012-10-02T14:10:34Z [Term] id: GO:1901444 name: positive regulation of response to furfural namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to furfural" NARROW [GOC:TermGenie] synonym: "up regulation of response to furfural" EXACT [GOC:TermGenie] synonym: "up-regulation of response to furfural" EXACT [GOC:TermGenie] synonym: "upregulation of response to furfural" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901442 ! regulation of response to furfural intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901426 ! response to furfural relationship: positively_regulates GO:1901426 ! response to furfural created_by: tt creation_date: 2012-10-02T14:10:51Z [Term] id: GO:1901445 name: regulation of response to propan-1-ol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901427 ! response to propan-1-ol relationship: regulates GO:1901427 ! response to propan-1-ol created_by: tt creation_date: 2012-10-02T14:12:46Z [Term] id: GO:1901446 name: negative regulation of response to propan-1-ol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to propan-1-ol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to propan-1-ol" EXACT [GOC:TermGenie] synonym: "downregulation of response to propan-1-ol" EXACT [GOC:TermGenie] synonym: "inhibition of response to propan-1-ol" NARROW [GOC:TermGenie] is_a: GO:1901420 ! negative regulation of response to alcohol is_a: GO:1901445 ! regulation of response to propan-1-ol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901427 ! response to propan-1-ol relationship: negatively_regulates GO:1901427 ! response to propan-1-ol created_by: tt creation_date: 2012-10-02T14:13:52Z [Term] id: GO:1901447 name: positive regulation of response to propan-1-ol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to propan-1-ol" NARROW [GOC:TermGenie] synonym: "up regulation of response to propan-1-ol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to propan-1-ol" EXACT [GOC:TermGenie] synonym: "upregulation of response to propan-1-ol" EXACT [GOC:TermGenie] is_a: GO:1901421 ! positive regulation of response to alcohol is_a: GO:1901445 ! regulation of response to propan-1-ol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901427 ! response to propan-1-ol relationship: positively_regulates GO:1901427 ! response to propan-1-ol created_by: tt creation_date: 2012-10-02T14:14:10Z [Term] id: GO:1901448 name: regulation of response to butan-1-ol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901422 ! response to butan-1-ol relationship: regulates GO:1901422 ! response to butan-1-ol created_by: tt creation_date: 2012-10-02T14:15:50Z [Term] id: GO:1901449 name: negative regulation of response to butan-1-ol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to butan-1-ol" EXACT [GOC:TermGenie] synonym: "down-regulation of response to butan-1-ol" EXACT [GOC:TermGenie] synonym: "downregulation of response to butan-1-ol" EXACT [GOC:TermGenie] synonym: "inhibition of response to butan-1-ol" NARROW [GOC:TermGenie] is_a: GO:1901420 ! negative regulation of response to alcohol is_a: GO:1901448 ! regulation of response to butan-1-ol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901422 ! response to butan-1-ol relationship: negatively_regulates GO:1901422 ! response to butan-1-ol created_by: tt creation_date: 2012-10-02T14:16:59Z [Term] id: GO:1901450 name: positive regulation of response to butan-1-ol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to butan-1-ol" NARROW [GOC:TermGenie] synonym: "up regulation of response to butan-1-ol" EXACT [GOC:TermGenie] synonym: "up-regulation of response to butan-1-ol" EXACT [GOC:TermGenie] synonym: "upregulation of response to butan-1-ol" EXACT [GOC:TermGenie] is_a: GO:1901421 ! positive regulation of response to alcohol is_a: GO:1901448 ! regulation of response to butan-1-ol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901422 ! response to butan-1-ol relationship: positively_regulates GO:1901422 ! response to butan-1-ol created_by: tt creation_date: 2012-10-02T14:17:17Z [Term] id: GO:1901451 name: regulation of response to benzene namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901423 ! response to benzene relationship: regulates GO:1901423 ! response to benzene created_by: tt creation_date: 2012-10-02T14:19:10Z [Term] id: GO:1901452 name: negative regulation of response to benzene namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to benzene" EXACT [GOC:TermGenie] synonym: "down-regulation of response to benzene" EXACT [GOC:TermGenie] synonym: "downregulation of response to benzene" EXACT [GOC:TermGenie] synonym: "inhibition of response to benzene" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901451 ! regulation of response to benzene intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901423 ! response to benzene relationship: negatively_regulates GO:1901423 ! response to benzene created_by: tt creation_date: 2012-10-02T14:20:23Z [Term] id: GO:1901453 name: positive regulation of response to benzene namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to benzene" NARROW [GOC:TermGenie] synonym: "up regulation of response to benzene" EXACT [GOC:TermGenie] synonym: "up-regulation of response to benzene" EXACT [GOC:TermGenie] synonym: "upregulation of response to benzene" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901451 ! regulation of response to benzene intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901423 ! response to benzene relationship: positively_regulates GO:1901423 ! response to benzene created_by: tt creation_date: 2012-10-02T14:20:41Z [Term] id: GO:1901454 name: regulation of response to toluene namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901424 ! response to toluene relationship: regulates GO:1901424 ! response to toluene created_by: tt creation_date: 2012-10-02T14:22:17Z [Term] id: GO:1901455 name: negative regulation of response to toluene namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie] synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie] is_a: GO:1901454 ! regulation of response to toluene is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901424 ! response to toluene relationship: negatively_regulates GO:1901424 ! response to toluene created_by: tt creation_date: 2012-10-02T14:23:28Z [Term] id: GO:1901456 name: positive regulation of response to toluene namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to toluene" NARROW [GOC:TermGenie] synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie] is_a: GO:1901454 ! regulation of response to toluene is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901424 ! response to toluene relationship: positively_regulates GO:1901424 ! response to toluene created_by: tt creation_date: 2012-10-02T14:23:45Z [Term] id: GO:1901457 name: regulation of response to acetate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010034 ! response to acetate relationship: regulates GO:0010034 ! response to acetate created_by: tt creation_date: 2012-10-02T14:25:06Z [Term] id: GO:1901458 name: negative regulation of response to acetate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie] synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901457 ! regulation of response to acetate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010034 ! response to acetate relationship: negatively_regulates GO:0010034 ! response to acetate created_by: tt creation_date: 2012-10-02T14:26:15Z [Term] id: GO:1901459 name: positive regulation of response to acetate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to acetate" NARROW [GOC:TermGenie] synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie] synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901457 ! regulation of response to acetate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010034 ! response to acetate relationship: positively_regulates GO:0010034 ! response to acetate created_by: tt creation_date: 2012-10-02T14:26:34Z [Term] id: GO:1901460 name: regulation of response to formic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901425 ! response to formic acid relationship: regulates GO:1901425 ! response to formic acid created_by: tt creation_date: 2012-10-02T14:27:54Z [Term] id: GO:1901461 name: negative regulation of response to formic acid namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie] is_a: GO:1901460 ! regulation of response to formic acid is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901425 ! response to formic acid relationship: negatively_regulates GO:1901425 ! response to formic acid created_by: tt creation_date: 2012-10-02T14:29:02Z [Term] id: GO:1901462 name: positive regulation of response to formic acid namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of response to formic acid" NARROW [GOC:TermGenie] synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie] is_a: GO:1901460 ! regulation of response to formic acid is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901425 ! response to formic acid relationship: positively_regulates GO:1901425 ! response to formic acid created_by: tt creation_date: 2012-10-02T14:29:20Z [Term] id: GO:1901463 name: regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033014 ! tetrapyrrole biosynthetic process relationship: regulates GO:0033014 ! tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:34:14Z [Term] id: GO:1901464 name: negative regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process relationship: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:35:26Z [Term] id: GO:1901465 name: positive regulation of tetrapyrrole biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process relationship: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process created_by: tt creation_date: 2012-10-02T14:35:43Z [Term] id: GO:1901466 name: regulation of ferulate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ferulate degradation" EXACT [GOC:TermGenie] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901067 ! ferulate catabolic process relationship: regulates GO:1901067 ! ferulate catabolic process created_by: tt creation_date: 2012-10-02T14:37:29Z [Term] id: GO:1901467 name: negative regulation of ferulate catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "downregulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "inhibition of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of ferulate catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ferulate degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ferulate degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1901466 ! regulation of ferulate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901067 ! ferulate catabolic process relationship: negatively_regulates GO:1901067 ! ferulate catabolic process created_by: tt creation_date: 2012-10-02T14:38:38Z [Term] id: GO:1901468 name: positive regulation of ferulate catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "activation of ferulate catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "activation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "up regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ferulate degradation" EXACT [GOC:TermGenie] synonym: "upregulation of ferulate breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ferulate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ferulate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ferulate degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1901466 ! regulation of ferulate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901067 ! ferulate catabolic process relationship: positively_regulates GO:1901067 ! ferulate catabolic process created_by: tt creation_date: 2012-10-02T14:38:56Z [Term] id: GO:1901469 name: regulation of syringal lignin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "regulation of syringal lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901065 ! syringal lignin catabolic process relationship: regulates GO:1901065 ! syringal lignin catabolic process created_by: tt creation_date: 2012-10-02T14:41:12Z [Term] id: GO:1901470 name: negative regulation of syringal lignin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "down regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "downregulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "inhibition of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of syringal lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:1901469 ! regulation of syringal lignin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901065 ! syringal lignin catabolic process relationship: negatively_regulates GO:1901065 ! syringal lignin catabolic process created_by: tt creation_date: 2012-10-02T14:42:21Z [Term] id: GO:1901471 name: positive regulation of syringal lignin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] synonym: "activation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin catabolic process" NARROW [GOC:TermGenie] synonym: "activation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "activation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "up regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of syringal lignin degradation" EXACT [GOC:TermGenie] synonym: "upregulation of S-lignin catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of syringal lignin degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:1901469 ! regulation of syringal lignin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901065 ! syringal lignin catabolic process relationship: positively_regulates GO:1901065 ! syringal lignin catabolic process created_by: tt creation_date: 2012-10-02T14:42:39Z [Term] id: GO:1901472 name: regulation of Golgi calcium ion export namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi relationship: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi created_by: al creation_date: 2012-10-03T07:26:03Z [Term] id: GO:1901474 name: azole transmembrane transporter activity namespace: molecular_function alt_id: GO:0045118 def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] synonym: "azole transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0045117 ! azole transmembrane transport created_by: tb creation_date: 2012-10-04T20:00:27Z [Term] id: GO:1901475 name: pyruvate transmembrane transport namespace: biological_process def: "The directed movement of pyruvate across a membrane." [GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pyruvate membrane transport" EXACT [] is_a: GO:0006848 ! pyruvate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: tb creation_date: 2012-10-04T20:52:54Z [Term] id: GO:1901477 name: benomyl transmembrane transport namespace: biological_process def: "The directed movement of benomyl across a membrane." [GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "benomyl membrane transport" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015900 ! benomyl transport created_by: tb creation_date: 2012-10-04T23:11:36Z [Term] id: GO:1901478 name: aminotriazole transmembrane transporter activity namespace: molecular_function alt_id: GO:0015241 def: "Enables the transfer of amitrole from one side of a membrane to the other." [GOC:TermGenie] synonym: "aminotriazole transporter activity" BROAD [] is_a: GO:1901474 ! azole transmembrane transporter activity created_by: tb creation_date: 2012-10-04T23:21:06Z [Term] id: GO:1901479 name: benomyl transmembrane transporter activity namespace: molecular_function alt_id: GO:0015242 def: "Enables the transfer of benomyl from one side of a membrane to the other." [GOC:TermGenie] synonym: "benomyl transporter activity" RELATED [] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity relationship: part_of GO:1901477 ! benomyl transmembrane transport created_by: tb creation_date: 2012-10-04T23:21:10Z [Term] id: GO:1901480 name: oleate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oleate from one side of a membrane to the other." [GOC:TermGenie, PMID:19493158, RHEA:33655] synonym: "oleate transporter activity" RELATED [] is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015245 ! fatty acid transmembrane transporter activity created_by: ab creation_date: 2012-10-07T17:11:56Z [Term] id: GO:1901481 name: L-glutamate import involved in cellular response to nitrogen starvation namespace: biological_process def: "Any L-glutamate import that is involved in cellular response to nitrogen starvation." [GOC:TermGenie] synonym: "L-glutamate uptake involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie] is_a: GO:0051938 ! L-glutamate import intersection_of: GO:0051938 ! L-glutamate import intersection_of: part_of GO:0006995 ! cellular response to nitrogen starvation relationship: part_of GO:0006995 ! cellular response to nitrogen starvation created_by: al creation_date: 2012-10-08T08:32:29Z [Term] id: GO:1901482 name: L-lysine import into vacuole involved in cellular response to nitrogen starvation namespace: biological_process def: "A L-lysine import into the vacuole that is involved in cellular response to nitrogen starvation." [GOC:TermGenie] is_a: GO:0090517 ! L-lysine transmembrane import into vacuole relationship: part_of GO:0006995 ! cellular response to nitrogen starvation created_by: al creation_date: 2012-10-08T08:34:03Z [Term] id: GO:1901483 name: regulation of transcription factor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559] synonym: "regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "regulation of transcription factor degradation" EXACT [GOC:TermGenie] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036369 ! transcription factor catabolic process relationship: regulates GO:0036369 ! transcription factor catabolic process created_by: bf creation_date: 2012-10-08T09:03:18Z [Term] id: GO:1901484 name: negative regulation of transcription factor catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw] synonym: "down regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "inhibition of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of transcription factor catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription factor degradation" EXACT [GOC:TermGenie] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901483 ! regulation of transcription factor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036369 ! transcription factor catabolic process relationship: negatively_regulates GO:0036369 ! transcription factor catabolic process created_by: bf creation_date: 2012-10-08T09:03:22Z [Term] id: GO:1901485 name: positive regulation of transcription factor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559] synonym: "activation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "activation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "activation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "activation of transcription factor catabolic process" NARROW [GOC:TermGenie] synonym: "activation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "activation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription factor degradation" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of transcription factor breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of transcription factor catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of transcription factor degradation" EXACT [GOC:TermGenie] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901483 ! regulation of transcription factor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036369 ! transcription factor catabolic process relationship: positively_regulates GO:0036369 ! transcription factor catabolic process created_by: bf creation_date: 2012-10-08T09:03:27Z [Term] id: GO:1901486 name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process namespace: biological_process def: "OBSOLETE. Positive regulation of transcription factor catabolism that results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation" NARROW [GOC:bf] synonym: "negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolism" EXACT [GOC:bf] synonym: "negative regulation of SREBP-mediated signaling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signalling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-10-09T08:23:26Z [Term] id: GO:1901487 name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels namespace: biological_process def: "OBSOLETE. Positive regulation of transcription factor catabolism in response to increased oxygen levels, which results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] comment: The reason for obsoletion is that this is better captured in a GO-CAM model. See https://github.com/geneontology/go-ontology/issues/14544 synonym: "negative regulation of SREBP signaling by acceleration of SREBP degradation, in response to increased oxygen levels" NARROW [PMID:22833559] synonym: "negative regulation of SREBP signaling by positive regulation of transcription factor catabolism in response to increased oxygen levels" EXACT [GOC:bf] synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation, in response to elevated oxygen" NARROW [GOC:bf] synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen by positive regulation of transcription factor catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-10-09T08:23:33Z [Term] id: GO:1901488 name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process namespace: biological_process def: "OBSOLETE. Negative regulation of transcription factor catabolism that results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. synonym: "positive regulation of SREBP signaling pathway by inhibition of SREBP degradation" NARROW [PMID:22833559] synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation" NARROW [PMID:22833559] synonym: "positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolism" EXACT [GOC:bf] synonym: "positive regulation of SREBP-mediated signaling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of SREBP-mediated signalling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-10-09T08:23:43Z [Term] id: GO:1901489 name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process in response to decreased oxygen levels namespace: biological_process def: "OBSOLETE. Negative regulation of transcription factor catabolism in response to decreased oxygen levels, which results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. synonym: "positive regulation of SREBP signaling by inhibition of SREBP degradation in response to decreased oxygen levels" EXACT [GOC:bf] synonym: "positive regulation of SREBP signaling by negative regulation of transcription factor catabolism at low oxygen levels" EXACT [GOC:bf] synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation, in response to decreased oxygen" NARROW [PMID:22833559] synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen by negative regulation of transcription factor catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] is_obsolete: true created_by: bf creation_date: 2012-10-09T08:23:50Z [Term] id: GO:1901490 name: regulation of lymphangiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "regulation of lymph vessel formation" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001946 ! lymphangiogenesis relationship: regulates GO:0001946 ! lymphangiogenesis created_by: dph creation_date: 2012-10-15T13:08:17Z [Term] id: GO:1901491 name: negative regulation of lymphangiogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "down regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "down regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "downregulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of lymph vessel formation" NARROW [GOC:TermGenie] synonym: "inhibition of lymphangiogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of lymph vessel formation" EXACT [GOC:TermGenie] is_a: GO:1901343 ! negative regulation of vasculature development is_a: GO:1901490 ! regulation of lymphangiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001946 ! lymphangiogenesis relationship: negatively_regulates GO:0001946 ! lymphangiogenesis created_by: dph creation_date: 2012-10-15T13:08:21Z [Term] id: GO:1901492 name: positive regulation of lymphangiogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] synonym: "activation of lymph vessel formation" NARROW [GOC:TermGenie] synonym: "activation of lymphangiogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of lymph vessel formation" EXACT [GOC:TermGenie] synonym: "upregulation of lymphangiogenesis" EXACT [GOC:TermGenie] is_a: GO:1901490 ! regulation of lymphangiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001946 ! lymphangiogenesis relationship: positively_regulates GO:0001946 ! lymphangiogenesis created_by: dph creation_date: 2012-10-15T13:08:25Z [Term] id: GO:1901493 name: response to decalin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound created_by: tt creation_date: 2012-10-16T13:41:09Z [Term] id: GO:1901494 name: regulation of cysteine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] synonym: "regulation of cysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006534 ! cysteine metabolic process relationship: regulates GO:0006534 ! cysteine metabolic process created_by: vw creation_date: 2012-10-16T14:28:42Z [Term] id: GO:1901495 name: negative regulation of cysteine metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] synonym: "down regulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of cysteine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cysteine metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of cysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process is_a: GO:1901494 ! regulation of cysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006534 ! cysteine metabolic process relationship: negatively_regulates GO:0006534 ! cysteine metabolic process created_by: vw creation_date: 2012-10-16T14:28:47Z [Term] id: GO:1901496 name: positive regulation of cysteine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] synonym: "activation of cysteine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of cysteine metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cysteine metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cysteine metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process is_a: GO:1901494 ! regulation of cysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006534 ! cysteine metabolic process relationship: positively_regulates GO:0006534 ! cysteine metabolic process created_by: vw creation_date: 2012-10-16T14:28:51Z [Term] id: GO:1901497 name: response to diphenyl ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether created_by: tt creation_date: 2012-10-16T14:58:08Z [Term] id: GO:1901498 name: response to tetralin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound created_by: tt creation_date: 2012-10-16T15:10:22Z [Term] id: GO:1901499 name: response to hexane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0009636 ! response to toxic substance is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2012-10-16T15:14:49Z [Term] id: GO:1901500 name: response to p-xylene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1901501 ! response to xylene created_by: tt creation_date: 2012-10-16T15:23:54Z [Term] id: GO:1901501 name: response to xylene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound created_by: tt creation_date: 2012-10-16T15:25:47Z [Term] id: GO:1901502 name: ether catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ether." [GOC:pr, GOC:TermGenie] synonym: "ether breakdown" EXACT [GOC:TermGenie] synonym: "ether catabolism" EXACT [GOC:TermGenie] synonym: "ether degradation" EXACT [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: pr creation_date: 2012-10-17T09:42:43Z [Term] id: GO:1901503 name: ether biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie] synonym: "ether anabolism" EXACT [GOC:TermGenie] synonym: "ether biosynthesis" EXACT [GOC:TermGenie] synonym: "ether formation" EXACT [GOC:TermGenie] synonym: "ether synthesis" EXACT [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-10-17T09:42:47Z [Term] id: GO:1901504 name: triazole transport namespace: biological_process def: "The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport created_by: pr creation_date: 2012-10-17T09:47:46Z [Term] id: GO:1901505 name: carbohydrate derivative transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "carbohydrate derivative transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:1901264 ! carbohydrate derivative transport created_by: pr creation_date: 2012-10-17T10:31:22Z [Term] id: GO:1901506 name: regulation of acylglycerol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] synonym: "regulation of glyceride transport" EXACT [GOC:TermGenie] is_a: GO:0032368 ! regulation of lipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034196 ! acylglycerol transport relationship: regulates GO:0034196 ! acylglycerol transport created_by: sart creation_date: 2012-10-17T11:06:10Z [Term] id: GO:1901507 name: negative regulation of acylglycerol transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] synonym: "down regulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "down regulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "down-regulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "down-regulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "downregulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "downregulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "inhibition of acylglycerol transport" NARROW [GOC:TermGenie] synonym: "inhibition of glyceride transport" NARROW [GOC:TermGenie] synonym: "negative regulation of glyceride transport" EXACT [GOC:TermGenie] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:1901506 ! regulation of acylglycerol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034196 ! acylglycerol transport relationship: negatively_regulates GO:0034196 ! acylglycerol transport created_by: sart creation_date: 2012-10-17T11:06:18Z [Term] id: GO:1901508 name: positive regulation of acylglycerol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] synonym: "activation of acylglycerol transport" NARROW [GOC:TermGenie] synonym: "activation of glyceride transport" NARROW [GOC:TermGenie] synonym: "positive regulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "up regulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "up regulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "up-regulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "up-regulation of glyceride transport" EXACT [GOC:TermGenie] synonym: "upregulation of acylglycerol transport" EXACT [GOC:TermGenie] synonym: "upregulation of glyceride transport" EXACT [GOC:TermGenie] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:1901506 ! regulation of acylglycerol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034196 ! acylglycerol transport relationship: positively_regulates GO:0034196 ! acylglycerol transport created_by: sart creation_date: 2012-10-17T11:06:23Z [Term] id: GO:1901509 name: regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061154 ! endothelial tube morphogenesis relationship: regulates GO:0061154 ! endothelial tube morphogenesis created_by: dph creation_date: 2012-10-17T14:30:40Z [Term] id: GO:1901510 name: (-)-microperfuranone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-microperfuranone." [GOC:di, GOC:TermGenie] synonym: "(-)-microperfuranone metabolism" EXACT [GOC:TermGenie] is_a: GO:0018904 ! ether metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: di creation_date: 2012-10-18T06:54:10Z [Term] id: GO:1901511 name: (-)-microperfuranone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone." [GOC:di, GOC:TermGenie] synonym: "(-)-microperfuranone breakdown" EXACT [GOC:TermGenie] synonym: "(-)-microperfuranone catabolism" EXACT [GOC:TermGenie] synonym: "(-)-microperfuranone degradation" EXACT [GOC:TermGenie] is_a: GO:1901335 ! lactone catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901510 ! (-)-microperfuranone metabolic process created_by: di creation_date: 2012-10-18T06:54:14Z [Term] id: GO:1901512 name: (-)-microperfuranone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-microperfuranone." [GOC:di, GOC:TermGenie] synonym: "(-)-microperfuranone anabolism" EXACT [GOC:TermGenie] synonym: "(-)-microperfuranone biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-microperfuranone formation" EXACT [GOC:TermGenie] synonym: "(-)-microperfuranone synthesis" EXACT [GOC:TermGenie] is_a: GO:1901336 ! lactone biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901510 ! (-)-microperfuranone metabolic process created_by: di creation_date: 2012-10-18T06:54:18Z [Term] id: GO:1901513 name: lipo-chitin oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity created_by: jl creation_date: 2012-10-18T11:52:51Z [Term] id: GO:1901514 name: ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)." [GOC:TermGenie] synonym: "lipo-chitin oligosaccharide transmembrane-transporting ATPase activity" RELATED [] is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:1901513 ! lipo-chitin oligosaccharide transmembrane transporter activity created_by: jl creation_date: 2012-10-18T11:52:55Z [Term] id: GO:1901515 name: poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other." [GOC:TermGenie, PMID:15090514, PMID:18359807] is_a: GO:0022857 ! transmembrane transporter activity created_by: jl creation_date: 2012-10-18T11:57:04Z [Term] id: GO:1901516 name: aspyridone A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspyridone A." [GOC:di, GOC:TermGenie] synonym: "aspyridone A metabolism" EXACT [GOC:TermGenie] is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: di creation_date: 2012-10-18T18:31:28Z [Term] id: GO:1901517 name: aspyridone A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspyridone A." [GOC:di, GOC:TermGenie] synonym: "aspyridone A breakdown" EXACT [GOC:TermGenie] synonym: "aspyridone A catabolism" EXACT [GOC:TermGenie] synonym: "aspyridone A degradation" EXACT [GOC:TermGenie] is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process is_a: GO:1901516 ! aspyridone A metabolic process created_by: di creation_date: 2012-10-18T18:31:32Z [Term] id: GO:1901518 name: aspyridone A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspyridone A." [GOC:di, GOC:TermGenie] synonym: "aspyridone A anabolism" EXACT [GOC:TermGenie] synonym: "aspyridone A biosynthesis" EXACT [GOC:TermGenie] synonym: "aspyridone A formation" EXACT [GOC:TermGenie] synonym: "aspyridone A synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:1901516 ! aspyridone A metabolic process created_by: di creation_date: 2012-10-18T18:31:36Z [Term] id: GO:1901519 name: aspyridone B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspyridone B." [GOC:di, GOC:TermGenie] synonym: "aspyridone B metabolism" EXACT [GOC:TermGenie] is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: di creation_date: 2012-10-18T18:31:40Z [Term] id: GO:1901520 name: aspyridone B catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspyridone B." [GOC:di, GOC:TermGenie] synonym: "aspyridone B breakdown" EXACT [GOC:TermGenie] synonym: "aspyridone B catabolism" EXACT [GOC:TermGenie] synonym: "aspyridone B degradation" EXACT [GOC:TermGenie] is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process is_a: GO:1901519 ! aspyridone B metabolic process created_by: di creation_date: 2012-10-18T18:31:44Z [Term] id: GO:1901521 name: aspyridone B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspyridone B." [GOC:di, GOC:TermGenie] synonym: "aspyridone B anabolism" EXACT [GOC:TermGenie] synonym: "aspyridone B biosynthesis" EXACT [GOC:TermGenie] synonym: "aspyridone B formation" EXACT [GOC:TermGenie] synonym: "aspyridone B synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:1901519 ! aspyridone B metabolic process created_by: di creation_date: 2012-10-18T18:31:52Z [Term] id: GO:1901522 name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777] synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0070887 ! cellular response to chemical stimulus created_by: al creation_date: 2012-10-19T08:25:05Z [Term] id: GO:1901523 name: icosanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of icosanoid." [GOC:pr, GOC:TermGenie] synonym: "icosanoid breakdown" EXACT [GOC:TermGenie] synonym: "icosanoid catabolism" EXACT [GOC:TermGenie] synonym: "icosanoid degradation" EXACT [GOC:TermGenie] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901569 ! fatty acid derivative catabolic process created_by: pr creation_date: 2012-10-22T10:50:09Z [Term] id: GO:1901524 name: regulation of mitophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie] synonym: "regulation of macromitophagy" EXACT [] is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:1903146 ! regulation of autophagy of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000423 ! mitophagy relationship: regulates GO:0000423 ! mitophagy created_by: krc creation_date: 2012-10-22T16:56:45Z [Term] id: GO:1901525 name: negative regulation of mitophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy." [GOC:TermGenie] synonym: "down regulation of macromitophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of macromitophagy" EXACT [GOC:TermGenie] synonym: "downregulation of macromitophagy" EXACT [GOC:TermGenie] synonym: "inhibition of macromitophagy" NARROW [GOC:TermGenie] synonym: "negative regulation of macromitophagy" EXACT [] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:1901524 ! regulation of mitophagy is_a: GO:1903147 ! negative regulation of autophagy of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000423 ! mitophagy relationship: negatively_regulates GO:0000423 ! mitophagy created_by: krc creation_date: 2012-10-22T16:56:49Z [Term] id: GO:1901526 name: positive regulation of mitophagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitophagy." [GOC:TermGenie] synonym: "activation of macromitophagy" NARROW [GOC:TermGenie] synonym: "positive regulation of macromitophagy" EXACT [] synonym: "up regulation of macromitophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of macromitophagy" EXACT [GOC:TermGenie] synonym: "upregulation of macromitophagy" EXACT [GOC:TermGenie] is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:1901524 ! regulation of mitophagy is_a: GO:1903599 ! positive regulation of autophagy of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000423 ! mitophagy relationship: positively_regulates GO:0000423 ! mitophagy created_by: krc creation_date: 2012-10-22T16:56:57Z [Term] id: GO:1901527 name: abscisic acid-activated signaling pathway involved in stomatal movement namespace: biological_process def: "Any abscisic acid mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie, PMID:22730405] synonym: "abscisic acid mediated signaling pathway involved in stomatal movement" RELATED [] synonym: "abscisic acid mediated signalling involved in stomatal movement" EXACT [GOC:TermGenie] is_a: GO:0009738 ! abscisic acid-activated signaling pathway intersection_of: GO:0009738 ! abscisic acid-activated signaling pathway intersection_of: part_of GO:0010118 ! stomatal movement relationship: part_of GO:0010118 ! stomatal movement created_by: tb creation_date: 2012-10-23T23:09:34Z [Term] id: GO:1901528 name: hydrogen peroxide mediated signaling pathway involved in stomatal movement namespace: biological_process def: "Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie] synonym: "H2O2 mediated signaling pathway involved in stomatal movement" EXACT [GOC:TermGenie] synonym: "hydrogen peroxide mediated signalling pathway involved in stomatal movement" EXACT [GOC:TermGenie] is_a: GO:0071588 ! hydrogen peroxide mediated signaling pathway intersection_of: GO:0071588 ! hydrogen peroxide mediated signaling pathway intersection_of: part_of GO:0010118 ! stomatal movement relationship: part_of GO:0010118 ! stomatal movement created_by: tb creation_date: 2012-10-23T23:15:25Z [Term] id: GO:1901529 name: positive regulation of anion channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion channel activity." [GOC:TermGenie] synonym: "activation of anion channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of anion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of anion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of anion channel activity" EXACT [GOC:TermGenie] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1903961 ! positive regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005253 ! anion channel activity relationship: positively_regulates GO:0005253 ! anion channel activity created_by: tb creation_date: 2012-10-23T23:38:50Z [Term] id: GO:1901530 name: response to hypochlorite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance created_by: pr creation_date: 2012-10-24T07:12:21Z [Term] id: GO:1901531 name: hypochlorite binding namespace: molecular_function def: "Interacting selectively and non-covalently with hypochlorite." [GOC:pr, GOC:TermGenie, PMID:22223481] is_a: GO:0043168 ! anion binding created_by: pr creation_date: 2012-10-24T07:15:22Z [Term] id: GO:1901532 name: regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002244 ! hematopoietic progenitor cell differentiation relationship: regulates GO:0002244 ! hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:01Z [Term] id: GO:1901533 name: negative regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation relationship: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:06Z [Term] id: GO:1901534 name: positive regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT [] synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation relationship: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation created_by: vk creation_date: 2012-10-24T11:23:14Z [Term] id: GO:1901535 name: regulation of DNA demethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080111 ! DNA demethylation relationship: regulates GO:0080111 ! DNA demethylation created_by: jl creation_date: 2012-10-24T13:52:50Z [Term] id: GO:1901536 name: negative regulation of DNA demethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] synonym: "down regulation of DNA demethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA demethylation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA demethylation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA demethylation" NARROW [GOC:TermGenie] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1901535 ! regulation of DNA demethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0080111 ! DNA demethylation relationship: negatively_regulates GO:0080111 ! DNA demethylation created_by: jl creation_date: 2012-10-24T13:52:54Z [Term] id: GO:1901537 name: positive regulation of DNA demethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] synonym: "activation of DNA demethylation" NARROW [GOC:TermGenie] synonym: "up regulation of DNA demethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA demethylation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA demethylation" EXACT [GOC:TermGenie] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1901535 ! regulation of DNA demethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0080111 ! DNA demethylation relationship: positively_regulates GO:0080111 ! DNA demethylation created_by: jl creation_date: 2012-10-24T13:52:59Z [Term] id: GO:1901538 name: changes to DNA methylation involved in embryo development namespace: biological_process def: "The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression." [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryo development" EXACT [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryogenesis" EXACT [GOC:TermGenie] synonym: "changes in DNA methylation involved in embryonal development" RELATED [GOC:TermGenie] synonym: "DNA methylation or demethylation involved in embryogenesis" EXACT [GOC:TermGenie] synonym: "DNA methylation or demethylation involved in embryonal development" EXACT [GOC:TermGenie] is_a: GO:0044728 ! DNA methylation or demethylation intersection_of: GO:0044728 ! DNA methylation or demethylation intersection_of: part_of GO:0009790 ! embryo development relationship: part_of GO:0009790 ! embryo development created_by: jl creation_date: 2012-10-25T14:53:43Z [Term] id: GO:1901539 name: ent-pimara-8(14),15-diene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene metabolism" EXACT [GOC:TermGenie] is_a: GO:0042214 ! terpene metabolic process created_by: di creation_date: 2012-10-25T15:38:13Z [Term] id: GO:1901540 name: ent-pimara-8(14),15-diene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene breakdown" EXACT [GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene catabolism" EXACT [GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene degradation" EXACT [GOC:TermGenie] is_a: GO:0046247 ! terpene catabolic process is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process created_by: di creation_date: 2012-10-25T15:38:17Z [Term] id: GO:1901541 name: ent-pimara-8(14),15-diene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process created_by: di creation_date: 2012-10-25T15:38:21Z [Term] id: GO:1901542 name: regulation of ent-pimara-8(14),15-diene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process relationship: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process created_by: di creation_date: 2012-10-26T11:37:54Z [Term] id: GO:1901543 name: negative regulation of ent-pimara-8(14),15-diene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "down regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "down regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "downregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie] synonym: "inhibition of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process relationship: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process created_by: di creation_date: 2012-10-26T11:37:58Z [Term] id: GO:1901544 name: positive regulation of ent-pimara-8(14),15-diene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "activation of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie] synonym: "activation of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie] synonym: "activation of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "up regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] synonym: "upregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process relationship: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process created_by: di creation_date: 2012-10-26T11:38:07Z [Term] id: GO:1901545 name: response to raffinose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:TermGenie] is_a: GO:0009743 ! response to carbohydrate created_by: al creation_date: 2012-10-26T14:32:23Z [Term] id: GO:1901546 name: regulation of synaptic vesicle lumen acidification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] subset: goslim_synapse synonym: "regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "regulation of synaptic vesicle lumen proton loading" EXACT syngo_official_label [] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0050793 ! regulation of developmental process is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0065008 ! regulation of biological quality is_a: GO:0098693 ! regulation of synaptic vesicle cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097401 ! synaptic vesicle lumen acidification relationship: regulates GO:0097401 ! synaptic vesicle lumen acidification created_by: dsf creation_date: 2012-10-26T16:09:24Z [Term] id: GO:1901547 name: negative regulation of synaptic vesicle lumen acidification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] synonym: "down regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "inhibition of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie] synonym: "negative regulation of proton loading" EXACT syngo_official_label [] synonym: "negative regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification relationship: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification created_by: dsf creation_date: 2012-10-26T16:09:28Z [Term] id: GO:1901548 name: positive regulation of synaptic vesicle lumen acidification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] synonym: "activation of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie] synonym: "positive regulation of proton loading" EXACT syngo_official_label [] synonym: "positive regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification relationship: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification created_by: dsf creation_date: 2012-10-26T16:09:32Z [Term] id: GO:1901550 name: regulation of endothelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] is_a: GO:0045601 ! regulation of endothelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001885 ! endothelial cell development relationship: regulates GO:0001885 ! endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:50Z [Term] id: GO:1901551 name: negative regulation of endothelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001885 ! endothelial cell development relationship: negatively_regulates GO:0001885 ! endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:54Z [Term] id: GO:1901552 name: positive regulation of endothelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0045603 ! positive regulation of endothelial cell differentiation is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001885 ! endothelial cell development relationship: positively_regulates GO:0001885 ! endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:58Z [Term] id: GO:1901553 name: malonic acid transmembrane transport namespace: biological_process def: "The directed movement of malonic acid across a membrane." [GOC:al, GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "malonic acid membrane transport" EXACT [] is_a: GO:1900752 ! malonic acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: pr creation_date: 2012-10-30T15:23:54Z [Term] id: GO:1901554 name: response to paracetamol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie] synonym: "response to acetaminophen" EXACT [] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:43:23Z [Term] id: GO:1901555 name: response to paclitaxel namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie] is_a: GO:0033993 ! response to lipid is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2012-11-02T09:46:08Z [Term] id: GO:1901556 name: response to candesartan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:13Z [Term] id: GO:1901557 name: response to fenofibrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0045472 ! response to ether is_a: GO:1901654 ! response to ketone created_by: hp creation_date: 2012-11-02T09:46:20Z [Term] id: GO:1901558 name: response to metformin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0042493 ! response to drug created_by: hp creation_date: 2012-11-02T09:46:24Z [Term] id: GO:1901559 name: response to ribavirin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0061479 ! response to reverse transcriptase inhibitor is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:28Z [Term] id: GO:1901560 name: response to purvalanol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:TermGenie] is_a: GO:0014074 ! response to purine-containing compound created_by: mah creation_date: 2012-11-02T15:32:28Z [Term] id: GO:1901561 name: response to benomyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0060992 ! response to fungicide is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-02T15:32:33Z [Term] id: GO:1901562 name: response to paraquat namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie] is_a: GO:0009635 ! response to herbicide is_a: GO:0010033 ! response to organic substance created_by: mah creation_date: 2012-11-02T15:32:41Z [Term] id: GO:1901563 name: response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] synonym: "response to CPT" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2012-11-02T15:32:45Z [Term] id: GO:1901564 name: organonitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-04T15:17:52Z [Term] id: GO:1901565 name: organonitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie] synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: pr creation_date: 2012-11-04T15:17:56Z [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-11-04T15:18:00Z [Term] id: GO:1901567 name: fatty acid derivative binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acid derivative." [GOC:pr, GOC:TermGenie] is_a: GO:0005488 ! binding created_by: pr creation_date: 2012-11-04T17:13:28Z [Term] id: GO:1901568 name: fatty acid derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie] synonym: "fatty acid derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-04T17:13:36Z [Term] id: GO:1901569 name: fatty acid derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative." [GOC:pr, GOC:TermGenie] synonym: "fatty acid derivative breakdown" EXACT [GOC:TermGenie] synonym: "fatty acid derivative catabolism" EXACT [GOC:TermGenie] synonym: "fatty acid derivative degradation" EXACT [GOC:TermGenie] is_a: GO:1901568 ! fatty acid derivative metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: pr creation_date: 2012-11-04T17:13:40Z [Term] id: GO:1901570 name: fatty acid derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acid derivative." [GOC:pr, GOC:TermGenie] synonym: "fatty acid derivative anabolism" EXACT [GOC:TermGenie] synonym: "fatty acid derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "fatty acid derivative formation" EXACT [GOC:TermGenie] synonym: "fatty acid derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:1901568 ! fatty acid derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-11-04T17:13:44Z [Term] id: GO:1901571 name: fatty acid derivative transport namespace: biological_process def: "The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:0071702 ! organic substance transport created_by: pr creation_date: 2012-11-04T17:13:49Z [Term] id: GO:1901572 name: obsolete chemical substance metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving chemical substance." [GOC:pr, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "chemical substance metabolic process" EXACT [] synonym: "chemical substance metabolism" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2012-11-04T18:10:32Z [Term] id: GO:1901573 name: obsolete chemical substance catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chemical substance." [GOC:pr, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "chemical substance breakdown" EXACT [GOC:TermGenie] synonym: "chemical substance catabolic process" EXACT [] synonym: "chemical substance catabolism" EXACT [GOC:TermGenie] synonym: "chemical substance degradation" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2012-11-04T18:10:36Z [Term] id: GO:1901574 name: obsolete chemical substance biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of chemical substance." [GOC:pr, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "chemical substance anabolism" EXACT [GOC:TermGenie] synonym: "chemical substance biosynthesis" EXACT [GOC:TermGenie] synonym: "chemical substance biosynthetic process" EXACT [] synonym: "chemical substance formation" EXACT [GOC:TermGenie] synonym: "chemical substance synthesis" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2012-11-04T18:10:40Z [Term] id: GO:1901575 name: organic substance catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie] synonym: "organic molecular entity catabolic process" EXACT [] synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie] synonym: "organic substance breakdown" EXACT [] synonym: "organic substance catabolism" EXACT [] synonym: "organic substance degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-05T11:04:36Z [Term] id: GO:1901576 name: organic substance biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthetic process" EXACT [] synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] synonym: "organic substance anabolism" EXACT [] synonym: "organic substance biosynthesis" EXACT [] synonym: "organic substance formation" EXACT [] synonym: "organic substance synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-05T11:04:40Z [Term] id: GO:1901577 name: regulation of alkane biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] synonym: "regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "regulation of alkane synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043447 ! alkane biosynthetic process relationship: regulates GO:0043447 ! alkane biosynthetic process created_by: dhl creation_date: 2012-11-05T21:54:06Z [Term] id: GO:1901578 name: negative regulation of alkane biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] synonym: "down regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "down regulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "down-regulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of alkane formation" EXACT [GOC:TermGenie] synonym: "downregulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of alkane anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of alkane biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of alkane formation" EXACT [GOC:TermGenie] synonym: "inhibition of alkane synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "negative regulation of alkane synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043447 ! alkane biosynthetic process relationship: negatively_regulates GO:0043447 ! alkane biosynthetic process created_by: dhl creation_date: 2012-11-05T21:54:11Z [Term] id: GO:1901579 name: positive regulation of alkane biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] synonym: "activation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "activation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of alkane biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of alkane formation" EXACT [GOC:TermGenie] synonym: "activation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "positive regulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "up regulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of alkane formation" EXACT [GOC:TermGenie] synonym: "up-regulation of alkane synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alkane anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of alkane biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alkane biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of alkane formation" EXACT [GOC:TermGenie] synonym: "upregulation of alkane synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043447 ! alkane biosynthetic process relationship: positively_regulates GO:0043447 ! alkane biosynthetic process created_by: dhl creation_date: 2012-11-05T21:54:19Z [Term] id: GO:1901580 name: regulation of telomeric RNA transcription from RNA pol II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] synonym: "regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II relationship: regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II created_by: al creation_date: 2012-11-06T11:07:16Z [Term] id: GO:1901581 name: negative regulation of telomeric RNA transcription from RNA pol II promoter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] synonym: "down regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] synonym: "inhibition of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "inhibition of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II relationship: negatively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II created_by: al creation_date: 2012-11-06T11:07:21Z [Term] id: GO:1901582 name: positive regulation of telomeric RNA transcription from RNA pol II promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] synonym: "activation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "activation of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II relationship: positively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II created_by: al creation_date: 2012-11-06T11:07:25Z [Term] id: GO:1901583 name: tetrapeptide transmembrane transport namespace: biological_process def: "The directed movement of tetrapeptide across a membrane." [GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "tetrapeptide membrane transport" EXACT [] is_a: GO:0035672 ! oligopeptide transmembrane transport created_by: jl creation_date: 2012-11-06T15:40:02Z [Term] id: GO:1901584 name: tetrapeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tetrapeptide from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity relationship: part_of GO:1901583 ! tetrapeptide transmembrane transport created_by: jl creation_date: 2012-11-06T15:40:10Z [Term] id: GO:1901585 name: regulation of acid-sensing ion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] synonym: "regulation of ASIC activity" EXACT [GOC:TermGenie] is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044736 ! acid-sensing ion channel activity relationship: regulates GO:0044736 ! acid-sensing ion channel activity created_by: jl creation_date: 2012-11-07T13:37:24Z [Term] id: GO:1901586 name: negative regulation of acid-sensing ion channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] synonym: "down regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "downregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "inhibition of acid-sensing ion channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of ASIC activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ASIC activity" EXACT [GOC:TermGenie] is_a: GO:1901585 ! regulation of acid-sensing ion channel activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044736 ! acid-sensing ion channel activity relationship: negatively_regulates GO:0044736 ! acid-sensing ion channel activity created_by: jl creation_date: 2012-11-07T13:37:32Z [Term] id: GO:1901587 name: positive regulation of acid-sensing ion channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] synonym: "activation of acid-sensing ion channel activity" NARROW [GOC:TermGenie] synonym: "activation of ASIC activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "up regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ASIC activity" EXACT [GOC:TermGenie] synonym: "upregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of ASIC activity" EXACT [GOC:TermGenie] is_a: GO:1901585 ! regulation of acid-sensing ion channel activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044736 ! acid-sensing ion channel activity relationship: positively_regulates GO:0044736 ! acid-sensing ion channel activity created_by: jl creation_date: 2012-11-07T13:37:37Z [Term] id: GO:1901588 name: dendritic microtubule namespace: cellular_component def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650] synonym: "microtubule of dendrite" EXACT [GOC:TermGenie] synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao110773650 is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0030425 ! dendrite relationship: part_of GO:0030425 ! dendrite created_by: pr creation_date: 2012-11-07T14:37:30Z [Term] id: GO:1901589 name: axon microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678] synonym: "axon microtubule fascicle" EXACT [] synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao707332678 is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: part_of GO:0030424 ! axon relationship: part_of GO:0030424 ! axon created_by: pr creation_date: 2012-11-07T15:37:12Z [Term] id: GO:1901591 name: regulation of double-strand break repair via break-induced replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie] is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000727 ! double-strand break repair via break-induced replication relationship: regulates GO:0000727 ! double-strand break repair via break-induced replication created_by: al creation_date: 2012-11-07T16:37:34Z [Term] id: GO:1901592 name: negative regulation of double-strand break repair via break-induced replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie] synonym: "down regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] synonym: "down-regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] synonym: "downregulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] synonym: "inhibition of double-strand break repair via break-induced replication" NARROW [GOC:TermGenie] is_a: GO:1901591 ! regulation of double-strand break repair via break-induced replication is_a: GO:2000042 ! negative regulation of double-strand break repair via homologous recombination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication relationship: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication created_by: al creation_date: 2012-11-07T16:37:39Z [Term] id: GO:1901593 name: response to GW 7647 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:16:48Z [Term] id: GO:1901594 name: response to capsazepine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:16:53Z [Term] id: GO:1901595 name: response to hesperadin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0014075 ! response to amine is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:16:57Z [Term] id: GO:1901596 name: response to reversine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:17:01Z [Term] id: GO:1901597 name: response to carbendazim namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0060992 ! response to fungicide is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:17:06Z [Term] id: GO:1901598 name: (-)-pinoresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-pinoresinol." [GOC:TermGenie] synonym: "(-)-pinoresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: tb creation_date: 2012-11-08T01:15:57Z [Term] id: GO:1901599 name: (-)-pinoresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-pinoresinol." [GOC:TermGenie] synonym: "(-)-pinoresinol anabolism" EXACT [GOC:TermGenie] synonym: "(-)-pinoresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-pinoresinol formation" EXACT [GOC:TermGenie] synonym: "(-)-pinoresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901598 ! (-)-pinoresinol metabolic process created_by: tb creation_date: 2012-11-08T01:16:05Z [Term] id: GO:1901600 name: strigolactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie] synonym: "strigolactone metabolism" EXACT [GOC:TermGenie] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: tb creation_date: 2012-11-08T01:20:09Z [Term] id: GO:1901601 name: strigolactone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of strigolactone." [GOC:TermGenie] synonym: "strigolactone anabolism" EXACT [GOC:TermGenie] synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie] synonym: "strigolactone formation" EXACT [GOC:TermGenie] synonym: "strigolactone synthesis" EXACT [GOC:TermGenie] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process is_a: GO:1901600 ! strigolactone metabolic process created_by: tb creation_date: 2012-11-08T01:20:13Z [Term] id: GO:1901602 name: dethiobiotin binding namespace: molecular_function def: "Interacting selectively and non-covalently with dethiobiotin." [GOC:TermGenie] is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: al creation_date: 2012-11-08T14:09:14Z [Term] id: GO:1901604 name: dethiobiotin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of dethiobiotin from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity created_by: al creation_date: 2012-11-08T14:42:53Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! cellular amino acid metabolic process created_by: tb creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: tb creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: tb creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901608 name: regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0047496 ! vesicle transport along microtubule relationship: regulates GO:0047496 ! vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:44Z [Term] id: GO:1901609 name: negative regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0047496 ! vesicle transport along microtubule relationship: negatively_regulates GO:0047496 ! vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:48Z [Term] id: GO:1901610 name: positive regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0047496 ! vesicle transport along microtubule relationship: positively_regulates GO:0047496 ! vesicle transport along microtubule created_by: hjd creation_date: 2012-11-08T21:49:53Z [Term] id: GO:1901611 name: phosphatidylglycerol binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylglycerol." [GOC:kmv, GOC:TermGenie] is_a: GO:0005543 ! phospholipid binding created_by: kmv creation_date: 2012-11-12T21:18:24Z [Term] id: GO:1901612 name: cardiolipin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cardiolipin." [GOC:kmv, GOC:TermGenie] is_a: GO:1901611 ! phosphatidylglycerol binding created_by: kmv creation_date: 2012-11-12T21:19:50Z [Term] id: GO:1901613 name: negative regulation of terminal button organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] synonym: "down regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "down regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "down regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "down-regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "downregulation of bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "downregulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "downregulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "inhibition of bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of terminal bouton organization" NARROW [GOC:TermGenie] synonym: "inhibition of terminal button organisation" NARROW [GOC:TermGenie] synonym: "inhibition of terminal button organization" NARROW [GOC:TermGenie] synonym: "negative regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal button organisation" EXACT [GOC:TermGenie] is_a: GO:1905809 ! negative regulation of synapse organization is_a: GO:2000331 ! regulation of terminal button organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072553 ! terminal button organization relationship: negatively_regulates GO:0072553 ! terminal button organization created_by: lb creation_date: 2012-11-13T10:40:51Z [Term] id: GO:1901614 name: positive regulation of terminal button organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] synonym: "activation of bouton organization" NARROW [GOC:TermGenie] synonym: "activation of presynaptic bouton organization" NARROW [GOC:TermGenie] synonym: "activation of synaptic bouton organization" NARROW [GOC:TermGenie] synonym: "activation of terminal bouton organization" NARROW [GOC:TermGenie] synonym: "activation of terminal button organisation" NARROW [GOC:TermGenie] synonym: "activation of terminal button organization" NARROW [GOC:TermGenie] synonym: "positive regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "up regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "up-regulation of bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal button organization" EXACT [GOC:TermGenie] synonym: "upregulation of bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of terminal bouton organization" EXACT [GOC:TermGenie] synonym: "upregulation of terminal button organisation" EXACT [GOC:TermGenie] synonym: "upregulation of terminal button organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000331 ! regulation of terminal button organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072553 ! terminal button organization relationship: positively_regulates GO:0072553 ! terminal button organization created_by: lb creation_date: 2012-11-13T10:40:58Z [Term] id: GO:1901615 name: organic hydroxy compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: pr creation_date: 2012-11-13T12:54:27Z [Term] id: GO:1901616 name: organic hydroxy compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901575 ! organic substance catabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: pr creation_date: 2012-11-13T12:54:31Z [Term] id: GO:1901617 name: organic hydroxy compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: pr creation_date: 2012-11-13T12:54:36Z [Term] id: GO:1901618 name: organic hydroxy compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity created_by: pr creation_date: 2012-11-13T12:59:01Z [Term] id: GO:1901619 name: obsolete tRNA methylation in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule as a result of deprivation of nitrogen." [GOC:TermGenie, PMID:23074192] is_obsolete: true created_by: al creation_date: 2012-11-13T14:36:00Z [Term] id: GO:1901620 name: regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] synonym: "regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] is_a: GO:0008589 ! regulation of smoothened signaling pathway is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning relationship: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning created_by: krc creation_date: 2012-11-13T20:11:57Z [Term] id: GO:1901621 name: negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] synonym: "down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] is_a: GO:0045879 ! negative regulation of smoothened signaling pathway is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning relationship: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning created_by: krc creation_date: 2012-11-13T20:12:01Z [Term] id: GO:1901622 name: positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] synonym: "activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "activation of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] synonym: "positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] synonym: "upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0045880 ! positive regulation of smoothened signaling pathway is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning relationship: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning created_by: krc creation_date: 2012-11-13T20:12:06Z [Term] id: GO:1901623 name: regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048247 ! lymphocyte chemotaxis relationship: regulates GO:0048247 ! lymphocyte chemotaxis created_by: tb creation_date: 2012-11-13T23:03:23Z [Term] id: GO:1901624 name: negative regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000402 ! negative regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048247 ! lymphocyte chemotaxis relationship: negatively_regulates GO:0048247 ! lymphocyte chemotaxis created_by: tb creation_date: 2012-11-13T23:03:28Z [Term] id: GO:1901625 name: cellular response to ergosterol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus." [GOC:TermGenie] is_a: GO:0036315 ! cellular response to sterol is_a: GO:0097306 ! cellular response to alcohol created_by: dph creation_date: 2012-11-14T13:53:51Z [Term] id: GO:1901626 name: regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "regulation of post-synaptic membrane organization" EXACT [] synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001941 ! postsynaptic membrane organization relationship: regulates GO:0001941 ! postsynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:15Z [Term] id: GO:1901627 name: negative regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "negative regulation of post-synaptic membrane organization" EXACT [] synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:1901626 ! regulation of postsynaptic membrane organization is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001941 ! postsynaptic membrane organization relationship: negatively_regulates GO:0001941 ! postsynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:20Z [Term] id: GO:1901628 name: positive regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "positive regulation of post-synaptic membrane organization" EXACT [] synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901626 ! regulation of postsynaptic membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001941 ! postsynaptic membrane organization relationship: positively_regulates GO:0001941 ! postsynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:24Z [Term] id: GO:1901629 name: regulation of presynaptic membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "regulation of pre-synaptic membrane organization" EXACT [] synonym: "regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097090 ! presynaptic membrane organization relationship: regulates GO:0097090 ! presynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:32Z [Term] id: GO:1901630 name: negative regulation of presynaptic membrane organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "down regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "inhibition of presynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "negative regulation of pre-synaptic membrane organization" EXACT [] synonym: "negative regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:1901629 ! regulation of presynaptic membrane organization is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097090 ! presynaptic membrane organization relationship: negatively_regulates GO:0097090 ! presynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:36Z [Term] id: GO:1901631 name: positive regulation of presynaptic membrane organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "activation of presynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "activation of presynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "positive regulation of pre-synaptic membrane organization" EXACT [] synonym: "positive regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic membrane organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901629 ! regulation of presynaptic membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097090 ! presynaptic membrane organization relationship: positively_regulates GO:0097090 ! presynaptic membrane organization created_by: ans creation_date: 2012-11-15T11:40:40Z [Term] id: GO:1901632 name: regulation of synaptic vesicle membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048499 ! synaptic vesicle membrane organization relationship: regulates GO:0048499 ! synaptic vesicle membrane organization created_by: ans creation_date: 2012-11-15T11:40:48Z [Term] id: GO:1901633 name: negative regulation of synaptic vesicle membrane organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "down regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle membrane organization" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle membrane organization and biogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization relationship: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization created_by: ans creation_date: 2012-11-15T11:40:55Z [Term] id: GO:1901634 name: positive regulation of synaptic vesicle membrane organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PubMed:22426000] synonym: "activation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle membrane organization" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of SLMV biogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048499 ! synaptic vesicle membrane organization relationship: positively_regulates GO:0048499 ! synaptic vesicle membrane organization created_by: ans creation_date: 2012-11-15T11:40:59Z [Term] id: GO:1901635 name: obsolete regulation of maintenance of presynaptic active zone structure namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of maintenance of presynaptic active zone structure" EXACT [] is_obsolete: true created_by: ans creation_date: 2012-11-15T14:17:03Z [Term] id: GO:1901636 name: obsolete negative regulation of maintenance of presynaptic active zone structure namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] synonym: "inhibition of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie] synonym: "negative regulation of maintenance of presynaptic active zone structure" EXACT [] is_obsolete: true created_by: ans creation_date: 2012-11-15T14:17:07Z [Term] id: GO:1901637 name: obsolete positive regulation of maintenance of presynaptic active zone structure namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PubMed:22426000] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie] synonym: "positive regulation of maintenance of presynaptic active zone structure" EXACT [] synonym: "up regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] is_obsolete: true created_by: ans creation_date: 2012-11-15T14:17:16Z [Term] id: GO:1901638 name: obsolete copper ion import into ascospore-type prospore namespace: biological_process def: "OBSOLETE. Any copper ion import that takes place in ascospore-type prospore." [GOC:TermGenie] comment: https://sourceforge.net/tracker/index.php?func=detail&aid=3510080&group_id=36855&atid=440764 synonym: "copper ion import into ascospore-type prospore" EXACT [] synonym: "copper ion uptake in ascospore-type prospore" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-11-15T15:44:04Z [Term] id: GO:1901639 name: XDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of XDP." [GOC:TermGenie] synonym: "XDP breakdown" EXACT [GOC:TermGenie] synonym: "XDP catabolism" EXACT [GOC:TermGenie] synonym: "XDP degradation" EXACT [GOC:TermGenie] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process created_by: tb creation_date: 2012-11-15T22:56:26Z [Term] id: GO:1901640 name: XTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with XTP." [GOC:TermGenie] is_a: GO:0032555 ! purine ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding created_by: tb creation_date: 2012-11-15T22:56:35Z [Term] id: GO:1901641 name: ITP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ITP." [GOC:TermGenie] is_a: GO:0032555 ! purine ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding created_by: tb creation_date: 2012-11-15T22:56:39Z [Term] id: GO:1901642 name: nucleoside transmembrane transport namespace: biological_process def: "The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nucleoside membrane transport" EXACT [] is_a: GO:0015858 ! nucleoside transport is_a: GO:0055085 ! transmembrane transport created_by: pr creation_date: 2012-11-16T13:32:01Z [Term] id: GO:1901643 name: obsolete regulation of tRNA methylation in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-11-16T14:44:08Z [Term] id: GO:1901644 name: obsolete positive regulation of tRNA methylation in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie] synonym: "activation of tRNA methylation in response to nitrogen starvation" NARROW [GOC:TermGenie] synonym: "up regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2012-11-16T14:44:12Z [Term] id: GO:1901645 name: regulation of synoviocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002941 ! synoviocyte proliferation relationship: regulates GO:0002941 ! synoviocyte proliferation created_by: hjd creation_date: 2012-11-16T20:16:23Z [Term] id: GO:1901646 name: negative regulation of synoviocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] synonym: "down regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of synoviocyte proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1901645 ! regulation of synoviocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002941 ! synoviocyte proliferation relationship: negatively_regulates GO:0002941 ! synoviocyte proliferation created_by: hjd creation_date: 2012-11-16T20:16:27Z [Term] id: GO:1901647 name: positive regulation of synoviocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] synonym: "activation of synoviocyte proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1901645 ! regulation of synoviocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002941 ! synoviocyte proliferation relationship: positively_regulates GO:0002941 ! synoviocyte proliferation created_by: hjd creation_date: 2012-11-16T20:16:32Z [Term] id: GO:1901648 name: regulation of actomyosin contractile ring localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] synonym: "regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization is_a: GO:0032954 ! regulation of cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032187 ! actomyosin contractile ring localization relationship: regulates GO:0032187 ! actomyosin contractile ring localization created_by: vw creation_date: 2012-11-19T13:42:45Z [Term] id: GO:1901649 name: negative regulation of actomyosin contractile ring localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] synonym: "down regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "down regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "down regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "down-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "downregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "inhibition of actomyosin contractile ring localization" NARROW [GOC:TermGenie] synonym: "inhibition of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "inhibition of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "negative regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "negative regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:1901648 ! regulation of actomyosin contractile ring localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032187 ! actomyosin contractile ring localization relationship: negatively_regulates GO:0032187 ! actomyosin contractile ring localization created_by: vw creation_date: 2012-11-19T13:42:49Z [Term] id: GO:1901650 name: positive regulation of actomyosin contractile ring localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] synonym: "activation of actomyosin contractile ring localization" NARROW [GOC:TermGenie] synonym: "activation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "activation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "positive regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "positive regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "up regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "up regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "up regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "up-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "upregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:1901648 ! regulation of actomyosin contractile ring localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032187 ! actomyosin contractile ring localization relationship: positively_regulates GO:0032187 ! actomyosin contractile ring localization created_by: vw creation_date: 2012-11-19T13:42:54Z [Term] id: GO:1901651 name: regulation of mitotic chromosome decondensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome decondensation." [GOC:TermGenie] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007083 ! mitotic chromosome decondensation relationship: regulates GO:0007083 ! mitotic chromosome decondensation created_by: dph creation_date: 2012-11-19T14:13:58Z [Term] id: GO:1901652 name: response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T09:45:15Z [Term] id: GO:1901653 name: cellular response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901652 ! response to peptide is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T09:45:19Z [Term] id: GO:1901654 name: response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T10:55:47Z [Term] id: GO:1901655 name: cellular response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:1901654 ! response to ketone is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: pr creation_date: 2012-11-20T10:55:51Z [Term] id: GO:1901656 name: glycoside transport namespace: biological_process def: "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:1901264 ! carbohydrate derivative transport created_by: pr creation_date: 2012-11-20T11:59:16Z [Term] id: GO:1901657 name: glycosyl compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: pr creation_date: 2012-11-20T14:24:07Z [Term] id: GO:1901658 name: glycosyl compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound breakdown" EXACT [GOC:TermGenie] synonym: "glycosyl compound catabolism" EXACT [GOC:TermGenie] synonym: "glycosyl compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1901657 ! glycosyl compound metabolic process created_by: pr creation_date: 2012-11-20T14:24:11Z [Term] id: GO:1901659 name: glycosyl compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie] synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie] synonym: "glycosyl compound formation" EXACT [GOC:TermGenie] synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901657 ! glycosyl compound metabolic process created_by: pr creation_date: 2012-11-20T14:24:19Z [Term] id: GO:1901660 name: calcium ion export namespace: biological_process def: "The directed movement of calcium ion out of a cell or organelle." [GOC:TermGenie] is_a: GO:0006816 ! calcium ion transport created_by: jl creation_date: 2012-11-20T14:33:07Z [Term] id: GO:1901661 name: quinone metabolic process namespace: biological_process alt_id: GO:0042375 def: "The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie] synonym: "quinone cofactor metabolic process" RELATED [] synonym: "quinone cofactor metabolism" RELATED [] synonym: "quinone metabolism" EXACT [GOC:TermGenie] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0051186 ! cofactor metabolic process created_by: pr creation_date: 2012-11-20T14:44:39Z [Term] id: GO:1901662 name: quinone catabolic process namespace: biological_process alt_id: GO:0042378 def: "The chemical reactions and pathways resulting in the breakdown of quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie] synonym: "quinone breakdown" EXACT [GOC:TermGenie] synonym: "quinone catabolism" EXACT [GOC:TermGenie] synonym: "quinone cofactor breakdown" RELATED [] synonym: "quinone cofactor catabolic process" RELATED [] synonym: "quinone cofactor catabolism" RELATED [] synonym: "quinone cofactor degradation" RELATED [] synonym: "quinone degradation" EXACT [GOC:TermGenie] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1901661 ! quinone metabolic process created_by: pr creation_date: 2012-11-20T14:44:44Z [Term] id: GO:1901663 name: quinone biosynthetic process namespace: biological_process alt_id: GO:0045426 def: "The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie] synonym: "quinone anabolism" EXACT [GOC:TermGenie] synonym: "quinone biosynthesis" EXACT [GOC:TermGenie] synonym: "quinone cofactor anabolism" RELATED [] synonym: "quinone cofactor biosynthesis" RELATED [] synonym: "quinone cofactor biosynthetic process" RELATED [] synonym: "quinone cofactor formation" RELATED [] synonym: "quinone cofactor synthesis" RELATED [] synonym: "quinone formation" EXACT [GOC:TermGenie] synonym: "quinone synthesis" EXACT [GOC:TermGenie] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901661 ! quinone metabolic process created_by: pr creation_date: 2012-11-20T14:44:48Z [Term] id: GO:1901664 name: regulation of NAD+ ADP-ribosyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] synonym: "regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity relationship: regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity created_by: vk creation_date: 2012-11-20T18:50:07Z [Term] id: GO:1901665 name: negative regulation of NAD+ ADP-ribosyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "down regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "downregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "inhibition of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "inhibition of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "inhibition of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "inhibition of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity relationship: negatively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity created_by: vk creation_date: 2012-11-20T18:50:15Z [Term] id: GO:1901666 name: positive regulation of NAD+ ADP-ribosyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] synonym: "activation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "activation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "activation of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "activation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "activation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "activation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "up regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] synonym: "upregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity relationship: positively_regulates GO:0003950 ! NAD+ ADP-ribosyltransferase activity created_by: vk creation_date: 2012-11-20T18:50:20Z [Term] id: GO:1901667 name: negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration." [GOC:dph, GOC:TermGenie, PMID:21272575] synonym: "down regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell activation involved in skeletal muscle regeneration" NARROW [GOC:TermGenie] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0043417 ! negative regulation of skeletal muscle tissue regeneration is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration relationship: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration created_by: dph creation_date: 2012-11-21T16:21:11Z [Term] id: GO:1901668 name: regulation of superoxide dismutase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] synonym: "regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of cuprein" RELATED [GOC:TermGenie] synonym: "regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "regulation of SOD" RELATED [GOC:TermGenie] synonym: "regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "regulation of SODF" RELATED [GOC:TermGenie] synonym: "regulation of SODS" RELATED [GOC:TermGenie] synonym: "regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity is_a: GO:2000121 ! regulation of removal of superoxide radicals intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004784 ! superoxide dismutase activity relationship: regulates GO:0004784 ! superoxide dismutase activity created_by: tb creation_date: 2012-11-21T20:46:42Z [Term] id: GO:1901670 name: negative regulation of superoxide dismutase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] synonym: "down regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "down regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of cuprein" RELATED [GOC:TermGenie] synonym: "down regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "down regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "down regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "down regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "down regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "down regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "down regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "down regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down regulation of SOD" RELATED [GOC:TermGenie] synonym: "down regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "down regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "down regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "down regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "down regulation of SODF" RELATED [GOC:TermGenie] synonym: "down regulation of SODS" RELATED [GOC:TermGenie] synonym: "down regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "down regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "down regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "down regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "down-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cuprein" RELATED [GOC:TermGenie] synonym: "down-regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "down-regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "down-regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "down-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "down-regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "down-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "down-regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "down-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "down-regulation of SOD" RELATED [GOC:TermGenie] synonym: "down-regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "down-regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "down-regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "down-regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "down-regulation of SODF" RELATED [GOC:TermGenie] synonym: "down-regulation of SODS" RELATED [GOC:TermGenie] synonym: "down-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "down-regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "down-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "downregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "downregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of cuprein" RELATED [GOC:TermGenie] synonym: "downregulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "downregulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "downregulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "downregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "downregulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "downregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "downregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "downregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "downregulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "downregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "downregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "downregulation of SOD" RELATED [GOC:TermGenie] synonym: "downregulation of SOD-1" RELATED [GOC:TermGenie] synonym: "downregulation of SOD-2" RELATED [GOC:TermGenie] synonym: "downregulation of SOD-3" RELATED [GOC:TermGenie] synonym: "downregulation of SOD-4" RELATED [GOC:TermGenie] synonym: "downregulation of SODF" RELATED [GOC:TermGenie] synonym: "downregulation of SODS" RELATED [GOC:TermGenie] synonym: "downregulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "downregulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "downregulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "downregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "inhibition of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "inhibition of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cuprein" RELATED [GOC:TermGenie] synonym: "inhibition of cytocuprein" RELATED [GOC:TermGenie] synonym: "inhibition of erythrocuprein" RELATED [GOC:TermGenie] synonym: "inhibition of Fe-SOD" RELATED [GOC:TermGenie] synonym: "inhibition of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hemocuprein" RELATED [GOC:TermGenie] synonym: "inhibition of hepatocuprein" RELATED [GOC:TermGenie] synonym: "inhibition of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "inhibition of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "inhibition of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "inhibition of Mn-SOD" RELATED [GOC:TermGenie] synonym: "inhibition of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "inhibition of SOD" RELATED [GOC:TermGenie] synonym: "inhibition of SOD-1" RELATED [GOC:TermGenie] synonym: "inhibition of SOD-2" RELATED [GOC:TermGenie] synonym: "inhibition of SOD-3" RELATED [GOC:TermGenie] synonym: "inhibition of SOD-4" RELATED [GOC:TermGenie] synonym: "inhibition of SODF" RELATED [GOC:TermGenie] synonym: "inhibition of SODS" RELATED [GOC:TermGenie] synonym: "inhibition of superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "inhibition of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "inhibition of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "inhibition of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "inhibition of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "negative regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "negative regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cuprein" RELATED [GOC:TermGenie] synonym: "negative regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "negative regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "negative regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "negative regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "negative regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "negative regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "negative regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "negative regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "negative regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "negative regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "negative regulation of SOD" RELATED [GOC:TermGenie] synonym: "negative regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "negative regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "negative regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "negative regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "negative regulation of SODF" RELATED [GOC:TermGenie] synonym: "negative regulation of SODS" RELATED [GOC:TermGenie] synonym: "negative regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "negative regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "negative regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1901668 ! regulation of superoxide dismutase activity is_a: GO:1904832 ! negative regulation of removal of superoxide radicals intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004784 ! superoxide dismutase activity relationship: negatively_regulates GO:0004784 ! superoxide dismutase activity created_by: tb creation_date: 2012-11-21T21:36:07Z [Term] id: GO:1901671 name: positive regulation of superoxide dismutase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] synonym: "activation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "activation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of cuprein" RELATED [GOC:TermGenie] synonym: "activation of cytocuprein" RELATED [GOC:TermGenie] synonym: "activation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "activation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "activation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of hemocuprein" RELATED [GOC:TermGenie] synonym: "activation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "activation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "activation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "activation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "activation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "activation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "activation of SOD" RELATED [GOC:TermGenie] synonym: "activation of SOD-1" RELATED [GOC:TermGenie] synonym: "activation of SOD-2" RELATED [GOC:TermGenie] synonym: "activation of SOD-3" RELATED [GOC:TermGenie] synonym: "activation of SOD-4" RELATED [GOC:TermGenie] synonym: "activation of SODF" RELATED [GOC:TermGenie] synonym: "activation of SODS" RELATED [GOC:TermGenie] synonym: "activation of superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "activation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "activation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "activation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "activation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "positive regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "positive regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cuprein" RELATED [GOC:TermGenie] synonym: "positive regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "positive regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "positive regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "positive regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "positive regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "positive regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "positive regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "positive regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "positive regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "positive regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "positive regulation of SOD" RELATED [GOC:TermGenie] synonym: "positive regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "positive regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "positive regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "positive regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "positive regulation of SODF" RELATED [GOC:TermGenie] synonym: "positive regulation of SODS" RELATED [GOC:TermGenie] synonym: "positive regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "positive regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "positive regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "up regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of cuprein" RELATED [GOC:TermGenie] synonym: "up regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "up regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "up regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "up regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "up regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "up regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "up regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "up regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up regulation of SOD" RELATED [GOC:TermGenie] synonym: "up regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "up regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "up regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "up regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "up regulation of SODF" RELATED [GOC:TermGenie] synonym: "up regulation of SODS" RELATED [GOC:TermGenie] synonym: "up regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "up regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "up regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "up regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "up-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cuprein" RELATED [GOC:TermGenie] synonym: "up-regulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "up-regulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "up-regulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "up-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "up-regulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "up-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "up-regulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "up-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "up-regulation of SOD" RELATED [GOC:TermGenie] synonym: "up-regulation of SOD-1" RELATED [GOC:TermGenie] synonym: "up-regulation of SOD-2" RELATED [GOC:TermGenie] synonym: "up-regulation of SOD-3" RELATED [GOC:TermGenie] synonym: "up-regulation of SOD-4" RELATED [GOC:TermGenie] synonym: "up-regulation of SODF" RELATED [GOC:TermGenie] synonym: "up-regulation of SODS" RELATED [GOC:TermGenie] synonym: "up-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "up-regulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "up-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "upregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] synonym: "upregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of cuprein" RELATED [GOC:TermGenie] synonym: "upregulation of cytocuprein" RELATED [GOC:TermGenie] synonym: "upregulation of erythrocuprein" RELATED [GOC:TermGenie] synonym: "upregulation of Fe-SOD" RELATED [GOC:TermGenie] synonym: "upregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of hemocuprein" RELATED [GOC:TermGenie] synonym: "upregulation of hepatocuprein" RELATED [GOC:TermGenie] synonym: "upregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "upregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "upregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] synonym: "upregulation of Mn-SOD" RELATED [GOC:TermGenie] synonym: "upregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] synonym: "upregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] synonym: "upregulation of SOD" RELATED [GOC:TermGenie] synonym: "upregulation of SOD-1" RELATED [GOC:TermGenie] synonym: "upregulation of SOD-2" RELATED [GOC:TermGenie] synonym: "upregulation of SOD-3" RELATED [GOC:TermGenie] synonym: "upregulation of SOD-4" RELATED [GOC:TermGenie] synonym: "upregulation of SODF" RELATED [GOC:TermGenie] synonym: "upregulation of SODS" RELATED [GOC:TermGenie] synonym: "upregulation of superoxide dismutase activity" EXACT [GOC:TermGenie] synonym: "upregulation of superoxide dismutase I" RELATED [GOC:TermGenie] synonym: "upregulation of superoxide dismutase II" RELATED [GOC:TermGenie] synonym: "upregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1901668 ! regulation of superoxide dismutase activity is_a: GO:1904833 ! positive regulation of removal of superoxide radicals intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004784 ! superoxide dismutase activity relationship: positively_regulates GO:0004784 ! superoxide dismutase activity created_by: tb creation_date: 2012-11-21T21:36:11Z [Term] id: GO:1901672 name: positive regulation of systemic acquired resistance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of systemic acquired resistance." [GOC:TermGenie] synonym: "activation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] synonym: "activation of systemic acquired resistance" NARROW [GOC:TermGenie] synonym: "positive regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] synonym: "up regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] synonym: "up regulation of systemic acquired resistance" EXACT [GOC:TermGenie] synonym: "up-regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] synonym: "up-regulation of systemic acquired resistance" EXACT [GOC:TermGenie] synonym: "upregulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] synonym: "upregulation of systemic acquired resistance" EXACT [GOC:TermGenie] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009627 ! systemic acquired resistance relationship: positively_regulates GO:0009627 ! systemic acquired resistance created_by: tb creation_date: 2012-11-21T22:03:58Z [Term] id: GO:1901673 name: regulation of mitotic spindle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] synonym: "regulation of spindle assembly involved in mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0060236 ! regulation of mitotic spindle organization is_a: GO:0090169 ! regulation of spindle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090307 ! mitotic spindle assembly relationship: regulates GO:0090307 ! mitotic spindle assembly created_by: al creation_date: 2012-11-22T09:50:00Z [Term] id: GO:1901674 name: regulation of histone H3-K27 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035065 ! regulation of histone acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043974 ! histone H3-K27 acetylation relationship: regulates GO:0043974 ! histone H3-K27 acetylation created_by: vk creation_date: 2012-11-22T12:06:31Z [Term] id: GO:1901675 name: negative regulation of histone H3-K27 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3-K27 acetylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "negative regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "negative regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:1901674 ! regulation of histone H3-K27 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043974 ! histone H3-K27 acetylation relationship: negatively_regulates GO:0043974 ! histone H3-K27 acetylation created_by: vk creation_date: 2012-11-22T12:06:40Z [Term] id: GO:1901676 name: positive regulation of histone H3-K27 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] synonym: "activation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "activation of histone H3-K27 acetylation" NARROW [GOC:TermGenie] synonym: "activation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "positive regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "positive regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:1901674 ! regulation of histone H3-K27 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043974 ! histone H3-K27 acetylation relationship: positively_regulates GO:0043974 ! histone H3-K27 acetylation created_by: vk creation_date: 2012-11-22T12:06:45Z [Term] id: GO:1901678 name: iron coordination entity transport namespace: biological_process def: "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:0006826 ! iron ion transport created_by: pr creation_date: 2012-11-22T15:43:15Z [Term] id: GO:1901679 name: nucleotide transmembrane transport namespace: biological_process def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nucleotide membrane transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0055085 ! transmembrane transport created_by: pr creation_date: 2012-11-22T15:43:23Z [Term] id: GO:1901680 name: sulfur-containing amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:pr, GOC:TermGenie] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity created_by: pr creation_date: 2012-11-22T16:16:48Z [Term] id: GO:1901681 name: sulfur compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sulfur compound." [GOC:pr, GOC:TermGenie] synonym: "sulfur molecular entity binding" EXACT [] is_a: GO:0005488 ! binding created_by: pr creation_date: 2012-11-26T20:45:23Z [Term] id: GO:1901682 name: sulfur compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "sulfur molecular entity transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity created_by: pr creation_date: 2012-11-26T20:45:29Z [Term] id: GO:1901683 name: arsenate ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an arsenate ion from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:1901684 ! arsenate ion transmembrane transport created_by: tb creation_date: 2012-12-04T23:26:27Z [Term] id: GO:1901684 name: arsenate ion transmembrane transport namespace: biological_process def: "The process in which arsenate is transported across a membrane." [GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. is_a: GO:0098656 ! anion transmembrane transport created_by: tb creation_date: 2012-12-04T23:26:36Z [Term] id: GO:1901685 name: glutathione derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione derivative." [GOC:pr, GOC:TermGenie] synonym: "glutathione derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: pr creation_date: 2012-12-05T11:57:11Z [Term] id: GO:1901686 name: glutathione derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutathione derivative." [GOC:pr, GOC:TermGenie] synonym: "glutathione derivative breakdown" EXACT [GOC:TermGenie] synonym: "glutathione derivative catabolism" EXACT [GOC:TermGenie] synonym: "glutathione derivative degradation" EXACT [GOC:TermGenie] is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901685 ! glutathione derivative metabolic process created_by: pr creation_date: 2012-12-05T11:57:16Z [Term] id: GO:1901687 name: glutathione derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione derivative." [GOC:pr, GOC:TermGenie] synonym: "glutathione derivative anabolism" EXACT [GOC:TermGenie] synonym: "glutathione derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "glutathione derivative formation" EXACT [GOC:TermGenie] synonym: "glutathione derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901685 ! glutathione derivative metabolic process created_by: pr creation_date: 2012-12-05T11:57:20Z [Term] id: GO:1901691 name: proton binding namespace: molecular_function def: "Interacting selectively and non-covalently with proton." [GOC:TermGenie] synonym: "hydrogen ion binding" EXACT [GOC:bm] is_a: GO:0043169 ! cation binding created_by: al creation_date: 2012-12-07T13:50:53Z [Term] id: GO:1901692 name: regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990010 ! compound eye retinal cell apoptotic process relationship: regulates GO:1990010 ! compound eye retinal cell apoptotic process created_by: pr creation_date: 2012-12-12T10:28:35Z [Term] id: GO:1901693 name: negative regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process relationship: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process created_by: pr creation_date: 2012-12-12T10:28:40Z [Term] id: GO:1901694 name: positive regulation of compound eye retinal cell apoptotic process namespace: biological_process alt_id: GO:0046675 def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] synonym: "induction of compound eye retinal cell programmed cell death" RELATED [] synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process relationship: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process created_by: pr creation_date: 2012-12-12T10:28:45Z [Term] id: GO:1901695 name: tyramine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyramine." [GOC:TermGenie, PMID:21284755] synonym: "tyramine anabolism" EXACT [GOC:TermGenie] synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie] synonym: "tyramine formation" EXACT [GOC:TermGenie] synonym: "tyramine synthesis" EXACT [GOC:TermGenie] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901162 ! primary amino compound biosynthetic process created_by: tb creation_date: 2012-12-12T19:31:35Z [Term] id: GO:1901696 name: cannabinoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cannabinoid." [GOC:TermGenie] synonym: "cannabinoid anabolism" EXACT [GOC:TermGenie] synonym: "cannabinoid biosynthesis" EXACT [GOC:TermGenie] synonym: "cannabinoid formation" EXACT [GOC:TermGenie] synonym: "cannabinoid synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process created_by: ms creation_date: 2012-12-13T08:07:47Z [Term] id: GO:1901697 name: olivetolic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of olivetolic acid." [GOC:TermGenie] synonym: "olivetolic acid anabolism" EXACT [GOC:TermGenie] synonym: "olivetolic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "olivetolic acid formation" EXACT [GOC:TermGenie] synonym: "olivetolic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process created_by: ms creation_date: 2012-12-13T08:07:51Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound created_by: pr creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901702 name: salt transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0008509 ! anion transmembrane transporter activity created_by: pr creation_date: 2012-12-13T15:14:47Z [Term] id: GO:1901703 name: protein localization involved in auxin polar transport namespace: biological_process def: "Any protein localization that is involved in auxin polar transport." [GOC:TermGenie, PMID:23163883] synonym: "establishment and maintenance of protein localization involved in auxin polar transport" EXACT [GOC:TermGenie] synonym: "protein localisation involved in auxin polar transport" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0009926 ! auxin polar transport relationship: part_of GO:0009926 ! auxin polar transport created_by: tb creation_date: 2012-12-13T19:06:13Z [Term] id: GO:1901704 name: L-glutamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-glutamine." [GOC:TermGenie] synonym: "L-glutamine anabolism" EXACT [GOC:TermGenie] synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie] synonym: "L-glutamine formation" EXACT [GOC:TermGenie] synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006542 ! glutamine biosynthetic process is_a: GO:0017144 ! drug metabolic process created_by: pde creation_date: 2012-12-13T23:32:52Z [Term] id: GO:1901705 name: L-isoleucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-isoleucine." [GOC:TermGenie] synonym: "L-isoleucine anabolism" EXACT [GOC:TermGenie] synonym: "L-isoleucine biosynthesis" EXACT [GOC:TermGenie] synonym: "L-isoleucine formation" EXACT [GOC:TermGenie] synonym: "L-isoleucine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0009097 ! isoleucine biosynthetic process created_by: pde creation_date: 2012-12-13T23:32:56Z [Term] id: GO:1901706 name: mesenchymal cell differentiation involved in bone development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0060348 ! bone development relationship: part_of GO:0060348 ! bone development created_by: hjd creation_date: 2012-12-14T16:04:16Z [Term] id: GO:1901707 name: leptomycin B binding namespace: molecular_function def: "Interacting selectively and non-covalently with leptomycin B." [GOC:TermGenie] is_a: GO:0005504 ! fatty acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: mah creation_date: 2012-12-18T15:10:04Z [Term] id: GO:1901708 name: (+)-3'-hydroxylarreatricin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin." [GOC:TermGenie, pmid:12960376] synonym: "(+)-3'-hydroxylarreatricin anabolism" EXACT [GOC:TermGenie] synonym: "(+)-3'-hydroxylarreatricin biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-3'-hydroxylarreatricin formation" EXACT [GOC:TermGenie] synonym: "(+)-3'-hydroxylarreatricin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process created_by: ms creation_date: 2012-12-19T14:39:32Z [Term] id: GO:1901709 name: (+)-larreatricin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, pmid:12960376] synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms creation_date: 2012-12-19T14:44:29Z [Term] id: GO:1901710 name: regulation of homoserine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] synonym: "regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "regulation of homoserine synthesis" EXACT [GOC:TermGenie] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009090 ! homoserine biosynthetic process relationship: regulates GO:0009090 ! homoserine biosynthetic process created_by: maria.costanzo creation_date: 2012-12-19T16:01:56Z [Term] id: GO:1901711 name: negative regulation of homoserine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] synonym: "down regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "down regulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "downregulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of homoserine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of homoserine formation" EXACT [GOC:TermGenie] synonym: "inhibition of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of homoserine synthesis" EXACT [GOC:TermGenie] is_a: GO:1901710 ! regulation of homoserine biosynthetic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009090 ! homoserine biosynthetic process relationship: negatively_regulates GO:0009090 ! homoserine biosynthetic process created_by: maria.costanzo creation_date: 2012-12-19T16:02:00Z [Term] id: GO:1901712 name: positive regulation of homoserine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] synonym: "activation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "activation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of homoserine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of homoserine formation" EXACT [GOC:TermGenie] synonym: "activation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "up regulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of homoserine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of homoserine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of homoserine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of homoserine formation" EXACT [GOC:TermGenie] synonym: "upregulation of homoserine synthesis" EXACT [GOC:TermGenie] is_a: GO:1901710 ! regulation of homoserine biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009090 ! homoserine biosynthetic process relationship: positively_regulates GO:0009090 ! homoserine biosynthetic process created_by: maria.costanzo creation_date: 2012-12-19T16:02:05Z [Term] id: GO:1901713 name: negative regulation of urea catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process." [GOC:TermGenie] synonym: "down regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "down regulation of urea degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "down-regulation of urea degradation" EXACT [GOC:TermGenie] synonym: "downregulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "downregulation of urea degradation" EXACT [GOC:TermGenie] synonym: "inhibition of urea breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of urea catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of urea catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of urea decomposition" EXACT [GOC:TermGenie] synonym: "inhibition of urea degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "negative regulation of urea degradation" EXACT [GOC:TermGenie] is_a: GO:0034252 ! negative regulation of cellular amide catabolic process is_a: GO:0034254 ! regulation of urea catabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1903315 ! negative regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043419 ! urea catabolic process relationship: negatively_regulates GO:0043419 ! urea catabolic process created_by: maria.costanzo creation_date: 2012-12-19T16:12:13Z [Term] id: GO:1901714 name: positive regulation of urea catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of urea catabolic process." [GOC:TermGenie] synonym: "activation of urea breakdown" EXACT [GOC:TermGenie] synonym: "activation of urea catabolic process" NARROW [GOC:TermGenie] synonym: "activation of urea catabolism" EXACT [GOC:TermGenie] synonym: "activation of urea decomposition" EXACT [GOC:TermGenie] synonym: "activation of urea degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "positive regulation of urea degradation" EXACT [GOC:TermGenie] synonym: "up regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "up regulation of urea degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "up-regulation of urea degradation" EXACT [GOC:TermGenie] synonym: "upregulation of urea breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of urea catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of urea catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of urea decomposition" EXACT [GOC:TermGenie] synonym: "upregulation of urea degradation" EXACT [GOC:TermGenie] is_a: GO:0034253 ! positive regulation of cellular amide catabolic process is_a: GO:0034254 ! regulation of urea catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1903316 ! positive regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043419 ! urea catabolic process relationship: positively_regulates GO:0043419 ! urea catabolic process created_by: maria.costanzo creation_date: 2012-12-19T16:12:18Z [Term] id: GO:1901715 name: regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process relationship: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process created_by: maria.costanzo creation_date: 2012-12-19T16:13:24Z [Term] id: GO:1901716 name: negative regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process relationship: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process created_by: maria.costanzo creation_date: 2012-12-19T16:13:31Z [Term] id: GO:1901717 name: positive regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process relationship: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process created_by: maria.costanzo creation_date: 2012-12-19T16:13:36Z [Term] id: GO:1901718 name: obsolete regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of dipeptide transmembrane transport." [GOC:TermGenie, GOC:vw] comment: The term was obsoleted because it is better represented by a GO-CAM model. is_obsolete: true created_by: pr creation_date: 2012-12-19T17:04:04Z [Term] id: GO:1901719 name: regulation of NMS complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] synonym: "regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] synonym: "regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] is_a: GO:0090234 ! regulation of kinetochore assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044768 ! NMS complex assembly relationship: regulates GO:0044768 ! NMS complex assembly created_by: jl creation_date: 2012-12-20T11:44:17Z [Term] id: GO:1901720 name: negative regulation of NMS complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] synonym: "down regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "down-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "downregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "downregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "downregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "downregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "inhibition of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "inhibition of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "inhibition of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "inhibition of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie] synonym: "negative regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "negative regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "negative regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] synonym: "negative regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] is_a: GO:1901719 ! regulation of NMS complex assembly is_a: GO:1905560 ! negative regulation of kinetochore assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044768 ! NMS complex assembly relationship: negatively_regulates GO:0044768 ! NMS complex assembly created_by: jl creation_date: 2012-12-20T11:44:22Z [Term] id: GO:1901721 name: positive regulation of NMS complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] synonym: "activation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "activation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "activation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "activation of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie] synonym: "positive regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "positive regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "positive regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] synonym: "positive regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "upregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "upregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "upregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] synonym: "upregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] is_a: GO:1901719 ! regulation of NMS complex assembly is_a: GO:1905561 ! positive regulation of kinetochore assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044768 ! NMS complex assembly relationship: positively_regulates GO:0044768 ! NMS complex assembly created_by: jl creation_date: 2012-12-20T11:44:26Z [Term] id: GO:1901722 name: regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072111 ! cell proliferation involved in kidney development relationship: regulates GO:0072111 ! cell proliferation involved in kidney development created_by: krc creation_date: 2012-12-27T19:30:31Z [Term] id: GO:1901723 name: negative regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development relationship: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development created_by: krc creation_date: 2012-12-27T19:30:35Z [Term] id: GO:1901724 name: positive regulation of cell proliferation involved in kidney development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072111 ! cell proliferation involved in kidney development relationship: positively_regulates GO:0072111 ! cell proliferation involved in kidney development created_by: krc creation_date: 2012-12-27T19:30:40Z [Term] id: GO:1901725 name: regulation of histone deacetylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] is_a: GO:0031063 ! regulation of histone deacetylation is_a: GO:0150065 ! regulation of deacetylase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004407 ! histone deacetylase activity relationship: regulates GO:0004407 ! histone deacetylase activity created_by: rl creation_date: 2013-01-07T09:14:12Z [Term] id: GO:1901726 name: negative regulation of histone deacetylase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] synonym: "down regulation of histone deacetylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of histone deacetylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of histone deacetylase activity" EXACT [GOC:TermGenie] synonym: "inhibition of histone deacetylase activity" NARROW [GOC:TermGenie] is_a: GO:0031064 ! negative regulation of histone deacetylation is_a: GO:0150066 ! negative regulation of deacetylase activity is_a: GO:1901725 ! regulation of histone deacetylase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004407 ! histone deacetylase activity relationship: negatively_regulates GO:0004407 ! histone deacetylase activity created_by: rl creation_date: 2013-01-07T09:14:17Z [Term] id: GO:1901727 name: positive regulation of histone deacetylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] synonym: "activation of histone deacetylase activity" NARROW [GOC:TermGenie] synonym: "up regulation of histone deacetylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of histone deacetylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of histone deacetylase activity" EXACT [GOC:TermGenie] is_a: GO:0031065 ! positive regulation of histone deacetylation is_a: GO:0090045 ! positive regulation of deacetylase activity is_a: GO:1901725 ! regulation of histone deacetylase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004407 ! histone deacetylase activity relationship: positively_regulates GO:0004407 ! histone deacetylase activity created_by: rl creation_date: 2013-01-07T09:14:21Z [Term] id: GO:1901728 name: monensin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] synonym: "monensin A metabolism" EXACT [GOC:TermGenie] synonym: "monensin metabolism" EXACT [GOC:yaf] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: yaf creation_date: 2013-01-09T11:55:45Z [Term] id: GO:1901729 name: monensin A catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] synonym: "monensin A breakdown" EXACT [GOC:TermGenie] synonym: "monensin A catabolism" EXACT [GOC:TermGenie] synonym: "monensin A degradation" EXACT [GOC:TermGenie] synonym: "monensin breakdown" EXACT [GOC:yaf] synonym: "monensin catabolism" EXACT [GOC:yaf] synonym: "monensin degradation" EXACT [GOC:yaf] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901728 ! monensin A metabolic process created_by: yaf creation_date: 2013-01-09T11:55:49Z [Term] id: GO:1901730 name: monensin A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] synonym: "monensin A anabolism" EXACT [GOC:TermGenie] synonym: "monensin A biosynthesis" EXACT [GOC:TermGenie] synonym: "monensin A formation" EXACT [GOC:TermGenie] synonym: "monensin A synthesis" EXACT [GOC:TermGenie] synonym: "monensin anabolism" EXACT [GOC:yaf] synonym: "monensin biosynthesis" EXACT [GOC:yaf] synonym: "monensin formation" EXACT [GOC:yaf] synonym: "monensin synthesis" EXACT [GOC:yaf] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901728 ! monensin A metabolic process created_by: yaf creation_date: 2013-01-09T11:55:53Z [Term] id: GO:1901731 name: positive regulation of platelet aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:fj, GOC:TermGenie] synonym: "activation of blood platelet aggregation" NARROW [GOC:TermGenie] synonym: "activation of platelet aggregation" NARROW [GOC:TermGenie] synonym: "activation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "positive regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "positive regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "up regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "up regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "up-regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] synonym: "upregulation of blood platelet aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of platelet aggregation" EXACT [GOC:TermGenie] synonym: "upregulation of thrombocyte aggregation" RELATED [GOC:TermGenie] is_a: GO:0010572 ! positive regulation of platelet activation is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion is_a: GO:0090330 ! regulation of platelet aggregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070527 ! platelet aggregation relationship: positively_regulates GO:0070527 ! platelet aggregation created_by: pr creation_date: 2013-01-10T13:25:39Z [Term] id: GO:1901732 name: quercetin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] synonym: "quercetin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: yaf creation_date: 2013-01-11T10:25:11Z [Term] id: GO:1901733 name: quercetin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] synonym: "quercetin breakdown" EXACT [GOC:TermGenie] synonym: "quercetin catabolism" EXACT [GOC:TermGenie] synonym: "quercetin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1901732 ! quercetin metabolic process created_by: yaf creation_date: 2013-01-11T10:25:15Z [Term] id: GO:1901734 name: quercetin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] synonym: "quercetin anabolism" EXACT [GOC:TermGenie] synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie] synonym: "quercetin formation" EXACT [GOC:TermGenie] synonym: "quercetin synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1901732 ! quercetin metabolic process created_by: yaf creation_date: 2013-01-11T10:25:20Z [Term] id: GO:1901735 name: (R)-mevalonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] synonym: "(R) mevalonate metabolism" EXACT [GOC:yaf] synonym: "(R)-mevalonic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: yaf creation_date: 2013-01-11T11:25:50Z [Term] id: GO:1901736 name: (R)-mevalonic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] synonym: "(R)-mevalonate breakdown" EXACT [MetaCyc:PWY-5074] synonym: "(R)-mevalonate catabolism" EXACT [MetaCyc:PWY-5074] synonym: "(R)-mevalonate degradation" EXACT [MetaCyc:PWY-5074] synonym: "(R)-mevalonic acid breakdown" EXACT [GOC:TermGenie] synonym: "(R)-mevalonic acid catabolism" EXACT [GOC:TermGenie] synonym: "(R)-mevalonic acid degradation" EXACT [GOC:TermGenie] is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1901735 ! (R)-mevalonic acid metabolic process created_by: yaf creation_date: 2013-01-11T11:25:55Z [Term] id: GO:1901737 name: (R)-mevalonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] synonym: "(R)-mevalonate anabolism" EXACT [GOC:yaf] synonym: "(R)-mevalonate biosynthesis" EXACT [GOC:yaf] synonym: "(R)-mevalonate synthesis" EXACT [GOC:yaf] synonym: "(R)-mevalonic acid anabolism" EXACT [GOC:TermGenie] synonym: "(R)-mevalonic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "(R)-mevalonic acid formation" EXACT [GOC:TermGenie] synonym: "(R)-mevalonic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1901735 ! (R)-mevalonic acid metabolic process created_by: yaf creation_date: 2013-01-11T11:25:59Z [Term] id: GO:1901738 name: regulation of vitamin A metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." [GOC:TermGenie, PMID:18093975] synonym: "regulation of vitamin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006776 ! vitamin A metabolic process relationship: regulates GO:0006776 ! vitamin A metabolic process created_by: dph creation_date: 2013-01-11T15:29:43Z [Term] id: GO:1901739 name: regulation of myoblast fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007520 ! myoblast fusion relationship: regulates GO:0007520 ! myoblast fusion created_by: rl creation_date: 2013-01-11T20:23:50Z [Term] id: GO:1901740 name: negative regulation of myoblast fusion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] synonym: "down regulation of myoblast fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of myoblast fusion" EXACT [GOC:TermGenie] synonym: "downregulation of myoblast fusion" EXACT [GOC:TermGenie] synonym: "inhibition of myoblast fusion" NARROW [GOC:TermGenie] is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion is_a: GO:1901739 ! regulation of myoblast fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007520 ! myoblast fusion relationship: negatively_regulates GO:0007520 ! myoblast fusion created_by: rl creation_date: 2013-01-11T20:23:55Z [Term] id: GO:1901741 name: positive regulation of myoblast fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] synonym: "activation of myoblast fusion" NARROW [GOC:TermGenie] synonym: "up regulation of myoblast fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of myoblast fusion" EXACT [GOC:TermGenie] synonym: "upregulation of myoblast fusion" EXACT [GOC:TermGenie] is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion is_a: GO:1901739 ! regulation of myoblast fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007520 ! myoblast fusion relationship: positively_regulates GO:0007520 ! myoblast fusion created_by: rl creation_date: 2013-01-11T20:24:03Z [Term] id: GO:1901742 name: 2-deoxystreptamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf] synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019751 ! polyol metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: yaf creation_date: 2013-01-14T10:01:57Z [Term] id: GO:1901743 name: 2-deoxystreptamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf] synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901742 ! 2-deoxystreptamine metabolic process created_by: yaf creation_date: 2013-01-14T10:02:01Z [Term] id: GO:1901744 name: 2-deoxystreptamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00907] synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901742 ! 2-deoxystreptamine metabolic process created_by: yaf creation_date: 2013-01-14T10:02:06Z [Term] id: GO:1901745 name: prephenate(2-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890] synonym: "prephenate metabolism" EXACT [GOC:yaf] synonym: "prephenate(2-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0043648 ! dicarboxylic acid metabolic process created_by: yaf creation_date: 2013-01-14T10:13:49Z [Term] id: GO:1901746 name: prephenate(2-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890] synonym: "prephenate breakdown" EXACT [GOC:yaf] synonym: "prephenate catabolism" EXACT [GOC:yaf] synonym: "prephenate degradation" EXACT [GOC:yaf] synonym: "prephenate(2-) breakdown" EXACT [GOC:TermGenie] synonym: "prephenate(2-) catabolism" EXACT [GOC:TermGenie] synonym: "prephenate(2-) degradation" EXACT [GOC:TermGenie] is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:1901745 ! prephenate(2-) metabolic process created_by: yaf creation_date: 2013-01-14T10:13:53Z [Term] id: GO:1901747 name: prephenate(2-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890, UniPathway:UPA00120] synonym: "prephenate anabolism" EXACT [GOC:yaf] synonym: "prephenate biosynthesis" EXACT [GOC:yaf] synonym: "prephenate formation" EXACT [GOC:yaf] synonym: "prephenate synthesis" EXACT [GOC:yaf] synonym: "prephenate(2-) anabolism" EXACT [GOC:TermGenie] synonym: "prephenate(2-) biosynthesis" EXACT [GOC:TermGenie] synonym: "prephenate(2-) formation" EXACT [GOC:TermGenie] synonym: "prephenate(2-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:1901745 ! prephenate(2-) metabolic process created_by: yaf creation_date: 2013-01-14T10:13:57Z [Term] id: GO:1901748 name: leukotriene D4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene D4." [GOC:TermGenie, GOC:yaf] synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process created_by: yaf creation_date: 2013-01-14T10:56:12Z [Term] id: GO:1901749 name: leukotriene D4 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leukotriene D4." [GOC:TermGenie, GOC:yaf] synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie] synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie] synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie] is_a: GO:0036100 ! leukotriene catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901748 ! leukotriene D4 metabolic process created_by: yaf creation_date: 2013-01-14T10:56:17Z [Term] id: GO:1901750 name: leukotriene D4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene D4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880] synonym: "leukotriene D4 anabolism" EXACT [GOC:TermGenie] synonym: "leukotriene D4 biosynthesis" EXACT [GOC:TermGenie] synonym: "leukotriene D4 formation" EXACT [GOC:TermGenie] synonym: "leukotriene D4 synthesis" EXACT [GOC:TermGenie] is_a: GO:0019370 ! leukotriene biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901748 ! leukotriene D4 metabolic process created_by: yaf creation_date: 2013-01-14T10:56:21Z [Term] id: GO:1901751 name: leukotriene A4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene A4." [GOC:TermGenie, GOC:yaf] synonym: "leukotriene A4 metabolism" EXACT [GOC:TermGenie] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0031407 ! oxylipin metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: yaf creation_date: 2013-01-14T11:04:56Z [Term] id: GO:1901752 name: leukotriene A4 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leukotriene A4." [GOC:TermGenie, GOC:yaf] synonym: "leukotriene A4 breakdown" EXACT [GOC:TermGenie] synonym: "leukotriene A4 catabolism" EXACT [GOC:TermGenie] synonym: "leukotriene A4 degradation" EXACT [GOC:TermGenie] is_a: GO:0036100 ! leukotriene catabolic process is_a: GO:0042758 ! long-chain fatty acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901751 ! leukotriene A4 metabolic process created_by: yaf creation_date: 2013-01-14T11:05:04Z [Term] id: GO:1901753 name: leukotriene A4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene A4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00877] synonym: "leukotriene A4 anabolism" EXACT [GOC:TermGenie] synonym: "leukotriene A4 biosynthesis" EXACT [GOC:TermGenie] synonym: "leukotriene A4 formation" EXACT [GOC:TermGenie] synonym: "leukotriene A4 synthesis" EXACT [GOC:TermGenie] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019370 ! leukotriene biosynthetic process is_a: GO:0031408 ! oxylipin biosynthetic process is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901751 ! leukotriene A4 metabolic process created_by: yaf creation_date: 2013-01-14T11:05:09Z [Term] id: GO:1901754 name: vitamin D3 catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of vitamin D3." [GOC:TermGenie, GOC:yaf] synonym: "calciol breakdown" EXACT [GOC:TermGenie] synonym: "calciol catabolic process" EXACT [GOC:pr] synonym: "calciol catabolism" EXACT [GOC:TermGenie] synonym: "calciol degradation" EXACT [GOC:TermGenie] synonym: "cholecalciferol catabolic process" EXACT [GOC:pr] synonym: "cholecalciferol catabolism" EXACT [GOC:pr] synonym: "vitamin D3 breakdown" EXACT [GOC:yaf] synonym: "vitamin D3 catabolism" EXACT [GOC:yaf] synonym: "vitamin D3 degradation" EXACT [GOC:yaf] is_a: GO:0042369 ! vitamin D catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0070640 ! vitamin D3 metabolic process created_by: yaf creation_date: 2013-01-14T11:11:04Z [Term] id: GO:1901755 name: vitamin D3 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin D3." [GOC:TermGenie, GOC:yaf, Unipathway:UPA00955] synonym: "calciol anabolism" EXACT [GOC:TermGenie] synonym: "calciol biosynthesis" EXACT [GOC:TermGenie] synonym: "calciol biosynthetic process" EXACT [GOC:pr] synonym: "calciol formation" EXACT [GOC:TermGenie] synonym: "calciol synthesis" EXACT [GOC:TermGenie] synonym: "cholecalciferol biosynthesis" EXACT [GOC:pr] synonym: "cholecalciferol biosynthetic process" EXACT [GOC:pr] synonym: "vitamin D3 anabolism" EXACT [GOC:yaf] synonym: "vitamin D3 biosynthesis" EXACT [GOC:yaf] synonym: "vitamin D3 formation" EXACT [GOC:yaf] synonym: "vitamin D3 synthesis" EXACT [GOC:yaf] is_a: GO:0042368 ! vitamin D biosynthetic process is_a: GO:0070640 ! vitamin D3 metabolic process is_a: GO:0120178 ! steroid hormone biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: yaf creation_date: 2013-01-14T11:11:09Z [Term] id: GO:1901756 name: butirosin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving butirosin." [GOC:TermGenie, GOC:yaf] synonym: "butirosin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019751 ! polyol metabolic process created_by: yaf creation_date: 2013-01-14T11:36:18Z [Term] id: GO:1901757 name: butirosin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of butirosin." [GOC:TermGenie, GOC:yaf] synonym: "butirosin breakdown" EXACT [GOC:TermGenie] synonym: "butirosin catabolism" EXACT [GOC:TermGenie] synonym: "butirosin degradation" EXACT [GOC:TermGenie] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901756 ! butirosin metabolic process created_by: yaf creation_date: 2013-01-14T11:36:22Z [Term] id: GO:1901758 name: butirosin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of butirosin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00964] synonym: "butirosin anabolism" EXACT [GOC:TermGenie] synonym: "butirosin biosynthesis" EXACT [GOC:TermGenie] synonym: "butirosin formation" EXACT [GOC:TermGenie] synonym: "butirosin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901756 ! butirosin metabolic process created_by: yaf creation_date: 2013-01-14T11:36:27Z [Term] id: GO:1901759 name: beta-L-Ara4N-lipid A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-L-Ara4N-lipid A." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326] synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process" EXACT [] synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism" EXACT [] synonym: "beta-L-Ara4N-lipid A metabolism" EXACT [GOC:TermGenie] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:1901269 ! lipooligosaccharide metabolic process created_by: pr creation_date: 2013-01-14T12:52:57Z [Term] id: GO:1901760 name: beta-L-Ara4N-lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326, UniPathway:UPA00037] synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis" EXACT [] synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process" EXACT [] synonym: "beta-L-Ara4N-lipid A anabolism" EXACT [GOC:TermGenie] synonym: "beta-L-Ara4N-lipid A biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-L-Ara4N-lipid A formation" EXACT [GOC:TermGenie] synonym: "beta-L-Ara4N-lipid A synthesis" EXACT [GOC:TermGenie] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:1901271 ! lipooligosaccharide biosynthetic process is_a: GO:1901759 ! beta-L-Ara4N-lipid A metabolic process created_by: pr creation_date: 2013-01-14T12:53:01Z [Term] id: GO:1901761 name: oxytetracycline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168] synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process created_by: yaf creation_date: 2013-01-15T09:52:50Z [Term] id: GO:1901762 name: oxytetracycline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168] synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie] synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie] synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901761 ! oxytetracycline metabolic process created_by: yaf creation_date: 2013-01-15T09:52:55Z [Term] id: GO:1901763 name: oxytetracycline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168, UniPathway:UPA00926] synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie] synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie] synonym: "oxytetracycline formation" EXACT [GOC:TermGenie] synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:1901761 ! oxytetracycline metabolic process created_by: yaf creation_date: 2013-01-15T09:52:59Z [Term] id: GO:1901764 name: phosphinothricin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphinothricin." [GOC:TermGenie, GOC:yaf] synonym: "phosphinothricin metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process created_by: yaf creation_date: 2013-01-15T10:02:37Z [Term] id: GO:1901765 name: phosphinothricin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphinothricin." [GOC:TermGenie, GOC:yaf] synonym: "phosphinothricin breakdown" EXACT [GOC:TermGenie] synonym: "phosphinothricin catabolism" EXACT [GOC:TermGenie] synonym: "phosphinothricin degradation" EXACT [GOC:TermGenie] is_a: GO:1901575 ! organic substance catabolic process is_a: GO:1901764 ! phosphinothricin metabolic process created_by: yaf creation_date: 2013-01-15T10:02:42Z [Term] id: GO:1901766 name: phosphinothricin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphinothricin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00168] synonym: "phosphinothricin anabolism" EXACT [GOC:TermGenie] synonym: "phosphinothricin biosynthesis" EXACT [GOC:TermGenie] synonym: "phosphinothricin formation" EXACT [GOC:TermGenie] synonym: "phosphinothricin synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1901764 ! phosphinothricin metabolic process created_by: yaf creation_date: 2013-01-15T10:02:46Z [Term] id: GO:1901767 name: carbapenem metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024] synonym: "carbapenem metabolism" EXACT [GOC:TermGenie] is_a: GO:0030653 ! beta-lactam antibiotic metabolic process created_by: yaf creation_date: 2013-01-15T10:08:57Z [Term] id: GO:1901768 name: carbapenem catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024] synonym: "carbapenem breakdown" EXACT [GOC:TermGenie] synonym: "carbapenem catabolism" EXACT [GOC:TermGenie] synonym: "carbapenem degradation" EXACT [GOC:TermGenie] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process is_a: GO:1901767 ! carbapenem metabolic process created_by: yaf creation_date: 2013-01-15T10:09:02Z [Term] id: GO:1901769 name: carbapenem biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182] synonym: "carbapenem anabolism" EXACT [GOC:TermGenie] synonym: "carbapenem biosynthesis" EXACT [GOC:TermGenie] synonym: "carbapenem formation" EXACT [GOC:TermGenie] synonym: "carbapenem synthesis" EXACT [GOC:TermGenie] is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process is_a: GO:1901767 ! carbapenem metabolic process created_by: yaf creation_date: 2013-01-15T10:09:06Z [Term] id: GO:1901770 name: daunorubicin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857] synonym: "daunorubicin breakdown" EXACT [GOC:TermGenie] synonym: "daunorubicin catabolism" EXACT [GOC:TermGenie] synonym: "daunorubicin degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044597 ! daunorubicin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901662 ! quinone catabolic process created_by: yaf creation_date: 2013-01-15T10:14:29Z [Term] id: GO:1901771 name: daunorubicin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054] synonym: "daunorubicin anabolism" EXACT [GOC:TermGenie] synonym: "daunorubicin biosynthesis" EXACT [GOC:TermGenie] synonym: "daunorubicin formation" EXACT [GOC:TermGenie] synonym: "daunorubicin synthesis" EXACT [GOC:TermGenie] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0044597 ! daunorubicin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process created_by: yaf creation_date: 2013-01-15T10:14:33Z [Term] id: GO:1901772 name: lincomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249] synonym: "lincomycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: yaf creation_date: 2013-01-15T11:53:52Z [Term] id: GO:1901773 name: lincomycin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249] synonym: "lincomycin breakdown" EXACT [GOC:TermGenie] synonym: "lincomycin catabolism" EXACT [GOC:TermGenie] synonym: "lincomycin degradation" EXACT [GOC:TermGenie] is_a: GO:0016145 ! S-glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901772 ! lincomycin metabolic process created_by: yaf creation_date: 2013-01-15T11:53:57Z [Term] id: GO:1901774 name: lincomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lincomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6955, PMID:8577249, UniPathway:UPA00161] synonym: "lincomycin anabolism" EXACT [GOC:TermGenie] synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "lincomycin formation" EXACT [GOC:TermGenie] synonym: "lincomycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016144 ! S-glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901772 ! lincomycin metabolic process created_by: yaf creation_date: 2013-01-15T11:54:01Z [Term] id: GO:1901775 name: mitomycin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135] synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901661 ! quinone metabolic process created_by: yaf creation_date: 2013-01-15T12:11:48Z [Term] id: GO:1901776 name: mitomycin C catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135] synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie] synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie] synonym: "mitomycin C degradation" EXACT [GOC:TermGenie] is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901662 ! quinone catabolic process is_a: GO:1901775 ! mitomycin C metabolic process created_by: yaf creation_date: 2013-01-15T12:11:52Z [Term] id: GO:1901777 name: mitomycin C biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135, UniPathway:UPA00851] synonym: "mitomycin C anabolism" EXACT [GOC:TermGenie] synonym: "mitomycin C biosynthesis" EXACT [GOC:TermGenie] synonym: "mitomycin C formation" EXACT [GOC:TermGenie] synonym: "mitomycin C synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process is_a: GO:1901775 ! mitomycin C metabolic process created_by: yaf creation_date: 2013-01-15T12:11:57Z [Term] id: GO:1901778 name: pentalenolactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094] synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0097176 ! epoxide metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: yaf creation_date: 2013-01-16T09:49:38Z [Term] id: GO:1901779 name: pentalenolactone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094] synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie] synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie] synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie] is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901335 ! lactone catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901778 ! pentalenolactone metabolic process created_by: yaf creation_date: 2013-01-16T09:49:42Z [Term] id: GO:1901780 name: pentalenolactone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentalenolactone." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6915, PMID:17178094, UniPathway:UPA00974] synonym: "pentalenolactone anabolism" EXACT [GOC:TermGenie] synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie] synonym: "pentalenolactone formation" EXACT [GOC:TermGenie] synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901778 ! pentalenolactone metabolic process created_by: yaf creation_date: 2013-01-16T09:49:47Z [Term] id: GO:1901781 name: p-cumate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713] synonym: "p-cumate metabolism" EXACT [GOC:TermGenie] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: yaf creation_date: 2013-01-16T10:40:28Z [Term] id: GO:1901782 name: p-cumate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-cumate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5273, PMID:8631713, UniPathway:UPA00937] synonym: "p-cumate breakdown" EXACT [GOC:TermGenie] synonym: "p-cumate catabolism" EXACT [GOC:TermGenie] synonym: "p-cumate degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901781 ! p-cumate metabolic process created_by: yaf creation_date: 2013-01-16T10:40:32Z [Term] id: GO:1901783 name: p-cumate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713] synonym: "p-cumate anabolism" EXACT [GOC:TermGenie] synonym: "p-cumate biosynthesis" EXACT [GOC:TermGenie] synonym: "p-cumate formation" EXACT [GOC:TermGenie] synonym: "p-cumate synthesis" EXACT [GOC:TermGenie] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901781 ! p-cumate metabolic process created_by: yaf creation_date: 2013-01-16T10:40:36Z [Term] id: GO:1901784 name: p-cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531] synonym: "p-cresol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0042212 ! cresol metabolic process created_by: yaf creation_date: 2013-01-16T11:03:59Z [Term] id: GO:1901785 name: p-cresol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531, UniPathway:UPA00708] synonym: "p-cresol breakdown" EXACT [GOC:TermGenie] synonym: "p-cresol catabolism" EXACT [GOC:TermGenie] synonym: "p-cresol degradation" EXACT [GOC:TermGenie] is_a: GO:0009407 ! toxin catabolic process is_a: GO:0046199 ! cresol catabolic process is_a: GO:1901784 ! p-cresol metabolic process created_by: yaf creation_date: 2013-01-16T11:04:04Z [Term] id: GO:1901786 name: p-cresol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531] synonym: "p-cresol anabolism" EXACT [GOC:TermGenie] synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie] synonym: "p-cresol formation" EXACT [GOC:TermGenie] synonym: "p-cresol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901784 ! p-cresol metabolic process created_by: yaf creation_date: 2013-01-16T11:04:08Z [Term] id: GO:1901787 name: benzoyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoyl-CoA." [GOC:TermGenie, GOC:yaf] synonym: "benzoyl-CoA metabolism" EXACT [GOC:TermGenie] is_a: GO:0006637 ! acyl-CoA metabolic process created_by: yaf creation_date: 2013-01-16T11:13:54Z [Term] id: GO:1901788 name: benzoyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739] synonym: "benzoyl-CoA breakdown" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA catabolism" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA degradation" EXACT [GOC:TermGenie] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901787 ! benzoyl-CoA metabolic process created_by: yaf creation_date: 2013-01-16T11:13:59Z [Term] id: GO:1901789 name: benzoyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzoyl-CoA." [GOC:TermGenie, GOC:yaf] synonym: "benzoyl-CoA anabolism" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA biosynthesis" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA formation" EXACT [GOC:TermGenie] synonym: "benzoyl-CoA synthesis" EXACT [GOC:TermGenie] is_a: GO:0071616 ! acyl-CoA biosynthetic process is_a: GO:1901787 ! benzoyl-CoA metabolic process created_by: yaf creation_date: 2013-01-16T11:14:03Z [Term] id: GO:1901790 name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY] synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] is_a: GO:0032787 ! monocarboxylic acid metabolic process created_by: yaf creation_date: 2013-01-16T11:40:57Z [Term] id: GO:1901791 name: 3-(2,3-dihydroxyphenyl)propanoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY, UniPathway:UPA00836] synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process created_by: yaf creation_date: 2013-01-16T11:41:02Z [Term] id: GO:1901792 name: 3-(2,3-dihydroxyphenyl)propanoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY] synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie] is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process created_by: yaf creation_date: 2013-01-16T11:41:06Z [Term] id: GO:1901793 name: 3-(3-hydroxyphenyl)propanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203] synonym: "3-(3-hydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] is_a: GO:0032787 ! monocarboxylic acid metabolic process created_by: yaf creation_date: 2013-01-16T11:47:09Z [Term] id: GO:1901794 name: 3-(3-hydroxyphenyl)propanoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY0-1277, PMID:10537203, UniPathway:UPA00835] synonym: "3-(3-hydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process created_by: yaf creation_date: 2013-01-16T11:47:17Z [Term] id: GO:1901795 name: 3-(3-hydroxyphenyl)propanoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203] synonym: "3-(3-hydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie] synonym: "3-(3-hydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie] is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process created_by: yaf creation_date: 2013-01-16T11:47:21Z [Term] id: GO:1901796 name: regulation of signal transduction by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072331 ! signal transduction by p53 class mediator relationship: regulates GO:0072331 ! signal transduction by p53 class mediator created_by: hjd creation_date: 2013-01-18T21:51:39Z [Term] id: GO:1901797 name: negative regulation of signal transduction by p53 class mediator namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] synonym: "down regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "inhibition of signal transduction by p53 class mediator" NARROW [GOC:TermGenie] is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator is_a: GO:1902532 ! negative regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator relationship: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator created_by: hjd creation_date: 2013-01-18T21:51:44Z [Term] id: GO:1901798 name: positive regulation of signal transduction by p53 class mediator namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] synonym: "activation of signal transduction by p53 class mediator" NARROW [GOC:TermGenie] synonym: "up regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator is_a: GO:1902533 ! positive regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072331 ! signal transduction by p53 class mediator relationship: positively_regulates GO:0072331 ! signal transduction by p53 class mediator created_by: hjd creation_date: 2013-01-18T21:51:48Z [Term] id: GO:1901799 name: negative regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] synonym: "down regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010498 ! proteasomal protein catabolic process relationship: negatively_regulates GO:0010498 ! proteasomal protein catabolic process created_by: rl creation_date: 2013-01-21T20:10:54Z [Term] id: GO:1901800 name: positive regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] synonym: "activation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "activation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010498 ! proteasomal protein catabolic process relationship: positively_regulates GO:0010498 ! proteasomal protein catabolic process created_by: rl creation_date: 2013-01-21T20:10:58Z [Term] id: GO:1901801 name: 1,5-anhydro-D-fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] synonym: "1,5-anhydro-D-fructose metabolism" EXACT [GOC:TermGenie] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0019751 ! polyol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: yaf creation_date: 2013-01-22T09:56:20Z [Term] id: GO:1901802 name: 1,5-anhydro-D-fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] synonym: "1,5-anhydro-D-fructose breakdown" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose catabolism" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose degradation" EXACT [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process created_by: yaf creation_date: 2013-01-22T09:56:25Z [Term] id: GO:1901803 name: 1,5-anhydro-D-fructose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] synonym: "1,5-anhydro-D-fructose anabolism" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose biosynthesis" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose formation" EXACT [GOC:TermGenie] synonym: "1,5-anhydro-D-fructose synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process created_by: yaf creation_date: 2013-01-22T09:56:34Z [Term] id: GO:1901804 name: beta-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] synonym: "beta-glucoside metabolism" EXACT [GOC:TermGenie] is_a: GO:0016137 ! glycoside metabolic process created_by: yaf creation_date: 2013-01-22T10:10:21Z [Term] id: GO:1901805 name: beta-glucoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] synonym: "beta-glucoside breakdown" EXACT [GOC:TermGenie] synonym: "beta-glucoside catabolism" EXACT [GOC:TermGenie] synonym: "beta-glucoside degradation" EXACT [GOC:TermGenie] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: yaf creation_date: 2013-01-22T10:10:26Z [Term] id: GO:1901806 name: beta-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] synonym: "beta-glucoside anabolism" EXACT [GOC:TermGenie] synonym: "beta-glucoside biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-glucoside formation" EXACT [GOC:TermGenie] synonym: "beta-glucoside synthesis" EXACT [GOC:TermGenie] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: yaf creation_date: 2013-01-22T10:10:30Z [Term] id: GO:1901807 name: capsanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] synonym: "capsanthin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process created_by: yaf creation_date: 2013-01-22T10:21:39Z [Term] id: GO:1901808 name: capsanthin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] synonym: "capsanthin breakdown" EXACT [GOC:TermGenie] synonym: "capsanthin catabolism" EXACT [GOC:TermGenie] synonym: "capsanthin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:1901807 ! capsanthin metabolic process created_by: yaf creation_date: 2013-01-22T10:21:46Z [Term] id: GO:1901809 name: capsanthin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] synonym: "capsanthin anabolism" EXACT [GOC:TermGenie] synonym: "capsanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "capsanthin formation" EXACT [GOC:TermGenie] synonym: "capsanthin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:1901807 ! capsanthin metabolic process created_by: yaf creation_date: 2013-01-22T10:21:50Z [Term] id: GO:1901810 name: beta-carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] synonym: "beta-carotene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2013-01-22T10:30:23Z [Term] id: GO:1901811 name: beta-carotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] synonym: "beta-carotene breakdown" EXACT [GOC:TermGenie] synonym: "beta-carotene catabolism" EXACT [GOC:TermGenie] synonym: "beta-carotene degradation" EXACT [GOC:TermGenie] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901810 ! beta-carotene metabolic process created_by: yaf creation_date: 2013-01-22T10:30:28Z [Term] id: GO:1901812 name: beta-carotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] synonym: "beta-carotene anabolism" EXACT [GOC:TermGenie] synonym: "beta-carotene biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-carotene formation" EXACT [GOC:TermGenie] synonym: "beta-carotene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901810 ! beta-carotene metabolic process created_by: yaf creation_date: 2013-01-22T10:30:32Z [Term] id: GO:1901813 name: astaxanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process is_a: GO:0017144 ! drug metabolic process created_by: yaf creation_date: 2013-01-22T10:36:59Z [Term] id: GO:1901814 name: astaxanthin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "astaxanthin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901813 ! astaxanthin metabolic process created_by: yaf creation_date: 2013-01-22T10:37:03Z [Term] id: GO:1901815 name: astaxanthin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] synonym: "astaxanthin anabolism" EXACT [GOC:TermGenie] synonym: "astaxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "astaxanthin formation" EXACT [GOC:TermGenie] synonym: "astaxanthin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:1901813 ! astaxanthin metabolic process created_by: yaf creation_date: 2013-01-22T10:37:11Z [Term] id: GO:1901816 name: beta-zeacarotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] synonym: "beta-zeacarotene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2013-01-22T10:42:03Z [Term] id: GO:1901817 name: beta-zeacarotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] synonym: "beta-zeacarotene breakdown" EXACT [GOC:TermGenie] synonym: "beta-zeacarotene catabolism" EXACT [GOC:TermGenie] synonym: "beta-zeacarotene degradation" EXACT [GOC:TermGenie] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901816 ! beta-zeacarotene metabolic process created_by: yaf creation_date: 2013-01-22T10:42:08Z [Term] id: GO:1901818 name: beta-zeacarotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] synonym: "beta-zeacarotene anabolism" EXACT [GOC:TermGenie] synonym: "beta-zeacarotene biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-zeacarotene formation" EXACT [GOC:TermGenie] synonym: "beta-zeacarotene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901816 ! beta-zeacarotene metabolic process created_by: yaf creation_date: 2013-01-22T10:42:12Z [Term] id: GO:1901819 name: alpha-zeacarotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] synonym: "alpha-zeacarotene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2013-01-22T10:51:02Z [Term] id: GO:1901820 name: alpha-zeacarotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] synonym: "alpha-zeacarotene breakdown" EXACT [GOC:TermGenie] synonym: "alpha-zeacarotene catabolism" EXACT [GOC:TermGenie] synonym: "alpha-zeacarotene degradation" EXACT [GOC:TermGenie] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901819 ! alpha-zeacarotene metabolic process created_by: yaf creation_date: 2013-01-22T10:51:06Z [Term] id: GO:1901821 name: alpha-zeacarotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] synonym: "alpha-zeacarotene anabolism" EXACT [GOC:TermGenie] synonym: "alpha-zeacarotene biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-zeacarotene formation" EXACT [GOC:TermGenie] synonym: "alpha-zeacarotene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901819 ! alpha-zeacarotene metabolic process created_by: yaf creation_date: 2013-01-22T10:51:14Z [Term] id: GO:1901822 name: delta-carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] synonym: "delta-carotene metabolism" EXACT [GOC:TermGenie] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0016119 ! carotene metabolic process created_by: yaf creation_date: 2013-01-22T11:17:29Z [Term] id: GO:1901823 name: delta-carotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] synonym: "delta-carotene breakdown" EXACT [GOC:TermGenie] synonym: "delta-carotene catabolism" EXACT [GOC:TermGenie] synonym: "delta-carotene degradation" EXACT [GOC:TermGenie] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016121 ! carotene catabolic process is_a: GO:1901822 ! delta-carotene metabolic process created_by: yaf creation_date: 2013-01-22T11:17:34Z [Term] id: GO:1901824 name: delta-carotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] synonym: "delta-carotene anabolism" EXACT [GOC:TermGenie] synonym: "delta-carotene biosynthesis" EXACT [GOC:TermGenie] synonym: "delta-carotene formation" EXACT [GOC:TermGenie] synonym: "delta-carotene synthesis" EXACT [GOC:TermGenie] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016120 ! carotene biosynthetic process is_a: GO:1901822 ! delta-carotene metabolic process created_by: yaf creation_date: 2013-01-22T11:17:38Z [Term] id: GO:1901825 name: zeaxanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process created_by: yaf creation_date: 2013-01-22T11:36:55Z [Term] id: GO:1901826 name: zeaxanthin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:1901825 ! zeaxanthin metabolic process created_by: yaf creation_date: 2013-01-22T11:37:00Z [Term] id: GO:1901827 name: zeaxanthin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "zeaxanthin formation" EXACT [GOC:TermGenie] synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:1901825 ! zeaxanthin metabolic process created_by: yaf creation_date: 2013-01-22T11:37:07Z [Term] id: GO:1901828 name: zeaxanthin bis(beta-D-glucoside) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] synonym: "zeaxanthin bis(beta-D-glucoside) metabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin diglucoside metabolism" EXACT [GOC:yaf] is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: yaf creation_date: 2013-01-22T12:31:56Z [Term] id: GO:1901829 name: zeaxanthin bis(beta-D-glucoside) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] synonym: "zeaxanthin bis(beta-D-glucoside) breakdown" EXACT [GOC:TermGenie] synonym: "zeaxanthin bis(beta-D-glucoside) catabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin bis(beta-D-glucoside) degradation" EXACT [GOC:TermGenie] synonym: "zeaxanthin diglucoside breakdown" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside catabolism" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside degradation" EXACT [GOC:yaf] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:1901805 ! beta-glucoside catabolic process is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process created_by: yaf creation_date: 2013-01-22T12:32:06Z [Term] id: GO:1901830 name: zeaxanthin bis(beta-D-glucoside) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] synonym: "zeaxanthin bis(beta-D-glucoside) anabolism" EXACT [GOC:TermGenie] synonym: "zeaxanthin bis(beta-D-glucoside) biosynthesis" EXACT [GOC:TermGenie] synonym: "zeaxanthin bis(beta-D-glucoside) formation" EXACT [GOC:TermGenie] synonym: "zeaxanthin bis(beta-D-glucoside) synthesis" EXACT [GOC:TermGenie] synonym: "zeaxanthin diglucoside anabolism" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside biosynthesis" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside formation" EXACT [GOC:yaf] synonym: "zeaxanthin diglucoside synthesis" EXACT [GOC:yaf] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process created_by: yaf creation_date: 2013-01-22T12:32:10Z [Term] id: GO:1901831 name: all-trans-neoxanthin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] synonym: "all-trans-neoxanthin metabolism" EXACT [GOC:TermGenie] synonym: "neoxanthin metabolic process" EXACT [GOC:yaf] synonym: "neoxanthin metabolism" EXACT [GOC:yaf] is_a: GO:0016122 ! xanthophyll metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: yaf creation_date: 2013-01-22T12:43:46Z [Term] id: GO:1901832 name: all-trans-neoxanthin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] synonym: "all-trans-neoxanthin breakdown" EXACT [GOC:TermGenie] synonym: "all-trans-neoxanthin catabolism" EXACT [GOC:TermGenie] synonym: "all-trans-neoxanthin degradation" EXACT [GOC:TermGenie] synonym: "neoxanthin breakdown" EXACT [GOC:yaf] synonym: "neoxanthin catabolic process" EXACT [GOC:yaf] synonym: "neoxanthin catabolism" EXACT [GOC:yaf] synonym: "neoxanthin degradation" EXACT [GOC:yaf] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901831 ! all-trans-neoxanthin metabolic process created_by: yaf creation_date: 2013-01-22T12:43:51Z [Term] id: GO:1901833 name: all-trans-neoxanthin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] synonym: "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie] synonym: "all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie] synonym: "all-trans-neoxanthin formation" EXACT [GOC:TermGenie] synonym: "all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie] synonym: "neoxanthin anabolism" EXACT [GOC:yaf] synonym: "neoxanthin biosynthesis" EXACT [GOC:yaf] synonym: "neoxanthin biosynthetic process" EXACT [GOC:yaf] synonym: "neoxanthin formation" EXACT [GOC:yaf] synonym: "neoxanthin synthesis" EXACT [GOC:yaf] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1901831 ! all-trans-neoxanthin metabolic process created_by: yaf creation_date: 2013-01-22T12:43:56Z [Term] id: GO:1901834 name: regulation of deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie] synonym: "regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] is_a: GO:0061013 ! regulation of mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA created_by: al creation_date: 2013-01-22T22:42:17Z [Term] id: GO:1901835 name: positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie] synonym: "activation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "activation of deadenylation-independent decapping of nuclear-transcribed mRNA" NARROW [GOC:TermGenie] synonym: "activation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] synonym: "positive regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "positive regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] synonym: "up regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] synonym: "up regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] synonym: "up-regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] synonym: "upregulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] synonym: "upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] synonym: "upregulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:1901834 ! regulation of deadenylation-independent decapping of nuclear-transcribed mRNA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA created_by: al creation_date: 2013-01-22T22:42:22Z [Term] id: GO:1901836 name: regulation of transcription of nucleolar large rRNA by RNA polymerase I namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] synonym: "regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] synonym: "regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I relationship: regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I created_by: sart creation_date: 2013-01-23T10:16:27Z [Term] id: GO:1901837 name: negative regulation of transcription of nucleolar large rRNA by RNA polymerase I namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] synonym: "down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "down regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "downregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie] synonym: "inhibition of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] synonym: "negative regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I relationship: negatively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I created_by: sart creation_date: 2013-01-23T10:16:31Z [Term] id: GO:1901838 name: positive regulation of transcription of nucleolar large rRNA by RNA polymerase I namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] synonym: "activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie] synonym: "activation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] synonym: "positive regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "up regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] synonym: "upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] synonym: "upregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I relationship: positively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I created_by: sart creation_date: 2013-01-23T10:16:36Z [Term] id: GO:1901839 name: regulation of RNA polymerase I regulatory region sequence-specific DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie] is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding relationship: regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding created_by: sart creation_date: 2013-01-23T10:24:33Z [Term] id: GO:1901840 name: negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie] synonym: "down regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] is_a: GO:1901839 ! regulation of RNA polymerase I regulatory region sequence-specific DNA binding is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding relationship: negatively_regulates GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding created_by: sart creation_date: 2013-01-23T10:24:37Z [Term] id: GO:1901841 name: regulation of high voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] synonym: "regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008331 ! high voltage-gated calcium channel activity relationship: regulates GO:0008331 ! high voltage-gated calcium channel activity created_by: rl creation_date: 2013-01-24T19:02:15Z [Term] id: GO:1901842 name: negative regulation of high voltage-gated calcium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] synonym: "down regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] is_a: GO:1901386 ! negative regulation of voltage-gated calcium channel activity is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008331 ! high voltage-gated calcium channel activity relationship: negatively_regulates GO:0008331 ! high voltage-gated calcium channel activity created_by: rl creation_date: 2013-01-24T19:02:20Z [Term] id: GO:1901843 name: positive regulation of high voltage-gated calcium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] synonym: "activation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "activation of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] is_a: GO:1901387 ! positive regulation of voltage-gated calcium channel activity is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008331 ! high voltage-gated calcium channel activity relationship: positively_regulates GO:0008331 ! high voltage-gated calcium channel activity created_by: rl creation_date: 2013-01-24T19:02:25Z [Term] id: GO:1901844 name: regulation of cell communication by electrical coupling involved in cardiac conduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] is_a: GO:0010649 ! regulation of cell communication by electrical coupling is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction relationship: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction created_by: rl creation_date: 2013-01-24T19:15:39Z [Term] id: GO:1901845 name: negative regulation of cell communication by electrical coupling involved in cardiac conduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] synonym: "down regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] synonym: "down-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] synonym: "downregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] synonym: "inhibition of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie] is_a: GO:0010651 ! negative regulation of cell communication by electrical coupling is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction is_a: GO:1903780 ! negative regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction relationship: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction created_by: rl creation_date: 2013-01-24T19:15:44Z [Term] id: GO:1901846 name: positive regulation of cell communication by electrical coupling involved in cardiac conduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] synonym: "activation of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie] synonym: "up regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] synonym: "up-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] synonym: "upregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] is_a: GO:0010650 ! positive regulation of cell communication by electrical coupling is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction is_a: GO:1903781 ! positive regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction relationship: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction created_by: rl creation_date: 2013-01-24T19:15:49Z [Term] id: GO:1901847 name: nicotinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] synonym: "nicotinate metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: yaf creation_date: 2013-01-28T11:23:48Z [Term] id: GO:1901848 name: nicotinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] synonym: "nicotinate breakdown" EXACT [GOC:TermGenie] synonym: "nicotinate catabolism" EXACT [GOC:TermGenie] synonym: "nicotinate degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process is_a: GO:1901847 ! nicotinate metabolic process created_by: yaf creation_date: 2013-01-28T11:23:52Z [Term] id: GO:1901849 name: nicotinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] synonym: "nicotinate anabolism" EXACT [GOC:TermGenie] synonym: "nicotinate biosynthesis" EXACT [GOC:TermGenie] synonym: "nicotinate formation" EXACT [GOC:TermGenie] synonym: "nicotinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:1901847 ! nicotinate metabolic process created_by: yaf creation_date: 2013-01-28T11:23:57Z [Term] id: GO:1901850 name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie] synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: yaf creation_date: 2013-01-28T11:38:32Z [Term] id: GO:1901851 name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown" EXACT [GOC:TermGenie] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism" EXACT [GOC:TermGenie] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation" EXACT [GOC:TermGenie] synonym: "coenzyme F0 breakdown" EXACT [GOC:yaf] synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf] synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf] synonym: "coenzyme F0 degradation" EXACT [GOC:yaf] is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process created_by: yaf creation_date: 2013-01-28T11:38:36Z [Term] id: GO:1901852 name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism" EXACT [GOC:TermGenie] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis" EXACT [GOC:TermGenie] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin formation" EXACT [GOC:TermGenie] synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis" EXACT [GOC:TermGenie] synonym: "coenzyme F0 anabolism" EXACT [GOC:yaf] synonym: "coenzyme F0 biosynthesis" EXACT [GOC:yaf] synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf] synonym: "coenzyme F0 formation" EXACT [GOC:yaf] synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process created_by: yaf creation_date: 2013-01-28T11:38:41Z [Term] id: GO:1901853 name: 5,6,7,8-tetrahydrosarcinapterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] synonym: "5,6,7,8-tetrahydrosarcinapterin metabolism" EXACT [GOC:TermGenie] is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:2001117 ! tetrahydromethanopterin metabolic process created_by: yaf creation_date: 2013-01-28T11:47:52Z [Term] id: GO:1901854 name: 5,6,7,8-tetrahydrosarcinapterin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] synonym: "5,6,7,8-tetrahydrosarcinapterin breakdown" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydrosarcinapterin catabolism" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydrosarcinapterin degradation" EXACT [GOC:TermGenie] is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process created_by: yaf creation_date: 2013-01-28T11:48:01Z [Term] id: GO:1901855 name: 5,6,7,8-tetrahydrosarcinapterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] synonym: "5,6,7,8-tetrahydrosarcinapterin anabolism" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydrosarcinapterin biosynthesis" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydrosarcinapterin formation" EXACT [GOC:TermGenie] synonym: "5,6,7,8-tetrahydrosarcinapterin synthesis" EXACT [GOC:TermGenie] is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process created_by: yaf creation_date: 2013-01-28T11:48:05Z [Term] id: GO:1901856 name: negative regulation of cellular respiration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "down regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of respiration" BROAD [GOC:TermGenie] synonym: "down-regulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of respiration" BROAD [GOC:TermGenie] synonym: "downregulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "downregulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of respiration" BROAD [GOC:TermGenie] synonym: "inhibition of cellular respiration" NARROW [GOC:TermGenie] synonym: "inhibition of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of respiration" BROAD [GOC:TermGenie] synonym: "negative regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of respiration" BROAD [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0043457 ! regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045333 ! cellular respiration relationship: negatively_regulates GO:0045333 ! cellular respiration created_by: yaf creation_date: 2013-02-01T09:56:23Z [Term] id: GO:1901857 name: positive regulation of cellular respiration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of cellular respiration" NARROW [GOC:TermGenie] synonym: "activation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "activation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "activation of respiration" BROAD [GOC:TermGenie] synonym: "positive regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of respiration" BROAD [GOC:TermGenie] synonym: "up regulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "up regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of respiration" BROAD [GOC:TermGenie] synonym: "up-regulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of respiration" BROAD [GOC:TermGenie] synonym: "upregulation of cellular respiration" EXACT [GOC:TermGenie] synonym: "upregulation of oxidative metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of oxidative metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of respiration" BROAD [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0043457 ! regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045333 ! cellular respiration relationship: positively_regulates GO:0045333 ! cellular respiration created_by: yaf creation_date: 2013-02-01T09:56:28Z [Term] id: GO:1901858 name: regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:04Z [Term] id: GO:1901859 name: negative regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:09Z [Term] id: GO:1901860 name: positive regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process relationship: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process created_by: yaf creation_date: 2013-02-01T10:05:14Z [Term] id: GO:1901861 name: regulation of muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060537 ! muscle tissue development relationship: regulates GO:0060537 ! muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:47Z [Term] id: GO:1901862 name: negative regulation of muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060537 ! muscle tissue development relationship: negatively_regulates GO:0060537 ! muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:52Z [Term] id: GO:1901863 name: positive regulation of muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060537 ! muscle tissue development relationship: positively_regulates GO:0060537 ! muscle tissue development created_by: yaf creation_date: 2013-02-01T10:30:57Z [Term] id: GO:1901864 name: capsorubin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] synonym: "capsorubin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process created_by: yaf creation_date: 2013-02-04T10:50:13Z [Term] id: GO:1901865 name: capsorubin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] synonym: "capsorubin breakdown" EXACT [GOC:TermGenie] synonym: "capsorubin catabolism" EXACT [GOC:TermGenie] synonym: "capsorubin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process is_a: GO:1901864 ! capsorubin metabolic process created_by: yaf creation_date: 2013-02-04T10:50:17Z [Term] id: GO:1901866 name: capsorubin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] synonym: "capsorubin anabolism" EXACT [GOC:TermGenie] synonym: "capsorubin biosynthesis" EXACT [GOC:TermGenie] synonym: "capsorubin formation" EXACT [GOC:TermGenie] synonym: "capsorubin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016123 ! xanthophyll biosynthetic process is_a: GO:1901864 ! capsorubin metabolic process created_by: yaf creation_date: 2013-02-04T10:50:26Z [Term] id: GO:1901867 name: ecgonine methyl ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:14Z [Term] id: GO:1901868 name: ecgonine methyl ester catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901867 ! ecgonine methyl ester metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:18Z [Term] id: GO:1901869 name: ecgonine methyl ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonine methyl ester anabolism" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester biosynthesis" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester formation" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester synthesis" EXACT [GOC:TermGenie] is_a: GO:0009710 ! tropane alkaloid biosynthetic process is_a: GO:1901867 ! ecgonine methyl ester metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:25Z [Term] id: GO:1901870 name: ecgonone methyl ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonone methyl ester metabolism" EXACT [GOC:TermGenie] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:30Z [Term] id: GO:1901871 name: ecgonone methyl ester catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonone methyl ester breakdown" EXACT [GOC:TermGenie] synonym: "ecgonone methyl ester catabolism" EXACT [GOC:TermGenie] synonym: "ecgonone methyl ester degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901870 ! ecgonone methyl ester metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:34Z [Term] id: GO:1901872 name: ecgonone methyl ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonone methyl ester anabolism" EXACT [GOC:TermGenie] synonym: "ecgonone methyl ester biosynthesis" EXACT [GOC:TermGenie] synonym: "ecgonone methyl ester formation" EXACT [GOC:TermGenie] synonym: "ecgonone methyl ester synthesis" EXACT [GOC:TermGenie] is_a: GO:0009710 ! tropane alkaloid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901870 ! ecgonone methyl ester metabolic process created_by: michel.schneider creation_date: 2013-02-04T11:58:39Z [Term] id: GO:1901873 name: regulation of post-translational protein modification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] synonym: "regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "regulation of PTM" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043687 ! post-translational protein modification relationship: regulates GO:0043687 ! post-translational protein modification created_by: yaf creation_date: 2013-02-05T10:02:52Z [Term] id: GO:1901874 name: negative regulation of post-translational protein modification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] synonym: "down regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "down regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "down regulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "down regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "down regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "down regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "down regulation of PTM" EXACT [GOC:TermGenie] synonym: "down-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "down-regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "down-regulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "down-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "down-regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "down-regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "down-regulation of PTM" EXACT [GOC:TermGenie] synonym: "downregulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "downregulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "downregulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "downregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "downregulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "downregulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "downregulation of PTM" EXACT [GOC:TermGenie] synonym: "inhibition of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "inhibition of post-translational modification" EXACT [GOC:TermGenie] synonym: "inhibition of post-translational protein modification" NARROW [GOC:TermGenie] synonym: "inhibition of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "inhibition of posttranslational modification" EXACT [GOC:TermGenie] synonym: "inhibition of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "inhibition of PTM" EXACT [GOC:TermGenie] synonym: "negative regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "negative regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "negative regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "negative regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "negative regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "negative regulation of PTM" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1901873 ! regulation of post-translational protein modification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043687 ! post-translational protein modification relationship: negatively_regulates GO:0043687 ! post-translational protein modification created_by: yaf creation_date: 2013-02-05T10:02:57Z [Term] id: GO:1901875 name: positive regulation of post-translational protein modification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] synonym: "activation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "activation of post-translational modification" EXACT [GOC:TermGenie] synonym: "activation of post-translational protein modification" NARROW [GOC:TermGenie] synonym: "activation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "activation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "activation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "activation of PTM" EXACT [GOC:TermGenie] synonym: "positive regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "positive regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "positive regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "positive regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "positive regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "positive regulation of PTM" EXACT [GOC:TermGenie] synonym: "up regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "up regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "up regulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "up regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "up regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "up regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "up regulation of PTM" EXACT [GOC:TermGenie] synonym: "up-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "up-regulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "up-regulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "up-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "up-regulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "up-regulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "up-regulation of PTM" EXACT [GOC:TermGenie] synonym: "upregulation of post-translational amino acid modification" EXACT [GOC:TermGenie] synonym: "upregulation of post-translational modification" EXACT [GOC:TermGenie] synonym: "upregulation of post-translational protein modification" EXACT [GOC:TermGenie] synonym: "upregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] synonym: "upregulation of posttranslational modification" EXACT [GOC:TermGenie] synonym: "upregulation of posttranslational protein modification" EXACT [GOC:TermGenie] synonym: "upregulation of PTM" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1901873 ! regulation of post-translational protein modification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043687 ! post-translational protein modification relationship: positively_regulates GO:0043687 ! post-translational protein modification created_by: yaf creation_date: 2013-02-05T10:03:02Z [Term] id: GO:1901876 name: regulation of calcium ion binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005509 ! calcium ion binding relationship: regulates GO:0005509 ! calcium ion binding created_by: rl creation_date: 2013-02-06T12:38:12Z [Term] id: GO:1901877 name: negative regulation of calcium ion binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] synonym: "down regulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "down-regulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "downregulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "inhibition of calcium ion binding" NARROW [GOC:TermGenie] synonym: "inhibition of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "negative regulation of calcium ion storage activity" RELATED [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1901876 ! regulation of calcium ion binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005509 ! calcium ion binding relationship: negatively_regulates GO:0005509 ! calcium ion binding created_by: rl creation_date: 2013-02-06T12:38:22Z [Term] id: GO:1901878 name: positive regulation of calcium ion binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] synonym: "activation of calcium ion binding" NARROW [GOC:TermGenie] synonym: "activation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "positive regulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "up regulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "up-regulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion storage activity" RELATED [GOC:TermGenie] synonym: "upregulation of calcium ion binding" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion storage activity" RELATED [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1901876 ! regulation of calcium ion binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005509 ! calcium ion binding relationship: positively_regulates GO:0005509 ! calcium ion binding created_by: rl creation_date: 2013-02-06T12:38:26Z [Term] id: GO:1901879 name: regulation of protein depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051261 ! protein depolymerization relationship: regulates GO:0051261 ! protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:23Z [Term] id: GO:1901880 name: negative regulation of protein depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051261 ! protein depolymerization relationship: negatively_regulates GO:0051261 ! protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:28Z [Term] id: GO:1901881 name: positive regulation of protein depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie] synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051261 ! protein depolymerization relationship: positively_regulates GO:0051261 ! protein depolymerization created_by: rl creation_date: 2013-02-06T13:57:32Z [Term] id: GO:1901882 name: 4-hydroxycoumarin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] synonym: "4-hydroxycoumarin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009804 ! coumarin metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:05:50Z [Term] id: GO:1901883 name: 4-hydroxycoumarin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] synonym: "4-hydroxycoumarin breakdown" EXACT [GOC:TermGenie] synonym: "4-hydroxycoumarin catabolism" EXACT [GOC:TermGenie] synonym: "4-hydroxycoumarin degradation" EXACT [GOC:TermGenie] is_a: GO:0046226 ! coumarin catabolic process is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:05:54Z [Term] id: GO:1901884 name: 4-hydroxycoumarin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] synonym: "4-hydroxycoumarin anabolism" EXACT [GOC:TermGenie] synonym: "4-hydroxycoumarin biosynthesis" EXACT [GOC:TermGenie] synonym: "4-hydroxycoumarin formation" EXACT [GOC:TermGenie] synonym: "4-hydroxycoumarin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009805 ! coumarin biosynthetic process is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:05:59Z [Term] id: GO:1901885 name: 2-hydroxybenzoyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] synonym: "2-hydroxybenzoyl-CoA metabolism" EXACT [GOC:TermGenie] is_a: GO:0006637 ! acyl-CoA metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:06:03Z [Term] id: GO:1901886 name: 2-hydroxybenzoyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] synonym: "2-hydroxybenzoyl-CoA breakdown" EXACT [GOC:TermGenie] synonym: "2-hydroxybenzoyl-CoA catabolism" EXACT [GOC:TermGenie] synonym: "2-hydroxybenzoyl-CoA degradation" EXACT [GOC:TermGenie] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:06:08Z [Term] id: GO:1901887 name: 2-hydroxybenzoyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] synonym: "2-hydroxybenzoyl-CoA anabolism" EXACT [GOC:TermGenie] synonym: "2-hydroxybenzoyl-CoA biosynthesis" EXACT [GOC:TermGenie] synonym: "2-hydroxybenzoyl-CoA formation" EXACT [GOC:TermGenie] synonym: "2-hydroxybenzoyl-CoA synthesis" EXACT [GOC:TermGenie] is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0071616 ! acyl-CoA biosynthetic process is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process created_by: michel.schneider creation_date: 2013-02-06T14:06:12Z [Term] id: GO:1901888 name: regulation of cell junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034329 ! cell junction assembly relationship: regulates GO:0034329 ! cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:32Z [Term] id: GO:1901889 name: negative regulation of cell junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034329 ! cell junction assembly relationship: negatively_regulates GO:0034329 ! cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:41Z [Term] id: GO:1901890 name: positive regulation of cell junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0034329 ! cell junction assembly relationship: positively_regulates GO:0034329 ! cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:46Z [Term] id: GO:1901891 name: regulation of cell septum assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090529 ! cell septum assembly relationship: regulates GO:0090529 ! cell septum assembly created_by: tb creation_date: 2013-02-06T20:14:40Z [Term] id: GO:1901892 name: negative regulation of cell septum assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] synonym: "down regulation of cell septum assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell septum assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell septum assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cell septum assembly" NARROW [GOC:TermGenie] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901891 ! regulation of cell septum assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090529 ! cell septum assembly relationship: negatively_regulates GO:0090529 ! cell septum assembly created_by: tb creation_date: 2013-02-06T20:14:45Z [Term] id: GO:1901893 name: positive regulation of cell septum assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] synonym: "activation of cell septum assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cell septum assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell septum assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell septum assembly" EXACT [GOC:TermGenie] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901891 ! regulation of cell septum assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090529 ! cell septum assembly relationship: positively_regulates GO:0090529 ! cell septum assembly created_by: tb creation_date: 2013-02-06T20:14:50Z [Term] id: GO:1901894 name: regulation of ATPase-coupled calcium transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] synonym: "regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "regulation of calcium-transporting ATPase activity" EXACT [] synonym: "regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism relationship: regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism created_by: rl creation_date: 2013-02-06T21:18:16Z [Term] id: GO:1901895 name: negative regulation of ATPase-coupled calcium transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] synonym: "down regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "down regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "down regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "down regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "down regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "down regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "down regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "down-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "down-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "down-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "down-regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "down-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "down-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "downregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "downregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "downregulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "downregulation of calcium pump" BROAD [GOC:TermGenie] synonym: "downregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "downregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "downregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "inhibition of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "inhibition of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "inhibition of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "inhibition of calcium pump" BROAD [GOC:TermGenie] synonym: "inhibition of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of calcium-transporting ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "inhibition of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "negative regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "negative regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium-transporting ATPase activity" EXACT [] synonym: "negative regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "negative regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism relationship: negatively_regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism created_by: rl creation_date: 2013-02-06T21:18:25Z [Term] id: GO:1901896 name: positive regulation of ATPase-coupled calcium transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] synonym: "activation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "activation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "activation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "activation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "activation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "activation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "activation of calcium pump" BROAD [GOC:TermGenie] synonym: "activation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "activation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of calcium-transporting ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "activation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "activation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "positive regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "positive regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium-transporting ATPase activity" EXACT [] synonym: "positive regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "positive regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "up regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "up regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "up regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "up regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "up regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "up regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "up regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "up-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "up-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "up-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "up-regulation of calcium pump" BROAD [GOC:TermGenie] synonym: "up-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "up-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] synonym: "upregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] synonym: "upregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ABC transporter" NARROW [GOC:TermGenie] synonym: "upregulation of calcium efflux ATPase" NARROW [GOC:TermGenie] synonym: "upregulation of calcium pump" BROAD [GOC:TermGenie] synonym: "upregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] synonym: "upregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] synonym: "upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] synonym: "upregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism relationship: positively_regulates GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism created_by: rl creation_date: 2013-02-06T21:18:29Z [Term] id: GO:1901897 name: regulation of relaxation of cardiac muscle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] is_a: GO:1901077 ! regulation of relaxation of muscle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055119 ! relaxation of cardiac muscle relationship: regulates GO:0055119 ! relaxation of cardiac muscle created_by: rl creation_date: 2013-02-06T21:26:58Z [Term] id: GO:1901898 name: negative regulation of relaxation of cardiac muscle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] synonym: "down regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] synonym: "down-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] synonym: "downregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] synonym: "inhibition of relaxation of cardiac muscle" NARROW [GOC:TermGenie] is_a: GO:1901078 ! negative regulation of relaxation of muscle is_a: GO:1901897 ! regulation of relaxation of cardiac muscle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055119 ! relaxation of cardiac muscle relationship: negatively_regulates GO:0055119 ! relaxation of cardiac muscle created_by: rl creation_date: 2013-02-06T21:27:02Z [Term] id: GO:1901899 name: positive regulation of relaxation of cardiac muscle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] synonym: "activation of relaxation of cardiac muscle" NARROW [GOC:TermGenie] synonym: "up regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] synonym: "up-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] synonym: "upregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] is_a: GO:1901079 ! positive regulation of relaxation of muscle is_a: GO:1901897 ! regulation of relaxation of cardiac muscle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055119 ! relaxation of cardiac muscle relationship: positively_regulates GO:0055119 ! relaxation of cardiac muscle created_by: rl creation_date: 2013-02-06T21:27:07Z [Term] id: GO:1901900 name: regulation of protein localization to cell division site namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site." [GOC:dph, GOC:TermGenie, PMID:22573892] synonym: "regulation of protein localisation to cell division site" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072741 ! protein localization to cell division site relationship: regulates GO:0072741 ! protein localization to cell division site created_by: dph creation_date: 2013-02-11T12:27:55Z [Term] id: GO:1901901 name: regulation of protein localization to cell division site involved in cytokinesis namespace: biological_process def: "Any regulation of protein localization to cell division site that is involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892] synonym: "regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie] is_a: GO:1901900 ! regulation of protein localization to cell division site intersection_of: GO:1901900 ! regulation of protein localization to cell division site intersection_of: part_of GO:0000910 ! cytokinesis relationship: part_of GO:0000910 ! cytokinesis created_by: dph creation_date: 2013-02-12T18:01:34Z [Term] id: GO:1901902 name: tyrocidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938] synonym: "tyrocidine metabolism" EXACT [GOC:TermGenie] is_a: GO:0008152 ! metabolic process created_by: yaf creation_date: 2013-02-12T23:40:29Z [Term] id: GO:1901903 name: tyrocidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938] synonym: "tyrocidine breakdown" EXACT [GOC:TermGenie] synonym: "tyrocidine catabolism" EXACT [GOC:TermGenie] synonym: "tyrocidine degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901902 ! tyrocidine metabolic process created_by: yaf creation_date: 2013-02-12T23:40:34Z [Term] id: GO:1901904 name: tyrocidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938, UniPathway:UPA00180] synonym: "tyrocidine anabolism" EXACT [GOC:TermGenie] synonym: "tyrocidine biosynthesis" EXACT [GOC:TermGenie] synonym: "tyrocidine formation" EXACT [GOC:TermGenie] synonym: "tyrocidine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901902 ! tyrocidine metabolic process created_by: yaf creation_date: 2013-02-12T23:40:43Z [Term] id: GO:1901905 name: response to tamsulosin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0014075 ! response to amine is_a: GO:0045472 ! response to ether is_a: GO:0060359 ! response to ammonium ion is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2013-02-13T10:14:41Z [Term] id: GO:1901906 name: diadenosine pentaphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752] synonym: "diadenosine pentaphosphate metabolism" EXACT [GOC:pr] synonym: "diadenosyl pentaphosphate metabolic process" EXACT [GOC:pr] synonym: "diadenosyl pentaphosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process created_by: al creation_date: 2013-02-13T13:48:16Z [Term] id: GO:1901907 name: diadenosine pentaphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752] synonym: "diadenosine pentaphosphate catabolism" EXACT [GOC:pr] synonym: "diadenosyl pentaphosphate breakdown" EXACT [GOC:TermGenie] synonym: "diadenosyl pentaphosphate catabolic process" EXACT [GOC:pr] synonym: "diadenosyl pentaphosphate catabolism" EXACT [GOC:TermGenie] synonym: "diadenosyl pentaphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:1901906 ! diadenosine pentaphosphate metabolic process created_by: al creation_date: 2013-02-13T13:48:21Z [Term] id: GO:1901908 name: diadenosine hexaphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752] synonym: "diadenosine hexaphosphate metabolism" EXACT [GOC:pr] synonym: "diadenosyl hexaphosphate metabolic process" EXACT [GOC:pr] synonym: "diadenosyl hexaphosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process created_by: al creation_date: 2013-02-13T13:50:40Z [Term] id: GO:1901909 name: diadenosine hexaphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752] synonym: "diadenosine hexaphosphate catabolism" EXACT [GOC:pr] synonym: "diadenosyl hexaphosphate breakdown" EXACT [GOC:TermGenie] synonym: "diadenosyl hexaphosphate catabolic process" EXACT [GOC:pr] synonym: "diadenosyl hexaphosphate catabolism" EXACT [GOC:TermGenie] synonym: "diadenosyl hexaphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:1901908 ! diadenosine hexaphosphate metabolic process created_by: al creation_date: 2013-02-13T13:50:44Z [Term] id: GO:1901910 name: adenosine 5'-(hexahydrogen pentaphosphate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752] synonym: "adenosine 5'-(hexahydrogen pentaphosphate) metabolism" EXACT [GOC:TermGenie] is_a: GO:0009150 ! purine ribonucleotide metabolic process created_by: al creation_date: 2013-02-13T14:17:59Z [Term] id: GO:1901911 name: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752] synonym: "adenosine 5'-(hexahydrogen pentaphosphate) breakdown" EXACT [GOC:TermGenie] synonym: "adenosine 5'-(hexahydrogen pentaphosphate) catabolism" EXACT [GOC:TermGenie] synonym: "adenosine 5'-(hexahydrogen pentaphosphate) degradation" EXACT [GOC:TermGenie] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:1901910 ! adenosine 5'-(hexahydrogen pentaphosphate) metabolic process created_by: al creation_date: 2013-02-13T14:18:03Z [Term] id: GO:1901913 name: regulation of capsule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] synonym: "regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045230 ! capsule organization relationship: regulates GO:0045230 ! capsule organization created_by: di creation_date: 2013-02-14T06:19:03Z [Term] id: GO:1901914 name: negative regulation of capsule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] synonym: "down regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of capsule organization" EXACT [GOC:TermGenie] synonym: "down regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of capsule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of capsule organization" EXACT [GOC:TermGenie] synonym: "downregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of capsule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of capsule organization" NARROW [GOC:TermGenie] synonym: "inhibition of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901913 ! regulation of capsule organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045230 ! capsule organization relationship: negatively_regulates GO:0045230 ! capsule organization created_by: di creation_date: 2013-02-14T06:19:07Z [Term] id: GO:1901915 name: positive regulation of capsule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] synonym: "activation of capsule organisation" NARROW [GOC:TermGenie] synonym: "activation of capsule organization" NARROW [GOC:TermGenie] synonym: "activation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of capsule organization" EXACT [GOC:TermGenie] synonym: "up regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of capsule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of capsule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of capsule organization" EXACT [GOC:TermGenie] synonym: "upregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901913 ! regulation of capsule organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045230 ! capsule organization relationship: positively_regulates GO:0045230 ! capsule organization created_by: di creation_date: 2013-02-14T06:19:16Z [Term] id: GO:1901916 name: protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis namespace: molecular_function def: "Any protein kinase activity that is involved in regulation of protein localization to cell division site involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892] synonym: "protamine kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" NARROW [GOC:TermGenie] synonym: "protamine kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis" NARROW [GOC:TermGenie] synonym: "protein kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0004672 ! protein kinase activity intersection_of: GO:0004672 ! protein kinase activity intersection_of: part_of GO:1901901 ! regulation of protein localization to cell division site involved in cytokinesis relationship: part_of GO:1901901 ! regulation of protein localization to cell division site involved in cytokinesis created_by: dph creation_date: 2013-02-14T15:30:37Z [Term] id: GO:1901917 name: regulation of exoribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] is_a: GO:0060700 ! regulation of ribonuclease activity is_a: GO:1905777 ! regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004532 ! exoribonuclease activity relationship: regulates GO:0004532 ! exoribonuclease activity created_by: ramab creation_date: 2013-02-15T00:57:56Z [Term] id: GO:1901918 name: negative regulation of exoribonuclease activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] synonym: "down regulation of exoribonuclease activity" EXACT [GOC:TermGenie] synonym: "down-regulation of exoribonuclease activity" EXACT [GOC:TermGenie] synonym: "downregulation of exoribonuclease activity" EXACT [GOC:TermGenie] synonym: "inhibition of exoribonuclease activity" NARROW [GOC:TermGenie] is_a: GO:0060701 ! negative regulation of ribonuclease activity is_a: GO:1901917 ! regulation of exoribonuclease activity is_a: GO:1905778 ! negative regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004532 ! exoribonuclease activity relationship: negatively_regulates GO:0004532 ! exoribonuclease activity created_by: ramab creation_date: 2013-02-15T00:58:03Z [Term] id: GO:1901919 name: positive regulation of exoribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] synonym: "activation of exoribonuclease activity" NARROW [GOC:TermGenie] synonym: "up regulation of exoribonuclease activity" EXACT [GOC:TermGenie] synonym: "up-regulation of exoribonuclease activity" EXACT [GOC:TermGenie] synonym: "upregulation of exoribonuclease activity" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1901917 ! regulation of exoribonuclease activity is_a: GO:1905779 ! positive regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004532 ! exoribonuclease activity relationship: positively_regulates GO:0004532 ! exoribonuclease activity created_by: ramab creation_date: 2013-02-15T00:58:07Z [Term] id: GO:1901920 name: peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity namespace: biological_process def: "Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity." [GOC:TermGenie, PMID:1756737] synonym: "peptidyl-tyrosine dephosphorylation involved in protein kinase activation" RELATED [GOC:TermGenie] is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation intersection_of: GO:0035335 ! peptidyl-tyrosine dephosphorylation intersection_of: part_of GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0032147 ! activation of protein kinase activity created_by: al creation_date: 2013-02-15T18:54:53Z [Term] id: GO:1901921 name: phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex namespace: biological_process def: "Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex." [GOC:TermGenie, PMID:10594013] synonym: "CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex" EXACT [GOC:TermGenie] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain intersection_of: part_of GO:0034402 ! recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex relationship: part_of GO:0034402 ! recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex created_by: ramab creation_date: 2013-02-15T19:09:31Z [Term] id: GO:1901922 name: regulation of sclerotium development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990045 ! sclerotium development relationship: regulates GO:1990045 ! sclerotium development created_by: di creation_date: 2013-02-15T20:00:19Z [Term] id: GO:1901923 name: negative regulation of sclerotium development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] synonym: "down regulation of sclerotium development" EXACT [GOC:TermGenie] synonym: "down-regulation of sclerotium development" EXACT [GOC:TermGenie] synonym: "downregulation of sclerotium development" EXACT [GOC:TermGenie] synonym: "inhibition of sclerotium development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901922 ! regulation of sclerotium development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990045 ! sclerotium development relationship: negatively_regulates GO:1990045 ! sclerotium development created_by: di creation_date: 2013-02-15T20:00:23Z [Term] id: GO:1901924 name: positive regulation of sclerotium development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] synonym: "activation of sclerotium development" NARROW [GOC:TermGenie] synonym: "up regulation of sclerotium development" EXACT [GOC:TermGenie] synonym: "up-regulation of sclerotium development" EXACT [GOC:TermGenie] synonym: "upregulation of sclerotium development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901922 ! regulation of sclerotium development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990045 ! sclerotium development relationship: positively_regulates GO:1990045 ! sclerotium development created_by: di creation_date: 2013-02-15T20:00:28Z [Term] id: GO:1901925 name: negative regulation of protein import into nucleus during spindle assembly checkpoint namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p)." [GOC:dgf, GOC:TermGenie, PMID:23177738] synonym: "Kap121p transport inhibitory pathway" RELATED [] synonym: "KTIP" RELATED [] synonym: "negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint" EXACT [] is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling created_by: pr creation_date: 2013-02-17T20:55:16Z [Term] id: GO:1901926 name: cadinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cadinene." [GOC:TermGenie, pmid:22867794] synonym: "cadinene metabolism" EXACT [GOC:TermGenie] is_a: GO:0051761 ! sesquiterpene metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:22Z [Term] id: GO:1901927 name: cadinene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cadinene." [GOC:TermGenie, pmid:22867794] synonym: "cadinene breakdown" EXACT [GOC:TermGenie] synonym: "cadinene catabolism" EXACT [GOC:TermGenie] synonym: "cadinene degradation" EXACT [GOC:TermGenie] is_a: GO:0051763 ! sesquiterpene catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901926 ! cadinene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:29Z [Term] id: GO:1901928 name: cadinene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cadinene." [GOC:TermGenie, pmid:22867794] synonym: "cadinene anabolism" EXACT [GOC:TermGenie] synonym: "cadinene biosynthesis" EXACT [GOC:TermGenie] synonym: "cadinene formation" EXACT [GOC:TermGenie] synonym: "cadinene synthesis" EXACT [GOC:TermGenie] is_a: GO:0051762 ! sesquiterpene biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901926 ! cadinene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:34Z [Term] id: GO:1901929 name: alpha-copaene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-copaene." [GOC:TermGenie, pmid:22867794] synonym: "alpha-copaene metabolism" EXACT [GOC:TermGenie] is_a: GO:0051761 ! sesquiterpene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:39Z [Term] id: GO:1901930 name: alpha-copaene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-copaene." [GOC:TermGenie, pmid:22867794] synonym: "alpha-copaene breakdown" EXACT [GOC:TermGenie] synonym: "alpha-copaene catabolism" EXACT [GOC:TermGenie] synonym: "alpha-copaene degradation" EXACT [GOC:TermGenie] is_a: GO:0051763 ! sesquiterpene catabolic process is_a: GO:1901929 ! alpha-copaene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:43Z [Term] id: GO:1901931 name: alpha-copaene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-copaene." [GOC:TermGenie, pmid:22867794] synonym: "alpha-copaene anabolism" EXACT [GOC:TermGenie] synonym: "alpha-copaene biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-copaene formation" EXACT [GOC:TermGenie] synonym: "alpha-copaene synthesis" EXACT [GOC:TermGenie] is_a: GO:0051762 ! sesquiterpene biosynthetic process is_a: GO:1901929 ! alpha-copaene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:48Z [Term] id: GO:1901932 name: bicyclogermacrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bicyclogermacrene." [GOC:TermGenie, pmid:22867794] synonym: "bicyclogermacrene metabolism" EXACT [GOC:TermGenie] is_a: GO:0051761 ! sesquiterpene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:52Z [Term] id: GO:1901933 name: bicyclogermacrene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene." [GOC:TermGenie, pmid:22867794] synonym: "bicyclogermacrene breakdown" EXACT [GOC:TermGenie] synonym: "bicyclogermacrene catabolism" EXACT [GOC:TermGenie] synonym: "bicyclogermacrene degradation" EXACT [GOC:TermGenie] is_a: GO:0051763 ! sesquiterpene catabolic process is_a: GO:1901932 ! bicyclogermacrene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:54:57Z [Term] id: GO:1901934 name: bicyclogermacrene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bicyclogermacrene." [GOC:TermGenie, pmid:22867794] synonym: "bicyclogermacrene anabolism" EXACT [GOC:TermGenie] synonym: "bicyclogermacrene biosynthesis" EXACT [GOC:TermGenie] synonym: "bicyclogermacrene formation" EXACT [GOC:TermGenie] synonym: "bicyclogermacrene synthesis" EXACT [GOC:TermGenie] is_a: GO:0051762 ! sesquiterpene biosynthetic process is_a: GO:1901932 ! bicyclogermacrene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:01Z [Term] id: GO:1901935 name: beta-caryophyllene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-caryophyllene." [GOC:TermGenie, pmid:22867794] synonym: "beta-caryophyllene metabolism" EXACT [GOC:TermGenie] is_a: GO:0051761 ! sesquiterpene metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:06Z [Term] id: GO:1901936 name: beta-caryophyllene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene." [GOC:TermGenie, pmid:22867794] synonym: "beta-caryophyllene breakdown" EXACT [GOC:TermGenie] synonym: "beta-caryophyllene catabolism" EXACT [GOC:TermGenie] synonym: "beta-caryophyllene degradation" EXACT [GOC:TermGenie] is_a: GO:0051763 ! sesquiterpene catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901935 ! beta-caryophyllene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:13Z [Term] id: GO:1901937 name: beta-caryophyllene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-caryophyllene." [GOC:TermGenie, pmid:22867794] synonym: "beta-caryophyllene anabolism" EXACT [GOC:TermGenie] synonym: "beta-caryophyllene biosynthesis" EXACT [GOC:TermGenie] synonym: "beta-caryophyllene formation" EXACT [GOC:TermGenie] synonym: "beta-caryophyllene synthesis" EXACT [GOC:TermGenie] is_a: GO:0051762 ! sesquiterpene biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901935 ! beta-caryophyllene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:18Z [Term] id: GO:1901938 name: (-)-exo-alpha-bergamotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] synonym: "(-)-exo-alpha-bergamotene metabolism" EXACT [GOC:TermGenie] is_a: GO:0051761 ! sesquiterpene metabolic process is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:23Z [Term] id: GO:1901939 name: (-)-exo-alpha-bergamotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] synonym: "(-)-exo-alpha-bergamotene breakdown" EXACT [GOC:TermGenie] synonym: "(-)-exo-alpha-bergamotene catabolism" EXACT [GOC:TermGenie] synonym: "(-)-exo-alpha-bergamotene degradation" EXACT [GOC:TermGenie] is_a: GO:0051763 ! sesquiterpene catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:27Z [Term] id: GO:1901940 name: (-)-exo-alpha-bergamotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] synonym: "(-)-exo-alpha-bergamotene anabolism" EXACT [GOC:TermGenie] synonym: "(-)-exo-alpha-bergamotene biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-exo-alpha-bergamotene formation" EXACT [GOC:TermGenie] synonym: "(-)-exo-alpha-bergamotene synthesis" EXACT [GOC:TermGenie] is_a: GO:0051762 ! sesquiterpene biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:32Z [Term] id: GO:1901941 name: (+)-epi-alpha-bisabolol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] synonym: "(+)-epi-alpha-bisabolol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006714 ! sesquiterpenoid metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:36Z [Term] id: GO:1901942 name: (+)-epi-alpha-bisabolol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] synonym: "(+)-epi-alpha-bisabolol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-epi-alpha-bisabolol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-epi-alpha-bisabolol degradation" EXACT [GOC:TermGenie] is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:41Z [Term] id: GO:1901943 name: (+)-epi-alpha-bisabolol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] synonym: "(+)-epi-alpha-bisabolol anabolism" EXACT [GOC:TermGenie] synonym: "(+)-epi-alpha-bisabolol biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-epi-alpha-bisabolol formation" EXACT [GOC:TermGenie] synonym: "(+)-epi-alpha-bisabolol synthesis" EXACT [GOC:TermGenie] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process created_by: michel.schneider creation_date: 2013-02-18T14:55:46Z [Term] id: GO:1901944 name: miltiradiene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving miltiradiene." [GOC:TermGenie, pmid:22027823] synonym: "miltiradiene metabolism" EXACT [GOC:TermGenie] is_a: GO:0042214 ! terpene metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:23Z [Term] id: GO:1901945 name: miltiradiene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of miltiradiene." [GOC:TermGenie, pmid:22027823] synonym: "miltiradiene breakdown" EXACT [GOC:TermGenie] synonym: "miltiradiene catabolism" EXACT [GOC:TermGenie] synonym: "miltiradiene degradation" EXACT [GOC:TermGenie] is_a: GO:0046247 ! terpene catabolic process is_a: GO:1901944 ! miltiradiene metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:27Z [Term] id: GO:1901946 name: miltiradiene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of miltiradiene." [GOC:TermGenie, pmid:22027823] synonym: "miltiradiene anabolism" EXACT [GOC:TermGenie] synonym: "miltiradiene biosynthesis" EXACT [GOC:TermGenie] synonym: "miltiradiene formation" EXACT [GOC:TermGenie] synonym: "miltiradiene synthesis" EXACT [GOC:TermGenie] is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:1901944 ! miltiradiene metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:32Z [Term] id: GO:1901947 name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:41Z [Term] id: GO:1901948 name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown" EXACT [GOC:TermGenie] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism" EXACT [GOC:TermGenie] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:45Z [Term] id: GO:1901949 name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism" EXACT [GOC:TermGenie] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation" EXACT [GOC:TermGenie] synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process created_by: michel.schneider creation_date: 2013-02-18T15:50:50Z [Term] id: GO:1901950 name: dense core granule transport namespace: biological_process def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451] comment: goslim_synapse synonym: "dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0016482 ! cytosolic transport is_a: GO:0032253 ! dense core granule localization is_a: GO:0051650 ! establishment of vesicle localization created_by: pr creation_date: 2013-02-19T13:00:52Z [Term] id: GO:1901951 name: regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport relationship: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:21Z [Term] id: GO:1901952 name: negative regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport relationship: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:30Z [Term] id: GO:1901953 name: positive regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport relationship: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:35Z [Term] id: GO:1901954 name: regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport relationship: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:43Z [Term] id: GO:1901955 name: negative regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport relationship: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:47Z [Term] id: GO:1901956 name: positive regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport relationship: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport created_by: pr creation_date: 2013-02-19T13:36:52Z [Term] id: GO:1901957 name: regulation of cutin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] synonym: "regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "regulation of cutin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010143 ! cutin biosynthetic process relationship: regulates GO:0010143 ! cutin biosynthetic process created_by: tb creation_date: 2013-02-19T19:06:06Z [Term] id: GO:1901958 name: negative regulation of cutin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] synonym: "down regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "down regulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of cutin formation" EXACT [GOC:TermGenie] synonym: "downregulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of cutin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of cutin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of cutin formation" EXACT [GOC:TermGenie] synonym: "inhibition of cutin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of cutin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:1901957 ! regulation of cutin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010143 ! cutin biosynthetic process relationship: negatively_regulates GO:0010143 ! cutin biosynthetic process created_by: tb creation_date: 2013-02-19T19:06:10Z [Term] id: GO:1901959 name: positive regulation of cutin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] synonym: "activation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "activation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of cutin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of cutin formation" EXACT [GOC:TermGenie] synonym: "activation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "up regulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cutin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cutin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of cutin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cutin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of cutin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of cutin formation" EXACT [GOC:TermGenie] synonym: "upregulation of cutin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:1901957 ! regulation of cutin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010143 ! cutin biosynthetic process relationship: positively_regulates GO:0010143 ! cutin biosynthetic process created_by: tb creation_date: 2013-02-19T19:06:19Z [Term] id: GO:1901960 name: isobutanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870] synonym: "isobutanol metabolism" EXACT [GOC:TermGenie] is_a: GO:0034308 ! primary alcohol metabolic process created_by: tt creation_date: 2013-02-19T21:49:44Z [Term] id: GO:1901961 name: isobutanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870] synonym: "isobutanol anabolism" EXACT [GOC:TermGenie] synonym: "isobutanol biosynthesis" EXACT [GOC:TermGenie] synonym: "isobutanol formation" EXACT [GOC:TermGenie] synonym: "isobutanol synthesis" EXACT [GOC:TermGenie] is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:1901960 ! isobutanol metabolic process created_by: tt creation_date: 2013-02-19T21:49:49Z [Term] id: GO:1901962 name: S-adenosyl-L-methionine transmembrane transport namespace: biological_process def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160] synonym: "S-adenosylmethionine transmembrane transport" EXACT [] synonym: "SAM transmembrane transport" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015805 ! S-adenosyl-L-methionine transport created_by: jl creation_date: 2013-02-20T14:45:08Z [Term] id: GO:1901963 name: regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis created_by: dph creation_date: 2013-02-20T20:30:26Z [Term] id: GO:1901964 name: positive regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis relationship: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis created_by: dph creation_date: 2013-02-20T20:30:31Z [Term] id: GO:1901965 name: endoplasmic reticulum to chloroplast transport namespace: biological_process def: "The directed movement of substances from endoplasmic reticulum to chloroplast." [GOC:TermGenie, PMID:18689504] synonym: "ER to chloroplast transport" EXACT [GOC:TermGenie] is_a: GO:0046907 ! intracellular transport created_by: tb creation_date: 2013-02-20T23:48:52Z [Term] id: GO:1901966 name: regulation of cellular response to iron ion starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0065008 ! regulation of biological quality is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010106 ! cellular response to iron ion starvation relationship: regulates GO:0010106 ! cellular response to iron ion starvation created_by: al creation_date: 2013-02-21T11:35:57Z [Term] id: GO:1901967 name: negative regulation of cellular response to iron ion starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244] synonym: "down regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to iron ion starvation" NARROW [GOC:TermGenie] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:1901966 ! regulation of cellular response to iron ion starvation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010106 ! cellular response to iron ion starvation relationship: negatively_regulates GO:0010106 ! cellular response to iron ion starvation created_by: al creation_date: 2013-02-21T11:36:02Z [Term] id: GO:1901968 name: regulation of polynucleotide 3'-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050] synonym: "regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046403 ! polynucleotide 3'-phosphatase activity relationship: regulates GO:0046403 ! polynucleotide 3'-phosphatase activity created_by: tb creation_date: 2013-02-22T00:58:17Z [Term] id: GO:1901969 name: positive regulation of polynucleotide 3'-phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050] synonym: "activation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "activation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "activation of polynucleotide 3'-phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:1901968 ! regulation of polynucleotide 3'-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046403 ! polynucleotide 3'-phosphatase activity relationship: positively_regulates GO:0046403 ! polynucleotide 3'-phosphatase activity created_by: tb creation_date: 2013-02-22T00:58:31Z [Term] id: GO:1901970 name: positive regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation." [GOC:TermGenie, PMID:1846086] synonym: "activation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "activation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "activation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "activation of mitotic sister chromatid separation" NARROW [GOC:TermGenie] synonym: "activation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "positive regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "positive regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "positive regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "up regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "up regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "up regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "up-regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "up-regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "upregulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "upregulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "upregulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:1905820 ! positive regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051306 ! mitotic sister chromatid separation relationship: positively_regulates GO:0051306 ! mitotic sister chromatid separation created_by: al creation_date: 2013-02-22T19:06:19Z [Term] id: GO:1901971 name: regulation of DNA-5-methylcytosine glycosylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050] is_a: GO:1902544 ! regulation of DNA N-glycosylase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity relationship: regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity created_by: tb creation_date: 2013-02-25T20:01:29Z [Term] id: GO:1901972 name: positive regulation of DNA-5-methylcytosine glycosylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050] synonym: "activation of DNA-5-methylcytosine glycosylase activity" NARROW [GOC:TermGenie] synonym: "up regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] is_a: GO:1901971 ! regulation of DNA-5-methylcytosine glycosylase activity is_a: GO:1902546 ! positive regulation of DNA N-glycosylase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity relationship: positively_regulates GO:1990053 ! DNA-5-methylcytosine glycosylase activity created_by: tb creation_date: 2013-02-25T20:01:34Z [Term] id: GO:1901973 name: proline binding namespace: molecular_function def: "Interacting selectively and non-covalently with proline." [GOC:pm, GOC:TermGenie, PMID:7730362] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: pm creation_date: 2013-02-26T14:58:01Z [Term] id: GO:1901974 name: glycerate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerate from one side of a membrane to the other." [GOC:TermGenie, pmid:23382251] is_a: GO:0042879 ! aldonate transmembrane transporter activity relationship: part_of GO:1901975 ! glycerate transmembrane transport created_by: michel.schneider creation_date: 2013-03-05T16:48:45Z [Term] id: GO:1901975 name: glycerate transmembrane transport namespace: biological_process def: "The process in which glycerate is transported across a membrane." [GOC:TermGenie, pmid:23382251] is_a: GO:0042873 ! aldonate transmembrane transport created_by: michel.schneider creation_date: 2013-03-05T16:48:50Z [Term] id: GO:1901976 name: regulation of cell cycle checkpoint namespace: biological_process alt_id: GO:2001047 def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol] synonym: "regulation of G1/S transition checkpoint" RELATED [] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000075 ! cell cycle checkpoint relationship: regulates GO:0000075 ! cell cycle checkpoint created_by: jl creation_date: 2013-03-06T15:10:20Z [Term] id: GO:1901977 name: negative regulation of cell cycle checkpoint namespace: biological_process alt_id: GO:2001048 def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate synonym: "down regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle checkpoint" NARROW [GOC:TermGenie] synonym: "negative regulation of G1/S checkpoint" RELATED [GOC:obol] synonym: "negative regulation of G1/S transition checkpoint" RELATED [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1901976 ! regulation of cell cycle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000075 ! cell cycle checkpoint relationship: negatively_regulates GO:0000075 ! cell cycle checkpoint created_by: jl creation_date: 2013-03-06T15:10:29Z [Term] id: GO:1901978 name: positive regulation of cell cycle checkpoint namespace: biological_process alt_id: GO:2001052 def: "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] synonym: "activation of cell cycle checkpoint" NARROW [GOC:TermGenie] synonym: "positive regulation of G1/S checkpoint" RELATED [GOC:obol] synonym: "positive regulation of G1/S transition checkpoint" RELATED [] synonym: "up regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle checkpoint" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1901976 ! regulation of cell cycle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000075 ! cell cycle checkpoint relationship: positively_regulates GO:0000075 ! cell cycle checkpoint created_by: jl creation_date: 2013-03-06T15:10:34Z [Term] id: GO:1901979 name: regulation of inward rectifier potassium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501] synonym: "regulation of Kir channel activity" EXACT [GOC:TermGenie] is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005242 ! inward rectifier potassium channel activity relationship: regulates GO:0005242 ! inward rectifier potassium channel activity created_by: tb creation_date: 2013-03-12T18:21:12Z [Term] id: GO:1901980 name: positive regulation of inward rectifier potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501] synonym: "activation of inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of Kir channel activity" EXACT [GOC:TermGenie] is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005242 ! inward rectifier potassium channel activity relationship: positively_regulates GO:0005242 ! inward rectifier potassium channel activity created_by: tb creation_date: 2013-03-12T18:21:17Z [Term] id: GO:1901981 name: phosphatidylinositol phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] is_a: GO:0035091 ! phosphatidylinositol binding created_by: tb creation_date: 2013-03-12T18:21:22Z [Term] id: GO:1901982 name: maltose binding namespace: molecular_function def: "Interacting selectively and non-covalently with maltose." [GOC:TermGenie, PMID:21566157] is_a: GO:0048030 ! disaccharide binding created_by: tb creation_date: 2013-03-13T18:17:19Z [Term] id: GO:1901983 name: regulation of protein acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006473 ! protein acetylation relationship: regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:07Z [Term] id: GO:1901984 name: negative regulation of protein acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "down regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein acetylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein amino acid acetylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1901983 ! regulation of protein acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006473 ! protein acetylation relationship: negatively_regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:11Z [Term] id: GO:1901985 name: positive regulation of protein acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] synonym: "activation of protein acetylation" NARROW [GOC:TermGenie] synonym: "activation of protein amino acid acetylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1901983 ! regulation of protein acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006473 ! protein acetylation relationship: positively_regulates GO:0006473 ! protein acetylation created_by: ss creation_date: 2013-03-14T00:40:19Z [Term] id: GO:1901986 name: response to ketamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0072347 ! response to anesthetic is_a: GO:1901654 ! response to ketone created_by: dph creation_date: 2013-03-15T19:16:35Z [Term] id: GO:1901987 name: regulation of cell cycle phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "cell cycle control" EXACT [GOC:vw] synonym: "regulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044770 ! cell cycle phase transition relationship: regulates GO:0044770 ! cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:11:27Z [Term] id: GO:1901988 name: negative regulation of cell cycle phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "down regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "inhibition of cell cycle transition" EXACT [GOC:TermGenie] synonym: "negative regulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044770 ! cell cycle phase transition relationship: negatively_regulates GO:0044770 ! cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:11:32Z [Term] id: GO:1901989 name: positive regulation of cell cycle phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "activation of cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "activation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "positive regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "up regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044770 ! cell cycle phase transition relationship: positively_regulates GO:0044770 ! cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:11:37Z [Term] id: GO:1901990 name: regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] subset: goslim_pombe synonym: "mitotic cell cycle control" EXACT [GOC:vw] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044772 ! mitotic cell cycle phase transition relationship: regulates GO:0044772 ! mitotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:14:38Z [Term] id: GO:1901991 name: negative regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "down regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition relationship: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:14:46Z [Term] id: GO:1901992 name: positive regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "activation of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044772 ! mitotic cell cycle phase transition relationship: positively_regulates GO:0044772 ! mitotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:14:51Z [Term] id: GO:1901993 name: regulation of meiotic cell cycle phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "meiotic cell cycle control" EXACT [GOC:vw] synonym: "regulation of cell cycle transition" BROAD [GOC:TermGenie] is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044771 ! meiotic cell cycle phase transition relationship: regulates GO:0044771 ! meiotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:14:58Z [Term] id: GO:1901994 name: negative regulation of meiotic cell cycle phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "down regulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "down regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "down-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "downregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle transition" BROAD [GOC:TermGenie] synonym: "inhibition of meiotic cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "negative regulation of cell cycle transition" BROAD [GOC:TermGenie] is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition relationship: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:15:03Z [Term] id: GO:1901995 name: positive regulation of meiotic cell cycle phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "activation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "activation of meiotic cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "positive regulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "up regulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "up regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "up-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle transition" BROAD [GOC:TermGenie] synonym: "upregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044771 ! meiotic cell cycle phase transition relationship: positively_regulates GO:0044771 ! meiotic cell cycle phase transition created_by: jl creation_date: 2013-03-19T16:15:08Z [Term] id: GO:1901996 name: regulation of indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040] synonym: "regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] is_a: GO:0010600 ! regulation of auxin biosynthetic process is_a: GO:0090357 ! regulation of tryptophan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan relationship: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan created_by: tb creation_date: 2013-03-19T19:14:09Z [Term] id: GO:1901997 name: negative regulation of indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040] synonym: "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] synonym: "inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie] synonym: "inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] synonym: "negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] synonym: "negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] synonym: "negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] synonym: "negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0090356 ! negative regulation of auxin metabolic process is_a: GO:1901996 ! regulation of indoleacetic acid biosynthetic process via tryptophan intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan relationship: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan created_by: tb creation_date: 2013-03-19T19:14:13Z [Term] id: GO:1901998 name: toxin transport namespace: biological_process def: "The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:17118486] is_a: GO:0006810 ! transport created_by: dph creation_date: 2013-03-19T19:24:55Z [Term] id: GO:1901999 name: homogentisate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homogentisate." [GOC:TermGenie, PMID:22980205] synonym: "homogentisate metabolism" EXACT [GOC:TermGenie] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process created_by: tb creation_date: 2013-03-21T00:01:02Z [Term] id: GO:1902000 name: homogentisate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homogentisate." [GOC:TermGenie, PMID:22980205] synonym: "homogentisate breakdown" EXACT [GOC:TermGenie] synonym: "homogentisate catabolism" EXACT [GOC:TermGenie] synonym: "homogentisate degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901999 ! homogentisate metabolic process created_by: tb creation_date: 2013-03-21T00:01:12Z [Term] id: GO:1902001 name: fatty acid transmembrane transport namespace: biological_process def: "The process in which a fatty acid is transported across a membrane." [GOC:rb, GOC:TermGenie, PMID:9395310] is_a: GO:0015908 ! fatty acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: pr creation_date: 2013-03-21T09:57:00Z [Term] id: GO:1902002 name: obsolete protein phosphorylation involved in cellular protein catabolic process namespace: biological_process def: "OBSOLETE. Any protein phosphorylation that is involved in cellular protein catabolic process." [GOC:rb, GOC:TermGenie, PMID:21098119, PMID:21993622, PMID:23264631] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term, see discussion in https://github.com/geneontology/go-ontology/issues/14137. synonym: "protein amino acid phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "protein amino acid phosphorylation involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "protein amino acid phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "protein amino acid phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie] synonym: "protein phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "protein phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "protein phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2013-03-21T10:08:19Z [Term] id: GO:1902003 name: regulation of amyloid-beta formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871] synonym: "regulation of beta-amyloid formation" EXACT [] is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034205 ! amyloid-beta formation relationship: regulates GO:0034205 ! amyloid-beta formation created_by: dph creation_date: 2013-03-21T19:59:26Z [Term] id: GO:1902004 name: positive regulation of amyloid-beta formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871] synonym: "activation of beta-amyloid formation" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-amyloid formation" EXACT [] synonym: "up regulation of beta-amyloid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-amyloid formation" EXACT [GOC:TermGenie] synonym: "upregulation of beta-amyloid formation" EXACT [GOC:TermGenie] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:1902003 ! regulation of amyloid-beta formation is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034205 ! amyloid-beta formation relationship: positively_regulates GO:0034205 ! amyloid-beta formation created_by: dph creation_date: 2013-03-21T19:59:31Z [Term] id: GO:1902005 name: regulation of proline biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322] synonym: "regulation of proline anabolism" EXACT [GOC:TermGenie] synonym: "regulation of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of proline formation" EXACT [GOC:TermGenie] synonym: "regulation of proline synthesis" EXACT [GOC:TermGenie] is_a: GO:2000214 ! regulation of proline metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006561 ! proline biosynthetic process relationship: regulates GO:0006561 ! proline biosynthetic process created_by: tb creation_date: 2013-03-21T21:48:07Z [Term] id: GO:1902006 name: negative regulation of proline biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322] synonym: "down regulation of proline anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of proline biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of proline formation" EXACT [GOC:TermGenie] synonym: "down regulation of proline synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proline anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proline biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proline formation" EXACT [GOC:TermGenie] synonym: "down-regulation of proline synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proline anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proline biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of proline formation" EXACT [GOC:TermGenie] synonym: "downregulation of proline synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of proline anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of proline biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of proline formation" EXACT [GOC:TermGenie] synonym: "inhibition of proline synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of proline anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proline biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of proline formation" EXACT [GOC:TermGenie] synonym: "negative regulation of proline synthesis" EXACT [GOC:TermGenie] is_a: GO:1902005 ! regulation of proline biosynthetic process is_a: GO:2000215 ! negative regulation of proline metabolic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006561 ! proline biosynthetic process relationship: negatively_regulates GO:0006561 ! proline biosynthetic process created_by: tb creation_date: 2013-03-21T21:48:12Z [Term] id: GO:1902007 name: regulation of toxin transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901998 ! toxin transport relationship: regulates GO:1901998 ! toxin transport created_by: dph creation_date: 2013-03-22T12:53:56Z [Term] id: GO:1902008 name: negative regulation of toxin transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] synonym: "down regulation of toxin transport" EXACT [GOC:TermGenie] synonym: "down-regulation of toxin transport" EXACT [GOC:TermGenie] synonym: "downregulation of toxin transport" EXACT [GOC:TermGenie] synonym: "inhibition of toxin transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1902007 ! regulation of toxin transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901998 ! toxin transport relationship: negatively_regulates GO:1901998 ! toxin transport created_by: dph creation_date: 2013-03-22T12:54:00Z [Term] id: GO:1902009 name: positive regulation of toxin transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] synonym: "activation of toxin transport" NARROW [GOC:TermGenie] synonym: "up regulation of toxin transport" EXACT [GOC:TermGenie] synonym: "up-regulation of toxin transport" EXACT [GOC:TermGenie] synonym: "upregulation of toxin transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1902007 ! regulation of toxin transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901998 ! toxin transport relationship: positively_regulates GO:1901998 ! toxin transport created_by: dph creation_date: 2013-03-22T12:54:09Z [Term] id: GO:1902010 name: negative regulation of translation in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:dph, GOC:TermGenie, PMID:10882126] synonym: "down regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] synonym: "down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "down-regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] synonym: "down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "downregulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] synonym: "downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "inhibition of protein biosynthetic process involved in ER stress response" NARROW [GOC:TermGenie] synonym: "inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "inhibition of protein biosynthetic process involved in response to ER stress" NARROW [GOC:TermGenie] synonym: "negative regulation of protein anabolism involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of protein anabolism involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein anabolism involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthesis involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthesis involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein formation involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of protein formation involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein formation involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein synthesis involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of protein synthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of protein synthesis involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of translation involved in ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of translation involved in response to ER stress" EXACT [GOC:TermGenie] synonym: "protein biosynthesis inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie] synonym: "protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "protein biosynthesis inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie] synonym: "protein biosynthetic process inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie] synonym: "protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "protein biosynthetic process inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress created_by: dph creation_date: 2013-03-22T13:43:26Z [Term] id: GO:1902011 name: poly(ribitol phosphate) teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790] synonym: "poly(ribitol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0046374 ! teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:36Z [Term] id: GO:1902012 name: poly(ribitol phosphate) teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790] synonym: "poly(ribitol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] synonym: "poly(ribitol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(ribitol phosphate) teichoic acid formation" EXACT [GOC:TermGenie] synonym: "poly(ribitol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:1902011 ! poly(ribitol phosphate) teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:40Z [Term] id: GO:1902013 name: poly(glycerol phosphate) teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827] synonym: "poly(glycerol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0046374 ! teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:45Z [Term] id: GO:1902014 name: poly(glycerol phosphate) teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827] synonym: "poly(glycerol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] synonym: "poly(glycerol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(glycerol phosphate) teichoic acid formation" EXACT [GOC:TermGenie] synonym: "poly(glycerol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:1902013 ! poly(glycerol phosphate) teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:50Z [Term] id: GO:1902015 name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process" EXACT [] synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [] is_a: GO:0046374 ! teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:55Z [Term] id: GO:1902016 name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation" EXACT [GOC:TermGenie] synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [] synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process" EXACT [] is_a: GO:0019350 ! teichoic acid biosynthetic process is_a: GO:1902015 ! poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process created_by: tb creation_date: 2013-03-22T15:43:59Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060271 ! cilium assembly relationship: regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060271 ! cilium assembly relationship: negatively_regulates GO:0060271 ! cilium assembly created_by: dph creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902019 name: regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "regulation of ciliary cell motility" RELATED [] synonym: "regulation of cilium cell motility" EXACT [] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060285 ! cilium-dependent cell motility relationship: regulates GO:0060285 ! cilium-dependent cell motility created_by: jl creation_date: 2013-03-27T14:42:38Z [Term] id: GO:1902020 name: negative regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie] synonym: "negative regulation of ciliary cell motility" RELATED [] synonym: "negative regulation of cilium cell motility" EXACT [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060285 ! cilium-dependent cell motility relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility created_by: jl creation_date: 2013-03-27T14:42:42Z [Term] id: GO:1902021 name: regulation of bacterial-type flagellum-dependent cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "regulation of bacterial-type flagellar cell motility" RELATED [] synonym: "regulation of bacterial-type flagellum cell motility" EXACT [] synonym: "regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility relationship: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility created_by: jl creation_date: 2013-03-27T14:42:50Z [Term] id: GO:1902022 name: L-lysine transport namespace: biological_process def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0006812 ! cation transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:06Z [Term] id: GO:1902023 name: L-arginine transport namespace: biological_process alt_id: GO:0043091 def: "The directed movement of a L-arginine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] synonym: "L-arginine import" NARROW [] synonym: "L-arginine uptake" NARROW [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015809 ! arginine transport is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:11Z [Term] id: GO:1902024 name: L-histidine transport namespace: biological_process def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015817 ! histidine transport is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:15Z [Term] id: GO:1902025 name: nitrate import namespace: biological_process def: "The directed movement of nitrate into a cell or organelle." [GOC:TermGenie, PMID:22658680] synonym: "nitrate influx" EXACT [] synonym: "nitrate uptake" EXACT [] is_a: GO:0015706 ! nitrate transport created_by: tb creation_date: 2013-03-27T21:32:58Z [Term] id: GO:1902026 name: regulation of cartilage condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865] is_a: GO:0061035 ! regulation of cartilage development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001502 ! cartilage condensation relationship: regulates GO:0001502 ! cartilage condensation created_by: jl creation_date: 2013-03-28T17:02:42Z [Term] id: GO:1902027 name: positive regulation of cartilage condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865] synonym: "activation of cartilage condensation" NARROW [GOC:TermGenie] synonym: "up regulation of cartilage condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of cartilage condensation" EXACT [GOC:TermGenie] synonym: "upregulation of cartilage condensation" EXACT [GOC:TermGenie] is_a: GO:0061036 ! positive regulation of cartilage development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1902026 ! regulation of cartilage condensation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001502 ! cartilage condensation relationship: positively_regulates GO:0001502 ! cartilage condensation created_by: jl creation_date: 2013-03-28T17:02:46Z [Term] id: GO:1902028 name: regulation of histone H3-K18 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] synonym: "regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035065 ! regulation of histone acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043971 ! histone H3-K18 acetylation relationship: regulates GO:0043971 ! histone H3-K18 acetylation created_by: jl creation_date: 2013-03-28T20:17:39Z [Term] id: GO:1902029 name: positive regulation of histone H3-K18 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] synonym: "activation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "activation of histone H3-K18 acetylation" NARROW [GOC:TermGenie] synonym: "activation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "positive regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "positive regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:1902028 ! regulation of histone H3-K18 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043971 ! histone H3-K18 acetylation relationship: positively_regulates GO:0043971 ! histone H3-K18 acetylation created_by: jl creation_date: 2013-03-28T20:17:44Z [Term] id: GO:1902030 name: negative regulation of histone H3-K18 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] synonym: "down regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3-K18 acetylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone H3K18 acetylation" EXACT [GOC:TermGenie] synonym: "negative regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] synonym: "negative regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:1902028 ! regulation of histone H3-K18 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043971 ! histone H3-K18 acetylation relationship: negatively_regulates GO:0043971 ! histone H3-K18 acetylation created_by: jl creation_date: 2013-03-28T20:19:39Z [Term] id: GO:1902031 name: regulation of NADP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NADP metabolic process." [GOC:TermGenie, PMID:23334421] synonym: "regulation of NAD phosphorylation and dephosphorylation" RELATED [GOC:TermGenie] synonym: "regulation of NADP (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of NADP (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "regulation of NADP (reduced) metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of NADP (reduced) metabolism" EXACT [GOC:TermGenie] synonym: "regulation of NADP metabolism" EXACT [GOC:TermGenie] synonym: "regulation of NADPH metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of NADPH metabolism" EXACT [GOC:TermGenie] synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] synonym: "regulation of oxidized NADP metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of oxidized NADP metabolism" EXACT [GOC:TermGenie] synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] synonym: "regulation of reduced NADP metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of reduced NADP metabolism" EXACT [GOC:TermGenie] synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006739 ! NADP metabolic process relationship: regulates GO:0006739 ! NADP metabolic process created_by: jl creation_date: 2013-03-28T20:21:48Z [Term] id: GO:1902032 name: obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress namespace: biological_process def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in response to osmotic stress." [GOC:kmv, GOC:TermGenie, PMID:18636113] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "global transcription regulation from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic response" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in osmotic response" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in osmotic stress response" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic response" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic stress response" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic response" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic stress response" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in response to osmotic stress" RELATED [GOC:TermGenie] is_obsolete: true created_by: kmv creation_date: 2013-04-01T17:24:04Z [Term] id: GO:1902033 name: regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0072091 ! regulation of stem cell proliferation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071425 ! hematopoietic stem cell proliferation relationship: regulates GO:0071425 ! hematopoietic stem cell proliferation created_by: ss creation_date: 2013-04-02T05:13:19Z [Term] id: GO:1902034 name: negative regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:1903707 ! negative regulation of hemopoiesis is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation relationship: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation created_by: ss creation_date: 2013-04-02T05:13:24Z [Term] id: GO:1902035 name: positive regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:1903708 ! positive regulation of hemopoiesis is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation relationship: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation created_by: ss creation_date: 2013-04-02T05:13:31Z [Term] id: GO:1902036 name: regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060218 ! hematopoietic stem cell differentiation relationship: regulates GO:0060218 ! hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:09Z [Term] id: GO:1902037 name: negative regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation relationship: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:14Z [Term] id: GO:1902038 name: positive regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation created_by: ss creation_date: 2013-04-02T05:19:19Z [Term] id: GO:1902039 name: negative regulation of seed dormancy process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449] synonym: "down regulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "down regulation of seed dormancy process" EXACT [GOC:TermGenie] synonym: "down-regulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "down-regulation of seed dormancy process" EXACT [GOC:TermGenie] synonym: "downregulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "downregulation of seed dormancy process" EXACT [GOC:TermGenie] synonym: "inhibition of seed dormancy" RELATED [GOC:TermGenie] synonym: "inhibition of seed dormancy process" NARROW [GOC:TermGenie] synonym: "negative regulation of seed dormancy" RELATED [GOC:TermGenie] is_a: GO:2000033 ! regulation of seed dormancy process is_a: GO:2000692 ! negative regulation of seed maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010162 ! seed dormancy process relationship: negatively_regulates GO:0010162 ! seed dormancy process created_by: tb creation_date: 2013-04-02T22:13:15Z [Term] id: GO:1902040 name: positive regulation of seed dormancy process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449] synonym: "activation of seed dormancy" RELATED [GOC:TermGenie] synonym: "activation of seed dormancy process" NARROW [GOC:TermGenie] synonym: "positive regulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "up regulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "up regulation of seed dormancy process" EXACT [GOC:TermGenie] synonym: "up-regulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "up-regulation of seed dormancy process" EXACT [GOC:TermGenie] synonym: "upregulation of seed dormancy" RELATED [GOC:TermGenie] synonym: "upregulation of seed dormancy process" EXACT [GOC:TermGenie] is_a: GO:2000033 ! regulation of seed dormancy process is_a: GO:2000693 ! positive regulation of seed maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010162 ! seed dormancy process relationship: positively_regulates GO:0010162 ! seed dormancy process created_by: tb creation_date: 2013-04-02T22:13:20Z [Term] id: GO:1902041 name: regulation of extrinsic apoptotic signaling pathway via death domain receptors namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] synonym: "regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors relationship: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors created_by: lb creation_date: 2013-04-03T07:16:59Z [Term] id: GO:1902042 name: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] synonym: "down regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] synonym: "down-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] synonym: "downregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] synonym: "inhibition of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie] synonym: "negative regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors relationship: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors created_by: lb creation_date: 2013-04-03T07:17:04Z [Term] id: GO:1902043 name: positive regulation of extrinsic apoptotic signaling pathway via death domain receptors namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] synonym: "activation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "activation of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie] synonym: "positive regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] synonym: "up-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] synonym: "upregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors relationship: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors created_by: lb creation_date: 2013-04-03T07:17:11Z [Term] id: GO:1902044 name: regulation of Fas signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] synonym: "regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of FasR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036337 ! Fas signaling pathway relationship: regulates GO:0036337 ! Fas signaling pathway created_by: lb creation_date: 2013-04-03T07:21:23Z [Term] id: GO:1902045 name: negative regulation of Fas signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] synonym: "down regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "down regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "down regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "downregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "downregulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of Apo-1 signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of CD95 signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of Fas receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of FasR signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of FasR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902044 ! regulation of Fas signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036337 ! Fas signaling pathway relationship: negatively_regulates GO:0036337 ! Fas signaling pathway created_by: lb creation_date: 2013-04-03T07:21:28Z [Term] id: GO:1902046 name: positive regulation of Fas signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] synonym: "activation of Apo-1 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of CD95 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of Fas receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of FasR signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of FasR signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of CD95 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Fas signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of FasL signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of FasR signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902044 ! regulation of Fas signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036337 ! Fas signaling pathway relationship: positively_regulates GO:0036337 ! Fas signaling pathway created_by: lb creation_date: 2013-04-03T07:21:33Z [Term] id: GO:1902047 name: polyamine transmembrane transport namespace: biological_process alt_id: GO:1905122 def: "The process in which a polyamine macromolecule is transported across a membrane." [GOC:TermGenie, GOC:vw] synonym: "polyamine import" RELATED [] synonym: "polyamine uptake" RELATED [PMID:23205587] is_a: GO:0015846 ! polyamine transport is_a: GO:0055085 ! transmembrane transport created_by: tb creation_date: 2013-04-03T15:34:57Z [Term] id: GO:1902048 name: neosartoricin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1900619 ! acetate ester metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: di creation_date: 2013-04-08T20:31:02Z [Term] id: GO:1902049 name: neosartoricin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "neosartoricin breakdown" EXACT [GOC:TermGenie] synonym: "neosartoricin catabolism" EXACT [GOC:TermGenie] synonym: "neosartoricin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1902048 ! neosartoricin metabolic process created_by: di creation_date: 2013-04-08T20:31:06Z [Term] id: GO:1902050 name: neosartoricin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "neosartoricin formation" EXACT [GOC:TermGenie] synonym: "neosartoricin synthesis" EXACT [GOC:TermGenie] is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process is_a: GO:1902048 ! neosartoricin metabolic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process created_by: di creation_date: 2013-04-08T20:31:11Z [Term] id: GO:1902051 name: (25S)-Delta(4)-dafachronate binding namespace: molecular_function def: "Interacting selectively and non-covalently with (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:16529801] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:1990239 ! steroid hormone binding created_by: ab creation_date: 2013-04-11T08:33:41Z [Term] id: GO:1902052 name: (25S)-Delta(7)-dafachronate binding namespace: molecular_function def: "Interacting selectively and non-covalently with (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:16529801] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:1990239 ! steroid hormone binding created_by: ab creation_date: 2013-04-11T08:34:38Z [Term] id: GO:1902053 name: regulation of neosartoricin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900732 ! regulation of polyketide biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902050 ! neosartoricin biosynthetic process relationship: regulates GO:1902050 ! neosartoricin biosynthetic process created_by: di creation_date: 2013-04-11T15:46:06Z [Term] id: GO:1902054 name: negative regulation of neosartoricin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "down regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "down regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "downregulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of neosartoricin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "inhibition of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process relationship: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process created_by: di creation_date: 2013-04-11T15:46:15Z [Term] id: GO:1902055 name: positive regulation of neosartoricin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "activation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "activation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of neosartoricin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "activation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "up regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of neosartoricin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of neosartoricin formation" EXACT [GOC:TermGenie] synonym: "upregulation of neosartoricin synthesis" EXACT [GOC:TermGenie] is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902050 ! neosartoricin biosynthetic process relationship: positively_regulates GO:1902050 ! neosartoricin biosynthetic process created_by: di creation_date: 2013-04-11T15:46:20Z [Term] id: GO:1902056 name: (25S)-Delta(7)-dafachronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:22505847] synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042445 ! hormone metabolic process created_by: ab creation_date: 2013-04-13T09:05:27Z [Term] id: GO:1902057 name: (25S)-Delta(4)-dafachronate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:20178781] synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042445 ! hormone metabolic process created_by: ab creation_date: 2013-04-13T09:22:54Z [Term] id: GO:1902058 name: regulation of sporocarp development involved in sexual reproduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] synonym: "regulation of ascus development" NARROW [GOC:TermGenie] synonym: "regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] is_a: GO:0031155 ! regulation of reproductive fruiting body development is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000909 ! sporocarp development involved in sexual reproduction relationship: regulates GO:0000909 ! sporocarp development involved in sexual reproduction created_by: di creation_date: 2013-04-16T04:08:38Z [Term] id: GO:1902059 name: negative regulation of sporocarp development involved in sexual reproduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] synonym: "down regulation of ascus development" NARROW [GOC:TermGenie] synonym: "down regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "down regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "down regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "down regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] synonym: "down-regulation of ascus development" NARROW [GOC:TermGenie] synonym: "down-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "down-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "down-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "down-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] synonym: "downregulation of ascus development" NARROW [GOC:TermGenie] synonym: "downregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "downregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "downregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "downregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] synonym: "inhibition of ascus development" NARROW [GOC:TermGenie] synonym: "inhibition of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "inhibition of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "inhibition of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "inhibition of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie] synonym: "negative regulation of ascus development" NARROW [GOC:TermGenie] synonym: "negative regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "negative regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "negative regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0075262 ! negative regulation of spore-bearing organ development is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction relationship: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction created_by: di creation_date: 2013-04-16T04:08:42Z [Term] id: GO:1902060 name: positive regulation of sporocarp development involved in sexual reproduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] synonym: "activation of ascus development" NARROW [GOC:TermGenie] synonym: "activation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "activation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "activation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "activation of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie] synonym: "positive regulation of ascus development" NARROW [GOC:TermGenie] synonym: "positive regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "positive regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "positive regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "up regulation of ascus development" NARROW [GOC:TermGenie] synonym: "up regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "up regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "up regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "up regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] synonym: "up-regulation of ascus development" NARROW [GOC:TermGenie] synonym: "up-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "up-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "up-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "up-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] synonym: "upregulation of ascus development" NARROW [GOC:TermGenie] synonym: "upregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "upregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] synonym: "upregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] synonym: "upregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0075261 ! positive regulation of spore-bearing organ development is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction relationship: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction created_by: di creation_date: 2013-04-16T04:08:47Z [Term] id: GO:1902061 name: betaine aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] synonym: "betaine aldehyde metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: di creation_date: 2013-04-16T12:07:03Z [Term] id: GO:1902062 name: betaine aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] synonym: "betaine aldehyde breakdown" EXACT [GOC:TermGenie] synonym: "betaine aldehyde catabolism" EXACT [GOC:TermGenie] synonym: "betaine aldehyde degradation" EXACT [GOC:TermGenie] is_a: GO:1901575 ! organic substance catabolic process is_a: GO:1902061 ! betaine aldehyde metabolic process created_by: di creation_date: 2013-04-16T12:07:12Z [Term] id: GO:1902063 name: betaine aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] synonym: "betaine aldehyde anabolism" EXACT [GOC:TermGenie] synonym: "betaine aldehyde biosynthesis" EXACT [GOC:TermGenie] synonym: "betaine aldehyde formation" EXACT [GOC:TermGenie] synonym: "betaine aldehyde synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1902061 ! betaine aldehyde metabolic process created_by: di creation_date: 2013-04-16T12:07:17Z [Term] id: GO:1902064 name: regulation of transcription from RNA polymerase II promoter involved in spermatogenesis namespace: biological_process def: "Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621] synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0022414 ! reproductive process intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: part_of GO:0007283 ! spermatogenesis relationship: part_of GO:0007283 ! spermatogenesis created_by: kmv creation_date: 2013-04-16T20:27:18Z [Term] id: GO:1902065 name: response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009] is_a: GO:0007584 ! response to nutrient is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: tb creation_date: 2013-04-16T21:21:14Z [Term] id: GO:1902066 name: regulation of cell wall pectin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process." [GOC:TermGenie, PMID:23453954] synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052546 ! cell wall pectin metabolic process relationship: regulates GO:0052546 ! cell wall pectin metabolic process created_by: tb creation_date: 2013-04-17T20:05:56Z [Term] id: GO:1902068 name: regulation of sphingolipid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] synonym: "regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090520 ! sphingolipid mediated signaling pathway relationship: regulates GO:0090520 ! sphingolipid mediated signaling pathway created_by: bf creation_date: 2013-04-18T13:24:47Z [Term] id: GO:1902069 name: negative regulation of sphingolipid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] synonym: "down regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway relationship: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway created_by: bf creation_date: 2013-04-18T13:24:51Z [Term] id: GO:1902070 name: positive regulation of sphingolipid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] synonym: "activation of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway relationship: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway created_by: bf creation_date: 2013-04-18T13:24:56Z [Term] id: GO:1902071 name: regulation of hypoxia-inducible factor-1alpha signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie] synonym: "regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1900037 ! regulation of cellular response to hypoxia intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway relationship: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway created_by: bf creation_date: 2013-04-18T13:28:21Z [Term] id: GO:1902072 name: negative regulation of hypoxia-inducible factor-1alpha signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie] synonym: "down regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "down regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "downregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "inhibition of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900038 ! negative regulation of cellular response to hypoxia is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway relationship: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway created_by: bf creation_date: 2013-04-18T13:28:25Z [Term] id: GO:1902073 name: positive regulation of hypoxia-inducible factor-1alpha signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248] synonym: "activation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "activation of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "hypoxic stabilization of HIF1A" NARROW [] synonym: "positive regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "up regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of HIF1alpha pathway" EXACT [GOC:TermGenie] synonym: "upregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900039 ! positive regulation of cellular response to hypoxia is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway relationship: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway created_by: bf creation_date: 2013-04-18T13:28:30Z [Term] id: GO:1902074 name: response to salt namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] synonym: "response to salinity" NARROW [GOC:mls] is_a: GO:0042221 ! response to chemical created_by: mls creation_date: 2013-04-22T15:41:57Z [Term] id: GO:1902075 name: cellular response to salt namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] synonym: "cellular response to salinity" NARROW [GOC:mls] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1902074 ! response to salt created_by: mls creation_date: 2013-04-22T15:42:02Z [Term] id: GO:1902076 name: regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] is_a: GO:1905483 ! regulation of motor neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097477 ! lateral motor column neuron migration relationship: regulates GO:0097477 ! lateral motor column neuron migration created_by: pr creation_date: 2013-04-23T14:42:18Z [Term] id: GO:1902077 name: negative regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] synonym: "down regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "down-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "downregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "inhibition of lateral motor column neuron migration" NARROW [GOC:TermGenie] is_a: GO:1902076 ! regulation of lateral motor column neuron migration is_a: GO:1905484 ! negative regulation of motor neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097477 ! lateral motor column neuron migration relationship: negatively_regulates GO:0097477 ! lateral motor column neuron migration created_by: pr creation_date: 2013-04-23T14:42:23Z [Term] id: GO:1902078 name: positive regulation of lateral motor column neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] synonym: "activation of lateral motor column neuron migration" NARROW [GOC:TermGenie] synonym: "up regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "up-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] synonym: "upregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] is_a: GO:1902076 ! regulation of lateral motor column neuron migration is_a: GO:1905485 ! positive regulation of motor neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097477 ! lateral motor column neuron migration relationship: positively_regulates GO:0097477 ! lateral motor column neuron migration created_by: pr creation_date: 2013-04-23T14:42:28Z [Term] id: GO:1902079 name: D-valine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-valine." [GOC:TermGenie, PMID:23085840] synonym: "D-valine breakdown" EXACT [GOC:TermGenie] synonym: "D-valine catabolism" EXACT [GOC:TermGenie] synonym: "D-valine degradation" EXACT [GOC:TermGenie] is_a: GO:0006574 ! valine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:1902114 ! D-valine metabolic process created_by: al creation_date: 2013-04-23T21:34:29Z [Term] id: GO:1902080 name: regulation of calcium ion import into sarcoplasmic reticulum namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0090279 ! regulation of calcium ion import intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum relationship: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum created_by: rl creation_date: 2013-04-24T16:07:50Z [Term] id: GO:1902081 name: negative regulation of calcium ion import into sarcoplasmic reticulum namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] synonym: "down regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0090281 ! negative regulation of calcium ion import is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum relationship: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum created_by: rl creation_date: 2013-04-24T16:07:59Z [Term] id: GO:1902082 name: positive regulation of calcium ion import into sarcoplasmic reticulum namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] synonym: "activation of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0090280 ! positive regulation of calcium ion import is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum relationship: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum created_by: rl creation_date: 2013-04-24T16:08:03Z [Term] id: GO:1902083 name: negative regulation of peptidyl-cysteine S-nitrosylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19198614] synonym: "down regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] synonym: "down regulation of S-nitrosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of S-nitrosylation" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein S-nitrosylation" EXACT [GOC:TermGenie] synonym: "downregulation of S-nitrosylation" EXACT [GOC:TermGenie] synonym: "inhibition of peptidyl-cysteine S-nitrosylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein S-nitrosylation" EXACT [GOC:TermGenie] synonym: "inhibition of S-nitrosylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] synonym: "negative regulation of S-nitrosylation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation relationship: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation created_by: rl creation_date: 2013-04-24T16:49:34Z [Term] id: GO:1902084 name: fumagillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "fumagillin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: di creation_date: 2013-04-25T14:00:41Z [Term] id: GO:1902085 name: fumagillin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "fumagillin breakdown" EXACT [GOC:TermGenie] synonym: "fumagillin catabolism" EXACT [GOC:TermGenie] synonym: "fumagillin degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1902084 ! fumagillin metabolic process created_by: di creation_date: 2013-04-25T14:00:45Z [Term] id: GO:1902086 name: fumagillin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "fumagillin formation" EXACT [GOC:TermGenie] synonym: "fumagillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902084 ! fumagillin metabolic process created_by: di creation_date: 2013-04-25T14:00:50Z [Term] id: GO:1902087 name: dimethylsulfoniopropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin." [GOC:jh2, GOC:TermGenie, PMID:19807777] synonym: "S,S-dimethyl-beta-propiothetin breakdown" EXACT [GOC:TermGenie] synonym: "S,S-dimethyl-beta-propiothetin catabolic process" EXACT [] synonym: "S,S-dimethyl-beta-propiothetin catabolism" EXACT [GOC:TermGenie] synonym: "S,S-dimethyl-beta-propiothetin degradation" EXACT [GOC:TermGenie] is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: tb creation_date: 2013-04-26T17:29:13Z [Term] id: GO:1902088 name: plant-type cell wall loosening involved in abscission namespace: biological_process def: "Any plant-type cell wall loosening that is involved in abscission." [GOC:TermGenie, PMID:23479623] synonym: "cellulose and pectin-containing cell wall loosening involved in abscission" EXACT [GOC:TermGenie] is_a: GO:0009828 ! plant-type cell wall loosening is_a: GO:0009830 ! cell wall modification involved in abscission intersection_of: GO:0009828 ! plant-type cell wall loosening intersection_of: part_of GO:0009838 ! abscission created_by: tb creation_date: 2013-04-26T18:34:45Z [Term] id: GO:1902089 name: cell wall polysaccharide catabolic process involved in lateral root development namespace: biological_process def: "Any cell wall polysaccharide catabolic process that is involved in lateral root development." [GOC:TermGenie, PMID:23479623] synonym: "cell wall polysaccharide breakdown involved in lateral root development" EXACT [GOC:TermGenie] is_a: GO:0044347 ! cell wall polysaccharide catabolic process intersection_of: GO:0044347 ! cell wall polysaccharide catabolic process intersection_of: part_of GO:0048527 ! lateral root development relationship: part_of GO:0048527 ! lateral root development created_by: tb creation_date: 2013-04-26T18:34:53Z [Term] id: GO:1902090 name: regulation of fumagillin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "regulation of fumagillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902086 ! fumagillin biosynthetic process relationship: regulates GO:1902086 ! fumagillin biosynthetic process created_by: di creation_date: 2013-04-27T03:44:59Z [Term] id: GO:1902091 name: negative regulation of fumagillin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "down regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "down regulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "downregulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of fumagillin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of fumagillin formation" EXACT [GOC:TermGenie] synonym: "inhibition of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of fumagillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1902090 ! regulation of fumagillin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902086 ! fumagillin biosynthetic process relationship: negatively_regulates GO:1902086 ! fumagillin biosynthetic process created_by: di creation_date: 2013-04-27T03:45:04Z [Term] id: GO:1902092 name: positive regulation of fumagillin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "activation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "activation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of fumagillin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "activation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "up regulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of fumagillin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of fumagillin formation" EXACT [GOC:TermGenie] synonym: "upregulation of fumagillin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1902090 ! regulation of fumagillin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902086 ! fumagillin biosynthetic process relationship: positively_regulates GO:1902086 ! fumagillin biosynthetic process created_by: di creation_date: 2013-04-27T03:45:09Z [Term] id: GO:1902093 name: positive regulation of flagellated sperm motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657] synonym: "activation of sperm motility" NARROW [GOC:TermGenie] synonym: "activation of sperm movement" BROAD [GOC:TermGenie] synonym: "positive regulation of sperm motility" BROAD [] synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie] is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030317 ! flagellated sperm motility relationship: positively_regulates GO:0030317 ! flagellated sperm motility created_by: bf creation_date: 2013-04-29T09:15:25Z [Term] id: GO:1902097 name: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium." [GOC:kmv, GOC:TermGenie, PMID:17183709] synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0050829 ! defense response to Gram-negative bacterium relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium created_by: kmv creation_date: 2013-04-30T16:54:30Z [Term] id: GO:1902098 name: calcitriol binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3." [GOC:TermGenie, PMID:21872797, Wikipedia:Calcitriol_receptor] synonym: "1,25-dihydroxycholecalciferol binding" EXACT [Wikipedia:Calcitriol] synonym: "1,25-dihydroxyvitamin D3 binding" EXACT [Wikipedia:Calcitriol] synonym: "1alpha,25(OH)2 vitamin D3 binding" EXACT [PMID:21872797] synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823] synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823] synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823] synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf] is_a: GO:0008144 ! drug binding is_a: GO:0042562 ! hormone binding is_a: GO:1902271 ! D3 vitamins binding created_by: bf creation_date: 2013-05-02T09:41:15Z [Term] id: GO:1902099 name: regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle created_by: jl creation_date: 2013-05-02T12:45:15Z [Term] id: GO:1902100 name: negative regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "inhibition of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle created_by: jl creation_date: 2013-05-02T12:45:20Z [Term] id: GO:1902101 name: positive regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] synonym: "up regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle created_by: jl creation_date: 2013-05-02T12:45:30Z [Term] id: GO:1902102 name: regulation of metaphase/anaphase transition of meiotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle is_a: GO:1905132 ! regulation of meiotic chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle relationship: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle created_by: jl creation_date: 2013-05-02T12:45:38Z [Term] id: GO:1902103 name: negative regulation of metaphase/anaphase transition of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "down regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "downregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "inhibition of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie] synonym: "negative regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905133 ! negative regulation of meiotic chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle relationship: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle created_by: jl creation_date: 2013-05-02T12:45:43Z [Term] id: GO:1902104 name: positive regulation of metaphase/anaphase transition of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "activation of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie] synonym: "positive regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "up regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "up regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] synonym: "upregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905134 ! positive regulation of meiotic chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle relationship: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle created_by: jl creation_date: 2013-05-02T12:45:48Z [Term] id: GO:1902105 name: regulation of leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002521 ! leukocyte differentiation relationship: regulates GO:0002521 ! leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:42Z [Term] id: GO:1902106 name: negative regulation of leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002521 ! leukocyte differentiation relationship: negatively_regulates GO:0002521 ! leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:47Z [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002521 ! leukocyte differentiation relationship: positively_regulates GO:0002521 ! leukocyte differentiation created_by: pr creation_date: 2013-05-02T17:32:52Z [Term] id: GO:1902108 name: regulation of mitochondrial membrane permeability involved in apoptotic process namespace: biological_process def: "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] synonym: "regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] is_a: GO:0008637 ! apoptotic mitochondrial changes is_a: GO:0046902 ! regulation of mitochondrial membrane permeability intersection_of: GO:0046902 ! regulation of mitochondrial membrane permeability intersection_of: part_of GO:0006915 ! apoptotic process created_by: pr creation_date: 2013-05-03T12:09:35Z [Term] id: GO:1902109 name: negative regulation of mitochondrial membrane permeability involved in apoptotic process namespace: biological_process def: "Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] synonym: "mitochondrial membrane impermeability involved in apoptosis" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in apoptotic cell death" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in apoptotic process" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in apoptotic program" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in apoptotic programmed cell death" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in programmed cell death by apoptosis" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeability involved in type I programmed cell death" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in apoptotic process" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane impermeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] is_a: GO:0035795 ! negative regulation of mitochondrial membrane permeability is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process intersection_of: GO:0035795 ! negative regulation of mitochondrial membrane permeability intersection_of: part_of GO:0006915 ! apoptotic process created_by: pr creation_date: 2013-05-03T12:11:53Z [Term] id: GO:1902110 name: positive regulation of mitochondrial membrane permeability involved in apoptotic process namespace: biological_process def: "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] comment: Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process. synonym: "mitochondrial membrane permeability transition involved in apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in apoptotic process" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in apoptotic process" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in apoptotic process" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process is_a: GO:1902686 ! mitochondrial outer membrane permeabilization involved in programmed cell death intersection_of: GO:0035794 ! positive regulation of mitochondrial membrane permeability intersection_of: part_of GO:0006915 ! apoptotic process created_by: pr creation_date: 2013-05-03T12:13:56Z [Term] id: GO:1902111 name: response to diethyl maleate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2013-05-08T16:00:35Z [Term] id: GO:1902112 name: cellular response to diethyl maleate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902111 ! response to diethyl maleate created_by: mah creation_date: 2013-05-08T16:00:40Z [Term] id: GO:1902113 name: nucleotide phosphorylation involved in DNA repair namespace: biological_process def: "Any nucleotide phosphorylation that is involved in DNA repair." [GOC:TermGenie, PMID:11729194] is_a: GO:0046939 ! nucleotide phosphorylation intersection_of: GO:0046939 ! nucleotide phosphorylation intersection_of: part_of GO:0006281 ! DNA repair relationship: part_of GO:0006281 ! DNA repair created_by: al creation_date: 2013-05-13T08:56:02Z [Term] id: GO:1902114 name: D-valine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-valine." [GOC:TermGenie, PMID:23085840] synonym: "D-valine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006573 ! valine metabolic process is_a: GO:0046416 ! D-amino acid metabolic process created_by: al creation_date: 2013-05-13T23:27:23Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070925 ! organelle assembly relationship: regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070925 ! organelle assembly relationship: negatively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070925 ! organelle assembly relationship: positively_regulates GO:0070925 ! organelle assembly created_by: pr creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902118 name: calcidiol binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcidiol." [GOC:bf, GOC:TermGenie, PMID:11799400] synonym: "25(OH)D3 binding" EXACT [CHEBI:17933] synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933] synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933] synonym: "25OHD3 binding" EXACT [PMID:11799400] synonym: "calcifediol binding" EXACT [CHEBI:17933] is_a: GO:0008144 ! drug binding is_a: GO:1902271 ! D3 vitamins binding created_by: bf creation_date: 2013-05-15T14:55:58Z [Term] id: GO:1902119 name: regulation of meiotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] synonym: "regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0040020 ! regulation of meiotic nuclear division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051232 ! meiotic spindle elongation relationship: regulates GO:0051232 ! meiotic spindle elongation created_by: al creation_date: 2013-05-15T15:15:48Z [Term] id: GO:1902120 name: negative regulation of meiotic spindle elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] synonym: "down regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic spindle elongation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic spindle elongation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle elongation during meiosis" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] is_a: GO:0045835 ! negative regulation of meiotic nuclear division is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:1902119 ! regulation of meiotic spindle elongation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051232 ! meiotic spindle elongation relationship: negatively_regulates GO:0051232 ! meiotic spindle elongation created_by: al creation_date: 2013-05-15T15:15:53Z [Term] id: GO:1902121 name: lithocholic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703] synonym: "LCA binding" EXACT [PMID:20371703] is_a: GO:0005496 ! steroid binding is_a: GO:0032052 ! bile acid binding created_by: bf creation_date: 2013-05-15T16:05:12Z [Term] id: GO:1902122 name: chenodeoxycholic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992] synonym: "CDCA binding" EXACT [CHEBI:16755] is_a: GO:0005496 ! steroid binding is_a: GO:0032052 ! bile acid binding created_by: bf creation_date: 2013-05-16T09:17:19Z [Term] id: GO:1902123 name: (-)-pinoresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(-)-pinoresinol breakdown" EXACT [GOC:TermGenie] synonym: "(-)-pinoresinol catabolism" EXACT [GOC:TermGenie] synonym: "(-)-pinoresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1901598 ! (-)-pinoresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:05Z [Term] id: GO:1902124 name: (+)-pinoresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms creation_date: 2013-05-21T08:49:10Z [Term] id: GO:1902125 name: (+)-pinoresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1902124 ! (+)-pinoresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:23Z [Term] id: GO:1902126 name: (+)-pinoresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-pinoresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-pinoresinol anabolism" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902124 ! (+)-pinoresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:28Z [Term] id: GO:1902127 name: (-)-lariciresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(-)-lariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms creation_date: 2013-05-21T08:49:33Z [Term] id: GO:1902128 name: (-)-lariciresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(-)-lariciresinol breakdown" EXACT [GOC:TermGenie] synonym: "(-)-lariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(-)-lariciresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1902127 ! (-)-lariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:38Z [Term] id: GO:1902129 name: (-)-lariciresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-lariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(-)-lariciresinol anabolism" EXACT [GOC:TermGenie] synonym: "(-)-lariciresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-lariciresinol formation" EXACT [GOC:TermGenie] synonym: "(-)-lariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1902127 ! (-)-lariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:44Z [Term] id: GO:1902130 name: (+)-lariciresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms creation_date: 2013-05-21T08:49:49Z [Term] id: GO:1902131 name: (+)-lariciresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1902130 ! (+)-lariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:54Z [Term] id: GO:1902132 name: (+)-lariciresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-lariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(+)-lariciresinol anabolism" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902130 ! (+)-lariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:49:59Z [Term] id: GO:1902133 name: (+)-secoisolariciresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(+)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process created_by: ms creation_date: 2013-05-21T08:50:04Z [Term] id: GO:1902134 name: (+)-secoisolariciresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(+)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-secoisolariciresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:50:09Z [Term] id: GO:1902135 name: (+)-secoisolariciresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol." [GOC:TermGenie, PubMed:15949826, PubMed:9872995] synonym: "(+)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie] synonym: "(+)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-secoisolariciresinol formation" EXACT [GOC:TermGenie] synonym: "(+)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:50:14Z [Term] id: GO:1902136 name: (-)-secoisolariciresinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0042445 ! hormone metabolic process created_by: ms creation_date: 2013-05-21T08:50:19Z [Term] id: GO:1902137 name: (-)-secoisolariciresinol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(-)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:50:24Z [Term] id: GO:1902138 name: (-)-secoisolariciresinol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol." [GOC:TermGenie, PubMed:8910615, PubMed:9872995] synonym: "(-)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process created_by: ms creation_date: 2013-05-21T08:50:29Z [Term] id: GO:1902140 name: response to inositol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: al creation_date: 2013-05-21T13:42:10Z [Term] id: GO:1902141 name: cellular response to inositol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902140 ! response to inositol created_by: al creation_date: 2013-05-21T13:42:15Z [Term] id: GO:1902145 name: regulation of response to cell cycle checkpoint signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072396 ! response to cell cycle checkpoint signaling relationship: regulates GO:0072396 ! response to cell cycle checkpoint signaling created_by: jl creation_date: 2013-05-21T15:43:40Z [Term] id: GO:1902146 name: positive regulation of response to cell cycle checkpoint signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "activation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "activation of response to cell cycle checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "activation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "activation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "activation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "activation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] synonym: "positive regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "positive regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "positive regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "positive regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "positive regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] synonym: "up regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "up regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "up regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "up regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "up regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "up regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] synonym: "up-regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "up-regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "up-regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "up-regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "up-regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] synonym: "upregulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "upregulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] synonym: "upregulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "upregulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] synonym: "upregulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] synonym: "upregulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling relationship: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling created_by: jl creation_date: 2013-05-21T15:43:45Z [Term] id: GO:1902147 name: regulation of response to cytokinesis checkpoint signaling namespace: biological_process alt_id: GO:1902149 def: "Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072399 ! response to cytokinesis checkpoint signaling relationship: regulates GO:0072399 ! response to cytokinesis checkpoint signaling created_by: jl creation_date: 2013-05-21T15:43:53Z [Term] id: GO:1902148 name: positive regulation of response to cytokinesis checkpoint signaling namespace: biological_process alt_id: GO:1902150 def: "Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of response to cytokinesis checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling is_a: GO:1902147 ! regulation of response to cytokinesis checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling relationship: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling created_by: jl creation_date: 2013-05-21T15:43:58Z [Term] id: GO:1902151 name: regulation of response to DNA integrity checkpoint signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072402 ! response to DNA integrity checkpoint signaling relationship: regulates GO:0072402 ! response to DNA integrity checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:26Z [Term] id: GO:1902152 name: positive regulation of response to DNA integrity checkpoint signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of response to DNA integrity checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling relationship: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:31Z [Term] id: GO:1902153 name: regulation of response to DNA damage checkpoint signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072423 ! response to DNA damage checkpoint signaling relationship: regulates GO:0072423 ! response to DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:39Z [Term] id: GO:1902154 name: positive regulation of response to DNA damage checkpoint signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of response to DNA damage checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902152 ! positive regulation of response to DNA integrity checkpoint signaling is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling relationship: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:44Z [Term] id: GO:1902155 name: regulation of response to G1 DNA damage checkpoint signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling relationship: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:53Z [Term] id: GO:1902156 name: positive regulation of response to G1 DNA damage checkpoint signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of response to G1 DNA damage checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling is_a: GO:1902155 ! regulation of response to G1 DNA damage checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling relationship: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:44:58Z [Term] id: GO:1902157 name: regulation of response to G2 DNA damage checkpoint signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling relationship: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:45:06Z [Term] id: GO:1902158 name: positive regulation of response to G2 DNA damage checkpoint signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "activation of response to G2 DNA damage checkpoint signaling" NARROW [GOC:TermGenie] synonym: "activation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "positive regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "positive regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "up-regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] synonym: "upregulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] synonym: "upregulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling is_a: GO:1902157 ! regulation of response to G2 DNA damage checkpoint signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling relationship: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling created_by: jl creation_date: 2013-05-21T15:45:10Z [Term] id: GO:1902159 name: regulation of cyclic nucleotide-gated ion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] synonym: "regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity relationship: regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity created_by: sl creation_date: 2013-05-21T19:24:30Z [Term] id: GO:1902160 name: negative regulation of cyclic nucleotide-gated ion channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] synonym: "down regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity relationship: negatively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity created_by: sl creation_date: 2013-05-21T19:24:35Z [Term] id: GO:1902161 name: positive regulation of cyclic nucleotide-gated ion channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] synonym: "activation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "activation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "activation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "activation of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity relationship: positively_regulates GO:0043855 ! cyclic nucleotide-gated ion channel activity created_by: sl creation_date: 2013-05-21T19:24:48Z [Term] id: GO:1902162 name: regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541] is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator relationship: regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator created_by: lb creation_date: 2013-05-22T12:39:18Z [Term] id: GO:1902163 name: negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541] synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie] is_a: GO:0043518 ! negative regulation of DNA damage response, signal transduction by p53 class mediator is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator relationship: negatively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator created_by: lb creation_date: 2013-05-22T12:39:23Z [Term] id: GO:1902164 name: positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, pubmed:17719541] synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie] synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] is_a: GO:0043517 ! positive regulation of DNA damage response, signal transduction by p53 class mediator is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator relationship: positively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator created_by: lb creation_date: 2013-05-22T12:39:29Z [Term] id: GO:1902165 name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] synonym: "regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator relationship: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator created_by: lb creation_date: 2013-05-22T12:45:10Z [Term] id: GO:1902166 name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator is_a: GO:1902230 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator relationship: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator created_by: lb creation_date: 2013-05-22T12:45:15Z [Term] id: GO:1902167 name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator is_a: GO:1902231 ! positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator relationship: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator created_by: lb creation_date: 2013-05-22T12:45:20Z [Term] id: GO:1902168 name: response to catechin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620] is_a: GO:0080184 ! response to phenylpropanoid is_a: GO:1905395 ! response to flavonoid created_by: rjd creation_date: 2013-05-22T17:35:35Z [Term] id: GO:1902169 name: cellular response to catechin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620] is_a: GO:1902168 ! response to catechin is_a: GO:1905396 ! cellular response to flavonoid is_a: GO:1905546 ! cellular response to phenylpropanoid created_by: rjd creation_date: 2013-05-22T17:35:40Z [Term] id: GO:1902170 name: cellular response to reactive nitrogen species namespace: biological_process alt_id: GO:1990106 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638] is_a: GO:1901699 ! cellular response to nitrogen compound created_by: tb creation_date: 2013-05-23T00:23:59Z [Term] id: GO:1902171 name: regulation of tocopherol cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tocopherol cyclase activity." [GOC:TermGenie, PMID:23632854] is_a: GO:0031279 ! regulation of cyclase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009976 ! tocopherol cyclase activity relationship: regulates GO:0009976 ! tocopherol cyclase activity created_by: tb creation_date: 2013-05-25T00:41:14Z [Term] id: GO:1902172 name: regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097283 ! keratinocyte apoptotic process relationship: regulates GO:0097283 ! keratinocyte apoptotic process created_by: rl creation_date: 2013-05-29T14:36:11Z [Term] id: GO:1902173 name: negative regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "down regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of keratinocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1902172 ! regulation of keratinocyte apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097283 ! keratinocyte apoptotic process relationship: negatively_regulates GO:0097283 ! keratinocyte apoptotic process created_by: rl creation_date: 2013-05-29T14:36:15Z [Term] id: GO:1902174 name: positive regulation of keratinocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] synonym: "activation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of keratinocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1902172 ! regulation of keratinocyte apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097283 ! keratinocyte apoptotic process relationship: positively_regulates GO:0097283 ! keratinocyte apoptotic process created_by: rl creation_date: 2013-05-29T14:36:21Z [Term] id: GO:1902175 name: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] synonym: "regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] is_a: GO:1903201 ! regulation of oxidative stress-induced cell death is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress relationship: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress created_by: pr creation_date: 2013-05-29T18:30:00Z [Term] id: GO:1902176 name: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress relationship: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress created_by: pr creation_date: 2013-05-29T18:30:05Z [Term] id: GO:1902177 name: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] synonym: "activation of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress relationship: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress created_by: pr creation_date: 2013-05-29T18:30:10Z [Term] id: GO:1902178 name: fibroblast growth factor receptor apoptotic signaling pathway namespace: biological_process def: "An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR)." [GOC:mtg_apoptosis, GOC:pm, GOC:pr, GOC:TermGenie, PMID:17561467] synonym: "FGF receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "FGF receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "FGF receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "FGFR signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] synonym: "FGFR signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "FGFR signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "FGFR signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "FGFR signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "FGFR signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "FGFR signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "FGFR signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic process" EXACT [GOC:pm] synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "fibroblast growth factor receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] synonym: "fibroblast growth factor receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway is_a: GO:0097191 ! extrinsic apoptotic signaling pathway created_by: pm creation_date: 2013-05-30T13:59:57Z [Term] id: GO:1902179 name: verruculogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] synonym: "verruculogen metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0035834 ! indole alkaloid metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di creation_date: 2013-05-30T17:44:25Z [Term] id: GO:1902180 name: verruculogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] synonym: "verruculogen breakdown" EXACT [GOC:TermGenie] synonym: "verruculogen catabolism" EXACT [GOC:TermGenie] synonym: "verruculogen degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1902179 ! verruculogen metabolic process created_by: di creation_date: 2013-05-30T17:44:30Z [Term] id: GO:1902181 name: verruculogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] synonym: "verruculogen anabolism" EXACT [GOC:TermGenie] synonym: "verruculogen biosynthesis" EXACT [GOC:TermGenie] synonym: "verruculogen formation" EXACT [GOC:TermGenie] synonym: "verruculogen synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902179 ! verruculogen metabolic process created_by: di creation_date: 2013-05-30T17:44:35Z [Term] id: GO:1902182 name: shoot apical meristem development namespace: biological_process def: "The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure." [GOC:TermGenie, PMID:21496644] synonym: "primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "promeristem development" BROAD [GOC:TermGenie] synonym: "SAM development" EXACT [GOC:TermGenie] is_a: GO:0048507 ! meristem development created_by: tb creation_date: 2013-05-30T23:13:21Z [Term] id: GO:1902183 name: regulation of shoot apical meristem development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] synonym: "regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "regulation of SAM development" EXACT [GOC:TermGenie] is_a: GO:0048509 ! regulation of meristem development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902182 ! shoot apical meristem development relationship: regulates GO:1902182 ! shoot apical meristem development created_by: tb creation_date: 2013-05-31T16:33:55Z [Term] id: GO:1902184 name: negative regulation of shoot apical meristem development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] synonym: "down regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "down regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "down regulation of SAM development" EXACT [GOC:TermGenie] synonym: "down regulation of shoot apical meristem development" EXACT [GOC:TermGenie] synonym: "down-regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "down-regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "down-regulation of SAM development" EXACT [GOC:TermGenie] synonym: "down-regulation of shoot apical meristem development" EXACT [GOC:TermGenie] synonym: "downregulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "downregulation of promeristem development" BROAD [GOC:TermGenie] synonym: "downregulation of SAM development" EXACT [GOC:TermGenie] synonym: "downregulation of shoot apical meristem development" EXACT [GOC:TermGenie] synonym: "inhibition of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "inhibition of promeristem development" BROAD [GOC:TermGenie] synonym: "inhibition of SAM development" EXACT [GOC:TermGenie] synonym: "inhibition of shoot apical meristem development" NARROW [GOC:TermGenie] synonym: "negative regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "negative regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "negative regulation of SAM development" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1902183 ! regulation of shoot apical meristem development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902182 ! shoot apical meristem development relationship: negatively_regulates GO:1902182 ! shoot apical meristem development created_by: tb creation_date: 2013-05-31T16:34:00Z [Term] id: GO:1902185 name: positive regulation of shoot apical meristem development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] synonym: "activation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "activation of promeristem development" BROAD [GOC:TermGenie] synonym: "activation of SAM development" EXACT [GOC:TermGenie] synonym: "activation of shoot apical meristem development" NARROW [GOC:TermGenie] synonym: "positive regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "positive regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "positive regulation of SAM development" EXACT [GOC:TermGenie] synonym: "up regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "up regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "up regulation of SAM development" EXACT [GOC:TermGenie] synonym: "up regulation of shoot apical meristem development" EXACT [GOC:TermGenie] synonym: "up-regulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "up-regulation of promeristem development" BROAD [GOC:TermGenie] synonym: "up-regulation of SAM development" EXACT [GOC:TermGenie] synonym: "up-regulation of shoot apical meristem development" EXACT [GOC:TermGenie] synonym: "upregulation of primary shoot meristem development" RELATED [GOC:TermGenie] synonym: "upregulation of promeristem development" BROAD [GOC:TermGenie] synonym: "upregulation of SAM development" EXACT [GOC:TermGenie] synonym: "upregulation of shoot apical meristem development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1902183 ! regulation of shoot apical meristem development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902182 ! shoot apical meristem development relationship: positively_regulates GO:1902182 ! shoot apical meristem development created_by: tb creation_date: 2013-05-31T16:34:05Z [Term] id: GO:1902186 name: regulation of viral release from host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167] synonym: "regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "regulation of viral exit" EXACT [GOC:TermGenie] synonym: "regulation of viral release" EXACT [GOC:TermGenie] synonym: "regulation of viral shedding" EXACT [GOC:TermGenie] is_a: GO:0040012 ! regulation of locomotion is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019076 ! viral release from host cell relationship: regulates GO:0019076 ! viral release from host cell created_by: ss creation_date: 2013-06-04T03:54:03Z [Term] id: GO:1902187 name: negative regulation of viral release from host cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167] synonym: "down regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "down regulation of viral exit" EXACT [GOC:TermGenie] synonym: "down regulation of viral release" EXACT [GOC:TermGenie] synonym: "down regulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "down regulation of viral shedding" EXACT [GOC:TermGenie] synonym: "down-regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "down-regulation of viral exit" EXACT [GOC:TermGenie] synonym: "down-regulation of viral release" EXACT [GOC:TermGenie] synonym: "down-regulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "down-regulation of viral shedding" EXACT [GOC:TermGenie] synonym: "downregulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "downregulation of viral exit" EXACT [GOC:TermGenie] synonym: "downregulation of viral release" EXACT [GOC:TermGenie] synonym: "downregulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "downregulation of viral shedding" EXACT [GOC:TermGenie] synonym: "inhibition of release of virus from host" EXACT [GOC:TermGenie] synonym: "inhibition of viral exit" EXACT [GOC:TermGenie] synonym: "inhibition of viral release" EXACT [GOC:TermGenie] synonym: "inhibition of viral release from host cell" NARROW [GOC:TermGenie] synonym: "inhibition of viral shedding" EXACT [GOC:TermGenie] synonym: "negative regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "negative regulation of viral exit" EXACT [GOC:TermGenie] synonym: "negative regulation of viral release" EXACT [GOC:TermGenie] synonym: "negative regulation of viral shedding" EXACT [GOC:TermGenie] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:1902186 ! regulation of viral release from host cell is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019076 ! viral release from host cell relationship: negatively_regulates GO:0019076 ! viral release from host cell created_by: ss creation_date: 2013-06-04T03:54:08Z [Term] id: GO:1902188 name: positive regulation of viral release from host cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167] synonym: "activation of release of virus from host" EXACT [GOC:TermGenie] synonym: "activation of viral exit" EXACT [GOC:TermGenie] synonym: "activation of viral release" EXACT [GOC:TermGenie] synonym: "activation of viral release from host cell" NARROW [GOC:TermGenie] synonym: "activation of viral shedding" EXACT [GOC:TermGenie] synonym: "positive regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "positive regulation of viral exit" EXACT [GOC:TermGenie] synonym: "positive regulation of viral release" EXACT [GOC:TermGenie] synonym: "positive regulation of viral shedding" EXACT [GOC:TermGenie] synonym: "up regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "up regulation of viral exit" EXACT [GOC:TermGenie] synonym: "up regulation of viral release" EXACT [GOC:TermGenie] synonym: "up regulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "up regulation of viral shedding" EXACT [GOC:TermGenie] synonym: "up-regulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "up-regulation of viral exit" EXACT [GOC:TermGenie] synonym: "up-regulation of viral release" EXACT [GOC:TermGenie] synonym: "up-regulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "up-regulation of viral shedding" EXACT [GOC:TermGenie] synonym: "upregulation of release of virus from host" EXACT [GOC:TermGenie] synonym: "upregulation of viral exit" EXACT [GOC:TermGenie] synonym: "upregulation of viral release" EXACT [GOC:TermGenie] synonym: "upregulation of viral release from host cell" EXACT [GOC:TermGenie] synonym: "upregulation of viral shedding" EXACT [GOC:TermGenie] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:1902186 ! regulation of viral release from host cell is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019076 ! viral release from host cell relationship: positively_regulates GO:0019076 ! viral release from host cell created_by: ss creation_date: 2013-06-04T03:54:14Z [Term] id: GO:1902189 name: 2-methylbutanoyl-CoA(4-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbutanoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: ms creation_date: 2013-06-06T09:40:14Z [Term] id: GO:1902190 name: 2-methylbutanoyl-CoA(4-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbutanoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] synonym: "2-methylbutanoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] synonym: "2-methylbutanoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] is_a: GO:0036115 ! fatty-acyl-CoA catabolic process is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:40:20Z [Term] id: GO:1902191 name: 2-methylbutanoyl-CoA(4-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbutanoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] synonym: "2-methylbutanoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] synonym: "2-methylbutanoyl-CoA(4-) formation" EXACT [GOC:TermGenie] synonym: "2-methylbutanoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:40:25Z [Term] id: GO:1902192 name: 2-methylbut-2-enoyl-CoA(4-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: ms creation_date: 2013-06-06T09:40:30Z [Term] id: GO:1902193 name: 2-methylbut-2-enoyl-CoA(4-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] synonym: "2-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] synonym: "2-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] is_a: GO:0036115 ! fatty-acyl-CoA catabolic process is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:40:41Z [Term] id: GO:1902194 name: 2-methylbut-2-enoyl-CoA(4-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pubmed:15574432] synonym: "2-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] synonym: "2-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] synonym: "2-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie] synonym: "2-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:40:46Z [Term] id: GO:1902195 name: isovaleryl-CoA(4-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "isovaleryl-CoA(4-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: ms creation_date: 2013-06-06T09:55:55Z [Term] id: GO:1902196 name: isovaleryl-CoA(4-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "isovaleryl-CoA(4-) breakdown" EXACT [GOC:TermGenie] synonym: "isovaleryl-CoA(4-) catabolism" EXACT [GOC:TermGenie] synonym: "isovaleryl-CoA(4-) degradation" EXACT [GOC:TermGenie] is_a: GO:0036115 ! fatty-acyl-CoA catabolic process is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:56:00Z [Term] id: GO:1902197 name: isovaleryl-CoA(4-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "isovaleryl-CoA(4-) anabolism" EXACT [GOC:TermGenie] synonym: "isovaleryl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] synonym: "isovaleryl-CoA(4-) formation" EXACT [GOC:TermGenie] synonym: "isovaleryl-CoA(4-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:56:05Z [Term] id: GO:1902198 name: 3-methylbut-2-enoyl-CoA(4-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "3-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: ms creation_date: 2013-06-06T09:56:11Z [Term] id: GO:1902199 name: 3-methylbut-2-enoyl-CoA(4-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "3-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] synonym: "3-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] synonym: "3-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] is_a: GO:0036115 ! fatty-acyl-CoA catabolic process is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:56:16Z [Term] id: GO:1902200 name: 3-methylbut-2-enoyl-CoA(4-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] synonym: "3-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] synonym: "3-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] synonym: "3-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie] synonym: "3-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process created_by: ms creation_date: 2013-06-06T09:56:21Z [Term] id: GO:1902201 name: negative regulation of bacterial-type flagellum-dependent cell motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "down regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] synonym: "down regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] synonym: "inhibition of bacterial-type flagellar cell motility" NARROW [GOC:TermGenie] synonym: "inhibition of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] synonym: "negative regulation of bacterial-type flagellar cell motility" RELATED [] synonym: "negative regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility relationship: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility created_by: jl creation_date: 2013-06-06T14:58:41Z [Term] id: GO:1902202 name: regulation of hepatocyte growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] synonym: "regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of Met signaling pathway" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway relationship: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway created_by: lb creation_date: 2013-06-10T13:20:45Z [Term] id: GO:1902203 name: negative regulation of hepatocyte growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] synonym: "down regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "downregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of Met signaling pathway" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway relationship: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway created_by: lb creation_date: 2013-06-10T13:20:51Z [Term] id: GO:1902204 name: positive regulation of hepatocyte growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] synonym: "activation of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "activation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of Met signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of Met signaling pathway" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway relationship: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway created_by: lb creation_date: 2013-06-10T13:20:56Z [Term] id: GO:1902205 name: regulation of interleukin-2-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] synonym: "regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038110 ! interleukin-2-mediated signaling pathway relationship: regulates GO:0038110 ! interleukin-2-mediated signaling pathway created_by: lb creation_date: 2013-06-11T07:34:39Z [Term] id: GO:1902206 name: negative regulation of interleukin-2-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] synonym: "down regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway relationship: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway created_by: lb creation_date: 2013-06-11T07:34:45Z [Term] id: GO:1902207 name: positive regulation of interleukin-2-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] synonym: "activation of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway relationship: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway created_by: lb creation_date: 2013-06-11T07:34:50Z [Term] id: GO:1902208 name: regulation of bacterial-type flagellum assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] synonym: "regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044780 ! bacterial-type flagellum assembly relationship: regulates GO:0044780 ! bacterial-type flagellum assembly created_by: jl creation_date: 2013-06-11T14:20:19Z [Term] id: GO:1902209 name: negative regulation of bacterial-type flagellum assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] synonym: "down regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "down regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] synonym: "downregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "downregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] synonym: "inhibition of bacterial flagellum assembly" NARROW [GOC:TermGenie] synonym: "inhibition of bacterial-type flagellum assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly relationship: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly created_by: jl creation_date: 2013-06-11T14:20:24Z [Term] id: GO:1902210 name: positive regulation of bacterial-type flagellum assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] synonym: "activation of bacterial flagellum assembly" NARROW [GOC:TermGenie] synonym: "activation of bacterial-type flagellum assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "up regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "up regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] synonym: "upregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] synonym: "upregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044780 ! bacterial-type flagellum assembly relationship: positively_regulates GO:0044780 ! bacterial-type flagellum assembly created_by: jl creation_date: 2013-06-11T14:20:30Z [Term] id: GO:1902211 name: regulation of prolactin signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038161 ! prolactin signaling pathway relationship: regulates GO:0038161 ! prolactin signaling pathway created_by: lb creation_date: 2013-06-12T10:10:07Z [Term] id: GO:1902212 name: negative regulation of prolactin signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038161 ! prolactin signaling pathway relationship: negatively_regulates GO:0038161 ! prolactin signaling pathway created_by: lb creation_date: 2013-06-12T10:10:12Z [Term] id: GO:1902213 name: positive regulation of prolactin signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038161 ! prolactin signaling pathway relationship: positively_regulates GO:0038161 ! prolactin signaling pathway created_by: lb creation_date: 2013-06-12T10:10:18Z [Term] id: GO:1902214 name: regulation of interleukin-4-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] synonym: "regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035771 ! interleukin-4-mediated signaling pathway relationship: regulates GO:0035771 ! interleukin-4-mediated signaling pathway created_by: lb creation_date: 2013-06-12T12:53:09Z [Term] id: GO:1902215 name: negative regulation of interleukin-4-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] synonym: "down regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway relationship: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway created_by: lb creation_date: 2013-06-12T12:53:14Z [Term] id: GO:1902216 name: positive regulation of interleukin-4-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] synonym: "activation of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway relationship: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway created_by: lb creation_date: 2013-06-12T12:53:20Z [Term] id: GO:1902217 name: erythrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033028 ! myeloid cell apoptotic process created_by: rl creation_date: 2013-06-13T10:02:29Z [Term] id: GO:1902218 name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] is_a: GO:0106049 ! regulation of cellular response to osmotic stress is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress relationship: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress created_by: rl creation_date: 2013-06-13T10:19:07Z [Term] id: GO:1902219 name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie] is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress relationship: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress created_by: rl creation_date: 2013-06-13T10:19:12Z [Term] id: GO:1902220 name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress relationship: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress created_by: rl creation_date: 2013-06-13T10:19:18Z [Term] id: GO:1902221 name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: pr creation_date: 2013-06-13T10:37:38Z [Term] id: GO:1902222 name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown" EXACT [GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism" EXACT [GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:1901606 ! alpha-amino acid catabolic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process created_by: pr creation_date: 2013-06-13T10:37:43Z [Term] id: GO:1902223 name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism" EXACT [GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation" EXACT [GOC:TermGenie] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:1901607 ! alpha-amino acid biosynthetic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process created_by: pr creation_date: 2013-06-13T10:37:49Z [Term] id: GO:1902224 name: ketone body metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie] synonym: "ketone body metabolism" EXACT [GOC:TermGenie] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0017144 ! drug metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process created_by: pr creation_date: 2013-06-13T10:37:54Z [Term] id: GO:1902225 name: negative regulation of acrosome reaction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction." [GOC:TermGenie, PMID:23430248] synonym: "down regulation of acrosome reaction" EXACT [GOC:TermGenie] synonym: "down-regulation of acrosome reaction" EXACT [GOC:TermGenie] synonym: "downregulation of acrosome reaction" EXACT [GOC:TermGenie] synonym: "inhibition of acrosome reaction" NARROW [GOC:TermGenie] is_a: GO:0060046 ! regulation of acrosome reaction is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007340 ! acrosome reaction relationship: negatively_regulates GO:0007340 ! acrosome reaction created_by: Anne.Estreicher creation_date: 2013-06-13T14:17:11Z [Term] id: GO:1902226 name: regulation of macrophage colony-stimulating factor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] synonym: "regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway relationship: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway created_by: lb creation_date: 2013-06-14T06:28:42Z [Term] id: GO:1902227 name: negative regulation of macrophage colony-stimulating factor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] synonym: "down regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of M-CSF signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway is_a: GO:1903973 ! negative regulation of cellular response to macrophage colony-stimulating factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway relationship: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway created_by: lb creation_date: 2013-06-14T06:28:54Z [Term] id: GO:1902228 name: positive regulation of macrophage colony-stimulating factor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] synonym: "activation of M-CSF signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway is_a: GO:1903974 ! positive regulation of cellular response to macrophage colony-stimulating factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway relationship: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway created_by: lb creation_date: 2013-06-14T06:29:00Z [Term] id: GO:1902229 name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] synonym: "regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:2001020 ! regulation of response to DNA damage stimulus is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage relationship: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage created_by: rl creation_date: 2013-06-14T09:39:52Z [Term] id: GO:1902230 name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] synonym: "down regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] synonym: "downregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] synonym: "inhibition of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage relationship: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage created_by: rl creation_date: 2013-06-14T09:39:58Z [Term] id: GO:1902231 name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] synonym: "activation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] synonym: "upregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage relationship: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage created_by: rl creation_date: 2013-06-14T09:40:03Z [Term] id: GO:1902232 name: regulation of positive thymic T cell selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] synonym: "regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] is_a: GO:0033081 ! regulation of T cell differentiation in thymus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045059 ! positive thymic T cell selection relationship: regulates GO:0045059 ! positive thymic T cell selection created_by: lb creation_date: 2013-06-14T11:19:09Z [Term] id: GO:1902233 name: negative regulation of positive thymic T cell selection namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] synonym: "down regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "down regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "down regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "down regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "down-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "down-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "down-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "down-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "downregulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "downregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "downregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "downregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "inhibition of positive thymic T cell selection" NARROW [GOC:TermGenie] synonym: "inhibition of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie] synonym: "inhibition of positive thymic T-cell selection" NARROW [GOC:TermGenie] synonym: "inhibition of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie] synonym: "negative regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "negative regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "negative regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus is_a: GO:1902232 ! regulation of positive thymic T cell selection intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045059 ! positive thymic T cell selection relationship: negatively_regulates GO:0045059 ! positive thymic T cell selection created_by: lb creation_date: 2013-06-14T11:19:15Z [Term] id: GO:1902234 name: positive regulation of positive thymic T cell selection namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] synonym: "activation of positive thymic T cell selection" NARROW [GOC:TermGenie] synonym: "activation of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie] synonym: "activation of positive thymic T-cell selection" NARROW [GOC:TermGenie] synonym: "activation of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie] synonym: "positive regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "positive regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "positive regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "up regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "up regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "up regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "up regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "up-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "up-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "up-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "up-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] synonym: "upregulation of positive thymic T cell selection" EXACT [GOC:TermGenie] synonym: "upregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] synonym: "upregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] synonym: "upregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus is_a: GO:1902232 ! regulation of positive thymic T cell selection intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045059 ! positive thymic T cell selection relationship: positively_regulates GO:0045059 ! positive thymic T cell selection created_by: lb creation_date: 2013-06-14T11:19:20Z [Term] id: GO:1902235 name: regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] synonym: "regulation of apoptosis in response to endoplasmic reticulum stress" BROAD [GOC:TermGenie] synonym: "regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress created_by: rl creation_date: 2013-06-18T15:19:37Z [Term] id: GO:1902236 name: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] synonym: "down regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "down regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosis in response to ER stress" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis triggered by ER stress" NARROW [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of ER stress-induced apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress created_by: rl creation_date: 2013-06-18T15:19:43Z [Term] id: GO:1902237 name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] synonym: "activation of apoptosis in response to ER stress" NARROW [GOC:TermGenie] synonym: "activation of apoptosis triggered by ER stress" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie] synonym: "activation of ER stress-induced apoptosis" NARROW [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "up regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress created_by: rl creation_date: 2013-06-18T15:19:49Z [Term] id: GO:1902238 name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator relationship: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator created_by: pr creation_date: 2013-06-19T14:00:34Z [Term] id: GO:1902239 name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie] is_a: GO:1902219 ! negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator relationship: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator created_by: pr creation_date: 2013-06-19T14:00:39Z [Term] id: GO:1902240 name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] is_a: GO:1902220 ! positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator relationship: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator created_by: pr creation_date: 2013-06-19T14:00:44Z [Term] id: GO:1902241 name: copal-8-ol diphosphate(3-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] synonym: "copal-8-ol diphosphate(3-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0016101 ! diterpenoid metabolic process created_by: ms creation_date: 2013-06-20T09:09:27Z [Term] id: GO:1902242 name: copal-8-ol diphosphate(3-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] synonym: "copal-8-ol diphosphate(3-) breakdown" EXACT [GOC:TermGenie] synonym: "copal-8-ol diphosphate(3-) catabolism" EXACT [GOC:TermGenie] synonym: "copal-8-ol diphosphate(3-) degradation" EXACT [GOC:TermGenie] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process created_by: ms creation_date: 2013-06-20T09:09:33Z [Term] id: GO:1902243 name: copal-8-ol diphosphate(3-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] synonym: "copal-8-ol diphosphate(3-) anabolism" EXACT [GOC:TermGenie] synonym: "copal-8-ol diphosphate(3-) biosynthesis" EXACT [GOC:TermGenie] synonym: "copal-8-ol diphosphate(3-) formation" EXACT [GOC:TermGenie] synonym: "copal-8-ol diphosphate(3-) synthesis" EXACT [GOC:TermGenie] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process created_by: ms creation_date: 2013-06-20T09:09:38Z [Term] id: GO:1902244 name: cis-abienol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cis-abienol." [GOC:TermGenie, pmid:22672125] synonym: "cis-abienol metabolism" EXACT [GOC:TermGenie] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: ms creation_date: 2013-06-20T09:09:51Z [Term] id: GO:1902245 name: cis-abienol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cis-abienol." [GOC:TermGenie, pmid:22672125] synonym: "cis-abienol breakdown" EXACT [GOC:TermGenie] synonym: "cis-abienol catabolism" EXACT [GOC:TermGenie] synonym: "cis-abienol degradation" EXACT [GOC:TermGenie] is_a: GO:0016103 ! diterpenoid catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1902244 ! cis-abienol metabolic process created_by: ms creation_date: 2013-06-20T09:09:57Z [Term] id: GO:1902246 name: cis-abienol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cis-abienol." [GOC:TermGenie, pmid:22672125] synonym: "cis-abienol anabolism" EXACT [GOC:TermGenie] synonym: "cis-abienol biosynthesis" EXACT [GOC:TermGenie] synonym: "cis-abienol formation" EXACT [GOC:TermGenie] synonym: "cis-abienol synthesis" EXACT [GOC:TermGenie] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:1902244 ! cis-abienol metabolic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process created_by: ms creation_date: 2013-06-20T09:10:02Z [Term] id: GO:1902247 name: geranylgeranyl diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate." [GOC:TermGenie, pmid:22672125] synonym: "geranylgeranyl diphosphate breakdown" EXACT [GOC:TermGenie] synonym: "geranylgeranyl diphosphate catabolism" EXACT [GOC:TermGenie] synonym: "geranylgeranyl diphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0016115 ! terpenoid catabolic process is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process created_by: ms creation_date: 2013-06-20T09:10:09Z [Term] id: GO:1902248 name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-O-phosphono-alpha-D-ribofuranosyl diphosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] synonym: "5-phosphoribose 1-diphosphate binding" EXACT [] synonym: "phosphoribosylpyrophosphate binding" EXACT [GOC:al] is_a: GO:0043168 ! anion binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: mah creation_date: 2013-06-20T16:20:29Z [Term] id: GO:1902249 name: IMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with IMP, inosine monophosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] is_a: GO:0032555 ! purine ribonucleotide binding is_a: GO:0043168 ! anion binding created_by: mah creation_date: 2013-06-20T16:20:35Z [Term] id: GO:1902250 name: regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902217 ! erythrocyte apoptotic process relationship: regulates GO:1902217 ! erythrocyte apoptotic process created_by: rl creation_date: 2013-06-20T19:30:53Z [Term] id: GO:1902251 name: negative regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902217 ! erythrocyte apoptotic process relationship: negatively_regulates GO:1902217 ! erythrocyte apoptotic process created_by: rl creation_date: 2013-06-20T19:30:59Z [Term] id: GO:1902252 name: positive regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902217 ! erythrocyte apoptotic process relationship: positively_regulates GO:1902217 ! erythrocyte apoptotic process created_by: rl creation_date: 2013-06-20T19:31:04Z [Term] id: GO:1902253 name: regulation of intrinsic apoptotic signaling pathway by p53 class mediator namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] synonym: "regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator relationship: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator created_by: rl creation_date: 2013-06-20T19:41:38Z [Term] id: GO:1902254 name: negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] synonym: "down regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie] synonym: "inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator relationship: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator created_by: rl creation_date: 2013-06-20T19:41:43Z [Term] id: GO:1902255 name: positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] synonym: "activation of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie] synonym: "activation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] synonym: "upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator relationship: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator created_by: rl creation_date: 2013-06-20T19:41:54Z [Term] id: GO:1902256 name: regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis relationship: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis created_by: dph creation_date: 2013-06-24T19:12:24Z [Term] id: GO:1902257 name: negative regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis relationship: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis created_by: dph creation_date: 2013-06-24T19:12:30Z [Term] id: GO:1902258 name: positive regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis relationship: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis created_by: dph creation_date: 2013-06-24T19:12:42Z [Term] id: GO:1902259 name: regulation of delayed rectifier potassium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204] is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005251 ! delayed rectifier potassium channel activity relationship: regulates GO:0005251 ! delayed rectifier potassium channel activity created_by: rl creation_date: 2013-06-25T12:16:19Z [Term] id: GO:1902260 name: negative regulation of delayed rectifier potassium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204] synonym: "down regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie] is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005251 ! delayed rectifier potassium channel activity relationship: negatively_regulates GO:0005251 ! delayed rectifier potassium channel activity created_by: rl creation_date: 2013-06-25T12:16:24Z [Term] id: GO:1902261 name: positive regulation of delayed rectifier potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204] synonym: "activation of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005251 ! delayed rectifier potassium channel activity relationship: positively_regulates GO:0005251 ! delayed rectifier potassium channel activity created_by: rl creation_date: 2013-06-25T12:16:30Z [Term] id: GO:1902262 name: apoptotic process involved in blood vessel morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048514 ! blood vessel morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2013-06-25T16:16:00Z [Term] id: GO:1902263 name: apoptotic process involved in embryonic digit morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in embryonic digit morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:15967824] synonym: "apoptosis involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in embryonic digit morphogenesis" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0042733 ! embryonic digit morphogenesis relationship: part_of GO:0042733 ! embryonic digit morphogenesis created_by: dph creation_date: 2013-06-25T16:19:22Z [Term] id: GO:1902265 name: abscisic acid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell." [GOC:TermGenie, PMID:23252460] synonym: "2-cis-abscisate homeostasis" RELATED [] synonym: "ABA homeostasis" RELATED [] is_a: GO:0055081 ! anion homeostasis is_a: GO:0055088 ! lipid homeostasis created_by: tb creation_date: 2013-06-27T21:05:30Z [Term] id: GO:1902266 name: cellular abscisic acid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of abscisic acid at the level of the cell." [GOC:TermGenie, PMID:23252460] synonym: "cellular 2-cis-abscisate homeostasis" EXACT [] synonym: "cellular ABA homeostasis" RELATED [] is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:1902265 ! abscisic acid homeostasis created_by: tb creation_date: 2013-06-27T21:05:36Z [Term] id: GO:1902267 name: regulation of polyamine transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902047 ! polyamine transmembrane transport relationship: regulates GO:1902047 ! polyamine transmembrane transport created_by: mcc creation_date: 2013-06-28T21:34:36Z [Term] id: GO:1902268 name: negative regulation of polyamine transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] synonym: "down regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of polyamine transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:1902267 ! regulation of polyamine transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902047 ! polyamine transmembrane transport relationship: negatively_regulates GO:1902047 ! polyamine transmembrane transport created_by: mcc creation_date: 2013-06-28T21:34:42Z [Term] id: GO:1902269 name: positive regulation of polyamine transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] synonym: "activation of polyamine transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:1902267 ! regulation of polyamine transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902047 ! polyamine transmembrane transport relationship: positively_regulates GO:1902047 ! polyamine transmembrane transport created_by: mcc creation_date: 2013-06-28T21:34:47Z [Term] id: GO:1902270 name: (R)-carnitine transmembrane transport namespace: biological_process def: "The process in which (R)-carnitine is transported across a membrane." [GOC:TermGenie, PMID:23755272] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:1900749 ! (R)-carnitine transport is_a: GO:1902603 ! carnitine transmembrane transport created_by: mcc creation_date: 2013-06-28T21:57:39Z [Term] id: GO:1902271 name: D3 vitamins binding namespace: molecular_function def: "Interacting selectively and non-covalently with D3 vitamins." [GOC:bf, GOC:TermGenie, PMID:9127467] is_a: GO:0005499 ! vitamin D binding created_by: bf creation_date: 2013-07-01T12:54:37Z [Term] id: GO:1902272 name: regulation of (R)-carnitine transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport created_by: mcc creation_date: 2013-07-01T13:13:11Z [Term] id: GO:1902273 name: negative regulation of (R)-carnitine transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] synonym: "down regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport created_by: mcc creation_date: 2013-07-01T13:13:17Z [Term] id: GO:1902274 name: positive regulation of (R)-carnitine transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] synonym: "activation of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport created_by: mcc creation_date: 2013-07-01T13:13:22Z [Term] id: GO:1902275 name: regulation of chromatin organization namespace: biological_process alt_id: GO:1903308 def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006325 ! chromatin organization relationship: regulates GO:0006325 ! chromatin organization created_by: bf creation_date: 2013-07-01T13:21:52Z [Term] id: GO:1902276 name: regulation of pancreatic amylase secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0090186 ! regulation of pancreatic juice secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036395 ! pancreatic amylase secretion relationship: regulates GO:0036395 ! pancreatic amylase secretion created_by: bf creation_date: 2013-07-03T12:15:20Z [Term] id: GO:1902277 name: negative regulation of pancreatic amylase secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie] synonym: "down regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] synonym: "inhibition of pancreatic amylase secretion" NARROW [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090188 ! negative regulation of pancreatic juice secretion is_a: GO:1902276 ! regulation of pancreatic amylase secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036395 ! pancreatic amylase secretion relationship: negatively_regulates GO:0036395 ! pancreatic amylase secretion created_by: bf creation_date: 2013-07-03T12:15:26Z [Term] id: GO:1902278 name: positive regulation of pancreatic amylase secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687] synonym: "activation of pancreatic amylase secretion" NARROW [GOC:TermGenie] synonym: "up regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090187 ! positive regulation of pancreatic juice secretion is_a: GO:1902276 ! regulation of pancreatic amylase secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036395 ! pancreatic amylase secretion relationship: positively_regulates GO:0036395 ! pancreatic amylase secretion created_by: bf creation_date: 2013-07-03T12:15:31Z [Term] id: GO:1902279 name: positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway namespace: biological_process def: "A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687] synonym: "activation of pancreatic amylase secretion by cholecystokinin signaling pathway" NARROW [GOC:TermGenie] synonym: "CCK-induced amylase release in pancreatic cell" EXACT [PMID:19028687] synonym: "CCK-mediated pancreatic amylase secretion" EXACT [PMID:19028687] synonym: "CCK-stimulated pancreatic amylase release" EXACT [PMID:19028687] synonym: "cholecystokinin-mediated pancreatic amylase secretion" EXACT [PMID:19028687] synonym: "up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0038188 ! cholecystokinin signaling pathway is_a: GO:1902278 ! positive regulation of pancreatic amylase secretion intersection_of: GO:0038188 ! cholecystokinin signaling pathway intersection_of: positively_regulates GO:0036395 ! pancreatic amylase secretion created_by: bf creation_date: 2013-07-03T16:02:40Z [Term] id: GO:1902280 name: regulation of RNA helicase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653] synonym: "regulation of ATP-dependent RNA helicase activity" EXACT [] is_a: GO:0051095 ! regulation of helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003724 ! RNA helicase activity relationship: regulates GO:0003724 ! RNA helicase activity created_by: rb creation_date: 2013-07-03T18:05:19Z [Term] id: GO:1902281 name: negative regulation of RNA helicase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653] synonym: "down regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ATP-dependent RNA helicase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP-dependent RNA helicase activity" EXACT [] is_a: GO:0051097 ! negative regulation of helicase activity is_a: GO:1902280 ! regulation of RNA helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003724 ! RNA helicase activity relationship: negatively_regulates GO:0003724 ! RNA helicase activity created_by: rb creation_date: 2013-07-03T18:05:25Z [Term] id: GO:1902282 name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244] synonym: "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization relationship: part_of GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential created_by: rl creation_date: 2013-07-05T20:12:22Z [Term] id: GO:1902283 name: negative regulation of primary amine oxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity." [GOC:TermGenie, PMID:23349812] synonym: "down regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] synonym: "down regulation of primary amine oxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] synonym: "down-regulation of primary amine oxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] synonym: "downregulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] synonym: "downregulation of primary amine oxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] synonym: "inhibition of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] synonym: "inhibition of primary amine oxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity" NARROW [GOC:TermGenie] synonym: "negative regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] synonym: "negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008131 ! primary amine oxidase activity relationship: negatively_regulates GO:0008131 ! primary amine oxidase activity created_by: ecu creation_date: 2013-07-08T13:27:59Z [Term] id: GO:1902284 name: neuron projection extension involved in neuron projection guidance namespace: biological_process def: "Any neuron projection extension that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] synonym: "neurite extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron process guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron projection guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuron protrusion guidance" NARROW [GOC:TermGenie] synonym: "neurite extension involved in neuronal cell projection guidance" NARROW [GOC:TermGenie] synonym: "neuron process extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron process extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron process extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuron protrusion extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "neuronal cell projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] is_a: GO:1990138 ! neuron projection extension intersection_of: GO:1990138 ! neuron projection extension intersection_of: part_of GO:0097485 ! neuron projection guidance relationship: part_of GO:0097485 ! neuron projection guidance created_by: pr creation_date: 2013-07-08T15:55:17Z [Term] id: GO:1902285 name: semaphorin-plexin signaling pathway involved in neuron projection guidance namespace: biological_process def: "Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] synonym: "semaphorin-plexin signaling pathway involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in neurite guidance" NARROW [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in neuron process guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in neuron projection guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] is_a: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:0097485 ! neuron projection guidance relationship: part_of GO:0097485 ! neuron projection guidance created_by: pr creation_date: 2013-07-08T16:06:46Z [Term] id: GO:1902286 name: semaphorin-plexin signaling pathway involved in dendrite guidance namespace: biological_process def: "Any semaphorin-plexin signaling pathway that is involved in dendrite guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] synonym: "semaphorin-plexin signaling pathway involved in dendritic guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in dendrite guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in dendritic guidance" EXACT [GOC:TermGenie] is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:0070983 ! dendrite guidance relationship: part_of GO:0070983 ! dendrite guidance created_by: pr creation_date: 2013-07-08T16:06:55Z [Term] id: GO:1902287 name: semaphorin-plexin signaling pathway involved in axon guidance namespace: biological_process def: "Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] synonym: "semaphorin-plexin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "semaphorin-plexin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "semaphorin-plexin signalling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance created_by: pr creation_date: 2013-07-08T16:07:03Z [Term] id: GO:1902288 name: regulation of defense response to oomycetes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002229 ! defense response to oomycetes relationship: regulates GO:0002229 ! defense response to oomycetes created_by: ms creation_date: 2013-07-09T13:45:32Z [Term] id: GO:1902289 name: negative regulation of defense response to oomycetes namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] synonym: "down regulation of defense response to oomycetes" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to oomycetes" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to oomycetes" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to oomycetes" NARROW [GOC:TermGenie] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:1902288 ! regulation of defense response to oomycetes intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002229 ! defense response to oomycetes relationship: negatively_regulates GO:0002229 ! defense response to oomycetes created_by: ms creation_date: 2013-07-09T13:45:37Z [Term] id: GO:1902290 name: positive regulation of defense response to oomycetes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] synonym: "activation of defense response to oomycetes" NARROW [GOC:TermGenie] synonym: "up regulation of defense response to oomycetes" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to oomycetes" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to oomycetes" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:1902288 ! regulation of defense response to oomycetes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002229 ! defense response to oomycetes relationship: positively_regulates GO:0002229 ! defense response to oomycetes created_by: ms creation_date: 2013-07-09T13:45:43Z [Term] id: GO:1902291 name: cell cycle DNA replication DNA ligation namespace: biological_process def: "Any DNA ligation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA ligation involved in cell cycle DNA replication" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051104 ! DNA-dependent DNA replication DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-09T16:05:45Z [Term] id: GO:1902292 name: cell cycle DNA replication initiation namespace: biological_process def: "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA endoreduplication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA re-replication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA replication initiation involved in cell cycle DNA replication" EXACT [] synonym: "DNA-dependent DNA replication initiation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0006270 ! DNA replication initiation is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-09T16:05:54Z [Term] id: GO:1902294 name: cell cycle DNA replication termination namespace: biological_process def: "Any DNA replication termination that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication termination involved in cell cycle DNA replication" EXACT [] is_a: GO:0006274 ! DNA replication termination is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006274 ! DNA replication termination intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-09T16:06:11Z [Term] id: GO:1902295 name: synthesis of RNA primer involved in cell cycle DNA replication namespace: biological_process def: "Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication, synthesis of RNA primer involved in cell cycle DNA replication" EXACT [] synonym: "replication priming involved in cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:0006269 ! DNA replication, synthesis of RNA primer is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-09T16:06:26Z [Term] id: GO:1902296 name: DNA strand elongation involved in cell cycle DNA replication namespace: biological_process def: "Any DNA strand elongation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication elongation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA strand elongation during DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:0006271 ! DNA strand elongation involved in DNA replication is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006271 ! DNA strand elongation involved in DNA replication intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-10T11:47:02Z [Term] id: GO:1902297 name: cell cycle DNA replication DNA unwinding namespace: biological_process def: "Any DNA unwinding that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA unwinding during replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] synonym: "DNA unwinding factor involved in cell cycle DNA replication" RELATED [GOC:TermGenie] synonym: "DNA unwinding involved in cell cycle DNA replication" EXACT [] is_a: GO:0006268 ! DNA unwinding involved in DNA replication is_a: GO:0022402 ! cell cycle process intersection_of: GO:0006268 ! DNA unwinding involved in DNA replication intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-10T11:47:10Z [Term] id: GO:1902298 name: cell cycle DNA replication maintenance of fidelity namespace: biological_process def: "Any maintenance of fidelity that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] synonym: "maintenance of fidelity involved in cell cycle DNA replication" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity intersection_of: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-10T11:47:19Z [Term] id: GO:1902299 name: pre-replicative complex assembly involved in cell cycle DNA replication namespace: biological_process def: "Any pre-replicative complex assembly that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "pre-RC assembly involved in cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "pre-replication complex assembly involved in cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:0022402 ! cell cycle process is_a: GO:0036388 ! pre-replicative complex assembly intersection_of: GO:0036388 ! pre-replicative complex assembly intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication created_by: jl creation_date: 2013-07-10T11:47:28Z [Term] id: GO:1902300 name: galactarate transmembrane transport namespace: biological_process alt_id: GO:0042871 def: "The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "D-galactarate transport" RELATED [] synonym: "galactarate transport" RELATED [] synonym: "galactaric acid anion transport" EXACT [] is_a: GO:0042869 ! aldarate transmembrane transport created_by: pr creation_date: 2013-07-16T07:11:45Z [Term] id: GO:1902301 name: galactarate transmembrane transporter activity namespace: molecular_function alt_id: GO:0042877 def: "Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "D-galactarate transmembrane transporter activity" RELATED [] synonym: "galactaric acid anion transmembrane transporter activity" EXACT [] is_a: GO:0042876 ! aldarate transmembrane transporter activity relationship: part_of GO:1902300 ! galactarate transmembrane transport created_by: pr creation_date: 2013-07-16T07:26:36Z [Term] id: GO:1902305 name: regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035725 ! sodium ion transmembrane transport relationship: regulates GO:0035725 ! sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:33:53Z [Term] id: GO:1902306 name: negative regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0010766 ! negative regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035725 ! sodium ion transmembrane transport relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:34:01Z [Term] id: GO:1902307 name: positive regulation of sodium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0010765 ! positive regulation of sodium ion transport is_a: GO:1902305 ! regulation of sodium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035725 ! sodium ion transmembrane transport relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport created_by: rl creation_date: 2013-07-18T13:34:18Z [Term] id: GO:1902308 name: regulation of peptidyl-serine dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] is_a: GO:0035304 ! regulation of protein dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070262 ! peptidyl-serine dephosphorylation relationship: regulates GO:0070262 ! peptidyl-serine dephosphorylation created_by: rl creation_date: 2013-07-19T10:34:59Z [Term] id: GO:1902309 name: negative regulation of peptidyl-serine dephosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] synonym: "down regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] synonym: "inhibition of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie] is_a: GO:0035308 ! negative regulation of protein dephosphorylation is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070262 ! peptidyl-serine dephosphorylation relationship: negatively_regulates GO:0070262 ! peptidyl-serine dephosphorylation created_by: rl creation_date: 2013-07-19T10:35:07Z [Term] id: GO:1902310 name: positive regulation of peptidyl-serine dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] synonym: "activation of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie] synonym: "up regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] is_a: GO:0035307 ! positive regulation of protein dephosphorylation is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070262 ! peptidyl-serine dephosphorylation relationship: positively_regulates GO:0070262 ! peptidyl-serine dephosphorylation created_by: rl creation_date: 2013-07-19T10:35:15Z [Term] id: GO:1902311 name: regulation of copper ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] synonym: "regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "regulation of copper ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:0010959 ! regulation of metal ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035434 ! copper ion transmembrane transport relationship: regulates GO:0035434 ! copper ion transmembrane transport created_by: di creation_date: 2013-07-19T20:59:28Z [Term] id: GO:1902312 name: negative regulation of copper ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] synonym: "down regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of copper cation transmembrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of copper ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of copper ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "negative regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "negative regulation of copper ion membrane transport" EXACT [GOC:TermGenie] is_a: GO:1902311 ! regulation of copper ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035434 ! copper ion transmembrane transport relationship: negatively_regulates GO:0035434 ! copper ion transmembrane transport created_by: di creation_date: 2013-07-19T20:59:37Z [Term] id: GO:1902313 name: positive regulation of copper ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] synonym: "activation of copper cation transmembrane transport" NARROW [GOC:TermGenie] synonym: "activation of copper ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of copper ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "positive regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "positive regulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of copper ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:1902311 ! regulation of copper ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035434 ! copper ion transmembrane transport relationship: positively_regulates GO:0035434 ! copper ion transmembrane transport created_by: di creation_date: 2013-07-19T20:59:45Z [Term] id: GO:1902314 name: hydroquinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroquinone." [GOC:bhm, GOC:TermGenie, pmid:15667223] synonym: "quinol binding" EXACT [] is_a: GO:0048037 ! cofactor binding is_a: GO:0097159 ! organic cyclic compound binding created_by: bhm creation_date: 2013-07-22T10:10:12Z [Term] id: GO:1902315 name: nuclear cell cycle DNA replication initiation namespace: biological_process def: "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA re-replication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA replication initiation involved in nuclear cell cycle DNA replication" EXACT [] is_a: GO:1902292 ! cell cycle DNA replication initiation intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-23T14:00:01Z [Term] id: GO:1902317 name: nuclear DNA replication termination namespace: biological_process def: "Any DNA replication termination that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication termination involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA replication termination involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA replication termination involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "DNA replication termination involved in nuclear cell cycle DNA replication" EXACT [] is_a: GO:1902294 ! cell cycle DNA replication termination intersection_of: GO:0006274 ! DNA replication termination intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-23T14:00:17Z [Term] id: GO:1902318 name: synthesis of RNA primer involved in nuclear cell cycle DNA replication namespace: biological_process def: "Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication, synthesis of RNA primer involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "replication priming involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "replication priming involved in DNA replication involved in S phase" RELATED [GOC:TermGenie] synonym: "replication priming involved in DNA replication involved in S-phase" RELATED [GOC:TermGenie] synonym: "replication priming involved in nuclear cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-23T14:00:33Z [Term] id: GO:1902319 name: DNA strand elongation involved in nuclear cell cycle DNA replication namespace: biological_process def: "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication intersection_of: GO:0022616 ! DNA strand elongation intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-23T14:00:41Z [Term] id: GO:1902320 name: nuclear DNA replication DNA duplex unwinding namespace: biological_process def: "Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA duplex unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA duplex unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA duplex unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "DNA duplex unwinding involved in nuclear cell cycle DNA replication" EXACT [] synonym: "DNA unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "DNA unwinding involved in nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "duplex DNA melting involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "duplex DNA melting involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "duplex DNA melting involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding intersection_of: GO:0032508 ! DNA duplex unwinding intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-23T14:00:49Z [Term] id: GO:1902321 name: methyl-branched fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid." [GOC:kmv, GOC:TermGenie, PMID:15340492] synonym: "methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0097089 ! methyl-branched fatty acid metabolic process created_by: kmv creation_date: 2013-07-23T20:40:46Z [Term] id: GO:1902322 name: regulation of methyl-branched fatty acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] synonym: "regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process relationship: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process created_by: kmv creation_date: 2013-07-24T20:15:15Z [Term] id: GO:1902323 name: negative regulation of methyl-branched fatty acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] synonym: "down regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "down regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "downregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of methyl-branched fatty acid formation" NARROW [GOC:TermGenie] synonym: "inhibition of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process relationship: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process created_by: kmv creation_date: 2013-07-24T20:15:23Z [Term] id: GO:1902324 name: positive regulation of methyl-branched fatty acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] synonym: "activation of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie] synonym: "activation of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of methyl-branched fatty acid formation" NARROW [GOC:TermGenie] synonym: "activation of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "up regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] synonym: "upregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process relationship: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process created_by: kmv creation_date: 2013-07-24T20:15:31Z [Term] id: GO:1902325 name: negative regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952] synonym: "down regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of chlorophyll anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll formation" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process relationship: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process created_by: tb creation_date: 2013-07-24T22:47:29Z [Term] id: GO:1902326 name: positive regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952] synonym: "activation of chlorophyll anabolism" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll formation" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "positive regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie] is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015995 ! chlorophyll biosynthetic process relationship: positively_regulates GO:0015995 ! chlorophyll biosynthetic process created_by: tb creation_date: 2013-07-24T22:47:37Z [Term] id: GO:1902327 name: bacterial-type DNA replication DNA ligation namespace: biological_process def: "Any DNA ligation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA ligation involved in bacterial-type DNA replication" EXACT [] is_a: GO:1902291 ! cell cycle DNA replication DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0044787 ! bacterial-type DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: jl creation_date: 2013-07-25T10:47:46Z [Term] id: GO:1902328 name: bacterial-type DNA replication initiation namespace: biological_process def: "Any DNA replication initiation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA endoreduplication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie] synonym: "DNA re-replication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie] synonym: "DNA replication initiation involved in bacterial-type DNA replication" EXACT [] synonym: "DNA-dependent DNA replication initiation involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] is_a: GO:1902292 ! cell cycle DNA replication initiation intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0044787 ! bacterial-type DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: jl creation_date: 2013-07-25T10:48:02Z [Term] id: GO:1902329 name: bacterial-type DNA replication termination namespace: biological_process def: "Any DNA replication termination that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication termination involved in bacterial-type DNA replication" EXACT [] is_a: GO:1902294 ! cell cycle DNA replication termination intersection_of: GO:0006274 ! DNA replication termination intersection_of: part_of GO:0044787 ! bacterial-type DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: jl creation_date: 2013-07-25T10:48:10Z [Term] id: GO:1902330 name: synthesis of RNA primer involved in bacterial-type DNA replication namespace: biological_process def: "Any synthesis of RNA primer that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "replication priming involved in bacterial-type DNA replication" RELATED [GOC:TermGenie] is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer intersection_of: part_of GO:0044787 ! bacterial-type DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: jl creation_date: 2013-07-25T10:48:18Z [Term] id: GO:1902331 name: obsolete DNA strand elongation involved in bacterial-type DNA replication namespace: biological_process def: "OBSOLETE. Any DNA strand elongation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] comment: This term was obsoleted because it does not represent a distinct function from its parent, DNA strand elongation involved in DNA replication. is_obsolete: true created_by: jl creation_date: 2013-07-25T10:48:26Z [Term] id: GO:1902332 name: bacterial-type DNA replication DNA duplex unwinding namespace: biological_process def: "Any DNA duplex unwinding that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA duplex unwinding involved in bacterial-type DNA replication" EXACT [] synonym: "DNA unwinding involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] synonym: "duplex DNA melting involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding intersection_of: GO:0032508 ! DNA duplex unwinding intersection_of: part_of GO:0044787 ! bacterial-type DNA replication relationship: part_of GO:0044787 ! bacterial-type DNA replication created_by: jl creation_date: 2013-07-25T10:48:34Z [Term] id: GO:1902333 name: nuclear DNA replication DNA ligation namespace: biological_process def: "Any DNA ligation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA ligation involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA ligation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA ligation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "DNA ligation involved in nuclear cell cycle DNA replication" EXACT [] is_a: GO:1902291 ! cell cycle DNA replication DNA ligation intersection_of: GO:0006266 ! DNA ligation intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication created_by: jl creation_date: 2013-07-25T10:55:56Z [Term] id: GO:1902334 name: fructose export from vacuole to cytoplasm namespace: biological_process def: "The directed movement of fructose from vacuole to cytoplasm." [GOC:TermGenie, PMID:23583552] synonym: "fructose transport from vacuole to cytoplasm" EXACT [] is_a: GO:0015755 ! fructose transmembrane transport is_a: GO:0033231 ! carbohydrate export is_a: GO:0034486 ! vacuolar transmembrane transport created_by: tb creation_date: 2013-07-26T22:18:12Z [Term] id: GO:1902335 name: obsolete positive chemotaxis involved in neuron migration namespace: biological_process def: "OBSOLETE. Any positive chemotaxis that is involved in neuron migration." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "chemoattraction involved in neuron chemotaxis" EXACT [GOC:TermGenie] synonym: "chemoattraction involved in neuron guidance" RELATED [GOC:TermGenie] synonym: "chemoattraction involved in neuron migration" EXACT [GOC:TermGenie] synonym: "chemoattraction involved in neuronal migration" EXACT [GOC:TermGenie] synonym: "positive chemotaxis involved in neuron chemotaxis" EXACT [GOC:TermGenie] synonym: "positive chemotaxis involved in neuron guidance" RELATED [GOC:TermGenie] synonym: "positive chemotaxis involved in neuron migration" EXACT [] synonym: "positive chemotaxis involved in neuronal migration" EXACT [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2013-07-29T12:52:01Z [Term] id: GO:1902336 name: positive regulation of retinal ganglion cell axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] synonym: "activation of retinal ganglion cell axon guidance" NARROW [GOC:TermGenie] synonym: "activation of retinal ganglion cell axon pathfinding" NARROW [GOC:TermGenie] synonym: "positive regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance is_a: GO:1902669 ! positive regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance relationship: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance created_by: rl creation_date: 2013-07-29T13:02:25Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis created_by: sart creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902340 name: negative regulation of chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030261 ! chromosome condensation relationship: negatively_regulates GO:0030261 ! chromosome condensation created_by: dgf creation_date: 2013-07-29T20:54:14Z [Term] id: GO:1902341 name: xylitol transport namespace: biological_process def: "The directed movement of a xylitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose." [GOC:TermGenie, PMID:23475614] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport created_by: se creation_date: 2013-07-30T16:04:38Z [Term] id: GO:1902342 name: xylitol export namespace: biological_process def: "The directed movement of xylitol out of a cell or organelle." [GOC:TermGenie, PMID:23475614] is_a: GO:0033231 ! carbohydrate export is_a: GO:1902341 ! xylitol transport created_by: se creation_date: 2013-07-30T16:09:55Z [Term] id: GO:1902343 name: regulation of maltose transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015768 ! maltose transport relationship: regulates GO:0015768 ! maltose transport created_by: dph creation_date: 2013-08-01T17:16:18Z [Term] id: GO:1902344 name: negative regulation of maltose transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] synonym: "down regulation of maltose transport" EXACT [GOC:TermGenie] synonym: "down-regulation of maltose transport" EXACT [GOC:TermGenie] synonym: "downregulation of maltose transport" EXACT [GOC:TermGenie] synonym: "inhibition of maltose transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1902343 ! regulation of maltose transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015768 ! maltose transport relationship: negatively_regulates GO:0015768 ! maltose transport created_by: dph creation_date: 2013-08-01T17:16:26Z [Term] id: GO:1902345 name: positive regulation of maltose transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] synonym: "activation of maltose transport" NARROW [GOC:TermGenie] synonym: "up regulation of maltose transport" EXACT [GOC:TermGenie] synonym: "up-regulation of maltose transport" EXACT [GOC:TermGenie] synonym: "upregulation of maltose transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1902343 ! regulation of maltose transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015768 ! maltose transport relationship: positively_regulates GO:0015768 ! maltose transport created_by: dph creation_date: 2013-08-01T17:16:34Z [Term] id: GO:1902346 name: meiotic strand displacement involved in double-strand break repair via SDSA namespace: biological_process def: "Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA)." [GOC:al, GOC:TermGenie, PMID:22723423] synonym: "meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] synonym: "meiotic D-loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie] synonym: "meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] synonym: "meiotic D-loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie] synonym: "meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] synonym: "meiotic displacement loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie] synonym: "meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] synonym: "meiotic displacement loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie] synonym: "meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing" EXACT [] synonym: "meiotic strand displacement involved in mitotic gene conversion" RELATED [GOC:TermGenie] synonym: "meiotic strand displacement involved in SDSA" BROAD [] is_a: GO:0000714 ! meiotic strand displacement intersection_of: GO:0000714 ! meiotic strand displacement intersection_of: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing created_by: pr creation_date: 2013-08-07T12:56:20Z [Term] id: GO:1902347 name: response to strigolactone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound created_by: dhl creation_date: 2013-08-08T18:44:57Z [Term] id: GO:1902348 name: cellular response to strigolactone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902347 ! response to strigolactone created_by: dhl creation_date: 2013-08-08T18:45:05Z [Term] id: GO:1902349 name: response to chloroquine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic created_by: kmv creation_date: 2013-08-13T19:29:25Z [Term] id: GO:1902350 name: cellular response to chloroquine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1902349 ! response to chloroquine created_by: kmv creation_date: 2013-08-13T19:29:33Z [Term] id: GO:1902351 name: response to imidacloprid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0017085 ! response to insecticide is_a: GO:0042493 ! response to drug created_by: kmv creation_date: 2013-08-13T19:33:15Z [Term] id: GO:1902352 name: negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:rn, GOC:TermGenie, PMID:23223039] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1900435 ! negative regulation of filamentous growth of a population of unicellular organisms in response to starvation intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation created_by: bf creation_date: 2013-08-14T09:35:43Z [Term] id: GO:1902353 name: positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter by pheromones that results in positive regulation of induction of conjugation with cellular fusion." [GOC:rn, GOC:TermGenie, PMID:23872066] synonym: "up regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] synonym: "up-regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] synonym: "upregulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] is_a: GO:0046020 ! negative regulation of transcription from RNA polymerase II promoter by pheromones is_a: GO:1904788 ! positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0046020 ! negative regulation of transcription from RNA polymerase II promoter by pheromones intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion created_by: bf creation_date: 2013-08-14T09:45:21Z [Term] id: GO:1902354 name: blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment namespace: biological_process def: "Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350] is_a: GO:0097497 ! blood vessel endothelial cell delamination intersection_of: GO:0097497 ! blood vessel endothelial cell delamination intersection_of: part_of GO:0097496 ! blood vessel lumen ensheathment relationship: part_of GO:0097496 ! blood vessel lumen ensheathment created_by: pr creation_date: 2013-08-14T10:22:00Z [Term] id: GO:1902355 name: endothelial tube lumen extension involved in blood vessel lumen ensheathment namespace: biological_process def: "Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350] is_a: GO:0097498 ! endothelial tube lumen extension intersection_of: GO:0097498 ! endothelial tube lumen extension intersection_of: part_of GO:0097496 ! blood vessel lumen ensheathment relationship: part_of GO:0097496 ! blood vessel lumen ensheathment created_by: pr creation_date: 2013-08-14T10:22:09Z [Term] id: GO:1902356 name: oxaloacetate(2-) transmembrane transport namespace: biological_process def: "The directed movement of oxaloacetate(2-) across a membrane." [GOC:dph, GOC:TermGenie, PMID:18682385] is_a: GO:0015729 ! oxaloacetate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: dph creation_date: 2013-08-14T14:40:37Z [Term] id: GO:1902357 name: 2-isopropylmalate(2-) transmembrane transport namespace: biological_process def: "The process in which 2-isopropylmalate(2-) is transported across a membrane." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:18682385] is_a: GO:0034659 ! isopropylmalate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: dph creation_date: 2013-08-14T14:43:49Z [Term] id: GO:1902358 name: sulfate transmembrane transport namespace: biological_process def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] is_a: GO:0008272 ! sulfate transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: dph creation_date: 2013-08-14T14:46:04Z [Term] id: GO:1902359 name: Notch signaling pathway involved in somitogenesis namespace: biological_process def: "Any Notch signaling pathway that is involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] synonym: "N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:0001756 ! somitogenesis relationship: part_of GO:0001756 ! somitogenesis created_by: dph creation_date: 2013-08-14T17:31:43Z [Term] id: GO:1902360 name: conversion of ds siRNA to ss siRNA involved in chromatin silencing by small RNA namespace: biological_process def: "Any conversion of ds siRNA to ss siRNA that is involved in chromatin silencing by small RNA." [GOC:TermGenie, GOC:vw, PMID:19239886] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in chromatin silencing by small RNA" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA interference-like chromatin silencing" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA-mediated chromatin silencing" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNA-mediated transcriptional silencing" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNAi-directed chromatin silencing" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in RNAi-like chromatin silencing" RELATED [GOC:TermGenie] synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA. involved in small RNA-mediated heterochromatic silencing" RELATED [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in RNA interference-like chromatin silencing" EXACT [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated chromatin silencing" EXACT [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated transcriptional silencing" EXACT [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-directed chromatin silencing" EXACT [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-like chromatin silencing" EXACT [GOC:TermGenie] synonym: "conversion of ds siRNA to ss siRNA involved in small RNA-mediated heterochromatic silencing" EXACT [GOC:TermGenie] is_a: GO:0036404 ! conversion of ds siRNA to ss siRNA intersection_of: GO:0036404 ! conversion of ds siRNA to ss siRNA intersection_of: part_of GO:0031048 ! chromatin silencing by small RNA relationship: part_of GO:0031048 ! chromatin silencing by small RNA created_by: bf creation_date: 2013-08-15T10:06:18Z [Term] id: GO:1902362 name: melanocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a melanocyte, the main structural component of the epidermis." [GOC:ic, GOC:TermGenie, PMID:20530876] synonym: "melanocyte apoptosis" NARROW [GOC:TermGenie] synonym: "melanophore apoptosis" NARROW [GOC:TermGenie] synonym: "melanophore apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process created_by: pr creation_date: 2013-08-15T16:35:45Z [Term] id: GO:1902363 name: regulation of protein localization to spindle pole body namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] synonym: "regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071988 ! protein localization to spindle pole body relationship: regulates GO:0071988 ! protein localization to spindle pole body created_by: vw creation_date: 2013-08-15T16:38:07Z [Term] id: GO:1902364 name: negative regulation of protein localization to spindle pole body namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] synonym: "down regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to spindle pole body" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to spindle pole body" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] is_a: GO:1902363 ! regulation of protein localization to spindle pole body is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071988 ! protein localization to spindle pole body relationship: negatively_regulates GO:0071988 ! protein localization to spindle pole body created_by: vw creation_date: 2013-08-15T16:38:23Z [Term] id: GO:1902365 name: positive regulation of protein localization to spindle pole body namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] synonym: "activation of protein localisation to spindle pole body" NARROW [GOC:TermGenie] synonym: "activation of protein localization to spindle pole body" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] is_a: GO:1902363 ! regulation of protein localization to spindle pole body is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071988 ! protein localization to spindle pole body relationship: positively_regulates GO:0071988 ! protein localization to spindle pole body created_by: vw creation_date: 2013-08-15T16:38:31Z [Term] id: GO:1902366 name: regulation of Notch signaling pathway involved in somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] synonym: "regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] is_a: GO:0008593 ! regulation of Notch signaling pathway is_a: GO:0014807 ! regulation of somitogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis relationship: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis created_by: dph creation_date: 2013-08-20T18:24:23Z [Term] id: GO:1902367 name: negative regulation of Notch signaling pathway involved in somitogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] synonym: "down regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "down-regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "downregulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of N signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of N signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of N signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of N signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch-receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] synonym: "inhibition of Notch-receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] synonym: "negative regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] is_a: GO:0045746 ! negative regulation of Notch signaling pathway is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1902366 ! regulation of Notch signaling pathway involved in somitogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis relationship: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis created_by: dph creation_date: 2013-08-20T18:27:20Z [Term] id: GO:1902368 name: heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region namespace: biological_process def: "Any heterochromatin maintenance that is involved in chromatin silencing at centromere outer repeat region." [GOC:TermGenie, GOC:vw, PMID:21289066] synonym: "heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats" EXACT [GOC:vw] synonym: "heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] is_a: GO:0070870 ! heterochromatin maintenance involved in chromatin silencing intersection_of: GO:0070829 ! heterochromatin maintenance intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region created_by: bf creation_date: 2013-08-21T10:13:39Z [Term] id: GO:1902369 name: negative regulation of RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006401 ! RNA catabolic process relationship: negatively_regulates GO:0006401 ! RNA catabolic process created_by: bf creation_date: 2013-08-22T14:59:39Z [Term] id: GO:1902370 name: regulation of tRNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie] synonym: "regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of tRNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016078 ! tRNA catabolic process relationship: regulates GO:0016078 ! tRNA catabolic process created_by: bf creation_date: 2013-08-22T15:08:12Z [Term] id: GO:1902371 name: negative regulation of tRNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22919049] synonym: "down regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of tRNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of tRNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tRNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of tRNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of tRNA degradation" EXACT [GOC:TermGenie] is_a: GO:1902369 ! negative regulation of RNA catabolic process is_a: GO:1902370 ! regulation of tRNA catabolic process is_a: GO:1903327 ! negative regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016078 ! tRNA catabolic process relationship: negatively_regulates GO:0016078 ! tRNA catabolic process created_by: bf creation_date: 2013-08-22T15:08:20Z [Term] id: GO:1902372 name: positive regulation of tRNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie] synonym: "activation of tRNA breakdown" NARROW [GOC:TermGenie] synonym: "activation of tRNA catabolic process" NARROW [GOC:TermGenie] synonym: "activation of tRNA catabolism" NARROW [GOC:TermGenie] synonym: "activation of tRNA degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA degradation" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:1902370 ! regulation of tRNA catabolic process is_a: GO:1903328 ! positive regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016078 ! tRNA catabolic process relationship: positively_regulates GO:0016078 ! tRNA catabolic process created_by: bf creation_date: 2013-08-22T15:08:29Z [Term] id: GO:1902373 name: negative regulation of mRNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] synonym: "down regulation of mRNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA decay" RELATED [GOC:TermGenie] synonym: "down regulation of mRNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA decay" RELATED [GOC:TermGenie] synonym: "down-regulation of mRNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA decay" RELATED [GOC:TermGenie] synonym: "downregulation of mRNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of mRNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA decay" RELATED [GOC:TermGenie] synonym: "inhibition of mRNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of mRNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA decay" RELATED [GOC:TermGenie] synonym: "negative regulation of mRNA degradation" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0061013 ! regulation of mRNA catabolic process is_a: GO:1902369 ! negative regulation of RNA catabolic process is_a: GO:1903312 ! negative regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006402 ! mRNA catabolic process relationship: negatively_regulates GO:0006402 ! mRNA catabolic process created_by: bf creation_date: 2013-08-22T15:16:19Z [Term] id: GO:1902374 name: regulation of rRNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:20160119] synonym: "regulation of rRNA breakdown" EXACT [GOC:TermGenie] synonym: "regulation of rRNA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of rRNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016075 ! rRNA catabolic process relationship: regulates GO:0016075 ! rRNA catabolic process created_by: bf creation_date: 2013-08-22T15:20:59Z [Term] id: GO:1902375 name: nuclear tRNA 3'-trailer cleavage, endonucleolytic namespace: biological_process def: "Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus." [GOC:TermGenie, PMID:23928301] synonym: "endonucleolytic tRNA 3'-end cleavage in cell nucleus" EXACT [GOC:TermGenie] synonym: "endonucleolytic tRNA 3'-end cleavage in nucleus" EXACT [GOC:TermGenie] synonym: "endonucleolytic tRNA 3'-trailer cleavage in cell nucleus" RELATED [GOC:TermGenie] synonym: "endonucleolytic tRNA 3'-trailer cleavage in nucleus" RELATED [GOC:TermGenie] synonym: "tRNA 3'-end cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie] synonym: "tRNA 3'-end cleavage, endonucleolytic in nucleus" EXACT [GOC:TermGenie] synonym: "tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie] is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic intersection_of: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic intersection_of: occurs_in GO:0005634 ! nucleus relationship: occurs_in GO:0005634 ! nucleus created_by: al creation_date: 2013-08-30T09:17:30Z [Term] id: GO:1902376 name: obsolete protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. Any protein denaturation that is involved in proteasomal ubiquitin-dependent protein catabolic process." [GOC:TermGenie, PMID:21091378] comment: This term was made obsolete because it was poorly defined and the intended usage was unclear. synonym: "protein denaturation involved in proteasomal pathway" EXACT [GOC:TermGenie] synonym: "protein denaturation involved in proteasomal processing" RELATED [GOC:TermGenie] synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:TermGenie] synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:TermGenie] synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:TermGenie] synonym: "protein denaturation involved in proteasome pathway" RELATED [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2013-08-30T09:29:14Z [Term] id: GO:1902377 name: nuclear rDNA heterochromatin namespace: cellular_component def: "Any rDNA heterochromatin that is part of a nucleus." [GOC:TermGenie, PMID:20661445] synonym: "rDNA heterochromatin of cell nucleus" EXACT [GOC:TermGenie] synonym: "rDNA heterochromatin of nucleus" EXACT [GOC:TermGenie] synonym: "ribosomal DNA heterochromatin of cell nucleus" EXACT [GOC:TermGenie] synonym: "ribosomal DNA heterochromatin of nucleus" EXACT [GOC:TermGenie] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0033553 ! rDNA heterochromatin intersection_of: GO:0033553 ! rDNA heterochromatin intersection_of: part_of GO:0005634 ! nucleus created_by: al creation_date: 2013-08-30T09:59:42Z [Term] id: GO:1902378 name: VEGF-activated neuropilin signaling pathway involved in axon guidance namespace: biological_process def: "Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] synonym: "VEGF-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "VEGF-activated neuropilin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "VEGF-Npn-1 signaling involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "VEGF-Npn-1 signaling involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "VEGF-Npn-1 signaling involved in axon guidance" NARROW [GOC:TermGenie] synonym: "VEGF-Npn-1 signaling involved in axon pathfinding" NARROW [GOC:TermGenie] is_a: GO:0038190 ! VEGF-activated neuropilin signaling pathway intersection_of: GO:0038190 ! VEGF-activated neuropilin signaling pathway intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance created_by: bf creation_date: 2013-09-02T13:44:13Z [Term] id: GO:1902379 name: chemoattractant activity involved in axon guidance namespace: molecular_function def: "Any chemoattractant activity that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] synonym: "chemoattractant activity involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "chemoattractant activity involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "chemoattractant activity involved in axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0042056 ! chemoattractant activity intersection_of: GO:0042056 ! chemoattractant activity intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0061642 ! chemoattraction of axon created_by: bf creation_date: 2013-09-02T13:49:35Z [Term] id: GO:1902380 name: positive regulation of endoribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endoribonuclease activity." [GOC:bf, GOC:TermGenie] synonym: "activation of endonuclease G activity" RELATED [GOC:TermGenie] synonym: "activation of endoribonuclease activity" NARROW [GOC:TermGenie] synonym: "positive regulation of endonuclease G activity" RELATED [GOC:TermGenie] synonym: "up regulation of endonuclease G activity" RELATED [GOC:TermGenie] synonym: "up regulation of endoribonuclease activity" EXACT [GOC:TermGenie] synonym: "up-regulation of endonuclease G activity" RELATED [GOC:TermGenie] synonym: "up-regulation of endoribonuclease activity" EXACT [GOC:TermGenie] synonym: "upregulation of endonuclease G activity" RELATED [GOC:TermGenie] synonym: "upregulation of endoribonuclease activity" EXACT [GOC:TermGenie] is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:0060699 ! regulation of endoribonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004521 ! endoribonuclease activity relationship: positively_regulates GO:0004521 ! endoribonuclease activity created_by: bf creation_date: 2013-09-02T14:14:29Z [Term] id: GO:1902381 name: 11-oxo-beta-amyrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] synonym: "11-oxo-beta-amyrin metabolism" EXACT [GOC:TermGenie] is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process created_by: ms creation_date: 2013-09-03T12:55:29Z [Term] id: GO:1902382 name: 11-oxo-beta-amyrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] synonym: "11-oxo-beta-amyrin breakdown" EXACT [GOC:TermGenie] synonym: "11-oxo-beta-amyrin catabolism" EXACT [GOC:TermGenie] synonym: "11-oxo-beta-amyrin degradation" EXACT [GOC:TermGenie] is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process created_by: ms creation_date: 2013-09-03T12:55:38Z [Term] id: GO:1902383 name: 11-oxo-beta-amyrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] synonym: "11-oxo-beta-amyrin anabolism" EXACT [GOC:TermGenie] synonym: "11-oxo-beta-amyrin biosynthesis" EXACT [GOC:TermGenie] synonym: "11-oxo-beta-amyrin formation" EXACT [GOC:TermGenie] synonym: "11-oxo-beta-amyrin synthesis" EXACT [GOC:TermGenie] is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process created_by: ms creation_date: 2013-09-03T12:55:46Z [Term] id: GO:1902384 name: glycyrrhetinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, pmid:22128119] synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie] is_a: GO:0017144 ! drug metabolic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: ms creation_date: 2013-09-03T12:55:55Z [Term] id: GO:1902385 name: glycyrrhetinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate." [GOC:TermGenie, pmid:22128119] synonym: "glycyrrhetinate breakdown" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie] is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1902384 ! glycyrrhetinate metabolic process created_by: ms creation_date: 2013-09-03T12:56:10Z [Term] id: GO:1902386 name: glycyrrhetinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycyrrhetinate." [GOC:TermGenie, pmid:22128119] synonym: "glycyrrhetinate anabolism" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate biosynthesis" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate formation" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1902384 ! glycyrrhetinate metabolic process created_by: ms creation_date: 2013-09-03T12:56:19Z [Term] id: GO:1902387 name: ceramide 1-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with ceramide 1-phosphate." [GOC:TermGenie, PMID:23863933] is_a: GO:0005543 ! phospholipid binding is_a: GO:0097001 ! ceramide binding created_by: uh creation_date: 2013-09-05T05:51:08Z [Term] id: GO:1902388 name: ceramide 1-phosphate transfer activity namespace: molecular_function def: "Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:TermGenie, PMID:23863933] synonym: "ceramide 1-phosphate carrier activity" EXACT [] synonym: "ceramide 1-phosphate transporter activity" BROAD [] synonym: "intermembrane ceramide 1-phosphate transfer activity" NARROW [] xref: Reactome:R-HSA-5339535 "GLTPD1 transports C1P from plasma membrane to Golgi membrane" is_a: GO:0120014 ! phospholipid transfer activity is_a: GO:0120017 ! ceramide transfer activity relationship: part_of GO:1902389 ! ceramide 1-phosphate transport created_by: uh creation_date: 2013-09-05T05:57:55Z [Term] id: GO:1902389 name: ceramide 1-phosphate transport namespace: biological_process def: "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:23863933] is_a: GO:0015914 ! phospholipid transport is_a: GO:0035627 ! ceramide transport created_by: uh creation_date: 2013-09-05T06:02:35Z [Term] id: GO:1902390 name: regulation of N-terminal peptidyl-serine acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279] is_a: GO:1901983 ! regulation of protein acetylation is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017198 ! N-terminal peptidyl-serine acetylation relationship: regulates GO:0017198 ! N-terminal peptidyl-serine acetylation created_by: al creation_date: 2013-09-11T14:46:45Z [Term] id: GO:1902391 name: positive regulation of N-terminal peptidyl-serine acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279] synonym: "activation of N-terminal peptidyl-serine acetylation" NARROW [GOC:TermGenie] synonym: "up regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] synonym: "up-regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] synonym: "upregulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] is_a: GO:1901985 ! positive regulation of protein acetylation is_a: GO:1902390 ! regulation of N-terminal peptidyl-serine acetylation is_a: GO:1903319 ! positive regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017198 ! N-terminal peptidyl-serine acetylation relationship: positively_regulates GO:0017198 ! N-terminal peptidyl-serine acetylation created_by: al creation_date: 2013-09-11T14:46:54Z [Term] id: GO:1902392 name: regulation of exodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:1905777 ! regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004529 ! exodeoxyribonuclease activity relationship: regulates GO:0004529 ! exodeoxyribonuclease activity created_by: jl creation_date: 2013-09-11T14:56:14Z [Term] id: GO:1902393 name: negative regulation of exodeoxyribonuclease activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie] synonym: "down regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] synonym: "down-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] synonym: "downregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] synonym: "inhibition of exodeoxyribonuclease activity" NARROW [GOC:TermGenie] is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity is_a: GO:1905778 ! negative regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004529 ! exodeoxyribonuclease activity relationship: negatively_regulates GO:0004529 ! exodeoxyribonuclease activity created_by: jl creation_date: 2013-09-11T14:56:23Z [Term] id: GO:1902394 name: positive regulation of exodeoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie, PMID:1234] synonym: "activation of exodeoxyribonuclease activity" NARROW [GOC:TermGenie] synonym: "up regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] synonym: "up-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] synonym: "upregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity is_a: GO:1905779 ! positive regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004529 ! exodeoxyribonuclease activity relationship: positively_regulates GO:0004529 ! exodeoxyribonuclease activity created_by: jl creation_date: 2013-09-11T14:56:38Z [Term] id: GO:1902395 name: regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity." [GOC:TermGenie, PMID:23612965] synonym: "regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [GOC:TermGenie] synonym: "regulation of 1-deoxyxylulose-5-phosphate synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of DOXP synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of DXP-synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008661 ! 1-deoxy-D-xylulose-5-phosphate synthase activity relationship: regulates GO:0008661 ! 1-deoxy-D-xylulose-5-phosphate synthase activity created_by: tb creation_date: 2013-09-11T21:12:25Z [Term] id: GO:1902396 name: protein localization to bicellular tight junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie] synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie] synonym: "protein localization in tight junction" EXACT [GOC:TermGenie] is_a: GO:0150105 ! protein localization to cell-cell junction created_by: tb creation_date: 2013-09-11T21:43:13Z [Term] id: GO:1902397 name: detection of stimulus involved in meiotic spindle checkpoint namespace: biological_process def: "Any detection of stimulus that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "perception of stimulus involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus detection involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] is_a: GO:0022414 ! reproductive process is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044779 ! meiotic spindle checkpoint relationship: part_of GO:0044779 ! meiotic spindle checkpoint created_by: jl creation_date: 2013-09-12T12:01:32Z [Term] id: GO:1902398 name: intracellular signal transduction involved in meiotic spindle checkpoint namespace: biological_process def: "Any intracellular signal transduction that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in meiotic spindle checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in meiotic spindle checkpoint" NARROW [GOC:TermGenie] is_a: GO:0072411 ! signal transduction involved in meiotic cell cycle checkpoint is_a: GO:0072416 ! signal transduction involved in spindle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0044779 ! meiotic spindle checkpoint relationship: part_of GO:0044779 ! meiotic spindle checkpoint created_by: jl creation_date: 2013-09-12T12:01:41Z [Term] id: GO:1902399 name: detection of stimulus involved in G1 DNA damage checkpoint namespace: biological_process def: "Any detection of stimulus that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "detection of stimulus involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "perception of stimulus involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "perception of stimulus involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus detection involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus detection involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus sensing involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044783 ! G1 DNA damage checkpoint relationship: part_of GO:0044783 ! G1 DNA damage checkpoint created_by: jl creation_date: 2013-09-12T12:01:49Z [Term] id: GO:1902400 name: intracellular signal transduction involved in G1 DNA damage checkpoint namespace: biological_process def: "Any intracellular signal transduction that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "intracellular signal transduction involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in G1 DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in G1/S DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in G1 DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in G1/S DNA damage checkpoint" NARROW [GOC:TermGenie] is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0044783 ! G1 DNA damage checkpoint relationship: part_of GO:0044783 ! G1 DNA damage checkpoint created_by: jl creation_date: 2013-09-12T12:01:58Z [Term] id: GO:1902401 name: detection of stimulus involved in mitotic DNA damage checkpoint namespace: biological_process def: "Any detection of stimulus that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "perception of stimulus involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus detection involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072400 ! detection of stimulus involved in mitotic DNA integrity checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044773 ! mitotic DNA damage checkpoint relationship: part_of GO:0044773 ! mitotic DNA damage checkpoint created_by: jl creation_date: 2013-09-12T12:07:12Z [Term] id: GO:1902402 name: signal transduction involved in mitotic DNA damage checkpoint namespace: biological_process def: "Any intracellular signal transduction that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] is_a: GO:0072422 ! signal transduction involved in DNA damage checkpoint is_a: GO:1902403 ! signal transduction involved in mitotic DNA integrity checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0044773 ! mitotic DNA damage checkpoint relationship: part_of GO:0044773 ! mitotic DNA damage checkpoint created_by: jl creation_date: 2013-09-12T12:07:20Z [Term] id: GO:1902403 name: signal transduction involved in mitotic DNA integrity checkpoint namespace: biological_process def: "Any intracellular signal transduction that is involved in mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in topo II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in topo II checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling cascade involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling cascade involved in topo II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling cascade involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in topo II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in topoisomerase II checkpoint" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in mitotic DNA integrity checkpoint" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in topo II checkpoint" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in mitotic DNA integrity checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in topo II checkpoint" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in mitotic DNA integrity checkpoint" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in topo II checkpoint" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie] is_a: GO:0072401 ! signal transduction involved in DNA integrity checkpoint is_a: GO:0072413 ! signal transduction involved in mitotic cell cycle checkpoint intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0044774 ! mitotic DNA integrity checkpoint relationship: part_of GO:0044774 ! mitotic DNA integrity checkpoint created_by: jl creation_date: 2013-09-12T12:07:28Z [Term] id: GO:1902404 name: mitotic actomyosin contractile ring contraction namespace: biological_process def: "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0000916 ! actomyosin contractile ring contraction is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0000916 ! actomyosin contractile ring contraction intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2013-09-12T12:27:57Z [Term] id: GO:1902405 name: mitotic actomyosin contractile ring localization namespace: biological_process def: "Any actomyosin contractile ring localization that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0032187 ! actomyosin contractile ring localization is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0032187 ! actomyosin contractile ring localization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2013-09-12T12:28:05Z [Term] id: GO:1902406 name: mitotic actomyosin contractile ring maintenance namespace: biological_process def: "Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0031566 ! actomyosin contractile ring maintenance is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0031566 ! actomyosin contractile ring maintenance intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2013-09-12T12:28:14Z [Term] id: GO:1902407 name: assembly of actomyosin apparatus involved in mitotic cytokinesis namespace: biological_process def: "Any assembly of mitotic cytokinetic actomyosin apparatus." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2013-09-12T12:28:22Z [Term] id: GO:1902408 name: mitotic cytokinesis, site selection namespace: biological_process def: "Any cytokinesis, site selection that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "site selection involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "site selection involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0007105 ! cytokinesis, site selection intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2013-09-12T12:29:13Z [Term] id: GO:1902410 name: mitotic cytokinetic process namespace: biological_process def: "Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:0032506 ! cytokinetic process is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0032506 ! cytokinetic process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000281 ! mitotic cytokinesis created_by: jl creation_date: 2013-09-12T12:29:36Z [Term] id: GO:1902412 name: regulation of mitotic cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0032465 ! regulation of cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000281 ! mitotic cytokinesis relationship: regulates GO:0000281 ! mitotic cytokinesis created_by: jl creation_date: 2013-09-12T14:11:49Z [Term] id: GO:1902413 name: negative regulation of mitotic cytokinesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "inhibition of cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "negative regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1902412 ! regulation of mitotic cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000281 ! mitotic cytokinesis relationship: negatively_regulates GO:0000281 ! mitotic cytokinesis created_by: jl creation_date: 2013-09-12T14:11:59Z [Term] id: GO:1902414 name: protein localization to cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie] synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie] synonym: "protein localization in cell junction" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization created_by: tb creation_date: 2013-09-13T16:55:57Z [Term] id: GO:1902415 name: regulation of mRNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] is_a: GO:1905214 ! regulation of RNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003729 ! mRNA binding relationship: regulates GO:0003729 ! mRNA binding created_by: rb creation_date: 2013-09-13T18:57:15Z [Term] id: GO:1902416 name: positive regulation of mRNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] synonym: "activation of mRNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of mRNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA binding" EXACT [GOC:TermGenie] is_a: GO:1902415 ! regulation of mRNA binding is_a: GO:1905216 ! positive regulation of RNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003729 ! mRNA binding relationship: positively_regulates GO:0003729 ! mRNA binding created_by: rb creation_date: 2013-09-13T18:57:24Z [Term] id: GO:1902417 name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other." [GOC:TermGenie, PMID:24028845] synonym: "ABA-GE transmembrane transporter activity" EXACT [] synonym: "abscisic acid glucosyl ester transmembrane transporter activity" EXACT [] is_a: GO:0042947 ! glucoside transmembrane transporter activity relationship: part_of GO:1902418 ! (+)-abscisic acid D-glucopyranosyl ester transmembrane transport created_by: tb creation_date: 2013-09-16T22:37:11Z [Term] id: GO:1902418 name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transport namespace: biological_process def: "The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane." [GOC:TermGenie, PMID:24028845] synonym: "ABA-GE transmembrane transport" EXACT [] synonym: "abscisic acid glucosyl ester transmembrane transport" EXACT [] is_a: GO:0042946 ! glucoside transport is_a: GO:0055085 ! transmembrane transport created_by: tb creation_date: 2013-09-16T22:37:20Z [Term] id: GO:1902421 name: hydrogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761] synonym: "dihydrogen metabolism" EXACT [GOC:TermGenie] synonym: "H2 metabolism" EXACT [] synonym: "molecular hydrogen metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2013-09-18T14:34:23Z [Term] id: GO:1902422 name: hydrogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761] synonym: "dihydrogen synthesis" EXACT [GOC:jl] synonym: "H2 biosynthesis" EXACT [] synonym: "hydrogen anabolism" EXACT [GOC:TermGenie] synonym: "hydrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "hydrogen formation" EXACT [GOC:TermGenie] synonym: "hydrogen generation" EXACT [GOC:jl] synonym: "hydrogen production" EXACT [] synonym: "hydrogen synthesis" EXACT [GOC:TermGenie] synonym: "molecular hydrogen biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:1902421 ! hydrogen metabolic process created_by: jl creation_date: 2013-09-18T14:34:32Z [Term] id: GO:1902423 name: regulation of attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639] synonym: "regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] synonym: "regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT [] synonym: "regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore is_a: GO:0090235 ! regulation of metaphase plate congression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore relationship: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore created_by: vw creation_date: 2013-09-19T10:33:38Z [Term] id: GO:1902424 name: negative regulation of attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639] synonym: "down regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "down regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "down-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "down-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "downregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "downregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "inhibition of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie] synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie] synonym: "inhibition of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "negative regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] synonym: "negative regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT [] synonym: "negative regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:0051986 ! negative regulation of attachment of spindle microtubules to kinetochore is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore relationship: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore created_by: vw creation_date: 2013-09-19T10:33:46Z [Term] id: GO:1902425 name: positive regulation of attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639] synonym: "activation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie] synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie] synonym: "activation of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie] synonym: "activation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "positive regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] synonym: "positive regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore relationship: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore created_by: vw creation_date: 2013-09-19T10:33:55Z [Term] id: GO:1902426 name: deactivation of mitotic spindle assembly checkpoint namespace: biological_process def: "A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:19075002, PMID:19592249] comment: A mitotic spindle assembly checkpoint is either activated or switched off; no other means of reducing the frequency, rate or extent of this process are currently known. synonym: "down regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "down regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "down regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "down-regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "down-regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "down-regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "downregulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "downregulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "downregulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "inhibition of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "inhibition of mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:TermGenie] synonym: "inhibition of mitotic spindle assembly checkpoint" RELATED [GOC:TermGenie] synonym: "mitotic spindle assembly checkpoint silencing" EXACT [] synonym: "mitotic spindle assembly deactivation" EXACT [] synonym: "negative regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] synonym: "negative regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] synonym: "negative regulation of mitotic spindle assembly checkpoint" BROAD [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0090233 ! negative regulation of spindle checkpoint is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint relationship: negatively_regulates GO:0007094 ! mitotic spindle assembly checkpoint created_by: dph creation_date: 2013-09-20T18:42:07Z [Term] id: GO:1902427 name: regulation of water channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752] synonym: "regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "regulation of aquaporin permeability" NARROW [PMID:22095752] is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015250 ! water channel activity relationship: regulates GO:0015250 ! water channel activity created_by: bf creation_date: 2013-09-23T12:56:31Z [Term] id: GO:1902428 name: negative regulation of water channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity." [GOC:TermGenie] synonym: "down regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "down regulation of water channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "down-regulation of water channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of aquaporin" NARROW [GOC:TermGenie] synonym: "downregulation of water channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of aquaporin" NARROW [GOC:TermGenie] synonym: "inhibition of water channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of aquaporin" NARROW [GOC:TermGenie] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:1902427 ! regulation of water channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015250 ! water channel activity relationship: negatively_regulates GO:0015250 ! water channel activity created_by: bf creation_date: 2013-09-23T12:56:40Z [Term] id: GO:1902429 name: positive regulation of water channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752] synonym: "activation of aquaporin" NARROW [GOC:TermGenie] synonym: "activation of water channel activity" NARROW [GOC:TermGenie] synonym: "aquaporin activation" NARROW [PMID:22095752] synonym: "positive regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "up regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "up regulation of water channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aquaporin" NARROW [GOC:TermGenie] synonym: "up-regulation of water channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of aquaporin" NARROW [GOC:TermGenie] synonym: "upregulation of water channel activity" EXACT [GOC:TermGenie] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:1902427 ! regulation of water channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015250 ! water channel activity relationship: positively_regulates GO:0015250 ! water channel activity created_by: bf creation_date: 2013-09-23T12:56:49Z [Term] id: GO:1902430 name: negative regulation of amyloid-beta formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation." [GOC:hjd, GOC:TermGenie, PMID:22992957] synonym: "down regulation of beta-amyloid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-amyloid formation" EXACT [GOC:TermGenie] synonym: "downregulation of beta-amyloid formation" EXACT [GOC:TermGenie] synonym: "inhibition of beta-amyloid formation" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-amyloid formation" EXACT [] is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:1902003 ! regulation of amyloid-beta formation is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034205 ! amyloid-beta formation relationship: negatively_regulates GO:0034205 ! amyloid-beta formation created_by: hjd creation_date: 2013-09-25T17:41:01Z [Term] id: GO:1902432 name: protein localization to division septum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a division septum." [GOC:TermGenie, PMID:9367977] synonym: "protein localisation in division septum" EXACT [GOC:TermGenie] synonym: "protein localisation to division septum" EXACT [GOC:TermGenie] synonym: "protein localization in division septum" EXACT [GOC:TermGenie] is_a: GO:0072741 ! protein localization to cell division site created_by: mah creation_date: 2013-09-30T14:29:51Z [Term] id: GO:1902433 name: positive regulation of water channel activity involved in maintenance of lens transparency namespace: biological_process def: "Any positive regulation of water channel activity that is involved in maintenance of lens transparency." [GOC:nhn, GOC:TermGenie, PMID:22095752] synonym: "activation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "activation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "activation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "activation of water channel activity involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "activation of water channel activity involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "activation of water channel activity involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "aquaporin activation involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "aquaporin activation involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "aquaporin activation involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "positive regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "positive regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "positive regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "positive regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] synonym: "positive regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] synonym: "up regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "up regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "up regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "up regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] synonym: "up regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] synonym: "up regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] synonym: "up-regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "up-regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "up-regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "up-regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] synonym: "up-regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] synonym: "up-regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] synonym: "upregulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] synonym: "upregulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] synonym: "upregulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] synonym: "upregulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] synonym: "upregulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] synonym: "upregulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] is_a: GO:1902429 ! positive regulation of water channel activity intersection_of: GO:1902429 ! positive regulation of water channel activity intersection_of: part_of GO:0036438 ! maintenance of lens transparency relationship: part_of GO:0036438 ! maintenance of lens transparency created_by: bf creation_date: 2013-10-02T12:58:00Z [Term] id: GO:1902434 name: sulfate import across plasma membrane namespace: biological_process def: "The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:TermGenie, PMID:14723223] synonym: "sulfate import into cell" EXACT [] synonym: "sulphate import into cell" EXACT [] is_a: GO:0098658 ! inorganic anion import across plasma membrane is_a: GO:1902358 ! sulfate transmembrane transport created_by: mah creation_date: 2013-10-07T14:12:38Z [Term] id: GO:1902435 name: regulation of male mating behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050795 ! regulation of behavior is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060179 ! male mating behavior relationship: regulates GO:0060179 ! male mating behavior created_by: mm2 creation_date: 2013-10-09T15:49:56Z [Term] id: GO:1902436 name: negative regulation of male mating behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] synonym: "down regulation of male mating behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of male mating behavior" EXACT [GOC:TermGenie] synonym: "downregulation of male mating behavior" EXACT [GOC:TermGenie] synonym: "inhibition of male mating behavior" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902435 ! regulation of male mating behavior is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060179 ! male mating behavior relationship: negatively_regulates GO:0060179 ! male mating behavior created_by: mm2 creation_date: 2013-10-09T15:50:05Z [Term] id: GO:1902437 name: positive regulation of male mating behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] synonym: "activation of male mating behavior" NARROW [GOC:TermGenie] synonym: "up regulation of male mating behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of male mating behavior" EXACT [GOC:TermGenie] synonym: "upregulation of male mating behavior" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902435 ! regulation of male mating behavior is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060179 ! male mating behavior relationship: positively_regulates GO:0060179 ! male mating behavior created_by: mm2 creation_date: 2013-10-09T15:50:14Z [Term] id: GO:1902438 name: response to vanadate(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: di creation_date: 2013-10-10T10:50:21Z [Term] id: GO:1902439 name: cellular response to vanadate(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902438 ! response to vanadate(3-) created_by: di creation_date: 2013-10-10T10:50:30Z [Term] id: GO:1902440 name: protein localization to mitotic spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body." [GOC:TermGenie, PMID:22438582] synonym: "protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle pole body" EXACT [GOC:TermGenie] is_a: GO:0071988 ! protein localization to spindle pole body created_by: mah creation_date: 2013-10-10T14:44:55Z [Term] id: GO:1902441 name: protein localization to meiotic spindle pole body namespace: biological_process alt_id: GO:1990945 def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body." [GOC:mah, GOC:TermGenie, GOC:vw, PMID:20833892, PMID:22438582] synonym: "protein localisation in meiotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localisation to meiotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localization in meiotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein location to meiotic spindle pole body" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0071988 ! protein localization to spindle pole body relationship: part_of GO:1990395 ! meiotic spindle pole body organization created_by: mah creation_date: 2013-10-10T14:45:04Z [Term] id: GO:1902442 name: regulation of ripoptosome assembly involved in necroptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097] synonym: "regulation of ripoptosome assembly involved in necroptosis" NARROW [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0060544 ! regulation of necroptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process relationship: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process created_by: dph creation_date: 2013-10-10T17:51:33Z [Term] id: GO:1902443 name: negative regulation of ripoptosome assembly involved in necroptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097] synonym: "down regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] synonym: "downregulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] synonym: "inhibition of ripoptosome assembly involved in necroptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of ripoptosome assembly involved in necroptosis" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0060546 ! negative regulation of necroptotic process is_a: GO:1902442 ! regulation of ripoptosome assembly involved in necroptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process relationship: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process created_by: dph creation_date: 2013-10-10T17:51:41Z [Term] id: GO:1902444 name: riboflavin binding namespace: molecular_function def: "Interacting selectively and non-covalently with riboflavin." [GOC:TermGenie, PMID:12083520] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0043168 ! anion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: al creation_date: 2013-10-11T08:44:52Z [Term] id: GO:1902445 name: regulation of mitochondrial membrane permeability involved in programmed necrotic cell death namespace: biological_process def: "Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:22493254] synonym: "regulation of transport across mitochondrial membrane involved in programmed necrotic cell death" EXACT [GOC:TermGenie] is_a: GO:0046902 ! regulation of mitochondrial membrane permeability intersection_of: GO:0046902 ! regulation of mitochondrial membrane permeability intersection_of: part_of GO:0097300 ! programmed necrotic cell death relationship: part_of GO:0097300 ! programmed necrotic cell death created_by: dph creation_date: 2013-10-11T13:11:20Z [Term] id: GO:1902446 name: regulation of shade avoidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] is_a: GO:2000030 ! regulation of response to red or far red light intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009641 ! shade avoidance relationship: regulates GO:0009641 ! shade avoidance created_by: dhl creation_date: 2013-10-15T21:04:36Z [Term] id: GO:1902447 name: negative regulation of shade avoidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] synonym: "down regulation of shade avoidance" EXACT [GOC:TermGenie] synonym: "down-regulation of shade avoidance" EXACT [GOC:TermGenie] synonym: "downregulation of shade avoidance" EXACT [GOC:TermGenie] synonym: "inhibition of shade avoidance" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1902446 ! regulation of shade avoidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009641 ! shade avoidance relationship: negatively_regulates GO:0009641 ! shade avoidance created_by: dhl creation_date: 2013-10-15T21:04:51Z [Term] id: GO:1902448 name: positive regulation of shade avoidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] synonym: "activation of shade avoidance" NARROW [GOC:TermGenie] synonym: "up regulation of shade avoidance" EXACT [GOC:TermGenie] synonym: "up-regulation of shade avoidance" EXACT [GOC:TermGenie] synonym: "upregulation of shade avoidance" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1902446 ! regulation of shade avoidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009641 ! shade avoidance relationship: positively_regulates GO:0009641 ! shade avoidance created_by: dhl creation_date: 2013-10-15T21:05:00Z [Term] id: GO:1902455 name: negative regulation of stem cell population maintenance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie] synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019827 ! stem cell population maintenance relationship: negatively_regulates GO:0019827 ! stem cell population maintenance created_by: cjmungall creation_date: 2013-10-16T22:19:17Z [Term] id: GO:1902456 name: regulation of stomatal opening namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] is_a: GO:0010119 ! regulation of stomatal movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990069 ! stomatal opening relationship: regulates GO:1990069 ! stomatal opening created_by: tb creation_date: 2013-10-16T22:25:06Z [Term] id: GO:1902457 name: negative regulation of stomatal opening namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] synonym: "down regulation of stomatal opening" EXACT [GOC:TermGenie] synonym: "down-regulation of stomatal opening" EXACT [GOC:TermGenie] synonym: "downregulation of stomatal opening" EXACT [GOC:TermGenie] synonym: "inhibition of stomatal opening" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1902456 ! regulation of stomatal opening intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990069 ! stomatal opening relationship: negatively_regulates GO:1990069 ! stomatal opening created_by: tb creation_date: 2013-10-16T22:25:22Z [Term] id: GO:1902458 name: positive regulation of stomatal opening namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] synonym: "activation of stomatal opening" NARROW [GOC:TermGenie] synonym: "up regulation of stomatal opening" EXACT [GOC:TermGenie] synonym: "up-regulation of stomatal opening" EXACT [GOC:TermGenie] synonym: "upregulation of stomatal opening" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1902456 ! regulation of stomatal opening intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990069 ! stomatal opening relationship: positively_regulates GO:1990069 ! stomatal opening created_by: tb creation_date: 2013-10-16T22:25:33Z [Term] id: GO:1902459 name: positive regulation of stem cell population maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie] synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019827 ! stem cell population maintenance relationship: positively_regulates GO:0019827 ! stem cell population maintenance created_by: cjmungall creation_date: 2013-10-16T22:27:47Z [Term] id: GO:1902460 name: regulation of mesenchymal stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] synonym: "regulation of MSC proliferation" EXACT [GOC:TermGenie] is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097168 ! mesenchymal stem cell proliferation relationship: regulates GO:0097168 ! mesenchymal stem cell proliferation created_by: pm creation_date: 2013-10-22T10:01:00Z [Term] id: GO:1902461 name: negative regulation of mesenchymal stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] synonym: "down regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of MSC proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of MSC proliferation" EXACT [GOC:TermGenie] is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation relationship: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation created_by: pm creation_date: 2013-10-22T10:01:08Z [Term] id: GO:1902462 name: positive regulation of mesenchymal stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] synonym: "activation of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of MSC proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of MSC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of MSC proliferation" EXACT [GOC:TermGenie] is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation relationship: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation created_by: pm creation_date: 2013-10-22T10:01:17Z [Term] id: GO:1902463 name: protein localization to cell leading edge namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326] synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0034613 ! cellular protein localization created_by: jl creation_date: 2013-10-22T12:36:07Z [Term] id: GO:1902464 name: regulation of histone H3-K27 trimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] is_a: GO:0061085 ! regulation of histone H3-K27 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098532 ! histone H3-K27 trimethylation relationship: regulates GO:0098532 ! histone H3-K27 trimethylation created_by: krc creation_date: 2013-10-22T14:58:55Z [Term] id: GO:1902465 name: negative regulation of histone H3-K27 trimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] synonym: "down regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3-K27 trimethylation" NARROW [GOC:TermGenie] is_a: GO:0061086 ! negative regulation of histone H3-K27 methylation is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098532 ! histone H3-K27 trimethylation relationship: negatively_regulates GO:0098532 ! histone H3-K27 trimethylation created_by: krc creation_date: 2013-10-22T14:59:04Z [Term] id: GO:1902466 name: positive regulation of histone H3-K27 trimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] synonym: "activation of histone H3-K27 trimethylation" NARROW [GOC:TermGenie] synonym: "up regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] is_a: GO:0061087 ! positive regulation of histone H3-K27 methylation is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098532 ! histone H3-K27 trimethylation relationship: positively_regulates GO:0098532 ! histone H3-K27 trimethylation created_by: krc creation_date: 2013-10-22T14:59:19Z [Term] id: GO:1902471 name: regulation of mitotic actomyosin contractile ring localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] is_a: GO:1901648 ! regulation of actomyosin contractile ring localization is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902405 ! mitotic actomyosin contractile ring localization relationship: regulates GO:1902405 ! mitotic actomyosin contractile ring localization created_by: mah creation_date: 2013-10-24T14:20:03Z [Term] id: GO:1902472 name: regulation of mitotic cytokinesis, site selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis, site selection." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] is_a: GO:1903436 ! regulation of mitotic cytokinetic process is_a: GO:2000073 ! regulation of cytokinesis, site selection intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902408 ! mitotic cytokinesis, site selection relationship: regulates GO:1902408 ! mitotic cytokinesis, site selection created_by: mah creation_date: 2013-10-24T14:20:12Z [Term] id: GO:1902473 name: regulation of protein localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035418 ! protein localization to synapse relationship: regulates GO:0035418 ! protein localization to synapse created_by: kmv creation_date: 2013-10-25T15:09:09Z [Term] id: GO:1902474 name: positive regulation of protein localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035418 ! protein localization to synapse relationship: positively_regulates GO:0035418 ! protein localization to synapse created_by: kmv creation_date: 2013-10-25T15:09:18Z [Term] id: GO:1902475 name: L-alpha-amino acid transmembrane transport namespace: biological_process def: "The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015807 ! L-amino acid transport created_by: kmv creation_date: 2013-10-25T15:17:39Z [Term] id: GO:1902476 name: chloride transmembrane transport namespace: biological_process def: "The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw] is_a: GO:0006821 ! chloride transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: bf creation_date: 2013-10-28T09:44:29Z [Term] id: GO:1902477 name: regulation of defense response to bacterium, incompatible interaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885] synonym: "regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:1900424 ! regulation of defense response to bacterium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009816 ! defense response to bacterium, incompatible interaction relationship: regulates GO:0009816 ! defense response to bacterium, incompatible interaction created_by: tb creation_date: 2013-10-30T20:13:13Z [Term] id: GO:1902478 name: negative regulation of defense response to bacterium, incompatible interaction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885] synonym: "down regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "down regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "down regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "down regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "down-regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down-regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down-regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "down-regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "down-regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "down-regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "down-regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "downregulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "downregulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "downregulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "downregulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "downregulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "downregulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "downregulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "inhibition of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "negative regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "negative regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "negative regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "negative regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "negative regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "negative regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "negative regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:1900425 ! negative regulation of defense response to bacterium is_a: GO:1902477 ! regulation of defense response to bacterium, incompatible interaction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction relationship: negatively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction created_by: tb creation_date: 2013-10-30T20:13:22Z [Term] id: GO:1902479 name: positive regulation of defense response to bacterium, incompatible interaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium, incompatible interaction." [GOC:TermGenie, PMID:24134885] synonym: "activation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "activation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] synonym: "activation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "activation of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] synonym: "activation of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "activation of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie] synonym: "positive regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "positive regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "positive regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "positive regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "positive regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "positive regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "positive regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "up regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "up regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "up regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "up regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "up-regulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up-regulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up-regulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "up-regulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "up-regulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "up-regulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "up-regulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "upregulation of defence response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "upregulation of defence response to pathogenic bacteria, incompatible interaction" EXACT [GOC:TermGenie] synonym: "upregulation of defence response to pathogenic bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to bacterium, incompatible interaction" EXACT [GOC:TermGenie] synonym: "upregulation of resistance response to pathogenic bacteria" EXACT [GOC:TermGenie] synonym: "upregulation of resistance response to pathogenic bacterium" EXACT [GOC:TermGenie] synonym: "upregulation of response to pathogenic bacteria (incompatible interaction)" EXACT [GOC:TermGenie] synonym: "upregulation of response to pathogenic bacterium (incompatible interaction)" EXACT [GOC:TermGenie] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:1900426 ! positive regulation of defense response to bacterium is_a: GO:1902477 ! regulation of defense response to bacterium, incompatible interaction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction relationship: positively_regulates GO:0009816 ! defense response to bacterium, incompatible interaction created_by: tb creation_date: 2013-10-30T20:13:31Z [Term] id: GO:1902480 name: protein localization to mitotic spindle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle." [GOC:TermGenie, PMID:23885124] synonym: "protein localisation in mitotic spindle" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle" EXACT [GOC:TermGenie] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton created_by: mah creation_date: 2013-11-04T13:16:47Z [Term] id: GO:1902481 name: gamma-tubulin complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex." [GOC:TermGenie, PMID:23885124] synonym: "gamma-tubulin complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2013-11-04T13:21:12Z [Term] id: GO:1902482 name: regulatory T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a regulatory T cell." [GOC:nhn, GOC:TermGenie, PUBMED:20471291] synonym: "regulatory T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulatory T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulatory T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulatory T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process created_by: Nevila.Nouspikel creation_date: 2013-11-04T17:18:09Z [Term] id: GO:1902483 name: cytotoxic T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a cytotoxic T cell." [GOC:nhn, GOC:TermGenie, PUBMED:19604492] synonym: "cytotoxic T cell apoptosis" NARROW [GOC:TermGenie] synonym: "cytotoxic T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "cytotoxic T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "cytotoxic T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "cytotoxic T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "cytotoxic T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "cytotoxic T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process created_by: Nevila.Nouspikel creation_date: 2013-11-04T17:23:48Z [Term] id: GO:1902484 name: Sertoli cell apoptotic process namespace: biological_process def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895] synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: pr creation_date: 2013-11-06T11:27:34Z [Term] id: GO:1902485 name: L-cysteine binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-cysteine." [GOC:bhm, GOC:TermGenie, PMID:12941942] is_a: GO:0016597 ! amino acid binding is_a: GO:0043169 ! cation binding is_a: GO:1901681 ! sulfur compound binding created_by: bhm creation_date: 2013-11-12T09:06:28Z [Term] id: GO:1902486 name: protein localization to growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a growing cell tip." [GOC:TermGenie, PMID:23041194] synonym: "protein localisation in growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1990151 ! protein localization to cell tip created_by: mah creation_date: 2013-11-12T16:38:13Z [Term] id: GO:1902487 name: protein localization to non-growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip." [GOC:TermGenie, PMID:21652630, PMID:23041194] synonym: "protein localisation in non-growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to non-growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in non-growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1990151 ! protein localization to cell tip created_by: mah creation_date: 2013-11-12T16:38:22Z [Term] id: GO:1902488 name: cholangiocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800] synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: cynthia.smith creation_date: 2013-11-12T15:30:08Z [Term] id: GO:1902489 name: hepatoblast apoptotic process namespace: biological_process def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967] synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process created_by: cynthia.smith creation_date: 2013-11-12T17:02:52Z [Term] id: GO:1902490 name: regulation of sperm capacitation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "regulation of sperm activation" RELATED [GOC:TermGenie] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:1903429 ! regulation of cell maturation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048240 ! sperm capacitation relationship: regulates GO:0048240 ! sperm capacitation created_by: hjd creation_date: 2013-11-12T21:17:03Z [Term] id: GO:1902491 name: negative regulation of sperm capacitation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie] synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie] synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie] synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902490 ! regulation of sperm capacitation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048240 ! sperm capacitation relationship: negatively_regulates GO:0048240 ! sperm capacitation created_by: hjd creation_date: 2013-11-12T21:17:12Z [Term] id: GO:1902492 name: positive regulation of sperm capacitation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] synonym: "activation of sperm activation" RELATED [GOC:TermGenie] synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie] synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie] synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie] synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie] synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902490 ! regulation of sperm capacitation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048240 ! sperm capacitation relationship: positively_regulates GO:0048240 ! sperm capacitation created_by: hjd creation_date: 2013-11-12T21:17:21Z [Term] id: GO:1902493 name: acetyltransferase complex namespace: cellular_component def: "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] is_a: GO:1990234 ! transferase complex created_by: bhm creation_date: 2013-11-13T16:16:45Z [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] subset: goslim_metagenomics synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1902495 name: transmembrane transporter complex namespace: cellular_component def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990351 ! transporter complex relationship: part_of GO:0016021 ! integral component of membrane created_by: bhm creation_date: 2013-11-13T16:23:04Z [Term] id: GO:1902496 name: obsolete protein binding involved in negative regulation of telomere maintenance via telomerase namespace: molecular_function def: "OBSOLETE. Any protein binding that is involved in negative regulation of telomere maintenance via telomerase." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:24013504] comment: The reason for obsoletion is that this should be captured as a GO-CAM model. synonym: "protein binding involved in down regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] synonym: "protein binding involved in down-regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] synonym: "protein binding involved in downregulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] synonym: "protein binding involved in inhibition of telomere maintenance via telomerase" NARROW [GOC:TermGenie] is_obsolete: true created_by: dph creation_date: 2013-11-13T16:22:49Z [Term] id: GO:1902497 name: iron-sulfur cluster transport namespace: biological_process def: "The directed movement of an iron-sulfur cluster into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706] is_a: GO:0051181 ! cofactor transport is_a: GO:1901678 ! iron coordination entity transport created_by: dph creation_date: 2013-11-13T16:33:00Z [Term] id: GO:1902498 name: regulation of protein autoubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405] synonym: "regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] is_a: GO:0031396 ! regulation of protein ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051865 ! protein autoubiquitination relationship: regulates GO:0051865 ! protein autoubiquitination created_by: rb creation_date: 2013-11-13T21:03:28Z [Term] id: GO:1902499 name: positive regulation of protein autoubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405] synonym: "activation of protein auto-ubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein auto-ubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of protein autoubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein autoubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of protein self-ubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein self-ubiquitinylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "positive regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "positive regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:1902498 ! regulation of protein autoubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051865 ! protein autoubiquitination relationship: positively_regulates GO:0051865 ! protein autoubiquitination created_by: rb creation_date: 2013-11-13T21:03:37Z [Term] id: GO:1902500 name: vacuolar HOPS complex namespace: cellular_component def: "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161] synonym: "vacuolar membrane HOPS complex" EXACT [] is_a: GO:0030897 ! HOPS complex intersection_of: GO:0030897 ! HOPS complex intersection_of: part_of GO:0005774 ! vacuolar membrane relationship: part_of GO:0005774 ! vacuolar membrane created_by: tb creation_date: 2013-11-14T00:09:50Z [Term] id: GO:1902501 name: lysosomal HOPS complex namespace: cellular_component def: "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161] synonym: "lysosomal membrane HOPS complex" EXACT [] is_a: GO:1902500 ! vacuolar HOPS complex intersection_of: GO:0030897 ! HOPS complex intersection_of: part_of GO:0005765 ! lysosomal membrane relationship: part_of GO:0005765 ! lysosomal membrane created_by: tb creation_date: 2013-11-14T00:09:59Z [Term] id: GO:1902502 name: multivesicular body HOPS complex namespace: cellular_component def: "Any HOPS complex that is part of a multivesicular body membrane." [GOC:TermGenie, PMID:23645161] synonym: "multivesicular body membrane HOPS complex" EXACT [] is_a: GO:0030897 ! HOPS complex intersection_of: GO:0030897 ! HOPS complex intersection_of: part_of GO:0032585 ! multivesicular body membrane relationship: part_of GO:0032585 ! multivesicular body membrane created_by: tb creation_date: 2013-11-14T00:10:08Z [Term] id: GO:1902503 name: adenylyltransferase complex namespace: cellular_component def: "A protein complex which is capable of adenylyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:11713534] synonym: "ThiF-ThiS complex" RELATED [GOC:dph] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: bhm creation_date: 2013-11-14T10:37:25Z [Term] id: GO:1902504 name: regulation of signal transduction involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494] synonym: "regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1902531 ! regulation of intracellular signal transduction is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint relationship: regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint created_by: vw creation_date: 2013-11-14T15:26:46Z [Term] id: GO:1902505 name: negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494] synonym: "down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "inhibition of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle is_a: GO:1902504 ! regulation of signal transduction involved in mitotic G2 DNA damage checkpoint is_a: GO:1902532 ! negative regulation of intracellular signal transduction is_a: GO:1904290 ! negative regulation of mitotic DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint relationship: negatively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint created_by: vw creation_date: 2013-11-14T15:26:55Z [Term] id: GO:1902506 name: positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction involved in mitotic G2 DNA damage checkpoint." [GOC:TermGenie, PMID:16299494] synonym: "activation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "activation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:1902504 ! regulation of signal transduction involved in mitotic G2 DNA damage checkpoint is_a: GO:1902533 ! positive regulation of intracellular signal transduction is_a: GO:1904291 ! positive regulation of mitotic DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint relationship: positively_regulates GO:0072434 ! signal transduction involved in mitotic G2 DNA damage checkpoint created_by: vw creation_date: 2013-11-14T15:27:04Z [Term] id: GO:1902507 name: thiazole synthase complex namespace: cellular_component def: "A protein complex which is capable of thiazole synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933] is_a: GO:1990228 ! sulfurtransferase complex created_by: bhm creation_date: 2013-11-14T16:19:28Z [Term] id: GO:1902508 name: 2-iminoacetate synthase complex namespace: cellular_component def: "A protein complex which is capable of 2-iminoacetate synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933] synonym: "ThiH-ThiG complex" NARROW [GOC:bhm, GOC:dph] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2013-11-14T16:56:44Z [Term] id: GO:1902509 name: methionine-importing complex namespace: cellular_component def: "A protein complex which is capable of methionine-importing activity." [GOC:pr, GOC:TermGenie, PMID:23748165] synonym: "methionine importer complex" EXACT [] synonym: "methionine importing complex" EXACT [] is_a: GO:1902495 ! transmembrane transporter complex created_by: pr creation_date: 2013-11-15T10:42:41Z [Term] id: GO:1902510 name: regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie] synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie] synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1900117 ! regulation of execution phase of apoptosis is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006309 ! apoptotic DNA fragmentation relationship: regulates GO:0006309 ! apoptotic DNA fragmentation created_by: hjd creation_date: 2013-11-15T18:28:32Z [Term] id: GO:1902511 name: negative regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1900118 ! negative regulation of execution phase of apoptosis is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903625 ! negative regulation of DNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation relationship: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation created_by: hjd creation_date: 2013-11-15T18:28:41Z [Term] id: GO:1902512 name: positive regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1900119 ! positive regulation of execution phase of apoptosis is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903626 ! positive regulation of DNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006309 ! apoptotic DNA fragmentation relationship: positively_regulates GO:0006309 ! apoptotic DNA fragmentation created_by: hjd creation_date: 2013-11-15T18:28:50Z [Term] id: GO:1902513 name: regulation of organelle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087] synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072384 ! organelle transport along microtubule relationship: regulates GO:0072384 ! organelle transport along microtubule created_by: dph creation_date: 2013-11-15T20:15:17Z [Term] id: GO:1902514 name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel namespace: biological_process def: "Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel." [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048] synonym: "regulation of generation of L-type calcium current" RELATED [] is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel relationship: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel created_by: dph creation_date: 2013-11-16T00:04:42Z [Term] id: GO:1902515 name: thioredoxin-disulfide reductase complex namespace: cellular_component def: "A protein complex which is capable of thioredoxin-disulfide reductase activity." [GOC:bhm, GOC:TermGenie, PMID:10947986] comment: An example of this is thioredoxin reductase (TrxB) in E. coli [P0A9P4] in PMID:10947986. is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2013-11-26T11:43:38Z [Term] id: GO:1902516 name: sn-glycerol 3-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with sn-glycerol 3-phosphate." [GOC:bhm, GOC:TermGenie, PMID:23013274] comment: An example of this is UgpB in E. coli [P0AG80] - see PMID:23013274. is_a: GO:0043168 ! anion binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: bhm creation_date: 2013-11-27T16:50:55Z [Term] id: GO:1902517 name: glycerol-3-phosphate-transporting ATPase complex namespace: cellular_component def: "A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity." [GOC:bhm, GOC:TermGenie, PMID:23013274] comment: An example of this is UgpB in E. coli in PMID:23013274. is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex created_by: bhm creation_date: 2013-11-27T16:53:33Z [Term] id: GO:1902518 name: response to cyclophosphamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0097327 ! response to antineoplastic agent created_by: dw creation_date: 2013-12-02T09:34:08Z [Term] id: GO:1902519 name: response to docetaxel trihydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to docetaxel" RELATED [] is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2013-12-02T09:44:04Z [Term] id: GO:1902520 name: response to doxorubicin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0060359 ! response to ammonium ion is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone is_a: GO:1903416 ! response to glycoside created_by: dw creation_date: 2013-12-02T09:44:13Z [Term] id: GO:1902521 name: response to etoposide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1904631 ! response to glucoside created_by: dw creation_date: 2013-12-02T09:44:22Z [Term] id: GO:1902522 name: response to 4'-epidoxorubicin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to epirubicin" RELATED [] is_a: GO:0046677 ! response to antibiotic is_a: GO:0060359 ! response to ammonium ion is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone is_a: GO:1903416 ! response to glycoside created_by: dw creation_date: 2013-12-02T09:44:31Z [Term] id: GO:1902523 name: positive regulation of protein K63-linked ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie, PMID:21931591] comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. synonym: "activation of protein K63-linked polyubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein K63-linked ubiquitination" NARROW [GOC:TermGenie] synonym: "positive regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination is_a: GO:1902916 ! positive regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070534 ! protein K63-linked ubiquitination relationship: positively_regulates GO:0070534 ! protein K63-linked ubiquitination created_by: ppm creation_date: 2013-12-02T09:52:05Z [Term] id: GO:1902524 name: positive regulation of protein K48-linked ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination." [GOC:TermGenie, PMID:21931591] comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. synonym: "activation of protein K48-linked polyubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein K48-linked ubiquitination" NARROW [GOC:TermGenie] synonym: "positive regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination is_a: GO:1902916 ! positive regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070936 ! protein K48-linked ubiquitination relationship: positively_regulates GO:0070936 ! protein K48-linked ubiquitination created_by: ppm creation_date: 2013-12-02T09:56:40Z [Term] id: GO:1902525 name: regulation of protein monoubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] synonym: "regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031396 ! regulation of protein ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006513 ! protein monoubiquitination relationship: regulates GO:0006513 ! protein monoubiquitination created_by: ppm creation_date: 2013-12-02T09:58:56Z [Term] id: GO:1902526 name: negative regulation of protein monoubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] synonym: "down regulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein monoubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of protein monoubiquitinylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein monoubiquitylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:1902525 ! regulation of protein monoubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006513 ! protein monoubiquitination relationship: negatively_regulates GO:0006513 ! protein monoubiquitination created_by: ppm creation_date: 2013-12-02T09:59:05Z [Term] id: GO:1902527 name: positive regulation of protein monoubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. synonym: "activation of protein monoubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein monoubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of protein monoubiquitylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein monoubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein monoubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:1902525 ! regulation of protein monoubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006513 ! protein monoubiquitination relationship: positively_regulates GO:0006513 ! protein monoubiquitination created_by: ppm creation_date: 2013-12-02T09:59:21Z [Term] id: GO:1902528 name: regulation of protein linear polyubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] synonym: "regulation of M1 linkage" NARROW [GOC:TermGenie] is_a: GO:1902914 ! regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097039 ! protein linear polyubiquitination relationship: regulates GO:0097039 ! protein linear polyubiquitination created_by: ppm creation_date: 2013-12-02T10:03:00Z [Term] id: GO:1902529 name: negative regulation of protein linear polyubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] synonym: "down regulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "down regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "down-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "downregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] synonym: "inhibition of M1 linkage" NARROW [GOC:TermGenie] synonym: "inhibition of protein linear polyubiquitination" NARROW [GOC:TermGenie] synonym: "negative regulation of M1 linkage" NARROW [GOC:TermGenie] is_a: GO:1902528 ! regulation of protein linear polyubiquitination is_a: GO:1902915 ! negative regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097039 ! protein linear polyubiquitination relationship: negatively_regulates GO:0097039 ! protein linear polyubiquitination created_by: ppm creation_date: 2013-12-02T10:03:09Z [Term] id: GO:1902530 name: positive regulation of protein linear polyubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. synonym: "activation of M1 linkage" NARROW [GOC:TermGenie] synonym: "activation of protein linear polyubiquitination" NARROW [GOC:TermGenie] synonym: "positive regulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "up regulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "up regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "up-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of M1 linkage" NARROW [GOC:TermGenie] synonym: "upregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] is_a: GO:1902528 ! regulation of protein linear polyubiquitination is_a: GO:1902916 ! positive regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097039 ! protein linear polyubiquitination relationship: positively_regulates GO:0097039 ! protein linear polyubiquitination created_by: ppm creation_date: 2013-12-02T10:03:18Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010627 def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035556 ! intracellular signal transduction relationship: regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010741 def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035556 ! intracellular signal transduction relationship: negatively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010740 def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035556 ! intracellular signal transduction relationship: positively_regulates GO:0035556 ! intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902535 name: multi-organism membrane invagination namespace: biological_process def: "A membrane invagination which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0010324 ! membrane invagination is_a: GO:0044803 ! multi-organism membrane organization created_by: jl creation_date: 2013-12-02T13:58:43Z [Term] id: GO:1902537 name: obsolete multi-organism pinocytosis namespace: biological_process def: "OBSOLETE. A pinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] comment: This term was obsoleted because there is no evidence that this process exists. is_obsolete: true created_by: jl creation_date: 2013-12-02T14:14:46Z [Term] id: GO:1902539 name: multi-organism macropinocytosis namespace: biological_process def: "A macropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0044351 ! macropinocytosis is_a: GO:0044766 ! multi-organism transport created_by: jl creation_date: 2013-12-02T14:23:06Z [Term] id: GO:1902541 name: multi-organism micropinocytosis namespace: biological_process def: "A micropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0044350 ! micropinocytosis is_a: GO:0044766 ! multi-organism transport created_by: bf creation_date: 2013-12-02T14:26:39Z [Term] id: GO:1902542 name: regulation of protein localization to mitotic spindle pole body namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626] synonym: "regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] is_a: GO:1902363 ! regulation of protein localization to spindle pole body intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902440 ! protein localization to mitotic spindle pole body relationship: regulates GO:1902440 ! protein localization to mitotic spindle pole body created_by: al creation_date: 2013-12-04T13:47:09Z [Term] id: GO:1902543 name: negative regulation of protein localization to mitotic spindle pole body namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626] synonym: "down regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to mitotic spindle pole body" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to mitotic spindle pole body" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body is_a: GO:1902542 ! regulation of protein localization to mitotic spindle pole body intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body relationship: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body created_by: al creation_date: 2013-12-04T13:47:18Z [Term] id: GO:1902544 name: regulation of DNA N-glycosylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] synonym: "regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019104 ! DNA N-glycosylase activity relationship: regulates GO:0019104 ! DNA N-glycosylase activity created_by: rph creation_date: 2013-12-04T14:17:54Z [Term] id: GO:1902545 name: negative regulation of DNA N-glycosylase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] synonym: "down regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "downregulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "inhibition of DNA glycosylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DNA N-glycosylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:1902544 ! regulation of DNA N-glycosylase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019104 ! DNA N-glycosylase activity relationship: negatively_regulates GO:0019104 ! DNA N-glycosylase activity created_by: rph creation_date: 2013-12-04T14:18:03Z [Term] id: GO:1902546 name: positive regulation of DNA N-glycosylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] synonym: "activation of DNA glycosylase activity" NARROW [GOC:TermGenie] synonym: "activation of DNA N-glycosylase activity" NARROW [GOC:TermGenie] synonym: "activation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "positive regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "up regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "up-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] synonym: "upregulation of DNA glycosylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of endonuclease VIII activity" RELATED [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1902544 ! regulation of DNA N-glycosylase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019104 ! DNA N-glycosylase activity relationship: positively_regulates GO:0019104 ! DNA N-glycosylase activity created_by: rph creation_date: 2013-12-04T14:18:12Z [Term] id: GO:1902547 name: regulation of cellular response to vascular endothelial growth factor stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370] synonym: "regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "regulation of cellular response to VEGF" EXACT [GOC:TermGenie] synonym: "regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus relationship: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus created_by: rl creation_date: 2013-12-04T15:14:54Z [Term] id: GO:1902548 name: negative regulation of cellular response to vascular endothelial growth factor stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370] comment: ADAMTS12 (UniProt ID P58397) in human in PMID:17895370 inhibits the formation of VEGF-induced tubular structures in BAE-1 cells (endothelial cell line). synonym: "down regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to VEGF" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "down regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to VEGF" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] synonym: "downregulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to VEGF" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "downregulation of cellular response to VEGFB" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to vascular endothelial growth factor" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to vascular endothelial growth factor stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to VEGF" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to VEGFB" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to VEGF" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus relationship: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus created_by: rl creation_date: 2013-12-04T15:15:03Z [Term] id: GO:1902549 name: protein localization to Mei2 nuclear dot namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot." [GOC:TermGenie, PMID:23980030] synonym: "protein localisation in Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localisation to Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localization in Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localization to Mei2 dot" EXACT [] is_a: GO:0034504 ! protein localization to nucleus created_by: mah creation_date: 2013-12-04T16:17:06Z [Term] id: GO:1902550 name: lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis namespace: biological_process def: "Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis." [GOC:cvs, GOC:TermGenie, PMID:22342843] synonym: "lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0097535 ! lymphoid lineage cell migration into thymus intersection_of: GO:0097535 ! lymphoid lineage cell migration into thymus intersection_of: part_of GO:0097536 ! thymus epithelium morphogenesis relationship: part_of GO:0097536 ! thymus epithelium morphogenesis created_by: pr creation_date: 2013-12-04T21:13:33Z [Term] id: GO:1902551 name: regulation of catalase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] synonym: "regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "regulation of CAT" RELATED [GOC:TermGenie] synonym: "regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "regulation of optidase activity" EXACT [GOC:TermGenie] is_a: GO:2000468 ! regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004096 ! catalase activity relationship: regulates GO:0004096 ! catalase activity created_by: tb creation_date: 2013-12-04T21:55:46Z [Term] id: GO:1902552 name: negative regulation of catalase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] synonym: "down regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "down regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CAT" RELATED [GOC:TermGenie] synonym: "down regulation of catalase activity" EXACT [GOC:TermGenie] synonym: "down regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "down regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "down regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "down regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "down regulation of optidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CAT" RELATED [GOC:TermGenie] synonym: "down-regulation of catalase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "down-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of optidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "downregulation of caperase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CAT" RELATED [GOC:TermGenie] synonym: "downregulation of catalase activity" EXACT [GOC:TermGenie] synonym: "downregulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "downregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of equilase activity" EXACT [GOC:TermGenie] synonym: "downregulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "downregulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "downregulation of optidase activity" EXACT [GOC:TermGenie] synonym: "inhibition of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of caperase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CAT" RELATED [GOC:TermGenie] synonym: "inhibition of catalase activity" NARROW [GOC:TermGenie] synonym: "inhibition of catalase reaction" NARROW [GOC:TermGenie] synonym: "inhibition of catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of equilase activity" NARROW [GOC:TermGenie] synonym: "inhibition of haem catalase activity" NARROW [GOC:TermGenie] synonym: "inhibition of heme catalase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "inhibition of optidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CAT" RELATED [GOC:TermGenie] synonym: "negative regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "negative regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of optidase activity" EXACT [GOC:TermGenie] is_a: GO:1902551 ! regulation of catalase activity is_a: GO:2000469 ! negative regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004096 ! catalase activity relationship: negatively_regulates GO:0004096 ! catalase activity created_by: tb creation_date: 2013-12-04T21:55:55Z [Term] id: GO:1902553 name: positive regulation of catalase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] synonym: "activation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of caperase activity" NARROW [GOC:TermGenie] synonym: "activation of CAT" RELATED [GOC:TermGenie] synonym: "activation of catalase activity" NARROW [GOC:TermGenie] synonym: "activation of catalase reaction" NARROW [GOC:TermGenie] synonym: "activation of catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of equilase activity" NARROW [GOC:TermGenie] synonym: "activation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "activation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "activation of optidase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CAT" RELATED [GOC:TermGenie] synonym: "positive regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "positive regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of optidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "up regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CAT" RELATED [GOC:TermGenie] synonym: "up regulation of catalase activity" EXACT [GOC:TermGenie] synonym: "up regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "up regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "up regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "up regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "up regulation of optidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of caperase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CAT" RELATED [GOC:TermGenie] synonym: "up-regulation of catalase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "up-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of equilase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of optidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] synonym: "upregulation of caperase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CAT" RELATED [GOC:TermGenie] synonym: "upregulation of catalase activity" EXACT [GOC:TermGenie] synonym: "upregulation of catalase reaction" EXACT [GOC:TermGenie] synonym: "upregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of equilase activity" EXACT [GOC:TermGenie] synonym: "upregulation of haem catalase activity" NARROW [GOC:TermGenie] synonym: "upregulation of heme catalase activity" NARROW [GOC:TermGenie] synonym: "upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of manganese catalase activity" NARROW [GOC:TermGenie] synonym: "upregulation of optidase activity" EXACT [GOC:TermGenie] is_a: GO:1902551 ! regulation of catalase activity is_a: GO:2000470 ! positive regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004096 ! catalase activity relationship: positively_regulates GO:0004096 ! catalase activity created_by: tb creation_date: 2013-12-04T21:56:03Z [Term] id: GO:1902554 name: serine/threonine protein kinase complex namespace: cellular_component def: "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). synonym: "PDR16 complex dimer" RELATED [] synonym: "PDR16 complex homodimer" RELATED [] is_a: GO:1902911 ! protein kinase complex created_by: bhm creation_date: 2013-12-06T16:06:12Z [Term] id: GO:1902555 name: endoribonuclease complex namespace: cellular_component def: "A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). synonym: "Ire1 complex dimer" RELATED [] synonym: "Ire1 complex homodimer" RELATED [] synonym: "Ire1 complex homooligomer" RELATED [] is_a: GO:1905348 ! endonuclease complex created_by: bhm creation_date: 2013-12-06T16:09:31Z [Term] id: GO:1902556 name: phosphatidylinositol transporter complex namespace: cellular_component def: "A protein complex which is capable of phosphatidylinositol transporter activity." [GOC:bhm, GOC:TermGenie, PMID:9890948] comment: An example is PDR16 in S. cerevisiae (UniProt ID P53860) in PMID:9890948 (inferred from direct assay). synonym: "Ire1 complex dimer" RELATED [] synonym: "Ire1 complex homodimer" RELATED [] synonym: "Ire1 complex homooligomer" RELATED [] is_a: GO:1990351 ! transporter complex created_by: bhm creation_date: 2013-12-06T16:12:25Z [Term] id: GO:1902557 name: 5'-adenylyl sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other." [GOC:TermGenie, PMID:24296033] comment: An example of this is the YPR011C gene product in S. cerevisiae in PMID:24296033. is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902558 ! 5'-adenylyl sulfate transmembrane transport created_by: mcc creation_date: 2013-12-09T23:08:05Z [Term] id: GO:1902558 name: 5'-adenylyl sulfate transmembrane transport namespace: biological_process def: "The process in which 5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033] synonym: "adenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:0072348 ! sulfur compound transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: mcc creation_date: 2013-12-09T23:16:01Z [Term] id: GO:1902559 name: 3'-phospho-5'-adenylyl sulfate transmembrane transport namespace: biological_process def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033] synonym: "3'-phosphoadenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033] is_a: GO:0046963 ! 3'-phosphoadenosine 5'-phosphosulfate transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: mcc creation_date: 2013-12-09T23:19:04Z [Term] id: GO:1902560 name: GMP reductase complex namespace: cellular_component def: "An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+)." [GOC:bhm, GOC:TermGenie, PMID:12009299] comment: An example of this is GMPR2 in human (UniProt Symbol Q9P2T1) in PMID:12009299 (inferred from direct assay). synonym: "GMP reductase" NARROW [] synonym: "GMPR1 complex" NARROW [] synonym: "GMPR2 complex" NARROW [] synonym: "guanosine monophosphate reductase" NARROW [] is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2013-12-10T11:54:30Z [Term] id: GO:1902561 name: origin recognition complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex." [GOC:TermGenie, PMID:11717425] synonym: "ORC assembly" EXACT [GOC:TermGenie] synonym: "ORC formation" EXACT [GOC:TermGenie] synonym: "origin of replication recognition complex assembly" EXACT [GOC:TermGenie] synonym: "origin of replication recognition complex formation" EXACT [GOC:TermGenie] synonym: "origin recognition complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2013-12-10T12:11:50Z [Term] id: GO:1902562 name: H4 histone acetyltransferase complex namespace: cellular_component def: "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] comment: An example of this is Hpa2 in yeast [Q06592] in PMID:23775086 [IDA]. synonym: "Hpa3 (homo-)dimer" NARROW [PMID:23775086] synonym: "Hpa3 complex" NARROW [PMID:23775086] is_a: GO:0000123 ! histone acetyltransferase complex created_by: bhm creation_date: 2013-12-10T14:43:51Z [Term] id: GO:1902563 name: regulation of neutrophil activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042119 ! neutrophil activation relationship: regulates GO:0042119 ! neutrophil activation created_by: ecu creation_date: 2013-12-10T15:33:08Z [Term] id: GO:1902564 name: negative regulation of neutrophil activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] synonym: "down regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "down-regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "downregulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "inhibition of neutrophil activation" NARROW [GOC:TermGenie] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:1902563 ! regulation of neutrophil activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042119 ! neutrophil activation relationship: negatively_regulates GO:0042119 ! neutrophil activation created_by: ecu creation_date: 2013-12-10T15:33:16Z [Term] id: GO:1902565 name: positive regulation of neutrophil activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] synonym: "activation of neutrophil activation" NARROW [GOC:TermGenie] synonym: "up regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "up-regulation of neutrophil activation" EXACT [GOC:TermGenie] synonym: "upregulation of neutrophil activation" EXACT [GOC:TermGenie] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:1902563 ! regulation of neutrophil activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042119 ! neutrophil activation relationship: positively_regulates GO:0042119 ! neutrophil activation created_by: ecu creation_date: 2013-12-10T15:33:26Z [Term] id: GO:1902566 name: regulation of eosinophil activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043307 ! eosinophil activation relationship: regulates GO:0043307 ! eosinophil activation created_by: ecu creation_date: 2013-12-10T15:54:35Z [Term] id: GO:1902567 name: negative regulation of eosinophil activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] synonym: "down regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "down-regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "downregulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "inhibition of eosinophil activation" NARROW [GOC:TermGenie] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:1902566 ! regulation of eosinophil activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043307 ! eosinophil activation relationship: negatively_regulates GO:0043307 ! eosinophil activation created_by: ecu creation_date: 2013-12-10T15:54:43Z [Term] id: GO:1902568 name: positive regulation of eosinophil activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] synonym: "activation of eosinophil activation" NARROW [GOC:TermGenie] synonym: "up regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "up-regulation of eosinophil activation" EXACT [GOC:TermGenie] synonym: "upregulation of eosinophil activation" EXACT [GOC:TermGenie] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:1902566 ! regulation of eosinophil activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043307 ! eosinophil activation relationship: positively_regulates GO:0043307 ! eosinophil activation created_by: ecu creation_date: 2013-12-10T15:54:52Z [Term] id: GO:1902569 name: negative regulation of activation of Janus kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity." [GOC:TermGenie, PMID:16254138] synonym: "down regulation of activation of JAK1 kinase activity" NARROW [] synonym: "down regulation of activation of JAK1 protein" NARROW [] synonym: "down regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] synonym: "down regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] synonym: "down regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] synonym: "down-regulation of activation of JAK1 kinase activity" NARROW [] synonym: "down-regulation of activation of JAK1 protein" NARROW [] synonym: "down-regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] synonym: "down-regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] synonym: "down-regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:TermGenie] synonym: "downregulation of activation of JAK1 kinase activity" NARROW [] synonym: "downregulation of activation of JAK1 protein" NARROW [] synonym: "downregulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of tyrosine phosphorylation of JAK1 protein" NARROW [] synonym: "downregulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] synonym: "inhibition of activation of JAK1 kinase activity" NARROW [] synonym: "inhibition of activation of JAK1 protein" NARROW [] synonym: "inhibition of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of activation of JAK2 protein" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine phosphorylation of JAK1 protein" NARROW [] synonym: "inhibition of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] synonym: "negative regulation of activation of JAK1 protein" NARROW [] synonym: "negative regulation of activation of JAK2 kinase activity" NARROW [] synonym: "negative regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] synonym: "negative regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] synonym: "negative regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] is_a: GO:0010533 ! regulation of activation of Janus kinase activity is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042976 ! activation of Janus kinase activity relationship: negatively_regulates GO:0042976 ! activation of Janus kinase activity created_by: ecu creation_date: 2013-12-10T16:13:20Z [Term] id: GO:1902570 name: protein localization to nucleolus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus created_by: mah creation_date: 2013-12-10T16:25:28Z [Term] id: GO:1902571 name: regulation of serine-type peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] synonym: "regulation of serine protease activity" NARROW [GOC:TermGenie] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008236 ! serine-type peptidase activity relationship: regulates GO:0008236 ! serine-type peptidase activity created_by: krc creation_date: 2013-12-10T18:16:58Z [Term] id: GO:1902572 name: negative regulation of serine-type peptidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] synonym: "down regulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "down regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "down-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "downregulation of serine-type peptidase activity" EXACT [GOC:TermGenie] synonym: "inhibition of serine protease activity" NARROW [GOC:TermGenie] synonym: "inhibition of serine-type peptidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of serine protease activity" NARROW [GOC:TermGenie] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:1902571 ! regulation of serine-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008236 ! serine-type peptidase activity relationship: negatively_regulates GO:0008236 ! serine-type peptidase activity created_by: krc creation_date: 2013-12-10T18:17:07Z [Term] id: GO:1902573 name: positive regulation of serine-type peptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] synonym: "activation of serine protease activity" NARROW [GOC:TermGenie] synonym: "activation of serine-type peptidase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "up regulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "up regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "up-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of serine protease activity" NARROW [GOC:TermGenie] synonym: "upregulation of serine-type peptidase activity" EXACT [GOC:TermGenie] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:1902571 ! regulation of serine-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008236 ! serine-type peptidase activity relationship: positively_regulates GO:0008236 ! serine-type peptidase activity created_by: krc creation_date: 2013-12-10T18:17:16Z [Term] id: GO:1902574 name: obsolete negative regulation of leucine import by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of leucine import." [GOC:TermGenie, PMID:22992726] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: al creation_date: 2013-12-11T09:43:23Z [Term] id: GO:1902575 name: protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly." [GOC:al, GOC:TermGenie, PMID:24127216] synonym: "protein localisation to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie] synonym: "protein localisation to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie] synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] synonym: "protein localisation to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] synonym: "protein localization to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie] synonym: "protein localization to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie] synonym: "protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] synonym: "protein localization to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] is_a: GO:0072741 ! protein localization to cell division site intersection_of: GO:0072741 ! protein localization to cell division site intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly relationship: part_of GO:0000915 ! actomyosin contractile ring assembly created_by: bf creation_date: 2013-12-16T10:42:25Z [Term] id: GO:1902576 name: negative regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication." [GOC:TermGenie, PMID:19033384] synonym: "down regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "inhibition of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S phase" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S-phase" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033260 ! nuclear DNA replication relationship: negatively_regulates GO:0033260 ! nuclear DNA replication created_by: mah creation_date: 2013-12-17T14:03:02Z [Term] id: GO:1902577 name: protein localization to medial cortical node namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a medial cortical node." [GOC:TermGenie, PMID:24127216] synonym: "protein localisation in medial cortical node" EXACT [GOC:TermGenie] synonym: "protein localisation to medial cortical node" EXACT [GOC:TermGenie] synonym: "protein localization in medial cortical node" EXACT [GOC:TermGenie] is_a: GO:0071574 ! protein localization to medial cortex created_by: mah creation_date: 2013-12-17T14:09:28Z [Term] id: GO:1902579 name: multi-organism localization namespace: biological_process def: "A localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism localization" EXACT [GOC:TermGenie] is_a: GO:0051179 ! localization is_a: GO:0051704 ! multi-organism process created_by: jl creation_date: 2013-12-18T13:51:13Z [Term] id: GO:1902581 name: multi-organism cellular localization namespace: biological_process def: "A cellular localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism cellular localization" EXACT [GOC:TermGenie] is_a: GO:0051641 ! cellular localization is_a: GO:1902579 ! multi-organism localization created_by: jl creation_date: 2013-12-18T14:04:41Z [Term] id: GO:1902583 name: obsolete multi-organism intracellular transport namespace: biological_process def: "OBSOLETE. An intracellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "multi organism intracellular transport" EXACT [GOC:TermGenie] is_obsolete: true created_by: jl creation_date: 2013-12-18T14:04:58Z [Term] id: GO:1902584 name: positive regulation of response to water deprivation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318] synonym: "activation of drought tolerance" RELATED [GOC:TermGenie] synonym: "activation of response to dehydration" NARROW [GOC:TermGenie] synonym: "activation of response to drought" NARROW [GOC:TermGenie] synonym: "activation of response to thirst" NARROW [GOC:TermGenie] synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie] synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie] synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie] synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie] synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie] synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie] synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie] synonym: "upregulation of response to drought" EXACT [GOC:TermGenie] synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie] synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000070 ! regulation of response to water deprivation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009414 ! response to water deprivation relationship: positively_regulates GO:0009414 ! response to water deprivation created_by: tb creation_date: 2013-12-19T00:31:58Z [Term] id: GO:1902586 name: multi-organism intercellular transport namespace: biological_process def: "An intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism intercellular transport" EXACT [GOC:TermGenie] is_a: GO:0044766 ! multi-organism transport created_by: jl creation_date: 2013-12-19T13:25:05Z [Term] id: GO:1902588 name: obsolete multi-organism plasmodesmata-mediated intercellular transport namespace: biological_process def: "OBSOLETE. A plasmodesmata-mediated intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "multi organism plasmodesmata-mediated intercellular transport" EXACT [GOC:TermGenie] is_obsolete: true created_by: jl creation_date: 2013-12-19T13:37:53Z [Term] id: GO:1902590 name: multi-organism organelle organization namespace: biological_process def: "An organelle organization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism organelle organization" EXACT [GOC:TermGenie] is_a: GO:0006996 ! organelle organization is_a: GO:0044764 ! multi-organism cellular process created_by: jl creation_date: 2013-12-19T15:26:08Z [Term] id: GO:1902592 name: obsolete multi-organism membrane budding namespace: biological_process def: "OBSOLETE. A membrane budding which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] comment: Obsoleted because it was a grouping term for a viral process that was incorrectly under 'multi-organism cellular process'. The children terms have been moved under 'viral process', so that this grouping term is not necessary anymore. synonym: "multi organism membrane budding" EXACT [GOC:TermGenie] is_obsolete: true created_by: jl creation_date: 2013-12-19T15:26:25Z [Term] id: GO:1902594 name: multi-organism nuclear import namespace: biological_process def: "A nuclear import which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "multi organism nuclear import" EXACT [GOC:TermGenie] is_a: GO:0044766 ! multi-organism transport is_a: GO:0051170 ! import into nucleus is_a: GO:1902581 ! multi-organism cellular localization created_by: jl creation_date: 2013-12-19T15:26:43Z [Term] id: GO:1902595 name: regulation of DNA replication origin binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] synonym: "regulation of ARS binding" NARROW [GOC:TermGenie] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003688 ! DNA replication origin binding relationship: regulates GO:0003688 ! DNA replication origin binding created_by: mah creation_date: 2013-12-19T16:19:39Z [Term] id: GO:1902596 name: negative regulation of DNA replication origin binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] synonym: "down regulation of ARS binding" NARROW [GOC:TermGenie] synonym: "down regulation of DNA replication origin binding" EXACT [GOC:TermGenie] synonym: "down-regulation of ARS binding" NARROW [GOC:TermGenie] synonym: "down-regulation of DNA replication origin binding" EXACT [GOC:TermGenie] synonym: "downregulation of ARS binding" NARROW [GOC:TermGenie] synonym: "downregulation of DNA replication origin binding" EXACT [GOC:TermGenie] synonym: "inhibition of ARS binding" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication origin binding" NARROW [GOC:TermGenie] synonym: "negative regulation of ARS binding" NARROW [GOC:TermGenie] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:1902595 ! regulation of DNA replication origin binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003688 ! DNA replication origin binding relationship: negatively_regulates GO:0003688 ! DNA replication origin binding created_by: mah creation_date: 2013-12-19T16:19:48Z [Term] id: GO:1902597 name: positive regulation of DNA replication origin binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] synonym: "activation of ARS binding" NARROW [GOC:TermGenie] synonym: "activation of DNA replication origin binding" NARROW [GOC:TermGenie] synonym: "positive regulation of ARS binding" NARROW [GOC:TermGenie] synonym: "up regulation of ARS binding" NARROW [GOC:TermGenie] synonym: "up regulation of DNA replication origin binding" EXACT [GOC:TermGenie] synonym: "up-regulation of ARS binding" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA replication origin binding" EXACT [GOC:TermGenie] synonym: "upregulation of ARS binding" NARROW [GOC:TermGenie] synonym: "upregulation of DNA replication origin binding" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:1902595 ! regulation of DNA replication origin binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003688 ! DNA replication origin binding relationship: positively_regulates GO:0003688 ! DNA replication origin binding created_by: mah creation_date: 2013-12-19T16:19:57Z [Term] id: GO:1902599 name: sulfathiazole transmembrane transport namespace: biological_process alt_id: GO:0015906 def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "sulfathiazole transport" BROAD [] synonym: "sulphathiazole transport" BROAD [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0072348 ! sulfur compound transport created_by: pr creation_date: 2013-12-20T11:08:28Z [Term] id: GO:1902600 name: proton transmembrane transport namespace: biological_process alt_id: GO:0006818 alt_id: GO:0015991 alt_id: GO:0015992 def: "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] subset: goslim_pir synonym: "ATP hydrolysis coupled proton transport" NARROW [] synonym: "hydrogen ion transmembrane transport" EXACT [] synonym: "hydrogen ion transport" RELATED [] synonym: "hydrogen transmembrane transport" EXACT [] synonym: "hydrogen transport" BROAD [] synonym: "passive proton transport, down the electrochemical gradient" NARROW [] synonym: "proton transmembrane transport" EXACT [] synonym: "proton transport" BROAD [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: pr creation_date: 2013-12-20T11:08:37Z [Term] id: GO:1902601 name: silver ion transmembrane transport namespace: biological_process def: "The directed movement of silver ion across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "silver transmembrane transport" BROAD [] is_a: GO:0098660 ! inorganic ion transmembrane transport created_by: pr creation_date: 2013-12-20T11:08:46Z [Term] id: GO:1902602 name: aluminum ion transmembrane transport namespace: biological_process def: "The process in which an aluminium ion is transported across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "aluminium ion transmembrane transport" EXACT [] synonym: "aluminium transmembrane transport" BROAD [] synonym: "aluminum transmembrane transport" BROAD [] is_a: GO:0098660 ! inorganic ion transmembrane transport created_by: pr creation_date: 2013-12-20T11:09:01Z [Term] id: GO:1902603 name: carnitine transmembrane transport namespace: biological_process def: "The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] is_a: GO:0015879 ! carnitine transport is_a: GO:0072488 ! ammonium transmembrane transport created_by: pr creation_date: 2013-12-20T11:09:11Z [Term] id: GO:1902604 name: p-aminobenzoyl-glutamate transmembrane transport namespace: biological_process def: "The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "N-(4-aminobenzoyl)-L-glutamate transmembrane transport" EXACT [] is_a: GO:0015814 ! p-aminobenzoyl-glutamate transport is_a: GO:0035442 ! dipeptide transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: pr creation_date: 2013-12-20T11:09:20Z [Term] id: GO:1902605 name: heterotrimeric G-protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:23637185] synonym: "heterotrimeric G-protein complex formation" EXACT [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase activity assembly" RELATED [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase activity formation" RELATED [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, alpha-subunit assembly" NARROW [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, alpha-subunit formation" NARROW [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, beta-subunit assembly" NARROW [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, beta-subunit formation" NARROW [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, gamma-subunit assembly" NARROW [GOC:TermGenie] synonym: "heterotrimeric G-protein GTPase, gamma-subunit formation" NARROW [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: dph creation_date: 2013-12-30T16:31:28Z [Term] id: GO:1902606 name: regulation of large conductance calcium-activated potassium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] synonym: "regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "regulation of large conductance KCa channels" EXACT [GOC:TermGenie] is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060072 ! large conductance calcium-activated potassium channel activity relationship: regulates GO:0060072 ! large conductance calcium-activated potassium channel activity created_by: sl creation_date: 2014-01-02T18:51:03Z [Term] id: GO:1902607 name: negative regulation of large conductance calcium-activated potassium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] synonym: "down regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "down regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "down regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "down-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "down-regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "down-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "downregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "downregulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "downregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "inhibition of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of BK channel activity" RELATED [GOC:TermGenie] synonym: "inhibition of BK KCa channels" NARROW [GOC:TermGenie] synonym: "inhibition of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of large conductance KCa channels" NARROW [GOC:TermGenie] synonym: "negative regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "negative regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "negative regulation of large conductance KCa channels" EXACT [GOC:TermGenie] is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity relationship: negatively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity created_by: sl creation_date: 2014-01-02T18:51:12Z [Term] id: GO:1902608 name: positive regulation of large conductance calcium-activated potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] synonym: "activation of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of BK channel activity" RELATED [GOC:TermGenie] synonym: "activation of BK KCa channels" NARROW [GOC:TermGenie] synonym: "activation of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of large conductance KCa channels" NARROW [GOC:TermGenie] synonym: "positive regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "positive regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "positive regulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "up regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "up regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "up regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "up-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "up-regulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "up-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of large conductance KCa channels" EXACT [GOC:TermGenie] synonym: "upregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of BK channel activity" RELATED [GOC:TermGenie] synonym: "upregulation of BK KCa channels" EXACT [GOC:TermGenie] synonym: "upregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of large conductance KCa channels" EXACT [GOC:TermGenie] is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity relationship: positively_regulates GO:0060072 ! large conductance calcium-activated potassium channel activity created_by: sl creation_date: 2014-01-02T18:51:21Z [Term] id: GO:1902609 name: (R)-2-hydroxy-alpha-linolenic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid." [GO_REF:0000068, GOC:TermGenie, PMID:24214535] synonym: "(R)-2-hydroxy-alpha-linolenic acid anabolism" EXACT [GOC:TermGenie] synonym: "(R)-2-hydroxy-alpha-linolenic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "(R)-2-hydroxy-alpha-linolenic acid formation" EXACT [GOC:TermGenie] synonym: "(R)-2-hydroxy-alpha-linolenic acid synthesis" EXACT [GOC:TermGenie] synonym: "2-hydroxy-octadecatrienoic acid biosynthesis" BROAD [] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: tb creation_date: 2014-01-08T01:14:03Z [Term] id: GO:1902610 name: response to N-phenylthiourea namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265] is_a: GO:0010033 ! response to organic substance created_by: rjd creation_date: 2014-01-08T01:57:49Z [Term] id: GO:1902611 name: cellular response to N-phenylthiourea namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1902610 ! response to N-phenylthiourea created_by: rjd creation_date: 2014-01-08T01:57:58Z [Term] id: GO:1902612 name: regulation of anti-Mullerian hormone signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990262 ! anti-Mullerian hormone signaling pathway relationship: regulates GO:1990262 ! anti-Mullerian hormone signaling pathway created_by: hjd creation_date: 2014-01-09T15:39:30Z [Term] id: GO:1902613 name: negative regulation of anti-Mullerian hormone signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] synonym: "down regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway relationship: negatively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway created_by: hjd creation_date: 2014-01-09T15:39:39Z [Term] id: GO:1902614 name: positive regulation of anti-Mullerian hormone signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] synonym: "activation of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway relationship: positively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway created_by: hjd creation_date: 2014-01-09T15:39:48Z [Term] id: GO:1902615 name: immune response involved in response to exogenous dsRNA namespace: biological_process def: "Any immune response that is involved in response to exogenous dsRNA." [GO_REF:0000060, GOC:pg, GOC:TermGenie, PMID:21266579] synonym: "immune response involved in response to exogenous double-stranded RNA" EXACT [GOC:TermGenie] synonym: "immune response involved in response to viral dsRNA" NARROW [GOC:TermGenie] is_a: GO:0006955 ! immune response intersection_of: GO:0006955 ! immune response intersection_of: part_of GO:0043330 ! response to exogenous dsRNA relationship: part_of GO:0043330 ! response to exogenous dsRNA created_by: tb creation_date: 2014-01-10T01:29:25Z [Term] id: GO:1902616 name: acyl carnitine transmembrane transport namespace: biological_process def: "The process in which acyl carnitine is transported across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "O-acylcarnitine transmembrane transport" EXACT [] is_a: GO:0006844 ! acyl carnitine transport is_a: GO:0072488 ! ammonium transmembrane transport created_by: pr creation_date: 2014-01-10T11:07:30Z [Term] id: GO:1902617 name: response to fluoride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance created_by: kmv creation_date: 2014-01-10T19:41:49Z [Term] id: GO:1902618 name: cellular response to fluoride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1902617 ! response to fluoride created_by: kmv creation_date: 2014-01-10T19:41:58Z [Term] id: GO:1902619 name: regulation of microtubule minus-end binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623] is_a: GO:1904526 ! regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051011 ! microtubule minus-end binding relationship: regulates GO:0051011 ! microtubule minus-end binding created_by: tb creation_date: 2014-01-14T22:17:16Z [Term] id: GO:1902620 name: positive regulation of microtubule minus-end binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623] synonym: "activation of microtubule minus-end binding" NARROW [GOC:TermGenie] synonym: "up regulation of microtubule minus-end binding" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule minus-end binding" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule minus-end binding" EXACT [GOC:TermGenie] is_a: GO:1902619 ! regulation of microtubule minus-end binding is_a: GO:1904528 ! positive regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051011 ! microtubule minus-end binding relationship: positively_regulates GO:0051011 ! microtubule minus-end binding created_by: tb creation_date: 2014-01-14T22:17:25Z [Term] id: GO:1902621 name: actomyosin contractile ring disassembly namespace: biological_process def: "The disaggregation of an actomyosin contractile ring into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:14602073, PMID:22891673] synonym: "actomyosin ring disassembly" RELATED [GOC:TermGenie] synonym: "CAR disassembly" EXACT [GOC:TermGenie] synonym: "constriction ring disassembly" RELATED [GOC:TermGenie] synonym: "contractile actomyosin ring disassembly" EXACT [GOC:TermGenie] synonym: "cytokinetic ring disassembly" RELATED [GOC:TermGenie] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0032506 ! cytokinetic process is_a: GO:0044837 ! actomyosin contractile ring organization created_by: mah creation_date: 2014-01-15T09:27:26Z [Term] id: GO:1902622 name: regulation of neutrophil migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990266 ! neutrophil migration relationship: regulates GO:1990266 ! neutrophil migration created_by: sl creation_date: 2014-01-15T18:58:39Z [Term] id: GO:1902623 name: negative regulation of neutrophil migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] synonym: "down regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "down-regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "downregulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "inhibition of neutrophil migration" NARROW [GOC:TermGenie] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990266 ! neutrophil migration relationship: negatively_regulates GO:1990266 ! neutrophil migration created_by: sl creation_date: 2014-01-15T18:58:49Z [Term] id: GO:1902624 name: positive regulation of neutrophil migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] synonym: "activation of neutrophil migration" NARROW [GOC:TermGenie] synonym: "up regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "up-regulation of neutrophil migration" EXACT [GOC:TermGenie] synonym: "upregulation of neutrophil migration" EXACT [GOC:TermGenie] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990266 ! neutrophil migration relationship: positively_regulates GO:1990266 ! neutrophil migration created_by: sl creation_date: 2014-01-15T18:58:58Z [Term] id: GO:1902625 name: negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:9671458] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010515 ! negative regulation of induction of conjugation with cellular fusion is_a: GO:1900406 ! regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion created_by: mah creation_date: 2014-01-16T13:52:24Z [Term] id: GO:1902626 name: assembly of large subunit precursor of preribosome namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702] synonym: "66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "66S preribosome formation" NARROW [GOC:TermGenie] synonym: "preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] is_a: GO:0022618 ! ribonucleoprotein complex assembly created_by: tb creation_date: 2014-01-16T19:38:05Z [Term] id: GO:1902627 name: regulation of assembly of large subunit precursor of preribosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702] synonym: "regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "regulation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902626 ! assembly of large subunit precursor of preribosome relationship: regulates GO:1902626 ! assembly of large subunit precursor of preribosome created_by: tb creation_date: 2014-01-16T22:11:45Z [Term] id: GO:1902628 name: positive regulation of assembly of large subunit precursor of preribosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702] synonym: "activation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "activation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "activation of assembly of large subunit precursor of preribosome" NARROW [GOC:TermGenie] synonym: "activation of preribosome, large subunit precursor formation" NARROW [GOC:TermGenie] synonym: "positive regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "positive regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] synonym: "up regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "up regulation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "up regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] synonym: "up regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] synonym: "up-regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "up-regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] synonym: "up-regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] synonym: "upregulation of 66S preribosome assembly" NARROW [GOC:TermGenie] synonym: "upregulation of 66S preribosome formation" NARROW [GOC:TermGenie] synonym: "upregulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] synonym: "upregulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1902627 ! regulation of assembly of large subunit precursor of preribosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome relationship: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome created_by: tb creation_date: 2014-01-16T22:11:55Z [Term] id: GO:1902629 name: regulation of mRNA stability involved in cellular response to UV namespace: biological_process def: "Any regulation of mRNA stability that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:10954610] synonym: "regulation of mRNA stability involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie] synonym: "regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie] synonym: "regulation of mRNA stability involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie] synonym: "regulation of mRNA stability involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie] is_a: GO:0043488 ! regulation of mRNA stability intersection_of: GO:0043488 ! regulation of mRNA stability intersection_of: part_of GO:0034644 ! cellular response to UV relationship: part_of GO:0034644 ! cellular response to UV created_by: mah creation_date: 2014-01-17T12:23:38Z [Term] id: GO:1902630 name: regulation of membrane hyperpolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060081 ! membrane hyperpolarization relationship: regulates GO:0060081 ! membrane hyperpolarization created_by: krc creation_date: 2014-01-17T18:27:56Z [Term] id: GO:1902631 name: negative regulation of membrane hyperpolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] synonym: "down regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] synonym: "downregulation of membrane hyperpolarization" EXACT [GOC:TermGenie] synonym: "inhibition of membrane hyperpolarization" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1902630 ! regulation of membrane hyperpolarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060081 ! membrane hyperpolarization relationship: negatively_regulates GO:0060081 ! membrane hyperpolarization created_by: krc creation_date: 2014-01-17T18:28:05Z [Term] id: GO:1902632 name: positive regulation of membrane hyperpolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] synonym: "activation of membrane hyperpolarization" NARROW [GOC:TermGenie] synonym: "up regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] synonym: "upregulation of membrane hyperpolarization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1902630 ! regulation of membrane hyperpolarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060081 ! membrane hyperpolarization relationship: positively_regulates GO:0060081 ! membrane hyperpolarization created_by: krc creation_date: 2014-01-17T18:28:14Z [Term] id: GO:1902633 name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0046488 ! phosphatidylinositol metabolic process created_by: di creation_date: 2014-01-18T00:34:27Z [Term] id: GO:1902634 name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0031161 ! phosphatidylinositol catabolic process is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process created_by: di creation_date: 2014-01-18T00:34:36Z [Term] id: GO:1902635 name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006661 ! phosphatidylinositol biosynthetic process is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process created_by: di creation_date: 2014-01-18T00:34:45Z [Term] id: GO:1902636 name: kinociliary basal body namespace: cellular_component def: "A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574] synonym: "cilial basal body of kinocilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of kinocilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of kinocilium" EXACT [GOC:TermGenie] synonym: "kinocilial basal body" EXACT [] synonym: "kinocilium basal body" EXACT [] synonym: "kinocilium ciliary basal body" EXACT [] synonym: "microtubule basal body of kinocilium" EXACT [GOC:TermGenie] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0060091 ! kinocilium relationship: part_of GO:0060091 ! kinocilium created_by: pr creation_date: 2014-01-20T13:48:45Z [Term] id: GO:1902637 name: neural crest cell differentiation involved in thymus development namespace: biological_process def: "Any neural crest cell differentiation that is involved in thymus development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542] is_a: GO:0014033 ! neural crest cell differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: part_of GO:0048538 ! thymus development relationship: part_of GO:0048538 ! thymus development created_by: pr creation_date: 2014-01-21T10:03:20Z [Term] id: GO:1902638 name: neural crest cell differentiation involved in parathyroid gland development namespace: biological_process def: "Any neural crest cell differentiation that is involved in parathyroid gland development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317] is_a: GO:0014033 ! neural crest cell differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: part_of GO:0060017 ! parathyroid gland development relationship: part_of GO:0060017 ! parathyroid gland development created_by: pr creation_date: 2014-01-21T10:03:29Z [Term] id: GO:1902639 name: propan-2-ol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237] synonym: "Isopropanol metabolic process" EXACT [] synonym: "Isopropyl alcohol metabolic process" EXACT [] synonym: "propan-2-ol metabolism" EXACT [GOC:TermGenie] is_a: GO:1902652 ! secondary alcohol metabolic process created_by: tt creation_date: 2014-01-21T13:57:13Z [Term] id: GO:1902640 name: propan-2-ol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237] synonym: "Isopropanol biosynthetic process" EXACT [] synonym: "Isopropyl alcohol biosynthetic process" EXACT [] synonym: "propan-2-ol anabolism" EXACT [GOC:TermGenie] synonym: "propan-2-ol biosynthesis" EXACT [GOC:TermGenie] synonym: "propan-2-ol formation" EXACT [GOC:TermGenie] synonym: "propan-2-ol synthesis" EXACT [GOC:TermGenie] is_a: GO:1902639 ! propan-2-ol metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: tt creation_date: 2014-01-21T13:57:22Z [Term] id: GO:1902641 name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0060696 ! regulation of phospholipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process relationship: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process created_by: di creation_date: 2014-01-21T17:54:14Z [Term] id: GO:1902642 name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process is_a: GO:1903726 ! negative regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process relationship: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process created_by: di creation_date: 2014-01-21T17:54:23Z [Term] id: GO:1902643 name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0060697 ! positive regulation of phospholipid catabolic process is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process relationship: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process created_by: di creation_date: 2014-01-21T17:54:32Z [Term] id: GO:1902644 name: tertiary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "tertiary alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process created_by: tt creation_date: 2014-01-21T17:53:53Z [Term] id: GO:1902645 name: tertiary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "tertiary alcohol anabolism" EXACT [GOC:TermGenie] synonym: "tertiary alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "tertiary alcohol formation" EXACT [GOC:TermGenie] synonym: "tertiary alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1902644 ! tertiary alcohol metabolic process created_by: tt creation_date: 2014-01-21T17:54:02Z [Term] id: GO:1902646 name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process relationship: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process created_by: di creation_date: 2014-01-21T17:57:57Z [Term] id: GO:1902647 name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie] synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process relationship: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process created_by: di creation_date: 2014-01-21T17:58:06Z [Term] id: GO:1902648 name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie] synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0010513 ! positive regulation of phosphatidylinositol biosynthetic process is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process relationship: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process created_by: di creation_date: 2014-01-21T17:58:15Z [Term] id: GO:1902649 name: regulation of histone H2A-H2B dimer displacement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001208 ! histone H2A-H2B dimer displacement relationship: regulates GO:0001208 ! histone H2A-H2B dimer displacement created_by: di creation_date: 2014-01-21T18:19:04Z [Term] id: GO:1902650 name: negative regulation of histone H2A-H2B dimer displacement namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] synonym: "down regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] synonym: "downregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] synonym: "inhibition of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie] is_a: GO:1902649 ! regulation of histone H2A-H2B dimer displacement is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001208 ! histone H2A-H2B dimer displacement relationship: negatively_regulates GO:0001208 ! histone H2A-H2B dimer displacement created_by: di creation_date: 2014-01-21T18:19:14Z [Term] id: GO:1902651 name: positive regulation of histone H2A-H2B dimer displacement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] synonym: "activation of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie] synonym: "up regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] synonym: "upregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] is_a: GO:1902649 ! regulation of histone H2A-H2B dimer displacement is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001208 ! histone H2A-H2B dimer displacement relationship: positively_regulates GO:0001208 ! histone H2A-H2B dimer displacement created_by: di creation_date: 2014-01-21T18:19:23Z [Term] id: GO:1902652 name: secondary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:14:52Z [Term] id: GO:1902653 name: secondary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie] synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "secondary alcohol formation" EXACT [GOC:TermGenie] synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:15:02Z [Term] id: GO:1902654 name: aromatic primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878] synonym: "aromatic primary alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: tt creation_date: 2014-01-22T10:47:21Z [Term] id: GO:1902655 name: aromatic primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878] synonym: "aromatic primary alcohol anabolism" EXACT [GOC:TermGenie] synonym: "aromatic primary alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "aromatic primary alcohol formation" EXACT [GOC:TermGenie] synonym: "aromatic primary alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1902654 ! aromatic primary alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:47:30Z [Term] id: GO:1902656 name: calcium ion import into cytosol namespace: biological_process def: "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw] synonym: "calcium import into cytosol" BROAD [] is_a: GO:0060402 ! calcium ion transport into cytosol is_a: GO:0070509 ! calcium ion import created_by: pr creation_date: 2014-01-22T13:41:11Z [Term] id: GO:1902657 name: protein localization to prospore membrane namespace: biological_process alt_id: GO:0072693 alt_id: GO:1902658 def: "A process in which a protein is transported to, or maintained in, a location within a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347] synonym: "establishment of protein localisation in prospore membrane" RELATED [GOC:TermGenie] synonym: "establishment of protein localisation to prospore membrane" RELATED [GOC:TermGenie] synonym: "establishment of protein localization in prospore membrane" RELATED [GOC:TermGenie] synonym: "establishment of protein localization to prospore membrane" RELATED [] synonym: "protein localisation in prospore membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to prospore membrane" EXACT [GOC:TermGenie] synonym: "protein localization in prospore membrane" EXACT [GOC:TermGenie] synonym: "protein targeting to ascospore-type prospore membrane" RELATED [GOC:mah] synonym: "protein targeting to forespore membrane" RELATED [GOC:mah] synonym: "protein targeting to FSM" RELATED [GOC:mah] synonym: "protein targeting to prospore membrane" RELATED [] synonym: "protein-prospore membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane created_by: dph creation_date: 2011-11-16T11:28:26Z [Term] id: GO:1902659 name: regulation of glucose mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] synonym: "regulation of glucose mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010255 ! glucose mediated signaling pathway relationship: regulates GO:0010255 ! glucose mediated signaling pathway created_by: di creation_date: 2014-01-28T17:54:21Z [Term] id: GO:1902660 name: negative regulation of glucose mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] synonym: "down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902659 ! regulation of glucose mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010255 ! glucose mediated signaling pathway relationship: negatively_regulates GO:0010255 ! glucose mediated signaling pathway created_by: di creation_date: 2014-01-28T17:54:31Z [Term] id: GO:1902661 name: positive regulation of glucose mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] synonym: "activation of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "positive regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "up regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "upregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glucose mediated signalling" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902659 ! regulation of glucose mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010255 ! glucose mediated signaling pathway relationship: positively_regulates GO:0010255 ! glucose mediated signaling pathway created_by: di creation_date: 2014-01-28T17:54:47Z [Term] id: GO:1902662 name: regulation of peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] synonym: "regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] is_a: GO:1903059 ! regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation relationship: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation created_by: mm2 creation_date: 2014-01-29T11:33:09Z [Term] id: GO:1902663 name: negative regulation of peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] synonym: "down regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "down regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "inhibition of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie] synonym: "inhibition of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie] synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "negative regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation is_a: GO:1903060 ! negative regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation relationship: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation created_by: mm2 creation_date: 2014-01-29T11:33:19Z [Term] id: GO:1902664 name: positive regulation of peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] synonym: "activation of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie] synonym: "activation of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie] synonym: "activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie] synonym: "positive regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation is_a: GO:1903061 ! positive regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation relationship: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation created_by: mm2 creation_date: 2014-01-29T11:33:28Z [Term] id: GO:1902665 name: response to isobutanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:24014527] synonym: "response to 2-methylpropan-1-ol" EXACT [GOC:mengo_curators] is_a: GO:0097305 ! response to alcohol created_by: tt creation_date: 2014-01-29T14:06:58Z [Term] id: GO:1902666 name: protein localization to Mmi1 nuclear focus complex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex." [GO_REF:0000087, GOC:TermGenie, PMID:23980030] synonym: "protein localisation in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] synonym: "protein localisation to Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] synonym: "protein localization in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] is_a: GO:1903405 ! protein localization to nuclear body created_by: mah creation_date: 2014-01-30T10:42:17Z [Term] id: GO:1902667 name: regulation of axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007411 ! axon guidance relationship: regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:10Z [Term] id: GO:1902668 name: negative regulation of axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "down regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "down regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "down regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "down-regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "down-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "down-regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "downregulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "downregulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "downregulation of axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "inhibition of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "inhibition of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "inhibition of axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie] synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0050771 ! negative regulation of axonogenesis is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007411 ! axon guidance relationship: negatively_regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:19Z [Term] id: GO:1902669 name: positive regulation of axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] synonym: "activation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "activation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "activation of axon guidance" NARROW [GOC:TermGenie] synonym: "activation of axon pathfinding" NARROW [GOC:TermGenie] synonym: "positive regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "positive regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "positive regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "up regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "up regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "up-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "up-regulation of axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:0050772 ! positive regulation of axonogenesis is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007411 ! axon guidance relationship: positively_regulates GO:0007411 ! axon guidance created_by: hjd creation_date: 2014-01-31T18:50:29Z [Term] id: GO:1902670 name: carbon dioxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402] synonym: "CO2 binding" EXACT [] is_a: GO:0008144 ! drug binding created_by: bhm creation_date: 2014-02-04T10:38:41Z [Term] id: GO:1902671 name: left anterior basal body namespace: cellular_component def: "Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of left anterior cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of left anterior flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left anterior cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left anterior flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of left anterior cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of left anterior flagellum" EXACT [GOC:TermGenie] synonym: "left anterior flagellum ciliary basal body" EXACT [] synonym: "microtubule basal body of left anterior cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left anterior flagellum" EXACT [GOC:TermGenie] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097554 ! left anterior flagellum relationship: part_of GO:0097554 ! left anterior flagellum created_by: pr creation_date: 2014-02-05T14:28:44Z [Term] id: GO:1902672 name: right anterior basal body namespace: cellular_component def: "Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of right anterior cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of right anterior flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right anterior cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right anterior flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of right anterior cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of right anterior flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right anterior cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right anterior flagellum" EXACT [GOC:TermGenie] synonym: "right anterior flagellum ciliary basal body" EXACT [] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097555 ! right anterior flagellum relationship: part_of GO:0097555 ! right anterior flagellum created_by: pr creation_date: 2014-02-05T14:46:26Z [Term] id: GO:1902673 name: left posteriolateral basal body namespace: cellular_component def: "Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilial basal body of left posterolateral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left posterolateral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of left posterolateral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "left posteriolateral flagellum ciliary basal body" EXACT [] synonym: "microtubule basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left posterolateral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097556 ! left posteriolateral flagellum relationship: part_of GO:0097556 ! left posteriolateral flagellum created_by: pr creation_date: 2014-02-05T14:49:25Z [Term] id: GO:1902674 name: right posteriolateral basal body namespace: cellular_component def: "Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilial basal body of right posterolateral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right posterolateral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of right posterolateral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right posterolateral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] synonym: "right posteriolateral flagellum ciliary basal body" EXACT [] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097557 ! right posteriolateral flagellum relationship: part_of GO:0097557 ! right posteriolateral flagellum created_by: pr creation_date: 2014-02-05T14:52:04Z [Term] id: GO:1902675 name: left ventral basal body namespace: cellular_component def: "Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of left ventral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of left ventral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left ventral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left ventral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of left ventral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of left ventral flagellum" EXACT [GOC:TermGenie] synonym: "left ventral flagellum ciliary basal body" EXACT [] synonym: "microtubule basal body of left ventral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left ventral flagellum" EXACT [GOC:TermGenie] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097558 ! left ventral flagellum relationship: part_of GO:0097558 ! left ventral flagellum created_by: pr creation_date: 2014-02-05T14:54:54Z [Term] id: GO:1902676 name: right ventral basal body namespace: cellular_component def: "Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of right ventral cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of right ventral flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right ventral cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right ventral flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of right ventral cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of right ventral flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right ventral cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right ventral flagellum" EXACT [GOC:TermGenie] synonym: "right ventral flagellum ciliary basal body" EXACT [] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097559 ! right ventral flagellum relationship: part_of GO:0097559 ! right ventral flagellum created_by: pr creation_date: 2014-02-05T14:58:13Z [Term] id: GO:1902677 name: left caudal basal body namespace: cellular_component def: "Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of left caudal cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of left caudal flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left caudal cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of left caudal flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of left caudal cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of left caudal flagellum" EXACT [GOC:TermGenie] synonym: "left caudal flagellum ciliary basal body" EXACT [] synonym: "microtubule basal body of left caudal cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of left caudal flagellum" EXACT [GOC:TermGenie] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097560 ! left caudal flagellum relationship: part_of GO:0097560 ! left caudal flagellum created_by: pr creation_date: 2014-02-05T15:00:36Z [Term] id: GO:1902678 name: right caudal basal body namespace: cellular_component def: "Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. synonym: "cilial basal body of right caudal cilium" EXACT [GOC:TermGenie] synonym: "cilial basal body of right caudal flagellum" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right caudal cilium" EXACT [GOC:TermGenie] synonym: "ciliary basal body of right caudal flagellum" EXACT [GOC:TermGenie] synonym: "cilium basal body of right caudal cilium" EXACT [GOC:TermGenie] synonym: "cilium basal body of right caudal flagellum" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right caudal cilium" EXACT [GOC:TermGenie] synonym: "microtubule basal body of right caudal flagellum" EXACT [GOC:TermGenie] synonym: "right caudal flagellum ciliary basal body" EXACT [] is_a: GO:0036064 ! ciliary basal body intersection_of: GO:0036064 ! ciliary basal body intersection_of: part_of GO:0097561 ! right caudal flagellum relationship: part_of GO:0097561 ! right caudal flagellum created_by: pr creation_date: 2014-02-05T15:02:56Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process relationship: positively_regulates GO:0032774 ! RNA biosynthetic process created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902681 name: regulation of replication fork arrest at rDNA repeats namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats." [GO_REF:0000058, GOC:TermGenie, PMID:23260662] synonym: "regulation of replication fork arrest at ribosomal DNA repeats" EXACT [GOC:TermGenie] synonym: "regulation of replication fork blocking at rDNA repeats" EXACT [GOC:TermGenie] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031582 ! replication fork arrest at rDNA repeats relationship: regulates GO:0031582 ! replication fork arrest at rDNA repeats created_by: mah creation_date: 2014-02-05T16:59:21Z [Term] id: GO:1902682 name: protein localization to nuclear pericentric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nuclear pericentric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20211136] synonym: "protein localisation in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0071459 ! protein localization to chromosome, centromeric region is_a: GO:0097355 ! protein localization to heterochromatin created_by: mah creation_date: 2014-02-05T16:59:30Z [Term] id: GO:1902683 name: regulation of receptor localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097120 ! receptor localization to synapse relationship: regulates GO:0097120 ! receptor localization to synapse created_by: kmv creation_date: 2014-02-07T17:38:31Z [Term] id: GO:1902684 name: negative regulation of receptor localization to synapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097120 ! receptor localization to synapse relationship: negatively_regulates GO:0097120 ! receptor localization to synapse created_by: kmv creation_date: 2014-02-07T17:38:41Z [Term] id: GO:1902685 name: positive regulation of receptor localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie] is_a: GO:1902474 ! positive regulation of protein localization to synapse is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097120 ! receptor localization to synapse relationship: positively_regulates GO:0097120 ! receptor localization to synapse created_by: kmv creation_date: 2014-02-07T17:38:51Z [Term] id: GO:1902686 name: mitochondrial outer membrane permeabilization involved in programmed cell death namespace: biological_process def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314] synonym: "mitochondrial membrane permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in PCD" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeability transition involved in regulated cell death" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in PCD" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial membrane permeabilization involved in regulated cell death" RELATED [GOC:TermGenie] synonym: "mitochondrial outer membrane permeabilization during programmed cell death" EXACT [] synonym: "mitochondrial permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in PCD" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in programmed cell death" NARROW [GOC:TermGenie] synonym: "mitochondrial permeability transition involved in regulated cell death" RELATED [GOC:TermGenie] synonym: "MPT involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "MPT involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "MPT involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "MPT involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "MPT involved in PCD" NARROW [GOC:TermGenie] synonym: "MPT involved in programmed cell death" NARROW [GOC:TermGenie] synonym: "MPT involved in regulated cell death" RELATED [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in PCD" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death" EXACT [] synonym: "positive regulation of mitochondrial membrane permeability involved in regulated cell death" RELATED [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in PCD" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death" EXACT [GOC:TermGenie] synonym: "positive regulation of transport across mitochondrial membrane involved in regulated cell death" RELATED [GOC:TermGenie] is_a: GO:0035794 ! positive regulation of mitochondrial membrane permeability intersection_of: GO:0035794 ! positive regulation of mitochondrial membrane permeability intersection_of: part_of GO:0012501 ! programmed cell death relationship: part_of GO:0012501 ! programmed cell death created_by: pr creation_date: 2014-02-10T12:56:34Z [Term] id: GO:1902687 name: glucosidase complex namespace: cellular_component def: "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] comment: An example of this is ygjK in E. coli (P42592) in PMID:23826932. is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2014-02-12T10:55:10Z [Term] id: GO:1902688 name: regulation of NAD metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] synonym: "regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019674 ! NAD metabolic process relationship: regulates GO:0019674 ! NAD metabolic process created_by: di creation_date: 2014-02-12T18:58:50Z [Term] id: GO:1902689 name: negative regulation of NAD metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] synonym: "down regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "down regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "down-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "downregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of NAD (oxidized) metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of NAD metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of NAD metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of oxidized NAD metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of oxidized NAD metabolism" NARROW [GOC:TermGenie] synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "negative regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1902688 ! regulation of NAD metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019674 ! NAD metabolic process relationship: negatively_regulates GO:0019674 ! NAD metabolic process created_by: di creation_date: 2014-02-12T18:58:59Z [Term] id: GO:1902690 name: positive regulation of NAD metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] synonym: "activation of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie] synonym: "activation of NAD (oxidized) metabolism" NARROW [GOC:TermGenie] synonym: "activation of NAD metabolic process" NARROW [GOC:TermGenie] synonym: "activation of NAD metabolism" NARROW [GOC:TermGenie] synonym: "activation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "activation of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] synonym: "activation of oxidized NAD metabolic process" NARROW [GOC:TermGenie] synonym: "activation of oxidized NAD metabolism" NARROW [GOC:TermGenie] synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "up regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "up-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of NAD metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of NAD metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] synonym: "upregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1902688 ! regulation of NAD metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019674 ! NAD metabolic process relationship: positively_regulates GO:0019674 ! NAD metabolic process created_by: di creation_date: 2014-02-12T18:59:09Z [Term] id: GO:1902691 name: respiratory basal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell." [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629] comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders synonym: "airway basal cell differentiation" EXACT [MP:0011114] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0048863 ! stem cell differentiation created_by: cjmungall creation_date: 2014-02-13T23:41:24Z [Term] id: GO:1902692 name: regulation of neuroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496] is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0072091 ! regulation of stem cell proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007405 ! neuroblast proliferation relationship: regulates GO:0007405 ! neuroblast proliferation created_by: rl creation_date: 2014-02-18T10:03:31Z [Term] id: GO:1902693 name: superoxide dismutase complex namespace: cellular_component def: "A protein complex which is capable of superoxide dismutase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10026301] comment: An example of this is SOD1 in Saccharomyces cerevisiae S288c (UniProt symbol P00445) in PMID:10026301. is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2014-02-18T11:10:11Z [Term] id: GO:1902694 name: superoxide dismutase copper chaperone complex namespace: cellular_component def: "A protein complex which is capable of superoxide dismutase copper chaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947] comment: An example of this is CCS1 in Saccharomyces cerevisiae S288c (UniProt symbol P40202) in PMID:10426947. is_a: GO:0150005 ! enzyme activator complex is_a: GO:1902695 ! metallochaperone complex created_by: bhm creation_date: 2014-02-18T11:13:45Z [Term] id: GO:1902695 name: metallochaperone complex namespace: cellular_component def: "A protein complex which is capable of metallochaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-02-18T11:34:40Z [Term] id: GO:1902696 name: glycine catabolic process to isobutanol namespace: biological_process alt_id: GO:1990293 def: "The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:23642236] synonym: "glycine breakdown to isobutanol" EXACT [GOC:TermGenie] synonym: "glycine catabolism to isobutanol" EXACT [GOC:TermGenie] synonym: "glycine degradation to isobutanol" EXACT [GOC:TermGenie] is_a: GO:0006546 ! glycine catabolic process is_a: GO:1901960 ! isobutanol metabolic process created_by: tb creation_date: 2014-02-19T18:00:12Z [Term] id: GO:1902697 name: valine catabolic process to isobutanol namespace: biological_process alt_id: GO:1990292 def: "The chemical reactions and pathways resulting in the breakdown of valine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:9748245] synonym: "valine breakdown to isobutanol" EXACT [GOC:TermGenie] synonym: "valine catabolism to isobutanol" EXACT [GOC:TermGenie] synonym: "valine degradation to isobutanol" EXACT [GOC:TermGenie] is_a: GO:0006574 ! valine catabolic process is_a: GO:1901960 ! isobutanol metabolic process created_by: tb creation_date: 2014-02-19T18:28:19Z [Term] id: GO:1902698 name: pentose catabolic process to butyrate namespace: biological_process alt_id: GO:1990288 def: "The chemical reactions and pathways resulting in the breakdown of pentose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "acidogenesis" BROAD [GOC:tt] synonym: "pentose breakdown to butyrate" EXACT [GOC:TermGenie] synonym: "pentose catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "pentose degradation to butyrate" EXACT [GOC:TermGenie] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0019605 ! butyrate metabolic process created_by: tb creation_date: 2014-02-19T18:28:28Z [Term] id: GO:1902699 name: pentose catabolic process to acetate namespace: biological_process alt_id: GO:1990289 def: "The chemical reactions and pathways resulting in the breakdown of pentose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "acidogenesis" BROAD [GOC:tt] synonym: "pentose breakdown to acetate" EXACT [GOC:TermGenie] synonym: "pentose catabolism to acetate" EXACT [GOC:TermGenie] synonym: "pentose degradation to acetate" EXACT [GOC:TermGenie] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0019323 ! pentose catabolic process created_by: tb creation_date: 2014-02-19T18:28:38Z [Term] id: GO:1902700 name: pentose catabolic process to butan-1-ol namespace: biological_process alt_id: GO:1990290 def: "The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "pentose breakdown to butan-1-ol" EXACT [GOC:TermGenie] synonym: "pentose catabolic process to 1-butanol" EXACT [GOC:tt] synonym: "pentose catabolic process to butanol" EXACT [GOC:tt] synonym: "pentose catabolism to butan-1-ol" EXACT [GOC:TermGenie] synonym: "pentose degradation to butan-1-ol" EXACT [GOC:TermGenie] synonym: "solventogenesis" BROAD [GOC:tt] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0071270 ! 1-butanol metabolic process created_by: tb creation_date: 2014-02-19T18:28:47Z [Term] id: GO:1902701 name: pentose catabolic process to propan-2-ol namespace: biological_process alt_id: GO:1990291 def: "The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "pentose breakdown to propan-2-ol" EXACT [GOC:TermGenie] synonym: "pentose catabolic process to isopropanol" EXACT [GOC:tt] synonym: "pentose catabolic process to isopropyl alcohol" EXACT [GOC:tt] synonym: "pentose catabolism to propan-2-ol" EXACT [GOC:TermGenie] synonym: "pentose degradation to propan-2-ol" EXACT [GOC:TermGenie] synonym: "solventogenesis" BROAD [GOC:tt] is_a: GO:0019323 ! pentose catabolic process is_a: GO:1902639 ! propan-2-ol metabolic process created_by: tb creation_date: 2014-02-19T18:28:57Z [Term] id: GO:1902702 name: hexose catabolic process to propan-2-ol namespace: biological_process alt_id: GO:1990283 def: "The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "hexose breakdown to propan-2-ol" EXACT [GOC:TermGenie] synonym: "hexose catabolic process to isopropanol" EXACT [GOC:tt] synonym: "hexose catabolic process to isopropyl alcohol" EXACT [GOC:tt] synonym: "hexose catabolism to propan-2-ol" EXACT [GOC:TermGenie] synonym: "hexose degradation to propan-2-ol" EXACT [GOC:TermGenie] synonym: "solventogenesis" RELATED [GOC:tt] is_a: GO:0019320 ! hexose catabolic process is_a: GO:1902639 ! propan-2-ol metabolic process created_by: tb creation_date: 2014-02-19T18:42:54Z [Term] id: GO:1902703 name: hexose catabolic process to butan-1-ol namespace: biological_process alt_id: GO:1990284 def: "The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "hexose breakdown to butan-1-ol" EXACT [GOC:TermGenie] synonym: "hexose catabolic process to 1-butanol" EXACT [GOC:tt] synonym: "hexose catabolic process to butanol" EXACT [GOC:tt] synonym: "hexose catabolism to butan-1-ol" EXACT [GOC:TermGenie] synonym: "hexose degradation to butan-1-ol" EXACT [GOC:TermGenie] synonym: "solventogenesis" BROAD [GOC:tt] is_a: GO:0019320 ! hexose catabolic process is_a: GO:0071270 ! 1-butanol metabolic process created_by: tb creation_date: 2014-02-19T18:43:04Z [Term] id: GO:1902704 name: hexose catabolic process to acetone namespace: biological_process alt_id: GO:1990285 def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetone." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "hexose breakdown to acetone" EXACT [GOC:TermGenie] synonym: "hexose catabolic process to 2-propanone" EXACT [GOC:tt] synonym: "hexose catabolism to acetone" EXACT [GOC:TermGenie] synonym: "hexose degradation to acetone" EXACT [GOC:TermGenie] synonym: "solventogenesis" BROAD [GOC:tt] is_a: GO:0019320 ! hexose catabolic process is_a: GO:0043443 ! acetone metabolic process created_by: tb creation_date: 2014-02-19T18:43:13Z [Term] id: GO:1902705 name: hexose catabolic process to butyrate namespace: biological_process alt_id: GO:1990287 def: "The chemical reactions and pathways resulting in the breakdown of hexose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "acidogenesis" BROAD [GOC:tt] synonym: "hexose breakdown to butyrate" EXACT [GOC:TermGenie] synonym: "hexose catabolism to butyrate" EXACT [GOC:TermGenie] synonym: "hexose degradation to butyrate" EXACT [GOC:TermGenie] is_a: GO:0019320 ! hexose catabolic process is_a: GO:0019605 ! butyrate metabolic process created_by: tb creation_date: 2014-02-19T18:43:32Z [Term] id: GO:1902706 name: hexose catabolic process to acetate namespace: biological_process alt_id: GO:1990286 def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "acidogenesis" BROAD [GOC:tt] synonym: "hexose breakdown to acetate" EXACT [GOC:TermGenie] synonym: "hexose catabolism to acetate" EXACT [GOC:TermGenie] synonym: "hexose degradation to acetate" EXACT [GOC:TermGenie] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0019320 ! hexose catabolic process created_by: tb creation_date: 2014-02-19T18:43:23Z [Term] id: GO:1902707 name: hexose catabolic process to ethanol namespace: biological_process alt_id: GO:1990282 def: "The chemical reactions and pathways resulting in the breakdown of hexose to ethanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] synonym: "hexose breakdown to ethanol" EXACT [GOC:TermGenie] synonym: "hexose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "hexose degradation to ethanol" EXACT [GOC:TermGenie] synonym: "solventogenesis" BROAD [GOC:tt] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0019320 ! hexose catabolic process created_by: tb creation_date: 2014-02-19T21:33:08Z [Term] id: GO:1902708 name: response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2014-02-20T13:49:54Z [Term] id: GO:1902709 name: cellular response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1902708 ! response to plumbagin created_by: mah creation_date: 2014-02-20T13:50:04Z [Term] id: GO:1902710 name: GABA receptor complex namespace: cellular_component def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] synonym: "gamma-aminobutyric acid receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex created_by: bhm creation_date: 2014-02-20T16:07:48Z [Term] id: GO:1902711 name: GABA-A receptor complex namespace: cellular_component def: "A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor)." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] comment: An example of this is GBRA1 in human (UniProt symbol P14867) in PMID:18790874. is_a: GO:1902710 ! GABA receptor complex created_by: bhm creation_date: 2014-02-21T09:19:58Z [Term] id: GO:1902712 name: G protein-coupled GABA receptor complex namespace: cellular_component def: "A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874. synonym: "G-protein coupled GABA receptor complex" EXACT [] is_a: GO:0038037 ! G protein-coupled receptor dimeric complex is_a: GO:0098878 ! neurotransmitter receptor complex is_a: GO:1902710 ! GABA receptor complex created_by: bhm creation_date: 2014-02-21T09:47:03Z [Term] id: GO:1902713 name: regulation of interferon-gamma secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] synonym: "regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "regulation of type II IFN secretion" BROAD [GOC:TermGenie] synonym: "regulation of type II interferon secretion" BROAD [GOC:TermGenie] is_a: GO:0032649 ! regulation of interferon-gamma production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072643 ! interferon-gamma secretion relationship: regulates GO:0072643 ! interferon-gamma secretion created_by: als creation_date: 2014-02-21T16:34:19Z [Term] id: GO:1902714 name: negative regulation of interferon-gamma secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] synonym: "down regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "down regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "down regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "downregulation of interferon-gamma secretion" EXACT [GOC:TermGenie] synonym: "inhibition of IFN-gamma secretion" NARROW [GOC:TermGenie] synonym: "inhibition of IFNG secretion" NARROW [GOC:TermGenie] synonym: "inhibition of interferon-gamma secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IFNG secretion" EXACT [GOC:TermGenie] is_a: GO:0032689 ! negative regulation of interferon-gamma production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1902713 ! regulation of interferon-gamma secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072643 ! interferon-gamma secretion relationship: negatively_regulates GO:0072643 ! interferon-gamma secretion created_by: als creation_date: 2014-02-21T16:34:29Z [Term] id: GO:1902715 name: positive regulation of interferon-gamma secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] synonym: "activation of IFN-gamma secretion" NARROW [GOC:TermGenie] synonym: "activation of IFNG secretion" NARROW [GOC:TermGenie] synonym: "activation of interferon-gamma secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "up regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IFN-gamma secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IFNG secretion" EXACT [GOC:TermGenie] synonym: "upregulation of interferon-gamma secretion" EXACT [GOC:TermGenie] is_a: GO:0032729 ! positive regulation of interferon-gamma production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1902713 ! regulation of interferon-gamma secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072643 ! interferon-gamma secretion relationship: positively_regulates GO:0072643 ! interferon-gamma secretion created_by: als creation_date: 2014-02-21T16:34:38Z [Term] id: GO:1902716 name: cell cortex of growing cell tip namespace: cellular_component def: "Any cell cortex that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:24146635] synonym: "cell cortex of growing cell end" EXACT [] is_a: GO:0051285 ! cell cortex of cell tip intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0035838 ! growing cell tip relationship: part_of GO:0035838 ! growing cell tip created_by: mah creation_date: 2014-02-24T15:46:57Z [Term] id: GO:1902717 name: obsolete sequestering of iron ion namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of iron ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "sequestering of iron ion" EXACT [] is_obsolete: true created_by: mrice creation_date: 2014-02-24T16:08:43Z [Term] id: GO:1902718 name: obsolete sequestering of copper ion namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of copper ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "sequestering of copper ion" EXACT [] is_obsolete: true created_by: mrice creation_date: 2014-02-24T16:08:53Z [Term] id: GO:1902719 name: obsolete extracellular sequestering of copper ion namespace: biological_process def: "OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "extracellular sequestering of copper ion" EXACT [] is_obsolete: true created_by: mrice creation_date: 2014-02-24T16:09:09Z [Term] id: GO:1902720 name: obsolete intracellular sequestering of copper ion namespace: biological_process def: "OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "intracellular sequestering of copper ion" EXACT [] is_obsolete: true created_by: mrice creation_date: 2014-02-24T16:09:18Z [Term] id: GO:1902721 name: negative regulation of prolactin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070459 ! prolactin secretion relationship: negatively_regulates GO:0070459 ! prolactin secretion created_by: mrice creation_date: 2014-02-24T16:09:28Z [Term] id: GO:1902722 name: positive regulation of prolactin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie] synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070459 ! prolactin secretion relationship: positively_regulates GO:0070459 ! prolactin secretion created_by: mrice creation_date: 2014-02-24T16:09:37Z [Term] id: GO:1902723 name: negative regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation is_a: GO:0014859 ! negative regulation of skeletal muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation relationship: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation created_by: mrice creation_date: 2014-02-24T16:09:46Z [Term] id: GO:1902724 name: positive regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of satellite cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of satellite cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation is_a: GO:0014858 ! positive regulation of skeletal muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation relationship: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation created_by: mrice creation_date: 2014-02-24T16:09:56Z [Term] id: GO:1902725 name: negative regulation of satellite cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of satellite cell differentiation" NARROW [GOC:TermGenie] is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation relationship: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation created_by: mrice creation_date: 2014-02-24T16:10:05Z [Term] id: GO:1902726 name: positive regulation of skeletal muscle satellite cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of satellite cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of satellite cell differentiation" EXACT [GOC:TermGenie] is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation relationship: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation created_by: mrice creation_date: 2014-02-24T16:10:14Z [Term] id: GO:1902727 name: negative regulation of growth factor dependent skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] is_a: GO:1902723 ! negative regulation of skeletal muscle satellite cell proliferation created_by: mrice creation_date: 2014-02-24T16:10:24Z [Term] id: GO:1902728 name: positive regulation of growth factor dependent skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] is_a: GO:1902724 ! positive regulation of skeletal muscle satellite cell proliferation created_by: mrice creation_date: 2014-02-24T16:10:33Z [Term] id: GO:1902729 name: negative regulation of proteoglycan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "down regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "downregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of proteoglycan anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan formation" NARROW [GOC:TermGenie] synonym: "inhibition of proteoglycan synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process relationship: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process created_by: mrice creation_date: 2014-02-24T16:10:43Z [Term] id: GO:1902730 name: positive regulation of proteoglycan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of proteoglycan anabolism" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan formation" NARROW [GOC:TermGenie] synonym: "activation of proteoglycan synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "up regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan formation" EXACT [GOC:TermGenie] synonym: "upregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030166 ! proteoglycan biosynthetic process relationship: positively_regulates GO:0030166 ! proteoglycan biosynthetic process created_by: mrice creation_date: 2014-02-24T16:10:52Z [Term] id: GO:1902731 name: negative regulation of chondrocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "down regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of chondrocyte proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of cartilage cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of chondrocyte cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of chondrocyte proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035988 ! chondrocyte proliferation relationship: negatively_regulates GO:0035988 ! chondrocyte proliferation created_by: mrice creation_date: 2014-02-24T16:11:02Z [Term] id: GO:1902732 name: positive regulation of chondrocyte proliferation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] synonym: "activation of cartilage cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of chondrocyte cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of chondrocyte proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of cartilage cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035988 ! chondrocyte proliferation relationship: positively_regulates GO:0035988 ! chondrocyte proliferation created_by: mrice creation_date: 2014-02-24T16:11:18Z [Term] id: GO:1902733 name: regulation of growth plate cartilage chondrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage" [GO_REF:0000058, GOC:TermGenie, PMID:23212449] is_a: GO:0046620 ! regulation of organ growth is_a: GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation relationship: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation created_by: mrice creation_date: 2014-02-24T16:11:28Z [Term] id: GO:1902734 name: regulation of receptor-mediated virion attachment to host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] synonym: "regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046813 ! receptor-mediated virion attachment to host cell relationship: regulates GO:0046813 ! receptor-mediated virion attachment to host cell created_by: als creation_date: 2014-02-25T12:25:56Z [Term] id: GO:1902735 name: negative regulation of receptor-mediated virion attachment to host cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] synonym: "down regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "down regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "down-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "downregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "downregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "inhibition of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie] synonym: "inhibition of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie] synonym: "negative regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell relationship: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell created_by: als creation_date: 2014-02-25T12:26:06Z [Term] id: GO:1902736 name: positive regulation of receptor-mediated virion attachment to host cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] synonym: "activation of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie] synonym: "activation of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie] synonym: "positive regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "up regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "up regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "up-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] synonym: "upregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] synonym: "upregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell relationship: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell created_by: als creation_date: 2014-02-25T12:26:16Z [Term] id: GO:1902737 name: dendritic filopodium namespace: cellular_component def: "A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines." [GO_REF:0000064, GOC:pad, GOC:PARL, GOC:TermGenie, http://en.wikipedia.org/wiki/Dendritic_filopodia, PMID:24464040] comment: Dendritic filopodia are generally less-well studied than dendritic spines because their transient nature makes them difficult to detect with traditional microscopy techniques, and because they are sometimes destroyed by sample preparation. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. synonym: "dendrite filopodium" EXACT [] is_a: GO:0030175 ! filopodium is_a: GO:0043005 ! neuron projection intersection_of: GO:0030175 ! filopodium intersection_of: part_of GO:0030425 ! dendrite relationship: part_of GO:0030425 ! dendrite created_by: pr creation_date: 2014-02-26T14:28:26Z [Term] id: GO:1902738 name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis created_by: mrice creation_date: 2014-02-26T15:36:15Z [Term] id: GO:1902739 name: regulation of interferon-alpha secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] synonym: "regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "regulation of IFNA secretion" EXACT [GOC:TermGenie] is_a: GO:0032647 ! regulation of interferon-alpha production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072642 ! interferon-alpha secretion relationship: regulates GO:0072642 ! interferon-alpha secretion created_by: mrice creation_date: 2014-02-26T22:13:20Z [Term] id: GO:1902740 name: negative regulation of interferon-alpha secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] synonym: "down regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "down regulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "down regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "downregulation of interferon-alpha secretion" EXACT [GOC:TermGenie] synonym: "inhibition of IFN-alpha secretion" NARROW [GOC:TermGenie] synonym: "inhibition of IFNA secretion" NARROW [GOC:TermGenie] synonym: "inhibition of interferon-alpha secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IFNA secretion" EXACT [GOC:TermGenie] is_a: GO:0032687 ! negative regulation of interferon-alpha production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1902739 ! regulation of interferon-alpha secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072642 ! interferon-alpha secretion relationship: negatively_regulates GO:0072642 ! interferon-alpha secretion created_by: mrice creation_date: 2014-02-26T22:13:30Z [Term] id: GO:1902741 name: positive regulation of interferon-alpha secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] synonym: "activation of IFN-alpha secretion" NARROW [GOC:TermGenie] synonym: "activation of IFNA secretion" NARROW [GOC:TermGenie] synonym: "activation of interferon-alpha secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "up regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IFN-alpha secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IFNA secretion" EXACT [GOC:TermGenie] synonym: "upregulation of interferon-alpha secretion" EXACT [GOC:TermGenie] is_a: GO:0032727 ! positive regulation of interferon-alpha production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1902739 ! regulation of interferon-alpha secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072642 ! interferon-alpha secretion relationship: positively_regulates GO:0072642 ! interferon-alpha secretion created_by: mrice creation_date: 2014-02-26T22:13:40Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: part_of GO:0048856 ! anatomical structure development relationship: part_of GO:0048856 ! anatomical structure development created_by: pr creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902743 name: regulation of lamellipodium organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097581 ! lamellipodium organization relationship: regulates GO:0097581 ! lamellipodium organization created_by: als creation_date: 2014-02-28T16:27:30Z [Term] id: GO:1902744 name: negative regulation of lamellipodium organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] synonym: "down regulation of lamellipodium organization" EXACT [GOC:TermGenie] synonym: "down-regulation of lamellipodium organization" EXACT [GOC:TermGenie] synonym: "downregulation of lamellipodium organization" EXACT [GOC:TermGenie] synonym: "inhibition of lamellipodium organization" NARROW [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:1902743 ! regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097581 ! lamellipodium organization relationship: negatively_regulates GO:0097581 ! lamellipodium organization created_by: als creation_date: 2014-02-28T16:27:39Z [Term] id: GO:1902745 name: positive regulation of lamellipodium organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] synonym: "activation of lamellipodium organization" NARROW [GOC:TermGenie] synonym: "up regulation of lamellipodium organization" EXACT [GOC:TermGenie] synonym: "up-regulation of lamellipodium organization" EXACT [GOC:TermGenie] synonym: "upregulation of lamellipodium organization" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:1902743 ! regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097581 ! lamellipodium organization relationship: positively_regulates GO:0097581 ! lamellipodium organization created_by: als creation_date: 2014-02-28T16:27:49Z [Term] id: GO:1902746 name: regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070306 ! lens fiber cell differentiation relationship: regulates GO:0070306 ! lens fiber cell differentiation created_by: mr creation_date: 2014-03-03T23:18:50Z [Term] id: GO:1902747 name: negative regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "down regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lens fiber cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of lens fibre cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902746 ! regulation of lens fiber cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070306 ! lens fiber cell differentiation relationship: negatively_regulates GO:0070306 ! lens fiber cell differentiation created_by: mr creation_date: 2014-03-03T23:19:32Z [Term] id: GO:1902748 name: positive regulation of lens fiber cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] synonym: "activation of lens fiber cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of lens fibre cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902746 ! regulation of lens fiber cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070306 ! lens fiber cell differentiation relationship: positively_regulates GO:0070306 ! lens fiber cell differentiation created_by: mr creation_date: 2014-03-03T23:20:12Z [Term] id: GO:1902749 name: regulation of cell cycle G2/M phase transition namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044839 ! cell cycle G2/M phase transition relationship: regulates GO:0044839 ! cell cycle G2/M phase transition created_by: jl creation_date: 2014-03-05T15:38:15Z [Term] id: GO:1902750 name: negative regulation of cell cycle G2/M phase transition namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] synonym: "down regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle G2/M phase transition" NARROW [GOC:TermGenie] is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition relationship: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition created_by: jl creation_date: 2014-03-05T15:38:21Z [Term] id: GO:1902751 name: positive regulation of cell cycle G2/M phase transition namespace: biological_process def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] synonym: "activation of cell cycle G2/M phase transition" NARROW [GOC:TermGenie] synonym: "up regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044839 ! cell cycle G2/M phase transition relationship: positively_regulates GO:0044839 ! cell cycle G2/M phase transition created_by: jl creation_date: 2014-03-05T15:38:27Z [Term] id: GO:1902752 name: regulation of renal amino acid absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990297 ! renal amino acid absorption relationship: regulates GO:1990297 ! renal amino acid absorption created_by: hjd creation_date: 2014-03-05T15:43:55Z [Term] id: GO:1902753 name: negative regulation of renal amino acid absorption namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] synonym: "down regulation of renal amino acid absorption" EXACT [GOC:TermGenie] synonym: "down-regulation of renal amino acid absorption" EXACT [GOC:TermGenie] synonym: "downregulation of renal amino acid absorption" EXACT [GOC:TermGenie] synonym: "inhibition of renal amino acid absorption" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902752 ! regulation of renal amino acid absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990297 ! renal amino acid absorption relationship: negatively_regulates GO:1990297 ! renal amino acid absorption created_by: hjd creation_date: 2014-03-05T15:44:01Z [Term] id: GO:1902754 name: positive regulation of renal amino acid absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] synonym: "activation of renal amino acid absorption" NARROW [GOC:TermGenie] synonym: "up regulation of renal amino acid absorption" EXACT [GOC:TermGenie] synonym: "up-regulation of renal amino acid absorption" EXACT [GOC:TermGenie] synonym: "upregulation of renal amino acid absorption" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902752 ! regulation of renal amino acid absorption intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990297 ! renal amino acid absorption relationship: positively_regulates GO:1990297 ! renal amino acid absorption created_by: hjd creation_date: 2014-03-05T15:44:07Z [Term] id: GO:1902755 name: sulfurated eukaryotic molybdenum cofactor(2-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600] synonym: "sulfurated eukaryotic molybdenum cofactor(2-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process created_by: dph creation_date: 2014-03-05T23:29:13Z [Term] id: GO:1902756 name: sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600] synonym: "sulfurated eukaryotic molybdenum cofactor(2-) anabolism" EXACT [GOC:TermGenie] synonym: "sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis" EXACT [GOC:TermGenie] synonym: "sulfurated eukaryotic molybdenum cofactor(2-) formation" EXACT [GOC:TermGenie] synonym: "sulfurated eukaryotic molybdenum cofactor(2-) synthesis" EXACT [GOC:TermGenie] xref: MetaCyc:PWY-6476 xref: Reactome:R-HSA-947581 is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process is_a: GO:1902755 ! sulfurated eukaryotic molybdenum cofactor(2-) metabolic process relationship: has_part GO:0008265 ! Mo-molybdopterin cofactor sulfurase activity created_by: dph creation_date: 2014-03-05T23:29:20Z [Term] id: GO:1902757 name: bis(molybdopterin guanine dinucleotide)molybdenum metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] synonym: "bis(molybdopterin guanine dinucleotide)molybdenum metabolism" EXACT [GOC:TermGenie] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process created_by: dph creation_date: 2014-03-06T13:58:10Z [Term] id: GO:1902758 name: bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process namespace: biological_process alt_id: GO:0061600 def: "The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] synonym: "bis(molybdopterin guanine dinucleotide)molybdenum anabolism" EXACT [GOC:TermGenie] synonym: "bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis" EXACT [GOC:TermGenie] synonym: "bis(molybdopterin guanine dinucleotide)molybdenum formation" EXACT [GOC:TermGenie] synonym: "bis(molybdopterin guanine dinucleotide)molybdenum synthesis" EXACT [GOC:TermGenie] synonym: "bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process" EXACT [] xref: MetaCyc:PWY-5964 is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:1902757 ! bis(molybdopterin guanine dinucleotide)molybdenum metabolic process relationship: has_part GO:0061603 ! molybdenum cofactor guanylyltransferase activity created_by: dph creation_date: 2014-03-06T13:58:18Z [Term] id: GO:1902759 name: Mo(VI)-molybdopterin cytosine dinucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] synonym: "Mo(VI)-molybdopterin cytosine dinucleotide metabolism" EXACT [GOC:TermGenie] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process created_by: dph creation_date: 2014-03-06T14:00:31Z [Term] id: GO:1902760 name: Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process namespace: biological_process alt_id: GO:0061601 def: "The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] synonym: "Mo(VI)-molybdopterin cytosine dinucleotide anabolism" EXACT [GOC:TermGenie] synonym: "Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis" EXACT [GOC:TermGenie] synonym: "Mo(VI)-molybdopterin cytosine dinucleotide formation" EXACT [GOC:TermGenie] synonym: "Mo(VI)-molybdopterin cytosine dinucleotide synthesis" EXACT [GOC:TermGenie] synonym: "Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process" EXACT [] xref: MetaCyc:PWY-6476 is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:1902759 ! Mo(VI)-molybdopterin cytosine dinucleotide metabolic process relationship: has_part GO:0061602 ! molybdenum cofactor cytidylyltransferase activity created_by: dph creation_date: 2014-03-06T14:00:43Z [Term] id: GO:1902761 name: positive regulation of chondrocyte development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0032332 ! positive regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002063 ! chondrocyte development relationship: positively_regulates GO:0002063 ! chondrocyte development created_by: mr creation_date: 2014-03-07T17:45:55Z [Term] id: GO:1902762 name: regulation of embryonic skeletal joint development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072498 ! embryonic skeletal joint development relationship: regulates GO:0072498 ! embryonic skeletal joint development created_by: mr creation_date: 2014-03-07T17:46:01Z [Term] id: GO:1902763 name: negative regulation of embryonic skeletal joint development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "down regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] synonym: "inhibition of embryonic skeletal joint development" NARROW [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1902762 ! regulation of embryonic skeletal joint development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072498 ! embryonic skeletal joint development relationship: negatively_regulates GO:0072498 ! embryonic skeletal joint development created_by: mr creation_date: 2014-03-07T17:46:07Z [Term] id: GO:1902764 name: positive regulation of embryonic skeletal joint development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "activation of embryonic skeletal joint development" NARROW [GOC:TermGenie] synonym: "up regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1902762 ! regulation of embryonic skeletal joint development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072498 ! embryonic skeletal joint development relationship: positively_regulates GO:0072498 ! embryonic skeletal joint development created_by: mr creation_date: 2014-03-07T17:46:13Z [Term] id: GO:1902766 name: skeletal muscle satellite cell migration namespace: biological_process def: "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells." [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936] is_a: GO:0016477 ! cell migration created_by: mr creation_date: 2014-03-10T15:20:28Z [Term] id: GO:1902767 name: isoprenoid biosynthetic process via mevalonate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:11078528] synonym: "isoprenoid anabolism via mevalonate" EXACT [GOC:TermGenie] synonym: "isoprenoid biosynthesis via mevalonate" EXACT [GOC:TermGenie] synonym: "isoprenoid formation via mevalonate" EXACT [GOC:TermGenie] synonym: "isoprenoid synthesis via mevalonate" EXACT [GOC:TermGenie] is_a: GO:0008299 ! isoprenoid biosynthetic process created_by: tt creation_date: 2014-03-10T23:45:10Z [Term] id: GO:1902768 name: isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:23746261] synonym: "isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] synonym: "isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] synonym: "isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] synonym: "isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] is_a: GO:0008299 ! isoprenoid biosynthetic process created_by: tt creation_date: 2014-03-11T00:09:55Z [Term] id: GO:1902769 name: regulation of choline O-acetyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] synonym: "regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004102 ! choline O-acetyltransferase activity relationship: regulates GO:0004102 ! choline O-acetyltransferase activity created_by: mr creation_date: 2014-03-11T18:54:26Z [Term] id: GO:1902770 name: negative regulation of choline O-acetyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] synonym: "down regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "down regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "downregulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CHOACTase activity" NARROW [GOC:TermGenie] synonym: "inhibition of choline acetylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of choline acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of choline O-acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004102 ! choline O-acetyltransferase activity relationship: negatively_regulates GO:0004102 ! choline O-acetyltransferase activity created_by: mr creation_date: 2014-03-11T18:56:50Z [Term] id: GO:1902771 name: positive regulation of choline O-acetyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] synonym: "activation of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CHOACTase activity" NARROW [GOC:TermGenie] synonym: "activation of choline acetylase activity" NARROW [GOC:TermGenie] synonym: "activation of choline acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of choline O-acetyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "up regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CHOACTase activity" EXACT [GOC:TermGenie] synonym: "upregulation of choline acetylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004102 ! choline O-acetyltransferase activity relationship: positively_regulates GO:0004102 ! choline O-acetyltransferase activity created_by: mr creation_date: 2014-03-11T18:58:39Z [Term] id: GO:1902772 name: positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway namespace: biological_process def: "Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:18406331] synonym: "activation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0070299 ! positive regulation of phosphorelay signal transduction system intersection_of: GO:0070299 ! positive regulation of phosphorelay signal transduction system intersection_of: part_of GO:0071588 ! hydrogen peroxide mediated signaling pathway relationship: part_of GO:0071588 ! hydrogen peroxide mediated signaling pathway created_by: al creation_date: 2014-03-17T11:42:08Z [Term] id: GO:1902773 name: GTPase activator complex namespace: cellular_component def: "A protein complex which is capable of GTPase activator activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187] comment: An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay). is_a: GO:0150005 ! enzyme activator complex created_by: bhm creation_date: 2014-03-17T14:26:08Z [Term] id: GO:1902774 name: late endosome to lysosome transport namespace: biological_process def: "The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442] comment: an example of this is snapin in mouse (Q9Z266) in PMID:20920792 inferred from mutant phenotype synonym: "prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie] is_a: GO:0007041 ! lysosomal transport created_by: pad creation_date: 2014-03-17T16:32:36Z [Term] id: GO:1902775 name: mitochondrial large ribosomal subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665] synonym: "39S ribosomal subunit, mitochondrial assembly" NARROW [GOC:TermGenie] synonym: "39S ribosomal subunit, mitochondrial formation" NARROW [GOC:TermGenie] synonym: "mitochondrial large ribosomal subunit formation" EXACT [GOC:TermGenie] is_a: GO:0000027 ! ribosomal large subunit assembly relationship: part_of GO:0061668 ! mitochondrial ribosome assembly created_by: mcc creation_date: 2014-03-18T14:32:19Z [Term] id: GO:1902776 name: 6-sulfoquinovose(1-) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506] synonym: "6-sulfoquinovose(1-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: dph creation_date: 2014-03-18T17:45:56Z [Term] id: GO:1902777 name: 6-sulfoquinovose(1-) catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506] synonym: "6-sulfoquinovose(1-) breakdown" EXACT [GOC:TermGenie] synonym: "6-sulfoquinovose(1-) catabolism" EXACT [GOC:TermGenie] synonym: "6-sulfoquinovose(1-) degradation" EXACT [GOC:TermGenie] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1902776 ! 6-sulfoquinovose(1-) metabolic process created_by: dph creation_date: 2014-03-18T17:46:03Z [Term] id: GO:1902778 name: response to alkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995] is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-03-21T03:17:21Z [Term] id: GO:1902779 name: cellular response to alkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T03:18:04Z [Term] id: GO:1902780 name: response to nonane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739] is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T03:24:50Z [Term] id: GO:1902781 name: cellular response to nonane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739] is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902780 ! response to nonane created_by: tt creation_date: 2014-03-21T03:25:32Z [Term] id: GO:1902782 name: response to decane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T12:50:08Z [Term] id: GO:1902783 name: cellular response to decane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902782 ! response to decane created_by: tt creation_date: 2014-03-21T12:50:14Z [Term] id: GO:1902784 name: response to undecane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T13:39:06Z [Term] id: GO:1902785 name: cellular response to undecane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902784 ! response to undecane created_by: tt creation_date: 2014-03-21T13:39:24Z [Term] id: GO:1902786 name: response to dodecane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T13:41:36Z [Term] id: GO:1902787 name: cellular response to dodecane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902786 ! response to dodecane created_by: tt creation_date: 2014-03-21T13:41:52Z [Term] id: GO:1902788 name: response to isooctane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] is_a: GO:0009636 ! response to toxic substance is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T20:52:51Z [Term] id: GO:1902789 name: cellular response to isooctane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902788 ! response to isooctane created_by: tt creation_date: 2014-03-21T20:52:58Z [Term] id: GO:1902790 name: undecan-2-one metabolic process namespace: biological_process def: "The chemical reactions and pathways involving undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559] synonym: "undecan-2-one metabolism" EXACT [GOC:TermGenie] is_a: GO:0042180 ! cellular ketone metabolic process created_by: tt creation_date: 2014-03-22T02:13:01Z [Term] id: GO:1902791 name: undecan-2-one biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559] synonym: "undecan-2-one anabolism" EXACT [GOC:TermGenie] synonym: "undecan-2-one biosynthesis" EXACT [GOC:TermGenie] synonym: "undecan-2-one formation" EXACT [GOC:TermGenie] synonym: "undecan-2-one synthesis" EXACT [GOC:TermGenie] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1902790 ! undecan-2-one metabolic process created_by: tt creation_date: 2014-03-22T02:13:07Z [Term] id: GO:1902792 name: pyrroline-5-carboxylate reductase complex namespace: cellular_component def: "A protein complex which is capable of pyrroline-5-carboxylate reductase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:2722838] comment: An example of this is PYCR1 in human (P32322) in PMID:2722838 (inferred from direct assay). is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2014-03-24T09:55:22Z [Term] id: GO:1902793 name: glutamate decarboxylase complex namespace: cellular_component def: "A protein complex which is capable of glutamate decarboxylase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17384644] comment: An example of this is GAD1 in human (Q99259) in PMID:17384644 (inferred from direct assay). is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2014-03-24T10:59:45Z [Term] id: GO:1902794 name: heterochromatin island assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a heterochromatin island." [GO_REF:0000079, GOC:TermGenie, PMID:24210919] synonym: "heterochromatin island formation" EXACT [GOC:TermGenie] is_a: GO:0031507 ! heterochromatin assembly created_by: mah creation_date: 2014-03-24T12:46:49Z [Term] id: GO:1902795 name: heterochromatin domain assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a heterochromatin domain." [GO_REF:0000079, GOC:TermGenie, PMID:24210919] synonym: "heterochromatin domain formation" EXACT [GOC:TermGenie] synonym: "HOOD assembly" EXACT [GOC:TermGenie] synonym: "HOOD formation" EXACT [GOC:TermGenie] is_a: GO:0031507 ! heterochromatin assembly created_by: mah creation_date: 2014-03-24T12:46:56Z [Term] id: GO:1902796 name: regulation of snoRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903323 ! regulation of snoRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043144 ! snoRNA processing relationship: regulates GO:0043144 ! snoRNA processing created_by: mah creation_date: 2014-03-24T12:47:02Z [Term] id: GO:1902797 name: negative regulation of snoRNA processing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] synonym: "down regulation of snoRNA processing" EXACT [GOC:TermGenie] synonym: "down-regulation of snoRNA processing" EXACT [GOC:TermGenie] synonym: "downregulation of snoRNA processing" EXACT [GOC:TermGenie] synonym: "inhibition of snoRNA processing" NARROW [GOC:TermGenie] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:1902796 ! regulation of snoRNA processing is_a: GO:1903324 ! negative regulation of snoRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043144 ! snoRNA processing relationship: negatively_regulates GO:0043144 ! snoRNA processing created_by: mah creation_date: 2014-03-24T12:47:08Z [Term] id: GO:1902798 name: positive regulation of snoRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] synonym: "activation of snoRNA processing" NARROW [GOC:TermGenie] synonym: "up regulation of snoRNA processing" EXACT [GOC:TermGenie] synonym: "up-regulation of snoRNA processing" EXACT [GOC:TermGenie] synonym: "upregulation of snoRNA processing" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1902796 ! regulation of snoRNA processing is_a: GO:1903325 ! positive regulation of snoRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043144 ! snoRNA processing relationship: positively_regulates GO:0043144 ! snoRNA processing created_by: mah creation_date: 2014-03-24T12:47:20Z [Term] id: GO:1902799 name: regulation of phosphodiesterase I activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510] synonym: "regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "regulation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "regulation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of PDE I activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphodiesterase activity" BROAD [GOC:TermGenie] is_a: GO:1905777 ! regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004528 ! phosphodiesterase I activity relationship: regulates GO:0004528 ! phosphodiesterase I activity created_by: al creation_date: 2014-03-25T08:55:48Z [Term] id: GO:1902800 name: positive regulation of phosphodiesterase I activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510] synonym: "activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" NARROW [GOC:TermGenie] synonym: "activation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "activation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "activation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "activation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "activation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "activation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "activation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "activation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "activation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "activation of nucleotide pyrophosphatase/phosphodiesterase I activity" NARROW [GOC:TermGenie] synonym: "activation of oligonucleate 5'-nucleotidohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of orthophosphoric diester phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of PDE I activity" NARROW [GOC:TermGenie] synonym: "activation of phosphodiesterase I activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "positive regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "positive regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PDE I activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "up regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up regulation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "up regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PDE I activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "up-regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "up-regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PDE I activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'-NPDase activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'-PDase activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'-PDE activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5'NPDE activity" RELATED [GOC:TermGenie] synonym: "upregulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] synonym: "upregulation of exonuclease I activity" RELATED [GOC:TermGenie] synonym: "upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] synonym: "upregulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PDE I activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] is_a: GO:1902799 ! regulation of phosphodiesterase I activity is_a: GO:1905779 ! positive regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004528 ! phosphodiesterase I activity relationship: positively_regulates GO:0004528 ! phosphodiesterase I activity created_by: al creation_date: 2014-03-25T08:55:54Z [Term] id: GO:1902801 name: regulation of heterochromatin island assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heterochromatin island assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] synonym: "regulation of heterochromatin island formation" EXACT [GOC:TermGenie] is_a: GO:0031445 ! regulation of heterochromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902794 ! heterochromatin island assembly relationship: regulates GO:1902794 ! heterochromatin island assembly created_by: mah creation_date: 2014-03-25T14:44:48Z [Term] id: GO:1902802 name: regulation of heterochromatin domain assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heterochromatin domain assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] synonym: "regulation of heterochromatin domain formation" EXACT [GOC:TermGenie] synonym: "regulation of HOOD assembly" EXACT [GOC:TermGenie] synonym: "regulation of HOOD formation" EXACT [GOC:TermGenie] is_a: GO:0031445 ! regulation of heterochromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902795 ! heterochromatin domain assembly relationship: regulates GO:1902795 ! heterochromatin domain assembly created_by: mah creation_date: 2014-03-25T14:44:54Z [Term] id: GO:1902803 name: regulation of synaptic vesicle transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] synonym: "regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048489 ! synaptic vesicle transport relationship: regulates GO:0048489 ! synaptic vesicle transport created_by: kmv creation_date: 2014-03-25T14:56:34Z [Term] id: GO:1902804 name: negative regulation of synaptic vesicle transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] synonym: "down regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "down regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "down regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "downregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "downregulation of synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "inhibition of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "inhibition of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "inhibition of synaptic vesicle transport" NARROW [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1902803 ! regulation of synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048489 ! synaptic vesicle transport relationship: negatively_regulates GO:0048489 ! synaptic vesicle transport created_by: kmv creation_date: 2014-03-25T14:56:40Z [Term] id: GO:1902805 name: positive regulation of synaptic vesicle transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] synonym: "activation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "activation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "activation of synaptic vesicle transport" NARROW [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "up regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "up regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "up regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle fission" RELATED [GOC:TermGenie] synonym: "upregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] synonym: "upregulation of synaptic vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1902803 ! regulation of synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048489 ! synaptic vesicle transport relationship: positively_regulates GO:0048489 ! synaptic vesicle transport created_by: kmv creation_date: 2014-03-25T14:56:46Z [Term] id: GO:1902806 name: regulation of cell cycle G1/S phase transition namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044843 ! cell cycle G1/S phase transition relationship: regulates GO:0044843 ! cell cycle G1/S phase transition created_by: jl creation_date: 2014-03-26T16:36:14Z [Term] id: GO:1902807 name: negative regulation of cell cycle G1/S phase transition namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle G1/S phase transition" NARROW [GOC:TermGenie] is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition relationship: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition created_by: jl creation_date: 2014-03-26T16:36:20Z [Term] id: GO:1902808 name: positive regulation of cell cycle G1/S phase transition namespace: biological_process def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of cell cycle G1/S phase transition" NARROW [GOC:TermGenie] synonym: "up regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044843 ! cell cycle G1/S phase transition relationship: positively_regulates GO:0044843 ! cell cycle G1/S phase transition created_by: jl creation_date: 2014-03-26T16:36:32Z [Term] id: GO:1902809 name: regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098528 ! skeletal muscle fiber differentiation relationship: regulates GO:0098528 ! skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:26Z [Term] id: GO:1902810 name: negative regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation relationship: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:32Z [Term] id: GO:1902811 name: positive regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation relationship: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation created_by: mr creation_date: 2014-03-26T21:18:38Z [Term] id: GO:1902812 name: regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] synonym: "regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: mr creation_date: 2014-03-26T21:18:44Z [Term] id: GO:1902813 name: negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] synonym: "down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie] synonym: "inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] is_a: GO:0030514 ! negative regulation of BMP signaling pathway is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: negatively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: mr creation_date: 2014-03-26T21:18:50Z [Term] id: GO:1902814 name: positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] synonym: "activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie] synonym: "activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] synonym: "positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] synonym: "upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] synonym: "upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] is_a: GO:0030513 ! positive regulation of BMP signaling pathway is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry relationship: positively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry created_by: mr creation_date: 2014-03-26T21:18:56Z [Term] id: GO:1902815 name: N,N'-diacetylchitobiose import namespace: biological_process def: "The directed movement of N,N'-diacetylchitobiose into a cell or organelle." [GO_REF:0000073, GOC:am, GOC:TermGenie, PMID:9405618] is_a: GO:1901264 ! carbohydrate derivative transport created_by: tb creation_date: 2014-03-27T20:58:58Z [Term] id: GO:1902816 name: regulation of protein localization to microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035372 ! protein localization to microtubule relationship: regulates GO:0035372 ! protein localization to microtubule created_by: tb creation_date: 2014-03-27T22:07:12Z [Term] id: GO:1902817 name: negative regulation of protein localization to microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:1902816 ! regulation of protein localization to microtubule is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035372 ! protein localization to microtubule relationship: negatively_regulates GO:0035372 ! protein localization to microtubule created_by: tb creation_date: 2014-03-27T22:07:18Z [Term] id: GO:1902818 name: ethyl acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] synonym: "ethyl acetate metabolism" EXACT [GOC:TermGenie] synonym: "ethyl ethanoate metabolic process" EXACT [] is_a: GO:1900619 ! acetate ester metabolic process created_by: tt creation_date: 2014-03-30T20:26:47Z [Term] id: GO:1902819 name: ethyl acetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] synonym: "ethyl acetate anabolism" EXACT [GOC:TermGenie] synonym: "ethyl acetate biosynthesis" EXACT [GOC:TermGenie] synonym: "ethyl acetate formation" EXACT [GOC:TermGenie] synonym: "ethyl acetate synthesis" EXACT [GOC:TermGenie] synonym: "ethyl ethanoate biosynthetic process" EXACT [] is_a: GO:1900620 ! acetate ester biosynthetic process is_a: GO:1902818 ! ethyl acetate metabolic process created_by: tt creation_date: 2014-03-30T20:26:53Z [Term] id: GO:1902820 name: 1-undecene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] synonym: "1-undecene metabolism" EXACT [GOC:TermGenie] is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2014-03-31T02:50:48Z [Term] id: GO:1902821 name: 1-undecene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] synonym: "1-undecene anabolism" EXACT [GOC:TermGenie] synonym: "1-undecene biosynthesis" EXACT [GOC:TermGenie] synonym: "1-undecene formation" EXACT [GOC:TermGenie] synonym: "1-undecene synthesis" EXACT [GOC:TermGenie] is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1902820 ! 1-undecene metabolic process created_by: tt creation_date: 2014-03-31T02:51:19Z [Term] id: GO:1902822 name: regulation of late endosome to lysosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] synonym: "regulation of prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie] is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902774 ! late endosome to lysosome transport relationship: regulates GO:1902774 ! late endosome to lysosome transport created_by: pad creation_date: 2014-03-31T10:08:38Z [Term] id: GO:1902823 name: negative regulation of late endosome to lysosome transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] synonym: "down regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] synonym: "down-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] synonym: "downregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] synonym: "inhibition of late endosome to lysosome transport" NARROW [GOC:TermGenie] is_a: GO:1902822 ! regulation of late endosome to lysosome transport is_a: GO:1903336 ! negative regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902774 ! late endosome to lysosome transport relationship: negatively_regulates GO:1902774 ! late endosome to lysosome transport created_by: pad creation_date: 2014-03-31T10:08:51Z [Term] id: GO:1902824 name: positive regulation of late endosome to lysosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] synonym: "activation of late endosome to lysosome transport" NARROW [GOC:TermGenie] synonym: "up regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] synonym: "up-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] synonym: "upregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] is_a: GO:1902822 ! regulation of late endosome to lysosome transport is_a: GO:1903337 ! positive regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902774 ! late endosome to lysosome transport relationship: positively_regulates GO:1902774 ! late endosome to lysosome transport created_by: pad creation_date: 2014-03-31T10:08:57Z [Term] id: GO:1902829 name: regulation of spinal cord association neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0021527 ! spinal cord association neuron differentiation relationship: regulates GO:0021527 ! spinal cord association neuron differentiation created_by: mr creation_date: 2014-03-31T17:10:55Z [Term] id: GO:1902830 name: negative regulation of spinal cord association neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "down regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of spinal cord association neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation relationship: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation created_by: mr creation_date: 2014-03-31T17:11:55Z [Term] id: GO:1902831 name: positive regulation of spinal cord association neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "activation of spinal cord association neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0021527 ! spinal cord association neuron differentiation relationship: positively_regulates GO:0021527 ! spinal cord association neuron differentiation created_by: mr creation_date: 2014-03-31T17:12:38Z [Term] id: GO:1902832 name: negative regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "down regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "inhibition of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord relationship: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord created_by: mr creation_date: 2014-03-31T17:42:50Z [Term] id: GO:1902833 name: positive regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] synonym: "activation of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord relationship: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord created_by: mr creation_date: 2014-03-31T17:43:33Z [Term] id: GO:1902834 name: regulation of proline import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] synonym: "regulation of proline import into cell" EXACT [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0070881 ! regulation of proline transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905647 ! proline import across plasma membrane relationship: regulates GO:1905647 ! proline import across plasma membrane created_by: mah creation_date: 2014-04-01T13:44:00Z [Term] id: GO:1902835 name: negative regulation of proline import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] synonym: "down regulation of proline import into cell" EXACT [GOC:TermGenie] synonym: "down-regulation of proline import into cell" EXACT [GOC:TermGenie] synonym: "downregulation of proline import into cell" EXACT [GOC:TermGenie] synonym: "inhibition of proline import into cell" NARROW [GOC:TermGenie] synonym: "negative regulation of proline import into cell" EXACT [] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1902834 ! regulation of proline import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905647 ! proline import across plasma membrane relationship: negatively_regulates GO:1905647 ! proline import across plasma membrane created_by: mah creation_date: 2014-04-01T13:44:06Z [Term] id: GO:1902836 name: positive regulation of proline import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] synonym: "activation of proline import into cell" NARROW [GOC:TermGenie] synonym: "positive regulation of proline import into cell" EXACT [] synonym: "up regulation of proline import into cell" EXACT [GOC:TermGenie] synonym: "up-regulation of proline import into cell" EXACT [GOC:TermGenie] synonym: "upregulation of proline import into cell" EXACT [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1902834 ! regulation of proline import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905647 ! proline import across plasma membrane relationship: positively_regulates GO:1905647 ! proline import across plasma membrane created_by: mah creation_date: 2014-04-01T13:44:20Z [Term] id: GO:1902838 name: regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie] synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie] synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030473 ! nuclear migration along microtubule relationship: regulates GO:0030473 ! nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:23Z [Term] id: GO:1902839 name: negative regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030473 ! nuclear migration along microtubule relationship: negatively_regulates GO:0030473 ! nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:29Z [Term] id: GO:1902840 name: positive regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030473 ! nuclear migration along microtubule relationship: positively_regulates GO:0030473 ! nuclear migration along microtubule created_by: vw creation_date: 2014-04-01T13:50:35Z [Term] id: GO:1902841 name: regulation of netrin-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] synonym: "regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038007 ! netrin-activated signaling pathway relationship: regulates GO:0038007 ! netrin-activated signaling pathway created_by: kmv creation_date: 2014-04-01T15:24:46Z [Term] id: GO:1902842 name: negative regulation of netrin-activated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] synonym: "down regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "down regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "downregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of netrin signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of netrin-activated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of netrin-activated signalling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of netrin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902841 ! regulation of netrin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038007 ! netrin-activated signaling pathway relationship: negatively_regulates GO:0038007 ! netrin-activated signaling pathway created_by: kmv creation_date: 2014-04-01T15:25:33Z [Term] id: GO:1902843 name: positive regulation of netrin-activated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] synonym: "activation of netrin signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of netrin-activated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of netrin-activated signalling pathway" NARROW [GOC:TermGenie] synonym: "activation of netrin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "up regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of netrin signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] synonym: "upregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902841 ! regulation of netrin-activated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038007 ! netrin-activated signaling pathway relationship: positively_regulates GO:0038007 ! netrin-activated signaling pathway created_by: kmv creation_date: 2014-04-01T15:25:53Z [Term] id: GO:1902844 name: positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway namespace: biological_process def: "A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation." [GO_REF:0000063, GOC:mr, GOC:TermGenie, PMID:11262869] synonym: "activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation intersection_of: GO:0050789 ! regulation of biological process intersection_of: negatively_regulates GO:0100067 ! positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway relationship: negatively_regulates GO:0100067 ! positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway created_by: mr creation_date: 2014-04-01T15:28:30Z [Term] id: GO:1902845 name: negative regulation of mitotic spindle elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic spindle elongation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle elongation during mitosis" NARROW [GOC:TermGenie] synonym: "negative regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000022 ! mitotic spindle elongation relationship: negatively_regulates GO:0000022 ! mitotic spindle elongation created_by: vw creation_date: 2014-04-02T08:43:28Z [Term] id: GO:1902846 name: positive regulation of mitotic spindle elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of mitotic spindle elongation" NARROW [GOC:TermGenie] synonym: "activation of spindle elongation during mitosis" NARROW [GOC:TermGenie] synonym: "positive regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "up regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "upregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:0110028 ! positive regulation of mitotic spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000022 ! mitotic spindle elongation relationship: positively_regulates GO:0000022 ! mitotic spindle elongation created_by: vw creation_date: 2014-04-02T08:43:34Z [Term] id: GO:1902847 name: regulation of neuronal signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0023041 ! neuronal signal transduction relationship: regulates GO:0023041 ! neuronal signal transduction created_by: sjp creation_date: 2014-04-02T10:11:12Z [Term] id: GO:1902848 name: negative regulation of neuronal signal transduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] synonym: "down regulation of neuronal signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of neuronal signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of neuronal signal transduction" EXACT [GOC:TermGenie] synonym: "inhibition of neuronal signal transduction" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902847 ! regulation of neuronal signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0023041 ! neuronal signal transduction relationship: negatively_regulates GO:0023041 ! neuronal signal transduction created_by: sjp creation_date: 2014-04-02T10:11:18Z [Term] id: GO:1902849 name: positive regulation of neuronal signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] synonym: "activation of neuronal signal transduction" NARROW [GOC:TermGenie] synonym: "up regulation of neuronal signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of neuronal signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of neuronal signal transduction" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902847 ! regulation of neuronal signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0023041 ! neuronal signal transduction relationship: positively_regulates GO:0023041 ! neuronal signal transduction created_by: sjp creation_date: 2014-04-02T10:11:24Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: vw creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902852 name: regulation of nuclear migration during mitotic telophase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090561 ! nuclear migration during mitotic telophase relationship: regulates GO:0090561 ! nuclear migration during mitotic telophase created_by: vw creation_date: 2014-04-02T15:35:34Z [Term] id: GO:1902853 name: negative regulation of nuclear migration during mitotic telophase namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] synonym: "inhibition of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie] is_a: GO:1902839 ! negative regulation of nuclear migration along microtubule is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase relationship: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase created_by: vw creation_date: 2014-04-02T15:35:56Z [Term] id: GO:1902854 name: positive regulation of nuclear migration during mitotic telophase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie] synonym: "up regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] is_a: GO:1902840 ! positive regulation of nuclear migration along microtubule is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase relationship: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase created_by: vw creation_date: 2014-04-02T15:36:06Z [Term] id: GO:1902855 name: regulation of non-motile cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "regulation of nonmotile primary cilium assembly" RELATED [] synonym: "regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:1902017 ! regulation of cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905515 ! non-motile cilium assembly relationship: regulates GO:1905515 ! non-motile cilium assembly created_by: kmv creation_date: 2014-04-02T15:41:57Z [Term] id: GO:1902856 name: negative regulation of non-motile cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "down regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of immotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "inhibition of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of sensory cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nonmotile primary cilium assembly" RELATED [] synonym: "negative regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:1902018 ! negative regulation of cilium assembly is_a: GO:1902855 ! regulation of non-motile cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905515 ! non-motile cilium assembly relationship: negatively_regulates GO:1905515 ! non-motile cilium assembly created_by: kmv creation_date: 2014-04-02T15:42:17Z [Term] id: GO:1902857 name: positive regulation of non-motile cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] synonym: "activation of immotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "activation of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of sensory cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nonmotile primary cilium assembly" RELATED [] synonym: "positive regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of sensory cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0045724 ! positive regulation of cilium assembly is_a: GO:1902855 ! regulation of non-motile cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905515 ! non-motile cilium assembly relationship: positively_regulates GO:1905515 ! non-motile cilium assembly created_by: kmv creation_date: 2014-04-02T15:42:31Z [Term] id: GO:1902858 name: propionyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] synonym: "propionyl-CoA metabolism" EXACT [GOC:TermGenie] is_a: GO:0035337 ! fatty-acyl-CoA metabolic process created_by: tt creation_date: 2014-04-03T03:10:17Z [Term] id: GO:1902859 name: propionyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] synonym: "propionyl-CoA breakdown" EXACT [GOC:TermGenie] synonym: "propionyl-CoA catabolism" EXACT [GOC:TermGenie] synonym: "propionyl-CoA degradation" EXACT [GOC:TermGenie] is_a: GO:0036115 ! fatty-acyl-CoA catabolic process is_a: GO:1902858 ! propionyl-CoA metabolic process created_by: tt creation_date: 2014-04-03T03:10:23Z [Term] id: GO:1902860 name: propionyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] synonym: "propionyl-CoA anabolism" EXACT [GOC:TermGenie] synonym: "propionyl-CoA biosynthesis" EXACT [GOC:TermGenie] synonym: "propionyl-CoA formation" EXACT [GOC:TermGenie] synonym: "propionyl-CoA synthesis" EXACT [GOC:TermGenie] is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process is_a: GO:1902858 ! propionyl-CoA metabolic process created_by: tt creation_date: 2014-04-03T03:10:29Z [Term] id: GO:1902862 name: obsolete glycerol catabolic process to glycerone phosphate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycerol to glycerone phosphate." [GO_REF:0000093, GOC:dph, GOC:TermGenie, ISBN:0201090910] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "glycerol breakdown to glycerone phosphate" EXACT [GOC:TermGenie] synonym: "glycerol catabolic process to glycerone phosphate" EXACT [] synonym: "glycerol catabolism to glycerone phosphate" EXACT [GOC:TermGenie] synonym: "glycerol degradation to glycerone phosphate" EXACT [GOC:TermGenie] is_obsolete: true created_by: dph creation_date: 2014-04-03T14:42:01Z [Term] id: GO:1902863 name: regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031076 ! embryonic camera-type eye development relationship: regulates GO:0031076 ! embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:00Z [Term] id: GO:1902864 name: negative regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie] synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031076 ! embryonic camera-type eye development relationship: negatively_regulates GO:0031076 ! embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:06Z [Term] id: GO:1902865 name: positive regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie] synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031076 ! embryonic camera-type eye development relationship: positively_regulates GO:0031076 ! embryonic camera-type eye development created_by: mr creation_date: 2014-04-03T15:24:12Z [Term] id: GO:1902866 name: regulation of retina development in camera-type eye namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060041 ! retina development in camera-type eye relationship: regulates GO:0060041 ! retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:17Z [Term] id: GO:1902867 name: negative regulation of retina development in camera-type eye namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down regulation of retinal development" RELATED [GOC:TermGenie] synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "downregulation of retinal development" RELATED [GOC:TermGenie] synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "inhibition of retinal development" RELATED [GOC:TermGenie] synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060041 ! retina development in camera-type eye relationship: negatively_regulates GO:0060041 ! retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:23Z [Term] id: GO:1902868 name: positive regulation of retina development in camera-type eye namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "activation of retinal development" RELATED [GOC:TermGenie] synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "upregulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060041 ! retina development in camera-type eye relationship: positively_regulates GO:0060041 ! retina development in camera-type eye created_by: mr creation_date: 2014-04-03T15:24:29Z [Term] id: GO:1902869 name: regulation of amacrine cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0061074 ! regulation of neural retina development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035881 ! amacrine cell differentiation relationship: regulates GO:0035881 ! amacrine cell differentiation created_by: mr creation_date: 2014-04-03T15:24:35Z [Term] id: GO:1902870 name: negative regulation of amacrine cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of amacrine cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of amacrine neuron differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0061076 ! negative regulation of neural retina development is_a: GO:1902869 ! regulation of amacrine cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035881 ! amacrine cell differentiation relationship: negatively_regulates GO:0035881 ! amacrine cell differentiation created_by: mr creation_date: 2014-04-03T15:24:40Z [Term] id: GO:1902871 name: positive regulation of amacrine cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of amacrine cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of amacrine neuron differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0061075 ! positive regulation of neural retina development is_a: GO:1902869 ! regulation of amacrine cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035881 ! amacrine cell differentiation relationship: positively_regulates GO:0035881 ! amacrine cell differentiation created_by: mr creation_date: 2014-04-03T15:24:46Z [Term] id: GO:1902872 name: regulation of horizontal cell localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization is_a: GO:0061074 ! regulation of neural retina development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035852 ! horizontal cell localization relationship: regulates GO:0035852 ! horizontal cell localization created_by: mr creation_date: 2014-04-03T15:24:58Z [Term] id: GO:1902873 name: negative regulation of horizontal cell localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "down regulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "down regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "down regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "down regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "down-regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "down-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "downregulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "downregulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "downregulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "downregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "downregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "inhibition of horizontal cell localisation" NARROW [GOC:TermGenie] synonym: "inhibition of horizontal cell localization" NARROW [GOC:TermGenie] synonym: "inhibition of horizontal cell positioning" NARROW [GOC:TermGenie] synonym: "inhibition of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie] synonym: "inhibition of retinal horizontal cell positioning" NARROW [GOC:TermGenie] synonym: "negative regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "negative regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] is_a: GO:0061076 ! negative regulation of neural retina development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1902872 ! regulation of horizontal cell localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035852 ! horizontal cell localization relationship: negatively_regulates GO:0035852 ! horizontal cell localization created_by: mr creation_date: 2014-04-03T15:25:03Z [Term] id: GO:1902874 name: positive regulation of horizontal cell localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of horizontal cell localisation" NARROW [GOC:TermGenie] synonym: "activation of horizontal cell localization" NARROW [GOC:TermGenie] synonym: "activation of horizontal cell positioning" NARROW [GOC:TermGenie] synonym: "activation of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie] synonym: "activation of retinal horizontal cell positioning" NARROW [GOC:TermGenie] synonym: "positive regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "positive regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "up regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "up regulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "up regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "up regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "up regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "up-regulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "upregulation of horizontal cell localisation" EXACT [GOC:TermGenie] synonym: "upregulation of horizontal cell localization" EXACT [GOC:TermGenie] synonym: "upregulation of horizontal cell positioning" EXACT [GOC:TermGenie] synonym: "upregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] synonym: "upregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] is_a: GO:0061075 ! positive regulation of neural retina development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1902872 ! regulation of horizontal cell localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035852 ! horizontal cell localization relationship: positively_regulates GO:0035852 ! horizontal cell localization created_by: mr creation_date: 2014-04-03T15:25:09Z [Term] id: GO:1902875 name: regulation of embryonic pattern specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie] synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie] synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009880 ! embryonic pattern specification relationship: regulates GO:0009880 ! embryonic pattern specification created_by: mr creation_date: 2014-04-03T15:25:15Z [Term] id: GO:1902876 name: negative regulation of embryonic pattern specification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009880 ! embryonic pattern specification relationship: negatively_regulates GO:0009880 ! embryonic pattern specification created_by: mr creation_date: 2014-04-03T15:25:20Z [Term] id: GO:1902877 name: positive regulation of embryonic pattern specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009880 ! embryonic pattern specification relationship: positively_regulates GO:0009880 ! embryonic pattern specification created_by: mr creation_date: 2014-04-03T15:25:26Z [Term] id: GO:1902878 name: obsolete regulation of BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] is_obsolete: true created_by: mr creation_date: 2014-04-03T15:25:32Z [Term] id: GO:1902879 name: obsolete negative regulation of BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "down regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "down-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "downregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "downregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "downregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "downregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "inhibition of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "inhibition of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "inhibition of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "inhibition of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "negative regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "negative regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "negative regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] is_obsolete: true created_by: mr creation_date: 2014-04-03T15:25:38Z [Term] id: GO:1902880 name: obsolete positive regulation of BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "activation of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "activation of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "activation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "activation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] synonym: "positive regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "positive regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "positive regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "up-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "upregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "upregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "upregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] synonym: "upregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] is_obsolete: true created_by: mr creation_date: 2014-04-03T15:25:43Z [Term] id: GO:1902882 name: regulation of response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006979 ! response to oxidative stress relationship: regulates GO:0006979 ! response to oxidative stress created_by: kmv creation_date: 2014-04-03T20:29:52Z [Term] id: GO:1902883 name: negative regulation of response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006979 ! response to oxidative stress relationship: negatively_regulates GO:0006979 ! response to oxidative stress created_by: kmv creation_date: 2014-04-03T20:30:20Z [Term] id: GO:1902884 name: positive regulation of response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006979 ! response to oxidative stress relationship: positively_regulates GO:0006979 ! response to oxidative stress created_by: kmv creation_date: 2014-04-03T20:30:47Z [Term] id: GO:1902885 name: regulation of proteasome-activating ATPase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] synonym: "regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0061136 ! regulation of proteasomal protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036402 ! proteasome-activating ATPase activity relationship: regulates GO:0036402 ! proteasome-activating ATPase activity created_by: di creation_date: 2014-04-04T17:35:23Z [Term] id: GO:1902886 name: negative regulation of proteasome-activating ATPase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] synonym: "down regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "down regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "down regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "down-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "down-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "downregulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "downregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of proteasomal ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "inhibition of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "inhibition of proteasome-activating ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "negative regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1902885 ! regulation of proteasome-activating ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036402 ! proteasome-activating ATPase activity relationship: negatively_regulates GO:0036402 ! proteasome-activating ATPase activity created_by: di creation_date: 2014-04-04T17:35:30Z [Term] id: GO:1902887 name: positive regulation of proteasome-activating ATPase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] synonym: "activation of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of proteasomal ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "activation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "activation of proteasome-activating ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "positive regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "up regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "up regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "up regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "up-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "up-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome channel gating activity" NARROW [GOC:TermGenie] synonym: "upregulation of proteasome channel opening activity" NARROW [GOC:TermGenie] synonym: "upregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process is_a: GO:1902885 ! regulation of proteasome-activating ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036402 ! proteasome-activating ATPase activity relationship: positively_regulates GO:0036402 ! proteasome-activating ATPase activity created_by: di creation_date: 2014-04-04T17:35:36Z [Term] id: GO:1902888 name: protein localization to astral microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an astral microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030] synonym: "protein localisation in astral microtubule" EXACT [GOC:TermGenie] synonym: "protein localisation to astral microtubule" EXACT [GOC:TermGenie] synonym: "protein localization in astral microtubule" EXACT [GOC:TermGenie] is_a: GO:1902889 ! protein localization to spindle microtubule is_a: GO:1905755 ! protein localization to cytoplasmic microtubule created_by: kmv creation_date: 2014-04-05T21:26:34Z [Term] id: GO:1902889 name: protein localization to spindle microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a spindle microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030] synonym: "protein localisation in spindle microtubule" EXACT [GOC:TermGenie] synonym: "protein localisation to spindle microtubule" EXACT [GOC:TermGenie] synonym: "protein localization in spindle microtubule" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule created_by: kmv creation_date: 2014-04-05T21:31:39Z [Term] id: GO:1902890 name: regulation of root hair elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:1903429 ! regulation of cell maturation is_a: GO:1903888 ! regulation of plant epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048767 ! root hair elongation relationship: regulates GO:0048767 ! root hair elongation created_by: als creation_date: 2014-04-07T13:46:40Z [Term] id: GO:1902891 name: negative regulation of root hair elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] synonym: "down regulation of root hair elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of root hair elongation" EXACT [GOC:TermGenie] synonym: "downregulation of root hair elongation" EXACT [GOC:TermGenie] synonym: "inhibition of root hair elongation" NARROW [GOC:TermGenie] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1902890 ! regulation of root hair elongation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation is_a: GO:1905422 ! negative regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048767 ! root hair elongation relationship: negatively_regulates GO:0048767 ! root hair elongation created_by: als creation_date: 2014-04-07T13:46:47Z [Term] id: GO:1902892 name: positive regulation of root hair elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] synonym: "activation of root hair elongation" NARROW [GOC:TermGenie] synonym: "up regulation of root hair elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of root hair elongation" EXACT [GOC:TermGenie] synonym: "upregulation of root hair elongation" EXACT [GOC:TermGenie] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1902890 ! regulation of root hair elongation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048767 ! root hair elongation relationship: positively_regulates GO:0048767 ! root hair elongation created_by: als creation_date: 2014-04-07T13:46:53Z [Term] id: GO:1902893 name: regulation of pri-miRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] synonym: "regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II relationship: regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II created_by: dph creation_date: 2014-04-08T13:22:08Z [Term] id: GO:1902894 name: negative regulation of pri-miRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] synonym: "down regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "downregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "inhibition of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1902893 ! regulation of pri-miRNA transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II relationship: negatively_regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II created_by: dph creation_date: 2014-04-08T13:22:14Z [Term] id: GO:1902895 name: positive regulation of pri-miRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] synonym: "activation of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1902893 ! regulation of pri-miRNA transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II relationship: positively_regulates GO:0061614 ! pri-miRNA transcription by RNA polymerase II created_by: dph creation_date: 2014-04-08T13:22:20Z [Term] id: GO:1902896 name: terminal web assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a terminal web." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:21949650] synonym: "terminal web formation" EXACT [GOC:TermGenie] is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0070925 ! organelle assembly created_by: kmv creation_date: 2014-04-08T15:15:25Z [Term] id: GO:1902897 name: regulation of postsynaptic density protein 95 clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:10570482] synonym: "regulation of Dlg4 clustering" EXACT [GOC:TermGenie] synonym: "regulation of post-synaptic density protein 95 clustering" EXACT [GOC:TermGenie] synonym: "regulation of PSD-95 clustering" EXACT [GOC:TermGenie] is_a: GO:1901626 ! regulation of postsynaptic membrane organization is_a: GO:1905475 ! regulation of protein localization to membrane is_a: GO:1905874 ! regulation of postsynaptic density organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097119 ! postsynaptic density protein 95 clustering relationship: regulates GO:0097119 ! postsynaptic density protein 95 clustering created_by: als creation_date: 2014-04-09T14:52:08Z [Term] id: GO:1902898 name: fatty acid methyl ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218] synonym: "FAME metabolic process" EXACT [] synonym: "fatty acid methyl ester metabolism" EXACT [GOC:TermGenie] is_a: GO:0006629 ! lipid metabolic process created_by: tt creation_date: 2014-04-11T03:08:34Z [Term] id: GO:1902899 name: fatty acid methyl ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218] synonym: "FAME biosynthetic process" EXACT [] synonym: "fatty acid methyl ester anabolism" EXACT [GOC:TermGenie] synonym: "fatty acid methyl ester biosynthesis" EXACT [GOC:TermGenie] synonym: "fatty acid methyl ester formation" EXACT [GOC:TermGenie] synonym: "fatty acid methyl ester synthesis" EXACT [GOC:TermGenie] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1902898 ! fatty acid methyl ester metabolic process created_by: tt creation_date: 2014-04-11T03:08:40Z [Term] id: GO:1902900 name: gut granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a gut granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:17202409] synonym: "gut granule biogenesis" EXACT [pmid:17202409] synonym: "gut granule formation" EXACT [GOC:TermGenie] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly created_by: kmv creation_date: 2014-04-14T14:28:17Z [Term] id: GO:1902901 name: positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:17888400] synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" NARROW [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:1990170 ! stress response to cadmium ion relationship: part_of GO:1990170 ! stress response to cadmium ion created_by: kmv creation_date: 2014-04-14T18:03:42Z [Term] id: GO:1902902 name: negative regulation of autophagosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012] synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie] synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie] synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie] synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie] synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie] synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:2000785 ! regulation of autophagosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000045 ! autophagosome assembly relationship: negatively_regulates GO:0000045 ! autophagosome assembly created_by: als creation_date: 2014-04-15T10:37:40Z [Term] id: GO:1902903 name: regulation of supramolecular fiber organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097435 ! supramolecular fiber organization relationship: regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:36Z [Term] id: GO:1902904 name: negative regulation of supramolecular fiber organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097435 ! supramolecular fiber organization relationship: negatively_regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:42Z [Term] id: GO:1902905 name: positive regulation of supramolecular fiber organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of fibril organization" NARROW [GOC:TermGenie] synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097435 ! supramolecular fiber organization relationship: positively_regulates GO:0097435 ! supramolecular fiber organization created_by: rl creation_date: 2014-04-15T16:46:48Z [Term] id: GO:1902906 name: proteasome storage granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178] synonym: "proteasome storage granule formation" EXACT [GOC:TermGenie] synonym: "PSG assembly" EXACT [GOC:TermGenie] synonym: "PSG formation" EXACT [GOC:TermGenie] is_a: GO:0043248 ! proteasome assembly created_by: di creation_date: 2014-04-16T01:59:41Z [Term] id: GO:1902907 name: proteasome storage granule disassembly namespace: biological_process def: "The disaggregation of a proteasome storage granule into its constituent components." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178] synonym: "PSG disassembly" EXACT [GOC:TermGenie] is_a: GO:1903009 ! proteasome complex disassembly created_by: di creation_date: 2014-04-16T01:59:47Z [Term] id: GO:1902908 name: regulation of melanosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032402 ! melanosome transport relationship: regulates GO:0032402 ! melanosome transport created_by: als creation_date: 2014-04-17T11:40:16Z [Term] id: GO:1902909 name: negative regulation of melanosome transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] synonym: "down regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "inhibition of melanosome transport" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport is_a: GO:1902908 ! regulation of melanosome transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032402 ! melanosome transport relationship: negatively_regulates GO:0032402 ! melanosome transport created_by: als creation_date: 2014-04-17T11:40:28Z [Term] id: GO:1902910 name: positive regulation of melanosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] synonym: "activation of melanosome transport" NARROW [GOC:TermGenie] synonym: "up regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome transport" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome transport" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport is_a: GO:1902908 ! regulation of melanosome transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032402 ! melanosome transport relationship: positively_regulates GO:0032402 ! melanosome transport created_by: als creation_date: 2014-04-17T11:40:34Z [Term] id: GO:1902911 name: protein kinase complex namespace: cellular_component def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: bhm creation_date: 2014-04-17T13:52:40Z [Term] id: GO:1902912 name: pyruvate kinase complex namespace: cellular_component def: "A protein complex which is capable of pyruvate kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups created_by: bhm creation_date: 2014-04-17T14:11:41Z [Term] id: GO:1902913 name: positive regulation of neuroepithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506] synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060563 ! neuroepithelial cell differentiation relationship: positively_regulates GO:0060563 ! neuroepithelial cell differentiation created_by: mr creation_date: 2014-04-18T21:06:42Z [Term] id: GO:1902914 name: regulation of protein polyubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] synonym: "regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031396 ! regulation of protein ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000209 ! protein polyubiquitination relationship: regulates GO:0000209 ! protein polyubiquitination created_by: di creation_date: 2014-04-18T22:09:52Z [Term] id: GO:1902915 name: negative regulation of protein polyubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] synonym: "down regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "down regulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "down-regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "down-regulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "downregulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "downregulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "inhibition of polyubiquitin" RELATED [GOC:TermGenie] synonym: "inhibition of protein polyubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of protein polyubiquitinylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein polyubiquitylation" NARROW [GOC:TermGenie] synonym: "negative regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "negative regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:1902914 ! regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000209 ! protein polyubiquitination relationship: negatively_regulates GO:0000209 ! protein polyubiquitination created_by: di creation_date: 2014-04-18T22:09:58Z [Term] id: GO:1902916 name: positive regulation of protein polyubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] synonym: "activation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "activation of protein polyubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein polyubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of protein polyubiquitylation" NARROW [GOC:TermGenie] synonym: "positive regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "positive regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "up regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "up regulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "up-regulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "up-regulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] synonym: "upregulation of polyubiquitin" RELATED [GOC:TermGenie] synonym: "upregulation of protein polyubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein polyubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031398 ! positive regulation of protein ubiquitination is_a: GO:1902914 ! regulation of protein polyubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000209 ! protein polyubiquitination relationship: positively_regulates GO:0000209 ! protein polyubiquitination created_by: di creation_date: 2014-04-18T22:10:04Z [Term] id: GO:1902917 name: positive regulation of mating projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mating projection assembly." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:12455985] synonym: "activation of mating projection assembly" NARROW [GOC:TermGenie] synonym: "activation of mating projection biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of mating projection biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of mating projection assembly" EXACT [GOC:TermGenie] synonym: "up regulation of mating projection biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of mating projection assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of mating projection biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of mating projection assembly" EXACT [GOC:TermGenie] synonym: "upregulation of mating projection biogenesis" RELATED [GOC:TermGenie] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0031383 ! regulation of mating projection assembly is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031382 ! mating projection formation relationship: positively_regulates GO:0031382 ! mating projection formation created_by: di creation_date: 2014-04-20T11:18:03Z [Term] id: GO:1902918 name: poly(5-hydroxyvalerate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(5-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process created_by: tt creation_date: 2014-04-21T18:47:06Z [Term] id: GO:1902919 name: poly(5-hydroxyvalerate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(5-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] synonym: "poly(5-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(5-hydroxyvalerate) formation" EXACT [GOC:TermGenie] synonym: "poly(5-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] is_a: GO:1902918 ! poly(5-hydroxyvalerate) metabolic process is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process created_by: tt creation_date: 2014-04-21T18:47:12Z [Term] id: GO:1902920 name: poly(hydroxyvalerate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process created_by: tt creation_date: 2014-04-21T19:12:32Z [Term] id: GO:1902921 name: poly(hydroxyvalerate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] synonym: "poly(hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(hydroxyvalerate) formation" EXACT [GOC:TermGenie] synonym: "poly(hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process created_by: tt creation_date: 2014-04-21T19:12:38Z [Term] id: GO:1902922 name: poly(3-hydroxyvalerate) metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(3-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process created_by: tt creation_date: 2014-04-21T19:13:56Z [Term] id: GO:1902923 name: poly(3-hydroxyvalerate) biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] synonym: "poly(3-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] synonym: "poly(3-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] synonym: "poly(3-hydroxyvalerate) formation" EXACT [GOC:TermGenie] synonym: "poly(3-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process is_a: GO:1902922 ! poly(3-hydroxyvalerate) metabolic process created_by: tt creation_date: 2014-04-21T19:14:02Z [Term] id: GO:1902924 name: poly(hydroxyalkanoate) biosynthetic process from glucose namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:24425304] synonym: "poly(hydroxyalkanoate) anabolism from glucose" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) biosynthesis from glucose" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) formation from glucose" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) synthesis from glucose" EXACT [GOC:TermGenie] is_a: GO:0006006 ! glucose metabolic process is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process created_by: tt creation_date: 2014-04-21T22:49:07Z [Term] id: GO:1902925 name: poly(hydroxyalkanoate) biosynthetic process from fatty acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:21129764] synonym: "poly(hydroxyalkanoate) anabolism from fatty acid" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) biosynthesis from fatty acid" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) formation from fatty acid" EXACT [GOC:TermGenie] synonym: "poly(hydroxyalkanoate) synthesis from fatty acid" EXACT [GOC:TermGenie] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process created_by: tt creation_date: 2014-04-21T22:53:59Z [Term] id: GO:1902926 name: inulin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. synonym: "inulin metabolism" EXACT [GOC:TermGenie] is_a: GO:0010145 ! fructan metabolic process created_by: se creation_date: 2014-04-21T23:54:33Z [Term] id: GO:1902927 name: inulin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. synonym: "inulin breakdown" EXACT [GOC:TermGenie] synonym: "inulin catabolism" EXACT [GOC:TermGenie] synonym: "inulin degradation" EXACT [GOC:TermGenie] is_a: GO:0010147 ! fructan catabolic process is_a: GO:1902926 ! inulin metabolic process created_by: se creation_date: 2014-04-21T23:54:45Z [Term] id: GO:1902928 name: inulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. synonym: "inulin anabolism" EXACT [GOC:TermGenie] synonym: "inulin biosynthesis" EXACT [GOC:TermGenie] synonym: "inulin formation" EXACT [GOC:TermGenie] synonym: "inulin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010146 ! fructan biosynthetic process is_a: GO:1902926 ! inulin metabolic process created_by: se creation_date: 2014-04-21T23:54:51Z [Term] id: GO:1902929 name: plasma membrane of growing cell tip namespace: cellular_component def: "Any plasma membrane part that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:17085965] synonym: "growing cell tip plasma membrane part" EXACT [GOC:TermGenie] synonym: "plasma membrane part of growing cell end" EXACT [GOC:TermGenie] synonym: "plasma membrane part of growing cell tip" EXACT [GOC:TermGenie] is_a: GO:0031520 ! plasma membrane of cell tip intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0035838 ! growing cell tip relationship: part_of GO:0035838 ! growing cell tip created_by: mah creation_date: 2014-04-22T16:02:06Z [Term] id: GO:1902930 name: regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "regulation of solventogenesis" BROAD [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046165 ! alcohol biosynthetic process relationship: regulates GO:0046165 ! alcohol biosynthetic process created_by: tt creation_date: 2014-04-22T21:55:03Z [Term] id: GO:1902931 name: negative regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "down regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "down regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "down-regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "downregulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of alcohol anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol formation" NARROW [GOC:TermGenie] synonym: "inhibition of alcohol synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "negative regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of solventogenesis" BROAD [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046165 ! alcohol biosynthetic process relationship: negatively_regulates GO:0046165 ! alcohol biosynthetic process created_by: tt creation_date: 2014-04-22T21:55:13Z [Term] id: GO:1902932 name: positive regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "activation of alcohol anabolism" NARROW [GOC:TermGenie] synonym: "activation of alcohol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of alcohol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of alcohol formation" NARROW [GOC:TermGenie] synonym: "activation of alcohol synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of solventogenesis" BROAD [] synonym: "up regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "up regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "upregulation of alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046165 ! alcohol biosynthetic process relationship: positively_regulates GO:0046165 ! alcohol biosynthetic process created_by: tt creation_date: 2014-04-22T21:55:19Z [Term] id: GO:1902933 name: isopentenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564] synonym: "isopentenol metabolism" EXACT [GOC:TermGenie] is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: tt creation_date: 2014-04-24T16:51:35Z [Term] id: GO:1902934 name: isopentenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564] synonym: "isopentenol anabolism" EXACT [GOC:TermGenie] synonym: "isopentenol biosynthesis" EXACT [GOC:TermGenie] synonym: "isopentenol formation" EXACT [GOC:TermGenie] synonym: "isopentenol synthesis" EXACT [GOC:TermGenie] is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1902933 ! isopentenol metabolic process created_by: tt creation_date: 2014-04-24T16:51:42Z [Term] id: GO:1902935 name: protein localization to septin ring namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a septin ring." [GO_REF:0000087, GOC:TermGenie, PMID:16325501] synonym: "protein localisation in septin ring" EXACT [GOC:TermGenie] synonym: "protein localisation to septin ring" EXACT [GOC:TermGenie] synonym: "protein localization in septin ring" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton is_a: GO:0072697 ! protein localization to cell cortex created_by: mah creation_date: 2014-04-25T13:08:17Z [Term] id: GO:1902936 name: phosphatidylinositol bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034] comment: An example of this is KCNJ2 in human (P63252) in PMID:18690034 (inferred from direct assay) is_a: GO:1901981 ! phosphatidylinositol phosphate binding created_by: bhm creation_date: 2014-04-25T15:14:12Z [Term] id: GO:1902937 name: inward rectifier potassium channel complex namespace: cellular_component def: "A protein complex which is capable of inward rectifier potassium channel activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16834334] comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). is_a: GO:0008076 ! voltage-gated potassium channel complex created_by: bhm creation_date: 2014-04-25T15:18:41Z [Term] id: GO:1902938 name: regulation of intracellular calcium activated chloride channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport is_a: GO:2001225 ! regulation of chloride transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005229 ! intracellular calcium activated chloride channel activity relationship: regulates GO:0005229 ! intracellular calcium activated chloride channel activity created_by: als creation_date: 2014-04-28T08:49:08Z [Term] id: GO:1902939 name: negative regulation of intracellular calcium activated chloride channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] synonym: "down regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport is_a: GO:2001226 ! negative regulation of chloride transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity relationship: negatively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity created_by: als creation_date: 2014-04-28T08:49:14Z [Term] id: GO:1902940 name: positive regulation of intracellular calcium activated chloride channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] synonym: "activation of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] is_a: GO:1901529 ! positive regulation of anion channel activity is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity relationship: positively_regulates GO:0005229 ! intracellular calcium activated chloride channel activity created_by: als creation_date: 2014-04-28T08:49:20Z [Term] id: GO:1902941 name: regulation of voltage-gated chloride channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] synonym: "regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport is_a: GO:2001225 ! regulation of chloride transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005247 ! voltage-gated chloride channel activity relationship: regulates GO:0005247 ! voltage-gated chloride channel activity created_by: als creation_date: 2014-04-28T08:55:31Z [Term] id: GO:1902942 name: negative regulation of voltage-gated chloride channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] synonym: "down regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of voltage gated chloride channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated chloride channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport is_a: GO:2001226 ! negative regulation of chloride transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005247 ! voltage-gated chloride channel activity relationship: negatively_regulates GO:0005247 ! voltage-gated chloride channel activity created_by: als creation_date: 2014-04-28T08:55:37Z [Term] id: GO:1902943 name: positive regulation of voltage-gated chloride channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] synonym: "activation of voltage gated chloride channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated chloride channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] is_a: GO:1901529 ! positive regulation of anion channel activity is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005247 ! voltage-gated chloride channel activity relationship: positively_regulates GO:0005247 ! voltage-gated chloride channel activity created_by: als creation_date: 2014-04-28T08:55:43Z [Term] id: GO:1902944 name: aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process namespace: molecular_function def: "Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:10206644, PMID:24577224] synonym: "aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] is_a: GO:0004190 ! aspartic-type endopeptidase activity intersection_of: GO:0004190 ! aspartic-type endopeptidase activity intersection_of: part_of GO:0042987 ! amyloid precursor protein catabolic process relationship: part_of GO:0042987 ! amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-02T07:59:42Z [Term] id: GO:1902945 name: metalloendopeptidase activity involved in amyloid precursor protein catabolic process namespace: molecular_function def: "Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360] synonym: "metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] xref: Reactome:R-HSA-9010034 "ADAM10:Zn2+:TSPANs cleaves APP(18-770)" is_a: GO:0004222 ! metalloendopeptidase activity intersection_of: GO:0004222 ! metalloendopeptidase activity intersection_of: part_of GO:0042987 ! amyloid precursor protein catabolic process relationship: part_of GO:0042987 ! amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-02T08:13:04Z [Term] id: GO:1902946 name: protein localization to early endosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an early endosome." [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900] synonym: "protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "protein localization in early endosome" EXACT [GOC:TermGenie] is_a: GO:0036010 ! protein localization to endosome created_by: sjp creation_date: 2014-05-02T08:26:00Z [Term] id: GO:1902947 name: regulation of tau-protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] synonym: "regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:tau-protein O-phosphotransferase activity" BROAD [GOC:TermGenie] synonym: "regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "regulation of GSK" RELATED [GOC:TermGenie] synonym: "regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of STK31" RELATED [GOC:TermGenie] synonym: "regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of TPK" RELATED [GOC:TermGenie] synonym: "regulation of TPK I" RELATED [GOC:TermGenie] synonym: "regulation of TPK II" RELATED [GOC:TermGenie] synonym: "regulation of TTK" RELATED [GOC:TermGenie] is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050321 ! tau-protein kinase activity relationship: regulates GO:0050321 ! tau-protein kinase activity created_by: sjp creation_date: 2014-05-02T08:43:27Z [Term] id: GO:1902948 name: negative regulation of tau-protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] synonym: "down regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "down regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "down regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "down regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "down regulation of GSK" RELATED [GOC:TermGenie] synonym: "down regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of STK31" RELATED [GOC:TermGenie] synonym: "down regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "down regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "down regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of TPK" RELATED [GOC:TermGenie] synonym: "down regulation of TPK I" RELATED [GOC:TermGenie] synonym: "down regulation of TPK II" RELATED [GOC:TermGenie] synonym: "down regulation of TTK" RELATED [GOC:TermGenie] synonym: "down-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "down-regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "down-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "down-regulation of GSK" RELATED [GOC:TermGenie] synonym: "down-regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of STK31" RELATED [GOC:TermGenie] synonym: "down-regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "down-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "down-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of TPK" RELATED [GOC:TermGenie] synonym: "down-regulation of TPK I" RELATED [GOC:TermGenie] synonym: "down-regulation of TPK II" RELATED [GOC:TermGenie] synonym: "down-regulation of TTK" RELATED [GOC:TermGenie] synonym: "downregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "downregulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "downregulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "downregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "downregulation of GSK" RELATED [GOC:TermGenie] synonym: "downregulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of STK31" RELATED [GOC:TermGenie] synonym: "downregulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "downregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "downregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of TPK" RELATED [GOC:TermGenie] synonym: "downregulation of TPK I" RELATED [GOC:TermGenie] synonym: "downregulation of TPK II" RELATED [GOC:TermGenie] synonym: "downregulation of TTK" RELATED [GOC:TermGenie] synonym: "inhibition of [Tau protein] kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "inhibition of cdk5/p20" RELATED [GOC:TermGenie] synonym: "inhibition of CDK5/p23" RELATED [GOC:TermGenie] synonym: "inhibition of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie] synonym: "inhibition of GSK" RELATED [GOC:TermGenie] synonym: "inhibition of protein tau kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of STK31" RELATED [GOC:TermGenie] synonym: "inhibition of tau kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tau protein kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tau-protein kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "inhibition of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "inhibition of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of TPK" RELATED [GOC:TermGenie] synonym: "inhibition of TPK I" RELATED [GOC:TermGenie] synonym: "inhibition of TPK II" RELATED [GOC:TermGenie] synonym: "inhibition of TTK" RELATED [GOC:TermGenie] synonym: "negative regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "negative regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "negative regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "negative regulation of GSK" RELATED [GOC:TermGenie] synonym: "negative regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of STK31" RELATED [GOC:TermGenie] synonym: "negative regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "negative regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "negative regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of TPK" RELATED [GOC:TermGenie] synonym: "negative regulation of TPK I" RELATED [GOC:TermGenie] synonym: "negative regulation of TPK II" RELATED [GOC:TermGenie] synonym: "negative regulation of TTK" RELATED [GOC:TermGenie] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:1902947 ! regulation of tau-protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050321 ! tau-protein kinase activity relationship: negatively_regulates GO:0050321 ! tau-protein kinase activity created_by: sjp creation_date: 2014-05-02T08:43:32Z [Term] id: GO:1902949 name: positive regulation of tau-protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] synonym: "activation of [Tau protein] kinase activity" NARROW [GOC:TermGenie] synonym: "activation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "activation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "activation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "activation of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie] synonym: "activation of GSK" RELATED [GOC:TermGenie] synonym: "activation of protein tau kinase activity" NARROW [GOC:TermGenie] synonym: "activation of STK31" RELATED [GOC:TermGenie] synonym: "activation of tau kinase activity" NARROW [GOC:TermGenie] synonym: "activation of tau protein kinase activity" NARROW [GOC:TermGenie] synonym: "activation of tau-protein kinase activity" NARROW [GOC:TermGenie] synonym: "activation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "activation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "activation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "activation of TPK" RELATED [GOC:TermGenie] synonym: "activation of TPK I" RELATED [GOC:TermGenie] synonym: "activation of TPK II" RELATED [GOC:TermGenie] synonym: "activation of TTK" RELATED [GOC:TermGenie] synonym: "positive regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "positive regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "positive regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "positive regulation of GSK" RELATED [GOC:TermGenie] synonym: "positive regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of STK31" RELATED [GOC:TermGenie] synonym: "positive regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "positive regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "positive regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of TPK" RELATED [GOC:TermGenie] synonym: "positive regulation of TPK I" RELATED [GOC:TermGenie] synonym: "positive regulation of TPK II" RELATED [GOC:TermGenie] synonym: "positive regulation of TTK" RELATED [GOC:TermGenie] synonym: "up regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "up regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "up regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "up regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "up regulation of GSK" RELATED [GOC:TermGenie] synonym: "up regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of STK31" RELATED [GOC:TermGenie] synonym: "up regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "up regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "up regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of TPK" RELATED [GOC:TermGenie] synonym: "up regulation of TPK I" RELATED [GOC:TermGenie] synonym: "up regulation of TPK II" RELATED [GOC:TermGenie] synonym: "up regulation of TTK" RELATED [GOC:TermGenie] synonym: "up-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "up-regulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "up-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "up-regulation of GSK" RELATED [GOC:TermGenie] synonym: "up-regulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of STK31" RELATED [GOC:TermGenie] synonym: "up-regulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "up-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "up-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of TPK" RELATED [GOC:TermGenie] synonym: "up-regulation of TPK I" RELATED [GOC:TermGenie] synonym: "up-regulation of TPK II" RELATED [GOC:TermGenie] synonym: "up-regulation of TTK" RELATED [GOC:TermGenie] synonym: "upregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] synonym: "upregulation of cdk5/p20" RELATED [GOC:TermGenie] synonym: "upregulation of CDK5/p23" RELATED [GOC:TermGenie] synonym: "upregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] synonym: "upregulation of GSK" RELATED [GOC:TermGenie] synonym: "upregulation of protein tau kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of STK31" RELATED [GOC:TermGenie] synonym: "upregulation of tau kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tau protein kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tau-protein kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] synonym: "upregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] synonym: "upregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of TPK" RELATED [GOC:TermGenie] synonym: "upregulation of TPK I" RELATED [GOC:TermGenie] synonym: "upregulation of TPK II" RELATED [GOC:TermGenie] synonym: "upregulation of TTK" RELATED [GOC:TermGenie] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:1902947 ! regulation of tau-protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050321 ! tau-protein kinase activity relationship: positively_regulates GO:0050321 ! tau-protein kinase activity created_by: sjp creation_date: 2014-05-02T08:43:38Z [Term] id: GO:1902950 name: regulation of dendritic spine maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] is_a: GO:0099175 ! regulation of postsynapse organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097062 ! dendritic spine maintenance relationship: regulates GO:0097062 ! dendritic spine maintenance created_by: sjp creation_date: 2014-05-02T08:48:47Z [Term] id: GO:1902951 name: negative regulation of dendritic spine maintenance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] synonym: "down regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of dendritic spine maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of dendritic spine maintenance" NARROW [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:1902950 ! regulation of dendritic spine maintenance is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097062 ! dendritic spine maintenance relationship: negatively_regulates GO:0097062 ! dendritic spine maintenance created_by: sjp creation_date: 2014-05-02T08:48:53Z [Term] id: GO:1902952 name: positive regulation of dendritic spine maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] synonym: "activation of dendritic spine maintenance" NARROW [GOC:TermGenie] synonym: "up regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of dendritic spine maintenance" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:1902950 ! regulation of dendritic spine maintenance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097062 ! dendritic spine maintenance relationship: positively_regulates GO:0097062 ! dendritic spine maintenance created_by: sjp creation_date: 2014-05-02T08:48:59Z [Term] id: GO:1902953 name: positive regulation of ER to Golgi vesicle-mediated transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:17855360] synonym: "activation of endoplasmic reticulum to Golgi transport" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] synonym: "activation of ER to Golgi transport" NARROW [GOC:TermGenie] synonym: "activation of ER to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] synonym: "activation of rough endoplasmic reticulum to cis-Golgi transport" NARROW [GOC:TermGenie] synonym: "activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] synonym: "activation of rough ER to cis-Golgi transport" NARROW [GOC:TermGenie] synonym: "activation of rough ER to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "positive regulation of ER to Golgi transport" EXACT [GOC:TermGenie] synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "positive regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "positive regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up regulation of ER to Golgi transport" EXACT [GOC:TermGenie] synonym: "up regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "up regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up-regulation of ER to Golgi transport" EXACT [GOC:TermGenie] synonym: "up-regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "up-regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "up-regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "upregulation of ER to Golgi transport" EXACT [GOC:TermGenie] synonym: "upregulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] synonym: "upregulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] synonym: "upregulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport relationship: positively_regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: sjp creation_date: 2014-05-02T08:59:18Z [Term] id: GO:1902954 name: regulation of early endosome to recycling endosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061502 ! early endosome to recycling endosome transport relationship: regulates GO:0061502 ! early endosome to recycling endosome transport created_by: sjp creation_date: 2014-05-02T09:06:23Z [Term] id: GO:1902955 name: positive regulation of early endosome to recycling endosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] synonym: "activation of early endosome to recycling endosome transport" NARROW [GOC:TermGenie] synonym: "up regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] synonym: "up-regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] synonym: "upregulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] is_a: GO:1902954 ! regulation of early endosome to recycling endosome transport is_a: GO:1903651 ! positive regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061502 ! early endosome to recycling endosome transport relationship: positively_regulates GO:0061502 ! early endosome to recycling endosome transport created_by: sjp creation_date: 2014-05-02T09:06:29Z [Term] id: GO:1902956 name: regulation of mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] synonym: "regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone relationship: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone created_by: dph creation_date: 2014-05-02T15:30:12Z [Term] id: GO:1902957 name: negative regulation of mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] synonym: "down regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "down regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "down regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "down-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "down-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "downregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "downregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "downregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "inhibition of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "inhibition of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie] synonym: "inhibition of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie] synonym: "negative regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "negative regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone is_a: GO:1905447 ! negative regulation of mitochondrial ATP synthesis coupled electron transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone relationship: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone created_by: dph creation_date: 2014-05-02T15:30:18Z [Term] id: GO:1902958 name: positive regulation of mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] synonym: "activation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "activation of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie] synonym: "activation of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie] synonym: "positive regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "positive regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "up regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "up regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "up regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "up-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "up-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "upregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] synonym: "upregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] synonym: "upregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone is_a: GO:1905448 ! positive regulation of mitochondrial ATP synthesis coupled electron transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone relationship: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone created_by: dph creation_date: 2014-05-02T15:30:24Z [Term] id: GO:1902959 name: regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] synonym: "regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0052548 ! regulation of endopeptidase activity is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process is_a: GO:1905245 ! regulation of aspartic-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process relationship: regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:07:04Z [Term] id: GO:1902960 name: negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process is_a: GO:1905246 ! negative regulation of aspartic-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process relationship: negatively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:07:11Z [Term] id: GO:1902961 name: positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] synonym: "activation of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0010950 ! positive regulation of endopeptidase activity is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process is_a: GO:1905247 ! positive regulation of aspartic-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process relationship: positively_regulates GO:1902944 ! aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:07:17Z [Term] id: GO:1902962 name: regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process is_a: GO:1904683 ! regulation of metalloendopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process relationship: regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:11:55Z [Term] id: GO:1902963 name: negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process is_a: GO:1904684 ! negative regulation of metalloendopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process relationship: negatively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:12:01Z [Term] id: GO:1902964 name: positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process is_a: GO:1904685 ! positive regulation of metalloendopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process relationship: positively_regulates GO:1902945 ! metalloendopeptidase activity involved in amyloid precursor protein catabolic process created_by: sjp creation_date: 2014-05-06T09:12:11Z [Term] id: GO:1902965 name: regulation of protein localization to early endosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] synonym: "regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in early endosome" EXACT [GOC:TermGenie] is_a: GO:1905666 ! regulation of protein localization to endosome intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902946 ! protein localization to early endosome relationship: regulates GO:1902946 ! protein localization to early endosome created_by: sjp creation_date: 2014-05-06T09:28:24Z [Term] id: GO:1902966 name: positive regulation of protein localization to early endosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] synonym: "activation of protein localisation in early endosome" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to early endosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization in early endosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization to early endosome" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in early endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in early endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to early endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in early endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to early endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in early endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to early endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in early endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to early endosome" EXACT [GOC:TermGenie] is_a: GO:1902965 ! regulation of protein localization to early endosome is_a: GO:1905668 ! positive regulation of protein localization to endosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902946 ! protein localization to early endosome relationship: positively_regulates GO:1902946 ! protein localization to early endosome created_by: sjp creation_date: 2014-05-06T09:28:30Z [Term] id: GO:1902967 name: protein localization to mitotic spindle midzone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone." [GO_REF:0000087, GOC:TermGenie, PMID:16824200] synonym: "protein localisation in mitotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle midzone" EXACT [GOC:TermGenie] is_a: GO:1902480 ! protein localization to mitotic spindle created_by: mah creation_date: 2014-05-06T14:40:01Z [Term] id: GO:1902969 name: mitotic DNA replication namespace: biological_process def: "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "mitotic cell cycle DNA replication" EXACT [] synonym: "mitotic nuclear cell cycle DNA replication" EXACT [] synonym: "nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [] is_a: GO:0033260 ! nuclear DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0033260 ! nuclear DNA replication intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-06T15:03:03Z [Term] id: GO:1902970 name: premeiotic DNA replication DNA duplex unwinding namespace: biological_process def: "Any DNA duplex unwinding involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA duplex unwinding involved in meiotic cell cycle DNA replication" EXACT [] synonym: "DNA duplex unwinding involved in meiotic DNA replication" EXACT [] is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding intersection_of: GO:1902320 ! nuclear DNA replication DNA duplex unwinding intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T15:20:41Z [Term] id: GO:1902971 name: mitotic DNA replication DNA duplex unwinding namespace: biological_process def: "Any DNA duplex unwinding involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA duplex unwinding involved in mitotic cell cycle DNA replication" EXACT [] synonym: "DNA duplex unwinding involved in mitotic DNA replication" EXACT [] is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902320 ! nuclear DNA replication DNA duplex unwinding intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T15:20:47Z [Term] id: GO:1902972 name: premeiotic DNA replication DNA ligation namespace: biological_process def: "Any DNA ligation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA ligation involved in meiotic cell cycle DNA replication" RELATED [] synonym: "DNA ligation involved in meiotic DNA replication" EXACT [] is_a: GO:1902333 ! nuclear DNA replication DNA ligation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902333 ! nuclear DNA replication DNA ligation intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T15:20:53Z [Term] id: GO:1902973 name: mitotic DNA replication DNA ligation namespace: biological_process def: "Any DNA ligation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA ligation involved in mitotic cell cycle DNA replication" EXACT [] synonym: "DNA ligation involved in mitotic DNA replication" EXACT [] is_a: GO:1902333 ! nuclear DNA replication DNA ligation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902333 ! nuclear DNA replication DNA ligation intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T15:20:59Z [Term] id: GO:1902974 name: meiotic DNA replication initiation namespace: biological_process def: "Any DNA replication initiation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication initiation involved in meiotic cell cycle DNA replication" EXACT [] synonym: "DNA replication initiation involved in meiotic DNA replication" EXACT [] is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-06T15:21:06Z [Term] id: GO:1902975 name: mitotic DNA replication initiation namespace: biological_process def: "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T15:21:11Z [Term] id: GO:1902976 name: premeiotic DNA replication preinitiation complex assembly namespace: biological_process def: "Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication preinitiation complex formation involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "pre-IC complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0071163 ! DNA replication preinitiation complex assembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0071163 ! DNA replication preinitiation complex assembly intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T19:19:31Z [Term] id: GO:1902977 name: mitotic DNA replication preinitiation complex assembly namespace: biological_process def: "Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication preinitiation complex formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "pre-IC complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0071163 ! DNA replication preinitiation complex assembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0071163 ! DNA replication preinitiation complex assembly intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T19:19:37Z [Term] id: GO:1902978 name: premeiotic DNA replication termination namespace: biological_process def: "Any DNA replication termination involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication termination involved in meiotic cell cycle DNA replication" EXACT [] synonym: "DNA replication termination involved in meiotic DNA replication" EXACT [] is_a: GO:1902317 ! nuclear DNA replication termination is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902317 ! nuclear DNA replication termination intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T19:19:43Z [Term] id: GO:1902979 name: mitotic DNA replication termination namespace: biological_process def: "Any DNA replication termination involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication termination involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902317 ! nuclear DNA replication termination is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902317 ! nuclear DNA replication termination intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T19:19:49Z [Term] id: GO:1902980 name: synthesis of RNA primer involved in premeiotic DNA replication namespace: biological_process def: "Any synthesis of RNA primer involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "synthesis of RNA primer involved in meiotic cell cycle DNA replication" EXACT [] is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T19:19:54Z [Term] id: GO:1902981 name: synthesis of RNA primer involved in mitotic DNA replication namespace: biological_process alt_id: GO:1903458 def: "Any synthesis of RNA primer involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "synthesis of RNA primer involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006269 ! DNA replication, synthesis of RNA primer intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T19:20:00Z [Term] id: GO:1902982 name: DNA strand elongation involved in premeiotic DNA replication namespace: biological_process def: "Any DNA strand elongation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA strand elongation involved in meiotic cell cycle DNA replication" EXACT [] is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T20:33:15Z [Term] id: GO:1902983 name: DNA strand elongation involved in mitotic DNA replication namespace: biological_process def: "Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA strand elongation involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T20:33:22Z [Term] id: GO:1902984 name: pre-replicative complex assembly involved in premeiotic DNA replication namespace: biological_process def: "Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "nuclear pre-replicative complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "pre-RC complex assembly involved in meiosis" BROAD [GOC:TermGenie] synonym: "pre-replicative complex assembly involved in meiosis" BROAD [GOC:TermGenie] synonym: "pre-replicative complex assembly involved in meiotic cell cycle DNA replication" EXACT [] synonym: "pre-replicative complex formation involved in meiosis" BROAD [GOC:TermGenie] is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication created_by: jl creation_date: 2014-05-06T20:33:28Z [Term] id: GO:1902985 name: mitotic pre-replicative complex assembly namespace: biological_process def: "Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "nuclear pre-replicative complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "pre-replicative complex assembly involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: jl creation_date: 2014-05-06T20:33:34Z [Term] id: GO:1902986 name: regulation of lysine biosynthetic process via aminoadipic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464] synonym: "regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid relationship: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid created_by: al creation_date: 2014-05-07T08:07:08Z [Term] id: GO:1902987 name: negative regulation of lysine biosynthetic process via aminoadipic acid namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464] synonym: "down regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "down regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "down regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "down regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "down regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "downregulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "downregulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "downregulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "downregulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "downregulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "downregulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "downregulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "downregulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "inhibition of lysine anabolism via aminoadipic acid" NARROW [GOC:TermGenie] synonym: "inhibition of lysine biosynthesis, aminoadipic acid pathway" NARROW [GOC:TermGenie] synonym: "inhibition of lysine biosynthesis, aminoadipic pathway" NARROW [GOC:TermGenie] synonym: "inhibition of lysine biosynthetic process via aminoadipic acid" NARROW [GOC:TermGenie] synonym: "inhibition of lysine biosynthetic process, aminoadipic acid pathway" NARROW [GOC:TermGenie] synonym: "inhibition of lysine biosynthetic process, aminoadipic pathway" NARROW [GOC:TermGenie] synonym: "inhibition of lysine formation via aminoadipic acid" NARROW [GOC:TermGenie] synonym: "inhibition of lysine synthesis via aminoadipic acid" NARROW [GOC:TermGenie] synonym: "negative regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] synonym: "negative regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid relationship: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid created_by: al creation_date: 2014-05-07T08:07:15Z [Term] id: GO:1902988 name: neurofibrillary tangle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle." [GO_REF:0000079, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780, PMID:24154541] comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). synonym: "flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] is_a: GO:0070841 ! inclusion body assembly created_by: sjp creation_date: 2014-05-08T09:19:51Z [Term] id: GO:1902989 name: meiotic telomere maintenance via semi-conservative replication namespace: biological_process def: "Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "equal telomere replication involved in meiotic cell cycle" RELATED [GOC:TermGenie] synonym: "telomeric fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie] synonym: "telomeric replication fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie] is_a: GO:0032201 ! telomere maintenance via semi-conservative replication is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0032201 ! telomere maintenance via semi-conservative replication intersection_of: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-08T11:13:43Z [Term] id: GO:1902990 name: mitotic telomere maintenance via semi-conservative replication namespace: biological_process def: "Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "equal telomere replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "telomeric fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "telomeric replication fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie] is_a: GO:0032201 ! telomere maintenance via semi-conservative replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0032201 ! telomere maintenance via semi-conservative replication intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-08T11:13:49Z [Term] id: GO:1902991 name: regulation of amyloid precursor protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] comment: An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay). synonym: "regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042987 ! amyloid precursor protein catabolic process relationship: regulates GO:0042987 ! amyloid precursor protein catabolic process created_by: rl creation_date: 2014-05-08T14:21:04Z [Term] id: GO:1902992 name: negative regulation of amyloid precursor protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] synonym: "down regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of APP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of APP catabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process relationship: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process created_by: rl creation_date: 2014-05-08T14:21:10Z [Term] id: GO:1902993 name: positive regulation of amyloid precursor protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] synonym: "activation of amyloid precursor protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of amyloid precursor protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of amyloid precursor protein degradation" NARROW [GOC:TermGenie] synonym: "activation of APP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of APP catabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of APP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of APP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of APP catabolism" EXACT [GOC:TermGenie] is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process relationship: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process created_by: rl creation_date: 2014-05-08T14:21:16Z [Term] id: GO:1902994 name: regulation of phospholipid efflux namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] synonym: "regulation of phospholipid export" EXACT [GOC:TermGenie] is_a: GO:2001138 ! regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033700 ! phospholipid efflux relationship: regulates GO:0033700 ! phospholipid efflux created_by: sjp creation_date: 2014-05-08T14:55:16Z [Term] id: GO:1902995 name: positive regulation of phospholipid efflux namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] synonym: "activation of phospholipid efflux" NARROW [GOC:TermGenie] synonym: "activation of phospholipid export" NARROW [GOC:TermGenie] synonym: "positive regulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipid export" EXACT [GOC:TermGenie] is_a: GO:1902994 ! regulation of phospholipid efflux is_a: GO:2001140 ! positive regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033700 ! phospholipid efflux relationship: positively_regulates GO:0033700 ! phospholipid efflux created_by: sjp creation_date: 2014-05-08T14:55:22Z [Term] id: GO:1902996 name: regulation of neurofibrillary tangle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] synonym: "regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] is_a: GO:0090083 ! regulation of inclusion body assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902988 ! neurofibrillary tangle assembly relationship: regulates GO:1902988 ! neurofibrillary tangle assembly created_by: sjp creation_date: 2014-05-08T15:44:27Z [Term] id: GO:1902997 name: negative regulation of neurofibrillary tangle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] synonym: "down regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "down regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "down regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "down regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "down regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "down regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "down-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "down-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "downregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "downregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "downregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "downregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "downregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "inhibition of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "inhibition of neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "inhibition of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "negative regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] is_a: GO:0090084 ! negative regulation of inclusion body assembly is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly relationship: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly created_by: sjp creation_date: 2014-05-08T15:44:33Z [Term] id: GO:1902998 name: positive regulation of neurofibrillary tangle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] synonym: "activation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "activation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "activation of neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "activation of neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "activation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "activation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "positive regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "up regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "up regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "up regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "up regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "up-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "up-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "upregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "upregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] synonym: "upregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] synonym: "upregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] synonym: "upregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] is_a: GO:0090261 ! positive regulation of inclusion body assembly is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902988 ! neurofibrillary tangle assembly relationship: positively_regulates GO:1902988 ! neurofibrillary tangle assembly created_by: sjp creation_date: 2014-05-08T15:44:45Z [Term] id: GO:1902999 name: negative regulation of phospholipid efflux namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] synonym: "down regulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "down regulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipid efflux" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipid export" EXACT [GOC:TermGenie] synonym: "inhibition of phospholipid efflux" NARROW [GOC:TermGenie] synonym: "inhibition of phospholipid export" NARROW [GOC:TermGenie] synonym: "negative regulation of phospholipid export" EXACT [GOC:TermGenie] is_a: GO:1902994 ! regulation of phospholipid efflux is_a: GO:2001139 ! negative regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033700 ! phospholipid efflux relationship: negatively_regulates GO:0033700 ! phospholipid efflux created_by: sjp creation_date: 2014-05-09T08:09:59Z [Term] id: GO:1903000 name: regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "regulation of lipid transport across blood brain barrier" EXACT [] is_a: GO:0032368 ! regulation of lipid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990379 ! lipid transport across blood-brain barrier relationship: regulates GO:1990379 ! lipid transport across blood-brain barrier created_by: sjp creation_date: 2014-05-09T09:30:04Z [Term] id: GO:1903001 name: negative regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "down regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "downregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "inhibition of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid transport across blood brain barrier" EXACT [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990379 ! lipid transport across blood-brain barrier relationship: negatively_regulates GO:1990379 ! lipid transport across blood-brain barrier created_by: sjp creation_date: 2014-05-09T09:30:10Z [Term] id: GO:1903002 name: positive regulation of lipid transport across blood-brain barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] synonym: "activation of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid transport across blood brain barrier" EXACT [] synonym: "up regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] synonym: "upregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990379 ! lipid transport across blood-brain barrier relationship: positively_regulates GO:1990379 ! lipid transport across blood-brain barrier created_by: sjp creation_date: 2014-05-09T09:30:16Z [Term] id: GO:1903003 name: positive regulation of protein deubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] synonym: "activation of deubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein deubiquitination" NARROW [GOC:TermGenie] synonym: "activation of protein deubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of protein deubiquitylation" NARROW [GOC:TermGenie] synonym: "positive regulation of deubiquitination" EXACT [GOC:TermGenie] synonym: "positive regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein deubiquitylation" EXACT [GOC:TermGenie] synonym: "up regulation of deubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein deubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein deubiquitylation" EXACT [GOC:TermGenie] synonym: "up-regulation of deubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein deubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein deubiquitylation" EXACT [GOC:TermGenie] synonym: "upregulation of deubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein deubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein deubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein deubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0090085 ! regulation of protein deubiquitination is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016579 ! protein deubiquitination relationship: positively_regulates GO:0016579 ! protein deubiquitination created_by: bf creation_date: 2014-05-12T15:39:10Z [Term] id: GO:1903004 name: regulation of protein K63-linked deubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] is_a: GO:0090085 ! regulation of protein deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070536 ! protein K63-linked deubiquitination relationship: regulates GO:0070536 ! protein K63-linked deubiquitination created_by: bf creation_date: 2014-05-12T15:40:43Z [Term] id: GO:1903005 name: negative regulation of protein K63-linked deubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] synonym: "down regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "inhibition of protein K63-linked deubiquitination" NARROW [GOC:TermGenie] is_a: GO:0090086 ! negative regulation of protein deubiquitination is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination relationship: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination created_by: bf creation_date: 2014-05-12T15:40:49Z [Term] id: GO:1903006 name: positive regulation of protein K63-linked deubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] synonym: "activation of protein K63-linked deubiquitination" NARROW [GOC:TermGenie] synonym: "up regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] is_a: GO:1903003 ! positive regulation of protein deubiquitination is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070536 ! protein K63-linked deubiquitination relationship: positively_regulates GO:0070536 ! protein K63-linked deubiquitination created_by: bf creation_date: 2014-05-12T15:40:55Z [Term] id: GO:1903007 name: positive regulation of Lys63-specific deubiquitinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] synonym: "activation of Lys63-specific deubiquitinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903006 ! positive regulation of protein K63-linked deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061578 ! Lys63-specific deubiquitinase activity relationship: positively_regulates GO:0061578 ! Lys63-specific deubiquitinase activity created_by: bf creation_date: 2014-05-12T15:47:35Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903009 name: proteasome complex disassembly namespace: biological_process def: "The disaggregation of a proteasome complex into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "26S proteasome disassembly" NARROW [GOC:TermGenie] synonym: "proteasome degradation" EXACT [] synonym: "proteasome disassembly" EXACT [GOC:TermGenie] is_a: GO:0032984 ! protein-containing complex disassembly created_by: jl creation_date: 2014-05-13T12:41:59Z [Term] id: GO:1903010 name: regulation of bone development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060348 ! bone development relationship: regulates GO:0060348 ! bone development created_by: mr creation_date: 2014-05-13T22:41:53Z [Term] id: GO:1903011 name: negative regulation of bone development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "down regulation of bone development" EXACT [GOC:TermGenie] synonym: "down-regulation of bone development" EXACT [GOC:TermGenie] synonym: "downregulation of bone development" EXACT [GOC:TermGenie] synonym: "inhibition of bone development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060348 ! bone development relationship: negatively_regulates GO:0060348 ! bone development created_by: mr creation_date: 2014-05-13T22:42:00Z [Term] id: GO:1903012 name: positive regulation of bone development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "activation of bone development" NARROW [GOC:TermGenie] synonym: "up regulation of bone development" EXACT [GOC:TermGenie] synonym: "up-regulation of bone development" EXACT [GOC:TermGenie] synonym: "upregulation of bone development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060348 ! bone development relationship: positively_regulates GO:0060348 ! bone development created_by: mr creation_date: 2014-05-13T22:42:06Z [Term] id: GO:1903013 name: response to differentiation-inducing factor 1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144] synonym: "DIF-1" RELATED [] synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT [] synonym: "response to DIF-1" RELATED [] synonym: "response to DIF1" RELATED [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:1901654 ! response to ketone created_by: rjd creation_date: 2014-05-14T16:18:11Z [Term] id: GO:1903014 name: cellular response to differentiation-inducing factor 1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144] synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT [] synonym: "cellular response to DIF-1" RELATED [] synonym: "cellular response to DIF1" RELATED [] synonym: "DIF-1" RELATED [] is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1903013 ! response to differentiation-inducing factor 1 created_by: rjd creation_date: 2014-05-14T16:18:18Z [Term] id: GO:1903015 name: regulation of exo-alpha-sialidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) synonym: "regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "regulation of sialidase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004308 ! exo-alpha-sialidase activity relationship: regulates GO:0004308 ! exo-alpha-sialidase activity created_by: rl creation_date: 2014-05-14T18:15:11Z [Term] id: GO:1903016 name: negative regulation of exo-alpha-sialidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) synonym: "down regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "inhibition of acetylneuraminidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of alpha-neuraminidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of exo-alpha-sialidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of neuraminidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sialidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of sialidase activity" EXACT [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity relationship: negatively_regulates GO:0004308 ! exo-alpha-sialidase activity created_by: rl creation_date: 2014-05-14T18:15:17Z [Term] id: GO:1903017 name: positive regulation of exo-alpha-sialidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) synonym: "activation of acetylneuraminidase activity" NARROW [GOC:TermGenie] synonym: "activation of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of alpha-neuraminidase activity" NARROW [GOC:TermGenie] synonym: "activation of exo-alpha-sialidase activity" NARROW [GOC:TermGenie] synonym: "activation of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of neuraminidase activity" NARROW [GOC:TermGenie] synonym: "activation of sialidase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of sialidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of neuraminidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of sialidase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004308 ! exo-alpha-sialidase activity relationship: positively_regulates GO:0004308 ! exo-alpha-sialidase activity created_by: rl creation_date: 2014-05-14T18:15:23Z [Term] id: GO:1903018 name: regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009100 ! glycoprotein metabolic process relationship: regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:19Z [Term] id: GO:1903019 name: negative regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:25Z [Term] id: GO:1903020 name: positive regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009100 ! glycoprotein metabolic process relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process created_by: rl creation_date: 2014-05-14T18:44:31Z [Term] id: GO:1903021 name: regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands relationship: regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands created_by: tb creation_date: 2014-05-14T23:44:35Z [Term] id: GO:1903022 name: positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046] synonym: "activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" NARROW [GOC:TermGenie] synonym: "up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] synonym: "upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903021 ! regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands relationship: positively_regulates GO:0090580 ! phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands created_by: tb creation_date: 2014-05-14T23:44:47Z [Term] id: GO:1903023 name: regulation of ascospore-type prospore membrane assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ascospore-type prospore membrane assembly." [GO_REF:0000058, GOC:TermGenie, PMID:11405625] synonym: "regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of forespore membrane formation" EXACT [GOC:TermGenie] synonym: "regulation of FSM assembly" EXACT [GOC:TermGenie] synonym: "regulation of FSM biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of FSM formation" EXACT [GOC:TermGenie] is_a: GO:0034307 ! regulation of ascospore formation is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032120 ! ascospore-type prospore membrane assembly relationship: regulates GO:0032120 ! ascospore-type prospore membrane assembly created_by: al creation_date: 2014-05-15T08:51:51Z [Term] id: GO:1903024 name: positive regulation of ascospore-type prospore membrane assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ascospore-type prospore membrane assembly." [GO_REF:0000058, GOC:TermGenie, PMID:11405625] synonym: "activation of ascospore-type prospore membrane assembly" NARROW [GOC:TermGenie] synonym: "activation of forespore membrane biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of forespore membrane formation" NARROW [GOC:TermGenie] synonym: "activation of FSM assembly" NARROW [GOC:TermGenie] synonym: "activation of FSM biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of FSM formation" NARROW [GOC:TermGenie] synonym: "positive regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of forespore membrane formation" EXACT [GOC:TermGenie] synonym: "positive regulation of FSM assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of FSM biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of FSM formation" EXACT [GOC:TermGenie] synonym: "up regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] synonym: "up regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of forespore membrane formation" EXACT [GOC:TermGenie] synonym: "up regulation of FSM assembly" EXACT [GOC:TermGenie] synonym: "up regulation of FSM biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of FSM formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of forespore membrane formation" EXACT [GOC:TermGenie] synonym: "up-regulation of FSM assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of FSM biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of FSM formation" EXACT [GOC:TermGenie] synonym: "upregulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] synonym: "upregulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of forespore membrane formation" EXACT [GOC:TermGenie] synonym: "upregulation of FSM assembly" EXACT [GOC:TermGenie] synonym: "upregulation of FSM biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of FSM formation" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0075296 ! positive regulation of ascospore formation is_a: GO:1903023 ! regulation of ascospore-type prospore membrane assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032120 ! ascospore-type prospore membrane assembly relationship: positively_regulates GO:0032120 ! ascospore-type prospore membrane assembly created_by: al creation_date: 2014-05-15T08:51:58Z [Term] id: GO:1903025 name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326] is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding relationship: regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding created_by: dph creation_date: 2014-05-15T17:55:54Z [Term] id: GO:1903026 name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326] synonym: "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding relationship: negatively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding created_by: dph creation_date: 2014-05-15T17:56:00Z [Term] id: GO:1903027 name: regulation of opsonization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008228 ! opsonization relationship: regulates GO:0008228 ! opsonization created_by: rl creation_date: 2014-05-16T17:34:41Z [Term] id: GO:1903028 name: positive regulation of opsonization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221] synonym: "activation of opsonization" NARROW [GOC:TermGenie] synonym: "up regulation of opsonization" EXACT [GOC:TermGenie] synonym: "up-regulation of opsonization" EXACT [GOC:TermGenie] synonym: "upregulation of opsonization" EXACT [GOC:TermGenie] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:1903027 ! regulation of opsonization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008228 ! opsonization relationship: positively_regulates GO:0008228 ! opsonization created_by: rl creation_date: 2014-05-16T17:34:54Z [Term] id: GO:1903031 name: regulation of microtubule plus-end binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] is_a: GO:1904526 ! regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051010 ! microtubule plus-end binding relationship: regulates GO:0051010 ! microtubule plus-end binding created_by: hjd creation_date: 2014-05-16T18:38:26Z [Term] id: GO:1903032 name: negative regulation of microtubule plus-end binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] synonym: "down regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule plus-end binding" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule plus-end binding" NARROW [GOC:TermGenie] is_a: GO:1903031 ! regulation of microtubule plus-end binding is_a: GO:1904527 ! negative regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051010 ! microtubule plus-end binding relationship: negatively_regulates GO:0051010 ! microtubule plus-end binding created_by: hjd creation_date: 2014-05-16T18:38:32Z [Term] id: GO:1903033 name: positive regulation of microtubule plus-end binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] synonym: "activation of microtubule plus-end binding" NARROW [GOC:TermGenie] synonym: "up regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule plus-end binding" EXACT [GOC:TermGenie] is_a: GO:1903031 ! regulation of microtubule plus-end binding is_a: GO:1904528 ! positive regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051010 ! microtubule plus-end binding relationship: positively_regulates GO:0051010 ! microtubule plus-end binding created_by: hjd creation_date: 2014-05-16T18:38:38Z [Term] id: GO:1903034 name: regulation of response to wounding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009611 ! response to wounding relationship: regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:46Z [Term] id: GO:1903035 name: negative regulation of response to wounding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie] synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009611 ! response to wounding relationship: negatively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:52Z [Term] id: GO:1903036 name: positive regulation of response to wounding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie] synonym: "activation of response to wounding" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie] synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903034 ! regulation of response to wounding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009611 ! response to wounding relationship: positively_regulates GO:0009611 ! response to wounding created_by: kmv creation_date: 2014-05-18T01:28:58Z [Term] id: GO:1903037 name: regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007159 ! leukocyte cell-cell adhesion relationship: regulates GO:0007159 ! leukocyte cell-cell adhesion created_by: rl creation_date: 2014-05-19T15:29:58Z [Term] id: GO:1903038 name: negative regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion relationship: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion created_by: rl creation_date: 2014-05-19T15:30:05Z [Term] id: GO:1903039 name: positive regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion relationship: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion created_by: rl creation_date: 2014-05-19T15:30:15Z [Term] id: GO:1903040 name: exon-exon junction complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:17606899] synonym: "EJC assembly" EXACT [GOC:TermGenie] synonym: "EJC formation" EXACT [GOC:TermGenie] synonym: "exon-exon junction complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: sart creation_date: 2014-05-20T14:52:07Z [Term] id: GO:1903041 name: regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003415 ! chondrocyte hypertrophy relationship: regulates GO:0003415 ! chondrocyte hypertrophy created_by: mr creation_date: 2014-05-20T21:23:13Z [Term] id: GO:1903042 name: negative regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] synonym: "down regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of chondrocyte hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061182 ! negative regulation of chondrocyte development is_a: GO:1903041 ! regulation of chondrocyte hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003415 ! chondrocyte hypertrophy relationship: negatively_regulates GO:0003415 ! chondrocyte hypertrophy created_by: mr creation_date: 2014-05-20T21:23:19Z [Term] id: GO:1903043 name: positive regulation of chondrocyte hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] synonym: "activation of chondrocyte hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1902761 ! positive regulation of chondrocyte development is_a: GO:1903041 ! regulation of chondrocyte hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003415 ! chondrocyte hypertrophy relationship: positively_regulates GO:0003415 ! chondrocyte hypertrophy created_by: mr creation_date: 2014-05-20T21:23:25Z [Term] id: GO:1903044 name: protein localization to membrane raft namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a membrane raft." [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744] synonym: "protein localisation in membrane raft" EXACT [GOC:TermGenie] synonym: "protein localisation to membrane raft" EXACT [GOC:TermGenie] synonym: "protein localization in membrane raft" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane created_by: dl creation_date: 2014-05-21T10:49:03Z [Term] id: GO:1903045 name: neural crest cell migration involved in sympathetic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129] comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: part_of GO:0048485 ! sympathetic nervous system development relationship: part_of GO:0048485 ! sympathetic nervous system development created_by: rl creation_date: 2014-05-22T07:06:02Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903048 name: regulation of acetylcholine-gated cation channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690] is_a: GO:0098815 ! modulation of excitatory postsynaptic potential is_a: GO:0098962 ! regulation of postsynaptic neurotransmitter receptor activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022848 ! acetylcholine-gated cation-selective channel activity relationship: regulates GO:0022848 ! acetylcholine-gated cation-selective channel activity created_by: bf creation_date: 2014-05-22T14:46:53Z [Term] id: GO:1903049 name: negative regulation of acetylcholine-gated cation channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690] synonym: "down regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of acetylcholine-gated cation channel activity" NARROW [GOC:TermGenie] is_a: GO:0090394 ! negative regulation of excitatory postsynaptic potential is_a: GO:1903048 ! regulation of acetylcholine-gated cation channel activity is_a: GO:2000272 ! negative regulation of signaling receptor activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022848 ! acetylcholine-gated cation-selective channel activity relationship: negatively_regulates GO:0022848 ! acetylcholine-gated cation-selective channel activity created_by: bf creation_date: 2014-05-22T14:47:00Z [Term] id: GO:1903050 name: regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP) synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process created_by: rl creation_date: 2014-05-22T18:00:45Z [Term] id: GO:1903051 name: negative regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP). synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process is_a: GO:1903363 ! negative regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process created_by: rl creation_date: 2014-05-22T18:00:51Z [Term] id: GO:1903052 name: positive regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP) synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process is_a: GO:1903364 ! positive regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process created_by: rl creation_date: 2014-05-22T18:00:57Z [Term] id: GO:1903053 name: regulation of extracellular matrix organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030198 ! extracellular matrix organization relationship: regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:41Z [Term] id: GO:1903054 name: negative regulation of extracellular matrix organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030198 ! extracellular matrix organization relationship: negatively_regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:47Z [Term] id: GO:1903055 name: positive regulation of extracellular matrix organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030198 ! extracellular matrix organization relationship: positively_regulates GO:0030198 ! extracellular matrix organization created_by: rl creation_date: 2014-05-23T17:15:53Z [Term] id: GO:1903056 name: regulation of melanosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles synonym: "regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032438 ! melanosome organization relationship: regulates GO:0032438 ! melanosome organization created_by: rl creation_date: 2014-05-27T13:27:49Z [Term] id: GO:1903057 name: negative regulation of melanosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. synonym: "down regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of melanosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of melanosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1903056 ! regulation of melanosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032438 ! melanosome organization relationship: negatively_regulates GO:0032438 ! melanosome organization created_by: rl creation_date: 2014-05-27T13:27:55Z [Term] id: GO:1903058 name: positive regulation of melanosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. synonym: "activation of melanosome organisation" NARROW [GOC:TermGenie] synonym: "activation of melanosome organization" NARROW [GOC:TermGenie] synonym: "activation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of melanosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1903056 ! regulation of melanosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032438 ! melanosome organization relationship: positively_regulates GO:0032438 ! melanosome organization created_by: rl creation_date: 2014-05-27T13:28:01Z [Term] id: GO:1903059 name: regulation of protein lipidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] synonym: "regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0050746 ! regulation of lipoprotein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006497 ! protein lipidation relationship: regulates GO:0006497 ! protein lipidation created_by: rph creation_date: 2014-05-28T13:21:18Z [Term] id: GO:1903060 name: negative regulation of protein lipidation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] synonym: "down regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "down regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "down regulation of protein lipidation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein lipidation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "downregulation of protein lipidation" EXACT [GOC:TermGenie] synonym: "inhibition of lipid:protein modification" NARROW [GOC:TermGenie] synonym: "inhibition of protein amino acid lipidation" NARROW [GOC:TermGenie] synonym: "inhibition of protein lipidation" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "negative regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process is_a: GO:1903059 ! regulation of protein lipidation is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006497 ! protein lipidation relationship: negatively_regulates GO:0006497 ! protein lipidation created_by: rph creation_date: 2014-05-28T13:21:25Z [Term] id: GO:1903061 name: positive regulation of protein lipidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] synonym: "activation of lipid:protein modification" NARROW [GOC:TermGenie] synonym: "activation of protein amino acid lipidation" NARROW [GOC:TermGenie] synonym: "activation of protein lipidation" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "positive regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "up regulation of protein lipidation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein lipidation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid:protein modification" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid lipidation" EXACT [GOC:TermGenie] synonym: "upregulation of protein lipidation" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0050747 ! positive regulation of lipoprotein metabolic process is_a: GO:1903059 ! regulation of protein lipidation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006497 ! protein lipidation relationship: positively_regulates GO:0006497 ! protein lipidation created_by: rph creation_date: 2014-05-28T13:21:31Z [Term] id: GO:1903062 name: regulation of reverse cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] is_a: GO:0032374 ! regulation of cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043691 ! reverse cholesterol transport relationship: regulates GO:0043691 ! reverse cholesterol transport created_by: rl creation_date: 2014-05-28T15:15:27Z [Term] id: GO:1903063 name: negative regulation of reverse cholesterol transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] synonym: "down regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] synonym: "down-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] synonym: "downregulation of reverse cholesterol transport" EXACT [GOC:TermGenie] synonym: "inhibition of reverse cholesterol transport" NARROW [GOC:TermGenie] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:1903062 ! regulation of reverse cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043691 ! reverse cholesterol transport relationship: negatively_regulates GO:0043691 ! reverse cholesterol transport created_by: rl creation_date: 2014-05-28T15:15:34Z [Term] id: GO:1903064 name: positive regulation of reverse cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] synonym: "activation of reverse cholesterol transport" NARROW [GOC:TermGenie] synonym: "up regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] synonym: "up-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] synonym: "upregulation of reverse cholesterol transport" EXACT [GOC:TermGenie] is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:1903062 ! regulation of reverse cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043691 ! reverse cholesterol transport relationship: positively_regulates GO:0043691 ! reverse cholesterol transport created_by: rl creation_date: 2014-05-28T15:15:40Z [Term] id: GO:1903065 name: obsolete protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape namespace: biological_process def: "OBSOLETE. Any protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [] is_obsolete: true created_by: vw creation_date: 2014-05-28T15:29:27Z [Term] id: GO:1903066 name: regulation of protein localization to cell tip namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] synonym: "regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990151 ! protein localization to cell tip relationship: regulates GO:1990151 ! protein localization to cell tip created_by: vw creation_date: 2014-05-28T15:48:42Z [Term] id: GO:1903067 name: negative regulation of protein localization to cell tip namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] synonym: "down regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell tip" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell tip" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell tip" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell tip" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell tip" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] is_a: GO:1903066 ! regulation of protein localization to cell tip is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990151 ! protein localization to cell tip relationship: negatively_regulates GO:1990151 ! protein localization to cell tip created_by: vw creation_date: 2014-05-28T15:48:48Z [Term] id: GO:1903068 name: positive regulation of protein localization to cell tip namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] synonym: "activation of protein localisation to cell tip" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell tip" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell tip" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell tip" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell tip" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell tip" EXACT [GOC:TermGenie] is_a: GO:1903066 ! regulation of protein localization to cell tip is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990151 ! protein localization to cell tip relationship: positively_regulates GO:1990151 ! protein localization to cell tip created_by: vw creation_date: 2014-05-28T15:48:54Z [Term] id: GO:1903069 name: regulation of ER-associated ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] synonym: "regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of ERAD" EXACT [GOC:TermGenie] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1904292 ! regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030433 ! ubiquitin-dependent ERAD pathway relationship: regulates GO:0030433 ! ubiquitin-dependent ERAD pathway created_by: rph creation_date: 2014-05-28T17:53:46Z [Term] id: GO:1903070 name: negative regulation of ER-associated ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] synonym: "down regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ERAD" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ERAD" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ERAD" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ER-associated protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of ER-associated protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ER-associated protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ER-associated protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ERAD" NARROW [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of ERAD" EXACT [GOC:TermGenie] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process is_a: GO:1904293 ! negative regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway relationship: negatively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway created_by: rph creation_date: 2014-05-28T17:53:53Z [Term] id: GO:1903071 name: positive regulation of ER-associated ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] synonym: "activation of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of ER-associated protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of ER-associated protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ER-associated protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of ER-associated protein degradation" NARROW [GOC:TermGenie] synonym: "activation of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ERAD" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of ERAD" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ERAD" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ERAD" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ER-associated protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ERAD" EXACT [GOC:TermGenie] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process is_a: GO:1904294 ! positive regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway relationship: positively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway created_by: rph creation_date: 2014-05-28T17:54:04Z [Term] id: GO:1903072 name: regulation of death-inducing signaling complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] synonym: "regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] synonym: "regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of DISC assembly" EXACT [GOC:TermGenie] synonym: "regulation of DISC formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071550 ! death-inducing signaling complex assembly relationship: regulates GO:0071550 ! death-inducing signaling complex assembly created_by: bf creation_date: 2014-05-29T09:33:13Z [Term] id: GO:1903073 name: negative regulation of death-inducing signaling complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] synonym: "down regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] synonym: "down regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of DISC assembly" EXACT [GOC:TermGenie] synonym: "down regulation of DISC formation" EXACT [GOC:TermGenie] synonym: "down-regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of DISC assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of DISC formation" EXACT [GOC:TermGenie] synonym: "downregulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] synonym: "downregulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of DISC assembly" EXACT [GOC:TermGenie] synonym: "downregulation of DISC formation" EXACT [GOC:TermGenie] synonym: "inhibition of DD-mediated complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of death domain-mediated complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" NARROW [GOC:TermGenie] synonym: "inhibition of death-inducing signaling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of death-inducing signaling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of death-inducing signalling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of DISC assembly" NARROW [GOC:TermGenie] synonym: "inhibition of DISC formation" NARROW [GOC:TermGenie] synonym: "negative regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of DISC assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of DISC formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1903072 ! regulation of death-inducing signaling complex assembly is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly relationship: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly created_by: bf creation_date: 2014-05-29T09:33:20Z [Term] id: GO:1903074 name: TRAIL death-inducing signaling complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] synonym: "TRAIL death-inducing signaling complex formation" EXACT [GOC:TermGenie] synonym: "TRAIL death-inducing signalling complex assembly" EXACT [GOC:TermGenie] synonym: "TRAIL death-inducing signalling complex formation" EXACT [GOC:TermGenie] synonym: "TRAIL DISC assembly" EXACT [GOC:TermGenie] synonym: "TRAIL DISC formation" EXACT [GOC:TermGenie] is_a: GO:0071550 ! death-inducing signaling complex assembly relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway created_by: bf creation_date: 2014-05-29T09:47:39Z [Term] id: GO:1903075 name: pyridoxine import across plasma membrane namespace: biological_process def: "The directed movement of pyridoxine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:15701794] synonym: "pyridoxine import into cell" EXACT [] is_a: GO:0098739 ! import across plasma membrane is_a: GO:1903092 ! pyridoxine transmembrane transport created_by: mah creation_date: 2014-05-29T15:04:14Z [Term] id: GO:1903076 name: regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090003 alt_id: GO:1905963 def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to plasma membrane" RELATED [] synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072659 ! protein localization to plasma membrane relationship: regulates GO:0072659 ! protein localization to plasma membrane created_by: tanyaberardini creation_date: 2009-07-10T10:32:44Z [Term] id: GO:1903077 name: negative regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090005 alt_id: GO:1905964 def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072659 ! protein localization to plasma membrane relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane created_by: tanyaberardini creation_date: 2014-05-29T17:10:16Z [Term] id: GO:1903078 name: positive regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090004 alt_id: GO:1905965 def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072659 ! protein localization to plasma membrane relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane created_by: tanyaberardini creation_date: 2009-07-10T10:34:17Z [Term] id: GO:1903079 name: obsolete negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape namespace: biological_process def: "OBSOLETE. Any negative regulation of protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [] is_obsolete: true created_by: vw creation_date: 2014-05-29T17:42:24Z [Term] id: GO:1903080 name: regulation of C-C chemokine receptor CCR7 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway relationship: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway created_by: rl creation_date: 2014-05-29T18:32:49Z [Term] id: GO:1903081 name: negative regulation of C-C chemokine receptor CCR7 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0070100 ! negative regulation of chemokine-mediated signaling pathway is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway relationship: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway created_by: rl creation_date: 2014-05-29T18:32:55Z [Term] id: GO:1903082 name: positive regulation of C-C chemokine receptor CCR7 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie] synonym: "activation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] is_a: GO:0070101 ! positive regulation of chemokine-mediated signaling pathway is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway relationship: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway created_by: rl creation_date: 2014-05-29T18:33:01Z [Term] id: GO:1903083 name: protein localization to condensed chromosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] synonym: "protein localisation in condensed chromosome" EXACT [GOC:TermGenie] synonym: "protein localisation to condensed chromosome" EXACT [GOC:TermGenie] synonym: "protein localization in condensed chromosome" EXACT [GOC:TermGenie] is_a: GO:0034502 ! protein localization to chromosome created_by: kmv creation_date: 2014-05-29T20:31:25Z [Term] id: GO:1903084 name: protein localization to condensed nuclear chromosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] synonym: "protein localisation in condensed nuclear chromosome" EXACT [GOC:TermGenie] synonym: "protein localisation to condensed nuclear chromosome" EXACT [GOC:TermGenie] synonym: "protein localization in condensed nuclear chromosome" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus is_a: GO:1903083 ! protein localization to condensed chromosome created_by: kmv creation_date: 2014-05-29T20:33:17Z [Term] id: GO:1903085 name: regulation of sinapate ester biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161] synonym: "regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] synonym: "regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of sinapate ester formation" EXACT [GOC:TermGenie] synonym: "regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033525 ! sinapate ester biosynthetic process relationship: regulates GO:0033525 ! sinapate ester biosynthetic process created_by: tb creation_date: 2014-05-30T22:00:12Z [Term] id: GO:1903086 name: negative regulation of sinapate ester biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161] synonym: "down regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of sinapate ester formation" EXACT [GOC:TermGenie] synonym: "down regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of sinapate ester formation" EXACT [GOC:TermGenie] synonym: "down-regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sinapate ester anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of sinapate ester formation" EXACT [GOC:TermGenie] synonym: "downregulation of sinapate ester synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of sinapate ester anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of sinapate ester biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of sinapate ester biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of sinapate ester formation" NARROW [GOC:TermGenie] synonym: "inhibition of sinapate ester synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of sinapate ester formation" EXACT [GOC:TermGenie] synonym: "negative regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1903085 ! regulation of sinapate ester biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process relationship: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process created_by: tb creation_date: 2014-05-30T22:00:18Z [Term] id: GO:1903087 name: mitotic spindle pole body duplication namespace: biological_process def: "Any spindle pole body duplication that is involved in the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "spindle pole body assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body biogenesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body duplication in cytoplasm involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body duplication involved in mitotic cell cycle" EXACT [] synonym: "spindle pole body formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "spindle pole body replication involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0030474 ! spindle pole body duplication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030474 ! spindle pole body duplication intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-06-02T16:45:56Z [Term] id: GO:1903088 name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport namespace: biological_process def: "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport created_by: mcc creation_date: 2014-06-02T20:34:58Z [Term] id: GO:1903089 name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other." [GO_REF:0000066, GOC:TermGenie, PMID:24778186] synonym: "acadesine transporter activity" EXACT [] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:1903088 ! 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport created_by: mcc creation_date: 2014-06-02T20:37:17Z [Term] id: GO:1903090 name: pyridoxal transmembrane transport namespace: biological_process def: "The process in which pyridoxal is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031920 ! pyridoxal transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0098655 ! cation transmembrane transport created_by: al creation_date: 2014-06-03T10:41:13Z [Term] id: GO:1903091 name: pyridoxamine transmembrane transport namespace: biological_process def: "The process in which pyridoxamine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031922 ! pyridoxamine transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0072488 ! ammonium transmembrane transport created_by: al creation_date: 2014-06-03T10:41:20Z [Term] id: GO:1903092 name: pyridoxine transmembrane transport namespace: biological_process def: "The process in which pyridoxine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031923 ! pyridoxine transport is_a: GO:0035461 ! vitamin transmembrane transport created_by: al creation_date: 2014-06-03T10:41:26Z [Term] id: GO:1903093 name: regulation of protein K48-linked deubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] is_a: GO:0090085 ! regulation of protein deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071108 ! protein K48-linked deubiquitination relationship: regulates GO:0071108 ! protein K48-linked deubiquitination created_by: bf creation_date: 2014-06-03T12:27:48Z [Term] id: GO:1903094 name: negative regulation of protein K48-linked deubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510] synonym: "down regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] synonym: "inhibition of protein K48-linked deubiquitination" NARROW [GOC:TermGenie] is_a: GO:0090086 ! negative regulation of protein deubiquitination is_a: GO:1903093 ! regulation of protein K48-linked deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination relationship: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination created_by: bf creation_date: 2014-06-03T12:27:54Z [Term] id: GO:1903095 name: ribonuclease III complex namespace: cellular_component def: "A protein complex which is capable of ribonuclease III activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22393237] comment: An example of this is RNC in human (Q9NRR4) in PMID:22393237 (inferred from direct assay). is_a: GO:1902555 ! endoribonuclease complex created_by: bhm creation_date: 2014-06-03T15:06:39Z [Term] id: GO:1903096 name: protein localization to meiotic spindle midzone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] synonym: "protein localisation in meiotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localisation to meiotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localization in meiotic spindle midzone" EXACT [GOC:TermGenie] is_a: GO:1905359 ! protein localization to meiotic spindle created_by: kmv creation_date: 2014-06-03T16:06:22Z [Term] id: GO:1903097 name: regulation of CENP-A containing nucleosome assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] synonym: "regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] is_a: GO:0010847 ! regulation of chromatin assembly is_a: GO:0090230 ! regulation of centromere complex assembly is_a: GO:1900049 ! regulation of histone exchange intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034080 ! CENP-A containing nucleosome assembly relationship: regulates GO:0034080 ! CENP-A containing nucleosome assembly created_by: vw creation_date: 2014-06-03T16:15:30Z [Term] id: GO:1903098 name: negative regulation of CENP-A containing nucleosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] synonym: "down regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "down regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "down regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "down regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "down regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "down regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "down regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "down regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "down-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "down-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "down-regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "down-regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "down-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "down-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "down-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "downregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "downregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "downregulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "downregulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "downregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "downregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "downregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "inhibition of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "inhibition of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie] synonym: "inhibition of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "inhibition of CENP-A loading" RELATED [GOC:TermGenie] synonym: "inhibition of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "inhibition of centromere-specific histone exchange" NARROW [GOC:TermGenie] synonym: "inhibition of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie] synonym: "inhibition of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie] synonym: "negative regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "negative regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "negative regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "negative regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "negative regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "negative regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly is_a: GO:1900050 ! negative regulation of histone exchange is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034080 ! CENP-A containing nucleosome assembly relationship: negatively_regulates GO:0034080 ! CENP-A containing nucleosome assembly created_by: vw creation_date: 2014-06-03T16:15:36Z [Term] id: GO:1903099 name: positive regulation of CENP-A containing nucleosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] synonym: "activation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "activation of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie] synonym: "activation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "activation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "activation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "activation of centromere-specific histone exchange" NARROW [GOC:TermGenie] synonym: "activation of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie] synonym: "activation of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie] synonym: "activation of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie] synonym: "positive regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "positive regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "positive regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "positive regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "positive regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "positive regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "up regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "up regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "up regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "up regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "up regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "up regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "up regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "up regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "up regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "up-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "up-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "up-regulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "up-regulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "up-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "up-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "up-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "upregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] synonym: "upregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] synonym: "upregulation of CENP-A deposition" RELATED [GOC:TermGenie] synonym: "upregulation of CENP-A loading" RELATED [GOC:TermGenie] synonym: "upregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] synonym: "upregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] synonym: "upregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly is_a: GO:1900051 ! positive regulation of histone exchange is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034080 ! CENP-A containing nucleosome assembly relationship: positively_regulates GO:0034080 ! CENP-A containing nucleosome assembly created_by: vw creation_date: 2014-06-03T16:15:42Z [Term] id: GO:1903100 name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0046488 ! phosphatidylinositol metabolic process created_by: bhm creation_date: 2014-06-04T14:14:24Z [Term] id: GO:1903101 name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation" EXACT [GOC:TermGenie] is_a: GO:0031161 ! phosphatidylinositol catabolic process is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process created_by: bhm creation_date: 2014-06-04T14:14:30Z [Term] id: GO:1903102 name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation" EXACT [GOC:TermGenie] synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006661 ! phosphatidylinositol biosynthetic process is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process created_by: bhm creation_date: 2014-06-04T14:14:36Z [Term] id: GO:1903103 name: potassium:proton antiporter complex namespace: cellular_component def: "A protein complex which is capable of potassium:proton antiporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:21041667] comment: An example of this is kefC in E. coli (P03819) in PMID:21041667 (inferred from direct assay). is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2014-06-04T20:51:33Z [Term] id: GO:1903104 name: regulation of insulin receptor signaling pathway involved in determination of adult lifespan namespace: biological_process def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] synonym: "regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] is_a: GO:0046626 ! regulation of insulin receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan relationship: regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan created_by: kmv creation_date: 2014-06-05T20:56:06Z [Term] id: GO:1903105 name: negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] synonym: "down regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "down regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "down regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "down regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "down-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "down-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "downregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "downregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "downregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "downregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "inhibition of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "inhibition of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "inhibition of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "inhibition of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "negative regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "negative regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan relationship: negatively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan created_by: kmv creation_date: 2014-06-05T20:56:12Z [Term] id: GO:1903106 name: positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] synonym: "activation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "activation of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "activation of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "activation of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "positive regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "positive regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "up regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "up-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "upregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] synonym: "upregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "upregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] synonym: "upregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan relationship: positively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan created_by: kmv creation_date: 2014-06-05T20:56:19Z [Term] id: GO:1903107 name: insulin receptor signaling pathway involved in dauer larval development namespace: biological_process def: "Any insulin receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19853560] synonym: "daf-2 receptor signaling pathway involved in dauer larval development" NARROW [GOC:TermGenie] synonym: "insulin receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] is_a: GO:0008286 ! insulin receptor signaling pathway intersection_of: GO:0008286 ! insulin receptor signaling pathway intersection_of: part_of GO:0040024 ! dauer larval development relationship: part_of GO:0040024 ! dauer larval development created_by: kmv creation_date: 2014-06-05T21:30:03Z [Term] id: GO:1903108 name: regulation of mitochondrial transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] synonym: "regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "regulation of transcription from mitochondrial promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0062125 ! regulation of mitochondrial gene expression intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006390 ! mitochondrial transcription relationship: regulates GO:0006390 ! mitochondrial transcription created_by: al creation_date: 2014-06-09T11:53:14Z [Term] id: GO:1903109 name: positive regulation of mitochondrial transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] synonym: "activation of mitochondrial transcription" NARROW [GOC:TermGenie] synonym: "activation of transcription from mitochondrial promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from mitochondrial promoter" EXACT [] synonym: "up regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial transcription" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1903108 ! regulation of mitochondrial transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006390 ! mitochondrial transcription relationship: positively_regulates GO:0006390 ! mitochondrial transcription created_by: al creation_date: 2014-06-09T11:53:20Z [Term] id: GO:1903110 name: regulation of single-strand break repair via homologous recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:1903516 ! regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990396 ! single-strand break repair via homologous recombination relationship: regulates GO:1990396 ! single-strand break repair via homologous recombination created_by: pr creation_date: 2014-06-09T12:11:26Z [Term] id: GO:1903111 name: negative regulation of single-strand break repair via homologous recombination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] synonym: "down regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "down-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "downregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "inhibition of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie] is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination is_a: GO:1903517 ! negative regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination relationship: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination created_by: pr creation_date: 2014-06-09T12:11:32Z [Term] id: GO:1903112 name: positive regulation of single-strand break repair via homologous recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] synonym: "activation of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie] synonym: "up regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "up-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "upregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination is_a: GO:1903518 ! positive regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination relationship: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination created_by: pr creation_date: 2014-06-09T12:11:38Z [Term] id: GO:1903113 name: copper ion transmembrane transporter complex namespace: cellular_component def: "A protein complex which is capable of copper ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23122209] comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209 (inferred from direct assay). is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2014-06-10T09:54:48Z [Term] id: GO:1903114 name: silver ion transmembrane transporter complex namespace: cellular_component def: "A protein complex which is capable of silver ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11283292] comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:11283292 (inferred from direct assay). is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2014-06-10T10:00:02Z [Term] id: GO:1903115 name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030048 ! actin filament-based movement relationship: regulates GO:0030048 ! actin filament-based movement created_by: al creation_date: 2014-06-12T16:55:57Z [Term] id: GO:1903116 name: positive regulation of actin filament-based movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030048 ! actin filament-based movement relationship: positively_regulates GO:0030048 ! actin filament-based movement created_by: al creation_date: 2014-06-12T16:56:04Z [Term] id: GO:1903117 name: regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "regulation of actin filament organisation of constriction ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organisation of contractile ring assembly" EXACT [GOC:TermGenie] synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organization of constriction ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organization of contractile ring assembly" EXACT [GOC:TermGenie] synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] synonym: "regulation of actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of constriction ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of contractile ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] synonym: "regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] is_a: GO:0110053 ! regulation of actin filament organization is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000689 ! actomyosin contractile ring assembly actin filament organization relationship: regulates GO:2000689 ! actomyosin contractile ring assembly actin filament organization created_by: al creation_date: 2014-06-12T16:57:17Z [Term] id: GO:1903118 name: urate homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of urate within an organism or cell." [GO_REF:0000072, GOC:dph, GOC:TermGenie, PMID:22306318] is_a: GO:0048878 ! chemical homeostasis created_by: dph creation_date: 2014-06-13T14:54:51Z [Term] id: GO:1903119 name: protein localization to actin cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton created_by: mah creation_date: 2014-06-16T11:27:09Z [Term] id: GO:1903120 name: protein localization to actin filament bundle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization to actin cable" RELATED [GOC:mah] is_a: GO:1903119 ! protein localization to actin cytoskeleton created_by: mah creation_date: 2014-06-16T11:27:16Z [Term] id: GO:1903121 name: regulation of TRAIL-activated apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway relationship: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway created_by: bf creation_date: 2014-06-17T12:39:15Z [Term] id: GO:1903122 name: negative regulation of TRAIL-activated apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] synonym: "down regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway relationship: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway created_by: bf creation_date: 2014-06-17T12:39:21Z [Term] id: GO:1903123 name: regulation of thioredoxin peroxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of TPx activity" EXACT [GOC:TermGenie] synonym: "regulation of TrxPx activity" EXACT [GOC:TermGenie] is_a: GO:2000468 ! regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008379 ! thioredoxin peroxidase activity relationship: regulates GO:0008379 ! thioredoxin peroxidase activity created_by: bf creation_date: 2014-06-18T11:03:11Z [Term] id: GO:1903124 name: negative regulation of thioredoxin peroxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687] synonym: "down regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of TPx activity" EXACT [GOC:TermGenie] synonym: "down regulation of TrxPx activity" EXACT [GOC:TermGenie] synonym: "down-regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of TPx activity" EXACT [GOC:TermGenie] synonym: "down-regulation of TrxPx activity" EXACT [GOC:TermGenie] synonym: "downregulation of thiol peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of TPx activity" EXACT [GOC:TermGenie] synonym: "downregulation of TrxPx activity" EXACT [GOC:TermGenie] synonym: "inhibition of thiol peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of thioredoxin peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of TPx activity" NARROW [GOC:TermGenie] synonym: "inhibition of TrxPx activity" NARROW [GOC:TermGenie] synonym: "negative regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of TPx activity" EXACT [GOC:TermGenie] synonym: "negative regulation of TrxPx activity" EXACT [GOC:TermGenie] is_a: GO:1903123 ! regulation of thioredoxin peroxidase activity is_a: GO:2000469 ! negative regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity relationship: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity created_by: bf creation_date: 2014-06-18T11:03:26Z [Term] id: GO:1903125 name: negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation namespace: biological_process def: "A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity." [GO_REF:0000063, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687] synonym: "negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] synonym: "negative regulation of TPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] synonym: "negative regulation of TrxPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:1903124 ! negative regulation of thioredoxin peroxidase activity intersection_of: GO:0018107 ! peptidyl-threonine phosphorylation intersection_of: negatively_regulates GO:0008379 ! thioredoxin peroxidase activity created_by: bf creation_date: 2014-06-24T08:47:25Z [Term] id: GO:1903126 name: negative regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434] synonym: "down regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] synonym: "down-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] synonym: "downregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] synonym: "inhibition of centriole-centriole cohesion" NARROW [GOC:TermGenie] is_a: GO:0030997 ! regulation of centriole-centriole cohesion is_a: GO:0046606 ! negative regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010457 ! centriole-centriole cohesion relationship: negatively_regulates GO:0010457 ! centriole-centriole cohesion created_by: als creation_date: 2014-06-24T09:31:45Z [Term] id: GO:1903127 name: positive regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434] synonym: "activation of centriole-centriole cohesion" NARROW [GOC:TermGenie] synonym: "up regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] synonym: "up-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] synonym: "upregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] is_a: GO:0030997 ! regulation of centriole-centriole cohesion is_a: GO:0046607 ! positive regulation of centrosome cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010457 ! centriole-centriole cohesion relationship: positively_regulates GO:0010457 ! centriole-centriole cohesion created_by: als creation_date: 2014-06-24T09:31:51Z [Term] id: GO:1903131 name: mononuclear cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] is_a: GO:0002521 ! leukocyte differentiation created_by: cynthia.smith creation_date: 2014-06-25T15:47:09Z [Term] id: GO:1903132 name: regulation of tube lumen cavitation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060605 ! tube lumen cavitation relationship: regulates GO:0060605 ! tube lumen cavitation created_by: dph creation_date: 2014-06-25T20:18:58Z [Term] id: GO:1903133 name: negative regulation of tube lumen cavitation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778] synonym: "inhibition of tube lumen cavitation" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903132 ! regulation of tube lumen cavitation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060605 ! tube lumen cavitation relationship: negatively_regulates GO:0060605 ! tube lumen cavitation created_by: dph creation_date: 2014-06-25T20:19:04Z [Term] id: GO:1903134 name: trehalose catabolic process involved in cellular response to stress namespace: biological_process def: "Any trehalose catabolic process that is involved in cellular response to stress." [GO_REF:0000060, GOC:TermGenie, PMID:15965643] synonym: "mycose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "mycose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "mykose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "mykose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "trehalose breakdown involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "trehalose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] synonym: "trehalose degradation involved in cellular response to stress" EXACT [GOC:TermGenie] is_a: GO:0005993 ! trehalose catabolic process is_a: GO:0070413 ! trehalose metabolism in response to stress intersection_of: GO:0005993 ! trehalose catabolic process intersection_of: part_of GO:0033554 ! cellular response to stress relationship: part_of GO:0010353 ! response to trehalose created_by: al creation_date: 2014-06-25T22:28:34Z [Term] id: GO:1903135 name: cupric ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with cupric ion, copper(2+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322] synonym: "copper(2+)binding" EXACT [CHEBI:29036] synonym: "Cu(2+) binding" EXACT [CHEBI:29036] synonym: "Cu(II) binding" EXACT [PMID:24567322] is_a: GO:0005507 ! copper ion binding created_by: bf creation_date: 2014-06-26T14:38:16Z [Term] id: GO:1903136 name: cuprous ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with cuprous ion, copper(1+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322] synonym: "copper(1+) binding" EXACT [CHEBI:49552] synonym: "Cu(+) binding" EXACT [CHEBI:49552] synonym: "Cu(I) binding" EXACT [PMID:24567322] is_a: GO:0005507 ! copper ion binding created_by: bf creation_date: 2014-06-26T14:38:23Z [Term] id: GO:1903137 name: regulation of MAPK cascade involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] synonym: "regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of Slt2 cascade" NARROW [GOC:TermGenie] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000196 ! cell wall integrity MAPK cascade relationship: regulates GO:0000196 ! cell wall integrity MAPK cascade created_by: mah creation_date: 2014-07-01T10:21:53Z [Term] id: GO:1903138 name: negative regulation of MAPK cascade involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] synonym: "down regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "down regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "down regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "down regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "downregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "downregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "downregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "downregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "inhibition of cell integrity MAPK pathway" NARROW [GOC:TermGenie] synonym: "inhibition of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "inhibition of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "inhibition of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of Slt2 cascade" NARROW [GOC:TermGenie] is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade is_a: GO:1903137 ! regulation of MAPK cascade involved in cell wall organization or biogenesis is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000196 ! cell wall integrity MAPK cascade relationship: negatively_regulates GO:0000196 ! cell wall integrity MAPK cascade created_by: mah creation_date: 2014-07-01T10:21:59Z [Term] id: GO:1903139 name: positive regulation of MAPK cascade involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] synonym: "activation of cell integrity MAPK pathway" NARROW [GOC:TermGenie] synonym: "activation of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie] synonym: "activation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "activation of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "activation of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "activation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "activation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "activation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "positive regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "up regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "up regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "up regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "up regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of Slt2 cascade" NARROW [GOC:TermGenie] synonym: "upregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] synonym: "upregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Mpk1 cascade" NARROW [GOC:TermGenie] synonym: "upregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] synonym: "upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] synonym: "upregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of Slt2 cascade" NARROW [GOC:TermGenie] is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade is_a: GO:1903137 ! regulation of MAPK cascade involved in cell wall organization or biogenesis is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000196 ! cell wall integrity MAPK cascade relationship: positively_regulates GO:0000196 ! cell wall integrity MAPK cascade created_by: mah creation_date: 2014-07-01T10:22:05Z [Term] id: GO:1903140 name: regulation of establishment of endothelial barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061028 ! establishment of endothelial barrier relationship: regulates GO:0061028 ! establishment of endothelial barrier created_by: als creation_date: 2014-07-01T12:12:34Z [Term] id: GO:1903141 name: negative regulation of establishment of endothelial barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] synonym: "down regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of endothelial barrier" NARROW [GOC:TermGenie] is_a: GO:1901551 ! negative regulation of endothelial cell development is_a: GO:1903140 ! regulation of establishment of endothelial barrier intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061028 ! establishment of endothelial barrier relationship: negatively_regulates GO:0061028 ! establishment of endothelial barrier created_by: als creation_date: 2014-07-01T12:12:40Z [Term] id: GO:1903142 name: positive regulation of establishment of endothelial barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] synonym: "activation of establishment of endothelial barrier" NARROW [GOC:TermGenie] synonym: "up regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] is_a: GO:1901552 ! positive regulation of endothelial cell development is_a: GO:1903140 ! regulation of establishment of endothelial barrier intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061028 ! establishment of endothelial barrier relationship: positively_regulates GO:0061028 ! establishment of endothelial barrier created_by: als creation_date: 2014-07-01T12:12:52Z [Term] id: GO:1903143 name: adrenomedullin receptor complex namespace: cellular_component def: "A transmembrane, G protein-coupled signalling receptor complex which is capable of adrenomedullin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369] comment: An example of this is RAMP2 in human (O60895) in PMID:22102369 (inferred from direct assay). synonym: "adrenomedullin receptor AM1 complex" NARROW [] synonym: "adrenomedullin receptor AM2 complex" NARROW [] is_a: GO:0038037 ! G protein-coupled receptor dimeric complex is_a: GO:1903439 ! calcitonin family receptor complex created_by: bhm creation_date: 2014-07-02T08:56:47Z [Term] id: GO:1903144 name: actomyosin contractile ring actin filament namespace: cellular_component def: "Any actin filament that is part of a actomyosin contractile ring." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052] synonym: "actin filament of actomyosin contractile ring" EXACT [GOC:TermGenie] synonym: "actin filament of actomyosin ring" EXACT [GOC:TermGenie] synonym: "actin filament of CAR" EXACT [GOC:TermGenie] synonym: "actin filament of contractile actomyosin ring" EXACT [GOC:TermGenie] synonym: "actin filament of cytokinetic ring" EXACT [GOC:TermGenie] is_a: GO:0005884 ! actin filament intersection_of: GO:0005884 ! actin filament intersection_of: part_of GO:0005826 ! actomyosin contractile ring relationship: part_of GO:0005826 ! actomyosin contractile ring created_by: vw creation_date: 2014-07-06T16:20:05Z [Term] id: GO:1903145 name: actin filament of cell cortex of cell tip namespace: cellular_component def: "Any actin filament that is part of a cell cortex of cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052] synonym: "actin filament of cell cortex of cell end" EXACT [GOC:TermGenie] synonym: "microfilament of cell cortex of cell end" EXACT [GOC:TermGenie] synonym: "microfilament of cell cortex of cell tip" EXACT [GOC:TermGenie] is_a: GO:0005884 ! actin filament intersection_of: GO:0005884 ! actin filament intersection_of: part_of GO:0051285 ! cell cortex of cell tip relationship: part_of GO:0051285 ! cell cortex of cell tip created_by: vw creation_date: 2014-07-06T16:24:01Z [Term] id: GO:1903146 name: regulation of autophagy of mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] synonym: "regulation of mitochondrion degradation" BROAD [GOC:TermGenie] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000422 ! autophagy of mitochondrion relationship: regulates GO:0000422 ! autophagy of mitochondrion created_by: bf creation_date: 2014-07-09T08:23:51Z [Term] id: GO:1903147 name: negative regulation of autophagy of mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] synonym: "down regulation of mitochondrial degradation" BROAD [GOC:TermGenie] synonym: "down regulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "down-regulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "down-regulation of mitophagy" BROAD [GOC:TermGenie] synonym: "downregulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "inhibition of mitochondrion degradation" RELATED [GOC:TermGenie] synonym: "inhibition of mitophagy" NARROW [GOC:TermGenie] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:1903146 ! regulation of autophagy of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000422 ! autophagy of mitochondrion relationship: negatively_regulates GO:0000422 ! autophagy of mitochondrion created_by: bf creation_date: 2014-07-09T08:23:58Z [Term] id: GO:1903148 name: obsolete uracil transmembrane transporter activity involved in uracil import into cell namespace: molecular_function def: "OBSOLETE. Any uracil transmembrane transporter activity that is involved in uracil import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "uracil transmembrane transporter activity involved in uracil import into cell" EXACT [] synonym: "uracil/uridine permease activity involved in uracil import into cell" RELATED [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:24Z [Term] id: GO:1903149 name: obsolete adenine transmembrane transporter activity involved in adenine import into cell namespace: molecular_function def: "OBSOLETE. Any adenine transmembrane transporter activity that is involved in adenine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "adenine transmembrane transporter activity involved in adenine import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:30Z [Term] id: GO:1903150 name: obsolete calcium ion transmembrane transporter activity involved in calcium ion import into cell namespace: molecular_function def: "OBSOLETE. Any calcium ion transmembrane transporter activity that is involved in calcium ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "calcium ion transmembrane transporter activity involved in calcium ion import into cell" EXACT [] synonym: "calcium ion transmembrane transporter activity involved in calcium ion uptake into cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:36Z [Term] id: GO:1903151 name: obsolete carbohydrate transmembrane transporter activity involved in carbohydrate import into cell namespace: molecular_function def: "OBSOLETE. Any carbohydrate transmembrane transporter activity that is involved in carbohydrate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "carbohydrate transmembrane transporter activity involved in carbohydrate import into cell" EXACT [] synonym: "sugar transporter involved in carbohydrate import into cell" NARROW [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:42Z [Term] id: GO:1903152 name: obsolete copper ion transmembrane transporter activity involved in copper ion import into cell namespace: molecular_function def: "OBSOLETE. Any copper ion transmembrane transporter activity that is involved in copper ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "copper ion transmembrane transporter activity involved in copper cation import into cell" EXACT [GOC:TermGenie] synonym: "copper ion transmembrane transporter activity involved in copper ion import into cell" EXACT [] synonym: "intracellular copper ion transporter involved in copper cation import into cell" NARROW [GOC:TermGenie] synonym: "intracellular copper ion transporter involved in copper ion import into cell" NARROW [GOC:TermGenie] synonym: "plasma membrane copper transporter involved in copper cation import into cell" NARROW [GOC:TermGenie] synonym: "plasma membrane copper transporter involved in copper ion import into cell" NARROW [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:47Z [Term] id: GO:1903153 name: obsolete ferrous iron transmembrane transporter activity involved in ferrous iron import into cell namespace: molecular_function def: "OBSOLETE. Any ferrous iron transmembrane transporter activity that is involved in ferrous iron import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "ferrous iron transmembrane transporter activity involved in ferrous ion import into cell" EXACT [GOC:TermGenie] synonym: "ferrous iron transmembrane transporter activity involved in ferrous iron import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:53Z [Term] id: GO:1903154 name: obsolete glucose transmembrane transporter activity involved in glucose import into cell namespace: molecular_function def: "OBSOLETE. Any glucose transmembrane transporter activity that is involved in glucose import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "galactose/glucose (methylgalactoside) porter activity involved in glucose import into cell" RELATED [GOC:TermGenie] synonym: "glucose permease activity involved in glucose import into cell" EXACT [GOC:TermGenie] synonym: "glucose transmembrane transporter activity involved in glucose import into cell" EXACT [] synonym: "lactose/glucose efflux transporter activity involved in glucose import into cell" NARROW [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:55:59Z [Term] id: GO:1903155 name: obsolete glutathione transmembrane transporter activity involved in glutathione import into cell namespace: molecular_function def: "OBSOLETE. Any glutathione transmembrane transporter activity that is involved in glutathione import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "glutathione transmembrane transporter activity involved in glutathione import into cell" EXACT [] synonym: "glutathione transmembrane transporter activity involved in glutathione uptake" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:05Z [Term] id: GO:1903156 name: obsolete guanine transmembrane transporter activity involved in guanine import into cell namespace: molecular_function def: "OBSOLETE. Any guanine transmembrane transporter activity that is involved in guanine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "guanine transmembrane transporter activity involved in guanine import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:10Z [Term] id: GO:1903157 name: obsolete iron ion transmembrane transporter activity involved in iron ion import into cell namespace: molecular_function def: "OBSOLETE. Any iron ion transmembrane transporter activity that is involved in iron ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "iron ion transmembrane transporter activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "iron ion transmembrane transporter activity involved in iron ion import into cell" EXACT [] synonym: "iron transporter activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "iron transporter activity involved in iron ion import into cell" EXACT [GOC:TermGenie] synonym: "multicopper ferroxidase iron transport mediator activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "multicopper ferroxidase iron transport mediator activity involved in iron ion import into cell" RELATED [GOC:TermGenie] synonym: "transmembrane iron ion permease activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "transmembrane iron ion permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie] synonym: "transmembrane iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "transmembrane iron permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie] synonym: "zinc, iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie] synonym: "zinc, iron permease activity involved in iron ion import into cell" RELATED [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:16Z [Term] id: GO:1903158 name: obsolete L-glutamate transmembrane transporter activity involved in L-glutamate import into cell namespace: molecular_function def: "OBSOLETE. Any L-glutamate transmembrane transporter activity that is involved in L-glutamate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "glutamate/aspartate porter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie] synonym: "glutamate/aspartate:sodium symporter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie] synonym: "L-glutamate transmembrane transporter activity involved in L-glutamate import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:21Z [Term] id: GO:1903159 name: obsolete malate transmembrane transporter activity involved in malate import into cell namespace: molecular_function def: "OBSOLETE. Any malate transmembrane transporter activity that is involved in malate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in malate import into cell" RELATED [GOC:TermGenie] synonym: "malate transmembrane transporter activity involved in malate import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:27Z [Term] id: GO:1903160 name: obsolete nickel cation transmembrane transporter activity involved in nickel cation import into cell namespace: molecular_function def: "OBSOLETE. Any nickel cation transmembrane transporter activity that is involved in nickel cation import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "nickel cation transmembrane transporter activity involved in nickel cation import into cell" EXACT [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity involved in nickel cation import into cell" RELATED [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:33Z [Term] id: GO:1903161 name: obsolete pantothenate transmembrane transporter activity involved in pantothenate import into cell namespace: molecular_function def: "OBSOLETE. Any pantothenate transmembrane transporter activity that is involved in pantothenate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "pantothenate transmembrane transporter activity involved in pantothenate import into cell" EXACT [] synonym: "vitamin B5 transmembrane transporter activity involved in pantothenate import into cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:38Z [Term] id: GO:1903162 name: obsolete serine transmembrane transporter activity involved in serine import into cell namespace: molecular_function def: "OBSOLETE. Any serine transmembrane transporter activity that is involved in serine import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "serine transmembrane transporter activity involved in serine import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:44Z [Term] id: GO:1903163 name: obsolete sodium ion transmembrane transporter activity involved in sodium ion import into cell namespace: molecular_function def: "OBSOLETE. Any sodium ion transmembrane transporter activity that is involved in sodium ion import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "sodium ion transmembrane transporter activity involved in sodium ion import into cell" EXACT [] synonym: "sodium transporter activity involved in sodium ion import into cell" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:49Z [Term] id: GO:1903164 name: obsolete succinate transmembrane transporter activity involved in succinate import into cell namespace: molecular_function def: "OBSOLETE. Any succinate transmembrane transporter activity that is involved in succinate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in succinate import into cell" RELATED [GOC:TermGenie] synonym: "succinate transmembrane transporter activity involved in succinate import into cell" EXACT [] is_obsolete: true created_by: dos creation_date: 2014-07-09T11:56:55Z [Term] id: GO:1903165 name: response to polycyclic arene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug created_by: mr creation_date: 2014-07-09T18:32:59Z [Term] id: GO:1903166 name: cellular response to polycyclic arene namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1903165 ! response to polycyclic arene created_by: mr creation_date: 2014-07-09T18:33:04Z [Term] id: GO:1903167 name: regulation of pyrroline-5-carboxylate reductase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of P5CR activity" EXACT [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity relationship: regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity created_by: bf creation_date: 2014-07-09T19:51:19Z [Term] id: GO:1903168 name: positive regulation of pyrroline-5-carboxylate reductase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23743200] synonym: "activation of 1-pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of L-proline oxidase activity" NARROW [GOC:TermGenie] synonym: "activation of L-proline-NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of L-proline:NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" NARROW [GOC:TermGenie] synonym: "activation of P5CR activity" NARROW [GOC:TermGenie] synonym: "activation of pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of P5CR activity" EXACT [GOC:TermGenie] synonym: "up regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of P5CR activity" EXACT [GOC:TermGenie] synonym: "up regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of P5CR activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-proline oxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of P5CR activity" EXACT [GOC:TermGenie] synonym: "upregulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1903167 ! regulation of pyrroline-5-carboxylate reductase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity relationship: positively_regulates GO:0004735 ! pyrroline-5-carboxylate reductase activity created_by: bf creation_date: 2014-07-09T19:51:25Z [Term] id: GO:1903169 name: regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol synonym: "regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051924 ! regulation of calcium ion transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070588 ! calcium ion transmembrane transport relationship: regulates GO:0070588 ! calcium ion transmembrane transport created_by: rl creation_date: 2014-07-11T17:09:26Z [Term] id: GO:1903170 name: negative regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol synonym: "down regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of calcium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of transmembrane calcium transport" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "negative regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051926 ! negative regulation of calcium ion transport is_a: GO:1903169 ! regulation of calcium ion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070588 ! calcium ion transmembrane transport relationship: negatively_regulates GO:0070588 ! calcium ion transmembrane transport created_by: rl creation_date: 2014-07-11T17:09:32Z [Term] id: GO:1903171 name: carbon dioxide homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594] is_a: GO:0048878 ! chemical homeostasis created_by: mr creation_date: 2014-07-11T20:58:24Z [Term] id: GO:1903172 name: cellular carbon dioxide homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594] is_a: GO:0055082 ! cellular chemical homeostasis is_a: GO:1903171 ! carbon dioxide homeostasis created_by: mr creation_date: 2014-07-11T20:58:30Z [Term] id: GO:1903173 name: fatty alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] synonym: "fatty alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006629 ! lipid metabolic process created_by: tt creation_date: 2014-07-14T01:51:41Z [Term] id: GO:1903174 name: fatty alcohol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] synonym: "fatty alcohol breakdown" EXACT [GOC:TermGenie] synonym: "fatty alcohol catabolism" EXACT [GOC:TermGenie] synonym: "fatty alcohol degradation" EXACT [GOC:TermGenie] is_a: GO:0016042 ! lipid catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1903173 ! fatty alcohol metabolic process created_by: tt creation_date: 2014-07-14T01:51:48Z [Term] id: GO:1903175 name: fatty alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] synonym: "fatty alcohol anabolism" EXACT [GOC:TermGenie] synonym: "fatty alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "fatty alcohol formation" EXACT [GOC:TermGenie] synonym: "fatty alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1903173 ! fatty alcohol metabolic process created_by: tt creation_date: 2014-07-14T01:51:54Z [Term] id: GO:1903176 name: regulation of tyrosine 3-monooxygenase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] is_a: GO:0032768 ! regulation of monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004511 ! tyrosine 3-monooxygenase activity relationship: regulates GO:0004511 ! tyrosine 3-monooxygenase activity created_by: bf creation_date: 2014-07-14T10:39:09Z [Term] id: GO:1903177 name: negative regulation of tyrosine 3-monooxygenase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "down regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "down-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "downregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "inhibition of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine hydroxylase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "negative regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity relationship: negatively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity created_by: bf creation_date: 2014-07-14T10:39:15Z [Term] id: GO:1903178 name: positive regulation of tyrosine 3-monooxygenase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] synonym: "activation of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie] synonym: "activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie] synonym: "activation of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie] synonym: "activation of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie] synonym: "activation of tyrosine hydroxylase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "positive regulation of TH activity" EXACT [PMID:19703902] synonym: "positive regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "stimulation of TH activity" EXACT [PMID:19703902] synonym: "up regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "up regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "up-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] synonym: "upregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity relationship: positively_regulates GO:0004511 ! tyrosine 3-monooxygenase activity created_by: bf creation_date: 2014-07-14T10:39:21Z [Term] id: GO:1903179 name: regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042053 ! regulation of dopamine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042416 ! dopamine biosynthetic process relationship: regulates GO:0042416 ! dopamine biosynthetic process created_by: bf creation_date: 2014-07-14T12:17:41Z [Term] id: GO:1903180 name: negative regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045963 ! negative regulation of dopamine metabolic process is_a: GO:1903179 ! regulation of dopamine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042416 ! dopamine biosynthetic process relationship: negatively_regulates GO:0042416 ! dopamine biosynthetic process created_by: bf creation_date: 2014-07-14T12:17:47Z [Term] id: GO:1903181 name: positive regulation of dopamine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie] synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of dopamine formation" NARROW [GOC:TermGenie] synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045964 ! positive regulation of dopamine metabolic process is_a: GO:1903179 ! regulation of dopamine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042416 ! dopamine biosynthetic process relationship: positively_regulates GO:0042416 ! dopamine biosynthetic process created_by: bf creation_date: 2014-07-14T12:17:53Z [Term] id: GO:1903182 name: regulation of SUMO transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] synonym: "regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] is_a: GO:0033233 ! regulation of protein sumoylation is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019789 ! SUMO transferase activity relationship: regulates GO:0019789 ! SUMO transferase activity created_by: bf creation_date: 2014-07-14T14:01:40Z [Term] id: GO:1903183 name: negative regulation of SUMO transferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528] synonym: "down regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] synonym: "down regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] synonym: "down regulation of SUMO ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] synonym: "down-regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] synonym: "down-regulation of SUMO ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] synonym: "downregulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] synonym: "downregulation of SUMO ligase activity" EXACT [GOC:TermGenie] synonym: "inhibition of SMT3 conjugating enzyme" NARROW [GOC:TermGenie] synonym: "inhibition of SUMO conjugating enzyme activity" NARROW [GOC:TermGenie] synonym: "inhibition of SUMO ligase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] synonym: "negative regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] is_a: GO:0033234 ! negative regulation of protein sumoylation is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1903182 ! regulation of SUMO transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019789 ! SUMO transferase activity relationship: negatively_regulates GO:0019789 ! SUMO transferase activity created_by: bf creation_date: 2014-07-14T14:01:46Z [Term] id: GO:1903184 name: L-dopa metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146] synonym: "L-dopa metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: bf creation_date: 2014-07-14T15:06:00Z [Term] id: GO:1903185 name: L-dopa biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146] synonym: "L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "L-dopa formation" EXACT [GOC:TermGenie] synonym: "L-dopa synthesis" EXACT [GOC:TermGenie] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process is_a: GO:1903184 ! L-dopa metabolic process created_by: bf creation_date: 2014-07-14T15:06:06Z [Term] id: GO:1903186 name: regulation of vitellogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] synonym: "regulation of yolk production" EXACT [GOC:TermGenie] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007296 ! vitellogenesis relationship: regulates GO:0007296 ! vitellogenesis created_by: mr creation_date: 2014-07-14T19:28:00Z [Term] id: GO:1903187 name: negative regulation of vitellogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] synonym: "down regulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of yolk production" EXACT [GOC:TermGenie] synonym: "down-regulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of yolk production" EXACT [GOC:TermGenie] synonym: "downregulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of yolk production" EXACT [GOC:TermGenie] synonym: "inhibition of vitellogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of yolk production" NARROW [GOC:TermGenie] synonym: "negative regulation of yolk production" EXACT [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903186 ! regulation of vitellogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007296 ! vitellogenesis relationship: negatively_regulates GO:0007296 ! vitellogenesis created_by: mr creation_date: 2014-07-14T19:28:06Z [Term] id: GO:1903188 name: positive regulation of vitellogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] synonym: "activation of vitellogenesis" NARROW [GOC:TermGenie] synonym: "activation of yolk production" NARROW [GOC:TermGenie] synonym: "positive regulation of yolk production" EXACT [GOC:TermGenie] synonym: "up regulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of yolk production" EXACT [GOC:TermGenie] synonym: "up-regulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of yolk production" EXACT [GOC:TermGenie] synonym: "upregulation of vitellogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of yolk production" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903186 ! regulation of vitellogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007296 ! vitellogenesis relationship: positively_regulates GO:0007296 ! vitellogenesis created_by: mr creation_date: 2014-07-14T19:28:12Z [Term] id: GO:1903189 name: glyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "glyoxal metabolism" EXACT [GOC:TermGenie] is_a: GO:0006081 ! cellular aldehyde metabolic process created_by: bf creation_date: 2014-07-15T10:11:45Z [Term] id: GO:1903190 name: glyoxal catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22523093, PMID:23651081] synonym: "glyoxal breakdown" EXACT [GOC:TermGenie] synonym: "glyoxal catabolism" EXACT [GOC:TermGenie] synonym: "glyoxal degradation" EXACT [GOC:TermGenie] is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:1903189 ! glyoxal metabolic process created_by: bf creation_date: 2014-07-15T10:11:51Z [Term] id: GO:1903191 name: glyoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "glyoxal anabolism" EXACT [GOC:TermGenie] synonym: "glyoxal biosynthesis" EXACT [GOC:TermGenie] synonym: "glyoxal formation" EXACT [GOC:TermGenie] synonym: "glyoxal synthesis" EXACT [GOC:TermGenie] is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:1903189 ! glyoxal metabolic process created_by: bf creation_date: 2014-07-15T10:11:57Z [Term] id: GO:1903192 name: sesquarterpene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333] synonym: "sesquarterpene metabolism" EXACT [GOC:TermGenie] is_a: GO:0042214 ! terpene metabolic process created_by: tt creation_date: 2014-07-16T17:04:47Z [Term] id: GO:1903193 name: sesquarterpene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333] synonym: "sesquarterpene anabolism" EXACT [GOC:TermGenie] synonym: "sesquarterpene biosynthesis" EXACT [GOC:TermGenie] synonym: "sesquarterpene formation" EXACT [GOC:TermGenie] synonym: "sesquarterpene synthesis" EXACT [GOC:TermGenie] is_a: GO:0046246 ! terpene biosynthetic process is_a: GO:1903192 ! sesquarterpene metabolic process created_by: tt creation_date: 2014-07-16T17:04:53Z [Term] id: GO:1903195 name: regulation of L-dopa biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "regulation of L-dopa synthesis" EXACT [GOC:TermGenie] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903185 ! L-dopa biosynthetic process relationship: regulates GO:1903185 ! L-dopa biosynthetic process created_by: bf creation_date: 2014-07-21T09:12:37Z [Term] id: GO:1903196 name: negative regulation of L-dopa biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "down regulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of L-dopa anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of L-dopa biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of L-dopa biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of L-dopa formation" NARROW [GOC:TermGenie] synonym: "inhibition of L-dopa synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "negative regulation of L-dopa synthesis" EXACT [GOC:TermGenie] is_a: GO:1903195 ! regulation of L-dopa biosynthetic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903185 ! L-dopa biosynthetic process relationship: negatively_regulates GO:1903185 ! L-dopa biosynthetic process created_by: bf creation_date: 2014-07-21T09:12:44Z [Term] id: GO:1903197 name: positive regulation of L-dopa biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528] synonym: "activation of L-dopa anabolism" NARROW [GOC:TermGenie] synonym: "activation of L-dopa biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of L-dopa biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of L-dopa formation" NARROW [GOC:TermGenie] synonym: "activation of L-dopa synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "positive regulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa formation" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa synthesis" EXACT [GOC:TermGenie] is_a: GO:1903195 ! regulation of L-dopa biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903185 ! L-dopa biosynthetic process relationship: positively_regulates GO:1903185 ! L-dopa biosynthetic process created_by: bf creation_date: 2014-07-21T09:12:49Z [Term] id: GO:1903198 name: regulation of L-dopa decarboxylase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036468 ! L-dopa decarboxylase activity relationship: regulates GO:0036468 ! L-dopa decarboxylase activity created_by: bf creation_date: 2014-07-21T09:32:31Z [Term] id: GO:1903199 name: negative regulation of L-dopa decarboxylase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "down regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DDC activity" EXACT [GOC:TermGenie] synonym: "downregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DDC activity" NARROW [GOC:TermGenie] synonym: "inhibition of DOPA decarboxylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of L-dopa decarboxylase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] is_a: GO:0051350 ! negative regulation of lyase activity is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036468 ! L-dopa decarboxylase activity relationship: negatively_regulates GO:0036468 ! L-dopa decarboxylase activity created_by: bf creation_date: 2014-07-21T09:32:37Z [Term] id: GO:1903200 name: positive regulation of L-dopa decarboxylase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] synonym: "activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie] synonym: "activation of DDC activity" NARROW [GOC:TermGenie] synonym: "activation of DOPA decarboxylase activity" NARROW [GOC:TermGenie] synonym: "activation of L-dopa decarboxylase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "up regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DDC activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DDC activity" EXACT [GOC:TermGenie] synonym: "upregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] is_a: GO:0051349 ! positive regulation of lyase activity is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036468 ! L-dopa decarboxylase activity relationship: positively_regulates GO:0036468 ! L-dopa decarboxylase activity created_by: bf creation_date: 2014-07-21T09:32:43Z [Term] id: GO:1903201 name: regulation of oxidative stress-induced cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of cell death in response to oxidative stress" EXACT [GOC:bf] is_a: GO:0010941 ! regulation of cell death is_a: GO:1900407 ! regulation of cellular response to oxidative stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036473 ! cell death in response to oxidative stress relationship: regulates GO:0036473 ! cell death in response to oxidative stress created_by: bf creation_date: 2014-07-21T16:10:30Z [Term] id: GO:1903202 name: negative regulation of oxidative stress-induced cell death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of cell death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of cell death in response to oxidative stress" EXACT [GOC:bf] synonym: "protection against oxidative stress-induced cell death" RELATED [GOC:bf] is_a: GO:0060548 ! negative regulation of cell death is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress is_a: GO:1903201 ! regulation of oxidative stress-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036473 ! cell death in response to oxidative stress relationship: negatively_regulates GO:0036473 ! cell death in response to oxidative stress created_by: bf creation_date: 2014-07-21T16:10:36Z [Term] id: GO:1903203 name: regulation of oxidative stress-induced neuron death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of neuron death in response to oxidative stress" EXACT [GOC:bf] synonym: "regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:1901214 ! regulation of neuron death is_a: GO:1903201 ! regulation of oxidative stress-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036475 ! neuron death in response to oxidative stress relationship: regulates GO:0036475 ! neuron death in response to oxidative stress created_by: bf creation_date: 2014-07-21T16:17:30Z [Term] id: GO:1903204 name: negative regulation of oxidative stress-induced neuron death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] synonym: "downregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] synonym: "inhibition of neuron death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "inhibition of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "inhibition of oxidative stress-induced neuron death" NARROW [GOC:TermGenie] synonym: "negative regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "neuronal protection under oxidative stress" RELATED [GOC:bf] synonym: "neuroprotection against oxidative stress" RELATED [GOC:bf] is_a: GO:1901215 ! negative regulation of neuron death is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036475 ! neuron death in response to oxidative stress relationship: negatively_regulates GO:0036475 ! neuron death in response to oxidative stress created_by: bf creation_date: 2014-07-21T16:17:36Z [Term] id: GO:1903205 name: regulation of hydrogen peroxide-induced cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "protection against hydrogen peroxide-mediated cell death" RELATED [GOC:bf] synonym: "regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf] synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1903201 ! regulation of oxidative stress-induced cell death is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: regulates GO:0036474 ! cell death in response to hydrogen peroxide created_by: bf creation_date: 2014-07-21T16:21:47Z [Term] id: GO:1903206 name: negative regulation of hydrogen peroxide-induced cell death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804] synonym: "down regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "down regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "down-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "down-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "downregulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "downregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "inhibition of cell death in response to H2O2" NARROW [GOC:TermGenie] synonym: "inhibition of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "negative regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "negative regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf] synonym: "negative regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "protection against H2O2-induced cell death" RELATED [GOC:bf] synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC:bf] is_a: GO:1901032 ! negative regulation of response to reactive oxygen species is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death is_a: GO:2001039 ! negative regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide created_by: bf creation_date: 2014-07-21T16:21:53Z [Term] id: GO:1903207 name: regulation of hydrogen peroxide-induced neuron death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] synonym: "regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf] synonym: "regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036476 ! neuron death in response to hydrogen peroxide relationship: regulates GO:0036476 ! neuron death in response to hydrogen peroxide created_by: bf creation_date: 2014-07-21T16:27:05Z [Term] id: GO:1903208 name: negative regulation of hydrogen peroxide-induced neuron death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] synonym: "down regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] synonym: "down regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down-regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] synonym: "downregulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] synonym: "downregulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "downregulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "inhibition of hydrogen peroxide-induced neuron death" NARROW [GOC:TermGenie] synonym: "inhibition of neuron death in response to H2O2" NARROW [GOC:TermGenie] synonym: "inhibition of neuron death in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "inhibition of neuronal cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "negative regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] synonym: "negative regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf] synonym: "negative regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "neuroprotection against H2O2-induced cell death" RELATED [GOC:bf] synonym: "neuroprotection against hydrogen peroxide" RELATED [GOC:bf] synonym: "protection against H2O2-induced neuron death" RELATED [GOC:bf] synonym: "protection against hydrogen peroxide-induced neuron death" RELATED [GOC:bf] is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036476 ! neuron death in response to hydrogen peroxide relationship: negatively_regulates GO:0036476 ! neuron death in response to hydrogen peroxide created_by: bf creation_date: 2014-07-21T16:27:11Z [Term] id: GO:1903209 name: positive regulation of oxidative stress-induced cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20969476] synonym: "activation of cell death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "enhancement of oxidative stress-induced cell death" NARROW [] synonym: "positive regulation of cell death in response to oxidative stress" EXACT [] synonym: "up regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0010942 ! positive regulation of cell death is_a: GO:1900409 ! positive regulation of cellular response to oxidative stress is_a: GO:1903201 ! regulation of oxidative stress-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036473 ! cell death in response to oxidative stress relationship: positively_regulates GO:0036473 ! cell death in response to oxidative stress created_by: bf creation_date: 2014-07-22T09:32:19Z [Term] id: GO:1903210 name: glomerular visceral epithelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in a glomerular visceral epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:23515840] synonym: "glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "podocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2014-07-23T17:07:55Z [Term] id: GO:1903211 name: mitotic recombination involved in replication fork processing namespace: biological_process def: "Any mitotic recombination that is involved in replication fork processing." [GO_REF:0000060, GOC:mah, GOC:TermGenie, PMID:23093942] synonym: "mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie] synonym: "mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie] synonym: "mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie] synonym: "mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie] synonym: "mitotic recombination involved in replication restart" RELATED [GOC:TermGenie] is_a: GO:0006312 ! mitotic recombination is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006312 ! mitotic recombination intersection_of: part_of GO:1990426 ! mitotic recombination-dependent replication fork processing relationship: part_of GO:1990426 ! mitotic recombination-dependent replication fork processing created_by: mah creation_date: 2014-07-24T09:33:40Z [Term] id: GO:1903212 name: protein localization to mating-type region heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:18761674] synonym: "protein localisation in mating-type region heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to mating-type region heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in mating-type region heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0097355 ! protein localization to heterochromatin created_by: mah creation_date: 2014-07-24T09:38:12Z [Term] id: GO:1903213 name: protein localization to subtelomeric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin." [GO_REF:0000087, GOC:TermGenie, SO:0001997] synonym: "protein localisation in subtelomeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to subtelomeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in subtelomeric heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0097355 ! protein localization to heterochromatin created_by: mah creation_date: 2014-07-24T09:38:18Z [Term] id: GO:1903214 name: regulation of protein targeting to mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:1903533 ! regulation of protein targeting is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006626 ! protein targeting to mitochondrion relationship: regulates GO:0006626 ! protein targeting to mitochondrion created_by: bf creation_date: 2014-07-24T10:17:13Z [Term] id: GO:1903215 name: negative regulation of protein targeting to mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] synonym: "down regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "down regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "down regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "down-regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "downregulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "downregulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "inhibition of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "inhibition of protein import into mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to mitochondria" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of protein-mitochondrial targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "negative regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "negative regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1903214 ! regulation of protein targeting to mitochondrion is_a: GO:1903748 ! negative regulation of establishment of protein localization to mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006626 ! protein targeting to mitochondrion relationship: negatively_regulates GO:0006626 ! protein targeting to mitochondrion created_by: bf creation_date: 2014-07-24T10:17:19Z [Term] id: GO:1903216 name: regulation of protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] synonym: "regulation of mitochondrial processing" BROAD [GOC:TermGenie] synonym: "regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903214 ! regulation of protein targeting to mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion relationship: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion created_by: bf creation_date: 2014-07-24T10:20:54Z [Term] id: GO:1903217 name: negative regulation of protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] synonym: "down regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] synonym: "down regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] synonym: "down-regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] synonym: "downregulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial protein processing during import" RELATED [GOC:TermGenie] synonym: "inhibition of protein processing involved in protein targeting to mitochondrion" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] is_a: GO:0010955 ! negative regulation of protein processing is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion is_a: GO:1903216 ! regulation of protein processing involved in protein targeting to mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion relationship: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion created_by: bf creation_date: 2014-07-24T10:21:00Z [Term] id: GO:1903218 name: regulation of malate dehydrogenase (decarboxylating) (NADP+) activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] synonym: "regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity relationship: regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity created_by: sart creation_date: 2014-07-24T11:17:22Z [Term] id: GO:1903219 name: negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] synonym: "down regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "down regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "down regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "down regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "down regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "down regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "down regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "down-regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "down-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "down-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "down-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "down-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "downregulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "downregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "downregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "downregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "downregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "downregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "downregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "inhibition of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie] synonym: "inhibition of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie] synonym: "inhibition of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie] synonym: "inhibition of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie] synonym: "inhibition of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "inhibition of NADP-malic enzyme activity" NARROW [GOC:TermGenie] synonym: "inhibition of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "negative regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "negative regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "negative regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "negative regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "negative regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity relationship: negatively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity created_by: sart creation_date: 2014-07-24T11:17:28Z [Term] id: GO:1903220 name: positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] synonym: "activation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie] synonym: "activation of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie] synonym: "activation of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie] synonym: "activation of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie] synonym: "activation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "activation of NADP-malic enzyme activity" NARROW [GOC:TermGenie] synonym: "activation of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "positive regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "positive regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "positive regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "positive regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "positive regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "up regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "up regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "up regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "up regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "up regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "up regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "up regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "up-regulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "up-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "up-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "up-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "up-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] synonym: "upregulation of 'malic' enzyme" RELATED [GOC:TermGenie] synonym: "upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] synonym: "upregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] synonym: "upregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] synonym: "upregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] synonym: "upregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] synonym: "upregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] synonym: "upregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity relationship: positively_regulates GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity created_by: sart creation_date: 2014-07-24T11:17:34Z [Term] id: GO:1903221 name: regulation of mitotic recombination involved in replication fork processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic recombination involved in replication fork processing. Regulation of mitotic recombination contributes to replication fork processing by preventing recombination between inappropriate homologous sequences." [GO_REF:0000058, GOC:TermGenie, PMID:23093942] synonym: "prevention of genomic instability induced by DNA replication fork arrest" RELATED [PMID:23093942] synonym: "regulation of mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie] synonym: "regulation of mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie] synonym: "regulation of mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie] synonym: "regulation of mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie] synonym: "regulation of mitotic recombination involved in replication restart" RELATED [GOC:TermGenie] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903211 ! mitotic recombination involved in replication fork processing relationship: regulates GO:1903211 ! mitotic recombination involved in replication fork processing created_by: mah creation_date: 2014-07-24T13:30:21Z [Term] id: GO:1903222 name: quinolinic acid transmembrane transport namespace: biological_process def: "The process in which quinolinic acid is transported across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: di creation_date: 2014-07-26T07:29:07Z [Term] id: GO:1903223 name: positive regulation of oxidative stress-induced neuron death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23858059] synonym: "activation of neuron death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "activation of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "activation of oxidative stress-induced neuron death" NARROW [GOC:TermGenie] synonym: "positive regulation of neuron death in response to oxidative stress" EXACT [GOC:bf] synonym: "positive regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "sensitization of neuron to oxidative stress-induced cell death" RELATED [PMID:23858059] synonym: "up regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] synonym: "up-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] synonym: "upregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] is_a: GO:1901216 ! positive regulation of neuron death is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036475 ! neuron death in response to oxidative stress relationship: positively_regulates GO:0036475 ! neuron death in response to oxidative stress created_by: bf creation_date: 2014-07-29T08:51:52Z [Term] id: GO:1903224 name: regulation of endodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035987 ! endodermal cell differentiation relationship: regulates GO:0035987 ! endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:35Z [Term] id: GO:1903225 name: negative regulation of endodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035987 ! endodermal cell differentiation relationship: negatively_regulates GO:0035987 ! endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:41Z [Term] id: GO:1903226 name: positive regulation of endodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035987 ! endodermal cell differentiation relationship: positively_regulates GO:0035987 ! endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:47Z [Term] id: GO:1903227 name: xanthosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] synonym: "xanthosine metabolism" EXACT [GOC:TermGenie] is_a: GO:0046128 ! purine ribonucleoside metabolic process created_by: jl creation_date: 2014-07-31T09:21:46Z [Term] id: GO:1903228 name: xanthosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] synonym: "xanthosine breakdown" EXACT [GOC:TermGenie] synonym: "xanthosine catabolism" EXACT [GOC:TermGenie] synonym: "xanthosine degradation" EXACT [GOC:TermGenie] is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:1903227 ! xanthosine metabolic process created_by: jl creation_date: 2014-07-31T09:21:52Z [Term] id: GO:1903229 name: xanthosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] synonym: "xanthosine anabolism" EXACT [GOC:TermGenie] synonym: "xanthosine biosynthesis" EXACT [GOC:TermGenie] synonym: "xanthosine formation" EXACT [GOC:TermGenie] synonym: "xanthosine synthesis" EXACT [GOC:TermGenie] is_a: GO:0046129 ! purine ribonucleoside biosynthetic process is_a: GO:1903227 ! xanthosine metabolic process created_by: jl creation_date: 2014-07-31T09:21:58Z [Term] id: GO:1903230 name: obsolete miRNA binding involved in posttranscriptional gene silencing namespace: molecular_function def: "OBSOLETE. Any miRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:jl, GOC:TermGenie] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "microRNA binding involved in cosuppression" RELATED [GOC:TermGenie] synonym: "microRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] synonym: "microRNA binding involved in posttranscriptional gene silencing" EXACT [GOC:TermGenie] synonym: "microRNA binding involved in PTGS" EXACT [GOC:TermGenie] synonym: "microRNA binding involved in quelling" EXACT [GOC:TermGenie] synonym: "miRNA binding involved in cosuppression" RELATED [GOC:TermGenie] synonym: "miRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] synonym: "miRNA binding involved in posttranscriptional gene silencing" EXACT [] synonym: "miRNA binding involved in PTGS" EXACT [GOC:TermGenie] synonym: "miRNA binding involved in quelling" EXACT [GOC:TermGenie] is_obsolete: true created_by: jl creation_date: 2014-07-31T10:22:18Z [Term] id: GO:1903231 name: mRNA binding involved in posttranscriptional gene silencing namespace: molecular_function def: "Any mRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:BHF_miRNA, GOC:jl, GOC:TermGenie] synonym: "mRNA binding involved in cosuppression" RELATED [GOC:TermGenie] synonym: "mRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] synonym: "mRNA binding involved in PTGS" EXACT [GOC:TermGenie] synonym: "mRNA binding involved in quelling" EXACT [GOC:TermGenie] is_a: GO:0003729 ! mRNA binding is_a: GO:0150100 ! RNA binding involved in posttranscriptional gene silencing intersection_of: GO:0003729 ! mRNA binding intersection_of: part_of GO:0016441 ! posttranscriptional gene silencing created_by: jl creation_date: 2014-07-31T10:30:43Z [Term] id: GO:1903232 name: melanosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774] synonym: "melanosome formation" EXACT [GOC:TermGenie] is_a: GO:0032438 ! melanosome organization is_a: GO:0070925 ! organelle assembly created_by: bf creation_date: 2014-07-31T10:41:38Z [Term] id: GO:1903233 name: regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter relationship: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter created_by: pad creation_date: 2014-07-31T11:54:33Z [Term] id: GO:1903234 name: negative regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) synonym: "down regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter relationship: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter created_by: pad creation_date: 2014-07-31T11:54:40Z [Term] id: GO:1903235 name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) synonym: "activation of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter relationship: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter created_by: pad creation_date: 2014-07-31T11:54:46Z [Term] id: GO:1903236 name: regulation of leukocyte tethering or rolling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050901 ! leukocyte tethering or rolling relationship: regulates GO:0050901 ! leukocyte tethering or rolling created_by: als creation_date: 2014-07-31T13:07:48Z [Term] id: GO:1903237 name: negative regulation of leukocyte tethering or rolling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] synonym: "down regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte tethering or rolling" NARROW [GOC:TermGenie] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:1903236 ! regulation of leukocyte tethering or rolling is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050901 ! leukocyte tethering or rolling relationship: negatively_regulates GO:0050901 ! leukocyte tethering or rolling created_by: als creation_date: 2014-07-31T13:07:55Z [Term] id: GO:1903238 name: positive regulation of leukocyte tethering or rolling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] synonym: "activation of leukocyte tethering or rolling" NARROW [GOC:TermGenie] synonym: "up regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:1903236 ! regulation of leukocyte tethering or rolling is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050901 ! leukocyte tethering or rolling relationship: positively_regulates GO:0050901 ! leukocyte tethering or rolling created_by: als creation_date: 2014-07-31T13:08:01Z [Term] id: GO:1903239 name: obsolete regulation of positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [] synonym: "regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2014-07-31T17:00:17Z [Term] id: GO:1903240 name: obsolete negative regulation of positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "down regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "down-regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "down-regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "downregulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "downregulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] synonym: "inhibition of positive regulation of the force of heart contraction by chemical signal" NARROW [GOC:TermGenie] synonym: "inhibition of positive regulation of the force of heart muscle contraction by chemical signal" NARROW [GOC:TermGenie] synonym: "negative regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [] synonym: "negative regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2014-07-31T17:00:23Z [Term] id: GO:1903241 name: U2-type prespliceosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752] synonym: "GT-AG prespliceosome assembly" NARROW [GOC:TermGenie] synonym: "GT-AG prespliceosome formation" NARROW [GOC:TermGenie] synonym: "major prespliceosome assembly" EXACT [GOC:TermGenie] synonym: "major prespliceosome formation" EXACT [GOC:TermGenie] synonym: "mammalian U2-type spliceosomal complex A assembly" NARROW [GOC:TermGenie] synonym: "mammalian U2-type spliceosomal complex A formation" NARROW [GOC:TermGenie] synonym: "U2-type prespliceosome formation" EXACT [GOC:TermGenie] synonym: "yeast U2-type spliceosomal complex B assembly" NARROW [GOC:TermGenie] synonym: "yeast U2-type spliceosomal complex B formation" NARROW [GOC:TermGenie] is_a: GO:0000245 ! spliceosomal complex assembly created_by: mah creation_date: 2014-08-01T14:33:45Z [Term] id: GO:1903242 name: regulation of cardiac muscle hypertrophy in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress relationship: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress created_by: rl creation_date: 2014-08-01T16:31:36Z [Term] id: GO:1903243 name: negative regulation of cardiac muscle hypertrophy in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] synonym: "down regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0010616 ! negative regulation of cardiac muscle adaptation is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress relationship: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress created_by: rl creation_date: 2014-08-01T16:31:42Z [Term] id: GO:1903244 name: positive regulation of cardiac muscle hypertrophy in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] synonym: "activation of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0010615 ! positive regulation of cardiac muscle adaptation is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress relationship: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress created_by: rl creation_date: 2014-08-01T16:31:48Z [Term] id: GO:1903245 name: obsolete regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2014-08-04T11:53:54Z [Term] id: GO:1903246 name: obsolete negative regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "down regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "down regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "down-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "down-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "downregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "downregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "downregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "downregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "inhibition of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "inhibition of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "inhibition of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "inhibition of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "negative regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "negative regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "negative regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2014-08-04T11:54:00Z [Term] id: GO:1903247 name: obsolete positive regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. See discussion at https://github.com/geneontology/go-ontology/issues/14733 synonym: "activation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "activation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "activation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "activation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "activation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "positive regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "positive regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "positive regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "up regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "up-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "up-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "upregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "upregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] synonym: "upregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] synonym: "upregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] is_obsolete: true created_by: rl creation_date: 2014-08-04T11:54:06Z [Term] id: GO:1903248 name: regulation of citrulline biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] synonym: "regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "regulation of citrulline synthesis" EXACT [GOC:TermGenie] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019240 ! citrulline biosynthetic process relationship: regulates GO:0019240 ! citrulline biosynthetic process created_by: rl creation_date: 2014-08-04T15:24:34Z [Term] id: GO:1903249 name: negative regulation of citrulline biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] synonym: "down regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "down regulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "down-regulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "downregulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of citrulline anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of citrulline biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of citrulline biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of citrulline formation" NARROW [GOC:TermGenie] synonym: "inhibition of citrulline synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "negative regulation of citrulline synthesis" EXACT [GOC:TermGenie] is_a: GO:1903248 ! regulation of citrulline biosynthetic process is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019240 ! citrulline biosynthetic process relationship: negatively_regulates GO:0019240 ! citrulline biosynthetic process created_by: rl creation_date: 2014-08-04T15:24:46Z [Term] id: GO:1903250 name: positive regulation of citrulline biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] synonym: "activation of citrulline anabolism" NARROW [GOC:TermGenie] synonym: "activation of citrulline biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of citrulline biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of citrulline formation" NARROW [GOC:TermGenie] synonym: "activation of citrulline synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "positive regulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline formation" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline synthesis" EXACT [GOC:TermGenie] is_a: GO:1903248 ! regulation of citrulline biosynthetic process is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019240 ! citrulline biosynthetic process relationship: positively_regulates GO:0019240 ! citrulline biosynthetic process created_by: rl creation_date: 2014-08-04T15:24:52Z [Term] id: GO:1903251 name: multi-ciliated epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224] synonym: "multiciliate cell differentiation" BROAD [] is_a: GO:0030855 ! epithelial cell differentiation created_by: tb creation_date: 2014-08-05T19:21:21Z [Term] id: GO:1903252 name: hercynylcysteine sulfoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "hercynylcysteine sulfoxide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: mah creation_date: 2014-08-06T09:13:50Z [Term] id: GO:1903253 name: hercynylcysteine sulfoxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "hercynylcysteine sulfoxide anabolism" EXACT [GOC:TermGenie] synonym: "hercynylcysteine sulfoxide biosynthesis" EXACT [GOC:TermGenie] synonym: "hercynylcysteine sulfoxide formation" EXACT [GOC:TermGenie] synonym: "hercynylcysteine sulfoxide synthesis" EXACT [GOC:TermGenie] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052703 ! cellular modified histidine biosynthetic process is_a: GO:1903252 ! hercynylcysteine sulfoxide metabolic process created_by: mah creation_date: 2014-08-06T09:14:00Z [Term] id: GO:1903254 name: hercynylselenocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "hercynylselenocysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0001887 ! selenium compound metabolic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: mah creation_date: 2014-08-06T09:14:08Z [Term] id: GO:1903255 name: hercynylselenocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "hercynylselenocysteine anabolism" EXACT [GOC:TermGenie] synonym: "hercynylselenocysteine biosynthesis" EXACT [GOC:TermGenie] synonym: "hercynylselenocysteine formation" EXACT [GOC:TermGenie] synonym: "hercynylselenocysteine synthesis" EXACT [GOC:TermGenie] is_a: GO:0052703 ! cellular modified histidine biosynthetic process is_a: GO:1903254 ! hercynylselenocysteine metabolic process created_by: mah creation_date: 2014-08-06T09:14:16Z [Term] id: GO:1903256 name: selenoneine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "L-selenoneine metabolic process" NARROW [] synonym: "selenoneine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0052701 ! cellular modified histidine metabolic process created_by: mah creation_date: 2014-08-06T09:14:24Z [Term] id: GO:1903257 name: selenoneine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] synonym: "L-selenoneine biosynthetic process" NARROW [] synonym: "selenoneine anabolism" EXACT [GOC:TermGenie] synonym: "selenoneine biosynthesis" EXACT [GOC:TermGenie] synonym: "selenoneine formation" EXACT [GOC:TermGenie] synonym: "selenoneine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0052703 ! cellular modified histidine biosynthetic process is_a: GO:1903256 ! selenoneine metabolic process created_by: mah creation_date: 2014-08-06T09:14:33Z [Term] id: GO:1903258 name: sorbose import across plasma membrane namespace: biological_process def: "The process in which sorbose is transported from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:2878925] synonym: "sorbose import into cell" EXACT [] is_a: GO:0140271 ! hexose import across plasma membrane created_by: mah creation_date: 2014-08-06T09:21:53Z [Term] id: GO:1903259 name: exon-exon junction complex disassembly namespace: biological_process def: "The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911] synonym: "EJC disassembly" EXACT [GOC:TermGenie] is_a: GO:0032984 ! protein-containing complex disassembly created_by: sart creation_date: 2014-08-06T09:44:06Z [Term] id: GO:1903260 name: protein localization to mating projection tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mating projection tip." [GO_REF:0000087, GOC:TermGenie, PMID:11952834] synonym: "protein localisation in mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localisation to mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localization in mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localization to conjugation tube tip" NARROW [] synonym: "protein localization to shmoo tip" NARROW [] is_a: GO:1990151 ! protein localization to cell tip created_by: mah creation_date: 2014-08-06T13:26:14Z [Term] id: GO:1903264 name: nitrate reductase activity involved in anaerobic electron transport chain namespace: molecular_function def: "Any nitrate reductase activity that is involved in anaerobic electron transport chain." [GO_REF:0000061, GOC:dos, GOC:TermGenie, PMID:12910261] synonym: "nitrate reductase (acceptor) involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] synonym: "nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] synonym: "nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] synonym: "respiratory nitrate reductase activity involved in anaerobic electron transport chain" NARROW [GOC:TermGenie] is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0009055 ! electron transfer activity intersection_of: GO:0008940 ! nitrate reductase activity intersection_of: part_of GO:0019645 ! anaerobic electron transport chain relationship: part_of GO:0019645 ! anaerobic electron transport chain created_by: dos creation_date: 2014-08-07T10:07:07Z [Term] id: GO:1903265 name: positive regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807] synonym: "activation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway relationship: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway created_by: bf creation_date: 2014-08-07T10:26:59Z [Term] id: GO:1903266 name: regulation of ornithine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). synonym: "regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ornithine degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0090368 ! regulation of ornithine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006593 ! ornithine catabolic process relationship: regulates GO:0006593 ! ornithine catabolic process created_by: bhm creation_date: 2014-08-08T08:29:33Z [Term] id: GO:1903267 name: negative regulation of ornithine catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). synonym: "down regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "downregulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "inhibition of ornithine breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of ornithine catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ornithine catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ornithine degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ornithine degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:1903266 ! regulation of ornithine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006593 ! ornithine catabolic process relationship: negatively_regulates GO:0006593 ! ornithine catabolic process created_by: bhm creation_date: 2014-08-08T08:29:42Z [Term] id: GO:1903268 name: positive regulation of ornithine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] synonym: "activation of ornithine breakdown" NARROW [GOC:TermGenie] synonym: "activation of ornithine catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ornithine catabolism" NARROW [GOC:TermGenie] synonym: "activation of ornithine degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "up regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ornithine degradation" EXACT [GOC:TermGenie] synonym: "upregulation of ornithine breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ornithine catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ornithine catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ornithine degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:1903266 ! regulation of ornithine catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006593 ! ornithine catabolic process relationship: positively_regulates GO:0006593 ! ornithine catabolic process created_by: bhm creation_date: 2014-08-08T08:29:50Z [Term] id: GO:1903269 name: ornithine carbamoyltransferase inhibitor complex namespace: cellular_component def: "A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12679340] comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). synonym: "ornithine carbamoyltransferase arginase complex" NARROW [] synonym: "OTC-ARGI complex" NARROW [] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-08-08T08:47:38Z [Term] id: GO:1903270 name: regulation of cytoplasmic translational elongation through polyproline stretches namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] is_a: GO:1900247 ! regulation of cytoplasmic translational elongation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches relationship: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches created_by: mcc creation_date: 2014-08-08T14:53:59Z [Term] id: GO:1903271 name: negative regulation of cytoplasmic translational elongation through polyproline stretches namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] synonym: "down regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie] is_a: GO:1900248 ! negative regulation of cytoplasmic translational elongation is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches relationship: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches created_by: mcc creation_date: 2014-08-08T14:54:08Z [Term] id: GO:1903272 name: positive regulation of cytoplasmic translational elongation through polyproline stretches namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] synonym: "activation of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] is_a: GO:1900249 ! positive regulation of cytoplasmic translational elongation is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches relationship: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches created_by: mcc creation_date: 2014-08-08T14:54:16Z [Term] id: GO:1903276 name: regulation of sodium ion export across plasma membrane namespace: biological_process alt_id: GO:1903273 def: "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "regulation of sodium export" RELATED [GOC:TermGenie] synonym: "regulation of sodium ion export" RELATED [] synonym: "regulation of sodium ion export from cell" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036376 ! sodium ion export across plasma membrane relationship: regulates GO:0036376 ! sodium ion export across plasma membrane created_by: rl creation_date: 2014-08-08T17:06:46Z [Term] id: GO:1903277 name: negative regulation of sodium ion export across plasma membrane namespace: biological_process alt_id: GO:1903274 def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "down regulation of sodium export" RELATED [GOC:TermGenie] synonym: "down regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "down regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium export" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "downregulation of sodium export" RELATED [GOC:TermGenie] synonym: "downregulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "downregulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "inhibition of sodium export" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion export" NARROW [GOC:TermGenie] synonym: "inhibition of sodium ion export from cell" NARROW [GOC:TermGenie] synonym: "negative regulation of sodium export" RELATED [GOC:TermGenie] synonym: "negative regulation of sodium ion export" RELATED [] synonym: "negative regulation of sodium ion export from cell" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036376 ! sodium ion export across plasma membrane relationship: negatively_regulates GO:0036376 ! sodium ion export across plasma membrane created_by: rl creation_date: 2014-08-08T17:10:22Z [Term] id: GO:1903278 name: positive regulation of sodium ion export across plasma membrane namespace: biological_process alt_id: GO:1903275 def: "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] synonym: "activation of sodium export" NARROW [GOC:TermGenie] synonym: "activation of sodium ion export" NARROW [GOC:TermGenie] synonym: "activation of sodium ion export from cell" NARROW [GOC:TermGenie] synonym: "positive regulation of sodium export" RELATED [GOC:TermGenie] synonym: "positive regulation of sodium ion export" RELATED [] synonym: "positive regulation of sodium ion export from cell" EXACT [] synonym: "up regulation of sodium export" RELATED [GOC:TermGenie] synonym: "up regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "up regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium export" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] synonym: "upregulation of sodium export" RELATED [GOC:TermGenie] synonym: "upregulation of sodium ion export" RELATED [GOC:TermGenie] synonym: "upregulation of sodium ion export from cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036376 ! sodium ion export across plasma membrane relationship: positively_regulates GO:0036376 ! sodium ion export across plasma membrane created_by: rl creation_date: 2014-08-08T17:10:30Z [Term] id: GO:1903279 name: regulation of calcium:sodium antiporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] synonym: "regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005432 ! calcium:sodium antiporter activity relationship: regulates GO:0005432 ! calcium:sodium antiporter activity created_by: rl creation_date: 2014-08-11T12:53:30Z [Term] id: GO:1903280 name: negative regulation of calcium:sodium antiporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] synonym: "down regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "down regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "down regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "down-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "downregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "downregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "downregulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "inhibition of calcium:sodium antiporter activity" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "inhibition of sodium/calcium exchanger" NARROW [GOC:TermGenie] synonym: "inhibition of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "negative regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "negative regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005432 ! calcium:sodium antiporter activity relationship: negatively_regulates GO:0005432 ! calcium:sodium antiporter activity created_by: rl creation_date: 2014-08-11T12:53:38Z [Term] id: GO:1903281 name: positive regulation of calcium:sodium antiporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] synonym: "activation of calcium:sodium antiporter activity" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "activation of sodium/calcium exchanger" NARROW [GOC:TermGenie] synonym: "activation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "positive regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "positive regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "positive regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "up regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "up regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "up regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "up-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] synonym: "upregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] synonym: "upregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] synonym: "upregulation of sodium:calcium exchange" RELATED [GOC:TermGenie] is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005432 ! calcium:sodium antiporter activity relationship: positively_regulates GO:0005432 ! calcium:sodium antiporter activity created_by: rl creation_date: 2014-08-11T12:53:47Z [Term] id: GO:1903282 name: regulation of glutathione peroxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] is_a: GO:2000468 ! regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004602 ! glutathione peroxidase activity relationship: regulates GO:0004602 ! glutathione peroxidase activity created_by: bf creation_date: 2014-08-11T13:14:13Z [Term] id: GO:1903283 name: negative regulation of glutathione peroxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "down regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "downregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "inhibition of glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of GSH peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] is_a: GO:1903282 ! regulation of glutathione peroxidase activity is_a: GO:2000469 ! negative regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004602 ! glutathione peroxidase activity relationship: negatively_regulates GO:0004602 ! glutathione peroxidase activity created_by: bf creation_date: 2014-08-11T13:14:22Z [Term] id: GO:1903284 name: positive regulation of glutathione peroxidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] synonym: "activation of glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of GSH peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "activation of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "enhancement of GPX activity" EXACT [PMID:23507046] synonym: "positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "up regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of GSH peroxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] synonym: "upregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] is_a: GO:1903282 ! regulation of glutathione peroxidase activity is_a: GO:2000470 ! positive regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004602 ! glutathione peroxidase activity relationship: positively_regulates GO:0004602 ! glutathione peroxidase activity created_by: bf creation_date: 2014-08-11T13:14:30Z [Term] id: GO:1903285 name: positive regulation of hydrogen peroxide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] synonym: "activation of detoxification of H2O2" RELATED [GOC:TermGenie] synonym: "activation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "activation of H2O2 catabolic process" NARROW [GOC:TermGenie] synonym: "activation of H2O2 scavenging" RELATED [GOC:TermGenie] synonym: "activation of hydrogen peroxide breakdown" NARROW [GOC:TermGenie] synonym: "activation of hydrogen peroxide catabolic process" NARROW [GOC:TermGenie] synonym: "activation of hydrogen peroxide catabolism" NARROW [GOC:TermGenie] synonym: "activation of hydrogen peroxide degradation" NARROW [GOC:TermGenie] synonym: "activation of hydrogen peroxide removal" RELATED [GOC:TermGenie] synonym: "activation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] synonym: "positive regulation of detoxification of H2O2" RELATED [GOC:TermGenie] synonym: "positive regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "positive regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of H2O2 scavenging" RELATED [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] synonym: "up regulation of detoxification of H2O2" RELATED [GOC:TermGenie] synonym: "up regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "up regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of H2O2 scavenging" RELATED [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] synonym: "up-regulation of detoxification of H2O2" RELATED [GOC:TermGenie] synonym: "up-regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "up-regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of H2O2 scavenging" RELATED [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] synonym: "upregulation of detoxification of H2O2" RELATED [GOC:TermGenie] synonym: "upregulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "upregulation of H2O2 catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of H2O2 scavenging" RELATED [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process relationship: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process created_by: bf creation_date: 2014-08-11T13:28:40Z [Term] id: GO:1903286 name: regulation of potassium ion import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "regulation of potassium import" EXACT [GOC:TermGenie] synonym: "regulation of potassium ion uptake" EXACT [GOC:TermGenie] is_a: GO:1901379 ! regulation of potassium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990573 ! potassium ion import across plasma membrane relationship: regulates GO:1990573 ! potassium ion import across plasma membrane created_by: rl creation_date: 2014-08-11T14:26:16Z [Term] id: GO:1903287 name: negative regulation of potassium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "down regulation of potassium import" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium import" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "downregulation of potassium import" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion import" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion uptake" BROAD [GOC:TermGenie] synonym: "inhibition of potassium import" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion import" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of potassium import" BROAD [GOC:TermGenie] synonym: "negative regulation of potassium ion import" BROAD [] synonym: "negative regulation of potassium ion uptake" BROAD [GOC:TermGenie] is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport is_a: GO:1903286 ! regulation of potassium ion import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990573 ! potassium ion import across plasma membrane relationship: negatively_regulates GO:1990573 ! potassium ion import across plasma membrane created_by: rl creation_date: 2014-08-11T14:26:24Z [Term] id: GO:1903288 name: positive regulation of potassium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] synonym: "activation of potassium import" NARROW [GOC:TermGenie] synonym: "activation of potassium ion import" NARROW [GOC:TermGenie] synonym: "activation of potassium ion uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of potassium import" EXACT [GOC:TermGenie] synonym: "positive regulation of potassium ion import" BROAD [] synonym: "positive regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "up regulation of potassium import" EXACT [GOC:TermGenie] synonym: "up regulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "up regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium import" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium ion uptake" EXACT [GOC:TermGenie] synonym: "upregulation of potassium import" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion import" EXACT [GOC:TermGenie] synonym: "upregulation of potassium ion uptake" EXACT [GOC:TermGenie] is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport is_a: GO:1903286 ! regulation of potassium ion import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990573 ! potassium ion import across plasma membrane relationship: positively_regulates GO:1990573 ! potassium ion import across plasma membrane created_by: rl creation_date: 2014-08-11T14:26:32Z [Term] id: GO:1903289 name: obsolete regulation of ATP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "regulation of ATP hydrolysis" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:0043462 created_by: rl creation_date: 2014-08-11T14:36:39Z [Term] id: GO:1903290 name: obsolete negative regulation of ATP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "down regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "down regulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "down-regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "downregulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "downregulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "inhibition of ATP breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of ATP catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ATP catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ATP degradation" NARROW [GOC:TermGenie] synonym: "inhibition of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP hydrolysis" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:0032780 created_by: rl creation_date: 2014-08-11T14:36:47Z [Term] id: GO:1903291 name: obsolete positive regulation of ATP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "activation of ATP breakdown" NARROW [GOC:TermGenie] synonym: "activation of ATP catabolic process" NARROW [GOC:TermGenie] synonym: "activation of ATP catabolism" NARROW [GOC:TermGenie] synonym: "activation of ATP degradation" NARROW [GOC:TermGenie] synonym: "activation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "up regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "up regulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "up-regulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP hydrolysis" NARROW [GOC:TermGenie] synonym: "upregulation of ATP breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ATP catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ATP catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ATP degradation" EXACT [GOC:TermGenie] synonym: "upregulation of ATP hydrolysis" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:0032781 created_by: rl creation_date: 2014-08-11T14:36:55Z [Term] id: GO:1903292 name: protein localization to Golgi membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] is_a: GO:0034067 ! protein localization to Golgi apparatus is_a: GO:0072657 ! protein localization to membrane created_by: mah creation_date: 2014-08-12T14:22:31Z [Term] id: GO:1903293 name: phosphatase complex namespace: cellular_component def: "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2014-08-13T10:25:32Z [Term] id: GO:1903294 name: regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061535 ! glutamate secretion, neurotransmission relationship: regulates GO:0061535 ! glutamate secretion, neurotransmission created_by: pad creation_date: 2014-08-13T13:54:15Z [Term] id: GO:1903295 name: negative regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0014050 ! negative regulation of glutamate secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission relationship: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission created_by: pad creation_date: 2014-08-13T13:54:23Z [Term] id: GO:1903296 name: positive regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014049 ! positive regulation of glutamate secretion is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission relationship: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission created_by: pad creation_date: 2014-08-13T13:54:31Z [Term] id: GO:1903297 name: regulation of hypoxia-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of hypoxia-induced apoptosis" RELATED [GOC:bf] synonym: "regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf] is_a: GO:1900037 ! regulation of cellular response to hypoxia is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia relationship: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia created_by: bf creation_date: 2014-08-14T14:47:48Z [Term] id: GO:1903298 name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hypoxia" NARROW [GOC:TermGenie] synonym: "negative regulation of hypoxia-induced apoptosis" RELATED [GOC:bf] synonym: "negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf] synonym: "protection against hypoxia-induced apoptosis" RELATED [GOC:bf] is_a: GO:1900038 ! negative regulation of cellular response to hypoxia is_a: GO:1903297 ! regulation of hypoxia-induced intrinsic apoptotic signaling pathway is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia relationship: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia created_by: bf creation_date: 2014-08-14T14:47:56Z [Term] id: GO:1903299 name: regulation of hexokinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004396 ! hexokinase activity relationship: regulates GO:0004396 ! hexokinase activity created_by: mr creation_date: 2014-08-15T23:17:53Z [Term] id: GO:1903300 name: negative regulation of hexokinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "down regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "down regulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "down regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "down regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "down regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "down regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "down regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "down regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "down-regulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "down-regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "down-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "down-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "downregulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "downregulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "downregulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "downregulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "downregulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "downregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "downregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase (phosphorylating)" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase D" RELATED [GOC:TermGenie] synonym: "inhibition of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "inhibition of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "inhibition of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "negative regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "negative regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "negative regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "negative regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:1903299 ! regulation of hexokinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004396 ! hexokinase activity relationship: negatively_regulates GO:0004396 ! hexokinase activity created_by: mr creation_date: 2014-08-15T23:18:01Z [Term] id: GO:1903301 name: positive regulation of hexokinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "activation of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase (phosphorylating)" NARROW [GOC:TermGenie] synonym: "activation of hexokinase activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase D" RELATED [GOC:TermGenie] synonym: "activation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "activation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "activation of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "positive regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "positive regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "positive regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "positive regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "up regulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "up regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "up regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "up regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "up regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "up regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "up regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "up-regulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "up-regulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "up-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "up-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "upregulation of hexokinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hexokinase D" RELATED [GOC:TermGenie] synonym: "upregulation of hexokinase type I activity" NARROW [GOC:TermGenie] synonym: "upregulation of hexokinase type II activity" NARROW [GOC:TermGenie] synonym: "upregulation of hexokinase type III activity" NARROW [GOC:TermGenie] synonym: "upregulation of hexokinase type IV" RELATED [GOC:TermGenie] synonym: "upregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] synonym: "upregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:1903299 ! regulation of hexokinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004396 ! hexokinase activity relationship: positively_regulates GO:0004396 ! hexokinase activity created_by: mr creation_date: 2014-08-15T23:18:09Z [Term] id: GO:1903302 name: regulation of pyruvate kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] is_a: GO:0006110 ! regulation of glycolytic process is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004743 ! pyruvate kinase activity relationship: regulates GO:0004743 ! pyruvate kinase activity created_by: mr creation_date: 2014-08-15T23:25:51Z [Term] id: GO:1903303 name: negative regulation of pyruvate kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "down regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of pyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of pyruvate kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] is_a: GO:0045820 ! negative regulation of glycolytic process is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1903302 ! regulation of pyruvate kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004743 ! pyruvate kinase activity relationship: negatively_regulates GO:0004743 ! pyruvate kinase activity created_by: mr creation_date: 2014-08-15T23:25:58Z [Term] id: GO:1903304 name: positive regulation of pyruvate kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] synonym: "activation of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie] synonym: "activation of pyruvate kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of pyruvate kinase activity" EXACT [GOC:TermGenie] is_a: GO:0045821 ! positive regulation of glycolytic process is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1903302 ! regulation of pyruvate kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004743 ! pyruvate kinase activity relationship: positively_regulates GO:0004743 ! pyruvate kinase activity created_by: mr creation_date: 2014-08-15T23:26:06Z [Term] id: GO:1903305 name: regulation of regulated secretory pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045055 ! regulated exocytosis relationship: regulates GO:0045055 ! regulated exocytosis created_by: pad creation_date: 2014-08-18T10:04:53Z [Term] id: GO:1903306 name: negative regulation of regulated secretory pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. synonym: "down regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "inhibition of regulated secretory pathway" NARROW [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045055 ! regulated exocytosis relationship: negatively_regulates GO:0045055 ! regulated exocytosis created_by: pad creation_date: 2014-08-18T10:05:02Z [Term] id: GO:1903307 name: positive regulation of regulated secretory pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. synonym: "activation of regulated secretory pathway" NARROW [GOC:TermGenie] synonym: "up regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of regulated secretory pathway" EXACT [GOC:TermGenie] is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045055 ! regulated exocytosis relationship: positively_regulates GO:0045055 ! regulated exocytosis created_by: pad creation_date: 2014-08-18T10:05:10Z [Term] id: GO:1903311 name: regulation of mRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of mRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016071 ! mRNA metabolic process relationship: regulates GO:0016071 ! mRNA metabolic process created_by: vw creation_date: 2014-08-18T11:52:26Z [Term] id: GO:1903312 name: negative regulation of mRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mRNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of mRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016071 ! mRNA metabolic process relationship: negatively_regulates GO:0016071 ! mRNA metabolic process created_by: vw creation_date: 2014-08-18T11:52:34Z [Term] id: GO:1903313 name: positive regulation of mRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of mRNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of mRNA metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1903311 ! regulation of mRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016071 ! mRNA metabolic process relationship: positively_regulates GO:0016071 ! mRNA metabolic process created_by: vw creation_date: 2014-08-18T11:52:42Z [Term] id: GO:1903314 name: regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071941 ! nitrogen cycle metabolic process relationship: regulates GO:0071941 ! nitrogen cycle metabolic process created_by: vw creation_date: 2014-08-18T12:57:34Z [Term] id: GO:1903315 name: negative regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process relationship: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process created_by: vw creation_date: 2014-08-18T12:57:42Z [Term] id: GO:1903316 name: positive regulation of nitrogen cycle metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071941 ! nitrogen cycle metabolic process relationship: positively_regulates GO:0071941 ! nitrogen cycle metabolic process created_by: vw creation_date: 2014-08-18T12:57:50Z [Term] id: GO:1903317 name: regulation of protein maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051604 ! protein maturation relationship: regulates GO:0051604 ! protein maturation created_by: vw creation_date: 2014-08-18T12:59:07Z [Term] id: GO:1903318 name: negative regulation of protein maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie] synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051604 ! protein maturation relationship: negatively_regulates GO:0051604 ! protein maturation created_by: vw creation_date: 2014-08-18T12:59:15Z [Term] id: GO:1903319 name: positive regulation of protein maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of protein maturation" NARROW [GOC:TermGenie] synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051604 ! protein maturation relationship: positively_regulates GO:0051604 ! protein maturation created_by: vw creation_date: 2014-08-18T12:59:23Z [Term] id: GO:1903320 name: regulation of protein modification by small protein conjugation or removal namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070647 ! protein modification by small protein conjugation or removal relationship: regulates GO:0070647 ! protein modification by small protein conjugation or removal created_by: vw creation_date: 2014-08-18T13:01:00Z [Term] id: GO:1903321 name: negative regulation of protein modification by small protein conjugation or removal namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "down-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "downregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "inhibition of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal relationship: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal created_by: vw creation_date: 2014-08-18T13:01:08Z [Term] id: GO:1903322 name: positive regulation of protein modification by small protein conjugation or removal namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie] synonym: "up regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "up-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "upregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal relationship: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal created_by: vw creation_date: 2014-08-18T13:01:15Z [Term] id: GO:1903323 name: regulation of snoRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of snoRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016074 ! snoRNA metabolic process relationship: regulates GO:0016074 ! snoRNA metabolic process created_by: vw creation_date: 2014-08-18T13:05:17Z [Term] id: GO:1903324 name: negative regulation of snoRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of snoRNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of snoRNA metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of snoRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:1903323 ! regulation of snoRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016074 ! snoRNA metabolic process relationship: negatively_regulates GO:0016074 ! snoRNA metabolic process created_by: vw creation_date: 2014-08-18T13:05:25Z [Term] id: GO:1903325 name: positive regulation of snoRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of snoRNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of snoRNA metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of snoRNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of snoRNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of snoRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1903323 ! regulation of snoRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016074 ! snoRNA metabolic process relationship: positively_regulates GO:0016074 ! snoRNA metabolic process created_by: vw creation_date: 2014-08-18T13:05:33Z [Term] id: GO:1903326 name: regulation of tRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006399 ! tRNA metabolic process relationship: regulates GO:0006399 ! tRNA metabolic process created_by: vw creation_date: 2014-08-18T13:08:50Z [Term] id: GO:1903327 name: negative regulation of tRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006399 ! tRNA metabolic process relationship: negatively_regulates GO:0006399 ! tRNA metabolic process created_by: vw creation_date: 2014-08-18T13:08:58Z [Term] id: GO:1903328 name: positive regulation of tRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006399 ! tRNA metabolic process relationship: positively_regulates GO:0006399 ! tRNA metabolic process created_by: vw creation_date: 2014-08-18T13:09:06Z [Term] id: GO:1903329 name: regulation of iron-sulfur cluster assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016226 ! iron-sulfur cluster assembly relationship: regulates GO:0016226 ! iron-sulfur cluster assembly created_by: vw creation_date: 2014-08-18T13:12:41Z [Term] id: GO:1903330 name: negative regulation of iron-sulfur cluster assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "down regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "downregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "inhibition of iron-sulfur cluster assembly" NARROW [GOC:TermGenie] synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly relationship: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly created_by: vw creation_date: 2014-08-18T13:12:50Z [Term] id: GO:1903331 name: positive regulation of iron-sulfur cluster assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of iron-sulfur cluster assembly" NARROW [GOC:TermGenie] synonym: "activation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of iron-sulphur cluster assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "up regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016226 ! iron-sulfur cluster assembly relationship: positively_regulates GO:0016226 ! iron-sulfur cluster assembly created_by: vw creation_date: 2014-08-18T13:12:57Z [Term] id: GO:1903332 name: regulation of protein folding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006457 ! protein folding relationship: regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:34Z [Term] id: GO:1903333 name: negative regulation of protein folding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "down regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "down regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "down regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "down regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "down regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "down regulation of protein folding" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "down-regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "down-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "down-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of protein folding" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "downregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "downregulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "downregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "downregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "downregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "downregulation of protein folding" EXACT [GOC:TermGenie] synonym: "inhibition of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "inhibition of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "inhibition of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "inhibition of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "inhibition of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "inhibition of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "inhibition of protein folding" NARROW [GOC:TermGenie] synonym: "negative regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "negative regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "negative regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "negative regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006457 ! protein folding relationship: negatively_regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:42Z [Term] id: GO:1903334 name: positive regulation of protein folding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "activation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "activation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "activation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "activation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "activation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "activation of protein folding" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "positive regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "positive regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "positive regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "up regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "up regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "up regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "up regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "up regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up regulation of protein folding" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "up-regulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "up-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "up-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of protein folding" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of beta-tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] synonym: "upregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] synonym: "upregulation of co-chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of co-chaperonin activity" RELATED [GOC:TermGenie] synonym: "upregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] synonym: "upregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] synonym: "upregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] synonym: "upregulation of protein folding" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006457 ! protein folding relationship: positively_regulates GO:0006457 ! protein folding created_by: vw creation_date: 2014-08-18T13:14:50Z [Term] id: GO:1903335 name: regulation of vacuolar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007034 ! vacuolar transport relationship: regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:04Z [Term] id: GO:1903336 name: negative regulation of vacuolar transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007034 ! vacuolar transport relationship: negatively_regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:11Z [Term] id: GO:1903337 name: positive regulation of vacuolar transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007034 ! vacuolar transport relationship: positively_regulates GO:0007034 ! vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:19Z [Term] id: GO:1903338 name: regulation of cell wall organization or biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071554 ! cell wall organization or biogenesis relationship: regulates GO:0071554 ! cell wall organization or biogenesis created_by: vw creation_date: 2014-08-18T13:20:50Z [Term] id: GO:1903339 name: negative regulation of cell wall organization or biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "down regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "downregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cell wall organisation or biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie] synonym: "inhibition of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071554 ! cell wall organization or biogenesis relationship: negatively_regulates GO:0071554 ! cell wall organization or biogenesis created_by: vw creation_date: 2014-08-18T13:20:58Z [Term] id: GO:1903340 name: positive regulation of cell wall organization or biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of cell wall organisation or biogenesis" NARROW [GOC:TermGenie] synonym: "activation of cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "activation of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie] synonym: "activation of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie] synonym: "activation of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "up regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "upregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071554 ! cell wall organization or biogenesis relationship: positively_regulates GO:0071554 ! cell wall organization or biogenesis created_by: vw creation_date: 2014-08-18T13:21:06Z [Term] id: GO:1903341 name: regulation of meiotic DNA double-strand break formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042138 ! meiotic DNA double-strand break formation relationship: regulates GO:0042138 ! meiotic DNA double-strand break formation created_by: mcc creation_date: 2014-08-18T21:31:54Z [Term] id: GO:1903342 name: negative regulation of meiotic DNA double-strand break formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] synonym: "down regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation relationship: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation created_by: mcc creation_date: 2014-08-18T21:32:03Z [Term] id: GO:1903343 name: positive regulation of meiotic DNA double-strand break formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] synonym: "activation of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation relationship: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation created_by: mcc creation_date: 2014-08-18T21:32:11Z [Term] id: GO:1903344 name: regulation of protein polyglycylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018094 ! protein polyglycylation relationship: regulates GO:0018094 ! protein polyglycylation created_by: sart creation_date: 2014-08-19T09:32:08Z [Term] id: GO:1903345 name: negative regulation of protein polyglycylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie] synonym: "down regulation of protein polyglycylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polyglycylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein polyglycylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein polyglycylation" NARROW [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1903344 ! regulation of protein polyglycylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018094 ! protein polyglycylation relationship: negatively_regulates GO:0018094 ! protein polyglycylation created_by: sart creation_date: 2014-08-19T09:32:16Z [Term] id: GO:1903346 name: positive regulation of protein polyglycylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie, PMID:21298005] synonym: "activation of protein polyglycylation" NARROW [GOC:TermGenie] synonym: "up regulation of protein polyglycylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polyglycylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein polyglycylation" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1903344 ! regulation of protein polyglycylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018094 ! protein polyglycylation relationship: positively_regulates GO:0018094 ! protein polyglycylation created_by: sart creation_date: 2014-08-19T09:32:24Z [Term] id: GO:1903347 name: negative regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie] synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070830 ! bicellular tight junction assembly relationship: negatively_regulates GO:0070830 ! bicellular tight junction assembly created_by: pr creation_date: 2014-08-19T11:02:14Z [Term] id: GO:1903348 name: positive regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction formation" NARROW [GOC:TermGenie] synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901890 ! positive regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070830 ! bicellular tight junction assembly relationship: positively_regulates GO:0070830 ! bicellular tight junction assembly created_by: pr creation_date: 2014-08-19T11:05:06Z [Term] id: GO:1903349 name: omegasome membrane namespace: cellular_component def: "Any membrane that is part of an omegasome." [GO_REF:0000064, GOC:mf, GOC:TermGenie, PMID:18725538, PMID:24591649] is_a: GO:0098588 ! bounding membrane of organelle created_by: pr creation_date: 2014-08-19T12:33:09Z [Term] id: GO:1903350 name: response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] is_a: GO:0042493 ! response to drug is_a: GO:0060359 ! response to ammonium ion is_a: GO:0071869 ! response to catecholamine created_by: mr creation_date: 2014-08-19T19:33:26Z [Term] id: GO:1903351 name: cellular response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:1903350 ! response to dopamine created_by: mr creation_date: 2014-08-19T19:33:35Z [Term] id: GO:1903352 name: L-ornithine transmembrane transport namespace: biological_process def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015822 ! ornithine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr creation_date: 2014-08-20T13:01:38Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006997 ! nucleus organization relationship: regulates GO:0006997 ! nucleus organization created_by: hjd creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903354 name: regulation of distal tip cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097628 ! distal tip cell migration relationship: regulates GO:0097628 ! distal tip cell migration created_by: pr creation_date: 2014-08-21T10:05:08Z [Term] id: GO:1903355 name: negative regulation of distal tip cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] synonym: "down regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of distal tip cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1903354 ! regulation of distal tip cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097628 ! distal tip cell migration relationship: negatively_regulates GO:0097628 ! distal tip cell migration created_by: pr creation_date: 2014-08-21T10:05:17Z [Term] id: GO:1903356 name: positive regulation of distal tip cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] synonym: "activation of distal tip cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of distal tip cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of distal tip cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1903354 ! regulation of distal tip cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097628 ! distal tip cell migration relationship: positively_regulates GO:0097628 ! distal tip cell migration created_by: pr creation_date: 2014-08-21T10:05:26Z [Term] id: GO:1903357 name: regulation of transcription initiation from RNA polymerase I promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter." [GO_REF:0000058, GOC:TermGenie, PMID:9092673] synonym: "regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW [] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006361 ! transcription initiation from RNA polymerase I promoter relationship: regulates GO:0006361 ! transcription initiation from RNA polymerase I promoter created_by: mah creation_date: 2014-08-21T10:19:32Z [Term] id: GO:1903358 name: regulation of Golgi organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788] synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie] synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007030 ! Golgi organization relationship: regulates GO:0007030 ! Golgi organization created_by: als creation_date: 2014-08-21T10:22:22Z [Term] id: GO:1903359 name: lateral cortical node assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node." [GO_REF:0000079, GOC:TermGenie, PMID:25009287] synonym: "lateral cortical node formation" EXACT [GOC:TermGenie] synonym: "Skb1-containing cortical node assembly" EXACT [GOC:TermGenie] synonym: "Skb1-containing cortical node formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2014-08-21T10:22:51Z [Term] id: GO:1903360 name: protein localization to lateral cortical node namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node." [GO_REF:0000087, GOC:TermGenie, PMID:25009287] synonym: "protein localisation in lateral cortical node" EXACT [GOC:TermGenie] synonym: "protein localisation to lateral cortical node" EXACT [GOC:TermGenie] synonym: "protein localization in lateral cortical node" EXACT [GOC:TermGenie] is_a: GO:0072697 ! protein localization to cell cortex created_by: mah creation_date: 2014-08-21T10:23:00Z [Term] id: GO:1903361 name: protein localization to basolateral plasma membrane namespace: biological_process alt_id: GO:0061467 def: "Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351] synonym: "basolateral protein localization" EXACT [] synonym: "protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery created_by: dph creation_date: 2012-10-19T13:58:04Z [Term] id: GO:1903362 name: regulation of cellular protein catabolic process namespace: biological_process alt_id: GO:2000598 def: "Any process that modulates the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "regulation of cyclin catabolic process" NARROW [] synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "regulation of cyclin degradation" NARROW [GOC:obol] synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044257 ! cellular protein catabolic process relationship: regulates GO:0044257 ! cellular protein catabolic process created_by: kmv creation_date: 2014-08-21T15:05:45Z [Term] id: GO:1903363 name: negative regulation of cellular protein catabolic process namespace: biological_process alt_id: GO:2000599 def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "negative regulation of cyclin catabolic process" NARROW [] synonym: "negative regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "negative regulation of cyclin degradation" NARROW [GOC:obol] synonym: "negative regulation of degradation of cyclin" NARROW [GOC:obol] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044257 ! cellular protein catabolic process relationship: negatively_regulates GO:0044257 ! cellular protein catabolic process created_by: kmv creation_date: 2014-08-21T15:05:53Z [Term] id: GO:1903364 name: positive regulation of cellular protein catabolic process namespace: biological_process alt_id: GO:2000600 def: "Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "positive regulation of cyclin catabolic process" NARROW [] synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044257 ! cellular protein catabolic process relationship: positively_regulates GO:0044257 ! cellular protein catabolic process created_by: kmv creation_date: 2014-08-21T15:06:01Z [Term] id: GO:1903365 name: regulation of fear response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] synonym: "regulation of physiological fear response" EXACT [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042596 ! fear response relationship: regulates GO:0042596 ! fear response created_by: mr creation_date: 2014-08-21T23:21:36Z [Term] id: GO:1903366 name: negative regulation of fear response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] synonym: "down regulation of fear response" EXACT [GOC:TermGenie] synonym: "down regulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "down-regulation of fear response" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "downregulation of fear response" EXACT [GOC:TermGenie] synonym: "downregulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "inhibition of fear response" NARROW [GOC:TermGenie] synonym: "inhibition of physiological fear response" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological fear response" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903365 ! regulation of fear response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042596 ! fear response relationship: negatively_regulates GO:0042596 ! fear response created_by: mr creation_date: 2014-08-21T23:21:45Z [Term] id: GO:1903367 name: positive regulation of fear response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] synonym: "activation of fear response" NARROW [GOC:TermGenie] synonym: "activation of physiological fear response" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "up regulation of fear response" EXACT [GOC:TermGenie] synonym: "up regulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "up-regulation of fear response" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological fear response" EXACT [GOC:TermGenie] synonym: "upregulation of fear response" EXACT [GOC:TermGenie] synonym: "upregulation of physiological fear response" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903365 ! regulation of fear response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042596 ! fear response relationship: positively_regulates GO:0042596 ! fear response created_by: mr creation_date: 2014-08-21T23:21:53Z [Term] id: GO:1903368 name: regulation of foraging behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060756 ! foraging behavior relationship: regulates GO:0060756 ! foraging behavior created_by: mr creation_date: 2014-08-22T03:03:04Z [Term] id: GO:1903369 name: negative regulation of foraging behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] synonym: "down regulation of foraging behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of foraging behavior" EXACT [GOC:TermGenie] synonym: "downregulation of foraging behavior" EXACT [GOC:TermGenie] synonym: "inhibition of foraging behavior" NARROW [GOC:TermGenie] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1903368 ! regulation of foraging behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060756 ! foraging behavior relationship: negatively_regulates GO:0060756 ! foraging behavior created_by: mr creation_date: 2014-08-22T03:03:12Z [Term] id: GO:1903370 name: positive regulation of foraging behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] synonym: "activation of foraging behavior" NARROW [GOC:TermGenie] synonym: "up regulation of foraging behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of foraging behavior" EXACT [GOC:TermGenie] synonym: "upregulation of foraging behavior" EXACT [GOC:TermGenie] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1903368 ! regulation of foraging behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060756 ! foraging behavior relationship: positively_regulates GO:0060756 ! foraging behavior created_by: mr creation_date: 2014-08-22T03:03:20Z [Term] id: GO:1903371 name: regulation of endoplasmic reticulum tubular network organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] synonym: "regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "regulation of ER tubular network organization" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071786 ! endoplasmic reticulum tubular network organization relationship: regulates GO:0071786 ! endoplasmic reticulum tubular network organization created_by: als creation_date: 2014-08-22T11:01:14Z [Term] id: GO:1903372 name: negative regulation of endoplasmic reticulum tubular network organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] synonym: "down regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "down regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "down regulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "down-regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "downregulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "downregulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie] synonym: "inhibition of ER tubular network organisation" NARROW [GOC:TermGenie] synonym: "inhibition of ER tubular network organization" NARROW [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of ER tubular network organization" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization relationship: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization created_by: als creation_date: 2014-08-22T11:01:23Z [Term] id: GO:1903373 name: positive regulation of endoplasmic reticulum tubular network organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] synonym: "activation of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie] synonym: "activation of ER tubular network organisation" NARROW [GOC:TermGenie] synonym: "activation of ER tubular network organization" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "up regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "up regulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "up-regulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of ER tubular network organization" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] synonym: "upregulation of ER tubular network organisation" EXACT [GOC:TermGenie] synonym: "upregulation of ER tubular network organization" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization relationship: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization created_by: als creation_date: 2014-08-22T11:01:31Z [Term] id: GO:1903374 name: subarachnoid space development namespace: biological_process def: "The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure." [GO_REF:0000094, GOC:cjm, GOC:TermGenie, Wikipedia:Subarachnoid_space] synonym: "cavitas subarachnoidea development" RELATED [GOC:TermGenie] synonym: "cavum subarachnoideale development" RELATED [GOC:TermGenie] synonym: "spatium leptomeningeum development" RELATED [GOC:TermGenie] synonym: "spatium subarachnoideum development" RELATED [GOC:TermGenie] synonym: "subarachnoid cavity development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development created_by: pr creation_date: 2014-08-22T12:20:56Z [Term] id: GO:1903375 name: facioacoustic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "acoustico-facial VII-VIII ganglion complex development" EXACT [UBERON:0012175] synonym: "acousticofacial ganglion development" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion complex VII-VIII development" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion development" EXACT [GOC:TermGenie] synonym: "facio-acoustic VII-VIII ganglion complex development" EXACT [GOC:TermGenie] is_a: GO:0061550 ! cranial ganglion development created_by: bf creation_date: 2014-08-26T12:40:36Z [Term] id: GO:1903376 name: regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] synonym: "regulation of oxidative stress-induced neuron apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of oxidative stress-induced neuronal apoptosis" BROAD [GOC:TermGenie] is_a: GO:0043523 ! regulation of neuron apoptotic process is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress relationship: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress created_by: bf creation_date: 2014-08-26T13:03:13Z [Term] id: GO:1903377 name: negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595] synonym: "down regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] synonym: "negative regulation of oxidative stress-induced neuron apoptosis" EXACT [GOC:bf] synonym: "neuroprotection against oxidative stress-induced apoptosis" RELATED [GOC:bf] synonym: "protection against oxidative stress-induced neuron apoptosis" RELATED [GOC:bf] synonym: "protection against oxidative stress-induced neuronal apoptosis" RELATED [GOC:bf] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress relationship: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress created_by: bf creation_date: 2014-08-26T13:03:28Z [Term] id: GO:1903378 name: positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] synonym: "positive regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] synonym: "up regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] synonym: "upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903223 ! positive regulation of oxidative stress-induced neuron death is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress relationship: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress created_by: bf creation_date: 2014-08-26T13:03:36Z [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0060623 ! regulation of chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007076 ! mitotic chromosome condensation relationship: regulates GO:0007076 ! mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:13Z [Term] id: GO:1903380 name: positive regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:1903379 ! regulation of mitotic chromosome condensation is_a: GO:1905821 ! positive regulation of chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007076 ! mitotic chromosome condensation relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:29Z [Term] id: GO:1903381 name: regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of ER stress-induced neuron apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [] is_a: GO:0043523 ! regulation of neuron apoptotic process is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress created_by: bf creation_date: 2014-08-27T08:45:29Z [Term] id: GO:1903382 name: negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807] synonym: "down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903381 ! regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress relationship: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress created_by: bf creation_date: 2014-08-27T08:45:38Z [Term] id: GO:1903383 name: regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of H2O2-induced neuron apoptosis" BROAD [GOC:bf] synonym: "regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [] is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide created_by: bf creation_date: 2014-08-27T08:50:37Z [Term] id: GO:1903384 name: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939] synonym: "down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [] synonym: "protection against H2O2-induced neuron apoptosis" RELATED [GOC:bf] synonym: "protection against hydrogen peroxide-induced neuron apoptosis" RELATED [GOC:bf] is_a: GO:1903208 ! negative regulation of hydrogen peroxide-induced neuron death is_a: GO:1903377 ! negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway is_a: GO:1903383 ! regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway is_a: GO:1903751 ! negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide created_by: bf creation_date: 2014-08-27T08:50:45Z [Term] id: GO:1903385 name: regulation of homophilic cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules relationship: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules created_by: als creation_date: 2014-08-27T09:57:30Z [Term] id: GO:1903386 name: negative regulation of homophilic cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] synonym: "down regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of homophilic cell adhesion" EXACT [GOC:TermGenie] synonym: "inhibition of homophilic cell adhesion" NARROW [GOC:TermGenie] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:1903385 ! regulation of homophilic cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules relationship: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules created_by: als creation_date: 2014-08-27T09:57:38Z [Term] id: GO:1903387 name: positive regulation of homophilic cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] synonym: "activation of homophilic cell adhesion" NARROW [GOC:TermGenie] synonym: "up regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of homophilic cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:1903385 ! regulation of homophilic cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules relationship: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules created_by: als creation_date: 2014-08-27T09:57:46Z [Term] id: GO:1903388 name: regulation of synaptic vesicle uncoating namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] synonym: "regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016191 ! synaptic vesicle uncoating relationship: regulates GO:0016191 ! synaptic vesicle uncoating created_by: pad creation_date: 2014-08-27T10:02:53Z [Term] id: GO:1903389 name: negative regulation of synaptic vesicle uncoating namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] synonym: "down regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] synonym: "inhibition of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle uncoating" NARROW [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "negative regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] is_a: GO:1900243 ! negative regulation of synaptic vesicle endocytosis is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1903388 ! regulation of synaptic vesicle uncoating intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016191 ! synaptic vesicle uncoating relationship: negatively_regulates GO:0016191 ! synaptic vesicle uncoating created_by: pad creation_date: 2014-08-27T10:03:02Z [Term] id: GO:1903390 name: positive regulation of synaptic vesicle uncoating namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] synonym: "activation of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle uncoating" NARROW [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "positive regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] is_a: GO:1900244 ! positive regulation of synaptic vesicle endocytosis is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1903388 ! regulation of synaptic vesicle uncoating intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016191 ! synaptic vesicle uncoating relationship: positively_regulates GO:0016191 ! synaptic vesicle uncoating created_by: pad creation_date: 2014-08-27T10:03:10Z [Term] id: GO:1903391 name: regulation of adherens junction organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] synonym: "regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "regulation of adherens junction organisation" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034332 ! adherens junction organization relationship: regulates GO:0034332 ! adherens junction organization created_by: als creation_date: 2014-08-27T10:08:38Z [Term] id: GO:1903392 name: negative regulation of adherens junction organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] synonym: "down regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "down regulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "down regulation of adherens junction organization" EXACT [GOC:TermGenie] synonym: "down-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of adherens junction organization" EXACT [GOC:TermGenie] synonym: "downregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "downregulation of adherens junction organization" EXACT [GOC:TermGenie] synonym: "inhibition of adherens junction assembly and maintenance" NARROW [GOC:TermGenie] synonym: "inhibition of adherens junction organisation" NARROW [GOC:TermGenie] synonym: "inhibition of adherens junction organization" NARROW [GOC:TermGenie] synonym: "negative regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "negative regulation of adherens junction organisation" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903391 ! regulation of adherens junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034332 ! adherens junction organization relationship: negatively_regulates GO:0034332 ! adherens junction organization created_by: als creation_date: 2014-08-27T10:08:47Z [Term] id: GO:1903393 name: positive regulation of adherens junction organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] synonym: "activation of adherens junction assembly and maintenance" NARROW [GOC:TermGenie] synonym: "activation of adherens junction organisation" NARROW [GOC:TermGenie] synonym: "activation of adherens junction organization" NARROW [GOC:TermGenie] synonym: "positive regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "positive regulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "up regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "up regulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "up regulation of adherens junction organization" EXACT [GOC:TermGenie] synonym: "up-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of adherens junction organization" EXACT [GOC:TermGenie] synonym: "upregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of adherens junction organisation" EXACT [GOC:TermGenie] synonym: "upregulation of adherens junction organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903391 ! regulation of adherens junction organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0034332 ! adherens junction organization relationship: positively_regulates GO:0034332 ! adherens junction organization created_by: als creation_date: 2014-08-27T10:08:55Z [Term] id: GO:1903394 name: protein localization to kinetochore involved in kinetochore assembly namespace: biological_process def: "Any protein localization to kinetochore that is involved in kinetochore assembly." [GO_REF:0000060, GOC:TermGenie, PMID:15369671] synonym: "condensin localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "condensin localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "condensin localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "condensin localization to kinetochore involved in kinetochore assembly" NARROW [GOC:TermGenie] synonym: "condensin localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] synonym: "protein localisation to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "protein localisation to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "protein localisation to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "protein localisation to kinetochore involved in kinetochore assembly" EXACT [GOC:TermGenie] synonym: "protein localisation to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] synonym: "protein localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "protein localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "protein localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "protein localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] is_a: GO:0034501 ! protein localization to kinetochore intersection_of: GO:0034501 ! protein localization to kinetochore intersection_of: part_of GO:0051382 ! kinetochore assembly relationship: part_of GO:0051382 ! kinetochore assembly created_by: vw creation_date: 2014-08-29T13:11:55Z [Term] id: GO:1903395 name: regulation of secondary cell septum biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] is_a: GO:0140279 ! regulation of mitotic division septum assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1990344 ! secondary cell septum biogenesis relationship: regulates GO:1990344 ! secondary cell septum biogenesis created_by: di creation_date: 2014-08-29T21:42:17Z [Term] id: GO:1903396 name: negative regulation of secondary cell septum biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] synonym: "down regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of secondary cell septum biogenesis" NARROW [GOC:TermGenie] is_a: GO:0140280 ! negative regulation of mitotic division septum assembly is_a: GO:1903395 ! regulation of secondary cell septum biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990344 ! secondary cell septum biogenesis relationship: negatively_regulates GO:1990344 ! secondary cell septum biogenesis created_by: di creation_date: 2014-08-29T21:42:26Z [Term] id: GO:1903397 name: positive regulation of secondary cell septum biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] synonym: "activation of secondary cell septum biogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] is_a: GO:0140281 ! positive regulation of mitotic division septum assembly is_a: GO:1903395 ! regulation of secondary cell septum biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990344 ! secondary cell septum biogenesis relationship: positively_regulates GO:1990344 ! secondary cell septum biogenesis created_by: di creation_date: 2014-08-29T21:42:34Z [Term] id: GO:1903398 name: regulation of m7G(5')pppN diphosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] synonym: "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity created_by: mah creation_date: 2014-09-01T10:16:40Z [Term] id: GO:1903399 name: positive regulation of m7G(5')pppN diphosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] synonym: "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of decapase activity" RELATED [GOC:TermGenie] synonym: "activation of M(7)G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of m7G(5')pppN diphosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of m7G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "up regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of decapase activity" RELATED [GOC:TermGenie] synonym: "upregulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903398 ! regulation of m7G(5')pppN diphosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity created_by: mah creation_date: 2014-09-01T10:16:49Z [Term] id: GO:1903400 name: L-arginine transmembrane transport namespace: biological_process def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1902023 ! L-arginine transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903826 ! arginine transmembrane transport created_by: pr creation_date: 2014-09-01T13:45:48Z [Term] id: GO:1903401 name: L-lysine transmembrane transport namespace: biological_process def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902022 ! L-lysine transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr creation_date: 2014-09-01T13:45:56Z [Term] id: GO:1903402 name: regulation of renal phosphate excretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] synonym: "regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] is_a: GO:0044062 ! regulation of excretion is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044722 ! renal phosphate excretion relationship: regulates GO:0044722 ! renal phosphate excretion created_by: pm creation_date: 2014-09-01T13:47:01Z [Term] id: GO:1903403 name: negative regulation of renal phosphate excretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] synonym: "down regulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "down regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "down-regulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "down-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "downregulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "downregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "inhibition of renal phosphate excretion" NARROW [GOC:TermGenie] synonym: "inhibition of renal phosphate ion excretion" NARROW [GOC:TermGenie] synonym: "negative regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903402 ! regulation of renal phosphate excretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044722 ! renal phosphate excretion relationship: negatively_regulates GO:0044722 ! renal phosphate excretion created_by: pm creation_date: 2014-09-01T13:47:10Z [Term] id: GO:1903404 name: positive regulation of renal phosphate excretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] synonym: "activation of renal phosphate excretion" NARROW [GOC:TermGenie] synonym: "activation of renal phosphate ion excretion" NARROW [GOC:TermGenie] synonym: "positive regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "up regulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "up regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "up-regulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "up-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] synonym: "upregulation of renal phosphate excretion" EXACT [GOC:TermGenie] synonym: "upregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903402 ! regulation of renal phosphate excretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044722 ! renal phosphate excretion relationship: positively_regulates GO:0044722 ! renal phosphate excretion created_by: pm creation_date: 2014-09-01T13:47:18Z [Term] id: GO:1903405 name: protein localization to nuclear body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] synonym: "protein localisation in nuclear body" EXACT [GOC:TermGenie] synonym: "protein localisation to nuclear body" EXACT [GOC:TermGenie] synonym: "protein localization in nuclear body" EXACT [GOC:TermGenie] is_a: GO:1990173 ! protein localization to nucleoplasm created_by: mah creation_date: 2014-09-01T13:57:11Z [Term] id: GO:1903406 name: regulation of sodium:potassium-exchanging ATPase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] synonym: "regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "regulation of sodium pump" BROAD [GOC:TermGenie] synonym: "regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity relationship: regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity created_by: mr creation_date: 2014-09-02T19:45:08Z [Term] id: GO:1903407 name: negative regulation of sodium:potassium-exchanging ATPase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] synonym: "down regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "down regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "down regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "down regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "down-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "down-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "down-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "downregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "downregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "downregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie] synonym: "inhibition of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "inhibition of Na+,K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na+/K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na,K-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of Na,K-pump" RELATED [GOC:TermGenie] synonym: "inhibition of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "negative regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "negative regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "negative regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity is_a: GO:1903406 ! regulation of sodium:potassium-exchanging ATPase activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity relationship: negatively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity created_by: mr creation_date: 2014-09-02T19:45:16Z [Term] id: GO:1903408 name: positive regulation of sodium:potassium-exchanging ATPase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] synonym: "activation of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie] synonym: "activation of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "activation of Na+,K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na+/K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na,K-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "activation of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "positive regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "positive regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "positive regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "up regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "up regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "up regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "up-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "up-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "up-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "upregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na+,K+ pump" RELATED [GOC:TermGenie] synonym: "upregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of Na,K-pump" RELATED [GOC:TermGenie] synonym: "upregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity is_a: GO:1903406 ! regulation of sodium:potassium-exchanging ATPase activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity relationship: positively_regulates GO:0005391 ! sodium:potassium-exchanging ATPase activity created_by: mr creation_date: 2014-09-02T19:45:24Z [Term] id: GO:1903409 name: reactive oxygen species biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "reactive oxygen species generation" RELATED [PMID:24252804] synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "ROS formation" RELATED [] synonym: "ROS generation" RELATED [PMID:24252804] is_a: GO:0009058 ! biosynthetic process is_a: GO:0072593 ! reactive oxygen species metabolic process created_by: bf creation_date: 2014-09-03T09:19:13Z [Term] id: GO:1903412 name: response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound created_by: rl creation_date: 2014-09-03T12:45:43Z [Term] id: GO:1903413 name: cellular response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903412 ! response to bile acid created_by: rl creation_date: 2014-09-03T12:45:51Z [Term] id: GO:1903415 name: flavonoid transport from endoplasmic reticulum to plant-type vacuole namespace: biological_process def: "The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole." [GO_REF:0000078, GOC:tb, GOC:TermGenie, PMID:25116949] synonym: "flavonoid accumulation in vacuole" RELATED [] is_a: GO:0007034 ! vacuolar transport is_a: GO:0071702 ! organic substance transport created_by: tb creation_date: 2014-09-05T00:35:34Z [Term] id: GO:1903416 name: response to glycoside namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus." [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970] synonym: "cellular response to ouabain" RELATED [CHEBI:472805] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: rl creation_date: 2014-09-05T12:41:01Z [Term] id: GO:1903418 name: protein localization to plasma membrane of cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:25157670, PMID:27852900] synonym: "protein localisation in plasma membrane of cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to plasma membrane of cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in plasma membrane of cell tip" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990151 ! protein localization to cell tip is_a: GO:1990778 ! protein localization to cell periphery created_by: mah creation_date: 2014-09-08T15:08:51Z [Term] id: GO:1903419 name: protein localization to cortical endoplasmic reticulum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum." [GO_REF:0000087, GOC:TermGenie, PMID:25103238] synonym: "protein localisation in cortical endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "protein localisation to cortical endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "protein localization in cortical endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "protein localization to cortical ER" EXACT [] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:1903420 ! protein localization to endoplasmic reticulum tubular network created_by: mah creation_date: 2014-09-08T16:03:28Z [Term] id: GO:1903420 name: protein localization to endoplasmic reticulum tubular network namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network." [GO_REF:0000087, GOC:TermGenie, PMID:25103238] synonym: "protein localisation in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localisation to endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localization in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localization to tubular ER" RELATED [PMID:25103238] is_a: GO:0070972 ! protein localization to endoplasmic reticulum created_by: mah creation_date: 2014-09-08T16:03:37Z [Term] id: GO:1903421 name: regulation of synaptic vesicle recycling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype synonym: "regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] is_a: GO:0098693 ! regulation of synaptic vesicle cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036465 ! synaptic vesicle recycling relationship: regulates GO:0036465 ! synaptic vesicle recycling created_by: pad creation_date: 2014-09-09T15:27:50Z [Term] id: GO:1903422 name: negative regulation of synaptic vesicle recycling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype synonym: "down regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "down regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "down regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] synonym: "down-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "down-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "down-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] synonym: "downregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "downregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "downregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] synonym: "inhibition of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "inhibition of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "negative regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "negative regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1903421 ! regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036465 ! synaptic vesicle recycling relationship: negatively_regulates GO:0036465 ! synaptic vesicle recycling created_by: pad creation_date: 2014-09-09T15:27:59Z [Term] id: GO:1903423 name: positive regulation of synaptic vesicle recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype synonym: "activation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "activation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "activation of synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "positive regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "positive regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "up regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "up regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "up regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] synonym: "up-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "up-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "up-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] synonym: "upregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "upregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] synonym: "upregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1903421 ! regulation of synaptic vesicle recycling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036465 ! synaptic vesicle recycling relationship: positively_regulates GO:0036465 ! synaptic vesicle recycling created_by: pad creation_date: 2014-09-09T15:28:07Z [Term] id: GO:1903424 name: fluoride transmembrane transport namespace: biological_process def: "The process in which fluoride is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24173035] synonym: "fluoride membrane transport" EXACT [] synonym: "transmembrane fluoride transport" EXACT [] is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: mcc creation_date: 2014-09-09T21:21:01Z [Term] id: GO:1903425 name: fluoride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fluoride from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:24173035] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:1903424 ! fluoride transmembrane transport created_by: mcc creation_date: 2014-09-09T21:27:55Z [Term] id: GO:1903426 name: regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "regulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903409 ! reactive oxygen species biosynthetic process relationship: regulates GO:1903409 ! reactive oxygen species biosynthetic process created_by: bf creation_date: 2014-09-11T10:01:47Z [Term] id: GO:1903427 name: negative regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie] synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "prevention of ROS generation" EXACT [PMID:24252804] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process relationship: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process created_by: bf creation_date: 2014-09-11T10:01:56Z [Term] id: GO:1903428 name: positive regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "activation of ROS formation" RELATED [GOC:TermGenie] synonym: "activation of ROS generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process relationship: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process created_by: bf creation_date: 2014-09-11T10:02:05Z [Term] id: GO:1903429 name: regulation of cell maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048469 ! cell maturation relationship: regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:23Z [Term] id: GO:1903430 name: negative regulation of cell maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048469 ! cell maturation relationship: negatively_regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:32Z [Term] id: GO:1903431 name: positive regulation of cell maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "activation of cell maturation" NARROW [GOC:TermGenie] synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048469 ! cell maturation relationship: positively_regulates GO:0048469 ! cell maturation created_by: jl creation_date: 2014-09-15T13:31:41Z [Term] id: GO:1903432 name: regulation of TORC1 signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie] synonym: "regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] is_a: GO:0032006 ! regulation of TOR signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038202 ! TORC1 signaling relationship: regulates GO:0038202 ! TORC1 signaling created_by: jl creation_date: 2014-09-15T13:35:39Z [Term] id: GO:1903433 name: regulation of constitutive secretory pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045054 ! constitutive secretory pathway relationship: regulates GO:0045054 ! constitutive secretory pathway created_by: als creation_date: 2014-09-15T15:07:31Z [Term] id: GO:1903434 name: negative regulation of constitutive secretory pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] synonym: "down regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of constitutive secretory pathway" EXACT [GOC:TermGenie] synonym: "inhibition of constitutive secretory pathway" NARROW [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903433 ! regulation of constitutive secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045054 ! constitutive secretory pathway relationship: negatively_regulates GO:0045054 ! constitutive secretory pathway created_by: als creation_date: 2014-09-15T15:07:40Z [Term] id: GO:1903435 name: positive regulation of constitutive secretory pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] synonym: "activation of constitutive secretory pathway" NARROW [GOC:TermGenie] synonym: "up regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of constitutive secretory pathway" EXACT [GOC:TermGenie] is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903433 ! regulation of constitutive secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045054 ! constitutive secretory pathway relationship: positively_regulates GO:0045054 ! constitutive secretory pathway created_by: als creation_date: 2014-09-15T15:07:48Z [Term] id: GO:1903436 name: regulation of mitotic cytokinetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:1902412 ! regulation of mitotic cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902410 ! mitotic cytokinetic process relationship: regulates GO:1902410 ! mitotic cytokinetic process created_by: tb creation_date: 2014-09-15T23:11:38Z [Term] id: GO:1903437 name: negative regulation of mitotic cytokinetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic cytokinetic process" NARROW [GOC:TermGenie] is_a: GO:1902413 ! negative regulation of mitotic cytokinesis is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902410 ! mitotic cytokinetic process relationship: negatively_regulates GO:1902410 ! mitotic cytokinetic process created_by: tb creation_date: 2014-09-15T23:11:47Z [Term] id: GO:1903438 name: positive regulation of mitotic cytokinetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of mitotic cytokinetic process" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] is_a: GO:1903436 ! regulation of mitotic cytokinetic process is_a: GO:1903490 ! positive regulation of mitotic cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902410 ! mitotic cytokinetic process relationship: positively_regulates GO:1902410 ! mitotic cytokinetic process created_by: tb creation_date: 2014-09-15T23:11:55Z [Term] id: GO:1903439 name: calcitonin family receptor complex namespace: cellular_component def: "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:0097648 ! G protein-coupled receptor complex created_by: pr creation_date: 2014-09-16T13:25:11Z [Term] id: GO:1903440 name: amylin receptor complex namespace: cellular_component def: "A protein complex which is capable of amylin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416] is_a: GO:1903439 ! calcitonin family receptor complex created_by: pr creation_date: 2014-09-16T13:25:20Z [Term] id: GO:1903441 name: protein localization to ciliary membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery created_by: pr creation_date: 2014-09-16T15:15:39Z [Term] id: GO:1903442 name: response to lipoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0070542 ! response to fatty acid created_by: jl creation_date: 2014-09-17T13:52:03Z [Term] id: GO:1903443 name: cellular response to lipoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1903442 ! response to lipoic acid created_by: jl creation_date: 2014-09-17T13:52:12Z [Term] id: GO:1903444 name: negative regulation of brown fat cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23977283] synonym: "down regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of brown fat cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of brown adipocyte cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of brown adipocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of brown fat cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:0045599 ! negative regulation of fat cell differentiation is_a: GO:0090335 ! regulation of brown fat cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050873 ! brown fat cell differentiation relationship: negatively_regulates GO:0050873 ! brown fat cell differentiation created_by: hjd creation_date: 2014-09-17T19:15:00Z [Term] id: GO:1903445 name: protein transport from ciliary membrane to plasma membrane namespace: biological_process def: "The directed movement of protein from ciliary membrane to plasma membrane." [GO_REF:0000078, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] is_a: GO:0032594 ! protein transport within lipid bilayer is_a: GO:0061951 ! establishment of protein localization to plasma membrane created_by: pr creation_date: 2014-09-18T07:46:10Z [Term] id: GO:1903446 name: geraniol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] synonym: "geraniol metabolism" EXACT [GOC:TermGenie] is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process created_by: di creation_date: 2014-09-19T08:18:34Z [Term] id: GO:1903447 name: geraniol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] synonym: "geraniol breakdown" EXACT [GOC:TermGenie] synonym: "geraniol catabolism" EXACT [GOC:TermGenie] synonym: "geraniol degradation" EXACT [GOC:TermGenie] is_a: GO:0016095 ! polyprenol catabolic process is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:1903446 ! geraniol metabolic process created_by: di creation_date: 2014-09-19T08:18:44Z [Term] id: GO:1903448 name: geraniol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] synonym: "geraniol anabolism" EXACT [GOC:TermGenie] synonym: "geraniol biosynthesis" EXACT [GOC:TermGenie] synonym: "geraniol formation" EXACT [GOC:TermGenie] synonym: "geraniol synthesis" EXACT [GOC:TermGenie] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0016099 ! monoterpenoid biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:1903446 ! geraniol metabolic process created_by: di creation_date: 2014-09-19T08:18:52Z [Term] id: GO:1903449 name: androst-4-ene-3,17-dione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione." [GO_REF:0000068, GOC:mr, GOC:TermGenie, PMID:2028480, PMID:4149619] synonym: "androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "androstenedione biosynthetic process" EXACT [] is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0120178 ! steroid hormone biosynthetic process created_by: mr creation_date: 2014-09-19T20:18:19Z [Term] id: GO:1903450 name: regulation of G1 to G0 transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] synonym: "regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "regulation of stationary phase" RELATED [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070314 ! G1 to G0 transition relationship: regulates GO:0070314 ! G1 to G0 transition created_by: di creation_date: 2014-09-19T22:23:13Z [Term] id: GO:1903451 name: negative regulation of G1 to G0 transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] synonym: "down regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "down regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "down regulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "down regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "down regulation of stationary phase" RELATED [GOC:TermGenie] synonym: "down-regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "down-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "down-regulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "down-regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "down-regulation of stationary phase" RELATED [GOC:TermGenie] synonym: "downregulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "downregulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "downregulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "downregulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "downregulation of stationary phase" RELATED [GOC:TermGenie] synonym: "inhibition of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "inhibition of establishment of cell quiescence" NARROW [GOC:TermGenie] synonym: "inhibition of G1 to G0 transition" NARROW [GOC:TermGenie] synonym: "inhibition of G1/G0 transition" NARROW [GOC:TermGenie] synonym: "inhibition of stationary phase" RELATED [GOC:TermGenie] synonym: "negative regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "negative regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "negative regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "negative regulation of stationary phase" RELATED [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1903450 ! regulation of G1 to G0 transition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070314 ! G1 to G0 transition relationship: negatively_regulates GO:0070314 ! G1 to G0 transition created_by: di creation_date: 2014-09-19T22:23:22Z [Term] id: GO:1903452 name: positive regulation of G1 to G0 transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] synonym: "activation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "activation of establishment of cell quiescence" NARROW [GOC:TermGenie] synonym: "activation of G1 to G0 transition" NARROW [GOC:TermGenie] synonym: "activation of G1/G0 transition" NARROW [GOC:TermGenie] synonym: "activation of stationary phase" RELATED [GOC:TermGenie] synonym: "positive regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "positive regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "positive regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "positive regulation of stationary phase" RELATED [GOC:TermGenie] synonym: "up regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "up regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "up regulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "up regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "up regulation of stationary phase" RELATED [GOC:TermGenie] synonym: "up-regulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "up-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "up-regulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "up-regulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "up-regulation of stationary phase" RELATED [GOC:TermGenie] synonym: "upregulation of cell cycle quiescence" RELATED [GOC:TermGenie] synonym: "upregulation of establishment of cell quiescence" EXACT [GOC:TermGenie] synonym: "upregulation of G1 to G0 transition" EXACT [GOC:TermGenie] synonym: "upregulation of G1/G0 transition" EXACT [GOC:TermGenie] synonym: "upregulation of stationary phase" RELATED [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903450 ! regulation of G1 to G0 transition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070314 ! G1 to G0 transition relationship: positively_regulates GO:0070314 ! G1 to G0 transition created_by: di creation_date: 2014-09-19T22:23:30Z [Term] id: GO:1903453 name: RNA interference involved in olfactory learning namespace: biological_process def: "Any RNA interference that is involved in olfactory learning." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:23993094] synonym: "posttranscriptional gene silencing by siRNA involved in olfactory learning" EXACT [GOC:TermGenie] synonym: "RNAi involved in olfactory learning" EXACT [GOC:TermGenie] is_a: GO:0016246 ! RNA interference intersection_of: GO:0016246 ! RNA interference intersection_of: part_of GO:0008355 ! olfactory learning relationship: part_of GO:0008355 ! olfactory learning created_by: kmv creation_date: 2014-09-22T13:50:09Z [Term] id: GO:1903454 name: regulation of androst-4-ene-3,17-dione biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] synonym: "regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process relationship: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process created_by: mr creation_date: 2014-09-22T14:36:50Z [Term] id: GO:1903455 name: negative regulation of androst-4-ene-3,17-dione biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] synonym: "down regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "down regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "down-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "downregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie] synonym: "inhibition of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of androstenedione" NARROW [GOC:TermGenie] synonym: "negative regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process relationship: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process created_by: mr creation_date: 2014-09-22T14:36:59Z [Term] id: GO:1903456 name: positive regulation of androst-4-ene-3,17-dione biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] synonym: "activation of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie] synonym: "activation of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie] synonym: "activation of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie] synonym: "activation of androstenedione" NARROW [GOC:TermGenie] synonym: "positive regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "positive regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "up regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "up-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process relationship: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process created_by: mr creation_date: 2014-09-22T14:37:07Z [Term] id: GO:1903457 name: lactate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775] synonym: "lactate breakdown" EXACT [GOC:TermGenie] synonym: "lactate catabolism" EXACT [GOC:TermGenie] synonym: "lactate degradation" EXACT [GOC:TermGenie] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process created_by: pr creation_date: 2014-09-23T08:41:03Z [Term] id: GO:1903459 name: mitotic DNA replication lagging strand elongation namespace: biological_process def: "Any lagging strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "lagging strand elongation involved in mitotic DNA replication" EXACT [] synonym: "lagging strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0006273 ! lagging strand elongation is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication intersection_of: GO:0006273 ! lagging strand elongation intersection_of: part_of GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:32:54Z [Term] id: GO:1903460 name: mitotic DNA replication leading strand elongation namespace: biological_process def: "Any leading strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "leading strand elongation involved in mitotic DNA replication" EXACT [] synonym: "leading strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0006272 ! leading strand elongation is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication intersection_of: GO:0006272 ! leading strand elongation intersection_of: part_of GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:33:03Z [Term] id: GO:1903461 name: Okazaki fragment processing involved in mitotic DNA replication namespace: biological_process def: "Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0033567 ! DNA replication, Okazaki fragment processing is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0033567 ! DNA replication, Okazaki fragment processing intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:33:11Z [Term] id: GO:1903463 name: regulation of mitotic cell cycle DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902969 ! mitotic DNA replication relationship: regulates GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:38:25Z [Term] id: GO:1903464 name: negative regulation of mitotic cell cycle DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "down regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902969 ! mitotic DNA replication relationship: negatively_regulates GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:38:33Z [Term] id: GO:1903465 name: positive regulation of mitotic cell cycle DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "activation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "activation of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "activation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "positive regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "positive regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "upregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "upregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902969 ! mitotic DNA replication relationship: positively_regulates GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:38:41Z [Term] id: GO:1903466 name: regulation of mitotic DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902975 ! mitotic DNA replication initiation relationship: regulates GO:1902975 ! mitotic DNA replication initiation created_by: vw creation_date: 2014-09-23T13:38:49Z [Term] id: GO:1903467 name: negative regulation of mitotic DNA replication initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication is_a: GO:1903466 ! regulation of mitotic DNA replication initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902975 ! mitotic DNA replication initiation relationship: negatively_regulates GO:1902975 ! mitotic DNA replication initiation created_by: vw creation_date: 2014-09-23T13:38:58Z [Term] id: GO:1903468 name: positive regulation of DNA replication initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "activation of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "activation of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "upregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation is_a: GO:1903465 ! positive regulation of mitotic cell cycle DNA replication is_a: GO:1903466 ! regulation of mitotic DNA replication initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902975 ! mitotic DNA replication initiation relationship: positively_regulates GO:1902975 ! mitotic DNA replication initiation created_by: vw creation_date: 2014-09-23T13:39:06Z [Term] id: GO:1903469 name: removal of RNA primer involved in mitotic DNA replication namespace: biological_process def: "Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0043137 ! DNA replication, removal of RNA primer is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0043137 ! DNA replication, removal of RNA primer intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: vw creation_date: 2014-09-23T13:42:24Z [Term] id: GO:1903470 name: obsolete actomyosin contractile ring assembly involved in mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any actomyosin contractile ring assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "constriction ring assembly involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, actomyosin contractile ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "cytokinesis, actomyosin ring biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "cytokinesis, actomyosin ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "cytokinesis, contractile ring assembly involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_obsolete: true created_by: vw creation_date: 2014-09-23T14:06:50Z [Term] id: GO:1903471 name: regulation of mitotic actomyosin contractile ring contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: vw creation_date: 2014-09-23T14:10:22Z [Term] id: GO:1903472 name: negative regulation of mitotic actomyosin contractile ring contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] synonym: "downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] synonym: "inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie] synonym: "negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: vw creation_date: 2014-09-23T14:10:38Z [Term] id: GO:1903473 name: positive regulation of mitotic actomyosin contractile ring contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie] synonym: "positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] synonym: "upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: vw creation_date: 2014-09-23T14:10:46Z [Term] id: GO:1903474 name: anchoring of the mitotic actomyosin contractile ring to the plasma membrane namespace: biological_process def: "A process that maintains the mitotic actinomyosin contractile ring at the plasma membrane." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:19139265, PMID:28784611] synonym: "cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0032189 ! maintenance of actomyosin contractile ring localization is_a: GO:1902405 ! mitotic actomyosin contractile ring localization intersection_of: GO:0032189 ! maintenance of actomyosin contractile ring localization intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007016 ! cytoskeletal anchoring at plasma membrane created_by: vw creation_date: 2014-09-23T14:12:48Z [Term] id: GO:1903475 name: mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0000915 ! actomyosin contractile ring assembly is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis intersection_of: GO:0000915 ! actomyosin contractile ring assembly intersection_of: part_of GO:0000281 ! mitotic cytokinesis created_by: vw creation_date: 2014-09-23T14:42:12Z [Term] id: GO:1903476 name: protein localization to cell division site involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] is_a: GO:1902575 ! protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0072741 ! protein localization to cell division site intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2014-09-23T14:52:37Z [Term] id: GO:1903477 name: mitotic contractile ring actin filament bundle assembly namespace: biological_process def: "Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw] synonym: "actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly" EXACT [] is_a: GO:0071519 ! actomyosin contractile ring actin filament bundle assembly is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization intersection_of: GO:0051017 ! actin filament bundle assembly intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2014-09-23T14:56:01Z [Term] id: GO:1903478 name: actin filament bundle convergence involved in mitotic contractile ring assembly namespace: biological_process def: "Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw] synonym: "actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly" EXACT [] is_a: GO:0071520 ! actomyosin contractile ring assembly actin filament bundle convergence is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization intersection_of: GO:0090426 ! actin filament bundle convergence intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2014-09-23T15:03:11Z [Term] id: GO:1903479 name: mitotic actomyosin contractile ring assembly actin filament organization namespace: biological_process def: "Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [] is_a: GO:1903047 ! mitotic cell cycle process is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization intersection_of: GO:0007015 ! actin filament organization intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2014-09-23T15:03:19Z [Term] id: GO:1903480 name: regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] is_a: GO:1903117 ! regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization relationship: regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization created_by: vw creation_date: 2014-09-23T16:03:42Z [Term] id: GO:1903481 name: negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization relationship: negatively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization created_by: vw creation_date: 2014-09-23T16:03:50Z [Term] id: GO:1903482 name: positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "activation of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly is_a: GO:1903501 ! positive regulation of mitotic actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization relationship: positively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization created_by: vw creation_date: 2014-09-23T16:03:59Z [Term] id: GO:1903483 name: regulation of maintenance of mitotic actomyosin contractile ring localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0065008 ! regulation of biological quality is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902471 ! regulation of mitotic actomyosin contractile ring localization is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane relationship: regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane created_by: vw creation_date: 2014-09-23T16:12:19Z [Term] id: GO:1903484 name: negative regulation of maintenance of mitotic actomyosin contractile ring localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "inhibition of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1901649 ! negative regulation of actomyosin contractile ring localization is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process is_a: GO:1903483 ! regulation of maintenance of mitotic actomyosin contractile ring localization is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane relationship: negatively_regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane created_by: vw creation_date: 2014-09-23T16:12:28Z [Term] id: GO:1903485 name: positive regulation of maintenance of mitotic actomyosin contractile ring localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "activation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "activation of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie] synonym: "positive regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "positive regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "upregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "upregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1901650 ! positive regulation of actomyosin contractile ring localization is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process is_a: GO:1903483 ! regulation of maintenance of mitotic actomyosin contractile ring localization is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane relationship: positively_regulates GO:1903474 ! anchoring of the mitotic actomyosin contractile ring to the plasma membrane created_by: vw creation_date: 2014-09-23T16:12:37Z [Term] id: GO:1903486 name: establishment of mitotic actomyosin contractile ring localization namespace: biological_process def: "Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "establishment of actomyosin contractile ring localization involved in mitotic cell cycle" EXACT [] is_a: GO:0032188 ! establishment of actomyosin contractile ring localization is_a: GO:1902405 ! mitotic actomyosin contractile ring localization intersection_of: GO:0032188 ! establishment of actomyosin contractile ring localization intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: vw creation_date: 2014-09-23T16:17:09Z [Term] id: GO:1903487 name: regulation of lactation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051046 ! regulation of secretion is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007595 ! lactation relationship: regulates GO:0007595 ! lactation created_by: mr creation_date: 2014-09-24T14:44:13Z [Term] id: GO:1903488 name: negative regulation of lactation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] synonym: "down regulation of lactation" EXACT [GOC:TermGenie] synonym: "down-regulation of lactation" EXACT [GOC:TermGenie] synonym: "downregulation of lactation" EXACT [GOC:TermGenie] synonym: "inhibition of lactation" NARROW [GOC:TermGenie] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903487 ! regulation of lactation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007595 ! lactation relationship: negatively_regulates GO:0007595 ! lactation created_by: mr creation_date: 2014-09-24T14:44:22Z [Term] id: GO:1903489 name: positive regulation of lactation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] synonym: "activation of lactation" NARROW [GOC:TermGenie] synonym: "up regulation of lactation" EXACT [GOC:TermGenie] synonym: "up-regulation of lactation" EXACT [GOC:TermGenie] synonym: "upregulation of lactation" EXACT [GOC:TermGenie] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903487 ! regulation of lactation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007595 ! lactation relationship: positively_regulates GO:0007595 ! lactation created_by: mr creation_date: 2014-09-24T14:44:30Z [Term] id: GO:1903490 name: positive regulation of mitotic cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:24920823] synonym: "activation of cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "activation of mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "positive regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1902412 ! regulation of mitotic cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000281 ! mitotic cytokinesis relationship: positively_regulates GO:0000281 ! mitotic cytokinesis created_by: al creation_date: 2014-09-25T09:00:35Z [Term] id: GO:1903491 name: response to simvastatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0036273 ! response to statin created_by: hp creation_date: 2014-09-25T10:58:06Z [Term] id: GO:1903492 name: response to acetylsalicylate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T10:58:23Z [Term] id: GO:1903493 name: response to clopidogrel namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061476 ! response to anticoagulant is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T11:36:42Z [Term] id: GO:1903494 name: response to dehydroepiandrosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: mr creation_date: 2014-09-25T17:01:18Z [Term] id: GO:1903495 name: cellular response to dehydroepiandrosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone is_a: GO:1903494 ! response to dehydroepiandrosterone created_by: mr creation_date: 2014-09-25T17:01:26Z [Term] id: GO:1903496 name: response to 11-deoxycorticosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: mr creation_date: 2014-09-25T17:01:35Z [Term] id: GO:1903497 name: cellular response to 11-deoxycorticosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone is_a: GO:1903496 ! response to 11-deoxycorticosterone created_by: mr creation_date: 2014-09-25T17:01:43Z [Term] id: GO:1903498 name: bundle sheath cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell." [GO_REF:0000086, GOC:tb, GOC:TermGenie, PMID:24517883] is_a: GO:0030154 ! cell differentiation created_by: tb creation_date: 2014-09-26T01:31:04Z [Term] id: GO:1903499 name: regulation of mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] synonym: "regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] is_a: GO:1903436 ! regulation of mitotic cytokinetic process is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly relationship: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: pr creation_date: 2014-09-30T10:13:50Z [Term] id: GO:1903500 name: negative regulation of mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] synonym: "down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "inhibition of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "negative regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly is_a: GO:2000432 ! negative regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly relationship: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: pr creation_date: 2014-09-30T10:13:59Z [Term] id: GO:1903501 name: positive regulation of mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] synonym: "activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie] synonym: "activation of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] synonym: "activation of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] synonym: "up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] synonym: "upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly is_a: GO:2000433 ! positive regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly relationship: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: pr creation_date: 2014-09-30T10:14:07Z [Term] id: GO:1903502 name: translation repressor complex namespace: cellular_component def: "A protein complex which is capable of translation repressor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:14723848] comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-09-30T12:44:27Z [Term] id: GO:1903503 name: ATPase inhibitor complex namespace: cellular_component def: "A protein complex which is capable of ATPase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325] comment: An example of this is Mago in drome (P49028) in PMID:16170325 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-09-30T13:55:37Z [Term] id: GO:1903504 name: regulation of mitotic spindle checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent). subset: gocheck_do_not_manually_annotate synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090231 ! regulation of spindle checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071174 ! mitotic spindle checkpoint relationship: regulates GO:0071174 ! mitotic spindle checkpoint created_by: al creation_date: 2014-10-01T13:52:57Z [Term] id: GO:1903505 name: regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle." [GO_REF:0000058, GOC:TermGenie, PMID:24165938] is_a: GO:0071342 ! regulation of establishment of actomyosin contractile ring localization is_a: GO:1902471 ! regulation of mitotic actomyosin contractile ring localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903486 ! establishment of mitotic actomyosin contractile ring localization relationship: regulates GO:1903486 ! establishment of mitotic actomyosin contractile ring localization created_by: al creation_date: 2014-10-01T13:59:19Z [Term] id: GO:1903506 name: regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription relationship: regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:47Z [Term] id: GO:1903507 name: negative regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie] is_a: GO:1902679 ! negative regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:44:56Z [Term] id: GO:1903508 name: positive regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie] synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] is_a: GO:1902680 ! positive regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription created_by: pr creation_date: 2014-10-01T14:45:04Z [Term] id: GO:1903509 name: liposaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving liposaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964] synonym: "liposaccharide metabolism" EXACT [GOC:TermGenie] is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: dph creation_date: 2014-10-01T21:52:52Z [Term] id: GO:1903510 name: mucopolysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091] synonym: "mucopolysaccharide metabolism" EXACT [GOC:TermGenie] is_a: GO:0030203 ! glycosaminoglycan metabolic process created_by: dph creation_date: 2014-10-01T21:55:47Z [Term] id: GO:1903511 name: orotic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving orotic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:10727948] synonym: "orotic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process created_by: dph creation_date: 2014-10-01T21:58:06Z [Term] id: GO:1903512 name: phytanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytanic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:16799769] synonym: "phytanic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0097089 ! methyl-branched fatty acid metabolic process created_by: dph creation_date: 2014-10-01T22:00:29Z [Term] id: GO:1903513 name: endoplasmic reticulum to cytosol transport namespace: biological_process def: "The directed movement of substances from endoplasmic reticulum to cytosol." [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] synonym: "ER to cytosol transport" EXACT [GOC:TermGenie] is_a: GO:0046907 ! intracellular transport created_by: rl creation_date: 2014-10-02T11:24:34Z [Term] id: GO:1903514 name: release of sequestered calcium ion into cytosol by endoplasmic reticulum namespace: biological_process def: "The directed movement of calcium ion from endoplasmic reticulum to cytosol." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] synonym: "calcium ion transport from endoplasmic reticulum to cytosol" BROAD [] is_a: GO:0051209 ! release of sequestered calcium ion into cytosol created_by: rl creation_date: 2014-10-02T11:30:34Z [Term] id: GO:1903515 name: calcium ion transport from cytosol to endoplasmic reticulum namespace: biological_process def: "The directed movement of calcium ion from cytosol to endoplasmic reticulum." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport is_a: GO:0060401 ! cytosolic calcium ion transport is_a: GO:0070588 ! calcium ion transmembrane transport created_by: rl creation_date: 2014-10-02T14:51:20Z [Term] id: GO:1903516 name: regulation of single strand break repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] is_a: GO:0006282 ! regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000012 ! single strand break repair relationship: regulates GO:0000012 ! single strand break repair created_by: rl creation_date: 2014-10-06T10:58:52Z [Term] id: GO:1903517 name: negative regulation of single strand break repair namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] synonym: "down regulation of single strand break repair" EXACT [GOC:TermGenie] synonym: "down-regulation of single strand break repair" EXACT [GOC:TermGenie] synonym: "downregulation of single strand break repair" EXACT [GOC:TermGenie] synonym: "inhibition of single strand break repair" NARROW [GOC:TermGenie] is_a: GO:0045738 ! negative regulation of DNA repair is_a: GO:1903516 ! regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000012 ! single strand break repair relationship: negatively_regulates GO:0000012 ! single strand break repair created_by: rl creation_date: 2014-10-06T10:59:01Z [Term] id: GO:1903518 name: positive regulation of single strand break repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] synonym: "activation of single strand break repair" NARROW [GOC:TermGenie] synonym: "up regulation of single strand break repair" EXACT [GOC:TermGenie] synonym: "up-regulation of single strand break repair" EXACT [GOC:TermGenie] synonym: "upregulation of single strand break repair" EXACT [GOC:TermGenie] is_a: GO:0045739 ! positive regulation of DNA repair is_a: GO:1903516 ! regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000012 ! single strand break repair relationship: positively_regulates GO:0000012 ! single strand break repair created_by: rl creation_date: 2014-10-06T10:59:10Z [Term] id: GO:1903519 name: regulation of mammary gland involution namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060056 ! mammary gland involution relationship: regulates GO:0060056 ! mammary gland involution created_by: dph creation_date: 2014-10-06T12:01:22Z [Term] id: GO:1903520 name: negative regulation of mammary gland involution namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] synonym: "down regulation of mammary gland involution" EXACT [GOC:TermGenie] synonym: "down-regulation of mammary gland involution" EXACT [GOC:TermGenie] synonym: "downregulation of mammary gland involution" EXACT [GOC:TermGenie] synonym: "inhibition of mammary gland involution" NARROW [GOC:TermGenie] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1903519 ! regulation of mammary gland involution intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060056 ! mammary gland involution relationship: negatively_regulates GO:0060056 ! mammary gland involution created_by: dph creation_date: 2014-10-06T12:01:30Z [Term] id: GO:1903521 name: positive regulation of mammary gland involution namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] synonym: "activation of mammary gland involution" NARROW [GOC:TermGenie] synonym: "up regulation of mammary gland involution" EXACT [GOC:TermGenie] synonym: "up-regulation of mammary gland involution" EXACT [GOC:TermGenie] synonym: "upregulation of mammary gland involution" EXACT [GOC:TermGenie] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1903519 ! regulation of mammary gland involution intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060056 ! mammary gland involution relationship: positively_regulates GO:0060056 ! mammary gland involution created_by: dph creation_date: 2014-10-06T12:01:39Z [Term] id: GO:1903522 name: regulation of blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008015 ! blood circulation relationship: regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:38:56Z [Term] id: GO:1903523 name: negative regulation of blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008015 ! blood circulation relationship: negatively_regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:39:05Z [Term] id: GO:1903524 name: positive regulation of blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "activation of blood circulation" NARROW [GOC:TermGenie] synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008015 ! blood circulation relationship: positively_regulates GO:0008015 ! blood circulation created_by: mr creation_date: 2014-10-06T18:39:13Z [Term] id: GO:1903525 name: regulation of membrane tubulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] synonym: "regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "regulation of vesicle scission" RELATED [GOC:TermGenie] is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097320 ! plasma membrane tubulation relationship: regulates GO:0097320 ! plasma membrane tubulation created_by: pm creation_date: 2014-10-07T12:52:36Z [Term] id: GO:1903526 name: negative regulation of membrane tubulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] synonym: "down regulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "down regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "downregulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "downregulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "inhibition of membrane tubulation" NARROW [GOC:TermGenie] synonym: "inhibition of plasma membrane tubulation" NARROW [GOC:TermGenie] synonym: "negative regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903525 ! regulation of membrane tubulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097320 ! plasma membrane tubulation relationship: negatively_regulates GO:0097320 ! plasma membrane tubulation created_by: pm creation_date: 2014-10-07T12:52:45Z [Term] id: GO:1903527 name: positive regulation of membrane tubulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] synonym: "activation of membrane tubulation" NARROW [GOC:TermGenie] synonym: "activation of plasma membrane tubulation" NARROW [GOC:TermGenie] synonym: "positive regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "up regulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "up regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] synonym: "upregulation of membrane tubulation" EXACT [GOC:TermGenie] synonym: "upregulation of plasma membrane tubulation" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903525 ! regulation of membrane tubulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097320 ! plasma membrane tubulation relationship: positively_regulates GO:0097320 ! plasma membrane tubulation created_by: pm creation_date: 2014-10-07T12:52:53Z [Term] id: GO:1903528 name: regulation of dCDP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005] synonym: "regulation of dCDP anabolism" EXACT [GOC:TermGenie] synonym: "regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of dCDP formation" EXACT [GOC:TermGenie] synonym: "regulation of dCDP synthesis" EXACT [GOC:TermGenie] is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006240 ! dCDP biosynthetic process relationship: regulates GO:0006240 ! dCDP biosynthetic process created_by: al creation_date: 2014-10-07T15:01:18Z [Term] id: GO:1903529 name: negative regulation of dCDP biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005] synonym: "down regulation of dCDP anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of dCDP formation" EXACT [GOC:TermGenie] synonym: "down regulation of dCDP synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dCDP anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of dCDP formation" EXACT [GOC:TermGenie] synonym: "down-regulation of dCDP synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dCDP anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of dCDP biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of dCDP formation" EXACT [GOC:TermGenie] synonym: "downregulation of dCDP synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of dCDP anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of dCDP biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of dCDP biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of dCDP formation" NARROW [GOC:TermGenie] synonym: "inhibition of dCDP synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of dCDP anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of dCDP formation" EXACT [GOC:TermGenie] synonym: "negative regulation of dCDP synthesis" EXACT [GOC:TermGenie] is_a: GO:1900398 ! negative regulation of pyrimidine nucleotide biosynthetic process is_a: GO:1903528 ! regulation of dCDP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006240 ! dCDP biosynthetic process relationship: negatively_regulates GO:0006240 ! dCDP biosynthetic process created_by: al creation_date: 2014-10-07T15:01:27Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032940 ! secretion by cell relationship: regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032940 ! secretion by cell relationship: negatively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032940 ! secretion by cell relationship: positively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903533 name: regulation of protein targeting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein targeting." [GO_REF:0000058, GOC:TermGenie] synonym: "regulation of nascent polypeptide association" RELATED [GOC:TermGenie] synonym: "regulation of protein sorting along secretory pathway" NARROW [GOC:TermGenie] is_a: GO:0033157 ! regulation of intracellular protein transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006605 ! protein targeting relationship: regulates GO:0006605 ! protein targeting created_by: al creation_date: 2014-10-08T14:49:03Z [Term] id: GO:1903534 name: regulation of lactose biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] synonym: "regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "regulation of lactose synthesis" EXACT [GOC:TermGenie] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005989 ! lactose biosynthetic process relationship: regulates GO:0005989 ! lactose biosynthetic process created_by: mr creation_date: 2014-10-08T16:26:05Z [Term] id: GO:1903535 name: negative regulation of lactose biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] synonym: "down regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "down regulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "down-regulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of lactose formation" EXACT [GOC:TermGenie] synonym: "downregulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of lactose anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of lactose biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of lactose biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of lactose formation" NARROW [GOC:TermGenie] synonym: "inhibition of lactose synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "negative regulation of lactose synthesis" EXACT [GOC:TermGenie] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1903534 ! regulation of lactose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005989 ! lactose biosynthetic process relationship: negatively_regulates GO:0005989 ! lactose biosynthetic process created_by: mr creation_date: 2014-10-08T16:26:14Z [Term] id: GO:1903536 name: positive regulation of lactose biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] synonym: "activation of lactose anabolism" NARROW [GOC:TermGenie] synonym: "activation of lactose biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of lactose biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of lactose formation" NARROW [GOC:TermGenie] synonym: "activation of lactose synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "positive regulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "up regulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of lactose formation" EXACT [GOC:TermGenie] synonym: "up-regulation of lactose synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of lactose anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of lactose biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of lactose biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of lactose formation" EXACT [GOC:TermGenie] synonym: "upregulation of lactose synthesis" EXACT [GOC:TermGenie] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903534 ! regulation of lactose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005989 ! lactose biosynthetic process relationship: positively_regulates GO:0005989 ! lactose biosynthetic process created_by: mr creation_date: 2014-10-08T16:26:29Z [Term] id: GO:1903537 name: meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "meiosis involved in oocyte maturation" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1903046 ! meiotic cell cycle process intersection_of: part_of GO:0001556 ! oocyte maturation relationship: part_of GO:0001556 ! oocyte maturation created_by: pr creation_date: 2014-10-09T10:46:14Z [Term] id: GO:1903538 name: regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:1900193 ! regulation of oocyte maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation created_by: pr creation_date: 2014-10-09T10:52:38Z [Term] id: GO:1903539 name: protein localization to postsynaptic membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322] synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0035418 ! protein localization to synapse is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery created_by: kmv creation_date: 2014-10-10T11:23:53Z [Term] id: GO:1903540 name: establishment of protein localization to postsynaptic membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322] synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:1903539 ! protein localization to postsynaptic membrane created_by: kmv creation_date: 2014-10-10T11:24:03Z [Term] id: GO:1903541 name: regulation of exosomal secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990182 ! exosomal secretion relationship: regulates GO:1990182 ! exosomal secretion created_by: pga creation_date: 2014-10-14T11:38:52Z [Term] id: GO:1903542 name: negative regulation of exosomal secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990182 ! exosomal secretion relationship: negatively_regulates GO:1990182 ! exosomal secretion created_by: pga creation_date: 2014-10-14T11:39:02Z [Term] id: GO:1903543 name: positive regulation of exosomal secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990182 ! exosomal secretion relationship: positively_regulates GO:1990182 ! exosomal secretion created_by: pga creation_date: 2014-10-14T11:39:10Z [Term] id: GO:1903544 name: response to butyrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870] is_a: GO:0070542 ! response to fatty acid created_by: mr creation_date: 2014-10-17T13:57:25Z [Term] id: GO:1903545 name: cellular response to butyrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:1903544 ! response to butyrate created_by: mr creation_date: 2014-10-17T13:57:35Z [Term] id: GO:1903546 name: protein localization to photoreceptor outer segment namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment." [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699] synonym: "protein localisation in photoreceptor outer segment" EXACT [GOC:TermGenie] synonym: "protein localisation to photoreceptor outer segment" EXACT [GOC:TermGenie] synonym: "protein localization in photoreceptor outer segment" EXACT [GOC:TermGenie] is_a: GO:0097499 ! protein localization to non-motile cilium created_by: krc creation_date: 2014-10-17T21:14:11Z [Term] id: GO:1903547 name: regulation of growth hormone activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] synonym: "regulation of GH activity" EXACT [GOC:TermGenie] synonym: "regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "regulation of placental growth hormone activity" NARROW [GOC:TermGenie] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070186 ! growth hormone activity relationship: regulates GO:0070186 ! growth hormone activity created_by: mr creation_date: 2014-10-20T15:18:36Z [Term] id: GO:1903548 name: negative regulation of growth hormone activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] synonym: "down regulation of GH activity" EXACT [GOC:TermGenie] synonym: "down regulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "down regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "down regulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "down-regulation of GH activity" EXACT [GOC:TermGenie] synonym: "down-regulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "down-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "down-regulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "downregulation of GH activity" EXACT [GOC:TermGenie] synonym: "downregulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "downregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "downregulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "inhibition of GH activity" NARROW [GOC:TermGenie] synonym: "inhibition of growth hormone activity" NARROW [GOC:TermGenie] synonym: "inhibition of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "inhibition of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "negative regulation of GH activity" EXACT [GOC:TermGenie] synonym: "negative regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "negative regulation of placental growth hormone activity" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900121 ! negative regulation of receptor binding is_a: GO:1903547 ! regulation of growth hormone activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070186 ! growth hormone activity relationship: negatively_regulates GO:0070186 ! growth hormone activity created_by: mr creation_date: 2014-10-20T15:18:45Z [Term] id: GO:1903549 name: positive regulation of growth hormone activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] synonym: "activation of GH activity" NARROW [GOC:TermGenie] synonym: "activation of growth hormone activity" NARROW [GOC:TermGenie] synonym: "activation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "activation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "positive regulation of GH activity" EXACT [GOC:TermGenie] synonym: "positive regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "positive regulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "up regulation of GH activity" EXACT [GOC:TermGenie] synonym: "up regulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "up regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "up regulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "up-regulation of GH activity" EXACT [GOC:TermGenie] synonym: "up-regulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "up-regulation of placental growth hormone activity" NARROW [GOC:TermGenie] synonym: "upregulation of GH activity" EXACT [GOC:TermGenie] synonym: "upregulation of growth hormone activity" EXACT [GOC:TermGenie] synonym: "upregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] synonym: "upregulation of placental growth hormone activity" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:1903547 ! regulation of growth hormone activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070186 ! growth hormone activity relationship: positively_regulates GO:0070186 ! growth hormone activity created_by: mr creation_date: 2014-10-20T15:18:53Z [Term] id: GO:1903551 name: regulation of extracellular exosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071971 ! extracellular exosome assembly relationship: regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:25Z [Term] id: GO:1903552 name: negative regulation of extracellular exosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071971 ! extracellular exosome assembly relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:33Z [Term] id: GO:1903553 name: positive regulation of extracellular exosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071971 ! extracellular exosome assembly relationship: positively_regulates GO:0071971 ! extracellular exosome assembly created_by: pga creation_date: 2014-10-20T15:37:42Z [Term] id: GO:1903554 name: G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium namespace: biological_process def: "Any G protein-coupled receptor signaling pathway that is involved in defense response to Gram-negative bacterium." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:25303524] synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: part_of GO:0050829 ! defense response to Gram-negative bacterium relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium created_by: kmv creation_date: 2014-10-20T17:51:13Z [Term] id: GO:1903555 name: regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production relationship: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production created_by: pga creation_date: 2014-10-21T10:26:05Z [Term] id: GO:1903556 name: negative regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "down regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "down-regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "down-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "downregulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "downregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "inhibition of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "inhibition of TNFSF cytokine production" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] synonym: "negative regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "negative regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production relationship: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production created_by: pga creation_date: 2014-10-21T10:26:14Z [Term] id: GO:1903557 name: positive regulation of tumor necrosis factor superfamily cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "activation of TNFSF cytokine production" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] synonym: "positive regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "positive regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "up regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "up-regulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "up-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] synonym: "upregulation of TNF superfamily production" RELATED [GOC:TermGenie] synonym: "upregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production relationship: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production created_by: pga creation_date: 2014-10-21T10:26:23Z [Term] id: GO:1903558 name: 3-cyano-L-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] synonym: "3-cyano-L-alanine metabolism" EXACT [GOC:TermGenie] is_a: GO:0033052 ! cyanoamino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: kmv creation_date: 2014-10-21T17:13:00Z [Term] id: GO:1903559 name: 3-cyano-L-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] synonym: "3-cyano-L-alanine breakdown" EXACT [GOC:TermGenie] synonym: "3-cyano-L-alanine catabolism" EXACT [GOC:TermGenie] synonym: "3-cyano-L-alanine degradation" EXACT [GOC:TermGenie] is_a: GO:0050899 ! nitrile catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process created_by: kmv creation_date: 2014-10-21T17:13:10Z [Term] id: GO:1903560 name: 3-cyano-L-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] synonym: "3-cyano-L-alanine anabolism" EXACT [GOC:TermGenie] synonym: "3-cyano-L-alanine biosynthesis" EXACT [GOC:TermGenie] synonym: "3-cyano-L-alanine formation" EXACT [GOC:TermGenie] synonym: "3-cyano-L-alanine synthesis" EXACT [GOC:TermGenie] is_a: GO:0080028 ! nitrile biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process created_by: kmv creation_date: 2014-10-21T17:13:26Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005576 ! extracellular region created_by: jl creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903562 name: microtubule bundle formation involved in mitotic spindle midzone assembly namespace: biological_process def: "Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:15647375] synonym: "microtubule bundle formation involved in mitotic spindle midzone assembly" EXACT [GOC:TermGenie] synonym: "microtubule bundle formation involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie] synonym: "microtubule bundle formation involved in spindle midzone assembly involved in mitosis" EXACT [GOC:dos] synonym: "microtubule bundling involved in mitotic spindle midzone assembly" RELATED [GOC:TermGenie] synonym: "microtubule bundling involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in spindle midzone assembly involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in spindle midzone biogenesis involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in spindle midzone formation involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0001578 ! microtubule bundle formation intersection_of: part_of GO:0051256 ! mitotic spindle midzone assembly relationship: part_of GO:0051256 ! mitotic spindle midzone assembly created_by: vw creation_date: 2014-10-23T11:04:56Z [Term] id: GO:1903563 name: microtubule bundle formation involved in horsetail-astral microtubule organization namespace: biological_process def: "Any microtubule bundle formation that is involved in horsetail-astral microtubule organization." [GO_REF:0000060, GOC:TermGenie, PMID:15647375] synonym: "microtubule bundle formation involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie] synonym: "microtubule bundle formation involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie] synonym: "microtubule bundling involved in horsetail-astral microtubule organization" EXACT [GOC:TermGenie] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0001578 ! microtubule bundle formation intersection_of: part_of GO:0032118 ! horsetail-astral microtubule organization relationship: part_of GO:0032118 ! horsetail-astral microtubule organization created_by: vw creation_date: 2014-10-23T11:06:35Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061512 ! protein localization to cilium relationship: regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061512 ! protein localization to cilium relationship: negatively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061512 ! protein localization to cilium relationship: positively_regulates GO:0061512 ! protein localization to cilium created_by: krc creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903567 name: regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903441 ! protein localization to ciliary membrane relationship: regulates GO:1903441 ! protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:32:51Z [Term] id: GO:1903568 name: negative regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903565 ! negative regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903441 ! protein localization to ciliary membrane relationship: negatively_regulates GO:1903441 ! protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:32:59Z [Term] id: GO:1903569 name: positive regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903566 ! positive regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903441 ! protein localization to ciliary membrane relationship: positively_regulates GO:1903441 ! protein localization to ciliary membrane created_by: krc creation_date: 2014-10-24T21:33:08Z [Term] id: GO:1903570 name: regulation of protein kinase D signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] synonym: "regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0089700 ! protein kinase D signaling relationship: regulates GO:0089700 ! protein kinase D signaling created_by: rl creation_date: 2014-10-27T15:18:00Z [Term] id: GO:1903571 name: negative regulation of protein kinase D signaling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] synonym: "down regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "down regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "downregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of PKD signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of protein kinase D signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of protein kinase D signaling" NARROW [GOC:TermGenie] synonym: "inhibition of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] is_a: GO:1902532 ! negative regulation of intracellular signal transduction is_a: GO:1903570 ! regulation of protein kinase D signaling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0089700 ! protein kinase D signaling relationship: negatively_regulates GO:0089700 ! protein kinase D signaling created_by: rl creation_date: 2014-10-27T15:18:10Z [Term] id: GO:1903572 name: positive regulation of protein kinase D signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] synonym: "activation of PKD signal transduction" NARROW [GOC:TermGenie] synonym: "activation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of protein kinase D signal transduction" NARROW [GOC:TermGenie] synonym: "activation of protein kinase D signaling" NARROW [GOC:TermGenie] synonym: "activation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "positive regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "positive regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "up regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of PKD signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of PKD signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of protein kinase D signaling" EXACT [GOC:TermGenie] synonym: "upregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] is_a: GO:1902533 ! positive regulation of intracellular signal transduction is_a: GO:1903570 ! regulation of protein kinase D signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0089700 ! protein kinase D signaling relationship: positively_regulates GO:0089700 ! protein kinase D signaling created_by: rl creation_date: 2014-10-27T15:18:18Z [Term] id: GO:1903573 name: negative regulation of response to endoplasmic reticulum stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] synonym: "down regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "down regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down regulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "down-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of ER stress response" EXACT [GOC:TermGenie] synonym: "downregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "inhibition of ER stress response" NARROW [GOC:TermGenie] synonym: "inhibition of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "inhibition of response to ER stress" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "negative regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ER stress" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress relationship: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress created_by: bf creation_date: 2014-10-27T16:15:30Z [Term] id: GO:1903574 name: negative regulation of cellular response to amino acid starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] synonym: "down regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to amino acid starvation" NARROW [GOC:TermGenie] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:1903832 ! regulation of cellular response to amino acid starvation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034198 ! cellular response to amino acid starvation relationship: negatively_regulates GO:0034198 ! cellular response to amino acid starvation created_by: bf creation_date: 2014-10-27T16:21:02Z [Term] id: GO:1903575 name: cornified envelope assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope." [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495] comment: An example of this is syntaxin 4 in PMID:22226963. synonym: "cornified envelope formation" EXACT [GOC:TermGenie] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0071709 ! membrane assembly relationship: has_part GO:0003810 ! protein-glutamine gamma-glutamyltransferase activity created_by: pr creation_date: 2014-10-28T10:22:49Z [Term] id: GO:1903576 name: response to L-arginine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] is_a: GO:0007584 ! response to nutrient is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: mr creation_date: 2014-10-29T22:18:39Z [Term] id: GO:1903577 name: cellular response to L-arginine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1903576 ! response to L-arginine created_by: mr creation_date: 2014-10-29T22:18:54Z [Term] id: GO:1903578 name: regulation of ATP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046034 ! ATP metabolic process relationship: regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:24Z [Term] id: GO:1903579 name: negative regulation of ATP metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046034 ! ATP metabolic process relationship: negatively_regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:33Z [Term] id: GO:1903580 name: positive regulation of ATP metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046034 ! ATP metabolic process relationship: positively_regulates GO:0046034 ! ATP metabolic process created_by: sl creation_date: 2014-10-30T19:04:42Z [Term] id: GO:1903581 name: regulation of basophil degranulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0043300 ! regulation of leukocyte degranulation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002561 ! basophil degranulation relationship: regulates GO:0002561 ! basophil degranulation created_by: sl creation_date: 2014-10-31T17:37:24Z [Term] id: GO:1903582 name: negative regulation of basophil degranulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:1903581 ! regulation of basophil degranulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002561 ! basophil degranulation relationship: negatively_regulates GO:0002561 ! basophil degranulation created_by: sl creation_date: 2014-10-31T17:37:33Z [Term] id: GO:1903583 name: positive regulation of basophil degranulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie] synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie] synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:1903581 ! regulation of basophil degranulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002561 ! basophil degranulation relationship: positively_regulates GO:0002561 ! basophil degranulation created_by: sl creation_date: 2014-10-31T17:37:42Z [Term] id: GO:1903584 name: regulation of histone deubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689] synonym: "regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "regulation of histone deubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0090085 ! regulation of protein deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016578 ! histone deubiquitination relationship: regulates GO:0016578 ! histone deubiquitination created_by: lb creation_date: 2014-11-03T13:47:26Z [Term] id: GO:1903585 name: negative regulation of histone deubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689] synonym: "down regulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone deubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of histone deubiquitinylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone deubiquitylation" NARROW [GOC:TermGenie] synonym: "negative regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "negative regulation of histone deubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0090086 ! negative regulation of protein deubiquitination is_a: GO:1903584 ! regulation of histone deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016578 ! histone deubiquitination relationship: negatively_regulates GO:0016578 ! histone deubiquitination created_by: lb creation_date: 2014-11-03T13:47:35Z [Term] id: GO:1903586 name: positive regulation of histone deubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, Pubmed:24526689] synonym: "activation of histone deubiquitination" NARROW [GOC:TermGenie] synonym: "activation of histone deubiquitinylation" NARROW [GOC:TermGenie] synonym: "activation of histone deubiquitylation" NARROW [GOC:TermGenie] synonym: "positive regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "positive regulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "up regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "up-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone deubiquitylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone deubiquitination" EXACT [GOC:TermGenie] synonym: "upregulation of histone deubiquitinylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone deubiquitylation" EXACT [GOC:TermGenie] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:1903003 ! positive regulation of protein deubiquitination is_a: GO:1903584 ! regulation of histone deubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016578 ! histone deubiquitination relationship: positively_regulates GO:0016578 ! histone deubiquitination created_by: lb creation_date: 2014-11-03T13:47:44Z [Term] id: GO:1903587 name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] synonym: "regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:1903670 ! regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis relationship: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis created_by: pga creation_date: 2014-11-04T11:39:31Z [Term] id: GO:1903588 name: negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] synonym: "down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] is_a: GO:0001937 ! negative regulation of endothelial cell proliferation is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis is_a: GO:1903671 ! negative regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis relationship: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis created_by: pga creation_date: 2014-11-04T11:39:39Z [Term] id: GO:1903589 name: positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] synonym: "activation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] is_a: GO:0001938 ! positive regulation of endothelial cell proliferation is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis is_a: GO:1903672 ! positive regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis relationship: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis created_by: pga creation_date: 2014-11-04T11:39:47Z [Term] id: GO:1903590 name: regulation of lysozyme activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] synonym: "regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "regulation of globulin G" RELATED [GOC:TermGenie] synonym: "regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "regulation of L-7001" RELATED [GOC:TermGenie] synonym: "regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of PR1-lysozyme" RELATED [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003796 ! lysozyme activity relationship: regulates GO:0003796 ! lysozyme activity created_by: mr creation_date: 2014-11-05T21:41:22Z [Term] id: GO:1903591 name: negative regulation of lysozyme activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] synonym: "down regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of globulin G" RELATED [GOC:TermGenie] synonym: "down regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "down regulation of L-7001" RELATED [GOC:TermGenie] synonym: "down regulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "down regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "down regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "down-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of globulin G" RELATED [GOC:TermGenie] synonym: "down-regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "down-regulation of L-7001" RELATED [GOC:TermGenie] synonym: "down-regulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "down-regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "down-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "downregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of globulin G" RELATED [GOC:TermGenie] synonym: "downregulation of globulin G1" RELATED [GOC:TermGenie] synonym: "downregulation of L-7001" RELATED [GOC:TermGenie] synonym: "downregulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "downregulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "downregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "inhibition of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of globulin G" RELATED [GOC:TermGenie] synonym: "inhibition of globulin G1" RELATED [GOC:TermGenie] synonym: "inhibition of L-7001" RELATED [GOC:TermGenie] synonym: "inhibition of lysozyme activity" NARROW [GOC:TermGenie] synonym: "inhibition of lysozyme g" RELATED [GOC:TermGenie] synonym: "inhibition of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of muramidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "negative regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of globulin G" RELATED [GOC:TermGenie] synonym: "negative regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "negative regulation of L-7001" RELATED [GOC:TermGenie] synonym: "negative regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "negative regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of PR1-lysozyme" RELATED [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:1903590 ! regulation of lysozyme activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003796 ! lysozyme activity relationship: negatively_regulates GO:0003796 ! lysozyme activity created_by: mr creation_date: 2014-11-05T21:41:30Z [Term] id: GO:1903592 name: positive regulation of lysozyme activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] synonym: "activation of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie] synonym: "activation of globulin G" RELATED [GOC:TermGenie] synonym: "activation of globulin G1" RELATED [GOC:TermGenie] synonym: "activation of L-7001" RELATED [GOC:TermGenie] synonym: "activation of lysozyme activity" NARROW [GOC:TermGenie] synonym: "activation of lysozyme g" RELATED [GOC:TermGenie] synonym: "activation of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of muramidase activity" NARROW [GOC:TermGenie] synonym: "activation of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie] synonym: "activation of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "positive regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of globulin G" RELATED [GOC:TermGenie] synonym: "positive regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "positive regulation of L-7001" RELATED [GOC:TermGenie] synonym: "positive regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "positive regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "up regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of globulin G" RELATED [GOC:TermGenie] synonym: "up regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "up regulation of L-7001" RELATED [GOC:TermGenie] synonym: "up regulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "up regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "up regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "up-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of globulin G" RELATED [GOC:TermGenie] synonym: "up-regulation of globulin G1" RELATED [GOC:TermGenie] synonym: "up-regulation of L-7001" RELATED [GOC:TermGenie] synonym: "up-regulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "up-regulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "up-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PR1-lysozyme" RELATED [GOC:TermGenie] synonym: "upregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of globulin G" RELATED [GOC:TermGenie] synonym: "upregulation of globulin G1" RELATED [GOC:TermGenie] synonym: "upregulation of L-7001" RELATED [GOC:TermGenie] synonym: "upregulation of lysozyme activity" EXACT [GOC:TermGenie] synonym: "upregulation of lysozyme g" RELATED [GOC:TermGenie] synonym: "upregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of muramidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PR1-lysozyme" RELATED [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903590 ! regulation of lysozyme activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003796 ! lysozyme activity relationship: positively_regulates GO:0003796 ! lysozyme activity created_by: mr creation_date: 2014-11-05T21:41:39Z [Term] id: GO:1903593 name: regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0043304 ! regulation of mast cell degranulation is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002553 ! histamine secretion by mast cell relationship: regulates GO:0002553 ! histamine secretion by mast cell created_by: als creation_date: 2014-11-06T13:19:09Z [Term] id: GO:1903594 name: negative regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] synonym: "down regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "down-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "downregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "inhibition of histamine secretion by mast cell" NARROW [GOC:TermGenie] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0043305 ! negative regulation of mast cell degranulation is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002553 ! histamine secretion by mast cell relationship: negatively_regulates GO:0002553 ! histamine secretion by mast cell created_by: als creation_date: 2014-11-06T13:19:18Z [Term] id: GO:1903595 name: positive regulation of histamine secretion by mast cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] synonym: "activation of histamine secretion by mast cell" NARROW [GOC:TermGenie] synonym: "up regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "up-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0043306 ! positive regulation of mast cell degranulation is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002553 ! histamine secretion by mast cell relationship: positively_regulates GO:0002553 ! histamine secretion by mast cell created_by: als creation_date: 2014-11-06T13:19:26Z [Term] id: GO:1903596 name: regulation of gap junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016264 ! gap junction assembly relationship: regulates GO:0016264 ! gap junction assembly created_by: rl creation_date: 2014-11-07T18:51:36Z [Term] id: GO:1903597 name: negative regulation of gap junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] synonym: "down regulation of gap junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of gap junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of gap junction assembly" EXACT [GOC:TermGenie] synonym: "inhibition of gap junction assembly" NARROW [GOC:TermGenie] is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:1903596 ! regulation of gap junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016264 ! gap junction assembly relationship: negatively_regulates GO:0016264 ! gap junction assembly created_by: rl creation_date: 2014-11-07T18:51:45Z [Term] id: GO:1903598 name: positive regulation of gap junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] synonym: "activation of gap junction assembly" NARROW [GOC:TermGenie] synonym: "up regulation of gap junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of gap junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of gap junction assembly" EXACT [GOC:TermGenie] is_a: GO:1901890 ! positive regulation of cell junction assembly is_a: GO:1903596 ! regulation of gap junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016264 ! gap junction assembly relationship: positively_regulates GO:0016264 ! gap junction assembly created_by: rl creation_date: 2014-11-07T18:51:53Z [Term] id: GO:1903599 name: positive regulation of autophagy of mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002] comment: An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay synonym: "activation of mitochondrion degradation" RELATED [GOC:TermGenie] synonym: "activation of mitophagy" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial degradation" BROAD [GOC:TermGenie] synonym: "up regulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "up regulation of mitophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "up-regulation of mitophagy" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrion degradation" BROAD [GOC:TermGenie] synonym: "upregulation of mitophagy" EXACT [GOC:TermGenie] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:1903146 ! regulation of autophagy of mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000422 ! autophagy of mitochondrion relationship: positively_regulates GO:0000422 ! autophagy of mitochondrion created_by: pad creation_date: 2014-11-10T14:25:53Z [Term] id: GO:1903600 name: glutaminase complex namespace: cellular_component def: "A protein complex which is capable of glutaminase activity." [GO_REF:0000088, GOC:TermGenie, PMID:14764090] synonym: "Sno1p-Snz1p" EXACT [] is_a: GO:1902494 ! catalytic complex created_by: ew creation_date: 2014-11-11T18:41:42Z [Term] id: GO:1903601 name: thermospermine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] synonym: "thermospermine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process created_by: tb creation_date: 2014-11-12T18:47:55Z [Term] id: GO:1903602 name: thermospermine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] synonym: "thermospermine breakdown" EXACT [GOC:TermGenie] synonym: "thermospermine catabolism" EXACT [GOC:TermGenie] synonym: "thermospermine degradation" EXACT [GOC:TermGenie] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:1903601 ! thermospermine metabolic process created_by: tb creation_date: 2014-11-12T18:48:04Z [Term] id: GO:1903603 name: thermospermine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] synonym: "thermospermine anabolism" EXACT [GOC:TermGenie] synonym: "thermospermine biosynthesis" EXACT [GOC:TermGenie] synonym: "thermospermine formation" EXACT [GOC:TermGenie] synonym: "thermospermine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:1903601 ! thermospermine metabolic process created_by: tb creation_date: 2014-11-12T18:48:12Z [Term] id: GO:1903604 name: cytochrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] synonym: "cytochrome metabolism" EXACT [GOC:TermGenie] is_a: GO:0019538 ! protein metabolic process created_by: dph creation_date: 2014-11-13T20:01:09Z [Term] id: GO:1903605 name: cytochrome biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] synonym: "cytochrome anabolism" EXACT [GOC:TermGenie] synonym: "cytochrome biosynthesis" EXACT [GOC:TermGenie] synonym: "cytochrome formation" EXACT [GOC:TermGenie] synonym: "cytochrome synthesis" EXACT [GOC:TermGenie] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1903604 ! cytochrome metabolic process created_by: dph creation_date: 2014-11-13T20:01:18Z [Term] id: GO:1903606 name: cytochrome c metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] synonym: "cytochrome c metabolism" EXACT [GOC:TermGenie] is_a: GO:1903604 ! cytochrome metabolic process created_by: dph creation_date: 2014-11-13T20:01:27Z [Term] id: GO:1903607 name: cytochrome c biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] synonym: "cytochrome c anabolism" EXACT [GOC:TermGenie] synonym: "cytochrome c biosynthesis" EXACT [GOC:TermGenie] synonym: "cytochrome c formation" EXACT [GOC:TermGenie] synonym: "cytochrome c synthesis" EXACT [GOC:TermGenie] is_a: GO:1903605 ! cytochrome biosynthetic process is_a: GO:1903606 ! cytochrome c metabolic process created_by: dph creation_date: 2014-11-13T20:01:35Z [Term] id: GO:1903608 name: protein localization to cytoplasmic stress granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] synonym: "protein localisation in cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localisation to cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localization in cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localization to stress granule" BROAD [] is_a: GO:0033365 ! protein localization to organelle created_by: mah creation_date: 2014-11-14T16:20:32Z [Term] id: GO:1903609 name: negative regulation of inward rectifier potassium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18923542] synonym: "down regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of Kir channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of inward rectifier potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of Kir channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of Kir channel activity" EXACT [GOC:TermGenie] is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005242 ! inward rectifier potassium channel activity relationship: negatively_regulates GO:0005242 ! inward rectifier potassium channel activity created_by: rl creation_date: 2014-11-14T20:29:14Z [Term] id: GO:1903610 name: regulation of calcium-dependent ATPase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] is_a: GO:0043462 ! regulation of ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030899 ! calcium-dependent ATPase activity relationship: regulates GO:0030899 ! calcium-dependent ATPase activity created_by: sl creation_date: 2014-11-18T00:42:49Z [Term] id: GO:1903611 name: negative regulation of calcium-dependent ATPase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] synonym: "down regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of calcium-dependent ATPase activity" NARROW [GOC:TermGenie] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030899 ! calcium-dependent ATPase activity relationship: negatively_regulates GO:0030899 ! calcium-dependent ATPase activity created_by: sl creation_date: 2014-11-18T00:42:57Z [Term] id: GO:1903612 name: positive regulation of calcium-dependent ATPase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] synonym: "activation of calcium-dependent ATPase activity" NARROW [GOC:TermGenie] synonym: "up regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030899 ! calcium-dependent ATPase activity relationship: positively_regulates GO:0030899 ! calcium-dependent ATPase activity created_by: sl creation_date: 2014-11-18T00:43:06Z [Term] id: GO:1903613 name: regulation of protein tyrosine phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] synonym: "regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004725 ! protein tyrosine phosphatase activity relationship: regulates GO:0004725 ! protein tyrosine phosphatase activity created_by: sl creation_date: 2014-11-18T01:11:38Z [Term] id: GO:1903614 name: negative regulation of protein tyrosine phosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] synonym: "down regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "inhibition of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PPT-phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PTP-phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PTPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004725 ! protein tyrosine phosphatase activity relationship: negatively_regulates GO:0004725 ! protein tyrosine phosphatase activity created_by: sl creation_date: 2014-11-18T01:11:46Z [Term] id: GO:1903615 name: positive regulation of protein tyrosine phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] synonym: "activation of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie] synonym: "activation of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of PPT-phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of PTP-phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of PTPase activity" NARROW [GOC:TermGenie] synonym: "activation of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PTPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity relationship: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity created_by: sl creation_date: 2014-11-18T01:11:55Z [Term] id: GO:1903616 name: MAPK cascade involved in axon regeneration namespace: biological_process def: "Any MAPK cascade that is involved in axon regeneration." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19164707, PMID:19417215, PMID:19737525] synonym: "ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0000165 ! MAPK cascade intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0031103 ! axon regeneration relationship: part_of GO:0031103 ! axon regeneration created_by: kmv creation_date: 2014-11-18T19:11:59Z [Term] id: GO:1903617 name: positive regulation of mitotic cytokinesis, site selection namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, site selection." [GO_REF:0000058, GOC:TermGenie, PMID:21246752] is_a: GO:1902472 ! regulation of mitotic cytokinesis, site selection is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process is_a: GO:2000076 ! positive regulation cytokinesis, site selection intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902408 ! mitotic cytokinesis, site selection relationship: positively_regulates GO:1902408 ! mitotic cytokinesis, site selection created_by: vw creation_date: 2014-11-19T10:52:25Z [Term] id: GO:1903618 name: regulation of transdifferentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060290 ! transdifferentiation relationship: regulates GO:0060290 ! transdifferentiation created_by: jl creation_date: 2014-11-19T11:24:57Z [Term] id: GO:1903619 name: negative regulation of transdifferentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] synonym: "down regulation of transdifferentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of transdifferentiation" EXACT [GOC:TermGenie] synonym: "downregulation of transdifferentiation" EXACT [GOC:TermGenie] synonym: "inhibition of transdifferentiation" NARROW [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903618 ! regulation of transdifferentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060290 ! transdifferentiation relationship: negatively_regulates GO:0060290 ! transdifferentiation created_by: jl creation_date: 2014-11-19T11:25:05Z [Term] id: GO:1903620 name: positive regulation of transdifferentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] synonym: "activation of transdifferentiation" NARROW [GOC:TermGenie] synonym: "up regulation of transdifferentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of transdifferentiation" EXACT [GOC:TermGenie] synonym: "upregulation of transdifferentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903618 ! regulation of transdifferentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060290 ! transdifferentiation relationship: positively_regulates GO:0060290 ! transdifferentiation created_by: jl creation_date: 2014-11-19T11:25:14Z [Term] id: GO:1903621 name: protein localization to photoreceptor connecting cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium." [GO_REF:0000087, GOC:lb, GOC:TermGenie, PMID:25398945] synonym: "protein localisation in photoreceptor connecting cilium" EXACT [GOC:TermGenie] synonym: "protein localisation to photoreceptor connecting cilium" EXACT [GOC:TermGenie] synonym: "protein localization in photoreceptor connecting cilium" EXACT [GOC:TermGenie] is_a: GO:0097499 ! protein localization to non-motile cilium is_a: GO:1904491 ! protein localization to ciliary transition zone created_by: jl creation_date: 2014-11-19T17:17:17Z [Term] id: GO:1903622 name: regulation of RNA polymerase III activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932] synonym: "regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] is_a: GO:0006359 ! regulation of transcription by RNA polymerase III is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001056 ! RNA polymerase III activity relationship: regulates GO:0001056 ! RNA polymerase III activity created_by: al creation_date: 2014-11-19T18:24:29Z [Term] id: GO:1903623 name: negative regulation of RNA polymerase III activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932] synonym: "down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "down regulation of RNA polymerase III activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA polymerase III activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] synonym: "downregulation of RNA polymerase III activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie] synonym: "inhibition of RNA polymerase III activity" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] is_a: GO:0016480 ! negative regulation of transcription by RNA polymerase III is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1903622 ! regulation of RNA polymerase III activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001056 ! RNA polymerase III activity relationship: negatively_regulates GO:0001056 ! RNA polymerase III activity created_by: al creation_date: 2014-11-19T18:24:37Z [Term] id: GO:1903624 name: regulation of DNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006308 ! DNA catabolic process relationship: regulates GO:0006308 ! DNA catabolic process created_by: sl creation_date: 2014-11-19T22:36:35Z [Term] id: GO:1903625 name: negative regulation of DNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006308 ! DNA catabolic process relationship: negatively_regulates GO:0006308 ! DNA catabolic process created_by: sl creation_date: 2014-11-19T22:36:43Z [Term] id: GO:1903626 name: positive regulation of DNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie] synonym: "activation of DNA degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006308 ! DNA catabolic process relationship: positively_regulates GO:0006308 ! DNA catabolic process created_by: sl creation_date: 2014-11-19T22:36:51Z [Term] id: GO:1903627 name: regulation of dUTP diphosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] synonym: "regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of dUTPase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004170 ! dUTP diphosphatase activity relationship: regulates GO:0004170 ! dUTP diphosphatase activity created_by: sl creation_date: 2014-11-20T00:00:36Z [Term] id: GO:1903628 name: negative regulation of dUTP diphosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] synonym: "down regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of dUTP diphosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of dUTPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of dUTPase activity" EXACT [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:1903627 ! regulation of dUTP diphosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004170 ! dUTP diphosphatase activity relationship: negatively_regulates GO:0004170 ! dUTP diphosphatase activity created_by: sl creation_date: 2014-11-20T00:00:44Z [Term] id: GO:1903629 name: positive regulation of dUTP diphosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] synonym: "activation of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of dUTP diphosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of dUTPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of dUTPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of dUTPase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903627 ! regulation of dUTP diphosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004170 ! dUTP diphosphatase activity relationship: positively_regulates GO:0004170 ! dUTP diphosphatase activity created_by: sl creation_date: 2014-11-20T00:00:56Z [Term] id: GO:1903630 name: regulation of aminoacyl-tRNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004812 ! aminoacyl-tRNA ligase activity relationship: regulates GO:0004812 ! aminoacyl-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:22:04Z [Term] id: GO:1903631 name: negative regulation of aminoacyl-tRNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "down regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "down-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "downregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "inhibition of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "negative regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity relationship: negatively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:22:12Z [Term] id: GO:1903632 name: positive regulation of aminoacyl-tRNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "activation of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "positive regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "up regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "up-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] synonym: "upregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity relationship: positively_regulates GO:0004812 ! aminoacyl-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:22:20Z [Term] id: GO:1903633 name: regulation of leucine-tRNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004823 ! leucine-tRNA ligase activity relationship: regulates GO:0004823 ! leucine-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:24:48Z [Term] id: GO:1903634 name: negative regulation of leucine-tRNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "down regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "inhibition of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of leucine translase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004823 ! leucine-tRNA ligase activity relationship: negatively_regulates GO:0004823 ! leucine-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:24:56Z [Term] id: GO:1903635 name: positive regulation of leucine-tRNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] synonym: "activation of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "activation of leucine translase activity" NARROW [GOC:TermGenie] synonym: "activation of leucine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of leucine translase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004823 ! leucine-tRNA ligase activity relationship: positively_regulates GO:0004823 ! leucine-tRNA ligase activity created_by: sl creation_date: 2014-11-20T00:25:08Z [Term] id: GO:1903636 name: regulation of protein import into mitochondrial outer membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] synonym: "regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] is_a: GO:1903214 ! regulation of protein targeting to mitochondrion is_a: GO:1904589 ! regulation of protein import is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045040 ! protein insertion into mitochondrial outer membrane relationship: regulates GO:0045040 ! protein insertion into mitochondrial outer membrane created_by: pga creation_date: 2014-11-20T15:54:44Z [Term] id: GO:1903637 name: negative regulation of protein import into mitochondrial outer membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] synonym: "down regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "down regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "down-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "downregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie] synonym: "inhibition of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "negative regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion is_a: GO:1903636 ! regulation of protein import into mitochondrial outer membrane is_a: GO:1904590 ! negative regulation of protein import is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane relationship: negatively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane created_by: pga creation_date: 2014-11-20T15:54:53Z [Term] id: GO:1903638 name: positive regulation of protein import into mitochondrial outer membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein import into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] synonym: "activation of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie] synonym: "activation of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "activation of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "activation of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "positive regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "up regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "up-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] synonym: "upregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] is_a: GO:1903636 ! regulation of protein import into mitochondrial outer membrane is_a: GO:1903955 ! positive regulation of protein targeting to mitochondrion is_a: GO:1904591 ! positive regulation of protein import is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane relationship: positively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane created_by: pga creation_date: 2014-11-20T15:55:01Z [Term] id: GO:1903639 name: regulation of gastrin-induced gastric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] is_a: GO:0060453 ! regulation of gastric acid secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001698 ! gastrin-induced gastric acid secretion relationship: regulates GO:0001698 ! gastrin-induced gastric acid secretion created_by: sl creation_date: 2014-11-20T20:54:20Z [Term] id: GO:1903640 name: negative regulation of gastrin-induced gastric acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] synonym: "down regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] synonym: "downregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] synonym: "inhibition of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie] is_a: GO:0060455 ! negative regulation of gastric acid secretion is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion relationship: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion created_by: sl creation_date: 2014-11-20T20:54:28Z [Term] id: GO:1903641 name: positive regulation of gastrin-induced gastric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] synonym: "activation of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie] synonym: "up regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] synonym: "upregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] is_a: GO:0060454 ! positive regulation of gastric acid secretion is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion relationship: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion created_by: sl creation_date: 2014-11-20T20:54:37Z [Term] id: GO:1903642 name: regulation of recombination hotspot binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749] synonym: "regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010844 ! recombination hotspot binding relationship: regulates GO:0010844 ! recombination hotspot binding created_by: al creation_date: 2014-11-21T12:02:22Z [Term] id: GO:1903643 name: positive regulation of recombination hotspot binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749] synonym: "activation of DNA binding, recombination hotspot" NARROW [GOC:TermGenie] synonym: "activation of recombination hotspot binding" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] synonym: "up regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] synonym: "up regulation of recombination hotspot binding" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] synonym: "up-regulation of recombination hotspot binding" EXACT [GOC:TermGenie] synonym: "upregulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] synonym: "upregulation of recombination hotspot binding" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:1903642 ! regulation of recombination hotspot binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010844 ! recombination hotspot binding relationship: positively_regulates GO:0010844 ! recombination hotspot binding created_by: al creation_date: 2014-11-21T12:02:31Z [Term] id: GO:1903644 name: regulation of chaperone-mediated protein folding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] is_a: GO:1903332 ! regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061077 ! chaperone-mediated protein folding relationship: regulates GO:0061077 ! chaperone-mediated protein folding created_by: pga creation_date: 2014-11-21T15:25:27Z [Term] id: GO:1903645 name: negative regulation of chaperone-mediated protein folding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] synonym: "down regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] synonym: "down-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] synonym: "downregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] synonym: "inhibition of chaperone-mediated protein folding" NARROW [GOC:TermGenie] is_a: GO:1903333 ! negative regulation of protein folding is_a: GO:1903644 ! regulation of chaperone-mediated protein folding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061077 ! chaperone-mediated protein folding relationship: negatively_regulates GO:0061077 ! chaperone-mediated protein folding created_by: pga creation_date: 2014-11-21T15:25:35Z [Term] id: GO:1903646 name: positive regulation of chaperone-mediated protein folding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] synonym: "activation of chaperone-mediated protein folding" NARROW [GOC:TermGenie] synonym: "up regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] synonym: "up-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] synonym: "upregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] is_a: GO:1903334 ! positive regulation of protein folding is_a: GO:1903644 ! regulation of chaperone-mediated protein folding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061077 ! chaperone-mediated protein folding relationship: positively_regulates GO:0061077 ! chaperone-mediated protein folding created_by: pga creation_date: 2014-11-21T15:25:44Z [Term] id: GO:1903647 name: negative regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469] synonym: "down regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "inhibition of chlorophyll breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of chlorophyll degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie] is_a: GO:0010271 ! regulation of chlorophyll catabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015996 ! chlorophyll catabolic process relationship: negatively_regulates GO:0015996 ! chlorophyll catabolic process created_by: tb creation_date: 2014-11-22T00:18:25Z [Term] id: GO:1903648 name: positive regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469] synonym: "activation of chlorophyll breakdown" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll catabolic process" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll catabolism" NARROW [GOC:TermGenie] synonym: "activation of chlorophyll degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of chlorophyll degradation" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie] is_a: GO:0010271 ! regulation of chlorophyll catabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015996 ! chlorophyll catabolic process relationship: positively_regulates GO:0015996 ! chlorophyll catabolic process created_by: tb creation_date: 2014-11-22T00:18:34Z [Term] id: GO:1903649 name: regulation of cytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016482 ! cytosolic transport relationship: regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:17Z [Term] id: GO:1903650 name: negative regulation of cytoplasmic transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie] synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016482 ! cytosolic transport relationship: negatively_regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:26Z [Term] id: GO:1903651 name: positive regulation of cytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie] synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016482 ! cytosolic transport relationship: positively_regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:34Z [Term] id: GO:1903652 name: modulation by virus of host cytoplasmic transport namespace: biological_process def: "Modulation by an infecting virus of host cytoplasmic transport." [GO_REF:0000063, GOC:TermGenie, PMID:25049409] synonym: "regulation by virus of host cytoplasmic streaming" EXACT [] synonym: "regulation by virus of host cytoplasmic transport" EXACT [] synonym: "viral modulation of host cytoplasmic trafficking" EXACT [] is_a: GO:0019054 ! modulation by virus of host cellular process is_a: GO:0052038 ! modulation by symbiont of host intracellular transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0019054 ! modulation by virus of host cellular process intersection_of: regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T17:22:04Z [Term] id: GO:1903653 name: modulation by symbiont of host cell motility namespace: biological_process def: "Modulation of host cell motility by a symbiont of that host." [GO_REF:0000063, GOC:TermGenie, PMID:25049409] synonym: "modulation by symbiont of host cell locomotion" EXACT [] synonym: "modulation by symbiont of host cell movement" RELATED [] synonym: "regulation by symbiont of host cell motility" EXACT [] is_a: GO:0044068 ! modulation by symbiont of host cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: regulates GO:0048870 ! cell motility created_by: jl creation_date: 2014-11-24T17:37:56Z [Term] id: GO:1903654 name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067] is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues intersection_of: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues intersection_of: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter created_by: vw creation_date: 2014-11-25T11:00:43Z [Term] id: GO:1903655 name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067] is_a: GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues intersection_of: GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues intersection_of: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter created_by: vw creation_date: 2014-11-25T11:04:16Z [Term] id: GO:1903656 name: regulation of type IV pilus biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0060491 ! regulation of cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043683 ! type IV pilus biogenesis relationship: regulates GO:0043683 ! type IV pilus biogenesis created_by: jl creation_date: 2014-11-25T12:03:09Z [Term] id: GO:1903657 name: negative regulation of type IV pilus biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "down regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of TFP biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type 4 pilus biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbria assembly" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbria biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbriae assembly" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbriae biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbrial assembly" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbrial biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbrium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of type IV fimbrium biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV pilus biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of type IV pilus biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:1903656 ! regulation of type IV pilus biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043683 ! type IV pilus biogenesis relationship: negatively_regulates GO:0043683 ! type IV pilus biogenesis created_by: jl creation_date: 2014-11-25T12:03:24Z [Term] id: GO:1903658 name: positive regulation of type IV pilus biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] synonym: "activation of TFP biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type 4 pilus biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbria assembly" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbria biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbriae assembly" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbriae biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbrial assembly" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbrial biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbrium assembly" NARROW [GOC:TermGenie] synonym: "activation of type IV fimbrium biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV pilus biogenesis" NARROW [GOC:TermGenie] synonym: "activation of type IV pilus biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "up regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of TFP biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbria assembly" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] synonym: "upregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1903656 ! regulation of type IV pilus biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043683 ! type IV pilus biogenesis relationship: positively_regulates GO:0043683 ! type IV pilus biogenesis created_by: jl creation_date: 2014-11-25T12:03:34Z [Term] id: GO:1903659 name: regulation of complement-dependent cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] is_a: GO:0031341 ! regulation of cell killing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097278 ! complement-dependent cytotoxicity relationship: regulates GO:0097278 ! complement-dependent cytotoxicity created_by: jl creation_date: 2014-11-25T15:03:54Z [Term] id: GO:1903660 name: negative regulation of complement-dependent cytotoxicity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] synonym: "down regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] synonym: "down-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] synonym: "downregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] synonym: "inhibition of complement-dependent cytotoxicity" NARROW [GOC:TermGenie] is_a: GO:0031342 ! negative regulation of cell killing is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity relationship: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity created_by: jl creation_date: 2014-11-25T15:04:02Z [Term] id: GO:1903661 name: positive regulation of complement-dependent cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] synonym: "activation of complement-dependent cytotoxicity" NARROW [GOC:TermGenie] synonym: "up regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] synonym: "up-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] synonym: "upregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] is_a: GO:0031343 ! positive regulation of cell killing is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097278 ! complement-dependent cytotoxicity relationship: positively_regulates GO:0097278 ! complement-dependent cytotoxicity created_by: jl creation_date: 2014-11-25T15:04:11Z [Term] id: GO:1903662 name: L-altrarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980] synonym: "L-altrarate(1-) metabolism" EXACT [GOC:TermGenie] is_a: GO:0019577 ! aldaric acid metabolic process created_by: jl creation_date: 2014-11-26T14:34:20Z [Term] id: GO:1903663 name: L-altrarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980] synonym: "L-altrarate(1-) breakdown" EXACT [GOC:TermGenie] synonym: "L-altrarate(1-) catabolism" EXACT [GOC:TermGenie] synonym: "L-altrarate(1-) degradation" EXACT [GOC:TermGenie] is_a: GO:0019579 ! aldaric acid catabolic process is_a: GO:1903662 ! L-altrarate metabolic process created_by: jl creation_date: 2014-11-26T14:34:28Z [Term] id: GO:1903664 name: regulation of asexual reproduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019954 ! asexual reproduction relationship: regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:24Z [Term] id: GO:1903665 name: negative regulation of asexual reproduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] synonym: "down regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "down-regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "downregulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "inhibition of asexual reproduction" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019954 ! asexual reproduction relationship: negatively_regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:32Z [Term] id: GO:1903666 name: positive regulation of asexual reproduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] synonym: "activation of asexual reproduction" NARROW [GOC:TermGenie] synonym: "up regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "up-regulation of asexual reproduction" EXACT [GOC:TermGenie] synonym: "upregulation of asexual reproduction" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019954 ! asexual reproduction relationship: positively_regulates GO:0019954 ! asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:40Z [Term] id: GO:1903667 name: regulation of chemorepellent activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] synonym: "regulation of chemorepellant activity" EXACT [GOC:TermGenie] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0050923 ! regulation of negative chemotaxis is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045499 ! chemorepellent activity relationship: regulates GO:0045499 ! chemorepellent activity created_by: pf creation_date: 2014-11-26T23:58:33Z [Term] id: GO:1903668 name: negative regulation of chemorepellent activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] synonym: "down regulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "down regulation of chemorepellent activity" EXACT [GOC:TermGenie] synonym: "down-regulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "down-regulation of chemorepellent activity" EXACT [GOC:TermGenie] synonym: "downregulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "downregulation of chemorepellent activity" EXACT [GOC:TermGenie] synonym: "inhibition of chemorepellant activity" NARROW [GOC:TermGenie] synonym: "inhibition of chemorepellent activity" NARROW [GOC:TermGenie] synonym: "negative regulation of chemorepellant activity" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0050925 ! negative regulation of negative chemotaxis is_a: GO:1900121 ! negative regulation of receptor binding is_a: GO:1903667 ! regulation of chemorepellent activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045499 ! chemorepellent activity relationship: negatively_regulates GO:0045499 ! chemorepellent activity created_by: pf creation_date: 2014-11-26T23:58:42Z [Term] id: GO:1903669 name: positive regulation of chemorepellent activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] synonym: "activation of chemorepellant activity" NARROW [GOC:TermGenie] synonym: "activation of chemorepellent activity" NARROW [GOC:TermGenie] synonym: "positive regulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "up regulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "up regulation of chemorepellent activity" EXACT [GOC:TermGenie] synonym: "up-regulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "up-regulation of chemorepellent activity" EXACT [GOC:TermGenie] synonym: "upregulation of chemorepellant activity" EXACT [GOC:TermGenie] synonym: "upregulation of chemorepellent activity" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0050924 ! positive regulation of negative chemotaxis is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:1903667 ! regulation of chemorepellent activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045499 ! chemorepellent activity relationship: positively_regulates GO:0045499 ! chemorepellent activity created_by: pf creation_date: 2014-11-26T23:58:50Z [Term] id: GO:1903670 name: regulation of sprouting angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] is_a: GO:0045765 ! regulation of angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002040 ! sprouting angiogenesis relationship: regulates GO:0002040 ! sprouting angiogenesis created_by: pga creation_date: 2014-11-27T10:10:51Z [Term] id: GO:1903671 name: negative regulation of sprouting angiogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] synonym: "down regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of sprouting angiogenesis" NARROW [GOC:TermGenie] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:1903670 ! regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002040 ! sprouting angiogenesis relationship: negatively_regulates GO:0002040 ! sprouting angiogenesis created_by: pga creation_date: 2014-11-27T10:10:59Z [Term] id: GO:1903672 name: positive regulation of sprouting angiogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] synonym: "activation of sprouting angiogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of sprouting angiogenesis" EXACT [GOC:TermGenie] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:1903670 ! regulation of sprouting angiogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002040 ! sprouting angiogenesis relationship: positively_regulates GO:0002040 ! sprouting angiogenesis created_by: pga creation_date: 2014-11-27T10:11:08Z [Term] id: GO:1903673 name: mitotic cleavage furrow formation namespace: biological_process def: "Any cleavage furrow formation that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "cleavage furrow positioning involved in mitotic cell cycle" NARROW [GOC:TermGenie] is_a: GO:0036089 ! cleavage furrow formation is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0036089 ! cleavage furrow formation intersection_of: part_of GO:0000278 ! mitotic cell cycle created_by: jl creation_date: 2014-11-27T15:32:18Z [Term] id: GO:1903674 name: regulation of cap-dependent translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002191 ! cap-dependent translational initiation relationship: regulates GO:0002191 ! cap-dependent translational initiation created_by: bf creation_date: 2014-11-27T19:50:23Z [Term] id: GO:1903675 name: negative regulation of cap-dependent translational initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] synonym: "downregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] synonym: "inhibition of cap-dependent translational initiation" NARROW [GOC:TermGenie] is_a: GO:1903674 ! regulation of cap-dependent translational initiation is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002191 ! cap-dependent translational initiation relationship: negatively_regulates GO:0002191 ! cap-dependent translational initiation created_by: bf creation_date: 2014-11-27T19:50:31Z [Term] id: GO:1903676 name: positive regulation of cap-dependent translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995] synonym: "activation of cap-dependent translational initiation" NARROW [GOC:TermGenie] synonym: "up regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] synonym: "upregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] is_a: GO:1903674 ! regulation of cap-dependent translational initiation is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002191 ! cap-dependent translational initiation relationship: positively_regulates GO:0002191 ! cap-dependent translational initiation created_by: bf creation_date: 2014-11-27T19:50:39Z [Term] id: GO:1903677 name: regulation of cap-independent translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002190 ! cap-independent translational initiation relationship: regulates GO:0002190 ! cap-independent translational initiation created_by: bf creation_date: 2014-11-27T19:52:20Z [Term] id: GO:1903678 name: negative regulation of cap-independent translational initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] synonym: "downregulation of cap-independent translational initiation" EXACT [GOC:TermGenie] synonym: "inhibition of cap-independent translational initiation" NARROW [GOC:TermGenie] is_a: GO:1903677 ! regulation of cap-independent translational initiation is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002190 ! cap-independent translational initiation relationship: negatively_regulates GO:0002190 ! cap-independent translational initiation created_by: bf creation_date: 2014-11-27T19:52:28Z [Term] id: GO:1903679 name: positive regulation of cap-independent translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995] synonym: "activation of cap-independent translational initiation" NARROW [GOC:TermGenie] synonym: "up regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] synonym: "upregulation of cap-independent translational initiation" EXACT [GOC:TermGenie] is_a: GO:1903677 ! regulation of cap-independent translational initiation is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002190 ! cap-independent translational initiation relationship: positively_regulates GO:0002190 ! cap-independent translational initiation created_by: bf creation_date: 2014-11-27T19:52:36Z [Term] id: GO:1903680 name: acinar cell of sebaceous gland differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland." [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183] synonym: "sebocyte differentiation" EXACT [CL:0002140] is_a: GO:0001949 ! sebaceous gland cell differentiation is_a: GO:0090425 ! acinar cell differentiation created_by: cynthia.smith creation_date: 2014-11-30T11:51:57Z [Term] id: GO:1903681 name: regulation of epithelial cell-cell adhesion involved in epithelium migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration relationship: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration created_by: als creation_date: 2014-12-01T13:25:05Z [Term] id: GO:1903682 name: negative regulation of epithelial cell-cell adhesion involved in epithelium migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "down regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration relationship: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration created_by: als creation_date: 2014-12-01T13:25:14Z [Term] id: GO:1903683 name: positive regulation of epithelial cell-cell adhesion involved in epithelium migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "activation of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration relationship: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration created_by: als creation_date: 2014-12-01T13:25:22Z [Term] id: GO:1903684 name: regulation of border follicle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "regulation of border cell migration" BROAD [GOC:TermGenie] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007298 ! border follicle cell migration relationship: regulates GO:0007298 ! border follicle cell migration created_by: als creation_date: 2014-12-01T13:35:39Z [Term] id: GO:1903687 name: negative regulation of border follicle cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "inhibition of border follicle cell migration" NARROW [GOC:TermGenie] is_a: GO:0010633 ! negative regulation of epithelial cell migration is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:1903684 ! regulation of border follicle cell migration is_a: GO:1905880 ! negative regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007298 ! border follicle cell migration relationship: negatively_regulates GO:0007298 ! border follicle cell migration created_by: als creation_date: 2014-12-01T13:41:05Z [Term] id: GO:1903688 name: positive regulation of border follicle cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "activation of border follicle cell migration" NARROW [GOC:TermGenie] is_a: GO:0010634 ! positive regulation of epithelial cell migration is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:1903684 ! regulation of border follicle cell migration is_a: GO:1905881 ! positive regulation of oogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007298 ! border follicle cell migration relationship: positively_regulates GO:0007298 ! border follicle cell migration created_by: als creation_date: 2014-12-01T13:41:19Z [Term] id: GO:1903689 name: regulation of wound healing, spreading of epidermal cells namespace: biological_process def: "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0061041 ! regulation of wound healing is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035313 ! wound healing, spreading of epidermal cells relationship: regulates GO:0035313 ! wound healing, spreading of epidermal cells created_by: als creation_date: 2014-12-01T15:54:18Z [Term] id: GO:1903690 name: negative regulation of wound healing, spreading of epidermal cells namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "down regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] synonym: "down-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] synonym: "downregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] synonym: "inhibition of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells relationship: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells created_by: als creation_date: 2014-12-01T15:54:27Z [Term] id: GO:1903691 name: positive regulation of wound healing, spreading of epidermal cells namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] synonym: "activation of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie] synonym: "up regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] synonym: "up-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] synonym: "upregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells relationship: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells created_by: als creation_date: 2014-12-01T15:54:35Z [Term] id: GO:1903692 name: methionine import across plasma membrane namespace: biological_process alt_id: GO:0044690 def: "The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] synonym: "methionine import" BROAD [] synonym: "methionine import into cell" EXACT [] is_a: GO:0015821 ! methionine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport created_by: janelomax creation_date: 2012-08-15T14:54:38Z [Term] id: GO:1903693 name: regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656] synonym: "regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0071156 ! regulation of cell cycle arrest is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation relationship: regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation created_by: al creation_date: 2014-12-02T18:16:03Z [Term] id: GO:1903694 name: positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656] synonym: "activation of G1 mitotic cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie] synonym: "activation of mitotic G1 cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie] synonym: "positive regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "up regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "up-regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "upregulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] is_a: GO:0071158 ! positive regulation of cell cycle arrest is_a: GO:1903693 ! regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation relationship: positively_regulates GO:0071851 ! mitotic G1 cell cycle arrest in response to nitrogen starvation created_by: al creation_date: 2014-12-02T18:16:16Z [Term] id: GO:1903695 name: MAPK cascade involved in ascospore formation namespace: biological_process def: "Any MAPK cascade that is involved in ascospore formation." [GO_REF:0000060, GOC:TermGenie, PMID:8443406] synonym: "ERK/MAPK cascade involved in ascospore biosynthesis" NARROW [GOC:TermGenie] synonym: "ERK/MAPK cascade involved in ascospore formation" NARROW [GOC:TermGenie] synonym: "MAP kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "MAP kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "MAP kinase kinase kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "MAP kinase kinase kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "MAPK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "MAPK signal transduction involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "MAPK signal transduction involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "MAPK signaling involved in ascospore biosynthesis" RELATED [GOC:TermGenie] synonym: "MAPK signaling involved in ascospore formation" RELATED [GOC:TermGenie] synonym: "MAPK signalling involved in ascospore biosynthesis" RELATED [GOC:TermGenie] synonym: "MAPK signalling involved in ascospore formation" RELATED [GOC:TermGenie] synonym: "MAPKKK cascade during sporulation involved in ascospore biosynthesis" NARROW [GOC:TermGenie] synonym: "MAPKKK cascade during sporulation involved in ascospore formation" NARROW [GOC:TermGenie] synonym: "MAPKKK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "MAPKKK cascade involved in ascospore formation" EXACT [GOC:TermGenie] synonym: "mitogen-activated protein kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] synonym: "mitogen-activated protein kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] is_a: GO:0000165 ! MAPK cascade is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0030437 ! ascospore formation relationship: part_of GO:0030437 ! ascospore formation created_by: al creation_date: 2014-12-02T22:09:18Z [Term] id: GO:1903696 name: protein localization to horsetail-astral microtubule array namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array." [GO_REF:0000087, GOC:TermGenie, PMID:11907273] synonym: "protein localisation in horsetail-astral microtubule array" EXACT [GOC:TermGenie] synonym: "protein localisation to horsetail-astral microtubule array" EXACT [GOC:TermGenie] synonym: "protein localization in horsetail-astral microtubule array" EXACT [GOC:TermGenie] is_a: GO:0072699 ! protein localization to cortical microtubule cytoskeleton created_by: mah creation_date: 2014-12-03T10:58:18Z [Term] id: GO:1903697 name: negative regulation of microvillus assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030033 ! microvillus assembly relationship: negatively_regulates GO:0030033 ! microvillus assembly created_by: als creation_date: 2014-12-03T11:45:08Z [Term] id: GO:1903698 name: positive regulation of microvillus assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030033 ! microvillus assembly relationship: positively_regulates GO:0030033 ! microvillus assembly created_by: als creation_date: 2014-12-03T11:45:17Z [Term] id: GO:1903699 name: tarsal gland development namespace: biological_process def: "The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:20664693] synonym: "gland of Meibom development" EXACT [GOC:TermGenie] synonym: "glandula tarsales development" EXACT [GOC:TermGenie] synonym: "Meibomian gland development" EXACT [GOC:TermGenie] synonym: "tarsoconjunctival gland development" RELATED [GOC:TermGenie] is_a: GO:0048733 ! sebaceous gland development created_by: cynthia.smith creation_date: 2014-12-03T11:47:07Z [Term] id: GO:1903700 name: caecum development namespace: biological_process def: "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "blind intestine development" RELATED [GOC:TermGenie] synonym: "blindgut development" RELATED [GOC:TermGenie] synonym: "caeca development" NARROW [GOC:TermGenie] synonym: "ceca development" NARROW [GOC:TermGenie] synonym: "cecum development" EXACT [GOC:TermGenie] synonym: "intestinum caecum development" RELATED [GOC:TermGenie] synonym: "intestinum crassum caecum development" EXACT [GOC:TermGenie] synonym: "intestinum crassum cecum development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: cynthia.smith creation_date: 2014-12-03T12:05:00Z [Term] id: GO:1903701 name: substantia propria of cornea development namespace: biological_process def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382] synonym: "corneal stroma development" EXACT [GOC:TermGenie] synonym: "stroma of cornea development" EXACT [GOC:TermGenie] synonym: "substantia propria development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: cynthia.smith creation_date: 2014-12-03T13:12:09Z [Term] id: GO:1903702 name: esophagus development namespace: biological_process def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "esophageal development" EXACT [MGI:csmith] synonym: "gullet development" EXACT [GOC:TermGenie] synonym: "oesophagus development" EXACT [GOC:TermGenie] is_a: GO:0048513 ! animal organ development created_by: cynthia.smith creation_date: 2014-12-03T14:41:30Z [Term] id: GO:1903703 name: enterocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte." [GO_REF:0000086, GOC:TermGenie, http://en.wikipedia.org/wiki/List_of_intestinal_epithelial_differentiation_genes, PMID:16782882] is_a: GO:0060575 ! intestinal epithelial cell differentiation created_by: cynthia.smith creation_date: 2014-12-03T15:08:51Z [Term] id: GO:1903704 name: negative regulation of production of siRNA involved in RNA interference namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182] synonym: "down regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "down regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "down regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "down regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "down-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "downregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "downregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "downregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "downregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "inhibition of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie] synonym: "inhibition of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie] synonym: "inhibition of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie] synonym: "inhibition of RNA interference, production of siRNA" NARROW [GOC:TermGenie] synonym: "negative regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference is_a: GO:1900369 ! negative regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030422 ! production of siRNA involved in RNA interference relationship: negatively_regulates GO:0030422 ! production of siRNA involved in RNA interference created_by: nc creation_date: 2014-12-03T15:13:22Z [Term] id: GO:1903705 name: positive regulation of production of siRNA involved in RNA interference namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182] synonym: "activation of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie] synonym: "activation of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie] synonym: "activation of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie] synonym: "activation of RNA interference, production of siRNA" NARROW [GOC:TermGenie] synonym: "positive regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "up regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "up regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "up regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "up regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "up-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] synonym: "upregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] synonym: "upregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] synonym: "upregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] synonym: "upregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference is_a: GO:1900370 ! positive regulation of RNA interference intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030422 ! production of siRNA involved in RNA interference relationship: positively_regulates GO:0030422 ! production of siRNA involved in RNA interference created_by: nc creation_date: 2014-12-03T15:13:30Z [Term] id: GO:1903706 name: regulation of hemopoiesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030097 ! hemopoiesis relationship: regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:13Z [Term] id: GO:1903707 name: negative regulation of hemopoiesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030097 ! hemopoiesis relationship: negatively_regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:21Z [Term] id: GO:1903708 name: positive regulation of hemopoiesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030097 ! hemopoiesis relationship: positively_regulates GO:0030097 ! hemopoiesis created_by: pad creation_date: 2014-12-04T15:34:30Z [Term] id: GO:1903709 name: uterine gland development namespace: biological_process def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340] synonym: "endometrial gland development" EXACT [GOC:TermGenie] synonym: "endometrium gland development" EXACT [GOC:TermGenie] synonym: "glandulae uterinae development" RELATED [GOC:TermGenie] synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie] synonym: "set of uterine glands development" RELATED [GOC:TermGenie] synonym: "uterine glands development" EXACT [GOC:TermGenie] synonym: "uterine glands set development" EXACT [GOC:TermGenie] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development created_by: cynthia.smith creation_date: 2014-12-04T18:57:21Z [Term] id: GO:1903710 name: spermine transmembrane transport namespace: biological_process def: "The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075] is_a: GO:0000296 ! spermine transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0072488 ! ammonium transmembrane transport is_a: GO:1902047 ! polyamine transmembrane transport created_by: vw creation_date: 2014-12-06T08:11:32Z [Term] id: GO:1903711 name: spermidine transmembrane transport namespace: biological_process def: "The process in which spermidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075] is_a: GO:0015848 ! spermidine transport is_a: GO:0072488 ! ammonium transmembrane transport is_a: GO:1902047 ! polyamine transmembrane transport created_by: vw creation_date: 2014-12-06T08:12:44Z [Term] id: GO:1903712 name: cysteine transmembrane transport namespace: biological_process def: "The directed movement of cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0042883 ! cysteine transport is_a: GO:0098655 ! cation transmembrane transport created_by: vw creation_date: 2014-12-06T08:15:06Z [Term] id: GO:1903713 name: asparagine transmembrane transport namespace: biological_process def: "The directed movement of asparagine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0006867 ! asparagine transport is_a: GO:0098655 ! cation transmembrane transport created_by: vw creation_date: 2014-12-06T08:17:55Z [Term] id: GO:1903714 name: isoleucine transmembrane transport namespace: biological_process def: "The directed movement of isoleucine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015818 ! isoleucine transport is_a: GO:0098655 ! cation transmembrane transport created_by: vw creation_date: 2014-12-06T08:19:05Z [Term] id: GO:1903715 name: regulation of aerobic respiration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aerobic respiration." [GO_REF:0000058, GOC:TermGenie, PMID:19266076] is_a: GO:0043457 ! regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009060 ! aerobic respiration relationship: regulates GO:0009060 ! aerobic respiration created_by: al creation_date: 2014-12-08T00:40:37Z [Term] id: GO:1903716 name: guanine transmembrane transport namespace: biological_process def: "The process in which guanine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:14998997] is_a: GO:0015854 ! guanine transport is_a: GO:1904823 ! purine nucleobase transmembrane transport created_by: vw creation_date: 2014-12-08T12:18:27Z [Term] id: GO:1903717 name: response to ammonia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] is_a: GO:0009636 ! response to toxic substance is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound created_by: ha creation_date: 2014-12-08T14:55:44Z [Term] id: GO:1903718 name: cellular response to ammonia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1903717 ! response to ammonia created_by: ha creation_date: 2014-12-08T14:55:54Z [Term] id: GO:1903719 name: regulation of I-kappaB phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531] synonym: "regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007252 ! I-kappaB phosphorylation relationship: regulates GO:0007252 ! I-kappaB phosphorylation created_by: lb creation_date: 2014-12-08T15:45:07Z [Term] id: GO:1903720 name: negative regulation of I-kappaB phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531] synonym: "down regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "down regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "inhibition of I-kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of IkappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of IKB phosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "inhibition of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "negative regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "negative regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "negative regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "negative regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:1903719 ! regulation of I-kappaB phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007252 ! I-kappaB phosphorylation relationship: negatively_regulates GO:0007252 ! I-kappaB phosphorylation created_by: lb creation_date: 2014-12-08T15:45:16Z [Term] id: GO:1903721 name: positive regulation of I-kappaB phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PubMed:23675531] synonym: "activation of I-kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "activation of IkappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "activation of IKB phosphorylation" NARROW [GOC:TermGenie] synonym: "activation of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "activation of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "positive regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "positive regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "positive regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of IKB phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling is_a: GO:1903719 ! regulation of I-kappaB phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007252 ! I-kappaB phosphorylation relationship: positively_regulates GO:0007252 ! I-kappaB phosphorylation created_by: lb creation_date: 2014-12-08T15:45:25Z [Term] id: GO:1903722 name: regulation of centriole elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] is_a: GO:0046599 ! regulation of centriole replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061511 ! centriole elongation relationship: regulates GO:0061511 ! centriole elongation created_by: als creation_date: 2014-12-09T16:36:02Z [Term] id: GO:1903723 name: negative regulation of centriole elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] synonym: "down regulation of centriole elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of centriole elongation" EXACT [GOC:TermGenie] synonym: "downregulation of centriole elongation" EXACT [GOC:TermGenie] synonym: "inhibition of centriole elongation" NARROW [GOC:TermGenie] is_a: GO:0046600 ! negative regulation of centriole replication is_a: GO:1903722 ! regulation of centriole elongation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061511 ! centriole elongation relationship: negatively_regulates GO:0061511 ! centriole elongation created_by: als creation_date: 2014-12-09T16:36:12Z [Term] id: GO:1903724 name: positive regulation of centriole elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] synonym: "activation of centriole elongation" NARROW [GOC:TermGenie] synonym: "up regulation of centriole elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of centriole elongation" EXACT [GOC:TermGenie] synonym: "upregulation of centriole elongation" EXACT [GOC:TermGenie] is_a: GO:0046601 ! positive regulation of centriole replication is_a: GO:1903722 ! regulation of centriole elongation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061511 ! centriole elongation relationship: positively_regulates GO:0061511 ! centriole elongation created_by: als creation_date: 2014-12-09T16:36:20Z [Term] id: GO:1903725 name: regulation of phospholipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] synonym: "regulation of phospholipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006644 ! phospholipid metabolic process relationship: regulates GO:0006644 ! phospholipid metabolic process created_by: sl creation_date: 2014-12-09T20:49:27Z [Term] id: GO:1903726 name: negative regulation of phospholipid metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] synonym: "down regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of phospholipid metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of phospholipid metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of phospholipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006644 ! phospholipid metabolic process relationship: negatively_regulates GO:0006644 ! phospholipid metabolic process created_by: sl creation_date: 2014-12-09T20:49:35Z [Term] id: GO:1903727 name: positive regulation of phospholipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] synonym: "activation of phospholipid metabolic process" NARROW [GOC:TermGenie] synonym: "activation of phospholipid metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipid metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipid metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0045937 ! positive regulation of phosphate metabolic process is_a: GO:1903725 ! regulation of phospholipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006644 ! phospholipid metabolic process relationship: positively_regulates GO:0006644 ! phospholipid metabolic process created_by: sl creation_date: 2014-12-09T20:49:44Z [Term] id: GO:1903728 name: luteal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." [GO_REF:0000086, GOC:TermGenie, MP:0001133] synonym: "lutein cell differentiation" EXACT [CL:0000175] is_a: GO:0030154 ! cell differentiation created_by: cjm creation_date: 2014-12-10T01:36:43Z [Term] id: GO:1903729 name: regulation of plasma membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007009 ! plasma membrane organization relationship: regulates GO:0007009 ! plasma membrane organization created_by: al creation_date: 2014-12-10T18:59:44Z [Term] id: GO:1903730 name: regulation of phosphatidate phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22334681, PMID:24876385, PMID:25359770] comment: Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity synonym: "regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008195 ! phosphatidate phosphatase activity relationship: part_of GO:0010866 ! regulation of triglyceride biosynthetic process relationship: part_of GO:0071071 ! regulation of phospholipid biosynthetic process relationship: regulates GO:0008195 ! phosphatidate phosphatase activity created_by: rn creation_date: 2014-12-11T21:29:55Z [Term] id: GO:1903740 name: positive regulation of phosphatidate phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:25359770] synonym: "activation of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidate phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008195 ! phosphatidate phosphatase activity relationship: part_of GO:0010867 ! positive regulation of triglyceride biosynthetic process relationship: part_of GO:0071073 ! positive regulation of phospholipid biosynthetic process relationship: positively_regulates GO:0008195 ! phosphatidate phosphatase activity created_by: tb creation_date: 2014-12-11T23:37:44Z [Term] id: GO:1903741 name: negative regulation of phosphatidate phosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:22334681] synonym: "down regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidate phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008195 ! phosphatidate phosphatase activity relationship: negatively_regulates GO:0008195 ! phosphatidate phosphatase activity relationship: part_of GO:0010868 ! negative regulation of triglyceride biosynthetic process relationship: part_of GO:0071072 ! negative regulation of phospholipid biosynthetic process created_by: tb creation_date: 2014-12-11T23:37:54Z [Term] id: GO:1903742 name: regulation of anterograde synaptic vesicle transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] subset: goslim_synapse is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1902803 ! regulation of synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048490 ! anterograde synaptic vesicle transport relationship: regulates GO:0048490 ! anterograde synaptic vesicle transport created_by: kmv creation_date: 2014-12-12T16:28:27Z [Term] id: GO:1903743 name: negative regulation of anterograde synaptic vesicle transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] synonym: "down regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "downregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "inhibition of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1902804 ! negative regulation of synaptic vesicle transport is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport relationship: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport created_by: kmv creation_date: 2014-12-12T16:28:37Z [Term] id: GO:1903744 name: positive regulation of anterograde synaptic vesicle transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] synonym: "activation of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie] synonym: "up regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] synonym: "upregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1902805 ! positive regulation of synaptic vesicle transport is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport relationship: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport created_by: kmv creation_date: 2014-12-12T16:28:46Z [Term] id: GO:1903745 name: negative regulation of pharyngeal pumping namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] synonym: "down regulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "down regulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "down-regulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "down-regulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "downregulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "downregulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "inhibition of pharyngeal pumping" NARROW [GOC:TermGenie] synonym: "inhibition of pumping behavior" RELATED [GOC:TermGenie] synonym: "negative regulation of pumping behavior" RELATED [GOC:TermGenie] is_a: GO:0043051 ! regulation of pharyngeal pumping is_a: GO:1903999 ! negative regulation of eating behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043050 ! pharyngeal pumping relationship: negatively_regulates GO:0043050 ! pharyngeal pumping created_by: kmv creation_date: 2014-12-12T17:10:59Z [Term] id: GO:1903746 name: positive regulation of pharyngeal pumping namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] synonym: "activation of pharyngeal pumping" NARROW [GOC:TermGenie] synonym: "activation of pumping behavior" RELATED [GOC:TermGenie] synonym: "positive regulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "up regulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "up regulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "up-regulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "up-regulation of pumping behavior" RELATED [GOC:TermGenie] synonym: "upregulation of pharyngeal pumping" EXACT [GOC:TermGenie] synonym: "upregulation of pumping behavior" RELATED [GOC:TermGenie] is_a: GO:0043051 ! regulation of pharyngeal pumping is_a: GO:1904000 ! positive regulation of eating behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043050 ! pharyngeal pumping relationship: positively_regulates GO:0043050 ! pharyngeal pumping created_by: kmv creation_date: 2014-12-12T17:11:09Z [Term] id: GO:1903747 name: regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072655 ! establishment of protein localization to mitochondrion relationship: regulates GO:0072655 ! establishment of protein localization to mitochondrion created_by: krc creation_date: 2014-12-12T22:18:09Z [Term] id: GO:1903748 name: negative regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion relationship: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion created_by: krc creation_date: 2014-12-12T22:18:18Z [Term] id: GO:1903749 name: positive regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion relationship: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion created_by: krc creation_date: 2014-12-12T22:18:26Z [Term] id: GO:1903750 name: regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] synonym: "regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of hydrogen peroxide-induced apoptosis" BROAD [GOC:TermGenie] synonym: "regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide created_by: krc creation_date: 2014-12-12T23:04:28Z [Term] id: GO:1903751 name: negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] synonym: "down regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "down-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "downregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "inhibition of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "negative regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] is_a: GO:1901299 ! negative regulation of hydrogen peroxide-mediated programmed cell death is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide created_by: krc creation_date: 2014-12-12T23:04:37Z [Term] id: GO:1903752 name: positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] synonym: "activation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "positive regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "up regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "up-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "upregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] is_a: GO:1901300 ! positive regulation of hydrogen peroxide-mediated programmed cell death is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide relationship: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide created_by: krc creation_date: 2014-12-12T23:04:46Z [Term] id: GO:1903753 name: negative regulation of p38MAPK cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] synonym: "down regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "down regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "down regulation of p38MAPK cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of p38MAPK cascade" EXACT [GOC:TermGenie] synonym: "downregulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "downregulation of p38 MAPK cascade" EXACT [GOC:TermGenie] synonym: "downregulation of p38MAPK cascade" EXACT [GOC:TermGenie] synonym: "inhibition of p38 cascade" NARROW [GOC:TermGenie] synonym: "inhibition of p38 MAPK cascade" NARROW [GOC:TermGenie] synonym: "inhibition of p38MAPK cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of p38 cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade is_a: GO:1900744 ! regulation of p38MAPK cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038066 ! p38MAPK cascade relationship: negatively_regulates GO:0038066 ! p38MAPK cascade created_by: krc creation_date: 2014-12-12T23:09:26Z [Term] id: GO:1903754 name: cortical microtubule plus-end namespace: cellular_component def: "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw] synonym: "cortical microtubule plus end" EXACT [] is_a: GO:1904511 ! cytoplasmic microtubule plus-end intersection_of: GO:0035371 ! microtubule plus-end intersection_of: part_of GO:0055028 ! cortical microtubule relationship: part_of GO:0055028 ! cortical microtubule created_by: jl creation_date: 2014-12-16T15:41:38Z [Term] id: GO:1903755 name: positive regulation of SUMO transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of SUMO transferase activity." [GO_REF:0000059, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:19955185] synonym: "activation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] synonym: "activation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] synonym: "activation of SUMO transferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] synonym: "positive regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] synonym: "up regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] synonym: "up regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] synonym: "up regulation of SUMO transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] synonym: "up-regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] synonym: "up-regulation of SUMO transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] synonym: "upregulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] synonym: "upregulation of SUMO transferase activity" EXACT [GOC:TermGenie] is_a: GO:0033235 ! positive regulation of protein sumoylation is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1903182 ! regulation of SUMO transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019789 ! SUMO transferase activity relationship: positively_regulates GO:0019789 ! SUMO transferase activity created_by: rl creation_date: 2014-12-18T13:05:59Z [Term] id: GO:1903759 name: signal transduction involved in regulation of aerobic respiration namespace: biological_process def: "Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076] synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:1903715 ! regulation of aerobic respiration relationship: part_of GO:1903715 ! regulation of aerobic respiration created_by: al creation_date: 2014-12-18T16:37:50Z [Term] id: GO:1903760 name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] synonym: "regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization relationship: regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization created_by: rl creation_date: 2014-12-19T12:01:59Z [Term] id: GO:1903761 name: negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] synonym: "down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity is_a: GO:1905025 ! negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization relationship: negatively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization created_by: rl creation_date: 2014-12-19T12:02:09Z [Term] id: GO:1903762 name: positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] synonym: "activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity is_a: GO:1905026 ! positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization relationship: positively_regulates GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization created_by: rl creation_date: 2014-12-19T12:02:18Z [Term] id: GO:1903763 name: gap junction channel activity involved in cell communication by electrical coupling namespace: molecular_function def: "Any gap junction channel activity that is involved in cell communication by electrical coupling." [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307] synonym: "connexin involved in cell communication by electrical coupling" RELATED [GOC:TermGenie] synonym: "innexin channel activity involved in cell communication by electrical coupling" EXACT [GOC:TermGenie] synonym: "innexin involved in cell communication by electrical coupling" NARROW [GOC:TermGenie] is_a: GO:0005243 ! gap junction channel activity intersection_of: GO:0005243 ! gap junction channel activity intersection_of: part_of GO:0010644 ! cell communication by electrical coupling relationship: part_of GO:0010644 ! cell communication by electrical coupling created_by: rl creation_date: 2014-12-19T15:43:16Z [Term] id: GO:1903764 name: regulation of potassium ion export across plasma membrane namespace: biological_process alt_id: GO:1902302 def: "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "regulation of potassium export" BROAD [GOC:TermGenie] synonym: "regulation of potassium export across plasma membrane" BROAD [GOC:TermGenie] synonym: "regulation of potassium ion export" BROAD [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1901379 ! regulation of potassium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097623 ! potassium ion export across plasma membrane relationship: regulates GO:0097623 ! potassium ion export across plasma membrane created_by: rl creation_date: 2013-07-17T16:39:53Z [Term] id: GO:1903765 name: negative regulation of potassium ion export across plasma membrane namespace: biological_process alt_id: GO:1902303 def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "down regulation of potassium export" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "down regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of potassium export" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "down-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of potassium export" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "downregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of potassium export" NARROW [GOC:TermGenie] synonym: "inhibition of potassium ion export" RELATED [GOC:TermGenie] synonym: "inhibition of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of potassium export" BROAD [GOC:TermGenie] synonym: "negative regulation of potassium ion export" BROAD [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane relationship: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane created_by: rl creation_date: 2013-07-17T16:40:02Z [Term] id: GO:1903766 name: positive regulation of potassium ion export across plasma membrane namespace: biological_process alt_id: GO:1902304 def: "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] synonym: "activation of potassium export" RELATED [GOC:TermGenie] synonym: "activation of potassium ion export" RELATED [GOC:TermGenie] synonym: "activation of potassium ion export across plasma membrane" RELATED [GOC:TermGenie] synonym: "positive regulation of potassium export" BROAD [GOC:TermGenie] synonym: "positive regulation of potassium ion export" BROAD [] synonym: "up regulation of potassium export" BROAD [GOC:TermGenie] synonym: "up regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "up regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of potassium export" BROAD [GOC:TermGenie] synonym: "up-regulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "up-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of potassium export" BROAD [GOC:TermGenie] synonym: "upregulation of potassium ion export" BROAD [GOC:TermGenie] synonym: "upregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097623 ! potassium ion export across plasma membrane relationship: positively_regulates GO:0097623 ! potassium ion export across plasma membrane created_by: rl creation_date: 2013-07-17T16:40:10Z [Term] id: GO:1903767 name: sweet taste receptor complex namespace: cellular_component def: "A protein complex which is capable of sweet taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576] is_a: GO:1903768 ! taste receptor complex created_by: rl creation_date: 2014-12-22T16:49:24Z [Term] id: GO:1903768 name: taste receptor complex namespace: cellular_component def: "A protein complex which is capable of taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576] is_a: GO:0043235 ! receptor complex created_by: rl creation_date: 2014-12-22T16:53:45Z [Term] id: GO:1903769 name: negative regulation of cell proliferation in bone marrow namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow." [GO_REF:0000058, GOC:TermGenie, PMID:9241534] synonym: "down regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] synonym: "down-regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] synonym: "downregulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] synonym: "inhibition of bone marrow cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation in bone marrow" NARROW [GOC:TermGenie] synonym: "negative regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0071863 ! regulation of cell proliferation in bone marrow intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071838 ! cell proliferation in bone marrow relationship: negatively_regulates GO:0071838 ! cell proliferation in bone marrow created_by: sl creation_date: 2014-12-29T19:46:26Z [Term] id: GO:1903770 name: negative regulation of beta-galactosidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518] synonym: "down regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "down regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "down regulation of lactozym" RELATED [GOC:TermGenie] synonym: "down regulation of maxilact" RELATED [GOC:TermGenie] synonym: "down regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "down regulation of S 2107" RELATED [GOC:TermGenie] synonym: "down regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "down regulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "down-regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "down-regulation of lactozym" RELATED [GOC:TermGenie] synonym: "down-regulation of maxilact" RELATED [GOC:TermGenie] synonym: "down-regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "down-regulation of S 2107" RELATED [GOC:TermGenie] synonym: "down-regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "down-regulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrolact" RELATED [GOC:TermGenie] synonym: "downregulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "downregulation of lactozym" RELATED [GOC:TermGenie] synonym: "downregulation of maxilact" RELATED [GOC:TermGenie] synonym: "downregulation of oryzatym" RELATED [GOC:TermGenie] synonym: "downregulation of S 2107" RELATED [GOC:TermGenie] synonym: "downregulation of sumiklat" RELATED [GOC:TermGenie] synonym: "downregulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "inhibition of beta-D-galactanase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-D-lactosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-galactosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-lactosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrolact" RELATED [GOC:TermGenie] synonym: "inhibition of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "inhibition of lactozym" RELATED [GOC:TermGenie] synonym: "inhibition of maxilact" RELATED [GOC:TermGenie] synonym: "inhibition of oryzatym" RELATED [GOC:TermGenie] synonym: "inhibition of S 2107" RELATED [GOC:TermGenie] synonym: "inhibition of sumiklat" RELATED [GOC:TermGenie] synonym: "inhibition of trilactase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "negative regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "negative regulation of lactozym" RELATED [GOC:TermGenie] synonym: "negative regulation of maxilact" RELATED [GOC:TermGenie] synonym: "negative regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "negative regulation of S 2107" RELATED [GOC:TermGenie] synonym: "negative regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "negative regulation of trilactase activity" EXACT [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004565 ! beta-galactosidase activity relationship: negatively_regulates GO:0004565 ! beta-galactosidase activity created_by: nc creation_date: 2015-01-06T10:53:22Z [Term] id: GO:1903771 name: positive regulation of beta-galactosidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518] synonym: "activation of beta-D-galactanase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-D-lactosidase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-galactosidase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-lactosidase activity" NARROW [GOC:TermGenie] synonym: "activation of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrolact" RELATED [GOC:TermGenie] synonym: "activation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "activation of lactozym" RELATED [GOC:TermGenie] synonym: "activation of maxilact" RELATED [GOC:TermGenie] synonym: "activation of oryzatym" RELATED [GOC:TermGenie] synonym: "activation of S 2107" RELATED [GOC:TermGenie] synonym: "activation of sumiklat" RELATED [GOC:TermGenie] synonym: "activation of trilactase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "positive regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "positive regulation of lactozym" RELATED [GOC:TermGenie] synonym: "positive regulation of maxilact" RELATED [GOC:TermGenie] synonym: "positive regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "positive regulation of S 2107" RELATED [GOC:TermGenie] synonym: "positive regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "positive regulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "up regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "up regulation of lactozym" RELATED [GOC:TermGenie] synonym: "up regulation of maxilact" RELATED [GOC:TermGenie] synonym: "up regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "up regulation of S 2107" RELATED [GOC:TermGenie] synonym: "up regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "up regulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrolact" RELATED [GOC:TermGenie] synonym: "up-regulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "up-regulation of lactozym" RELATED [GOC:TermGenie] synonym: "up-regulation of maxilact" RELATED [GOC:TermGenie] synonym: "up-regulation of oryzatym" RELATED [GOC:TermGenie] synonym: "up-regulation of S 2107" RELATED [GOC:TermGenie] synonym: "up-regulation of sumiklat" RELATED [GOC:TermGenie] synonym: "up-regulation of trilactase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-galactosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-lactosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrolact" RELATED [GOC:TermGenie] synonym: "upregulation of lactose hydrolysis" RELATED [GOC:TermGenie] synonym: "upregulation of lactozym" RELATED [GOC:TermGenie] synonym: "upregulation of maxilact" RELATED [GOC:TermGenie] synonym: "upregulation of oryzatym" RELATED [GOC:TermGenie] synonym: "upregulation of S 2107" RELATED [GOC:TermGenie] synonym: "upregulation of sumiklat" RELATED [GOC:TermGenie] synonym: "upregulation of trilactase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004565 ! beta-galactosidase activity relationship: positively_regulates GO:0004565 ! beta-galactosidase activity created_by: nc creation_date: 2015-01-06T10:53:32Z [Term] id: GO:1903772 name: regulation of viral budding via host ESCRT complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] synonym: "regulation of host-assisted viral budding" BROAD [GOC:TermGenie] synonym: "regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0039702 ! viral budding via host ESCRT complex relationship: regulates GO:0039702 ! viral budding via host ESCRT complex created_by: als creation_date: 2015-01-06T16:20:43Z [Term] id: GO:1903773 name: negative regulation of viral budding via host ESCRT complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] synonym: "down regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "down regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] synonym: "down-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "down-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] synonym: "downregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "downregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] synonym: "inhibition of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "inhibition of viral budding via host ESCRT complex" NARROW [GOC:TermGenie] synonym: "negative regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex is_a: GO:1903901 ! negative regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex relationship: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex created_by: als creation_date: 2015-01-06T16:20:53Z [Term] id: GO:1903774 name: positive regulation of viral budding via host ESCRT complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] synonym: "activation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "activation of viral budding via host ESCRT complex" NARROW [GOC:TermGenie] synonym: "positive regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "up regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "up regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] synonym: "up-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "up-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] synonym: "upregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] synonym: "upregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex is_a: GO:1903902 ! positive regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0039702 ! viral budding via host ESCRT complex relationship: positively_regulates GO:0039702 ! viral budding via host ESCRT complex created_by: als creation_date: 2015-01-06T16:21:02Z [Term] id: GO:1903775 name: regulation of DNA double-strand break processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000729 ! DNA double-strand break processing relationship: regulates GO:0000729 ! DNA double-strand break processing created_by: al creation_date: 2015-01-06T17:08:15Z [Term] id: GO:1903776 name: regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends relationship: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends created_by: al creation_date: 2015-01-06T17:08:24Z [Term] id: GO:1903777 name: melibiose binding namespace: molecular_function def: "Interacting selectively and non-covalently with melibiose." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:11471732] is_a: GO:0048030 ! disaccharide binding created_by: mr creation_date: 2015-01-06T21:05:29Z [Term] id: GO:1903778 name: protein localization to vacuolar membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072665 ! protein localization to vacuole created_by: mah creation_date: 2015-01-07T13:15:54Z [Term] id: GO:1903779 name: regulation of cardiac conduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061337 ! cardiac conduction relationship: regulates GO:0061337 ! cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:11Z [Term] id: GO:1903780 name: negative regulation of cardiac conduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie] is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061337 ! cardiac conduction relationship: negatively_regulates GO:0061337 ! cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:20Z [Term] id: GO:1903781 name: positive regulation of cardiac conduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie] is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061337 ! cardiac conduction relationship: positively_regulates GO:0061337 ! cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:28Z [Term] id: GO:1903782 name: regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098719 ! sodium ion import across plasma membrane relationship: regulates GO:0098719 ! sodium ion import across plasma membrane created_by: nc creation_date: 2015-01-07T16:48:43Z [Term] id: GO:1903783 name: negative regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] synonym: "down regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane relationship: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane created_by: nc creation_date: 2015-01-07T16:48:51Z [Term] id: GO:1903784 name: positive regulation of sodium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] synonym: "activation of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] synonym: "up regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098719 ! sodium ion import across plasma membrane relationship: positively_regulates GO:0098719 ! sodium ion import across plasma membrane created_by: nc creation_date: 2015-01-07T16:49:00Z [Term] id: GO:1903785 name: L-valine transmembrane transport namespace: biological_process def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015829 ! valine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: al creation_date: 2015-01-08T14:50:32Z [Term] id: GO:1903786 name: regulation of glutathione biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006750 ! glutathione biosynthetic process relationship: regulates GO:0006750 ! glutathione biosynthetic process created_by: bf creation_date: 2015-01-08T17:14:49Z [Term] id: GO:1903787 name: negative regulation of glutathione biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "down regulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "down-regulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "downregulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of glutathione anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of glutathione biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of glutathione biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of glutathione formation" NARROW [GOC:TermGenie] synonym: "inhibition of glutathione synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1903786 ! regulation of glutathione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006750 ! glutathione biosynthetic process relationship: negatively_regulates GO:0006750 ! glutathione biosynthetic process created_by: bf creation_date: 2015-01-08T17:14:59Z [Term] id: GO:1903788 name: positive regulation of glutathione biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of glutathione anabolism" NARROW [GOC:TermGenie] synonym: "activation of glutathione biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of glutathione biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of glutathione formation" NARROW [GOC:TermGenie] synonym: "activation of glutathione synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "positive regulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "up regulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "up-regulation of glutathione synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione formation" EXACT [GOC:TermGenie] synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1903786 ! regulation of glutathione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006750 ! glutathione biosynthetic process relationship: positively_regulates GO:0006750 ! glutathione biosynthetic process created_by: bf creation_date: 2015-01-08T17:15:07Z [Term] id: GO:1903789 name: regulation of amino acid transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003333 ! amino acid transmembrane transport relationship: regulates GO:0003333 ! amino acid transmembrane transport created_by: al creation_date: 2015-01-08T17:42:18Z [Term] id: GO:1903790 name: guanine nucleotide transmembrane transport namespace: biological_process def: "The process in which a guanyl nucleotide is transported across a membrane." [GO_REF:0000069, GOC:dph, GOC:TermGenie, GOC:vw, PMID:25320081] synonym: "guanyl nucleotide transmembrane transport" EXACT [] is_a: GO:0001408 ! guanine nucleotide transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: dph creation_date: 2015-01-10T13:51:54Z [Term] id: GO:1903791 name: uracil transmembrane transport namespace: biological_process def: "The process in which uracil is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015857 ! uracil transport is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport created_by: vw creation_date: 2015-01-12T10:15:25Z [Term] id: GO:1903792 name: negative regulation of anion transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "down regulation of anion transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "downregulation of anion transport" EXACT [GOC:TermGenie] synonym: "inhibition of anion transport" NARROW [GOC:TermGenie] is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006820 ! anion transport relationship: negatively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:20Z [Term] id: GO:1903793 name: positive regulation of anion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "activation of anion transport" NARROW [GOC:TermGenie] synonym: "up regulation of anion transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie] synonym: "upregulation of anion transport" EXACT [GOC:TermGenie] is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006820 ! anion transport relationship: positively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:30Z [Term] id: GO:1903794 name: cortisol binding namespace: molecular_function def: "Interacting selectively and non-covalently with cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153] is_a: GO:0008144 ! drug binding is_a: GO:0043178 ! alcohol binding is_a: GO:1990239 ! steroid hormone binding created_by: mr creation_date: 2015-01-14T19:02:31Z [Term] id: GO:1903795 name: regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098661 ! inorganic anion transmembrane transport relationship: regulates GO:0098661 ! inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:44:49Z [Term] id: GO:1903796 name: negative regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:44:59Z [Term] id: GO:1903797 name: positive regulation of inorganic anion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098661 ! inorganic anion transmembrane transport relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport created_by: sl creation_date: 2015-01-14T21:45:08Z [Term] id: GO:1903798 name: regulation of production of miRNAs involved in gene silencing by miRNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "regulation of microRNA processing" BROAD [GOC:TermGenie] synonym: "regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] is_a: GO:0060964 ! regulation of gene silencing by miRNA is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA relationship: regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA created_by: rph creation_date: 2015-01-15T13:58:12Z [Term] id: GO:1903799 name: negative regulation of production of miRNAs involved in gene silencing by miRNA namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "down regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "down regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "down regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "down regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "down regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "down regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "down regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "down regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "down-regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "down-regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "down-regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "down-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "down-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "downregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "downregulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "downregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "downregulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "downregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "downregulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "downregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "downregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "downregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "inhibition of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie] synonym: "inhibition of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "inhibition of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "inhibition of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "inhibition of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie] synonym: "inhibition of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of miRNA processing" NARROW [GOC:TermGenie] synonym: "inhibition of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie] synonym: "inhibition of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie] synonym: "inhibition of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "negative regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "negative regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "negative regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "negative regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "negative regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "negative regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:0060965 ! negative regulation of gene silencing by miRNA is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA relationship: negatively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA created_by: rph creation_date: 2015-01-15T13:58:22Z [Term] id: GO:1903800 name: positive regulation of production of miRNAs involved in gene silencing by miRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie] synonym: "activation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "activation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "activation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "activation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "activation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "activation of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie] synonym: "activation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "activation of miRNA processing" NARROW [GOC:TermGenie] synonym: "activation of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie] synonym: "activation of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie] synonym: "activation of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "positive regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "positive regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "positive regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "positive regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "positive regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "positive regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "up regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "up regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "up regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "up regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "up regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "up regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "up regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "up regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "up regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "up-regulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "up-regulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "up-regulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "up-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "up-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "upregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] synonym: "upregulation of microRNA biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of microRNA biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] synonym: "upregulation of microRNA metabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of microRNA metabolism" RELATED [GOC:TermGenie] synonym: "upregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] synonym: "upregulation of miRNA biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of miRNA processing" EXACT [GOC:TermGenie] synonym: "upregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] synonym: "upregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "upregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA is_a: GO:2000637 ! positive regulation of gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA relationship: positively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA created_by: rph creation_date: 2015-01-15T13:58:31Z [Term] id: GO:1903801 name: L-leucine import across plasma membrane namespace: biological_process alt_id: GO:0060356 def: "The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-leucine import" BROAD [] synonym: "L-leucine import into cell" EXACT [] synonym: "L-leucine uptake" NARROW [] synonym: "leucine import" BROAD [] synonym: "leucine uptake" EXACT [] is_a: GO:0098713 ! leucine import across plasma membrane is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: mah creation_date: 2015-01-16T14:34:46Z [Term] id: GO:1903803 name: L-glutamine import across plasma membrane namespace: biological_process alt_id: GO:0036229 def: "The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-glutamine import" BROAD [] synonym: "L-glutamine import into cell" EXACT [] synonym: "L-glutamine uptake" EXACT [GOC:bf] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0006868 ! glutamine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:1903804 name: glycine import across plasma membrane namespace: biological_process alt_id: GO:0036233 def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "glycine import" BROAD [] synonym: "glycine import into cell" EXACT [] is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: rfoulger creation_date: 2012-05-11T01:16:45Z [Term] id: GO:1903805 name: L-valine import across plasma membrane namespace: biological_process alt_id: GO:0090468 def: "The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-valine import into cell" EXACT [] synonym: "valine import" NARROW [] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1903785 ! L-valine transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:1903806 name: L-isoleucine import across plasma membrane namespace: biological_process alt_id: GO:0090476 alt_id: GO:0090477 def: "The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "isoleucine import" BROAD [] synonym: "L-isoleucine import" BROAD [] synonym: "L-isoleucine import into cell" EXACT [] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903714 ! isoleucine transmembrane transport created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:1903807 name: L-threonine import across plasma membrane namespace: biological_process alt_id: GO:0036231 def: "The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-threonine import" BROAD [] synonym: "L-threonine import into cell" EXACT [] synonym: "L-threonine uptake" EXACT [GOC:bf] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015826 ! threonine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:1903808 name: L-tyrosine import across plasma membrane namespace: biological_process alt_id: GO:0036232 def: "The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-tyrosine import" BROAD [] synonym: "L-tyrosine import into cell" EXACT [] synonym: "L-tyrosine uptake" EXACT [GOC:bf] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015828 ! tyrosine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:1903810 name: L-histidine import across plasma membrane namespace: biological_process alt_id: GO:0061460 alt_id: GO:0090466 def: "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "histidine import" BROAD [] synonym: "L-histidine import" BROAD [] synonym: "L-histidine import into cell" EXACT [] is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane created_by: dph creation_date: 2012-10-05T10:20:50Z [Term] id: GO:1903811 name: L-asparagine import across plasma membrane namespace: biological_process alt_id: GO:0090469 def: "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "asparagine import" BROAD [] synonym: "L-asparagine import into cell" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903713 ! asparagine transmembrane transport created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:1903812 name: L-serine import across plasma membrane namespace: biological_process def: "The directed movement of L-serine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "L-serine import into cell" EXACT [] is_a: GO:0015825 ! L-serine transport is_a: GO:0098718 ! serine import across plasma membrane is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: mah creation_date: 2015-01-16T14:36:29Z [Term] id: GO:1903814 name: regulation of collecting lymphatic vessel constriction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] synonym: "regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process is_a: GO:0090066 ! regulation of anatomical structure size intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990192 ! collecting lymphatic vessel constriction relationship: regulates GO:1990192 ! collecting lymphatic vessel constriction created_by: sl creation_date: 2015-01-16T17:01:49Z [Term] id: GO:1903815 name: negative regulation of collecting lymphatic vessel constriction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] synonym: "down regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "down regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "down-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "downregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "downregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "inhibition of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie] synonym: "inhibition of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie] synonym: "negative regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction relationship: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction created_by: sl creation_date: 2015-01-16T17:01:58Z [Term] id: GO:1903816 name: positive regulation of collecting lymphatic vessel constriction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] synonym: "activation of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie] synonym: "activation of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie] synonym: "positive regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "up regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "up regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "up-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] synonym: "upregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] synonym: "upregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction relationship: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction created_by: sl creation_date: 2015-01-16T17:02:08Z [Term] id: GO:1903817 name: negative regulation of voltage-gated potassium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] synonym: "down regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "downregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "inhibition of voltage gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005249 ! voltage-gated potassium channel activity relationship: negatively_regulates GO:0005249 ! voltage-gated potassium channel activity created_by: sl creation_date: 2015-01-16T17:22:08Z [Term] id: GO:1903818 name: positive regulation of voltage-gated potassium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] synonym: "activation of voltage gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005249 ! voltage-gated potassium channel activity relationship: positively_regulates GO:0005249 ! voltage-gated potassium channel activity created_by: sl creation_date: 2015-01-16T17:22:18Z [Term] id: GO:1903819 name: detection of stimulus involved in mitotic cytokinesis checkpoint namespace: biological_process def: "Any detection of stimulus that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "perception of stimulus involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus detection involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072397 ! detection of stimulus involved in cytokinesis checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044878 ! mitotic cytokinesis checkpoint relationship: part_of GO:0044878 ! mitotic cytokinesis checkpoint created_by: jl creation_date: 2015-01-19T15:03:16Z [Term] id: GO:1903820 name: signal transduction involved in mitotic cytokinesis checkpoint namespace: biological_process def: "Any signal transduction that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "signaling cascade involved in mitotic cytokinesis checkpoint" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in mitotic cytokinesis checkpoint" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072398 ! signal transduction involved in cytokinesis checkpoint intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0044878 ! mitotic cytokinesis checkpoint relationship: part_of GO:0044878 ! mitotic cytokinesis checkpoint created_by: jl creation_date: 2015-01-19T15:03:50Z [Term] id: GO:1903821 name: detection of stimulus involved in morphogenesis checkpoint namespace: biological_process def: "Any detection of stimulus that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "detection of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie] synonym: "perception of stimulus involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "perception of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus detection involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus detection involved in septin checkpoint" RELATED [GOC:TermGenie] synonym: "stimulus sensing involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "stimulus sensing involved in septin checkpoint" RELATED [GOC:TermGenie] is_a: GO:0072412 ! detection of stimulus involved in mitotic cell cycle checkpoint intersection_of: GO:0051606 ! detection of stimulus intersection_of: part_of GO:0044879 ! morphogenesis checkpoint relationship: part_of GO:0044879 ! morphogenesis checkpoint created_by: jl creation_date: 2015-01-19T15:03:59Z [Term] id: GO:1903822 name: signal transduction involved in morphogenesis checkpoint namespace: biological_process def: "Any signal transduction that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "signal transduction involved in septin checkpoint" EXACT [GOC:TermGenie] synonym: "signaling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "signaling cascade involved in septin checkpoint" EXACT [GOC:TermGenie] synonym: "signaling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "signaling pathway involved in septin checkpoint" EXACT [GOC:TermGenie] synonym: "signalling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "signalling cascade involved in septin checkpoint" EXACT [GOC:TermGenie] synonym: "signalling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] synonym: "signalling pathway involved in septin checkpoint" EXACT [GOC:TermGenie] is_a: GO:0007165 ! signal transduction is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0044879 ! morphogenesis checkpoint relationship: part_of GO:0044879 ! morphogenesis checkpoint created_by: jl creation_date: 2015-01-19T15:04:08Z [Term] id: GO:1903823 name: telomere single strand break repair namespace: biological_process def: "Single strand break repair that takes place in a telomere." [GO_REF:0000062, GOC:TermGenie, PMID:24374808] synonym: "single strand break repair in telomere" EXACT [GOC:TermGenie] synonym: "telomere single-strand break repair" EXACT [] synonym: "telomere SSBR" RELATED [] synonym: "telomeric single strand break repair" EXACT [] is_a: GO:0000012 ! single strand break repair intersection_of: GO:0000012 ! single strand break repair intersection_of: occurs_in GO:0000781 ! chromosome, telomeric region relationship: occurs_in GO:0000781 ! chromosome, telomeric region created_by: jl creation_date: 2015-01-19T16:12:29Z [Term] id: GO:1903824 name: negative regulation of telomere single strand break repair namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair." [GO_REF:0000058, GOC:TermGenie, PMID:24374808] synonym: "down regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] synonym: "down regulation of telomere single strand break repair" EXACT [GOC:TermGenie] synonym: "down regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] synonym: "down regulation of telomere SSBR" RELATED [GOC:TermGenie] synonym: "down regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] synonym: "down-regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere single strand break repair" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere SSBR" RELATED [GOC:TermGenie] synonym: "down-regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] synonym: "downregulation of single strand break repair in telomere" EXACT [GOC:TermGenie] synonym: "downregulation of telomere single strand break repair" EXACT [GOC:TermGenie] synonym: "downregulation of telomere single-strand break repair" EXACT [GOC:TermGenie] synonym: "downregulation of telomere SSBR" RELATED [GOC:TermGenie] synonym: "downregulation of telomeric single strand break repair" EXACT [GOC:TermGenie] synonym: "inhibition of single strand break repair in telomere" NARROW [GOC:TermGenie] synonym: "inhibition of telomere single strand break repair" NARROW [GOC:TermGenie] synonym: "inhibition of telomere single-strand break repair" NARROW [GOC:TermGenie] synonym: "inhibition of telomere SSBR" RELATED [GOC:TermGenie] synonym: "inhibition of telomeric single strand break repair" NARROW [GOC:TermGenie] synonym: "negative regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] synonym: "negative regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] synonym: "negative regulation of telomere SSBR" RELATED [GOC:TermGenie] synonym: "negative regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] is_a: GO:1903517 ! negative regulation of single strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903823 ! telomere single strand break repair relationship: negatively_regulates GO:1903823 ! telomere single strand break repair created_by: jl creation_date: 2015-01-19T16:24:37Z [Term] id: GO:1903825 name: organic acid transmembrane transport namespace: biological_process def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0015849 ! organic acid transport is_a: GO:0055085 ! transmembrane transport created_by: vw creation_date: 2015-01-20T10:20:58Z [Term] id: GO:1903826 name: arginine transmembrane transport namespace: biological_process def: "The directed movement of arginine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18357653] is_a: GO:0015809 ! arginine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1990822 ! basic amino acid transmembrane transport created_by: vw creation_date: 2015-01-20T10:38:15Z [Term] id: GO:1903827 name: regulation of cellular protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034613 ! cellular protein localization relationship: regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:1903828 name: negative regulation of cellular protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of channel localizer activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034613 ! cellular protein localization relationship: negatively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of cellular protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "activation of cellular protein localization" NARROW [GOC:TermGenie] synonym: "activation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of channel localizer activity" NARROW [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of channel localizer activity" NARROW [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034613 ! cellular protein localization relationship: positively_regulates GO:0034613 ! cellular protein localization created_by: jl creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1903830 name: magnesium ion transmembrane transport namespace: biological_process def: "The directed movement of magnesium ion across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11254124] is_a: GO:0015693 ! magnesium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport created_by: mcc creation_date: 2015-01-21T17:38:30Z [Term] id: GO:1903831 name: signal transduction involved in cellular response to ammonium ion namespace: biological_process def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994] synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: part_of GO:0071242 ! cellular response to ammonium ion relationship: part_of GO:0071242 ! cellular response to ammonium ion created_by: al creation_date: 2015-01-21T17:52:09Z [Term] id: GO:1903832 name: regulation of cellular response to amino acid starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034198 ! cellular response to amino acid starvation relationship: regulates GO:0034198 ! cellular response to amino acid starvation created_by: rn creation_date: 2015-01-21T18:44:28Z [Term] id: GO:1903833 name: positive regulation of cellular response to amino acid starvation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840] synonym: "activation of cellular response to amino acid starvation" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:1903832 ! regulation of cellular response to amino acid starvation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034198 ! cellular response to amino acid starvation relationship: positively_regulates GO:0034198 ! cellular response to amino acid starvation created_by: rn creation_date: 2015-01-21T18:44:37Z [Term] id: GO:1903837 name: regulation of mRNA 3'-UTR binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] synonym: "regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] is_a: GO:1902415 ! regulation of mRNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003730 ! mRNA 3'-UTR binding relationship: regulates GO:0003730 ! mRNA 3'-UTR binding created_by: als creation_date: 2015-01-22T11:53:59Z [Term] id: GO:1903838 name: negative regulation of mRNA 3'-UTR binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] synonym: "down regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] synonym: "inhibition of mRNA 3' UTR binding" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA 3'-UTR binding" NARROW [GOC:TermGenie] synonym: "negative regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding is_a: GO:1904572 ! negative regulation of mRNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003730 ! mRNA 3'-UTR binding relationship: negatively_regulates GO:0003730 ! mRNA 3'-UTR binding created_by: als creation_date: 2015-01-22T11:54:08Z [Term] id: GO:1903839 name: positive regulation of mRNA 3'-UTR binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] synonym: "activation of mRNA 3' UTR binding" NARROW [GOC:TermGenie] synonym: "activation of mRNA 3'-UTR binding" NARROW [GOC:TermGenie] synonym: "positive regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] is_a: GO:1902416 ! positive regulation of mRNA binding is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003730 ! mRNA 3'-UTR binding relationship: positively_regulates GO:0003730 ! mRNA 3'-UTR binding created_by: als creation_date: 2015-01-22T11:54:17Z [Term] id: GO:1903840 name: response to arsenite(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] is_a: GO:0001101 ! response to acid chemical is_a: GO:1903842 ! response to arsenite ion created_by: mr creation_date: 2015-01-22T19:49:25Z [Term] id: GO:1903841 name: cellular response to arsenite(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1903840 ! response to arsenite(3-) is_a: GO:1903843 ! cellular response to arsenite ion created_by: mr creation_date: 2015-01-22T19:49:35Z [Term] id: GO:1903842 name: response to arsenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] is_a: GO:0010035 ! response to inorganic substance is_a: GO:0046685 ! response to arsenic-containing substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: mr creation_date: 2015-01-22T19:56:05Z [Term] id: GO:1903843 name: cellular response to arsenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] is_a: GO:0071243 ! cellular response to arsenic-containing substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903842 ! response to arsenite ion created_by: mr creation_date: 2015-01-22T19:56:14Z [Term] id: GO:1903844 name: regulation of cellular response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus relationship: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus created_by: rph creation_date: 2015-01-23T11:25:11Z [Term] id: GO:1903845 name: negative regulation of cellular response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus relationship: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus created_by: rph creation_date: 2015-01-23T11:25:21Z [Term] id: GO:1903846 name: positive regulation of cellular response to transforming growth factor beta stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie] synonym: "activation of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie] synonym: "activation of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus relationship: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus created_by: rph creation_date: 2015-01-23T11:25:30Z [Term] id: GO:1903847 name: regulation of aorta morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035909 ! aorta morphogenesis relationship: regulates GO:0035909 ! aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:00:51Z [Term] id: GO:1903848 name: negative regulation of aorta morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905652 ! negative regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035909 ! aorta morphogenesis relationship: negatively_regulates GO:0035909 ! aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:01:01Z [Term] id: GO:1903849 name: positive regulation of aorta morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905653 ! positive regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035909 ! aorta morphogenesis relationship: positively_regulates GO:0035909 ! aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:01:09Z [Term] id: GO:1903850 name: regulation of cristae formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype is_a: GO:0010821 ! regulation of mitochondrion organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042407 ! cristae formation relationship: regulates GO:0042407 ! cristae formation created_by: pad creation_date: 2015-01-27T09:42:23Z [Term] id: GO:1903851 name: negative regulation of cristae formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype synonym: "down regulation of cristae formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cristae formation" EXACT [GOC:TermGenie] synonym: "downregulation of cristae formation" EXACT [GOC:TermGenie] synonym: "inhibition of cristae formation" NARROW [GOC:TermGenie] is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:1903850 ! regulation of cristae formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042407 ! cristae formation relationship: negatively_regulates GO:0042407 ! cristae formation created_by: pad creation_date: 2015-01-27T09:42:33Z [Term] id: GO:1903852 name: positive regulation of cristae formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype synonym: "activation of cristae formation" NARROW [GOC:TermGenie] synonym: "up regulation of cristae formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cristae formation" EXACT [GOC:TermGenie] synonym: "upregulation of cristae formation" EXACT [GOC:TermGenie] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:1903850 ! regulation of cristae formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042407 ! cristae formation relationship: positively_regulates GO:0042407 ! cristae formation created_by: pad creation_date: 2015-01-27T09:42:42Z [Term] id: GO:1903853 name: regulation of stress response to copper ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] synonym: "regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "regulation of stress response to copper" BROAD [GOC:TermGenie] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990169 ! stress response to copper ion relationship: regulates GO:1990169 ! stress response to copper ion created_by: kmv creation_date: 2015-01-29T20:15:23Z [Term] id: GO:1903854 name: negative regulation of stress response to copper ion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] synonym: "down regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "down regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "down regulation of stress response to copper ion" EXACT [GOC:TermGenie] synonym: "down-regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "down-regulation of stress response to copper ion" EXACT [GOC:TermGenie] synonym: "downregulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "downregulation of stress response to copper ion" EXACT [GOC:TermGenie] synonym: "inhibition of response to copper ion stress" NARROW [GOC:TermGenie] synonym: "inhibition of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "inhibition of stress response to copper ion" NARROW [GOC:TermGenie] synonym: "negative regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "negative regulation of response to copper toxicity" RELATED [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1903853 ! regulation of stress response to copper ion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990169 ! stress response to copper ion relationship: negatively_regulates GO:1990169 ! stress response to copper ion created_by: kmv creation_date: 2015-01-29T20:15:33Z [Term] id: GO:1903855 name: positive regulation of stress response to copper ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] synonym: "activation of response to copper ion stress" NARROW [GOC:TermGenie] synonym: "activation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "activation of stress response to copper ion" NARROW [GOC:TermGenie] synonym: "positive regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "positive regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "up regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "up regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "up regulation of stress response to copper ion" EXACT [GOC:TermGenie] synonym: "up-regulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "up-regulation of stress response to copper ion" EXACT [GOC:TermGenie] synonym: "upregulation of response to copper ion stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to copper toxicity" RELATED [GOC:TermGenie] synonym: "upregulation of stress response to copper ion" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1903853 ! regulation of stress response to copper ion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990169 ! stress response to copper ion relationship: positively_regulates GO:1990169 ! stress response to copper ion created_by: kmv creation_date: 2015-01-29T20:15:42Z [Term] id: GO:1903856 name: regulation of cytokinin dehydrogenase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363] synonym: "regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019139 ! cytokinin dehydrogenase activity relationship: regulates GO:0019139 ! cytokinin dehydrogenase activity created_by: tb creation_date: 2015-01-30T00:33:51Z [Term] id: GO:1903857 name: negative regulation of cytokinin dehydrogenase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363] synonym: "down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytokinin dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1903856 ! regulation of cytokinin dehydrogenase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019139 ! cytokinin dehydrogenase activity relationship: negatively_regulates GO:0019139 ! cytokinin dehydrogenase activity created_by: tb creation_date: 2015-01-30T00:34:01Z [Term] id: GO:1903858 name: protein localization to old growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:17895368] synonym: "protein localisation in old growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to old growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in old growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1902486 ! protein localization to growing cell tip created_by: mah creation_date: 2015-02-02T13:53:29Z [Term] id: GO:1903859 name: regulation of dendrite extension namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. is_a: GO:0001558 ! regulation of cell growth is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097484 ! dendrite extension relationship: regulates GO:0097484 ! dendrite extension created_by: pad creation_date: 2015-02-02T15:33:51Z [Term] id: GO:1903860 name: negative regulation of dendrite extension namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. synonym: "down regulation of dendrite extension" EXACT [GOC:TermGenie] synonym: "down-regulation of dendrite extension" EXACT [GOC:TermGenie] synonym: "downregulation of dendrite extension" EXACT [GOC:TermGenie] synonym: "inhibition of dendrite extension" NARROW [GOC:TermGenie] synonym: "up regulation of dendrite retraction" EXACT [GOC:pad] synonym: "up-regulation of dendrite retraction" EXACT [GOC:pad] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1903859 ! regulation of dendrite extension intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097484 ! dendrite extension relationship: negatively_regulates GO:0097484 ! dendrite extension created_by: pad creation_date: 2015-02-02T15:34:00Z [Term] id: GO:1903861 name: positive regulation of dendrite extension namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. synonym: "activation of dendrite extension" NARROW [GOC:TermGenie] synonym: "up regulation of dendrite extension" EXACT [GOC:TermGenie] synonym: "up-regulation of dendrite extension" EXACT [GOC:TermGenie] synonym: "upregulation of dendrite extension" EXACT [GOC:TermGenie] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1903859 ! regulation of dendrite extension intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097484 ! dendrite extension relationship: positively_regulates GO:0097484 ! dendrite extension created_by: pad creation_date: 2015-02-02T15:34:09Z [Term] id: GO:1903862 name: positive regulation of oxidative phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:10225962] synonym: "activation of oxidative phosphorylation" NARROW [GOC:TermGenie] synonym: "activation of respiratory-chain phosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of oxidative phosphorylation" EXACT [GOC:TermGenie] synonym: "up regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of oxidative phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of oxidative phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0002082 ! regulation of oxidative phosphorylation is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:1903580 ! positive regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006119 ! oxidative phosphorylation relationship: positively_regulates GO:0006119 ! oxidative phosphorylation created_by: sl creation_date: 2015-02-02T23:40:22Z [Term] id: GO:1903863 name: P granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a P granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836] synonym: "germline granule assembly" EXACT [GOC:TermGenie] synonym: "germline granule formation" EXACT [GOC:TermGenie] synonym: "P granule formation" EXACT [GOC:TermGenie] synonym: "polar granule assembly" EXACT [GOC:TermGenie] synonym: "polar granule formation" EXACT [GOC:TermGenie] is_a: GO:0030719 ! P granule organization is_a: GO:0070925 ! organelle assembly created_by: kmv creation_date: 2015-02-04T15:27:02Z [Term] id: GO:1903864 name: P granule disassembly namespace: biological_process def: "The disaggregation of a P granule into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836] synonym: "germline granule disassembly" EXACT [GOC:TermGenie] synonym: "polar granule disassembly" EXACT [GOC:TermGenie] is_a: GO:0030719 ! P granule organization is_a: GO:1903008 ! organelle disassembly created_by: kmv creation_date: 2015-02-04T15:27:12Z [Term] id: GO:1903865 name: sigma factor antagonist complex namespace: cellular_component def: "A protein complex which is capable of sigma factor antagonist activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23687042] is_a: GO:0017053 ! transcriptional repressor complex created_by: bhm creation_date: 2015-02-04T15:39:34Z [Term] id: GO:1903866 name: palisade mesophyll development namespace: biological_process def: "The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure." [GO_REF:0000080, GOC:TermGenie, PMID:24663344] synonym: "palisade parenchyma development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: tb creation_date: 2015-02-04T21:51:44Z [Term] id: GO:1903867 name: extraembryonic membrane development namespace: biological_process def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] is_a: GO:0048856 ! anatomical structure development created_by: cjm creation_date: 2015-02-05T00:42:16Z [Term] id: GO:1903868 name: regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] synonym: "regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of MetF" RELATED [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of MTHFR activity" BROAD [GOC:TermGenie] synonym: "regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: rph creation_date: 2015-02-05T13:26:14Z [Term] id: GO:1903869 name: negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] synonym: "down regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "down regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of MetF" RELATED [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "down regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "down regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "down-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of MetF" RELATED [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "down-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "downregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of MetF" RELATED [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "downregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "downregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "inhibition of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of MetF" RELATED [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie] synonym: "inhibition of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "inhibition of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "negative regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of MetF" RELATED [GOC:TermGenie] synonym: "negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "negative regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "negative regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: negatively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: rph creation_date: 2015-02-05T13:26:25Z [Term] id: GO:1903870 name: positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] synonym: "activation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "activation of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie] synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie] synonym: "activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie] synonym: "activation of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of MetF" RELATED [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie] synonym: "activation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "activation of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "positive regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of MetF" RELATED [GOC:TermGenie] synonym: "positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "positive regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "up regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of MetF" RELATED [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "up regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "up regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "up-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of MetF" RELATED [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "up-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 1.7.99.5" RELATED [GOC:TermGenie] synonym: "upregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of MetF" RELATED [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] synonym: "upregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] synonym: "upregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: positively_regulates GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: rph creation_date: 2015-02-05T13:26:33Z [Term] id: GO:1903871 name: DNA recombinase mediator complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex." [GO_REF:0000079, GOC:rb, GOC:TermGenie, PMID:18347097] synonym: "DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] is_a: GO:0090735 ! DNA repair complex assembly created_by: rb creation_date: 2015-02-05T23:05:10Z [Term] id: GO:1903872 name: regulation of DNA recombinase mediator complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097] synonym: "regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903871 ! DNA recombinase mediator complex assembly relationship: regulates GO:1903871 ! DNA recombinase mediator complex assembly created_by: rb creation_date: 2015-02-05T23:36:45Z [Term] id: GO:1903873 name: negative regulation of DNA recombinase mediator complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097] synonym: "down regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA recombinase mediator complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of DNA recombinase mediator complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1903872 ! regulation of DNA recombinase mediator complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly relationship: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly created_by: rb creation_date: 2015-02-05T23:36:54Z [Term] id: GO:1903875 name: corticosterone binding namespace: molecular_function def: "Interacting selectively and non-covalently with corticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0043178 ! alcohol binding is_a: GO:1990239 ! steroid hormone binding created_by: mr creation_date: 2015-02-06T16:02:35Z [Term] id: GO:1903876 name: 11-deoxycortisol binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-deoxycortisol." [GO_REF:0000067, GOC:TermGenie, PMID:10802282] is_a: GO:0043178 ! alcohol binding is_a: GO:1990239 ! steroid hormone binding created_by: mr creation_date: 2015-02-06T16:02:44Z [Term] id: GO:1903877 name: 21-deoxycortisol binding namespace: molecular_function def: "Interacting selectively and non-covalently with 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0005496 ! steroid binding created_by: mr creation_date: 2015-02-06T16:02:54Z [Term] id: GO:1903878 name: 11-deoxycorticosterone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-deoxycorticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0043178 ! alcohol binding is_a: GO:1990239 ! steroid hormone binding created_by: mr creation_date: 2015-02-06T16:03:03Z [Term] id: GO:1903879 name: 11beta-hydroxyprogesterone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11beta-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0005496 ! steroid binding created_by: mr creation_date: 2015-02-06T16:03:12Z [Term] id: GO:1903880 name: 17alpha-hydroxyprogesterone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding is_a: GO:0043178 ! alcohol binding created_by: mr creation_date: 2015-02-06T16:03:22Z [Term] id: GO:1903881 name: regulation of interleukin-17-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097400 ! interleukin-17-mediated signaling pathway relationship: regulates GO:0097400 ! interleukin-17-mediated signaling pathway created_by: krc creation_date: 2015-02-06T16:26:38Z [Term] id: GO:1903882 name: negative regulation of interleukin-17-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "down regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway relationship: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway created_by: krc creation_date: 2015-02-06T16:26:47Z [Term] id: GO:1903883 name: positive regulation of interleukin-17-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "activation of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway relationship: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway created_by: krc creation_date: 2015-02-06T16:26:56Z [Term] id: GO:1903884 name: regulation of chemokine (C-C motif) ligand 20 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "regulation of CCL20 production" EXACT [GOC:TermGenie] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production relationship: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production created_by: krc creation_date: 2015-02-06T16:31:02Z [Term] id: GO:1903885 name: negative regulation of chemokine (C-C motif) ligand 20 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "down regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "down regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "down regulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "down regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] synonym: "down-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "down-regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "down-regulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "down-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] synonym: "downregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "downregulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "downregulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "downregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] synonym: "inhibition of C-C motif chemokine 20 production" NARROW [GOC:TermGenie] synonym: "inhibition of CCL-20 production" NARROW [GOC:TermGenie] synonym: "inhibition of CCL20 production" NARROW [GOC:TermGenie] synonym: "inhibition of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie] synonym: "negative regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "negative regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "negative regulation of CCL20 production" EXACT [GOC:TermGenie] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production relationship: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production created_by: krc creation_date: 2015-02-06T16:31:11Z [Term] id: GO:1903886 name: positive regulation of chemokine (C-C motif) ligand 20 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] synonym: "activation of C-C motif chemokine 20 production" NARROW [GOC:TermGenie] synonym: "activation of CCL-20 production" NARROW [GOC:TermGenie] synonym: "activation of CCL20 production" NARROW [GOC:TermGenie] synonym: "activation of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie] synonym: "positive regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "positive regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "positive regulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "up regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "up regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "up regulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "up regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] synonym: "up-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "up-regulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "up-regulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "up-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] synonym: "upregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] synonym: "upregulation of CCL-20 production" EXACT [GOC:TermGenie] synonym: "upregulation of CCL20 production" EXACT [GOC:TermGenie] synonym: "upregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production relationship: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production created_by: krc creation_date: 2015-02-06T16:31:20Z [Term] id: GO:1903888 name: regulation of plant epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090627 ! plant epidermal cell differentiation relationship: regulates GO:0090627 ! plant epidermal cell differentiation created_by: tb creation_date: 2015-02-06T22:29:38Z [Term] id: GO:1903889 name: negative regulation of plant epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] synonym: "down regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of plant epidermal cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903888 ! regulation of plant epidermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090627 ! plant epidermal cell differentiation relationship: negatively_regulates GO:0090627 ! plant epidermal cell differentiation created_by: tb creation_date: 2015-02-06T22:29:52Z [Term] id: GO:1903890 name: positive regulation of plant epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] synonym: "activation of plant epidermal cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903888 ! regulation of plant epidermal cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090627 ! plant epidermal cell differentiation relationship: positively_regulates GO:0090627 ! plant epidermal cell differentiation created_by: tb creation_date: 2015-02-06T22:30:02Z [Term] id: GO:1903891 name: regulation of ATF6-mediated unfolded protein response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "regulation of ATF6 signal transduction pathway" BROAD [GOC:TermGenie] synonym: "regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036500 ! ATF6-mediated unfolded protein response relationship: regulates GO:0036500 ! ATF6-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:17:15Z [Term] id: GO:1903892 name: negative regulation of ATF6-mediated unfolded protein response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "down regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "down regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "down regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "down regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "down regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "down-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "down-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "down-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "down-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "downregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "downregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "downregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "downregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "downregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "downregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "inhibition of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of ATF6 branch of UPR" NARROW [GOC:TermGenie] synonym: "inhibition of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "inhibition of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "inhibition of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "inhibition of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie] synonym: "inhibition of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie] synonym: "negative regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "negative regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "negative regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "negative regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "negative regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response relationship: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:17:26Z [Term] id: GO:1903893 name: positive regulation of ATF6-mediated unfolded protein response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "activation of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of ATF6 branch of UPR" NARROW [GOC:TermGenie] synonym: "activation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "activation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "activation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "activation of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie] synonym: "activation of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie] synonym: "positive regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "positive regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "positive regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "positive regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "positive regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "up regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "up regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "up regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "up regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "up regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "up-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "up-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "up-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "up-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] synonym: "upregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] synonym: "upregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "upregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] synonym: "upregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] synonym: "upregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] synonym: "upregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response relationship: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:17:36Z [Term] id: GO:1903894 name: regulation of IRE1-mediated unfolded protein response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] synonym: "regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "regulation of IRE1 signal transduction pathway" BROAD [GOC:TermGenie] synonym: "regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036498 ! IRE1-mediated unfolded protein response relationship: regulates GO:0036498 ! IRE1-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:17:46Z [Term] id: GO:1903895 name: negative regulation of IRE1-mediated unfolded protein response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "down regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "down regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "down regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "down regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "down-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "down-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "down-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "down-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "downregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "downregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "downregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "downregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "downregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie] synonym: "inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "inhibition of IRE1 branch of UPR" NARROW [GOC:TermGenie] synonym: "inhibition of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "inhibition of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] synonym: "negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "negative regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "negative regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "negative regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "negative regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "negative regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response relationship: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:17:55Z [Term] id: GO:1903896 name: positive regulation of IRE1-mediated unfolded protein response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "activation of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie] synonym: "activation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "activation of IRE1 branch of UPR" NARROW [GOC:TermGenie] synonym: "activation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "activation of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] synonym: "positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "positive regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "positive regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "positive regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "positive regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "positive regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "up regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "up regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "up regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "up regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "up-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "up-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "up-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "up-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] synonym: "upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] synonym: "upregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] synonym: "upregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "upregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] synonym: "upregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] synonym: "upregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response relationship: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:18:04Z [Term] id: GO:1903897 name: regulation of PERK-mediated unfolded protein response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "regulation of PERK signal transduction pathway" BROAD [GOC:TermGenie] synonym: "regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036499 ! PERK-mediated unfolded protein response relationship: regulates GO:0036499 ! PERK-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:18:14Z [Term] id: GO:1903898 name: negative regulation of PERK-mediated unfolded protein response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "down regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "down regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "down regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "down-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "down-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "downregulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "downregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "downregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie] synonym: "inhibition of PERK branch of UPR" NARROW [GOC:TermGenie] synonym: "inhibition of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "inhibition of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie] synonym: "negative regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "negative regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "negative regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response relationship: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:18:23Z [Term] id: GO:1903899 name: positive regulation of PERK-mediated unfolded protein response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] synonym: "activation of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie] synonym: "activation of PERK branch of UPR" NARROW [GOC:TermGenie] synonym: "activation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "activation of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie] synonym: "activation of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie] synonym: "positive regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "positive regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "positive regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "positive regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "positive regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "up regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "up regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "up-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "up-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] synonym: "upregulation of PERK branch of UPR" EXACT [GOC:TermGenie] synonym: "upregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] synonym: "upregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response relationship: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response created_by: bf creation_date: 2015-02-09T10:18:32Z [Term] id: GO:1903900 name: regulation of viral life cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] synonym: "regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "regulation of viral replication" RELATED [GOC:TermGenie] is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019058 ! viral life cycle relationship: regulates GO:0019058 ! viral life cycle created_by: pga creation_date: 2015-02-09T10:22:07Z [Term] id: GO:1903901 name: negative regulation of viral life cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] synonym: "down regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "down regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "down regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "down regulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "down regulation of viral replication" RELATED [GOC:TermGenie] synonym: "down-regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "down-regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of viral replication" RELATED [GOC:TermGenie] synonym: "downregulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "downregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "downregulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "downregulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "downregulation of viral replication" RELATED [GOC:TermGenie] synonym: "inhibition of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "inhibition of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "inhibition of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "inhibition of viral life cycle" NARROW [GOC:TermGenie] synonym: "inhibition of viral replication" RELATED [GOC:TermGenie] synonym: "negative regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "negative regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of viral replication" RELATED [GOC:TermGenie] is_a: GO:0048525 ! negative regulation of viral process is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019058 ! viral life cycle relationship: negatively_regulates GO:0019058 ! viral life cycle created_by: pga creation_date: 2015-02-09T10:22:16Z [Term] id: GO:1903902 name: positive regulation of viral life cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] synonym: "activation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "activation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "activation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "activation of viral life cycle" NARROW [GOC:TermGenie] synonym: "activation of viral replication" RELATED [GOC:TermGenie] synonym: "positive regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "positive regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "positive regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "positive regulation of viral replication" RELATED [GOC:TermGenie] synonym: "up regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "up regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "up regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "up regulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "up regulation of viral replication" RELATED [GOC:TermGenie] synonym: "up-regulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "up-regulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "up-regulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of viral replication" RELATED [GOC:TermGenie] synonym: "upregulation of lytic viral life cycle" RELATED [GOC:TermGenie] synonym: "upregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] synonym: "upregulation of viral infectious cycle" RELATED [GOC:TermGenie] synonym: "upregulation of viral life cycle" EXACT [GOC:TermGenie] synonym: "upregulation of viral replication" RELATED [GOC:TermGenie] is_a: GO:0048524 ! positive regulation of viral process is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019058 ! viral life cycle relationship: positively_regulates GO:0019058 ! viral life cycle created_by: pga creation_date: 2015-02-09T10:22:25Z [Term] id: GO:1903903 name: regulation of establishment of T cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:2000114 ! regulation of establishment of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001768 ! establishment of T cell polarity relationship: regulates GO:0001768 ! establishment of T cell polarity created_by: als creation_date: 2015-02-09T10:50:21Z [Term] id: GO:1903904 name: negative regulation of establishment of T cell polarity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050868 ! negative regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001768 ! establishment of T cell polarity relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity created_by: als creation_date: 2015-02-09T10:50:30Z [Term] id: GO:1903905 name: positive regulation of establishment of T cell polarity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of T cell polarization" NARROW [GOC:TermGenie] synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001768 ! establishment of T cell polarity relationship: positively_regulates GO:0001768 ! establishment of T cell polarity created_by: als creation_date: 2015-02-09T10:50:40Z [Term] id: GO:1903906 name: regulation of plasma membrane raft polarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044858 ! plasma membrane raft polarization relationship: regulates GO:0044858 ! plasma membrane raft polarization created_by: als creation_date: 2015-02-09T10:53:56Z [Term] id: GO:1903907 name: negative regulation of plasma membrane raft polarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] synonym: "downregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] synonym: "inhibition of plasma membrane raft polarization" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903906 ! regulation of plasma membrane raft polarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044858 ! plasma membrane raft polarization relationship: negatively_regulates GO:0044858 ! plasma membrane raft polarization created_by: als creation_date: 2015-02-09T10:54:05Z [Term] id: GO:1903908 name: positive regulation of plasma membrane raft polarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of plasma membrane raft polarization" NARROW [GOC:TermGenie] synonym: "up regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] synonym: "upregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903906 ! regulation of plasma membrane raft polarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044858 ! plasma membrane raft polarization relationship: positively_regulates GO:0044858 ! plasma membrane raft polarization created_by: als creation_date: 2015-02-09T10:54:15Z [Term] id: GO:1903909 name: regulation of receptor clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043113 ! receptor clustering relationship: regulates GO:0043113 ! receptor clustering created_by: als creation_date: 2015-02-09T10:56:33Z [Term] id: GO:1903910 name: negative regulation of receptor clustering namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of receptor clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor clustering" EXACT [GOC:TermGenie] synonym: "downregulation of receptor clustering" EXACT [GOC:TermGenie] synonym: "inhibition of receptor clustering" NARROW [GOC:TermGenie] is_a: GO:1903909 ! regulation of receptor clustering is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043113 ! receptor clustering relationship: negatively_regulates GO:0043113 ! receptor clustering created_by: als creation_date: 2015-02-09T10:56:42Z [Term] id: GO:1903911 name: positive regulation of receptor clustering namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of receptor clustering" NARROW [GOC:TermGenie] synonym: "up regulation of receptor clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor clustering" EXACT [GOC:TermGenie] synonym: "upregulation of receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1903909 ! regulation of receptor clustering is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043113 ! receptor clustering relationship: positively_regulates GO:0043113 ! receptor clustering created_by: als creation_date: 2015-02-09T10:56:51Z [Term] id: GO:1903912 name: negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242] synonym: "down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "down-regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "downregulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "inhibition of eiF2alpha phosphorylation in response to ER stress" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [] synonym: "negative regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "negative regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf] synonym: "negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress relationship: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress created_by: bf creation_date: 2015-02-09T10:58:55Z [Term] id: GO:1903913 name: regulation of fusion of virus membrane with host plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of viral envelope fusion" BROAD [GOC:TermGenie] synonym: "regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] is_a: GO:0046596 ! regulation of viral entry into host cell is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane relationship: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane created_by: als creation_date: 2015-02-09T11:13:19Z [Term] id: GO:1903914 name: negative regulation of fusion of virus membrane with host plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "down regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "down regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "down regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "down-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "downregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "downregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "downregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "downregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "inhibition of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "inhibition of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie] synonym: "inhibition of viral envelope fusion with host membrane" NARROW [GOC:TermGenie] synonym: "inhibition of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of viral penetration via membrane fusion" NARROW [GOC:TermGenie] synonym: "inhibition of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "negative regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "negative regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] is_a: GO:0046597 ! negative regulation of viral entry into host cell is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane relationship: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane created_by: als creation_date: 2015-02-09T11:13:32Z [Term] id: GO:1903915 name: positive regulation of fusion of virus membrane with host plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "activation of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie] synonym: "activation of viral envelope fusion with host membrane" NARROW [GOC:TermGenie] synonym: "activation of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of viral penetration via membrane fusion" NARROW [GOC:TermGenie] synonym: "activation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "positive regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "positive regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "positive regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "up regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "up regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "up regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "up regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "up-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] synonym: "upregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] synonym: "upregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] synonym: "upregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] synonym: "upregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] is_a: GO:0046598 ! positive regulation of viral entry into host cell is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane relationship: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane created_by: als creation_date: 2015-02-09T11:13:41Z [Term] id: GO:1903916 name: regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [] synonym: "regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf] synonym: "regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0032535 ! regulation of cellular component size is_a: GO:0035304 ! regulation of protein dephosphorylation is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress relationship: regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress created_by: bf creation_date: 2015-02-09T11:18:14Z [Term] id: GO:1903917 name: positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] synonym: "activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "activation of eIF2alpha dephosphorylation in response to ER stress" NARROW [GOC:TermGenie] synonym: "activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" RELATED [] synonym: "positive regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "positive regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf] synonym: "positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] is_a: GO:0035307 ! positive regulation of protein dephosphorylation is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903916 ! regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress relationship: positively_regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress created_by: bf creation_date: 2015-02-09T11:18:24Z [Term] id: GO:1903918 name: regulation of actin filament severing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "regulation of F-actin severing" EXACT [GOC:TermGenie] is_a: GO:0032970 ! regulation of actin filament-based process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051014 ! actin filament severing relationship: regulates GO:0051014 ! actin filament severing created_by: als creation_date: 2015-02-10T11:01:21Z [Term] id: GO:1903919 name: negative regulation of actin filament severing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "down regulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "down regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "down regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "down regulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "down-regulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "down-regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "down-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "down-regulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "downregulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "downregulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "downregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "downregulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "inhibition of actin filament severing" NARROW [GOC:TermGenie] synonym: "inhibition of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "inhibition of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "inhibition of F-actin severing" NARROW [GOC:TermGenie] synonym: "negative regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "negative regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "negative regulation of F-actin severing" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903918 ! regulation of actin filament severing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051014 ! actin filament severing relationship: negatively_regulates GO:0051014 ! actin filament severing created_by: als creation_date: 2015-02-10T11:01:31Z [Term] id: GO:1903920 name: positive regulation of actin filament severing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "activation of actin filament severing" NARROW [GOC:TermGenie] synonym: "activation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "activation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "activation of F-actin severing" NARROW [GOC:TermGenie] synonym: "positive regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "positive regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "positive regulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "up regulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "up regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "up regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "up regulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "up-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "up-regulation of F-actin severing" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament severing" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament severing activity" RELATED [GOC:TermGenie] synonym: "upregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] synonym: "upregulation of F-actin severing" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903918 ! regulation of actin filament severing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051014 ! actin filament severing relationship: positively_regulates GO:0051014 ! actin filament severing created_by: als creation_date: 2015-02-10T11:01:40Z [Term] id: GO:1903921 name: regulation of protein processing in phagocytic vesicle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "regulation of protein processing in phagosome" EXACT [GOC:TermGenie] is_a: GO:0070613 ! regulation of protein processing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900756 ! protein processing in phagocytic vesicle relationship: regulates GO:1900756 ! protein processing in phagocytic vesicle created_by: als creation_date: 2015-02-10T11:16:54Z [Term] id: GO:1903922 name: negative regulation of protein processing in phagocytic vesicle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "down regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "down regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "down regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "down-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "down-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "downregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "downregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "inhibition of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "inhibition of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "inhibition of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein processing in phagosome" NARROW [GOC:TermGenie] synonym: "negative regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "negative regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "negative regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "negative regulation of protein processing in phagosome" EXACT [GOC:TermGenie] is_a: GO:0010955 ! negative regulation of protein processing is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle relationship: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle created_by: als creation_date: 2015-02-10T11:17:05Z [Term] id: GO:1903923 name: positive regulation of protein processing in phagocytic vesicle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] synonym: "activation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "activation of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie] synonym: "activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie] synonym: "activation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "activation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "activation of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein processing in phagosome" NARROW [GOC:TermGenie] synonym: "positive regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "positive regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "positive regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "positive regulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "up regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "up regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "up regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "up-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "up-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein processing in phagosome" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] synonym: "upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] synonym: "upregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] synonym: "upregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein processing in phagosome" EXACT [GOC:TermGenie] is_a: GO:0010954 ! positive regulation of protein processing is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle relationship: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle created_by: als creation_date: 2015-02-10T11:17:14Z [Term] id: GO:1903924 name: estradiol binding namespace: molecular_function def: "Interacting selectively and non-covalently with estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584] is_a: GO:0005496 ! steroid binding is_a: GO:0099130 ! estrogen binding created_by: sl creation_date: 2015-02-11T00:11:34Z [Term] id: GO:1903925 name: response to bisphenol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-02-11T00:16:46Z [Term] id: GO:1903926 name: cellular response to bisphenol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903925 ! response to bisphenol A created_by: sl creation_date: 2015-02-11T00:17:04Z [Term] id: GO:1903927 name: response to cyanide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009636 ! response to toxic substance is_a: GO:0010033 ! response to organic substance created_by: sl creation_date: 2015-02-11T19:04:19Z [Term] id: GO:1903928 name: cellular response to cyanide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1903927 ! response to cyanide created_by: sl creation_date: 2015-02-11T19:04:28Z [Term] id: GO:1903929 name: primary palate development namespace: biological_process def: "The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mgi_curators, GOC:TermGenie, PMID:24644145, PMID:25504820] synonym: "palatum primarium development" RELATED [GOC:TermGenie] synonym: "primary palate process development" EXACT [GOC:TermGenie] synonym: "primitive palate development" RELATED [GOC:TermGenie] synonym: "processus palatinus medianus development" RELATED [GOC:TermGenie] is_a: GO:0060021 ! roof of mouth development created_by: cynthia.smith creation_date: 2015-02-11T22:42:38Z [Term] id: GO:1903930 name: regulation of pyrimidine-containing compound salvage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302] synonym: "regulation of pyrimidine salvage" RELATED [GOC:TermGenie] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008655 ! pyrimidine-containing compound salvage relationship: regulates GO:0008655 ! pyrimidine-containing compound salvage created_by: al creation_date: 2015-02-12T14:09:05Z [Term] id: GO:1903931 name: positive regulation of pyrimidine-containing compound salvage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302] synonym: "activation of pyrimidine salvage" RELATED [GOC:TermGenie] synonym: "activation of pyrimidine-containing compound salvage" NARROW [GOC:TermGenie] synonym: "positive regulation of pyrimidine salvage" RELATED [GOC:TermGenie] synonym: "up regulation of pyrimidine salvage" RELATED [GOC:TermGenie] synonym: "up regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine salvage" RELATED [GOC:TermGenie] synonym: "up-regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine salvage" RELATED [GOC:TermGenie] synonym: "upregulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:1903930 ! regulation of pyrimidine-containing compound salvage intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage relationship: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage created_by: al creation_date: 2015-02-12T14:09:15Z [Term] id: GO:1903932 name: regulation of DNA primase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0051338 ! regulation of transferase activity is_a: GO:0090329 ! regulation of DNA-dependent DNA replication is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003896 ! DNA primase activity relationship: regulates GO:0003896 ! DNA primase activity created_by: mah creation_date: 2015-02-12T14:28:26Z [Term] id: GO:1903933 name: negative regulation of DNA primase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] synonym: "down regulation of DNA primase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA primase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA primase activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA primase activity" NARROW [GOC:TermGenie] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1902679 ! negative regulation of RNA biosynthetic process is_a: GO:1903932 ! regulation of DNA primase activity is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003896 ! DNA primase activity relationship: negatively_regulates GO:0003896 ! DNA primase activity created_by: mah creation_date: 2015-02-12T14:28:36Z [Term] id: GO:1903934 name: positive regulation of DNA primase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] synonym: "activation of DNA primase activity" NARROW [GOC:TermGenie] synonym: "up regulation of DNA primase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA primase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA primase activity" EXACT [GOC:TermGenie] is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1902680 ! positive regulation of RNA biosynthetic process is_a: GO:1903932 ! regulation of DNA primase activity is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003896 ! DNA primase activity relationship: positively_regulates GO:0003896 ! DNA primase activity created_by: mah creation_date: 2015-02-12T14:28:45Z [Term] id: GO:1903935 name: response to sodium arsenite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] is_a: GO:0009635 ! response to herbicide is_a: GO:0010035 ! response to inorganic substance is_a: GO:0017085 ! response to insecticide is_a: GO:0046677 ! response to antibiotic is_a: GO:0046685 ! response to arsenic-containing substance is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1902074 ! response to salt created_by: sl creation_date: 2015-02-12T20:54:33Z [Term] id: GO:1903936 name: cellular response to sodium arsenite namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071243 ! cellular response to arsenic-containing substance is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1902075 ! cellular response to salt is_a: GO:1903935 ! response to sodium arsenite created_by: sl creation_date: 2015-02-12T20:54:53Z [Term] id: GO:1903937 name: response to acrylamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-02-12T22:00:24Z [Term] id: GO:1903938 name: cellular response to acrylamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903937 ! response to acrylamide created_by: sl creation_date: 2015-02-12T22:00:34Z [Term] id: GO:1903939 name: regulation of TORC2 signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430] synonym: "regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] is_a: GO:0032006 ! regulation of TOR signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038203 ! TORC2 signaling relationship: regulates GO:0038203 ! TORC2 signaling created_by: al creation_date: 2015-02-16T18:28:39Z [Term] id: GO:1903940 name: negative regulation of TORC2 signaling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430] synonym: "down regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of TORC2 signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of TORC2 signaling" EXACT [GOC:TermGenie] synonym: "downregulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of TORC2 signaling" EXACT [GOC:TermGenie] synonym: "inhibition of TORC2 signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of TORC2 signaling" NARROW [GOC:TermGenie] synonym: "negative regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] is_a: GO:0032007 ! negative regulation of TOR signaling is_a: GO:1903939 ! regulation of TORC2 signaling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038203 ! TORC2 signaling relationship: negatively_regulates GO:0038203 ! TORC2 signaling created_by: al creation_date: 2015-02-16T18:28:50Z [Term] id: GO:1903941 name: negative regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system created_by: sl creation_date: 2015-02-17T20:26:24Z [Term] id: GO:1903942 name: positive regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie] synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system created_by: sl creation_date: 2015-02-17T20:26:35Z [Term] id: GO:1903943 name: regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097284 ! hepatocyte apoptotic process relationship: regulates GO:0097284 ! hepatocyte apoptotic process created_by: sl creation_date: 2015-02-19T12:54:40Z [Term] id: GO:1903944 name: negative regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097284 ! hepatocyte apoptotic process relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process created_by: sl creation_date: 2015-02-19T12:54:50Z [Term] id: GO:1903945 name: positive regulation of hepatocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1903943 ! regulation of hepatocyte apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097284 ! hepatocyte apoptotic process relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process created_by: sl creation_date: 2015-02-19T12:54:59Z [Term] id: GO:1903946 name: negative regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential relationship: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential created_by: nc creation_date: 2015-02-20T14:31:55Z [Term] id: GO:1903947 name: positive regulation of ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential is_a: GO:0106134 ! positive regulation of cardiac muscle cell contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential relationship: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential created_by: nc creation_date: 2015-02-20T14:32:04Z [Term] id: GO:1903948 name: negative regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction is_a: GO:1903780 ! negative regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential relationship: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential created_by: nc creation_date: 2015-02-20T14:36:33Z [Term] id: GO:1903949 name: positive regulation of atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential is_a: GO:0106134 ! positive regulation of cardiac muscle cell contraction is_a: GO:1903781 ! positive regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential relationship: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential created_by: nc creation_date: 2015-02-20T14:36:42Z [Term] id: GO:1903950 name: negative regulation of AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential is_a: GO:1903780 ! negative regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086016 ! AV node cell action potential relationship: negatively_regulates GO:0086016 ! AV node cell action potential created_by: nc creation_date: 2015-02-20T14:59:41Z [Term] id: GO:1903951 name: positive regulation of AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential is_a: GO:1903781 ! positive regulation of cardiac conduction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086016 ! AV node cell action potential relationship: positively_regulates GO:0086016 ! AV node cell action potential created_by: nc creation_date: 2015-02-20T14:59:50Z [Term] id: GO:1903952 name: regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization relationship: regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization created_by: nc creation_date: 2015-02-24T10:32:06Z [Term] id: GO:1903953 name: negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity is_a: GO:1903948 ! negative regulation of atrial cardiac muscle cell action potential is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization relationship: negatively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization created_by: nc creation_date: 2015-02-24T10:32:16Z [Term] id: GO:1903954 name: positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity is_a: GO:1903949 ! positive regulation of atrial cardiac muscle cell action potential is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization relationship: positively_regulates GO:0086089 ! voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization created_by: nc creation_date: 2015-02-24T10:32:24Z [Term] id: GO:1903955 name: positive regulation of protein targeting to mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810] comment: An example of this is PINK1 in human (UniProt symbol Q9BXM7) in PMID:24270810 inferred from mutant phenotype. synonym: "activation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "activation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "activation of protein import into mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to mitochondria" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of protein-mitochondrial targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "positive regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "positive regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "positive regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "up regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "up regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "up-regulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial protein import" RELATED [GOC:TermGenie] synonym: "upregulation of mitochondrial translocation" RELATED [GOC:TermGenie] synonym: "upregulation of protein import into mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1903214 ! regulation of protein targeting to mitochondrion is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006626 ! protein targeting to mitochondrion relationship: positively_regulates GO:0006626 ! protein targeting to mitochondrion created_by: pad creation_date: 2015-02-24T16:58:21Z [Term] id: GO:1903956 name: response to latrunculin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025] is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol created_by: al creation_date: 2015-02-24T17:00:11Z [Term] id: GO:1903957 name: cellular response to latrunculin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1903956 ! response to latrunculin B created_by: al creation_date: 2015-02-24T17:00:21Z [Term] id: GO:1903958 name: nitric-oxide synthase complex namespace: cellular_component def: "A protein complex which is capable of nitric-oxide synthase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:25417112] comment: An example of this is NOS2 in human (P35228) in PMID:25417112 (inferred from direct assay). synonym: "iNOS-S100A8/A9 complex" NARROW [] is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2015-02-25T10:45:01Z [Term] id: GO:1903959 name: regulation of anion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0034765 ! regulation of ion transmembrane transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098656 ! anion transmembrane transport relationship: regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:25Z [Term] id: GO:1903960 name: negative regulation of anion transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098656 ! anion transmembrane transport relationship: negatively_regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:35Z [Term] id: GO:1903961 name: positive regulation of anion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:1903959 ! regulation of anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098656 ! anion transmembrane transport relationship: positively_regulates GO:0098656 ! anion transmembrane transport created_by: pr creation_date: 2015-02-25T13:52:44Z [Term] id: GO:1903962 name: arachidonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arachidonate from one side of a membrane to the other." [GO_REF:0000066, GOC:bhm, GOC:TermGenie, PMID:15642721] comment: An example of this is S100A9 in human (P06702) in PMID:15642721 (inferred from direct assay). synonym: "arachidonate transporter activity" RELATED [] synonym: "arachidonic acid transporter activity" RELATED [] is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0071714 ! icosanoid transmembrane transporter activity relationship: part_of GO:1903963 ! arachidonate transport created_by: bhm creation_date: 2015-02-25T15:51:12Z [Term] id: GO:1903963 name: arachidonate transport namespace: biological_process def: "The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:bhm, GOC:TermGenie, PMID:15642721] synonym: "arachidonic acid transport" EXACT [] is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0071715 ! icosanoid transport created_by: bhm creation_date: 2015-02-25T16:06:14Z [Term] id: GO:1903964 name: monounsaturated fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. synonym: "monounsaturated fatty acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0033559 ! unsaturated fatty acid metabolic process created_by: pr creation_date: 2015-02-25T20:35:48Z [Term] id: GO:1903965 name: monounsaturated fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] synonym: "monounsaturated fatty acid breakdown" EXACT [GOC:TermGenie] synonym: "monounsaturated fatty acid catabolism" EXACT [GOC:TermGenie] synonym: "monounsaturated fatty acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:1903964 ! monounsaturated fatty acid metabolic process created_by: pr creation_date: 2015-02-25T20:35:58Z [Term] id: GO:1903966 name: monounsaturated fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. synonym: "monounsaturated fatty acid anabolism" EXACT [GOC:TermGenie] synonym: "monounsaturated fatty acid biosynthesis" EXACT [GOC:TermGenie] synonym: "monounsaturated fatty acid formation" EXACT [GOC:TermGenie] synonym: "monounsaturated fatty acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:1903964 ! monounsaturated fatty acid metabolic process created_by: pr creation_date: 2015-02-25T20:36:07Z [Term] id: GO:1903967 name: response to micafungin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] is_a: GO:0033993 ! response to lipid is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: al creation_date: 2015-02-27T09:57:38Z [Term] id: GO:1903968 name: cellular response to micafungin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901653 ! cellular response to peptide is_a: GO:1903967 ! response to micafungin created_by: al creation_date: 2015-02-27T09:57:44Z [Term] id: GO:1903969 name: regulation of response to macrophage colony-stimulating factor namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036005 ! response to macrophage colony-stimulating factor relationship: regulates GO:0036005 ! response to macrophage colony-stimulating factor created_by: nc creation_date: 2015-03-02T14:41:02Z [Term] id: GO:1903970 name: negative regulation of response to macrophage colony-stimulating factor namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "down regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "down regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "down-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "down-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "downregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "downregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of response to M-CSF" NARROW [GOC:TermGenie] synonym: "inhibition of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] synonym: "inhibition of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "negative regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "negative regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] is_a: GO:0060761 ! negative regulation of response to cytokine stimulus is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor relationship: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor created_by: nc creation_date: 2015-03-02T14:41:08Z [Term] id: GO:1903971 name: positive regulation of response to macrophage colony-stimulating factor namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of response to M-CSF" NARROW [GOC:TermGenie] synonym: "activation of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] synonym: "activation of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "positive regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "positive regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "up regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "up regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "up-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "up-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of response to M-CSF" EXACT [GOC:TermGenie] synonym: "upregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "upregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] is_a: GO:0060760 ! positive regulation of response to cytokine stimulus is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor relationship: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor created_by: nc creation_date: 2015-03-02T14:41:14Z [Term] id: GO:1903972 name: regulation of cellular response to macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus relationship: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus created_by: nc creation_date: 2015-03-02T14:50:14Z [Term] id: GO:1903973 name: negative regulation of cellular response to macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903970 ! negative regulation of response to macrophage colony-stimulating factor is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus relationship: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus created_by: nc creation_date: 2015-03-02T14:50:20Z [Term] id: GO:1903974 name: positive regulation of cellular response to macrophage colony-stimulating factor stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie] synonym: "activation of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] synonym: "activation of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903971 ! positive regulation of response to macrophage colony-stimulating factor is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus relationship: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus created_by: nc creation_date: 2015-03-02T14:50:25Z [Term] id: GO:1903975 name: regulation of glial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008347 ! glial cell migration relationship: regulates GO:0008347 ! glial cell migration created_by: nc creation_date: 2015-03-02T15:13:31Z [Term] id: GO:1903976 name: negative regulation of glial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008347 ! glial cell migration relationship: negatively_regulates GO:0008347 ! glial cell migration created_by: nc creation_date: 2015-03-02T15:13:38Z [Term] id: GO:1903977 name: positive regulation of glial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of glia cell migration" NARROW [GOC:TermGenie] synonym: "activation of glial cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008347 ! glial cell migration relationship: positively_regulates GO:0008347 ! glial cell migration created_by: nc creation_date: 2015-03-02T15:13:43Z [Term] id: GO:1903978 name: regulation of microglial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0043030 ! regulation of macrophage activation is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001774 ! microglial cell activation relationship: regulates GO:0001774 ! microglial cell activation created_by: nc creation_date: 2015-03-02T15:17:33Z [Term] id: GO:1903979 name: negative regulation of microglial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie] is_a: GO:0043031 ! negative regulation of macrophage activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001774 ! microglial cell activation relationship: negatively_regulates GO:0001774 ! microglial cell activation created_by: nc creation_date: 2015-03-02T15:17:39Z [Term] id: GO:1903980 name: positive regulation of microglial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie] is_a: GO:0043032 ! positive regulation of macrophage activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001774 ! microglial cell activation relationship: positively_regulates GO:0001774 ! microglial cell activation created_by: nc creation_date: 2015-03-02T15:17:44Z [Term] id: GO:1903981 name: enterobactin binding namespace: molecular_function def: "Interacting selectively and non-covalently with enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132] synonym: "enterochelin binding" EXACT [] synonym: "siderophore binding" BROAD [] is_a: GO:0043168 ! anion binding is_a: GO:0048037 ! cofactor binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: mr creation_date: 2015-03-02T17:21:54Z [Term] id: GO:1903982 name: negative regulation of microvillus length namespace: biological_process def: "A process that decreases the length of a microvillus." [GOC:als, PMID:22114352] synonym: "down regulation of regulation of microvillus length" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of microvillus length" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of microvillus length" EXACT [GOC:TermGenie] synonym: "inhibition of regulation of microvillus length" NARROW [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0032532 ! regulation of microvillus length created_by: als creation_date: 2015-03-03T13:23:52Z [Term] id: GO:1903983 name: positive regulation of microvillus length namespace: biological_process def: "A process that increases the length of a microvillus." [GOC:als, PMID:22114352] synonym: "activation of regulation of microvillus length" NARROW [GOC:TermGenie] synonym: "up regulation of regulation of microvillus length" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of microvillus length" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of microvillus length" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0032532 ! regulation of microvillus length created_by: als creation_date: 2015-03-03T13:23:58Z [Term] id: GO:1903984 name: positive regulation of TRAIL-activated apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851] synonym: "activation of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway relationship: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway created_by: bf creation_date: 2015-03-03T15:04:21Z [Term] id: GO:1903985 name: regulation of intestinal D-glucose absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption." [GO_REF:0000058, GOA:als, GOC:TermGenie, PMID:22114352] is_a: GO:1904478 ! regulation of intestinal absorption intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001951 ! intestinal D-glucose absorption relationship: regulates GO:0001951 ! intestinal D-glucose absorption created_by: als creation_date: 2015-03-04T10:07:55Z [Term] id: GO:1903988 name: iron ion export across plasma membrane namespace: biological_process alt_id: GO:1903414 def: "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116] comment: An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9). synonym: "ferrous iron export" NARROW [] synonym: "ferrous iron export across plasma membrane" NARROW [] synonym: "iron cation export" RELATED [] synonym: "iron(2+) export" RELATED [] is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane created_by: rl creation_date: 2014-09-03T13:01:37Z [Term] id: GO:1903992 name: obsolete regulation of protein stabilization namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] comment: This term was made obsolete because it was created in error. synonym: "regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "regulation of protein stabilization" EXACT [] synonym: "regulation of protein stabilization activity" RELATED [GOC:TermGenie] is_obsolete: true consider: GO:0031647 created_by: pga creation_date: 2015-03-05T13:32:49Z [Term] id: GO:1903993 name: obsolete negative regulation of protein stabilization namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] comment: This term was made obsolete because it was created in error. synonym: "down regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "down regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "down regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "down regulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "down regulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "down-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "down-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "down-regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "down-regulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "downregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "downregulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "downregulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "downregulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "downregulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "inhibition of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "inhibition of positive regulation of protein stability" NARROW [GOC:TermGenie] synonym: "inhibition of protein sequestering" RELATED [GOC:TermGenie] synonym: "inhibition of protein stabilization" NARROW [GOC:TermGenie] synonym: "inhibition of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "negative regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "negative regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "negative regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "negative regulation of protein stabilization" EXACT [] synonym: "negative regulation of protein stabilization activity" RELATED [GOC:TermGenie] is_obsolete: true consider: GO:0031648 created_by: pga creation_date: 2015-03-05T13:32:55Z [Term] id: GO:1903994 name: obsolete positive regulation of protein stabilization namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] comment: This term was made obsolete because it was created in error. synonym: "activation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "activation of positive regulation of protein stability" NARROW [GOC:TermGenie] synonym: "activation of protein sequestering" RELATED [GOC:TermGenie] synonym: "activation of protein stabilization" NARROW [GOC:TermGenie] synonym: "activation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "positive regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "positive regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "positive regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "positive regulation of protein stabilization" EXACT [] synonym: "positive regulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "up regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "up regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "up regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "up regulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "up regulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "up-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "up-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "up-regulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "up-regulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein stabilization activity" RELATED [GOC:TermGenie] synonym: "upregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] synonym: "upregulation of positive regulation of protein stability" EXACT [GOC:TermGenie] synonym: "upregulation of protein sequestering" RELATED [GOC:TermGenie] synonym: "upregulation of protein stabilization" EXACT [GOC:TermGenie] synonym: "upregulation of protein stabilization activity" RELATED [GOC:TermGenie] is_obsolete: true consider: GO:0050821 created_by: pga creation_date: 2015-03-05T13:33:00Z [Term] id: GO:1903995 name: regulation of non-membrane spanning protein tyrosine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] synonym: "regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:protein-tyrosine O-phosphotransferase activity" BROAD [GOC:TermGenie] synonym: "regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity relationship: regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity created_by: nc creation_date: 2015-03-05T16:34:35Z [Term] id: GO:1903996 name: negative regulation of non-membrane spanning protein tyrosine kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] synonym: "down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "down regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "down regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "down regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "down regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "downregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "downregulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "downregulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "downregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie] synonym: "inhibition of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "inhibition of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "inhibition of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "inhibition of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity relationship: negatively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity created_by: nc creation_date: 2015-03-05T16:34:41Z [Term] id: GO:1903997 name: positive regulation of non-membrane spanning protein tyrosine kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] synonym: "activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie] synonym: "activation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "activation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "activation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "activation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "activation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "activation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "activation of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "activation of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "activation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "positive regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "positive regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "positive regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "up regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "up regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "up regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "up regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "up-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "up-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "up-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] synonym: "upregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of janus kinase 1 activity" NARROW [GOC:TermGenie] synonym: "upregulation of janus kinase 2 activity" NARROW [GOC:TermGenie] synonym: "upregulation of janus kinase 3 activity" NARROW [GOC:TermGenie] synonym: "upregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity relationship: positively_regulates GO:0004715 ! non-membrane spanning protein tyrosine kinase activity created_by: nc creation_date: 2015-03-05T16:34:46Z [Term] id: GO:1903998 name: regulation of eating behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "regulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042755 ! eating behavior relationship: regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:22Z [Term] id: GO:1903999 name: negative regulation of eating behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "down regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "down regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "down-regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "downregulation of eating behavior" EXACT [GOC:TermGenie] synonym: "downregulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "inhibition of eating behavior" NARROW [GOC:TermGenie] synonym: "inhibition of eating behaviour" NARROW [GOC:TermGenie] synonym: "negative regulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:1903998 ! regulation of eating behavior is_a: GO:2000252 ! negative regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042755 ! eating behavior relationship: negatively_regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:28Z [Term] id: GO:1904000 name: positive regulation of eating behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] synonym: "activation of eating behavior" NARROW [GOC:TermGenie] synonym: "activation of eating behaviour" NARROW [GOC:TermGenie] synonym: "positive regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "up regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "up regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "up-regulation of eating behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of eating behaviour" EXACT [GOC:TermGenie] synonym: "upregulation of eating behavior" EXACT [GOC:TermGenie] synonym: "upregulation of eating behaviour" EXACT [GOC:TermGenie] is_a: GO:1903998 ! regulation of eating behavior is_a: GO:2000253 ! positive regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042755 ! eating behavior relationship: positively_regulates GO:0042755 ! eating behavior created_by: sl creation_date: 2015-03-05T20:40:35Z [Term] id: GO:1904001 name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [GO_REF:0000063, GOC:al, GOC:TermGenie, PMID:23695302] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "activation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "activation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "up-regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "upregulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: pr creation_date: 2015-03-05T21:25:42Z [Term] id: GO:1904002 name: regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "regulation of sebocyte proliferation" RELATED [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990654 ! sebum secreting cell proliferation relationship: regulates GO:1990654 ! sebum secreting cell proliferation created_by: hjd creation_date: 2015-03-06T16:19:44Z [Term] id: GO:1904003 name: negative regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "down regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "down regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of sebum secreting cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of sebocyte proliferation" RELATED [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1904002 ! regulation of sebum secreting cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990654 ! sebum secreting cell proliferation relationship: negatively_regulates GO:1990654 ! sebum secreting cell proliferation created_by: hjd creation_date: 2015-03-06T16:19:50Z [Term] id: GO:1904004 name: positive regulation of sebum secreting cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] synonym: "activation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "activation of sebum secreting cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of sebocyte proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1904002 ! regulation of sebum secreting cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990654 ! sebum secreting cell proliferation relationship: positively_regulates GO:1990654 ! sebum secreting cell proliferation created_by: hjd creation_date: 2015-03-06T16:19:56Z [Term] id: GO:1904005 name: regulation of phospholipase D activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] synonym: "regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0010517 ! regulation of phospholipase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004630 ! phospholipase D activity relationship: regulates GO:0004630 ! phospholipase D activity created_by: sl creation_date: 2015-03-06T17:20:05Z [Term] id: GO:1904006 name: negative regulation of phospholipase D activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] synonym: "down regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "down regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phospholipase D activity" EXACT [GOC:TermGenie] synonym: "down-regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "down-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phospholipase D activity" EXACT [GOC:TermGenie] synonym: "downregulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "downregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phospholipase D activity" EXACT [GOC:TermGenie] synonym: "inhibition of choline phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of lecithinase D activity" NARROW [GOC:TermGenie] synonym: "inhibition of lipophosphodiesterase II activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phospholipase D activity" NARROW [GOC:TermGenie] synonym: "negative regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "negative regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0010519 ! negative regulation of phospholipase activity is_a: GO:1904005 ! regulation of phospholipase D activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004630 ! phospholipase D activity relationship: negatively_regulates GO:0004630 ! phospholipase D activity created_by: sl creation_date: 2015-03-06T17:20:11Z [Term] id: GO:1904007 name: positive regulation of phospholipase D activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] synonym: "activation of choline phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of lecithinase D activity" NARROW [GOC:TermGenie] synonym: "activation of lipophosphodiesterase II activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of phospholipase D activity" NARROW [GOC:TermGenie] synonym: "positive regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "positive regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "up regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phospholipase D activity" EXACT [GOC:TermGenie] synonym: "up-regulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "up-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phospholipase D activity" EXACT [GOC:TermGenie] synonym: "upregulation of choline phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of lecithinase D activity" EXACT [GOC:TermGenie] synonym: "upregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phospholipase D activity" EXACT [GOC:TermGenie] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:1904005 ! regulation of phospholipase D activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004630 ! phospholipase D activity relationship: positively_regulates GO:0004630 ! phospholipase D activity created_by: sl creation_date: 2015-03-06T17:20:17Z [Term] id: GO:1904008 name: response to monosodium glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590] is_a: GO:1902074 ! response to salt created_by: sl creation_date: 2015-03-06T18:26:34Z [Term] id: GO:1904009 name: cellular response to monosodium glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590] is_a: GO:1902075 ! cellular response to salt is_a: GO:1904008 ! response to monosodium glutamate created_by: sl creation_date: 2015-03-06T18:26:40Z [Term] id: GO:1904010 name: response to Aroclor 1254 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] is_a: GO:0009636 ! response to toxic substance created_by: sl creation_date: 2015-03-06T18:35:00Z [Term] id: GO:1904011 name: cellular response to Aroclor 1254 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904010 ! response to Aroclor 1254 created_by: sl creation_date: 2015-03-06T18:35:06Z [Term] id: GO:1904012 name: obsolete platinum binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with platinum." [GO_REF:0000067, GOC:TermGenie, PMID:10089464] comment: The reason for obsoletion is that binding to platinum does not have physiological relevance. is_obsolete: true created_by: sl creation_date: 2015-03-06T19:07:37Z [Term] id: GO:1904013 name: obsolete xenon atom binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with xenon atom." [GO_REF:0000067, GOC:TermGenie, PMID:10089464] comment: The reason for obsoletion is that binding to xenon does not have physiological relevance. is_obsolete: true created_by: sl creation_date: 2015-03-06T19:07:43Z [Term] id: GO:1904014 name: response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0060359 ! response to ammonium ion is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-03-06T19:33:54Z [Term] id: GO:1904015 name: cellular response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904014 ! response to serotonin created_by: sl creation_date: 2015-03-06T19:34:00Z [Term] id: GO:1904016 name: response to Thyroglobulin triiodothyronine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505] is_a: GO:0010033 ! response to organic substance created_by: sl creation_date: 2015-03-06T19:34:07Z [Term] id: GO:1904017 name: cellular response to Thyroglobulin triiodothyronine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904016 ! response to Thyroglobulin triiodothyronine created_by: sl creation_date: 2015-03-06T19:34:13Z [Term] id: GO:1904018 name: positive regulation of vasculature development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] synonym: "activation of vascular system development" RELATED [GOC:TermGenie] synonym: "activation of vasculature development" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001944 ! vasculature development relationship: positively_regulates GO:0001944 ! vasculature development created_by: sl creation_date: 2015-03-06T22:17:04Z [Term] id: GO:1904019 name: epithelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process created_by: sl creation_date: 2015-03-06T22:27:17Z [Term] id: GO:1904020 name: regulation of G protein-coupled receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] synonym: "regulation of G-protein-coupled receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002031 ! G protein-coupled receptor internalization relationship: regulates GO:0002031 ! G protein-coupled receptor internalization created_by: pga creation_date: 2015-03-10T17:10:45Z [Term] id: GO:1904021 name: negative regulation of G protein-coupled receptor internalization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] synonym: "down regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] synonym: "down-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] synonym: "downregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] synonym: "inhibition of G-protein coupled receptor internalization" NARROW [GOC:TermGenie] synonym: "negative regulation of G-protein coupled receptor internalization" EXACT [] is_a: GO:0002091 ! negative regulation of receptor internalization is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002031 ! G protein-coupled receptor internalization relationship: negatively_regulates GO:0002031 ! G protein-coupled receptor internalization created_by: pga creation_date: 2015-03-10T17:10:50Z [Term] id: GO:1904022 name: positive regulation of G protein-coupled receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] synonym: "activation of G-protein coupled receptor internalization" NARROW [GOC:TermGenie] synonym: "positive regulation of G-protein coupled receptor internalization" EXACT [] synonym: "up regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] synonym: "up-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] synonym: "upregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] is_a: GO:0002092 ! positive regulation of receptor internalization is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002031 ! G protein-coupled receptor internalization relationship: positively_regulates GO:0002031 ! G protein-coupled receptor internalization created_by: pga creation_date: 2015-03-10T17:10:56Z [Term] id: GO:1904023 name: regulation of glucose catabolic process to lactate via pyruvate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] synonym: "regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "regulation of homolactic fermentation" EXACT [GOC:TermGenie] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043465 ! regulation of fermentation is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:1902688 ! regulation of NAD metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate relationship: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate created_by: dph creation_date: 2015-03-11T16:57:32Z [Term] id: GO:1904024 name: negative regulation of glucose catabolic process to lactate via pyruvate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] synonym: "down regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "down regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "down regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "down regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "down regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "down regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "down regulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "down-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "down-regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "down-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "down-regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "down-regulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "downregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "downregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "downregulation of homofermentation" EXACT [GOC:TermGenie] synonym: "downregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "downregulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "downregulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "downregulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "inhibition of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie] synonym: "inhibition of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie] synonym: "inhibition of homofermentation" NARROW [GOC:TermGenie] synonym: "inhibition of homofermentative lactate fermentation" NARROW [GOC:TermGenie] synonym: "inhibition of homofermentative pathway" NARROW [GOC:TermGenie] synonym: "inhibition of homolactate fermentation" NARROW [GOC:TermGenie] synonym: "inhibition of homolactic fermentation" NARROW [GOC:TermGenie] synonym: "negative regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "negative regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "negative regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "negative regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "negative regulation of homolactic fermentation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1901003 ! negative regulation of fermentation is_a: GO:1902689 ! negative regulation of NAD metabolic process is_a: GO:1903579 ! negative regulation of ATP metabolic process is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate relationship: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate created_by: dph creation_date: 2015-03-11T16:57:38Z [Term] id: GO:1904025 name: positive regulation of glucose catabolic process to lactate via pyruvate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] synonym: "activation of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie] synonym: "activation of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie] synonym: "activation of homofermentation" NARROW [GOC:TermGenie] synonym: "activation of homofermentative lactate fermentation" NARROW [GOC:TermGenie] synonym: "activation of homofermentative pathway" NARROW [GOC:TermGenie] synonym: "activation of homolactate fermentation" NARROW [GOC:TermGenie] synonym: "activation of homolactic fermentation" NARROW [GOC:TermGenie] synonym: "positive regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "positive regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "positive regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "positive regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "positive regulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "up regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "up regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "up regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "up regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "up regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "up regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "up regulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "up-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "up-regulation of homofermentation" EXACT [GOC:TermGenie] synonym: "up-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "up-regulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "up-regulation of homolactic fermentation" EXACT [GOC:TermGenie] synonym: "upregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "upregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] synonym: "upregulation of homofermentation" EXACT [GOC:TermGenie] synonym: "upregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] synonym: "upregulation of homofermentative pathway" EXACT [GOC:TermGenie] synonym: "upregulation of homolactate fermentation" EXACT [GOC:TermGenie] synonym: "upregulation of homolactic fermentation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010907 ! positive regulation of glucose metabolic process is_a: GO:1902690 ! positive regulation of NAD metabolic process is_a: GO:1903580 ! positive regulation of ATP metabolic process is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate relationship: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate created_by: dph creation_date: 2015-03-11T16:57:44Z [Term] id: GO:1904026 name: regulation of collagen fibril organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "regulation of collagen fibrillogenesis" RELATED [] synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902903 ! regulation of supramolecular fiber organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030199 ! collagen fibril organization relationship: regulates GO:0030199 ! collagen fibril organization created_by: Anne.Estreicher creation_date: 2015-03-12T12:36:52Z [Term] id: GO:1904027 name: negative regulation of collagen fibril organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030199 ! collagen fibril organization relationship: negatively_regulates GO:0030199 ! collagen fibril organization created_by: Anne.Estreicher creation_date: 2015-03-12T12:36:59Z [Term] id: GO:1904028 name: positive regulation of collagen fibril organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030199 ! collagen fibril organization relationship: positively_regulates GO:0030199 ! collagen fibril organization created_by: Anne.Estreicher creation_date: 2015-03-12T12:37:06Z [Term] id: GO:1904029 name: regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097472 ! cyclin-dependent protein kinase activity relationship: regulates GO:0097472 ! cyclin-dependent protein kinase activity created_by: als creation_date: 2015-03-13T15:43:38Z [Term] id: GO:1904030 name: negative regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] synonym: "inhibition of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097472 ! cyclin-dependent protein kinase activity relationship: negatively_regulates GO:0097472 ! cyclin-dependent protein kinase activity created_by: als creation_date: 2015-03-13T15:43:44Z [Term] id: GO:1904031 name: positive regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] synonym: "activation of cyclin-dependent protein kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097472 ! cyclin-dependent protein kinase activity relationship: positively_regulates GO:0097472 ! cyclin-dependent protein kinase activity created_by: als creation_date: 2015-03-13T15:43:50Z [Term] id: GO:1904032 name: regulation of t-SNARE clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990656 ! t-SNARE clustering relationship: regulates GO:1990656 ! t-SNARE clustering created_by: sl creation_date: 2015-03-13T21:21:38Z [Term] id: GO:1904033 name: negative regulation of t-SNARE clustering namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] synonym: "down regulation of t-SNARE clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of t-SNARE clustering" EXACT [GOC:TermGenie] synonym: "downregulation of t-SNARE clustering" EXACT [GOC:TermGenie] synonym: "inhibition of t-SNARE clustering" NARROW [GOC:TermGenie] is_a: GO:1904032 ! regulation of t-SNARE clustering is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990656 ! t-SNARE clustering relationship: negatively_regulates GO:1990656 ! t-SNARE clustering created_by: sl creation_date: 2015-03-13T21:21:44Z [Term] id: GO:1904034 name: positive regulation of t-SNARE clustering namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] synonym: "activation of t-SNARE clustering" NARROW [GOC:TermGenie] synonym: "up regulation of t-SNARE clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of t-SNARE clustering" EXACT [GOC:TermGenie] synonym: "upregulation of t-SNARE clustering" EXACT [GOC:TermGenie] is_a: GO:1904032 ! regulation of t-SNARE clustering is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990656 ! t-SNARE clustering relationship: positively_regulates GO:1990656 ! t-SNARE clustering created_by: sl creation_date: 2015-03-13T21:21:50Z [Term] id: GO:1904035 name: regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904019 ! epithelial cell apoptotic process relationship: regulates GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2015-03-13T22:05:41Z [Term] id: GO:1904036 name: negative regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904019 ! epithelial cell apoptotic process relationship: negatively_regulates GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2015-03-13T22:05:47Z [Term] id: GO:1904037 name: positive regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904019 ! epithelial cell apoptotic process relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2015-03-13T22:05:53Z [Term] id: GO:1904038 name: regulation of iron export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "regulation of ferrous iron export" NARROW [] synonym: "regulation of iron(2+) export" NARROW [] is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1903988 ! iron ion export across plasma membrane relationship: regulates GO:1903988 ! iron ion export across plasma membrane created_by: klaus.mitchell.14 creation_date: 2015-03-16T15:36:37Z [Term] id: GO:1904039 name: negative regulation of iron export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "down regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "down regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "down-regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "down-regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "downregulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "downregulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie] synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "negative regulation of iron(2+) export" NARROW [] is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1904038 ! regulation of iron export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1903988 ! iron ion export across plasma membrane relationship: negatively_regulates GO:1903988 ! iron ion export across plasma membrane created_by: klaus.mitchell.14 creation_date: 2015-03-16T15:36:43Z [Term] id: GO:1904040 name: positive regulation of iron export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "positive regulation of iron(2+) export" NARROW [] synonym: "up regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "up regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "up-regulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "up-regulation of iron(2+) export" NARROW [GOC:TermGenie] synonym: "upregulation of ferrous iron export" NARROW [GOC:TermGenie] synonym: "upregulation of iron(2+) export" NARROW [GOC:TermGenie] is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1904038 ! regulation of iron export across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1903988 ! iron ion export across plasma membrane relationship: positively_regulates GO:1903988 ! iron ion export across plasma membrane created_by: klaus.mitchell.14 creation_date: 2015-03-16T15:36:49Z [Term] id: GO:1904041 name: regulation of cystathionine beta-synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] synonym: "regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004122 ! cystathionine beta-synthase activity relationship: regulates GO:0004122 ! cystathionine beta-synthase activity created_by: hadil.alrohaif.14 creation_date: 2015-03-16T15:52:41Z [Term] id: GO:1904042 name: negative regulation of cystathionine beta-synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] synonym: "down regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "down regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "down regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "down regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "downregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "inhibition of beta-thionase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cystathionine beta-synthase activity" NARROW [GOC:TermGenie] synonym: "inhibition of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie] synonym: "inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of methylcysteine synthase activity" NARROW [GOC:TermGenie] synonym: "inhibition of serine sulfhydrase activity" NARROW [GOC:TermGenie] synonym: "inhibition of serine sulfhydrylase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] is_a: GO:0051350 ! negative regulation of lyase activity is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004122 ! cystathionine beta-synthase activity relationship: negatively_regulates GO:0004122 ! cystathionine beta-synthase activity created_by: hadil.alrohaif.14 creation_date: 2015-03-16T15:52:47Z [Term] id: GO:1904043 name: positive regulation of cystathionine beta-synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] synonym: "activation of beta-thionase activity" NARROW [GOC:TermGenie] synonym: "activation of cystathionine beta-synthase activity" NARROW [GOC:TermGenie] synonym: "activation of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie] synonym: "activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie] synonym: "activation of methylcysteine synthase activity" NARROW [GOC:TermGenie] synonym: "activation of serine sulfhydrase activity" NARROW [GOC:TermGenie] synonym: "activation of serine sulfhydrylase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "up regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-thionase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] synonym: "upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] synonym: "upregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] is_a: GO:0051349 ! positive regulation of lyase activity is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004122 ! cystathionine beta-synthase activity relationship: positively_regulates GO:0004122 ! cystathionine beta-synthase activity created_by: hadil.alrohaif.14 creation_date: 2015-03-16T15:52:53Z [Term] id: GO:1904044 name: response to aldosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] is_a: GO:0051385 ! response to mineralocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-03-16T23:07:53Z [Term] id: GO:1904045 name: cellular response to aldosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904044 ! response to aldosterone created_by: sl creation_date: 2015-03-16T23:07:59Z [Term] id: GO:1904046 name: negative regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production." [GO_REF:0000058, GOC:TermGenie, PMID:19404486] synonym: "down regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] synonym: "down regulation of VEGF production" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] synonym: "down-regulation of VEGF production" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] synonym: "downregulation of VEGF production" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial growth factor production" NARROW [GOC:TermGenie] synonym: "inhibition of VEGF production" NARROW [GOC:TermGenie] synonym: "negative regulation of VEGF production" EXACT [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0010574 ! regulation of vascular endothelial growth factor production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010573 ! vascular endothelial growth factor production relationship: negatively_regulates GO:0010573 ! vascular endothelial growth factor production created_by: sl creation_date: 2015-03-16T23:27:06Z [Term] id: GO:1904047 name: S-adenosyl-L-methionine binding namespace: molecular_function alt_id: GO:0070283 def: "Interacting selectively and non-covalently with S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361] synonym: "radical SAM enzyme activity" NARROW [] xref: Reactome:R-HSA-947535 "Cyclisation of GTP to precursor Z" is_a: GO:0008144 ! drug binding is_a: GO:0050662 ! coenzyme binding is_a: GO:1901681 ! sulfur compound binding created_by: hadil.alrohaif.14 creation_date: 2015-03-17T10:32:16Z [Term] id: GO:1904048 name: regulation of spontaneous neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). synonym: "regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0150003 ! regulation of spontaneous synaptic transmission intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061669 ! spontaneous neurotransmitter secretion relationship: regulates GO:0061669 ! spontaneous neurotransmitter secretion created_by: pad creation_date: 2015-03-17T10:37:11Z [Term] id: GO:1904049 name: negative regulation of spontaneous neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). synonym: "down regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "down regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "downregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "downregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "inhibition of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie] synonym: "inhibition of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion relationship: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion created_by: pad creation_date: 2015-03-17T10:37:17Z [Term] id: GO:1904050 name: positive regulation of spontaneous neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). synonym: "activation of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie] synonym: "activation of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "up regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "up regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "upregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] synonym: "upregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion relationship: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion created_by: pad creation_date: 2015-03-17T10:37:23Z [Term] id: GO:1904051 name: regulation of protein targeting to vacuole involved in autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). is_a: GO:0010506 ! regulation of autophagy is_a: GO:1903335 ! regulation of vacuolar transport is_a: GO:1903533 ! regulation of protein targeting intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy relationship: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy created_by: pad creation_date: 2015-03-17T13:54:16Z [Term] id: GO:1904052 name: negative regulation of protein targeting to vacuole involved in autophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). synonym: "down regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] synonym: "inhibition of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1903336 ! negative regulation of vacuolar transport is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy relationship: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy created_by: pad creation_date: 2015-03-17T13:54:22Z [Term] id: GO:1904053 name: positive regulation of protein targeting to vacuole involved in autophagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). synonym: "activation of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie] synonym: "up regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1903337 ! positive regulation of vacuolar transport is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy relationship: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy created_by: pad creation_date: 2015-03-17T13:54:27Z [Term] id: GO:1904054 name: regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990705 ! cholangiocyte proliferation relationship: regulates GO:1990705 ! cholangiocyte proliferation created_by: sl creation_date: 2015-03-18T17:56:14Z [Term] id: GO:1904055 name: negative regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990705 ! cholangiocyte proliferation relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation created_by: sl creation_date: 2015-03-18T17:56:20Z [Term] id: GO:1904056 name: positive regulation of cholangiocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie] synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904054 ! regulation of cholangiocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990705 ! cholangiocyte proliferation relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation created_by: sl creation_date: 2015-03-18T17:56:26Z [Term] id: GO:1904057 name: negative regulation of sensory perception of pain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "down regulation of nociception" EXACT [GOC:TermGenie] synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "downregulation of nociception" EXACT [GOC:TermGenie] synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "inhibition of nociception" NARROW [GOC:TermGenie] synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019233 ! sensory perception of pain relationship: negatively_regulates GO:0019233 ! sensory perception of pain created_by: sl creation_date: 2015-03-18T20:33:57Z [Term] id: GO:1904058 name: positive regulation of sensory perception of pain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "activation of nociception" NARROW [GOC:TermGenie] synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of nociception" EXACT [GOC:TermGenie] synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "upregulation of nociception" EXACT [GOC:TermGenie] synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019233 ! sensory perception of pain relationship: positively_regulates GO:0019233 ! sensory perception of pain created_by: sl creation_date: 2015-03-18T20:34:03Z [Term] id: GO:1904059 name: regulation of locomotor rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] is_a: GO:0042752 ! regulation of circadian rhythm is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045475 ! locomotor rhythm relationship: regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:38:52Z [Term] id: GO:1904060 name: negative regulation of locomotor rhythm namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "down regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "down regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "down-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "down-regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "downregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "downregulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "inhibition of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "inhibition of locomotor rhythm" NARROW [GOC:TermGenie] synonym: "negative regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1904059 ! regulation of locomotor rhythm intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045475 ! locomotor rhythm relationship: negatively_regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:38:58Z [Term] id: GO:1904061 name: positive regulation of locomotor rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] synonym: "activation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "activation of locomotor rhythm" NARROW [GOC:TermGenie] synonym: "positive regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "up-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "up-regulation of locomotor rhythm" EXACT [GOC:TermGenie] synonym: "upregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] synonym: "upregulation of locomotor rhythm" EXACT [GOC:TermGenie] is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1904059 ! regulation of locomotor rhythm intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045475 ! locomotor rhythm relationship: positively_regulates GO:0045475 ! locomotor rhythm created_by: sl creation_date: 2015-03-18T20:39:03Z [Term] id: GO:1904062 name: regulation of cation transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] is_a: GO:0034765 ! regulation of ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098655 ! cation transmembrane transport relationship: regulates GO:0098655 ! cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:43Z [Term] id: GO:1904063 name: negative regulation of cation transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098655 ! cation transmembrane transport relationship: negatively_regulates GO:0098655 ! cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:50Z [Term] id: GO:1904064 name: positive regulation of cation transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098655 ! cation transmembrane transport relationship: positively_regulates GO:0098655 ! cation transmembrane transport created_by: sl creation_date: 2015-03-18T21:11:55Z [Term] id: GO:1904065 name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22588719] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission relationship: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission created_by: kmv creation_date: 2015-03-19T15:28:47Z [Term] id: GO:1904066 name: G protein-coupled receptor signaling pathway involved in dauer larval development namespace: biological_process def: "Any G protein-coupled receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789] synonym: "G protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: part_of GO:0040024 ! dauer larval development relationship: part_of GO:0040024 ! dauer larval development created_by: kmv creation_date: 2015-03-20T00:51:06Z [Term] id: GO:1904067 name: ascr#2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789] is_a: GO:0005550 ! pheromone binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: kmv creation_date: 2015-03-20T01:39:04Z [Term] id: GO:1904068 name: G protein-coupled receptor signaling pathway involved in social behavior namespace: biological_process def: "Any G protein-coupled receptor signaling pathway that is involved in social behavior." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789] synonym: "G protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G protein coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signal transduction involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signaling pathway involved in social behavior" EXACT [] synonym: "G-protein coupled receptor signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein coupled receptor signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "G-protein-coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "GPCR signaling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "GPCR signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] synonym: "GPCR signalling pathway involved in social behavior" EXACT [GOC:TermGenie] synonym: "GPCR signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: part_of GO:0035176 ! social behavior relationship: part_of GO:0035176 ! social behavior created_by: kmv creation_date: 2015-03-20T01:51:10Z [Term] id: GO:1904069 name: ascaroside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534] synonym: "ascaroside metabolism" EXACT [GOC:TermGenie] is_a: GO:0016137 ! glycoside metabolic process created_by: kmv creation_date: 2015-03-20T02:40:14Z [Term] id: GO:1904070 name: ascaroside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534] synonym: "ascaroside anabolism" EXACT [GOC:TermGenie] synonym: "ascaroside biosynthesis" EXACT [GOC:TermGenie] synonym: "ascaroside formation" EXACT [GOC:TermGenie] synonym: "ascaroside synthesis" EXACT [GOC:TermGenie] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:1904069 ! ascaroside metabolic process created_by: kmv creation_date: 2015-03-20T02:40:20Z [Term] id: GO:1904071 name: presynaptic active zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GO_REF:0000079, GOC:pr, GOC:TermGenie, PMID:10769383] synonym: "pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "presynaptic active zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:1990709 ! presynaptic active zone organization relationship: part_of GO:0099054 ! presynapse assembly created_by: pr creation_date: 2015-03-20T10:36:27Z [Term] id: GO:1904072 name: presynaptic active zone disassembly namespace: biological_process def: "The disaggregation of a presynaptic active zone into its constituent components." [GO_REF:0000079, GOC:pr, GOC:TermGenie, ISBN:9780387325606] synonym: "pre-synaptic active zone component disassembly" NARROW [GOC:TermGenie] synonym: "pre-synaptic active zone disassembly" EXACT [GOC:TermGenie] is_a: GO:0022411 ! cellular component disassembly is_a: GO:1990709 ! presynaptic active zone organization created_by: pr creation_date: 2015-03-20T10:36:33Z [Term] id: GO:1904073 name: regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001834 ! trophectodermal cell proliferation relationship: regulates GO:0001834 ! trophectodermal cell proliferation created_by: tb creation_date: 2015-03-20T16:55:56Z [Term] id: GO:1904074 name: negative regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001834 ! trophectodermal cell proliferation relationship: negatively_regulates GO:0001834 ! trophectodermal cell proliferation created_by: tb creation_date: 2015-03-20T16:56:02Z [Term] id: GO:1904075 name: positive regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001834 ! trophectodermal cell proliferation relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferation created_by: tb creation_date: 2015-03-20T16:56:08Z [Term] id: GO:1904076 name: regulation of estrogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] synonym: "regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006703 ! estrogen biosynthetic process relationship: regulates GO:0006703 ! estrogen biosynthetic process created_by: tb creation_date: 2015-03-20T16:56:14Z [Term] id: GO:1904077 name: negative regulation of estrogen biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] synonym: "down regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "down regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "down-regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "downregulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of estrogen anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of estrogen biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of estrogen biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of estrogen formation" NARROW [GOC:TermGenie] synonym: "inhibition of estrogen synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of oestrogen biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of oestrogen biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "negative regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:1904076 ! regulation of estrogen biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006703 ! estrogen biosynthetic process relationship: negatively_regulates GO:0006703 ! estrogen biosynthetic process created_by: tb creation_date: 2015-03-20T16:56:20Z [Term] id: GO:1904078 name: positive regulation of estrogen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] synonym: "activation of estrogen anabolism" NARROW [GOC:TermGenie] synonym: "activation of estrogen biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of estrogen biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of estrogen formation" NARROW [GOC:TermGenie] synonym: "activation of estrogen synthesis" NARROW [GOC:TermGenie] synonym: "activation of oestrogen biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of oestrogen biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "positive regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "up regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "up-regulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of estrogen anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of estrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of estrogen formation" EXACT [GOC:TermGenie] synonym: "upregulation of estrogen synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:1904076 ! regulation of estrogen biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006703 ! estrogen biosynthetic process relationship: positively_regulates GO:0006703 ! estrogen biosynthetic process created_by: tb creation_date: 2015-03-20T16:56:26Z [Term] id: GO:1904079 name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process namespace: biological_process def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in negative regulation of neuron apoptotic process." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:20150917] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "negative regulation of global transcription from Pol II promoter involved in neuron survival" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from Pol II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in neuron survival" RELATED [GOC:TermGenie] is_obsolete: true created_by: kmv creation_date: 2015-03-24T17:28:41Z [Term] id: GO:1904080 name: positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron fate specification." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:11959845] synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment is_a: GO:1904081 ! positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0048665 ! neuron fate specification relationship: part_of GO:0048665 ! neuron fate specification created_by: kmv creation_date: 2015-03-24T18:56:50Z [Term] id: GO:1904081 name: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061] synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0030182 ! neuron differentiation created_by: kmv creation_date: 2015-03-24T20:15:59Z [Term] id: GO:1904082 name: pyrimidine nucleobase transmembrane transport namespace: biological_process def: "The process in which pyrimidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0015855 ! pyrimidine nucleobase transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport created_by: tb creation_date: 2015-03-25T00:13:16Z [Term] id: GO:1904083 name: obsolete regulation of epiboly namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of epiboly" EXACT [] is_obsolete: true created_by: dos creation_date: 2015-03-25T10:53:34Z [Term] id: GO:1904084 name: obsolete negative regulation of epiboly namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of epiboly" EXACT [GOC:TermGenie] synonym: "down-regulation of epiboly" EXACT [GOC:TermGenie] synonym: "downregulation of epiboly" EXACT [GOC:TermGenie] synonym: "inhibition of epiboly" NARROW [GOC:TermGenie] synonym: "negative regulation of epiboly" EXACT [] is_obsolete: true created_by: dos creation_date: 2015-03-25T10:53:40Z [Term] id: GO:1904085 name: obsolete positive regulation of epiboly namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of epiboly" NARROW [GOC:TermGenie] synonym: "positive regulation of epiboly" EXACT [] synonym: "up regulation of epiboly" EXACT [GOC:TermGenie] synonym: "up-regulation of epiboly" EXACT [GOC:TermGenie] synonym: "upregulation of epiboly" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2015-03-25T10:53:47Z [Term] id: GO:1904086 name: regulation of epiboly involved in gastrulation with mouth forming second namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second relationship: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second created_by: dos creation_date: 2015-03-25T11:17:34Z [Term] id: GO:1904087 name: negative regulation of epiboly involved in gastrulation with mouth forming second namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] synonym: "down regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] synonym: "down-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] synonym: "downregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] synonym: "inhibition of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie] is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second relationship: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second created_by: dos creation_date: 2015-03-25T11:17:41Z [Term] id: GO:1904088 name: positive regulation of epiboly involved in gastrulation with mouth forming second namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] synonym: "activation of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie] synonym: "up regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] synonym: "up-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] synonym: "upregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second relationship: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second created_by: dos creation_date: 2015-03-25T11:17:47Z [Term] id: GO:1904089 name: negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:20150917] synonym: "negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0043524 ! negative regulation of neuron apoptotic process intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process created_by: pr creation_date: 2015-03-25T21:04:51Z [Term] id: GO:1904090 name: peptidase inhibitor complex namespace: cellular_component def: "A protein complex which is capable of peptidase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624] comment: An example of this is Cystatin-A in human (UniProt symbol P01040) in PMID:20860624 (inferred from physical interaction). synonym: "Cathepsin-B - cystatin-A complex" NARROW [] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2015-03-26T10:16:27Z [Term] id: GO:1904091 name: peptidyl carrier protein activity namespace: molecular_function def: "Binding an amino-acid derived peptidyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the peptidyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. Peptidyl carrier protein (PCP) is involved in nonribosomal peptide biosynthetic process." [GO_REF:0000061, GOC:pr, GOC:TermGenie, GOC:vw, PMID:17502372] comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process. synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie] synonym: "Oligopeptid binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] synonym: "oligopeptide binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie] synonym: "oligopeptide binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie] synonym: "oligopeptides binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie] synonym: "oligopeptido binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] synonym: "peptidyl binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:pr] synonym: "peptidyl binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] synonym: "peptidyl carrier protein" RELATED [GOC:pr] synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis" EXACT [] synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] is_a: GO:0000036 ! acyl carrier activity intersection_of: GO:0000036 ! acyl carrier activity intersection_of: part_of GO:0019184 ! nonribosomal peptide biosynthetic process relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process created_by: pr creation_date: 2015-03-26T10:41:52Z [Term] id: GO:1904092 name: regulation of autophagic cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "regulation of autophagic death" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048102 ! autophagic cell death relationship: regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:32Z [Term] id: GO:1904093 name: negative regulation of autophagic cell death namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:1904092 ! regulation of autophagic cell death intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048102 ! autophagic cell death relationship: negatively_regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:39Z [Term] id: GO:1904094 name: positive regulation of autophagic cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie] synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:1904092 ! regulation of autophagic cell death intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048102 ! autophagic cell death relationship: positively_regulates GO:0048102 ! autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:45Z [Term] id: GO:1904095 name: negative regulation of endosperm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development." [GO_REF:0000058, GOC:TermGenie, PMID:25194028] synonym: "down regulation of endosperm development" EXACT [GOC:TermGenie] synonym: "down-regulation of endosperm development" EXACT [GOC:TermGenie] synonym: "downregulation of endosperm development" EXACT [GOC:TermGenie] synonym: "inhibition of endosperm development" NARROW [GOC:TermGenie] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000014 ! regulation of endosperm development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009960 ! endosperm development relationship: negatively_regulates GO:0009960 ! endosperm development created_by: tb creation_date: 2015-03-26T22:07:25Z [Term] id: GO:1904096 name: protein tyrosine phosphatase complex namespace: cellular_component def: "A protein complex which is capable of protein tyrosine phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22389722] comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction). is_a: GO:1903293 ! phosphatase complex created_by: bhm creation_date: 2015-03-27T14:34:59Z [Term] id: GO:1904097 name: acid phosphatase complex namespace: cellular_component def: "A protein complex which is capable of acid phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:8132635] comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction). is_a: GO:1903293 ! phosphatase complex created_by: bhm creation_date: 2015-03-27T14:36:36Z [Term] id: GO:1904098 name: regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] synonym: "regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006493 ! protein O-linked glycosylation relationship: regulates GO:0006493 ! protein O-linked glycosylation created_by: krc creation_date: 2015-03-27T16:09:58Z [Term] id: GO:1904099 name: negative regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] synonym: "down regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0060051 ! negative regulation of protein glycosylation is_a: GO:1904098 ! regulation of protein O-linked glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006493 ! protein O-linked glycosylation relationship: negatively_regulates GO:0006493 ! protein O-linked glycosylation created_by: krc creation_date: 2015-03-27T16:10:04Z [Term] id: GO:1904100 name: positive regulation of protein O-linked glycosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] synonym: "activation of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "activation of protein O-linked glycosylation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] synonym: "upregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] is_a: GO:0060050 ! positive regulation of protein glycosylation is_a: GO:1904098 ! regulation of protein O-linked glycosylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006493 ! protein O-linked glycosylation relationship: positively_regulates GO:0006493 ! protein O-linked glycosylation created_by: krc creation_date: 2015-03-27T16:10:10Z [Term] id: GO:1904101 name: response to acadesine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: mr creation_date: 2015-03-30T22:36:26Z [Term] id: GO:1904102 name: cellular response to acadesine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904101 ! response to acadesine created_by: mr creation_date: 2015-03-30T22:36:32Z [Term] id: GO:1904103 name: regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060027 ! convergent extension involved in gastrulation relationship: regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:05Z [Term] id: GO:1904104 name: negative regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation relationship: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:12Z [Term] id: GO:1904105 name: positive regulation of convergent extension involved in gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060027 ! convergent extension involved in gastrulation relationship: positively_regulates GO:0060027 ! convergent extension involved in gastrulation created_by: dph creation_date: 2015-04-01T11:17:18Z [Term] id: GO:1904106 name: protein localization to microvillus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization created_by: kmv creation_date: 2015-04-01T18:14:41Z [Term] id: GO:1904107 name: protein localization to microvillus membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microvillus membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in microvillus membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to microvillus membrane" EXACT [GOC:TermGenie] synonym: "protein localization in microvillus membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1904106 ! protein localization to microvillus is_a: GO:1990778 ! protein localization to cell periphery created_by: kmv creation_date: 2015-04-01T18:14:48Z [Term] id: GO:1904108 name: protein localization to ciliary inversin compartment namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in ciliary inversin compartment" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary inversin compartment" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary inversin compartment" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium created_by: kmv creation_date: 2015-04-01T20:54:26Z [Term] id: GO:1904109 name: positive regulation of cholesterol import namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholesterol import." [GO_REF:0000058, GOC:TermGenie, PMID:16772292] synonym: "activation of cholesterol import" NARROW [GOC:TermGenie] synonym: "activation of cholesterol uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of cholesterol uptake" EXACT [GOC:TermGenie] synonym: "up regulation of cholesterol import" EXACT [GOC:TermGenie] synonym: "up regulation of cholesterol uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of cholesterol import" EXACT [GOC:TermGenie] synonym: "up-regulation of cholesterol uptake" EXACT [GOC:TermGenie] synonym: "upregulation of cholesterol import" EXACT [GOC:TermGenie] synonym: "upregulation of cholesterol uptake" EXACT [GOC:TermGenie] is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:0060620 ! regulation of cholesterol import is_a: GO:2000911 ! positive regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070508 ! cholesterol import relationship: positively_regulates GO:0070508 ! cholesterol import created_by: sl creation_date: 2015-04-03T14:39:06Z [Term] id: GO:1904110 name: regulation of plus-end directed microfilament motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] synonym: "regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] is_a: GO:0120079 ! regulation of microfilament motor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060002 ! plus-end directed microfilament motor activity relationship: regulates GO:0060002 ! plus-end directed microfilament motor activity created_by: kmv creation_date: 2015-04-03T18:28:24Z [Term] id: GO:1904111 name: negative regulation of plus-end directed microfilament motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] synonym: "down regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "down regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "down regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "down regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "down-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] synonym: "downregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "downregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "downregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "downregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] synonym: "inhibition of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie] synonym: "inhibition of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "inhibition of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie] synonym: "inhibition of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "negative regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] is_a: GO:0120080 ! negative regulation of microfilament motor activity is_a: GO:1904110 ! regulation of plus-end directed microfilament motor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060002 ! plus-end directed microfilament motor activity relationship: negatively_regulates GO:0060002 ! plus-end directed microfilament motor activity created_by: kmv creation_date: 2015-04-03T18:28:30Z [Term] id: GO:1904112 name: positive regulation of plus-end directed microfilament motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] synonym: "activation of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie] synonym: "activation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "activation of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie] synonym: "activation of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "positive regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "up regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "up regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "up regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "up regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "up-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] synonym: "upregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "upregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] synonym: "upregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] synonym: "upregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] is_a: GO:0120081 ! positive regulation of microfilament motor activity is_a: GO:1904110 ! regulation of plus-end directed microfilament motor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060002 ! plus-end directed microfilament motor activity relationship: positively_regulates GO:0060002 ! plus-end directed microfilament motor activity created_by: kmv creation_date: 2015-04-03T18:28:35Z [Term] id: GO:1904113 name: negative regulation of muscle filament sliding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181] synonym: "down regulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "down-regulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "downregulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "inhibition of muscle filament sliding" NARROW [GOC:TermGenie] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0045932 ! negative regulation of muscle contraction is_a: GO:0051271 ! negative regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030049 ! muscle filament sliding relationship: negatively_regulates GO:0030049 ! muscle filament sliding created_by: kmv creation_date: 2015-04-03T18:40:38Z [Term] id: GO:1904114 name: positive regulation of muscle filament sliding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181] synonym: "activation of muscle filament sliding" NARROW [GOC:TermGenie] synonym: "up regulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "up-regulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "upregulation of muscle filament sliding" EXACT [GOC:TermGenie] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0045933 ! positive regulation of muscle contraction is_a: GO:1903116 ! positive regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030049 ! muscle filament sliding relationship: positively_regulates GO:0030049 ! muscle filament sliding created_by: kmv creation_date: 2015-04-03T18:40:44Z [Term] id: GO:1904115 name: axon cytoplasm namespace: cellular_component def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] synonym: "axoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0030424 ! axon relationship: part_of GO:0030424 ! axon created_by: sl creation_date: 2015-04-06T18:13:14Z [Term] id: GO:1904116 name: response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-04-06T19:39:42Z [Term] id: GO:1904117 name: cellular response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1904116 ! response to vasopressin created_by: sl creation_date: 2015-04-06T19:39:48Z [Term] id: GO:1904118 name: regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071600 ! otic vesicle morphogenesis relationship: regulates GO:0071600 ! otic vesicle morphogenesis created_by: pga creation_date: 2015-04-07T14:00:56Z [Term] id: GO:1904119 name: negative regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] synonym: "down regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of otic vesicle morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1904118 ! regulation of otic vesicle morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071600 ! otic vesicle morphogenesis relationship: negatively_regulates GO:0071600 ! otic vesicle morphogenesis created_by: pga creation_date: 2015-04-07T14:01:02Z [Term] id: GO:1904120 name: positive regulation of otic vesicle morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] synonym: "activation of otic vesicle morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1904118 ! regulation of otic vesicle morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071600 ! otic vesicle morphogenesis relationship: positively_regulates GO:0071600 ! otic vesicle morphogenesis created_by: pga creation_date: 2015-04-07T14:01:08Z [Term] id: GO:1904121 name: phosphatidylethanolamine transfer activity namespace: molecular_function def: "Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GO_REF:0000066, GOC:TermGenie, PMID:8606365] synonym: "intermembrane phosphatidylethanolamine transfer activity" NARROW [] synonym: "phosphatidylethanolamine carrier activity" EXACT [] synonym: "phosphatidylethanolamine transporter activity" BROAD [] is_a: GO:0120014 ! phospholipid transfer activity created_by: sl creation_date: 2015-04-07T22:51:34Z [Term] id: GO:1904122 name: positive regulation of fatty acid beta-oxidation by octopamine signaling pathway namespace: biological_process def: "An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942] synonym: "activation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie] synonym: "stimulation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation is_a: GO:0071927 ! octopamine signaling pathway intersection_of: GO:0071927 ! octopamine signaling pathway intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation created_by: kmv creation_date: 2015-04-08T21:03:13Z [Term] id: GO:1904123 name: positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway namespace: biological_process def: "A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942] synonym: "activation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0007210 ! serotonin receptor signaling pathway is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation intersection_of: GO:0007210 ! serotonin receptor signaling pathway intersection_of: positively_regulates GO:0006635 ! fatty acid beta-oxidation created_by: kmv creation_date: 2015-04-08T21:03:20Z [Term] id: GO:1904124 name: microglial cell migration namespace: biological_process def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0008347 ! glial cell migration is_a: GO:1905517 ! macrophage migration created_by: nc creation_date: 2015-04-10T16:04:49Z [Term] id: GO:1904125 name: convergent extension involved in rhombomere morphogenesis namespace: biological_process def: "Any convergent extension that is involved in rhombomere morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021593 ! rhombomere morphogenesis created_by: dph creation_date: 2015-04-10T21:12:50Z [Term] id: GO:1904126 name: convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any convergent extension that is involved in notochord morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis intersection_of: GO:0060026 ! convergent extension intersection_of: part_of GO:0048570 ! notochord morphogenesis relationship: part_of GO:0048570 ! notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:12:57Z [Term] id: GO:1904127 name: regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0014807 ! regulation of somitogenesis is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:04Z [Term] id: GO:1904128 name: negative regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] is_a: GO:1901233 ! negative regulation of convergent extension involved in axis elongation is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:10Z [Term] id: GO:1904129 name: positive regulation of convergent extension involved in somitogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] is_a: GO:1901234 ! positive regulation of convergent extension involved in axis elongation is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis relationship: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis created_by: dph creation_date: 2015-04-10T21:13:15Z [Term] id: GO:1904130 name: regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:21Z [Term] id: GO:1904131 name: negative regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:27Z [Term] id: GO:1904132 name: positive regulation of convergent extension involved in neural plate elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation relationship: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation created_by: dph creation_date: 2015-04-10T21:13:33Z [Term] id: GO:1904133 name: regulation of convergent extension involved in rhombomere morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis relationship: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis created_by: dph creation_date: 2015-04-10T21:21:12Z [Term] id: GO:1904134 name: negative regulation of convergent extension involved in rhombomere morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis relationship: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis created_by: dph creation_date: 2015-04-10T21:21:18Z [Term] id: GO:1904135 name: positive regulation of convergent extension involved in rhombomere morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis relationship: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis created_by: dph creation_date: 2015-04-10T21:21:24Z [Term] id: GO:1904136 name: regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:30Z [Term] id: GO:1904137 name: negative regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "down regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:36Z [Term] id: GO:1904138 name: positive regulation of convergent extension involved in notochord morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] synonym: "activation of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis relationship: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis created_by: dph creation_date: 2015-04-10T21:21:41Z [Term] id: GO:1904139 name: regulation of microglial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:1903975 ! regulation of glial cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904124 ! microglial cell migration relationship: regulates GO:1904124 ! microglial cell migration created_by: nc creation_date: 2015-04-13T09:06:57Z [Term] id: GO:1904140 name: negative regulation of microglial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie] is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904124 ! microglial cell migration relationship: negatively_regulates GO:1904124 ! microglial cell migration created_by: nc creation_date: 2015-04-13T09:07:03Z [Term] id: GO:1904141 name: positive regulation of microglial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie] is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904124 ! microglial cell migration relationship: positively_regulates GO:1904124 ! microglial cell migration created_by: nc creation_date: 2015-04-13T09:07:11Z [Term] id: GO:1904142 name: negative regulation of carotenoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] synonym: "down regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "down regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "downregulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of carotenoid anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid formation" NARROW [GOC:TermGenie] synonym: "inhibition of carotenoid synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of carotenoid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016117 ! carotenoid biosynthetic process relationship: negatively_regulates GO:0016117 ! carotenoid biosynthetic process created_by: tb creation_date: 2015-04-13T19:39:13Z [Term] id: GO:1904143 name: positive regulation of carotenoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] synonym: "activation of carotenoid anabolism" NARROW [GOC:TermGenie] synonym: "activation of carotenoid biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of carotenoid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of carotenoid formation" NARROW [GOC:TermGenie] synonym: "activation of carotenoid synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "up regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid formation" EXACT [GOC:TermGenie] synonym: "upregulation of carotenoid synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016117 ! carotenoid biosynthetic process relationship: positively_regulates GO:0016117 ! carotenoid biosynthetic process created_by: tb creation_date: 2015-04-13T19:39:19Z [Term] id: GO:1904144 name: phosphatidylinositol phosphate phosphatase complex namespace: cellular_component def: "A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165] comment: An example of this is ACPP in human (P15309) in PMID:12525165 (inferred from physical interaction). synonym: "prostatic acid phosphatase complex" NARROW [] is_a: GO:1903293 ! phosphatase complex created_by: bhm creation_date: 2015-04-14T11:22:53Z [Term] id: GO:1904145 name: negative regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1900194 ! negative regulation of oocyte maturation is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation created_by: tb creation_date: 2015-04-14T15:59:22Z [Term] id: GO:1904146 name: positive regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1900195 ! positive regulation of oocyte maturation is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation created_by: tb creation_date: 2015-04-14T15:59:28Z [Term] id: GO:1904147 name: response to nonylphenol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726] is_a: GO:0010033 ! response to organic substance created_by: sl creation_date: 2015-04-14T17:01:44Z [Term] id: GO:1904148 name: cellular response to nonylphenol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904147 ! response to nonylphenol created_by: sl creation_date: 2015-04-14T17:01:50Z [Term] id: GO:1904149 name: regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090634 ! microglial cell mediated cytotoxicity relationship: regulates GO:0090634 ! microglial cell mediated cytotoxicity created_by: nc creation_date: 2015-04-15T08:05:29Z [Term] id: GO:1904150 name: negative regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity relationship: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity created_by: nc creation_date: 2015-04-15T08:05:35Z [Term] id: GO:1904151 name: positive regulation of microglial cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity relationship: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity created_by: nc creation_date: 2015-04-15T08:05:42Z [Term] id: GO:1904152 name: regulation of retrograde protein transport, ER to cytosol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] synonym: "regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "regulation of protein retrotranslocation from ER" EXACT [GOC:bf] synonym: "regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum is_a: GO:1904292 ! regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030970 ! retrograde protein transport, ER to cytosol relationship: regulates GO:0030970 ! retrograde protein transport, ER to cytosol created_by: bf creation_date: 2015-04-15T09:23:06Z [Term] id: GO:1904153 name: negative regulation of retrograde protein transport, ER to cytosol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] synonym: "down regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] synonym: "down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] synonym: "downregulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] synonym: "inhibition of protein dislocation from ER" NARROW [GOC:TermGenie] synonym: "inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie] synonym: "inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie] synonym: "negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "negative regulation of protein retrotranslocation from ER" EXACT [GOC:bf] synonym: "negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] is_a: GO:0070862 ! negative regulation of protein exit from endoplasmic reticulum is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol is_a: GO:1904293 ! negative regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol relationship: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol created_by: bf creation_date: 2015-04-15T09:23:13Z [Term] id: GO:1904154 name: positive regulation of retrograde protein transport, ER to cytosol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] synonym: "activation of protein dislocation from ER" NARROW [GOC:TermGenie] synonym: "activation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie] synonym: "activation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie] synonym: "positive regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "positive regulation of protein retrotranslocation from ER" EXACT [GOC:bf] synonym: "positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "up regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "up regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "up regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] synonym: "up-regulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "up-regulation of protein retrotranslocation from ER" EXACT [GOC:bf] synonym: "up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] synonym: "upregulation of protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] is_a: GO:0070863 ! positive regulation of protein exit from endoplasmic reticulum is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol is_a: GO:1904294 ! positive regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol relationship: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol created_by: bf creation_date: 2015-04-15T09:23:19Z [Term] id: GO:1904155 name: DN2 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus created_by: dph creation_date: 2015-04-15T12:52:53Z [Term] id: GO:1904156 name: DN3 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus created_by: dph creation_date: 2015-04-15T12:53:00Z [Term] id: GO:1904157 name: DN4 thymocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] is_a: GO:0033077 ! T cell differentiation in thymus created_by: dph creation_date: 2015-04-15T12:53:07Z [Term] id: GO:1904158 name: axonemal central apparatus assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136] synonym: "axonemal central apparatus formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0035082 ! axoneme assembly created_by: krc creation_date: 2015-04-16T18:46:11Z [Term] id: GO:1904159 name: megasporocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte." [GO_REF:0000086, GOC:tair_curators, GOC:TermGenie] comment: The process aimed at the progression of a megasporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A megasporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) megaspores; also called megaspore mother cell. synonym: "megaspore mother cell differentiation" EXACT [GOC:tair_curators] is_a: GO:0048533 ! sporocyte differentiation created_by: lr creation_date: 2015-04-17T20:25:14Z [Term] id: GO:1904160 name: protein localization to chloroplast starch grain namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain." [GO_REF:0000087, GOC:TermGenie, PMID:25710501] synonym: "protein localisation in chloroplast starch grain" EXACT [GOC:TermGenie] synonym: "protein localisation to chloroplast starch grain" EXACT [GOC:TermGenie] synonym: "protein localization in chloroplast starch grain" EXACT [GOC:TermGenie] is_a: GO:0072598 ! protein localization to chloroplast created_by: lr creation_date: 2015-04-20T18:06:17Z [Term] id: GO:1904161 name: DNA synthesis involved in UV-damage excision repair namespace: biological_process def: "Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216] synonym: "DNA synthesis during UV-damage excision repair" RELATED [GOC:TermGenie] synonym: "DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair" RELATED [GOC:TermGenie] synonym: "DNA synthesis during UVDE-dependent excision repair" RELATED [GOC:TermGenie] synonym: "DNA synthesis during UVER" RELATED [GOC:TermGenie] synonym: "DNA synthesis involved in AER" RELATED [GOC:mah, PMID:10704216] synonym: "DNA synthesis involved in alternative excision repair" RELATED [GOC:mah, PMID:10704216] synonym: "DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in UVER" EXACT [GOC:TermGenie] synonym: "mitotic DNA repair synthesis involved in UV-damage excision repair" NARROW [GOC:TermGenie] synonym: "mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" NARROW [GOC:TermGenie] synonym: "mitotic DNA repair synthesis involved in UVDE-dependent excision repair" NARROW [GOC:TermGenie] synonym: "mitotic DNA repair synthesis involved in UVER" NARROW [GOC:TermGenie] is_a: GO:0000731 ! DNA synthesis involved in DNA repair intersection_of: GO:0000731 ! DNA synthesis involved in DNA repair intersection_of: part_of GO:0070914 ! UV-damage excision repair relationship: part_of GO:0070914 ! UV-damage excision repair created_by: mah creation_date: 2015-04-21T14:53:12Z [Term] id: GO:1904162 name: 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair namespace: molecular_function def: "Any 5'-3' exodeoxyribonuclease activity that is involved in UV-damage excision repair." [GO_REF:0000061, GOC:TermGenie, PMID:10704216] synonym: "5'-3' exodeoxyribonuclease activity involved in AER" RELATED [GOC:mah] synonym: "5'-3' exodeoxyribonuclease activity involved in alternative excision repair" RELATED [GOC:mah] synonym: "5'-3' exodeoxyribonuclease activity involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie] synonym: "5'-3' exodeoxyribonuclease activity involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie] synonym: "5'-3' exodeoxyribonuclease activity involved in UVER" EXACT [GOC:TermGenie] is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity intersection_of: GO:0035312 ! 5'-3' exodeoxyribonuclease activity intersection_of: part_of GO:0070914 ! UV-damage excision repair relationship: part_of GO:0070914 ! UV-damage excision repair created_by: mah creation_date: 2015-04-21T14:53:19Z [Term] id: GO:1904163 name: obsolete regulation of triglyceride homeostasis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] is_obsolete: true created_by: rph creation_date: 2015-04-22T11:04:43Z [Term] id: GO:1904164 name: obsolete negative regulation of triglyceride homeostasis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "down regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] synonym: "downregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "downregulation of triglyceride homeostasis" EXACT [GOC:TermGenie] synonym: "inhibition of triacylglycerol homeostasis" NARROW [GOC:TermGenie] synonym: "inhibition of triglyceride homeostasis" NARROW [GOC:TermGenie] synonym: "negative regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] is_obsolete: true created_by: rph creation_date: 2015-04-22T11:04:49Z [Term] id: GO:1904165 name: obsolete positive regulation of triglyceride homeostasis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of triacylglycerol homeostasis" NARROW [GOC:TermGenie] synonym: "activation of triglyceride homeostasis" NARROW [GOC:TermGenie] synonym: "positive regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "up regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "up regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "up-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] synonym: "upregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] synonym: "upregulation of triglyceride homeostasis" EXACT [GOC:TermGenie] is_obsolete: true created_by: rph creation_date: 2015-04-22T11:04:55Z [Term] id: GO:1904166 name: obsolete negative regulation of cholesterol homeostasis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of cholesterol homeostasis" EXACT [GOC:TermGenie] synonym: "down-regulation of cholesterol homeostasis" EXACT [GOC:TermGenie] synonym: "downregulation of cholesterol homeostasis" EXACT [GOC:TermGenie] synonym: "inhibition of cholesterol homeostasis" NARROW [GOC:TermGenie] is_obsolete: true created_by: rph creation_date: 2015-04-22T11:11:12Z [Term] id: GO:1904170 name: regulation of bleb assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032060 ! bleb assembly relationship: regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:19Z [Term] id: GO:1904171 name: negative regulation of bleb assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032060 ! bleb assembly relationship: negatively_regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:25Z [Term] id: GO:1904172 name: positive regulation of bleb assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032060 ! bleb assembly relationship: positively_regulates GO:0032060 ! bleb assembly created_by: als creation_date: 2015-04-23T09:32:31Z [Term] id: GO:1904173 name: regulation of histone demethylase activity (H3-K4 specific) namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) relationship: regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) created_by: dph creation_date: 2015-04-24T19:29:32Z [Term] id: GO:1904174 name: negative regulation of histone demethylase activity (H3-K4 specific) namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] synonym: "down regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] synonym: "down-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] synonym: "downregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] synonym: "inhibition of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific) intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) relationship: negatively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) created_by: dph creation_date: 2015-04-24T19:29:38Z [Term] id: GO:1904175 name: positive regulation of histone demethylase activity (H3-K4 specific) namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] synonym: "activation of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie] synonym: "up regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] synonym: "up-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] synonym: "upregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific) intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) relationship: positively_regulates GO:0032453 ! histone demethylase activity (H3-K4 specific) created_by: dph creation_date: 2015-04-24T19:29:45Z [Term] id: GO:1904176 name: carbon phosphorus lyase complex namespace: cellular_component def: "A protein complex which is capable of carbon phosphorus lyase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682] comment: An example of this is PhnJ in E. coli (P16688) in PMID:22089136 (inferred from direct assay). xref: IntAct:EBI-6471348 is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2015-04-29T08:17:13Z [Term] id: GO:1904177 name: regulation of adipose tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060612 ! adipose tissue development relationship: regulates GO:0060612 ! adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:01Z [Term] id: GO:1904178 name: negative regulation of adipose tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie] synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060612 ! adipose tissue development relationship: negatively_regulates GO:0060612 ! adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:07Z [Term] id: GO:1904179 name: positive regulation of adipose tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "activation of adipogenesis" RELATED [GOC:TermGenie] synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie] synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060612 ! adipose tissue development relationship: positively_regulates GO:0060612 ! adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:13Z [Term] id: GO:1904180 name: negative regulation of membrane depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "down regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization" NARROW [GOC:TermGenie] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051899 ! membrane depolarization relationship: negatively_regulates GO:0051899 ! membrane depolarization created_by: sl creation_date: 2015-04-29T22:29:25Z [Term] id: GO:1904181 name: positive regulation of membrane depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "activation of membrane depolarization" NARROW [GOC:TermGenie] synonym: "up regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization" EXACT [GOC:TermGenie] is_a: GO:0003254 ! regulation of membrane depolarization is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051899 ! membrane depolarization relationship: positively_regulates GO:0051899 ! membrane depolarization created_by: sl creation_date: 2015-04-29T22:29:31Z [Term] id: GO:1904182 name: regulation of pyruvate dehydrogenase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] synonym: "regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004738 ! pyruvate dehydrogenase activity relationship: regulates GO:0004738 ! pyruvate dehydrogenase activity created_by: dph creation_date: 2015-05-05T14:17:27Z [Term] id: GO:1904183 name: negative regulation of pyruvate dehydrogenase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] synonym: "down regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "inhibition of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004738 ! pyruvate dehydrogenase activity relationship: negatively_regulates GO:0004738 ! pyruvate dehydrogenase activity created_by: dph creation_date: 2015-05-05T14:17:33Z [Term] id: GO:1904184 name: positive regulation of pyruvate dehydrogenase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] synonym: "activation of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004738 ! pyruvate dehydrogenase activity relationship: positively_regulates GO:0004738 ! pyruvate dehydrogenase activity created_by: dph creation_date: 2015-05-05T14:17:39Z [Term] id: GO:1904185 name: equatorial microtubule organizing center assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO_REF:0000079, GOC:TermGenie, PMID:15004232] synonym: "EMTOC assembly" EXACT [GOC:TermGenie] synonym: "EMTOC formation" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organising centre assembly" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organising centre formation" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organizing center formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031023 ! microtubule organizing center organization created_by: mah creation_date: 2015-05-05T14:24:30Z [Term] id: GO:1904186 name: post-anaphase microtubule array organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array." [GO_REF:000103, GOC:TermGenie, PMID:15004232] synonym: "PAA organization" EXACT [GOC:TermGenie] synonym: "post-anaphase array organization" EXACT [GOC:TermGenie] synonym: "post-anaphase microtubule array organisation" EXACT [] is_a: GO:0016043 ! cellular component organization created_by: mah creation_date: 2015-05-05T14:40:16Z [Term] id: GO:1904187 name: regulation of transformation of host cell by virus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] synonym: "regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "regulation of viral transformation of host cell" EXACT [GOC:TermGenie] is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019087 ! transformation of host cell by virus relationship: regulates GO:0019087 ! transformation of host cell by virus created_by: pga creation_date: 2015-05-05T15:29:58Z [Term] id: GO:1904188 name: negative regulation of transformation of host cell by virus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] synonym: "down regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "down regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "down regulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "down-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "down-regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "down-regulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "downregulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "downregulation of viral transformation" EXACT [GOC:TermGenie] synonym: "downregulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "inhibition of transformation of host cell by virus" NARROW [GOC:TermGenie] synonym: "inhibition of viral transformation" NARROW [GOC:TermGenie] synonym: "inhibition of viral transformation of host cell" NARROW [GOC:TermGenie] synonym: "negative regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "negative regulation of viral transformation of host cell" EXACT [GOC:TermGenie] is_a: GO:0048525 ! negative regulation of viral process is_a: GO:1904187 ! regulation of transformation of host cell by virus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019087 ! transformation of host cell by virus relationship: negatively_regulates GO:0019087 ! transformation of host cell by virus created_by: pga creation_date: 2015-05-05T15:30:04Z [Term] id: GO:1904189 name: positive regulation of transformation of host cell by virus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] synonym: "activation of transformation of host cell by virus" NARROW [GOC:TermGenie] synonym: "activation of viral transformation" NARROW [GOC:TermGenie] synonym: "activation of viral transformation of host cell" NARROW [GOC:TermGenie] synonym: "positive regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "positive regulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "up regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "up regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "up regulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "up-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "up-regulation of viral transformation" EXACT [GOC:TermGenie] synonym: "up-regulation of viral transformation of host cell" EXACT [GOC:TermGenie] synonym: "upregulation of transformation of host cell by virus" EXACT [GOC:TermGenie] synonym: "upregulation of viral transformation" EXACT [GOC:TermGenie] synonym: "upregulation of viral transformation of host cell" EXACT [GOC:TermGenie] is_a: GO:0048524 ! positive regulation of viral process is_a: GO:1904187 ! regulation of transformation of host cell by virus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019087 ! transformation of host cell by virus relationship: positively_regulates GO:0019087 ! transformation of host cell by virus created_by: pga creation_date: 2015-05-05T15:30:11Z [Term] id: GO:1904191 name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division namespace: biological_process def: "Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division." [GO_REF:0000060, GOC:TermGenie, PMID:15791259] synonym: "activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie] synonym: "positive regulation of CDK activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin-dependent protein kinase activity involved in meiosis" BROAD [GOC:TermGenie] synonym: "stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie] synonym: "up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] synonym: "upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity intersection_of: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity intersection_of: regulates GO:0140013 ! meiotic nuclear division created_by: al creation_date: 2015-05-06T14:48:52Z [Term] id: GO:1904192 name: regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902488 ! cholangiocyte apoptotic process relationship: regulates GO:1902488 ! cholangiocyte apoptotic process created_by: sl creation_date: 2015-05-06T15:25:48Z [Term] id: GO:1904193 name: negative regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process created_by: sl creation_date: 2015-05-06T15:25:55Z [Term] id: GO:1904194 name: positive regulation of cholangiocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902488 ! cholangiocyte apoptotic process relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process created_by: sl creation_date: 2015-05-06T15:26:00Z [Term] id: GO:1904195 name: regulation of granulosa cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990739 ! granulosa cell proliferation relationship: regulates GO:1990739 ! granulosa cell proliferation created_by: sl creation_date: 2015-05-07T17:02:25Z [Term] id: GO:1904196 name: negative regulation of granulosa cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] synonym: "down regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of granulosa cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904195 ! regulation of granulosa cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990739 ! granulosa cell proliferation relationship: negatively_regulates GO:1990739 ! granulosa cell proliferation created_by: sl creation_date: 2015-05-07T17:02:34Z [Term] id: GO:1904197 name: positive regulation of granulosa cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] synonym: "activation of granulosa cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904195 ! regulation of granulosa cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990739 ! granulosa cell proliferation relationship: positively_regulates GO:1990739 ! granulosa cell proliferation created_by: sl creation_date: 2015-05-07T17:02:40Z [Term] id: GO:1904198 name: negative regulation of regulation of vascular smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization relationship: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization created_by: sl creation_date: 2015-05-07T17:16:44Z [Term] id: GO:1904199 name: positive regulation of regulation of vascular smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization relationship: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization created_by: sl creation_date: 2015-05-07T17:16:50Z [Term] id: GO:1904200 name: iodide transmembrane transport namespace: biological_process def: "The process in which iodide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20392814] is_a: GO:0015705 ! iodide transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: sl creation_date: 2015-05-08T15:17:19Z [Term] id: GO:1904201 name: regulation of iodide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015705 ! iodide transport relationship: regulates GO:0015705 ! iodide transport created_by: sl creation_date: 2015-05-08T15:19:57Z [Term] id: GO:1904202 name: negative regulation of iodide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] synonym: "down regulation of iodide transport" EXACT [GOC:TermGenie] synonym: "down-regulation of iodide transport" EXACT [GOC:TermGenie] synonym: "downregulation of iodide transport" EXACT [GOC:TermGenie] synonym: "inhibition of iodide transport" NARROW [GOC:TermGenie] is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:1904201 ! regulation of iodide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015705 ! iodide transport relationship: negatively_regulates GO:0015705 ! iodide transport created_by: sl creation_date: 2015-05-08T15:20:03Z [Term] id: GO:1904203 name: positive regulation of iodide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] synonym: "activation of iodide transport" NARROW [GOC:TermGenie] synonym: "up regulation of iodide transport" EXACT [GOC:TermGenie] synonym: "up-regulation of iodide transport" EXACT [GOC:TermGenie] synonym: "upregulation of iodide transport" EXACT [GOC:TermGenie] is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:1904201 ! regulation of iodide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015705 ! iodide transport relationship: positively_regulates GO:0015705 ! iodide transport created_by: sl creation_date: 2015-05-08T15:20:09Z [Term] id: GO:1904204 name: regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] is_a: GO:0014733 ! regulation of skeletal muscle adaptation is_a: GO:0014743 ! regulation of muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014734 ! skeletal muscle hypertrophy relationship: regulates GO:0014734 ! skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:13Z [Term] id: GO:1904205 name: negative regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy relationship: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:19Z [Term] id: GO:1904206 name: positive regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014734 ! skeletal muscle hypertrophy relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:25Z [Term] id: GO:1904207 name: regulation of chemokine (C-C motif) ligand 2 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] synonym: "regulation of CCL2 secretion" EXACT [GOC:TermGenie] is_a: GO:0090196 ! regulation of chemokine secretion is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion relationship: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion created_by: sl creation_date: 2015-05-11T16:47:07Z [Term] id: GO:1904208 name: negative regulation of chemokine (C-C motif) ligand 2 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] synonym: "down regulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of CCL2 secretion" EXACT [GOC:TermGenie] is_a: GO:0090198 ! negative regulation of chemokine secretion is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion is_a: GO:2000342 ! negative regulation of chemokine (C-X-C motif) ligand 2 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion relationship: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion created_by: sl creation_date: 2015-05-11T16:47:13Z [Term] id: GO:1904209 name: positive regulation of chemokine (C-C motif) ligand 2 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] synonym: "activation of CCL2 secretion" NARROW [GOC:TermGenie] synonym: "activation of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of CCL2 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] is_a: GO:0090197 ! positive regulation of chemokine secretion is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion is_a: GO:2000343 ! positive regulation of chemokine (C-X-C motif) ligand 2 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion relationship: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion created_by: sl creation_date: 2015-05-11T16:47:19Z [Term] id: GO:1904210 name: VCP-NPL4-UFD1 AAA ATPase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: bf creation_date: 2015-05-14T10:34:36Z [Term] id: GO:1904211 name: membrane protein proteolysis involved in retrograde protein transport, ER to cytosol namespace: biological_process def: "Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22795130] synonym: "intramembrane cleavage of ERAD substrate" BROAD [PMID:22795130] synonym: "intramembrane proteolysis involved in ERAD" EXACT [PMID:22795130] synonym: "membrane protein proteolysis involved in protein dislocation from ER" EXACT [GOC:TermGenie] synonym: "membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol" EXACT [GOC:TermGenie] synonym: "membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] is_a: GO:0033619 ! membrane protein proteolysis is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process intersection_of: GO:0033619 ! membrane protein proteolysis intersection_of: part_of GO:0030970 ! retrograde protein transport, ER to cytosol relationship: part_of GO:0030970 ! retrograde protein transport, ER to cytosol created_by: bf creation_date: 2015-05-14T15:26:44Z [Term] id: GO:1904212 name: regulation of iodide transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport is_a: GO:1904201 ! regulation of iodide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904200 ! iodide transmembrane transport relationship: regulates GO:1904200 ! iodide transmembrane transport created_by: sl creation_date: 2015-05-14T19:00:02Z [Term] id: GO:1904213 name: negative regulation of iodide transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] synonym: "down regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] synonym: "down-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] synonym: "downregulation of iodide transmembrane transport" EXACT [GOC:TermGenie] synonym: "inhibition of iodide transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport is_a: GO:1904202 ! negative regulation of iodide transport is_a: GO:1904212 ! regulation of iodide transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904200 ! iodide transmembrane transport relationship: negatively_regulates GO:1904200 ! iodide transmembrane transport created_by: sl creation_date: 2015-05-14T19:00:08Z [Term] id: GO:1904214 name: positive regulation of iodide transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] synonym: "activation of iodide transmembrane transport" NARROW [GOC:TermGenie] synonym: "up regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of iodide transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport is_a: GO:1904203 ! positive regulation of iodide transport is_a: GO:1904212 ! regulation of iodide transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904200 ! iodide transmembrane transport relationship: positively_regulates GO:1904200 ! iodide transmembrane transport created_by: sl creation_date: 2015-05-14T19:00:14Z [Term] id: GO:1904215 name: regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:1903533 ! regulation of protein targeting is_a: GO:1904589 ! regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045037 ! protein import into chloroplast stroma relationship: regulates GO:0045037 ! protein import into chloroplast stroma created_by: tb creation_date: 2015-05-15T00:47:48Z [Term] id: GO:1904216 name: positive regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie] synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1904215 ! regulation of protein import into chloroplast stroma is_a: GO:1904591 ! positive regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045037 ! protein import into chloroplast stroma relationship: positively_regulates GO:0045037 ! protein import into chloroplast stroma created_by: tb creation_date: 2015-05-15T00:47:55Z [Term] id: GO:1904217 name: regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate synonym: "regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of serine exchange enzyme" BROAD [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity relationship: regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity created_by: rl creation_date: 2015-05-15T08:18:23Z [Term] id: GO:1904218 name: negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate synonym: "down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylserine synthase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PS synthase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of PS synthase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity relationship: negatively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity created_by: rl creation_date: 2015-05-15T08:18:29Z [Term] id: GO:1904219 name: positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate synonym: "activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylserine synthase activity" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of PS synthase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of PS synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of PS synthase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity relationship: positively_regulates GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity created_by: rl creation_date: 2015-05-15T08:18:35Z [Term] id: GO:1904220 name: regulation of serine C-palmitoyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability synonym: "regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "regulation of serine palmitoyltransferase" BROAD [GOC:TermGenie] synonym: "regulation of SPT" RELATED [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004758 ! serine C-palmitoyltransferase activity relationship: regulates GO:0004758 ! serine C-palmitoyltransferase activity created_by: rl creation_date: 2015-05-15T08:27:33Z [Term] id: GO:1904221 name: negative regulation of serine C-palmitoyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability synonym: "down regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "down regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of SPT" RELATED [GOC:TermGenie] synonym: "down-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "down-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of SPT" RELATED [GOC:TermGenie] synonym: "downregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "downregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of SPT" RELATED [GOC:TermGenie] synonym: "inhibition of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie] synonym: "inhibition of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of SPT" RELATED [GOC:TermGenie] synonym: "negative regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "negative regulation of SPT" RELATED [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004758 ! serine C-palmitoyltransferase activity relationship: negatively_regulates GO:0004758 ! serine C-palmitoyltransferase activity created_by: rl creation_date: 2015-05-15T08:27:39Z [Term] id: GO:1904222 name: positive regulation of serine C-palmitoyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability synonym: "activation of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie] synonym: "activation of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of SPT" RELATED [GOC:TermGenie] synonym: "positive regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of SPT" RELATED [GOC:TermGenie] synonym: "up regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "up regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of SPT" RELATED [GOC:TermGenie] synonym: "up-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of SPT" RELATED [GOC:TermGenie] synonym: "upregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] synonym: "upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] synonym: "upregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of SPT" RELATED [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004758 ! serine C-palmitoyltransferase activity relationship: positively_regulates GO:0004758 ! serine C-palmitoyltransferase activity created_by: rl creation_date: 2015-05-15T08:27:45Z [Term] id: GO:1904223 name: regulation of glucuronosyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species synonym: "regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of GT activity" EXACT [GOC:TermGenie] synonym: "regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015020 ! glucuronosyltransferase activity relationship: regulates GO:0015020 ! glucuronosyltransferase activity created_by: rl creation_date: 2015-05-15T08:44:20Z [Term] id: GO:1904224 name: negative regulation of glucuronosyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species synonym: "down regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "down regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "down regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of GT activity" EXACT [GOC:TermGenie] synonym: "down regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "down regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "down regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "down regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "down-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of GT activity" EXACT [GOC:TermGenie] synonym: "down-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "down-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "down-regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "down-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "downregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "downregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of GT activity" EXACT [GOC:TermGenie] synonym: "downregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "downregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "downregulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "downregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of GT activity" NARROW [GOC:TermGenie] synonym: "inhibition of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "inhibition of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie] synonym: "inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDPGA transferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "inhibition of UDPGT activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of GT activity" EXACT [GOC:TermGenie] synonym: "negative regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "negative regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "negative regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "negative regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904223 ! regulation of glucuronosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015020 ! glucuronosyltransferase activity relationship: negatively_regulates GO:0015020 ! glucuronosyltransferase activity created_by: rl creation_date: 2015-05-15T08:44:26Z [Term] id: GO:1904225 name: positive regulation of glucuronosyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species synonym: "activation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of GT activity" NARROW [GOC:TermGenie] synonym: "activation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "activation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie] synonym: "activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDPGA transferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "activation of UDPGT activity" NARROW [GOC:TermGenie] synonym: "activation of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of GT activity" EXACT [GOC:TermGenie] synonym: "positive regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "positive regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "positive regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "positive regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "up regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "up regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of GT activity" EXACT [GOC:TermGenie] synonym: "up regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "up regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "up regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "up regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "up-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of GT activity" EXACT [GOC:TermGenie] synonym: "up-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "up-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "up-regulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "up-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] synonym: "upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] synonym: "upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] synonym: "upregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] synonym: "upregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of GT activity" EXACT [GOC:TermGenie] synonym: "upregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of PNP-UDPGT" RELATED [GOC:TermGenie] synonym: "upregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] synonym: "upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDPGA transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] synonym: "upregulation of UDPGT activity" EXACT [GOC:TermGenie] synonym: "upregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904223 ! regulation of glucuronosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015020 ! glucuronosyltransferase activity relationship: positively_regulates GO:0015020 ! glucuronosyltransferase activity created_by: rl creation_date: 2015-05-15T08:44:32Z [Term] id: GO:1904226 name: regulation of glycogen synthase activity, transferring glucose-1-phosphate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate relationship: regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate created_by: rl creation_date: 2015-05-15T09:23:08Z [Term] id: GO:1904227 name: negative regulation of glycogen synthase activity, transferring glucose-1-phosphate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] synonym: "down regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] synonym: "down-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] synonym: "downregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] synonym: "inhibition of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate relationship: negatively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate created_by: rl creation_date: 2015-05-15T09:23:14Z [Term] id: GO:1904228 name: positive regulation of glycogen synthase activity, transferring glucose-1-phosphate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] synonym: "activation of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie] synonym: "up regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] synonym: "up-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] synonym: "upregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate relationship: positively_regulates GO:0061547 ! glycogen synthase activity, transferring glucose-1-phosphate created_by: rl creation_date: 2015-05-15T09:23:20Z [Term] id: GO:1904229 name: regulation of succinate dehydrogenase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinic dehydrogenase activity" BROAD [GOC:TermGenie] synonym: "regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000104 ! succinate dehydrogenase activity relationship: regulates GO:0000104 ! succinate dehydrogenase activity created_by: rl creation_date: 2015-05-15T09:51:08Z [Term] id: GO:1904230 name: negative regulation of succinate dehydrogenase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "down regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "downregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "inhibition of fumarate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of fumarate reductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of fumaric hydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinate oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinodehydrogenase activity" NARROW [GOC:TermGenie] synonym: "inhibition of succinyl dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1904229 ! regulation of succinate dehydrogenase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000104 ! succinate dehydrogenase activity relationship: negatively_regulates GO:0000104 ! succinate dehydrogenase activity created_by: rl creation_date: 2015-05-15T09:51:14Z [Term] id: GO:1904231 name: positive regulation of succinate dehydrogenase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "activation of fumarate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of fumarate reductase activity" NARROW [GOC:TermGenie] synonym: "activation of fumaric hydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of succinate dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of succinate oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] synonym: "activation of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of succinodehydrogenase activity" NARROW [GOC:TermGenie] synonym: "activation of succinyl dehydrogenase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of fumarate reductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] synonym: "upregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1904229 ! regulation of succinate dehydrogenase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000104 ! succinate dehydrogenase activity relationship: positively_regulates GO:0000104 ! succinate dehydrogenase activity created_by: rl creation_date: 2015-05-15T09:51:20Z [Term] id: GO:1904232 name: regulation of aconitate hydratase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "regulation of citrate hydro-lyase activity" BROAD [GOC:TermGenie] synonym: "regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] is_a: GO:0051339 ! regulation of lyase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003994 ! aconitate hydratase activity relationship: regulates GO:0003994 ! aconitate hydratase activity created_by: rl creation_date: 2015-05-15T09:55:17Z [Term] id: GO:1904233 name: negative regulation of aconitate hydratase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "down regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "down regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "downregulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "downregulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "inhibition of aconitase activity" NARROW [GOC:TermGenie] synonym: "inhibition of aconitate hydratase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cis-aconitase activity" NARROW [GOC:TermGenie] synonym: "inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] is_a: GO:0051350 ! negative regulation of lyase activity is_a: GO:1904232 ! regulation of aconitate hydratase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003994 ! aconitate hydratase activity relationship: negatively_regulates GO:0003994 ! aconitate hydratase activity created_by: rl creation_date: 2015-05-15T09:55:23Z [Term] id: GO:1904234 name: positive regulation of aconitate hydratase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] synonym: "activation of aconitase activity" NARROW [GOC:TermGenie] synonym: "activation of aconitate hydratase activity" NARROW [GOC:TermGenie] synonym: "activation of cis-aconitase activity" NARROW [GOC:TermGenie] synonym: "activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie] synonym: "activation of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "up regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "up regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] synonym: "upregulation of aconitase activity" EXACT [GOC:TermGenie] synonym: "upregulation of aconitate hydratase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cis-aconitase activity" EXACT [GOC:TermGenie] synonym: "upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] is_a: GO:0051349 ! positive regulation of lyase activity is_a: GO:1904232 ! regulation of aconitate hydratase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003994 ! aconitate hydratase activity relationship: positively_regulates GO:0003994 ! aconitate hydratase activity created_by: rl creation_date: 2015-05-15T09:55:29Z [Term] id: GO:1904235 name: regulation of substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] synonym: "regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] is_a: GO:0010810 ! regulation of cell-substrate adhesion is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate relationship: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate created_by: pga creation_date: 2015-05-15T13:29:59Z [Term] id: GO:1904236 name: negative regulation of substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] synonym: "down regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "down regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "down-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "down-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "downregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "downregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "inhibition of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] synonym: "inhibition of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] synonym: "negative regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] is_a: GO:0010812 ! negative regulation of cell-substrate adhesion is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate relationship: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate created_by: pga creation_date: 2015-05-15T13:30:05Z [Term] id: GO:1904237 name: positive regulation of substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] synonym: "activation of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] synonym: "activation of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] synonym: "positive regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "up regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "up regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "up-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "up-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "upregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] synonym: "upregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] is_a: GO:0010811 ! positive regulation of cell-substrate adhesion is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate relationship: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate created_by: pga creation_date: 2015-05-15T13:30:11Z [Term] id: GO:1904238 name: pericyte cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830] is_a: GO:0030154 ! cell differentiation created_by: dph creation_date: 2015-05-15T14:50:13Z [Term] id: GO:1904239 name: regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly relationship: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly created_by: bf creation_date: 2015-05-18T09:50:21Z [Term] id: GO:1904240 name: negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "down regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "down-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "downregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly relationship: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly created_by: bf creation_date: 2015-05-18T09:50:27Z [Term] id: GO:1904241 name: positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "activation of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie] synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "up regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "up-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] synonym: "upregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly relationship: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly created_by: bf creation_date: 2015-05-18T09:50:34Z [Term] id: GO:1904242 name: regulation of pancreatic trypsinogen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] synonym: "regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0090186 ! regulation of pancreatic juice secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990747 ! pancreatic trypsinogen secretion relationship: regulates GO:1990747 ! pancreatic trypsinogen secretion created_by: sl creation_date: 2015-05-18T19:49:20Z [Term] id: GO:1904243 name: negative regulation of pancreatic trypsinogen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] synonym: "down regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "down regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] synonym: "inhibition of pancreatic trypsinogen release" NARROW [GOC:TermGenie] synonym: "inhibition of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090188 ! negative regulation of pancreatic juice secretion is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion relationship: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion created_by: sl creation_date: 2015-05-18T19:49:27Z [Term] id: GO:1904244 name: positive regulation of pancreatic trypsinogen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] synonym: "activation of pancreatic trypsinogen release" NARROW [GOC:TermGenie] synonym: "activation of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090187 ! positive regulation of pancreatic juice secretion is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion relationship: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion created_by: sl creation_date: 2015-05-18T19:49:32Z [Term] id: GO:1904245 name: regulation of polynucleotide adenylyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] synonym: "regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004652 ! polynucleotide adenylyltransferase activity relationship: regulates GO:0004652 ! polynucleotide adenylyltransferase activity created_by: kmv creation_date: 2015-05-19T14:47:20Z [Term] id: GO:1904246 name: negative regulation of polynucleotide adenylyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] synonym: "down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "down regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "down regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "down-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "downregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "downregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of NTP polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of poly(A) hydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of poly(A) polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of poly(A) synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of poly-A polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polyadenylate polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polyadenylate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polyadenylic polymerase activity" NARROW [GOC:TermGenie] synonym: "inhibition of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of RNA adenylating enzyme activity" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "inhibition of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "negative regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity relationship: negatively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity created_by: kmv creation_date: 2015-05-19T14:47:26Z [Term] id: GO:1904247 name: positive regulation of polynucleotide adenylyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] synonym: "activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of NTP polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of poly(A) hydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of poly(A) polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of poly(A) synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of poly-A polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of polyadenylate polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of polyadenylate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of polyadenylic polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of RNA adenylating enzyme activity" NARROW [GOC:TermGenie] synonym: "activation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "activation of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "positive regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "up regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "up-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of NTP polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of poly-A polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] synonym: "upregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity relationship: positively_regulates GO:0004652 ! polynucleotide adenylyltransferase activity created_by: kmv creation_date: 2015-05-19T14:47:32Z [Term] id: GO:1904248 name: regulation of age-related resistance namespace: biological_process def: "Any process that modulates the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] synonym: "regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "regulation of ARR" EXACT [GOC:TermGenie] synonym: "regulation of developmental resistance" BROAD [GOC:TermGenie] synonym: "regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "regulation of ontogenic resistance" BROAD [GOC:TermGenie] synonym: "regulation of senescence-induced resistance" NARROW [GOC:TermGenie] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090644 ! age-related resistance relationship: regulates GO:0090644 ! age-related resistance created_by: tb creation_date: 2015-05-19T20:19:58Z [Term] id: GO:1904249 name: negative regulation of age-related resistance namespace: biological_process def: "Any process that stops, prevents or reduces the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] synonym: "down regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "down regulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "down regulation of ARR" EXACT [GOC:TermGenie] synonym: "down regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "down regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "down regulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "down-regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "down-regulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "down-regulation of ARR" EXACT [GOC:TermGenie] synonym: "down-regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "down-regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "down-regulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "downregulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "downregulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "downregulation of ARR" EXACT [GOC:TermGenie] synonym: "downregulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "downregulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "downregulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "inhibition of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "inhibition of age-related resistance" NARROW [GOC:TermGenie] synonym: "inhibition of ARR" NARROW [GOC:TermGenie] synonym: "inhibition of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "inhibition of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "inhibition of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "negative regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "negative regulation of ARR" EXACT [GOC:TermGenie] synonym: "negative regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "negative regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "negative regulation of senescence-induced resistance" NARROW [GOC:TermGenie] is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904248 ! regulation of age-related resistance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090644 ! age-related resistance relationship: negatively_regulates GO:0090644 ! age-related resistance created_by: tb creation_date: 2015-05-19T20:20:05Z [Term] id: GO:1904250 name: positive regulation of age-related resistance namespace: biological_process def: "Any process that activates or increases the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] synonym: "activation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "activation of age-related resistance" NARROW [GOC:TermGenie] synonym: "activation of ARR" NARROW [GOC:TermGenie] synonym: "activation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "activation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "activation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "positive regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "positive regulation of ARR" EXACT [GOC:TermGenie] synonym: "positive regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "positive regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "positive regulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "up regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "up regulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "up regulation of ARR" EXACT [GOC:TermGenie] synonym: "up regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "up regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "up regulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "up-regulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "up-regulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "up-regulation of ARR" EXACT [GOC:TermGenie] synonym: "up-regulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "up-regulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "up-regulation of senescence-induced resistance" NARROW [GOC:TermGenie] synonym: "upregulation of adult seedling resistance" NARROW [GOC:TermGenie] synonym: "upregulation of age-related resistance" EXACT [GOC:TermGenie] synonym: "upregulation of ARR" EXACT [GOC:TermGenie] synonym: "upregulation of flowering-induced resistance" NARROW [GOC:TermGenie] synonym: "upregulation of mature seedling resistance" NARROW [GOC:TermGenie] synonym: "upregulation of senescence-induced resistance" NARROW [GOC:TermGenie] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904248 ! regulation of age-related resistance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090644 ! age-related resistance relationship: positively_regulates GO:0090644 ! age-related resistance created_by: tb creation_date: 2015-05-19T20:20:11Z [Term] id: GO:1904251 name: regulation of bile acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008206 ! bile acid metabolic process relationship: regulates GO:0008206 ! bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:28Z [Term] id: GO:1904252 name: negative regulation of bile acid metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008206 ! bile acid metabolic process relationship: negatively_regulates GO:0008206 ! bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:35Z [Term] id: GO:1904253 name: positive regulation of bile acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie] synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1904251 ! regulation of bile acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008206 ! bile acid metabolic process relationship: positively_regulates GO:0008206 ! bile acid metabolic process created_by: bf creation_date: 2015-05-20T11:04:40Z [Term] id: GO:1904254 name: regulation of iron ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "regulation of iron channel activity" EXACT [] synonym: "regulation of iron-specific channel activity" EXACT [GOC:TermGenie] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034759 ! regulation of iron ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005381 ! iron ion transmembrane transporter activity relationship: regulates GO:0005381 ! iron ion transmembrane transporter activity created_by: kom creation_date: 2015-05-20T14:05:00Z [Term] id: GO:1904255 name: negative regulation of iron ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "down regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of iron cation channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of iron channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of iron-specific channel activity" NARROW [GOC:TermGenie] synonym: "negative regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of iron channel activity" EXACT [] synonym: "negative regulation of iron-specific channel activity" EXACT [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity relationship: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity created_by: kom creation_date: 2015-05-20T14:05:06Z [Term] id: GO:1904256 name: positive regulation of iron ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] synonym: "activation of iron cation channel activity" NARROW [GOC:TermGenie] synonym: "activation of iron channel activity" NARROW [GOC:TermGenie] synonym: "activation of iron-specific channel activity" NARROW [GOC:TermGenie] synonym: "positive regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of iron channel activity" EXACT [] synonym: "positive regulation of iron transmembrane transporter activity" EXACT [] synonym: "positive regulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of iron cation channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of iron channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of iron-specific channel activity" EXACT [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005381 ! iron ion transmembrane transporter activity relationship: positively_regulates GO:0005381 ! iron ion transmembrane transporter activity created_by: kom creation_date: 2015-05-20T14:05:12Z [Term] id: GO:1904257 name: zinc ion import into Golgi apparatus namespace: biological_process def: "The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi apparatus." [GO_REF:0000075, GOC:TermGenie, PMID:25732056] synonym: "zinc II ion import across Golgi membrane" EXACT [] synonym: "zinc ion import across Golgi membrane" EXACT [] synonym: "zinc ion import into Golgi membrane" RELATED [] synonym: "zinc(2+) import across Golgi membrane" EXACT [] is_a: GO:0062111 ! zinc ion import into organelle created_by: tb creation_date: 2015-05-20T19:56:18Z [Term] id: GO:1904258 name: nuclear dicing body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body." [GO_REF:0000079, GOC:TermGenie, PMID:25902521] synonym: "D body assembly" EXACT [GOC:TermGenie] synonym: "D body formation" EXACT [GOC:TermGenie] synonym: "nuclear dicing body formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030575 ! nuclear body organization created_by: lr creation_date: 2015-05-20T20:48:07Z [Term] id: GO:1904259 name: regulation of basement membrane assembly involved in embryonic body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0110011 ! regulation of basement membrane organization is_a: GO:1901201 ! regulation of extracellular matrix assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis relationship: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis created_by: als creation_date: 2015-05-21T09:20:43Z [Term] id: GO:1904260 name: negative regulation of basement membrane assembly involved in embryonic body morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] synonym: "down regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1901202 ! negative regulation of extracellular matrix assembly is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis relationship: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis created_by: als creation_date: 2015-05-21T09:20:49Z [Term] id: GO:1904261 name: positive regulation of basement membrane assembly involved in embryonic body morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] synonym: "activation of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:1901203 ! positive regulation of extracellular matrix assembly is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis relationship: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis created_by: als creation_date: 2015-05-21T09:20:55Z [Term] id: GO:1904262 name: negative regulation of TORC1 signaling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275] synonym: "down regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of TORC1 signaling" EXACT [GOC:TermGenie] synonym: "down-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of TORC1 signaling" EXACT [GOC:TermGenie] synonym: "downregulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of TORC1 signaling" EXACT [GOC:TermGenie] synonym: "inhibition of TORC1 signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of TORC1 signaling" NARROW [GOC:TermGenie] synonym: "negative regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] is_a: GO:0032007 ! negative regulation of TOR signaling is_a: GO:1903432 ! regulation of TORC1 signaling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038202 ! TORC1 signaling relationship: negatively_regulates GO:0038202 ! TORC1 signaling created_by: lb creation_date: 2015-05-27T13:13:04Z [Term] id: GO:1904263 name: positive regulation of TORC1 signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275] synonym: "activation of TORC1 signal transduction" NARROW [GOC:TermGenie] synonym: "activation of TORC1 signaling" NARROW [GOC:TermGenie] synonym: "positive regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of TORC1 signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of TORC1 signaling" EXACT [GOC:TermGenie] synonym: "upregulation of TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of TORC1 signaling" EXACT [GOC:TermGenie] is_a: GO:0032008 ! positive regulation of TOR signaling is_a: GO:1903432 ! regulation of TORC1 signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038202 ! TORC1 signaling relationship: positively_regulates GO:0038202 ! TORC1 signaling created_by: lb creation_date: 2015-05-27T13:13:10Z [Term] id: GO:1904266 name: regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1900147 ! regulation of Schwann cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990751 ! Schwann cell chemotaxis relationship: regulates GO:1990751 ! Schwann cell chemotaxis created_by: sl creation_date: 2015-05-28T17:47:41Z [Term] id: GO:1904267 name: negative regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1900148 ! negative regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990751 ! Schwann cell chemotaxis relationship: negatively_regulates GO:1990751 ! Schwann cell chemotaxis created_by: sl creation_date: 2015-05-28T17:47:48Z [Term] id: GO:1904268 name: positive regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1900149 ! positive regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990751 ! Schwann cell chemotaxis relationship: positively_regulates GO:1990751 ! Schwann cell chemotaxis created_by: sl creation_date: 2015-05-28T17:47:55Z [Term] id: GO:1904269 name: cell leading edge cell cortex namespace: cellular_component def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030] synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie] synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie] synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie] synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie] synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie] synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0031252 ! cell leading edge relationship: part_of GO:0031252 ! cell leading edge created_by: kmv creation_date: 2015-05-28T19:16:03Z [Term] id: GO:1904270 name: pyroptosome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex." [GO_REF:0000079, GOC:TermGenie, PMID:17964261] synonym: "ASC pyroptosome assembly" EXACT [GOC:TermGenie] synonym: "ASC pyroptosome formation" EXACT [GOC:TermGenie] synonym: "pyroptosome complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: lb creation_date: 2015-05-29T08:25:45Z [Term] id: GO:1904271 name: L-proline import across plasma membrane namespace: biological_process alt_id: GO:1903809 def: "The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] synonym: "L-proline import into cell" EXACT [] is_a: GO:1904555 ! L-proline transmembrane transport is_a: GO:1905647 ! proline import across plasma membrane created_by: mah creation_date: 2015-01-16T14:36:01Z [Term] id: GO:1904272 name: L-tryptophan import across plasma membrane namespace: biological_process def: "The directed movement of L-tryptophan from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1904556 ! L-tryptophan transmembrane transport created_by: kmv creation_date: 2015-05-29T13:39:27Z [Term] id: GO:1904273 name: L-alanine import across plasma membrane namespace: biological_process def: "The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1904557 ! L-alanine transmembrane transport [Term] id: GO:1904274 name: tricellular tight junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962] synonym: "tricellular tight junction formation" EXACT [GOC:TermGenie] is_a: GO:0120192 ! tight junction assembly created_by: mr creation_date: 2015-05-29T16:31:00Z [Term] id: GO:1904275 name: tricellular tight junction disassembly namespace: biological_process def: "The disaggregation of a tricellular tight junction into its constituent components." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962] is_a: GO:1905071 ! tight junction disassembly created_by: mr creation_date: 2015-05-29T16:31:06Z [Term] id: GO:1904276 name: regulation of wax biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] synonym: "regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of wax formation" EXACT [GOC:TermGenie] synonym: "regulation of wax synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010025 ! wax biosynthetic process relationship: regulates GO:0010025 ! wax biosynthetic process created_by: tb creation_date: 2015-06-03T17:20:06Z [Term] id: GO:1904277 name: negative regulation of wax biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] synonym: "down regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of wax formation" EXACT [GOC:TermGenie] synonym: "down regulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of wax formation" EXACT [GOC:TermGenie] synonym: "down-regulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of wax formation" EXACT [GOC:TermGenie] synonym: "downregulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of wax anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of wax biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of wax biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of wax formation" NARROW [GOC:TermGenie] synonym: "inhibition of wax synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of wax formation" EXACT [GOC:TermGenie] synonym: "negative regulation of wax synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1904276 ! regulation of wax biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010025 ! wax biosynthetic process relationship: negatively_regulates GO:0010025 ! wax biosynthetic process created_by: tb creation_date: 2015-06-03T17:20:13Z [Term] id: GO:1904278 name: positive regulation of wax biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] synonym: "activation of wax anabolism" NARROW [GOC:TermGenie] synonym: "activation of wax biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of wax biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of wax formation" NARROW [GOC:TermGenie] synonym: "activation of wax synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of wax formation" EXACT [GOC:TermGenie] synonym: "positive regulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of wax formation" EXACT [GOC:TermGenie] synonym: "up regulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of wax formation" EXACT [GOC:TermGenie] synonym: "up-regulation of wax synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of wax anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of wax biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of wax biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of wax formation" EXACT [GOC:TermGenie] synonym: "upregulation of wax synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1904276 ! regulation of wax biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010025 ! wax biosynthetic process relationship: positively_regulates GO:0010025 ! wax biosynthetic process created_by: tb creation_date: 2015-06-03T17:20:19Z [Term] id: GO:1904279 name: regulation of transcription by RNA polymerase V namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] synonym: "regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "regulation of transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001060 ! transcription by RNA polymerase V relationship: regulates GO:0001060 ! transcription by RNA polymerase V created_by: tb creation_date: 2015-06-03T22:01:47Z [Term] id: GO:1904280 name: negative regulation of transcription by RNA polymerase V namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] synonym: "down regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "down regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "downregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] synonym: "inhibition of transcription from RNA pol V promoter" NARROW [GOC:TermGenie] synonym: "inhibition of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:1904279 ! regulation of transcription by RNA polymerase V intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001060 ! transcription by RNA polymerase V relationship: negatively_regulates GO:0001060 ! transcription by RNA polymerase V created_by: tb creation_date: 2015-06-03T22:01:54Z [Term] id: GO:1904281 name: positive regulation of transcription by RNA polymerase V namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] synonym: "activation of transcription from RNA pol V promoter" NARROW [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase V promoter" EXACT [] synonym: "up regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1904279 ! regulation of transcription by RNA polymerase V intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001060 ! transcription by RNA polymerase V relationship: positively_regulates GO:0001060 ! transcription by RNA polymerase V created_by: tb creation_date: 2015-06-03T22:02:00Z [Term] id: GO:1904282 name: regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] synonym: "regulation of antigen presentation, endogenous peptide antigen" BROAD [GOC:TermGenie] synonym: "regulation of antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [GOC:TermGenie] synonym: "regulation of antigen processing, endogenous antigen via MHC class I" BROAD [GOC:TermGenie] synonym: "regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I relationship: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I created_by: rl creation_date: 2015-06-04T12:05:28Z [Term] id: GO:1904283 name: negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] synonym: "down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "down regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "down-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "downregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie] synonym: "inhibition of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie] synonym: "negative regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I relationship: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I created_by: rl creation_date: 2015-06-04T12:05:34Z [Term] id: GO:1904284 name: positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] synonym: "activation of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie] synonym: "activation of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie] synonym: "positive regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "up regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "up-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] synonym: "upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] synonym: "upregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] is_a: GO:0002591 ! positive regulation of antigen processing and presentation of peptide antigen via MHC class I is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I relationship: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I created_by: rl creation_date: 2015-06-04T12:05:49Z [Term] id: GO:1904285 name: regulation of protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage relationship: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage created_by: mcc creation_date: 2015-06-05T17:21:14Z [Term] id: GO:1904286 name: negative regulation of protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] synonym: "down regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] synonym: "down-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] synonym: "downregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] synonym: "inhibition of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage relationship: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage created_by: mcc creation_date: 2015-06-05T17:21:21Z [Term] id: GO:1904287 name: positive regulation of protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] synonym: "activation of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie] synonym: "stimulation of protein-pyridoxal-5-phosphate linkage" EXACT [] synonym: "up regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] synonym: "up-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] synonym: "upregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage relationship: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage created_by: mcc creation_date: 2015-06-05T17:21:28Z [Term] id: GO:1904288 name: BAT3 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a BAT3 complex." [GO_REF:000102, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001] synonym: "Bag6 complex binding" EXACT [GOC:TermGenie] synonym: "BAG6-UBL4A-TRC35 complex binding" EXACT [GOC:TermGenie] synonym: "BAT3-TRC35-UBL4A complex binding" RELATED [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: bf creation_date: 2015-06-07T19:48:55Z [Term] id: GO:1904289 name: regulation of mitotic DNA damage checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:2000001 ! regulation of DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044773 ! mitotic DNA damage checkpoint relationship: regulates GO:0044773 ! mitotic DNA damage checkpoint created_by: kmv creation_date: 2015-06-09T13:03:11Z [Term] id: GO:1904290 name: negative regulation of mitotic DNA damage checkpoint namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] synonym: "down regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint is_a: GO:2000002 ! negative regulation of DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint relationship: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint created_by: kmv creation_date: 2015-06-09T13:03:17Z [Term] id: GO:1904291 name: positive regulation of mitotic DNA damage checkpoint namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] synonym: "activation of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint is_a: GO:2000003 ! positive regulation of DNA damage checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint relationship: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint created_by: kmv creation_date: 2015-06-09T13:03:23Z [Term] id: GO:1904292 name: regulation of ERAD pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036503 ! ERAD pathway relationship: regulates GO:0036503 ! ERAD pathway created_by: bf creation_date: 2015-06-09T14:44:27Z [Term] id: GO:1904293 name: negative regulation of ERAD pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560] synonym: "down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "down regulation of ERAD pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of ERAD pathway" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "downregulation of ERAD pathway" EXACT [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] synonym: "inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "inhibition of ERAD pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress is_a: GO:1904292 ! regulation of ERAD pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036503 ! ERAD pathway relationship: negatively_regulates GO:0036503 ! ERAD pathway created_by: bf creation_date: 2015-06-09T14:44:33Z [Term] id: GO:1904294 name: positive regulation of ERAD pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] synonym: "activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "activation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "activation of ERAD pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "up regulation of ERAD pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of ERAD pathway" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "upregulation of ERAD pathway" EXACT [GOC:TermGenie] is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process is_a: GO:1904292 ! regulation of ERAD pathway is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036503 ! ERAD pathway relationship: positively_regulates GO:0036503 ! ERAD pathway created_by: bf creation_date: 2015-06-09T14:44:39Z [Term] id: GO:1904295 name: regulation of osmolarity-sensing cation channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990760 ! osmolarity-sensing cation channel activity relationship: regulates GO:1990760 ! osmolarity-sensing cation channel activity created_by: sl creation_date: 2015-06-09T17:35:40Z [Term] id: GO:1904296 name: negative regulation of osmolarity-sensing cation channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] synonym: "down regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] synonym: "inhibition of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie] is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity is_a: GO:2000272 ! negative regulation of signaling receptor activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990760 ! osmolarity-sensing cation channel activity relationship: negatively_regulates GO:1990760 ! osmolarity-sensing cation channel activity created_by: sl creation_date: 2015-06-09T17:35:46Z [Term] id: GO:1904297 name: positive regulation of osmolarity-sensing cation channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] synonym: "activation of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie] synonym: "up regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity is_a: GO:2000273 ! positive regulation of signaling receptor activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990760 ! osmolarity-sensing cation channel activity relationship: positively_regulates GO:1990760 ! osmolarity-sensing cation channel activity created_by: sl creation_date: 2015-06-09T17:35:52Z [Term] id: GO:1904298 name: regulation of transcytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045056 ! transcytosis relationship: regulates GO:0045056 ! transcytosis created_by: sl creation_date: 2015-06-09T22:53:26Z [Term] id: GO:1904299 name: negative regulation of transcytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] synonym: "down regulation of transcytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of transcytosis" EXACT [GOC:TermGenie] synonym: "downregulation of transcytosis" EXACT [GOC:TermGenie] synonym: "inhibition of transcytosis" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1904298 ! regulation of transcytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045056 ! transcytosis relationship: negatively_regulates GO:0045056 ! transcytosis created_by: sl creation_date: 2015-06-09T22:53:32Z [Term] id: GO:1904300 name: positive regulation of transcytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] synonym: "activation of transcytosis" NARROW [GOC:TermGenie] synonym: "up regulation of transcytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of transcytosis" EXACT [GOC:TermGenie] synonym: "upregulation of transcytosis" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1904298 ! regulation of transcytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045056 ! transcytosis relationship: positively_regulates GO:0045056 ! transcytosis created_by: sl creation_date: 2015-06-09T22:53:38Z [Term] id: GO:1904301 name: regulation of maternal process involved in parturition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060137 ! maternal process involved in parturition relationship: regulates GO:0060137 ! maternal process involved in parturition created_by: sl creation_date: 2015-06-09T23:01:32Z [Term] id: GO:1904302 name: negative regulation of maternal process involved in parturition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] synonym: "down regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] synonym: "down-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] synonym: "downregulation of maternal process involved in parturition" EXACT [GOC:TermGenie] synonym: "inhibition of maternal process involved in parturition" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904301 ! regulation of maternal process involved in parturition is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060137 ! maternal process involved in parturition relationship: negatively_regulates GO:0060137 ! maternal process involved in parturition created_by: sl creation_date: 2015-06-09T23:01:38Z [Term] id: GO:1904303 name: positive regulation of maternal process involved in parturition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] synonym: "activation of maternal process involved in parturition" NARROW [GOC:TermGenie] synonym: "up regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] synonym: "up-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] synonym: "upregulation of maternal process involved in parturition" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904301 ! regulation of maternal process involved in parturition is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060137 ! maternal process involved in parturition relationship: positively_regulates GO:0060137 ! maternal process involved in parturition created_by: sl creation_date: 2015-06-09T23:01:45Z [Term] id: GO:1904304 name: regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] is_a: GO:0006940 ! regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction relationship: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:42Z [Term] id: GO:1904305 name: negative regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction relationship: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:48Z [Term] id: GO:1904306 name: positive regulation of gastro-intestinal system smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction relationship: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction created_by: sl creation_date: 2015-06-09T23:18:54Z [Term] id: GO:1904307 name: response to desipramine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0036276 ! response to antidepressant created_by: sl creation_date: 2015-06-10T17:00:31Z [Term] id: GO:1904308 name: cellular response to desipramine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904307 ! response to desipramine created_by: sl creation_date: 2015-06-10T17:00:37Z [Term] id: GO:1904309 name: response to cordycepin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-10T17:10:29Z [Term] id: GO:1904310 name: cellular response to cordycepin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904309 ! response to cordycepin created_by: sl creation_date: 2015-06-10T17:10:35Z [Term] id: GO:1904311 name: response to gold(3+) namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274] is_a: GO:0010035 ! response to inorganic substance created_by: sl creation_date: 2015-06-10T17:41:07Z [Term] id: GO:1904312 name: cellular response to gold(3+) namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904311 ! response to gold(3+) created_by: sl creation_date: 2015-06-10T17:41:13Z [Term] id: GO:1904313 name: response to methamphetamine hydrochloride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933] synonym: "response to methamphetamine HCL" EXACT [] is_a: GO:1902074 ! response to salt created_by: sl creation_date: 2015-06-10T17:47:09Z [Term] id: GO:1904314 name: cellular response to methamphetamine hydrochloride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933] synonym: "cellular response to methamphetamine HCL" EXACT [] is_a: GO:1902075 ! cellular response to salt is_a: GO:1904313 ! response to methamphetamine hydrochloride created_by: sl creation_date: 2015-06-10T17:47:15Z [Term] id: GO:1904315 name: transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227] subset: goslim_synapse synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie] synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie] is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential intersection_of: GO:0022824 ! transmitter-gated ion channel activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential created_by: dos creation_date: 2015-06-10T18:02:07Z [Term] id: GO:1904316 name: response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918] synonym: "response to PAF" EXACT [] synonym: "response to platelet-activating factor" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0033993 ! response to lipid is_a: GO:0042493 ! response to drug is_a: GO:0046683 ! response to organophosphorus is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-10T18:10:17Z [Term] id: GO:1904317 name: cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918] synonym: "cellular response to PAF" EXACT [] synonym: "cellular response to platelet-activating factor" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine created_by: sl creation_date: 2015-06-10T18:10:23Z [Term] id: GO:1904318 name: regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0044062 ! regulation of excretion is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060083 ! smooth muscle contraction involved in micturition relationship: regulates GO:0060083 ! smooth muscle contraction involved in micturition created_by: sl creation_date: 2015-06-10T18:46:11Z [Term] id: GO:1904319 name: negative regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0045986 ! negative regulation of smooth muscle contraction is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition relationship: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition created_by: sl creation_date: 2015-06-10T18:46:17Z [Term] id: GO:1904320 name: positive regulation of smooth muscle contraction involved in micturition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] is_a: GO:0045987 ! positive regulation of smooth muscle contraction is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition relationship: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition created_by: sl creation_date: 2015-06-10T18:46:23Z [Term] id: GO:1904321 name: response to forskolin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0046677 ! response to antibiotic is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-06-10T19:01:27Z [Term] id: GO:1904322 name: cellular response to forskolin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904321 ! response to forskolin created_by: sl creation_date: 2015-06-10T19:01:33Z [Term] id: GO:1904323 name: regulation of inhibitory G protein-coupled receptor phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] synonym: "regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation relationship: regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation created_by: sl creation_date: 2015-06-10T19:46:37Z [Term] id: GO:1904324 name: negative regulation of inhibitory G protein-coupled receptor phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] synonym: "down regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] synonym: "downregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] synonym: "inhibition of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie] synonym: "negative regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation relationship: negatively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation created_by: sl creation_date: 2015-06-10T19:46:43Z [Term] id: GO:1904325 name: positive regulation of inhibitory G protein-coupled receptor phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] synonym: "activation of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie] synonym: "positive regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] synonym: "up regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] synonym: "upregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation relationship: positively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation created_by: sl creation_date: 2015-06-10T19:46:50Z [Term] id: GO:1904326 name: negative regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness." [GO_REF:0000058, GOC:TermGenie, PMID:10923657] synonym: "down regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] synonym: "down-regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] synonym: "downregulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] synonym: "inhibition of circadian sleep/wake cycle, wakefulness" NARROW [GOC:TermGenie] is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness is_a: GO:0042754 ! negative regulation of circadian rhythm is_a: GO:0048521 ! negative regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness relationship: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness created_by: sl creation_date: 2015-06-10T20:18:45Z [Term] id: GO:1904327 name: protein localization to cytosolic proteasome complex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] synonym: "protein localisation in cytosolic proteasome complex" EXACT [GOC:TermGenie] synonym: "protein localisation to cytosolic proteasome complex" EXACT [GOC:TermGenie] synonym: "protein localization in cytosolic proteasome complex" EXACT [GOC:TermGenie] is_a: GO:0008104 ! protein localization created_by: bf creation_date: 2015-06-11T09:29:53Z [Term] id: GO:1904328 name: regulation of myofibroblast contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] synonym: "regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "regulation of MFB contraction" EXACT [GOC:TermGenie] is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990764 ! myofibroblast contraction relationship: regulates GO:1990764 ! myofibroblast contraction created_by: sl creation_date: 2015-06-11T15:30:29Z [Term] id: GO:1904329 name: negative regulation of myofibroblast contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] synonym: "down regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "down regulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "down regulation of myofibroblast contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast contraction" EXACT [GOC:TermGenie] synonym: "downregulation of MF contraction" EXACT [GOC:TermGenie] synonym: "downregulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast contraction" EXACT [GOC:TermGenie] synonym: "inhibition of MF contraction" NARROW [GOC:TermGenie] synonym: "inhibition of MFB contraction" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast contraction" NARROW [GOC:TermGenie] synonym: "negative regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "negative regulation of MFB contraction" EXACT [GOC:TermGenie] is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1904328 ! regulation of myofibroblast contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990764 ! myofibroblast contraction relationship: negatively_regulates GO:1990764 ! myofibroblast contraction created_by: sl creation_date: 2015-06-11T15:30:35Z [Term] id: GO:1904330 name: positive regulation of myofibroblast contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] synonym: "activation of MF contraction" NARROW [GOC:TermGenie] synonym: "activation of MFB contraction" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast contraction" NARROW [GOC:TermGenie] synonym: "positive regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "positive regulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "up regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "up regulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of MF contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast contraction" EXACT [GOC:TermGenie] synonym: "upregulation of MF contraction" EXACT [GOC:TermGenie] synonym: "upregulation of MFB contraction" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast contraction" EXACT [GOC:TermGenie] is_a: GO:1903116 ! positive regulation of actin filament-based movement is_a: GO:1904328 ! regulation of myofibroblast contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990764 ! myofibroblast contraction relationship: positively_regulates GO:1990764 ! myofibroblast contraction created_by: sl creation_date: 2015-06-11T15:30:41Z [Term] id: GO:1904331 name: regulation of error-prone translesion synthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] synonym: "regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "regulation of mutagenic PRR" EXACT [GOC:TermGenie] is_a: GO:0006282 ! regulation of DNA repair is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042276 ! error-prone translesion synthesis relationship: regulates GO:0042276 ! error-prone translesion synthesis created_by: kmv creation_date: 2015-06-11T16:24:47Z [Term] id: GO:1904332 name: negative regulation of error-prone translesion synthesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] synonym: "down regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "down regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "down regulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "down-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "down-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "down-regulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "downregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "downregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "downregulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "inhibition of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "inhibition of error-prone translesion synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "inhibition of mutagenic PRR" NARROW [GOC:TermGenie] synonym: "negative regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "negative regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "negative regulation of mutagenic PRR" EXACT [GOC:TermGenie] is_a: GO:0045738 ! negative regulation of DNA repair is_a: GO:1904331 ! regulation of error-prone translesion synthesis is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042276 ! error-prone translesion synthesis relationship: negatively_regulates GO:0042276 ! error-prone translesion synthesis created_by: kmv creation_date: 2015-06-11T16:24:53Z [Term] id: GO:1904333 name: positive regulation of error-prone translesion synthesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] synonym: "activation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "activation of error-prone translesion synthesis" NARROW [GOC:TermGenie] synonym: "activation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "activation of mutagenic PRR" NARROW [GOC:TermGenie] synonym: "positive regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "positive regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "positive regulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "up regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "up regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "up regulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "up-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "up-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "up-regulation of mutagenic PRR" EXACT [GOC:TermGenie] synonym: "upregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "upregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] synonym: "upregulation of mutagenic PRR" EXACT [GOC:TermGenie] is_a: GO:0045739 ! positive regulation of DNA repair is_a: GO:1904331 ! regulation of error-prone translesion synthesis is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042276 ! error-prone translesion synthesis relationship: positively_regulates GO:0042276 ! error-prone translesion synthesis created_by: kmv creation_date: 2015-06-11T16:25:10Z [Term] id: GO:1904334 name: heme import across plasma membrane namespace: biological_process def: "The directed movement of heme from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:25733668] is_a: GO:0033212 ! iron import into cell is_a: GO:0035351 ! heme transmembrane transport is_a: GO:0098739 ! import across plasma membrane created_by: al creation_date: 2015-06-11T16:56:21Z [Term] id: GO:1904335 name: regulation of ductus arteriosus closure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097070 ! ductus arteriosus closure relationship: regulates GO:0097070 ! ductus arteriosus closure created_by: sl creation_date: 2015-06-11T17:45:15Z [Term] id: GO:1904336 name: negative regulation of ductus arteriosus closure namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] synonym: "down regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] synonym: "down-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] synonym: "downregulation of ductus arteriosus closure" EXACT [GOC:TermGenie] synonym: "inhibition of ductus arteriosus closure" NARROW [GOC:TermGenie] is_a: GO:1904335 ! regulation of ductus arteriosus closure is_a: GO:1905652 ! negative regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097070 ! ductus arteriosus closure relationship: negatively_regulates GO:0097070 ! ductus arteriosus closure created_by: sl creation_date: 2015-06-11T17:45:21Z [Term] id: GO:1904337 name: positive regulation of ductus arteriosus closure namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] synonym: "activation of ductus arteriosus closure" NARROW [GOC:TermGenie] synonym: "up regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] synonym: "up-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] synonym: "upregulation of ductus arteriosus closure" EXACT [GOC:TermGenie] is_a: GO:1904335 ! regulation of ductus arteriosus closure is_a: GO:1905653 ! positive regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097070 ! ductus arteriosus closure relationship: positively_regulates GO:0097070 ! ductus arteriosus closure created_by: sl creation_date: 2015-06-11T17:45:27Z [Term] id: GO:1904338 name: regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071542 ! dopaminergic neuron differentiation relationship: regulates GO:0071542 ! dopaminergic neuron differentiation created_by: sl creation_date: 2015-06-11T18:06:19Z [Term] id: GO:1904339 name: negative regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation relationship: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation created_by: sl creation_date: 2015-06-11T18:06:25Z [Term] id: GO:1904340 name: positive regulation of dopaminergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071542 ! dopaminergic neuron differentiation relationship: positively_regulates GO:0071542 ! dopaminergic neuron differentiation created_by: sl creation_date: 2015-06-11T18:06:32Z [Term] id: GO:1904341 name: regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990765 ! colon smooth muscle contraction relationship: regulates GO:1990765 ! colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:16:58Z [Term] id: GO:1904342 name: negative regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990765 ! colon smooth muscle contraction relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:17:05Z [Term] id: GO:1904343 name: positive regulation of colon smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904341 ! regulation of colon smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990765 ! colon smooth muscle contraction relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:17:11Z [Term] id: GO:1904344 name: regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990768 ! gastric mucosal blood circulation relationship: regulates GO:1990768 ! gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:31Z [Term] id: GO:1904345 name: negative regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903523 ! negative regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990768 ! gastric mucosal blood circulation relationship: negatively_regulates GO:1990768 ! gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:44Z [Term] id: GO:1904346 name: positive regulation of gastric mucosal blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie] synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] is_a: GO:1903524 ! positive regulation of blood circulation is_a: GO:1904344 ! regulation of gastric mucosal blood circulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990768 ! gastric mucosal blood circulation relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulation created_by: sl creation_date: 2015-06-11T21:20:50Z [Term] id: GO:1904347 name: regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990770 ! small intestine smooth muscle contraction relationship: regulates GO:1990770 ! small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:34Z [Term] id: GO:1904348 name: negative regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:40Z [Term] id: GO:1904349 name: positive regulation of small intestine smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990770 ! small intestine smooth muscle contraction relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T21:37:46Z [Term] id: GO:1904350 name: regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007039 ! protein catabolic process in the vacuole relationship: regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:36Z [Term] id: GO:1904351 name: negative regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:1903363 ! negative regulation of cellular protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:42Z [Term] id: GO:1904352 name: positive regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:1903364 ! positive regulation of cellular protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007039 ! protein catabolic process in the vacuole relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole created_by: rl creation_date: 2015-06-12T09:10:49Z [Term] id: GO:1904353 name: regulation of telomere capping namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] synonym: "regulation of telomere end protection" EXACT [GOC:TermGenie] is_a: GO:0032204 ! regulation of telomere maintenance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016233 ! telomere capping relationship: regulates GO:0016233 ! telomere capping created_by: nc creation_date: 2015-06-12T16:51:08Z [Term] id: GO:1904354 name: negative regulation of telomere capping namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] synonym: "down regulation of telomere capping" EXACT [GOC:TermGenie] synonym: "down regulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere capping" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "downregulation of telomere capping" EXACT [GOC:TermGenie] synonym: "downregulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "inhibition of telomere capping" NARROW [GOC:TermGenie] synonym: "inhibition of telomere end protection" NARROW [GOC:TermGenie] synonym: "negative regulation of telomere end protection" EXACT [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904353 ! regulation of telomere capping intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016233 ! telomere capping relationship: negatively_regulates GO:0016233 ! telomere capping created_by: nc creation_date: 2015-06-12T16:51:14Z [Term] id: GO:1904355 name: positive regulation of telomere capping namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] synonym: "activation of telomere capping" NARROW [GOC:TermGenie] synonym: "activation of telomere end protection" NARROW [GOC:TermGenie] synonym: "positive regulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "up regulation of telomere capping" EXACT [GOC:TermGenie] synonym: "up regulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "up-regulation of telomere capping" EXACT [GOC:TermGenie] synonym: "up-regulation of telomere end protection" EXACT [GOC:TermGenie] synonym: "upregulation of telomere capping" EXACT [GOC:TermGenie] synonym: "upregulation of telomere end protection" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:1904353 ! regulation of telomere capping intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016233 ! telomere capping relationship: positively_regulates GO:0016233 ! telomere capping created_by: nc creation_date: 2015-06-12T16:51:20Z [Term] id: GO:1904356 name: regulation of telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] is_a: GO:0032204 ! regulation of telomere maintenance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010833 ! telomere maintenance via telomere lengthening relationship: regulates GO:0010833 ! telomere maintenance via telomere lengthening created_by: nc creation_date: 2015-06-12T16:53:16Z [Term] id: GO:1904357 name: negative regulation of telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] synonym: "down regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] synonym: "downregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] synonym: "inhibition of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening relationship: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening created_by: nc creation_date: 2015-06-12T16:53:22Z [Term] id: GO:1904358 name: positive regulation of telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] synonym: "activation of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie] synonym: "up regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] synonym: "up-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] synonym: "upregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening relationship: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening created_by: nc creation_date: 2015-06-12T16:53:28Z [Term] id: GO:1904359 name: regulation of spore germination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009847 ! spore germination relationship: regulates GO:0009847 ! spore germination created_by: pf creation_date: 2015-06-12T19:46:06Z [Term] id: GO:1904360 name: negative regulation of spore germination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] synonym: "down regulation of spore germination" EXACT [GOC:TermGenie] synonym: "down-regulation of spore germination" EXACT [GOC:TermGenie] synonym: "downregulation of spore germination" EXACT [GOC:TermGenie] synonym: "inhibition of spore germination" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904359 ! regulation of spore germination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009847 ! spore germination relationship: negatively_regulates GO:0009847 ! spore germination created_by: pf creation_date: 2015-06-12T19:46:12Z [Term] id: GO:1904361 name: positive regulation of spore germination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] synonym: "activation of spore germination" NARROW [GOC:TermGenie] synonym: "up regulation of spore germination" EXACT [GOC:TermGenie] synonym: "up-regulation of spore germination" EXACT [GOC:TermGenie] synonym: "upregulation of spore germination" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904359 ! regulation of spore germination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009847 ! spore germination relationship: positively_regulates GO:0009847 ! spore germination created_by: pf creation_date: 2015-06-12T19:46:18Z [Term] id: GO:1904362 name: regulation of calcitonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] is_a: GO:0090276 ! regulation of peptide hormone secretion is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036161 ! calcitonin secretion relationship: regulates GO:0036161 ! calcitonin secretion created_by: sl creation_date: 2015-06-15T17:54:52Z [Term] id: GO:1904363 name: negative regulation of calcitonin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "down regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036161 ! calcitonin secretion relationship: negatively_regulates GO:0036161 ! calcitonin secretion created_by: sl creation_date: 2015-06-15T17:54:58Z [Term] id: GO:1904364 name: positive regulation of calcitonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "activation of calcitonin secretion" NARROW [GOC:TermGenie] synonym: "up regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036161 ! calcitonin secretion relationship: positively_regulates GO:0036161 ! calcitonin secretion created_by: sl creation_date: 2015-06-15T17:55:05Z [Term] id: GO:1904365 name: regulation of chemokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042466 ! chemokinesis relationship: regulates GO:0042466 ! chemokinesis created_by: sl creation_date: 2015-06-15T22:44:06Z [Term] id: GO:1904366 name: negative regulation of chemokinesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] synonym: "down regulation of chemokinesis" EXACT [GOC:TermGenie] synonym: "down-regulation of chemokinesis" EXACT [GOC:TermGenie] synonym: "downregulation of chemokinesis" EXACT [GOC:TermGenie] synonym: "inhibition of chemokinesis" NARROW [GOC:TermGenie] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:1904365 ! regulation of chemokinesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042466 ! chemokinesis relationship: negatively_regulates GO:0042466 ! chemokinesis created_by: sl creation_date: 2015-06-15T22:44:12Z [Term] id: GO:1904367 name: positive regulation of chemokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] synonym: "activation of chemokinesis" NARROW [GOC:TermGenie] synonym: "up regulation of chemokinesis" EXACT [GOC:TermGenie] synonym: "up-regulation of chemokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of chemokinesis" EXACT [GOC:TermGenie] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:1904365 ! regulation of chemokinesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042466 ! chemokinesis relationship: positively_regulates GO:0042466 ! chemokinesis created_by: sl creation_date: 2015-06-15T22:44:18Z [Term] id: GO:1904368 name: regulation of sclerenchyma cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014001 ! sclerenchyma cell differentiation relationship: regulates GO:0014001 ! sclerenchyma cell differentiation created_by: tb creation_date: 2015-06-17T19:53:00Z [Term] id: GO:1904369 name: positive regulation of sclerenchyma cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534] synonym: "up regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1904368 ! regulation of sclerenchyma cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014001 ! sclerenchyma cell differentiation relationship: positively_regulates GO:0014001 ! sclerenchyma cell differentiation created_by: tb creation_date: 2015-06-17T19:53:06Z [Term] id: GO:1904370 name: regulation of protein localization to actin cortical patch namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044379 ! protein localization to actin cortical patch relationship: regulates GO:0044379 ! protein localization to actin cortical patch created_by: sl creation_date: 2015-06-18T22:23:31Z [Term] id: GO:1904371 name: negative regulation of protein localization to actin cortical patch namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to actin cortical patch" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to actin cortical patch" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] is_a: GO:1904370 ! regulation of protein localization to actin cortical patch is_a: GO:1904777 ! negative regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044379 ! protein localization to actin cortical patch relationship: negatively_regulates GO:0044379 ! protein localization to actin cortical patch created_by: sl creation_date: 2015-06-18T22:23:37Z [Term] id: GO:1904372 name: positive regulation of protein localization to actin cortical patch namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localisation to actin cortical patch" NARROW [GOC:TermGenie] synonym: "activation of protein localization to actin cortical patch" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] is_a: GO:1904370 ! regulation of protein localization to actin cortical patch is_a: GO:1904778 ! positive regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044379 ! protein localization to actin cortical patch relationship: positively_regulates GO:0044379 ! protein localization to actin cortical patch created_by: sl creation_date: 2015-06-18T22:23:43Z [Term] id: GO:1904373 name: response to kainic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2015-06-18T22:42:52Z [Term] id: GO:1904374 name: cellular response to kainic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1904373 ! response to kainic acid created_by: sl creation_date: 2015-06-18T22:42:58Z [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990778 ! protein localization to cell periphery relationship: regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:25Z [Term] id: GO:1904376 name: negative regulation of protein localization to cell periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990778 ! protein localization to cell periphery relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:32Z [Term] id: GO:1904377 name: positive regulation of protein localization to cell periphery namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990778 ! protein localization to cell periphery relationship: positively_regulates GO:1990778 ! protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:37Z [Term] id: GO:1904378 name: maintenance of unfolded protein involved in ERAD pathway namespace: biological_process def: "Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303] synonym: "chaperone holdase activity" RELATED [PMID:23417671] synonym: "ERAD chaperone-like activity" RELATED [GOC:bf] synonym: "holdase activity" RELATED [PMID:21636303] synonym: "maintenance of unfolded protein during ERAD" RELATED [GOC:bf] synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "maintenance of unfolded protein involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] is_a: GO:0036506 ! maintenance of unfolded protein intersection_of: GO:0036506 ! maintenance of unfolded protein intersection_of: part_of GO:0036503 ! ERAD pathway relationship: part_of GO:0036503 ! ERAD pathway created_by: bf creation_date: 2015-06-23T09:21:53Z [Term] id: GO:1904379 name: protein localization to cytosolic proteasome complex involved in ERAD pathway namespace: biological_process def: "Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303] synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localisation in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localisation to cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localization in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] synonym: "protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] is_a: GO:1904327 ! protein localization to cytosolic proteasome complex intersection_of: GO:1904327 ! protein localization to cytosolic proteasome complex intersection_of: part_of GO:0036503 ! ERAD pathway relationship: part_of GO:0036503 ! ERAD pathway created_by: bf creation_date: 2015-06-23T09:30:07Z [Term] id: GO:1904380 name: endoplasmic reticulum mannose trimming namespace: biological_process def: "Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC)." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966] synonym: "ER mannose trimming" EXACT [GOC:bf] synonym: "ER protein alpha-1,2-demannosylation" EXACT [GOC:bf] synonym: "glycoprotein mannose trimming in endoplasmic reticulum quality control compartment" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming in ER quality control compartment" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming in ER-derived quality control compartment" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming in ERQC" RELATED [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation in ER" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation in ER quality control compartment" EXACT [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation in ER-derived quality control compartment" RELATED [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation in ERQC" EXACT [GOC:TermGenie] is_a: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: occurs_in GO:0044322 ! endoplasmic reticulum quality control compartment relationship: occurs_in GO:0044322 ! endoplasmic reticulum quality control compartment created_by: bf creation_date: 2015-06-23T09:35:41Z [Term] id: GO:1904381 name: Golgi apparatus mannose trimming namespace: biological_process def: "Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:10915796] synonym: "glycoprotein mannose trimming in Golgi apparatus" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming in Golgi complex" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming in Golgi ribbon" RELATED [GOC:TermGenie] synonym: "mannose trimming in cis-Golgi" NARROW [GOC:bf] synonym: "mannose trimming in Golgi" BROAD [GOC:TermGenie] synonym: "mannose trimming in Golgi apparatus" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation in Golgi apparatus" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation in Golgi complex" EXACT [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation in Golgi ribbon" NARROW [GOC:TermGenie] is_a: GO:0006491 ! N-glycan processing is_a: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: occurs_in GO:0005794 ! Golgi apparatus relationship: occurs_in GO:0005794 ! Golgi apparatus created_by: bf creation_date: 2015-06-23T09:42:06Z [Term] id: GO:1904382 name: mannose trimming involved in glycoprotein ERAD pathway namespace: biological_process def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966] synonym: "glycoprotein mannose trimming involved in ER-associated glycoprotein degradation" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD pathway" RELATED [GOC:TermGenie] synonym: "glycoprotein mannose trimming involved in gpERAD" RELATED [GOC:TermGenie] synonym: "mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation" EXACT [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD" EXACT [GOC:TermGenie] synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway" EXACT [GOC:bf] synonym: "protein alpha-1,2-demannosylation involved in gpERAD" EXACT [GOC:TermGenie] is_a: GO:0035977 ! protein deglycosylation involved in glycoprotein catabolic process is_a: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: GO:0036508 ! protein alpha-1,2-demannosylation intersection_of: part_of GO:0097466 ! ubiquitin-dependent glycoprotein ERAD pathway relationship: part_of GO:0097466 ! ubiquitin-dependent glycoprotein ERAD pathway created_by: bf creation_date: 2015-06-23T09:46:55Z [Term] id: GO:1904383 name: response to sodium phosphate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1902074 ! response to salt created_by: sl creation_date: 2015-06-23T16:55:07Z [Term] id: GO:1904384 name: cellular response to sodium phosphate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659] is_a: GO:1902075 ! cellular response to salt is_a: GO:1904383 ! response to sodium phosphate created_by: sl creation_date: 2015-06-23T16:55:13Z [Term] id: GO:1904385 name: cellular response to angiotensin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [GO_REF:0000071, GOC:TermGenie, PMID:22982863] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1990776 ! response to angiotensin created_by: sl creation_date: 2015-06-23T17:27:14Z [Term] id: GO:1904386 name: response to L-phenylalanine derivative namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407] is_a: GO:0010243 ! response to organonitrogen compound created_by: sl creation_date: 2015-06-23T17:56:19Z [Term] id: GO:1904387 name: cellular response to L-phenylalanine derivative namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904386 ! response to L-phenylalanine derivative created_by: sl creation_date: 2015-06-23T17:56:25Z [Term] id: GO:1904388 name: negative regulation of ncRNA transcription associated with protein coding gene TSS/TES namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES." [GO_REF:0000058, GOC:TermGenie, PMID:20502517] synonym: "down regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] synonym: "down regulation of pasRNA transcription" NARROW [GOC:TermGenie] synonym: "down-regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] synonym: "down-regulation of pasRNA transcription" NARROW [GOC:TermGenie] synonym: "downregulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] synonym: "downregulation of pasRNA transcription" NARROW [GOC:TermGenie] synonym: "inhibition of ncRNA transcription associated with protein coding gene TSS/TES" NARROW [GOC:TermGenie] synonym: "inhibition of pasRNA transcription" NARROW [GOC:TermGenie] synonym: "negative regulation of pasRNA transcription" NARROW [GOC:TermGenie] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098790 ! ncRNA transcription associated with protein coding gene TSS/TES relationship: negatively_regulates GO:0098790 ! ncRNA transcription associated with protein coding gene TSS/TES created_by: dos creation_date: 2015-06-23T18:11:39Z [Term] id: GO:1904389 name: rod bipolar cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:16914133] is_a: GO:0060040 ! retinal bipolar neuron differentiation created_by: sl creation_date: 2015-06-23T19:01:11Z [Term] id: GO:1904390 name: cone retinal bipolar cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:24123365] synonym: "cone bipolar cell differentiation" EXACT [PMID:14745032] synonym: "retinal cone bipolar cell differentiation" EXACT [] is_a: GO:0060040 ! retinal bipolar neuron differentiation created_by: sl creation_date: 2015-06-23T19:01:16Z [Term] id: GO:1904391 name: response to ciliary neurotrophic factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133] is_a: GO:0010243 ! response to organonitrogen compound created_by: sl creation_date: 2015-06-23T19:13:04Z [Term] id: GO:1904392 name: cellular response to ciliary neurotrophic factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904391 ! response to ciliary neurotrophic factor created_by: sl creation_date: 2015-06-23T19:13:10Z [Term] id: GO:1904393 name: regulation of skeletal muscle acetylcholine-gated channel clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1901626 ! regulation of postsynaptic membrane organization is_a: GO:1903909 ! regulation of receptor clustering is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering relationship: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering created_by: sl creation_date: 2015-06-23T19:23:25Z [Term] id: GO:1904394 name: negative regulation of skeletal muscle acetylcholine-gated channel clustering namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "down regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "down regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "down regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie] synonym: "inhibition of skeletal muscle AChR clustering" NARROW [GOC:TermGenie] synonym: "inhibition of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie] synonym: "negative regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization is_a: GO:1903910 ! negative regulation of receptor clustering is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering is_a: GO:1904397 ! negative regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering relationship: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering created_by: sl creation_date: 2015-06-23T19:23:31Z [Term] id: GO:1904395 name: positive regulation of skeletal muscle acetylcholine-gated channel clustering namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "activation of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie] synonym: "activation of skeletal muscle AChR clustering" NARROW [GOC:TermGenie] synonym: "activation of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie] synonym: "positive regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "up regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "up regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "up regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization is_a: GO:1903911 ! positive regulation of receptor clustering is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering is_a: GO:1904398 ! positive regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering relationship: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering created_by: sl creation_date: 2015-06-23T19:23:37Z [Term] id: GO:1904396 name: regulation of neuromuscular junction development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007528 ! neuromuscular junction development relationship: regulates GO:0007528 ! neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:42Z [Term] id: GO:1904397 name: negative regulation of neuromuscular junction development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:1904396 ! regulation of neuromuscular junction development is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007528 ! neuromuscular junction development relationship: negatively_regulates GO:0007528 ! neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:48Z [Term] id: GO:1904398 name: positive regulation of neuromuscular junction development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "activation of NMJ stability" RELATED [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007528 ! neuromuscular junction development relationship: positively_regulates GO:0007528 ! neuromuscular junction development created_by: sl creation_date: 2015-06-23T19:23:54Z [Term] id: GO:1904399 name: heparan sulfate binding namespace: molecular_function def: "Interacting selectively and non-covalently with heparan sulfate." [GO_REF:0000067, GOC:TermGenie, PMID:8567685] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding created_by: sl creation_date: 2015-06-23T19:56:54Z [Term] id: GO:1904400 name: response to Thyroid stimulating hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928] is_a: GO:1904587 ! response to glycoprotein created_by: sl creation_date: 2015-06-23T20:57:53Z [Term] id: GO:1904401 name: cellular response to Thyroid stimulating hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928] is_a: GO:1904400 ! response to Thyroid stimulating hormone is_a: GO:1904588 ! cellular response to glycoprotein created_by: sl creation_date: 2015-06-23T20:57:59Z [Term] id: GO:1904402 name: response to nocodazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-06-23T21:10:45Z [Term] id: GO:1904403 name: cellular response to nocodazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904402 ! response to nocodazole created_by: sl creation_date: 2015-06-23T21:10:52Z [Term] id: GO:1904404 name: response to formaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] is_a: GO:0010033 ! response to organic substance is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-23T21:14:04Z [Term] id: GO:1904405 name: cellular response to formaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1904404 ! response to formaldehyde created_by: sl creation_date: 2015-06-23T21:14:10Z [Term] id: GO:1904406 name: negative regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "down regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046209 ! nitric oxide metabolic process relationship: negatively_regulates GO:0046209 ! nitric oxide metabolic process created_by: sl creation_date: 2015-06-24T20:56:41Z [Term] id: GO:1904407 name: positive regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] synonym: "activation of nitric oxide metabolic process" NARROW [GOC:TermGenie] synonym: "activation of nitric oxide metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046209 ! nitric oxide metabolic process relationship: positively_regulates GO:0046209 ! nitric oxide metabolic process created_by: sl creation_date: 2015-06-24T20:56:47Z [Term] id: GO:1904408 name: melatonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923] is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding is_a: GO:0042562 ! hormone binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: mr creation_date: 2015-06-25T19:19:53Z [Term] id: GO:1904409 name: regulation of secretory granule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033363 ! secretory granule organization relationship: regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:42Z [Term] id: GO:1904410 name: negative regulation of secretory granule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033363 ! secretory granule organization relationship: negatively_regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:49Z [Term] id: GO:1904411 name: positive regulation of secretory granule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033363 ! secretory granule organization relationship: positively_regulates GO:0033363 ! secretory granule organization created_by: sl creation_date: 2015-06-25T19:40:55Z [Term] id: GO:1904412 name: regulation of cardiac ventricle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003231 ! cardiac ventricle development relationship: regulates GO:0003231 ! cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:15Z [Term] id: GO:1904413 name: negative regulation of cardiac ventricle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003231 ! cardiac ventricle development relationship: negatively_regulates GO:0003231 ! cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:21Z [Term] id: GO:1904414 name: positive regulation of cardiac ventricle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003231 ! cardiac ventricle development relationship: positively_regulates GO:0003231 ! cardiac ventricle development created_by: sl creation_date: 2015-06-25T19:52:27Z [Term] id: GO:1904415 name: regulation of xenophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098792 ! xenophagy relationship: regulates GO:0098792 ! xenophagy created_by: pad creation_date: 2015-06-29T12:30:47Z [Term] id: GO:1904416 name: negative regulation of xenophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). synonym: "down regulation of xenophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of xenophagy" EXACT [GOC:TermGenie] synonym: "downregulation of xenophagy" EXACT [GOC:TermGenie] synonym: "inhibition of xenophagy" NARROW [GOC:TermGenie] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:1904415 ! regulation of xenophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098792 ! xenophagy relationship: negatively_regulates GO:0098792 ! xenophagy created_by: pad creation_date: 2015-06-29T12:30:53Z [Term] id: GO:1904417 name: positive regulation of xenophagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). synonym: "activation of xenophagy" NARROW [GOC:TermGenie] synonym: "up regulation of xenophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of xenophagy" EXACT [GOC:TermGenie] synonym: "upregulation of xenophagy" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:1904415 ! regulation of xenophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098792 ! xenophagy relationship: positively_regulates GO:0098792 ! xenophagy created_by: pad creation_date: 2015-06-29T12:30:59Z [Term] id: GO:1904418 name: regulation of telomeric loop formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of t-loop formation" EXACT [GOC:TermGenie] is_a: GO:0032204 ! regulation of telomere maintenance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031627 ! telomeric loop formation relationship: regulates GO:0031627 ! telomeric loop formation created_by: nc creation_date: 2015-07-01T10:40:24Z [Term] id: GO:1904419 name: negative regulation of telomeric loop formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "down regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric loop formation" EXACT [GOC:TermGenie] synonym: "down-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric loop formation" EXACT [GOC:TermGenie] synonym: "downregulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric loop formation" EXACT [GOC:TermGenie] synonym: "inhibition of t-loop biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of t-loop formation" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric loop formation" NARROW [GOC:TermGenie] synonym: "negative regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of t-loop formation" EXACT [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904418 ! regulation of telomeric loop formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031627 ! telomeric loop formation relationship: negatively_regulates GO:0031627 ! telomeric loop formation created_by: nc creation_date: 2015-07-01T10:40:29Z [Term] id: GO:1904420 name: positive regulation of telomeric loop formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "activation of t-loop biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of t-loop formation" NARROW [GOC:TermGenie] synonym: "activation of telomeric loop formation" NARROW [GOC:TermGenie] synonym: "positive regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "up regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric loop formation" EXACT [GOC:TermGenie] synonym: "up-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric loop formation" EXACT [GOC:TermGenie] synonym: "upregulation of t-loop biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of t-loop formation" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric loop formation" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:1904418 ! regulation of telomeric loop formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031627 ! telomeric loop formation relationship: positively_regulates GO:0031627 ! telomeric loop formation created_by: nc creation_date: 2015-07-01T10:40:35Z [Term] id: GO:1904421 name: response to D-galactosamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-07-02T15:38:20Z [Term] id: GO:1904422 name: cellular response to D-galactosamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904421 ! response to D-galactosamine created_by: sl creation_date: 2015-07-02T15:38:36Z [Term] id: GO:1904423 name: dehydrodolichyl diphosphate synthase complex namespace: cellular_component def: "A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056] is_a: GO:1990234 ! transferase complex created_by: ew creation_date: 2015-07-02T19:51:40Z [Term] id: GO:1904424 name: regulation of GTP binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005525 ! GTP binding relationship: regulates GO:0005525 ! GTP binding created_by: sl creation_date: 2015-07-02T20:34:44Z [Term] id: GO:1904425 name: negative regulation of GTP binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] synonym: "down regulation of GTP binding" EXACT [GOC:TermGenie] synonym: "down-regulation of GTP binding" EXACT [GOC:TermGenie] synonym: "downregulation of GTP binding" EXACT [GOC:TermGenie] synonym: "inhibition of GTP binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1904424 ! regulation of GTP binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005525 ! GTP binding relationship: negatively_regulates GO:0005525 ! GTP binding created_by: sl creation_date: 2015-07-02T20:35:01Z [Term] id: GO:1904426 name: positive regulation of GTP binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] synonym: "activation of GTP binding" NARROW [GOC:TermGenie] synonym: "up regulation of GTP binding" EXACT [GOC:TermGenie] synonym: "up-regulation of GTP binding" EXACT [GOC:TermGenie] synonym: "upregulation of GTP binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1904424 ! regulation of GTP binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005525 ! GTP binding relationship: positively_regulates GO:0005525 ! GTP binding created_by: sl creation_date: 2015-07-02T20:35:07Z [Term] id: GO:1904427 name: positive regulation of calcium ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094] synonym: "activation of calcium ion membrane transport" NARROW [GOC:TermGenie] synonym: "activation of calcium ion transmembrane transport" NARROW [GOC:TermGenie] synonym: "activation of transmembrane calcium transport" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "positive regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "up-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] synonym: "upregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] is_a: GO:0051928 ! positive regulation of calcium ion transport is_a: GO:1903169 ! regulation of calcium ion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070588 ! calcium ion transmembrane transport relationship: positively_regulates GO:0070588 ! calcium ion transmembrane transport created_by: sl creation_date: 2015-07-02T20:44:25Z [Term] id: GO:1904428 name: negative regulation of tubulin deacetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation." [GO_REF:0000058, GOC:TermGenie, PMID:23886946] synonym: "down regulation of tubulin deacetylation" EXACT [GOC:TermGenie] synonym: "down-regulation of tubulin deacetylation" EXACT [GOC:TermGenie] synonym: "downregulation of tubulin deacetylation" EXACT [GOC:TermGenie] synonym: "inhibition of tubulin deacetylation" NARROW [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0090043 ! regulation of tubulin deacetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090042 ! tubulin deacetylation relationship: negatively_regulates GO:0090042 ! tubulin deacetylation created_by: sart creation_date: 2015-07-03T14:42:58Z [Term] id: GO:1904429 name: regulation of t-circle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "regulation of telomeric circle formation" EXACT [GOC:TermGenie] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090656 ! t-circle formation relationship: regulates GO:0090656 ! t-circle formation created_by: nc creation_date: 2015-07-03T15:15:45Z [Term] id: GO:1904430 name: negative regulation of t-circle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "down regulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "downregulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "inhibition of t-circle formation" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric circle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of telomeric circle formation" EXACT [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904429 ! regulation of t-circle formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090656 ! t-circle formation relationship: negatively_regulates GO:0090656 ! t-circle formation created_by: nc creation_date: 2015-07-03T15:15:52Z [Term] id: GO:1904431 name: positive regulation of t-circle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "activation of t-circle formation" NARROW [GOC:TermGenie] synonym: "activation of telomeric circle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "up regulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric circle formation" EXACT [GOC:TermGenie] synonym: "upregulation of t-circle formation" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric circle formation" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1904429 ! regulation of t-circle formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090656 ! t-circle formation relationship: positively_regulates GO:0090656 ! t-circle formation created_by: nc creation_date: 2015-07-03T15:15:58Z [Term] id: GO:1904432 name: regulation of ferrous iron binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008198 ! ferrous iron binding relationship: regulates GO:0008198 ! ferrous iron binding created_by: kom creation_date: 2015-07-06T13:46:30Z [Term] id: GO:1904433 name: negative regulation of ferrous iron binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "down regulation of ferrous iron binding" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrous iron binding" EXACT [GOC:TermGenie] synonym: "downregulation of ferrous iron binding" EXACT [GOC:TermGenie] synonym: "inhibition of ferrous iron binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1904432 ! regulation of ferrous iron binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008198 ! ferrous iron binding relationship: negatively_regulates GO:0008198 ! ferrous iron binding created_by: kom creation_date: 2015-07-06T13:46:36Z [Term] id: GO:1904434 name: positive regulation of ferrous iron binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "activation of ferrous iron binding" NARROW [GOC:TermGenie] synonym: "up regulation of ferrous iron binding" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrous iron binding" EXACT [GOC:TermGenie] synonym: "upregulation of ferrous iron binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1904432 ! regulation of ferrous iron binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008198 ! ferrous iron binding relationship: positively_regulates GO:0008198 ! ferrous iron binding created_by: kom creation_date: 2015-07-06T13:46:42Z [Term] id: GO:1904435 name: regulation of transferrin receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990459 ! transferrin receptor binding relationship: regulates GO:1990459 ! transferrin receptor binding created_by: kom creation_date: 2015-07-06T13:49:01Z [Term] id: GO:1904436 name: negative regulation of transferrin receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "down regulation of transferrin receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of transferrin receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of transferrin receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of transferrin receptor binding" NARROW [GOC:TermGenie] is_a: GO:1900121 ! negative regulation of receptor binding is_a: GO:1904435 ! regulation of transferrin receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990459 ! transferrin receptor binding relationship: negatively_regulates GO:1990459 ! transferrin receptor binding created_by: kom creation_date: 2015-07-06T13:49:07Z [Term] id: GO:1904437 name: positive regulation of transferrin receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "activation of transferrin receptor binding" NARROW [GOC:TermGenie] synonym: "up regulation of transferrin receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of transferrin receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of transferrin receptor binding" EXACT [GOC:TermGenie] is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:1904435 ! regulation of transferrin receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990459 ! transferrin receptor binding relationship: positively_regulates GO:1990459 ! transferrin receptor binding created_by: kom creation_date: 2015-07-06T13:49:13Z [Term] id: GO:1904438 name: regulation of iron ion import across plasma membrane namespace: biological_process alt_id: GO:1903989 def: "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "regulation of ferrous iron import into cell" RELATED [] is_a: GO:0034759 ! regulation of iron ion transmembrane transport is_a: GO:0050794 ! regulation of cellular process is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098711 ! iron ion import across plasma membrane relationship: regulates GO:0098711 ! iron ion import across plasma membrane created_by: rl creation_date: 2015-03-04T14:37:36Z [Term] id: GO:1904439 name: negative regulation of iron ion import across plasma membrane namespace: biological_process alt_id: GO:1903990 def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "down regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "down regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "down-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "downregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie] synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "negative regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "negative regulation of ferrous iron import into cell" RELATED [] is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1904438 ! regulation of iron ion import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098711 ! iron ion import across plasma membrane relationship: negatively_regulates GO:0098711 ! iron ion import across plasma membrane created_by: rl creation_date: 2015-07-06T13:49:58Z [Term] id: GO:1904440 name: positive regulation of iron ion import across plasma membrane namespace: biological_process alt_id: GO:1903991 def: "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie] synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "positive regulation of ferrous iron import across plasma membrane" RELATED [] synonym: "positive regulation of ferrous iron import into cell" RELATED [] synonym: "up regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "up regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "up-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] synonym: "upregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1904438 ! regulation of iron ion import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098711 ! iron ion import across plasma membrane relationship: positively_regulates GO:0098711 ! iron ion import across plasma membrane created_by: rl creation_date: 2015-07-06T13:50:04Z [Term] id: GO:1904441 name: regulation of thyroid gland epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] synonym: "regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990789 ! thyroid gland epithelial cell proliferation relationship: regulates GO:1990789 ! thyroid gland epithelial cell proliferation created_by: sl creation_date: 2015-07-06T15:41:09Z [Term] id: GO:1904442 name: negative regulation of thyroid gland epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] synonym: "down regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "down regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "down regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "down-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "down-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "downregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "downregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation relationship: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation created_by: sl creation_date: 2015-07-06T15:41:15Z [Term] id: GO:1904443 name: positive regulation of thyroid gland epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] synonym: "activation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "up-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "up-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] synonym: "upregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] synonym: "upregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation relationship: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation created_by: sl creation_date: 2015-07-06T15:41:21Z [Term] id: GO:1904444 name: regulation of establishment of Sertoli cell barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] synonym: "regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "regulation of establishment of SCB" EXACT [GOC:TermGenie] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development is_a: GO:2000018 ! regulation of male gonad development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097368 ! establishment of Sertoli cell barrier relationship: regulates GO:0097368 ! establishment of Sertoli cell barrier created_by: sl creation_date: 2015-07-06T16:00:41Z [Term] id: GO:1904445 name: negative regulation of establishment of Sertoli cell barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] synonym: "down regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of blood-testis barrier" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of BTB" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of SCB" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of SCB" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier is_a: GO:2000019 ! negative regulation of male gonad development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier relationship: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier created_by: sl creation_date: 2015-07-06T16:00:48Z [Term] id: GO:1904446 name: positive regulation of establishment of Sertoli cell barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] synonym: "activation of establishment of blood-testis barrier" NARROW [GOC:TermGenie] synonym: "activation of establishment of BTB" NARROW [GOC:TermGenie] synonym: "activation of establishment of SCB" NARROW [GOC:TermGenie] synonym: "activation of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of BTB" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of SCB" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier is_a: GO:2000020 ! positive regulation of male gonad development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier relationship: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier created_by: sl creation_date: 2015-07-06T16:00:54Z [Term] id: GO:1904447 name: folate import across plasma membrane namespace: biological_process def: "The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:19762432] synonym: "folate import into cell" EXACT [GOC:hal] synonym: "folic acid import across plasma membrane" RELATED [] is_a: GO:0098739 ! import across plasma membrane is_a: GO:0098838 ! folate transmembrane transport created_by: hal creation_date: 2015-07-07T15:32:33Z [Term] id: GO:1904448 name: regulation of aspartate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061528 ! aspartate secretion relationship: regulates GO:0061528 ! aspartate secretion created_by: sl creation_date: 2015-07-07T20:56:57Z [Term] id: GO:1904449 name: negative regulation of aspartate secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] synonym: "down regulation of aspartate secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartate secretion" EXACT [GOC:TermGenie] synonym: "downregulation of aspartate secretion" EXACT [GOC:TermGenie] synonym: "inhibition of aspartate secretion" NARROW [GOC:TermGenie] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903531 ! negative regulation of secretion by cell is_a: GO:1904448 ! regulation of aspartate secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061528 ! aspartate secretion relationship: negatively_regulates GO:0061528 ! aspartate secretion created_by: sl creation_date: 2015-07-07T20:57:04Z [Term] id: GO:1904450 name: positive regulation of aspartate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] synonym: "activation of aspartate secretion" NARROW [GOC:TermGenie] synonym: "up regulation of aspartate secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartate secretion" EXACT [GOC:TermGenie] synonym: "upregulation of aspartate secretion" EXACT [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903532 ! positive regulation of secretion by cell is_a: GO:1904448 ! regulation of aspartate secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061528 ! aspartate secretion relationship: positively_regulates GO:0061528 ! aspartate secretion created_by: sl creation_date: 2015-07-07T20:57:10Z [Term] id: GO:1904451 name: regulation of potassium:proton exchanging ATPase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] synonym: "regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] synonym: "regulation of proton pump activity" BROAD [GOC:TermGenie] is_a: GO:0010155 ! regulation of proton transport is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008900 ! potassium:proton exchanging ATPase activity relationship: regulates GO:0008900 ! potassium:proton exchanging ATPase activity created_by: sl creation_date: 2015-07-08T23:00:03Z [Term] id: GO:1904452 name: negative regulation of potassium:proton exchanging ATPase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] synonym: "down regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "down regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "down regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "down regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "down-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "down-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "downregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "downregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "downregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie] synonym: "inhibition of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "inhibition of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of H+-K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of H+/K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of H,K-ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "negative regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "negative regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity is_a: GO:1904451 ! regulation of potassium:proton exchanging ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008900 ! potassium:proton exchanging ATPase activity relationship: negatively_regulates GO:0008900 ! potassium:proton exchanging ATPase activity created_by: sl creation_date: 2015-07-08T23:00:09Z [Term] id: GO:1904453 name: positive regulation of potassium:proton exchanging ATPase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] synonym: "activation of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie] synonym: "activation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "activation of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of H+-K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of H+/K+-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of H,K-ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "positive regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "positive regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] synonym: "up regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "up regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "up regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "up regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "up-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "up-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] synonym: "upregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] synonym: "upregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] synonym: "upregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of H,K-ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity is_a: GO:1904451 ! regulation of potassium:proton exchanging ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008900 ! potassium:proton exchanging ATPase activity relationship: positively_regulates GO:0008900 ! potassium:proton exchanging ATPase activity created_by: sl creation_date: 2015-07-08T23:00:15Z [Term] id: GO:1904456 name: negative regulation of neuronal action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie] synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0051970 ! negative regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019228 ! neuronal action potential relationship: negatively_regulates GO:0019228 ! neuronal action potential created_by: sl creation_date: 2015-07-09T18:02:40Z [Term] id: GO:1904457 name: positive regulation of neuronal action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "activation of generation of action potential" RELATED [GOC:TermGenie] synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0051971 ! positive regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019228 ! neuronal action potential relationship: positively_regulates GO:0019228 ! neuronal action potential created_by: sl creation_date: 2015-07-09T18:02:46Z [Term] id: GO:1904458 name: regulation of substance P secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990772 ! substance P secretion relationship: regulates GO:1990772 ! substance P secretion created_by: sl creation_date: 2015-07-09T19:32:50Z [Term] id: GO:1904459 name: negative regulation of substance P secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "down regulation of substance P secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of substance P secretion" EXACT [GOC:TermGenie] synonym: "downregulation of substance P secretion" EXACT [GOC:TermGenie] synonym: "inhibition of substance P secretion" NARROW [GOC:TermGenie] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:1904458 ! regulation of substance P secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990772 ! substance P secretion relationship: negatively_regulates GO:1990772 ! substance P secretion created_by: sl creation_date: 2015-07-09T19:32:57Z [Term] id: GO:1904460 name: positive regulation of substance P secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] synonym: "activation of substance P secretion" NARROW [GOC:TermGenie] synonym: "up regulation of substance P secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of substance P secretion" EXACT [GOC:TermGenie] synonym: "upregulation of substance P secretion" EXACT [GOC:TermGenie] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:1904458 ! regulation of substance P secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990772 ! substance P secretion relationship: positively_regulates GO:1990772 ! substance P secretion created_by: sl creation_date: 2015-07-09T19:33:03Z [Term] id: GO:1904461 name: ergosteryl 3-beta-D-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] synonym: "ergosteryl 3-beta-D-glucoside metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016134 ! saponin metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process created_by: mcc creation_date: 2015-07-09T19:36:19Z [Term] id: GO:1904462 name: ergosteryl 3-beta-D-glucoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] synonym: "ergosteryl 3-beta-D-glucoside breakdown" EXACT [GOC:TermGenie] synonym: "ergosteryl 3-beta-D-glucoside catabolism" EXACT [GOC:TermGenie] synonym: "ergosteryl 3-beta-D-glucoside degradation" EXACT [GOC:TermGenie] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016136 ! saponin catabolic process is_a: GO:1901805 ! beta-glucoside catabolic process is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process created_by: mcc creation_date: 2015-07-09T19:36:25Z [Term] id: GO:1904463 name: ergosteryl 3-beta-D-glucoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] synonym: "ergosteryl 3-beta-D-glucoside anabolism" EXACT [GOC:TermGenie] synonym: "ergosteryl 3-beta-D-glucoside biosynthesis" EXACT [GOC:TermGenie] synonym: "ergosteryl 3-beta-D-glucoside formation" EXACT [GOC:TermGenie] synonym: "ergosteryl 3-beta-D-glucoside synthesis" EXACT [GOC:TermGenie] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016135 ! saponin biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process created_by: mcc creation_date: 2015-07-09T19:36:31Z [Term] id: GO:1904464 name: regulation of matrix metallopeptidase secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] synonym: "regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "regulation of MMP secretion" EXACT [GOC:TermGenie] is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990773 ! matrix metallopeptidase secretion relationship: regulates GO:1990773 ! matrix metallopeptidase secretion created_by: sl creation_date: 2015-07-09T19:46:17Z [Term] id: GO:1904465 name: negative regulation of matrix metallopeptidase secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] synonym: "down regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "down regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "down regulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "downregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "downregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "downregulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "inhibition of matrix metallopeptidase secretion" NARROW [GOC:TermGenie] synonym: "inhibition of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "inhibition of MMP secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of MMP secretion" EXACT [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion relationship: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion created_by: sl creation_date: 2015-07-09T19:46:24Z [Term] id: GO:1904466 name: positive regulation of matrix metallopeptidase secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] synonym: "activation of matrix metallopeptidase secretion" NARROW [GOC:TermGenie] synonym: "activation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "activation of MMP secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "up regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "up regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "up regulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of MMP secretion" EXACT [GOC:TermGenie] synonym: "upregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] synonym: "upregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] synonym: "upregulation of MMP secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990773 ! matrix metallopeptidase secretion relationship: positively_regulates GO:1990773 ! matrix metallopeptidase secretion created_by: sl creation_date: 2015-07-09T19:46:30Z [Term] id: GO:1904467 name: regulation of tumor necrosis factor secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990774 ! tumor necrosis factor secretion relationship: regulates GO:1990774 ! tumor necrosis factor secretion created_by: sl creation_date: 2015-07-09T19:50:02Z [Term] id: GO:1904468 name: negative regulation of tumor necrosis factor secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "down regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "down regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "down regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "down regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] synonym: "downregulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "downregulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "downregulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] synonym: "inhibition of cachectin secretion" NARROW [GOC:TermGenie] synonym: "inhibition of TNF secretion" NARROW [GOC:TermGenie] synonym: "inhibition of TNF superfamily, member 2 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of TNF-alpha secretion" NARROW [GOC:TermGenie] synonym: "inhibition of Tnfa secretion" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor alpha secretion" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor ligand superfamily member 2 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of tumor necrosis factor secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] is_a: GO:0032720 ! negative regulation of tumor necrosis factor production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1904467 ! regulation of tumor necrosis factor secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990774 ! tumor necrosis factor secretion relationship: negatively_regulates GO:1990774 ! tumor necrosis factor secretion created_by: sl creation_date: 2015-07-09T19:50:08Z [Term] id: GO:1904469 name: positive regulation of tumor necrosis factor secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "activation of cachectin secretion" NARROW [GOC:TermGenie] synonym: "activation of TNF secretion" NARROW [GOC:TermGenie] synonym: "activation of TNF superfamily, member 2 secretion" NARROW [GOC:TermGenie] synonym: "activation of TNF-alpha secretion" NARROW [GOC:TermGenie] synonym: "activation of Tnfa secretion" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor alpha secretion" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor ligand superfamily member 2 secretion" NARROW [GOC:TermGenie] synonym: "activation of tumor necrosis factor secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "up regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "up regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "up regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] synonym: "upregulation of cachectin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of TNF secretion" EXACT [GOC:TermGenie] synonym: "upregulation of TNF superfamily, member 2 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of TNF-alpha secretion" EXACT [GOC:TermGenie] synonym: "upregulation of Tnfa secretion" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor alpha secretion" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor ligand superfamily member 2 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of tumor necrosis factor secretion" EXACT [GOC:TermGenie] is_a: GO:0032760 ! positive regulation of tumor necrosis factor production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1904467 ! regulation of tumor necrosis factor secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990774 ! tumor necrosis factor secretion relationship: positively_regulates GO:1990774 ! tumor necrosis factor secretion created_by: sl creation_date: 2015-07-09T19:50:14Z [Term] id: GO:1904470 name: regulation of endothelin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990775 ! endothelin secretion relationship: regulates GO:1990775 ! endothelin secretion created_by: sl creation_date: 2015-07-09T19:57:57Z [Term] id: GO:1904471 name: negative regulation of endothelin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "down regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "downregulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of endothelin secretion" NARROW [GOC:TermGenie] synonym: "inhibition of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1904470 ! regulation of endothelin secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990775 ! endothelin secretion relationship: negatively_regulates GO:1990775 ! endothelin secretion created_by: sl creation_date: 2015-07-09T19:58:03Z [Term] id: GO:1904472 name: positive regulation of endothelin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "activation of endothelin secretion" NARROW [GOC:TermGenie] synonym: "activation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "activation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "up regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "up regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of EDN3 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1904470 ! regulation of endothelin secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990775 ! endothelin secretion relationship: positively_regulates GO:1990775 ! endothelin secretion created_by: sl creation_date: 2015-07-09T19:58:10Z [Term] id: GO:1904473 name: response to L-dopa namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] is_a: GO:0009636 ! response to toxic substance is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid is_a: GO:1904386 ! response to L-phenylalanine derivative created_by: sl creation_date: 2015-07-09T20:15:53Z [Term] id: GO:1904474 name: cellular response to L-dopa namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904387 ! cellular response to L-phenylalanine derivative is_a: GO:1904473 ! response to L-dopa created_by: sl creation_date: 2015-07-09T20:15:59Z [Term] id: GO:1904475 name: regulation of Ras GTPase binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] synonym: "regulation of Ras interactor activity" RELATED [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017016 ! Ras GTPase binding relationship: regulates GO:0017016 ! Ras GTPase binding created_by: sl creation_date: 2015-07-10T22:47:31Z [Term] id: GO:1904476 name: negative regulation of Ras GTPase binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] synonym: "down regulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "down regulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "down-regulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "down-regulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "downregulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "downregulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "inhibition of Ras GTPase binding" NARROW [GOC:TermGenie] synonym: "inhibition of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "negative regulation of Ras interactor activity" RELATED [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1904475 ! regulation of Ras GTPase binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017016 ! Ras GTPase binding relationship: negatively_regulates GO:0017016 ! Ras GTPase binding created_by: sl creation_date: 2015-07-10T22:47:38Z [Term] id: GO:1904477 name: positive regulation of Ras GTPase binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ras GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] synonym: "activation of Ras GTPase binding" NARROW [GOC:TermGenie] synonym: "activation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "positive regulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "up regulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "up regulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "up-regulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "up-regulation of Ras interactor activity" RELATED [GOC:TermGenie] synonym: "upregulation of Ras GTPase binding" EXACT [GOC:TermGenie] synonym: "upregulation of Ras interactor activity" RELATED [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1904475 ! regulation of Ras GTPase binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017016 ! Ras GTPase binding relationship: positively_regulates GO:0017016 ! Ras GTPase binding created_by: sl creation_date: 2015-07-10T22:47:43Z [Term] id: GO:1904478 name: regulation of intestinal absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050892 ! intestinal absorption relationship: regulates GO:0050892 ! intestinal absorption created_by: rl creation_date: 2015-07-13T15:58:47Z [Term] id: GO:1904479 name: negative regulation of intestinal absorption namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] synonym: "down regulation of intestinal absorption" EXACT [GOC:TermGenie] synonym: "down-regulation of intestinal absorption" EXACT [GOC:TermGenie] synonym: "downregulation of intestinal absorption" EXACT [GOC:TermGenie] synonym: "inhibition of intestinal absorption" NARROW [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0060457 ! negative regulation of digestive system process is_a: GO:1904478 ! regulation of intestinal absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050892 ! intestinal absorption relationship: negatively_regulates GO:0050892 ! intestinal absorption created_by: rl creation_date: 2015-07-13T15:58:54Z [Term] id: GO:1904480 name: positive regulation of intestinal absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] synonym: "activation of intestinal absorption" NARROW [GOC:TermGenie] synonym: "up regulation of intestinal absorption" EXACT [GOC:TermGenie] synonym: "up-regulation of intestinal absorption" EXACT [GOC:TermGenie] synonym: "upregulation of intestinal absorption" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0060456 ! positive regulation of digestive system process is_a: GO:1904478 ! regulation of intestinal absorption intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050892 ! intestinal absorption relationship: positively_regulates GO:0050892 ! intestinal absorption created_by: rl creation_date: 2015-07-13T15:59:00Z [Term] id: GO:1904481 name: response to tetrahydrofolate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: hal creation_date: 2015-07-14T14:49:17Z [Term] id: GO:1904482 name: cellular response to tetrahydrofolate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904481 ! response to tetrahydrofolate created_by: hal creation_date: 2015-07-14T14:49:23Z [Term] id: GO:1904483 name: synthetic cannabinoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with synthetic cannabinoid." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10700562] is_a: GO:0005488 ! binding created_by: mr creation_date: 2015-07-14T22:30:09Z [Term] id: GO:1904484 name: cloacal gland development namespace: biological_process def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421] is_a: GO:0048732 ! gland development created_by: mr creation_date: 2015-07-15T22:14:39Z [Term] id: GO:1904486 name: response to 17alpha-ethynylestradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: mr creation_date: 2015-07-15T22:31:36Z [Term] id: GO:1904487 name: cellular response to 17alpha-ethynylestradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904486 ! response to 17alpha-ethynylestradiol created_by: mr creation_date: 2015-07-15T22:31:42Z [Term] id: GO:1904488 name: regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] synonym: "regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process created_by: kmv creation_date: 2015-07-17T18:11:59Z [Term] id: GO:1904489 name: regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] synonym: "regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process created_by: kmv creation_date: 2015-07-17T18:12:06Z [Term] id: GO:1904490 name: negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "negative regulation of mtUPR by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0034514 ! mitochondrial unfolded protein response relationship: negatively_regulates GO:0034514 ! mitochondrial unfolded protein response created_by: kmv creation_date: 2015-07-17T18:15:13Z [Term] id: GO:1904491 name: protein localization to ciliary transition zone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230] synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium created_by: kmv creation_date: 2015-07-17T20:43:21Z [Term] id: GO:1904492 name: Ac-Asp-Glu binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ac-Asp-Glu." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754] is_a: GO:0043168 ! anion binding is_a: GO:1900750 ! oligopeptide binding created_by: hal creation_date: 2015-07-20T10:32:49Z [Term] id: GO:1904493 name: tetrahydrofolyl-poly(glutamate) polymer binding namespace: molecular_function def: "Interacting selectively and non-covalently with tetrahydrofolyl-poly(glutamate) polymer." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754] is_a: GO:0005488 ! binding created_by: hal creation_date: 2015-07-20T10:34:28Z [Term] id: GO:1904494 name: regulation of substance P secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:1904458 ! regulation of substance P secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990793 ! substance P secretion, neurotransmission relationship: regulates GO:1990793 ! substance P secretion, neurotransmission created_by: sl creation_date: 2015-07-21T19:09:04Z [Term] id: GO:1904495 name: negative regulation of substance P secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] synonym: "down regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of substance P secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:1904459 ! negative regulation of substance P secretion is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission relationship: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission created_by: sl creation_date: 2015-07-21T19:09:10Z [Term] id: GO:1904496 name: positive regulation of substance P secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] synonym: "activation of substance P secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:1904460 ! positive regulation of substance P secretion is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990793 ! substance P secretion, neurotransmission relationship: positively_regulates GO:1990793 ! substance P secretion, neurotransmission created_by: sl creation_date: 2015-07-21T19:09:16Z [Term] id: GO:1904497 name: heterochromatin assembly involved in chromatin silencing at centromere outer repeat region namespace: biological_process def: "Any heterochromatin assembly that is involved in chromatin silencing at the centromere outer repeat region." [GO_REF:0000060, GOC:TermGenie, PMID:24240238] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] is_a: GO:0070869 ! heterochromatin assembly involved in chromatin silencing intersection_of: GO:0031507 ! heterochromatin assembly intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region created_by: mah creation_date: 2015-07-22T14:25:43Z [Term] id: GO:1904498 name: protein localization to mitotic actomyosin contractile ring namespace: biological_process def: "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25688133] synonym: "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "protein localization to actomyosin contractile ring during mitotic cytokinesis" RELATED [] synonym: "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [] synonym: "protein localization to mitotic actomyosin contractile ring" EXACT [] is_a: GO:1990179 ! protein localization to actomyosin contractile ring intersection_of: GO:1990179 ! protein localization to actomyosin contractile ring intersection_of: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0000281 ! mitotic cytokinesis created_by: mah creation_date: 2015-07-22T14:30:57Z [Term] id: GO:1904499 name: regulation of chromatin-mediated maintenance of transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048096 ! chromatin-mediated maintenance of transcription relationship: regulates GO:0048096 ! chromatin-mediated maintenance of transcription created_by: nc creation_date: 2015-07-24T09:31:08Z [Term] id: GO:1904500 name: negative regulation of chromatin-mediated maintenance of transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "down regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie] is_a: GO:1904499 ! regulation of chromatin-mediated maintenance of transcription is_a: GO:1905268 ! negative regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription relationship: negatively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription created_by: nc creation_date: 2015-07-24T09:31:14Z [Term] id: GO:1904501 name: positive regulation of chromatin-mediated maintenance of transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "activation of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie] synonym: "up regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1904499 ! regulation of chromatin-mediated maintenance of transcription is_a: GO:1905269 ! positive regulation of chromatin organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription relationship: positively_regulates GO:0048096 ! chromatin-mediated maintenance of transcription created_by: nc creation_date: 2015-07-24T09:31:20Z [Term] id: GO:1904502 name: regulation of lipophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061724 ! lipophagy relationship: regulates GO:0061724 ! lipophagy created_by: dph creation_date: 2015-07-24T11:37:12Z [Term] id: GO:1904503 name: negative regulation of lipophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] synonym: "down regulation of lipophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of lipophagy" EXACT [GOC:TermGenie] synonym: "downregulation of lipophagy" EXACT [GOC:TermGenie] synonym: "inhibition of lipophagy" NARROW [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:1904502 ! regulation of lipophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061724 ! lipophagy relationship: negatively_regulates GO:0061724 ! lipophagy created_by: dph creation_date: 2015-07-24T11:37:18Z [Term] id: GO:1904504 name: positive regulation of lipophagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] synonym: "activation of lipophagy" NARROW [GOC:TermGenie] synonym: "up regulation of lipophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of lipophagy" EXACT [GOC:TermGenie] synonym: "upregulation of lipophagy" EXACT [GOC:TermGenie] is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:1904502 ! regulation of lipophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061724 ! lipophagy relationship: positively_regulates GO:0061724 ! lipophagy created_by: dph creation_date: 2015-07-24T11:37:24Z [Term] id: GO:1904505 name: regulation of telomere maintenance in response to DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043247 ! telomere maintenance in response to DNA damage relationship: regulates GO:0043247 ! telomere maintenance in response to DNA damage created_by: nc creation_date: 2015-07-24T16:05:55Z [Term] id: GO:1904506 name: negative regulation of telomere maintenance in response to DNA damage namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "down regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "down regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] synonym: "downregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] synonym: "inhibition of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie] synonym: "inhibition of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage relationship: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage created_by: nc creation_date: 2015-07-24T16:06:02Z [Term] id: GO:1904507 name: positive regulation of telomere maintenance in response to DNA damage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "activation of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie] synonym: "activation of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "up regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "up regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] synonym: "upregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage relationship: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage created_by: nc creation_date: 2015-07-24T16:06:09Z [Term] id: GO:1904508 name: regulation of protein localization to basolateral plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] synonym: "regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903361 ! protein localization to basolateral plasma membrane relationship: regulates GO:1903361 ! protein localization to basolateral plasma membrane created_by: kmv creation_date: 2015-07-24T17:56:26Z [Term] id: GO:1904509 name: negative regulation of protein localization to basolateral plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] synonym: "down regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane relationship: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane created_by: kmv creation_date: 2015-07-24T17:56:32Z [Term] id: GO:1904510 name: positive regulation of protein localization to basolateral plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] synonym: "activation of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane relationship: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane created_by: kmv creation_date: 2015-07-24T17:56:38Z [Term] id: GO:1904511 name: cytoplasmic microtubule plus-end namespace: cellular_component def: "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152] synonym: "growing microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie] synonym: "growing microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] synonym: "microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie] synonym: "microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] synonym: "microtubule plus-end of cytoplasmic microtubule" EXACT [GOC:TermGenie] synonym: "microtubule plus-end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] is_a: GO:0035371 ! microtubule plus-end intersection_of: GO:0035371 ! microtubule plus-end intersection_of: part_of GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005881 ! cytoplasmic microtubule created_by: mah creation_date: 2015-07-27T13:05:11Z [Term] id: GO:1904512 name: regulation of initiation of premeiotic DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] synonym: "regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072691 ! initiation of premeiotic DNA replication relationship: regulates GO:0072691 ! initiation of premeiotic DNA replication created_by: mah creation_date: 2015-07-28T12:59:17Z [Term] id: GO:1904513 name: negative regulation of initiation of premeiotic DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] synonym: "down regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "down regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "down-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "downregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "downregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "inhibition of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "inhibition of premeiotic DNA replication initiation" NARROW [GOC:TermGenie] synonym: "negative regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "negative regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication relationship: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication created_by: mah creation_date: 2015-07-28T12:59:23Z [Term] id: GO:1904514 name: positive regulation of initiation of premeiotic DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] synonym: "activation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "activation of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie] synonym: "activation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "activation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "activation of premeiotic DNA replication initiation" NARROW [GOC:TermGenie] synonym: "positive regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "positive regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "positive regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "up regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "up regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "up regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "up regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "up-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "up-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "up-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "upregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "upregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "upregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "upregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072691 ! initiation of premeiotic DNA replication relationship: positively_regulates GO:0072691 ! initiation of premeiotic DNA replication created_by: mah creation_date: 2015-07-28T12:59:29Z [Term] id: GO:1904515 name: positive regulation of TORC2 signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25590601] synonym: "activation of TORC2 signal transduction" NARROW [GOC:TermGenie] synonym: "activation of TORC2 signaling" NARROW [GOC:TermGenie] synonym: "positive regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of TORC2 signaling" EXACT [GOC:TermGenie] synonym: "up-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of TORC2 signaling" EXACT [GOC:TermGenie] synonym: "upregulation of TORC2 signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of TORC2 signaling" EXACT [GOC:TermGenie] is_a: GO:0032008 ! positive regulation of TOR signaling is_a: GO:1903939 ! regulation of TORC2 signaling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038203 ! TORC2 signaling relationship: positively_regulates GO:0038203 ! TORC2 signaling created_by: al creation_date: 2015-07-28T16:09:55Z [Term] id: GO:1904516 name: myofibroblast cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myofibroblast cell." [GO_REF:0000085, GOC:TermGenie, PMID:23026405] synonym: "MFB apoptosis" NARROW [GOC:TermGenie] synonym: "MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process created_by: sl creation_date: 2015-07-28T18:29:08Z [Term] id: GO:1904517 name: MgATP(2-) binding namespace: molecular_function def: "Interacting selectively and non-covalently with MgATP(2-)." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:20086079] is_a: GO:0005488 ! binding created_by: bhm creation_date: 2015-07-29T13:40:02Z [Term] id: GO:1904518 name: protein localization to cytoplasmic microtubule plus-end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:15772152] synonym: "protein localisation in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] synonym: "protein localisation to cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] synonym: "protein localization in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] is_a: GO:1904825 ! protein localization to microtubule plus-end is_a: GO:1905755 ! protein localization to cytoplasmic microtubule created_by: mah creation_date: 2015-07-29T14:46:05Z [Term] id: GO:1904519 name: protein localization to microtubule minus-end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end." [GO_REF:0000087, GOC:TermGenie, PMID:25987607] synonym: "protein localisation in microtubule minus-end" EXACT [GOC:TermGenie] synonym: "protein localisation to microtubule minus-end" EXACT [GOC:TermGenie] synonym: "protein localization in microtubule minus-end" EXACT [GOC:TermGenie] is_a: GO:1905725 ! protein localization to microtubule end created_by: mah creation_date: 2015-07-29T14:46:11Z [Term] id: GO:1904520 name: regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904516 ! myofibroblast cell apoptotic process relationship: regulates GO:1904516 ! myofibroblast cell apoptotic process created_by: sl creation_date: 2015-07-29T15:52:14Z [Term] id: GO:1904521 name: negative regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "down regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of MFB apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process relationship: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process created_by: sl creation_date: 2015-07-29T15:52:20Z [Term] id: GO:1904522 name: positive regulation of myofibroblast cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] synonym: "activation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "activation of MFB apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of MFB apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of MFB apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process relationship: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process created_by: sl creation_date: 2015-07-29T15:52:26Z [Term] id: GO:1904523 name: regulation of DNA amplification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006277 ! DNA amplification relationship: regulates GO:0006277 ! DNA amplification created_by: mcc creation_date: 2015-07-29T16:24:13Z [Term] id: GO:1904524 name: negative regulation of DNA amplification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] synonym: "down regulation of DNA amplification" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA amplification" EXACT [GOC:TermGenie] synonym: "downregulation of DNA amplification" EXACT [GOC:TermGenie] synonym: "inhibition of DNA amplification" NARROW [GOC:TermGenie] is_a: GO:1904523 ! regulation of DNA amplification is_a: GO:2000279 ! negative regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006277 ! DNA amplification relationship: negatively_regulates GO:0006277 ! DNA amplification created_by: mcc creation_date: 2015-07-29T16:24:19Z [Term] id: GO:1904525 name: positive regulation of DNA amplification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] synonym: "activation of DNA amplification" NARROW [GOC:TermGenie] synonym: "up regulation of DNA amplification" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA amplification" EXACT [GOC:TermGenie] synonym: "upregulation of DNA amplification" EXACT [GOC:TermGenie] is_a: GO:1904523 ! regulation of DNA amplification is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006277 ! DNA amplification relationship: positively_regulates GO:0006277 ! DNA amplification created_by: mcc creation_date: 2015-07-29T16:24:25Z [Term] id: GO:1904526 name: regulation of microtubule binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008017 ! microtubule binding relationship: regulates GO:0008017 ! microtubule binding created_by: als creation_date: 2015-07-30T10:32:13Z [Term] id: GO:1904527 name: negative regulation of microtubule binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "down regulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "down regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "down-regulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "down-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "downregulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "downregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "inhibition of microtubule binding" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "inhibition of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "negative regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "negative regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1904526 ! regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008017 ! microtubule binding relationship: negatively_regulates GO:0008017 ! microtubule binding created_by: als creation_date: 2015-07-30T10:32:29Z [Term] id: GO:1904528 name: positive regulation of microtubule binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "activation of microtubule binding" NARROW [GOC:TermGenie] synonym: "activation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "activation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "positive regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "positive regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "up regulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "up regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "up-regulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "up-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] synonym: "upregulation of microtubule binding" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule severing activity" RELATED [GOC:TermGenie] synonym: "upregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1904526 ! regulation of microtubule binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008017 ! microtubule binding relationship: positively_regulates GO:0008017 ! microtubule binding created_by: als creation_date: 2015-07-30T10:32:36Z [Term] id: GO:1904529 name: regulation of actin filament binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "regulation of F-actin binding" EXACT [GOC:TermGenie] is_a: GO:1904616 ! regulation of actin binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051015 ! actin filament binding relationship: regulates GO:0051015 ! actin filament binding created_by: als creation_date: 2015-07-30T10:41:49Z [Term] id: GO:1904530 name: negative regulation of actin filament binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "down regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "down regulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "down regulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "down-regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "down-regulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "down-regulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "downregulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "downregulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "downregulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "inhibition of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "inhibition of actin filament binding" NARROW [GOC:TermGenie] synonym: "inhibition of F-actin binding" NARROW [GOC:TermGenie] synonym: "negative regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "negative regulation of F-actin binding" EXACT [GOC:TermGenie] is_a: GO:1904529 ! regulation of actin filament binding is_a: GO:1904617 ! negative regulation of actin binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051015 ! actin filament binding relationship: negatively_regulates GO:0051015 ! actin filament binding created_by: als creation_date: 2015-07-30T10:41:55Z [Term] id: GO:1904531 name: positive regulation of actin filament binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] synonym: "activation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "activation of actin filament binding" NARROW [GOC:TermGenie] synonym: "activation of F-actin binding" NARROW [GOC:TermGenie] synonym: "positive regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "positive regulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "up regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "up regulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "up regulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "up-regulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "up-regulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "up-regulation of F-actin binding" EXACT [GOC:TermGenie] synonym: "upregulation of actin cross-linking activity" RELATED [GOC:TermGenie] synonym: "upregulation of actin filament binding" EXACT [GOC:TermGenie] synonym: "upregulation of F-actin binding" EXACT [GOC:TermGenie] is_a: GO:1904529 ! regulation of actin filament binding is_a: GO:1904618 ! positive regulation of actin binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051015 ! actin filament binding relationship: positively_regulates GO:0051015 ! actin filament binding created_by: als creation_date: 2015-07-30T10:42:01Z [Term] id: GO:1904532 name: obsolete ATP-dependent microtubule motor activity, minus-end-directed involved in microtubule-based movement namespace: molecular_function def: "OBSOLETE. Any ATP-dependent microtubule motor activity, minus-end-directed that is involved in microtubule-based movement." [GO_REF:0000061, GOC:TermGenie, PMID:25987607] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: vw creation_date: 2015-07-31T06:45:48Z [Term] id: GO:1904533 name: regulation of telomeric loop disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "regulation of T loop disassembly" EXACT [GOC:TermGenie] is_a: GO:0032204 ! regulation of telomere maintenance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090657 ! telomeric loop disassembly relationship: regulates GO:0090657 ! telomeric loop disassembly created_by: nc creation_date: 2015-07-31T17:14:58Z [Term] id: GO:1904534 name: negative regulation of telomeric loop disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "down regulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric loop disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of T loop disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric loop disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of T loop disassembly" EXACT [GOC:TermGenie] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:1904533 ! regulation of telomeric loop disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090657 ! telomeric loop disassembly relationship: negatively_regulates GO:0090657 ! telomeric loop disassembly created_by: nc creation_date: 2015-07-31T17:15:04Z [Term] id: GO:1904535 name: positive regulation of telomeric loop disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] synonym: "activation of T loop disassembly" NARROW [GOC:TermGenie] synonym: "activation of telomeric loop disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of T loop disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric loop disassembly" EXACT [GOC:TermGenie] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:1904533 ! regulation of telomeric loop disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090657 ! telomeric loop disassembly relationship: positively_regulates GO:0090657 ! telomeric loop disassembly created_by: nc creation_date: 2015-07-31T17:15:10Z [Term] id: GO:1904536 name: regulation of mitotic telomere tethering at nuclear periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery relationship: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery created_by: al creation_date: 2015-08-04T14:24:26Z [Term] id: GO:1904537 name: negative regulation of mitotic telomere tethering at nuclear periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349] synonym: "down regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic telomere tethering at nuclear periphery" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1904536 ! regulation of mitotic telomere tethering at nuclear periphery intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery relationship: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery created_by: al creation_date: 2015-08-04T14:24:32Z [Term] id: GO:1904538 name: regulation of glycolytic process through fructose-6-phosphate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] synonym: "regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] is_a: GO:0006110 ! regulation of glycolytic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate relationship: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate created_by: dph creation_date: 2015-08-07T11:35:10Z [Term] id: GO:1904539 name: negative regulation of glycolytic process through fructose-6-phosphate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] synonym: "down regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "down regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "down-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "down-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "downregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "downregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "inhibition of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie] synonym: "inhibition of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie] synonym: "negative regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] is_a: GO:0045820 ! negative regulation of glycolytic process is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate relationship: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate created_by: dph creation_date: 2015-08-07T11:35:16Z [Term] id: GO:1904540 name: positive regulation of glycolytic process through fructose-6-phosphate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] synonym: "activation of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie] synonym: "activation of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie] synonym: "positive regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "up regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "up regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "up-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "up-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "upregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] synonym: "upregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] is_a: GO:0045821 ! positive regulation of glycolytic process is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate relationship: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate created_by: dph creation_date: 2015-08-07T11:35:22Z [Term] id: GO:1904541 name: fungal-type cell wall disassembly involved in conjugation with cellular fusion namespace: biological_process def: "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517] synonym: "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie] synonym: "fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie] is_a: GO:0070871 ! cell wall organization involved in conjugation with cellular fusion is_a: GO:0071853 ! fungal-type cell wall disassembly intersection_of: GO:0071853 ! fungal-type cell wall disassembly intersection_of: part_of GO:0000747 ! conjugation with cellular fusion created_by: al creation_date: 2015-08-10T17:12:51Z [Term] id: GO:1904542 name: regulation of free ubiquitin chain polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010994 ! free ubiquitin chain polymerization relationship: regulates GO:0010994 ! free ubiquitin chain polymerization created_by: pad creation_date: 2015-08-11T11:44:53Z [Term] id: GO:1904543 name: negative regulation of free ubiquitin chain polymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). synonym: "down regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] synonym: "downregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] synonym: "inhibition of free ubiquitin chain polymerization" NARROW [GOC:TermGenie] is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization relationship: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization created_by: pad creation_date: 2015-08-11T11:45:00Z [Term] id: GO:1904544 name: positive regulation of free ubiquitin chain polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). synonym: "activation of free ubiquitin chain polymerization" NARROW [GOC:TermGenie] synonym: "up regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] synonym: "upregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010994 ! free ubiquitin chain polymerization relationship: positively_regulates GO:0010994 ! free ubiquitin chain polymerization created_by: pad creation_date: 2015-08-11T11:45:06Z [Term] id: GO:1904546 name: obsolete negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway namespace: biological_process def: "OBSOLETE. Any negative regulation of cAMP-dependent protein kinase activity that is involved in negative regulation of glucose mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:21118717] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2015-08-12T09:48:46Z [Term] id: GO:1904547 name: regulation of cellular response to glucose starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to glucose starvation." [GO_REF:0000058, GOC:TermGenie, PMID:21118717] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042149 ! cellular response to glucose starvation relationship: regulates GO:0042149 ! cellular response to glucose starvation created_by: al creation_date: 2015-08-12T09:57:52Z [Term] id: GO:1904550 name: response to arachidonic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163] is_a: GO:0070542 ! response to fatty acid created_by: sl creation_date: 2015-08-13T20:53:24Z [Term] id: GO:1904551 name: cellular response to arachidonic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:1904550 ! response to arachidonic acid created_by: sl creation_date: 2015-08-13T20:53:31Z [Term] id: GO:1904552 name: regulation of chemotaxis to arachidonic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034670 ! chemotaxis to arachidonic acid relationship: regulates GO:0034670 ! chemotaxis to arachidonic acid created_by: sl creation_date: 2015-08-13T21:08:14Z [Term] id: GO:1904553 name: negative regulation of chemotaxis to arachidonic acid namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] synonym: "down regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] synonym: "downregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] synonym: "inhibition of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034670 ! chemotaxis to arachidonic acid relationship: negatively_regulates GO:0034670 ! chemotaxis to arachidonic acid created_by: sl creation_date: 2015-08-13T21:08:20Z [Term] id: GO:1904554 name: positive regulation of chemotaxis to arachidonic acid namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] synonym: "activation of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie] synonym: "up regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] synonym: "up-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] synonym: "upregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034670 ! chemotaxis to arachidonic acid relationship: positively_regulates GO:0034670 ! chemotaxis to arachidonic acid created_by: sl creation_date: 2015-08-13T21:08:27Z [Term] id: GO:1904555 name: L-proline transmembrane transport namespace: biological_process def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0035524 ! proline transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr creation_date: 2015-08-14T14:21:06Z [Term] id: GO:1904556 name: L-tryptophan transmembrane transport namespace: biological_process def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015827 ! tryptophan transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr creation_date: 2015-08-14T14:21:13Z [Term] id: GO:1904557 name: L-alanine transmembrane transport namespace: biological_process def: "The directed movement of L-alanine across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] is_a: GO:0015808 ! L-alanine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr creation_date: 2015-08-14T14:21:29Z [Term] id: GO:1904558 name: response to dextromethorphan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0009636 ! response to toxic substance is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0042493 ! response to drug is_a: GO:0045472 ! response to ether created_by: mr creation_date: 2015-08-14T16:09:17Z [Term] id: GO:1904559 name: cellular response to dextromethorphan namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071317 ! cellular response to isoquinoline alkaloid is_a: GO:0071362 ! cellular response to ether is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904558 ! response to dextromethorphan created_by: mr creation_date: 2015-08-14T16:09:24Z [Term] id: GO:1904560 name: response to diphenidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0097305 ! response to alcohol created_by: mr creation_date: 2015-08-14T16:09:31Z [Term] id: GO:1904561 name: cellular response to diphenidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1904560 ! response to diphenidol created_by: mr creation_date: 2015-08-14T16:09:37Z [Term] id: GO:1904562 name: phosphatidylinositol 5-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588] synonym: "phosphatidylinositol 5-phosphate metabolism" EXACT [GOC:TermGenie] is_a: GO:0046488 ! phosphatidylinositol metabolic process created_by: dph creation_date: 2015-08-18T16:21:44Z [Term] id: GO:1904563 name: phosphatidylinositol 5-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588] synonym: "phosphatidylinositol 5-phosphate anabolism" EXACT [GOC:TermGenie] synonym: "phosphatidylinositol 5-phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "phosphatidylinositol 5-phosphate formation" EXACT [GOC:TermGenie] synonym: "phosphatidylinositol 5-phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006661 ! phosphatidylinositol biosynthetic process is_a: GO:1904562 ! phosphatidylinositol 5-phosphate metabolic process created_by: dph creation_date: 2015-08-18T16:21:50Z [Term] id: GO:1904564 name: Nbp35-Cfd1 ATPase complex namespace: cellular_component def: "An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1." [GO_REF:0000088, GOC:bhm, GOC:rb, GOC:TermGenie, PMID:26195633] comment: An example of this is the yeast Nbp35-Cfd1 complex (IDA). xref: IntAct:EBI-11666137 is_a: GO:1904949 ! ATPase complex is_a: GO:1990229 ! iron-sulfur cluster assembly complex created_by: rb creation_date: 2015-08-18T22:50:29Z [Term] id: GO:1904565 name: response to 1-oleoyl-sn-glycerol 3-phosphate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919] synonym: "response to 1-oleoyl lysophosphatidic acid" EXACT [] synonym: "response to LPA" EXACT [] synonym: "response to lysophosphatidic acid" EXACT [] synonym: "response to oleoyl lysophosphatidic acid" EXACT [] synonym: "response to oleoyl-L-alpha-lysophosphatidic acid" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-08-19T15:36:48Z [Term] id: GO:1904566 name: cellular response to 1-oleoyl-sn-glycerol 3-phosphate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919] synonym: "cellular response to 1-oleoyl lysophosphatidic acid" EXACT [] synonym: "cellular response to LPA" EXACT [] synonym: "cellular response to lysophosphatidic acid" EXACT [] synonym: "cellular response to oleoyl lysophosphatidic acid" EXACT [] synonym: "cellular response to oleoyl-L-alpha-lysophosphatidic acid" EXACT [] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904565 ! response to 1-oleoyl-sn-glycerol 3-phosphate created_by: sl creation_date: 2015-08-19T15:37:05Z [Term] id: GO:1904567 name: response to wortmannin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] synonym: "response to wartmannin" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-19T16:22:28Z [Term] id: GO:1904568 name: cellular response to wortmannin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] synonym: "cellular response to wartmannin" EXACT [] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904567 ! response to wortmannin created_by: sl creation_date: 2015-08-19T16:22:34Z [Term] id: GO:1904569 name: regulation of selenocysteine incorporation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001514 ! selenocysteine incorporation relationship: regulates GO:0001514 ! selenocysteine incorporation created_by: sl creation_date: 2015-08-19T17:26:38Z [Term] id: GO:1904570 name: negative regulation of selenocysteine incorporation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] synonym: "down regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] synonym: "down-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] synonym: "downregulation of selenocysteine incorporation" EXACT [GOC:TermGenie] synonym: "inhibition of selenocysteine incorporation" NARROW [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:1904569 ! regulation of selenocysteine incorporation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001514 ! selenocysteine incorporation relationship: negatively_regulates GO:0001514 ! selenocysteine incorporation created_by: sl creation_date: 2015-08-19T17:26:44Z [Term] id: GO:1904571 name: positive regulation of selenocysteine incorporation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] synonym: "activation of selenocysteine incorporation" NARROW [GOC:TermGenie] synonym: "up regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] synonym: "up-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] synonym: "upregulation of selenocysteine incorporation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1904569 ! regulation of selenocysteine incorporation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001514 ! selenocysteine incorporation relationship: positively_regulates GO:0001514 ! selenocysteine incorporation created_by: sl creation_date: 2015-08-19T17:26:50Z [Term] id: GO:1904572 name: negative regulation of mRNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] synonym: "down regulation of mRNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of mRNA binding" NARROW [GOC:TermGenie] is_a: GO:1902415 ! regulation of mRNA binding is_a: GO:1905215 ! negative regulation of RNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003729 ! mRNA binding relationship: negatively_regulates GO:0003729 ! mRNA binding created_by: sl creation_date: 2015-08-19T17:51:03Z [Term] id: GO:1904573 name: regulation of selenocysteine insertion sequence binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] synonym: "regulation of SECIS binding" EXACT [GOC:TermGenie] is_a: GO:1902415 ! regulation of mRNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035368 ! selenocysteine insertion sequence binding relationship: regulates GO:0035368 ! selenocysteine insertion sequence binding created_by: sl creation_date: 2015-08-19T17:51:09Z [Term] id: GO:1904574 name: negative regulation of selenocysteine insertion sequence binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] synonym: "down regulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "down regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] synonym: "down-regulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "down-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] synonym: "downregulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "downregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] synonym: "inhibition of SECIS binding" NARROW [GOC:TermGenie] synonym: "inhibition of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie] synonym: "negative regulation of SECIS binding" EXACT [GOC:TermGenie] is_a: GO:1904572 ! negative regulation of mRNA binding is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035368 ! selenocysteine insertion sequence binding relationship: negatively_regulates GO:0035368 ! selenocysteine insertion sequence binding created_by: sl creation_date: 2015-08-19T17:51:15Z [Term] id: GO:1904575 name: positive regulation of selenocysteine insertion sequence binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] synonym: "activation of SECIS binding" NARROW [GOC:TermGenie] synonym: "activation of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie] synonym: "positive regulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "up regulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "up regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] synonym: "up-regulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "up-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] synonym: "upregulation of SECIS binding" EXACT [GOC:TermGenie] synonym: "upregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] is_a: GO:1902416 ! positive regulation of mRNA binding is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035368 ! selenocysteine insertion sequence binding relationship: positively_regulates GO:0035368 ! selenocysteine insertion sequence binding created_by: sl creation_date: 2015-08-19T17:51:21Z [Term] id: GO:1904576 name: response to tunicamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] is_a: GO:0046677 ! response to antibiotic created_by: sl creation_date: 2015-08-19T18:01:52Z [Term] id: GO:1904577 name: cellular response to tunicamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1904576 ! response to tunicamycin created_by: sl creation_date: 2015-08-19T18:01:58Z [Term] id: GO:1904578 name: response to thapsigargin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-08-19T18:06:22Z [Term] id: GO:1904579 name: cellular response to thapsigargin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904578 ! response to thapsigargin created_by: sl creation_date: 2015-08-19T18:06:28Z [Term] id: GO:1904580 name: regulation of intracellular mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] synonym: "regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008298 ! intracellular mRNA localization relationship: regulates GO:0008298 ! intracellular mRNA localization created_by: sl creation_date: 2015-08-19T23:40:25Z [Term] id: GO:1904581 name: negative regulation of intracellular mRNA localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] synonym: "down regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "down regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "down regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "down-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "down-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "downregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "downregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "inhibition of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular mRNA localisation" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular mRNA localization" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA localization, intracellular" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "negative regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "negative regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1904580 ! regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008298 ! intracellular mRNA localization relationship: negatively_regulates GO:0008298 ! intracellular mRNA localization created_by: sl creation_date: 2015-08-19T23:40:32Z [Term] id: GO:1904582 name: positive regulation of intracellular mRNA localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] synonym: "activation of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie] synonym: "activation of intracellular mRNA localisation" NARROW [GOC:TermGenie] synonym: "activation of intracellular mRNA localization" NARROW [GOC:TermGenie] synonym: "activation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "activation of mRNA localization, intracellular" NARROW [GOC:TermGenie] synonym: "activation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "positive regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "positive regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "up regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "up regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "up regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "up-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "up-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] synonym: "upregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular mRNA localization" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] synonym: "upregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1904580 ! regulation of intracellular mRNA localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008298 ! intracellular mRNA localization relationship: positively_regulates GO:0008298 ! intracellular mRNA localization created_by: sl creation_date: 2015-08-19T23:40:38Z [Term] id: GO:1904583 name: response to polyamine macromolecule namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] synonym: "response to polyamine" EXACT [] synonym: "response to polyamines" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound created_by: sl creation_date: 2015-08-20T14:35:26Z [Term] id: GO:1904584 name: cellular response to polyamine macromolecule namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] synonym: "cellular response to polyamine" EXACT [] synonym: "cellular response to polyamines" EXACT [] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904583 ! response to polyamine macromolecule created_by: sl creation_date: 2015-08-20T14:35:32Z [Term] id: GO:1904585 name: response to putrescine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] synonym: "response to 1,4-Butanediamine" EXACT [] synonym: "response to 1,4-Diaminobutane" EXACT [] synonym: "response to tetramethylenediamine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0060359 ! response to ammonium ion created_by: sl creation_date: 2015-08-20T14:35:39Z [Term] id: GO:1904586 name: cellular response to putrescine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] synonym: "cellular response to 1,4-Butanediamine" EXACT [] synonym: "cellular response to 1,4-Diaminobutane" EXACT [] synonym: "cellular response to tetramethylenediamine" EXACT [] is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904585 ! response to putrescine created_by: sl creation_date: 2015-08-20T14:35:45Z [Term] id: GO:1904587 name: response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "response to glycoproteins" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-08-20T16:46:24Z [Term] id: GO:1904588 name: cellular response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "cellular response to glycoproteins" EXACT [] is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904587 ! response to glycoprotein created_by: sl creation_date: 2015-08-20T16:46:30Z [Term] id: GO:1904589 name: regulation of protein import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] synonym: "regulation of protein uptake" EXACT [GOC:TermGenie] is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017038 ! protein import relationship: regulates GO:0017038 ! protein import created_by: sl creation_date: 2015-08-20T21:26:30Z [Term] id: GO:1904590 name: negative regulation of protein import namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] synonym: "down regulation of protein import" EXACT [GOC:TermGenie] synonym: "down regulation of protein uptake" EXACT [GOC:TermGenie] synonym: "down-regulation of protein import" EXACT [GOC:TermGenie] synonym: "down-regulation of protein uptake" EXACT [GOC:TermGenie] synonym: "downregulation of protein import" EXACT [GOC:TermGenie] synonym: "downregulation of protein uptake" EXACT [GOC:TermGenie] synonym: "inhibition of protein import" NARROW [GOC:TermGenie] synonym: "inhibition of protein uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of protein uptake" EXACT [GOC:TermGenie] is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1904589 ! regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017038 ! protein import relationship: negatively_regulates GO:0017038 ! protein import created_by: sl creation_date: 2015-08-20T21:26:36Z [Term] id: GO:1904591 name: positive regulation of protein import namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] synonym: "activation of protein import" NARROW [GOC:TermGenie] synonym: "activation of protein uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of protein uptake" EXACT [GOC:TermGenie] synonym: "up regulation of protein import" EXACT [GOC:TermGenie] synonym: "up regulation of protein uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of protein import" EXACT [GOC:TermGenie] synonym: "up-regulation of protein uptake" EXACT [GOC:TermGenie] synonym: "upregulation of protein import" EXACT [GOC:TermGenie] synonym: "upregulation of protein uptake" EXACT [GOC:TermGenie] is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1904589 ! regulation of protein import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017038 ! protein import relationship: positively_regulates GO:0017038 ! protein import created_by: sl creation_date: 2015-08-20T21:26:42Z [Term] id: GO:1904592 name: positive regulation of protein refolding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein refolding." [GO_REF:0000058, GOC:TermGenie, PMID:11360998] synonym: "activation of heat shock protein activity" RELATED [GOC:TermGenie] synonym: "activation of protein refolding" NARROW [GOC:TermGenie] synonym: "positive regulation of heat shock protein activity" RELATED [GOC:TermGenie] synonym: "up regulation of heat shock protein activity" RELATED [GOC:TermGenie] synonym: "up regulation of protein refolding" EXACT [GOC:TermGenie] synonym: "up-regulation of heat shock protein activity" RELATED [GOC:TermGenie] synonym: "up-regulation of protein refolding" EXACT [GOC:TermGenie] synonym: "upregulation of heat shock protein activity" RELATED [GOC:TermGenie] synonym: "upregulation of protein refolding" EXACT [GOC:TermGenie] is_a: GO:0061083 ! regulation of protein refolding is_a: GO:1903334 ! positive regulation of protein folding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042026 ! protein refolding relationship: positively_regulates GO:0042026 ! protein refolding created_by: sl creation_date: 2015-08-21T18:11:16Z [Term] id: GO:1904593 name: prostaglandin binding namespace: molecular_function def: "Interacting selectively and non-covalently with prostaglandin." [GO_REF:0000067, GOC:TermGenie, PMID:21445266] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050542 ! icosanoid binding created_by: sl creation_date: 2015-08-21T18:53:31Z [Term] id: GO:1904594 name: regulation of termination of RNA polymerase II transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108] synonym: "regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] synonym: "regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] synonym: "regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0031554 ! regulation of DNA-templated transcription, termination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006369 ! termination of RNA polymerase II transcription relationship: regulates GO:0006369 ! termination of RNA polymerase II transcription created_by: al creation_date: 2015-08-25T08:56:06Z [Term] id: GO:1904595 name: positive regulation of termination of RNA polymerase II transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108] synonym: "activation of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:TermGenie] synonym: "activation of RNA polymerase II transcription termination" NARROW [GOC:TermGenie] synonym: "activation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "activation of termination of RNA polymerase II transcription" NARROW [GOC:TermGenie] synonym: "activation of transcription termination from Pol II promoter" NARROW [GOC:TermGenie] synonym: "activation of transcription termination from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] synonym: "up regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "up regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] synonym: "up regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "up-regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] synonym: "upregulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] synonym: "upregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] synonym: "upregulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] synonym: "upregulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription relationship: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription created_by: al creation_date: 2015-08-25T08:56:14Z [Term] id: GO:1904596 name: regulation of connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] synonym: "regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0061041 ! regulation of wound healing is_a: GO:0106014 ! regulation of inflammatory response to wounding is_a: GO:1905203 ! regulation of connective tissue replacement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing relationship: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing created_by: krc creation_date: 2015-08-25T20:52:24Z [Term] id: GO:1904597 name: negative regulation of connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] synonym: "down regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "down regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "down regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "down-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "down-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "down-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "downregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "downregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "downregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "inhibition of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "inhibition of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie] synonym: "inhibition of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "negative regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "negative regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:0106015 ! negative regulation of inflammatory response to wounding is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing is_a: GO:1905204 ! negative regulation of connective tissue replacement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing relationship: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing created_by: krc creation_date: 2015-08-25T20:52:30Z [Term] id: GO:1904598 name: positive regulation of connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] synonym: "activation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "activation of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie] synonym: "activation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "positive regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "positive regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "up regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "up regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "up regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "up-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "up-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "up-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] synonym: "upregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] synonym: "upregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] synonym: "upregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:0106016 ! positive regulation of inflammatory response to wounding is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing is_a: GO:1905205 ! positive regulation of connective tissue replacement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing relationship: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing created_by: krc creation_date: 2015-08-25T20:52:36Z [Term] id: GO:1904599 name: advanced glycation end-product binding namespace: molecular_function def: "Interacting selectively and non-covalently with advanced glycation end-product." [GO_REF:0000067, GOC:krc, GOC:TermGenie, PMID:1650387] is_a: GO:0097367 ! carbohydrate derivative binding created_by: krc creation_date: 2015-08-25T23:39:32Z [Term] id: GO:1904600 name: actin fusion focus assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus." [GO_REF:0000079, GOC:TermGenie, PMID:25825517] synonym: "actin fusion focus formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030036 ! actin cytoskeleton organization created_by: al creation_date: 2015-08-26T10:34:48Z [Term] id: GO:1904601 name: protein localization to actin fusion focus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an actin fusion focus." [GO_REF:0000087, GOC:TermGenie, PMID:25825517] synonym: "protein localisation in actin fusion focus" EXACT [GOC:TermGenie] synonym: "protein localisation to actin fusion focus" EXACT [GOC:TermGenie] synonym: "protein localization in actin fusion focus" EXACT [GOC:TermGenie] is_a: GO:1903119 ! protein localization to actin cytoskeleton is_a: GO:1903260 ! protein localization to mating projection tip created_by: al creation_date: 2015-08-26T10:36:22Z [Term] id: GO:1904602 name: serotonin-activated cation-selective channel complex namespace: cellular_component def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay). synonym: "5-HT-3 receptor complex" EXACT [] synonym: "5-HT3 receptor complex" EXACT [] synonym: "5-hydroxytryptamine receptor 3 complex" EXACT [] synonym: "5HT3 receptor complex" EXACT [] synonym: "serotonin receptor complex" BROAD [] is_a: GO:0034703 ! cation channel complex is_a: GO:0098878 ! neurotransmitter receptor complex created_by: bhm creation_date: 2015-08-26T13:19:49Z [Term] id: GO:1904603 name: regulation of advanced glycation end-product receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] synonym: "regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "regulation of RAGE activity" EXACT [GOC:TermGenie] is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050785 ! advanced glycation end-product receptor activity relationship: regulates GO:0050785 ! advanced glycation end-product receptor activity created_by: krc creation_date: 2015-08-26T16:24:49Z [Term] id: GO:1904604 name: negative regulation of advanced glycation end-product receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] synonym: "down regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "down-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "downregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "inhibition of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie] synonym: "inhibition of AGE receptor activity" NARROW [GOC:TermGenie] synonym: "inhibition of RAGE activity" NARROW [GOC:TermGenie] synonym: "negative regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of RAGE activity" EXACT [GOC:TermGenie] is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity is_a: GO:2000272 ! negative regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050785 ! advanced glycation end-product receptor activity relationship: negatively_regulates GO:0050785 ! advanced glycation end-product receptor activity created_by: krc creation_date: 2015-08-26T16:24:56Z [Term] id: GO:1904605 name: positive regulation of advanced glycation end-product receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] synonym: "activation of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie] synonym: "activation of AGE receptor activity" NARROW [GOC:TermGenie] synonym: "activation of RAGE activity" NARROW [GOC:TermGenie] synonym: "positive regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "up regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "up-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RAGE activity" EXACT [GOC:TermGenie] synonym: "upregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of AGE receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of RAGE activity" EXACT [GOC:TermGenie] is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity is_a: GO:2000273 ! positive regulation of signaling receptor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050785 ! advanced glycation end-product receptor activity relationship: positively_regulates GO:0050785 ! advanced glycation end-product receptor activity created_by: krc creation_date: 2015-08-26T16:25:02Z [Term] id: GO:1904606 name: fat cell apoptotic process namespace: biological_process def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416] synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process created_by: sl creation_date: 2015-08-27T18:13:06Z [Term] id: GO:1904608 name: response to monosodium L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115] is_a: GO:1904008 ! response to monosodium glutamate created_by: sl creation_date: 2015-08-27T18:43:08Z [Term] id: GO:1904609 name: cellular response to monosodium L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115] is_a: GO:1904009 ! cellular response to monosodium glutamate is_a: GO:1904608 ! response to monosodium L-glutamate created_by: sl creation_date: 2015-08-27T18:43:14Z [Term] id: GO:1904610 name: response to 3,3',4,4',5-pentachlorobiphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "response to PCB 126" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2015-08-27T18:52:49Z [Term] id: GO:1904611 name: cellular response to 3,3',4,4',5-pentachlorobiphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "cellular response to PCB 126" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl created_by: sl creation_date: 2015-08-27T18:52:55Z [Term] id: GO:1904612 name: response to 2,3,7,8-tetrachlorodibenzodioxine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "response to dioxin" EXACT [] synonym: "response to TCDD" EXACT [] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound created_by: sl creation_date: 2015-08-27T19:01:52Z [Term] id: GO:1904613 name: cellular response to 2,3,7,8-tetrachlorodibenzodioxine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "cellular response to dioxin" EXACT [] synonym: "cellular response to TCDD" EXACT [] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine created_by: sl creation_date: 2015-08-27T19:01:58Z [Term] id: GO:1904614 name: response to biphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0060992 ! response to fungicide created_by: sl creation_date: 2015-08-27T19:08:43Z [Term] id: GO:1904615 name: cellular response to biphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904614 ! response to biphenyl created_by: sl creation_date: 2015-08-27T19:08:49Z [Term] id: GO:1904616 name: regulation of actin binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "regulation of membrane associated actin binding" NARROW [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003779 ! actin binding relationship: regulates GO:0003779 ! actin binding created_by: mr creation_date: 2015-08-27T19:08:56Z [Term] id: GO:1904617 name: negative regulation of actin binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "down regulation of actin binding" EXACT [GOC:TermGenie] synonym: "down regulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "down-regulation of actin binding" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "downregulation of actin binding" EXACT [GOC:TermGenie] synonym: "downregulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "inhibition of actin binding" NARROW [GOC:TermGenie] synonym: "inhibition of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "negative regulation of membrane associated actin binding" NARROW [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1904616 ! regulation of actin binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003779 ! actin binding relationship: negatively_regulates GO:0003779 ! actin binding created_by: mr creation_date: 2015-08-27T19:09:02Z [Term] id: GO:1904618 name: positive regulation of actin binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "activation of actin binding" NARROW [GOC:TermGenie] synonym: "activation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "positive regulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "up regulation of actin binding" EXACT [GOC:TermGenie] synonym: "up regulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "up-regulation of actin binding" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane associated actin binding" NARROW [GOC:TermGenie] synonym: "upregulation of actin binding" EXACT [GOC:TermGenie] synonym: "upregulation of membrane associated actin binding" NARROW [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1904616 ! regulation of actin binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003779 ! actin binding relationship: positively_regulates GO:0003779 ! actin binding created_by: mr creation_date: 2015-08-27T19:09:08Z [Term] id: GO:1904619 name: response to dimethyl sulfoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] synonym: "response to DMSO" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2015-08-27T19:13:49Z [Term] id: GO:1904620 name: cellular response to dimethyl sulfoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] synonym: "cellular response to DMSO" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:1904619 ! response to dimethyl sulfoxide created_by: sl creation_date: 2015-08-27T19:14:07Z [Term] id: GO:1904621 name: regulation of actin-dependent ATPase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0043462 ! regulation of ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030898 ! actin-dependent ATPase activity relationship: regulates GO:0030898 ! actin-dependent ATPase activity created_by: mr creation_date: 2015-08-27T19:37:18Z [Term] id: GO:1904622 name: negative regulation of actin-dependent ATPase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "down regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "inhibition of actin-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of actin-dependent ATPase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:1904621 ! regulation of actin-dependent ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030898 ! actin-dependent ATPase activity relationship: negatively_regulates GO:0030898 ! actin-dependent ATPase activity created_by: mr creation_date: 2015-08-27T19:37:24Z [Term] id: GO:1904623 name: positive regulation of actin-dependent ATPase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin-dependent ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] synonym: "activation of actin-activated ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of actin-dependent ATPase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of actin-activated ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:1904621 ! regulation of actin-dependent ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030898 ! actin-dependent ATPase activity relationship: positively_regulates GO:0030898 ! actin-dependent ATPase activity created_by: mr creation_date: 2015-08-27T19:37:30Z [Term] id: GO:1904624 name: regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061537 ! glycine secretion, neurotransmission relationship: regulates GO:0061537 ! glycine secretion, neurotransmission created_by: hjd creation_date: 2015-08-27T20:03:38Z [Term] id: GO:1904625 name: negative regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission created_by: hjd creation_date: 2015-08-27T20:03:44Z [Term] id: GO:1904626 name: positive regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061537 ! glycine secretion, neurotransmission relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission created_by: hjd creation_date: 2015-08-27T20:03:49Z [Term] id: GO:1904627 name: response to phorbol 13-acetate 12-myristate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903] synonym: "response to phorbol 12-tetradecanoate 13-acetate" EXACT [] synonym: "response to PMA" EXACT [] synonym: "response to tetradecanoylphorbol acetate" EXACT [] synonym: "response to TPA" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-28T13:44:03Z [Term] id: GO:1904628 name: cellular response to phorbol 13-acetate 12-myristate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903] synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT [] synonym: "cellular response to response to PMA" EXACT [] synonym: "cellular response to tetradecanoylphorbol acetate" EXACT [] synonym: "cellular response to TPA" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904627 ! response to phorbol 13-acetate 12-myristate created_by: sl creation_date: 2015-08-28T13:44:10Z [Term] id: GO:1904629 name: response to diterpene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580] is_a: GO:0033993 ! response to lipid created_by: sl creation_date: 2015-08-28T13:52:37Z [Term] id: GO:1904630 name: cellular response to diterpene namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1904629 ! response to diterpene created_by: sl creation_date: 2015-08-28T13:52:43Z [Term] id: GO:1904631 name: response to glucoside namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873] synonym: "response to glucosides" EXACT [] is_a: GO:1903416 ! response to glycoside created_by: sl creation_date: 2015-08-28T14:01:31Z [Term] id: GO:1904632 name: cellular response to glucoside namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873] synonym: "cellular response to glucosides" EXACT [] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904631 ! response to glucoside created_by: sl creation_date: 2015-08-28T14:01:37Z [Term] id: GO:1904633 name: regulation of glomerular visceral epithelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process relationship: regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process created_by: sl creation_date: 2015-08-28T14:14:44Z [Term] id: GO:1904634 name: negative regulation of glomerular visceral epithelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "down regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process relationship: negatively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process created_by: sl creation_date: 2015-08-28T14:14:50Z [Term] id: GO:1904635 name: positive regulation of glomerular visceral epithelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] synonym: "activation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of podocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of podocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process relationship: positively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process created_by: sl creation_date: 2015-08-28T14:14:56Z [Term] id: GO:1904636 name: response to ionomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0070542 ! response to fatty acid created_by: sl creation_date: 2015-08-31T14:39:18Z [Term] id: GO:1904637 name: cellular response to ionomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843] is_a: GO:0071362 ! cellular response to ether is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1904636 ! response to ionomycin created_by: sl creation_date: 2015-08-31T14:39:25Z [Term] id: GO:1904638 name: response to resveratrol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] is_a: GO:0009636 ! response to toxic substance is_a: GO:0035634 ! response to stilbenoid is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-08-31T17:07:38Z [Term] id: GO:1904639 name: cellular response to resveratrol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904638 ! response to resveratrol created_by: sl creation_date: 2015-08-31T17:07:44Z [Term] id: GO:1904640 name: response to methionine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17716000] is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2015-08-31T17:23:56Z [Term] id: GO:1904641 name: response to dinitrophenol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883] synonym: "response to dinitrophenols" RELATED [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-08-31T20:13:12Z [Term] id: GO:1904642 name: cellular response to dinitrophenol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883] synonym: "cellular response to dinitrophenols" RELATED [] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904641 ! response to dinitrophenol created_by: sl creation_date: 2015-08-31T20:13:18Z [Term] id: GO:1904643 name: response to curcumin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-31T20:38:11Z [Term] id: GO:1904644 name: cellular response to curcumin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904643 ! response to curcumin created_by: sl creation_date: 2015-08-31T20:38:17Z [Term] id: GO:1904645 name: response to amyloid-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] synonym: "response to beta-amyloid" EXACT [] synonym: "response to beta-amyloids" RELATED [] is_a: GO:1901652 ! response to peptide created_by: sl creation_date: 2015-08-31T20:44:43Z [Term] id: GO:1904646 name: cellular response to amyloid-beta namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] synonym: "cellular response to beta-amyloid" EXACT [] synonym: "cellular response to beta-amyloids" RELATED [] is_a: GO:1901653 ! cellular response to peptide is_a: GO:1904645 ! response to amyloid-beta created_by: sl creation_date: 2015-08-31T20:44:49Z [Term] id: GO:1904647 name: response to rotenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0017085 ! response to insecticide is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-31T20:55:32Z [Term] id: GO:1904648 name: cellular response to rotenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904647 ! response to rotenone created_by: sl creation_date: 2015-08-31T20:55:39Z [Term] id: GO:1904649 name: regulation of fat cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904606 ! fat cell apoptotic process relationship: regulates GO:1904606 ! fat cell apoptotic process created_by: sl creation_date: 2015-08-31T20:59:28Z [Term] id: GO:1904650 name: negative regulation of fat cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904606 ! fat cell apoptotic process relationship: negatively_regulates GO:1904606 ! fat cell apoptotic process created_by: sl creation_date: 2015-08-31T20:59:34Z [Term] id: GO:1904651 name: positive regulation of fat cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904606 ! fat cell apoptotic process relationship: positively_regulates GO:1904606 ! fat cell apoptotic process created_by: sl creation_date: 2015-08-31T20:59:40Z [Term] id: GO:1904652 name: protein localization to cell division site involved in cell separation after cytokinesis namespace: biological_process def: "Any protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334] is_a: GO:0072741 ! protein localization to cell division site intersection_of: GO:0072741 ! protein localization to cell division site intersection_of: part_of GO:0000920 ! septum digestion after cytokinesis relationship: part_of GO:0000920 ! septum digestion after cytokinesis created_by: vw creation_date: 2015-09-01T21:04:45Z [Term] id: GO:1904653 name: regulation of lung alveolus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "regulation of alveologenesis" EXACT [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048286 ! lung alveolus development relationship: regulates GO:0048286 ! lung alveolus development created_by: sl creation_date: 2015-09-03T22:44:44Z [Term] id: GO:1904654 name: negative regulation of lung alveolus development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "down regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "down regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "down regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "down-regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "downregulation of alveolarization" EXACT [GOC:TermGenie] synonym: "downregulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "downregulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "inhibition of alveolarization" NARROW [GOC:TermGenie] synonym: "inhibition of alveologenesis" NARROW [GOC:TermGenie] synonym: "inhibition of lung alveolus development" NARROW [GOC:TermGenie] synonym: "negative regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "negative regulation of alveologenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904653 ! regulation of lung alveolus development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048286 ! lung alveolus development relationship: negatively_regulates GO:0048286 ! lung alveolus development created_by: sl creation_date: 2015-09-03T22:44:50Z [Term] id: GO:1904655 name: positive regulation of lung alveolus development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] synonym: "activation of alveolarization" NARROW [GOC:TermGenie] synonym: "activation of alveologenesis" NARROW [GOC:TermGenie] synonym: "activation of lung alveolus development" NARROW [GOC:TermGenie] synonym: "positive regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "positive regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "up regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "up-regulation of alveolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of lung alveolus development" EXACT [GOC:TermGenie] synonym: "upregulation of alveolarization" EXACT [GOC:TermGenie] synonym: "upregulation of alveologenesis" EXACT [GOC:TermGenie] synonym: "upregulation of lung alveolus development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904653 ! regulation of lung alveolus development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048286 ! lung alveolus development relationship: positively_regulates GO:0048286 ! lung alveolus development created_by: sl creation_date: 2015-09-03T22:44:56Z [Term] id: GO:1904656 name: regulation of sensory perception of sweet taste namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "regulation of sweet taste perception" EXACT [GOC:TermGenie] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050916 ! sensory perception of sweet taste relationship: regulates GO:0050916 ! sensory perception of sweet taste created_by: mr creation_date: 2015-09-04T16:43:12Z [Term] id: GO:1904657 name: negative regulation of sensory perception of sweet taste namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "down regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "down regulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "down-regulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "downregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "downregulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "inhibition of sensory perception of sweet taste" NARROW [GOC:TermGenie] synonym: "inhibition of sweet taste perception" NARROW [GOC:TermGenie] synonym: "negative regulation of sweet taste perception" EXACT [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:1904656 ! regulation of sensory perception of sweet taste intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050916 ! sensory perception of sweet taste relationship: negatively_regulates GO:0050916 ! sensory perception of sweet taste created_by: mr creation_date: 2015-09-04T16:43:18Z [Term] id: GO:1904658 name: positive regulation of sensory perception of sweet taste namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "activation of sensory perception of sweet taste" NARROW [GOC:TermGenie] synonym: "activation of sweet taste perception" NARROW [GOC:TermGenie] synonym: "positive regulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "up regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "up regulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "up-regulation of sweet taste perception" EXACT [GOC:TermGenie] synonym: "upregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] synonym: "upregulation of sweet taste perception" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:1904656 ! regulation of sensory perception of sweet taste intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050916 ! sensory perception of sweet taste relationship: positively_regulates GO:0050916 ! sensory perception of sweet taste created_by: mr creation_date: 2015-09-04T16:43:24Z [Term] id: GO:1904659 name: glucose transmembrane transport namespace: biological_process alt_id: GO:0015758 def: "The process in which glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] synonym: "glucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport created_by: vw creation_date: 2015-09-04T17:20:16Z [Term] id: GO:1904660 name: regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "regulation of bitter taste perception" EXACT [GOC:TermGenie] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050913 ! sensory perception of bitter taste relationship: regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:10Z [Term] id: GO:1904661 name: negative regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "down regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "down regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "down-regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "downregulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "downregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "inhibition of bitter taste perception" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of bitter taste" NARROW [GOC:TermGenie] synonym: "negative regulation of bitter taste perception" EXACT [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:1904660 ! regulation of sensory perception of bitter taste intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050913 ! sensory perception of bitter taste relationship: negatively_regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:17Z [Term] id: GO:1904662 name: positive regulation of sensory perception of bitter taste namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] synonym: "activation of bitter taste perception" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of bitter taste" NARROW [GOC:TermGenie] synonym: "positive regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "up-regulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] synonym: "upregulation of bitter taste perception" EXACT [GOC:TermGenie] synonym: "upregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:1904660 ! regulation of sensory perception of bitter taste intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050913 ! sensory perception of bitter taste relationship: positively_regulates GO:0050913 ! sensory perception of bitter taste created_by: mr creation_date: 2015-09-04T17:54:22Z [Term] id: GO:1904663 name: regulation of N-terminal peptidyl-methionine acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] is_a: GO:1901983 ! regulation of protein acetylation is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation relationship: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation created_by: vw creation_date: 2015-09-07T19:18:49Z [Term] id: GO:1904664 name: negative regulation of N-terminal peptidyl-methionine acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] is_a: GO:1901984 ! negative regulation of protein acetylation is_a: GO:1903318 ! negative regulation of protein maturation is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation relationship: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation created_by: vw creation_date: 2015-09-07T19:18:56Z [Term] id: GO:1904665 name: positive regulation of N-terminal peptidyl-methionine acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] is_a: GO:1901985 ! positive regulation of protein acetylation is_a: GO:1903319 ! positive regulation of protein maturation is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation relationship: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation created_by: vw creation_date: 2015-09-07T19:19:02Z [Term] id: GO:1904666 name: regulation of ubiquitin protein ligase activity namespace: biological_process alt_id: GO:1903834 def: "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] synonym: "regulation of APC-fizzy related complex activity" NARROW [] synonym: "regulation of E3" RELATED [GOC:TermGenie] synonym: "regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061630 ! ubiquitin protein ligase activity relationship: regulates GO:0061630 ! ubiquitin protein ligase activity created_by: dph creation_date: 2015-09-08T15:26:59Z [Term] id: GO:1904667 name: negative regulation of ubiquitin protein ligase activity namespace: biological_process alt_id: GO:0060564 alt_id: GO:1904190 def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] synonym: "down regulation of E3" RELATED [GOC:TermGenie] synonym: "down regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of E3" RELATED [GOC:TermGenie] synonym: "down-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of E3" RELATED [GOC:TermGenie] synonym: "downregulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] synonym: "inhibition of E3" RELATED [GOC:TermGenie] synonym: "inhibition of protein ubiquitination activity" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquitin ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquitin protein ligase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of anaphase-promoting complex activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of APC-Cdc20 complex activity" NARROW [] synonym: "negative regulation of APC-fizzy related complex activity" NARROW [] synonym: "negative regulation of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of E3" RELATED [GOC:TermGenie] synonym: "negative regulation of mitotic anaphase-promoting complex activity" RELATED [GOC:vw] synonym: "negative regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061630 ! ubiquitin protein ligase activity relationship: negatively_regulates GO:0061630 ! ubiquitin protein ligase activity created_by: dph creation_date: 2015-09-08T15:27:05Z [Term] id: GO:1904668 name: positive regulation of ubiquitin protein ligase activity namespace: biological_process alt_id: GO:0007092 alt_id: GO:0051488 alt_id: GO:0090623 alt_id: GO:1903835 def: "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] synonym: "activation of anaphase-promoting complex activity" NARROW [] synonym: "activation of APC-Cdc20 complex activity" NARROW [] synonym: "activation of APC-fizzy related complex activity" NARROW [] synonym: "activation of E3" RELATED [GOC:TermGenie] synonym: "activation of protein ubiquitination activity" NARROW [GOC:TermGenie] synonym: "activation of ubiquitin ligase activity" NARROW [GOC:TermGenie] synonym: "activation of ubiquitin protein ligase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of APC-fizzy related complex activity" NARROW [] synonym: "positive regulation of E3" RELATED [GOC:TermGenie] synonym: "positive regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ubiquitin ligase activity" RELATED [GOC:TermGenie] synonym: "up regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] synonym: "up regulation of E3" RELATED [GOC:TermGenie] synonym: "up regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] synonym: "up-regulation of E3" RELATED [GOC:TermGenie] synonym: "up-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] synonym: "upregulation of E3" RELATED [GOC:TermGenie] synonym: "upregulation of protein ubiquitination activity" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061630 ! ubiquitin protein ligase activity relationship: positively_regulates GO:0061630 ! ubiquitin protein ligase activity created_by: dph creation_date: 2015-09-08T15:27:11Z [Term] id: GO:1904669 name: ATP export namespace: biological_process def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344] synonym: "ATP efflux" RELATED [] is_a: GO:0015867 ! ATP transport is_a: GO:0046618 ! drug export created_by: tb creation_date: 2015-09-09T16:33:06Z [Term] id: GO:1904670 name: actin filament polymerization involved in mitotic actomyosin contractile ring assembly namespace: biological_process def: "Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:TermGenie, PMID:24127216] is_a: GO:0030041 ! actin filament polymerization is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization intersection_of: GO:0030041 ! actin filament polymerization intersection_of: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2015-09-09T20:05:56Z [Term] id: GO:1904671 name: negative regulation of cell differentiation involved in stem cell population maintenance namespace: biological_process def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] {comment="GOC:BHF"} synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie] synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0045596 ! negative regulation of cell differentiation intersection_of: part_of GO:0019827 ! stem cell population maintenance relationship: part_of GO:0019827 ! stem cell population maintenance created_by: tb creation_date: 2015-09-12T00:46:08Z [Term] id: GO:1904672 name: regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] is_a: GO:2000036 ! regulation of stem cell population maintenance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035019 ! somatic stem cell population maintenance relationship: regulates GO:0035019 ! somatic stem cell population maintenance created_by: rph creation_date: 2015-09-14T08:40:19Z [Term] id: GO:1904673 name: negative regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie] is_a: GO:1902455 ! negative regulation of stem cell population maintenance is_a: GO:1904672 ! regulation of somatic stem cell population maintenance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035019 ! somatic stem cell population maintenance relationship: negatively_regulates GO:0035019 ! somatic stem cell population maintenance created_by: rph creation_date: 2015-09-14T08:40:25Z [Term] id: GO:1904674 name: positive regulation of somatic stem cell population maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie] synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] is_a: GO:1902459 ! positive regulation of stem cell population maintenance is_a: GO:1904672 ! regulation of somatic stem cell population maintenance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035019 ! somatic stem cell population maintenance relationship: positively_regulates GO:0035019 ! somatic stem cell population maintenance created_by: rph creation_date: 2015-09-14T08:40:32Z [Term] id: GO:1904675 name: regulation of somatic stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048103 ! somatic stem cell division relationship: regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:22Z [Term] id: GO:1904676 name: negative regulation of somatic stem cell division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048103 ! somatic stem cell division relationship: negatively_regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:28Z [Term] id: GO:1904677 name: positive regulation of somatic stem cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048103 ! somatic stem cell division relationship: positively_regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:34Z [Term] id: GO:1904678 name: alpha-aminoacyl-tRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with alpha-aminoacyl-tRNA." [GO_REF:0000067, GOC:TermGenie, ISBN:155581073X] synonym: "aminoacyl-tRNA binding" RELATED [] is_a: GO:0003723 ! RNA binding created_by: hjd creation_date: 2015-09-18T16:44:17Z [Term] id: GO:1904679 name: myo-inositol import across plasma membrane namespace: biological_process alt_id: GO:0097357 def: "The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:9560432] synonym: "myo-inositol import into cell" EXACT [] is_a: GO:0015798 ! myo-inositol transport is_a: GO:0098739 ! import across plasma membrane created_by: al creation_date: 2012-07-03T06:22:05Z [Term] id: GO:1904680 name: peptide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015197 alt_id: GO:0015637 def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] synonym: "peptide transporter activity" RELATED [] synonym: "peptide uptake permease activity" RELATED [] xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" is_a: GO:0042887 ! amide transmembrane transporter activity created_by: tb creation_date: 2015-09-22T18:50:41Z [Term] id: GO:1904681 name: response to 3-methylcholanthrene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771] is_a: GO:1903165 ! response to polycyclic arene created_by: mr creation_date: 2015-09-22T19:50:03Z [Term] id: GO:1904682 name: cellular response to 3-methylcholanthrene namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771] is_a: GO:1903166 ! cellular response to polycyclic arene is_a: GO:1904681 ! response to 3-methylcholanthrene created_by: mr creation_date: 2015-09-22T19:50:10Z [Term] id: GO:1904683 name: regulation of metalloendopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] synonym: "regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0052548 ! regulation of endopeptidase activity is_a: GO:1905048 ! regulation of metallopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004222 ! metalloendopeptidase activity relationship: regulates GO:0004222 ! metalloendopeptidase activity created_by: rph creation_date: 2015-09-24T11:18:14Z [Term] id: GO:1904684 name: negative regulation of metalloendopeptidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] synonym: "down regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "down regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "down-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "downregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendopeptidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "inhibition of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of metalloendoprotease activity" EXACT [GOC:TermGenie] synonym: "negative regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:1904683 ! regulation of metalloendopeptidase activity is_a: GO:1905049 ! negative regulation of metallopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004222 ! metalloendopeptidase activity relationship: negatively_regulates GO:0004222 ! metalloendopeptidase activity created_by: rph creation_date: 2015-09-24T11:18:21Z [Term] id: GO:1904685 name: positive regulation of metalloendopeptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] synonym: "activation of metalloendopeptidase activity" NARROW [GOC:TermGenie] synonym: "activation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "activation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "positive regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "up regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "up-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of metalloendoprotease activity" NARROW [GOC:TermGenie] synonym: "upregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0010950 ! positive regulation of endopeptidase activity is_a: GO:1904683 ! regulation of metalloendopeptidase activity is_a: GO:1905050 ! positive regulation of metallopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004222 ! metalloendopeptidase activity relationship: positively_regulates GO:0004222 ! metalloendopeptidase activity created_by: rph creation_date: 2015-09-24T11:18:28Z [Term] id: GO:1904686 name: regulation of mitotic spindle disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819] synonym: "regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] synonym: "regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] synonym: "regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] synonym: "regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] synonym: "regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] synonym: "regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] is_a: GO:0060236 ! regulation of mitotic spindle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051228 ! mitotic spindle disassembly relationship: regulates GO:0051228 ! mitotic spindle disassembly created_by: al creation_date: 2015-09-24T14:20:07Z [Term] id: GO:1904687 name: positive regulation of mitotic spindle disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819] synonym: "activation of mitotic spindle breakdown" NARROW [GOC:TermGenie] synonym: "activation of mitotic spindle catabolism" NARROW [GOC:TermGenie] synonym: "activation of mitotic spindle degradation" NARROW [GOC:TermGenie] synonym: "activation of mitotic spindle disassembly" NARROW [GOC:TermGenie] synonym: "activation of spindle breakdown during mitosis" NARROW [GOC:TermGenie] synonym: "activation of spindle degradation during mitosis" NARROW [GOC:TermGenie] synonym: "activation of spindle disassembly during mitosis" NARROW [GOC:TermGenie] synonym: "positive regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] is_a: GO:0110028 ! positive regulation of mitotic spindle organization is_a: GO:1904686 ! regulation of mitotic spindle disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051228 ! mitotic spindle disassembly relationship: positively_regulates GO:0051228 ! mitotic spindle disassembly created_by: al creation_date: 2015-09-24T14:20:13Z [Term] id: GO:1904688 name: regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002183 ! cytoplasmic translational initiation relationship: regulates GO:0002183 ! cytoplasmic translational initiation created_by: dos creation_date: 2015-09-25T14:39:38Z [Term] id: GO:1904689 name: negative regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation is_a: GO:2000766 ! negative regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002183 ! cytoplasmic translational initiation relationship: negatively_regulates GO:0002183 ! cytoplasmic translational initiation created_by: dos creation_date: 2015-09-25T14:39:44Z [Term] id: GO:1904690 name: positive regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation is_a: GO:2000767 ! positive regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002183 ! cytoplasmic translational initiation relationship: positively_regulates GO:0002183 ! cytoplasmic translational initiation created_by: dos creation_date: 2015-09-25T14:39:50Z [Term] id: GO:1904691 name: negative regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation relationship: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation created_by: sl creation_date: 2015-09-25T15:23:38Z [Term] id: GO:1904692 name: positive regulation of type B pancreatic cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044342 ! type B pancreatic cell proliferation relationship: positively_regulates GO:0044342 ! type B pancreatic cell proliferation created_by: sl creation_date: 2015-09-25T15:23:44Z [Term] id: GO:1904693 name: midbrain morphogenesis namespace: biological_process def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "MB morphogenesis" BROAD [GOC:TermGenie] synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030901 ! midbrain development relationship: part_of GO:0048854 ! brain morphogenesis created_by: bf creation_date: 2015-09-29T09:15:28Z [Term] id: GO:1904694 name: negative regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:0003056 ! regulation of vascular smooth muscle contraction is_a: GO:0045906 ! negative regulation of vasoconstriction is_a: GO:0045986 ! negative regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014829 ! vascular smooth muscle contraction relationship: negatively_regulates GO:0014829 ! vascular smooth muscle contraction created_by: rph creation_date: 2015-09-29T13:39:08Z [Term] id: GO:1904695 name: positive regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:0003056 ! regulation of vascular smooth muscle contraction is_a: GO:0045907 ! positive regulation of vasoconstriction is_a: GO:0045987 ! positive regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014829 ! vascular smooth muscle contraction relationship: positively_regulates GO:0014829 ! vascular smooth muscle contraction created_by: rph creation_date: 2015-09-29T13:39:14Z [Term] id: GO:1904697 name: regulation of acinar cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990863 ! acinar cell proliferation relationship: regulates GO:1990863 ! acinar cell proliferation created_by: sl creation_date: 2015-09-30T15:19:50Z [Term] id: GO:1904698 name: negative regulation of acinar cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990863 ! acinar cell proliferation relationship: negatively_regulates GO:1990863 ! acinar cell proliferation created_by: sl creation_date: 2015-09-30T15:19:57Z [Term] id: GO:1904699 name: positive regulation of acinar cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990863 ! acinar cell proliferation relationship: positively_regulates GO:1990863 ! acinar cell proliferation created_by: sl creation_date: 2015-09-30T15:20:03Z [Term] id: GO:1904700 name: granulosa cell apoptotic process namespace: biological_process def: "Any apoptotic process in a granulosa cell." [GO_REF:0000085, GOC:TermGenie, PMID:19208546] synonym: "granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2015-09-30T21:29:54Z [Term] id: GO:1904701 name: Wnt-Frizzled-LRP5/6 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11448771] synonym: "Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] synonym: "Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "Wnt receptor complex assembly" BROAD [GOC:bf] synonym: "WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: bf creation_date: 2015-10-01T09:37:57Z [Term] id: GO:1904702 name: regulation of protein localization to adherens junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] synonym: "regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0071896 ! protein localization to adherens junction relationship: regulates GO:0071896 ! protein localization to adherens junction created_by: kmv creation_date: 2015-10-01T15:11:49Z [Term] id: GO:1904703 name: negative regulation of protein localization to adherens junction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] synonym: "down regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] is_a: GO:0150119 ! negative regulation of protein localization to cell-cell junction is_a: GO:1904702 ! regulation of protein localization to adherens junction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0071896 ! protein localization to adherens junction relationship: negatively_regulates GO:0071896 ! protein localization to adherens junction created_by: kmv creation_date: 2015-10-01T15:11:56Z [Term] id: GO:1904704 name: positive regulation of protein localization to adherens junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] synonym: "activation of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] is_a: GO:0150107 ! positive regulation of protein localization to cell-cell junction is_a: GO:1904702 ! regulation of protein localization to adherens junction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0071896 ! protein localization to adherens junction relationship: positively_regulates GO:0071896 ! protein localization to adherens junction created_by: kmv creation_date: 2015-10-01T15:12:02Z [Term] id: GO:1904705 name: regulation of vascular smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990874 ! vascular smooth muscle cell proliferation relationship: regulates GO:1990874 ! vascular smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:20Z [Term] id: GO:1904706 name: negative regulation of vascular smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation relationship: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:26Z [Term] id: GO:1904707 name: positive regulation of vascular smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation relationship: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:32Z [Term] id: GO:1904708 name: regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904700 ! granulosa cell apoptotic process relationship: regulates GO:1904700 ! granulosa cell apoptotic process created_by: sl creation_date: 2015-10-01T16:09:38Z [Term] id: GO:1904709 name: negative regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "down regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1904708 ! regulation of granulosa cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904700 ! granulosa cell apoptotic process relationship: negatively_regulates GO:1904700 ! granulosa cell apoptotic process created_by: sl creation_date: 2015-10-01T16:09:45Z [Term] id: GO:1904710 name: positive regulation of granulosa cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] synonym: "activation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "activation of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1904708 ! regulation of granulosa cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904700 ! granulosa cell apoptotic process relationship: positively_regulates GO:1904700 ! granulosa cell apoptotic process created_by: sl creation_date: 2015-10-01T16:09:51Z [Term] id: GO:1904711 name: regulation of Wnt-Frizzled-LRP5/6 complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] synonym: "regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "regulation of Wnt receptor complex assembly" BROAD [GOC:TermGenie] synonym: "regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly relationship: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly created_by: bf creation_date: 2015-10-05T14:02:22Z [Term] id: GO:1904712 name: positive regulation of Wnt-Frizzled-LRP5/6 complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "activation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie] synonym: "activation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "positive regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] synonym: "positive regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "positive regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "up regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "up regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "up regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "up regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "up-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "up-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "upregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "upregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "upregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "upregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly relationship: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly created_by: bf creation_date: 2015-10-05T14:02:35Z [Term] id: GO:1904713 name: beta-catenin destruction complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-catenin destruction complex." [GO_REF:000102, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650] synonym: "23S APC complex binding" NARROW [GOC:TermGenie] synonym: "APC-Axin-1-beta-catenin complex binding" EXACT [GOC:TermGenie] synonym: "Axin-APC-beta-catenin-GSK3B complex binding" EXACT [GOC:TermGenie] synonym: "BDC binding" EXACT [PMID:22899650] synonym: "beta-catenin degradation complex binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: bf creation_date: 2015-10-05T14:34:14Z [Term] id: GO:1904714 name: regulation of chaperone-mediated autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] synonym: "regulation of CMA" RELATED [GOC:TermGenie] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061684 ! chaperone-mediated autophagy relationship: regulates GO:0061684 ! chaperone-mediated autophagy created_by: pad creation_date: 2015-10-06T08:49:02Z [Term] id: GO:1904715 name: negative regulation of chaperone-mediated autophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] synonym: "down regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "down regulation of CMA" RELATED [GOC:TermGenie] synonym: "down-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "down-regulation of CMA" RELATED [GOC:TermGenie] synonym: "downregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "downregulation of CMA" RELATED [GOC:TermGenie] synonym: "inhibition of chaperone-mediated autophagy" NARROW [GOC:TermGenie] synonym: "inhibition of CMA" RELATED [GOC:TermGenie] synonym: "negative regulation of CMA" RELATED [GOC:TermGenie] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1904714 ! regulation of chaperone-mediated autophagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061684 ! chaperone-mediated autophagy relationship: negatively_regulates GO:0061684 ! chaperone-mediated autophagy created_by: pad creation_date: 2015-10-06T08:49:09Z [Term] id: GO:1904716 name: positive regulation of chaperone-mediated autophagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] synonym: "activation of chaperone-mediated autophagy" NARROW [GOC:TermGenie] synonym: "activation of CMA" RELATED [GOC:TermGenie] synonym: "positive regulation of CMA" RELATED [GOC:TermGenie] synonym: "up regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "up regulation of CMA" RELATED [GOC:TermGenie] synonym: "up-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "up-regulation of CMA" RELATED [GOC:TermGenie] synonym: "upregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] synonym: "upregulation of CMA" RELATED [GOC:TermGenie] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1904714 ! regulation of chaperone-mediated autophagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061684 ! chaperone-mediated autophagy relationship: positively_regulates GO:0061684 ! chaperone-mediated autophagy created_by: pad creation_date: 2015-10-06T08:49:15Z [Term] id: GO:1904717 name: regulation of AMPA glutamate receptor clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] is_a: GO:0106104 ! regulation of glutamate receptor clustering is_a: GO:1901626 ! regulation of postsynaptic membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097113 ! AMPA glutamate receptor clustering relationship: regulates GO:0097113 ! AMPA glutamate receptor clustering created_by: hjd creation_date: 2015-10-07T19:32:11Z [Term] id: GO:1904718 name: negative regulation of AMPA glutamate receptor clustering namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] synonym: "down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "down regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "down regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "down-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "downregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "downregulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie] synonym: "inhibition of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie] synonym: "inhibition of AMPA receptor clustering" NARROW [GOC:TermGenie] synonym: "negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "negative regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization is_a: GO:1903910 ! negative regulation of receptor clustering is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering relationship: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering created_by: hjd creation_date: 2015-10-07T19:32:28Z [Term] id: GO:1904719 name: positive regulation of AMPA glutamate receptor clustering namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] synonym: "activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie] synonym: "activation of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie] synonym: "activation of AMPA receptor clustering" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "positive regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "up regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "up regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "up-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "upregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] synonym: "upregulation of AMPA receptor clustering" EXACT [GOC:TermGenie] is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization is_a: GO:1903911 ! positive regulation of receptor clustering is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering relationship: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering created_by: hjd creation_date: 2015-10-07T19:32:34Z [Term] id: GO:1904720 name: obsolete regulation of mRNA endonucleolytic cleavage involved in unfolded protein response namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063, PMID:20625543] comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. synonym: "regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:1903895 created_by: bf creation_date: 2015-10-08T14:52:49Z [Term] id: GO:1904721 name: obsolete negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063] comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. synonym: "down regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "down regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "down regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "down regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "down regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "down-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "down-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "down-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "down-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "down-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "downregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "downregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "downregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "downregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "downregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "inhibition of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "inhibition of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "inhibition of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "inhibition of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie] synonym: "inhibition of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "negative regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "negative regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "negative regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "negative regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:1903895 created_by: bf creation_date: 2015-10-08T14:52:55Z [Term] id: GO:1904722 name: obsolete positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20625543] comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. synonym: "activation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "activation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "activation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "activation of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie] synonym: "activation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "positive regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "positive regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "positive regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "positive regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "up regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "up regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "up-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "up-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "up-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "upregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "upregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] synonym: "upregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] synonym: "upregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] synonym: "upregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] is_obsolete: true consider: GO:1903896 created_by: bf creation_date: 2015-10-08T14:53:02Z [Term] id: GO:1904723 name: negative regulation of Wnt-Frizzled-LRP5/6 complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302] synonym: "down regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "down regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "down regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "down regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "down-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "down-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "downregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "downregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "downregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "downregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "inhibition of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "inhibition of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "negative regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] synonym: "negative regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] synonym: "negative regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly relationship: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly created_by: bf creation_date: 2015-10-12T08:14:59Z [Term] id: GO:1904724 name: tertiary granule lumen namespace: cellular_component def: "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] synonym: "gelatinase granule membrane-enclosed lumen" RELATED [] synonym: "membrane-enclosed lumen of gelatinase granule" EXACT [GOC:TermGenie] synonym: "membrane-enclosed lumen of tertiary granule" EXACT [GOC:TermGenie] synonym: "tertiary granule membrane-enclosed lumen" EXACT [] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0070820 ! tertiary granule relationship: part_of GO:0070820 ! tertiary granule created_by: mec creation_date: 2015-10-12T12:53:10Z [Term] id: GO:1904725 name: obsolete TFIIB-class transcription factor binding involved in negative regulation of transcription namespace: molecular_function def: "OBSOLETE. Any TFIIB-class transcription factor binding that is involved in negative regulation of DNA-templated transcription." [GO_REF:0000061, GOC:rb, GOC:TermGenie, PMID:12461786] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "TFIIB-class transcription factor binding involved in down regulation of gene-specific transcription" RELATED [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in down regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in down-regulation of gene-specific transcription" RELATED [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in down-regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in downregulation of gene-specific transcription" RELATED [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in downregulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in inhibition of gene-specific transcription" RELATED [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in inhibition of transcription, DNA-dependent" NARROW [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in negative regulation of cellular transcription, DNA-dependent" EXACT [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in negative regulation of gene-specific transcription" RELATED [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-templated" EXACT [] synonym: "TFIIB-class transcription factor binding involved in transcription repressor activity" RELATED [GOC:TermGenie] is_obsolete: true created_by: tb creation_date: 2015-10-13T19:49:39Z [Term] id: GO:1904726 name: regulation of replicative senescence namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] is_a: GO:0090342 ! regulation of cell aging intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090399 ! replicative senescence relationship: regulates GO:0090399 ! replicative senescence created_by: rph creation_date: 2015-10-14T13:11:24Z [Term] id: GO:1904727 name: negative regulation of replicative senescence namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] synonym: "down regulation of replicative senescence" EXACT [GOC:TermGenie] synonym: "down-regulation of replicative senescence" EXACT [GOC:TermGenie] synonym: "downregulation of replicative senescence" EXACT [GOC:TermGenie] synonym: "inhibition of replicative senescence" NARROW [GOC:TermGenie] is_a: GO:0090344 ! negative regulation of cell aging is_a: GO:1904726 ! regulation of replicative senescence intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090399 ! replicative senescence relationship: negatively_regulates GO:0090399 ! replicative senescence created_by: rph creation_date: 2015-10-14T13:11:31Z [Term] id: GO:1904728 name: positive regulation of replicative senescence namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] synonym: "activation of replicative senescence" NARROW [GOC:TermGenie] synonym: "up regulation of replicative senescence" EXACT [GOC:TermGenie] synonym: "up-regulation of replicative senescence" EXACT [GOC:TermGenie] synonym: "upregulation of replicative senescence" EXACT [GOC:TermGenie] is_a: GO:0090343 ! positive regulation of cell aging is_a: GO:1904726 ! regulation of replicative senescence intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090399 ! replicative senescence relationship: positively_regulates GO:0090399 ! replicative senescence created_by: rph creation_date: 2015-10-14T13:11:37Z [Term] id: GO:1904729 name: regulation of intestinal lipid absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:1904478 ! regulation of intestinal absorption intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098856 ! intestinal lipid absorption relationship: regulates GO:0098856 ! intestinal lipid absorption created_by: sl creation_date: 2015-10-14T15:24:56Z [Term] id: GO:1904730 name: negative regulation of intestinal lipid absorption namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] synonym: "down regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] synonym: "down-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] synonym: "downregulation of intestinal lipid absorption" EXACT [GOC:TermGenie] synonym: "inhibition of intestinal lipid absorption" NARROW [GOC:TermGenie] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:1904479 ! negative regulation of intestinal absorption is_a: GO:1904729 ! regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098856 ! intestinal lipid absorption relationship: negatively_regulates GO:0098856 ! intestinal lipid absorption created_by: sl creation_date: 2015-10-14T15:25:03Z [Term] id: GO:1904731 name: positive regulation of intestinal lipid absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] synonym: "activation of intestinal lipid absorption" NARROW [GOC:TermGenie] synonym: "up regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] synonym: "up-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] synonym: "upregulation of intestinal lipid absorption" EXACT [GOC:TermGenie] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:1904480 ! positive regulation of intestinal absorption is_a: GO:1904729 ! regulation of intestinal lipid absorption intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098856 ! intestinal lipid absorption relationship: positively_regulates GO:0098856 ! intestinal lipid absorption created_by: sl creation_date: 2015-10-14T15:25:10Z [Term] id: GO:1904732 name: regulation of electron transfer activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] synonym: "regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "regulation of azurin" NARROW [GOC:TermGenie] synonym: "regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "regulation of electron transporter activity" EXACT [GOC:TermGenie] synonym: "regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009055 ! electron transfer activity relationship: regulates GO:0009055 ! electron transfer activity created_by: lb creation_date: 2015-10-15T07:51:19Z [Term] id: GO:1904733 name: negative regulation of electron transfer activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] synonym: "down regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "down regulation of azurin" NARROW [GOC:TermGenie] synonym: "down regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "down regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "down regulation of electron carrier activity" EXACT [GOC:TermGenie] synonym: "down regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "down regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "down regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "down regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "down regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "down regulation of electron transporter activity" EXACT [GOC:TermGenie] synonym: "down regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "down regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "down regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "down regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "down regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "down regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "down-regulation of azurin" NARROW [GOC:TermGenie] synonym: "down-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "down-regulation of electron carrier activity" EXACT [GOC:TermGenie] synonym: "down-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "down-regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "down-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "down-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "down-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "down-regulation of electron transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "down-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "down-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "downregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "downregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of amicyanin" NARROW [GOC:TermGenie] synonym: "downregulation of azurin" NARROW [GOC:TermGenie] synonym: "downregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "downregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "downregulation of electron carrier activity" EXACT [GOC:TermGenie] synonym: "downregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "downregulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "downregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "downregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "downregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "downregulation of electron transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "downregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "downregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "downregulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "downregulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "downregulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "downregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "inhibition of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "inhibition of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of amicyanin" NARROW [GOC:TermGenie] synonym: "inhibition of azurin" NARROW [GOC:TermGenie] synonym: "inhibition of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of copper electron carrier" NARROW [GOC:TermGenie] synonym: "inhibition of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "inhibition of electron carrier activity" NARROW [GOC:TermGenie] synonym: "inhibition of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "inhibition of electron donor activity" NARROW [GOC:TermGenie] synonym: "inhibition of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "inhibition of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "inhibition of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "inhibition of electron transporter activity" NARROW [GOC:TermGenie] synonym: "inhibition of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "inhibition of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "inhibition of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "inhibition of polyferredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "inhibition of rubredoxin" NARROW [GOC:TermGenie] synonym: "inhibition of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "inhibition of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "negative regulation of azurin" NARROW [GOC:TermGenie] synonym: "negative regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "negative regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "negative regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "negative regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "negative regulation of electron transporter activity" EXACT [GOC:TermGenie] synonym: "negative regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "negative regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "negative regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:1904732 ! regulation of electron transfer activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009055 ! electron transfer activity relationship: negatively_regulates GO:0009055 ! electron transfer activity created_by: lb creation_date: 2015-10-15T07:51:26Z [Term] id: GO:1904734 name: positive regulation of electron transfer activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] synonym: "activation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "activation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "activation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "activation of amicyanin" NARROW [GOC:TermGenie] synonym: "activation of azurin" NARROW [GOC:TermGenie] synonym: "activation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "activation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "activation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "activation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "activation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "activation of electron carrier activity" NARROW [GOC:TermGenie] synonym: "activation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "activation of electron donor activity" NARROW [GOC:TermGenie] synonym: "activation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "activation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "activation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "activation of electron transporter activity" NARROW [GOC:TermGenie] synonym: "activation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "activation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "activation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "activation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "activation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "activation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "activation of rubredoxin" NARROW [GOC:TermGenie] synonym: "activation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "activation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "positive regulation of azurin" NARROW [GOC:TermGenie] synonym: "positive regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "positive regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "positive regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "positive regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "positive regulation of electron transporter activity" RELATED [GOC:TermGenie] synonym: "positive regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "positive regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "positive regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "up regulation of azurin" NARROW [GOC:TermGenie] synonym: "up regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "up regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "up regulation of electron carrier activity" RELATED [GOC:TermGenie] synonym: "up regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "up regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "up regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "up regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "up regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "up regulation of electron transporter activity" RELATED [GOC:TermGenie] synonym: "up regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "up regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "up regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "up regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "up regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "up regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of amicyanin" NARROW [GOC:TermGenie] synonym: "up-regulation of azurin" NARROW [GOC:TermGenie] synonym: "up-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "up-regulation of electron carrier activity" RELATED [GOC:TermGenie] synonym: "up-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "up-regulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "up-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "up-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "up-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "up-regulation of electron transporter activity" RELATED [GOC:TermGenie] synonym: "up-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "up-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "up-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "upregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] synonym: "upregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of amicyanin" NARROW [GOC:TermGenie] synonym: "upregulation of azurin" NARROW [GOC:TermGenie] synonym: "upregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of copper electron carrier" NARROW [GOC:TermGenie] synonym: "upregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of electron acceptor activity" NARROW [GOC:TermGenie] synonym: "upregulation of electron carrier activity" RELATED [GOC:TermGenie] synonym: "upregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] synonym: "upregulation of electron donor activity" NARROW [GOC:TermGenie] synonym: "upregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] synonym: "upregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] synonym: "upregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] synonym: "upregulation of electron transporter activity" RELATED [GOC:TermGenie] synonym: "upregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] synonym: "upregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] synonym: "upregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] synonym: "upregulation of polyferredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] synonym: "upregulation of rubredoxin" NARROW [GOC:TermGenie] synonym: "upregulation of small blue copper electron carrier" NARROW [GOC:TermGenie] synonym: "upregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1904732 ! regulation of electron transfer activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009055 ! electron transfer activity relationship: positively_regulates GO:0009055 ! electron transfer activity created_by: lb creation_date: 2015-10-15T07:51:32Z [Term] id: GO:1904735 name: regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] is_a: GO:0031998 ! regulation of fatty acid beta-oxidation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase relationship: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase created_by: lb creation_date: 2015-10-15T08:14:51Z [Term] id: GO:1904736 name: negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] synonym: "down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] synonym: "down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] synonym: "downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] synonym: "inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie] is_a: GO:0031999 ! negative regulation of fatty acid beta-oxidation is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase relationship: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase created_by: lb creation_date: 2015-10-15T08:14:57Z [Term] id: GO:1904737 name: positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] synonym: "activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie] synonym: "up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] synonym: "up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] synonym: "upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase relationship: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase created_by: lb creation_date: 2015-10-15T08:15:03Z [Term] id: GO:1904738 name: vascular associated smooth muscle cell migration namespace: biological_process def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "vascular smooth muscle cell migration" EXACT [] is_a: GO:0014909 ! smooth muscle cell migration created_by: rph creation_date: 2015-10-15T09:56:00Z [Term] id: GO:1904739 name: regulation of synapse organization by posttranscriptional regulation of gene expression namespace: biological_process def: "A posttranscriptional regulation of gene expression that results in regulation of synapse organization." [GO_REF:0000063, GOC:rb, GOC:TermGenie, PMID:20729808] synonym: "regulation of synapse development by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] synonym: "regulation of synapse morphogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] synonym: "regulation of synapse organisation by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] synonym: "regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0010608 ! posttranscriptional regulation of gene expression intersection_of: regulates GO:0050808 ! synapse organization created_by: tb creation_date: 2015-10-15T21:25:46Z [Term] id: GO:1904740 name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by general transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by RNA polymerase II transcription factor activity" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from Pol II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: tb creation_date: 2015-10-15T21:30:51Z [Term] id: GO:1904741 name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198] comment: This term was obsoleted because it represents a GO-CAM model. synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_obsolete: true created_by: tb creation_date: 2015-10-15T21:40:43Z [Term] id: GO:1904742 name: regulation of telomeric DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "regulation of telomeric repeat binding" EXACT [GOC:TermGenie] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042162 ! telomeric DNA binding relationship: regulates GO:0042162 ! telomeric DNA binding created_by: nc creation_date: 2015-10-19T12:18:48Z [Term] id: GO:1904743 name: negative regulation of telomeric DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "down regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "down-regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "downregulation of telomere binding" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "inhibition of telomere binding" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric repeat binding" NARROW [GOC:TermGenie] synonym: "negative regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "negative regulation of telomeric repeat binding" EXACT [GOC:TermGenie] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:1904742 ! regulation of telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042162 ! telomeric DNA binding relationship: negatively_regulates GO:0042162 ! telomeric DNA binding created_by: nc creation_date: 2015-10-19T12:18:55Z [Term] id: GO:1904744 name: positive regulation of telomeric DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "activation of telomere binding" NARROW [GOC:TermGenie] synonym: "activation of telomeric DNA binding" NARROW [GOC:TermGenie] synonym: "activation of telomeric repeat binding" NARROW [GOC:TermGenie] synonym: "positive regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "positive regulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "up regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "up-regulation of telomere binding" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric repeat binding" EXACT [GOC:TermGenie] synonym: "upregulation of telomere binding" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric repeat binding" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:1904742 ! regulation of telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042162 ! telomeric DNA binding relationship: positively_regulates GO:0042162 ! telomeric DNA binding created_by: nc creation_date: 2015-10-19T12:19:01Z [Term] id: GO:1904745 name: Atg1/ULK1 kinase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988] synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: dph creation_date: 2015-10-19T12:33:08Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902742 ! apoptotic process involved in development relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902742 ! apoptotic process involved in development relationship: positively_regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902742 ! apoptotic process involved in development relationship: regulates GO:1902742 ! apoptotic process involved in development created_by: es creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904749 name: regulation of protein localization to nucleolus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902570 ! protein localization to nucleolus relationship: regulates GO:1902570 ! protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:17Z [Term] id: GO:1904750 name: negative regulation of protein localization to nucleolus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902570 ! protein localization to nucleolus relationship: negatively_regulates GO:1902570 ! protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:24Z [Term] id: GO:1904751 name: positive regulation of protein localization to nucleolus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902570 ! protein localization to nucleolus relationship: positively_regulates GO:1902570 ! protein localization to nucleolus created_by: nc creation_date: 2015-10-19T15:16:30Z [Term] id: GO:1904752 name: regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014910 ! regulation of smooth muscle cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904738 ! vascular associated smooth muscle cell migration relationship: regulates GO:1904738 ! vascular associated smooth muscle cell migration created_by: rph creation_date: 2015-10-19T15:49:52Z [Term] id: GO:1904753 name: negative regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration relationship: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration created_by: rph creation_date: 2015-10-19T15:49:58Z [Term] id: GO:1904754 name: positive regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration relationship: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration created_by: rph creation_date: 2015-10-19T15:50:05Z [Term] id: GO:1904755 name: regulation of gut granule assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] synonym: "regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of gut granule formation" EXACT [GOC:TermGenie] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902900 ! gut granule assembly relationship: regulates GO:1902900 ! gut granule assembly created_by: ah creation_date: 2015-10-21T08:43:44Z [Term] id: GO:1904756 name: negative regulation of gut granule assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] synonym: "down regulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "down regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "down-regulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "downregulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "downregulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "inhibition of gut granule assembly" NARROW [GOC:TermGenie] synonym: "inhibition of gut granule biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of gut granule formation" NARROW [GOC:TermGenie] synonym: "negative regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of gut granule formation" EXACT [GOC:TermGenie] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1904755 ! regulation of gut granule assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902900 ! gut granule assembly relationship: negatively_regulates GO:1902900 ! gut granule assembly created_by: ah creation_date: 2015-10-21T08:43:51Z [Term] id: GO:1904757 name: positive regulation of gut granule assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] synonym: "activation of gut granule assembly" NARROW [GOC:TermGenie] synonym: "activation of gut granule biogenesis" NARROW [GOC:TermGenie] synonym: "activation of gut granule formation" NARROW [GOC:TermGenie] synonym: "positive regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "up regulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "up regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "up-regulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gut granule formation" EXACT [GOC:TermGenie] synonym: "upregulation of gut granule assembly" EXACT [GOC:TermGenie] synonym: "upregulation of gut granule biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of gut granule formation" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1904755 ! regulation of gut granule assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902900 ! gut granule assembly relationship: positively_regulates GO:1902900 ! gut granule assembly created_by: ah creation_date: 2015-10-21T08:43:57Z [Term] id: GO:1904758 name: protein localization to new growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a new growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:19431238] synonym: "protein localisation in new growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to new growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in new growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization to new cell tip after activation of bipolar cell growth" EXACT [] synonym: "protein localization to new growing cell end" EXACT [] synonym: "protein localization to post-NETO new cell end" EXACT [] synonym: "protein localization to post-NETO new cell tip" EXACT [] synonym: "protein localization to post-new end take-off new cell tip" EXACT [] is_a: GO:1902486 ! protein localization to growing cell tip created_by: mah creation_date: 2015-10-21T12:37:48Z [Term] id: GO:1904759 name: protein localization to equatorial microtubule organizing center namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:16611237] synonym: "protein localisation in equatorial microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localisation to equatorial microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localization in equatorial microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localization to eMTOC" EXACT [] is_a: GO:0072741 ! protein localization to cell division site is_a: GO:1905508 ! protein localization to microtubule organizing center created_by: mah creation_date: 2015-10-21T12:37:55Z [Term] id: GO:1904760 name: regulation of myofibroblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036446 ! myofibroblast differentiation relationship: regulates GO:0036446 ! myofibroblast differentiation created_by: rph creation_date: 2015-10-23T12:15:05Z [Term] id: GO:1904761 name: negative regulation of myofibroblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "down regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myofibroblast cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of myofibroblast differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1904760 ! regulation of myofibroblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036446 ! myofibroblast differentiation relationship: negatively_regulates GO:0036446 ! myofibroblast differentiation created_by: rph creation_date: 2015-10-23T12:15:11Z [Term] id: GO:1904762 name: positive regulation of myofibroblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] synonym: "activation of myofibroblast cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of myofibroblast differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1904760 ! regulation of myofibroblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036446 ! myofibroblast differentiation relationship: positively_regulates GO:0036446 ! myofibroblast differentiation created_by: rph creation_date: 2015-10-23T12:15:17Z [Term] id: GO:1904763 name: chaperone-mediated autophagy translocation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871] synonym: "chaperone-mediated autophagy receptor complex assembly" RELATED [GOC:TermGenie] synonym: "chaperone-mediated autophagy receptor complex formation" RELATED [GOC:TermGenie] synonym: "chaperone-mediated autophagy translocation complex formation" EXACT [GOC:TermGenie] synonym: "CMA receptor complex assembly" RELATED [GOC:TermGenie] synonym: "CMA receptor complex formation" RELATED [GOC:TermGenie] synonym: "CMA translocation complex assembly" EXACT [GOC:TermGenie] synonym: "CMA translocation complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly relationship: part_of GO:0061684 ! chaperone-mediated autophagy created_by: pad creation_date: 2015-10-26T16:34:29Z [Term] id: GO:1904764 name: chaperone-mediated autophagy translocation complex disassembly namespace: biological_process def: "The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871] synonym: "chaperone-mediated autophagy receptor complex disassembly" RELATED [GOC:TermGenie] synonym: "CMA receptor complex disassembly" RELATED [GOC:TermGenie] synonym: "CMA translocation complex disassembly" EXACT [GOC:TermGenie] is_a: GO:0032984 ! protein-containing complex disassembly created_by: pad creation_date: 2015-10-26T16:34:36Z [Term] id: GO:1904765 name: positive regulation of transcription from RNA polymerase II promoter in response to maltose namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus." [GO_REF:0000060, GOC:TermGenie, PMID:24224056] synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0071328 ! cellular response to maltose stimulus relationship: part_of GO:0071328 ! cellular response to maltose stimulus created_by: mah creation_date: 2015-10-26T16:42:15Z [Term] id: GO:1904766 name: negative regulation of macroautophagy by TORC1 signaling namespace: biological_process def: "A TORC1 signaling that results in negative regulation of macroautophagy." [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450] synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of macroautophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of non-specific autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of non-specific autophagy by TORC1 signaling" EXACT [GOC:TermGenie] synonym: "negative regulation of starvation-induced autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] synonym: "negative regulation of starvation-induced autophagy by TORC1 signaling" EXACT [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:0038202 ! TORC1 signaling intersection_of: GO:0038202 ! TORC1 signaling intersection_of: negatively_regulates GO:0016236 ! macroautophagy created_by: dph creation_date: 2015-10-26T18:34:47Z [Term] id: GO:1904767 name: octanoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with octanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] synonym: "caprylic acid binding" EXACT [CHEBI:28837] is_a: GO:0005504 ! fatty acid binding created_by: kmv creation_date: 2015-10-27T21:11:49Z [Term] id: GO:1904768 name: all-trans-retinol binding namespace: molecular_function def: "Interacting selectively and non-covalently with all-trans-retinol." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] is_a: GO:0019841 ! retinol binding created_by: kmv creation_date: 2015-10-27T21:14:47Z [Term] id: GO:1904769 name: isopentadecanoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with isopentadecanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] synonym: "13-methylmyristic acid binding" EXACT [CHEBI:39250] is_a: GO:0036041 ! long-chain fatty acid binding created_by: kmv creation_date: 2015-10-27T21:33:38Z [Term] id: GO:1904770 name: intramembranous bone morphogenesis namespace: biological_process def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686] synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie] synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0060349 ! bone morphogenesis created_by: dos creation_date: 2015-10-28T11:46:04Z [Term] id: GO:1904771 name: obsolete cellular response to doxorubicin namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19801496] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-10-28T20:48:30Z [Term] id: GO:1904772 name: response to tetrachloromethane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267] synonym: "response to carbon tetrachloride" EXACT [] synonym: "response to CCL4" EXACT [] is_a: GO:0010033 ! response to organic substance created_by: sl creation_date: 2015-10-28T20:59:15Z [Term] id: GO:1904773 name: obsolete cellular response to tetrachloromethane namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "cellular response to carbon tetrachloride" EXACT [] synonym: "cellular response to CCL4" EXACT [] is_obsolete: true created_by: sl creation_date: 2015-10-28T20:59:21Z [Term] id: GO:1904774 name: negative regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303] synonym: "down regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "down regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "down regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "down-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "down-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "downregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "downregulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "downregulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of coenzyme Q biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquinone anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquinone biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquinone biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquinone formation" NARROW [GOC:TermGenie] synonym: "inhibition of ubiquinone synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process relationship: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process created_by: sl creation_date: 2015-10-28T21:21:20Z [Term] id: GO:1904775 name: positive regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303] synonym: "activation of coenzyme Q biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ubiquinone anabolism" NARROW [GOC:TermGenie] synonym: "activation of ubiquinone biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of ubiquinone biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ubiquinone formation" NARROW [GOC:TermGenie] synonym: "activation of ubiquinone synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "up regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of ubiquinone anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie] is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006744 ! ubiquinone biosynthetic process relationship: positively_regulates GO:0006744 ! ubiquinone biosynthetic process created_by: sl creation_date: 2015-10-28T21:21:26Z [Term] id: GO:1904776 name: regulation of protein localization to cell cortex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072697 ! protein localization to cell cortex relationship: regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:01Z [Term] id: GO:1904777 name: negative regulation of protein localization to cell cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072697 ! protein localization to cell cortex relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:08Z [Term] id: GO:1904778 name: positive regulation of protein localization to cell cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072697 ! protein localization to cell cortex relationship: positively_regulates GO:0072697 ! protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:15Z [Term] id: GO:1904779 name: regulation of protein localization to centrosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). synonym: "regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071539 ! protein localization to centrosome relationship: regulates GO:0071539 ! protein localization to centrosome created_by: es creation_date: 2015-10-30T11:54:30Z [Term] id: GO:1904780 name: negative regulation of protein localization to centrosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). synonym: "down regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to centrosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to centrosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to centrosome" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to centrosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to centrosome" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1904779 ! regulation of protein localization to centrosome intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071539 ! protein localization to centrosome relationship: negatively_regulates GO:0071539 ! protein localization to centrosome created_by: es creation_date: 2015-10-30T11:54:47Z [Term] id: GO:1904781 name: positive regulation of protein localization to centrosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). synonym: "activation of protein localisation to centrosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization to centrosome" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to centrosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to centrosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to centrosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to centrosome" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1904779 ! regulation of protein localization to centrosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071539 ! protein localization to centrosome relationship: positively_regulates GO:0071539 ! protein localization to centrosome created_by: es creation_date: 2015-10-30T11:54:53Z [Term] id: GO:1904782 name: negative regulation of NMDA glutamate receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] synonym: "down regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "down regulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "down-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "downregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "inhibition of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie] synonym: "inhibition of NMDA glutamate receptor activity" NARROW [GOC:TermGenie] synonym: "inhibition of NMDA receptor" NARROW [GOC:TermGenie] synonym: "negative regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of NMDA receptor" EXACT [GOC:TermGenie] is_a: GO:1900450 ! negative regulation of glutamate receptor signaling pathway is_a: GO:2000272 ! negative regulation of signaling receptor activity is_a: GO:2000310 ! regulation of NMDA receptor activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004972 ! NMDA glutamate receptor activity relationship: negatively_regulates GO:0004972 ! NMDA glutamate receptor activity created_by: mr creation_date: 2015-10-30T19:39:31Z [Term] id: GO:1904783 name: positive regulation of NMDA glutamate receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] synonym: "activation of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie] synonym: "activation of NMDA glutamate receptor activity" NARROW [GOC:TermGenie] synonym: "activation of NMDA receptor" NARROW [GOC:TermGenie] synonym: "positive regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "up regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "up regulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "up-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of NMDA receptor" EXACT [GOC:TermGenie] synonym: "upregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of NMDA receptor" EXACT [GOC:TermGenie] is_a: GO:1900451 ! positive regulation of glutamate receptor signaling pathway is_a: GO:2000273 ! positive regulation of signaling receptor activity is_a: GO:2000310 ! regulation of NMDA receptor activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004972 ! NMDA glutamate receptor activity relationship: positively_regulates GO:0004972 ! NMDA glutamate receptor activity created_by: mr creation_date: 2015-10-30T19:39:37Z [Term] id: GO:1904784 name: NLRP1 inflammasome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex." [GO_REF:0000079, GOC:TermGenie, PMID:19124602] comment: The aggregation, arrangement and bonding together of a set of components to form the NLRP1 inflammasome complex, occurring at the level of an individual cell. synonym: "NALP1 inflammasome complex assembly" EXACT [GOC:TermGenie] synonym: "NALP1 inflammasome complex formation" EXACT [GOC:TermGenie] synonym: "NLRP1 inflammasome complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: ae creation_date: 2015-11-02T09:39:44Z [Term] id: GO:1904785 name: regulation of asymmetric protein localization involved in cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) synonym: "regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:1905933 ! regulation of cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination relationship: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination created_by: es creation_date: 2015-11-03T12:11:06Z [Term] id: GO:1904786 name: negative regulation of asymmetric protein localization involved in cell fate determination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) synonym: "down regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "down regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "down regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "down regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "down regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "down-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "down-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "down-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "down-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "downregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "downregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "downregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "downregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "inhibition of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie] synonym: "inhibition of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie] synonym: "inhibition of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie] synonym: "inhibition of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie] synonym: "inhibition of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "negative regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "negative regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "negative regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination is_a: GO:1905934 ! negative regulation of cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination relationship: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination created_by: es creation_date: 2015-11-03T12:11:13Z [Term] id: GO:1904787 name: positive regulation of asymmetric protein localization involved in cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) synonym: "activation of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie] synonym: "activation of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie] synonym: "activation of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie] synonym: "activation of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie] synonym: "activation of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie] synonym: "positive regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "positive regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "positive regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "positive regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "up regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "up regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "up regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "up regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "up-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "up-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "up-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "up-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "upregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] synonym: "upregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] synonym: "upregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] synonym: "upregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination is_a: GO:1905935 ! positive regulation of cell fate determination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination relationship: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination created_by: es creation_date: 2015-11-03T12:11:19Z [Term] id: GO:1904788 name: positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:22144909] synonym: "positive regulation of induction of conjugation with cellular fusion by global transcription regulation from Pol II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] is_a: GO:1900237 ! positive regulation of induction of conjugation with cellular fusion is_a: GO:1900406 ! regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter intersection_of: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion created_by: tb creation_date: 2015-11-04T21:17:08Z [Term] id: GO:1904789 name: regulation of mitotic actomyosin contractile ring maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance." [GO_REF:0000058, GOC:TermGenie, PMID:24115772] synonym: "regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1903436 ! regulation of mitotic cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902406 ! mitotic actomyosin contractile ring maintenance relationship: regulates GO:1902406 ! mitotic actomyosin contractile ring maintenance created_by: mah creation_date: 2015-11-06T15:42:49Z [Term] id: GO:1904790 name: regulation of shelterin complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] synonym: "regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "regulation of telosome assembly" EXACT [] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071573 ! shelterin complex assembly relationship: regulates GO:0071573 ! shelterin complex assembly created_by: nc creation_date: 2015-11-06T16:13:03Z [Term] id: GO:1904791 name: negative regulation of shelterin complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] synonym: "down regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of telosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of telosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of telosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of Pot1 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of shelterin complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of telosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of telosome assembly" EXACT [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1904790 ! regulation of shelterin complex assembly is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071573 ! shelterin complex assembly relationship: negatively_regulates GO:0071573 ! shelterin complex assembly created_by: nc creation_date: 2015-11-06T16:13:11Z [Term] id: GO:1904792 name: positive regulation of shelterin complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] synonym: "activation of Pot1 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of shelterin complex formation" NARROW [GOC:TermGenie] synonym: "activation of telosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of telosome assembly" EXACT [] synonym: "up regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of telosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of telosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Pot1 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of shelterin complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of telosome assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1904790 ! regulation of shelterin complex assembly is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071573 ! shelterin complex assembly relationship: positively_regulates GO:0071573 ! shelterin complex assembly created_by: nc creation_date: 2015-11-06T16:13:18Z [Term] id: GO:1904793 name: regulation of euchromatin binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] is_a: GO:0035561 ! regulation of chromatin binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990188 ! euchromatin binding relationship: regulates GO:1990188 ! euchromatin binding created_by: nc creation_date: 2015-11-09T11:43:04Z [Term] id: GO:1904794 name: negative regulation of euchromatin binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "down regulation of euchromatin binding" EXACT [GOC:TermGenie] synonym: "down-regulation of euchromatin binding" EXACT [GOC:TermGenie] synonym: "downregulation of euchromatin binding" EXACT [GOC:TermGenie] synonym: "inhibition of euchromatin binding" NARROW [GOC:TermGenie] is_a: GO:0035562 ! negative regulation of chromatin binding is_a: GO:1904793 ! regulation of euchromatin binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990188 ! euchromatin binding relationship: negatively_regulates GO:1990188 ! euchromatin binding created_by: nc creation_date: 2015-11-09T11:43:12Z [Term] id: GO:1904795 name: positive regulation of euchromatin binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "activation of euchromatin binding" NARROW [GOC:TermGenie] synonym: "up regulation of euchromatin binding" EXACT [GOC:TermGenie] synonym: "up-regulation of euchromatin binding" EXACT [GOC:TermGenie] synonym: "upregulation of euchromatin binding" EXACT [GOC:TermGenie] is_a: GO:0035563 ! positive regulation of chromatin binding is_a: GO:1904793 ! regulation of euchromatin binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990188 ! euchromatin binding relationship: positively_regulates GO:1990188 ! euchromatin binding created_by: nc creation_date: 2015-11-09T11:43:19Z [Term] id: GO:1904796 name: regulation of core promoter binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001047 ! core promoter binding relationship: regulates GO:0001047 ! core promoter binding created_by: nc creation_date: 2015-11-09T12:32:23Z [Term] id: GO:1904797 name: negative regulation of core promoter binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "down regulation of core promoter binding" EXACT [GOC:TermGenie] synonym: "down-regulation of core promoter binding" EXACT [GOC:TermGenie] synonym: "downregulation of core promoter binding" EXACT [GOC:TermGenie] synonym: "inhibition of core promoter binding" NARROW [GOC:TermGenie] is_a: GO:1904796 ! regulation of core promoter binding is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001047 ! core promoter binding relationship: negatively_regulates GO:0001047 ! core promoter binding created_by: nc creation_date: 2015-11-09T12:32:31Z [Term] id: GO:1904798 name: positive regulation of core promoter binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] synonym: "activation of core promoter binding" NARROW [GOC:TermGenie] synonym: "up regulation of core promoter binding" EXACT [GOC:TermGenie] synonym: "up-regulation of core promoter binding" EXACT [GOC:TermGenie] synonym: "upregulation of core promoter binding" EXACT [GOC:TermGenie] is_a: GO:1904796 ! regulation of core promoter binding is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001047 ! core promoter binding relationship: positively_regulates GO:0001047 ! core promoter binding created_by: nc creation_date: 2015-11-09T12:32:38Z [Term] id: GO:1904799 name: regulation of neuron remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) synonym: "regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "regulation of neuronal remodeling" EXACT [GOC:TermGenie] is_a: GO:0014041 ! regulation of neuron maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016322 ! neuron remodeling relationship: regulates GO:0016322 ! neuron remodeling created_by: es creation_date: 2015-11-09T13:46:52Z [Term] id: GO:1904800 name: negative regulation of neuron remodeling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) synonym: "down regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "down regulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "down regulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "down-regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "down-regulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "down-regulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "downregulation of axon pruning" NARROW [GOC:TermGenie] synonym: "downregulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "downregulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "inhibition of axon pruning" NARROW [GOC:TermGenie] synonym: "inhibition of neuron remodeling" NARROW [GOC:TermGenie] synonym: "inhibition of neuronal remodeling" NARROW [GOC:TermGenie] synonym: "negative regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "negative regulation of neuronal remodeling" EXACT [GOC:TermGenie] is_a: GO:0014043 ! negative regulation of neuron maturation is_a: GO:1904799 ! regulation of neuron remodeling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016322 ! neuron remodeling relationship: negatively_regulates GO:0016322 ! neuron remodeling created_by: es creation_date: 2015-11-09T13:47:00Z [Term] id: GO:1904801 name: positive regulation of neuron remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) synonym: "activation of axon pruning" NARROW [GOC:TermGenie] synonym: "activation of neuron remodeling" NARROW [GOC:TermGenie] synonym: "activation of neuronal remodeling" NARROW [GOC:TermGenie] synonym: "positive regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "positive regulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "up regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "up regulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "up regulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "up-regulation of axon pruning" NARROW [GOC:TermGenie] synonym: "up-regulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "up-regulation of neuronal remodeling" EXACT [GOC:TermGenie] synonym: "upregulation of axon pruning" NARROW [GOC:TermGenie] synonym: "upregulation of neuron remodeling" EXACT [GOC:TermGenie] synonym: "upregulation of neuronal remodeling" EXACT [GOC:TermGenie] is_a: GO:0014042 ! positive regulation of neuron maturation is_a: GO:1904799 ! regulation of neuron remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016322 ! neuron remodeling relationship: positively_regulates GO:0016322 ! neuron remodeling created_by: es creation_date: 2015-11-09T13:47:07Z [Term] id: GO:1904802 name: RITS complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a RITS complex." [GO_REF:0000079, GOC:TermGenie, PMID:26443059] synonym: "RITS complex formation" EXACT [GOC:TermGenie] is_a: GO:0022618 ! ribonucleoprotein complex assembly created_by: mah creation_date: 2015-11-09T16:17:54Z [Term] id: GO:1904803 name: regulation of translation involved in cellular response to UV namespace: biological_process def: "Any regulation of translation that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:17369398] synonym: "regulation of protein anabolism involved in cellular response to UV" EXACT [GOC:TermGenie] synonym: "regulation of protein biosynthesis involved in cellular response to UV" EXACT [GOC:TermGenie] synonym: "regulation of protein formation involved in cellular response to UV" EXACT [GOC:TermGenie] synonym: "regulation of protein synthesis involved in cellular response to UV" EXACT [GOC:TermGenie] synonym: "regulation of translation involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie] synonym: "regulation of translation involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie] synonym: "regulation of translation involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie] synonym: "regulation of translation involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0006417 ! regulation of translation intersection_of: part_of GO:0034644 ! cellular response to UV relationship: part_of GO:0034644 ! cellular response to UV created_by: mah creation_date: 2015-11-10T12:12:41Z [Term] id: GO:1904804 name: response to latrunculin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703] is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol created_by: mah creation_date: 2015-11-10T14:00:38Z [Term] id: GO:1904805 name: cellular response to latrunculin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1904804 ! response to latrunculin A created_by: mah creation_date: 2015-11-10T14:00:46Z [Term] id: GO:1904806 name: regulation of protein oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] synonym: "regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018158 ! protein oxidation relationship: regulates GO:0018158 ! protein oxidation created_by: mec creation_date: 2015-11-10T14:06:00Z [Term] id: GO:1904807 name: negative regulation of protein oxidation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] synonym: "down regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "down regulation of protein oxidation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein oxidation" EXACT [GOC:TermGenie] synonym: "downregulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "downregulation of protein oxidation" EXACT [GOC:TermGenie] synonym: "inhibition of protein amino acid oxidation" NARROW [GOC:TermGenie] synonym: "inhibition of protein oxidation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1904806 ! regulation of protein oxidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018158 ! protein oxidation relationship: negatively_regulates GO:0018158 ! protein oxidation created_by: mec creation_date: 2015-11-10T14:06:08Z [Term] id: GO:1904808 name: positive regulation of protein oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] synonym: "activation of protein amino acid oxidation" NARROW [GOC:TermGenie] synonym: "activation of protein oxidation" NARROW [GOC:TermGenie] synonym: "positive regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "up regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "up regulation of protein oxidation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein oxidation" EXACT [GOC:TermGenie] synonym: "upregulation of protein amino acid oxidation" EXACT [GOC:TermGenie] synonym: "upregulation of protein oxidation" EXACT [GOC:TermGenie] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1904806 ! regulation of protein oxidation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018158 ! protein oxidation relationship: positively_regulates GO:0018158 ! protein oxidation created_by: mec creation_date: 2015-11-10T14:06:15Z [Term] id: GO:1904809 name: regulation of dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901950 ! dense core granule transport relationship: regulates GO:1901950 ! dense core granule transport created_by: es creation_date: 2015-11-11T10:40:10Z [Term] id: GO:1904810 name: negative regulation of dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie] synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:1903650 ! negative regulation of cytoplasmic transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901950 ! dense core granule transport relationship: negatively_regulates GO:1901950 ! dense core granule transport created_by: es creation_date: 2015-11-11T10:40:18Z [Term] id: GO:1904811 name: positive regulation of dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie] synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:1903651 ! positive regulation of cytoplasmic transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901950 ! dense core granule transport relationship: positively_regulates GO:1901950 ! dense core granule transport created_by: es creation_date: 2015-11-11T10:40:25Z [Term] id: GO:1904812 name: rRNA acetylation involved in maturation of SSU-rRNA namespace: biological_process def: "Any rRNA acetylation that is involved in maturation of SSU-rRNA." [GO_REF:0000060, GOC:TermGenie, PMID:25402480] synonym: "rRNA acetylation involved in processing of 20S pre-rRNA" NARROW [GOC:TermGenie] synonym: "rRNA acetylation involved in SSU-rRNA maturation" EXACT [GOC:TermGenie] is_a: GO:1990882 ! rRNA acetylation intersection_of: GO:1990882 ! rRNA acetylation intersection_of: part_of GO:0030490 ! maturation of SSU-rRNA relationship: part_of GO:0030490 ! maturation of SSU-rRNA created_by: al creation_date: 2015-11-11T15:38:41Z [Term] id: GO:1904813 name: ficolin-1-rich granule lumen namespace: cellular_component def: "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] synonym: "ficolin-1-rich granule membrane-enclosed lumen" EXACT [] synonym: "membrane-enclosed lumen of ficolin granule" RELATED [GOC:TermGenie] synonym: "membrane-enclosed lumen of ficolin-1 rich granule" EXACT [GOC:TermGenie] synonym: "membrane-enclosed lumen of ficolin-1-rich granule" EXACT [GOC:TermGenie] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0101002 ! ficolin-1-rich granule relationship: part_of GO:0101002 ! ficolin-1-rich granule created_by: mec creation_date: 2015-11-13T11:58:20Z [Term] id: GO:1904814 name: regulation of protein localization to chromosome, telomeric region namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] synonym: "regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "regulation of protein localization to telomere" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070198 ! protein localization to chromosome, telomeric region relationship: regulates GO:0070198 ! protein localization to chromosome, telomeric region created_by: nc creation_date: 2015-11-16T12:18:43Z [Term] id: GO:1904815 name: negative regulation of protein localization to chromosome, telomeric region namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] synonym: "down regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to telomere" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization to telomere" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region relationship: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region created_by: nc creation_date: 2015-11-16T12:18:51Z [Term] id: GO:1904816 name: positive regulation of protein localization to chromosome, telomeric region namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] synonym: "activation of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "activation of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "activation of protein localization to telomere" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to telomere" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region relationship: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region created_by: nc creation_date: 2015-11-16T12:18:58Z [Term] id: GO:1904817 name: serous membrane development namespace: biological_process def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "serosa development" RELATED [GOC:TermGenie] synonym: "tunica serosa development" EXACT [GOC:TermGenie] synonym: "wall of serous sac development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2015-11-17T19:00:01Z [Term] id: GO:1904818 name: visceral peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:1904820 ! peritoneum development created_by: dph creation_date: 2015-11-17T19:00:17Z [Term] id: GO:1904819 name: parietal peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:1904820 ! peritoneum development created_by: dph creation_date: 2015-11-17T19:00:24Z [Term] id: GO:1904820 name: peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritonaeum development" RELATED [GOC:TermGenie] is_a: GO:1904817 ! serous membrane development created_by: dph creation_date: 2015-11-18T17:23:51Z [Term] id: GO:1904821 name: chloroplast disassembly namespace: biological_process def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759] comment: The disaggregation of a chloroplast into its constituent components. synonym: "chloroplast degradation" RELATED [PMID:26494759] is_a: GO:0009658 ! chloroplast organization is_a: GO:1903008 ! organelle disassembly created_by: lr creation_date: 2015-11-19T00:41:18Z [Term] id: GO:1904823 name: purine nucleobase transmembrane transport namespace: biological_process def: "The process in which a purine nucleobase is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0006863 ! purine nucleobase transport is_a: GO:0072530 ! purine-containing compound transmembrane transport created_by: vw creation_date: 2015-11-19T09:07:56Z [Term] id: GO:1904824 name: anaphase-promoting complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex." [GO_REF:0000079, GOC:TermGenie, PMID:16950791] synonym: "anaphase promoting complex assembly" EXACT [GOC:TermGenie] synonym: "anaphase promoting complex formation" EXACT [GOC:TermGenie] synonym: "anaphase-promoting complex formation" EXACT [GOC:TermGenie] synonym: "APC assembly" BROAD [] synonym: "cyclosome assembly" EXACT [GOC:TermGenie] synonym: "cyclosome formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2015-11-23T12:28:59Z [Term] id: GO:1904825 name: protein localization to microtubule plus-end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245] synonym: "protein localisation to microtubule plus-end" EXACT [GOC:TermGenie] is_a: GO:1905725 ! protein localization to microtubule end created_by: mah creation_date: 2015-11-23T12:34:09Z [Term] id: GO:1904826 name: regulation of hydrogen sulfide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070814 ! hydrogen sulfide biosynthetic process relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process created_by: rph creation_date: 2015-11-24T10:15:26Z [Term] id: GO:1904827 name: negative regulation of hydrogen sulfide biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "down regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "inhibition of hydrogen sulfide anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulfide formation" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulfide synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie] synonym: "negative regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process relationship: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process created_by: rph creation_date: 2015-11-24T10:15:34Z [Term] id: GO:1904828 name: positive regulation of hydrogen sulfide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "activation of hydrogen sulfide anabolism" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulfide formation" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulfide synthesis" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process relationship: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process created_by: rph creation_date: 2015-11-24T10:15:41Z [Term] id: GO:1904829 name: regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:40Z [Term] id: GO:1904830 name: negative regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:47Z [Term] id: GO:1904831 name: positive regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation created_by: rph creation_date: 2015-11-24T10:20:54Z [Term] id: GO:1904832 name: negative regulation of removal of superoxide radicals namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756] synonym: "down regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "down regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "down regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "down regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "down-regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "down-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "down-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] synonym: "downregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "downregulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "downregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "downregulation of removal of superoxide radicals" EXACT [GOC:TermGenie] synonym: "inhibition of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie] synonym: "inhibition of removal of O2-" NARROW [GOC:TermGenie] synonym: "inhibition of removal of oxygen free radicals" NARROW [GOC:TermGenie] synonym: "inhibition of removal of superoxide radicals" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "negative regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "negative regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress is_a: GO:1901032 ! negative regulation of response to reactive oxygen species is_a: GO:2000121 ! regulation of removal of superoxide radicals is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019430 ! removal of superoxide radicals relationship: negatively_regulates GO:0019430 ! removal of superoxide radicals created_by: rph creation_date: 2015-11-24T15:30:18Z [Term] id: GO:1904833 name: positive regulation of removal of superoxide radicals namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756] synonym: "activation of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie] synonym: "activation of removal of O2-" NARROW [GOC:TermGenie] synonym: "activation of removal of oxygen free radicals" NARROW [GOC:TermGenie] synonym: "activation of removal of superoxide radicals" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "positive regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "positive regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "up regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "up regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "up regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "up regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "up-regulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "up-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "up-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] synonym: "upregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] synonym: "upregulation of removal of O2-" EXACT [GOC:TermGenie] synonym: "upregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] synonym: "upregulation of removal of superoxide radicals" EXACT [GOC:TermGenie] is_a: GO:1900409 ! positive regulation of cellular response to oxidative stress is_a: GO:1901033 ! positive regulation of response to reactive oxygen species is_a: GO:2000121 ! regulation of removal of superoxide radicals is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019430 ! removal of superoxide radicals relationship: positively_regulates GO:0019430 ! removal of superoxide radicals created_by: rph creation_date: 2015-11-24T15:30:26Z [Term] id: GO:1904834 name: nuclear CENP-A containing chromatin namespace: cellular_component def: "Any CENP-A containing chromatin that is part of nuclear chromatin." [GO_REF:0000064, GOC:TermGenie, PMID:24710126] synonym: "nuclear centromeric core domain chromatin" RELATED [] synonym: "nuclear centromeric core region chromatin" EXACT [] synonym: "nuclear chromatin containing CENP-A" EXACT [] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0061638 ! CENP-A containing chromatin created_by: mah creation_date: 2015-11-30T12:32:34Z [Term] id: GO:1904835 name: dorsal root ganglion morphogenesis namespace: biological_process def: "The developmental process by which a dorsal root ganglion is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] synonym: "dorsal root ganglia morphogenesis" RELATED [GOC:TermGenie] synonym: "DRG morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion of dorsal root morphogenesis" EXACT [GOC:TermGenie] synonym: "ganglion sensorium nervi spinalis morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion spinale morphogenesis" RELATED [GOC:TermGenie] synonym: "ganglion spinalis morphogenesis" EXACT [GOC:TermGenie] synonym: "posterior root ganglion morphogenesis" RELATED [GOC:TermGenie] synonym: "spinal ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "spinal ganglion part of peripheral nervous system morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0061552 ! ganglion morphogenesis relationship: part_of GO:1990791 ! dorsal root ganglion development created_by: bf creation_date: 2015-12-01T16:41:17Z [Term] id: GO:1904836 name: facioacoustic ganglion morphogenesis namespace: biological_process def: "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized." [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "acoustico-facial VII-VIII ganglion complex morphogenesis" EXACT [UBERON:0012175] synonym: "acousticofacial ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion complex morphogenesis" RELATED [GOC:TermGenie] synonym: "facio-acoustic ganglion complex VII-VIII morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic ganglion morphogenesis" EXACT [GOC:TermGenie] synonym: "facio-acoustic VII-VIII ganglion complex morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0061559 ! cranial ganglion morphogenesis relationship: part_of GO:1903375 ! facioacoustic ganglion development created_by: bf creation_date: 2015-12-01T17:02:06Z [Term] id: GO:1904837 name: beta-catenin-TCF complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] synonym: "beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: bf creation_date: 2015-12-03T17:20:26Z [Term] id: GO:1904838 name: regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000035 ! regulation of stem cell division is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048133 ! male germ-line stem cell asymmetric division relationship: regulates GO:0048133 ! male germ-line stem cell asymmetric division created_by: sl creation_date: 2015-12-05T00:28:31Z [Term] id: GO:1904839 name: negative regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "down regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "down regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "down-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "downregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] synonym: "inhibition of male germ-line stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045769 ! negative regulation of asymmetric cell division is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division relationship: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division created_by: sl creation_date: 2015-12-05T00:28:39Z [Term] id: GO:1904840 name: positive regulation of male germ-line stem cell asymmetric division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] synonym: "activation of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] synonym: "activation of male germ-line stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "up regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "up-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] synonym: "upregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045770 ! positive regulation of asymmetric cell division is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division relationship: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division created_by: sl creation_date: 2015-12-05T00:28:46Z [Term] id: GO:1904841 name: TORC2 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a TORC2 complex." [GO_REF:000102, GOC:TermGenie, Pubmed:20660630] comment: Interacting selectively and non-covalently with a TORC2 complex, a protein complex that mediates the phosphorylation of protein kinase B synonym: "mTORC2 binding" NARROW [GOC:TermGenie] synonym: "rapamycin and nutrient-insensitive TOR complex binding" EXACT [GOC:TermGenie] synonym: "TOR complex 2 binding" EXACT [GOC:TermGenie] synonym: "TORC 2 complex binding" EXACT [GOC:TermGenie] synonym: "TORC2 binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: pf creation_date: 2015-12-07T16:59:44Z [Term] id: GO:1904842 name: response to nitroglycerin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975] synonym: "response to nitroglycerine" EXACT [] synonym: "response to nitroglycerol" EXACT [] synonym: "response to trinitroglycerin" EXACT [] synonym: "response to trinitroglycerol" EXACT [] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-12-07T18:30:47Z [Term] id: GO:1904843 name: cellular response to nitroglycerin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975] synonym: "cellular response to nitroglycerine" EXACT [] synonym: "cellular response to nitroglycerol" EXACT [] synonym: "cellular response to trinitroglycerin" EXACT [] synonym: "cellular response to trinitroglycerol" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904842 ! response to nitroglycerin created_by: sl creation_date: 2015-12-07T18:30:55Z [Term] id: GO:1904844 name: response to L-glutamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] is_a: GO:0007584 ! response to nutrient is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2015-12-07T19:39:17Z [Term] id: GO:1904845 name: cellular response to L-glutamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1904844 ! response to L-glutamine created_by: sl creation_date: 2015-12-07T19:39:24Z [Term] id: GO:1904846 name: negative regulation of establishment of bipolar cell polarity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity." [GO_REF:0000058, GOC:TermGenie, PMID:26525038] synonym: "down regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of bipolar cell polarity" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity relationship: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity created_by: al creation_date: 2015-12-08T15:06:30Z [Term] id: GO:1904847 name: regulation of cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor relationship: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor created_by: rph creation_date: 2015-12-10T12:04:01Z [Term] id: GO:1904848 name: negative regulation of cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] synonym: "down regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] synonym: "down-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] synonym: "downregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] synonym: "inhibition of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor relationship: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor created_by: rph creation_date: 2015-12-10T12:04:08Z [Term] id: GO:1904849 name: positive regulation of cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] synonym: "activation of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie] synonym: "up regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] synonym: "up-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] synonym: "upregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor relationship: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor created_by: rph creation_date: 2015-12-10T12:04:16Z [Term] id: GO:1904850 name: negative regulation of establishment of protein localization to telomere namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "down regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation to telomere" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization to telomere" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] is_a: GO:0070203 ! regulation of establishment of protein localization to telomere is_a: GO:1904815 ! negative regulation of protein localization to chromosome, telomeric region is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070200 ! establishment of protein localization to telomere relationship: negatively_regulates GO:0070200 ! establishment of protein localization to telomere created_by: nc creation_date: 2015-12-10T15:37:51Z [Term] id: GO:1904851 name: positive regulation of establishment of protein localization to telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "activation of establishment of protein localisation to telomere" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization to telomere" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] is_a: GO:0070203 ! regulation of establishment of protein localization to telomere is_a: GO:1904816 ! positive regulation of protein localization to chromosome, telomeric region is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070200 ! establishment of protein localization to telomere relationship: positively_regulates GO:0070200 ! establishment of protein localization to telomere created_by: nc creation_date: 2015-12-10T15:37:58Z [Term] id: GO:1904852 name: trimethylamine-N-oxide reductase (cytochrome c) complex namespace: cellular_component def: "A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172] comment: An example of this is TorA in E. coli (UniProt ID P33225) in PMID:11056172 (inferred from direct assay). is_a: GO:1990204 ! oxidoreductase complex created_by: bhm creation_date: 2015-12-14T09:11:10Z [Term] id: GO:1904853 name: protein localization to ascospore wall namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an ascospore wall." [GO_REF:0000087, GOC:TermGenie, PMID:24623719] synonym: "protein localisation in ascospore wall" EXACT [GOC:TermGenie] synonym: "protein localisation to ascospore wall" EXACT [GOC:TermGenie] synonym: "protein localization in ascospore wall" EXACT [GOC:TermGenie] is_a: GO:0099614 ! protein localization to spore cell wall created_by: mah creation_date: 2015-12-14T12:52:50Z [Term] id: GO:1904854 name: proteasome core complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome core complex." [GO_REF:000102, GOC:TermGenie, PMID:16096059] synonym: "20S core complex binding" NARROW [GOC:TermGenie] synonym: "20S proteasome binding" NARROW [GOC:TermGenie] synonym: "macropain binding" EXACT [GOC:TermGenie] synonym: "PA28gamma-20S proteasome binding" NARROW [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: mah creation_date: 2015-12-15T11:54:19Z [Term] id: GO:1904855 name: proteasome regulatory particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome regulatory particle." [GO_REF:000102, GOC:TermGenie, PMID:16096059] synonym: "19S regulatory particle binding" NARROW [GOC:TermGenie] synonym: "modulator complex binding" RELATED [GOC:TermGenie] synonym: "PA700 proteasome activator binding" NARROW [GOC:TermGenie] synonym: "PA700-dependent proteasome activator binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: mah creation_date: 2015-12-15T11:54:27Z [Term] id: GO:1904856 name: cytolytic granule lumen namespace: cellular_component def: "Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule." [GO_REF:0000064, GOC:TermGenie, PMID:17272266, PMID:21247065] synonym: "cytolytic granule cytoplasmic membrane-bounded vesicle lumen" EXACT [] synonym: "cytoplasmic membrane-bounded vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie] synonym: "cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie] is_a: GO:0005775 ! vacuolar lumen is_a: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: GO:0060205 ! cytoplasmic vesicle lumen intersection_of: part_of GO:0044194 ! cytolytic granule relationship: part_of GO:0044194 ! cytolytic granule created_by: mec creation_date: 2015-12-15T12:51:17Z [Term] id: GO:1904857 name: regulation of endothelial cell chemotaxis to vascular endothelial growth factor namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor relationship: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor created_by: rph creation_date: 2015-12-16T11:47:44Z [Term] id: GO:1904858 name: negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] synonym: "down regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor relationship: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor created_by: rph creation_date: 2015-12-16T11:47:52Z [Term] id: GO:1904859 name: positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] synonym: "activation of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor relationship: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor created_by: rph creation_date: 2015-12-16T11:48:00Z [Term] id: GO:1904860 name: DNA biosynthetic process involved in mitotic DNA replication namespace: biological_process def: "Any DNA biosynthetic process that is involved in mitotic DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:16849602] synonym: "DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA anabolism involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA anabolism involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "DNA anabolism involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA biosynthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA biosynthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA biosynthetic process involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA formation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA formation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA formation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "DNA formation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0090592 ! DNA synthesis involved in DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0071897 ! DNA biosynthetic process intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:1902969 ! mitotic DNA replication created_by: mah creation_date: 2015-12-16T12:02:37Z [Term] id: GO:1904861 name: excitatory synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] synonym: "excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0007416 ! synapse assembly created_by: bf creation_date: 2015-12-17T10:31:26Z [Term] id: GO:1904862 name: inhibitory synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "inhibitory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0007416 ! synapse assembly created_by: bf creation_date: 2015-12-17T10:31:34Z [Term] id: GO:1904863 name: regulation of beta-catenin-TCF complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904837 ! beta-catenin-TCF complex assembly relationship: regulates GO:1904837 ! beta-catenin-TCF complex assembly created_by: bf creation_date: 2015-12-17T13:50:39Z [Term] id: GO:1904864 name: negative regulation of beta-catenin-TCF complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] synonym: "down regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "down regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "down regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "down regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "down-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "down-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "downregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "downregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "downregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "downregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "inhibition of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "inhibition of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "negative regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "negative regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly relationship: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly created_by: bf creation_date: 2015-12-17T13:50:46Z [Term] id: GO:1904865 name: positive regulation of beta-catenin-TCF complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie] synonym: "activation of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie] synonym: "activation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "activation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "activation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "activation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "positive regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "positive regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "up regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "up regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "up regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "up regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "up-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "up-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] synonym: "upregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] synonym: "upregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] synonym: "upregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] synonym: "upregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly relationship: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly created_by: bf creation_date: 2015-12-17T13:50:53Z [Term] id: GO:1904866 name: ventral tegmental area development namespace: biological_process def: "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362] synonym: "a10a development" EXACT [GOC:TermGenie] synonym: "area tegmentalis ventralis (Tsai) development" RELATED [GOC:TermGenie] synonym: "area tegmentalis ventralis development" RELATED [GOC:TermGenie] synonym: "tegmentum ventrale development" RELATED [GOC:TermGenie] synonym: "ventral brain stem development" RELATED [GOC:TermGenie] synonym: "ventral tegmental area (Tsai) development" RELATED [GOC:TermGenie] synonym: "ventral tegmental area of tsai development" EXACT [GOC:TermGenie] synonym: "ventral tegmental nucleus (Rioch) development" RELATED [GOC:TermGenie] synonym: "ventral tegmental nucleus (tsai) development" EXACT [GOC:TermGenie] synonym: "ventral tegmental nucleus of tsai development" EXACT [GOC:TermGenie] synonym: "ventral tegmentum development" EXACT [Wikipedia:Ventral_tegmental_area] synonym: "ventromedial mesencephalic tegmentum development" RELATED [GOC:TermGenie] synonym: "VTA development" BROAD [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030901 ! midbrain development created_by: bf creation_date: 2015-12-17T14:44:18Z [Term] id: GO:1904867 name: protein localization to Cajal body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "protein localization in Cajal body" EXACT [GOC:TermGenie] is_a: GO:1903405 ! protein localization to nuclear body created_by: tb creation_date: 2015-12-17T21:48:18Z [Term] id: GO:1904868 name: telomerase catalytic core complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex." [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "TERT-TERC complex formation" RELATED [GOC:TermGenie] is_a: GO:1905323 ! telomerase holoenzyme complex assembly created_by: rph creation_date: 2015-12-18T10:02:45Z [Term] id: GO:1904869 name: regulation of protein localization to Cajal body namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904867 ! protein localization to Cajal body relationship: regulates GO:1904867 ! protein localization to Cajal body created_by: nc creation_date: 2015-12-18T11:17:31Z [Term] id: GO:1904870 name: negative regulation of protein localization to Cajal body namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "down regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to Cajal body" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in Cajal body" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to Cajal body" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in Cajal body" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to Cajal body" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904869 ! regulation of protein localization to Cajal body intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904867 ! protein localization to Cajal body relationship: negatively_regulates GO:1904867 ! protein localization to Cajal body created_by: nc creation_date: 2015-12-18T11:17:38Z [Term] id: GO:1904871 name: positive regulation of protein localization to Cajal body namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "activation of protein localisation in Cajal body" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to Cajal body" NARROW [GOC:TermGenie] synonym: "activation of protein localization in Cajal body" NARROW [GOC:TermGenie] synonym: "activation of protein localization to Cajal body" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in Cajal body" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to Cajal body" EXACT [GOC:TermGenie] is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904869 ! regulation of protein localization to Cajal body intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904867 ! protein localization to Cajal body relationship: positively_regulates GO:1904867 ! protein localization to Cajal body created_by: nc creation_date: 2015-12-18T11:17:45Z [Term] id: GO:1904872 name: regulation of telomerase RNA localization to Cajal body namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090671 ! telomerase RNA localization to Cajal body relationship: regulates GO:0090671 ! telomerase RNA localization to Cajal body created_by: nc creation_date: 2015-12-18T11:28:20Z [Term] id: GO:1904873 name: negative regulation of telomerase RNA localization to Cajal body namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "down regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] synonym: "down-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] synonym: "downregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] synonym: "inhibition of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body relationship: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body created_by: nc creation_date: 2015-12-18T11:28:27Z [Term] id: GO:1904874 name: positive regulation of telomerase RNA localization to Cajal body namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] synonym: "activation of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie] synonym: "up regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] synonym: "up-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] synonym: "upregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body relationship: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body created_by: nc creation_date: 2015-12-18T11:28:34Z [Term] id: GO:1904875 name: regulation of DNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] is_a: GO:0051105 ! regulation of DNA ligation is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003909 ! DNA ligase activity relationship: regulates GO:0003909 ! DNA ligase activity created_by: rl creation_date: 2015-12-18T18:35:30Z [Term] id: GO:1904876 name: negative regulation of DNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] synonym: "down regulation of DNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA ligase activity" EXACT [GOC:TermGenie] synonym: "inhibition of DNA ligase activity" NARROW [GOC:TermGenie] is_a: GO:0051107 ! negative regulation of DNA ligation is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:1904875 ! regulation of DNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003909 ! DNA ligase activity relationship: negatively_regulates GO:0003909 ! DNA ligase activity created_by: rl creation_date: 2015-12-18T18:35:37Z [Term] id: GO:1904877 name: positive regulation of DNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] synonym: "activation of DNA ligase activity" NARROW [GOC:TermGenie] synonym: "up regulation of DNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA ligase activity" EXACT [GOC:TermGenie] is_a: GO:0051106 ! positive regulation of DNA ligation is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:1904875 ! regulation of DNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003909 ! DNA ligase activity relationship: positively_regulates GO:0003909 ! DNA ligase activity created_by: rl creation_date: 2015-12-18T18:35:44Z [Term] id: GO:1904878 name: negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515] synonym: "down regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] synonym: "downregulation of generation of L-type calcium current" EXACT [GOC:TermGenie] synonym: "inhibition of generation of L-type calcium current" NARROW [GOC:TermGenie] synonym: "negative regulation of generation of L-type calcium current" RELATED [] is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel relationship: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel created_by: sl creation_date: 2015-12-18T22:30:37Z [Term] id: GO:1904879 name: positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515] synonym: "activation of generation of L-type calcium current" NARROW [GOC:TermGenie] synonym: "positive regulation of generation of L-type calcium current" RELATED [] synonym: "up regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] synonym: "upregulation of generation of L-type calcium current" EXACT [GOC:TermGenie] is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel relationship: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel created_by: sl creation_date: 2015-12-18T22:30:44Z [Term] id: GO:1904880 name: response to hydrogen sulfide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] synonym: "response to dihydridosulfur" EXACT [] synonym: "response to sulfane" EXACT [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009636 ! response to toxic substance is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2016-01-04T23:56:27Z [Term] id: GO:1904881 name: cellular response to hydrogen sulfide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] synonym: "cellular response to dihydridosulfur" EXACT [] synonym: "cellular response to sulfane" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904880 ! response to hydrogen sulfide created_by: sl creation_date: 2016-01-04T23:56:35Z [Term] id: GO:1904882 name: regulation of telomerase catalytic core complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904868 ! telomerase catalytic core complex assembly relationship: regulates GO:1904868 ! telomerase catalytic core complex assembly created_by: rph creation_date: 2016-01-05T10:36:01Z [Term] id: GO:1904883 name: negative regulation of telomerase catalytic core complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "down regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "down regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "down-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "downregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "downregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "inhibition of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of telomerase catalytic core complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "inhibition of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "negative regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly relationship: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly created_by: rph creation_date: 2016-01-05T10:36:09Z [Term] id: GO:1904884 name: positive regulation of telomerase catalytic core complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "activation of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie] synonym: "activation of telomerase catalytic core complex formation" NARROW [GOC:TermGenie] synonym: "activation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "activation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "positive regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "up regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "up regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "up-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] synonym: "upregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] synonym: "upregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly relationship: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly created_by: rph creation_date: 2016-01-05T10:36:16Z [Term] id: GO:1904885 name: beta-catenin destruction complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17143292, PMID:23169527] synonym: "23S APC complex assembly" NARROW [GOC:TermGenie] synonym: "23S APC complex formation" NARROW [GOC:TermGenie] synonym: "APC-Axin-1-beta-catenin complex assembly" EXACT [GOC:TermGenie] synonym: "APC-Axin-1-beta-catenin complex formation" EXACT [GOC:TermGenie] synonym: "Axin-APC-beta-catenin-GSK3B complex assembly" EXACT [GOC:TermGenie] synonym: "Axin-APC-beta-catenin-GSK3B complex formation" EXACT [GOC:TermGenie] synonym: "BDC assembly" EXACT [GOC:TermGenie] synonym: "BDC formation" EXACT [GOC:TermGenie] synonym: "beta-catenin degradation complex assembly" EXACT [GOC:TermGenie] synonym: "beta-catenin degradation complex formation" EXACT [GOC:TermGenie] synonym: "beta-catenin destruction complex formation" EXACT [GOC:TermGenie] synonym: "destruction complex formation" RELATED [PMID:23169527] is_a: GO:0065003 ! protein-containing complex assembly created_by: bf creation_date: 2016-01-05T11:40:55Z [Term] id: GO:1904886 name: beta-catenin destruction complex disassembly namespace: biological_process def: "The disaggregation of a beta-catenin destruction complex into its constituent components." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23169527] synonym: "23S APC complex disassembly" NARROW [GOC:TermGenie] synonym: "APC-Axin-1-beta-catenin complex disassembly" EXACT [GOC:TermGenie] synonym: "Axin-APC-beta-catenin-GSK3B complex disassembly" EXACT [GOC:TermGenie] synonym: "BDC disassembly" EXACT [GOC:TermGenie] synonym: "beta-catenin degradation complex disassembly" EXACT [GOC:TermGenie] synonym: "dissociation of beta-catenin degradation complex" EXACT [GOC:bf, PMID:17318175] is_a: GO:0032984 ! protein-containing complex disassembly relationship: part_of GO:0060070 ! canonical Wnt signaling pathway created_by: bf creation_date: 2016-01-05T11:41:02Z [Term] id: GO:1904887 name: Wnt signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650] synonym: "LRP5/6 signalosome assembly" EXACT [GOC:TermGenie] synonym: "LRP5/6 signalosome formation" EXACT [GOC:TermGenie] synonym: "LRP6 signalosome assembly" NARROW [GOC:TermGenie] synonym: "LRP6 signalosome formation" NARROW [GOC:TermGenie] synonym: "Wnt signalosome complex assembly" EXACT [GOC:TermGenie] synonym: "Wnt signalosome complex formation" EXACT [GOC:TermGenie] synonym: "Wnt signalosome formation" EXACT [GOC:TermGenie] synonym: "Wnt-LRP5/6 signalosome assembly" EXACT [GOC:TermGenie] synonym: "Wnt-LRP5/6 signalosome formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: bf creation_date: 2016-01-05T15:34:36Z [Term] id: GO:1904888 name: cranial skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227] synonym: "cranial skeleton development" NARROW [GOC:TermGenie] synonym: "craniofacial development" NARROW [PMID:11262227] synonym: "cranium development" RELATED [GOC:TermGenie] synonym: "osteocranium development" NARROW [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: bf creation_date: 2016-01-07T13:45:06Z [Term] id: GO:1904889 name: regulation of excitatory synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904861 ! excitatory synapse assembly relationship: regulates GO:1904861 ! excitatory synapse assembly created_by: bf creation_date: 2016-01-07T14:35:53Z [Term] id: GO:1904890 name: negative regulation of excitatory synapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "inhibition of excitatory synapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of excitatory synapse formation" NARROW [GOC:TermGenie] synonym: "negative regulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1904889 ! regulation of excitatory synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904861 ! excitatory synapse assembly relationship: negatively_regulates GO:1904861 ! excitatory synapse assembly created_by: bf creation_date: 2016-01-07T14:36:00Z [Term] id: GO:1904891 name: positive regulation of excitatory synapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] synonym: "activation of excitatory synapse assembly" NARROW [GOC:TermGenie] synonym: "activation of excitatory synapse formation" NARROW [GOC:TermGenie] synonym: "positive regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "up regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "up-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] synonym: "upregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of excitatory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051965 ! positive regulation of synapse assembly is_a: GO:1904889 ! regulation of excitatory synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904861 ! excitatory synapse assembly relationship: positively_regulates GO:1904861 ! excitatory synapse assembly created_by: bf creation_date: 2016-01-07T14:36:07Z [Term] id: GO:1904892 name: regulation of receptor signaling pathway via STAT namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] synonym: "regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "regulation of STAT signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097696 ! receptor signaling pathway via STAT relationship: regulates GO:0097696 ! receptor signaling pathway via STAT created_by: pr creation_date: 2016-01-08T08:14:33Z [Term] id: GO:1904893 name: negative regulation of receptor signaling pathway via STAT namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] synonym: "down regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "down regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "down regulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "down regulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "downregulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "downregulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "downregulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of kinase activated-STAT cascade" NARROW [GOC:TermGenie] synonym: "inhibition of kinase-STAT cascade" NARROW [GOC:TermGenie] synonym: "inhibition of STAT cascade" NARROW [GOC:TermGenie] synonym: "inhibition of STAT signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of STAT signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097696 ! receptor signaling pathway via STAT relationship: negatively_regulates GO:0097696 ! receptor signaling pathway via STAT created_by: pr creation_date: 2016-01-08T08:14:41Z [Term] id: GO:1904894 name: positive regulation of receptor signaling pathway via STAT namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] synonym: "activation of kinase activated-STAT cascade" NARROW [GOC:TermGenie] synonym: "activation of kinase-STAT cascade" NARROW [GOC:TermGenie] synonym: "activation of STAT cascade" NARROW [GOC:TermGenie] synonym: "activation of STAT signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "positive regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "positive regulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "up regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "up regulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "up regulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of STAT signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] synonym: "upregulation of kinase-STAT cascade" EXACT [GOC:TermGenie] synonym: "upregulation of STAT cascade" EXACT [GOC:TermGenie] synonym: "upregulation of STAT signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097696 ! receptor signaling pathway via STAT relationship: positively_regulates GO:0097696 ! receptor signaling pathway via STAT created_by: pr creation_date: 2016-01-08T08:14:48Z [Term] id: GO:1904895 name: ESCRT complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109] synonym: "endosomal sorting complex required for transport assembly" EXACT [GOC:TermGenie] synonym: "endosomal sorting complex required for transport formation" EXACT [GOC:TermGenie] synonym: "ESCRT complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: pad creation_date: 2016-01-12T10:27:11Z [Term] id: GO:1904896 name: ESCRT complex disassembly namespace: biological_process def: "The disaggregation of an ESCRT complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109] synonym: "endosomal sorting complex required for transport disassembly" EXACT [GOC:TermGenie] is_a: GO:0032984 ! protein-containing complex disassembly created_by: pad creation_date: 2016-01-12T10:27:30Z [Term] id: GO:1904897 name: regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990922 ! hepatic stellate cell proliferation relationship: regulates GO:1990922 ! hepatic stellate cell proliferation created_by: sl creation_date: 2016-01-14T15:56:59Z [Term] id: GO:1904898 name: negative regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "down regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of Ito cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048147 ! negative regulation of fibroblast proliferation is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation relationship: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation created_by: sl creation_date: 2016-01-14T15:57:06Z [Term] id: GO:1904899 name: positive regulation of hepatic stellate cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] synonym: "activation of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of Ito cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of Ito cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0048146 ! positive regulation of fibroblast proliferation is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990922 ! hepatic stellate cell proliferation relationship: positively_regulates GO:1990922 ! hepatic stellate cell proliferation created_by: sl creation_date: 2016-01-14T15:57:13Z [Term] id: GO:1904900 name: negative regulation of myosin II filament organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "down regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "down regulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "down regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "down-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "down-regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "down-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "downregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "downregulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "downregulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "downregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "inhibition of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "inhibition of myosin II filament organisation" NARROW [GOC:TermGenie] synonym: "inhibition of myosin II filament organization" NARROW [GOC:TermGenie] synonym: "inhibition of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "negative regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "negative regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] is_a: GO:0043519 ! regulation of myosin II filament organization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031038 ! myosin II filament organization relationship: negatively_regulates GO:0031038 ! myosin II filament organization created_by: mec creation_date: 2016-01-15T09:04:54Z [Term] id: GO:1904901 name: positive regulation of myosin II filament organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "activation of myosin II filament organisation" NARROW [GOC:TermGenie] synonym: "activation of myosin II filament organization" NARROW [GOC:TermGenie] synonym: "activation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "positive regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "positive regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "up regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "up regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "up regulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "up regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "up-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "up-regulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "up-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] synonym: "upregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] synonym: "upregulation of myosin II filament organisation" EXACT [GOC:TermGenie] synonym: "upregulation of myosin II filament organization" EXACT [GOC:TermGenie] synonym: "upregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] is_a: GO:0043519 ! regulation of myosin II filament organization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031038 ! myosin II filament organization relationship: positively_regulates GO:0031038 ! myosin II filament organization created_by: mec creation_date: 2016-01-15T09:05:02Z [Term] id: GO:1904902 name: ESCRT III complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296] synonym: "ESCRT III complex formation" EXACT [GOC:TermGenie] is_a: GO:1904895 ! ESCRT complex assembly created_by: pad creation_date: 2016-01-18T13:38:07Z [Term] id: GO:1904903 name: ESCRT III complex disassembly namespace: biological_process def: "The disaggregation of an ESCRT III complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296] is_a: GO:1904896 ! ESCRT complex disassembly created_by: pad creation_date: 2016-01-18T13:38:14Z [Term] id: GO:1904904 name: regulation of endothelial cell-matrix adhesion via fibronectin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] is_a: GO:0001952 ! regulation of cell-matrix adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin relationship: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin created_by: bc creation_date: 2016-01-19T10:23:01Z [Term] id: GO:1904905 name: negative regulation of endothelial cell-matrix adhesion via fibronectin namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] synonym: "down regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie] is_a: GO:0001953 ! negative regulation of cell-matrix adhesion is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin relationship: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin created_by: bc creation_date: 2016-01-19T10:23:09Z [Term] id: GO:1904906 name: positive regulation of endothelial cell-matrix adhesion via fibronectin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] synonym: "activation of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] is_a: GO:0001954 ! positive regulation of cell-matrix adhesion is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin relationship: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin created_by: bc creation_date: 2016-01-19T10:23:16Z [Term] id: GO:1904907 name: regulation of maintenance of mitotic sister chromatid cohesion, telomeric namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] synonym: "regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric relationship: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric created_by: rph creation_date: 2016-01-19T10:30:29Z [Term] id: GO:1904908 name: negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] synonym: "down regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "inhibition of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie] synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "negative regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric relationship: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric created_by: rph creation_date: 2016-01-19T10:30:36Z [Term] id: GO:1904909 name: positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] synonym: "activation of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie] synonym: "activation of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie] synonym: "activation of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie] synonym: "activation of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie] synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric relationship: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric created_by: rph creation_date: 2016-01-19T10:30:43Z [Term] id: GO:1904910 name: regulation of establishment of RNA localization to telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097694 ! establishment of RNA localization to telomere relationship: regulates GO:0097694 ! establishment of RNA localization to telomere created_by: rph creation_date: 2016-01-19T10:34:21Z [Term] id: GO:1904911 name: negative regulation of establishment of RNA localization to telomere namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "down regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of RNA localization to telomere" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere relationship: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere created_by: rph creation_date: 2016-01-19T10:34:28Z [Term] id: GO:1904912 name: positive regulation of establishment of RNA localization to telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "activation of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie] synonym: "activation of establishment of RNA localization to telomere" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097694 ! establishment of RNA localization to telomere relationship: positively_regulates GO:0097694 ! establishment of RNA localization to telomere created_by: rph creation_date: 2016-01-19T10:34:35Z [Term] id: GO:1904913 name: regulation of establishment of protein-containing complex localization to telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "regulation of establishment of macromolecular complex localization to telomere" RELATED [] is_a: GO:0070203 ! regulation of establishment of protein localization to telomere intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097695 ! establishment of protein-containing complex localization to telomere relationship: regulates GO:0097695 ! establishment of protein-containing complex localization to telomere created_by: rph creation_date: 2016-01-19T10:38:22Z [Term] id: GO:1904914 name: negative regulation of establishment of protein-containing complex localization to telomere namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "down regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of macromolecular complex localization to telomere" RELATED [] is_a: GO:1904850 ! negative regulation of establishment of protein localization to telomere is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere relationship: negatively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere created_by: rph creation_date: 2016-01-19T10:38:29Z [Term] id: GO:1904915 name: positive regulation of establishment of protein-containing complex localization to telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] synonym: "activation of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie] synonym: "activation of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of macromolecular complex localization to telomere" RELATED [] synonym: "up regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] is_a: GO:1904851 ! positive regulation of establishment of protein localization to telomere is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere relationship: positively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere created_by: rph creation_date: 2016-01-19T10:38:36Z [Term] id: GO:1904916 name: transmembrane L-lysine transport from lysosomal lumen to cytosol namespace: biological_process def: "The directed movement of L-lysine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0007041 ! lysosomal transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:1903401 ! L-lysine transmembrane transport created_by: kmv creation_date: 2016-01-21T16:27:41Z [Term] id: GO:1904917 name: L-arginine transmembrane transport from lysosomal lumen to cytosol namespace: biological_process def: "The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] synonym: "transmembrane L-arginine transport from lysosomal lumen to cytosol" EXACT [] is_a: GO:0007041 ! lysosomal transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:1903400 ! L-arginine transmembrane transport created_by: kmv creation_date: 2016-01-21T16:27:48Z [Term] id: GO:1904918 name: transmembrane L-histidine transport from lysosomal lumen to cytosol namespace: biological_process def: "The directed movement of L-histidine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0007041 ! lysosomal transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0089709 ! L-histidine transmembrane transport created_by: kmv creation_date: 2016-01-21T16:27:55Z [Term] id: GO:1904919 name: transmembrane L-cystine transport from lysosomal lumen to cytosol namespace: biological_process def: "The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0007041 ! lysosomal transport is_a: GO:0015811 ! L-cystine transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: kmv creation_date: 2016-01-21T16:28:02Z [Term] id: GO:1904920 name: regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0048679 ! regulation of axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:35Z [Term] id: GO:1904921 name: negative regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "down regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "down-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "down-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "downregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "downregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "downregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "downregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "inhibition of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "inhibition of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "negative regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "negative regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "negative regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: negatively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:42Z [Term] id: GO:1904922 name: positive regulation of MAPK cascade involved in axon regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] synonym: "activation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "activation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "activation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "activation of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "positive regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "positive regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "positive regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "up-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "upregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "upregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] synonym: "upregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "upregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:1904920 ! regulation of MAPK cascade involved in axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration relationship: positively_regulates GO:1903616 ! MAPK cascade involved in axon regeneration created_by: kmv creation_date: 2016-01-25T17:03:49Z [Term] id: GO:1904923 name: regulation of autophagy of mitochondrion in response to mitochondrial depolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] is_a: GO:0098780 ! response to mitochondrial depolarisation is_a: GO:1903146 ! regulation of autophagy of mitochondrion intersection_of: GO:0098780 ! response to mitochondrial depolarisation intersection_of: regulates GO:0000422 ! autophagy of mitochondrion created_by: pad creation_date: 2016-01-26T11:23:50Z [Term] id: GO:1904924 name: negative regulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] synonym: "down regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] is_a: GO:1901525 ! negative regulation of mitophagy is_a: GO:1904923 ! regulation of autophagy of mitochondrion in response to mitochondrial depolarization intersection_of: GO:0098780 ! response to mitochondrial depolarisation intersection_of: negatively_regulates GO:0000423 ! mitophagy created_by: pad creation_date: 2016-01-26T11:23:58Z [Term] id: GO:1904925 name: positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] synonym: "activation of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] synonym: "up regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] is_a: GO:1903599 ! positive regulation of autophagy of mitochondrion is_a: GO:1904923 ! regulation of autophagy of mitochondrion in response to mitochondrial depolarization intersection_of: GO:0098780 ! response to mitochondrial depolarisation intersection_of: positively_regulates GO:0000422 ! autophagy of mitochondrion created_by: pad creation_date: 2016-01-26T11:24:05Z [Term] id: GO:1904926 name: response to palmitoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233] is_a: GO:0070542 ! response to fatty acid created_by: mr creation_date: 2016-01-27T23:07:22Z [Term] id: GO:1904927 name: cellular response to palmitoleic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:1904926 ! response to palmitoleic acid created_by: mr creation_date: 2016-01-27T23:07:31Z [Term] id: GO:1904928 name: coreceptor activity involved in canonical Wnt signaling pathway namespace: molecular_function def: "Any coreceptor activity that is involved in a canonical Wnt signaling pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "coreceptor activity involved in canonical Wnt receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in canonical Wnt-activated signaling pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in frizzled-1 receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie] synonym: "Wnt co-receptor activity, canonical signaling" EXACT [GOC:bf] synonym: "Wnt co-receptor, canonical pathway" EXACT [GOC:bf] is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway intersection_of: GO:0015026 ! coreceptor activity intersection_of: part_of GO:0060070 ! canonical Wnt signaling pathway relationship: part_of GO:0060070 ! canonical Wnt signaling pathway created_by: bf creation_date: 2016-01-28T15:14:46Z [Term] id: GO:1904929 name: coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway namespace: molecular_function def: "Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "coreceptor activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor activity involved in PCP pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in planar cell polarity pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] synonym: "coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] synonym: "Wnt co-receptor activity, non-canonical signaling" BROAD [GOC:bf] synonym: "Wnt co-receptor, non-canonical pathway" BROAD [GOC:bf] synonym: "Wnt/PCP co-receptor activity" EXACT [PMID:24431302] is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway intersection_of: GO:0015026 ! coreceptor activity intersection_of: part_of GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: part_of GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway created_by: bf creation_date: 2016-01-28T15:15:01Z [Term] id: GO:1904930 name: amphisome membrane namespace: cellular_component def: "Any membrane that is part of an amphisome." [GO_REF:0000064, GOC:bhm, GOC:TermGenie, PMID:17984323] is_a: GO:0000421 ! autophagosome membrane created_by: pr creation_date: 2016-01-29T11:40:13Z [Term] id: GO:1904931 name: MCM complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an MCM complex." [GO_REF:000102, GOC:TermGenie, PMID:12604790] synonym: "mini-chromosome maintenance complex binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: mah creation_date: 2016-01-29T11:48:10Z [Term] id: GO:1904932 name: negative regulation of cartilage condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17604018] synonym: "down regulation of cartilage condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of cartilage condensation" EXACT [GOC:TermGenie] synonym: "downregulation of cartilage condensation" EXACT [GOC:TermGenie] synonym: "inhibition of cartilage condensation" NARROW [GOC:TermGenie] is_a: GO:0061037 ! negative regulation of cartilage development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1902026 ! regulation of cartilage condensation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001502 ! cartilage condensation relationship: negatively_regulates GO:0001502 ! cartilage condensation created_by: mr creation_date: 2016-01-29T18:13:39Z [Term] id: GO:1904933 name: regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033278 ! cell proliferation in midbrain relationship: regulates GO:0033278 ! cell proliferation in midbrain created_by: bf creation_date: 2016-02-01T13:16:11Z [Term] id: GO:1904934 name: negative regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033278 ! cell proliferation in midbrain relationship: negatively_regulates GO:0033278 ! cell proliferation in midbrain created_by: bf creation_date: 2016-02-01T13:16:19Z [Term] id: GO:1904935 name: positive regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033278 ! cell proliferation in midbrain relationship: positively_regulates GO:0033278 ! cell proliferation in midbrain created_by: bf creation_date: 2016-02-01T13:16:27Z [Term] id: GO:1904936 name: interneuron migration namespace: biological_process def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] synonym: "inter neuron migration" EXACT [GOC:ah] synonym: "inter-neuron migration" EXACT [GOC:ah] is_a: GO:0001764 ! neuron migration created_by: ah creation_date: 2016-02-01T14:04:32Z [Term] id: GO:1904937 name: sensory neuron migration namespace: biological_process def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] is_a: GO:0001764 ! neuron migration created_by: ah creation_date: 2016-02-01T14:15:50Z [Term] id: GO:1904938 name: planar cell polarity pathway involved in axon guidance namespace: biological_process def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308] synonym: "non-canonical Wnt signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] synonym: "PCP pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "PCP pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "PCP pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:bf] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling involved in axon guidance" EXACT [GOC:bf] synonym: "Wnt-PCP signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance created_by: bf creation_date: 2016-02-02T14:46:26Z [Term] id: GO:1904939 name: regulation of DNA nucleotidylexotransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "regulation of addase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of TdT" RELATED [GOC:TermGenie] synonym: "regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of terminal transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003912 ! DNA nucleotidylexotransferase activity relationship: regulates GO:0003912 ! DNA nucleotidylexotransferase activity created_by: bc creation_date: 2016-02-02T15:15:57Z [Term] id: GO:1904940 name: negative regulation of DNA nucleotidylexotransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "down regulation of addase activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of TdT" RELATED [GOC:TermGenie] synonym: "down regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "down regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of addase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of TdT" RELATED [GOC:TermGenie] synonym: "down-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "down-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of addase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of TdT" RELATED [GOC:TermGenie] synonym: "downregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "downregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of addase activity" NARROW [GOC:TermGenie] synonym: "inhibition of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of TdT" RELATED [GOC:TermGenie] synonym: "inhibition of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "inhibition of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of terminal transferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of addase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of TdT" RELATED [GOC:TermGenie] synonym: "negative regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "negative regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of terminal transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity relationship: negatively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity created_by: bc creation_date: 2016-02-02T15:16:05Z [Term] id: GO:1904941 name: positive regulation of DNA nucleotidylexotransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "activation of addase activity" NARROW [GOC:TermGenie] synonym: "activation of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie] synonym: "activation of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of TdT" RELATED [GOC:TermGenie] synonym: "activation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "activation of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie] synonym: "activation of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of terminal transferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of addase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of TdT" RELATED [GOC:TermGenie] synonym: "positive regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "positive regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of addase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of TdT" RELATED [GOC:TermGenie] synonym: "up regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "up regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of addase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of TdT" RELATED [GOC:TermGenie] synonym: "up-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "up-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of terminal transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of addase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of TdT" RELATED [GOC:TermGenie] synonym: "upregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] synonym: "upregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of terminal transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity relationship: positively_regulates GO:0003912 ! DNA nucleotidylexotransferase activity created_by: bc creation_date: 2016-02-02T15:16:12Z [Term] id: GO:1904942 name: regulation of cardiac ventricle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003211 ! cardiac ventricle formation relationship: regulates GO:0003211 ! cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:16Z [Term] id: GO:1904943 name: negative regulation of cardiac ventricle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie] is_a: GO:1901211 ! negative regulation of cardiac chamber formation is_a: GO:1904413 ! negative regulation of cardiac ventricle development is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003211 ! cardiac ventricle formation relationship: negatively_regulates GO:0003211 ! cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:24Z [Term] id: GO:1904944 name: positive regulation of cardiac ventricle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] is_a: GO:1901212 ! positive regulation of cardiac chamber formation is_a: GO:1904414 ! positive regulation of cardiac ventricle development is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003211 ! cardiac ventricle formation relationship: positively_regulates GO:0003211 ! cardiac ventricle formation created_by: bc creation_date: 2016-02-02T16:37:31Z [Term] id: GO:1904945 name: obsolete response to cobalt(II) acetate namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: mr creation_date: 2016-02-02T16:47:52Z [Term] id: GO:1904946 name: obsolete cellular response to cobalt(II) acetate namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: mr creation_date: 2016-02-02T16:48:00Z [Term] id: GO:1904947 name: folate import into mitochondrion namespace: biological_process def: "The process in which folic acid is transported from the cytosol, into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890] synonym: "folic acid import into mitochondrion" RELATED [] is_a: GO:0098838 ! folate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: rph creation_date: 2016-02-03T12:10:14Z [Term] id: GO:1904948 name: midbrain dopaminergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665] synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665] synonym: "mDA neuron differentiation" EXACT [PMID:24287202] synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665] synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665] is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0071542 ! dopaminergic neuron differentiation relationship: part_of GO:0030901 ! midbrain development created_by: bf creation_date: 2016-02-04T14:38:10Z [Term] id: GO:1904949 name: ATPase complex namespace: cellular_component def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). synonym: "VPS4 complex" NARROW [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-02-04T22:13:32Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization relationship: negatively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045184 ! establishment of protein localization relationship: positively_regulates GO:0045184 ! establishment of protein localization created_by: mec creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1904952 name: hydroxycinnamic acid transport namespace: biological_process def: "The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26744218] is_a: GO:0015718 ! monocarboxylic acid transport created_by: lr creation_date: 2016-02-05T22:00:38Z [Term] id: GO:1904953 name: Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250, PMID:22988876, PMID:23517308] synonym: "frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "Wnt-mediated midbrain DA neuron differentiation" EXACT [PMID:23517308] is_a: GO:0016055 ! Wnt signaling pathway intersection_of: GO:0016055 ! Wnt signaling pathway intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation relationship: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-08T12:02:07Z [Term] id: GO:1904954 name: canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876] synonym: "canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "canonical Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:bf] synonym: "frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:0060070 ! canonical Wnt signaling pathway is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-09T11:04:46Z [Term] id: GO:1904955 name: planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876] synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" BROAD [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" BROAD [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" BROAD [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" BROAD [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" BROAD [GOC:TermGenie] synonym: "non-canonical Wnt-mediated midbrain DA neuron differentiation" BROAD [GOC:bf] synonym: "PCP pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "PCP pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [] synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:1905438 ! non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation intersection_of: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-09T11:04:56Z [Term] id: GO:1904956 name: regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation relationship: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-09T12:00:21Z [Term] id: GO:1904957 name: negative regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation relationship: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-09T12:00:29Z [Term] id: GO:1904958 name: positive regulation of midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation relationship: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-02-09T12:00:36Z [Term] id: GO:1904959 name: regulation of cytochrome-c oxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017] synonym: "regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1904732 ! regulation of electron transfer activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004129 ! cytochrome-c oxidase activity relationship: regulates GO:0004129 ! cytochrome-c oxidase activity created_by: tb creation_date: 2016-02-09T22:18:27Z [Term] id: GO:1904960 name: positive regulation of cytochrome-c oxidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017] synonym: "activation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "activation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "activation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "activation of cytochrome c oxidase activity" NARROW [GOC:TermGenie] synonym: "activation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "activation of cytochrome-c oxidase activity" NARROW [GOC:TermGenie] synonym: "activation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "activation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "activation of indophenolase" NARROW [GOC:TermGenie] synonym: "activation of NADH cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "activation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "positive regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "positive regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "positive regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "positive regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "positive regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "positive regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "positive regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "up regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "up regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "up regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "up regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "up regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "up regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "up regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "up regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "up regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "up-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "up-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "up-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "up-regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "up-regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "up-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "up-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "upregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "upregulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "upregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "upregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "upregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "upregulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "upregulation of indophenolase" NARROW [GOC:TermGenie] synonym: "upregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "upregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1904734 ! positive regulation of electron transfer activity is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004129 ! cytochrome-c oxidase activity relationship: positively_regulates GO:0004129 ! cytochrome-c oxidase activity created_by: tb creation_date: 2016-02-09T22:18:43Z [Term] id: GO:1904961 name: quiescent center organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure." [GO_REF:0000084, GOC:TermGenie, PMID:21233333] synonym: "quiescent center structural organization" EXACT [] is_a: GO:0048532 ! anatomical structure arrangement created_by: tb creation_date: 2016-02-10T00:11:00Z [Term] id: GO:1904962 name: plastid to vacuole vesicle-mediated transport namespace: biological_process def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689] synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport created_by: tb creation_date: 2016-02-10T00:14:48Z [Term] id: GO:1904963 name: regulation of phytol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650] synonym: "regulation of phytol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of phytol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of phytol formation" EXACT [GOC:TermGenie] synonym: "regulation of phytol synthesis" EXACT [GOC:TermGenie] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033520 ! phytol biosynthetic process relationship: regulates GO:0033520 ! phytol biosynthetic process created_by: tb creation_date: 2016-02-11T00:41:51Z [Term] id: GO:1904964 name: positive regulation of phytol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650] synonym: "activation of phytol anabolism" NARROW [GOC:TermGenie] synonym: "activation of phytol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of phytol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of phytol formation" NARROW [GOC:TermGenie] synonym: "activation of phytol synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of phytol anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of phytol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of phytol formation" EXACT [GOC:TermGenie] synonym: "positive regulation of phytol synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phytol anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of phytol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phytol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of phytol formation" EXACT [GOC:TermGenie] synonym: "up regulation of phytol synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phytol anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of phytol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phytol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of phytol formation" EXACT [GOC:TermGenie] synonym: "up-regulation of phytol synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phytol anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of phytol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phytol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of phytol formation" EXACT [GOC:TermGenie] synonym: "upregulation of phytol synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process is_a: GO:1904963 ! regulation of phytol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033520 ! phytol biosynthetic process relationship: positively_regulates GO:0033520 ! phytol biosynthetic process created_by: tb creation_date: 2016-02-11T00:42:07Z [Term] id: GO:1904965 name: regulation of vitamin E biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244] synonym: "regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of vitamin E anabolism" EXACT [GOC:TermGenie] synonym: "regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of vitamin E formation" EXACT [GOC:TermGenie] synonym: "regulation of vitamin E synthesis" EXACT [GOC:TermGenie] is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010189 ! vitamin E biosynthetic process relationship: regulates GO:0010189 ! vitamin E biosynthetic process created_by: tb creation_date: 2016-02-12T17:56:55Z [Term] id: GO:1904966 name: positive regulation of vitamin E biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244] synonym: "activation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of vitamin E anabolism" NARROW [GOC:TermGenie] synonym: "activation of vitamin E biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of vitamin E biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of vitamin E formation" NARROW [GOC:TermGenie] synonym: "activation of vitamin E synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "positive regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin E anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin E formation" EXACT [GOC:TermGenie] synonym: "positive regulation of vitamin E synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "up regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin E anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin E formation" EXACT [GOC:TermGenie] synonym: "up regulation of vitamin E synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "up-regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "up-regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin E anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin E formation" EXACT [GOC:TermGenie] synonym: "up-regulation of vitamin E synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] synonym: "upregulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] synonym: "upregulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin E anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin E formation" EXACT [GOC:TermGenie] synonym: "upregulation of vitamin E synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046136 ! positive regulation of vitamin metabolic process is_a: GO:1904965 ! regulation of vitamin E biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010189 ! vitamin E biosynthetic process relationship: positively_regulates GO:0010189 ! vitamin E biosynthetic process created_by: tb creation_date: 2016-02-12T17:57:03Z [Term] id: GO:1904967 name: regulation of monopolar spindle attachment to meiosis I kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679] synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore is_a: GO:0060629 ! regulation of homologous chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore relationship: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore created_by: mah creation_date: 2016-02-15T15:19:12Z [Term] id: GO:1904968 name: positive regulation of monopolar spindle attachment to meiosis I kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679] synonym: "activation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" NARROW [GOC:TermGenie] synonym: "activation of attachment of spindle microtubules to kinetochore involved in meiosis I" NARROW [GOC:TermGenie] synonym: "activation of monopolar attachment" NARROW [GOC:TermGenie] synonym: "activation of sister kinetochore mono-orientation" NARROW [GOC:TermGenie] synonym: "positive regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "positive regulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "positive regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "up regulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "up regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "up-regulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "up-regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "upregulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "upregulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore is_a: GO:0060903 ! positive regulation of meiosis I is_a: GO:1904967 ! regulation of monopolar spindle attachment to meiosis I kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore relationship: positively_regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore created_by: mah creation_date: 2016-02-15T15:19:20Z [Term] id: GO:1904969 name: slow muscle cell migration namespace: biological_process def: "The orderly movement of a slow muscle cell from one site to another." [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553] comment: The directional migration of a slow muscle cell from one site to another within the embryo. synonym: "slow-twitch muscle cell migration" EXACT [PMID:14667409] is_a: GO:0110122 ! myotube cell migration created_by: ymb creation_date: 2016-02-16T21:20:11Z [Term] id: GO:1904970 name: brush border assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409] synonym: "brush border formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly created_by: tb creation_date: 2016-02-17T00:58:30Z [Term] id: GO:1904971 name: regulation of viral translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] synonym: "regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "regulation of viral protein synthesis" EXACT [GOC:TermGenie] is_a: GO:0050792 ! regulation of viral process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019081 ! viral translation relationship: regulates GO:0019081 ! viral translation created_by: bhm creation_date: 2016-02-17T15:52:59Z [Term] id: GO:1904972 name: negative regulation of viral translation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] synonym: "down regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "down regulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of viral translation" EXACT [GOC:TermGenie] synonym: "down-regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "down-regulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of viral translation" EXACT [GOC:TermGenie] synonym: "downregulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "downregulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of viral translation" EXACT [GOC:TermGenie] synonym: "inhibition of viral protein anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of viral protein biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of viral protein biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of viral protein formation" NARROW [GOC:TermGenie] synonym: "inhibition of viral protein synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of viral translation" NARROW [GOC:TermGenie] synonym: "negative regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "negative regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "negative regulation of viral protein synthesis" EXACT [GOC:TermGenie] is_a: GO:0048525 ! negative regulation of viral process is_a: GO:1904971 ! regulation of viral translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019081 ! viral translation relationship: negatively_regulates GO:0019081 ! viral translation created_by: bhm creation_date: 2016-02-17T15:53:08Z [Term] id: GO:1904973 name: positive regulation of viral translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] synonym: "activation of viral protein anabolism" NARROW [GOC:TermGenie] synonym: "activation of viral protein biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of viral protein biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of viral protein formation" NARROW [GOC:TermGenie] synonym: "activation of viral protein synthesis" NARROW [GOC:TermGenie] synonym: "activation of viral translation" NARROW [GOC:TermGenie] synonym: "positive regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "positive regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "positive regulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "up regulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of viral translation" EXACT [GOC:TermGenie] synonym: "up-regulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "up-regulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of viral translation" EXACT [GOC:TermGenie] synonym: "upregulation of viral protein anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of viral protein biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of viral protein formation" EXACT [GOC:TermGenie] synonym: "upregulation of viral protein synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of viral translation" EXACT [GOC:TermGenie] is_a: GO:0048524 ! positive regulation of viral process is_a: GO:1904971 ! regulation of viral translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019081 ! viral translation relationship: positively_regulates GO:0019081 ! viral translation created_by: bhm creation_date: 2016-02-17T15:53:15Z [Term] id: GO:1904974 name: heparanase complex namespace: cellular_component def: "A protein complex which is capable of heparanase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802] comment: An example of this is HPSE in human (Q9Y251) in PMID:12927802 (inferred from direct assay). synonym: "HEPS complex" EXACT [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-02-18T11:50:39Z [Term] id: GO:1904975 name: response to bleomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: mah creation_date: 2016-02-18T15:21:23Z [Term] id: GO:1904976 name: cellular response to bleomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1901653 ! cellular response to peptide is_a: GO:1904975 ! response to bleomycin created_by: mah creation_date: 2016-02-18T15:21:31Z [Term] id: GO:1904977 name: lymphatic endothelial cell migration namespace: biological_process def: "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel." [GO_REF:0000091, GOC:TermGenie, PMID:25745057] is_a: GO:0043542 ! endothelial cell migration relationship: part_of GO:0036303 ! lymph vessel morphogenesis created_by: dgh creation_date: 2016-02-18T20:49:43Z [Term] id: GO:1904978 name: regulation of endosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] synonym: "regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007032 ! endosome organization relationship: regulates GO:0007032 ! endosome organization created_by: pad creation_date: 2016-02-22T19:21:01Z [Term] id: GO:1904979 name: negative regulation of endosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] synonym: "down regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of endosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of endosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of endosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of endosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of endosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904978 ! regulation of endosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007032 ! endosome organization relationship: negatively_regulates GO:0007032 ! endosome organization created_by: pad creation_date: 2016-02-22T19:21:08Z [Term] id: GO:1904980 name: positive regulation of endosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] synonym: "activation of endosome organisation" NARROW [GOC:TermGenie] synonym: "activation of endosome organization" NARROW [GOC:TermGenie] synonym: "activation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of endosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of endosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of endosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of endosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904978 ! regulation of endosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007032 ! endosome organization relationship: positively_regulates GO:0007032 ! endosome organization created_by: pad creation_date: 2016-02-22T19:21:16Z [Term] id: GO:1904981 name: maltose transmembrane transport namespace: biological_process def: "The process in which maltose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464] is_a: GO:0015768 ! maltose transport is_a: GO:0034219 ! carbohydrate transmembrane transport created_by: vw creation_date: 2016-02-28T21:14:04Z [Term] id: GO:1904982 name: sucrose transmembrane transport namespace: biological_process def: "The process in which sucrose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464] is_a: GO:0015770 ! sucrose transport is_a: GO:0034219 ! carbohydrate transmembrane transport created_by: vw creation_date: 2016-02-28T21:16:51Z [Term] id: GO:1904983 name: glycine import into mitochondrion namespace: biological_process def: "The process in which glycine is transported from the cytosol, into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380] synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0043090 ! amino acid import is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2016-02-28T21:53:44Z [Term] id: GO:1904984 name: regulation of quinolinate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] synonym: "regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "regulation of quinolinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019805 ! quinolinate biosynthetic process relationship: regulates GO:0019805 ! quinolinate biosynthetic process created_by: bf creation_date: 2016-02-29T15:54:12Z [Term] id: GO:1904985 name: negative regulation of quinolinate biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] synonym: "down regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "down regulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "down-regulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "downregulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of quinolinate anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of quinolinate biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of quinolinate biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of quinolinate formation" NARROW [GOC:TermGenie] synonym: "inhibition of quinolinate synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "negative regulation of quinolinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1904984 ! regulation of quinolinate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019805 ! quinolinate biosynthetic process relationship: negatively_regulates GO:0019805 ! quinolinate biosynthetic process created_by: bf creation_date: 2016-02-29T15:54:21Z [Term] id: GO:1904986 name: positive regulation of quinolinate biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of quinolinate anabolism" NARROW [GOC:TermGenie] synonym: "activation of quinolinate biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of quinolinate biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of quinolinate formation" NARROW [GOC:TermGenie] synonym: "activation of quinolinate synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "positive regulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "up regulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "up-regulation of quinolinate synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of quinolinate anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of quinolinate formation" EXACT [GOC:TermGenie] synonym: "upregulation of quinolinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1904984 ! regulation of quinolinate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019805 ! quinolinate biosynthetic process relationship: positively_regulates GO:0019805 ! quinolinate biosynthetic process created_by: bf creation_date: 2016-02-29T15:54:29Z [Term] id: GO:1904987 name: regulation of endothelial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042118 ! endothelial cell activation relationship: regulates GO:0042118 ! endothelial cell activation created_by: bc creation_date: 2016-02-29T16:16:09Z [Term] id: GO:1904988 name: negative regulation of endothelial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042118 ! endothelial cell activation relationship: negatively_regulates GO:0042118 ! endothelial cell activation created_by: bc creation_date: 2016-02-29T16:16:18Z [Term] id: GO:1904989 name: positive regulation of endothelial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042118 ! endothelial cell activation relationship: positively_regulates GO:0042118 ! endothelial cell activation created_by: bc creation_date: 2016-02-29T16:16:25Z [Term] id: GO:1904990 name: regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] synonym: "regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway relationship: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway created_by: kmv creation_date: 2016-02-29T22:42:16Z [Term] id: GO:1904991 name: negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] synonym: "down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie] synonym: "inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie] synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway relationship: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway created_by: kmv creation_date: 2016-02-29T22:42:25Z [Term] id: GO:1904992 name: positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] synonym: "activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie] synonym: "activation of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie] synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:0060161 ! positive regulation of dopamine receptor signaling pathway is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway relationship: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway created_by: kmv creation_date: 2016-02-29T22:42:33Z [Term] id: GO:1904993 name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in positive regulation of G2/M transition of mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie, PMID:24728197] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie] synonym: "positive regulation of CDK activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "positive regulation of CDK activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie] synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2016-03-01T00:59:41Z [Term] id: GO:1904994 name: regulation of leukocyte adhesion to vascular endothelial cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell relationship: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell created_by: bc creation_date: 2016-03-01T10:59:00Z [Term] id: GO:1904995 name: negative regulation of leukocyte adhesion to vascular endothelial cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] synonym: "down regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie] is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell relationship: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell created_by: bc creation_date: 2016-03-01T10:59:08Z [Term] id: GO:1904996 name: positive regulation of leukocyte adhesion to vascular endothelial cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] synonym: "activation of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie] synonym: "up regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell relationship: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell created_by: bc creation_date: 2016-03-01T10:59:22Z [Term] id: GO:1904997 name: regulation of leukocyte adhesion to arterial endothelial cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell relationship: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell created_by: bc creation_date: 2016-03-01T11:04:49Z [Term] id: GO:1904998 name: negative regulation of leukocyte adhesion to arterial endothelial cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] synonym: "down regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie] is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell relationship: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell created_by: bc creation_date: 2016-03-01T11:04:57Z [Term] id: GO:1904999 name: positive regulation of leukocyte adhesion to arterial endothelial cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] synonym: "activation of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie] synonym: "up regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell relationship: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell created_by: bc creation_date: 2016-03-01T11:05:05Z [Term] id: GO:1905000 name: regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] is_a: GO:0060372 ! regulation of atrial cardiac muscle cell membrane repolarization is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential relationship: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential created_by: rph creation_date: 2016-03-01T13:28:05Z [Term] id: GO:1905001 name: negative regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "down regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "down regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "down regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "downregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrial repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "inhibition of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] is_a: GO:1903948 ! negative regulation of atrial cardiac muscle cell action potential is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential relationship: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential created_by: rph creation_date: 2016-03-01T13:28:13Z [Term] id: GO:1905002 name: positive regulation of membrane repolarization during atrial cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] synonym: "activation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "activation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "activation of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrial repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] synonym: "upregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1903949 ! positive regulation of atrial cardiac muscle cell action potential is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential relationship: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential created_by: rph creation_date: 2016-03-01T13:28:21Z [Term] id: GO:1905003 name: picolinic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166] synonym: "picolinate metabolism" EXACT [CHEBI:38184] synonym: "picolinic acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: bf creation_date: 2016-03-01T14:06:28Z [Term] id: GO:1905004 name: picolinic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166] synonym: "picolinate biosynthesis" EXACT [CHEBI:38184] synonym: "picolinate biosynthetic process" EXACT [CHEBI:38184] synonym: "picolinic acid anabolism" EXACT [GOC:TermGenie] synonym: "picolinic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "picolinic acid formation" EXACT [GOC:TermGenie] synonym: "picolinic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:1905003 ! picolinic acid metabolic process created_by: bf creation_date: 2016-03-01T14:06:35Z [Term] id: GO:1905005 name: regulation of epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation relationship: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation created_by: rl creation_date: 2016-03-01T15:38:39Z [Term] id: GO:1905006 name: negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie] is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation relationship: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation created_by: rl creation_date: 2016-03-01T15:38:47Z [Term] id: GO:1905007 name: positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "activation of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation relationship: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation created_by: rl creation_date: 2016-03-01T15:38:54Z [Term] id: GO:1905008 name: regulation of L-lysine import across plasma membrane namespace: biological_process alt_id: GO:0010805 def: "Any process that modulates the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] synonym: "regulation of L-lysine import into cell" EXACT [] synonym: "regulation of lysine import" BROAD [] synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097639 ! L-lysine import across plasma membrane relationship: regulates GO:0097639 ! L-lysine import across plasma membrane created_by: sl creation_date: 2016-03-02T00:15:49Z [Term] id: GO:1905009 name: negative regulation of L-lysine import across plasma membrane namespace: biological_process alt_id: GO:0010806 def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] synonym: "down regulation of L-lysine import into cell" EXACT [GOC:TermGenie] synonym: "down-regulation of L-lysine import into cell" EXACT [GOC:TermGenie] synonym: "downregulation of L-lysine import into cell" EXACT [GOC:TermGenie] synonym: "inhibition of L-lysine import into cell" NARROW [GOC:TermGenie] synonym: "negative regulation of L-lysine import into cell" EXACT [] synonym: "negative regulation of lysine import" BROAD [] synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane relationship: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane created_by: sl creation_date: 2016-03-02T00:15:57Z [Term] id: GO:1905010 name: positive regulation of L-lysine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] synonym: "activation of L-lysine import into cell" NARROW [GOC:TermGenie] synonym: "positive regulation of L-lysine import into cell" EXACT [] synonym: "up regulation of L-lysine import into cell" EXACT [GOC:TermGenie] synonym: "up-regulation of L-lysine import into cell" EXACT [GOC:TermGenie] synonym: "upregulation of L-lysine import into cell" EXACT [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097639 ! L-lysine import across plasma membrane relationship: positively_regulates GO:0097639 ! L-lysine import across plasma membrane created_by: sl creation_date: 2016-03-02T00:16:04Z [Term] id: GO:1905011 name: transmembrane phosphate ion transport from cytosol to vacuole namespace: biological_process alt_id: GO:0007037 def: "The directed movement of phosphate ions from the cytosol across the vacuolar membrane\nand into the vacuolar lumen." [GO_REF:0000078, GOC:TermGenie, PMID:26554016] synonym: "vacuolar phosphate transport" BROAD [] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0035435 ! phosphate ion transmembrane transport created_by: tb creation_date: 2016-03-03T00:34:12Z [Term] id: GO:1905012 name: regulation of 'de novo' NAD biosynthetic process from tryptophan namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:0090357 ! regulation of tryptophan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan relationship: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan created_by: bf creation_date: 2016-03-03T10:00:50Z [Term] id: GO:1905013 name: negative regulation of 'de novo' NAD biosynthetic process from tryptophan namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] synonym: "down regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "down regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "down-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "down-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "downregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "downregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "inhibition of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie] synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan relationship: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan created_by: bf creation_date: 2016-03-03T10:01:00Z [Term] id: GO:1905014 name: positive regulation of 'de novo' NAD biosynthetic process from tryptophan namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie] synonym: "activation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "positive regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "up regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "up regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "up-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0090358 ! positive regulation of tryptophan metabolic process is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan relationship: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan created_by: bf creation_date: 2016-03-03T10:01:10Z [Term] id: GO:1905015 name: regulation of isoleucine-tRNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004822 ! isoleucine-tRNA ligase activity relationship: regulates GO:0004822 ! isoleucine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:00:48Z [Term] id: GO:1905016 name: negative regulation of isoleucine-tRNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "down regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "inhibition of isoleucine translase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "negative regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004822 ! isoleucine-tRNA ligase activity relationship: negatively_regulates GO:0004822 ! isoleucine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:00:57Z [Term] id: GO:1905017 name: positive regulation of isoleucine-tRNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "activation of isoleucine translase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "positive regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucine translase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004822 ! isoleucine-tRNA ligase activity relationship: positively_regulates GO:0004822 ! isoleucine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:01:06Z [Term] id: GO:1905018 name: regulation of methionine-tRNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of MetRS activity" EXACT [GOC:TermGenie] is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004825 ! methionine-tRNA ligase activity relationship: regulates GO:0004825 ! methionine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:02:39Z [Term] id: GO:1905019 name: negative regulation of methionine-tRNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "down regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "inhibition of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of methionine translase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methionine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of MetRS activity" NARROW [GOC:TermGenie] synonym: "negative regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of MetRS activity" EXACT [GOC:TermGenie] is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004825 ! methionine-tRNA ligase activity relationship: negatively_regulates GO:0004825 ! methionine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:02:48Z [Term] id: GO:1905020 name: positive regulation of methionine-tRNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] synonym: "activation of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "activation of methionine translase activity" NARROW [GOC:TermGenie] synonym: "activation of methionine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of MetRS activity" NARROW [GOC:TermGenie] synonym: "positive regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of MetRS activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of methionine translase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of MetRS activity" EXACT [GOC:TermGenie] is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004825 ! methionine-tRNA ligase activity relationship: positively_regulates GO:0004825 ! methionine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:02:57Z [Term] id: GO:1905021 name: regulation of threonine-tRNA ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] synonym: "regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of TRS" RELATED [GOC:TermGenie] is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004829 ! threonine-tRNA ligase activity relationship: regulates GO:0004829 ! threonine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:12:23Z [Term] id: GO:1905022 name: negative regulation of threonine-tRNA ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] synonym: "down regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of TRS" RELATED [GOC:TermGenie] synonym: "down-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of TRS" RELATED [GOC:TermGenie] synonym: "downregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of TRS" RELATED [GOC:TermGenie] synonym: "inhibition of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of threonine translase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of TRS" RELATED [GOC:TermGenie] synonym: "negative regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of TRS" RELATED [GOC:TermGenie] is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004829 ! threonine-tRNA ligase activity relationship: negatively_regulates GO:0004829 ! threonine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:12:32Z [Term] id: GO:1905023 name: positive regulation of threonine-tRNA ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] synonym: "activation of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "activation of threonine translase activity" NARROW [GOC:TermGenie] synonym: "activation of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of threonine-tRNA ligase activity" NARROW [GOC:TermGenie] synonym: "activation of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of TRS" RELATED [GOC:TermGenie] synonym: "positive regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of TRS" RELATED [GOC:TermGenie] synonym: "up regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of TRS" RELATED [GOC:TermGenie] synonym: "up-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of TRS" RELATED [GOC:TermGenie] synonym: "upregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of threonine translase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of TRS" RELATED [GOC:TermGenie] is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004829 ! threonine-tRNA ligase activity relationship: positively_regulates GO:0004829 ! threonine-tRNA ligase activity created_by: sl creation_date: 2016-03-03T19:12:41Z [Term] id: GO:1905024 name: regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "regulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential relationship: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential created_by: rph creation_date: 2016-03-04T11:19:02Z [Term] id: GO:1905025 name: negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "down regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "down regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "down-regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "downregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "downregulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "inhibition of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "negative regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "negative regulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:1903946 ! negative regulation of ventricular cardiac muscle cell action potential is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential relationship: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential created_by: rph creation_date: 2016-03-04T11:19:12Z [Term] id: GO:1905026 name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] synonym: "activation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "activation of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "activation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "positive regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "positive regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "up regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "up-regulation of ventricular repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] synonym: "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] synonym: "upregulation of ventricular repolarization" RELATED [GOC:TermGenie] is_a: GO:1903947 ! positive regulation of ventricular cardiac muscle cell action potential is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential relationship: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential created_by: rph creation_date: 2016-03-04T11:19:21Z [Term] id: GO:1905027 name: regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0098904 ! regulation of AV node cell action potential is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086045 ! membrane depolarization during AV node cell action potential relationship: regulates GO:0086045 ! membrane depolarization during AV node cell action potential created_by: rph creation_date: 2016-03-04T13:46:06Z [Term] id: GO:1905028 name: negative regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:1900826 ! negative regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1903950 ! negative regulation of AV node cell action potential is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential relationship: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential created_by: rph creation_date: 2016-03-04T13:46:15Z [Term] id: GO:1905029 name: positive regulation of membrane depolarization during AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] synonym: "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:1900827 ! positive regulation of membrane depolarization during cardiac muscle cell action potential is_a: GO:1903951 ! positive regulation of AV node cell action potential is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential relationship: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential created_by: rph creation_date: 2016-03-04T13:46:24Z [Term] id: GO:1905030 name: voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential namespace: molecular_function def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005] subset: goslim_synapse synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] is_a: GO:0005244 ! voltage-gated ion channel activity intersection_of: GO:0005244 ! voltage-gated ion channel activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0060078 ! regulation of postsynaptic membrane potential created_by: dos creation_date: 2016-03-04T15:51:54Z [Term] id: GO:1905031 name: regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] is_a: GO:0098901 ! regulation of cardiac muscle cell action potential is_a: GO:0098903 ! regulation of membrane repolarization during action potential is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential relationship: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential created_by: rph creation_date: 2016-03-07T10:24:34Z [Term] id: GO:1905032 name: negative regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] synonym: "down regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] is_a: GO:0034766 ! negative regulation of ion transmembrane transport is_a: GO:0045759 ! negative regulation of action potential is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential relationship: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential created_by: rph creation_date: 2016-03-07T10:24:44Z [Term] id: GO:1905033 name: positive regulation of membrane repolarization during cardiac muscle cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] synonym: "activation of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "up regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0034767 ! positive regulation of ion transmembrane transport is_a: GO:0045760 ! positive regulation of action potential is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential relationship: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential created_by: rph creation_date: 2016-03-07T10:24:53Z [Term] id: GO:1905034 name: regulation of antifungal innate immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:1900150 ! regulation of defense response to fungus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061760 ! antifungal innate immune response relationship: regulates GO:0061760 ! antifungal innate immune response created_by: dph creation_date: 2016-03-07T20:07:54Z [Term] id: GO:1905035 name: negative regulation of antifungal innate immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] synonym: "down regulation of antifungal innate immune response" EXACT [GOC:TermGenie] synonym: "down-regulation of antifungal innate immune response" EXACT [GOC:TermGenie] synonym: "downregulation of antifungal innate immune response" EXACT [GOC:TermGenie] synonym: "inhibition of antifungal innate immune response" NARROW [GOC:TermGenie] is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:1905034 ! regulation of antifungal innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061760 ! antifungal innate immune response relationship: negatively_regulates GO:0061760 ! antifungal innate immune response created_by: dph creation_date: 2016-03-07T20:08:05Z [Term] id: GO:1905036 name: positive regulation of antifungal innate immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] synonym: "activation of antifungal innate immune response" NARROW [GOC:TermGenie] synonym: "up regulation of antifungal innate immune response" EXACT [GOC:TermGenie] synonym: "up-regulation of antifungal innate immune response" EXACT [GOC:TermGenie] synonym: "upregulation of antifungal innate immune response" EXACT [GOC:TermGenie] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:1905034 ! regulation of antifungal innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061760 ! antifungal innate immune response relationship: positively_regulates GO:0061760 ! antifungal innate immune response created_by: dph creation_date: 2016-03-07T20:08:26Z [Term] id: GO:1905037 name: autophagosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GO_REF:000103, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] is_a: GO:0007033 ! vacuole organization relationship: part_of GO:0016236 ! macroautophagy created_by: bf creation_date: 2016-03-08T14:18:10Z [Term] id: GO:1905038 name: regulation of membrane lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280] synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006643 ! membrane lipid metabolic process relationship: regulates GO:0006643 ! membrane lipid metabolic process created_by: tb creation_date: 2016-03-08T20:41:32Z [Term] id: GO:1905039 name: carboxylic acid transmembrane transport namespace: biological_process def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1903825 ! organic acid transmembrane transport created_by: vw creation_date: 2016-03-09T15:33:53Z [Term] id: GO:1905040 name: otic placode development namespace: biological_process def: "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] synonym: "auditory placode development" RELATED [GOC:TermGenie] synonym: "ear placode development" RELATED [GOC:TermGenie] synonym: "ear/otic placode development" RELATED [GOC:TermGenie] synonym: "octaval placode development" RELATED [GOC:TermGenie] synonym: "octaval VIII placode development" RELATED [GOC:TermGenie] synonym: "placoda otica development" EXACT [GOC:TermGenie] is_a: GO:0071696 ! ectodermal placode development created_by: bf creation_date: 2016-03-10T09:30:20Z [Term] id: GO:1905041 name: regulation of epithelium regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] synonym: "regulation of regeneration of epithelium" EXACT [GOC:TermGenie] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061041 ! regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990399 ! epithelium regeneration relationship: regulates GO:1990399 ! epithelium regeneration created_by: rph creation_date: 2016-03-11T10:58:53Z [Term] id: GO:1905042 name: negative regulation of epithelium regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] synonym: "down regulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "down regulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium regeneration" NARROW [GOC:TermGenie] synonym: "inhibition of regeneration of epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of regeneration of epithelium" EXACT [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1905041 ! regulation of epithelium regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990399 ! epithelium regeneration relationship: negatively_regulates GO:1990399 ! epithelium regeneration created_by: rph creation_date: 2016-03-11T10:59:03Z [Term] id: GO:1905043 name: positive regulation of epithelium regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] synonym: "activation of epithelium regeneration" NARROW [GOC:TermGenie] synonym: "activation of regeneration of epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "up regulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of regeneration of epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of regeneration of epithelium" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1905041 ! regulation of epithelium regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990399 ! epithelium regeneration relationship: positively_regulates GO:1990399 ! epithelium regeneration created_by: rph creation_date: 2016-03-11T10:59:12Z [Term] id: GO:1905044 name: regulation of Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0048679 ! regulation of axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration relationship: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration created_by: rph creation_date: 2016-03-11T14:47:35Z [Term] id: GO:1905045 name: negative regulation of Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] synonym: "down regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie] is_a: GO:0010626 ! negative regulation of Schwann cell proliferation is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration relationship: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration created_by: rph creation_date: 2016-03-11T14:47:45Z [Term] id: GO:1905046 name: positive regulation of Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] synonym: "activation of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0010625 ! positive regulation of Schwann cell proliferation is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration relationship: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration created_by: rph creation_date: 2016-03-11T14:47:54Z [Term] id: GO:1905047 name: mitotic spindle pole body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body." [GO_REF:000103, GOC:TermGenie, PMID:24963130] is_a: GO:0051300 ! spindle pole body organization created_by: vw creation_date: 2016-03-14T09:48:42Z [Term] id: GO:1905048 name: regulation of metallopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] synonym: "regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "regulation of metalloproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008237 ! metallopeptidase activity relationship: regulates GO:0008237 ! metallopeptidase activity created_by: mm2 creation_date: 2016-03-15T16:44:27Z [Term] id: GO:1905049 name: negative regulation of metallopeptidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] synonym: "down regulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "down regulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "down-regulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "downregulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of metallopeptidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "inhibition of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "negative regulation of metalloproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:1905048 ! regulation of metallopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008237 ! metallopeptidase activity relationship: negatively_regulates GO:0008237 ! metallopeptidase activity created_by: mm2 creation_date: 2016-03-15T16:44:37Z [Term] id: GO:1905050 name: positive regulation of metallopeptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] synonym: "activation of metallopeptidase activity" NARROW [GOC:TermGenie] synonym: "activation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "activation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "positive regulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "up regulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "up-regulation of metalloproteinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of metallopeptidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of metalloprotease activity" NARROW [GOC:TermGenie] synonym: "upregulation of metalloproteinase activity" NARROW [GOC:TermGenie] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:1905048 ! regulation of metallopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008237 ! metallopeptidase activity relationship: positively_regulates GO:0008237 ! metallopeptidase activity created_by: mm2 creation_date: 2016-03-15T16:44:46Z [Term] id: GO:1905051 name: regulation of base-excision repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] synonym: "regulation of BER" EXACT [GOC:TermGenie] is_a: GO:0006282 ! regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006284 ! base-excision repair relationship: regulates GO:0006284 ! base-excision repair created_by: ah creation_date: 2016-03-16T10:52:00Z [Term] id: GO:1905052 name: negative regulation of base-excision repair namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] synonym: "down regulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "down regulation of BER" EXACT [GOC:TermGenie] synonym: "down-regulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "down-regulation of BER" EXACT [GOC:TermGenie] synonym: "downregulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "downregulation of BER" EXACT [GOC:TermGenie] synonym: "inhibition of base-excision repair" NARROW [GOC:TermGenie] synonym: "inhibition of BER" NARROW [GOC:TermGenie] synonym: "negative regulation of BER" EXACT [GOC:TermGenie] is_a: GO:0045738 ! negative regulation of DNA repair is_a: GO:1905051 ! regulation of base-excision repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006284 ! base-excision repair relationship: negatively_regulates GO:0006284 ! base-excision repair created_by: ah creation_date: 2016-03-16T10:52:09Z [Term] id: GO:1905053 name: positive regulation of base-excision repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] synonym: "activation of base-excision repair" NARROW [GOC:TermGenie] synonym: "activation of BER" NARROW [GOC:TermGenie] synonym: "positive regulation of BER" EXACT [GOC:TermGenie] synonym: "up regulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "up regulation of BER" EXACT [GOC:TermGenie] synonym: "up-regulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "up-regulation of BER" EXACT [GOC:TermGenie] synonym: "upregulation of base-excision repair" EXACT [GOC:TermGenie] synonym: "upregulation of BER" EXACT [GOC:TermGenie] is_a: GO:0045739 ! positive regulation of DNA repair is_a: GO:1905051 ! regulation of base-excision repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006284 ! base-excision repair relationship: positively_regulates GO:0006284 ! base-excision repair created_by: ah creation_date: 2016-03-16T10:52:18Z [Term] id: GO:1905054 name: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:15919193, PMID:23918386] subset: goslim_synapse synonym: "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0048763 ! calcium-induced calcium release activity intersection_of: GO:0048763 ! calcium-induced calcium release activity intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-17T12:12:53Z [Term] id: GO:1905055 name: calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722] subset: goslim_synapse synonym: "calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0015368 ! calcium:cation antiporter activity intersection_of: GO:0015368 ! calcium:cation antiporter activity intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-17T14:35:35Z [Term] id: GO:1905056 name: calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium-transporting ATPase activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962] subset: goslim_synapse synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] is_a: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration relationship: part_of GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-17T14:35:25Z [Term] id: GO:1905057 name: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels namespace: molecular_function def: "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20734177] subset: goslim_synapse synonym: "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels intersection_of: GO:0005245 ! voltage-gated calcium channel activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-18T12:31:48Z [Term] id: GO:1905058 name: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:23639769] subset: goslim_synapse synonym: "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] is_a: GO:0048763 ! calcium-induced calcium release activity intersection_of: GO:0048763 ! calcium-induced calcium release activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-18T12:31:59Z [Term] id: GO:1905059 name: calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20678993] subset: goslim_synapse synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] synonym: "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] synonym: "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] is_a: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: GO:0005388 ! calcium transmembrane transporter activity, phosphorylative mechanism intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-18T12:32:08Z [Term] id: GO:1905060 name: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration namespace: molecular_function def: "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:18024055] subset: goslim_synapse synonym: "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels" EXACT syngo_official_label [] is_a: GO:0015368 ! calcium:cation antiporter activity intersection_of: GO:0015368 ! calcium:cation antiporter activity intersection_of: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration relationship: part_of GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration created_by: dos creation_date: 2016-03-18T12:32:17Z [Term] id: GO:1905061 name: negative regulation of cardioblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097] synonym: "down regulation of cardioblast proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardioblast proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of cardioblast proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of cardioblast proliferation" NARROW [GOC:TermGenie] is_a: GO:0003264 ! regulation of cardioblast proliferation is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003263 ! cardioblast proliferation relationship: negatively_regulates GO:0003263 ! cardioblast proliferation created_by: bc creation_date: 2016-03-21T11:00:13Z [Term] id: GO:1905062 name: positive regulation of cardioblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097] synonym: "activation of cardioblast proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of cardioblast proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardioblast proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of cardioblast proliferation" EXACT [GOC:TermGenie] is_a: GO:0003264 ! regulation of cardioblast proliferation is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003263 ! cardioblast proliferation relationship: positively_regulates GO:0003263 ! cardioblast proliferation created_by: bc creation_date: 2016-03-21T11:00:23Z [Term] id: GO:1905063 name: regulation of vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035886 ! vascular smooth muscle cell differentiation relationship: regulates GO:0035886 ! vascular smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:14:53Z [Term] id: GO:1905064 name: negative regulation of vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:1901343 ! negative regulation of vasculature development is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation relationship: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:03Z [Term] id: GO:1905065 name: positive regulation of vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:1904018 ! positive regulation of vasculature development is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation relationship: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:13Z [Term] id: GO:1905066 name: regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:46:56Z [Term] id: GO:1905067 name: negative regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "down regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:47:06Z [Term] id: GO:1905068 name: positive regulation of canonical Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] synonym: "activation of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development created_by: bc creation_date: 2016-03-21T12:47:15Z [Term] id: GO:1905069 name: allantois development namespace: biological_process def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579] synonym: "allantoic bud development" RELATED [GOC:TermGenie] is_a: GO:1903867 ! extraembryonic membrane development created_by: cls creation_date: 2016-03-21T15:18:21Z [Term] id: GO:1905070 name: anterior visceral endoderm cell migration namespace: biological_process def: "The orderly movement of an anterior visceral endoderm cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:17078044] is_a: GO:0016477 ! cell migration created_by: cls creation_date: 2016-03-21T15:18:32Z [Term] id: GO:1905071 name: tight junction disassembly namespace: biological_process def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "occluding junction disassembly" EXACT [] is_a: GO:0120193 ! tight junction organization is_a: GO:0150147 ! cell-cell junction disassembly created_by: rl creation_date: 2016-03-23T12:35:08Z [Term] id: GO:1905072 name: cardiac jelly development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439] synonym: "heart cardiac jelly development" EXACT [GOC:TermGenie] is_a: GO:0009888 ! tissue development created_by: rl creation_date: 2016-03-23T13:17:59Z [Term] id: GO:1905073 name: regulation of tight junction disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905071 ! tight junction disassembly relationship: regulates GO:1905071 ! tight junction disassembly created_by: rl creation_date: 2016-03-23T19:32:51Z [Term] id: GO:1905074 name: negative regulation of tight junction disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "negative regulation of tight junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905071 ! tight junction disassembly relationship: negatively_regulates GO:1905071 ! tight junction disassembly created_by: rl creation_date: 2016-03-23T19:33:01Z [Term] id: GO:1905075 name: positive regulation of tight junction disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905071 ! tight junction disassembly relationship: positively_regulates GO:1905071 ! tight junction disassembly created_by: rl creation_date: 2016-03-23T19:33:10Z [Term] id: GO:1905076 name: regulation of interleukin-17 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). synonym: "regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "regulation of IL17A secretion" EXACT [GOC:TermGenie] is_a: GO:0032660 ! regulation of interleukin-17 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072615 ! interleukin-17 secretion relationship: regulates GO:0072615 ! interleukin-17 secretion created_by: bhm creation_date: 2016-03-24T15:44:21Z [Term] id: GO:1905077 name: negative regulation of interleukin-17 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). synonym: "down regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "down regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "down regulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "down regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "downregulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "downregulation of interleukin-17 secretion" EXACT [GOC:TermGenie] synonym: "inhibition of CTLA-8 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of IL-17 secretion" NARROW [GOC:TermGenie] synonym: "inhibition of IL-17A secretion" NARROW [GOC:TermGenie] synonym: "inhibition of IL17A secretion" NARROW [GOC:TermGenie] synonym: "inhibition of interleukin-17 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IL17A secretion" EXACT [GOC:TermGenie] is_a: GO:0032700 ! negative regulation of interleukin-17 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:1905076 ! regulation of interleukin-17 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072615 ! interleukin-17 secretion relationship: negatively_regulates GO:0072615 ! interleukin-17 secretion created_by: bhm creation_date: 2016-03-24T15:44:31Z [Term] id: GO:1905078 name: positive regulation of interleukin-17 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). synonym: "activation of CTLA-8 secretion" NARROW [GOC:TermGenie] synonym: "activation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie] synonym: "activation of IL-17 secretion" NARROW [GOC:TermGenie] synonym: "activation of IL-17A secretion" NARROW [GOC:TermGenie] synonym: "activation of IL17A secretion" NARROW [GOC:TermGenie] synonym: "activation of interleukin-17 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "up regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "up regulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "up regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of CTLA-8 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IL-17 secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IL-17A secretion" EXACT [GOC:TermGenie] synonym: "upregulation of IL17A secretion" EXACT [GOC:TermGenie] synonym: "upregulation of interleukin-17 secretion" EXACT [GOC:TermGenie] is_a: GO:0032740 ! positive regulation of interleukin-17 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:1905076 ! regulation of interleukin-17 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072615 ! interleukin-17 secretion relationship: positively_regulates GO:0072615 ! interleukin-17 secretion created_by: bhm creation_date: 2016-03-24T15:44:40Z [Term] id: GO:1905079 name: regulation of cerebellar neuron development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098749 ! cerebellar neuron development relationship: regulates GO:0098749 ! cerebellar neuron development created_by: hjd creation_date: 2016-03-24T19:45:17Z [Term] id: GO:1905080 name: negative regulation of cerebellar neuron development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098749 ! cerebellar neuron development relationship: negatively_regulates GO:0098749 ! cerebellar neuron development created_by: hjd creation_date: 2016-03-24T19:45:26Z [Term] id: GO:1905081 name: positive regulation of cerebellar neuron development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie] synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098749 ! cerebellar neuron development relationship: positively_regulates GO:0098749 ! cerebellar neuron development created_by: hjd creation_date: 2016-03-24T19:45:35Z [Term] id: GO:1905082 name: regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070125 ! mitochondrial translational elongation relationship: regulates GO:0070125 ! mitochondrial translational elongation created_by: hjd creation_date: 2016-03-25T17:37:03Z [Term] id: GO:1905083 name: negative regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:0070130 ! negative regulation of mitochondrial translation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070125 ! mitochondrial translational elongation relationship: negatively_regulates GO:0070125 ! mitochondrial translational elongation created_by: hjd creation_date: 2016-03-25T17:37:13Z [Term] id: GO:1905084 name: positive regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:0070131 ! positive regulation of mitochondrial translation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070125 ! mitochondrial translational elongation relationship: positively_regulates GO:0070125 ! mitochondrial translational elongation created_by: hjd creation_date: 2016-03-25T17:37:22Z [Term] id: GO:1905085 name: regulation of bioluminescence namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008218 ! bioluminescence relationship: regulates GO:0008218 ! bioluminescence created_by: rph creation_date: 2016-03-29T07:51:07Z [Term] id: GO:1905086 name: negative regulation of bioluminescence namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] synonym: "down regulation of bioluminescence" EXACT [GOC:TermGenie] synonym: "down-regulation of bioluminescence" EXACT [GOC:TermGenie] synonym: "downregulation of bioluminescence" EXACT [GOC:TermGenie] synonym: "inhibition of bioluminescence" NARROW [GOC:TermGenie] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:1905085 ! regulation of bioluminescence intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008218 ! bioluminescence relationship: negatively_regulates GO:0008218 ! bioluminescence created_by: rph creation_date: 2016-03-29T07:51:17Z [Term] id: GO:1905087 name: positive regulation of bioluminescence namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] synonym: "activation of bioluminescence" NARROW [GOC:TermGenie] synonym: "up regulation of bioluminescence" EXACT [GOC:TermGenie] synonym: "up-regulation of bioluminescence" EXACT [GOC:TermGenie] synonym: "upregulation of bioluminescence" EXACT [GOC:TermGenie] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1905085 ! regulation of bioluminescence intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008218 ! bioluminescence relationship: positively_regulates GO:0008218 ! bioluminescence created_by: rph creation_date: 2016-03-29T07:51:27Z [Term] id: GO:1905088 name: positive regulation of synaptonemal complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24797370] synonym: "activation of synaptonemal complex assembly" NARROW [GOC:TermGenie] synonym: "activation of synaptonemal complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of synaptonemal complex formation" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:0060903 ! positive regulation of meiosis I is_a: GO:0090173 ! regulation of synaptonemal complex assembly is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007130 ! synaptonemal complex assembly relationship: positively_regulates GO:0007130 ! synaptonemal complex assembly created_by: mec creation_date: 2016-03-30T08:39:03Z [Term] id: GO:1905089 name: regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] synonym: "regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] synonym: "regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1901524 ! regulation of mitophagy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization relationship: regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization created_by: pad creation_date: 2016-03-30T15:34:29Z [Term] id: GO:1905090 name: negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] synonym: "down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] synonym: "negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] synonym: "negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905089 ! regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization relationship: negatively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization created_by: pad creation_date: 2016-03-30T15:34:38Z [Term] id: GO:1905091 name: positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] synonym: "activation of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] synonym: "positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] synonym: "positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] synonym: "up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901526 ! positive regulation of mitophagy is_a: GO:1905089 ! regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization relationship: positively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization created_by: pad creation_date: 2016-03-30T15:34:47Z [Term] id: GO:1905092 name: response to diosgenin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] is_a: GO:0036314 ! response to sterol is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1905836 ! response to triterpenoid created_by: bc creation_date: 2016-03-31T11:04:28Z [Term] id: GO:1905093 name: cellular response to diosgenin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] is_a: GO:0035690 ! cellular response to drug is_a: GO:0036315 ! cellular response to sterol is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1905092 ! response to diosgenin is_a: GO:1905837 ! cellular response to triterpenoid created_by: bc creation_date: 2016-03-31T11:04:38Z [Term] id: GO:1905094 name: regulation of apolipoprotein A-I-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] synonym: "regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway relationship: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway created_by: bc creation_date: 2016-03-31T11:33:48Z [Term] id: GO:1905095 name: negative regulation of apolipoprotein A-I-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] synonym: "down regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway relationship: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway created_by: bc creation_date: 2016-03-31T11:33:58Z [Term] id: GO:1905096 name: positive regulation of apolipoprotein A-I-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] synonym: "activation of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway relationship: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway created_by: bc creation_date: 2016-03-31T11:34:07Z [Term] id: GO:1905097 name: regulation of guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] synonym: "regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "regulation of GDS" EXACT [GOC:TermGenie] synonym: "regulation of GEF" EXACT [GOC:TermGenie] synonym: "regulation of GNRP" NARROW [GOC:TermGenie] synonym: "regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0050789 ! regulation of biological process is_a: GO:1904424 ! regulation of GTP binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005085 ! guanyl-nucleotide exchange factor activity relationship: regulates GO:0005085 ! guanyl-nucleotide exchange factor activity created_by: sl creation_date: 2016-03-31T16:09:35Z [Term] id: GO:1905098 name: negative regulation of guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] synonym: "down regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "down regulation of GDS" EXACT [GOC:TermGenie] synonym: "down regulation of GEF" EXACT [GOC:TermGenie] synonym: "down regulation of GNRP" NARROW [GOC:TermGenie] synonym: "down regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "down regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "down regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "down-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "down-regulation of GDS" EXACT [GOC:TermGenie] synonym: "down-regulation of GEF" EXACT [GOC:TermGenie] synonym: "down-regulation of GNRP" NARROW [GOC:TermGenie] synonym: "down-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "downregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "downregulation of GDS" EXACT [GOC:TermGenie] synonym: "downregulation of GEF" EXACT [GOC:TermGenie] synonym: "downregulation of GNRP" NARROW [GOC:TermGenie] synonym: "downregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "downregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "downregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "inhibition of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie] synonym: "inhibition of GDS" NARROW [GOC:TermGenie] synonym: "inhibition of GEF" NARROW [GOC:TermGenie] synonym: "inhibition of GNRP" NARROW [GOC:TermGenie] synonym: "inhibition of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie] synonym: "inhibition of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie] synonym: "inhibition of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie] synonym: "negative regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "negative regulation of GDS" EXACT [GOC:TermGenie] synonym: "negative regulation of GEF" EXACT [GOC:TermGenie] synonym: "negative regulation of GNRP" NARROW [GOC:TermGenie] synonym: "negative regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "negative regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051099 ! positive regulation of binding is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity relationship: negatively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity created_by: sl creation_date: 2016-03-31T16:09:45Z [Term] id: GO:1905099 name: positive regulation of guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] synonym: "activation of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie] synonym: "activation of GDS" NARROW [GOC:TermGenie] synonym: "activation of GEF" NARROW [GOC:TermGenie] synonym: "activation of GNRP" NARROW [GOC:TermGenie] synonym: "activation of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie] synonym: "activation of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie] synonym: "activation of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie] synonym: "positive regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "positive regulation of GDS" EXACT [GOC:TermGenie] synonym: "positive regulation of GEF" EXACT [GOC:TermGenie] synonym: "positive regulation of GNRP" NARROW [GOC:TermGenie] synonym: "positive regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "positive regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "up regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "up regulation of GDS" EXACT [GOC:TermGenie] synonym: "up regulation of GEF" EXACT [GOC:TermGenie] synonym: "up regulation of GNRP" NARROW [GOC:TermGenie] synonym: "up regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "up regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "up regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "up-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "up-regulation of GDS" EXACT [GOC:TermGenie] synonym: "up-regulation of GEF" EXACT [GOC:TermGenie] synonym: "up-regulation of GNRP" NARROW [GOC:TermGenie] synonym: "up-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] synonym: "upregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] synonym: "upregulation of GDS" EXACT [GOC:TermGenie] synonym: "upregulation of GEF" EXACT [GOC:TermGenie] synonym: "upregulation of GNRP" NARROW [GOC:TermGenie] synonym: "upregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] synonym: "upregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] synonym: "upregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1904426 ! positive regulation of GTP binding is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity relationship: positively_regulates GO:0005085 ! guanyl-nucleotide exchange factor activity created_by: sl creation_date: 2016-03-31T16:09:54Z [Term] id: GO:1905100 name: regulation of apoptosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] synonym: "regulation of apoptosome formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097314 ! apoptosome assembly relationship: regulates GO:0097314 ! apoptosome assembly created_by: bc creation_date: 2016-04-04T08:57:42Z [Term] id: GO:1905101 name: negative regulation of apoptosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] synonym: "down regulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "down regulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosome assembly" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosome formation" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosome formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905100 ! regulation of apoptosome assembly is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097314 ! apoptosome assembly relationship: negatively_regulates GO:0097314 ! apoptosome assembly created_by: bc creation_date: 2016-04-04T08:57:51Z [Term] id: GO:1905102 name: positive regulation of apoptosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] synonym: "activation of apoptosome assembly" NARROW [GOC:TermGenie] synonym: "activation of apoptosome formation" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "up regulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "up regulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosome formation" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosome formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905100 ! regulation of apoptosome assembly is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097314 ! apoptosome assembly relationship: positively_regulates GO:0097314 ! apoptosome assembly created_by: bc creation_date: 2016-04-04T08:57:59Z [Term] id: GO:1905103 name: integral component of lysosomal membrane namespace: cellular_component def: "The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396] synonym: "integral component of lysosome membrane" EXACT [GOC:bf] synonym: "integral to lysosomal membrane" NARROW [] is_a: GO:0031166 ! integral component of vacuolar membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005765 ! lysosomal membrane relationship: part_of GO:0005765 ! lysosomal membrane created_by: bf creation_date: 2016-04-04T10:29:16Z [Term] id: GO:1905104 name: obsolete response to ouabain namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2016-04-04T19:08:07Z [Term] id: GO:1905105 name: obsolete cellular response to ouabain namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2016-04-04T19:08:16Z [Term] id: GO:1905106 name: obsolete response to Dizocilpine namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2016-04-04T20:26:52Z [Term] id: GO:1905107 name: obsolete cellular response to Dizocilpine namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2016-04-04T20:27:01Z [Term] id: GO:1905108 name: guanosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanosine." [GO_REF:0000067, GOC:TermGenie, PMID:26007660] is_a: GO:0032550 ! purine ribonucleoside binding created_by: al creation_date: 2016-04-05T08:30:47Z [Term] id: GO:1905109 name: regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0101010 ! pulmonary blood vessel remodeling relationship: regulates GO:0101010 ! pulmonary blood vessel remodeling created_by: bc creation_date: 2016-04-06T13:07:24Z [Term] id: GO:1905110 name: negative regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] is_a: GO:0060313 ! negative regulation of blood vessel remodeling is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling relationship: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling created_by: bc creation_date: 2016-04-06T13:07:33Z [Term] id: GO:1905111 name: positive regulation of pulmonary blood vessel remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling is_a: GO:2000504 ! positive regulation of blood vessel remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling relationship: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling created_by: bc creation_date: 2016-04-06T13:07:42Z [Term] id: GO:1905112 name: regulation of centromere clustering at the mitotic nuclear envelope namespace: biological_process def: "Any process that modulates the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] synonym: "regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] synonym: "regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "regulation of rabl configuration" RELATED [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072766 ! centromere clustering at the mitotic nuclear envelope relationship: regulates GO:0072766 ! centromere clustering at the mitotic nuclear envelope created_by: al creation_date: 2016-04-06T16:25:41Z [Term] id: GO:1905113 name: positive regulation of centromere clustering at the mitotic nuclear envelope namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] synonym: "activation of centromere clustering at the nuclear envelope" NARROW [GOC:TermGenie] synonym: "activation of centromere clustering at the nuclear periphery" NARROW [GOC:TermGenie] synonym: "activation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "activation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "activation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "activation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "activation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "activation of rabl configuration" RELATED [GOC:TermGenie] synonym: "positive regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] synonym: "positive regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "positive regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "positive regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "positive regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "positive regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "positive regulation of rabl configuration" RELATED [GOC:TermGenie] synonym: "up regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] synonym: "up regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] synonym: "up regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "up regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "up regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "up regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "up regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "up regulation of rabl configuration" RELATED [GOC:TermGenie] synonym: "up-regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] synonym: "up-regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "up-regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "up-regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "up-regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "up-regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "up-regulation of rabl configuration" RELATED [GOC:TermGenie] synonym: "upregulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] synonym: "upregulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] synonym: "upregulation of centromere-SPB clustering" RELATED [GOC:TermGenie] synonym: "upregulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] synonym: "upregulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] synonym: "upregulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] synonym: "upregulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] synonym: "upregulation of rabl configuration" RELATED [GOC:TermGenie] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905112 ! regulation of centromere clustering at the mitotic nuclear envelope intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072766 ! centromere clustering at the mitotic nuclear envelope relationship: positively_regulates GO:0072766 ! centromere clustering at the mitotic nuclear envelope created_by: al creation_date: 2016-04-06T16:25:49Z [Term] id: GO:1905114 name: cell surface receptor signaling pathway involved in cell-cell signaling namespace: biological_process def: "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0] synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: part_of GO:0007267 ! cell-cell signaling relationship: part_of GO:0007267 ! cell-cell signaling created_by: dos creation_date: 2016-04-06T16:59:57Z [Term] id: GO:1905115 name: regulation of lateral attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore relationship: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore created_by: al creation_date: 2016-04-07T14:25:25Z [Term] id: GO:1905116 name: positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] synonym: "activation of lateral attachment of mitotic spindle microtubules to kinetochore" NARROW [GOC:TermGenie] synonym: "up regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] synonym: "up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] synonym: "upregulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore is_a: GO:1905115 ! regulation of lateral attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore relationship: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore created_by: al creation_date: 2016-04-07T14:25:34Z [Term] id: GO:1905117 name: regulation of ribonucleoside-diphosphate reductase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891] comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype). synonym: "regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "regulation of ribonucleotide diphosphate reductase activity" EXACT [GOC:TermGenie] synonym: "regulation of ribonucleotide reductase activity" BROAD [GOC:TermGenie] synonym: "regulation of RNR" RELATED [GOC:TermGenie] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity relationship: regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity created_by: bhm creation_date: 2016-04-08T08:06:17Z [Term] id: GO:1905118 name: positive regulation of ribonucleoside-diphosphate reductase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891] comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype). synonym: "activation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "activation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "activation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "activation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "activation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "activation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "activation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "activation of RNR" RELATED [GOC:TermGenie] synonym: "positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "positive regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of RNR" RELATED [GOC:TermGenie] synonym: "up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "up regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up regulation of RNR" RELATED [GOC:TermGenie] synonym: "up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "up-regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of RNR" RELATED [GOC:TermGenie] synonym: "upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] synonym: "upregulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] synonym: "upregulation of RNR" RELATED [GOC:TermGenie] is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:1905117 ! regulation of ribonucleoside-diphosphate reductase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity relationship: positively_regulates GO:0061731 ! ribonucleoside-diphosphate reductase activity created_by: bhm creation_date: 2016-04-08T08:06:35Z [Term] id: GO:1905119 name: response to haloperidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2016-04-08T12:36:39Z [Term] id: GO:1905120 name: cellular response to haloperidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone is_a: GO:1905119 ! response to haloperidol created_by: dw creation_date: 2016-04-08T12:36:47Z [Term] id: GO:1905121 name: microtubule sliding involved in mitotic spindle elongation namespace: biological_process def: "Any microtubule sliding that is involved in mitotic spindle elongation." [GO_REF:0000060, GOC:TermGenie, GOC:vw, PMID:19686686] synonym: "microtubule sliding involved in spindle elongation during mitosis" EXACT [GOC:TermGenie] synonym: "microtubule translocation involved in mitotic spindle elongation" EXACT [GOC:TermGenie] synonym: "microtubule translocation involved in spindle elongation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0051012 ! microtubule sliding is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051012 ! microtubule sliding intersection_of: part_of GO:0000022 ! mitotic spindle elongation relationship: part_of GO:0000022 ! mitotic spindle elongation created_by: pr creation_date: 2016-04-08T15:06:14Z [Term] id: GO:1905123 name: regulation of glucosylceramidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] synonym: "regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of GCase activity" EXACT [PMID:24334770] synonym: "regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004348 ! glucosylceramidase activity relationship: regulates GO:0004348 ! glucosylceramidase activity created_by: bf creation_date: 2016-04-11T15:44:26Z [Term] id: GO:1905124 name: negative regulation of glucosylceramidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "inhibition of acid beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of beta-glucosylceramidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ceramide glucosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucosylceramidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucosylcerebrosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of psychosine hydrolase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of GCase activity" EXACT [PMID:24334770] synonym: "negative regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:1905123 ! regulation of glucosylceramidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004348 ! glucosylceramidase activity relationship: negatively_regulates GO:0004348 ! glucosylceramidase activity created_by: bf creation_date: 2016-04-11T15:44:35Z [Term] id: GO:1905125 name: positive regulation of glucosylceramidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of acid beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "activation of beta-glucosylceramidase activity" NARROW [GOC:TermGenie] synonym: "activation of ceramide glucosidase activity" NARROW [GOC:TermGenie] synonym: "activation of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "activation of glucocerebrosidase activity" NARROW [GOC:TermGenie] synonym: "activation of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of glucosylceramidase activity" NARROW [GOC:TermGenie] synonym: "activation of glucosylcerebrosidase activity" NARROW [GOC:TermGenie] synonym: "activation of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie] synonym: "activation of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie] synonym: "activation of psychosine hydrolase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of GCase activity" EXACT [PMID:24334770] synonym: "positive regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucosylceramidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1905123 ! regulation of glucosylceramidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004348 ! glucosylceramidase activity relationship: positively_regulates GO:0004348 ! glucosylceramidase activity created_by: bf creation_date: 2016-04-11T15:44:43Z [Term] id: GO:1905126 name: regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099640 ! axo-dendritic protein transport relationship: regulates GO:0099640 ! axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:31Z [Term] id: GO:1905127 name: negative regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie] synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0099640 ! axo-dendritic protein transport relationship: negatively_regulates GO:0099640 ! axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:40Z [Term] id: GO:1905128 name: positive regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099640 ! axo-dendritic protein transport relationship: positively_regulates GO:0099640 ! axo-dendritic protein transport created_by: sl creation_date: 2016-04-11T20:38:48Z [Term] id: GO:1905129 name: endocannabinoid signaling pathway involved in trans-synaptic signaling namespace: biological_process def: "Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807] synonym: "endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie] is_a: GO:0071926 ! endocannabinoid signaling pathway intersection_of: GO:0071926 ! endocannabinoid signaling pathway intersection_of: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid relationship: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid created_by: dos creation_date: 2016-04-12T10:45:13Z [Term] id: GO:1905130 name: carcinine import across plasma membrane namespace: biological_process def: "The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872] is_a: GO:0042886 ! amide transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:0098739 ! import across plasma membrane created_by: dph creation_date: 2016-04-12T15:15:18Z [Term] id: GO:1905131 name: carcinine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carcinine from one side of a membrane to the other." [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity created_by: dph creation_date: 2016-04-12T15:18:25Z [Term] id: GO:1905132 name: regulation of meiotic chromosome separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] synonym: "regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:1905818 ! regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051307 ! meiotic chromosome separation relationship: regulates GO:0051307 ! meiotic chromosome separation created_by: dph creation_date: 2016-04-12T17:46:29Z [Term] id: GO:1905133 name: negative regulation of meiotic chromosome separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] synonym: "down regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "down regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "down regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic chromosome separation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome separation during meiosis" NARROW [GOC:TermGenie] synonym: "inhibition of meiotic chromosome resolution" NARROW [GOC:TermGenie] synonym: "inhibition of meiotic chromosome separation" NARROW [GOC:TermGenie] synonym: "negative regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "negative regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] is_a: GO:0045835 ! negative regulation of meiotic nuclear division is_a: GO:1905132 ! regulation of meiotic chromosome separation is_a: GO:1905819 ! negative regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051307 ! meiotic chromosome separation relationship: negatively_regulates GO:0051307 ! meiotic chromosome separation created_by: dph creation_date: 2016-04-12T17:46:37Z [Term] id: GO:1905134 name: positive regulation of meiotic chromosome separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] synonym: "activation of chromosome separation during meiosis" NARROW [GOC:TermGenie] synonym: "activation of meiotic chromosome resolution" NARROW [GOC:TermGenie] synonym: "activation of meiotic chromosome separation" NARROW [GOC:TermGenie] synonym: "positive regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "positive regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "up regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "up regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic chromosome separation" EXACT [GOC:TermGenie] is_a: GO:0045836 ! positive regulation of meiotic nuclear division is_a: GO:1905132 ! regulation of meiotic chromosome separation is_a: GO:1905820 ! positive regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051307 ! meiotic chromosome separation relationship: positively_regulates GO:0051307 ! meiotic chromosome separation created_by: dph creation_date: 2016-04-12T17:46:45Z [Term] id: GO:1905135 name: biotin import across plasma membrane namespace: biological_process alt_id: GO:0044756 alt_id: GO:1901689 def: "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275] synonym: "biotin import" RELATED [] synonym: "biotin import into cell" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015878 ! biotin transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0098739 ! import across plasma membrane is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: jl creation_date: 2012-12-05T16:30:20Z [Term] id: GO:1905136 name: dethiobiotin import across plasma membrane namespace: biological_process alt_id: GO:0044757 alt_id: GO:1901690 def: "The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275] synonym: "dethiobiotin import" RELATED [] synonym: "dethiobiotin import into cell" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport is_a: GO:0098739 ! import across plasma membrane is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: jl creation_date: 2012-12-06T13:06:28Z [Term] id: GO:1905137 name: regulation of viral DNA genome packaging via site-specific sequence recognition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378] is_a: GO:1903900 ! regulation of viral life cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition relationship: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition created_by: pr creation_date: 2016-04-13T11:37:13Z [Term] id: GO:1905138 name: positive regulation of viral DNA genome packaging via site-specific sequence recognition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378] synonym: "activation of viral DNA genome packaging via site-specific sequence recognition" NARROW [GOC:TermGenie] synonym: "up regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] synonym: "up-regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] synonym: "upregulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] is_a: GO:1903902 ! positive regulation of viral life cycle is_a: GO:1905137 ! regulation of viral DNA genome packaging via site-specific sequence recognition intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition relationship: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition created_by: pr creation_date: 2016-04-13T11:37:22Z [Term] id: GO:1905139 name: apical ectodermal ridge formation namespace: biological_process def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] synonym: "AER formation" RELATED [GOC:TermGenie] synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0035107 ! appendage morphogenesis created_by: dph creation_date: 2016-04-13T11:46:40Z [Term] id: GO:1905140 name: regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "regulation of AER formation" RELATED [GOC:TermGenie] synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905139 ! apical ectodermal ridge formation relationship: regulates GO:1905139 ! apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:40Z [Term] id: GO:1905141 name: negative regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905139 ! apical ectodermal ridge formation relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:48Z [Term] id: GO:1905142 name: positive regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "activation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905139 ! apical ectodermal ridge formation relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation created_by: dph creation_date: 2016-04-13T12:16:57Z [Term] id: GO:1905143 name: eukaryotic translation initiation factor 2 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex." [GO_REF:0000079, GOC:TermGenie, PMID:23775072] synonym: "eIF-2 assembly" EXACT [GOC:TermGenie] synonym: "eIF-2 formation" EXACT [GOC:TermGenie] synonym: "eIF2 assembly" EXACT [GOC:TermGenie] synonym: "eIF2 formation" EXACT [GOC:TermGenie] synonym: "eukaryotic translation initiation factor 2 complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: dph creation_date: 2016-04-14T00:25:51Z [Term] id: GO:1905144 name: response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:0009725 ! response to hormone is_a: GO:0042493 ! response to drug is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901700 ! response to oxygen-containing compound created_by: dos creation_date: 2016-04-14T08:54:49Z [Term] id: GO:1905145 name: cellular response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035690 ! cellular response to drug is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905144 ! response to acetylcholine created_by: dos creation_date: 2016-04-14T08:54:58Z [Term] id: GO:1905146 name: lysosomal protein catabolic process namespace: biological_process def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein catabolic process in lysosome" EXACT [] synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "lysosomal protein catabolism" EXACT [GOC:bf] synonym: "lysosomal protein degradation" EXACT [GOC:bf] synonym: "lysosomal proteolysis" RELATED [PMID:24334770] synonym: "proteolysis within lysosome" RELATED [GOC:bf] is_a: GO:0007039 ! protein catabolic process in the vacuole intersection_of: GO:0044257 ! cellular protein catabolic process intersection_of: occurs_in GO:0005764 ! lysosome relationship: occurs_in GO:0005764 ! lysosome created_by: bf creation_date: 2016-04-14T12:50:34Z [Term] id: GO:1905147 name: regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014895 ! smooth muscle hypertrophy relationship: regulates GO:0014895 ! smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:07Z [Term] id: GO:1905148 name: negative regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014895 ! smooth muscle hypertrophy relationship: negatively_regulates GO:0014895 ! smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:16Z [Term] id: GO:1905149 name: positive regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014895 ! smooth muscle hypertrophy relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:24Z [Term] id: GO:1905150 name: regulation of voltage-gated sodium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] synonym: "regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005248 ! voltage-gated sodium channel activity relationship: regulates GO:0005248 ! voltage-gated sodium channel activity created_by: sl creation_date: 2016-04-15T21:47:40Z [Term] id: GO:1905151 name: negative regulation of voltage-gated sodium channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] synonym: "down regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "down regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "down-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "downregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "downregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "inhibition of voltage gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie] synonym: "inhibition of voltage-sensitive sodium channel" NARROW [GOC:TermGenie] synonym: "negative regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "negative regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005248 ! voltage-gated sodium channel activity relationship: negatively_regulates GO:0005248 ! voltage-gated sodium channel activity created_by: sl creation_date: 2016-04-15T21:47:49Z [Term] id: GO:1905152 name: positive regulation of voltage-gated sodium channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] synonym: "activation of voltage gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated sodium channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie] synonym: "activation of voltage-sensitive sodium channel" NARROW [GOC:TermGenie] synonym: "positive regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "positive regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "up regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "up regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "up-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] synonym: "upregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] synonym: "upregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005248 ! voltage-gated sodium channel activity relationship: positively_regulates GO:0005248 ! voltage-gated sodium channel activity created_by: sl creation_date: 2016-04-15T21:47:57Z [Term] id: GO:1905153 name: regulation of membrane invagination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010324 ! membrane invagination relationship: regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:43:54Z [Term] id: GO:1905154 name: negative regulation of membrane invagination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010324 ! membrane invagination relationship: negatively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:04Z [Term] id: GO:1905155 name: positive regulation of membrane invagination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010324 ! membrane invagination relationship: positively_regulates GO:0010324 ! membrane invagination created_by: bf creation_date: 2016-04-18T15:44:12Z [Term] id: GO:1905156 name: negative regulation of photosynthesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] synonym: "down regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of photosynthesis" NARROW [GOC:TermGenie] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0031324 ! negative regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015979 ! photosynthesis relationship: negatively_regulates GO:0015979 ! photosynthesis created_by: tb creation_date: 2016-04-19T16:12:29Z [Term] id: GO:1905157 name: positive regulation of photosynthesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] synonym: "activation of photosynthesis" NARROW [GOC:TermGenie] synonym: "up regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of photosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of photosynthesis" EXACT [GOC:TermGenie] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0031325 ! positive regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015979 ! photosynthesis relationship: positively_regulates GO:0015979 ! photosynthesis created_by: tb creation_date: 2016-04-19T16:12:39Z [Term] id: GO:1905158 name: obsolete regulation of Factor XII activation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] comment: This term was accidentally approved after TermGenie review. It should not have been approved. synonym: "regulation of Hageman factor activation" EXACT [GOC:TermGenie] is_obsolete: true created_by: sl creation_date: 2016-04-19T23:03:25Z [Term] id: GO:1905159 name: obsolete negative regulation of Factor XII activation namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] comment: This term was accidentally approved after TermGenie review. It should not have been approved. synonym: "down regulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "down regulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "down-regulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "down-regulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "downregulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "downregulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "inhibition of Factor XII activation" NARROW [GOC:TermGenie] synonym: "inhibition of Hageman factor activation" NARROW [GOC:TermGenie] synonym: "negative regulation of Hageman factor activation" EXACT [GOC:TermGenie] is_obsolete: true created_by: sl creation_date: 2016-04-19T23:03:34Z [Term] id: GO:1905160 name: obsolete positive regulation of Factor XII activation namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] comment: This term was accidentally approved after TermGenie review. It should not have been approved. synonym: "activation of Factor XII activation" NARROW [GOC:TermGenie] synonym: "activation of Hageman factor activation" NARROW [GOC:TermGenie] synonym: "positive regulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "up regulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "up regulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "up-regulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "up-regulation of Hageman factor activation" EXACT [GOC:TermGenie] synonym: "upregulation of Factor XII activation" EXACT [GOC:TermGenie] synonym: "upregulation of Hageman factor activation" EXACT [GOC:TermGenie] is_obsolete: true created_by: sl creation_date: 2016-04-19T23:03:43Z [Term] id: GO:1905161 name: protein localization to phagocytic vesicle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671] synonym: "protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "protein localisation to phagosome" EXACT [PMID:23303671] synonym: "protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "protein recruitment to phagosome" EXACT [PMID:23303671] is_a: GO:0033365 ! protein localization to organelle created_by: bf creation_date: 2016-04-25T15:05:13Z [Term] id: GO:1905162 name: regulation of phagosome maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090382 ! phagosome maturation relationship: regulates GO:0090382 ! phagosome maturation created_by: bf creation_date: 2016-04-25T16:28:03Z [Term] id: GO:1905163 name: negative regulation of phagosome maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of phagosome maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of phagosome maturation" EXACT [GOC:TermGenie] synonym: "downregulation of phagosome maturation" EXACT [GOC:TermGenie] synonym: "inhibition of phagosome maturation" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905162 ! regulation of phagosome maturation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090382 ! phagosome maturation relationship: negatively_regulates GO:0090382 ! phagosome maturation created_by: bf creation_date: 2016-04-25T16:28:11Z [Term] id: GO:1905164 name: positive regulation of phagosome maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of phagosome maturation" NARROW [GOC:TermGenie] synonym: "up regulation of phagosome maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of phagosome maturation" EXACT [GOC:TermGenie] synonym: "upregulation of phagosome maturation" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1905162 ! regulation of phagosome maturation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090382 ! phagosome maturation relationship: positively_regulates GO:0090382 ! phagosome maturation created_by: bf creation_date: 2016-04-25T16:28:19Z [Term] id: GO:1905165 name: regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937] synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905146 ! lysosomal protein catabolic process relationship: regulates GO:1905146 ! lysosomal protein catabolic process created_by: bf creation_date: 2016-04-26T12:10:01Z [Term] id: GO:1905166 name: negative regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905146 ! lysosomal protein catabolic process relationship: negatively_regulates GO:1905146 ! lysosomal protein catabolic process created_by: bf creation_date: 2016-04-26T12:10:10Z [Term] id: GO:1905167 name: positive regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905146 ! lysosomal protein catabolic process relationship: positively_regulates GO:1905146 ! lysosomal protein catabolic process created_by: bf creation_date: 2016-04-26T12:10:19Z [Term] id: GO:1905168 name: positive regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299] synonym: "activation of double-strand break repair via homologous recombination" NARROW [GOC:TermGenie] synonym: "activation of HDR" NARROW [GOC:TermGenie] synonym: "activation of homologous recombinational repair" NARROW [GOC:TermGenie] synonym: "activation of homology-directed repair" NARROW [GOC:TermGenie] synonym: "activation of HRR" NARROW [GOC:TermGenie] synonym: "activation of Rad51-dependent recombinational repair" NARROW [GOC:TermGenie] synonym: "activation of Rhp51-dependent recombinational repair" NARROW [GOC:TermGenie] synonym: "positive regulation of HDR" EXACT [GOC:TermGenie] synonym: "positive regulation of homologous recombinational repair" EXACT [GOC:TermGenie] synonym: "positive regulation of homology-directed repair" EXACT [GOC:TermGenie] synonym: "positive regulation of HRR" EXACT [GOC:TermGenie] synonym: "positive regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "positive regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "up regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "up regulation of HDR" EXACT [GOC:TermGenie] synonym: "up regulation of homologous recombinational repair" EXACT [GOC:TermGenie] synonym: "up regulation of homology-directed repair" EXACT [GOC:TermGenie] synonym: "up regulation of HRR" EXACT [GOC:TermGenie] synonym: "up regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "up regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "up-regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "up-regulation of HDR" EXACT [GOC:TermGenie] synonym: "up-regulation of homologous recombinational repair" EXACT [GOC:TermGenie] synonym: "up-regulation of homology-directed repair" EXACT [GOC:TermGenie] synonym: "up-regulation of HRR" EXACT [GOC:TermGenie] synonym: "up-regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "up-regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "upregulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] synonym: "upregulation of HDR" EXACT [GOC:TermGenie] synonym: "upregulation of homologous recombinational repair" EXACT [GOC:TermGenie] synonym: "upregulation of homology-directed repair" EXACT [GOC:TermGenie] synonym: "upregulation of HRR" EXACT [GOC:TermGenie] synonym: "upregulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] synonym: "upregulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:2000781 ! positive regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination relationship: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination created_by: mah creation_date: 2016-04-27T12:48:47Z [Term] id: GO:1905169 name: regulation of protein localization to phagocytic vesicle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905161 ! protein localization to phagocytic vesicle relationship: regulates GO:1905161 ! protein localization to phagocytic vesicle created_by: bf creation_date: 2016-05-02T18:38:13Z [Term] id: GO:1905170 name: negative regulation of protein localization to phagocytic vesicle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to phagosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment to phagosome" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905161 ! protein localization to phagocytic vesicle relationship: negatively_regulates GO:1905161 ! protein localization to phagocytic vesicle created_by: bf creation_date: 2016-05-02T18:38:22Z [Term] id: GO:1905171 name: positive regulation of protein localization to phagocytic vesicle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671] synonym: "activation of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to phagosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment to phagosome" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to phagosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905161 ! protein localization to phagocytic vesicle relationship: positively_regulates GO:1905161 ! protein localization to phagocytic vesicle created_by: bf creation_date: 2016-05-02T18:38:30Z [Term] id: GO:1905172 name: RISC complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RISC complex." [GO_REF:000102, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364] synonym: "RNA-induced silencing complex binding" EXACT [GOC:TermGenie] is_a: GO:0043021 ! ribonucleoprotein complex binding created_by: bf creation_date: 2016-05-02T19:27:02Z [Term] id: GO:1905173 name: eukaryotic translation initiation factor 2B complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex." [GO_REF:0000079, GOC:TermGenie, PMID:27023709] synonym: "eIF-2B assembly" EXACT [GOC:TermGenie] synonym: "eIF-2B formation" EXACT [GOC:TermGenie] synonym: "eif2B assembly" EXACT [GOC:TermGenie] synonym: "eif2B formation" EXACT [GOC:TermGenie] synonym: "eukaryotic translation initiation factor 2B complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2016-05-03T11:00:21Z [Term] id: GO:1905174 name: regulation of vascular smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] is_a: GO:0050793 ! regulation of developmental process is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation relationship: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:31:57Z [Term] id: GO:1905175 name: negative regulation of vascular smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1900240 ! negative regulation of phenotypic switching is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation relationship: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:32:05Z [Term] id: GO:1905176 name: positive regulation of vascular smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1900241 ! positive regulation of phenotypic switching is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation relationship: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:32:13Z [Term] id: GO:1905177 name: tracheary element differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a tracheary element." [GO_REF:0000086, GOC:TermGenie, PMID:20659276] is_a: GO:0030154 ! cell differentiation created_by: tb creation_date: 2016-05-04T22:14:33Z [Term] id: GO:1905178 name: regulation of cardiac muscle tissue regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061041 ! regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061026 ! cardiac muscle tissue regeneration relationship: regulates GO:0061026 ! cardiac muscle tissue regeneration created_by: rph creation_date: 2016-05-05T11:30:48Z [Term] id: GO:1905179 name: negative regulation of cardiac muscle tissue regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] synonym: "down regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration relationship: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration created_by: rph creation_date: 2016-05-05T11:30:57Z [Term] id: GO:1905180 name: positive regulation of cardiac muscle tissue regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] synonym: "activation of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration relationship: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration created_by: rph creation_date: 2016-05-05T11:31:06Z [Term] id: GO:1905181 name: regulation of urease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137] synonym: "regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009039 ! urease activity relationship: regulates GO:0009039 ! urease activity created_by: tb creation_date: 2016-05-09T23:15:54Z [Term] id: GO:1905182 name: positive regulation of urease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137] synonym: "activation of urea amidohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of urease activity" NARROW [GOC:TermGenie] synonym: "positive regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of urease activity" EXACT [GOC:TermGenie] synonym: "up-regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of urease activity" EXACT [GOC:TermGenie] synonym: "upregulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of urease activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1905181 ! regulation of urease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009039 ! urease activity relationship: positively_regulates GO:0009039 ! urease activity created_by: tb creation_date: 2016-05-09T23:16:03Z [Term] id: GO:1905183 name: negative regulation of protein serine/threonine phosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131] synonym: "down regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "downregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "inhibition of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie] synonym: "inhibition of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004722 ! protein serine/threonine phosphatase activity relationship: negatively_regulates GO:0004722 ! protein serine/threonine phosphatase activity created_by: mah creation_date: 2016-05-10T15:28:04Z [Term] id: GO:1905184 name: positive regulation of protein serine/threonine phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131] synonym: "activation of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004722 ! protein serine/threonine phosphatase activity relationship: positively_regulates GO:0004722 ! protein serine/threonine phosphatase activity created_by: mah creation_date: 2016-05-10T15:28:13Z [Term] id: GO:1905185 name: microtubule sliding involved in mitotic metaphase chromosome recapture namespace: biological_process def: "Any microtubule sliding that is involved in mitotic metaphase chromosome recapture." [GO_REF:0000060, GOC:TermGenie, PMID:18256284] synonym: "microtubule sliding involved in kinetochore retrieval" EXACT [GOC:TermGenie] synonym: "microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body" EXACT [GOC:TermGenie] synonym: "microtubule sliding involved in sister kinetochore recapture" EXACT [GOC:TermGenie] is_a: GO:0051012 ! microtubule sliding is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051012 ! microtubule sliding intersection_of: part_of GO:1990942 ! mitotic metaphase chromosome recapture relationship: part_of GO:1990942 ! mitotic metaphase chromosome recapture created_by: vw creation_date: 2016-05-10T16:08:25Z [Term] id: GO:1905186 name: regulation of metaphase/anaphase transition of meiosis I namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] synonym: "regulation of first meiotic metaphase/anaphase transition" RELATED [GOC:TermGenie] synonym: "regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990949 ! metaphase/anaphase transition of meiosis I relationship: regulates GO:1990949 ! metaphase/anaphase transition of meiosis I created_by: vw creation_date: 2016-05-10T16:32:03Z [Term] id: GO:1905187 name: negative regulation of metaphase/anaphase transition of meiosis I namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I relationship: negatively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I created_by: vw creation_date: 2016-05-10T16:32:11Z [Term] id: GO:1905188 name: positive regulation of metaphase/anaphase transition of meiosis I namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] synonym: "positive regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I relationship: positively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I created_by: vw creation_date: 2016-05-10T16:32:19Z [Term] id: GO:1905189 name: regulation of metaphase/anaphase transition of meiosis II namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] synonym: "regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990950 ! metaphase/anaphase transition of meiosis II relationship: regulates GO:1990950 ! metaphase/anaphase transition of meiosis II created_by: vw creation_date: 2016-05-10T16:46:49Z [Term] id: GO:1905190 name: negative regulation of metaphase/anaphase transition of meiosis II namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] synonym: "negative regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II relationship: negatively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II created_by: vw creation_date: 2016-05-10T16:46:57Z [Term] id: GO:1905191 name: positive regulation of metaphase/anaphase transition of meiosis II namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] synonym: "positive regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II relationship: positively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II created_by: vw creation_date: 2016-05-10T16:47:05Z [Term] id: GO:1905192 name: regulation of chloroplast fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010020 ! chloroplast fission relationship: regulates GO:0010020 ! chloroplast fission created_by: lr creation_date: 2016-05-10T19:07:34Z [Term] id: GO:1905193 name: negative regulation of chloroplast fission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie] synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie] synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010020 ! chloroplast fission relationship: negatively_regulates GO:0010020 ! chloroplast fission created_by: lr creation_date: 2016-05-10T19:07:43Z [Term] id: GO:1905194 name: positive regulation of chloroplast fission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "activation of chloroplast division" NARROW [GOC:TermGenie] synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010020 ! chloroplast fission relationship: positively_regulates GO:0010020 ! chloroplast fission created_by: lr creation_date: 2016-05-10T19:07:51Z [Term] id: GO:1905195 name: obsolete regulation of ATPase activity, uncoupled namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917] comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. synonym: "regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2016-05-12T08:01:20Z [Term] id: GO:1905196 name: obsolete positive regulation of ATPase activity, uncoupled namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917] comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. synonym: "activation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] synonym: "activation of ATPase activity, uncoupled" NARROW [GOC:TermGenie] synonym: "positive regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] synonym: "up regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] synonym: "up regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] synonym: "up-regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] synonym: "upregulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] synonym: "upregulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2016-05-12T08:01:28Z [Term] id: GO:1905197 name: endocannabinoid signaling pathway involved in retrograde trans-synaptic signaling namespace: biological_process def: "Any endocannabinoid signaling pathway that is involved in retrograde trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807] synonym: "endocannabinoid signalling pathway involved in retrograde trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie] is_a: GO:1905129 ! endocannabinoid signaling pathway involved in trans-synaptic signaling intersection_of: GO:0071926 ! endocannabinoid signaling pathway intersection_of: part_of GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid relationship: part_of GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid created_by: dos creation_date: 2016-05-12T14:29:38Z [Term] id: GO:1905198 name: manchette assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a manchette." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866] synonym: "manchette formation" EXACT [GOC:TermGenie] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0007286 ! spermatid development created_by: krc creation_date: 2016-05-12T15:19:08Z [Term] id: GO:1905199 name: manchette disassembly namespace: biological_process def: "The disaggregation of a manchette into its constituent components." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development created_by: krc creation_date: 2016-05-12T15:19:16Z [Term] id: GO:1905200 name: gibberellic acid transmembrane transport namespace: biological_process def: "The directed movement of gibberellic acid across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:27139299] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046865 ! terpenoid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: lr creation_date: 2016-05-12T18:20:04Z [Term] id: GO:1905201 name: gibberellin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gibberellin from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:27139299] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity created_by: lr creation_date: 2016-05-12T18:20:13Z [Term] id: GO:1905202 name: methylcrotonoyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity." [GO_REF:0000088, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22158123] is_a: GO:1902494 ! catalytic complex created_by: bf creation_date: 2016-05-16T11:03:20Z [Term] id: GO:1905203 name: regulation of connective tissue replacement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097709 ! connective tissue replacement relationship: regulates GO:0097709 ! connective tissue replacement created_by: bc creation_date: 2016-05-17T09:54:18Z [Term] id: GO:1905204 name: negative regulation of connective tissue replacement namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] synonym: "down regulation of connective tissue replacement" EXACT [GOC:TermGenie] synonym: "down-regulation of connective tissue replacement" EXACT [GOC:TermGenie] synonym: "downregulation of connective tissue replacement" EXACT [GOC:TermGenie] synonym: "inhibition of connective tissue replacement" NARROW [GOC:TermGenie] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:1905203 ! regulation of connective tissue replacement intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097709 ! connective tissue replacement relationship: negatively_regulates GO:0097709 ! connective tissue replacement created_by: bc creation_date: 2016-05-17T09:54:27Z [Term] id: GO:1905205 name: positive regulation of connective tissue replacement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] synonym: "activation of connective tissue replacement" NARROW [GOC:TermGenie] synonym: "up regulation of connective tissue replacement" EXACT [GOC:TermGenie] synonym: "up-regulation of connective tissue replacement" EXACT [GOC:TermGenie] synonym: "upregulation of connective tissue replacement" EXACT [GOC:TermGenie] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:1905203 ! regulation of connective tissue replacement intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097709 ! connective tissue replacement relationship: positively_regulates GO:0097709 ! connective tissue replacement created_by: bc creation_date: 2016-05-17T09:54:35Z [Term] id: GO:1905206 name: positive regulation of hydrogen peroxide-induced cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:20550618] synonym: "activation of cell death in response to H2O2" NARROW [GOC:TermGenie] synonym: "activation of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] synonym: "activation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "positive regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "positive regulation of cell death in response to hydrogen peroxide" EXACT [] synonym: "positive regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "up regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "up regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "up-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "up-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] synonym: "upregulation of cell death in response to H2O2" EXACT [GOC:TermGenie] synonym: "upregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] is_a: GO:1901033 ! positive regulation of response to reactive oxygen species is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death is_a: GO:2001040 ! positive regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide created_by: bc creation_date: 2016-05-20T13:13:39Z [Term] id: GO:1905207 name: regulation of cardiocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035051 ! cardiocyte differentiation relationship: regulates GO:0035051 ! cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:01Z [Term] id: GO:1905208 name: negative regulation of cardiocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035051 ! cardiocyte differentiation relationship: negatively_regulates GO:0035051 ! cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:09Z [Term] id: GO:1905209 name: positive regulation of cardiocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035051 ! cardiocyte differentiation relationship: positively_regulates GO:0035051 ! cardiocyte differentiation created_by: bc creation_date: 2016-06-02T07:20:16Z [Term] id: GO:1905210 name: regulation of fibroblast chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990956 ! fibroblast chemotaxis relationship: regulates GO:1990956 ! fibroblast chemotaxis created_by: sl creation_date: 2016-06-02T20:08:42Z [Term] id: GO:1905211 name: negative regulation of fibroblast chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] synonym: "down regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of fibroblast chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1905210 ! regulation of fibroblast chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990956 ! fibroblast chemotaxis relationship: negatively_regulates GO:1990956 ! fibroblast chemotaxis created_by: sl creation_date: 2016-06-02T20:08:51Z [Term] id: GO:1905212 name: positive regulation of fibroblast chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] synonym: "activation of fibroblast chemotaxis" NARROW [GOC:TermGenie] synonym: "up regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] synonym: "up-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] synonym: "upregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1905210 ! regulation of fibroblast chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990956 ! fibroblast chemotaxis relationship: positively_regulates GO:1990956 ! fibroblast chemotaxis created_by: sl creation_date: 2016-06-02T20:08:59Z [Term] id: GO:1905213 name: negative regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:1902340 ! negative regulation of chromosome condensation is_a: GO:1903379 ! regulation of mitotic chromosome condensation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007076 ! mitotic chromosome condensation relationship: negatively_regulates GO:0007076 ! mitotic chromosome condensation created_by: vw creation_date: 2016-06-03T08:41:08Z [Term] id: GO:1905214 name: regulation of RNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003723 ! RNA binding relationship: regulates GO:0003723 ! RNA binding created_by: bf creation_date: 2016-06-06T10:20:56Z [Term] id: GO:1905215 name: negative regulation of RNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of RNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of RNA binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1905214 ! regulation of RNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003723 ! RNA binding relationship: negatively_regulates GO:0003723 ! RNA binding created_by: bf creation_date: 2016-06-06T10:21:04Z [Term] id: GO:1905216 name: positive regulation of RNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] synonym: "activation of RNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1905214 ! regulation of RNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003723 ! RNA binding relationship: positively_regulates GO:0003723 ! RNA binding created_by: bf creation_date: 2016-06-06T10:21:12Z [Term] id: GO:1905217 name: response to astaxanthin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] synonym: "response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:0061476 ! response to anticoagulant created_by: sl creation_date: 2016-06-06T21:30:00Z [Term] id: GO:1905218 name: cellular response to astaxanthin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] synonym: "cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:1905217 ! response to astaxanthin created_by: sl creation_date: 2016-06-06T21:30:09Z [Term] id: GO:1905219 name: regulation of platelet formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "regulation of platelet extrusion" EXACT [GOC:TermGenie] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030220 ! platelet formation relationship: regulates GO:0030220 ! platelet formation created_by: sl creation_date: 2016-06-06T22:15:46Z [Term] id: GO:1905220 name: negative regulation of platelet formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "down regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "down regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "down-regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "down-regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "downregulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "downregulation of platelet formation" EXACT [GOC:TermGenie] synonym: "inhibition of platelet extrusion" NARROW [GOC:TermGenie] synonym: "inhibition of platelet formation" NARROW [GOC:TermGenie] synonym: "negative regulation of platelet extrusion" EXACT [GOC:TermGenie] is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1905219 ! regulation of platelet formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030220 ! platelet formation relationship: negatively_regulates GO:0030220 ! platelet formation created_by: sl creation_date: 2016-06-06T22:15:54Z [Term] id: GO:1905221 name: positive regulation of platelet formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "activation of platelet extrusion" NARROW [GOC:TermGenie] synonym: "activation of platelet formation" NARROW [GOC:TermGenie] synonym: "positive regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "upregulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "upregulation of platelet formation" EXACT [GOC:TermGenie] is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1905219 ! regulation of platelet formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030220 ! platelet formation relationship: positively_regulates GO:0030220 ! platelet formation created_by: sl creation_date: 2016-06-06T22:16:02Z [Term] id: GO:1905222 name: atrioventricular canal morphogenesis namespace: biological_process def: "The developmental process by which an atrioventricular canal is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439] synonym: "atrial canal morphogenesis" EXACT [GOC:TermGenie] synonym: "atrio-ventricular canal morphogenesis" EXACT [GOC:TermGenie] synonym: "AV canal morphogenesis" EXACT [GOC:TermGenie] synonym: "AVC morphogenesis" EXACT [GOC:TermGenie] synonym: "canalis atrioventricularis morphogenesis" RELATED [GOC:TermGenie] synonym: "ependymal canal morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: rl creation_date: 2016-06-07T09:09:51Z [Term] id: GO:1905223 name: epicardium morphogenesis namespace: biological_process def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie] synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie] synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: rl creation_date: 2016-06-07T10:02:32Z [Term] id: GO:1905224 name: clathrin-coated pit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "coated pit assembly" EXACT [GOC:TermGenie] synonym: "coated pit formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly relationship: has_part GO:0010324 ! membrane invagination relationship: has_part GO:0048268 ! clathrin coat assembly created_by: bf creation_date: 2016-06-07T11:33:28Z [Term] id: GO:1905225 name: response to thyrotropin-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:21382270] synonym: "response to protirelin" EXACT [] synonym: "response to TRH" RELATED [] is_a: GO:0043434 ! response to peptide hormone created_by: pr creation_date: 2016-06-07T12:11:28Z [Term] id: GO:1905226 name: regulation of adhesion of symbiont to host epithelial cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell relationship: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell created_by: pga creation_date: 2016-06-07T13:15:08Z [Term] id: GO:1905227 name: negative regulation of adhesion of symbiont to host epithelial cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] synonym: "down regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] synonym: "down-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] synonym: "downregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] synonym: "inhibition of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:1905226 ! regulation of adhesion of symbiont to host epithelial cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell relationship: negatively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell created_by: pga creation_date: 2016-06-07T13:15:16Z [Term] id: GO:1905228 name: positive regulation of adhesion of symbiont to host epithelial cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] synonym: "activation of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie] synonym: "up regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] synonym: "up-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] synonym: "upregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:1905226 ! regulation of adhesion of symbiont to host epithelial cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell relationship: positively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell created_by: pga creation_date: 2016-06-07T13:15:24Z [Term] id: GO:1905229 name: cellular response to thyrotropin-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] synonym: "cellular response to protirelin" EXACT [] synonym: "cellular response to TRH" RELATED [] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1905225 ! response to thyrotropin-releasing hormone created_by: sl creation_date: 2016-06-07T16:14:10Z [Term] id: GO:1905230 name: response to borneol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909] is_a: GO:0033993 ! response to lipid created_by: sl creation_date: 2016-06-07T17:18:36Z [Term] id: GO:1905231 name: cellular response to borneol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1905230 ! response to borneol created_by: sl creation_date: 2016-06-07T17:18:44Z [Term] id: GO:1905232 name: cellular response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137] synonym: "cellular response to L-glutamate(1-)" RELATED [] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1902065 ! response to L-glutamate created_by: sl creation_date: 2016-06-07T17:30:08Z [Term] id: GO:1905233 name: response to codeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014072 ! response to isoquinoline alkaloid is_a: GO:0042493 ! response to drug is_a: GO:0060359 ! response to ammonium ion created_by: sl creation_date: 2016-06-07T21:26:45Z [Term] id: GO:1905234 name: cellular response to codeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071242 ! cellular response to ammonium ion is_a: GO:0071317 ! cellular response to isoquinoline alkaloid is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1905233 ! response to codeine created_by: sl creation_date: 2016-06-07T21:26:53Z [Term] id: GO:1905235 name: response to quercetin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] is_a: GO:0009725 ! response to hormone is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1905395 ! response to flavonoid created_by: sl creation_date: 2016-06-07T21:29:40Z [Term] id: GO:1905236 name: cellular response to quercetin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1905235 ! response to quercetin is_a: GO:1905396 ! cellular response to flavonoid created_by: sl creation_date: 2016-06-07T21:29:48Z [Term] id: GO:1905237 name: response to cyclosporin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] synonym: "response to cyclophilin" EXACT [] is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: sl creation_date: 2016-06-07T21:32:06Z [Term] id: GO:1905238 name: cellular response to cyclosporin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] synonym: "cellular response to cyclophilin" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1901653 ! cellular response to peptide is_a: GO:1905237 ! response to cyclosporin A created_by: sl creation_date: 2016-06-07T21:32:14Z [Term] id: GO:1905239 name: regulation of canonical Wnt signaling pathway involved in osteoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] synonym: "regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] is_a: GO:0045667 ! regulation of osteoblast differentiation is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation relationship: regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation created_by: rph creation_date: 2016-06-08T10:26:33Z [Term] id: GO:1905240 name: negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] synonym: "down regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] is_a: GO:0045668 ! negative regulation of osteoblast differentiation is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:1905239 ! regulation of canonical Wnt signaling pathway involved in osteoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation relationship: negatively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation created_by: rph creation_date: 2016-06-08T10:26:41Z [Term] id: GO:1905241 name: positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] synonym: "activation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "activation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] is_a: GO:0045669 ! positive regulation of osteoblast differentiation is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway is_a: GO:1905239 ! regulation of canonical Wnt signaling pathway involved in osteoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation relationship: positively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation created_by: rph creation_date: 2016-06-08T10:26:49Z [Term] id: GO:1905242 name: response to 3,3',5-triiodo-L-thyronine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] synonym: "response to Liothyronin" EXACT [] synonym: "response to Liothyronine" EXACT [] synonym: "response to Liothyroninum" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid is_a: GO:0097066 ! response to thyroid hormone created_by: sl creation_date: 2016-06-08T17:42:04Z [Term] id: GO:1905243 name: cellular response to 3,3',5-triiodo-L-thyronine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] synonym: "cellular response to Liothyronin" EXACT [] synonym: "cellular response to Liothyronine" EXACT [] synonym: "cellular response to Liothyroninum" EXACT [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097067 ! cellular response to thyroid hormone stimulus is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine created_by: sl creation_date: 2016-06-08T17:42:12Z [Term] id: GO:1905244 name: regulation of modification of synaptic structure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of modification of synaptic structure." [GO_REF:0000058, GOC:TermGenie, PMID:25164660] subset: goslim_synapse synonym: "regulation of synapse remodelling" EXACT [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099563 ! modification of synaptic structure relationship: regulates GO:0099563 ! modification of synaptic structure created_by: dos creation_date: 2016-06-09T09:43:40Z [Term] id: GO:1905245 name: regulation of aspartic-type peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070001 ! aspartic-type peptidase activity relationship: regulates GO:0070001 ! aspartic-type peptidase activity created_by: jl creation_date: 2016-06-09T11:55:39Z [Term] id: GO:1905246 name: negative regulation of aspartic-type peptidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] synonym: "down regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] synonym: "inhibition of aspartic-type peptidase activity" NARROW [GOC:TermGenie] synonym: "pepsin inhibitor" RELATED [] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:1905245 ! regulation of aspartic-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070001 ! aspartic-type peptidase activity relationship: negatively_regulates GO:0070001 ! aspartic-type peptidase activity created_by: jl creation_date: 2016-06-09T11:55:47Z [Term] id: GO:1905247 name: positive regulation of aspartic-type peptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] synonym: "activation of aspartic-type peptidase activity" NARROW [GOC:TermGenie] synonym: "up regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] synonym: "upregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:1905245 ! regulation of aspartic-type peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070001 ! aspartic-type peptidase activity relationship: positively_regulates GO:0070001 ! aspartic-type peptidase activity created_by: jl creation_date: 2016-06-09T11:55:55Z [Term] id: GO:1905248 name: obsolete regulation of memory namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "modulation of memory" NARROW [] is_obsolete: true created_by: ha creation_date: 2016-06-09T13:54:38Z [Term] id: GO:1905249 name: obsolete negative regulation of memory namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "inhibition of memory" NARROW [GOC:TermGenie] synonym: "suppression of memory" EXACT [] is_obsolete: true created_by: ha creation_date: 2016-06-09T13:54:45Z [Term] id: GO:1905250 name: obsolete positive regulation of memory namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "enhancement of memory" NARROW [] is_obsolete: true created_by: ha creation_date: 2016-06-09T13:54:53Z [Term] id: GO:1905251 name: epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "Any epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: GO:0007173 ! epidermal growth factor receptor signaling pathway intersection_of: part_of GO:0003015 ! heart process relationship: part_of GO:0003015 ! heart process created_by: bc creation_date: 2016-06-10T09:20:54Z [Term] id: GO:1905252 name: obsolete regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] is_obsolete: true created_by: bc creation_date: 2016-06-10T09:21:02Z [Term] id: GO:1905253 name: obsolete negative regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any negative regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] is_obsolete: true created_by: bc creation_date: 2016-06-10T09:21:10Z [Term] id: GO:1905254 name: obsolete positive regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "OBSOLETE. Any positive regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] is_obsolete: true created_by: bc creation_date: 2016-06-10T09:21:18Z [Term] id: GO:1905255 name: regulation of RNA binding transcription factor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] synonym: "regulation of transcription factor activity" BROAD [GOC:TermGenie] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001070 ! RNA-binding transcription regulator activity relationship: regulates GO:0001070 ! RNA-binding transcription regulator activity created_by: bf creation_date: 2016-06-13T11:29:11Z [Term] id: GO:1905256 name: negative regulation of RNA binding transcription factor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "downregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA binding transcription factor activity" NARROW [GOC:TermGenie] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:1905255 ! regulation of RNA binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001070 ! RNA-binding transcription regulator activity relationship: negatively_regulates GO:0001070 ! RNA-binding transcription regulator activity created_by: bf creation_date: 2016-06-13T11:29:20Z [Term] id: GO:1905257 name: positive regulation of RNA binding transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] synonym: "activation of RNA binding transcription factor activity" NARROW [GOC:TermGenie] synonym: "up regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:1905255 ! regulation of RNA binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001070 ! RNA-binding transcription regulator activity relationship: positively_regulates GO:0001070 ! RNA-binding transcription regulator activity created_by: bf creation_date: 2016-06-13T11:29:27Z [Term] id: GO:1905258 name: regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510] synonym: "regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] synonym: "regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress relationship: regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress created_by: bf creation_date: 2016-06-13T17:04:59Z [Term] id: GO:1905259 name: negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510] synonym: "down regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "down regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "down regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "downregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie] synonym: "inhibition of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] synonym: "negative regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress relationship: negatively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress created_by: bf creation_date: 2016-06-13T17:05:07Z [Term] id: GO:1905260 name: positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie] synonym: "activation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "activation of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] synonym: "positive regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "up regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] synonym: "upregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress relationship: positively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress created_by: bf creation_date: 2016-06-13T17:05:15Z [Term] id: GO:1905261 name: regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination relationship: regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination created_by: se creation_date: 2016-06-13T20:45:02Z [Term] id: GO:1905262 name: negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] synonym: "down regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie] is_a: GO:0045128 ! negative regulation of reciprocal meiotic recombination is_a: GO:1903342 ! negative regulation of meiotic DNA double-strand break formation is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination relationship: negatively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination created_by: se creation_date: 2016-06-13T20:45:10Z [Term] id: GO:1905263 name: positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] synonym: "activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination is_a: GO:1903343 ! positive regulation of meiotic DNA double-strand break formation is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination relationship: positively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination created_by: se creation_date: 2016-06-13T20:45:18Z [Term] id: GO:1905264 name: blasticidin S metabolic process namespace: biological_process def: "The chemical reactions and pathways involving blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, https://en.wikipedia.org/wiki/Blasticidin_S, PMID:23874663] synonym: "blasticidin S metabolism" EXACT [GOC:TermGenie] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process created_by: pr creation_date: 2016-06-14T12:47:05Z [Term] id: GO:1905265 name: blasticidin S catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, https://en.wikipedia.org/wiki/Blasticidin_S, PMID:23874663] synonym: "blasticidin S breakdown" EXACT [GOC:TermGenie] synonym: "blasticidin S catabolism" EXACT [GOC:TermGenie] synonym: "blasticidin S degradation" EXACT [GOC:TermGenie] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process is_a: GO:1905264 ! blasticidin S metabolic process created_by: pr creation_date: 2016-06-14T12:47:13Z [Term] id: GO:1905266 name: blasticidin S biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, https://en.wikipedia.org/wiki/Blasticidin_S, PMID:23874663] synonym: "blasticidin S anabolism" EXACT [GOC:TermGenie] synonym: "blasticidin S biosynthesis" EXACT [GOC:TermGenie] synonym: "blasticidin S formation" EXACT [GOC:TermGenie] synonym: "blasticidin S synthesis" EXACT [GOC:TermGenie] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process is_a: GO:1905264 ! blasticidin S metabolic process created_by: pr creation_date: 2016-06-14T12:47:22Z [Term] id: GO:1905267 name: endonucleolytic cleavage involved in tRNA processing namespace: biological_process def: "Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing." [GO_REF:0000060, GOC:TermGenie, PMID:25401760] synonym: "RNA phosphodiester bond hydrolysis, endonucleolytic involved in tRNA maturation" EXACT [GOC:TermGenie] is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic intersection_of: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic intersection_of: part_of GO:0008033 ! tRNA processing relationship: part_of GO:0008033 ! tRNA processing created_by: al creation_date: 2016-06-14T14:54:54Z [Term] id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process alt_id: GO:1903309 def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006325 ! chromatin organization relationship: negatively_regulates GO:0006325 ! chromatin organization created_by: pr creation_date: 2016-06-15T20:14:47Z [Term] id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process alt_id: GO:1903310 def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006325 ! chromatin organization relationship: positively_regulates GO:0006325 ! chromatin organization created_by: pr creation_date: 2016-06-15T20:14:56Z [Term] id: GO:1905270 name: Meynert cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell." [GO_REF:0000086, GOC:TermGenie, PMID:4142639] is_a: GO:0021859 ! pyramidal neuron differentiation is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0021895 ! cerebral cortex neuron differentiation created_by: cjm creation_date: 2016-06-15T23:44:17Z [Term] id: GO:1905271 name: regulation of proton-transporting ATP synthase activity, rotational mechanism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] synonym: "regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0051338 ! regulation of transferase activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism relationship: regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism created_by: als creation_date: 2016-06-16T12:09:49Z [Term] id: GO:1905272 name: negative regulation of proton-transporting ATP synthase activity, rotational mechanism namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] synonym: "down regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "down regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "down regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "down-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "down-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "downregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "downregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "downregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "inhibition of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] synonym: "inhibition of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie] synonym: "inhibition of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] synonym: "negative regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism relationship: negatively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism created_by: als creation_date: 2016-06-16T12:09:57Z [Term] id: GO:1905273 name: positive regulation of proton-transporting ATP synthase activity, rotational mechanism namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] synonym: "activation of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] synonym: "activation of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie] synonym: "activation of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] synonym: "positive regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "positive regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "up regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "up regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "up-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "up-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "upregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism relationship: positively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism created_by: als creation_date: 2016-06-16T12:10:05Z [Term] id: GO:1905274 name: regulation of modification of postsynaptic actin cytoskeleton namespace: biological_process def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton." [GO_REF:0000058, GOC:TermGenie, PMID:21068295] subset: goslim_synapse synonym: "regulation of postsynaptic actin cytoskeleton remodelling" EXACT [GOC:TermGenie] is_a: GO:0099159 ! regulation of modification of postsynaptic structure intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098885 ! modification of postsynaptic actin cytoskeleton relationship: regulates GO:0098885 ! modification of postsynaptic actin cytoskeleton created_by: dos creation_date: 2016-06-16T22:34:25Z [Term] id: GO:1905275 name: Rohon-Beard neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron." [GO_REF:0000086, GOC:TermGenie, ZFIN:ZDB-PUB-120807-45] is_a: GO:0030182 ! neuron differentiation created_by: cjm creation_date: 2016-06-16T23:17:04Z [Term] id: GO:1905276 name: regulation of epithelial tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072175 ! epithelial tube formation relationship: regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:41Z [Term] id: GO:1905277 name: negative regulation of epithelial tube formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072175 ! epithelial tube formation relationship: negatively_regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:49Z [Term] id: GO:1905278 name: positive regulation of epithelial tube formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072175 ! epithelial tube formation relationship: positively_regulates GO:0072175 ! epithelial tube formation created_by: bhm creation_date: 2016-06-20T09:35:57Z [Term] id: GO:1905279 name: regulation of retrograde transport, endosome to Golgi namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371] synonym: "regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042147 ! retrograde transport, endosome to Golgi relationship: regulates GO:0042147 ! retrograde transport, endosome to Golgi created_by: bf creation_date: 2016-06-20T12:25:29Z [Term] id: GO:1905280 name: negative regulation of retrograde transport, endosome to Golgi namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "down regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] synonym: "inhibition of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie] synonym: "inhibition of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie] synonym: "negative regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] is_a: GO:1903650 ! negative regulation of cytoplasmic transport is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042147 ! retrograde transport, endosome to Golgi relationship: negatively_regulates GO:0042147 ! retrograde transport, endosome to Golgi created_by: bf creation_date: 2016-06-20T12:25:37Z [Term] id: GO:1905281 name: positive regulation of retrograde transport, endosome to Golgi namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie] synonym: "activation of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie] synonym: "positive regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "up regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "up regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] is_a: GO:1903651 ! positive regulation of cytoplasmic transport is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042147 ! retrograde transport, endosome to Golgi relationship: positively_regulates GO:0042147 ! retrograde transport, endosome to Golgi created_by: bf creation_date: 2016-06-20T12:25:44Z [Term] id: GO:1905282 name: regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0044057 ! regulation of system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process relationship: regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process created_by: bc creation_date: 2016-06-20T14:40:41Z [Term] id: GO:1905283 name: negative regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "down regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "inhibition of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process relationship: negatively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process created_by: bc creation_date: 2016-06-20T14:40:49Z [Term] id: GO:1905284 name: positive regulation of epidermal growth factor receptor signaling pathway involved in heart process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "activation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process relationship: positively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process created_by: bc creation_date: 2016-06-20T14:40:57Z [Term] id: GO:1905285 name: fibrous ring of heart morphogenesis namespace: biological_process def: "The developmental process by which a fibrous ring of heart is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16037571] synonym: "annulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] synonym: "anulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] synonym: "anulus fibrosus of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "aortic annulus morphogenesis" RELATED [GOC:TermGenie] synonym: "atrioventricular ring morphogenesis" RELATED [GOC:TermGenie] synonym: "coronary tendon morphogenesis" RELATED [GOC:TermGenie] synonym: "Lower's ring morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0048729 ! tissue morphogenesis created_by: rl creation_date: 2016-06-21T09:46:54Z [Term] id: GO:1905286 name: serine-type peptidase complex namespace: cellular_component def: "A protein complex which is capable of serine-type peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965] comment: An example of this is F7 in human (P08709) in PMID:18640965 (inferred from direct assay). synonym: "Factor VII - TF complex" NARROW [] is_a: GO:1905368 ! peptidase complex created_by: bhm creation_date: 2016-06-21T14:20:20Z [Term] id: GO:1905287 name: positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation namespace: biological_process def: "Any positive regulation of G2/M transition of mitotic cell cycle that is involved in cellular response to nitrogen starvation." [GO_REF:0000060, GOC:TermGenie, PMID:26776736] synonym: "positive regulation of mitotic entry involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie] is_a: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle intersection_of: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle intersection_of: part_of GO:0006995 ! cellular response to nitrogen starvation relationship: part_of GO:0006995 ! cellular response to nitrogen starvation created_by: al creation_date: 2016-06-21T17:19:33Z [Term] id: GO:1905288 name: vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034390 ! smooth muscle cell apoptotic process created_by: rph creation_date: 2016-06-23T13:24:20Z [Term] id: GO:1905289 name: regulation of CAMKK-AMPK signaling cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] synonym: "regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] is_a: GO:0050848 ! regulation of calcium-mediated signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061762 ! CAMKK-AMPK signaling cascade relationship: regulates GO:0061762 ! CAMKK-AMPK signaling cascade created_by: sl creation_date: 2016-06-23T20:36:55Z [Term] id: GO:1905290 name: negative regulation of CAMKK-AMPK signaling cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] synonym: "down regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "down regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "down-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "downregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade relationship: negatively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade created_by: sl creation_date: 2016-06-23T20:37:03Z [Term] id: GO:1905291 name: positive regulation of CAMKK-AMPK signaling cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] synonym: "activation of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "up regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "up-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] synonym: "upregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade relationship: positively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade created_by: sl creation_date: 2016-06-23T20:37:10Z [Term] id: GO:1905292 name: regulation of neural crest cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014033 ! neural crest cell differentiation relationship: regulates GO:0014033 ! neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:01Z [Term] id: GO:1905293 name: negative regulation of neural crest cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014033 ! neural crest cell differentiation relationship: negatively_regulates GO:0014033 ! neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:09Z [Term] id: GO:1905294 name: positive regulation of neural crest cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014033 ! neural crest cell differentiation relationship: positively_regulates GO:0014033 ! neural crest cell differentiation created_by: rl creation_date: 2016-06-28T15:02:16Z [Term] id: GO:1905295 name: regulation of neural crest cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0090299 ! regulation of neural crest formation is_a: GO:1905292 ! regulation of neural crest cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014036 ! neural crest cell fate specification relationship: regulates GO:0014036 ! neural crest cell fate specification created_by: rl creation_date: 2016-06-28T15:14:40Z [Term] id: GO:1905296 name: negative regulation of neural crest cell fate specification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "down regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] synonym: "down-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] synonym: "downregulation of neural crest cell fate specification" EXACT [GOC:TermGenie] synonym: "inhibition of neural crest cell fate specification" NARROW [GOC:TermGenie] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0090301 ! negative regulation of neural crest formation is_a: GO:1905293 ! negative regulation of neural crest cell differentiation is_a: GO:1905295 ! regulation of neural crest cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014036 ! neural crest cell fate specification relationship: negatively_regulates GO:0014036 ! neural crest cell fate specification created_by: rl creation_date: 2016-06-28T15:14:49Z [Term] id: GO:1905297 name: positive regulation of neural crest cell fate specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "activation of neural crest cell fate specification" NARROW [GOC:TermGenie] synonym: "up regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] synonym: "up-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] synonym: "upregulation of neural crest cell fate specification" EXACT [GOC:TermGenie] is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:0090300 ! positive regulation of neural crest formation is_a: GO:1905294 ! positive regulation of neural crest cell differentiation is_a: GO:1905295 ! regulation of neural crest cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014036 ! neural crest cell fate specification relationship: positively_regulates GO:0014036 ! neural crest cell fate specification created_by: rl creation_date: 2016-06-28T15:14:57Z [Term] id: GO:1905298 name: regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060576 ! intestinal epithelial cell development relationship: regulates GO:0060576 ! intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:40:47Z [Term] id: GO:1905299 name: negative regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060576 ! intestinal epithelial cell development relationship: negatively_regulates GO:0060576 ! intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:40:55Z [Term] id: GO:1905300 name: positive regulation of intestinal epithelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905298 ! regulation of intestinal epithelial cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060576 ! intestinal epithelial cell development relationship: positively_regulates GO:0060576 ! intestinal epithelial cell development created_by: rph creation_date: 2016-06-30T11:41:02Z [Term] id: GO:1905301 name: regulation of macropinocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] synonym: "regulation of clathrin-independent pinocytosis" BROAD [GOC:TermGenie] is_a: GO:0048548 ! regulation of pinocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044351 ! macropinocytosis relationship: regulates GO:0044351 ! macropinocytosis created_by: pad creation_date: 2016-07-04T14:16:32Z [Term] id: GO:1905302 name: negative regulation of macropinocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] synonym: "down regulation of macropinocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of macropinocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of macropinocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of macropinocytosis" NARROW [GOC:TermGenie] is_a: GO:0048550 ! negative regulation of pinocytosis is_a: GO:1905301 ! regulation of macropinocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044351 ! macropinocytosis relationship: negatively_regulates GO:0044351 ! macropinocytosis created_by: pad creation_date: 2016-07-04T14:16:41Z [Term] id: GO:1905303 name: positive regulation of macropinocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] synonym: "activation of macropinocytosis" NARROW [GOC:TermGenie] synonym: "up regulation of macropinocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of macropinocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of macropinocytosis" EXACT [GOC:TermGenie] is_a: GO:0048549 ! positive regulation of pinocytosis is_a: GO:1905301 ! regulation of macropinocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044351 ! macropinocytosis relationship: positively_regulates GO:0044351 ! macropinocytosis created_by: pad creation_date: 2016-07-04T14:16:49Z [Term] id: GO:1905304 name: regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0060284 ! regulation of cell development is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902115 ! regulation of organelle assembly is_a: GO:1902903 ! regulation of supramolecular fiber organization is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055003 ! cardiac myofibril assembly relationship: regulates GO:0055003 ! cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:01:49Z [Term] id: GO:1905305 name: negative regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055003 ! cardiac myofibril assembly relationship: negatively_regulates GO:0055003 ! cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:01:58Z [Term] id: GO:1905306 name: positive regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055003 ! cardiac myofibril assembly relationship: positively_regulates GO:0055003 ! cardiac myofibril assembly created_by: rl creation_date: 2016-07-06T10:02:07Z [Term] id: GO:1905307 name: response to miconazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent created_by: al creation_date: 2016-07-06T11:55:22Z [Term] id: GO:1905308 name: cellular response to miconazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1905307 ! response to miconazole created_by: al creation_date: 2016-07-06T11:55:30Z [Term] id: GO:1905309 name: positive regulation of cohesin loading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] synonym: "positive regulation of cohesin association with chromatin" EXACT [GOC:TermGenie] synonym: "positive regulation of cohesin localization to chromatin" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:0045876 ! positive regulation of sister chromatid cohesion is_a: GO:0071922 ! regulation of cohesin loading is_a: GO:0120187 ! positive regulation of protein localization to chromatin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071921 ! cohesin loading relationship: positively_regulates GO:0071921 ! cohesin loading created_by: vw creation_date: 2016-07-08T16:12:18Z [Term] id: GO:1905310 name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0060284 ! regulation of cell development is_a: GO:1905207 ! regulation of cardiocyte differentiation is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis created_by: rl creation_date: 2016-07-11T17:34:26Z [Term] id: GO:1905311 name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:1905293 ! negative regulation of neural crest cell differentiation is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis created_by: rl creation_date: 2016-07-11T17:34:35Z [Term] id: GO:1905312 name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:1905294 ! positive regulation of neural crest cell differentiation is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis created_by: rl creation_date: 2016-07-11T17:34:43Z [Term] id: GO:1905313 name: transforming growth factor beta receptor signaling pathway involved in heart development namespace: biological_process def: "Any transforming growth factor beta receptor signaling pathway that is involved in heart development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16140292] synonym: "TGF-beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "TGF-beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "TGF-beta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "TGF-beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "TGFbeta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "TGFbeta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] synonym: "transforming growth factor beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "transforming growth factor beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] synonym: "transforming growth factor beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway intersection_of: part_of GO:0007507 ! heart development created_by: rl creation_date: 2016-07-11T17:45:38Z [Term] id: GO:1905314 name: semi-lunar valve development namespace: biological_process def: "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885] synonym: "semilunar valve development" EXACT [GOC:TermGenie] synonym: "semilunar valves development" EXACT [GOC:TermGenie] is_a: GO:0003170 ! heart valve development created_by: rl creation_date: 2016-07-11T17:50:44Z [Term] id: GO:1905315 name: cell proliferation involved in endocardial cushion morphogenesis namespace: biological_process def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: rl creation_date: 2016-07-12T13:56:36Z [Term] id: GO:1905316 name: superior endocardial cushion morphogenesis namespace: biological_process def: "The developmental process by which a superior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629] synonym: "dorsal endocardial cushion morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0003203 ! endocardial cushion morphogenesis created_by: rl creation_date: 2016-07-12T14:08:35Z [Term] id: GO:1905317 name: inferior endocardial cushion morphogenesis namespace: biological_process def: "The developmental process by which an inferior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629] synonym: "ventral endocardial cushion morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0003203 ! endocardial cushion morphogenesis created_by: rl creation_date: 2016-07-12T14:14:56Z [Term] id: GO:1905318 name: meiosis I spindle assembly checkpoint namespace: biological_process def: "Any spindle assembly checkpoint that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:26483559] is_a: GO:0033316 ! meiotic spindle assembly checkpoint is_a: GO:0110029 ! negative regulation of meiosis I relationship: negatively_regulates GO:0051755 ! meiotic sister chromatid arm separation created_by: vw creation_date: 2016-07-13T18:25:06Z [Term] id: GO:1905319 name: mesenchymal stem cell migration namespace: biological_process def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476] is_a: GO:0016477 ! cell migration created_by: sl creation_date: 2016-07-14T17:13:02Z [Term] id: GO:1905320 name: regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905319 ! mesenchymal stem cell migration relationship: regulates GO:1905319 ! mesenchymal stem cell migration created_by: sl creation_date: 2016-07-15T22:19:14Z [Term] id: GO:1905321 name: negative regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905319 ! mesenchymal stem cell migration relationship: negatively_regulates GO:1905319 ! mesenchymal stem cell migration created_by: sl creation_date: 2016-07-15T22:19:22Z [Term] id: GO:1905322 name: positive regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905319 ! mesenchymal stem cell migration relationship: positively_regulates GO:1905319 ! mesenchymal stem cell migration created_by: sl creation_date: 2016-07-15T22:19:29Z [Term] id: GO:1905323 name: telomerase holoenzyme complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931] synonym: "telomerase holoenzyme complex formation" EXACT [GOC:TermGenie] is_a: GO:0022618 ! ribonucleoprotein complex assembly created_by: mah creation_date: 2016-07-18T10:38:14Z [Term] id: GO:1905324 name: telomere-telomerase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931] synonym: "telomere-telomerase complex formation" EXACT [GOC:TermGenie] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0032200 ! telomere organization created_by: mah creation_date: 2016-07-18T10:38:22Z [Term] id: GO:1905325 name: regulation of meiosis I spindle assembly checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559] is_a: GO:0060631 ! regulation of meiosis I is_a: GO:0090231 ! regulation of spindle checkpoint is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905318 ! meiosis I spindle assembly checkpoint relationship: regulates GO:1905318 ! meiosis I spindle assembly checkpoint created_by: mah creation_date: 2016-07-20T12:48:40Z [Term] id: GO:1905326 name: positive regulation of meiosis I spindle assembly checkpoint namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559] synonym: "activation of meiosis I spindle assembly checkpoint" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:0090232 ! positive regulation of spindle checkpoint is_a: GO:1905325 ! regulation of meiosis I spindle assembly checkpoint intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905318 ! meiosis I spindle assembly checkpoint relationship: positively_regulates GO:1905318 ! meiosis I spindle assembly checkpoint created_by: mah creation_date: 2016-07-20T12:48:47Z [Term] id: GO:1905327 name: tracheoesophageal septum formation namespace: biological_process def: "The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:9731532] synonym: "esophagotracheal septum formation" EXACT [GOC:TermGenie] synonym: "tracheoesophageal ridges formation" RELATED [GOC:TermGenie] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis created_by: tb creation_date: 2016-07-21T18:18:57Z [Term] id: GO:1905328 name: plant septum development namespace: biological_process def: "The process whose specific outcome is the progression of a septum over time, from its formation to the mature structure." [GO_REF:0000080, GOC:tb, GOC:TermGenie, PMID:4562349] synonym: "dissepiment development" BROAD [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development created_by: tb creation_date: 2016-07-21T18:25:49Z [Term] id: GO:1905329 name: sphingoid long-chain base transport namespace: biological_process def: "The directed movement of a sphingoid long-chain base, sometimes referred to as long-chain base, or sphingoid base, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sphingoid long-chain bases are long-chain aliphatic amines that are the fundamental building blocks of sphingolipids. The main mammalian sphingoid long-chain bases are dihydrosphingosine and sphingosine, while dihydrosphingosine and phytosphingosine are the main sphingoid long-chain bases in yeast." [GO_REF:0000065, GOC:rn, GOC:TermGenie, PMID:27136724] synonym: "dihydrosphingosine transport" NARROW [] synonym: "long-chain base transport" RELATED [] synonym: "phytosphingosine transport" NARROW [] synonym: "sphingoid base(1+) transport" EXACT [] synonym: "sphingoid transport" RELATED [] synonym: "sphingosine transport" NARROW [] is_a: GO:0006869 ! lipid transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport created_by: tb creation_date: 2016-07-22T01:40:59Z [Term] id: GO:1905330 name: regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002009 ! morphogenesis of an epithelium relationship: regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:49Z [Term] id: GO:1905331 name: negative regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002009 ! morphogenesis of an epithelium relationship: negatively_regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:13:57Z [Term] id: GO:1905332 name: positive regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002009 ! morphogenesis of an epithelium relationship: positively_regulates GO:0002009 ! morphogenesis of an epithelium created_by: bhm creation_date: 2016-07-22T07:14:05Z [Term] id: GO:1905333 name: regulation of gastric motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gastric motility." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029] is_a: GO:0044058 ! regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035482 ! gastric motility relationship: regulates GO:0035482 ! gastric motility created_by: als creation_date: 2016-07-22T09:47:31Z [Term] id: GO:1905334 name: Swi5-Sfr1 complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Swi5-Sfr1 complex." [GO_REF:000102, GOC:TermGenie, PMID:16921379] synonym: "Sae3-Mei5 complex binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: al creation_date: 2016-07-25T16:18:58Z [Term] id: GO:1905335 name: regulation of aggrephagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] is_a: GO:0016241 ! regulation of macroautophagy intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035973 ! aggrephagy relationship: regulates GO:0035973 ! aggrephagy created_by: pad creation_date: 2016-07-26T13:41:46Z [Term] id: GO:1905336 name: negative regulation of aggrephagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] synonym: "down regulation of aggrephagy" EXACT [GOC:TermGenie] synonym: "down-regulation of aggrephagy" EXACT [GOC:TermGenie] synonym: "downregulation of aggrephagy" EXACT [GOC:TermGenie] synonym: "inhibition of aggrephagy" NARROW [GOC:TermGenie] is_a: GO:0016242 ! negative regulation of macroautophagy is_a: GO:1905335 ! regulation of aggrephagy intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035973 ! aggrephagy relationship: negatively_regulates GO:0035973 ! aggrephagy created_by: pad creation_date: 2016-07-26T13:41:54Z [Term] id: GO:1905337 name: positive regulation of aggrephagy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] synonym: "activation of aggrephagy" NARROW [GOC:TermGenie] synonym: "up regulation of aggrephagy" EXACT [GOC:TermGenie] synonym: "up-regulation of aggrephagy" EXACT [GOC:TermGenie] synonym: "upregulation of aggrephagy" EXACT [GOC:TermGenie] is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:1905335 ! regulation of aggrephagy intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035973 ! aggrephagy relationship: positively_regulates GO:0035973 ! aggrephagy created_by: pad creation_date: 2016-07-26T13:42:02Z [Term] id: GO:1905338 name: negative regulation of cohesin unloading namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] synonym: "down regulation of cohesin unloading" EXACT [GOC:TermGenie] synonym: "down-regulation of cohesin unloading" EXACT [GOC:TermGenie] synonym: "downregulation of cohesin unloading" EXACT [GOC:TermGenie] synonym: "inhibition of cohesin unloading" NARROW [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:0045876 ! positive regulation of sister chromatid cohesion is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905343 ! regulation of cohesin unloading intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061774 ! cohesin unloading relationship: negatively_regulates GO:0061774 ! cohesin unloading created_by: vw creation_date: 2016-07-26T16:23:58Z [Term] id: GO:1905339 name: positive regulation of cohesin unloading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] synonym: "activation of cohesin unloading" NARROW [GOC:TermGenie] synonym: "up regulation of cohesin unloading" EXACT [GOC:TermGenie] synonym: "up-regulation of cohesin unloading" EXACT [GOC:TermGenie] synonym: "upregulation of cohesin unloading" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905343 ! regulation of cohesin unloading intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061774 ! cohesin unloading relationship: positively_regulates GO:0061774 ! cohesin unloading created_by: vw creation_date: 2016-07-26T16:24:06Z [Term] id: GO:1905340 name: regulation of protein localization to kinetochore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] comment: Q9H211 in Human in PMID:22581055 synonym: "regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034501 ! protein localization to kinetochore relationship: regulates GO:0034501 ! protein localization to kinetochore created_by: es creation_date: 2016-07-27T15:26:36Z [Term] id: GO:1905341 name: negative regulation of protein localization to kinetochore namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] comment: Q9H211 in Human in PMID:22581055 synonym: "down regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "down regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] synonym: "down-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "down-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] synonym: "downregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "downregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to kinetochore" EXACT [GOC:TermGenie] synonym: "inhibition of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to kinetochore" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to kinetochore" NARROW [GOC:TermGenie] synonym: "negative regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905340 ! regulation of protein localization to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034501 ! protein localization to kinetochore relationship: negatively_regulates GO:0034501 ! protein localization to kinetochore created_by: es creation_date: 2016-07-27T15:26:44Z [Term] id: GO:1905342 name: positive regulation of protein localization to kinetochore namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] comment: Q9H211 in Human in PMID:22581055 synonym: "activation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to kinetochore" NARROW [GOC:TermGenie] synonym: "activation of protein localization to kinetochore" NARROW [GOC:TermGenie] synonym: "positive regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "up regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "up regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] synonym: "up-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "up-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] synonym: "upregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] synonym: "upregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to kinetochore" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905340 ! regulation of protein localization to kinetochore intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034501 ! protein localization to kinetochore relationship: positively_regulates GO:0034501 ! protein localization to kinetochore created_by: es creation_date: 2016-07-27T15:26:51Z [Term] id: GO:1905343 name: regulation of cohesin unloading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0007063 ! regulation of sister chromatid cohesion is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061774 ! cohesin unloading relationship: regulates GO:0061774 ! cohesin unloading created_by: vw creation_date: 2016-07-29T10:17:50Z [Term] id: GO:1905344 name: prostaglandin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prostaglandin." [GO_REF:0000068, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25290914] synonym: "prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "prostaglandin degradation" EXACT [GOC:TermGenie] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:1901523 ! icosanoid catabolic process created_by: rl creation_date: 2016-07-31T08:20:02Z [Term] id: GO:1905345 name: protein localization to cleavage furrow namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow." [GO_REF:0000087, GOC:TermGenie, PMID:27082518] synonym: "protein localisation in cleavage furrow" EXACT [GOC:TermGenie] synonym: "protein localisation to cleavage furrow" EXACT [GOC:TermGenie] synonym: "protein localization in cleavage furrow" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072741 ! protein localization to cell division site is_a: GO:1990778 ! protein localization to cell periphery created_by: mah creation_date: 2016-08-01T13:20:05Z [Term] id: GO:1905346 name: protein localization to cleavage furrow rim namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow rim." [GO_REF:0000087, GOC:TermGenie, PMID:27082518] synonym: "protein localisation in cleavage furrow rim" EXACT [GOC:TermGenie] synonym: "protein localisation to cleavage furrow rim" EXACT [GOC:TermGenie] synonym: "protein localization in cleavage furrow rim" EXACT [GOC:TermGenie] is_a: GO:1905345 ! protein localization to cleavage furrow created_by: mah creation_date: 2016-08-01T13:20:13Z [Term] id: GO:1905347 name: endodeoxyribonuclease complex namespace: cellular_component def: "A protein complex which is capable of endodeoxyribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719] comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay). synonym: "Mus81-Eme1 complex" NARROW [] synonym: "Mus81-Eme2 complex" NARROW [] is_a: GO:1905348 ! endonuclease complex created_by: bhm creation_date: 2016-08-03T12:20:12Z [Term] id: GO:1905348 name: endonuclease complex namespace: cellular_component def: "A protein complex which is capable of endonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719] comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay). is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2016-08-03T12:27:00Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0060271 ! cilium assembly created_by: pr creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905350 name: Y-shaped link assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:23728985, PMID:24664739, PMID:26595381, PMID:4554367] synonym: "membrane-microtubule complex assembly" RELATED [GOC:TermGenie] synonym: "membrane-microtubule complex formation" RELATED [GOC:TermGenie] synonym: "Y-link assembly" RELATED [GOC:TermGenie] synonym: "Y-link formation" RELATED [GOC:TermGenie] synonym: "Y-link structure assembly" RELATED [GOC:TermGenie] synonym: "Y-link structure formation" RELATED [GOC:TermGenie] synonym: "Y-shaped assemblage assembly" RELATED [GOC:TermGenie] synonym: "Y-shaped assemblage formation" RELATED [GOC:TermGenie] synonym: "Y-shaped fiber assembly" RELATED [GOC:TermGenie] synonym: "Y-shaped fiber formation" RELATED [GOC:TermGenie] synonym: "Y-shaped fibre assembly" RELATED [GOC:TermGenie] synonym: "Y-shaped fibre formation" RELATED [GOC:TermGenie] synonym: "Y-shaped link formation" EXACT [GOC:TermGenie] synonym: "Y-shaped linker assembly" RELATED [GOC:TermGenie] synonym: "Y-shaped linker formation" RELATED [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: pr creation_date: 2016-08-04T16:04:26Z [Term] id: GO:1905351 name: pericyte cell migration namespace: biological_process def: "The orderly movement of a pericyte cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26268439] is_a: GO:0016477 ! cell migration created_by: rph creation_date: 2016-08-05T12:01:48Z [Term] id: GO:1905352 name: ciliary necklace assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary necklace." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:20399632, PMID:6409906] synonym: "cilial necklace assembly" EXACT [GOC:TermGenie] synonym: "cilial necklace formation" EXACT [GOC:TermGenie] synonym: "ciliary necklace formation" EXACT [GOC:TermGenie] synonym: "cilium necklace assembly" EXACT [GOC:TermGenie] synonym: "cilium necklace formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: pr creation_date: 2016-08-05T14:01:23Z [Term] id: GO:1905353 name: ciliary transition fiber assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:24189274] synonym: "centriolar distal appendage assembly" RELATED [GOC:TermGenie] synonym: "centriolar distal appendage formation" RELATED [GOC:TermGenie] synonym: "cilial transition fiber assembly" EXACT [GOC:TermGenie] synonym: "cilial transition fiber formation" EXACT [GOC:TermGenie] synonym: "cilial transition fibre assembly" EXACT [GOC:TermGenie] synonym: "cilial transition fibre formation" EXACT [GOC:TermGenie] synonym: "ciliary transition fiber formation" EXACT [GOC:TermGenie] synonym: "ciliary transition fibre assembly" EXACT [GOC:TermGenie] synonym: "ciliary transition fibre formation" EXACT [GOC:TermGenie] synonym: "cilium transition fiber assembly" EXACT [GOC:TermGenie] synonym: "cilium transition fiber formation" EXACT [GOC:TermGenie] synonym: "cilium transition fibre assembly" EXACT [GOC:TermGenie] synonym: "cilium transition fibre formation" EXACT [GOC:TermGenie] synonym: "distal appendage of basal body assembly" RELATED [GOC:TermGenie] synonym: "distal appendage of basal body formation" RELATED [GOC:TermGenie] synonym: "distal appendage of centriole assembly" RELATED [GOC:TermGenie] synonym: "distal appendage of centriole formation" RELATED [GOC:TermGenie] synonym: "distal appendage of mother centriole assembly" RELATED [GOC:TermGenie] synonym: "distal appendage of mother centriole formation" RELATED [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: pr creation_date: 2016-08-05T14:01:32Z [Term] id: GO:1905354 name: exoribonuclease complex namespace: cellular_component def: "A protein complex which is capable of exoribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896] comment: An example of this is DIS3 in human (Q9Y2L1) in PMID:17174896 (inferred from direct assay). is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-08-08T10:18:29Z [Term] id: GO:1905355 name: spine apparatus assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a spine apparatus." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12928494] synonym: "dense material assembly" NARROW [GOC:TermGenie] synonym: "dense material formation" NARROW [GOC:TermGenie] synonym: "spine apparatus formation" EXACT [GOC:TermGenie] is_a: GO:0070925 ! organelle assembly created_by: bf creation_date: 2016-08-09T10:12:29Z [Term] id: GO:1905356 name: regulation of snRNA pseudouridine synthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031120 ! snRNA pseudouridine synthesis relationship: regulates GO:0031120 ! snRNA pseudouridine synthesis created_by: se creation_date: 2016-08-09T19:12:27Z [Term] id: GO:1905357 name: negative regulation of snRNA pseudouridine synthesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] synonym: "down regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031120 ! snRNA pseudouridine synthesis relationship: negatively_regulates GO:0031120 ! snRNA pseudouridine synthesis created_by: se creation_date: 2016-08-09T19:12:35Z [Term] id: GO:1905358 name: positive regulation of snRNA pseudouridine synthesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] synonym: "activation of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie] synonym: "up regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031120 ! snRNA pseudouridine synthesis relationship: positively_regulates GO:0031120 ! snRNA pseudouridine synthesis created_by: se creation_date: 2016-08-09T19:12:42Z [Term] id: GO:1905359 name: protein localization to meiotic spindle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle." [GO_REF:0000087, GOC:TermGenie, PMID:26696398] synonym: "protein localisation to meiotic spindle" EXACT [GOC:TermGenie] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton created_by: mah creation_date: 2016-08-10T14:49:03Z [Term] id: GO:1905360 name: GTPase complex namespace: cellular_component def: "A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006] comment: An example of this is HRAS in human (P01112) in PMID:9178006 (inferred from direct assay). synonym: "HRAS-SOS1 complex" NARROW [] synonym: "RASH-SOS1 complex" NARROW [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-08-11T15:34:44Z [Term] id: GO:1905362 name: negative regulation of endosomal vesicle fusion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "down regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "downregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "downregulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "inhibition of endosomal vesicle fusion" NARROW [GOC:TermGenie] synonym: "inhibition of endosome vesicle fusion" NARROW [GOC:TermGenie] synonym: "negative regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:1905364 ! regulation of endosomal vesicle fusion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034058 ! endosomal vesicle fusion relationship: negatively_regulates GO:0034058 ! endosomal vesicle fusion created_by: bc creation_date: 2016-08-16T11:40:44Z [Term] id: GO:1905363 name: positive regulation of endosomal vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of endosomal vesicle fusion" NARROW [GOC:TermGenie] synonym: "activation of endosome vesicle fusion" NARROW [GOC:TermGenie] synonym: "positive regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "up regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "up regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] synonym: "upregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] synonym: "upregulation of endosome vesicle fusion" EXACT [GOC:TermGenie] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:1905364 ! regulation of endosomal vesicle fusion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034058 ! endosomal vesicle fusion relationship: positively_regulates GO:0034058 ! endosomal vesicle fusion created_by: bc creation_date: 2016-08-16T11:40:51Z [Term] id: GO:1905364 name: regulation of endosomal vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] is_a: GO:0031338 ! regulation of vesicle fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034058 ! endosomal vesicle fusion relationship: regulates GO:0034058 ! endosomal vesicle fusion created_by: bc creation_date: 2016-08-16T11:40:36Z [Term] id: GO:1905365 name: regulation of intralumenal vesicle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of endosome membrane budding" EXACT [GOC:TermGenie] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1904978 ! regulation of endosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070676 ! intralumenal vesicle formation relationship: regulates GO:0070676 ! intralumenal vesicle formation created_by: bc creation_date: 2016-08-16T12:00:01Z [Term] id: GO:1905366 name: negative regulation of intralumenal vesicle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "down regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "down-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] synonym: "downregulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "downregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] synonym: "inhibition of endosome membrane budding" NARROW [GOC:TermGenie] synonym: "inhibition of intralumenal vesicle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of endosome membrane budding" EXACT [GOC:TermGenie] is_a: GO:0051051 ! negative regulation of transport is_a: GO:1904979 ! negative regulation of endosome organization is_a: GO:1905365 ! regulation of intralumenal vesicle formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070676 ! intralumenal vesicle formation relationship: negatively_regulates GO:0070676 ! intralumenal vesicle formation created_by: bc creation_date: 2016-08-16T12:00:09Z [Term] id: GO:1905367 name: positive regulation of intralumenal vesicle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of endosome membrane budding" NARROW [GOC:TermGenie] synonym: "activation of intralumenal vesicle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "up regulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "up regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "up-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] synonym: "upregulation of endosome membrane budding" EXACT [GOC:TermGenie] synonym: "upregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] is_a: GO:0051050 ! positive regulation of transport is_a: GO:1904980 ! positive regulation of endosome organization is_a: GO:1905365 ! regulation of intralumenal vesicle formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070676 ! intralumenal vesicle formation relationship: positively_regulates GO:0070676 ! intralumenal vesicle formation created_by: bc creation_date: 2016-08-16T12:00:16Z [Term] id: GO:1905368 name: peptidase complex namespace: cellular_component def: "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). synonym: "protease complex" EXACT [] synonym: "tryptase complex" NARROW [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-08-16T12:49:36Z [Term] id: GO:1905369 name: endopeptidase complex namespace: cellular_component def: "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). is_a: GO:1905368 ! peptidase complex created_by: bhm creation_date: 2016-08-16T12:52:16Z [Term] id: GO:1905370 name: serine-type endopeptidase complex namespace: cellular_component def: "A protein complex which is capable of serine-type endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). is_a: GO:1905286 ! serine-type peptidase complex is_a: GO:1905369 ! endopeptidase complex created_by: bhm creation_date: 2016-08-16T13:09:57Z [Term] id: GO:1905371 name: ceramide phosphoethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] synonym: "ceramide phosphoethanolamine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process created_by: hjd creation_date: 2016-08-16T17:10:56Z [Term] id: GO:1905372 name: ceramide phosphoethanolamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] synonym: "ceramide phosphoethanolamine breakdown" EXACT [GOC:TermGenie] synonym: "ceramide phosphoethanolamine catabolism" EXACT [GOC:TermGenie] synonym: "ceramide phosphoethanolamine degradation" EXACT [GOC:TermGenie] is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process created_by: hjd creation_date: 2016-08-16T17:11:04Z [Term] id: GO:1905373 name: ceramide phosphoethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] synonym: "ceramide phosphoethanolamine anabolism" EXACT [GOC:TermGenie] synonym: "ceramide phosphoethanolamine biosynthesis" EXACT [GOC:TermGenie] synonym: "ceramide phosphoethanolamine formation" EXACT [GOC:TermGenie] synonym: "ceramide phosphoethanolamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process created_by: hjd creation_date: 2016-08-16T17:11:12Z [Term] id: GO:1905374 name: response to homocysteine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473] synonym: "response to 2-amino-4-mercaptobutyric acid" EXACT [] synonym: "response to 2-amino-4-sulfanylbutanoic acid" EXACT [] synonym: "response to Hcy" EXACT [] is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2016-08-17T20:17:53Z [Term] id: GO:1905375 name: cellular response to homocysteine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473] synonym: "cellular response to 2-amino-4-mercaptobutyric acid" EXACT [] synonym: "cellular response to 2-amino-4-sulfanylbutanoic acid" EXACT [] synonym: "cellular response to Hcy" EXACT [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1905374 ! response to homocysteine created_by: sl creation_date: 2016-08-17T20:18:00Z [Term] id: GO:1905376 name: negative regulation of cytochrome-c oxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26722473] synonym: "down regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "down regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "down regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "down regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "down regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "down regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "down regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "down regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "down regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "down-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "down-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "down-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "down-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "down-regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "down-regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "down-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "down-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "downregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "downregulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "downregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "downregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "downregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "downregulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "downregulation of indophenolase" NARROW [GOC:TermGenie] synonym: "downregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "downregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "inhibition of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "inhibition of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytochrome c oxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "inhibition of cytochrome-c oxidase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "inhibition of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of indophenolase" NARROW [GOC:TermGenie] synonym: "inhibition of NADH cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "inhibition of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] synonym: "negative regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] synonym: "negative regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] synonym: "negative regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] synonym: "negative regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] synonym: "negative regulation of indophenol oxidase" NARROW [GOC:TermGenie] synonym: "negative regulation of indophenolase" NARROW [GOC:TermGenie] synonym: "negative regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] synonym: "negative regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1904733 ! negative regulation of electron transfer activity is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004129 ! cytochrome-c oxidase activity relationship: negatively_regulates GO:0004129 ! cytochrome-c oxidase activity created_by: sl creation_date: 2016-08-17T20:29:57Z [Term] id: GO:1905377 name: response to D-galactose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574] synonym: "response to D-Gal" EXACT [] synonym: "response to D-galacto-hexose" EXACT [] is_a: GO:0009746 ! response to hexose created_by: sl creation_date: 2016-08-17T22:17:25Z [Term] id: GO:1905378 name: cellular response to D-galactose namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574] synonym: "cellular response to D-Gal" EXACT [] synonym: "cellular response to D-galacto-hexose" EXACT [] is_a: GO:0071331 ! cellular response to hexose stimulus is_a: GO:1905377 ! response to D-galactose created_by: sl creation_date: 2016-08-17T22:17:32Z [Term] id: GO:1905379 name: beta-N-acetylhexosaminidase complex namespace: cellular_component def: "A protein complex which is capable of beta-N-acetylhexosaminidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:6458607] comment: An example of this is HEXB in human (UniProt symbol P07686) in PMID:6458607 (inferred from direct assay). synonym: "HEX A complex" NARROW [] synonym: "HEX B complex" NARROW [] synonym: "HEX S complex" NARROW [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2016-08-18T08:26:15Z [Term] id: GO:1905380 name: regulation of snRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] synonym: "regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042795 ! snRNA transcription by RNA polymerase II relationship: regulates GO:0042795 ! snRNA transcription by RNA polymerase II created_by: bhm creation_date: 2016-08-18T13:39:20Z [Term] id: GO:1905381 name: negative regulation of snRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] synonym: "down regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "down regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "down-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "downregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "downregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "inhibition of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie] synonym: "inhibition of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "negative regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II relationship: negatively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II created_by: bhm creation_date: 2016-08-18T13:39:27Z [Term] id: GO:1905382 name: positive regulation of snRNA transcription by RNA polymerase II namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] comment: An example of this is GTF2A1 in human (UniProt symbol P52655) in PMID:10022900 (inferred from direct assay). synonym: "activation of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie] synonym: "activation of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "positive regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "up-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] synonym: "upregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II relationship: positively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II created_by: bhm creation_date: 2016-08-18T13:39:34Z [Term] id: GO:1905383 name: protein localization to presynapse namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494] synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494] is_a: GO:0035418 ! protein localization to synapse created_by: dos creation_date: 2016-08-18T14:42:59Z [Term] id: GO:1905384 name: regulation of protein localization to presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905383 ! protein localization to presynapse relationship: regulates GO:1905383 ! protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:00Z [Term] id: GO:1905385 name: negative regulation of protein localization to presynapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905383 ! protein localization to presynapse relationship: negatively_regulates GO:1905383 ! protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:08Z [Term] id: GO:1905386 name: positive regulation of protein localization to presynapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902474 ! positive regulation of protein localization to synapse is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905383 ! protein localization to presynapse relationship: positively_regulates GO:1905383 ! protein localization to presynapse created_by: dos creation_date: 2016-08-18T14:56:21Z [Term] id: GO:1905387 name: response to beta-carotene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696] synonym: "response to beta,beta-carotene" EXACT [] is_a: GO:0033993 ! response to lipid created_by: sl creation_date: 2016-08-18T16:18:24Z [Term] id: GO:1905388 name: cellular response to beta-carotene namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696] synonym: "cellular response to beta,beta-carotene" EXACT [] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1905387 ! response to beta-carotene created_by: sl creation_date: 2016-08-18T16:18:31Z [Term] id: GO:1905389 name: response to leukotriene B4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734] synonym: "response to LTB4" EXACT [] is_a: GO:0070542 ! response to fatty acid created_by: sl creation_date: 2016-08-18T16:37:24Z [Term] id: GO:1905390 name: cellular response to leukotriene B4 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734] synonym: "cellular response to LTB4" EXACT [] is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:1905389 ! response to leukotriene B4 created_by: sl creation_date: 2016-08-18T16:37:31Z [Term] id: GO:1905391 name: regulation of protein localization to cell division site involved in cell separation after cytokinesis namespace: biological_process def: "Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334] synonym: "regulation of protein localisation to cell division site involved in cell separation after cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell division site involved in cell separation following cytokinesis" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell division site involved in cytokinetic cell separation" RELATED [GOC:TermGenie] synonym: "regulation of protein localisation to cell division site involved in mitotic cytokinetic cell separation" EXACT [GOC:TermGenie] is_a: GO:1901900 ! regulation of protein localization to cell division site intersection_of: GO:1901900 ! regulation of protein localization to cell division site intersection_of: part_of GO:0000920 ! septum digestion after cytokinesis relationship: part_of GO:0000920 ! septum digestion after cytokinesis created_by: vw creation_date: 2016-08-22T09:40:47Z [Term] id: GO:1905392 name: plant organ morphogenesis namespace: biological_process def: "The developmental process by which a plant organ is generated and organized." [GO_REF:0000083, GOC:tb, GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0099402 ! plant organ development created_by: tb creation_date: 2016-08-24T00:21:19Z [Term] id: GO:1905393 name: plant organ formation namespace: biological_process def: "The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:tb, GOC:TermGenie] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis created_by: tb creation_date: 2016-08-24T00:21:27Z [Term] id: GO:1905394 name: retromer complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a retromer complex." [GO_REF:000102, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586] is_a: GO:0044877 ! protein-containing complex binding created_by: bc creation_date: 2016-08-24T14:00:32Z [Term] id: GO:1905395 name: response to flavonoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2016-08-24T15:00:54Z [Term] id: GO:1905396 name: cellular response to flavonoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905395 ! response to flavonoid created_by: sl creation_date: 2016-08-24T15:01:02Z [Term] id: GO:1905397 name: activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any apoptotic process in an activated CD8-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] synonym: "activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process created_by: pga creation_date: 2016-08-25T08:09:27Z [Term] id: GO:1905398 name: activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any apoptotic process in an activated CD4-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] synonym: "activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070231 ! T cell apoptotic process created_by: pga creation_date: 2016-08-25T08:13:40Z [Term] id: GO:1905399 name: regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process relationship: regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:09:46Z [Term] id: GO:1905400 name: negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process relationship: negatively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:09:53Z [Term] id: GO:1905401 name: positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process relationship: positively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:10:00Z [Term] id: GO:1905402 name: regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process relationship: regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:13:56Z [Term] id: GO:1905403 name: negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070233 ! negative regulation of T cell apoptotic process is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process relationship: negatively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:14:03Z [Term] id: GO:1905404 name: positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] synonym: "activation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0070234 ! positive regulation of T cell apoptotic process is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process relationship: positively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process created_by: pga creation_date: 2016-08-25T09:14:10Z [Term] id: GO:1905405 name: regulation of mitotic cohesin loading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0071922 ! regulation of cohesin loading intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061780 ! mitotic cohesin loading relationship: regulates GO:0061780 ! mitotic cohesin loading created_by: vw creation_date: 2016-08-25T14:48:46Z [Term] id: GO:1905406 name: positive regulation of mitotic cohesin loading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation is_a: GO:1905309 ! positive regulation of cohesin loading is_a: GO:1905405 ! regulation of mitotic cohesin loading intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061780 ! mitotic cohesin loading relationship: positively_regulates GO:0061780 ! mitotic cohesin loading created_by: vw creation_date: 2016-08-25T14:49:01Z [Term] id: GO:1905407 name: regulation of creatine transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:1903959 ! regulation of anion transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005308 ! creatine transmembrane transporter activity relationship: regulates GO:0005308 ! creatine transmembrane transporter activity created_by: bc creation_date: 2016-08-25T15:08:48Z [Term] id: GO:1905408 name: negative regulation of creatine transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] synonym: "down regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "down-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "downregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "inhibition of creatine transmembrane transporter activity" NARROW [GOC:TermGenie] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity relationship: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity created_by: bc creation_date: 2016-08-25T15:08:56Z [Term] id: GO:1905409 name: positive regulation of creatine transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] synonym: "activation of creatine transmembrane transporter activity" NARROW [GOC:TermGenie] synonym: "up regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "up-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] synonym: "upregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005308 ! creatine transmembrane transporter activity relationship: positively_regulates GO:0005308 ! creatine transmembrane transporter activity created_by: bc creation_date: 2016-08-25T15:09:04Z [Term] id: GO:1905410 name: regulation of mitotic cohesin unloading namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:1905343 ! regulation of cohesin unloading intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061781 ! mitotic cohesin unloading relationship: regulates GO:0061781 ! mitotic cohesin unloading created_by: vw creation_date: 2016-08-25T15:45:22Z [Term] id: GO:1905411 name: positive regulation of mitotic cohesin unloading namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1905339 ! positive regulation of cohesin unloading is_a: GO:1905410 ! regulation of mitotic cohesin unloading intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061781 ! mitotic cohesin unloading relationship: positively_regulates GO:0061781 ! mitotic cohesin unloading created_by: vw creation_date: 2016-08-25T15:45:30Z [Term] id: GO:1905412 name: negative regulation of mitotic cohesin loading namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:0071923 ! negative regulation of cohesin loading is_a: GO:1905405 ! regulation of mitotic cohesin loading intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061780 ! mitotic cohesin loading relationship: negatively_regulates GO:0061780 ! mitotic cohesin loading created_by: vw creation_date: 2016-08-27T15:24:35Z [Term] id: GO:1905413 name: regulation of dense core granule exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] synonym: "regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: occurs_in GO:0098793 ! presynapse intersection_of: regulates GO:1990504 ! dense core granule exocytosis relationship: occurs_in GO:0098793 ! presynapse relationship: regulates GO:1990504 ! dense core granule exocytosis created_by: bf creation_date: 2016-08-31T08:02:21Z [Term] id: GO:1905414 name: negative regulation of dense core granule exocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of dense core granule exocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of dense core vesicle exocytosis" NARROW [GOC:TermGenie] synonym: "negative regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990504 ! dense core granule exocytosis relationship: negatively_regulates GO:1990504 ! dense core granule exocytosis created_by: bf creation_date: 2016-08-31T08:02:28Z [Term] id: GO:1905415 name: positive regulation of dense core granule exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] synonym: "activation of dense core granule exocytosis" NARROW [GOC:TermGenie] synonym: "activation of dense core vesicle exocytosis" NARROW [GOC:TermGenie] synonym: "positive regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990504 ! dense core granule exocytosis relationship: positively_regulates GO:1990504 ! dense core granule exocytosis created_by: bf creation_date: 2016-08-31T08:02:36Z [Term] id: GO:1905416 name: regulation of amoeboid sperm motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] is_a: GO:2000145 ! regulation of cell motility is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097723 ! amoeboid sperm motility relationship: regulates GO:0097723 ! amoeboid sperm motility created_by: pr creation_date: 2016-09-01T11:28:48Z [Term] id: GO:1905417 name: negative regulation of amoeboid sperm motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "down regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "down regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "down regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "down regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "down-regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "down-regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "down-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "down-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "downregulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "downregulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "downregulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "downregulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "inhibition of ameboid sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of ameboid sperm movement" NARROW [GOC:TermGenie] synonym: "inhibition of amoeboid sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of amoeboid sperm movement" NARROW [GOC:TermGenie] synonym: "negative regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "negative regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "negative regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] is_a: GO:1905416 ! regulation of amoeboid sperm motility is_a: GO:2000146 ! negative regulation of cell motility is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097723 ! amoeboid sperm motility relationship: negatively_regulates GO:0097723 ! amoeboid sperm motility created_by: pr creation_date: 2016-09-01T11:28:55Z [Term] id: GO:1905418 name: positive regulation of amoeboid sperm motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "activation of ameboid sperm motility" NARROW [GOC:TermGenie] synonym: "activation of ameboid sperm movement" NARROW [GOC:TermGenie] synonym: "activation of amoeboid sperm motility" NARROW [GOC:TermGenie] synonym: "activation of amoeboid sperm movement" NARROW [GOC:TermGenie] synonym: "positive regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "positive regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "positive regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "up regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "up regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "up regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "up regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "up-regulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "up-regulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "up-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "up-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] synonym: "upregulation of ameboid sperm motility" EXACT [GOC:TermGenie] synonym: "upregulation of ameboid sperm movement" EXACT [GOC:TermGenie] synonym: "upregulation of amoeboid sperm motility" EXACT [GOC:TermGenie] synonym: "upregulation of amoeboid sperm movement" EXACT [GOC:TermGenie] is_a: GO:1905416 ! regulation of amoeboid sperm motility is_a: GO:2000147 ! positive regulation of cell motility is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097723 ! amoeboid sperm motility relationship: positively_regulates GO:0097723 ! amoeboid sperm motility created_by: pr creation_date: 2016-09-01T11:29:03Z [Term] id: GO:1905419 name: sperm flagellum movement involved in flagellated sperm motility namespace: biological_process alt_id: GO:0097724 def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] is_a: GO:0022414 ! reproductive process is_a: GO:0060294 ! cilium movement involved in cell motility intersection_of: GO:0003341 ! cilium movement intersection_of: part_of GO:0030317 ! flagellated sperm motility relationship: part_of GO:0030317 ! flagellated sperm motility created_by: krc creation_date: 2016-09-01T17:52:39Z [Term] id: GO:1905420 name: vascular smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:0035886 ! vascular smooth muscle cell differentiation is_a: GO:0090679 ! cell differentiation involved in phenotypic switching intersection_of: GO:0035886 ! vascular smooth muscle cell differentiation intersection_of: part_of GO:0090677 ! reversible differentiation created_by: rph creation_date: 2016-09-05T12:43:46Z [Term] id: GO:1905421 name: regulation of plant organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905392 ! plant organ morphogenesis relationship: regulates GO:1905392 ! plant organ morphogenesis created_by: tb creation_date: 2016-09-06T23:00:14Z [Term] id: GO:1905422 name: negative regulation of plant organ morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] synonym: "down regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of plant organ morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of plant organ morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905421 ! regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905392 ! plant organ morphogenesis relationship: negatively_regulates GO:1905392 ! plant organ morphogenesis created_by: tb creation_date: 2016-09-06T23:00:22Z [Term] id: GO:1905423 name: positive regulation of plant organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] synonym: "activation of plant organ morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of plant organ morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905421 ! regulation of plant organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905392 ! plant organ morphogenesis relationship: positively_regulates GO:1905392 ! plant organ morphogenesis created_by: tb creation_date: 2016-09-06T23:00:29Z [Term] id: GO:1905424 name: regulation of Wnt-mediated midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647] synonym: "regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling" RELATED [GOC:bf] synonym: "regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation relationship: regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-09-07T10:03:36Z [Term] id: GO:1905425 name: negative regulation of Wnt-mediated midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "down regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "down-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "down-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "downregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "downregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "inhibition of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "inhibition of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of midbrain dopaminergic neuron differentiation by negative regulation of Wnt signaling" RELATED [GOC:bf] synonym: "negative regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "negative regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "negative regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:1904957 ! negative regulation of midbrain dopaminergic neuron differentiation is_a: GO:1905424 ! regulation of Wnt-mediated midbrain dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation relationship: negatively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-09-07T10:03:44Z [Term] id: GO:1905426 name: positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647] synonym: "activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] synonym: "activation of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] synonym: "activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "activation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "activation of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling" RELATED [GOC:bf] synonym: "positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "positive regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "up regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "up-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] synonym: "upregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:1904958 ! positive regulation of midbrain dopaminergic neuron differentiation is_a: GO:1905424 ! regulation of Wnt-mediated midbrain dopaminergic neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation relationship: positively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation created_by: bf creation_date: 2016-09-07T10:03:51Z [Term] id: GO:1905427 name: intracellular signal transduction involved in positive regulation of cell growth namespace: biological_process def: "Any intracellular signal transduction that is involved in positive regulation of cell growth." [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811] synonym: "intracellular protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signal transduction pathway involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling chain involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in positive regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "intracellular signaling chain involved in up regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in up-regulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling chain involved in upregulation of cell growth" EXACT [GOC:TermGenie] synonym: "intracellular signaling pathway involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "intracellular signaling pathway involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in activation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] synonym: "signal transmission via intracellular cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0035556 ! intracellular signal transduction intersection_of: part_of GO:0030307 ! positive regulation of cell growth relationship: part_of GO:0030307 ! positive regulation of cell growth created_by: dph creation_date: 2016-09-07T18:15:01Z [Term] id: GO:1905428 name: regulation of plant organ formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plant organ formation." [GO_REF:0000058, GOC:tb, GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905393 ! plant organ formation relationship: regulates GO:1905393 ! plant organ formation created_by: tb creation_date: 2016-09-07T18:57:47Z [Term] id: GO:1905429 name: response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "response to aminoacetic acid" EXACT [] synonym: "response to aminoethanoic acid" EXACT [] synonym: "response to Gly" EXACT [] synonym: "response to glycin" EXACT [] is_a: GO:0007584 ! response to nutrient is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2016-09-08T22:09:15Z [Term] id: GO:1905430 name: cellular response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "cellular response to aminoacetic acid" EXACT [] synonym: "cellular response to aminoethanoic acid" EXACT [] synonym: "cellular response to Gly" EXACT [] synonym: "cellular response to glycin" EXACT [] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1905429 ! response to glycine created_by: sl creation_date: 2016-09-08T22:09:23Z [Term] id: GO:1905431 name: microcystin transport namespace: biological_process def: "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26055554] is_a: GO:0015833 ! peptide transport is_a: GO:1901998 ! toxin transport created_by: cvs creation_date: 2016-09-13T23:15:51Z [Term] id: GO:1905432 name: regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide relationship: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:56:47Z [Term] id: GO:1905433 name: negative regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide relationship: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:56:55Z [Term] id: GO:1905434 name: positive regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide relationship: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide created_by: bf creation_date: 2016-09-14T10:57:02Z [Term] id: GO:1905435 name: regulation of histone H3-K4 trimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] is_a: GO:0051569 ! regulation of histone H3-K4 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080182 ! histone H3-K4 trimethylation relationship: regulates GO:0080182 ! histone H3-K4 trimethylation created_by: hbye creation_date: 2016-09-14T13:08:55Z [Term] id: GO:1905436 name: negative regulation of histone H3-K4 trimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] synonym: "down regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3-K4 trimethylation" NARROW [GOC:TermGenie] is_a: GO:0051572 ! negative regulation of histone H3-K4 methylation is_a: GO:1905435 ! regulation of histone H3-K4 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0080182 ! histone H3-K4 trimethylation relationship: negatively_regulates GO:0080182 ! histone H3-K4 trimethylation created_by: hbye creation_date: 2016-09-14T13:09:03Z [Term] id: GO:1905437 name: positive regulation of histone H3-K4 trimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] synonym: "activation of histone H3-K4 trimethylation" NARROW [GOC:TermGenie] synonym: "up regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] is_a: GO:0051571 ! positive regulation of histone H3-K4 methylation is_a: GO:1905435 ! regulation of histone H3-K4 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0080182 ! histone H3-K4 trimethylation relationship: positively_regulates GO:0080182 ! histone H3-K4 trimethylation created_by: hbye creation_date: 2016-09-14T13:09:11Z [Term] id: GO:1905438 name: non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation namespace: biological_process def: "Any non-canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] is_a: GO:0035567 ! non-canonical Wnt signaling pathway is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation intersection_of: GO:0035567 ! non-canonical Wnt signaling pathway intersection_of: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation created_by: bc creation_date: 2016-09-14T15:52:22Z [Term] id: GO:1905439 name: response to chondroitin 6'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: cvs creation_date: 2016-09-14T18:56:12Z [Term] id: GO:1905440 name: cellular response to chondroitin 6'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905439 ! response to chondroitin 6'-sulfate created_by: cvs creation_date: 2016-09-14T18:56:19Z [Term] id: GO:1905441 name: response to chondroitin 4'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: cvs creation_date: 2016-09-14T18:56:27Z [Term] id: GO:1905442 name: cellular response to chondroitin 4'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905441 ! response to chondroitin 4'-sulfate created_by: cvs creation_date: 2016-09-14T18:56:34Z [Term] id: GO:1905443 name: regulation of clathrin coat assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940] synonym: "regulation of clathrin cage assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048268 ! clathrin coat assembly relationship: regulates GO:0048268 ! clathrin coat assembly created_by: bf creation_date: 2016-09-15T14:38:22Z [Term] id: GO:1905444 name: negative regulation of clathrin coat assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "down regulation of clathrin coat assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin coat assembly" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin coat assembly" EXACT [GOC:TermGenie] synonym: "inhibition of clathrin cage assembly" NARROW [GOC:TermGenie] synonym: "inhibition of clathrin coat assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of clathrin cage assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905443 ! regulation of clathrin coat assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048268 ! clathrin coat assembly relationship: negatively_regulates GO:0048268 ! clathrin coat assembly created_by: bf creation_date: 2016-09-15T14:38:30Z [Term] id: GO:1905445 name: positive regulation of clathrin coat assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940] synonym: "activation of clathrin cage assembly" NARROW [GOC:TermGenie] synonym: "activation of clathrin coat assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "up regulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "up regulation of clathrin coat assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of clathrin coat assembly" EXACT [GOC:TermGenie] synonym: "upregulation of clathrin cage assembly" EXACT [GOC:TermGenie] synonym: "upregulation of clathrin coat assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905443 ! regulation of clathrin coat assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048268 ! clathrin coat assembly relationship: positively_regulates GO:0048268 ! clathrin coat assembly created_by: bf creation_date: 2016-09-15T14:38:38Z [Term] id: GO:1905446 name: regulation of mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] synonym: "regulation of mitochondrial electron transport" BROAD [GOC:TermGenie] synonym: "regulation of organelle ATP synthesis coupled electron transport" BROAD [GOC:TermGenie] is_a: GO:0002082 ! regulation of oxidative phosphorylation is_a: GO:0043457 ! regulation of cellular respiration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport relationship: regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport created_by: dph creation_date: 2016-09-15T18:57:58Z [Term] id: GO:1905447 name: negative regulation of mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] synonym: "down regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie] is_a: GO:0090324 ! negative regulation of oxidative phosphorylation is_a: GO:1901856 ! negative regulation of cellular respiration is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport relationship: negatively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport created_by: dph creation_date: 2016-09-15T18:58:06Z [Term] id: GO:1905448 name: positive regulation of mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] synonym: "activation of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie] synonym: "up regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] is_a: GO:1901857 ! positive regulation of cellular respiration is_a: GO:1903862 ! positive regulation of oxidative phosphorylation is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport relationship: positively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport created_by: dph creation_date: 2016-09-15T18:58:14Z [Term] id: GO:1905449 name: regulation of Fc-gamma receptor signaling pathway involved in phagocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] synonym: "regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0050764 ! regulation of phagocytosis is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis relationship: regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis created_by: sl creation_date: 2016-09-15T19:41:50Z [Term] id: GO:1905450 name: negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] synonym: "down regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "down regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "down-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "downregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "inhibition of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie] synonym: "inhibition of IgG-mediated phagocytosis" NARROW [GOC:TermGenie] synonym: "negative regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "negative regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "negative regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis relationship: negatively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis created_by: sl creation_date: 2016-09-15T19:41:58Z [Term] id: GO:1905451 name: positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] synonym: "activation of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie] synonym: "activation of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie] synonym: "activation of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie] synonym: "activation of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie] synonym: "activation of IgG-mediated phagocytosis" NARROW [GOC:TermGenie] synonym: "positive regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "positive regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "up regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "up-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] synonym: "upregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:0060369 ! positive regulation of Fc receptor mediated stimulatory signaling pathway is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis relationship: positively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis created_by: sl creation_date: 2016-09-15T19:42:06Z [Term] id: GO:1905452 name: obsolete canonical Wnt signaling pathway involved in regulation of stem cell proliferation namespace: biological_process def: "OBSOLETE. Any canonical Wnt signaling pathway that is involved in regulation of stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "canonical Wnt receptor signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in regulation of stem cell proliferation" NARROW [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] is_obsolete: true created_by: bc creation_date: 2016-09-16T11:52:42Z [Term] id: GO:1905453 name: regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002318 ! myeloid progenitor cell differentiation relationship: regulates GO:0002318 ! myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:18Z [Term] id: GO:1905454 name: negative regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation relationship: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:26Z [Term] id: GO:1905455 name: positive regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation relationship: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:33Z [Term] id: GO:1905456 name: regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002320 ! lymphoid progenitor cell differentiation relationship: regulates GO:0002320 ! lymphoid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:40Z [Term] id: GO:1905457 name: negative regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation relationship: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:48Z [Term] id: GO:1905458 name: positive regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation relationship: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation created_by: rz creation_date: 2016-09-16T12:32:55Z [Term] id: GO:1905459 name: regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process relationship: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process created_by: rph creation_date: 2016-09-19T11:33:54Z [Term] id: GO:1905460 name: negative regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process relationship: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process created_by: rph creation_date: 2016-09-19T11:34:03Z [Term] id: GO:1905461 name: positive regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process relationship: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process created_by: rph creation_date: 2016-09-19T11:34:10Z [Term] id: GO:1905462 name: regulation of DNA duplex unwinding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] synonym: "regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "regulation of duplex DNA melting" EXACT [GOC:TermGenie] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032508 ! DNA duplex unwinding relationship: regulates GO:0032508 ! DNA duplex unwinding created_by: ans creation_date: 2016-09-19T11:58:41Z [Term] id: GO:1905463 name: negative regulation of DNA duplex unwinding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] synonym: "down regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "down regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "down regulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "down-regulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "downregulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "downregulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "downregulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "inhibition of DNA duplex unwinding" NARROW [GOC:TermGenie] synonym: "inhibition of DNA unwinding" NARROW [GOC:TermGenie] synonym: "inhibition of duplex DNA melting" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "negative regulation of duplex DNA melting" EXACT [GOC:TermGenie] is_a: GO:1905462 ! regulation of DNA duplex unwinding is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032508 ! DNA duplex unwinding relationship: negatively_regulates GO:0032508 ! DNA duplex unwinding created_by: ans creation_date: 2016-09-19T11:58:48Z [Term] id: GO:1905464 name: positive regulation of DNA duplex unwinding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] synonym: "activation of DNA duplex unwinding" NARROW [GOC:TermGenie] synonym: "activation of DNA unwinding" NARROW [GOC:TermGenie] synonym: "activation of duplex DNA melting" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "positive regulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "up regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "up regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "up regulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "up-regulation of duplex DNA melting" EXACT [GOC:TermGenie] synonym: "upregulation of DNA duplex unwinding" EXACT [GOC:TermGenie] synonym: "upregulation of DNA unwinding" EXACT [GOC:TermGenie] synonym: "upregulation of duplex DNA melting" EXACT [GOC:TermGenie] is_a: GO:1905462 ! regulation of DNA duplex unwinding is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032508 ! DNA duplex unwinding relationship: positively_regulates GO:0032508 ! DNA duplex unwinding created_by: ans creation_date: 2016-09-19T11:58:55Z [Term] id: GO:1905465 name: regulation of G-quadruplex DNA unwinding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044806 ! G-quadruplex DNA unwinding relationship: regulates GO:0044806 ! G-quadruplex DNA unwinding created_by: ans creation_date: 2016-09-19T12:15:45Z [Term] id: GO:1905466 name: negative regulation of G-quadruplex DNA unwinding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] synonym: "down regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] synonym: "down-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] synonym: "downregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] synonym: "inhibition of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie] is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044806 ! G-quadruplex DNA unwinding relationship: negatively_regulates GO:0044806 ! G-quadruplex DNA unwinding created_by: ans creation_date: 2016-09-19T12:15:53Z [Term] id: GO:1905467 name: positive regulation of G-quadruplex DNA unwinding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PubMed:26503245] synonym: "activation of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie] synonym: "up regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] synonym: "up-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] synonym: "upregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044806 ! G-quadruplex DNA unwinding relationship: positively_regulates GO:0044806 ! G-quadruplex DNA unwinding created_by: ans creation_date: 2016-09-19T12:16:01Z [Term] id: GO:1905468 name: regulation of clathrin-coated pit assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "regulation of coated pit formation" EXACT [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905224 ! clathrin-coated pit assembly relationship: regulates GO:1905224 ! clathrin-coated pit assembly created_by: bf creation_date: 2016-09-20T10:04:37Z [Term] id: GO:1905469 name: negative regulation of clathrin-coated pit assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "down regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "down regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "down regulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "down-regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "downregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "downregulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "downregulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "inhibition of clathrin-coated pit assembly" NARROW [GOC:TermGenie] synonym: "inhibition of clathrin-coated pit formation" NARROW [GOC:TermGenie] synonym: "inhibition of coated pit assembly" NARROW [GOC:TermGenie] synonym: "inhibition of coated pit formation" NARROW [GOC:TermGenie] synonym: "negative regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "negative regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of coated pit formation" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905468 ! regulation of clathrin-coated pit assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905224 ! clathrin-coated pit assembly relationship: negatively_regulates GO:1905224 ! clathrin-coated pit assembly created_by: bf creation_date: 2016-09-20T10:04:45Z [Term] id: GO:1905470 name: positive regulation of clathrin-coated pit assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of clathrin-coated pit assembly" NARROW [GOC:TermGenie] synonym: "activation of clathrin-coated pit formation" NARROW [GOC:TermGenie] synonym: "activation of coated pit assembly" NARROW [GOC:TermGenie] synonym: "activation of coated pit formation" NARROW [GOC:TermGenie] synonym: "positive regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "positive regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "up regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "up regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "up regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "up regulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "up-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "up-regulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of coated pit formation" EXACT [GOC:TermGenie] synonym: "upregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] synonym: "upregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] synonym: "upregulation of coated pit assembly" EXACT [GOC:TermGenie] synonym: "upregulation of coated pit formation" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905468 ! regulation of clathrin-coated pit assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905224 ! clathrin-coated pit assembly relationship: positively_regulates GO:1905224 ! clathrin-coated pit assembly created_by: bf creation_date: 2016-09-20T10:04:53Z [Term] id: GO:1905471 name: regulation of histone H3-K79 dimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] synonym: "regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] is_a: GO:2001160 ! regulation of histone H3-K79 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097725 ! histone H3-K79 dimethylation relationship: regulates GO:0097725 ! histone H3-K79 dimethylation created_by: hbye creation_date: 2016-09-21T15:27:02Z [Term] id: GO:1905472 name: negative regulation of histone H3-K79 dimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] synonym: "down regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "down regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "down-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "downregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "inhibition of histone H3 K79 dimethylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone H3-K79 dimethylation" NARROW [GOC:TermGenie] synonym: "inhibition of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie] synonym: "negative regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "negative regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] is_a: GO:1905471 ! regulation of histone H3-K79 dimethylation is_a: GO:2001161 ! negative regulation of histone H3-K79 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097725 ! histone H3-K79 dimethylation relationship: negatively_regulates GO:0097725 ! histone H3-K79 dimethylation created_by: hbye creation_date: 2016-09-21T15:27:10Z [Term] id: GO:1905473 name: positive regulation of histone H3-K79 dimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] synonym: "activation of histone H3 K79 dimethylation" NARROW [GOC:TermGenie] synonym: "activation of histone H3-K79 dimethylation" NARROW [GOC:TermGenie] synonym: "activation of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie] synonym: "positive regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "positive regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "up-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] synonym: "upregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] is_a: GO:1905471 ! regulation of histone H3-K79 dimethylation is_a: GO:2001162 ! positive regulation of histone H3-K79 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097725 ! histone H3-K79 dimethylation relationship: positively_regulates GO:0097725 ! histone H3-K79 dimethylation created_by: hbye creation_date: 2016-09-21T15:27:17Z [Term] id: GO:1905474 name: canonical Wnt signaling pathway involved in stem cell proliferation namespace: biological_process def: "Any canonical Wnt signaling pathway that is involved in stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] synonym: "canonical Wnt receptor signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie] synonym: "canonical Wnt-activated signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie] synonym: "frizzled-1 receptor signaling pathway involved in stem cell proliferation" NARROW [GOC:TermGenie] synonym: "Wnt receptor signaling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signaling pathway via beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] synonym: "Wnt receptor signalling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation intersection_of: GO:0060070 ! canonical Wnt signaling pathway intersection_of: part_of GO:0072089 ! stem cell proliferation relationship: part_of GO:0072089 ! stem cell proliferation created_by: bc creation_date: 2016-09-21T15:59:53Z [Term] id: GO:1905475 name: regulation of protein localization to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072657 ! protein localization to membrane relationship: regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:03Z [Term] id: GO:1905476 name: negative regulation of protein localization to membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072657 ! protein localization to membrane relationship: negatively_regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:10Z [Term] id: GO:1905477 name: positive regulation of protein localization to membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072657 ! protein localization to membrane relationship: positively_regulates GO:0072657 ! protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:18Z [Term] id: GO:1905478 name: regulation of glutamate-ammonia ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] synonym: "regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004356 ! glutamate-ammonia ligase activity relationship: regulates GO:0004356 ! glutamate-ammonia ligase activity created_by: pga creation_date: 2016-09-22T09:58:34Z [Term] id: GO:1905479 name: negative regulation of glutamate-ammonia ligase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] synonym: "down regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glutamine synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamine synthetase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "negative regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:1905478 ! regulation of glutamate-ammonia ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004356 ! glutamate-ammonia ligase activity relationship: negatively_regulates GO:0004356 ! glutamate-ammonia ligase activity created_by: pga creation_date: 2016-09-22T09:58:42Z [Term] id: GO:1905480 name: positive regulation of glutamate-ammonia ligase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] synonym: "activation of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie] synonym: "activation of glutamine synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie] synonym: "activation of L-glutamine synthetase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "positive regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glutamine synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:1905478 ! regulation of glutamate-ammonia ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004356 ! glutamate-ammonia ligase activity relationship: positively_regulates GO:0004356 ! glutamate-ammonia ligase activity created_by: pga creation_date: 2016-09-22T09:58:50Z [Term] id: GO:1905481 name: obsolete cytoplasmic sequestering of protein involved in mitotic DNA replication checkpoint namespace: biological_process def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic DNA replication checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: vw creation_date: 2016-09-22T18:20:35Z [Term] id: GO:1905482 name: obsolete cytoplasmic sequestering of protein involved in G2 DNA damage checkpoint namespace: biological_process def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: vw creation_date: 2016-09-22T18:23:55Z [Term] id: GO:1905483 name: regulation of motor neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097475 ! motor neuron migration relationship: regulates GO:0097475 ! motor neuron migration created_by: hbye creation_date: 2016-09-23T12:49:54Z [Term] id: GO:1905484 name: negative regulation of motor neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001223 ! negative regulation of neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097475 ! motor neuron migration relationship: negatively_regulates GO:0097475 ! motor neuron migration created_by: hbye creation_date: 2016-09-23T12:50:11Z [Term] id: GO:1905485 name: positive regulation of motor neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie] synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001224 ! positive regulation of neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097475 ! motor neuron migration relationship: positively_regulates GO:0097475 ! motor neuron migration created_by: hbye creation_date: 2016-09-23T12:50:19Z [Term] id: GO:1905486 name: regulation of anterior/posterior axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033564 ! anterior/posterior axon guidance relationship: regulates GO:0033564 ! anterior/posterior axon guidance created_by: hbye creation_date: 2016-09-23T13:18:33Z [Term] id: GO:1905487 name: negative regulation of anterior/posterior axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "down regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "down-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "downregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "inhibition of anterior-posterior axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of anterior/posterior axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie] synonym: "negative regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "negative regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902668 ! negative regulation of axon guidance is_a: GO:1905486 ! regulation of anterior/posterior axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033564 ! anterior/posterior axon guidance relationship: negatively_regulates GO:0033564 ! anterior/posterior axon guidance created_by: hbye creation_date: 2016-09-23T13:18:41Z [Term] id: GO:1905488 name: positive regulation of anterior/posterior axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of anterior-posterior axon guidance" NARROW [GOC:TermGenie] synonym: "activation of anterior/posterior axon guidance" NARROW [GOC:TermGenie] synonym: "activation of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie] synonym: "positive regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "positive regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902669 ! positive regulation of axon guidance is_a: GO:1905486 ! regulation of anterior/posterior axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033564 ! anterior/posterior axon guidance relationship: positively_regulates GO:0033564 ! anterior/posterior axon guidance created_by: hbye creation_date: 2016-09-23T13:18:48Z [Term] id: GO:1905489 name: regulation of sensory neuron axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097374 ! sensory neuron axon guidance relationship: regulates GO:0097374 ! sensory neuron axon guidance created_by: hbye creation_date: 2016-09-23T13:18:56Z [Term] id: GO:1905490 name: negative regulation of sensory neuron axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "down regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] synonym: "inhibition of sensory neuron axon guidance" NARROW [GOC:TermGenie] is_a: GO:1902668 ! negative regulation of axon guidance is_a: GO:1905489 ! regulation of sensory neuron axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097374 ! sensory neuron axon guidance relationship: negatively_regulates GO:0097374 ! sensory neuron axon guidance created_by: hbye creation_date: 2016-09-23T13:19:04Z [Term] id: GO:1905491 name: positive regulation of sensory neuron axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of sensory neuron axon guidance" NARROW [GOC:TermGenie] synonym: "up regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] is_a: GO:1902669 ! positive regulation of axon guidance is_a: GO:1905489 ! regulation of sensory neuron axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097374 ! sensory neuron axon guidance relationship: positively_regulates GO:0097374 ! sensory neuron axon guidance created_by: hbye creation_date: 2016-09-23T13:19:12Z [Term] id: GO:1905492 name: positive regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie] synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048755 ! branching morphogenesis of a nerve relationship: positively_regulates GO:0048755 ! branching morphogenesis of a nerve created_by: hbye creation_date: 2016-09-23T14:11:52Z [Term] id: GO:1905493 name: regulation of G-quadruplex DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] synonym: "regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "regulation of G quartet binding" BROAD [GOC:TermGenie] synonym: "regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "regulation of G-quartet binding" BROAD [GOC:TermGenie] synonym: "regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051880 ! G-quadruplex DNA binding relationship: regulates GO:0051880 ! G-quadruplex DNA binding created_by: ans creation_date: 2016-09-26T14:53:21Z [Term] id: GO:1905494 name: negative regulation of G-quadruplex DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] synonym: "down regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of G quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of G quartet DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of G-DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of G-quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of G-quartet DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "inhibition of tetraplex DNA binding" NARROW [GOC:TermGenie] synonym: "negative regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "negative regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:1905493 ! regulation of G-quadruplex DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051880 ! G-quadruplex DNA binding relationship: negatively_regulates GO:0051880 ! G-quadruplex DNA binding created_by: ans creation_date: 2016-09-26T14:53:29Z [Term] id: GO:1905495 name: positive regulation of G-quadruplex DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] synonym: "activation of G quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "activation of G quartet DNA binding" NARROW [GOC:TermGenie] synonym: "activation of G-DNA binding" NARROW [GOC:TermGenie] synonym: "activation of G-quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "activation of G-quartet DNA binding" NARROW [GOC:TermGenie] synonym: "activation of quadruplex DNA binding" NARROW [GOC:TermGenie] synonym: "activation of tetraplex DNA binding" NARROW [GOC:TermGenie] synonym: "positive regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "positive regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "positive regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "positive regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "positive regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "positive regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of G quartet DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of G-DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of G-quartet DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of quadruplex DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of tetraplex DNA binding" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:1905493 ! regulation of G-quadruplex DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051880 ! G-quadruplex DNA binding relationship: positively_regulates GO:0051880 ! G-quadruplex DNA binding created_by: ans creation_date: 2016-09-26T14:53:37Z [Term] id: GO:1905496 name: regulation of triplex DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045142 ! triplex DNA binding relationship: regulates GO:0045142 ! triplex DNA binding created_by: ans creation_date: 2016-09-26T14:57:09Z [Term] id: GO:1905497 name: negative regulation of triplex DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] synonym: "down regulation of triplex DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of triplex DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of triplex DNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of triplex DNA binding" NARROW [GOC:TermGenie] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:1905496 ! regulation of triplex DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045142 ! triplex DNA binding relationship: negatively_regulates GO:0045142 ! triplex DNA binding created_by: ans creation_date: 2016-09-26T14:57:17Z [Term] id: GO:1905498 name: positive regulation of triplex DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PubMed:26503245] synonym: "activation of triplex DNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of triplex DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of triplex DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of triplex DNA binding" EXACT [GOC:TermGenie] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:1905496 ! regulation of triplex DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045142 ! triplex DNA binding relationship: positively_regulates GO:0045142 ! triplex DNA binding created_by: ans creation_date: 2016-09-26T14:57:25Z [Term] id: GO:1905499 name: trichome papilla formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a trichome papilla." [GO_REF:0000079, GOC:tb, GOC:TermGenie, PMID:24014871] synonym: "trichome papilla assembly" RELATED [] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0010090 ! trichome morphogenesis created_by: tb creation_date: 2016-09-27T00:28:06Z [Term] id: GO:1905500 name: obsolete heteroreceptor complex assembly namespace: biological_process def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a heteroreceptor complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "heteroreceptor complex formation" EXACT [GOC:TermGenie] is_obsolete: true created_by: pad creation_date: 2016-09-27T10:49:56Z [Term] id: GO:1905501 name: obsolete heteroreceptor complex disassembly namespace: biological_process def: "OBSOLETE. The disaggregation of a heteroreceptor complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: pad creation_date: 2016-09-27T10:50:04Z [Term] id: GO:1905502 name: acetyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acetyl-CoA." [GO_REF:0000067, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:24927529] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding is_a: GO:1901681 ! sulfur compound binding created_by: bc creation_date: 2016-09-27T16:33:44Z [Term] id: GO:1905503 name: regulation of motile cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilium assembly" RELATED [] synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902017 ! regulation of cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044458 ! motile cilium assembly relationship: regulates GO:0044458 ! motile cilium assembly created_by: krc creation_date: 2016-09-27T18:27:47Z [Term] id: GO:1905504 name: negative regulation of motile cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilium assembly" RELATED [] synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902018 ! negative regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044458 ! motile cilium assembly relationship: negatively_regulates GO:0044458 ! motile cilium assembly created_by: krc creation_date: 2016-09-27T18:27:55Z [Term] id: GO:1905505 name: positive regulation of motile cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilium assembly" RELATED [] synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0045724 ! positive regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044458 ! motile cilium assembly relationship: positively_regulates GO:0044458 ! motile cilium assembly created_by: krc creation_date: 2016-09-27T18:28:03Z [Term] id: GO:1905506 name: gerontoplast stroma namespace: cellular_component def: "Any plastid stroma that is part of a gerontoplast." [GO_REF:0000064, GOC:mag, GOC:TermGenie, PMID:11212360] is_a: GO:0009532 ! plastid stroma intersection_of: GO:0009532 ! plastid stroma intersection_of: part_of GO:0034400 ! gerontoplast relationship: part_of GO:0034400 ! gerontoplast created_by: tb creation_date: 2016-09-27T20:01:34Z [Term] id: GO:1905507 name: obsolete cytoplasmic sequestering of protein involved in mitotic G2 DNA damage checkpoint namespace: biological_process def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: vw creation_date: 2016-09-28T12:20:28Z [Term] id: GO:1905508 name: protein localization to microtubule organizing center namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] synonym: "protein localisation in microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localisation to microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localization in microtubule organizing center" EXACT [GOC:TermGenie] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton created_by: mah creation_date: 2016-09-28T12:32:16Z [Term] id: GO:1905509 name: protein localization to interphase microtubule organizing center namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an interphase microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] synonym: "protein localisation in interphase microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localisation to interphase microtubule organizing center" EXACT [GOC:TermGenie] synonym: "protein localization in interphase microtubule organizing center" EXACT [GOC:TermGenie] is_a: GO:1905508 ! protein localization to microtubule organizing center created_by: mah creation_date: 2016-09-28T12:32:24Z [Term] id: GO:1905510 name: negative regulation of myosin II filament assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416] comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules synonym: "down regulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "down regulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "down-regulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "downregulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "downregulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "inhibition of myosin II filament assembly" NARROW [GOC:TermGenie] synonym: "inhibition of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "negative regulation of myosin II polymerization" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0043520 ! regulation of myosin II filament assembly is_a: GO:1904900 ! negative regulation of myosin II filament organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031036 ! myosin II filament assembly relationship: negatively_regulates GO:0031036 ! myosin II filament assembly created_by: pf creation_date: 2016-09-28T13:47:56Z [Term] id: GO:1905511 name: positive regulation of myosin II filament assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416] comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules synonym: "activation of myosin II filament assembly" NARROW [GOC:TermGenie] synonym: "activation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "positive regulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "up regulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "up regulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "up-regulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of myosin II polymerization" RELATED [GOC:TermGenie] synonym: "upregulation of myosin II filament assembly" EXACT [GOC:TermGenie] synonym: "upregulation of myosin II polymerization" RELATED [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0043520 ! regulation of myosin II filament assembly is_a: GO:1904901 ! positive regulation of myosin II filament organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031036 ! myosin II filament assembly relationship: positively_regulates GO:0031036 ! myosin II filament assembly created_by: pf creation_date: 2016-09-28T13:48:03Z [Term] id: GO:1905512 name: regulation of short-term synaptic potentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] synonym: "regulation of synaptic facilitation" EXACT [GOC:TermGenie] is_a: GO:0048167 ! regulation of synaptic plasticity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990926 ! short-term synaptic potentiation relationship: regulates GO:1990926 ! short-term synaptic potentiation created_by: hjd creation_date: 2016-09-28T17:40:15Z [Term] id: GO:1905513 name: negative regulation of short-term synaptic potentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] synonym: "down regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "down regulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "down-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "downregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "downregulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "inhibition of short-term synaptic potentiation" NARROW [GOC:TermGenie] synonym: "inhibition of synaptic facilitation" NARROW [GOC:TermGenie] synonym: "negative regulation of synaptic facilitation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905512 ! regulation of short-term synaptic potentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990926 ! short-term synaptic potentiation relationship: negatively_regulates GO:1990926 ! short-term synaptic potentiation created_by: hjd creation_date: 2016-09-28T17:40:23Z [Term] id: GO:1905514 name: positive regulation of short-term synaptic potentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] synonym: "activation of short-term synaptic potentiation" NARROW [GOC:TermGenie] synonym: "activation of synaptic facilitation" NARROW [GOC:TermGenie] synonym: "positive regulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "up regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "up regulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "up-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of synaptic facilitation" EXACT [GOC:TermGenie] synonym: "upregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] synonym: "upregulation of synaptic facilitation" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905512 ! regulation of short-term synaptic potentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990926 ! short-term synaptic potentiation relationship: positively_regulates GO:1990926 ! short-term synaptic potentiation created_by: hjd creation_date: 2016-09-28T17:40:30Z [Term] id: GO:1905515 name: non-motile cilium assembly namespace: biological_process alt_id: GO:0035058 def: "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834] synonym: "immotile primary cilium assembly" RELATED [GOC:bf] synonym: "non-motile cilium formation" EXACT [GOC:TermGenie] synonym: "nonmotile cilium assembly" EXACT [GOC:TermGenie] synonym: "nonmotile cilium formation" EXACT [GOC:TermGenie] synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf] synonym: "nonmotile primary cilium assembly" RELATED [] synonym: "sensory cilium assembly" RELATED [GOC:kmv] synonym: "sensory cilium biogenesis" RELATED [GOC:mah] is_a: GO:0060271 ! cilium assembly created_by: pr creation_date: 2016-09-30T11:55:15Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009566 ! fertilization relationship: positively_regulates GO:0009566 ! fertilization created_by: pr creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905517 name: macrophage migration namespace: biological_process def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876] is_a: GO:0097529 ! myeloid leukocyte migration created_by: sl creation_date: 2016-09-30T22:17:45Z [Term] id: GO:1905518 name: regulation of presynaptic active zone assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] synonym: "regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904071 ! presynaptic active zone assembly relationship: regulates GO:1904071 ! presynaptic active zone assembly created_by: rl creation_date: 2016-10-01T09:37:51Z [Term] id: GO:1905519 name: negative regulation of presynaptic active zone assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] synonym: "down regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "down regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "down regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "down regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "down-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "down-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "down-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "downregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "downregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "downregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "downregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "inhibition of pre-synaptic active zone assembly" NARROW [GOC:TermGenie] synonym: "inhibition of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "inhibition of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "inhibition of pre-synaptic active zone formation" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic active zone assembly" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic active zone formation" NARROW [GOC:TermGenie] synonym: "negative regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "negative regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] is_a: GO:1905518 ! regulation of presynaptic active zone assembly is_a: GO:1905607 ! negative regulation of presynapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904071 ! presynaptic active zone assembly relationship: negatively_regulates GO:1904071 ! presynaptic active zone assembly created_by: rl creation_date: 2016-10-01T09:38:00Z [Term] id: GO:1905520 name: positive regulation of presynaptic active zone assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] synonym: "activation of pre-synaptic active zone assembly" NARROW [GOC:TermGenie] synonym: "activation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "activation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "activation of pre-synaptic active zone formation" NARROW [GOC:TermGenie] synonym: "activation of presynaptic active zone assembly" NARROW [GOC:TermGenie] synonym: "activation of presynaptic active zone formation" NARROW [GOC:TermGenie] synonym: "positive regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "positive regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "up regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "up regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "up regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "up regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "up-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "up-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "up-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] synonym: "upregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "upregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] synonym: "upregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] synonym: "upregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic active zone formation" EXACT [GOC:TermGenie] is_a: GO:1905518 ! regulation of presynaptic active zone assembly is_a: GO:1905608 ! positive regulation of presynapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904071 ! presynaptic active zone assembly relationship: positively_regulates GO:1904071 ! presynaptic active zone assembly created_by: rl creation_date: 2016-10-01T09:38:07Z [Term] id: GO:1905521 name: regulation of macrophage migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905517 ! macrophage migration relationship: regulates GO:1905517 ! macrophage migration created_by: sl creation_date: 2016-10-03T15:29:06Z [Term] id: GO:1905522 name: negative regulation of macrophage migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905517 ! macrophage migration relationship: negatively_regulates GO:1905517 ! macrophage migration created_by: sl creation_date: 2016-10-03T15:29:14Z [Term] id: GO:1905523 name: positive regulation of macrophage migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "activation of macrophage migration" NARROW [GOC:TermGenie] synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905517 ! macrophage migration relationship: positively_regulates GO:1905517 ! macrophage migration created_by: sl creation_date: 2016-10-03T15:29:21Z [Term] id: GO:1905524 name: negative regulation of protein autoubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:17237821] synonym: "down regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "down regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "down regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "down-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein autoubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "downregulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "downregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "inhibition of protein auto-ubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of protein auto-ubiquitinylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein autoubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of protein autoubiquitinylation" NARROW [GOC:TermGenie] synonym: "inhibition of protein self-ubiquitination" NARROW [GOC:TermGenie] synonym: "inhibition of protein self-ubiquitinylation" NARROW [GOC:TermGenie] synonym: "negative regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] synonym: "negative regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] synonym: "negative regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:1902498 ! regulation of protein autoubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051865 ! protein autoubiquitination relationship: negatively_regulates GO:0051865 ! protein autoubiquitination created_by: bc creation_date: 2016-10-04T10:53:25Z [Term] id: GO:1905525 name: obsolete regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter in response to iron that results in regulation of ferrichrome biosynthetic process." [GO_REF:0000063, GOC:TermGenie, PMID:20435771] comment: This term was made obsolete because it was added in error. synonym: "regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2016-10-04T15:46:03Z [Term] id: GO:1905526 name: regulation of Golgi lumen acidification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] is_a: GO:0032847 ! regulation of cellular pH reduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061795 ! Golgi lumen acidification relationship: regulates GO:0061795 ! Golgi lumen acidification created_by: dph creation_date: 2016-10-05T13:16:25Z [Term] id: GO:1905527 name: negative regulation of Golgi lumen acidification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] synonym: "down regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] synonym: "down-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] synonym: "downregulation of Golgi lumen acidification" EXACT [GOC:TermGenie] synonym: "inhibition of Golgi lumen acidification" NARROW [GOC:TermGenie] is_a: GO:0032848 ! negative regulation of cellular pH reduction is_a: GO:1905526 ! regulation of Golgi lumen acidification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061795 ! Golgi lumen acidification relationship: negatively_regulates GO:0061795 ! Golgi lumen acidification created_by: dph creation_date: 2016-10-05T13:16:33Z [Term] id: GO:1905528 name: positive regulation of Golgi lumen acidification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] synonym: "activation of Golgi lumen acidification" NARROW [GOC:TermGenie] synonym: "up regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] synonym: "up-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] synonym: "upregulation of Golgi lumen acidification" EXACT [GOC:TermGenie] is_a: GO:0032849 ! positive regulation of cellular pH reduction is_a: GO:1905526 ! regulation of Golgi lumen acidification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061795 ! Golgi lumen acidification relationship: positively_regulates GO:0061795 ! Golgi lumen acidification created_by: dph creation_date: 2016-10-05T13:16:41Z [Term] id: GO:1905529 name: regulation of uracil import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098721 ! uracil import across plasma membrane relationship: regulates GO:0098721 ! uracil import across plasma membrane created_by: vw creation_date: 2016-10-05T21:03:40Z [Term] id: GO:1905530 name: negative regulation of uracil import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:1905529 ! regulation of uracil import across plasma membrane is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098721 ! uracil import across plasma membrane relationship: negatively_regulates GO:0098721 ! uracil import across plasma membrane created_by: vw creation_date: 2016-10-05T21:03:48Z [Term] id: GO:1905531 name: positive regulation of uracil import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:1905529 ! regulation of uracil import across plasma membrane is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098721 ! uracil import across plasma membrane relationship: positively_regulates GO:0098721 ! uracil import across plasma membrane created_by: vw creation_date: 2016-10-05T21:03:56Z [Term] id: GO:1905532 name: regulation of leucine import across plasma membrane namespace: biological_process alt_id: GO:1903128 def: "Any process that modulates the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] synonym: "regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "regulation of leucine import into cell" EXACT [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098713 ! leucine import across plasma membrane relationship: regulates GO:0098713 ! leucine import across plasma membrane created_by: vw creation_date: 2014-06-25T13:09:51Z [Term] id: GO:1905533 name: negative regulation of leucine import across plasma membrane namespace: biological_process alt_id: GO:1903129 def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] synonym: "down regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "down regulation of leucine import into cell" EXACT [GOC:TermGenie] synonym: "down-regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "down-regulation of leucine import into cell" EXACT [GOC:TermGenie] synonym: "downregulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "downregulation of leucine import into cell" EXACT [GOC:TermGenie] synonym: "inhibition of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "inhibition of leucine import into cell" NARROW [GOC:TermGenie] synonym: "negative regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "negative regulation of leucine import into cell" EXACT [] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905532 ! regulation of leucine import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098713 ! leucine import across plasma membrane relationship: negatively_regulates GO:0098713 ! leucine import across plasma membrane created_by: vw creation_date: 2016-10-05T21:08:01Z [Term] id: GO:1905534 name: positive regulation of leucine import across plasma membrane namespace: biological_process alt_id: GO:1903130 def: "Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] synonym: "activation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "activation of leucine import into cell" NARROW [GOC:TermGenie] synonym: "positive regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "positive regulation of leucine import into cell" EXACT [] synonym: "up regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "up regulation of leucine import into cell" EXACT [GOC:TermGenie] synonym: "up-regulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "up-regulation of leucine import into cell" EXACT [GOC:TermGenie] synonym: "upregulation of L-leucine import into cell" NARROW [GOC:TermGenie] synonym: "upregulation of leucine import into cell" EXACT [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905532 ! regulation of leucine import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098713 ! leucine import across plasma membrane relationship: positively_regulates GO:0098713 ! leucine import across plasma membrane created_by: vw creation_date: 2014-06-25T13:10:04Z [Term] id: GO:1905535 name: regulation of eukaryotic translation initiation factor 4F complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "regulation of eIF4F assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly relationship: regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly created_by: bc creation_date: 2016-10-06T14:04:58Z [Term] id: GO:1905536 name: negative regulation of eukaryotic translation initiation factor 4F complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "down regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "down regulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "downregulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of eIF-4F assembly" NARROW [GOC:TermGenie] synonym: "inhibition of eIF4F assembly" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of eIF4F assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly relationship: negatively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly created_by: bc creation_date: 2016-10-06T14:05:06Z [Term] id: GO:1905537 name: positive regulation of eukaryotic translation initiation factor 4F complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "activation of eIF-4F assembly" NARROW [GOC:TermGenie] synonym: "activation of eIF4F assembly" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "up regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "up regulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of eIF-4F assembly" EXACT [GOC:TermGenie] synonym: "upregulation of eIF4F assembly" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly relationship: positively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly created_by: bc creation_date: 2016-10-06T14:05:13Z [Term] id: GO:1905538 name: polysome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polysome." [GO_REF:000102, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "polyribosome binding" EXACT [GOC:TermGenie] is_a: GO:0043021 ! ribonucleoprotein complex binding created_by: bc creation_date: 2016-10-07T14:02:53Z [Term] id: GO:1905539 name: regulation of postsynapse to nucleus signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway." [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005] subset: goslim_synapse synonym: "regulation of postsynaptic signaling to nucleus" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099527 ! postsynapse to nucleus signaling pathway relationship: regulates GO:0099527 ! postsynapse to nucleus signaling pathway created_by: dos creation_date: 2016-10-07T17:03:38Z [Term] id: GO:1905540 name: interleukin-7 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-7 (IL-7) and that consists of, at a minimum, an interleukin, an alpha and a gamma chain as well as optional additional kinase subunits. The alpha chain binds IL-7 with high affinity and subsequently binds the cytokine receptor common gamma chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:19141282] comment: An example of this is IL7R in human (P16871) in PMID:19141282 (inferred from direct assay). synonym: "IL-7 receptor complex" EXACT [] synonym: "IL-7-receptor complex" EXACT [] synonym: "IL7 receptor complex" EXACT [] synonym: "IL7-receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex created_by: bhm creation_date: 2016-10-10T07:44:05Z [Term] id: GO:1905541 name: regulation of L-arginine import across plasma membrane namespace: biological_process alt_id: GO:1902826 def: "Any process that modulates the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] synonym: "regulation of L-arginine import into cell" EXACT [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0010963 ! regulation of L-arginine import is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097638 ! L-arginine import across plasma membrane relationship: regulates GO:0097638 ! L-arginine import across plasma membrane creation_date: 2014-03-31T14:30:40Z [Term] id: GO:1905542 name: negative regulation of L-arginine import across plasma membrane namespace: biological_process alt_id: GO:1902827 def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] synonym: "down regulation of L-arginine import into cell" EXACT [GOC:TermGenie] synonym: "downregulation of L-arginine import into cell" EXACT [GOC:TermGenie] synonym: "inhibition of L-arginine import into cell" NARROW [GOC:TermGenie] synonym: "negative regulation of L-arginine import into cell" EXACT [] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane relationship: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane created_by: mah creation_date: 2014-03-31T14:30:46Z [Term] id: GO:1905543 name: interleukin-15 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-15 (IL-15) and that consists of, at a minimum, an interleukin, an alpha, beta and gamma chain as well as optional additional kinase subunits. The alpha chain is unique to binds IL-15 while it shares the beta chain with the IL-2 receptor and the cytokine receptor common gamma chain with multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23104097] comment: An example of this is IL15RA in human (Q13261) in PMID:23104097 (inferred from physical interaction). synonym: "IL-15 receptor complex" EXACT [] synonym: "IL-15-receptor complex" EXACT [] synonym: "IL15 receptor complex" EXACT [] synonym: "IL15-receptor complex" EXACT [] synonym: "interleukin-15-receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex created_by: bhm creation_date: 2016-10-10T13:38:12Z [Term] id: GO:1905544 name: L-methionine import across plasma membrane namespace: biological_process alt_id: GO:1903813 def: "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] synonym: "L-methionine import into cell" EXACT [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903692 ! methionine import across plasma membrane created_by: mah creation_date: 2015-01-16T15:03:17Z [Term] id: GO:1905545 name: obsolete negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron." [GO_REF:0000058, GOC:TermGenie, PMID:20435771] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] is_obsolete: true created_by: al creation_date: 2016-10-11T16:15:05Z [Term] id: GO:1905546 name: cellular response to phenylpropanoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylpropanoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0080184 ! response to phenylpropanoid created_by: sl creation_date: 2016-10-11T19:54:58Z [Term] id: GO:1905547 name: regulation of telomeric heterochromatin assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] synonym: "regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] is_a: GO:0031445 ! regulation of heterochromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031509 ! telomeric heterochromatin assembly relationship: regulates GO:0031509 ! telomeric heterochromatin assembly created_by: nc creation_date: 2016-10-12T11:14:00Z [Term] id: GO:1905548 name: negative regulation of telomeric heterochromatin assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] synonym: "down regulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "down regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "inhibition of telomeric heterochromatin assembly" NARROW [GOC:TermGenie] synonym: "inhibition of telomeric heterochromatin formation" NARROW [GOC:TermGenie] synonym: "negative regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] is_a: GO:0031452 ! negative regulation of heterochromatin assembly is_a: GO:1905547 ! regulation of telomeric heterochromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031509 ! telomeric heterochromatin assembly relationship: negatively_regulates GO:0031509 ! telomeric heterochromatin assembly created_by: nc creation_date: 2016-10-12T11:18:23Z [Term] id: GO:1905549 name: positive regulation of telomeric heterochromatin assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] synonym: "activation of telomeric heterochromatin assembly" NARROW [GOC:TermGenie] synonym: "activation of telomeric heterochromatin formation" NARROW [GOC:TermGenie] synonym: "positive regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "up regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric heterochromatin assembly" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric heterochromatin formation" EXACT [GOC:TermGenie] is_a: GO:0031453 ! positive regulation of heterochromatin assembly is_a: GO:1905547 ! regulation of telomeric heterochromatin assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031509 ! telomeric heterochromatin assembly relationship: positively_regulates GO:0031509 ! telomeric heterochromatin assembly created_by: nc creation_date: 2016-10-12T11:18:30Z [Term] id: GO:1905550 name: regulation of protein localization to endoplasmic reticulum namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] synonym: "regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in ER" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070972 ! protein localization to endoplasmic reticulum relationship: regulates GO:0070972 ! protein localization to endoplasmic reticulum created_by: rz creation_date: 2016-10-12T11:37:01Z [Term] id: GO:1905551 name: negative regulation of protein localization to endoplasmic reticulum namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] synonym: "down regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in ER" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in ER" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070972 ! protein localization to endoplasmic reticulum relationship: negatively_regulates GO:0070972 ! protein localization to endoplasmic reticulum created_by: rz creation_date: 2016-10-12T11:37:08Z [Term] id: GO:1905552 name: positive regulation of protein localization to endoplasmic reticulum namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] synonym: "activation of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "activation of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "activation of protein localization in ER" NARROW [GOC:TermGenie] synonym: "activation of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in ER" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070972 ! protein localization to endoplasmic reticulum relationship: positively_regulates GO:0070972 ! protein localization to endoplasmic reticulum created_by: rz creation_date: 2016-10-12T11:37:16Z [Term] id: GO:1905553 name: regulation of blood vessel branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001569 ! branching involved in blood vessel morphogenesis relationship: regulates GO:0001569 ! branching involved in blood vessel morphogenesis created_by: nc creation_date: 2016-10-12T14:19:33Z [Term] id: GO:1905554 name: negative regulation of vessel branching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis relationship: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis created_by: nc creation_date: 2016-10-12T14:19:41Z [Term] id: GO:1905555 name: positive regulation blood vessel branching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis relationship: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis created_by: nc creation_date: 2016-10-12T14:19:49Z [Term] id: GO:1905556 name: ciliary vesicle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary vesicle. Multiple smaller vesicles dock to the transitional fibers on a mature basal body and then fuse together to form a larger single vesicle. This then fuses with the plasma membrane and forms the ciliary membrane." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:13978319, PMID:25313408, PMID:25805133, PMID:25812525] synonym: "ciliary vesicle formation" EXACT [GOC:TermGenie] synonym: "CV assembly" RELATED [GOC:TermGenie] synonym: "CV formation" RELATED [GOC:TermGenie] synonym: "primary ciliary vesicle assembly" EXACT [GOC:TermGenie] synonym: "primary ciliary vesicle formation" EXACT [GOC:TermGenie] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly created_by: pr creation_date: 2016-10-13T09:31:06Z [Term] id: GO:1905557 name: regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007077 ! mitotic nuclear envelope disassembly relationship: regulates GO:0007077 ! mitotic nuclear envelope disassembly created_by: hbye creation_date: 2016-10-14T13:14:57Z [Term] id: GO:1905558 name: negative regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007077 ! mitotic nuclear envelope disassembly relationship: negatively_regulates GO:0007077 ! mitotic nuclear envelope disassembly created_by: hbye creation_date: 2016-10-14T13:15:08Z [Term] id: GO:1905559 name: positive regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007077 ! mitotic nuclear envelope disassembly relationship: positively_regulates GO:0007077 ! mitotic nuclear envelope disassembly created_by: hbye creation_date: 2016-10-14T13:15:17Z [Term] id: GO:1905560 name: negative regulation of kinetochore assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "down regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "down regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "down regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "down regulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "down regulation of kinetochore biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "down-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "down-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "down-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "down-regulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "downregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "downregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "downregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "downregulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "downregulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "inhibition of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "inhibition of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "inhibition of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "inhibition of kinetochore assembly" NARROW [GOC:TermGenie] synonym: "inhibition of kinetochore formation" RELATED [GOC:TermGenie] synonym: "negative regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "negative regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "negative regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "negative regulation of kinetochore formation" RELATED [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0090234 ! regulation of kinetochore assembly is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051382 ! kinetochore assembly relationship: negatively_regulates GO:0051382 ! kinetochore assembly created_by: hbye creation_date: 2016-10-14T13:47:38Z [Term] id: GO:1905561 name: positive regulation of kinetochore assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "activation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "activation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "activation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "activation of kinetochore assembly" NARROW [GOC:TermGenie] synonym: "activation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "positive regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "positive regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "positive regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "positive regulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "up regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "up regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "up regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "up regulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "up regulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "up-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "up-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "up-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "up-regulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of kinetochore formation" RELATED [GOC:TermGenie] synonym: "upregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "upregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] synonym: "upregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] synonym: "upregulation of kinetochore assembly" EXACT [GOC:TermGenie] synonym: "upregulation of kinetochore formation" RELATED [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0090234 ! regulation of kinetochore assembly is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051382 ! kinetochore assembly relationship: positively_regulates GO:0051382 ! kinetochore assembly created_by: hbye creation_date: 2016-10-14T13:47:45Z [Term] id: GO:1905562 name: regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] is_a: GO:0001936 ! regulation of endothelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0101023 ! vascular endothelial cell proliferation relationship: regulates GO:0101023 ! vascular endothelial cell proliferation created_by: nc creation_date: 2016-10-17T09:24:17Z [Term] id: GO:1905563 name: negative regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0001937 ! negative regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation relationship: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation created_by: nc creation_date: 2016-10-17T09:24:26Z [Term] id: GO:1905564 name: positive regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0001938 ! positive regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0101023 ! vascular endothelial cell proliferation relationship: positively_regulates GO:0101023 ! vascular endothelial cell proliferation created_by: nc creation_date: 2016-10-17T09:24:35Z [Term] id: GO:1905565 name: obsolete regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] is_obsolete: true created_by: nc creation_date: 2016-10-18T10:58:29Z [Term] id: GO:1905566 name: obsolete negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] is_obsolete: true created_by: nc creation_date: 2016-10-18T10:58:46Z [Term] id: GO:1905567 name: obsolete positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] is_obsolete: true created_by: nc creation_date: 2016-10-18T10:58:54Z [Term] id: GO:1905568 name: regulation of ferrichrome biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie] synonym: "regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900704 ! regulation of siderophore biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031169 ! ferrichrome biosynthetic process relationship: regulates GO:0031169 ! ferrichrome biosynthetic process created_by: pr creation_date: 2016-10-18T14:49:00Z [Term] id: GO:1905569 name: negative regulation of ferrichrome biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321] synonym: "down regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "down regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "down-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "down-regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "downregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "downregulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "downregulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of ferrichrome anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome formation" NARROW [GOC:TermGenie] synonym: "inhibition of ferrichrome synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "negative regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900705 ! negative regulation of siderophore biosynthetic process is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031169 ! ferrichrome biosynthetic process relationship: negatively_regulates GO:0031169 ! ferrichrome biosynthetic process created_by: pr creation_date: 2016-10-18T14:49:08Z [Term] id: GO:1905570 name: positive regulation of ferrichrome biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321] synonym: "activation of ferrichrome anabolism" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome formation" NARROW [GOC:TermGenie] synonym: "activation of ferrichrome synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "positive regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "up regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "up-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "up-regulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ferrichrome anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] synonym: "upregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] synonym: "upregulation of ferrichrome formation" EXACT [GOC:TermGenie] synonym: "upregulation of ferrichrome synthesis" EXACT [GOC:TermGenie] is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900706 ! positive regulation of siderophore biosynthetic process is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031169 ! ferrichrome biosynthetic process relationship: positively_regulates GO:0031169 ! ferrichrome biosynthetic process created_by: pr creation_date: 2016-10-18T14:49:16Z [Term] id: GO:1905571 name: interleukin-10 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16982608] comment: An example of this is IL10RA in human (UniProt symbol Q13651) in PMID:16982608 (inferred from physical interaction). synonym: "IL-10 receptor complex" EXACT [] synonym: "IL-10-receptor complex" EXACT [] synonym: "IL10 receptor complex" EXACT [] synonym: "interleukin-10-receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex created_by: bhm creation_date: 2016-10-19T09:45:22Z [Term] id: GO:1905572 name: ganglioside GM1 transport to membrane namespace: biological_process def: "The directed movement of ganglioside GM1 to membrane." [GO_REF:0000078, GOC:TermGenie, PMID:1454804] is_a: GO:0035627 ! ceramide transport is_a: GO:0046836 ! glycolipid transport is_a: GO:0046942 ! carboxylic acid transport created_by: pga creation_date: 2016-10-19T10:50:44Z [Term] id: GO:1905573 name: ganglioside GM1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ganglioside GM1." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0035594 ! ganglioside binding created_by: pga creation_date: 2016-10-19T10:57:28Z [Term] id: GO:1905574 name: ganglioside GM2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ganglioside GM2." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0035594 ! ganglioside binding created_by: pga creation_date: 2016-10-19T11:17:01Z [Term] id: GO:1905575 name: ganglioside GM3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ganglioside GM3." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0035594 ! ganglioside binding created_by: pga creation_date: 2016-10-19T11:17:10Z [Term] id: GO:1905576 name: ganglioside GT1b binding namespace: molecular_function def: "Interacting selectively and non-covalently with ganglioside GT1b." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0035594 ! ganglioside binding created_by: pga creation_date: 2016-10-19T11:17:17Z [Term] id: GO:1905577 name: ganglioside GP1c binding namespace: molecular_function def: "Interacting selectively and non-covalently with ganglioside GP1c." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0035594 ! ganglioside binding created_by: pga creation_date: 2016-10-19T11:17:25Z [Term] id: GO:1905578 name: regulation of ERBB3 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] synonym: "regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1901184 ! regulation of ERBB signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038129 ! ERBB3 signaling pathway relationship: regulates GO:0038129 ! ERBB3 signaling pathway created_by: als creation_date: 2016-10-19T11:46:55Z [Term] id: GO:1905579 name: negative regulation of ERBB3 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] synonym: "down regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of ERBB3 signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of ERBB3 signalling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of HER3 signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1901185 ! negative regulation of ERBB signaling pathway is_a: GO:1905578 ! regulation of ERBB3 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038129 ! ERBB3 signaling pathway relationship: negatively_regulates GO:0038129 ! ERBB3 signaling pathway created_by: als creation_date: 2016-10-19T11:47:03Z [Term] id: GO:1905580 name: positive regulation of ERBB3 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] synonym: "activation of ERBB3 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of ERBB3 signalling pathway" NARROW [GOC:TermGenie] synonym: "activation of HER3 signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of HER3 signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] is_a: GO:1901186 ! positive regulation of ERBB signaling pathway is_a: GO:1905578 ! regulation of ERBB3 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038129 ! ERBB3 signaling pathway relationship: positively_regulates GO:0038129 ! ERBB3 signaling pathway created_by: als creation_date: 2016-10-19T11:47:11Z [Term] id: GO:1905581 name: positive regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "activation of LDL clearance" NARROW [GOC:TermGenie] synonym: "activation of low-density lipoprotein particle clearance" NARROW [GOC:TermGenie] synonym: "positive regulation of LDL clearance" EXACT [GOC:TermGenie] synonym: "up regulation of LDL clearance" EXACT [GOC:TermGenie] synonym: "up regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] synonym: "up-regulation of LDL clearance" EXACT [GOC:TermGenie] synonym: "up-regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] synonym: "upregulation of LDL clearance" EXACT [GOC:TermGenie] synonym: "upregulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034383 ! low-density lipoprotein particle clearance relationship: positively_regulates GO:0034383 ! low-density lipoprotein particle clearance created_by: nc creation_date: 2016-10-19T14:39:15Z [Term] id: GO:1905582 name: response to mannose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509] is_a: GO:0009746 ! response to hexose created_by: pga creation_date: 2016-10-21T11:40:40Z [Term] id: GO:1905583 name: cellular response to mannose namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509] is_a: GO:0071331 ! cellular response to hexose stimulus is_a: GO:1905582 ! response to mannose created_by: pga creation_date: 2016-10-21T11:40:47Z [Term] id: GO:1905584 name: outer hair cell apoptotic process namespace: biological_process def: "Any apoptotic process in an outer hair cell." [GO_REF:0000085, GOC:TermGenie, PMID:12062759, PMID:24472721] synonym: "cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1904019 ! epithelial cell apoptotic process created_by: sl creation_date: 2016-10-21T22:42:13Z [Term] id: GO:1905585 name: regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043523 ! regulation of neuron apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905584 ! outer hair cell apoptotic process relationship: regulates GO:1905584 ! outer hair cell apoptotic process created_by: sl creation_date: 2016-10-24T22:35:34Z [Term] id: GO:1905586 name: negative regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "down regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:1905585 ! regulation of outer hair cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905584 ! outer hair cell apoptotic process relationship: negatively_regulates GO:1905584 ! outer hair cell apoptotic process created_by: sl creation_date: 2016-10-24T22:35:43Z [Term] id: GO:1905587 name: positive regulation of outer hair cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] synonym: "activation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of outer hair cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:1905585 ! regulation of outer hair cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905584 ! outer hair cell apoptotic process relationship: positively_regulates GO:1905584 ! outer hair cell apoptotic process created_by: sl creation_date: 2016-10-24T22:35:51Z [Term] id: GO:1905588 name: plant-type cell wall modification involved in stomatal movement namespace: biological_process def: "Any plant-type cell wall modification that is involved in stomatal movement." [GO_REF:0000060, GOC:TermGenie, PMID:27720618] synonym: "cellulose and pectin-containing cell wall modification involved in stomatal movement" EXACT [GOC:TermGenie] is_a: GO:0009827 ! plant-type cell wall modification intersection_of: GO:0009827 ! plant-type cell wall modification intersection_of: part_of GO:0010118 ! stomatal movement relationship: part_of GO:0010118 ! stomatal movement created_by: lr creation_date: 2016-10-25T00:29:26Z [Term] id: GO:1905589 name: positive regulation of L-arginine import across plasma membrane namespace: biological_process alt_id: GO:1901042 alt_id: GO:1902828 def: "Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] synonym: "activation of L-arginine import" NARROW [GOC:TermGenie] synonym: "activation of L-arginine import across plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of L-arginine import into cell" NARROW [GOC:TermGenie] synonym: "activation of L-arginine uptake" EXACT [GOC:TermGenie] synonym: "positive regulation of L-arginine import" BROAD [] synonym: "positive regulation of L-arginine import into cell" EXACT [] synonym: "positive regulation of L-arginine uptake" EXACT [GOC:TermGenie] synonym: "up regulation of L-arginine import" EXACT [GOC:TermGenie] synonym: "up regulation of L-arginine uptake" EXACT [GOC:TermGenie] synonym: "up-regulation of L-arginine import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-arginine import into cell" EXACT [GOC:TermGenie] synonym: "up-regulation of L-arginine uptake" EXACT [GOC:TermGenie] synonym: "upregulation of L-arginine import" EXACT [GOC:TermGenie] synonym: "upregulation of L-arginine import into cell" EXACT [GOC:TermGenie] synonym: "upregulation of L-arginine uptake" EXACT [GOC:TermGenie] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097638 ! L-arginine import across plasma membrane relationship: positively_regulates GO:0097638 ! L-arginine import across plasma membrane created_by: al creation_date: 2012-06-25T12:27:24Z [Term] id: GO:1905590 name: fibronectin fibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril." [GO_REF:000103, GOC:dph, GOC:TermGenie, PMID:20690820] is_a: GO:0097435 ! supramolecular fiber organization created_by: dph creation_date: 2016-10-25T12:04:50Z [Term] id: GO:1905591 name: regulation of optical nerve axon regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] is_a: GO:0048679 ! regulation of axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0101027 ! optical nerve axon regeneration relationship: regulates GO:0101027 ! optical nerve axon regeneration created_by: pga creation_date: 2016-10-25T12:58:43Z [Term] id: GO:1905592 name: negative regulation of optical nerve axon regeneration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] synonym: "down regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] synonym: "down-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] synonym: "downregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of optical nerve axon regeneration" NARROW [GOC:TermGenie] is_a: GO:0048681 ! negative regulation of axon regeneration is_a: GO:1905591 ! regulation of optical nerve axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0101027 ! optical nerve axon regeneration relationship: negatively_regulates GO:0101027 ! optical nerve axon regeneration created_by: pga creation_date: 2016-10-25T12:58:50Z [Term] id: GO:1905593 name: positive regulation of optical nerve axon regeneration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] synonym: "activation of optical nerve axon regeneration" NARROW [GOC:TermGenie] synonym: "up regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] synonym: "up-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] is_a: GO:0048680 ! positive regulation of axon regeneration is_a: GO:1905591 ! regulation of optical nerve axon regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0101027 ! optical nerve axon regeneration relationship: positively_regulates GO:0101027 ! optical nerve axon regeneration created_by: pga creation_date: 2016-10-25T12:58:58Z [Term] id: GO:1905594 name: resveratrol binding namespace: molecular_function def: "Interacting selectively and non-covalently with resveratrol." [GO_REF:0000067, GOC:TermGenie, PMID:18254726] comment: (5-(aziridin-1-yl)-2,4-dinitrobenzamide is_a: GO:0097159 ! organic cyclic compound binding created_by: pga creation_date: 2016-10-25T15:23:37Z [Term] id: GO:1905595 name: regulation of low-density lipoprotein particle receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050750 ! low-density lipoprotein particle receptor binding relationship: regulates GO:0050750 ! low-density lipoprotein particle receptor binding created_by: nc creation_date: 2016-10-26T10:57:23Z [Term] id: GO:1905596 name: negative regulation of low-density lipoprotein particle receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "down regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "down-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of LDL receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie] synonym: "negative regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "negative regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] is_a: GO:1900121 ! negative regulation of receptor binding is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050750 ! low-density lipoprotein particle receptor binding relationship: negatively_regulates GO:0050750 ! low-density lipoprotein particle receptor binding created_by: nc creation_date: 2016-10-26T10:57:31Z [Term] id: GO:1905597 name: positive regulation of low-density lipoprotein particle receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "activation of LDL receptor binding" NARROW [GOC:TermGenie] synonym: "activation of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie] synonym: "activation of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie] synonym: "positive regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "positive regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "up regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "up regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "up regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "up-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of LDL receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] is_a: GO:1900122 ! positive regulation of receptor binding is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050750 ! low-density lipoprotein particle receptor binding relationship: positively_regulates GO:0050750 ! low-density lipoprotein particle receptor binding created_by: nc creation_date: 2016-10-26T10:57:40Z [Term] id: GO:1905598 name: negative regulation of low-density lipoprotein receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "down regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "down regulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "down regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] synonym: "down-regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "down-regulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "down-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] synonym: "downregulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "downregulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "downregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] synonym: "inhibition of LDL receptor" NARROW [GOC:TermGenie] synonym: "inhibition of LDLR activity" NARROW [GOC:TermGenie] synonym: "inhibition of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie] synonym: "negative regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "negative regulation of LDLR activity" EXACT [GOC:TermGenie] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0045806 ! negative regulation of endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005041 ! low-density lipoprotein particle receptor activity relationship: negatively_regulates GO:0005041 ! low-density lipoprotein particle receptor activity created_by: nc creation_date: 2016-10-26T11:53:34Z [Term] id: GO:1905599 name: positive regulation of low-density lipoprotein receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "activation of LDL receptor" NARROW [GOC:TermGenie] synonym: "activation of LDLR activity" NARROW [GOC:TermGenie] synonym: "activation of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie] synonym: "positive regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "positive regulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "up regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "up regulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "up regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] synonym: "up-regulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "up-regulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "up-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] synonym: "upregulation of LDL receptor" EXACT [GOC:TermGenie] synonym: "upregulation of LDLR activity" EXACT [GOC:TermGenie] synonym: "upregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0045807 ! positive regulation of endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005041 ! low-density lipoprotein particle receptor activity relationship: positively_regulates GO:0005041 ! low-density lipoprotein particle receptor activity created_by: nc creation_date: 2016-10-26T11:53:41Z [Term] id: GO:1905600 name: regulation of receptor-mediated endocytosis involved in cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] is_a: GO:0032383 ! regulation of intracellular cholesterol transport is_a: GO:0048259 ! regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport relationship: regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport created_by: pr creation_date: 2016-10-26T13:01:45Z [Term] id: GO:1905601 name: negative regulation of receptor-mediated endocytosis involved in cholesterol transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "down regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] is_a: GO:0032384 ! negative regulation of intracellular cholesterol transport is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport relationship: negatively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport created_by: pr creation_date: 2016-10-26T13:01:52Z [Term] id: GO:1905602 name: positive regulation of receptor-mediated endocytosis involved in cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] synonym: "activation of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] is_a: GO:0032385 ! positive regulation of intracellular cholesterol transport is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport relationship: positively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport created_by: pr creation_date: 2016-10-26T13:01:59Z [Term] id: GO:1905603 name: regulation of maintenance of permeability of blood-brain barrier namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of permeability of blood-brain barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22524708] synonym: "regulation of maintenance of BBB" EXACT [GOC:TermGenie] is_a: GO:0050789 ! regulation of biological process is_a: GO:0065008 ! regulation of biological quality intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035633 ! maintenance of permeability of blood-brain barrier relationship: regulates GO:0035633 ! maintenance of permeability of blood-brain barrier created_by: als creation_date: 2016-10-26T13:18:16Z [Term] id: GO:1905604 name: negative regulation of maintenance of permeability of blood-brain barrier namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of permeability of blood-brain barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22524708] synonym: "down regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "down regulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "down-regulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "downregulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] synonym: "inhibition of maintenance of permeability of BBB" NARROW [GOC:TermGenie] synonym: "inhibition of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie] synonym: "negative regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905603 ! regulation of maintenance of permeability of blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035633 ! maintenance of permeability of blood-brain barrier relationship: negatively_regulates GO:0035633 ! maintenance of permeability of blood-brain barrier created_by: als creation_date: 2016-10-26T13:18:25Z [Term] id: GO:1905605 name: positive regulation of maintenance of permeability of blood-brain barrier namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of permeability of blood-brain barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22524708] synonym: "activation of maintenance of permeability of BBB" NARROW [GOC:TermGenie] synonym: "activation of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie] synonym: "positive regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "up regulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "up-regulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of permeability of BBB" EXACT [GOC:TermGenie] synonym: "upregulation of maintenance of permeability of blood-brain barrier" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905603 ! regulation of maintenance of permeability of blood-brain barrier intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035633 ! maintenance of permeability of blood-brain barrier relationship: positively_regulates GO:0035633 ! maintenance of permeability of blood-brain barrier created_by: als creation_date: 2016-10-26T13:18:32Z [Term] id: GO:1905606 name: regulation of presynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] subset: goslim_synapse synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099054 ! presynapse assembly relationship: regulates GO:0099054 ! presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:13Z [Term] id: GO:1905607 name: negative regulation of presynapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0099054 ! presynapse assembly relationship: negatively_regulates GO:0099054 ! presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:20Z [Term] id: GO:1905608 name: positive regulation of presynapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie] synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051965 ! positive regulation of synapse assembly is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099054 ! presynapse assembly relationship: positively_regulates GO:0099054 ! presynapse assembly created_by: bc creation_date: 2016-10-27T16:08:28Z [Term] id: GO:1905609 name: positive regulation of smooth muscle cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GO_REF:0000058, GOC:TermGenie, PMID:14970114] synonym: "activation of smooth muscle cell-matrix adhesion" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] is_a: GO:0001954 ! positive regulation of cell-matrix adhesion is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion relationship: positively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion created_by: sl creation_date: 2016-10-27T21:58:11Z [Term] id: GO:1905610 name: regulation of mRNA cap binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] is_a: GO:1902415 ! regulation of mRNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098808 ! mRNA cap binding relationship: regulates GO:0098808 ! mRNA cap binding created_by: bc creation_date: 2016-10-28T11:27:28Z [Term] id: GO:1905611 name: negative regulation of mRNA cap binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] synonym: "down regulation of mRNA cap binding" EXACT [GOC:TermGenie] synonym: "down-regulation of mRNA cap binding" EXACT [GOC:TermGenie] synonym: "downregulation of mRNA cap binding" EXACT [GOC:TermGenie] synonym: "inhibition of mRNA cap binding" NARROW [GOC:TermGenie] is_a: GO:1904572 ! negative regulation of mRNA binding is_a: GO:1905610 ! regulation of mRNA cap binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098808 ! mRNA cap binding relationship: negatively_regulates GO:0098808 ! mRNA cap binding created_by: bc creation_date: 2016-10-28T11:27:36Z [Term] id: GO:1905612 name: positive regulation of mRNA cap binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] synonym: "activation of mRNA cap binding" NARROW [GOC:TermGenie] synonym: "up regulation of mRNA cap binding" EXACT [GOC:TermGenie] synonym: "up-regulation of mRNA cap binding" EXACT [GOC:TermGenie] synonym: "upregulation of mRNA cap binding" EXACT [GOC:TermGenie] is_a: GO:1902416 ! positive regulation of mRNA binding is_a: GO:1905610 ! regulation of mRNA cap binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098808 ! mRNA cap binding relationship: positively_regulates GO:0098808 ! mRNA cap binding created_by: bc creation_date: 2016-10-28T11:27:43Z [Term] id: GO:1905613 name: regulation of developmental vegetative growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080186 ! developmental vegetative growth relationship: regulates GO:0080186 ! developmental vegetative growth created_by: pga creation_date: 2016-10-28T11:45:13Z [Term] id: GO:1905614 name: negative regulation of developmental vegetative growth namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] synonym: "down regulation of developmental vegetative growth" EXACT [GOC:TermGenie] synonym: "down-regulation of developmental vegetative growth" EXACT [GOC:TermGenie] synonym: "downregulation of developmental vegetative growth" EXACT [GOC:TermGenie] synonym: "inhibition of developmental vegetative growth" NARROW [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:1905613 ! regulation of developmental vegetative growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0080186 ! developmental vegetative growth relationship: negatively_regulates GO:0080186 ! developmental vegetative growth created_by: pga creation_date: 2016-10-28T11:45:20Z [Term] id: GO:1905615 name: positive regulation of developmental vegetative growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] synonym: "activation of developmental vegetative growth" NARROW [GOC:TermGenie] synonym: "up regulation of developmental vegetative growth" EXACT [GOC:TermGenie] synonym: "up-regulation of developmental vegetative growth" EXACT [GOC:TermGenie] synonym: "upregulation of developmental vegetative growth" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:1905613 ! regulation of developmental vegetative growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0080186 ! developmental vegetative growth relationship: positively_regulates GO:0080186 ! developmental vegetative growth created_by: pga creation_date: 2016-10-28T11:45:28Z [Term] id: GO:1905616 name: regulation of miRNA mediated inhibition of translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of miRNA mediated inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] synonym: "regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] is_a: GO:0006417 ! regulation of translation is_a: GO:0060964 ! regulation of gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035278 ! miRNA mediated inhibition of translation relationship: regulates GO:0035278 ! miRNA mediated inhibition of translation created_by: bc creation_date: 2016-10-28T11:47:49Z [Term] id: GO:1905617 name: negative regulation of miRNA mediated inhibition of translation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA mediated inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] synonym: "down regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "down regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "down regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "down regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "down regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "down-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "down-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "down-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "down-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "downregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "downregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "downregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "downregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "downregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "downregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "downregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "downregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "inhibition of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "inhibition of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "inhibition of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "inhibition of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie] synonym: "inhibition of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "inhibition of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie] synonym: "inhibition of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "inhibition of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie] synonym: "negative regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "negative regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "negative regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "negative regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "negative regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "negative regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "negative regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0060965 ! negative regulation of gene silencing by miRNA is_a: GO:1905616 ! regulation of miRNA mediated inhibition of translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035278 ! miRNA mediated inhibition of translation relationship: negatively_regulates GO:0035278 ! miRNA mediated inhibition of translation created_by: bc creation_date: 2016-10-28T11:47:57Z [Term] id: GO:1905618 name: positive regulation of miRNA mediated inhibition of translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of miRNA mediated inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] synonym: "activation of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "activation of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "activation of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "activation of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie] synonym: "activation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "activation of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie] synonym: "activation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "activation of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie] synonym: "positive regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "positive regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "positive regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "positive regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "positive regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "positive regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "positive regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "up regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "up regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "up regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "up regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "up regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "up-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "up-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "up-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "up-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] synonym: "upregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "upregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "upregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] synonym: "upregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] synonym: "upregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] synonym: "upregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] synonym: "upregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] synonym: "upregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] is_a: GO:1905616 ! regulation of miRNA mediated inhibition of translation is_a: GO:2000637 ! positive regulation of gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035278 ! miRNA mediated inhibition of translation relationship: positively_regulates GO:0035278 ! miRNA mediated inhibition of translation created_by: bc creation_date: 2016-10-28T11:48:04Z [Term] id: GO:1905619 name: regulation of alpha-(1->3)-fucosyltransferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] synonym: "regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity relationship: regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity created_by: rz creation_date: 2016-10-28T14:39:37Z [Term] id: GO:1905620 name: negative regulation of alpha-(1->3)-fucosyltransferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] synonym: "down regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1905619 ! regulation of alpha-(1->3)-fucosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity relationship: negatively_regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity created_by: rz creation_date: 2016-10-28T14:39:45Z [Term] id: GO:1905621 name: positive regulation of alpha-(1->3)-fucosyltransferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] synonym: "activation of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "activation of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1905619 ! regulation of alpha-(1->3)-fucosyltransferase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity relationship: positively_regulates GO:0046920 ! alpha-(1->3)-fucosyltransferase activity created_by: rz creation_date: 2016-10-28T14:39:52Z [Term] id: GO:1905622 name: negative regulation of leaf development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] synonym: "down regulation of leaf development" EXACT [GOC:TermGenie] synonym: "down-regulation of leaf development" EXACT [GOC:TermGenie] synonym: "downregulation of leaf development" EXACT [GOC:TermGenie] synonym: "inhibition of leaf development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000024 ! regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048366 ! leaf development relationship: negatively_regulates GO:0048366 ! leaf development created_by: pga creation_date: 2016-10-28T15:29:57Z [Term] id: GO:1905623 name: positive regulation of leaf development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] synonym: "activation of leaf development" NARROW [GOC:TermGenie] synonym: "up regulation of leaf development" EXACT [GOC:TermGenie] synonym: "up-regulation of leaf development" EXACT [GOC:TermGenie] synonym: "upregulation of leaf development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000024 ! regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048366 ! leaf development relationship: positively_regulates GO:0048366 ! leaf development created_by: pga creation_date: 2016-10-28T15:30:04Z [Term] id: GO:1905624 name: regulation of L-methionine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905544 ! L-methionine import across plasma membrane relationship: regulates GO:1905544 ! L-methionine import across plasma membrane created_by: vw creation_date: 2016-10-29T16:27:29Z [Term] id: GO:1905625 name: negative regulation of L-methionine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane relationship: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane created_by: vw creation_date: 2016-10-29T16:27:38Z [Term] id: GO:1905626 name: positive regulation of L-methionine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905544 ! L-methionine import across plasma membrane relationship: positively_regulates GO:1905544 ! L-methionine import across plasma membrane created_by: vw creation_date: 2016-10-29T16:27:46Z [Term] id: GO:1905627 name: regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042427 ! serotonin biosynthetic process relationship: regulates GO:0042427 ! serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:20Z [Term] id: GO:1905628 name: negative regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042427 ! serotonin biosynthetic process relationship: negatively_regulates GO:0042427 ! serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:28Z [Term] id: GO:1905629 name: positive regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of serotonin formation" NARROW [GOC:TermGenie] synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042427 ! serotonin biosynthetic process relationship: positively_regulates GO:0042427 ! serotonin biosynthetic process created_by: pad creation_date: 2016-10-31T14:26:36Z [Term] id: GO:1905630 name: response to glyceraldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826] is_a: GO:0034284 ! response to monosaccharide created_by: sl creation_date: 2016-10-31T16:32:19Z [Term] id: GO:1905631 name: cellular response to glyceraldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826] is_a: GO:0071326 ! cellular response to monosaccharide stimulus is_a: GO:1905630 ! response to glyceraldehyde created_by: sl creation_date: 2016-10-31T16:32:27Z [Term] id: GO:1905632 name: protein localization to euchromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071168 ! protein localization to chromatin created_by: pga creation_date: 2016-11-01T16:16:14Z [Term] id: GO:1905633 name: establishment of protein localization to euchromatin namespace: biological_process def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071169 ! establishment of protein localization to chromatin is_a: GO:1905632 ! protein localization to euchromatin created_by: pga creation_date: 2016-11-01T16:16:22Z [Term] id: GO:1905634 name: regulation of protein localization to chromatin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071168 ! protein localization to chromatin relationship: regulates GO:0071168 ! protein localization to chromatin created_by: pga creation_date: 2016-11-01T16:33:52Z [Term] id: GO:1905635 name: FACT complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a FACT complex." [GO_REF:0000079, GOC:TermGenie, PMID:20889714] synonym: "Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "FACT complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: pga creation_date: 2016-11-02T15:06:03Z [Term] id: GO:1905636 name: positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531] synonym: "activation of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding relationship: positively_regulates GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding created_by: bc creation_date: 2016-11-03T12:03:07Z [Term] id: GO:1905637 name: regulation of mitochondrial mRNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0061013 ! regulation of mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000958 ! mitochondrial mRNA catabolic process relationship: regulates GO:0000958 ! mitochondrial mRNA catabolic process created_by: tb creation_date: 2016-11-03T20:23:57Z [Term] id: GO:1905638 name: negative regulation of mitochondrial mRNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] synonym: "down regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie] is_a: GO:0000961 ! negative regulation of mitochondrial RNA catabolic process is_a: GO:1902373 ! negative regulation of mRNA catabolic process is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000958 ! mitochondrial mRNA catabolic process relationship: negatively_regulates GO:0000958 ! mitochondrial mRNA catabolic process created_by: tb creation_date: 2016-11-03T20:24:05Z [Term] id: GO:1905639 name: positive regulation of mitochondrial mRNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] synonym: "activation of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie] synonym: "up regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] is_a: GO:0000962 ! positive regulation of mitochondrial RNA catabolic process is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000958 ! mitochondrial mRNA catabolic process relationship: positively_regulates GO:0000958 ! mitochondrial mRNA catabolic process created_by: tb creation_date: 2016-11-03T20:24:13Z [Term] id: GO:1905640 name: response to acetaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2016-11-04T15:07:18Z [Term] id: GO:1905641 name: cellular response to acetaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866] is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1905640 ! response to acetaldehyde created_by: mah creation_date: 2016-11-04T15:07:26Z [Term] id: GO:1905642 name: negative regulation of DNA methylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] synonym: "down regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA methylation" NARROW [GOC:TermGenie] is_a: GO:0044030 ! regulation of DNA methylation is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006306 ! DNA methylation relationship: negatively_regulates GO:0006306 ! DNA methylation created_by: bc creation_date: 2016-11-04T16:43:13Z [Term] id: GO:1905643 name: positive regulation of DNA methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] synonym: "activation of DNA methylation" NARROW [GOC:TermGenie] synonym: "up regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA methylation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA methylation" EXACT [GOC:TermGenie] is_a: GO:0044030 ! regulation of DNA methylation is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006306 ! DNA methylation relationship: positively_regulates GO:0006306 ! DNA methylation created_by: bc creation_date: 2016-11-04T16:43:22Z [Term] id: GO:1905644 name: regulation of FACT complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "regulation of FACT complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905635 ! FACT complex assembly relationship: regulates GO:1905635 ! FACT complex assembly created_by: pga creation_date: 2016-11-07T09:14:06Z [Term] id: GO:1905645 name: negative regulation of FACT complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "down regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of FACT complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of FACT complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of FACT complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905644 ! regulation of FACT complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905635 ! FACT complex assembly relationship: negatively_regulates GO:1905635 ! FACT complex assembly created_by: pga creation_date: 2016-11-07T09:14:13Z [Term] id: GO:1905646 name: positive regulation of FACT complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "activation of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie] synonym: "activation of FACT complex assembly" NARROW [GOC:TermGenie] synonym: "activation of FACT complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of FACT complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of FACT complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of FACT complex formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905644 ! regulation of FACT complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905635 ! FACT complex assembly relationship: positively_regulates GO:1905635 ! FACT complex assembly created_by: pga creation_date: 2016-11-07T09:14:21Z [Term] id: GO:1905647 name: proline import across plasma membrane namespace: biological_process alt_id: GO:1902825 def: "The directed movement of proline from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:24344203] synonym: "proline import into cell" EXACT [] is_a: GO:0035524 ! proline transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane created_by: mah creation_date: 2014-03-31T13:14:04Z [Term] id: GO:1905648 name: regulation of shell calcification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] is_a: GO:0070167 ! regulation of biomineral tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031215 ! shell calcification relationship: regulates GO:0031215 ! shell calcification created_by: pga creation_date: 2016-11-08T16:24:36Z [Term] id: GO:1905649 name: negative regulation of shell calcification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] synonym: "down regulation of shell calcification" EXACT [GOC:TermGenie] synonym: "down-regulation of shell calcification" EXACT [GOC:TermGenie] synonym: "downregulation of shell calcification" EXACT [GOC:TermGenie] synonym: "inhibition of shell calcification" NARROW [GOC:TermGenie] is_a: GO:0070168 ! negative regulation of biomineral tissue development is_a: GO:1905648 ! regulation of shell calcification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031215 ! shell calcification relationship: negatively_regulates GO:0031215 ! shell calcification created_by: pga creation_date: 2016-11-08T16:24:43Z [Term] id: GO:1905650 name: positive regulation of shell calcification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] synonym: "activation of shell calcification" NARROW [GOC:TermGenie] synonym: "up regulation of shell calcification" EXACT [GOC:TermGenie] synonym: "up-regulation of shell calcification" EXACT [GOC:TermGenie] synonym: "upregulation of shell calcification" EXACT [GOC:TermGenie] is_a: GO:0070169 ! positive regulation of biomineral tissue development is_a: GO:1905648 ! regulation of shell calcification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031215 ! shell calcification relationship: positively_regulates GO:0031215 ! shell calcification created_by: pga creation_date: 2016-11-08T16:24:51Z [Term] id: GO:1905651 name: regulation of artery morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048844 ! artery morphogenesis relationship: regulates GO:0048844 ! artery morphogenesis created_by: rph creation_date: 2016-11-09T12:19:37Z [Term] id: GO:1905652 name: negative regulation of artery morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:1905651 ! regulation of artery morphogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048844 ! artery morphogenesis relationship: negatively_regulates GO:0048844 ! artery morphogenesis created_by: rph creation_date: 2016-11-09T12:19:53Z [Term] id: GO:1905653 name: positive regulation of artery morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie] synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1904018 ! positive regulation of vasculature development is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048844 ! artery morphogenesis relationship: positively_regulates GO:0048844 ! artery morphogenesis created_by: rph creation_date: 2016-11-09T12:20:01Z [Term] id: GO:1905654 name: regulation of artery smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] is_a: GO:0003056 ! regulation of vascular smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014824 ! artery smooth muscle contraction relationship: regulates GO:0014824 ! artery smooth muscle contraction created_by: rph creation_date: 2016-11-09T12:34:46Z [Term] id: GO:1905655 name: negative regulation of artery smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "down regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of artery smooth muscle contraction" NARROW [GOC:TermGenie] is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction is_a: GO:1905654 ! regulation of artery smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014824 ! artery smooth muscle contraction relationship: negatively_regulates GO:0014824 ! artery smooth muscle contraction created_by: rph creation_date: 2016-11-09T12:34:53Z [Term] id: GO:1905656 name: positive regulation of artery smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "activation of artery smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction is_a: GO:1905654 ! regulation of artery smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014824 ! artery smooth muscle contraction relationship: positively_regulates GO:0014824 ! artery smooth muscle contraction created_by: rph creation_date: 2016-11-09T12:35:01Z [Term] id: GO:1905660 name: mitotic checkpoint complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex." [GO_REF:0000079, GOC:TermGenie, PMID:26882497] synonym: "MCC assembly" EXACT [GOC:TermGenie] synonym: "MCC formation" EXACT [GOC:TermGenie] synonym: "mitotic checkpoint complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: mah creation_date: 2016-11-09T14:17:41Z [Term] id: GO:1905661 name: regulation of telomerase RNA reverse transcriptase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] synonym: "regulation of telomerase, catalyst" EXACT [GOC:TermGenie] is_a: GO:0051972 ! regulation of telomerase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003721 ! telomerase RNA reverse transcriptase activity relationship: regulates GO:0003721 ! telomerase RNA reverse transcriptase activity created_by: nc creation_date: 2016-11-09T16:55:20Z [Term] id: GO:1905662 name: negative regulation of telomerase RNA reverse transcriptase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] synonym: "down regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "down regulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "down-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "downregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "downregulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "inhibition of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie] synonym: "inhibition of telomerase, catalyst" NARROW [GOC:TermGenie] synonym: "negative regulation of telomerase, catalyst" EXACT [GOC:TermGenie] is_a: GO:0051974 ! negative regulation of telomerase activity is_a: GO:1905661 ! regulation of telomerase RNA reverse transcriptase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003721 ! telomerase RNA reverse transcriptase activity relationship: negatively_regulates GO:0003721 ! telomerase RNA reverse transcriptase activity created_by: nc creation_date: 2016-11-09T16:55:28Z [Term] id: GO:1905663 name: positive regulation of telomerase RNA reverse transcriptase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] synonym: "activation of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie] synonym: "activation of telomerase, catalyst" NARROW [GOC:TermGenie] synonym: "positive regulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "up regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "up regulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "up-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of telomerase, catalyst" EXACT [GOC:TermGenie] synonym: "upregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] synonym: "upregulation of telomerase, catalyst" EXACT [GOC:TermGenie] is_a: GO:0051973 ! positive regulation of telomerase activity is_a: GO:1905661 ! regulation of telomerase RNA reverse transcriptase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003721 ! telomerase RNA reverse transcriptase activity relationship: positively_regulates GO:0003721 ! telomerase RNA reverse transcriptase activity created_by: nc creation_date: 2016-11-09T16:55:35Z [Term] id: GO:1905664 name: regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0090279 ! regulation of calcium ion import is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098703 ! calcium ion import across plasma membrane relationship: regulates GO:0098703 ! calcium ion import across plasma membrane created_by: bhm creation_date: 2016-11-11T09:26:06Z [Term] id: GO:1905665 name: positive regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). synonym: "activation of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] synonym: "up regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol is_a: GO:0090280 ! positive regulation of calcium ion import is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098703 ! calcium ion import across plasma membrane relationship: positively_regulates GO:0098703 ! calcium ion import across plasma membrane created_by: bhm creation_date: 2016-11-11T09:26:23Z [Term] id: GO:1905666 name: regulation of protein localization to endosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] synonym: "regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in endosome" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036010 ! protein localization to endosome relationship: regulates GO:0036010 ! protein localization to endosome created_by: bc creation_date: 2016-11-11T11:19:01Z [Term] id: GO:1905667 name: negative regulation of protein localization to endosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] synonym: "down regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to endosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to endosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to endosome" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in endosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in endosome" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to endosome" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in endosome" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905666 ! regulation of protein localization to endosome intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036010 ! protein localization to endosome relationship: negatively_regulates GO:0036010 ! protein localization to endosome created_by: bc creation_date: 2016-11-11T11:19:09Z [Term] id: GO:1905668 name: positive regulation of protein localization to endosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] synonym: "activation of protein localisation in endosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization in endosome" NARROW [GOC:TermGenie] synonym: "activation of protein localization to endosome" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in endosome" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to endosome" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905666 ! regulation of protein localization to endosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036010 ! protein localization to endosome relationship: positively_regulates GO:0036010 ! protein localization to endosome created_by: bc creation_date: 2016-11-11T11:19:17Z [Term] id: GO:1905669 name: TORC1 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] synonym: "dTOR/dRaptor complex assembly" NARROW [GOC:TermGenie] synonym: "dTOR/dRaptor complex formation" NARROW [GOC:TermGenie] synonym: "dTORC1 assembly" NARROW [GOC:TermGenie] synonym: "dTORC1 formation" NARROW [GOC:TermGenie] synonym: "mTORC1 assembly" NARROW [GOC:TermGenie] synonym: "mTORC1 formation" NARROW [GOC:TermGenie] synonym: "nutrient sensitive complex assembly" EXACT [GOC:TermGenie] synonym: "nutrient sensitive complex formation" EXACT [GOC:TermGenie] synonym: "rapamycin and nutrient-sensitive TOR complex assembly" EXACT [GOC:TermGenie] synonym: "rapamycin and nutrient-sensitive TOR complex formation" EXACT [GOC:TermGenie] synonym: "TOR complex 1 assembly" EXACT [GOC:TermGenie] synonym: "TOR complex 1 formation" EXACT [GOC:TermGenie] synonym: "TORC 1 complex assembly" EXACT [GOC:TermGenie] synonym: "TORC 1 complex formation" EXACT [GOC:TermGenie] synonym: "TORC1 assembly" EXACT [GOC:TermGenie] synonym: "TORC1 complex formation" EXACT [GOC:TermGenie] synonym: "TORC1 formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: kmv creation_date: 2016-11-11T21:03:27Z [Term] id: GO:1905670 name: TORC2 complex disassembly namespace: biological_process def: "The disaggregation of a TORC2 complex into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] synonym: "mTORC2 disassembly" NARROW [GOC:TermGenie] synonym: "rapamycin and nutrient-insensitive TOR complex disassembly" EXACT [GOC:TermGenie] synonym: "TOR complex 2 disassembly" EXACT [GOC:TermGenie] synonym: "TORC 2 complex disassembly" EXACT [GOC:TermGenie] synonym: "TORC2 disassembly" EXACT [GOC:TermGenie] is_a: GO:0032984 ! protein-containing complex disassembly created_by: kmv creation_date: 2016-11-11T21:03:37Z [Term] id: GO:1905671 name: regulation of lysosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007040 ! lysosome organization relationship: regulates GO:0007040 ! lysosome organization created_by: sl creation_date: 2016-11-11T22:01:04Z [Term] id: GO:1905672 name: negative regulation of lysosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007040 ! lysosome organization relationship: negatively_regulates GO:0007040 ! lysosome organization created_by: sl creation_date: 2016-11-11T22:01:12Z [Term] id: GO:1905673 name: positive regulation of lysosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044090 ! positive regulation of vacuole organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007040 ! lysosome organization relationship: positively_regulates GO:0007040 ! lysosome organization created_by: sl creation_date: 2016-11-11T22:01:20Z [Term] id: GO:1905674 name: regulation of adaptive immune memory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090716 ! adaptive immune memory response relationship: regulates GO:0090716 ! adaptive immune memory response created_by: tb creation_date: 2016-11-11T22:24:33Z [Term] id: GO:1905675 name: negative regulation of adaptive immune memory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] synonym: "down regulation of adaptive immune memory response" EXACT [GOC:TermGenie] synonym: "down-regulation of adaptive immune memory response" EXACT [GOC:TermGenie] synonym: "downregulation of adaptive immune memory response" EXACT [GOC:TermGenie] synonym: "inhibition of adaptive immune memory response" NARROW [GOC:TermGenie] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:1905674 ! regulation of adaptive immune memory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090716 ! adaptive immune memory response relationship: negatively_regulates GO:0090716 ! adaptive immune memory response created_by: tb creation_date: 2016-11-11T22:24:41Z [Term] id: GO:1905676 name: positive regulation of adaptive immune memory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] synonym: "activation of adaptive immune memory response" NARROW [GOC:TermGenie] synonym: "up regulation of adaptive immune memory response" EXACT [GOC:TermGenie] synonym: "up-regulation of adaptive immune memory response" EXACT [GOC:TermGenie] synonym: "upregulation of adaptive immune memory response" EXACT [GOC:TermGenie] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:1905674 ! regulation of adaptive immune memory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090716 ! adaptive immune memory response relationship: positively_regulates GO:0090716 ! adaptive immune memory response created_by: tb creation_date: 2016-11-11T22:24:49Z [Term] id: GO:1905677 name: regulation of adaptive immune effector response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090718 ! adaptive immune effector response relationship: regulates GO:0090718 ! adaptive immune effector response created_by: tb creation_date: 2016-11-11T22:24:57Z [Term] id: GO:1905678 name: negative regulation of adaptive immune effector response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] synonym: "down regulation of adaptive immune effector response" EXACT [GOC:TermGenie] synonym: "down-regulation of adaptive immune effector response" EXACT [GOC:TermGenie] synonym: "downregulation of adaptive immune effector response" EXACT [GOC:TermGenie] synonym: "inhibition of adaptive immune effector response" NARROW [GOC:TermGenie] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:1905677 ! regulation of adaptive immune effector response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090718 ! adaptive immune effector response relationship: negatively_regulates GO:0090718 ! adaptive immune effector response created_by: tb creation_date: 2016-11-11T22:25:05Z [Term] id: GO:1905679 name: positive regulation of adaptive immune effector response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] synonym: "activation of adaptive immune effector response" NARROW [GOC:TermGenie] synonym: "up regulation of adaptive immune effector response" EXACT [GOC:TermGenie] synonym: "up-regulation of adaptive immune effector response" EXACT [GOC:TermGenie] synonym: "upregulation of adaptive immune effector response" EXACT [GOC:TermGenie] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:1905677 ! regulation of adaptive immune effector response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090718 ! adaptive immune effector response relationship: positively_regulates GO:0090718 ! adaptive immune effector response created_by: tb creation_date: 2016-11-11T22:25:13Z [Term] id: GO:1905680 name: regulation of innate immunity memory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090714 ! innate immunity memory response relationship: regulates GO:0090714 ! innate immunity memory response created_by: tb creation_date: 2016-11-11T22:25:21Z [Term] id: GO:1905681 name: negative regulation of innate immunity memory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of innate immunity memory response" EXACT [GOC:TermGenie] synonym: "down-regulation of innate immunity memory response" EXACT [GOC:TermGenie] synonym: "downregulation of innate immunity memory response" EXACT [GOC:TermGenie] synonym: "inhibition of innate immunity memory response" NARROW [GOC:TermGenie] is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:1905680 ! regulation of innate immunity memory response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090714 ! innate immunity memory response relationship: negatively_regulates GO:0090714 ! innate immunity memory response created_by: tb creation_date: 2016-11-11T22:25:29Z [Term] id: GO:1905682 name: positive regulation of innate immunity memory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] synonym: "activation of innate immunity memory response" NARROW [GOC:TermGenie] synonym: "up regulation of innate immunity memory response" EXACT [GOC:TermGenie] synonym: "up-regulation of innate immunity memory response" EXACT [GOC:TermGenie] synonym: "upregulation of innate immunity memory response" EXACT [GOC:TermGenie] is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:1905680 ! regulation of innate immunity memory response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090714 ! innate immunity memory response relationship: positively_regulates GO:0090714 ! innate immunity memory response created_by: tb creation_date: 2016-11-11T22:25:36Z [Term] id: GO:1905683 name: peroxisome disassembly namespace: biological_process def: "The disaggregation of a peroxisome into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "peroxisomal disassembly" RELATED [GOC:TermGenie] is_a: GO:0007031 ! peroxisome organization is_a: GO:1903008 ! organelle disassembly created_by: pr creation_date: 2016-11-14T10:09:15Z [Term] id: GO:1905684 name: regulation of plasma membrane repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] is_a: GO:0061041 ! regulation of wound healing is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001778 ! plasma membrane repair relationship: regulates GO:0001778 ! plasma membrane repair created_by: bhm creation_date: 2016-11-14T10:30:31Z [Term] id: GO:1905685 name: negative regulation of plasma membrane repair namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] synonym: "down regulation of plasma membrane repair" EXACT [GOC:TermGenie] synonym: "down-regulation of plasma membrane repair" EXACT [GOC:TermGenie] synonym: "downregulation of plasma membrane repair" EXACT [GOC:TermGenie] synonym: "inhibition of plasma membrane repair" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1905684 ! regulation of plasma membrane repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001778 ! plasma membrane repair relationship: negatively_regulates GO:0001778 ! plasma membrane repair created_by: bhm creation_date: 2016-11-14T10:30:38Z [Term] id: GO:1905686 name: positive regulation of plasma membrane repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] synonym: "activation of plasma membrane repair" NARROW [GOC:TermGenie] synonym: "up regulation of plasma membrane repair" EXACT [GOC:TermGenie] synonym: "up-regulation of plasma membrane repair" EXACT [GOC:TermGenie] synonym: "upregulation of plasma membrane repair" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1905684 ! regulation of plasma membrane repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001778 ! plasma membrane repair relationship: positively_regulates GO:0001778 ! plasma membrane repair created_by: bhm creation_date: 2016-11-14T10:30:46Z [Term] id: GO:1905687 name: regulation of diacylglycerol kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] synonym: "regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] is_a: GO:0043549 ! regulation of kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004143 ! diacylglycerol kinase activity relationship: regulates GO:0004143 ! diacylglycerol kinase activity created_by: bc creation_date: 2016-11-14T12:26:11Z [Term] id: GO:1905688 name: negative regulation of diacylglycerol kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] synonym: "down regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "down regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "down regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "down regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "down regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "down-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "down-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "downregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "downregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DGK activity" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "downregulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "downregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "inhibition of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie] synonym: "inhibition of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "inhibition of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DG kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DGK activity" NARROW [GOC:TermGenie] synonym: "inhibition of diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of diglyceride kinase activity" NARROW [GOC:TermGenie] synonym: "inhibition of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "negative regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "negative regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:1905687 ! regulation of diacylglycerol kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004143 ! diacylglycerol kinase activity relationship: negatively_regulates GO:0004143 ! diacylglycerol kinase activity created_by: bc creation_date: 2016-11-14T12:26:18Z [Term] id: GO:1905689 name: positive regulation of diacylglycerol kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] synonym: "activation of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie] synonym: "activation of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "activation of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "activation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "activation of DG kinase activity" NARROW [GOC:TermGenie] synonym: "activation of DGK activity" NARROW [GOC:TermGenie] synonym: "activation of diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "activation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "activation of diglyceride kinase activity" NARROW [GOC:TermGenie] synonym: "activation of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "positive regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "positive regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "up regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "up regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "up regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "up-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DGK activity" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] synonym: "upregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] synonym: "upregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of DG kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DGK activity" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] synonym: "upregulation of diglyceride kinase activity" EXACT [GOC:TermGenie] synonym: "upregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] is_a: GO:0033674 ! positive regulation of kinase activity is_a: GO:1905687 ! regulation of diacylglycerol kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004143 ! diacylglycerol kinase activity relationship: positively_regulates GO:0004143 ! diacylglycerol kinase activity created_by: bc creation_date: 2016-11-14T12:26:26Z [Term] id: GO:1905690 name: nucleus disassembly namespace: biological_process def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] is_a: GO:0006997 ! nucleus organization is_a: GO:1903008 ! organelle disassembly created_by: pr creation_date: 2016-11-14T13:38:57Z [Term] id: GO:1905691 name: lipid droplet disassembly namespace: biological_process def: "The disaggregation of a lipid particle into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "adiposome disassembly" EXACT [GOC:TermGenie] synonym: "lipid body disassembly" EXACT [GOC:TermGenie] synonym: "lipid droplet reserve breakdown" EXACT [PMID:30003614] synonym: "lipid particle disassembly" EXACT [GOC:TermGenie] is_a: GO:0034389 ! lipid droplet organization is_a: GO:1903008 ! organelle disassembly created_by: pr creation_date: 2016-11-14T13:39:06Z [Term] id: GO:1905692 name: endoplasmic reticulum disassembly namespace: biological_process def: "The disaggregation of an endoplasmic reticulum into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "ER disassembly" EXACT [GOC:TermGenie] is_a: GO:0007029 ! endoplasmic reticulum organization is_a: GO:1903008 ! organelle disassembly created_by: pr creation_date: 2016-11-14T13:39:14Z [Term] id: GO:1905693 name: regulation of phosphatidic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] synonym: "regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006654 ! phosphatidic acid biosynthetic process relationship: regulates GO:0006654 ! phosphatidic acid biosynthetic process created_by: bc creation_date: 2016-11-14T14:48:09Z [Term] id: GO:1905694 name: negative regulation of phosphatidic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] synonym: "down regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of phosphatidic acid anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidic acid formation" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidic acid synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "negative regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006654 ! phosphatidic acid biosynthetic process relationship: negatively_regulates GO:0006654 ! phosphatidic acid biosynthetic process created_by: bc creation_date: 2016-11-14T14:48:16Z [Term] id: GO:1905695 name: positive regulation of phosphatidic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] synonym: "activation of phosphatidic acid anabolism" NARROW [GOC:TermGenie] synonym: "activation of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of phosphatidic acid formation" NARROW [GOC:TermGenie] synonym: "activation of phosphatidic acid synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "positive regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid formation" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006654 ! phosphatidic acid biosynthetic process relationship: positively_regulates GO:0006654 ! phosphatidic acid biosynthetic process created_by: bc creation_date: 2016-11-14T14:48:24Z [Term] id: GO:1905696 name: regulation of polysome binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "regulation of polyribosome binding" EXACT [GOC:TermGenie] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905538 ! polysome binding relationship: regulates GO:1905538 ! polysome binding created_by: bc creation_date: 2016-11-14T23:26:22Z [Term] id: GO:1905697 name: negative regulation of polysome binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "down regulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "down regulation of polysome binding" EXACT [GOC:TermGenie] synonym: "down-regulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "down-regulation of polysome binding" EXACT [GOC:TermGenie] synonym: "downregulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "downregulation of polysome binding" EXACT [GOC:TermGenie] synonym: "inhibition of polyribosome binding" NARROW [GOC:TermGenie] synonym: "inhibition of polysome binding" NARROW [GOC:TermGenie] synonym: "negative regulation of polyribosome binding" EXACT [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1905696 ! regulation of polysome binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905538 ! polysome binding relationship: negatively_regulates GO:1905538 ! polysome binding created_by: bc creation_date: 2016-11-14T23:26:29Z [Term] id: GO:1905698 name: positive regulation of polysome binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] synonym: "activation of polyribosome binding" NARROW [GOC:TermGenie] synonym: "activation of polysome binding" NARROW [GOC:TermGenie] synonym: "positive regulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "up regulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "up regulation of polysome binding" EXACT [GOC:TermGenie] synonym: "up-regulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "up-regulation of polysome binding" EXACT [GOC:TermGenie] synonym: "upregulation of polyribosome binding" EXACT [GOC:TermGenie] synonym: "upregulation of polysome binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1905696 ! regulation of polysome binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905538 ! polysome binding relationship: positively_regulates GO:1905538 ! polysome binding created_by: bc creation_date: 2016-11-14T23:26:37Z [Term] id: GO:1905699 name: regulation of xenobiotic detoxification by transmembrane export across the plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of drug transmembrane export." [GO_REF:0000058, GOC:TermGenie, PMID:15198509] comment: Changed term label as requested https://github.com/geneontology/go-ontology/issues/17083 synonym: "regulation of drug transmembrane export" NARROW [] synonym: "regulation of xenobiotic transmembrane export" NARROW [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane relationship: regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane created_by: sl creation_date: 2016-11-15T16:46:28Z [Term] id: GO:1905700 name: negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of drug transmembrane export." [GO_REF:0000058, GOC:TermGenie, PMID:15198509] comment: Changed term label as requested https://github.com/geneontology/go-ontology/issues/17083 synonym: "down regulation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "down-regulation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "downregulation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "inhibition of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "negative regulation of drug transmembrane export" NARROW [] synonym: "negative regulation of xenobiotic transmembrane export" NARROW [] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane relationship: negatively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane created_by: sl creation_date: 2016-11-15T16:46:36Z [Term] id: GO:1905701 name: positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of drug transmembrane export." [GO_REF:0000058, GOC:TermGenie, PMID:15198509] comment: Changed term label as requested https://github.com/geneontology/go-ontology/issues/17083 synonym: "activation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "positive regulation of drug transmembrane export" NARROW [] synonym: "positive regulation of xenobiotic transmembrane export" NARROW [] synonym: "up regulation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "up-regulation of drug transmembrane export" NARROW [GOC:TermGenie] synonym: "upregulation of drug transmembrane export" NARROW [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane relationship: positively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane created_by: sl creation_date: 2016-11-15T16:46:44Z [Term] id: GO:1905702 name: regulation of inhibitory synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904862 ! inhibitory synapse assembly relationship: regulates GO:1904862 ! inhibitory synapse assembly created_by: tb creation_date: 2016-11-16T18:55:32Z [Term] id: GO:1905703 name: negative regulation of inhibitory synapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "downregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "inhibition of inhibitory synapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of inhibitory synapse formation" NARROW [GOC:TermGenie] synonym: "negative regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1905702 ! regulation of inhibitory synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904862 ! inhibitory synapse assembly relationship: negatively_regulates GO:1904862 ! inhibitory synapse assembly created_by: tb creation_date: 2016-11-16T18:55:40Z [Term] id: GO:1905704 name: positive regulation of inhibitory synapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "activation of inhibitory synapse assembly" NARROW [GOC:TermGenie] synonym: "activation of inhibitory synapse formation" NARROW [GOC:TermGenie] synonym: "positive regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "up regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] synonym: "upregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of inhibitory synapse formation" EXACT [GOC:TermGenie] is_a: GO:0051965 ! positive regulation of synapse assembly is_a: GO:1905702 ! regulation of inhibitory synapse assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904862 ! inhibitory synapse assembly relationship: positively_regulates GO:1904862 ! inhibitory synapse assembly created_by: tb creation_date: 2016-11-16T18:55:49Z [Term] id: GO:1905705 name: cellular response to paclitaxel namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18472094] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901555 ! response to paclitaxel created_by: sl creation_date: 2016-11-16T21:40:32Z [Term] id: GO:1905706 name: regulation of mitochondrial ATP synthesis coupled proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] is_a: GO:0002082 ! regulation of oxidative phosphorylation is_a: GO:0010155 ! regulation of proton transport is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport relationship: regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport created_by: vw creation_date: 2016-11-17T14:07:33Z [Term] id: GO:1905707 name: negative regulation of mitochondrial ATP synthesis coupled proton transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0090324 ! negative regulation of oxidative phosphorylation is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905706 ! regulation of mitochondrial ATP synthesis coupled proton transport is_a: GO:2001170 ! negative regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport relationship: negatively_regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport created_by: vw creation_date: 2016-11-17T14:07:40Z [Term] id: GO:1905708 name: regulation of cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the location, frequency, rate or extent of cell morphogenesis involved in conjugation with cellular fusion." [GO_REF:0000058, GOC:TermGenie, PMID:23200991] synonym: "regulation of shmoo orientation" NARROW [GOC:TermGenie] synonym: "regulation of shmooing" NARROW [GOC:TermGenie] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0031137 ! regulation of conjugation with cellular fusion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion relationship: regulates GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion created_by: mah creation_date: 2016-11-18T11:33:54Z [Term] id: GO:1905709 name: negative regulation of membrane permeability namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] is_a: GO:0090559 ! regulation of membrane permeability created_by: hbye creation_date: 2016-11-18T13:10:42Z [Term] id: GO:1905710 name: positive regulation of membrane permeability namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] is_a: GO:0090559 ! regulation of membrane permeability created_by: hbye creation_date: 2016-11-18T13:10:53Z [Term] id: GO:1905711 name: response to phosphatidylethanolamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995] synonym: "response to PE" EXACT [] synonym: "response to phosphatidyl(amino)ethanols" EXACT [] synonym: "response to phosphatidylethanolamines" EXACT [] synonym: "response to PtdEtn" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2016-11-21T19:55:32Z [Term] id: GO:1905712 name: cellular response to phosphatidylethanolamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995] synonym: "cellular response to PE" EXACT [] synonym: "cellular response to phosphatidyl(amino)ethanols" EXACT [] synonym: "cellular response to phosphatidylethanolamines" EXACT [] synonym: "cellular response to PtdEtn" EXACT [] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905711 ! response to phosphatidylethanolamine created_by: sl creation_date: 2016-11-21T19:55:40Z [Term] id: GO:1905713 name: obsolete mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium ion concentration namespace: biological_process def: "OBSOLETE. Any mitochondrial calcium uptake that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] synonym: "mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2016-11-23T15:55:53Z [Term] id: GO:1905714 name: obsolete mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium ion concentration namespace: biological_process def: "OBSOLETE. Any mitochondrial calcium release that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] synonym: "mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] is_obsolete: true created_by: dos creation_date: 2016-11-23T15:56:01Z [Term] id: GO:1905715 name: regulation of cornification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045616 ! regulation of keratinocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070268 ! cornification relationship: regulates GO:0070268 ! cornification created_by: pga creation_date: 2016-11-24T13:52:55Z [Term] id: GO:1905716 name: negative regulation of cornification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] synonym: "down regulation of cornification" EXACT [GOC:TermGenie] synonym: "down-regulation of cornification" EXACT [GOC:TermGenie] synonym: "downregulation of cornification" EXACT [GOC:TermGenie] synonym: "inhibition of cornification" NARROW [GOC:TermGenie] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0045617 ! negative regulation of keratinocyte differentiation is_a: GO:1905715 ! regulation of cornification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070268 ! cornification relationship: negatively_regulates GO:0070268 ! cornification created_by: pga creation_date: 2016-11-24T13:53:03Z [Term] id: GO:1905717 name: positive regulation of cornification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] synonym: "activation of cornification" NARROW [GOC:TermGenie] synonym: "up regulation of cornification" EXACT [GOC:TermGenie] synonym: "up-regulation of cornification" EXACT [GOC:TermGenie] synonym: "upregulation of cornification" EXACT [GOC:TermGenie] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0045618 ! positive regulation of keratinocyte differentiation is_a: GO:1905715 ! regulation of cornification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070268 ! cornification relationship: positively_regulates GO:0070268 ! cornification created_by: pga creation_date: 2016-11-24T13:53:21Z [Term] id: GO:1905718 name: obsolete mitotic spindle astral microtubule end namespace: cellular_component def: "OBSOLETE. Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "mitotic spindle astral microtubule tip" EXACT [] is_obsolete: true created_by: vw creation_date: 2016-11-24T14:30:11Z [Term] id: GO:1905719 name: protein localization to perinuclear region of cytoplasm namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] synonym: "protein localisation in perinuclear region of cytoplasm" EXACT [GOC:TermGenie] synonym: "protein localisation to perinuclear region of cytoplasm" EXACT [GOC:TermGenie] synonym: "protein localization in perinuclear region of cytoplasm" EXACT [GOC:TermGenie] synonym: "protein localization to perinuclear cytoplasm" EXACT [] is_a: GO:0008104 ! protein localization created_by: mah creation_date: 2016-11-24T16:51:55Z [Term] id: GO:1905720 name: cytoplasmic microtubule bundle namespace: cellular_component def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie] is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm created_by: mah creation_date: 2016-11-24T16:52:02Z [Term] id: GO:1905721 name: mitotic spindle astral microtubule end namespace: cellular_component def: "Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] synonym: "mitotic spindle astral microtubule tip" EXACT [] is_a: GO:1990752 ! microtubule end intersection_of: GO:1990752 ! microtubule end intersection_of: part_of GO:0061673 ! mitotic spindle astral microtubule relationship: part_of GO:0061673 ! mitotic spindle astral microtubule created_by: vw creation_date: 2016-11-25T12:26:18Z [Term] id: GO:1905722 name: regulation of trypanothione biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] synonym: "regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "regulation of trypanothione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019342 ! trypanothione biosynthetic process relationship: regulates GO:0019342 ! trypanothione biosynthetic process created_by: rz creation_date: 2016-11-25T14:44:34Z [Term] id: GO:1905723 name: negative regulation of trypanothione biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] synonym: "down regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "down regulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "down-regulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "downregulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of trypanothione anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of trypanothione biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of trypanothione biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of trypanothione formation" NARROW [GOC:TermGenie] synonym: "inhibition of trypanothione synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "negative regulation of trypanothione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:1905722 ! regulation of trypanothione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019342 ! trypanothione biosynthetic process relationship: negatively_regulates GO:0019342 ! trypanothione biosynthetic process created_by: rz creation_date: 2016-11-25T14:44:42Z [Term] id: GO:1905724 name: positive regulation of trypanothione biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] synonym: "activation of trypanothione anabolism" NARROW [GOC:TermGenie] synonym: "activation of trypanothione biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of trypanothione biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of trypanothione formation" NARROW [GOC:TermGenie] synonym: "activation of trypanothione synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "positive regulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "up regulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "up-regulation of trypanothione synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of trypanothione anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of trypanothione formation" EXACT [GOC:TermGenie] synonym: "upregulation of trypanothione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:1905722 ! regulation of trypanothione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019342 ! trypanothione biosynthetic process relationship: positively_regulates GO:0019342 ! trypanothione biosynthetic process created_by: rz creation_date: 2016-11-25T14:44:50Z [Term] id: GO:1905725 name: protein localization to microtubule end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a microtubule end." [GO_REF:0000087, GOC:TermGenie, PMID:12034771] synonym: "protein localisation to microtubule end" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule created_by: mah creation_date: 2016-11-28T15:01:43Z [Term] id: GO:1905735 name: regulation of L-proline import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902834 ! regulation of proline import across plasma membrane is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904271 ! L-proline import across plasma membrane relationship: regulates GO:1904271 ! L-proline import across plasma membrane created_by: ValWood creation_date: 2016-12-04T20:42:16Z [Term] id: GO:1905736 name: negative regulation of L-proline import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902835 ! negative regulation of proline import across plasma membrane is_a: GO:1905735 ! regulation of L-proline import across plasma membrane is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904271 ! L-proline import across plasma membrane relationship: negatively_regulates GO:1904271 ! L-proline import across plasma membrane created_by: ValWood creation_date: 2016-12-04T20:42:24Z [Term] id: GO:1905737 name: positive regulation of L-proline import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902836 ! positive regulation of proline import across plasma membrane is_a: GO:1905735 ! regulation of L-proline import across plasma membrane is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904271 ! L-proline import across plasma membrane relationship: positively_regulates GO:1904271 ! L-proline import across plasma membrane created_by: ValWood creation_date: 2016-12-04T20:42:33Z [Term] id: GO:1905741 name: calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] synonym: "calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie] synonym: "mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [] is_a: GO:0099093 ! calcium export from the mitochondrion is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration intersection_of: GO:0099093 ! calcium export from the mitochondrion intersection_of: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration relationship: part_of GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration created_by: dosumis creation_date: 2016-12-06T10:05:01Z [Term] id: GO:1905742 name: Ras guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity." [GO_REF:0000088, GOC:rjd, GOC:TermGenie, PMID:20493808] is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex created_by: rjdodson creation_date: 2016-12-06T10:24:29Z [Term] id: GO:1905743 name: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration namespace: biological_process def: "Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] subset: goslim_synapse synonym: "calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie] synonym: "mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [] is_a: GO:0036444 ! calcium import into the mitochondrion is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0036444 ! calcium import into the mitochondrion intersection_of: part_of GO:0099113 ! negative regulation of presynaptic cytosolic calcium concentration relationship: part_of GO:0099113 ! negative regulation of presynaptic cytosolic calcium concentration created_by: dosumis creation_date: 2016-12-06T10:53:17Z [Term] id: GO:1905744 name: regulation of mRNA cis splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] synonym: "regulation of nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:TermGenie] synonym: "regulation of nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [GOC:TermGenie] synonym: "regulation of splicing" BROAD [GOC:TermGenie] is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045292 ! mRNA cis splicing, via spliceosome relationship: regulates GO:0045292 ! mRNA cis splicing, via spliceosome created_by: ValWood creation_date: 2016-12-07T14:01:33Z [Term] id: GO:1905745 name: negative regulation of mRNA cis splicing, via spliceosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] is_a: GO:0048025 ! negative regulation of mRNA splicing, via spliceosome is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome relationship: negatively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome created_by: ValWood creation_date: 2016-12-07T14:01:42Z [Term] id: GO:1905746 name: positive regulation of mRNA cis splicing, via spliceosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] is_a: GO:0048026 ! positive regulation of mRNA splicing, via spliceosome is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome relationship: positively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome created_by: ValWood creation_date: 2016-12-07T14:01:52Z [Term] id: GO:1905747 name: negative regulation of saliva secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." [GO_REF:0000058, GOC:TermGenie, PMID:23419067] synonym: "down regulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "down regulation of salivation" EXACT [GOC:TermGenie] synonym: "down-regulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of salivation" EXACT [GOC:TermGenie] synonym: "downregulation of saliva secretion" EXACT [GOC:TermGenie] synonym: "downregulation of salivation" EXACT [GOC:TermGenie] synonym: "inhibition of saliva secretion" NARROW [GOC:TermGenie] synonym: "inhibition of salivation" NARROW [GOC:TermGenie] synonym: "negative regulation of salivation" EXACT [GOC:TermGenie] is_a: GO:0046877 ! regulation of saliva secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0060457 ! negative regulation of digestive system process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046541 ! saliva secretion relationship: negatively_regulates GO:0046541 ! saliva secretion created_by: pgarmiri creation_date: 2016-12-09T10:24:00Z [Term] id: GO:1905748 name: hard palate morphogenesis namespace: biological_process def: "The developmental process by which a hard palate is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:23419067] synonym: "palatum durum morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis created_by: pgarmiri creation_date: 2016-12-09T12:22:24Z [Term] id: GO:1905749 name: regulation of endosome to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0099638 ! endosome to plasma membrane protein transport relationship: regulates GO:0099638 ! endosome to plasma membrane protein transport created_by: pgarmiri creation_date: 2016-12-09T13:46:13Z [Term] id: GO:1905750 name: negative regulation of endosome to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] synonym: "down regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] synonym: "down-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] synonym: "downregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] synonym: "inhibition of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie] is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0099638 ! endosome to plasma membrane protein transport relationship: negatively_regulates GO:0099638 ! endosome to plasma membrane protein transport created_by: pgarmiri creation_date: 2016-12-09T13:46:21Z [Term] id: GO:1905751 name: positive regulation of endosome to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] synonym: "activation of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie] synonym: "up regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] synonym: "up-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] synonym: "upregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0099638 ! endosome to plasma membrane protein transport relationship: positively_regulates GO:0099638 ! endosome to plasma membrane protein transport created_by: pgarmiri creation_date: 2016-12-09T13:46:30Z [Term] id: GO:1905752 name: regulation of argininosuccinate synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403] synonym: "regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] synonym: "regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004055 ! argininosuccinate synthase activity relationship: regulates GO:0004055 ! argininosuccinate synthase activity created_by: dosumis creation_date: 2016-12-12T11:43:52Z [Term] id: GO:1905753 name: positive regulation of argininosuccinate synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403] synonym: "activation of arginine succinate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of argininosuccinate synthase activity" NARROW [GOC:TermGenie] synonym: "activation of argininosuccinate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of argininosuccinic acid synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of arginosuccinate synthetase activity" NARROW [GOC:TermGenie] synonym: "activation of citrulline--aspartate ligase activity" NARROW [GOC:TermGenie] synonym: "activation of L-citrulline:L-aspartate ligase (AMP-forming)" NARROW [GOC:TermGenie] synonym: "positive regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] synonym: "up regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] synonym: "up regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "up-regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] synonym: "upregulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] synonym: "upregulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] synonym: "upregulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] synonym: "upregulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:1905752 ! regulation of argininosuccinate synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004055 ! argininosuccinate synthase activity relationship: positively_regulates GO:0004055 ! argininosuccinate synthase activity created_by: dosumis creation_date: 2016-12-12T11:44:09Z [Term] id: GO:1905754 name: ascospore-type prospore nucleus namespace: cellular_component def: "Any nucleus that is part of a ascospore-type prospore." [GO_REF:0000064, GOC:TermGenie, PMID:26942678] synonym: "cell nucleus of ascospore-type prospore" EXACT [GOC:TermGenie] synonym: "nucleus of ascospore-type prospore" EXACT [GOC:TermGenie] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: part_of GO:0042764 ! ascospore-type prospore relationship: part_of GO:0042764 ! ascospore-type prospore created_by: Antonialock creation_date: 2016-12-12T13:25:00Z [Term] id: GO:1905755 name: protein localization to cytoplasmic microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule created_by: mah11 creation_date: 2016-12-12T15:31:07Z [Term] id: GO:1905756 name: regulation of primary cell septum biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] is_a: GO:0140279 ! regulation of mitotic division septum assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031671 ! primary cell septum biogenesis relationship: regulates GO:0031671 ! primary cell septum biogenesis created_by: ValWood creation_date: 2016-12-12T18:09:50Z [Term] id: GO:1905757 name: negative regulation of primary cell septum biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] is_a: GO:0140280 ! negative regulation of mitotic division septum assembly is_a: GO:1905756 ! regulation of primary cell septum biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031671 ! primary cell septum biogenesis relationship: negatively_regulates GO:0031671 ! primary cell septum biogenesis created_by: ValWood creation_date: 2016-12-12T18:09:59Z [Term] id: GO:1905758 name: positive regulation of primary cell septum biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] is_a: GO:0140281 ! positive regulation of mitotic division septum assembly is_a: GO:1905756 ! regulation of primary cell septum biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031671 ! primary cell septum biogenesis relationship: positively_regulates GO:0031671 ! primary cell septum biogenesis created_by: ValWood creation_date: 2016-12-12T18:10:07Z [Term] id: GO:1905759 name: post-anaphase array microtubule namespace: cellular_component def: "Any microtubule that is part of a post-anaphase microtubule array." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] synonym: "microtubule of PAA" EXACT [GOC:TermGenie] synonym: "microtubule of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "microtubuli of PAA" EXACT [GOC:TermGenie] synonym: "microtubuli of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "microtubulus of PAA" EXACT [GOC:TermGenie] synonym: "microtubulus of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "neurotubule of PAA" NARROW [GOC:TermGenie] synonym: "neurotubule of post-anaphase array" NARROW [GOC:TermGenie] synonym: "neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:1990295 ! post-anaphase microtubule array relationship: part_of GO:1990295 ! post-anaphase microtubule array created_by: dosumis creation_date: 2016-12-12T18:36:53Z [Term] id: GO:1905760 name: post-anaphase array microtubule end namespace: cellular_component def: "Any microtubule end that is part of a post-anaphase array microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] synonym: "microtubule end of microtubule of PAA" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubule of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubuli of PAA" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubuli of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubulus of PAA" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubulus of post-anaphase array" EXACT [GOC:TermGenie] synonym: "microtubule end of microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie] synonym: "microtubule end of neurotubule of PAA" NARROW [GOC:TermGenie] synonym: "microtubule end of neurotubule of post-anaphase array" NARROW [GOC:TermGenie] synonym: "microtubule end of neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie] synonym: "microtubule end of post-anaphase array microtubule" EXACT [GOC:TermGenie] is_a: GO:1990752 ! microtubule end intersection_of: GO:1990752 ! microtubule end intersection_of: part_of GO:1905759 ! post-anaphase array microtubule relationship: part_of GO:1905759 ! post-anaphase array microtubule created_by: dosumis creation_date: 2016-12-12T19:38:32Z [Term] id: GO:1905761 name: SCF ubiquitin ligase complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SCF ubiquitin ligase complex." [GO_REF:000102, GOC:dph, GOC:ha, GOC:TermGenie, PMID:19723762] synonym: "CDL1 complex binding" EXACT [GOC:TermGenie] synonym: "CRL1 complex binding" EXACT [GOC:TermGenie] synonym: "Cul1-RING ubiquitin ligase complex binding" EXACT [GOC:TermGenie] synonym: "cullin-RING ligase 1 binding" EXACT [GOC:TermGenie] synonym: "SCF complex binding" EXACT [GOC:TermGenie] synonym: "SCF complex substrate recognition subunit binding" NARROW [GOC:TermGenie] synonym: "Skp1/Cul1/F-box protein complex binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: ukemi creation_date: 2016-12-14T15:08:12Z [Term] id: GO:1905762 name: CCR4-NOT complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR4-NOT complex." [GO_REF:000102, GOC:TermGenie, PMID:26942678] is_a: GO:0044877 ! protein-containing complex binding created_by: mah11 creation_date: 2016-12-15T15:48:53Z [Term] id: GO:1905763 name: MTREC complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a MTREC complex." [GO_REF:000102, GOC:TermGenie, PMID:26942678] synonym: "Mtl1-Red1 core complex binding" EXACT [GOC:TermGenie] is_a: GO:0044877 ! protein-containing complex binding created_by: mah11 creation_date: 2016-12-15T15:49:02Z [Term] id: GO:1905764 name: regulation of protection from non-homologous end joining at telomere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] synonym: "regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] is_a: GO:1904353 ! regulation of telomere capping is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031848 ! protection from non-homologous end joining at telomere relationship: regulates GO:0031848 ! protection from non-homologous end joining at telomere created_by: NancyCampbell creation_date: 2016-12-20T11:28:21Z [Term] id: GO:1905765 name: negative regulation of protection from non-homologous end joining at telomere namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] synonym: "down regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "down regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] synonym: "down-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "down-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] synonym: "downregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "downregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] synonym: "inhibition of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie] synonym: "inhibition of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie] synonym: "negative regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] is_a: GO:1904354 ! negative regulation of telomere capping is_a: GO:1904506 ! negative regulation of telomere maintenance in response to DNA damage is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031848 ! protection from non-homologous end joining at telomere relationship: negatively_regulates GO:0031848 ! protection from non-homologous end joining at telomere created_by: NancyCampbell creation_date: 2016-12-20T11:28:30Z [Term] id: GO:1905766 name: positive regulation of protection from non-homologous end joining at telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] synonym: "activation of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie] synonym: "activation of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie] synonym: "positive regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "up regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "up regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] synonym: "up-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "up-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] synonym: "upregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] synonym: "upregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] is_a: GO:1904355 ! positive regulation of telomere capping is_a: GO:1904507 ! positive regulation of telomere maintenance in response to DNA damage is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031848 ! protection from non-homologous end joining at telomere relationship: positively_regulates GO:0031848 ! protection from non-homologous end joining at telomere created_by: NancyCampbell creation_date: 2016-12-20T11:28:39Z [Term] id: GO:1905767 name: regulation of double-stranded telomeric DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] is_a: GO:1904742 ! regulation of telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003691 ! double-stranded telomeric DNA binding relationship: regulates GO:0003691 ! double-stranded telomeric DNA binding created_by: NancyCampbell creation_date: 2016-12-20T15:33:58Z [Term] id: GO:1905768 name: negative regulation of double-stranded telomeric DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] synonym: "down regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "down-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "downregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "inhibition of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie] is_a: GO:1904743 ! negative regulation of telomeric DNA binding is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003691 ! double-stranded telomeric DNA binding relationship: negatively_regulates GO:0003691 ! double-stranded telomeric DNA binding created_by: NancyCampbell creation_date: 2016-12-20T15:34:07Z [Term] id: GO:1905769 name: positive regulation of double-stranded telomeric DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] synonym: "activation of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] is_a: GO:1904744 ! positive regulation of telomeric DNA binding is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003691 ! double-stranded telomeric DNA binding relationship: positively_regulates GO:0003691 ! double-stranded telomeric DNA binding created_by: NancyCampbell creation_date: 2016-12-20T15:34:15Z [Term] id: GO:1905770 name: regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1905902 ! regulation of mesoderm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048333 ! mesodermal cell differentiation relationship: regulates GO:0048333 ! mesodermal cell differentiation created_by: rachhuntley creation_date: 2016-12-21T12:44:13Z [Term] id: GO:1905771 name: negative regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation is_a: GO:1905903 ! negative regulation of mesoderm formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048333 ! mesodermal cell differentiation relationship: negatively_regulates GO:0048333 ! mesodermal cell differentiation created_by: rachhuntley creation_date: 2016-12-21T12:44:23Z [Term] id: GO:1905772 name: positive regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation is_a: GO:1905904 ! positive regulation of mesoderm formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048333 ! mesodermal cell differentiation relationship: positively_regulates GO:0048333 ! mesodermal cell differentiation created_by: rachhuntley creation_date: 2016-12-21T12:44:32Z [Term] id: GO:1905773 name: 8-hydroxy-2'-deoxyguanosine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA." [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539] is_a: GO:0032357 ! oxidized purine DNA binding created_by: NancyCampbell creation_date: 2016-12-21T15:57:27Z [Term] id: GO:1905774 name: regulation of DNA helicase activity namespace: biological_process alt_id: GO:1902449 def: "Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] synonym: "regulation of ATP-dependent DNA helicase activity" EXACT [] is_a: GO:0051095 ! regulation of helicase activity is_a: GO:1905462 ! regulation of DNA duplex unwinding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003678 ! DNA helicase activity relationship: regulates GO:0003678 ! DNA helicase activity created_by: rb creation_date: 2013-10-15T21:19:52Z [Term] id: GO:1905775 name: negative regulation of DNA helicase activity namespace: biological_process alt_id: GO:1902450 def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] synonym: "down regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "down regulation of DNA helicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA helicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "downregulation of DNA helicase activity" EXACT [GOC:TermGenie] synonym: "inhibition of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie] synonym: "inhibition of DNA helicase activity" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP-dependent DNA helicase activity" EXACT [] is_a: GO:0051097 ! negative regulation of helicase activity is_a: GO:1905463 ! negative regulation of DNA duplex unwinding is_a: GO:1905774 ! regulation of DNA helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003678 ! DNA helicase activity relationship: negatively_regulates GO:0003678 ! DNA helicase activity created_by: rb creation_date: 2013-10-15T21:20:01Z [Term] id: GO:1905776 name: positive regulation of DNA helicase activity namespace: biological_process alt_id: GO:1902451 def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] synonym: "activation of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie] synonym: "activation of DNA helicase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of ATP-dependent DNA helicase activity" EXACT [] synonym: "up regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA helicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA helicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA helicase activity" EXACT [GOC:TermGenie] is_a: GO:0051096 ! positive regulation of helicase activity is_a: GO:1905464 ! positive regulation of DNA duplex unwinding is_a: GO:1905774 ! regulation of DNA helicase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003678 ! DNA helicase activity relationship: positively_regulates GO:0003678 ! DNA helicase activity created_by: rb creation_date: 2013-10-15T21:20:10Z [Term] id: GO:1905777 name: regulation of exonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] synonym: "regulation of exonuclease IX activity" NARROW [GOC:TermGenie] is_a: GO:0032069 ! regulation of nuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004527 ! exonuclease activity relationship: regulates GO:0004527 ! exonuclease activity created_by: NancyCampbell creation_date: 2016-12-21T21:32:07Z [Term] id: GO:1905778 name: negative regulation of exonuclease activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] synonym: "down regulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "down regulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "down-regulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "down-regulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "downregulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "downregulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "inhibition of exonuclease activity" NARROW [GOC:TermGenie] synonym: "inhibition of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "negative regulation of exonuclease IX activity" NARROW [GOC:TermGenie] is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:1905777 ! regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004527 ! exonuclease activity relationship: negatively_regulates GO:0004527 ! exonuclease activity created_by: NancyCampbell creation_date: 2016-12-21T21:32:16Z [Term] id: GO:1905779 name: positive regulation of exonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] synonym: "activation of exonuclease activity" NARROW [GOC:TermGenie] synonym: "activation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "positive regulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "up regulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "up regulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "up-regulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "up-regulation of exonuclease IX activity" NARROW [GOC:TermGenie] synonym: "upregulation of exonuclease activity" EXACT [GOC:TermGenie] synonym: "upregulation of exonuclease IX activity" NARROW [GOC:TermGenie] is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:1905777 ! regulation of exonuclease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004527 ! exonuclease activity relationship: positively_regulates GO:0004527 ! exonuclease activity created_by: NancyCampbell creation_date: 2016-12-21T21:32:24Z [Term] id: GO:1905780 name: regulation of phosphatidylserine exposure on apoptotic cell surface namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] synonym: "regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] is_a: GO:0061091 ! regulation of phospholipid translocation is_a: GO:1900117 ! regulation of execution phase of apoptosis is_a: GO:1903729 ! regulation of plasma membrane organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface relationship: regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface created_by: vanaukenk creation_date: 2017-01-04T15:18:52Z [Term] id: GO:1905781 name: negative regulation of phosphatidylserine exposure on apoptotic cell surface namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] synonym: "down regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "down regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] synonym: "down-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "down-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] synonym: "downregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "downregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] synonym: "inhibition of externalization of phosphatidylserine" NARROW [GOC:TermGenie] synonym: "inhibition of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie] synonym: "negative regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] is_a: GO:0061093 ! negative regulation of phospholipid translocation is_a: GO:1900118 ! negative regulation of execution phase of apoptosis is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface relationship: negatively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface created_by: vanaukenk creation_date: 2017-01-04T15:19:14Z [Term] id: GO:1905782 name: positive regulation of phosphatidylserine exposure on apoptotic cell surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] synonym: "activation of externalization of phosphatidylserine" NARROW [GOC:TermGenie] synonym: "activation of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie] synonym: "positive regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "up regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "up regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] synonym: "up-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "up-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] synonym: "upregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] synonym: "upregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] is_a: GO:0061092 ! positive regulation of phospholipid translocation is_a: GO:1900119 ! positive regulation of execution phase of apoptosis is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface relationship: positively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface created_by: vanaukenk creation_date: 2017-01-04T15:19:22Z [Term] id: GO:1905783 name: CENP-A containing nucleosome disassembly namespace: biological_process def: "The disaggregation of a CENP-A containing nucleosome into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27666591] synonym: "centromere specific nucleosome disassembly" RELATED [GOC:TermGenie] synonym: "centromere-specific nucleosome disassembly" RELATED [GOC:TermGenie] synonym: "centromeric nucleosome disassembly" RELATED [GOC:TermGenie] is_a: GO:0006337 ! nucleosome disassembly created_by: ValWood creation_date: 2017-01-05T09:19:07Z [Term] id: GO:1905784 name: regulation of anaphase-promoting complex-dependent catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process relationship: regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process created_by: ValWood creation_date: 2017-01-09T10:16:14Z [Term] id: GO:1905785 name: negative regulation of anaphase-promoting complex-dependent catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process created_by: ValWood creation_date: 2017-01-09T10:16:23Z [Term] id: GO:1905786 name: positive regulation of anaphase-promoting complex-dependent catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process created_by: ValWood creation_date: 2017-01-09T10:16:33Z [Term] id: GO:1905787 name: regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch relationship: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch created_by: hbye creation_date: 2017-01-09T15:11:04Z [Term] id: GO:1905788 name: negative regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "down regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "down-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "downregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "inhibition of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "negative regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "negative regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch relationship: negatively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch created_by: hbye creation_date: 2017-01-09T15:11:14Z [Term] id: GO:1905789 name: positive regulation of detection of mechanical stimulus involved in sensory perception of touch namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "activation of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "activation of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] synonym: "activation of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "positive regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "positive regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "up-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] synonym: "upregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch relationship: positively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch created_by: hbye creation_date: 2017-01-09T15:11:23Z [Term] id: GO:1905790 name: regulation of mechanosensory behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007638 ! mechanosensory behavior relationship: regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:07Z [Term] id: GO:1905791 name: negative regulation of mechanosensory behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "down regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "down regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "down-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "down-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "downregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "downregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "inhibition of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of mechanosensory behavior" NARROW [GOC:TermGenie] synonym: "inhibition of mechanosensory behaviour" NARROW [GOC:TermGenie] synonym: "negative regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "negative regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1905790 ! regulation of mechanosensory behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007638 ! mechanosensory behavior relationship: negatively_regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:15Z [Term] id: GO:1905792 name: positive regulation of mechanosensory behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] synonym: "activation of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] synonym: "activation of mechanosensory behavior" NARROW [GOC:TermGenie] synonym: "activation of mechanosensory behaviour" NARROW [GOC:TermGenie] synonym: "positive regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "positive regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "up regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "up regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "up-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "up-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] synonym: "upregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of mechanosensory behavior" EXACT [GOC:TermGenie] synonym: "upregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1905790 ! regulation of mechanosensory behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007638 ! mechanosensory behavior relationship: positively_regulates GO:0007638 ! mechanosensory behavior created_by: hbye creation_date: 2017-01-09T15:17:24Z [Term] id: GO:1905793 name: protein localization to pericentriolar material namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a pericentriolar material." [GO_REF:0000087, GOC:TermGenie, PMID:21694707, PMID:24385583] synonym: "protein localisation in pericentriolar material" EXACT [GOC:TermGenie] synonym: "protein localisation to pericentriolar material" EXACT [GOC:TermGenie] synonym: "protein localization in pericentriolar material" EXACT [GOC:TermGenie] is_a: GO:0071539 ! protein localization to centrosome created_by: hattrill creation_date: 2017-01-10T11:10:37Z [Term] id: GO:1905794 name: response to puromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] synonym: "response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046677 ! response to antibiotic is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: slaulederkind creation_date: 2017-01-10T21:13:18Z [Term] id: GO:1905795 name: cellular response to puromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] synonym: "cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] is_a: GO:0035690 ! cellular response to drug is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905794 ! response to puromycin created_by: slaulederkind creation_date: 2017-01-10T21:13:28Z [Term] id: GO:1905796 name: regulation of intraciliary anterograde transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035720 ! intraciliary anterograde transport relationship: regulates GO:0035720 ! intraciliary anterograde transport created_by: hbye creation_date: 2017-01-11T12:55:35Z [Term] id: GO:1905797 name: negative regulation of intraciliary anterograde transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "down regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "down regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "down-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "down-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "downregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "downregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "inhibition of intraciliary anterograde transport" NARROW [GOC:TermGenie] synonym: "inhibition of intraflagellar anterograde transport" NARROW [GOC:TermGenie] synonym: "negative regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905796 ! regulation of intraciliary anterograde transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035720 ! intraciliary anterograde transport relationship: negatively_regulates GO:0035720 ! intraciliary anterograde transport created_by: hbye creation_date: 2017-01-11T12:55:53Z [Term] id: GO:1905798 name: positive regulation of intraciliary anterograde transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "activation of intraciliary anterograde transport" NARROW [GOC:TermGenie] synonym: "activation of intraflagellar anterograde transport" NARROW [GOC:TermGenie] synonym: "positive regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "up regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "up regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "up-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "up-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] synonym: "upregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] synonym: "upregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905796 ! regulation of intraciliary anterograde transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035720 ! intraciliary anterograde transport relationship: positively_regulates GO:0035720 ! intraciliary anterograde transport created_by: hbye creation_date: 2017-01-11T12:56:01Z [Term] id: GO:1905799 name: regulation of intraciliary retrograde transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035721 ! intraciliary retrograde transport relationship: regulates GO:0035721 ! intraciliary retrograde transport created_by: hbye creation_date: 2017-01-11T12:58:18Z [Term] id: GO:1905800 name: negative regulation of intraciliary retrograde transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "down regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "down regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "down-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "down-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "downregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "downregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "inhibition of intraciliary retrograde transport" NARROW [GOC:TermGenie] synonym: "inhibition of intraflagellar retrograde transport" NARROW [GOC:TermGenie] synonym: "negative regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905799 ! regulation of intraciliary retrograde transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035721 ! intraciliary retrograde transport relationship: negatively_regulates GO:0035721 ! intraciliary retrograde transport created_by: hbye creation_date: 2017-01-11T12:58:26Z [Term] id: GO:1905801 name: positive regulation of intraciliary retrograde transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] synonym: "activation of intraciliary retrograde transport" NARROW [GOC:TermGenie] synonym: "activation of intraflagellar retrograde transport" NARROW [GOC:TermGenie] synonym: "positive regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "up regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "up regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "up-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "up-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] synonym: "upregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] synonym: "upregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905799 ! regulation of intraciliary retrograde transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035721 ! intraciliary retrograde transport relationship: positively_regulates GO:0035721 ! intraciliary retrograde transport created_by: hbye creation_date: 2017-01-11T12:58:35Z [Term] id: GO:1905802 name: regulation of cellular response to manganese ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] synonym: "regulation of cellular response to manganese" EXACT [GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071287 ! cellular response to manganese ion relationship: regulates GO:0071287 ! cellular response to manganese ion created_by: pgarmiri creation_date: 2017-01-11T14:59:39Z [Term] id: GO:1905803 name: negative regulation of cellular response to manganese ion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] synonym: "down regulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to manganese ion" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to manganese" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to manganese ion" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to manganese" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905802 ! regulation of cellular response to manganese ion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071287 ! cellular response to manganese ion relationship: negatively_regulates GO:0071287 ! cellular response to manganese ion created_by: pgarmiri creation_date: 2017-01-11T14:59:48Z [Term] id: GO:1905804 name: positive regulation of cellular response to manganese ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] synonym: "activation of cellular response to manganese" NARROW [GOC:TermGenie] synonym: "activation of cellular response to manganese ion" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to manganese" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to manganese ion" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905802 ! regulation of cellular response to manganese ion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071287 ! cellular response to manganese ion relationship: positively_regulates GO:0071287 ! cellular response to manganese ion created_by: pgarmiri creation_date: 2017-01-11T14:59:57Z [Term] id: GO:1905805 name: excitatory synapse pruning namespace: biological_process def: "The disaggregation of an excitatory synapse into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27779093] synonym: "synapse clearance" BROAD [] synonym: "synapse disassembly" BROAD [] synonym: "synapse elimination" BROAD [] synonym: "synapse removal" BROAD [] is_a: GO:0098883 ! synapse pruning created_by: tberardini creation_date: 2017-01-11T22:03:06Z [Term] id: GO:1905806 name: regulation of synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] subset: goslim_synapse synonym: "regulation of synapse clearance" EXACT [] synonym: "regulation of synapse disassembly" EXACT syngo_official_label [] synonym: "regulation of synapse elimination" EXACT [] synonym: "regulation of synapse removal" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098883 ! synapse pruning relationship: regulates GO:0098883 ! synapse pruning created_by: tberardini creation_date: 2017-01-11T22:03:15Z [Term] id: GO:1905807 name: negative regulation of synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098883 ! synapse pruning relationship: negatively_regulates GO:0098883 ! synapse pruning created_by: tberardini creation_date: 2017-01-11T22:03:24Z [Term] id: GO:1905808 name: positive regulation of synapse pruning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098883 ! synapse pruning relationship: positively_regulates GO:0098883 ! synapse pruning created_by: tberardini creation_date: 2017-01-11T22:03:33Z [Term] id: GO:1905809 name: negative regulation of synapse organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse development" EXACT [GOC:TermGenie] synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse development" NARROW [GOC:TermGenie] synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050808 ! synapse organization relationship: negatively_regulates GO:0050808 ! synapse organization created_by: tberardini creation_date: 2017-01-11T22:03:41Z [Term] id: GO:1905810 name: regulation of excitatory synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905805 ! excitatory synapse pruning relationship: regulates GO:1905805 ! excitatory synapse pruning created_by: tberardini creation_date: 2017-01-12T02:38:27Z [Term] id: GO:1905811 name: negative regulation of excitatory synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of excitatory synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905807 ! negative regulation of synapse pruning is_a: GO:1905810 ! regulation of excitatory synapse pruning intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905805 ! excitatory synapse pruning relationship: negatively_regulates GO:1905805 ! excitatory synapse pruning created_by: tberardini creation_date: 2017-01-12T02:38:36Z [Term] id: GO:1905812 name: regulation of motor neuron axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "regulation of motor axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008045 ! motor neuron axon guidance relationship: regulates GO:0008045 ! motor neuron axon guidance created_by: hbye creation_date: 2017-01-12T13:25:12Z [Term] id: GO:1905813 name: negative regulation of motor neuron axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "down regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "down regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "down-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "downregulation of motor neuron axon guidance" EXACT [GOC:TermGenie] synonym: "inhibition of motoneuron axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of motor axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of motor axon pathfinding" NARROW [GOC:TermGenie] synonym: "inhibition of motor neuron axon guidance" NARROW [GOC:TermGenie] synonym: "negative regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "negative regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "negative regulation of motor axon pathfinding" EXACT [GOC:TermGenie] is_a: GO:1902668 ! negative regulation of axon guidance is_a: GO:1905812 ! regulation of motor neuron axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008045 ! motor neuron axon guidance relationship: negatively_regulates GO:0008045 ! motor neuron axon guidance created_by: hbye creation_date: 2017-01-12T13:25:21Z [Term] id: GO:1905814 name: positive regulation of motor neuron axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "activation of motoneuron axon guidance" NARROW [GOC:TermGenie] synonym: "activation of motor axon guidance" NARROW [GOC:TermGenie] synonym: "activation of motor axon pathfinding" NARROW [GOC:TermGenie] synonym: "activation of motor neuron axon guidance" NARROW [GOC:TermGenie] synonym: "positive regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "positive regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "positive regulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of motoneuron axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of motor axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of motor axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of motor neuron axon guidance" EXACT [GOC:TermGenie] is_a: GO:1902669 ! positive regulation of axon guidance is_a: GO:1905812 ! regulation of motor neuron axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008045 ! motor neuron axon guidance relationship: positively_regulates GO:0008045 ! motor neuron axon guidance created_by: hbye creation_date: 2017-01-12T13:25:31Z [Term] id: GO:1905815 name: regulation of dorsal/ventral axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033563 ! dorsal/ventral axon guidance relationship: regulates GO:0033563 ! dorsal/ventral axon guidance created_by: hbye creation_date: 2017-01-12T13:38:44Z [Term] id: GO:1905816 name: negative regulation of dorsal/ventral axon guidance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "down regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "down regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "down regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "down-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "down-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "downregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "downregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "inhibition of dorsal-ventral axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of dorsal/ventral axon guidance" NARROW [GOC:TermGenie] synonym: "inhibition of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie] synonym: "inhibition of dorsoventral axon guidance" NARROW [GOC:TermGenie] synonym: "negative regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "negative regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "negative regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] is_a: GO:1902668 ! negative regulation of axon guidance is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033563 ! dorsal/ventral axon guidance relationship: negatively_regulates GO:0033563 ! dorsal/ventral axon guidance created_by: hbye creation_date: 2017-01-12T13:38:53Z [Term] id: GO:1905817 name: positive regulation of dorsal/ventral axon guidance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] synonym: "activation of dorsal-ventral axon guidance" NARROW [GOC:TermGenie] synonym: "activation of dorsal/ventral axon guidance" NARROW [GOC:TermGenie] synonym: "activation of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie] synonym: "activation of dorsoventral axon guidance" NARROW [GOC:TermGenie] synonym: "positive regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "positive regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "positive regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "up regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "up regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "up-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "up-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] synonym: "upregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] is_a: GO:1902669 ! positive regulation of axon guidance is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033563 ! dorsal/ventral axon guidance relationship: positively_regulates GO:0033563 ! dorsal/ventral axon guidance created_by: hbye creation_date: 2017-01-12T13:39:01Z [Term] id: GO:1905818 name: regulation of chromosome separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] synonym: "regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "regulation of rDNA separation" NARROW [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051304 ! chromosome separation relationship: regulates GO:0051304 ! chromosome separation created_by: bmeldal creation_date: 2017-01-13T13:55:18Z [Term] id: GO:1905819 name: negative regulation of chromosome separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] synonym: "down regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "down regulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "down regulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "down-regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "down-regulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "down-regulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "downregulation of chromatid release" RELATED [GOC:TermGenie] synonym: "downregulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "downregulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatid release" RELATED [GOC:TermGenie] synonym: "inhibition of chromosome separation" NARROW [GOC:TermGenie] synonym: "inhibition of rDNA separation" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "negative regulation of rDNA separation" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:1905818 ! regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051304 ! chromosome separation relationship: negatively_regulates GO:0051304 ! chromosome separation created_by: bmeldal creation_date: 2017-01-13T13:55:27Z [Term] id: GO:1905820 name: positive regulation of chromosome separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] synonym: "activation of chromatid release" RELATED [GOC:TermGenie] synonym: "activation of chromosome separation" NARROW [GOC:TermGenie] synonym: "activation of rDNA separation" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "positive regulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "up regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "up regulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "up regulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "up-regulation of chromatid release" RELATED [GOC:TermGenie] synonym: "up-regulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "up-regulation of rDNA separation" NARROW [GOC:TermGenie] synonym: "upregulation of chromatid release" RELATED [GOC:TermGenie] synonym: "upregulation of chromosome separation" EXACT [GOC:TermGenie] synonym: "upregulation of rDNA separation" NARROW [GOC:TermGenie] is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1905818 ! regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051304 ! chromosome separation relationship: positively_regulates GO:0051304 ! chromosome separation created_by: bmeldal creation_date: 2017-01-13T13:55:36Z [Term] id: GO:1905821 name: positive regulation of chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030261 ! chromosome condensation relationship: positively_regulates GO:0030261 ! chromosome condensation created_by: bmeldal creation_date: 2017-01-13T14:13:44Z [Term] id: GO:1905822 name: regulation of mitotic sister chromatid arm separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990891 ! mitotic sister chromatid arm separation relationship: regulates GO:1990891 ! mitotic sister chromatid arm separation created_by: zebrafishembryo creation_date: 2017-01-16T13:36:29Z [Term] id: GO:1905823 name: negative regulation of mitotic sister chromatid arm separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] synonym: "down regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie] is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990891 ! mitotic sister chromatid arm separation relationship: negatively_regulates GO:1990891 ! mitotic sister chromatid arm separation created_by: zebrafishembryo creation_date: 2017-01-16T13:36:38Z [Term] id: GO:1905824 name: positive regulation of mitotic sister chromatid arm separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] synonym: "activation of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990891 ! mitotic sister chromatid arm separation relationship: positively_regulates GO:1990891 ! mitotic sister chromatid arm separation created_by: zebrafishembryo creation_date: 2017-01-16T13:36:47Z [Term] id: GO:1905825 name: regulation of selenocysteine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] synonym: "regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016259 ! selenocysteine metabolic process relationship: regulates GO:0016259 ! selenocysteine metabolic process created_by: slaulederkind creation_date: 2017-01-16T19:01:34Z [Term] id: GO:1905826 name: negative regulation of selenocysteine metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] synonym: "down regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of selenocysteine metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of selenocysteine metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:1905825 ! regulation of selenocysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016259 ! selenocysteine metabolic process relationship: negatively_regulates GO:0016259 ! selenocysteine metabolic process created_by: slaulederkind creation_date: 2017-01-16T19:01:42Z [Term] id: GO:1905827 name: positive regulation of selenocysteine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] synonym: "activation of selenocysteine metabolic process" NARROW [GOC:TermGenie] synonym: "activation of selenocysteine metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of selenocysteine metabolism" EXACT [GOC:TermGenie] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:1905825 ! regulation of selenocysteine metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016259 ! selenocysteine metabolic process relationship: positively_regulates GO:0016259 ! selenocysteine metabolic process created_by: slaulederkind creation_date: 2017-01-16T19:01:50Z [Term] id: GO:1905828 name: regulation of prostaglandin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] synonym: "regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "regulation of prostaglandin degradation" EXACT [GOC:TermGenie] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905344 ! prostaglandin catabolic process relationship: regulates GO:1905344 ! prostaglandin catabolic process created_by: slaulederkind creation_date: 2017-01-16T21:36:39Z [Term] id: GO:1905829 name: negative regulation of prostaglandin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] synonym: "down regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "downregulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "inhibition of prostaglandin breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of prostaglandin catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of prostaglandin catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of prostaglandin degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of prostaglandin degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:1905828 ! regulation of prostaglandin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905344 ! prostaglandin catabolic process relationship: negatively_regulates GO:1905344 ! prostaglandin catabolic process created_by: slaulederkind creation_date: 2017-01-16T21:36:48Z [Term] id: GO:1905830 name: positive regulation of prostaglandin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] synonym: "activation of prostaglandin breakdown" NARROW [GOC:TermGenie] synonym: "activation of prostaglandin catabolic process" NARROW [GOC:TermGenie] synonym: "activation of prostaglandin catabolism" NARROW [GOC:TermGenie] synonym: "activation of prostaglandin degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "up regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of prostaglandin degradation" EXACT [GOC:TermGenie] synonym: "upregulation of prostaglandin breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of prostaglandin catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of prostaglandin degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:1905828 ! regulation of prostaglandin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905344 ! prostaglandin catabolic process relationship: positively_regulates GO:1905344 ! prostaglandin catabolic process created_by: slaulederkind creation_date: 2017-01-16T21:36:56Z [Term] id: GO:1905831 name: negative regulation of spindle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "downregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of spindle formation" EXACT [GOC:TermGenie] synonym: "inhibition of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "inhibition of spindle assembly" NARROW [GOC:TermGenie] synonym: "inhibition of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of spindle formation" NARROW [GOC:TermGenie] synonym: "negative regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051225 ! spindle assembly relationship: negatively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:37Z [Term] id: GO:1905832 name: positive regulation of spindle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "activation of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of bipolar spindle formation" NARROW [GOC:TermGenie] synonym: "activation of spindle assembly" NARROW [GOC:TermGenie] synonym: "activation of spindle biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of spindle formation" NARROW [GOC:TermGenie] synonym: "positive regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of bipolar spindle formation" EXACT [GOC:TermGenie] synonym: "upregulation of spindle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of spindle biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of spindle formation" EXACT [GOC:TermGenie] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:0090169 ! regulation of spindle assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051225 ! spindle assembly relationship: positively_regulates GO:0051225 ! spindle assembly created_by: hbye creation_date: 2017-01-17T10:26:46Z [Term] id: GO:1905833 name: negative regulation of microtubule nucleation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031115 ! negative regulation of microtubule polymerization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007020 ! microtubule nucleation relationship: negatively_regulates GO:0007020 ! microtubule nucleation created_by: hbye creation_date: 2017-01-17T12:00:56Z [Term] id: GO:1905834 name: response to pyrimidine ribonucleotide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound created_by: slaulederkind creation_date: 2017-01-17T19:23:59Z [Term] id: GO:1905835 name: cellular response to pyrimidine ribonucleotide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905834 ! response to pyrimidine ribonucleotide created_by: slaulederkind creation_date: 2017-01-17T19:24:09Z [Term] id: GO:1905836 name: response to triterpenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994] is_a: GO:0033993 ! response to lipid created_by: slaulederkind creation_date: 2017-01-17T19:37:36Z [Term] id: GO:1905837 name: cellular response to triterpenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994] is_a: GO:0071396 ! cellular response to lipid is_a: GO:1905836 ! response to triterpenoid created_by: slaulederkind creation_date: 2017-01-17T19:37:44Z [Term] id: GO:1905838 name: regulation of telomeric D-loop disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] is_a: GO:1904533 ! regulation of telomeric loop disassembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061820 ! telomeric D-loop disassembly relationship: regulates GO:0061820 ! telomeric D-loop disassembly created_by: NancyCampbell creation_date: 2017-01-18T11:01:38Z [Term] id: GO:1905839 name: negative regulation of telomeric D-loop disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] synonym: "down regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of telomeric D-loop disassembly" NARROW [GOC:TermGenie] is_a: GO:1904534 ! negative regulation of telomeric loop disassembly is_a: GO:1905838 ! regulation of telomeric D-loop disassembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061820 ! telomeric D-loop disassembly relationship: negatively_regulates GO:0061820 ! telomeric D-loop disassembly created_by: NancyCampbell creation_date: 2017-01-18T11:01:47Z [Term] id: GO:1905840 name: positive regulation of telomeric D-loop disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] synonym: "activation of telomeric D-loop disassembly" NARROW [GOC:TermGenie] synonym: "up regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] is_a: GO:1904535 ! positive regulation of telomeric loop disassembly is_a: GO:1905838 ! regulation of telomeric D-loop disassembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061820 ! telomeric D-loop disassembly relationship: positively_regulates GO:0061820 ! telomeric D-loop disassembly created_by: NancyCampbell creation_date: 2017-01-18T11:01:55Z [Term] id: GO:1905841 name: response to oxidopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] is_a: GO:0009636 ! response to toxic substance is_a: GO:0071869 ! response to catecholamine created_by: paolaroncaglia creation_date: 2017-01-19T09:49:03Z [Term] id: GO:1905842 name: cellular response to oxidopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1905841 ! response to oxidopamine created_by: paolaroncaglia creation_date: 2017-01-19T09:49:12Z [Term] id: GO:1905843 name: regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071480 ! cellular response to gamma radiation relationship: regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:39Z [Term] id: GO:1905844 name: negative regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "down regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "down regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "downregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to gamma radiation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "inhibition of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1905843 ! regulation of cellular response to gamma radiation is_a: GO:2001229 ! negative regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071480 ! cellular response to gamma radiation relationship: negatively_regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:48Z [Term] id: GO:1905845 name: positive regulation of cellular response to gamma radiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] synonym: "activation of cellular response to gamma radiation" NARROW [GOC:TermGenie] synonym: "activation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "activation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "up regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] synonym: "upregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1905843 ! regulation of cellular response to gamma radiation is_a: GO:2001230 ! positive regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071480 ! cellular response to gamma radiation relationship: positively_regulates GO:0071480 ! cellular response to gamma radiation created_by: rozaru creation_date: 2017-01-19T10:24:57Z [Term] id: GO:1905846 name: regulation of cellular response to oxidopamine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905842 ! cellular response to oxidopamine relationship: regulates GO:1905842 ! cellular response to oxidopamine created_by: rozaru creation_date: 2017-01-19T10:46:46Z [Term] id: GO:1905847 name: negative regulation of cellular response to oxidopamine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] synonym: "down regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to oxidopamine" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905846 ! regulation of cellular response to oxidopamine intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905842 ! cellular response to oxidopamine relationship: negatively_regulates GO:1905842 ! cellular response to oxidopamine created_by: rozaru creation_date: 2017-01-19T10:46:55Z [Term] id: GO:1905848 name: positive regulation of cellular response to oxidopamine namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] synonym: "activation of cellular response to oxidopamine" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905846 ! regulation of cellular response to oxidopamine intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905842 ! cellular response to oxidopamine relationship: positively_regulates GO:1905842 ! cellular response to oxidopamine created_by: rozaru creation_date: 2017-01-19T10:47:04Z [Term] id: GO:1905849 name: negative regulation of forward locomotion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] synonym: "down regulation of forward locomotion" EXACT [GOC:TermGenie] synonym: "down-regulation of forward locomotion" EXACT [GOC:TermGenie] synonym: "downregulation of forward locomotion" EXACT [GOC:TermGenie] synonym: "inhibition of forward locomotion" NARROW [GOC:TermGenie] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0043059 ! regulation of forward locomotion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043056 ! forward locomotion relationship: negatively_regulates GO:0043056 ! forward locomotion created_by: rozaru creation_date: 2017-01-23T11:03:55Z [Term] id: GO:1905850 name: positive regulation of forward locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] synonym: "activation of forward locomotion" NARROW [GOC:TermGenie] synonym: "up regulation of forward locomotion" EXACT [GOC:TermGenie] synonym: "up-regulation of forward locomotion" EXACT [GOC:TermGenie] synonym: "upregulation of forward locomotion" EXACT [GOC:TermGenie] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0043059 ! regulation of forward locomotion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043056 ! forward locomotion relationship: positively_regulates GO:0043056 ! forward locomotion created_by: rozaru creation_date: 2017-01-23T11:04:05Z [Term] id: GO:1905851 name: negative regulation of backward locomotion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] synonym: "down regulation of backward locomotion" EXACT [GOC:TermGenie] synonym: "down-regulation of backward locomotion" EXACT [GOC:TermGenie] synonym: "downregulation of backward locomotion" EXACT [GOC:TermGenie] synonym: "inhibition of backward locomotion" NARROW [GOC:TermGenie] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0043058 ! regulation of backward locomotion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043057 ! backward locomotion relationship: negatively_regulates GO:0043057 ! backward locomotion created_by: rozaru creation_date: 2017-01-23T11:04:16Z [Term] id: GO:1905852 name: positive regulation of backward locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] synonym: "activation of backward locomotion" NARROW [GOC:TermGenie] synonym: "up regulation of backward locomotion" EXACT [GOC:TermGenie] synonym: "up-regulation of backward locomotion" EXACT [GOC:TermGenie] synonym: "upregulation of backward locomotion" EXACT [GOC:TermGenie] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0043058 ! regulation of backward locomotion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043057 ! backward locomotion relationship: positively_regulates GO:0043057 ! backward locomotion created_by: rozaru creation_date: 2017-01-23T11:04:25Z [Term] id: GO:1905853 name: regulation of heparan sulfate binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] is_a: GO:0051098 ! regulation of binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904399 ! heparan sulfate binding relationship: regulates GO:1904399 ! heparan sulfate binding created_by: BarbaraCzub creation_date: 2017-01-23T13:25:30Z [Term] id: GO:1905854 name: negative regulation of heparan sulfate binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] synonym: "down regulation of heparan sulfate binding" EXACT [GOC:TermGenie] synonym: "down-regulation of heparan sulfate binding" EXACT [GOC:TermGenie] synonym: "downregulation of heparan sulfate binding" EXACT [GOC:TermGenie] synonym: "inhibition of heparan sulfate binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding is_a: GO:1905853 ! regulation of heparan sulfate binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904399 ! heparan sulfate binding relationship: negatively_regulates GO:1904399 ! heparan sulfate binding created_by: BarbaraCzub creation_date: 2017-01-23T13:25:38Z [Term] id: GO:1905855 name: positive regulation of heparan sulfate binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] synonym: "activation of heparan sulfate binding" NARROW [GOC:TermGenie] synonym: "up regulation of heparan sulfate binding" EXACT [GOC:TermGenie] synonym: "up-regulation of heparan sulfate binding" EXACT [GOC:TermGenie] synonym: "upregulation of heparan sulfate binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding is_a: GO:1905853 ! regulation of heparan sulfate binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904399 ! heparan sulfate binding relationship: positively_regulates GO:1904399 ! heparan sulfate binding created_by: BarbaraCzub creation_date: 2017-01-23T13:25:47Z [Term] id: GO:1905856 name: negative regulation of pentose-phosphate shunt namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259] is_a: GO:0043456 ! regulation of pentose-phosphate shunt is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006098 ! pentose-phosphate shunt relationship: negatively_regulates GO:0006098 ! pentose-phosphate shunt created_by: ValWood creation_date: 2017-01-23T14:00:18Z [Term] id: GO:1905857 name: positive regulation of pentose-phosphate shunt namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259] is_a: GO:0043456 ! regulation of pentose-phosphate shunt is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006098 ! pentose-phosphate shunt relationship: positively_regulates GO:0006098 ! pentose-phosphate shunt created_by: ValWood creation_date: 2017-01-23T14:00:26Z [Term] id: GO:1905858 name: regulation of heparan sulfate proteoglycan binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] synonym: "regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043395 ! heparan sulfate proteoglycan binding relationship: regulates GO:0043395 ! heparan sulfate proteoglycan binding created_by: BarbaraCzub creation_date: 2017-01-23T14:25:10Z [Term] id: GO:1905859 name: negative regulation of heparan sulfate proteoglycan binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] synonym: "down regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "down regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "down-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "down-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "downregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "downregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "inhibition of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie] synonym: "inhibition of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "negative regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043395 ! heparan sulfate proteoglycan binding relationship: negatively_regulates GO:0043395 ! heparan sulfate proteoglycan binding created_by: BarbaraCzub creation_date: 2017-01-23T14:25:19Z [Term] id: GO:1905860 name: positive regulation of heparan sulfate proteoglycan binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] synonym: "activation of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie] synonym: "activation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "positive regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "up regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "up regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "up-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "up-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] synonym: "upregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] synonym: "upregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043395 ! heparan sulfate proteoglycan binding relationship: positively_regulates GO:0043395 ! heparan sulfate proteoglycan binding created_by: BarbaraCzub creation_date: 2017-01-23T14:25:27Z [Term] id: GO:1905861 name: intranuclear rod assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an intranuclear rod." [GO_REF:0000079, GOC:TermGenie, PMID:28074884] synonym: "intranuclear actin rod assembly" EXACT [GOC:TermGenie] synonym: "intranuclear actin rod formation" EXACT [GOC:TermGenie] synonym: "intranuclear rod formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:0097435 ! supramolecular fiber organization created_by: ukemi creation_date: 2017-01-23T17:59:27Z [Term] id: GO:1905862 name: ferroxidase complex namespace: cellular_component def: "A protein complex which is capable of ferroxidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16522632] comment: An example of this is FET3 in Saccharomyces cerevisiae (P38993) in PMID:16522632 (inferred from direct assay). is_a: GO:1990204 ! oxidoreductase complex created_by: bmeldal creation_date: 2017-01-25T10:01:39Z [Term] id: GO:1905863 name: invadopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an invadopodium." [GO_REF:000103, GOC:TermGenie, PMID:15684033] is_a: GO:0120036 ! plasma membrane bounded cell projection organization created_by: slaulederkind creation_date: 2017-01-25T22:54:14Z [Term] id: GO:1905864 name: regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:26Z [Term] id: GO:1905865 name: negative regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "down regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "down regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "inhibition of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of Atg1p signalling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] synonym: "inhibition of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] synonym: "negative regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:35Z [Term] id: GO:1905866 name: positive regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "activation of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "activation of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of Atg1p signalling complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1 signaling complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] synonym: "activation of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] synonym: "positive regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly relationship: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly created_by: paolaroncaglia creation_date: 2017-01-26T13:23:44Z [Term] id: GO:1905867 name: epididymis development namespace: biological_process def: "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12388089] synonym: "epididymus development" EXACT [GOC:TermGenie] is_a: GO:0035295 ! tube development is_a: GO:0048608 ! reproductive structure development created_by: slaulederkind creation_date: 2017-01-27T00:00:33Z [Term] id: GO:1905868 name: regulation of 3'-UTR-mediated mRNA stabilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] synonym: "regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] is_a: GO:0043488 ! regulation of mRNA stability intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization relationship: regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization created_by: rozaru creation_date: 2017-01-27T11:51:37Z [Term] id: GO:1905869 name: negative regulation of 3'-UTR-mediated mRNA stabilization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] synonym: "down regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "down regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "down-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "down-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "downregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "downregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "inhibition of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie] synonym: "inhibition of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie] synonym: "negative regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization relationship: negatively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization created_by: rozaru creation_date: 2017-01-27T11:51:46Z [Term] id: GO:1905870 name: positive regulation of 3'-UTR-mediated mRNA stabilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] synonym: "activation of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie] synonym: "activation of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie] synonym: "positive regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "up regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "up regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "up-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "up-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "upregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] synonym: "upregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization relationship: positively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization created_by: rozaru creation_date: 2017-01-27T11:51:55Z [Term] id: GO:1905871 name: regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902463 ! protein localization to cell leading edge relationship: regulates GO:1902463 ! protein localization to cell leading edge created_by: slaulederkind creation_date: 2017-01-27T19:34:55Z [Term] id: GO:1905872 name: negative regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902463 ! protein localization to cell leading edge relationship: negatively_regulates GO:1902463 ! protein localization to cell leading edge created_by: slaulederkind creation_date: 2017-01-27T19:35:04Z [Term] id: GO:1905873 name: positive regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902463 ! protein localization to cell leading edge relationship: positively_regulates GO:1902463 ! protein localization to cell leading edge created_by: slaulederkind creation_date: 2017-01-27T19:35:13Z [Term] id: GO:1905874 name: regulation of postsynaptic density organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] synonym: "regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "regulation of PSD organization" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097106 ! postsynaptic density organization relationship: regulates GO:0097106 ! postsynaptic density organization created_by: slaulederkind creation_date: 2017-01-27T19:53:32Z [Term] id: GO:1905875 name: negative regulation of postsynaptic density organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] synonym: "down regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "down regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "down regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "down regulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "down regulation of PSD organization" EXACT [GOC:TermGenie] synonym: "down-regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "down-regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "down-regulation of PSD organization" EXACT [GOC:TermGenie] synonym: "downregulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "downregulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "downregulation of PSD organization" EXACT [GOC:TermGenie] synonym: "inhibition of post synaptic density organization" NARROW [GOC:TermGenie] synonym: "inhibition of post-synaptic density organization" NARROW [GOC:TermGenie] synonym: "inhibition of postsynaptic density organisation" NARROW [GOC:TermGenie] synonym: "inhibition of postsynaptic density organization" NARROW [GOC:TermGenie] synonym: "inhibition of PSD organization" NARROW [GOC:TermGenie] synonym: "negative regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "negative regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "negative regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of PSD organization" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905809 ! negative regulation of synapse organization is_a: GO:1905874 ! regulation of postsynaptic density organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097106 ! postsynaptic density organization relationship: negatively_regulates GO:0097106 ! postsynaptic density organization created_by: slaulederkind creation_date: 2017-01-27T19:53:41Z [Term] id: GO:1905876 name: positive regulation of postsynaptic density organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] synonym: "activation of post synaptic density organization" NARROW [GOC:TermGenie] synonym: "activation of post-synaptic density organization" NARROW [GOC:TermGenie] synonym: "activation of postsynaptic density organisation" NARROW [GOC:TermGenie] synonym: "activation of postsynaptic density organization" NARROW [GOC:TermGenie] synonym: "activation of PSD organization" NARROW [GOC:TermGenie] synonym: "positive regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "positive regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "positive regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of PSD organization" EXACT [GOC:TermGenie] synonym: "up regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "up regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "up regulation of PSD organization" EXACT [GOC:TermGenie] synonym: "up-regulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "up-regulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "up-regulation of PSD organization" EXACT [GOC:TermGenie] synonym: "upregulation of post synaptic density organization" EXACT [GOC:TermGenie] synonym: "upregulation of post-synaptic density organization" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic density organisation" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic density organization" EXACT [GOC:TermGenie] synonym: "upregulation of PSD organization" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1905874 ! regulation of postsynaptic density organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097106 ! postsynaptic density organization relationship: positively_regulates GO:0097106 ! postsynaptic density organization created_by: slaulederkind creation_date: 2017-01-27T19:53:50Z [Term] id: GO:1905877 name: invadopodium assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an invadopodium." [GO_REF:0000079, GOC:TermGenie, PMID:15684033] synonym: "invadopodium formation" EXACT [GOC:TermGenie] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly is_a: GO:1905863 ! invadopodium organization created_by: slaulederkind creation_date: 2017-01-27T20:44:07Z [Term] id: GO:1905878 name: invadopodium disassembly namespace: biological_process def: "The disaggregation of an invadopodium into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:15684033] is_a: GO:0022411 ! cellular component disassembly is_a: GO:1905863 ! invadopodium organization created_by: slaulederkind creation_date: 2017-01-27T20:44:16Z [Term] id: GO:1905879 name: regulation of oogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048477 ! oogenesis relationship: regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:05Z [Term] id: GO:1905880 name: negative regulation of oogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048477 ! oogenesis relationship: negatively_regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:15Z [Term] id: GO:1905881 name: positive regulation of oogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of oogenesis" NARROW [GOC:TermGenie] synonym: "activation of ovum development" NARROW [GOC:TermGenie] synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048477 ! oogenesis relationship: positively_regulates GO:0048477 ! oogenesis created_by: hbye creation_date: 2017-01-31T09:31:23Z [Term] id: GO:1905882 name: obsolete other organism cell wall namespace: cellular_component def: "OBSOLETE. Any cell wall that is part of a other organism." [GO_REF:0000064, GOC:TermGenie, PMID:12438152] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: pgarmiri creation_date: 2017-01-31T10:57:28Z [Term] id: GO:1905883 name: regulation of triglyceride transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] synonym: "regulation of triacylglycerol transport" EXACT [GOC:TermGenie] is_a: GO:1901506 ! regulation of acylglycerol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034197 ! triglyceride transport relationship: regulates GO:0034197 ! triglyceride transport created_by: rozaru creation_date: 2017-01-31T11:32:29Z [Term] id: GO:1905884 name: negative regulation of triglyceride transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] synonym: "down regulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "down regulation of triglyceride transport" EXACT [GOC:TermGenie] synonym: "down-regulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "down-regulation of triglyceride transport" EXACT [GOC:TermGenie] synonym: "downregulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "downregulation of triglyceride transport" EXACT [GOC:TermGenie] synonym: "inhibition of triacylglycerol transport" NARROW [GOC:TermGenie] synonym: "inhibition of triglyceride transport" NARROW [GOC:TermGenie] synonym: "negative regulation of triacylglycerol transport" EXACT [GOC:TermGenie] is_a: GO:1901507 ! negative regulation of acylglycerol transport is_a: GO:1905883 ! regulation of triglyceride transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034197 ! triglyceride transport relationship: negatively_regulates GO:0034197 ! triglyceride transport created_by: rozaru creation_date: 2017-01-31T11:32:39Z [Term] id: GO:1905885 name: positive regulation of triglyceride transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] synonym: "activation of triacylglycerol transport" NARROW [GOC:TermGenie] synonym: "activation of triglyceride transport" NARROW [GOC:TermGenie] synonym: "positive regulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "up regulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "up regulation of triglyceride transport" EXACT [GOC:TermGenie] synonym: "up-regulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "up-regulation of triglyceride transport" EXACT [GOC:TermGenie] synonym: "upregulation of triacylglycerol transport" EXACT [GOC:TermGenie] synonym: "upregulation of triglyceride transport" EXACT [GOC:TermGenie] is_a: GO:1901508 ! positive regulation of acylglycerol transport is_a: GO:1905883 ! regulation of triglyceride transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034197 ! triglyceride transport relationship: positively_regulates GO:0034197 ! triglyceride transport created_by: rozaru creation_date: 2017-01-31T11:32:47Z [Term] id: GO:1905886 name: chromatin remodeling involved in meiosis I namespace: biological_process def: "Any chromatin remodeling that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:19139281, PMID:25934010, PMID:9106659] synonym: "chromatin modeling involved in meiosis I" EXACT [GOC:TermGenie] synonym: "chromatin modelling involved in meiosis I" EXACT [GOC:TermGenie] synonym: "chromatin remodelling involved in meiosis I" EXACT [GOC:TermGenie] synonym: "meiosis-specific chromatin remodeling" EXACT [PMID:19139281] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0061982 ! meiosis I cell cycle process created_by: mah11 creation_date: 2017-01-31T14:29:00Z [Term] id: GO:1905887 name: autoinducer AI-2 transmembrane transport namespace: biological_process def: "The process in which (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol (autoinducer AI-2) is transported across a membrane. AI-2 is produced by prokaryotes and is believed to play a role in quorum sensing." [GO_REF:0000069, GOC:TermGenie, PMID:15601708] synonym: "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport" EXACT [PMID:15601708] synonym: "AI-2 transmembrane transport" EXACT [PMID:15601708] synonym: "autoinducer 2 transmembrane transport" EXACT [PMID:15601708] is_a: GO:0015791 ! polyol transport is_a: GO:0055085 ! transmembrane transport created_by: dosumis creation_date: 2017-01-31T14:34:50Z [Term] id: GO:1905888 name: negative regulation of cellular response to very-low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] synonym: "down regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "down regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus relationship: negatively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus created_by: BarbaraCzub creation_date: 2017-02-01T10:09:25Z [Term] id: GO:1905889 name: positive regulation of cellular response to very-low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] synonym: "activation of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie] synonym: "activation of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus relationship: positively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus created_by: BarbaraCzub creation_date: 2017-02-01T10:09:34Z [Term] id: GO:1905890 name: regulation of cellular response to very-low-density lipoprotein particle stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] synonym: "regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus relationship: regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus created_by: BarbaraCzub creation_date: 2017-02-01T10:09:16Z [Term] id: GO:1905891 name: regulation of cellular response to thapsigargin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904579 ! cellular response to thapsigargin relationship: regulates GO:1904579 ! cellular response to thapsigargin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:07Z [Term] id: GO:1905892 name: negative regulation of cellular response to thapsigargin namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "down regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to thapsigargin" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905891 ! regulation of cellular response to thapsigargin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904579 ! cellular response to thapsigargin relationship: negatively_regulates GO:1904579 ! cellular response to thapsigargin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:15Z [Term] id: GO:1905893 name: positive regulation of cellular response to thapsigargin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "activation of cellular response to thapsigargin" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905891 ! regulation of cellular response to thapsigargin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904579 ! cellular response to thapsigargin relationship: positively_regulates GO:1904579 ! cellular response to thapsigargin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:24Z [Term] id: GO:1905894 name: regulation of cellular response to tunicamycin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904577 ! cellular response to tunicamycin relationship: regulates GO:1904577 ! cellular response to tunicamycin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:34Z [Term] id: GO:1905895 name: negative regulation of cellular response to tunicamycin namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "down regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to tunicamycin" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905894 ! regulation of cellular response to tunicamycin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904577 ! cellular response to tunicamycin relationship: negatively_regulates GO:1904577 ! cellular response to tunicamycin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:42Z [Term] id: GO:1905896 name: positive regulation of cellular response to tunicamycin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "activation of cellular response to tunicamycin" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905894 ! regulation of cellular response to tunicamycin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904577 ! cellular response to tunicamycin relationship: positively_regulates GO:1904577 ! cellular response to tunicamycin created_by: BarbaraCzub creation_date: 2017-02-01T11:36:51Z [Term] id: GO:1905897 name: regulation of response to endoplasmic reticulum stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "regulation of response to ER stress" EXACT [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034976 ! response to endoplasmic reticulum stress relationship: regulates GO:0034976 ! response to endoplasmic reticulum stress created_by: BarbaraCzub creation_date: 2017-02-01T11:42:55Z [Term] id: GO:1905898 name: positive regulation of response to endoplasmic reticulum stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] synonym: "activation of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "activation of ER stress response" NARROW [GOC:TermGenie] synonym: "activation of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] synonym: "activation of response to ER stress" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "positive regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "up regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "up regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up regulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of ER stress response" EXACT [GOC:TermGenie] synonym: "up-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ER stress" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of ER stress response" EXACT [GOC:TermGenie] synonym: "upregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to ER stress" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034976 ! response to endoplasmic reticulum stress relationship: positively_regulates GO:0034976 ! response to endoplasmic reticulum stress created_by: BarbaraCzub creation_date: 2017-02-01T11:43:03Z [Term] id: GO:1905899 name: regulation of smooth muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048745 ! smooth muscle tissue development relationship: regulates GO:0048745 ! smooth muscle tissue development created_by: bmeldal creation_date: 2017-02-01T14:31:16Z [Term] id: GO:1905900 name: negative regulation of smooth muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:1901862 ! negative regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048745 ! smooth muscle tissue development relationship: negatively_regulates GO:0048745 ! smooth muscle tissue development created_by: bmeldal creation_date: 2017-02-01T14:31:24Z [Term] id: GO:1905901 name: positive regulation of smooth muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:1901863 ! positive regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048745 ! smooth muscle tissue development relationship: positively_regulates GO:0048745 ! smooth muscle tissue development created_by: bmeldal creation_date: 2017-02-01T14:31:33Z [Term] id: GO:1905902 name: regulation of mesoderm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001707 ! mesoderm formation relationship: regulates GO:0001707 ! mesoderm formation created_by: rachhuntley creation_date: 2017-02-03T12:28:20Z [Term] id: GO:1905903 name: negative regulation of mesoderm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000381 ! negative regulation of mesoderm development is_a: GO:2000542 ! negative regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001707 ! mesoderm formation relationship: negatively_regulates GO:0001707 ! mesoderm formation created_by: rachhuntley creation_date: 2017-02-03T12:28:29Z [Term] id: GO:1905904 name: positive regulation of mesoderm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000382 ! positive regulation of mesoderm development is_a: GO:2000543 ! positive regulation of gastrulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001707 ! mesoderm formation relationship: positively_regulates GO:0001707 ! mesoderm formation created_by: rachhuntley creation_date: 2017-02-03T12:28:38Z [Term] id: GO:1905905 name: pharyngeal gland morphogenesis namespace: biological_process def: "The developmental process by which a pharyngeal gland is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:21868609] synonym: "glandulae pharyngeae morphogenesis" RELATED [GOC:TermGenie] synonym: "pharynx gland morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022612 ! gland morphogenesis created_by: rozaru creation_date: 2017-02-03T14:39:10Z [Term] id: GO:1905906 name: regulation of amyloid fibril formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). synonym: "regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "regulation of amyloid structure formation" RELATED [GOC:TermGenie] is_a: GO:0051246 ! regulation of protein metabolic process is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990000 ! amyloid fibril formation relationship: regulates GO:1990000 ! amyloid fibril formation created_by: BarbaraCzub creation_date: 2017-02-03T15:43:48Z [Term] id: GO:1905907 name: negative regulation of amyloid fibril formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). synonym: "down regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "down regulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "down regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "down regulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "down-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "down-regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "downregulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "downregulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "downregulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "downregulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "inhibition of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "inhibition of amyloid fibril formation" NARROW [GOC:TermGenie] synonym: "inhibition of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "inhibition of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "negative regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of amyloid structure formation" RELATED [GOC:TermGenie] is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1905906 ! regulation of amyloid fibril formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990000 ! amyloid fibril formation relationship: negatively_regulates GO:1990000 ! amyloid fibril formation created_by: BarbaraCzub creation_date: 2017-02-03T15:43:56Z [Term] id: GO:1905908 name: positive regulation of amyloid fibril formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). synonym: "activation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "activation of amyloid fibril formation" NARROW [GOC:TermGenie] synonym: "activation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "activation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "positive regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "up regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "up regulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "up regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "up regulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "up-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "up-regulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of amyloid structure formation" RELATED [GOC:TermGenie] synonym: "upregulation of amyloid fibril assembly" RELATED [GOC:TermGenie] synonym: "upregulation of amyloid fibril formation" EXACT [GOC:TermGenie] synonym: "upregulation of amyloid structure assembly" RELATED [GOC:TermGenie] synonym: "upregulation of amyloid structure formation" RELATED [GOC:TermGenie] is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1905906 ! regulation of amyloid fibril formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990000 ! amyloid fibril formation relationship: positively_regulates GO:1990000 ! amyloid fibril formation created_by: BarbaraCzub creation_date: 2017-02-03T15:44:05Z [Term] id: GO:1905909 name: regulation of dauer entry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] synonym: "regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] is_a: GO:0061065 ! regulation of dauer larval development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043053 ! dauer entry relationship: regulates GO:0043053 ! dauer entry created_by: hbye creation_date: 2017-02-06T15:34:01Z [Term] id: GO:1905910 name: negative regulation of dauer entry namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] synonym: "down regulation of dauer entry" EXACT [GOC:TermGenie] synonym: "down regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "down-regulation of dauer entry" EXACT [GOC:TermGenie] synonym: "down-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "downregulation of dauer entry" EXACT [GOC:TermGenie] synonym: "downregulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "inhibition of dauer entry" NARROW [GOC:TermGenie] synonym: "inhibition of nematode entry into dormancy" NARROW [GOC:TermGenie] synonym: "negative regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] is_a: GO:0061067 ! negative regulation of dauer larval development is_a: GO:1905909 ! regulation of dauer entry intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043053 ! dauer entry relationship: negatively_regulates GO:0043053 ! dauer entry created_by: hbye creation_date: 2017-02-06T15:34:11Z [Term] id: GO:1905911 name: positive regulation of dauer entry namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] synonym: "activation of dauer entry" NARROW [GOC:TermGenie] synonym: "activation of nematode entry into dormancy" NARROW [GOC:TermGenie] synonym: "positive regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "up regulation of dauer entry" EXACT [GOC:TermGenie] synonym: "up regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "up-regulation of dauer entry" EXACT [GOC:TermGenie] synonym: "up-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] synonym: "upregulation of dauer entry" EXACT [GOC:TermGenie] synonym: "upregulation of nematode entry into dormancy" EXACT [GOC:TermGenie] is_a: GO:0061066 ! positive regulation of dauer larval development is_a: GO:1905909 ! regulation of dauer entry intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043053 ! dauer entry relationship: positively_regulates GO:0043053 ! dauer entry created_by: hbye creation_date: 2017-02-06T15:34:20Z [Term] id: GO:1905912 name: regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "regulation of calcium ion export from cell" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1903169 ! regulation of calcium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990034 ! calcium ion export across plasma membrane relationship: regulates GO:1990034 ! calcium ion export across plasma membrane created_by: rachhuntley creation_date: 2017-02-07T13:20:39Z [Term] id: GO:1905913 name: negative regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "down regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "down regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion efflux from cell" NARROW [GOC:TermGenie] synonym: "inhibition of calcium ion export from cell" NARROW [GOC:TermGenie] synonym: "negative regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "negative regulation of calcium ion export from cell" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane relationship: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane created_by: rachhuntley creation_date: 2017-02-07T13:20:48Z [Term] id: GO:1905914 name: positive regulation of calcium ion export across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] synonym: "activation of calcium ion efflux from cell" NARROW [GOC:TermGenie] synonym: "activation of calcium ion export from cell" NARROW [GOC:TermGenie] synonym: "positive regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "positive regulation of calcium ion export from cell" EXACT [] synonym: "up regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "up regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "up-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] synonym: "upregulation of calcium ion export from cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1990034 ! calcium ion export across plasma membrane relationship: positively_regulates GO:1990034 ! calcium ion export across plasma membrane created_by: rachhuntley creation_date: 2017-02-07T13:20:56Z [Term] id: GO:1905915 name: regulation of cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0090679 ! cell differentiation involved in phenotypic switching relationship: regulates GO:0090679 ! cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-08T12:23:14Z [Term] id: GO:1905916 name: negative regulation of cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "down regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "downregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "inhibition of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1900240 ! negative regulation of phenotypic switching is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching relationship: negatively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-08T12:23:23Z [Term] id: GO:1905917 name: positive regulation of cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "activation of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "up regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1900241 ! positive regulation of phenotypic switching is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching relationship: positively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-08T12:23:31Z [Term] id: GO:1905918 name: regulation of CoA-transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008410 ! CoA-transferase activity relationship: regulates GO:0008410 ! CoA-transferase activity created_by: BarbaraCzub creation_date: 2017-02-08T13:00:48Z [Term] id: GO:1905919 name: negative regulation of CoA-transferase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "down regulation of CoA-transferase activity" EXACT [GOC:TermGenie] synonym: "down-regulation of CoA-transferase activity" EXACT [GOC:TermGenie] synonym: "downregulation of CoA-transferase activity" EXACT [GOC:TermGenie] synonym: "inhibition of CoA-transferase activity" NARROW [GOC:TermGenie] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:1905918 ! regulation of CoA-transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008410 ! CoA-transferase activity relationship: negatively_regulates GO:0008410 ! CoA-transferase activity created_by: BarbaraCzub creation_date: 2017-02-08T13:00:56Z [Term] id: GO:1905920 name: positive regulation of CoA-transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "activation of CoA-transferase activity" NARROW [GOC:TermGenie] synonym: "up regulation of CoA-transferase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of CoA-transferase activity" EXACT [GOC:TermGenie] synonym: "upregulation of CoA-transferase activity" EXACT [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1905918 ! regulation of CoA-transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008410 ! CoA-transferase activity relationship: positively_regulates GO:0008410 ! CoA-transferase activity created_by: BarbaraCzub creation_date: 2017-02-08T13:01:04Z [Term] id: GO:1905921 name: regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008292 ! acetylcholine biosynthetic process relationship: regulates GO:0008292 ! acetylcholine biosynthetic process created_by: BarbaraCzub creation_date: 2017-02-08T13:08:30Z [Term] id: GO:1905922 name: negative regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process relationship: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process created_by: BarbaraCzub creation_date: 2017-02-08T13:08:39Z [Term] id: GO:1905923 name: positive regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008292 ! acetylcholine biosynthetic process relationship: positively_regulates GO:0008292 ! acetylcholine biosynthetic process created_by: BarbaraCzub creation_date: 2017-02-08T13:08:48Z [Term] id: GO:1905924 name: regulation of invadopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] synonym: "regulation of invadopodium formation" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1905877 ! invadopodium assembly relationship: regulates GO:1905877 ! invadopodium assembly created_by: slaulederkind creation_date: 2017-02-08T21:38:30Z [Term] id: GO:1905925 name: negative regulation of invadopodium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] synonym: "down regulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "down-regulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "downregulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "inhibition of invadopodium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of invadopodium formation" NARROW [GOC:TermGenie] synonym: "negative regulation of invadopodium formation" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1905924 ! regulation of invadopodium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1905877 ! invadopodium assembly relationship: negatively_regulates GO:1905877 ! invadopodium assembly created_by: slaulederkind creation_date: 2017-02-08T21:38:39Z [Term] id: GO:1905926 name: positive regulation of invadopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] synonym: "activation of invadopodium assembly" NARROW [GOC:TermGenie] synonym: "activation of invadopodium formation" NARROW [GOC:TermGenie] synonym: "positive regulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "up regulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "up regulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "up-regulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of invadopodium formation" EXACT [GOC:TermGenie] synonym: "upregulation of invadopodium assembly" EXACT [GOC:TermGenie] synonym: "upregulation of invadopodium formation" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1905924 ! regulation of invadopodium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1905877 ! invadopodium assembly relationship: positively_regulates GO:1905877 ! invadopodium assembly created_by: slaulederkind creation_date: 2017-02-08T21:38:48Z [Term] id: GO:1905927 name: regulation of invadopodium disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1905878 ! invadopodium disassembly relationship: regulates GO:1905878 ! invadopodium disassembly created_by: slaulederkind creation_date: 2017-02-08T21:38:57Z [Term] id: GO:1905928 name: negative regulation of invadopodium disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] synonym: "down regulation of invadopodium disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of invadopodium disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of invadopodium disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of invadopodium disassembly" NARROW [GOC:TermGenie] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:1905927 ! regulation of invadopodium disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1905878 ! invadopodium disassembly relationship: negatively_regulates GO:1905878 ! invadopodium disassembly created_by: slaulederkind creation_date: 2017-02-08T21:39:05Z [Term] id: GO:1905929 name: positive regulation of invadopodium disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] synonym: "activation of invadopodium disassembly" NARROW [GOC:TermGenie] synonym: "up regulation of invadopodium disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of invadopodium disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of invadopodium disassembly" EXACT [GOC:TermGenie] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:1905927 ! regulation of invadopodium disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1905878 ! invadopodium disassembly relationship: positively_regulates GO:1905878 ! invadopodium disassembly created_by: slaulederkind creation_date: 2017-02-08T21:39:14Z [Term] id: GO:1905930 name: regulation of vascular smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching relationship: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-09T09:20:59Z [Term] id: GO:1905931 name: negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "downregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "inhibition of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation is_a: GO:1905916 ! negative regulation of cell differentiation involved in phenotypic switching is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching relationship: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-09T09:21:08Z [Term] id: GO:1905932 name: positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "activation of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "upregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation is_a: GO:1905917 ! positive regulation of cell differentiation involved in phenotypic switching is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching relationship: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching created_by: rachhuntley creation_date: 2017-02-09T09:21:17Z [Term] id: GO:1905933 name: regulation of cell fate determination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] is_a: GO:0010453 ! regulation of cell fate commitment intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001709 ! cell fate determination relationship: regulates GO:0001709 ! cell fate determination created_by: bmeldal creation_date: 2017-02-09T11:25:21Z [Term] id: GO:1905934 name: negative regulation of cell fate determination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] synonym: "down regulation of cell fate determination" EXACT [GOC:TermGenie] synonym: "down-regulation of cell fate determination" EXACT [GOC:TermGenie] synonym: "downregulation of cell fate determination" EXACT [GOC:TermGenie] synonym: "inhibition of cell fate determination" NARROW [GOC:TermGenie] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:1905933 ! regulation of cell fate determination intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001709 ! cell fate determination relationship: negatively_regulates GO:0001709 ! cell fate determination created_by: bmeldal creation_date: 2017-02-09T11:25:30Z [Term] id: GO:1905935 name: positive regulation of cell fate determination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] synonym: "activation of cell fate determination" NARROW [GOC:TermGenie] synonym: "up regulation of cell fate determination" EXACT [GOC:TermGenie] synonym: "up-regulation of cell fate determination" EXACT [GOC:TermGenie] synonym: "upregulation of cell fate determination" EXACT [GOC:TermGenie] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:1905933 ! regulation of cell fate determination intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001709 ! cell fate determination relationship: positively_regulates GO:0001709 ! cell fate determination created_by: bmeldal creation_date: 2017-02-09T11:25:38Z [Term] id: GO:1905936 name: regulation of germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0036093 ! germ cell proliferation relationship: regulates GO:0036093 ! germ cell proliferation created_by: hbye creation_date: 2017-02-09T14:51:31Z [Term] id: GO:1905937 name: negative regulation of germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0036093 ! germ cell proliferation relationship: negatively_regulates GO:0036093 ! germ cell proliferation created_by: hbye creation_date: 2017-02-09T14:51:41Z [Term] id: GO:1905938 name: positive regulation of germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0036093 ! germ cell proliferation relationship: positively_regulates GO:0036093 ! germ cell proliferation created_by: hbye creation_date: 2017-02-09T14:51:51Z [Term] id: GO:1905939 name: regulation of gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008406 ! gonad development relationship: regulates GO:0008406 ! gonad development created_by: hbye creation_date: 2017-02-09T17:01:50Z [Term] id: GO:1905940 name: negative regulation of gonad development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of gonad development" EXACT [GOC:TermGenie] synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of gonad development" NARROW [GOC:TermGenie] synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008406 ! gonad development relationship: negatively_regulates GO:0008406 ! gonad development created_by: hbye creation_date: 2017-02-09T17:01:59Z [Term] id: GO:1905941 name: positive regulation of gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of gonad development" NARROW [GOC:TermGenie] synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of gonad development" EXACT [GOC:TermGenie] synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008406 ! gonad development relationship: positively_regulates GO:0008406 ! gonad development created_by: hbye creation_date: 2017-02-09T17:02:08Z [Term] id: GO:1905942 name: regulation of formation of growth cone in injured axon namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] is_a: GO:0048686 ! regulation of sprouting of injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048689 ! formation of growth cone in injured axon relationship: regulates GO:0048689 ! formation of growth cone in injured axon created_by: rozaru creation_date: 2017-02-13T09:09:05Z [Term] id: GO:1905943 name: negative regulation of formation of growth cone in injured axon namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] synonym: "down regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] synonym: "downregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] synonym: "inhibition of formation of growth cone in injured axon" NARROW [GOC:TermGenie] is_a: GO:0048688 ! negative regulation of sprouting of injured axon is_a: GO:1905942 ! regulation of formation of growth cone in injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048689 ! formation of growth cone in injured axon relationship: negatively_regulates GO:0048689 ! formation of growth cone in injured axon created_by: rozaru creation_date: 2017-02-13T09:09:13Z [Term] id: GO:1905944 name: positive regulation of formation of growth cone in injured axon namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] synonym: "activation of formation of growth cone in injured axon" NARROW [GOC:TermGenie] synonym: "up regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] synonym: "upregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] is_a: GO:0048687 ! positive regulation of sprouting of injured axon is_a: GO:1905942 ! regulation of formation of growth cone in injured axon intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048689 ! formation of growth cone in injured axon relationship: positively_regulates GO:0048689 ! formation of growth cone in injured axon created_by: rozaru creation_date: 2017-02-13T09:09:21Z [Term] id: GO:1905945 name: regulation of response to calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051592 ! response to calcium ion relationship: regulates GO:0051592 ! response to calcium ion created_by: BarbaraCzub creation_date: 2017-02-13T10:56:34Z [Term] id: GO:1905946 name: negative regulation of response to calcium ion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "down regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "down regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "down-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "down-regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "downregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "downregulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "inhibition of response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "inhibition of response to calcium ion" NARROW [GOC:TermGenie] synonym: "negative regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1905945 ! regulation of response to calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051592 ! response to calcium ion relationship: negatively_regulates GO:0051592 ! response to calcium ion created_by: BarbaraCzub creation_date: 2017-02-13T10:56:41Z [Term] id: GO:1905947 name: positive regulation of response to calcium ion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] synonym: "activation of response to Ca2+ ion" NARROW [GOC:TermGenie] synonym: "activation of response to calcium ion" NARROW [GOC:TermGenie] synonym: "positive regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "up-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "up-regulation of response to calcium ion" EXACT [GOC:TermGenie] synonym: "upregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] synonym: "upregulation of response to calcium ion" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1905945 ! regulation of response to calcium ion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051592 ! response to calcium ion relationship: positively_regulates GO:0051592 ! response to calcium ion created_by: BarbaraCzub creation_date: 2017-02-13T10:56:49Z [Term] id: GO:1905948 name: ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)." [GO_REF:0000070, GOC:TermGenie, PMID:18310115] synonym: "3',5'-cyclic GMP transmembrane-transporting ATPase activity" EXACT [] synonym: "ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity" EXACT [] synonym: "ATPase-coupled cGMP transmembrane transporter activity" EXACT [] is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity created_by: hattrill creation_date: 2017-02-16T15:54:51Z [Term] id: GO:1905949 name: negative regulation of calcium ion import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] comment: An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay). synonym: "down regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] synonym: "inhibition of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol is_a: GO:0090281 ! negative regulation of calcium ion import is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane relationship: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane created_by: bmeldal creation_date: 2017-02-17T09:42:30Z [Term] id: GO:1905951 name: mitochondrion DNA recombination namespace: biological_process def: "Any DNA recombination that takes place in mitochondrion." [GO_REF:0000062, GOC:TermGenie, PMID:8087883] synonym: "DNA recombination in mitochondria" EXACT [GOC:TermGenie] is_a: GO:0006310 ! DNA recombination is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006310 ! DNA recombination intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: ValWood creation_date: 2017-02-19T10:48:17Z [Term] id: GO:1905952 name: regulation of lipid localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010876 ! lipid localization relationship: regulates GO:0010876 ! lipid localization created_by: rozaru creation_date: 2017-02-21T12:12:22Z [Term] id: GO:1905953 name: negative regulation of lipid localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010876 ! lipid localization relationship: negatively_regulates GO:0010876 ! lipid localization created_by: rozaru creation_date: 2017-02-21T12:12:41Z [Term] id: GO:1905954 name: positive regulation of lipid localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] synonym: "activation of lipid localization" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010876 ! lipid localization relationship: positively_regulates GO:0010876 ! lipid localization created_by: rozaru creation_date: 2017-02-21T12:12:49Z [Term] id: GO:1905955 name: negative regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061154 ! endothelial tube morphogenesis relationship: negatively_regulates GO:0061154 ! endothelial tube morphogenesis created_by: rachhuntley creation_date: 2017-02-21T15:17:31Z [Term] id: GO:1905956 name: positive regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061154 ! endothelial tube morphogenesis relationship: positively_regulates GO:0061154 ! endothelial tube morphogenesis created_by: rachhuntley creation_date: 2017-02-21T15:17:39Z [Term] id: GO:1905957 name: regulation of cellular response to alcohol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1901419 ! regulation of response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0097306 ! cellular response to alcohol relationship: regulates GO:0097306 ! cellular response to alcohol created_by: hbye creation_date: 2017-02-22T12:03:00Z [Term] id: GO:1905958 name: negative regulation of cellular response to alcohol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to alcohol" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1901420 ! negative regulation of response to alcohol is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097306 ! cellular response to alcohol relationship: negatively_regulates GO:0097306 ! cellular response to alcohol created_by: hbye creation_date: 2017-02-22T12:03:08Z [Term] id: GO:1905959 name: positive regulation of cellular response to alcohol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of cellular response to alcohol" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] synonym: "upregulation of cellular response to alcohol" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1901421 ! positive regulation of response to alcohol is_a: GO:1905957 ! regulation of cellular response to alcohol intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097306 ! cellular response to alcohol relationship: positively_regulates GO:0097306 ! cellular response to alcohol created_by: hbye creation_date: 2017-02-22T12:03:16Z [Term] id: GO:1905960 name: response to differentiation-inducing factor 2 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:19684855, PMID:3355503] synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT [] synonym: "response to DIF-2" RELATED [] synonym: "response to DIF2" RELATED [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:1901654 ! response to ketone created_by: tberardini creation_date: 2017-02-22T18:45:40Z [Term] id: GO:1905961 name: protein-cysteine S-palmitoyltransferase complex namespace: cellular_component def: "A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20851885] comment: An example of this is ERF2 in Saccharomyces cerevisiae (Q06551) in PMID:20851885 (inferred from direct assay) synonym: "Palmitoyltransferase ERF2-SHR5 complex" NARROW [] synonym: "Palmitoyltransferase ERF2/SHR5 complex" NARROW [] is_a: GO:0002178 ! palmitoyltransferase complex created_by: bmeldal creation_date: 2017-02-23T13:33:15Z [Term] id: GO:1905962 name: glutamatergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726] is_a: GO:0030182 ! neuron differentiation created_by: slaulederkind creation_date: 2017-02-23T17:40:43Z [Term] id: GO:1990000 name: amyloid fibril formation namespace: biological_process def: "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159] comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). synonym: "amyloid fibril assembly" RELATED [] synonym: "amyloid structure assembly" RELATED [] synonym: "amyloid structure formation" RELATED [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0097435 ! supramolecular fiber organization created_by: pr creation_date: 2012-11-27T16:01:02Z [Term] id: GO:1990001 name: inhibition of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137] is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:0097340 ! inhibition of cysteine-type endopeptidase activity created_by: pr creation_date: 2012-12-05T15:42:50Z [Term] id: GO:1990002 name: methylglyoxal reductase (NADPH-dependent, acetol producing) namespace: molecular_function def: "Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+." [EC:1.1.1.-, MetaCyc:RXN0-4281, PMID:16077126, RHEA:27986] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: jl creation_date: 2012-12-05T15:55:06Z [Term] id: GO:1990003 name: IDP phosphatase activity namespace: molecular_function alt_id: GO:0090450 def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:20385596, PMID:22849572] synonym: "IDPase activity" EXACT [] synonym: "inosine diphosphatase activity" EXACT [] synonym: "inosine-diphosphatase activity" EXACT [] xref: EC:3.1.3 xref: Reactome:R-HSA-2509816 "NUDT16 hydrolyses IDP to IMP" is_a: GO:0017110 ! nucleoside-diphosphatase activity is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides created_by: jl creation_date: 2012-12-05T16:46:52Z [Term] id: GO:1990004 name: XDP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: XDP + H2O = XMP + phosphate." [PMID:20385596] is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides created_by: jl creation_date: 2012-12-11T14:01:34Z [Term] id: GO:1990005 name: granular vesicle namespace: cellular_component def: "A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells." [NIF_Subcellular:sao478230652] xref: NIF_Subcellular:sao478230652 is_a: GO:0031410 ! cytoplasmic vesicle created_by: pr creation_date: 2012-12-11T14:51:48Z [Term] id: GO:1990006 name: amorphous vesicle namespace: cellular_component def: "A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway." [NIF_Subcellular:sao1531915298, PMID:11896161] xref: NIF_Subcellular:sao1531915298 is_a: GO:0031410 ! cytoplasmic vesicle created_by: pr creation_date: 2012-12-11T14:55:36Z [Term] id: GO:1990007 name: membrane stack namespace: cellular_component def: "A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures." [ISBN:9780195065718, NIF_Subcellular:sao2114874506] xref: NIF_Subcellular:sao2114874506 is_a: GO:0005783 ! endoplasmic reticulum created_by: pr creation_date: 2012-12-11T14:58:16Z [Term] id: GO:1990008 name: neurosecretory vesicle namespace: cellular_component def: "A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus." [ISBN:0195065719, NIF_Subcellular:sao2031592629] xref: NIF_Subcellular:sao2031592629 is_a: GO:1990005 ! granular vesicle created_by: pr creation_date: 2012-12-12T09:56:14Z [Term] id: GO:1990009 name: retinal cell apoptotic process namespace: biological_process alt_id: GO:0046674 def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] synonym: "induction of retinal programmed cell death" RELATED [] is_a: GO:0006915 ! apoptotic process created_by: pr creation_date: 2012-12-12T10:15:08Z [Term] id: GO:1990010 name: compound eye retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768] is_a: GO:1990009 ! retinal cell apoptotic process created_by: pr creation_date: 2012-12-12T10:21:07Z [Term] id: GO:1990011 name: laminated body namespace: cellular_component def: "Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus." [ISBN:0195065719, NIF_Subcellular:sao506721981] synonym: "laminated inclusion body" EXACT [] xref: NIF_Subcellular:sao506721981 is_a: GO:0016234 ! inclusion body created_by: pr creation_date: 2012-12-12T14:12:21Z [Term] id: GO:1990012 name: complex laminated body namespace: cellular_component def: "A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint." [NIF_Subcellular:nlx_151681] synonym: "CLB" RELATED [] xref: NIF_Subcellular:nlx_151681 is_a: GO:1990011 ! laminated body created_by: pr creation_date: 2012-12-12T14:18:15Z [Term] id: GO:1990013 name: presynaptic grid namespace: cellular_component def: "A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane." [ISBN:0716723808, NIF_Subcellular:sao1730664005] synonym: "pre-synaptic grid" EXACT [] xref: NIF_Subcellular:sao1730664005 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0048786 ! presynaptic active zone created_by: pr creation_date: 2012-12-13T09:00:35Z [Term] id: GO:1990014 name: orthogonal array namespace: cellular_component def: "Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels)." [NIF_Subcellular:sao1747012216, PMID:22718347] synonym: "OAP" RELATED [] synonym: "orthogonal array of particles" EXACT [] synonym: "square array" RELATED [] xref: NIF_Subcellular:sao1747012216 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005886 ! plasma membrane created_by: pr creation_date: 2012-12-13T20:14:15Z [Term] id: GO:1990015 name: ensheathing process namespace: cellular_component def: "A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma." [NIF_Subcellular:sao1376748732] synonym: "ensheathing process of Schwann cell" NARROW [] xref: NIF_Subcellular:sao1376748732 is_a: GO:0110165 ! cellular anatomical entity created_by: pr creation_date: 2012-12-19T09:42:15Z [Term] id: GO:1990016 name: neck portion of tanycyte namespace: cellular_component def: "Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao901230115] synonym: "neck portion" BROAD [] xref: NIF_Subcellular:sao901230115 is_a: GO:0110165 ! cellular anatomical entity created_by: pr creation_date: 2012-12-19T15:17:17Z [Term] id: GO:1990017 name: somatic portion of tanycyte namespace: cellular_component def: "Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao401910342] synonym: "somatic portion" BROAD [] xref: NIF_Subcellular:sao401910342 is_a: GO:0044297 ! cell body created_by: pr creation_date: 2012-12-19T15:19:25Z [Term] id: GO:1990018 name: tail portion of tanycyte namespace: cellular_component def: "Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell." [ISBN:0195065719, NIF_Subcellular:sao1749953771] synonym: "tail portion" BROAD [] xref: NIF_Subcellular:sao1749953771 is_a: GO:0110165 ! cellular anatomical entity created_by: pr creation_date: 2012-12-19T15:21:20Z [Term] id: GO:1990019 name: protein storage vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole." [GOC:tb, PMID:21670741] is_a: GO:0007033 ! vacuole organization created_by: tb creation_date: 2012-12-20T21:00:09Z [Term] id: GO:1990020 name: recurrent axon collateral namespace: cellular_component def: "Axon collateral that ramifies in the area of the soma of the cell of origin." [NIF_Subcellular:sao1642494436] synonym: "recurrent collateral" BROAD [] xref: NIF_Subcellular:sao1642494436 is_a: GO:0044303 ! axon collateral created_by: pr creation_date: 2013-01-10T16:04:31Z [Term] id: GO:1990021 name: Schaffer axon collateral namespace: cellular_component def: "Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1." [NIF_Subcellular:nlx_subcell_20090511] synonym: "Schaffer collateral" BROAD [NIF_Subcellular:sao1950673097] xref: NIF_Subcellular:nlx_subcell_20090511 is_a: GO:0044303 ! axon collateral created_by: pr creation_date: 2013-01-10T16:06:17Z [Term] id: GO:1990022 name: obsolete RNA polymerase III complex import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of an RNA polymerase III complex from the cytoplasm to the nucleus." [GOC:mcc, PMID:23267056] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "DNA-directed RNA polymerase III complex import into nucleus" EXACT [] synonym: "DNA-directed RNA polymerase III complex localization to nucleus" EXACT [] synonym: "RNA polymerase III complex import into nucleus" EXACT [] synonym: "RNA polymerase III complex localisation to nucleus" EXACT [] synonym: "RNA polymerase III complex localization to nucleus" RELATED [] is_obsolete: true consider: GO:0006606 created_by: pr creation_date: 2013-01-15T12:46:26Z [Term] id: GO:1990023 name: mitotic spindle midzone namespace: cellular_component def: "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw] is_a: GO:0051233 ! spindle midzone relationship: part_of GO:0072686 ! mitotic spindle created_by: vw creation_date: 2013-02-05T15:41:48Z [Term] id: GO:1990024 name: C bouton namespace: cellular_component def: "Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons." [NIF_Subcellular:nlx_subcell_100208] xref: NIF_Subcellular:nlx_subcell_100208 is_a: GO:0043195 ! terminal bouton created_by: pr creation_date: 2013-02-06T10:27:41Z [Term] id: GO:1990025 name: F bouton namespace: cellular_component def: "Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles." [NIF_Subcellular:nlx_subcell_100206] xref: NIF_Subcellular:nlx_subcell_100206 is_a: GO:0043195 ! terminal bouton created_by: pr creation_date: 2013-02-06T10:29:42Z [Term] id: GO:1990026 name: hippocampal mossy fiber expansion namespace: cellular_component def: "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002] synonym: "dentate gyrus granule cell axonal bouton" RELATED [] synonym: "dentate gyrus mossy fiber expansion" RELATED [] synonym: "mossy fiber expansion" BROAD [] xref: NIF_Subcellular:nlx_subcell_1005002 is_a: GO:0043195 ! terminal bouton relationship: part_of GO:0097457 ! hippocampal mossy fiber created_by: pr creation_date: 2013-02-06T10:31:59Z [Term] id: GO:1990027 name: S bouton namespace: cellular_component def: "Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles." [NIF_Subcellular:nlx_subcell_100207] xref: NIF_Subcellular:nlx_subcell_100207 is_a: GO:0043195 ! terminal bouton created_by: pr creation_date: 2013-02-06T10:35:12Z [Term] id: GO:1990028 name: intermediate voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Calcium_channel, PMID:16382099] synonym: "R-type calcium channel" RELATED [] is_a: GO:0005245 ! voltage-gated calcium channel activity created_by: pr creation_date: 2013-02-06T20:55:41Z [Term] id: GO:1990029 name: vasomotion namespace: biological_process def: "The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm." [GOC:sl, PMID:14993429, PMID:15678091, PMID:1932763] is_a: GO:0003013 ! circulatory system process created_by: tb creation_date: 2013-02-06T22:30:21Z [Term] id: GO:1990030 name: pericellular basket namespace: cellular_component def: "Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name." [NIF_Subcellular:sao413722576] synonym: "peri cellular basket" EXACT [] synonym: "peri-cellular basket" EXACT [] xref: NIF_Subcellular:sao413722576 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon created_by: pr creation_date: 2013-02-07T12:53:54Z [Term] id: GO:1990031 name: pinceau fiber namespace: cellular_component def: "Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment." [NIF_Subcellular:sao109906988] xref: NIF_Subcellular:sao109906988 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030424 ! axon created_by: pr creation_date: 2013-02-07T12:56:50Z [Term] id: GO:1990032 name: parallel fiber namespace: cellular_component def: "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330] xref: NIF_Subcellular:nlx_330 is_a: GO:0030424 ! axon created_by: pr creation_date: 2013-02-07T12:58:43Z [Term] id: GO:1990033 name: dendritic branch point namespace: cellular_component def: "The part of a dendritic tree where it branches, giving rise to a dendritic branch." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1348591767] synonym: "branch point of dendrite" EXACT [] xref: NIF_Subcellular:sao1348591767 is_a: GO:0061845 ! neuron projection branch point relationship: part_of GO:0097447 ! dendritic tree created_by: pr creation_date: 2013-02-07T13:01:01Z [Term] id: GO:1990034 name: calcium ion export across plasma membrane namespace: biological_process def: "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:2145281] synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281] synonym: "calcium ion export from cell" EXACT [] is_a: GO:0060401 ! cytosolic calcium ion transport is_a: GO:0070588 ! calcium ion transmembrane transport is_a: GO:0140115 ! export across plasma membrane is_a: GO:1901660 ! calcium ion export created_by: mah creation_date: 2013-02-07T13:01:29Z [Term] id: GO:1990036 name: calcium ion import into sarcoplasmic reticulum namespace: biological_process def: "The directed movement of calcium ions into a sarcoplasmic reticulum." [GOC:BHF, PMID:17286271] is_a: GO:0046907 ! intracellular transport is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport is_a: GO:0070509 ! calcium ion import relationship: occurs_in GO:0005737 ! cytoplasm created_by: tb creation_date: 2013-02-07T23:22:27Z [Term] id: GO:1990037 name: Lewy body core namespace: cellular_component def: "The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments." [NIF_Subcellular:sao6587439252] xref: NIF_Subcellular:sao6587439252 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097413 ! Lewy body created_by: pr creation_date: 2013-02-08T12:56:59Z [Term] id: GO:1990038 name: Lewy body corona namespace: cellular_component def: "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747] synonym: "halo" BROAD [] xref: NIF_Subcellular:sao5764355747 is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0097413 ! Lewy body created_by: pr creation_date: 2013-02-08T13:03:27Z [Term] id: GO:1990039 name: hypolemmal cisterna namespace: cellular_component def: "Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer." [ISBN:0195065719, NIF_Subcellular:sao1634374950] synonym: "hypolemmal cisternae" EXACT [] xref: NIF_Subcellular:sao1634374950 is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna created_by: pr creation_date: 2013-02-11T15:04:56Z [Term] id: GO:1990040 name: sub-surface cisterna namespace: cellular_component def: "Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane." [ISBN:0195065719, NIF_Subcellular:sao128470897] synonym: "sub-surface cisternae" EXACT [] xref: NIF_Subcellular:sao128470897 is_a: GO:1990039 ! hypolemmal cisterna created_by: pr creation_date: 2013-02-11T15:10:47Z [Term] id: GO:1990042 name: glycerol dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced." [PMID:22979944] synonym: "glycerol dehydrogenase activity, NAD or NADP as acceptor" EXACT [] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: ramab creation_date: 2013-02-14T00:34:45Z [Term] id: GO:1990043 name: 5' deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997] is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity created_by: pr creation_date: 2013-02-15T12:16:51Z [Term] id: GO:1990044 name: protein localization to lipid droplet namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet." [GOC:sart, PMID:22505614] synonym: "protein localisation to adiposome" EXACT [] synonym: "protein localisation to lipid body" EXACT [] synonym: "protein localisation to lipid droplet" EXACT [] synonym: "protein localisation to lipid particle" EXACT [] synonym: "protein localization to adiposome" EXACT [] synonym: "protein localization to lipid body" EXACT [] synonym: "protein localization to lipid particle" EXACT [] is_a: GO:0033365 ! protein localization to organelle created_by: sart creation_date: 2013-02-15T12:40:57Z [Term] id: GO:1990045 name: sclerotium development namespace: biological_process def: "The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions." [GOC:di, PMID:21148914] is_a: GO:0048856 ! anatomical structure development created_by: pr creation_date: 2013-02-15T15:30:00Z [Term] id: GO:1990046 name: stress-induced mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis." [GOC:lb, PMID:19360003] synonym: "mitochondrial fusion in response to stress" RELATED [] synonym: "SIMH" NARROW [] synonym: "stress-induced mitochondrial hyperfusion" NARROW [] is_a: GO:0008053 ! mitochondrial fusion is_a: GO:0033554 ! cellular response to stress created_by: pr creation_date: 2013-02-15T16:01:55Z [Term] id: GO:1990047 name: spindle matrix namespace: cellular_component def: "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005856 ! cytoskeleton created_by: pr creation_date: 2013-02-18T08:51:47Z [Term] id: GO:1990048 name: anterograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451] subset: goslim_synapse synonym: "anterograde dense core granule trafficking" EXACT [] synonym: "anterograde dense core granule transport" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport [Term] id: GO:1990049 name: retrograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653] subset: goslim_synapse synonym: "retrograde dense core granule trafficking" EXACT [] synonym: "retrograde dense core granule transport" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport created_by: pr creation_date: 2013-02-19T13:31:44Z [Term] id: GO:1990050 name: phosphatidic acid transfer activity namespace: molecular_function def: "Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293] synonym: "intermembrane PA transfer activity" EXACT [] synonym: "intermembrane phosphatidic acid transfer activity" NARROW [] synonym: "phosphatidic acid carrier activity" EXACT [] synonym: "phosphatidic acid transporter activity" BROAD [] is_a: GO:0120014 ! phospholipid transfer activity created_by: ramab creation_date: 2013-02-21T00:45:28Z [Term] id: GO:1990051 name: activation of protein kinase C activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase C." [PMID:3156004] synonym: "PKC activation" EXACT [] synonym: "protein kinase C activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity created_by: sl creation_date: 2013-02-21T19:57:54Z [Term] id: GO:1990052 name: ER to chloroplast lipid transport namespace: biological_process def: "The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast." [PMID:18689504] synonym: "endoplasmic reticulum to chloroplast lipid transport" EXACT [] synonym: "ER to chloroplast lipid trafficking" EXACT [] is_a: GO:0032365 ! intracellular lipid transport is_a: GO:1901965 ! endoplasmic reticulum to chloroplast transport created_by: tb creation_date: 2013-02-22T00:05:23Z [Term] id: GO:1990053 name: DNA-5-methylcytosine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site." [PMID:23316050] is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity created_by: tb creation_date: 2013-02-22T01:09:06Z [Term] id: GO:1990054 name: response to temozolomide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2013-02-22T10:09:44Z [Term] id: GO:1990055 name: phenylacetaldehyde synthase activity namespace: molecular_function def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519] synonym: "aromatic aldehyde synthase" BROAD [] xref: EC:4.1.1.109 is_a: GO:0016831 ! carboxy-lyase activity created_by: tb creation_date: 2013-02-25T20:22:35Z [Term] id: GO:1990056 name: obsolete protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of an amino acid residue in a substrate protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP, thereby targeting the substrate to the proteasomal ubiquitin mediated protein catabolic process" [PMID:21098119, PMID:21993622, PMID:23264631] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process" EXACT [] is_obsolete: true created_by: ramab creation_date: 2013-02-26T21:28:08Z [Term] id: GO:1990057 name: obsolete cell cycle arrest in response to DNA damage stimulus namespace: biological_process def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of DNA damage from environmental insults or errors during metabolism." [GOC:rph, PMID:10630641] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "cell cycle arrest in response to DNA damage stimulus" EXACT [] is_obsolete: true created_by: rph creation_date: 2013-03-06T13:48:44Z [Term] id: GO:1990058 name: fruit replum development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum." [PMID:23133401, PO:0025267] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009791 ! post-embryonic development is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010154 ! fruit development created_by: dhl creation_date: 2013-03-12T21:15:15Z [Term] id: GO:1990059 name: fruit valve development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces." [PMID:23133401, PO:0000033] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009791 ! post-embryonic development is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010154 ! fruit development created_by: dhl creation_date: 2013-03-12T21:21:15Z [Term] id: GO:1990060 name: maltose transport complex namespace: cellular_component def: "Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK." [PMID:18033289] synonym: "maltose ABC transporter complex" EXACT [] synonym: "maltose ATP-binding cassette transporter complex" EXACT [] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: jl creation_date: 2013-03-13T13:52:48Z [Term] id: GO:1990061 name: bacterial degradosome namespace: cellular_component def: "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase." [GOC:bhm, PMID:21805185] is_a: GO:0000177 ! cytoplasmic exosome (RNase complex) relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-03-20T13:51:49Z [Term] id: GO:1990062 name: RPAP3/R2TP/prefoldin-like complex namespace: cellular_component def: "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity." [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846] synonym: "R2TP/prefoldin-like complex" RELATED [] is_a: GO:0032991 ! protein-containing complex created_by: pr creation_date: 2013-03-20T15:31:12Z [Term] id: GO:1990063 name: Bam protein complex namespace: cellular_component def: "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex." [GOC:bhm, PMID:20378773] synonym: "OMP complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane created_by: bhm creation_date: 2013-03-20T15:42:57Z [Term] id: GO:1990064 name: ground tissue pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterning of the ground tissue." [PMID:23444357] synonym: "ground tissue patterning" EXACT [] is_a: GO:0003002 ! regionalization created_by: tb creation_date: 2013-03-21T23:24:44Z [Term] id: GO:1990065 name: Dxr protein complex namespace: cellular_component def: "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)." [GOC:bhm, PMID:15339150] synonym: "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2013-03-27T16:58:54Z [Term] id: GO:1990066 name: energy quenching namespace: biological_process def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence." [PMID:10938857] is_a: GO:0009416 ! response to light stimulus created_by: tb creation_date: 2013-03-27T21:02:00Z [Term] id: GO:1990067 name: intrachromosomal DNA recombination namespace: biological_process def: "The process of DNA recombination occurring within a single chromosome." [PMID:7748165] synonym: "intrastrand DNA recombination" EXACT [] is_a: GO:0006310 ! DNA recombination created_by: tb creation_date: 2013-03-27T21:11:35Z [Term] id: GO:1990068 name: seed dehydration namespace: biological_process def: "The seed development process whose outcome is the drying of a maturing seed." [PMID:20138563] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0010431 ! seed maturation created_by: tb creation_date: 2013-03-27T21:16:03Z [Term] id: GO:1990069 name: stomatal opening namespace: biological_process def: "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [PMID:21749899] is_a: GO:0010118 ! stomatal movement created_by: tb creation_date: 2013-03-27T21:18:48Z [Term] id: GO:1990070 name: TRAPPI protein complex namespace: cellular_component def: "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the \"core subunits\" of all TRAPP complexes in yeast." [GOC:bhm, PMID:20375281, PMID:22669257] synonym: "TRAPP core complex" EXACT [] is_a: GO:0030008 ! TRAPP complex relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment created_by: bhm creation_date: 2013-03-28T14:04:40Z [Term] id: GO:1990071 name: TRAPPII protein complex namespace: cellular_component def: "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257] is_a: GO:0030008 ! TRAPP complex relationship: part_of GO:0005768 ! endosome relationship: part_of GO:0005794 ! Golgi apparatus created_by: bhm creation_date: 2013-03-28T14:24:08Z [Term] id: GO:1990072 name: TRAPPIII protein complex namespace: cellular_component def: "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257] is_a: GO:0030008 ! TRAPP complex relationship: part_of GO:0005794 ! Golgi apparatus created_by: bhm creation_date: 2013-03-28T14:28:59Z [Term] id: GO:1990073 name: perforation plate namespace: cellular_component def: "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations)." [GOC:PO_curators, ISBN:0471245194] comment: Part of a vessel member (PO:0002003). May be simple, with one perforation, or multiperforate, with more than one perforation. Perforation plates are usually on the end walls of a cell, but may also be on the side walls. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005618 ! cell wall created_by: tb creation_date: 2013-03-29T00:53:28Z [Term] id: GO:1990074 name: polyuridylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588] is_a: GO:0006402 ! mRNA catabolic process is_a: GO:0043632 ! modification-dependent macromolecule catabolic process created_by: tb creation_date: 2013-04-16T22:51:46Z [Term] id: GO:1990075 name: periciliary membrane compartment namespace: cellular_component def: "A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis." [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749] synonym: "PCMC" EXACT [] is_a: GO:0098590 ! plasma membrane region created_by: pr creation_date: 2013-04-24T10:14:50Z [Term] id: GO:1990076 name: cell wall polysaccharide catabolic process involved in abscission namespace: biological_process def: "Any cell wall polysaccharide catabolic process that is involved in abscission." [GOC:TermGenie, PMID:23479623] is_a: GO:0044347 ! cell wall polysaccharide catabolic process intersection_of: GO:0044347 ! cell wall polysaccharide catabolic process intersection_of: part_of GO:0009838 ! abscission relationship: part_of GO:0009838 ! abscission created_by: dhl creation_date: 2013-04-25T16:29:43Z [Term] id: GO:1990077 name: primosome complex namespace: cellular_component def: "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207] synonym: "primosome" EXACT [] is_a: GO:0032993 ! protein-DNA complex relationship: part_of GO:0030894 ! replisome created_by: bhm creation_date: 2013-04-26T11:55:28Z [Term] id: GO:1990078 name: replication inhibiting complex namespace: cellular_component def: "A protein complex that inhibits multiple events of replication initiation during one replication cycle." [GOC:bhm, PMID:21708944] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030894 ! replisome created_by: bhm creation_date: 2013-04-26T13:07:03Z [Term] id: GO:1990079 name: cartilage homeostasis namespace: biological_process alt_id: GO:1902094 alt_id: GO:1902095 alt_id: GO:1902096 def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695] synonym: "negative regulation of cartilage homeostasis" RELATED [] synonym: "positive regulation of cartilage homeostasis" RELATED [] synonym: "regulation of cartilage homeostasis" RELATED [] is_a: GO:0001894 ! tissue homeostasis created_by: hjd creation_date: 2013-04-29T20:10:15Z [Term] id: GO:1990080 name: 2-phenylethylamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity." [PMID:16878137] synonym: "beta-phenylethylamine receptor activity" EXACT [] is_a: GO:0008227 ! G protein-coupled amine receptor activity created_by: sp creation_date: 2013-04-30T10:53:19Z [Term] id: GO:1990081 name: trimethylamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine trimethylamine to initiate a change in cell activity." [PMID:16878137] is_a: GO:0001594 ! trace-amine receptor activity created_by: sp creation_date: 2013-04-30T10:57:07Z [Term] id: GO:1990082 name: DnaA-L2 complex namespace: cellular_component def: "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2." [GOC:bhm, PMID:21288885] is_a: GO:1990078 ! replication inhibiting complex created_by: bhm creation_date: 2013-04-30T11:46:41Z [Term] id: GO:1990083 name: DnaA-Hda complex namespace: cellular_component def: "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda." [GOC:bhm, PMID:21708944] is_a: GO:1990078 ! replication inhibiting complex created_by: bhm creation_date: 2013-04-30T11:49:04Z [Term] id: GO:1990084 name: DnaA-Dps complex namespace: cellular_component def: "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps." [GOC:bhm, PMID:18284581] is_a: GO:1990078 ! replication inhibiting complex created_by: bhm creation_date: 2013-04-30T11:50:17Z [Term] id: GO:1990085 name: Hda-beta clamp complex namespace: cellular_component def: "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda." [GOC:bhm, PMID:15150238] synonym: "Hda-DnaN complex" EXACT [] synonym: "Hda-dpo3b complex" EXACT [] is_a: GO:1990078 ! replication inhibiting complex created_by: bhm creation_date: 2013-04-30T11:53:18Z [Term] id: GO:1990086 name: lens fiber cell apoptotic process namespace: biological_process def: "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619] is_a: GO:1904019 ! epithelial cell apoptotic process created_by: hjd creation_date: 2013-05-01T19:09:28Z [Term] id: GO:1990088 name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]." [GOC:hjd, PMID:10077852] xref: EC:2.1.1.246 is_a: GO:0008168 ! methyltransferase activity created_by: hjd creation_date: 2013-05-06T15:07:20Z [Term] id: GO:1990089 name: response to nerve growth factor namespace: biological_process def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805] synonym: "response to nerve growth factor stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: sl creation_date: 2013-05-06T17:08:47Z [Term] id: GO:1990090 name: cellular response to nerve growth factor stimulus namespace: biological_process def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805, Wikipedia:Nerve_growth_factor] synonym: "cellular response to NGF" EXACT [GOC:bf, Wikipedia:Nerve_growth_factor] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:1990089 ! response to nerve growth factor created_by: sl creation_date: 2013-05-06T17:13:36Z [Term] id: GO:1990091 name: sodium-dependent self proteolysis namespace: biological_process def: "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380] is_a: GO:0097264 ! self proteolysis created_by: sl creation_date: 2013-05-06T17:30:23Z [Term] id: GO:1990092 name: calcium-dependent self proteolysis namespace: biological_process def: "The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380] is_a: GO:0097264 ! self proteolysis created_by: sl creation_date: 2013-05-06T17:33:34Z [Term] id: GO:1990093 name: obsolete negative regulation of N-methyl-D-aspartate receptor clustering namespace: biological_process def: "OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "negative regulation of N-methyl-D-aspartate receptor clustering" EXACT [] synonym: "negative regulation of NMDA receptor clustering" EXACT [] is_obsolete: true created_by: sl creation_date: 2013-05-06T17:39:44Z [Term] id: GO:1990094 name: obsolete positive regulation of N-methyl-D-aspartate receptor clustering namespace: biological_process def: "OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "positive regulation of N-methyl-D-aspartate receptor clustering" EXACT [] synonym: "positive regulation of NMDA receptor clustering" EXACT [] is_obsolete: true created_by: sl creation_date: 2013-05-06T17:44:00Z [Term] id: GO:1990095 name: positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:kmv, PMID:16166371] is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress relationship: part_of GO:0034614 ! cellular response to reactive oxygen species created_by: pr creation_date: 2013-05-07T12:10:32Z [Term] id: GO:1990096 name: positive regulation of transcription from RNA polymerase II promoter in response to superoxide namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:kmv, PMID:12869585, PMID:16166371] is_a: GO:1990095 ! positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species relationship: part_of GO:0071451 ! cellular response to superoxide created_by: pr creation_date: 2013-05-07T12:25:34Z [Term] id: GO:1990097 name: SeqA-DNA complex namespace: cellular_component def: "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle." [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570] synonym: "SeqA-dsDNA complex" NARROW [] synonym: "SeqA-hemimethylated DNA complex" NARROW [] synonym: "SeqA-hemimethylation dsDNA complex" NARROW [] is_a: GO:0032993 ! protein-DNA complex created_by: bhm creation_date: 2013-05-13T11:18:11Z [Term] id: GO:1990098 name: core primosome complex namespace: cellular_component def: "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication." [GOC:bhm, PMID:21856207] comment: The core primosome refers to a helicase-primase complex, and should not be confused with the more general GO term 'primosome complex ; GO:1990077'. synonym: "core primosome" EXACT [GOC:bhm] is_a: GO:1990077 ! primosome complex created_by: bhm creation_date: 2013-05-14T10:30:02Z [Term] id: GO:1990099 name: pre-primosome complex namespace: cellular_component def: "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component." [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105] synonym: "pre-priming complex" EXACT [GOC:bhm] synonym: "pre-primosome" EXACT [GOC:bhm, PMID:11994158] synonym: "pre-replication complex" RELATED [GOC:bhm] synonym: "preprimosome" EXACT [GOC:bhm, PMID:2824502] synonym: "preprimosome complex" EXACT [GOC:bhm] synonym: "prereplication complex" EXACT [GOC:bhm] is_a: GO:1990077 ! primosome complex created_by: bhm creation_date: 2013-05-14T10:53:42Z [Term] id: GO:1990100 name: DnaB-DnaC complex namespace: cellular_component def: "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC)." [GOC:bhm, PMID:20129058] comment: DnaB and DnaC may be present in different ratios in different forms of the DnaB-DnaC complex, including a DnaB6-DnaC3 complex active at the oriC, and a DnaB6-DnaC6 complex. synonym: "DnaB6-DnaC3 complex" NARROW [PMID:20129058] synonym: "DnaB6-DnaC6 complex" NARROW [PMID:20129058] synonym: "helicase-loading complex" BROAD [GOC:bhm] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990161 ! DnaB helicase complex relationship: part_of GO:1990077 ! primosome complex created_by: bhm creation_date: 2013-05-14T12:02:22Z [Term] id: GO:1990101 name: DnaA-oriC complex namespace: cellular_component def: "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle." [GOC:bhm, PMID:19833870] synonym: "DnaA-DNA complex" BROAD [GOC:bhm] is_a: GO:1990077 ! primosome complex created_by: bhm creation_date: 2013-05-14T12:07:04Z [Term] id: GO:1990102 name: DnaA-DiaA complex namespace: cellular_component def: "A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA." [GOC:bhm, PMID:15326179, PMID:17699754] synonym: "DnaA-DiaA-DNA complex" EXACT [GOC:bhm] is_a: GO:1990077 ! primosome complex relationship: has_part GO:1990101 ! DnaA-oriC complex relationship: has_part GO:1990125 ! DiaA complex created_by: bhm creation_date: 2013-05-14T12:33:59Z [Term] id: GO:1990103 name: DnaA-HU complex namespace: cellular_component def: "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC." [GOC:bhm, PMID:18179598] synonym: "DnaA-HU-DNA complex" EXACT [GOC:bhm] is_a: GO:1990077 ! primosome complex created_by: bhm creation_date: 2013-05-14T12:36:39Z [Term] id: GO:1990104 name: DNA bending complex namespace: cellular_component def: "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674] synonym: "histone-like DNA binding complex" NARROW [GOC:bhm] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2013-05-20T09:29:06Z [Term] id: GO:1990105 name: obsolete regulation of voltage-gated potassium channel activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity." [PMID:19219384] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of voltage-gated potassium channel activity" EXACT [] is_obsolete: true created_by: sl creation_date: 2013-05-21T15:12:06Z [Term] id: GO:1990107 name: thiazole synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O." [EC:2.8.1.10, GOC:cjk, PMID:22031445, RHEA:26297] comment: H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis. synonym: "1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity" EXACT [] is_a: GO:0016783 ! sulfurtransferase activity relationship: part_of GO:0009228 ! thiamine biosynthetic process created_by: pr creation_date: 2013-05-28T12:36:04Z [Term] id: GO:1990108 name: protein linear deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein." [PMID:23708998] is_a: GO:0016579 ! protein deubiquitination created_by: sp creation_date: 2013-05-29T05:58:49Z [Term] id: GO:1990109 name: rejection of pollen from other species namespace: biological_process def: "The process involved in the rejection of pollen of one species by cells in the stigma of another species." [PMID:21205670] synonym: "unilateral interspecific incompatibility" EXACT [] is_a: GO:0044419 ! interspecies interaction between organisms is_a: GO:0044703 ! multi-organism reproductive process relationship: part_of GO:0009875 ! pollen-pistil interaction created_by: tb creation_date: 2013-05-29T21:12:09Z [Term] id: GO:1990110 name: callus formation namespace: biological_process def: "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042060 ! wound healing created_by: tb creation_date: 2013-05-29T22:02:52Z [Term] id: GO:1990111 name: spermatoproteasome complex namespace: cellular_component def: "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." [GOC:sp, PMID:23706739] is_a: GO:0000502 ! proteasome complex created_by: sp creation_date: 2013-05-31T11:56:52Z [Term] id: GO:1990112 name: RQC complex namespace: cellular_component def: "A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563] synonym: "ribosome quality control complex" EXACT [PMID:23178123, PMID:23232563] synonym: "ribosome-bound quality control complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2013-05-31T21:42:43Z [Term] id: GO:1990113 name: RNA polymerase I assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex." [GOC:rb, PMID:23459708] synonym: "DNA-directed RNA polymerase I complex assembly" EXACT [] synonym: "RNA Polymerase I complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: rb creation_date: 2013-05-31T21:44:41Z [Term] id: GO:1990114 name: RNA polymerase II core complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." [GOC:rb, PMID:23459708] synonym: "DNA-directed RNA polymerase II, core complex assembly" EXACT [] synonym: "RNA Polymerase II assembly" BROAD [] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: rb creation_date: 2013-05-31T21:46:42Z [Term] id: GO:1990115 name: RNA polymerase III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708] synonym: "DNA-directed RNA polymerase III complex assembly" EXACT [] synonym: "RNA Polymerase III complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: rb creation_date: 2013-05-31T21:49:19Z [Term] id: GO:1990116 name: ribosome-associated ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411] synonym: "RAD" BROAD [] synonym: "ribosome-associated degradation" BROAD [] synonym: "ribosome-associated ubiquitin-dependent protein breakdown" EXACT [] synonym: "ribosome-associated ubiquitin-dependent protein catabolism" EXACT [] synonym: "ribosome-associated ubiquitin-dependent protein degradation" EXACT [] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: pr creation_date: 2013-06-05T11:46:01Z [Term] id: GO:1990117 name: B cell receptor apoptotic signaling pathway namespace: biological_process def: "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043] synonym: "B cell receptor extrinsic apoptotic signaling pathway" EXACT [] synonym: "extrinsic apoptotic signaling pathway via B cell antigen receptor" RELATED [] synonym: "extrinsic apoptotic signaling pathway via BCR" RELATED [] is_a: GO:0050853 ! B cell receptor signaling pathway is_a: GO:0097191 ! extrinsic apoptotic signaling pathway relationship: part_of GO:0001783 ! B cell apoptotic process created_by: pr creation_date: 2013-06-06T15:15:17Z [Term] id: GO:1990119 name: ATP-dependent RNA helicase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of ATP-dependent RNA helicase." [GOC:rb, PMID:23721653] is_a: GO:0042030 ! ATPase inhibitor activity relationship: negatively_regulates GO:0003724 ! RNA helicase activity created_by: rb creation_date: 2013-06-11T21:14:38Z [Term] id: GO:1990120 name: messenger ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653] synonym: "messenger ribonucleoprotein assembly" RELATED [] synonym: "mRNA-protein complex assembly" EXACT [GOC:bf] synonym: "mRNP assembly" EXACT [GOC:rb] synonym: "mRNP complex assembly" EXACT [GOC:bf] is_a: GO:0022618 ! ribonucleoprotein complex assembly created_by: rb creation_date: 2013-06-11T21:18:20Z [Term] id: GO:1990121 name: H-NS complex namespace: cellular_component def: "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA." [GOC:bhm, PMID:12592399] synonym: "DNA-binding protein H-NS complex" EXACT [] synonym: "histone-like protein H-NS complex" EXACT [] is_a: GO:1990104 ! DNA bending complex relationship: part_of GO:0005829 ! cytosol relationship: part_of GO:0043590 ! bacterial nucleoid created_by: bhm creation_date: 2013-06-12T10:08:31Z [Term] id: GO:1990124 name: messenger ribonucleoprotein complex namespace: cellular_component def: "A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786] synonym: "messenger ribonucleoprotein particle" RELATED [PMID:21915786] synonym: "mRNA-protein complex" EXACT [PMID:21915786] synonym: "mRNP" EXACT [PMID:21915786] synonym: "mRNP complex" EXACT [PMID:15574591, PMID:21915786] is_a: GO:1990904 ! ribonucleoprotein complex created_by: bf creation_date: 2013-06-13T09:20:52Z [Term] id: GO:1990125 name: DiaA complex namespace: cellular_component def: "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation." [GOC:bhm, PMID:17699754] synonym: "DiaA homotetramer" EXACT [GOC:bf, PMID:17699754] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2013-06-13T14:03:54Z [Term] id: GO:1990126 name: retrograde transport, endosome to plasma membrane namespace: biological_process def: "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:23563491] is_a: GO:0016197 ! endosomal transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane created_by: sp creation_date: 2013-06-18T10:52:50Z [Term] id: GO:1990127 name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered." [GOC:krc, GOC:mtg_apoptosis, PMID:16571598] is_a: GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator created_by: pr creation_date: 2013-06-19T13:55:06Z [Term] id: GO:1990128 name: obsolete pre-primosome complex involved in replication initiation namespace: cellular_component def: "OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication." [GOC:bhm, PMID:21856207] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "pre-primosome complex involved in replication initiation" EXACT [] is_obsolete: true created_by: bhm creation_date: 2013-06-24T10:29:39Z [Term] id: GO:1990129 name: obsolete pre-primosome complex involved in replication restart namespace: cellular_component def: "OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired." [GOC:bhm, PMID:17139333] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "pre-primosome complex involved in replication restart" EXACT [] is_obsolete: true created_by: bhm creation_date: 2013-06-24T10:36:30Z [Term] id: GO:1990130 name: GATOR1 complex namespace: cellular_component def: "A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3." [GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:28199306] synonym: "IML1 complex" EXACT [] synonym: "SEACIT complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0035859 ! Seh1-associated complex created_by: rb creation_date: 2013-06-25T17:34:40Z [Term] id: GO:1990131 name: Gtr1-Gtr2 GTPase complex namespace: cellular_component def: "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2013-06-25T20:39:16Z [Term] id: GO:1990132 name: obsolete release of misfolded protein from chaperone namespace: biological_process def: "OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery." [GOC:rb, PMID:23530227] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "release of misfolded protein from chaperone" EXACT [] is_obsolete: true created_by: rb creation_date: 2013-06-25T21:56:37Z [Term] id: GO:1990133 name: molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex namespace: cellular_component def: "A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, pmid:11713534, pmid:16669776] is_a: GO:1902503 ! adenylyltransferase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-06-26T10:54:21Z [Term] id: GO:1990134 name: epithelial cell apoptotic process involved in palatal shelf morphogenesis namespace: biological_process def: "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf." [GOC:dph, GOC:mtg_apoptosis, PMID:16607638] is_a: GO:0060561 ! apoptotic process involved in morphogenesis is_a: GO:1904019 ! epithelial cell apoptotic process relationship: part_of GO:0062009 ! secondary palate development created_by: dph creation_date: 2013-06-26T11:56:00Z [Term] id: GO:1990135 name: flavonoid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative." [PMID:23611783] is_a: GO:0008146 ! sulfotransferase activity created_by: tb creation_date: 2013-06-28T22:07:27Z [Term] id: GO:1990136 name: linoleate 9S-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate." [EC:1.13.11.58, GOC:rph, RHEA:30291] synonym: "9-lipoxygenase activity" RELATED [] synonym: "9S-lipoxygenase activity" RELATED [] synonym: "linoleate 9-lipoxygenase activity" RELATED [] synonym: "linoleate:oxygen 9S-oxidoreductase activity" EXACT [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen created_by: pr creation_date: 2013-07-03T12:20:57Z [Term] id: GO:1990137 name: plant seed peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH." [PMID:19467604] synonym: "peroxygenase activity" RELATED [PMID:19467604] xref: EC:1.11.2.3 xref: MetaCyc:RXN-11819 is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor created_by: tb creation_date: 2013-07-03T12:49:20Z [Term] id: GO:1990138 name: neuron projection extension namespace: biological_process def: "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009] synonym: "neurite extension" NARROW [] synonym: "neuron process extension" EXACT [] synonym: "neuron protrusion extension" EXACT [] synonym: "neuronal cell projection extension" EXACT [] is_a: GO:0048588 ! developmental cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0048812 ! neuron projection morphogenesis created_by: pr creation_date: 2013-07-08T08:40:45Z [Term] id: GO:1990139 name: protein localization to nuclear periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609] is_a: GO:0034504 ! protein localization to nucleus created_by: mah creation_date: 2013-07-09T13:35:49Z [Term] id: GO:1990140 name: MPT synthase complex namespace: cellular_component def: "A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11135669, PMID:16669776, Reactome:R-HSA-947581] synonym: "molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex" RELATED [] is_a: GO:1990228 ! sulfurtransferase complex created_by: pr creation_date: 2013-07-11T08:32:29Z [Term] id: GO:1990141 name: chromatin silencing at centromere outer repeat region namespace: biological_process def: "Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin." [PMID:21847092] synonym: "chromatin silencing at pericentric region" RELATED [GOC:mah] is_a: GO:0030702 ! chromatin silencing at centromere intersection_of: GO:0006342 ! chromatin silencing intersection_of: occurs_in GO:0034507 ! chromosome, centromeric outer repeat region relationship: occurs_in GO:0034507 ! chromosome, centromeric outer repeat region created_by: mah creation_date: 2013-07-17T15:21:38Z [Term] id: GO:1990142 name: envenomation resulting in hemolysis in other organism namespace: biological_process def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism." [PMID:21590705] is_a: GO:0044649 ! envenomation resulting in cytolysis in other organism created_by: sp creation_date: 2013-07-18T10:46:03Z [Term] id: GO:1990143 name: CoA-synthesizing protein complex namespace: cellular_component def: "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway." [GOC:rb, PMID:23789928] synonym: "CoA-SPC" EXACT [] synonym: "coenzyme A-synthesizing protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2013-07-18T22:30:20Z [Term] id: GO:1990144 name: intrinsic apoptotic signaling pathway in response to hypoxia namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456] is_a: GO:0097193 ! intrinsic apoptotic signaling pathway relationship: part_of GO:0071456 ! cellular response to hypoxia created_by: pr creation_date: 2013-07-23T10:18:10Z [Term] id: GO:1990145 name: maintenance of translational fidelity namespace: biological_process def: "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template." [GOC:hjd, ISBN:9781936113460, PMID:21841312] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation created_by: hjd creation_date: 2013-07-24T19:30:09Z [Term] id: GO:1990146 name: protein localization to rhabdomere namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687] is_a: GO:0034613 ! cellular protein localization created_by: sart creation_date: 2013-07-25T11:24:49Z [Term] id: GO:1990147 name: talin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types." [GOC:hjd, PMID:23372168] is_a: GO:0008092 ! cytoskeletal protein binding created_by: hjd creation_date: 2013-07-25T19:49:53Z [Term] id: GO:1990148 name: glutamate dehydrogenase complex namespace: cellular_component def: "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies." [GOC:bhm, PMID:22393408, PMID:23412807] synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex" RELATED [] synonym: "glutamate dehydrogenase (NADP+) complex" RELATED [] synonym: "glutamic acid dehydrogenase complex" RELATED [] synonym: "glutamic dehydrogenase complex" RELATED [] synonym: "L-glutamate dehydrogenase complex" RELATED [] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating) complex" RELATED [] synonym: "L-glutamic acid dehydrogenase complex" RELATED [] synonym: "NAD(P)-glutamate dehydrogenase complex" RELATED [] synonym: "NAD(P)H-dependent glutamate dehydrogenase complex" RELATED [] is_a: GO:1990204 ! oxidoreductase complex created_by: pr creation_date: 2013-07-26T10:14:15Z [Term] id: GO:1990149 name: obsolete COPI vesicle coating namespace: biological_process def: "OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:rb, PMID:11970962] comment: This term was obsoleted at the TermGenie Gatekeeper stage because COPI vesicles are formed on Golgi membranes, and the existing term 'COPI coating of Golgi vesicle ; GO:0048205' describes this process. synonym: "COPI vesicle coating" EXACT [] is_obsolete: true created_by: rb creation_date: 2013-07-29T22:09:37Z [Term] id: GO:1990150 name: VEGF-A complex namespace: cellular_component def: "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase." [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168] synonym: "vascular endothelial growth factor A complex" EXACT [GOC:bhm] is_a: GO:0036454 ! growth factor complex created_by: bhm creation_date: 2013-07-30T13:24:41Z [Term] id: GO:1990151 name: protein localization to cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263] synonym: "protein localisation to cell tip" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization created_by: mah creation_date: 2013-07-31T14:56:40Z [Term] id: GO:1990152 name: protein localization to telomeric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location in telomeric heterochromatin." [PMID:21300781] synonym: "protein localisation to telomeric heterochromatin" EXACT [GOC:mah] is_a: GO:0070198 ! protein localization to chromosome, telomeric region is_a: GO:0097355 ! protein localization to heterochromatin created_by: mah creation_date: 2013-07-31T15:04:26Z [Term] id: GO:1990153 name: maintenance of protein localization to heterochromatin namespace: biological_process def: "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781] synonym: "maintenance of protein localisation to heterochromatin" EXACT [GOC:mah] synonym: "maintenance of protein location in heterochromatin" RELATED [GOC:mah] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0097355 ! protein localization to heterochromatin created_by: mah creation_date: 2013-07-31T15:11:37Z [Term] id: GO:1990154 name: enzyme IIA-maltose transporter complex namespace: cellular_component def: "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter." [GOC:bf, GOC:bhm, PMID:23770568] synonym: "EIIA(Glc)-MalFGK2 complex" EXACT [PMID:23770568] synonym: "EIIA(Glc)-maltose transporter complex" EXACT [PMID:23770568] synonym: "maltose transporter inhibitor complex" RELATED [GOC:bhm] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex relationship: has_part GO:1990060 ! maltose transport complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2013-08-01T09:27:25Z [Term] id: GO:1990155 name: Dsc E3 ubiquitin ligase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507] synonym: "Dsc complex assembly" EXACT [PMID:23760507] is_a: GO:0034622 ! cellular protein-containing complex assembly created_by: mah creation_date: 2013-08-01T14:19:19Z [Term] id: GO:1990156 name: DnaB-DnaG complex namespace: cellular_component def: "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes." [GOC:bhm, PMID:14557266] synonym: "DnaB-DnaG primosome complex" RELATED [GOC:bhm] is_a: GO:0033202 ! DNA helicase complex relationship: has_part GO:1990161 ! DnaB helicase complex relationship: part_of GO:1990098 ! core primosome complex created_by: bhm creation_date: 2013-08-02T09:50:54Z [Term] id: GO:1990157 name: DnaA-DnaB-DnaC complex namespace: cellular_component def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation." [GOC:bhm, PMID:20129058] is_a: GO:1990099 ! pre-primosome complex relationship: has_part GO:1990100 ! DnaB-DnaC complex created_by: bhm creation_date: 2013-08-02T11:42:27Z [Term] id: GO:1990158 name: DnaB-DnaC-DnaT-PriA-PriB complex namespace: cellular_component def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105] synonym: "DnaB-DnaC-DnaT-PriA-PriB preprimosome" EXACT [PMID:8663105] synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] is_a: GO:1990099 ! pre-primosome complex relationship: has_part GO:1990100 ! DnaB-DnaC complex created_by: bhm creation_date: 2013-08-02T11:52:55Z [Term] id: GO:1990159 name: DnaB-DnaC-DnaT-PriA-PriC complex namespace: cellular_component def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105] synonym: "DnaB-DnaC-DnaT-PriA-PriC preprimosome" EXACT [PMID:8663105] synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] is_a: GO:1990099 ! pre-primosome complex relationship: has_part GO:1990100 ! DnaB-DnaC complex created_by: bhm creation_date: 2013-08-02T11:58:16Z [Term] id: GO:1990160 name: DnaB-DnaC-Rep-PriC complex namespace: cellular_component def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:19941825, PMID:8663105] synonym: "DnaB-DnaC-Rep-PriC preprimosome" EXACT [PMID:8663105] synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] is_a: GO:1990099 ! pre-primosome complex relationship: has_part GO:1990100 ! DnaB-DnaC complex created_by: bhm creation_date: 2013-08-02T12:05:25Z [Term] id: GO:1990161 name: DnaB helicase complex namespace: cellular_component def: "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair." [GOC:bhm, PMID:17947583] synonym: "DnaB hexamer" EXACT [GOC:bhm] is_a: GO:0033202 ! DNA helicase complex created_by: bhm creation_date: 2013-08-02T15:55:48Z [Term] id: GO:1990162 name: histone deacetylase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein." [GOC:al, PMID:23771057] is_a: GO:0004407 ! histone deacetylase activity relationship: part_of GO:1990596 ! histone H3-K4 deacetylation created_by: pr creation_date: 2013-08-06T08:48:44Z [Term] id: GO:1990164 name: histone H2A phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121] is_a: GO:0016572 ! histone phosphorylation created_by: mah creation_date: 2013-08-08T11:13:25Z [Term] id: GO:1990165 name: single-strand break-containing DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA containing single-strand breaks (SSBs)." [GOC:al, PMID:21984210] synonym: "single-strand break-containing damaged DNA binding" EXACT [] synonym: "SSB-containing DNA binding" EXACT [] is_a: GO:0003684 ! damaged DNA binding created_by: pr creation_date: 2013-08-08T11:16:04Z [Term] id: GO:1990166 name: protein localization to site of double-strand break namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121] synonym: "protein localisation to site of double-strand break" EXACT [GOC:mah] synonym: "protein localization to double-strand break site" EXACT [GOC:mah] synonym: "protein localization to site of DSB" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome created_by: mah creation_date: 2013-08-08T11:27:00Z [Term] id: GO:1990167 name: protein K27-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein." [PMID:23827681] is_a: GO:0016579 ! protein deubiquitination created_by: sp creation_date: 2013-08-14T11:15:24Z [Term] id: GO:1990168 name: protein K33-linked deubiquitination namespace: biological_process def: "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681] is_a: GO:0016579 ! protein deubiquitination created_by: sp creation_date: 2013-08-14T11:19:39Z [Term] id: GO:1990169 name: stress response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus." [GOC:kmv, PMID:23437011] synonym: "response to copper ion stress" EXACT [] synonym: "response to copper toxicity" RELATED [] synonym: "stress response to copper" BROAD [] is_a: GO:0046688 ! response to copper ion is_a: GO:0097501 ! stress response to metal ion created_by: pr creation_date: 2013-08-14T12:52:05Z [Term] id: GO:1990170 name: stress response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus." [GOC:kmv] synonym: "response to cadmium ion stress" EXACT [] synonym: "response to cadmium toxicity" RELATED [] synonym: "stress response to cadmium" BROAD [] is_a: GO:0046686 ! response to cadmium ion is_a: GO:0097501 ! stress response to metal ion created_by: pr creation_date: 2013-08-14T12:55:45Z [Term] id: GO:1990171 name: SCF complex disassembly in response to cadmium stress namespace: biological_process def: "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress." [GOC:rb, PMID:23000173] is_a: GO:0032984 ! protein-containing complex disassembly relationship: part_of GO:0071276 ! cellular response to cadmium ion created_by: rb creation_date: 2013-08-15T22:38:06Z [Term] id: GO:1990172 name: G protein-coupled receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor." [PMID:12142540, PMID:23954414] synonym: "G-protein coupled receptor catabolic process" EXACT [] is_a: GO:0032801 ! receptor catabolic process is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway created_by: sp creation_date: 2013-08-22T10:16:58Z [Term] id: GO:1990173 name: protein localization to nucleoplasm namespace: biological_process alt_id: GO:0032066 def: "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] comment: Merged with nucleolus to nucleoplasm transport, see https://github.com/geneontology/go-ontology/issues/14690 synonym: "nucleolus to nucleoplasm transport" RELATED [] synonym: "protein localisation to nucleoplasm" EXACT [GOC:mah] is_a: GO:0034504 ! protein localization to nucleus created_by: mah creation_date: 2013-08-23T15:01:16Z [Term] id: GO:1990174 name: phosphodiesterase decapping endonuclease activity namespace: molecular_function def: "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481] synonym: "G(5')pppN pyrophosphatase activity" RELATED [] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters created_by: tb creation_date: 2013-08-26T17:51:00Z [Term] id: GO:1990175 name: EH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R." [GOC:hjd, PMID:11911876, PMID:21115825] is_a: GO:0019904 ! protein domain specific binding created_by: hjd creation_date: 2013-08-27T20:14:56Z [Term] id: GO:1990176 name: MalFGK2 complex namespace: cellular_component def: "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG." [GOC:bhm, PMID:19250913] comment: The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060. synonym: "MalF-MalG-MalK(2) complex" EXACT [GOC:bf] synonym: "MalF-MalG-MalK-MalK complex" EXACT [GOC:bf] synonym: "MalFGK(2) complex" EXACT [PMID:19250913] synonym: "maltose transport complex, core subunit" EXACT [GOC:bhm] synonym: "maltose transport MalFGK2 complex" EXACT [GOC:bhm] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:1990060 ! maltose transport complex created_by: bhm creation_date: 2013-08-30T11:10:14Z [Term] id: GO:1990177 name: IHF-DNA complex namespace: cellular_component def: "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid." [GOC:bhm, PMID:17097674] synonym: "IHF complex" EXACT [GOC:bhm] synonym: "IHFa-IHFb-DNA complex" EXACT [GOC:bhm] is_a: GO:0032993 ! protein-DNA complex is_a: GO:1990104 ! DNA bending complex relationship: part_of GO:0043590 ! bacterial nucleoid created_by: bhm creation_date: 2013-08-30T12:22:54Z [Term] id: GO:1990178 name: HU-DNA complex namespace: cellular_component def: "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure." [GOC:bhm, PMID:17360520] synonym: "HU complex" BROAD [GOC:bhm] is_a: GO:0032993 ! protein-DNA complex is_a: GO:1990104 ! DNA bending complex relationship: part_of GO:0043590 ! bacterial nucleoid created_by: bhm creation_date: 2013-08-30T13:06:53Z [Term] id: GO:1990179 name: protein localization to actomyosin contractile ring namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808] synonym: "protein localisation to actomyosin contractile ring" EXACT [] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072741 ! protein localization to cell division site is_a: GO:1903119 ! protein localization to actin cytoskeleton created_by: mah creation_date: 2013-08-30T16:13:54Z [Term] id: GO:1990180 name: mitochondrial tRNA 3'-end processing namespace: biological_process def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301] synonym: "tRNA 3' processing in mitochondria" EXACT [GOC:TermGenie] synonym: "tRNA 3' processing in mitochondrion" EXACT [GOC:TermGenie] synonym: "tRNA 3'-end processing in mitochondria" EXACT [GOC:TermGenie] is_a: GO:0000965 ! mitochondrial RNA 3'-end processing is_a: GO:0042780 ! tRNA 3'-end processing is_a: GO:0090646 ! mitochondrial tRNA processing intersection_of: GO:0042780 ! tRNA 3'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: mah creation_date: 2013-08-30T16:17:36Z [Term] id: GO:1990181 name: acetyl-CoA biosynthetic process from pantothenate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA." [GOC:mah, PMID:23091701] synonym: "acetyl-CoA anabolism from pantothenate" EXACT [] synonym: "acetyl-CoA formation from pantothenate" RELATED [] synonym: "acetyl-CoA synthesis from pantothenate" RELATED [] is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0015939 ! pantothenate metabolic process created_by: mah creation_date: 2013-08-30T16:20:44Z [Term] id: GO:1990182 name: exosomal secretion namespace: biological_process def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898] synonym: "exosomal protein secretion" NARROW [PMID:18617898] synonym: "exosomal secretory pathway" EXACT [PMID:18617898] synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd] synonym: "multi-vesicular body fusion with plasma membrane" EXACT [] synonym: "secretion of exosome" EXACT [PMID:18617898] is_a: GO:0006887 ! exocytosis relationship: part_of GO:0097734 ! extracellular exosome biogenesis created_by: hjd creation_date: 2013-09-04T21:08:14Z [Term] id: GO:1990183 name: lymphatic vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the lymphatic vasculature." [PMID:21576390] is_a: GO:0003018 ! vascular process in circulatory system created_by: sl creation_date: 2013-09-10T22:26:40Z [Term] id: GO:1990184 name: amino acid transport complex namespace: cellular_component def: "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347] is_a: GO:0098797 ! plasma membrane protein complex created_by: jl creation_date: 2013-09-11T15:02:16Z [Term] id: GO:1990185 name: regulation of lymphatic vascular permeability namespace: biological_process def: "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid." [PMID:23897233] is_a: GO:0043114 ! regulation of vascular permeability is_a: GO:1990183 ! lymphatic vascular process in circulatory system created_by: sl creation_date: 2013-09-11T15:36:22Z [Term] id: GO:1990186 name: regulation of lymphatic vessel size namespace: biological_process def: "Any process that modulates the size of lymphatic vessels." [PMID:23897233] synonym: "regulation of collecting lymphatic vessel size" NARROW [] is_a: GO:0090066 ! regulation of anatomical structure size is_a: GO:1990183 ! lymphatic vascular process in circulatory system created_by: sl creation_date: 2013-09-11T15:41:16Z [Term] id: GO:1990187 name: obsolete protein localization to mRNA namespace: biological_process def: "OBSOLETE. A process in which a protein is transported to, or maintained at mRNA." [GOC:rb, PMID:22890846] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "protein localization to mRNA" EXACT [] is_obsolete: true created_by: rb creation_date: 2013-09-11T18:19:20Z [Term] id: GO:1990188 name: euchromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512] is_a: GO:0003682 ! chromatin binding created_by: tb creation_date: 2013-09-11T19:18:38Z [Term] id: GO:1990189 name: peptide-serine-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279] is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity created_by: tb creation_date: 2013-09-11T20:13:40Z [Term] id: GO:1990190 name: peptide-glutamate-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279] is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity created_by: tb creation_date: 2013-09-11T20:21:25Z [Term] id: GO:1990191 name: cobalamin transport complex namespace: cellular_component def: "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD." [GOC:bhm, PMID:22569249] synonym: "BtuCDF complex" EXACT [] synonym: "cobalamin-transporting BtuCDF complex" EXACT [] synonym: "vitamin B12 transport complex" EXACT [] synonym: "vitamin B12-transporting BtuCDF complex" EXACT [] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex relationship: has_part GO:1990193 ! BtuCD complex created_by: bhm creation_date: 2013-09-12T14:20:19Z [Term] id: GO:1990192 name: collecting lymphatic vessel constriction namespace: biological_process def: "A decrease in the diameter of collecting lymphatic vessels." [PMID:23322290] synonym: "lymphatic vessel myogenic constriction" EXACT [] is_a: GO:1990186 ! regulation of lymphatic vessel size created_by: sl creation_date: 2013-09-12T14:46:05Z [Term] id: GO:1990193 name: BtuCD complex namespace: cellular_component def: "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer." [GOC:bhm, PMID:22569249] synonym: "BtuC-BtuD complex" EXACT [] synonym: "cobalamin transport complex, core subunit" EXACT [] synonym: "vitamin B12 transport complex, core subunit" EXACT [] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex created_by: bhm creation_date: 2013-09-12T14:58:56Z [Term] id: GO:1990194 name: cytoplasmic U snRNP body assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282] synonym: "U body assembly" RELATED [] is_a: GO:0022618 ! ribonucleoprotein complex assembly created_by: tb creation_date: 2013-09-12T21:54:20Z [Term] id: GO:1990195 name: macrolide transmembrane transporter complex namespace: cellular_component def: "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725] synonym: "AcrAB-TolC complex" NARROW [] synonym: "MacAB-TolC complex" NARROW [] synonym: "macrolide transporter" RELATED [] synonym: "macrolide transporter complex" BROAD [] is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2013-09-23T11:22:26Z [Term] id: GO:1990196 name: MacAB-TolC complex namespace: cellular_component def: "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725] synonym: "macrolide transporter MacAB-TolC complex" EXACT [] is_a: GO:1990195 ! macrolide transmembrane transporter complex created_by: bhm creation_date: 2013-09-23T11:29:28Z [Term] id: GO:1990197 name: ATP-dependent methionine-importing complex namespace: cellular_component def: "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner." [GOC:bhm, PMID:22095702] synonym: "ATP-binding cassette (ABC) methionine importer complex" EXACT [] synonym: "ATP-dependent methionine importer complex" EXACT [] synonym: "ATP-dependent methionine importing complex" EXACT [] synonym: "methionine transport complex" BROAD [] synonym: "methionine transporter" RELATED [] synonym: "methionine transporter complex" BROAD [] synonym: "methionine transporter complex, ATP-dependent" BROAD [] synonym: "MetNI complex" NARROW [] synonym: "MetNI transport complex" NARROW [] synonym: "MetNI transporter" RELATED [] synonym: "MetNI transporter complex" NARROW [] synonym: "MetNIQ complex" NARROW [] synonym: "MetNIQ transport complex" NARROW [] synonym: "MetNIQ transporter" RELATED [] synonym: "MetNIQ transporter complex" RELATED [] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex is_a: GO:1902509 ! methionine-importing complex created_by: bhm creation_date: 2013-09-26T09:38:26Z [Term] id: GO:1990198 name: ModE complex namespace: cellular_component def: "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism." [GOC:bhm, PMID:12581638] synonym: "ModE dimer" EXACT [GOC:bhm] is_a: GO:0044797 ! cytoplasmic transcription factor complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-01T07:28:52Z [Term] id: GO:1990199 name: MsbA transporter complex namespace: cellular_component def: "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD)." [GOC:bhm, PMID:18024585] synonym: "MsbA complex" EXACT [GOC:bhm] synonym: "MsbA dimer" EXACT [GOC:bhm] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex created_by: bhm creation_date: 2013-10-01T07:49:41Z [Term] id: GO:1990200 name: SsuD-SsuE complex namespace: cellular_component def: "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation." [GOC:bhm, PMID:16997955] synonym: "two-component alkanesulfonate monooxygenase system" RELATED [GOC:bhm] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990201 ! alkanesulfonate monooxygenase complex relationship: has_part GO:1990202 ! FMN reductase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-03T12:59:26Z [Term] id: GO:1990201 name: alkanesulfonate monooxygenase complex namespace: cellular_component def: "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer." [GOC:bhm, PMID:10480865, PMID:16997955] synonym: "SsuD complex" NARROW [GOC:bhm] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-03T14:55:08Z [Term] id: GO:1990202 name: FMN reductase complex namespace: cellular_component def: "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer." [GOC:bhm, PMID:10480865, PMID:16997955] synonym: "flavin oxidoreductase complex, NAD(P)H-dependent" BROAD [GOC:bhm] synonym: "FMN oxidoreductase complex, NAD(P)H-dependent" RELATED [GOC:bhm] synonym: "FMN reductase complex, NAD(P)H-dependent" EXACT [GOC:bhm] synonym: "SsuE complex" NARROW [GOC:bhm] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-03T15:07:20Z [Term] id: GO:1990203 name: MdtBC Complex namespace: cellular_component def: "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane." [GOC:bhm, PMID:20038594] synonym: "multidrug efflux pump MdtBC" EXACT [GOC:bhm] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2013-10-04T21:22:18Z [Term] id: GO:1990204 name: oxidoreductase complex namespace: cellular_component def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] subset: goslim_metagenomics synonym: "oxidation-reduction complex" EXACT [] synonym: "redox complex" EXACT [] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2013-10-07T08:24:47Z [Term] id: GO:1990205 name: taurine dioxygenase complex namespace: cellular_component def: "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD." [GOC:bhm, PMID:12741810] synonym: "2-aminoethanesulfonate dioxygenase complex" EXACT [] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase complex" EXACT [] synonym: "TauD complex" NARROW [] is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-07T13:03:15Z [Term] id: GO:1990206 name: jasmonyl-Ile conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine." [PMID:23943861] synonym: "JA-Ile hydrolase" RELATED [] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds created_by: tb creation_date: 2013-10-07T18:37:49Z [Term] id: GO:1990207 name: EmrE multidrug transporter complex namespace: cellular_component def: "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer." [GOC:bhm, PMID:18024586] synonym: "EmrE complex" NARROW [] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1902495 ! transmembrane transporter complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2013-10-08T08:37:52Z [Term] id: GO:1990208 name: positive regulation by symbiont of RNA levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12182338, PMID:18703740] is_a: GO:0052018 ! modulation by symbiont of RNA levels in host created_by: ml creation_date: 2013-10-08T13:31:41Z [Term] id: GO:1990209 name: negative regulation by symbiont of RNA levels in host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18703740] is_a: GO:0052018 ! modulation by symbiont of RNA levels in host created_by: ml creation_date: 2013-10-09T18:09:33Z [Term] id: GO:1990210 name: positive regulation by symbiont of indole acetic acid levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646] synonym: "positive regulation by symbiont of auxin levels in host" EXACT [] synonym: "positive regulation by symbiont of IAA levels in host" EXACT [] is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host created_by: ml creation_date: 2013-10-09T18:54:11Z [Term] id: GO:1990211 name: positive regulation by symbiont of jasmonic acid levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:14617079, PMID:16553894] is_a: GO:0052022 ! modulation by symbiont of jasmonic acid levels in host is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host created_by: ml creation_date: 2013-10-09T18:58:37Z [Term] id: GO:1990212 name: positive regulation by symbiont of ethylene levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:16167902] is_a: GO:0052021 ! modulation by symbiont of ethylene levels in host is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host created_by: ml creation_date: 2013-10-09T19:03:10Z [Term] id: GO:1990213 name: negative regulation by symbiont of salicylic acid levels in host namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:17722699, PMID:20565685] is_a: GO:0052023 ! modulation by symbiont of salicylic acid levels in host is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host created_by: ml creation_date: 2013-10-09T19:06:19Z [Term] id: GO:1990214 name: negative regulation by symbiont of host protein levels namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16840699, PMID:22233353] is_a: GO:0075344 ! modulation by symbiont of host protein levels created_by: ml creation_date: 2013-10-10T15:39:45Z [Term] id: GO:1990215 name: negative regulation by symbiont of host intracellular transport namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0052038 ! modulation by symbiont of host intracellular transport intersection_of: GO:0044068 ! modulation by symbiont of host cellular process intersection_of: negatively_regulates GO:0046907 ! intracellular transport created_by: ml creation_date: 2013-10-10T15:42:22Z [Term] id: GO:1990216 name: positive regulation by symbiont of host transcription namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21994350] is_a: GO:0052026 ! modulation by symbiont of host transcription created_by: ml creation_date: 2013-10-10T15:45:17Z [Term] id: GO:1990217 name: suppression by symbiont of host phytoalexin production namespace: biological_process def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357] synonym: "negative regulation by symbiont of host phytoalexin production" EXACT [] is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production created_by: ml creation_date: 2013-10-10T15:49:33Z [Term] id: GO:1990218 name: positive regulation by symbiont of abscisic acid levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17304219] is_a: GO:0075343 ! modulation by symbiont of abscisic acid levels in host created_by: ml creation_date: 2013-10-10T15:54:10Z [Term] id: GO:1990219 name: positive regulation by symbiont of host protein levels namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20615948] is_a: GO:0075344 ! modulation by symbiont of host protein levels created_by: ml creation_date: 2013-10-10T17:26:03Z [Term] id: GO:1990220 name: GroEL-GroES complex namespace: cellular_component def: "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins." [GOC:bhm, PMID:15313620] synonym: "bacterial chaperonin ATPase complex" RELATED [] synonym: "bacterial chaperonin complex" RELATED [] is_a: GO:0016465 ! chaperonin ATPase complex created_by: bhm creation_date: 2013-10-11T09:20:01Z [Term] id: GO:1990221 name: L-cysteine desulfurase complex namespace: cellular_component def: "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer." [GOC:bhm, PMID:11827487] synonym: "IscS" NARROW [GOC:bhm, GOC:dph] synonym: "NIFS" NARROW [GOC:bhm, GOC:dph] synonym: "NifS" NARROW [GOC:bhm, GOC:dph] synonym: "SufS complex" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-10-11T15:36:34Z [Term] id: GO:1990222 name: ProVWX complex namespace: cellular_component def: "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions." [GOC:bhm, PMID:23249124] synonym: "ATP-binding cassette (ABC) transporter complex ProVWX" EXACT [] is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex created_by: bhm creation_date: 2013-10-16T09:09:17Z [Term] id: GO:1990223 name: positive regulation by symbiont of cytokinin levels in host namespace: biological_process def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24124900] is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host created_by: ml creation_date: 2013-10-16T15:27:27Z [Term] id: GO:1990224 name: NMN phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate." [GOC:rb, PMID:21349851, RHEA:30815] synonym: "beta-nicotinamide D-ribonucleotide phosphatase activity" EXACT [] synonym: "nicotinamide mononucleotide phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity created_by: rb creation_date: 2013-10-21T18:03:41Z [Term] id: GO:1990225 name: rhoptry neck namespace: cellular_component def: "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion." [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020008 ! rhoptry created_by: pr creation_date: 2013-11-03T14:19:26Z [Term] id: GO:1990226 name: histone methyltransferase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527] is_a: GO:0019899 ! enzyme binding created_by: pr creation_date: 2013-11-07T11:59:58Z [Term] id: GO:1990227 name: paranodal junction maintenance namespace: biological_process def: "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [GOC:pr, PMID:24011083] synonym: "axoglial septate junction maintenance" EXACT [] synonym: "paranodal axoglial junction maintenance" EXACT [] synonym: "paranodal septate maintenance" EXACT [] is_a: GO:0045217 ! cell-cell junction maintenance created_by: pr creation_date: 2013-11-07T20:01:46Z [Term] id: GO:1990228 name: sulfurtransferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:17350958] synonym: "SufE complex" NARROW [GOC:bhm] synonym: "SufE dimer" NARROW [GOC:bhm] synonym: "sulfur transfer complex" EXACT [GOC:bhm] synonym: "ThiF-ThiS complex" RELATED [GOC:bhm] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-11-12T09:08:23Z [Term] id: GO:1990229 name: iron-sulfur cluster assembly complex namespace: cellular_component def: "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster." [GOC:bhm, PMID:17350958] synonym: "Fe-S cluster assembly complex" NARROW [GOC:bhm] synonym: "SufBCD complex" NARROW [GOC:bhm] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-11-12T09:15:03Z [Term] id: GO:1990230 name: iron-sulfur cluster transfer complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:19810706] synonym: "Fe-S cluster transfer complex" EXACT [GOC:bhm] synonym: "IscA complex" NARROW [GOC:bhm] synonym: "SufA complex" NARROW [GOC:bhm] synonym: "SufA dimer" NARROW [GOC:bhm] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-11-12T09:17:40Z [Term] id: GO:1990231 name: STING complex namespace: cellular_component def: "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378] synonym: "stimulator of interferon genes complex" EXACT [GOC:bhm, PMID:22705373, PMID:23910378] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030659 ! cytoplasmic vesicle membrane created_by: bhm creation_date: 2013-11-12T10:58:34Z [Term] id: GO:1990232 name: phosphomannomutase complex namespace: cellular_component def: "A protein complex capable of phosphomannomutase activity." [GOC:bhm, PMID:16540464] synonym: "PMM-1 complex" NARROW [GOC:bhm] synonym: "PMM-1 dimer" NARROW [GOC:bhm] synonym: "PMM-2 complex" NARROW [GOC:bhm] synonym: "PMM-2 dimer" NARROW [GOC:bhm] is_a: GO:1990233 ! intramolecular phosphotransferase complex created_by: bhm creation_date: 2013-11-12T13:05:54Z [Term] id: GO:1990233 name: intramolecular phosphotransferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule." [GOC:bhm, PMID:16540464] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-11-12T13:10:12Z [Term] id: GO:1990234 name: transferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] is_a: GO:1902494 ! catalytic complex created_by: bhm creation_date: 2013-11-12T13:20:12Z [Term] id: GO:1990235 name: diamine N-acetyltransferase complex namespace: cellular_component def: "A protein complex which is capable of diamine N-acetyltransferase activity." [GOC:bhm, PMID:8077207] synonym: "SAT complex" NARROW [GOC:bhm] synonym: "SAT tetramer" NARROW [GOC:bhm] synonym: "spermidine acetyltransferase complex" NARROW [GOC:bhm] is_a: GO:1902493 ! acetyltransferase complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2013-11-13T16:29:45Z [Term] id: GO:1990236 name: proteasome core complex import into nucleus namespace: biological_process def: "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus." [GOC:dos, GOC:rb, PMID:23982732] is_a: GO:0006606 ! protein import into nucleus is_a: GO:0031503 ! protein-containing complex localization created_by: rb creation_date: 2013-11-14T23:27:24Z [Term] id: GO:1990237 name: sequestration of proteasome core complex in proteasome storage granule namespace: biological_process def: "Any process where the proteasome core particle (CP) is sequestered in the protein storage granule in the cytoplasm." [GOC:rb, PMID:23982732] is_a: GO:0098545 ! maintenance of protein complex location in cytoplasm relationship: occurs_in GO:0034515 ! proteasome storage granule created_by: rb creation_date: 2013-11-14T23:29:41Z [Term] id: GO:1990238 name: double-stranded DNA endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:PG, PMID:22885404] synonym: "dsDNA-specific endodeoxyribonuclease activity" RELATED [] is_a: GO:0004520 ! endodeoxyribonuclease activity created_by: pg creation_date: 2013-11-15T00:59:42Z [Term] id: GO:1990239 name: steroid hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid hormone." [GOC:ln] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding created_by: pr creation_date: 2013-11-15T09:26:18Z [Term] id: GO:1990241 name: obsolete nucleotide binding complex namespace: cellular_component def: "OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6)." [GOC:bhm, PMID:23910378] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "nucleotide binding complex" EXACT [] is_obsolete: true created_by: bhm creation_date: 2013-11-22T16:22:07Z [Term] id: GO:1990242 name: obsolete innate immune response complex namespace: cellular_component def: "OBSOLETE. A protein complex involved in the innate immune response." [GOC:bhm, PMID:23910378] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "innate immune response complex" EXACT [] is_obsolete: true created_by: bhm creation_date: 2013-11-26T13:36:52Z [Term] id: GO:1990243 name: atf1-pcr1 complex namespace: cellular_component def: "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE)." [PMID:24224056] is_a: GO:0035976 ! transcription factor AP-1 complex created_by: al creation_date: 2013-11-28T11:40:28Z [Term] id: GO:1990244 name: histone kinase activity (H2A-T120 specific) namespace: molecular_function def: "Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A." [PMID:24140421] synonym: "histone threonine kinase activity (H2A-T120 specific)" EXACT [] is_a: GO:0035184 ! histone threonine kinase activity relationship: part_of GO:1990245 ! histone H2A-T120 phosphorylation created_by: sp creation_date: 2013-12-04T06:38:32Z [Term] id: GO:1990245 name: histone H2A-T120 phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone." [PMID:24140421] synonym: "histone H2A phosphorylation at T120" EXACT [] synonym: "histone H2AT120 phosphorylation" EXACT [] is_a: GO:0035405 ! histone-threonine phosphorylation is_a: GO:1990164 ! histone H2A phosphorylation created_by: sp creation_date: 2013-12-04T06:41:30Z [Term] id: GO:1990246 name: uniplex complex namespace: cellular_component def: "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807] synonym: "mitochondrial uniporter complex" EXACT [] synonym: "mitochondrial uniporter holocomplex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex created_by: sp creation_date: 2013-12-04T06:44:35Z [Term] id: GO:1990247 name: N6-methyladenosine-containing RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625] is_a: GO:0003723 ! RNA binding created_by: sp creation_date: 2013-12-04T06:55:29Z [Term] id: GO:1990248 name: regulation of transcription from RNA polymerase II promoter in response to DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress created_by: pg creation_date: 2013-12-04T13:28:04Z [Term] id: GO:1990249 name: nucleotide-excision repair, DNA damage recognition complex namespace: cellular_component def: "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906] is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2013-12-05T16:26:51Z [Term] id: GO:1990250 name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex namespace: cellular_component def: "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906] is_a: GO:1990249 ! nucleotide-excision repair, DNA damage recognition complex created_by: bhm creation_date: 2013-12-05T16:28:45Z [Term] id: GO:1990251 name: Mmi1 nuclear focus namespace: cellular_component def: "A protein complex that forms during vegetative growth and is involved in the selective degradation of meiosis-specific transcripts. Contains at least Mmi1, or an ortholog of it." [GOC:al, GOC:vw, PMID:16823445, PMID:23980030] synonym: "Mmi1 nuclear focus" BROAD [] synonym: "nuclear body" RELATED [] is_a: GO:0016604 ! nuclear body created_by: al creation_date: 2013-12-09T12:07:46Z [Term] id: GO:1990252 name: Syp1 complex namespace: cellular_component def: "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis." [GOC:bhm, PMID:19713939] synonym: "Syp1 dimer" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle created_by: bhm creation_date: 2013-12-09T14:43:00Z [Term] id: GO:1990253 name: cellular response to leucine starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384] xref: CHEBI:25017 is_a: GO:0034198 ! cellular response to amino acid starvation created_by: al creation_date: 2013-12-10T11:55:10Z [Term] id: GO:1990254 name: keratin filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061] is_a: GO:0019215 ! intermediate filament binding created_by: tb creation_date: 2013-12-13T22:05:25Z [Term] id: GO:1990255 name: subsynaptic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:21041451] is_a: GO:0006996 ! organelle organization created_by: tb creation_date: 2013-12-13T23:05:21Z [Term] id: GO:1990256 name: signal clustering namespace: biological_process def: "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response." [GOC:als, PMID:12011072, PMID:15603739] synonym: "ligand clustering" BROAD [GOC:als] is_a: GO:0009966 ! regulation of signal transduction created_by: tb creation_date: 2013-12-18T01:13:59Z [Term] id: GO:1990257 name: piccolo-bassoon transport vesicle namespace: cellular_component def: "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270] synonym: "PTV" RELATED [] is_a: GO:0031410 ! cytoplasmic vesicle created_by: pr creation_date: 2013-12-19T14:12:09Z [Term] id: GO:1990258 name: histone glutamine methylation namespace: biological_process def: "The modification of a histone by addition of a methyl group to an glutamine residue." [PMID:24352239] is_a: GO:0016571 ! histone methylation is_a: GO:0018364 ! peptidyl-glutamine methylation created_by: sp creation_date: 2014-01-02T15:08:02Z [Term] id: GO:1990259 name: histone-glutamine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine." [PMID:24352239] is_a: GO:0036009 ! protein-glutamine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity created_by: sp creation_date: 2014-01-02T15:10:29Z [Term] id: GO:1990260 name: negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling." [PMID:24006488] is_a: GO:0010621 ! negative regulation of transcription by transcription factor localization relationship: part_of GO:0072423 ! response to DNA damage checkpoint signaling created_by: al creation_date: 2014-01-07T17:10:11Z [Term] id: GO:1990261 name: pre-mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259] synonym: "pre-mRNA decay" EXACT [] synonym: "unspliced RNA decay" EXACT [] is_a: GO:0006401 ! RNA catabolic process created_by: rb creation_date: 2014-01-07T23:06:44Z [Term] id: GO:1990262 name: anti-Mullerian hormone signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:hjd, PMID:23624077] comment: An example of this is Amhr2 in M. musculus (Q8K592) a receptor for anti-mullerian hormone, described in PMID:23624077. is_a: GO:0007166 ! cell surface receptor signaling pathway created_by: hjd creation_date: 2014-01-08T20:42:09Z [Term] id: GO:1990263 name: spore wall assembly MAPK cascade namespace: biological_process def: "A MAPK cascade that occurs as a result of deprivation of nourishment." [GOC:al, PMID:7501024] synonym: "MAPK cascade in response to starvation" EXACT [] synonym: "MAPK cascade involved in nutrient response signaling" EXACT [GOC:al] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0051403 ! stress-activated MAPK cascade created_by: al creation_date: 2014-01-09T12:27:52Z [Term] id: GO:1990264 name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity namespace: biological_process def: "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024] is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation relationship: part_of GO:0006469 ! negative regulation of protein kinase activity created_by: al creation_date: 2014-01-09T14:28:41Z [Term] id: GO:1990265 name: platelet-derived growth factor complex namespace: cellular_component def: "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD)." [GOC:bhm, PMID:11331882] comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay). synonym: "PDGF complex" RELATED [] synonym: "PDGF-AA dimer" NARROW [] synonym: "PDGF-AB dimer" NARROW [] synonym: "PDGF-BB dimer" NARROW [] synonym: "PDGF-CC dimer" NARROW [] synonym: "PDGF-DD dimer" NARROW [] xref: IntAct:EBI-2881436 xref: IntAct:EBI-2881443 xref: IntAct:EBI-2881451 is_a: GO:0036454 ! growth factor complex created_by: bhm creation_date: 2014-01-09T16:09:11Z [Term] id: GO:1990266 name: neutrophil migration namespace: biological_process def: "The movement of a neutrophil within or between different tissues and organs of the body." [PMID:1826836] is_a: GO:0097530 ! granulocyte migration created_by: sl creation_date: 2014-01-10T00:17:47Z [Term] id: GO:1990267 name: response to transition metal nanoparticle namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627] synonym: "response to colloidal metal" RELATED [] synonym: "response to neutral metal atoms" RELATED [] is_a: GO:0042221 ! response to chemical created_by: sl creation_date: 2014-01-10T17:16:41Z [Term] id: GO:1990268 name: response to gold nanoparticle namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus." [PMID:23150627] is_a: GO:1990267 ! response to transition metal nanoparticle created_by: sl creation_date: 2014-01-10T17:37:34Z [Term] id: GO:1990269 name: RNA polymerase II C-terminal domain phosphoserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944] synonym: "RNA Pol II C-terminal domain phosphoserine binding" EXACT [GOC:di] synonym: "RNAP II C-terminal domain phosphoserine binding" EXACT [] is_a: GO:0050815 ! phosphoserine residue binding is_a: GO:0099122 ! RNA polymerase II C-terminal domain binding created_by: tb creation_date: 2014-01-11T00:34:59Z [Term] id: GO:1990270 name: platelet-derived growth factor receptor-ligand complex namespace: cellular_component def: "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, PMID:11331882] comment: An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay). synonym: "PDGF complex" BROAD [] synonym: "PDGF receptor-ligand complex" EXACT [] synonym: "PDGF-AA-receptor alpha complex" NARROW [] synonym: "PDGF-AB-receptor alpha complex" NARROW [] synonym: "PDGF-AB-receptor beta complex" NARROW [] synonym: "PDGF-BB-receptor alpha complex" NARROW [] synonym: "PDGF-BB-receptor alpha-beta complex" NARROW [] synonym: "PDGF-BB-receptor beta complex" NARROW [] synonym: "PDGF-CC-receptor alpha complex" NARROW [] synonym: "PDGF-CC-receptor alpha-beta complex" NARROW [] synonym: "PDGF-CC-receptor beta complex" NARROW [] synonym: "PDGF-DD-receptor alpha-beta complex" NARROW [] synonym: "PDGF-DD-receptor beta complex" NARROW [] synonym: "receptor-ligand complex" BROAD [] xref: IntAct:EBI-9080360 is_a: GO:0098797 ! plasma membrane protein complex relationship: has_part GO:0043235 ! receptor complex relationship: has_part GO:1990265 ! platelet-derived growth factor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2014-01-14T11:12:22Z [Term] id: GO:1990271 name: obsolete anti-Mullerian hormone namespace: molecular_function def: "OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077] comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077. synonym: "anti-Mullerian hormone" EXACT [] is_obsolete: true created_by: hjd creation_date: 2014-01-14T20:38:39Z [Term] id: GO:1990272 name: anti-Mullerian hormone receptor activity namespace: molecular_function def: "Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077] comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077. is_a: GO:0016500 ! protein-hormone receptor activity relationship: part_of GO:1990262 ! anti-Mullerian hormone signaling pathway created_by: hjd creation_date: 2014-01-14T21:41:35Z [Term] id: GO:1990273 name: snRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an snRNA molecule." [PMID:22740346] is_a: GO:0016180 ! snRNA processing is_a: GO:0034471 ! ncRNA 5'-end processing created_by: al creation_date: 2014-01-15T15:32:06Z [Term] id: GO:1990274 name: mitotic actomyosin contractile ring disassembly namespace: biological_process def: "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673] synonym: "mitotic actomyosin ring disassembly" RELATED [] synonym: "mitotic CAR disassembly" EXACT [] synonym: "mitotic constriction ring disassembly" RELATED [] synonym: "mitotic contractile actomyosin ring disassembly" EXACT [] synonym: "mitotic cytokinetic ring disassembly" RELATED [] is_a: GO:1902410 ! mitotic cytokinetic process is_a: GO:1902621 ! actomyosin contractile ring disassembly intersection_of: GO:1902621 ! actomyosin contractile ring disassembly intersection_of: part_of GO:0000281 ! mitotic cytokinesis created_by: mah creation_date: 2014-01-16T10:25:42Z [Term] id: GO:1990275 name: preribosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a preribosome." [GOC:di, PMID:22735702] is_a: GO:0043021 ! ribonucleoprotein complex binding created_by: tb creation_date: 2014-01-16T19:14:50Z [Term] id: GO:1990276 name: RNA 5'-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule." [GOC:al, GOC:vw, PMID:22740346] is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: pr creation_date: 2014-01-28T09:44:16Z [Term] id: GO:1990277 name: parasexual conjugation with cellular fusion namespace: biological_process def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types, without the formation of zygotes. An example of this process is found in Candida albicans." [GOC:di] synonym: "mating" BROAD [] is_a: GO:0000746 ! conjugation is_a: GO:0140253 ! cell-cell fusion created_by: pr creation_date: 2014-01-28T10:30:20Z [Term] id: GO:1990278 name: obsolete positive regulation of MBF transcription factor activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF." [PMID:11795845] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "positive regulation of MBF transcription factor activity" EXACT [] is_obsolete: true created_by: al creation_date: 2014-01-29T14:43:44Z [Term] id: GO:1990279 name: obsolete negative regulation of MBF transcription factor activity namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF." [PMID:24006488] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "negative regulation of MBF transcription factor activity" EXACT [] is_obsolete: true created_by: al creation_date: 2014-01-29T14:46:52Z [Term] id: GO:1990280 name: RNA localization to chromatin namespace: biological_process def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] synonym: "RNA localisation to chromatin" EXACT [] is_a: GO:0006403 ! RNA localization created_by: mah creation_date: 2014-01-30T15:55:34Z [Term] id: GO:1990281 name: efflux pump complex namespace: cellular_component def: "A protein complex that is capable of efflux transmembrane transporter activity." [GOC:dos, PMID:21556065, PMID:9417051] synonym: "efflux pump" EXACT [] synonym: "efflux transmembrane transporter complex" EXACT [] is_a: GO:1902495 ! transmembrane transporter complex created_by: tt creation_date: 2014-01-31T08:19:53Z [Term] id: GO:1990294 name: peptidyl-threonine trans-autophosphorylation namespace: biological_process def: "The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [PMID:19357077] is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:0036290 ! protein trans-autophosphorylation created_by: al creation_date: 2014-02-05T12:42:46Z [Term] id: GO:1990295 name: post-anaphase microtubule array namespace: cellular_component def: "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091] comment: The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical. synonym: "PAA" EXACT [] synonym: "post-anaphase array" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0000923 ! equatorial microtubule organizing center relationship: part_of GO:0015630 ! microtubule cytoskeleton created_by: mah creation_date: 2014-02-20T13:54:23Z [Term] id: GO:1990297 name: renal amino acid absorption namespace: biological_process def: "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:hjd, PMID:1526373] is_a: GO:0070293 ! renal absorption created_by: hjd creation_date: 2014-02-25T22:05:57Z [Term] id: GO:1990298 name: bub1-bub3 complex namespace: cellular_component def: "Protein complex that associates with the kinetochores." [PMID:22521786] is_a: GO:0032991 ! protein-containing complex created_by: al creation_date: 2014-02-26T09:23:04Z [Term] id: GO:1990299 name: Bub1-Bub3 complex localization to kinetochore namespace: biological_process def: "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore." [PMID:22521786] is_a: GO:0034501 ! protein localization to kinetochore is_a: GO:0034629 ! cellular protein-containing complex localization created_by: al creation_date: 2014-02-26T09:29:13Z [Term] id: GO:1990300 name: cellulosome binding namespace: molecular_function alt_id: GO:1990301 def: "Interacting selectively and non-covalently with the cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides." [GOC:mengo_curators, PMID:11893054, PMID:15197390] synonym: "scaffoldin complex binding" NARROW [] is_a: GO:0005488 ! binding creation_date: 2014-02-26T22:41:22Z [Term] id: GO:1990302 name: Bre1-Rad6 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, PMID:19531475] comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). synonym: "Bre1-Rad6 complex" EXACT [] xref: IntAct:EBI-9102228 is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-02-28T16:50:34Z [Term] id: GO:1990303 name: UBR1-RAD6 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." [GOC:bhm, PMID:19531475] comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). synonym: "UBR1-RAD6 complex" EXACT [] xref: IntAct:EBI-9103673 is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-03-03T21:43:49Z [Term] id: GO:1990304 name: MUB1-RAD6-UBR2 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme." [GOC:bhm, PMID:18070918] comment: This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918. xref: IntAct:EBI-9117531 is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-03-03T21:54:21Z [Term] id: GO:1990305 name: RAD6-UBR2 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation." [GOC:bhm, PMID:15504724] comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:15504724 synonym: "RAD6-UBR2 complex" EXACT [] xref: IntAct:EBI-9116509 is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-03-03T22:14:32Z [Term] id: GO:1990306 name: RSP5-BUL ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, PMID:9931424] comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424 synonym: "RSP5-BUL1 complex" EXACT [] synonym: "RSP5-BUL2 complex" RELATED [] xref: IntAct:EBI-9105217 xref: IntAct:EBI-9105295 is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-03-03T22:53:01Z [Term] id: GO:1990308 name: type-I dockerin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T03:10:37Z [Term] id: GO:1990309 name: type-II dockerin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T03:16:49Z [Term] id: GO:1990310 name: type-III dockerin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T03:22:36Z [Term] id: GO:1990311 name: type-I cohesin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T04:47:31Z [Term] id: GO:1990312 name: type-II cohesin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T04:51:07Z [Term] id: GO:1990313 name: type-III cohesin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] is_a: GO:0019904 ! protein domain specific binding created_by: tt creation_date: 2014-03-07T04:58:07Z [Term] id: GO:1990314 name: cellular response to insulin-like growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:20042609] synonym: "cellular response to insulin-like growth factor" EXACT [] is_a: GO:0071375 ! cellular response to peptide hormone stimulus created_by: sl creation_date: 2014-03-07T19:38:21Z [Term] id: GO:1990315 name: Mcs4 RR-MAPKKK complex namespace: cellular_component def: "A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress." [PMID:24255738] comment: In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1. is_a: GO:0032991 ! protein-containing complex created_by: al creation_date: 2014-03-14T09:59:45Z [Term] id: GO:1990316 name: Atg1/ULK1 kinase complex namespace: cellular_component alt_id: GO:0034273 alt_id: GO:0070969 def: "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598] synonym: "ATG1 kinase complex" EXACT [] synonym: "ATG1-ATG13 complex" EXACT [] synonym: "ATG1/ULK1 signaling complex" EXACT [] synonym: "Atg1p signalling complex" EXACT [] synonym: "autophagy-initiation complex" EXACT [GOC:autophagy, GOC:pad, GOC:PARL, PMID:26754330] synonym: "ULK complex" EXACT [PMID:28816597] synonym: "ULK1 complex" EXACT [PMID:26921696] synonym: "ULK1 signaling complex" EXACT [] synonym: "ULK1-ATG13-FIP200 complex" EXACT [] synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [] xref: IntAct:EBI-2352849 is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0005737 ! cytoplasm created_by: bhm creation_date: 2014-03-14T10:55:11Z [Term] id: GO:1990317 name: Gin4 complex namespace: cellular_component def: "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved." [GOC:bhm, PMID:12058072] synonym: "Gin4-septin complex" EXACT [] xref: IntAct:EBI-2431392 is_a: GO:1902554 ! serine/threonine protein kinase complex relationship: part_of GO:0000144 ! cellular bud neck septin ring created_by: bhm creation_date: 2014-03-14T12:07:05Z [Term] id: GO:1990318 name: collagen type XIX trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529092 is_a: GO:0005593 ! FACIT collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer created_by: bhm creation_date: 2014-03-14T16:05:57Z [Term] id: GO:1990319 name: collagen type XX trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XX) chains." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529132 is_a: GO:0005593 ! FACIT collagen trimer created_by: bhm creation_date: 2014-03-14T16:31:21Z [Term] id: GO:1990320 name: collagen type XXI trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529143 is_a: GO:0005593 ! FACIT collagen trimer created_by: bhm creation_date: 2014-03-14T16:40:14Z [Term] id: GO:1990321 name: collagen type XXII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529189 is_a: GO:0005593 ! FACIT collagen trimer created_by: bhm creation_date: 2014-03-14T16:50:05Z [Term] id: GO:1990322 name: collagen type XXIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529234 is_a: GO:0030936 ! transmembrane collagen trimer created_by: bhm creation_date: 2014-03-14T22:01:00Z [Term] id: GO:1990323 name: collagen type XXIV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529258 is_a: GO:0005583 ! fibrillar collagen trimer created_by: bhm creation_date: 2014-03-14T22:05:53Z [Term] id: GO:1990324 name: collagen type XXVI trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXVI) chains." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529362 is_a: GO:0005581 ! collagen trimer relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: bhm creation_date: 2014-03-16T23:02:35Z [Term] id: GO:1990325 name: collagen type XXVII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." [GOC:bhm, PMID:17876790, PMID:21421911] xref: IntAct:EBI-2529377 is_a: GO:0005583 ! fibrillar collagen trimer created_by: bhm creation_date: 2014-03-16T23:13:15Z [Term] id: GO:1990326 name: collagen type XXVIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXVIII) chains." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529426 is_a: GO:0005581 ! collagen trimer relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: bhm creation_date: 2014-03-16T23:15:28Z [Term] id: GO:1990327 name: collagen type XXV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790] xref: IntAct:EBI-2529312 is_a: GO:0030936 ! transmembrane collagen trimer created_by: bhm creation_date: 2014-03-17T09:28:50Z [Term] id: GO:1990328 name: RPB4-RPB7 complex namespace: cellular_component def: "A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways." [GOC:bhm, PMID:15591044] comment: Fixed term label, definition and subclass as requested https://github.com/geneontology/go-ontology/issues/10931 synonym: "RNA polymerase II, RPB4-RPB7 subcomplex" NARROW [] xref: IntAct:EBI-2945755 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005622 ! intracellular created_by: bhm creation_date: 2014-03-17T09:37:07Z [Term] id: GO:1990329 name: IscS-TusA complex namespace: cellular_component def: "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups." [GOC:bhm, PMID:20404999] xref: IntAct:EBI-8869931 is_a: GO:1990221 ! L-cysteine desulfurase complex is_a: GO:1990228 ! sulfurtransferase complex created_by: bhm creation_date: 2014-03-17T10:00:47Z [Term] id: GO:1990330 name: IscS-IscU complex namespace: cellular_component def: "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group." [GOC:bhm, PMID:20404999] xref: IntAct:EBI-8870238 is_a: GO:1990221 ! L-cysteine desulfurase complex is_a: GO:1990228 ! sulfurtransferase complex created_by: bhm creation_date: 2014-03-17T10:08:19Z [Term] id: GO:1990331 name: Hpa2 acetyltransferase complex namespace: cellular_component def: "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules." [GOC:bhm, PMID:10600387] xref: IntAct:EBI-8871758 is_a: GO:0070775 ! H3 histone acetyltransferase complex is_a: GO:1902562 ! H4 histone acetyltransferase complex created_by: bhm creation_date: 2014-03-17T10:18:23Z [Term] id: GO:1990332 name: Ire1 complex namespace: cellular_component def: "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript." [GOC:bf, GOC:bhm, PMID:18191223, PMID:25437541] comment: An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay). synonym: "ERN1 complex" RELATED [HGNC:3449] synonym: "IRE1 dimer" EXACT [PMID:25437541] xref: IntAct:EBI-8872439 is_a: GO:0098796 ! membrane protein complex is_a: GO:1902554 ! serine/threonine protein kinase complex is_a: GO:1902555 ! endoribonuclease complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: bhm creation_date: 2014-03-17T10:46:58Z [Term] id: GO:1990333 name: mitotic checkpoint complex, CDC20-MAD2 subcomplex namespace: cellular_component def: "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20." [GOC:bhm, PMID:15879521] comment: An example of this is cdc20 in Saccharomyces cerevisiae (P26309) in PMID:15879521 (inferred from direct assay). synonym: "CDC20-MAD2 complex" EXACT [] xref: IntAct:EBI-1270646 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0033597 ! mitotic checkpoint complex created_by: bhm creation_date: 2014-03-17T14:11:35Z [Term] id: GO:1990334 name: Bfa1-Bub2 complex namespace: cellular_component def: "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, PMID:16449187] xref: IntAct:EBI-1271344 is_a: GO:1902773 ! GTPase activator complex relationship: part_of GO:0005816 ! spindle pole body created_by: bhm creation_date: 2014-03-17T14:34:21Z [Term] id: GO:1990335 name: process resulting in tolerance to alcohol namespace: biological_process def: "A response to alcohol that results in a state of tolerance to alcohol." [GOC:mengo_curators, PMID:24014527] is_a: GO:0097305 ! response to alcohol created_by: tt creation_date: 2014-03-20T11:02:26Z [Term] id: GO:1990336 name: process resulting in tolerance to butan-1-ol namespace: biological_process def: "A response to butan-1-ol that results in a state of tolerance to butan-1-ol." [GOC:mengo_curators, PMID:24014527] is_a: GO:1901422 ! response to butan-1-ol created_by: tt creation_date: 2014-03-20T11:07:00Z [Term] id: GO:1990337 name: process resulting in tolerance to isobutanol namespace: biological_process def: "A response to isobutanol that results in a state of tolerance to isobutanol." [GOC:mengo_curators, PMID:24014527] is_a: GO:1902665 ! response to isobutanol created_by: tt creation_date: 2014-03-20T11:10:04Z [Term] id: GO:1990338 name: laminin-14 complex namespace: cellular_component def: "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709] synonym: "laminin-423" EXACT [GOC:dph, GOC:sl, PMID:15979864] xref: IntAct:EBI-2530020 is_a: GO:0043256 ! laminin complex created_by: bhm creation_date: 2014-03-20T23:37:11Z [Term] id: GO:1990339 name: laminin-522 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709] synonym: "laminin-522" EXACT [] xref: IntAct:EBI-2530034 is_a: GO:0043256 ! laminin complex created_by: bhm creation_date: 2014-03-20T23:41:32Z [Term] id: GO:1990340 name: laminin-15 complex namespace: cellular_component def: "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains." [GOC:bhm, PMID:17453709] synonym: "laminin-523" EXACT [] xref: IntAct:EBI-2530049 is_a: GO:0043256 ! laminin complex created_by: bhm creation_date: 2014-03-20T23:48:25Z [Term] id: GO:1990341 name: thrombospondin complex namespace: cellular_component def: "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour." [GOC:bhm, PMID:18193164] xref: IntAct:EBI-2530370 xref: IntAct:EBI-2530917 xref: IntAct:EBI-2530961 xref: IntAct:EBI-2530975 xref: IntAct:EBI-2531058 xref: IntAct:EBI-9251379 xref: IntAct:EBI-9251408 xref: IntAct:EBI-9251455 xref: IntAct:EBI-9251502 xref: IntAct:EBI-9251524 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0031012 ! extracellular matrix created_by: bhm creation_date: 2014-03-21T14:27:07Z [Term] id: GO:1990342 name: heterochromatin island namespace: cellular_component def: "A region of heterochromatin that is formed dynamically in response to environmental signals by a process that does not require RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:22144463, PMID:24210919] comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth. is_a: GO:0005720 ! nuclear heterochromatin created_by: mah creation_date: 2014-03-21T15:26:44Z [Term] id: GO:1990343 name: heterochromatin domain namespace: cellular_component def: "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919] comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons. synonym: "HOOD" EXACT [PMID:23151475] is_a: GO:0005720 ! nuclear heterochromatin created_by: mah creation_date: 2014-03-21T15:40:48Z [Term] id: GO:1990344 name: secondary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0140278 ! mitotic division septum assembly created_by: mah creation_date: 2014-03-24T13:24:48Z [Term] id: GO:1990345 name: MTREC complex namespace: cellular_component def: "A protein complex that consists of a heterodimer formed by Red1 and Mtl1 or homologs thereof, and that promotes degradation of mRNAs and noncoding RNAs and associates with different proteins to assemble heterochromatin via distinct mechanisms." [PMID:24210919] comment: An example of this is the complex formed by Red1 and Mtl1 in S. pombe (UniProt symbols Q9UTR8 and O13799 respectively) in PMID:24210919 (inferred from direct assay). synonym: "Mtl1-Red1 core complex" EXACT [PMID:24210919] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: mah creation_date: 2014-03-24T13:30:52Z [Term] id: GO:1990346 name: BID-BCL-xl complex namespace: cellular_component def: "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, PMID:14634621] xref: IntAct:EBI-709568 xref: IntAct:EBI-822507 xref: IntAct:EBI-822526 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-03-25T00:18:41Z [Term] id: GO:1990347 name: obsolete G*/A mismatch-specific adenine-DNA glycosylase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site." [PMID:24559510] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "G*/A mismatch-specific adenine-DNA glycosylase activity" EXACT [] is_obsolete: true created_by: al creation_date: 2014-03-25T10:14:37Z [Term] id: GO:1990348 name: obsolete G/A mismatch specific adenine DNA glycosylase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me." [PMID:9737967] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "G/A mismatch specific adenine DNA glycosylase activity" EXACT [] is_obsolete: true created_by: al creation_date: 2014-03-25T10:55:45Z [Term] id: GO:1990349 name: gap junction-mediated intercellular transport namespace: biological_process def: "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells." [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction] is_a: GO:0010496 ! intercellular transport created_by: hjd creation_date: 2014-03-25T18:05:44Z [Term] id: GO:1990350 name: glucose transporter complex namespace: cellular_component def: "A protein complex facilitating glucose transport into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). xref: IntAct:EBI-959455 xref: IntAct:EBI-960644 xref: IntAct:EBI-960674 is_a: GO:1990351 ! transporter complex created_by: bhm creation_date: 2014-03-26T14:12:05Z [Term] id: GO:1990351 name: transporter complex namespace: cellular_component def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-03-26T14:23:27Z [Term] id: GO:1990352 name: BRE1 E3 ubiquitin ligase complex namespace: cellular_component def: "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes." [GOC:bhm, PMID:19531475] comment: An example of this is BRE1 in Saccharomyces cerevisiae (UniProt symbol Q07457) in PMID:19531475 (inferred from direct assay). synonym: "BRE1 E3 ubiquitin-protein ligase complex" EXACT [] synonym: "BRE1 oligomer" EXACT [] xref: IntAct:EBI-9102292 is_a: GO:0000151 ! ubiquitin ligase complex created_by: bhm creation_date: 2014-03-27T13:49:05Z [Term] id: GO:1990353 name: Fused-Smurf ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation." [GOC:bhm, PMID:21145463] comment: An example of this is FUSED in Drosophila melanogaster (UniProt symbol P23647) in PMID:21145463 (inferred from direct assay). xref: IntAct:EBI-3405462 is_a: GO:0000151 ! ubiquitin ligase complex created_by: bhm creation_date: 2014-03-27T14:02:09Z [Term] id: GO:1990354 name: activated SUMO-E1 ligase complex namespace: cellular_component def: "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins." [GOC:bhm, PMID:15660128] comment: An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay). synonym: "SUMO-SAE1/2 complex" NARROW [] xref: IntAct:EBI-9345927 is_a: GO:0106068 ! SUMO ligase complex relationship: has_part GO:0031510 ! SUMO activating enzyme complex relationship: part_of GO:0005634 ! nucleus created_by: bhm creation_date: 2014-03-31T13:22:45Z [Term] id: GO:1990355 name: L-methionine salvage from methionine sulphoxide namespace: biological_process def: "The generation of L-methionine from methionine sulphoxide." [PMID:24118096] synonym: "methionine salvage from methionine sulphoxide" BROAD [] is_a: GO:0071267 ! L-methionine salvage created_by: al creation_date: 2014-04-02T12:55:01Z [Term] id: GO:1990356 name: sumoylated E2 ligase complex namespace: cellular_component def: "A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase." [GOC:bhm, PMID:18691969] comment: An example of this is UBC9 in human (UniProt symbol P63279) in PMID:18691969 (inferred from direct assay). xref: IntAct:EBI-9347978 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-04-02T14:06:56Z [Term] id: GO:1990357 name: terminal web namespace: cellular_component def: "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells." [GOC:kmv, http://en.wikipedia.org/wiki/Terminal_web, PMID:19437512, PMID:24677443, PMID:7511618] is_a: GO:0030864 ! cortical actin cytoskeleton created_by: pr creation_date: 2014-04-03T14:29:59Z [Term] id: GO:1990358 name: xylanosome namespace: cellular_component def: "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose." [GOC:mengo_curators, PMID:16769147] synonym: "xylanolytic complex" EXACT [] is_a: GO:1902494 ! catalytic complex created_by: tt creation_date: 2014-04-05T18:08:54Z [Term] id: GO:1990359 name: stress response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus." [GOC:kmv, pmid:17888400] synonym: "response to zinc ion stress" EXACT [] synonym: "response to zinc toxicity" RELATED [] synonym: "stress response to zinc" BROAD [] is_a: GO:0010043 ! response to zinc ion is_a: GO:0097501 ! stress response to metal ion created_by: kmv creation_date: 2014-04-14T15:54:05Z [Term] id: GO:1990360 name: PKM2 protein kinase complex namespace: cellular_component def: "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer." [GOC:bhm, PMID:24606918] synonym: "PKM2-SAICAR complex" RELATED [] synonym: "PKM2-SAICAR protein kinase complex" RELATED [] is_a: GO:1902911 ! protein kinase complex created_by: bhm creation_date: 2014-04-17T14:03:36Z [Term] id: GO:1990361 name: PKM2 pyruvate kinase complex namespace: cellular_component def: "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013)." [GOC:bhm, PMID:24606918] comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). synonym: "PKM2 homotetramer" EXACT [] is_a: GO:1902912 ! pyruvate kinase complex created_by: bhm creation_date: 2014-04-17T14:16:24Z [Term] id: GO:1990362 name: butanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+." [GOC:mengo_curators, PMID:1999395] xref: PMID:1999395 xref: RHEA:33200 is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity created_by: tt creation_date: 2014-04-23T21:14:09Z [Term] id: GO:1990363 name: obsolete response to hydrolysate namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis)." [GOC:mengo_curators, PMID:23356676] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to hydrolysate" EXACT [] xref: PMID:23356676 is_obsolete: true created_by: tt creation_date: 2014-04-23T22:12:24Z [Term] id: GO:1990364 name: obsolete response to aldehyde namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde." [GOC:mengo_curators, PMID:23356676] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to aldehyde" EXACT [] xref: PMID:23356676 is_obsolete: true created_by: tt creation_date: 2014-04-23T22:18:04Z [Term] id: GO:1990365 name: obsolete response to phenol namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols." [GOC:mengo_curators, PMID:23356676] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to phenol" EXACT [] xref: PMID:23356676 is_obsolete: true created_by: tt creation_date: 2014-04-23T22:20:00Z [Term] id: GO:1990366 name: obsolete response to organic acid namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid." [GOC:mengo_curators, PMID:23356676] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to organic acid" EXACT [] xref: PMID:23356676 is_obsolete: true created_by: tt creation_date: 2014-04-23T22:21:26Z [Term] id: GO:1990367 name: process resulting in tolerance to organic substance namespace: biological_process def: "A response that results in a state of tolerance to an organic substance." [GOC:mengo_curators, PMID:23356676] xref: PMID:23356676 is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-04-23T22:25:05Z [Term] id: GO:1990368 name: obsolete process resulting in tolerance to hydrolysate namespace: biological_process def: "OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis)." [GOC:mengo_curators, PMID:23356676] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "process resulting in tolerance to hydrolysate" EXACT [] xref: PMID:23356676 is_obsolete: true created_by: tt creation_date: 2014-04-23T22:27:51Z [Term] id: GO:1990369 name: process resulting in tolerance to ketone namespace: biological_process def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] xref: PMID:23356676 is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-04-23T22:29:41Z [Term] id: GO:1990370 name: process resulting in tolerance to aldehyde namespace: biological_process def: "A response that results in a state of tolerance to aldehyde." [GOC:mengo_curators, PMID:23356676] xref: PMID:23356676 is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-04-23T22:30:50Z [Term] id: GO:1990371 name: process resulting in tolerance to phenol namespace: biological_process def: "A response that results in a state of tolerance to phenol." [GOC:mengo_curators, PMID:23356676] xref: PMID:23356676 is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-04-23T22:32:48Z [Term] id: GO:1990372 name: process resulting in tolerance to organic acid namespace: biological_process def: "A response that results in a state of tolerance to organic acid." [GOC:mengo_curators, PMID:23356676] xref: PMID:23356676 is_a: GO:0010033 ! response to organic substance created_by: tt creation_date: 2014-04-23T22:34:12Z [Term] id: GO:1990373 name: process resulting in tolerance to alkane namespace: biological_process def: "A response that results in a state of tolerance to alkane." [GOC:mengo_curators, PMID:23826995] xref: PMID:23826995 is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-04-24T00:28:50Z [Term] id: GO:1990374 name: Kir2 inward rectifier potassium channel complex namespace: cellular_component def: "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells." [GOC:bhm, PMID:16834334] comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). synonym: "Kir2.1 complex" NARROW [] xref: IntAct:EBI-9510554 xref: IntAct:EBI-9511072 is_a: GO:1902937 ! inward rectifier potassium channel complex created_by: bhm creation_date: 2014-04-25T15:29:15Z [Term] id: GO:1990375 name: baculum development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296] synonym: "os penis development" EXACT [GOC:sl] synonym: "penile bone development" EXACT [GOC:sl] synonym: "penis bone development" EXACT [GOC:sl] is_a: GO:0048608 ! reproductive structure development is_a: GO:0060348 ! bone development created_by: sl creation_date: 2014-05-01T23:59:13Z [Term] id: GO:1990376 name: obsolete negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition." [PMID:9135083] comment: This term was made obsolete because it would not be used for annotation. is_obsolete: true created_by: al creation_date: 2014-05-07T08:51:19Z [Term] id: GO:1990377 name: organomineral extracellular matrix namespace: cellular_component def: "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight." [GOC:jh2, PMID:15994301] comment: An example is found in shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis (PMID:15994301), but the term may also be useful to annotate bone and eggshell proteins. is_a: GO:0031012 ! extracellular matrix created_by: pr creation_date: 2014-05-07T10:02:28Z [Term] id: GO:1990378 name: upstream stimulatory factor complex namespace: cellular_component def: "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters." [GOC:bhm, PMID:8576131] comment: An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay). synonym: "USF complex" EXACT [] synonym: "USF1 homodimer" NARROW [] synonym: "USF1-USF2 heterodimer" NARROW [] synonym: "USF2 homodimer" NARROW [] xref: IntAct:EBI-9518693 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2014-05-07T15:41:42Z [Term] id: GO:1990379 name: lipid transport across blood-brain barrier namespace: biological_process def: "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162] synonym: "lipid transport across blood brain barrier" EXACT [] is_a: GO:0006869 ! lipid transport is_a: GO:0150104 ! transport across blood-brain barrier created_by: sjp creation_date: 2014-05-08T09:52:28Z [Term] id: GO:1990380 name: Lys48-specific deubiquitinase activity namespace: molecular_function def: "Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:bf, GOC:PARL, PMID:22970133] synonym: "K48-specific deubiquitinase activity" EXACT [PMID:22970133] synonym: "K48-specific deubiquitinating activity" EXACT [PMID:22970133] xref: Reactome:R-HSA-5690870 "OTUD7B,TNFAIP3 deubiquitinate TRAF6" is_a: GO:0101005 ! ubiquitinyl hydrolase activity relationship: part_of GO:0071108 ! protein K48-linked deubiquitination created_by: bf creation_date: 2014-05-15T14:31:07Z [Term] id: GO:1990381 name: ubiquitin-specific protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750] synonym: "deubiquitinase binding" EXACT [GOC:bf] synonym: "deubiquitinating enzyme binding" EXACT [PMID:24063750] is_a: GO:0002020 ! protease binding created_by: bf creation_date: 2014-05-19T10:01:53Z [Term] id: GO:1990382 name: obsolete melanosome assembly namespace: biological_process def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:bf, GOC:PARL, PMID:22511774] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "melanosome biogenesis" EXACT [PMID:22511774] is_obsolete: true created_by: bf creation_date: 2014-05-20T16:06:04Z [Term] id: GO:1990383 name: cellular response to biotin starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin." [PMID:12557275] is_a: GO:0009267 ! cellular response to starvation created_by: al creation_date: 2014-05-21T10:06:58Z [Term] id: GO:1990384 name: hyaloid vascular plexus regression namespace: biological_process def: "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression." [GOC:hjd, PMID:18841878] is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0043010 ! camera-type eye development created_by: hjd creation_date: 2014-05-28T18:43:21Z [Term] id: GO:1990385 name: meiotic spindle midzone namespace: cellular_component def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv\,PMID\:12707312] is_a: GO:0051233 ! spindle midzone relationship: part_of GO:0072687 ! meiotic spindle created_by: kmv creation_date: 2014-05-29T20:52:44Z [Term] id: GO:1990386 name: mitotic cleavage furrow ingression namespace: biological_process def: "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [GOC:kmv, PMID:12707312] is_a: GO:0036090 ! cleavage furrow ingression is_a: GO:1902410 ! mitotic cytokinetic process created_by: kmv creation_date: 2014-05-29T20:58:27Z [Term] id: GO:1990387 name: isogloboside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides)." [GOC:hjd, PMID:22875802] xref: CHEBI:78257 is_a: GO:0006688 ! glycosphingolipid biosynthetic process created_by: hjd creation_date: 2014-05-30T17:36:51Z [Term] id: GO:1990388 name: xylem-to-phloem iron transport namespace: biological_process def: "The directed movement of iron ions into the phloem from the xylem." [GOC:tb, PMID:24867923] is_a: GO:0006826 ! iron ion transport is_a: GO:0010233 ! phloem transport created_by: tb creation_date: 2014-05-30T21:06:50Z [Term] id: GO:1990389 name: CUE1-UBC7 ubiquitin-conjugating enzyme complex namespace: cellular_component def: "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1." [GOC:bhm, PMID:23028185] comment: An example of this is UBC7 in Saccharomyces cerevisiae (Q02159) in PMID:16179953 (inferred from direct assay). synonym: "CUE1-UBC7 ubiquitin-conjugating enzyme (E2)" EXACT [] xref: IntAct:EBI-9207004 is_a: GO:0000835 ! ER ubiquitin ligase complex is_a: GO:0031371 ! ubiquitin conjugating enzyme complex created_by: bhm creation_date: 2014-06-02T15:35:58Z [Term] id: GO:1990390 name: protein K33-linked ubiquitination namespace: biological_process def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein." [PMID:24768539] is_a: GO:0000209 ! protein polyubiquitination created_by: sp creation_date: 2014-06-03T12:22:05Z [Term] id: GO:1990391 name: DNA repair complex namespace: cellular_component def: "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] synonym: "DNA damage repair complex" EXACT [] synonym: "WHY1 complex" NARROW [] xref: IntAct:EBI-16426962 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2014-06-04T09:15:24Z [Term] id: GO:1990392 name: EFF-1 complex namespace: cellular_component def: "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer." [GOC:bhm, PMID:24725407] comment: An example of this is eff-1 in C. elegans (G5ECA1) in PMID:24725407 (inferred from direct assay). xref: IntAct:EBI-9526622 is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2014-06-04T14:45:02Z [Term] id: GO:1990393 name: 3M complex namespace: cellular_component def: "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity." [PMID:24793695, PMID:24793696] is_a: GO:0032991 ! protein-containing complex created_by: sp creation_date: 2014-06-05T06:40:49Z [Term] id: GO:1990394 name: cellular response to cell wall damage namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell." [PMID:17287531] is_a: GO:0051716 ! cellular response to stimulus relationship: has_part GO:0071433 ! cell wall repair created_by: al creation_date: 2014-06-05T16:45:33Z [Term] id: GO:1990395 name: meiotic spindle pole body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw] is_a: GO:0051300 ! spindle pole body organization is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0000212 ! meiotic spindle organization created_by: tb creation_date: 2014-06-06T01:41:05Z [Term] id: GO:1990396 name: single-strand break repair via homologous recombination namespace: biological_process def: "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:bhm, PMID:24339919] is_a: GO:0000012 ! single strand break repair is_a: GO:0000725 ! recombinational repair is_a: GO:0042275 ! error-free postreplication DNA repair created_by: bhm creation_date: 2014-06-09T10:47:04Z [Term] id: GO:1990397 name: queuosine salvage namespace: biological_process def: "Any process which produces queuosine from derivatives of it, without de novo synthesis." [GOC:vw, PMID:24911101] is_a: GO:0008616 ! queuosine biosynthetic process is_a: GO:0043174 ! nucleoside salvage created_by: pr creation_date: 2014-06-10T14:56:12Z [Term] id: GO:1990398 name: Cus cation efflux complex namespace: cellular_component def: "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth." [GOC:bhm, PMID:23122209] comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209. synonym: "copper efflux complex" NARROW [] synonym: "copper efflux system" NARROW [] synonym: "Cus cation efflux system" EXACT [] synonym: "silver efflux complex" NARROW [] synonym: "silver efflux system" NARROW [] xref: IntAct:EBI-9010676 is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1903113 ! copper ion transmembrane transporter complex is_a: GO:1903114 ! silver ion transmembrane transporter complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2014-06-11T08:51:48Z [Term] id: GO:1990399 name: epithelium regeneration namespace: biological_process def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688] synonym: "regeneration of epithelium" EXACT [] is_a: GO:0042246 ! tissue regeneration is_a: GO:0060429 ! epithelium development created_by: sl creation_date: 2014-06-12T17:14:42Z [Term] id: GO:1990400 name: mitochondrial ribosomal large subunit rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mitochondrial large ribosomal subunit RNA (LSU rRNA), a constituent of the mitochondrial large ribosomal subunit." [PMID:24206665] comment: In S. cerevisiae, this is the mitochondrial 21S rRNA synonym: "21S rRNA binding" NARROW [] synonym: "mitochondrial LSU rRNA binding" EXACT [] is_a: GO:0070180 ! large ribosomal subunit rRNA binding created_by: mcc creation_date: 2014-06-23T16:47:09Z [Term] id: GO:1990401 name: embryonic lung development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure." [PMID:24785085] is_a: GO:0048568 ! embryonic organ development created_by: sl creation_date: 2014-06-23T19:56:13Z [Term] id: GO:1990402 name: embryonic liver development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure." [PMID:15918910] is_a: GO:0048568 ! embryonic organ development created_by: sl creation_date: 2014-06-23T20:52:03Z [Term] id: GO:1990403 name: embryonic brain development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910] is_a: GO:0048568 ! embryonic organ development created_by: sl creation_date: 2014-06-23T20:57:13Z [Term] id: GO:1990404 name: protein ADP-ribosylase activity namespace: molecular_function def: "The transfer, from NAD, of ADP-ribose to a protein amino acid residue." [PMID:1899243, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295, wikipedia:ADP-ribosylation] synonym: "ribosylase activity" BROAD [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006471 ! protein ADP-ribosylation created_by: pg creation_date: 2014-06-24T07:04:44Z [Term] id: GO:1990405 name: protein antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein antigen." [PMID:9360996] is_a: GO:0003823 ! antigen binding is_a: GO:0005515 ! protein binding created_by: pm creation_date: 2014-06-30T13:19:55Z [Term] id: GO:1990406 name: CGRP receptor complex namespace: cellular_component def: "A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP)." [GOC:bhm, PMID:20826335] comment: An example of this is CALCRL in human (Q16602) in PMID:20826335 (inferred from direct assay). synonym: "calcitonin gene-related polypeptide receptor complex" EXACT [] synonym: "Calcitonin-gene-related peptide receptor complex" EXACT [] synonym: "CGRP-R complex" EXACT [] xref: IntAct:EBI-9009008 is_a: GO:1903439 ! calcitonin family receptor complex created_by: bhm creation_date: 2014-07-01T14:57:43Z [Term] id: GO:1990407 name: calcitonin gene-related peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitonin gene-related peptide (CGRP)." [GOC:bhm, PMID:10882736] comment: An example of this is CALCRL in human (Q16602) in PMID:10882736 (inferred from direct assay/mutant phenotype/etc.). synonym: "calcitonin-gene-related peptide binding" EXACT [] synonym: "calcitonin-gene-related polypeptide binding" EXACT [] synonym: "CGRP polypeptide binding" EXACT [] is_a: GO:0097644 ! calcitonin family binding created_by: bhm creation_date: 2014-07-02T14:22:06Z [Term] id: GO:1990408 name: calcitonin gene-related peptide receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers." [GOC:bhm, PMID:10882736] comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. synonym: "calcitonin-gene-related peptide receptor signaling pathway" EXACT [] synonym: "calcitonin-gene-related polypeptide receptor signaling pathway" EXACT [] synonym: "CGRP receptor signaling pathway" EXACT [] is_a: GO:0097646 ! calcitonin family receptor signaling pathway created_by: bhm creation_date: 2014-07-02T14:32:37Z [Term] id: GO:1990409 name: adrenomedullin binding namespace: molecular_function def: "Interacting selectively and non-covalently with adrenomedullin (AM)." [GOC:bhm, PMID:10882736] comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. synonym: "AM binding" EXACT [] is_a: GO:0097644 ! calcitonin family binding created_by: bhm creation_date: 2014-07-02T14:37:19Z [Term] id: GO:1990410 name: adrenomedullin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell." [GOC:bhm, PMID:10882736] comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. synonym: "AM receptor signaling pathway" EXACT [] is_a: GO:0097646 ! calcitonin family receptor signaling pathway created_by: bhm creation_date: 2014-07-02T14:43:31Z [Term] id: GO:1990411 name: hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) namespace: molecular_function def: "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium." [PMID:24828577] xref: MetaCyc:RXN-14428 xref: RHEA:42688 is_a: GO:0016846 ! carbon-sulfur lyase activity relationship: part_of GO:0052699 ! ergothioneine biosynthetic process created_by: mah creation_date: 2014-07-02T15:45:43Z [Term] id: GO:1990412 name: hercynylselenocysteine lyase activity (selenoneine-forming) namespace: molecular_function def: "Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium." [PMID:24828577] xref: RHEA:42696 is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: mah creation_date: 2014-07-02T15:51:07Z [Term] id: GO:1990413 name: eyespot apparatus namespace: cellular_component def: "A small pigmented organelle used in single-celled organisms to detect light." [Wikipedia:Eyespot_apparatus] synonym: "eyespot" RELATED [] synonym: "stigma" RELATED [] is_a: GO:0043229 ! intracellular organelle created_by: cjm creation_date: 2014-07-03T21:26:24Z [Term] id: GO:1990414 name: replication-born double-strand break repair via sister chromatid exchange namespace: biological_process def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [PMID:12820977, PMID:16888651\,GOC\:rb] synonym: "replication-born DSB repair by SCE" EXACT [] is_a: GO:0000724 ! double-strand break repair via homologous recombination created_by: rb creation_date: 2014-07-10T21:20:34Z [Term] id: GO:1990415 name: Pex17p-Pex14p docking complex namespace: cellular_component def: "A protein complex involved in the peroxisomal import machinery. In S. cerevisiae, this complex contains the proteins Pex17p, Pex14p, Pex19, and Pex13p." [GOC:rb, PMID:12667447] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2014-07-10T21:43:31Z [Term] id: GO:1990416 name: cellular response to brain-derived neurotrophic factor stimulus namespace: biological_process def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus." [PMID:21958434] synonym: "cellular response to BDNF stimulus" EXACT [] is_a: GO:1990090 ! cellular response to nerve growth factor stimulus created_by: sl creation_date: 2014-07-11T17:55:59Z [Term] id: GO:1990417 name: snoRNA release from pre-rRNA namespace: biological_process def: "The release of snoRNA from pre-rRNA." [GOC:rb, PMID:16908538] comment: An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay. is_a: GO:0006364 ! rRNA processing created_by: rb creation_date: 2014-07-11T21:43:27Z [Term] id: GO:1990418 name: response to insulin-like growth factor stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:21932665] is_a: GO:0009725 ! response to hormone created_by: sl creation_date: 2014-07-14T22:47:59Z [Term] id: GO:1990419 name: obsolete response to elemental metal namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus." [PMID:22688007] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to elemental metal" EXACT [] is_obsolete: true created_by: sl creation_date: 2014-07-15T20:17:56Z [Term] id: GO:1990420 name: establishment of septation initiation network asymmetry namespace: biological_process def: "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies." [PMID:22786806] synonym: "establishment of SIN asymmetry" EXACT [PMID:22786806] is_a: GO:0031028 ! septation initiation signaling created_by: al creation_date: 2014-07-16T13:51:36Z [Term] id: GO:1990421 name: subtelomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the subtelomeric regions." [PMID:18761674, SO:0001997] synonym: "sub-telomeric heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin created_by: mah creation_date: 2014-07-18T13:32:59Z [Term] id: GO:1990422 name: glyoxalase (glycolic acid-forming) activity namespace: molecular_function def: "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor." [GOC:bf, GOC:PARL, PMID:22523093] is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0046295 ! glycolate biosynthetic process relationship: part_of GO:1903190 ! glyoxal catabolic process created_by: bf creation_date: 2014-07-21T09:00:21Z [Term] id: GO:1990423 name: RZZ complex namespace: cellular_component def: "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495] comment: Example annotations for this term would be D. melanogaster mit(1)15 (Q9W4X9), rod and zwilch (Q9VA00). synonym: "Rod-Zwilch-Zw10 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0000776 ! kinetochore created_by: jl creation_date: 2014-07-23T11:16:42Z [Term] id: GO:1990424 name: protein arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate." [GOC:imk, PMID:22517742] comment: This reaction occurs in bacterial species e.g. Bacillus subtilis. is_a: GO:0004672 ! protein kinase activity created_by: jl creation_date: 2014-07-23T13:35:56Z [Term] id: GO:1990425 name: ryanodine receptor complex namespace: cellular_component def: "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom." [GOC:ame, PMID:22822064] comment: An example of this is RyR1 in rabbit (P11716) in PMID:2550460 (inferred from electron microscopy). synonym: "RyR" RELATED [] xref: IntAct:EBI-9632656 is_a: GO:0005891 ! voltage-gated calcium channel complex relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane created_by: anm creation_date: 2014-07-24T09:36:41Z [Term] id: GO:1990426 name: mitotic recombination-dependent replication fork processing namespace: biological_process def: "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942] synonym: "homologous recombination dependent replication fork recovery" RELATED [PMID:23093942] synonym: "homologous recombination-dependent replication fork processing" EXACT [] is_a: GO:0031297 ! replication fork processing is_a: GO:1990505 ! mitotic DNA replication maintenance of fidelity relationship: has_part GO:0006312 ! mitotic recombination created_by: mah creation_date: 2014-07-24T09:42:54Z [Term] id: GO:1990427 name: stereocilia tip-link density namespace: cellular_component def: "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane." [PMID:19447093, PMID:21709241] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0002140 ! stereocilia tip link relationship: part_of GO:0042995 ! cell projection created_by: sl creation_date: 2014-07-25T20:55:36Z [Term] id: GO:1990428 name: miRNA transport namespace: biological_process def: "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GO:jl, PMID:24356509] synonym: "microRNA transport" EXACT [] is_a: GO:0050658 ! RNA transport created_by: jl creation_date: 2014-07-29T14:03:46Z [Term] id: GO:1990429 name: peroxisomal importomer complex namespace: cellular_component def: "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:20154681, PMID:22375831] synonym: "peroxisomal import pore" EXACT [] synonym: "peroxisomal protein import machinery" EXACT [] synonym: "Pex14 complex" NARROW [] is_a: GO:1990351 ! transporter complex is_a: GO:1990415 ! Pex17p-Pex14p docking complex created_by: jl creation_date: 2014-07-29T14:45:28Z [Term] id: GO:1990430 name: extracellular matrix protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein that is part of an extracellular matrix." [PMID:22355679] is_a: GO:0005515 ! protein binding created_by: jl creation_date: 2014-07-29T14:57:07Z [Term] id: GO:1990431 name: priRNA 3'-end processing namespace: biological_process def: "The process of forming the mature 3' end of a priRNA molecule." [PMID:24095277] synonym: "primal small RNA 3'-end processing" EXACT [] synonym: "priRNA 3' end processing" EXACT [] is_a: GO:0043628 ! ncRNA 3'-end processing created_by: jl creation_date: 2014-07-29T15:34:19Z [Term] id: GO:1990432 name: siRNA 3'-end processing namespace: biological_process def: "The process of forming the mature 3' end of a siRNA molecule." [PMID:24095277] synonym: "siRNA 3' end processing" EXACT [] synonym: "small interfering RNA 3'-end processing" EXACT [] is_a: GO:0043628 ! ncRNA 3'-end processing created_by: jl creation_date: 2014-07-29T15:38:38Z [Term] id: GO:1990433 name: CSL-Notch-Mastermind transcription factor complex namespace: cellular_component def: "A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes." [GOC:bhm, GOC:dos, PMID:16530045] synonym: "CSL-NotchIC-MASTERMIND complex" EXACT [] xref: IntAct:EBI-9636287 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2014-07-30T14:41:43Z [Term] id: GO:1990434 name: lower tip-link density namespace: cellular_component def: "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises." [PMID:19447093] synonym: "LTLD" EXACT [] is_a: GO:1990427 ! stereocilia tip-link density created_by: sl creation_date: 2014-07-30T16:34:34Z [Term] id: GO:1990435 name: upper tip-link density namespace: cellular_component def: "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends." [PMID:19447093] synonym: "UTLD" EXACT [] is_a: GO:1990427 ! stereocilia tip-link density created_by: sl creation_date: 2014-07-30T16:36:32Z [Term] id: GO:1990436 name: obsolete MAPK cascade involved in oxidative stress signaling pathway namespace: biological_process def: "OBSOLETE. A series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term." [PMID:10398679] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "MAPK cascade involved in oxidative stress signaling pathway" EXACT [] is_obsolete: true created_by: al creation_date: 2014-07-31T10:10:38Z [Term] id: GO:1990437 name: snRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635] is_a: GO:0001510 ! RNA methylation is_a: GO:0040031 ! snRNA modification created_by: mah creation_date: 2014-07-31T11:58:18Z [Term] id: GO:1990438 name: U6 2'-O-snRNA methylation namespace: biological_process def: "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635] is_a: GO:1990437 ! snRNA 2'-O-methylation created_by: mah creation_date: 2014-07-31T12:04:21Z [Term] id: GO:1990439 name: MAP kinase serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate." [PMID:10398679] is_a: GO:0004722 ! protein serine/threonine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity created_by: al creation_date: 2014-07-31T12:21:04Z [Term] id: GO:1990440 name: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145] synonym: "activation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] synonym: "ER stress-induced upregulation of transcription" BROAD [GOC:bf] synonym: "stimulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] synonym: "up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "up-regulation of transcription induced by ER stress" BROAD [GOC:bf, PMID:21113145] synonym: "upregulation of Pol II transcription induced by ER stress" EXACT [GOC:bf, PMID:21113145] synonym: "upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress created_by: bf creation_date: 2014-07-31T12:56:54Z [Term] id: GO:1990441 name: negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145] synonym: "down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "ER stress-induced negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] synonym: "inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] synonym: "negative regulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] synonym: "reduction of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] synonym: "repression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] synonym: "suppression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress created_by: bf creation_date: 2014-07-31T13:08:54Z [Term] id: GO:1990442 name: intrinsic apoptotic signaling pathway in response to nitrosative stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:bf, GOC:PARL, PMID:23985028] synonym: "nitrosative stress-induced apoptosis" RELATED [PMID:23985028] synonym: "nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] is_a: GO:0071500 ! cellular response to nitrosative stress is_a: GO:0097193 ! intrinsic apoptotic signaling pathway created_by: bf creation_date: 2014-07-31T14:28:16Z [Term] id: GO:1990443 name: peptidyl-threonine autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein." [PMID:7803855] is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:0046777 ! protein autophosphorylation created_by: al creation_date: 2014-08-02T15:08:41Z [Term] id: GO:1990444 name: F-box domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165] is_a: GO:0019904 ! protein domain specific binding created_by: bf creation_date: 2014-08-05T13:45:14Z [Term] id: GO:1990445 name: obsolete Multiciliate cell differentiation namespace: biological_process def: "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems." [PMID:22231168, PMID:24934224] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "Multiciliate cell differentiation" EXACT [] is_obsolete: true created_by: sp creation_date: 2014-08-05T14:31:28Z [Term] id: GO:1990446 name: U1 snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle." [PMID:14713954] is_a: GO:0070990 ! snRNP binding created_by: mah creation_date: 2014-08-06T09:29:44Z [Term] id: GO:1990447 name: U2 snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a U2 small nuclear ribonucleoprotein particle." [PMID:14713954] is_a: GO:0070990 ! snRNP binding created_by: mah creation_date: 2014-08-06T09:33:38Z [Term] id: GO:1990448 name: exon-exon junction complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [GOC:sart, PMID:24967911] synonym: "EJC binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: sart creation_date: 2014-08-06T10:02:46Z [Term] id: GO:1990449 name: obsolete amylin receptor namespace: cellular_component def: "OBSOLETE. A G protein-coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss." [GOC:bhm, PMID:10871269] comment: An example of this is CALCR in human (P30988) in PMID:10871269. synonym: "AMY1 receptor" NARROW [] synonym: "AMY2 receptor" NARROW [] synonym: "AMY3 receptor" NARROW [] synonym: "amylin receptor" EXACT [] synonym: "CALCR-RAMP1 receptor" NARROW [] synonym: "CALCR-RAMP2 receptor" NARROW [] synonym: "CALCR-RAMP3 receptor" NARROW [] xref: IntAct:EBI-9008682 xref: IntAct:EBI-9685417 xref: IntAct:EBI-9685439 is_obsolete: true created_by: bhm creation_date: 2014-08-06T10:21:37Z [Term] id: GO:1990450 name: linear polyubiquitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807] synonym: "M1-linked ubiquitin chain binding" EXACT [PMID:23453807] is_a: GO:0043130 ! ubiquitin binding created_by: bf creation_date: 2014-08-06T11:10:26Z [Term] id: GO:1990451 name: cellular stress response to acidic pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution." [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049] comment: An example of this is NOX1 in human (Q9Y5S8) in PMID:10615049. synonym: "cellular stress response to acidity" BROAD [] is_a: GO:0062197 ! cellular response to chemical stress is_a: GO:0071468 ! cellular response to acidic pH created_by: jl creation_date: 2014-08-06T14:06:58Z [Term] id: GO:1990452 name: Parkin-FBXW7-Cul1 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] synonym: "Park2-FBXW7-Cul1 complex" EXACT [GOC:bf] synonym: "Parkin-FBXW7-Cul1 protein complex" EXACT [GOC:bf] synonym: "Parkin-HSel-10-Cullin-1 complex" NARROW [PMID:12628165] synonym: "Parkin/Cul1/F-box protein complex" EXACT [GOC:bf] synonym: "PRKN-FBXW7-Cul1 complex" EXACT [] is_a: GO:0000151 ! ubiquitin ligase complex created_by: bf creation_date: 2014-08-07T14:25:49Z [Term] id: GO:1990453 name: nucleosome disassembly/reassembly complex namespace: cellular_component def: "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex." [GOC:bhm, PMID:24843044] comment: An example of this is EAF7 in Saccharomyces cerevisiae (P53911) in PMID:24843044 (inferred from direct assay). synonym: "eaf5/7/3 complex" NARROW [] xref: IntAct:EBI-9682603 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus created_by: bhm creation_date: 2014-08-08T15:18:30Z [Term] id: GO:1990454 name: L-type voltage-gated calcium channel complex namespace: cellular_component def: "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation." [GOC:ame, PMID:12946355] comment: Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay). synonym: "cardiac muscle L-type voltage-gated calcium channel complex" NARROW [] synonym: "skeletal muscle L-type voltage-gated calcium channel complex" NARROW [] is_a: GO:0005891 ! voltage-gated calcium channel complex relationship: part_of GO:0030315 ! T-tubule created_by: anm creation_date: 2014-08-12T17:22:10Z [Term] id: GO:1990455 name: PTEN phosphatase complex namespace: cellular_component def: "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function." [GOC:bhm, PMID:24766807] comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). synonym: "phosphatase and tensin homolog" EXACT [] synonym: "phosphatase and tensin homolog deleted on chromosome ten homodimer" EXACT [] synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer" EXACT [] xref: IntAct:EBI-9637198 xref: IntAct:EBI-9637224 is_a: GO:1904144 ! phosphatidylinositol phosphate phosphatase complex created_by: bhm creation_date: 2014-08-13T10:21:20Z [Term] id: GO:1990456 name: mitochondrion-endoplasmic reticulum membrane tethering namespace: biological_process def: "The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:19556461] {comment="PMID:27875684"} synonym: "mitochondrion-endoplasmic reticulum attachment" EXACT [] synonym: "mitochondrion-endoplasmic reticulum tethering" EXACT [] synonym: "mitochondrion-ER attachment" EXACT [] synonym: "mitochondrion-ER membrane tethering" EXACT [] synonym: "mitochondrion-ER tethering" EXACT [] is_a: GO:0016043 ! cellular component organization is_a: GO:0140056 ! organelle localization by membrane tethering created_by: mcc creation_date: 2014-08-14T13:32:30Z [Term] id: GO:1990457 name: pexophagosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy." [PMID:22536249] is_a: GO:0045335 ! phagocytic vesicle created_by: dhl creation_date: 2014-08-15T18:51:53Z [Term] id: GO:1990458 name: lipooligosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria." [GOC:hjd, PMID:8894399] comment: ChEBI distinguishes an oligosaccharide from a polysaccharide as the latter being anything of length 10 or greater. synonym: "endotoxin binding" RELATED [] synonym: "LOS binding" RELATED [] is_a: GO:0097367 ! carbohydrate derivative binding created_by: hjd creation_date: 2014-08-15T19:58:08Z [Term] id: GO:1990459 name: transferrin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the transferrin receptor." [GOC:pm, PMID:9819414] is_a: GO:0005102 ! signaling receptor binding created_by: tb creation_date: 2014-08-18T20:14:24Z [Term] id: GO:1990460 name: leptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the leptin receptor." [GOC:pm, PMID:22405007] is_a: GO:0005102 ! signaling receptor binding created_by: tb creation_date: 2014-08-18T20:17:43Z [Term] id: GO:1990461 name: detoxification of iron ion namespace: biological_process def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:0010039 ! response to iron ion created_by: sart creation_date: 2014-08-19T10:12:46Z [Term] id: GO:1990462 name: omegasome namespace: cellular_component def: "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649] is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0012505 ! endomembrane system created_by: pr creation_date: 2014-08-19T12:26:40Z [Term] id: GO:1990463 name: lateral cortical node namespace: cellular_component def: "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287] synonym: "Skb1-containing cortical node" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0097575 ! lateral cell cortex created_by: pr creation_date: 2014-08-20T09:04:45Z [Term] id: GO:1990464 name: D-2-hydroxyacid dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol." [EC:1.1.5.10, GOC:am, PMID:3013300, PMID:4582730] comment: (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. synonym: "(R)-2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.5.10] synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.5.10] synonym: "(R)-2-hydroxyacid:quinone oxidoreductase activity" EXACT [EC:1.1.5.10] synonym: "D-lactate dehydrogenase (quinone) activity" RELATED [GOC:am] synonym: "D-lactate dehydrogenase activity" RELATED [EC:1.1.5.10] synonym: "D-lactate:quinone oxidoreductase activity" RELATED [GOC:am] is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor created_by: pr creation_date: 2014-08-22T10:13:42Z [Term] id: GO:1990465 name: aldehyde oxygenase (deformylating) activity namespace: molecular_function def: "Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+)." [GOC:mengo_curators, PMID:22947199, RHEA:21440] xref: EC:4.1.99.5 xref: RHEA:21440 is_a: GO:0016830 ! carbon-carbon lyase activity created_by: tt creation_date: 2014-08-25T15:16:43Z [Term] id: GO:1990466 name: protein autosumoylation namespace: biological_process def: "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663] synonym: "protein auto-sumoylation" EXACT [] synonym: "protein self-sumoylation" EXACT [] is_a: GO:0016925 ! protein sumoylation created_by: se creation_date: 2014-08-25T22:37:21Z [Term] id: GO:1990467 name: NuA3a histone acetyltransferase complex namespace: cellular_component def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p." [GOC:rb, PMID:25104842] is_a: GO:0033100 ! NuA3 histone acetyltransferase complex created_by: rb creation_date: 2014-08-25T23:07:45Z [Term] id: GO:1990468 name: NuA3b histone acetyltransferase complex namespace: cellular_component def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p." [GOC:rb, PMID:25104842] is_a: GO:0033100 ! NuA3 histone acetyltransferase complex created_by: rb creation_date: 2014-08-25T23:13:37Z [Term] id: GO:1990469 name: Rhino-Deadlock-Cutoff Complex namespace: cellular_component def: "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation." [GOC:bhm, PMID:24906153] comment: An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153. synonym: "RDC complex" EXACT [] synonym: "rhi-del-cuff complex" EXACT [] xref: IntAct:EBI-9694217 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0043073 ! germ cell nucleus created_by: bhm creation_date: 2014-08-29T14:08:37Z [Term] id: GO:1990470 name: piRNA cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)." [GOC:bhm, PMID:24906153] comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). is_a: GO:1990837 ! sequence-specific double-stranded DNA binding created_by: bhm creation_date: 2014-08-29T14:23:38Z [Term] id: GO:1990471 name: piRNA uni-strand cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa." [GOC:bhm, PMID:24906153] is_a: GO:1990470 ! piRNA cluster binding created_by: bhm creation_date: 2014-08-29T14:37:35Z [Term] id: GO:1990472 name: piRNA dual-strand cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription." [GOC:bhm, PMID:24906153] comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). is_a: GO:1990470 ! piRNA cluster binding created_by: bhm creation_date: 2014-08-29T14:50:54Z [Term] id: GO:1990473 name: ciliary targeting signal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane." [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559] synonym: "CTS binding" EXACT [] is_a: GO:0005048 ! signal sequence binding created_by: pr creation_date: 2014-09-02T08:22:03Z [Term] id: GO:1990474 name: synaptic vesicle, readily releasable pool namespace: cellular_component def: "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton." [GOC:pad, PMID:22745285] synonym: "readily releasable pool of synaptic vesicles" EXACT [] synonym: "RRP" RELATED [] is_a: GO:0008021 ! synaptic vesicle relationship: part_of GO:0043195 ! terminal bouton created_by: pr creation_date: 2014-09-02T09:02:41Z [Term] id: GO:1990475 name: synaptic vesicle, recycling pool namespace: cellular_component def: "A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state." [GOC:pad, PMID:22745285] synonym: "recycling pool of synaptic vesicles" EXACT [] is_a: GO:0008021 ! synaptic vesicle relationship: part_of GO:0098794 ! postsynapse created_by: pr creation_date: 2014-09-02T09:08:22Z [Term] id: GO:1990476 name: synaptic vesicle, resting pool namespace: cellular_component def: "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool." [GOC:pad, PMID:22745285] synonym: "reserve pool of synaptic vesicles" EXACT [PMID:15611727] synonym: "resting pool of synaptic vesicles" EXACT [] is_a: GO:0008021 ! synaptic vesicle relationship: part_of GO:0043195 ! terminal bouton created_by: pr creation_date: 2014-09-02T09:12:37Z [Term] id: GO:1990477 name: NURS complex namespace: cellular_component def: "The nuclear RNA silencing (NURS) complex is a protein complex formed by Red1, Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2 that regulates RNA degradation and histone H3 lysine 9 methylation. It is likely related to the human CBCN complex." [PMID:24713849] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990345 ! MTREC complex created_by: al creation_date: 2014-09-04T14:46:54Z [Term] id: GO:1990478 name: response to ultrasound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus." [PMID:20950932] is_a: GO:0009612 ! response to mechanical stimulus created_by: sl creation_date: 2014-09-09T22:11:32Z [Term] id: GO:1990479 name: obsolete response to lipoic acid namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [PMID:23232760] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to 5-(1,2-dithiolan-3-yl)pentanoic acid" EXACT [] is_obsolete: true created_by: sl creation_date: 2014-09-09T22:20:41Z [Term] id: GO:1990480 name: obsolete geranyl diphosphate synthase namespace: molecular_function def: "OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis." [GOC:mengo_curators, PMID:10557273] comment: This term was obsoleted at the TermGenie Gatekeeper stage. xref: PMID:10557273 is_obsolete: true replaced_by: GO:0004161 created_by: tt creation_date: 2014-09-10T01:14:17Z [Term] id: GO:1990481 name: mRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136] synonym: "mRNA pseudouridylation" EXACT [] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0016556 ! mRNA modification created_by: mcc creation_date: 2014-09-12T15:13:39Z [Term] id: GO:1990482 name: sphingolipid alpha-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC." [GOC:tb, PMID:25122154] synonym: "inositol phosphorylceramide glucuronosyltransferase activity" RELATED [] is_a: GO:0008194 ! UDP-glycosyltransferase activity created_by: tb creation_date: 2014-09-12T22:10:09Z [Term] id: GO:1990483 name: Clr6 histone deacetylase complex I'' namespace: cellular_component def: "A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3." [PMID:25002536] is_a: GO:0000118 ! histone deacetylase complex relationship: part_of GO:0000790 ! nuclear chromatin created_by: al creation_date: 2014-09-16T10:40:51Z [Term] id: GO:1990484 name: aerobic lactate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen." [GOC:mengo_curators, PMID:8941775] synonym: "aerobic lactic acid catabolic process" RELATED [] is_a: GO:1903457 ! lactate catabolic process created_by: tt creation_date: 2014-09-20T05:42:51Z [Term] id: GO:1990485 name: anaerobic lactate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen." [GOC:mengo_curators, PMID:11133436] synonym: "anaerobic lactic acid catabolic process" RELATED [] is_a: GO:1903457 ! lactate catabolic process created_by: tt creation_date: 2014-09-20T16:48:06Z [Term] id: GO:1990486 name: anaerobic fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mengo_curators, PMID:17329794] synonym: "anaerobic fatty acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process created_by: tt creation_date: 2014-09-20T17:25:48Z [Term] id: GO:1990487 name: anaerobic lignin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units." [DOI:10.1039/C3EE40932E, GOC:mengo_curators] synonym: "anaerobic lignin degradation" EXACT [] is_a: GO:0046274 ! lignin catabolic process created_by: tt creation_date: 2014-09-20T17:35:09Z [Term] id: GO:1990488 name: anaerobic cellulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen." [GOC:mengo_curators, PMID:8561466] synonym: "anaerobic cellulose degradation" EXACT [] is_a: GO:0030245 ! cellulose catabolic process created_by: tt creation_date: 2014-09-20T17:43:59Z [Term] id: GO:1990489 name: anaerobic pectin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." [GOC:mengo_curators, PMID:23079077] synonym: "anaerobic pectin degradation" EXACT [] is_a: GO:0045490 ! pectin catabolic process created_by: tt creation_date: 2014-09-20T18:09:53Z [Term] id: GO:1990490 name: archaeal proton-transporting A-type ATPase complex namespace: cellular_component def: "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." [GOC:mengo_curators, PMID:15473999, PMID:24650628] synonym: "A-type ATPase protein complex" BROAD [] synonym: "archaeal A-type ATPase protein complex" BROAD [] is_a: GO:0016469 ! proton-transporting two-sector ATPase complex created_by: tt creation_date: 2014-09-20T19:13:55Z [Term] id: GO:1990491 name: methane biosynthetic process from methanol and hydrogen namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen." [GOC:mengo_curators, PMID:16347126] synonym: "methane biosynthesis from methanol and hydrogen" EXACT [] synonym: "methanogenesis from methanol and hydrogen" EXACT [] is_a: GO:0015945 ! methanol metabolic process is_a: GO:0019387 ! methanogenesis, from methanol is_a: GO:1902421 ! hydrogen metabolic process created_by: tt creation_date: 2014-09-21T01:08:40Z [Term] id: GO:1990492 name: mitotic cell cycle checkpoint inhibiting CAR assembly namespace: biological_process def: "A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase." [PMID:12186944] synonym: "Mad2-dependent mitotic cell cycle checkpoint" RELATED [GOC:dph, GOC:vw] synonym: "mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly" EXACT [] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly created_by: vw creation_date: 2014-09-23T12:43:22Z [Term] id: GO:1990493 name: obsolete cyclin H-CDK7 complex namespace: cellular_component def: "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:9857180] comment: This term was made obsolete because it was added in error. synonym: "cyclin H-CDK7 complex" EXACT [] is_obsolete: true created_by: al creation_date: 2014-09-24T10:08:44Z [Term] id: GO:1990494 name: obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly." [PMID:18256290] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] is_obsolete: true created_by: al creation_date: 2014-09-25T09:04:55Z [Term] id: GO:1990495 name: obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:8834798] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT [] is_obsolete: true created_by: al creation_date: 2014-09-25T09:19:27Z [Term] id: GO:1990496 name: obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:24798735] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT [] is_obsolete: true created_by: al creation_date: 2014-09-25T09:21:57Z [Term] id: GO:1990497 name: regulation of cytoplasmic translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:2000765 ! regulation of cytoplasmic translation created_by: vw creation_date: 2014-09-26T11:11:29Z [Term] id: GO:1990498 name: mitotic spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] is_a: GO:0005876 ! spindle microtubule relationship: part_of GO:0072686 ! mitotic spindle created_by: vw creation_date: 2014-09-26T13:34:40Z [Term] id: GO:1990499 name: raps-insc complex namespace: cellular_component def: "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2)." [GOC:bhm, PMID:22171003] comment: An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction). synonym: "partner of inscuteable-inscuteable complex" EXACT [] synonym: "Rapsynoid-Inscuteable complex" EXACT [] xref: IntAct:EBI-9674411 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0045179 ! apical cortex created_by: bhm creation_date: 2014-09-30T09:22:18Z [Term] id: GO:1990500 name: eif4e-cup complex namespace: cellular_component def: "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo." [GOC:bhm, PMID:14723848] comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). synonym: "eukaryotic translation initiation factor 4E-cup complex" EXACT [] xref: IntAct:EBI-9674930 is_a: GO:1903502 ! translation repressor complex relationship: part_of GO:0000932 ! P-body created_by: bhm creation_date: 2014-09-30T12:31:49Z [Term] id: GO:1990501 name: exon-exon junction subcomplex mago-y14 namespace: cellular_component def: "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, PMID:12730685] comment: An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay). synonym: "exon junction subcomplex MAGOH-Y14" EXACT [GOC:bhm] synonym: "mago-y14 complex" RELATED [] synonym: "MGN-RBM8A complex" EXACT [] xref: IntAct:EBI-9549962 is_a: GO:0035145 ! exon-exon junction complex is_a: GO:1903503 ! ATPase inhibitor complex created_by: bhm creation_date: 2014-09-30T14:05:28Z [Term] id: GO:1990502 name: dense core granule maturation namespace: biological_process def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] synonym: "dense core vesicle maturation" EXACT [] is_a: GO:0061792 ! secretory granule maturation created_by: kmv creation_date: 2014-09-30T20:35:11Z [Term] id: GO:1990503 name: dendritic lamellar body namespace: cellular_component def: "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions." [PMID:7869120] synonym: "DLB" EXACT [] is_a: GO:0042599 ! lamellar body relationship: part_of GO:0030425 ! dendrite created_by: sl creation_date: 2014-09-30T20:47:28Z [Term] id: GO:1990504 name: dense core granule exocytosis namespace: biological_process def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] synonym: "dense core vesicle exocytosis" EXACT [] is_a: GO:0017156 ! calcium-ion regulated exocytosis created_by: kmv creation_date: 2014-09-30T21:05:50Z [Term] id: GO:1990505 name: mitotic DNA replication maintenance of fidelity namespace: biological_process alt_id: GO:1990510 def: "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." [PMID:19185548] synonym: "maintenance of fidelity involved in mitotic cell cycle DNA replication" EXACT [] synonym: "maintenance of fidelity involved in mitotic DNA replication" EXACT [] synonym: "mitotic DNA replication maintenance of fidelity" EXACT [] is_a: GO:1902298 ! cell cycle DNA replication maintenance of fidelity is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902298 ! cell cycle DNA replication maintenance of fidelity intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:1902969 ! mitotic DNA replication created_by: al creation_date: 2014-10-01T14:09:05Z [Term] id: GO:1990506 name: mitotic DNA-dependent DNA replication namespace: biological_process def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle." [PMID:16120966] is_a: GO:1902969 ! mitotic DNA replication created_by: al creation_date: 2014-10-01T14:13:23Z [Term] id: GO:1990507 name: ATP-independent chaperone mediated protein folding namespace: biological_process def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis." [GOC:rb, PMID:25242142] is_a: GO:0061077 ! chaperone-mediated protein folding created_by: rb creation_date: 2014-10-01T23:55:05Z [Term] id: GO:1990508 name: CKM complex namespace: cellular_component def: "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." [GOC:bhm, PMID:12200444] comment: An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction). synonym: "CDK8 kinase module" EXACT [] synonym: "SRB8-SRB11 complex" EXACT [] synonym: "SRB8/9/10/11 complex" EXACT [] xref: IntAct:EBI-2640924 is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex created_by: bhm creation_date: 2014-10-02T10:05:58Z [Term] id: GO:1990509 name: PYM-mago-Y14 complex namespace: cellular_component def: "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans." [GOC:bhm, PMID:14968132] comment: An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction). synonym: "PYM-mago-RNA-binding protein 8A complex" EXACT [] synonym: "wibg-mago-tsu complex" EXACT [] xref: IntAct:EBI-9634190 is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990501 ! exon-exon junction subcomplex mago-y14 created_by: bhm creation_date: 2014-10-03T12:52:01Z [Term] id: GO:1990511 name: piRNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:24696457] synonym: "Piwi-associated RNA biosynthetic process" EXACT [] is_a: GO:0034587 ! piRNA metabolic process created_by: kmv creation_date: 2014-10-07T13:47:32Z [Term] id: GO:1990512 name: Cry-Per complex namespace: cellular_component def: "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms." [GOC:bhm, PMID:24855952] comment: An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction). xref: IntAct:EBI-9693126 xref: IntAct:EBI-9693260 xref: IntAct:EBI-9694282 xref: IntAct:EBI-9695878 xref: IntAct:EBI-9695921 xref: IntAct:EBI-9695942 xref: IntAct:EBI-9696219 xref: IntAct:EBI-9696270 xref: IntAct:EBI-9696293 xref: IntAct:EBI-9696310 xref: IntAct:EBI-9696328 xref: IntAct:EBI-9696345 is_a: GO:0090568 ! nuclear transcriptional repressor complex created_by: bhm creation_date: 2014-10-08T10:53:07Z [Term] id: GO:1990513 name: CLOCK-BMAL transcription complex namespace: cellular_component def: "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, PMID:23229515] comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction). synonym: "CLOCK/BMAL complex" EXACT [] xref: IntAct:EBI-9696362 xref: IntAct:EBI-9696901 xref: IntAct:EBI-9696921 xref: IntAct:EBI-9696951 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2014-10-08T13:10:24Z [Term] id: GO:1990514 name: 5' transitive RNA interference namespace: biological_process def: "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430] is_a: GO:0036453 ! transitive RNA interference created_by: jl creation_date: 2014-10-09T15:29:31Z [Term] id: GO:1990515 name: 3' transitive RNA interference namespace: biological_process def: "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430] is_a: GO:0036453 ! transitive RNA interference created_by: jl creation_date: 2014-10-09T15:31:01Z [Term] id: GO:1990516 name: ribonucleotide excision repair namespace: biological_process def: "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase." [PMID:12475934, PMID:22864116] is_a: GO:0070716 ! mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication created_by: al creation_date: 2014-10-14T12:24:37Z [Term] id: GO:1990517 name: obsolete protein localization to photoreceptor outer segment namespace: biological_process def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium." [GOC:krc, PMID:20212494] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: krc creation_date: 2014-10-14T14:01:34Z [Term] id: GO:1990518 name: single-stranded 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823] is_a: GO:0017116 ! single-stranded DNA helicase activity is_a: GO:0043138 ! 3'-5' DNA helicase activity created_by: al creation_date: 2014-10-22T10:17:40Z [Term] id: GO:1990519 name: pyrimidine nucleotide import into mitochondrion namespace: biological_process def: "The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150] synonym: "mitochondrial pyrimidine nucleotide import" EXACT [] is_a: GO:0006864 ! pyrimidine nucleotide transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-10-22T10:20:23Z [Term] id: GO:1990520 name: separase-securin complex namespace: cellular_component def: "A protein complex that includes separase (a protease which cleaves cohesin as part of mitotic sister chromatid separation) and securin, a protease inhibitor. Mitotic sister chromatid separation is inhibited until securin is degraded by the Anaphase Promoting Complex." [GOC:dos, GOC:vw, PMID:8978688] synonym: "Cut1-2 complex" EXACT [PMID:8978688] is_a: GO:1905369 ! endopeptidase complex created_by: vw creation_date: 2014-10-23T10:34:52Z [Term] id: GO:1990521 name: m7G(5')pppN diphosphatase activator activity namespace: molecular_function def: "Binds to and increases the activity of m7G(5')pppN diphosphatase." [PMID:22323607] is_a: GO:0008047 ! enzyme activator activity relationship: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity created_by: vw creation_date: 2014-10-23T11:20:56Z [Term] id: GO:1990522 name: tail spike morphogenesis namespace: biological_process def: "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death." [GOC:kmv, PMID:17329362, PMID:6684600] xref: WBbt:0006979 xref: WBbt:0008072 is_a: GO:0009653 ! anatomical structure morphogenesis created_by: jl creation_date: 2014-10-23T15:20:15Z [Term] id: GO:1990523 name: bone regeneration namespace: biological_process def: "The regrowth of bone following its loss or destruction." [PMID:25257467] is_a: GO:0042246 ! tissue regeneration created_by: sl creation_date: 2014-10-30T15:47:39Z [Term] id: GO:1990524 name: INA complex namespace: cellular_component def: "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p." [GOC:rn, PMID:24942160] synonym: "INAC" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0031304 ! intrinsic component of mitochondrial inner membrane created_by: jl creation_date: 2014-11-03T16:03:39Z [Term] id: GO:1990525 name: BIR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain." [GOC:ha, InterPro:IPR001370] comment: An example of this is the Drosophila reaper gene in PMID:21886178. synonym: "Baculovirus Inhibitor of apoptosis protein Repeat domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding created_by: jl creation_date: 2014-11-04T12:36:56Z [Term] id: GO:1990526 name: Ste12p-Dig1p-Dig2p complex namespace: cellular_component def: "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2014-11-05T22:49:32Z [Term] id: GO:1990527 name: Tec1p-Ste12p-Dig1p complex namespace: cellular_component def: "A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae." [GOC:rb, PMID:16782869] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2014-11-05T22:55:17Z [Term] id: GO:1990528 name: Rvs161p-Rvs167p complex namespace: cellular_component def: "A protein complex that is involved in endocytosis in the yeast S. cerevisiae." [GOC:rb, PMID:20610658] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2014-11-05T23:11:32Z [Term] id: GO:1990529 name: glycosylphosphatidylinositol-mannosyltransferase I complex namespace: cellular_component def: "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094] synonym: "GPI-MT-I complex" RELATED [] is_a: GO:0031501 ! mannosyltransferase complex relationship: part_of GO:0005783 ! endoplasmic reticulum created_by: rb creation_date: 2014-11-06T01:02:31Z [Term] id: GO:1990530 name: Cdc50p-Drs2p complex namespace: cellular_component def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome." [GOC:rb, PMID:15090616, PMID:22234261] is_a: GO:1990531 ! phospholipid-translocating ATPase complex created_by: rb creation_date: 2014-11-06T01:29:31Z [Term] id: GO:1990531 name: phospholipid-translocating ATPase complex namespace: cellular_component def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase." [GOC:dph, GOC:rb, PMID:15090616] synonym: "aminophospholipid translocase complex" EXACT [] synonym: "APLT complex" EXACT [] synonym: "CDC50-DRS2 complex" NARROW [] synonym: "CRF1-DNF3 complex" NARROW [] synonym: "Dnf1-Lem3 complex" NARROW [] synonym: "Dnf2-Lem3 complex" NARROW [] synonym: "DNF3-CRF1 complex" NARROW [] synonym: "DRS2-CDC50 complex" NARROW [] synonym: "Lem3-Dnf1 complex" NARROW [] synonym: "Lem3p-Dnf1p complex" NARROW [] synonym: "P4-ATPase complex" EXACT [] synonym: "phospholipid flippase complex" EXACT [] is_a: GO:1990351 ! transporter complex created_by: rb creation_date: 2014-11-06T22:33:25Z [Term] id: GO:1990532 name: stress response to nickel ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus." [GOC:kmv, PMID:25330323] synonym: "response to nickel ion stress" EXACT [] synonym: "response to nickel toxicity" EXACT [] synonym: "stress response to nickel" EXACT [] is_a: GO:0097501 ! stress response to metal ion created_by: kmv creation_date: 2014-11-07T18:35:31Z [Term] id: GO:1990533 name: Dom34-Hbs1 complex namespace: cellular_component def: "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425] synonym: "Dom34:Hbs1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: mcc creation_date: 2014-11-07T20:49:03Z [Term] id: GO:1990534 name: thermospermine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine." [PMID:24906355] is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor created_by: tb creation_date: 2014-11-13T00:41:59Z [Term] id: GO:1990535 name: neuron projection maintenance namespace: biological_process def: "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:kmv, PMID:25359212] synonym: "axon homeostasis" RELATED [] synonym: "axon maintenance" RELATED [] synonym: "neurite maintenance" NARROW [] synonym: "neuron process maintenance" EXACT [] synonym: "neuron protrusion maintenance" EXACT [] synonym: "neuronal cell projection maintenance" EXACT [] is_a: GO:0106027 ! neuron projection organization created_by: kmv creation_date: 2014-11-13T22:24:05Z [Term] id: GO:1990536 name: phosphoenolpyruvate transmembrane import into Golgi lumen namespace: biological_process def: "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane." [PMID:25195688] is_a: GO:0089722 ! phosphoenolpyruvate transmembrane transport created_by: vw creation_date: 2014-11-14T10:17:01Z [Term] id: GO:1990537 name: mitotic spindle polar microtubule namespace: cellular_component def: "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone." [PMID:16079915] is_a: GO:0005827 ! polar microtubule is_a: GO:1990498 ! mitotic spindle microtubule created_by: vw creation_date: 2014-11-14T15:32:38Z [Term] id: GO:1990538 name: xylan O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan." [PMID:25141999] is_a: GO:0016413 ! O-acetyltransferase activity created_by: tb creation_date: 2014-11-18T20:02:51Z [Term] id: GO:1990539 name: fructose import across plasma membrane namespace: biological_process def: "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] is_a: GO:0032445 ! fructose import is_a: GO:0140271 ! hexose import across plasma membrane created_by: vw creation_date: 2014-11-19T10:57:17Z [Term] id: GO:1990540 name: mitochondrial manganese ion transmembrane transport namespace: biological_process def: "The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12890866] is_a: GO:0071421 ! manganese ion transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T11:03:09Z [Term] id: GO:1990542 name: mitochondrial transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0055085 ! transmembrane transport created_by: vw creation_date: 2014-11-19T11:19:21Z [Term] id: GO:1990543 name: mitochondrial S-adenosyl-L-methionine transmembrane transport namespace: biological_process def: "The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14609944] is_a: GO:1901962 ! S-adenosyl-L-methionine transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T11:26:27Z [Term] id: GO:1990544 name: mitochondrial ATP transmembrane transport namespace: biological_process def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015867 ! ATP transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T11:43:33Z [Term] id: GO:1990545 name: mitochondrial thiamine pyrophosphate transmembrane transport namespace: biological_process def: "The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12411483] is_a: GO:0030974 ! thiamine pyrophosphate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T11:47:15Z [Term] id: GO:1990546 name: mitochondrial tricarboxylic acid transmembrane transport namespace: biological_process def: "The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw] is_a: GO:0035674 ! tricarboxylic acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:00:14Z [Term] id: GO:1990547 name: mitochondrial phosphate ion transmembrane transport namespace: biological_process def: "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] is_a: GO:0035435 ! phosphate ion transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T11:50:19Z [Term] id: GO:1990548 name: mitochondrial FAD transmembrane transport namespace: biological_process def: "The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14555654] is_a: GO:0035350 ! FAD transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:04:35Z [Term] id: GO:1990549 name: mitochondrial NAD transmembrane transport namespace: biological_process def: "The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:16291748] is_a: GO:0035352 ! NAD transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:09:51Z [Term] id: GO:1990550 name: mitochondrial alpha-ketoglutarate transmembrane transport namespace: biological_process alt_id: GO:1990552 def: "The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234, PMID:20371607] synonym: "mitochondrial 2-oxoglutarate transmembrane transport" EXACT [] is_a: GO:0015742 ! alpha-ketoglutarate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:11:59Z [Term] id: GO:1990551 name: mitochondrial 2-oxoadipate transmembrane transport namespace: biological_process def: "The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:25:48Z [Term] id: GO:1990553 name: mitochondrial 5'-adenylyl sulfate transmembrane transport namespace: biological_process def: "The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033] is_a: GO:1902558 ! 5'-adenylyl sulfate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:32:01Z [Term] id: GO:1990554 name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport namespace: biological_process def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033] is_a: GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:39:22Z [Term] id: GO:1990555 name: mitochondrial oxaloacetate transmembrane transport namespace: biological_process def: "The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] is_a: GO:1902356 ! oxaloacetate(2-) transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:45:37Z [Term] id: GO:1990556 name: mitochondrial isopropylmalate transmembrane transport namespace: biological_process def: "The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] is_a: GO:1902357 ! 2-isopropylmalate(2-) transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:47:11Z [Term] id: GO:1990557 name: mitochondrial sulfate transmembrane transport namespace: biological_process def: "The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] is_a: GO:1902358 ! sulfate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:49:35Z [Term] id: GO:1990558 name: mitochondrial malonate(1-) transmembrane transport namespace: biological_process def: "The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] is_a: GO:1901553 ! malonic acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:52:43Z [Term] id: GO:1990559 name: mitochondrial coenzyme A transmembrane transport namespace: biological_process def: "The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11158296] is_a: GO:0035349 ! coenzyme A transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: vw creation_date: 2014-11-19T12:58:26Z [Term] id: GO:1990560 name: obsolete DNA methyltransferase binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a DNA methyltransferase." [PMID:22880885] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "DNA methyltransferase binding" EXACT [] is_obsolete: true created_by: sl creation_date: 2014-11-19T16:30:28Z [Term] id: GO:1990561 name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion starvation namespace: biological_process def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions." [GOC:al, PMID:10593913] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: al creation_date: 2014-11-25T14:21:55Z [Term] id: GO:1990562 name: syndecan-syntenin-ALIX complex namespace: cellular_component def: "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery." [GOC:bhm, PMID:22660413] comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). synonym: "exosome complex" BROAD [] xref: IntAct:EBI-9985210 xref: IntAct:EBI-9985797 is_a: GO:1990563 ! extracellular exosome complex created_by: bhm creation_date: 2014-11-25T16:30:47Z [Term] id: GO:1990563 name: extracellular exosome complex namespace: cellular_component def: "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome." [GOC:bhm, PMID:22660413] comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). synonym: "exosome complex" EXACT [] synonym: "extracellular vesicular exosome complex" EXACT [GOC:vesicles] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0070062 ! extracellular exosome created_by: bhm creation_date: 2014-11-25T16:35:53Z [Term] id: GO:1990564 name: protein polyufmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain." [PMID:25219498] is_a: GO:0071569 ! protein ufmylation created_by: jl creation_date: 2014-11-26T14:15:36Z [Term] id: GO:1990565 name: HSP90-CDC37 chaperone complex namespace: cellular_component def: "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] comment: An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay). xref: IntAct:EBI-9990131 xref: IntAct:EBI-9990540 is_a: GO:0101031 ! chaperone complex relationship: part_of GO:0005737 ! cytoplasm created_by: bhm creation_date: 2014-11-26T14:22:51Z [Term] id: GO:1990566 name: I(KACh) inward rectifier potassium channel complex namespace: cellular_component def: "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits." [GOC:ame, PMID:9765280] comment: Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence. synonym: "GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED [] synonym: "Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED [] synonym: "muscarinic potassium channel complex" RELATED [] xref: IntAct:EBI-9975539 is_a: GO:1902937 ! inward rectifier potassium channel complex created_by: ame creation_date: 2014-11-26T15:16:14Z [Term] id: GO:1990567 name: DPS complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22." [PMID:24945319] is_a: GO:0008287 ! protein serine/threonine phosphatase complex created_by: al creation_date: 2014-11-27T09:56:18Z [Term] id: GO:1990568 name: obsolete MIS18 complex namespace: cellular_component def: "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly." [GOC:bhm, PMID:25036634] comment: An example of this is MIS18A in human (Q9NYP9) in PMID:25036634 (inferred from physical interaction). synonym: "MIS18 complex" EXACT [] xref: IntAct:EBI-9872194 xref: IntAct:EBI-9873644 is_obsolete: true created_by: bhm creation_date: 2014-11-27T10:52:20Z [Term] id: GO:1990569 name: UDP-N-acetylglucosamine transmembrane transport namespace: biological_process alt_id: GO:0015788 def: "The process in which UDP-N-acetylglucosamine is transported across a membrane." [PMID:10788474] synonym: "UDP-N-acetylglucosamine transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport created_by: vw creation_date: 2014-11-27T11:56:35Z [Term] id: GO:1990570 name: GDP-mannose transmembrane transport namespace: biological_process alt_id: GO:0015784 def: "The process in which GDP-mannose is transported across a membrane." [PMID:9395539] synonym: "GDP-mannose transport" RELATED [] is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport created_by: vw creation_date: 2014-11-27T12:05:09Z [Term] id: GO:1990571 name: meiotic centromere clustering namespace: biological_process def: "The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I." [PMID:10366596, PMID:9009280] synonym: "centromere clustering during meiosis" EXACT [] synonym: "homologous chromosome movement towards spindle pole in meiosis I prometaphase" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072698 ! protein localization to microtubule cytoskeleton is_a: GO:0098653 ! centromere clustering created_by: mah creation_date: 2014-12-02T11:25:37Z [Term] id: GO:1990572 name: TERT-RMRP complex namespace: cellular_component def: "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP)." [GOC:bf, GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19701182] synonym: "telomerase reverse transcriptase:RMRP RNA complex" EXACT [PMID:19701182] is_a: GO:0031379 ! RNA-directed RNA polymerase complex is_a: GO:1990904 ! ribonucleoprotein complex created_by: bf creation_date: 2014-12-02T11:29:12Z [Term] id: GO:1990573 name: potassium ion import across plasma membrane namespace: biological_process alt_id: GO:0010107 def: "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127] synonym: "potassium import" BROAD [] synonym: "potassium ion import" BROAD [] synonym: "potassium ion uptake" BROAD [GOC:dph, GOC:tb] is_a: GO:0071805 ! potassium ion transmembrane transport is_a: GO:0098659 ! inorganic cation import across plasma membrane created_by: vw creation_date: 2014-12-04T09:48:12Z [Term] id: GO:1990574 name: meiotic spindle astral microtubule namespace: cellular_component def: "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [PMID:10366596] is_a: GO:0000235 ! astral microtubule intersection_of: GO:0000235 ! astral microtubule intersection_of: part_of GO:0072687 ! meiotic spindle relationship: part_of GO:0072687 ! meiotic spindle created_by: vw creation_date: 2014-12-04T09:55:09Z [Term] id: GO:1990575 name: mitochondrial L-ornithine transmembrane transport namespace: biological_process alt_id: GO:0000066 def: "The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9237680] synonym: "mitochondrial ornithine transmembrane transport" BROAD [] synonym: "mitochondrial ornithine transport" RELATED [] is_a: GO:1903352 ! L-ornithine transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport created_by: mah creation_date: 2014-12-05T11:29:49Z [Term] id: GO:1990576 name: G protein-coupled glucose receptor activity namespace: molecular_function def: "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:15667320] synonym: "G-protein coupled glucose receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity created_by: al creation_date: 2014-12-08T03:15:12Z [Term] id: GO:1990577 name: C-terminal protein demethylation namespace: biological_process def: "The removal of a methyl group from the C-terminal amino acid of a protein." [PMID:11060018] is_a: GO:0006482 ! protein demethylation created_by: mcc creation_date: 2014-12-08T20:55:17Z [Term] id: GO:1990578 name: perinuclear endoplasmic reticulum membrane namespace: cellular_component def: "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus." [PMID:25454947] synonym: "perinuclear ER membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: part_of GO:0097038 ! perinuclear endoplasmic reticulum relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum created_by: mcc creation_date: 2014-12-09T01:13:01Z [Term] id: GO:1990579 name: peptidyl-serine trans-autophosphorylation namespace: biological_process def: "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:bf, GOC:PARL, PMID:21317875] synonym: "serine autophosphorylation in trans" EXACT [PMID:21317875] synonym: "serine transautophosphorylation" EXACT [PMID:21317875] is_a: GO:0036289 ! peptidyl-serine autophosphorylation is_a: GO:0036290 ! protein trans-autophosphorylation created_by: bf creation_date: 2014-12-09T09:20:08Z [Term] id: GO:1990580 name: regulation of cytoplasmic translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975] is_a: GO:0006449 ! regulation of translational termination is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0002184 ! cytoplasmic translational termination relationship: regulates GO:0002184 ! cytoplasmic translational termination created_by: vw creation_date: 2014-12-10T15:48:55Z [Term] id: GO:1990581 name: obsolete lysosome lysis namespace: biological_process def: "OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause." [PMID:24472, PMID:9538255] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "lysosomal lysis" EXACT [] synonym: "lysosome lysis" EXACT [] is_obsolete: true created_by: sl creation_date: 2014-12-10T18:54:00Z [Term] id: GO:1990582 name: obsolete intracellular membrane-bounded organelle binding namespace: molecular_function def: "OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle." [PMID:16100119, PMID:9538255] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "intracellular membrane-bounded organelle binding" EXACT [] synonym: "intracellular membrane-enclosed organelle binding" EXACT [] is_obsolete: true created_by: sl creation_date: 2014-12-10T19:37:09Z [Term] id: GO:1990583 name: phospholipase D activator activity namespace: molecular_function def: "Increases the activity of the enzyme phospholipase D." [PMID:7972129] is_a: GO:0016004 ! phospholipase activator activity relationship: positively_regulates GO:0004630 ! phospholipase D activity created_by: sl creation_date: 2014-12-10T21:04:46Z [Term] id: GO:1990584 name: cardiac Troponin complex namespace: cellular_component def: "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction." [GOC:ame, PMID:12840750] synonym: "cTnC:cTnI:cTnT" RELATED [] xref: IntAct:EBI-9980814 is_a: GO:0005861 ! troponin complex created_by: ame creation_date: 2014-12-12T16:51:41Z [Term] id: GO:1990585 name: hydroxyproline O-arabinosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+." [EC:2.4.2, PMID:24036508] synonym: "HPAT" EXACT [] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups created_by: tb creation_date: 2014-12-12T18:22:20Z [Term] id: GO:1990586 name: divisome complex namespace: cellular_component def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells." [GOC:bhm, PMID:15165235, PMID:21784946] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030428 ! cell septum created_by: bhm creation_date: 2014-12-15T09:13:38Z [Term] id: GO:1990587 name: FtsQBL complex namespace: cellular_component def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ." [GOC:bhm, PMID:15165235, PMID:21784946] comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). synonym: "FtsB-FtsL-FtsQ complex" EXACT [] xref: IntAct:EBI-9547109 is_a: GO:1990586 ! divisome complex created_by: bhm creation_date: 2014-12-15T09:25:09Z [Term] id: GO:1990588 name: FtsBL complex namespace: cellular_component def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL." [GOC:bhm, PMID:15165235, PMID:21784946] comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). synonym: "FtsB-FtsL complex" EXACT [] xref: IntAct:EBI-9997581 is_a: GO:1990586 ! divisome complex relationship: part_of GO:0005829 ! cytosol relationship: part_of GO:1990587 ! FtsQBL complex created_by: bhm creation_date: 2014-12-15T09:33:00Z [Term] id: GO:1990589 name: ATF4-CREB1 transcription factor complex namespace: cellular_component def: "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976] xref: IntAct:EBI-10043081 xref: IntAct:EBI-10043332 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2014-12-15T14:22:44Z [Term] id: GO:1990590 name: ATF1-ATF4 transcription factor complex namespace: cellular_component def: "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." [GOC:bhm, PMID:12871976] comment: An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction). xref: IntAct:EBI-10043123 xref: IntAct:EBI-10043370 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2014-12-15T14:25:56Z [Term] id: GO:1990591 name: asparagine transmembrane import into vacuole namespace: biological_process def: "The directed movement of asparagine into the vacuole across the vacuolar membrane." [PMID:20388511] is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole is_a: GO:1903713 ! asparagine transmembrane transport created_by: vw creation_date: 2014-12-15T16:33:46Z [Term] id: GO:1990592 name: protein K69-linked ufmylation namespace: biological_process def: "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498] is_a: GO:1990564 ! protein polyufmylation created_by: jl creation_date: 2014-12-15T17:01:23Z [Term] id: GO:1990593 name: nascent polypeptide-associated complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the nascent polypeptide-associated complex, which is a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:25487825] synonym: "NAC binding" EXACT [] synonym: "NACA binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding created_by: mcc creation_date: 2014-12-15T22:20:45Z [Term] id: GO:1990594 name: L-altrarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [PMID:17649980] synonym: "L-talarate dehydratase activity" EXACT [] xref: RHEA:44028 is_a: GO:0016836 ! hydro-lyase activity created_by: jl creation_date: 2014-12-16T14:23:55Z [Term] id: GO:1990595 name: mast cell secretagogue receptor activity namespace: molecular_function def: "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells." [GOC:sp, PMID:25517090] is_a: GO:0004930 ! G protein-coupled receptor activity created_by: sp creation_date: 2014-12-22T10:04:43Z [Term] id: GO:1990596 name: histone H3-K4 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone." [PMID:20299449] is_a: GO:0070932 ! histone H3 deacetylation created_by: al creation_date: 2014-12-23T19:37:15Z [Term] id: GO:1990597 name: AIP1-IRE1 complex namespace: cellular_component def: "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285] synonym: "AIP1-ERN1 complex" RELATED [HGNC:3449] synonym: "IRE1-DAB2IP complex" EXACT [GOC:bf] synonym: "IRE1alpha-AIP1 complex" NARROW [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-01-05T15:14:35Z [Term] id: GO:1990598 name: repair of mitotic mono-orientation defect namespace: biological_process def: "The mitotic cell cycle process where mono-orientation defects are corrected in order to ensure sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. Mono-orientation defects occur when both sister kinetochores are attached to MTs from one spindle pole in mitosis and meiosis II." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536] synonym: "correction of mono-orientation defects" EXACT [] synonym: "correction of syntelic kinetochore attachment, mitotic" EXACT [GOC:vw] synonym: "repair of mitotic mono-orientation defects" EXACT [] is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect created_by: jl creation_date: 2015-01-05T16:54:39Z [Term] id: GO:1990599 name: 3' overhang single-stranded DNA endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555] is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity created_by: al creation_date: 2015-01-06T15:21:28Z [Term] id: GO:1990600 name: single-stranded DNA endodeoxyribonuclease activator activity namespace: molecular_function def: "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity." [PMID:25203555] is_a: GO:0008047 ! enzyme activator activity relationship: part_of GO:0032079 ! positive regulation of endodeoxyribonuclease activity created_by: al creation_date: 2015-01-06T15:35:36Z [Term] id: GO:1990601 name: 5' overhang single-stranded DNA endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555] is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity created_by: al creation_date: 2015-01-06T16:24:39Z [Term] id: GO:1990602 name: obsolete importin alpha-subunit nuclear import complex namespace: cellular_component def: "OBSOLETE. A trimeric protein complex which functions to transport the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14)." [GOC:bhm, PMID:20122403] comment: The reason for obsoletion is that these terms include the substrate of the reaction. synonym: "Cdm-Mago-Tsu complex" NARROW [] synonym: "Importin13-Mago-Tsu complex" NARROW [] xref: IntAct:EBI-9673795 is_obsolete: true created_by: bhm creation_date: 2015-01-09T16:28:54Z [Term] id: GO:1990603 name: dark adaptation namespace: biological_process def: "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, http://www.ncbi.nlm.nih.gov/books/NBK11525/, ISBN:0198506732] comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598 is_a: GO:0071485 ! cellular response to absence of light created_by: hjd creation_date: 2015-01-09T20:35:46Z [Term] id: GO:1990604 name: IRE1-TRAF2-ASK1 complex namespace: cellular_component def: "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344] synonym: "ERN1-TRAF2-ASK1 complex" RELATED [HGNC:3449] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane created_by: bf creation_date: 2015-01-13T15:03:04Z [Term] id: GO:1990605 name: GU repeat RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule containing GU repeats." [PMID:20081200] is_a: GO:0003723 ! RNA binding created_by: al creation_date: 2015-01-13T18:18:01Z [Term] id: GO:1990606 name: membrane scission GTPase motor activity namespace: molecular_function def: "Catalysis of the generation of a 'twisting' activity resulting in the scission of a membrane, coupled to the hydrolysis of a nucleoside triphosphate." [PMID:11242086, PMID:23530241, PMID:24515348] is_a: GO:0061791 ! GTPase motor activity created_by: vw creation_date: 2015-01-19T14:26:50Z [Term] id: GO:1990607 name: obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint namespace: biological_process def: "OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint." [GOC:mtg_cell_cycle, GOC:vw, PMID:1234] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: jl creation_date: 2015-01-19T14:43:34Z [Term] id: GO:1990608 name: mitotic spindle pole body localization to nuclear envelope namespace: biological_process def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope." [PMID:24963130] is_a: GO:0071789 ! spindle pole body localization to nuclear envelope is_a: GO:1903047 ! mitotic cell cycle process created_by: vw creation_date: 2015-01-19T17:12:03Z [Term] id: GO:1990609 name: glutamate-cysteine ligase regulator activity namespace: molecular_function def: "Binds to and modulates the activity of glutamate-cysteine ligase." [PMID:8103521] is_a: GO:0030234 ! enzyme regulator activity created_by: vw creation_date: 2015-01-20T12:51:13Z [Term] id: GO:1990610 name: acetolactate synthase regulator activity namespace: molecular_function def: "Binds to and modulates the activity of acetolactate synthase." [PMID:8972574] is_a: GO:0030234 ! enzyme regulator activity created_by: vw creation_date: 2015-01-20T12:54:43Z [Term] id: GO:1990611 name: regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445] is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress created_by: vw creation_date: 2015-01-20T13:04:14Z [Term] id: GO:1990612 name: Sad1-Kms1 LINC complex namespace: cellular_component def: "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair." [GOC:vw, PMID:24943839, PMID:24947240] is_a: GO:0034993 ! meiotic nuclear membrane microtubule tethering complex is_a: GO:1990391 ! DNA repair complex created_by: jl creation_date: 2015-01-20T13:10:49Z [Term] id: GO:1990613 name: mitochondrial membrane fusion namespace: biological_process def: "The joining of two lipid bilayers that surround the mitochondria." [PMID:12052774] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: vw creation_date: 2015-01-21T06:58:18Z [Term] id: GO:1990615 name: Kelch-containing formin regulatory complex namespace: cellular_component def: "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p." [PMID:24828508] synonym: "Bud14-Kel1-Kel2 complex" NARROW [] synonym: "KFRC complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: mcc creation_date: 2015-01-21T18:48:51Z [Term] id: GO:1990616 name: magnesium ion export from mitochondrion namespace: biological_process def: "The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore." [PMID:25585246] synonym: "magnesium ion efflux from mitochondrion" EXACT [] is_a: GO:0045016 ! mitochondrial magnesium ion transmembrane transport created_by: mcc creation_date: 2015-01-21T22:06:42Z [Term] id: GO:1990617 name: CHOP-ATF4 complex namespace: cellular_component def: "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." [GOC:bf, GOC:PARL, PMID:18940792] synonym: "ATF4-CHOP heterodimer" EXACT [PMID:18940792] synonym: "CHOP-ATF4 heterodimer" EXACT [PMID:18940792] synonym: "CHOP-CREB-2 complex" EXACT [PMID:11478948] synonym: "CHOP/ATF4 complex" EXACT [PMID:18940792] synonym: "GADD153-ATF4 complex" EXACT [GOC:bf] is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bf creation_date: 2015-01-22T11:29:51Z [Term] id: GO:1990618 name: obsolete ANPR-A:ANP complex namespace: cellular_component def: "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, PMID:15117952] comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay). synonym: "ANPR-A:ANP complex" EXACT [] xref: IntAct:EBI-10093340 is_obsolete: true created_by: ame creation_date: 2015-01-23T15:17:47Z [Term] id: GO:1990619 name: histone H3-K9 deacetylation namespace: biological_process def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone." [PMID:25002536] is_a: GO:0070932 ! histone H3 deacetylation created_by: al creation_date: 2015-01-23T17:27:16Z [Term] id: GO:1990620 name: ANPR-A receptor complex namespace: cellular_component def: "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, PMID:15117952] comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay). synonym: "NPR1 receptor complex" RELATED [] xref: IntAct:EBI-10093340 is_a: GO:0043235 ! receptor complex created_by: ame creation_date: 2015-01-28T16:03:22Z [Term] id: GO:1990621 name: ESCRT IV complex namespace: cellular_component def: "An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:bhm, GOC:ha, PMID:20653365, PMID:20696398, PMID:21925211, PMID:24456136, PMID:25164817, PMID:26775243] synonym: "ESCRT-IV" EXACT [] synonym: "vacuolar protein sorting-associated complex" RELATED [] synonym: "Vps4 complex" RELATED [] synonym: "Vps4-Vta1 complex" NARROW [] synonym: "VPS4A-VPS4B" NARROW [] synonym: "VPS4A/B complex" NARROW [] synonym: "Vta1-Vps4 complex" RELATED [] xref: IntAct:EBI-11565638 is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex is_a: GO:1904949 ! ATPase complex relationship: part_of GO:0010008 ! endosome membrane created_by: pr creation_date: 2015-01-29T10:02:30Z [Term] id: GO:1990622 name: CHOP-ATF3 complex namespace: cellular_component def: "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660] synonym: "ATF3-CHOP complex" EXACT [GOC:bf] synonym: "CHOP-ATF3 heterodimer" EXACT [GOC:bf] synonym: "CHOP-ATF3 heterodimeric complex" EXACT [GOC:bf] synonym: "GADD153-ATF3 complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-01-29T16:43:19Z [Term] id: GO:1990623 name: Herring body namespace: cellular_component def: "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively." [http://en.wikipedia.org/wiki/Herring_bodies, ISBN:0199652473] synonym: "neurosecretory body" EXACT [] is_a: GO:0043679 ! axon terminus created_by: cynthia.smith creation_date: 2015-01-29T21:11:54Z [Term] id: GO:1990624 name: guanyl nucleotide exchange factor inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a guanyl nucleotide exchange factor." [GOC:vw, PMID:25635048] is_a: GO:0030234 ! enzyme regulator activity created_by: vw creation_date: 2015-01-31T15:17:01Z [Term] id: GO:1990625 name: negative regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress is_a: GO:2000766 ! negative regulation of cytoplasmic translation created_by: vw creation_date: 2015-01-31T21:25:56Z [Term] id: GO:1990626 name: mitochondrial outer membrane fusion namespace: biological_process def: "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:21385840] is_a: GO:0007008 ! outer mitochondrial membrane organization is_a: GO:1990613 ! mitochondrial membrane fusion created_by: vw creation_date: 2015-02-02T11:32:17Z [Term] id: GO:1990627 name: mitochondrial inner membrane fusion namespace: biological_process def: "The membrane organization process that joins two mitochondrial inner membranes to form a single membrane." [GOC:vw, PMID:17055438] is_a: GO:0007007 ! inner mitochondrial membrane organization is_a: GO:1990613 ! mitochondrial membrane fusion created_by: vw creation_date: 2015-02-02T11:37:56Z [Term] id: GO:1990628 name: obsolete Sigma-E factor negative regulation complex namespace: cellular_component def: "OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell." [GOC:bhm, PMID:20190044] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "RseA-RseB-RpoE complex" RELATED [] synonym: "Sigma-E factor negative regulation complex" EXACT [] xref: IntAct:EBI-9019066 is_obsolete: true created_by: bhm creation_date: 2015-02-04T15:38:37Z [Term] id: GO:1990629 name: phospholamban complex namespace: cellular_component def: "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels." [GOC:ame, PMID:16043693] comment: An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay). synonym: "cardiac phospholamban complex" EXACT [] synonym: "cardiac PLB complex" RELATED [] synonym: "cardiac PLN complex" RELATED [] xref: IntAct:EBI-10104734 is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane created_by: ame creation_date: 2015-02-05T14:12:36Z [Term] id: GO:1990630 name: IRE1-RACK1-PP2A complex namespace: cellular_component def: "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773] synonym: "ERN1-RACK1-PP2A complex" RELATED [HGNC:3449] synonym: "IRE1alpha-RACK1-PP2A complex" NARROW [GOC:bf, PMID:20103773] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-02-05T15:37:58Z [Term] id: GO:1990631 name: ErbB-4 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-4/HER4." [GOC:sl, PMID:18523588] synonym: "HER4 receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding created_by: sl creation_date: 2015-02-06T23:28:49Z [Term] id: GO:1990632 name: branching involved in submandibular gland morphogenesis namespace: biological_process def: "The process in which the branching structure of the submandibular gland is generated and organized." [PMID:15063181, PMID:20890964] synonym: "submandibular gland branching morphogenesis" EXACT [PMID:20890964] synonym: "submandibular gland ductal branching" EXACT [PMID:20890964] is_a: GO:0060445 ! branching involved in salivary gland morphogenesis created_by: cynthia.smith creation_date: 2015-02-10T14:40:01Z [Term] id: GO:1990633 name: mutator focus namespace: cellular_component def: "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules." [GOC:kmv, PMID:22713602, PMID:25635455] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule relationship: part_of GO:0048471 ! perinuclear region of cytoplasm created_by: kmv creation_date: 2015-02-10T20:24:02Z [Term] id: GO:1990634 name: protein phosphatase 5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 5." [PMID:8943293] synonym: "protein phosphatase T binding" EXACT [] is_a: GO:0019903 ! protein phosphatase binding created_by: sl creation_date: 2015-02-10T21:30:41Z [Term] id: GO:1990635 name: proximal dendrite namespace: cellular_component def: "The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:16899232] is_a: GO:0030425 ! dendrite created_by: sl creation_date: 2015-02-10T22:57:16Z [Term] id: GO:1990636 name: reproductive senescence namespace: biological_process def: "A natural reduction in reproductive capacity with aging, often taking the form of a switch from regular reproductive cycles to irregular and infrequent ones." [PMID:24914937, PMID:25523082] is_a: GO:0010259 ! multicellular organism aging created_by: sl creation_date: 2015-02-10T23:17:56Z [Term] id: GO:1990637 name: response to prolactin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation." [PMID:7760850] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-02-10T23:47:11Z [Term] id: GO:1990638 name: response to granulocyte colony-stimulating factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469] synonym: "response to G-CSF" EXACT [] is_a: GO:0034097 ! response to cytokine created_by: sl creation_date: 2015-02-11T00:02:33Z [Term] id: GO:1990639 name: obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [PMID:11348594] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "inositol-3,4,5-trisphosphate 5-phosphatase activity" EXACT [] is_obsolete: true created_by: al creation_date: 2015-02-11T15:58:56Z [Term] id: GO:1990640 name: inositol-2,4,5-triphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate." [PMID:15316017] is_a: GO:0046030 ! inositol trisphosphate phosphatase activity created_by: al creation_date: 2015-02-11T18:20:40Z [Term] id: GO:1990641 name: response to iron ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." [PMID:16208485] is_a: GO:0042594 ! response to starvation created_by: sl creation_date: 2015-02-11T18:43:28Z [Term] id: GO:1990642 name: obsolete response to castration namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads." [PMID:11255226] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to castration" EXACT [] is_obsolete: true created_by: sl creation_date: 2015-02-11T18:53:04Z [Term] id: GO:1990643 name: cellular response to granulocyte colony-stimulating factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:1990638 ! response to granulocyte colony-stimulating factor created_by: sl creation_date: 2015-02-11T19:22:44Z [Term] id: GO:1990644 name: microtubule site clamp namespace: molecular_function def: "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore." [PMID:20723757] is_a: GO:0030674 ! protein binding, bridging created_by: vw creation_date: 2015-02-13T15:50:13Z [Term] id: GO:1990645 name: obsolete phosphorylase dephosphorylation namespace: biological_process def: "OBSOLETE. The modification of phosphorylases by removal of phosphate groups." [PMID:8602837] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "phosphorylase dephosphorylation" EXACT [] is_obsolete: true created_by: sl creation_date: 2015-02-18T16:39:50Z [Term] id: GO:1990646 name: cellular response to prolactin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus." [PMID:7760850] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1990637 ! response to prolactin created_by: sl creation_date: 2015-02-18T16:53:11Z [Term] id: GO:1990647 name: C/EBP complex namespace: cellular_component def: "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] comment: An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay). synonym: "C/EBP homodimer complex" EXACT [] synonym: "C/EBP transcription factor complex" EXACT [] synonym: "C/EBPalpha complex" NARROW [] synonym: "C/EBPalpha homodimer complex" NARROW [] synonym: "C/EBPbeta complex" NARROW [] synonym: "C/EBPbeta homodimer complex" NARROW [] xref: IntAct:EBI-10637780 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2015-02-19T11:00:09Z [Term] id: GO:1990648 name: inositol-4,5,6-triphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate." [GOC:al, PMID:15316017] is_a: GO:0046030 ! inositol trisphosphate phosphatase activity created_by: al creation_date: 2015-02-23T11:10:51Z [Term] id: GO:1990649 name: inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate." [GOC:al, PMID:15316017] is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: al creation_date: 2015-02-23T11:12:10Z [Term] id: GO:1990650 name: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." [GOC:al, PMID:15316017] is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: al creation_date: 2015-02-23T11:14:17Z [Term] id: GO:1990651 name: inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate." [GOC:al, PMID:15316017] is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity created_by: al creation_date: 2015-02-23T11:17:19Z [Term] id: GO:1990652 name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [PMID:23695302] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [] is_obsolete: true created_by: al creation_date: 2015-02-23T11:25:51Z [Term] id: GO:1990653 name: obsolete monounsaturated fatty acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids." [GOC:hjd, PMID:16443825] comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. is_obsolete: true created_by: hjd creation_date: 2015-02-23T18:59:15Z [Term] id: GO:1990654 name: sebum secreting cell proliferation namespace: biological_process def: "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083] synonym: "sebocyte proliferation" RELATED [GOC:dph] is_a: GO:0008283 ! cell population proliferation created_by: hjd creation_date: 2015-02-23T19:43:49Z [Term] id: GO:1990655 name: 4 iron, 3 sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria." [GOC:am, PMID:23267108] synonym: "4Fe-3S cluster binding" RELATED [] is_a: GO:0051536 ! iron-sulfur cluster binding created_by: pr creation_date: 2015-02-24T17:07:23Z [Term] id: GO:1990656 name: t-SNARE clustering namespace: biological_process def: "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies." [PMID:22528485] is_a: GO:0072657 ! protein localization to membrane created_by: sl creation_date: 2015-02-25T00:18:33Z [Term] id: GO:1990657 name: iNOS-S100A8/A9 complex namespace: cellular_component def: "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine." [GOC:bhm, PMID:25417112] comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay). xref: IntAct:EBI-10105915 xref: IntAct:EBI-10106087 is_a: GO:1903958 ! nitric-oxide synthase complex is_a: GO:1990658 ! transnitrosylase complex created_by: bhm creation_date: 2015-02-25T11:00:49Z [Term] id: GO:1990658 name: transnitrosylase complex namespace: cellular_component def: "A transferase complex which is capable of transferring nitrogenous groups from one component to another." [GOC:bhm, PMID:25417112] comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). synonym: "transferase complex, transferring nitrogenous groups" EXACT [] is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005737 ! cytoplasm created_by: bhm creation_date: 2015-02-25T11:17:17Z [Term] id: GO:1990659 name: sequestering of manganese ion namespace: biological_process def: "The process of binding or confining manganese ions such that they are separated from other components of a biological system." [GOC:bhm, PMID:25417112] comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). synonym: "manganese ion retention" EXACT [] synonym: "manganese ion sequestering" EXACT [] synonym: "manganese ion sequestration" EXACT [] synonym: "manganese ion storage" EXACT [] synonym: "retention of manganese ion" EXACT [] synonym: "sequestration of manganese ion" EXACT [] synonym: "storage of manganese ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0030026 ! cellular manganese ion homeostasis created_by: bhm creation_date: 2015-02-25T11:41:12Z [Term] id: GO:1990660 name: calprotectin complex namespace: cellular_component def: "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). synonym: "calprotectin heterodimer" NARROW [] xref: IntAct:EBI-10098135 xref: IntAct:EBI-10098681 xref: IntAct:EBI-10098713 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2015-02-25T14:03:17Z [Term] id: GO:1990661 name: S100A8 complex namespace: cellular_component def: "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4)." [GOC:bhm, PMID:25417112] comment: An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay). synonym: "S100A8 homodimer" EXACT [] xref: IntAct:EBI-10098921 xref: IntAct:EBI-10099454 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2015-02-25T15:33:32Z [Term] id: GO:1990662 name: S100A9 complex namespace: cellular_component def: "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility." [GOC:bhm, PMID:15642721] comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay). synonym: "S100A9 homodimer" EXACT [] xref: IntAct:EBI-10099500 xref: IntAct:EBI-10099571 is_a: GO:1902495 ! transmembrane transporter complex created_by: bhm creation_date: 2015-02-25T15:55:48Z [Term] id: GO:1990663 name: dihydroorotate dehydrogenase (fumarate) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [PMID:1409592] xref: EC:1.3.98.1 is_a: GO:0004152 ! dihydroorotate dehydrogenase activity created_by: al creation_date: 2015-02-26T15:47:30Z [Term] id: GO:1990664 name: Nkx-2.5 complex namespace: cellular_component def: "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes." [GOC:ame, PMID:22849347] comment: An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay). synonym: "Nkx-2.5 homodimer complex" NARROW [] synonym: "NKX.2-5 homodimer complex" RELATED [] synonym: "NKX2.5 complex" RELATED [] synonym: "NKX2E homodimer complex" RELATED [] xref: IntAct:EBI-10636829 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: ame creation_date: 2015-02-27T12:22:06Z [Term] id: GO:1990665 name: AnxA2-p11 complex namespace: cellular_component def: "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10)." [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454] synonym: "(A2.p11)2 complex" EXACT [PMID:23483454] synonym: "(p11)2.(AnxA2)2 complex" EXACT [PMID:18799458] synonym: "Annexin A2 tetramer" RELATED [PMID:23483454] synonym: "Annexin A2-p11 complex" EXACT [GOC:bf] synonym: "AnxA2.p11 complex" EXACT [PMID:18799458] synonym: "AnxA2:S100A10 heterotetramer" EXACT [PMID:23483454] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-03-02T10:07:42Z [Term] id: GO:1990666 name: PCSK9-LDLR complex namespace: cellular_component def: "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway." [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079] synonym: "PCSK9.LDLR complex" EXACT [PMID:18799458] synonym: "PCSK9/LDL-R complex" EXACT [PMID:24440079] synonym: "PCSK9:EGF-A complex" RELATED [PMID:18250299] synonym: "PCSK9:low-density lipoprotein receptor complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-03-02T10:19:15Z [Term] id: GO:1990667 name: PCSK9-AnxA2 complex namespace: cellular_component def: "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2)." [GOC:BHF, GOC:nc, PMID:22848640] synonym: "PCSK9-Annexin A2 complex" EXACT [GOC:bf] synonym: "PCSK9.AnxA2 complex" EXACT [PMID:18799458] synonym: "PCSK9:ANXA2 complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-03-02T10:33:09Z [Term] id: GO:1990668 name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] synonym: "vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane" EXACT [] synonym: "vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] synonym: "vesicle fusion with ERGIC membrane" EXACT [] is_a: GO:0006906 ! vesicle fusion created_by: bhm creation_date: 2015-03-02T11:17:32Z [Term] id: GO:1990669 name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane" EXACT [] synonym: "ER-Golgi intermediate compartment derived vesicle fusion with ER membrane" EXACT [] is_a: GO:0048279 ! vesicle fusion with endoplasmic reticulum relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum created_by: bhm creation_date: 2015-03-02T11:21:43Z [Term] id: GO:1990670 name: vesicle fusion with Golgi cis cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] is_a: GO:0006906 ! vesicle fusion created_by: bhm creation_date: 2015-03-02T11:25:19Z [Term] id: GO:1990671 name: vesicle fusion with Golgi medial cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] is_a: GO:0048280 ! vesicle fusion with Golgi apparatus created_by: bhm creation_date: 2015-03-02T11:31:01Z [Term] id: GO:1990672 name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] is_a: GO:0048210 ! Golgi vesicle fusion to target membrane is_a: GO:0048280 ! vesicle fusion with Golgi apparatus relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport created_by: bhm creation_date: 2015-03-02T11:34:39Z [Term] id: GO:1990673 name: intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane namespace: cellular_component def: "The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] is_a: GO:0031300 ! intrinsic component of organelle membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane relationship: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane created_by: bhm creation_date: 2015-03-02T11:44:46Z [Term] id: GO:1990674 name: Golgi cis cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "cis-Golgi cisterna membrane" EXACT [] is_a: GO:0032580 ! Golgi cisterna membrane relationship: part_of GO:0000137 ! Golgi cis cisterna created_by: bhm creation_date: 2015-03-02T11:48:00Z [Term] id: GO:1990675 name: Golgi medial cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "medial-Golgi cisterna membrane" EXACT [] is_a: GO:0032580 ! Golgi cisterna membrane relationship: part_of GO:0005797 ! Golgi medial cisterna created_by: bhm creation_date: 2015-03-02T11:50:29Z [Term] id: GO:1990676 name: Golgi trans cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "trans-Golgi cisterna membrane" EXACT [] is_a: GO:0032580 ! Golgi cisterna membrane relationship: part_of GO:0000138 ! Golgi trans cisterna created_by: bhm creation_date: 2015-03-02T11:53:35Z [Term] id: GO:1990677 name: mitochondrial inner membrane assembly complex namespace: cellular_component def: "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion." [GOC:bhm, PMID:24942160] comment: An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.). synonym: "INAC complex" EXACT [] synonym: "inner membrane assembly complex" BROAD [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex created_by: bhm creation_date: 2015-03-02T13:14:52Z [Term] id: GO:1990678 name: histone H4-K16 deacetylation namespace: biological_process def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone." [PMID:17446861] is_a: GO:0070933 ! histone H4 deacetylation created_by: al creation_date: 2015-03-02T15:25:56Z [Term] id: GO:1990679 name: histone H4-K12 deacetylation namespace: biological_process def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone." [PMID:17446861] is_a: GO:0070933 ! histone H4 deacetylation created_by: al creation_date: 2015-03-02T15:40:44Z [Term] id: GO:1990680 name: response to melanocyte-stimulating hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates." [PMID:17036007] synonym: "response to MSH" EXACT [] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-03-02T20:49:46Z [Term] id: GO:1990682 name: CSF1-CSF1R complex namespace: cellular_component def: "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand." [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797] synonym: "CSF1:C-FMS complex" EXACT [HGNC:2432, HGNC:2433] synonym: "M-CSF:C-FMS complex" RELATED [GOC:nc] synonym: "M-CSF:CSF1R complex" RELATED [HGNC:2432, HGNC:2433] synonym: "M-CSF:FMS complex" EXACT [PMID:19017797] synonym: "macrophage colony-stimulating factor:receptor complex" EXACT [GOC:bf] is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-03-10T12:23:03Z [Term] id: GO:1990683 name: DNA double-strand break attachment to nuclear envelope namespace: biological_process def: "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs." [PMID:24943839] is_a: GO:0097240 ! chromosome attachment to the nuclear envelope created_by: vw creation_date: 2015-03-10T16:36:21Z [Term] id: GO:1990684 name: protein-lipid-RNA complex namespace: cellular_component def: "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634] comment: Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. synonym: "miRNA-lipoprotein complex" RELATED [] is_a: GO:0032991 ! protein-containing complex created_by: pr creation_date: 2015-03-11T14:24:33Z [Term] id: GO:1990685 name: HDL-containing protein-lipid-RNA complex namespace: cellular_component def: "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:23559634] comment: Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs. is_a: GO:1990684 ! protein-lipid-RNA complex created_by: pr creation_date: 2015-03-11T14:56:52Z [Term] id: GO:1990686 name: LDL-containing protein-lipid-RNA complex namespace: cellular_component def: "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:23559634] comment: Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. is_a: GO:1990684 ! protein-lipid-RNA complex created_by: pr creation_date: 2015-03-11T15:11:34Z [Term] id: GO:1990687 name: endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] synonym: "ER-derived vesicle fusion with ERGIC membrane" EXACT [] is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: bhm creation_date: 2015-03-12T09:31:45Z [Term] id: GO:1990688 name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "Golgi vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] synonym: "Golgi vesicle fusion with ERGIC membrane" EXACT [] is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum created_by: bhm creation_date: 2015-03-12T09:34:21Z [Term] id: GO:1990689 name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] synonym: "ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] synonym: "ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane" EXACT [] synonym: "ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] synonym: "ERGIC-derived vesicle fusion with Golgi cis cisterna membrane" EXACT [] is_a: GO:0048280 ! vesicle fusion with Golgi apparatus is_a: GO:1990670 ! vesicle fusion with Golgi cis cisterna membrane relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport created_by: bhm creation_date: 2015-03-12T09:41:48Z [Term] id: GO:1990690 name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] is_a: GO:0048210 ! Golgi vesicle fusion to target membrane is_a: GO:0048280 ! vesicle fusion with Golgi apparatus relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi created_by: bhm creation_date: 2015-03-12T09:47:03Z [Term] id: GO:1990691 name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT [] is_a: GO:0048210 ! Golgi vesicle fusion to target membrane is_a: GO:0048280 ! vesicle fusion with Golgi apparatus relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport created_by: bhm creation_date: 2015-03-12T09:51:01Z [Term] id: GO:1990692 name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane namespace: biological_process def: "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT [] is_a: GO:0048210 ! Golgi vesicle fusion to target membrane is_a: GO:0048280 ! vesicle fusion with Golgi apparatus relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi created_by: bhm creation_date: 2015-03-12T09:54:02Z [Term] id: GO:1990693 name: intrinsic component of Golgi cis cisterna membrane namespace: cellular_component def: "The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "intrinsic component of cis-Golgi cisterna membrane" EXACT [] is_a: GO:0031228 ! intrinsic component of Golgi membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:1990674 ! Golgi cis cisterna membrane relationship: part_of GO:1990674 ! Golgi cis cisterna membrane created_by: bhm creation_date: 2015-03-12T10:24:07Z [Term] id: GO:1990694 name: intrinsic component of Golgi medial cisterna membrane namespace: cellular_component def: "The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "intrinsic component of medial-Golgi cisterna membrane" EXACT [] is_a: GO:0031228 ! intrinsic component of Golgi membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:1990675 ! Golgi medial cisterna membrane relationship: part_of GO:1990675 ! Golgi medial cisterna membrane created_by: bhm creation_date: 2015-03-12T10:29:12Z [Term] id: GO:1990695 name: intrinsic component of Golgi trans cisterna membrane namespace: cellular_component def: "The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "intrinsic component of trans-Golgi cisterna membrane" EXACT [] is_a: GO:0031228 ! intrinsic component of Golgi membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:1990676 ! Golgi trans cisterna membrane relationship: part_of GO:1990676 ! Golgi trans cisterna membrane created_by: bhm creation_date: 2015-03-12T10:36:02Z [Term] id: GO:1990696 name: USH2 complex namespace: cellular_component def: "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7." [GOC:krc, PMID:25406310] synonym: "USH2 quaternary protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: krc creation_date: 2015-03-12T17:29:18Z [Term] id: GO:1990697 name: protein depalmitoleylation namespace: biological_process def: "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein." [PMID:25731175] is_a: GO:0035601 ! protein deacylation is_a: GO:0042159 ! lipoprotein catabolic process created_by: sp creation_date: 2015-03-13T08:55:31Z [Term] id: GO:1990698 name: palmitoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups created_by: sp creation_date: 2015-03-13T08:58:25Z [Term] id: GO:1990699 name: palmitoleyl hydrolase activity namespace: molecular_function def: "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate." [PMID:25731175] is_a: GO:0052689 ! carboxylic ester hydrolase activity created_by: sp creation_date: 2015-03-13T09:00:05Z [Term] id: GO:1990700 name: nucleolar chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] synonym: "establishment or maintenance of nucleolar chromatin architecture" EXACT [] synonym: "nucleolar chromatin organisation" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0006325 ! chromatin organization created_by: mah creation_date: 2015-03-16T12:11:01Z [Term] id: GO:1990701 name: integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane namespace: cellular_component def: "The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "integral component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] synonym: "integral component of ER-Golgi intermediate compartment membrane" EXACT [] synonym: "integral component of ERGIC membrane" EXACT [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:1990673 ! intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane created_by: bhm creation_date: 2015-03-16T15:57:36Z [Term] id: GO:1990702 name: integral component of Golgi cis cisterna membrane namespace: cellular_component def: "The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "integral component of cis-Golgi cisterna membrane" EXACT [] is_a: GO:0030173 ! integral component of Golgi membrane is_a: GO:1990693 ! intrinsic component of Golgi cis cisterna membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:1990674 ! Golgi cis cisterna membrane created_by: bhm creation_date: 2015-03-16T16:03:21Z [Term] id: GO:1990703 name: integral component of Golgi medial cisterna membrane namespace: cellular_component def: "The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "integral component of medial-Golgi cisterna membrane" EXACT [] is_a: GO:0030173 ! integral component of Golgi membrane is_a: GO:1990694 ! intrinsic component of Golgi medial cisterna membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:1990675 ! Golgi medial cisterna membrane created_by: bhm creation_date: 2015-03-16T16:05:25Z [Term] id: GO:1990704 name: integral component of Golgi trans cisterna membrane namespace: cellular_component def: "The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] synonym: "integral component of trans-Golgi cisterna membrane" EXACT [] is_a: GO:0030173 ! integral component of Golgi membrane is_a: GO:1990695 ! intrinsic component of Golgi trans cisterna membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:1990676 ! Golgi trans cisterna membrane created_by: bhm creation_date: 2015-03-16T16:08:07Z [Term] id: GO:1990705 name: cholangiocyte proliferation namespace: biological_process def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010] synonym: "hepatoblast proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation creation_date: 2015-03-16T23:23:50Z [Term] id: GO:1990706 name: MAD1 complex namespace: cellular_component def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)." [GOC:bhm, intAct:EBI-10691224, PMID:22493223, PMID:22898774] synonym: "MAD1 homodimer" EXACT [] xref: IntAct:EBI-10691160 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2015-03-17T15:49:16Z [Term] id: GO:1990707 name: nuclear subtelomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus." [PMID:7660126] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:1990421 ! subtelomeric heterochromatin intersection_of: GO:1990421 ! subtelomeric heterochromatin intersection_of: part_of GO:0005634 ! nucleus created_by: vw creation_date: 2015-03-17T22:29:25Z [Term] id: GO:1990708 name: conditioned place preference namespace: biological_process def: "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821] is_a: GO:0008306 ! associative learning created_by: sl creation_date: 2015-03-18T20:28:59Z [Term] id: GO:1990709 name: presynaptic active zone organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone." [GOC:pr, PMID:16865347, PMID:17068967] synonym: "presynaptic active zone organisation" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0050808 ! synapse organization created_by: pr creation_date: 2015-03-20T10:16:24Z [Term] id: GO:1990710 name: MutS complex namespace: cellular_component def: "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations." [GOC:bhm, PMID:21666597] comment: An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction). synonym: "MutS mismatch repair complex" EXACT [] xref: IntAct:EBI-10705937 is_a: GO:0032300 ! mismatch repair complex is_a: GO:1904949 ! ATPase complex created_by: bhm creation_date: 2015-03-25T11:42:56Z [Term] id: GO:1990711 name: Beta-catenin-ICAT complex namespace: cellular_component def: "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex." [GOC:bhm, PMID:12408824] comment: An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction). synonym: "CTNNB1-CTNNBIP1 complex" EXACT [] xref: IntAct:EBI-10691252 xref: IntAct:EBI-10705284 is_a: GO:0090568 ! nuclear transcriptional repressor complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bhm creation_date: 2015-03-25T21:08:11Z [Term] id: GO:1990712 name: HFE-transferrin receptor complex namespace: cellular_component def: "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription." [GOC:BHF, GOC:kom, PMID:25147378] is_a: GO:0098802 ! plasma membrane signaling receptor complex created_by: pr creation_date: 2015-03-26T13:03:27Z [Term] id: GO:1990713 name: survivin complex namespace: cellular_component def: "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, PMID:10949038] comment: An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction). synonym: "Baculoviral IAP repeat-containing protein 5 complex" EXACT [] synonym: "survivin homodimer complex" NARROW [] xref: IntAct:EBI-10714791 xref: IntAct:EBI-10727115 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005654 ! nucleoplasm created_by: bhm creation_date: 2015-03-26T14:21:46Z [Term] id: GO:1990714 name: hydroxyproline O-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone." [PMID:25600942] synonym: "HPGT" EXACT [] is_a: GO:0008378 ! galactosyltransferase activity created_by: tb creation_date: 2015-03-26T23:22:09Z [Term] id: GO:1990715 name: mRNA CDS binding namespace: molecular_function def: "Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule." [GOC:kmv, PMID:25805859, SO:0000316] synonym: "mRNA coding region binding" EXACT [] synonym: "mRNA coding sequence binding" EXACT [] is_a: GO:0003729 ! mRNA binding created_by: kmv creation_date: 2015-03-27T20:59:49Z [Term] id: GO:1990716 name: axonemal central apparatus namespace: cellular_component def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005930 ! axoneme created_by: krc creation_date: 2015-03-27T22:33:23Z [Term] id: GO:1990717 name: axonemal central bridge namespace: cellular_component def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:1990716 ! axonemal central apparatus created_by: krc creation_date: 2015-03-27T22:38:31Z [Term] id: GO:1990718 name: axonemal central pair projection namespace: cellular_component def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:1990716 ! axonemal central apparatus created_by: krc creation_date: 2015-03-27T22:43:01Z [Term] id: GO:1990719 name: C1 axonemal microtubule namespace: cellular_component def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] synonym: "C1 tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: part_of GO:0097540 ! axonemal central pair created_by: krc creation_date: 2015-03-27T22:55:12Z [Term] id: GO:1990720 name: C2 axonemal microtubule namespace: cellular_component def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] synonym: "C2 tubule" BROAD [] is_a: GO:0005879 ! axonemal microtubule relationship: part_of GO:0097540 ! axonemal central pair created_by: krc creation_date: 2015-03-27T22:58:40Z [Term] id: GO:1990721 name: obsolete prostatic acid phosphatase complex namespace: cellular_component def: "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP." [GOC:bhm, PMID:12525165] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "ACPP homodimer complex" NARROW [] synonym: "PAP complex" EXACT [] synonym: "prostatic acid phosphatase complex" EXACT [] xref: IntAct:EBI-10758257 xref: IntAct:EBI-10758292 is_obsolete: true created_by: bhm creation_date: 2015-04-01T09:43:14Z [Term] id: GO:1990722 name: DAPK1-calmodulin complex namespace: cellular_component def: "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding." [GOC:bhm, PMID:20103772] synonym: "death-associated protein kinase 1 - calmodulin complex" EXACT [] xref: IntAct:EBI-10758257 xref: IntAct:EBI-10758292 is_a: GO:1902554 ! serine/threonine protein kinase complex created_by: bhm creation_date: 2015-04-01T13:05:17Z [Term] id: GO:1990723 name: cytoplasmic periphery of the nuclear pore complex namespace: cellular_component def: "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662] is_a: GO:0048471 ! perinuclear region of cytoplasm created_by: sl creation_date: 2015-04-06T19:26:54Z [Term] id: GO:1990724 name: galectin complex namespace: cellular_component def: "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes." [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940] comment: An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction). synonym: "galectin-1 complex" NARROW [] synonym: "galectin-2 complex" NARROW [] xref: IntAct:EBI-10705755 xref: IntAct:EBI-10705946 xref: IntAct:EBI-10705984 xref: IntAct:EBI-10706026 is_a: GO:0098635 ! protein complex involved in cell-cell adhesion created_by: bhm creation_date: 2015-04-07T15:03:15Z [Term] id: GO:1990725 name: cord factor receptor activity namespace: molecular_function def: "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, PMID:23602766] synonym: "TMD receptor activity" EXACT [] synonym: "trehalose 6,6'-dimycolate receptor activity" EXACT [] xref: Wikipedia:Cord_factor is_a: GO:0038023 ! signaling receptor activity created_by: hjd creation_date: 2015-04-07T20:53:31Z [Term] id: GO:1990726 name: Lsm1-7-Pat1 complex namespace: cellular_component def: "A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202] xref: IntAct:EBI-16419327 is_a: GO:0120114 ! Sm-like protein family complex created_by: pr creation_date: 2015-04-08T09:22:36Z [Term] id: GO:1990727 name: tubulin folding cofactor complex namespace: cellular_component def: "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur." [GOC:vw, PMID:12445400] is_a: GO:0032991 ! protein-containing complex created_by: pr creation_date: 2015-04-08T10:29:43Z [Term] id: GO:1990728 name: mitotic spindle assembly checkpoint MAD1-MAD2 complex namespace: cellular_component def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, PMID:12006501, PMID:22898774] comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction). synonym: "MAD1-MAD2 complex" EXACT [] xref: IntAct:EBI-10691260 xref: IntAct:EBI-10705307 is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990706 ! MAD1 complex relationship: part_of GO:0005737 ! cytoplasm created_by: bhm creation_date: 2015-04-15T10:14:17Z [Term] id: GO:1990729 name: primary miRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within a primary miRNA molecule to produce a primary miRNA molecule with a sequence that differs from that coded genetically." [PMID:25799998] is_a: GO:0009451 ! RNA modification is_a: GO:0031053 ! primary miRNA processing created_by: sp creation_date: 2015-04-16T06:19:22Z [Term] id: GO:1990730 name: VCP-NSFL1C complex namespace: cellular_component def: "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505] synonym: "p97-p47 complex" EXACT [GOC:bf, PMID:12847084] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005737 ! cytoplasm created_by: bf creation_date: 2015-04-20T12:27:35Z [Term] id: GO:1990731 name: UV-damage excision repair, DNA incision namespace: biological_process def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [PMID:10704216] synonym: "alternative excision repair, DNA incision" RELATED [PMID:10704216] synonym: "DNA incision involved in AER" RELATED [PMID:10704216] synonym: "DNA incision involved in alternative excision repair" RELATED [PMID:10704216] synonym: "DNA incision involved in UV-damage excision repair" EXACT [] synonym: "DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [] synonym: "DNA incision involved in UVDE-dependent excision repair" EXACT [] synonym: "DNA incision involved in UVER" EXACT [] synonym: "nucleic acid cleavage involved in UV-damage excision repair" EXACT [] synonym: "UV-damaged DNA endonuclease-dependent excision repair, DNA incision" EXACT [] synonym: "UVDE-dependent excision repair, DNA incision" EXACT [] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0070914 ! UV-damage excision repair created_by: mah creation_date: 2015-04-21T15:09:04Z [Term] id: GO:1990732 name: pyrenoid namespace: cellular_component def: "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation." [GOC:cjm, GOC:pr, PMID:23345319, Wikipedia:Pyrenoid] xref: Wikipedia:Pyrenoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0009536 ! plastid created_by: pr creation_date: 2015-04-24T12:44:52Z [Term] id: GO:1990733 name: titin-telethonin complex namespace: cellular_component def: "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils." [GOC:ame, PMID:16407954] comment: An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay). synonym: "Titin-Tcap complex" RELATED [] xref: IntAct:EBI-10711453 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030018 ! Z disc created_by: ame creation_date: 2015-04-24T14:57:08Z [Term] id: GO:1990734 name: astral microtubule anchoring at mitotic spindle pole body namespace: biological_process def: "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232] is_a: GO:0034631 ! microtubule anchoring at spindle pole body created_by: vw creation_date: 2015-04-28T12:15:18Z [Term] id: GO:1990735 name: gamma-tubulin complex localization to mitotic spindle pole body namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156] synonym: "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body" EXACT [] synonym: "gamma-tubulin complex localisation to mitotic spindle pole body" EXACT [] synonym: "gamma-tubulin complex localization to mitotic SPB" EXACT [] is_a: GO:0033566 ! gamma-tubulin complex localization is_a: GO:1902440 ! protein localization to mitotic spindle pole body created_by: mah creation_date: 2015-04-29T14:40:20Z [Term] id: GO:1990736 name: regulation of vascular smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763] is_a: GO:0051899 ! membrane depolarization created_by: sl creation_date: 2015-04-29T22:33:19Z [Term] id: GO:1990737 name: response to manganese-induced endoplasmic reticulum stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus." [GOC:bf, GOC:PARL, PMID:23934647] synonym: "manganese-induced ER stress response" EXACT [GOC:bf] synonym: "response to manganese-induced ER stress" EXACT [GOC:bf] synonym: "response to Mn-induced ER stress" EXACT [PMID:23934647] is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0062197 ! cellular response to chemical stress is_a: GO:0071287 ! cellular response to manganese ion created_by: bf creation_date: 2015-04-30T13:48:45Z [Term] id: GO:1990738 name: pseudouridine 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631] xref: EC:3.1.3.96 is_a: GO:0016791 ! phosphatase activity created_by: vw creation_date: 2015-05-02T11:05:50Z [Term] id: GO:1990739 name: granulosa cell proliferation namespace: biological_process def: "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759] is_a: GO:0050673 ! epithelial cell proliferation created_by: sl creation_date: 2015-05-06T18:56:04Z [Term] id: GO:1990740 name: obsolete non-selective anion channel activity namespace: molecular_function def: "OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions] comment: This term was made obsolete because it was added in error. synonym: "nonselective anion channel activity" EXACT [] is_obsolete: true created_by: pr creation_date: 2015-05-11T13:25:35Z [Term] id: GO:1990741 name: obsolete non-selective cation channel activity namespace: molecular_function def: "OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions] comment: This term was made obsolete because it was added in error. synonym: "nonselective cation channel activity" EXACT [] is_obsolete: true created_by: pr creation_date: 2015-05-11T13:27:15Z [Term] id: GO:1990742 name: microvesicle namespace: cellular_component def: "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm." [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles] synonym: "ectosome" EXACT [PMID:25683921] synonym: "extracellular microvesicle" EXACT [] synonym: "shedding vesicle" BROAD [] is_a: GO:1903561 ! extracellular vesicle created_by: pr creation_date: 2015-05-13T13:44:52Z [Term] id: GO:1990743 name: protein sialylation namespace: biological_process def: "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein." [PMID:21930713] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0097503 ! sialylation created_by: sl creation_date: 2015-05-14T20:18:28Z [Term] id: GO:1990744 name: primary miRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an primary miRNA molecule." [PMID:25799998] is_a: GO:0001510 ! RNA methylation is_a: GO:1990729 ! primary miRNA modification created_by: sp creation_date: 2015-05-15T05:18:47Z [Term] id: GO:1990745 name: EARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0055037 ! recycling endosome created_by: sp creation_date: 2015-05-15T10:23:25Z [Term] id: GO:1990747 name: pancreatic trypsinogen secretion namespace: biological_process def: "The regulated release of trypsinogen from the cells of the exocrine pancreas." [PMID:12771515] synonym: "pancreatic trypsinogen release" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0030157 ! pancreatic juice secretion created_by: sl creation_date: 2015-05-15T17:41:25Z [Term] id: GO:1990748 name: cellular detoxification namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] is_a: GO:0009987 ! cellular process is_a: GO:0098754 ! detoxification relationship: part_of GO:0097237 ! cellular response to toxic substance created_by: vw creation_date: 2015-05-18T16:17:46Z [Term] id: GO:1990749 name: polynucleotide adenylyltransferase activator activity namespace: molecular_function def: "Increases the activity of the enzyme polynucleotide adenylyltransferase." [GOC:kmv, PMID:19460348] is_a: GO:0008047 ! enzyme activator activity created_by: kmv creation_date: 2015-05-19T15:02:39Z [Term] id: GO:1990750 name: obsolete axon shaft namespace: cellular_component def: "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites." [PMID:11264310, PMID:24312009] comment: This term was made obsolete because it was added in error. synonym: "axonal shaft" EXACT [] is_obsolete: true consider: GO:0044304 created_by: sl creation_date: 2015-05-21T17:46:18Z [Term] id: GO:1990751 name: Schwann cell chemotaxis namespace: biological_process def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995] is_a: GO:0036135 ! Schwann cell migration is_a: GO:0060326 ! cell chemotaxis created_by: sl creation_date: 2015-05-21T19:19:09Z [Term] id: GO:1990752 name: microtubule end namespace: cellular_component def: "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr] comment: This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'. is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005874 ! microtubule created_by: pr creation_date: 2015-05-25T12:50:31Z [Term] id: GO:1990753 name: equatorial cell cortex namespace: cellular_component def: "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression." [GOC:kmv, PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168] is_a: GO:0099738 ! cell cortex region relationship: part_of GO:0032153 ! cell division site created_by: kmv creation_date: 2015-05-27T19:12:41Z [Term] id: GO:1990754 name: obsolete GABAergic neuronal action potential namespace: biological_process def: "OBSOLETE. An action potential that occurs in a GABAergic neuron." [PMID:16921370] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "GABAergic neuronal action potential" EXACT [] is_obsolete: true created_by: pg creation_date: 2015-05-28T08:58:42Z [Term] id: GO:1990755 name: mitotic spindle microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718] synonym: "mitotic spindle microtubule depolymerisation" EXACT [] is_a: GO:0007019 ! microtubule depolymerization created_by: mah creation_date: 2015-05-28T15:42:06Z [Term] id: GO:1990756 name: protein binding, bridging involved in substrate recognition for ubiquitination namespace: molecular_function def: "The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] is_a: GO:0030674 ! protein binding, bridging intersection_of: GO:0030674 ! protein binding, bridging intersection_of: part_of GO:0016567 ! protein ubiquitination relationship: part_of GO:0016567 ! protein ubiquitination created_by: vw creation_date: 2015-06-01T08:35:16Z [Term] id: GO:1990757 name: ubiquitin ligase activator activity namespace: molecular_function alt_id: GO:0061636 def: "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242] synonym: "mitotic anaphase-promoting complex activator activity" NARROW [] is_a: GO:0097027 ! ubiquitin-protein transferase activator activity relationship: part_of GO:1904668 ! positive regulation of ubiquitin protein ligase activity created_by: vw creation_date: 2015-06-01T08:53:04Z [Term] id: GO:1990758 name: mitotic sister chromatid biorientation namespace: biological_process def: "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression." [PMID:15309047, PMID:26258632, PMID:26705896] is_a: GO:0031134 ! sister chromatid biorientation is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0031134 ! sister chromatid biorientation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: has_part GO:0051010 ! microtubule plus-end binding created_by: vw creation_date: 2015-06-02T12:36:17Z [Term] id: GO:1990760 name: osmolarity-sensing cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides." [PMID:18279313] is_a: GO:0005034 ! osmosensor activity is_a: GO:0005261 ! cation channel activity is_a: GO:0022836 ! gated channel activity created_by: sl creation_date: 2015-06-05T21:58:50Z [Term] id: GO:1990761 name: growth cone lamellipodium namespace: cellular_component def: "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments." [GOC:dos, PMID:25598228] is_a: GO:0030027 ! lamellipodium is_a: GO:0043005 ! neuron projection relationship: part_of GO:0030426 ! growth cone created_by: sl creation_date: 2015-06-05T22:31:19Z [Term] id: GO:1990762 name: cytoplasmic alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation." [GOC:vw] is_a: GO:0006419 ! alanyl-tRNA aminoacylation relationship: part_of GO:0002181 ! cytoplasmic translation created_by: vw creation_date: 2015-06-08T15:56:51Z [Term] id: GO:1990763 name: arrestin family protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors." [PMID:23911909] is_a: GO:0005515 ! protein binding created_by: sl creation_date: 2015-06-09T23:29:42Z [Term] id: GO:1990764 name: myofibroblast contraction namespace: biological_process def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast." [PMID:19239477] synonym: "MF contraction" EXACT [] synonym: "MFB contraction" EXACT [] is_a: GO:0070252 ! actin-mediated cell contraction created_by: sl creation_date: 2015-06-09T23:43:09Z [Term] id: GO:1990765 name: colon smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253] is_a: GO:0006939 ! smooth muscle contraction relationship: part_of GO:0014827 ! intestine smooth muscle contraction created_by: sl creation_date: 2015-06-10T18:29:21Z [Term] id: GO:1990767 name: prostaglandin receptor internalization namespace: biological_process def: "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle." [PMID:15937517] is_a: GO:0002031 ! G protein-coupled receptor internalization created_by: sl creation_date: 2015-06-10T19:14:08Z [Term] id: GO:1990768 name: gastric mucosal blood circulation namespace: biological_process def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] synonym: "stomach mucosal blood circulation" EXACT [] is_a: GO:0008015 ! blood circulation created_by: sl creation_date: 2015-06-10T20:11:09Z [Term] id: GO:1990769 name: proximal neuron projection namespace: cellular_component def: "The portion of an axon or dendrite that is close to the neuronal cell body." [PMID:21104189] is_a: GO:0043005 ! neuron projection created_by: sl creation_date: 2015-06-10T20:30:40Z [Term] id: GO:1990770 name: small intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] is_a: GO:0006939 ! smooth muscle contraction relationship: part_of GO:0014827 ! intestine smooth muscle contraction created_by: sl creation_date: 2015-06-11T18:02:33Z [Term] id: GO:1990771 name: clathrin-dependent extracellular exosome endocytosis namespace: biological_process def: "The clathrin-mediated endocytosis of an extracellular exosome." [PMID:24951588] synonym: "clathrin-mediated extracellular exosome endocytosis" EXACT [] synonym: "exosome related" EXACT [] is_a: GO:0051650 ! establishment of vesicle localization is_a: GO:0072583 ! clathrin-dependent endocytosis created_by: sl creation_date: 2015-06-15T17:03:57Z [Term] id: GO:1990772 name: substance P secretion namespace: biological_process def: "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity." [PMID:11278900] is_a: GO:0030072 ! peptide hormone secretion created_by: sl creation_date: 2015-06-15T18:17:30Z [Term] id: GO:1990773 name: matrix metallopeptidase secretion namespace: biological_process def: "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins." [PMID:8679543] synonym: "matrix metalloproteinase secretion" NARROW [] synonym: "MMP secretion" EXACT [] is_a: GO:0009306 ! protein secretion created_by: sl creation_date: 2015-06-15T19:12:06Z [Term] id: GO:1990774 name: tumor necrosis factor secretion namespace: biological_process def: "The regulated release of tumor necrosis factor from a cell. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [PMID:15560120] synonym: "cachectin secretion" EXACT [] synonym: "TNF secretion" EXACT [] synonym: "TNF superfamily, member 2 secretion" EXACT [] synonym: "TNF-alpha secretion" EXACT [] synonym: "Tnfa secretion" EXACT [] synonym: "tumor necrosis factor alpha secretion" EXACT [] synonym: "tumor necrosis factor ligand superfamily member 2 secretion" EXACT [] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032640 ! tumor necrosis factor production created_by: sl creation_date: 2015-06-15T22:59:26Z [Term] id: GO:1990775 name: endothelin secretion namespace: biological_process def: "The regulated release of endothelin from a cell. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120] synonym: "EDN1 secretion" NARROW [] synonym: "EDN2 secretion" NARROW [] synonym: "EDN3 secretion" NARROW [] synonym: "endothelin-1 secretion" NARROW [] synonym: "endothelin-2 secretion" NARROW [] synonym: "endothelin-3 secretion" NARROW [] is_a: GO:0050663 ! cytokine secretion created_by: sl creation_date: 2015-06-15T23:13:18Z [Term] id: GO:1990776 name: response to angiotensin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [PMID:22982863] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-06-16T17:41:17Z [Term] id: GO:1990777 name: lipoprotein particle namespace: cellular_component def: "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles] is_a: GO:0032994 ! protein-lipid complex created_by: pr creation_date: 2015-06-18T08:42:53Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0034613 ! cellular protein localization creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990779 name: glycoprotein Ib-IX-V complex namespace: cellular_component def: "A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation." [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919] comment: An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay). synonym: "CD42" EXACT [] synonym: "GPIb-IX-V complex" EXACT [] synonym: "GPIb-V-IX complex" EXACT [] xref: IntAct:EBI-10727454 xref: IntAct:EBI-10728062 is_a: GO:0090665 ! glycoprotein complex is_a: GO:0098802 ! plasma membrane signaling receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane created_by: bhm creation_date: 2015-06-23T11:22:12Z [Term] id: GO:1990780 name: cytoplasmic side of dendritic spine plasma membrane namespace: cellular_component def: "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine." [PMID:9275233] is_a: GO:0009898 ! cytoplasmic side of plasma membrane relationship: part_of GO:0032591 ! dendritic spine membrane created_by: sl creation_date: 2015-06-23T18:35:39Z [Term] id: GO:1990781 name: response to immobilization stress combined with electrical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile." [PMID:17008368] is_a: GO:0035902 ! response to immobilization stress is_a: GO:0051602 ! response to electrical stimulus created_by: sl creation_date: 2015-06-23T20:30:42Z [Term] id: GO:1990782 name: protein tyrosine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein tyrosine kinase." [PMID:25499537] synonym: "tyrosine kinase binding" EXACT [] is_a: GO:0019901 ! protein kinase binding created_by: sl creation_date: 2015-06-23T20:50:58Z [Term] id: GO:1990783 name: periphagosomal region of cytoplasm namespace: cellular_component def: "Cytoplasm situated near, or occurring around, a phagosome." [PMID:18250451] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005737 ! cytoplasm created_by: sl creation_date: 2015-06-23T21:46:10Z [Term] id: GO:1990784 name: response to dsDNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633] synonym: "response to double-stranded DNA" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901698 ! response to nitrogen compound created_by: sl creation_date: 2015-06-24T17:54:13Z [Term] id: GO:1990785 name: response to water-immersion restraint stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile." [PMID:10882227] synonym: "response to immobilization stress combined with water immersion" EXACT [] is_a: GO:0035902 ! response to immobilization stress created_by: sl creation_date: 2015-06-24T18:27:28Z [Term] id: GO:1990786 name: cellular response to dsDNA namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1990784 ! response to dsDNA created_by: sl creation_date: 2015-06-24T22:48:25Z [Term] id: GO:1990787 name: negative regulation of hh target transcription factor activity namespace: biological_process def: "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling." [GOC:bhm, PMID:24311597] synonym: "negative regulation of hedgehog target transcription factor" EXACT [] xref: IntAct:EBI-10170144 is_a: GO:0045879 ! negative regulation of smoothened signaling pathway is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity created_by: bhm creation_date: 2015-06-26T09:54:29Z [Term] id: GO:1990788 name: GLI-SUFU complex namespace: cellular_component def: "A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, PMID:24311597] comment: An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay). xref: IntAct:EBI-10170144 xref: IntAct:EBI-10828915 xref: IntAct:EBI-10828948 xref: IntAct:EBI-10828976 xref: IntAct:EBI-10828997 xref: IntAct:EBI-10829035 is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005829 ! cytosol created_by: bhm creation_date: 2015-06-26T13:49:47Z [Term] id: GO:1990789 name: thyroid gland epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population." [PMID:17646383] synonym: "Hurthle cell proliferation" NARROW [] synonym: "thyroid follicular cell proliferation" NARROW [] is_a: GO:0050673 ! epithelial cell proliferation relationship: part_of GO:0030878 ! thyroid gland development created_by: sl creation_date: 2015-07-02T18:50:01Z [Term] id: GO:1990790 name: response to glial cell derived neurotrophic factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310] synonym: "response to astrocyte-derived trophic factor" EXACT [] synonym: "response to ATF" EXACT [] synonym: "response to GDNF" EXACT [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0070848 ! response to growth factor created_by: sl creation_date: 2015-07-02T19:47:05Z [Term] id: GO:1990791 name: dorsal root ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150] synonym: "DRG development" EXACT [] is_a: GO:0061548 ! ganglion development created_by: sl creation_date: 2015-07-02T22:09:54Z [Term] id: GO:1990792 name: cellular response to glial cell derived neurotrophic factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310] synonym: "cellular response to astrocyte-derived trophic factor" EXACT [] synonym: "cellular response to ATF" EXACT [] synonym: "cellular response to GDNF" EXACT [] is_a: GO:0071363 ! cellular response to growth factor stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:1990790 ! response to glial cell derived neurotrophic factor created_by: sl creation_date: 2015-07-06T15:27:38Z [Term] id: GO:1990793 name: substance P secretion, neurotransmission namespace: biological_process def: "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter." [PMID:15292051] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:1990772 ! substance P secretion created_by: sl creation_date: 2015-07-09T19:43:36Z [Term] id: GO:1990794 name: basolateral part of cell namespace: cellular_component def: "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells." [PMID:18495799] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0045178 ! basal part of cell relationship: part_of GO:0097574 ! lateral part of cell created_by: sl creation_date: 2015-07-09T20:31:50Z [Term] id: GO:1990795 name: rod bipolar cell terminal bouton namespace: cellular_component def: "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:19883736] is_a: GO:0043195 ! terminal bouton created_by: sl creation_date: 2015-07-09T21:11:53Z [Term] id: GO:1990796 name: photoreceptor cell terminal bouton namespace: cellular_component def: "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light." [PMID:19883736] is_a: GO:0043195 ! terminal bouton created_by: sl creation_date: 2015-07-09T21:33:40Z [Term] id: GO:1990797 name: obsolete cholecystokinin secretion namespace: biological_process def: "OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain." [PMID:2755938] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "CCK secretion" EXACT [] is_obsolete: true created_by: sl creation_date: 2015-07-09T23:14:23Z [Term] id: GO:1990798 name: pancreas regeneration namespace: biological_process def: "The regrowth of a destroyed pancreas." [PMID:1985964] is_a: GO:0031100 ! animal organ regeneration created_by: sl creation_date: 2015-07-10T22:53:53Z [Term] id: GO:1990799 name: mitochondrial tRNA wobble position uridine thiolation namespace: biological_process def: "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579] is_a: GO:0002143 ! tRNA wobble position uridine thiolation is_a: GO:0070899 ! mitochondrial tRNA wobble uridine modification is_a: GO:0070903 ! mitochondrial tRNA thio-modification created_by: vw creation_date: 2015-07-13T08:15:15Z [Term] id: GO:1990800 name: obsolete meiotic APC-fizzy-related complex namespace: cellular_component def: "OBSOLETE. An anaphase promoting complex bound to a \"fizzy-related family\" APC activator that regulates meiotic exit by activating the APC/C to target meiotic cyclins for destruction during meiosis." [PMID:11493649] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2015-07-16T10:37:05Z [Term] id: GO:1990801 name: obsolete protein phosphorylation involved in mitotic spindle assembly namespace: biological_process def: "OBSOLETE. Any protein phosphorylation that is involved in mitotic spindle assembly." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21558801] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term, see discussion in https://github.com/geneontology/go-ontology/issues/14137. synonym: "protein amino acid phosphorylation involved in mitotic spindle assembly" EXACT [] synonym: "protein amino acid phosphorylation involved in spindle assembly involved in mitosis" EXACT [] synonym: "protein phosphorylation involved in spindle assembly involved in mitosis" EXACT [] is_obsolete: true created_by: rb creation_date: 2015-07-16T18:36:05Z [Term] id: GO:1990802 name: obsolete protein phosphorylation involved in DNA double-strand break processing namespace: biological_process def: "OBSOLETE. Any protein phosphorylation that is required for DNA double-strand break processing." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21841787] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term, see discussion in https://github.com/geneontology/go-ontology/issues/14137. synonym: "protein amino acid phosphorylation involved in DNA double-strand break processing" EXACT [] is_obsolete: true created_by: rb creation_date: 2015-07-16T20:43:39Z [Term] id: GO:1990803 name: obsolete protein phosphorylation involved in protein localization to spindle microtubule namespace: biological_process def: "OBSOLETE. Any protein phosphorylation process involved in localizing a protein to the spindle microtubule." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22521784] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term, see discussion in https://github.com/geneontology/go-ontology/issues/14137. synonym: "protein amino acid phosphorylation involved in protein localisation in spindle microtubule" EXACT [] synonym: "protein amino acid phosphorylation involved in protein localisation to spindle microtubule" EXACT [] synonym: "protein amino acid phosphorylation involved in protein localization in spindle microtubule" EXACT [] synonym: "protein amino acid phosphorylation involved in protein localization to spindle microtubule" EXACT [] synonym: "protein phosphorylation involved in protein localisation in spindle microtubule" EXACT [] synonym: "protein phosphorylation involved in protein localisation to spindle microtubule" EXACT [] synonym: "protein phosphorylation involved in protein localization in spindle microtubule" EXACT [] is_obsolete: true created_by: rb creation_date: 2015-07-16T21:09:07Z [Term] id: GO:1990804 name: obsolete protein phosphorylation involved in double-strand break repair via nonhomologous end joining namespace: biological_process def: "OBSOLETE. Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22563681] comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term, see discussion in https://github.com/geneontology/go-ontology/issues/14137. synonym: "protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining" EXACT [] synonym: "protein amino acid phosphorylation involved in NHEJ" EXACT [] synonym: "protein phosphorylation involved in NHEJ" EXACT [] is_obsolete: true created_by: rb creation_date: 2015-07-16T21:54:01Z [Term] id: GO:1990805 name: central cylinder namespace: cellular_component def: "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules." [GOC:kmv, PMID:2428682, PMID:26124290] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0035869 ! ciliary transition zone created_by: kmv creation_date: 2015-07-17T17:48:17Z [Term] id: GO:1990806 name: ligand-gated ion channel signaling pathway namespace: biological_process def: "A series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137] synonym: "ligand-gated ion channel signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction created_by: bhm creation_date: 2015-07-20T12:09:56Z [Term] id: GO:1990807 name: obsolete protein N-acetyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein." [GOC:dph] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: vw creation_date: 2015-07-20T15:19:23Z [Term] id: GO:1990808 name: F-bar domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins." [PMID:20603077] is_a: GO:0019904 ! protein domain specific binding created_by: vw creation_date: 2015-07-21T18:43:00Z [Term] id: GO:1990809 name: endoplasmic reticulum tubular network membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336] is_a: GO:0061024 ! membrane organization is_a: GO:0071786 ! endoplasmic reticulum tubular network organization created_by: vw creation_date: 2015-07-22T16:42:36Z [Term] id: GO:1990810 name: microtubule anchoring at mitotic spindle pole body namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:17486116] is_a: GO:0034631 ! microtubule anchoring at spindle pole body is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis relationship: part_of GO:0090307 ! mitotic spindle assembly created_by: vw creation_date: 2015-07-24T12:52:25Z [Term] id: GO:1990811 name: MWP complex namespace: cellular_component def: "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607, PMID:29021344] synonym: "Msd1-Wdr8-Pkl1 complex" EXACT [GOC:vw] is_a: GO:0032991 ! protein-containing complex created_by: vw creation_date: 2015-07-24T13:34:31Z [Term] id: GO:1990812 name: growth cone filopodium namespace: cellular_component def: "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone." [PMID:25598228] is_a: GO:0030175 ! filopodium is_a: GO:0043005 ! neuron projection relationship: part_of GO:0030426 ! growth cone created_by: sl creation_date: 2015-07-24T22:35:16Z [Term] id: GO:1990813 name: meiotic centromeric cohesion protection namespace: biological_process def: "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions." [PMID:14730319, PMID:25533956] synonym: "protection of centromeric cohesion during meiotic anaphase I" EXACT [] is_a: GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric relationship: part_of GO:0045143 ! homologous chromosome segregation created_by: vw creation_date: 2015-07-28T16:15:31Z [Term] id: GO:1990814 name: DNA/DNA annealing activity namespace: molecular_function def: "A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA." [PMID:25520186] synonym: "DNA reannealing activity" EXACT [] is_a: GO:0097617 ! annealing activity created_by: vw creation_date: 2015-07-29T12:35:03Z [Term] id: GO:1990815 name: obsolete regulation of protein localization to cell division site after cytokinesis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: vw creation_date: 2015-07-29T14:03:34Z [Term] id: GO:1990816 name: vacuole-mitochondrion membrane contact site namespace: cellular_component def: "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles." [PMID:25026035, PMID:25026036] synonym: "vacuole and mitochondria patch" EXACT [] synonym: "vCLAMP" EXACT [] is_a: GO:0044232 ! organelle membrane contact site created_by: mcc creation_date: 2015-07-29T21:06:41Z [Term] id: GO:1990817 name: RNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group." [GOC:vw] is_a: GO:0004652 ! polynucleotide adenylyltransferase activity created_by: vw creation_date: 2015-07-31T09:38:31Z [Term] id: GO:1990818 name: L-arginine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598] is_a: GO:0032974 ! amino acid transmembrane export from vacuole is_a: GO:0046618 ! drug export is_a: GO:1903400 ! L-arginine transmembrane transport created_by: vw creation_date: 2015-08-06T15:06:33Z [Term] id: GO:1990819 name: actin fusion focus namespace: cellular_component def: "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517] is_a: GO:0110165 ! cellular anatomical entity relationship: has_part GO:0005884 ! actin filament relationship: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0043332 ! mating projection tip created_by: al creation_date: 2015-08-10T16:52:15Z [Term] id: GO:1990820 name: response to mitotic DNA integrity checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling." [PMID:7548844] synonym: "response to signal involved in mitotic DNA integrity checkpoint" EXACT [] is_a: GO:0072402 ! response to DNA integrity checkpoint signaling is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling created_by: mah creation_date: 2015-08-14T10:25:46Z [Term] id: GO:1990822 name: basic amino acid transmembrane transport namespace: biological_process def: "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015802 ! basic amino acid transport created_by: vw creation_date: 2015-08-19T07:47:00Z [Term] id: GO:1990823 name: response to leukemia inhibitory factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913] synonym: "response to CDF" EXACT [] synonym: "response to cholinergic differentiation factor" EXACT [] synonym: "response to LIF" EXACT [] is_a: GO:0034097 ! response to cytokine created_by: sl creation_date: 2015-08-19T16:44:21Z [Term] id: GO:1990824 name: obsolete magnesium-dependent protein complex namespace: cellular_component def: "OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex." [PMID:10220587] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-08-19T17:11:43Z [Term] id: GO:1990825 name: sequence-specific mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857] is_a: GO:0003729 ! mRNA binding created_by: sl creation_date: 2015-08-19T17:42:50Z [Term] id: GO:1990826 name: nucleoplasmic periphery of the nuclear pore complex namespace: cellular_component def: "Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex." [PMID:10633080] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005654 ! nucleoplasm created_by: sl creation_date: 2015-08-19T18:26:26Z [Term] id: GO:1990827 name: deaminase binding namespace: molecular_function def: "Interacting selectively and non-covalently with an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)." [PMID:9792439] is_a: GO:0019899 ! enzyme binding created_by: sl creation_date: 2015-08-19T23:48:32Z [Term] id: GO:1990828 name: hepatocyte dedifferentiation namespace: biological_process def: "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:20102719] is_a: GO:0043697 ! cell dedifferentiation created_by: sl creation_date: 2015-08-20T14:14:57Z [Term] id: GO:1990829 name: C-rich single-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with C-rich, single-stranded DNA." [PMID:8127654] synonym: "C-rich ssDNA binding" EXACT [] is_a: GO:0003697 ! single-stranded DNA binding created_by: sl creation_date: 2015-08-20T16:05:12Z [Term] id: GO:1990830 name: cellular response to leukemia inhibitory factor namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913] synonym: "cellular response to CDF" EXACT [] synonym: "cellular response to cholinergic differentiation factor" EXACT [] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:1990823 ! response to leukemia inhibitory factor created_by: sl creation_date: 2015-08-20T19:30:38Z [Term] id: GO:1990831 name: cellular response to carcinoembryonic antigen namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins" [PMID:10202129, PMID:14597422] synonym: "cellular response to pregnancy specific glycoprotein" EXACT [] is_a: GO:1904588 ! cellular response to glycoprotein created_by: sl creation_date: 2015-08-20T19:43:12Z [Term] id: GO:1990832 name: slow axonal transport namespace: biological_process def: "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a \"slow component a\" (SCa) and a \"slow component b\" (SCb) which differ in transport rates and protein composition." [PMID:6378920] is_a: GO:0008088 ! axo-dendritic transport created_by: sl creation_date: 2015-08-21T17:27:32Z [Term] id: GO:1990833 name: clathrin-uncoating ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP." [PMID:6146630, PMID:8363588] is_a: GO:0042623 ! ATPase activity, coupled relationship: part_of GO:0072318 ! clathrin coat disassembly created_by: sl creation_date: 2015-08-21T18:01:42Z [Term] id: GO:1990834 name: response to odorant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell." [PMID:11268007] is_a: GO:0042221 ! response to chemical created_by: sl creation_date: 2015-08-21T18:51:52Z [Term] id: GO:1990835 name: obsolete insulin-like growth factor production namespace: biological_process def: "OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:21993393] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "IGF production" RELATED [] is_obsolete: true created_by: sl creation_date: 2015-08-24T16:30:53Z [Term] id: GO:1990836 name: lysosomal matrix namespace: cellular_component def: "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome." [PMID:9395337] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043202 ! lysosomal lumen created_by: sl creation_date: 2015-08-25T17:04:12Z [Term] id: GO:1990837 name: sequence-specific double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] synonym: "sequence-specific dsDNA binding" EXACT [] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0043565 ! sequence-specific DNA binding created_by: sl creation_date: 2015-08-25T17:30:06Z [Term] id: GO:1990838 name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends namespace: molecular_function def: "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)." [PMID:23022480] is_a: GO:0000175 ! 3'-5'-exoribonuclease activity created_by: al creation_date: 2015-08-26T10:24:51Z [Term] id: GO:1990839 name: response to endothelin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-08-27T19:37:52Z [Term] id: GO:1990840 name: response to lectin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444] comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. is_a: GO:0009607 ! response to biotic stimulus created_by: sl creation_date: 2015-08-27T20:02:21Z [Term] id: GO:1990841 name: promoter-specific chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] is_a: GO:0003682 ! chromatin binding created_by: sl creation_date: 2015-08-28T14:48:29Z [Term] id: GO:1990842 name: obsolete response to prenatal stress namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy." [PMID:22738222] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to PNS" EXACT [] is_obsolete: true created_by: sl creation_date: 2015-08-31T15:15:29Z [Term] id: GO:1990843 name: subsarcolemmal mitochondrion namespace: cellular_component def: "A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174] synonym: "SS mitochondrion" EXACT [] synonym: "SSM" EXACT [] is_a: GO:0005739 ! mitochondrion created_by: sl creation_date: 2015-08-31T16:05:14Z [Term] id: GO:1990844 name: interfibrillar mitochondrion namespace: cellular_component def: "A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174] synonym: "IFM" EXACT [] synonym: "IMF mitochondrion" EXACT [] synonym: "intermyofibrillar mitochondrion" EXACT [] is_a: GO:0005739 ! mitochondrion created_by: sl creation_date: 2015-08-31T16:26:44Z [Term] id: GO:1990845 name: adaptive thermogenesis namespace: biological_process def: "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363] is_a: GO:0008152 ! metabolic process created_by: sl creation_date: 2015-08-31T18:19:49Z [Term] id: GO:1990846 name: ribonucleoside-diphosphate reductase inhibitor activity namespace: molecular_function def: "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase." [PMID:16317005] is_a: GO:0004857 ! enzyme inhibitor activity created_by: vw creation_date: 2015-09-04T18:13:15Z [Term] id: GO:1990847 name: peptide pheromone transmembrane export involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [PMID:9236781] is_a: GO:0071833 ! peptide pheromone export involved in positive regulation of conjugation with cellular fusion is_a: GO:0090539 ! peptide pheromone export by transmembrane transport created_by: al creation_date: 2015-09-08T15:23:26Z [Term] id: GO:1990848 name: obsolete Positive regulation of removal of reactive oxygen species namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell." [PMID:24118096] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2015-09-09T11:59:57Z [Term] id: GO:1990849 name: maintenance of vacuolar location namespace: biological_process def: "Any process in which the vacuole is maintained in a specific location within a cell and prevented from moving elsewhere." [PMID:26283797] synonym: "maintenance of vacuolar localization" EXACT [] synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization is_a: GO:0051657 ! maintenance of organelle location created_by: mcc creation_date: 2015-09-10T08:16:02Z [Term] id: GO:1990850 name: H-gal-GP complex namespace: cellular_component def: "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus." [PMID:11166393] synonym: "galactose-containing glycoprotein complex" NARROW [] synonym: "Haemonchus galactose-containing glycoprotein complex" EXACT [] is_a: GO:0098796 ! membrane protein complex is_a: GO:1905368 ! peptidase complex created_by: jl creation_date: 2015-09-10T16:40:39Z [Term] id: GO:1990851 name: Wnt-Frizzled-LRP5/6 complex namespace: cellular_component def: "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6." [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360] comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form. synonym: "Frizzled-LRP5/6 complex" RELATED [GOC:bf] synonym: "Fz/Wnt/LRP6 complex" NARROW [PMID:20093360] synonym: "Wnt receptor complex" BROAD [GOC:bf] synonym: "WNT-FZD-LRP5 complex" NARROW [PMID:23209147] synonym: "Wnt-FZD-LRP5/6 trimeric complex" EXACT [PMID:23209147] synonym: "WNT-FZD-LRP6 complex" NARROW [PMID:23209147] synonym: "Wnt-induced Frizzled-LRP5/6 complex" RELATED [GOC:bf] synonym: "Wnt.Fz.LRP ternary complex" EXACT [PMID:20093360] is_a: GO:0098797 ! plasma membrane protein complex created_by: bf creation_date: 2015-09-14T15:59:54Z [Term] id: GO:1990852 name: protein transport along microtubule to spindle pole body namespace: biological_process def: "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins." [PMID:25987607] is_a: GO:0071989 ! establishment of protein localization to spindle pole body is_a: GO:0098840 ! protein transport along microtubule created_by: vw creation_date: 2015-09-15T11:09:54Z [Term] id: GO:1990853 name: histone H2A SQE motif phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone." [DOI:10.1038/35052000, PMID:15226425] is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:1990164 ! histone H2A phosphorylation created_by: al creation_date: 2015-09-15T15:18:02Z [Term] id: GO:1990854 name: vacuole-ER tethering namespace: biological_process def: "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:26283797] synonym: "vacuole-endoplasmic reticulum attachment" EXACT [] synonym: "vacuole-endoplasmic reticulum tethering" EXACT [] synonym: "vacuole-ER attachment" EXACT [] is_a: GO:0016043 ! cellular component organization is_a: GO:0051685 ! maintenance of ER location is_a: GO:0140056 ! organelle localization by membrane tethering is_a: GO:1990849 ! maintenance of vacuolar location created_by: mcc creation_date: 2015-09-15T18:50:04Z [Term] id: GO:1990855 name: obsolete myo-inositol import across plasma membrane namespace: biological_process def: "OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane." [PMID:9560432] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2015-09-17T16:52:32Z [Term] id: GO:1990856 name: methionyl-initiator methionine tRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with methionine-initator methionine tRNA." [GOC:hjd, ISBN:9781555810733] comment: An example of this is eukaryotic initiation factor 2 complex, which binds the methionyl-initiator methionine tRNA during ternary complex formation. The non-acylated tRNA is not bound. is_a: GO:0000049 ! tRNA binding created_by: hjd creation_date: 2015-09-18T16:56:59Z [Term] id: GO:1990857 name: obsolete APC-Fzr1/Mfr1 complex namespace: cellular_component def: "OBSOLETE. An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family." [PMID:11493649] comment: This term was made obsolete because it is too fine-grained for GO. is_obsolete: true consider: GO:0005680 created_by: al creation_date: 2015-09-22T13:29:11Z [Term] id: GO:1990858 name: cellular response to lectin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444] comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. is_a: GO:1990840 ! response to lectin created_by: sl creation_date: 2015-09-24T15:34:42Z [Term] id: GO:1990859 name: cellular response to endothelin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1990839 ! response to endothelin created_by: sl creation_date: 2015-09-24T15:39:48Z [Term] id: GO:1990860 name: Pho85-Pho80 CDK-cyclin complex namespace: cellular_component def: "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin." [GOC:rb, PMID:8108735] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: rb creation_date: 2015-09-24T17:53:50Z [Term] id: GO:1990861 name: Ubp3-Bre5 deubiquitination complex namespace: cellular_component def: "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p." [GOC:rb, PMID:12778054, PMID:18391941] synonym: "Ubp3-Bre5 ubiquitin protease complex" EXACT [] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2015-09-24T17:56:53Z [Term] id: GO:1990862 name: nuclear membrane complex Bqt3-Bqt4 namespace: cellular_component def: "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4." [PMID:19948484] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005639 ! integral component of nuclear inner membrane created_by: al creation_date: 2015-09-25T12:14:28Z [Term] id: GO:1990863 name: acinar cell proliferation namespace: biological_process def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] synonym: "acinic cell proliferation" EXACT [] synonym: "acinous cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation created_by: sl creation_date: 2015-09-25T14:26:09Z [Term] id: GO:1990864 name: response to growth hormone-releasing hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins." [PMID:7720628] synonym: "response to GHRF" EXACT [] synonym: "response to GRF" EXACT [] synonym: "response to growth hormone-releasing factor" EXACT [] synonym: "response to sermorelin" RELATED [] synonym: "response to somatocrinin" EXACT [] synonym: "response to somatoliberin" EXACT [] synonym: "response to somatorelin" EXACT [] is_a: GO:0009725 ! response to hormone created_by: sl creation_date: 2015-09-25T14:45:31Z [Term] id: GO:1990865 name: obsolete response to intermittent hypoxia namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension." [PMID:24055447] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-09-25T15:07:32Z [Term] id: GO:1990866 name: obsolete response to sustained hypoxia namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension." [PMID:24055447] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-09-25T15:18:11Z [Term] id: GO:1990867 name: response to gastrin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814] is_a: GO:0043434 ! response to peptide hormone created_by: sl creation_date: 2015-09-25T16:22:39Z [Term] id: GO:1990868 name: response to chemokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082] is_a: GO:0034097 ! response to cytokine created_by: sl creation_date: 2015-09-25T16:37:00Z [Term] id: GO:1990869 name: cellular response to chemokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082] is_a: GO:0071345 ! cellular response to cytokine stimulus is_a: GO:1990868 ! response to chemokine created_by: sl creation_date: 2015-09-25T16:39:55Z [Term] id: GO:1990870 name: obsolete protein fibril namespace: cellular_component def: "OBSOLETE. A polymer of proteins that form a fine fiber." [PMID:12764608] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-09-25T17:05:32Z [Term] id: GO:1990871 name: Vma12-Vma22 assembly complex namespace: cellular_component def: "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p." [GOC:rb, PMID:9660861] is_a: GO:0032991 ! protein-containing complex created_by: rb creation_date: 2015-09-28T19:03:28Z [Term] id: GO:1990872 name: negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter." [GOC:rb, PMID:19793923] comment: An example of this is CLA4, STE20 and SKM1 in yeast in PMID:19793923, inferred by IMP. synonym: "negative regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol import by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] is_a: GO:0035968 ! regulation of sterol import by regulation of transcription from RNA polymerase II promoter is_a: GO:0072368 ! regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter is_a: GO:2000910 ! negative regulation of sterol import intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: negatively_regulates GO:0035376 ! sterol import created_by: rb creation_date: 2015-09-28T21:22:23Z [Term] id: GO:1990873 name: intrinsic component of plasma membrane of cell tip namespace: cellular_component def: "The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip." [PMID:20624220] is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0031520 ! plasma membrane of cell tip relationship: part_of GO:0031520 ! plasma membrane of cell tip created_by: al creation_date: 2015-09-29T10:06:25Z [Term] id: GO:1990874 name: vascular smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] synonym: "VSMC proliferation" EXACT [] is_a: GO:0048659 ! smooth muscle cell proliferation created_by: sl creation_date: 2015-09-29T16:34:59Z [Term] id: GO:1990875 name: nucleoplasmic side of nuclear pore namespace: cellular_component def: "The side of the nuclear pore complex (NPC) that faces the nucleoplasm." [PMID:8422679] synonym: "nucleoplasmic side of NPC" EXACT [] synonym: "nucleoplasmic side of nuclear pore complex" EXACT [] synonym: "nucleoplasmic side of nucleopore" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005643 ! nuclear pore created_by: sl creation_date: 2015-10-01T21:32:22Z [Term] id: GO:1990876 name: cytoplasmic side of nuclear pore namespace: cellular_component def: "The side of the nuclear pore complex (NPC) that faces the cytoplasm." [PMID:8422679] synonym: "cytoplasmic side of NPC" EXACT [] synonym: "cytoplasmic side of nuclear pore complex" EXACT [] synonym: "cytoplasmic side of nucleopore" EXACT [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005643 ! nuclear pore created_by: sl creation_date: 2015-10-01T21:47:54Z [Term] id: GO:1990877 name: Lst4-Lst7 complex namespace: cellular_component def: "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains Follicular (FLCN) and either follicular interaction protein 1 (FNIP1) or FNIP2." [GOC:rn, PMID:24095279, PMID:26387955] synonym: "FLCN-FNIP1 complex" RELATED [] synonym: "FLCN-FNIP2 complex" RELATED [] synonym: "FNIP-Folliculin RagC/D GAP complex" RELATED [] xref: PMID:24095279 xref: PMID:26387955 is_a: GO:1902773 ! GTPase activator complex created_by: rb creation_date: 2015-10-01T22:44:58Z [Term] id: GO:1990878 name: cellular response to gastrin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1990867 ! response to gastrin created_by: sl creation_date: 2015-10-07T17:38:14Z [Term] id: GO:1990879 name: CST complex namespace: cellular_component def: "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356] synonym: "Cdc13-Stn1-Ten1 complex" NARROW [GOC:nc] synonym: "CTC1-OBFC1-TEN1 complex" NARROW [GOC:nc] xref: IntAct:EBI-10043724 xref: IntAct:EBI-8801830 xref: IntAct:EBI-8801947 is_a: GO:0000783 ! nuclear telomere cap complex created_by: nc creation_date: 2015-10-20T13:51:07Z [Term] id: GO:1990880 name: cellular detoxification of copper ion namespace: biological_process def: "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [PMID:10369673] is_a: GO:0010273 ! detoxification of copper ion is_a: GO:1990748 ! cellular detoxification relationship: part_of GO:0071280 ! cellular response to copper ion created_by: al creation_date: 2015-10-21T14:34:40Z [Term] id: GO:1990881 name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:26150418] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "down regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] is_obsolete: true created_by: mcc creation_date: 2015-10-28T13:02:18Z [Term] id: GO:1990882 name: rRNA acetylation namespace: biological_process def: "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [PMID:25402480] is_a: GO:0000154 ! rRNA modification is_a: GO:1990884 ! RNA acetylation created_by: al creation_date: 2015-10-28T13:24:58Z [Term] id: GO:1990883 name: rRNA cytidine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480] is_a: GO:0008080 ! N-acetyltransferase activity created_by: al creation_date: 2015-10-28T13:27:35Z [Term] id: GO:1990884 name: RNA acetylation namespace: biological_process def: "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule." [PMID:25402480] is_a: GO:0009451 ! RNA modification created_by: mah creation_date: 2015-10-28T16:28:08Z [Term] id: GO:1990885 name: obsolete protein serine/threonine kinase binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a protein serine/threonine kinase." [PMID:16982699] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-10-28T20:40:57Z [Term] id: GO:1990887 name: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+." [PMID:10419476] is_a: GO:0008171 ! O-methyltransferase activity created_by: sl creation_date: 2015-10-28T22:17:54Z [Term] id: GO:1990888 name: 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+." [PMID:10419476] is_a: GO:0008171 ! O-methyltransferase activity created_by: sl creation_date: 2015-10-28T22:31:13Z [Term] id: GO:1990889 name: H4K20me3 modified histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone H4 in which the lysine residue at position 20 has been modified by trimethylation." [PMID:22150589] is_a: GO:0035064 ! methylated histone binding created_by: al creation_date: 2015-10-30T15:43:09Z [Term] id: GO:1990890 name: netrin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a netrin receptor." [GOC:kmv, PMID:8861902, PMID:9126742] is_a: GO:0005102 ! signaling receptor binding relationship: part_of GO:0038007 ! netrin-activated signaling pathway created_by: kmv creation_date: 2015-11-02T22:56:07Z [Term] id: GO:1990891 name: mitotic sister chromatid arm separation namespace: biological_process def: "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis." [PMID:21633354] is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0051306 ! mitotic sister chromatid separation created_by: mah creation_date: 2015-11-03T14:01:16Z [Term] id: GO:1990892 name: mitotic chromosome arm condensation namespace: biological_process def: "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [PMID:21633354] is_a: GO:0007076 ! mitotic chromosome condensation created_by: vw creation_date: 2015-11-03T14:16:59Z [Term] id: GO:1990893 name: mitotic chromosome centromere condensation namespace: biological_process def: "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis." [PMID:21633354] synonym: "mitotic chromosome condensation at kinetochore" EXACT [] is_a: GO:0007076 ! mitotic chromosome condensation created_by: vw creation_date: 2015-11-03T14:26:29Z [Term] id: GO:1990894 name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [PMID:22144909] comment: This term was obsoleted during the TG review process. It should have been created using a template. is_obsolete: true created_by: al creation_date: 2015-11-04T20:25:21Z [Term] id: GO:1990895 name: regulation of protein localization to cell cortex of cell tip namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [PMID:26150232\,GOC\:vw] is_a: GO:1903066 ! regulation of protein localization to cell tip is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1990896 ! protein localization to cell cortex of cell tip relationship: regulates GO:1990896 ! protein localization to cell cortex of cell tip created_by: vw creation_date: 2015-11-04T21:53:15Z [Term] id: GO:1990896 name: protein localization to cell cortex of cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip." [PMID:26150232] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:1990151 ! protein localization to cell tip created_by: vw creation_date: 2015-11-05T08:41:49Z [Term] id: GO:1990897 name: obsolete CTDK-1 complex namespace: cellular_component def: "OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13." [PMID:20952539, PMID:24879308] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2015-11-06T01:57:32Z [Term] id: GO:1990898 name: meiotic DNA double-strand break clipping namespace: biological_process def: "The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP)." [PMID:26130711] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination created_by: al creation_date: 2015-11-10T17:12:27Z [Term] id: GO:1990899 name: meiotic DNA double-strand break resectioning namespace: biological_process def: "The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." [PMID:26130711] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination created_by: al creation_date: 2015-11-10T17:23:07Z [Term] id: GO:1990900 name: ciliary pocket collar namespace: cellular_component def: "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma." [GOC:giardia, PMID:18462016, PMID:19806154] comment: Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli. synonym: "cilium pocket collar" EXACT [] synonym: "flagellar collar" RELATED [] synonym: "flagellar pocket collar" EXACT [] synonym: "flagellar pore" RELATED [] synonym: "flagellum pocket collar" EXACT [] synonym: "FPC" RELATED [] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0020016 ! ciliary pocket created_by: pr creation_date: 2015-11-17T14:43:55Z [Term] id: GO:1990901 name: old cell pole namespace: cellular_component def: "The cell pole distal from the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658] is_a: GO:0060187 ! cell pole created_by: pr creation_date: 2015-11-17T16:42:16Z [Term] id: GO:1990902 name: new cell pole namespace: cellular_component def: "The cell pole proximal to the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658] is_a: GO:0060187 ! cell pole created_by: pr creation_date: 2015-11-17T16:44:53Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component alt_id: GO:0030529 alt_id: GO:1990903 def: "A macromolecular complex containing both protein and RNA molecules." [GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "ribonucleoprotein complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex created_by: pr creation_date: 2015-11-19T12:26:37Z [Term] id: GO:1990905 name: dinoflagellate peduncle namespace: cellular_component def: "A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy)." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate, http://species-identification.org/index.php, PMID:1480107] comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. is_a: GO:0120025 ! plasma membrane bounded cell projection created_by: pr creation_date: 2015-11-22T10:22:46Z [Term] id: GO:1990906 name: accessory outer segment namespace: cellular_component def: "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors." [GOC:dph, PMID:25125189] is_a: GO:0043005 ! neuron projection created_by: dph creation_date: 2015-11-24T13:56:06Z [Term] id: GO:1990907 name: beta-catenin-TCF complex namespace: cellular_component def: "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] synonym: "beta-catenin/LEF complex" NARROW [PMID:8757136] synonym: "beta-catenin/lymphoid enhancer binding factor complex" RELATED [PMID:8757136] synonym: "beta-catenin/T-cell factor complex" RELATED [GOC:bf] xref: IntAct:EBI-11424678 xref: IntAct:EBI-11425837 is_a: GO:0090575 ! RNA polymerase II transcription factor complex created_by: bf creation_date: 2015-12-01T16:32:44Z [Term] id: GO:1990908 name: obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity namespace: molecular_function def: "OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile." [PMID:26368668] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2015-12-03T14:25:04Z [Term] id: GO:1990909 name: Wnt signalosome namespace: cellular_component def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription. synonym: "LRP5/6 signalosome" EXACT [GOC:bf] synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807] synonym: "Wnt signalosome complex" EXACT [PMID:24412065] synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894] is_a: GO:0032991 ! protein-containing complex relationship: has_part GO:1990851 ! Wnt-Frizzled-LRP5/6 complex created_by: bf creation_date: 2015-12-07T14:04:23Z [Term] id: GO:1990910 name: response to hypobaric hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level)." [PMID:24590457] is_a: GO:0001666 ! response to hypoxia created_by: sl creation_date: 2015-12-07T19:34:14Z [Term] id: GO:1990911 name: response to psychosocial stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism." [PMID:22922217, PMID:26458179] is_a: GO:0006950 ! response to stress created_by: sl creation_date: 2015-12-07T20:38:35Z [Term] id: GO:1990912 name: obsolete response to microwave radiation namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus." [PMID:21241601] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2015-12-07T21:25:08Z [Term] id: GO:1990913 name: sperm head plasma membrane namespace: cellular_component def: "The plasma membrane that is part of the head section of a sperm cell." [PMID:24478030] is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: part_of GO:0061827 ! sperm head relationship: part_of GO:0061827 ! sperm head relationship: part_of GO:0097524 ! sperm plasma membrane created_by: sl creation_date: 2015-12-07T23:14:04Z [Term] id: GO:1990914 name: integral component of periplasmic side of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane." [GOC:bhm, PMID:15919996] comment: An example of this is hyaA in E. coli (P69739) in PMID:23260654 (inferred from direct assay). xref: IntAct:EBI-11297444 is_a: GO:0031237 ! intrinsic component of periplasmic side of plasma membrane is_a: GO:0071575 ! integral component of external side of plasma membrane intersection_of: GO:0005887 ! integral component of plasma membrane intersection_of: part_of GO:0098567 ! periplasmic side of plasma membrane created_by: bhm creation_date: 2015-12-09T14:38:57Z [Term] id: GO:1990915 name: structural constituent of ascospore wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an ascospore wall." [PMID:24623719] is_a: GO:0005199 ! structural constituent of cell wall intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0005619 ! ascospore wall relationship: occurs_in GO:0005619 ! ascospore wall created_by: al creation_date: 2015-12-09T19:04:53Z [Term] id: GO:1990916 name: Isp3 layer of spore wall namespace: cellular_component def: "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe." [PMID:24623719] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005619 ! ascospore wall created_by: al creation_date: 2015-12-09T19:07:23Z [Term] id: GO:1990917 name: ooplasm namespace: cellular_component def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm created_by: sl creation_date: 2015-12-10T21:40:16Z [Term] id: GO:1990918 name: double-strand break repair involved in meiotic recombination namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514] is_a: GO:0006302 ! double-strand break repair is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination created_by: al creation_date: 2015-12-11T01:01:14Z [Term] id: GO:1990919 name: nuclear membrane proteasome anchor namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome complex and a nuclear inner membrane, in order to maintain the nuclear membrane localization of the proteasome." [PMID:16096059] synonym: "nuclear membrane proteasome adaptor" RELATED [] synonym: "tethering factor for nuclear proteasome" RELATED [] is_a: GO:0043495 ! protein membrane adaptor created_by: vw creation_date: 2015-12-14T14:01:45Z [Term] id: GO:1990920 name: proteasome localization to nuclear periphery namespace: biological_process def: "Any process in which the proteasome is transported to, or maintained at the nuclear periphery." [PMID:11084332] is_a: GO:0031144 ! proteasome localization is_a: GO:1990139 ! protein localization to nuclear periphery created_by: vw creation_date: 2015-12-14T17:14:00Z [Term] id: GO:1990921 name: obsolete proteasome localization to nuclear periphery namespace: biological_process def: "OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery." [PMID:16096059] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "proteasome localisation to nuclear periphery" EXACT [] is_obsolete: true created_by: mah creation_date: 2015-12-15T12:02:31Z [Term] id: GO:1990922 name: hepatic stellate cell proliferation namespace: biological_process def: "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260] synonym: "hepatic perisinusoidal cell proliferation" EXACT [] synonym: "Ito cell proliferation" EXACT [] synonym: "perisinusoidal cell proliferation" EXACT [] is_a: GO:0048144 ! fibroblast proliferation created_by: sl creation_date: 2016-01-13T23:12:57Z [Term] id: GO:1990923 name: PET complex namespace: cellular_component def: "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs" [PMID:26669262] is_a: GO:0032991 ! protein-containing complex created_by: sp creation_date: 2016-01-14T02:19:39Z [Term] id: GO:1990924 name: obsolete amphisome membrane namespace: cellular_component def: "OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm." [GOC:bhm, PMID:17984323] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "amphisomal membrane" EXACT [] is_obsolete: true created_by: bhm creation_date: 2016-01-27T13:58:16Z [Term] id: GO:1990926 name: short-term synaptic potentiation namespace: biological_process def: "The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds." [GOC:dos, GOC:sp, ISBN:9780071120005, PMID:11826273, PMID:26738595] comment: The mechanism of short term potentiation is thought to be either increased influx of calcium into the presynapse (Zucker and Regeh, 2002 PMID:11826273) increased sensitivity to calcium (Jackman et al., 2016 PMID:26738595) or both. synonym: "synaptic facilitation" EXACT [ISBN:9780071120005, PMID:11826273, PMID:26738595] is_a: GO:0048167 ! regulation of synaptic plasticity created_by: sp creation_date: 2016-02-12T13:17:18Z [Term] id: GO:1990927 name: calcium ion regulated lysosome exocytosis namespace: biological_process def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [PMID:10725327, PMID:11511344] is_a: GO:0017156 ! calcium-ion regulated exocytosis created_by: sp creation_date: 2016-02-16T14:19:44Z [Term] id: GO:1990928 name: response to amino acid starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311] is_a: GO:0042594 ! response to starvation created_by: sl creation_date: 2016-02-18T00:18:23Z [Term] id: GO:1990929 name: sulfoquinovosidase activity namespace: molecular_function def: "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose." [GOC:imk, PMID:26878550] is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds created_by: tb creation_date: 2016-02-19T01:18:37Z [Term] id: GO:1990930 name: RNA N1-methyladenosine dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde." [PMID:26863196, PMID:26863410] is_a: GO:0035515 ! oxidative RNA demethylase activity created_by: sp creation_date: 2016-03-10T08:06:47Z [Term] id: GO:1990931 name: RNA N6-methyladenosine dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde." [PMID:22002720, PMID:26458103] is_a: GO:0035515 ! oxidative RNA demethylase activity created_by: sp creation_date: 2016-03-10T08:10:10Z [Term] id: GO:1990932 name: 5.8S rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA." [PMID:11716358, PMID:15527424] is_a: GO:0019843 ! rRNA binding created_by: sl creation_date: 2016-03-14T20:25:41Z [Term] id: GO:1990933 name: microtubule cytoskeleton attachment to nuclear envelope namespace: biological_process def: "A process in which the microtubule cytoskeleton is attached to the nuclear envelope." [PMID:14655046, PMID:20507227] is_a: GO:0007010 ! cytoskeleton organization created_by: vw creation_date: 2016-03-17T08:32:37Z [Term] id: GO:1990934 name: nucleolus-like body namespace: cellular_component def: "A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles." [PMID:26226217, PMID:9021878] synonym: "compact nucleolus" EXACT [] synonym: "NLB" EXACT [] synonym: "nucleolus-like body" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: part_of GO:0031981 ! nuclear lumen created_by: sl creation_date: 2016-03-21T21:28:14Z [Term] id: GO:1990935 name: splicing factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA." [PMID:11118435] is_a: GO:0005515 ! protein binding created_by: sl creation_date: 2016-03-21T21:57:20Z [Term] id: GO:1990936 name: vascular smooth muscle cell dedifferentiation namespace: biological_process def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079] is_a: GO:0090678 ! cell dedifferentiation involved in phenotypic switching created_by: tb creation_date: 2016-03-22T20:25:11Z [Term] id: GO:1990937 name: xylan acetylation namespace: biological_process def: "The addition of one or more acetyl groups to a xylan molecule." [PMID:26745802] is_a: GO:0043412 ! macromolecule modification is_a: GO:0045491 ! xylan metabolic process created_by: tb creation_date: 2016-03-30T22:10:22Z [Term] id: GO:1990938 name: peptidyl-aspartic acid autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein." [GOC:bf, GOC:PARL, PMID:26134396] synonym: "aspartyl autophosphorylation" EXACT [PMID:26134396] synonym: "peptidyl-aspartate autophosphorylation" EXACT [GOC:bf] is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation is_a: GO:0046777 ! protein autophosphorylation created_by: bf creation_date: 2016-04-04T10:49:53Z [Term] id: GO:1990939 name: ATP-dependent microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP." [PMID:19686686] xref: Reactome:R-HSA-9610627 "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane" is_a: GO:0003777 ! microtubule motor activity is_a: GO:0042623 ! ATPase activity, coupled created_by: vw creation_date: 2016-04-04T10:59:42Z [Term] id: GO:1990940 name: obsolete microtubule sliding involved in mitotic spindle elongation namespace: biological_process def: "OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation." [PMID:19686686] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: vw creation_date: 2016-04-04T11:06:41Z [Term] id: GO:1990941 name: mitotic spindle kinetochore microtubule namespace: cellular_component def: "Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation." [PMID:18256284] is_a: GO:0005828 ! kinetochore microtubule is_a: GO:1990498 ! mitotic spindle microtubule created_by: vw creation_date: 2016-04-06T13:31:38Z [Term] id: GO:1990942 name: mitotic metaphase chromosome recapture namespace: biological_process def: "A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate." [PMID:18256284] synonym: "kinetochore retrieval" EXACT [] synonym: "metaphase chromosome retrieval to the spindle pole body" EXACT [] synonym: "sister kinetochore recapture" EXACT [] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0007080 ! mitotic metaphase plate congression created_by: vw creation_date: 2016-04-06T14:41:56Z [Term] id: GO:1990943 name: mating type region replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with the replication fork barrier found in the mating type region of fission yeast." [PMID:18723894] synonym: "RTS1 barrier binding" EXACT [] synonym: "RTS1 element binding" EXACT [] is_a: GO:0031634 ! replication fork barrier binding created_by: mah creation_date: 2016-04-06T16:08:43Z [Term] id: GO:1990944 name: maintenance of spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is maintained in a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [PMID:12390246] synonym: "maintenance of SPB localization" EXACT [] synonym: "maintenance of spindle pole body localisation" EXACT [] synonym: "maintenance of spindle pole body location" EXACT [] is_a: GO:0051657 ! maintenance of organelle location relationship: part_of GO:0070631 ! spindle pole body localization created_by: mah creation_date: 2016-04-11T12:16:59Z [Term] id: GO:1990946 name: meiosis I/meiosis II transition namespace: biological_process def: "The cell cycle process in which a cell progresses from meiosis I to meiosis II." [PMID:21389117] is_a: GO:0044771 ! meiotic cell cycle phase transition created_by: vw creation_date: 2016-04-21T13:01:07Z [Term] id: GO:1990947 name: exit from meiosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half." [PMID:21389117] synonym: "meiotic exit" EXACT [GOC:dph] is_a: GO:0044771 ! meiotic cell cycle phase transition created_by: vw creation_date: 2016-04-21T14:14:15Z [Term] id: GO:1990948 name: ubiquitin ligase inhibitor activity namespace: molecular_function alt_id: GO:0061637 alt_id: GO:0090645 def: "Stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] synonym: "APC-Cdc20 complex inhibitor activity" NARROW [] synonym: "mitotic anaphase-promoting complex inhibitor activity" NARROW [] is_a: GO:0055105 ! ubiquitin-protein transferase inhibitor activity relationship: part_of GO:1904667 ! negative regulation of ubiquitin protein ligase activity created_by: vw creation_date: 2016-04-21T16:36:54Z [Term] id: GO:1990949 name: metaphase/anaphase transition of meiosis I namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I." [ISBN:0815316194] synonym: "first meiotic metaphase/anaphase transition" RELATED [] synonym: "meiosis I metaphase/anaphase transition" EXACT [] is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle is_a: GO:0061982 ! meiosis I cell cycle process created_by: mah creation_date: 2016-04-25T15:27:32Z [Term] id: GO:1990950 name: metaphase/anaphase transition of meiosis II namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II." [ISBN:0815316194] synonym: "meiosis II metaphase/anaphase transition" EXACT [] synonym: "second meiotic metaphase/anaphase transition" RELATED [] is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle is_a: GO:0061983 ! meiosis II cell cycle process created_by: mah creation_date: 2016-04-25T15:28:51Z [Term] id: GO:1990951 name: obsolete manchette assembly namespace: biological_process def: "OBSOLETE. The assembly and organization of the manchette, a tubular array of microtubules, possibly also containing actin filaments, that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: krc creation_date: 2016-05-11T00:05:35Z [Term] id: GO:1990952 name: obsolete manchette disassembly namespace: biological_process def: "OBSOLETE. A cellular process that results in the breakdown of a manchette." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "manchette clearance" EXACT [] is_obsolete: true created_by: krc creation_date: 2016-05-11T00:14:16Z [Term] id: GO:1990953 name: intramanchette transport namespace: biological_process def: "The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] synonym: "IMT" RELATED [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098840 ! protein transport along microtubule relationship: occurs_in GO:0002177 ! manchette relationship: part_of GO:0007286 ! spermatid development created_by: krc creation_date: 2016-05-11T00:17:56Z [Term] id: GO:1990954 name: establishment of protein localization to meiotic spindle pole body namespace: biological_process def: "The directed movement of a protein to a specific location at the meiotic spindle pole body." [PMID:20833892] is_a: GO:0071989 ! establishment of protein localization to spindle pole body is_a: GO:1902441 ! protein localization to meiotic spindle pole body created_by: vw creation_date: 2016-05-12T14:45:50Z [Term] id: GO:1990955 name: G-rich single-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-rich, single-stranded DNA." [GOC:hjd, PMID:8493094] is_a: GO:0003697 ! single-stranded DNA binding created_by: hjd creation_date: 2016-05-13T17:44:28Z [Term] id: GO:1990956 name: fibroblast chemotaxis namespace: biological_process def: "The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph, PMID:8760137] is_a: GO:0060326 ! cell chemotaxis created_by: dph creation_date: 2016-06-02T19:54:19Z [Term] id: GO:1990957 name: NPHP complex namespace: cellular_component def: "A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways." [GOC:cilia, PMID:18337471, PMID:21422230, PMID:21498478, PMID:21555462, PMID:25150219] comment: Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme. synonym: "NPHP module" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0035869 ! ciliary transition zone created_by: pr creation_date: 2016-06-06T10:59:45Z [Term] id: GO:1990958 name: obsolete response to thyrotropin-releasing hormone namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [PMID:21382270] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "response to TRH" RELATED [] is_obsolete: true created_by: sl creation_date: 2016-06-06T21:07:34Z [Term] id: GO:1990959 name: eosinophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] synonym: "eosinocyte homeostasis" EXACT [] synonym: "eosinophilic granulocyte homeostasis" EXACT [] synonym: "eosinophilic leucocyte homeostasis" EXACT [] synonym: "eosinophilic leukocyte homeostasis" EXACT [] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis created_by: sl creation_date: 2016-06-06T22:34:31Z [Term] id: GO:1990960 name: basophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] synonym: "basophilic leucocyte homeostasis" EXACT [] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis created_by: sl creation_date: 2016-06-06T22:38:22Z [Term] id: GO:1990961 name: xenobiotic detoxification by transmembrane export across the plasma membrane namespace: biological_process def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell." [PMID:28355133] comment: Changed definiton as requested: https://github.com/geneontology/go-ontology/issues/17141 synonym: "drug transmembrane export" NARROW [] is_a: GO:0042908 ! xenobiotic transport is_a: GO:0140115 ! export across plasma membrane relationship: part_of GO:0098754 ! detoxification created_by: sl creation_date: 2016-06-06T23:47:22Z [Term] id: GO:1990962 name: xenobiotic transport across blood-brain barrier namespace: biological_process def: "The directed movement of a xenobiotic through the blood-brain barrier." [PMID:25053619] synonym: "drug transport across blood-brain barrier" RELATED [] is_a: GO:0042908 ! xenobiotic transport is_a: GO:0150104 ! transport across blood-brain barrier created_by: sl creation_date: 2016-06-07T17:39:33Z [Term] id: GO:1990963 name: establishment of blood-retinal barrier namespace: biological_process def: "Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the \"nonleaky\" type." [PMID:25053619] synonym: "establishment of blood-retina barrier" EXACT [] synonym: "establishment of BRB" RELATED [] is_a: GO:0048468 ! cell development created_by: sl creation_date: 2016-06-07T21:17:55Z [Term] id: GO:1990964 name: actin cytoskeleton-regulatory complex namespace: cellular_component def: "A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat." [GOC:bhm, PMID:10594004, PMID:11739778] comment: An example of this is Pan1 in Saccharomyces cerevisiae (UniProt ID P32521) in PMID:10594004 (inferred from direct assay). xref: IntAct:EBI-11710254 is_a: GO:0032991 ! protein-containing complex created_by: bhm creation_date: 2016-06-09T12:18:30Z [Term] id: GO:1990965 name: cytosylglucuronate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: cytosylglucuronic acid + H(+) = cytosylarabinopyranose + CO(2)." [GOC:pr, GOC:tb, PMID:23874663] comment: This enzymatic activity was shown to be involved in the bacterial blasticidin S biosynthetic pathway. is_a: GO:0016831 ! carboxy-lyase activity created_by: pr creation_date: 2016-06-09T13:05:27Z [Term] id: GO:1990966 name: ATP generation from poly-ADP-D-ribose namespace: biological_process def: "The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0046034 ! ATP metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: sp creation_date: 2016-06-16T09:41:35Z [Term] id: GO:1990967 name: obsolete multi-organism toxin transport namespace: biological_process def: "OBSOLETE. The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved." [GOC:bf, GOC:PARL, PMID:18191792, PMID:22042847] comment: This term was obsoleted because there is no evidence that this process exists. synonym: "typhoid toxin transport" NARROW [PMID:22042847] is_obsolete: true created_by: bf creation_date: 2016-06-21T09:01:39Z [Term] id: GO:1990968 name: modulation by host of RNA binding by virus namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA." [GOC:bf, GOC:PARL, PMID:25116364] comment: Note that the bound RNA may originate from the virus or another organism, including the host. synonym: "modulation by host of viral protein:RNA interaction" RELATED [GOC:bf] is_a: GO:0044868 ! modulation by host of viral molecular function is_a: GO:1905214 ! regulation of RNA binding created_by: bf creation_date: 2016-06-21T11:56:10Z [Term] id: GO:1990969 name: modulation by host of viral RNA-binding transcription factor activity namespace: biological_process def: "A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor." [GOC:bf, GOC:PARL, PMID:25116364] synonym: "modulation by host of viral Tat activity" NARROW [PMID:25116364] is_a: GO:0043921 ! modulation by host of viral transcription is_a: GO:0052428 ! modulation by host of symbiont molecular function is_a: GO:1905255 ! regulation of RNA binding transcription factor activity intersection_of: GO:0052428 ! modulation by host of symbiont molecular function intersection_of: regulates GO:0001070 ! RNA-binding transcription regulator activity created_by: bf creation_date: 2016-06-21T12:12:31Z [Term] id: GO:1990970 name: trans-activation response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter." [GOC:bf, GOC:PARL, PMID:25116364, Wikipedia:Trans-activation_response_element_(TAR)] synonym: "TAR binding" EXACT [PMID:25116364] is_a: GO:0070883 ! pre-miRNA binding created_by: bf creation_date: 2016-06-21T12:23:00Z [Term] id: GO:1990971 name: EMILIN complex namespace: cellular_component def: "Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures." [GOC:bhm, PMID:10821830] comment: An example of this is EMILIN-1 in human (Q9Y6C2) in PMID:10821830 (inferred from direct assay). synonym: "Elastic microfibrillar interface 1 complex" NARROW [] synonym: "Elastic microfibrillar interface 2 complex" NARROW [] synonym: "EMILIN-1 complex" NARROW [] synonym: "EMILIN-2 complex" NARROW [] xref: IntAct:EBI-11705777 xref: IntAct:EBI-11740139 xref: IntAct:EBI-11740215 xref: IntAct:EBI-11740275 is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: bhm creation_date: 2016-06-21T14:41:18Z [Term] id: GO:1990972 name: multimerin complex namespace: cellular_component def: "Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures." [GOC:bhm, PMID:9454761] comment: An example of this is Multimerin-1 in human (Q13201) in PMID:9454761. synonym: "Elastic microfibrillar interface 3 complex" NARROW [] synonym: "Elastic microfibrillar interface 4 complex" NARROW [] synonym: "EMILIN-3 complex" NARROW [] synonym: "EMILIN-4 complex" NARROW [] synonym: "Multimerin-1 complex" NARROW [] synonym: "Multimerin-2 complex" NARROW [] synonym: "p155 complex" NARROW [] synonym: "Platelet glycoprotein Ia* complex" NARROW [] xref: IntAct:EBI-11783711 is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion relationship: part_of GO:0062023 ! collagen-containing extracellular matrix created_by: bhm creation_date: 2016-06-21T14:49:42Z [Term] id: GO:1990973 name: transmembrane actin-associated (TAN) line namespace: cellular_component def: "A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge)." [GOC:hjd, PMID:21173262] synonym: "TAN line" RELATED [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle created_by: hjd creation_date: 2016-06-22T15:05:09Z [Term] id: GO:1990974 name: actin-dependent nuclear migration namespace: biological_process def: "The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell." [GOC:hjd, PMID:21173262] synonym: "actin-dependent nuclear movement" RELATED [] is_a: GO:0007097 ! nuclear migration created_by: hjd creation_date: 2016-06-22T19:17:02Z [Term] id: GO:1990975 name: establishment of protein localization to mitotic spindle pole body namespace: biological_process def: "The directed movement of a protein to a specific location at the mitotic spindle pole body." [GOC:dos, PMID:15265986] is_a: GO:0071989 ! establishment of protein localization to spindle pole body is_a: GO:1902440 ! protein localization to mitotic spindle pole body created_by: vw creation_date: 2016-06-30T12:48:41Z [Term] id: GO:1990976 name: protein transport along microtubule to mitotic spindle pole body namespace: biological_process def: "The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins." [PMID:25987607] is_a: GO:1990852 ! protein transport along microtubule to spindle pole body is_a: GO:1990975 ! establishment of protein localization to mitotic spindle pole body created_by: vw creation_date: 2016-06-30T13:09:08Z [Term] id: GO:1990977 name: obsolete negative regulation of mitotic DNA replication initiation from late origin namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: al creation_date: 2016-07-11T14:56:38Z [Term] id: GO:1990978 name: obsolete response to viscosity namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [PMID:7061416] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sl creation_date: 2016-08-17T20:10:36Z [Term] id: GO:1990979 name: obsolete copper ion transport across blood-brain barrier namespace: biological_process def: "OBSOLETE. The directed movement of copper ions passing through the blood-brain barrier." [PMID:24614235] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "copper ion transport across BBB" RELATED [] is_obsolete: true created_by: sl creation_date: 2016-08-17T21:09:08Z [Term] id: GO:1990980 name: obsolete copper ion transport across blood-CSF barrier namespace: biological_process def: "OBSOLETE. The directed movement of copper ions passing through the blood-cerebrospinal fluid barrier." [PMID:24614235] comment: This term was obsoleted at the TermGenie Gatekeeper stage. synonym: "copper ion transport across BCB" EXACT [] synonym: "copper ion transport across blood-cerebrospinal fluid barrier" EXACT [] is_obsolete: true created_by: sl creation_date: 2016-08-17T21:14:18Z [Term] id: GO:1990981 name: obsolete regulation of protein localization to cell division site involved in cell separation after cytokinesis namespace: biological_process def: "OBSOLETE. A regulation of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: vw creation_date: 2016-08-21T19:43:21Z [Term] id: GO:1990982 name: obsolete Immune memory response namespace: biological_process def: "OBSOLETE. The immune response against a previously encountered antigen being quicker and quantitatively better compared with the primary response." [PMID:26831526] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: sp creation_date: 2016-09-01T10:57:56Z [Term] id: GO:1990983 name: tRNA demethylation namespace: biological_process def: "The removal of a methyl group from one or more residues within a tRNA molecule." [PMID:27745969] is_a: GO:0006400 ! tRNA modification is_a: GO:0035513 ! oxidative RNA demethylation created_by: sp creation_date: 2016-10-28T08:32:59Z [Term] id: GO:1990984 name: tRNA demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule." [PMID:27745969] is_a: GO:0035515 ! oxidative RNA demethylase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: sp creation_date: 2016-10-28T08:38:14Z [Term] id: GO:1990985 name: obsolete apoptosis in response to oxidative stress namespace: biological_process def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to oxidative stress." [GOC:pg, PMID:25950479] comment: This term was obsoleted at the TermGenie Gatekeeper stage. is_obsolete: true created_by: pg creation_date: 2016-11-17T14:12:17Z [Term] id: GO:1990986 name: DNA recombinase disassembly namespace: biological_process def: "The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases)." [GOC:pg, PMID:19540122] synonym: "Rad51 nucleoprotein filament disassembly" RELATED [] is_a: GO:0032986 ! protein-DNA complex disassembly is_a: GO:0043624 ! cellular protein complex disassembly created_by: pg creation_date: 2016-11-18T13:13:56Z [Term] id: GO:2000001 name: regulation of DNA damage checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] synonym: "regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:1901976 ! regulation of cell cycle checkpoint is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000077 ! DNA damage checkpoint relationship: regulates GO:0000077 ! DNA damage checkpoint created_by: janelomax creation_date: 2010-07-15T03:25:00Z [Term] id: GO:2000002 name: negative regulation of DNA damage checkpoint namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol] synonym: "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:1901977 ! negative regulation of cell cycle checkpoint is_a: GO:2000001 ! regulation of DNA damage checkpoint is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000077 ! DNA damage checkpoint relationship: negatively_regulates GO:0000077 ! DNA damage checkpoint created_by: janelomax creation_date: 2010-07-15T03:25:06Z [Term] id: GO:2000003 name: positive regulation of DNA damage checkpoint namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] synonym: "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] is_a: GO:1901978 ! positive regulation of cell cycle checkpoint is_a: GO:2000001 ! regulation of DNA damage checkpoint is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000077 ! DNA damage checkpoint relationship: positively_regulates GO:0000077 ! DNA damage checkpoint created_by: janelomax creation_date: 2010-07-15T03:25:10Z [Term] id: GO:2000004 name: regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072284 ! metanephric S-shaped body morphogenesis relationship: regulates GO:0072284 ! metanephric S-shaped body morphogenesis created_by: jane creation_date: 2010-07-30T02:14:33Z [Term] id: GO:2000005 name: negative regulation of metanephric S-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis relationship: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis created_by: jane creation_date: 2010-07-30T02:14:37Z [Term] id: GO:2000006 name: regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis relationship: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis created_by: jane creation_date: 2010-07-30T02:17:12Z [Term] id: GO:2000007 name: negative regulation of metanephric comma-shaped body morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis relationship: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis created_by: jane creation_date: 2010-07-30T02:17:17Z [Term] id: GO:2000008 name: regulation of protein localization to cell surface namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] synonym: "regulation of protein localisation at cell surface" EXACT [GOC:mah] synonym: "regulation of protein localization at cell surface" EXACT [] is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034394 ! protein localization to cell surface relationship: regulates GO:0034394 ! protein localization to cell surface created_by: jane creation_date: 2010-08-04T01:43:48Z [Term] id: GO:2000009 name: negative regulation of protein localization to cell surface namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] synonym: "negative regulation of protein localisation at cell surface" EXACT [GOC:mah] synonym: "negative regulation of protein localization at cell surface" EXACT [] is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:2000008 ! regulation of protein localization to cell surface intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034394 ! protein localization to cell surface relationship: negatively_regulates GO:0034394 ! protein localization to cell surface created_by: jane creation_date: 2010-08-04T01:43:52Z [Term] id: GO:2000010 name: positive regulation of protein localization to cell surface namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] synonym: "positive regulation of protein localisation at cell surface" EXACT [GOC:mah] synonym: "positive regulation of protein localization at cell surface" EXACT [] is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:2000008 ! regulation of protein localization to cell surface intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034394 ! protein localization to cell surface relationship: positively_regulates GO:0034394 ! protein localization to cell surface created_by: jane creation_date: 2010-08-04T01:43:56Z [Term] id: GO:2000011 name: regulation of adaxial/abaxial pattern formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol] synonym: "regulation of adaxial/abaxial pattern specification" RELATED [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009955 ! adaxial/abaxial pattern specification relationship: regulates GO:0009955 ! adaxial/abaxial pattern specification created_by: tanyaberardini creation_date: 2010-08-05T11:20:22Z [Term] id: GO:2000012 name: regulation of auxin polar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of auxin polar transport." [GOC:obol] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0051049 ! regulation of transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009926 ! auxin polar transport relationship: regulates GO:0009926 ! auxin polar transport created_by: tanyaberardini creation_date: 2010-08-05T11:21:09Z [Term] id: GO:2000013 name: regulation of arginine biosynthetic process via ornithine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol] synonym: "regulation of arginine anabolism via ornithine" EXACT [GOC:obol] synonym: "regulation of arginine formation via ornithine" EXACT [GOC:obol] synonym: "regulation of arginine synthesis via ornithine" EXACT [GOC:obol] is_a: GO:0090368 ! regulation of ornithine metabolic process is_a: GO:1900079 ! regulation of arginine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042450 ! arginine biosynthetic process via ornithine relationship: regulates GO:0042450 ! arginine biosynthetic process via ornithine created_by: tanyaberardini creation_date: 2010-08-05T11:21:51Z [Term] id: GO:2000014 name: regulation of endosperm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endosperm development." [GOC:obol] is_a: GO:0080050 ! regulation of seed development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009960 ! endosperm development relationship: regulates GO:0009960 ! endosperm development created_by: tanyaberardini creation_date: 2010-08-05T11:22:21Z [Term] id: GO:2000015 name: regulation of determination of dorsal identity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol] synonym: "regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048263 ! determination of dorsal identity relationship: regulates GO:0048263 ! determination of dorsal identity created_by: janelomax creation_date: 2010-07-15T03:27:49Z [Term] id: GO:2000016 name: negative regulation of determination of dorsal identity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:BHF, GOC:obol] synonym: "negative regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000015 ! regulation of determination of dorsal identity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048263 ! determination of dorsal identity relationship: negatively_regulates GO:0048263 ! determination of dorsal identity created_by: janelomax creation_date: 2010-07-15T03:27:55Z [Term] id: GO:2000017 name: positive regulation of determination of dorsal identity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol] synonym: "positive regulation of determination of adaxial identity" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000015 ! regulation of determination of dorsal identity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048263 ! determination of dorsal identity relationship: positively_regulates GO:0048263 ! determination of dorsal identity created_by: janelomax creation_date: 2010-07-15T03:27:59Z [Term] id: GO:2000018 name: regulation of male gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] synonym: "regulation of testicular development" EXACT [GOC:obol] synonym: "regulation of testis development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008584 ! male gonad development relationship: regulates GO:0008584 ! male gonad development created_by: janelomax creation_date: 2010-07-15T03:29:05Z [Term] id: GO:2000019 name: negative regulation of male gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] synonym: "negative regulation of testicular development" EXACT [GOC:obol] synonym: "negative regulation of testis development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000018 ! regulation of male gonad development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008584 ! male gonad development relationship: negatively_regulates GO:0008584 ! male gonad development created_by: janelomax creation_date: 2010-07-15T03:29:10Z [Term] id: GO:2000020 name: positive regulation of male gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol] synonym: "positive regulation of testicular development" EXACT [GOC:obol] synonym: "positive regulation of testis development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000018 ! regulation of male gonad development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008584 ! male gonad development relationship: positively_regulates GO:0008584 ! male gonad development created_by: janelomax creation_date: 2010-07-15T03:29:13Z [Term] id: GO:2000022 name: regulation of jasmonic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol] synonym: "regulation of jasmonic acid mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009867 ! jasmonic acid mediated signaling pathway relationship: regulates GO:0009867 ! jasmonic acid mediated signaling pathway created_by: tanyaberardini creation_date: 2010-08-05T11:24:11Z [Term] id: GO:2000023 name: regulation of lateral root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lateral root development." [GOC:obol] is_a: GO:2000069 ! regulation of post-embryonic root development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048527 ! lateral root development relationship: regulates GO:0048527 ! lateral root development created_by: tanyaberardini creation_date: 2010-08-05T11:24:50Z [Term] id: GO:2000024 name: regulation of leaf development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf development." [GOC:obol] is_a: GO:0048831 ! regulation of shoot system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048366 ! leaf development relationship: regulates GO:0048366 ! leaf development created_by: tanyaberardini creation_date: 2010-08-05T11:25:14Z [Term] id: GO:2000025 name: regulation of leaf formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leaf formation." [GOC:obol] is_a: GO:1901371 ! regulation of leaf morphogenesis is_a: GO:1905428 ! regulation of plant organ formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010338 ! leaf formation relationship: regulates GO:0010338 ! leaf formation created_by: tanyaberardini creation_date: 2010-08-05T11:25:37Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007275 ! multicellular organism development relationship: regulates GO:0007275 ! multicellular organism development created_by: tanyaberardini creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009887 ! animal organ morphogenesis relationship: regulates GO:0009887 ! animal organ morphogenesis created_by: tanyaberardini creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000028 name: regulation of photoperiodism, flowering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoperiodism, flowering." [GOC:obol] synonym: "regulation of photoperiodic control of flowering time" EXACT [GOC:obol] synonym: "regulation of photoperiodic control of inflorescence development" EXACT [GOC:obol] synonym: "regulation of response to day length, flowering" EXACT [GOC:obol] synonym: "regulation of response to night length, flowering" EXACT [GOC:obol] synonym: "regulation of response to photoperiod, flowering" EXACT [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048573 ! photoperiodism, flowering relationship: regulates GO:0048573 ! photoperiodism, flowering created_by: tanyaberardini creation_date: 2010-08-05T11:27:18Z [Term] id: GO:2000029 name: regulation of proanthocyanidin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol] synonym: "regulation of proanthocyanidin anabolism" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin biosynthesis" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin formation" EXACT [GOC:obol] synonym: "regulation of proanthocyanidin synthesis" EXACT [GOC:obol] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010023 ! proanthocyanidin biosynthetic process relationship: regulates GO:0010023 ! proanthocyanidin biosynthetic process created_by: tanyaberardini creation_date: 2010-08-05T11:28:08Z [Term] id: GO:2000030 name: regulation of response to red or far red light namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009639 ! response to red or far red light relationship: regulates GO:0009639 ! response to red or far red light created_by: tanyaberardini creation_date: 2010-08-05T11:30:10Z [Term] id: GO:2000031 name: regulation of salicylic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol] synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009863 ! salicylic acid mediated signaling pathway relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway created_by: tanyaberardini creation_date: 2010-08-05T11:32:24Z [Term] id: GO:2000032 name: regulation of secondary shoot formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary shoot formation." [GOC:obol] synonym: "regulation of auxiliary shoot formation" RELATED [GOC:obol] synonym: "regulation of axillary shoot formation" RELATED [GOC:obol] synonym: "regulation of axillary shoot system formation" EXACT [] synonym: "regulation of shoot branching" RELATED [] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1900618 ! regulation of shoot system morphogenesis is_a: GO:1905428 ! regulation of plant organ formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010223 ! secondary shoot formation relationship: regulates GO:0010223 ! secondary shoot formation created_by: tanyaberardini creation_date: 2010-08-05T11:32:50Z [Term] id: GO:2000033 name: regulation of seed dormancy process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed dormancy process." [GOC:obol, GOC:pr, ISBN:9781405139830] synonym: "regulation of seed dormancy" RELATED [] is_a: GO:2000034 ! regulation of seed maturation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010162 ! seed dormancy process relationship: regulates GO:0010162 ! seed dormancy process created_by: tanyaberardini creation_date: 2010-08-05T11:33:13Z [Term] id: GO:2000034 name: regulation of seed maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0080050 ! regulation of seed development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010431 ! seed maturation relationship: regulates GO:0010431 ! seed maturation created_by: tanyaberardini creation_date: 2010-08-05T11:33:33Z [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017145 ! stem cell division relationship: regulates GO:0017145 ! stem cell division created_by: tanyaberardini creation_date: 2010-08-05T11:34:53Z [Term] id: GO:2000036 name: regulation of stem cell population maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol] synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019827 ! stem cell population maintenance relationship: regulates GO:0019827 ! stem cell population maintenance created_by: tanyaberardini creation_date: 2010-08-05T11:35:25Z [Term] id: GO:2000037 name: regulation of stomatal complex patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010375 ! stomatal complex patterning relationship: regulates GO:0010375 ! stomatal complex patterning created_by: tanyaberardini creation_date: 2010-08-05T11:35:47Z [Term] id: GO:2000038 name: regulation of stomatal complex development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010374 ! stomatal complex development relationship: regulates GO:0010374 ! stomatal complex development created_by: tanyaberardini creation_date: 2010-08-05T11:36:10Z [Term] id: GO:2000039 name: regulation of trichome morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol] synonym: "regulation of trichome cell morphogenesis during differentiation" EXACT [GOC:obol] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:2000024 ! regulation of leaf development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010090 ! trichome morphogenesis relationship: regulates GO:0010090 ! trichome morphogenesis created_by: tanyaberardini creation_date: 2010-08-05T11:36:31Z [Term] id: GO:2000040 name: regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation relationship: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation created_by: dph creation_date: 2010-08-18T02:47:49Z [Term] id: GO:2000041 name: negative regulation of planar cell polarity pathway involved in axis elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:2000040 ! regulation of planar cell polarity pathway involved in axis elongation is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation relationship: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation created_by: dph creation_date: 2010-08-18T02:47:54Z [Term] id: GO:2000042 name: negative regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw] synonym: "negative regulation of HDR" EXACT [GOC:obol] synonym: "negative regulation of homologous recombinational repair" EXACT [GOC:obol] synonym: "negative regulation of homology-directed repair" EXACT [GOC:obol] synonym: "negative regulation of HRR" EXACT [GOC:obol] synonym: "negative regulation of Rad51-dependent recombinational repair" EXACT [GOC:obol] synonym: "negative regulation of Rhp51-dependent recombinational repair" EXACT [GOC:obol] is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination is_a: GO:0045910 ! negative regulation of DNA recombination is_a: GO:2000780 ! negative regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination relationship: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination created_by: tanyaberardini creation_date: 2010-08-19T06:37:08Z [Term] id: GO:2000043 name: regulation of cardiac cell fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060912 ! cardiac cell fate specification relationship: regulates GO:0060912 ! cardiac cell fate specification created_by: tanyaberardini creation_date: 2010-08-19T09:01:04Z [Term] id: GO:2000044 name: negative regulation of cardiac cell fate specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000043 ! regulation of cardiac cell fate specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060912 ! cardiac cell fate specification relationship: negatively_regulates GO:0060912 ! cardiac cell fate specification created_by: tanyaberardini creation_date: 2010-08-19T09:01:10Z [Term] id: GO:2000045 name: regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'. is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle created_by: tanyaberardini creation_date: 2010-08-19T09:10:56Z [Term] id: GO:2000046 name: obsolete regulation of G2 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:vw] comment: This term was made obsolete because we felt that phases themselves are not being regulated, it's rather the transitions between phases. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transiition. synonym: "regulation of G2 phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0010389 created_by: tanyaberardini creation_date: 2010-08-19T09:19:18Z [Term] id: GO:2000047 name: regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin relationship: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin created_by: jane creation_date: 2010-08-20T12:56:44Z [Term] id: GO:2000048 name: negative regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin relationship: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin created_by: jane creation_date: 2010-08-20T12:56:51Z [Term] id: GO:2000049 name: positive regulation of cell-cell adhesion mediated by cadherin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin relationship: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin created_by: jane creation_date: 2010-08-20T12:56:57Z [Term] id: GO:2000050 name: regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jane creation_date: 2010-08-20T01:04:12Z [Term] id: GO:2000051 name: negative regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jane creation_date: 2010-08-20T01:04:20Z [Term] id: GO:2000052 name: positive regulation of non-canonical Wnt signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf] synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of non-canonical Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway relationship: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway created_by: jane creation_date: 2010-08-20T01:04:25Z [Term] id: GO:2000053 name: regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] synonym: "regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jane creation_date: 2010-08-20T01:13:28Z [Term] id: GO:2000054 name: negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] synonym: "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jane creation_date: 2010-08-20T01:13:35Z [Term] id: GO:2000055 name: positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] synonym: "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] synonym: "positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] is_a: GO:0030177 ! positive regulation of Wnt signaling pathway is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification relationship: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification created_by: jane creation_date: 2010-08-20T01:13:40Z [Term] id: GO:2000056 name: regulation of Wnt signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol] synonym: "regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis relationship: regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis created_by: jane creation_date: 2010-08-20T01:17:27Z [Term] id: GO:2000057 name: negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol] synonym: "negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" EXACT [GOC:signaling] is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000056 ! regulation of Wnt signaling pathway involved in digestive tract morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis relationship: negatively_regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis created_by: jane creation_date: 2010-08-20T01:17:35Z [Term] id: GO:2000058 name: regulation of ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol] synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol] synonym: "regulation of protein degradation tagging activity" RELATED [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol] synonym: "regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: regulates GO:0006511 ! ubiquitin-dependent protein catabolic process created_by: jane creation_date: 2010-08-20T01:23:46Z [Term] id: GO:2000059 name: negative regulation of ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process" [GOC:BHF] synonym: "negative regulation of protein degradation tagging activity" BROAD [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process created_by: jane creation_date: 2010-08-20T01:23:56Z [Term] id: GO:2000060 name: positive regulation of ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] synonym: "positive regulation of protein degradation tagging activity" RELATED [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process created_by: jane creation_date: 2010-08-20T01:24:03Z [Term] id: GO:2000061 name: regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051150 ! regulation of smooth muscle cell differentiation is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072193 ! ureter smooth muscle cell differentiation relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation created_by: jane creation_date: 2010-08-20T01:44:16Z [Term] id: GO:2000062 name: negative regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905900 ! negative regulation of smooth muscle tissue development is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation created_by: jane creation_date: 2010-08-20T01:44:23Z [Term] id: GO:2000063 name: positive regulation of ureter smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905901 ! positive regulation of smooth muscle tissue development is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation created_by: jane creation_date: 2010-08-20T01:44:28Z [Term] id: GO:2000064 name: regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] synonym: "regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "regulation of cortisol formation" EXACT [GOC:obol] synonym: "regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034651 ! cortisol biosynthetic process relationship: regulates GO:0034651 ! cortisol biosynthetic process created_by: jane creation_date: 2010-08-20T01:51:15Z [Term] id: GO:2000065 name: negative regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] synonym: "negative regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "negative regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cortisol formation" EXACT [GOC:obol] synonym: "negative regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0031947 ! negative regulation of glucocorticoid biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process is_a: GO:2000064 ! regulation of cortisol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034651 ! cortisol biosynthetic process relationship: negatively_regulates GO:0034651 ! cortisol biosynthetic process created_by: jane creation_date: 2010-08-20T01:51:23Z [Term] id: GO:2000066 name: positive regulation of cortisol biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] synonym: "positive regulation of cortisol anabolism" RELATED [GOC:obol] synonym: "positive regulation of cortisol biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cortisol formation" EXACT [GOC:obol] synonym: "positive regulation of cortisol synthesis" EXACT [GOC:obol] is_a: GO:0031948 ! positive regulation of glucocorticoid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process is_a: GO:2000064 ! regulation of cortisol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034651 ! cortisol biosynthetic process relationship: positively_regulates GO:0034651 ! cortisol biosynthetic process created_by: jane creation_date: 2010-08-20T01:51:32Z [Term] id: GO:2000067 name: regulation of root morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of root morphogenesis." [GOC:obol] is_a: GO:1905421 ! regulation of plant organ morphogenesis is_a: GO:2000280 ! regulation of root development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010015 ! root morphogenesis relationship: regulates GO:0010015 ! root morphogenesis created_by: tanyaberardini creation_date: 2010-08-23T09:25:13Z [Term] id: GO:2000068 name: regulation of defense response to insect namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002213 ! defense response to insect relationship: regulates GO:0002213 ! defense response to insect created_by: tanyaberardini creation_date: 2010-08-23T09:30:00Z [Term] id: GO:2000069 name: regulation of post-embryonic root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000280 ! regulation of root development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048528 ! post-embryonic root development relationship: regulates GO:0048528 ! post-embryonic root development created_by: tanyaberardini creation_date: 2010-08-23T11:31:32Z [Term] id: GO:2000070 name: regulation of response to water deprivation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol] synonym: "regulation of drought tolerance" RELATED [GOC:obol] synonym: "regulation of response to dehydration" EXACT [GOC:obol] synonym: "regulation of response to drought" EXACT [GOC:obol] synonym: "regulation of response to thirst" EXACT [GOC:obol] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009414 ! response to water deprivation relationship: regulates GO:0009414 ! response to water deprivation created_by: tanyaberardini creation_date: 2010-08-23T11:32:32Z [Term] id: GO:2000071 name: regulation of defense response by callose deposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol] synonym: "regulation of callose deposition during defense response" RELATED [GOC:obol] synonym: "regulation of callose localization during defense response" RELATED [GOC:obol] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032879 ! regulation of localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052542 ! defense response by callose deposition relationship: regulates GO:0052542 ! defense response by callose deposition created_by: tanyaberardini creation_date: 2010-08-23T11:34:01Z [Term] id: GO:2000072 name: regulation of defense response to fungus, incompatible interaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to fungus, incompatible interaction." [GOC:obol] synonym: "regulation of defence response to fungus, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defence response to pathogenic fungi, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defence response to pathogenic fungus, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of defense response to fungi, incompatible interaction" EXACT [GOC:obol] synonym: "regulation of resistance response to pathogenic fungi" EXACT [GOC:obol] synonym: "regulation of resistance response to pathogenic fungus" EXACT [GOC:obol] synonym: "regulation of response to pathogenic fungi (incompatible interaction)" EXACT [GOC:obol] synonym: "regulation of response to pathogenic fungus (incompatible interaction)" EXACT [GOC:obol] is_a: GO:0045088 ! regulation of innate immune response is_a: GO:1900150 ! regulation of defense response to fungus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009817 ! defense response to fungus, incompatible interaction relationship: regulates GO:0009817 ! defense response to fungus, incompatible interaction created_by: tanyaberardini creation_date: 2010-08-23T11:34:52Z [Term] id: GO:2000073 name: regulation of cytokinesis, site selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] synonym: "regulation of site selection involved in cell cycle cytokinesis" EXACT [] is_a: GO:0032954 ! regulation of cytokinetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007105 ! cytokinesis, site selection relationship: regulates GO:0007105 ! cytokinesis, site selection created_by: tanyaberardini creation_date: 2010-08-27T11:15:15Z [Term] id: GO:2000074 name: regulation of type B pancreatic cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003323 ! type B pancreatic cell development relationship: regulates GO:0003323 ! type B pancreatic cell development created_by: tanyaberardini creation_date: 2010-08-27T11:19:37Z [Term] id: GO:2000075 name: negative regulation of cytokinesis, site selection namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] synonym: "negative regulation of site selection involved in cell cycle cytokinesis" EXACT [] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:2000073 ! regulation of cytokinesis, site selection intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007105 ! cytokinesis, site selection relationship: negatively_regulates GO:0007105 ! cytokinesis, site selection created_by: tanyaberardini creation_date: 2010-08-27T11:19:56Z [Term] id: GO:2000076 name: positive regulation cytokinesis, site selection namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] synonym: "positive regulation of site selection involved in cell cycle cytokinesis" EXACT [] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:2000073 ! regulation of cytokinesis, site selection intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007105 ! cytokinesis, site selection relationship: positively_regulates GO:0007105 ! cytokinesis, site selection created_by: tanyaberardini creation_date: 2010-08-27T11:19:58Z [Term] id: GO:2000077 name: negative regulation of type B pancreatic cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003323 ! type B pancreatic cell development relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development created_by: tanyaberardini creation_date: 2010-08-27T11:21:17Z [Term] id: GO:2000078 name: positive regulation of type B pancreatic cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000074 ! regulation of type B pancreatic cell development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003323 ! type B pancreatic cell development relationship: positively_regulates GO:0003323 ! type B pancreatic cell development created_by: tanyaberardini creation_date: 2010-08-27T11:21:19Z [Term] id: GO:2000079 name: regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] synonym: "regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] synonym: "regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation relationship: regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation created_by: tanyaberardini creation_date: 2010-08-27T11:22:56Z [Term] id: GO:2000080 name: negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation relationship: negatively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation created_by: tanyaberardini creation_date: 2010-08-27T11:22:58Z [Term] id: GO:2000081 name: positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation relationship: positively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation created_by: tanyaberardini creation_date: 2010-08-27T11:23:00Z [Term] id: GO:2000082 name: regulation of L-ascorbic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] synonym: "regulation of ascorbate biosynthesis" EXACT [GOC:obol] synonym: "regulation of ascorbate biosynthetic process" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid formation" EXACT [GOC:obol] synonym: "regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] synonym: "regulation of vitamin C biosynthesis" EXACT [GOC:obol] synonym: "regulation of vitamin C biosynthetic process" EXACT [GOC:obol] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019853 ! L-ascorbic acid biosynthetic process relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process created_by: tanyaberardini creation_date: 2010-08-27T11:26:16Z [Term] id: GO:2000083 name: negative regulation of L-ascorbic acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] synonym: "negative regulation of ascorbate biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of ascorbate biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid formation" EXACT [GOC:obol] synonym: "negative regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of vitamin C biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process relationship: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process created_by: tanyaberardini creation_date: 2010-08-27T11:26:19Z [Term] id: GO:2000084 name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:2000027 ! regulation of animal organ morphogenesis is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis created_by: dph creation_date: 2010-09-03T06:06:41Z [Term] id: GO:2000085 name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis created_by: dph creation_date: 2010-09-03T06:08:21Z [Term] id: GO:2000086 name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis created_by: dph creation_date: 2010-09-03T06:08:24Z [Term] id: GO:2000087 name: regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0090192 ! regulation of glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061224 ! mesonephric glomerulus development relationship: regulates GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-09-03T06:09:19Z [Term] id: GO:2000088 name: negative regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0090194 ! negative regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061224 ! mesonephric glomerulus development relationship: negatively_regulates GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-09-03T06:09:22Z [Term] id: GO:2000089 name: positive regulation of mesonephric glomerulus development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0090193 ! positive regulation of glomerulus development is_a: GO:2000087 ! regulation of mesonephric glomerulus development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061224 ! mesonephric glomerulus development relationship: positively_regulates GO:0061224 ! mesonephric glomerulus development created_by: dph creation_date: 2010-09-03T06:09:24Z [Term] id: GO:2000090 name: regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation is_a: GO:2000087 ! regulation of mesonephric glomerulus development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development relationship: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development created_by: dph creation_date: 2010-09-03T06:10:28Z [Term] id: GO:2000091 name: negative regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation is_a: GO:2000088 ! negative regulation of mesonephric glomerulus development is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation is_a: GO:2000607 ! negative regulation of cell proliferation involved in mesonephros development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development relationship: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development created_by: dph creation_date: 2010-09-03T06:10:31Z [Term] id: GO:2000092 name: positive regulation of mesonephric glomerular mesangial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation is_a: GO:2000089 ! positive regulation of mesonephric glomerulus development is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation is_a: GO:2000608 ! positive regulation of cell proliferation involved in mesonephros development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development relationship: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development created_by: dph creation_date: 2010-09-03T06:10:33Z [Term] id: GO:2000093 name: regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation relationship: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation created_by: dph creation_date: 2010-09-03T06:12:25Z [Term] id: GO:2000094 name: negative regulation of mesonephric nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation relationship: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation created_by: dph creation_date: 2010-09-03T06:12:28Z [Term] id: GO:2000095 name: regulation of Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "regulation of PCP pathway" EXACT [GOC:obol] synonym: "regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:0090175 ! regulation of establishment of planar polarity is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway created_by: jane creation_date: 2010-09-08T01:07:39Z [Term] id: GO:2000096 name: positive regulation of Wnt signaling pathway, planar cell polarity pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of PCP pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] synonym: "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway created_by: jane creation_date: 2010-09-08T01:07:42Z [Term] id: GO:2000097 name: regulation of smooth muscle cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] is_a: GO:0001952 ! regulation of cell-matrix adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061302 ! smooth muscle cell-matrix adhesion relationship: regulates GO:0061302 ! smooth muscle cell-matrix adhesion created_by: dph creation_date: 2010-09-14T04:22:20Z [Term] id: GO:2000098 name: negative regulation of smooth muscle cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] is_a: GO:0001953 ! negative regulation of cell-matrix adhesion is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion relationship: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion created_by: dph creation_date: 2010-09-14T04:22:22Z [Term] id: GO:2000099 name: regulation of establishment or maintenance of bipolar cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity created_by: dph creation_date: 2010-09-14T04:40:51Z [Term] id: GO:2000100 name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] is_a: GO:2000099 ! regulation of establishment or maintenance of bipolar cell polarity is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape relationship: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-09-14T04:44:57Z [Term] id: GO:2000101 name: regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002174 ! mammary stem cell proliferation relationship: regulates GO:0002174 ! mammary stem cell proliferation created_by: dph creation_date: 2010-09-14T06:10:32Z [Term] id: GO:2000102 name: negative regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000101 ! regulation of mammary stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002174 ! mammary stem cell proliferation relationship: negatively_regulates GO:0002174 ! mammary stem cell proliferation created_by: dph creation_date: 2010-09-14T06:10:34Z [Term] id: GO:2000103 name: positive regulation of mammary stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000101 ! regulation of mammary stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002174 ! mammary stem cell proliferation relationship: positively_regulates GO:0002174 ! mammary stem cell proliferation created_by: dph creation_date: 2010-09-14T06:10:36Z [Term] id: GO:2000104 name: negative regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] is_a: GO:0008156 ! negative regulation of DNA replication is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006261 ! DNA-dependent DNA replication relationship: negatively_regulates GO:0006261 ! DNA-dependent DNA replication created_by: midori creation_date: 2010-09-15T01:37:05Z [Term] id: GO:2000105 name: positive regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] is_a: GO:0045740 ! positive regulation of DNA replication is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006261 ! DNA-dependent DNA replication relationship: positively_regulates GO:0006261 ! DNA-dependent DNA replication created_by: midori creation_date: 2010-09-15T01:37:10Z [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of leukocyte apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071887 ! leukocyte apoptotic process relationship: regulates GO:0071887 ! leukocyte apoptotic process created_by: midori creation_date: 2010-09-15T01:42:05Z [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071887 ! leukocyte apoptotic process relationship: negatively_regulates GO:0071887 ! leukocyte apoptotic process created_by: midori creation_date: 2010-09-15T01:42:09Z [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071887 ! leukocyte apoptotic process relationship: positively_regulates GO:0071887 ! leukocyte apoptotic process created_by: midori creation_date: 2010-09-15T01:42:12Z [Term] id: GO:2000109 name: regulation of macrophage apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "regulation of AICD" RELATED [GOC:yaf] synonym: "regulation of macrophage apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071888 ! macrophage apoptotic process relationship: regulates GO:0071888 ! macrophage apoptotic process created_by: midori creation_date: 2010-09-15T01:44:15Z [Term] id: GO:2000110 name: negative regulation of macrophage apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "negative regulation of AICD" RELATED [GOC:yaf] synonym: "negative regulation of macrophage apoptosis" NARROW [] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071888 ! macrophage apoptotic process relationship: negatively_regulates GO:0071888 ! macrophage apoptotic process created_by: midori creation_date: 2010-09-15T01:44:18Z [Term] id: GO:2000111 name: positive regulation of macrophage apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "positive regulation of AICD" RELATED [GOC:yaf] synonym: "positive regulation of macrophage apoptosis" NARROW [] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071888 ! macrophage apoptotic process relationship: positively_regulates GO:0071888 ! macrophage apoptotic process created_by: midori creation_date: 2010-09-15T01:44:21Z [Term] id: GO:2000112 name: regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tanyaberardini creation_date: 2010-09-15T08:55:45Z [Term] id: GO:2000113 name: negative regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process created_by: tanyaberardini creation_date: 2010-09-15T08:55:48Z [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030010 ! establishment of cell polarity relationship: regulates GO:0030010 ! establishment of cell polarity created_by: dph creation_date: 2010-09-16T01:22:36Z [Term] id: GO:2000115 name: regulation of maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol] is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape relationship: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape created_by: dph creation_date: 2010-09-21T06:33:26Z [Term] id: GO:2000116 name: regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0052548 ! regulation of endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004197 ! cysteine-type endopeptidase activity relationship: regulates GO:0004197 ! cysteine-type endopeptidase activity created_by: jane creation_date: 2010-09-23T10:24:33Z [Term] id: GO:2000117 name: negative regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0010951 ! negative regulation of endopeptidase activity is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity relationship: negatively_regulates GO:0004197 ! cysteine-type endopeptidase activity created_by: jane creation_date: 2010-09-23T10:24:35Z [Term] id: GO:2000118 name: regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:0010966 ! regulation of phosphate transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044341 ! sodium-dependent phosphate transport relationship: regulates GO:0044341 ! sodium-dependent phosphate transport created_by: jane creation_date: 2010-09-23T01:34:59Z [Term] id: GO:2000119 name: negative regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport relationship: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport created_by: jane creation_date: 2010-09-23T01:35:03Z [Term] id: GO:2000120 name: positive regulation of sodium-dependent phosphate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044341 ! sodium-dependent phosphate transport relationship: positively_regulates GO:0044341 ! sodium-dependent phosphate transport created_by: jane creation_date: 2010-09-23T01:35:06Z [Term] id: GO:2000121 name: regulation of removal of superoxide radicals namespace: biological_process def: "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol] synonym: "regulation of removal of O2-" EXACT [GOC:obol] synonym: "regulation of removal of oxygen free radicals" EXACT [GOC:obol] is_a: GO:0090322 ! regulation of superoxide metabolic process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1901031 ! regulation of response to reactive oxygen species intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019430 ! removal of superoxide radicals relationship: regulates GO:0019430 ! removal of superoxide radicals created_by: dhl creation_date: 2010-09-27T05:30:37Z [Term] id: GO:2000122 name: negative regulation of stomatal complex development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000038 ! regulation of stomatal complex development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010374 ! stomatal complex development relationship: negatively_regulates GO:0010374 ! stomatal complex development created_by: dhl creation_date: 2010-09-27T08:28:26Z [Term] id: GO:2000123 name: positive regulation of stomatal complex development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000038 ! regulation of stomatal complex development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010374 ! stomatal complex development relationship: positively_regulates GO:0010374 ! stomatal complex development created_by: dhl creation_date: 2010-09-27T08:28:28Z [Term] id: GO:2000124 name: regulation of endocannabinoid signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444] synonym: "regulation of endocannabinoid signalling pathway" EXACT [GOC:obol] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071926 ! endocannabinoid signaling pathway relationship: regulates GO:0071926 ! endocannabinoid signaling pathway created_by: midori creation_date: 2010-09-29T09:05:43Z [Term] id: GO:2000125 name: regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007211 ! octopamine or tyramine signaling pathway relationship: regulates GO:0007211 ! octopamine or tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:27:12Z [Term] id: GO:2000126 name: negative regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "negative regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "negative regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway relationship: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:27:16Z [Term] id: GO:2000127 name: positive regulation of octopamine or tyramine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] synonym: "positive regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] synonym: "positive regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway relationship: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:27:19Z [Term] id: GO:2000128 name: regulation of octopamine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071927 ! octopamine signaling pathway relationship: regulates GO:0071927 ! octopamine signaling pathway created_by: midori creation_date: 2010-09-29T09:29:41Z [Term] id: GO:2000129 name: negative regulation of octopamine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "negative regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway is_a: GO:2000128 ! regulation of octopamine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071927 ! octopamine signaling pathway relationship: negatively_regulates GO:0071927 ! octopamine signaling pathway created_by: midori creation_date: 2010-09-29T09:29:44Z [Term] id: GO:2000130 name: positive regulation of octopamine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] synonym: "positive regulation of octopamine signalling pathway" EXACT [GOC:obol] is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway is_a: GO:2000128 ! regulation of octopamine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071927 ! octopamine signaling pathway relationship: positively_regulates GO:0071927 ! octopamine signaling pathway created_by: midori creation_date: 2010-09-29T09:29:47Z [Term] id: GO:2000131 name: regulation of tyramine signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071928 ! tyramine signaling pathway relationship: regulates GO:0071928 ! tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:31:56Z [Term] id: GO:2000132 name: negative regulation of tyramine signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "negative regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway is_a: GO:2000131 ! regulation of tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071928 ! tyramine signaling pathway relationship: negatively_regulates GO:0071928 ! tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:32:00Z [Term] id: GO:2000133 name: positive regulation of tyramine signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] synonym: "positive regulation of tyramine signalling pathway" EXACT [GOC:obol] is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway is_a: GO:2000131 ! regulation of tyramine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071928 ! tyramine signaling pathway relationship: positively_regulates GO:0071928 ! tyramine signaling pathway created_by: midori creation_date: 2010-09-29T09:32:03Z [Term] id: GO:2000134 name: negative regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2010-09-29T09:38:51Z [Term] id: GO:2000135 name: obsolete positive regulation of regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph] comment: This term was made obsolete because it makes no sense and was added in error. synonym: "positive regulation of regulation of second heart field cardioblast proliferation" EXACT [GOC:obol] synonym: "positive regulation of regulation of secondary heart field cardioblast proliferation" EXACT [] is_obsolete: true created_by: dph creation_date: 2010-09-29T12:40:37Z [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:53Z [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:55Z [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis created_by: dph creation_date: 2010-09-29T12:43:57Z [Term] id: GO:2000139 name: regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032095 ! regulation of response to food is_a: GO:2000128 ! regulation of octopamine signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071935 ! octopamine signaling pathway involved in response to food relationship: regulates GO:0071935 ! octopamine signaling pathway involved in response to food created_by: midori creation_date: 2010-09-30T02:48:07Z [Term] id: GO:2000140 name: negative regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "negative regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032096 ! negative regulation of response to food is_a: GO:2000129 ! negative regulation of octopamine signaling pathway is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food relationship: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food created_by: midori creation_date: 2010-09-30T02:48:10Z [Term] id: GO:2000141 name: positive regulation of octopamine signaling pathway involved in response to food namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] synonym: "positive regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] is_a: GO:0032097 ! positive regulation of response to food is_a: GO:2000130 ! positive regulation of octopamine signaling pathway is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food relationship: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food created_by: midori creation_date: 2010-09-30T02:48:12Z [Term] id: GO:2000142 name: regulation of DNA-templated transcription, initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] synonym: "regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006352 ! DNA-templated transcription, initiation relationship: regulates GO:0006352 ! DNA-templated transcription, initiation created_by: midori creation_date: 2010-10-01T09:11:35Z [Term] id: GO:2000143 name: negative regulation of DNA-templated transcription, initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] synonym: "negative regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "negative regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "negative regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006352 ! DNA-templated transcription, initiation relationship: negatively_regulates GO:0006352 ! DNA-templated transcription, initiation created_by: midori creation_date: 2010-10-01T09:11:40Z [Term] id: GO:2000144 name: positive regulation of DNA-templated transcription, initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] synonym: "positive regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "positive regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "positive regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] synonym: "transactivation" RELATED [PMID:11158542] synonym: "transcriptional transactivation" RELATED [PMID:11580863] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006352 ! DNA-templated transcription, initiation relationship: positively_regulates GO:0006352 ! DNA-templated transcription, initiation created_by: midori creation_date: 2010-10-01T09:11:43Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048870 ! cell motility relationship: regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048870 ! cell motility relationship: negatively_regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048870 ! cell motility relationship: positively_regulates GO:0048870 ! cell motility created_by: midori creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000148 name: regulation of planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis is_a: GO:1904412 ! regulation of cardiac ventricle development is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis relationship: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis created_by: dph creation_date: 2010-10-01T07:09:49Z [Term] id: GO:2000149 name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis is_a: GO:1904413 ! negative regulation of cardiac ventricle development is_a: GO:2000148 ! regulation of planar cell polarity pathway involved in ventricular septum morphogenesis is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis relationship: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis created_by: dph creation_date: 2010-10-01T07:09:53Z [Term] id: GO:2000150 name: regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis relationship: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis created_by: dph creation_date: 2010-10-01T07:11:11Z [Term] id: GO:2000151 name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development is_a: GO:2000150 ! regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis relationship: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis created_by: dph creation_date: 2010-10-01T07:11:15Z [Term] id: GO:2000152 name: regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol] synonym: "regulation of deubiquitinase activity" EXACT [] synonym: "regulation of UBP" RELATED [GOC:obol] synonym: "regulation of UCH2" RELATED [GOC:obol] is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity relationship: regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity created_by: tanyaberardini creation_date: 2010-10-01T10:09:28Z [Term] id: GO:2000153 name: obsolete regulation of flagellar cell motility namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "regulation of flagellar cell motility" EXACT [] is_obsolete: true consider: GO:1902019 consider: GO:1902021 created_by: midori creation_date: 2010-10-04T12:41:02Z [Term] id: GO:2000154 name: obsolete negative regulation of flagellar cell motility namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "negative regulation of flagellar cell motility" EXACT [] is_obsolete: true consider: GO:1902020 consider: GO:1902201 created_by: midori creation_date: 2010-10-04T12:41:04Z [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] synonym: "positive regulation of ciliary cell motility" RELATED [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060285 ! cilium-dependent cell motility relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility created_by: midori creation_date: 2010-10-04T12:41:05Z [Term] id: GO:2000156 name: regulation of retrograde vesicle-mediated transport, Golgi to ER namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah] synonym: "regulation of cis-Golgi to rough endoplasmic reticulum transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough ER transport" EXACT [GOC:obol] synonym: "regulation of cis-Golgi to rough ER vesicle-mediated transport" EXACT [GOC:obol] synonym: "regulation of retrograde (Golgi to ER) transport" EXACT [GOC:obol] synonym: "regulation of retrograde transport, Golgi to endoplasmic reticulum" EXACT [GOC:obol] synonym: "regulation of retrograde transport, Golgi to ER" EXACT [GOC:obol] synonym: "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [GOC:obol] is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum relationship: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum created_by: midori creation_date: 2010-10-04T12:46:35Z [Term] id: GO:2000157 name: negative regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] synonym: "negative regulation of deubiquitinase activity" EXACT [] synonym: "negative regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] synonym: "negative regulation of UBP" RELATED [GOC:obol] synonym: "negative regulation of UCH2" RELATED [GOC:obol] is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity relationship: negatively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity created_by: tanyaberardini creation_date: 2010-10-04T10:42:27Z [Term] id: GO:2000158 name: positive regulation of ubiquitin-specific protease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] synonym: "positive regulation of deubiquitinase activity" EXACT [] synonym: "positive regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] synonym: "positive regulation of UBP" RELATED [GOC:obol] synonym: "positive regulation of UCH2" RELATED [GOC:obol] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity relationship: positively_regulates GO:0004843 ! thiol-dependent ubiquitin-specific protease activity created_by: tanyaberardini creation_date: 2010-10-04T10:42:29Z [Term] id: GO:2000159 name: regulation of planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis created_by: dph creation_date: 2010-10-05T01:03:22Z [Term] id: GO:2000160 name: negative regulation of planar cell polarity pathway involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis relationship: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis created_by: dph creation_date: 2010-10-05T01:03:25Z [Term] id: GO:2000161 name: regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis relationship: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis created_by: dph creation_date: 2010-10-05T01:05:21Z [Term] id: GO:2000162 name: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] is_a: GO:1901220 ! negative regulation of cardiac chamber morphogenesis is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000161 ! regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis relationship: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis created_by: dph creation_date: 2010-10-05T01:05:24Z [Term] id: GO:2000163 name: regulation of planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis relationship: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis created_by: dph creation_date: 2010-10-05T01:06:13Z [Term] id: GO:2000164 name: negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000163 ! regulation of planar cell polarity pathway involved in outflow tract morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis relationship: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis created_by: dph creation_date: 2010-10-05T01:06:15Z [Term] id: GO:2000165 name: regulation of planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis relationship: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis created_by: dph creation_date: 2010-10-05T01:07:36Z [Term] id: GO:2000166 name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis is_a: GO:2000165 ! regulation of planar cell polarity pathway involved in pericardium morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis relationship: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis created_by: dph creation_date: 2010-10-05T01:07:39Z [Term] id: GO:2000167 name: regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure relationship: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure created_by: dph creation_date: 2010-10-05T01:08:53Z [Term] id: GO:2000168 name: negative regulation of planar cell polarity pathway involved in neural tube closure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:1905277 ! negative regulation of epithelial tube formation is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway is_a: GO:2000167 ! regulation of planar cell polarity pathway involved in neural tube closure intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure relationship: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure created_by: dph creation_date: 2010-10-05T01:08:56Z [Term] id: GO:2000169 name: regulation of peptidyl-cysteine S-nitrosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation relationship: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation created_by: rl creation_date: 2010-10-07T10:49:32Z [Term] id: GO:2000170 name: positive regulation of peptidyl-cysteine S-nitrosylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation relationship: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation created_by: rl creation_date: 2010-10-07T10:49:35Z [Term] id: GO:2000171 name: negative regulation of dendrite development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016358 ! dendrite development relationship: negatively_regulates GO:0016358 ! dendrite development created_by: rl creation_date: 2010-10-07T10:53:15Z [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048755 ! branching morphogenesis of a nerve relationship: regulates GO:0048755 ! branching morphogenesis of a nerve created_by: rl creation_date: 2010-10-07T12:07:54Z [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve created_by: rl creation_date: 2010-10-07T12:07:56Z [Term] id: GO:2000174 name: regulation of pro-T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002572 ! pro-T cell differentiation relationship: regulates GO:0002572 ! pro-T cell differentiation created_by: midori creation_date: 2010-10-11T10:24:30Z [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002572 ! pro-T cell differentiation relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation created_by: midori creation_date: 2010-10-11T10:24:33Z [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002572 ! pro-T cell differentiation relationship: positively_regulates GO:0002572 ! pro-T cell differentiation created_by: midori creation_date: 2010-10-11T10:24:35Z [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061351 ! neural precursor cell proliferation relationship: regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:41Z [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061351 ! neural precursor cell proliferation relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:43Z [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061351 ! neural precursor cell proliferation relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation created_by: dph creation_date: 2010-10-13T12:40:45Z [Term] id: GO:2000180 name: negative regulation of androgen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph, GOC:yaf] synonym: "negative regulation of androgen anabolism" EXACT [GOC:obol] synonym: "negative regulation of androgen biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of androgen formation" EXACT [GOC:obol] synonym: "negative regulation of androgen synthesis" EXACT [GOC:obol] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006702 ! androgen biosynthetic process relationship: negatively_regulates GO:0006702 ! androgen biosynthetic process created_by: dph creation_date: 2010-10-13T12:43:17Z [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048514 ! blood vessel morphogenesis relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2010-10-13T12:46:31Z [Term] id: GO:2000182 name: regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "regulation of progesterone formation" EXACT [GOC:obol] synonym: "regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006701 ! progesterone biosynthetic process relationship: regulates GO:0006701 ! progesterone biosynthetic process created_by: dph creation_date: 2010-10-14T07:36:06Z [Term] id: GO:2000183 name: negative regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of progesterone formation" EXACT [GOC:obol] synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006701 ! progesterone biosynthetic process relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process created_by: dph creation_date: 2010-10-14T07:36:10Z [Term] id: GO:2000184 name: positive regulation of progesterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol] synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of progesterone formation" EXACT [GOC:obol] synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:2000182 ! regulation of progesterone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006701 ! progesterone biosynthetic process relationship: positively_regulates GO:0006701 ! progesterone biosynthetic process created_by: dph creation_date: 2010-10-14T07:36:14Z [Term] id: GO:2000185 name: regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "regulation of phosphate membrane transport" EXACT [] is_a: GO:0010966 ! regulation of phosphate transport is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035435 ! phosphate ion transmembrane transport relationship: regulates GO:0035435 ! phosphate ion transmembrane transport created_by: vw creation_date: 2010-10-15T11:33:04Z [Term] id: GO:2000186 name: negative regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "negative regulation of phosphate membrane transport" EXACT [] is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport created_by: vw creation_date: 2010-10-15T11:33:08Z [Term] id: GO:2000187 name: positive regulation of phosphate transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] synonym: "positive regulation of phosphate membrane transport" EXACT [] is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport is_a: GO:2000185 ! regulation of phosphate transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035435 ! phosphate ion transmembrane transport relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport created_by: vw creation_date: 2010-10-15T11:33:10Z [Term] id: GO:2000190 name: obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF] comment: This term was made obsolete because it makes no sense and was added in error. synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] is_obsolete: true consider: GO:0000122 consider: GO:0004879 consider: GO:0030374 consider: GO:0030522 created_by: rl creation_date: 2010-10-18T10:02:57Z [Term] id: GO:2000191 name: regulation of fatty acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015908 ! fatty acid transport relationship: regulates GO:0015908 ! fatty acid transport created_by: rl creation_date: 2010-10-18T10:37:13Z [Term] id: GO:2000192 name: negative regulation of fatty acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015908 ! fatty acid transport relationship: negatively_regulates GO:0015908 ! fatty acid transport created_by: rl creation_date: 2010-10-18T10:37:15Z [Term] id: GO:2000193 name: positive regulation of fatty acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:2000191 ! regulation of fatty acid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015908 ! fatty acid transport relationship: positively_regulates GO:0015908 ! fatty acid transport created_by: rl creation_date: 2010-10-18T10:37:17Z [Term] id: GO:2000194 name: regulation of female gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "regulation of ovarian development" EXACT [GOC:obol] synonym: "regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008585 ! female gonad development relationship: regulates GO:0008585 ! female gonad development created_by: yaf creation_date: 2010-10-19T10:45:34Z [Term] id: GO:2000195 name: negative regulation of female gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "negative regulation of ovarian development" EXACT [GOC:obol] synonym: "negative regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008585 ! female gonad development relationship: negatively_regulates GO:0008585 ! female gonad development created_by: yaf creation_date: 2010-10-19T10:45:38Z [Term] id: GO:2000196 name: positive regulation of female gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "positive regulation of ovarian development" EXACT [GOC:obol] synonym: "positive regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008585 ! female gonad development relationship: positively_regulates GO:0008585 ! female gonad development created_by: yaf creation_date: 2010-10-19T10:45:41Z [Term] id: GO:2000197 name: regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071166 ! ribonucleoprotein complex localization relationship: regulates GO:0071166 ! ribonucleoprotein complex localization created_by: midori creation_date: 2010-10-26T10:35:48Z [Term] id: GO:2000198 name: negative regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "negative regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization relationship: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization created_by: midori creation_date: 2010-10-26T10:35:52Z [Term] id: GO:2000199 name: positive regulation of ribonucleoprotein complex localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "positive regulation of RNP localization" EXACT [GOC:obol] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071166 ! ribonucleoprotein complex localization relationship: positively_regulates GO:0071166 ! ribonucleoprotein complex localization created_by: midori creation_date: 2010-10-26T10:35:55Z [Term] id: GO:2000200 name: regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0046831 ! regulation of RNA export from nucleus is_a: GO:0090069 ! regulation of ribosome biogenesis is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000054 ! ribosomal subunit export from nucleus relationship: regulates GO:0000054 ! ribosomal subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:44:27Z [Term] id: GO:2000201 name: negative regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "negative regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "negative regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046826 ! negative regulation of protein export from nucleus is_a: GO:0046832 ! negative regulation of RNA export from nucleus is_a: GO:0090071 ! negative regulation of ribosome biogenesis is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus relationship: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:44:32Z [Term] id: GO:2000202 name: positive regulation of ribosomal subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] synonym: "positive regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] synonym: "positive regulation of ribosome export from nucleus" RELATED [GOC:obol] is_a: GO:0046827 ! positive regulation of protein export from nucleus is_a: GO:0046833 ! positive regulation of RNA export from nucleus is_a: GO:0090070 ! positive regulation of ribosome biogenesis is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus relationship: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:44:36Z [Term] id: GO:2000203 name: regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000055 ! ribosomal large subunit export from nucleus relationship: regulates GO:0000055 ! ribosomal large subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:52:36Z [Term] id: GO:2000204 name: negative regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "negative regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus relationship: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:52:39Z [Term] id: GO:2000205 name: positive regulation of ribosomal large subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] synonym: "positive regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus relationship: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:52:42Z [Term] id: GO:2000206 name: regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000056 ! ribosomal small subunit export from nucleus relationship: regulates GO:0000056 ! ribosomal small subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:54:09Z [Term] id: GO:2000207 name: negative regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "negative regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "negative regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus relationship: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:54:14Z [Term] id: GO:2000208 name: positive regulation of ribosomal small subunit export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] synonym: "positive regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] synonym: "positive regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus relationship: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus created_by: midori creation_date: 2010-10-26T10:54:16Z [Term] id: GO:2000209 name: regulation of anoikis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah] synonym: "regulation of detachment induced cell death" EXACT [GOC:obol] synonym: "regulation of suspension induced apoptosis" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043276 ! anoikis relationship: regulates GO:0043276 ! anoikis created_by: midori creation_date: 2010-11-03T02:00:33Z [Term] id: GO:2000210 name: positive regulation of anoikis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anoikis." [GOC:mah] synonym: "positive regulation of detachment induced cell death" EXACT [GOC:obol] synonym: "positive regulation of suspension induced apoptosis" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000209 ! regulation of anoikis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043276 ! anoikis relationship: positively_regulates GO:0043276 ! anoikis created_by: midori creation_date: 2010-11-03T02:00:36Z [Term] id: GO:2000211 name: regulation of glutamate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006536 ! glutamate metabolic process relationship: regulates GO:0006536 ! glutamate metabolic process created_by: midori creation_date: 2010-11-03T02:43:51Z [Term] id: GO:2000212 name: negative regulation of glutamate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006536 ! glutamate metabolic process relationship: negatively_regulates GO:0006536 ! glutamate metabolic process created_by: midori creation_date: 2010-11-03T02:43:55Z [Term] id: GO:2000213 name: positive regulation of glutamate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006536 ! glutamate metabolic process relationship: positively_regulates GO:0006536 ! glutamate metabolic process created_by: midori creation_date: 2010-11-03T02:43:59Z [Term] id: GO:2000214 name: regulation of proline metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006560 ! proline metabolic process relationship: regulates GO:0006560 ! proline metabolic process created_by: midori creation_date: 2010-11-03T02:45:20Z [Term] id: GO:2000215 name: negative regulation of proline metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "negative regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000214 ! regulation of proline metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006560 ! proline metabolic process relationship: negatively_regulates GO:0006560 ! proline metabolic process created_by: midori creation_date: 2010-11-03T02:45:24Z [Term] id: GO:2000216 name: positive regulation of proline metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl] synonym: "positive regulation of proline metabolism" EXACT [GOC:obol] is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000214 ! regulation of proline metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006560 ! proline metabolic process relationship: positively_regulates GO:0006560 ! proline metabolic process created_by: midori creation_date: 2010-11-03T02:45:27Z [Term] id: GO:2000217 name: regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001403 ! invasive growth in response to glucose limitation relationship: regulates GO:0001403 ! invasive growth in response to glucose limitation created_by: midori creation_date: 2010-11-03T04:35:56Z [Term] id: GO:2000218 name: negative regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "negative regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation created_by: midori creation_date: 2010-11-03T04:36:00Z [Term] id: GO:2000219 name: positive regulation of invasive growth in response to glucose limitation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] synonym: "positive regulation of colony morphology" RELATED [GOC:obol] is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation created_by: midori creation_date: 2010-11-03T04:36:02Z [Term] id: GO:2000220 name: regulation of pseudohyphal growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007124 ! pseudohyphal growth relationship: regulates GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2010-11-03T04:36:56Z [Term] id: GO:2000221 name: negative regulation of pseudohyphal growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000220 ! regulation of pseudohyphal growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007124 ! pseudohyphal growth relationship: negatively_regulates GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2010-11-03T04:37:00Z [Term] id: GO:2000222 name: positive regulation of pseudohyphal growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells is_a: GO:2000220 ! regulation of pseudohyphal growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007124 ! pseudohyphal growth relationship: positively_regulates GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2010-11-03T04:37:03Z [Term] id: GO:2000223 name: regulation of BMP signaling pathway involved in heart jogging namespace: biological_process def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF] synonym: "regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis" EXACT [GOC:mah] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0045995 ! regulation of embryonic development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging relationship: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging created_by: vk creation_date: 2010-11-04T02:44:01Z [Term] id: GO:2000224 name: regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061370 ! testosterone biosynthetic process relationship: regulates GO:0061370 ! testosterone biosynthetic process created_by: yaf creation_date: 2010-11-09T10:38:33Z [Term] id: GO:2000225 name: negative regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000224 ! regulation of testosterone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061370 ! testosterone biosynthetic process relationship: negatively_regulates GO:0061370 ! testosterone biosynthetic process created_by: yaf creation_date: 2010-11-09T10:38:37Z [Term] id: GO:2000226 name: regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003310 ! pancreatic A cell differentiation relationship: regulates GO:0003310 ! pancreatic A cell differentiation created_by: midori creation_date: 2010-11-09T03:43:37Z [Term] id: GO:2000227 name: negative regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003310 ! pancreatic A cell differentiation relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation created_by: midori creation_date: 2010-11-09T03:43:40Z [Term] id: GO:2000228 name: positive regulation of pancreatic A cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000226 ! regulation of pancreatic A cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003310 ! pancreatic A cell differentiation relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation created_by: midori creation_date: 2010-11-09T03:43:42Z [Term] id: GO:2000229 name: regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072343 ! pancreatic stellate cell proliferation relationship: regulates GO:0072343 ! pancreatic stellate cell proliferation created_by: midori creation_date: 2010-11-09T03:45:18Z [Term] id: GO:2000230 name: negative regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048147 ! negative regulation of fibroblast proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation relationship: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation created_by: midori creation_date: 2010-11-09T03:45:21Z [Term] id: GO:2000231 name: positive regulation of pancreatic stellate cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] is_a: GO:0048146 ! positive regulation of fibroblast proliferation is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation relationship: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation created_by: midori creation_date: 2010-11-09T03:45:23Z [Term] id: GO:2000232 name: regulation of rRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051252 ! regulation of RNA metabolic process is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006364 ! rRNA processing relationship: regulates GO:0006364 ! rRNA processing created_by: midori creation_date: 2010-11-10T12:11:29Z [Term] id: GO:2000233 name: negative regulation of rRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "negative regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:0090071 ! negative regulation of ribosome biogenesis is_a: GO:2000232 ! regulation of rRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006364 ! rRNA processing relationship: negatively_regulates GO:0006364 ! rRNA processing created_by: midori creation_date: 2010-11-10T12:11:33Z [Term] id: GO:2000234 name: positive regulation of rRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah] synonym: "positive regulation of 35S primary transcript processing" RELATED [GOC:obol] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:0090070 ! positive regulation of ribosome biogenesis is_a: GO:2000232 ! regulation of rRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006364 ! rRNA processing relationship: positively_regulates GO:0006364 ! rRNA processing created_by: midori creation_date: 2010-11-10T12:11:36Z [Term] id: GO:2000235 name: regulation of tRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903326 ! regulation of tRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008033 ! tRNA processing relationship: regulates GO:0008033 ! tRNA processing created_by: midori creation_date: 2010-11-10T12:15:08Z [Term] id: GO:2000236 name: negative regulation of tRNA processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "negative regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:1903327 ! negative regulation of tRNA metabolic process is_a: GO:2000235 ! regulation of tRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008033 ! tRNA processing relationship: negatively_regulates GO:0008033 ! tRNA processing created_by: midori creation_date: 2010-11-10T12:15:13Z [Term] id: GO:2000237 name: positive regulation of tRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah] synonym: "positive regulation of tRNA maturation" EXACT [GOC:obol] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1903328 ! positive regulation of tRNA metabolic process is_a: GO:2000235 ! regulation of tRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008033 ! tRNA processing relationship: positively_regulates GO:0008033 ! tRNA processing created_by: midori creation_date: 2010-11-10T12:15:17Z [Term] id: GO:2000238 name: regulation of tRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0046831 ! regulation of RNA export from nucleus is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006409 ! tRNA export from nucleus relationship: regulates GO:0006409 ! tRNA export from nucleus created_by: midori creation_date: 2010-11-10T12:39:33Z [Term] id: GO:2000239 name: negative regulation of tRNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046826 ! negative regulation of protein export from nucleus is_a: GO:0046832 ! negative regulation of RNA export from nucleus is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization is_a: GO:2000238 ! regulation of tRNA export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006409 ! tRNA export from nucleus relationship: negatively_regulates GO:0006409 ! tRNA export from nucleus created_by: midori creation_date: 2010-11-10T12:39:36Z [Term] id: GO:2000240 name: positive regulation of tRNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol] synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol] is_a: GO:0046827 ! positive regulation of protein export from nucleus is_a: GO:0046833 ! positive regulation of RNA export from nucleus is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization is_a: GO:2000238 ! regulation of tRNA export from nucleus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006409 ! tRNA export from nucleus relationship: positively_regulates GO:0006409 ! tRNA export from nucleus created_by: midori creation_date: 2010-11-10T12:39:38Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0022414 ! reproductive process relationship: regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0022414 ! reproductive process relationship: negatively_regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0022414 ! reproductive process relationship: positively_regulates GO:0022414 ! reproductive process created_by: midori creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000244 name: regulation of FtsZ-dependent cytokinesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis." [GOC:mah] synonym: "regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] synonym: "regulation of prokaryotic fission" RELATED [GOC:obol] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:1903664 ! regulation of asexual reproduction is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043093 ! FtsZ-dependent cytokinesis relationship: regulates GO:0043093 ! FtsZ-dependent cytokinesis created_by: midori creation_date: 2010-11-10T02:46:36Z [Term] id: GO:2000245 name: negative regulation of FtsZ-dependent cytokinesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah] synonym: "negative regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] synonym: "negative regulation of prokaryotic fission" RELATED [GOC:obol] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:1903665 ! negative regulation of asexual reproduction is_a: GO:2000242 ! negative regulation of reproductive process is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis relationship: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis created_by: midori creation_date: 2010-11-10T02:46:39Z [Term] id: GO:2000246 name: positive regulation of FtsZ-dependent cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah] synonym: "positive regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] synonym: "positive regulation of prokaryotic fission" RELATED [GOC:obol] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:1903666 ! positive regulation of asexual reproduction is_a: GO:2000243 ! positive regulation of reproductive process is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis relationship: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis created_by: midori creation_date: 2010-11-10T02:46:41Z [Term] id: GO:2000247 name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape relationship: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape created_by: vw creation_date: 2010-11-11T11:39:34Z [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] is_a: GO:0007406 ! negative regulation of neuroblast proliferation is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division is_a: GO:1904676 ! negative regulation of somatic stem cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity created_by: vw creation_date: 2010-11-11T11:40:34Z [Term] id: GO:2000249 name: regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031532 ! actin cytoskeleton reorganization relationship: regulates GO:0031532 ! actin cytoskeleton reorganization created_by: vk creation_date: 2010-11-11T01:25:26Z [Term] id: GO:2000250 name: negative regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "negative regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "negative regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization relationship: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization created_by: vk creation_date: 2010-11-11T01:25:29Z [Term] id: GO:2000251 name: positive regulation of actin cytoskeleton reorganization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] synonym: "positive regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] synonym: "positive regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031532 ! actin cytoskeleton reorganization relationship: positively_regulates GO:0031532 ! actin cytoskeleton reorganization created_by: vk creation_date: 2010-11-11T01:25:32Z [Term] id: GO:2000252 name: negative regulation of feeding behavior namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol] synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol] synonym: "negative regulation of drinking" RELATED [GOC:obol] synonym: "negative regulation of eating" RELATED [GOC:obol] synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048521 ! negative regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007631 ! feeding behavior relationship: negatively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:14Z [Term] id: GO:2000253 name: positive regulation of feeding behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol] synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol] synonym: "positive regulation of drinking" RELATED [GOC:obol] synonym: "positive regulation of eating" RELATED [GOC:obol] synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol] is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0060259 ! regulation of feeding behavior intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007631 ! feeding behavior relationship: positively_regulates GO:0007631 ! feeding behavior created_by: yaf creation_date: 2010-11-18T11:24:18Z [Term] id: GO:2000254 name: regulation of male germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002176 ! male germ cell proliferation relationship: regulates GO:0002176 ! male germ cell proliferation created_by: dph creation_date: 2010-11-18T09:29:44Z [Term] id: GO:2000255 name: negative regulation of male germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905937 ! negative regulation of germ cell proliferation is_a: GO:2000254 ! regulation of male germ cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002176 ! male germ cell proliferation relationship: negatively_regulates GO:0002176 ! male germ cell proliferation created_by: dph creation_date: 2010-11-18T09:29:47Z [Term] id: GO:2000256 name: positive regulation of male germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol] is_a: GO:1905938 ! positive regulation of germ cell proliferation is_a: GO:2000254 ! regulation of male germ cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002176 ! male germ cell proliferation relationship: positively_regulates GO:0002176 ! male germ cell proliferation created_by: dph creation_date: 2010-11-18T09:29:50Z [Term] id: GO:2000257 name: regulation of protein activation cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "regulation of protein activation pathway" EXACT [GOC:obol] synonym: "regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072376 ! protein activation cascade relationship: regulates GO:0072376 ! protein activation cascade created_by: midori creation_date: 2010-11-23T11:33:46Z [Term] id: GO:2000258 name: negative regulation of protein activation cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol] synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072376 ! protein activation cascade relationship: negatively_regulates GO:0072376 ! protein activation cascade created_by: midori creation_date: 2010-11-23T11:33:51Z [Term] id: GO:2000259 name: positive regulation of protein activation cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol] synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072376 ! protein activation cascade relationship: positively_regulates GO:0072376 ! protein activation cascade created_by: midori creation_date: 2010-11-23T11:33:55Z [Term] id: GO:2000260 name: regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072377 ! blood coagulation, common pathway relationship: regulates GO:0072377 ! blood coagulation, common pathway created_by: midori creation_date: 2010-11-23T11:42:40Z [Term] id: GO:2000261 name: negative regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000260 ! regulation of blood coagulation, common pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072377 ! blood coagulation, common pathway relationship: negatively_regulates GO:0072377 ! blood coagulation, common pathway created_by: midori creation_date: 2010-11-23T11:42:44Z [Term] id: GO:2000262 name: positive regulation of blood coagulation, common pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000260 ! regulation of blood coagulation, common pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072377 ! blood coagulation, common pathway relationship: positively_regulates GO:0072377 ! blood coagulation, common pathway created_by: midori creation_date: 2010-11-23T11:42:48Z [Term] id: GO:2000263 name: regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007598 ! blood coagulation, extrinsic pathway relationship: regulates GO:0007598 ! blood coagulation, extrinsic pathway created_by: midori creation_date: 2010-11-23T11:44:35Z [Term] id: GO:2000264 name: negative regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway relationship: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway created_by: midori creation_date: 2010-11-23T11:44:42Z [Term] id: GO:2000265 name: positive regulation of blood coagulation, extrinsic pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway relationship: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway created_by: midori creation_date: 2010-11-23T11:44:46Z [Term] id: GO:2000266 name: regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007597 ! blood coagulation, intrinsic pathway relationship: regulates GO:0007597 ! blood coagulation, intrinsic pathway created_by: midori creation_date: 2010-11-23T11:45:40Z [Term] id: GO:2000267 name: negative regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:2000258 ! negative regulation of protein activation cascade is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway relationship: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway created_by: midori creation_date: 2010-11-23T11:45:46Z [Term] id: GO:2000268 name: positive regulation of blood coagulation, intrinsic pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:2000259 ! positive regulation of protein activation cascade is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway relationship: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway created_by: midori creation_date: 2010-11-23T11:45:51Z [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "regulation of fibroblast apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044346 ! fibroblast apoptotic process relationship: regulates GO:0044346 ! fibroblast apoptotic process created_by: jane creation_date: 2010-11-23T01:07:23Z [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "negative regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044346 ! fibroblast apoptotic process relationship: negatively_regulates GO:0044346 ! fibroblast apoptotic process created_by: jane creation_date: 2010-11-23T01:07:27Z [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "positive regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044346 ! fibroblast apoptotic process relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process created_by: jane creation_date: 2010-11-23T01:07:29Z [Term] id: GO:2000272 name: negative regulation of signaling receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol] synonym: "negative regulation of receptor activity" BROAD [] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044092 ! negative regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038023 ! signaling receptor activity relationship: negatively_regulates GO:0038023 ! signaling receptor activity created_by: rfoulger creation_date: 2010-12-02T09:28:47Z [Term] id: GO:2000273 name: positive regulation of signaling receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." [GOC:obol] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044093 ! positive regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038023 ! signaling receptor activity relationship: positively_regulates GO:0038023 ! signaling receptor activity created_by: rfoulger creation_date: 2010-12-02T09:28:50Z [Term] id: GO:2000274 name: regulation of epithelial cell migration, open tracheal system namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol] synonym: "regulation of tracheal cell migration" RELATED [GOC:obol] synonym: "regulation of tracheal epithelial cell migration" RELATED [GOC:obol] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007427 ! epithelial cell migration, open tracheal system relationship: regulates GO:0007427 ! epithelial cell migration, open tracheal system created_by: sart creation_date: 2010-12-03T02:08:43Z [Term] id: GO:2000275 name: regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0017077 ! oxidative phosphorylation uncoupler activity relationship: regulates GO:0017077 ! oxidative phosphorylation uncoupler activity created_by: midori creation_date: 2010-12-07T12:14:54Z [Term] id: GO:2000276 name: negative regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "negative regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "negative regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity relationship: negatively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity created_by: midori creation_date: 2010-12-07T12:14:59Z [Term] id: GO:2000277 name: positive regulation of oxidative phosphorylation uncoupler activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] synonym: "positive regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] synonym: "positive regulation of uncoupling protein activity" RELATED [GOC:obol] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity relationship: positively_regulates GO:0017077 ! oxidative phosphorylation uncoupler activity created_by: midori creation_date: 2010-12-07T12:15:02Z [Term] id: GO:2000278 name: regulation of DNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "regulation of DNA anabolism" EXACT [GOC:obol] synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of DNA formation" EXACT [GOC:obol] synonym: "regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071897 ! DNA biosynthetic process relationship: regulates GO:0071897 ! DNA biosynthetic process created_by: yaf creation_date: 2010-12-08T04:48:15Z [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of DNA formation" EXACT [GOC:obol] synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071897 ! DNA biosynthetic process relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process created_by: yaf creation_date: 2010-12-08T04:48:20Z [Term] id: GO:2000280 name: regulation of root development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of root development." [GOC:obol] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048364 ! root development relationship: regulates GO:0048364 ! root development created_by: dhl creation_date: 2010-12-08T09:30:21Z [Term] id: GO:2000281 name: regulation of histone H3-T3 phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol] is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation is_a: GO:0033127 ! regulation of histone phosphorylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072355 ! histone H3-T3 phosphorylation relationship: regulates GO:0072355 ! histone H3-T3 phosphorylation created_by: vw creation_date: 2010-12-10T11:48:31Z [Term] id: GO:2000282 name: regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008652 ! cellular amino acid biosynthetic process relationship: regulates GO:0008652 ! cellular amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:19Z [Term] id: GO:2000283 name: negative regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:23Z [Term] id: GO:2000284 name: positive regulation of cellular amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process relationship: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:27Z [Term] id: GO:2000285 name: obsolete negative regulation of regulation of excitatory postsynaptic membrane potential namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF] comment: This term was made obsolete because it makes no sense and was added in error. synonym: "negative regulation of EPSP" RELATED [GOC:obol] synonym: "negative regulation of regulation of excitatory postsynaptic membrane potential" EXACT [] is_obsolete: true replaced_by: GO:0090394 created_by: vk creation_date: 2010-12-12T03:27:21Z [Term] id: GO:2000286 name: receptor internalization involved in canonical Wnt signaling pathway namespace: biological_process def: "A receptor internalization process that contributes to canonical Wnt signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161] synonym: "receptor internalization involved in canonical Wnt receptor signaling pathway" EXACT [] synonym: "receptor internalization involved in canonical Wnt receptor signalling pathway" EXACT [GOC:obol] synonym: "receptor internalization involved in canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "receptor internalization involved in frizzled-1 receptor signaling pathway" RELATED [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:obol] synonym: "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:obol] is_a: GO:0031623 ! receptor internalization intersection_of: GO:0031623 ! receptor internalization intersection_of: part_of GO:0060070 ! canonical Wnt signaling pathway relationship: part_of GO:0060070 ! canonical Wnt signaling pathway created_by: midori creation_date: 2010-12-15T12:25:40Z [Term] id: GO:2000287 name: positive regulation of myotome development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061055 ! myotome development relationship: positively_regulates GO:0061055 ! myotome development created_by: rl creation_date: 2010-12-16T05:17:15Z [Term] id: GO:2000288 name: positive regulation of myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051450 ! myoblast proliferation relationship: positively_regulates GO:0051450 ! myoblast proliferation created_by: rl creation_date: 2010-12-16T05:20:52Z [Term] id: GO:2000289 name: regulation of photoreceptor cell axon guidance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah] synonym: "regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072499 ! photoreceptor cell axon guidance relationship: regulates GO:0072499 ! photoreceptor cell axon guidance created_by: midori creation_date: 2010-12-17T10:04:35Z [Term] id: GO:2000290 name: regulation of myotome development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061055 ! myotome development relationship: regulates GO:0061055 ! myotome development created_by: midori creation_date: 2010-12-20T10:22:05Z [Term] id: GO:2000291 name: regulation of myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051450 ! myoblast proliferation relationship: regulates GO:0051450 ! myoblast proliferation created_by: midori creation_date: 2010-12-20T10:34:26Z [Term] id: GO:2000292 name: regulation of defecation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0044062 ! regulation of excretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030421 ! defecation relationship: regulates GO:0030421 ! defecation created_by: rfoulger creation_date: 2010-12-21T09:23:08Z [Term] id: GO:2000293 name: negative regulation of defecation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030421 ! defecation relationship: negatively_regulates GO:0030421 ! defecation created_by: rfoulger creation_date: 2010-12-21T09:23:13Z [Term] id: GO:2000294 name: positive regulation of defecation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030421 ! defecation relationship: positively_regulates GO:0030421 ! defecation created_by: rfoulger creation_date: 2010-12-21T09:23:16Z [Term] id: GO:2000295 name: regulation of hydrogen peroxide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] synonym: "regulation of detoxification of H2O2" RELATED [GOC:obol] synonym: "regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] synonym: "regulation of H2O2 catabolic process" EXACT [GOC:obol] synonym: "regulation of H2O2 scavenging" RELATED [GOC:obol] synonym: "regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide degradation" EXACT [GOC:obol] synonym: "regulation of hydrogen peroxide removal" RELATED [GOC:obol] synonym: "regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042744 ! hydrogen peroxide catabolic process relationship: regulates GO:0042744 ! hydrogen peroxide catabolic process created_by: rl creation_date: 2010-12-21T03:30:51Z [Term] id: GO:2000296 name: negative regulation of hydrogen peroxide catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] synonym: "negative regulation of detoxification of H2O2" RELATED [GOC:obol] synonym: "negative regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] synonym: "negative regulation of H2O2 catabolic process" EXACT [GOC:obol] synonym: "negative regulation of H2O2 scavenging" RELATED [GOC:obol] synonym: "negative regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide degradation" EXACT [GOC:obol] synonym: "negative regulation of hydrogen peroxide removal" RELATED [GOC:obol] synonym: "negative regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process relationship: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process created_by: rl creation_date: 2010-12-21T03:30:55Z [Term] id: GO:2000297 name: negative regulation of synapse maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah] synonym: "negative regulation of synaptic maturation" EXACT [GOC:obol] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0090128 ! regulation of synapse maturation is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060074 ! synapse maturation relationship: negatively_regulates GO:0060074 ! synapse maturation created_by: midori creation_date: 2010-12-23T11:37:31Z [Term] id: GO:2000298 name: regulation of Rho-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] synonym: "regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] synonym: "regulation of ROCK kinase activity" EXACT [GOC:obol] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity relationship: regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity created_by: midori creation_date: 2010-12-23T11:44:50Z [Term] id: GO:2000299 name: negative regulation of Rho-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] synonym: "negative regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of ROCK kinase activity" EXACT [GOC:obol] is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity is_a: GO:2000298 ! regulation of Rho-dependent protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity relationship: negatively_regulates GO:0072518 ! Rho-dependent protein serine/threonine kinase activity created_by: midori creation_date: 2010-12-23T11:44:57Z [Term] id: GO:2000300 name: regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] subset: goslim_synapse is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0098693 ! regulation of synaptic vesicle cycle is_a: GO:1903305 ! regulation of regulated secretory pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016079 ! synaptic vesicle exocytosis relationship: regulates GO:0016079 ! synaptic vesicle exocytosis created_by: dph creation_date: 2011-01-03T08:20:40Z [Term] id: GO:2000301 name: negative regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:1903306 ! negative regulation of regulated secretory pathway is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis relationship: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis created_by: dph creation_date: 2011-01-03T08:21:00Z [Term] id: GO:2000302 name: positive regulation of synaptic vesicle exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:1903307 ! positive regulation of regulated secretory pathway is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016079 ! synaptic vesicle exocytosis relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis created_by: dph creation_date: 2011-01-03T08:21:14Z [Term] id: GO:2000303 name: regulation of ceramide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph] synonym: "regulation of ceramide anabolism" EXACT [GOC:obol] synonym: "regulation of ceramide biosynthesis" EXACT [GOC:obol] synonym: "regulation of ceramide formation" EXACT [GOC:obol] synonym: "regulation of ceramide synthesis" EXACT [GOC:obol] is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046513 ! ceramide biosynthetic process relationship: regulates GO:0046513 ! ceramide biosynthetic process created_by: dph creation_date: 2011-01-04T02:37:12Z [Term] id: GO:2000304 name: positive regulation of ceramide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph] synonym: "positive regulation of ceramide anabolism" EXACT [GOC:obol] synonym: "positive regulation of ceramide biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of ceramide formation" EXACT [GOC:obol] synonym: "positive regulation of ceramide synthesis" EXACT [GOC:obol] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process is_a: GO:2000303 ! regulation of ceramide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046513 ! ceramide biosynthetic process relationship: positively_regulates GO:0046513 ! ceramide biosynthetic process created_by: dph creation_date: 2011-01-04T02:37:32Z [Term] id: GO:2000305 name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance namespace: biological_process def: "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol] synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] is_a: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: GO:0071526 ! semaphorin-plexin signaling pathway intersection_of: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance relationship: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance created_by: sart creation_date: 2011-01-07T01:42:34Z [Term] id: GO:2000306 name: positive regulation of photomorphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol] synonym: "positive regulation of plant development in response to light" EXACT [GOC:obol] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009640 ! photomorphogenesis relationship: positively_regulates GO:0009640 ! photomorphogenesis created_by: dhl creation_date: 2011-01-12T07:09:02Z [Term] id: GO:2000307 name: regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "regulation of RANKL production" EXACT [GOC:obol] synonym: "regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production relationship: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production created_by: midori creation_date: 2011-01-17T10:44:00Z [Term] id: GO:2000308 name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of RANKL production" EXACT [GOC:obol] synonym: "negative regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production relationship: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production created_by: midori creation_date: 2011-01-17T10:44:33Z [Term] id: GO:2000309 name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of RANKL production" EXACT [GOC:obol] synonym: "positive regulation of TNFSF11 production" EXACT [GOC:obol] is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production relationship: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production created_by: midori creation_date: 2011-01-17T10:44:54Z [Term] id: GO:2000310 name: regulation of NMDA receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF] synonym: "regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [] is_a: GO:0099601 ! regulation of neurotransmitter receptor activity is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004972 ! NMDA glutamate receptor activity relationship: regulates GO:0004972 ! NMDA glutamate receptor activity created_by: rfoulger creation_date: 2011-01-18T10:06:37Z [Term] id: GO:2000311 name: regulation of AMPA receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity." [GOC:BHF] synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT [] is_a: GO:0099601 ! regulation of neurotransmitter receptor activity is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004971 ! AMPA glutamate receptor activity relationship: regulates GO:0004971 ! AMPA glutamate receptor activity created_by: rfoulger creation_date: 2011-01-18T10:10:28Z [Term] id: GO:2000312 name: regulation of kainate selective glutamate receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF] is_a: GO:0099601 ! regulation of neurotransmitter receptor activity is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015277 ! kainate selective glutamate receptor activity relationship: regulates GO:0015277 ! kainate selective glutamate receptor activity created_by: rfoulger creation_date: 2011-01-18T10:14:16Z [Term] id: GO:2000313 name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation relationship: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation created_by: vk creation_date: 2011-01-18T10:26:22Z [Term] id: GO:2000314 name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation relationship: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation created_by: vk creation_date: 2011-01-18T10:26:56Z [Term] id: GO:2000315 name: positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] synonym: "positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation relationship: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation created_by: vk creation_date: 2011-01-18T10:27:19Z [Term] id: GO:2000316 name: regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072538 ! T-helper 17 type immune response relationship: regulates GO:0072538 ! T-helper 17 type immune response created_by: midori creation_date: 2011-01-18T01:32:26Z [Term] id: GO:2000317 name: negative regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072538 ! T-helper 17 type immune response relationship: negatively_regulates GO:0072538 ! T-helper 17 type immune response created_by: midori creation_date: 2011-01-18T01:33:00Z [Term] id: GO:2000318 name: positive regulation of T-helper 17 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072538 ! T-helper 17 type immune response relationship: positively_regulates GO:0072538 ! T-helper 17 type immune response created_by: midori creation_date: 2011-01-18T01:33:24Z [Term] id: GO:2000319 name: regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045622 ! regulation of T-helper cell differentiation is_a: GO:2000316 ! regulation of T-helper 17 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072539 ! T-helper 17 cell differentiation relationship: regulates GO:0072539 ! T-helper 17 cell differentiation created_by: midori creation_date: 2011-01-18T01:43:48Z [Term] id: GO:2000320 name: negative regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045623 ! negative regulation of T-helper cell differentiation is_a: GO:2000317 ! negative regulation of T-helper 17 type immune response is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation relationship: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation created_by: midori creation_date: 2011-01-18T01:44:31Z [Term] id: GO:2000321 name: positive regulation of T-helper 17 cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol] is_a: GO:0045624 ! positive regulation of T-helper cell differentiation is_a: GO:2000318 ! positive regulation of T-helper 17 type immune response is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072539 ! T-helper 17 cell differentiation relationship: positively_regulates GO:0072539 ! T-helper 17 cell differentiation created_by: midori creation_date: 2011-01-18T01:45:08Z [Term] id: GO:2000322 name: regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042921 ! glucocorticoid receptor signaling pathway relationship: regulates GO:0042921 ! glucocorticoid receptor signaling pathway created_by: vk creation_date: 2011-01-18T04:38:10Z [Term] id: GO:2000323 name: negative regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "negative regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway relationship: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway created_by: vk creation_date: 2011-01-18T04:38:43Z [Term] id: GO:2000324 name: positive regulation of glucocorticoid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] synonym: "positive regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway relationship: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway created_by: vk creation_date: 2011-01-18T04:39:05Z [Term] id: GO:2000325 name: regulation of nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] synonym: "regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] is_a: GO:0065009 ! regulation of molecular function is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030374 ! nuclear receptor transcription coactivator activity relationship: regulates GO:0030374 ! nuclear receptor transcription coactivator activity created_by: vk creation_date: 2011-01-18T06:29:32Z [Term] id: GO:2000326 name: negative regulation of nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "negative regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] synonym: "negative regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000325 ! regulation of nuclear receptor transcription coactivator activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030374 ! nuclear receptor transcription coactivator activity relationship: negatively_regulates GO:0030374 ! nuclear receptor transcription coactivator activity created_by: vk creation_date: 2011-01-18T06:30:03Z [Term] id: GO:2000327 name: positive regulation of nuclear receptor transcription coactivator activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] synonym: "positive regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] synonym: "positive regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription is_a: GO:2000325 ! regulation of nuclear receptor transcription coactivator activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030374 ! nuclear receptor transcription coactivator activity relationship: positively_regulates GO:0030374 ! nuclear receptor transcription coactivator activity created_by: vk creation_date: 2011-01-18T06:30:23Z [Term] id: GO:2000328 name: regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072540 ! T-helper 17 cell lineage commitment relationship: regulates GO:0072540 ! T-helper 17 cell lineage commitment created_by: midori creation_date: 2011-01-19T09:31:19Z [Term] id: GO:2000329 name: negative regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "negative regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "negative regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "negative regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:2000320 ! negative regulation of T-helper 17 cell differentiation is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment relationship: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment created_by: midori creation_date: 2011-01-19T09:31:53Z [Term] id: GO:2000330 name: positive regulation of T-helper 17 cell lineage commitment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] synonym: "positive regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] synonym: "positive regulation of Th17 cell lineage commitment" EXACT [GOC:obol] synonym: "positive regulation of Th17 fate commitment" EXACT [GOC:obol] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:2000321 ! positive regulation of T-helper 17 cell differentiation is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment relationship: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment created_by: midori creation_date: 2011-01-19T09:32:16Z [Term] id: GO:2000331 name: regulation of terminal button organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] synonym: "regulation of bouton organization" EXACT [GOC:obol] synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal bouton organization" EXACT [GOC:obol] synonym: "regulation of terminal button organisation" EXACT [GOC:obol] is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072553 ! terminal button organization relationship: regulates GO:0072553 ! terminal button organization created_by: midori creation_date: 2011-01-28T11:29:08Z [Term] id: GO:2000332 name: regulation of blood microparticle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "regulation of microparticle generation" EXACT [GOC:obol] synonym: "regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072564 ! blood microparticle formation relationship: regulates GO:0072564 ! blood microparticle formation created_by: midori creation_date: 2011-01-31T11:18:11Z [Term] id: GO:2000333 name: negative regulation of blood microparticle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "negative regulation of microparticle generation" EXACT [GOC:obol] synonym: "negative regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000332 ! regulation of blood microparticle formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072564 ! blood microparticle formation relationship: negatively_regulates GO:0072564 ! blood microparticle formation created_by: midori creation_date: 2011-01-31T11:18:18Z [Term] id: GO:2000334 name: positive regulation of blood microparticle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] synonym: "positive regulation of microparticle generation" EXACT [GOC:obol] synonym: "positive regulation of microparticle release" EXACT [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000332 ! regulation of blood microparticle formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072564 ! blood microparticle formation relationship: positively_regulates GO:0072564 ! blood microparticle formation created_by: midori creation_date: 2011-01-31T11:18:23Z [Term] id: GO:2000335 name: regulation of endothelial microparticle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000332 ! regulation of blood microparticle formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072565 ! endothelial microparticle formation relationship: regulates GO:0072565 ! endothelial microparticle formation created_by: midori creation_date: 2011-01-31T11:20:26Z [Term] id: GO:2000336 name: negative regulation of endothelial microparticle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "negative regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "negative regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000333 ! negative regulation of blood microparticle formation is_a: GO:2000335 ! regulation of endothelial microparticle formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072565 ! endothelial microparticle formation relationship: negatively_regulates GO:0072565 ! endothelial microparticle formation created_by: midori creation_date: 2011-01-31T11:20:33Z [Term] id: GO:2000337 name: positive regulation of endothelial microparticle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] synonym: "positive regulation of endothelial microparticle generation" EXACT [GOC:obol] synonym: "positive regulation of endothelial microparticle release" EXACT [GOC:obol] is_a: GO:2000334 ! positive regulation of blood microparticle formation is_a: GO:2000335 ! regulation of endothelial microparticle formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072565 ! endothelial microparticle formation relationship: positively_regulates GO:0072565 ! endothelial microparticle formation created_by: midori creation_date: 2011-01-31T11:20:38Z [Term] id: GO:2000338 name: regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "regulation of CXCL1 production" EXACT [GOC:obol] synonym: "regulation of KC production" EXACT [GOC:obol] synonym: "regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production relationship: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production created_by: midori creation_date: 2011-02-01T10:46:27Z [Term] id: GO:2000339 name: negative regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of CXCL1 production" EXACT [GOC:obol] synonym: "negative regulation of KC production" EXACT [GOC:obol] synonym: "negative regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "negative regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production relationship: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production created_by: midori creation_date: 2011-02-01T10:46:31Z [Term] id: GO:2000340 name: positive regulation of chemokine (C-X-C motif) ligand 1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of CXCL1 production" EXACT [GOC:obol] synonym: "positive regulation of KC production" EXACT [GOC:obol] synonym: "positive regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] synonym: "positive regulation of SCYB1 production" EXACT [GOC:obol] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production relationship: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production created_by: midori creation_date: 2011-02-01T10:46:33Z [Term] id: GO:2000341 name: regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "regulation of CXCL2 production" EXACT [GOC:obol] synonym: "regulation of MIP-2 production" EXACT [GOC:obol] synonym: "regulation of MIP2 production" EXACT [GOC:obol] synonym: "regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production relationship: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production created_by: midori creation_date: 2011-02-01T11:57:14Z [Term] id: GO:2000342 name: negative regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP2 production" EXACT [GOC:obol] synonym: "negative regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production relationship: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production created_by: midori creation_date: 2011-02-01T11:57:17Z [Term] id: GO:2000343 name: positive regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP2 production" EXACT [GOC:obol] synonym: "positive regulation of SCYB2 production" EXACT [GOC:obol] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production relationship: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production created_by: midori creation_date: 2011-02-01T11:57:20Z [Term] id: GO:2000344 name: positive regulation of acrosome reaction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol] is_a: GO:0060046 ! regulation of acrosome reaction is_a: GO:1905516 ! positive regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007340 ! acrosome reaction relationship: positively_regulates GO:0007340 ! acrosome reaction created_by: yaf creation_date: 2011-02-01T12:02:18Z [Term] id: GO:2000345 name: regulation of hepatocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072574 ! hepatocyte proliferation relationship: regulates GO:0072574 ! hepatocyte proliferation created_by: midori creation_date: 2011-02-03T10:27:15Z [Term] id: GO:2000346 name: negative regulation of hepatocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000345 ! regulation of hepatocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072574 ! hepatocyte proliferation relationship: negatively_regulates GO:0072574 ! hepatocyte proliferation created_by: midori creation_date: 2011-02-03T10:27:20Z [Term] id: GO:2000347 name: positive regulation of hepatocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000345 ! regulation of hepatocyte proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072574 ! hepatocyte proliferation relationship: positively_regulates GO:0072574 ! hepatocyte proliferation created_by: midori creation_date: 2011-02-03T10:27:24Z [Term] id: GO:2000348 name: regulation of CD40 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah] synonym: "regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0023035 ! CD40 signaling pathway relationship: regulates GO:0023035 ! CD40 signaling pathway created_by: midori creation_date: 2011-02-03T10:29:40Z [Term] id: GO:2000349 name: negative regulation of CD40 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] synonym: "negative regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2000348 ! regulation of CD40 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0023035 ! CD40 signaling pathway relationship: negatively_regulates GO:0023035 ! CD40 signaling pathway created_by: midori creation_date: 2011-02-03T10:29:44Z [Term] id: GO:2000350 name: positive regulation of CD40 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] synonym: "positive regulation of CD40 signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000348 ! regulation of CD40 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0023035 ! CD40 signaling pathway relationship: positively_regulates GO:0023035 ! CD40 signaling pathway created_by: midori creation_date: 2011-02-03T10:29:46Z [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "regulation of endothelial cell apoptosis" NARROW [] synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072577 ! endothelial cell apoptotic process relationship: regulates GO:0072577 ! endothelial cell apoptotic process created_by: midori creation_date: 2011-02-03T10:43:16Z [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of endothelial cell apoptosis" NARROW [] synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072577 ! endothelial cell apoptotic process relationship: negatively_regulates GO:0072577 ! endothelial cell apoptotic process created_by: midori creation_date: 2011-02-03T10:43:20Z [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of endothelial cell apoptosis" NARROW [] synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072577 ! endothelial cell apoptotic process relationship: positively_regulates GO:0072577 ! endothelial cell apoptotic process created_by: midori creation_date: 2011-02-03T10:43:23Z [Term] id: GO:2000354 name: regulation of ovarian follicle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "regulation of follicular phase" RELATED [GOC:obol] is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001541 ! ovarian follicle development relationship: regulates GO:0001541 ! ovarian follicle development created_by: yaf creation_date: 2011-02-03T02:01:28Z [Term] id: GO:2000355 name: negative regulation of ovarian follicle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "negative regulation of follicular phase" RELATED [GOC:obol] is_a: GO:2000195 ! negative regulation of female gonad development is_a: GO:2000354 ! regulation of ovarian follicle development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001541 ! ovarian follicle development relationship: negatively_regulates GO:0001541 ! ovarian follicle development created_by: yaf creation_date: 2011-02-03T02:01:32Z [Term] id: GO:2000356 name: regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation is_a: GO:0090183 ! regulation of kidney development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072195 ! kidney smooth muscle cell differentiation relationship: regulates GO:0072195 ! kidney smooth muscle cell differentiation created_by: yaf creation_date: 2011-02-03T02:14:24Z [Term] id: GO:2000357 name: negative regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:1905900 ! negative regulation of smooth muscle tissue development is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation relationship: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation created_by: yaf creation_date: 2011-02-03T02:14:28Z [Term] id: GO:2000358 name: positive regulation of kidney smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:1905901 ! positive regulation of smooth muscle tissue development is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation relationship: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation created_by: yaf creation_date: 2011-02-03T02:14:31Z [Term] id: GO:2000359 name: regulation of binding of sperm to zona pellucida namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] synonym: "regulation of ZPG binding" RELATED [GOC:obol] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080154 ! regulation of fertilization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007339 ! binding of sperm to zona pellucida relationship: regulates GO:0007339 ! binding of sperm to zona pellucida created_by: yaf creation_date: 2011-02-03T02:42:50Z [Term] id: GO:2000360 name: negative regulation of binding of sperm to zona pellucida namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] synonym: "negative regulation of ZPG binding" RELATED [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0060467 ! negative regulation of fertilization is_a: GO:2000359 ! regulation of binding of sperm to zona pellucida intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida relationship: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida created_by: yaf creation_date: 2011-02-03T02:42:54Z [Term] id: GO:2000361 name: regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0010911 ! regulation of isomerase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0050220 ! prostaglandin-E synthase activity relationship: regulates GO:0050220 ! prostaglandin-E synthase activity created_by: rfoulger creation_date: 2011-02-03T04:05:35Z [Term] id: GO:2000362 name: negative regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "negative regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050220 ! prostaglandin-E synthase activity relationship: negatively_regulates GO:0050220 ! prostaglandin-E synthase activity created_by: rfoulger creation_date: 2011-02-03T04:05:39Z [Term] id: GO:2000363 name: positive regulation of prostaglandin-E synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] synonym: "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of endoperoxide isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGE isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGE2 isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] synonym: "positive regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] is_a: GO:0010912 ! positive regulation of isomerase activity is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050220 ! prostaglandin-E synthase activity relationship: positively_regulates GO:0050220 ! prostaglandin-E synthase activity created_by: rfoulger creation_date: 2011-02-03T04:05:42Z [Term] id: GO:2000367 name: regulation of acrosomal vesicle exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] synonym: "regulation of acrosomal granule exocytosis" RELATED [GOC:obol] synonym: "regulation of acrosome exocytosis" EXACT [GOC:obol] is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis is_a: GO:0060046 ! regulation of acrosome reaction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060478 ! acrosomal vesicle exocytosis relationship: regulates GO:0060478 ! acrosomal vesicle exocytosis created_by: yaf creation_date: 2011-02-07T11:52:34Z [Term] id: GO:2000368 name: positive regulation of acrosomal vesicle exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] synonym: "positive regulation of acrosomal granule exocytosis" RELATED [GOC:obol] synonym: "positive regulation of acrosome exocytosis" EXACT [GOC:obol] is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis is_a: GO:2000344 ! positive regulation of acrosome reaction is_a: GO:2000367 ! regulation of acrosomal vesicle exocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis relationship: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis created_by: yaf creation_date: 2011-02-07T11:52:42Z [Term] id: GO:2000369 name: regulation of clathrin-dependent endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah] synonym: "regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] synonym: "regulation of clathrin-dependent endocytosis" EXACT [GOC:obol] synonym: "regulation of clathrin-mediated endocytosis" EXACT [] is_a: GO:0048259 ! regulation of receptor-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072583 ! clathrin-dependent endocytosis relationship: regulates GO:0072583 ! clathrin-dependent endocytosis created_by: midori creation_date: 2011-02-09T12:36:18Z [Term] id: GO:2000370 name: positive regulation of clathrin-dependent endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah] synonym: "positive regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] synonym: "positive regulation of clathrin-dependent endocytosis" EXACT [GOC:obol] synonym: "positive regulation of clathrin-mediated endocytosis" EXACT [] is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072583 ! clathrin-dependent endocytosis relationship: positively_regulates GO:0072583 ! clathrin-dependent endocytosis created_by: midori creation_date: 2011-02-09T12:36:28Z [Term] id: GO:2000371 name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "regulation of topoisomerase" RELATED [GOC:obol] synonym: "regulation of topoisomerase II" EXACT [GOC:obol] synonym: "regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0010911 ! regulation of isomerase activity is_a: GO:0043462 ! regulation of ATPase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity relationship: regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity created_by: midori creation_date: 2011-02-09T02:35:27Z [Term] id: GO:2000372 name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "negative regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "negative regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "negative regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "negative regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "negative regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "negative regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "negative regulation of topoisomerase" RELATED [GOC:obol] synonym: "negative regulation of topoisomerase II" EXACT [GOC:obol] synonym: "negative regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity relationship: negatively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity created_by: midori creation_date: 2011-02-09T02:35:36Z [Term] id: GO:2000373 name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] synonym: "positive regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] synonym: "positive regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] synonym: "positive regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] synonym: "positive regulation of DNA topoisomerase II" RELATED [GOC:obol] synonym: "positive regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] synonym: "positive regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] synonym: "positive regulation of topoisomerase" RELATED [GOC:obol] synonym: "positive regulation of topoisomerase II" EXACT [GOC:obol] synonym: "positive regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] is_a: GO:0010912 ! positive regulation of isomerase activity is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity relationship: positively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity created_by: midori creation_date: 2011-02-09T02:35:43Z [Term] id: GO:2000374 name: regulation of oxygen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072592 ! oxygen metabolic process relationship: regulates GO:0072592 ! oxygen metabolic process created_by: midori creation_date: 2011-02-11T02:03:32Z [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072592 ! oxygen metabolic process relationship: negatively_regulates GO:0072592 ! oxygen metabolic process created_by: midori creation_date: 2011-02-11T02:03:44Z [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072592 ! oxygen metabolic process relationship: positively_regulates GO:0072592 ! oxygen metabolic process created_by: midori creation_date: 2011-02-11T02:03:52Z [Term] id: GO:2000377 name: regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072593 ! reactive oxygen species metabolic process relationship: regulates GO:0072593 ! reactive oxygen species metabolic process created_by: midori creation_date: 2011-02-11T02:06:36Z [Term] id: GO:2000378 name: negative regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process relationship: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process created_by: midori creation_date: 2011-02-11T02:06:49Z [Term] id: GO:2000379 name: positive regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072593 ! reactive oxygen species metabolic process relationship: positively_regulates GO:0072593 ! reactive oxygen species metabolic process created_by: midori creation_date: 2011-02-11T02:06:57Z [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007498 ! mesoderm development relationship: regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:09:46Z [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007498 ! mesoderm development relationship: negatively_regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:10:02Z [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007498 ! mesoderm development relationship: positively_regulates GO:0007498 ! mesoderm development created_by: vk creation_date: 2011-02-15T03:10:12Z [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007398 ! ectoderm development relationship: regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:10Z [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007398 ! ectoderm development relationship: negatively_regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:27Z [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007398 ! ectoderm development relationship: positively_regulates GO:0007398 ! ectoderm development created_by: vk creation_date: 2011-02-15T03:17:39Z [Term] id: GO:2000386 name: positive regulation of ovarian follicle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol] synonym: "positive regulation of follicular phase" RELATED [GOC:obol] is_a: GO:2000196 ! positive regulation of female gonad development is_a: GO:2000354 ! regulation of ovarian follicle development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001541 ! ovarian follicle development relationship: positively_regulates GO:0001541 ! ovarian follicle development created_by: yaf creation_date: 2011-02-16T02:21:21Z [Term] id: GO:2000387 name: regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:2000354 ! regulation of ovarian follicle development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001547 ! antral ovarian follicle growth relationship: regulates GO:0001547 ! antral ovarian follicle growth created_by: yaf creation_date: 2011-02-16T04:53:43Z [Term] id: GO:2000388 name: positive regulation of antral ovarian follicle growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:2000386 ! positive regulation of ovarian follicle development is_a: GO:2000387 ! regulation of antral ovarian follicle growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001547 ! antral ovarian follicle growth relationship: positively_regulates GO:0001547 ! antral ovarian follicle growth created_by: yaf creation_date: 2011-02-16T04:54:01Z [Term] id: GO:2000389 name: regulation of neutrophil extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil extravasation." [GOC:mah] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:1902622 ! regulation of neutrophil migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072672 ! neutrophil extravasation relationship: regulates GO:0072672 ! neutrophil extravasation created_by: midori creation_date: 2011-02-22T11:07:58Z [Term] id: GO:2000390 name: negative regulation of neutrophil extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:1902623 ! negative regulation of neutrophil migration is_a: GO:2000389 ! regulation of neutrophil extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072672 ! neutrophil extravasation relationship: negatively_regulates GO:0072672 ! neutrophil extravasation created_by: midori creation_date: 2011-02-22T11:08:23Z [Term] id: GO:2000391 name: positive regulation of neutrophil extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:1902624 ! positive regulation of neutrophil migration is_a: GO:2000389 ! regulation of neutrophil extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072672 ! neutrophil extravasation relationship: positively_regulates GO:0072672 ! neutrophil extravasation created_by: midori creation_date: 2011-02-22T11:08:42Z [Term] id: GO:2000392 name: regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah] synonym: "regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:1902743 ! regulation of lamellipodium organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072673 ! lamellipodium morphogenesis relationship: regulates GO:0072673 ! lamellipodium morphogenesis created_by: midori creation_date: 2011-02-22T11:18:58Z [Term] id: GO:2000393 name: negative regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] synonym: "negative regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1902744 ! negative regulation of lamellipodium organization is_a: GO:2000392 ! regulation of lamellipodium morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072673 ! lamellipodium morphogenesis relationship: negatively_regulates GO:0072673 ! lamellipodium morphogenesis created_by: midori creation_date: 2011-02-22T11:19:25Z [Term] id: GO:2000394 name: positive regulation of lamellipodium morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] synonym: "positive regulation of lamellipodium organization" RELATED [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1902745 ! positive regulation of lamellipodium organization is_a: GO:2000392 ! regulation of lamellipodium morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072673 ! lamellipodium morphogenesis relationship: positively_regulates GO:0072673 ! lamellipodium morphogenesis created_by: midori creation_date: 2011-02-22T11:19:45Z [Term] id: GO:2000395 name: regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903827 ! regulation of cellular protein localization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070086 ! ubiquitin-dependent endocytosis relationship: regulates GO:0070086 ! ubiquitin-dependent endocytosis created_by: midori creation_date: 2011-02-22T11:24:52Z [Term] id: GO:2000396 name: negative regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "negative regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903828 ! negative regulation of cellular protein localization is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis relationship: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis created_by: midori creation_date: 2011-02-22T11:25:21Z [Term] id: GO:2000397 name: positive regulation of ubiquitin-dependent endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] synonym: "positive regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903829 ! positive regulation of cellular protein localization is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis relationship: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis created_by: midori creation_date: 2011-02-22T11:25:42Z [Term] id: GO:2000398 name: regulation of thymocyte aggregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thymocyte aggregation." [GOC:mah] synonym: "regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071594 ! thymocyte aggregation relationship: regulates GO:0071594 ! thymocyte aggregation created_by: midori creation_date: 2011-02-22T02:49:19Z [Term] id: GO:2000399 name: negative regulation of thymocyte aggregation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] synonym: "negative regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "negative regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "negative regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "negative regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion is_a: GO:2000398 ! regulation of thymocyte aggregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071594 ! thymocyte aggregation relationship: negatively_regulates GO:0071594 ! thymocyte aggregation created_by: midori creation_date: 2011-02-22T02:49:44Z [Term] id: GO:2000400 name: positive regulation of thymocyte aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] synonym: "positive regulation of immature T cell aggregation" RELATED [GOC:obol] synonym: "positive regulation of immature T-cell aggregation" RELATED [GOC:obol] synonym: "positive regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of T cell precursor aggregation" EXACT [GOC:obol] synonym: "positive regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion is_a: GO:2000398 ! regulation of thymocyte aggregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071594 ! thymocyte aggregation relationship: positively_regulates GO:0071594 ! thymocyte aggregation created_by: midori creation_date: 2011-02-22T02:50:01Z [Term] id: GO:2000401 name: regulation of lymphocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072676 ! lymphocyte migration relationship: regulates GO:0072676 ! lymphocyte migration created_by: midori creation_date: 2011-02-23T10:45:19Z [Term] id: GO:2000402 name: negative regulation of lymphocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072676 ! lymphocyte migration relationship: negatively_regulates GO:0072676 ! lymphocyte migration created_by: midori creation_date: 2011-02-23T10:45:47Z [Term] id: GO:2000403 name: positive regulation of lymphocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072676 ! lymphocyte migration relationship: positively_regulates GO:0072676 ! lymphocyte migration created_by: midori creation_date: 2011-02-23T10:46:06Z [Term] id: GO:2000404 name: regulation of T cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "regulation of T-cell migration" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072678 ! T cell migration relationship: regulates GO:0072678 ! T cell migration created_by: midori creation_date: 2011-02-23T10:48:24Z [Term] id: GO:2000405 name: negative regulation of T cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "negative regulation of T-cell migration" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072678 ! T cell migration relationship: negatively_regulates GO:0072678 ! T cell migration created_by: midori creation_date: 2011-02-23T10:48:52Z [Term] id: GO:2000406 name: positive regulation of T cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "positive regulation of T-cell migration" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072678 ! T cell migration relationship: positively_regulates GO:0072678 ! T cell migration created_by: midori creation_date: 2011-02-23T10:49:12Z [Term] id: GO:2000407 name: regulation of T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell extravasation." [GOC:mah] synonym: "regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072683 ! T cell extravasation relationship: regulates GO:0072683 ! T cell extravasation created_by: midori creation_date: 2011-02-23T10:51:58Z [Term] id: GO:2000408 name: negative regulation of T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] synonym: "negative regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "negative regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000405 ! negative regulation of T cell migration is_a: GO:2000407 ! regulation of T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072683 ! T cell extravasation relationship: negatively_regulates GO:0072683 ! T cell extravasation created_by: midori creation_date: 2011-02-23T10:52:28Z [Term] id: GO:2000409 name: positive regulation of T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] synonym: "positive regulation of T lymphocyte extravasation" EXACT [GOC:obol] synonym: "positive regulation of T-cell extravasation" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte extravasation" EXACT [GOC:obol] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000406 ! positive regulation of T cell migration is_a: GO:2000407 ! regulation of T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072683 ! T cell extravasation relationship: positively_regulates GO:0072683 ! T cell extravasation created_by: midori creation_date: 2011-02-23T10:52:50Z [Term] id: GO:2000410 name: regulation of thymocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "regulation of immature T cell migration" RELATED [GOC:obol] synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072679 ! thymocyte migration relationship: regulates GO:0072679 ! thymocyte migration created_by: midori creation_date: 2011-02-23T01:33:32Z [Term] id: GO:2000411 name: negative regulation of thymocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000405 ! negative regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072679 ! thymocyte migration relationship: negatively_regulates GO:0072679 ! thymocyte migration created_by: midori creation_date: 2011-02-23T01:34:01Z [Term] id: GO:2000412 name: positive regulation of thymocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah] synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol] synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000406 ! positive regulation of T cell migration is_a: GO:2000410 ! regulation of thymocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072679 ! thymocyte migration relationship: positively_regulates GO:0072679 ! thymocyte migration created_by: midori creation_date: 2011-02-23T01:34:23Z [Term] id: GO:2000413 name: regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah] synonym: "regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000410 ! regulation of thymocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072681 ! fibronectin-dependent thymocyte migration relationship: regulates GO:0072681 ! fibronectin-dependent thymocyte migration created_by: midori creation_date: 2011-02-23T01:38:08Z [Term] id: GO:2000414 name: negative regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] synonym: "negative regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "negative regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000411 ! negative regulation of thymocyte migration is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration relationship: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration created_by: midori creation_date: 2011-02-23T01:38:37Z [Term] id: GO:2000415 name: positive regulation of fibronectin-dependent thymocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] synonym: "positive regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] synonym: "positive regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000412 ! positive regulation of thymocyte migration is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration relationship: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration created_by: midori creation_date: 2011-02-23T01:39:00Z [Term] id: GO:2000416 name: regulation of eosinophil migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072677 ! eosinophil migration relationship: regulates GO:0072677 ! eosinophil migration created_by: midori creation_date: 2011-02-23T01:43:23Z [Term] id: GO:2000417 name: negative regulation of eosinophil migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072677 ! eosinophil migration relationship: negatively_regulates GO:0072677 ! eosinophil migration created_by: midori creation_date: 2011-02-23T01:43:52Z [Term] id: GO:2000418 name: positive regulation of eosinophil migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072677 ! eosinophil migration relationship: positively_regulates GO:0072677 ! eosinophil migration created_by: midori creation_date: 2011-02-23T01:44:14Z [Term] id: GO:2000419 name: regulation of eosinophil extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil extravasation." [GOC:mah] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072682 ! eosinophil extravasation relationship: regulates GO:0072682 ! eosinophil extravasation created_by: midori creation_date: 2011-02-23T01:46:47Z [Term] id: GO:2000420 name: negative regulation of eosinophil extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:2000417 ! negative regulation of eosinophil migration is_a: GO:2000419 ! regulation of eosinophil extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072682 ! eosinophil extravasation relationship: negatively_regulates GO:0072682 ! eosinophil extravasation created_by: midori creation_date: 2011-02-23T01:47:18Z [Term] id: GO:2000421 name: positive regulation of eosinophil extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:2000418 ! positive regulation of eosinophil migration is_a: GO:2000419 ! regulation of eosinophil extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072682 ! eosinophil extravasation relationship: positively_regulates GO:0072682 ! eosinophil extravasation created_by: midori creation_date: 2011-02-23T01:47:42Z [Term] id: GO:2000422 name: regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:2000416 ! regulation of eosinophil migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048245 ! eosinophil chemotaxis relationship: regulates GO:0048245 ! eosinophil chemotaxis created_by: rfoulger creation_date: 2011-02-24T01:16:44Z [Term] id: GO:2000423 name: negative regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis is_a: GO:2000417 ! negative regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048245 ! eosinophil chemotaxis relationship: negatively_regulates GO:0048245 ! eosinophil chemotaxis created_by: rfoulger creation_date: 2011-02-24T01:17:12Z [Term] id: GO:2000424 name: positive regulation of eosinophil chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis is_a: GO:2000418 ! positive regulation of eosinophil migration is_a: GO:2000422 ! regulation of eosinophil chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048245 ! eosinophil chemotaxis relationship: positively_regulates GO:0048245 ! eosinophil chemotaxis created_by: rfoulger creation_date: 2011-02-24T01:17:35Z [Term] id: GO:2000425 name: regulation of apoptotic cell clearance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "regulation of efferocytosis" EXACT [GOC:obol] synonym: "regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043277 ! apoptotic cell clearance relationship: regulates GO:0043277 ! apoptotic cell clearance created_by: rfoulger creation_date: 2011-02-25T11:50:11Z [Term] id: GO:2000426 name: negative regulation of apoptotic cell clearance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "negative regulation of efferocytosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050765 ! negative regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043277 ! apoptotic cell clearance relationship: negatively_regulates GO:0043277 ! apoptotic cell clearance created_by: rfoulger creation_date: 2011-02-25T11:50:39Z [Term] id: GO:2000427 name: positive regulation of apoptotic cell clearance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol] synonym: "positive regulation of efferocytosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol] is_a: GO:0050766 ! positive regulation of phagocytosis is_a: GO:2000425 ! regulation of apoptotic cell clearance intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043277 ! apoptotic cell clearance relationship: positively_regulates GO:0043277 ! apoptotic cell clearance created_by: rfoulger creation_date: 2011-02-25T11:50:59Z [Term] id: GO:2000428 name: regulation of neutrophil aggregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070488 ! neutrophil aggregation relationship: regulates GO:0070488 ! neutrophil aggregation created_by: ebc creation_date: 2011-02-28T05:18:54Z [Term] id: GO:2000429 name: negative regulation of neutrophil aggregation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "negative regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "negative regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion is_a: GO:2000428 ! regulation of neutrophil aggregation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070488 ! neutrophil aggregation relationship: negatively_regulates GO:0070488 ! neutrophil aggregation created_by: ebc creation_date: 2011-02-28T05:19:28Z [Term] id: GO:2000430 name: positive regulation of neutrophil aggregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] synonym: "positive regulation of neutrocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] synonym: "positive regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion is_a: GO:2000428 ! regulation of neutrophil aggregation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070488 ! neutrophil aggregation relationship: positively_regulates GO:0070488 ! neutrophil aggregation created_by: ebc creation_date: 2011-02-28T05:19:51Z [Term] id: GO:2000431 name: regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110020 ! regulation of actomyosin structure organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000915 ! actomyosin contractile ring assembly relationship: regulates GO:0000915 ! actomyosin contractile ring assembly created_by: vw creation_date: 2011-03-03T12:17:41Z [Term] id: GO:2000432 name: negative regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "negative regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0032466 ! negative regulation of cytokinesis is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly relationship: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly created_by: vw creation_date: 2011-03-03T12:18:16Z [Term] id: GO:2000433 name: positive regulation of cytokinesis, actomyosin contractile ring assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] synonym: "positive regulation of contractile ring assembly" EXACT [GOC:obol] is_a: GO:0032467 ! positive regulation of cytokinesis is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000915 ! actomyosin contractile ring assembly relationship: positively_regulates GO:0000915 ! actomyosin contractile ring assembly created_by: vw creation_date: 2011-03-03T12:18:43Z [Term] id: GO:2000434 name: regulation of protein neddylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045116 ! protein neddylation relationship: regulates GO:0045116 ! protein neddylation created_by: vw creation_date: 2011-03-03T02:05:22Z [Term] id: GO:2000435 name: negative regulation of protein neddylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "negative regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal is_a: GO:2000434 ! regulation of protein neddylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045116 ! protein neddylation relationship: negatively_regulates GO:0045116 ! protein neddylation created_by: vw creation_date: 2011-03-03T02:05:56Z [Term] id: GO:2000436 name: positive regulation of protein neddylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol] synonym: "positive regulation of RUB1-protein conjugation" EXACT [GOC:obol] is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal is_a: GO:2000434 ! regulation of protein neddylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045116 ! protein neddylation relationship: positively_regulates GO:0045116 ! protein neddylation created_by: vw creation_date: 2011-03-03T02:06:19Z [Term] id: GO:2000437 name: regulation of monocyte extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002691 ! regulation of cellular extravasation is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035696 ! monocyte extravasation relationship: regulates GO:0035696 ! monocyte extravasation created_by: rfoulger creation_date: 2011-03-04T10:24:08Z [Term] id: GO:2000438 name: negative regulation of monocyte extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002692 ! negative regulation of cellular extravasation is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000437 ! regulation of monocyte extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035696 ! monocyte extravasation relationship: negatively_regulates GO:0035696 ! monocyte extravasation created_by: rfoulger creation_date: 2011-03-04T10:24:44Z [Term] id: GO:2000439 name: positive regulation of monocyte extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol] is_a: GO:0002693 ! positive regulation of cellular extravasation is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000437 ! regulation of monocyte extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035696 ! monocyte extravasation relationship: positively_regulates GO:0035696 ! monocyte extravasation created_by: rfoulger creation_date: 2011-03-04T10:25:11Z [Term] id: GO:2000440 name: regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "regulation of TLR15 signaling pathway" EXACT [GOC:obol] synonym: "regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035681 ! toll-like receptor 15 signaling pathway relationship: regulates GO:0035681 ! toll-like receptor 15 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:28:24Z [Term] id: GO:2000441 name: negative regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "negative regulation of TLR15 signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway relationship: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:29:04Z [Term] id: GO:2000442 name: positive regulation of toll-like receptor 15 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] synonym: "positive regulation of TLR15 signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway relationship: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:29:36Z [Term] id: GO:2000443 name: regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "regulation of TLR21 signaling pathway" EXACT [GOC:obol] synonym: "regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035682 ! toll-like receptor 21 signaling pathway relationship: regulates GO:0035682 ! toll-like receptor 21 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:31:48Z [Term] id: GO:2000444 name: negative regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "negative regulation of TLR21 signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway relationship: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:32:29Z [Term] id: GO:2000445 name: positive regulation of toll-like receptor 21 signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] synonym: "positive regulation of TLR21 signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway relationship: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:33:00Z [Term] id: GO:2000446 name: regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] synonym: "regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway relationship: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:37:39Z [Term] id: GO:2000447 name: negative regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "negative regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway relationship: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:38:15Z [Term] id: GO:2000448 name: positive regulation of macrophage migration inhibitory factor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] synonym: "positive regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of MIF signaling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway relationship: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway created_by: rfoulger creation_date: 2011-03-04T10:38:43Z [Term] id: GO:2000449 name: regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000407 ! regulation of T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation relationship: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:41:03Z [Term] id: GO:2000450 name: negative regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000408 ! negative regulation of T cell extravasation is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation relationship: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:41:43Z [Term] id: GO:2000451 name: positive regulation of CD8-positive, alpha-beta T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] is_a: GO:2000409 ! positive regulation of T cell extravasation is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation relationship: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:42:14Z [Term] id: GO:2000452 name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation relationship: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:44:39Z [Term] id: GO:2000453 name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation relationship: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:45:20Z [Term] id: GO:2000454 name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation relationship: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:45:52Z [Term] id: GO:2000455 name: regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035699 ! T-helper 17 cell extravasation relationship: regulates GO:0035699 ! T-helper 17 cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:49:51Z [Term] id: GO:2000456 name: negative regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation relationship: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:50:29Z [Term] id: GO:2000457 name: positive regulation of T-helper 17 cell extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035699 ! T-helper 17 cell extravasation relationship: positively_regulates GO:0035699 ! T-helper 17 cell extravasation created_by: rfoulger creation_date: 2011-03-04T10:51:00Z [Term] id: GO:2000458 name: regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035700 ! astrocyte chemotaxis relationship: regulates GO:0035700 ! astrocyte chemotaxis created_by: rfoulger creation_date: 2011-03-04T10:53:50Z [Term] id: GO:2000459 name: negative regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035700 ! astrocyte chemotaxis relationship: negatively_regulates GO:0035700 ! astrocyte chemotaxis created_by: rfoulger creation_date: 2011-03-04T10:54:28Z [Term] id: GO:2000460 name: obsolete regulation of eukaryotic cell surface binding namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. synonym: "regulation of eukaryotic cell surface binding" EXACT [] is_obsolete: true consider: GO:0031347 consider: GO:1900120 created_by: yaf creation_date: 2011-03-04T11:59:52Z [Term] id: GO:2000461 name: obsolete negative regulation of eukaryotic cell surface binding namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. synonym: "negative regulation of eukaryotic cell surface binding" EXACT [] is_obsolete: true consider: GO:0031347 consider: GO:1900121 created_by: yaf creation_date: 2011-03-04T12:00:26Z [Term] id: GO:2000462 name: obsolete positive regulation of eukaryotic cell surface binding namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. synonym: "positive regulation of eukaryotic cell surface binding" EXACT [] is_obsolete: true consider: GO:0031347 consider: GO:1900122 created_by: yaf creation_date: 2011-03-04T12:00:49Z [Term] id: GO:2000463 name: positive regulation of excitatory postsynaptic potential namespace: biological_process def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF] synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol] synonym: "positive regulation of excitatory post-synaptic membrane potential" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0098815 ! modulation of excitatory postsynaptic potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: positively_regulates GO:0060079 ! excitatory postsynaptic potential relationship: positively_regulates GO:0060079 ! excitatory postsynaptic potential created_by: rl creation_date: 2011-03-04T02:43:32Z [Term] id: GO:2000464 name: positive regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035700 ! astrocyte chemotaxis relationship: positively_regulates GO:0035700 ! astrocyte chemotaxis created_by: rfoulger creation_date: 2011-03-04T04:43:29Z [Term] id: GO:2000465 name: regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004373 ! glycogen (starch) synthase activity relationship: regulates GO:0004373 ! glycogen (starch) synthase activity created_by: yaf creation_date: 2011-03-07T04:12:35Z [Term] id: GO:2000466 name: negative regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "negative regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004373 ! glycogen (starch) synthase activity relationship: negatively_regulates GO:0004373 ! glycogen (starch) synthase activity created_by: yaf creation_date: 2011-03-07T04:13:14Z [Term] id: GO:2000467 name: positive regulation of glycogen (starch) synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] synonym: "positive regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] synonym: "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] synonym: "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004373 ! glycogen (starch) synthase activity relationship: positively_regulates GO:0004373 ! glycogen (starch) synthase activity created_by: yaf creation_date: 2011-03-07T04:13:41Z [Term] id: GO:2000468 name: regulation of peroxidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004601 ! peroxidase activity relationship: regulates GO:0004601 ! peroxidase activity created_by: rfoulger creation_date: 2011-03-08T02:18:18Z [Term] id: GO:2000469 name: negative regulation of peroxidase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "negative regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "negative regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "negative regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:2000468 ! regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004601 ! peroxidase activity relationship: negatively_regulates GO:0004601 ! peroxidase activity created_by: rfoulger creation_date: 2011-03-08T02:18:59Z [Term] id: GO:2000470 name: positive regulation of peroxidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol] synonym: "positive regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] synonym: "positive regulation of oxyperoxidase activity" EXACT [GOC:obol] synonym: "positive regulation of peroxidase reaction" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051353 ! positive regulation of oxidoreductase activity is_a: GO:2000468 ! regulation of peroxidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004601 ! peroxidase activity relationship: positively_regulates GO:0004601 ! peroxidase activity created_by: rfoulger creation_date: 2011-03-08T02:19:25Z [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035701 ! hematopoietic stem cell migration relationship: regulates GO:0035701 ! hematopoietic stem cell migration created_by: rfoulger creation_date: 2011-03-09T09:34:08Z [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035701 ! hematopoietic stem cell migration relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration created_by: rfoulger creation_date: 2011-03-09T09:34:54Z [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035701 ! hematopoietic stem cell migration relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration created_by: rfoulger creation_date: 2011-03-09T09:35:25Z [Term] id: GO:2000474 name: regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] synonym: "regulation of opioid receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038003 ! opioid receptor signaling pathway relationship: regulates GO:0038003 ! opioid receptor signaling pathway created_by: rfoulger creation_date: 2011-03-09T09:40:19Z [Term] id: GO:2000475 name: negative regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] synonym: "negative regulation of opioid receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway is_a: GO:2000474 ! regulation of opioid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038003 ! opioid receptor signaling pathway relationship: negatively_regulates GO:0038003 ! opioid receptor signaling pathway created_by: rfoulger creation_date: 2011-03-09T09:41:03Z [Term] id: GO:2000476 name: positive regulation of opioid receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] synonym: "positive regulation of opioid receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway is_a: GO:2000474 ! regulation of opioid receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038003 ! opioid receptor signaling pathway relationship: positively_regulates GO:0038003 ! opioid receptor signaling pathway created_by: rfoulger creation_date: 2011-03-09T09:41:35Z [Term] id: GO:2000477 name: regulation of metanephric glomerular visceral epithelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "regulation of metanephric podocyte development" RELATED [GOC:obol] is_a: GO:0060284 ! regulation of cell development is_a: GO:0072298 ! regulation of metanephric glomerulus development is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development relationship: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development created_by: yaf creation_date: 2011-03-09T05:16:40Z [Term] id: GO:2000478 name: positive regulation of metanephric glomerular visceral epithelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] synonym: "positive regulation of metanephric podocyte development" RELATED [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0072300 ! positive regulation of metanephric glomerulus development is_a: GO:2000477 ! regulation of metanephric glomerular visceral epithelial cell development is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development relationship: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development created_by: yaf creation_date: 2011-03-09T05:17:26Z [Term] id: GO:2000479 name: regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of AMPK" RELATED [GOC:obol] synonym: "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "regulation of PKA" RELATED [GOC:obol] synonym: "regulation of PKA C" RELATED [GOC:obol] synonym: "regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "regulation of STK22" RELATED [GOC:obol] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004691 ! cAMP-dependent protein kinase activity relationship: regulates GO:0004691 ! cAMP-dependent protein kinase activity created_by: yaf creation_date: 2011-03-10T11:13:01Z [Term] id: GO:2000480 name: negative regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of AMPK" RELATED [GOC:obol] synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "negative regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "negative regulation of PKA" RELATED [GOC:obol] synonym: "negative regulation of PKA C" RELATED [GOC:obol] synonym: "negative regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "negative regulation of STK22" RELATED [GOC:obol] is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity relationship: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity created_by: yaf creation_date: 2011-03-10T11:13:45Z [Term] id: GO:2000481 name: positive regulation of cAMP-dependent protein kinase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] synonym: "positive regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of AMPK" RELATED [GOC:obol] synonym: "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] synonym: "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] synonym: "positive regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] synonym: "positive regulation of PKA" RELATED [GOC:obol] synonym: "positive regulation of PKA C" RELATED [GOC:obol] synonym: "positive regulation of protein kinase A activity" RELATED [GOC:obol] synonym: "positive regulation of STK22" RELATED [GOC:obol] is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004691 ! cAMP-dependent protein kinase activity relationship: positively_regulates GO:0004691 ! cAMP-dependent protein kinase activity created_by: yaf creation_date: 2011-03-10T11:14:17Z [Term] id: GO:2000482 name: regulation of interleukin-8 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0032677 ! regulation of interleukin-8 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072606 ! interleukin-8 secretion relationship: regulates GO:0072606 ! interleukin-8 secretion created_by: yaf creation_date: 2011-03-10T02:37:11Z [Term] id: GO:2000483 name: negative regulation of interleukin-8 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "negative regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0032717 ! negative regulation of interleukin-8 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000482 ! regulation of interleukin-8 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072606 ! interleukin-8 secretion relationship: negatively_regulates GO:0072606 ! interleukin-8 secretion created_by: yaf creation_date: 2011-03-10T02:37:51Z [Term] id: GO:2000484 name: positive regulation of interleukin-8 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] synonym: "positive regulation of IL-8 secretion" EXACT [GOC:obol] is_a: GO:0032757 ! positive regulation of interleukin-8 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000482 ! regulation of interleukin-8 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072606 ! interleukin-8 secretion relationship: positively_regulates GO:0072606 ! interleukin-8 secretion created_by: yaf creation_date: 2011-03-10T02:38:20Z [Term] id: GO:2000485 name: regulation of glutamine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006868 ! glutamine transport relationship: regulates GO:0006868 ! glutamine transport created_by: rfoulger creation_date: 2011-03-11T09:32:23Z [Term] id: GO:2000486 name: negative regulation of glutamine transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "negative regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:2000485 ! regulation of glutamine transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006868 ! glutamine transport relationship: negatively_regulates GO:0006868 ! glutamine transport created_by: rfoulger creation_date: 2011-03-11T09:33:07Z [Term] id: GO:2000487 name: positive regulation of glutamine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol] synonym: "positive regulation of L-glutamine transport" RELATED [GOC:obol] is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:2000485 ! regulation of glutamine transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006868 ! glutamine transport relationship: positively_regulates GO:0006868 ! glutamine transport created_by: rfoulger creation_date: 2011-03-11T09:33:39Z [Term] id: GO:2000488 name: positive regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol] synonym: "positive regulation of brassinosteroid anabolism" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid formation" EXACT [GOC:obol] synonym: "positive regulation of brassinosteroid synthesis" EXACT [GOC:obol] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0010893 ! positive regulation of steroid biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process relationship: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process created_by: dhl creation_date: 2011-03-11T06:48:45Z [Term] id: GO:2000489 name: regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035733 ! hepatic stellate cell activation relationship: regulates GO:0035733 ! hepatic stellate cell activation created_by: rfoulger creation_date: 2011-03-14T03:48:32Z [Term] id: GO:2000490 name: negative regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035733 ! hepatic stellate cell activation relationship: negatively_regulates GO:0035733 ! hepatic stellate cell activation created_by: rfoulger creation_date: 2011-03-14T03:49:18Z [Term] id: GO:2000491 name: positive regulation of hepatic stellate cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:2000489 ! regulation of hepatic stellate cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035733 ! hepatic stellate cell activation relationship: positively_regulates GO:0035733 ! hepatic stellate cell activation created_by: rfoulger creation_date: 2011-03-14T03:49:48Z [Term] id: GO:2000492 name: regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035655 ! interleukin-18-mediated signaling pathway relationship: regulates GO:0035655 ! interleukin-18-mediated signaling pathway created_by: pr creation_date: 2011-03-16T01:59:18Z [Term] id: GO:2000493 name: negative regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "negative regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway relationship: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway created_by: pr creation_date: 2011-03-16T02:00:12Z [Term] id: GO:2000494 name: positive regulation of interleukin-18-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] synonym: "positive regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway relationship: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway created_by: pr creation_date: 2011-03-16T02:00:50Z [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis created_by: rfoulger creation_date: 2011-03-18T02:18:34Z [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis created_by: rfoulger creation_date: 2011-03-18T02:19:22Z [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis created_by: rfoulger creation_date: 2011-03-18T02:19:54Z [Term] id: GO:2000498 name: obsolete regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] comment: This term was made obsolete because it is ill-defined. synonym: "regulation of induction of apoptosis in response to chemical stimulus" EXACT [] synonym: "regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_obsolete: true created_by: yaf creation_date: 2011-03-18T02:34:53Z [Term] id: GO:2000499 name: obsolete negative regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] comment: This term was made obsolete because it is ill-defined. synonym: "negative regulation of induction of apoptosis in response to chemical stimulus" EXACT [] synonym: "negative regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_obsolete: true created_by: yaf creation_date: 2011-03-18T02:35:44Z [Term] id: GO:2000500 name: obsolete positive regulation of induction of apoptosis in response to chemical stimulus namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] comment: This term was made obsolete because it is ill-defined. synonym: "positive regulation of induction of apoptosis in response to chemical stimulus" EXACT [] synonym: "positive regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] is_obsolete: true created_by: yaf creation_date: 2011-03-18T02:36:22Z [Term] id: GO:2000501 name: regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035747 ! natural killer cell chemotaxis relationship: regulates GO:0035747 ! natural killer cell chemotaxis created_by: rfoulger creation_date: 2011-03-21T10:09:23Z [Term] id: GO:2000502 name: negative regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis is_a: GO:2000501 ! regulation of natural killer cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035747 ! natural killer cell chemotaxis relationship: negatively_regulates GO:0035747 ! natural killer cell chemotaxis created_by: rfoulger creation_date: 2011-03-21T10:09:32Z [Term] id: GO:2000503 name: positive regulation of natural killer cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000501 ! regulation of natural killer cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035747 ! natural killer cell chemotaxis relationship: positively_regulates GO:0035747 ! natural killer cell chemotaxis created_by: rfoulger creation_date: 2011-03-21T10:09:38Z [Term] id: GO:2000504 name: positive regulation of blood vessel remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0060312 ! regulation of blood vessel remodeling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001974 ! blood vessel remodeling relationship: positively_regulates GO:0001974 ! blood vessel remodeling created_by: pr creation_date: 2011-03-21T10:33:20Z [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002407 ! dendritic cell chemotaxis relationship: regulates GO:0002407 ! dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-22T10:21:38Z [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002407 ! dendritic cell chemotaxis relationship: negatively_regulates GO:0002407 ! dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-22T10:21:45Z [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002407 ! dendritic cell chemotaxis relationship: positively_regulates GO:0002407 ! dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-22T10:21:49Z [Term] id: GO:2000511 name: regulation of granzyme A production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035746 ! granzyme A production relationship: regulates GO:0035746 ! granzyme A production created_by: ebc creation_date: 2011-03-22T10:31:27Z [Term] id: GO:2000512 name: negative regulation of granzyme A production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:2000511 ! regulation of granzyme A production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035746 ! granzyme A production relationship: negatively_regulates GO:0035746 ! granzyme A production created_by: ebc creation_date: 2011-03-22T10:31:32Z [Term] id: GO:2000513 name: positive regulation of granzyme A production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:2000511 ! regulation of granzyme A production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035746 ! granzyme A production relationship: positively_regulates GO:0035746 ! granzyme A production created_by: ebc creation_date: 2011-03-22T10:31:36Z [Term] id: GO:2000514 name: regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation relationship: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation created_by: ebc creation_date: 2011-03-22T10:36:56Z [Term] id: GO:2000515 name: negative regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation relationship: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation created_by: ebc creation_date: 2011-03-22T10:37:02Z [Term] id: GO:2000516 name: positive regulation of CD4-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation relationship: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation created_by: ebc creation_date: 2011-03-22T10:37:06Z [Term] id: GO:2000517 name: regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035711 ! T-helper 1 cell activation relationship: regulates GO:0035711 ! T-helper 1 cell activation created_by: ebc creation_date: 2011-03-22T10:40:19Z [Term] id: GO:2000518 name: negative regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035711 ! T-helper 1 cell activation relationship: negatively_regulates GO:0035711 ! T-helper 1 cell activation created_by: ebc creation_date: 2011-03-22T10:40:26Z [Term] id: GO:2000519 name: positive regulation of T-helper 1 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000517 ! regulation of T-helper 1 cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035711 ! T-helper 1 cell activation relationship: positively_regulates GO:0035711 ! T-helper 1 cell activation created_by: ebc creation_date: 2011-03-22T10:40:31Z [Term] id: GO:2000520 name: regulation of immunological synapse formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001771 ! immunological synapse formation relationship: regulates GO:0001771 ! immunological synapse formation created_by: ebc creation_date: 2011-03-23T10:18:14Z [Term] id: GO:2000521 name: negative regulation of immunological synapse formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "negative regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:2000520 ! regulation of immunological synapse formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001771 ! immunological synapse formation relationship: negatively_regulates GO:0001771 ! immunological synapse formation created_by: ebc creation_date: 2011-03-23T10:18:19Z [Term] id: GO:2000522 name: positive regulation of immunological synapse formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol] synonym: "positive regulation of formation of immunological synapse" EXACT [GOC:obol] is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:2000520 ! regulation of immunological synapse formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001771 ! immunological synapse formation relationship: positively_regulates GO:0001771 ! immunological synapse formation created_by: ebc creation_date: 2011-03-23T10:18:23Z [Term] id: GO:2000523 name: regulation of T cell costimulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031295 ! T cell costimulation relationship: regulates GO:0031295 ! T cell costimulation created_by: ebc creation_date: 2011-03-23T10:23:24Z [Term] id: GO:2000524 name: negative regulation of T cell costimulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:2000523 ! regulation of T cell costimulation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031295 ! T cell costimulation relationship: negatively_regulates GO:0031295 ! T cell costimulation created_by: ebc creation_date: 2011-03-23T10:23:31Z [Term] id: GO:2000525 name: positive regulation of T cell costimulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol] synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol] synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2000523 ! regulation of T cell costimulation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031295 ! T cell costimulation relationship: positively_regulates GO:0031295 ! T cell costimulation created_by: ebc creation_date: 2011-03-23T10:23:36Z [Term] id: GO:2000526 name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation namespace: biological_process def: "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol] synonym: "positive regulation of glycoprotein biosynthetic process of formation of immunological synapse" EXACT [GOC:obol] synonym: "positive regulation of glycoprotein biosynthetic process of immunological synapse formation" EXACT [GOC:obol] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process intersection_of: GO:0010560 ! positive regulation of glycoprotein biosynthetic process intersection_of: part_of GO:0001771 ! immunological synapse formation relationship: part_of GO:0001771 ! immunological synapse formation created_by: ebc creation_date: 2011-03-23T10:42:30Z [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002408 ! myeloid dendritic cell chemotaxis relationship: regulates GO:0002408 ! myeloid dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-23T12:18:32Z [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis relationship: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-23T12:18:39Z [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis relationship: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis created_by: ebc creation_date: 2011-03-23T12:18:45Z [Term] id: GO:2000530 name: obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol] synonym: "positive regulation of regulation of insulin secretion in response to glucose" EXACT [GOC:obol] synonym: "positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus" EXACT [] is_obsolete: true created_by: yaf creation_date: 2011-03-24T09:27:37Z [Term] id: GO:2000531 name: obsolete regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:vw] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true created_by: dph creation_date: 2011-03-24T12:18:33Z [Term] id: GO:2000532 name: regulation of renal albumin absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097018 ! renal albumin absorption relationship: regulates GO:0097018 ! renal albumin absorption created_by: pr creation_date: 2011-03-24T03:28:06Z [Term] id: GO:2000533 name: negative regulation of renal albumin absorption namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000532 ! regulation of renal albumin absorption intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097018 ! renal albumin absorption relationship: negatively_regulates GO:0097018 ! renal albumin absorption created_by: pr creation_date: 2011-03-24T03:28:11Z [Term] id: GO:2000534 name: positive regulation of renal albumin absorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000532 ! regulation of renal albumin absorption intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097018 ! renal albumin absorption relationship: positively_regulates GO:0097018 ! renal albumin absorption created_by: pr creation_date: 2011-03-24T03:28:14Z [Term] id: GO:2000535 name: regulation of entry of bacterium into host cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] synonym: "regulation of bacterial entry into host cell" EXACT [GOC:obol] synonym: "regulation of invasion of bacteria into host cell" EXACT [GOC:obol] is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035635 ! entry of bacterium into host cell relationship: regulates GO:0035635 ! entry of bacterium into host cell created_by: ebc creation_date: 2011-03-28T09:52:16Z [Term] id: GO:2000536 name: negative regulation of entry of bacterium into host cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] synonym: "negative regulation of bacterial entry into host cell" EXACT [GOC:obol] synonym: "negative regulation of invasion of bacteria into host cell" EXACT [GOC:obol] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:2000535 ! regulation of entry of bacterium into host cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035635 ! entry of bacterium into host cell relationship: negatively_regulates GO:0035635 ! entry of bacterium into host cell created_by: ebc creation_date: 2011-03-28T09:52:23Z [Term] id: GO:2000537 name: regulation of B cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035754 ! B cell chemotaxis relationship: regulates GO:0035754 ! B cell chemotaxis created_by: ebc creation_date: 2011-03-29T09:49:25Z [Term] id: GO:2000538 name: positive regulation of B cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000537 ! regulation of B cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035754 ! B cell chemotaxis relationship: positively_regulates GO:0035754 ! B cell chemotaxis created_by: ebc creation_date: 2011-03-29T09:49:33Z [Term] id: GO:2000539 name: regulation of protein geranylgeranylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018344 ! protein geranylgeranylation relationship: regulates GO:0018344 ! protein geranylgeranylation created_by: tanyaberardini creation_date: 2011-03-29T06:23:05Z [Term] id: GO:2000540 name: negative regulation of protein geranylgeranylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "negative regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "negative regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:2000539 ! regulation of protein geranylgeranylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018344 ! protein geranylgeranylation relationship: negatively_regulates GO:0018344 ! protein geranylgeranylation created_by: tanyaberardini creation_date: 2011-03-29T06:23:11Z [Term] id: GO:2000541 name: positive regulation of protein geranylgeranylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] synonym: "positive regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] synonym: "positive regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:2000539 ! regulation of protein geranylgeranylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018344 ! protein geranylgeranylation relationship: positively_regulates GO:0018344 ! protein geranylgeranylation created_by: tanyaberardini creation_date: 2011-03-29T06:23:15Z [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007369 ! gastrulation relationship: negatively_regulates GO:0007369 ! gastrulation created_by: yaf creation_date: 2011-04-01T04:10:08Z [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007369 ! gastrulation relationship: positively_regulates GO:0007369 ! gastrulation created_by: yaf creation_date: 2011-04-01T04:10:15Z [Term] id: GO:2000544 name: regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor relationship: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor created_by: ebc creation_date: 2011-04-03T07:14:04Z [Term] id: GO:2000545 name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:1904848 ! negative regulation of cell chemotaxis to fibroblast growth factor is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor is_a: GO:2001027 ! negative regulation of endothelial cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor relationship: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor created_by: ebc creation_date: 2011-04-03T07:14:11Z [Term] id: GO:2000546 name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] is_a: GO:1904849 ! positive regulation of cell chemotaxis to fibroblast growth factor is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor relationship: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor created_by: ebc creation_date: 2011-04-03T07:17:27Z [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097026 ! dendritic cell dendrite assembly relationship: regulates GO:0097026 ! dendritic cell dendrite assembly created_by: ebc creation_date: 2011-04-03T07:21:55Z [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "negative regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly created_by: ebc creation_date: 2011-04-03T07:22:01Z [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "positive regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097026 ! dendritic cell dendrite assembly relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly created_by: ebc creation_date: 2011-04-03T07:22:06Z [Term] id: GO:2000550 name: negative regulation of B cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol] is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis is_a: GO:2000537 ! regulation of B cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035754 ! B cell chemotaxis relationship: negatively_regulates GO:0035754 ! B cell chemotaxis created_by: ebc creation_date: 2011-04-03T07:25:59Z [Term] id: GO:2000551 name: regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002828 ! regulation of type 2 immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035745 ! T-helper 2 cell cytokine production relationship: regulates GO:0035745 ! T-helper 2 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:32:47Z [Term] id: GO:2000552 name: negative regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:0002829 ! negative regulation of type 2 immune response is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production relationship: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:32:54Z [Term] id: GO:2000553 name: positive regulation of T-helper 2 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:0002830 ! positive regulation of type 2 immune response is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production relationship: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:32:58Z [Term] id: GO:2000554 name: regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002724 ! regulation of T cell cytokine production is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035744 ! T-helper 1 cell cytokine production relationship: regulates GO:0035744 ! T-helper 1 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:35:43Z [Term] id: GO:2000555 name: negative regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002725 ! negative regulation of T cell cytokine production is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production relationship: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:35:51Z [Term] id: GO:2000556 name: positive regulation of T-helper 1 cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol] is_a: GO:0002726 ! positive regulation of T cell cytokine production is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production relationship: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production created_by: ebc creation_date: 2011-04-03T07:35:56Z [Term] id: GO:2000557 name: regulation of immunoglobulin production in mucosal tissue namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] synonym: "regulation of antibody production in mucosal tissue" EXACT [GOC:obol] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002426 ! immunoglobulin production in mucosal tissue relationship: regulates GO:0002426 ! immunoglobulin production in mucosal tissue created_by: ebc creation_date: 2011-04-03T07:52:09Z [Term] id: GO:2000558 name: positive regulation of immunoglobulin production in mucosal tissue namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] synonym: "positive regulation of antibody production in mucosal tissue" EXACT [GOC:obol] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:2000557 ! regulation of immunoglobulin production in mucosal tissue intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue relationship: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue created_by: ebc creation_date: 2011-04-03T07:52:17Z [Term] id: GO:2000559 name: regulation of CD24 biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol] synonym: "regulation of CD24 formation" EXACT [GOC:obol] synonym: "regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035724 ! CD24 biosynthetic process relationship: regulates GO:0035724 ! CD24 biosynthetic process created_by: ebc creation_date: 2011-04-03T08:56:56Z [Term] id: GO:2000560 name: positive regulation of CD24 biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of CD24 formation" EXACT [GOC:obol] synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process is_a: GO:2000559 ! regulation of CD24 biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035724 ! CD24 biosynthetic process relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process created_by: ebc creation_date: 2011-04-03T08:57:02Z [Term] id: GO:2000561 name: regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation relationship: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:01:04Z [Term] id: GO:2000562 name: negative regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation relationship: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:01:11Z [Term] id: GO:2000563 name: positive regulation of CD4-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation relationship: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:01:15Z [Term] id: GO:2000564 name: regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation relationship: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:03:13Z [Term] id: GO:2000565 name: negative regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation relationship: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:03:19Z [Term] id: GO:2000566 name: positive regulation of CD8-positive, alpha-beta T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation relationship: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation created_by: ebc creation_date: 2011-04-03T09:03:24Z [Term] id: GO:2000567 name: regulation of memory T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035709 ! memory T cell activation relationship: regulates GO:0035709 ! memory T cell activation created_by: ebc creation_date: 2011-04-03T09:10:06Z [Term] id: GO:2000568 name: positive regulation of memory T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2000567 ! regulation of memory T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035709 ! memory T cell activation relationship: positively_regulates GO:0035709 ! memory T cell activation created_by: ebc creation_date: 2011-04-03T09:10:12Z [Term] id: GO:2000569 name: regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035712 ! T-helper 2 cell activation relationship: regulates GO:0035712 ! T-helper 2 cell activation created_by: ebc creation_date: 2011-04-03T09:14:53Z [Term] id: GO:2000570 name: positive regulation of T-helper 2 cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol] is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation is_a: GO:2000569 ! regulation of T-helper 2 cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035712 ! T-helper 2 cell activation relationship: positively_regulates GO:0035712 ! T-helper 2 cell activation created_by: ebc creation_date: 2011-04-03T09:14:59Z [Term] id: GO:2000571 name: regulation of interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] synonym: "regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes relationship: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes created_by: ebc creation_date: 2011-04-03T09:20:11Z [Term] id: GO:2000572 name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] synonym: "positive regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] is_a: GO:0048295 ! positive regulation of isotype switching to IgE isotypes is_a: GO:2000571 ! regulation of interleukin-4-dependent isotype switching to IgE isotypes intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes relationship: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes created_by: ebc creation_date: 2011-04-03T09:20:18Z [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of DNA formation" EXACT [GOC:obol] synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process relationship: positively_regulates GO:0071897 ! DNA biosynthetic process created_by: yaf creation_date: 2011-04-04T10:01:20Z [Term] id: GO:2000574 name: regulation of microtubule motor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "regulation of dynein" RELATED [GOC:obol] synonym: "regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "regulation of kinesin" RELATED [GOC:obol] synonym: "regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003777 ! microtubule motor activity relationship: regulates GO:0003777 ! microtubule motor activity created_by: rfoulger creation_date: 2011-04-05T08:36:44Z [Term] id: GO:2000575 name: negative regulation of microtubule motor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "negative regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "negative regulation of dynein" RELATED [GOC:obol] synonym: "negative regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "negative regulation of kinesin" RELATED [GOC:obol] synonym: "negative regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "negative regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:2000574 ! regulation of microtubule motor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003777 ! microtubule motor activity relationship: negatively_regulates GO:0003777 ! microtubule motor activity created_by: rfoulger creation_date: 2011-04-05T08:36:48Z [Term] id: GO:2000576 name: positive regulation of microtubule motor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv] synonym: "positive regulation of axonemal motor activity" RELATED [GOC:obol] synonym: "positive regulation of dynein" RELATED [GOC:obol] synonym: "positive regulation of dynein ATPase activity" RELATED [GOC:obol] synonym: "positive regulation of kinesin" RELATED [GOC:obol] synonym: "positive regulation of kinesin motor activity" RELATED [GOC:obol] synonym: "positive regulation of kinetochore motor activity" RELATED [GOC:obol] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:2000574 ! regulation of microtubule motor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003777 ! microtubule motor activity relationship: positively_regulates GO:0003777 ! microtubule motor activity created_by: rfoulger creation_date: 2011-04-05T08:36:51Z [Term] id: GO:2000577 name: regulation of ATP-dependent microtubule motor activity, minus-end-directed namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] synonym: "regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol] synonym: "regulation of minus-end-directed microtubule motor activity" BROAD [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:2000574 ! regulation of microtubule motor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed relationship: regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:37:52Z [Term] id: GO:2000578 name: negative regulation of ATP-dependent microtubule motor activity, minus-end-directed namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] synonym: "negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "negative regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol] synonym: "negative regulation of minus-end-directed microtubule motor activity" BROAD [] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:2000575 ! negative regulation of microtubule motor activity is_a: GO:2000577 ! regulation of ATP-dependent microtubule motor activity, minus-end-directed intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed relationship: negatively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:37:57Z [Term] id: GO:2000579 name: positive regulation of ATP-dependent microtubule motor activity, minus-end-directed namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] synonym: "positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] synonym: "positive regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol] synonym: "positive regulation of minus-end-directed microtubule motor activity" BROAD [] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:2000576 ! positive regulation of microtubule motor activity is_a: GO:2000577 ! regulation of ATP-dependent microtubule motor activity, minus-end-directed intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed relationship: positively_regulates GO:0008569 ! ATP-dependent microtubule motor activity, minus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:38:01Z [Term] id: GO:2000580 name: regulation of ATP-dependent microtubule motor activity, plus-end-directed namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] synonym: "regulation of kinesin activity" RELATED [GOC:obol] synonym: "regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] synonym: "regulation of plus-end-directed microtubule motor activity" BROAD [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:2000574 ! regulation of microtubule motor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed relationship: regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:39:43Z [Term] id: GO:2000581 name: negative regulation of ATP-dependent microtubule motor activity, plus-end-directed namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] synonym: "negative regulation of kinesin activity" RELATED [GOC:obol] synonym: "negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "negative regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] synonym: "negative regulation of plus-end-directed microtubule motor activity" BROAD [] is_a: GO:0032780 ! negative regulation of ATPase activity is_a: GO:2000575 ! negative regulation of microtubule motor activity is_a: GO:2000580 ! regulation of ATP-dependent microtubule motor activity, plus-end-directed intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed relationship: negatively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:39:49Z [Term] id: GO:2000582 name: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] synonym: "positive regulation of kinesin activity" RELATED [GOC:obol] synonym: "positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] synonym: "positive regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] synonym: "positive regulation of plus-end-directed microtubule motor activity" BROAD [] is_a: GO:0032781 ! positive regulation of ATPase activity is_a: GO:2000576 ! positive regulation of microtubule motor activity is_a: GO:2000580 ! regulation of ATP-dependent microtubule motor activity, plus-end-directed intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed relationship: positively_regulates GO:0008574 ! ATP-dependent microtubule motor activity, plus-end-directed created_by: rfoulger creation_date: 2011-04-05T08:39:52Z [Term] id: GO:2000583 name: regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] synonym: "regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] synonym: "regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway relationship: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:26:25Z [Term] id: GO:2000584 name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol, GOC:yaf] synonym: "negative regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway relationship: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:26:31Z [Term] id: GO:2000585 name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] synonym: "positive regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway relationship: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:26:35Z [Term] id: GO:2000586 name: regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] synonym: "regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway relationship: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:27:48Z [Term] id: GO:2000587 name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "negative regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway relationship: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:27:54Z [Term] id: GO:2000588 name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] synonym: "positive regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway relationship: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway created_by: rfoulger creation_date: 2011-04-07T03:27:58Z [Term] id: GO:2000589 name: regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] synonym: "regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0072215 ! regulation of metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035789 ! metanephric mesenchymal cell migration relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration created_by: rfoulger creation_date: 2011-04-07T03:29:43Z [Term] id: GO:2000590 name: negative regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] synonym: "negative regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration relationship: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration created_by: rfoulger creation_date: 2011-04-07T03:29:49Z [Term] id: GO:2000591 name: positive regulation of metanephric mesenchymal cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "positive regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration created_by: rfoulger creation_date: 2011-04-07T03:29:53Z [Term] id: GO:2000592 name: regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0072215 ! regulation of metanephros development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072240 ! metanephric DCT cell differentiation relationship: regulates GO:0072240 ! metanephric DCT cell differentiation created_by: yaf creation_date: 2011-04-11T01:40:33Z [Term] id: GO:2000593 name: negative regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "negative regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation relationship: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation created_by: yaf creation_date: 2011-04-11T01:40:38Z [Term] id: GO:2000594 name: positive regulation of metanephric DCT cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] synonym: "positive regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072240 ! metanephric DCT cell differentiation relationship: positively_regulates GO:0072240 ! metanephric DCT cell differentiation created_by: yaf creation_date: 2011-04-11T01:40:41Z [Term] id: GO:2000595 name: regulation of optic nerve formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0021634 ! optic nerve formation relationship: regulates GO:0021634 ! optic nerve formation created_by: yaf creation_date: 2011-04-11T03:41:30Z [Term] id: GO:2000596 name: negative regulation of optic nerve formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "negative regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:2000595 ! regulation of optic nerve formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021634 ! optic nerve formation relationship: negatively_regulates GO:0021634 ! optic nerve formation created_by: yaf creation_date: 2011-04-11T03:41:35Z [Term] id: GO:2000597 name: positive regulation of optic nerve formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol] synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol] synonym: "positive regulation of CN II formation" RELATED [GOC:obol] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:2000595 ! regulation of optic nerve formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0021634 ! optic nerve formation relationship: positively_regulates GO:0021634 ! optic nerve formation created_by: yaf creation_date: 2011-04-11T03:41:39Z [Term] id: GO:2000601 name: positive regulation of Arp2/3 complex-mediated actin nucleation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] synonym: "positive regulation of actin filament branch nucleation" EXACT [GOC:obol] synonym: "positive regulation of branched actin filament nucleation" EXACT [GOC:obol] is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation is_a: GO:0051127 ! positive regulation of actin nucleation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation relationship: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation created_by: rfoulger creation_date: 2011-04-14T12:35:44Z [Term] id: GO:2000602 name: obsolete regulation of interphase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "regulation of interphase of mitotic cell cycle" EXACT [] is_obsolete: true created_by: pr creation_date: 2011-04-15T03:52:25Z [Term] id: GO:2000603 name: regulation of secondary growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0040008 ! regulation of growth intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080117 ! secondary growth relationship: regulates GO:0080117 ! secondary growth created_by: tanyaberardini creation_date: 2011-04-15T10:30:44Z [Term] id: GO:2000604 name: negative regulation of secondary growth namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0045926 ! negative regulation of growth is_a: GO:2000603 ! regulation of secondary growth intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0080117 ! secondary growth relationship: negatively_regulates GO:0080117 ! secondary growth created_by: tanyaberardini creation_date: 2011-04-15T10:30:47Z [Term] id: GO:2000605 name: positive regulation of secondary growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol] is_a: GO:0045927 ! positive regulation of growth is_a: GO:2000603 ! regulation of secondary growth intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0080117 ! secondary growth relationship: positively_regulates GO:0080117 ! secondary growth created_by: tanyaberardini creation_date: 2011-04-15T10:30:49Z [Term] id: GO:2000606 name: regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061209 ! cell proliferation involved in mesonephros development relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development created_by: yaf creation_date: 2011-04-18T08:42:19Z [Term] id: GO:2000607 name: negative regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development created_by: yaf creation_date: 2011-04-18T08:42:23Z [Term] id: GO:2000608 name: positive regulation of cell proliferation involved in mesonephros development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development created_by: yaf creation_date: 2011-04-18T08:42:25Z [Term] id: GO:2000609 name: regulation of thyroid hormone generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006590 ! thyroid hormone generation relationship: regulates GO:0006590 ! thyroid hormone generation created_by: yaf creation_date: 2011-04-18T10:12:14Z [Term] id: GO:2000610 name: negative regulation of thyroid hormone generation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006590 ! thyroid hormone generation relationship: negatively_regulates GO:0006590 ! thyroid hormone generation created_by: yaf creation_date: 2011-04-18T10:12:19Z [Term] id: GO:2000611 name: positive regulation of thyroid hormone generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:2000609 ! regulation of thyroid hormone generation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006590 ! thyroid hormone generation relationship: positively_regulates GO:0006590 ! thyroid hormone generation created_by: yaf creation_date: 2011-04-18T10:12:22Z [Term] id: GO:2000612 name: regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070460 ! thyroid-stimulating hormone secretion relationship: regulates GO:0070460 ! thyroid-stimulating hormone secretion created_by: yaf creation_date: 2011-04-18T12:56:16Z [Term] id: GO:2000613 name: negative regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "negative regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion relationship: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion created_by: yaf creation_date: 2011-04-18T12:56:20Z [Term] id: GO:2000614 name: positive regulation of thyroid-stimulating hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] synonym: "positive regulation of TSH secretion" EXACT [GOC:obol] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion relationship: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion created_by: yaf creation_date: 2011-04-18T12:56:22Z [Term] id: GO:2000615 name: regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035065 ! regulation of histone acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043970 ! histone H3-K9 acetylation relationship: regulates GO:0043970 ! histone H3-K9 acetylation created_by: vk creation_date: 2011-04-18T03:15:59Z [Term] id: GO:2000616 name: negative regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "negative regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "negative regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035067 ! negative regulation of histone acetylation is_a: GO:2000615 ! regulation of histone H3-K9 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043970 ! histone H3-K9 acetylation relationship: negatively_regulates GO:0043970 ! histone H3-K9 acetylation created_by: vk creation_date: 2011-04-18T03:16:04Z [Term] id: GO:2000617 name: positive regulation of histone H3-K9 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] synonym: "positive regulation of histone H3 acetylation at K9" EXACT [GOC:obol] synonym: "positive regulation of histone H3K9 acetylation" EXACT [GOC:obol] is_a: GO:0035066 ! positive regulation of histone acetylation is_a: GO:2000615 ! regulation of histone H3-K9 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043970 ! histone H3-K9 acetylation relationship: positively_regulates GO:0043970 ! histone H3-K9 acetylation created_by: vk creation_date: 2011-04-18T03:16:07Z [Term] id: GO:2000618 name: regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090239 ! regulation of histone H4 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043984 ! histone H4-K16 acetylation relationship: regulates GO:0043984 ! histone H4-K16 acetylation created_by: vk creation_date: 2011-04-18T03:19:23Z [Term] id: GO:2000619 name: negative regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "negative regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090241 ! negative regulation of histone H4 acetylation is_a: GO:2000618 ! regulation of histone H4-K16 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043984 ! histone H4-K16 acetylation relationship: negatively_regulates GO:0043984 ! histone H4-K16 acetylation created_by: vk creation_date: 2011-04-18T03:19:27Z [Term] id: GO:2000620 name: positive regulation of histone H4-K16 acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] synonym: "positive regulation of histone H4 acetylation at K16" EXACT [GOC:obol] is_a: GO:0090240 ! positive regulation of histone H4 acetylation is_a: GO:2000618 ! regulation of histone H4-K16 acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043984 ! histone H4-K16 acetylation relationship: positively_regulates GO:0043984 ! histone H4-K16 acetylation created_by: vk creation_date: 2011-04-18T03:19:30Z [Term] id: GO:2000621 name: regulation of DNA replication termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006274 ! DNA replication termination relationship: regulates GO:0006274 ! DNA replication termination created_by: pr creation_date: 2011-04-18T03:26:23Z [Term] id: GO:2000622 name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:0061013 ! regulation of mRNA catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay created_by: pr creation_date: 2011-04-18T03:32:42Z [Term] id: GO:2000623 name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "negative regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "negative regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "negative regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "negative regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "negative regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:1902373 ! negative regulation of mRNA catabolic process is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay created_by: pr creation_date: 2011-04-18T03:32:46Z [Term] id: GO:2000624 name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] synonym: "positive regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] synonym: "positive regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] synonym: "positive regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] synonym: "positive regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] synonym: "positive regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] synonym: "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] is_a: GO:0061014 ! positive regulation of mRNA catabolic process is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay created_by: pr creation_date: 2011-04-18T03:32:49Z [Term] id: GO:2000625 name: regulation of miRNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010587 ! miRNA catabolic process relationship: regulates GO:0010587 ! miRNA catabolic process created_by: dph creation_date: 2011-04-18T03:46:35Z [Term] id: GO:2000626 name: negative regulation of miRNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "negative regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:1902369 ! negative regulation of RNA catabolic process is_a: GO:2000625 ! regulation of miRNA catabolic process is_a: GO:2000629 ! negative regulation of miRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010587 ! miRNA catabolic process relationship: negatively_regulates GO:0010587 ! miRNA catabolic process created_by: dph creation_date: 2011-04-18T03:46:39Z [Term] id: GO:2000627 name: positive regulation of miRNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph] synonym: "positive regulation of microRNA catabolic process" EXACT [GOC:obol] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000625 ! regulation of miRNA catabolic process is_a: GO:2000630 ! positive regulation of miRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010587 ! miRNA catabolic process relationship: positively_regulates GO:0010587 ! miRNA catabolic process created_by: dph creation_date: 2011-04-18T03:46:42Z [Term] id: GO:2000628 name: regulation of miRNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010586 ! miRNA metabolic process relationship: regulates GO:0010586 ! miRNA metabolic process created_by: dph creation_date: 2011-04-18T03:47:54Z [Term] id: GO:2000629 name: negative regulation of miRNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "negative regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010586 ! miRNA metabolic process relationship: negatively_regulates GO:0010586 ! miRNA metabolic process created_by: dph creation_date: 2011-04-18T03:47:58Z [Term] id: GO:2000630 name: positive regulation of miRNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] synonym: "positive regulation of microRNA metabolic process" EXACT [GOC:obol] is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2000628 ! regulation of miRNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010586 ! miRNA metabolic process relationship: positively_regulates GO:0010586 ! miRNA metabolic process created_by: dph creation_date: 2011-04-18T03:48:01Z [Term] id: GO:2000631 name: regulation of pre-miRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] synonym: "regulation of pre-microRNA processing" EXACT [] is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031054 ! pre-miRNA processing relationship: regulates GO:0031054 ! pre-miRNA processing created_by: dph creation_date: 2011-04-18T03:50:16Z [Term] id: GO:2000632 name: negative regulation of pre-miRNA processing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] synonym: "negative regulation of pre-microRNA processing" EXACT [GOC:obol] is_a: GO:1903799 ! negative regulation of production of miRNAs involved in gene silencing by miRNA is_a: GO:2000631 ! regulation of pre-miRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031054 ! pre-miRNA processing relationship: negatively_regulates GO:0031054 ! pre-miRNA processing created_by: dph creation_date: 2011-04-18T03:50:19Z [Term] id: GO:2000633 name: positive regulation of pre-miRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] synonym: "positive regulation of pre-microRNA processing" EXACT [GOC:obol] is_a: GO:1903800 ! positive regulation of production of miRNAs involved in gene silencing by miRNA is_a: GO:2000631 ! regulation of pre-miRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031054 ! pre-miRNA processing relationship: positively_regulates GO:0031054 ! pre-miRNA processing created_by: dph creation_date: 2011-04-18T03:50:22Z [Term] id: GO:2000634 name: regulation of primary miRNA processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] synonym: "regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "regulation of primary microRNA processing" EXACT [GOC:obol] is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031053 ! primary miRNA processing relationship: regulates GO:0031053 ! primary miRNA processing created_by: dph creation_date: 2011-04-18T03:50:50Z [Term] id: GO:2000635 name: negative regulation of primary miRNA processing namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] synonym: "negative regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "negative regulation of primary microRNA processing" EXACT [GOC:obol] is_a: GO:1903799 ! negative regulation of production of miRNAs involved in gene silencing by miRNA is_a: GO:2000634 ! regulation of primary miRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0031053 ! primary miRNA processing relationship: negatively_regulates GO:0031053 ! primary miRNA processing created_by: dph creation_date: 2011-04-18T03:50:53Z [Term] id: GO:2000636 name: positive regulation of primary miRNA processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] synonym: "positive regulation of pri-miRNA processing" EXACT [GOC:obol] synonym: "positive regulation of primary microRNA processing" EXACT [GOC:obol] is_a: GO:1903800 ! positive regulation of production of miRNAs involved in gene silencing by miRNA is_a: GO:2000634 ! regulation of primary miRNA processing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0031053 ! primary miRNA processing relationship: positively_regulates GO:0031053 ! primary miRNA processing created_by: dph creation_date: 2011-04-18T03:50:56Z [Term] id: GO:2000637 name: positive regulation of gene silencing by miRNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA." [GOC:dph] synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr] synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol] synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol] is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:0060964 ! regulation of gene silencing by miRNA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035195 ! gene silencing by miRNA relationship: positively_regulates GO:0035195 ! gene silencing by miRNA created_by: dph creation_date: 2011-04-18T03:51:24Z [Term] id: GO:2000638 name: regulation of SREBP signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] synonym: "regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] synonym: "regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032933 ! SREBP signaling pathway relationship: regulates GO:0032933 ! SREBP signaling pathway created_by: vk creation_date: 2011-04-20T02:45:59Z [Term] id: GO:2000639 name: negative regulation of SREBP signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] synonym: "negative regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] synonym: "negative regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2000638 ! regulation of SREBP signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032933 ! SREBP signaling pathway relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway created_by: vk creation_date: 2011-04-20T02:46:02Z [Term] id: GO:2000640 name: positive regulation of SREBP signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] synonym: "positive regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] synonym: "positive regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:2000638 ! regulation of SREBP signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032933 ! SREBP signaling pathway relationship: positively_regulates GO:0032933 ! SREBP signaling pathway created_by: vk creation_date: 2011-04-20T02:46:05Z [Term] id: GO:2000641 name: regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903649 ! regulation of cytoplasmic transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045022 ! early endosome to late endosome transport relationship: regulates GO:0045022 ! early endosome to late endosome transport created_by: vk creation_date: 2011-04-21T11:20:02Z [Term] id: GO:2000642 name: negative regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903650 ! negative regulation of cytoplasmic transport is_a: GO:2000641 ! regulation of early endosome to late endosome transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045022 ! early endosome to late endosome transport relationship: negatively_regulates GO:0045022 ! early endosome to late endosome transport created_by: vk creation_date: 2011-04-21T11:20:06Z [Term] id: GO:2000643 name: positive regulation of early endosome to late endosome transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903651 ! positive regulation of cytoplasmic transport is_a: GO:2000641 ! regulation of early endosome to late endosome transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045022 ! early endosome to late endosome transport relationship: positively_regulates GO:0045022 ! early endosome to late endosome transport created_by: vk creation_date: 2011-04-21T11:20:09Z [Term] id: GO:2000644 name: regulation of receptor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "regulation of receptor breakdown" EXACT [GOC:obol] synonym: "regulation of receptor catabolism" EXACT [GOC:obol] synonym: "regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032801 ! receptor catabolic process relationship: regulates GO:0032801 ! receptor catabolic process created_by: vk creation_date: 2011-04-21T11:20:18Z [Term] id: GO:2000645 name: negative regulation of receptor catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "negative regulation of receptor breakdown" EXACT [GOC:obol] synonym: "negative regulation of receptor catabolism" EXACT [GOC:obol] synonym: "negative regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032801 ! receptor catabolic process relationship: negatively_regulates GO:0032801 ! receptor catabolic process created_by: vk creation_date: 2011-04-21T11:20:22Z [Term] id: GO:2000646 name: positive regulation of receptor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF] synonym: "positive regulation of receptor breakdown" EXACT [GOC:obol] synonym: "positive regulation of receptor catabolism" EXACT [GOC:obol] synonym: "positive regulation of receptor degradation" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032801 ! receptor catabolic process relationship: positively_regulates GO:0032801 ! receptor catabolic process created_by: vk creation_date: 2011-04-21T11:20:25Z [Term] id: GO:2000647 name: negative regulation of stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072089 ! stem cell proliferation relationship: negatively_regulates GO:0072089 ! stem cell proliferation created_by: dph creation_date: 2011-04-27T01:04:22Z [Term] id: GO:2000648 name: positive regulation of stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072089 ! stem cell proliferation relationship: positively_regulates GO:0072089 ! stem cell proliferation created_by: dph creation_date: 2011-04-27T01:04:25Z [Term] id: GO:2000649 name: regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1902305 ! regulation of sodium ion transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015081 ! sodium ion transmembrane transporter activity relationship: regulates GO:0015081 ! sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:42:53Z [Term] id: GO:2000650 name: negative regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity relationship: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:42:57Z [Term] id: GO:2000651 name: positive regulation of sodium ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity relationship: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity created_by: yaf creation_date: 2011-04-28T08:43:00Z [Term] id: GO:2000652 name: regulation of secondary cell wall biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol] synonym: "regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:obol] synonym: "regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:obol] synonym: "regulation of secondary cell wall anabolism" RELATED [GOC:obol] synonym: "regulation of secondary cell wall biosynthetic process" RELATED [GOC:obol] synonym: "regulation of secondary cell wall formation" RELATED [GOC:obol] synonym: "regulation of secondary cell wall synthesis" RELATED [GOC:obol] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903338 ! regulation of cell wall organization or biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009834 ! plant-type secondary cell wall biogenesis relationship: regulates GO:0009834 ! plant-type secondary cell wall biogenesis created_by: dhl creation_date: 2011-04-29T08:50:02Z [Term] id: GO:2000653 name: regulation of genetic imprinting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of genetic imprinting." [GOC:BHF] synonym: "regulation of DNA imprinting" EXACT [GOC:obol] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071514 ! genetic imprinting relationship: regulates GO:0071514 ! genetic imprinting created_by: vk creation_date: 2011-04-30T02:42:19Z [Term] id: GO:2000654 name: regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071394 ! cellular response to testosterone stimulus relationship: regulates GO:0071394 ! cellular response to testosterone stimulus created_by: vk creation_date: 2011-05-02T03:23:56Z [Term] id: GO:2000655 name: negative regulation of cellular response to testosterone stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus relationship: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus created_by: vk creation_date: 2011-05-02T03:23:59Z [Term] id: GO:2000656 name: regulation of apolipoprotein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034185 ! apolipoprotein binding relationship: regulates GO:0034185 ! apolipoprotein binding created_by: vk creation_date: 2011-05-02T05:33:41Z [Term] id: GO:2000657 name: negative regulation of apolipoprotein binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:2000656 ! regulation of apolipoprotein binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034185 ! apolipoprotein binding relationship: negatively_regulates GO:0034185 ! apolipoprotein binding created_by: vk creation_date: 2011-05-02T05:33:44Z [Term] id: GO:2000658 name: positive regulation of apolipoprotein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:2000656 ! regulation of apolipoprotein binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034185 ! apolipoprotein binding relationship: positively_regulates GO:0034185 ! apolipoprotein binding created_by: vk creation_date: 2011-05-02T05:33:46Z [Term] id: GO:2000659 name: regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070498 ! interleukin-1-mediated signaling pathway relationship: regulates GO:0070498 ! interleukin-1-mediated signaling pathway created_by: dph creation_date: 2011-05-03T07:13:31Z [Term] id: GO:2000660 name: negative regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "negative regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "negative regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway relationship: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway created_by: dph creation_date: 2011-05-03T07:13:37Z [Term] id: GO:2000661 name: positive regulation of interleukin-1-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] synonym: "positive regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] synonym: "positive regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway created_by: dph creation_date: 2011-05-03T07:13:40Z [Term] id: GO:2000662 name: regulation of interleukin-5 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0032674 ! regulation of interleukin-5 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072603 ! interleukin-5 secretion relationship: regulates GO:0072603 ! interleukin-5 secretion created_by: yaf creation_date: 2011-05-06T02:59:02Z [Term] id: GO:2000663 name: negative regulation of interleukin-5 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "negative regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0032714 ! negative regulation of interleukin-5 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000662 ! regulation of interleukin-5 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072603 ! interleukin-5 secretion relationship: negatively_regulates GO:0072603 ! interleukin-5 secretion created_by: yaf creation_date: 2011-05-06T02:59:05Z [Term] id: GO:2000664 name: positive regulation of interleukin-5 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] synonym: "positive regulation of IL-5 secretion" EXACT [GOC:obol] is_a: GO:0032754 ! positive regulation of interleukin-5 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000662 ! regulation of interleukin-5 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072603 ! interleukin-5 secretion relationship: positively_regulates GO:0072603 ! interleukin-5 secretion created_by: yaf creation_date: 2011-05-06T02:59:07Z [Term] id: GO:2000665 name: regulation of interleukin-13 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0032656 ! regulation of interleukin-13 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072611 ! interleukin-13 secretion relationship: regulates GO:0072611 ! interleukin-13 secretion created_by: yaf creation_date: 2011-05-06T03:24:19Z [Term] id: GO:2000666 name: negative regulation of interleukin-13 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "negative regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0032696 ! negative regulation of interleukin-13 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2000665 ! regulation of interleukin-13 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072611 ! interleukin-13 secretion relationship: negatively_regulates GO:0072611 ! interleukin-13 secretion created_by: yaf creation_date: 2011-05-06T03:24:22Z [Term] id: GO:2000667 name: positive regulation of interleukin-13 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] synonym: "positive regulation of IL-13 secretion" EXACT [GOC:obol] is_a: GO:0032736 ! positive regulation of interleukin-13 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2000665 ! regulation of interleukin-13 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072611 ! interleukin-13 secretion relationship: positively_regulates GO:0072611 ! interleukin-13 secretion created_by: yaf creation_date: 2011-05-06T03:24:25Z [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097048 ! dendritic cell apoptotic process relationship: regulates GO:0097048 ! dendritic cell apoptotic process created_by: pr creation_date: 2011-05-09T07:34:16Z [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097048 ! dendritic cell apoptotic process relationship: negatively_regulates GO:0097048 ! dendritic cell apoptotic process created_by: pr creation_date: 2011-05-09T07:34:21Z [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097048 ! dendritic cell apoptotic process relationship: positively_regulates GO:0097048 ! dendritic cell apoptotic process created_by: pr creation_date: 2011-05-09T07:34:26Z [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097049 ! motor neuron apoptotic process relationship: regulates GO:0097049 ! motor neuron apoptotic process created_by: pr creation_date: 2011-05-09T10:56:17Z [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "negative regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097049 ! motor neuron apoptotic process relationship: negatively_regulates GO:0097049 ! motor neuron apoptotic process created_by: pr creation_date: 2011-05-09T10:56:21Z [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "positive regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097049 ! motor neuron apoptotic process relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process created_by: pr creation_date: 2011-05-09T10:56:24Z [Term] id: GO:2000674 name: regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097050 ! type B pancreatic cell apoptotic process relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process created_by: pr creation_date: 2011-05-09T11:51:09Z [Term] id: GO:2000675 name: negative regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process created_by: pr creation_date: 2011-05-09T11:51:12Z [Term] id: GO:2000676 name: positive regulation of type B pancreatic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW [] is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process created_by: pr creation_date: 2011-05-09T11:51:15Z [Term] id: GO:2000677 name: regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044212 ! transcription regulatory region DNA binding relationship: regulates GO:0044212 ! transcription regulatory region DNA binding created_by: yaf creation_date: 2011-05-09T03:28:11Z [Term] id: GO:2000678 name: negative regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0043392 ! negative regulation of DNA binding is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044212 ! transcription regulatory region DNA binding relationship: negatively_regulates GO:0044212 ! transcription regulatory region DNA binding created_by: yaf creation_date: 2011-05-09T03:28:14Z [Term] id: GO:2000679 name: positive regulation of transcription regulatory region DNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] is_a: GO:0043388 ! positive regulation of DNA binding is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044212 ! transcription regulatory region DNA binding relationship: positively_regulates GO:0044212 ! transcription regulatory region DNA binding created_by: yaf creation_date: 2011-05-09T03:28:17Z [Term] id: GO:2000680 name: obsolete regulation of rubidium ion transport namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transport." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "regulation of Rb+ transport" EXACT [GOC:obol] synonym: "regulation of rubidium cation transport" EXACT [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-10T10:54:31Z [Term] id: GO:2000681 name: obsolete negative regulation of rubidium ion transport namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "negative regulation of Rb+ transport" EXACT [GOC:obol] synonym: "negative regulation of rubidium cation transport" EXACT [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-10T10:54:34Z [Term] id: GO:2000682 name: obsolete positive regulation of rubidium ion transport namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transport." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "positive regulation of Rb+ transport" EXACT [GOC:obol] synonym: "positive regulation of rubidium cation transport" EXACT [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-10T10:54:37Z [Term] id: GO:2000683 name: regulation of cellular response to X-ray namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071481 ! cellular response to X-ray relationship: regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:41Z [Term] id: GO:2000684 name: negative regulation of cellular response to X-ray namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071481 ! cellular response to X-ray relationship: negatively_regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:45Z [Term] id: GO:2000685 name: positive regulation of cellular response to X-ray namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol] synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000683 ! regulation of cellular response to X-ray intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071481 ! cellular response to X-ray relationship: positively_regulates GO:0071481 ! cellular response to X-ray created_by: yaf creation_date: 2011-05-10T01:40:49Z [Term] id: GO:2000686 name: obsolete regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-11T09:27:29Z [Term] id: GO:2000687 name: obsolete negative regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "negative regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "negative regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "negative regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-11T09:27:32Z [Term] id: GO:2000688 name: obsolete positive regulation of rubidium ion transmembrane transporter activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] comment: This term has been obsoleted because it represents an assay, and not a physiological process. synonym: "positive regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] synonym: "positive regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] synonym: "positive regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-05-11T09:27:33Z [Term] id: GO:2000689 name: actomyosin contractile ring assembly actin filament organization namespace: biological_process def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "actin filament organization involved in cytokinetic actomyosin contractile ring assembly" EXACT [] synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0007015 ! actin filament organization is_a: GO:0022402 ! cell cycle process intersection_of: GO:0007015 ! actin filament organization intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly relationship: part_of GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2011-05-17T11:48:12Z [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:01Z [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:06Z [Term] id: GO:2000692 name: negative regulation of seed maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000034 ! regulation of seed maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010431 ! seed maturation relationship: negatively_regulates GO:0010431 ! seed maturation created_by: dhl creation_date: 2011-05-13T06:41:43Z [Term] id: GO:2000693 name: positive regulation of seed maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of seed maturation." [GOC:obol] is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000034 ! regulation of seed maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010431 ! seed maturation relationship: positively_regulates GO:0010431 ! seed maturation created_by: dhl creation_date: 2011-05-13T06:41:46Z [Term] id: GO:2000694 name: regulation of phragmoplast microtubule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol] synonym: "regulation of phragmoplast microtubule cytoskeleton organization" EXACT [GOC:obol] synonym: "regulation of phragmoplast microtubule organisation" EXACT [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0080175 ! phragmoplast microtubule organization relationship: regulates GO:0080175 ! phragmoplast microtubule organization created_by: tanyaberardini creation_date: 2011-05-13T09:32:27Z [Term] id: GO:2000696 name: regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0090183 ! regulation of kidney development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development created_by: rfoulger creation_date: 2011-05-16T04:23:52Z [Term] id: GO:2000697 name: negative regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0090185 ! negative regulation of kidney development is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development created_by: rfoulger creation_date: 2011-05-16T04:23:55Z [Term] id: GO:2000698 name: positive regulation of epithelial cell differentiation involved in kidney development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0090184 ! positive regulation of kidney development is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development created_by: rfoulger creation_date: 2011-05-16T04:23:57Z [Term] id: GO:2000699 name: fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:yaf] synonym: "FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway intersection_of: part_of GO:0060676 ! ureteric bud formation relationship: part_of GO:0060676 ! ureteric bud formation created_by: rfoulger creation_date: 2011-05-16T04:52:14Z [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: yaf creation_date: 2011-05-25T09:08:09Z [Term] id: GO:2000701 name: glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway intersection_of: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway intersection_of: part_of GO:0060676 ! ureteric bud formation relationship: part_of GO:0060676 ! ureteric bud formation created_by: yaf creation_date: 2011-05-25T09:34:07Z [Term] id: GO:2000702 name: regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0072106 ! regulation of ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation relationship: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-05-25T09:48:15Z [Term] id: GO:2000703 name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "negative regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905277 ! negative regulation of epithelial tube formation is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation relationship: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-05-25T09:48:22Z [Term] id: GO:2000704 name: positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "positive regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway is_a: GO:0072107 ! positive regulation of ureteric bud formation is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation relationship: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-05-25T09:48:27Z [Term] id: GO:2000705 name: regulation of dense core granule biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061110 ! dense core granule biogenesis relationship: regulates GO:0061110 ! dense core granule biogenesis created_by: yaf creation_date: 2011-05-26T10:29:21Z [Term] id: GO:2000706 name: negative regulation of dense core granule biogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000705 ! regulation of dense core granule biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061110 ! dense core granule biogenesis relationship: negatively_regulates GO:0061110 ! dense core granule biogenesis created_by: yaf creation_date: 2011-05-26T10:29:27Z [Term] id: GO:2000707 name: positive regulation of dense core granule biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:2000705 ! regulation of dense core granule biogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061110 ! dense core granule biogenesis relationship: positively_regulates GO:0061110 ! dense core granule biogenesis created_by: yaf creation_date: 2011-05-26T10:29:30Z [Term] id: GO:2000708 name: myosin filament organization involved in cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "myosin filament assembly or disassembly of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly" EXACT [GOC:mah] synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0022402 ! cell cycle process is_a: GO:0031033 ! myosin filament organization intersection_of: GO:0031033 ! myosin filament organization intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly relationship: part_of GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2011-06-01T12:33:56Z [Term] id: GO:2000709 name: regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric relationship: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-01T12:41:11Z [Term] id: GO:2000710 name: negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "negative regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric relationship: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-01T12:41:16Z [Term] id: GO:2000711 name: positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "positive regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric relationship: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-01T12:41:18Z [Term] id: GO:2000712 name: regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms relationship: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-01T12:45:35Z [Term] id: GO:2000713 name: negative regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms relationship: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-01T12:45:39Z [Term] id: GO:2000714 name: positive regulation of maintenance of meiotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms relationship: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-01T12:45:42Z [Term] id: GO:2000715 name: regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms relationship: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-03T10:38:29Z [Term] id: GO:2000716 name: negative regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms relationship: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-03T10:38:32Z [Term] id: GO:2000717 name: positive regulation of maintenance of mitotic sister chromatid cohesion, arms namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms relationship: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms created_by: midori creation_date: 2011-06-03T10:38:35Z [Term] id: GO:2000718 name: regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric relationship: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-03T10:41:11Z [Term] id: GO:2000719 name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric relationship: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-03T10:41:14Z [Term] id: GO:2000720 name: positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] synonym: "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric relationship: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-06-03T10:41:16Z [Term] id: GO:2000721 name: positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] synonym: "activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0051145 ! smooth muscle cell differentiation created_by: vk creation_date: 2011-06-08T08:34:55Z [Term] id: GO:2000722 name: regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation relationship: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: vk creation_date: 2011-06-08T08:47:58Z [Term] id: GO:2000723 name: negative regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation relationship: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: vk creation_date: 2011-06-08T08:48:01Z [Term] id: GO:2000724 name: positive regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation relationship: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: vk creation_date: 2011-06-08T08:48:04Z [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:0055024 ! regulation of cardiac muscle tissue development is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0055007 ! cardiac muscle cell differentiation relationship: regulates GO:0055007 ! cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:06Z [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055026 ! negative regulation of cardiac muscle tissue development is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation relationship: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:11Z [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055025 ! positive regulation of cardiac muscle tissue development is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0055007 ! cardiac muscle cell differentiation relationship: positively_regulates GO:0055007 ! cardiac muscle cell differentiation created_by: vk creation_date: 2011-06-08T10:51:15Z [Term] id: GO:2000728 name: regulation of mRNA export from nucleus in response to heat stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress." [PMID:15210706] synonym: "regulation of mRNA export from cell nucleus during heat stress" EXACT [GOC:obol] synonym: "regulation of mRNA export from nucleus during heat stress" RELATED [GOC:obol] is_a: GO:0010793 ! regulation of mRNA export from nucleus is_a: GO:1900034 ! regulation of cellular response to heat intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress relationship: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress created_by: pr creation_date: 2011-06-08T12:17:45Z [Term] id: GO:2000729 name: positive regulation of mesenchymal cell proliferation involved in ureter development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol] synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol] synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development relationship: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development created_by: yaf creation_date: 2011-06-10T02:27:19Z [Term] id: GO:2000730 name: regulation of termination of RNA polymerase I transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] synonym: "regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] synonym: "regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] synonym: "regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:0031554 ! regulation of DNA-templated transcription, termination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006363 ! termination of RNA polymerase I transcription relationship: regulates GO:0006363 ! termination of RNA polymerase I transcription created_by: dph creation_date: 2011-06-10T08:43:39Z [Term] id: GO:2000731 name: negative regulation of termination of RNA polymerase I transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] synonym: "negative regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] synonym: "negative regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] synonym: "negative regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription relationship: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription created_by: dph creation_date: 2011-06-10T08:43:44Z [Term] id: GO:2000732 name: positive regulation of termination of RNA polymerase I transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] synonym: "positive regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] synonym: "positive regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] synonym: "positive regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription relationship: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription created_by: dph creation_date: 2011-06-10T08:43:48Z [Term] id: GO:2000733 name: regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0072106 ! regulation of ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation relationship: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-06-13T11:14:40Z [Term] id: GO:2000734 name: negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "negative regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905277 ! negative regulation of epithelial tube formation is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation relationship: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-06-13T11:14:44Z [Term] id: GO:2000735 name: positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] synonym: "positive regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0072107 ! positive regulation of ureteric bud formation is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation relationship: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation created_by: yaf creation_date: 2011-06-13T11:14:46Z [Term] id: GO:2000736 name: regulation of stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0048863 ! stem cell differentiation relationship: regulates GO:0048863 ! stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:16Z [Term] id: GO:2000737 name: negative regulation of stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0048863 ! stem cell differentiation relationship: negatively_regulates GO:0048863 ! stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:20Z [Term] id: GO:2000738 name: positive regulation of stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0048863 ! stem cell differentiation relationship: positively_regulates GO:0048863 ! stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:23Z [Term] id: GO:2000739 name: regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072497 ! mesenchymal stem cell differentiation relationship: regulates GO:0072497 ! mesenchymal stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:31:27Z [Term] id: GO:2000740 name: negative regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000737 ! negative regulation of stem cell differentiation is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation relationship: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:31:31Z [Term] id: GO:2000741 name: positive regulation of mesenchymal stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] is_a: GO:2000738 ! positive regulation of stem cell differentiation is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation relationship: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:31:34Z [Term] id: GO:2000742 name: regulation of anterior head development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterior head development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097065 ! anterior head development relationship: regulates GO:0097065 ! anterior head development created_by: yaf creation_date: 2011-06-14T09:44:09Z [Term] id: GO:2000743 name: negative regulation of anterior head development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development." [GOC:obol] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000742 ! regulation of anterior head development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097065 ! anterior head development relationship: negatively_regulates GO:0097065 ! anterior head development created_by: yaf creation_date: 2011-06-14T09:44:14Z [Term] id: GO:2000744 name: positive regulation of anterior head development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterior head development." [GOC:obol] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000742 ! regulation of anterior head development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097065 ! anterior head development relationship: positively_regulates GO:0097065 ! anterior head development created_by: yaf creation_date: 2011-06-14T09:44:17Z [Term] id: GO:2000745 name: obsolete positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation namespace: biological_process def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase III promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] comment: This term was made obsolete because it was added in error. synonym: "activation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "activation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "positive regulation of transcription from Pol III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation" EXACT [] synonym: "positive regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "stimulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "stimulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "up regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "up regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "up-regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "up-regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "upregulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "upregulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] is_obsolete: true created_by: rfoulger creation_date: 2011-06-15T10:03:19Z [Term] id: GO:2000746 name: regulation of defecation rhythm namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defecation rhythm." [GOC:kmv] synonym: "regulation of defecation behavior" RELATED [GOC:obol] synonym: "regulation of defecation cycle" EXACT [GOC:obol] synonym: "regulation of defecation motor program" EXACT [GOC:obol] synonym: "regulation of DMP" EXACT [GOC:obol] is_a: GO:2000292 ! regulation of defecation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035882 ! defecation rhythm relationship: regulates GO:0035882 ! defecation rhythm created_by: rfoulger creation_date: 2011-06-15T03:23:07Z [Term] id: GO:2000747 name: negative regulation of defecation rhythm namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm." [GOC:kmv] synonym: "negative regulation of defecation behavior" RELATED [GOC:obol] synonym: "negative regulation of defecation cycle" EXACT [GOC:obol] synonym: "negative regulation of defecation motor program" EXACT [GOC:obol] synonym: "negative regulation of DMP" EXACT [GOC:obol] is_a: GO:2000293 ! negative regulation of defecation is_a: GO:2000746 ! regulation of defecation rhythm intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035882 ! defecation rhythm relationship: negatively_regulates GO:0035882 ! defecation rhythm created_by: rfoulger creation_date: 2011-06-15T03:23:10Z [Term] id: GO:2000748 name: positive regulation of defecation rhythm namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defecation rhythm." [GOC:kmv] synonym: "positive regulation of defecation behavior" RELATED [GOC:obol] synonym: "positive regulation of defecation cycle" EXACT [GOC:obol] synonym: "positive regulation of defecation motor program" EXACT [GOC:obol] synonym: "positive regulation of DMP" EXACT [GOC:obol] is_a: GO:2000294 ! positive regulation of defecation is_a: GO:2000746 ! regulation of defecation rhythm intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035882 ! defecation rhythm relationship: positively_regulates GO:0035882 ! defecation rhythm created_by: rfoulger creation_date: 2011-06-15T03:23:13Z [Term] id: GO:2000749 name: positive regulation of chromatin silencing at rDNA namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at rDNA." [PMID:10899127] synonym: "positive regulation of chromatin silencing at ribosomal DNA" EXACT [GOC:obol] synonym: "positive regulation of heterochromatic silencing at rDNA" EXACT [GOC:obol] synonym: "positive regulation of rDNA chromatin silencing" EXACT [GOC:obol] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0061187 ! regulation of chromatin silencing at rDNA intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000183 ! chromatin silencing at rDNA relationship: positively_regulates GO:0000183 ! chromatin silencing at rDNA created_by: pr creation_date: 2011-06-16T09:43:55Z [Term] id: GO:2000750 name: negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:mah] is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape relationship: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape created_by: midori creation_date: 2011-06-16T11:51:49Z [Term] id: GO:2000751 name: histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore namespace: biological_process def: "Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol] synonym: "histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol] synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol] synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore" EXACT [GOC:obol] synonym: "histone H3-T3 phosphorylation of CPC complex localization to kinetochore" EXACT [GOC:obol] synonym: "histone H3-T3 phosphorylation of CPC localization to kinetochore" EXACT [GOC:obol] is_a: GO:0072355 ! histone H3-T3 phosphorylation intersection_of: GO:0072355 ! histone H3-T3 phosphorylation intersection_of: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore created_by: vw creation_date: 2011-06-16T12:56:29Z [Term] id: GO:2000752 name: regulation of glucosylceramide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF] synonym: "regulation of glucosylceramide breakdown" EXACT [GOC:obol] synonym: "regulation of glucosylceramide catabolism" EXACT [GOC:obol] synonym: "regulation of glucosylceramide degradation" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:1905038 ! regulation of membrane lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006680 ! glucosylceramide catabolic process relationship: regulates GO:0006680 ! glucosylceramide catabolic process created_by: rl creation_date: 2011-06-16T03:12:04Z [Term] id: GO:2000753 name: positive regulation of glucosylceramide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF] synonym: "positive regulation of glucosylceramide breakdown" EXACT [GOC:obol] synonym: "positive regulation of glucosylceramide catabolism" EXACT [GOC:obol] synonym: "positive regulation of glucosylceramide degradation" EXACT [GOC:obol] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:2000752 ! regulation of glucosylceramide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006680 ! glucosylceramide catabolic process relationship: positively_regulates GO:0006680 ! glucosylceramide catabolic process created_by: rl creation_date: 2011-06-16T03:12:09Z [Term] id: GO:2000754 name: regulation of sphingomyelin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF] synonym: "regulation of sphingomyelin breakdown" EXACT [GOC:obol] synonym: "regulation of sphingomyelin catabolism" EXACT [GOC:obol] synonym: "regulation of sphingomyelin degradation" EXACT [GOC:obol] is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process is_a: GO:1905038 ! regulation of membrane lipid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006685 ! sphingomyelin catabolic process relationship: regulates GO:0006685 ! sphingomyelin catabolic process created_by: rl creation_date: 2011-06-16T03:17:30Z [Term] id: GO:2000755 name: positive regulation of sphingomyelin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF] synonym: "positive regulation of sphingomyelin breakdown" EXACT [GOC:obol] synonym: "positive regulation of sphingomyelin catabolism" EXACT [GOC:obol] synonym: "positive regulation of sphingomyelin degradation" EXACT [GOC:obol] is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0060697 ! positive regulation of phospholipid catabolic process is_a: GO:2000754 ! regulation of sphingomyelin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006685 ! sphingomyelin catabolic process relationship: positively_regulates GO:0006685 ! sphingomyelin catabolic process created_by: rl creation_date: 2011-06-16T03:17:35Z [Term] id: GO:2000756 name: regulation of peptidyl-lysine acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1901983 ! regulation of protein acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018394 ! peptidyl-lysine acetylation relationship: regulates GO:0018394 ! peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-16T09:51:26Z [Term] id: GO:2000757 name: negative regulation of peptidyl-lysine acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1901984 ! negative regulation of protein acetylation is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation relationship: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-16T09:51:31Z [Term] id: GO:2000758 name: positive regulation of peptidyl-lysine acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1901985 ! positive regulation of protein acetylation is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018394 ! peptidyl-lysine acetylation relationship: positively_regulates GO:0018394 ! peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-16T09:51:35Z [Term] id: GO:2000759 name: regulation of N-terminal peptidyl-lysine acetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1903317 ! regulation of protein maturation is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation relationship: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-17T12:58:16Z [Term] id: GO:2000760 name: negative regulation of N-terminal peptidyl-lysine acetylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1903318 ! negative regulation of protein maturation is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation relationship: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-17T12:58:20Z [Term] id: GO:2000761 name: positive regulation of N-terminal peptidyl-lysine acetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] is_a: GO:1903319 ! positive regulation of protein maturation is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation relationship: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation created_by: yaf creation_date: 2011-06-17T12:58:24Z [Term] id: GO:2000762 name: regulation of phenylpropanoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process." [GOC:obol] synonym: "regulation of phenylpropanoid metabolism" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009698 ! phenylpropanoid metabolic process relationship: regulates GO:0009698 ! phenylpropanoid metabolic process created_by: tanyaberardini creation_date: 2011-06-17T06:13:43Z [Term] id: GO:2000763 name: positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process." [GOC:BHF] synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine formation" EXACT [GOC:obol] synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis" EXACT [GOC:obol] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: GO:0045944 ! positive regulation of transcription by RNA polymerase II intersection_of: part_of GO:0042421 ! norepinephrine biosynthetic process relationship: part_of GO:0042421 ! norepinephrine biosynthetic process created_by: vk creation_date: 2011-06-18T04:14:58Z [Term] id: GO:2000764 name: positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis." [GOC:BHF] synonym: "positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:obol] is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2000826 ! regulation of heart morphogenesis is_a: GO:2001262 ! positive regulation of semaphorin-plexin signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis relationship: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis created_by: vk creation_date: 2011-06-18T04:26:00Z [Term] id: GO:2000765 name: regulation of cytoplasmic translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002181 ! cytoplasmic translation relationship: regulates GO:0002181 ! cytoplasmic translation created_by: vw creation_date: 2011-06-20T10:39:19Z [Term] id: GO:2000766 name: negative regulation of cytoplasmic translation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0017148 ! negative regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002181 ! cytoplasmic translation relationship: negatively_regulates GO:0002181 ! cytoplasmic translation created_by: vw creation_date: 2011-06-20T10:39:23Z [Term] id: GO:2000767 name: positive regulation of cytoplasmic translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0045727 ! positive regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002181 ! cytoplasmic translation relationship: positively_regulates GO:0002181 ! cytoplasmic translation created_by: vw creation_date: 2011-06-20T10:39:26Z [Term] id: GO:2000768 name: positive regulation of nephron tubule epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol] is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation created_by: yaf creation_date: 2011-06-22T11:55:06Z [Term] id: GO:2000769 name: regulation of establishment or maintenance of cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape relationship: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-22T01:56:49Z [Term] id: GO:2000770 name: negative regulation of establishment or maintenance of cell polarity regulating cell shape namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape relationship: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-22T01:56:53Z [Term] id: GO:2000771 name: positive regulation of establishment or maintenance of cell polarity regulating cell shape namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape relationship: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-22T01:56:55Z [Term] id: GO:2000772 name: regulation of cellular senescence namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular senescence." [GOC:BHF] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:0090342 ! regulation of cell aging intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0090398 ! cellular senescence relationship: regulates GO:0090398 ! cellular senescence created_by: rfoulger creation_date: 2011-06-22T01:57:04Z [Term] id: GO:2000773 name: negative regulation of cellular senescence namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence." [GOC:BHF] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0090344 ! negative regulation of cell aging is_a: GO:2000772 ! regulation of cellular senescence intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0090398 ! cellular senescence relationship: negatively_regulates GO:0090398 ! cellular senescence created_by: rfoulger creation_date: 2011-06-22T01:57:08Z [Term] id: GO:2000774 name: positive regulation of cellular senescence namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular senescence." [GOC:BHF] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0090343 ! positive regulation of cell aging is_a: GO:2000772 ! regulation of cellular senescence intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0090398 ! cellular senescence relationship: positively_regulates GO:0090398 ! cellular senescence created_by: rfoulger creation_date: 2011-06-22T01:57:12Z [Term] id: GO:2000775 name: histone H3-S10 phosphorylation involved in chromosome condensation namespace: biological_process def: "Any histone H3-S10 phosphorylation that is involved in chromosome condensation." [GOC:obol] synonym: "histone H3 phosphorylation at S10 of chromosome condensation" EXACT [GOC:obol] synonym: "histone H3-S10 phosphorylation of chromosome condensation" EXACT [GOC:obol] synonym: "histone H3S10 phosphorylation of chromosome condensation" EXACT [GOC:obol] is_a: GO:0043987 ! histone H3-S10 phosphorylation intersection_of: GO:0043987 ! histone H3-S10 phosphorylation intersection_of: part_of GO:0030261 ! chromosome condensation relationship: part_of GO:0030261 ! chromosome condensation created_by: midori creation_date: 2011-06-22T03:58:00Z [Term] id: GO:2000776 name: histone H4 acetylation involved in response to DNA damage stimulus namespace: biological_process def: "Any histone H4 acetylation that is involved in a response to DNA damage stimulus." [GOC:mah] synonym: "histone H4 acetylation of cellular DNA damage response" EXACT [GOC:obol] synonym: "histone H4 acetylation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "histone H4 acetylation of DNA damage response" EXACT [GOC:obol] synonym: "histone H4 acetylation of response to DNA damage stimulus" EXACT [GOC:obol] synonym: "histone H4 acetylation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0043967 ! histone H4 acetylation intersection_of: GO:0043967 ! histone H4 acetylation intersection_of: part_of GO:0006974 ! cellular response to DNA damage stimulus relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus created_by: midori creation_date: 2011-06-22T04:00:54Z [Term] id: GO:2000777 name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia namespace: biological_process def: "Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia." [GOC:mah] synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress" EXACT [GOC:obol] synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension" EXACT [GOC:obol] is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process intersection_of: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process intersection_of: part_of GO:0071456 ! cellular response to hypoxia relationship: part_of GO:0071456 ! cellular response to hypoxia created_by: midori creation_date: 2011-06-22T04:07:20Z [Term] id: GO:2000778 name: positive regulation of interleukin-6 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion." [GOC:BHF] synonym: "positive regulation of IL-6 secretion" EXACT [GOC:obol] is_a: GO:0032755 ! positive regulation of interleukin-6 production is_a: GO:0050715 ! positive regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072604 ! interleukin-6 secretion relationship: positively_regulates GO:0072604 ! interleukin-6 secretion created_by: vk creation_date: 2011-06-22T08:27:45Z [Term] id: GO:2000779 name: regulation of double-strand break repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] is_a: GO:0006282 ! regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006302 ! double-strand break repair relationship: regulates GO:0006302 ! double-strand break repair created_by: rfoulger creation_date: 2011-06-23T09:28:02Z [Term] id: GO:2000780 name: negative regulation of double-strand break repair namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF] is_a: GO:0045738 ! negative regulation of DNA repair is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006302 ! double-strand break repair relationship: negatively_regulates GO:0006302 ! double-strand break repair created_by: rfoulger creation_date: 2011-06-23T09:28:08Z [Term] id: GO:2000781 name: positive regulation of double-strand break repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] is_a: GO:0045739 ! positive regulation of DNA repair is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006302 ! double-strand break repair relationship: positively_regulates GO:0006302 ! double-strand break repair created_by: rfoulger creation_date: 2011-06-23T09:28:13Z [Term] id: GO:2000782 name: regulation of establishment of cell polarity regulating cell shape namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] is_a: GO:2000114 ! regulation of establishment of cell polarity is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071964 ! establishment of cell polarity regulating cell shape relationship: regulates GO:0071964 ! establishment of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-23T12:17:38Z [Term] id: GO:2000783 name: negative regulation of establishment of cell polarity regulating cell shape namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape relationship: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-23T12:17:44Z [Term] id: GO:2000784 name: positive regulation of establishment of cell polarity regulating cell shape namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape relationship: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape created_by: midori creation_date: 2011-06-23T12:17:48Z [Term] id: GO:2000785 name: regulation of autophagosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF] synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol] synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol] synonym: "regulation of autophagosome formation" EXACT [GOC:obol] synonym: "regulation of PAS formation" RELATED [GOC:obol] is_a: GO:0016241 ! regulation of macroautophagy is_a: GO:0044088 ! regulation of vacuole organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0000045 ! autophagosome assembly relationship: regulates GO:0000045 ! autophagosome assembly created_by: rl creation_date: 2011-06-24T11:19:08Z [Term] id: GO:2000786 name: positive regulation of autophagosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF] synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol] synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol] synonym: "positive regulation of PAS formation" RELATED [GOC:obol] is_a: GO:0016239 ! positive regulation of macroautophagy is_a: GO:0044090 ! positive regulation of vacuole organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:2000785 ! regulation of autophagosome assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000045 ! autophagosome assembly relationship: positively_regulates GO:0000045 ! autophagosome assembly created_by: rl creation_date: 2011-06-24T11:19:12Z [Term] id: GO:2000787 name: regulation of venous endothelial cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060845 ! venous endothelial cell fate commitment relationship: regulates GO:0060845 ! venous endothelial cell fate commitment created_by: rfoulger creation_date: 2011-06-24T01:26:12Z [Term] id: GO:2000788 name: negative regulation of venous endothelial cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0110059 ! negative regulation of blood vessel endothelial cell differentiation is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment relationship: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment created_by: rfoulger creation_date: 2011-06-24T01:26:16Z [Term] id: GO:2000789 name: positive regulation of venous endothelial cell fate commitment namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0110058 ! positive regulation of blood vessel endothelial cell differentiation is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060845 ! venous endothelial cell fate commitment relationship: positively_regulates GO:0060845 ! venous endothelial cell fate commitment created_by: rfoulger creation_date: 2011-06-24T01:26:19Z [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development relationship: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development created_by: pr creation_date: 2011-06-24T01:53:50Z [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development relationship: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development created_by: pr creation_date: 2011-06-24T01:53:53Z [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development relationship: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development created_by: pr creation_date: 2011-06-24T01:53:56Z [Term] id: GO:2000793 name: cell proliferation involved in heart valve development namespace: biological_process def: "Any cell proliferation that is involved in heart valve development." [GOC:BHF] synonym: "cell proliferation of cardiac valve development" EXACT [GOC:obol] synonym: "cell proliferation of heart valve development" EXACT [GOC:obol] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0003170 ! heart valve development relationship: part_of GO:0003170 ! heart valve development created_by: rfoulger creation_date: 2011-06-24T03:12:15Z [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis relationship: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis created_by: pr creation_date: 2011-06-25T07:22:38Z [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis relationship: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis created_by: pr creation_date: 2011-06-25T07:22:42Z [Term] id: GO:2000796 name: Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment namespace: biological_process def: "Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment." [PMID:11585794] synonym: "N signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] synonym: "Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] synonym: "Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] synonym: "Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] synonym: "Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] synonym: "Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] is_a: GO:0007219 ! Notch signaling pathway intersection_of: GO:0007219 ! Notch signaling pathway intersection_of: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment relationship: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment created_by: rfoulger creation_date: 2011-06-27T09:07:42Z [Term] id: GO:2000797 name: regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097086 ! amniotic stem cell differentiation relationship: regulates GO:0097086 ! amniotic stem cell differentiation created_by: yaf creation_date: 2011-06-29T02:18:59Z [Term] id: GO:2000798 name: negative regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000740 ! negative regulation of mesenchymal stem cell differentiation is_a: GO:2000797 ! regulation of amniotic stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097086 ! amniotic stem cell differentiation relationship: negatively_regulates GO:0097086 ! amniotic stem cell differentiation created_by: yaf creation_date: 2011-06-29T02:19:03Z [Term] id: GO:2000799 name: positive regulation of amniotic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] is_a: GO:2000741 ! positive regulation of mesenchymal stem cell differentiation is_a: GO:2000797 ! regulation of amniotic stem cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097086 ! amniotic stem cell differentiation relationship: positively_regulates GO:0097086 ! amniotic stem cell differentiation created_by: yaf creation_date: 2011-06-29T02:19:06Z [Term] id: GO:2000800 name: regulation of endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] synonym: "regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation relationship: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation created_by: rfoulger creation_date: 2011-07-01T12:31:18Z [Term] id: GO:2000801 name: negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] synonym: "negative regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] is_a: GO:0140050 ! negative regulation of endocardial cushion to mesenchymal transition is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation relationship: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation created_by: rfoulger creation_date: 2011-07-01T12:31:22Z [Term] id: GO:2000802 name: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] synonym: "positive regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] is_a: GO:0140051 ! positive regulation of endocardial cushion to mesenchymal transition is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation relationship: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation created_by: rfoulger creation_date: 2011-07-01T12:31:25Z [Term] id: GO:2000803 name: endosomal signal transduction namespace: biological_process def: "The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction." [GOC:bf, GOC:signaling, PMID:15084302, PMID:17662591] synonym: "endosome-based signaling" EXACT [PMID:17662591] synonym: "signaling cascade in endosome" RELATED [GOC:obol] synonym: "signaling from endosome" EXACT [PMID:17662591] synonym: "signaling pathway in endosome" RELATED [GOC:obol] synonym: "signalling cascade in endosome" RELATED [GOC:obol] synonym: "signalling pathway in endosome" RELATED [GOC:obol] is_a: GO:0035556 ! intracellular signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: occurs_in GO:0005768 ! endosome relationship: occurs_in GO:0005768 ! endosome created_by: rfoulger creation_date: 2011-07-01T03:45:12Z [Term] id: GO:2000804 name: regulation of termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] synonym: "regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] synonym: "regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] synonym: "regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled relationship: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled created_by: pr creation_date: 2011-07-04T08:41:27Z [Term] id: GO:2000805 name: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] synonym: "negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] synonym: "negative regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] synonym: "negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] is_a: GO:0120191 ! negative regulation of termination of RNA polymerase II transcription is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled relationship: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled created_by: pr creation_date: 2011-07-04T08:41:34Z [Term] id: GO:2000806 name: positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] synonym: "positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] synonym: "positive regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] synonym: "positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] is_a: GO:1904595 ! positive regulation of termination of RNA polymerase II transcription is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled relationship: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled created_by: pr creation_date: 2011-07-04T08:41:39Z [Term] id: GO:2000807 name: regulation of synaptic vesicle clustering namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0098693 ! regulation of synaptic vesicle cycle intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097091 ! synaptic vesicle clustering relationship: regulates GO:0097091 ! synaptic vesicle clustering created_by: pr creation_date: 2011-07-06T09:50:30Z [Term] id: GO:2000808 name: negative regulation of synaptic vesicle clustering namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] is_a: GO:0051051 ! negative regulation of transport is_a: GO:2000807 ! regulation of synaptic vesicle clustering intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097091 ! synaptic vesicle clustering relationship: negatively_regulates GO:0097091 ! synaptic vesicle clustering created_by: pr creation_date: 2011-07-06T09:50:34Z [Term] id: GO:2000809 name: positive regulation of synaptic vesicle clustering namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] is_a: GO:0051050 ! positive regulation of transport is_a: GO:2000807 ! regulation of synaptic vesicle clustering intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097091 ! synaptic vesicle clustering relationship: positively_regulates GO:0097091 ! synaptic vesicle clustering created_by: pr creation_date: 2011-07-06T09:50:37Z [Term] id: GO:2000810 name: regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF] synonym: "regulation of tight junction formation" EXACT [GOC:obol] is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070830 ! bicellular tight junction assembly relationship: regulates GO:0070830 ! bicellular tight junction assembly created_by: vk creation_date: 2011-07-06T01:08:28Z [Term] id: GO:2000811 name: negative regulation of anoikis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis." [GOC:obol] synonym: "negative regulation of detachment induced cell death" EXACT [GOC:obol] synonym: "negative regulation of suspension induced apoptosis" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000209 ! regulation of anoikis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043276 ! anoikis relationship: negatively_regulates GO:0043276 ! anoikis created_by: pr creation_date: 2011-07-07T09:42:20Z [Term] id: GO:2000812 name: regulation of barbed-end actin filament capping namespace: biological_process def: "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] synonym: "regulation of barbed-end actin capping activity" EXACT [GOC:obol] synonym: "regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] synonym: "regulation of plus-end actin filament capping activity" EXACT [GOC:obol] synonym: "regulation of plus-end F-actin capping activity" EXACT [GOC:obol] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0030834 ! regulation of actin filament depolymerization intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051016 ! barbed-end actin filament capping relationship: regulates GO:0051016 ! barbed-end actin filament capping created_by: rl creation_date: 2011-07-07T04:08:13Z [Term] id: GO:2000813 name: negative regulation of barbed-end actin filament capping namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] synonym: "negative regulation of barbed-end actin capping activity" EXACT [GOC:obol] synonym: "negative regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] synonym: "negative regulation of plus-end actin filament capping activity" EXACT [GOC:obol] synonym: "negative regulation of plus-end F-actin capping activity" EXACT [GOC:obol] is_a: GO:0030836 ! positive regulation of actin filament depolymerization is_a: GO:0030838 ! positive regulation of actin filament polymerization is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000812 ! regulation of barbed-end actin filament capping intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051016 ! barbed-end actin filament capping relationship: negatively_regulates GO:0051016 ! barbed-end actin filament capping created_by: rl creation_date: 2011-07-07T04:08:18Z [Term] id: GO:2000814 name: positive regulation of barbed-end actin filament capping namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] synonym: "positive regulation of barbed-end actin capping activity" EXACT [GOC:obol] synonym: "positive regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] synonym: "positive regulation of plus-end actin filament capping activity" EXACT [GOC:obol] synonym: "positive regulation of plus-end F-actin capping activity" EXACT [GOC:obol] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000812 ! regulation of barbed-end actin filament capping intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051016 ! barbed-end actin filament capping relationship: positively_regulates GO:0051016 ! barbed-end actin filament capping created_by: rl creation_date: 2011-07-07T04:08:23Z [Term] id: GO:2000815 name: regulation of mRNA stability involved in response to oxidative stress namespace: biological_process def: "A process of regulation of mRNA stability that is involved in a response to oxidative stress." [GOC:obol] is_a: GO:0010610 ! regulation of mRNA stability involved in response to stress intersection_of: GO:0043488 ! regulation of mRNA stability intersection_of: part_of GO:0006979 ! response to oxidative stress relationship: part_of GO:0006979 ! response to oxidative stress created_by: midori creation_date: 2011-07-11T04:40:56Z [Term] id: GO:2000816 name: negative regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation." [GOC:obol] synonym: "negative regulation of chromosome separation during mitosis" RELATED [GOC:obol] synonym: "negative regulation of mitotic chromosome separation" RELATED [GOC:obol] synonym: "negative regulation of mitotic sister chromatid resolution" EXACT [GOC:obol] synonym: "negative regulation of sister chromatid separation during mitosis" EXACT [GOC:obol] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation is_a: GO:1905819 ! negative regulation of chromosome separation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051306 ! mitotic sister chromatid separation relationship: negatively_regulates GO:0051306 ! mitotic sister chromatid separation created_by: midori creation_date: 2011-07-11T04:45:06Z [Term] id: GO:2000817 name: regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore namespace: biological_process def: "Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol] synonym: "regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol] synonym: "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol] synonym: "regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore" EXACT [GOC:obol] synonym: "regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore" EXACT [GOC:obol] is_a: GO:2000281 ! regulation of histone H3-T3 phosphorylation intersection_of: GO:2000281 ! regulation of histone H3-T3 phosphorylation intersection_of: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore created_by: midori creation_date: 2011-07-12T11:37:40Z [Term] id: GO:2000818 name: negative regulation of myoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051450 ! myoblast proliferation relationship: negatively_regulates GO:0051450 ! myoblast proliferation created_by: pr creation_date: 2011-07-12T03:06:04Z [Term] id: GO:2000819 name: regulation of nucleotide-excision repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleotide-excision repair." [GOC:jp, PMID:18836076] synonym: "regulation of interstrand crosslink repair" RELATED [GOC:obol] synonym: "regulation of intrastrand cross-link repair" RELATED [GOC:obol] synonym: "regulation of NER" EXACT [GOC:obol] synonym: "regulation of pyrimidine-dimer repair, DNA damage excision" EXACT [GOC:obol] is_a: GO:0006282 ! regulation of DNA repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006289 ! nucleotide-excision repair relationship: regulates GO:0006289 ! nucleotide-excision repair created_by: pr creation_date: 2011-07-13T08:55:39Z [Term] id: GO:2000820 name: negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation namespace: biological_process def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] synonym: "negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II intersection_of: part_of GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0051145 ! smooth muscle cell differentiation created_by: rfoulger creation_date: 2011-07-14T08:25:05Z [Term] id: GO:2000821 name: regulation of grooming behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of grooming behavior." [GOC:BHF] synonym: "regulation of grooming behaviour" EXACT [GOC:obol] is_a: GO:0050795 ! regulation of behavior intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007625 ! grooming behavior relationship: regulates GO:0007625 ! grooming behavior created_by: rl creation_date: 2011-07-14T04:48:12Z [Term] id: GO:2000822 name: regulation of behavioral fear response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavioral fear response." [GOC:BHF] synonym: "regulation of behavioural fear response" EXACT [GOC:obol] is_a: GO:0031347 ! regulation of defense response is_a: GO:0050795 ! regulation of behavior is_a: GO:1903365 ! regulation of fear response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001662 ! behavioral fear response relationship: regulates GO:0001662 ! behavioral fear response created_by: rl creation_date: 2011-07-14T04:50:47Z [Term] id: GO:2000825 name: positive regulation of androgen receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androgen receptor activity." [GOC:obol] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004879 ! nuclear receptor activity relationship: positively_regulates GO:0004879 ! nuclear receptor activity created_by: yaf creation_date: 2011-07-15T10:56:14Z [Term] id: GO:2000826 name: regulation of heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003007 ! heart morphogenesis relationship: regulates GO:0003007 ! heart morphogenesis created_by: vk creation_date: 2011-07-19T10:08:58Z [Term] id: GO:2000827 name: mitochondrial RNA surveillance namespace: biological_process def: "The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion." [PMID:19864255] synonym: "aberrant RNA catabolic process in mitochondria" EXACT [GOC:obol] synonym: "aberrant RNA catabolic process in mitochondrion" EXACT [GOC:obol] synonym: "RNA quality control in mitochondria" EXACT [GOC:obol] synonym: "RNA quality control in mitochondrion" EXACT [GOC:obol] synonym: "RNA surveillance in mitochondria" EXACT [GOC:obol] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0071026 ! cytoplasmic RNA surveillance intersection_of: GO:0071025 ! RNA surveillance intersection_of: occurs_in GO:0005739 ! mitochondrion created_by: rfoulger creation_date: 2011-07-20T01:33:23Z [Term] id: GO:2000828 name: regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "regulation of parathormone secretion" EXACT [GOC:obol] synonym: "regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035898 ! parathyroid hormone secretion relationship: regulates GO:0035898 ! parathyroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:37:53Z [Term] id: GO:2000829 name: negative regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "negative regulation of parathormone secretion" EXACT [GOC:obol] synonym: "negative regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "negative regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000828 ! regulation of parathyroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035898 ! parathyroid hormone secretion relationship: negatively_regulates GO:0035898 ! parathyroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:37:57Z [Term] id: GO:2000830 name: positive regulation of parathyroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] synonym: "positive regulation of parathormone secretion" EXACT [GOC:obol] synonym: "positive regulation of parathyrin secretion" EXACT [GOC:obol] synonym: "positive regulation of PTH secretion" EXACT [GOC:obol] is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000828 ! regulation of parathyroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035898 ! parathyroid hormone secretion relationship: positively_regulates GO:0035898 ! parathyroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:38:00Z [Term] id: GO:2000831 name: regulation of steroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035929 ! steroid hormone secretion relationship: regulates GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:38:46Z [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035929 ! steroid hormone secretion relationship: negatively_regulates GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:38:50Z [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035929 ! steroid hormone secretion relationship: positively_regulates GO:0035929 ! steroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:38:51Z [Term] id: GO:2000834 name: regulation of androgen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035935 ! androgen secretion relationship: regulates GO:0035935 ! androgen secretion created_by: rfoulger creation_date: 2011-07-26T08:39:45Z [Term] id: GO:2000835 name: negative regulation of androgen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035935 ! androgen secretion relationship: negatively_regulates GO:0035935 ! androgen secretion created_by: rfoulger creation_date: 2011-07-26T08:39:48Z [Term] id: GO:2000836 name: positive regulation of androgen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035935 ! androgen secretion relationship: positively_regulates GO:0035935 ! androgen secretion created_by: rfoulger creation_date: 2011-07-26T08:39:51Z [Term] id: GO:2000837 name: regulation of androstenedione secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androstenedione secretion." [GOC:sl] synonym: "regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035941 ! androstenedione secretion relationship: regulates GO:0035941 ! androstenedione secretion created_by: rfoulger creation_date: 2011-07-26T08:40:36Z [Term] id: GO:2000838 name: negative regulation of androstenedione secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion." [GOC:sl] synonym: "negative regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000837 ! regulation of androstenedione secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035941 ! androstenedione secretion relationship: negatively_regulates GO:0035941 ! androstenedione secretion created_by: rfoulger creation_date: 2011-07-26T08:40:40Z [Term] id: GO:2000839 name: positive regulation of androstenedione secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androstenedione secretion." [GOC:sl] synonym: "positive regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000837 ! regulation of androstenedione secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035941 ! androstenedione secretion relationship: positively_regulates GO:0035941 ! androstenedione secretion created_by: rfoulger creation_date: 2011-07-26T08:40:42Z [Term] id: GO:2000840 name: regulation of dehydroepiandrosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] synonym: "regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] synonym: "regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] synonym: "regulation of DHEA secretion" EXACT [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035942 ! dehydroepiandrosterone secretion relationship: regulates GO:0035942 ! dehydroepiandrosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:41:29Z [Term] id: GO:2000841 name: negative regulation of dehydroepiandrosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] synonym: "negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] synonym: "negative regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] synonym: "negative regulation of DHEA secretion" EXACT [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion relationship: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:41:33Z [Term] id: GO:2000842 name: positive regulation of dehydroepiandrosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] synonym: "positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] synonym: "positive regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] synonym: "positive regulation of DHEA secretion" EXACT [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion relationship: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:41:36Z [Term] id: GO:2000843 name: regulation of testosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035936 ! testosterone secretion relationship: regulates GO:0035936 ! testosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:42:29Z [Term] id: GO:2000844 name: negative regulation of testosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000843 ! regulation of testosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035936 ! testosterone secretion relationship: negatively_regulates GO:0035936 ! testosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:42:33Z [Term] id: GO:2000845 name: positive regulation of testosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000843 ! regulation of testosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035936 ! testosterone secretion relationship: positively_regulates GO:0035936 ! testosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:42:36Z [Term] id: GO:2000846 name: regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035930 ! corticosteroid hormone secretion relationship: regulates GO:0035930 ! corticosteroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:43:38Z [Term] id: GO:2000847 name: negative regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "negative regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035930 ! corticosteroid hormone secretion relationship: negatively_regulates GO:0035930 ! corticosteroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:43:42Z [Term] id: GO:2000848 name: positive regulation of corticosteroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] synonym: "positive regulation of corticosteroid secretion" RELATED [GOC:obol] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035930 ! corticosteroid hormone secretion relationship: positively_regulates GO:0035930 ! corticosteroid hormone secretion created_by: rfoulger creation_date: 2011-07-26T08:43:45Z [Term] id: GO:2000849 name: regulation of glucocorticoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035933 ! glucocorticoid secretion relationship: regulates GO:0035933 ! glucocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:44:43Z [Term] id: GO:2000850 name: negative regulation of glucocorticoid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion is_a: GO:2000849 ! regulation of glucocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035933 ! glucocorticoid secretion relationship: negatively_regulates GO:0035933 ! glucocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:44:48Z [Term] id: GO:2000851 name: positive regulation of glucocorticoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion is_a: GO:2000849 ! regulation of glucocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035933 ! glucocorticoid secretion relationship: positively_regulates GO:0035933 ! glucocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:44:51Z [Term] id: GO:2000852 name: regulation of corticosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of corticosterone secretion." [GOC:sl] is_a: GO:2000849 ! regulation of glucocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035934 ! corticosterone secretion relationship: regulates GO:0035934 ! corticosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:45:40Z [Term] id: GO:2000853 name: negative regulation of corticosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion." [GOC:sl] is_a: GO:2000850 ! negative regulation of glucocorticoid secretion is_a: GO:2000852 ! regulation of corticosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035934 ! corticosterone secretion relationship: negatively_regulates GO:0035934 ! corticosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:45:43Z [Term] id: GO:2000854 name: positive regulation of corticosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of corticosterone secretion." [GOC:sl] is_a: GO:2000851 ! positive regulation of glucocorticoid secretion is_a: GO:2000852 ! regulation of corticosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035934 ! corticosterone secretion relationship: positively_regulates GO:0035934 ! corticosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:45:45Z [Term] id: GO:2000855 name: regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000846 ! regulation of corticosteroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035931 ! mineralocorticoid secretion relationship: regulates GO:0035931 ! mineralocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:46:38Z [Term] id: GO:2000856 name: negative regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035931 ! mineralocorticoid secretion relationship: negatively_regulates GO:0035931 ! mineralocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:46:42Z [Term] id: GO:2000857 name: positive regulation of mineralocorticoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035931 ! mineralocorticoid secretion relationship: positively_regulates GO:0035931 ! mineralocorticoid secretion created_by: rfoulger creation_date: 2011-07-26T08:46:45Z [Term] id: GO:2000858 name: regulation of aldosterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000855 ! regulation of mineralocorticoid secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035932 ! aldosterone secretion relationship: regulates GO:0035932 ! aldosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:47:27Z [Term] id: GO:2000859 name: negative regulation of aldosterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion is_a: GO:2000858 ! regulation of aldosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035932 ! aldosterone secretion relationship: negatively_regulates GO:0035932 ! aldosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:47:31Z [Term] id: GO:2000860 name: positive regulation of aldosterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [GOC:sl] is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion is_a: GO:2000858 ! regulation of aldosterone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035932 ! aldosterone secretion relationship: positively_regulates GO:0035932 ! aldosterone secretion created_by: rfoulger creation_date: 2011-07-26T08:47:34Z [Term] id: GO:2000861 name: regulation of estrogen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estrogen secretion." [GOC:sl] synonym: "regulation of oestrogen secretion" RELATED [GOC:obol] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035937 ! estrogen secretion relationship: regulates GO:0035937 ! estrogen secretion created_by: rfoulger creation_date: 2011-07-26T08:48:24Z [Term] id: GO:2000862 name: negative regulation of estrogen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion." [GOC:sl] synonym: "negative regulation of oestrogen secretion" RELATED [GOC:obol] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000861 ! regulation of estrogen secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035937 ! estrogen secretion relationship: negatively_regulates GO:0035937 ! estrogen secretion created_by: rfoulger creation_date: 2011-07-26T08:48:28Z [Term] id: GO:2000863 name: positive regulation of estrogen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of estrogen secretion." [GOC:sl] synonym: "positive regulation of oestrogen secretion" RELATED [GOC:obol] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000861 ! regulation of estrogen secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035937 ! estrogen secretion relationship: positively_regulates GO:0035937 ! estrogen secretion created_by: rfoulger creation_date: 2011-07-26T08:48:31Z [Term] id: GO:2000864 name: regulation of estradiol secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035938 ! estradiol secretion relationship: regulates GO:0035938 ! estradiol secretion created_by: rfoulger creation_date: 2011-07-26T08:49:13Z [Term] id: GO:2000865 name: negative regulation of estradiol secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "negative regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000864 ! regulation of estradiol secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035938 ! estradiol secretion relationship: negatively_regulates GO:0035938 ! estradiol secretion created_by: rfoulger creation_date: 2011-07-26T08:49:17Z [Term] id: GO:2000866 name: positive regulation of estradiol secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of estradiol secretion." [GOC:sl] synonym: "positive regulation of oestradiol secretion" EXACT [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000864 ! regulation of estradiol secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035938 ! estradiol secretion relationship: positively_regulates GO:0035938 ! estradiol secretion created_by: rfoulger creation_date: 2011-07-26T08:49:20Z [Term] id: GO:2000867 name: regulation of estrone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of estrone secretion." [GOC:sl] synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] synonym: "regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035943 ! estrone secretion relationship: regulates GO:0035943 ! estrone secretion created_by: rfoulger creation_date: 2011-07-26T08:50:11Z [Term] id: GO:2000868 name: negative regulation of estrone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion." [GOC:sl] synonym: "negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000867 ! regulation of estrone secretion is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035943 ! estrone secretion relationship: negatively_regulates GO:0035943 ! estrone secretion created_by: rfoulger creation_date: 2011-07-26T08:50:16Z [Term] id: GO:2000869 name: positive regulation of estrone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of estrone secretion." [GOC:sl] synonym: "positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000867 ! regulation of estrone secretion is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035943 ! estrone secretion relationship: positively_regulates GO:0035943 ! estrone secretion created_by: rfoulger creation_date: 2011-07-26T08:50:19Z [Term] id: GO:2000870 name: regulation of progesterone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000194 ! regulation of female gonad development is_a: GO:2000831 ! regulation of steroid hormone secretion is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042701 ! progesterone secretion relationship: regulates GO:0042701 ! progesterone secretion created_by: rfoulger creation_date: 2011-07-26T08:51:14Z [Term] id: GO:2000871 name: negative regulation of progesterone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000195 ! negative regulation of female gonad development is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042701 ! progesterone secretion relationship: negatively_regulates GO:0042701 ! progesterone secretion created_by: rfoulger creation_date: 2011-07-26T08:51:19Z [Term] id: GO:2000872 name: positive regulation of progesterone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000196 ! positive regulation of female gonad development is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042701 ! progesterone secretion relationship: positively_regulates GO:0042701 ! progesterone secretion created_by: rfoulger creation_date: 2011-07-26T08:51:22Z [Term] id: GO:2000873 name: regulation of histone H4 acetylation involved in response to DNA damage stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus." [GOC:mah] synonym: "regulation of histone H4 acetylation involved in cellular DNA damage response" EXACT [GOC:obol] synonym: "regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "regulation of histone H4 acetylation involved in DNA damage response" EXACT [GOC:obol] synonym: "regulation of histone H4 acetylation involved in response to DNA damage" EXACT [GOC:bf] synonym: "regulation of histone H4 acetylation involved in response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0090239 ! regulation of histone H4 acetylation is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000776 ! histone H4 acetylation involved in response to DNA damage stimulus relationship: regulates GO:2000776 ! histone H4 acetylation involved in response to DNA damage stimulus created_by: midori creation_date: 2011-07-26T10:05:23Z [Term] id: GO:2000874 name: regulation of glyoxylate cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] synonym: "regulation of glyoxylate bypass" EXACT [GOC:obol] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006097 ! glyoxylate cycle relationship: regulates GO:0006097 ! glyoxylate cycle created_by: rfoulger creation_date: 2011-07-27T01:27:10Z [Term] id: GO:2000875 name: negative regulation of glyoxylate cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] synonym: "negative regulation of glyoxylate bypass" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000874 ! regulation of glyoxylate cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006097 ! glyoxylate cycle relationship: negatively_regulates GO:0006097 ! glyoxylate cycle created_by: rfoulger creation_date: 2011-07-27T01:27:15Z [Term] id: GO:2000876 name: positive regulation of glyoxylate cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] synonym: "positive regulation of glyoxylate bypass" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:2000874 ! regulation of glyoxylate cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006097 ! glyoxylate cycle relationship: positively_regulates GO:0006097 ! glyoxylate cycle created_by: rfoulger creation_date: 2011-07-27T01:27:18Z [Term] id: GO:2000877 name: negative regulation of oligopeptide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport." [GOC:obol] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0090088 ! regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006857 ! oligopeptide transport relationship: negatively_regulates GO:0006857 ! oligopeptide transport created_by: rfoulger creation_date: 2011-07-27T01:54:07Z [Term] id: GO:2000878 name: positive regulation of oligopeptide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport." [GOC:obol] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0090088 ! regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006857 ! oligopeptide transport relationship: positively_regulates GO:0006857 ! oligopeptide transport created_by: rfoulger creation_date: 2011-07-27T01:54:11Z [Term] id: GO:2000879 name: negative regulation of dipeptide transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport." [GOC:obol] is_a: GO:0090089 ! regulation of dipeptide transport is_a: GO:2000877 ! negative regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042938 ! dipeptide transport relationship: negatively_regulates GO:0042938 ! dipeptide transport created_by: rfoulger creation_date: 2011-07-27T02:55:21Z [Term] id: GO:2000880 name: positive regulation of dipeptide transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport." [GOC:obol] is_a: GO:0090089 ! regulation of dipeptide transport is_a: GO:2000878 ! positive regulation of oligopeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042938 ! dipeptide transport relationship: positively_regulates GO:0042938 ! dipeptide transport created_by: rfoulger creation_date: 2011-07-27T02:55:24Z [Term] id: GO:2000881 name: regulation of starch catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "regulation of starch breakdown" EXACT [GOC:obol] synonym: "regulation of starch catabolism" EXACT [GOC:obol] synonym: "regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005983 ! starch catabolic process relationship: regulates GO:0005983 ! starch catabolic process created_by: rfoulger creation_date: 2011-07-27T03:23:39Z [Term] id: GO:2000882 name: negative regulation of starch catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "negative regulation of starch breakdown" EXACT [GOC:obol] synonym: "negative regulation of starch catabolism" EXACT [GOC:obol] synonym: "negative regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000881 ! regulation of starch catabolic process is_a: GO:2000905 ! negative regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005983 ! starch catabolic process relationship: negatively_regulates GO:0005983 ! starch catabolic process created_by: rfoulger creation_date: 2011-07-27T03:23:46Z [Term] id: GO:2000883 name: positive regulation of starch catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of starch catabolic process." [GOC:obol] synonym: "positive regulation of starch breakdown" EXACT [GOC:obol] synonym: "positive regulation of starch catabolism" EXACT [GOC:obol] synonym: "positive regulation of starch degradation" EXACT [GOC:obol] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000881 ! regulation of starch catabolic process is_a: GO:2000906 ! positive regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005983 ! starch catabolic process relationship: positively_regulates GO:0005983 ! starch catabolic process created_by: rfoulger creation_date: 2011-07-27T03:23:51Z [Term] id: GO:2000884 name: glucomannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glucomannan." [GOC:mengo_curators] synonym: "glucomannan catabolism" EXACT [GOC:obol] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0010391 ! glucomannan metabolic process is_a: GO:0042737 ! drug catabolic process created_by: jane creation_date: 2011-07-28T09:19:03Z [Term] id: GO:2000885 name: galactoglucomannan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan." [GOC:mengo_curators] synonym: "galactoglucomannan catabolism" EXACT [GOC:obol] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0010392 ! galactoglucomannan metabolic process created_by: jane creation_date: 2011-07-28T09:24:11Z [Term] id: GO:2000886 name: glucuronoxylan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan." [GOC:mengo_curators] synonym: "glucuronoxylan catabolism" EXACT [GOC:obol] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0045493 ! xylan catabolic process created_by: jane creation_date: 2011-07-28T09:37:06Z [Term] id: GO:2000887 name: glucuronoarabinoxylan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan." [GOC:mengo_curators] synonym: "glucuronoarabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:0010414 ! glucuronoarabinoxylan metabolic process is_a: GO:2000886 ! glucuronoxylan catabolic process is_a: GO:2000888 ! arabinoxylan-containing compound catabolic process created_by: jane creation_date: 2011-07-28T09:39:26Z [Term] id: GO:2000888 name: arabinoxylan-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an arabinoxylan." [GOC:mengo_curators] synonym: "arabinoxylan catabolic process" RELATED [] synonym: "arabinoxylan catabolism" RELATED [GOC:obol] is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process is_a: GO:0045493 ! xylan catabolic process created_by: jane creation_date: 2011-07-28T09:31:50Z [Term] id: GO:2000889 name: cellodextrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cellodextrin." [GOC:obol] synonym: "cellodextrin metabolism" EXACT [GOC:obol] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044042 ! glucan metabolic process created_by: jane creation_date: 2011-07-28T01:00:04Z [Term] id: GO:2000890 name: cellodextrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cellodextrin." [GOC:mengo_curators] synonym: "cellodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:2000889 ! cellodextrin metabolic process created_by: jane creation_date: 2011-07-28T01:05:21Z [Term] id: GO:2000891 name: cellobiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cellobiose." [GOC:mengo_curators] synonym: "cellobiose metabolism" EXACT [GOC:obol] is_a: GO:0005984 ! disaccharide metabolic process created_by: jane creation_date: 2011-07-28T01:35:35Z [Term] id: GO:2000892 name: cellobiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cellobiose." [GOC:mengo_curators] synonym: "cellobiose catabolism" EXACT [GOC:obol] is_a: GO:0046352 ! disaccharide catabolic process is_a: GO:2000891 ! cellobiose metabolic process created_by: jane creation_date: 2011-07-28T01:35:38Z [Term] id: GO:2000893 name: cellotriose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cellotriose." [GOC:mengo_curators] synonym: "cellotriose metabolism" EXACT [GOC:obol] is_a: GO:0009311 ! oligosaccharide metabolic process created_by: jane creation_date: 2011-07-28T02:02:44Z [Term] id: GO:2000894 name: cellotriose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cellotriose." [GOC:mengo_curators] synonym: "cellotriose catabolism" EXACT [GOC:obol] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:2000893 ! cellotriose metabolic process created_by: jane creation_date: 2011-07-28T02:02:47Z [Term] id: GO:2000895 name: hemicellulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a hemicellulose." [GOC:mengo_curators] synonym: "hemicellulose catabolism" EXACT [GOC:obol] is_a: GO:0010410 ! hemicellulose metabolic process is_a: GO:0044347 ! cell wall polysaccharide catabolic process created_by: jane creation_date: 2011-07-28T02:08:11Z [Term] id: GO:2000896 name: amylopectin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amylopectin." [GOC:mengo_curators] synonym: "Amylopectin metabolism" EXACT [GOC:obol] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: jane creation_date: 2011-07-28T02:47:25Z [Term] id: GO:2000897 name: amylopectin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amylopectin." [GOC:mengo_curators] synonym: "Amylopectin catabolism" EXACT [GOC:obol] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:2000896 ! amylopectin metabolic process created_by: jane creation_date: 2011-07-28T02:47:28Z [Term] id: GO:2000898 name: regulation of glucomannan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000884 ! glucomannan catabolic process relationship: regulates GO:2000884 ! glucomannan catabolic process created_by: trudy creation_date: 2011-07-29T01:13:16Z [Term] id: GO:2000899 name: xyloglucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a xyloglucan." [GOC:mengo_curators] synonym: "xyloglucan catabolism" EXACT [GOC:obol] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0010411 ! xyloglucan metabolic process is_a: GO:2000895 ! hemicellulose catabolic process created_by: jane creation_date: 2011-07-28T02:52:33Z [Term] id: GO:2000900 name: cyclodextrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclodextrin." [GOC:mengo_curators] synonym: "cyclodextrin metabolism" EXACT [GOC:obol] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044042 ! glucan metabolic process created_by: jane creation_date: 2011-07-28T03:19:11Z [Term] id: GO:2000901 name: cyclodextrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cyclodextrin." [GOC:mengo_curators] synonym: "cyclodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:2000900 ! cyclodextrin metabolic process created_by: jane creation_date: 2011-07-28T03:19:13Z [Term] id: GO:2000902 name: cellooligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cellooligosaccharide." [GOC:mengo_curators] synonym: "cellooligosaccharide metabolism" EXACT [GOC:obol] is_a: GO:0009311 ! oligosaccharide metabolic process created_by: jane creation_date: 2011-07-28T03:21:46Z [Term] id: GO:2000903 name: cellooligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide." [GOC:mengo_curators] synonym: "cellooligosaccharide catabolism" EXACT [GOC:obol] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:2000902 ! cellooligosaccharide metabolic process created_by: jane creation_date: 2011-07-28T03:21:49Z [Term] id: GO:2000904 name: regulation of starch metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of starch metabolic process." [GOC:obol] synonym: "regulation of starch metabolism" EXACT [GOC:obol] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005982 ! starch metabolic process relationship: regulates GO:0005982 ! starch metabolic process created_by: tanyaberardini creation_date: 2011-07-28T11:33:13Z [Term] id: GO:2000905 name: negative regulation of starch metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process." [GOC:obol] synonym: "negative regulation of starch metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005982 ! starch metabolic process relationship: negatively_regulates GO:0005982 ! starch metabolic process created_by: tanyaberardini creation_date: 2011-07-28T11:33:17Z [Term] id: GO:2000906 name: positive regulation of starch metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of starch metabolic process." [GOC:obol] synonym: "positive regulation of starch metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:2000904 ! regulation of starch metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005982 ! starch metabolic process relationship: positively_regulates GO:0005982 ! starch metabolic process created_by: tanyaberardini creation_date: 2011-07-28T11:33:19Z [Term] id: GO:2000907 name: negative regulation of glucomannan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000898 ! regulation of glucomannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000884 ! glucomannan catabolic process relationship: negatively_regulates GO:2000884 ! glucomannan catabolic process created_by: trudy creation_date: 2011-07-29T01:13:24Z [Term] id: GO:2000908 name: positive regulation of glucomannan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of glucomannan catabolism" EXACT [GOC:obol] is_a: GO:2000898 ! regulation of glucomannan catabolic process is_a: GO:2000996 ! positive regulation of mannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000884 ! glucomannan catabolic process relationship: positively_regulates GO:2000884 ! glucomannan catabolic process created_by: trudy creation_date: 2011-07-29T01:13:30Z [Term] id: GO:2000909 name: regulation of sterol import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sterol import." [GOC:obol] synonym: "regulation of sterol influx" EXACT [GOC:obol] synonym: "regulation of sterol uptake" EXACT [GOC:obol] is_a: GO:0032371 ! regulation of sterol transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035376 ! sterol import relationship: regulates GO:0035376 ! sterol import created_by: rfoulger creation_date: 2011-07-29T01:25:10Z [Term] id: GO:2000910 name: negative regulation of sterol import namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol import." [GOC:obol] synonym: "negative regulation of sterol influx" EXACT [GOC:obol] synonym: "negative regulation of sterol uptake" EXACT [GOC:obol] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:2000909 ! regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035376 ! sterol import relationship: negatively_regulates GO:0035376 ! sterol import created_by: rfoulger creation_date: 2011-07-29T01:25:14Z [Term] id: GO:2000911 name: positive regulation of sterol import namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sterol import." [GOC:obol] synonym: "positive regulation of sterol influx" EXACT [GOC:obol] synonym: "positive regulation of sterol uptake" EXACT [GOC:obol] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:2000909 ! regulation of sterol import intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035376 ! sterol import relationship: positively_regulates GO:0035376 ! sterol import created_by: rfoulger creation_date: 2011-07-29T01:25:17Z [Term] id: GO:2000912 name: regulation of galactoglucomannan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] synonym: "regulation of galactoglucomannan catabolism" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000885 ! galactoglucomannan catabolic process relationship: regulates GO:2000885 ! galactoglucomannan catabolic process created_by: trudy creation_date: 2011-07-29T07:51:31Z [Term] id: GO:2000913 name: negative regulation of galactoglucomannan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of galactoglucomannan catabolism" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process relationship: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process created_by: trudy creation_date: 2011-07-29T07:51:41Z [Term] id: GO:2000914 name: positive regulation of galactoglucomannan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of galactoglucomannan catabolism" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000885 ! galactoglucomannan catabolic process relationship: positively_regulates GO:2000885 ! galactoglucomannan catabolic process created_by: trudy creation_date: 2011-07-29T07:51:50Z [Term] id: GO:2000915 name: regulation of glucuronoxylan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] synonym: "regulation of glucuronoxylan catabolism" EXACT [GOC:obol] is_a: GO:2001000 ! regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000886 ! glucuronoxylan catabolic process relationship: regulates GO:2000886 ! glucuronoxylan catabolic process created_by: trudy creation_date: 2011-07-29T07:54:35Z [Term] id: GO:2000916 name: negative regulation of glucuronoxylan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of glucuronoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process is_a: GO:2001001 ! negative regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process relationship: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process created_by: trudy creation_date: 2011-07-29T07:54:44Z [Term] id: GO:2000917 name: positive regulation of glucuronoxylan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of glucuronoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process is_a: GO:2001002 ! positive regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000886 ! glucuronoxylan catabolic process relationship: positively_regulates GO:2000886 ! glucuronoxylan catabolic process created_by: trudy creation_date: 2011-07-29T07:54:50Z [Term] id: GO:2000918 name: regulation of glucuronoarabinoxylan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] synonym: "regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process relationship: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process created_by: trudy creation_date: 2011-08-01T12:36:47Z [Term] id: GO:2000919 name: negative regulation of glucuronoarabinoxylan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000916 ! negative regulation of glucuronoxylan catabolic process is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process is_a: GO:2000922 ! negative regulation of arabinoxylan-containing compound catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process relationship: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process created_by: trudy creation_date: 2011-08-01T12:36:53Z [Term] id: GO:2000920 name: positive regulation of glucuronoarabinoxylan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000917 ! positive regulation of glucuronoxylan catabolic process is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process is_a: GO:2000923 ! positive regulation of arabinoxylan-containing compound catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process relationship: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process created_by: trudy creation_date: 2011-08-01T12:36:58Z [Term] id: GO:2000921 name: regulation of arabinoxylan-containing compound catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] synonym: "regulation of arabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2001000 ! regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process relationship: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process created_by: trudy creation_date: 2011-08-01T12:38:56Z [Term] id: GO:2000922 name: negative regulation of arabinoxylan-containing compound catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] synonym: "negative regulation of arabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process is_a: GO:2001001 ! negative regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process relationship: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process created_by: trudy creation_date: 2011-08-01T12:39:00Z [Term] id: GO:2000923 name: positive regulation of arabinoxylan-containing compound catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] synonym: "positive regulation of arabinoxylan catabolism" EXACT [GOC:obol] is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process is_a: GO:2001002 ! positive regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process relationship: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process created_by: trudy creation_date: 2011-08-01T12:39:02Z [Term] id: GO:2000924 name: regulation of cellodextrin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] synonym: "regulation of cellodextrin metabolism" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000889 ! cellodextrin metabolic process relationship: regulates GO:2000889 ! cellodextrin metabolic process created_by: trudy creation_date: 2011-08-01T12:39:52Z [Term] id: GO:2000925 name: negative regulation of cellodextrin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellodextrin metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000924 ! regulation of cellodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000889 ! cellodextrin metabolic process relationship: negatively_regulates GO:2000889 ! cellodextrin metabolic process created_by: trudy creation_date: 2011-08-01T12:39:56Z [Term] id: GO:2000926 name: positive regulation of cellodextrin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellodextrin metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000924 ! regulation of cellodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000889 ! cellodextrin metabolic process relationship: positively_regulates GO:2000889 ! cellodextrin metabolic process created_by: trudy creation_date: 2011-08-01T12:39:59Z [Term] id: GO:2000927 name: regulation of cellodextrin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] synonym: "regulation of cellodextrin catabolism" EXACT [GOC:obol] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:2000924 ! regulation of cellodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000890 ! cellodextrin catabolic process relationship: regulates GO:2000890 ! cellodextrin catabolic process created_by: trudy creation_date: 2011-08-01T12:41:29Z [Term] id: GO:2000928 name: negative regulation of cellodextrin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process is_a: GO:2000927 ! regulation of cellodextrin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000890 ! cellodextrin catabolic process relationship: negatively_regulates GO:2000890 ! cellodextrin catabolic process created_by: trudy creation_date: 2011-08-01T12:41:33Z [Term] id: GO:2000929 name: positive regulation of cellodextrin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process is_a: GO:2000927 ! regulation of cellodextrin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000890 ! cellodextrin catabolic process relationship: positively_regulates GO:2000890 ! cellodextrin catabolic process created_by: trudy creation_date: 2011-08-01T12:41:36Z [Term] id: GO:2000930 name: regulation of cellobiose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] synonym: "regulation of cellobiose metabolism" EXACT [GOC:obol] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000891 ! cellobiose metabolic process relationship: regulates GO:2000891 ! cellobiose metabolic process created_by: trudy creation_date: 2011-08-01T12:42:53Z [Term] id: GO:2000931 name: negative regulation of cellobiose metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellobiose metabolism" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000930 ! regulation of cellobiose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000891 ! cellobiose metabolic process relationship: negatively_regulates GO:2000891 ! cellobiose metabolic process created_by: trudy creation_date: 2011-08-01T12:42:57Z [Term] id: GO:2000932 name: positive regulation of cellobiose metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellobiose metabolism" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:2000930 ! regulation of cellobiose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000891 ! cellobiose metabolic process relationship: positively_regulates GO:2000891 ! cellobiose metabolic process created_by: trudy creation_date: 2011-08-01T12:43:01Z [Term] id: GO:2000933 name: regulation of cellotriose metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] synonym: "regulation of cellotriose metabolism" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000893 ! cellotriose metabolic process relationship: regulates GO:2000893 ! cellotriose metabolic process created_by: trudy creation_date: 2011-08-01T12:44:15Z [Term] id: GO:2000934 name: negative regulation of cellotriose metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellotriose metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000933 ! regulation of cellotriose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000893 ! cellotriose metabolic process relationship: negatively_regulates GO:2000893 ! cellotriose metabolic process created_by: trudy creation_date: 2011-08-01T12:44:20Z [Term] id: GO:2000935 name: positive regulation of cellotriose metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellotriose metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000933 ! regulation of cellotriose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000893 ! cellotriose metabolic process relationship: positively_regulates GO:2000893 ! cellotriose metabolic process created_by: trudy creation_date: 2011-08-01T12:44:24Z [Term] id: GO:2000936 name: regulation of cellotriose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] synonym: "regulation of cellotriose catabolism" EXACT [GOC:obol] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:2000933 ! regulation of cellotriose metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000894 ! cellotriose catabolic process relationship: regulates GO:2000894 ! cellotriose catabolic process created_by: trudy creation_date: 2011-08-01T12:45:26Z [Term] id: GO:2000937 name: negative regulation of cellotriose catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellotriose catabolism" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:2000934 ! negative regulation of cellotriose metabolic process is_a: GO:2000936 ! regulation of cellotriose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000894 ! cellotriose catabolic process relationship: negatively_regulates GO:2000894 ! cellotriose catabolic process created_by: trudy creation_date: 2011-08-01T12:45:31Z [Term] id: GO:2000938 name: positive regulation of cellotriose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellotriose catabolism" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:2000935 ! positive regulation of cellotriose metabolic process is_a: GO:2000936 ! regulation of cellotriose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000894 ! cellotriose catabolic process relationship: positively_regulates GO:2000894 ! cellotriose catabolic process created_by: trudy creation_date: 2011-08-01T12:45:35Z [Term] id: GO:2000939 name: regulation of plant-type cell wall cellulose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] synonym: "regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0032950 ! regulation of beta-glucan metabolic process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process relationship: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process created_by: trudy creation_date: 2011-08-01T02:07:11Z [Term] id: GO:2000940 name: negative regulation of plant-type cell wall cellulose catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] synonym: "negative regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process relationship: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process created_by: trudy creation_date: 2011-08-01T02:07:17Z [Term] id: GO:2000941 name: positive regulation of plant-type cell wall cellulose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] synonym: "positive regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process relationship: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process created_by: trudy creation_date: 2011-08-01T02:07:21Z [Term] id: GO:2000942 name: regulation of amylopectin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] synonym: "regulation of Amylopectin metabolism" EXACT [GOC:obol] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000896 ! amylopectin metabolic process relationship: regulates GO:2000896 ! amylopectin metabolic process created_by: trudy creation_date: 2011-08-01T02:10:28Z [Term] id: GO:2000943 name: negative regulation of amylopectin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] synonym: "negative regulation of Amylopectin metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000942 ! regulation of amylopectin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000896 ! amylopectin metabolic process relationship: negatively_regulates GO:2000896 ! amylopectin metabolic process created_by: trudy creation_date: 2011-08-01T02:10:32Z [Term] id: GO:2000944 name: positive regulation of amylopectin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] synonym: "positive regulation of Amylopectin metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000942 ! regulation of amylopectin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000896 ! amylopectin metabolic process relationship: positively_regulates GO:2000896 ! amylopectin metabolic process created_by: trudy creation_date: 2011-08-01T02:10:36Z [Term] id: GO:2000945 name: regulation of amylopectin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] synonym: "regulation of Amylopectin catabolism" EXACT [GOC:obol] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:2000942 ! regulation of amylopectin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000897 ! amylopectin catabolic process relationship: regulates GO:2000897 ! amylopectin catabolic process created_by: trudy creation_date: 2011-08-01T02:15:22Z [Term] id: GO:2000946 name: negative regulation of amylopectin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] synonym: "negative regulation of Amylopectin catabolism" EXACT [GOC:obol] is_a: GO:2000882 ! negative regulation of starch catabolic process is_a: GO:2000943 ! negative regulation of amylopectin metabolic process is_a: GO:2000945 ! regulation of amylopectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000897 ! amylopectin catabolic process relationship: negatively_regulates GO:2000897 ! amylopectin catabolic process created_by: trudy creation_date: 2011-08-01T02:15:27Z [Term] id: GO:2000947 name: positive regulation of amylopectin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] synonym: "positive regulation of Amylopectin catabolism" EXACT [GOC:obol] is_a: GO:2000883 ! positive regulation of starch catabolic process is_a: GO:2000944 ! positive regulation of amylopectin metabolic process is_a: GO:2000945 ! regulation of amylopectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000897 ! amylopectin catabolic process relationship: positively_regulates GO:2000897 ! amylopectin catabolic process created_by: trudy creation_date: 2011-08-01T02:15:32Z [Term] id: GO:2000948 name: regulation of xyloglucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] synonym: "regulation of xyloglucan metabolism" EXACT [GOC:obol] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010411 ! xyloglucan metabolic process relationship: regulates GO:0010411 ! xyloglucan metabolic process created_by: trudy creation_date: 2011-08-01T02:16:54Z [Term] id: GO:2000949 name: negative regulation of xyloglucan metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] synonym: "negative regulation of xyloglucan metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis is_a: GO:2000948 ! regulation of xyloglucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010411 ! xyloglucan metabolic process relationship: negatively_regulates GO:0010411 ! xyloglucan metabolic process created_by: trudy creation_date: 2011-08-01T02:16:59Z [Term] id: GO:2000950 name: positive regulation of xyloglucan metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] synonym: "positive regulation of xyloglucan metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis is_a: GO:2000948 ! regulation of xyloglucan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010411 ! xyloglucan metabolic process relationship: positively_regulates GO:0010411 ! xyloglucan metabolic process created_by: trudy creation_date: 2011-08-01T02:17:02Z [Term] id: GO:2000951 name: regulation of xyloglucan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] synonym: "regulation of xyloglucan catabolism" EXACT [GOC:obol] is_a: GO:2000948 ! regulation of xyloglucan metabolic process is_a: GO:2000988 ! regulation of hemicellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000899 ! xyloglucan catabolic process relationship: regulates GO:2000899 ! xyloglucan catabolic process created_by: trudy creation_date: 2011-08-01T02:20:16Z [Term] id: GO:2000952 name: negative regulation of xyloglucan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of xyloglucan catabolism" EXACT [GOC:obol] is_a: GO:2000949 ! negative regulation of xyloglucan metabolic process is_a: GO:2000951 ! regulation of xyloglucan catabolic process is_a: GO:2000989 ! negative regulation of hemicellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000899 ! xyloglucan catabolic process relationship: negatively_regulates GO:2000899 ! xyloglucan catabolic process created_by: trudy creation_date: 2011-08-01T02:20:21Z [Term] id: GO:2000953 name: positive regulation of xyloglucan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of xyloglucan catabolism" EXACT [GOC:obol] is_a: GO:2000950 ! positive regulation of xyloglucan metabolic process is_a: GO:2000951 ! regulation of xyloglucan catabolic process is_a: GO:2000990 ! positive regulation of hemicellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000899 ! xyloglucan catabolic process relationship: positively_regulates GO:2000899 ! xyloglucan catabolic process created_by: trudy creation_date: 2011-08-01T02:20:26Z [Term] id: GO:2000954 name: regulation of cyclodextrin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] synonym: "regulation of cyclodextrin metabolism" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000900 ! cyclodextrin metabolic process relationship: regulates GO:2000900 ! cyclodextrin metabolic process created_by: trudy creation_date: 2011-08-01T02:22:00Z [Term] id: GO:2000955 name: negative regulation of cyclodextrin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] synonym: "negative regulation of cyclodextrin metabolism" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000954 ! regulation of cyclodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000900 ! cyclodextrin metabolic process relationship: negatively_regulates GO:2000900 ! cyclodextrin metabolic process created_by: trudy creation_date: 2011-08-01T02:22:05Z [Term] id: GO:2000956 name: positive regulation of cyclodextrin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] synonym: "positive regulation of cyclodextrin metabolism" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000954 ! regulation of cyclodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000900 ! cyclodextrin metabolic process relationship: positively_regulates GO:2000900 ! cyclodextrin metabolic process created_by: trudy creation_date: 2011-08-01T02:22:09Z [Term] id: GO:2000957 name: regulation of cyclodextrin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] synonym: "regulation of cyclodextrin catabolism" EXACT [GOC:obol] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:2000954 ! regulation of cyclodextrin metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000901 ! cyclodextrin catabolic process relationship: regulates GO:2000901 ! cyclodextrin catabolic process created_by: trudy creation_date: 2011-08-01T02:23:55Z [Term] id: GO:2000958 name: negative regulation of cyclodextrin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cyclodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:2000955 ! negative regulation of cyclodextrin metabolic process is_a: GO:2000957 ! regulation of cyclodextrin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000901 ! cyclodextrin catabolic process relationship: negatively_regulates GO:2000901 ! cyclodextrin catabolic process created_by: trudy creation_date: 2011-08-01T02:24:02Z [Term] id: GO:2000959 name: positive regulation of cyclodextrin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cyclodextrin catabolism" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:2000956 ! positive regulation of cyclodextrin metabolic process is_a: GO:2000957 ! regulation of cyclodextrin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000901 ! cyclodextrin catabolic process relationship: positively_regulates GO:2000901 ! cyclodextrin catabolic process created_by: trudy creation_date: 2011-08-01T02:24:06Z [Term] id: GO:2000960 name: regulation of cellooligosaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] synonym: "regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] is_a: GO:0006109 ! regulation of carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000902 ! cellooligosaccharide metabolic process relationship: regulates GO:2000902 ! cellooligosaccharide metabolic process created_by: trudy creation_date: 2011-08-01T02:25:54Z [Term] id: GO:2000961 name: negative regulation of cellooligosaccharide metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process relationship: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process created_by: trudy creation_date: 2011-08-01T02:25:59Z [Term] id: GO:2000962 name: positive regulation of cellooligosaccharide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process relationship: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process created_by: trudy creation_date: 2011-08-01T02:26:02Z [Term] id: GO:2000963 name: regulation of cellooligosaccharide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] synonym: "regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000903 ! cellooligosaccharide catabolic process relationship: regulates GO:2000903 ! cellooligosaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:28:36Z [Term] id: GO:2000964 name: negative regulation of cellooligosaccharide catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:2000961 ! negative regulation of cellooligosaccharide metabolic process is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process relationship: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:28:42Z [Term] id: GO:2000965 name: positive regulation of cellooligosaccharide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:2000962 ! positive regulation of cellooligosaccharide metabolic process is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process relationship: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:28:47Z [Term] id: GO:2000966 name: regulation of cell wall polysaccharide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] synonym: "regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044347 ! cell wall polysaccharide catabolic process relationship: regulates GO:0044347 ! cell wall polysaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:30:27Z [Term] id: GO:2000967 name: negative regulation of cell wall polysaccharide catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process relationship: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:30:33Z [Term] id: GO:2000968 name: positive regulation of cell wall polysaccharide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process relationship: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process created_by: trudy creation_date: 2011-08-01T02:30:37Z [Term] id: GO:2000969 name: positive regulation of AMPA receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity." [PMID:21423165] synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" BROAD [] is_a: GO:1900451 ! positive regulation of glutamate receptor signaling pathway is_a: GO:2000273 ! positive regulation of signaling receptor activity is_a: GO:2000311 ! regulation of AMPA receptor activity is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004971 ! AMPA glutamate receptor activity relationship: positively_regulates GO:0004971 ! AMPA glutamate receptor activity created_by: pr creation_date: 2011-08-03T10:27:08Z [Term] id: GO:2000970 name: regulation of detection of glucose namespace: biological_process def: "Any process that modulates the frequency, rate or extent of detection of glucose." [GOC:BHF] synonym: "regulation of glucose detection" EXACT [GOC:obol] synonym: "regulation of glucose perception" RELATED [GOC:obol] synonym: "regulation of glucose sensing" RELATED [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051594 ! detection of glucose relationship: regulates GO:0051594 ! detection of glucose created_by: vk creation_date: 2011-08-02T10:18:52Z [Term] id: GO:2000971 name: negative regulation of detection of glucose namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose." [GOC:BHF] synonym: "negative regulation of glucose detection" EXACT [GOC:obol] synonym: "negative regulation of glucose perception" RELATED [GOC:obol] synonym: "negative regulation of glucose sensing" RELATED [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2000970 ! regulation of detection of glucose intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051594 ! detection of glucose relationship: negatively_regulates GO:0051594 ! detection of glucose created_by: vk creation_date: 2011-08-02T10:18:54Z [Term] id: GO:2000972 name: positive regulation of detection of glucose namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of detection of glucose." [GOC:BHF] synonym: "positive regulation of glucose detection" EXACT [GOC:obol] synonym: "positive regulation of glucose perception" RELATED [GOC:obol] synonym: "positive regulation of glucose sensing" RELATED [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2000970 ! regulation of detection of glucose intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051594 ! detection of glucose relationship: positively_regulates GO:0051594 ! detection of glucose created_by: vk creation_date: 2011-08-02T10:18:56Z [Term] id: GO:2000973 name: regulation of pro-B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "regulation of pro-B cell development" RELATED [GOC:obol] synonym: "regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002328 ! pro-B cell differentiation relationship: regulates GO:0002328 ! pro-B cell differentiation created_by: yaf creation_date: 2011-08-02T03:05:45Z [Term] id: GO:2000974 name: negative regulation of pro-B cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "negative regulation of pro-B cell development" RELATED [GOC:obol] synonym: "negative regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000973 ! regulation of pro-B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002328 ! pro-B cell differentiation relationship: negatively_regulates GO:0002328 ! pro-B cell differentiation created_by: yaf creation_date: 2011-08-02T03:05:50Z [Term] id: GO:2000975 name: positive regulation of pro-B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] synonym: "positive regulation of pro-B cell development" RELATED [GOC:obol] synonym: "positive regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000973 ! regulation of pro-B cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002328 ! pro-B cell differentiation relationship: positively_regulates GO:0002328 ! pro-B cell differentiation created_by: yaf creation_date: 2011-08-02T03:05:53Z [Term] id: GO:2000976 name: obsolete regulation of transcription from RNA polymerase II promoter involved in detection of glucose namespace: biological_process def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose." [GOC:BHF] comment: This term was made obolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. synonym: "global transcription regulation from Pol II promoter involved in detection of glucose" RELATED [GOC:obol] synonym: "global transcription regulation from Pol II promoter involved in glucose detection" RELATED [GOC:obol] synonym: "global transcription regulation from Pol II promoter involved in glucose perception" RELATED [GOC:obol] synonym: "global transcription regulation from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in detection of glucose" RELATED [GOC:obol] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose detection" RELATED [GOC:obol] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol] synonym: "regulation of global transcription from Pol II promoter involved in detection of glucose" RELATED [GOC:obol] synonym: "regulation of global transcription from Pol II promoter involved in glucose detection" RELATED [GOC:obol] synonym: "regulation of global transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol] synonym: "regulation of global transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] synonym: "regulation of transcription from Pol II promoter involved in detection of glucose" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter involved in glucose detection" EXACT [GOC:obol] synonym: "regulation of transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol] synonym: "regulation of transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose detection" EXACT [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in detection of glucose" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose detection" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose perception" RELATED [GOC:obol] synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose sensing" RELATED [GOC:obol] is_obsolete: true consider: GO:0051594 created_by: vk creation_date: 2011-08-02T05:06:52Z [Term] id: GO:2000977 name: regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0021879 ! forebrain neuron differentiation relationship: regulates GO:0021879 ! forebrain neuron differentiation created_by: yaf creation_date: 2011-08-03T12:09:12Z [Term] id: GO:2000978 name: negative regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0021879 ! forebrain neuron differentiation relationship: negatively_regulates GO:0021879 ! forebrain neuron differentiation created_by: yaf creation_date: 2011-08-03T12:09:16Z [Term] id: GO:2000979 name: positive regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0021879 ! forebrain neuron differentiation relationship: positively_regulates GO:0021879 ! forebrain neuron differentiation created_by: yaf creation_date: 2011-08-03T12:09:19Z [Term] id: GO:2000980 name: regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045631 ! regulation of mechanoreceptor differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060113 ! inner ear receptor cell differentiation relationship: regulates GO:0060113 ! inner ear receptor cell differentiation created_by: yaf creation_date: 2011-08-03T02:38:43Z [Term] id: GO:2000981 name: negative regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "negative regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation relationship: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation created_by: yaf creation_date: 2011-08-03T02:38:47Z [Term] id: GO:2000982 name: positive regulation of inner ear receptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] synonym: "positive regulation of inner ear hair cell differentiation" EXACT [GOC:obol] is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0060113 ! inner ear receptor cell differentiation relationship: positively_regulates GO:0060113 ! inner ear receptor cell differentiation created_by: yaf creation_date: 2011-08-03T02:38:51Z [Term] id: GO:2000983 name: regulation of ATP citrate synthase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] synonym: "regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] synonym: "regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] synonym: "regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] synonym: "regulation of ATP-citric lyase activity" EXACT [GOC:obol] synonym: "regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] synonym: "regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] synonym: "regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] synonym: "regulation of citrate-ATP lyase activity" EXACT [GOC:obol] synonym: "regulation of citric cleavage enzyme activity" RELATED [GOC:obol] is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003878 ! ATP citrate synthase activity relationship: regulates GO:0003878 ! ATP citrate synthase activity created_by: vk creation_date: 2011-08-04T03:15:24Z [Term] id: GO:2000984 name: negative regulation of ATP citrate synthase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] synonym: "negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] synonym: "negative regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] synonym: "negative regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "negative regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "negative regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] synonym: "negative regulation of ATP-citric lyase activity" EXACT [GOC:obol] synonym: "negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] synonym: "negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] synonym: "negative regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] synonym: "negative regulation of citrate-ATP lyase activity" EXACT [GOC:obol] synonym: "negative regulation of citric cleavage enzyme activity" RELATED [GOC:obol] is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:2000983 ! regulation of ATP citrate synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003878 ! ATP citrate synthase activity relationship: negatively_regulates GO:0003878 ! ATP citrate synthase activity created_by: vk creation_date: 2011-08-04T03:15:28Z [Term] id: GO:2000985 name: positive regulation of ATP citrate synthase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] synonym: "positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] synonym: "positive regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] synonym: "positive regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "positive regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] synonym: "positive regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] synonym: "positive regulation of ATP-citric lyase activity" EXACT [GOC:obol] synonym: "positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] synonym: "positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] synonym: "positive regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] synonym: "positive regulation of citrate-ATP lyase activity" EXACT [GOC:obol] synonym: "positive regulation of citric cleavage enzyme activity" RELATED [GOC:obol] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:2000983 ! regulation of ATP citrate synthase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003878 ! ATP citrate synthase activity relationship: positively_regulates GO:0003878 ! ATP citrate synthase activity created_by: vk creation_date: 2011-08-04T03:15:31Z [Term] id: GO:2000986 name: negative regulation of behavioral fear response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response." [GOC:obol] synonym: "negative regulation of behavioural fear response" EXACT [GOC:obol] is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0048521 ! negative regulation of behavior is_a: GO:1903366 ! negative regulation of fear response is_a: GO:2000822 ! regulation of behavioral fear response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001662 ! behavioral fear response relationship: negatively_regulates GO:0001662 ! behavioral fear response created_by: yaf creation_date: 2011-08-08T09:16:34Z [Term] id: GO:2000987 name: positive regulation of behavioral fear response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavioral fear response." [GOC:obol] synonym: "positive regulation of behavioural fear response" EXACT [GOC:obol] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0048520 ! positive regulation of behavior is_a: GO:1903367 ! positive regulation of fear response is_a: GO:2000822 ! regulation of behavioral fear response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001662 ! behavioral fear response relationship: positively_regulates GO:0001662 ! behavioral fear response created_by: yaf creation_date: 2011-08-08T09:16:39Z [Term] id: GO:2000988 name: regulation of hemicellulose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] synonym: "regulation of hemicellulose catabolism" EXACT [GOC:obol] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:2000895 ! hemicellulose catabolic process relationship: regulates GO:2000895 ! hemicellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:08:16Z [Term] id: GO:2000989 name: negative regulation of hemicellulose catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] synonym: "negative regulation of hemicellulose catabolism" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process is_a: GO:2000988 ! regulation of hemicellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:2000895 ! hemicellulose catabolic process relationship: negatively_regulates GO:2000895 ! hemicellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:08:20Z [Term] id: GO:2000990 name: positive regulation of hemicellulose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] synonym: "positive regulation of hemicellulose catabolism" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process is_a: GO:2000988 ! regulation of hemicellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:2000895 ! hemicellulose catabolic process relationship: positively_regulates GO:2000895 ! hemicellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:08:23Z [Term] id: GO:2000991 name: regulation of galactomannan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051682 ! galactomannan catabolic process relationship: regulates GO:0051682 ! galactomannan catabolic process created_by: trudy creation_date: 2011-08-08T03:15:53Z [Term] id: GO:2000992 name: negative regulation of galactomannan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000991 ! regulation of galactomannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051682 ! galactomannan catabolic process relationship: negatively_regulates GO:0051682 ! galactomannan catabolic process created_by: trudy creation_date: 2011-08-08T03:16:00Z [Term] id: GO:2000993 name: positive regulation of galactomannan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:2000991 ! regulation of galactomannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051682 ! galactomannan catabolic process relationship: positively_regulates GO:0051682 ! galactomannan catabolic process created_by: trudy creation_date: 2011-08-08T03:16:07Z [Term] id: GO:2000994 name: regulation of mannan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] synonym: "regulation of mannan breakdown" EXACT [GOC:obol] synonym: "regulation of mannan catabolism" EXACT [GOC:obol] synonym: "regulation of mannan degradation" EXACT [GOC:obol] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:2000924 ! regulation of cellodextrin metabolic process is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046355 ! mannan catabolic process relationship: regulates GO:0046355 ! mannan catabolic process created_by: trudy creation_date: 2011-08-08T03:19:03Z [Term] id: GO:2000995 name: negative regulation of mannan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of mannan breakdown" EXACT [GOC:obol] synonym: "negative regulation of mannan catabolism" EXACT [GOC:obol] synonym: "negative regulation of mannan degradation" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process is_a: GO:2000994 ! regulation of mannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046355 ! mannan catabolic process relationship: negatively_regulates GO:0046355 ! mannan catabolic process created_by: trudy creation_date: 2011-08-08T03:19:11Z [Term] id: GO:2000996 name: positive regulation of mannan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of mannan breakdown" EXACT [GOC:obol] synonym: "positive regulation of mannan catabolism" EXACT [GOC:obol] synonym: "positive regulation of mannan degradation" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process is_a: GO:2000994 ! regulation of mannan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046355 ! mannan catabolic process relationship: positively_regulates GO:0046355 ! mannan catabolic process created_by: trudy creation_date: 2011-08-08T03:19:18Z [Term] id: GO:2000997 name: regulation of cellulose catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] synonym: "regulation of cellulose breakdown" EXACT [GOC:obol] synonym: "regulation of cellulose catabolism" EXACT [GOC:obol] synonym: "regulation of cellulose degradation" EXACT [GOC:obol] is_a: GO:0032950 ! regulation of beta-glucan metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030245 ! cellulose catabolic process relationship: regulates GO:0030245 ! cellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:21:20Z [Term] id: GO:2000998 name: negative regulation of cellulose catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] synonym: "negative regulation of cellulose breakdown" EXACT [GOC:obol] synonym: "negative regulation of cellulose catabolism" EXACT [GOC:obol] synonym: "negative regulation of cellulose degradation" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2000997 ! regulation of cellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030245 ! cellulose catabolic process relationship: negatively_regulates GO:0030245 ! cellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:21:26Z [Term] id: GO:2000999 name: positive regulation of cellulose catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] synonym: "positive regulation of cellulose breakdown" EXACT [GOC:obol] synonym: "positive regulation of cellulose catabolism" EXACT [GOC:obol] synonym: "positive regulation of cellulose degradation" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2000997 ! regulation of cellulose catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030245 ! cellulose catabolic process relationship: positively_regulates GO:0030245 ! cellulose catabolic process created_by: trudy creation_date: 2011-08-08T03:21:30Z [Term] id: GO:2001000 name: regulation of xylan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] synonym: "regulation of xylan breakdown" EXACT [GOC:obol] synonym: "regulation of xylan catabolism" EXACT [GOC:obol] synonym: "regulation of xylan degradation" EXACT [GOC:obol] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:2000924 ! regulation of cellodextrin metabolic process is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045493 ! xylan catabolic process relationship: regulates GO:0045493 ! xylan catabolic process created_by: trudy creation_date: 2011-08-08T03:23:13Z [Term] id: GO:2001001 name: negative regulation of xylan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of xylan breakdown" EXACT [GOC:obol] synonym: "negative regulation of xylan catabolism" EXACT [GOC:obol] synonym: "negative regulation of xylan degradation" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process is_a: GO:2001000 ! regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045493 ! xylan catabolic process relationship: negatively_regulates GO:0045493 ! xylan catabolic process created_by: trudy creation_date: 2011-08-08T03:23:18Z [Term] id: GO:2001002 name: positive regulation of xylan catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] synonym: "positive regulation of xylan breakdown" EXACT [GOC:obol] synonym: "positive regulation of xylan catabolism" EXACT [GOC:obol] synonym: "positive regulation of xylan degradation" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process is_a: GO:2001000 ! regulation of xylan catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045493 ! xylan catabolic process relationship: positively_regulates GO:0045493 ! xylan catabolic process created_by: trudy creation_date: 2011-08-08T03:23:22Z [Term] id: GO:2001003 name: regulation of pectin catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] synonym: "regulation of pectin breakdown" EXACT [GOC:obol] synonym: "regulation of pectin catabolism" EXACT [GOC:obol] synonym: "regulation of pectin degradation" EXACT [GOC:obol] is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045490 ! pectin catabolic process relationship: regulates GO:0045490 ! pectin catabolic process created_by: trudy creation_date: 2011-08-08T03:24:01Z [Term] id: GO:2001004 name: negative regulation of pectin catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol] synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol] synonym: "negative regulation of pectin degradation" EXACT [GOC:obol] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2001003 ! regulation of pectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045490 ! pectin catabolic process relationship: negatively_regulates GO:0045490 ! pectin catabolic process created_by: trudy creation_date: 2011-08-08T03:24:06Z [Term] id: GO:2001005 name: positive regulation of pectin catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol] synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol] synonym: "positive regulation of pectin degradation" EXACT [GOC:obol] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2001003 ! regulation of pectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045490 ! pectin catabolic process relationship: positively_regulates GO:0045490 ! pectin catabolic process created_by: trudy creation_date: 2011-08-08T03:24:09Z [Term] id: GO:2001006 name: regulation of cellulose biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] synonym: "regulation of cellulose anabolism" EXACT [GOC:obol] synonym: "regulation of cellulose biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellulose formation" EXACT [GOC:obol] synonym: "regulation of cellulose synthesis" EXACT [GOC:obol] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030244 ! cellulose biosynthetic process relationship: regulates GO:0030244 ! cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:42:17Z [Term] id: GO:2001007 name: negative regulation of cellulose biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] synonym: "negative regulation of cellulose anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellulose biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellulose formation" EXACT [GOC:obol] synonym: "negative regulation of cellulose synthesis" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process is_a: GO:2001006 ! regulation of cellulose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0030244 ! cellulose biosynthetic process relationship: negatively_regulates GO:0030244 ! cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:42:24Z [Term] id: GO:2001008 name: positive regulation of cellulose biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] synonym: "positive regulation of cellulose anabolism" EXACT [GOC:obol] synonym: "positive regulation of cellulose biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellulose formation" EXACT [GOC:obol] synonym: "positive regulation of cellulose synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:2001006 ! regulation of cellulose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0030244 ! cellulose biosynthetic process relationship: positively_regulates GO:0030244 ! cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:42:29Z [Term] id: GO:2001009 name: regulation of plant-type cell wall cellulose biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] synonym: "regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:2001006 ! regulation of cellulose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process relationship: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:47:15Z [Term] id: GO:2001010 name: negative regulation of plant-type cell wall cellulose biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] synonym: "negative regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis is_a: GO:2001007 ! negative regulation of cellulose biosynthetic process is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process relationship: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:47:22Z [Term] id: GO:2001011 name: positive regulation of plant-type cell wall cellulose biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] synonym: "positive regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis is_a: GO:2001008 ! positive regulation of cellulose biosynthetic process is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process relationship: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process created_by: trudy creation_date: 2011-08-08T08:47:30Z [Term] id: GO:2001012 name: mesenchymal cell differentiation involved in renal system development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol] synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: part_of GO:0072001 ! renal system development relationship: part_of GO:0072001 ! renal system development created_by: yaf creation_date: 2011-08-09T04:05:14Z [Term] id: GO:2001013 name: epithelial cell proliferation involved in renal tubule morphogenesis namespace: biological_process def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: part_of GO:0061333 ! renal tubule morphogenesis relationship: part_of GO:0061333 ! renal tubule morphogenesis created_by: yaf creation_date: 2011-08-12T11:37:29Z [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035914 ! skeletal muscle cell differentiation relationship: regulates GO:0035914 ! skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:37Z [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation relationship: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:41Z [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035914 ! skeletal muscle cell differentiation relationship: positively_regulates GO:0035914 ! skeletal muscle cell differentiation created_by: yaf creation_date: 2011-08-11T08:54:44Z [Term] id: GO:2001017 name: regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008090 ! retrograde axonal transport relationship: regulates GO:0008090 ! retrograde axonal transport created_by: kmv creation_date: 2011-08-11T09:44:42Z [Term] id: GO:2001018 name: negative regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0008090 ! retrograde axonal transport relationship: negatively_regulates GO:0008090 ! retrograde axonal transport created_by: kmv creation_date: 2011-08-11T09:44:46Z [Term] id: GO:2001019 name: positive regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0008090 ! retrograde axonal transport relationship: positively_regulates GO:0008090 ! retrograde axonal transport created_by: kmv creation_date: 2011-08-11T09:44:49Z [Term] id: GO:2001020 name: regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "regulation of DNA damage response" EXACT [GOC:obol] synonym: "regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:25Z [Term] id: GO:2001021 name: negative regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "negative regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "negative regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "negative regulation of DNA damage response" EXACT [GOC:obol] synonym: "negative regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:29Z [Term] id: GO:2001022 name: positive regulation of response to DNA damage stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] synonym: "positive regulation of cellular DNA damage response" EXACT [GOC:obol] synonym: "positive regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] synonym: "positive regulation of DNA damage response" EXACT [GOC:obol] synonym: "positive regulation of response to genotoxic stress" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001020 ! regulation of response to DNA damage stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus relationship: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus created_by: yaf creation_date: 2011-08-19T10:20:33Z [Term] id: GO:2001023 name: regulation of response to drug namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol] synonym: "regulation of drug resistance" RELATED [GOC:obol] synonym: "regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042493 ! response to drug relationship: regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:20Z [Term] id: GO:2001024 name: negative regulation of response to drug namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug." [GOC:obol] synonym: "negative regulation of drug resistance" RELATED [GOC:obol] synonym: "negative regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042493 ! response to drug relationship: negatively_regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:24Z [Term] id: GO:2001025 name: positive regulation of response to drug namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol] synonym: "positive regulation of drug resistance" RELATED [GOC:obol] synonym: "positive regulation of drug susceptibility/resistance" RELATED [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042493 ! response to drug relationship: positively_regulates GO:0042493 ! response to drug created_by: yaf creation_date: 2011-08-19T01:47:27Z [Term] id: GO:2001026 name: regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035767 ! endothelial cell chemotaxis relationship: regulates GO:0035767 ! endothelial cell chemotaxis created_by: rl creation_date: 2011-08-22T01:07:26Z [Term] id: GO:2001027 name: negative regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035767 ! endothelial cell chemotaxis relationship: negatively_regulates GO:0035767 ! endothelial cell chemotaxis created_by: rl creation_date: 2011-08-22T01:07:31Z [Term] id: GO:2001028 name: positive regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035767 ! endothelial cell chemotaxis relationship: positively_regulates GO:0035767 ! endothelial cell chemotaxis created_by: rl creation_date: 2011-08-22T01:07:34Z [Term] id: GO:2001029 name: regulation of cellular glucuronidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] synonym: "regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052695 ! cellular glucuronidation relationship: regulates GO:0052695 ! cellular glucuronidation created_by: rl creation_date: 2011-08-22T01:10:52Z [Term] id: GO:2001030 name: negative regulation of cellular glucuronidation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] synonym: "negative regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2001029 ! regulation of cellular glucuronidation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0052695 ! cellular glucuronidation relationship: negatively_regulates GO:0052695 ! cellular glucuronidation created_by: rl creation_date: 2011-08-22T01:10:56Z [Term] id: GO:2001031 name: positive regulation of cellular glucuronidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] synonym: "positive regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] synonym: "positive regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:2001029 ! regulation of cellular glucuronidation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0052695 ! cellular glucuronidation relationship: positively_regulates GO:0052695 ! cellular glucuronidation created_by: rl creation_date: 2011-08-22T01:10:59Z [Term] id: GO:2001032 name: regulation of double-strand break repair via nonhomologous end joining namespace: biological_process def: "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] synonym: "regulation of NHEJ" EXACT [GOC:obol] is_a: GO:2000779 ! regulation of double-strand break repair intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: yaf creation_date: 2011-08-24T09:25:39Z [Term] id: GO:2001033 name: negative regulation of double-strand break repair via nonhomologous end joining namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] synonym: "negative regulation of NHEJ" EXACT [GOC:obol] is_a: GO:2000780 ! negative regulation of double-strand break repair is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: yaf creation_date: 2011-08-24T09:25:46Z [Term] id: GO:2001034 name: positive regulation of double-strand break repair via nonhomologous end joining namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] synonym: "positive regulation of NHEJ" EXACT [GOC:obol] is_a: GO:2000781 ! positive regulation of double-strand break repair is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: yaf creation_date: 2011-08-24T09:25:51Z [Term] id: GO:2001035 name: regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035981 ! tongue muscle cell differentiation relationship: regulates GO:0035981 ! tongue muscle cell differentiation created_by: yaf creation_date: 2011-08-24T11:10:16Z [Term] id: GO:2001036 name: negative regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035981 ! tongue muscle cell differentiation relationship: negatively_regulates GO:0035981 ! tongue muscle cell differentiation created_by: yaf creation_date: 2011-08-24T11:10:20Z [Term] id: GO:2001037 name: positive regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035981 ! tongue muscle cell differentiation relationship: positively_regulates GO:0035981 ! tongue muscle cell differentiation created_by: yaf creation_date: 2011-08-24T11:10:22Z [Term] id: GO:2001038 name: regulation of cellular response to drug namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to drug." [GOC:obol] is_a: GO:0050794 ! regulation of cellular process is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035690 ! cellular response to drug relationship: regulates GO:0035690 ! cellular response to drug created_by: yaf creation_date: 2011-08-27T04:12:19Z [Term] id: GO:2001039 name: negative regulation of cellular response to drug namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug." [GOC:obol] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2001024 ! negative regulation of response to drug is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035690 ! cellular response to drug relationship: negatively_regulates GO:0035690 ! cellular response to drug created_by: yaf creation_date: 2011-08-27T04:12:23Z [Term] id: GO:2001040 name: positive regulation of cellular response to drug namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to drug." [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2001025 ! positive regulation of response to drug is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035690 ! cellular response to drug relationship: positively_regulates GO:0035690 ! cellular response to drug created_by: yaf creation_date: 2011-08-27T04:12:25Z [Term] id: GO:2001042 name: negative regulation of septum digestion after cytokinesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] synonym: "negative regulation of cytokinetic cell separation" EXACT [] is_a: GO:0010590 ! regulation of septum digestion after cytokinesis is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0000920 ! septum digestion after cytokinesis relationship: negatively_regulates GO:0000920 ! septum digestion after cytokinesis created_by: mcc creation_date: 2011-08-30T05:16:55Z [Term] id: GO:2001043 name: positive regulation of septum digestion after cytokinesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] synonym: "positive regulation of cell separation after cytokinesis" RELATED [] synonym: "positive regulation of cytokinetic cell separation" RELATED [] is_a: GO:0010590 ! regulation of septum digestion after cytokinesis is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0000920 ! septum digestion after cytokinesis relationship: positively_regulates GO:0000920 ! septum digestion after cytokinesis created_by: mcc creation_date: 2011-08-30T05:16:57Z [Term] id: GO:2001044 name: regulation of integrin-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] synonym: "regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007229 ! integrin-mediated signaling pathway relationship: regulates GO:0007229 ! integrin-mediated signaling pathway created_by: rfoulger creation_date: 2011-08-31T03:49:11Z [Term] id: GO:2001045 name: negative regulation of integrin-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] synonym: "negative regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway relationship: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway created_by: rfoulger creation_date: 2011-08-31T03:49:16Z [Term] id: GO:2001046 name: positive regulation of integrin-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] synonym: "positive regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007229 ! integrin-mediated signaling pathway relationship: positively_regulates GO:0007229 ! integrin-mediated signaling pathway created_by: rfoulger creation_date: 2011-08-31T03:49:19Z [Term] id: GO:2001049 name: regulation of tendon cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035990 ! tendon cell differentiation relationship: regulates GO:0035990 ! tendon cell differentiation created_by: yaf creation_date: 2011-09-01T09:20:32Z [Term] id: GO:2001050 name: negative regulation of tendon cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035990 ! tendon cell differentiation relationship: negatively_regulates GO:0035990 ! tendon cell differentiation created_by: yaf creation_date: 2011-09-01T09:20:38Z [Term] id: GO:2001051 name: positive regulation of tendon cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035990 ! tendon cell differentiation relationship: positively_regulates GO:0035990 ! tendon cell differentiation created_by: yaf creation_date: 2011-09-01T09:20:42Z [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097152 ! mesenchymal cell apoptotic process relationship: regulates GO:0097152 ! mesenchymal cell apoptotic process created_by: yaf creation_date: 2011-09-08T02:49:59Z [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process relationship: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process created_by: yaf creation_date: 2011-09-08T02:50:05Z [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process created_by: yaf creation_date: 2011-09-08T02:50:09Z [Term] id: GO:2001056 name: positive regulation of cysteine-type endopeptidase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol] synonym: "positive regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] synonym: "positive regulation of thiol endopeptidase activity" EXACT [GOC:obol] is_a: GO:0010950 ! positive regulation of endopeptidase activity is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0004197 ! cysteine-type endopeptidase activity relationship: positively_regulates GO:0004197 ! cysteine-type endopeptidase activity created_by: pr creation_date: 2011-09-09T08:53:43Z [Term] id: GO:2001057 name: reactive nitrogen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive nitrogen species." [GOC:obol] synonym: "reactive nitrogen species metabolism" EXACT [GOC:obol] synonym: "RNS metabolic process" EXACT [GOC:obol] synonym: "RNS metabolism" EXACT [GOC:obol] is_a: GO:0006807 ! nitrogen compound metabolic process created_by: jane creation_date: 2011-09-09T01:29:13Z [Term] id: GO:2001058 name: D-tagatose 6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a D-tagatose 6-phosphate." [GOC:obol] synonym: "D-tagatose 6-phosphate metabolism" EXACT [GOC:obol] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: jane creation_date: 2011-09-09T03:21:28Z [Term] id: GO:2001059 name: D-tagatose 6-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate." [GOC:mengo_curators] synonym: "D-tagatose 6-phosphate catabolism" EXACT [GOC:obol] xref: UniPathway:UPA00704 is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:2001058 ! D-tagatose 6-phosphate metabolic process created_by: jane creation_date: 2011-09-09T03:21:33Z [Term] id: GO:2001060 name: D-glycero-D-manno-heptose 7-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators] synonym: "D-glycero-D-manno-heptose 7-phosphate metabolism" EXACT [GOC:obol] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process created_by: jane creation_date: 2011-09-09T03:29:03Z [Term] id: GO:2001061 name: D-glycero-D-manno-heptose 7-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators] synonym: "D-glycero-D-manno-heptose 7-phosphate biosynthesis" EXACT [GOC:obol] xref: UniPathway:UPA00041 is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:2001060 ! D-glycero-D-manno-heptose 7-phosphate metabolic process created_by: jane creation_date: 2011-09-09T03:29:08Z [Term] id: GO:2001062 name: xylan binding namespace: molecular_function def: "Interacting selectively and non-covalently with xylan." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-14T10:10:04Z [Term] id: GO:2001063 name: glucomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with glucomannan." [GOC:mengo_curators] is_a: GO:0008144 ! drug binding is_a: GO:0010297 ! heteropolysaccharide binding created_by: jane creation_date: 2011-09-14T10:29:45Z [Term] id: GO:2001064 name: cellooligosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellooligosaccharide." [GOC:mengo_curators] is_a: GO:0070492 ! oligosaccharide binding created_by: jane creation_date: 2011-09-14T10:32:19Z [Term] id: GO:2001065 name: mannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannan." [GOC:mengo_curators] synonym: "mannoglycan binding" RELATED [GOC:obol] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-14T10:49:45Z [Term] id: GO:2001066 name: amylopectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with amylopectin." [GOC:mengo_curators] is_a: GO:0097367 ! carbohydrate derivative binding created_by: jane creation_date: 2011-09-14T11:46:37Z [Term] id: GO:2001067 name: pullulan binding namespace: molecular_function def: "Interacting selectively and non-covalently with pullulan." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-14T11:50:06Z [Term] id: GO:2001068 name: arabinoxylan binding namespace: molecular_function def: "Interacting selectively and non-covalently with arabinoxylan." [GOC:mengo_curators] is_a: GO:2001062 ! xylan binding created_by: jane creation_date: 2011-09-14T11:58:38Z [Term] id: GO:2001069 name: glycogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycogen." [GOC:mengo_curators] synonym: "animal starch binding" RELATED [GOC:obol] synonym: "liver starch binding" RELATED [GOC:obol] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-14T12:01:06Z [Term] id: GO:2001070 name: starch binding namespace: molecular_function def: "Interacting selectively and non-covalently with starch." [GOC:mengo_curators] synonym: "amidon binding" RELATED [GOC:obol] synonym: "amylum binding" RELATED [GOC:obol] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-14T12:02:50Z [Term] id: GO:2001071 name: maltoheptaose binding namespace: molecular_function def: "Interacting selectively and non-covalently with maltoheptaose." [GOC:mengo_curators] is_a: GO:0070492 ! oligosaccharide binding created_by: jane creation_date: 2011-09-14T12:04:30Z [Term] id: GO:2001072 name: galactomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with galactomannan." [GOC:mengo_curators] is_a: GO:0010297 ! heteropolysaccharide binding created_by: jane creation_date: 2011-09-14T12:12:02Z [Term] id: GO:2001073 name: cyclodextrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclodextrin." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding is_a: GO:0070492 ! oligosaccharide binding created_by: jane creation_date: 2011-09-14T12:24:30Z [Term] id: GO:2001074 name: regulation of metanephric ureteric bud development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] is_a: GO:0061217 ! regulation of mesonephros development is_a: GO:0072215 ! regulation of metanephros development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035502 ! metanephric part of ureteric bud development relationship: regulates GO:0035502 ! metanephric part of ureteric bud development created_by: yaf creation_date: 2011-09-14T01:11:06Z [Term] id: GO:2001075 name: negative regulation of metanephric ureteric bud development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] is_a: GO:0061218 ! negative regulation of mesonephros development is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:2001074 ! regulation of metanephric ureteric bud development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development relationship: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development created_by: yaf creation_date: 2011-09-14T01:11:12Z [Term] id: GO:2001076 name: positive regulation of metanephric ureteric bud development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] is_a: GO:0061213 ! positive regulation of mesonephros development is_a: GO:0072216 ! positive regulation of metanephros development is_a: GO:0110110 ! positive regulation of animal organ morphogenesis is_a: GO:2001074 ! regulation of metanephric ureteric bud development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035502 ! metanephric part of ureteric bud development relationship: positively_regulates GO:0035502 ! metanephric part of ureteric bud development created_by: yaf creation_date: 2011-09-14T01:11:15Z [Term] id: GO:2001077 name: (1->3),(1->4)-beta-glucan binding namespace: molecular_function def: "Interacting selectively and non-covalently with (1->3),(1->4)-beta-glucan." [GOC:mengo_curators] synonym: "(1,3),(1,4)-beta-glucan binding" EXACT [] synonym: "1->3,1->4-beta-glucan binding" EXACT [] synonym: "beta-(1,3),(1,4)-glucan binding" EXACT [] synonym: "beta-(1->3),(1->4)-glucan binding" EXACT [] synonym: "beta-1,3-1,4-glucan binding" EXACT [] synonym: "beta-1->3,1->4-glucan binding" EXACT [] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T09:07:33Z [Term] id: GO:2001078 name: (1->6)-beta-D-glucan binding namespace: molecular_function def: "Interacting selectively and non-covalently with (1->6)-beta-D-glucan." [GOC:mengo_curators] synonym: "(1,6)-beta-D-glucan binding" EXACT [] synonym: "1,6-beta-D-glucan binding" EXACT [] synonym: "1->6-beta-D-glucan binding" EXACT [] synonym: "beta-(1,6)-D-glucan binding" EXACT [] synonym: "beta-(1->6)-D-glucan binding" EXACT [] synonym: "beta-1,6-D-glucan binding" EXACT [] synonym: "beta-1->6-D-glucan binding" EXACT [] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T01:12:50Z [Term] id: GO:2001079 name: beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc." [GOC:mengo_curators] is_a: GO:0097367 ! carbohydrate derivative binding created_by: jane creation_date: 2011-09-15T01:15:19Z [Term] id: GO:2001080 name: chitosan binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitosan." [GOC:mengo_curators] is_a: GO:0070405 ! ammonium ion binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: jane creation_date: 2011-09-15T01:17:32Z [Term] id: GO:2001081 name: (1->4)-beta-D-galactan binding namespace: molecular_function def: "Interacting selectively and non-covalently with (1->4)-beta-D-galactan." [GOC:mengo_curators] synonym: "(1,4)-beta-D-galactan binding" EXACT [] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T01:21:50Z [Term] id: GO:2001082 name: inulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with inulin." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T01:23:59Z [Term] id: GO:2001083 name: alpha-D-glucan binding namespace: molecular_function def: "Interacting selectively and non-covalently with alpha-D-glucan." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T01:26:14Z [Term] id: GO:2001084 name: L-arabinofuranose binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-arabinofuranose." [GOC:mengo_curators] is_a: GO:0048029 ! monosaccharide binding created_by: jane creation_date: 2011-09-15T01:33:53Z [Term] id: GO:2001085 name: arabinogalactan binding namespace: molecular_function def: "Interacting selectively and non-covalently with arabinogalactan." [GOC:mengo_curators] is_a: GO:0030247 ! polysaccharide binding created_by: jane creation_date: 2011-09-15T01:35:51Z [Term] id: GO:2001086 name: laminarabiose transport namespace: biological_process def: "The directed movement of a laminarabioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015766 ! disaccharide transport created_by: jane creation_date: 2011-09-21T12:55:01Z [Term] id: GO:2001087 name: sophorose transport namespace: biological_process def: "The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015766 ! disaccharide transport created_by: jane creation_date: 2011-09-21T12:58:08Z [Term] id: GO:2001088 name: trisaccharide transport namespace: biological_process def: "The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015772 ! oligosaccharide transport created_by: jane creation_date: 2011-09-21T12:59:46Z [Term] id: GO:2001089 name: maltotriose transport namespace: biological_process def: "The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T01:24:26Z [Term] id: GO:2001090 name: maltotriulose transport namespace: biological_process def: "The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T01:44:15Z [Term] id: GO:2001091 name: nigerotriose transport namespace: biological_process def: "The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T01:51:49Z [Term] id: GO:2001092 name: arabinotriose transport namespace: biological_process def: "The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T01:59:36Z [Term] id: GO:2001093 name: galactotriose transport namespace: biological_process def: "The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T02:01:29Z [Term] id: GO:2001094 name: xylotriose transport namespace: biological_process def: "The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T02:03:26Z [Term] id: GO:2001095 name: mannotriose transport namespace: biological_process def: "The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T02:04:52Z [Term] id: GO:2001096 name: cellotriose transport namespace: biological_process def: "The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T02:06:27Z [Term] id: GO:2001097 name: laminaritriose transport namespace: biological_process def: "The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001088 ! trisaccharide transport created_by: jane creation_date: 2011-09-21T02:11:36Z [Term] id: GO:2001098 name: tetrasaccharide transport namespace: biological_process def: "The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015772 ! oligosaccharide transport created_by: jane creation_date: 2011-09-21T02:12:53Z [Term] id: GO:2001099 name: maltotetraose transport namespace: biological_process def: "The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001098 ! tetrasaccharide transport created_by: jane creation_date: 2011-09-21T02:15:03Z [Term] id: GO:2001100 name: pentasaccharide transport namespace: biological_process def: "The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015772 ! oligosaccharide transport created_by: jane creation_date: 2011-09-21T02:17:07Z [Term] id: GO:2001101 name: maltopentaose transport namespace: biological_process def: "The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001100 ! pentasaccharide transport created_by: jane creation_date: 2011-09-21T02:18:36Z [Term] id: GO:2001102 name: hexasaccharide transport namespace: biological_process def: "The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015772 ! oligosaccharide transport created_by: jane creation_date: 2011-09-21T02:20:31Z [Term] id: GO:2001103 name: maltohexaose transport namespace: biological_process def: "The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001102 ! hexasaccharide transport created_by: jane creation_date: 2011-09-21T02:21:40Z [Term] id: GO:2001104 name: heptasaccharide transport namespace: biological_process def: "The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:0015772 ! oligosaccharide transport created_by: jane creation_date: 2011-09-21T02:29:58Z [Term] id: GO:2001105 name: maltoheptaose transport namespace: biological_process def: "The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] is_a: GO:2001104 ! heptasaccharide transport created_by: jane creation_date: 2011-09-21T02:31:22Z [Term] id: GO:2001106 name: regulation of Rho guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] synonym: "regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] synonym: "regulation of RhoGEF" EXACT [GOC:obol] is_a: GO:1904475 ! regulation of Ras GTPase binding is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity relationship: regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity created_by: yaf creation_date: 2011-09-23T10:13:06Z [Term] id: GO:2001107 name: negative regulation of Rho guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] synonym: "negative regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] synonym: "negative regulation of RhoGEF" EXACT [GOC:obol] is_a: GO:1904476 ! negative regulation of Ras GTPase binding is_a: GO:1905098 ! negative regulation of guanyl-nucleotide exchange factor activity is_a: GO:2001106 ! regulation of Rho guanyl-nucleotide exchange factor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity relationship: negatively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity created_by: yaf creation_date: 2011-09-23T10:13:12Z [Term] id: GO:2001108 name: positive regulation of Rho guanyl-nucleotide exchange factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] synonym: "positive regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] synonym: "positive regulation of RhoGEF" EXACT [GOC:obol] is_a: GO:1904477 ! positive regulation of Ras GTPase binding is_a: GO:1905099 ! positive regulation of guanyl-nucleotide exchange factor activity is_a: GO:2001106 ! regulation of Rho guanyl-nucleotide exchange factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity relationship: positively_regulates GO:0005089 ! Rho guanyl-nucleotide exchange factor activity created_by: yaf creation_date: 2011-09-23T10:13:16Z [Term] id: GO:2001109 name: regulation of lens epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] is_a: GO:0050678 ! regulation of epithelial cell proliferation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097166 ! lens epithelial cell proliferation relationship: regulates GO:0097166 ! lens epithelial cell proliferation created_by: yaf creation_date: 2011-09-30T02:04:53Z [Term] id: GO:2001110 name: negative regulation of lens epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2001109 ! regulation of lens epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097166 ! lens epithelial cell proliferation relationship: negatively_regulates GO:0097166 ! lens epithelial cell proliferation created_by: yaf creation_date: 2011-09-30T02:04:57Z [Term] id: GO:2001111 name: positive regulation of lens epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2001109 ! regulation of lens epithelial cell proliferation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097166 ! lens epithelial cell proliferation relationship: positively_regulates GO:0097166 ! lens epithelial cell proliferation created_by: yaf creation_date: 2011-09-30T02:04:59Z [Term] id: GO:2001112 name: regulation of cellular response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] synonym: "regulation of cellular response to HGF stimulus" EXACT [GOC:obol] is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus relationship: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus created_by: dph creation_date: 2011-10-05T05:43:18Z [Term] id: GO:2001113 name: negative regulation of cellular response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] synonym: "negative regulation of cellular response to HGF stimulus" EXACT [GOC:obol] is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus relationship: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus created_by: dph creation_date: 2011-10-05T05:43:23Z [Term] id: GO:2001114 name: positive regulation of cellular response to hepatocyte growth factor stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] synonym: "positive regulation of cellular response to HGF stimulus" EXACT [GOC:obol] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus relationship: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus created_by: dph creation_date: 2011-10-05T05:43:26Z [Term] id: GO:2001115 name: methanopterin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a methanopterin." [GOC:mengo_curators] synonym: "methanopterin metabolism" EXACT [GOC:obol] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process created_by: jane creation_date: 2011-10-11T11:54:56Z [Term] id: GO:2001116 name: methanopterin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methanopterin." [GOC:mengo_curators] synonym: "methanopterin biosynthesis" EXACT [GOC:obol] is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:2001115 ! methanopterin-containing compound metabolic process created_by: jane creation_date: 2011-10-11T11:55:00Z [Term] id: GO:2001117 name: tetrahydromethanopterin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a tetrahydromethanopterin." [GOC:mengo_curators] synonym: "tetrahydromethanopterin metabolism" EXACT [GOC:obol] is_a: GO:2001115 ! methanopterin-containing compound metabolic process created_by: jane creation_date: 2011-10-11T12:13:15Z [Term] id: GO:2001118 name: tetrahydromethanopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin." [GOC:mengo_curators] synonym: "tetrahydromethanopterin biosynthesis" EXACT [GOC:obol] is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process is_a: GO:2001117 ! tetrahydromethanopterin metabolic process created_by: jane creation_date: 2011-10-11T12:13:19Z [Term] id: GO:2001119 name: methanofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a methanofuran." [GOC:mengo_curators] synonym: "methanofuran metabolism" EXACT [GOC:obol] is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: jane creation_date: 2011-10-11T12:34:08Z [Term] id: GO:2001120 name: methanofuran biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methanofuran." [GOC:mengo_curators] synonym: "methanofuran biosynthesis" EXACT [GOC:obol] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:2001119 ! methanofuran metabolic process created_by: jane creation_date: 2011-10-11T12:34:12Z [Term] id: GO:2001121 name: coenzyme gamma-F420-2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators] synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process created_by: jane creation_date: 2011-10-11T02:38:14Z [Term] id: GO:2001122 name: maltoheptaose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a maltoheptaose." [GOC:mengo_curators] synonym: "maltoheptaose metabolism" EXACT [GOC:obol] is_a: GO:0009311 ! oligosaccharide metabolic process created_by: jane creation_date: 2011-10-11T02:41:26Z [Term] id: GO:2001123 name: maltoheptaose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a maltoheptaose." [GOC:mengo_curators] synonym: "maltoheptaose catabolism" EXACT [GOC:obol] is_a: GO:0009313 ! oligosaccharide catabolic process is_a: GO:2001122 ! maltoheptaose metabolic process created_by: jane creation_date: 2011-10-11T02:41:29Z [Term] id: GO:2001124 name: regulation of translational frameshifting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational frameshifting." [GOC:obol] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006452 ! translational frameshifting relationship: regulates GO:0006452 ! translational frameshifting created_by: dph creation_date: 2011-10-12T05:52:22Z [Term] id: GO:2001125 name: negative regulation of translational frameshifting namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting." [GOC:obol] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:2001124 ! regulation of translational frameshifting intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006452 ! translational frameshifting relationship: negatively_regulates GO:0006452 ! translational frameshifting created_by: dph creation_date: 2011-10-12T05:52:27Z [Term] id: GO:2001126 name: positive regulation of translational frameshifting namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational frameshifting." [GOC:obol] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:2001124 ! regulation of translational frameshifting intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006452 ! translational frameshifting relationship: positively_regulates GO:0006452 ! translational frameshifting created_by: dph creation_date: 2011-10-12T05:52:30Z [Term] id: GO:2001127 name: methane biosynthetic process from formic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a formic acid." [GOC:mengo_curators] is_a: GO:0015942 ! formate metabolic process is_a: GO:0015948 ! methanogenesis created_by: jane creation_date: 2011-10-13T09:54:03Z [Term] id: GO:2001128 name: methane biosynthetic process from methylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a methylamine." [GOC:mengo_curators] is_a: GO:0015948 ! methanogenesis is_a: GO:0030416 ! methylamine metabolic process created_by: jane creation_date: 2011-10-13T10:23:25Z [Term] id: GO:2001129 name: methane biosynthetic process from dimethylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine." [GOC:mengo_curators] is_a: GO:0009308 ! amine metabolic process is_a: GO:0015948 ! methanogenesis is_a: GO:0097164 ! ammonium ion metabolic process created_by: jane creation_date: 2011-10-13T10:26:13Z [Term] id: GO:2001130 name: methane biosynthetic process from trimethylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine." [GOC:mengo_curators] is_a: GO:0009308 ! amine metabolic process is_a: GO:0015948 ! methanogenesis is_a: GO:0097164 ! ammonium ion metabolic process created_by: jane creation_date: 2011-10-13T10:28:03Z [Term] id: GO:2001131 name: methane biosynthetic process from dimethyl sulfide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide." [GOC:mengo_curators] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0015948 ! methanogenesis created_by: jane creation_date: 2011-10-13T10:44:31Z [Term] id: GO:2001132 name: methane biosynthetic process from 3-(methylthio)propionic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009404 ! toxin metabolic process is_a: GO:0015948 ! methanogenesis created_by: jane creation_date: 2011-10-13T12:19:33Z [Term] id: GO:2001133 name: methane biosynthetic process from methanethiol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a methanethiol." [GOC:mengo_curators] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0015948 ! methanogenesis created_by: jane creation_date: 2011-10-13T12:32:57Z [Term] id: GO:2001134 name: methane biosynthetic process from carbon monoxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators] is_a: GO:0015948 ! methanogenesis is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process created_by: jane creation_date: 2011-10-13T12:36:20Z [Term] id: GO:2001135 name: regulation of endocytic recycling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol] synonym: "regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032456 ! endocytic recycling relationship: regulates GO:0032456 ! endocytic recycling created_by: kmv creation_date: 2011-10-14T03:34:36Z [Term] id: GO:2001136 name: negative regulation of endocytic recycling namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol] synonym: "negative regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2001135 ! regulation of endocytic recycling intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032456 ! endocytic recycling relationship: negatively_regulates GO:0032456 ! endocytic recycling created_by: kmv creation_date: 2011-10-14T03:34:43Z [Term] id: GO:2001137 name: positive regulation of endocytic recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytic recycling." [GOC:obol] synonym: "positive regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2001135 ! regulation of endocytic recycling intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032456 ! endocytic recycling relationship: positively_regulates GO:0032456 ! endocytic recycling created_by: kmv creation_date: 2011-10-14T03:34:49Z [Term] id: GO:2001138 name: regulation of phospholipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipid transport." [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015914 ! phospholipid transport relationship: regulates GO:0015914 ! phospholipid transport created_by: kmv creation_date: 2011-10-14T06:16:06Z [Term] id: GO:2001139 name: negative regulation of phospholipid transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport." [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:2001138 ! regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015914 ! phospholipid transport relationship: negatively_regulates GO:0015914 ! phospholipid transport created_by: kmv creation_date: 2011-10-14T06:16:11Z [Term] id: GO:2001140 name: positive regulation of phospholipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phospholipid transport." [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:1903793 ! positive regulation of anion transport is_a: GO:2001138 ! regulation of phospholipid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015914 ! phospholipid transport relationship: positively_regulates GO:0015914 ! phospholipid transport created_by: kmv creation_date: 2011-10-14T06:16:14Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032774 ! RNA biosynthetic process relationship: regulates GO:0032774 ! RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001142 name: nicotinate transport namespace: biological_process def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport created_by: tanyaberardini creation_date: 2011-10-18T05:09:50Z [Term] id: GO:2001143 name: N-methylnicotinate transport namespace: biological_process def: "The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol] is_a: GO:0015697 ! quaternary ammonium group transport created_by: tanyaberardini creation_date: 2011-10-18T05:16:08Z [Term] id: GO:2001144 name: regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] is_a: GO:0010921 ! regulation of phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity relationship: regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity created_by: yaf creation_date: 2011-10-19T10:41:25Z [Term] id: GO:2001145 name: negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity relationship: negatively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity created_by: yaf creation_date: 2011-10-19T10:41:28Z [Term] id: GO:2001146 name: positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity relationship: positively_regulates GO:0034485 ! phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity created_by: yaf creation_date: 2011-10-19T10:41:30Z [Term] id: GO:2001147 name: camalexin binding namespace: molecular_function def: "Interacting selectively and non-covalently with camalexin." [GOC:obol] synonym: "3-(1,3-thiazol-2-yl)-1H-indole binding" EXACT [GOC:obol] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding created_by: tanyaberardini creation_date: 2011-10-19T10:54:19Z [Term] id: GO:2001148 name: regulation of dipeptide transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] synonym: "regulation of dipeptide membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0090089 ! regulation of dipeptide transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035442 ! dipeptide transmembrane transport relationship: regulates GO:0035442 ! dipeptide transmembrane transport created_by: kmv creation_date: 2011-10-21T04:34:20Z [Term] id: GO:2001149 name: negative regulation of dipeptide transmembrane transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] synonym: "negative regulation of dipeptide membrane transport" EXACT [] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:2000879 ! negative regulation of dipeptide transport is_a: GO:2001148 ! regulation of dipeptide transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035442 ! dipeptide transmembrane transport relationship: negatively_regulates GO:0035442 ! dipeptide transmembrane transport created_by: kmv creation_date: 2011-10-21T06:09:59Z [Term] id: GO:2001150 name: positive regulation of dipeptide transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] synonym: "positive regulation of dipeptide membrane transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:2000880 ! positive regulation of dipeptide transport is_a: GO:2001148 ! regulation of dipeptide transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035442 ! dipeptide transmembrane transport relationship: positively_regulates GO:0035442 ! dipeptide transmembrane transport created_by: kmv creation_date: 2011-10-21T06:10:03Z [Term] id: GO:2001151 name: regulation of renal water transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0050878 ! regulation of body fluid levels is_a: GO:0051049 ! regulation of transport is_a: GO:0098801 ! regulation of renal system process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003097 ! renal water transport relationship: regulates GO:0003097 ! renal water transport created_by: yaf creation_date: 2011-10-24T11:37:51Z [Term] id: GO:2001152 name: negative regulation of renal water transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2001151 ! regulation of renal water transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0003097 ! renal water transport relationship: negatively_regulates GO:0003097 ! renal water transport created_by: yaf creation_date: 2011-10-24T11:37:57Z [Term] id: GO:2001153 name: positive regulation of renal water transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [GOC:obol] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2001151 ! regulation of renal water transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003097 ! renal water transport relationship: positively_regulates GO:0003097 ! renal water transport created_by: yaf creation_date: 2011-10-24T11:38:01Z [Term] id: GO:2001154 name: regulation of glycolytic fermentation to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] synonym: "regulation of ethanol fermentation" EXACT [GOC:obol] synonym: "regulation of glucose fermentation to ethanol" EXACT [GOC:obol] is_a: GO:0043465 ! regulation of fermentation is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019655 ! glycolytic fermentation to ethanol relationship: regulates GO:0019655 ! glycolytic fermentation to ethanol created_by: mcc creation_date: 2011-10-27T02:39:00Z [Term] id: GO:2001155 name: negative regulation of glycolytic fermentation to ethanol namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] synonym: "negative regulation of ethanol fermentation" EXACT [GOC:obol] synonym: "negative regulation of glucose fermentation to ethanol" EXACT [GOC:obol] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:1901003 ! negative regulation of fermentation is_a: GO:1903579 ! negative regulation of ATP metabolic process is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol relationship: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol created_by: mcc creation_date: 2011-10-27T02:39:05Z [Term] id: GO:2001156 name: regulation of proline catabolic process to glutamate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] synonym: "regulation of proline breakdown to glutamate" EXACT [GOC:obol] synonym: "regulation of proline degradation to glutamate" EXACT [GOC:obol] synonym: "regulation of proline oxidation" RELATED [GOC:obol] is_a: GO:0033241 ! regulation of cellular amine catabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process is_a: GO:2000214 ! regulation of proline metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010133 ! proline catabolic process to glutamate relationship: regulates GO:0010133 ! proline catabolic process to glutamate created_by: mcc creation_date: 2011-10-25T08:54:37Z [Term] id: GO:2001157 name: negative regulation of proline catabolic process to glutamate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] synonym: "negative regulation of proline breakdown to glutamate" EXACT [GOC:obol] synonym: "negative regulation of proline degradation to glutamate" EXACT [GOC:obol] synonym: "negative regulation of proline oxidation" RELATED [GOC:obol] is_a: GO:0033242 ! negative regulation of cellular amine catabolic process is_a: GO:2000212 ! negative regulation of glutamate metabolic process is_a: GO:2000215 ! negative regulation of proline metabolic process is_a: GO:2001156 ! regulation of proline catabolic process to glutamate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010133 ! proline catabolic process to glutamate relationship: negatively_regulates GO:0010133 ! proline catabolic process to glutamate created_by: mcc creation_date: 2011-10-25T08:54:43Z [Term] id: GO:2001158 name: positive regulation of proline catabolic process to glutamate namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] synonym: "positive regulation of proline breakdown to glutamate" EXACT [GOC:obol] synonym: "positive regulation of proline degradation to glutamate" EXACT [GOC:obol] synonym: "positive regulation of proline oxidation" RELATED [GOC:obol] is_a: GO:0033243 ! positive regulation of cellular amine catabolic process is_a: GO:2000213 ! positive regulation of glutamate metabolic process is_a: GO:2000216 ! positive regulation of proline metabolic process is_a: GO:2001156 ! regulation of proline catabolic process to glutamate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010133 ! proline catabolic process to glutamate relationship: positively_regulates GO:0010133 ! proline catabolic process to glutamate created_by: mcc creation_date: 2011-10-25T08:54:50Z [Term] id: GO:2001159 name: regulation of protein localization by the Cvt pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway." [GOC:obol] synonym: "regulation of cytoplasm to vacuole targeting" EXACT [GOC:obol] synonym: "regulation of cytoplasm-to-vacuole targeting" EXACT [GOC:obol] is_a: GO:0050794 ! regulation of cellular process is_a: GO:1903335 ! regulation of vacuolar transport is_a: GO:1903533 ! regulation of protein targeting intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032258 ! cytoplasm to vacuole transport by the Cvt pathway relationship: regulates GO:0032258 ! cytoplasm to vacuole transport by the Cvt pathway created_by: jp creation_date: 2011-10-25T10:22:24Z [Term] id: GO:2001160 name: regulation of histone H3-K79 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] synonym: "regulation of histone H3 K79 methylation" EXACT [GOC:obol] synonym: "regulation of histone H3K79me" EXACT [GOC:obol] synonym: "regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034729 ! histone H3-K79 methylation relationship: regulates GO:0034729 ! histone H3-K79 methylation created_by: se creation_date: 2011-10-25T10:27:00Z [Term] id: GO:2001161 name: negative regulation of histone H3-K79 methylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] synonym: "negative regulation of histone H3 K79 methylation" EXACT [GOC:obol] synonym: "negative regulation of histone H3K79me" EXACT [GOC:obol] synonym: "negative regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] is_a: GO:0031061 ! negative regulation of histone methylation is_a: GO:2001160 ! regulation of histone H3-K79 methylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034729 ! histone H3-K79 methylation relationship: negatively_regulates GO:0034729 ! histone H3-K79 methylation created_by: se creation_date: 2011-10-25T10:27:05Z [Term] id: GO:2001162 name: positive regulation of histone H3-K79 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] synonym: "positive regulation of histone H3 K79 methylation" EXACT [GOC:obol] synonym: "positive regulation of histone H3K79me" EXACT [GOC:obol] synonym: "positive regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] is_a: GO:0031062 ! positive regulation of histone methylation is_a: GO:2001160 ! regulation of histone H3-K79 methylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0034729 ! histone H3-K79 methylation relationship: positively_regulates GO:0034729 ! histone H3-K79 methylation created_by: se creation_date: 2011-10-25T10:27:10Z [Term] id: GO:2001163 name: regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues relationship: regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues created_by: se creation_date: 2011-10-25T10:30:59Z [Term] id: GO:2001164 name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] is_a: GO:1901408 ! negative regulation of phosphorylation of RNA polymerase II C-terminal domain is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues relationship: negatively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues created_by: se creation_date: 2011-10-25T10:31:03Z [Term] id: GO:2001165 name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] is_a: GO:1901409 ! positive regulation of phosphorylation of RNA polymerase II C-terminal domain is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues relationship: positively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues created_by: se creation_date: 2011-10-25T10:31:07Z [Term] id: GO:2001166 name: regulation of histone H2B ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] is_a: GO:0033182 ! regulation of histone ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0033523 ! histone H2B ubiquitination relationship: regulates GO:0033523 ! histone H2B ubiquitination created_by: se creation_date: 2011-10-25T10:49:51Z [Term] id: GO:2001167 name: negative regulation of histone H2B ubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] is_a: GO:0033183 ! negative regulation of histone ubiquitination is_a: GO:2001166 ! regulation of histone H2B ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0033523 ! histone H2B ubiquitination relationship: negatively_regulates GO:0033523 ! histone H2B ubiquitination created_by: se creation_date: 2011-10-25T10:49:56Z [Term] id: GO:2001168 name: positive regulation of histone H2B ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] is_a: GO:0033184 ! positive regulation of histone ubiquitination is_a: GO:2001166 ! regulation of histone H2B ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0033523 ! histone H2B ubiquitination relationship: positively_regulates GO:0033523 ! histone H2B ubiquitination created_by: se creation_date: 2011-10-25T10:50:01Z [Term] id: GO:2001169 name: regulation of ATP biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "regulation of ATP anabolism" EXACT [GOC:obol] synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "regulation of ATP formation" EXACT [GOC:obol] synonym: "regulation of ATP regeneration" RELATED [GOC:obol] synonym: "regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006754 ! ATP biosynthetic process relationship: regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:03Z [Term] id: GO:2001170 name: negative regulation of ATP biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol] synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of ATP formation" EXACT [GOC:obol] synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol] synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process is_a: GO:1903579 ! negative regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006754 ! ATP biosynthetic process relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:13Z [Term] id: GO:2001171 name: positive regulation of ATP biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol] synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of ATP formation" EXACT [GOC:obol] synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol] synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol] is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process is_a: GO:1903580 ! positive regulation of ATP metabolic process is_a: GO:2001169 ! regulation of ATP biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006754 ! ATP biosynthetic process relationship: positively_regulates GO:0006754 ! ATP biosynthetic process created_by: kmv creation_date: 2011-10-26T03:18:26Z [Term] id: GO:2001172 name: positive regulation of glycolytic fermentation to ethanol namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] synonym: "positive regulation of ethanol fermentation" EXACT [GOC:obol] synonym: "positive regulation of glucose fermentation to ethanol" EXACT [GOC:obol] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:1903580 ! positive regulation of ATP metabolic process is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol relationship: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol created_by: mcc creation_date: 2011-10-27T02:39:09Z [Term] id: GO:2001173 name: regulation of histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] synonym: "regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] synonym: "regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] synonym: "regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] is_a: GO:2001166 ! regulation of histone H2B ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination relationship: regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination created_by: se creation_date: 2011-10-29T06:28:47Z [Term] id: GO:2001174 name: negative regulation of histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] synonym: "negative regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] synonym: "negative regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] synonym: "negative regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] is_a: GO:2001167 ! negative regulation of histone H2B ubiquitination is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination relationship: negatively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination created_by: se creation_date: 2011-10-29T06:28:53Z [Term] id: GO:2001175 name: positive regulation of histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] synonym: "positive regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] synonym: "positive regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] synonym: "positive regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] is_a: GO:2001168 ! positive regulation of histone H2B ubiquitination is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination relationship: positively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination created_by: se creation_date: 2011-10-29T06:28:59Z [Term] id: GO:2001176 name: regulation of mediator complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mediator complex assembly." [GOC:obol] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036034 ! mediator complex assembly relationship: regulates GO:0036034 ! mediator complex assembly created_by: yaf creation_date: 2011-11-02T11:22:18Z [Term] id: GO:2001177 name: negative regulation of mediator complex assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly." [GOC:obol] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:2001176 ! regulation of mediator complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036034 ! mediator complex assembly relationship: negatively_regulates GO:0036034 ! mediator complex assembly created_by: yaf creation_date: 2011-11-02T11:22:23Z [Term] id: GO:2001178 name: positive regulation of mediator complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mediator complex assembly." [GOC:obol] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:2001176 ! regulation of mediator complex assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036034 ! mediator complex assembly relationship: positively_regulates GO:0036034 ! mediator complex assembly created_by: yaf creation_date: 2011-11-02T11:22:27Z [Term] id: GO:2001179 name: regulation of interleukin-10 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] synonym: "regulation of IL-10 secretion" EXACT [GOC:obol] is_a: GO:0032653 ! regulation of interleukin-10 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072608 ! interleukin-10 secretion relationship: regulates GO:0072608 ! interleukin-10 secretion created_by: yaf creation_date: 2011-11-03T10:53:48Z [Term] id: GO:2001180 name: negative regulation of interleukin-10 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] synonym: "negative regulation of IL-10 secretion" EXACT [GOC:obol] is_a: GO:0032693 ! negative regulation of interleukin-10 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2001179 ! regulation of interleukin-10 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072608 ! interleukin-10 secretion relationship: negatively_regulates GO:0072608 ! interleukin-10 secretion created_by: yaf creation_date: 2011-11-03T10:53:54Z [Term] id: GO:2001181 name: positive regulation of interleukin-10 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] synonym: "positive regulation of IL-10 secretion" EXACT [GOC:obol] is_a: GO:0032733 ! positive regulation of interleukin-10 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2001179 ! regulation of interleukin-10 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072608 ! interleukin-10 secretion relationship: positively_regulates GO:0072608 ! interleukin-10 secretion created_by: yaf creation_date: 2011-11-03T10:53:58Z [Term] id: GO:2001182 name: regulation of interleukin-12 secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] synonym: "regulation of CLMF secretion" RELATED [GOC:obol] synonym: "regulation of IL-12 secretion" EXACT [GOC:obol] synonym: "regulation of IL12 secretion" EXACT [GOC:obol] synonym: "regulation of interleukin-12 complex secretion" EXACT [GOC:obol] synonym: "regulation of NKSF secretion" RELATED [GOC:obol] is_a: GO:0032655 ! regulation of interleukin-12 production is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072610 ! interleukin-12 secretion relationship: regulates GO:0072610 ! interleukin-12 secretion created_by: yaf creation_date: 2011-11-03T01:10:29Z [Term] id: GO:2001183 name: negative regulation of interleukin-12 secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] synonym: "negative regulation of CLMF secretion" RELATED [GOC:obol] synonym: "negative regulation of IL-12 secretion" EXACT [GOC:obol] synonym: "negative regulation of IL12 secretion" EXACT [GOC:obol] synonym: "negative regulation of interleukin-12 complex secretion" EXACT [GOC:obol] synonym: "negative regulation of NKSF secretion" RELATED [GOC:obol] is_a: GO:0032695 ! negative regulation of interleukin-12 production is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2001182 ! regulation of interleukin-12 secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072610 ! interleukin-12 secretion relationship: negatively_regulates GO:0072610 ! interleukin-12 secretion created_by: yaf creation_date: 2011-11-03T01:10:37Z [Term] id: GO:2001184 name: positive regulation of interleukin-12 secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] synonym: "positive regulation of CLMF secretion" RELATED [GOC:obol] synonym: "positive regulation of IL-12 secretion" EXACT [GOC:obol] synonym: "positive regulation of IL12 secretion" EXACT [GOC:obol] synonym: "positive regulation of interleukin-12 complex secretion" EXACT [GOC:obol] synonym: "positive regulation of NKSF secretion" RELATED [GOC:obol] is_a: GO:0032735 ! positive regulation of interleukin-12 production is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2001182 ! regulation of interleukin-12 secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072610 ! interleukin-12 secretion relationship: positively_regulates GO:0072610 ! interleukin-12 secretion created_by: yaf creation_date: 2011-11-03T01:10:41Z [Term] id: GO:2001185 name: regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046634 ! regulation of alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation relationship: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation created_by: yaf creation_date: 2011-11-03T01:16:51Z [Term] id: GO:2001186 name: negative regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation relationship: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation created_by: yaf creation_date: 2011-11-03T01:16:57Z [Term] id: GO:2001187 name: positive regulation of CD8-positive, alpha-beta T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation relationship: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation created_by: yaf creation_date: 2011-11-03T01:17:02Z [Term] id: GO:2001188 name: regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] synonym: "regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0050776 ! regulation of immune response is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell relationship: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell created_by: yaf creation_date: 2011-11-03T01:31:30Z [Term] id: GO:2001189 name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] synonym: "negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0050777 ! negative regulation of immune response is_a: GO:0050868 ! negative regulation of T cell activation is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell relationship: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell created_by: yaf creation_date: 2011-11-03T01:31:36Z [Term] id: GO:2001190 name: positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] synonym: "positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0050778 ! positive regulation of immune response is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell relationship: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell created_by: yaf creation_date: 2011-11-03T01:31:40Z [Term] id: GO:2001191 name: regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0046643 ! regulation of gamma-delta T cell activation is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response relationship: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response created_by: yaf creation_date: 2011-11-03T04:28:38Z [Term] id: GO:2001192 name: negative regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "negative regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "negative regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation is_a: GO:0050777 ! negative regulation of immune response is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response relationship: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response created_by: yaf creation_date: 2011-11-03T04:28:44Z [Term] id: GO:2001193 name: positive regulation of gamma-delta T cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] synonym: "positive regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] synonym: "positive regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation is_a: GO:0050778 ! positive regulation of immune response is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response relationship: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response created_by: yaf creation_date: 2011-11-03T04:28:48Z [Term] id: GO:2001194 name: regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] synonym: "regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] synonym: "regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine relationship: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine created_by: mcc creation_date: 2011-11-03T07:57:11Z [Term] id: GO:2001195 name: negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] synonym: "negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] synonym: "negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] is_a: GO:1902987 ! negative regulation of lysine biosynthetic process via aminoadipic acid is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine relationship: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine created_by: mcc creation_date: 2011-11-03T07:57:18Z [Term] id: GO:2001196 name: positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] synonym: "positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] synonym: "positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine relationship: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine created_by: mcc creation_date: 2011-11-03T07:57:24Z [Term] id: GO:2001197 name: basement membrane assembly involved in embryonic body morphogenesis namespace: biological_process def: "Any basement membrane assembly that is involved in embryonic body morphogenesis." [GOC:obol] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0070831 ! basement membrane assembly intersection_of: GO:0070831 ! basement membrane assembly intersection_of: part_of GO:0010172 ! embryonic body morphogenesis relationship: part_of GO:0010172 ! embryonic body morphogenesis created_by: kmv creation_date: 2011-11-03T08:44:33Z [Term] id: GO:2001198 name: regulation of dendritic cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097028 ! dendritic cell differentiation relationship: regulates GO:0097028 ! dendritic cell differentiation created_by: yaf creation_date: 2011-11-04T02:01:27Z [Term] id: GO:2001199 name: negative regulation of dendritic cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902106 ! negative regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097028 ! dendritic cell differentiation relationship: negatively_regulates GO:0097028 ! dendritic cell differentiation created_by: yaf creation_date: 2011-11-04T02:01:33Z [Term] id: GO:2001200 name: positive regulation of dendritic cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902107 ! positive regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097028 ! dendritic cell differentiation relationship: positively_regulates GO:0097028 ! dendritic cell differentiation created_by: yaf creation_date: 2011-11-04T02:01:36Z [Term] id: GO:2001201 name: regulation of transforming growth factor-beta secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol] synonym: "regulation of TGF-beta secretion" EXACT [GOC:obol] synonym: "regulation of TGFbeta secretion" EXACT [GOC:obol] is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038044 ! transforming growth factor-beta secretion relationship: regulates GO:0038044 ! transforming growth factor-beta secretion created_by: yaf creation_date: 2011-11-10T04:29:46Z [Term] id: GO:2001202 name: negative regulation of transforming growth factor-beta secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol] synonym: "negative regulation of TGF-beta secretion" EXACT [GOC:obol] synonym: "negative regulation of TGFbeta secretion" EXACT [GOC:obol] is_a: GO:0050710 ! negative regulation of cytokine secretion is_a: GO:2001201 ! regulation of transforming growth factor-beta secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038044 ! transforming growth factor-beta secretion relationship: negatively_regulates GO:0038044 ! transforming growth factor-beta secretion created_by: yaf creation_date: 2011-11-10T04:29:52Z [Term] id: GO:2001203 name: positive regulation of transforming growth factor-beta secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor-beta secretion." [GOC:obol] synonym: "positive regulation of TGF-beta secretion" EXACT [GOC:obol] synonym: "positive regulation of TGFbeta secretion" EXACT [GOC:obol] is_a: GO:0050715 ! positive regulation of cytokine secretion is_a: GO:2001201 ! regulation of transforming growth factor-beta secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0038044 ! transforming growth factor-beta secretion relationship: positively_regulates GO:0038044 ! transforming growth factor-beta secretion created_by: yaf creation_date: 2011-11-10T04:29:57Z [Term] id: GO:2001204 name: regulation of osteoclast development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0045670 ! regulation of osteoclast differentiation is_a: GO:0060284 ! regulation of cell development is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036035 ! osteoclast development relationship: regulates GO:0036035 ! osteoclast development created_by: yaf creation_date: 2011-11-10T10:58:59Z [Term] id: GO:2001205 name: negative regulation of osteoclast development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045671 ! negative regulation of osteoclast differentiation is_a: GO:1903011 ! negative regulation of bone development is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036035 ! osteoclast development relationship: negatively_regulates GO:0036035 ! osteoclast development created_by: yaf creation_date: 2011-11-10T10:59:06Z [Term] id: GO:2001206 name: positive regulation of osteoclast development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0045672 ! positive regulation of osteoclast differentiation is_a: GO:1903012 ! positive regulation of bone development is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036035 ! osteoclast development relationship: positively_regulates GO:0036035 ! osteoclast development created_by: yaf creation_date: 2011-11-10T10:59:12Z [Term] id: GO:2001207 name: regulation of transcription elongation from RNA polymerase I promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458] synonym: "regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter created_by: se creation_date: 2011-11-11T10:46:28Z [Term] id: GO:2001208 name: negative regulation of transcription elongation by RNA polymerase I namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I." [PMID:20299458] synonym: "negative regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] synonym: "negative regulation of transcription elongation from RNA polymerase I promoter" EXACT [] is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: negatively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter created_by: se creation_date: 2011-11-11T10:46:36Z [Term] id: GO:2001209 name: positive regulation of transcription elongation from RNA polymerase I promoter namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458] synonym: "positive regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: positively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter created_by: se creation_date: 2011-11-11T10:46:41Z [Term] id: GO:2001210 name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al] synonym: "regulation of Ac-MVA pathway" EXACT [GOC:obol] synonym: "regulation of acetate-mevalonate pathway" EXACT [GOC:obol] synonym: "regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol] synonym: "regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol] synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway relationship: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway created_by: rfoulger creation_date: 2011-11-15T10:53:42Z [Term] id: GO:2001211 name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al] synonym: "negative regulation of Ac-MVA pathway" EXACT [GOC:obol] synonym: "negative regulation of acetate-mevalonate pathway" EXACT [GOC:obol] synonym: "negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol] synonym: "negative regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol] synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol] is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway relationship: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway created_by: rfoulger creation_date: 2011-11-15T10:53:45Z [Term] id: GO:2001212 name: regulation of vasculogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001570 ! vasculogenesis relationship: regulates GO:0001570 ! vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:31Z [Term] id: GO:2001213 name: negative regulation of vasculogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001570 ! vasculogenesis relationship: negatively_regulates GO:0001570 ! vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:36Z [Term] id: GO:2001214 name: positive regulation of vasculogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1904018 ! positive regulation of vasculature development is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001570 ! vasculogenesis relationship: positively_regulates GO:0001570 ! vasculogenesis created_by: yaf creation_date: 2011-11-15T01:22:39Z [Term] id: GO:2001215 name: regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al] synonym: "regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol] synonym: "regulation of HMG-CoA reductase activity" RELATED [GOC:obol] is_a: GO:0051341 ! regulation of oxidoreductase activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity relationship: regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity created_by: rfoulger creation_date: 2011-11-16T11:34:11Z [Term] id: GO:2001216 name: negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al] synonym: "negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol] synonym: "negative regulation of HMG-CoA reductase activity" RELATED [GOC:obol] is_a: GO:0051354 ! negative regulation of oxidoreductase activity is_a: GO:2001215 ! regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity relationship: negatively_regulates GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity created_by: rfoulger creation_date: 2011-11-16T11:34:17Z [Term] id: GO:2001217 name: obsolete regulation of S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "regulation of S/G2 transition of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0044770 created_by: dph creation_date: 2011-11-16T09:14:42Z [Term] id: GO:2001218 name: obsolete negative regulation of S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "negative regulation of S/G2 transition of mitotic cell cycle" EXACT [] is_obsolete: true created_by: dph creation_date: 2011-11-16T09:14:47Z [Term] id: GO:2001219 name: obsolete positive regulation of S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "positive regulation of S/G2 transition of mitotic cell cycle" EXACT [] is_obsolete: true created_by: dph creation_date: 2011-11-16T09:14:50Z [Term] id: GO:2001220 name: obsolete negative regulation of G2 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "negative regulation of G2 phase of mitotic cell cycle" EXACT [] is_obsolete: true created_by: yaf creation_date: 2011-11-17T03:28:44Z [Term] id: GO:2001221 name: obsolete positive regulation of G2 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "positive regulation of G2 phase of mitotic cell cycle" EXACT [] is_obsolete: true created_by: yaf creation_date: 2011-11-17T03:28:48Z [Term] id: GO:2001222 name: regulation of neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "regulation of neuron guidance" RELATED [GOC:obol] synonym: "regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001764 ! neuron migration relationship: regulates GO:0001764 ! neuron migration created_by: kmv creation_date: 2011-11-17T10:01:38Z [Term] id: GO:2001223 name: negative regulation of neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "negative regulation of neuron guidance" RELATED [GOC:obol] synonym: "negative regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001764 ! neuron migration relationship: negatively_regulates GO:0001764 ! neuron migration created_by: kmv creation_date: 2011-11-17T10:01:45Z [Term] id: GO:2001224 name: positive regulation of neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "positive regulation of neuron guidance" RELATED [GOC:obol] synonym: "positive regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001764 ! neuron migration relationship: positively_regulates GO:0001764 ! neuron migration created_by: kmv creation_date: 2011-11-17T10:01:49Z [Term] id: GO:2001225 name: regulation of chloride transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chloride transport." [GOC:dph] is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006821 ! chloride transport relationship: regulates GO:0006821 ! chloride transport created_by: dph creation_date: 2011-11-18T05:45:56Z [Term] id: GO:2001226 name: negative regulation of chloride transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport." [GOC:dph] is_a: GO:1903792 ! negative regulation of anion transport is_a: GO:2001225 ! regulation of chloride transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006821 ! chloride transport relationship: negatively_regulates GO:0006821 ! chloride transport created_by: dph creation_date: 2011-11-18T05:46:03Z [Term] id: GO:2001227 name: quercitrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with quercitrin." [GOC:obol] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0097243 ! flavonoid binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: tanyaberardini creation_date: 2011-11-18T09:58:37Z [Term] id: GO:2001228 name: regulation of response to gamma radiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "regulation of response to gamma ray" RELATED [GOC:obol] synonym: "regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0010332 ! response to gamma radiation relationship: regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:07Z [Term] id: GO:2001229 name: negative regulation of response to gamma radiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "negative regulation of response to gamma ray" RELATED [GOC:obol] synonym: "negative regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0010332 ! response to gamma radiation relationship: negatively_regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:14Z [Term] id: GO:2001230 name: positive regulation of response to gamma radiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to gamma radiation." [GOC:obol] synonym: "positive regulation of response to gamma ray" RELATED [GOC:obol] synonym: "positive regulation of response to gamma-ray photon" RELATED [GOC:obol] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:2001228 ! regulation of response to gamma radiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0010332 ! response to gamma radiation relationship: positively_regulates GO:0010332 ! response to gamma radiation created_by: yaf creation_date: 2011-11-20T04:51:17Z [Term] id: GO:2001231 name: regulation of protein localization to prospore membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah] synonym: "regulation of protein localisation to prospore membrane" EXACT [] synonym: "regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol] synonym: "regulation of protein targeting to forespore membrane" RELATED [GOC:obol] synonym: "regulation of protein targeting to FSM" RELATED [GOC:obol] synonym: "regulation of protein targeting to prospore membrane" RELATED [] synonym: "regulation of protein-prospore membrane targeting" RELATED [GOC:obol] is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902657 ! protein localization to prospore membrane relationship: regulates GO:1902657 ! protein localization to prospore membrane created_by: midori creation_date: 2011-11-21T04:13:30Z [Term] id: GO:2001232 name: positive regulation of protein localization to prospore membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah] synonym: "positive regulation of protein localisation to prospore membrane" EXACT [] synonym: "positive regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol] synonym: "positive regulation of protein targeting to forespore membrane" RELATED [GOC:obol] synonym: "positive regulation of protein targeting to FSM" RELATED [GOC:obol] synonym: "positive regulation of protein targeting to prospore membrane" RELATED [] synonym: "positive regulation of protein-prospore membrane targeting" RELATED [GOC:obol] is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane is_a: GO:2001231 ! regulation of protein localization to prospore membrane intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902657 ! protein localization to prospore membrane relationship: positively_regulates GO:1902657 ! protein localization to prospore membrane created_by: midori creation_date: 2011-11-21T04:13:36Z [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097190 ! apoptotic signaling pathway relationship: regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:49Z [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097190 ! apoptotic signaling pathway relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:54Z [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097190 ! apoptotic signaling pathway relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:20:58Z [Term] id: GO:2001236 name: regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of extrinsic apoptosis" NARROW [] synonym: "regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097191 ! extrinsic apoptotic signaling pathway relationship: regulates GO:0097191 ! extrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:30:05Z [Term] id: GO:2001237 name: negative regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of extrinsic apoptosis" NARROW [] synonym: "negative regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway relationship: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:30:11Z [Term] id: GO:2001238 name: positive regulation of extrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of extrinsic apoptosis" NARROW [] synonym: "positive regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway relationship: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:30:16Z [Term] id: GO:2001239 name: regulation of extrinsic apoptotic signaling pathway in absence of ligand namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] synonym: "regulation of dependence receptor signaling pathway" RELATED [GOC:obol] synonym: "regulation of extrinsic apoptosis in absence of ligand" NARROW [] synonym: "regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand relationship: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand created_by: pr creation_date: 2011-11-24T01:33:18Z [Term] id: GO:2001240 name: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] synonym: "negative regulation of dependence receptor signaling pathway" RELATED [GOC:obol] synonym: "negative regulation of extrinsic apoptosis in absence of ligand" NARROW [] synonym: "negative regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] is_a: GO:1901099 ! negative regulation of signal transduction in absence of ligand is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand relationship: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand created_by: pr creation_date: 2011-11-24T01:33:25Z [Term] id: GO:2001241 name: positive regulation of extrinsic apoptotic signaling pathway in absence of ligand namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] synonym: "positive regulation of dependence receptor signaling pathway" RELATED [GOC:obol] synonym: "positive regulation of extrinsic apoptosis in absence of ligand" NARROW [] synonym: "positive regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand relationship: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand created_by: pr creation_date: 2011-11-24T01:33:31Z [Term] id: GO:2001242 name: regulation of intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of intrinsic apoptosis" NARROW [] synonym: "regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] synonym: "regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] synonym: "regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] is_a: GO:1902531 ! regulation of intracellular signal transduction is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097193 ! intrinsic apoptotic signaling pathway relationship: regulates GO:0097193 ! intrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:35:56Z [Term] id: GO:2001243 name: negative regulation of intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of intrinsic apoptosis" NARROW [] synonym: "negative regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] synonym: "negative regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] is_a: GO:1902532 ! negative regulation of intracellular signal transduction is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway relationship: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:36:03Z [Term] id: GO:2001244 name: positive regulation of intrinsic apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of intrinsic apoptosis" NARROW [] synonym: "positive regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] synonym: "positive regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] is_a: GO:1902533 ! positive regulation of intracellular signal transduction is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway relationship: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway created_by: pr creation_date: 2011-11-24T01:36:07Z [Term] id: GO:2001245 name: regulation of phosphatidylcholine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] synonym: "regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] synonym: "regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] synonym: "regulation of phosphatidylcholine formation" EXACT [GOC:obol] synonym: "regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006656 ! phosphatidylcholine biosynthetic process relationship: regulates GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2011-11-28T09:47:32Z [Term] id: GO:2001246 name: negative regulation of phosphatidylcholine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] synonym: "negative regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] synonym: "negative regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of phosphatidylcholine formation" EXACT [GOC:obol] synonym: "negative regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2011-11-28T09:47:47Z [Term] id: GO:2001247 name: positive regulation of phosphatidylcholine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] synonym: "positive regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] synonym: "positive regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of phosphatidylcholine formation" EXACT [GOC:obol] synonym: "positive regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process created_by: tanyaberardini creation_date: 2011-11-28T09:47:54Z [Term] id: GO:2001248 name: regulation of ammonia assimilation cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] synonym: "regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] synonym: "regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] is_a: GO:0006808 ! regulation of nitrogen utilization is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019676 ! ammonia assimilation cycle relationship: regulates GO:0019676 ! ammonia assimilation cycle created_by: rl creation_date: 2011-12-01T10:08:21Z [Term] id: GO:2001249 name: negative regulation of ammonia assimilation cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] synonym: "negative regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] synonym: "negative regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] is_a: GO:0045847 ! negative regulation of nitrogen utilization is_a: GO:2000212 ! negative regulation of glutamate metabolic process is_a: GO:2001248 ! regulation of ammonia assimilation cycle intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019676 ! ammonia assimilation cycle relationship: negatively_regulates GO:0019676 ! ammonia assimilation cycle created_by: rl creation_date: 2011-12-01T10:08:29Z [Term] id: GO:2001250 name: positive regulation of ammonia assimilation cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] synonym: "positive regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] synonym: "positive regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] is_a: GO:0045848 ! positive regulation of nitrogen utilization is_a: GO:2000213 ! positive regulation of glutamate metabolic process is_a: GO:2001248 ! regulation of ammonia assimilation cycle intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019676 ! ammonia assimilation cycle relationship: positively_regulates GO:0019676 ! ammonia assimilation cycle created_by: rl creation_date: 2011-12-01T10:08:34Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051276 ! chromosome organization relationship: negatively_regulates GO:0051276 ! chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051276 ! chromosome organization relationship: positively_regulates GO:0051276 ! chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:26Z [Term] id: GO:2001253 name: regulation of histone H3-K36 trimethylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] is_a: GO:0000414 ! regulation of histone H3-K36 methylation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097198 ! histone H3-K36 trimethylation relationship: regulates GO:0097198 ! histone H3-K36 trimethylation created_by: pr creation_date: 2011-12-06T07:38:09Z [Term] id: GO:2001254 name: negative regulation of histone H3-K36 trimethylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] is_a: GO:0000415 ! negative regulation of histone H3-K36 methylation is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097198 ! histone H3-K36 trimethylation relationship: negatively_regulates GO:0097198 ! histone H3-K36 trimethylation created_by: pr creation_date: 2011-12-06T07:38:17Z [Term] id: GO:2001255 name: positive regulation of histone H3-K36 trimethylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] is_a: GO:0000416 ! positive regulation of histone H3-K36 methylation is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097198 ! histone H3-K36 trimethylation relationship: positively_regulates GO:0097198 ! histone H3-K36 trimethylation created_by: pr creation_date: 2011-12-06T07:38:24Z [Term] id: GO:2001256 name: regulation of store-operated calcium entry namespace: biological_process def: "Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF] synonym: "regulation of calcium ion import" RELATED [GOC:obol] synonym: "regulation of capacitative calcium entry" EXACT [GOC:obol] synonym: "regulation of SOCE" EXACT [GOC:obol] synonym: "regulation of store-operated calcium import" EXACT [GOC:obol] is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002115 ! store-operated calcium entry relationship: regulates GO:0002115 ! store-operated calcium entry created_by: vk creation_date: 2011-12-07T07:08:38Z [Term] id: GO:2001257 name: regulation of cation channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cation channel activity." [GOC:BHF] synonym: "regulation of cation diffusion facilitator activity" EXACT [GOC:obol] synonym: "regulation of nonselective cation channel activity" EXACT [GOC:obol] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1904062 ! regulation of cation transmembrane transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005261 ! cation channel activity relationship: regulates GO:0005261 ! cation channel activity created_by: vk creation_date: 2011-12-07T07:14:43Z [Term] id: GO:2001258 name: negative regulation of cation channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF] synonym: "negative regulation of cation diffusion facilitator activity" EXACT [GOC:obol] synonym: "negative regulation of nonselective cation channel activity" EXACT [GOC:obol] is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005261 ! cation channel activity relationship: negatively_regulates GO:0005261 ! cation channel activity created_by: vk creation_date: 2011-12-07T07:14:51Z [Term] id: GO:2001259 name: positive regulation of cation channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF] synonym: "positive regulation of cation diffusion facilitator activity" EXACT [GOC:obol] synonym: "positive regulation of nonselective cation channel activity" EXACT [GOC:obol] is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005261 ! cation channel activity relationship: positively_regulates GO:0005261 ! cation channel activity created_by: vk creation_date: 2011-12-07T07:14:57Z [Term] id: GO:2001260 name: regulation of semaphorin-plexin signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] synonym: "regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071526 ! semaphorin-plexin signaling pathway relationship: regulates GO:0071526 ! semaphorin-plexin signaling pathway created_by: vk creation_date: 2011-12-08T02:05:41Z [Term] id: GO:2001261 name: negative regulation of semaphorin-plexin signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] synonym: "negative regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway relationship: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway created_by: vk creation_date: 2011-12-08T02:05:48Z [Term] id: GO:2001262 name: positive regulation of semaphorin-plexin signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] synonym: "positive regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway relationship: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway created_by: vk creation_date: 2011-12-08T02:05:53Z [Term] id: GO:2001263 name: regulation of C-C chemokine binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of C-C chemokine binding." [GOC:obol] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019957 ! C-C chemokine binding relationship: regulates GO:0019957 ! C-C chemokine binding created_by: yaf creation_date: 2011-12-09T01:13:54Z [Term] id: GO:2001264 name: negative regulation of C-C chemokine binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding." [GOC:obol] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:2001263 ! regulation of C-C chemokine binding intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019957 ! C-C chemokine binding relationship: negatively_regulates GO:0019957 ! C-C chemokine binding created_by: yaf creation_date: 2011-12-09T01:14:01Z [Term] id: GO:2001265 name: positive regulation of C-C chemokine binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding." [GOC:obol] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:2001263 ! regulation of C-C chemokine binding intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0019957 ! C-C chemokine binding relationship: positively_regulates GO:0019957 ! C-C chemokine binding created_by: yaf creation_date: 2011-12-09T01:14:07Z [Term] id: GO:2001266 name: Roundabout signaling pathway involved in axon guidance namespace: biological_process def: "Any Roundabout signaling pathway that is involved in axon guidance." [GOC:bf, PMID:14527427, PMID:21820427] synonym: "ROBO signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] synonym: "ROBO signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] synonym: "ROBO signaling pathway involved in axon guidance" EXACT [GOC:obol] synonym: "ROBO signaling pathway involved in axon pathfinding" EXACT [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in axon guidance" EXACT [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in axon pathfinding" EXACT [GOC:obol] synonym: "Roundabout signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] synonym: "Roundabout signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] synonym: "Roundabout signaling pathway involved in axon pathfinding" EXACT [GOC:obol] synonym: "Roundabout signalling pathway involved in axon chemotaxis" RELATED [GOC:obol] synonym: "Roundabout signalling pathway involved in axon growth cone guidance" RELATED [GOC:obol] synonym: "Roundabout signalling pathway involved in axon guidance" EXACT [GOC:obol] synonym: "Roundabout signalling pathway involved in axon pathfinding" EXACT [GOC:obol] is_a: GO:0035385 ! Roundabout signaling pathway intersection_of: GO:0035385 ! Roundabout signaling pathway intersection_of: part_of GO:0007411 ! axon guidance relationship: part_of GO:0007411 ! axon guidance created_by: rfoulger creation_date: 2011-12-12T03:40:20Z [Term] id: GO:2001267 name: regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] synonym: "regulation of initiator caspase activity" NARROW [GOC:obol] is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway relationship: regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway created_by: pr creation_date: 2011-12-13T07:56:13Z [Term] id: GO:2001268 name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of initiator caspase activity" NARROW [GOC:obol] is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway relationship: negatively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway created_by: pr creation_date: 2011-12-13T07:56:21Z [Term] id: GO:2001269 name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of initiator caspase activity" NARROW [GOC:obol] is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway relationship: positively_regulates GO:0097199 ! cysteine-type endopeptidase activity involved in apoptotic signaling pathway created_by: pr creation_date: 2011-12-13T07:56:26Z [Term] id: GO:2001270 name: regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] synonym: "regulation of effector caspase activity" NARROW [GOC:obol] is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis relationship: regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis created_by: pr creation_date: 2011-12-13T07:59:36Z [Term] id: GO:2001271 name: negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] synonym: "negative regulation of effector caspase activity" NARROW [GOC:obol] is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:1900118 ! negative regulation of execution phase of apoptosis is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis relationship: negatively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis created_by: pr creation_date: 2011-12-13T07:59:42Z [Term] id: GO:2001272 name: positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] synonym: "positive regulation of effector caspase activity" NARROW [GOC:obol] is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process is_a: GO:1900119 ! positive regulation of execution phase of apoptosis is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis relationship: positively_regulates GO:0097200 ! cysteine-type endopeptidase activity involved in execution phase of apoptosis created_by: pr creation_date: 2011-12-13T07:59:47Z [Term] id: GO:2001273 name: obsolete regulation of glucose import in response to insulin stimulus namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] comment: This term was obsoleted because it represents a GO-CAM model, seehttps://github.com/geneontology/go-ontology/issues/15961. synonym: "regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] is_obsolete: true created_by: vk creation_date: 2011-12-13T12:29:31Z [Term] id: GO:2001274 name: obsolete negative regulation of glucose import in response to insulin stimulus namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] comment: This term was obsoleted because it represents a GO-CAM model, seehttps://github.com/geneontology/go-ontology/issues/15961. synonym: "negative regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] is_obsolete: true created_by: vk creation_date: 2011-12-13T12:29:38Z [Term] id: GO:2001275 name: obsolete positive regulation of glucose import in response to insulin stimulus namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] comment: This term was obsoleted because it represents a GO-CAM model, seehttps://github.com/geneontology/go-ontology/issues/15961. synonym: "positive regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] is_obsolete: true created_by: vk creation_date: 2011-12-13T12:29:43Z [Term] id: GO:2001276 name: regulation of leucine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] synonym: "regulation of leucine anabolism" EXACT [GOC:obol] synonym: "regulation of leucine biosynthesis" EXACT [GOC:obol] synonym: "regulation of leucine formation" EXACT [GOC:obol] synonym: "regulation of leucine synthesis" EXACT [GOC:obol] is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009098 ! leucine biosynthetic process relationship: regulates GO:0009098 ! leucine biosynthetic process created_by: mcc creation_date: 2011-12-13T03:13:27Z [Term] id: GO:2001277 name: negative regulation of leucine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] synonym: "negative regulation of leucine anabolism" EXACT [GOC:obol] synonym: "negative regulation of leucine biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of leucine formation" EXACT [GOC:obol] synonym: "negative regulation of leucine synthesis" EXACT [GOC:obol] is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process is_a: GO:2001276 ! regulation of leucine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009098 ! leucine biosynthetic process relationship: negatively_regulates GO:0009098 ! leucine biosynthetic process created_by: mcc creation_date: 2011-12-13T03:13:36Z [Term] id: GO:2001278 name: positive regulation of leucine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] synonym: "positive regulation of leucine anabolism" EXACT [GOC:obol] synonym: "positive regulation of leucine biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of leucine formation" EXACT [GOC:obol] synonym: "positive regulation of leucine synthesis" EXACT [GOC:obol] is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process is_a: GO:2001276 ! regulation of leucine biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009098 ! leucine biosynthetic process relationship: positively_regulates GO:0009098 ! leucine biosynthetic process created_by: mcc creation_date: 2011-12-13T03:13:42Z [Term] id: GO:2001279 name: regulation of unsaturated fatty acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636] synonym: "regulation of fatty acid desaturation" RELATED [GOC:obol] synonym: "regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol] synonym: "regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol] synonym: "regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of unsaturated fatty acid formation" EXACT [GOC:obol] synonym: "regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process relationship: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process created_by: dgf creation_date: 2011-12-14T07:48:26Z [Term] id: GO:2001280 name: positive regulation of unsaturated fatty acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636] synonym: "positive regulation of fatty acid desaturation" RELATED [GOC:obol] synonym: "positive regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol] synonym: "positive regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of unsaturated fatty acid formation" EXACT [GOC:obol] synonym: "positive regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol] is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process relationship: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process created_by: dgf creation_date: 2011-12-14T07:48:33Z [Term] id: GO:2001281 name: regulation of muscle cell chemotaxis toward tendon cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell." [GOC:sart] synonym: "regulation of muscle cell attraction" RELATED [GOC:obol] synonym: "regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell relationship: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell created_by: rfoulger creation_date: 2011-12-15T10:39:36Z [Term] id: GO:2001282 name: negative regulation of muscle cell chemotaxis toward tendon cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells." [GOC:sart, PMID:19793885, PMID:20404543] synonym: "arrest of muscle cell chemotaxis" NARROW [GOC:bf, GOC:sart, PMID:19793885] synonym: "negative regulation of muscle cell attraction" RELATED [GOC:obol] synonym: "negative regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001281 ! regulation of muscle cell chemotaxis toward tendon cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell relationship: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell created_by: rfoulger creation_date: 2011-12-15T10:39:42Z [Term] id: GO:2001283 name: Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell namespace: biological_process def: "Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus." [GOC:bf, GOC:obol, GOC:sart, PMID:19793885] synonym: "ROBO signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] synonym: "ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] synonym: "ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] synonym: "Roundabout signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] synonym: "Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] synonym: "Roundabout signalling pathway involved in muscle cell attraction" RELATED [GOC:obol] synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] is_a: GO:0035385 ! Roundabout signaling pathway intersection_of: GO:0035385 ! Roundabout signaling pathway intersection_of: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell relationship: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell created_by: rfoulger creation_date: 2011-12-15T10:42:03Z [Term] id: GO:2001284 name: regulation of BMP secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of BMP secretion." [GOC:sart] synonym: "regulation of BMP protein secretion" EXACT [GOC:obol] synonym: "regulation of bone morphogenetic protein secretion" EXACT [GOC:obol] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0050708 ! regulation of protein secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0038055 ! BMP secretion relationship: regulates GO:0038055 ! BMP secretion created_by: rfoulger creation_date: 2011-12-15T02:15:28Z [Term] id: GO:2001285 name: negative regulation of BMP secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion." [GOC:sart] synonym: "negative regulation of BMP protein secretion" EXACT [GOC:obol] synonym: "negative regulation of bone morphogenetic protein secretion" EXACT [GOC:obol] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:2001284 ! regulation of BMP secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0038055 ! BMP secretion relationship: negatively_regulates GO:0038055 ! BMP secretion created_by: rfoulger creation_date: 2011-12-15T02:15:36Z [Term] id: GO:2001286 name: regulation of caveolin-mediated endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] synonym: "regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] synonym: "regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] synonym: "regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] is_a: GO:0030100 ! regulation of endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0072584 ! caveolin-mediated endocytosis relationship: regulates GO:0072584 ! caveolin-mediated endocytosis created_by: yaf creation_date: 2011-12-15T04:13:19Z [Term] id: GO:2001287 name: negative regulation of caveolin-mediated endocytosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] synonym: "negative regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] synonym: "negative regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] synonym: "negative regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis relationship: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis created_by: yaf creation_date: 2011-12-15T04:13:27Z [Term] id: GO:2001288 name: positive regulation of caveolin-mediated endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] synonym: "positive regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] synonym: "positive regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] synonym: "positive regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0072584 ! caveolin-mediated endocytosis relationship: positively_regulates GO:0072584 ! caveolin-mediated endocytosis created_by: yaf creation_date: 2011-12-15T04:13:32Z [Term] id: GO:2001289 name: lipid X metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate." [GOC:obol] synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol] synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol] synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol] synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol] synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process" EXACT [GOC:obol] synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism" EXACT [GOC:obol] synonym: "Lipid X metabolic process" EXACT [GOC:obol] synonym: "Lipid X metabolism" EXACT [GOC:obol] synonym: "lipid X metabolism" EXACT [GOC:obol] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process created_by: tanyaberardini creation_date: 2012-01-13T11:28:58Z [Term] id: GO:2001290 name: hydroperoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hydroperoxide." [CHEBI:35923, GOC:rs, PMID:15917183, PMID:18084891] synonym: "hydroperoxide metabolism" EXACT [GOC:obol] is_a: GO:0044237 ! cellular metabolic process created_by: pr creation_date: 2012-02-09T03:35:37Z [Term] id: GO:2001291 name: codeine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [CHEBI:16714, GOC:yaf] synonym: "codeine metabolism" EXACT [GOC:obol] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: pr creation_date: 2012-02-14T01:10:03Z [Term] id: GO:2001292 name: codeine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [CHEBI:16714, GOC:yaf, UniPathway:UPA00318] synonym: "codeine breakdown" EXACT [GOC:obol] synonym: "codeine catabolism" EXACT [GOC:obol] synonym: "codeine degradation" EXACT [GOC:obol] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process is_a: GO:2001291 ! codeine metabolic process created_by: pr creation_date: 2012-02-14T01:10:09Z [Term] id: GO:2001293 name: malonyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598] synonym: "malonyl-CoA metabolism" EXACT [GOC:obol] is_a: GO:0006637 ! acyl-CoA metabolic process created_by: pr creation_date: 2012-02-14T02:23:11Z [Term] id: GO:2001294 name: malonyl-CoA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf] synonym: "malonyl-CoA breakdown" EXACT [GOC:obol] synonym: "malonyl-CoA catabolism" EXACT [GOC:obol] synonym: "malonyl-CoA degradation" EXACT [GOC:obol] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:2001293 ! malonyl-CoA metabolic process created_by: pr creation_date: 2012-02-14T02:23:17Z [Term] id: GO:2001295 name: malonyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A." [CHEBI:15531, GOC:yaf, UniPathway:UPA00655] synonym: "malonyl-CoA anabolism" EXACT [GOC:obol] synonym: "malonyl-CoA biosynthesis" EXACT [GOC:obol] synonym: "malonyl-CoA formation" EXACT [GOC:obol] synonym: "malonyl-CoA synthesis" EXACT [GOC:obol] is_a: GO:0071616 ! acyl-CoA biosynthetic process is_a: GO:2001293 ! malonyl-CoA metabolic process created_by: pr creation_date: 2012-02-14T02:23:21Z [Term] id: GO:2001296 name: N(omega)-methyl-L-arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N(omega)-methyl-L-arginine." [CHEBI:28229, GOC:rs, PMID:10510241] synonym: "N(omega)-methyl-L-arginine metabolism" EXACT [GOC:obol] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: pr creation_date: 2012-02-14T03:38:16Z [Term] id: GO:2001297 name: N(omega)-methyl-L-arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine." [CHEBI:28229, GOC:rs, PMID:10510241] synonym: "N(omega)-methyl-L-arginine breakdown" EXACT [GOC:obol] synonym: "N(omega)-methyl-L-arginine catabolism" EXACT [GOC:obol] synonym: "N(omega)-methyl-L-arginine degradation" EXACT [GOC:obol] is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process is_a: GO:2001296 ! N(omega)-methyl-L-arginine metabolic process created_by: pr creation_date: 2012-02-14T03:38:21Z [Term] id: GO:2001298 name: N(omega),N(omega)-dimethyl-L-arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [CHEBI:17929, GOC:rs, PMID:10510241] synonym: "N(omega),N(omega)-dimethyl-L-arginine metabolism" EXACT [GOC:obol] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: pr creation_date: 2012-02-14T03:39:59Z [Term] id: GO:2001299 name: N(omega),N(omega)-dimethyl-L-arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [CHEBI:17929, GOC:rs, PMID:10510241] synonym: "N(omega),N(omega)-dimethyl-L-arginine breakdown" EXACT [GOC:obol] synonym: "N(omega),N(omega)-dimethyl-L-arginine catabolism" EXACT [GOC:obol] synonym: "N(omega),N(omega)-dimethyl-L-arginine degradation" EXACT [GOC:obol] is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process is_a: GO:2001298 ! N(omega),N(omega)-dimethyl-L-arginine metabolic process created_by: pr creation_date: 2012-02-14T03:40:03Z [Term] id: GO:2001300 name: lipoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [CHEBI:6497, GOC:mw] synonym: "lipoxin metabolism" EXACT [GOC:obol] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process created_by: rfoulger creation_date: 2012-03-07T11:11:08Z [Term] id: GO:2001301 name: lipoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [CHEBI:6497, GOC:mw] synonym: "lipoxin anabolism" EXACT [GOC:obol] synonym: "lipoxin biosynthesis" EXACT [GOC:obol] synonym: "lipoxin formation" EXACT [GOC:obol] synonym: "lipoxin synthesis" EXACT [GOC:obol] is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process is_a: GO:0046456 ! icosanoid biosynthetic process is_a: GO:2001300 ! lipoxin metabolic process created_by: rfoulger creation_date: 2012-03-07T11:11:13Z [Term] id: GO:2001302 name: lipoxin A4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [CHEBI:6498, GOC:mw] synonym: "lipoxin A4 metabolism" EXACT [GOC:obol] synonym: "LXA4 metabolic process" EXACT [GOC:obol] synonym: "LXA4 metabolism" EXACT [GOC:obol] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process is_a: GO:2001300 ! lipoxin metabolic process created_by: rfoulger creation_date: 2012-03-07T11:13:12Z [Term] id: GO:2001303 name: lipoxin A4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [CHEBI:6498, GOC:mw] synonym: "lipoxin A4 anabolism" EXACT [GOC:obol] synonym: "lipoxin A4 biosynthesis" EXACT [GOC:obol] synonym: "lipoxin A4 formation" EXACT [GOC:obol] synonym: "lipoxin A4 synthesis" EXACT [GOC:obol] synonym: "LXA4 anabolism" EXACT [GOC:obol] synonym: "LXA4 biosynthesis" EXACT [GOC:obol] synonym: "LXA4 biosynthetic process" EXACT [GOC:obol] synonym: "LXA4 formation" EXACT [GOC:obol] synonym: "LXA4 synthesis" EXACT [GOC:obol] is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:2001301 ! lipoxin biosynthetic process is_a: GO:2001302 ! lipoxin A4 metabolic process created_by: rfoulger creation_date: 2012-03-07T11:13:18Z [Term] id: GO:2001304 name: lipoxin B4 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [CHEBI:6499, GOC:mw] synonym: "lipoxin B4 metabolism" EXACT [GOC:obol] synonym: "LXB4 metabolic process" EXACT [GOC:obol] synonym: "LXB4 metabolism" EXACT [GOC:obol] is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process is_a: GO:2001300 ! lipoxin metabolic process created_by: rfoulger creation_date: 2012-03-07T11:14:58Z [Term] id: GO:2001305 name: xanthone-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xanthone-containing compound." [CHEBI:51149, GOC:di] synonym: "xanthone metabolism" NARROW [CHEBI:37647] synonym: "xanthone-containing compound metabolism" EXACT [GOC:obol] synonym: "xanthones metabolic process" EXACT [GOC:obol] synonym: "xanthones metabolism" EXACT [GOC:obol] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: rfoulger creation_date: 2012-03-14T10:35:38Z [Term] id: GO:2001306 name: lipoxin B4 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [CHEBI:6499, GOC:mw] synonym: "lipoxin B4 anabolism" EXACT [GOC:obol] synonym: "lipoxin B4 biosynthesis" EXACT [GOC:obol] synonym: "lipoxin B4 formation" EXACT [GOC:obol] synonym: "lipoxin B4 synthesis" EXACT [GOC:obol] synonym: "LXB4 anabolism" EXACT [GOC:obol] synonym: "LXB4 biosynthesis" EXACT [GOC:obol] synonym: "LXB4 biosynthetic process" EXACT [GOC:obol] synonym: "LXB4 formation" EXACT [GOC:obol] synonym: "LXB4 synthesis" EXACT [GOC:obol] is_a: GO:0042759 ! long-chain fatty acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:2001301 ! lipoxin biosynthetic process is_a: GO:2001304 ! lipoxin B4 metabolic process created_by: rfoulger creation_date: 2012-03-07T11:15:04Z [Term] id: GO:2001307 name: xanthone-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a xanthone-containing compound." [CHEBI:51149, GOC:di] synonym: "xanthone biosynthesis" NARROW [CHEBI:37647] synonym: "xanthone biosynthetic process" NARROW [CHEBI:37647] synonym: "xanthone-containing compound anabolism" EXACT [GOC:obol] synonym: "xanthone-containing compound biosynthesis" EXACT [GOC:obol] synonym: "xanthone-containing compound formation" EXACT [GOC:obol] synonym: "xanthone-containing compound synthesis" EXACT [GOC:obol] synonym: "xanthones anabolism" EXACT [GOC:obol] synonym: "xanthones biosynthesis" EXACT [GOC:obol] synonym: "xanthones biosynthetic process" EXACT [GOC:obol] synonym: "xanthones formation" EXACT [GOC:obol] synonym: "xanthones synthesis" EXACT [GOC:obol] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:2001305 ! xanthone-containing compound metabolic process created_by: rfoulger creation_date: 2012-03-14T10:35:44Z [Term] id: GO:2001308 name: gliotoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [CHEBI:299453, CHEBI:5385, GOC:di, PMID:16333108, PMID:17574915, PMID:18272357] synonym: "gliotoxin metabolism" EXACT [GOC:obol] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: pr creation_date: 2012-03-15T03:42:10Z [Term] id: GO:2001309 name: gliotoxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357] synonym: "gliotoxin breakdown" EXACT [GOC:obol] synonym: "gliotoxin catabolism" EXACT [GOC:obol] synonym: "gliotoxin degradation" EXACT [GOC:obol] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:2001308 ! gliotoxin metabolic process created_by: pr creation_date: 2012-03-15T03:42:14Z [Term] id: GO:2001310 name: gliotoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357, PMID:29966253] synonym: "gliotoxin anabolism" EXACT [GOC:obol] synonym: "gliotoxin biosynthesis" EXACT [GOC:obol] synonym: "gliotoxin formation" EXACT [GOC:obol] synonym: "gliotoxin synthesis" EXACT [GOC:obol] is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process is_a: GO:2001308 ! gliotoxin metabolic process relationship: has_part GO:0003839 ! gamma-glutamylcyclotransferase activity relationship: has_part GO:0004364 ! glutathione transferase activity relationship: has_part GO:0004497 ! monooxygenase activity relationship: has_part GO:0008170 ! N-methyltransferase activity relationship: has_part GO:0008483 ! transaminase activity created_by: pr creation_date: 2012-03-15T03:42:18Z [Term] id: GO:2001311 name: lysobisphosphatidic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate metabolic process" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate metabolism" EXACT [GOC:obol] synonym: "LBPA metabolic process" EXACT [GOC:obol] synonym: "LBPA metabolism" EXACT [GOC:obol] synonym: "lysobisphosphatidic acid metabolism" EXACT [GOC:obol] is_a: GO:0006650 ! glycerophospholipid metabolic process is_a: GO:0052646 ! alditol phosphate metabolic process created_by: rfoulger creation_date: 2012-03-16T09:31:27Z [Term] id: GO:2001312 name: lysobisphosphatidic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) formation" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate anabolism" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthesis" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthetic process" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate formation" EXACT [GOC:obol] synonym: "bis(monoacylglycerol) hydrogen phosphate synthesis" EXACT [GOC:obol] synonym: "LBPA anabolism" EXACT [GOC:obol] synonym: "LBPA biosynthesis" EXACT [GOC:obol] synonym: "LBPA biosynthetic process" EXACT [GOC:obol] synonym: "LBPA formation" EXACT [GOC:obol] synonym: "LBPA synthesis" EXACT [GOC:obol] synonym: "lysobisphosphatidic acid anabolism" EXACT [GOC:obol] synonym: "lysobisphosphatidic acid biosynthesis" EXACT [GOC:obol] synonym: "lysobisphosphatidic acid formation" EXACT [GOC:obol] synonym: "lysobisphosphatidic acid synthesis" EXACT [GOC:obol] is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:2001311 ! lysobisphosphatidic acid metabolic process created_by: rfoulger creation_date: 2012-03-16T09:31:31Z [Term] id: GO:2001313 name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism" EXACT [GOC:obol] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process created_by: pr creation_date: 2012-03-22T01:19:54Z [Term] id: GO:2001314 name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown" EXACT [GOC:obol] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism" EXACT [GOC:obol] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation" EXACT [GOC:obol] is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process created_by: pr creation_date: 2012-03-22T01:20:01Z [Term] id: GO:2001315 name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf, UniPathway:UPA00032] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism" EXACT [GOC:obol] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis" EXACT [GOC:obol] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation" EXACT [GOC:obol] synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis" EXACT [GOC:obol] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process created_by: pr creation_date: 2012-03-22T01:20:05Z [Term] id: GO:2001316 name: kojic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving kojic acid." [GOC:di] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process" EXACT [GOC:obol] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism" EXACT [GOC:obol] synonym: "C6H6O4 metabolic process" RELATED [GOC:obol] synonym: "C6H6O4 metabolism" RELATED [GOC:obol] synonym: "kojic acid metabolism" EXACT [GOC:obol] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: rfoulger creation_date: 2012-04-18T09:22:42Z [Term] id: GO:2001317 name: kojic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of kojic acid." [GOC:di] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:obol] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:obol] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:obol] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:obol] synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:obol] synonym: "C6H6O4 anabolism" RELATED [GOC:obol] synonym: "C6H6O4 biosynthesis" RELATED [GOC:obol] synonym: "C6H6O4 biosynthetic process" RELATED [GOC:obol] synonym: "C6H6O4 formation" RELATED [GOC:obol] synonym: "C6H6O4 synthesis" RELATED [GOC:obol] synonym: "kojic acid anabolism" EXACT [GOC:obol] synonym: "kojic acid biosynthesis" EXACT [GOC:obol] synonym: "kojic acid formation" EXACT [GOC:obol] synonym: "kojic acid synthesis" EXACT [GOC:obol] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:2001316 ! kojic acid metabolic process created_by: rfoulger creation_date: 2012-04-18T09:22:46Z [Typedef] id: ends_during name: ends_during namespace: external xref: RO:0002093 [Typedef] id: happens_during name: happens during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_part name: has part namespace: external xref: BFO:0000051 is_transitive: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 is_a: regulates ! regulates [Typedef] id: never_in_taxon name: never_in_taxon namespace: external xref: RO:0002161 expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" [] is_metadata_tag: true is_class_level: true [Typedef] id: occurs_in name: occurs in namespace: external xref: BFO:0000066 transitive_over: part_of ! part of [Typedef] id: part_of name: part of namespace: external xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has part [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 holds_over_chain: negatively_regulates negatively_regulates is_a: regulates ! regulates [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 is_transitive: true [Typedef] id: starts_during name: starts_during namespace: external xref: RO:0002091